tbuckley/cabot-search huggingface dataset:
MEDICAL NEWS
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Journal of Nutrition, Philadelphia
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Creatine kinase-MB elevation after percutaneous coronary intervention is a predictor of long-term mortality in patients with renal dysfunction Allen Jeremias, Abdulhay Albirini, Khaled M. Ziada, Derek P. Chew, Marco Roffi, Paul Schoenhagen, Sorin J. Brener, Stephen G. Ellis, Eric J. Topol. Cleveland Clinic Foundation, Cleveland, OH
Journal: Journal of the American College of Cardiology (2001)
Effect of <i>Lactobacillus rhamnosus</i> GG on Incident Pneumonia in Critically Ill Patients
Authors: Cheng-Yi Wang, Chao-Hsien Chen, Chih-Cheng Lai
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Structure is Worth a Thousand Words: New Insights for RAS and RAF Regulation
Authors: Dhirendra K. Simanshu, Deborah K. Morrison
Journal: Cancer Discovery (2022)

Abstract The RAS GTPases are frequently mutated in human cancer, with KRAS being the predominant tumor driver. For many years, it has been known that the structure and function of RAS are integrally linked, as structural changes induced by GTP binding or mutational events determine the ability of RAS to interact with regulators and effectors. Recently, a wealth of information has emerged from structures of specific KRAS mutants and from structures of multiprotein complexes containing RAS and/or RAF, an essential effector of RAS. These structures provide key insights regarding RAS and RAF regulation as well as promising new strategies for therapeutic intervention. Significance: The RAS GTPases are major drivers of tumorigenesis, and for RAS proteins to exert their full oncogenic potential, they must interact with the RAF kinases to initiate ERK cascade signaling. Although binding to RAS is typically a prerequisite for RAF to become an activated kinase, determining the molecular mechanisms by which this interaction results in RAF activation has been a challenging task. A major advance in understanding this process and RAF regulation has come from recent structural studies of various RAS and RAF multiprotein signaling complexes, revealing new avenues for drug discovery.
Hantavirus Pulmonary Syndrome—Virginia, 1993
Journal: JAMA (1994)

Hantavirus pulmonary syndrome (HPS) was first recognized in June 1993 as a result of the investigation of a cluster of fatal cases of adult respiratory distress syndrome (ARDS) in the southwestern United States (1). During that month, a 61-year-old man was admitted to a hospital in southern Pennsylvania with ARDS; recent testing of all available specimens from this patient has confirmed the diagnosis of HPS. This report summarizes the case investigation.
Glycoprotein Ia C807T polymorphism and risk of restenosis following coronary artery stenting Nicolas von Beckerath, Werner Koch, Julinda Mehilli, Corinna B�ttiger, Siegmund Braun, Albert Sch�mig, Adnan Kastrati. Deutsches Herzzentrum, Munich, Germany
Journal: Journal of the American College of Cardiology (2001)
SOCIETY PROCEEDINGS.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Association between household air pollution and nasopharyngeal pneumococcal carriage in Malawian infants (MSCAPE): a nested, prospective, observational study
Authors: Mukesh K Dherani, Daniel Pope, Terence Tafatatha, Ellen Heinsbroek, Ryan Chartier, Thandie Mwalukomo, Amelia Crampin, Elena Mitsi, Esther L German, Elissavet Nikolaou, Carla Solórzano, Daniela M Ferreira, Todd D Swarthout, Jason Hinds, Kevin Mortimer, Stephen B Gordon, Neil French, Nigel G Bruce
Journal: The Lancet Global Health (2022)
Access to COVID-19 vaccines: looking beyond COVAX
Authors: None The Lancet
Journal: The Lancet (2021)

Global health leaders have been in a congratulatory mood. On March 1, they celebrated the first vaccinations against COVID-19 in Africa delivered through COVAX—the scheme led by GAVI, CEPI, and WHO to support research and development, raise funding, and negotiate the bulk purchase and equitable global distribution of vaccines for COVID-19. As of March 9, 12 million doses have been shipped to 29 countries, marking the beginning of the largest vaccine roll-out in history. This is an unprecedented achievement.
American Heart Journal, St. Louis
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
T wave alternans is prevalent and correlates with NYHA functional class, LV function, and size in patients with idiopathic dilated cardiomyopathy Yee Guan Yap, Kudret Aytemir, Niall Mohan, Mark Gallagher, William McKenna, A. John Camm. St. George's Hospital Medical School, London, United Kingdom
Journal: Journal of the American College of Cardiology (2001)
THE CHIROPRACTIC THEORY OF PATRIOTISM
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reference Committees of the House of Delegates
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparison of Sequential Vs Alternating Administration of Bortezomib, Melphalan, Prednisone (VMP) and Lenalidomide Plus Dexamethasone (Rd) in Elderly Pts with Newly Diagnosed Multiple Myeloma (MM) Patients: GEM2010MAS65 Trial
Authors: Maria-Victoria Mateos, Joaquin Martinez-Lopez, Miguel-T Hernandez, Rafael Martinez, Laura Rosiñol, Enrique M. Ocio, Maria Asuncion Echeveste, Jaime Pérez de Oteyza, Albert Oriol, Joan Bargay, Mercedes Gironella, Jesús Martín, Carmen Cabrera, Javier De La Rubia, Norma C Gutiérrez, Maria-Luisa Martin, Bruno Paiva, Maria Angeles Montalbán, Joan Bladé, Juan José Lahuerta, Jesus F. San Miguel
Journal: Blood (2014)
Phase I/II trial of encorafenib, cetuximab, and nivolumab in patients with microsatellite stable, <i>BRAF</i><sup>V600E</sup> metastatic colorectal cancer.
Authors: Van K. Morris, Christine Megerdichian Parseghian, Michelle Escano, Benny Johnson, Kanwal Pratap Singh Raghav, Arvind Dasari, Ryan Huey, Michael J. Overman, Jason Willis, Michael Sangmin Lee, Robert A. Wolff, Bryan K. Kee, John Paul Y.C. Shen, Maria Pia Morelli, Alda Tam, Wai Chin Foo, Lianchun Xiao, Scott Kopetz
Journal: Journal of Clinical Oncology (2022)

12 Background: Encorafenib (E) and cetuximab (C) offers short-lived response and survival benefit for patients (pts) with MSS, BRAF V600E metastatic colorectal cancer (CRC). BRAF + EGFR inhibition induced a transient MSI-H phenotype in preclinical models of MSS, BRAF V600E CRC and may prime these tumors for response to immunotherapy with anti-PD-1 antibodies like nivolumab (N). Methods: In this single-arm, single-institution, phase I/II clinical trial, pts with treatment-refractory MSS, BRAF V600E metastatic CRC were eligible. No prior BRAF inhibitors, anti-EGFR antibody, or immunotherapy was permitted. Pts received E (300 mg PO daily), C (500 mg/m 2 IV q14 days), and N (480 mg IV q28 days). The primary endpoints were best overall response (RECIST 1.1) and safety/tolerability (CTCAE v5). A Simon two-stage design (H 0 : p≤.22; H a : p≥.45, where p= percentage of pts with radiographic response) was employed using a one-sided α=.05 and β=.20. In the first stage, ≥ 4/15 responses were needed in order for the trial to enroll 11 additional pts. Median progression-free survival (PFS) and overall survival (OS) were estimated via Kaplan-Meier. Results: All 26 pts have been enrolled - 23 patients treated, and 21 evaluable for response so far. Median age is 59 years (range, 32-85), and 14 (54%) are female. No dose-limiting toxicities occurred. Grade 3-4 treatment-related adverse events (AE) occurred in 4/22 (18%) patients. Grade 3 AEs included colitis, maculopapular rash, leukocytosis, and elevated amylase/lipase (all N=1). Grade 4 AEs in a single patient were myositis/myocarditis. Overall response rate is 45% (95% CI, 23-68), and disease control rate is 95% (95% CI, 75-100). Median PFS is 7.3 months (95% CI, 5.5-NA). Median OS is 11.4 months (95% CI, 7.6-NA). For the 9 pts thus far with responses, median duration of response is 8.1 months (95% CI, 7.3-NA). Updated results will be presented. Conclusions: E + C + N is effective and well-tolerated for pts with MSS, BRAF V600E metastatic CRC. The E+C+N regimen met its predefined efficacy endpoint and suggests a role for immunotherapy as a novel combination approach for this specific subpopulation of MSS metastatic CRC. A follow-up randomized phase II trial (SWOG 2107) to evaluate encorafenib/cetuximab with or without nivolumab in pts with MSS, BRAF V600E metastatic CRC will activate in early 2022. Clinical trial information: NCT04017650.
Effects of long-term selective ETA receptor blockade on neurohumoral activation in congestive heart failure Frank Ruschitzka, Frank Enseleit, David Hurlimann, Richard Pacher, Veselin Mitrovic, Matthias R. Schulze, Wolfgang Kiowski, Georg Noll, Thomas F. Luscher. University Hospital, Zurich, Switzerland
Journal: Journal of the American College of Cardiology (2001)
Recent research in infectious disease
Authors: Douglas Walsh
Journal: Journal of Infection (2005)

Recent research in infectious disease *Tafenoquine is more effective than primaquine for preventing malaria relapse ST.LOUIS (MD Consult)-In some areas of Thailand in which Plasmodium vivax is endemic, reports of primaquine failure are increasing.Tafenoquine (WR238605), a synthetic primaquine analog, is an effective and safe alternative to primaquine for preventing relapse after chloroquine therapy, according to the October 15 Clinical Infectious Diseases.
The question mark of uncertainty
Authors: S. Vaisrub
Journal: JAMA (1977)

Readers of medical journals can hardly fail to note the increasing number of editorials bearing titles that end with a question mark. This trend is a departure from tradition. An editorial is expected to express an opinion, to make an authoritative statement, to provide an answer rather than to pose a question. Questions are not always inseparably wedded to answers. The rhetorical question, for instance, requires no answer because the latter is obvious (Isn't good health desirable?). The answer, on the other hand, is far from obvious—in fact, it is usually impossible—to a metaphysical question (When did time begin? What is life?). Between these two extremes are more or less answerable questions that differ from one another by their intent. This may be a demand for information, a request for help, a test of knowledge, a researcher's probe, an inquisitor's trip-up, a debater's spar, or an opponent's heckle. The question
Correlation of surgical volume and outcomes with gastrectomy.
Authors: Cassandra Schuster, Jamie Glasser, Jamie Huston, Ravi Shridhar, Kenneth Lee Meredith
Journal: Journal of Clinical Oncology (2022)

272 Background: Gastric cancer(GC) is associated with significant mortality worldwide. Radical gastrectomy with lymphadenectomy is considered the only curative option for GC. Traditionally, these operations are associated with significant morbidity. However, a significant proportion of gastric resections are performed at low volume centers. We sought to compare oncologic outcomes of gastrectomy by surgical volume. Methods: Utilizing the National Cancer Database we identified patients with gastric cancer who underwent gastrectomy. We then stratified based upon volume of institution. Low volume(LV) &lt; 10 gastric resections per year, and high volume(HV) &gt; 10 gastric resections per year. Mann-Whitney U and Kruskal were used to compare continuous variables and Pearson’s Chi-square test was used to compare categorical variables. Unadjusted survival analyses were performed using the Kaplan-Meier method. Multivariate analysis (MVA) was performed to identify predictors of survival. All statistical tests were two-sided and p &lt; 0.05 was considered significant. Results: We identified 29,216 patients who underwent gastrectomy with a median age of 66.5 (18-90) years. There were 21,166 (72%) gastric resections performed at LV centers and 8,050 at HV centers, p &lt; 0.001. Neoadjuvant therapy was most often utilized in the HV centers at 41.7% vs 24.1% in the LV centers, p &lt; 0.001. The median number of lymph nodes removed were 19 (13-28) in the HV and 14 (8-21) in the LV groups respectively, p &lt; 0.001. The R0 resection rates were 91.1% in high volume centers and 84.6% in the low volume centers p &lt; 0.001. The length of hospitalization did not differ between groups (median 8 (6-12) days), p = 0.33. The 30-day readmission rates however, were higher in the low volume centers at 6.5% compared to 5.8% in the high volume centers. The 30 and 90-day mortality was 1.7% and 4.1% in the HV and 4.9% and 9.2% in the LV groups, p &lt; 0.001 and p &lt; 0.001 respectively. The median and overall 5-year survival was 83.8mo and 56% in the HV and 49.4mo and 46% in the LV cohorts, p = 0.001. Multivariate analysis revealed that age, sex, Charlson/Deyo score, tumor location, histology, grade, stage, facility volume, and neoadjuvant therapy were all predictors of survival. Conclusions: While the majority of gastric resections are performed at LV centers, oncologic outcomes, survival and mortality rates are worse compared to patients who undergo gastric resection at high volume centers. Gastric resections should be regionalized to high volume centers to ensure the best surgical and oncologic outcomes.
Re: Jan-Niclas Mumm, Andreas Osterman, Michael Ruzicka, et al. Urinary Frequency as a Possible Overlooked Symptom in COVID-19 Patients: Does SARS-CoV-2 Cause Viral Cystitis? Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.05.013
Authors: Lorenzo G. Luciani, Fabrizio Gallo, Gianni Malossini
Journal: European Urology (2020)
Correction: Impact of PD-1 Blockade on Severity of COVID-19 in Patients with Lung Cancers
Journal: Cancer Discovery (2021)

In the original version of this article (1), the prevalence rates of COVID-19 in patients with COPD baseline were incorrectly stated in both the "No prior PD-1 blockade (n = 28)" and "Prior PD-1 blockade (n = 41)" columns in Table 2.We have corrected these errors by replacing "9%" with "11%" in the column titled "No prior PD-1 blockade (n = 28)" and "36%" with "22%" in the column titled "Prior PD-1 blockade (n = 41)" in latest online HTML and PDF versions of the article.The authors regret the error.