tbuckley/cabot-search huggingface dataset:
Fall Influenza A(H3N2) Outbreak at a Midwestern University
Authors: Bridget M. Kuehn
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Positive predictive value of mpmri in men under active surveillance: Can the biopsy history influence radiological assessment?
Authors: L. Nocera, A. Stabile, R. Leni, G. Gandaglia, N. Fossati, F. Pellegrino, G. Sorce, E. Mazzone, C. Bravi, G. Rosiello, A. Martini, A. Pellegrino, D. Robesti, D. Cannoletta, S. Scuderi, F.M. Barletta, F. De Cobelli, U. Pinar, T. Seisen, M. Roupret, J. Karnes, S. Boorjian, F. Montorsi, A. Briganti
Journal: European Urology (2021)
Three-year outcomes after Aquablation compared to TURP: Efficacy and ejaculatory improvements sustained
Authors: N. Barber, P. Gilling, M. Bidair, P. Anderson, M. Sutton, T. Aho, E. Kramolowsky, A. Thomas, B. Cowan, R.P. Kaufman, A. Trainer, A. Arther, G. Gopal Badlani, M. Plante, M. Desai, L. Doumanian, A.E. Te, M. Mark Deguenther, C. Claus Roehrborn
Journal: European Urology (2021)
Screening for Atrial Fibrillation—New Devices, Same Challenges
Authors: John Mandrola, Andrew Foy
Journal: JAMA Internal Medicine (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Antisense oligonucleotide silencing of FUS expression as a therapeutic approach in amyotrophic lateral sclerosis
Authors: Vladislav A. Korobeynikov, Alexander K. Lyashchenko, Beatriz Blanco-Redondo, Paymaan Jafar-Nejad, Neil A. Shneider
Journal: Nature Medicine (2022)

Abstract Fused in sarcoma (FUS) is an RNA-binding protein that is genetically and pathologically associated with rare and aggressive forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). To explore the mechanisms by which mutant FUS causes neurodegeneration in ALS-FTD, we generated a series of FUS knock-in mouse lines that express the equivalent of ALS-associated mutant FUSP525L and FUSΔEX14 protein. In FUS mutant mice, we show progressive, age-dependent motor neuron loss as a consequence of a dose-dependent gain of toxic function, associated with the insolubility of FUS and related RNA-binding proteins. In this disease-relevant mouse model of ALS-FUS, we show that ION363, a non-allele-specific FUS antisense oligonucleotide, efficiently silences Fus and reduces postnatal levels of FUS protein in the brain and spinal cord, delaying motor neuron degeneration. In a patient with ALS with a FUSP525L mutation, we provide preliminary evidence that repeated intrathecal infusions of ION363 lower wild-type and mutant FUS levels in the central nervous system, resulting in a marked reduction in the burden of FUS aggregates that are a pathological hallmark of disease. In mouse genetic and human clinical studies, we provide evidence in support of FUS silencing as a therapeutic strategy in FUS-dependent ALS and FTD.
Tissue-Resident Immune Cells in Humans
Authors: Joshua I. Gray, Donna L. Farber
Journal: Annual Review of Immunology (2022)

Tissue-resident immune cells span both myeloid and lymphoid cell lineages, have been found in multiple human tissues, and play integral roles at all stages of the immune response, from maintaining homeostasis to responding to infectious challenges to resolution of inflammation to tissue repair. In humans, studying immune cells and responses in tissues is challenging, although recent advances in sampling and high-dimensional profiling have provided new insights into the ontogeny, maintenance, and functional role of tissue-resident immune cells. Each tissue contains a specific complement of resident immune cells. Moreover, resident immune cells for each lineage share core properties, along with tissue-specific adaptations. Here we propose a five-point checklist for defining resident immune cell types in humans and describe the currently known features of resident immune cells, their mechanisms of development, and their putative functional roles within various human organs. We also consider these aspects of resident immune cells in the context of future studies and therapeutics.
Open chromatin interaction maps reveal functional regulatory elements and chromatin architecture variations during wheat evolution
Authors: Jingya Yuan, Haojie Sun, Yijin Wang, Lulu Li, Shiting Chen, Wu Jiao, Guanghong Jia, Longfei Wang, Junrong Mao, Zhongfu Ni, Xiue Wang, Qingxin Song
Journal: Genome biology (2022)

Bread wheat (Triticum aestivum) is an allohexaploid that is generated by two subsequent allopolyploidization events. The large genome size (16 Gb) and polyploid complexity impede our understanding of how regulatory elements and their interactions shape chromatin structure and gene expression in wheat. The open chromatin enrichment and network Hi-C (OCEAN-C) is a powerful antibody-independent method to detect chromatin interactions between open chromatin regions throughout the genome.
Withdrawal notice to: &lt;Describing the unvaccinated as the main driver of the current COVID-19 situation in Germany should not be based on analyzing pre-pandemic patterns of contacts&gt; &lt;[The Lancet Regional Health Europe 12 (2022) 100290]&gt;
Authors: Günter Kampf
Journal: The Lancet Regional Health - Europe (2022)

[This retracts the article DOI: 10.1016/j.lanepe.2021.100290.].
P1.12-006 The Efficacy of Electrocautery Using Wire Snare as the Primary Ablation Modality for Malignant and Benign Airway Obstruction
Authors: M. Harada, T. Hishima, T. Yamamichi, A. Asakawa, M. Okui, H. Horio
Journal: Journal of Thoracic Oncology (2017)
Correction to: Bleeding and thrombotic events in adults supported with venovenous extracorporeal membrane oxygenation: an ELSO registry analysis
Authors: Jose I. Nunez, Andre F. Gosling, Brian O’Gara, Kevin F. Kennedy, Peter Rycus, Darryl Abrams, Daniel Brodie, Shahzad Shaefi, A. Reshad Garan, E. Wilson Grandin
Journal: Intensive Care Medicine (2022)
Ethical commitments, principles, and practices guiding intracranial neuroscientific research in humans
Authors: Ashley Feinsinger, Nader Pouratian, Hamasa Ebadi, Ralph Adolphs, Richard Andersen, Michael S. Beauchamp, Edward F. Chang, Nathan E. Crone, Jennifer L. Collinger, Itzhak Fried, Adam Mamelak, Mark Richardson, Ueli Rutishauser, Sameer A. Sheth, Nanthia Suthana, Nitin Tandon, Daniel Yoshor
Journal: Neuron (2022)
1069P A multicenter phase II study of nivolumab combined with ipilimumab in patients with pediatric solid tumours in adulthood (GETHI021)
Authors: X. Mielgo Rubio, R. Diaz-Beveritge, J.M. Sepulveda Sanchez, E. Pineda, M.Á. Vaz Salgado, M.J. Lecumberri, C. Valverde, R. Lopez Castro, C. López, J.A. Virizuela Echaburu, N. Rodriguez Salas, R. de las Penas Bataller, R. Lopez Lopez, J. Medina Rodriguez, C. Rodriguez-Antona, P. Berraondo, J.F. Rodriguez-Moreno, A. Hurtado Nuño, E. Sevillano, J. Garcia-Donas
Journal: Annals of Oncology (2020)
TRENDS IN THE USE OF HIGH-INTENSITY STATIN THERAPY AFTER MYOCARDIAL INFARCTION, 2011-2014
Authors: Robert S. Rosenson, Michael Farkouh, Matthew Mefford, Vera Bittner, Todd Brown, Ben Taylor, Keri Monda, Hong Zhao, Yu Ling Dai, Paul Muntner
Journal: Journal of the American College of Cardiology (2017)
Oral ixazomib-dexamethasone vs oral pomalidomide-dexamethasone for lenalidomide-refractory, proteasome inhibitor-exposed multiple myeloma: a randomized Phase﻿ 2 trial
Authors: Meletios A. Dimopoulos, Fredrik Schjesvold, Vadim Doronin, Olga Vinogradova, Hang Quach, Xavier Leleu, Yolanda Gonzalez Montes, Karthik Ramasamy, Alessandra Pompa, Mark-David Levin, Cindy Lee, Ulf Henrik Mellqvist, Roland Fenk, Hélène Demarquette, Hamdi Sati, Alexander Vorog, Richard Labotka, Jichang Du, Mohamed Darif, Shaji Kumar
Journal: Blood Cancer Journal (2022)

Multiple myeloma (MM) patients typically receive several lines of combination therapy and first-line treatment commonly includes lenalidomide. As patients age, they become less tolerant to treatment, requiring convenient/tolerable/lenalidomide-free options. Carfilzomib and/or bortezomib-exposed/intolerant, lenalidomide-refractory MM patients with ≥2 prior lines of therapy were randomized 3:2 to ixazomib-dexamethasone (ixa-dex) (n = 73) or pomalidomide-dexamethasone (pom-dex) (n = 49) until progression/toxicity. Median progression-free survival (mPFS) was 7.1 vs 4.8 months with ixa-dex vs pom-dex (HR 0.847, 95% CI 0.535-1.341, P = 0.477; median follow-up: 15.3 vs 17.3 months); there was no statistically significant difference between arms. In patients with 2 and ≥3 prior lines of therapy, respectively, mPFS was 11.0 vs 5.7 months (HR 1.083, 95% CI 0.547-2.144) and 5.7 vs 3.7 months (HR 0.686, 95% CI 0.368-1.279). Among ixa-dex vs pom-dex patients, 69% vs 81% had Grade ≥3 treatment-emergent adverse events (TEAEs), 51% vs 53% had serious TEAEs, 39% vs 36% had TEAEs leading to drug discontinuation, 44% vs 32% had TEAEs leading to dose reduction, and 13% vs 13% died on study. Quality of life was similar between arms and maintained during treatment. Ixa-dex represents an important lenalidomide-free, oral option for this heavily pretreated, lenalidomide-refractory, proteasome inhibitor-exposed population.Trial registration: ClinicalTrials.gov number, NCT03170882.
Ibrutinib–rituximab followed by R-HCVAD as frontline treatment for young patients (≤65 years) with mantle cell lymphoma (WINDOW-1): a single-arm, phase 2 trial
Authors: Michael L Wang, Preetesh Jain, Shuangtao Zhao, Hun Ju Lee, Loretta Nastoupil, Luis Fayad, Chi Young Ok, Rashmi Kanagal-Shamanna, Holly A Hill, Yixin Yao, Fredrick B Hagemeister, Jason R Westin, Nathan Fowler, Felipe Samaniego, Raphael Steiner, Ranjit Nair, Swaminathan P Iyer, Lucy Navsaria, Maria Badillo, Lei Feng, Huang Xuelin, Graciela M Nogueras Gonzalez, Guofan Xu, Nicolaus Wagner-Bartak, Selvi Thirumurthi, David Santos, Guilin Tang, Pei Lin, Sa A Wang, Jeff Jorgensen, C Cameron Yin, Shaoying Li, Keyur P Patel, Francisco Vega, L Jeffery Medeiros, Christopher R Flowers, Linghua Wang
Journal: The Lancet Oncology (2022)
Erratum to: Genus-wide characterization of bumblebee genomes provides insights into their evolution and variation in ecological and behavioral traits
Authors: Cheng Sun, Jiaxing Huang, Yun Wang, Xiaomeng Zhao, Long Su, Gregg W C Thomas, Mengya Zhao, Xingtan Zhang, Irwin Jungreis, Manolis Kellis, Saverio Vicario, Igor V Sharakhov, Semen M Bondarenko, Martin Hasselmann, Chang N Kim, Benedict Paten, Luca Penso-Dolfin, Li Wang, Yuxiao Chang, Qiang Gao, Ling Ma, Lina Ma, Zhang Zhang, Hongbo Zhang, Huahao Zhang, Livio Ruzzante, Hugh M Robertson, Yihui Zhu, Yanjie Liu, Huipeng Yang, Lele Ding, Quangui Wang, Dongna Ma, Weilin Xu, Cheng Liang, Michael W Itgen, Lauren Mee, Gang Cao, Ze Zhang, Ben M Sadd, Matthew W Hahn, Sarah Schaack, Seth M Barribeau, Paul H Williams, Robert M Waterhouse, Rachel Lockridge Mueller
Journal: Molecular Biology and Evolution (2021)
Marker-free surgical navigation of rod bending using a stereo neural network and augmented reality in spinal fusion
Authors: Marco von Atzigen, Florentin Liebmann, Armando Hoch, José Miguel Spirig, Mazda Farshad, Jess Snedeker, Philipp Fürnstahl
Journal: Medical Image Analysis (2022)

The instrumentation of spinal fusion surgeries includes pedicle screw placement and rod implantation. While several surgical navigation approaches have been proposed for pedicle screw placement, less attention has been devoted towards the guidance of patient-specific adaptation of the rod implant. We propose a marker-free and intuitive Augmented Reality (AR) approach to navigate the bending process required for rod implantation. A stereo neural network is trained from the stereo video streams of the Microsoft HoloLens in an end-to-end fashion to determine the location of corresponding pedicle screw heads. From the digitized screw head positions, the optimal rod shape is calculated, translated into a set of bending parameters, and used for guiding the surgeon with a novel navigation approach. In the AR-based navigation, the surgeon is guided step-by-step in the use of the surgical tools to achieve an optimal result. We have evaluated the performance of our method on human cadavers against two benchmark methods, namely conventional freehand bending and marker-based bending navigation in terms of bending time and rebending maneuvers. We achieved an average bending time of 231s with 0.6 rebending maneuvers per rod compared to 476s (3.5 rebendings) and 348s (1.1 rebendings) obtained by our freehand and marker-based benchmarks, respectively.
Humoral Response to 2-dose BNT162b2 mRNA COVID-19 Vaccination in Liver Transplant Recipients
Authors: Maria Guarino, Ilaria Esposito, Giuseppe Portella, Valentina Cossiga, Ilaria Loperto, Raffaella Tortora, Michele Cennamo, Mario Capasso, Daniela Terracciano, Alfonso Galeota Lanza, Sarah Di Somma, Francesco Paolo Picciotto, Filomena Morisco, Giuseppina Pontillo, Luca Pignata, Maria Rosaria Attanasio, Raffaele Lieto, Francesco Cutolo, Marianna Cuomo
Journal: Clinical Gastroenterology and Hepatology (2022)
Correction to: Prognostic value of global deep white matter DTI metrics for 1-year outcome prediction in ICU traumatic brain injury patients: an MRI-COMA and CENTER-TBI combined study
Authors: Louis Puybasset, Vincent Perlbarg, Jean Unrug, Didier Cassereau, Damien Galanaud, Grégory Torkomian, Valentine Battisti, Muriel Lefort, Lionel Velly, Vincent Degos, Guiseppe Citerio, Éléonore Bayen, Mélanie Pelegrini-Issac
Journal: Intensive Care Medicine (2022)
ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder
Authors: Yuze Yan, Miaomiao Tian, Meng Li, Gang Zhou, Qinan Chen, Mingrui Xu, Yi Hu, Wenhan Luo, Xiuxian Guo, Cheng Zhang, Hong Xie, Qing-Feng Wu, Wei Xiong, Shiguo Liu, Ji-Song Guan
Journal: Neuron (2022)
Detection of significant prostate cancer using target saturation in transperineal magnetic resonance imaging/transrectal ultrasonography–fusion biopsy: A prospective, randomized comparison to conventional target biopsy
Authors: Y. Saner, M. Wiesenfarth, S. Tschirdewahn, L. Püllen, D. Bonekamp, U. Krafft, C. Kesch, C. Darr, M. Forsting, L. Umutlu, B.A. Hadaschik, J.P. Radtke
Journal: European Urology (2021)
Re: Herjan J.T. Coelingh Bennink, Jean-Michel Foidart, Frans M.J. Debruyne. Treatment of Serious COVID-19 with Testosterone Suppression and High-dose Estrogen Therapy. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2021.06.024
Authors: Bexultan Kazybay, Yingqiu Xie
Journal: European Urology (2021)
Reply to Sungeun Kim, Jae Il Shin, and Jonathan Evan Shoag’s Letter to the Editor re: Luca F. Valle, Eric J. Lehrer, Daniela Markovic, et al. A Systematic Review and Meta-analysis of Local Salvage Therapies After Radiotherapy for Prostate Cancer (MASTER). Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.11.010
Authors: Luca F. Valle, Amar U. Kishan
Journal: European Urology (2021)
Screening for Atrial Fibrillation—Refining the Target
Authors: Matthew M. Kalscheur, Zachary D. Goldberger
Journal: JAMA Network Open (2022)

US Preventive Services Task Force; Karina W. Davidson, PhD, MASc; Michael J. Barry, MD; Carol M. Mangione, MD, MSPH; Michael Cabana, MD, MA, MPH; Aaron B. Caughey, MD, PhD; Esa M. Davis, MD, MPH; Katrina E. Donahue, MD, MPH; Chyke A. Doubeni, MD, MPH; John W. Epling Jr, MD, MSEd; Martha Kubik, PhD, RN; Li Li, MD, PhD, MPH; Gbenga Ogedegbe, MD, MPH; Lori Pbert, PhD; Michael Silverstein, MD, MPH; James Stevermer, MD, MSPH; Chien-Wen Tseng, MD, MPH, MSEE; John B. Wong, MD
Impact of Diabetes Duration on Functional and Clinical Status in Older Adults With Type 1 Diabetes
Authors: Medha Munshi, Christine Slyne, Atif Adam, Dai’Quann Davis, Amy Michals, Astrid Atakov-Castillo, Katie Weinger, Elena Toschi
Journal: Diabetes Care (2022)

