tbuckley/cabot-search huggingface dataset:
Abstract 1105: Gadofluorine M-Cy 3, a Novel Paramegnetic Contrast Agent for the in vivo and Histolgical Identification of Transplanted Cells.
Authors: Eric Adler, Anne Bystrup, Karen Saebo, Venketesh Mani, Steve Giovannone, Wilson Young, Joseph Frank, Joachim Weinmann, Gordon Keller, Zahi Fayad
Journal: Circulation (2007)

PURPOSE: Gadofluorine M with a fluorescent dye (GdFMCy3) is a lipophilic paramegnetic contrast agent that is readily absorbed by cultured cells. We hypothesized that this agent would be superior to iron oxide based techniques for cell tracking post cell transplantation. METHODS: Embryonic Stem Cell derived cardiac progenitor cells (ES-CPCs) were generated using previously established methods and incubated for 12 hours with 5 mM GdFMCy3, or transfected with iron oxide using published protocols. Cell survival was &gt;95% for cells incubated with both GdFMCy3 and iron. 500,000 cells labelled with GdFMCy3, iron oxide or control (no contrast agent) were directly injected into the myocardium of mice (n=5/group). Mice were scanned over a two week interval post injection at 9.4T using gated T1-weighted sequences (GdFMCy3), T2* weighted GRE sequences (iron oxide) or the positive contrast sequence GRASP (iron oxide). Mice were sacrificed and the hearts sectioned for microscopy. Perl staining and fluorescence microscopy were used to identify iron oxide and GdFMCy3 within the myocardium, respectively. RESULTS: GdFMCy3 labelled cells were successfully identified in vivo at 9.4T (figure panel B). Good correlation between MRI and histology was observed for both cell labels (figure ). Contrast to noise ratios were significantly higher in the GdFMCy3 group relative to the iron oxide group (figure ). CONCLUSIONS: GdFM-Cy3 is readily taken up by stem cells and easily identified by both MRI and fluorescence microscopy. Given its superior contrast to noise ratio GdFM-Cy3 may be an excellent alternative to iron oxide for in vivo detection and tracking of transplanted cells.
Increased incidence of cardiotoxicity after infusional 5-fluorouracil, cisplatin and docetaxel combination chemotherapy in patients with locally advanced head and neck cancer
Authors: A. Smaradottir, A. Siddiqi, C. Ray, J. Haider, M. Azrin, U. Hegde
Journal: Journal of Clinical Oncology (2005)

5568 Background: Infusional 5 fluorouracil (5FU) combination with cisplatin remain the most active regimen in previously untreated patients with locally advanced head and neck cancer. Recent combination of this regimen with taxanes have further improved the overall responses suggesting its potential for improved survival. Infusional 5FU is described to cause cardiotoxicity, reported between 4–16% in case series. We report an experience of increased cardiac events in patients receiving chemotherapy containing infusional 5FU, docetaxel and cisplatin (TPF). Methods: A retrospective review of medical records of all patients with locally advanced squamous cell carcinoma of the head and neck treated with TPF regimen from January 2002 to January 2004. The objective of the review was to identify patients who had experienced cardiac events such as chest pain consistent with angina or myocardial infarction, syncope, or cardiac arrhythmias after initiation of infusional 5FU, requiring interruption of treatment. Investigations included electrocardiogram, echocardiogram, holter monitoring and cardiac catheterization. Results: Twelve patients with head and neck cancer (eleven male and one female) were treated with TPF regimen during this 2-year period. The mean age was 64 years. All patients had stage III or IV disease. Five of the twelve patients (42%) experienced significant cardiac event that include: One death due to massive myocardial infarction, angina pectoris in two patients with ischemic changes on EKG. In both of these patients, an angiogram was normal but significant ventricular dysfunction became apparent during treatment. One patient had a syncopal episode with arrhythmia, and echocardiogram showed ventricular dysfunction. Finally, one patient had episodes of paroxysmal hypotension. 5FU was discontinued in all the patients that experienced cardiotoxicity. Conclusions: Infusional 5FU with docetaxel and cisplatin may have higher cardio- toxicity. The incidence noted in our small retrospective series is concerning and warrants prospective monitoring of increased cardiac toxicity in the taxane containing 5FU regimens. No significant financial relationships to disclose.
Abstract 1125: Mulberry Leaf Ameliorates The Production Of Adipocytokines By Inhibiting Oxidative Stress In White Adipose Tissue In db/db Mice
Authors: Masayuki Sugimoto, Hidenori Arai, Yukinori Tamura, Toshinori Murayama, Koh Ono, Hiroyuki Ariyasu, Takashi Akamizu, Toru Kita, Kaeko Kamei, Masayuki Yokode
Journal: Circulation (2007)

