tbuckley/cabot-search huggingface dataset:
Chemokine profiling in children and adults with symptomatic and asymptomatic respiratory viral infections
Authors: G. Den Hartog, T.H.A. Ederveen, P.B. Venkatasubramanian, G. Ferwerda, C.H. van den Kieboom, C.E. van der Gaast-de Jongh, M. Vissers, J. Zoll, W.J.G. Melchers, M.A. Huynen, N. Rots, J. Rahamat-Langendoen, M.I. de Jonge
Journal: Journal of Infection (2021)
Post-partum psychosis and its association with bipolar disorder in the UK: a case-control study using polygenic risk scores
Authors: Arianna Di Florio, Jessica Mei Kay Yang, Karen Crawford, Veerle Bergink, Ganna Leonenko, Antonio F Pardiñas, Valentina Escott-Price, Katherine Gordon-Smith, Michael J Owen, Nick Craddock, Lisa Jones, Michael O'Donovan, Ian Jones
Journal: The Lancet Psychiatry (2021)
TCT-3 Cardiac Neuromodulation Therapy Reduces Systolic Blood Pressure and Pulse Pressure in Patients With Isolated Systolic Hypertension in a Randomized Double-Blind Study
Authors: Daniel Burkhoff, Zbigniew Kalarus, Germanas Marinskis, Marcin Grabowski, Jaroslaw Kazmierzcak, Przemyslaw Mitkowski, Petr Neuzil, Adam Sokal, Andrejs Erglis, Karl-Heinz Kuck
Journal: Journal of the American College of Cardiology (2021)
TCT-310 Percutaneous Peridevice Leakage Closure After Insufficient Left Atrial Appendage Occlusion: Results From a Worldwide Collaborative Study
Authors: Kerstin Piayda, Kolja Sievert, Domenico Della Rocca, Oluwaseun Adeola, Mohamad Alkhouli, David Yoo, Tomás Benito-González, Ignacio Cruz-Gonzalez, Roberto Galea, Carsten Skurk, Ole De Backer, Jens Erik Nielsen-Kudsk, Marek Grygier, Elijah Beaty, Jim Newton, Armando Perez de Prado, Lorenz Raber, Douglas Gibson, Christoffel Van Niekerk, Christopher Ellis, Rodney Horton, Andrea Natale, Iris Grunwald, Tobias Zeus, Horst Sievert
Journal: Journal of the American College of Cardiology (2021)
Clinically translatable gold nanozymes with broad spectrum antioxidant and anti-inflammatory activity for alleviating acute kidney injury
Authors: Dong-Yang Zhang, Tianhui Tu, Muhammad Rizwan Younis, Kathy S Zhu, Hengke Liu, Shan Lei, Junle Qu, Jing Lin, Peng Huang
Journal: Theranostics (2021)

Acute kidney injury (AKI) is associated with aberrant generation of oxidative species and inflammation, leading to high mortality of in-hospitalized patients. Although
心室筋細胞におけるgp130媒介の生存促進性/抗アポトーシス・シグナリングへのPI3K/Akt/BAD経路の関与
Authors: Kuwahara K, Saito Y, Kishimoto I, Miyamoto Y, Harada Mm, Ogawa E, Hamanaka I, Kajiyama N, Takahashi N, Izumi T
Journal: Circulation (1999)
TCT-46 Deformation of Transcatheter Aortic Valve Prostheses: Implications for Hypo-Attenuating Leaflet Thickening
Authors: Miho Fukui, Vinayak Bapat, Santiago Garcia, Marshall Dworak, Go Hashimoto, Hirotomo Sato, Maurice Enriquez-Sarano, John Lesser Lesser, Joao Cavalcante, Paul Sorajja
Journal: Journal of the American College of Cardiology (2021)
Prognostic significance and therapeutic implications of Caveolin-1 in gastrointestinal tract malignancies
Authors: Konstantinos Kamposioras, Maria Vassilakopoulou, Alan Anthoney, Jorge Bariuoso, Davide Mauri, Was Mansoor, Vassilios Papadopoulos, Konstantinos Dimas
Journal: Pharmacology & Therapeutics (2021)
Fenton metal nanomedicines for imaging-guided combinatorial chemodynamic therapy against cancer
Authors: Peng Liu, Ying Peng, Jinsong Ding, Wenhu Zhou
Journal: Asian Journal of Pharmaceutical Sciences (2021)

