Assessment of Functional Mobility After COVID-19 in Adults Aged 50 Years or Older in the Canadian Longitudinal Study on Aging
Authors: Marla K. Beauchamp, Divya Joshi, Jacqueline McMillan, Urun Erbas Oz, Lauren E. Griffith, Nicole E. Basta, Susan Kirkland, Christina Wolfson, Parminder Raina, Andrew Costa, Laura Anderson, Cynthia Balion, Asada Yukiko, Benoȋt Cossette, Melanie Levasseur, Scott Hofer, Theone Paterson, David Hogan, Teresa Liu-Ambrose, Verena Menec, Philip St. John, Gerald Mugford, Zhiwei Gao, Vanessa Taler, Patrick Davidson, Andrew Wister, Theodore Cosco
Journal: JAMA Network Open (2022)

<h3>Importance</h3> The association of COVID-19 not requiring hospitalization with functional mobility in community-dwelling adults above and beyond the impact of the pandemic control measures implemented in 2020 remains to be elucidated. <h3>Objective</h3> To evaluate the association between a COVID-19 diagnosis and change in mobility and physical function of adults in Canada aged 50 years or older during the initial pandemic lockdown. <h3>Design, Setting, and Participants</h3> This population-based cohort study used data from the Canadian Longitudinal Study on Aging (CLSA) COVID-19 study. This study was launched on April 15, 2020, and the exit questionnaires were completed between September and December 2020. Prepandemic data from the first CLSA follow-up (2015-2018) were also used. Respondents included middle-aged and older community-dwelling participants residing in Canadian provinces. Data were analyzed from February to May 2021. <h3>Exposures</h3> The assessment for self-reported COVID-19 status was adapted from the Public Health Agency of Canada and the Centers for Disease Control and Prevention case definition available at the time of data collection; cases were classified as confirmed or probable, suspected, or non–COVID-19. <h3>Main Outcomes and Measures</h3> Changes in mobility since the start of the COVID-19 pandemic were assessed using global rating of change in mobility scales at the COVID-19 exit questionnaire. Participant-reported new onset of difficulty in 3 physical function tasks was also examined. <h3>Results</h3> Among 51 338 participants at baseline, 21 491 participants (41.9%) were 65 years or older and 26 155 participants (51.0%) were women and 25 183 (49.1%) were men. Of 24 114 participants who completed the COVID-19 exit questionnaire, 2748 individuals had confirmed, probable or suspected COVID-19. Of 121 individuals with confirmed or probable COVID-19, 113 (93.3%) were not hospitalized. Individuals with confirmed or probable COVID-19 had higher odds of worsening mobility in terms of ability to engage in household activity (odds ratio [OR], 1.89; 95% CI, 1.11-3.22), physical activity (OR, 1.91; 95% CI, 1.32-2.76), and standing up after sitting in a chair (OR, 2.33; 95% CI, 1.06-5.11) compared with adults without COVID-19 during the same pandemic time period. Similar results were found for suspected COVID-19 status (eg, household activity: OR, 2.09; 95% CI, 1.82-2.41). <h3>Conclusions and Relevance</h3> This cohort study among older adults in Canada found that receiving a COVID-19 diagnosis was significantly associated with worse mobility and functioning outcomes even in the absence of hospitalization. These findings suggest that interventions may be needed for individuals with mild to moderate COVID-19 who do not require hospitalization.