Mulberry leaf (ML) is commonly used to feed silkworms. Previous study showed that ML ameliorates atherosclerosis. However, its mechanism is not completely understood. Because dysregulated production of adipocytokines is involved in the development of the metabolic syndrome and cardiovascular disease, we examined the effect of ML on the production of adipocytokines and metabolic disorders related to the metabolic syndrome, and compared its effect with that of a PPARγ agonist, pioglitazone (Pio). By treating obese diabetic db/db mice with ML, Pio, and their combination, we investigated the mechanism by which they improve metabolic disorders. In this study, db/+m (lean control) and db/db mice were fed a standard diet with or without 3% (w/w) ML and/or 0.01% (w/w) Pio for 12 weeks from 9 weeks of age. At the end of the experiment we found that ML decreased plasma glucose and triglyceride by 32% and 30%, respectively. Interestingly, administration of ML in addition to Pio showed additive effects; further 40% and 30% reduction in glucose and triglyceride compared with Pio treatment, respectively. Moreover, administration of ML in addition to Pio suppressed the body weight increase by Pio treatment and reduced visceral/subcutaneous fat ratio by 20% compared with control db/db mice. Importantly, ML treatment increased expression of adiponectin in white adipose tissue (WAT) by 40%, which was only found in db/db mice, not in control db/+m mice. Combination of ML and Pio increased plasma adiponectin concentrations by 25% and its expression in WAT by 17% compared with Pio alone. In contrast, ML decreased expression of TNF-α and MCP-1 by 25% and 20%, respectively, and the addition of Pio resulted in a further decrease of these cytokines by about 45%. To study the mechanism, we examined the role of oxidative stress. ML decreased the amount of lipid peroxides by 43% and the expression of NADPH oxidase subunits in WAT, which was consistent with the results of TNF-α and MCP-1. Thus our results indicate that ML ameliorates adipocytokine dysregulation by inhibiting oxidative stress in WAT of obese mice, and that ML may have a potential for the treatment of the metabolic syndrome as well as reducing adverse effects of Pio.
Bevacizumab in combination with temozolomide in the adjuvant treatment of newly diagnosed glioblastoma multiforme: Preliminary results of a phase II study
Authors: M. K. Nicholas, R. V. Lucas, J. Arzbaecher, N. Paleologos, H. Krouwer, M. Malkin, A. Omar, N. A. Vick
Journal: Journal of Clinical Oncology (2009)

2016 Background: Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor. Current standard treatment consists of fractionated radiotherapy (RT) with daily oral temozolomide (TMZ) chemotherapy followed by 6 months of adjuvant TMZ chemotherapy. Median survival is 14.3 months. Because GBM is characterized by vascular proliferation and produces high levels of vascular endothelial growth factor (VEGF), attempts to better control the disease with targeted anti-angiogenesis therapies are underway. Here, we report preliminary safety and tolerability data of bevacizumab (BV) when added to monthly TMZ chemotherapy. Methods: Subjects received standard regional RT to a dose of 60 Gy in 30 fractions with dailyconcurrent TMZ (75 mg/m2) within 3–5 weeks of diagnosis. Four weeks after RT/TMZ, subjects received 5 consecutive daily TMZ doses (150–200 mg/m2) administered every 28 days. BV (10mg/kg) was given every 14 days. Treatment continued until either disease progression or unacceptable toxicity occurred. Results: 42 of 48 planned subjects were enrolled as of 12/30/08. Twenty-three remained on study. Of these, 4 were receiving RT/TMZ, 18 were receiving TMZ/BV and 1 was delayed post-RT/TMZ due to local wound infection. Nineteen were off-study. Eleven of those off-study never received BV due to: study withdrawal (n = 2), toxicity during RT/TMZ (n = 3) and post-RT/TMZ progression (n = 6). Seven subjects progressed while receiving TMZ/BV. Twenty-six of the 42 enrolled received at least one 28-day cycle of TMZ/BV (range 1 - 16 cycles). Duration of treatment, inclusive of RT/TMZ, ranged from 27 to 523 days. Best radiographic responses of evaluable subjects, using MacDonald criteria were: 5 complete, 9 partial, 13 stable and 7 progressive disease. Of those taken off study, 13 were due to disease progression. Of those removed from study due to toxicity, none were unexpected and only 1 (a GI bleed) occurred during the TMZ/BV phase. A statistical analysis of response and survival is pending. Conclusions: The co-administration of TMZ/BV following RT/TMZ for newly diagnosed GBM is safe and well-tolerated. [Table: see text]
Pickles of Wensleydale
Authors: R Moorhead
Journal: Journal of the Royal Society of Medicine (2001)

Will Pickles, who lived from 1885 to 1969, served his patients in Wensleydale, Yorkshire, for more than 50 years. But he also served a wider world. For more than a quarter of a century he carefully recorded observations on infectious disease in the Dale, and is now seen as one of the greatest general practitioners of all time. Pickles showed that the rural general practitioner had opportunities for making observations on disease that were denied to other medical men.
Abstract 10011: Brain Natriuretic Peptide as a Noble Marker of a Salt-sensitivity in Chronic Kidney Disease Patients without Cardiac Dysfunction
Authors: Mutsuharu Hayashi, Yoshinari Yasuda, Hideki Ishii, Daiji Yoshikawa, Toyoaki Murohara
Journal: Circulation (2012)

Background: Though renin-angiotensin system (RAS) is counterbalanced by a salt-sensitivity in hypertensive state, both were reported to be up-regulated in CKD patients. To investigate the interacti...
Abstract 15816: Clinical and Echocardiographic Determinants of N-Terminal Pro B-type Natriuretic Peptide Level in Patients with Stable Chronic Obstructive Airways Disease: A Prospective Observational Study of 140 Patients.
Authors: Christopher P Gale, John E White, Jane Owen, Jane Allen, Josie Watson, Ian Holbrook, Alistair S Hall, Nigel Durham, Ian R Pearson, Maurice A Pye
Journal: Circulation (2010)

Background:  Brain natriuretic peptides have been shown to be reliable indicators of left ventricular failure and markers of risk in cardiac disease. However, patients with chronic obstructive pulmonary disease (COPD) are also known to have elevated concentrations of brain natriuretic peptides in the absence of overt cardiac disease, likely due to right ventricular strain. This has been shown to have prognostic value and has a potential role in the management of the condition; for example, it has been suggested that it could be used to guide the initiation of non-invasive ventilation. The aim of this study was to identify clinical and echocardiographic determinants of the polypeptide N-terminal pro-Brain Natriuretic Peptide (NT pro-BNP) in patients with stable COPD.   Method:  Arterial blood gases, plasma NT pro-BNP and transthoracic echocardiographic parameters were studied in 140 patients with stable COPD attending a respiratory outpatient clinic.   Results:  Of the 140 patients, 65 (46%) were male, 26 (19%) received home oxygen therapy, 115 (82%) were current smokers, 38 (27%) were prescribed diuretics and 15 (11%) had a left ventricular ejection fraction  P  P =0.017) and higher pulmonary artery systolic pressures ( P =0.01). The median (interquartile range) NT pro-BNP concentration was 16.2 (25.4) pmol/L. Concentrations were significantly higher in those with a dilated left atrium, aortic stenosis, left ventricular systolic dysfunction, right ventricular impairment, atrial fibrillation and those prescribed diuretics and ACE inhibitors. Significant predictors of NT pro-BNP were a dilated left atrium, aortic stenosis and left ventricular systolic dysfunction. NT Pro-BNP was an excellent discriminator of RV impairment (C statistic = 0.90).   Conclusions:  NT pro-BNP readily identifies patients with stable COPD who have right ventricular dysfunction. However, several other clinical variables also associated with increased NT pro-BNP concentrations are prevalent in this population. This is likely to confound clinical decision making.
Abstract 19133: Von Willebrand Factor Inhibition Improves Endothelial Function In Patients With Stable Angina
Authors: Olivier Muller, Michalis Hamilos, Jozef Bartunek, Kristof Vercruysse, Christian Duby, William Wijns, Guy R Heyndrickx, Josi B Holz, Emanuele Barbato
Journal: Circulation (2010)

Von Willebrand factor (vWF) is a marker of endothelial dysfunction. Improvement of endothelial function with aggressive medical therapy is associated with significant reduction in vWF levels. ALX-0...
Stable Transduction of the Interleukin-2 Gene Into Human Natural Killer Cell Lines and Their Phenotypic and Functional Characterization In Vitro and In Vivo
Authors: Shigeki Nagashima, Robbie Mailliard, Yoshiro Kashii, Torsten E. Reichert, Ronald B. Herberman, Paul Robbins, Theresa L. Whiteside
Journal: Blood (1998)
Toxicology. The Nature, Effects and Detection of Poisons, with the Diagnosis and Treatment of Poisoning.
Authors: Cassius Marcellus Riley
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Exercise Acutely Exacerbates Derangement Of Cardiac Energy Metabolism In Hypertrophic Cardiomyopathy, a 31 Phosphorus Magnetic Resonance Study at 3 Telsa
Authors: Sairia Dass, Lowri E Cochlin, Joseph J Suttie, Cameron Holloway, Christopher T Rodgers, Damian Tyler, Theodoros D Karamitsos, Kieran Clarke, Hugh Watkins, Stefan Neubauer
Journal: Circulation (2011)

Introduction: Hypertrophic cardiomyopathy (HCM) affects up to 1 in 500 of the population and is the commonest cause of sudden death in the younger population. However, its pathophysiology and mecha...
NICE’s simplified approach can’t not work
Authors: Magnus I Hird
Journal: BMJ (2008)

Vitamin D deficiency is widespread in Scotland I agree with Holick 1 and Sievenpiper et al 2 about the urgent need to highlight the neglected subject of vitamin D deficiency in the United Kingdom.We have found in our general practice in Edinburgh a (to us) surprisingly high prevalence of gross vitamin D deficiency.The deficiency affects not only our South Asian patients but also a considerable number of those with white skin colour.Between 2005 and 2007, blood samples were taken from 99 patients aged 15-85.We included patients suspected of having a possible vitamin D deficiency: patients of South Asian origin or other ethnic minorities, patients with vague musculoskeletal symptoms or overweight, patients taking antiepileptic drugs, patients using sunscreen or make up, housebound patients, and patients with little exposure to sunlight.The figure shows our as yet unpublished results.According to the definitions of most vitamin D researchers, insufficient vitamin D concentrations are those below 75 nmol/l.In our sample only 2% had a sufficient vitamin D concentration.Measurements below 25 nmol/l are defined as severe deficiency; in our sample, the proportion was 47%.We select the letters for these pages from the rapid responses posted on bmj.com favouring those received within five days of publication of the article to which they refer.Letters are thus an early selection of rapid responses on a particular topic.
Abstract 4175: Duration of Acute Kidney Injury and Long-term Survival Following Cardiac Surgery
Authors: Jeremiah R Brown, Robert S Kramer, Steven G Coca, Chirag R Parikh
Journal: Circulation (2009)

Background: Acute kidney injury (AKI) following cardiac surgery is associated with worse complications. However, it is not known how adverse long-term consequences vary according to the duration of AKI. We hypothesized that longer durations of AKI are associated with an increased risk of long-term mortality compared with short episodes of AKI independent of AKI.  Methods: We prospectively enrolled 4,987 cardiac surgery patients from 2002 through 2007 with serum creatinine (SCr) collection at a medical center in northern New England. Patients with dialysis were excluded (N=70). AKI was defined as a ≥0.3 (mg/dL) or ≥50% increase in SCr from baseline. Duration of AKI was defined by the number of days AKI was present and categorized by: no AKI, AKI for 1–2, 3– 6 and ≥7 days. Univariate and multivariate regression, Kaplan Meier, and Cox’s proportional hazard modeling were conducted to evaluate long-term mortality.  Results: 39% of patients developed AKI. Long-term mortality was significantly different at 5 years by AKI duration (p  Conclusions: The duration of AKI after cardiac surgery is directly proportional to long-term mortality and has important implications in patient care and can aid clinicians in evaluating the risk of in-hospital and post-discharge death.
Identification and characterization of a novel proteasome inhibitor with apoptotic properties in neuroblastoma
Authors: Andre Bachmann, Crystal Archer, Barbara Schellenberg, Markus Kaiser, Michael Groll, Robert Dudler
Journal: Cancer Research (2008)

