tbuckley/cabot-search huggingface dataset:
VARIOLA.
Authors: H. M. BRACKEN
Journal: JAMA (1901)

This disease has prevailed so generally throughout the United States since 1897 that time spent in describing it might well be considered wasted. That it has been remarkably mild in type every one who has had any experience knows, but in spite of this fact experts are practically a unit in their diagnosis. I am aware that at Atlantic City a year ago a member of this Association presented a paper, with a title made up largely of interrogation points, in which he attempted to prove that the disease as he had seen it in Tennessee was not variola, but this paper had not a single convincing argument to those who have had an opportunity of studying the disease, that it was anything else than variola. In spite of the fact that this disease of mild type was epidemic in Kentucky and other Southern States in 1897; was well described
Incidence of hepatotoxicity in patients with hepatocellular carcinoma on treatment with immune checkpoint inhibitors: impact on outcomes and tissue biomarker analysis
Authors: Nicola Personeni, Tiziana Pressiani, Antonio D’Alessio, Luca Di Tommaso, Maria Giuseppina Prete, Silvia Bozzarelli, Valeria Smiroldo, Arianna Dal Buono, Antonio Capogreco, Alessio Aghemo, Ana Lleo, Romano Fabio Lutman, Massimo Roncalli, Laura Giordano, Armando Santoro, Lorenza Rimassa
Journal: Journal of Hepatology (2020)
Reproductive toxicology. Ethylene glycol.
Authors: James Lamb, Ntp Niehs, Dushyant Gulati, Leta Hommel, Marian Welch
Journal: Environmental Health Perspectives (1997)

numerous other consumer products, was tested for reproductive toxicity in Swiss CD-1 mice using the RACB protocol (Lamb et al., Toxicol Appl Pharmacol 81:100-112 [1985]).This study in particular was conducted as a follow-up to a previous EG study.This study used a higher top dose, and incorporated a crossover mating, and an evaluation of all dose levels in Fis.Based on the data from
Fatality following metallic mercury aspiration during removal of a long intestinal tube
Authors: J. E. Zimmerman
Journal: JAMA (1969)

A 48-year-old man died following aspiration of metallic mercury during removal of a Miller-Abbott tube. Death resulted from massive endobronchial hemorrhage and was preceded by symptoms and signs of mercury poisoning. Metallic mercury may cause serious local and systemic effects when introduced parenterally. Prompt therapy with dimercaprol (BAL) combined with surgical excision where practical are recommended when these effects are detected.
Gulf illness
Authors: P Beale
Journal: BMJ (1994)

to fast and efficient relief of acute headaches, but the patients had to use it daily or almost daily (in one case altemating it with ergot preparations) to prevent recurrence.Treatment consisted of abrupt withdrawal of sumatriptan and introduction of prophylaxis against migraine.Subsequently, daily headaches resolved in all patients.All of these patients had a long history of misuse of drugs for migraine and were misusing those drugs when they switched to regular use of suma- triptan.Therefore our data provide no evidence that sumatriptan has addictive properties in patients without a history of uncritical use of drugs for headache.Possibly, however, sumatriptan has a similar risk of misuse to that associated with analgesics and ergot compounds in people with chronic headache with previous drug dependency.The long term effects of daily use of sumatriptan are unknown.Although sumatriptan given for 7-10 days alleviated rebound headache when ergot preparations were withdrawn in a small number of patients who misused them,4 this finding needs confirmation.Sumatriptan is approved only for the treatment of acute migraine attacks.We believe that it should not be prescribed to patients who are taking analgesics and ergot compounds daily and should be prescribed with caution to patients with a history of misuse of analgesics and ergot com- pounds.
Audit of the hospital formulary. For duplication of equally effective analogues of antimicrobial agents
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Expression of Inducible Nitric Oxide Synthase and Formation of Nitric Oxide by Alveolar Macrophages: An Interspecies Comparison
Authors: Natalie K. Jesch, Martina Dorger, Georg Enders, Gabriele Rieder, Claus Vogelmeier, Konrad Messmer, Fritz Krombach
Journal: Environmental Health Perspectives (1997)
Phase I study of ZEN-008 (AN-152), a targeted cytotoxic LHRH analog, in female patients with cancers expressing LHRH receptors
Authors: G. Emons, M. Kaufmann, A. Günthert, C. Gründker, S. Loibl, V. I. Tzekova, M. T. Velikova, S. Tomov, H. Sindermann, J. Engel, A. V. Schally
Journal: Journal of Clinical Oncology (2007)

