tbuckley/cabot-search huggingface dataset:
Coronary intervention in patients with intermediate stenoses can be deferred on the basis of negative dobutamine stress echocardiography Tom Giesler, Uwe Nixdorff, Susanne Lamprecht, Dieter Ropers, Martin Br�ck, Jens U. Voigt, Joseph Ludwig, Werner G. Daniel. University of Erlangen-Nuremberg, Department of Internal Medicine II, Erlangen, Germany
Journal: Journal of the American College of Cardiology (2001)
Sustainable Technology for Adolescents and youth to Reduce Stress (<scp>STARS</scp>): a <scp>WHO</scp> transdiagnostic chatbot for distressed youth
Authors: Jennifer Hall, Stewart Jordan, Mark van Ommeren, Teresa Au, Rajiah Abu Sway, Joy Crawford, Heba Ghalayani, Syed Usman Hamdani, Nagendra P. Luitel, Aiysha Malik, Chiara Servili, Katherine Sorsdahl, Sarah Watts, Kenneth Carswell
Journal: World Psychiatry (2022)
Nanocarriers for pancreatic cancer imaging, treatments, and immunotherapies
Authors: Luman Liu, Prakash G. Kshirsagar, Shailendra K. Gautam, Mansi Gulati, Emad I. Wafa, John C. Christiansen, Brianna M. White, Surya K. Mallapragada, Michael J. Wannemuehler, Sushil Kumar, Joyce C. Solheim, Surinder K. Batra, Aliasger K. Salem, Balaji Narasimhan, Maneesh Jain
Journal: Theranostics (2022)

Pancreatic tumors are highly desmoplastic and immunosuppressive. Delivery and distribution of drugs within pancreatic tumors are compromised due to intrinsic physical and biochemical stresses that lead to increased interstitial fluid pressure, vascular compression, and hypoxia. Immunotherapy-based approaches, including therapeutic vaccines, immune checkpoint inhibition, CAR-T cell therapy, and adoptive T cell therapies, are challenged by an immunosuppressive tumor microenvironment. Together, extensive fibrosis and immunosuppression present major challenges to developing treatments for pancreatic cancer. In this context, nanoparticles have been extensively studied as delivery platforms and adjuvants for cancer and other disease therapies. Recent advances in nanotechnology have led to the development of multiple nanocarrier-based formulations that not only improve drug delivery but also enhance immunotherapy-based approaches for pancreatic cancer. This review discusses and critically analyzes the novel nanoscale strategies that have been used for drug delivery and immunomodulation to improve treatment efficacy, including newly emerging immunotherapy-based approaches. This review also presents important perspectives on future research directions that will guide the rational design of novel and robust nanoscale platforms to treat pancreatic tumors, particularly with respect to targeted therapies and immunotherapies. These insights will inform the next generation of clinical treatments to help patients manage this debilitating disease and enhance survival rates.
Maternal Contraceptive Use and Central Nervous System Tumors in Offspring
Authors: Logan G. Spector, Christopher L. Moertel, H. Irene Su
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Agricultural Genome to Phenome Initiative (AG2PI): creating a shared vision across crop and livestock research communities
Authors: Christopher K. Tuggle, Jennifer Clarke, Jack C. M. Dekkers, David Ertl, Carolyn J. Lawrence-Dill, Eric Lyons, Brenda M. Murdoch, Nicole M. Scott, Patrick S. Schnable
Journal: Genome biology (2022)

Predicting phenotype from genotype is a central challenge in biology.By understanding genomic information to predict and improve traits, scientists can address the challenges and opportunities of achieving sustainable genetic improvement of complex, economically important traits in agriculturally relevant species.Converting the enormous, recent technical advances in all areas of genomics and phenomics into sustained and ecologically responsible improvements in food and fuel production is complex.It will require engaging agricultural genome to phenome (G2P) experts, drawing from a broad community, including crop and livestock scientists and essential integrative disciplines (e.g., engineers, economists, data and social scientists).To achieve this vision, the USDA NIFA-funded project inaugurating the Agricultural Genome to Phenome Initiative (AG2PI) is working to: Develop a cohesive vision for agricultural G2P research by identifying research gaps and opportunities; advancing community solutions to these challenges and gaps; and rapidly disseminating findings to the broader community.Towards these ends, this AG2PI project is organizing virtual field days, conferences, training workshops, and awarding seed grants to conceive new insights (details at www.ag2pi.org).Since October 2020, more than 10,000 unique participants from every inhabited continent have engaged in these activities.To illustrate AG2PI's scope, we present survey results on agricultural G2P research needs and opportunities, highlighting opinions and suggestions for the future.We invite stakeholders interested in this complex but critical effort to help create an optimal, sustainable food supply for society and challenge the community to add to our vision for future accomplishments by a fully actualized AG2PI enterprise. Differences hinder global advancements to sustainable food productionTo meet the challenges and overcome the environmental stressors of agricultural production for an increasing global population, we must understand better how genotype begets phenotype and how the interactions of genotype and the environment influence
OA06.04 Postoperative Chemotherapy Use and Outcomes from ADAURA: Osimertinib as Adjuvant Therapy for Resected EGFR Mutated NSCLC
Authors: Y. Wu, T. John, C. Grohe, M. Majem, J. Goldman, S. Kim, T. Kato, K.K. Laktionov, H.V. Vu, Z. Wang, S. Lu, K.Y. Lee, C. Akewanlop, C. Yu, F. De Marinis, L. Bonanno, M. Domine, F. Shepherd, L. Zeng, A. Atasoy, R. Herbst, M. Tsuboi
Journal: Journal of Thoracic Oncology (2021)
Greenhill's Surgical Gynecology
Authors: John W. Huffman
Journal: JAMA (1987)

The authors have rightly acknowledged Dr Greenhill's contribution to gynecologic surgery. He had a major influence, through his writings on gynecology, during the formative years of the specialty in this country. The book is a relatively small but concise text. Its most notable features are the chapters that describe the gynecologic surgeon's equipment and methods, fluid and electrolyte metabolism, and preoperative and postoperative patient care. Five of the ten chapters are devoted to illustrations of various minor and major operative procedures. The line drawings are much like those that have appeared in gynecologic texts for many years; a number of them lack the detail necessary for a clear understanding of the operation. In the preface, the authors state that the book is intended primarily for the neophyte in the specialty. It fulfills this aim in that it shows stereotyped steps in most procedures that an intern will see gynecologic surgeons
MetAP2 Inhibition Modifies Hemoglobin S (HbS) to Delay Polymerization and Improve Blood Flow in Sickle Cell Disease
Authors: Melanie Demers, Sarah Sturtevant, Kevin Guertin, Dipti Gupta, Kunal Desai, Benjamin Vieira, Alexandra Hicks, Ayman Ismail, Yukio Nakamura, Bronner Goncalves, Giuseppe Di Caprio, Ethan Schonbrun, Scott Hansen, Martin K. Safo, David K. Wood, John M. Higgins, David R. Light
Journal: Blood (2019)
THE OMISSION OF DRAINAGE FOLLOWING CHOLECYSTECTOMY
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Decreased contractile reserve in severe aortic insufficiency using MRI-derived stress and strain relationships Giridhar Vedala, Pavlos Moustakidis, Randall P. Scheri, Brian P. Cupps, Robert J. Gropler, Nancy J. Nickerson, Nicholas T. Kouchoukos, Michael K. Pasque, Victor G. Davila-Roman. Washington University School of Medicine, St. Louis, MO
Journal: Journal of the American College of Cardiology (2001)
Abstract 17215: Pacing Burden in Those Undergoing Permanent Pacemaker Implantation After TAVR With Latest Generation Valves
Authors: Amneet Sandhu, Karen Ream, Wendy Tzou, Alexis Tumolo, Blake Fleeman, Nicholas Mantini, Duy T Nguyen, William H Sauer, Ryan G Aleong
Journal: Circulation (2018)

Background: Risk factors leading to heart block (HB) and need for permanent pacemaker (PPM) implantation post-TAVR using latest generation heart valves have been described. Yet, little is known regarding pacing burden following PPM implantation among such patients. Objective: We sought to determine follow-up RV pacing burden among those undergoing PPM for HB following TAVR. Methods: From July 2016 to July 2017, we reviewed procedural and 3-month follow-up data (including PPM interrogation data) from all patients undergoing implantation of Edwards Sapien 3® and Medtronic Evolut-R® valves at our institution and requiring implantation of a PPM due to HB secondary to the TAVR procedure. Results: Of 132 included patients who underwent TAVR with new generation valves, 25 (19%) required post-TAVR PPM implantation. Of 25 patients, 18 had available follow-up pacemaker data [Table]. Pacing burden post-PPM implantation of 29mm valves was significantly greater compared to non-29mm valves (40.2% vs. 5.4%, p = 0.02). Those with baseline conduction system disease (RBBB or LBBB) had greater pacing burdens, in particular when 29mm Evolut-R® self-expanding valves were deployed (n=3, RV pacing burden 63.3%). Extension of programmed AV delays produced significant reduction in RV pacing burden. Conclusion: In those undergoing TAVR with latest generation valves complicated by HB requiring PPM use, implantation of larger-sized valves (29 mm Evolut-R® in the present series), as well as baseline RBBB or LBBB results in increased follow-up RV pacing burden. This may be mitigated by adjustment of pacing parameters. Further work investigating long-term pacing burden and its consequences is needed to provide additional insight. Table: Demographics, baseline ECG characteristics, procedural characteristics, pacing mode, pacing parameters and follow-up RV pacing burden.
Abstract P094: Sex Differences in Fitness Outcomes After Participation in a Park-Based After school Program Among Minority Youth
Authors: Sarah E Messiah, Emily M D'Agostino, Hersila H Patel, Eric Hansen, M. Sunil Mathew, Deidre Okeke, Maria Nardi
Journal: Circulation (2018)

Introduction: Only 18% of high school girls compared with 37% of boys are reported to meet national physical activity guidelines, but much less is known about sex differences in fitness levels during the elementary and middle school years. This study aimed to describe sex differences in longitudinal fitness outcomes after participation in Fit2Play TM , a park-based afterschool health and wellness program targeting high risk youth ages 6-to-14 years old. Hypothesis: It was hypothesized that over time boys would have more improvement in (1) cardiorespiratory fitness via the Progressive Aerobic Cardiovascular Endurance Run (PACER) and 400 meter run test; (2) strength via 1-minute timed push-ups and sit-ups; and (3) flexibility via the sit-and-reach test, versus girls. Methods: Youth who participated in Fit2Play TM for either 1, 2 or 3 school years between 2010-2016 (N=2129, mean age 9.1 years, 52% Hispanic, 48% non-Hispanic black, 54% male) participated in a fitness battery at the beginning and end of the school year(s). Effects of length of Fit2Play TM participation on fitness outcomes were assessed via 3-level repeated measures analysis stratified by sex and adjusted for child sociodemographics, weight category, area poverty, and year. Results: Adjusted models showed significant improvements for both boys and girls in the PACER and 400 meter run tests (p&lt;0.001 for both), with greater magnitude of effects and dose-response trends for girls after up to 3 years of participation in Fit2Play TM . Specifically, from baseline to 1, 2 and 3 years of program participation, girls demonstrated 8% (95% CI: 0.87, 0.97), 14% (95% CI: 0.77, 0.96), and 23% (95% CI: 0.65, 0.92) mean improvement in 400 meter run times versus 9% (95% CI: 0.86, 0.96), 9% (95% CI: 0.82, 1.01), and 17% (95% CI: 0.70, 0.98) for boys, respectively (p&lt;0.001 for all). Significant strength improvements were found for both boys and girls for push-ups (p&lt;.01 for both, though 4%, 11% and 12% higher magnitude of effects in girls vs. boys for 1, 2 and 3 years of participation, respectively), and only girls for sit-ups (p&lt;.001). Conclusions: Park-based afterschool physical activity programs have the potential to improve fitness performance in all youth, and particularly girls. Future research should further examine sex differences in the effects of park and other community based programs to ultimately reduce sex disparities in youth fitness, particularly in light of the current youth obesity epidemic that continues to challenge our nation.
Mismatch repair proteins (MMR) expression as predictive factor in locally advanced rectal cancer.
Authors: Andrea Pretta, Clelia Donisi, Mara Persano, Giovanna Pinna, Erika Cimbro, Alissa Parrino, Valentina Aimola, Dario Spanu, Giulia Cerrone, Simona Deidda, Maria Assunta Deidda, Eleonora Lai, Valeria Pusceddu, Marco Puzzoni, Pina Ziranu, Raffaele Barbara, Angelo Restivo, Luigi Zorcolo, Gavino Faa, Mario Scartozzi
Journal: Journal of Clinical Oncology (2022)

