tbuckley/cabot-search huggingface dataset:
Association of early alpha-fetoprotein response with survival in patients with HBV-related hepatocellular carcinoma receiving lenvatinib.
Authors: Nanya Wang, Jiyu Shi, Bo Liu
Journal: Journal of Clinical Oncology (2022)

448 Background: Lenvatinib is a standard first-line treatment for unresectable hepatocellular carcinoma (uHCC). We assessed the value of early alpha-fetoprotein (AFP) response for predicting clinical outcomes to lenvatinib treatment in patients with HBV-related uHCC and elevated AFP levels. Methods: This was a retrospective analysis of the medical records of consecutive patients with HBV-related uHCC and baseline AFP levels ≥20 ng/ml who received lenvatinib for &gt; 1 month at The First Hospital of Jilin University between November 2018 and May 2021. Early AFP response was defined as a &gt; 20% decrease in AFP serum level from baseline after 4 weeks of lenvatinib treatment. We evaluated radiological response using Response Evaluation Criteria in Solid Tumors (RECIST) v1.1, as well as progression-free survival (PFS), and overall survival (OS) in AFP responders and non-responders. Potential prognostic factors for PFS and OS were assessed using univariate and multivariate Cox proportional hazards models. Intergroup differences were compared using a Mann–Whitney U test for continuous variables, a Fisher’s exact test for categorical variables and a log–rank test for survival data. Results: Medical records from 79 patients were screened and a total of 46 patients were included in the analysis; 84.4% had received lenvatinib in first-line, 63% were Child-Pugh class A, 56.4% had extrahepatic metastases, 35.6% had portal vein thrombosis and 10.3% and 87.2% had BCLC stage B and C disease, respectively. Of the 46 patients, 65.2% (n = 30) were early AFP responders and 34.8% (n = 16) were AFP non-responders. Baseline characteristics were balanced between early AFP responders and non-responders, except for age (≥60 years: 43.3% vs. 12.5%; p = 0.0366) and presence of portal vein thrombosis (46.7% vs. 13.3%; p = 0.0277). The median follow-up time was 18.0 (IQR, 3-29) months. Early AFP responders versus non-responders had a significantly higher objective response rate (34.5% vs 6.3%, p = 0.0349), disease control rate (82.8% vs 50.0%; p = 0.0203) and a longer median PFS (13.0 vs 7.0 months; HR, 0.464; 95% CI, 0.222-0.967; p = 0.028). Multivariate analysis confirmed that early AFP response (HR, 0.366; 95% CI, 0.169-0.795; p = 0.0110), ECOG PS of 0 (HR, 0.497; 95% CI, 0.323-0.877; p = 0.0326) and ALBI grade 1 (HR, 0.411; 95% CI, 0.277-0.863; p = 0.0283) were independent prognostic factors for longer PFS. Conclusions: AFP is an important prognostic factor and a predictive biomarker of survival benefit for patients with HBV-related uHCC receiving treatment with lenvatinib.
Error in Figure Value
Authors: Srishti Saha, Piyush Nathani, Arjun Gupta
Journal: JAMA Internal Medicine (2021)

Jerry H. Gurwitz, MD; Alok Kapoor, MD, MSc; Lawrence Garber, MD; Kathleen M. Mazor, EdD; Joann Wagner, MSW; Sarah L. Cutrona, MD, MPH; Sonal Singh, MD, MPH; Abir O. Kanaan, PharmD; Jennifer L. Donovan, PharmD; Sybil Crawford, PhD, MS; Kathryn Anzuoni, MPH; Timothy J. Konola, BA; Yanhua Zhou, MS; Terry S. Field, DSc
P-130 Real-world outcomes of patients with colorectal liver metastases treated with transarterial radioembolization: Results from CIRT, a large European, prospective multi-centre, observational study
Authors: N. Schaefer, B. Sangro, F. Kolligs, G. Maleux, M. Pech, C. Soydal, T. Pfammatter, G. Groezinger, N. de Jong, T. Helmberger
Journal: Annals of Oncology (2021)
SOCIETY NEWS.
Authors: Charles McIntire
Journal: JAMA (1896)

<h3>American Academy of Medicine.</h3> —Preliminary "press notice" of the twenty-first annual session at Atlanta, Ga.: The twenty-first annual session of the American Academy of Medicine will be held at the Hotel Aragon, Atlanta, Ga., Saturday, May 2, and Monday, May 4, 1896. The proprietors of the Aragon have made special rates for those who attend the meeting; it is expected that the concession for one and one-third fare for the round trip granted to theAmerican Medical Associationwill be available in time for those who desire to attend the opening session; a pleasant excursion can be arranged to start from Philadelphia and visit Asheville, N. C., the "Land of the Sky," and Chattanooga,<i>en route</i>to Atlanta, if a sufficient number club together for that purpose; or special Pullman cars can be chartered for the exclusive use of those who attend the meeting for the direct route to Atlanta
Шановні колеги!
Authors: . .
Journal: GASTROENTEROLOGY (2013)

Останніми роками розвиток медичної допомоги привертає підвищену увагу не лише медичних працівників, а й усього суспільства в цілому як у нашій країні, так і за кордоном. Багато в чому це обумовлено зростанням соціально значущих хвороб, у тому числі хвороб органів травлення, поширеність яких сьогодні в структурі загальної захворюваності в Україні займає третє місце після серцево-судинних захворювань і хвороб органів дихання. Патогенез хвороб органів травлення складний, багатогранний і не до кінця вивчений.
Three-dose vaccination elicits neutralising antibodies against omicron
Authors: Mary Wu, Emma C Wall, Edward J Carr, Ruth Harvey, Hermaleigh Townsley, Harriet V Mears, Lorin Adams, Svend Kjaer, Gavin Kelly, Scott Warchal, Chelsea Sawyer, Caitlin Kavanagh, Christophe J Queval, Yenting Ngai, Emine Hatipoglu, Karen Ambrose, Steve Hindmarsh, Rupert Beale, Steve Gamblin, Michael Howell, George Kassiotis, Vincenzo Libri, Bryan Williams, Sonia Gandhi, Charles Swanton, David LV Bauer
Journal: The Lancet (2022)
Syllabus of Lectures on Human Embryology:
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prioritising children's rights in the COVID-19 response
Authors: None The Lancet Child & Adolescent Health
Journal: The Lancet Child & Adolescent Health (2020)

Although substantial progress has been made in many aspects of child health in the past two decades, the COVID-19 pandemic and its wide-ranging effects are threatening some of these hard-won gains. Public health measures such as lockdown, school closures, and restrictions in population movement—while necessary to halt virus transmission—are causing prolonged disruption to societal functioning and exacerbating inequalities worldwide. The global Human Development Index (HDI) is projected to decline this year for the first time since 1990, effectively erasing all progress in human development made in the past 6 years.
Fat or fit: Does it matter what women weigh? The NHLBI-sponsored WISE study C. N. Bairey Merz, Marian B. Olson, B. D. Johnson, Carl J. Pepine, Steven E. Reis, William J. Rogers, Nathaniel Reichek, Barry L. Sharaf, Sheryl F. Kelsey, George Sopko. Cedars-Sinai Medical Center, Los Angeles
Journal: Journal of the American College of Cardiology (2001)
AN ADAMLESS EDEN.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Granulocyte colony‐stimulating factor and its receptor in acute promyelocytic leukemia
Authors: Naoyuki Katayama, Kenkichi Kita, Keiki Kawakami, Hidetsugu Mitani, Takayuki Sugawara, Satoroh Mizuno, Akihito Yonezawa, Kazuhiro Nishii, Hiroshi Miwa, Hideo Wada, Nobuyuki Minami, Hiroshi Shiku
Journal: American Journal of Hematology (1998)

Expression of granulocyte colony-stimulating factor (G-CSF) receptor (G-CSFR) and in vitro proliferative response to G-CSF were investigated by quantitative immunofluorescence and [3H] thymidine uptake, respectively, in a series of acute myeloid leukemias (AML). The results indicated that G-CSFR was detected at high levels in acute promyelocytic leukemia (APL) cells, in comparison with other types of AML. Moreover, APL cells were also seen to predominantly proliferate in response to G-CSF. Based on these observations, we administered recombinant human G-CSF to a patient with APL in the third relapse that was resistant to both cytotoxic agents and all trans retinoic acid, in an attempt to sensitize the leukemic cells to cell-cycle-dependent agents. Complete remission was achieved. The finding that APL cells are exquisitely responsive to G-CSF supports the view that G-CSF is useful for augmentation of their vulnerability to cell-cycle specific agents. Am. J. Hematol. 58:31–35, 1998. © 1998 Wiley-Liss, Inc.
Synergism, Bifunctionality, and the Evolution of a Gradual Sensory Trade-off in Hummingbird Taste Receptors
Authors: Glenn Cockburn, Meng-Ching Ko, Keren R Sadanandan, Eliot T Miller, Tomoya Nakagita, Amanda Monte, Sungbo Cho, Eugeni Roura, Yasuka Toda, Maude W Baldwin
Journal: Molecular Biology and Evolution (2021)

Sensory receptor evolution can imply trade-offs between ligands, but the extent to which such trade-offs occur and the underlying processes shaping their evolution is not well understood. For example, hummingbirds have repurposed their ancestral savory receptor (T1R1-T1R3) to detect sugars, but the impact of this sensory shift on amino acid perception is unclear. Here, we use functional and behavioral approaches to show that the hummingbird T1R1-T1R3 acts as a bifunctional receptor responsive to both sugars and amino acids. Our comparative analyses reveal substantial functional diversity across the hummingbird radiation and suggest an evolutionary timeline for T1R1-T1R3 retuning. Finally, we identify a novel form of synergism between sugars and amino acids in vertebrate taste receptors. This work uncovers an unexplored axis of sensory diversity, suggesting new ways in which nectar chemistry and pollinator preferences can coevolve.
Distribution of STD Clinic Patients Along a Stages-of-Behavioral-Change Continuum— Selected Sites, 1993
Journal: JAMA (1993)

Human immunodeficiency virus (HIV) counseling and testing are important components of the public health effort to contain the acquired immunodeficiency syndrome (AIDS) epidemic. Project RESPECT is a multicenter randomized trial being conducted by CDC at five sexually transmitted disease (STD) clinics to evaluate the efficacy of HIV counseling interventions in preventing HIV and other STDs. Because consistent and proper use of latex condoms is one method to substantially reduce the risk for transmitting HIV and other STDs (1), the HIV prevention interventions being evaluated focus primarily on increasing consistent condom use with primary and other sex partners during vaginal and anal sex. Before initiating the randomized trial, pilot studies were conducted to better characterize the population and to develop an operationally feasible enhanced intervention. This report describes the results of one pilot study.
Imipramine and social-vocational adjustment in chronic depression
Authors: J. H. Kocsis, A. J. Frances, C. Voss, B. J. Mason, J. J. Mann, J. Sweeney
Journal: American Journal of Psychiatry (1988)

The authors compared the effects of 6 weeks of imipramine treatment with 6 weeks of placebo treatment on social and vocational impairment in chronic depression. Imipramine was associated with significantly greater pre- to posttreatment improvement of social-vocational impairments in chronic depression, suggesting that these impairments may have represented affective symptoms rather than characterologic deficits.
l-lactate kinetics after abdominal aortic surgery and intestinal ischemia – An observational cohort study
Authors: Tomas Novotny, Robert Staffa, Josef Tomandl, Tomas Krivka, Ondrej Slaby, Lubos Kubicek, Ernest Biros, Marie Tomandlova, Robert Vlachovsky, Jan Sponiar, Lenka Radova, Anna Konieczna
Journal: International Journal of Surgery (2022)
Global health 2021: who tells the story?
Authors: None The Lancet Global Health
Journal: The Lancet Global Health (2021)

In an Art of Medicine essay published in The Lancet in November, 2020, Seye Abimbola and Madhukar Pai set out a vision for the future of academic global health. In their promised land they imagine, among other changes, a transformation of journals—"No longer exclusive, high-impact western journals now exist among a multitude of go-to places, most of which are now based in the Global South"—and imbalances in authorship within high-income country and low-income or middle-income country (LMIC) collaborations are "a thing of the past".
COVID-19, a pandemic or not?
Authors: None The Lancet Infectious Diseases
Journal: The Lancet Infectious Diseases (2020)

The current outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to spread, and as of March 11, 2020, it has reached 115 countries, with 119 239 cases and 4287 deaths. In January, WHO decided to define the outbreak of COVID-19 as a public health emergency of international concern, which triggered the release of funding and other resources. Despite SARS-CoV-2 now being present in every continent apart from Antartica, WHO remains reluctant to make the next step and call the outbreak a pandemic.
Effect of left ventricular outflow tract obstruction on hemodynamic adaptation to exercise in hypertrophic cardiomyopathy Quirino Ciampi, Sandro Betocchi, Anna Violante, Fiore Manganelli, Maria A. Losi, Giulia Sica, Carlo G. Tocchetti, Raffaella Lombardi, Elpidio Pezzella, Filippo Finizio, Alberto Cuocolo, Massimo Chiariello. Federico II University of Naples, Naples, Italy
Journal: Journal of the American College of Cardiology (2001)
Hypertension in Low- and Middle-Income Countries
Authors: Aletta E. Schutte, Nikhil Srinivasapura Venkateshmurthy, Sailesh Mohan, Dorairaj Prabhakaran
Journal: Circulation Research (2021)

