tbuckley/cabot-search huggingface dataset:
Critical Role of Notch‐1 in Mechanistic Target of Rapamycin Hyperactivity and Vascular Inflammation in Patients With Takayasu Arteritis
Authors: Wanwan Jiang, Mengyao Sun, Ying Wang, Ming Zheng, Zixin Yuan, Shixiong Mai, Xin Zhang, Longhai Tang, Xiyu Liu, Chunhong Wang, Zhenke Wen
Journal: Arthritis & Rheumatology (2022)

Takayasu arteritis (TA) is a major type of large vessel vasculitis characterized by progressive inflammation in vascular layers. In our recent study we identified a central role of mechanistic target of rapamycin (mTOR) hyperactivity in proinflammatory T cell differentiation in TA. This study was undertaken to explore potential mechanisms underpinning T cell-intrinsic mTOR hyperactivity and vascular inflammation in TA, with a focus on Notch-1.Notch-1 expression and activity was determined according to Notch-1, activated Notch-1, and HES-1 levels. We detected mTOR activity with intracellular expression of phosphorylated ribosomal protein S6. Differentiation of proinflammatory T cells was analyzed by detecting Th1 and Th17 lineage-determining transcription factors. The function of Notch-1 was evaluated using γ-secretase inhibitor DAPT and gene knockdown using a short hairpin RNA (shRNA) strategy. We performed our translational study using humanized NSG mouse chimeras in which human vasculitis was induced using immune cells from TA patients.CD4+ T cells from TA patients exerted Notch-1high , leading to mTOR hyperactivity and spontaneous maldifferentiation of Th1 cells and Th17 cells. Blockade of Notch-1 using DAPT and Notch-1 shRNA efficiently abrogated mTOR complex 1 (mTORC1) activation and proinflammatory T cell differentiation. Mechanistically, Notch-1 promoted mTOR expression, interacted with mTOR, and was associated with lysosomal localization of mTOR. Accordingly, systemic administration of DAPT and CD4+ T cell-specific gene knockdown of Notch-1 could alleviate vascular inflammation in humanized TA chimeras.Expression of Notch-1 is elevated in CD4+ T cells from TA patients, resulting in mTORC1 hyperactivity and proinflammatory T cell differentiation. Targeting Notch-1 is a promising therapeutic strategy for the clinical management of TA.
Grading President Clinton's health proposal
Authors: U. E. Reinhardt
Journal: JAMA (1993)

MAY IS that otherwise lovely month when American college professors are buried under mountains of examinations, papers, and dissertations, each waiting to be read and graded. This year, for some of us, the month of May will bring an extra assignment: Bill and Hillary Clinton's weighty tome on health care reform, coauthored by them, with the assistance of Ira Magaziner and some 500 additional miniauthors known in the trade as The Task Force. The tome is likely to span dozens of chapters and hundreds of pages, but these can be organized into three parts, reflecting the conventional three goals of health care reform:<i>better cost control, better quality control</i>, and<i>universal health insurance coverage</i>. To assign the proposal an overall grade one should, first, grade each part separately and then collapse the three scores into an overall weighted average grade, where the weight assigned to each part represents the relative
Usefulness of a screw tip stent retriever as a dilator during side-by-side placement of multiple stents for malignant hilar biliary obstruction
Authors: Haruka Toyonaga, Tsuyoshi Hayashi, Akio Katanuma
Journal: Endoscopy (2022)

In malignant hilar biliary obstruction, an additional stent placement is often difficult after the placement of fully covered self-expandable metal stents (FCSEMSs) in a side-by-side fashion.
Extracorporeal Circulation and Digoxin Level in the Heart
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Commentary on: Is the renal subcapsular space the preferred site for clinical porcine islet xenotransplantation? Review article (Int J Surg 2019 Jul 30;69:100-107. https://doi.org/10.1016/j.ijsu.2019.07.032. [Epub ahead of print])
Authors: Henk-Jan Schuurman, Melanie L Graham
Journal: International Journal of Surgery (2019)
Books in Brief
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Meta-analysis defines predominant shared microbial responses in various diseases and a specific inflammatory bowel disease signal
Authors: Haya Abbas-Egbariya, Yael Haberman, Tzipi Braun, Rotem Hadar, Lee Denson, Ohad Gal-Mor, Amnon Amir
Journal: Genome biology (2022)

Gut microbial alteration is implicated in inflammatory bowel disease but is noted in other diseases. Systematic comparison to define similarities and specificities is hampered since most studies focus on a single disease.
A Correction
Journal: BMJ (1908)

