tbuckley/cabot-search huggingface dataset:
OP0117 The effect of anakinra in slowing radiologic progression in rheumatoid arthritis patients ? evidence from a bootstrap analysis
Authors: MW Cravets, E Ng, MB Bear
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> Anakinra was studied in a randomised placebo-controlled study of 473 patients with rheumatoid arthritis (RA). Patients were randomised to one of 4 treatment groups (placebo, 30 mg, 75 mg or 150 mg anakinra) and treated for 24 weeks. Radiographic assessments of the hands and wrists based on Larsen score (Larsen 1977) were collected at baseline and 24 weeks. At the end of the study, about 27% of the patients withdrew. To assess the anakinra effect on reducing joint damage, the potential influence of dropouts on the study conclusions must be taken into account. <h3>Objectives</h3> To demonstrate that the effect of anakinra in reducing the rate of radiologic disease progression is robust and insensitive to potential biases due to losses of followup. <h3>Methods</h3> The 3 anakinra dose groups were combined into a single treatment group which was then compared to placebo. For each treatment group, x% of the missing Larsen score changes from baseline to week 24 were imputed by randomly selecting the observed change scores from the same treatment group, and the rest of the missing data were imputed similarly from the opposite treatment group. The resampled (bootstrapped) data were then analysed by an ANOVA model. This resampling procedure was repeated 1000 times, resulting in the estimation of 1000 p-values for testing the treatment effect. These 1000 p-values were then summarised to give an estimated picture of the IL-1ra treatment effect. By changing the proportion of sampling (x) systematically, the effect of anakinra on radiologic progression can be studied under different scenarios of missing data. <h3>Results</h3> The results from all the analyses indicated that there was improvement in radiologic progression with anakinra treatment for 24 weeks. Statistical significance was maintained when up to 40% of the missing data were sampled from the opposite treatment group (mean and median p-values range from 0.021 to 0.078, and 0.011 to 0.05 respectively). <h3>Conclusion</h3> Anakinra has a statistically significant effect on slowing the progression of disease for 24 weeks of treatment as measured by the Larsen Score, even when as much as 40% of the missing anakinra scores are imputed with placebo values.
AB0024 ASSOCIATION OF IL6 RS1800795 BUT NOT IL6R RS2228145, RS4845618 AND STAT4 RS7574865 POLYMORPHISMS WITH CHLAMYDIA-ASSOCIATED RHEUMATOID ARTHRITIS
Authors: T. Zybalova, V. Yagur, R. Goncharova, N. Soroka, N. Dostanko, V. Apanasovich, A. Tushina
Journal: Annals of the Rheumatic Diseases (2020)

Background: Rheumatoid arthritis (RA), associated with Chlamydial Infection, has some clinical and immunological particulars that interfere with the early diagnosis and require significant changes in treatment strategy [1]. Objectives: To estimate the distribution of some non-HLA genetic markers such as STAT4 rs7574865, IL6 rs1800795, IL6R rs2228145 and rs4845618 in Chlamydia positive and negative RA patients and healthy controls. Methods: We examined 380 healthy blood donors and 187 RA patients classified according to the ACR/EULAR 2010 criteria for RA [2]. Twenty-three of the RA patients were positive for Chlamidia trachomatis (n=17) or Chlamidia pneumonia (n=6) persistence. DNA from peripheral blood samples was extracted by phenol-chloroform method. SNPs were genotyped by the real-time PCR with fluorescent probes. Statistical significance of SNPs’ frequency was estimated by two-way Fisher exact test (F, p 2-t ) with Bonferroni correction for multiple comparisons (p cor ). Moreover, diagnostic odds ratio (dOR), the likelihood ratio of positive (LR + ) and negative (LR – ) tests and corresponding confidence intervals (CI) were calculated. Results: We revealed statistically significant increase of genotype СС frequency (IL6 rs1800795) in Chlamydia-associated RA (60.9%) vs healthy donors (20.7%): p 2-t =0.000065; p cor =0.00026; dOR=5.95 (CI 95% 2.53-13.94); LR + =2.94 (CI 95% 1.90-3.29); LR – =0.49 (CI 95% 0.28-0.75) as well as in Chlamydia-associated RA (60.9%) vs Chlamydia-negative RA (23.9%): p 2-t =0.00051; p cor =0.002; dOR=4.99 (CI 95% 2.04-12.16); LR + =2.56 (CI 95% 1.60-3.57); LR – =0.51 (CI 95% 0.29-0.78). Significant differences in STAT4 rs7574865, IL6R rs2228145 and IL6R rs4845618 distribution between studied groups were not found. Conclusion: Our data suggest the association between СС genotype of IL6 rs1800795 and Chlamydia-associated RA. References: [1]Soroka N.F. Rheumatoid Arthritis, associated with Chlamydial infection // Healthcare 2009; 1: 5-9. [2]Aletaha D. et al. 2010 Rheumatoid arthritis classification criteria// Arthritis Rheum 2010; 62 (9): 2569-81. Disclosure of Interests: Tatiana Zybalova: None declared, Viktor Yagur: None declared, Roza Goncharova: None declared, Nikolaj Soroka Grant/research support from: JSC BIOCAD, Natalia Dostanko: None declared, Valery Apanasovich: None declared, Anastasiya Tushina: None declared
Reproductive desires in transgender and gender diverse adults: A cross-sectional study in Thailand
Authors: Natnita Mattawanon, Unyamanee Kummaraka, Awirut Oon-arom, Natthaporn Manojai, Vin Tangpricha
Journal: International Journal of Transgender Health (2021)

