tbuckley/cabot-search huggingface dataset:
Abstract 301: CITED4 Gene Therapy Alters Maladaptive Cardiac Remodeling After Ischemia-reperfusion Injury
Authors: Carolin Lerchenmüller, Charles P Rabolli, Dongjian Hu, Vassilios J Bezzerides, Colin Platt, Laura Liu, Patrick Most, Anthony Rosenzweig
Journal: Circulation Research (2017)

Introduction: Cardiac hypertrophy is an adaptive response to increased physiologic or pathologic hemodynamic stress. Previous work from our laboratory suggested that the CEBPβ/ CITED4 pathway plays an important role in exercise-induced cardiac hypertrophy. Consistent with this model, our laboratory recently found that inducible cardiac expression of CITED4 in adult mice increases in heart weight and cardiomyocyte size with normal systolic function and a gene expression profile consistent with physiologic growth. After ischemia-reperfusion injury (IRI), induced CITED4 mice show significant functional recovery and evidence for decreased adverse remodeling. Hypothesis: Here, we assessed the hypothesis that CITED4 gene therapy delivered in a clinically relevant time frame after IRI in a mouse model, will also lead to improved systolic function and favorable cardiac remodeling. Methods and Results: Cardiomyocyte-specific CITED4 gene delivery via intravenous AAV9 (CITED4 and GFP control) injections in young wild type (WT) mice led to a steady 4-fold increase in cardiac CITED4 expression. After four weeks, CITED4 treated animals developed physiologic cardiac hypertrophy with increased heart weights (heart weight to tibia length controls 6.54±0.17g/mm vs. CITED4 7.31±0.12g/mm), as well as increased left ventricular mass index and wall thickness with unchanged systolic function evaluated by echocardiography. CITED4 gene therapy in the setting of IRI, delivered 20min. after reperfusion, promoted decreased maladaptive remodeling with improved systolic function (%FS controls 37.5±3.6 vs. C4KO 47.9±1.6), a smaller scar size (% fibrotic area controls 9.1±1.9 vs. C4KO 2.4±0.5) and a favorable gene expression profile eight weeks after IRI. After injury, CITED4 gene therapy led to a 6-fold overexpression already after one week post-IRI, responsible for less apoptosis, fibrosis and inflammation when compared to control mice. Conclusion: Taken together, our data identify CITED4 as a regulator of physiologic cardiac growth that protects against adverse remodeling after ischemic injury in a clinically relevant therapeutic intervention after IRI. CITED4 may represent a novel therapeutic target to mitigate adverse ventricular remodeling.
Epigenetic Loss of the HLA-DR15 Expression on Hematopoietic Stem Progenitor Cells in Patients with Acquired Aplastic Anemia Characterized By Cyclosporine Dependency: A Novel Mechanism Underlying the Immune Escape of Hematopoietic Stem Progenitor Cells
Authors: Noriaki Tsuji, Kohei Hosokawa, Ryota Urushihara, Mikoto Tanabe, Hiroyuki Takamatsu, Ken Ishiyama, Hirohito Yamazaki, Shinji Nakao
Journal: Blood (2020)
Biomolecule‐Directed Carbon Nanotube Self‐Assembly
Authors: Eduardo Anaya‐Plaza, Ahmed Shaukat, Inka Lehtonen, Mauri A. Kostiainen
Journal: Advanced Healthcare Materials (2020)

Abstract The strategy of combining biomolecules and synthetic components to develop biohybrids is becoming increasingly popular for preparing highly customized and biocompatible functional materials. Carbon nanotubes (CNTs) benefit from bioconjugation, allowing their excellent properties to be applied to biomedical applications. This study reviews the state‐of‐the‐art research in biomolecule–CNT conjugates and discusses strategies for their self‐assembly into hierarchical structures. The review focuses on various highly ordered structures and the interesting properties resulting from the structural order. Hence, CNTs conjugated with the most relevant biomolecules, such as nucleic acids, peptides, proteins, saccharides, and lipids are discussed. The resulting well‐defined composites allow the nanoscale properties of the CNTs to be exploited at the micro‐ and macroscale, with potential applications in tissue engineering, sensors, and wearable electronics. This review presents the underlying chemistry behind the CNT‐based biohybrid materials and discusses the future directions of the field.
Germline <i>POT1</i> Variants Can Predispose to a Variety of Hematologic Neoplasms
Authors: Tristan L. Lim, David B. Lieberman, Adam R. Davis, Ryan Hausler, Ashkan Bigdeli, Yimei Li, Jacquelyn Powers, Regeneron Genetics Center, Shannon A. Carty, Katherine L. Nathanson, Adam Bagg, Elizabeth O. Hexner, Kara N. Maxwell, Jennifer J.D. Morrissette, Daria V. Babushok
Journal: Blood (2020)
Clinical benefit of the multibending endoscope for gastric endoscopic submucosal dissection: a randomized controlled trial
Authors: Koichi Hamada, Yoshinori Horikawa, Yoshiki Shiwa, Kae Techigawara, Takayuki Nagahashi, Daizo Fukushima, Shinya Nishida, Ryota Koyanagi, Koichiro Kawano, Noriyuki Nishino, Michitaka Honda
Journal: Endoscopy (2020)

Abstract Background Endoscopic submucosal dissection (ESD) is a technically difficult and time-consuming procedure. We aimed to investigate the efficacy and safety of ESD using a multibending endoscope to treat superficial gastrointestinal neoplasms. Methods Patients with a single early gastric cancer who met the absolute or expanded indications for ESD according to the Japanese gastric cancer treatment guidelines were enrolled and randomly assigned to undergo ESD using a conventional endoscope (C-ESD) or a multibending endoscope (M-ESD). Randomization was stratified by ESD operator experience and tumor location. The primary outcome was ESD procedure time, calculated as the time from the start of submucosal injection to complete removal of the tumor. Results 60 patients were analyzed (30 C-ESD, 30 M-ESD). The mean (standard deviation [SD]) ESD procedure times for M-ESD and C-ESD were 34.6 (SD 17.2) and 47.2 (SD 26.7) minutes, respectively (P = 0.03). Muscle layer damage occurred significantly less frequently with M-ESD (0.2 [SD 0.7] vs. 0.7 [SD 1.0]; P = 0.04). There were no significant differences between the two techniques in procedure time or damage to muscle layers for tumors located in the lower third of the stomach. Conclusions ESD procedure time was significantly shorter with the multibending endoscope and fewer muscles were damaged. We recommend multibending endoscopy for ESD in the upper and middle thirds of the stomach to reduce procedure time and incidence of complications.
Transplant Outcomes with Fludarabine and Melphalan in High Risk AML Patients By Donor Types
Authors: Betul Oran, Stefan O. Ciurea, Rohtesh S. Mehta, Amin M. Alousi, Gabriela Rondon, Uday R. Popat, David Marin, May Daher, Jin S. Im, Partow Kebriaei, Gheath Alatrash, Richard E. Champlin
Journal: Blood (2020)
Machine Learning-Based Approach to Predict Survival after Allogeneic Hematopoietic Cell Transplantation in Hematologic Malignancies
Authors: Eun-Ji Choi, Je-Hwan Lee, Jun-Hong Park, Han-Seung Park, Jung-Hee Lee, Youngshin Lee, Young-Ah Kang, Mijin Jeon, Ji Min Woo, Hyeran Kang, Kyoo Hyung Lee
Journal: Blood (2020)
Detailed Immunophenotypic Profiling of Peripheral Blood Immune Cells in Patients with Hematologic Malignancies after Sars-Cov-2 Infection
Authors: Forat Lutfi, Jonathan Siglin, Gabriela Sanchez-Petitto, Ali Bukhari, David Gottlieb, Dong Won Kim, Brandon Cooper, Michelle Fleyshman, Diego De Miguel Perez, Michael Kleinberg, Rena G Lapidus, Aaron P. Rapoport, Xiaoxuan Fan, Saurabh Dahiya
Journal: Blood (2020)
Abstract 428: Cortical Bone Stem Cell-derived Exosomes Reduce Myofibroblast Activation in Rat and Human Cardiac Fibroblasts
Authors: Giana Schena, Hajime KUBO, Eric Feldsott, Alaina Headrick, Keith Koch, Yijun Yang, Sadia Mohsin, Timothy McKinsey, Steve Houser
Journal: Circulation Research (2020)

Rationale: Heart failure is the one of the leading causes of death in the United States. Post-myocardial infarction is followed by cardiac remodeling that involves extensive fibrosis and ultimately progresses into heart failure. We have seen improvements in scar size and cardiac function as a result of administration of cortical bone stem cell-derived (CBSC) exosomes. Objectives: We investigated the mechanism through which CBSC-derived exosomes altered wound healing and reduced scar formation through in vitro experimentation. We continue to broaden our understanding of how CBSCs exert their anti-fibrotic effects. Methods and Results: We cultured adult rat ventricular fibroblasts and adult human cardiac fibroblasts and treated them +/- TGF β with mouse and human CBSC-derived exosomes, respectively. We saw a dose-dependent decrease in myofibroblast activation with increasing concentrations of mCBSC and hCBSC exosomes, with 100 fold decrease compared to baseline fibroblast activation in hCBSC treated cardiac fibroblasts (9.5 x 10 5 of 1.6 x 10 7 intensity), and by 40% in mCBSC treated cardiac fibroblasts (2.4 x 10 5 of 1.0 x 10 6 intensity). In the presence of TGFβ and 2.0 x 10 6 exosome particles/cell treated, the αSMA levels were still reduced by nearly 50% vs TGFβ alone (1.2 x 10 6 of 2.2 x 10 7 intensity). We performed RNA sequencing on both the rat and human cardiac fibroblasts in order to discover which fibrosis-related genes were being altered by CBSC exosomes treatment. Conclusions: Our findings show that the wound healing induced by CBSC exosome treatment post-MI involves the reduction of myofibroblast activation and decreasing the production of pro-fibrotic mRNA in cardiac fibroblasts and cardiac endothelial cells.
SOX2 promotes resistance of melanoma with PD-L1 high expression to T-cell-mediated cytotoxicity that can be reversed by SAHA
Authors: Ruiyan Wu, Caiqin Wang, Zhiming Li, Jian Xiao, Chunyan Li, Xuemin Wang, Pengfei Kong, Jianghua Cao, Fuxue Huang, Zhiling Li, Yun Huang, Yuhong Chen, Xuan Li, Dong Yang, Hailiang Zhang, Jia Mai, Gongkan Feng, Rong Deng, Xiaofeng Zhu
Journal: Journal for ImmunoTherapy of Cancer (2020)

Background Immune checkpoint inhibitors (ICIs) induce better tumor regression in melanoma with programmed cell death 1 ligand 1 (PD-L1) high expression, but there has been an upsurge of failed responses. In this study, we aimed to explore the additional mechanisms possibly accounting for ICIs resistance and interventional strategies to overcome the resistance in melanoma with PD-L1 high expression. Methods Melanoma xenografts and cytotoxicity assays were used to investigate function of SOX2 in regulating antitumor immunity. The activity of the janus kinase-signal transducer and activator of transcriptions (JAK-STAT) pathway