tbuckley/cabot-search huggingface dataset:
Abstract 14043: Association of Non-Alcoholic Steatohepatitis Assessed by Fib-4 Index and Risk of Cardiovascular Disease: The Atherosclerosis Risk in Communities (ARIC) Study
Authors: Aliza Hussain, VIJAY NAMBI, Elizabeth Selvin, Wensheng Sun, Kunihiro Matsushita, Bing Yu, Eric Boerwinkle, Fasiha Kanwal, Pamela L Lutsey, Gerardo M HEISS, Ron C Hoogeveen, Christie M Ballantyne
Journal: Circulation (2020)

Introduction: Cardiovascular disease (CVD) is the most common cause of death in nonalcoholic steatohepatitis (NASH). While these conditions share many cardio-metabolic risk factors including metabolic syndrome, diabetes and dyslipidemia, limited data exist on whether NASH is independently and prospectively associated with incident CVD beyond traditional risk factors. Fibrosis-4 (FIB-4) index is a scoring system based on platelet count, age, AST and ALT, shown to be comparable to magnetic resolution elastography for predicting advanced fibrosis in biopsy-proven NASH. We sought to evaluate the association of elevated FIB-4 with global CVD events and CVD mortality in the Atherosclerosis Risk in Communities (ARIC) Study Methods: We studied 5531 individuals, mean age of 76 (SD 5.2) years, 58% female, 22% black, at ARIC visit 5 (2011-2013). FIB-4 was categorized as low risk of advanced fibrosis for score &lt;1.45, intermediate for 1.45-3.25 and high for &gt;3.25. Cox regression was used to estimate the association of FIB-4 with time to first global CVD event (CHD, ischemic stroke or heart failure hospitalization) and CVD mortality adjusted for pooled cohort equation risk factors. Results: Over a median follow up of 6.2 (5.3-6.8) years, there were 1108 global CVD events and 457 CVD deaths. In adjusted models, compared to participants with low FIB-4 (&lt;1.45), those with elevated FIB-4 &gt;3.25, had significantly increased risk for global CVD events (HR 1.58, 95% CI 1.23-2.02) and CVD mortality (HR 1.70, 95% CI 1.16-2.50). Conclusions: In a large prospective cohort, presence of advanced liver fibrosis, as assessed by elevated FIB-4 index &gt;3.25, was associated with increased risk for CVD events and CVD mortality, beyond traditional CVD risk factors. Future clinical trials of candidate medications under study for NASH should examine whether effective NASH treatment will impact CV outcomes.
リポ蛋白質(a)は急性心筋梗塞患者において冠動脈プラーク形状を測定するための重要な因子である
Authors: Hikita Hiroyuki, Kuroda Shunsuke, Satoh Akira, Nagai Nao, Kawaguchi Naohiko, Nakashima Emiko, Fujinami Tatsuya, Kusa Shigeki, Kamiishi Tetsuo, Ohkubo Kenji, Fujino Tadashi, Takahashi Yoshihide, Nozato Toshihiro, Kuwahara Taishi, Takahashi Atsushi, Isobe Mitsuaki
Journal: Circulation (2011)
Abstract 14888: Extracellular Matrix Quantification of Fully Regenerated Neochorade After Bio-scaffold Mitral Valve Implantation in a Juvenile Non-human Primate Model
Authors: Brittany A Gonzalez, Marcos Gonzalez Perez, Asad Mirza, Frank Scholl, Steven Bibevski, Krishna Rivas Wagner, Jennifer bibevski, Lazaro E Hernandez, Elena Ladich, vincent brehier, Miguel Casares, Pablo Morales, Jesus Lopez, Joseph Wagner, Sharan Ramaswamy
Journal: Circulation (2020)

Introduction: To investigate enhanced treatment options for critical mitral valve disease in children, we implanted a bio-scaffold mitral valve comprising of porcine small intestinal submucosa (PSIS) in a juvenile baboon model. Hypothesis: New tissue formation would be accelerated at physical connections between the replacement bio-scaffold valve and native cardiac tissues, due to direct extracellular matrix (ECM) communications. Methods: Juvenile baboons (n=2) were implanted with a hand-made bicuspid PSIS (Cormatrix, Roswell, GA) mitral valve. The PSIS valves were excised at 11- and 20-months post-implantation. Images of histological stains (Movat’s Pentachrome; Alizée Pathology, Inc., Thurmont, MD) were subsequently spatially mapped for ECM quantification (MATLAB; Mathworks, Natick, MA). Results: PSIS bio-scaffold mitral valves (11- and 20-months post-implantation) facilitated complete regeneration of neochordae. The neochordae seamlessly integrated into the papillary muscles and left ventricular insertion sites ( Figure 1A, E ). We also found that with an increase in implantation duration of ~ 9 months, the collagen, proteoglycan and elastin content (per mm 2 ; Figure 1B-D, F-H ) had a fold-change of 6.96, 18.42 and 4.94, respectively. Conclusions: Our findings suggest that the PSIS bio-scaffold mitral valve apparatus can regenerate neochordae without the need for any biochemical or biomechanical treatment. Nonetheless, other valve spatial areas of importance (e.g. leaflets) will require additional strategies. As a next step, we will produce oscillatory flow-conditioned, stem cell-derived ECM, to accelerate tissue regeneration. The mechanical parameters that we computed to permit physiological oscillatory flow conditions are an oscillatory shear index (OSI) of 0.23 and time averaged bio-scaffold shear stress (TAB-SSS) of 4.6 dynes/cm 2 . Acknowledgements: AHA Award ID: 16GRNT31090009; The Miami Research Heart Institute; FIU-UGS DYF.
구연 : 위 정맥류 출혈에 대한 Histoacryl(R) 치료 효과 및 재출혈 요인
Authors: 김선문, 박기오, 문희석, 이엄석, 이병석, 김남재, 이헌영
Journal: Clinical and Molecular Hepatology (2003)

배경/목적: 위 정맥류 출혈은 간 경변증의 중한 합병증으로 식도 정맥류 출혈에 비하여 빈도수는 적으나 출혈 시 혈류량이 많아 사망률이 매우 높으며 일차적인 내시경 치료로 Histoacryl(R) 주입법, 내시경적 경화요법, 금속 분리형 올가미 결찰요법과 고농도 식염수 주입법 등이 이용되고 있다. 그 중 Histoacryl(R) 주입법은 세계적으로 널리 이용되고 있으며, 다른 방법에 비해 합병증이 적고 지혈 효과가 좋다고 보고되고 있는 바 저자들은 위 정맥류 출혈에서 Histoacryl(R)을 이용한 경화요법 후 치료효과와 재 출혈 환자에서 출혈에 대한 인자를 알아보고자 하였다. 대상과 방법: 1998년 12월부터 2003년 2월 까지 출혈을 주소로 내원하여 내시경으로 위 정맥류 출혈로 진단을 하고 Histoacryl(R) 치료를 시행받은 61명 대상으로 평균 7.4 (범위:1-48개월)개월 동안 추적 관찰한 결과를 후향적으로 분석하였다. Histoacryl(R) 주사는 포도당액과 혼합하여(1:1) 주입하고, 지혈의 정도를 평가하여 반복 주입하였다. 결과: 환자의 평균 연령은 56세 이었고, 남자는 49명, 여자는 12명이었다. 위 정맥류의 원인 질환으로는 알콜성 간경변증 31명, B형 간염 바이러스에 의한 간경변증 21명, C형 간염 바이러스에 의한 경우 3명, 알코올과 B형 간염 바이러스에 의한 간경변증 1명, 알코올과 C형 간염 바이러스에 의한 간경변증 1명, 기타 4명이었고 간 세포암은 12명, 간 문맥 혈전은 3명에서 동반되었다. Child-pugh 분류로는 A 11명, B 29명, C 21명이었다. 내시경 소견에서 활동성 출혈은 13명, 최근에 출혈한 흔적은 48명에서 있었고, 56명에서 식도의 정맥류가 동반되었으며, 그 중 분문부 40명, 저부 13명, 분문부와 위저부에 위치한 경우가 3명이었다. 형태상 F1 1명, F2 46명, F3 13명이었고, Histoacryl(R) 평균 주입량은 2.6 cc 였으며, 식도 정맥류에 대해 내시경적 결찰술을 동시에 시행한 경우가 7예 있었다. 1주일 이내의 지혈 성공률은 61명중 58명(95%)이었고, 1주일에서 1개월 이내의 재출혈은 1명(1.6%), 1개월에서 3개월 이내의 재출혈 8명(13.5%), 3개월 이후 재출혈은 3명(4.9%)에서 있었다. 추적 관찰 중에 47명이 생존을 하였고, 14명이 사망을 하였으며 재출혈에 의한 사망은 그 중 2명이었고 다른 원인은 간부전, 뇌증, 괴사성 근막염에 의한 패혈증, 다른 병의 진행 등이 있었다. 합병증은 흉통 7명(12%), 발열 7명(12%)이었고, 그 외 중한 전신적 합병증은 없었다. 재 출혈은 간경변증의 원인과 간세포암이 동반 여부에 따라 통계학적으로 의미있는 차이가 있었으며, 성별, 나이, 정맥류의 형태, 간 문맥 혈전의 동반여부, Child-pugh 분류, 약물치료의 동시 사용여부와는 관련이 없었다. 결론: Histoacryl(R) 경화요법은 위정맥류 출혈 환자에서 조기 지혈을 포함한 성공율이 높으며 심한 합병증 없이 일차적으로 사용할 수 있는 치료법으로 생각한다. Histoacryl(R) 주입 후 재출혈의 요인은 위 정맥류의 원인과 간 세포암의 동반여부가 통계학적으로 의미가 있었다.
Abstract 056: Alcohol Increases Risk Of Cardiovascular Disease At All Levels Of Intake
Authors: Kiran J Biddinger, Connor Emdin, Mary E Haas, Minxian Wang, George Hindy, Patrick T Ellinor, Sekar Kathiresan, Amit V Khera, Krishna Aragam
Journal: Circulation (2021)