Objective: To explore the desires and barriers to fertility preservation among transgender women and gender diverse people assigned male at birth in Thailand. Material and methods: This study is a cross-sectional study in clinic-based setting. The data was obtained from a questionnaire. Three hundred and three participants visiting the Gender Care Clinic at Chiang Mai University Hospital and Mplus clinics between April 2019 and December 2019 were included. Of these, 199 were transgender women and 104 were gender diverse people assigned male at birth. Results: The overall parental desire was 30.4% which was similar across the 2 groups (p = 0.897). A genetically related child was preferred in 40.9% of transgender women and 50.5% of gender diverse group (p = 0.115). Factors impacting a parental desire were a good relationship with family (OR 2.905, 95%CI 1.315-6.420, p = 0.008), being in a stable relationship (OR 4.183, 95%CI 1.738-10.069, p < 0.001) and belief in a positive attitude of society toward LGBTQ parenting (OR 2.572, 95%CI 1.207-5.479, p = 0.014). Access to fertility preservation services was low. The majority of transgender women (75.3%) and gender diverse people (95.2%) never received a consultation regarding fertility. The utilization rate of fertility treatments was 5.3% in our study. Conclusion: Transgender women and gender diverse people assigned male at birth have parental desires for a genetically related child. However, access to reproductive information, consultation and services were very limited. Social support along with competent health services might increase access to reproductive services in transgender and gender diverse populations.
Abstract 18606: The Value of Cardiac Magnetic Resonance Imaging in Detection of Sub-Clinical Cellular Rejection
Authors: Markus J Barten, Jens Garbade, Hartmuth B Bittner, Friedrich W Mohr, Matthias M Gutberlet
Journal: Circulation (2013)

Background: Sub-clinical acute cellular rejection (ACR) after heart transplantation (HTx) is a major cause of cardiac allograft vasculopathy. But with endomyocardial biopsy (EMB) the detection of sub-clinical ACR is limited by sampling error, interobserver variability or the wide variability of frequency and duration to use this invasive interventional tool. Thus, we used cardiac magnetic resonance imaging (CMRI) to identify sub-clinical ACR after HTx. Methods: In total 73 patients with a mean age of 53±12 years were scanned 167 times with a 1.5T-MRI scanner using a standard myocarditis protocol to detect sub-clinical ACR. Myocardial edema and myocyte damage were determined by using specific “cut-off” values to determine inflammatory parameters of early- and delayed- enhancement as well as to determine water content. CMRI-results were correlated with results of EMB performed on the same day using the original ISHLT EMB guidelines to more accurately determine sub-clinical ACR. Results: In 87 (52%) out of 167 biopsies a rejection grade of 1A was diagnosed, whereas 16 biopsies (10%) were graded 1B, 2 biopsies (1.1%) 2A and 1 biopsy (0.5%) 3A, respectively. No rejection was diagnosed in 61 biopsies (36%). Sensitivity, specificity and negative predictive value for rejection grade ≥1B were for (1) early-enhancement 64%, 70% and 93%; (2) delayed-enhancement 43%, 38% and 82%; (3) water content: 60%, 79% and 93%. In combination of all 3 parameters sensitivity, specificity and negative predictive value were: 71%, 66% and 94%. Conclusion: We showed that a combination of specific CMRI parameters have a high negative predictive value in early detection of sub-clinical ACR. Future clinical studies need further to evaluate CMR as an evolving tool in ACR.
Preordering School Lunch Encourages Better Food Choices by Children
Authors: Andrew S. Hanks, David R. Just, Brian Wansink
Journal: JAMA Pediatrics (2013)

