tbuckley/cabot-search huggingface dataset:
Climate-smart Actions in the Operating Theatre for Improving Sustainability Practices: A Systematic Review
Authors: Benjamin Pradere, Richard Mallet, Alexandre de La Taille, Franck Bladou, Denis Prunet, Sarah Beurrier, Florian Bardet, Xavier Game, Georges Fournier, Eric Lechevallier, Paul Meria, Xavier Matillon, Thomas Polguer, Nadia Abid, Bertrand De Graeve, Diana Kassab, Arnaud Mejean, Vincent Misrai, Ugo Pinar
Journal: European Urology (2022)

Surgical activity contributes to global warming though the production of greenhouse gases and consumption of resources. To date, no clinical practice guidelines have been made to promote and implement climate-smart actions. To perform a systematic review of the available actions that could limit CO2 emission in the operating room (OR) and their potential benefits upon the environment, whilst preserving quality of care. MEDLINE and Cochrane databases were searched from January 1, 1990 to April 2021. We included studies assessing carbon footprint (CF) in the OR and articles detailing actions that limit or reduce CF. Thirty-eight studies met the inclusion criteria. We identified six core climate-smart actions: (1) waste reduction by segregation; (2) waste reduction by recycling, reuse, and reprocessing; (3) sterilisation; (4) anaesthesia gas management; and (5) improvement of energy use. Quantitative analysis regarding the CF was not possible due to the lack of homogeneous data. For climate-smart actions, the analysis was limited by discrepancies in study scope and in the methodology of CO2 emission calculation. Improvement of education and awareness was found to have an important impact on waste segregation and reduction. Waste management is the area where health care workers could have the strongest impact, whereas the main field to reduce CF in the OR was found to be energy consumption. This review provides arguments for many climate-smart actions that could be implemented in our daily practice. Improving awareness and education are important to act collectively in a sustainable way. Further studies are mandatory to assess the impact of these climate-smart actions in the OR. We performed a systematic review of the available scientific literature to reference all the climate-smart actions proposed to improve the sustainability of surgical activities. Waste segregation, waste reduction and recycling, reuse and reprocessing, sterilisation, anaesthesia gas changes, and improvement of energy use in the operating room were found to be the main areas of research. There is still a long way to go to homogenise and improve the quality of our climate-smart actions.
Nivolumab Plus Ipilimumab for Previously Treated Stage IV Squamous Cell Lung Cancer—Reply
Authors: Scott Gettinger, Mary W. Redman, Roy S. Herbst
Journal: JAMA Oncology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Health Care Safety during the Pandemic and Beyond — Building a System That Ensures Resilience
Authors: Lee A. Fleisher, Michelle Schreiber, Denise Cardo, Arjun Srinivasan
Journal: New England Journal of Medicine (2022)

Interview with Dr. Lee Fleisher on building a resilient health care delivery system that can maintain high safety levels in times of crisis. (08:30)Download Since the pandemic began, U.S. health care safety has declined severely, suggesting that our system lacks a sufficiently resilient safety culture and infrastructure. We need to build a more resilient delivery system, capable of maintaining high safety levels in crises.
Biohybrid Micro- and Nanorobots for Intelligent Drug Delivery
Authors: Jinhua Li, Lukas Dekanovsky, Bahareh Khezri, Bing Wu, Huaijuan Zhou, Zdenek Sofer
Journal: Cyborg and Bionic Systems (2022)

Biohybrid micro- and nanorobots are integrated tiny machines from biological components and artificial components. They can possess the advantages of onboard actuation, sensing, control, and implementation of multiple medical tasks such as targeted drug delivery, single-cell manipulation, and cell microsurgery. This review paper is to give an overview of biohybrid micro- and nanorobots for smart drug delivery applications. First, a wide range of biohybrid micro- and nanorobots comprising different biological components are reviewed in detail. Subsequently, the applications of biohybrid micro- and nanorobots for active drug delivery are introduced to demonstrate how such biohybrid micro- and nanorobots are being exploited in the field of medicine and healthcare. Lastly, key challenges to be overcome are discussed to pave the way for the clinical translation and application of the biohybrid micro- and nanorobots.
12. Older Adults:<i>Standards of Medical Care in Diabetes—2019</i>
Journal: Diabetes Care (2018)

