tbuckley/cabot-search huggingface dataset:
Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies
Authors: Jonathan G Best, Gareth Ambler, Duncan Wilson, Keon-Joo Lee, Jae-Sung Lim, Masayuki Shiozawa, Masatoshi Koga, Linxin Li, Caroline Lovelock, Hugues Chabriat, Michael Hennerici, Yuen Kwun Wong, Henry Ka Fung Mak, Luis Prats-Sanchez, Alejandro Martínez-Domeño, Shigeru Inamura, Kazuhisa Yoshifuji, Ethem Murat Arsava, Solveig Horstmann, Jan Purrucker, Bonnie Yin Ka Lam, Adrian Wong, Young Dae Kim, Tae-Jin Song, Robin Lemmens, Sebastian Eppinger, Thomas Gattringer, Ender Uysal, Zeynep Tanriverdi, Natan M Bornstein, Einor Ben Assayag, Hen Hallevi, Jeremy Molad, Masashi Nishihara, Jun Tanaka, Shelagh B Coutts, Alexandros Polymeris, Benjamin Wagner, David J Seiffge, Philippe Lyrer, Ale Algra, L Jaap Kappelle, Rustam Al-Shahi Salman, Hans R Jäger, Gregory Y H Lip, Urs Fischer, Marwan El-Koussy, Jean-Louis Mas, Laurence Legrand, Christopher Karayiannis, Thanh Phan, Sarah Gunkel, Nicolas Christ, Jill Abrigo, Thomas Leung, Winnie Chu, Francesca Chappell, Stephen Makin, Derek Hayden, David J Williams, Werner H Mess, Paul J Nederkoorn, Carmen Barbato, Simone Browning, Kim Wiegertjes, Anil M Tuladhar, Noortje Maaijwee, Anne Cristine Guevarra, Chathuri Yatawara, Anne-Marie Mendyk, Christine Delmaire, Sebastian Köhler, Robert van Oostenbrugge, Ying Zhou, Chao Xu, Saima Hilal, Bibek Gyanwali, Christopher Chen, Min Lou, Julie Staals, Régis Bordet, Nagaendran Kandiah, Frank-Erik de Leeuw, Robert Simister, Jeroen Hendrikse, Peter J Kelly, Joanna Wardlaw, Yannie Soo, Felix Fluri, Velandai Srikanth, David Calvet, Simon Jung, Vincent I H Kwa, Stefan T Engelter, Nils Peters, Eric E Smith, Hideo Hara, Yusuke Yakushiji, Dilek Necioglu Orken, Franz Fazekas, Vincent Thijs, Ji Hoe Heo, Vincent Mok, Roland Veltkamp, Hakan Ay, Toshio Imaizumi, Beatriz Gomez-Anson, Kui Kai Lau, Eric Jouvent, Peter M Rothwell, Kazunori Toyoda, Hee-Joon Bae, Joan Marti-Fabregas, David J Werring
Journal: The Lancet Neurology (2021)
Prevalence of RT-qPCR-detected SARS-CoV-2 infection at schools: First results from the Austrian School-SARS-CoV-2 prospective cohort study
Authors: Peter Willeit, Robert Krause, Bernd Lamprecht, Andrea Berghold, Buck Hanson, Evelyn Stelzl, Heribert Stoiber, Johannes Zuber, Robert Heinen, Alwin Köhler, David Bernhard, Wegene Borena, Christian Doppler, Dorothee von Laer, Hannes Schmidt, Johannes Pröll, Ivo Steinmetz, Michael Wagner
Journal: The Lancet Regional Health - Europe (2021)

