tbuckley/cabot-search huggingface dataset:
PROFESSIONAL UNITY.
Journal: JAMA (1893)

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Abstract 17122: Cardioprotection With Proangiogenic Nanomaterials Formulated With CHIR99021 and FGF1
Authors: Chengming Fan, Yasin Oduk, Meng Zhao, Yawen Tang, Gregory P. Walcott, Jianyi Zhang, Wuqiang Zhu
Journal: Circulation (2018)

Introduction: We aimed at to investigate whether activation of both FGF1 and Wnt1 synergistically enhances angiogenesis and render the cardioprotection in hearts with post infarction LV remodeling. Materials and methods: CHIR99021 (a Wnt1 activator) and FGF1 were encapsulated into poly lactic-co-glycolic acid nanoparticles (CHIR99021/FGF1-NPs). Ischemic heart models were generated in C57BL/6 mice or Yorkshire swine by ligation of the left anterior descending coronary. The mice were randomly divided into 6 groups: Myocardial infarction (MI) Only (n=11), MI with nanoparticles (CHIR99021 or/and FGF1 loaded) injection (n=12, each), MI with non-loaded nanoparticles injection (n=11) and Sham group (n=10). The swine were divided into 3 groups: ischemic reperfusion injury (IRI) (n=4), IRI with CHIR99021/FGF-NPs injection (n=4) and Sham group (n=4). Left ventricle function 4 week after surgery were evaluated by Echocardiography. Cell proliferation was assessed via immunostaining in ischemic hearts and in cultivated human umbilical vein endothelial cells (HUVECs) and Human vascular smooth muscle cells (HVSMCs) using the following markers: Ki67, Brdu, PH3, and Aurora B. Apoptosis was determined with TUNEL staining. Cardiac fibrosis was evaluated via Sirius red and Fast green staining (mice) and magnetic resonance imaging (swine). Results: CHIR99021/FGF1-NPs treatment attenuated fibrosis and preserved heart contractile function in mice and swine models of postinfarction LV remodeling. The proportion of cells that expressed cell cycle markers (Ki67; BrdU; Aurora B and PH3) was significantly greater in CHIR99021+FGF1 treatment group than CHIR99021, FGF1 and PBS treatment group. The proportion of apoptotic cells was significantly smaller in CHIR99021+FGF1 treatment group than in groups of control, VEGF, CHIR99021, or FGF1 treatment alone. Conclusions: CHIR99021 and FGF synergistically activate cell cycle and reduce apoptosis, which accompanied by a significant improvement of cardiac function.
CHARACTERISTICS AND OUTCOMES OF PERCUTANEOUS REVASCULARIZATION OF UNPROTECTED LEFT MAIN CORONARY ARTERY STENOSIS IN THE UNITED STATES: RESULTS FROM THE NATIONAL CARDIOVASCULAR DATA REGISTRY, 2004-2008
Authors: J. Matthew Brennan, Pamela S. Douglas, David Dai, Kevin Anstrom, Ehrin J. Armstrong, John Messenger, Manesh Patel, Sunil Rao, Emily Honeycutt, Eric Eisenstein, Jeptha P. Curtis, Kendrick Shunk, William Weintraub, Eric D. Peterson, William Hillegass
Journal: Journal of the American College of Cardiology (2011)
Abstract 211: The Effect of Competitive Gamification on Self-Directed CPR Training Among Healthcare Professionals: A Multi-National Randomized-Control Study
Authors: Todd P Chang, Tia Raymond, Maya Dewan, Travis Whitfill, Ilana Harwayne-Gidansky, Cara B Doughty, Karin Frisell, David O Kessler, Heather Wolfe, Marc A Auerbach, Chrystal Rutledge, Ralph MacKinnon, Diana Mitchell, Priti Jani, Catharine M Walsh
Journal: Circulation (2018)