The American Diabetes Association (ADA) “Standards of Medical Care in Diabetes” includes ADA’s current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, a multidisciplinary expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA’s clinical practice recommendations, please refer to the Standards of Care Introduction. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
P3.03-24 Incorporation of a Molecular Prognostic Classifier Improves Conventional Non-Small Cell Lung Cancer Staging
Authors: G. Haro, J. Kratz, N. Cook, J. He, S. Van Den Eeden, G. Woodard, M. Gubens, T. Jahan, K. Jones, I. Kim, B. He, D. Jablons, M. Mann
Journal: Journal of Thoracic Oncology (2018)
4 Epidemiology and outcome
Journal: Annals of the Rheumatic Diseases (2000)

showed that the presence of damage was positively associated with the SLEDAI score (odds ratio (OR)=1.1,p=0.005), cumulative drug score (OR=1.0,p<0.001), and NPS disease at onset (OR=4.4,p=0.008) and negatively associated with Raynaud phenomenon at onset (OR=0.2,p=0.01).Conclusions-Our results show that permanent damage is common in paediatric onset SLE and is significantly associated with lupus disease activity and cumulative drug treatment.NPS disease at onset is a strong predictor of late damage, whereas the presence of Raynaud phenomenon may exert a protective eVect.
Spirometry forced expiratory time is driven by airflow limitation in asthmatic children
Authors: Jessica Taytard, Marc Koskas, Nicole Beydon
Journal: European Respiratory Journal (2022)

<b>Spirometry forced expiratory time is weakly correlated to age and lung volume, but strongly correlated to airflow limitation that increases it. Consequently, it should significantly decrease in case of significant bronchial reversibility.</b>https://bit.ly/3uG77nd
NCCN Task Force Report: Bone Health in Cancer Care
Authors: Julie R. Gralow, J. Sybil Biermann, Azeez Farooki, Monica N. Fornier, Robert F. Gagel, Rashmi N. Kumar, Charles L. Shapiro, Andrew Shields, Matthew R. Smith, Sandy Srinivas, Catherine H. Van Poznak
Journal: Journal of the National Comprehensive Cancer Network (2009)

Bone health and maintenance of bone integrity are important components of comprehensive cancer care in both early and late stages of disease. Risk factors for osteoporosis are increased in patients with cancer, including women with chemotherapy-induced ovarian failure, those treated with aromatase inhibitors for breast cancer, men receiving androgen-deprivation therapy for prostate cancer, and patients undergoing glucocorticoid therapy. The skeleton is a common site of metastatic cancer recurrence, and skeletal-related events are the cause of significant morbidity. The National Comprehensive Cancer Network (NCCN) convened a multidisciplinary task force on Bone Health in Cancer Care to discuss the progress made in identifying effective screening and therapeutic options for management of treatment-related bone loss; understanding the factors that result in bone metastases; managing skeletal metastases; and evolving strategies to reduce bone recurrences. This report summarizes presentations made at the meeting.
Intracrine activity involving NAD-dependent circadian steroidogenic activity governs age-associated meibomian gland dysfunction
Authors: Lena Sasaki, Yuki Hamada, Daisuke Yarimizu, Tomo Suzuki, Hiroki Nakamura, Aya Shimada, Khanh Tien Nguyen Pham, Xinyan Shao, Koki Yamamura, Tsutomu Inatomi, Hironobu Morinaga, Emi K. Nishimura, Fujimi Kudo, Ichiro Manabe, Shogo Haraguchi, Yuki Sugiura, Makoto Suematsu, Shigeru Kinoshita, Mamiko Machida, Takeshi Nakajima, Hiroshi Kiyonari, Hitoshi Okamura, Yoshiaki Yamaguchi, Takahito Miyake, Masao Doi
Journal: Nature Aging (2022)

Abstract Canonically, hormones are produced in the endocrine organs and delivered to target tissues. However, for steroids, the concept of tissue intracrinology, whereby hormones are produced in the tissues where they exert their effect without release into circulation, has been proposed, but its role in physiology/disease remains unclear. The meibomian glands in the eyelids produce oil to prevent tear evaporation, which reduces with aging. Here, we demonstrate that (re)activation of local intracrine activity through nicotinamide adenine dinucleotide (NAD + )-dependent circadian 3β-hydroxyl-steroid dehydrogenase (3β-HSD) activity ameliorates age-associated meibomian gland dysfunction and accompanying evaporative dry eye disease. Genetic ablation of 3β-HSD nullified local steroidogenesis and led to atrophy of the meibomian gland. Conversely, reactivation of 3β-HSD activity by boosting its coenzyme NAD + availability improved glandular cell proliferation and alleviated the dry eye disease phenotype. Both women and men express 3β-HSD in the meibomian gland. Enhancing local steroidogenesis may help combat age-associated meibomian gland dysfunction.
OBITUARY
Authors: Rupert Waterhouse, John Waterhouse, Gilbert Waterhouse, T Waterhouse, John Hodgson, Waterhouse Writes
Journal: BMJ (1958)

