tbuckley/cabot-search huggingface dataset:
Association of Number of Doses With Hepatitis B Vaccine Series Completion in US Adults
Authors: Katia Bruxvoort, Jeff Slezak, Runxin Huang, Bradley Ackerson, Lina S. Sy, Lei Qian, Kristi Reynolds, William Towner, Zendi Solano, Cheryl Mercado, Randall Hyer, Robert Janssen, Steven J Jacobsen
Journal: JAMA Network Open (2020)

<h3>Importance</h3> Receipt of hepatitis B virus vaccine is important to prevent infection. However, adherence to the hepatitis B vaccine series among adults at risk of infection has been low. <h3>Objective</h3> To assess whether recipients of a 2-dose hepatitis B vaccine with cytosine phosphoguanine adjuvant (HepB-CpG vaccine; Heplisav-B) are more likely to complete their series compared with recipients of a 3-dose vaccine with alum adjuvant (comparator vaccine; Engerix-B [HepB-alum]). <h3>Design, Setting, and Participants</h3> This nested cohort study was conducted from August 7 to December 31, 2018, at Kaiser Permanente Southern California, an integrated health care system with a diverse population of approximately 4.6 million members. Adults not receiving dialysis who received a first dose of a hepatitis B vaccine series in family practice or internal medicine departments of 15 Kaiser Permanente Southern California medical centers were followed up through electronic health records for up to 1 year after receipt of the first dose. Data were analyzed from March 16 to September 23, 2020. <h3>Exposures</h3> Receipt of a first dose of the HepB-CpG vaccine (2-dose vaccine) vs receipt of a first dose of the HepB-alum vaccine (3-dose vaccine). <h3>Main Outcomes and Measures</h3> Series completion within the recommended vaccine schedule plus 3 months (primary outcome) and series completion within 1 year after receipt of the first dose (secondary outcome). <h3>Results</h3> Of 4727 individuals who initiated the HepB-CpG vaccine series and 6161 individuals who initiated the HepB-alum vaccine series included in the study, 2876 (60.8%) and 3789 (61.5%), respectively, were ages 40 to 59 years, 2415 (51.1%) and 3113 (50.5%) were male, and 2364 (50.0%) and 2881 (46.8%) were Hispanic. The vaccine series was completed within the recommended schedule plus 3 months for 2111 (44.7%) individuals who initiated the HepB-CpG vaccine series and 1607 (26.1%) individuals who initiated the HepB-alum vaccine series, and within 1 year for 2858 (60.5%) and 1989 (32.3%) individuals, respectively. The individuals who initiated the HepB-CpG vaccine series were significantly more likely to complete the series (adjusted relative risk, 1.77; 95% CI, 1.68-1.87). Results were consistent across clinical and demographic strata. <h3>Conclusions and Relevance</h3> In this study, use of the HepB-CpG vaccine was associated with hepatitis B vaccine series completion, but tailored strategies to increase completion of hepatitis B vaccine series are warranted.
HDAC7 is a major contributor in the pathogenesis of infant t(4;11) proB acute lymphoblastic leukemia
Authors: Oriol de Barrios, Alexandros Galaras, Juan L. Trincado, Alba Azagra, Olga Collazo, Ainara Meler, Antonio Agraz-Doblas, Clara Bueno, Paola Ballerini, Giovanni Cazzaniga, Ronald W. Stam, Ignacio Varela, Paola De Lorenzo, Maria Grazia Valsecchi, Pantelis Hatzis, Pablo Menéndez, Maribel Parra
Journal: Leukemia (2020)
Long covid: doctors must assess and investigate patients properly
Authors: Amali U Lokugamage, Mary-Ann Bowen, Jennifer Blair
Journal: BMJ (2020)