Chemodynamic therapy (CDT) is considered as a promising modality for selective cancer therapy, which is realized via Fenton reaction-mediated decomposition of endogenous H2O2 to produce toxic hydroxyl radical (•OH) for tumor ablation. While extensive efforts have been made to develop CDT-based therapeutics, their in vivo efficacy is usually unsatisfactory due to poor catalytic activity limited by tumor microenvironment, such as anti-oxidative systems, insufficient H2O2, and mild acidity. To mitigate these issues, we have witnessed a surge in the development of CDT-based combinatorial nanomedicines with complementary or synergistic mechanisms for enhanced tumor therapy. By virtue of their bio-imaging capabilities, Fenton metal nanomedicines (FMNs) are equipped with intrinsic properties of imaging-guided tumor therapies. In this critical review, we summarize recent progress of this field, focusing on FMNs for imaging-guided combinatorial tumor therapy. First, various Fenton metals with inherent catalytic performances and imaging properties, including Fe, Cu and Mn, were introduced to illustrate their possible applications for tumor theranostics. Then, CDT-based combinatorial systems were reviewed by incorporating many other treatment means, including chemotherapy, photodynamic therapy (PDT), sonodynamic therapy (SDT), photothermal therapy (PTT), starvation therapy and immunotherapy. Next, various imaging approaches based on Fenton metals were presented in detail. Finally, challenges are discussed, and future prospects are speculated in the field to pave way for future developments.
The value of the basophil activation test in the evaluation of patients reporting allergic reactions to the BNT162b2 mRNA COVID‐19 vaccine
Authors: Marina Labella, Jose Antonio Céspedes, Inmaculada Doña, Mohamed H. Shamji, Ioana Agache, Cristobalina Mayorga, Maria José Torres
Journal: Allergy (2021)

Abstract Background mRNA‐based COVID‐19 vaccines have been reported to induce hypersensitivity reactions (HSR) in a small number of individuals. We aimed to evaluate the real‐world incidence of the BNT162b2 mRNA COVID‐19 vaccine HSR and to determine the value of the basophil activation test (BAT) in the allergological workup of patients reporting these reactions. Methods We prospectively enrolled patients with a clinical history indicative of HSR to the BNT162b2 mRNA COVID‐19 vaccine. The allergological workup included skin testing (STs) and BAT with polyethylene glycol (PEG) and the vaccine. In those with negative allergy assessments, the administration of the second dose of the BNT162b2 mRNA COVID‐19 vaccine was offered. Results Seventeen adults were included. Eleven cases (64.7%) tested negative in the allergological workup and tolerated the re‐administration of the second dose of the vaccine and considered non‐allergic. Six cases (35.3%) were considered allergic and classified into three groups: 2 subjects displayed positive STs and/or BAT to PEG (Group A), two individuals displayed positive BAT to the vaccine (Group B), and in 2 patients with moderate or severe reactions, the culprit was not identified, tested negative to STs and BAT to both PEG and vaccine (Group C). We further evaluated the value of BAT when the results were positive to the vaccine and negative to PEG by performing BAT in controls groups, finding positive BAT results in 50% of controls, all of them recovered from COVID‐19 infection. In contrast, BAT was negative in patients who had not suffered from COVID‐19 disease. Conclusions BAT can be used as a potential diagnostic tool for confirming allergy to PEG excipient but not to the vaccine as a positive result in BAT may indicate a past COVID‐19 infection instead of an allergy.
Ferroptosis Promotes Cyst Growth in Autosomal Dominant Polycystic Kidney Disease Mouse Models
Authors: Xiaoqin Zhang, Linda Xiaoyan Li, Hao Ding, Vicente E. Torres, Chen Yu, Xiaogang Li
Journal: Journal of the American Society of Nephrology (2021)

Autosomal dominant polycystic kidney disease (ADPKD), the most common inherited kidney disease, is regulated by different forms of cell death, including apoptosis and autophagy. However, the role in ADPKD of ferroptosis, a recently discovered form of cell death mediated by iron and lipid metabolism, remains elusive.
TCT-237 Development and Validation of Novel Risk Stratification Model for Slow Flow/No Reflow During Primary Percutaneous Coronary Intervention
Authors: Rajesh Kumar, Ali Ammar, Jawaid Sial, Kamran Khan, Jehangir Ali Shah Sheerazi, Ashok Kumar, Musa Karim, Shueeta Shueeta
Journal: Journal of the American College of Cardiology (2021)
TCT-80 Feasibility and Prognostic Meaning of the Automated Detection of Lipid Core Burden Index at Optical Coherence Tomography: Post Hoc Analysis of the CLIMA Study
Authors: Flavio Biccirè, Simone Budassi, Francesc Isidori, Eugenio Lella, Valeria Marco, Mario Albertucci, Yukio Ozaki, Alessio La Manna, Enrico Romagnoli, Christos Bourantas, Giulia Paoletti, Franco Fabbiocchi, Laura Gatto, Alessandro Sticchi, Francesco Burzotta, Nevio Taglieri, Giuseppe Calligaris, Eloisa Arbustini, Fernando Alfonso, Francesco Prati
Journal: Journal of the American College of Cardiology (2021)
Abstract 12346: Palmitoylation-Dependent Regulation of RhoGTPase Signaling and Cardiac Hypertrophy
Authors: Matthew J Brody, Jeffery D Molkentin
Journal: Circulation (2018)

S-palmitoylation is a reversible lipid modification that regulates trafficking, localization, activity, and/or stability of protein substrates by serving as a fatty acid anchor to cell membranes. H...
Getting molnupiravir to patients in a timely way is likely to be problematic
Authors: Peter M B English
Journal: BMJ (2021)

I look forward to seeing more details about the effects of molnupiravir on covid-19, preferably in a peer reviewed publication.1

I have commented on this elsewhere.2

I was involved in trying to get people with flu-like symptoms antiviral chemoprophylaxis in the early days of the 2010 flu pandemic. Because ministers had said that everybody with such symptoms must be given chemoprophylaxis, we were not permitted to prioritise those at greatest …
TCT-78 Diagnostic Value of CT-FFR for the Detection of Coronary Artery Disease in Routine TAVR Work-Up
Authors: Joyce Peper, Leonie Becker, Wilbert Bor, Jorn Brouwer, Vincent Nijenhuis, Dirk-Jan van Ginkel, Benno Rensing, Jurrien Ten Berg, Leo Timmers, Tim Leiner, Martin Swaans
Journal: Journal of the American College of Cardiology (2021)
Deficiency in X-linked inhibitor of apoptosis protein promotes susceptibility to microbial triggers of intestinal inflammation
Authors: Anne Strigli, Shreya Gopalakrishnan, Yvonne Zeissig, Marijana Basic, Jun Wang, Tobias Schwerd, Shauni Doms, Kenneth Peuker, Jelka Hartwig, Jürgen Harder, Pia Hönscheid, Philipp Arnold, Thomas Kurth, Fabian Rost, Britt-Sabina Petersen, Michael Forster, Andre Franke, Judith R. Kelsen, Meino Rohlfs, Christoph Klein, Aleixo M. Muise, Neil Warner, Ryusuke Nambu, Julia Mayerle, Helga-Paula Török, Andreas Linkermann, Michael H. Muders, Gustavo B. Baretton, Jochen Hampe, Daniela E. Aust, John F. Baines, André Bleich, Sebastian Zeissig
Journal: Science Immunology (2021)

Inflammatory bowel disease (IBD) is characterized by inappropriate immune responses to the microbiota in genetically susceptible hosts, but little is known about the pathways that link individual genetic alterations to microbiota-dependent inflammation. Here, we demonstrated that the loss of X-linked inhibitor of apoptosis protein (XIAP), a gene associated with Mendelian IBD, rendered Paneth cells sensitive to microbiota-, tumor necrosis factor (TNF)–, receptor-interacting protein kinase 1 (RIPK1)–, and RIPK3-dependent cell death. This was associated with deficiency in Paneth cell–derived antimicrobial peptides and alterations in the stratification and composition of the microbiota. Loss of XIAP was not sufficient to elicit intestinal inflammation but provided susceptibility to pathobionts able to promote granulomatous ileitis, which could be prevented by administration of a Paneth cell–derived antimicrobial peptide. These data reveal a pathway critical for host-microbial cross-talk, which is required for intestinal homeostasis and the prevention of inflammation and which is amenable to therapeutic targeting.
Trends in Insulin Prescribing for Patients With Diabetes During the COVID-19 Pandemic in the US
Authors: Ismaeel Yunusa, Bryan L. Love, Chao Cai, Tessa Hastings, Claiborne E. Reeder, Elizabeth W. Blake, Cynthia Phillips
Journal: JAMA Network Open (2021)

The vertical dotted lines indicate the start of the COVID-19 pandemic on March 16, 2020.Interrupted time series analysis was performed with regression and Newey-West standard errors lag(0).
Inequalities in initiation of COVID19 vaccination by age and population group in Israel- December 2020-July 2021
Authors: Yanay Gorelik, Emilia Anis, Michael Edelstein
Journal: The Lancet Regional Health - Europe (2021)

COVID19 vaccination coverage in Israel varies among population groups. Comparing crude coverage between groups is misleading because of different age structures and socio-economic differences. To describe inequalities in COVID19 vaccine initiation in Israel we analysed the interaction of age and population groups in terms of dose 1 vaccine coverage.We calculated cumulative age-specific first COVID19 vaccine coverage by population group (Ultra-Orthodox Jewish, Arab, General Jewish). We calculated the relative differences in vaccine coverage between population groups within each age group, and between age groups within each population, using ANOVA and binomial regression after adjusting for socio-economic status.8,507,723 individuals in 268 cities were included. Compared with the general Jewish population, coverage was lowest in the Ultra-Orthodox population in all age groups (range -12% among 60+ to -52.8% among 10-19 years olds, p<0.001). In all groups, the proportion of vaccinated individuals in younger age groups relative to those aged 60+ decreased with decreasing age and were smallest in the Ultra-Orthodox groups. For example, within the general Jewish population, people aged 20-29 were 14% less likely to be vaccinated than those aged 60+ while within the Ultra-Orthodox population it was 34.5.In all age groups, the Ultra-Orthodox population had the lowest vaccine coverage. Differences persisted after adjusting for socio-economic status. The younger the age group, the more Ultra-Orthodox Jews were diverging from age peers in terms of initiating COVID19 vaccination, suggesting a generational effect. Tailored approaches are urgently required to encourage vaccination among under-immunized groups in Israel.No specific funding was received.
Cardiovascular Progerin Suppression and Lamin A Restoration Rescue Hutchinson-Gilford Progeria Syndrome
Authors: Amanda Sánchez-López, Carla Espinós-Estévez, Cristina González-Gómez, Pilar Gonzalo, María J. Andrés-Manzano, Víctor Fanjul, Raquel Riquelme-Borja, Magda R. Hamczyk, Álvaro Macías, Lara del Campo, Emilio Camafeita, Jesús Vázquez, Anna Barkaway, Loïc Rolas, Sussan Nourshargh, Beatriz Dorado, Ignacio Benedicto, Vicente Andrés
Journal: Circulation (2021)

Background: Hutchinson-Gilford progeria syndrome (HGPS) is a rare disorder characterized by premature aging and death mainly because of myocardial infarction, stroke, or heart failure. The disease is provoked by progerin, a variant of lamin A expressed in most differentiated cells. Patients look healthy at birth, and symptoms typically emerge in the first or second year of life. Assessing the reversibility of progerin-induced damage and the relative contribution of specific cell types is critical to determining the potential benefits of late treatment and to developing new therapies. Methods: We used CRISPR-Cas9 technology to generate Lmna HGPSrev/HGPSrev ( HGPSrev ) mice engineered to ubiquitously express progerin while lacking lamin A and allowing progerin suppression and lamin A restoration in a time- and cell type–specific manner on Cre recombinase activation. We characterized the phenotype of HGPSrev mice and crossed them with Cre transgenic lines to assess the effects of suppressing progerin and restoring lamin A ubiquitously at different disease stages as well as specifically in vascular smooth muscle cells and cardiomyocytes. Results: Like patients with HGPS, HGPSrev mice appear healthy at birth and progressively develop HGPS symptoms, including failure to thrive, lipodystrophy, vascular smooth muscle cell loss, vascular fibrosis, electrocardiographic anomalies, and precocious death (median lifespan of 15 months versus 26 months in wild-type controls, P &lt;0.0001). Ubiquitous progerin suppression and lamin A restoration significantly extended lifespan when induced in 6-month-old mildly symptomatic mice and even in severely ill animals aged 13 months, although the benefit was much more pronounced on early intervention (84.5% lifespan extension in mildly symptomatic mice, P &lt;0.0001, and 6.7% in severely ill mice, P &lt;0.01). It is remarkable that major vascular alterations were prevented and lifespan normalized in HGPSrev mice when progerin suppression and lamin A restoration were restricted to vascular smooth muscle cells and cardiomyocytes. Conclusions: HGPSrev mice constitute a new experimental model for advancing knowledge of HGPS. Our findings suggest that it is never too late to treat HGPS, although benefit is much more pronounced when progerin is targeted in mice with mild symptoms. Despite the broad expression pattern of progerin and its deleterious effects in many organs, restricting its suppression to vascular smooth muscle cells and cardiomyocytes is sufficient to prevent vascular disease and normalize lifespan.
Resident macrophage-dependent immune cell scaffolds drive anti-bacterial defense in the peritoneal cavity
Authors: Adrián Vega-Pérez, Laura H Villarrubia, Cristina Godio, Alejandra Gutiérrez-González, Lidia Feo-Lucas, Margarita Ferriz, Natalia Martínez-Puente, Julieta Alcaín, Alfonso Mora, Guadalupe Sabio, María López-Bravo, Carlos Ardavín
Journal: Immunity (2021)
TCT-456 Carotid Artery Revascularization Using Second-Generation Stents Versus Surgery: A Meta-Analysis of Clinical Outcomes
Authors: Adam Mazurek, Krzysztof Malinowski, Francesco Setacci, Francesco Speziale, Carlo Setacci, Andrej Schmidt, Waclaw Kuczmik, Piotr Musialek
Journal: Journal of the American College of Cardiology (2021)
2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: Executive Summary
Authors: Martha Gulati, Phillip D. Levy, Debabrata Mukherjee, Ezra Amsterdam, Deepak L. Bhatt, Kim K. Birtcher, Ron Blankstein, Jack Boyd, Renee P. Bullock-Palmer, Theresa Conejo, Deborah B. Diercks, Federico Gentile, John P. Greenwood, Erik P. Hess, Steven M. Hollenberg, Wael A. Jaber, Hani Jneid, José A. Joglar, David A. Morrow, Robert E. O’Connor, Michael A. Ross, Leslee J. Shaw
Journal: Journal of the American College of Cardiology (2021)
Engineering DNA Nanostructures to Manipulate Immune Receptor Signaling and Immune Cell Fates
Authors: Chung Yi Tseng, Wendy Xueyi Wang, Travis Robert Douglas, Leo Y. T. Chou
Journal: Advanced Healthcare Materials (2021)

Immune cells sense, communicate, and logically integrate a multitude of environmental signals to make important cell-fate decisions and fulfill their effector functions. These processes are initiated and regulated by a diverse array of immune receptors and via their dynamic spatiotemporal organization upon ligand binding. Given the widespread relevance of the immune system to health and disease, there have been significant efforts toward understanding the biophysical principles governing immune receptor signaling and activation, as well as the development of biomaterials which exploit these principles for therapeutic immune engineering. Here, how advances in the field of DNA nanotechnology constitute a growing toolbox for further pursuit of these endeavors is discussed. Key cellular players involved in the induction of immunity against pathogens or diseased cells are first summarized. How the ability to design DNA nanostructures with custom shapes, dynamics, and with site-specific incorporation of diverse guests can be leveraged to manipulate the signaling pathways that regulate these processes is then presented. It is followed by highlighting emerging applications of DNA nanotechnology at the crossroads of immune engineering, such as in vitro reconstitution platforms, vaccines, and adjuvant delivery systems. Finally, outstanding questions that remain for further advancing immune-modulatory DNA nanodevices are outlined.
Impact of grade II-IV graft-versus-host disease (GVHD) on survival in patients with non-remission acute leukemia.
Authors: Ohnishi M, Kanda Y, Iijima K, Ando T, Hamaki T, Nakai K, Saito T, Kami M, Makimoto A, Tanosaki R, Takaue Y, Mineishi S
Journal: Blood (2001)
Genotype-Phenotype Correlation and Molecular Heterogeneity in Pyruvate Kinase Deficiency: Data from the PKD Natural History Study
Authors: Paola Bianchi, Elisa Fermo, Kimberly Lezon-Geyda, Patrick G. Gallagher, Richard van Wijk, Eduard J. Van Beers, Hassan M. Yaish, Janet L. Kwiatkowski, Peter E. Newburger, Yaddanapudi Ravindranath, Oliver Andres, Wilma Barcellini, D. Holmes Morton, Bertil Glader, Stefan W. Eber, Satheesh Chonat, Nina Kollmar, Jenny M. Despotovic, Christine M. Knoll, Kevin H.M. Kuo, Dagmar Pospisilova, Yves D. Pastore, Alexis A Thompson, Winfred Wang, Marcin W. Wlodarski, Jennifer A. Rothman, Heng Wang, Suzanne Holzhauer, Vicky R. Breakey, Joachim B. Kunz, Sujit Sheth, Mukta Sharma, Melissa J. Rose, Heather A. Bradeen, Melissa N. McNaull, Gabrielle P. Ooyama, Nolan Neu, Hasan Al-Sayegh, Wendy B. London, Rachael F. Grace
Journal: Blood (2017)
Cancer control in Latin America and the Caribbean: recent advances and opportunities to move forward
Authors: Carlos H Barrios, Gustavo Werutsky, Alejandro Mohar, Ana S Ferrigno, Bettina G Müller, Brittany L Bychkovsky, Carlos José Castro E, Claudia J Uribe, Cynthia Villarreal-Garza, Enrique Soto-Perez-de-Celis, Francisco Gutiérrez-Delgado, Ji Seok Kim, Julia Ismael, Lucia Delgado, Luiz A Santini, Nelson Teich, Pamela C Chavez, Pedro E R Liedke, Pedro Exman, Romualdo Barroso-Sousa, Stephen D Stefani, Suyapa A Bejarano Cáceres, Taiane F Rebelatto, Tania Pastrana, Yanin Chavarri-Guerra, Yolanda Vargas, Eduardo Cazap
Journal: The Lancet Oncology (2021)
Pilot Randomized Controlled Trial of an Advance Care Planning Video Decision Tool for Patients With Advanced Liver Disease
Authors: Nneka N. Ufere, Blair Robinson, John Donlan, Teresa Indriolo, Judith Bloom, Abigail Scherrer, Nancy M. Mason, Arpan Patel, Jennifer C. Lai, Raymond T. Chung, Angelo Volandes, Areej El-Jawahri
Journal: Clinical Gastroenterology and Hepatology (2021)
TCT-213 Transcatheter Edge-to-Edge Mitral Valve Repair in Patients With Low, Intermediate, and High Frailty
Authors: Aaqib Malik, Jayakumar Sreenivasan, Alexandros Briasoulis, Syed Zaid, Wilbert Aronow, Syed Haidry, Hasan Ahmad, Ryan Kaple, Gilbert Tang
Journal: Journal of the American College of Cardiology (2021)