tbuckley/cabot-search huggingface dataset:
Inhibition by acetylcholine of the norepinephrine release evoked by potassium in canine saphenous veins.
Authors: P MVanhoutee, T JVerbeuren
Journal: Circulation Research (1976)

In the dog's saphenous vein acetylcholine inhibits the norepinephrine release caused by nerve stimulation, but not that caused by tyramine. Experiments were performed to determine whether acetylcholine affects the release of norepinephrine evoked by high K+ concentrations. We recorded changes in isometric tension of dog saphenous vein strips. Acetylcholine (5 X 10(-9) to 10(-6) g/ml) caused dose-dependent relaxations during contractions caused by K+ = 40 mEq/liter. These relaxations were not depressed by tetrodotoxin (10(-7) g/ml), which abolished the response to nerve stimulation, but were inhibited by atropine (10(-7) g/ml). Strips of saphenous veins were incubated with [3H]norepinephrine and mounted for superfusion (3 ml/min) and isometric tension recording; the total radioactivity and the amount of intact [3H]norepinephrine present in the superfusate were determined. K+ at 50 mEq/liter increased tension, total radioactivity of the superfusate, and the [3H]norepinephrine afflux; acetylocholine (10(-7) ...
Cellular mechanisms of differential action potential duration restitution in canine ventricular muscle cells during single versus double premature stimuli.
Authors: YKobayashi, WPeters, S SKhan, W JMandel, H SKaragueuzian
Journal: Circulation (1992)

BACKGROUNDWe tested the hypothesis that action potential duration (APD) restitution of normal ventricular muscle cells is different during double premature stimuli (S3) compared with a single premature stimulus (S2). We propose a possible ionic mechanism for such a difference.METHODS AND RESULTSAction potentials and isometric tension were recorded simultaneously from isolated canine right ventricular trabeculae (2 x 2 x 10 mm) (n = 35). APD and tension restitution curves (APD) and peak tension versus diastolic interval [DI] of S2 and S3 were constructed by the extrastimulus method during pacing at 1,500 msec. The following results were obtained. 1) The APD restitution curve of S2 was different from that of S3. During the restitution of S2, an early biphasic upward hump was present at short DIs. In contrast, a smooth exponential rise was consistently seen during S3 restitution. 2) Peak tension remained significantly (p less than 0.001) lower during the restitution of S2 than during S3 restitution at all DI...
Fetal atrioventricular valve insufficiency associated with nonimmune hydrops: a two-dimensional echocardiographic and pulsed Doppler ultrasound study.
Authors: N HSilverman, C SKleinman, A MRudolph, J ACopel, E MWeinstein, M AEnderlein, MGolbus
Journal: Circulation (1985)

Of 466 fetuses who underwent cardiac ultrasound examination with cross-sectional and M mode echocardiography and pulsed Doppler ultrasound and in whom we were able to follow the natural history, 12 were found to have atrioventricular valve insufficiency and nonimmune hydrops. Eleven fetuses (all of whom had structural heart disease) died either in utero or during the early postnatal period. In the one surviving hydropic fetus with supraventricular tachyarrhythmia and atrioventricular valve regurgitation but without structural heart disease, all the abnormalities disappeared on treatment with digoxin and verapamil. Seven fetuses who had atrioventricular valve insufficiency but did not develop nonimmune hydrops all survived pregnancy and the early neonatal period. The syndrome of atrioventricular valve insufficiency, nonimmune hydrops, and structural heart disease has a poor prognosis. The hydrops in this instance reflects fetal cardiac failure related to venous hypertension and low colloid oncotic pressure.
Response by de Veer et al to Letter Regarding Article, “Efficacy and Safety of the Use of Non–Vitamin K Antagonist Oral Anticoagulants in Patients With Nonvalvular Atrial Fibrillation and Concomitant Aspirin Therapy: A Meta-Analysis of Randomized Trials”
Authors: Anne J.W.M. de Veer, Naoual Bennaghmouch, Bakhtawar K. Mahmoodi, Jurriën M. ten Berg
Journal: Circulation (2018)
A comparison of calcium currents in rat and guinea pig single ventricular cells.
Authors: I RJosephson, JSanchez-Chapula, A MBrown
Journal: Circulation Research (1984)

The slow inward calcium currents were compared in rat and guinea pig heart using enzymatically dissociated, single ventricular cells. A single electrode voltage clamp was used, in which current and voltage were sampled separately using a time-sharing method. Spatial homogeneity of membrane potential during peak slow inward calcium current was assessed by measuring the potential with two microelectrodes 50 micron apart; the potentials were within 3 mV of each other. Peak current-voltage relations for slow inward calcium currents were similar for the two species, but the individual currents showed a faster time course of inactivation and a slower time course of recovery from inactivation for rat, compared with guinea pig. The potassium current blockers 4-aminopyridine and tetraethylammonium chloride did not produce significant effects on the net membrane currents recorded at the holding potentials (-50 to -40 mV) used in this study. The underlying mechanism for the inactivation of the slow inward calcium cu...
mRNALocater: Enhance the prediction accuracy of eukaryotic mRNA subcellular localization by using model fusion strategy
Authors: Qiang Tang, Fulei Nie, Juanjuan Kang, Wei Chen
Journal: Molecular Therapy (2021)

The functions of mRNAs are closely correlated with their locations in cells. Knowledge about the subcellular locations of mRNA is helpful to understand their biological functions. In recent years, it has become a hot topic to develop effective computational models to predict eukaryotic mRNA subcellular localizations. However, existing state-of-the-art models still have certain deficiencies in terms of prediction accuracy and generalization ability. Therefore, it is urgent to develop novel methods to accurately predict mRNA subcellular localizations. In this study, a novel method called mRNALocater was proposed to detect the subcellular localization of eukaryotic mRNA by adopting the model fusion strategy. To fully extract information from mRNA sequences, the electron-ion interaction pseudopotential and pseudo k-tuple nucleotide composition were used to encode the sequences. Moreover, the correlation coefficient filtering algorithm and feature forward search technology were used to mine hidden feature information, which guarantees that mRNALocater can be more effectively applied to new sequences. The results based on the independent dataset tests demonstrate that mRNALocater yields promising performances for predicting eukaryotic mRNA subcellular localizations and is a powerful tool in practical applications. A freely available online web server for mRNALocater has been established at http://bio-bigdata.cn/mRNALocater. The functions of mRNAs are closely correlated with their locations in cells. Knowledge about the subcellular locations of mRNA is helpful to understand their biological functions. In recent years, it has become a hot topic to develop effective computational models to predict eukaryotic mRNA subcellular localizations. However, existing state-of-the-art models still have certain deficiencies in terms of prediction accuracy and generalization ability. Therefore, it is urgent to develop novel methods to accurately predict mRNA subcellular localizations. In this study, a novel method called mRNALocater was proposed to detect the subcellular localization of eukaryotic mRNA by adopting the model fusion strategy. To fully extract information from mRNA sequences, the electron-ion interaction pseudopotential and pseudo k-tuple nucleotide composition were used to encode the sequences. Moreover, the correlation coefficient filtering algorithm and feature forward search technology were used to mine hidden feature information, which guarantees that mRNALocater can be more effectively applied to new sequences. The results based on the independent dataset tests demonstrate that mRNALocater yields promising performances for predicting eukaryotic mRNA subcellular localizations and is a powerful tool in practical applications. A freely available online web server for mRNALocater has been established at http://bio-bigdata.cn/mRNALocater.
Intubation With Video Laryngoscopy vs Direct Laryngoscopy
Authors: Daniel Saddawi-Konefka, Keith H. Baker, Jeanine P. Wiener-Kronish
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Current Medical Diagnosis and Treatment.
Journal: Annals of Internal Medicine (1978)

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The 60th anniversary edition of the most popular, relied-upon guide to internal medicine For 60 years, CURRENT Medical Diagnosis and Treatment-the flagship volume of the renowned Lange medical series-has been delivering the authoritative information students, residents, and clinicians need to build their medical knowledge, expertise, and confidence. Covering the latest clinical developments in all facets of medicine and fully focused on bedside clinical issues, this new edition provides completely the latest guidelines, reference, drug prices, approved drugs, and evidence-based coverage of more than 1,000 diseases and disorders-all formatted to enable you to find the answers you need quickly and effortlessly. This landmark guide covers inpatient and outpatient care, focusing on the diagnostic tools relevant to daily practice, and reviews all primary care topics, including gynecology/obstetrics, dermatology, ophthalmology, geriatrics, preventive medicine, psychiatry, and neurology. Now includes a year in  feature highlighting what's new in CMDT! *Includes essentials of diagnosis for most diseases/disorders *Hundreds of quick-access drug treatment tables with indexed trade names *Diagnostic and treatment algorithms present important information in an at-a-glance style *Up-to-date references provide peer-reviewed, evidence-based information *Seven bonus chapters available online to all book purchasers, featuring expanded content and annual review of advances in HIV treatment and critical information on emerging viral infections
Ketotifen in adult asthma.
Authors: A J Dyson, A D Mackay
Journal: BMJ (1980)

The efficacy and adverse effects of ketotifen 1 mg twice daily and 2 mg twice daily were compared with placebo in 50 patients with atopic asthma in a multicentre, double-blind study. Ketotifen in the higher dosage caused a slight reduction in salbutamol usage and a modest improvement in breathing in patients not already receiving inhaled corticosteroids. The drug was ineffective in patients receiving inhaled corticosteroids. Drowsiness was a troublesome effect causing withdrawal from treatment or reduction of dosage in seven patients while receiving ketotifen compared with only three while receiving placebo.
Efficacy of exercise training in patients with coronary artery disease who are taking propranolol.
Authors: L JLaslett, LPaumer, PScott-Baier, E AAmsterdam
Journal: Circulation (1983)

The effects of beta-adrenergic blockade on the efficacy of exercise training in patients with coronary artery disease were assessed in a community-based cardiac rehabilitation program. Twenty-five patients took no beta-adrenergic-blocking agent and 17 patients took a constant dose of propranolol during the 3 month study period. Individual exercise prescriptions consisted of an intensity of 70% of maximal workload monitored by heart rate, performed 20 min each session, three sessions per week. Both groups improved in maximal exercise capacity: from 8.7 +/- 1.9 (mean +/- SD) to 9.7 +/- 2.1 mets (p less than .01) in those not taking propranolol and from 6.6 +/- 1.5 to 7.7 +/- 1.8 mets (p less than .01) in those taking the drug. At a workload of 70% of maximal achieved at pretraining testing, heart rate decreased with training from 123 +/- 19 to 113 +/- 17 beats/min (p less than .01) in those not taking propranolol and from 97 +/- 14 to 92 +/- 12 beats/min (p less than .05) in those taking the drug. At a work...
Interventions to Lower Low-Density Lipoprotein Cholesterol and Cardiovascular Risk
Authors: Kamran Zafar, Maimoona Inayat
Journal: JAMA (2017)

To the Editor The article by Dr Silverman and colleagues1 discussed comparatively similar benefits of all currently available LDL-C–lowering therapies, particularly those that lower LDL-C by upregulation of LDL-C receptors or by decreasing LDL-C production, on major cardiovascular events.
NEW YORK LETTER.
Authors: None Vindex
Journal: JAMA (1884)

<h3>To the Editor of The Journal of the American Medical Association:</h3><h3>Dear Sir:</h3> In your issue of January 26, 1884, is a leader headed " An Ethical Symposium," in which you make animadversions upon the action of the Medical Society of the State of New York in amending its Code of Ethics in 1882. The argument of your leader is obviously intended to propagate the idea that the Medical Society of the State of New York voluntarily and intentionally seceded from the American Medical Association. It did not. It was extruded from membership in that body by the action of its Judicial Council at St. Paul in 1882, which action the Association, as a body, assumed by adopting the report of said Council. These and some other facts in the matter should be stated again, as your leader was evidently written by some one who either does not know them, or
Inappropriate Drug Prescribing
Authors: Daniel Krinsky
Journal: JAMA (1995)

<h3>To the Editor.</h3> —I read with great interest the article by Dr Willcox and colleagues.<sup>1</sup>It identified some very troublesome issues with regard to prescribing medication for elderly patients and concludes that "much more vigorous physician education and increased pharmaceutical regulation are needed to improve the safety of prescribing." While this may be true, there are two issues that I feel are integral to solving the problem at hand in a more timely and efficient manner. First, the primary focus of the article appeared to be on the physician and his or her responsibility in this process. There is another health professional that should assume some of the responsibilities for this problem, yet is also the most qualified to begin correcting the situation now and address the information needs of the community: your pharmacist. Pharmacists are the most extensively educated health professionals regarding drug therapy, as well as the
Increased Serum Lipoprotein(a) Levels in Patients with Early Renal Failure
Authors: José J.G. De Lima
Journal: Annals of Internal Medicine (1999)

Letters15 June 1999Increased Serum Lipoprotein(a) Levels in Patients with Early Renal FailureJosé J.G. De Lima, MDJosé J.G. De Lima, MDSão Paulo University Medical School; São Paulo SP 04623-000, Brazil (De Lima)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-12-199906150-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Sechi and colleagues' data on elevated Lp(a) levels during the early stages of renal failure (1) confirm our previous observation in a smaller group of patients (2). In contrast to their results, however, we found that Lp(a) levels do not increase further with the progression of renal insufficiency. In our patients, increased Lp(a) levels were the earliest lipid alteration detected, but these levels did not change as renal function deteriorated.References1. Sechi LA, Zingaro L, De Carli S, Sechi G, Catena C, Falleti E, et al . Increased serum lipoprotein(a) levels in patients with early renal failure. Ann Intern Med. 1998;129:457-61. LinkGoogle Scholar2. De Lima JJ, Maranhao RC, Latrilha M da C, Diament J, Romao JE, Krieger EM, et al . Early elevation of lipoprotein(a) levels in chronic renal insufficiency. Ren Fail. 1997;19:145-54. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: São Paulo University Medical School; São Paulo SP 04623-000, Brazil (De Lima) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoIncreased Serum Lipoprotein(a) Levels in Patients with Early Renal Failure Leonardo A. Sechi , Laura Zingaro , Stefano De Carli , Giovanni Sechi , Cristiana Catena , Edmondo Falleti , Elisabetta Dell'Anna , and Ettore Bartoli Increased Serum Lipoprotein(a) Levels in Patients with Early Renal Failure Leonardo A. Sechi , Laura Zingaro , and Ettore Bartoli Increased Serum Lipoprotein(a) Levels in Patients with Early Renal Failure Moses S. Elisaf , Haralampos J. Millionis , and Kostas C. Siamopoulos Metrics 15 June 1999Volume 130, Issue 12Page: 1028KeywordsLipidsRenal failure Issue Published: 15 June 1999 CopyrightCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Bedside assessment of pulmonary gas exchange in very preterm infants: a pathophysiological approach to bronchopulmonary dysplasia diagnosis?
Authors: T'ng Chang Kwok, Don Sharkey
Journal: Thorax (2021)

Bronchopulmonary dysplasia (BPD) is a leading cause of mortality and morbidity in premature infants with significant lifelong respiratory and neurodevelopmental sequelae into adulthood.1 Since it was first described in 1967, the pathophysiological understanding of BPD has evolved with advances in neonatal practice, such as the use of surfactant and maternal antenatal steroids. As the care of extremely premature infants improves, more immature infants born during the late canalicular and early saccular phases of lung development are surviving, altering the pathophysiology of BPD and diagnostic criteria.2

There is an ongoing debate on the optimal method of diagnosing and classifying BPD. The current 2018 National Institute of Child Health and Human Development BPD definition3 adopts a treatment-based, semiquantitative approach. Very premature infants with abnormal chest X-ray findings are classified into three grades of BPD depending on oxygen requirement and type of respiratory support required over three consecutive days around 36 weeks of corrected gestational age (CGA). Hence, differences in oxygen and ventilation strategies among clinicians and centres may lead to inconsistencies in BPD definition and classification.