BumNinvaluable to students of the subject, the abstracts of.the various-papers being short and to the point.-In future.numbers the current literature of trypanosomiasis will be dealt with, one or more aspects of the subjects being treated in detail.The card index, bibliography, and library of the Bureau may be consulted every morning between 10.30 and 1.30, and already the library contains a
Commentaire de travail de M. Ikeda et al., pp. 837
Journal: Endoscopy (2010)

See also: Usefulness of endoscopic retrograde biliary biopsy using large-capacity forceps for extrahepatic biliary strictures: a prospective randomized studyEndoscopy 2010; 42(10): 837-841DOI: 10.1055/s-0030-1255633
Invincible arrogance--and patients suffer.
Journal: BMJ (1981)

sprinters lack stamina, but I imagine that no one would question their cardiopulmonary fitness-while in training.I am also worried by the modified physical fitness index, as this fails to take account of the resting pulse rate.Surely a formula based on percentage increase over resting rate at two, five, and 10 minutes would seem more reasonable, since the normal resting pulse rate can vary from the 40s to the 90s at least-or does a naturally slow pulse rate confer a fitness advantage ?Interestingly, Lieutenant-ColonelPearn referred to Zatopek's fitness index of 172; he was a distance runner with a resting pulse rate of about 40 per minute.But I wonder how Zatopek would have fared on the squash court, where explosive bursts of energy are required, or in gymnastics, in which a completely different sort of fitness and body control is demanded, or in the swimming pool.He certainly would have been
Miscellanea Medica
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The World Health Network: a global citizens' initiative
Authors: Yaneer Bar-Yam, Deepti Gurdasani, Michael G Baker, Gabriel Scally, Simone George, Amanda Kvalsvig, Sinéad Ní Fhaoláin, Shu-Ti Chiou, John Drury, Stephen Duckett, Eric L Ding, Carlos Gershenson, Christine Gibson, Trisha Greenhalgh, Adam Hamdy, Zoë Hyde, Tiffany James, Jose L Jimenez, Martin McKee, Susan Michie, Christina Pagel, Cecile Philippe, Kim Prather, Sunil K Raina, Walter Ricciardi, Meir Rubin, Tomás Ryan, Matthias F Schneider, Anthony Staines, Robert West, Hisham Ziauddeen
Journal: The Lancet (2021)
BELGIUM
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Practical Medicine Series of Year Books, Comprising Ten Volumes of the Year's Progress in Medicine and Surgery, Issued Monthly. Under the General Editorial Charge of Gustavus P. Head. M.D., Professor of Laryngology and Rhinology, Chicago Post-Graduate Medical School. Volume IX. Physiology. Pathology. Bacteriology, Anatomy.
Journal: JAMA (1902)

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Population-Genomic Analysis Identifies a Low Rate of Global Adaptive Fixation in the Proteins of the Cyclical Parthenogen<i>Daphnia magna</i>
Authors: Peter D Fields, Seanna McTaggart, Céline M O Reisser, Christoph Haag, William H Palmer, Tom J Little, Dieter Ebert, Darren J Obbard
Journal: Molecular Biology and Evolution (2022)

Daphnia are well-established ecological and evolutionary models, and the interaction between D. magna and its microparasites is widely considered a paragon of the host-parasite coevolutionary process. Like other well-studied arthropods such as Drosophila melanogaster and Anopheles gambiae, D. magna is a small, widespread, and abundant species that is therefore expected to display a large long-term population size and high rates of adaptive protein evolution. However, unlike these other species, D. magna is cyclically asexual and lives in a highly structured environment (ponds and lakes) with moderate levels of dispersal, both of which are predicted to impact upon long-term effective population size and adaptive protein evolution. To investigate patterns of adaptive protein fixation, we produced the complete coding genomes of 36 D. magna clones sampled from across the European range (Western Palaearctic), along with draft sequences for the close relatives D. similis and D. lumholtzi, used as outgroups. We analyzed genome-wide patterns of adaptive fixation, with a particular focus on genes that have an a priori expectation of high rates, such as those likely to mediate immune responses, RNA interference against viruses and transposable elements, and those with a strongly male-biased expression pattern. We find that, as expected, D. magna displays high levels of diversity and that this is highly structured among populations. However, compared with Drosophila, we find that D. magna proteins appear to have a high proportion of weakly deleterious variants and do not show evidence of pervasive adaptive fixation across its entire range. This is true of the genome as a whole, and also of putative 'arms race' genes that often show elevated levels of adaptive substitution in other species. In addition to the likely impact of extensive, and previously documented, local adaptation, we speculate that these findings may reflect reduced efficacy of selection associated with cyclical asexual reproduction.
The Public Service.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The future of cystic fibrosis care: a global perspective
Authors: Scott C Bell, Marcus A Mall, Hector Gutierrez, Milan Macek, Susan Madge, Jane C Davies, Pierre-Régis Burgel, Elizabeth Tullis, Claudio Castaños, Carlo Castellani, Catherine A Byrnes, Fiona Cathcart, Sanjay H Chotirmall, Rebecca Cosgriff, Irmgard Eichler, Isabelle Fajac, Christopher H Goss, Pavel Drevinek, Philip M Farrell, Anna M Gravelle, Trudy Havermans, Nicole Mayer-Hamblett, Nataliya Kashirskaya, Eitan Kerem, Joseph L Mathew, Edward F McKone, Lutz Naehrlich, Samya Z Nasr, Gabriela R Oates, Ciaran O'Neill, Ulrike Pypops, Karen S Raraigh, Steven M Rowe, Kevin W Southern, Sheila Sivam, Anne L Stephenson, Marco Zampoli, Felix Ratjen
Journal: The Lancet Respiratory Medicine (2019)
Cyclic 3′,5′-adenosine monophosphate in human blood platelets. II. Effect of N6-2′-o-dibutyryl cyclic 3′,5′-adenosine monophosphate on platelet function
Journal: Journal of Clinical Investigation (1972)

