tbuckley/cabot-search huggingface dataset:
SAT0020 Serum nitric oxide, catalase, superoxide dismutase, xantine oxidase and malandialdehyde status in patients with ankylosing spondylitis
Authors: S Ozgocmen, O Ardicoglu, S Sogut, I Pekkutucu, E Fadillioglu, O Akyol
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> <h3>Objectives</h3> In this study serum antioxidant and oxygen derived free radical status of patients with ankylosing spondylitis (AS) has been investigated and compared with age and sex matched healthy controls. <h3>Methods</h3> Thirty patients fulfilling the New York criteria for AS and age and sex matched 16 healthy control subjects were included in the study. Patients who were smoking, under the treatment of DMARDs or any other drugs (except NSAIDs informally used by the patients) excluded. Catalase (CAT) (EC 1.11.1.6) activity was measured by the determination of rate constant of hydrogen peroxide decomposition. Total (Cu-Zn and Mn) SOD (EC 1.15.1.1) activity was determined by the method based on the inhibition of NBT reduction by the xanthine-xanthine oxidase system. Malandialdehyde (MDA) levels determination was based on the coupling of MDA with thiobarbituric acid (TBA) at +95 ºC. XO (EC 1.2.3.2) activity was measured spectrophotometrically by the formation of uric acid from xanthine through the increase in absorbency at 293 nm. Nitrite (NO2-) and nitrate (NO3-) were estimated as an index of NO production. Quantitation of nitrate and nitrite was based on the Griess reaction, in which a chromophore with a strong absorbency at 540 nm is formed by reaction of nitrite with a mixture of naphthlethylenediamine and sulphanilamide. <h3>Results</h3> Patients had significantly higher MDA and CAT activity with respect to controls. CAT activity of patients correlated significantly with CRP and ESR levels. <h3>Conclusion</h3> Our results indicate that MDA and CAT activity increase in patients with AS, and CAT activity may be related to disease activity.
Bladder Tumor Subtype Commitment Occurs in Carcinoma <i>In Situ</i> Driven by Key Signaling Pathways Including ECM Remodeling
Authors: Adrian Wullweber, Reiner Strick, Fabienne Lange, Danijel Sikic, Helge Taubert, Sven Wach, Bernd Wullich, Simone Bertz, Veronika Weyerer, Robert Stoehr, Johannes Breyer, Maximilian Burger, Arndt Hartmann, Pamela L. Strissel, Markus Eckstein
Journal: Cancer Research (2021)

