tbuckley/cabot-search huggingface dataset:
Mental Retardation
Authors: J. Gibson
Journal: BMJ (1963)

the hope of severing a partly cut off tissue or by cutting the tube and allowing the trapped specimen to slough off so that eventually the capsule may be recovered in the faeces.With the tubes designed by Brandborg et al. and our- selves the knife movements are controlled at all times by the pull-wire, and thus any nipped mucosa can be released without trouble.To summarize, we believe that a smaller biopsy aperture, carefully con- trolled use of negative pressure, and indirect control of the movements of the knife make for safe biopsies.With our own child's-size biopsy tube no complications were encountered in 104 successful child biopsies.The investigator has therefore to choose between safety on the one hand, and simplicity of method and perhaps technical superiority on the other hand.Small intestinal biopsy in children must be regarded as a specialized procedure and requires skill and knowledge of tech- nique, whatever method is used.We believe that the pull-wire tubes should not be discarded in favour of the Crosby- Kugler tube, especially in paediatric work.They could certainly be improved technically.Would any paediatrician be interested in trying ?-I am, etc.,
Lectures on the Surgery of Childhood
Authors: A. A. Johnson
Journal: BMJ (1860)

Traumaticseparation of Epiphyses.GsETLENnN,-Towards the close of the lat lecture, I drew your attention to certain congenital hernial protrusions from the skull, constituting encephalocele.In the back we find similar tumours connected with arrest of development in some portion of the spinal oolumn, and formed by the protrusion, .thronghan opening in the canal, of the membranes of the cord, distended with cerebro-spinal fluid.To these the name of spina b(ftda is given, and they are usually characterised by the hard and tense nature of the swelling when the patient is erect, its softness when the pelvis is raised above the headl; expiration and inspirtion producing frequently the same effect.As in the skull, however, the hernia is seldom that of the membranes alone; in the majority of cases, either the spinal cord itself or some of its nerves are more or less involved.
Abstract 24: Sex Differences in Outcomes After Out-of-Hospital Cardiac Arrest Patients: Insights From the Resuscitation Outcomes Consortium Continuous Chest Compression Trial
Authors: Purav Mody, Ambarish Pandey, Rohan Khera, Colby Ayers, Mark Link, Ahamed Idris
Journal: Circulation (2018)

Background: Previous studies examining sex-based differences among out-of-hospital cardiac arrest (OHCA) patients have been conflicting. Methods: Patients with OHCA enrolled in the Continuous Chest Compression trial between 2011 and 2016 were included in the present analysis. Hierarchical multivariable logistic regression models were constructed to evaluate the association between sex and sustained ROSC i.e. ROSC on ER arrival, discharge survival and survival with favorable neurological function after adjustment for age, witnessed status, presenting rhythm, public location, bystander CPR, resuscitation duration, and EMS response time. Results: Among 22,540 OHCA patients, 8,099 (35.9%) were women. Women were older (median 71 vs. 67 years), received less bystander CPR (45% vs. 47%), and had a lower proportion of cardiac arrests that were witnessed (39% vs. 45%) or had an initial shockable rhythm (15% vs. 28%, p&lt;= 0.001 for all). There was no difference in sustained ROSC rates (24.7% vs. 24.8%, p=0.7) but discharge survival (6.5% vs. 10.3%, p&lt;0.001) and survival with favorable neurological function (4.9 vs. 8.6%, p&lt;0.001) were significantly lower in women (vs. men). In adjusted analysis, women (vs. men) had significantly higher likelihood of sustained ROSC ( Table ) but no difference in likelihood of discharge survival and survival with favorable neurological function. In the adjusted landmark analysis beginning after achieving ROSC, women had significantly lower likelihood of discharge survival and survival with favorable neurological function ( Table ) . Conclusions: Among resuscitated OHCA patients, women have a higher likelihood of achieving sustained ROSC despite a higher burden of poor prognostic factors. However, after successful ROSC, the likelihood of discharge survival is significantly lower in women (vs. men). Future studies are needed to understand how care provided post-ROSC may modify the sex-disparities in discharge survival outcomes.
Post hoc analysis of the efficacy of pembrolizumab retreatment after progression of advanced urothelial carcinoma (UC) in KEYNOTE-045 and KEYNOTE-052.
Authors: Daniel E. Castellano, Arjun Vasant Balar, Peter H. O'Donnell, Petros Grivas, David J. Vaughn, Thomas Powles, Jacqueline Vuky, Jae-Lyun Lee, Yves Fradet, Joaquim Bellmunt, Miguel Ángel Climent, Nicholas J. Vogelzang, Elizabeth R. Plimack, Howard Gurney, Noah M. Hahn, Cora N. Sternberg, Jin Zhi Xu, Kentaro Imai, Blanca Homet Moreno, Ronald De Wit
Journal: Journal of Clinical Oncology (2022)

