tbuckley/cabot-search huggingface dataset:
Application of chitosan-based nanoparticles in skin wound healing
Authors: Hooi Leong Loo, Bey Hing Goh, Learn-Han Lee, Lay Hong Chuah
Journal: Asian Journal of Pharmaceutical Sciences (2022)

The rising prevalence of impaired wound healing and the consequential healthcare burdens have gained increased attention over recent years. This has prompted research into the development of novel wound dressings with augmented wound healing functions. Nanoparticle (NP)-based delivery systems have become attractive candidates in constructing such wound dressings due to their various favourable attributes. The non-toxicity, biocompatibility and bioactivity of chitosan (CS)-based NPs make them ideal candidates for wound applications. This review focusses on the application of CS-based NP systems for use in wound treatment. An overview of the wound healing process was presented, followed by discussion on the properties and suitability of CS and its NPs in wound healing. The wound healing mechanisms exerted by CS-based NPs were then critically analysed and discussed in sections, namely haemostasis, infection prevention, inflammatory response, oxidative stress, angiogenesis, collagen deposition, and wound closure time. The results of the studies were thoroughly reviewed, and contradicting findings were identified and discussed. Based on the literature, the gap in research and future prospects in this research area were identified and highlighted. Current evidence shows that CS-based NPs possess superior wound healing effects either used on their own, or as drug delivery vehicles to encapsulate wound healing agents. It is concluded that great opportunities and potentials exist surrounding the use of CSNPs in wound healing.
Patient and Clinician Perceptions of Factors Relevant to Ideal Specialty Consultations
Authors: Stephanie D. Roche, Anna C. Johansson, Jaclyn Giannakoulis, Michael N. Cocchi, Michael D. Howell, Bruce Landon, Jennifer P. Stevens
Journal: JAMA Network Open (2022)

<h3>Importance</h3> Inpatient subspecialty consultations, a common and expensive practice within inpatient medicine, do not always go well; however, little is known about the failure modes of consultation, thus making it difficult to identify interventions to improve consultation quality. <h3>Objective</h3> To understand how stakeholders envision the ideal inpatient consultation and identify how and why consultations commonly fall short of this ideal. <h3>Design, Setting, and Participants</h3> This qualitative study used in-depth, semistructured interviews collected from April to October 2017 and analyzed from January 2018 to February 2020 using conventional content analysis. The setting was a single academic medical center in Boston, Massachusetts. Participants were hospitalists and specialists who had requested or performed a consultation for a non–intensive care unit patient in the previous 4 months, patients who had received a consultation while hospitalized at the medical center in the previous 15 months, and family members of such patients. <h3>Main Outcomes and Measures</h3> Consultation experiences reported by participants. Clinicians were asked about characteristics of the ideal consultation, positive and negative consultation experiences, costs and benefits, and suggested improvements. Patients and family members were asked about their consultation experience, changes in care, communication preferences, and suggested improvements. <h3>Results</h3> The study included 38 participants: 17 specialists, 13 hospitalists, 4 patients, and 4 family members. More than half (21 of 38) of the participants were female. There were 11 key information exchanges identified that occur among the specialist team, primary team, and patient/family during an ideal consultation. These exchanges are time sensitive and primarily carried out through unwritten protocols. We also identified 6 defects (process failures) that commonly derail information exchanges (complete omission, exclusion of a key stakeholder, poor timing, incomplete or inaccurate information, and misinterpretation) and 5 contextual factors (roles and boundaries, professionalism, team hierarchy, availability, and operational know-how) that influence how information exchange unfolds, making some consultations more prone to defects. <h3>Conclusions and Relevance</h3> Successful inpatient consultation requires a complicated, sequenced series of time-sensitive information exchanges that are highly vulnerable to failure. Maximizing the benefit of consultations will likely entail not only minimizing low-value consultations but also actively preventing defects, such as information inaccuracies and misinterpretation, that commonly derail the consultation process.
Selumetinib in children with neurofibromatosis type 1 and asymptomatic inoperable plexiform neurofibroma at risk for developing tumor-related morbidity
Authors: Andrea M Gross, Brittany Glassberg, Pamela L Wolters, Eva Dombi, Andrea Baldwin, Michael J Fisher, AeRang Kim, Miriam Bornhorst, Brian D Weiss, Jaishri O Blakeley, Patricia Whitcomb, Scott M Paul, Seth M Steinberg, David J Venzon, Staci Martin, Amanda Carbonell, Kara Heisey, Janet Therrien, Oxana Kapustina, Anne Dufek, Joanne Derdak, Malcolm A Smith, Brigitte C Widemann
Journal: Neuro-Oncology (2022)

Abstract Background Selumetinib was recently approved for the treatment of inoperable symptomatic plexiform neurofibromas (PNs) in children with neurofibromatosis type 1 (NF1). This parallel phase II study determined the response rate to selumetinib in children with NF1 PN without clinically significant morbidity. Methods Children with NF1 and inoperable PNs, which were not yet causing clinically significant morbidity but had the potential to cause symptoms, received selumetinib at 25 mg/m2 orally twice daily (1 cycle = 28 days). Volumetric magnetic resonance imaging analysis and outcome assessments, including patient-reported (PRO), observer-reported, and functional outcome measures were performed every 4 cycles for 2 years, with changes assessed over time. A confirmed partial response (cPR) was defined as PN volume decrease of ≥20% on at least 2 consecutive scans ≥3 months apart. Results 72% of subjects experienced a cPR on selumetinib. Participants received selumetinib for a median of 41 cycles (min 2, max 67) at data cutoff. Approximately half of the children rated having some target tumor pain at baseline, which significantly decreased by pre-cycle 13. Most objectively measured baseline functions, including visual, motor, bowel/bladder, or airway function were within normal limits and did not clinically or statistically worsen during treatment. Conclusions Selumetinib resulted in PN shrinkage in most subjects with NF1 PN without clinically significant morbidity. No new PN-related symptoms developed while on selumetinib, and PRO measures indicated declines in tumor-related pain intensity. This supports that selumetinib treatment may prevent the development of PN-related morbidities, though future prospective studies are needed to confirm these results. Clinical Trial registration ClinicalTrials.gov NCT01362803.
Biomimetic glycopeptide hydrogel coated PCL/nHA scaffold for enhanced cranial bone regeneration via macrophage M2 polarization-induced osteo-immunomodulation
Authors: Yaping Wang, Jingrong Wang, Rui Gao, Xiang Liu, Zujian Feng, Chuangnian Zhang, Pingsheng Huang, Anjie Dong, Deling Kong, Weiwei Wang
Journal: Biomaterials (2022)
Evidence-based biomaterials research
Authors: Kai Zhang, Bin Ma, Kaiyan Hu, Bo Yuan, Xin Sun, Xu Song, Zhonglan Tang, Hai Lin, Xiangdong Zhu, Yufeng Zheng, Andrés J. García, Antonios G. Mikos, James M. Anderson, Xingdong Zhang
Journal: Bioactive Materials (2022)
Confirming Effectiveness of Endoscopic Colon Cancer Screening in Inflammatory Bowel Disease: The Puzzle Remains Unsolved?
Authors: Maarten te Groen, Frank Hoentjen
Journal: Clinical Gastroenterology and Hepatology (2022)

Endoscopic surveillance programs to prevent colorectal cancer (CRC) in inflammatory bowel disease (IBD) patients were implemented after initial studies reported an alarmingly high long-term CRC risk.1 Endoscopic surveillance now firmly is embedded in international guidelines and clinical practice but an evidence-based foundation to support this practice did not precede its implementation. To address this gap, Kim et al2 reported on the effectiveness of endoscopic surveillance and CRC outcomes in a large cohort of IBD patients.
Major Concerns Remain With Gestational Weight Gain and Pregnancy Burden—Reply
Authors: Cheryce L. Harrison, Joanne Enticott, Helena J. Teede
Journal: JAMA Internal Medicine (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Lirentelimab for severe and chronic forms of allergic conjunctivitis
Authors: Stephen D. Anesi, Joseph Tauber, Quan Dong Nguyen, Peter Chang, Gregg J. Berdy, Charles C. Lin, David S. Chu, H. Terry Levine, Andrew D. Fernandez, Neeta Roy, Penny A. Asbell, Andrea M. Kantor, Alan T. Chang, Bhupinder Singh, Bradford A. Youngblood, Bennie H. Jeng, Vishal Jhanji, Henrik S. Rasmussen, C. Stephen Foster
Journal: Journal of Allergy and Clinical Immunology (2022)

Allergic conjunctivitis (AC) is an ocular inflammatory disease with symptoms driven by eosinophils and mast cells. Allergic comorbidities are common. Current treatments are often ineffective in severe AC and limited by potential side effects. Lirentelimab is an anti-sialic acid-binding immunoglobulin-like lectin-8 mAb that depletes eosinophils and inhibits mast cells.
Food environment and diabetes mellitus in South Asia: A geospatial analysis of health outcome data
Authors: Dian Kusuma, Petya Atanasova, Elisa Pineda, Ranjit Mohan Anjana, Laksara De Silva, Abu AM Hanif, Mehedi Hasan, Md. Mokbul Hossain, Susantha Indrawansa, Deepal Jayamanne, Sujeet Jha, Anuradhani Kasturiratne, Prasad Katulanda, Khadija I Khawaja, Balachandran Kumarendran, Malay K Mridha, Vindya Rajakaruna, John C Chambers, Gary Frost, Franco Sassi, Marisa Miraldo
Journal: PLoS Medicine (2022)

The global epidemic of type 2 diabetes mellitus (T2DM) renders its prevention a major public health priority. A key risk factor of diabetes is obesity and poor diets. Food environments have been found to influence people's diets and obesity, positing they may play a role in the prevalence of diabetes. Yet, there is scant evidence on the role they may play in the context of low- and middle-income countries (LMICs). We examined the associations of food environments on T2DM among adults and its heterogeneity by income and sex. We linked individual health outcome data of 12,167 individuals from a network of health surveillance sites (the South Asia Biobank) to the density and proximity of food outlets geolocated around their homes from environment mapping survey data collected between 2018 and 2020 in Bangladesh and Sri Lanka. Density was defined as share of food outlets within 300 m from study participant's home, and proximity was defined as having at least 1 outlet within 100 m from home. The outcome variables include fasting blood glucose level, high blood glucose, and self-reported diagnosed diabetes. Control variables included demographics, socioeconomic status (SES), health status, healthcare utilization, and physical activities. Data were analyzed in ArcMap 10.3 and STATA 15.1. A higher share of fast-food restaurants (FFR) was associated with a 9.21 mg/dl blood glucose increase (95% CI: 0.17, 18.24; p < 0.05). Having at least 1 FFR in the proximity was associated with 2.14 mg/dl blood glucose increase (CI: 0.55, 3.72; p < 0.01). A 1% increase in the share of FFR near an individual's home was associated with 8% increase in the probability of being clinically diagnosed as a diabetic (average marginal effects (AMEs): 0.08; CI: 0.02, 0.14; p < 0.05). Having at least 1 FFR near home was associated with 16% (odds ratio [OR]: 1.16; CI: 1.01, 1.33; p < 0.05) and 19% (OR: 1.19; CI: 1.03, 1.38; p < 0.05) increases in the odds of higher blood glucose levels and diagnosed diabetes, respectively. The positive association between FFR density and blood glucose level was stronger among women than men, but the association between FFR proximity and blood glucose level was stronger among men as well as among those with higher incomes. One of the study's key limitations is that we measured exposure to food environments around residency geolocation; however, participants may source their meals elsewhere. Our results suggest that the exposure to fast-food outlets may have a detrimental impact on the risk of T2DM, especially among females and higher-income earners. Policies should target changes in the food environments to promote better diets and prevent T2DM.
Usefulness of gel immersion endoscopy to identify a colonic diverticulum with active bleeding
Authors: Takaaki Kishino, Yoko Kitamura
Journal: Endoscopy (2022)

Management of colonic diverticular bleeding is clinically important because severe cases require transarterial embolization or surgical intervention; colonic diverticular bleeding can cause death in elderly patients with multiple comorbidities [1]. Colonoscopy enables the diagnosis and treatment of the bleeding site; however, identifying the diverticulum with active bleeding is challenging. Gel immersion endoscopy has been reported to be useful for securing the visual field during endoscopy for gastrointestinal bleeding [2] [3]. We report a case in which gel immersion endoscopy was effective in allowing the colonic diverticulum with active bleeding to be identified.
Outcomes of In-Person and Telehealth Ambulatory Encounters During COVID-19 Within a Large Commercially Insured Cohort
Authors: Elham Hatef, Daniel Lans, Stephen Bandeian, Elyse C. Lasser, Jennifer Goldsack, Jonathan P. Weiner
Journal: JAMA Network Open (2022)

<h3>Importance</h3> Since the start of the COVID-19 pandemic, few studies have assessed the association of telehealth with outcomes of care, including patterns of health care use after the initial encounter. <h3>Objective</h3> To assess the association of telehealth and in-person visits with outcomes of care during the COVID-19 pandemic. <h3>Design, Setting, and Participants</h3> This cohort study assessed continuously enrolled members in private health plans of the Blue Cross and Blue Shield Association from July 1, 2019, to December 31, 2020. <h3>Main Outcomes and Measures</h3> Main outcomes were ambulatory encounters per enrollee stratified by characteristics derived from enrollment files, practitioner claims, and community characteristics linked to the enrollee's zip code. Outcomes of care were assessed 14 days after the initial encounters and included follow-up encounters of any kind, emergency department encounters, and hospitalizations after initial telehealth or in-person encounters. <h3>Results</h3> In this cohort study of 40 739 915 individuals (mean [SD] age, 35.37 [18.77] years; 20 480 768 [50.3%] female), ambulatory encounters decreased by 1.0% and the number of in-person encounters per enrollee decreased by 17.0% from 2019 to 2020; however, as a proportion of all ambulatory encounters, telehealth encounters increased substantially from 0.6% (n = 236 220) to 14.1% (n = 5 743 718). For members with an initial telehealth encounter for a new acute condition, the adjusted odds ratio was 1.44 (95% CI, 1.42-1.46) for all follow-ups combined and 1.11 (95% CI, 1.06-1.16) for an emergency department encounter. For members with an initial telehealth encounter for a new chronic condition, the adjusted odds ratios were 0.94 (95% CI, 0.92-0.95) for all follow-ups combined and 0.94 (95% CI, 0.90-0.99) for in-patient admissions. <h3>Conclusions and Relevance</h3> In this cohort study of 40.7 million commercially insured adults, telehealth accounted for a large share of ambulatory encounters at the peak of the pandemic and remained prevalent after infection rates subsided. Telehealth encounters for chronic conditions had similar rates of follow-up to in-person encounters for these conditions, whereas telehealth encounters for acute conditions seemed to be more likely than in-person encounters to require follow-up. These findings suggest a direction for future work and are relevant to policy makers, payers, and practitioners as they manage the use of telehealth during the COVID-19 pandemic and afterward.
Immunogenicity after second and third mRNA-1273 vaccination doses in patients receiving chemotherapy, immunotherapy, or both for solid tumours
Authors: Sjoukje F Oosting, Astrid A M van der Veldt, Rudolf S N Fehrmann, Corine H GeurtsvanKessel, Rob S van Binnendijk, Anne-Marie C Dingemans, Egbert F Smit, T Jeroen N Hiltermann, Gerco den Hartog, Mathilda Jalving, Tatjana T Westphal, Arkajyoti Bhattacharya, Faye de Wilt, Annemarie Boerma, Lisanne van Zijl, Guus F Rimmelzwaan, Pia Kvistborg, Cecile A C M van Els, Nynke Y Rots, Debbie van Baarle, John B A G Haanen, Elisabeth G E de Vries
Journal: The Lancet Oncology (2022)
Nasopharyngeal airway dual-transcriptome of infants with severe bronchiolitis and risk of childhood asthma: A multicenter prospective study
Authors: Zhaozhong Zhu, Carlos A. Camargo, Yoshihiko Raita, Robert J. Freishtat, Michimasa Fujiogi, Andrea Hahn, Jonathan M. Mansbach, Jonathan M. Spergel, Marcos Pérez-Losada, Kohei Hasegawa
Journal: Journal of Allergy and Clinical Immunology (2022)
Bullous pemphigoid: Three main clusters defining 3 outcome profiles
Authors: Florine Guerrois, Elsa Hassan, Thomas Bettuzzi, Vannina Seta, Claire Goulvestre, Lamia Jelti, Thibaut Belmondo, Pierre Wolkenstein, Selim Aractingi, Saskia Ingen-Housz-Oro, Nicolas Dupin
Journal: Journal of the American Academy of Dermatology (2022)
Recognizing Racial Bias and Promoting Diversity in the Rheumatology Workforce
Authors: Siobhan M. Case, Gail S. Kerr, Mia Chandler, Valerie E. Stone, Irene Blanco, Candace H. Feldman
Journal: Arthritis & Rheumatology (2022)

Disclosure Form Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Minimally Invasive Surfactant Therapy vs Sham Treatment and Death or Bronchopulmonary Dysplasia in Preterm Infants With Respiratory Distress Syndrome—Reply
Authors: Peter A. Dargaville, John B. Carlin, Peter G. Davis
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Eligibility Criteria Perpetuate Disparities in Enrollment and Participation of Black Patients in Pancreatic Cancer Clinical Trials
Authors: Andrea N. Riner, Selamawit Girma, Vignesh Vudatha, Nitai Mukhopadhyay, Nevena Skoro, Tamas S. Gal, Devon C. Freudenberger, Kelly M. Herremans, Thomas J. George, Jose G. Trevino
Journal: Journal of Clinical Oncology (2022)

PURPOSE Clinical trials determine safety and efficacy of cancer therapeutics and establish standards of care. Minority patient participation in cancer clinical trials is dismal. We aimed to determine the impact of eligibility criteria on disparities in pancreatic ductal adenocarcinoma (PDAC) clinical trial candidacy. METHODS Traditional PDAC trial eligibility criteria were obtained from ClinicalTrials.gov. Patients with PDAC who sought care at Virginia Commonwealth University Health from 2010 to 2019 were included. Clinical data were obtained from billing codes and discrete values in the electronic medical record. Eligibility criteria differences between racial groups were determined using chi-squared tests and unconditional maximum likelihood-based odds ratios. RESULTS Among 676 patients, most identified as Black or White race (42.5% and 51.6%, respectively). Using traditional criteria, Black patients were more likely to be ineligible for participation compared with White patients (42.4% v 33.2%, P = .023) secondary to hypoalbuminemia (14.1% v 7.9%, P = .023), HIV (3.1% v 0.3%, P = .010), hepatitis B (1.7% v 0%, P = .043), and hepatitis C (9.1% v 3.4%, P = .005). Black patients were also numerically more likely to be ineligible because of renal dysfunction, recent coronary stenting, and uncontrolled diabetes mellitus. Prior cancer treatment excluded fewer Black than White patients (9.1% v 14.0%, P = .072), most attributable to lower rates of neoadjuvant chemotherapy received. Strategic eligibility criteria revisions could equalize ineligibility rates between Black and White patients (26.8% v 24.8%, P = .581). CONCLUSION Traditional eligibility criteria differentially exclude Black patients from participating in PDAC clinical trials. These criteria perpetuate disparities, limit generalizability, and are often not medically justifiable. Revised criteria may improve participant diversity, without compromising safety or study results.
Pediatric Outpatient Prescriptions in Countries With Advanced Economies in the 21st Century
Authors: Marion Taine, Lucile Offredo, Alain Weill, Rosemary Dray-Spira, Mahmoud Zureik, Martin Chalumeau
Journal: JAMA Network Open (2022)

An international comparison of pediatric outpatient prescriptions (POPs) is pivotal to investigate inadequate practices at the national scale and guide corrective actions.
The application of texture and color enhancement imaging in transpapillary biliary cannulation
Authors: Haruka Toyonaga, Toshifumi Kin, Tsuyoshi Hayashi, Kuniyuki Takahashi, Akio Katanuma
Journal: Endoscopy (2022)

The efficacy of image-enhanced endoscopy (IEE) has been widely reported in the management of gastrointestinal tract lesions [1] [2] [3]; however, the efficacy of IEE has not been well discussed in the pancreatobiliary field. Recently, a novel IEE tool called texture and color enhancement imaging (TXI; Olympus, Tokyo, Japan) was launched. TXI has two modes: mode 1, which enhances brightness, texture, and color contrast; and mode 2, which enhances brightness and texture [4]. Herein, we report the usefulness of TXI in biliary cannulation ([Video 1]).