Water Hospital.He was the author of many papers, mainly on rheumatological subjects, and his description of the clinical entity of acute suprarenal insufficiency due to bi- lateral renal haemorrhage was published in 1911; it is now known throughout the world as the Waterhouse-Friderichsen syndrome.A Territorial, Dr. Waterhouse served throughout the first world war in the R.A.M.C. in Gallipoli, Egypt, Palestine, and France.Serving first with the North Somerset Yeo- manry, he commanded the 2nd South-West Mounted Brigade field ambulance for two years, and in 1920 was gazetted to command the 4th Southern General Hospital.When he returned to Bath he practised mainly as a con- sultant in clinical pathology, and at the Annual Meeting of the B.M.A. in 1925 he was vice-president of the Section of Pathology and Bacteriology.Besides his hospital appointments in Bath he was on the staff of several/hospitals in the neighbourhood, including the Victoria Hospital
Rose and Carless' Manual of Surgery
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Images: Voriconazole‐induced synovitis, enthesitis, and periostitis
Authors: Larissa Valor‐Méndez, Jochen Wacker, Georg Schett, Bernhard Manger, Julia Fürst, Richard Strauß, Arnd Kleyer
Journal: Arthritis & Rheumatology (2022)

The patient, a 30-year-old White woman, presented with de novo pain and tenderness affecting hand, elbow, shoulder, knee, and ankle joints. She had been receiving voriconazole for invasive pulmonary and cerebral aspergillosis during the 3 months before presentation. At clinical examination she had discrete synovitis. Laboratory testing revealed normal levels of acute-phase reactants and no rheumatoid factor, anti–citrullinated protein antibodies, or antinuclear antibodies. Radiography of the hands revealed marked osteoproliferation (arrows in A), magnetic resonance imaging showed severe carpal synovitis (arrows in B), and power Doppler ultrasonography detected severe synovitis and enthesitis at the elbows, wrists, and knees. The osteoproliferation zone was also visible by ultrasonography (arrow in C). To quantify the extent of osteoproliferation, we performed high-resolution computed tomography of the wrist, combined with cinematic rendering (a new visualization technique), and detected areas of periosteal proliferation at the distal radius, the distal ulna, and the carpal bones (arrows and box in D). Voriconazole is a triazole antifungal agent recommended as first-line therapy for acute invasive aspergillosis. Toxicities occur in association with supratherapeutic plasma levels of the drug; high plasma fluoride concentrations (1) and alkaline phosphatase levels (2) have also been detected. Because of the high level of inflammatory activity in our patient, we initiated prednisolone therapy, and voriconazole was switched to isavuconazole. Rapid improvement occurred after 2 weeks, prednisolone was suspended after 6 weeks, and the plasma fluoride concentration and alkaline phosphatase level gradually returned to normal. Radiologic and ultrasonography findings were unremarkable within 5 months. In summary, diagnostic images along with clinical findings showed periostitis (3, 4), synovitis, and enthesitis, indicating that voriconazole can trigger the full spectrum of symptoms associated with inflammatory joint disease. In the differential diagnosis of inflammatory joint disease, voriconazole should therefore be considered a trigger of drug-induced arthritis. We thank Dr. Klaus Engel (Siemens Healthineers) for helping to provide computed radiography images and Louis Schuster for technical assistance. Data are available on request. Open access funding enabled and organized by Projekt DEAL. Disclosure Form Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Immunogenicity of a 5‐dose pneumococcal vaccination schedule following allogeneic hematopoietic stem cell transplantation
Authors: Hannah M. Garcia Garrido, Sabine Haggenburg, Marieke C. E. Schoordijk, Ellen Meijer, Michael W. T. Tanck, Mette D. Hazenberg, Caroline E. Rutten, Godelieve J. de Bree, Erfan Nur, Bob Meek, Martin P. Grobusch, Abraham Goorhuis
Journal: American Journal of Hematology (2022)