Jensen’s article provides a poignant patient perspective and reflects well the experiences of many patients that were very sick at the peak of the first wave of covid-19 but were denied proper medical assessment and told to “stay at home.”1 Of course it is important to “show you care” and empathise with the patient. But, as part of an online group …
Microfluidic fabrication of inhalable large porous microspheres loaded with H2S-releasing aspirin derivative for pulmonary arterial hypertension therapy
Authors: Hui Zhang, Liu-Zhi Hao, Jian-An Pan, Qi Gao, Jun-Feng Zhang, Ranjith Kumar Kankala, Shi-Bin Wang, Ai-Zheng Chen, Hui-Li Zhang
Journal: Journal of Controlled Release (2020)
Clinical impact of a routine, molecular, point-of-care, test-and-treat strategy for influenza in adults admitted to hospital (FluPOC): a multicentre, open-label, randomised controlled trial
Authors: Tristan W Clark, Kate R Beard, Nathan J Brendish, Ahalya K Malachira, Samuel Mills, Cathleen Chan, Stephen Poole, Sean Ewings, Nick Cortes, Esther Nyimbili, Laura Presland
Journal: The Lancet Respiratory Medicine (2020)
Thromboembolic Complications of Annuloplasty Rings
Authors: Ratnasari Padang, Yehia Z Ali, Rekha Mankad, Melanie C Bois, Joseph F Maalouf, Lawrence J Sinak, Sorin V Pislaru, Vuyisile T Nkomo, Hector I Michelena, Sushil A Luis
Journal: JACC. Cardiovascular imaging (2020)
A Meal Detection Algorithm for the Artificial Pancreas: A Randomized Controlled Clinical Trial in Adolescents With Type 1 Diabetes
Authors: Emilie Palisaitis, Anas El Fathi, Julia E. von Oettingen, Ahmad Haidar, Laurent Legault
Journal: Diabetes Care (2020)

OBJECTIVE We developed a meal detection algorithm for the artificial pancreas (AP+MDA) that detects unannounced meals and delivers automatic insulin boluses. RESEARCH DESIGN AND METHODS We conducted a randomized crossover trial in 11 adolescents aged 12–18 years with HbA1c ≥7.5% who missed one or more boluses in the past 6 months. We compared 1) continuous subcutaneous insulin infusion (CSII), 2) artificial pancreas (AP), and 3) AP+MDA. Participants underwent three 9-h interventions involving breakfast with a bolus and lunch without a bolus. RESULTS In AP+MDA, the meal detection time was 40.0 (interquartile range 40.0–57.5) min. Compared with CSII, AP+MDA decreased the 4-h postlunch incremental area under the curve (iAUC) from 24.1 ± 9.5 to 15.4 ± 8.0 h ⋅ mmol/L (P = 0.03). iAUC did not differ between AP+MDA and AP (19.6 ± 10.4 h ⋅ mmol/L, P = 0.21) or between AP and CSII (P = 0.33). The AP+MDA reduced time &amp;gt;10 mmol/L (58.0 ± 26.6%) compared with CSII (79.6 ± 27.5%, P = 0.02) and AP (74.2 ± 20.6%, P = 0.047). CONCLUSIONS The AP+MDA improved glucose control after an unannounced meal.
Abstract 18787: Overexpression of TCTP/TPT1 Markedly Enhances Selective Export in Exosomes From Apoptotic Endothelial Cells, Mediating Smooth Muscle Cell Growth Dysregulation
Authors: Dhiya Hassan
Journal: Circulation (2017)

Background: Recent studies have shown that endothelial cell (EC) apoptosis is a central trigger for pulmonary arterial hypertension (PAH), resulting in the emergence of growth-dysregulated and apop...
16018 Safety, efficacy, and pharmacokinetics of crisaborole ointment, 2%, in infants aged 3 to &lt; 24 months with mild to moderate atopic dermatitis
Authors: Joel Schlessinger, Julie S. Shepard, Richard G. Gower, John C. Su, Charles Lynde, Vivek S. Purohit, Liza Takiya, John L. Werth, Chuanbo Zang, Bonnie Vlahos
Journal: Journal of the American Academy of Dermatology (2020)
18756 Skin biopsy for the diagnosis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: A report of two cases
Authors: Maria Pereira, Khanty Loyola, Gonzalo Hevia, Ximena Fajre, Diego Rocha, Pablo Brinck, Marcela Schultz
Journal: Journal of the American Academy of Dermatology (2020)
382MO The preliminary safety result of a phase II study of osimertinib in combination with platinum + pemetrexed in patients with previously untreated EGFR-mutated advanced NSCLC (NEJ032C/LOGIK1801: OPAL)
Authors: R. Morita, H. Asahina, K. Tanaka, R. Saito, S. Sugawara, R. Ko, K. Azuma, S. Morita, Y. Saijo, M. Maemondo, M. Seike, O. Isamu, K. Sugio, K. Kobayashi
Journal: Annals of Oncology (2020)
17752 Effects of ruxolitinib cream on affected body areas in patients with vitiligo: Subgroup analysis from a 52-week, randomized, double-blind trial
Authors: Pearl Grimes, David Rosmarin, Iltefat Hamzavi, John E. Harris, Mark Lebwohl, Alice B. Gottlieb, Kathleen A. Butler, Fiona I. Kuo, Kang Sun, Amit Pandya
Journal: Journal of the American Academy of Dermatology (2020)
Abstract IA05: Viral Mimicry in Pancreatic Cancer
Authors: Elisa Espinet, Andreas Trumpp
Journal: Cancer Research (2020)

Abstract With an overall survival rate of about 8% after five years, ductal adenocarcinoma of the pancreas (PDAC) is one of the cancers with the worst prognosis (Cancer Research UK and American Cancer Society). A hallmark of PDAC is the immense contribution of desmoplastic stroma to the total tumour mass. Typically, epithelial PDAC cells represent only a minority of cells within the tumour (as low as 10%). The excessive stromal presence represents a major technical challenge when aiming to interrogate the specific molecular signals contributed by the neoplastic epithelial cell compartment from data generated using bulk tumour samples. To address this, we FACS-purified epithelial cells from PDAC and, as controls, healthy human pancreas and performed genome-wide transcriptome and DNA methylome analyses. Clustering based on DNA methylation revealed two distinct groups of PDAC with different methylation levels at genomic regions encoding repeat elements. Methylationlow tumours showed higher expression of endogenous retroviral (ERV) transcripts and a strong engagement of the dsRNA sensing machinery. This results in the cell intrinsic activation of an interferon response signature (IFNsign), leading to the reprogramming of stromal cells towards a pro-tumourigenic microenvironment and poor patient outcome. Methylationlow/IFNsignhigh and Methylationhigh/IFNsignlow PDAC cells harboured distinct lineage traits specific for normal ductal or acinar pancreatic epithelial cells at the methylation and transcriptional level. Moreover, ductal-cell-derived KrasG12D/Trp53-/- mutant mouse PDACs showed higher expression of IFNsign compared to tumors initiated by the same genetic drivers in acinar cells. Collectively, our data point to two distinct origins and etiology of human PDACs, with the aggressive Methylationhigh/IFNsignlow tumour subtype potentially targetable by agents blocking cell intrinsic IFN-signaling. Citation Format: Elisa Espinet, Andreas Trumpp. Viral Mimicry in Pancreatic Cancer [abstract]. In: Abstracts: AACR Special Virtual Conference on Epigenetics and Metabolism; October 15-16, 2020; 2020 Oct 15-16. Philadelphia (PA): AACR; Cancer Res 2020;80(23 Suppl):Abstract nr IA05.
212P Stage I non-seminoma testicular cancer: Adjuvant management and outcomes
Authors: G.T. Quah, D. Espinoza, M. Arasaratnam, M. Crumbaker, B. Balakrishnar, A. Brooks, H. Lau, M. Patel, S. Bariol, H. Gurney
Journal: Annals of Oncology (2020)
Hepatitis C: milestones from discovery to clinical cure
Authors: Wei Hu, Chao Zhang, Ji-Jing Shi, Ji-Yuan Zhang, Fu-Sheng Wang
Journal: Military Medical Research (2020)