Basal and luminal subtypes of invasive bladder tumors have significant prognostic and predictive impacts for patients. However, it remains unclear whether tumor subtype commitment occurs in noninvasive urothelial lesions or in carcinoma in situ (CIS) and which gene pathways are important for bladder tumor progression. To understand the timing of this commitment, we used gene expression and protein analysis to create a global overview of 36 separate tissues excised from a whole bladder encompassing urothelium, noninvasive urothelial lesions, CIS, and invasive carcinomas. Additionally investigated were matched CIS, noninvasive urothelial lesions, and muscle-invasive bladder cancers (MIBC) from 22 patients. The final stage of subtype commitment to either a luminal or basal MIBC occurred at the CIS transition. For all tissues combined, hierarchical clustering of subtype gene expression revealed three subtypes: "luminal," "basal," and a "luminal p53-/extracellular matrix (ECM)-like" phenotype of ECM-related genes enriched in tumor-associated urothelium, noninvasive urothelial lesions, and CIS, but rarely invasive, carcinomas. A separate cohort of normal urothelium from noncancer patients showed significantly lower expression of ECM-related genes compared with tumor-associated urothelium, noninvasive urothelial lesions, and CIS. A PanCancer Progression Panel of 681 genes unveiled pathways specific for the luminal p53-/ECM-like cluster, for example, ECM remodeling, angiogenesis, epithelial-to-mesenchymal transition, cellular discohesion, cell motility involved in tumor progression, and cell proliferation and oncogenic ERBB2/ERBB3 signaling for invasive carcinomas. In conclusion, this study provides insights into bladder cancer subtype commitment and associated signaling pathways, which could help predict therapy response and enhance our understanding of therapy resistance. SIGNIFICANCE: This study demonstrates that CIS is the stage of commitment for determining MIBC tumor subtype, which is relevant for patient prognosis and therapy response.
FRI0017 Infliximab (anti-tnf alpha antibody) treatment for rheumatoid arthritis: interim analysis of a spanish cohort study performed in routine practice. a multicenter open-label study of the catalonian society of rhematology, catalunya, spain
Authors: J Carbonell
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> <h3>Objectives</h3> To evaluate the efficacy and safety of infliximab for RA in daily clinical practice. <h3>Methods</h3> We included 54 patients with refractory RA who failed at least two different DMARDs (including MTX). The patients received 3 mg/kg infliximab at weeks 0, 2, 6 and the every 8 weeks for 54 weeks. MTX and all other concomitant medications were kept at a stable during the study. Evaluations before each infusion included tender (TJC) and swollen joint counts (SJC), patient and physician global assessments, pain score (VAS), HAQ, morning stiffness, and ESR. All adverse events were recorded. We used the Wilcoxon test for two related samples to assess differences between measures taken in pairs. <h3>Results</h3> All patients received at least 2 infusions and 9 patients completed the study through week 22, when this analysis was done. ACR components including TJC, SJC, morning stiffness, patient and physician global assessments, VAS pain, ESR and the HAQ significantly decreased at week 2 (with p &lt; 0,001 for all these ACR components), as it is shown in Table 1. At week 6, all these ACR components showed values significantly decreased (p &lt; 0,001) with relation to week 0 but not in comparison with week 2 (except for TJC, SJC and physician global assessment with p &lt; 0,01). The results for clinical response and HAQ did not reach statistical significance after week 6, due to the small number of patients that completed treatment in week 14 (n = 24) and in week 22 (n = 9). One patient dropped out because of major surgery (related to the RA). The treatment was well tolerated; only minor adverse events (n = 15) without any serious infection were noted. <h3>Conclusion</h3> Patients with refractory rheumatoid arthritis significantly improve during therapy with infliximab. The observed beneficial effect is maintained during the treatment period without major adverse events.
Feasibility of using a computerized food frequency questionnaire (FFQ) to assess dietary patterns in patients with advanced gastrointestinal (GI) malignancies.
Authors: Rishi Jain, Crystal S. Denlinger, Elizabeth A. Handorf, Roshan George, Bianca Lewis, Alexandra Hunt, Kara Stromberg, Igor A. Astsaturov, Efrat Dotan, Michael J. Hall, Namrata Vijayvergia, Carolyn Y Fang
Journal: Journal of Clinical Oncology (2021)

465 Background: Identification of poor dietary patterns is important for the optimal management of patients with metastatic GI malignancies who suffer from high rates of malnutrition and sarcopenia which are associated with increased rates of treatment-related toxicity and worsened survival. Dietary records or recall methods and FFQs are available but have high patient burden and are seldom utilized in oncology settings outside of formal nutritional consultations. Thus, we evaluated the feasibility of conducting serial assessments of dietary patterns using a novel computerized FFQ technology. Methods: Assessments of diet using the computerized FFQ, nutritional status (NUTRISCORE), QOL and anorexia/cachexia burden (FAACT), anxiety/depression (HADS) and taste burden were done at the time of initiation of first-line chemotherapy (baseline) and 3 months later. The FFQ was done independently either at home on personal computer after visit or via iPad in infusion room. Dietary quality was defined by the Healthy Eating Index 2010 (HEI) score, which was automatically calculated by the computerized FFQ software. Feasibility was defined as at least 70% of patients completing baseline and 3-month assessments. Spearman’s correlations were used to determine associations between measures. Results: 29 patients with advanced (metastatic or unresectable) GI cancers were enrolled and 23 completed the baseline FFQ (8 colorectal, 5 pancreas, 5 gastroesophageal, 5 other). Median age was 58 (20-78) with M:F ratio of 10:13. The overall completion rate of baseline and 3-month assessments was 81.8%, meeting the pre-defined feasibility criteria. The mean baseline HEI score was 65 (range 38-88). Of patients who completed both baseline and 3-month assessments, the mean HEI score remained stable at 58 with changes in specific HEI components including a 20% decline in the seafood and plant protein score and a 13% decline in the whole grain score and small improvements in other areas (e.g. empty calories, dairy). There were no significant correlations between baseline HEI score and other assessments. Conclusions: It is feasible to use a computerized FFQ to assess for longitudinal changes in eating patterns and dietary quality in patients with advanced GI cancers, particularly when patients can complete the assessments during chemotherapy infusions. Preliminary findings also suggest that the FFQ can be helpful for highlighting areas in which diet quality could be improved. Additional analysis of other computerized FFQ data (e.g. macro/micronutrient consumption) is ongoing.
Durable clinical benefit following several sirolimuseluting stenting on the outcome of patients with unprotected left main coronary arteries : multicenter registry 2-year results
Authors: S Nakamura, Jang-Ho Bae, Cahyadi Yeo Hans, Udayachalerm Wasan, Tresukosol Damras, Tansuphaswadikul Sudaratana
Journal: Circulation (2006)
Large iatrogenic sigmoid colon perforation treated with endoloop-assisted clip closure and over-the-scope clip: a case report
Authors: Salvatore Russo, Giuseppe Grande, Raffaele Manta, Santi Mangiafico, Helga Bertani, Flavia Pigò, Rita Conigliaro
Journal: Endoscopy (2021)

A 77-year-old woman was admitted to our Emergency Department for an iatrogenic sigmoid colon perforation that occurred during a diagnostic colonoscopy. The patient complained of moderate abdominal pain without signs of peritonitis. Considering the time since colonoscopy (< 2 hours) and the excellent bowel preparation, an attempt was made to treat the perforation endoscopically. Therapeutic colonoscopy was performed under monitored anesthesia care using a single-channel therapeutic gastroscope (EG-3490K; Pentax Medical, Tokyo, Japan) and CO2 insufflation. A 6-cm large full-thickness wall defect at 25 cm from the anal verge, with active oozing bleeding, was detected ([Fig. 1]). Bleeding was controlled with 1:10 000 adrenaline injection; thereafter an endoloop-assisted clip closure was performed.
Lipid-induced endothelial vascular cell adhesion molecule 1 promotes nonalcoholic steatohepatitis pathogenesis
Authors: Kunimaro Furuta, Qianqian Guo, Kevin D. Pavelko, Jeong-Heon Lee, Keith D. Robertson, Yasuhiko Nakao, Jan Melek, Vijay H. Shah, Petra Hirsova, Samar H. Ibrahim
Journal: Journal of Clinical Investigation (2021)

Monocyte homing to the liver and adhesion to the liver sinusoidal endothelial cells (LSECs) are key elements in nonalcoholic steatohepatitis (NASH) pathogenesis. We reported previously that VCAM-1 mediates monocyte adhesion to LSECs. However, the pathogenic role of VCAM-1 in NASH is unclear. Herein, we report that VCAM-1 was a top upregulated adhesion molecule in the NASH mouse liver transcriptome. Open chromatin landscape profiling combined with genome-wide transcriptome analysis showed robust transcriptional upregulation of LSEC VCAM-1 in murine NASH. Moreover, LSEC VCAM-1 expression was significantly increased in human NASH. LSEC VCAM-1 expression was upregulated by palmitate treatment in vitro and reduced with inhibition of the mitogen-activated protein 3 kinase (MAP3K) mixed lineage kinase 3 (MLK3). Likewise, LSEC VCAM-1 expression was reduced in the Mlk3-/- mice with diet-induced NASH. Furthermore, VCAM-1 neutralizing Ab or pharmacological inhibition attenuated diet-induced NASH in mice, mainly via reducing the proinflammatory monocyte hepatic population as examined by mass cytometry by time of flight (CyTOF). Moreover, endothelium-specific Vcam1 knockout mice were also protected against NASH. In summary, lipotoxic stress enhances the expression of LSEC VCAM-1, in part, through MLK3 signaling. Inhibition of VCAM-1 was salutary in murine NASH and might serve as a potential therapeutic strategy for human NASH.
SAT0110 Soluble adhesion molecules (icam-1, vcam-1, e-selectin, p-selectin) in juvenile idiopathic arthritis and childhood – onset scleroderma
Authors: EK Musiej-Nowakowska, J Sopata, J Wize, E Wojtecka-Lukasik, A Romicka, S Maslinski
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> The soluble forms of adhesion molecules (sAM) may have a regulatory function in inflammatory responses and may serve as useful markers of both leukocyte and endothelial cells activation in different diseases, including several autoimmune disorders. They have been studied in adults with certain rheumatic diseases while studies in paediatric patients are more limited. <h3>Objectives</h3> The aim of this study was to compare the levels of sAM in children with juvenile idiopathic arthritis (JIA) and scleroderma and to correlate serum levels of these molecules with conventional inflammatory parameters and to determine differences in these levels among clinical subtypes of JIA. <h3>Methods</h3> Soluble forms of AM ICAM-1, VCAM-1, E-selectin and P-selectin were measured by sandwich ELISA in 47 children with JIA, (24 pauciarticular, 7 polyarticular, 16 systemic) and 11 patients with scleroderma. The levels of sAM according to type of disease, JIA type and some inflammatory parameters (ESR, total white blood cell count-WBC, platelet count) were analysed. <h3>Results</h3> Differences in serum levels of sAM have been demonstrated among the 3 subtypes of JIA. The highest values were seen in patients with systemic disease, lower values in patients with polyarthritis and pauciarticular form. The statistically significant higher levels of sICAM-1 (p &lt; 0.01) and sE-selectin (p &lt; 0.05) were recorded only in JIA patients with systemic symptoms than in children who were pauciarticular. In systemic JIA, positive correlation was found between sICAM-1 as well as sE-selectin levels and ESR and WBC. Levels of sICAM-1 and sE-selectin were significantly higher in children with abnormal values of ESR versus patients with normal values (p &lt; 0.05 and p &lt; 0.05, respectively). Similarly, significantly higher levels of sICAM-1, sE-selectin and sP-selectin were recorded in cases with higher number of WBC in comparison with others (p &lt; 0.05, p &lt; 0.025, p &lt; 0.02, respectively). In patients with scleroderma sE-selectin level was lower than in polyarticular form (p &lt; 0.05) and the concentration of both sICAM-1 and sE-selectin were significantly lower than in systemic JIA (p &lt; 0.05 and p &lt; 0.05, respectively). In contrast, sVCAM-1 levels were significantly higher only in scleroderma children in comparison with pauciarticular (p &lt; 0.02) and higer than in polyarticular and equal to the systemic group. <h3>Conclusion</h3> The preliminary results indicate the role of sVCAM-1 in the pathogenesis of childhood-onset scleroderma and confirm the differences between subtypes of JIA and suggest that sICAM-1 and sE-selectin may be another useful tool of monitoring the activity of systemic JIA.
Abstract 2087: Angiotensin II Receptor Blocker Regresses Left Ventricular Hypertrophy and Increases Myocardial Blood Volume in Hypertensive Patients
Authors: Satoshi Yamada, Hiroshi Komatsu, Masako Okada, Hisao Onozuka, Taisei Mikami, Hiroyuki Tsutsui
Journal: Circulation (2007)

