tbuckley/cabot-search huggingface dataset:
COUNCIL ON DRUGS
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial Board
Authors: Donald Leung, Stanley Szefler, Colo Associate, Andrea Apter, Pedro Philadelphia, Joshua Avila, Boston Boyce, Robert Bush, Fred Finkelman, Cincinnati Ohio, Dennis Ledford, Tampa Fla, Deborah Meyers, Luigi Notarangelo, David Peden, Chapel Hill, Harald Renz, Marburg Germany, Marc Rothenberg, Hirohisa Saito, William Shearer, Scott Sicherer, New York, Erika Von Mutius, Statistics Editor, Vernon Chinchilli
Journal: Journal of Allergy and Clinical Immunology (2013)
Dual CRISPR interference and activation for targeted reactivation of X-linked endogenous FOXP3 in human breast cancer cells
Authors: Xuelian Cui, Chao Zhang, Zhifang Xu, Shuaibin Wang, Xin Li, Erica Stringer-Reasor, Sejong Bae, Leiping Zeng, Dehua Zhao, Runhua Liu, Lei S. Qi, Lizhong Wang
Journal: Molecular Cancer (2022)

Abstract Background Unlike autosomal tumor suppressors, X-linked tumor suppressors can be inactivated by a single hit due to X-chromosome inactivation (XCI). Here, we argue that targeted reactivation of the non-mutated allele from XCI offers a potential therapy for female breast cancers. Methods Towards this goal, we developed a dual CRISPR interference and activation (CRISPRi/a) approach for simultaneously silencing and reactivating multiple X-linked genes using two orthogonal, nuclease-deficient CRISPR/Cas9 (dCas9) proteins. Results Using Streptococcus pyogenes dCas9-KRAB for silencing XIST and Staphylococcus aureus dCas9-VPR for activating FOXP3 , we achieved CRISPR activation of FOXP3 in various cell lines of human female breast cancers. In human breast cancer HCC202 cells, which express a synonymous heterozygous mutation in the coding region of FOXP3 , simultaneous silencing of XIST from XCI led to enhanced and prolonged FOXP3 activation. Also, reactivation of endogenous FOXP3 in breast cancer cells by CRISPRi/a inhibited tumor growth in vitro and in vivo . We further optimized CRISPRa by fusing dCas9 to the demethylase TET1 and observed enhanced FOXP3 activation. Analysis of the conserved CpG-rich region of FOXP3 intron 1 confirmed that CRISPRi/a-mediated simultaneous FOXP3 activation and XIST silencing were accompanied by elevated H4 acetylation, including H4K5ac, H4K8ac, and H4K16ac, and H3K4me3 and lower DNA methylation. This indicates that CRISPRi/a targeting to XIST and FOXP3 loci alters their transcription and their nearby epigenetic modifications. Conclusions The simultaneous activation and repression of the X-linked, endogenous FOXP3 and XIST from XCI offers a useful research tool and a potential therapeutic for female breast cancers.
SARS-CoV-2 Infections in Close Contacts of Positive Cases in the Olympic and Paralympic Village at the 2021 Tokyo Olympic and Paralympic Games
Authors: Hidechika Akashi, Satoshi Shimada, Toyomitsu Tamura, Eiki Chinda, Norihiro Kokudo
Journal: JAMA (2022)

