tbuckley/cabot-search huggingface dataset:
Synergistic osteogenic and angiogenic effects of KP and QK peptides incorporated with an injectable and self-healing hydrogel for efficient bone regeneration
Authors: Runze Li, Chen Zhou, Jun Chen, Haotian Luo, Ruoyu Li, Danying Chen, Xuenong Zou, Weicai Wang
Journal: Bioactive Materials (2022)

Irregular defects generated by trauma or surgery in orthopaedics practice were usually difficult to be fitted by the preformed traditional bone graft substitute. Therefore, the injectable hydrogels have attracted an increasing interest for bone repair because of their fittability and mini-invasivity. However, the uncontrollable spreading or mechanical failures during its manipulation remain a problem to be solved. Moreover, in order to achieve vascularized bone regeneration, alternatives of osteogenic and angiogenic growth factors should be adopted to avoid the problem of immunogenicity and high cost. In this study, a novel injectable self-healing hydrogel system (GMO hydrogel) loaded with KP and QK peptides had been developed for enhancing vascularized regeneration of small irregular bone defect. The dynamic imine bonds between gelatin methacryloyl and oxidized dextran provided the GMO hydrogel with self-healing and shear-thinning abilities, which led to an excellent injectability and fittability. By photopolymerization of the enclosed GelMA, GMO hydrogel was further strengthened and thus more suitable for bone regeneration. Besides, the osteogenic peptide KP and angiogenic peptide QK were tethered to GMO hydrogel by Schiff base reaction, leading to desired releasing profiles.
BOOK REVIEWS
Authors: A. HOUGHTON
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article BOOK REVIEWS Get access Basic and Clinical Aspects of Malignant Melanoma. L. Nathanson ed. Dordrecht, The Netherlands: Nijhoff, 1987, 222 pp. $72.50. ALAN HOUGHTON ALAN HOUGHTON Memorial Sloan-Kettering Institute1275 New York Ave. New York, NY 10021 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 5, 4 May 1988, Page 375, https://doi.org/10.1093/jnci/80.5.375 Published: 04 May 1988
The Biology of the Immune Response
Authors: Henry N. Claman
Journal: JAMA (1987)

<h3>CHARACTERISTICS OF THE IMMUNE SYSTEM</h3> THE IMMUNE system is composed of a large and complex set of elements that are widely distributed. It seems to be designed to protect against foreign pathogens while not responding adversely to self-components. Thus, it must distinguish "self" from "not self." This distinction is made by an elaborate, specific-recognition system that, ultimately, inheres in T and B lymphocytes —the only immunologically specific components of the immune mechanism. The immune system also has nonspecific effector mechanisms that (usually) amplify the specific functions. These nonspecific features include mononuclear phagocytes, polymorphonuclear leukocytes, and the complement system. The immune system has several interesting characteristics. <h3>Specificity</h3> Immune reactions distinguish between non—cross-reacting antigens. Specificity is mediated through the antigen-specific receptors on the surfaces of T and B lymphocytes and through antibodies. <h3>Memory</h3> The immunologic response to an antigenic stimulus usually leaves the immune system changed. Ordinarily, a second administration of antigen
COMMENTS ON CANCER
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"LOCAL ANESTHESIA IN OPERATIONS FOR MASTOIDITIS"
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clearing Your Mind: Mechanisms of Debris Clearance After Cell Death During Neural Development
Authors: Kendra E. Liu, Michael H. Raymond, Kodi S. Ravichandran, Sarah Kucenas
Journal: Annual Review of Neuroscience (2022)

Neurodevelopment and efferocytosis have fascinated scientists for decades. How an organism builds a nervous system that is precisely tuned for efficient behaviors and survival and how it simultaneously manages constant somatic cell turnover are complex questions that have resulted in distinct fields of study. Although neurodevelopment requires the overproduction of cells that are subsequently pruned back, very few studies marry these fields to elucidate the cellular and molecular mechanisms that drive nervous system development through the lens of cell clearance. In this review, we discuss these fields to highlight exciting areas of future synergy. We first review neurodevelopment from the perspective of overproduction and subsequent refinement and then discuss who clears this developmental debris and the mechanisms that control these events. We then end with how a more deliberate merger ofneurodevelopment and efferocytosis could reframe our understanding of homeostasis and disease and discuss areas of future study.
Medical News
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Union Médicale du Canada, Montreal
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Desmoid tumor presenting as a parotid mass
Authors: B. Majmudar
Journal: JAMA (1978)

THE DESMOID tumor is an aggressively proliferating, musculoaponeurotic tumor commonly arising from the abdominal musculature. Infrequently, it may arise from other locations such as the shoulder girdle<sup>1</sup>or pelvic musculature.<sup>2</sup>The rarity of this lesion in the parotid area prompted us to report this case. <h3>Report of a Case</h3> A 26-year-old woman was admitted to Grady Memorial Hospital complaining of a mass behind her right jaw bone. She had noticed this mass six months prior to admission and it had been enlarging progressively since then. Significant past history included extraction of carious teeth six years previously and childhood illnesses such as mumps, measles, and chickenpox. Her last pregnancy had been eight years prior to admission. She had no history of nor was she presently taking any medications including methysergide maleate. Physical examination results showed a 6×4-cm hard, slightly tender mass in the right parotid area extending below the
MRI of the breast before and after primary systemic therapy correlates with histopathological outcome in patients with locally advanced breast cancer (LABC)
Authors: V. I. Russu, B. Lex, T. Gilster, K. Pfaffenberger, H. Volkholz, A. Groβmann, A. H. Tulusan
Journal: Journal of Clinical Oncology (2004)

9704 Background: Primary systemic therapy (PST) is a widely accepted preoperative treatment for patients with LABC. Already established methods for measuring the size of lesions and monitoring the tumor-response to chemotherapy are clinical palpation, mammography and ultrasound, but specificity of these methods is unsatisfactory. MRI seems to be a very sensitive method to detection of breast cancer. The aim of this study was to clarify the accuracy of MRI in monitoring the tumor-response to PST. Methods: 57 female patients (range of age: 29a-68a) with LABC (cT2 -cT4) were examined with dynamic contrast enhanced MRI before and after PST. 24 patients were treated with sequential anthracyclin and taxan based chemotherapy and 33 with only anthracyclin based chemotherapy. 53% patients were premenopausal. 63% had an ER-positive tumor. The measure of tumor-response to PST was graded in partial response (PR: > 50% of tumor reduction mm2), no change (NC: < 50%) and complete response (CR: no evidence of residual tumor-cells) Results: Comparing tumor-size measured by MRI before and after PST 50% of the patients had PR and 14% CR. NC had 36%. The histological tumor-size after PST strongly correlated with the size measured by MRI r = 0,849(p<0,001). With MRI all 4 cases of pCR were detected. The overall accuracy of MRI was 93%. The sensitivity of MRI in detection of pCR after PST in our study was 100% and specificity 94%. False positive rate was 15%. Conclusions: MRI could become a standard method to monitore the tumor-response to chemotherapy. MRI seems to be very sensitive in detection of pCR, but high false positive rate makes it not useful for prediction of pCR. Further studies could find out if MRI is a suitable tool to determine the length of PST or to show the necessity to change the regiment in chemotherapy-resistant tumors. No significant financial relationships to disclose.
Guy's Hospital Reports. Third series, Vol. xxxii.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Optimized Surveillance Intervals Following Endoscopic Eradication of Dysplastic Barrett’s Esophagus: An International Cohort Study
Authors: Allon Kahn, Julia Crook, Michael G Heckman, Mikolaj A Wieczorek, Sarmed Sami, Diana Snyder, Siddharth Agarwal, Jose Santiago, Jacobo Ortiz Fernandez-Sordo, W Keith Tan, Ramona Lansing, Kenneth K Wang, Krish Ragunath, Massimiliano DiPietro, Herbert Wolfsen, Francisco Ramirez, David Fleischer, Cadman L Leggett, Prasad G Iyer
Journal: Clinical Gastroenterology and Hepatology (2022)
The Morphologic Aspect of Intelligence.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparative Effectiveness of Surveillance Colonoscopy Intervals on Colorectal Cancer Outcomes in a National Cohort of Patients with Inflammatory Bowel Disease
Authors: Hyun-seok Kim, Ruben Hernaez, Shubhada Sansgiry, Akbar K. Waljee, Frank I. Scott, James D. Lewis, Hashem B. El-Serag, Jason K. Hou
Journal: Clinical Gastroenterology and Hepatology (2022)
The NCCLS and medical devices
Authors: R. J. Jones
Journal: JAMA (1980)

Few practicing physicians are aware of the activities of the National Committee for Clinical Laboratory Standards (NCCLS), which was founded in 1968 when it grew out of a committee of the College of American Pathologists (CAP) as an interdisciplinary nonprofit organization. It provides a forum in the private sector that promotes the development and use of standards for the clinical laboratory. More than 120 member organizations from the United States and a few foreign countries contribute support in organizational dues and in providing representation on a myriad of committees, subcommittees, and task forces, each of which attempts to develop a consensus statement outlining standards for a selected procedure, its reagents, indications, interpretations, and limitations. The initial proposed standard is circulated to all parties thought to be interested for commentary. After one year it is reconsidered and, after revision, is then considered an approved standard. The latter is reviewed, and revision
A case of massive bleeding after endoscopic sphincterotomy in a patient with a history of large walled-off pancreatic necrosis in the area of the pancreatic groove
Authors: Shuhei Shintani, Osamu Inatomi, Yoshiya Takeda, Takehide Fujimoto, Shigeki Bamba, Hiromu Kutsumi, Akira Andoh
Journal: Endoscopy (2022)

Walled-off pancreatic necrosis (WOPN) associated with severe acute pancreatitis is sometimes fatal [1]. Interventional endoscopic ultrasonography has improved clinical outcomes; however, the long-term prognosis in such cases remains unknown [2] [3]. WOPN extending to the area of the pancreatic groove has been reported to cause structural abnormalities to the bile duct, with the presence of abnormal blood vessels [4].
Physicians' Cards.
Authors: None J. O. W.
Journal: JAMA (1896)

Anderson, S. C., Sept. 5, 1896. <h3>To the Editor:</h3> —Is it contrary to the Code of Medical Ethics or the by-laws of theAmerican Medical Associationto use on a business or visiting card the words " Diseases of Women and Children," or any other words indicating a special line of practice? If not those words, is the word " Gynecologist" admissible? For instance, " Dr. Leptandrin, Cormes, Florida, Diseases of Women and Children." Awaiting your reply, am very truly yours, <h3>Answer:</h3> The reading of the Code explicitly says: " It is derogatory to the dignity of the profession to resort to public advertisements, or<i>private cards</i>, or hand bills inviting the attention of individuals affected with particular diseases, etc." —Vide Code of Ethics, "Of the Duties of Physicians to Each Other and to the Profession at Large."—Art. 1, Sec. 4. Now this is the exact language of the Code, and is in all
Optical Projection Tomography
Authors: James Sharpe
Journal: Annual Review of Biomedical Engineering (2004)

▪ Abstract Optical projection tomography is a new approach for three-dimensional (3-D) imaging of small biological specimens. It fills an imaging gap between MRI and confocal microscopy, being most suited to specimens that are from 1 to 10 mm across. The tomographic principles of optical projection tomography (OPT) are explained, its most important applications in biomedical research explored, and comparisons drawn of its pros and cons compared to a number of alternative imaging technologies.
Current approaches of nanomedicines in the market and various stage of clinical translation
Authors: Xiaoting Shan, Xiang Gong, Jie Li, Jingyuan Wen, Yaping Li, Zhiwen Zhang
Journal: Acta Pharmaceutica Sinica B (2022)

Compared with traditional drug therapy, nanomedicines exhibit intriguing biological features to increase therapeutic efficiency, reduce toxicity and achieve targeting delivery. This review provides a snapshot of nanomedicines that have been currently launched or in the clinical trials, which manifests a diversified trend in carrier types, applied indications and mechanisms of action. From the perspective of indications, this article presents an overview of the applications of nanomedicines involving the prevention, diagnosis and treatment of various diseases, which include cancer, infections, blood disorders, cardiovascular diseases, immuno-associated diseases and nervous system diseases, etc. Moreover, the review provides some considerations and perspectives in the research and development of nanomedicines to facilitate their translations in clinic.
Targeting tumor endothelial hyperglycolysis enhances immunotherapy through remodeling tumor microenvironment
Authors: Yunlong Shan, Qi Ni, Qixiang Zhang, Mengying Zhang, Bin Wei, Lingge Cheng, Chongjin Zhong, Xinyu Wang, Qingqing Wang, Jiali Liu, Jingwei Zhang, Jingjing Wu, Guangji Wang, Fang Zhou
Journal: Acta Pharmaceutica Sinica B (2022)

Vascular abnormality is a hallmark of most solid tumors and facilitates immune evasion. Targeting the abnormal metabolism of tumor endothelial cells (TECs) may provide an opportunity to improve the outcome of immunotherapy. Here, in comparison to vascular endothelial cells from adjacent peritumoral tissues in patients with colorectal cancer (CRC), TECs presented enhanced glycolysis with higher glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression. Then an unbiased screening identified that osimertinib could modify the GAPDH and thus inhibit its activity in TECs. Low-dose osimertinib treatment caused tumor regression with vascular normalization and increased infiltration of immune effector cells in tumor, which was due to the reduced secretion of lactate from TECs by osimertinib through the inhibition of GAPDH. Moreover, osimertinib and anti-PD-1 blockade synergistically retarded tumor growth. This study provides a potential strategy to enhance immunotherapy by targeting the abnormal metabolism of TECs.
<i>Erratum</i>: Vol. 70, No. 30
Authors: Meredith Dixon, Caitlyn Lutfy
Journal: MMWR Morbidity and Mortality Weekly Report (2021)

On page 970, in Table 3, in the row for "Social participation ability," in the columns for "Post-COVID-19 patients," "Control patients," and "mean difference" the summary scale T-score mean standard deviations and mean differences should have read, "46.6 (44.7 to 48.6)," "50.5 (50.0 to 51.1)," and " -4.2 (-6.4 to -2.0)," respectively.
Re: Writing committee for the Post-Injection Endophthalmitis Study Group, et al.: The influence of universal face mask use on endophthalmitis risk after intravitreal anti-vascular endothelial growth factor injections (Ophthalmology. 2021;128:1620–1626)
Authors: Kathrine Blom, Ragnheiður Bragadóttir, Magne Sand Sivertsen, Morten Carstens Moe, Øystein Kalsnes Jørstad
Journal: Ophthalmology (2022)