was investigated by western blots, quantitative PCR and luciferase assay. Epigenetic compounds library screen was employed to identify inhibitors that could decrease SOX2 level. The effect of histone deacetylase inhibitor SAHA in antitumor immunity alone or in combination with immunotherapy was also determined in vitro and in vivo. Prognostic impact of SOX2 was analyzed using transcriptional profiles and clinical data download from the Gene Expression Omnibus and The Cancer Genome Atlas repository. Results We uncovered a role of SOX2 in attenuating the sensitivity of melanoma cells to CD8+ T-cell killing. Mechanistically, SOX2 inhibited phosphatases suppressor of cytokine signaling 3 (SOCS3) and protein tyrosine phosphatase non-receptor type 1 (PTPN1) transcription, induced duration activation of the JAK-STAT pathway and thereby overexpression of interferon stimulated genes resistance signature (ISG.RS). By targeting the SOX2-JAK-STAT signaling, SAHA promoted the antitumor efficacy of IFNγ or anti-PD-1 in vitro and in vivo. Moreover, SOX2 was an independent prognostic factor for poor survival and resistant to anti-PD-1 therapy in melanoma with PD-L1 high expression. Conclusions Our data unveiled an additional function of SOX2 causing immune evasion of CD8+ T-cell killing through alleviating the JAK-STAT pathway and ISG.RS expression. We also provided a rationale to explore a novel combination of ICIs with SAHA clinically, especially in melanoma with PD-L1 and SOX2 high expression.
Thrombotic Microangiopathy Variants Are Independently Associated with Critical Disease in COVID-19 Patients
Authors: Eleni Gavriilaki, Styliani Kokoris, Tasoula Touloumenidou, Evdoxia Koravou, Maria Koutra, Vassiliki Karali, Lila Papalexandri, Fani Chatzopoulou, Maria Chatzidimitriou, Dimitrios Chatzidimitriou, Anastasia Veleni, Savvas Grigoriadis, Eulampia Konstantinidou, Diamantis Chloros, Ioannis Kioumis, Evaggelos Kaimakamis, Milly Bitzani, Dimitrios Boumpas, Argyrios Tsantes, Damianos Sotiropoulos, Ioanna Sakellari, Achilles Anagnostopoulos
Journal: Blood (2020)
Therapy-Related Myeloid Neoplasm Has a Distinct Pro-Inflammatory Bone Marrow Microenvironment and Delayed DNA Damage Repair
Authors: Monika M Kutyna, Li Yan A Wee, Sharon Paton, Dimitrios Cakouros, Agnieszka Arthur, Rakchha Chhetri, Andreas W Schreiber, Chung Hoow Kok, Deepak Singhal, Daniel Thomas, Timothy P. Hughes, David Campbell, Stan Gronthos, Devendra K Hiwase
Journal: Blood (2020)
Artificial Intelligence Substantially Supports Chromosome Banding Analysis Maintaining Its Strengths in Hematologic Diagnostics Even in the Era of Newer Technologies
Authors: Claudia Haferlach, Siegfried Hänselmann, Wencke Walter, Sarah Volkert, Melanie Zenger, Wolfgang Kern, Anna Stengel, Thomas Lörch, Torsten Haferlach
Journal: Blood (2020)
The Safety and Efficacy of a CRISPR/Cas9-Engineered Universal CAR-T Cell Product (CTA101) in Patients with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia
Authors: Yongxian Hu, Yali Zhou, Mingming Zhang, Wengang Ge, Yi Li, Li Yang, Guoqing Wei, Lu Han, Hao Wang, Xingwang Zhang, Jiangtao Ren, He Huang
Journal: Blood (2020)
Integrative DNA Methylation and Gene Expression Analysis Reveals Candidate Biomarkers Associated with Dichotomized Response to Chemoimmunotherapy in Diffuse Large B-Cell Lymphoma
Authors: Ellen K. Kendall, Manishkumar S. Patel, Sarah Ondrejka, Agrima Mian, Yazeed Sawalha, Bo Hu, Eric D. Hsi, Brian T. Hill, Neetu Gupta
Journal: Blood (2020)
Preclinical Evaluation of a Novel MALT1 Inhibitor CTX-177 for Relapse/Refractory Lymphomas
Authors: Daisuke Morishita, Akio Mizutani, Hirokazu Tozaki, Yasuyoshi Arikawa, Takuro Kameda, Ayako Kamiunten, Keisuke Kataoka, Akinori Yoda, Yotaro Ochi, Kotaro Shide, Koji Izutsu, Yosuke Minami, Kazuya Shimoda, Hiroshi Miyake, Seishi Ogawa
Journal: Blood (2020)
The long noncoding RNA <i>MALAT1</i> suppresses miR‐211 to confer protection from ultraviolet‐mediated DNA damage in vitiligo epidermis by upregulating sirtuin 1*
Authors: H.D. Brahmbhatt, R. Gupta, A. Gupta, S. Rastogi, R. Misri, A. Mobeen, A. Ghosh, P. Kothari, S. Sitaniya, V. Scaria, A. Singh
Journal: British Journal of Dermatology (2020)

The absence of melanocytes poses a challenge for long-term tissue homeostasis in vitiligo. Surprisingly, while individuals with Fitzpatrick phototypes I-II (low melanin content) have a higher incidence of melanoma and nonmelanoma skin cancer, people with vitiligo are at a decreased risk for the same.To understand the molecular mechanisms that protect vitiligo skin from ultraviolet (UV)-induced DNA damage by (i) characterizing differentially expressed microRNAs in lesional vs. nonlesional epidermis and (ii) identifying their upstream regulators and downstream gene targets.Genome-wide microRNA profiling of nonlesional and lesional epidermis was performed on five individuals with stable nonsegmental vitiligo using next-generation RNA sequencing. The relevance of the upstream regulator and downstream target gene of the most differentially expressed microRNA was studied.Our study found sirtuin1 (SIRT1), an NAD-dependent deacetylase, to be a direct target of miR-211 - the most significantly downregulated microRNA in lesional epidermis. Inhibition of SIRT1 with EX-527 downregulated keratin 10 and involucrin, suggesting that SIRT1 promotes keratinocyte differentiation. Overexpression of miR-211 mimic led to a significant increase in γ-H2AX positivity and cyclobutane pyrimidine dimer (CPD) formation, hallmarks of UVB-mediated DNA damage. These effects could be ameliorated by the addition of resveratrol, a SIRT1 activator. Furthermore, a long noncoding RNA, MALAT1, was identified as a negative upstream regulator of miR-211. Overexpression of MALAT1 resulted in increased expression of SIRT1 and a concomitant removal of UVB-induced CPDs in primary keratinocytes.These findings establish a novel MALAT1-miR-211-SIRT1 signalling axis that potentially confers protection to the 'amelanotic' keratinocytes in vitiligo.
Noradrenergic fibers are associated with beta-cell dedifferentiation and impaired beta-cell function in humans
Authors: F. Cinti, T. Mezza, I. Severi, M. Suleiman, C.M.A. Cefalo, G.P. Sorice, S. Moffa, F. Impronta, G. Quero, S. Alfieri, A. Mari, A. Pontecorvi, L. Marselli, S. Cinti, P. Marchetti, A. Giaccari
Journal: Metabolism (2020)

Type 2 diabetes (T2D) is characterized by a progressive loss of beta-cell function, and the "disappearance" of beta-cells in T2D may also be caused by the process of beta -cell dedifferentiation. Since noradrenergic innervation inhibits insulin secretion and density of noradrenergic fibers is increased in type 2 diabetes mouse models, we aimed to study the relation between islet innervation, dedifferentiation and beta-cell function in humans.Using immunohistochemistry and electron microscopy, we analyzed pancreata from organ donors and from patients undergoing pancreatic surgery. In the latter, a pre-surgical detailed metabolic characterization by oral glucose tolerance test (OGTT) and hyperglycemic clamp was performed before surgery, thus obtaining in vivo functional parameters of beta-cell function and insulin secretion.The islets of diabetic subjects were 3 times more innervated than controls (0.91 ± 0.21 vs 0.32 ± 0.10, n.fibers/islet; p = 0.01), and directly correlated with the dedifferentiation score (r = 0.39; p = 0.03). In vivo functional parameters of insulin secretion, assessed by hyperglycemic clamp, negatively correlated with the increase in fibers [beta-cell Glucose Sensitivity (r = -0.84; p = 0.01), incremental second-phase insulin secretion (r = -0.84, p = 0.03) and arginine-stimulated insulin secretion (r = -0.76, p = 0.04)]. Moreover, we observed a progressive increase in fibers, paralleling worsening glucose tolerance (from NGT through IGT to T2D).Noradrenergic fibers are significantly increased in the islets of diabetic subjects and this positively correlates with beta-cell dedifferentiation score. The correlation between in vivo insulin secretion parameters and the density of pancreatic noradrenergic fibers suggests a significant involvement of these fibers in the pathogenesis of the disease, and indirectly, in the islet dedifferentiation process.
Duplex Sequencing with Patient-Specific Hybrid Capture Panels Reveals Ultra-Low Frequency Measurable Residual Disease in Pediatric Acute Myeloid Leukemia
Authors: Jacob Higgins, Fang Yin Lo, Michael J. Hipp, Charles C. Valentine, Lindsey N. Williams, Amanda R. Leonti, Rhonda E. Ries, Jerald P. Radich, Soheil Meshinchi, Benjamin J. Huang, Jesse J. Salk
Journal: Blood (2020)
Effects of 2-Year Walnut-Supplemented Diet on Inflammatory Biomarkers
Authors: Montserrat Cofán, Sujatha Rajaram, Aleix Sala-Vila, Cinta Valls-Pedret, Mercè Serra-Mir, Irene Roth, Tania M. Freitas-Simoes, Edward Bitok, Joan Sabaté, Emilio Ros
Journal: Journal of the American College of Cardiology (2020)
Weekly Carfilzomib, Lenalidomide, Dexamethasone and Daratumumab (wKRd-D) Combination Therapy in Newly Diagnosed Multiple Myeloma: Final Results from a Clinical and Correlative Phase 2 Study
Authors: Ola Landgren, Malin Hultcrantz, Alexander M. Lesokhin, Sham Mailankody, Hani Hassoun, Carlyn Tan, Urvi A Shah, Sydney X. Lu, Benjamin Diamond, Meghan Salcedo, Kelly Werner, Jenna Rispoli, Julia Caple, Allison Sams, Dennis Verducci, Katie Jones, Isabel Concepcion, Ciardello Amanda, Aisara Chansakul, Julia Schlossman, Elizabet Tavitian, Tala Shekarkhand, Angela Harrison, Casey Piacentini, Even H Rustad, Venkata Yellapantula, Francesco Maura, Heather J Landau, Michael Scordo, David J. Chung, Gunjan Shah, Oscar B Lahoud, Katie Thoren, Kazunori Murata, Lakshmi Ramanathan, Maria E. Arcila, Caleb Ho, Mikhail Roshal, Ahmet Dogan, Andriy Derkach, Sergio A. Giralt, Neha Korde
Journal: Blood (2020)
Deep learning from “passive feeding” to “selective eating” of real-world data
Authors: Zhongwen Li, Chong Guo, Danyao Nie, Duoru Lin, Yi Zhu, Chuan Chen, Lanqin Zhao, Xiaohang Wu, Meimei Dongye, Fabao Xu, Chenjin Jin, Ping Zhang, Yu Han, Pisong Yan, Haotian Lin
Journal: npj Digital Medicine (2020)

Artificial intelligence (AI) based on deep learning has shown excellent diagnostic performance in detecting various diseases with good-quality clinical images. Recently, AI diagnostic systems developed from ultra-widefield fundus (UWF) images have become popular standard-of-care tools in screening for ocular fundus diseases. However, in real-world settings, these systems must base their diagnoses on images with uncontrolled quality ("passive feeding"), leading to uncertainty about their performance. Here, using 40,562 UWF images, we develop a deep learning-based image filtering system (DLIFS) for detecting and filtering out poor-quality images in an automated fashion such that only good-quality images are transferred to the subsequent AI diagnostic system ("selective eating"). In three independent datasets from different clinical institutions, the DLIFS performed well with sensitivities of 96.9%, 95.6% and 96.6%, and specificities of 96.6%, 97.9% and 98.8%, respectively. Furthermore, we show that the application of our DLIFS significantly improves the performance of established AI diagnostic systems in real-world settings. Our work demonstrates that "selective eating" of real-world data is necessary and needs to be considered in the development of image-based AI systems.
Increased Risk of for Cytomegalovirus Reactivation after Allogeneic HSCT in T-Cell Depleted Patients
Authors: Vinicius Campos Molla, Roberta Azevedo, Jessica Fernandes Ramos, Danilo Belchior Ponciano, Pedro Henrique Arruda de Moraes, Ana Rita Da Fonseca, Maria Cristina Nunez Seiwald, Mariana Serpa, Aliana Meneses Ferreira, Roberta Shcolnik Szor, Rayana Bomfim Leonel, Erick Menezes Xavier, Vanderson Rocha, Luciana Tucunduva, Yana Novis, Marcio Nucci, Esper Kallas, Celso Arrais
Journal: Blood (2020)
Expanding Use of a Modified Pediatric Intensive Regimen for Acute Lymphoblastic Leukemia (ALL) into an Older Adult Population: Feasibility and Efficacy Results
Authors: Anand Ashwin Patel, Joseph Heng, Emily Dworkin, Sarah Monick, Benjamin A Derman, Sandeep Gurbuxani, Satyajit Kosuri, Hongtao Liu, Michael Thirman, Lucy A. Godley, Olatoyosi Odenike, Richard A. Larson, Wendy Stock
Journal: Blood (2020)
Outcomes of patients with hematologic malignancies and COVID-19: a systematic review and meta-analysis of 3377 patients
Authors: Abi Vijenthira, Inna Y. Gong, Thomas A. Fox, Stephen Booth, Gordon Cook, Bruno Fattizzo, Fernando Martín-Moro, Jerome Razanamahery, John C. Riches, Jeff Zwicker, Rushad Patell, Marie Christiane Vekemans, Lydia Scarfò, Thomas Chatzikonstantinou, Halil Yildiz, Raphaël Lattenist, Ioannis Mantzaris, William A. Wood, Lisa K. Hicks
Journal: Blood (2020)
Impact of Hematologists' Personality and Behavioral Traits on Medical Decision-Making for Elderly Acute Myeloid Leukemia: A National Study in China
Authors: Xia Wu, Yi-Nan Jiang, Yue-Lun Zhang, Jia Chen, Yue-ying Mao, Lu Zhang, Dao-Bin Zhou, Xinxin Cao, Jian Li
Journal: Blood (2020)
Internal mammary and medial supraclavicular lymph node chain irradiation in stage I–III breast cancer (EORTC 22922/10925): 15-year results of a randomised, phase 3 trial
Authors: Philip M Poortmans, Caroline Weltens, Catherine Fortpied, Carine Kirkove, Karine Peignaux-Casasnovas, Volker Budach, Femke van der Leij, Ernest Vonk, Nicola Weidner, Sofia Rivera, Geertjan van Tienhoven, Alain Fourquet, Georges Noel, Mariacarla Valli, Matthias Guckenberger, Eveline Koiter, Severine Racadot, Roxolyana Abdah-Bortnyak, Erik F Van Limbergen, Antoine Engelen, Peter De Brouwer, Henk Struikmans, Harry Bartelink
Journal: The Lancet Oncology (2020)