tbuckley/cabot-search huggingface dataset:
A case of mitral valve replacement with thrombo-embolism demonstrated at the Royal Postgraduate Medical School.
Journal: BMJ (1968)

The patient (Case No. 261083; P.M. No. 12272) was a woman aged 36 at the time of her death in 1967.At the age of 12 she had had rheumatic fever with known carditis.This led to a mild but persistent disability, which increased slowly.At the age of 25 she married but was advised not to have any children.One year later her exercise tolerance had further diminished; she was digitalized and there was some improve- ment.Her condition did not change for a number of years, and she was able to work as well as look after her house without very much difficulty (grade 2a).She was moderately short of breath and prone to bronchitis, but there was no oedema and no embolic complications.She was first seen at Hammersmith Hospital in 1961 at the age of 30.On examination she was a very small woman about 142 cm. in height and weighing only about 35 kg.The sternum bulged and there was a mild thoracic kyphosis, the shape of her thorax suggesting long-standing cardiomegaly.There was a marked malar flush.The arterial pulse was of small volume, and the rhythm was atrial fibrillation.The jugular venous pressure was normal and there were no congestive features.The cardiac impulse was diffuse.On auscultation a mitral pansystolic and mitral mid-diastolic murmur of three-quarter length were heard.An opening snap was audible 0.07 second after aortic valve closure (Fig. 1).No aortic or tricuspid valve murmurs could be heard and pulmonary valve closure was only slightly accentuated.The electrocardiogram showed atrial fibrillation and a mean frontal QRS axis of + 1000 suggesting right ventricular hypertrophy and therefore some pulmonary hypertension (Fig. 2).Radiography of the chest revealed an aneurysmal left atrium, pulmonary venous hypertension, and a calcified mitral valve (Fig. 3).A diagnosis of rheumatic heart disease with a rigid mitral valve, both stenotic and regurgitant, was made.There was no evidence of current rheumatic activity.In 1962 the patient was admitted for haemodynamic studies, which showed a normal cardiac output, moderate pulmonary arterial and left atrial hypertension, and a diastolic gradient across the mitral valve (see Table ).Retrograde left ventricular angiography showed an enlarged left ven- tricle, immobile mitral valve, and moderate mitral reflux.Aortography revealed no aortic regurgitation.It was concluded that the mitral valve was rigid, stenotic, and regurgitant and therefore unsuitable for anything other than replacement.As
Transactions of the Forty-eighth Annual Meeting of the Ohio State Medical Society held at Put-in-Bay
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medulloblastoma
Authors: Paul A. Northcott, Giles W. Robinson, Christian P. Kratz, Donald J. Mabbott, Scott L. Pomeroy, Steven C. Clifford, Stefan Rutkowski, David W. Ellison, David Malkin, Michael D. Taylor, Amar Gajjar, Stefan M. Pfister
Journal: Nature Reviews Disease Primers (2019)
Methyltransferase like 7B is a potential therapeutic target for reversing EGFR-TKIs resistance in lung adenocarcinoma
Authors: Huibin Song, Dongcheng Liu, Lingwei Wang, Kaisheng Liu, Chen Chen, Le Wang, Yi Ren, Bing Ju, Fuhua Zhong, Xingyu Jiang, Guangsuo Wang, Zhe-Sheng Chen, Chang Zou
Journal: Molecular Cancer (2022)

Identification of potential novel targets for reversing resistance to Epidermal Growth Factor Receptor (EGFR)-tyrosine kinase inhibitors (EGFR-TKIs) holds great promise for the treatment of relapsed lung adenocarcinoma (LUAD). In the present study, we aim to investigate the role of methyltransferase-like 7B (METTL7B) in inducing EGFR-TKIs resistance in LUAD and whether it could be a therapeutic target for reversing the resistance.METTL7B-overexpressed LUAD cell lines, gefitinib and osimertinib-resistant Cell-Derived tumor Xenograft (CDX) and Patient-Derived tumor Xenograft (PDX) mouse models were employed to evaluate the role of METTL7B in TKIs resistance. Ultraperformance liquid chromatography-tandem mass spectrometer (UPLC-MS/MS) was used to identify the metabolites regulated by METTL7B. Methylated RNA immunoprecipitation (MeRIP)-qPCR analysis was performed to measure the N6-methyladenosine (m6A) status of mRNA of METTL7B targeted genes. Gold nanocluster-assisted delivery of siRNA targeting METTL7B (GNC-siMETTL7B) was applied to evaluate the effect of METTL7B in TKIs resistance.Increased expression of METTL7B was found in TKIs-resistant LUAD cells and overexpression of METTL7B in LUAD cells induced TKIs resistance both in vitro and in vivo. Activated ROS-metabolism was identified in METTL7B-overexpressed LUAD cells, accompanied with upregulated protein level of GPX4, HMOX1 and SOD1 and their enzymatic activities. Globally elevated m6A levels were found in METTL7B-overexpressed LUAD cells, which was reduced by knock-down of METTL7B. METTL7B induced m6A modification of GPX4, HMOX1 and SOD1 mRNA. Knock-down of METTL7B by siRNA re-sensitized LUAD cells to gefitinib and osimertinib both in vitro and in vivo.This study uncovered a new critical link in METTL7B, glutathione metabolism and drug resistance. Our findings demonstrated that METTL7B inhibitors could be used for reversing TKIs resistance in LUAD patients.
A Query.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Section H. CARDIO-RESPIRATORY PHYSIOLOGY
Authors: S Lukasik, W Kornaszewski, N Lefcoe, R Carter, D Ahmad, M Collis, J Damoiseau, D De Pauw, J Vrijens, S Savi6, K Adamovid, B Dimitrijev1d
Journal: British Journal of Sports Medicine (1973)