The optimal schedule of pneumococcal vaccination after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains controversial. The objective of this study was to investigate the immunogenicity of a 5-dose pneumococcal vaccination schedule in adult allo-HSCT recipients with and without immunosuppressive therapy. In this prospective cohort study, allo-HSCT recipients received four doses of the 13-valent pneumococcal conjugate vaccine (PCV13) and one dose of the 23-valent pneumococcal polysaccharide vaccine (PPSV23) starting 4-6 months after allo-HSCT. PCV13 was administered at T0, T1, T2, and T8 (T = months from enrollment) and PPSV23 at T10. Serum was collected at T0, T4, T8, T10, and T12, and IgG levels were measured for all 24 vaccine serotypes by immunoassay. The primary outcome was overall seroprotection at T12 defined as an IgG concentration ≥1.3 μg/ml for 17/24 vaccine serotypes in allo-HCST recipients with and without immunosuppressive therapy at baseline. Secondary outcomes were serotype-specific seroprotection and dynamics of IgG levels. We included 89 allo-HSCT recipients in the final analysis. Overall seroprotection was 47% (15/32) for patients without immunosuppressive therapy at baseline versus 24% (11/46) for patients with immunosuppressive therapy (p = .03). Seroprotection was higher for PCV13 serotypes (78% and 54% respectively; p = .03) and lower for PPSV23-unique serotypes (28% and 13% respectively; p = .1). IgG concentrations increased significantly over time for all 24 serotypes. Concluding, although immunogenicity of PCV13 serotypes was reasonable, the poor response to PPSV23 serotypes resulted in an insufficient overall response to pneumococcal vaccination for allo-HSCT recipients. Research into vaccination strategies with higher-valent T-cell-dependent pneumococcal vaccines is needed.
A microRNA-based liquid biopsy signature for the early detection of esophageal squamous cell carcinoma: a retrospective, prospective and multicenter study
Authors: Jinsei Miyoshi, Zhongxu Zhu, Aiping Luo, Shusuke Toden, Xuantong Zhou, Daisuke Izumi, Mitsuro Kanda, Tetsuji Takayama, Iqbal M. Parker, Minjie Wang, Feng Gao, Ali H. Zaidi, Hideo Baba, Yasuhiro Kodera, Yongping Cui, Xin Wang, Zhihua Liu, Ajay Goel
Journal: Molecular Cancer (2022)

Abstract Background Currently, there is no clinically relevant non-invasive biomarker for early detection of esophageal squamous cell carcinoma (ESCC). Herein, we established and evaluated a circulating microRNA (miRNA)-based signature for the early detection of ESCC using a systematic genome-wide miRNA expression profiling analysis. Methods We performed miRNA candidate discovery using three ESCC tissue miRNA datasets ( n = 108, 238, and 216) and the candidate miRNAs were confirmed in tissue specimens ( n = 64) by qRT-PCR. Using a serum training cohort ( n = 408), we conducted multivariate logistic regression analysis to develop an ESCC circulating miRNA signature and the signature was subsequently validated in two independent retrospective and two prospective cohorts. Results We identified eighteen initial miRNA candidates from three miRNA expression datasets ( n = 108, 238, and 216) and subsequently validated their expression in ESCC tissues. We thereafter confirmed the overexpression of 8 miRNAs (miR-103, miR-106b, miR-151, miR-17, miR-181a, miR-21, miR-25, and miR-93) in serum specimens. Using a serum training cohort, we developed a circulating miRNA signature (AUC:0.83 [95%CI:0.79–0.87]) and the diagnostic performance of the miRNA signature was confirmed in two independent validation cohorts ( n = 126, AUC:0.80 [95%CI:0.69–0.91]; and n = 165, AUC:0.89 [95%CI:0.83–0.94]). Finally, we demonstrated the diagnostic performance of the 8-miRNA signature in two prospective cohorts ( n = 185, AUC:0.92, [95%CI:0.87–0.96]); and ( n = 188, AUC:0.93, [95%CI:0.88–0.97]). Importantly, the 8-miRNA signature was superior to current clinical serological markers in discriminating early stage ESCC patients from healthy controls ( p &lt; 0.001). Conclusions We have developed a novel and robust circulating miRNA-based signature for early detection of ESCC, which was successfully validated in multiple retrospective and prospective multinational, multicenter cohorts.
Toxic Woods
Authors: BRIAN WOODS, C.D. CALNAN
Journal: British Journal of Dermatology (1976)

Eighty-three cases of dermatitis caused by wood or sawdust have been seen at St John's Hospital for Diseases of the Skin, London, in the last 20 years. The clinical details and results of patch tests are reported. The literature on dermatitis, mucosal irritation, asthma and other toxic effects of woods of some 300 botanical species is reviewed at length, with an index of scientific, trade and vernacular names, chemical formulae of the known sensitizing substances, and a table of the 28 toxic woods most often encountered. Pathogenesis, diagnosis and prophylaxis are discussed.
THE ARMY MEDICAL DEPARTMENT.
Journal: JAMA (1907)

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