Introduction: Left ventricular hypertrophy (LVH), the most common cardiac consequence of hypertension, is an independent strong risk factor for cardiovascular mortality and morbidity. LVH is associ...
The Multi-Ethnic Study of Atherosclerosis (MESA) and Myocardial Function: Where Is the Boundary Between Risk Factor and Disease?⁎⁎Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology
Authors: Nathaniel Reichek
Journal: Journal of the American College of Cardiology (2006)
Opportunity costs of undergoing surgical resection and perioperative chemotherapy for pancreatic adenocarcinoma.
Authors: Szu-Aun Lim, Scarlett Hao, Breana Boyd, Anastasios Mitsakos, William Irish, Alexander A. Parikh, Rebecca A Snyder
Journal: Journal of Clinical Oncology (2021)

398 Background: Treatment of early stage pancreatic ductal adenocarcinoma (PDAC) includes surgical resection and either neoadjuvant or adjuvant chemotherapy. Due to the intensity of treatment and perioperative morbidity rates of pancreatic resection, patients may spend a significant portion of their survival time in receipt of clinical care. However, time spent in receipt of care has not been previously described in patients with early stage PDAC. The primary aim of this study was to determine the total time spent in receipt of surgical and perioperative chemotherapy in patients with resectable PDAC. Methods: A retrospective cohort study was performed of patients diagnosed with PDAC who underwent curative-intent resection at a single institution tertiary care center between January 2015 and October 2019. Patients who died within 30 days of surgery were excluded. Total care time, including all relevant clinician visits, laboratory, radiologic and procedural studies, and treatment visits, was abstracted from the primary medical record. Care time included estimated travel time based on patient address. Care time was divided into preoperative, surgical, and systemic therapy phases of care. Time spent in surgical care included the hospital length of stay, postoperative follow-up visits, and admissions for postoperative complications. Results: A total of 86 patients were identified. Median total preoperative care time was 29 hours (IQR 11-135; 0.4% of survival time, range 0% - 72.7%). Median total time spent in surgical care was 216 hours (IQR 164-371; 2% of survival time, range 0.3% - 68.4%). Among the patients who received systemic chemotherapy care within the same institutional health system (N = 41), median total time spent in receipt of systemic therapy was 447 hours (IQR 194-647; 3% of survival time, range 0.1% - 55.4%). 10.5% of patients (N = 9) spent more than 10% of total survival time in surgical care and 5.8% (N = 5) patients spent more than 10% of survival time in receipt of systemic care. Median cumulative travel time for patients was 19 hours (IQR 10.2-37.6). Conclusions: For the majority of patients undergoing resection for PDAC, time spent in receipt of surgical care does not appear to represent a substantial time burden relative to survival time. However, for a subset of patients, the time burden is considerable. Further research to determine predictors of increased time spent in receipt of multimodality cancer care is warranted to better inform patient and surgeon communication and decision-making.
The Noninvasive Ventilation Outcomes (NIVO) score: prediction of in-hospital mortality in exacerbations of COPD requiring assisted ventilation
Authors: Tom Hartley, Nicholas D. Lane, John Steer, Mark W. Elliott, Milind P. Sovani, Helen Jane Curtis, Elizabeth R. Fuller, Patrick B. Murphy, Dinesh Shrikrishna, Keir E. Lewis, Neil R. Ward, Chris D. Turnbull, Nicholas Hart, Stephen C. Bourke
Journal: European Respiratory Journal (2021)

Acute exacerbations of COPD (AECOPD) complicated by acute (acidaemic) hypercapnic respiratory failure (AHRF) requiring ventilation are common. When applied appropriately, ventilation substantially reduces mortality. Despite this, there is evidence of poor practice and prognostic pessimism. A clinical prediction tool could improve decision making regarding ventilation, but none is routinely used.
Child Sexual Abuse as a Unique Risk Factor for the Development of Psychopathology: The Compounded Convergence of Mechanisms
Authors: Jennie G. Noll
Journal: Annual Review of Clinical Psychology (2021)

Meta-analytic, population cohort, prospective, and clinical studies provide systematic evidence that child sexual abuse accounts for unique variation in several deleterious outcomes. There is strong evidence for psychiatric disorders, including posttraumatic stress disorder and mood, anxiety, and substance use disorders, and mixed evidence for personality disorders. Evaluation of sex-specific outcomes shows strong evidence for teenage childbearing, sexual revictimization, and sexual dysfunction and mixed evidence for heightened sexual behaviors and sexual offending. This review further demonstrates not only that survivors suffer the noxious impact of traumatic sexualization but that additional transdiagnostic mechanisms, including the biological embedding of stress, emotion dysregulation, avoidance, and insecure attachment, converge to compound risk for deleterious outcomes. A road map to enhance the rigor of future research is outlined, and specific recommendations for evidence-based policy making to boost prevention efforts and increase access to treatment are discussed.
Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response
Authors: Laura Poillet-Perez, Daniel W. Sharp, Yang Yang, Saurabh V. Laddha, Maria Ibrahim, Praveen K. Bommareddy, Zhixian Sherrie Hu, Joshua Vieth, Michael Haas, Marcus W. Bosenberg, Joshua D. Rabinowitz, Jian Cao, Jun-Lin Guan, Shridar Ganesan, Chang S. Chan, Janice M. Mehnert, Edmund C. Lattime, Eileen White
Journal: Nature Cancer (2020)
Endothelial cells in the pathogenesis of pulmonary arterial hypertension
Authors: Colin E. Evans, Nicholas D. Cober, Zhiyu Dai, Duncan J. Stewart, You-Yang Zhao
Journal: European Respiratory Journal (2021)

Pulmonary arterial hypertension (PAH) is a devastating disease that involves pulmonary vasoconstriction, small vessel obliteration, large vessel thickening and obstruction, and development of plexiform lesions. PAH vasculopathy leads to progressive increases in pulmonary vascular resistance, right heart failure and, ultimately, premature death. Besides other cell types that are known to be involved in PAH pathogenesis ( e.g. smooth muscle cells, fibroblasts and leukocytes), recent studies have demonstrated that endothelial cells (ECs) have a crucial role in the initiation and progression of PAH. The EC-specific role in PAH is multi-faceted and affects numerous pathophysiological processes, including vasoconstriction, inflammation, coagulation, metabolism and oxidative/nitrative stress, as well as cell viability, growth and differentiation. In this review, we describe how EC dysfunction and cell signalling regulate the pathogenesis of PAH. We also highlight areas of research that warrant attention in future studies, and discuss potential molecular signalling pathways in ECs that could be targeted therapeutically in the prevention and treatment of PAH.
Autoantibodies targeting telomere-associated proteins in systemic sclerosis
Authors: Brittany L Adler, Francesco Boin, Paul J Wolters, Clifton O Bingham, Ami A Shah, Carol Greider, Livia Casciola-Rosen, Antony Rosen
Journal: Annals of the Rheumatic Diseases (2021)

Systemic sclerosis (SSc) is an autoimmune fibrotic disease affecting multiple tissues including the lung. A subset of patients with SSc with lung disease exhibit short telomeres in circulating lymphocytes, but the mechanisms underlying this observation are unclear.