182 Background: Only few data on microsatellite instability in rectal cancer are available in literature, and dMMR role in pre-operative chemoradiotherapy response is under debate. The aim of our study was to evaluate the frequency and therapeutic implications of dMMR status in patients (pts) with locally advanced rectal cancer belonging to our Center. Methods: Data were retrospectively collected from 231 patients belonging to the Medical Oncology Unit of the University Hospital of Cagliari from 2011 to 2021. All patients were affected by locally advanced rectal adenocarcinoma (cT3-4 +/- N1-2). All patients included in the study underwent neoadjuvant chemoradiotherapy treatment with capecitabine and RT long course (total dose of Gy 50.4) and subsequently underwent total mesorectal excision (TME) followed by adjuvant chemotherapy. Mismatch repair (MMR) expression was evaluated through immunohistochemistry on surgical samples. Results: Of the 231 patients, 213 were suitable for final analyzes. Patients median age was 68 years (range 34-89). 145/201 were male and 68 were female. 66 (31%) had stage II disease and 147 (69%) had stage III disease. Considering MMR, 205/213 (96%) patients had proficient mismatch repair (pMMR), while 8/213 (4%) had dMMR. In dMMR patients defective proteins were: MSH2 in 4 patients, MLH1 and PMS2 combined in 2 patients and MSH6 in 2 patient. dMMR patients showed, unlike pMMR patients, poor or no response to chemoradiotherapy. Responses were assessed through TRG evaluation (Ryan and Dworak scoring systems) on the primary tumour. 5 patients presented a TRG-3 and 3 patients showed a TRG-4, according to Ryan score. All of them had a grade 1 regression, according to Dworak. Conclusions: The results of our study, albeit with limitations related to the retrospective nature and the limited number of dMMR cases, might indicate a correlation between microsatellite instability and little or no response to preoperative chemo-radiotherapy. It would be useful to analyze the data prospectively and further evaluate MMR as a predictor of response to combined chemo-radiotherapy.[Table: see text]
Error in Results, Figures, and Tables
Authors: David Miklowitz, Toshi Furukawa, Andrea Cipriani, David Geffen
Journal: JAMA Psychiatry (2021)

Benjamin I. Perry, MRCPsych; Jan Stochl, PhD; Rachel Upthegrove, PhD; Stan Zammit, PhD; Nick Wareham, PhD; Claudia Langenberg, PhD; Eleanor Winpenny, PhD; David Dunger, PhD; Peter B. Jones, PhD; Golam M. Khandaker, PhD
DIABETES AS A MANIFOLD DISEASE.MEDICAL NEWS.
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Workshop on Cloning Human Tumor Stem Cells
Journal: JNCI Journal of the National Cancer Institute (1978)

Workshop on Cloning Human Tumor Stem Cells JNCI: Journal of the National Cancer Institute, Volume 61, Issue 4, October 1978, Page 1175, https://doi.org/10.1093/jnci/61.4.1175 Published: 01 October 1978
Abstract P108: Race and Socioeconomic Status Are Strongly Associated With Racial Disparities in Cardiovascular Health and Outcomes in Chicago
Authors: Claudia D Ofori-Marfoh, Caroline Volgman, Annabelle Volgman, Sarah Alexander, Kim Williams
Journal: Circulation (2018)

Introduction: Cardiovascular (CV) disease (CVD) is the leading cause of mortality in Chicago according to the most recent data gathered by the Chicago Department of Public Health (DPH). This is also true at the state and national level. The unique distribution of the population in Chicago along racial/ethnic lines promotes disparity in CVD prevalence and, consequently, higher mortality in certain racial minorities and neighborhoods. We sought to identify the factors contributing to racial disparities in CV health, interventions that have been initiated to address these risk factors and lastly, solutions to decrease this gap in Chicago. Hypothesis: We hypothesize that unique risk factors put certain racial minorities, especially African Americans (AAs), at greater risk for CVD and mortality. Methods: An extensive literature search was performed using PubMed, Scopus and the Chicago DPH Epidemiological database with the search terms/phrases health disparities, CVD, mortality, longevity, life expectancy and Chicago in order to identify contributing factors to racial disparities in CV health and outcomes in Chicago. Results: Many CV risk factors identified at the national level held true for Chicago. Race and socioeconomic status (SES) were repeatedly found to be significantly associated with increased prevalence of CV risk factors with one study finding no association between residence in a primary care health provider-deprived area and increased prevalence of CV risk factors after adjusting for SES and race. AAs, persisting into old age, had poorer control of hypertension (45% vs 51%, p &lt;0.001) relative to their Non-Hispanic White counterparts regardless of their Medicare eligibility status and after adjusting for potential confounders such as SES and obesity. Life expectancy for AA Chicagoans was the lowest at 71.7 with Hispanics having the highest life expectancy at 84.6, and Non-Hispanic Whites at 78.8 years. CVD claims the most lives in Chicago with AAs at greatest risk for CV mortality greatly contributing to longevity being the lowest in this racial subgroup. Interventions identified include city-level efforts such as the Healthy Chicago 2.0 initiative and partnerships involving public, community and healthcare organizations striving to narrow the health disparities gap. Recognition that race and SES are strongly associated with adverse CV health outcomes to a greater extent in certain racial subgroups is a huge step in increasing effective strategies to combat the disproportionate burden of CVD in this subgroup. Conclusion: African Americans in Chicago suffer the greatest burden of CVD and mortality with studies strongly suggesting that race, itself, and SES are leading culprits in this racial disparity.
Weighted numbers
Authors: Mila Marinova, Marta Fedele, Bert Reynvoet
Journal: Behavioral and Brain Sciences (2021)

Abstract Clarke and Beck (C&amp;B) discuss in their sections on congruency and confounds (sects. 3 and 4) literature that has challenged the claim that the approximate number system (ANS) represents numerical content. We argue that the propositions put forward by these studies aren't that far from the indirect model of number perception suggested by C&amp;B.
Temporomandibular Joint—Pain and Dysfunction Course
Journal: JNCI Journal of the National Cancer Institute (1982)

Temporomandibular Joint—Pain and Dysfunction Course JNCI: Journal of the National Cancer Institute, Volume 69, Issue 2, August 1982, Page 547, https://doi.org/10.1093/jnci/69.2.547-a Published: 01 August 1982