tbuckley/cabot-search huggingface dataset:
Sarcolemmal sodium permeability and contractile force of guinea pig papillary muscle: effects of germitrine.
Authors: PHonerjäger, MReiter
Journal: Circulation Research (1977)

The action potential of guinea pig papillary muscle exposed to the ceveratrum alkaloid germitrine (2 mugM) is followed by a long-lasting after-depolarization (maximal amplitude, 8 mV; half-time of decay, 32 seconds; total duration, approximately 75 seconds). This after-depolarization interrupts the terminal phase of repolarization. During repetitive stimulation (0.1-1.0 Hz; 80 nM germitrine) the after-depolarizations that follow consecutive action potentials are summed, causing persistent depolarization of up to 10 mV. The after-depolarization is reversibly abolished by tetrodotoxin (TTX). Test contractions evoked at various times during or after the germitrine-induced after-depolarization reveal a phase during which the ability of the muscle to develop force is transiently increased. This positive inotropic influence reaches its maximum 1 minute after the conditioning stimulus and thereafter decays with a half-time 4.8 times longer than the half-time of decay of the after depolarization. It is reversibly...
Mediastinoscopy after negative endoscopic mediastinal nodal staging: can it be omitted?
Authors: Jouke T. Annema, Paul De Leyn, Paul Clementsen, Mette Siemsen, Peter Vilmann
Journal: European Respiratory Journal (2015)

We read with interest the comments of Li and colleagues on the need for a routine mediastinoscopy following a nodal negative endosonographic mediastinal evaluation. This topic is frequently a subject of discussion in multidisciplinary lung cancer teams and therefore deserves full attention. NSCLC staging: mediastinoscopy can be omitted in selected cases following a nodal negative EBUS/EUS examination <http://ow.ly/TKKkf>
ESR1 gene amplification in breast cancer: a common phenomenon?
Authors: Jorge S Reis-Filho, Suzanne Drury, Maryou B Lambros, Caterina Marchio, Nichola Johnson, Rachael Natrajan, Janine Salter, Pauline Levey, Olivia Fletcher, Julian Peto, Alan Ashworth, Mitch Dowsett
Journal: Nature Genetics (2008)
Further evidence implicating a cytochrome P-450-mediated reaction in the contractile tension of the lamb ductus arteriosus.
Authors: FCoceani, C ABreen, J GLees, J RFalck, P MOlley
Journal: Circulation Research (1988)

The authors have recently provided evidence implicating the cytochrome P-450 system in the generation of contractile tension of the ductus arteriosus. To confirm this possibility, carbon monoxide (CO/O2 ratio, 0.27) and cytochrome P-450 inhibitors [4-phenylimidazole; 14-isocyano,15-(methoxymethyleneoxy)-5Z,8Z,11 Z-eicosatrienoic acid; 9-hydroxyellipticine; alpha-naphthoflavone] were tested on the isolated ductus arteriosus from mature fetal lambs equilibrated at low (4-26 mm Hg) or high (229-694 mm Hg) O2 partial pressure (PO2). Carbon monoxide completely relaxed intact vessel wall preparations and preparations consisting of only the muscle. Carbon monoxide relaxation was reversed by illumination with monochromatic light and the peak for the photoactivated contraction occurred at 450 nm. 4-Phenylimidazole (100 and 1,000 microM) was also a relaxant agent, and its action was manifest at both low and high PO2. Unlike 4-phenylimidazole, the isonitrile compound (5 microM) and 9-hydroxyellipticine (10 and 100 m...
Minoxidil in patients with chronic left heart failure: contrasting hemodynamic and clinical effects in a controlled trial.
Authors: J AFranciosa, R AJordan, M MWilen, C LLeddy
Journal: Circulation (1984)

Minoxidil, a potent predominant arterial dilator, improves hemodynamics over the short term in patients with heart failure. In random double-blind fashion 17 patients with chronic left heart failure were given minoxidil (nine patients) or placebo (eight patients) in addition to digoxin and diuretics for 3 months. Cardiac index and heart rate increased and mean arterial pressure and systemic vascular resistance fell within 4 hr of minoxidil administration. Right heart and pulmonary arterial pressures were unchanged over the short term but rose after long-term minoxidil. After 3 months of minoxidil treatment, systemic vascular resistance was still reduced (11.7 +/- 6.3[SD] vs 17.1 +/- 3.1 U at baseline; p less than .05). Hemodynamics were similar at baseline and remained unchanged during placebo treatment. Mean left ventricular ejection fraction rose from 29.6 +/- 17.7% to 42.7 +/- 22.3% (p less than .05) after 3 months of minoxidil treatment (this result was influenced largely by responses in two patients)...
Contribution of Colonoscopy in Patients With Melena and Normal Upper Gastro-Intestinal Endoscopy
Authors: R Harbi, S Mrabet, S Zaouga, I Akkari, Jazia E Ben
Journal: Endoscopy (2021)

Aims A melena is the release through the anus of black, fetid digested blood, the origin of the bleeding is located upstream of the right colon
Autoantibody-mediated impairment of DNASE1L3 activity in sporadic systemic lupus erythematosus
Authors: Johannes Hartl, Lee Serpas, Yueyang Wang, Ali Rashidfarrokhi, Oriana A. Perez, Benjamin Sally, Vanja Sisirak, Chetna Soni, Alireza Khodadadi-Jamayran, Aristotelis Tsirigos, Ivan Caiello, Claudia Bracaglia, Stefano Volpi, Gian Marco Ghiggeri, Asiya Seema Chida, Ignacio Sanz, Mimi Y. Kim, H. Michael Belmont, Gregg J. Silverman, Robert M. Clancy, Peter M. Izmirly, Jill P. Buyon, Boris Reizis
Journal: The Journal of Experimental Medicine (2021)

Antibodies to double-stranded DNA (dsDNA) are prevalent in systemic lupus erythematosus (SLE), particularly in patients with lupus nephritis, yet the nature and regulation of antigenic cell-free DNA (cfDNA) are poorly understood. Null mutations in the secreted DNase DNASE1L3 cause human monogenic SLE with anti-dsDNA autoreactivity. We report that &amp;gt;50% of sporadic SLE patients with nephritis manifested reduced DNASE1L3 activity in circulation, which was associated with neutralizing autoantibodies to DNASE1L3. These patients had normal total plasma cfDNA levels but showed accumulation of cfDNA in circulating microparticles. Microparticle-associated cfDNA contained a higher fraction of longer polynucleosomal cfDNA fragments, which bound autoantibodies with higher affinity than mononucleosomal fragments. Autoantibodies to DNASE1L3-sensitive antigens on microparticles were prevalent in SLE nephritis patients and correlated with the accumulation of cfDNA in microparticles and with disease severity. DNASE1L3-sensitive antigens included DNA-associated proteins such as HMGB1. Our results reveal autoantibody-mediated impairment of DNASE1L3 activity as a common nongenetic mechanism facilitating anti-dsDNA autoreactivity in patients with severe sporadic SLE.
Cardiovascular involvement in osteogenesis imperfecta.
Authors: JHortop, PTsipouras, J AHanley, B JMaron, J RShapiro
Journal: Circulation (1986)

While aortic root dilatation and valvular dysfunction have been well-documented in osteogenesis imperfecta (OI), the nature and extent of cardiovascular involvement in OI have not been clearly delineated. A clinical and echocardiographic survey involving 109 individuals with various nonlethal OI syndromes from 66 separate families was undertaken. Clinically discernible valvular dysfunction was encountered in only four of the 109 individuals (aortic regurgitation in two, aortic stenosis in one, and mitral valve prolapse in one), none of whom were related. Aortic root dilatation was recognized echocardiographically in eight (12.1%) of 66 individuals comprising a subset of the sample in which each family was represented by a single individual. The extent of the aortic root dilatation was mild (the largest dimension measuring 4.3 cm) and was unrelated to the age of the individual. Dilatation was seen in each of the different OI syndromes but was strikingly segregated within certain families (p less than .001)...
The significance of the late fall in myocardial PCO2 and its relationship to myocardial pH after regional coronary occlusion in the dog.
Authors: S FKhuri, R AKloner, S AKaraffa, WMarston, A DTaylor, N CLai, D ETow, E MBarsamian
Journal: Circulation Research (1985)

After acute regional coronary occlusion, myocardial tissue PCO2, as measured by mass spectrometry, rises, reaches a peak, and then gradually falls. This late fall in myocardial tissue PCO2 could be due to (1) a gradual increase in tissue blood flow (and hence improved carbon dioxide washout), (2) a gradual consumption of tissue bicarbonate, (3) a gradual reduction in the production of carbon dioxide due to progressive cellular damage, or (4) an artifact caused by the continued presence of the mass spectrometer probe in the ischemic tissue. To determine which of these four mechanisms is responsible for the late fall in myocardial tissue PCO2, we subjected 27 anesthetized open-chest dogs to 3-hour occlusion of the left anterior descending coronary artery. Both myocardial tissue PCO2 and intramyocardial hydrogen ion concentration were measured in the myocardial segment supplied by the left anterior descending coronary artery. Ten dogs (group 1) were killed after the occlusion (occlusion I), and 11 dogs (grou...
Macroscopic on-Site Evaluation (MOSE) of Acquired Specimens Of Solid Lesions During EUS-FNB: A Multicenter Study and a Comparison Between Needles Gauge
Authors: B Mangiavillano, L Frazzoni, T Togliani, C Fabbri, I Tarantino, L De Luca, T Staiano, C Binda, M Signoretti, LH Eusebi, L Lamonaca, F Auriemma, D Paduano, M Di Leo, M Bianchetti, S Carrara, L Fuccio, A Repici
Journal: Endoscopy (2021)

Aims The standard methods to obtain sampling during endoscopic ultrasonography (EUS) is the fine needle aspiration (FNA) which could be affected by the presence of cytopathologist in endoscopy room (ROSE). With the introduction of fine needle biopsy (FNB), the macroscopic on-site evaluation (MOSE) of the acquired specimen was proposed. Few studies are published about this issue and in all, except one, a 19G needle was used, influencing the accuracy. The primary aim of our study was to evaluate the yield and accuracy of MOSE with different needles’ gauge and the secondary aim was to identify factors influencing the yield of MOSE.
Cowden Syndrome: Case Report
Authors: G Sofianidis, I Moschos, G Tikos, A Paikos, K Evagelopoulos, D Paikos
Journal: Endoscopy (2021)

Aims Cowden syndrome (CS) is a rare disease, inherited in an autosomal dominant pattern with an estimated incidence 1 in 200,000 to 250,000 people. It is associated with germline mutations in the phosphatase and tensin homologue (PTEN) gene. The pathognomonic features of CS are mucocutaneous lesions (trichilemmomas, acral ceratoses and pappilomatous lesions). Patients with CS have a high lifetime risk of breast, thyroid, uterine, and other cancers. Gastrointestinal polyposis is a common manifestation and can occur throughout the entire tract.
Polycythaemia vera and central sleep apnoea.
Authors: J R Stradling, D J Lane
Journal: BMJ (1980)

lationship of solution pH to biological activity.All the available data indicate that alkaline glutaraldehydes, including Cidex Long-Life, are significantly more active against microorganisms than acid glutaraldehydes, in- cluding Sonacide.'-4These data, coupled with the fact that Cidex Long-Life is only slightly less chemically stable than Sonacide, enable us to state categorically that Sonacide does not have a longer use life than Cidex Long- Life when compared under identical conditions of use.In addition, Cidex Long-Life has greatly superior anti-corrosion properties throughout an equivalent use period.
The dexamethasone suppression test in adolescent psychiatric patients
Authors: H Ha, S Kaplan, C Foley
Journal: American Journal of Psychiatry (1984)

The authors administered a structured psychiatric interview, the Kiddie-SADS, and the dexamethasone suppression test (DST) to 42 adolescent psychiatric inpatients. Of the 26 adolescents diagnosed as depressed, nine (36.4%) failed to suppress cortisol, and of the 16 nondepressed adolescents, three (18.8%) also failed to suppress cortisol. There was no significant association between the diagnosis of depression and the failure to suppress cortisol during the DST. The use of the DST to diagnose endogenous major depressive illness in adolescents seems to be a premature clinical application of an important investigative finding.
Systemic oxygen transport in patients with congenital heart disease.
Authors: WBerman, S CWood, S MYabek, TDillon, R RFripp, RBurstein
Journal: Circulation (1987)

The physiology of oxygen delivery was studied in 118 stable patients from 3 months to 20 years old with congenital heart disease. During cardiac catheterization, oxygen consumption (VO2), arterial and venous blood gases and oxygen saturations (range 41% to 98%), hemoglobin concentration, diphosphoglycerate (2,3-DPG), and P50 levels were measured, and then cardiac output, systemic oxygen transport (SOT), arterial and venous oxygen contents, and the VO2/SOT ratio (fractional O2 extraction) were calculated. P50 averaged 31 mm Hg, compared with 27 mm Hg in 10 control children (p less than .01). The composite O2-hemoglobin dissociation curve in vivo was broad: Po2 varied from 37 to 65 mm Hg at 80% saturation. P50, 2,3-DPG, hemoglobin concentrations, and O2 saturation varied widely and inconsistently with Po2 and arterial and venous O2 content, but resulted in clustering of the arterial oxygen content near 165 +/- 23 (SD) ml/liter over a wide range of Po2 and hemoglobin concentrations. SOT varied in direct rela...
The transition to ventricular fibrillation induced by reperfusion after acute ischemia in the dog: a period of organized epicardial activation.
Authors: R EIdeker, G JKlein, LHarrison, W MSmith, JKasell, K AReimer, A GWallace, J JGallagher
Journal: Circulation (1981)

