tbuckley/cabot-search huggingface dataset:
Манодебитометрия в интраоперационной диагностике внепеченочного холестаза при осложненном холелитиазе
Authors: B.F. Shevchenko, O.V. Zeleniuk, O.M. Babii, N.V. Prolom, О.О. Galinsky
Journal: GASTROENTEROLOGY (2020)

Цель работы: оценить эффективность применения комбинированной методики манодебитометрии в интра­операционной диагностике причин различных типов внепеченочного холестаза (ВХС) при осложненном холелитиазе. Материалы и методы. Манодебитометрия проведена у 181 больного, которые были прооперированы в отделении хирургии органов пищеварения ГУ «Институт гастроэнтерологии НАМН Украины» за период с 2013 по 2020 г. с помощью разработанного программно-аппаратного комплекса. Всем больным до операции выполняли: ультразвуковое исследование, при подозрении на холедохокалькулез — эндоскопическую ретроградную холангиопанкреатографию и магнитно-резонансную холангиопанкреатографию. Также оценивали моторно-эвакуаторную функцию желчного пузыря. Результаты. В зависимости от наличия биохимических маркеров желтухи и повреждения гепатоцитов, а также предикторов холестаза в анамнезе больные распределены на 5 групп внепеченочного холестаза. Использование комбинированной методики манодебитометрии в интраоперационной диагностике главных причин различных типов ВХС при осложненном холелитиазе позволило диагностировать органическое нарушение как причину развития ВХС у 34 (18,78 %) больных и у 38 (20,99 %) — функциональные нарушения сфинктера Одди. Проведение ROC-анализа применения комбинированной методики манодебитометрии в качестве диагностического скрининга функциональной и органической причины ВХС при осложненном холелитиазе позволило установить высокое качество диагностической модели с использованием определенного коэффициента в качестве оптимального порога классификации с точностью 88,9 %, чувствительностью 93,6 %, специфичностью 80 %, тогда как площадь под кривой ROC составляла 0,9311 (95% доверительный интервал 0,918–0,929; р &lt; 0,0001). Выводы. Применение манодебитометрического исследования холедоха с фармакологическим тестом на расслабление во время операции позволяет увеличить на 34,8 % выявление причин ВХС при осложненном холелитиазе, обнаружить его дисфункцию и может быть рекомендовано к практическому применению для распознавания типов ВХС, его главных причин и интраоперационного определения показаний к их коррекции во время операции.
Everolimus
Authors: Peter J. Houghton
Journal: Clinical Cancer Research (2010)

Abstract Everolimus, an orally administered rapamycin analog, has recently been approved by the U.S. Food and Drug Administration for treatment of renal cell carcinoma (RCC) refractory to inhibitors of vascular endothelial growth factor (VEGF) receptor signaling. Everolimus significantly increased progression-free survival (median PFS for the everolimus treated group was 4.0 months versus 1.9 months for the placebo group), although tumor regressions were observed only infrequently. Although the target for everolimus, [the serine-threonine kinase mammalian target of rapamycin (mTOR)] is well established, the mechanism by which this agent retards tumor growth is not well defined. Further, biomarkers that predict tumor sensitivity are still elusive. The mechanism of action, preclinical antitumor activity, and clinical activity of everolimus against RCC are reviewed. Clin Cancer Res; 16(5); 1368–72
Abstract 15184: Diabetes Has a Strong Effect on the Progression of Atherosclerosis Independent of Metabolic Syndrome
Authors: Ki-Bum Won, Hyuk-Jae Chang, Han-Chul Lee, Sung-Ha Park, Sang-Hak Lee, YangSoo Jang
Journal: Circulation (2012)

Introduction: Metabolic syndrome (MS) and diabetes are important risk factors for atherosclerotic cardiovascular disease. Hypothesis: We assessed the hypothesis that the effect of MS to the progres...
‘Adhesion and release’ nanoparticle-mediated efficient inhibition of platelet activation disrupts endothelial barriers for enhanced drug delivery in tumors
Authors: Jinxu Cao, Peng Yang, Pengzhen Wang, Shuting Xu, Yunlong Cheng, Kang Qian, Minjun Xu, Dongyu Sheng, Yixian Li, Yan Wei, Qizhi Zhang
Journal: Biomaterials (2020)
Statin treatment and muscle symptoms: series of randomised, placebo controlled n-of-1 trials
Authors: Emily Herrett, Elizabeth Williamson, Kieran Brack, Danielle Beaumont, Alexander Perkins, Andrew Thayne, Haleema Shakur-Still, Ian Roberts, Danielle Prowse, Ben Goldacre, Tjeerd van Staa, Thomas M MacDonald, Jane Armitage, Jon Wimborne, Paula Melrose, Jayshireen Singh, Lucy Brooks, Michael Moore, Maurice Hoffman, Liam Smeeth
Journal: BMJ (2021)

To establish the effect of statins on muscle symptoms in people who had previously reported muscle symptoms when taking statins.Series of randomised, placebo controlled n-of-1 trials.Primary care across 50 sites in the United Kingdom, December 2016 to April 2018.200 participants who had recently stopped or were considering stopping treatment with statins because of muscle symptoms.Participants were randomised to a sequence of six double blinded treatment periods (two months each) of atorvastatin 20 mg daily or placebo.At the end of each treatment period, participants rated their muscle symptoms on a visual analogue scale (0-10). The primary analysis compared symptom scores in the statin and placebo periods.151 participants provided symptoms scores for at least one statin period and one placebo period and were included in the primary analysis. Overall, no difference in muscle symptom scores was found between the statin and placebo periods (mean difference statin minus placebo -0.11, 95% confidence interval -0.36 to 0.14; P=0.40)). Withdrawals because of intolerable muscle symptoms were 18 participants (9%) during a statin period and 13 (7%) during a placebo period. Two thirds of those completing the trial reported restarting long term treatment with statins.No overall effect of atorvastatin 20 mg on muscle symptoms compared with placebo was found in participants who had previously reported severe muscle symptoms when taking statins. Most people completing the trial intended to restart treatment with statins. N-of-1 trials can assess drug effects at the group level and guide individual treatment.ISRCTN30952488, EUDRACT 2016-000141-31, NCT02781064.
Directional Coronary Atherectomy and Implantation of Drug-Eluting Stents in Selected Bifurcation Lesions: A Logical Combination Waiting Evidence⁎⁎Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Authors: Antonio Colombo
Journal: Journal of the American College of Cardiology (2007)
H3K27me3 loss indicates an increased risk of recurrence in the Tübingen meningioma cohort
Authors: Felix Behling, Christina Fodi, Irina Gepfner-Tuma, Kristina Kaltenbach, Mirjam Renovanz, Frank Paulsen, Marco Skardelly, Jürgen Honegger, Marcos Tatagiba, Jens Schittenhelm, Ghazaleh Tabatabai
Journal: Neuro-Oncology (2020)

A loss of the trimethylation of lysine 27 of histone H3 (H3K27me3) in meningioma has been recently suggested as an adjunct to identify subsets of higher risk of recurrence. The aim of the present study was to assess the prognostic value of H3K27 histone trimethylation and its potential clinical utility in the "Tübingen meningioma cohort."Patients who underwent meningioma resection between October 2003 and December 2015 at the University Hospital Tübingen were included. Immunohistochemical stainings for H3K27me3 and the proliferation marker MIB1 were assessed and correlated with clinical parameters using univariate and multivariate Cox regressions as well as Pearson's chi-squared and log-rank test.Overall, 1268 meningiomas were analyzed with a female to male ratio of 2.6 and a mean age of 58.7 years (range 8.3-91.0). With 163 cases lost to follow up, 1103 cases were available for further analysis with a mean follow-up of 40.3 months (range 1.1-186.3). Male gender, younger age, intracranial tumor localization, progressive tumor, subtotal resection, higher WHO grade, increased MIB1 rate, and loss of H3K27me3 were significant negative prognostic factors in the univariate analysis. H3K27me3 status and all other prognostic factors, except age and tumor location, remained significant in the multivariate model. Furthermore, adjuvant radiotherapy was an independent positive prognostic factor.Loss of H3K27me3 combined with MIB1 labeling index are independent prognostic factors in meningioma. These data from the Tübingen meningioma cohort support the clinical utility of H3K27me3 immunohistochemical staining in meningioma and its integration into the routine histopathological workup.
Induction of autophagy mitigates TDP-43 pathology and translational repression of neurofilament mRNAs in mouse models of ALS/FTD
Authors: Sunny Kumar, Daniel Phaneuf, Pierre Cordeau, Hejer Boutej, Jasna Kriz, Jean-Pierre Julien
Journal: Molecular Neurodegeneration (2021)

