tbuckley/cabot-search huggingface dataset:
Peroral endoscopic myotomy for multiple esophageal diverticula
Authors: Yong-Sheng Quan, Jun Yao, Li-Sheng Wang
Journal: Endoscopy (2022)

A 65-year-old man presented with persistent heartburn and acid reflux for 1 month, and was diagnosed with multiple esophageal diverticula in our department ([Fig. 1]). Gastroscopy identified that two consecutive esophageal diverticula located 30 cm from the incisors. In recent years, endoscopic intervention was considered to be a better option for esophageal diverticulum compared with traditional surgical resection. This patient asked for treatment to alleviate symptoms. After informed consent was obtained, the esophageal diverticulum was treated using peroral endoscopic myotomy (POEM) under general anesthesia ([Video 1]).
Pre-exposure anti-SARS-CoV-2 monoclonal antibodies in severely immunocompromised patients with immune-mediated inflammatory diseases
Authors: Tiphaine Goulenok, Laure Delaval, Nicole Delory, Chrystelle François, Thomas Papo, Diane Descamps, Valentine Marie Ferré, Karim Sacré
Journal: The Lancet Rheumatology (2022)
Covid-19: Hospital and ambulance services struggle with huge demand and staff illness
Authors: Elisabeth Mahase
Journal: BMJ (2022)

Covid-19: Hospital and ambulance services struggle with huge demand and staff illness Elisabeth MahaseHospitals and ambulance services in England are facing "extreme pressures" and a high volume of staff absences, forcing some to declare critical incidents and others to warn of 12 hour waits for patients in hospital emergency departments.
TCTAP C-148 The Masquerading Pickering; In-stent Restenosis of Renal Artery Stenting With Contralateral Renal Artery Stenosis Presenting With Flash Acute Pulmonary Edema
Authors: Shawal Faizal Mohamad, Muhammad Shamill Bin Shamsul Ismail, Mohd Asyiq Al-Fard Bin Mohd Raffali, Diyana Farouk, Rosli Mohd Ali, Hamat Hamdi Che Hassan
Journal: Journal of the American College of Cardiology (2022)
Association of Medical Assistant–Supported Virtual Rooming With Successful Video Visit Connections
Authors: Tracy A. Lieu, E. Margaret Warton, Christine Levan, Karen San, Loretta Hsueh, Sameer Awsare, Mary E. Reed
Journal: JAMA Internal Medicine (2022)

Association of Medical Assistant-Supported Virtual Rooming With Successful Video Visit ConnectionsCOVID-19 pandemic-related increases in physician video visit availability have created new opportunities but may engender inequities.Patients who have lower socioeconomic status (SES), low English proficiency, or are African American or Black or Latino are less likely to use video visits successfully. [1]][3] Limited information exists to guide systems on bridging this "digital divide.
Targeting FcγRIIB by antagonistic antibody BI-1206 improves the efficacy of rituximab-based therapies in aggressive mantle cell lymphoma
Authors: Vivian Changying Jiang, Yang Liu, Alexa Jordan, Angela Leeming, Joseph McIntosh, Shengjian Huang, Rongjia Zhang, Qingsong Cai, Zhihong Chen, Yijing Li, Yuxuan Che, Lei Nie, Ingrid Karlsson, Linda Mårtensson, Mathilda Kovacek, Ingrid Teige, Björn Frendéus, Michael Wang
Journal: Journal of Hematology & Oncology (2022)

Abstract Inevitable relapses remain as the major therapeutic challenge in patients with mantle cell lymphoma (MCL) despite FDA approval of multiple targeted therapies and immunotherapies. Fc gamma receptors (FcγRs) play important roles in regulating antibody-mediated immunity. FcγRIIB, the unique immune-checkpoint inhibitory member of the FcγR family, has been implicated in immune cell desensitization and tumor cell resistance to the anti-CD20 antibody rituximab and other antibody-mediated immunotherapies; however, little is known about its expression and its immune-modulatory function in patients with aggressive MCL, especially those with multi-resistance. In this study, we found that FcγRIIB was ubiquitously expressed in both MCL cell lines and primary patient samples. FcγRIIB expression is significantly higher in CAR T-relapsed patient samples ( p &lt; 0.0001) compared to ibrutinib/rituximab-naïve, sensitive or resistant samples. Rituximab-induced CD20 internalization in JeKo-1 cells was completely blocked by concurrent treatment with BI-1206, a recombinant human monoclonal antibody targeting FcγRIIB. Combinational therapies with rituximab-ibrutinib, rituximab-venetoclax and rituximab-CHOP also induced CD20 internalization which was again effectively blocked by BI-1206. BI-1206 significantly enhanced the in vivo anti-MCL efficacy of rituximab-ibrutinib ( p = 0.05) and rituximab-venetoclax ( p = 0.02), but not the rituximab-CHOP combination in JeKo-1 cell line-derived xenograft models. In patient-derived xenograft (PDX) models, BI-1206, as a single agent, showed high potency ( p &lt; 0.0001, compared to vehicle control) in one aggressive PDX model that is resistant to both ibrutinib and venetoclax but sensitive to the combination of rituximab and lenalidomide (the preclinical mimetic of R 2 therapy). BI-1206 sensitized the efficacy of rituximab monotherapy in a PDX model with triple resistance to rituximab, ibrutinib and CAR T-therapies ( p = 0.030). Moreover, BI-1206 significantly enhanced the efficacy of the rituximab-venetoclax combination ( p &lt; 0.05), which led to long-term tumor remission in 25% of mice. Altogether, these data support that targeting this new immune-checkpoint blockade enhances the therapeutic activity of rituximab-based regimens in aggressive MCL models with multi-resistance. Graphical Abstract
TCTAP C-010 Primary PCI in a Patient With Multiple Organ Failure: Is There Room for Complete Revascularization in the Index Procedure?
Authors: Nicolaus Novian Dwiya Wahjoepramono, Antonia Anna Lukito, Riyandi Ardi Putra Fernandes, Sonia Chandra, Indah Sukmawati
Journal: Journal of the American College of Cardiology (2022)
TCTAP C-146 Successful Revascularization Using Extreme Antegrade Guidewire Crossing by Anteowl Wr Intravascular Ultrasound Guided Parallel Wiring for Poor Run-Off Cases of Continuous Occlusion From Superficial Femoral Artery to Below the Knee Artery
Authors: Naoki Hayakawa
Journal: Journal of the American College of Cardiology (2022)
TCTAP A-058 The Diagnostic Precision of Monoenergetic Reconstructions Using Dual-Source Dual-Energy CT Compared to Invasive Coronary Angiography With Add on Intravascular Ultrasound to Evaluate In-Stent Restenosis: Cross-Sectional Study
Authors: Mohey Eldeen AbouElfetouh Eldeeb, Mohamed Mostafa, Tarek Ahmed Naguib, Mohammed Hosam Eldein Alshair, Islam Elsayed Shehata
Journal: Journal of the American College of Cardiology (2022)
Machine learning and semi-targeted lipidomics identify distinct serum lipid signatures in hospitalized COVID-19-positive and COVID-19-negative patients
Authors: Helena Castañé, Simona Iftimie, Gerard Baiges-Gaya, Elisabet Rodríguez-Tomàs, Andrea Jiménez-Franco, Ana Felisa López-Azcona, Pedro Garrido, Antoni Castro, Jordi Camps, Jorge Joven
Journal: Metabolism (2022)
Analysis of Aspirin Use and Cardiovascular Events and Mortality Among Adults With Hypertension and Controlled Systolic Blood Pressure
Authors: Rita Del Pinto, Davide Pietropaoli, Giovambattista Desideri, Claudio Ferri
Journal: JAMA Network Open (2022)

association with decreased ASCVD risk in the examined context. 6Long-term data on aspirin use in combination with emerging therapies for cardiovascular prevention may clarify the future role of this pivotal drug in similar clinical settings.
TCTAP C-115 Use of Biopsy Forceps: A Novel Method of Dislodged Stent Retrieval
Authors: Jian-Chen Lim, Glendon Seng Lau, Ping Lik Chua, Julian Tey, Faizal Khan Bin Abdullah, Kamaraj Selvaraj
Journal: Journal of the American College of Cardiology (2022)
A Phase Ib/II Study of Sabizabulin, a Novel Oral Cytoskeleton Disruptor, in Men with Metastatic Castration-resistant Prostate Cancer with Progression on an Androgen Receptor–targeting Agent
Authors: Mark C. Markowski, Ronald Tutrone, Christopher Pieczonka, K. Gary Barnette, Robert H. Getzenberg, Domingo Rodriguez, Mitchell S. Steiner, Daniel R. Saltzstein, Mario A. Eisenberger, Emmanuel S. Antonarakis
Journal: Clinical Cancer Research (2022)