The role of schools in the SARS-CoV-2 pandemic is much debated. We aimed to quantify reliably the prevalence of SARS-CoV-2 infections at schools detected with reverse-transcription quantitative polymerase-chain-reaction (RT-qPCR).This nationwide prospective cohort study monitors a representative sample of pupils (grade 1-8) and teachers at Austrian schools throughout the school year 2020/2021. We repeatedly test participants for SARS-CoV-2 infection using a gargling solution and RT-qPCR. We herein report on the first two rounds of examinations. We used mixed-effects logistic regression to estimate odds ratios and robust 95% confidence intervals (95% CI).We analysed data on 10,734 participants from 245 schools (9465 pupils, 1269 teachers). Prevalence of SARS-CoV-2 infection increased from 0·39% at round 1 (95% CI 028-0·55%, 28 September-22 October 2020) to 1·39% at round 2 (95% CI 1·04-1·85%, 10-16 November). Odds ratios for SARS-CoV-2 infection were 2·26 (95% CI 1·25-4·12, P = 0·007) in regions with >500 vs. ≤500 inhabitants/km2, 1·67 (95% CI 1·42-1·97, P<0·001) per two-fold higher regional 7-day community incidence, and 2·78 (95% CI 1·73-4·48, P<0·001) in pupils at schools with high/very high vs. low/moderate social deprivation. Associations of regional community incidence and social deprivation persisted in a multivariable adjusted model. Prevalence did not differ by average number of pupils per class nor between age groups, sexes, pupils vs. teachers, or primary (grade 1-4) vs. secondary schools (grade 5-8).This monitoring study in Austrian schools revealed SARS-CoV-2 infection in 0·39%-1·39% of participants and identified associations of regional community incidence and social deprivation with higher prevalence.BMBWF Austria.
Tumor microenvironment in esophageal adenocarcinoma: A fight between immunity and tolerance
Authors: Francesca Milano, Agnieszka Rygiel, Jacques Bergman, Martien Kapsenberg, Maikel Peppelenbosch, Kausilia Krishnadath
Journal: Cancer Research (2007)

229  The efficacy of therapeutic Dendritic Cell vaccination against cancer to raise an anti-tumour T-cell response has recently been questioned because of the limited rate of clinical outcomes. It has been demonstrated that in cancer patients the immune system is tolerant to tumour growth and metastasis and it is speculated that one of the reason for this phenomenon is the immune-suppressive tumour microenvironment. Immune suppression can be mediated by several growth factors and cytokines that impair adequate immune responses.  The main goal of this study is to gain insight in the immunologic tumour environment of esophageal adenocarcinomas by determining the expression of several growth modulating factors, and assessing the cytokine profile.  To this aim, biopsies of both tumour and normal tissues were collected during endoscopy procedure from 14 esophageal adenocarcinoma patients, snap frozen and used either to stain them for the factors: HER-2, COX-2, VEGF, TGF-beta, Indoleamine 2,3-Dyoxigenase (IDO), CXCR1 and CXCL3, using fluorescent immuno-histochemistry, or to isolate RNA to measure mRNA levels of several cytokines, such as IL6, IL10, IL12, IL8, IL1-beta by quantitative PCR (Taqman), or to obtain lysates to measure cytokine protein levels by performing cytometric bead array (CBA).  Immunohistochemistry showed that HER-2, COX-2, VEGF, and TGF-beta expression is up-regulated in the tumour biopsies in 80% of the patients analyzed, as compared to the expression in the normal biopsies. IDO expression was significantly higher in tumour tissues as compared to normal tissues in 90% of the patients analyzed, as well as the CXCR1 and CXCL3.  CBA assay showed that IL-8 and IL-1 beta levels are significantly higher in the tumour tissues compared to normal tissues, in 13 (90%) and 8 (60%) of the cases respectively. IL-6 was up-regulated only in 6 of the cases (28%) and IL-10, IL-12, IL-4, TNF-alpha and IFN-gamma were not detected in any of the tumour as not in the normal lysates. Quantitative PCR using Taqman confirmed that IL-8 mRNA level is significantly higher in the tumor of 90% of the cases, and significantly lower in the normal biopsies, whereas analysis of the mRNA levels of IL-6, IL-1 beta, IL-10 and IL-12 didn’t prove any expression neither in normal nor in tumor tissues.  From these results, we conclude that tumour environment is characterized by a lack of molecules enhancing the immune-response against cancer, and by a wide range of immuno-suppressive growth factors and cytokines. For future treatment of patients with immunotherapy it will be of importance to combine this strategy with tumour environment modulating agents in order to achieve a powerful immunogenic environment that may significantly improve tumour response.
P24.06 Real World use of Cisplatin and Carboplatin Based Therapy in Patients with Malignant Pleural Mesothelioma (MPM)
Authors: S. Cedres, J.D. Assaf, P. Iranzo, A. Callejo, N. Pardo, A. Navarro, A. Martinez-Marti, A. Valdivia, F. Filipi-Arriaga, V. Monton, J. Gonzalo, A. Pedrola, S. Recasens, R. Madrenas, B. Feliu, B. Roman, R. Dienstmann, E. Felip
Journal: Journal of Thoracic Oncology (2021)
Acute respiratory distress syndrome is associated with impaired alveolar macrophage efferocytosis
Authors: Rahul Y. Mahida, Aaron Scott, Dhruv Parekh, Sebastian T. Lugg, Rowan S. Hardy, Gareth G. Lavery, Michael A. Matthay, Babu Naidu, Gavin D. Perkins, David R. Thickett
Journal: European Respiratory Journal (2021)