3571 Background: Human ovarian, endometrial, and breast cancers commonly express receptors for luteinizing hormone releasing hormone (LHRH-R). LHRH-R can be used for targeted chemotherapy with ZEN-008 (AN-152), in which doxorubicin (DOX) is linked to [D-Lys(6)]- LHRH. Preclinical studies showed a significantly reduced cardiotoxic potential of ZEN-008 compared with DOX, as well as activity in multi-drug resistant tumor models. This study assessed dose limiting toxicities (DLTs), maximum tolerated dose (MTD), and pharmacokinetics (PK) of ZEN- 008 given once every 3 weeks in female patients. Methods: Patients (pts) with tumors proven immunohistochemically to be LHRH- R positive and had progressive disease following chemotherapy were eligible if prior therapy did not exceed 70% of the recommended maximum lifetime dose for DOX. Starting at 10 mg/m 2 , doses were doubled between pts until side effects of CTCAE grade 2 or higher, then escalation following a modified Fibonacci scheme, with 3–6 pts/group. Safety monitoring included pituitary and cardiac function. Response evaluation followed the RECIST criteria. HPLC with fluorescence detection was used for plasma PK of ZEN-008 and free DOX. Results: Seventeen pts (13 with ovarian, 2 with breast cancer) received ZEN-008 by intravenous infusion over 2 hours at dosages of 10, 20, 40, 80 mg/m 2 (1 pt and 2 cycles each). At 160 mg/m 2 6 pts had 24 cycles, 1 pt ongoing at 3+ cycles), and at 267 mg/m 2 7 pts had a total of 30 cycles, 1 pt ongoing at 4+ cycles). Short-lasting leukopenia/neutropenia of CTCAE Grade 4 was dose limiting in 2 pts at 267 mg/m 2 . One pt at this dose level had an allergic skin reaction during infusion, subsequent cycles with anti-allergic pre-medication were tolerated. At 160 mg/m 2 1 pt with ovarian cancer had CR (lymph node metastasis), at 267 mg/m 2 1 pat with ovarian cancer had a transient PR, and 3 pts had stable disease for 5+ cycles. PK analyses showed dose- dependent plasma levels of ZEN-008 and only minor (10–30%) release of DOX. Conclusions: Leukocytopenia was identified as a rapidly reversible DLT in heavily pretreated pts at a ZEN-008 dose of 267 mg/m 2 , given three-weekly, which is therefore also considered recommended Phase II dosage. Evidence of therapeutic activity was found at 160 and 267 mg/m 2 . [Table: see text]
Miscellanea Medica
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
STATE MEDICINE.
Authors: Irving A. Watson
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Books Received
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Life Review
Authors: Veneta Masson
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Elevated platelet-associated IgG in immune thrombocytopenic purpura associated with Waldenström's macroglobulinemia
Authors: Katsuya Yamamoto, Kaoru Nagata, Hiroyuki Hamaguchi
Journal: American Journal of Hematology (2002)

Heparin-induced thrombocytopenia (HIT), characterized by the formation of antibodies to a complex of platelet factor 4 (PF4) and heparin, is a well-recognized risk factor for thromboembolic complications. The frequency of antibody development varies among patient populations. Hemodialysis patients have repeated heparin exposure and should be at risk of developing HIT. This might, contribute to the development of vascular access thrombosis. We prospectively evaluated 88 hemodialysis patients for the presence of anti-PF4/heparin antibodies. Eighteen patients (20%) had a prior history of 1 or more prior access thrombosis. One patient (1.14%), without a history of graft thrombosis, tested positive for anti-PF4/heparin antibodies. In our study, the presence of anti-PF4/heparin antibodies was rare and was not increased in patients with a history of vascular access thrombosis. Am. J. Hematol. 69:72-73, 2002. © 2002 Wiley-Liss, Inc.
Abstracts
Authors: None &NA;
Journal: Clinical Nuclear Medicine (2000)

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The Vaccination Bill
Authors: S. Gibbon
Journal: BMJ (1866)

<h3>Abstract</h3> Myocardial damage caused by the newly emerged coronavirus (SARS-CoV-2) infection is one of key determinants of COVID-19 severity and mortality. SARS-CoV-2 entry to host cells are initiated by binding with its receptor, angiotensin converting enzyme (ACE) 2, and the ACE2 abundance is thought to reflect the susceptibility to infection. Here, we found that clomipramine, a tricyclic antidepressant, potently inhibits SARS-CoV-2 infection and metabolic disorder in human iPS-derived cardiomyocytes. Among 13 approved drugs that we have previously identified as potential inhibitor of doxorubicin-induced cardiotoxicity, clomipramine showed the best potency to inhibit SARS-CoV-2 spike glycoprotein pseudovirus-stimulated ACE2 internalization. Indeed, SARS-CoV-2 infection to human iPS-derived cardiomyocytes (iPS-CMs) and TMPRSS2-expressing VeroE6 cells were dramatically suppressed even after treatment with clomipramine. Furthermore, the combined use of clomipramine and remdesivir was revealed to synergistically suppress SARS-CoV-2 infection. Our results will provide the potentiality of clomipramine for the breakthrough treatment of severe COVID-19.
'Pacemaker' studied for impotence
Authors: T. Hager
Journal: JAMA (1983)

By some estimates, as many as 10 million men in the United States may be experiencing some form of impotence. At the recent American Urological Association meeting in Las Vegas, Tom F. Lue, MD, and co-workers Richard A. Schmidt, MD, and Emil A. Tanagho, MD, at the University of California, San Francisco, School of Medicine, reported that they have developed a system for studying the physiology of erections under controlled conditions in lower primates. The key was the discovery, after a six-month search, of several bundles of "basically parasympathetic" nerves posterolateral to the prostate of monkeys. These bundles, the researchers say, can trigger erections when electrically stimulated. By surgically implanting small electrodes that are activated via radio signals, Lue's group is able to induce and maintain erections in the animals for periods up to several hours. "People have said that the erect penis is a closed system, but that's not true,"
Protein Tyrosine Phosphatase-Sigma (PTPσ) Regulates Hematopoietic Stem Cell Repopulating Capacity
Authors: Mamle Quarmyne, Phuong L. Doan, Heather A. Himburg, Xiao Yan, Liman Zhao, Nelson J. Chao, John P. Chute
Journal: Blood (2014)
MALARIA.
Authors: ERWIN F. SMITH
Journal: JAMA (1884)

In connection with the recent discussion of malaria ria by the American Public Health Association, it is interesting to note the conclusions reached by Prof. feverommasi-Crudeli, of the University of Rome, as to the causation and prophylaxis of fever and ague. These conclusions, first published some years since, have beeen reaffirmed recently in a study on “The Preservation of Man in Malarial Regions,” published by the Italian government. Tommasi-Crudeli believes malarial fevers are caused by a bacteric ferment which grows in the soil, and thence finds its way into the air. Both he and Klebs think they have discovered a specific intermittent germ, which they have christened bacillus malariæ. This germ is not of necessity paludal in origin. He seems to have established beyond a doubt that there is no cognate relation between marshes and malaria—some marshes, though filled with decomposing vegetation, are innocent, while many comparatively dry and even
Early anterior fusion for injuries of the cervical portion of the spine
Authors: H. Norrell
Journal: JAMA (1970)

The anterior approach to cervical spine fractures and dislocations offers a unique opportunity for the surgeon to directly visualize and treat the lesion producing spinal cord compression, whether it be a herniated disk or bony fragment from the vertebral body. At the same time the spinal instability may be corrected by a vertebral interbody fusion. If the vertebral body has been crushed, it is possible to replace it, preventing the deformity and instability which might produce further damage to the spinal cord. The problems attending prolonged immobilization in skull traction, the traditional management of cervical spine fractures, are avoided and active rehabilitation is instituted immediately following surgery reducing the time required for bed treatment.
Associations Among School Absenteeism, Gastrointestinal and Respiratory Illness, and Income — United States, 2010–2016
Authors: David Berendes, Ashley Andujar, Lisa C. Barrios, Vincent Hill
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

Control of communicable diseases in children, including respiratory and diarrheal illnesses that affect U.S. school-aged children, might require public health preventive efforts both in the home and at school, a primary setting for transmission. National Health Interview Survey (NHIS) data on school absenteeism and gastrointestinal and respiratory illnesses in the United States during 2010-2016 were analyzed to examine their associations with income. Prevalence of gastrointestinal and respiratory illnesses (queried for the 2 weeks preceding the survey) increased as income decreased. The likelihood of missing any school days during the past year decreased with reduced income. However, among children who missed school, those from low-income households missed more days of school than did children from higher income households. Although the reason for absenteeism cannot be ascertained from this analysis, these data underscore the importance of preventive measures (e.g. hand hygiene promotion and education) and the opportunity for both homes and schools to serve as important points for implementation of public health preventive measures, including improved hand hygiene practices.
"Psychosomatic Illness"
Authors: E. K. Mackenzie
Journal: BMJ (1938)

<h3>Background and objectives</h3> Patients are informed of the risk of kidney biopsy–related complications using data from nonhospitalized patients, which may underestimate the risk for hospitalized patients. We evaluated the rate and risk factors of kidney biopsy–related complications in hospitalized patients with acute kidney disease (AKD) to better estimate the risk in this population. <h3>Design, setting, participants, &amp; measurements</h3> We used data from the Yale biopsy cohort to evaluate rates of kidney biopsy–related complications including adjudicated procedure-related bleeding requiring blood transfusions or angiographic interventions, medium- or large-sized hematomas, reimaging after biopsy including abdominal ultrasonography or computed tomography, and death in hospitalized patients with AKD (including AKI). We evaluated univariable and multivariable association of risk factors with transfusions. We compared rates of complications between hospitalized and nonhospitalized patients. <h3>Results</h3> Between 2015 and 2017, 159 hospitalized patients underwent a kidney biopsy for AKD evaluation, of which 80 (51%) had stage 1 AKI, 42 (27%) had stage 2 (or higher) AKI, and 27 (17%) had AKD (without AKI). Of these, 12 (8%; 95% confidence interval [95% CI], 5% to 15%) required a transfusion, three (2%; 95% CI, 1% to 5%) required an intervention, 11 (7%; 95% CI, 4% to 12%) had hematoma, and 31 (20%; 95% CI, 14% to 26%) required reimaging after biopsy. Of the four (3%; 95% CI, 1% to 6%) deaths during hospitalization, none were related to the biopsy. Female sex, lower platelet count, and higher BUN were associated with postbiopsy transfusions on univariable and multivariable analyses. Trainee as proceduralist and larger needle gauge were associated with transfusions in univariable, but not multivariable, analysis. Nonhospitalized patients had lower rates of transfusion than hospitalized patients, although the latter also had lower prebiopsy hemoglobin and greater surveillance after biopsy. <h3>Conclusions</h3> Hospitalized patients experience higher risk of postbiopsy complications than previously reported and several factors, such as lower platelet count, female sex, and higher BUN, are associated with this risk.