tbuckley/cabot-search huggingface dataset:
Reply to B. Li et al
Authors: Ben M. Eyck, Bas P. L. Wijnhoven, J. Jan B. van Lanschot
Journal: Journal of Clinical Oncology (2021)

We thank our colleagues Li and Chen 1 for their comments in response to our article. 2Indeed, there is still no full consensus about the best treatment strategy for locally advanced esophageal cancer and more specifically about the optimal neoadjuvant regimen.Li and Chen 1 argue that extended lymphadenectomy is a crucial part of treatment in these patients and that the neoadjuvant chemoradiotherapy as applied in the CROSS trial simply compensated for inadequate surgery.We feel that their viewpoint is not supported by the available evidence.
Ipilimumab versus ipilimumab plus anti-PD-1 for metastatic melanoma – Authors' reply
Authors: Ines Pires da Silva, Tasnia Ahmed, Irene L M Reijers, Allison Betof Warner, James Randall Patrinely, Patricio Serra-Bellver, Clara Allayous, Joanna Mangana, Lisa Zimmer, Claudia Trojaniello, Oliver Klein, Camille L Gerard, Olivier Michielin, Andrew Haydon, Paolo A Ascierto, Matteo S Carlino, Celeste Lebbe, Paul Lorigan, Douglas B Johnson, Shahneen Sandhu, Serigne N Lo, Alexander M Menzies, Georgina V Long
Journal: The Lancet Oncology (2021)
Elexacaftor/Tezacaftor/Ivacaftor Improved Clinical Outcomes in a Patient with N1303K-CFTR Based on <i>In Vitro</i> Experimental Evidence
Authors: Yunjie Huang, Grace Paul, Jesun Lee, Sunitha Yarlagadda, Karen McCoy, Anjaparavanda P. Naren
Journal: American Journal of Respiratory and Critical Care Medicine (2021)

"Elexacaftor/Tezacaftor/Ivacaftor Improved Clinical Outcomes in a Patient with N1303K-CFTR Based on In Vitro Experimental Evidence." American Journal of Respiratory and Critical Care Medicine, 204(10), pp. 1231–1235
Therapeutics: Its Principles and Practice.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase Ib study of patients with metastatic castrate-resistant prostate cancer treated with different sequencing regimens of atezolizumab and sipuleucel-T
Authors: Tanya Dorff, Yosuke Hirasawa, Jared Acoba, Ian Pagano, David Tamura, Sumanta Pal, Minlu Zhang, Rebecca Waitz, Abhilash Dhal, Winston Haynes, John Shon, Mark Scholz, Hideki Furuya, Owen T M Chan, Jeffrey Huang, Charles Rosser
Journal: Journal for ImmunoTherapy of Cancer (2021)

Combining an immune checkpoint inhibitor with a tumor vaccine may modulate the immune system to leverage complementary mechanisms of action that lead to sustained T-cell activation and a potent prolonged immunotherapeutic response in metastatic castration resistant prostate cancer (mCRPC).Subjects with asymptomatic or minimally symptomatic mCRPC were randomly assigned in a 1:1 ratio to receive either atezolizumab followed by sipuleucel-T (Arm 1) or sipuleucel-T followed by atezolizumab (Arm 2). The primary endpoint was safety, while secondary endpoints included preliminary clinical activity such as objective tumor response and systemic immune responses that could identify key molecular and immunological changes associated with sequential administration of atezolizumab and sipuleucel-T.A total of 37 subjects were enrolled. The median age was 75.0 years, median prostate specific antigen (PSA) was 21.9 ng/mL, and subjects had a median number of three prior treatments. Most subjects (83.8%) had at least one treatment-related adverse event. There were no grade 4 or 5 toxicities attributed to either study drug. Immune-related adverse events and infusion reactions occurred in 13.5% of subjects, and all of which were grade 1 or 2. Of 23 subjects with Response Evaluation Criteria in Solid Tumors measurable disease, only one subject in Arm 2 had a partial response (PR) and four subjects overall had stable disease (SD) at 6 months reflecting an objective response rate of 4.3% and a disease control rate of 21.7%. T-cell receptor diversity was higher in subjects with a response, including SD. Immune response to three novel putative antigens (SIK3, KDM1A/LSD1, and PIK3R6) appeared to increase with treatment.Overall, regardless of the order in which they were administered, the combination of atezolizumab with sipuleucel-T appears to be safe and well tolerated with a comparable safety profile to each agent administered as monotherapy. Correlative immune studies may suggest the combination to be beneficial; however, further studies are needed.NCT03024216.
RETRACTED ARTICLE: Statins significantly repress rotavirus replication through downregulation of cholesterol synthesis
Authors: Shihao Ding, Bingting Yu, Anneke J. van Vuuren
Journal: Gut Microbes (2021)

Rotavirus is the most common cause of severe diarrhea among infants and young children and is responsible for more than 200,000 pediatric deaths per year. There is currently no pharmacological treatment for rotavirus infection in clinical activity. Although cholesterol synthesis has been proven to play a key role in the infections of multiple viruses, little is known about the relationship between cholesterol biosynthesis and rotavirus replication. The models of rotavirus infected two cell lines and a human small intestinal organoid were used. We investigated the effects of cholesterol biosynthesis, including inhibition, enhancement, and their combinations on rotavirus replication on these models. The knockdown of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) was built by small hairpin RNAs in Caco2 cells. In all these models, inhibition of cholesterol synthesis by statins or HMGCR knockdown had a significant inhibitory effect on rotavirus replication. The result was further confirmed by the other inhibitors: 6-fluoromevalonate, Zaragozic acid A and U18666A, in the cholesterol biosynthesis pathway. Conversely, enhancement of cholesterol production increased rotavirus replication, suggesting that cholesterol homeostasis is relevant for rotavirus replication. The effects of all these compounds toward rotavirus were further confirmed with a clinical rotavirus isolate. We concluded that rotavirus replication is dependent on cholesterol biosynthesis. To be specific, inhibition of cholesterol synthesis can downregulate rotavirus replication; on the contrary, rotavirus replication is upregulated. Statin treatment is potentially an effective novel clinical anti-rotavirus strategy.
Prodromal Symptoms in Depression: A Systematic Review
Authors: Giada Benasi, Giovanni A. Fava, Jenny Guidi
Journal: Psychotherapy and Psychosomatics (2021)

Introduction: Appraisal of prodromal symptoms of unipolar depression may complement the traditional cross-sectional approach and provide a longitudinal perspective, according to a staging model of the illness. Objective: To provide an updated systematic review of clinical studies concerned with prodromal symptoms of unipolar depression, according to PRISMA guidelines. Methods: Keyword searches were conducted in PubMed, Scopus, and Web of Science. Longitudinal studies on prodromal symptoms and signs in adult patients primarily diagnosed with unipolar depression were selected. Findings were examined separately according to study design (i.e., retrospective or prospective). Results: Twenty-five studies met the criteria for inclusion in this systematic review. Findings indicate that a distinct prodromal symptomatology – commonly characterized by anxiety, tension, irritability, and somatic complaints – exists before the onset of unipolar depression. The duration of the prodromal phase was highly variable across studies, ranging from less than a month to several years. Prodromal symptoms profile and duration were consistent within individuals across depressive episodes. There was a close relationship between prodromal and residual symptoms of the same depressive episode. Conclusions: The present systematic review addresses an important, and yet relatively neglected, clinical issue that deserves further investigation and may be of immediate practical value. The findings provide challenging insights into the pathogenesis and course of unipolar depression, which may result in more timely and effective treatment of recurrences. The definition of a prodromal phase in depression would benefit from the joint use of symptom identification, biomarkers, and neuroimaging.
The role of cigarette smoking-derived pollutants in the risk of mortality in idiopathic pulmonary fibrosis
Authors: Taro Yasuma, Corina N. D'Alessandro-Gabazza, Osamu Hataji, Tetsu Kobayashi, Esteban C. Gabazza
Journal: European Respiratory Journal (2021)

We read with great interest the work reported by Yoon et al . [1]. The authors found that a high concentration of nitrogen dioxide at an individual's residential address is significantly associated with increased mortality in idiopathic pulmonary fibrosis (IPF) patients when all confounders are included in the health analysis model. However, an important question that remains unclear in the study is whether active or passive cigarette smoking-associated release of nitrogen dioxide or particulate matter plays a role in the clinical outcome of IPF patients. The role of pollutants derived from cigarette smoke in the mortality of patients with pulmonary fibrosis <https://bit.ly/3pbuPDc>
miR-766-5p Targets Super-Enhancers by Downregulating CBP and BRD4
Authors: Yasuyuki Gen, Tomoki Muramatsu, Jun Inoue, Johji Inazawa
Journal: Cancer Research (2021)

Super-enhancers (SE) are clusters of transcription enhancers that drive gene expression. SEs are typically characterized by high levels of acetylation of histone H3 lysine 27 (H3K27ac), which is catalyzed by the histone lysine acetyltransferase CREB binding protein (CBP). Cancer cells frequently acquire tumor-specific SEs at key oncogenes, such as MYC, which induce several hallmarks of cancer. BRD4 is recruited to SEs and consequently functions as an epigenetic reader to promote transcription of SE-marked genes in cancer cells. miRNAs can be potent candidates for nucleic acid therapeutics for cancer. We previously identified miR-766-5p as a miRNA that downregulated MYC expression and inhibited cancer cell growth in vitro. In this study, we show that miR-766-5p directly targets CBP and BRD4. Concurrent suppression of CBP and BRD4 cooperatively downregulated MYC expression in cancer cells but not in normal cells. Chromatin immunoprecipitation analysis revealed that miR-766-5p reduced levels of H3K27ac at MYC SEs via CBP suppression. Moreover, miR-766-5p suppressed expression of a BRD4-NUT fusion protein that drives NUT midline carcinoma. In vivo administration of miR-766-5p suppressed tumor growth in two xenograft models. Collectively, these data suggest that targeting SEs using miR-766-5p-based therapeutics may serve as an effective strategy for the treatment of MYC-driven cancers. SIGNIFICANCE: This study demonstrates that miR-766-5p targets CBP and BRD4, which can mitigate the protumorigenic consequences of SEs and oncogenic fusion proteins.
Delays in Care Associated With Non–English-Speaking Patients With Breast Cancer
Authors: Katy E. Balazy, Cecil M. Benitez, Paulina M. Gutkin, Clare E. Jacobson, Rie von Eyben, Kathleen C. Horst
Journal: Journal of the National Comprehensive Cancer Network (2021)

Background: Breast cancer care requires coordination between multiple diagnostic and treatment modalities. Disparities such as age, race/ethnicity, and socioeconomic status are associated with delays in care. This study investigates whether primary language is associated with delays in breast cancer diagnosis and treatment before and through radiotherapy (RT). Patients and Methods: This study was an institutional retrospective matched-cohort analysis of women treated with breast RT over 2 years. A total of 65 non–English-speaking (NES) patients were matched with 195 English-speaking (ES) patients according to stage, age, and chemotherapy delivery. Key time intervals along the breast cancer care path from initial findings through RT were recorded. Data were analyzed in a mixed model with matching as the random effect. The impact of race and insurance status was analyzed in addition to language. Results: Significant delays were found for NES patients, which varied by race. NES Latina patients experienced the longest delay, with a mean total care-path time of 13.53 months (from initial findings to end of RT) versus 8.18 months for all ES patients ( P &lt;.0001). Specifically, their mean total care-path time was 5.97 months longer than that of ES Latina patients ( P =.001) and 5.80 months longer than that of ES White patients ( P &lt;.0001). In addition, NES Latina patients had a significantly longer total care-path time than NES patients of other races/ethnicities ( P =.001). Delays were specifically seen between initial clinical or radiographic findings and diagnostic mammogram ( P =.001) and between biopsy and resection ( P =.044). Beyond language, race/ethnicity was itself associated with delays between resection and start of RT ( P =.032) and between start and end of RT ( P =.022). Conclusions: Language is associated with pre-RT delays in breast cancer care, especially for NES Latina patients. Delays are most pronounced before diagnostic mammograms, but they also exist before resection and RT. Future work should target NES patients to assist their progress along the care path.
Abstract 185: Emergency Calls Made Away from the Out-of-Hospital Cardiac Arrest Scene Are Frequently Classified as an Uninformative “Hearsay Call” and Associated with Poor Outcomes
Authors: Yoshio Tanaka, Daiki Nishi, Yutaka Takei, Miki Enami, Keisuke Ohta, Hideo Inaba
Journal: Circulation (2011)

Backgrounds and Aim Emergency calls made away from the scene may affect the incidences of telephone-cardiopulmonary resuscitation (CPR) and bystander CPR, and hence may modify the prognosis of out-of -hospital cardiac arrests (OHCAs) recognized or witnessed by citizens. The aims of this study are to investigate the incidence and causes of emergency calls away from the scene and to study their effects on the prognosis of OHCAs. Methods Data from 4861 OHCAs that occurred from April, 2004 to March, 2010 in Ishikawa prefecture were prospectively collected and analyzed. The emergency calls made away from the scene were identified by dispatch records and interviews to callers and/or bystanders. Results The incidence of emergency calls made away from the scene was 15.2% (737/4861) for all OHCAs and 10.2% (328/3228) for OHCAs that occurred at home. More than half of emergency call away from the scene was preventable and classified as an uninformative “hearsay” call (52% for all OHCAs and 58% for OHCAs at home). The emergency calls away from the scene were associated with low incidences of telephone-CPR and bystander CPR, and 1-M and 1-Y survivals. Mutiple logistic regression analysis revealed that emergency call made awayfrom the scene is one of independent factors associated with poor outcomes. Conclusions Emergency calls made away from the OHCAs scene are frequently classified as an uninformative “hearsay call” and associated with poor outcomes due to low incidences of telephone-CPR and bystander CPR. We should make it known to laypersons in society that they should make an emergency call by themselves as close as to the scene where someone becomes unresponsive.
CHART-2(東北地域における慢性心不全の解析と登録-2)研究-日本における観察研究の作業モデル-
Authors: Sakata Yasuhiko, Miura Masanobu, Tadaki Soichiro, Ushigome Ryoichi, Sato Kenjiro, Yamauchi Takeshi, Tsuji Kanako, Onose Takeo, Abe Ruri, Oikawa Takuya, Kasahara Shintaro, Nochioka Kotaro, Takahashi Jun, Miyata Satoshi, Shimokawa Hiroaki
Journal: Circulation (2016)
Plasma-activated thermosensitive biogel as an exogenous ROS carrier for post-surgical treatment of cancer
Authors: Hao Zhang, Shengduo Xu, Jishen Zhang, Zifeng Wang, Dingxin Liu, Li Guo, Cheng Cheng, Yilong Cheng, Dehui Xu, Michael G. Kong, Mingzhe Rong, Paul K. Chu
Journal: Biomaterials (2021)
Evidence for a Colorectal Cancer Screening Benefit After Age 75 Years
Authors: Anita Slomski
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FDA Approves Skin Graft Alternative for Thermal Burns
Authors: Bridget M. Kuehn
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Solid self emulsifying drug delivery system: Superior mode for oral delivery of hydrophobic cargos
Authors: Indrani Maji, Srushti Mahajan, Anitha Sriram, Pravin Medtiya, Ravindra Vasave, Dharmendra Kumar Khatri, Rahul Kumar, Shashi Bala Singh, Jitender Madan, Pankaj Kumar Singh
Journal: Journal of Controlled Release (2021)
Control of the activity of CAR-T cells within tumours via focused ultrasound
Authors: Yiqian Wu, Yahan Liu, Ziliang Huang, Xin Wang, Zhen Jin, Jiayi Li, Praopim Limsakul, Linshan Zhu, Molly Allen, Yijia Pan, Robert Bussell, Aaron Jacobson, Thomas Liu, Shu Chien, Yingxiao Wang
Journal: Nature Biomedical Engineering (2021)
P-89 The correlation between adverse events and survival benefits of donafenib in the first-line treatment of advanced hepatocellular carcinoma
Authors: F. Bi, S. Qin, J. Xu, C. Du, Q. Fan, L. Zhang, M. Tao, D. Jiang, S. Wang, Y. Chen, J. Sheng, X. Zhuang, J. Wu, L. Liu
Journal: Annals of Oncology (2021)
P-153 Safety and effectiveness of sorafenib in elderly patients diagnosed with advanced hepatocellular carcinoma in a monographic oncologic center
Authors: Z. Vidales Sepulveda, N. Gómez Serra, B. Laquente Saez, V. Navarro Pérez, C. Sánchez, None î Serra Solé, S. Ruiz Osuna, M. Rota Roca, E. Ramos Rubio, J. Joudanin Seijo, M. Galán Guzmán, D. Leiva, A. Amador Navarrete, L. Lladó, T. Serrano, M. García Guix, L. Martínez Carnicero, K. Mils Julià, C. Iglesias Míguez, L. del Carpio, X. Xiol Quingles, M. Calvo Campos
Journal: Annals of Oncology (2021)
Modified Ultrafiltration Reduces Morbidity After Adult Cardiac Operations
Authors: Giovanni Battista Luciani, Tiziano Menon, Barbara Vecchi, Stefano Auriemma, Alessandro Mazzucco
Journal: Circulation (2001)

Background Extracorporeal circulation contributes to morbidity after open-heart surgery by causing a systemic inflammatory reaction. Modified ultrafiltration is a technique able to remove the fluid overload and inflammatory mediators associated with use of cardiopulmonary bypass. It has been shown to reduce morbidity after cardiac operations in children, but the impact on adult cardiac procedures is unknown. Methods and Results Five hundred seventy-three consecutive adult patients were prospectively randomized to either ultrafiltration after cardiopulmonary bypass (treatment) or to no ultrafiltration (control). Parsonnet score was used to assess the severity of the patients’ clinical conditions. Analysis was done with Student’s t test or Mann-Whitney U test for continuous variables and Fisher’s exact test or Pearson’s χ 2 for discrete variables. Hospital mortality was 2.5% (7 of 284) in the treatment group versus 3.8% (11 of 289) in the control group ( P =0.357). Hospital morbidity was lower in treated patients (66 of 284 [23.2%] versus 117 of 289 [40.5%], P =0.0001). Cardiac morbidity was similar (26 of 284 [9.1%] versus 35 of 289 [12.1%], P =0.251), whereas significantly lower rates of respiratory (20 of 284 [7.0%] versus 36 of 289 [12.5%], P =0.029), neurological (5 of 284 [1.8%] versus 14 of 289 [4.8%], P =0.039), and gastrointestinal (0 of 284 versus 4 of 289 [1.4%], P =0.044) complications were found in treated patients. Transfusion requirements were also lower in treated patients (1.66±2.6 versus 2.25±3.8 U/patient, P =0.039). Duration of intensive care (39.9±49.2 versus 46.3±72.8 hours, P =0.218) and hospital stay (7.6±3.5 versus 7.9±4.4 days, P =0.372) were comparable. Conclusions Modified ultrafiltration after cardiopulmonary bypass is associated with a lower prevalence of early morbidity and lower blood transfusion requirements. The impact on length of hospital stay needs further analysis. Routine application of modified ultrafiltration after adult cardiac operations is warranted.
Abstract 14844: Beta Blockers After HFrEF Hospitalization Decrease Short Term Mortality Across the Age Spectrum
Authors: Lauren G Gilstrap, Andrea M Austin, Barbara Gladders, James O’Malley, Amber Barnato, Anna Tosteson, Jonathan Skinner
Journal: Circulation (2019)

Introduction: Beta-blockers are a standard therapy for heart failure with reduced ejection fraction (HFrEF) and their use after hospitalization for HFrEF is a commonly used HF quality metric. Howev...
トキシック・ショック症候群にみられた分離黄色ブドウ球菌産生の新しいブドウ球菌性エンテロトキシン,エンテロトキシンF
Authors: Bergdoll M S, Crass B A, Reiser R F, Robbins R N, Davis J P
Journal: The Lancet (1981)