Background: Low-dose, high-frequency CPR training, such as the AHA Resuscitation Quality Improvement program, is designed to prevent skills decay. Preliminary studies have shown success in using gamification- namely a competitive leaderboard - for self-directed CPR training using a feedback-enabled CPR simulator. The purpose of this study was to determine the effect of a larger-scaled gamification system across multiple institutions on self-directed CPR practice frequency and resulting performance. Methods: This was a randomized-control study with 14 institutions. Subjects were healthcare professionals with unlimited access to a feedback-enabled CPR manikin. Subjects were asked to upload CPR scores and a ‘Selfie’ upon completion of any practice chest compressions. Each institution’s scores and photos were displayed on an online leaderboard for 4 months during the Intervention phase, and were denied access into the leaderboard for 4 additional months for the Control phase. The order of the phases was randomized per institution. Outcome variables included mean number of CPR episodes per person and mean CPR performance score measured by the simulator. Independent t-tests compared outcome variables between the 2 phases for unadjusted and adjusted results based on treatment and crossover effects. Results: A total of 919 subjects performed 1850 CPR episodes during the study period. Unadjusted mean CPR episodes per subject was higher in Control phase than the Intervention phase (2.9 +/- 7.2 vs. 1.6 +/- 1.7, p&lt;0.001). However, when controlling for a crossover effect, there was no difference in mean CPR episodes per subject between the Intervention (1.6 [95CI 1.4, 1.9]) and Control phase (1.7 [95CI 1.5, 2.0], p=0.6). No difference in mean CPR performance scores were found (90.7 [89.4, 92.0] vs 89.3 [87.6, 91.0], p=0.2). Conclusion: A competitive gamification system did not affect self-directed simulated CPR practice frequency or CPR performance.
TCT-797 Transcatheter Mitral Valve-in-Valve / Valve-in-Ring Implantations For Degenerative Post Surgical Valves: Results From The Global Valve-in-Valve Registry
Authors: Danny Dvir, John Webb, Ulrich Schäfer, Hendrik Treede, Sabine Bleiziffer, Azeem Latib, Claudia Fiorina, Josep Rodes-Cabau, Manuel Wilbring, Alfredo Cerillo, Fleur Descoutures, Victor Guetta, Arend de Weger, Raffi Bekeredjian, Amit Segev, Didier Tchetche, Rui Teles, Jian Ye, Helene Eltchaninoff, Ran Kornowski
Journal: Journal of the American College of Cardiology (2012)
Updated US Prevalence Estimates for Chronic Kidney Disease Stage and Complications Using the New Race-Free Equation to Estimate Glomerular Filtration Rate
Authors: Carl P. Walther, Wolfgang C. Winkelmayer, Sankar D. Navaneethan
Journal: JAMA Network Open (2022)

This cross-sectional study investigates US population changes in chronic kidney disease (CKD) G stage and 4 CKD-related complications, comparing the 2021 equation for estimating glomerular filtration rate with the 2009 equation, which included a race coefficient.
Genital herpes.
Authors: J K Oates
Journal: BMJ (1980)

serological tests were obtained in 69 of these patients.Of the remaining 31 patients, significant antibody titres to toxoplasma were obtained in five and to cytomegalovirus in two.In 24 patients the cause of the illness was undiagnosed.In our series the level of atypical lymphocy- tosis was critical: all 19 patients with atypical lymphocytes forming over 450°of the total leucocyte count gave a positive result in the Paul-Bunnell-Davidsohn test; and all 27 patients with over 40%0 of atypical lympho- cytes were either positive in the Paul- Bunnell-Davidsohn test or had significant titres of IgM anti-Epstein-Barr virus anti- bodies.Thus it appears that high levels of lymphocytes (over 40',) are diagnostic of infectious mononucleosis, whereas at lower levels of atypical lymphocytes an appreciable number of patients do not have infectious mononucleosis.
The association of the use of anxiety and depression medications with PSA testing.
Authors: Areeb Khan, Hanan Goldberg, Ruben Pinkhasov, Oleg Shapiro, Joseph M Jacob, Gennady Bratslavsky
Journal: Journal of Clinical Oncology (2022)

56 Background: Mental illness is a growing issue in the USA. More individuals continue to be diagnosed with illnesses such as depression and anxiety and placed on necessary medications. Studies have shown that the psychological makeup of an individual greatly impacts their health behavior and usage of preventative measures. However, there is limited research on the effect of anxiety and depression on PSA testing. This study explores the associations between the use of anxiety and depression medications and PSA testing. Methods: We used data from the National Health Interview Survey during the year 2018, and assessed responses to the question “Have you ever had a PSA test?” and “What is the number of PSA tests you had in the last 5 years?”. Responses were stratified by whether men were taking medications for anxiety, depression, both or none. We performed multivariable logistic regression analysis to define adjusted odds ratios of undergoing PSA testing adjusting for relevant socio-economic and demographic parameters. Results: Among the 5,035 male participants, 89.4% did not take any medication, 2.9% reported they took anxiety medication, 2.1% took depression medication and 5.5% took both medications. There was a significantly higher rate of PSA testing in men who took medications for both anxiety and depression compared to men taking no medications (p=0.002). Furthermore, the average number of PSA tests in the last 5 years was highest in the group of men taking both medications ( p &lt; 0.0001). Multivariable analysis showed that men who took medications for both depression and anxiety were more likely to undergo PSA testing in comparison to men, not on any of these medications (OR=1.755, p=0.001). The multivariable analysis also showed that age, living with a spouse, and prior cancer history were associated with an increased likelihood of PSA testing while being a minority, living in the south of the USA, and being a current smoker was associated with a lower likelihood of undergoing PSA testing. Conclusions: Taking both anxiety and depression medications in men may be associated with a higher likelihood of undergoing PSA testing. Despite obvious limitations of this analysis including its retrospective nature and recall bias, this association needs to be further explored, especially due to rising use of these medication in the current era of the COVID-19 pandemic.[Table: see text]
The Incidence of SARS-CoV-2 Reinfection in Persons With Naturally Acquired Immunity With and Without Subsequent Receipt of a Single Dose of BNT162b2 Vaccine
Authors: Sivan Gazit, Roei Shlezinger, Galit Perez, Roni Lotan, Asaf Peretz, Amir Ben-Tov, Esma Herzel, Hillel Alapi, Dani Cohen, Khitam Muhsen, Gabriel Chodick, Tal Patalon
Journal: Annals of Internal Medicine (2022)

There is insufficient evidence regarding the magnitude and durability of protection conferred by a combined effect of naturally acquired immunity after SARS-CoV-2 infection and vaccine-induced immunity.To compare the incidence rate of SARS-CoV-2 reinfection in previously infected persons to that of previously infected persons who subsequently received a single dose of BNT162b2 messenger RNA vaccine.A retrospective cohort study emulating a randomized controlled target trial through a series of nested trials.Nationally centralized database of Maccabi Healthcare Services, Israel.Persons with documented SARS-CoV-2 infection who did not receive subsequent SARS-CoV-2 vaccination were compared with persons with documented SARS-CoV-2 infection who received a single dose of the BNT162b2 vaccine at least 3 months after infection.Forty-one randomized controlled trials were emulated, in which 107 413 Maccabi Healthcare Services' members aged 16 years and older were eligible for at least 1 trial.SARS-CoV-2-related outcomes of infection, symptomatic disease, hospitalization, and death, between 2 March and 13 December 2021.A statistically significant decreased risk (hazard ratio, 0.18 [95% CI, 0.15 to 0.20]) for reinfection was found among persons who were previously infected and then vaccinated versus those who were previously infected but remained unvaccinated. In addition, there was a decreased risk for symptomatic disease (hazard ratio, 0.24 [CI, 0.20 to 0.29]) among previously infected and vaccinated persons compared with those who were not vaccinated after infection. No COVID-19-related mortality cases were found.Hybrid protection against non-Delta variants could not be inferred.Persons previously infected with SARS-CoV-2 gained additional protection against reinfection and COVID-19 from a subsequent single dose of the BNT162b2 vaccine. Nonetheless, even without a subsequent vaccination, reinfection appeared relatively rare.None.
Reply to G. Bi et al
Authors: Siddhartha Devarakonda, Ningying Wu, Sumithra Sankararaman, Ramaswamy Govindan
Journal: Journal of Clinical Oncology (2022)

