tbuckley/cabot-search huggingface dataset:
Serum urea concentrations
Authors: C. Cohn
Journal: JAMA (1966)

From a historical viewpoint, urea is the first organic compound to have been synthesized by man in vitro; physiologically, by contrast, urea is the "last" one to be formed by him in vivo after a protein meal. Thus in the mammal, urea is the chief end product of protein metabolism, comprising some 80% of the non-protein nitrogen normally excreted in the urine per 24 hours.<sup>1</sup> Urea is generated in the liver as the end product of the activity of the first enzymatic cycle to have been described by Krebs, the ornithine-arginine-urea cycle.<sup>2</sup>Amino acids, derived from dietary protein or from peripheral tissues, consequent to the interchange of serum (dietary) and tissue amino acids, serve as the precursors fed into the enzymatic "degradation" process. The rate of urea formation is determined by the quantity of amino acids presented to the liver per unit of time. Accordingly, urea synthesis is
Three simple factors for rapid initial risk assessment in ST-elevation MI: An inTIME II substudy David A. Morrow, Elliott M. Antman, Robert P. Giugliano, Richard Cairns, Andrew Charlesworth, Sally S. Cutler, Carolyn H. McCabe, Eugene Braunwald. Brigham &amp; Women's Hospital, Boston, MA
Journal: Journal of the American College of Cardiology (2001)
Noninvasive Testing for Silent Myocardial Ischemia in Stable Coronary Patients-Reply
Authors: Robert E. Goldstein
Journal: JAMA (1993)

<h3>In Reply.</h3> —The letters of Leppo et al and Thompson emphasize that the purpose and methods of a clinical study are crucial in defining the meaning of that study's findings. When planning our study, we were impressed that considerable uncertainty exists regarding the clinical significance of silent myocardial ischemia in stable coronary patients. To address this uncertainty, we chose to study an intermediate-risk coronary population, ie, those who are clinically stable several months after an acute coronary event but are at risk for recurrent coronary events. This group of patients is frequently evaluated by noninvasive testing for evidence of myocardial ischemia prior to return to work or full activity, with the implication that the detection of myocardial ischemia has important prognostic implications. We observed myocardial ischemia in 41% of the study patients by stress thallium-201 scintigraphy, in 29% by exercise ECG, and in 8% by ambulatory ECG. The 2-year event
The PARTNERS program: Knowledge base and intensity of peripheral arterial disease detection in community practice Mary M. McDermott, Alan T. Hirsch, Michael H. Criqui, Judith G. Regensteiner, M. Eileen Walsh, Diane Treat-Jacobson, Susan Krook, Jeffrey W. Olin, Anthony J. Comerota, Emile R. Mohler, III, Mark A. Creager, William R. Hiatt. Northwestern University, Chicago, IL
Journal: Journal of the American College of Cardiology (2001)
Answer
Authors: W-J Lee, K-L Liu, S-J Chen
Journal: Thorax (2007)

in preserving lung tissue. 5In about 15% cases of acute pulmonary embolism, the collateral supply by bronchial arteries is insufficient.Pulmonary infarcts may be observed several hours later. 4he small air bubbles in the superior vena cava may originate from intravenous contrast media injection during CT scan and round pneumonia is a reasonable diagnosis of pulmonary opacities in this case.
Leads from the MMWR
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tremor
Authors: Peter Pereira
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aspirin curbs MIs in unstable angina cases
Authors: P. Gunby
Journal: JAMA (1983)

Aspirin appears to protect against acute myocardial infarction (MI) in men with unstable angina, according to Veterans Administration (VA) researchers. They base their conclusion on results of a randomized, double-blind, placebo-controlled study of 1,266 men with unstable angina, seen between 1974 and 1981 at 12 VA hospitals. Of these, 625 took 324 mg of aspirin in a buffered liquid solution (Alka Seltzer) daily for 12 weeks. The remaining 641 received a placebo in liquid form. H. Daniel Lewis, Jr, MD, chief of cardiology at the Kansas City, Mo, VA medical center and principal investigator, told an American Heart Association (AHA) audience in Dallas that the death rate from acute MI among the aspirin-treated patients during the treatment period was 51% lower (ten deaths, 1.6%) than for the placebo group (21 deaths, 3.3%). The rate of nonfatal acute MIs during the study period also was lower for the aspirin therapy group
Incorrect Spelling of Author’s Last Name
Authors: Harriette Van Esch, Lia Van Zuylen, Carin Van Der Rijt
Journal: JAMA (2022)

In the Letter to the Editor titled “A Review of Chronic Pelvic Pain in Women,”1 published in the December 7, 2021, issue of JAMA, the second author’s last name was misspelled. In the byline, “Apurva Shrigirwar, MD,” should have been “Apurva Shrigiriwar, MD.” This article was corrected online.
Baby Check does not reduce GP consultation rate
Journal: BMJ (1999)

Women should be advised to allow adequate time after stillbirth before next pregnancy Some clinicians have argued that women need time to recover emotionally after stillbirth and before beginning the next pregnancy, but without systematic evidence to support this.In a cohort study (p 1721) Hughes et al found that in the pregnancy after stillbirth women showed significantly higher depression and state anxiety in the third trimester than control women, and that the difference was accounted for by women who conceived within 12 months after the stillbirth.These women were also more depressed 1 year after the next birth.Women who conceived more that 12 months after stillbirth were similar to their controls at all points.Women may need a year to recover after stillbirth-or perhaps those who become pregnant quickly are more vulnerable to depression and anxiety.
La Peste Bubonique dans la Republique Argentine et au Paraguay Epidémies de 1899-1900.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
High-Definition Colonoscopy Compared With Cuff- and Cap-Assisted Colonoscopy: Results From a Multicenter, Prospective, Randomized Controlled Trial
Authors: Madhav Desai, Douglas K Rex, Matthew E Bohm, Perica Davitkov, John M DeWitt, Monika Fischer, Gregory Faulx, Ryan Heath, Timothy D Imler, Toyia N James-Stevenson, Charles J Kahi, William R Kessler, Divyanshoo R Kohli, Lee McHenry, Tarun Rai, Nicholas A Rogers, Sashidhar V Sagi, Anjana Sathyamurthy, Prashanth Vennalaganti, Suneha Sundaram, Harsh Patel, April Higbee, Kevin Kennedy, Rachel Lahr, Gjorgie Stojadinovikj, Chandra Dasari, Sravanthi Parasa, Ashley Faulx, Prateek Sharma
Journal: Clinical Gastroenterology and Hepatology (2021)
Is the need for re-intervention higher with percutaneous coronary interventions or with coronary artery bypass surgery? Gishel New, Issam Moussa, Vickram Veeramachaneni, Roxana Mehran, George Dangas, Alexandra Lansky, Milena Adamian, Gary S. Roubin, Michael B. Collins, Edward Kreps, Sriram S. Iyer, Martin B. Leon, Valavanur Subramanium, Mark Connelly, Jeffrey W. Moses. Lenox Hill Heart and Vascular Institute of New York, New York, NY
Journal: Journal of the American College of Cardiology (2001)
Bleeding Stigmata
Authors: F. J. Brown
Journal: BMJ (1871)

THE BRIT SR MEDICAL _OURANAL.[May 20, 187I.in the following way.A patient is rolled into the arena from the ad- joining ward on a bed, and one of the students, named Practicanten, who have put their names on a list for the purpose, is called down.The hiistory of the case is read to him and to the class, and he makes a physical examination of the patient, assisted by the professor, and then forms his diagnosis.The professor then analyses the case in every
THE RELATION OF THE HYPOPHYSIS CEREBRI TO ACROMEGALY.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 17317: Differential Coupling and Regulation of GIRK-Dependent Muscarinic and Adenosine Receptor Signaling in Mouse Sino-Atrial Nodal Cells
Authors: Allison Anderson, Kevin Wickman
Journal: Circulation (2018)

Introduction and Hypothesis: Parasympathetic slowing of heart rate is largely mediated by muscarinic receptor (M2R) activation of the G protein gated inwardly-rectifying potassium (GIRK) channel on sinoatrial-nodal (SAN) cells and atrial myocytes. The strength of M2R-GIRK signaling is negatively regulated by regulator of G protein signaling 6, RGS6. Genetic ablation of RGS6 in mice gives rise to enhanced M2R-GIRK signaling in SAN cells, resulting in both exaggerated M2R-induced bradycardia and increased susceptibility to pacing-induced atrial fibrillation. Adenosine receptor (A1R) activation, which can provoke atrial arrhythmias in human patients, can also activate GIRK channels, however, the details of A1R-GIRK signaling are poorly understood. Here, we investigated A1R-GIRK signaling in mouse SAN cells and tested the hypothesis that RGS6 negatively regulates A1R-GIRK signaling. Methods and Results: Using whole-cell patch-clamp electrophysiology, we measured the efficacy and potency of M2R- and A1R- GIRK signaling in adult SAN cells from wildtype and Rgs6 -/- mice. We found SAN cells from Rgs6 -/- mice displayed both prolonged channel deactivation kinetics and increased channel sensitivity to CCh-induced currents as compared to wild-type SAN cells. Surprisingly, we found no difference in kinetics or channel sensitivity of A1R-GIRK responses in Rgs6 -/- SAN cells. We did observe, however, a striking, significant increase in the amplitude of the A1R-GIRK response in Rgs6 -/- SAN cells compared to wild-type controls. Furthermore, occlusion studies in wild-type SAN cells suggest that M2R activates nearly all of the GIRK channels present in SAN cells, while A1R activation results in only partial GIRK channel activation. Intriguingly, RGS6 ablation seems to allow a larger proportion of GIRK channels to be activated by A1R. Recordings from mice lacking cardiac GIRK channels confirm that M2R- and A1R- induced currents are GIRK-dependent. Conclusions: Our results suggest that M2R-GIRK and A1R-GIRK are coupled differently within mouse sino-atrial nodal cells, resulting in differential regulation by RGS6.
Walking forwards, looking backwards
Authors: None The Lancet Planetary Health
Journal: The Lancet Planetary Health (2020)

Scanning back over news headlines from this year throws up a lot of references to events being unprecedented and unexpected and to many societal responses as being relatively underprepared, unplanned, or poorly tested, especially where multiple stressors overlap. Indeed, if we lacked useful and meaningful foresight and could only learn from past experience, then that would be our inevitable predicament. 2020 has been remarkable in many respects to the extent that even listing the examples would take up most of the available space for this editorial.
Physicians' Liability Will Continue To Increase, Says Institute Speaker
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Osteogenesis imperfecta
Authors: Joan C. Marini, Antonella Forlino, Hans Peter Bächinger, Nick J. Bishop, Peter H. Byers, Anne De Paepe, Francois Fassier, Nadja Fratzl-Zelman, Kenneth M. Kozloff, Deborah Krakow, Kathleen Montpetit, Oliver Semler
Journal: Nature Reviews Disease Primers (2017)
Breaking the technical barrier of microvascular anastomosis with high-speed videography: A prospective cohort study
Authors: Bingbo Bao, Tao Gao, Xingwei Li, Haifeng Wei, Junqing Lin, Yi Sun, Junjie Shen, Hongyi Zhu, Xianyou Zheng
Journal: International Journal of Surgery (2022)