Yang Ge, MS; Leonardo Martinez, PhD; Shengzhi Sun, PhD; Zhiping Chen, MD; Feng Zhang, MS; Fangyu Li, MS; Wanwan Sun, MD; Enfu Chen, MD; Jinren Pan, MD; Changwei Li, PhD; Jimin Sun, MD; Andreas Handel, PhD; Feng Ling, MD; Ye Shen, PhD
Instruction Course Table of Contents
Authors: Melvin Rubin, Ronald Fishman, John Glotfelty, Thomas Hanscom, Malcolm Luxenberg, D Jones, Laib Son, M Goldberg, W Harris, A Maumenee, C Roberts, W Stern, G Stern, H Taylor, A Scott, Von Noorden, Mandell General, M Shields, R Stewart, R Lewis, R 767 Wilensky, Magar Gal, M Boniuk, Flynn Glaucoma, O Connor, M Smith, R Wilson, Lawrie Ernest, Asbell Frederick, Boyd Goldberg, H 537 Curtin, Gager Kambara, Gammon Keeney, Garcia Mainster, Gruber Meltzer, Guyton Mills, Halberg Purnell, Hartstein Rav, Stenson Wilson, L Wilson, Allen Brown, Alper Burde, Anderson Burde, Baylis Cogan, Baylis Costin, Beale Fishman, Beyer Frenkel, Bosniak Hedges, Brindley Hedges, Bullock Hedges, Callahan Hoyt, Chandler Hyman, Coles Hyman, Della Rocca, Flanagan Kay, Freeman Kennerdell, Garber Klinge Le 540 Harris, G Lesser, Hecht Mills, ' Connor, P 585 Holt, Iliff Sacks, Katowitz Savino, Katzen Savino, Kennerdell Savino, Levine Smith, Mclachlan Thompson, Milder Wilson, Millett Wilson, Malbran Wobig, Margolis Wright, Mc Mee, Mcpherson Abrams, Mcpherson Allen, Meredith Berrocal, Meredith Bloome, Michels Blumenkranz, Morse Brinkley, Nelson Brockhurst, Malley O', Ober Buzney, Ogden Byer, Orth Cantrill, Ossoinig Carr, Packer Carr, Pavan Carroll, Rabb Charles, Rabb Chenoweth, Reeser Coleman, Rosenthal Coleman, Ruiz Conway, Ryan Cunha-Vaz, Sabates Cunha-Vaz, Sabates Daily, Schatz Davis, Tasman Fernan, Tolentino Fine, J Friedman, Weingeist Friedman, Weinstein Fung, Winslow Gass, Yannuzzi Goldbaum, Baylis Barber, Casey Byron, Easterbrook Chenoweth, James Katowitz, Richard Carroll, Richard Dortzbach, Francis Lapiana, Steven Kramer, John Stanley, Jorge Alvarado, John Lynn, Ralph Crump, Richard Eiferman, Norman Felberg, Malcolm Mazow, Tx Keith, David Apple, L Lohr-Pjace, John Cowden, Frederic Kremer, John Reed, Alan Roth, Mark Mainnis
Journal: Ophthalmology (1983)
P128: ITHANET: AN INFORMATION AND DATABASE COMMUNITY PORTAL FOR HAEMOGLOBINOPATHIES
Authors: A Minaidou, C Stephanou, S Tamana, M Xenophontos, C Lederer, P Kountouris, M Kleanthous
Journal: HemaSphere (2022)

Background: The ITHANET Portal (www.ithanet.eu) is an expanding, publicly available biomedical resource dedicated to haemoglobinopathies. It provides a manually curated, literature-derived collection of published genetic and epidemiological data, also integrating the latest updates on news, events, publications, clinical trials, funding opportunities, and many more. Methods: A team of expert biocurators is involved in the collection, validation and annotation of information with weekly updates on scientific literature collected from PubMed, while the curation strategy also involves the incorporation of new and updated information from existing public databases. ITHANET also accepts contributions to its content with acknowledgement of unpublished data in a specifically designed section. Results: The ITHANET Portal offers a wide range of curated databases, as follows: IthaGenes is a database that organises genes and variations affecting haemoglobinopathies and integrates the NCBI sequence viewer for detailed graphical representation of each variation. IthaMaps is a database that stores epidemiological information as documented in published literature and illustrates this information on a dynamic global to regional map for a total of over 196 countries. IthaChrom provides digitised reports of standard diagnostic high-performance liquid chromatography analyses as a reference tool for haemoglobinopathy diagnosis, allowing database searches of key data. IthaPhen is a database that demonstrates the correlations between genotype and phenotype and is a unique and powerful tool for clinicians and molecular geneticists Conclusions: The ITHANET Portal has a high-profile international governance structure and is already the most comprehensive knowledgebase on haemoglobinopathies. As an official partner of the Human Variome Project’s Global Globin Network, ITHANET has been selected for data storing, curation and sharing within and between countries, as well as for the development of a thalassaemia-specific genotype-phenotype database. In addition, ITHANET is coordinating an Hemoglobinopathy Variant Curation Expert Panel for haemoglobinopathy-specific variant classification under the Clinical Genome Resource. References 1. Kountouris P et al. ITHANET: Information and database community portal for haemoglobinopathies bioRxiv, 2017. 2. Kountouris P et al. IthaGenes: An interactive database for haemoglobin variations and epidemiology PLoS ONE, 9(7): e103020, 2014. 3. Robinson HM. Increasing the involvement of diverse populations in genomics-based health care-lessons from haemoglobinopathies. Journal of Community Genetics, 43, 295–298, 2017.
Employee Health and Wellness Outcomes Associated With Perceived Discrimination in Academic Medicine
Authors: Matthew D. Kearney, Frances K. Barg, Dominique Alexis, Eve Higginbotham, Jaya Aysola
Journal: JAMA Network Open (2022)

<h3>Importance</h3> Organizational culture and workplace interactions may enhance or adversely impact the wellness of all members of learning and work environments, yet a nuanced understanding of how such experiences within health care organizations impact the health and wellness of their membership is lacking. <h3>Objective</h3> To identify and characterize the reported health and wellness outcomes associated with perceived discrimination among academic medicine faculty, staff, and students. <h3>Design, Setting, and Participants</h3> This qualitative study analyzed anonymously submitted written narratives from 2016 that described experiences related to inclusion in the workplace or lack thereof. Narratives that described health outcomes associated with work- or school-based discrimination were purposively sampled. Participants were faculty, staff, and students at health-related schools or hospitals affiliated with the University of Pennsylvania. Data analysis was performed from March 2019 to January 2020. <h3>Exposures</h3> Self-reported experiences, both witnessed and personal, of discrimination in the workplace. <h3>Results</h3> A total of 315 narratives were collected, and 115 narratives from 115 participants were analyzed. Most respondents identified as female (70 respondents [60.9%]), non-Hispanic White (68 respondents [59.1%]), and heterosexual (89 respondents [77.4%]) and had worked at the institution for at least 1 year (99 respondents [86.0%]). The outcomes associated with adverse workplace experiences were broad and ranged in nature from emotional to mental and physical. Most reported outcomes were emotional (101 respondents [87.8%]), and more than 1 in 10 narratives (14 respondents [12.2%]) described a mental or physical health outcome. Many of the participants felt devaluated, overexerted, and hopeless, resulting in clinically relevant manifestations, such as increased stress and anxiety levels and even elevated blood pressure. <h3>Conclusions and Relevance</h3> This qualitative study identified a continuum of negative outcomes on employee health and well-being associated with perceived discrimination and chronic exclusion in the workplace. These findings suggest the need for organizations to promote inclusion as a component of workplace wellness interventions.
Ligelizumab for adolescent patients with CSU: first results from a dedicated Phase 2b study
Authors: Moshe Ben-Shoshan, Bulent Enis Sekerel, Petra Staubach-Renz, Montserrat Alvaro-Lozano, Marcus Maurer, Anton Drollmann, Andrzej Bienczak, Miriam Porter, Tian Liu, Alis Burciu, Thomas Severin
Journal: Journal of Allergy and Clinical Immunology (2022)
Nanocarrier mediated drug delivery as an impeccable therapeutic approach against Alzheimer’s disease
Authors: Rajeev Taliyan, Violina Kakoty, K.C. Sarathlal, Sanskruti Santosh Kharavtekar, Chandrashekar R. Karennanavar, Yogendra Kumar Choudhary, Gautam Singhvi, Yassine Riadi, Sunil Kumar Dubey, Prashant Kesharwani
Journal: Journal of Controlled Release (2022)
Checkpoint inhibition induced pruritus during cancer therapy is associated with skin IL-31 and CCL22 expression
Authors: Evelyn Wang, Taras Lyubchenko, Elena Goleva, Lukas Kraehenbuehl, Kwami Ketosugbo, Andrea Moy, Matthew Hellmann, Jeffery Kern, Mario Lacouture, Donald Leung
Journal: Journal of Allergy and Clinical Immunology (2022)
ANGINA PECTORIS AND ABDOMINIS.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Presence of Chronic rhinosinusitis (CRS) is Associated with Increased Healthcare Utilization in Patients with Asthma and Bronchiectasis (BE)
Authors: Margaret Kim, Thanh-Huyen Vu, Whitney Stevens, Michelle Prickett, David Conley, Atsushi Kato, Leslie Grammer, Robert Kern, Robert Schleimer, Brian Schwartz, Stephanie Smith, Lydia Suh, Bruce Tan, Kevin Welch, Anju Peters
Journal: Journal of Allergy and Clinical Immunology (2022)
Council on Medical Education and Hospitals
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOVINE AND HUMAN TUBERCULOSIS
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Software
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
How Ought Decisions That Weigh on Life and Death Be Justly Informed and Governed to Benefit More than the Privileged Few with Access to a Trusted Clinician?
Authors: Julia E. H. Brown, Barbara A. Koenig
Journal: The American Journal of Bioethics (2022)

This article refers to:From Reciprocity to Autonomy in Physician-Assisted Death: An Ethical Analysis of the Dutch Supreme Court Ruling in the Albert Heringa Case
Serratia marcescens
Authors: J. Terrance Davis
Journal: JAMA (1970)

During the 24-month period ending September 1969, a total of 662 isolates of Serratia marcescens were obtained from 314 patients. In 97% of the patients, isolates were from the urinary tract and this seemed to be the most common portal of entry. Blood was the second most common source of isolates, and 12 patients with septicemia had a mortality of 33% (4). In one instance Serratia septicemia was secondary to an infected prosthetic aortic valve.
Traumatic Spondylolysthesis
Authors: Otto E. Aufranc, William N. Jones, William H. Harris
Journal: JAMA (1964)

Dr. J. G. Manson: A 21-year-old man, involved in an automobile accident, was thrown from the car and landed on his back, possibly striking his back against a telephone pole. He was unconscious for a brief period immediately after the accident. At another hospital x-ray films of the lumbar spine showed a fracture of one and probably both superior articular facets of S1 with anterior dislocation of L5 on S1 (Fig 1). He had never had back symptoms prior to the accident. He was treated with bed rest, and the day after his injury he was unable to void urine or pass gas by rectum. A Foley catheter was placed in his bladder, and he was transferred to the Massachusetts General Hospital. At the time of admission his vital signs were stable. He was fully conscious and cooperative. Massive ecchymosis was present over the lumbar region and over the right
LETTER FROM LONDON
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical application of a novel integrated three-phase mapping technique for localization of the site of origin of idiophathic ventricular tachycardia
Authors: H.A.P. Peeters, A. SippensGroenewegen, E.F.D. Wever, H. Ramanna, A.C. Linnenbank, C.A. Grimbergen, N.M. van Hemel, R.N.W. Hauer, E.O. Robles de Medina
Journal: Journal of the American College of Cardiology (1998)
Convalescent plasma improves overall survival in patients with B-cell lymphoid malignancy and COVID-19: a longitudinal cohort and propensity score analysis
Authors: Thomas Hueso, Anne-Sophie Godron, Emilie Lanoy, Jérôme Pacanowski, Laura I. Levi, Emmanuelle Gras, Laure Surgers, Amina Guemriche, Jean-Luc Meynard, France Pirenne, Salim Idri, Pierre Tiberghien, Pascal Morel, Caroline Besson, Rémy Duléry, Sylvain Lamure, Olivier Hermine, Amandine Gagneux-Brunon, Nathalie Freymond, Sophie Grabar, Karine Lacombe
Journal: Leukemia (2022)
Heartsounds
Authors: Louis Borgenicht
Journal: JAMA (1980)

Medically related books, like medicine, are big business and have a uniquely successful track record in the world of publishing. The reasons for this are inherent in the subject matter: we are voyeurs peering into medicine's inner sanctum, witnessing the drama of life-and-death decisions, and experiencing the glories of medical life. Authors present us with outrageous facts of medical economics and politics and portray the concomitant simplicity and complexity of dying. The interested reader faces a barrage of new books dealing with any one of these topics. Against this plethoric background, the outstanding literary effort gains dramatic import.<i>Heartsounds</i>, by Martha Weinman Lear, is such a work. The book chronicles the lives of Harold and Martha Weinman Lear over the slightly more than four-year period before his death in September 1978. Lear had been a urologist in Hartford, Conn, who left practice two years before his first heart attack to