tbuckley/cabot-search huggingface dataset:
Defusing adverse effects of anticancer drugs
Authors: B. Merz
Journal: JAMA (1983)

Doxorubicin hydrochloride and daunorubicin hydrochloride, two of the most potent drugs in the anticancer arsenal, share, in addition to bone marrow suppression, another serious—sometimes fatal—adverse effect: cardiotoxicity. Recently, however, research at several institutions has begun to yield ways to eliminate this drawback and, in some cases, increase the drugs' potencies in the process. Researchers at SRI International, Menlo Park, Calif, and Adria Laboratories, Inc, Dublin, Ohio, have developed a doxorubicin derivative that appears to be orders of magnitude more potent than the parent molecule yet free of its main side effect. The newly synthesized molecule, 3′-deamino-3′-(3-cyano-4-morpholinyl) doxorubicin, called "A-489," has been tested against two forms of leukemia and a solid tumor in mice, as well as in DNA/RNA synthesis inhibition trials in cultured tumor cells. The studies indicate that the optimum dose of A-489 is 600 times lower than that of doxorubicin. Results are the same whether the substance is
UREMIC APHASIA.
Authors: DAVID RIESMAN
Journal: JAMA (1902)

While the ultimate essence of uremia is unknown, everything points to the conclusion that the condition is a form of autointoxication, in whose production disease of the kidneys plays an important, but perhaps not the only rôle. The poison, like a number of others originating within the body, acts chiefly on the nervous system, although it is probable that no organ or tissue escapes its malign influence, inasmuch as it is conveyed to all parts of the economy by the blood. <h3>VARIETIES OF APHASIA.</h3> In their protean and variable character, the nervous manifestations of uremia are comparable to those of hysteria. † Like the latter, they are sometimes so distinctly focal as to suggest the existence of a gross organic cerebral lesion, which the autopsy, however, generally shows to be absent. Among these focal symptoms the most interesting are hemiplegia, monoplegia, monospasm and aphasia. Objectively these four manifestations of uremia
Basic fibroblast growth factor may attenuate susceptibility to ventricular tachyarrhythmias in chronically ischemic porcine myocardium John D. Day, Mehrdad Rezaee, Sung H. Chun, Alan C. Yeung, Paul G. Yock, Peter J. Fitzgerald, Andrew Carter, Abel L. Robertson, Ruey J. Sung. Stanford University Medical Center, Stanford, CA
Journal: Journal of the American College of Cardiology (2001)
Abstract 440: A Lamin A/C Haploinsufficiency Model of Cardiomyopathy Using Patient-Specific iPSC Derived Cardiomyocytes Demonstrates Impaired Contractility
Authors: Shan Parikh, Lili Wang, Kevin Bersell, Marcia Blair, Andrea Murad, Quinn S Wells, Bjorn C Knollmann
Journal: Circulation Research (2017)

Background: Lamin A/C (LMNA) mutations are the second most common cause of familial dilated cardiomyopathy (DCM). LMNA encodes nuclear lamins which are intermediate filaments of the inner nuclear membrane. Patients with LMNA DCM present with early signs of arrhythmias and often display a rapid deterioration in cardiac function. Previous induced pluripotent derived stem cell (iPSC) modeling of cardiac laminopathy did not demonstrate defects in cardiomyocyte (CM) contractility nor provide evidence of arrhythmogenesis. Developing a robust human model that recapitulates disease manifestations of LMNA cardiomyopathy is a critical step for understanding CM-intrinsic defects contributing to disease pathogenesis. Purpose: As such, our lab hypothesized that iPSC-CMs derived from a laminopathy patient would recapitulate the contractile dysfunction of the disease if studied in monolayer using flexible matrigel substrate. Methods: Patients with symptomology indicative of LMNA DCM were recruited for clinical testing. Peripheral blood mononuclear cells were isolated and reprogrammed into iPSCs. CMs were generated using a chemical differentiation method and then subjected to molecular and functional assessment. Cardioexcyte96 based detection of impedance was utilized for analysis of contractility of iPSC-CMs in a monolayer. Results/Conclusions: We identified a large pedigree with DCM in which affected individuals had a putatively pathogenic mutation within LMNA. Western blot analyses demonstrated that lamin A/C can be detected in iPSC-CMs with reduced expression in mutant cells. Mutant iPSC-CMs in a monolayer demonstrate both increased time for contraction (+55.1 msec P&lt;.0001) and relaxation (+44.8 msec P&lt;.0001) compared to control. Our results are the first to provide evidence for contractile dysfunction in an iPSC-CM model of cardiac laminopathy. In addition, this work highlights the utility of impedance based measurement of contractility as a robust outcome that can be applied to high throughput discovery of therapeutic interventions in this disease model.
GW28-e0967 A study on the mechanism of the TGF-ß in Ginsenoside Rb1 against the intrinsic aging of mouse brain
Authors: Bin Zhou, Min Wang, Shujie Yu, Lin Wu, Dinghui Liu, Yesheng Ling, Yong Liu, Baoshun Hao, Lin Chen, Xiaoxian Qian
Journal: Journal of the American College of Cardiology (2017)
Abstract 368: The Effect of Long-term Administration of PGE1 on the Morphological Change of Ductus Arteriosus
Authors: Ryuma Iwaki, Hironori Matsuhisa, Yoshihiro Oshima, Masato Hoshino, Susumu Minamisawa, Toru Akaike, Kiyozo Morita, Gen Shinohara, Yukihiro Kaneko, Hiroyuki Morishita, Masashi Takahashi, Naoto Yagi, Takuro Tsukube, Yutaka Okita
Journal: Circulation Research (2017)

Introduction: Plostagrandin E 1 (PGE 1 ) is essential for maintaining the ductus arteriosus (DA) in ductal-dependent congenital heart disease. Recently, relatively long-term administration of PGE 1 became common, especially in patient with hypoplastic left heart syndrome (HLHS) . Staged Norwood approach which consists of bilateral pulmonary artery banding, PGE 1 infusion, and Norwood procedure beyond newborn period provided excellent survival benefit. However, microstructural changes of DA after long-term PGE 1 administration remain unknown. Therefore, we sought to investigate their features of DA after long-term PGE 1 administration using synchrotron based X-ray phase-contrast tomography (XPCT), a novel modality to inspect biological soft tissue, and pathological scrutiny including DA specific immunostaining. Methods: Seventeen DA tissues of HLHS were obtained during Norwood procedure. The median duration of PGE 1 was 48 days (Range 3-123). Radiographic microstructural analysis of DA was performed using X-ray phase contrast tomography at SPring-8 (Hyogo, Japan). Histological changes focused on elastic fiber and smooth muscle formation were evaluated by Elastica van Gieson staining, and expression of prostaglandin E2 receptor EP4 was evaluated by immunohistochemical analysis. Results: XPCT study showed a sclerotic changes of ductal media. There was a significant correlation between the duration of PGE 1 infusion and the mass density of ductal media (R: 0.723, p=0.001). Histological study showed that the duration of PGE1 infusion was positively correlated with the elastic fiber formation (R: 0.795, P=0.002), and negatively correlated with smooth muscle formation (R: -0.83, P&lt;0.001). The EP4 expression was disappeared in all DA. Conclusion: Long-term administration of PGE 1 induced elastogenesis and density growth of the ductal media. In addition, downregulation of EP4 was observed. These results suggested that dosage of PGE 1 could be decreased after definite period of administration.
Deaths
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New Names
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Low-intensity Pulsed Ultrasound regulates alveolar bone homeostasis in experimental Periodontitis by diminishing Oxidative Stress: Erratum
Authors: Siqi Ying, Minmin Tan, Ge Feng, Yunchun Kuang, Duanjing Chen, Jie Li, Jinlin Song
Journal: Theranostics (2022)

[This corrects the article DOI: 10.7150/thno.42508.].
Current Comment
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P055: Methylation Levels at Growth Differentiation Factor- 15 Related Cpg Sites Are Not Related to Death Risk From Cardiovascular Disease Among Monozygotic Male Twins Discordant for Cardiovascular Disease: National Heart, Lung, and Blood Institute Twin Study
Authors: Pallavi Mukherji, Ming Leung, Wael El- Rifai, Ruth Krasnow, Terry Reed, Jun Dai
Journal: Circulation (2018)

Background: Growth differentiation factor- 15 (GDF-15) is positively associated with the risk of mortality from acute coronary syndrome and chronic heart failure. A prior study reported decreased methylation at four promising GDF-15 related CpG sites tended to be associated with myocardial infarction, however, little is known of the association of methylation levels at these sites with the risk for cardiovascular disease (CVD) death. Objective: To evaluate whether methylation levels at the four GDF-15 CpG sites (site A: cg13033585, site B: cg16936953, site C: cg17150809, and site D: cg18608055) are associated with death from CVD, independent of genes and shared environmental factors. Method: We included 19 male monozygotic twin pairs discordant for death from CVD through December 31, 2014 from the National Heart, Lung, and Blood Institute (NHLBI) Twin Study initiated in 1969-1973. Buffy coat DNA samples were collected in exam 3 (1986-87). The vital status was followed up through December 31, 2014. Genome wide DNA methylation levels were quantified using the Illumina Infinium HumanMethylation450 (450K) BeadChip. Conditional logistic models were used to estimate hazard ratio (HR). Known baseline CVD risk factors were adjusted. Results: The twins’ mean baseline age was 50.4 years with standard deviation of 2.4. The crude HR was 0.01 (95% CI: 0.00, 2854.46), 2038.89 (95%CI: 0.01, 3.84 X 10 8 ), 0.12 (95% CI: 0.00, 55.99), and 2.08 (95% CI: 0.00, 1.26 X 10 6 ) for sites A, B, C, and D, respectively, suggesting that our sample size was small to test these sites. After adjustment for body mass index, years of education, and Framingham risk scores, HR was 0.03 (95% CI: 0.00, 45281.06) for site A, 700.96 (95% CI: 0.00, 2.32 X10 8 ) for site B, 0.00 (95% CI: 0.00, 7.35) for site C, and 0.81 (95% CI: 0.00, 1.44 X 10 6 ) for site D. Further adjustment for white blood cell subtypes dramatically changed HRs and/or largely widened 95% CIs, suggesting potential overadjustment bias: 0.01 (95% CI:0.00, 1.89 X 10 10 ) for site A, 2.78 X 10 8 (95% CI: 0.00, 7.84 X 10 21 ) for site B, 0.00 (95% CI: 0.00, 620.94) for site C, and 1.69 (95% CI: 0.00, 4.18 X 10 13 ) for site D. Conclusion: DNA methylation levels at the GDF-15 CpG sites are not associated with death risk from cardiovascular disease independent of genes and shared environment.
Rupioid Psoriasis
Authors: Ken Hiu-Kan Ip, Harriet Sara Cheng, Fergus G. Oliver
Journal: JAMA Dermatology (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Misdiagnosis of drug abuse
Authors: D. T. Teitelbaum
Journal: JAMA (1969)

To precipitate Beyond the prepuce.—stoned! G. U. Know "You're in" he said A stream of thought To take a ride Down diuretic way And view the plumbing governor Of the mammal. Have a squirt In this enlightened dignity By the peahouse of the August Moon. Here at the way station to the bladder Upstream at the Reniform In the land of the cortical. A jungle of glomerular raspberries What strain filter... And flow the Nile Past the renal pyramids. Down medullary way Calyxing along The integral of calculus And its accretion To precipitate On the fate of phos To rock the boat As I book passage south For spasmodic venture ahead In the rapids of turbulence The muscle is smooth... Prost(r)ate in pain To (w) ring the bladder neck I encyst Dump me down ptosis With my ragged edges Down the tight rope The ureteral ladder Step by step Unto
Erratum for the Research Article: “The Role of Dimethylarginine Dimethylaminohydrolase in Idiopathic Pulmonary Fibrosis” by S. S. Pullamsetti, R. Savai, R. Dumitrascu, B. K. Dahal, J. Wilhelm, M. Konigshoff, D. Zakrzewicz, H. A. Ghofrani, N. Weissmann, O. Eickelberg, A. Guenther, J. Leiper, W. Seeger, F. Grimminger, R. T. Schermuly
Journal: Science Translational Medicine (2022)

[Figure: see text].
Geographical distribution of systemic sclerosis in Canada: An ecologic study based on the Canadian Scleroderma Research Group
Authors: Anastasiya Muntyanu, Lydia Ouchene, Siriu Zhou, Marie Hudson, Mohsen Rezaeian, Avery LaChance, Ivan V. Litvinov, Murray Baron, Elena Netchiporouk, M. Baron, M. Hudson, G. Gyger, J. Pope, M. Larche, N. Khalidi, A. Masetto, E. Sutton, T.S. Rodriguez-Reyna, N. Maltez, C. Thorne, P.R. Fortin, A. Ikic, D. Robinson, N. Jones, S. LeClercq, P. Docherty, D. Smith, M. Fritzler
Journal: Journal of the American Academy of Dermatology (2022)
Fewer Than Three Doses of Cervical Cancer Vaccine Effective
Journal: JNCI Journal of the National Cancer Institute (2011)