<b>ARDS patients have decreased alveolar macrophage efferocytosis, which is associated with increased alveolar inflammation, and may contribute to worse clinical outcomes, including mortality. Upregulation of efferocytosis may offer a therapeutic strategy.</b>https://bit.ly/2Q7REdM
Robust antibody responses in 70–80-year-olds 3 weeks after the first or second doses of Pfizer/BioNTech COVID-19 vaccine, United Kingdom, January to February 2021
Authors: Sathyavani Subbarao, Lenesha A Warrener, Katja Hoschler, Keith R Perry, Justin Shute, Heather Whitaker, Michelle O’Brien, Frances Baawuah, Paul Moss, Helen Parry, Shamez N Ladhani, Mary E Ramsay, Kevin E Brown, Gayatri Amirthalingam
Journal: Eurosurveillance (2021)

Sera were collected from 185 adults aged ≥ 70 years in London to evaluate the immune response to COVID-19 vaccines. A single dose of Pfizer/BioNtech vaccine resulted in &gt; 94% seropositivity after 3 weeks in naïve individuals using the Roche Spike antibody assay, while two doses produced very high spike antibody levels, significantly higher than convalescent sera from mild-to-moderate PCR-confirmed adult cases. Our findings support the United Kingdom’s approach of prioritising the first dose and delaying the second dose of COVID-19 vaccine.
P48.10 Chemo-Immunotherapy in the Frontline of Extensive-Stage Small Cell Lung Cancer: A Systematic Review and Indirect Comparisons
Authors: A. Galvano, V. Gristina, N. Barraco, A. Perez, M. Castiglia, M. La Mantia, S. Cutaia, F. Iacono, L. Castellana, L. Insalaco, M. Bono, M. Peri, G. Madonia, S. Cusenza, S. Rizzo, V. Bazan, A. Russo
Journal: Journal of Thoracic Oncology (2021)
P09.07 Oncologists Practices and Perceptions on Management of Brain Metastases from Non-Small Cell Lung Cancers-: A Nationally Representative Survey
Authors: S. Chilukuri, P. Panda, N. Ghadyalpatil, M. Bang, N. Burela, T. Raja, R. Jalali, P. Parikh
Journal: Journal of Thoracic Oncology (2021)
Deep neural network ensemble for on-the-fly quality control-driven segmentation of cardiac MRI T1 mapping
Authors: Evan Hann, Iulia A. Popescu, Qiang Zhang, Ricardo A. Gonzales, Ahmet Barutçu, Stefan Neubauer, Vanessa M. Ferreira, Stefan K. Piechnik
Journal: Medical Image Analysis (2021)