Genetic analyses have suggested a causal association between alcohol intake and cardiovascular diseases, questioning the purported cardioprotective effects of modest intake. Though traditional approaches to genetic epidemiology are limited in ability to assess association shapes, we hypothesized that any alcohol may increase risk of cardiovascular disease. In 371,463 participants from the UK Biobank, we first examined for confounding in epidemiological associations between alcohol intake and cardiovascular diseases. Next, using traditional and non-linear genetic approaches (Mendelian randomization), we assessed for causal links of alcohol consumption with several cardiovascular diseases and evaluated the shapes of all causal associations identified. Study participants consumed 9.2 (SD, 10.6) standard drinks per week on average; 121,708 (32.8%) and 27,667 (7.5%) subjects had hypertension and CAD, respectively. Modest consumers of alcohol demonstrated healthier lifestyles - such as lower BMI and greater physical activity - than abstainers, and adjustment for lifestyle factors attenuated the observed benefits of light alcohol intake. Traditional and non-linear Mendelian randomization demonstrated consistently risk-increasing and quadratic associations between alcohol consumption and both clinical and subclinical cardiovascular disease, with exponential increases in risk across levels of drinking; relative to abstainers, consumption of 7, 14, 21, and 28 drinks per week conferred 1.2, 1.7, 3.4, and 8.9-fold odds of hypertension and 1.2, 2.3, 6.2, and 25.9-fold odds of CAD, respectively (both models p&lt;0.001). In conclusion, coincident, favorable lifestyle factors may mediate the observational benefits of modest alcohol intake. All amounts of alcohol intake increase cardiovascular risk, but marked absolute and relative risk differences exist across levels of intake, which should inform public health recommendations around habitual alcohol consumption.
The atypical antipsychotic risperidone targets hypothalamic melanocortin 4 receptors to cause weight gain
Authors: Li Li, Eun-Seon Yoo, Xiujuan Li, Steven C. Wyler, Xiameng Chen, Rong Wan, Amanda G. Arnold, Shari G. Birnbaum, Lin Jia, Jong-Woo Sohn, Chen Liu
Journal: The Journal of Experimental Medicine (2021)

Atypical antipsychotics such as risperidone cause drug-induced metabolic syndrome. However, the underlying mechanisms remain largely unknown. Here, we report a new mouse model that reliably reproduces risperidone-induced weight gain, adiposity, and glucose intolerance. We found that risperidone treatment acutely altered energy balance in C57BL/6 mice and that hyperphagia accounted for most of the weight gain. Transcriptomic analyses in the hypothalamus of risperidone-fed mice revealed that risperidone treatment reduced the expression of Mc4r. Furthermore, Mc4r in Sim1 neurons was necessary for risperidone-induced hyperphagia and weight gain. Moreover, we found that the same pathway underlies the obesogenic effect of olanzapine—another commonly prescribed antipsychotic drug. Remarkably, whole-cell patch-clamp recording demonstrated that risperidone acutely inhibited the activity of hypothalamic Mc4r neurons via the opening of a postsynaptic potassium conductance. Finally, we showed that treatment with setmelanotide, an MC4R-specific agonist, mitigated hyperphagia and obesity in both risperidone- and olanzapine-fed mice.
Abstract 17007: Cardiac Magnetic Resonance Assessment of Right Ventricular Remodeling After Anthracycline Therapy
Authors: Thiago Ferreira de Souza, Thiago Quinaglia, Ligia Antunes-Correa, Zsofia Drobni, Felipe Costa, Wilson Nadruz, Fabrício Brenelli, Andrei Sposito, José Mattos-Souza, Tomas Neilan, Michael Jerosch-Herold, Otavio R Coelho-filho
Journal: Circulation (2020)

Introduction: There are limited data characterizing the effect of anthracyclines on right ventricular (RV) structure and function. Hypothesis: The goal of this study was to test the effect of anthracyclines on RV myocardial remodeling using cardiac magnetic resonance (CMR). Methods: This was a prospective CMR and serum biomarker study of 27 women with breast cancer (BC) (51.8±8.9 years) who underwent a CMR prior, and up to 3-times after anthracycline therapy (240 mg/m 2 ). The primary measure of interest was the RV extracellular volume (ECV) and cardiomyocyte mass index (1-ECV). Additional measures of interest were the left ventricular (LV) ECV, and the LV and RV mass. Biomarkers included high-sensitive troponin T, and creatinine-kinase MB isoenzyme (CKMB). Results: Before anthracyclines, all subjects had normal LV ejection fraction (EF) (69.4±3.6%) and RVEF (55.6±9%). At 351-700 days after anthracyclines, the LVEF and LV mass index declined to 58±6% (P&lt;0.001) and 36±6g/m 2 (P&lt;0.001). Similarly, the RVEF and RV mass index also decreased, reaching 46.3±6.8% at (222-350] days (P&lt;0.001) and 8.13±2g/m 2 at (350-700] days (P&lt;0.001) after anthracycline, respectively (Figure 1). At (350-700] days after anthracycline, both LV and RV ECV increased by 0.037 to 0.36±0.04 (P=0.004) and by 0.12 to 0.40±0.07 (P&lt;0.001), respectively (Figure 2). In parallel, both the LV and RV cardiomyocyte mass also decreased after anthracyclines (Figure 2). Conclusions: In a prospective observational study among women with breast cancer, anthracyclines were associated with a decrease in the RV EF, an increase in the RV ECV and a decrease in the RV cardiomyocyte mass.
Abstract P217: Associations Of Adipokine Levels With The Prevalence And Extent Of Valvular And Thoracic Aortic Calcification: The Multi-ethnic Study Of Atherosclerosis
Authors: Ty Sweeney, Oluseye Ogunmoroti, Chiadi E Ndumele, Di Zhao, Bhavya Varma, Matthew A Allison, Matthew Budoff, Oluwaseun E Fashanu, Apurva Sharma, Alain G Bertoni, Erin Michos
Journal: Circulation (2021)

Introduction: Extra-coronary calcification (ECC), a marker of systemic atherosclerosis, is an independent risk factor for incident cardiovascular disease (CVD). Adipokines participate in many cardiometabolic pathways and may mediate the effect of obesity on atherosclerosis. However, the relationship of adipokines with ECC is not well established. We hypothesized that higher leptin and resistin levels and lower adiponectin levels would be associated with a greater extent of ECC. Methods: We performed a cross-sectional analysis of 1,955 community dwelling adults free of clinical CVD in the MESA cohort. Serum adipokine levels and a cardiac CT scan were obtained at exam 2 or 3 (randomly assigned). ECC was quantified by Agatston score and included calcification of the mitral annulus (MAC), aortic valve (AVC), ascending thoracic aorta (ATAC) and descending thoracic aorta (DTAC). We used multivariable regression to evaluate the associations between leptin, resistin and adiponectin (per 1 SD of log transformed adipokine) with the prevalence and extent of ECC. Results: The mean age of participants was 62±10 years; 50% were women, 40% white, 13% Chinese, 21% Black and 26% Hispanic. In a model adjusted for demographics, we found 1) adiponectin was inversely associated with AVC prevalence and extent; 2) leptin was positively associated with MAC prevalence and extent; and 3) resistin was positively associated with ATAC prevalence and extent and with DTAC prevalence. After full adjustment for BMI and other CVD risk factors ( Table ), adiponectin remained inversely associated with AVC prevalence, and resistin remained associated with greater ATAC prevalence and extent. Leptin was not associated with measures of ECC after full adjustment. No adipokine was associated with MAC or DTAC after full adjustment. Conclusion: In this diverse cohort free from clinical CVD, we found significant associations between selected adipokines and specific markers of ECC. Adipokines may play a role in the development of systemic atherosclerosis.
Possibilities of Magnetic Resonance Imaging in the Diagnosis of Changes in the «Vascular Wall» in Giant Cell Arteritis
Authors: T. A. Lesnykh, M. A. Kravchenko, R. N. Konovalov, M. V. Dreval', M. V. Krotenkova, A. O. Chechetkin, L. A. Kalashnikova, L. A. Dobrynina
Journal: Radiology - Practice (2021)