Fewer Than Three Doses of Cervical Cancer Vaccine EffectiveFewer than three doses of the human papillomavirus (HPV) vaccine Cervarixmay be just as effective as the standard three-dose regimen when it comes to preventive measures against cervical cancer, according to a new study published September 9 in the Journal of the National Cancer Institute.Across the globe, cervical cancer is the third most common cancer among women, and HPV types 16 and 18 are a large contributor to the development of the disease.The HPV 16/18 vaccine is currently given in three doses over six months, making it an expensive and sometimes difficult to complete.No previous study has reported on the efficacy of fewer doses of the vaccine in protecting women against the HPV infections that lead to cervical cancer.To determine whether a lower number of doses of the Cervarix vaccine would be efficacious, Aimée R. Kreimer, Ph.D., of the Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, and a team of researchers conducted an analysis of data from the NCI-sponsored Costa Rica Vaccine Trial, where women received either three doses of Cervarix or the control vaccine.Of the 7,466 women enrolled, 20% received fewer than three doses due to involuntary factors, such as pregnancy or referrals to colposcopy during routine patient management.The researchers compared the frequency of persistent infection with HPV 16 or 18 in the HPV and control arms of the trial during 4 years of follow-up in women who received one or two doses of the vaccine and in women who received 3 doses.Once researchers excluded women who had no follow-up or who were HPV16 and HPV18 DNA positive at the time of enrollment, 5,967 women received three doses of the treatment, 802 received two doses and 384 women received only one dose.
Cluster of Severe Acute Respiratory Syndrome Cases Among Protected Health-Care Workers—Toronto, Canada, April 2003
Journal: JAMA (2003)

Infections among health-care workers (HCWs) have been a common feature of severe acute respiratory syndrome (SARS) since its emergence. The majority of these infections have occurred in locations where infection-control precautions either had not been instituted or had been instituted but were not followed. Recommended infection-control precautions include the use of negative-pressure isolation rooms where available; N95 or higher level of respiratory protection; gloves, gowns, and eye protection; and careful hand hygiene. This report summarizes a cluster of SARS cases among HCWs in a hospital that occurred despite apparent compliance with recommended infection-control precautions.
Heart rate turbulence is influenced by heart rate, age, LVEF, NYHA class, diabetes, drugs and frequency of ventricular ectopics in patients after acute myocardial infarction-EMIAT substudy Yee Guan Yap, A. John Camm, Georg Schmidt, Marek Malik. St. George's Hospital Medical School, London, United Kingdom
Journal: Journal of the American College of Cardiology (2001)
Myopericarditis as an Extra-Intestinal Manifestation of Crohn’s Disease: A Case Report
Authors: Rohan Prasad, Surya Chennupati, Tyler Kemnic, Abdullah Al-abcha, Manel Boumegouas, Shilpa Kavuturu
Journal: Clinical Cardiology and Cardiovascular Interventions (2022)

Introduction: Myopericarditis is an uncommon manifestation of Crohn’s disease. Interestingly enough, it can present in a patient without any acute bowel symptoms. Case Presentation: A 21-year-old male with a medical history of Crohn’s disease and eosinophilic esophagitis presented to the hospital with chest pain and fever. Blood work revealed elevated troponin, C-reactive protein, and sedimentation rate levels. Electrocardiogram (EKG) showed diffuse ST elevation in all leads. Transthoracic echocardiogram (TTE) demonstrated a small pericardial effusion without valvular abnormalities. The patient was diagnosed with myopericarditis. Extensive etiological workup was negative, in the absence of other explanations, it was attributed to his Crohn’s disease. The patient was started on colchicine and ibuprofen. Out-patient follow-up revealed resolution of symptoms. Conclusion: This case reports the rare occurrence of myopericarditis and Crohn’s disease. Inflammatory bowel disease as a cause of myopericarditis has been reported in some cases within the literature; however, there is no definitive mechanism known.