Abstract Background TDP-43 proteinopathy is a pathological hallmark of many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). So far, there is no therapy available for these neurodegenerative diseases. In addition, the impact of TDP-43 proteinopathy on neuronal translational profile also remains unknown. Methods Biochemical, immunohistology and assay-based studies were done with cell cultures and transgenic mice models. We also used Ribotag with microarray and proteomic analysis to determine the neuronal translational profile in the mice model of ALS/FTD. Results Here, we report that oral administration of a novel analog (IMS-088) of withaferin-A, an antagonist of nuclear factor kappa-B (NF-ĸB) essential modulator (NEMO), induced autophagy and reduced TDP-43 proteinopathy in the brain and spinal cord of transgenic mice expressing human TDP-43 mutants, models of ALS/FTD. Treatment with IMS-088 ameliorated cognitive impairment, reduced gliosis in the brain of ALS/FTD mouse models. With the Ribotrap method, we investigated the impact of TDP-43 proteinopathy and IMS-088 treatment on the translation profile of neurons of one-year old hTDP-43 A315T mice. TDP-43 proteinopathy caused translational dysregulation of specific mRNAs including translational suppression of neurofilament mRNAs resulting in 3 to 4-fold decrease in levels type IV neurofilament proteins. Oral administration of IMS-088 rescued the translational defects associated with TDP-43 proteinopathy and restored the synthesis of neurofilament proteins, which are essential for axon integrity and synaptic function. Conclusions Our study revealed that induction of autophagy reduces TDP-43 pathology and ameliorates the translational defect seen in mice models of ALS/FTD. Based on these results, we suggest IMS-088 and perhaps other inducers of autophagy should be considered as potential therapeutics for neurodegenerative disorders with TDP-43 proteinopathies.
177Lu-DOTA-EB-TATE, a Radiolabeled Analogue of Somatostatin Receptor Type 2, for the Imaging and Treatment of Thyroid Cancer
Authors: Shilpa Thakur, Brianna Daley, Corina Millo, Craig Cochran, Orit Jacobson, Huiyan Lu, Zhantong Wang, Dale Kiesewetter, Xiaoyuan Chen, Vasyl Vasko, Joanna Klubo-Gwiezdzinska
Journal: Clinical Cancer Research (2020)

The goal of this study was to analyze the role of somatostatin receptor type 2 (SSTR2) as a molecular target for the imaging and treatment of thyroid cancer through analysis of SSTR2 expression and its epigenetic modulation and testing tumor uptake of different radiolabeled SSTR2 analogues.We analyzed SSTR2 expression by immunostaining of 92 thyroid cancer tissue samples and quantified standard uptake values (SUVmax) of SSTR2 analogue, 68Ga-DOTA-TATE, by PET/CT imaging in 25 patients with metastatic thyroid cancer. We utilized human thyroid cancer cell lines characterized by differential SSTR2 expression (TT, BCPAP, and FTC133) and rat pancreatic cell line (AR42J) with intrinsically high SSTR2 expression for functional in vitro studies. SSTR2-high (AR42J) and SSTR2-low (FTC133) xenograft mouse models were used to test the uptake of radiolabeled SSTR2 analogues and their therapeutic efficacy in vivo.Thyroid cancer had a higher SSTR2 expression than normal thyroid. Hurthle cell thyroid cancer was characterized by the highest 68Ga-DOTA-TATE uptake [median SUVmax, 16.5 (7.9-29)] than other types of thyroid cancers. In vivo studies demonstrated that radiolabeled DOTA-EB-TATE is characterized by significantly higher tumor uptake than DOTA-TATE (P < 0.001) and DOTA-JR11 (P < 0.001). Treatment with 177Lu-DOTA-EB-TATE extended survival and reduced tumor size in a mouse model characterized by high somatostatin (SST) analogues uptake (SUVmax, 15.16 ± 4.34), but had no effects in a model with low SST analogues uptake (SUVmax, 4.8 ± 0.27).A novel SST analogue, 177Lu-DOTA-EB-TATE, has the potential to be translated from bench to bedside for the targeted therapy of patients characterized by high uptake of SST analogues in metastatic lesions.
Excess Mortality in California During the Coronavirus Disease 2019 Pandemic, March to August 2020
Authors: Yea-Hung Chen, M. Maria Glymour, Ralph Catalano, Alicia Fernandez, Tung Nguyen, Margot Kushel, Kirsten Bibbins-Domingo
Journal: JAMA Internal Medicine (2020)

from COVID-19 with 2 negative RT-PCR test results 24 hours apart.At a mean of 48.6 days from their date of diagnosis, 32 patients (18.2%) had a positive PCR test result for SARS-CoV-2 RNA.Using a specialized assay, only 1 of these 32 patients (3.1%) had evidence of RNA capable of replication.Although this study cannot solve the challenge of interpreting positive PCR results in recovered patients, the data help us to better understand the scope of the problem.To avoid unnecessary quarantine for patients who have recovered from COVID-19, routine repeated PCR testing should not be done in the 90 days following infection.However, more complicated is what to do about patients who are symptomatic and have positive results on repeated PCR tests.Reinfection with SARS-CoV-2 has been documented 2 (based on demonstration of different genetic differences between the viruses infecting the person on the first and second episode) but is rare.Until clinical laboratories have the capability to test for the reproductive capacity of coronavirus, interpretation of the epidemiologic significance of positive PCR results among recovered patients will remain challenging.
Controlling cancer-induced inflammation with a nucleic acid scavenger prevents lung metastasis in murine models of breast cancer
Authors: Eda K. Holl, Victoria Frazier, Karenia Landa, David Boczkowski, Bruce Sullenger, Smita K. Nair
Journal: Molecular Therapy (2020)

Tumor cells release nucleic acid-containing proinflammatory complexes, termed nucleic acid-containing damage-associated molecular patterns (NA DAMPs), passively upon death and actively during stress. NA DAMPs activate pattern recognition receptors on cells in the tumor microenvironment leading to prolonged and intensified inflammation that potentiates metastasis. No strategy exists to control endogenous or therapy-induced inflammation in cancer patients. We discovered that the generation 3.0 polyamidoamine dendrimer (PAMAM-G3) scavenges NA DAMPs and mitigates their proinflammatory effects. In this study, we tested if the nucleic acid scavenger (NAS) PAMAM-G3 reduces lung metastasis in murine models of breast cancer. Our data indicate that PAMAM-G3 treatment decreases cell-free DNA levels and reduces lung metastasis in the experimental intravenous tumor-injection model and the postsurgical tumor-resection model of 4T1 breast cancer. Reduction in lung metastasis is associated with reduction in inflammatory immune cell subsets and proinflammatory cytokine levels in the tumor and the periphery. This study is the first example of NAS-mediated inhibition of metastasis to the lung. The study results provide a strong rationale for inclusion of NAS therapy in women with breast cancer undergoing standard-of-care surgery.
Total Pericardiectomy via Modified Left Anterolateral Thoracotomy without Cardiopulmonary Bypass (UKC’s Modification): A Video Presentation
Authors: Ujjwal Chowdhury
Journal: Clinical Cardiology and Cardiovascular Interventions (2020)

We report one male patient aged 28-years undergoing total pericardiectomy for chronic calcific pericarditis with an uneventful postoperative course. The step-by-step surgical procedure of total pericardiectomy via modified left anterolateral thoracotomy without utilizing cardiopulmonary bypass has been detailed.
Considerations for Developing an Agenda for Gun Violence Prevention Research
Authors: Mark Rosenberg
Journal: Annual Review of Public Health (2020)

In December 2019, for the first time in more than 20 years, the US Congress appropriated, and the president signed, a bill that included $25 million for gun violence prevention research at the Centers for Disease Control and Prevention and the National Institutes of Health. This research should find ways to reduce injury, death, and suffering while protecting the right of law-abiding citizens to own firearms. Four questions can structure this research agenda. First, what is the problem: How many people get shot, who are they, where does it happen, what is the relationship between the shooter and the victim, what other types of damage are incurred, and are the shootings increasing or decreasing? Second, what are the causes: What is the role of alcohol and drugs; what is the role of gangs, poverty, and systemic racism; what is the role of mental illness, robbery, and domestic violence; what is the role of private gun ownership (both positive and negative) and easy access to guns? What are the factors that protect us, such as stable families and safe environments? Third, what works: Which practices, interventions, policies, and laws work best to prevent these deaths and injuries? And fourth, how do you do it: How do you implement the findings and translate them into policies, legislation, and practices that can be scaled up?
For the Necessary: You
Authors: Ellen Zhang
Journal: JAMA Oncology (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Abstract 15525: Morphology of Calcification on Culprit Site: A Significant Indicator of Plaque Erosion in Acute Coronary Syndrome
Authors: Michiaki NAGAI, Keigo Dote, Masaya Kato, Noboru Oda, Eiji Kunita, Eisuke Kagawa, AYA YAMANE, Hiroshi Kobatake, Haruko Shiota, Ayano Osawa, Naoki Ishibashi, Kazuki Takahashi
Journal: Circulation (2020)

Introduction: While clinical predictors of plaque erosion (PE) in patients with acute coronary syndromes (ACS) were reported, PE was more frequently observed in the population with normal kidney function. On the other hand, earlier studies indicated that spotty calcification related to plaque rupture on the culprit site in ACS. However, the morphological features of coronary calcification on culprit site have not been investigated in relation to PE. Hypothesis: We assessed the hypothesis that the morphology of calcification on culprit site was associated with PE in ACS patients without chronic kidney disease (CKD). Methods: In the 166 ACS patients (66.9±10.7 years old, male 83 %), based on Optical Coherence Tomography/ Optical Frequency Domain Imaging, existence of PE on culprit site was investigated. In the morphological features of coronary calcification, the maximum thickness, maximum area, maximum angle, minimum depth from the lumen in axial sections, and the length in longitudinal image were determined. Results: There were the 73 patients with PE, 58 patients with calcification and 38 patients with CKD. A marginal significant difference in thickness (300 vs 190μm, p=0.07) and significant difference in angle (60 vs 23degree, p=0.001), area (0.89 vs 0.43mm 2 , p=0.001) and length (2.34 vs 1.12 mm, p=0.03) were observed between the patients with PE and the patients without PE. In the multiple regression analysis adjustment for age, gender, region location, maximum creatine phosphokinase, STEMI or not, diabetes mellitus, angiotensin receptor blockers use, statin use and systolic blood pressure on admission, angle (OR: 1.01, 95%CI: 1.002 to 1.013, p=0.005) and area (OR: 1.46, 95%CI: 1.02 to 2.1, p=0.04) each had significant associations with PE. Specifically, only in the patients without CKD, thickness (p=0.025), angle (p=0.003) and area (p=0.013) were significant indicators of PE. Conclusions: In conclusion, morphology of calcification on culprit site was a significant indicator of PE in the patients with ACS. Specifically, larger calcification might serve as a pathophysiology underlying in the phenotype of plaque vulnerability in ACS patients with normal kidney function.
Ex vivo expanded, recipient-specific cytotoxic T lymphocytes plus CD8+ T-cell-depleted marrow to achieve engraftment in dog leukocyte antigen -haploidentical canine littermate recipients
Authors: A. G. Taranova, R. A. Nash, A. Nikitine, S. Heimfeld, B. Sandmaier, H. P. ter Kiem, R. F. Storb, G. E. Georges
Journal: Blood (2003)
Lymphocytes and the Immune Response
Authors: C. G. Craddock, Robert Longmire, Robert McMillan
Journal: New England Journal of Medicine (1971)

Marrow LymphopoiesisThe ultimate origin of both BL and TL is the bone marrow. Chromosomally marked marrow cells injected into lethally irradiated hosts proliferate in the thymus as well as in more peripherally located lymphoid structures,123 124 125 whereas cells derived from lymph nodes, thymus or thoracic-duct lymph repopulate the spleen and lymph nodes but are rarely identified in the thymus.126,127 Further observations have revealed that bone-marrow-derived lymphocytes regenerate in the thymus earlier than in the lymph nodes123,128; subsequent repopulation of lymph follicles occurs from cells leaving the thymus. It is probable that a blood-thymic "barrier" exists not only for dyes . . .
Fundus Pigmentation in the Diagnosis and Treatment of Retinopathy of Prematurity
Authors: Kenneth C. Fan, Sarah P. Read, Nimesh A. Patel, Elizabeth A. Vanner, Hasenin Al-khersan, Diana M. Laura, Parastou Pakravan, Catherin I. Negron, Audina M. Berrocal
Journal: Ophthalmology (2020)