The aim of the study: to identify features of extracranial carotid and vertebral arteries vessel wall MRI in norm and pathology using layer-by-layer analysis of the arterial wall components. MRI results were compared at the same anatomical level with data of ultrasound examination of vertebral arteries in patients with giant cell arteritis and in health individuals. It was revealed that in normal arteries MRI signal from the vessel wall mainly formed by vascularized adventitia and venous plexuses. Media and intima visualization becomes possible in cases of their pathological transformation. Thus, it was defined which structures of the vessel wall take part in MRI signal forming in health individuals and patient with pathology. Also MRI patterns of different stages of large arteries vasculitis were identified.
Measurable residual disease status and outcome of transplant in acute myeloid leukemia in second complete remission: a study by the acute leukemia working party of the EBMT
Authors: Maria H. Gilleece, Avichai Shimoni, Myriam Labopin, Stephen Robinson, Dietrich Beelen, Gerard Socié, Ali Unal, Arnold Ganser, Antonin Vitek, Henrik Sengeloev, Ibrahim Yakoub-Agha, Eleni Tholouli, Emmanuelle Polge, Mohamad Mohty, Arnon Nagler
Journal: Blood Cancer Journal (2021)

Abstract Measurable residual disease (MRD) prior to hematopoietic cell transplant (HCT) for acute myeloid leukemia (AML) in first complete morphological remission (CR1) is an independent predictor of outcome, but few studies address CR2. This analysis by the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation registry assessed HCT outcomes by declared MRD status in a cohort of 1042 adult patients with AML CR2 at HCT. Patients were transplanted 2006–2016 from human leukocyte antigen (HLA) matched siblings ( n = 719) or HLA 10/10 matched unrelated donors ( n = 293). Conditioning was myeloablative ( n = 610) or reduced-intensity ( n = 432) and 566 patients (54%) had in-vivo T cell depletion. At HCT, 749 patients (72%) were MRD negative (MRD NEG) and 293 (28%) were MRD positive (MRD POS). Time from diagnosis to HCT was longer in MRD NEG than MRD POS patients (18 vs. 16 months ( P &lt; 0.001). Two-year relapse rates were 24% (95% CI, 21–28) and 40% (95% CI, 34–46) in MRD NEG and MRD POS groups ( P &lt; 0.001), respectively. Leukemia-free survival (LFS) was 57% (53–61) and 46% (40–52%), respectively ( P = 0.001), but there was no difference in terms of overall survival. Prognostic factors for relapse and LFS were MRD NEG status, good risk cytogenetics, and longer time from diagnosis to HCT. In-vivo T cell depletion predicted relapse.
Abstract 13304: Liver Dispersion Predicts Adverse Outcomes in Patients With Heart Failure
Authors: Yu Hotsuki, Akiomi Yoshihisa, Koichiro Watanabe, Yu Sato, Yusuke Kimishima, Tetsuro Yokokawa, Tomofumi Misaka, Masayoshi Oikawa, Atsushi Kobayashi, Yasuchika Takeishi
Journal: Circulation (2020)

