tbuckley/cabot-search huggingface dataset:
Birth Outcomes of Neonates Exposed to Marijuana in Utero
Authors: Greg Marchand, Ahmed Taher Masoud, Malini Govindan, Kelly Ware, Alexa King, Stacy Ruther, Giovanna Brazil, Hollie Ulibarri, Julia Parise, Amanda Arroyo, Catherine Coriell, Sydnee Goetz, Amitis Karrys, Katelyn Sainz
Journal: JAMA Network Open (2022)

<h3>Importance</h3> While some studies have found an association between marijuana use and adverse neonatal outcomes, results have not been consistent across all trials. <h3>Objective</h3> To assess available data on neonatal outcomes in marijuana-exposed pregnancies. <h3>Data Sources</h3> PubMed, Medline, ClinicalTrials.gov, Cochrane, Scopus, and Web of Science were searched from each database's inception until August 16, 2021. <h3>Study Selection</h3> All interventional and observational studies that included pregnant women who were exposed to marijuana compared with pregnant women who were not exposed to marijuana and that reported neonatal outcomes were included. <h3>Data Extraction and Synthesis</h3> Reporting followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses guideline. Data were extracted by 2 authors for all outcomes, which were pooled using a random-effects model as mean difference or risk ratio (RR) and 95% CI. Data were analyzed from August through September 2021. <h3>Main Outcomes and Measures</h3> All outcomes were formulated prior to data collection. Outcomes included incidence of birth weight less than 2500 g, small for gestational age (defined as less than the fifth percentile fetal weight for gestational age), rate of preterm delivery (defined as before 37 weeks' gestation), gestational age at time of delivery, birth weight, incidence of neonatal intensive care unit (NICU) admission, Apgar score at 1 minute, Apgar score at 5 minutes, incidence of an Apgar score less than 7 at 5 minutes, fetal head circumference, and fetal length. <h3>Results</h3> Among 16 studies including 59 138 patients, there were significant increases in 7 adverse neonatal outcomes among women who were exposed to marijuana during pregnancy vs those who were not exposed during pregnancy. These included increased risk of birth weight less than 2500 g (RR, 2.06 [95% CI, 1.25 to 3.42];<i>P</i> = .005), small for gestational age (RR, 1.61 [95% CI, 1.44 to 1.79];<i>P</i> &lt; .001), preterm delivery (RR, 1.28 [95% CI, 1.16 to 1.42];<i>P</i> &lt; .001), and NICU admission (RR, 1.38 [95% CI, 1.18 to 1.62];<i>P</i> &lt; .001), along with decreased mean birth weight (mean difference, −112.30 [95% CI, −167.19 to −57.41] g;<i>P</i> &lt; .001), Apgar score at 1 minute (mean difference, −0.26 [95% CI, −0.43 to −0.09];<i>P</i> = .002), and infant head circumference (mean difference, −0.34 [95% CI, −0.63 to −0.06] cm;<i>P</i> = .02). <h3>Conclusions and Relevance</h3> This study found that women exposed to marijuana in pregnancy were at a significantly increased risk of some adverse neonatal outcomes. These findings suggest that increasing awareness about these risks may be associated with improved outcomes.
SOCIETY NEWS.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Interstate Measles Transmission From a Ski Resort—Colorado, 1994
Journal: JAMA (1994)

During April 1-May 25, 1994, a chain of measles transmission began in Breckenridge, Colorado, and extended into nine additional states; a total of 247 measles cases were reported, representing 36% of all U.S. measles cases reported to the National Notifiable Diseases Surveillance System (excluding those reported from U.S. territories) through July 2 (week 26). The source of exposure was unknown but is believed to have been an out-of-state tourist who probably visited Breckenridge during March because 1) no measles cases had previously been reported in Colorado during 1994, and 2) the only common exposure appeared to have been at a ski resort visited by many out-of-state travelers. Persons associated with spread of measles from Breckenridge were predominantly school- and college-aged. This report summarizes the investigation of this chain of interstate measles transmission.
Discontinuing Medications Used To Prevent <i>Pneumocystis carinii</i> Pneumonia in Patients with HIV Infection
Journal: Annals of Internal Medicine (2000)

Summaries for Patients1 February 2000Discontinuing Medications Used To Prevent Pneumocystis carinii Pneumonia in Patients with HIV InfectionSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-3-200002010-00031 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Pneumocystis carinii pneumonia (PCP) is a type of lung infection that can occur in persons infected with the AIDS virus, HIV. Experts recommend that HIV-infected persons who do not have enough of a certain white blood cell (CD4 cells, with counts below 200) take medications that can prevent PCP. The CD4 count provides an indication of how severely the HIV infection has affected a person's immune system. Highly active antiretroviral therapies (HAART) are newer drug regimens that are very effective at treating HIV infection and raising CD4 counts. ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Discontinuation of Chemoprophylaxis against Pneumocystis carinii Pneumonia in Patients with HIV Infection.” It is in the 1 February 1999 issue of Annals of Internal Medicine (volume 132, pages 201-205). The authors are B.G. Yangco, J.C. Von Bargen, A.C. Moorman, and S.D. Holmberg, for the HIV Outpatient Study (HOPS) Investigator.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDiscontinuation of Chemoprophylaxis against Pneumocystis carinii Pneumonia in Patients with HIV Infection Bienvenido G. Yangco , Jennifer C. Von Bargen , Anne C. Moorman , Scott D. Holmberg , and Metrics 1 February 2000Volume 132, Issue 3Page: 201KeywordsDrug therapyHIVHIV infectionsHighly active antiretroviral therapyImmune systemLungsOutpatientsPneumocystis carinii pneumoniaPneumocystis jiroveci pneumoniaWhite blood cells ePublished: 15 August 2000 Issue Published: 1 February 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.Loading ...
INSOMNIA FOLLOWING ACUTE EPIDEMIC (LETHARGIC) ENCEPHALITIS IN CHILDREN
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vision
Authors: Bonnie Salomon
Journal: Annals of Internal Medicine (2004)

Ad Libitum6 January 2004VisionBonnie Salomon, MDBonnie Salomon, MDFrom Lake Forest Hospital, Lake Forest, IL 11733.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-1-200401060-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Your eyes adjust.Just as in a dark roomShapes clarify to named things,Familiar things, a chair, a table, a lamp.The bruises on a child's thigh revealNo simple accident, but betrayal.The scars on arms tell of self-abuseWith needle pricks in hope of a high.The nervous smile of the teenagerWho took Daddy's car before the crash—Without permission.The bravery of a wife ... Author, Article, and Disclosure InformationAffiliations: From Lake Forest Hospital, Lake Forest, IL 11733.Current Author Address: Bonnie Salomon, MD, Emergency Department, Lake Forest Hospital, 660 North Westmoreland, Lake Forest, IL 60045. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 6 January 2004Volume 140, Issue 1Page: 65KeywordsAdolescentsEmergency departmentInterleukinsScarsVision ePublished: 6 January 2004 Issue Published: 6 January 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
OF BOOKS
Journal: JAMA (1964)

During the 16th and 17th centuries, when rebellion against tradition and authority was especially acute, the framework of our modern world took shape. Yet despite all changes the hand of the past was by no means dead. The great body of classical learning, for example, that had become important during the Renaissance, exerted a powerful counterattraction against any newer trend. Those who adhered to the classical traditions maintained that the old ways were still the best. From the tensions between the old and the new there arose an intellectual struggle, often called the battle of the ancients and the moderns. Those who upheld the "ancients" pointed to the glories of classical literature and philosophy, unequalled in modern times. Their opponents countered by indicating the growth of science and the great technological discoveries of recent centuries which, so went the claim, brought superiority to the "modern" camp. Three specific discoveries were
Evaluation of a new hypnotic agent: flurazepam hydrochloride (dalmane)
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pediatrics, Springfield, Ill
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Baseline Clinical and Immunologic Characteristics of Children Screened in the Peanut Oral Immunotherapy Study of Early Intervention for Desensitization (POSEIDON) Trial
Authors: Brian Vickery, George du Toit, Anoshie Ratnayake, Katharina Blumchen, Vibha Sharma, John Chapman, Antoine Deschildre, Lawrence Sher, David Norval, Daniel Adelman, Kirsten Beyer, Thomas Casale, Alexander Greiner, Amanda Cox, Rachel Robison, Kari Brown, Amy Scurlock
Journal: Journal of Allergy and Clinical Immunology (2022)
Axial alignment is a critical regulator of knee osteoarthritis
Authors: Tamás Oláh, Jan Reinhard, Matthias W. Laschke, Lars K. H. Goebel, Frédéric Walter, Gertrud Schmitt, Susanne Speicher-Mentges, Michael D. Menger, Magali Cucchiarini, Dietrich Pape, Henning Madry
Journal: Science Translational Medicine (2022)

Although osteoarthritis (OA), a leading cause of disability, has been associated with joint malalignment, scientific translational evidence for this link is lacking. In a clinical case study, we provide evidence of osteochondral recovery upon unloading symptomatic isolated medial tibiofemoral knee OA associated with varus malalignment. By mapping response correlations at high resolution, we identify spatially complex degenerative changes in cartilage after overloading in a clinically relevant ovine model. We further report that unloading diminishes OA cartilage degeneration and alterations of critical parameters of the subchondral bone plate in a similar topographic fashion. Last, therapeutic unloading shifted the articular cartilage and subchondral bone phenotype to normal and restored several physiological correlations disturbed in neutral and varus OA, suggesting a protective effect on the integrity of the entire osteochondral unit. Collectively, these findings identify modifiable trajectories with considerable translational potential to reduce the burden of human OA.
Bioorthogonally Cross‐Linked Hyaluronan–Laminin Hydrogels for 3D Neuronal Cell Culture and Biofabrication
Authors: Michael Jury, Isabelle Matthiesen, Fatemeh Rasti Boroojeni, Saskia L. Ludwig, Livia Civitelli, Thomas E. Winkler, Robert Selegård, Anna Herland, Daniel Aili
Journal: Advanced Healthcare Materials (2022)

Laminins (LNs) are key components in the extracellular matrix of neuronal tissues in the developing brain and neural stem cell niches. LN-presenting hydrogels can provide a biologically relevant matrix for the 3D culture of neurons toward development of advanced tissue models and cell-based therapies for the treatment of neurological disorders. Biologically derived hydrogels are rich in fragmented LN and are poorly defined concerning composition, which hampers clinical translation. Engineered hydrogels require elaborate and often cytotoxic chemistries for cross-linking and LN conjugation and provide limited possibilities to tailor the properties of the materials. Here a modular hydrogel system for neural 3D cell cultures, based on hyaluronan and poly(ethylene glycol), that is cross-linked and functionalized with human recombinant LN-521 using bioorthogonal copper-free click chemistry, is shown. Encapsulated human neuroblastoma cells demonstrate high viability and grow into spheroids. Long-term neuroepithelial stem cells (lt-NES) cultured in the hydrogels can undergo spontaneous differentiation to neural fate and demonstrate significantly higher viability than cells cultured without LN. The hydrogels further support the structural integrity of 3D bioprinted structures and maintain high viability of bioprinted and syringe extruded lt-NES, which can facilitate biofabrication and development of cell-based therapies.
Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin
Authors: Muthiah Vaduganathan, Naveed Sattar, Jialin Xu, Javed Butler, Kenneth W Mahaffey, Bruce Neal, Wayne Shaw, Norman Rosenthal, Michael Pfeifer, Michael K Hansen, James L Januzzi
Journal: Journal of the American College of Cardiology (2022)
Most of healthcare budget is spent on care not cure
Journal: BMJ (1998)

Recovery is quicker after laparoscopic hernia repair-but there is a cost Repair of inguinal hernias is one of the most common surgical procedures.Surgeons are increasingly using a preformed synthetic mesh to cover the inguinal defect.On p 103 Wellwood et al evaluate the costs and outcomes (both clinical and patient based) of open and laparoscopic mesh repair in a randomised controlled trial of 400 patients.Patients undergoing laparoscopic hernia repair recovered faster and experienced less pain than patients who underwent standard open mesh repair.The laparoscopic procedure, however, was more costly.
Results of the United States Food and Drug Administration Clinical Trial of the CustomFlex Artificial Iris
Authors: Brandon D. Ayres, Barbara S. Fant, Zachary C. Landis, Kevin M. Miller, R. Doyle Stulting, Robert J. Cionni, Nicole R. Fram, Stephen Hamilton, David R. Hardten, Douglas D. Koch, Samuel Masket, Francis W. Price, Kenneth J. Rosenthal, M. Bowes Hamill, Michael E. Snyder
Journal: Ophthalmology (2022)
THE PUBLIC REALIZATION OF THE NOSTRUM EVIL.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Programmed Death-Ligand 1 Copy Number Loss in NSCLC Associates With Reduced Programmed Death-Ligand 1 Tumor Staining and a Cold Immunophenotype
Authors: Savreet Aujla, Christian Aloe, Amanda Vannitamby, Shona Hendry, Kanishka Rangamuwa, Hao Wang, Ross Vlahos, Stavros Selemidis, Tracy Leong, Daniel Steinfort, Steven Bozinovski
Journal: Journal of Thoracic Oncology (2022)

Programmed death-ligand 1 (PD-L1) copy number gains may be predictive of clinical response to immunotherapy in NSCLC. This study investigated PD-L1 copy number variations in tumor resection and bronchoscopy biopsies and its relationship with PD-L1 tumor cell staining and inflammatory gene expression.PD-L1 gene copy number and mRNA expression were evaluated by real-time polymerase chain reaction in surgically resected NSCLC tumor biopsies (n = 87) and control biopsies (n = 20). A second cohort (n = 15) of bronchoscopy-derived tumor biopsies was analyzed, including multiple biopsies from the same patient across different anatomical sites.PD-L1 mRNA levels strongly correlated with PD-L1 tumor staining (r = 0.55, p < 0.0001). Interferon-γ mRNA expression associated with PD-L1 immune cell staining, but not PD-L1 tumor cell staining. In contrast, PD-L1 copy number positively associated PD-L1 tumor staining, but not PD-L1 immune cell staining. PD-L1 copy number analysis detected loss (15 of 87 = 17%) and gain (5 of 87 = 7%) of copy number. Tumors with low PD-L1 copy number expressed significantly reduced levels of inflammatory (interferon-γ, interleukin [IL]-6, IL-1β, MMP-9) and immunosuppressive (IL-10, transforming growth factor β) mediators. Analysis of bronchoscopy-derived biopsies revealed low heterogeneity in copy number values across different anatomical sites, in contrast to more variable PD-L1 mRNA expression.Low PD-L1 copy number tumors display reduced PD-L1 expression, reduced PD-L1 tumor cell staining, and an immunologic cold tumor microenvironment. Because PD-L1 copy number values are highly stable across different tumor regions, its evaluation may represent a robust and complimentary biomarker for predicting response to immunotherapy, where low copy number may predict lack of response.
Species-resolved sequencing of low-biomass or degraded microbiomes using 2bRAD-M
Authors: Zheng Sun, Shi Huang, Pengfei Zhu, Lam Tzehau, Helen Zhao, Jia Lv, Rongchao Zhang, Lisha Zhou, Qianya Niu, Xiuping Wang, Meng Zhang, Gongchao Jing, Zhenmin Bao, Jiquan Liu, Shi Wang, Jian Xu
Journal: Genome biology (2022)

Abstract Microbiome samples with low microbial biomass or severe DNA degradation remain challenging for amplicon-based or whole-metagenome sequencing approaches. Here, we introduce 2bRAD-M, a highly reduced and cost-effective strategy which only sequences ~ 1% of metagenome and can simultaneously produce species-level bacterial, archaeal, and fungal profiles. 2bRAD-M can accurately generate species-level taxonomic profiles for otherwise hard-to-sequence samples with merely 1 pg of total DNA, high host DNA contamination, or severely fragmented DNA from degraded samples. Tests of 2bRAD-M on various stool, skin, environmental, and clinical FFPE samples suggest a successful reconstruction of comprehensive, high-resolution microbial profiles.