tbuckley/cabot-search huggingface dataset:
Non-steroidal anti-inflammatory drugs, intravenous fluids, pancreatic stents, or their combinations for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a systematic review and network meta-analysis
Authors: Venkata S Akshintala, Christina J Sperna Weiland, Furqan A Bhullar, Ayesha Kamal, Kavin Kanthasamy, Albert Kuo, Cristian Tomasetti, Merve Gurakar, Joost P H Drenth, Dhiraj Yadav, B Joseph Elmunzer, D Nageshwar Reddy, Mahesh K Goenka, Rakesh Kochhar, Anthony N Kalloo, Mouen A Khashab, Erwin J M van Geenen, Vikesh K Singh
Journal: The Lancet. Gastroenterology & hepatology (2021)
Effectiveness of an mHealth system on access to eye health services in Kenya: a cluster-randomised controlled trial
Authors: Hillary Rono, Andrew Bastawrous, David Macleod, Ronald Mamboleo, Cosmas Bunywera, Emmanuel Wanjala, Stephen Gichuhi, Matthew J Burton
Journal: The Lancet Digital Health (2021)

BackgroundThere is limited access to eye health services in many low-income and middle-income populations. We aimed to assess the effectiveness in increasing service utilisation of the Peek Community Eye Health (Peek CEH) system, a smartphone-based referral system comprising decision support algorithms (Peek Community Screening app), SMS reminders, and real-time reporting.MethodsIn this cluster-randomised controlled trial of eye health in Kenya, community unit clusters were defined as one health centre and its catchment population. Clusters were randomly allocated (1:1) to receive Peek CEH and referral (intervention group) or standard care via periodic health centre-based outreach clinics and onward referral (control group). Individuals in the intervention group were assessed at home by screeners and those referred were asked to present for triage assessment in a central location. They received regular SMS reminders. In both groups, community sensitisation was done followed by a triage clinic at the cluster health centre 4 weeks after sensitisation. During triage, individuals in both groups were assessed and treated and, if necessary, referred to a specific hospital. Individuals in the intervention group received further SMS reminders. The primary outcome was the mean attendance rate (the number of people per 10 000 population) at triage of those with confirmed eye conditions, as assessed at 4 weeks after sensitisation in the intention-to-treat population. We estimated the intervention effect using a Student's t-test on cluster-level rates. This trial is registered with Pan African Clinical Trial Registry, number 201807329096632.FindingsBetween Nov 26, 2018, and June 7, 2019, of the 85 community units in Trans Nzoia County, Kenya, 49 were excluded. We randomly allocated 18 community units each to the intervention group (68 348 individuals) and the control group (60 243 individuals). 9387 individuals from the intervention group and 3070 from the control group attended triage assessment. The mean attendance rate at triage by individuals with eye problems was 1429 (92% CI 1228–1629) in the intervention group and 522 (418–625) in the control group (rate difference 906 per 10 000 [95% CI 689–1124; p<0·0001]).InterpretationThe Peek CEH system increased primary care attendance by people with eye problems compared with standard approaches, indicating the potential of this mobile health package to increase service uptake and guide appropriate task sharing.FundingThe Queen Elizabeth Diamond Jubilee Trust and Wellcome Trust.
Germline ERBB2 Variants Associate with Myeloproliferative Neoplasms
Authors: Evan M Braunstein, Donna Marie Williams, Igor Makhlin, Aparna Pallavajjala, Christopher D Gocke, Nara Sobreira, Kala Visvanathan, Linda Resar, Jerry L. Spivak, Alison R. Moliterno
Journal: Blood (2017)
喘息-慢性閉塞性肺疾患重複患者におけるニトロソ化ストレス【JST・京大機械翻訳】
Authors: Kyogoku Yorihiko, Sugiura Hisatoshi, Ichikawa Tomohiro, Numakura Tadahisa, Koarai Akira, Yamada Mitsuhiro, Fujino Naoya, Tojo Yutaka, Onodera Katsuhiro, Tanaka Rie, Sato Kei, Sano Hirohito, Yamanaka Shun, Itakura Koji, Mitsune Ayumi, Tamada Tsutomu, Akaike Takaaki, Ichinose Masakazu
Journal: Journal of Allergy and Clinical Immunology (2019)
When East Meets West, Understanding Is a 2-Way Street
Authors: DuyKhanh P. Ceppa, Daniela Molena
Journal: JAMA Surgery (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Uncoupling of IL-6 signaling and LC3-associated phagocytosis drives immunoparalysis during sepsis
Authors: Tonia Akoumianaki, Katerina Vaporidi, Eleni Diamantaki, Frédéric Pène, Remi Beau, Mark S. Gresnigt, Marina Gkountzinopulou, Maria Venichaki, Elias Drakos, Jamel El-Benna, George Samonis, Kieu T.T. Le, Vinod Kumar, Dimitrios Georgopoulos, Frank L. van de Veerdonk, Mihai G. Netea, Jean-Paul Latge, Georgios Chamilos
Journal: Cell Host & Microbe (2021)
Allogeneic Hematopoietic Stem Cell Transplantation Improves Outcome of Patients > 60 Years with Acute Myeloid Leukemia in First Complete Remission: A 10-Year Single Center Transplantation Program Analysis
Authors: Raynier Devillier, Jerome Rey, Samia Harbi, Aude Charbonnier, Sabine Furst, Colombe Saillard, Angela Granata, Evelyne D'Incan, Catherine Faucher, Claude Lemarie, Faezeh Legrand, Boris Calmels, Valerio Maisano, Bilal Mohty, Christian Chabannon, Pierre Jean Weiller, Didier Blaise, Norbert Vey
Journal: Blood (2017)
Human coronary microvascular contractile dysfunction associates with viable synthetic smooth muscle cells
Authors: Kim A Dora, Lyudmyla Borysova, Xi Ye, Chloe Powell, Timea Z Beleznai, Christopher P Stanley, Vito D Bruno, Tobias Starborg, Errin Johnson, Anna Pielach, Michael Taggart, Nicola Smart, Raimondo Ascione
Journal: Cardiovascular Research (2021)

Coronary microvascular smooth muscle cells (SMCs) respond to luminal pressure by developing myogenic tone (MT), a process integral to the regulation of microvascular perfusion. The cellular mechanisms underlying poor myogenic reactivity in patients with heart valve disease are unknown and form the focus of this study.Intramyocardial coronary micro-arteries (IMCAs) isolated from human and pig right atrial (RA) appendage and left ventricular (LV) biopsies were studied using pressure myography combined with confocal microscopy. All RA- and LV-IMCAs from organ donors and pigs developed circa 25% MT. In contrast, 44% of human RA-IMCAs from 88 patients with heart valve disease had poor (<10%) MT yet retained cell viability and an ability to raise cytoplasmic Ca2+ in response to vasoconstrictor agents. Comparing across human heart chambers and species, we found that based on patient medical history and six tests, the strongest predictor of poor MT in IMCAs was increased expression of the synthetic marker caldesmon relative to the contractile marker SM-myosin heavy chain. In addition, high resolution imaging revealed a distinct layer of longitudinally aligned SMCs between ECs and radial SMCs, and we show poor MT was associated with disruptions in these cellular alignments.These data demonstrate the first use of atrial and ventricular biopsies from patients and pigs to reveal that impaired coronary MT reflects a switch of viable SMCs towards a synthetic phenotype, rather than a loss of SMC viability. These arteries represent a model for further studies of coronary microvascular contractile dysfunction.
Evaluation of Novel Endpoints As Treatment Outcome in Allogeneic Hematopoietic Stem Cell Transplantation: A Comparison of “Classical” and “Refined” Definition of Graft-Versus Host Disease Free and Relapse Free Survival for Registry-Based Studies
Authors: Simona Pagliuca, Antonio M Risitano, Flore Sicre De Fontbrune, David Michonneau, Alban Villate, Rudy Birsen, Camille Rouzaud, Aurelien Sutra del Galy, Nabergoj Mitja, Regis Peffault De Latour, Marie Robin, Gérard Socié
Journal: Blood (2017)
Reactive oxygen species-based nanomaterials for the treatment of myocardial ischemia reperfusion injuries
Authors: Tianjiao Zhao, Wei Wu, Lihua Sui, Qiong Huang, Yayun Nan, Jianhua Liu, Kelong Ai
Journal: Bioactive Materials (2021)

Interventional coronary reperfusion strategies are widely adopted to treat acute myocardial infarction, but morbidity and mortality of acute myocardial infarction are still high. Reperfusion injuries are inevitable due to the generation of reactive oxygen species (ROS) and apoptosis of cardiac muscle cells. However, many antioxidant and anti-inflammatory drugs are largely limited by pharmacokinetics and route of administration, such as short half-life, low stability, low bioavailability, and side effects for treatment myocardial ischemia reperfusion injury. Therefore, it is necessary to develop effective drugs and technologies to address this issue. Fortunately, nanotherapies have demonstrated great opportunities for treating myocardial ischemia reperfusion injury. Compared with traditional drugs, nanodrugs can effectively increase the therapeutic effect and reduces side effects by improving pharmacokinetic and pharmacodynamic properties due to nanodrugs' size, shape, and material characteristics. In this review, the biology of ROS and molecular mechanisms of myocardial ischemia reperfusion injury are discussed. Furthermore, we summarized the applications of ROS-based nanoparticles, highlighting the latest achievements of nanotechnology researches for the treatment of myocardial ischemia reperfusion injury.
Industry Payments to Practicing US Rheumatologists, 2014–2019
Authors: Michael S. Putman, Jay E. Goldsher, Cynthia S. Crowson, Alí Duarte‐García
Journal: Arthritis & Rheumatology (2021)

Payments from the pharmaceutical industry to practicing physicians may influence prescribing behavior. This study was undertaken to investigate the nature, quantity, and geographic distribution of payments to US rheumatologists.General payments from industry sponsors to US rheumatologists from 2014 to 2019 were extracted from the Centers for Medicare and Medicaid Services Open Payments database. Gender was identified by linking physicians to the National Plan and Provider Enumeration System registry. Data were reported in aggregate, trends over time were assessed using linear regression models, and differences by gender were analyzed using the Wilcoxon rank sum test.Over the 6-year time period from 2014 to 2019, a total of 1,610,668 payments totaling $221,254,966 were made to 5,723 rheumatologists. The median payment was $15 (interquartile range [IQR] $10 to $22), and the median total amount received by individual rheumatologists over the 6-year period was $2,818 (IQR $464 to $11,560). The majority of rheumatologists (3,416 of 5,723 [60%]) received less than $5,000, but 368 of 5,723 (6%) received more than $100,000 each and accounted for 78% of the total. The yearly value of payments increased over time ($3,703,264 per year; P < 0.001), and the median payment to male rheumatologists was significantly higher than the median payment to female rheumatologists ($3,723 [IQR $542 to $15,841] versus $2,084 [IQR $394 to $8,186]; P < 0.001).The value of industry payments has increased over time, and a large amount is concentrated among a small number of rheumatologists. Future studies should investigate the degree to which industry payments have influenced prescribing in the field of rheumatology.
Massively scaled-up testing for SARS-CoV-2 RNA via next-generation sequencing of pooled and barcoded nasal and saliva samples
Authors: Joshua S. Bloom, Laila Sathe, Chetan Munugala, Eric M. Jones, Molly Gasperini, Nathan B. Lubock, Fauna Yarza, Erin M. Thompson, Kyle M. Kovary, Jimin Park, Dawn Marquette, Stephania Kay, Mark Lucas, TreQuan Love, A. Sina Booeshaghi, Oliver F. Brandenberg, Longhua Guo, James Boocock, Myles Hochman, Scott W. Simpkins, Isabella Lin, Nathan LaPierre, Duke Hong, Yi Zhang, Gabriel Oland, Bianca Judy Choe, Sukantha Chandrasekaran, Evann E. Hilt, Manish J. Butte, Robert Damoiseaux, Clifford Kravit, Aaron R. Cooper, Yi Yin, Lior Pachter, Omai B. Garner, Jonathan Flint, Eleazar Eskin, Chongyuan Luo, Sriram Kosuri, Leonid Kruglyak, Valerie A. Arboleda
Journal: Nature Biomedical Engineering (2021)
The influence of universal face mask use on endophthalmitis risk after intravitreal anti-VEGF injections during the COVID-19 pandemic.
Authors: Patel S, Tang P, Storey P, Wolfe J, Fein J, Shah S, Chen E, Abbey A, Ferrone P, Shah C, Liang M, Stem M, Khan M, Yonekawa Y, Garg S
Journal: Ophthalmology (2021)
A Distinct Mutation Profile Might Contribute to the Dismal Outcome of Triple Negative Patients with Primary Myelofibrosis
Authors: Paola Guglielmelli, Giada Rotunno, Annalisa Pacilli, Carmela Mannarelli, Chiara Paoli, Elisa Rumi, Vittorio Rosti, Tiziana Fanelli, Annalisa Franci, Francesco Mannelli, Michelle Nahas, Jie He, Nikita Agarwal, Alessandro Rambaldi, Tariq Mughal, Francesco Passamonti, Giovanni Barosi, Tiziano Barbui, Mario Cazzola, Alessandro M. Vannucchi
Journal: Blood (2017)
Abstract 284: Ovariectomy Exacerbates Mitochondrial Dysfunction, Oxidative Stress and Fibrosis to Cause Diastolic Dysfunction
Authors: Dale J Hamilton, Shumin Li, Aijun Zhang, Indira Vedula, Jessie A Smith, Anisha A Gupte
Journal: Circulation Research (2016)

Heart failure with preserved ejection fraction, characterized by diastolic dysfunction (DD) is most common in post-menopausal women, suggesting a link with estrogen (E2). However, the underlying mechanisms are not well understood. In this study we tested how ovariectomy (OVX)-induced E2-deficiency exacerbates DD. Female C57BL6/J mice (12 weeks old) underwent a sham or OVX surgery, and were administered either normal drinking water or L-N G -Nitroarginine methyl ester (L-NAME, 0.3 mg/ml in 1% NaCl solution) in the drinking water and Angiotensin II (AngII, 1.2 mg/kg/day) via subcutaneous osmotic pumps for 5 weeks to induce DD. Subsets of the OVX-DD mice were treated with E2, E2-receptor (ER) α agonist PPT, ERβ agonist DPN or G-protein ER-1 agonist G1. Echocardiography revealed reduced left ventricular (LV) internal diameter, LV volume, cardiac output but increased LV posterior wall thickness in OVX-DD mice compared with sham-DD mice. However, ejection fractions and fractional shortening were normal in all groups. Doppler studies showed E/A ratios dramatically suppressed and E/e’ ratios increased in mice treated with L-NAME+AngII, with larger changes in OVX mice. Extensive fibrosis was seen in OVX-DD hearts than sham-DD hearts. ADP-supported cardiac mitochondrial function with pyruvate-malate was moderately reduced in OVX-DD mice along with greater production of reactive oxygen species. Ionoptix studies revealed delayed relaxation but maintained contraction in cardiomyocytes isolated from OVX-DD mice, similar to effects of low-dose oligomycin in control mice. These data suggest that E2 deficiency is associated with impaired mitochondrial function to cause small decreases in ATP formation, which impair diastolic relaxation but not contraction. Treatment with E2, PPT, DPN and G1 reduced E/e’ ratios in OVX-DD mice, with the greatest effects of G1. Treatment of mice with L-NAME in this model excludes the previously described action of G1 through nitric oxide. In conclusion, OVX exacerbates mitochondrial dysfunction, oxidative stress and fibrosis in non-ischemic HF, leading to exacerbated DD. These may be some of the mechanisms by which E2 protects the myocardium in females. Activation of GPER1 offers a novel therapeutic target for DD after menopause.
Abstract 9906: Early Pulmonary Artery Banding Improves the Long-term Survival in Trisomy 18 Infants: A Receiver Operating Characteristic Curve Analysis
Authors: Kenichi Okamura, Toshihiko Suzuki, Tao Fujioka, Atsushi Nakao, Keiji Tsuchiya, Jotaro Kobayashi
Journal: Circulation (2019)

Introduction: Trisomy 18 (T18) is a genetic diagnosis often associated with cardiac malformations. Several recent studies have reported that cardiac interventions improve the survival of T18 infant...
Integrative proteomics reveals the role of E3 ubiquitin ligase SYVN1 in hepatocellular carcinoma metastasis
Authors: Feiyang Ji, Menghao Zhou, Zeyu Sun, Zhengyi Jiang, Huihui Zhu, Zhongyang Xie, Xiaoxi Ouyang, Lingjian Zhang, Lanjuan Li
Journal: Cancer Communications (2021)

Tumor metastasis is a major factor for poor prognosis of hepatocellular carcinoma (HCC), but the relationship between ubiquitination and metastasis need to be studied more systematically. We analyzed the ubiquitinome of HCC in this study to have a more comprehensive insight into human HCC metastasis.The protein ubiquitination levels in 15 HCC specimens with vascular invasion and 15 without vascular invasion were detected by ubiquitinome. Proteins with significantly different ubiquitination levels between HCCs with and without vascular invasion were used to predict E3 ubiquitin ligases associated with tumor metastasis. The topological network of protein substrates and corresponding E3 ubiquitin ligases was constructed to identify the key E3 ubiquitin ligase. Besides, the growth, migration and invasion ability of LM3 and HUH7 hepatoma cell lines with and without SYVN1 expression interference were measured by cell proliferation assay, subcutaneous tumor assay, umphal vein endothelium tube formation assay, transwell migration and invasion assays. Finally, the interacting proteins of SYVN1 were screened and verified by protein interaction omics, immunofluorescence, and immunoprecipitation. Ubiquitin levels of related protein substrates in LM3 and HUH7 cells were compared in negative control, SYVN1 knockdown, and SYVN1 overexpression groups.In this study, our whole-cell proteomic dataset and ubiquitinomic dataset contained approximately 5600 proteins and 12,000 ubiquitinated sites. We discovered increased ubiquitinated sites with shorter ubiquitin chains during the progression of HCC metastasis. In addition, proteomic and ubiquitinomic analyses revealed that high expression of E3 ubiquitin-protein ligase SYVN1 is related with tumor metastasis. Furthermore, we found that SYVN1 interacted with heat shock protein 90 (HSP90) and impacted the ubiquitination of eukaryotic elongation factor 2 kinase (EEF2K).The ubiquitination profiles of HCC with and without vascular invasion were significantly different. SYVN1 was the most important E3 ubiquitin-protein ligase responsible for this phenomenon, and it was related with tumor metastasis and growth. Therefore, SYVN1 might be a potential therapeutic target for HCC.
A genome-wide association study suggests correlations of common genetic variants with peritoneal solute transfer rates in patients with kidney failure receiving peritoneal dialysis
Authors: Rajnish Mehrotra, Ian B. Stanaway, Gail P. Jarvik, Mark Lambie, Johann Morelle, Jeffrey Perl, Jonathan Himmelfarb, Olof Heimburger, David W. Johnson, Talha H. Imam, Bruce Robinson, Peter Stenvinkel, Olivier Devuyst, Simon J. Davies, Ronald Pisoni, Bruce Robinson, David Johnson, Yeoungjee Cho, Muh Geot Wong, Amanda Mather, Bruce Cooper, Olivier Devuyst, Johann Morelle, Eric Goffin, Bert Bammens, Philippe Bovy, Peter Margetts, Jeffrey Perl, Paul Taylor, Arsh Jain, Vanita Jassal, Peter Stenvinkel, Olof Heimburger, Ying Kuan, Camille Harron, Indranil Dasgupta, John Stoves, Habib Akbani, Sumith Abeygunasekara, Edward Sharples, Paul Mead, Amer Hayat, Neal Morgan, Hilary Cramp, Susan Robertson, Richard Fielding, Edwina Brown, Helen Collinson, Pravene Ande, Tim Doulton, Iain MacDougall, Hugh Cairns, Enric Vilar, Anand Vardhan, James Chess, Kanwaljit Sandhu, Martin Wilkie, Gavin McHaffie, Robert Lewis, Lavanya Kamesh, Kate Buck, Robert Peel, Jo Taylor, Paul Johnston, Janson Leung, Coralie Bingham, Hameed Anijeet, Ramzana Asghar, Satish Ranakrishna, Sunita Nair, Neil Iggo, David Lewis, Uday Udayaraj, Susan Dawson, Graham Woordrow, Thangavelu Chandrasekar, Rizwan Hamer, Jonathan Barratt, Richard Baines, Simon Davies, Kieron Donovan, Colin Jones, Christina Ynares, Carl Dukes, Talha H. Imam, Kristin Corapi, Sagar Nigwekar, Osman Khawar, Daniel Weiner, Wei Ling Lau, Kevin Harley, Arshia Ghaffari, Ramesh Saxena, Josephine Abraham, Rajnish Mehrotra, Jonathan Himmelfarb, Kerri L. Cavanaugh, Thomas A. Golper, John M. Burkart, James L. Pirkle, Brent Miller, Judy Jang, Jeffrey Turner
Journal: Kidney International (2021)
Biomechanical and biological responses of periodontium in orthodontic tooth movement: up-date in a new decade
Authors: Yuan Li, Qi Zhan, Minyue Bao, Jianru Yi, Yu Li
Journal: International Journal of Oral Science (2021)

Abstract Nowadays, orthodontic treatment has become increasingly popular. However, the biological mechanisms of orthodontic tooth movement (OTM) have not been fully elucidated. We were aiming to summarize the evidences regarding the mechanisms of OTM. Firstly, we introduced the research models as a basis for further discussion of mechanisms. Secondly, we proposed a new hypothesis regarding the primary roles of periodontal ligament cells (PDLCs) and osteocytes involved in OTM mechanisms and summarized the biomechanical and biological responses of the periodontium in OTM through four steps, basically in OTM temporal sequences, as follows: (1) Extracellular mechanobiology of periodontium: biological, mechanical, and material changes of acellular components in periodontium under orthodontic forces were introduced. (2) Cell strain: the sensing, transduction, and regulation of mechanical stimuli in PDLCs and osteocytes. (3) Cell activation and differentiation: the activation and differentiation mechanisms of osteoblast and osteoclast, the force-induced sterile inflammation, and the communication networks consisting of sensors and effectors. (4) Tissue remodeling: the remodeling of bone and periodontal ligament (PDL) in the compression side and tension side responding to mechanical stimuli and root resorption. Lastly, we talked about the clinical implications of the updated OTM mechanisms, regarding optimal orthodontic force (OOF), acceleration of OTM, and prevention of root resorption.