Microsurgical anastomosis is technically difficult especially for less-experienced surgeons. Traditionally, surgeons in training could only accomplish these surgeries under intensive guiding and supervision from senior surgeons. This study presents and characterises a new method for microsurgical trainees to objectively evaluating the quality of vascular anastomosis intraoperatively.We conducted a prospective study to determine the utility of patency test of vascular anastomosis with assistance of high-speed video recording (PTHVR) to evaluate the quality of vascular anastomosis during microsurgery. To determine whether the use of PTHVR outperformed traditional supervision from senior surgeons (historical control), we compared the outcomes of microsurgeries including free flap transfer and replantation between the two groups.A total of 211 patients were enrolled, of which 98 underwent surgery under traditional supervision and 113 underwent surgery with PTHVR. Of the 211 patients, 102 underwent digit replantation (48%), 22 underwent limb replantation (10%), and 87 underwent free flap transfer (42%). There was no statistical difference between the two groups in age, gender, BMI, pre-existing comorbidities, smoking status, alcohol consumption, and duration of surgery. Use of PTHVR as an intraoperative guide significantly decreased the rate of re-exploration surgeries (PTHVR, 8.0% [9/113]; control, 23.5% [23/98]; P = 0.002) and replantation/free flap failures (PTHVR, 8.8% [10/113]; control, 19.4% [19/98]; P = 0.029) compared with historical control under traditional supervision.PTHVR is a useful tool for improving the success rate of microsurgery for less-experienced surgeons when compared with traditional supervision mode.
Use of a Cytosponge biomarker panel to prioritise endoscopic Barrett's oesophagus surveillance: a cross-sectional study followed by a real-world prospective pilot
Authors: Nastazja Dagny Pilonis, Sarah Killcoyne, W Keith Tan, Maria O'Donovan, Shalini Malhotra, Monika Tripathi, Ahmad Miremadi, Irene Debiram-Beecham, Tara Evans, Rosemary Phillips, Danielle L Morris, Craig Vickery, Jon Harrison, Massimiliano di Pietro, Jacobo Ortiz-Fernandez-Sordo, Rehan Haidry, Abigail Kerridge, Peter D Sasieni, Rebecca C Fitzgerald
Journal: The Lancet Oncology (2022)
Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation Effect on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure—Reply
Authors: James J. McNamee, Daniel Brodie, Daniel F. McAuley
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 458: Moderate Exercise Training Attenuates Isoproterenol-Induced Myocardial Injury by Activating Nrf2-Signaling
Authors: Gobinath Shanmugam, Madhusudhanan Narasimhan, Robbie Conley, Rajesh Kumar Radhakrishnan, Silvio H Litovsky, Namakkal-Soorapppan Rajasekaran
Journal: Circulation Research (2017)

Background: Nuclear erythroid-2 like factor-2 (Nrf2), a master transcriptional regulator of antioxidants, is critical to maintain cellular redox homeostasis. We recently reported that exercise training activates Nrf2/antioxidant signaling in the heart. Isoproterenol (ISO) mediated structural, and functional changes in the heart involve oxidative stress. Here, we tested a hypothesis that moderate exercise training will protect the myocardium from isoproterenol-induced injury by augmenting Nrf2-dependent antioxidant defense system. Methods: Age- and sex-matched WT (C57/BL6) mice (6-8 months old) were subjected to moderate exercise training (MET) on a treadmill for 6 weeks (60 min/day; 10m/min; 0% grade). Randomly assigned untrained (UNT) and trained (MET) animals were intraperitoneally injected (at the start of 6 th week) with 50 mg of isoproterenol/kg.bw./day for 7 consecutive days. MET was continued during ISO administration and the animals (UNT + PBS, UNT + ISO; MET + ISO) underwent echocardiography analysis. Heart tissues were collected for histopathology, Nrf2-ARE promoter binding assay (Active-motif TransAM kit), antioxidant gene (qPCR) and protein (Immunoblotting) levels, and glutathione redox status. Results: ISO administration significantly reduced the Nrf2 promoter activity (p&lt;0.05) and downregulated the expression of cardiac antioxidant genes ( Gclc, Nqo1, Cat, Gsr and Gst-μ ) in UNT mice. Further, increased oxidative stress with severe myocardial injury was evident in UNT+ISO when compared to UNT mice receiving PBS under basal condition. Interestingly, MET stabilized the Nrf2-promoter activity and promoted the expression of Nrf2-dependent antioxidant genes and proteins animals receiving ISO, and thereby attenuated the oxidative stress-induced myocardial damage. Echocardiography analysis showed impaired systolic/diastolic ventricular volumes coupled with decreased cardiac output in UNT+ISO mice, but this was normalized in exercise-trained animals. Conclusion: Thus moderate exercise training conferred protection against ISO-induced myocardial injury by augmentation of Nrf2-antioxidant signaling and attenuation of redox perturbations.
Author Index
Authors: Harold Levitan, Robert C. Smith, G.C. Lyketsos, A. Karabetsos, J. Jordanoglou, T. Liokis, A. Armagianidis, C.G. Lyketsos, Nancy L. Hutner, Steven E. Locke, Reinhold Schwarz, Siegfried Geyer, James Georgas, Eliza Giakoumaki, Nikos Georgoulias, Eugene Koumandakis, Dionysios Kaskarelis
Journal: Psychotherapy and Psychosomatics (1984)