OBJECTIVE Adults with type 1 diabetes (T1D) are aging successfully. The impact of diabetes duration on clinical and functional status as people age with T1D is not well known. RESEARCH DESIGN AND METHODS We performed a cross-sectional study of older adults (age ≥65 years) with T1D. RESULTS We evaluated 165 older adults, mean age 70 ± 10 years. After adjustment for age, sex, and A1C, longer duration of T1D, ≥50 years, was associated with a higher likelihood of depression (odds ratio [OR] 2.8; P = 0.008), hypoglycemia unawareness (OR 2.6; P = 0.01), lower scores on 6-Minute Walk Test (OR 0.99; P = 0.01) and the Physical Component Summary (PCS) of Short Form-36 (SF-36) (OR 0.96; P = 0.02), and greater daily medication use (OR 1.1; P = 0.004) compared with those with duration &amp;lt;50 years. CONCLUSIONS In older adults with T1D, duration of diabetes impacts clinical and functional status, independent of age and glycemic control, and should be considered in development of management strategies for safety and success.
Updated Phase II Study of Targeted Subcutaneous (SC) Bortezomib for Patients with Low- or Intermediate-1 (Int-1)-Risk Myelodysplastic Syndrome (MDS) with Evidence of NF-κb Activation
Authors: May Daher, Juliana Elisa Hidalgo Lopez, Jasleen K. Randhawa, Kausar Jabeen Jabbar, Naveen Pemmaraju, Gautam Borthakur, Tapan M. Kadia, Marina Konopleva, Hagop M. Kantarjian, Jorge E. Cortes, Katherine P. Hearn, Steven R. Reyes, Carlos E. Bueso-Ramos, Guillermo Garcia-Manero
Journal: Blood (2016)
Coagulome and the tumor microenvironment: an actionable interplay
Authors: Antoine Galmiche, Janusz Rak, Lubka T. Roumenina, Zuzana Saidak
Journal: Trends in cancer (2022)

Human tumors often trigger a hypercoagulable state that promotes hemostatic complications, including venous thromboembolism. The recent application of systems biology to the study of the coagulome highlighted its link to shaping the tumor microenvironment (TME), both within and outside of the vascular space. Addressing this link provides the opportunity to revisit the significance of biomarkers of hemostasis and assess the communication between vasculature and tumor parenchyma, an important topic considering the advent of immune checkpoint inhibitors and vascular normalization strategies. Understanding how the coagulome and TME influence each other offers exciting new prospects for predicting hemostatic complications and boosting the effectiveness of cancer treatment.
Clofarabine Plus Low-Dose Cytarabine for the Treatment of Patients with Higher-Risk Myelodysplastic Syndrome (MDS) Who Have Been Relapsing after, or Are Refractory to, Hypomethylating Agent (HMA) Therapy
Authors: Elias J. Jabbour, Hagop M. Kantarjian, Koji Sasaki, Tapan M. Kadia, Farhad Ravandi, Jorge E. Cortes, Joseph D Khoury, Keyur P. Patel, Carlos E. Bueso-Ramos, Naval G. Daver, Gautam Borthakur, Nitin Jain, Courtney D DiNardo, Marina Konopleva, Srdan Verstovsek, Naveen Pemmaraju, Zeev Estrov, Darla Miller, Rita Maduike, Stefan Faderl, Guillermo Garcia-Manero
Journal: Blood (2016)
The Best Bad News
Authors: N. Seth Trueger
Journal: JAMA Neurology (2022)

The Best Bad News "I'm sorry to have to tell you this," said the man on the phone, "but they found cancer.""That's the best news I've heard in a year," I replied.In a year that started with a historic pandemic full of tragedy and surreality, this moment was surreally cathartic.I began 2020 unsure what to make of coronavirus news, skeptical it would change much.Soon, we heard devastating stories from Italian hospitals.My world first changed mid-March 2020, my first emergency department (ED) shift flush with symptomatic patients, new protocols for "testing," and workarounds to deal with the lack of testing.We were in the first COVID-19 wave, reusing off-brand personal protective equipment, never quite overwhelmed but only because we tripled intensive care unit capacity and converted the entire hospital to a COVID-19 hospital.Like many, I didn't want this but was proud to confront the historic challenge.My biggest fear was bringing COVID-19 home to my family.My life has felt charmed.I grew up in an affluent suburb, and compartmentalizing work came easy; medical school and residency were tough but fulfilling challenges.As the days went by, I found myself with a wonderful wife and daughter and a career I enjoyed that rarely felt like work.Occasionally, I worried that the other shoe would drop-it could be COVID-19.My wife and daughter moved in with my wife's sister across town for the pandemic's first 2 months.Not quite isolated in the countryside like those World War II stories, but "safe" until we felt things quieted down enough.