In Volume 50, No. 1 p. 131, left column, fourth line from bottom for 10-11) mole cyclic AMP per min per 1010 platelets.The read 10-11) mole cyclic AMP per min per 109
Glyphosate Results Revisited
Authors: Donna R. Farmer, Timothy L. Lash, John F. Acquavella
Journal: Environmental Health Perspectives (2005)

Arsenic on the Hands of Children Kwon et al. (2004) reported significantly elevated dislodgeable soluble arsenic loads on (one or both?) hands of children following play on structures treated with chromated copper arsenate (CCA) but then concluded that the observed difference is unimportant:With a safe conservative assumption that all the arsenic on children's hands is ingested, the measured value is below the estimated average daily intake of inorganic arsenic from water and food ….
Diabetes and Employment
Journal: Diabetes Care (2008)

As of 2007, approximately 23.6 million Americans have diabetes (1), most of whom are or wish to be participating members of the workforce.Diabetes usually has no impact on an individual's ability to do a particular job, and indeed an employer may not even know that a given employee has diabetes.In 1984, the American Diabetes Association adopted the following position on employment:Any person with diabetes, whether insulin [treated] or non-insulin [treated], should be eligible for any employment for which he/she is otherwise qualified.
Errata
Journal: BMJ (1867)

BRITITH MEDICAL JO URYAL.533 even to delay it, and thus save the perineum.This! is a use of the forceps which I think has not been sufficiently dwelt upon, and which can only be satis.factorily accomplished by the long curved forceps.I repudiate the dogma, that force is never to be used in artificial delivery; in employing it judiciously we imitate nature herself, and it is only when abused that it becomes dangerous.I have over and over again verified in practice that, with proper precaution, and with appropriate manipulation, delivery may be
Massachusetts Medical Society
Authors: Frank N. Allan
Journal: New England Journal of Medicine (1977)

Dr. Frank N. Allan, internationally known physician in the field of diabetes, died on July 12, 1977. Born in Proton, Ontario, December 26, 1899, he graduated in medicine from the University of Toronto in 1922 and, in 1928, received the higher-thesis degree of M.D. cum laude. His thesis was on carbohydrate metabolism and diabetes and won the Starr Silver Medal. Dr. Allan was a senior medical student when 14-year-old Leonard Thompson was admitted to his ward. Leonard was the first patient ever to receive insulin for diabetes. Thus began a lifelong dedication to the study and treatment of this . . .
AMINO ACID—GLYCINE—THERAPY IN THE MYOPATHIES
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinicopathologic and Genotypic Features of Lung Adenocarcinoma Characterized by the International Association for the Study of Lung Cancer Grading System
Authors: Ryo Fujikawa, Yuji Muraoka, Jumpei Kashima, Yukihiro Yoshida, Kimiteru Ito, Hirokazu Watanabe, Masahiko Kusumoto, Shun-ichi Watanabe, Yasushi Yatabe
Journal: Journal of Thoracic Oncology (2022)
European Organization for Research on Treatment of Cancer Symposium on Gastrointestinal Tract Cancer—Update on Combined Modality Therapy
Journal: JNCI Journal of the National Cancer Institute (1985)

European Organization for Research on Treatment of Cancer Symposium on Gastrointestinal Tract Cancer—Update on Combined Modality Therapy Get access JNCI: Journal of the National Cancer Institute, Volume 75, Issue 6, December 1985, Page 1148, https://doi.org/10.1093/jnci/75.6.1148-c Published: 01 December 1985
Medical News
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal