tbuckley/cabot-search huggingface dataset:
Conserved and unique transcriptional features of pharyngeal arches in the skate (<i>Leucoraja erinacea</i>) and evolution of the jaw
Authors: Christine Hirschberger, Victoria A Sleight, Katharine E Criswell, Stephen J Clark, J Andrew Gillis
Journal: Molecular Biology and Evolution (2021)

Abstract The origin of the jaw is a long-standing problem in vertebrate evolutionary biology. Classical hypotheses of serial homology propose that the upper and lower jaw evolved through modifications of dorsal and ventral gill arch skeletal elements, respectively. If the jaw and gill arches are derived members of a primitive branchial series, we predict that they would share common developmental patterning mechanisms. Using candidate and RNAseq/differential gene expression analyses, we find broad conservation of dorsoventral (DV) patterning mechanisms within the developing mandibular, hyoid, and gill arches of a cartilaginous fish, the skate (Leucoraja erinacea). Shared features include expression of genes encoding members of the ventralizing BMP and endothelin signaling pathways and their effectors, the joint markers nkx3.2 and gdf5 and prochondrogenic transcription factor barx1, and the dorsal territory marker pou3f3. Additionally, we find that mesenchymal expression of eya1/six1 is an ancestral feature of the mandibular arch of jawed vertebrates, whereas differences in notch signaling distinguish the mandibular and gill arches in skate. Comparative transcriptomic analyses of mandibular and gill arch tissues reveal additional genes differentially expressed along the DV axis of the pharyngeal arches, including scamp5 as a novel marker of the dorsal mandibular arch, as well as distinct transcriptional features of mandibular and gill arch muscle progenitors and developing gill buds. Taken together, our findings reveal conserved patterning mechanisms in the pharyngeal arches of jawed vertebrates, consistent with serial homology of their skeletal derivatives, as well as unique transcriptional features that may underpin distinct jaw and gill arch morphologies.
Initiatives to Reduce Cesarean Delivery Rates for Low-risk First Births
Authors: David B. Nelson, Catherine Y. Spong
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SARS‐CoV‐2 infection in patients with atopic dermatitis: a cross‐sectional study
Authors: C. Nguyen, K. Yale, F. Casale, A. Ghigi, K. Zheng, J.I. Silverberg, N.A. Mesinkovska
Journal: British Journal of Dermatology (2021)

DEAR EDITOR, SARS-CoV-2 disproportionately impacts certain populations with inflammatory conditions that have an elevated risk of respiratory comorbidities. [1]2][3] Additionally, atopic dermatitis (AD) is associated with other atopic diseases, such as allergic rhinitis and asthma, which increase the risk of respiratory infections and predispose patients to neuropsychiatric disorders. 4 There are limited studies evaluating the role of systemic medications in risk of infection.However, recent studies postulated that systemic immunomodulatory and biologic treatments may protect patients from worsening SARS-CoV-2 outcomes. 5,6 In this study, we aimed to compare rates of SARS-CoV-2 infection, hospitalization and mortality among patients with or without AD in a California-based population.A retrospective cross-sectional study was conducted using the University of California COVID Research Data Set (UC CORDS), a Health Insurance Portability and Accountability Act secure medical records dataset for patients tested for SARS-CoV-2 across University of California medical centres. 7 Information regarding SARS-CoV-2 testing, patient demographics, hospitalization and mortality (from all causes, at any time after the positive test) was collected from 1 March 2020 to 8 October 2020.Patients with AD were diagnosed with 'atopic dermatitis' (International Classification of Diseases 10th Revision code L20Á9), 'acute dermatitis' (L30Á9), 'atopic neurodermatitis' (L20Á81), 'nummular eczema' (L30Á0) or 'flexural eczema' (L20Á82) by a dermatologist or primary care provider.Specific systemic treatment subgroups were identified (prednisone, methotrexate, ciclosporin or dupilumab) for at least 30 days prior to SARS-CoV-2 testing.Fisher exact and v 2 -tests were used for statistical analysis.In total 269 299 patients were tested within the UC CORDS, with a 3Á64% positive test rate (n = 9808, average age 42 years) (Table 1).Of these, 5387 patients with AD were tested for SARS-CoV-2 and had a 2Á95% (n = 159, average age 34 years) infection rate, which was lower than in those without AD (3Á66%, n = 9649, average age 42 years) (P = 0Á0063).This observation was significant in women with AD compared with those without (2Á7% vs. 3Á46%, P = 0Á022), but was not significant in men (3Á3% vs. 3Á89%, P = 0Á14).There were similar proportions of COVID-19-positive men with and without AD (49% vs. 47%, P = 0Á70).
INTRAOPERATIVE INDUCIBILITY OF ATRIAL FIBRILLATION IMPROVES RISK STRATIFICATION AND REDUCES POST-OPERATIVE ATRIAL FIBRILLATION
Authors: Terrence Pong, Kevin Cyr, Cody Carlton, John Niesen, Joy Aparicio-Valenzuela, Michael Fischbein, Y. Woo, Jack Boyd, Anson Lee
Journal: Journal of the American College of Cardiology (2021)
MITRAL VALVE DYSFUNCTION IN PATIENTS WITH PAPILLARY MUSCLE INVOLVEMENT DURING PREMATURE VENTRICULAR COMPLEX /VENTRICULAR TACHYCARDIA ABLATION
Authors: Dario Manley-Casco, Stephanie Crass, Momena Sohail, Komal Imtiaz, Dixy Rajkumar, Michael Battaglia, Jihn Han, Bipin Ravindran, Radmira Greenstein, Edwin Zishiri, Timothy Shinn, Shrinivas Hebsur
Journal: Journal of the American College of Cardiology (2021)
WHOLE EXOME SEQUENCING OF THREE PATIENTS WITH BRUGADA SYNDROME IN THE MIDDLE EAST- NOVEL VARIANTS IN KNOWN GENES IN RELATION TO A RANGE OF PHENOTYPES
Authors: Marwan Refaat, Athar Khalil, Farah Abdulhai, Joseph Elias, Mohammad Sabra, Jad Ballout, Patrick Zakka, Khalid Al Muti, Maurice Khoury, Bernard Abi-Saleh, Georges Nemer
Journal: Journal of the American College of Cardiology (2021)
<i>Notes from the Field:</i> An Outbreak of <i>Escherichia coli</i> O157:H7 Infections Linked to Romaine Lettuce Exposure — United States, 2019
Authors: Connor Hoff, Jeffrey Higa, Kane Patel, Ellen Gee, Allison Wellman, Jeff Vidanes, April Holland, Varvara Kozyreva, Jonathan Zhu, Mia Mattioli, Alexis Roundtree, Kenai McFadden, Laura Whitlock, Matthew Wise, Laura Gieraltowski, Colin Schwensohn
Journal: MMWR Morbidity and Mortality Weekly Report (2021)
ニコランジル経静脈前投与によるno/slow reflowの予防効果
Authors: 藤本良久, 河合勇介, 久松研一, 宗政充, 宮地克維, 徳永尚登, 赤木達, 旦一宏, 池田悦子, 永井正浩, 川合晴朗, 松原広己, 三河内弘
Journal: Circulation (2006)
OSBORNE WAVE IN ECG AS A PREDICTOR OF HOSPITAL MORTALITY IN COVID-19 ASSOCIATED PNEUMONIA
Authors: Naufal Zagidullin, Timur Musin, Zilya Bagmanova, Anton Tyurin, Damir Gareev, Halima Talipova, Paruir Davtyan, Ruslan Gumerov, Ruslan Garaev, Diana Gareeva, Dinar Enikeev, Irina Lackman, Valentin Pavlov
Journal: Journal of the American College of Cardiology (2021)
SEX-BASED DIFFERENCES IN CLINICAL OUTCOMES AFTER PERCUTANEOUS CORONARY INTERVENTION: INSIGHTS FROM THE TAILOR-PCI TRIAL
Authors: Mina Madan, J. Abbott, Ryan Lennon, Derek So, Andrea MacDougall, Mary Ann McLaughlin, Vishakantha Murthy, Jacqueline Saw, Charanjit Rihal, Michael Farkouh, Naveen Pereira, Shaun Goodman
Journal: Journal of the American College of Cardiology (2021)
REGIONAL VARIATION IN HOSPITAL OUTCOMES AMONG PATIENTS ADMITTED FOR MASSIVE PULMONARY EMBOLISM IN THE UNITED STATES BASED ON THE NATIONAL INPATIENT SAMPLE DATABASE
Authors: Sepideh Darbandi, Oluwole Adegbala, Yusra Shafqat, Fayez Siddiqui
Journal: Journal of the American College of Cardiology (2021)
WITHDRAWN: Glutaminolysis-induced mTORC1 activation drives non-alcoholic steatohepatitis progression
Authors: Noemí Cabré, Fedra Luciano-Mateo, Douglas J. Chapski, Gerard Baiges-Gaya, Salvador Fernández-Arroyo, Anna Hernández-Aguilera, Helena Castañé, Elisabet Rodríguez-Tomàs, Marta París, Fàtima Sabench, Daniel Del Castillo, Josep M. del Bas, Mercedes Tomé, Clément Bodineau, Alejandro Sola-García, José López-Miranda, Alejandro Martín-Montalvo, Raúl V. Durán, Thomas M. Vondriska, Manuel Rosa-Garrido, Jordi Camps, Javier A. Menéndez, Jorge Joven
Journal: Journal of Hepatology (2021)

A holistic insight on the relationship between obesity and metabolic dysfunction-associated fatty liver disease is an unmet clinical need. Omics investigations can be used to investigate the multifaceted role of altered mitochondrial pathways to promote nonalcoholic steatohepatitis, a major risk factor for liver disease-associated death. There are no specific treatments but remission via surgery might offer an opportunity to examine the signaling processes that govern the complex spectrum of chronic liver diseases observed in extreme obesity. We aim to assess the emerging relationship between metabolism, methylation and liver disease.
SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Authors: Joseph H. Choe, Payal B. Watchmaker, Milos S. Simic, Ryan D. Gilbert, Aileen W. Li, Nira A. Krasnow, Kira M. Downey, Wei Yu, Diego A. Carrera, Anna Celli, Juhyun Cho, Jessica D. Briones, Jason M. Duecker, Yitzhar E. Goretsky, Ruth Dannenfelser, Lia Cardarelli, Olga Troyanskaya, Sachdev S. Sidhu, Kole T. Roybal, Hideho Okada, Wendell A. Lim
Journal: Science Translational Medicine (2021)

Treatment of solid cancers with chimeric antigen receptor (CAR) T cells is plagued by the lack of ideal target antigens that are both absolutely tumor specific and homogeneously expressed. We show that multi-antigen prime-and-kill recognition circuits provide flexibility and precision to overcome these challenges in the context of glioblastoma. A synNotch receptor that recognizes a specific priming antigen, such as the heterogeneous but tumor-specific glioblastoma neoantigen epidermal growth factor receptor splice variant III (EGFRvIII) or the central nervous system (CNS) tissue-specific antigen myelin oligodendrocyte glycoprotein (MOG), can be used to locally induce expression of a CAR. This enables thorough but controlled tumor cell killing by targeting antigens that are homogeneous but not absolutely tumor specific. Moreover, synNotch-regulated CAR expression averts tonic signaling and exhaustion, maintaining a higher fraction of the T cells in a naïve/stem cell memory state. In immunodeficient mice bearing intracerebral patient-derived xenografts (PDXs) with heterogeneous expression of EGFRvIII, a single intravenous infusion of EGFRvIII synNotch-CAR T cells demonstrated higher antitumor efficacy and T cell durability than conventional constitutively expressed CAR T cells, without off-tumor killing. T cells transduced with a synNotch-CAR circuit primed by the CNS-specific antigen MOG also exhibited precise and potent control of intracerebral PDX without evidence of priming outside of the brain. In summary, by using circuits that integrate recognition of multiple imperfect but complementary antigens, we improve the specificity, completeness, and persistence of T cells directed against glioblastoma, providing a general recognition strategy applicable to other solid tumors.
Updated Recommendations from the Advisory Committee on Immunization Practices for Use of the Janssen (Johnson &amp; Johnson) COVID-19 Vaccine After Reports of Thrombosis with Thrombocytopenia Syndrome Among Vaccine Recipients — United States, April 2021
Authors: Jessica R. MacNeil, John R. Su, Karen R. Broder, Alice Y. Guh, Julia W. Gargano, Megan Wallace, Stephen C. Hadler, Heather M. Scobie, Amy E. Blain, Danielle Moulia, Matthew F. Daley, Veronica V. McNally, José R. Romero, H. Keipp Talbot, Grace M. Lee, Beth P. Bell, Sara E. Oliver
Journal: MMWR Morbidity and Mortality Weekly Report (2021)

The Advisory Committee on Immunization Practices concluded that the benefits of resuming Janssen COVID-19 vaccination among persons aged ≥18 years outweighed the risks and reaffirmed its interim recommendation under FDA's Emergency Use Authorization, which includes a new warning for rare clotting events among women aged 18–49 years.
Sentinel Lymph Node Concept in High–Risk Profile Endometrial Cancer—Reply
Authors: Sarah E. Ferguson, Maria C. Cusimano
Journal: JAMA Surgery (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Unsupervised learning predicts human perception and misperception of gloss
Authors: Katherine R. Storrs, Barton L. Anderson, Roland W. Fleming
Journal: Nature Human Behaviour (2021)

Abstract Reflectance, lighting and geometry combine in complex ways to create images. How do we disentangle these to perceive individual properties, such as surface glossiness? We suggest that brains disentangle properties by learning to model statistical structure in proximal images. To test this hypothesis, we trained unsupervised generative neural networks on renderings of glossy surfaces and compared their representations with human gloss judgements. The networks spontaneously cluster images according to distal properties such as reflectance and illumination, despite receiving no explicit information about these properties. Intriguingly, the resulting representations also predict the specific patterns of ‘successes’ and ‘errors’ in human perception. Linearly decoding specular reflectance from the model’s internal code predicts human gloss perception better than ground truth, supervised networks or control models, and it predicts, on an image-by-image basis, illusions of gloss perception caused by interactions between material, shape and lighting. Unsupervised learning may underlie many perceptual dimensions in vision and beyond.
NETWORK META-ANALYSIS OF REVASCULARIZATION STRATEGIES FOR PATIENTS WITH CORONARY ARTERY DISEASE AND REDUCED EJECTION FRACTION
Authors: Yujiro Yokoyama, Shinichi Fukuhara, Makoto Mori, Masahiko Noguchi, Hisato Takagi, Alexandros Briasoulis, Toshiki Kuno
Journal: Journal of the American College of Cardiology (2021)
FEMOROPOPLITEAL ARTERY BAIL-OUT STENTING: INSIGHTS FROM THE EXCELLENCE IN PERIPHERAL ARTERY DISEASE (XLPAD) REGISTRY
Authors: Kunal Patel, Yulun Liu, Shirling Tsai, Bala Ramanan, Tayo Addo, Mohamed Amer Alaiti, Subhash Banerjee
Journal: Journal of the American College of Cardiology (2021)
LONG-TERM ADVERSE OUTCOMES IN PATIENTS WITH PERCUTANEOUS CORONARY INTERVENTION (PCI) IN BYPASS GRAFTS. A CAUSE FOR CONCERN
Authors: Wan Kim, Gregory Hirsch, Catherine Kells, Ata-Ur-Rehman Quraishi, Helen Bishop, Bakhtiar Kidwai, Lawrence Title, Hussein Beydoun, Osama ElKhateeb
Journal: Journal of the American College of Cardiology (2021)
DETECTION OF HYPERTROPHIC CARDIOMYOPATHY BY ARTIFICIAL INTELLIGENCE-ENABLED ELECTROCARDIOGRAPHY IN CHILDREN AND ADOLESCENTS
Authors: Konstantinos Siontis, Kan Liu, J. Martijn Bos, Zachi Itzhak Attia, Adelaide Arruda-Olson, Nasibeh Z. Farahani, Paul Friedman, Peter Noseworthy, Michael Ackerman
Journal: Journal of the American College of Cardiology (2021)
RECURRENT PERICARDITIS IN A YOUNG FEMALE POST PERICARDIECTOMY WITH INABILITY TO WEAN OFF ANAKINRA
Authors: Hassan Mehmood Lak, Chris Anthony, Muhammad Furqan, Mohamed Gad, Sanchit Chawla, Beni Verma, Farah Yasmin, Ahmad Mustafa, Allan Klein
Journal: Journal of the American College of Cardiology (2021)
Beyond the First Dose — Covid-19 Vaccine Follow-through and Continued Protective Measures
Authors: Jillian L. Goldfarb, Sarah Kreps, John S. Brownstein, Douglas L. Kriner
Journal: New England Journal of Medicine (2021)

Beyond the First Dose According to a recent survey, many Americans remain confused about the timing of protection from Covid vaccines and the necessity of a second dose. A large proportion of vacci...
CO-EXISTING PROTEIN ENERGY MALNUTRITION IS ASSOCIATED WITH INCREASED MORTALITY IN PATIENTS ADMITTED FOR HEART TRANSPLANT: ANALYSIS OF NATIONAL INPATIENT SAMPLE
Authors: Muhammad Usman Almani, Muhammad Usman, Cyra-Yoonsun Kang, Emmanuel Akuna, Iriagbonse Rotimi Asemota, Mahmoud Elbermawy, Raquel Soon-Shiong, Smriti Khanal, Dimeji Williams, Bharosa Sharma, Muhammad Talha Ayub
Journal: Journal of the American College of Cardiology (2021)
MYOPATHY IN SEVERE ASTHMA
Authors: Ja Douglass, Dv Tuxen, M Horne, Cd Scheinkestel, M Weinmann, D Czarny, G Bowes
Journal: American Journal of Respiratory and Critical Care Medicine (1992)

Myopathy complicating the therapy of severe asthma has been recently described in several case reports. Twenty-five consecutive patients admitted to the intensive care unit (ICU) at this hospital for mechanical ventilation for severe asthma were studied for the incidence of creatine kinase (CK) enzyme rise and for the development of clinical myopathy. Pharmacologic therapy was standardized, every patient receiving corticosteroids and aminophylline intravenously and salbutamol both nebulized and intravenously. Twenty-two patients received muscle relaxant therapy with vecuronium. In 19 of 25 (76%) of patients there was elevation of CK levels to a median of 1,575 U/L (range, 66 to 7,430) occurring 3.6 +/- 1.5 days after admission. In nine patients there was clinically detectable myopathy. The presence of either myopathy or CK enzyme rise was associated with a significant prolongation of ventilation time. Arterial blood gas measurements on admission to the ICU revealed a pH (mean +/- SD) of 7.07 +/- 0.21, a PaCO2 of 87.2 +/- 32.7, and a PaO2 (with a high FIO2) of 129 +/- 97 mm Hg; however, no correlation was found between the severity of initial metabolic disturbance and the subsequent development of myopathy. There was no association between the type of corticosteroid administered and the subsequent development of myopathy. Patients with myopathy had received a significantly higher total dose of vecuronium when compared with those who did not develop myopathy (p < 0.001, Kruskal Wallis test). We have therefore found a surprisingly high incidence of CK enzyme rise and myopathy in this group of mechanically ventilated patients with severe asthma.(ABSTRACT TRUNCATED AT 250 WORDS)
Enteric viruses evoke broad host immune responses resembling those elicited by the bacterial microbiome
Authors: Simone Dallari, Thomas Heaney, Adriana Rosas-Villegas, Jessica A. Neil, Serre-Yu Wong, Judy J. Brown, Kelly Urbanek, Christin Herrmann, Daniel P. Depledge, Terence S. Dermody, Ken Cadwell
Journal: Cell Host & Microbe (2021)
Nampt Potentiates Antioxidant Defense in Diabetic Cardiomyopathy
Authors: Shin-ichi Oka, Jaemin Byun, Chun-yang Huang, Nobushige Imai, Guersom Ralda, Peiyong Zhai, Xiaoyong Xu, Sanchita Kashyap, Junco S. Warren, John Alan Maschek, Trevor S. Tippetts, Mingming Tong, Sundararajan Venkatesh, Yoshiyuki Ikeda, Wataru Mizushima, Toshihide Kashihara, Junichi Sadoshima
Journal: Circulation Research (2021)

[Figure: see text].
Mental health support through primary care during and after covid-19
Authors: Faraz Mughal, Muhammad Z Hossain, Angela Brady, Judy Samuel, Carolyn A Chew-Graham
Journal: BMJ (2021)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Mental health support through primary care during and after covid-19 Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
ADVERSE PROGNOSTIC PREDICTORS AMONG PATIENTS PRESENTING WITH OUT-OF-HOSPITAL CARDIAC ARREST AND A SHOCKABLE RHYTHM
Authors: Wayne Zheng, Samer Noaman, Riley Batchelor, Laura Hanson, Jason Bloom, David Kaye, Stephen Duffy, Tony Walton, Vincent Pellegrino, Yang Yang, Craig French, Nicholas Cox, Dion Stub, William Chan
Journal: Journal of the American College of Cardiology (2021)
Epirubicin and Cyclophosphamide–induced Acute Fibrinous and Organizing Pneumonia
Authors: Taeka Naraoka, Toshiyuki Sumi, Yoshiko Keira, Hisashi Nakata, Hirofumi Chiba
Journal: American Journal of Respiratory and Critical Care Medicine (2021)

"Epirubicin and Cyclophosphamide–induced Acute Fibrinous and Organizing Pneumonia." American Journal of Respiratory and Critical Care Medicine, 204(8), pp. e92–e93