Recent developments in artificial intelligence have generated increasing interest to deploy automated image analysis for diagnostic imaging and large-scale clinical applications. However, inaccuracy from automated methods could lead to incorrect conclusions, diagnoses or even harm to patients. Manual inspection for potential inaccuracies is labor-intensive and time-consuming, hampering progress towards fast and accurate clinical reporting in high volumes. To promote reliable fully-automated image analysis, we propose a quality control-driven (QCD) segmentation framework. It is an ensemble of neural networks that integrate image analysis and quality control. The novelty of this framework is the selection of the most optimal segmentation based on predicted segmentation accuracy, on-the-fly. Additionally, this framework visualizes segmentation agreement to provide traceability of the quality control process. In this work, we demonstrated the utility of the framework in cardiovascular magnetic resonance T1-mapping - a quantitative technique for myocardial tissue characterization. The framework achieved near-perfect agreement with expert image analysts in estimating myocardial T1 value (r=0.987,p<.0005; mean absolute error (MAE)=11.3ms), with accurate segmentation quality prediction (Dice coefficient prediction MAE=0.0339) and classification (accuracy=0.99), and a fast average processing time of 0.39 second/image. In summary, the QCD framework can generate high-throughput automated image analysis with speed and accuracy that is highly desirable for large-scale clinical applications.
No More Surprises — New Legislation on Out-of-Network Billing
Authors: Karan R. Chhabra, Erin Fuse Brown, Andrew M. Ryan
Journal: New England Journal of Medicine (2021)

Interview with Dr. Andrew Ryan on new legislation to prevent patients from receiving large and unexpected medical bills. (11:56)Download The passage of the federal No Surprises Act — which banned "surprise billing" in many scenarios — was an unexpected step forward. The new legislation will benefit patients and may have little effect on most physicians who don't engage in surprise billing.
P76.79 Osimertinib in Poor PS Patients with T790M-Positive Advanced NSCLC after Progression of EGFR TKI Treatments (NEJ032B)
Authors: R. Saito, Y. Tsubata, A. Nakamura, H. Yoshioka, M. Morita, R. Honda, N. Kanaji, M. Watanabe, D. Jingu, T. Nakagawa, K. Nakazawa, A. Mouri, S. Takeuchi, N. Furuya, Y. Akazawa, K. Miura, E. Ichihara, K. Kobayashi, S. Morita, T. Isobe
Journal: Journal of Thoracic Oncology (2021)
P35.20 Genomic Profiling and PD-L1 Expression Association Analysis in Epstein-Barr Virus (EBV)-infected Lung Cancer Patients
Authors: X. Yang, T. Mu, W. Liao, T. Huang, X. Zhang, Q. Yang, J. Duan, S. Chen, J. Fan
Journal: Journal of Thoracic Oncology (2021)
Abstract 16574: Different Anisotropic Biomechanical Behavior of Left and Right Ventricles in Adult Sheep
Authors: Wenqiang Liu, Michael Nguyen-Truong, Kevin M Labus, Elisabeth Gray, Kirk McGilvray, Christian M Puttlitz, Zhijie Wang
Journal: Circulation (2018)

Introduction: Ventricular dysfunction (VD) contributes significantly to mortality and morbidity in the modern society and is the most common cause of heart failure. Right and left ventricles (RV, L...
The Asia-Pacific League of Associations for Rheumatology consensus statements on the management of systemic lupus erythematosus
Authors: Chi Chiu Mok, Laniyati Hamijoyo, Nuntana Kasitanon, Der Yuan Chen, Sheng Chen, Kunihiro Yamaoka, Kenji Oku, Meng Tao Li, Leonid Zamora, Sang-Cheol Bae, Sandra Navarra, Eric F Morand, Yoshiya Tanaka
Journal: The Lancet Rheumatology (2021)
SARS-CoV-2 infection and transmission in primary schools in England in June–December, 2020 (sKIDs): an active, prospective surveillance study
Authors: Shamez N Ladhani, Frances Baawuah, Joanne Beckmann, Ifeanichukwu O Okike, Shazaad Ahmad, Joanna Garstang, Andrew J Brent, Bernadette Brent, Jemma Walker, Nick Andrews, Georgina Ireland, Felicity Aiano, Zahin Amin-Chowdhury, Louise Letley, Jessica Flood, Samuel E I Jones, Ray Borrow, Ezra Linley, Maria Zambon, John Poh, Vanessa Saliba, Gayatri Amirthalingam, Jamie Lopez Bernal, Kevin E Brown, Mary E Ramsay
Journal: The Lancet Child & Adolescent Health (2021)
BPI21-008: Patient Preferences and Treatment Adherence to Adjuvant Ovarian Suppression Among Premenopausal Women With Hormone Receptor Positive Breast Cancer
Authors: Jasmine Singh Sukumar, Dionisia Quiroga, Mahmoud Kassem, Michael Grimm, Namrata Vilas Shinde, Leslie Appiah, Marilly Palettas, Julie Stephens, Mathew Cherian, Daniel Stover, Nicole Williams, Jeffrey Van Deusen, Robert Wesolowski, Maryam Lustberg, Bhuvaneswari Ramaswamy, Sagar Sardesai
Journal: Journal of the National Comprehensive Cancer Network (2021)