Andrew S. Hanks is a Post-Doctoral Research Associate in the Department of Applied Economics and Management at Cornell University. Dr. Hanks is Corresponding Author. Address: 17 Warren Hall, Cornell University Ithaca, NY 14853. E-mail: ah748@cornell.edu. Phone: 607-339-6942. Fax: 607-255-9984. David R. Just is Associate Professor of Behavioral Economics in the Department of Applied Economics and Management at Cornell University. Brian Wansink is the John S. Dyson Professor of Marketing in the Department of Applied Economics and Management at Cornell University.
False-Positive Uptake of 131I From Basal Cell Papilloma in a Patient With Metastatic Papillary Thyroid Cancer
Authors: Lingling Luo, Jiaqiong Wang, Junyong Xia, Ran Zhang, Xiaobo Yao
Journal: Clinical Nuclear Medicine (2021)

Abstract A 64-year-old woman with metastatic papillary thyroid cancer underwent a total thyroidectomy followed by 2 courses of 131 I therapy. The posttherapeutic whole-body scan after the second dose of 131 I therapy showed multifocal bone metastasis. In addition, there is focal abnormal intense radiotracer uptake at the right inguinal region. SPECT/CT revealed that this abnormal focal radioactivity was from a superficial skin lesion. Further physical examination revealed a raised, approximately 1-cm, irregular grayish-brown lesion on the right groin skin. Histopathological examination confirmed the diagnosis of basal cell papilloma (seborrheic keratosis).
External Cardiac Loop Recorders: Functionalities, Diagnostic Efficacy, Challenges and Opportunities
Authors: Rama Reddy Rajanna, Natarajan Sriraam, V. S. Prakash, Prabhu Ravikala Vittala, Uma Arun, Sarthak Sahoo
Journal: IEEE Reviews in Biomedical Engineering (2021)