AACR Annual Meeting-- Apr 12-16, 2008; San Diego, CA

3258 

Pathogenic bacteria often use effector molecules to increase virulence. In most cases, the mode of action of effectors remains unknown. In this work, we identified a novel molecule (SylA) produced by a plant pathogen that acts as a virulence factor and inhibits all three catalytic activities of the eukaryotic proteasome ( in vitro and in vivo ), thus adding proteasome inhibition to the repertoire of modes of action of virulence factors. Co-crystallization of SylA with the yeast proteasome revealed a novel mechanism of covalent binding to the catalytic subunits. Our data further show that SylA modulates the protein signaling network of neuroblastoma cells and induces apoptosis. Proteasome inhibitors are a promising new class of anti-cancer drugs as evidenced by bortezomib, a FDA-approved drug for the treatment of multiple myeloma. Intriguingly, SylA is a natural product molecule with unique structural features that irreversibly inhibits proteasomal activity by a novel mechanism, thus representing a new structural class of proteasome inhibitors with great potential for further development into an effective anti-cancer drug.
The Micellar Sink
Authors: Bruce F. Scharschmidt, Rudi Schmid
Journal: Journal of Clinical Investigation (1978)

Although the importance of mixed micelles in the solubilization and biliary excretion of lipids is established, little is known about a possible role of mixed micelles in the excretion of other biliary solutes. Ultrafiltration and ultracentrifugation techniques were used to investigate the interaction between substances that are excreted in bile and biliary mixed micelles. Substances (urea, erythritol, sucrose) excreted in bile at concentrations equal to, or less than, that in plasma did not show an association with mixed micelles, whereas substances (indocyanine green, iopanoic acid, rose bengal, unconjugated and conjugated sulfobromophthalein, and conjugated bilirubin) excreted in bile at high concentration relative to plasma did. The percentage of these latter substances in bile associated with micelles varied from 26 to 93% and was relatively independent of concentration. In addition to their association with mixed micelles, these test solutes formed self-aggregates that were stabilized primarily by ionic bonds, and only a small percentage (range = 0-5%) of these solutes were present in bile in the form of monomer or complexes small enough to pass a 5,000-mol wt membrane.
Abstract 17429: The Usefulness of Ultrasound Lung Comets Evaluated by Using the Newly-Developed Pocket-Sized Transthoracic Echocardiographic Imaging Device in Patients with Suspected Heart Failure
Authors: Hiroki Oe, Rika Takemoto, Norihisa Toh, Satoko Ugawa, Yuko Ono, Nobuhisa Watanabe, Yasuharu Tanabe, Kazufumi Nakamura, Hiroshi Morita, Kunihisa Kohno, Kengo Kusano, Hiroshi Ito
Journal: Circulation (2012)

Background Ultrasound lung comets (ULCs) assessment is simple, fast and clinically useful for the evaluation of pulmonary congestion in patients with heart failure (HF). The aim of this study is to...
Practical Clinical Hematology. Interpretations and Techniques.
Authors: Paul L. Wolf
Journal: Annals of Internal Medicine (1975)

Book reviews literature dealing with those manifesta- tions of the spread of human tumours which are to be observed by clinician and pathologist.It is a curious mixture con- sisting of catalogues of secondary tumours in various sites, little clinical asides, interesting short scientific essays based on his wide experience and reading, anecdotes, and of course a hobbyhorse or two-mesothelioma, Ewing's sarcoma, and details of all-but-forgotten polemics.
PROGRESS IN DENTAL EDUCATION
Authors: Frederick C. Waite
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal