tbuckley/cabot-search huggingface dataset:
Helicobacter pylori in gastro-oesophageal reflux disease needs comparator
Journal: BMJ (2003)

composition, ranging from lone consultant nurses to multiprofessional teams, and in their working patterns and activity. 9Some outreach teams follow up patients as described in our study, whereas others attend once patients show early warning criteria (see box).The results of our study are therefore not transferable. LimitationsOur study design could have confounded the results; before and after studies are retrospective, therefore variables cannot be controlled.In our study a concomitant innovation in the hospital could have produced the same results.Patients were, however, discharged from critical care to different areas of the hospital, and at the time of the study there was no other innovation that could have had an effect on patients.The median predicted probability of mortality was 16.1% compared with 20.4% in the historical cohort.Although this was not statistically significant, part or all of the effect seen might be explained by this difference.Several authors have, however, questioned the ability of the tool to predict mortality and it is currently the subject of further investigation by the Intensive Care National Audit Research Centre.The tool therefore might explain some of the variation in outcome but not all of it.Before and after studies may also show a lack of equivalence between comparators, and interventions may vary.Both our groups had similar risk factors.These were chosen for their association with mortality and readmission and seemed to be appropriate for the purposes of our study.The interventions undertaken by team members did vary, possibly owing to length of time available for the intervention or the manner in which the intervention was undertaken by the individual and on a particular day.It is unlikely, however, that one individual or one intervention can be associated with the findings.Rather, the combined effect of the interventions seems to have had a beneficial effect on outcomes.The use of routine audit data, rather than specific data collected for research purposes, may also have produced erroneous results.The database was examined on a random basis for reliability and seemed sound.If the innovation described here had not been introduced so hastily, owing to political imperative, we could have conducted a prospective randomised controlled trial.Evidence for innovation in service delivery will always be prone to limitations where evaluation is not undertaken before wholesale application.Policy makers should consider testing health service innovation using cluster randomised controlled trials with the hospital as the sampling unit.An example of this is the medical early response intervention and therapy study currently being undertaken in Australia to assess medical emergency teams. 10
Abstract P237: Sex and Body-mass Index Specific Percentiles for Neck and Waist Circumference in the Longitudinal Study of Adult Health: ELSA Brasil
Authors: Cristina P Baena, Bruno Moura, Alessandra Goulart, Paulo Lotufo, Itamar Santos, Isabela Benseñor
Journal: Circulation (2017)

Background: Waist circumference (WC) and neck circumference (NC) have been linked with higher cardiovascular risk, which cannot be explained only by the association with higher BMI. Therefore, the distributions of predicted neck circumference and waist circumference values according to BMI may be a useful measurement of fat distribution. Aim: To describe percentiles for WC and NC according to BMI and stratified by sex in a large non-clinical based sample of middle-aged Brazilians. Methods: From the 15105 participants from ELSA-Brasil, 15085 partcipants with complete data were included in this analysis. Height and weight were measured using a standardized scale, and BMI was calculated by dividing body weight with the squared height in meters (kg/m2). Waist circumference (cm) was measured using standardized procedures and equipment. Neck circumference was measured with an inelastic tape (mm) immediately above the cricoid cartilage and perpendicular to the long axis of the neck, with the participant in a sitting position. We determined the estimated distribution function in men and women, with special interest in the 25 th , 50 th , 75 th and 90 th percentiles for neck and waist circumferences in ELSA-Brasil baseline fitting spline quantile regression models. Sex-specific nomograms were also built. Analyses were performed using R software and SPSS analytical package. Results: We evaluated 6880 men (52.2 ± 9.3 years old) and 8205 women (52.0 ± 8.9 years old). Among men, mean WC, NC and BMI were 95.3 ± 11.7 cm, 39.5 ±2.9 cm and 27.0 ± 4.3 kg/m2, respectively. Among women mean WC, NC and BMI were 87.8 ± 12.6 cm, 34.0 ±2.6 cm and 27.0 ± 5.1kg/m2, respectively. Table 1 shows respective 25 th , 50 th , 75 th and 90 th percentiles with correspondent 95% prediction interval in cm for NC and WC by BMI and sex. Conclusion: In this study, we describe sex-specific centile values for NC and WC according to BMI. This distribution may be useful in the study of body fat distribution as a marker of cardiovascular risk beyond BMI values.
POST-ALCOHOLISM.
Authors: S. V. CLEVENGER
Journal: JAMA (1895)

Ethyl alcohol, spirit of wine, is commercially assumed to be the base of intoxicating drinks, and the purest of these is capable of working great havoc when abused, but the demand for cheap liquor in vast quantities substitutes for portions of the less harmful ethyl or vinic alcohol what is known to chemists as the poisonous amyl alcohol (potato spirit or fusel oil). The aroma or bouquet of liquors is largely due to certain ethers of the more poisonous amyl and butyl alcohols, notably the acetic and valeric; then super-added, all too often, by distiller, rectifier, wholesaler, and especially by the retailer, are sophistications, flavors and perfumes for the purpose of cheapening the resulting compound, which, by the time it reaches the average consumer, contains in addition to the alcohol diluents to increase bulk, articles to give it false strength, fictitious appearance, odor and taste. In the English Licensing Act
Critical care of patients with AIDS
Authors: R. M. Wachter
Journal: JAMA (1992)

<h3>Objective.</h3> —We sought to review the clinical and ethical issues surrounding critical care for patients with the acquired immunodeficiency syndrome (AIDS). <h3>Data Sources.</h3> —We reviewed published studies and abstracts dealing with the outcome of critical care for patients with AIDS, decision making about life-sustaining treatments in patients with AIDS, and infection control in the intensive care unit. We also consulted with a number of experts in the field. <h3>Study Selection.</h3> —We selected outcome studies in which patients with documented AIDS or infection with the human immunodeficiency virus (HIV) were analyzed. We rejected data concerning patients with suspected or presumed AIDS and data concerning presumed cases of<i>Pneumocystis carinii</i>pneumonia (PCP). <h3>Data Synthesis.</h3> —Most AIDS patients who require critical care do so because of respiratory failure caused by PCP. Although studies early in the epidemic reported survival rates to hospital discharge of 0% to 14%, recent studies demonstrate improved survival rates of 36% to 55%. Treatment for patients with PCP and respiratory failure should include either intravenous trimethoprim-sulfamethoxazole or pentamidine isethionate, as well as adjuvant corticosteroids. Patients with AIDS may require critical care for many other indications, including seizures, sepsis, and hypotension, or reasons unrelated to their immunodeficiency. In general, such patients have a better prognosis than those with respiratory failure. <h3>Conclusions.</h3> —The provision of critical care for PCP and respiratory failure specifically or AIDS generally cannot be considered futile. Therefore, decisions about the use of critical care should be guided by the particular clinical situation and the patient's preferences. More research is needed to elucidate the reasons for the improving survival for patients with PCP and respiratory failure and the predictors of such survival. (<i>JAMA</i>. 1992;267:541-547)
Medical Education, Registration and Hospital Service
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Measuring diaphragm thickness with ultrasound in mechanically ventilated patients: feasibility, reproducibility and validity
Authors: Ewan C. Goligher, Franco Laghi, Michael E. Detsky, Paulina Farias, Alistair Murray, Deborah Brace, Laurent J. Brochard, Steffen Sebastien-Bolz, Gordon D. Rubenfeld, Brian P. Kavanagh, Niall D. Ferguson
Journal: Intensive Care Medicine (2015)
Abstract 4333: GCN5 positively correlates with c-MYC in non-small cell lung cancer
Authors: Lisa Maria Mustachio, Jason Roszik, Aimee Farria, Sharon YR Dent
Journal: Cancer Research (2019)

Abstract Lung cancer causes the highest mortality in cancer-related deaths. Definition of novel molecular targets is needed since these cancers often become resistant to existing therapies. Epigenetic modifications may provide such targets. Recent reports suggest that the histone acetyltransferase (HAT) module within the transcriptional coactivator SAGA complex plays a role in cancer, creating a new link between epigenetic regulators and this disease. We aim to define the role of the SAGA HAT protein GCN5 in the regulation and function of oncogenes in lung cancers. Since prior work indicates that GCN5 regulates the stability of c-MYC and serves as a coactivator for MYC target genes, we hypothesize that there is a positive relationship between GCN5 and c-MYC in non-small cell lung cancer (NSCLC). We also propose that inhibition of GCN5 will reduce lung cancer formation and progression in mouse models of lung cancer driven by c-MYC overexpression. Our data indicate that both GCN5 and c-MYC proteins are upregulated in NSCLC cells compared to normal lung epithelial cell lines. This trend is observable only at the protein level, indicating that the upregulation of these proteins in NSCLC cells occurs post-transcriptionally. Both GCN5 and c-MYC expression levels are also positively associated in mouse and human NSCLC cell lines. Genetic repression of GCN5 in NSCLC cells reduces cell proliferation, increases the population of necrotic cells, and reduces c-MYC expression. Inhibition of the GCN5 active site using commercially available probes in NSCLC cells significantly (p &amp;lt; 0.05) reduces cell proliferation, increases the percentage of cells undergoing apoptosis, and reduces c-MYC expression. In human NSCLC tissues, GCN5 and c-MYC positively correlate and are associated with MYC target genes. Our ongoing studies will determine whether targeting GCN5 represses multiple oncogenic pathways in cancer and whether it inhibits oncoproteins difficult to directly target, such as MYC. We expect that our findings will highlight the importance of epigenetic regulators in carcinogenesis and extend beyond our current research focus to other cancer types. Citation Format: Lisa Maria Mustachio, Jason Roszik, Aimee Farria, Sharon YR Dent. GCN5 positively correlates with c-MYC in non-small cell lung cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4333.
Psychogenese und Psychotherapie körperlicher Symptome.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Trial-Based Cost-Effectiveness Analyses of Antipsychotic Use
Authors: Daniel Polsky, Jalpa A. Doshi, Mark S. Bauer, Henry A. Glick
Journal: American Journal of Psychiatry (2006)