We thank Bi et al 1 for their interest in and comments on our recent publication 2 which examined the genomic landscape of lung cancer in never-smokers.As pointed out, we observed significant differences between the composition of our never-smoker and smoker cohorts.Although such differences in cohort composition can introduce a selection bias in the reported findings, it is unlikely to have influenced the estimation of genomic aberrations between these cohorts in our study.As a matter of fact, in both studies 3,4 cited by Bi et al, 1 there is a high likelihood that the association between sex and the prevalence of EGFR and KRAS mutations was largely an effect of smoking status, given that lung cancer in neversmokers affects women disproportionately compared with men. 5 For instance, in the study by Zhao et al, 4 which observed a significantly higher frequency of EGFR mutations among women and KRAS mutations among men, 88.1% of the profiled 1,321 lung adenocarcinoma samples were collected from neversmokers and 62.1% of the samples from women.Nevertheless, implementing the suggestion offered by Bi et al, 1 we matched 117 never-smokers with smokers on a 1:1 basis using propensity scores that were based on age, sex, and predicted ancestry.The prevalence of mutations in EGFR and KRAS was then compared between these never-smoker and smoker cohorts consisting of propensity score matched samples, with the results faithfully reproducing our initial findings.EGFR mutations were significantly more frequent in tumors collected from neversmokers compared with smokers (48% v 4%; P , .0001), and KRAS mutations were more frequent among tumors collected from smokers compared with never-smokers (34% v 8%; P , .0001).As more never-smoker lung cancer tumor samples are sequenced in future studies and with the ready availability of next-generation sequencing assays in the clinic for identifying somatic and germline variants in several cancer-associated genes, it is likely that our understanding of the pathogenesis of this disease and how it differs from smoking-related lung cancer will evolve-with implications for screening and treatment in the years to come.
<i>Announcement</i>: World IBD Day — May 19, 2017
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

World IBD Day is recognized on May 19 to raise awareness of inflammatory bowel disease (IBD) and the two conditions that comprise it: Crohn's disease and ulcerative colitis, both of which cause chronic inflammation of the gastrointestinal tract. World IBD Day is sponsored by the European Federation of Crohn's and Ulcerative Colitis Associations, which includes the Crohn's & Colitis Foundation.
Error in Sensitivity and Specificity Estimates
Authors: Neena Modi, Cheryl Battersby, Bmedsci Longford
Journal: JAMA Pediatrics (2017)

Cheryl Battersby, MRCPCH; Nick Longford, PhD; Kate Costeloe, MD; Neena Modi, MD; for the UK Neonatal Collaborative Necrotising Enterocolitis Study Group
Racial differences in the natural history of small renal masses: A prospective registry study.
Authors: Joseph G. Cheaib, Sunil H. Patel, Ridwan Alam, Meredith Metcalf, Bruce Trock, Yuezhuo Jing, Yasser Ged, Mohamad Allaf, Phil Pierorazio, Nirmish Singla
Journal: Journal of Clinical Oncology (2022)

295 Background: Patients with small renal masses (SRM) can be managed conservatively by active surveillance (AS) or active treatment. A subset of patients who elect for AS undergo delayed intervention, either due to progression or other factors. Using a large, prospective registry of patients with SRMs we characterize differences in SRM growth trajectories on AS and pathologic differences among resected SRMs between African Americans (AA) and Caucasians. Methods: We stratified patients enrolled in the prospective Delayed Intervention and Surveillance for Small Renal Masses (DISSRM) registry by race. DISSRM includes AS, primary intervention (PI), and delayed intervention (DI). The growth rate for patients who elected for AS was compared between AA and Caucasian patients. Pathologic features among patients who underwent PI or DI were compared by race. Results: We enrolled 745 patients in DISSRM who were either AA (n = 117, 15.7%) or Caucasian (n = 628 (84.3%)), with median follow-up of 3.3 years [IQR 1.5-6.6]. 410 patients elected for AS (84% Caucasian, 16% AA) and 401 opted for PI (n = 335) or DI (n = 66) (86% Caucasian, 14% AA). Within the AS cohort, no differences were seen in age, comorbidities, or tumor size, though Caucasians were more male-predominant (60.9% vs. 38.5%, p = 0.001), and body mass index was higher among AA (p = 0.03). Median overall growth rate for AA vs Caucasian was 0.04 cm/year [-0.03-0.3] vs 0.1 cm/year [0-0.33], p = 0.2 (Figure).In the DI arm, median time to intervention was 12.5 months, with HR (AA vs Caucasian) being 0.32 (0.13-0.82), p = 0.02. There were no differences in baseline clinical characteristics or tumor size in the DI or PI arm, however AA were more likely to undergo radical nephrectomy (24.6% vs. 10.4%, p = 0.01). pT stage and grade were similar between groups, and papillary histology was more common among AA (34.1% vs 19.9%, p = 0.007). There were 31 deaths among patients undergoing intervention, which was significantly worse for AA after multivariable adjustment (HR 2.51, p = 0.025). Conclusions: Using the largest prospective registry of SRM, we found the natural history of SRM on AS to be similar between AA and Caucasians. However, histology, surgical approach, and survival differed between groups, with worse OS among AA. Further socioeconomic and molecular analyses will help elucidate biological differences and identify strategies to improve outcomes among patients with SRM.
BOOK REVIEWS
Authors: P. M. BUSSE
Journal: JNCI Journal of the National Cancer Institute (1988)