with collapse without collapse 7 (64%) 15 (30%) 18 (14%) 13 (46%) 53 4 (36%) 36 (70%) 115 (86%) 15 (54%) 170 Number of cases 1 1 51 133 28 223 with no change of ST-T with slight flattening of T-waves with moderate flattening of T-waves with significant changes of ST-TIn isolated cases the electrocardiograms taken during high altitude hypoxia exhibited some abnormalities suggesting the existence of latent lesion of the myocardium.In this respect a few cases should be mentioned: one case with s-a block, one case with ventricular extrasystoles and 2 cases with pathologic elongation of QT interval. DiscussionAs can be seen in thle table I the most favourable I copyright.
Iodine Deficiency
Authors: Michael B. Zimmermann
Journal: Endocrine Reviews (2009)

Abstract Iodine deficiency has multiple adverse effects in humans, termed iodine deficiency disorders, due to inadequate thyroid hormone production. Globally, it is estimated that 2 billion individuals have an insufficient iodine intake, and South Asia and sub-Saharan Africa are particularly affected. However, about 50% of Europe remains mildly iodine deficient, and iodine intakes in other industrialized countries, including the United States and Australia, have fallen in recent years. Iodine deficiency during pregnancy and infancy may impair growth and neurodevelopment of the offspring and increase infant mortality. Deficiency during childhood reduces somatic growth and cognitive and motor function. Assessment methods include urinary iodine concentration, goiter, newborn TSH, and blood thyroglobulin. But assessment of iodine status in pregnancy is difficult, and it remains unclear whether iodine intakes are sufficient in this group, leading to calls for iodine supplementation during pregnancy in several industrialized countries. In most countries, the best strategy to control iodine deficiency in populations is carefully monitored universal salt iodization, one of the most cost-effective ways to contribute to economic and social development. Achieving optimal iodine intakes from iodized salt (in the range of 150–250 μg/d for adults) may minimize the amount of thyroid dysfunction in populations. Ensuring adequate iodine status during parenteral nutrition has become important, particularly in preterm infants, as the use of povidone-iodine disinfectants has declined. Introduction of iodized salt to regions of chronic iodine deficiency may transiently increase the incidence of thyroid disorders, but overall, the relatively small risks of iodine excess are far outweighed by the substantial risks of iodine deficiency.
Rotavirus infection
Authors: Sue E. Crawford, Sasirekha Ramani, Jacqueline E. Tate, Umesh D. Parashar, Lennart Svensson, Marie Hagbom, Manuel A. Franco, Harry B. Greenberg, Miguel O'Ryan, Gagandeep Kang, Ulrich Desselberger, Mary K. Estes
Journal: Nature Reviews Disease Primers (2017)
Ex vivo organotypic cultures for synergistic therapy prioritization identify patient-specific responses to combined MEK and Src inhibition in colorectal cancer
Authors: Nancy Gavert, Yaara Zwang, Roi Weiser, Orli Greenberg, Sharon Halperin, Oded Jacobi, Giuseppe Mallel, Oded Sandler, Adi Jacob Berger, Erez Stossel, Daniil Rotin, Albert Grinshpun, Iris Kamer, Jair Bar, Guy Pines, Daniel Saidian, Ilan Bar, Shay Golan, Eli Rosenbaum, Andrei Nadu, Eytan Ben-Ami, Rony Weitzen, Hovav Nechushtan, Talia Golan, Baruch Brenner, Aviram Nissan, Ofer Margalit, Dov Hershkovitz, Guy Lahat, Ravid Straussman
Journal: Nature Cancer (2022)
Cultural learning
Authors: Michael Tomasello, Ann Cale Kruger, Hilary Horn Ratner
Journal: Behavioral and Brain Sciences (1993)

Abstract This target article presents a theory of human cultural learning. Cultural learning is identified with those instances of social learning in which intersubjectivity or perspective-taking plays a vital role, both in the original learning process and in the resulting cognitive product. Cultural learning manifests itself in three forms during human ontogeny: imitative learning, instructed learning, and collaborative learning – in that order. Evidence is provided that this progression arises from the developmental ordering of the underlying social-cognitive concepts and processes involved. Imitative learning relies on a concept of intentional agent and involves simple perspective-taking. Instructed learning relies on a concept of mental agent and involves alternating/coordinated perspective-taking (intersubjectivity). Collaborative learning relies on a concept of reflective agent and involves integrated perspective-taking (reflective intersubjectivity). A comparison of normal children, autistic children and wild and enculturated chimpanzees provides further evidence for these correlations between social cognition and cultural learning. Cultural learning is a uniquely human form of social learning that allows for a fidelity of transmission of behaviors and information among conspecifics not possible in other forms of social learning, thereby providing the psychological basis for cultural evolution.
Treat yourself, right?
Authors: S. Freedman
Journal: JAMA (1984)

The lump above my clavicle burst upon my consciousness like popcorn over a gas flame, suddenly full size. Yet, at a centimeter, it clearly had taken more than a couple of days to arrive at its present dimension. An area of my body that previously received very little attention, being in need of neither daily dental flossing nor shaving, quickly became the focus of my conscious and unconscious stroking. Each day I would pause in conversation as I silently wondered how my lump was doing, or I would find the fingertips of my right hand floating gently over the area. Was it larger? Was it movable? Attached to the skin? The possibilities list was, of course, headed by the ominous. It became impossible to forget the discovery of a close friend's lymphoma during a yearly employee chest roentgenogram, while simultaneously forgetting how all medical students are successively afflicted by whatever
CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2013–2017
Authors: Quinn T Ostrom, Nirav Patil, Gino Cioffi, Kristin Waite, Carol Kruchko, Jill S Barnholtz-Sloan
Journal: Neuro-Oncology (2020)

The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration with the Centers for Disease Control (CDC) and National Cancer Institute (NCI), is the largest population-based registry focused exclusively on primary brain and other central nervous system (CNS) tumors in the United States (US) and represents the entire US population. This report contains the most up-to-date population-based data on primary brain tumors (malignant and non-malignant) and supersedes all previous CBTRUS reports in terms of completeness and accuracy. All rates (incidence and mortality) are age-adjusted using the 2000 US standard population and presented per 100,000 population. The average annual age-adjusted incidence rate (AAAIR) of all malignant and non-malignant brain and other CNS tumors was 23.79 (Malignant AAAIR=7.08, non-Malignant AAAIR=16.71). This rate was higher in females compared to males (26.31 versus 21.09), Blacks compared to Whites (23.88 versus 23.83), and non-Hispanics compared to Hispanics (24.23 versus 21.48). The most commonly occurring malignant brain and other CNS tumor was glioblastoma (14.5% of all tumors), and the most common non-malignant tumor was meningioma (38.3% of all tumors). Glioblastoma was more common in males, and meningioma was more common in females. In children and adolescents (age 0-19 years), the incidence rate of all primary brain and other CNS tumors was 6.14. An estimated 83,830 new cases of malignant and non-malignant brain and other CNS tumors are expected to be diagnosed in the US in 2020 (24,970 malignant and 58,860 non-malignant). There were 81,246 deaths attributed to malignant brain and other CNS tumors between 2013 and 2017. This represents an average annual mortality rate of 4.42. The 5-year relative survival rate following diagnosis of a malignant brain and other CNS tumor was 23.5% and for a non-malignant brain and other CNS tumor was 82.4%.
Government Services
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Multicentric, Randomized, Controlled Trial to Evaluate Blood Glucose Control by the Model Predictive Control Algorithm Versus Routine Glucose Management Protocols in Intensive Care Unit Patients
Authors: Johannes Plank, Jan Blaha, Jeremy Cordingley, Malgorzata E. Wilinska, Ludovic J. Chassin, Cliff Morgan, Stephen Squire, Martin Haluzik, Jaromir Kremen, Stepan Svacina, Wolfgang Toller, Andreas Plasnik, Martin Ellmerer, Roman Hovorka, Thomas R. Pieber
Journal: Diabetes Care (2006)
Targeting macrophages for enhancing CD47 blockade–elicited lymphoma clearance and overcoming tumor-induced immunosuppression
Authors: Xu Cao, Yingyu Wang, Wencan Zhang, Xiancai Zhong, E. Gulsen Gunes, Jessica Dang, Jinhui Wang, Alan L. Epstein, Christiane Querfeld, Zuoming Sun, Steven T. Rosen, Mingye Feng
Journal: Blood (2022)
Age‐specific effectiveness of primary human papillomavirus screening versus cytology in a cervical cancer screening program: a nationwide cross‐sectional study
Authors: Heling Bao, Lan Ma, Yanxia Zhao, Bo Song, Jiangli Di, Linhong Wang, Yanqiu Gao, Wenhui Ren, Shi Wang, Jiuling Wu, Hai‐Jun Wang
Journal: Cancer Communications (2022)

Abstract Background Primary human papillomavirus (HPV) screening is recommended for the detection of cervical intraepithelial neoplasia (CIN) in the general population; however, the triage for HPV‐positive women remains a challenge. This study aimed to evaluate the age‐specific effectiveness of primary HPV screening versus primary cytology screening for identifying optimal strategies for women of different ages. Methods The dataset of the prevalence round screening was derived from the National Cervical Cancer Screening Program in China. Primary cervical screening protocols included cytology only, HPV testing with cytology triage, and HPV testing with HPV‐16/18 genotyping plus cytology triage. The primary outcomes were age‐specific detection rate, colposcopy referral rate and positive predictive value (PPV) for CIN2+. Multivariate Poisson regression was used to evaluate the relative effectiveness of HPV testing and cytology according to age groups. The I 2 statistic with a random‐effect model was used to test the heterogeneity in relative effectiveness of HPV testing versus cytology between age groups. Results This study included 1,160,981 women. HPV testing with HPV‐16/18 genotyping plus cytology triage significantly increased the CIN2+ detection by 36% (rate ratio [RR]: 1.36, 95% confidential interval [CI] 1.21–1.54) for women aged 35‐44 years and by 34% (RR: 1.34, 95% CI 1.20‐1.51) for women aged 45‐54 years compared with cytology only. HPV testing with cytology triage had similar CIN2+ detection rate compared with cytology only. The PPVs were substantially increased for both HPV testing groups. Among women aged 55‐64 years old, HPV testing with HPV‐16/18 genotyping plus cytology triage increased the colposcopy referral rate by 19% (RR 1.19, 95% CI 1.10‐1.29) compared with cytology only, but did not increase the CIN2+ detection (1.09, 0.91–1.30). The effectiveness of HPV testing with cytology triage did not change in older women. The between‐age‐group heterogeneity in the effectiveness was statistically significant for HPV testing with HPV‐16/18 genotyping plus cytology triage versus cytology only. Conclusions Our results suggested that the effectiveness of primary HPV screening with different triage strategies differed among age groups. HPV testing with HPV‐16/18 genotyping plus cytology triage could be used for women aged 35‐54 years to detect more lesions, and HPV testing with cytology triage could balance the CIN2+ detection and the number of colposcopies for women aged 55‐64 years. Longitudinal data including both prevalence and incidence screening rounds are warranted to assess age‐specific triage strategies.
Correction
Journal: British Journal of Sports Medicine (2007)

Background: It is well documented that heat acclimation of 6 or more sessions of at least 60 min duration prolongs the time to exhaustion during endurance walking, cycling and running in the heat.However, this type of acclimation is not specific to team sport activity and the effect of acclimation on prolonged high intensity intermittent running has not yet been investigated.Objective: To assess the impact of an intermittent acclimation protocol on distance run during team sport activity.Methods: The impact of 4 short heat acclimation sessions (30 -45 min of the Loughborough Intermittent Shuttle Test; LIST) on high-intensity intermittent running capacity (LIST) in the heat (30 o C, 27% RH), was examined.Seventeen female welltrained games players were split into 3 groups; an acclimation group (30 o C, 24% RH), a moderate training group (18 o C, 41% RH), and a control group who did not complete any training between the main trials (pre-and post-acclimation).The pre-(A) and post-acclimation (B) trials were separated by 28 days to control for menstrual phase and verified using hormonal analysis.The 4 acclimation or moderate training sessions utilising the LIST were completed with one or two rest days interspersed between each session in a 10-day period prior to the post-acclimation trial (B).Results: In the post-acclimation trial distance run was increased by 33% in the acclimation group (A: 7703 ± 1401 vs B: 10215 ± 1746m; interaction group x trial P<0.05), but was unchanged in the moderate and control groups.The acclimation group had a lower rectal temperature (interaction group x trial x time P<0.01) due to a lower rate of rise, and an increase in thermal comfort [1] after acclimation (End A: 7 ± 2 vs 6 ± 2; interaction group x trial P<0.01).There was no difference in serum