"BPI21-008: Patient Preferences and Treatment Adherence to Adjuvant Ovarian Suppression Among Premenopausal Women With Hormone Receptor Positive Breast Cancer" published on 17 Mar 2021 by National Comprehensive Cancer Network.
P37.15 Prevalence of Targetable Mutations using a RT-qPCR Multiplex Assay in Asian NSCLC Patients: A Single Laboratory Experience
Authors: S.F. Nyaw, K. Lee, T.W. Lai, P.Y. Lo, C.T. Choy, T.C. Kwong, Y.T.N. Lau, L. Lin, S.W. Lau
Journal: Journal of Thoracic Oncology (2021)
Transcatheter Tricuspid Repair With the Use of 4-Dimensional Intracardiac Echocardiography
Authors: Charles J Davidson, Sandra Abramson, Robert L Smith, Susheel K Kodali, Robert M Kipperman, Mackram F Eleid, Mark Reisman, Brian K Whisenant, Jyothy Puthumana, Dale Fowler, Paul A Grayburn, Rebecca T Hahn, Konstantinos Koulogiannis, Sorin V Pislaru, Todd Zwink, Michael Minder, Florian Deuschl, Ted Feldman, William A Gray, D Scott Lim
Journal: JACC. Cardiovascular imaging (2021)
Omalizumab responders analysis in nasal polyposis: A supplementary analysis of the co-primary endpoints of POLYP 1 and POLYP 2 trials
Authors: J. Corren, P. H. Wellings, Philippe Gevaert, Claus Bachert, J. Mullol, X. Jaumont, R. Zhao, R. Saenz, L. Islam, T. Omachi
Journal: Allergy (2020)
Abstract P38: An examination of COVID-19-related preventive behaviors by cancer status
Authors: Carrie A. Miller, Jeanine P.D. Guidry, Bernard F. Fuemmeler
Journal: Clinical Cancer Research (2021)

Abstract Purpose: To determine patterns of and factors associated with COVID-19-related preventive behaviors practiced by cancer survivors. Methods: Participants (N=897) were recruited through a commercial survey administration and sampling company, Qualtrics, in June 2020. Quota sampling was utilized to ensure the sample would consist of approximately one-third of cancer patients currently in treatment, one-third of cancer survivors not currently in treatment, and one-third of individuals without a history of cancer. Survey items collected information on socio-demographic characteristics (age, gender, race, and education attainment) and COVID-19-related preventive behaviors in the past week. Eight items focused on handwashing, avoiding contact with sick people, staying home when feeling sick, respiratory hygiene, avoiding touching face, social distancing, avoiding large gatherings, and wearing a mask were reported on a 4-point Likert scale (never to frequently). Differences between groups were assessed using one-way ANOVAs with Tukey post hoc tests. Results: Respondents were 49.6 years (SD=17.3) on average, 51.6% female, and 48.9% had a Bachelor’s degree or higher education attainment. Most respondents were White (66.7%), with 16.8% Black and 16.5% Hispanic participants. Those with no history of cancer were more likely to avoid someone ill (p&amp;lt;.01) and stay home when sick (p&amp;lt;.001) than cancer survivors not currently in treatment. However, survivors were less likely to stay home when sick than cancer patients in treatment (p=001) and less likely to avoid touching their face (p&amp;lt;.05) than those with no cancer history. Analyses are ongoing and will explore factors related to COVID-19 preventive behaviors within each group. Conclusions: There are differences in COVID-19-related preventive behaviors by cancer status. Future research should examine the factors underlying these differences and adapt prevention efforts using this information. Citation Format: Carrie A. Miller, Jeanine P.D. Guidry, Bernard F. Fuemmeler. An examination of COVID-19-related preventive behaviors by cancer status [abstract]. In: Proceedings of the AACR Virtual Meeting: COVID-19 and Cancer; 2021 Feb 3-5. Philadelphia (PA): AACR; Clin Cancer Res 2021;27(6_Suppl):Abstract nr P38.
Partha Kar: NHS progress on diversity will need regulation and fines
Authors: Partha Kar
Journal: BMJ (2021)

It’s that time of the year again—when the Workforce Race Equality Standard programme publishes its data.1 And, like clockwork, it’s also time for the annual reflections, soul searching, and pledges to improve things. In due course we’ll have webinars or perhaps a dedicated hashtag campaign on social media—someone may even throw in some TikTok videos. And then we’ll move on, until next year.