According to the World Health Organization's (WHO) report of 2016, cardiovascular diseases (CVDs) accounted for mortality of an estimated 17.9 million people globally. Of these deaths, 85% were due to myocardial infarction and stroke. Further, the pre-dominant atrial fibrillation (AF) arrhythmia has been the most suspected underlying cause of transient ischemic attack or stroke. Thus, the etiologies of early symptoms like syncope and palpitations in patients needs to be evaluated by employing proper diagnostic tests to make early treatment decisions. The most widely referred 24 to 48 hour Holter electrocardiographic (ECG) monitoring tests have not been proved to be much effective in recognizing infrequent intermittent arrhythmic episodes. These drawbacks have led to the development of long-term ambulatory ECG (AECG) monitoring devices. This review reports the state-of-the-art existing AECG monitoring devices and their role of long-term ECG recording in patients suspected with cardiac syncope and palpitations to understand the underlying arrhythmic cause, as well as in the diagnosis and management of AF. Primarily, the utility and diagnostic yield of external cardiac recorders or event loop recorders (ELRs) in capturing the symptom-rhythm correlation which constitutes a clinically useful recordings of heart's electrical activity during infrequent arrhythmic conditions was critically reviewed. Furthermore, a brief case study on challenges involved in clinical data acquisition at a cardiac care unit using ambulatory external monitoring device has been presented. Finally, improvements in design engineering and algorithmic developments to enhance the diagnostic yield and usability of ELRs in clinical settings have been proposed.
OP0046 Histopathologic findings in temporal artery biopsies (tab) examined for vasculitis. results from a high endemic area for temporal arteritis (ta) in southern norway
Authors: G Haugeberg, R Bie, P Quist Paulsen
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> Southern Norway has been shown to have the highest incidence of TA worldwide.<sup>1</sup> Extended histopathological findings from TABs performed in this area have previously not been presented. <h3>Objectives</h3> To examine the frequency and pattern of histopathological findings in TABs performed in patients recruited from a high endemic area for TA. <h3>Methods</h3> All registered TABs in the biopsy database at the Department of Pathology at Vest-Agder Central Hospital (Southern Norway) from the 5-year period 1992–96 were examined. All biopsies were re-examined by one experienced pathologist. All slides were stained with HE stain. In addition, positive biopsies were stained with Giemsa and Lendrum stain. <h3>Results</h3> TABs were performed in 275 patients of which 271 were regarded as representative (180 women and 91 men; mean age 70.9 ± 11.4 yrs). Vasculitis was found in 59 cases (18 men and 41 women; mean age 71.4 ± 8.2 yrs). Arteries with vasculitis had significantly larger diameters than those without inflammation (1.6 ± 0.7 mm vs. 1.2 ± 0.8 mm, P = 0.001), whereas no difference of artery length was found (7.5 ± 3.2 mm vs. 7.6 ± 3.5 mm, P = 0.77). Extension of the inflammation throughout the vessel wall was as follows: transmural 55.2%, media and adventitia 22.4%, adventitia 19.0% and media 3.4%. Reparative fibrosis was found in 52.5%, thrombosis in 3.4% and fibrinoid necrosis in 3.4% of the TABs. The following frequencies of different inflammatory cell types in the TABs were found: giant cells 37.3%, macrophages 45.8%, lymfocytes 100%, plasma cells 37.3%, mast cells 54.3%, neutrophilic granulocytes 88.2% and eosinophilic granulocytes 25.4%. <h3>Conclusion</h3> Histopathologic findings consistent with vasculitis were detected in approx. 1 out of 5 TABs examined in our high endemic area of TA. No difference in biopsy length was found between positive and negative TABs, questioning the importance of recommended large biopsies of 20 mm examining TABs for vasculitis. The types of inflammatory cells were found to be in accordance with previous reports. <h3>Reference</h3> Haugeberg, <i>et al</i>. J Rheumatol. 2000;27:2624–7
THU0007 Association of human mhc class i and class ii genes with susceptibility to systemic lupus erythematosus in malays and chinese
Authors: SS Yeap, KF Kong, YP Tee, SK Chow, ME Phipps
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder. Its prevalence is higher in Chinese and Black populations compared to Caucasians. The prevalence of SLE in Malaysia is estimated to be 43/100,000 population.<sup>1</sup> <h3>Objectives</h3> The objective of this study was to investigate the association between SLE with the human MHC Class I and Class II genes. <h3>Methods</h3> A modified PCR-SSP Methodology, known as Phototyping<sup>2,3</sup> was carried out to determine the HLA-A, -B, -DR and -DQ genes of the subjects. 50 Malays and 50 Chinese patients with SLE fulfilling the ACR criteria were recruited along with 50 Malays and Chinese age- and race-matched controls. <h3>Results</h3> Statistical analysis showed that both the Malay and Chinese have similar results despite minor differences. HLA-A11 is associated with SLE in both races, whereas HLA-DR12 has been found to be statistically significant as protective antigen specificity. Compared to Malays, Chinese SLE patients have a higher frequency of DR2 compared to the controls. DRB1 was only seen in Malay SLE patients (OR 8.69 compared to controls). DRB1*02 and DQB1*05 was only seen in Chinese SLE patients (OR 2.41 compared to controls). Alleles negatively associated with SLE, possibly confering a protective effect are as follows: In both Malay and Chinese SLE patients, DRB1*12, DQB1*0301/4, in Malay SLE patients, DRB1*13, DRB3*0301, in Chinese SLE patients, DRB3*0201. <h3>Conclusion</h3> These results differ from those obtained in other ethnic groups, i.e. suggesting a different disease pathogenesis. <h3>References</h3> Wang F, <i>et al</i>. Lupus 1997;6:248–53 Bunce M, <i>et al</i>. Tissue Antigens 1995;46:355–67 Tee YP, <i>et al</i>. Asia Pacific J Mol Biol Biotech. 1999;7:29–37
Oncolytic virotherapy-mediated anti-tumor response: a single-cell perspective
Authors: Egle Ramelyte, Aizhan Tastanova, Zsolt Balázs, Desislava Ignatova, Patrick Turko, Ulrike Menzel, Emmanuella Guenova, Christian Beisel, Michael Krauthammer, Mitchell Paul Levesque, Reinhard Dummer
Journal: Cancer Cell (2021)
Association of disease characteristics with the temporal sequence of skin and musculoskeletal disease onset in psoriatic arthritis
Authors: K. Tascilar, O. Bayindir, A. Dogru, I. Tinazzi, G. Kimyon, C. Ozisler, A. Erden, E. Dalkilic, G.Y. Cetin, S. Yılmaz, D. Solmaz, S. Bakirci, A. Omma, T. Kasifoglu, O. Kucuksahin, M. Cinar, L. Kilic, M. Can, E.F. Tarhan, E. Bilgin, E.D. Ersozlu, T. Duruoz, S. Yavuz, S. Pehlevan, M.A. Tufan, E. Gonullu, F. Yildiz, S.E. Esmen, A. Kucuk, A. Tufan, A. Balkarli, R. Mercan, V. Yazisiz, S. Erten, S. Akar, K. Aksu, S.Z. Aydin, U. Kalyoncu
Journal: British Journal of Dermatology (2021)