Background: It has been recently reported that liver stiffness assessed by transient elastography reflects right atrial pressure (RAP), and is associated with worse outcome in patients with heart failure (HF). However, the relationship between liver dispersion (LD, a novel indicator of liver viscosity) determined by abdominal ultrasonography and RAP, and prognostic impacts of LD on HF patients have not been fully examined. We aimed to clarify associations of LD with parameters of liver functional test (LFT) and right-heart catheterization (RHC), and cardiac event such as cardiac death and worsening HF in patients with HF. Methods and Results: We performed abdominal ultrasonography, LFT, RHC, and followed up cardiac events including cardiac death and unplanned hospitalization due to HF in patients with HF (n=157). We examined associations of LD with parameters of LFT and RHC. There were significant correlations between LD and circulating levels of gamma-glutamyl transferase (R=0.197, P=0.018), cholinesterase (R=-0.301, P=0.001), and 7S domain of collagen type IV (P4NP 7S, a marker of fibrosis, R=0.334, P&lt;0.001), but not with RAP (R=0.067, P=0.514) or cardiac index (R=-0.038, P=0.667). During the follow up period (median 305 days), 6 cardiac deaths and 18 unplanned hospitalization due to HF occurred. In the Kaplan-Meier analysis ( Figure ), cardiac event rate was significantly higher in the high LD group (LD ≥10.0 (m/s)/kHz, n=79) than in the low LD group (LD &lt; 10.0 (m/s)/kHz, n=78; log-rank, P=0.007). In the multivariable Cox proportional hazard analysis, high LD was found to be an independent predictor of cardiac event (hazard ratio 3.274, 95% confidence interval 1.203-8.912, P=0.020). Conclusions: LD assessed by abdominal ultrasonography reflects liver fibrosis rather than liver congestion, and is associated with adverse prognosis in HF patients.
Response to: ‘Correspondence on ‘Warfarin use and risk of knee and hip replacements’’ by Cheng and Zhang
Authors: Tuhina Neogi, Christine Peloquin, Priyanka Ballal, Cindy Germaine Boer
Journal: Annals of the Rheumatic Diseases (2021)

Response to: 'Correspondence on 'Warfarin use and risk of
Response to Comment on Rhee et al. Association Between Glycemic Status and the Risk of Parkinson Disease: A Nationwide Population-Based Study. Diabetes Care 2020;43:2169–2175
Authors: Sang Youl Rhee, Won-Young Lee
Journal: Diabetes Care (2020)

We would like to thank Melgoza et al. (1) for their interest in our article (2) and for suggesting the need for more analysis of the relationship of smoking and Parkinson disease (PD). They also suggested the importance of the cholinergic system in protection from PD and also stressed the need for discovery of novel drugs that target the cholinergic …
A Next-Generation Rapid, Accurate SARS-CoV-2 Antibody Test
Authors: Jennifer Abbasi
Journal: JAMA (2021)

More than a year into the COVID-19 pandemic, SARS-CoV-2 antibody tests are plentiful, but highly accurate, affordable, point-of-care versions with quantitative data still don't exist. An innovative test from scientists at the University of California, San Francisco, and colleagues could change that.
Abstract P180: Hospital Readmission After Pediatric Congenital Heart Surgery: A Systematic Review And Meta-analysis Of Potential Risk Factors
Authors: Meagan E Stabler, Devin M Parker, Sarina Kothari, Mahalia Dalmage, Heather Johnson, Madeleine Morgan, Jeremiah R Brown
Journal: Circulation (2021)

Objective: Over 40,000 infants are born annually with a heart defect; 25% require surgery and of those 20% result in hospital readmissions. We sought to identify risk factors for short- and long-term readmission following pediatric congenital heart surgery (CHS) to reduce avoidable future admissions. Methods: A systematic approach was used to search four electronic databases and retrieve articles published through 05/2020. We included observational and experimental studies that observed factors associated with 30-day or 1-year readmission after CHS. Studies with a composite outcome of readmission and death were excluded. For each independent risk factor, we assessed the pooled effect size and heterogeneity using a random-effects model. Risk of bias was assessed via the Newcastle-Ottawa scale. Results: After removing 970 duplicates, we screened 5,084 studies; 17 were included in the systematic review and 15 (N= 82,794; 9,856 readmitted) in the meta-analysis. Hospital readmission was significantly and positively associated with gestational age, non-white race, Hispanic ethnicity, government insurance, genetic abnormality, renal dysfunction, failure to thrive, mechanical ventilation, intraoperative ventricular dysfunction, RACHS score, STAT mortality score, cross clamp time, gastroesophageal reflux disease, postoperative arrhythmia, valve regurgitation, feeding difficulties, and ICU and hospital length of stay (LOS). Readmission definition (i.e., 1-yr vs 30-day) and LOS dichotomization (i.e., ≥ 10 or ≥ 14) resulted in significant subgroup differences for age at surgery and LOS. Five studies had higher potential for risk of bias. Conclusions: This is the first meta-analysis to identify patient and clinical factors associated with short and long-term readmission after pediatric CHS. Findings may support clinical decisions before undergoing surgery and identify patients that may benefit from receiving more aggressive care transitions prior to discharge to reduce avoidable hospital readmissions.