512 Background: Pembrolizumab (pembro) has shown efficacy in advanced/unresectable and metastatic UC (mUC). There is interest in determining whether pts should be treated subsequently with checkpoint inhibitors such as anti–PD-1 therapy if mUC responds then later progresses. Pembro retreatment after disease progression has shown efficacy in melanoma and NSCLC. This post hoc exploratory analysis investigated the efficacy of pembro retreatment for pts with advanced UC or mUC enrolled in KEYNOTE-045 and KEYNOTE-052 with a best overall response (BOR) of SD or better and whose disease progressed after discontinuation or completion of 2 y of therapy. Methods: The phase 3 KEYNOTE-045 trial (NCT02256436) was designed to compare the efficacy and safety of pembro vs chemotherapy (chemo) in pts with mUC that recurred/progressed on platinum containing chemo; ≤2 prior lines of systemic chemo for mUC were permitted. The phase 2 KEYNOTE-052 trial (NCT02335424) was designed to evaluate the efficacy and safety of first-line pembro in cisplatin-ineligible pts with advanced UC. In both studies, pembro was administered for up to 2 y; pts were eligible for retreatment if they stopped pembro after CR or had a BOR of CR, PR, or SD and completed 2 y of treatment. Pts must have investigator-confirmed radiographic PD after therapy cessation, have ECOG PS score 0-1, and not have received anticancer treatment after the last pembro dose. BOR to retreatment is reported. Results: At data cutoff for KEYNOTE-045 (Oct 1, 2020), 11 pts were retreated: 5 (45%) achieved objective response to retreatment (3 CR; 2 PR; Table) and 6 had SD, for a disease control rate (DCR; CR+PR+SD) of 100%. Median treatment-free interval was 7.7 mo (IQR, 3.6-16.5); median duration of retreatment was 11.4 mo (IQR, 7.6-12.0). Seven pts (64%) were alive at cutoff. At data cutoff for KEYNOTE-052 (Sep 26, 2020), 10 pts were retreated; 5 (50%) had objective response to retreatment (1 CR; 4 PR) and 4 had SD, for a DCR of 90%. Retreatment BOR was PD for 1 pt (10%). Median treatment-free interval was 13.0 mo (9.2-16.6); median duration of retreatment was 6.0 mo (IQR, 4.9-9.2). Four pts (40%) were alive at cutoff. Conclusions: Although the number of pts who received retreatment was small, objective responses were observed. The findings are generally consistent with observations from retreatment in other tumor types (e.g., melanoma). Clinical trial information: NCT02256436 and NCT02335424. [Table: see text]
Weaning.
Authors: H B Valman
Journal: BMJ (1980)

Weaning is the process of getting the baby used to eating foods other than milk and using a spoon and cup.For the first four months of life the baby will need only milk and additional drinks of boiled water.New foods should start to be introduced at about 4 to 6 months.If solid foods are introduced too early the baby may become too fat; if they are introduced too late there may be problems with chewing.Once introduced, solid foods should be given regularly and in gradually increasing quantities.As the amount of solid food increases the number or size of milk feeds should decrease.Mothers need a small wide plastic teaspoon with no sharp edges, a small plastic cup or bowl, a feeding beaker, and a cotton or pelican-type bib.The feeding equipment should be kept in a sterilising solution.If a metal spoon is used it should be scalded in boiling water and then allowed to cool before being used.Firstly, the baby has to be taught to take food from the spoon rather than just sucking.He should also be given plenty to drink to replace the milk: at least 100 to 150 ml of water or diluted fruit juice each day.Most fruit squashes are unsuitable for babies.a--8om Milk 10 am Milk B-by.cereal
Memory loss.
Authors: R A Wood
Journal: BMJ (1984)