Abstract On October 5th, 2020, Drs. Harvey J. Alter, Michael Houghton and Charles M. Rice were rewarded with Nobel Prize in Physiology or Medicine for “the discovery of hepatitis C virus (HCV)”. During the past 50 years, remarkable achievements have been made in treatment of HCV infection: it has changed from being a life-threatening chronic disease to being curable. In this commentary, we briefly summarized the milestone events in the “scientific journey” from the first report of non-A, non-B hepatitis and discovery of the pathogen (HCV) to final identification of efficacious direct-acting antivirals. Further, we address the challenges and unmet issues in this field.
What Makes Platelets Angry: Diabetes, Fibrinogen, Obesity, and Impaired Response to Antiplatelet Therapy?⁎⁎Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Authors: Deepak L. Bhatt
Journal: Journal of the American College of Cardiology (2008)
16058 Predictors of satisfaction among patients with psoriatic disease: An analysis and visualization of the 2016 and 2017 National Psoriasis Foundation Annual Survey
Authors: Clinton Enos, Arjun Dev Saini, Hadiza Galadima, Stacie Bell, Michael Siegel, Abby S. van Voorhees
Journal: Journal of the American Academy of Dermatology (2020)
The Cardiorenal Syndrome: Do We Need a Change of Strategy or a Change of Tactics?⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Authors: Mariell Jessup, Maria Rosa Costanzo
Journal: Journal of the American College of Cardiology (2009)
17043 Frontal fibrosing alopecia severity score: A 3-year prospective study
Authors: David Saceda-Corralo, Cristina Pindado-Ortega, Diego Fernandez-Nieto, Juan Jimenez-Cauhe, Daniel Ortega-Quijano, Rita Rodrigues-Barata, Óscar M. Moreno-Arrones, Sergio Vaño-Galvan
Journal: Journal of the American Academy of Dermatology (2020)
15964 Randomized, double-blind, placebo-controlled, multiple-dose, phase 2b study to demonstrate the safety and efficacy of tildrakizumab, a high-affinity anti–interleukin-23p19 monoclonal antibody, in patients with active psoriatic arthritis
Authors: Philip J. Mease, Saima Chohan, Ferran J. García Fructuoso, Alice B. Gottlieb, Richard Chou, Alan M. Mendelsohn, Rocco Ballerini, Michael Luggen
Journal: Journal of the American Academy of Dermatology (2020)
Antibody Peptides as Cancer Vaccine—Turning Weapons to Targets
Authors: Martina Seiffert
Journal: Clinical Cancer Research (2020)

Stereotyped B-cell receptors (BCR) are frequent in patients with chronic lymphocytic leukemia (CLL). In cell culture and in mouse models of CLL, immunogenic epitopes of these BCRs were shown to trigger specific T-cell responses and to control leukemia development. These results suggest vaccination with autologous BCR-derived peptides as a novel therapy for CLL.See related article by Rovida et al., p. 729.
Ketamine‐Induced Sclerosing Cholangitis (KISC) in a Critically Ill Patient With COVID‐19
Authors: Sally A.I. Knooihuizen, Ariel Aday, William M. Lee
Journal: Hepatology (2020)

1Division of Digestive and Liver DiseasesUT Southwestern Medical Center at DallasDallasTX 2Parkland Health and Hospital SystemDallasTX *ADDRESS CORRESPONDENCE AND REPRINT REQUESTS TO: Sally A.I. Knooihuizen, M.D. Division of Digestive and Liver Diseases, 5959 Harry Hines Blvd. HP05.520 Dallas, TX 75390‐8887 E‐mail: [email protected] Tel.: +1‐214‐645‐0595
Association of Frailty With Morbidity and Mortality in Emergency General Surgery By Procedural Risk Level
Authors: Manuel Castillo-Angeles, Zara Cooper, Molly P. Jarman, Daniel Sturgeon, Ali Salim, Joaquim M. Havens
Journal: JAMA Surgery (2020)

<h3>Importance</h3> In this aging society, older patients are more commonly undergoing emergency general surgery (EGS). Although frailty has been associated with worse outcomes in this population, EGS encompasses a heterogeneous mix of procedures. <h3>Objective</h3> To determine if the association of frailty with morbidity and mortality in EGS patients varies based on the level of procedural risk. <h3>Design, Setting, and Participants</h3> This cross-sectional study analyzed Medicare inpatient claims file (January 2007-December 2015) and included all inpatients who underwent 1 of 7 previously described EGS procedures shown to represent 80% of EGS volume, complications, and mortality nationally. Analysis took place from September 2019 to January 2020. <h3>Exposures</h3> The primary exposure of interest was risk procedural level. EGS procedures were stratified as high risk (excision of small intestine, excision of large intestine, peptic ulcer repair, lysis of peritoneal adhesions, and laparotomy) and low risk (appendectomy and cholecystectomy). <h3>Main Outcomes and Measures</h3> The primary outcome was overall 30-day mortality after discharge. Frailty was assessed using a claims-based frailty index. Multivariate logistic regression analysis was used and was stratified by risk level. <h3>Results</h3> A total of 882 929 EGS patients were included in this study (mean [SD] age, 77.9 [7.5] years; 483 637 [54%] were female). Overall mortality was 4.5% (n = 40 304). The frailty index classified 12.6% (n = 111 513) of patients as frail, and mortality within this group was 9.9% (n = 11 307). High-risk procedures represented 53% (n = 468 098) of the caseload, and mortality was 6.8% (n = 31 979). For low-risk procedures, mortality was 2% (n = 8325). Frailty was significantly associated with mortality (odds ratio, 1.64; 95% CI, 1.60-1.68). After stratified analysis, this association remained significant for high-risk (odds ratio, 1.53; 95% CI, 1.49-1.58) and low-risk (odds ratio, 2.05; 95% CI, 1.94-2.17) procedures. <h3>Conclusions and Relevance</h3> Frailty was significantly associated with mortality in patients undergoing EGS, with an even greater association in low-risk procedures. Preoperative frailty assessment is imperative even in low-risk procedures.
Abstract S07-02: Patient-reported outcomes of breast cancer patients during the COVID-19 outbreak in the epicenter of China: A cross-sectional survey study
Authors: Juanjuan Li, Cesar Augusto Santa-Maria, Hongfang Feng, Lingcheng Wang, Pengcheng Zhang, Yuangbing Xu, Yuyan Tan, Zhongchun Liu, Bo Du, Meng Lan, Qingfeng Yang, Feng Yao, Yi Tu, Shengrong Sun, Xingrui Li, Chuang Chen
Journal: Clinical Cancer Research (2020)

Abstract Purpose: We aimed to analyze the psychological status of breast cancer (BC) patients in the epicenter of the COVID-19 pandemic. Patients and Methods: A total of 658 individuals were recruited from multiple breast cancer centers in Hubei Province. Online questionnaires were conducted and included demographic information, clinical features, and four patient-reported outcomes (PROs) scales (GAP-7, PHQ-9, ISI, and IES-R). Multivariable logistic regression analysis was designed to identify potential factors on mental health outcomes. Results: Questionnaires were collected from February 16 to 19, 2020, the peak time point of COVID-19 outbreak in China. 46.2% of BC patients had to modify planned necessary anticancer treatment during the outbreak. 8.9% and 9.3% of patients reported severe anxiety and severe depression, respectively. 20.8% and 4.0% of patients showed severe distress and insomnia, respectively. Multivariable logistic regression analysis demonstrated poor general condition, shorter duration after BC diagnosis, aggressive BC molecular subtypes, and close contact with COVID-19 patients as independent factors associated with anxiety. Poor general condition and CVC (central venous catheter) flushing delay were factors independently associated with depression. In terms of insomnia, poor general condition was the only associated independent factor. Poor physical condition and treatment discontinuation were underlying risk factors for distress based on multivariable analysis. Conclusion: High rates of anxiety, depression, distress, and insomnia were observed in patients with breast cancer during the COVID-19 outbreak. Special attention should be paid to the psychological status of breast cancer patients, especially those with poor general condition, treatment discontinuation, aggressive molecular subtypes, and metastatic breast cancer. Citation Format: Juanjuan Li, Cesar Augusto Santa-Maria, Hongfang Feng, Lingcheng Wang, Pengcheng Zhang, Yuangbing Xu, Yuyan Tan, Zhongchun Liu, Bo Du, Meng Lan, Qingfeng Yang, Feng Yao, Yi Tu, Shengrong Sun, Xingrui Li, Chuang Chen. Patient-reported outcomes of breast cancer patients during the COVID-19 outbreak in the epicenter of China: A cross-sectional survey study [abstract]. In: Proceedings of the AACR Virtual Meeting: COVID-19 and Cancer; 2020 Jul 20-22. Philadelphia (PA): AACR; Clin Cancer Res 2020;26(18_Suppl):Abstract nr S07-02.
16799 Similar efficacy of maintenance treatment of finasteride 1 mg every other month compared with finasteride 1 mg daily in Korean men with androgenetic alopecia after taking finasteride 1 mg daily for 1 year
Authors: Ki-Hun Kim, Sang-Myung Park, Ye Jin Lee, Woo-Young Sim, Bark-Lynn Lew
Journal: Journal of the American Academy of Dermatology (2020)
142P Prognostic analysis of patients with intra-abdominal infectious complications after laparoscopy and open radical gastrectomy for gastric cancer: A propensity score-matching analysis
Authors: S-J. Que, W-W. Qiu, Q. Zhong, Q-Y. Chen, C-H. Zheng, P. Li, J-W. Xie, J-B. Wang, J-X. Lin, J. Lu, L-L. Cao, M. Lin, R-H. Tu, Z-N. Huang, J-L. Lin, H-L. Zheng, C. Huang
Journal: Annals of Oncology (2020)
Abstract 17052: Concomitant Overexpression of Sod1, Sod3, and Gshpx-1 Improves Recovery of the Ischemic Limb in Mice Independent of Endothelial Progenitor Cell Mobilization
Authors: Lingjuan Liu, Yuqi Cui, Xiaoyun Xie, Hua Zhu, Hong Hao, Peter J Cowan, Richard J Gumina, Chandan K Sen, Zhenguo Liu
Journal: Circulation (2013)

Oxidative stress plays an important role in ischemic injury. Limb ischemia is a potent stimulator for endothelial progenitor cell (EPC) mobilization. The present study was to determine if concomita...
13843 Baseline burden of disease in patients with mild to moderate versus severe psoriasis: Insights from LAPIS-PSO reflecting routine dermatology care in germany
Authors: Kristian Reich, Stefanie Fritzlar, Bernhard Korge, Uwe Schwichtenberg, Stephan Morys, Katrin Lorenz-Baath, Josefine Roemmler-Zehrer, Natalie Núnez Gómez
Journal: Journal of the American Academy of Dermatology (2020)
Levels of domain-specific physical activity at work, in the household, for travel and for leisure among 327 789 adults from 104 countries
Authors: Tessa Strain, Katrien Wijndaele, Leandro Garcia, Melanie Cowan, Regina Guthold, Soren Brage, Fiona C Bull
Journal: British Journal of Sports Medicine (2020)

Objective To compare the country-level absolute and relative contributions of physical activity at work and in the household, for travel, and during leisure-time to total moderate-to-vigorous physical activity (MVPA). Methods We used data collected between 2002 and 2019 from 327 789 participants across 104 countries and territories (n=24 low, n=34 lower-middle, n=30 upper-middle, n=16 high-income) from all six World Health Organization (WHO) regions. We calculated mean min/week of work/household, travel and leisure MVPA and compared their relative contributions to total MVPA using Global Physical Activity Questionnaire data. We compared patterns by country, sex and age group (25–44 and 45–64 years). Results Mean MVPA in work/household, travel and leisure domains across the 104 countries was 950 (IQR 618–1198), 327 (190–405) and 104 (51–131) min/week, respectively. Corresponding relative contributions to total MVPA were 52% (IQR 44%–63%), 36% (25%–45%) and 12% (4%–15%), respectively. Work/household was the highest contributor in 80 countries; travel in 23; leisure in just one. In both absolute and relative terms, low-income countries tended to show higher work/household (1233 min/week, 57%) and lower leisure MVPA levels (72 min/week, 4%). Travel MVPA duration was higher in low-income countries but there was no obvious pattern in the relative contributions. Women tended to have relatively less work/household and more travel MVPA; age groups were generally similar. Conclusion In the largest domain-specific physical activity study to date, we found considerable country-level variation in how MVPA is accumulated. Such information is essential to inform national and global policy and future investments to provide opportunities to be active, accounting for country context.