Sabizabulin, an oral cytoskeleton disruptor, was tested in a phase Ib/II clinical study in men with metastatic castration-resistant prostate cancer (mCRPC).The phase Ib portion utilized a 3+3 design with escalating daily oral doses of 4.5-81 mg and increasing schedule in 39 patients with mCRPC treated with one or more androgen receptor-targeting agents. Prior taxane chemotherapy was allowed. The phase II portion tested a daily dose of 63 mg in 41 patients with no prior chemotherapy. Efficacy was assessed using PCWG3 and RECIST 1.1 criteria.The MTD was not defined in the phase Ib and the recommended phase II dose was set at 63 mg/day. The most common adverse events (>10% frequency) at the 63 mg oral daily dosing (combined phase Ib/II data) were predominantly grade 1-2 events. Grade ≥3 events included diarrhea (7.4%), fatigue (5.6%), and alanine aminotransferase/aspartate aminotransferase elevations (5.6% and 3.7%, respectively). Neurotoxicity and neutropenia were not observed. Preliminary efficacy data in patients treated with ≥1 continuous cycle of 63 mg or higher included objective response rate in 6 of 29 (20.7%) patients with measurable disease (1 complete, 5 partial) and 14 of 48 (29.2%) patients had PSA declines. The Kaplan-Meier median radiographic progression-free survival was estimated to be 11.4 months (n = 55). Durable responses lasting >2.75 years were observed.This clinical trial demonstrated that chronic oral daily dosing of sabizabulin has a favorable safety profile with preliminary antitumor activity. These data support the ongoing phase III VERACITY trial of sabizabulin in men with mCRPC.
De-escalated neoadjuvant pertuzumab plus trastuzumab therapy with or without weekly paclitaxel in HER2-positive, hormone receptor-negative, early breast cancer (WSG-ADAPT-HER2+/HR–): survival outcomes from a multicentre, open-label, randomised, phase 2 trial
Authors: Ulrike Nitz, Oleg Gluz, Monika Graeser, Matthias Christgen, Sherko Kuemmel, Eva-Maria Grischke, Michael Braun, Doris Augustin, Jochem Potenberg, Katja Krauss, Claudia Schumacher, Helmut Forstbauer, Toralf Reimer, Andrea Stefek, Hans Holger Fischer, Enrico Pelz, Christine zu Eulenburg, Ronald Kates, Rachel Wuerstlein, Hans Heinrich Kreipe, Nadia Harbeck, Raquel von Schumann, Walther Kuhn, Silke Polata, Wojciech Bielecki, Ralf Meyer, Marianne Just, Susanne Kraudelt, Wulf Siggelkow, Heidi Wortelmann, Anke Kleine-Tebbe, Lena Leitzen, Heidrun Kirchhof, Petra Krabisch, John Hackmann, Reinhard Depenbusch, Karsten Gnauert, Peter Staib, Antje Lehnert, Oliver Hoffmann, Susanne Briest, Christoph Lindner, Volker Heyl, Leila Bauer, Christoph Uleer, Svjetlana Mohrmann, Nicole Viehstaedt, Wolfram Malter, Theresa Link, Nana Buendgen, Joke Tio
Journal: The Lancet Oncology (2022)
Large US Study Examines First 6 Months of COVID-19 Vaccine Safety Data
Authors: Jennifer Abbasi
Journal: JAMA (2022)

Vaccine Booster Dose Appears to Reduce Omicron HospitalizationsThe COVID-19 mRNA vaccines' 2-dose primary series appeared to provide less protection against hospitalization from Omicron variant infections than Alpha and Delta infections, according to a recent study.A booster dose, however, was associated with increased effectiveness against Omicron hospitalizations at the same high levels achieved against earlier variants with 2 doses.The study included data from 11 690 adults admitted to 21 US hospitals from March 11, 2021, to January 14, 2022, about half of whom had laboratory-confirmed COVID-19.The other half served as a control group.To calculate vaccine effectiveness, researchers compared the odds of vaccination between the 2 groups.In the COVID-19 group, SARS-CoV-2 variants were determined using whole-genome sequencing or were classified based on the predominant variant at the time of hospitalization.Sequencing results were available for 45.4% of the 5728 SARS-CoV-2 infections.The effectiveness of 2 vaccine doses against hospitalization was 85% during the periods of the study when Alpha and Delta dominated but 65% during the Omicron period-late December 2021 through mid-January 2022.The effectiveness of 3 vaccine doses during the Omicron phase was 86%.Regardless of which strain was circulating at the time, COVID-19 severity, based on the World Health Organization clinical progression scale, was lower for vaccinated than for unvaccinated patients.Vaccination, including 2 or 3 doses, was 76% effective for preventing progression to invasive mechanical ventilation or death with the Alpha variant and around 45% effective with Delta or Omicron infections.The findings appeared in the BMJ.
ΔF659 and F659S substitutions at the HS1 of FKS2 gene, along with E655A and W715L upstream and downstream substitutions, correlate with high ibrexafungerp MICs against Candida glabrata
Authors: Aina Mesquida, Judith Díaz-García, Carlos Sánchez-Carrillo, Pablo Martín-Rabadán, Luis Alcalá, Patricia Muñoz, Pilar Escribano, Jesús Guinea
Journal: Clinical Microbiology and Infection (2022)
TCTAP A-057 Prone Contrast Enhancement Computed Tomography Angiography Protocol to Diagnose Concealed Endoleak and Aortic Sac Hygroma
Authors: Sherif Sultan, Yogesh Acharya, Hesham Elzomor, Juan Parodi, Niamh Hynes, Osama Soliman
Journal: Journal of the American College of Cardiology (2022)
Intramuscular depot medroxyprogesterone acetate accentuates bone loss associated with tenofovir disoproxil fumarate-containing antiretroviral therapy initiation in young women living with HIV (the BONE: CARE study): a prospective cohort study in Uganda
Authors: Flavia Kiweewa Matovu, Noah Kiwanuka, Martin Nabwana, Delia Scholes, Philippa Musoke, Mary Glenn Fowler, Mags E Beksinska, John M Pettifor, Todd T Brown, Flavia Matovu Kiweewa, Clemensia Nakabiito, Faith Nawagi, Betty Kamira, Esther Isingel, Stephen Bule, Violet Kukundakwe, Andrew Kateregga, Mary (Maria) Musisi, Paula Mubiru Namayanja, Dorothy Mirembe, Mary Speciosa Mbabali, Sarah Mulebeke, Joselyne Nabisere, Joyce Nakakande, Nicholas Matovu, Dorah Nakaye, Joshua Wynne, Faith Mulumba, Restituta Mukasa, Masitula Ssewanyana, Hadijah Kalule Nabunya, Florence Asiimwe Biira, Erinah Kyomukama, Suzan Nampiira, Aisha Zalwago, Margaret l Namuganga, Deborah Mwebaza, Prossy Ethel Namuli, Caroline Tulina, Florence Sempa Kikonyogo, Regina Bukenya Nabatanzi, Rosemary Muwawu, Jane Nsubuga Musisi, Margaret Nakato Saava, Mary Mukasa Kagwa Najjemba, Winfred Kaahwa, Rose Namwanje Mukalazi, Miriam Magomu Takhuli, Osman Sawsan, Margaret Mugenyi, Mary Agnes Mugagga, Francis Sserugo, Agnes Namuddu, Doreen Kemigisha, Justine Nakyeyune, Caroline Kawuma Nassozi, Juliet Asello, Zaam Zinda Nakawungu, Olivia Higiro Kaboggoza, Sarah Babirye Ssebabi, Bertha Birungi, Ruth Lutabi Ssentogo, Michael Charles Mubiru, Winnie Nansamba, Stella Nalusiba Kalungi, Luke Erismus Bukenya, Prossy Asiimwe, James Amos Bazira, Sulaiman Katongole, Martin Nabwana, Wenceslaus Twinomujuni, Susan Nakacwa, Joanita Nankya Baddokwaya, Alice Margaret Elwana, Juliet Nanyonjo, Susan Adikini, Justine Nalwoga, Godfrey Rwanzogyera, Fabian Okello, Daniel Kabenge Kiiza, Emmanuel Mayanja, Francis Katongole, Max Kiwewa, Francis Onen, Joseph Mutebo, Dick Mukasa, Joshua Tamale, Ismael Kibirige, Martin Nabwana
Journal: The Lancet Global Health (2022)

Tenofovir disoproxil fumarate (TDF) and intramuscular depot medroxyprogesterone acetate (DMPA-IM) are independently associated with reduced bone mineral density (BMD). We aimed to assess the combined effects of DMPA-IM use and TDF initiation on BMD in young adult women living with HIV over two years, compared with age-matched people without HIV.
Socioeconomic Inequalities in Elective and Nonelective Hospitalizations in Older Men
Authors: Peiyao Xu, Fiona M. Blyth, Vasi Naganathan, Robert G. Cumming, David J. Handelsman, Markus J. Seibel, David G. Le Couteur, Louise M. Waite, Saman Khalatbari-Soltani
Journal: JAMA Network Open (2022)

