tbuckley/cabot-search huggingface dataset:
The trouble with TRIBbles: TRIB3 blocks CD8 T cell homing to colorectal cancers
Authors: Rachael A. Clark
Journal: Science Immunology (2022)

Colon cancer–derived TRIB3 reduced CXCL10 transcription and impaired CD8 T cell homing into tumors; reduction of TRIB3 levels increased CD8 T cell infiltration and rendered tumors responsive to immune checkpoint blockade.
Evolution of Amino Acid Propensities under Stability-Mediated Epistasis
Authors: Noor Youssef, Edward Susko, Andrew J Roger, Joseph P Bielawski
Journal: Molecular Biology and Evolution (2022)

Abstract Site-specific amino acid preferences are influenced by the genetic background of the protein. The preferences for resident amino acids are expected to, on average, increase over time because of replacements at other sites—a nonadaptive phenomenon referred to as the “evolutionary Stokes shift.” Alternatively, decreases in resident amino acid propensity have recently been viewed as evidence of adaptations to external environmental changes. Using population genetics theory and thermodynamic stability constraints, we show that nonadaptive evolution can lead to both positive and negative shifts in propensities following the fixation of an amino acid, emphasizing that the detection of negative shifts is not conclusive evidence of adaptation. By examining propensity shifts from when an amino acid is first accepted at a site until it is subsequently replaced, we find that ≈50% of sites show a decrease in the propensity for the newly resident amino acid while the remaining sites show an increase. Furthermore, the distributions of the magnitudes of positive and negative shifts were comparable. Preferences were often conserved via a significant negative autocorrelation in propensity changes—increases in propensities often followed by decreases, and vice versa. Lastly, we explore the underlying mechanisms that lead propensities to fluctuate. We observe that stabilizing replacements increase the mutational tolerance at a site and in doing so decrease the propensity for the resident amino acid. In contrast, destabilizing substitutions result in more rugged fitness landscapes that tend to favor the resident amino acid. In summary, our results characterize propensity trajectories under nonadaptive stability-constrained evolution against which evidence of adaptations should be calibrated.
Effect of Fasting on Fibrinolysis and Blood Coagulation
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TCT-624 The Utility of Saline-Induced Resting Full-Cycle Ratio Compared With Resting Full-Cycle Ratio and Fractional Flow Reserve
Authors: Takao Sato, Sonoka Goto, Yusuke Ohta, Yuji Taya, Sho Yuasa, Minoru Takahashi, Masaaki Okabe, Yoshifusa Aizawa
Journal: Journal of the American College of Cardiology (2019)
Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial
Authors: Stefan Hagel, Friedhelm Bach, Thorsten Brenner, Hendrik Bracht, Alexander Brinkmann, Thorsten Annecke, Andreas Hohn, Markus Weigand, Guido Michels, Stefan Kluge, Axel Nierhaus, Dominik Jarczak, Christina König, Dirk Weismann, Otto Frey, Dominic Witzke, Carsten Müller, Michael Bauer, Michael Kiehntopf, Sophie Neugebauer, Thomas Lehmann, Jason A. Roberts, Mathias W. Pletz, Anke Braune, Karsten Schmidt, Johann Motsch, Nadine Pinder, Daniel Richter, Peter Schlattmann, Andreas Ameln-Mayerhofer von, Markus Schappacher, Thomas Fuchs, Anka Röhr, Max Kurlbaum, Oliver Schreiner, Lars Hüter, Matthias Gründling, Stefan Angermair, Maria Deja, Frank Bloos, Sandra Fiedler, Hicham Chkirni
Journal: Intensive Care Medicine (2022)

Insufficient antimicrobial exposure is associated with worse outcomes in sepsis. We evaluated whether therapeutic drug monitoring (TDM)-guided antibiotic therapy improves outcomes. Randomized, multicenter, controlled trial from January 2017 to December 2019. Adult patients (n = 254) with sepsis or septic shock were randomly assigned 1:1 to receive continuous infusion of piperacillin/tazobactam with dosing guided by daily TDM of piperacillin or continuous infusion with a fixed dose (13.5 g/24 h if eGFR ≥ 20 mL/min). Target plasma concentration was four times the minimal inhibitory concentration (range ± 20%) of the underlying pathogen, respectively, of Pseudomonas aeruginosa in empiric situation. Primary outcome was the mean of daily total Sequential Organ Failure Assessment (SOFA) score up to day 10. Among 249 evaluable patients (66.3 ± 13.7 years; female, 30.9%), there was no significant difference in mean SOFA score between patients with TDM (7.9 points; 95% CI 7.1–8.7) and without TDM (8.2 points; 95% CI 7.5–9.0) (p = 0.39). Patients with TDM-guided therapy showed a lower 28-day mortality (21.6% vs. 25.8%, RR 0.8, 95% CI 0.5–1.3, p = 0.44) and a higher rate of clinical (OR 1.9; 95% CI 0.5–6.2, p = 0.30) and microbiological cure (OR 2.4; 95% CI 0.7–7.4, p = 0.12), but these differences did not reach statistical significance. Attainment of target concentration was more common in patients with TDM (37.3% vs. 14.6%, OR 4.5, CI 95%, 2.9–6.9, p < 0.001). TDM-guided therapy showed no beneficial effect in patients with sepsis and continuous infusion of piperacillin/tazobactam with regard to the mean SOFA score. Larger studies with strategies to ensure optimization of antimicrobial exposure are needed to definitively answer the question.
Folliculotropic Mycosis Fungoides
Authors: An-kang Gu, Jing Shi, Yu Zhang
Journal: JAMA Dermatology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Impact of lanadelumab on patient-reported outcomes in hereditary angioedema in the US and Canada: Interim findings from the EMPOWER Study
Authors: Paula Busse, Rafael Zaragoza-Urdaz, Stephen Betschel, H. James Wedner, Emily Brouwer, Tomas Andriotti, Kezhen Fei, Michael Manning, Bruce Zuraw, Jonathan Bernstein
Journal: Journal of Allergy and Clinical Immunology (2022)
"ENCYCLOPAEDIA MEDICA."
Authors: C. E. Green
Journal: BMJ (1914)

battlefield than anywhere.The admirable state- ment of the case uttered by Lord Roberts in addressing the new 10th Battalion of the Royal' Fusiliers on August 29th, reminding the athlete that it is no time for games, that hundreds of thousands of men are wanted, but that only a minimum number can be officers, requires to be more widely read and appreciated.At the same time information as to centres of service for warfare and home defence will be found in the newspapers, or may be sought by unlucky veterans, to whom the door has been closed, ,at the headquarters of such bodies as the Honourable Artillery Company, the Corps of Veterans (ex-service men), and the Inns of Court Veteran Corps.
A piece of my mind. So much more to say
Authors: P. T. Leff
Journal: JAMA (1989)

"That woman—she never leaves me alone," I mutter to my friend as we dash to the cafeteria. "Every lab value. Every pulmonary treatment. Every IV. Every insulin injection. Every bowel movement...." My buddy nods knowingly. All of the interns have served time with Mrs Davis, Christy's mother. As we whizz past the clock, I turn my head for a second. Mrs Davis is flying after me and quickly gaining ground. I shiver: Patty, won't you ever learn to muzzle your mouth? "That woman" has probably heard a good 90% of the nasty things you've said about her. "Dr Leff, I thought we were going to see the radiologist together," she attacks. "Mrs Davis, we will. Let me grab lunch first; you could take a break too. Then we'll go straight to radiology. There really is no hurry," I plead, I implore; I'm hungry, I'm exhausted. She senses the earnestness in
Evolutionary Landscapes of Host-Virus Arms Races
Authors: Jeannette L. Tenthorey, Michael Emerman, Harmit S. Malik
Journal: Annual Review of Immunology (2022)

Vertebrate immune systems suppress viral infection using both innate restriction factors and adaptive immunity. Viruses mutate to escape these defenses, driving hosts to counterevolve to regain fitness. This cycle recurs repeatedly, resulting in an evolutionary arms race whose outcome depends on the pace and likelihood of adaptation by host and viral genes. Although viruses evolve faster than their vertebrate hosts, their proteins are subject to numerous functional constraints that impact the probability of adaptation. These constraints are globally defined by evolutionary landscapes, which describe the fitness and adaptive potential of all possible mutations. We review deep mutational scanning experiments mapping the evolutionary landscapes of both host and viral proteins engaged in arms races. For restriction factors and some broadly neutralizing antibodies, landscapes favor the host, which may help to level the evolutionary playing field against rapidly evolving viruses. We discuss the biophysical underpinnings of these landscapes and their therapeutic implications.
State Boards of Registration.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Successful treatment of an iatrogenic biliary stricture using holmium laser “recanalization” and multistenting technique
Authors: Roberto Di Mitri, Daniela Scimeca, Michele Amata, Filippo Mocciaro, Ambra Bonaccorso, Elisabetta Conte, Mario Vallone
Journal: Endoscopy (2022)

A 55-year-old woman admitted for jaundice 2 months after cholecystectomy underwent magnetic resonance imaging, which showed a common bile duct (CBD) stricture. Cholangiography during endoscopic retrograde cholangiopancreatography ([Fig. 1]) confirmed a tight stricture of the proximal CBD and lack of visualization of the intrahepatic bile ducts (IHBD). At cholangioscopy using SpyGlass DS (Boston Scientific), a complete stricture of the proximal CBD was observed with a metallic clip visible inside the CBD ([Fig. 2]). The on-call interventional radiologist performed a percutaneous transhepatic biliary drainage (PTBD) procedure in order to try a rendezvous approach. Percutaneous contrast medium injection confirmed dilated IHBD with complete absence of the proximal CBD lumen for a length of at least 5 mm. Multiple attempts to pass a guidewire through the stricture, both percutaneously and endoscopically, failed.
LONDON
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CANADA'S HUNDRED YEARS
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Persistence of protection against SARS-CoV-2 clinical outcomes up to 9 months since vaccine completion: a retrospective observational analysis in Lombardy, Italy
Authors: Giovanni Corrao, Matteo Franchi, Danilo Cereda, Francesco Bortolan, Alberto Zoli, Olivia Leoni, Catia Rosanna Borriello, Giulia Petra Della Valle, Marcello Tirani, Giovanni Pavesi, Antonio Barone, Michele Ercolanoni, Jose Jara, Massimo Galli, Guido Bertolaso, Giuseppe Mancia
Journal: The Lancet Infectious Diseases (2022)
Effectiveness of mepolizumab, benralizumab, and dupilumab in eosinophilic asthma: A Bayesian network meta-analysis
Authors: Ayobami Akenroye, Grace Lassiter, John Jackson, Corinne Keet, Jodi Segal, Caleb Alexander, Hwanhee Hong
Journal: Journal of Allergy and Clinical Immunology (2022)
Validation of the Danish version of the Quality of Life in Hand Eczema Questionnaire ( <scp>QOLHEQ</scp> )
Authors: Yasemin Topal Yüksel, Kristina Ibler, Tove Agner, Robert Ofenloch
Journal: British Journal of Dermatology (2022)