BOOK REVIEWS Get access Principles and Practice of Radiation Oncology. Carlos A. Perez, Luther W. Brady, eds. Philadelphia: Lippincott, 1987 1316 + xv pp. $140. PAUL M. BUSSE PAUL M. BUSSE Joint Center for Radiation Therapy, Harvard Medical School50 Binney St., Boston, MA 02115 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 10, 20 July 1988, Page 776, https://doi.org/10.1093/jnci/80.10.776 Published: 20 July 1988
Certification
Authors: J. Downes
Journal: BMJ (1963)

tion of the analytical technique used.7 Interested readers are referred to this article and two recent reviews.8 ' Finally I want to stress the statement of Goldberg and Rimington" that whenever an active case of acute intermittent porphyria is discovered it becomes a duty to test the urines of relatives for the presence of porphobilinogen; this test needs to be done with ion exchange chromatography and as far as possible determination of A.L.A. should be included (see ref. 7).-I am, etc., TORBEN K. WITH.
High SARS-CoV-2 seroprevalence among health care workers in Bamako referral hospitals: a prospective multisite cross-sectional study (ANRS COV11)
Authors: Almoustapha I. Maiga, Mahamadou Saliou, Amadou Kodio, Abdoulaye M. Traore, Garan Dabo, Philippe Flandre, Djeneba B. Fofana, Karim Ammour, Nanzie O.M.E. Tra, Oumar Dolo, Anne-Geneviève Marcelin, Eve Todesco
Journal: Clinical Microbiology and Infection (2022)
Widespread Misinformation About Infertility Continues to Create COVID-19 Vaccine Hesitancy
Authors: Jennifer Abbasi
Journal: JAMA (2022)

Daniel C. Gonzalez, BS; Daniel E. Nassau, MD; Kajal Khodamoradi, PhD; Emad Ibrahim, MD; Ruben Blachman-Braun, MD; Jesse Ory, MD; Ranjith Ramasamy, MD
Cyclosporin A Reveals Potent Antiviral Effects in Preclinical Models of SARS-CoV-2 Infection
Authors: Lucie Sauerhering, Irina Kuznetsova, Alexandra Kupke, Lars Meier, Sandro Halwe, Cornelius Rohde, Jörg Schmidt, Rory E. Morty, Olga Danov, Armin Braun, István Vadász, Stephan Becker, Susanne Herold
Journal: American Journal of Respiratory and Critical Care Medicine (2022)
Exosomes as a new frontier of cancer liquid biopsy
Authors: Dan Yu, Yixin Li, Maoye Wang, Jianmei Gu, Wenrong Xu, Hui Cai, Xinjian Fang, Xu Zhang
Journal: Molecular Cancer (2022)

Abstract Liquid biopsy, characterized by minimally invasive detection through biofluids such as blood, saliva, and urine, has emerged as a revolutionary strategy for cancer diagnosis and prognosis prediction. Exosomes are a subset of extracellular vesicles (EVs) that shuttle molecular cargoes from donor cells to recipient cells and play a crucial role in mediating intercellular communication. Increasing studies suggest that exosomes have a great promise to serve as novel biomarkers in liquid biopsy, since large quantities of exosomes are enriched in body fluids and are involved in numerous physiological and pathological processes. However, the further clinical application of exosomes has been greatly restrained by the lack of high-quality separation and component analysis methods. This review aims to provide a comprehensive overview on the conventional and novel technologies for exosome isolation, characterization and content detection. Additionally, the roles of exosomes serving as potential biomarkers in liquid biopsy for the diagnosis, treatment monitoring, and prognosis prediction of cancer are summarized. Finally, the prospects and challenges of applying exosome-based liquid biopsy to precision medicine are evaluated.
University College, London
Authors: N. Collie
Journal: BMJ (1904)

MADIAL JOU,N 885 daily work of preventing the ravages of disease, will often wonder that knowledge s0 important and 'so desirable is so difficult to attain.Our immediate perceptions do not carry us very far, but to investigate the facts and processes which lie beyond the reach of our immediate senses we can apply the experimental method.Patient investigation by this mnethod gradually adds to the sum of our knowledge.There is no ground forpessimism.We mustpass through theearlier stages before we reach the later ones.Many of the conclu-