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Renin-angiotensin system blocker and outcomes of COVID-19: a systematic review and meta-analysis
Authors: Hyun Woo Lee, Chang-Hwan Yoon, Eun Jin Jang, Chang-Hoon Lee
Journal: Thorax (2021)

Background The association of ACE inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) with disease severity of patients with COVID-19 is still unclear. We conducted a systematic review and meta-analysis to investigate if ACEI/ARB use is associated with the risk of mortality and severe disease in patients with COVID-19. Methods We searched all available clinical studies that included patients with confirmed COVID-19 who could be classified into an ACEI/ARB group and a non-ACEI/ARB group up until 4 May 2020. A meta-analysis was performed, and primary outcomes were all-cause mortality and severe disease. Results ACEI/ARB use did not increase the risk of all-cause mortality both in meta-analysis for 11 studies with 12 601 patients reporting ORs (OR=0.52 (95% CI=0.37 to 0.72), moderate certainty of evidence) and in 2 studies with 8577 patients presenting HRs. For 12 848 patients in 13 studies, ACEI/ARB use was not related to an increased risk of severe disease in COVID-19 (OR=0.68 (95% CI=0.44 to 1.07); I 2 =95%, low certainty of evidence). Conclusions ACEI/ARB therapy was not associated with increased risk of all-cause mortality or severe manifestations in patients with COVID-19. ACEI/ARB therapy can be continued without concern of drug-related worsening in patients with COVID-19.
Abstract 15715: Induced Pluripotent Stem Cell-derived Cardiomyocytes Uncover High Levels of the Transcriptional Factor STAT3 in Peripartum Cardiomyopathy
Authors: Nili Naftali-Shani, Natali Molotski, Yael Nevo-Caspi, Michael Arad, Rafael Kuperstein, Uri Amit, Irit Huber, Li-At Zeltzer, Haya Abbas, Gidi Paret, Jonathan Leor
Journal: Circulation (2017)

Background and Aim: Peripartum cardiomyopathy (PPCM) is a rare but serious condition of unknown cause. The transcription factor STAT3 regulates a protective and reparative response in the heart. Do...
Heart Disease and Stroke Statistics—2021 Update
Authors: Salim S. Virani, Alvaro Alonso, Hugo J. Aparicio, Emelia J. Benjamin, Marcio S. Bittencourt, Clifton W. Callaway, April P. Carson, Alanna M. Chamberlain, Susan Cheng, Francesca N. Delling, Mitchell S.V. Elkind, Kelly R. Evenson, Jane F. Ferguson, Deepak K. Gupta, Sadiya S. Khan, Brett M. Kissela, Kristen L. Knutson, Chong D. Lee, Tené T. Lewis, Junxiu Liu, Matthew Shane Loop, Pamela L. Lutsey, Jun Ma, Jason Mackey, Seth S. Martin, David B. Matchar, Michael E. Mussolino, Sankar D. Navaneethan, Amanda Marma Perak, Gregory A. Roth, Zainab Samad, Gary M. Satou, Emily B. Schroeder, Svati H. Shah, Christina M. Shay, Andrew Stokes, Lisa B. VanWagner, Nae-Yuh Wang, Connie W. Tsao
Journal: Circulation (2021)

The American Heart Association, in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, and weight) and health factors (cholesterol, blood pressure, and glucose control) that contribute to cardiovascular health. The Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, congenital heart disease, rhythm disorders, subclinical atherosclerosis, coronary heart disease, heart failure, valvular disease, venous disease, and peripheral artery disease) and the associated outcomes (including quality of care, procedures, and economic costs).The American Heart Association, through its Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States to provide the most current information available in the annual Statistical Update. The 2021 Statistical Update is the product of a full year's worth of effort by dedicated volunteer clinicians and scientists, committed government professionals, and American Heart Association staff members. This year's edition includes data on the monitoring and benefits of cardiovascular health in the population, an enhanced focus on social determinants of health, adverse pregnancy outcomes, vascular contributions to brain health, the global burden of cardiovascular disease, and further evidence-based approaches to changing behaviors related to cardiovascular disease.Each of the 27 chapters in the Statistical Update focuses on a different topic related to heart disease and stroke statistics.The Statistical Update represents a critical resource for the lay public, policy makers, media professionals, clinicians, health care administrators, researchers, health advocates, and others seeking the best available data on these factors and conditions.