Ventricular fibrillation was induced in eight of 10 open-chest dogs by reperfusion after a 15-minute occlusion of the proximal circumflex coronary artery. Simultaneous recordings were made from 27 epicardial electrodes spaced over both ventricles. Analysis of the initial 1.5--2.5 seconds of the transition from sinus rhythm or ventricular tachycardia to fibrillation revealed that ventricular activation occurred in an orderly, rapidly repeating sequence in all hearts. Each activation from arose near the border of the ischemic-reperfused region and passed across the nonischemic portion of the ventricles to the opposite side of the heart as a single, organized wavefront. As the arrhythmia progressed, the time between the appearance of successive activation fronts on the epicardium decreased. Concurrently, the time for each activation front to traverse the ventricles increased. The stimulation increase in rate of appearance and decrease in conduction velocity for each successive cycle resulted in overlapping c...
Increased intrinsic pumping of intestinal lymphatics following hemorrhage in anesthetized sheep.
Authors: AHayashi, M GJohnston, WNelson, SHamilton, N GMcHale
Journal: Circulation Research (1987)

The return of fluid and protein to the bloodstream by the lymphatic circulation may play an important role in reconstituting intravascular volume following hemorrhage. In this study, we have defined the lymph-flow changes that occur in cannulated mesenteric lymphatics following a 25% blood loss in anesthetized sheep and investigated the effects of hemorrhage on the intrinsic contractile activity (lymph pumping) of these vessels in vivo using a new model system. The removal of 25% of the calculated blood volume resulted in increases in lymph flow over a 6-hour period, with peak changes to 3.5 times the prebleed levels. Systemic arterial pressures dropped to roughly 50% of control values immediately following the bleed and returned to control in 3 hours. To directly assess the effects of hemorrhage on lymphatic pumping, a segment of intestinal lymphatic was isolated from all lymph input and supplied with fluid from a reservoir. While there was no net pressure driving fluid through the duct, a transmural dis...
Reevaluation of Amiodarone
Authors: Saeed Ahmad
Journal: Annals of Internal Medicine (1995)

Letters15 November 1995Reevaluation of AmiodaroneSaeed Ahmad, MDSaeed Ahmad, MDCardio-Diagnostic Clinique; Fairmont, WV 26554Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-10-199511150-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with interest the recent article by Podrid [1]. Some important issues arising from this review warrant discussion. First, the mechanism of the observed toxicity may result from the accumulation of substances such as iodine or amiodarone, given that 37.5% of the weight of the drug is iodine. It has been postulated that because both amiodarone and angiographic dyes contain iodine, the combination may cause an additive toxic effect and subsequent death after pulmonary angiography [2]. In addition, Sadek and colleagues [3] recently described amiodarone-induced epididymitis and reviewed 12 additional cases in the literature.Reports of ...References1. Podrid PJ. Amiodarone: reevaluation of an old drug. Ann Intern Med. 1995; 122:689-700. Google Scholar2. Malden E, Gutierrez F. Acute fatality following pulmonary angiography in a patient on an amiodarone regimen—a case report. Angiology. 1993; 44:152-5. Google Scholar3. Sadek I, Biron P, Kus T. Amiodarone-induced epididymitis: report of a new case and literature review of 12 cases. Can J Cardiol. 1993; 9:833-6. Google Scholar4. Dobs A, Sarma P, Guarnieri T, Griffith L. Testicular dysfunction with amiodarone use. J Am Coll Cardiol. 1991; 18:1328-32. Google Scholar5. Gore J, Haffajee C, Alpert J. Interaction of amiodarone and diphenyl-hydantoin. Am J Cardiol. 1984; 54:1145-56. Google Scholar Author, Article, and Disclosure InformationAuthors: Saeed Ahmad, MDAffiliations: Cardio-Diagnostic Clinique; Fairmont, WV 26554 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 November 1995Volume 123, Issue 10Page: 809KeywordsAnestheticsAttentionDrug interactionsFollicle-stimulating hormoneLuteinizing hormoneTestesTestosteroneThyroidThyroid diseasesToxicity ePublished: 15 August 2000 Issue Published: 15 November 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Evaluating the potential cost-effectiveness of stenting as a treatment for symptomatic single-vessel coronary disease. Use of a decision-analytic model.
Authors: D JCohen, J ABreall, K KHo, R EKuntz, LGoldman, D SBaim, M CWeinstein
Journal: Circulation (1994)

BACKGROUNDCoronary stenting appears to provide more predictable immediate results and lower rates of restenosis than conventional balloon angioplasty for selected lesion types, but its hospital costs are significantly higher. This study was designed to evaluate the potential cost-effectiveness of Palmaz-Schatz coronary stenting relative to conventional balloon angioplasty for the treatment of patients with symptomatic, single-vessel coronary disease.METHODS AND RESULTSWe developed a decision-analytic model to predict quality-adjusted life expectancy and lifetime treatment costs for patients with symptomatic, single-vessel coronary disease treated by either Palmaz-Schatz stenting (PSS) or conventional angioplasty (PTCA). Estimates of the probabilities of overall procedural success (PTCA, 97%; PSS, 98%), abrupt closure requiring emergency bypass surgery (PTCA, 1.0%; PSS, 0.6%), and angiographic restenosis (PTCA, 37%; PSS, 20%) were derived from review of the literature published as of September 1993. Proced...
Cholesterol increases the L-type voltage-sensitive calcium channel current in arterial smooth muscle cells.
Authors: LSen, R ABialecki, ESmith, T WSmith, W SColucci
Journal: Circulation Research (1992)

To determine whether membrane free cholesterol affects calcium currents in vascular smooth muscle cells, whole-cell patch clamp recordings were made before and after cholesterol enrichment of cells by exposure to cholesterol-rich liposomes. Exposure to cholesterol-rich liposomes resulted in a gradual increase in the L-type current over 20 hours and a plateau (73 +/- 7% increase over basal) between 20 and 32 hours. This effect was associated with a rightward shift in the inactivation potential and a decrease in the sensitivity to (-)-PN-202-791, a dihydropyridine antagonist. There was no change in the maximum L-type current stimulated by (+)-PN-202-791, a dihydropyridine agonist. Liposome exposure caused a small, transient increase in the T-type current (peak effect, 20 minutes). We conclude that membrane cholesterol has important effects on the L-type calcium current in vascular smooth muscle cells, which is most likely due to an alteration in channel functional state rather than an increase in channel ex...
The direct electrophysiologic effects of disopyramide phosphate in the transplanted human heart.
Authors: R SBexton, K JHellestrand, RCory-Pearce, R ASpurrell, T AEnglish, A JCamm
Journal: Circulation (1983)

To evaluate the direct electrophysiologic effects of i.v. disopyramide phosphate and to differentiate these effects from its autonomically mediated actions, we administered the drug (2 mg/kg over 5 minutes) during electrophysiologic study to eight cardiac transplant recipients who had documented functional cardiac denervation. After disopyramide, the cycle length of the denervated donor right atrium increased from 626 +/- 129 to 716 +/- 148 msec (mean +/- SD, p less than 0.001), whereas that of the innervated recipient atrium decreased from 846 +/- 195 to 659 +/- 99 msec (p less than 0.02). There were small increases in both the sinus node recovery time (1128 +/- 616 to 1198 +/- 592 msec, p less than 0.05) and corrected sinus node recovery time (440 +/- 418 to 489 +/- 409 msec, p less than 0.02) of the donor atrium, whereas the recovery times of the recipient atrium shortened (sinus node recovery time, 1298 +/- 218 to 1218 +/- 196 msec; corrected sinus node recovery time, 464 +/- 108 to 410 +/- 115 msec)....
Early detection of abnormal coronary flow reserve in asymptomatic men at high risk for coronary artery disease using positron emission tomography.
Authors: FDayanikli, DGrambow, OMuzik, LMosca, MRubenfire, MSchwaiger
Journal: Circulation (1994)

BACKGROUNDThe objective of this study was to compare coronary flow reserve (CFR) as a measure of vascular integrity in asymptomatic middle-aged men with family history of coronary artery disease (CAD) and a high-risk lipid profile with men without risk factors for CAD using positron emission tomography (PET). Previous studies suggested that the assessment of CFR is a sensitive means to detect vascular abnormalities before angiographic appearance of CAD. N-13 ammonia PET scanning allows noninvasive evaluation of regional and global myocardial blood flow and thereby quantification of CFR.METHODS AND RESULTSWe used dynamic N-13 ammonia PET imaging in conjunction with intravenous adenosine to assess regional and global CFR in asymptomatic middle-aged men with high risk (group 1, n = 16) and men without any known risk factors (group 2, n = 11) for CAD. Group 1 patients were selected based on positive family history of CAD, one or more lipid abnormalities, and a normal stress test. No patient had history of dia...