Objective: Second-generation antipsychotics make up one of the fastest growing segments of the rapidly growing pharmaceutical sector. Given limited health care resources, assessment of the value for the cost of second-generation antipsychotics relative to first-generation antipsychotics is critical for resource-allocation decisions. Method: With a MEDLINE search, the authors identified eight studies (based on six randomized clinical trials) that analyzed the cost-effectiveness of second-generation antipsychotics relative to first-generation antipsychotics in individuals with schizophrenia disorders. The authors reviewed appropriate methods of measurement, analysis, and design of cost-effectiveness studies in randomized clinical trials and evaluated the validity of economic results derived from the studies in light of appropriate methods. Results: The eight randomized clinical trial-based cost-effectiveness studies of antipsychotic medications faced a variety of threats to validity related to 1) measurement of costs, 2) measurement of effectiveness, 3) analysis of costs, 4) measurement of sampling uncertainty, 5) analysis of incomplete cost data, 6) minimizing loss to follow-up, and 7) threats to external validity. Conclusions: Economic claims made by the authors of a number of trial-based economic evaluations have generally been favorable to second-generation antipsychotics. However, the methodological issues the authors of the current study identified suggest that there is no clear evidence that atypical antipsychotics generate cost savings or are cost-effective in general use among all schizophrenia patients. Psychiatrists, researchers, and administrators should consider the methodological issues highlighted in interpreting study results. These issues should be addressed in future trial designs.
Erratum: The gene mutated in juvenile nephronophthisis type 4 encodes a novel protein that interacts with nephrocystin
Authors: G Mollet, R Salomon, O Gribouval, F Silbermann, D Bacq, G Landthaler, D Milford, A Nayir, G Rizzoni, C Antignac, S Saunier
Journal: Nature Genetics (2002)
Book Reviews
Authors: Nicoletta Sonino, C.M. van der Feltz-Cornelis, R. van Dyck, Marie-Anne Haenen, Anton J.M. Schmidt, Mieke Schoenmakers, Marcel A. van den Hout, Melissa Farley, Howard Barkan, Klaus Portmann, Bogdan P. Radanov, Lawrence A. Labbate, Michael E. Doyle, Vanja Blomkvist, Jan Hannerz, Kristina Orth-Gomér, Töres Theorell, Bengt B. Arnetz, Annie Laurent, Jacques Boucharlat, Jean-Luc Bosson, Andrew Derry, Roger Imbert
Journal: Psychotherapy and Psychosomatics (1997)
A 61-Year-Old Man With Parkinson's Disease, 1 Year Later-Reply
Authors: C Thomas L. Delbanco
Journal: JAMA (1997)

<h3>In Reply.</h3> —As the patient's primary physician, I agree with Dr Enker's important comments regarding the devastating effects Parkinson disease can have on patients and their families. Perhaps it would be most helpful to present some further information about the patient discussed in the Clinical Crossroads articles.<sup>1,2</sup>After he gave up his dental practice, faced with loss of esteem and with new financial burdens, Dr H became clinically depressed. He was treated with counseling and medication by a psychiatrist, in collaboration with his consulting neurologist and me. He received important social service support and had the good fortune to have a remarkably supportive and loving family. The therapy proved helpful and he gradually improved. This man of healing felt a need to continue on in his life as a healer and began volunteering in a local hospice. His participation in the Clinical Crossroads conference was a source of great pride to
Medical News
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Association News.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Cover
Authors: Charlene Breedlove
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Index to advertisers
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Software
Authors: Lewis C. Rose
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal