tbuckley/cabot-search huggingface dataset:
Accelerated "atherosclerosis". A morphologic study of 97 saphenous vein coronary artery bypass grafts.
Authors: B HBulkley, G MHutchins
Journal: Circulation (1977)

Intimal thickening of uncertain cause has been noted in saphenous vein bypass grafts. To study the development of these changes, 97 vein grafts in 55 autopsied patients were examined by angiography and histology. Significant alterations in the grafts were confined to the intima and included thin layers of circumferential thrombus, concentric fibrous plaque and occlusive thrombus with organization. Circumferential nonocclusive intimal thrombus was present in 36 (73%) postoperative patent grafts. Concentric fibrous plaque, found in all twelve patent late grafts, showed changes characteristic of atheromata, including smooth muscle and foam cells. Intimal fibroelastosis was absent in the grafts, indicating that concentric plaque is not a simple response to increased pressure, or an arterialization of the vein. The findings suggest that early appearing concentric intimal thrombus is converted into fibrous plaque, and that this early thrombus is a factor in the development of acclereated atherosclerosis in ...
RNA-sequencing data-driven dissection of human plasma cell differentiation reveals new potential transcription regulators
Authors: Alboukadel Kassambara, Laurie Herviou, Sara Ovejero, Michel Jourdan, Coraline Thibaut, Veronika Vikova, Philippe Pasero, Olivier Elemento, Jérôme Moreaux
Journal: Leukemia (2021)

Abstract Plasma cells (PCs) play an important role in the adaptive immune system through a continuous production of antibodies. We have demonstrated that PC differentiation can be modeled in vitro using complex multistep culture systems reproducing sequential differentiation process occurring in vivo. Here we present a comprehensive, temporal program of gene expression data encompassing human PC differentiation (PCD) using RNA sequencing (RNA-seq). Our results reveal 6374 differentially expressed genes classified into four temporal gene expression patterns. A stringent pathway enrichment analysis of these gene clusters highlights known pathways but also pathways largely unknown in PCD, including the heme biosynthesis and the glutathione conjugation pathways. Additionally, our analysis revealed numerous novel transcriptional networks with significant stage-specific overexpression and potential importance in PCD, including BATF2, BHLHA15/MIST1, EZH2, WHSC1/MMSET, and BLM. We have experimentally validated a potent role for BLM in regulating cell survival and proliferation during human PCD. Taken together, this RNA-seq analysis of PCD temporal stages helped identify coexpressed gene modules with associated up/downregulated transcription regulator genes that could represent major regulatory nodes for human PC maturation. These data constitute a unique resource of human PCD gene expression programs in support of future studies for understanding the underlying mechanisms that control PCD.
Routine primary repair vs two-stage repair of tetralogy of Fallot.
Authors: J WKirklin, E HBlackstone, A DPacifico, R NBrown, L MBargeron
Journal: Circulation (1979)

Fifteen of 194 patients (7.7%) with tetralogy of Fallot operated upon since January 1, 1972 under a protocol of routine primary repair despite young age died in-hospital. Most deaths were from low cardiac output. Young age and smallness of size increased the risk of operation. No deaths occurred among patients older than 4 years. High hematocrit was also a risk factor. Transannular patching has an independent effect in increasing risk. The post-repair ratio of peak pressure in the right ventricle to that in the left did not exert an independent effect. To project current risks of a two-stage approach, we determined that five of 158 patients (3.2%) died in-hospital after secondary intracardiac repair after a previous Blalock-Taussig or Waterston anastomosis between 1967--1978. Using these data and those we have published on the risk of shunting, we project that except in very small babies, the risks of hospital death of a two-stage approach are not less than those of primary repair done without a transannu...
Electrophysiological effects of hypertonic sucrose solutions on canine cardiac Purkinje fibers.
Authors: J CBailey
Journal: Circulation Research (1981)

Microelectrode techniques were used to study the electrophysiological effects of hypertonic solutions on canine cardiac Purkinje fibers. Tyrode's solution was rendered hyperosmotic by the addition of sucrose to produce 320, 350, 400, and 500 mOsm solutions. Hyperosmotic solutions produced sucrose concentration-dependent hyperpolarization, increased the current required to effect all-or-none depolarization, slowed transmission, and prolonged action potential duration. The action potential prolongation was reversed or prevented by lidocaine (10-5 M). Treatment of potassium-depolarized Purkinje fibers with hypertonic solutions produced hyperpolarization, increased Vmax phase 0, decreased the current required to evoke all-or-none depolarization, increased action potential duration, and increased transmission speed. The potent electrophysiological actions of hypertonic sucrose solutions probably derive from their osmotic effects rather than from selective actions at specific membrane sites or hormone receptors.
Mechanisms by which epinephrine augments cerebral and myocardial perfusion during cardiopulmonary resuscitation in dogs.
Authors: J RMichael, A DGuerci, R CKoehler, A YShi, JTsitlik, NChandra, ENiedermeyer, M CRogers, R JTraystman, M LWeisfeldt
Journal: Circulation (1984)

The goals of this study were to quantify the effects of epinephrine on myocardial and cerebral blood flow during conventional cardiopulmonary resuscitation (CPR) and CPR with simultaneous chest compression-ventilation and to test the hypothesis that epinephrine would improve myocardial and cerebral blood flow by preventing collapse of intrathoracic arteries and by vasoconstricting other vascular beds, thereby increasing perfusion pressures. Cerebral and myocardial blood flow were measured by the radiolabeled microsphere technique, which we have previously validated during CPR. We studied the effect of epinephrine on established arterial collapse during CPR with simultaneous chest compression-ventilation with the abdomen bound or unbound. Epinephrine reversed arterial collapse, thereby eliminating the systolic gradient between aortic and carotid pressures and increasing cerebral perfusion pressure and cerebral blood flow while decreasing blood flow to other cephalic tissues. Epinephrine produced higher cer...
BRD4 Proteolysis Targeting Chimera (PROTAC) ARV-825 Targets Both NOTCH1-MYC Regulatory Circuit and Leukemia-Microenvironment in T-ALL
Authors: Sujan Piya, Hong Mu, Seemana Bhattacharya, Teresa McQueen, Richard E Davis, Vivian Ruvolo, Natalia Baran, Yimin Qian, Kanak Raina, Craig M Crews, M. James You, Patrick Zweider McKay, Marina Konopleva, Hagop M. Kantarjian, Michael Andreeff, Gautam Borthakur
Journal: Blood (2017)
Ads from the Partnership for a Drug-Free America
Authors: P. DuBay
Journal: JAMA (1992)

Drug-Free America To the Editor.\p=m-\Here are some facts concerning the Partnership for a Drug\x=req- Free America (PDFA) advertisement that appeared in an issue of JAMA.1 Addressing the psychiatric profession, the advertisement stated, The side effects of self-medication with marijuana may themselves be a major component of a patient's psychiatric profile. No other substances already proven to be
Cardiac noradrenergic nerve terminal abnormalities in dogs with experimental congestive heart failure.
Authors: YHimura, S YFelten, MKashiki, T JLewandowski, J MDelehanty, C SLiang
Journal: Circulation (1993)

BACKGROUNDWe have shown previously that norepinephrine (NE) uptake activity is reduced in the failing right ventricle of animals with right heart failure (RHF) produced by tricuspid avulsion and progressive pulmonary constriction. However, it is unknown whether this defect in neuronal NE uptake is related to reduction of noradrenergic nerve terminals or whether these changes also occur in animals with left heart failure (LHF). It is also unknown whether increased NE release in heart failure contributes to the noradrenergic nerve abnormalities.METHODS AND RESULTSWe measured myocardial NE content. NE uptake function, and noradrenergic nerve profiles in dogs with either RHF or LHF induced by rapid ventricular pacing. NE uptake activity was measured using [3H]NE, and noradrenergic nerve profiles were visualized by glyoxylic acid (SPG)-induced histofluorescence and tyrosine hydroxylase immunocytochemical staining. To study the effects of excess NE, we exposed normal dogs to 8 weeks of chronic NE infusion using...
Selective antagonism of hormone-induced vasoconstriction by synthetic atrial natriuretic factor in the rat microcirculation.
Authors: K GProctor, S LBealer
Journal: Circulation Research (1987)

Synthetic atrial natriuretic factor (ANF) was either added to suffusate solutions (30 nM) or infused into the jugular vein (0.1 nanomol/min/100 g) of anesthetized rats. Steady-state blood flow was calculated from arteriolar diameter and red blood cell velocity measurements using video microscopy in the intestinal or skeletal muscle microcirculation. Arterioles demonstrated spontaneous vasomotor tone by dilating to topical adenosine, but topical or intravenous ANF did not cause vasodilation. Either angiotensin, norepinephrine, or vasopressin was added to the suffusates in the presence or absence of a cyclooxygenase inhibitor (30 microM, meclofenamate or indomethacin) because each agonist is known to stimulate vasoactive prostanoid synthesis. In the intestine, angiotensin (500 nM) caused 40 +/- 2% blood flow decreases during intravenous saline but only 23 +/- 6% during intravenous ANF. Angiotensin (162 nM) and a cyclooxygenase inhibitor caused 19 +/- 4% blood flow decreases but only 8 +/- 5% decreases with ...
Abstract 13288: Epoxigenated Omega-3 Fatty Acid Metabolites Produced by Mast Cells Attenuate Pulmonary Vascular Remodeling
Authors: Hidenori Moriyama, Jin Endo, Masaharu Kataoka, Motoaki Sano, Keiichi Fukuda
Journal: Circulation (2019)

Introduction: Omega-3 fatty acid and its metabolites are well-known as lipid molecules having various cardioprotective roles, however little is known about their impacts for pulmonary hypertension ...
Ceruletide for retained biliary stones.
Authors: S J Walker, C R Mackie, R M Mendelson, A Arnold, M R Colmer
Journal: BMJ (1986)

A skull fracture is associated with an intracranial mass lesion in three quarters of patients.3Absence of a fracture does not exclude serious head injury: 35% of patients in coma and 200/% of those dying after head injury do not have a skull fracture.3Computed tomography is mandatory for head injured patients in coma (Glasgow coma scale 8), and measurement of intracranial pressure may be useful.Half of head injured patients admitted in coma have a raised intracranial pressure, and intracranial pressure is raised in 30%/o of cases without haematoma.4Raised intracranial pressure is also a feature of severe near drowning, reflecting the primary hypoxic insult.When the intracranial pressure is greater than 20 mm Hg after near drowning outcome is poor (death in 70%/o of patients, a vegetative state in 30%). 5 In our patient attributing the neurological signs to severe head injury led to unnecessary monitoring of intracranial pressure and might have led inexperienced staff to diagnose post-traumatic brain stem failure and withdraw supportive treatment.When examining unconscious patients the core temperature should be measured and clinical signs interpreted accordingly.
Risk of Colorectal Cancer After Detection of Low-Risk or High-Risk Adenomas, Compared with no Adenoma, at Screening Colonoscopy: a Systematic Review and Meta-Analysis
Authors: G Antonelli, A Duvvuri, V Thoguluva Chandrasekar, M Spadaccini, A Repici, C Hassan, P Sharma
Journal: Endoscopy (2021)

Aims The risk of metachronous colorectal cancer (CRC) among patients with no adenomas, low-risk adenomas (LRAs), or high-risk adenomas (HRAs), detected at index screening colonoscopy, is unclear. We performed a systematic review and meta-analysis to compare incidence rates of metachronous CRC and CRC-related mortality after a baseline colonoscopy for each group.
Effects of bigeminies and paired-pulse stimulation on oxygen consumption in dog left ventricle.
Authors: TNozawa, YYasumura, SFutaki, NTanaka, HSuga
Journal: Circulation Research (1990)

In 10 excised, cross-circulated, isovolumically beating dog left ventricles, we examined the effects of bigeminy, including paired-pulse stimulation, on cardiac oxygen consumption (VO2) and evaluated whether the VO2 versus pressure-volume area (PVA) relation obtained from regularly beating hearts in our previous studies could account for the changes in VO2 during bigeminies with various coupling intervals. The extrasystolic interval (ESI) was decreased in four steps from 300 msec (regular rhythm) to paired-pulse stimulation (less than or equal to 210 msec). The sum of ESI and the postextrasystolic interval was always held constant (600 msec); therefore, the number of excitations was 200/min at any ESI. Both VO2 and PVA were measured in four runs: a small volume run at a ventricular volume of 13 ml, a large volume of 12 ml, a calcium run in which contractility was enhanced by CaCl2 at a small volume of 12 ml, and a verapamil run in which contractility was depressed by verapamil at a large volume of 20 ml. ...
Cardioversion and "false positive" technetium-99m stannous pyrophosphate myocardial scintigrams.
Authors: B RPugh, L MBuja, R WParkey, L RPoliner, E MStokely, F JBonte, J TWillerson
Journal: Circulation (1976)

The present studies performed in experimental animals demonstrate that electrical direct current cardioversion can produce skeletal muscle damage and increased technetium-99m stannous pyrophosphate (99mTc-PYP) uptake; in experimental animals the electrically damaged skeletal muscle shows necrosis with extensive calcium deposition. In addition, the frequent administration of high energy cardioversion produces myocardial necrosis with calcium deposition, increased 99mTc-PYP myocardial uptake and a positive 99mTc-PYP myocardial scintigram. The data indicate that, if diagnostic 99mTc-PYP myocardial scintigraphy is contemplated after cardioversion, paddle placement should be slightly removed from the anteroposterior projection of the heart on the external chest wall to avoid possible subsequent confusion between increased myocardial and skeletal muscle uptake of 99mTc-PYP. If multiple high energy cardioversion episodes are necessary, myocardial necrosis resulting from electrical injury may occur and be responi...
Five-year follow-up of maximal treadmill stress test in asymptomatic men and women.
Authors: W HAllen, W SAronow, PGoodman, PStinson
Journal: Circulation (1980)

A five-year follow-up of 888 asymptomatic men and women without known coronary heart disease (CHD) who had a maximal treadmill stress test (MTST) revealed a CHD incidence of 1.1% per year. In women, exercise duration of 3 minutes or less by the Ellestad protocol correlated with subsequent development of CHD (p less than 0.001), although abnormal ST-segment and R-wave responses did not. In men 40 years of age or younger, the MTST did not correlate with subsequent CHD. In men older than 40 years, ischemic ST response (p less than 0.01), an increase or no change in R wave (p less than 0.01), and an exercise duration of 5 minutes of less (p less than 0.001) all correlated with subsequent development of CHD. Five of five men (100%) who had all three criteria developed CHD within 5 years. When men older than 40 years who had all three criteria either present or absent were considered, specificity was 100%. The sensitivity, specificity, predictive value of an abnormal test, and risk ratio for developing CHD with...
Myocardial function of the interventricular septum. Effects of right and left ventricular pressure loading before and after pericardiotomy in dogs.
Authors: MMolaug, OStokland, AIlebekk, JLekven, FKiil
Journal: Circulation Research (1981)

We examined the function of the interventricular septum in six open-chest dogs by inserting piezoelectric crystals into the interventricular septum. Continuous ultrasonic recordings showed that the changes in myocardial chord length (MCL) in the septum and free walls of the right and left ventricle were similar during saline infusion and during pericardiotomy. End-diastolic MCL and myocardial shortening during ejection (MS) rose in the septum and free walls of both ventricles during saline infusion as end-diastolic MCL and MS in the septum and free walls of the ventricles, and reduced end-diastolic pressures by 1-2 mm Hg. The responses to aortic and pulmonary artery constrictions were similar before and after pericardiotomy. When aortic constriction had raised free left ventricular systolic pressure by about 60 mm Hg, end-diastolic MCL increased in the septum and free left ventricular wall, whereas end-diastolic MCL and MS of the free right ventricular wall fell. Pulmonary artery constriction increased en...
Cardiac specific creatine phosphokinase isoenzyme in the diagnosis of acute myocardial infarction.
Authors: M AVarat, D WMercer
Journal: Circulation (1975)

The specific and sensitivity of serum creatine phosphokinase cardiac specific isoenzyme (MB) in the diagnosis of acute myocardial infarction (AMI) was evaluated. An ion-exchange chromatographic technique was used to isolate MB. Sera layered on mini-columns of DEAE-Sephadex were eluted with Tris-buffered sodium chloride. Quantification of isolated MB was performed by creatine phosphokinase (CPK) assay (Rosalki method) of column effluents. MB was expressed as a percentage of the simultaneously determined total serum CPK; MB was determined in 100 consecutive admissions to the Coronary Care Unit. Acute myocardial infarction was diagnosed by accepted criteria. In 47 patients with proven AMI, including three with normal total CPK, peak MB was greater than 4% of total CPK. In 49 patients without AMI, including 15 with elevated total CPK (due to trauma, injections, cardioversion), peak MB was less than 2% of total CPK. MB was elevated, but did not peak in four patients without AMI but with chronic atrial fibrilla...
Soft, skin-interfaced sweat stickers for cystic fibrosis diagnosis and management
Authors: Tyler R. Ray, Maja Ivanovic, Paul M. Curtis, Daniel Franklin, Kerem Guventurk, William J. Jeang, Joseph Chafetz, Hannah Gaertner, Grace Young, Steve Rebollo, Jeffrey B. Model, Stephen P. Lee, John Ciraldo, Jonathan T. Reeder, Aurélie Hourlier-Fargette, Amay J. Bandodkar, Jungil Choi, Alexander J. Aranyosi, Roozbeh Ghaffari, Susanna A. McColley, Shannon Haymond, John A. Rogers
Journal: Science Translational Medicine (2021)

The concentration of chloride in sweat remains the most robust biomarker for confirmatory diagnosis of cystic fibrosis (CF), a common life-shortening genetic disorder. Early diagnosis via quantitative assessment of sweat chloride allows prompt initiation of care and is critically important to extend life expectancy and improve quality of life. The collection and analysis of sweat using conventional wrist-strapped devices and iontophoresis can be cumbersome, particularly for infants with fragile skin, who often have insufficient sweat production. Here, we introduce a soft, epidermal microfluidic device ("sweat sticker") designed for the simple and rapid collection and analysis of sweat. Intimate, conformal coupling with the skin supports nearly perfect efficiency in sweat collection without leakage. Real-time image analysis of chloride reagents allows for quantitative assessment of chloride concentrations using a smartphone camera, without requiring extraction of sweat or external analysis. Clinical validation studies involving patients with CF and healthy subjects, across a spectrum of age groups, support clinical equivalence compared to existing device platforms in terms of accuracy and demonstrate meaningful reductions in rates of leakage. The wearable microfluidic technologies and smartphone-based analytics reported here establish the foundation for diagnosis of CF outside of clinical settings.
The protective effect of sunscreens, vitamin E 6% cream, and betamethasone 0.1% cream on solar-simulating radiation-induced erythema and neutrophil influx
Authors: Feiko Rijken, Ilse C. Bihari, Kees L.H. Guikers, Huib van Weelden, Piet L.B. Bruijnzeel
Journal: Journal of the American Academy of Dermatology (2013)
FDG PET/CT in 3 Cases of Hypertrophic Pachymeningitis Associated With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis
Authors: Jian Zhang, Yuhan Li, Aisheng Dong, Yuzhao Zhu
Journal: Clinical Nuclear Medicine (2021)

Hypertrophic pachymeningitis associated with antineutrophil cytoplasmic antibody-associated vasculitis is a rare dural inflammatory disorder. We describe MRI and FDG PET/CT findings in 3 cases of hypertrophic pachymeningitis associated with antineutrophil cytoplasmic antibody-associated vasculitis. Enhanced brain MRI of the 3 cases showed linear enhancement of the thickened dura matter involving the skull base, tentorium, and/or convexity. On FDG PET/CT, the thickened dura matter showed diffusely increased FDG uptake with SUVmax ranging from 5.8 to 11.3. Familiarity with these MRI and FDG PET/CT findings is helpful for correct diagnosis and treatment.
Physiologic mechanisms governing hemodynamic responses to positive inotropic therapy in patients with dilated cardiomyopathy.
Authors: K MBorow, R MLang, ANeumann, J DCarroll, S IRajfer
Journal: Circulation (1988)

Clinical trials in patients with dilated cardiomyopathy (DCM) have shown a wide disparity in the hemodynamic responses to positive inotropic therapy. In addition, the response of the failing left ventricle to positive inotropic agents reflects the net interaction of multiple factors, including the magnitude of contractile abnormality and compensatory mechanisms. In the current study, left ventricular geometry, loading conditions, and contractile state were assessed in 13 patients with nonischemic DCM with the use of simultaneous high-fidelity pressure measurements and echocardiographic recordings. Comparisons were made with echocardiographic and calibrated carotid pulse data acquired in nine age-matched normal subjects. The patients with DCM were divided according to the left ventricular end-diastolic wall thickness-to-dimension ratio into groups with appropriate hypertrophy (i.e., less than or equal to 2 SDs from mean normal; n = 5; group 1) and inadequate hypertrophy (i.e., greater than 2 SDs from m...
Signal transduction by G proteins in cardiac tissues.
Authors: J WFleming, P LWisler, A MWatanabe
Journal: Circulation (1992)

The role of G proteins in mediating the responses of the heart to circulating catecholamines and to the influences of the autonomic nervous system is of special interest to cardiologists. It is evident that G proteins are essential links in the cascade of biochemical events that ensure when neurotransmitters and hormones interact with receptors on myocardial cells. It is likely [corrected] that dysfunction of G proteins plays a role in cardiovascular pathophysiology. With current methodologies, especially molecular biological and recombinant DNA techniques, and with transgenic animal models that can relate physiological function and specific gene dosage, some cardiovascular diseases may be traced to G protein-related defects.