Dear Editor, Health‐related quality of life (HRQOL) measurements are important patient‐reported outcomes when evaluating treatment responses and the effect of interventions in patients with hand eczema (HE). In recent years, the disease‐specific Quality of Life in Hand Eczema Questionnaire (QOLHEQ) has been increasingly used and validated in different languages.1–3 However, a Danish validation is missing. Thus, our objective was to assess the validity of single scores and the internal consistency of the Danish version of the QOLHEQ. We translated the English version of the QOLHEQ into Danish by forward and backward translations in accordance with previously published guidelines.4 The QOLHEQ comprises 30 items grouped in four domains: symptoms, emotions, functioning, and treatment and prevention. The total score has a range from 0 to 127, with higher scores indicating higher impairment in HRQOL. In this cross‐sectional study, patients with HE were recruited from the dermatological outpatient clinic at Bispebjerg Hospital between March and December 2018, and between August and December 2019. They were asked to complete the QOLHEQ and reference instruments. The reference instruments were the EuroQol 5 Dimensions 3 Levels (EQ‐5D‐3L), which is a generic HRQOL questionnaire with five domains (mobility, self‐care, usual activities, pain/discomfort, anxiety/depression) and EQ‐VAS, which is a visual analogue scale (VAS) for self‐rated health ranging from 0 to 100, with 100 indicating 'best imaginable health state'. In addition to the patient‐administered questionnaires, a trained physician assessed the patients' HE severity with the Physician Global Assessment (PGA) using a photographic guide,5 and the Hand Eczema Severity Index (HECSI).6 The study was approved by the local ethics committee and data protection agency. Informed consent was obtained from all patients.
Confronting Health Care’s Climate Crisis Conundrum
Authors: Kenneth W. Kizer, Kari Christine Nadeau
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies
Authors: Jason H Y Wu, Matti Marklund, Fumiaki Imamura, Nathan Tintle, Andres V Ardisson Korat, Janette de Goede, Xia Zhou, Wei-Sin Yang, Marcia C de Oliveira Otto, Janine Kröger, Waqas Qureshi, Jyrki K Virtanen, Julie K Bassett, Alexis C Frazier-Wood, Maria Lankinen, Rachel A Murphy, Kalina Rajaobelina, Liana C Del Gobbo, Nita G Forouhi, Robert Luben, Kay-Tee Khaw, Nick Wareham, Anya Kalsbeek, Jenna Veenstra, Juhua Luo, Frank B Hu, Hung-Ju Lin, David S Siscovick, Heiner Boeing, Tzu-An Chen, Brian Steffen, Lyn M Steffen, Allison Hodge, Gudny Eriksdottir, Albert V Smith, Vilmunder Gudnason, Tamara B Harris, Ingeborg A Brouwer, Claudine Berr, Catherine Helmer, Cecilia Samieri, Markku Laakso, Michael Y Tsai, Graham G Giles, Tarja Nurmi, Lynne Wagenknecht, Matthias B Schulze, Rozenn N Lemaitre, Kuo-Liong Chien, Sabita S Soedamah-Muthu, Johanna M Geleijnse, Qi Sun, William S Harris, Lars Lind, Johan Ärnlöv, Ulf Riserus, Renata Micha, Dariush Mozaffarian
Journal: The Lancet Diabetes & Endocrinology (2017)
A Mutation in the Thyroid Hormone Receptor Alpha Gene
Authors: Elena Bochukova, Nadia Schoenmakers, Maura Agostini, Erik Schoenmakers, Odelia Rajanayagam, Julia M. Keogh, Elana Henning, Jana Reinemund, Evelien Gevers, Margarita Sarri, Kate Downes, Amaka Offiah, Assunta Albanese, David Halsall, John W.R. Schwabe, Murray Bain, Keith Lindley, Francesco Muntoni, Faraneh Vargha-Khadem, Mehul Dattani, I. Sadaf Farooqi, Mark Gurnell, Krishna Chatterjee
Journal: New England Journal of Medicine (2011)

Thyroid hormones exert their effects through alpha (TRα1) and beta (TRβ1 and TRβ2) receptors. Here we describe a child with classic features of hypothyroidism (growth retardation, developmental retardation, skeletal dysplasia, and severe constipation) but only borderline-abnormal thyroid hormone levels. Using whole-exome sequencing, we identified a de novo heterozygous nonsense mutation in a gene encoding thyroid hormone receptor alpha (THRA) and generating a mutant protein that inhibits wild-type receptor action in a dominant negative manner. Our observations are consistent with defective human TRα-mediated thyroid hormone resistance and substantiate the concept of hormone action through distinct receptor subtypes in different target tissues.