tbuckley/cabot-search huggingface dataset:
Gene expression profiles that predict response to platinum and identify patterns of pathway deregulation in advanced ovarian cancer
Authors: J. M. Lancaster, A. Bild, J. Pittman, R. Sayer, R. S. Whitaker, J. Marks, W. Mike, H. Dressman, J. Nevins, A. Berchuck
Journal: Journal of Clinical Oncology (2005)

5031 Background: Platinum drugs are the most active agents in epithelial ovarian cancer, however 30% of patients with advanced disease have an incomplete response. Current treatment strategies result in many patients receiving multiple cycles of platinum-based chemotherapy without complete response. We have developed gene expression profiles that predict response to platinum therapy, with the aim of individualizing therapy. In parallel, we identified patterns of oncogenic pathway deregulation within the non-responding patient group that provides a rational basis for directing targeted therapeutics. Methods: Affymetrix GeneChips were used to measure gene expression in 120 stage III/IV serous ovarian cancers from patients who underwent primary surgical cytoreduction followed by platinum therapy. Expression data was compared between cancers that demonstrated a complete and incomplete response to platinum therapy. Predictive models were developed to distinguish patients likely to respond to therapy. In addition, gene expression profiles previously developed to reflect the status of oncogenic signaling pathways, including Ras, Src, Rb, β-catenin, and Myc, were used to assess the state of these pathways within the cancers. Results: Predictive models were found to accurately distinguish patients with respect to response to platinum therapy in both leave-one-out cross validation and distinct training/validation sample sets. The model comprises 64 genes including FADD and decorin, both of which have been shown to be directly involved in the action of carboplatin. The application of profiles that predict pathway status identified cancers that exhibited co-deregulation of Src and β-catenin that were associated with extremely poor prognosis (4 year survival of 28%). The majority of platinum non-responders fell into this sub-group. Conclusions: Gene expression profiles can accurately predict response to platinum-based chemotherapy for advanced stage serous ovarian cancers, and may be used to tailor therapy in the future. Further, the use of pathway predictions may provide an opportunity to direct the use of targeted therapeutics to patients unlikely to respond to platinum. No significant financial relationships to disclose.
Abstract 17792: Relation of Complications to Phenotypic Characteristics in Bicuspid Aortic Valve Disease: A Single Center Experience
Authors: Serdar M Kucukoglu, Okay Abaci, Cüneyt Kocas, Kadriye Kiliçkesmez, ümit Y Sinan, Polat I Canbolat, Sinan üner
Journal: Circulation (2013)

Background: A congenital bicuspid aortic valve (BAV) is the commonest cardiac defect, occurring in 0.5-2% of the general population. It is often associated with cardiac events such as; valvular dys...
NICE to advise firms on how to speed up NHS adoption of their drugs
Authors: N. Hawkes
Journal: BMJ (2015)

The UK National Institute for Health and Care Excellence (NICE) is to set up a new Office of Market Access to advise companies producing new drugs on how to speed up their adoption by the NHS.

The decision, discussed at a NICE board meeting on 20 May, was outlined on 21 May at a Westminster Forum seminar on healthcare research by Carole Longson, NICE’s director of health technology evaluation. Research was the key to generating new drugs, she said, and moves to accelerate the adoption of new products were being encouraged by regulators in the form of early access schemes, where drugs may be approved on much less evidence than in the past.

In this new environment, she asked, “Is NICE sending the right signals to the research environment, and are we doing it in a way that can be picked up?” She answered her own question by admitting, “Well, I think we can do …
Abstract 3442: Pattern and Time Path of Neonintimal Healing in Drug Eluting versus Bare Metal Stents in the Rat Aortic Stent Model
Authors: Hendrik C Groenewegen, Anton J Roks, Maaike Goris, Felix Zijlstra, Wiek H van Gilst, Bart J de Smet
Journal: Circulation (2007)

Purpose:to determine if the neointima of drug-eluting stents is histological different from their bare metal controls. Neointimal formation in stented aortas was evaluated quantatively and qualitatively at two time points. Methods:male Wistar rats were randomized to one of four groups: Express 2 stent , Taxus Express 2 stent , Bx Velocity stent and Cypher stent. Stents were implanted in the abdominal aorta. Histological analyses were performed after 1 and 4 weeks. After 1 week the inflammation score and neointimal cell density was measured. Stented aortas were also examined for acellularity of neointima and /or the presence of a hemorrhage in the neointima. After 4 weeks the same measurements were performed plus the neointimal area and neointimal thickness. Results:no differences were observed after 1 week between bare metal stents and drug-eluting stents. At 4 weeks neointimal cell density was lower and inflammation-score was higher in the drug eluting stents. Furthermore in less than 10% of the bare metal stents acellularity of neointima and/or hemorrhage was found. On the contrary, in more than 90% of the drug eluting stents acellularity of neointima and/or hemorrhage was seen. Neointima area and neointimal thickness was reduced in the drug-eluting stents. No histological differences were found between the paclitaxel and the sirolimus eluting stent. Conclusions:Both drug eluting stents are effective in reducing neointimal formation however in both drug eluting stents acellular areas were observed in the neointima of almost every single stent. This is likely to be a reflection of incomplete healing which persists after neointimal formation has peaked. Table 1. Histological measurements: results in the 4 week groups.
Investigations and control measures following a case of inhalation anthrax in East London in a drum maker and drummer, October 2008
Authors: S Anaraki, S Addiman, G Nixon, D Krahé, R Ghosh, T Brooks, G Lloyd, R Spencer, A Walsh, B McCloskey, N Lightfoot
Journal: Eurosurveillance (2008)

The patient is believed to have acquired the infection from making animal hide drums. Environmental investigations identified one drum and two pieces of animal skins contaminated with anthrax spores.
For Which Glaucoma Suspects Is It Appropriate to Initiate Treatment?
Authors: E Cheng, J Giaconi, A Coleman, B Lee, R Weinreb, S Newberry, M Suttorp, M Schonlau, M Fingeret, N Gupta, R Hitchings, H Jampel, T Lewis, S Miglior, R Mills, N Pfeiffer, F Topouzis, T Samuelson
Journal: Ophthalmology (2009)
Abstract 16065: Sex-Specific Benefits of Sirolimus Eluting Stent on Long Term Outcomes in Patients With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: Insights From the MULTISTRATEGY (Multicenter Evaluation of Single High-Dose Bolus Tirofiban Versus Abciximab With Sirolimus-Eluting Stent or Bare-Metal Stent in Acute Myocardial Infarction Study) Trial
Authors: Giuseppe Ferrante, Patrizia Presbitero, Gianluca Campo, Elena Corrada, Raul Moreno, Alfredo E Rodriguez, Leonardo Bolognese, Ezio Bramucci, Roberto Ferrari, Marco Valgimigli
Journal: Circulation (2011)

Background. There is no data on sex-specific differences in long term benefit of sirolimus eluting stent (SES) use compared to bare metal stent (BMS) use among patients undergoing primary percutane...
Abstract 2336: The Impact Of Age On The Measurement Of Left Ventricular Torsion, Radial And Circumferential Strain And Strain Rate By Two-dimensional Echocardiographic Speckle Tracking
Authors: Ken Takahashi, Ghassan Al-Naami, Akio Inage, Richard Thompson, Jeffrey F Smallhorn
Journal: Circulation (2007)

Background: Left ventricular (LV) torsion (LVtor) and strain (S) are important components of LV performance. However, there is a little information on the affect of age on these measurements. Metho...
Kursus der Psychotherapie und des Hypnotismus.
Authors: Georg Flatau
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nasal diamorphine in children with clinical fractures
Authors: G. Eva
Journal: BMJ (2001)

# Patients should be told what to do when analgesia wears off {#article-title-2} EDITOR—Kendall et al report the advantages of nasal diamorphine.1 When my 5 year old son was recently admitted to an accident and emergency department with a fractured collarbone, nasal diamorphine was administered with all of the good effects that the authors described. But the effects wear off quite quickly. In our case, diamorphine was administered at 6 am and my son was supplied with a piece of triangular cotton and discharged home. By 10 am he was in severe pain, and for the following 12 hours or so he was extremely distressed. The combination of ibuprofen and paracetamol prescribed by the hospital was not adequate. When I rang the general practitioner to request something more effective I was told that she could not help; if we had a problem we should take him back to hospital. Even had I been able to face another six hour wait in the accident and emergency department this was impossible—he screamed when he moved. We persevered at home and worked on distraction. Nasal diamorphine is evidently effective, safe, and easy to administer. I would appeal to doctors using it for children in accident and emergency departments, however, to make adequate provision for after its effects have worn off. 1. 1.↵1. Kendall JM, 2. Reeves BC, 3. Latter VS .Multicentre randomised controlled trial of nasal diamorphine for analgesia in children and teenagers with clinical fractures.BMJ2001;322: 261–265. (3 February.) [OpenUrl][1][Abstract/FREE Full Text][2] # Most interesting questions remain unanswered in this study {#article-title-4} EDITOR—We … [1]: {openurl}?query=rft.jtitle%253DBMJ%26rft.stitle%253DBMJ%26rft.issn%253D0007-1447%26rft.aulast%253DKendall%26rft.auinit1%253DJ.%2BM%26rft.volume%253D322%26rft.issue%253D7281%26rft.spage%253D261%26rft.epage%253D265%26rft.atitle%253DMulticentre%2Brandomised%2Bcontrolled%2Btrial%2Bof%2Bnasal%2Bdiamorphine%2Bfor%2Banalgesia%2Bin%2Bchildren%2Band%2Bteenagers%2Bwith%2Bclinical%2Bfractures%26rft_id%253Dinfo%253Adoi%252F10.1136%252Fbmj.322.7281.261%26rft_id%253Dinfo%253Apmid%252F11157525%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=bmj&resid=322/7281/261&atom=%2Fbmj%2F322%2F7298%2F1367.atom
The Targeted Histone Deacetylase Inhibitor Tefinostat (CHR-2845) Shows Selective In Vitro Efficacy In Monocytoid-Lineage Acute Myeloid Leukaemia (AML)
Authors: Joanna Zabkiewicz, Marie Gilmour, Robert K. Hills, Elizabeth Bone, Alan Davidson, Alan K. Burnett, Steven Knapper
Journal: Blood (2013)
Subclinical Hyperthyroidism
Authors: Anthony D. Toft
Journal: New England Journal of Medicine (2001)

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author's clinical recommendations. A 67-year-old woman presents with palpitations and is found to be in atrial fibrillation at a rate of 120 beats per minute. The only other finding on physical examination is a goiter, which is known to be long-standing. Echocardiography shows neither valvular disease nor left ventricular systolic dysfunction. The serum thyrotropin concentration is less than 0.05 mU per liter, and the serum total triiodothyronine and free thyroxine concentrations are in the normal range. Should the thyroid dysfunction be treated?The Clinical ProblemThe combination of an undetectable serum thyrotropin concentration, as measured by an assay with a threshold of . . .
Directions for New Anti-asthma Drugs
Journal: Thorax (1989)

ness, again when applied to the whole population of asth- matic individuals, leads to a disproportionate increase in the proportion of those with severe disease.The probable validity of the second assumption can be illustrated (figure) by comparing childhood asthma prevalence in England and New Zealand (EA Mitchell, HR Anderson, unpublished study).The lifetime prevalence of wheeze in Auckland, New Zealand, is 18-5% higher than in South West Thames, England (25-6% v 21-6%), the prevalence of wheeze in the last 12 months 32-1% higher (14-8% v 11-2%), and the prevalence of wheeze in the last month 87-5% higher (7 7% v 4-1%).Thus there is a difference in the distribution ofasthma severity between the two countries.Could this be produced by New Zealand's higher asthma drug consumption2 and the promotion of maintenance beta agonists?Dr Gregg speculates that "pan-adrenoceptor" agonists may be superior to selective beta2 agonists in relieving and preventing mucosal oedema.These drugs were effective when used intermittently for acute severe asthma.The hypothesis, however, relates to long term regular use.The recent report suggesting that fenoterol, a less selective beta2 agonist, might increase the risk of death in patients with asthma3 indicates the need for caution before returning to even less selective adrenoceptor agonists.
Perinatal death associated with planned home birth in Australia
Authors: P. Sullivan, S. K. Tracy, H. Bastian, M. J N C Keirse, P. A L Lancaster
Journal: BMJ (1999)

<h3>Background</h3> Nowadays polytherapy is widely used in older patients affected by comorbidity but it implies changing kinetics and dynamics which can increase the probability of negative drug interactions resulting in therapeutic failure and/or adverse drug reactions. <h3>Purpose</h3> The aim of this study was to retrospectively assess the prescriptions of discharged patients to assess potential drug interactions in terms of frequency and characteristics. <h3>Materials and methods</h3> The retrospective study was carried out considering the data within the period from 1 January to 31 March 2011. The study examined prescriptions with at least two drugs for patients older than 65 who were discharged from the General Medicine Unit of Azienda Ospedaliero Universitaria S. Maria della Misericordia in Udine. Drug interactions were identified and assessed using the Micromedex DrugReax System. <h3>Results</h3> The data involved 181 patients (44% male and 56% female): 12% in the range between 65 and 70 years, 79% in the range between 71 and 90 years and 9% of patients older than 90 years. Most patients had between 5 and 10 drugs (69%). The rest of them: 16% of patients had fewer than five drugs, 14% between 11 and 15 drugs and 1% more than 15 drugs. The authors analysed 1348 prescriptions. The therapeutic classes most frequently prescribed were: antithrombotic agent (161 prescriptions, 11.9%), diuretics (129 prescriptions, 9.6%), drugs for acid-related disorders and drugs for the heart (121 prescriptions, 9%). Furosemide (8.0%), pantoprazole (7.0%), acetylsalicylic acid and ramipril (5.3%) were the most frequently prescribed drugs. According to the Micromedex DrugReax database, only the treatments of 34 patients (19%) did not show potential drug interactions. The database responses pointed out 633 potential drug interactions, 47% of total prescriptions: 2% of minor, 78% of moderate and 20% of major severity. This meant that major-severity drug reactions were possible in 74 different prescriptions: ramipril-spironolactone (eight prescriptions) and simvastatin-warfarin (five prescriptions) being the most frequent. <h3>Conclusions</h3> The percentage of major-severity potential drug interactions was low. However, in order to improve the quality of healthcare, the key reading of the results was the opportunity to initiate a control procedure to prevent negative effects from the drug interaction. Clinical pharmacists should have a key role, using their expertise in a proactive exchange with the clinical prescriber when the treatment is decided. This might avoid potentially dangerous drug interactions that might lead to therapeutic failure and/or adverse drug reactions. Possible suggestions might include modification of time scheduling for drug administration. Finally clinical pharmacists should also educate patients to promote compliance with the drug administration regimen.
Abstract 17072: Mitochondrial Import of miRNA as a Mechanism of Mitochondrial Gene Regulation
Authors: Samarjit Das, Marcella Ferlito, Richard Wang, Delong Liu, Nalini Raghavachari, Sarah Wheelan, Elizabeth Murphy, Charles Steenbergen
Journal: Circulation (2011)

Mitochondria are semi-autonomous cellular organelles with their own genome, which not only act as the powerhouse of the cell by supplying energy through oxidative phosphorylation, but also play a destructive role through participation in cell death pathways. MicroRNAs (miRNAs) are usually 19-25 nt long, non-coding RNAs, involved in post-transcriptional gene regulation by binding to the 3'-untranslated regions (3'-UTRs) of target mRNA. Here we report a specific miRNA, miR-181c, in the mitochondrial fraction of rat heart. We find that miR-181c is encoded in the nucleus, assembled in the cytoplasm, and finally translocated into the mitochondria. Bioinformatics studies indicated that cytochrome c oxidase subunit 1 (mt-COX1) in the mitochondrial genome may be a target of miR-181c. To study whether miR-181c could regulate mt-COX1, we over-expressed precursor miR-181c (or scramble sequence) in rat neonatal ventricular cardiomyocytes (NRVM). Over-expression of miR-181c did not change mt-COX1 mRNA but significantly decreased mt-COX1 protein expression, suggesting that miR-181c acts primarily on translational regulation of mt-COX1. In addition to altering COX1, we also found that over-expression of miR-181c resulted in increased mt-COX2 mRNA and protein content. On the functional level, over-expression of miR-181c modulates mitochondrial respiration and ROS generation in NRVM. Thus, our data show for the first time that miR-181c can enter and target the mitochondrial genome, which ultimately causes electron transport chain complex IV remodeling and alters mitochondrial function. This unique observation may open a new dimension to our understanding of mitochondrial dynamics.
A comparative study of Vietnamese Amerasians, their non-Amerasian siblings, and unrelated, like-aged Vietnamese immigrants
Authors: R S McKelvey, J A Webb
Journal: American Journal of Psychiatry (1996)

The authors compared the personal histories, levels of psychological distress, and adaptation to American life of Vietnamese Amerasians (N=140), their non-Amerasian siblings (N=71), and a group of unrelated, like-aged Vietnamese immigrants (N=118).Subjects completed two self-administered symptom checklists and provided demographic and personal history data.Vietnamese Amerasians differed significantly from the other two groups on measures of alcohol use, number of hospitalizations, years of education, childhood trauma, perceived effects of trauma, and score on the Vietnamese Depression Scale. The Amerasians did not, however, differ on measures of social support or in their success at adapting to life in the United States.Despite multiple disadvantages, Vietnamese Amerasians appear to be adapting to life in the United States as well as other like-aged Vietnamese immigrants.
Timing of the Loss of Pten Is Critical in Determining the Disease Phenotype in Mice- a Mouse Model for Pediatric Mixed MDS/MPN
Authors: Y. Lucy Liu, Yan Yan, Cody Webster, Lijian Shao, Shelly Y. Lensing, Hongyu Ni, Wei Feng, Daohong Zhou, Zhifu Xiang, Natalia Colorado, Delli Robinson, Shaoguang Li, Peter D Emanuel
Journal: Blood (2014)
Abstract 17360: Genome-Wide Meta-Analysis of Plasminogen Activator Inhibitor Type 1 (PAI-1) Identifies a New Locus Independent of the Serpine1 4G/5G Polymorphism
Authors: Jie Huang, Maria Sabater-Ileal, Jens Baumert, So-Youn Shin, Qiong Yang, John Ohrvik, Andrew D Johnson, Kurt Lohman, Jingzhong Ding, Rona J Strawbridge, Wolfgang Koenig, Nicole Soranzo, Yongmei Liu, Christopher J O'Donnell, Anders Hamsten
Journal: Circulation (2010)

Introduction: Thrombosis underlies myocardial infarction and other cardiovascular diseases (CVD). Plasminogen activator inhibitor type 1 (PAI-1) is produced by the vascular endothelium and is consi...
Abstract 19836: Lipid Metabolism is Modified by the Interaction Between Cholesteryl Ester Transfer Protein Gene Polymorphism and Mediterranean Diet in Patients in Secondary Prevention for Cardiovascular Disease
Authors: Antonio Garcia Rios, Francisco Gomez-Delgado, Ana Isabel Perez Caballero, Andreea Corina-Baba, Vanesa Navarro-Martos, Carmen Marin-Hinojosa, Jose Lopez-Miranda, Pablo Perez-Martinez
Journal: Circulation (2014)

Introduction: Cholesteryl ester transfer protein (CETP) gene has been implicated in lipid metabolism. However, little is known about the impact of this gene on coronary heart disease (CHD) patients and its interaction with diet. Hypothesis: To evaluate whether the chronic consumption of a Mediterranean diet enriched in olive oil, compared with a Low fat diet, interacts with the rs3764261 SNP at CETP locus in order to modify lipid metabolism among MetS patients from the CORDIOPREV clinical trial Methods: Plasma lipid concentrations and rs3764261 genotypes were determined in 424 MetS subjects participating in the CORDIOPREV clinical trial. Gene-diet interactions were analyzed after a year of dietary intervention (Mediterranean diet (35% fat, 22% MUFA) vs Low fat diet (28% fat, 12% MUFA)) Results: We found significant gene-diet interactions between rs3764261 SNP and the dietary pattern for HDL-C ( P=0.006 ) and triglyceride concentrations ( P=0.040 ). Specifically, after 12 months of Mediterranean diet intervention, subjects who were carriers of the minor T allele (TT+TG) displayed higher plasma HDL-C concentrations ( P=0.021 ) and lower triglycerides ( P=0.020 ) compared with homozygous for the major allele (GG). In contrast, in the Low fat intervention group no significant differences were found between CETP genotypes after 12 months of dietary treatment. Conclusions: Our data support the notion that a chronic consumption of a Mediterranean diet may play a contributing role in triggering lipid metabolism by interacting with the rs3764261 SNP at CETP gene locus in MetS patients