Memory loss covers a wide range of medicine, neurology, and psychiatry.This account touches on various conditions in which memory loss is only part of the picture, but I have emphasised pure amnesic states or others in which amnesic symptoms can occur early in the course of the illness.The importance lies in the early recog- nition of the treatable and in preventing deterioration where the cause is not inexorably progressive.The main subdivision is between amnesia of sudden onset, in which the outcome is usually favourable, and slow onset amnesia-often with global dementia-where it is not. MemoryDefects of memory are either in the registration of new experience (antegrade) or the recall of past experience (retrograde).In gross dementia the patient may lose the ability to repeat a series of numbers he has just heard.This immediate type of defect is also seen in dysphasia, or whenever attention or concentration is dis- tracted-as in depression or acute confusional states.Short term memory deficit is tested by inviting the recall of a few numbers and two or three names after five minutes of other conversation.The limbic system, including the mamillary bodies and hippocampus, must be intact for new experience to be registered and recent events recollected.In Korsakow's amnesia, where the main damage is in the mamillary bodies, antegrade amnesia-learning ability-is permanently damaged and several years ofexperience are lost.After head injury an antegrade defect is noted but this is temporary.The retrograde amnesia shrinks until minutes or seconds before the accident.Deep memory, including childhood events, can be retained and recalled when limbic structures no longer function.The long term memory is tested by asking for details of the patient and his family and about important people or events.Moments of great personal pleasure or poignancy can be recalled most clearly.
Call for Abstracts
Journal: Neuro-Oncology (2003)

Expect the most comprehensive review of cutting-edge laboratory and clinical research in the field of neurooncology at the Eighth Annual Meeting of the Society for Neuro-Oncology (SNO), November 13-16, at Keystone Resort & Conference Center in Colorado.Keystone is the premiere meeting destination in the Colorado Rocky Mountains, AAA-rated Four Diamond, and easily accessible as the winter resort nearest to Denver.The finest of meeting facilities combine with 2000 acres of mountain terrain, skiing, snowboarding, and other winter recreation to offer SNO an exceptional site for an exceptional meeting.Room rates are $124-$140 and include two Mountain Passports for free recreational activities.Kids 12 and under ski and ride free.Keystone Resort & Conference Center also offers full destination services.Group transportation packages, including airfare and ground transportation, have been negotiated with several major air carriers and can be reserved along with lodging by calling the Keystone Conference Reservations Department (800-258-0437), by
Acute abdomen.
Authors: P. Hemphill
Journal: BMJ (1968)

BRITIsHrehabilitation situation that the more severely incapacitated are treated alongside the less handicapped, as this not only constitutes a stimulus to the patients but also to the staff engaged in this work.This review of the present situation is un- doubtedly timely, and one must hope sincerely that the obvious points emerging from it will neither be ignored nor be given the implica- tion that a rash of rehabilitation centres is required.Such rapid expansion is neither economically possible nor entirely desirable.The growth of rehabilitation requires to be carefully planned not only on a regional basis but as part of a carefully designed national policy.
Epidemiology of haemodialysis outcomes
Authors: Aminu K. Bello, Ikechi G. Okpechi, Mohamed A. Osman, Yeoungjee Cho, Htay Htay, Vivekanand Jha, Marina Wainstein, David W. Johnson
Journal: Nature Reviews Nephrology (2022)

Haemodialysis (HD) is the commonest form of kidney replacement therapy in the world, accounting for approximately 69% of all kidney replacement therapy and 89% of all dialysis. Over the last six decades since the inception of HD, dialysis technology and patient access to the therapy have advanced considerably, particularly in high-income countries. However, HD availability, accessibility, cost and outcomes vary widely across the world and, overall, the rates of impaired quality of life, morbidity and mortality are high. Cardiovascular disease affects more than two-thirds of people receiving HD, is the major cause of morbidity and accounts for almost 50% of mortality. In addition, patients on HD have high symptom loads and are often under considerable financial strain. Despite the many advances in HD technology and delivery systems that have been achieved since the treatment was first developed, poor outcomes among patients receiving HD remain a major public health concern. Understanding the epidemiology of HD outcomes, why they might vary across different populations and how they might be improved is therefore crucial, although this goal is hampered by the considerable heterogeneity in the monitoring and reporting of these outcomes across settings. This Review examines the epidemiology of haemodialysis outcomes — clinical, patient-reported and surrogate outcomes — across world regions and populations, including vulnerable individuals. The authors also discuss the current status of monitoring and reporting of haemodialysis outcomes and potential strategies for improvement.
Small-Pox
Authors: R. Bell
Journal: BMJ (1876)

been described with the greatest care, and they would seem identical in kind with those mentioned by Professor Trousseau as characteristic of progressive locomotor ataxy (Trousseau's Clinical Medicine, New Sydenham Society's Translation, vol.i, p. I69), with this distinction, that in the latter they are confined to certain portions of the posterior columns of the spinal cord, whereas in insular sclerosis they occur also in the white matter of the brain.The same intimate pathological changes have also been described under the name of miliary sclerosis in chronic mania, tetanus, leukoemia, and idiocy.(See St. Bartholo- mew's Hospital Reports, vol.viii, on the Morbid Histology of the Spinal Cord, by W. B. Kesteven.)It would seem, therefore, that the disease we have been considering is at present to be distinguished more clearly by its symptoms than by any very special pathology; and perhaps, such terms as rhythmic or oscillating ataxy may hereafter prove to be more applicable than a designation derived from morbid changes, which may not prove to be distinctive.Again, attempts have been made to explain the symptoms by the
Pulsatile Superficial Temporal Artery
Authors: Karl A. Kasischke, David Z. Rose
Journal: JAMA Neurology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Psychotropic drugs.
Authors: R. Rouse
Journal: BMJ (1968)

It is plain that it is difficult to accept the deductions leading to the range of figures quoted as renal thresholds for glucose.Many of the points made in this paper are of the greatest importance in the detection and management of diabetes, and there is no wish to detract from these, but I do not think the renal threshold figures given are necessarily valid.-Iam, etc.,
Morning Groove
Authors: Sylvia S. Villarreal
Journal: Annals of Internal Medicine (2022)

Ad LibitumFebruary 2022Morning GrooveSylvia S. Villarreal, MEd, MPHSylvia S. Villarreal, MEd, MPHMcGovern Center for Humanities and Ethics Houston, TexasSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M21-1621 Audio Reading - “Morning Groove” Audio. Virginia L. Hood, MD, a physician from the University of Vermont, reads “Morning Groove” by Sylvia S. Villarreal, MEd, MPH Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Mornings are soft now, the staccato of waking,feeding, and ferrying children long past. Our rhythmsare solo: You early and occupied, holding shower meetingsthat erupt into spoken words, ghost colleagues bathedin your stream of energy. I am languid, holding day at bayuntil the soundscape of swelling bird song and coffee grindingpierce somnolence, and I take my seat by morning's window.yourself to meet the world, is never sated. I listen, not yet primed... Author, Article, and Disclosure InformationAuthors: Sylvia S. Villarreal, MEd, MPHAffiliations: McGovern Center for Humanities and Ethics Houston, TexasCurrent Author Address: Sylvia S. Villarreal, MEd, MPH, 6431 Fannin Street, Suite JJL 410, Houston, TX 77030; e-mail, Sylvia.S.[email protected].tmc.edu. PreviousarticleNextarticle Advertisement Audio Reading - “Morning Groove” Audio. Virginia L. Hood, MD, a physician from the University of Vermont, reads “Morning Groove” by Sylvia S. Villarreal, MEd, MPH Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics February 2022Volume 175, Issue 2Page: 298 ePublished: 15 February 2022 Issue Published: February 2022 Copyright & PermissionsCopyright © 2022 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Special Article
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ALBUMINURIA OF PUBERTY.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Targeted next-generation sequencing of circulating free DNA enables non-invasive tumor detection in myxoid liposarcomas
Authors: A. E. Eisenhardt, A. Schmid, J. Esser, Z. Brugger, U. Lausch, J. Kiefer, M. Braig, A. Runkel, J. Wehrle, R. Claus, P. Bronsert, A. Leithner, B. Liegl-Atzwanger, J. Zeller, R. Papini, M. von Laffert, B. M. Pfitzner, G. Koulaxouzidis, R. E. Giunta, S. U. Eisenhardt, David Braig
Journal: Molecular Cancer (2022)
Manuscripts Approved for JNCI During July-August 1976
Journal: JNCI Journal of the National Cancer Institute (1976)

Manuscripts Approved for JNCI During July-August 1976 Get access JNCI: Journal of the National Cancer Institute, Volume 57, Issue 3, September 1976, Pages 737–738, https://doi.org/10.1093/jnci/57.3.737-a Published: 01 September 1976
Medical Ethics
Authors: Lester S. King
Journal: JAMA (1970)

Constantly we are called upon to choose between two or more courses of conduct. Some decisions we make simply from habit, others from desire or impulse or perhaps whim, still others from motives of prudence. However, some choices involve the quite special concepts that we call right and wrong, and decisions of this type, the situations that give rise to them, and the principles on which the choice is made, comprise the realm of ethics. We find great difficulty if we try to define right and wrong. To be sure, for some people the boundary is so sharp that it leaves no room for doubt, but for most of us the borders are fuzzy. The more we reflect the more uncertain we get, and any general rules seem to be shadowy and confused. The profession of medicine, dealing with health and disease, life and death, has its special ethical problems.