In recent decades low- and middle-income countries (LMICs) have been witnessing a significant shift toward raised blood pressure; yet in LMICs, only 1 in 3 are aware of their hypertension status, and ≈8% have their blood pressure controlled. This rising burden widens the inequality gap, contributes to massive economic hardships of patients and carers, and increases costs to the health system, facing challenges such as low physician-to-patient ratios and lack of access to medicines. Established risk factors include unhealthy diet (high salt and low fruit and vegetable intake), physical inactivity, tobacco and alcohol use, and obesity. Emerging risk factors include pollution (air, water, noise, and light), urbanization, and a loss of green space. Risk factors that require further in-depth research are low birth weight and social and commercial determinants of health. Global actions include the HEARTS technical package and the push for universal health care. Promising research efforts highlight that successful interventions are feasible in LMICs. These include creation of health-promoting environments by introducing salt-reduction policies and sugar and alcohol tax; implementing cost-effective screening and simplified treatment protocols to mitigate treatment inertia; pooled procurement of low-cost single-pill combination therapy to improve adherence; increasing access to telehealth and mHealth (mobile health); and training health care staff, including community health workers, to strengthen team-based care. As the blood pressure trajectory continues creeping upward in LMICs, contextual research on effective, safe, and cost-effective interventions is urgent. New emergent risk factors require novel solutions. Lowering blood pressure in LMICs requires urgent global political and scientific priority and action.
Severe Acute Respiratory Syndrome (SARS) and Coronavirus Testing—United States, 2003
Journal: JAMA (2003)

CDC and the World Health Organization (WHO) are continuing to investigate the multicountry outbreak of severe acute respiratory syndrome (SARS). Infection with a novel coronavirus has been implicated as a possible cause of SARS. This report updates information on U.S. residents with SARS and summarizes the clinical histories of the five U.S. residents identified as of April 9, 2003, who have both suspected SARS and laboratory evidence of infection with a novel coronavirus.
Hyperactive mTOR Pathway Promotes Lymphoproliferation and Abnormal Differentiation in Human Autoimmune Lymphoproliferative Syndrome
Authors: Simon Voelkl, Anne Rensing-Ehl, Andrea Allgaeuer, Elisabeth Schreiner, Myriam Ricarda Lorenz, Jan Rohr, Christian Klemann, Ilka Fuchs, Volker Schuster, Andre von Bueren, Eleonora Gambineri, Kathrin Siepermann, Robin Kobbe, Peter Arkwright, Daniel Stachel, Markus Metzler, Klaus Schwarz, Anita Kremer, Carsten Speckmann, Stephan Ehl, Andreas Mackensen
Journal: Blood (2015)
High incidence of silent pulmonary embolism in patients with atrial fibrillation with right atrial spontaneous echo contrast Yoshinori Yasuoaka, Johji Naito, Taro Okazaki, Noriko Sakamoto, Ryu Shutta, Junichi Yoshida, Katsuji Hashimoto, Wakatomi Chin, Hideo Kusuoka, Michitoshi Inoue, Yukihiro Koretsune. Osaka National Hospital, Osaka, Japan
Journal: Journal of the American College of Cardiology (2001)
Incorrect Reporting of Funding in: New Screening Tool Reveals Genes Essential for Cancer Cells' Survival
Journal: JAMA (2008)