Impaired pulmonary gas exchange is a cardinal feature of BPD. A pathophysiological-based approach in defining BPD by measuring pulmonary gas exchange in very preterm infants may offer a physiological assessment of BPD severity at the parenchymal level.2 The rightward shift of the oxyhaemoglobin dissociation …
Developmental and hormonal regulation of sarcomeric myosin heavy chain gene family.
Authors: VMahdavi, SIzumo, BNadal-Ginard
Journal: Circulation Research (1987)

Sarcomeric myosin heavy chain (MHC), the main component of the sarcomere, contains the ATPase activity that generates the contractile force of cardiac and skeletal muscles. The different MHC isoforms are encoded by a closely related multigene family. Most members (seven) of this gene family have been isolated and characterized in the rat, including the alpha- and beta-cardiac, skeletal embryonic, neonatal, fast IIA, fast IIB, and extraocular specific MHC. The slow type I skeletal MHC is encoded by the same gene that codes for the cardiac beta-MHC. Each MHC gene studied displays a pattern of expression that is tissue and developmental stage specific, both in cardiac and skeletal muscles. Furthermore, more than one MHC gene is expressed in each muscle while each gene is expressed in more than one tissue. The expression of each MHC gene in cardiac and skeletal muscles is modulated by thyroid hormone. Surprisingly, however, the same MHC gene can be regulated by the hormone in a significantly different manner,...
Endothelium-dependent contractions in rabbit pulmonary artery are mediated by thromboxane A2.
Authors: C JBuzzard, S LPfister, W BCampbell
Journal: Circulation Research (1993)

This study was designed to characterize the endothelium-dependent contracting factor (EDCF) released by arachidonic acid (AA) and methacholine (MeCH) in the rabbit pulmonary artery. AA and MeCH contract the rabbit pulmonary artery; however, the effects of both are blocked by denuding the vessels and by administration of indomethacin (a cyclooxygenase inhibitor), dazoxiben (a thromboxane [TX] synthase inhibitor), and SQ29548 (a TXA2/prostaglandin [PG] H2 receptor antagonist). When segments of rabbit pulmonary artery were incubated with [14C]AA and the [14C] metabolites were resolved by reverse-phase high-performance liquid chromatography (HPLC), radioactive products were observed that comigrated with 6-keto-PGF1 alpha and TXB2, the stable metabolites of prostacyclin and TXA2. The TXB2 radioactive peak was rechromatographed on normal-phase HPLC and again migrated with TXB2. Finally, the structures of derivatized [14C]6-keto-PGF1 alpha and [14C]TXB2 peaks were confirmed by gas chromatography/mass spectrometr...
Decreased myofilament responsiveness in myocardial stunning follows transient calcium overload during ischemia and reperfusion.
Authors: J PCarrozza, L ABentivegna, C PWilliams, R EKuntz, WGrossman, J PMorgan
Journal: Circulation Research (1992)

The purpose of this study was to test the hypothesis that abnormal intracellular calcium handling characterizes myocardial stunning. Isolated, isovolumic, buffer-perfused ferret hearts were loaded with the bioluminescent calcium indicator aequorin for simultaneous measurement of individual calcium transients and left ventricular pressure. After 15 minutes of global ischemia and 20 minutes of reperfusion, left ventricular developed pressure was significantly reduced (75 +/- 7 versus 93 +/- 6 mm Hg, p < 0.05). During ischemia, [Ca2+]i levels were significantly elevated compared with preischemic levels, both during systole (1.38 +/- 0.31 versus 0.88 +/- 0.2 microM, p < 0.05) and end diastole (0.85 +/- 0.16 versus 0.38 +/- 0.13 microM, p < 0.05). Early during reperfusion, [Ca2+]i was also significantly elevated during systole (1.63 +/- 0.44 versus 0.88 +/- 0.20 microM, p < 0.05) and end diastole (0.75 +/- 0.15 versus 0.38 +/- 0.13 microM, p < 0.05). After 20 minutes of reperfusion, myocardial stunning occurre...