<h3>Importance</h3> Among older adults, there is limited and inconsistent evidence on the association between socioeconomic position (SEP) and elective and nonelective hospitalization. <h3>Objective</h3> To evaluate the association between SEP and all-cause and cause-specific elective and nonelective hospitalization and hospital length of stay among older men. <h3>Design, Setting, and Participants</h3> This population-based, prospective cohort study used data from the Concord Health and Aging in Men Project (CHAMP). CHAMP recruited 1705 men aged 70 years or older between January 28, 2005, and June 4, 2007, in Sydney, Australia. Data were analyzed from February 1 to September 30, 2021. <h3>Exposures</h3> Indicators of SEP, including education (university degree certificate, diploma or no postschool qualifications), occupation (professionals and managers; small employers and self-employed; or lower clerical, service, sales workers, skilled, and unskilled workers), and source of income (other sources of income than government pension, reliance on government pensions and other sources of income, or reliant solely on a government pension), and a cumulative SEP score (tertiles) as SEP indicators; 3-level variables present high, intermediate, and low SEP. <h3>Main Outcomes and Measures</h3> All-cause and cause-specific elective and nonelective hospitalizations, number of hospitalizations, and length of stay were the study outcomes, ascertained through data linkage. Associations were quantified using competing-risks survival regression and negative binomial regression. <h3>Results</h3> A total of 1566 men (mean [SD] age, 76.8 [5.4] years) were included. During a mean (SD) 9.07 (3.53) years of follow-up, 1067 men had at least 1 elective hospitalization, and 1255 men had at least 1 nonelective hospitalization. No associations were found between SEP and elective hospitalizations. Being in the lowest tertile for educational level (subhazard ratio [SHR], 1.32; 95% CI, 1.11-1.58), occupational position (SHR, 1.30; 95% CI, 1.12-1.50), sources of income (SHR, 1.33; 95% CI, 1.17-1.52), and cumulative SEP tertile groups (SHR, 1.45; 95% CI, 1.24-1.68) were all associated with having at least 1 nonelective hospitalization compared with those in the highest tertiles. Significant associations were found between being in the lowest SEP groups and increased numbers and longer length of stay of nonelective hospitalizations. <h3>Conclusions and Relevance</h3> In this prospective cohort study, low SEP was inversely associated with nonelective hospitalizations but not elective hospitalization in older men in Australia. These findings point to the existence of socioeconomic inequalities in health care use, indicative of a need to take action to reduce these inequalities.
Heart Failure, Precision Medicine, and Incremental Equity
Authors: Melvin R. Echols, Herman Taylor
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TCTAP A-055 Association of Left Atrial Volume Index With N-Terminal Pro-B-Type Natriuretic Peptide Level in Heart Failure Patients With Preserved Ejection Fraction
Authors: Shamim Chowdhury, Gobinda Kanti Paul, Mirza Md Nazrul Islam, Noor E. Jabeen, Mahmood Hasan Khan, Shiblee Sadeque Shakil
Journal: Journal of the American College of Cardiology (2022)
Aligning Incentives for Improving Diagnostic Excellence
Authors: Bob Kocher, Ezekiel J. Emanuel
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs (SPYRAL HTN-ON MED): a randomised, sham-controlled trial
Authors: Felix Mahfoud, David E Kandzari, Kazuomi Kario, Raymond R Townsend, Michael A Weber, Roland E Schmieder, Konstantinos Tsioufis, Stuart Pocock, Kyriakos Dimitriadis, James W Choi, Cara East, Richard D'Souza, Andrew S P Sharp, Sebastian Ewen, Antony Walton, Ingrid Hopper, Sandeep Brar, Pamela McKenna, Martin Fahy, Michael Böhm
Journal: The Lancet (2022)
Reactive oxygen species-activated self-amplifying prodrug nanoagent for tumor-specific Cu-chelate chemotherapy and cascaded photodynamic therapy
Authors: Jie Chen, Xiaomin Tan, Yanjuan Huang, Congjun Xu, Zishan Zeng, Ting Shan, Zilin Guan, Xiaoyu Xu, Zeqian Huang, Chunshun Zhao
Journal: Biomaterials (2022)
Associations of Parental Cancer With School Absenteeism, Medical Care Unaffordability, Health Care Use, and Mental Health Among Children
Authors: Zhiyuan Zheng, Jingxuan Zhao, Leticia Nogueira, Xuesong Han, Qinjin Fan, K. Robin Yabroff
Journal: JAMA Pediatrics (2022)

A cancer diagnosis can adversely affect other members of the family, including children. However, little is known about the extent to which history of parental cancer affects children's health.