If you want to convince yourself of improvement, let your confirmation bias take over and you’ll find some bits to help you: 10% of board members in NHS trusts are now from minority ethnic backgrounds, up from 7% in 2017. And 21.0% of staff in NHS trusts and clinical commissioning groups (CCGs) in England are now from a minority ethnic background, up 2.9 percentage points since 2017. Surely cause to rejoice?

I suspect that it depends on your outlook—on whether you think that being offered crumbs from the table is a win, or that continuing with the “Please sir, may I?” …
Snare rotation technique: a simple tip for successful polypectomy for non-pedunculated gastrointestinal polyps
Authors: Shunsuke Yamamoto, Adolfo Parra-Blanco
Journal: Endoscopy (2021)

Snare resection for non-pedunculated polyps has a long history, and its application has been expanded to various methods such as endoscopic mucosal resection (EMR), cold polypectomy, and underwater EMR [1] [2] [3]. Various clinical tips and tricks have been demonstrated by experts [4] [5]. In any snare resection for non-pedunculated polyps, a universally important issue is positioning the loop of the snare horizontal to the lesion. This positioning can avoid askew grasping of the polyp, thereby avoiding incomplete resection. However, the snare does not always emerge at the desired angle from the working channel of the scope. Here we demonstrate the “rotation technique” to reposition the loop of the snare to an ideal angle for grabbing the polyp horizontally ([Video 1]).
Abstract 325: Characteristics and Outcomes of Hanging Induced Out-Of-Hospital Cardiac Arrest: Insights From the Paris Sudden Death Expertise Center Registry
Authors: Arnaud Gille, Richard Chocron, Anna Ozguler, Xavier JOUVEN, Alain Cariou, Florence Dumas, Eloi Marijon, Wulfran Bougouin, frederic adnet, daniel jost, Lionel Lamhaut, Eric Lecarpentier, Michel Baer, Charles Groizard, Thomas Loeb
Journal: Circulation (2019)

Introduction: Hanging-induced Out-of-Hospital cardiac arrest (OHCA) is poorly studied and a better understanding of these specific OHCA could be helpful to improve patients’ outcome. The main objective of our study was to describe characteristics and outcomes in patients who had OHCA from hanging injuries. Methods: From May 2011 to December 2017 we analyzed a prospectively collected Utstein database for all OHCA adults. All cases due to hanging were included. Utstein style variables were compared for 2 groups of patients: those with a Return of Spontaneous Circulation (ROSC) and those without (non-ROSC). Continuous data are described as means (extremes). Results: Among 25 055 OHCA, 500 patients were included. They were 49 (18-100) years old. Seventy-three (14.6%) hanging were witnessed and 58 (11.6%) benefited from a bystander cardiopulmonary resuscitation before Emergency Medical Service (EMS) arrival. No-flow duration was 29.1 (4-180) minutes. Advance life support was initiated by EMS in 299 (59.8%) cases. Low-flow duration was 23.8 (2-79) minutes. Nine patients (1.8%) had a shockable initial rhythm. We observed 83 (16.6%) ROSC. Four (0.8%) patients were discharged alive from hospital. They were all CPC 1. Table 1 compares characteristics with significant differences between ROSC and non-ROSC groups. Conclusion: As expected, younger age, short no-flow and low-flow durations and shockable rhythm on EMS arrival were significantly associated with ROSC. Overall prognosis is dramatically poor when OHCA is due to hanging (&lt;1%), with a very low proportion of shockable rhythm, even if the rare survivors have an excellent CPC at discharge. Indeed, the best method to reduce the mortality rate of hanging is, with no contest, the prevention of suicidal act.