In Reply: In response to the comments by Drs Racine and Joyce, I recommend Beauchamp's trenchant assessment of market justice in his article "Public Health as Social Justice," 1 published more than 30 years ago.That this article remains pertinent today highlights the continuing effects of market justice on health and health care in our society.His rejoinder to critics of the use of the term market justice follows:Some might object strenuously to the marriage of the two terms 'market' and 'justice.'One theory of the market holds that it is a blind hand that rewards without regard to merit or individual effort.For this point of view, see: [Friedman 2 and Hayek 3 ] . . .But Irving Kristol 4 . . .argues that this is a minority view; most accept the marriage of the market ideal and the merits of individual effort and performance.I agree with this point of view-which is to say I see the dominant model of justice in America as a merger of the notions of meritarian and market norms.
Masthead
Authors: Vicente Arroyo, Ding-Shinn Chen, Nelson Fausto, Richard Green, Roberto Groszmann, West Haven, Ct Jake, Lian Bethesda, Anna L O T, Ann Arbor, Arthur Mccullough, Jean-Michel Pawlotsky, Janardan Reddy, Don Rockey, Clifford Durham, Charles Steer, Harvey Alter, Elwyn Bethesda, Neil Elias, Los Kaplowitz, Robert Angeles, Hepatology Brown, Hartmut Elsnvhere, Kevin Jaeschke, Darius Mullen, Adrian Reuben, Irwin Arias, Steven Schenker, Sun Antonio, Paul Berk, New York, Ny Montgomery Bissell, Sun Francisco, Gre Ory Bologna, Cristiane Hettinger, Editorial Rsistanl, Vikki Webster, Michael Abecassis, Paul Adams
Journal: Hepatology (2002)
Contents
Authors: P Burra, F Tacke, V Ratziu, S Zeuzem, B Sangro, P Angeli, Williams Roger, Marcellin Patrick, Fattovich Giovanna, L James, M Boyer, C Lazarus, S Picchio, S Nayagam, Q Anstee, R Darlay, S Cockell, M Meroni, O Govaere, D Tiniakos, A Burt, P Bedossa, J Palmer, Y.-L Liu, G Aithal, M Allison, H Yki- Järvinen, M Vacca, J.-F Dufour, P Invernizzi, D Prati, M Ekstedt, S Kechagias, S Francque, S Petta, E Bugianesi, K Clement, J Schattenberg, L Valenti, C Day, H Cordell, A Daly, M Sarkar, J Grab, J Dodge, E Gunderson, J Rubin, R Irani, M Cedars, N Terrault, A Stockdale, B Kreuels, M Henrion, E Giorgi, I Kyomuhangi, C De Martel, Y Hutin, A Geretti, D Alfaiate, S Clément, D Gomes, N Goossens, F Negro, E Verna, G Morelli, A Lok, J Lim, A Di Bisceglie, C Landis, P Kwo, M Hassan, M Manns, M Vainorius, L Akushevich, D Nelson, M Fried, K Reddy, V Kinast, A Plociennikowska, T Anggakusuma, D Bracht, R Todt, T Brown, Y Boldanova, Y Zhang, M Brüggemann, M Friesland, G Engelmann, R Vieyres, F Broering, M Vondran, B Heim, R Sitek, T Bartenschlager, E Pietschmann, C Corpechot, O Chazouillères, P Belnou, A Montano-Loza, A Mason, M Ebadi, D Eurich, S Chopra, D Jacob, C Schramm, M Sterneck, T Bruns, P Reuken, F Rauchfuss, D Roccarina, D Thorburn, A Gerussi, P Trivedi, G Hirschfield, P Mcdowell, F Nevens, O Boillot, A Bosch, E Giostra, F Conti, R Poupon, A Parés, A Reig, M Donato, F Malinverno, A Floreani, F Russo, N Cazzagon, X Verhelst, J Goet, M Harms, H Van Buuren, B Hansen, F Carrat, J Dumortier, Q Cai, D Huang, H Yu, Z Zhu, Z Xia, Y Su, Z Li, J Gou, J Qu, Y Sun, Q He, J Chen, L Liu, L Xu, J Lai, M Kappus, M Dunn, M Volk, A Duarte-Rojo, D Ganger, R Rahimi, C Mcculloch, C Haugen, M Mcadams, T Balzano, S Dadsetan, J Forteza, A Cabrera-Pastor, L Taoro-Gonzalez, M Malaguarnera, S Gil-Perotin, L Cubas-Nuñez, B Casanova, A Castro-Quintas, A Ponce-Mora, Y Arenas, P Leone, S Erceg, M Llansola, V Felipo, A Sangiovanni, E Alimenti, R Gattai, R Filomia, E Parente, L Marzi, G Pellegatta, G Borgia, M Gambato, N Terreni, I Serio, L Belli, F Oliveri, S Maimone, M Brunacci, R D'ambrosio, L Forzenigo, M Rumi, M Barone, A Fracanzani, G Raimondo, E Giannini, M Brunetto, E Villa, E Biganzoli, M Colombo, P Lampertico
Journal: Journal of Hepatology (2020)