tbuckley/cabot-search huggingface dataset:
Pentothal Postcards
Authors: Harriet S. Meyer
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NEW YORK HEALTH BOARD FROM A GERMAN VIEWPOINT.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Esophageal Mast cells in Eosinophilic Esophagitis Are Heterogeneous, Dynamically Activated and Locally Proliferate
Authors: Netali Ben-Baruch Morgenstern, Adina Ballaban, Ting Wen, Tetsuo Shoda, Julie Caldwell, Kara Kliewer, Jennifer Felton, Juan Abonia, Vincent Mukkada, Philip Putnam, Scott Bolton, Daniel Dwyer, Nora Barrett, Marc Rothenberg
Journal: Journal of Allergy and Clinical Immunology (2022)
Expansion of a double-negative (CD27-IgD-) B cell population in the sputum of severe eosinophilic asthmatic patients
Authors: Nadia Suray Tan, Manali Mukherjee, Hui Fang Lim, Veronique Angeli, Parameswaran Nair, Sheau Yng Lim, Angeline Rouers, You Yi Hwang, Chung Hwee Thiam, W.S. Daniel Tan, Wupeng Liao, W.S. Fred Wong, Mei Fong Liew, Anis Larbi, Katja Fink, De Yun Wang
Journal: Journal of Allergy and Clinical Immunology (2022)
Glucocorticoid induced adrenal insufficiency
Authors: Marcus Imamovic, Per Dahlqvist, Oskar Ragnarsson, Margret Einarsdottir
Journal: BMJ (2021)

Glucocorticoid-induced adrenal insufficiency is an underdiagnosed condition that possibly contributes to increased mortality. Consensus regarding management of glucocorticoid-induced adrenal insufficiency in patients receiving glucocorticoid therapy has previously been lacking, but the European Society of Endocrinology and the Endocrine Society have recently published joint international guidelines on the diagnosis and treatment, summarized in this article. To further support patients and healthcare professionals, and to prevent a potentially fatal adrenal crisis, a national blue corticosteroid treatment card has been introduced. The card is intended to be provided to patients treated with prednisolone >5 mg daily (or equivalent) for >3-4 weeks.
Tocilizumab: History and Future Perspectives in the Era of COVID-19
Authors: Rina Modha, Stuart Novack
Journal: Journal of Allergy and Clinical Immunology (2022)

Tocilizumab is a recombinant humanized anti-IL-6 receptor antibody that reduces the release of inflammatory cytokines and the risk of cytokine storm. This review describes the history, pharmacokinetics, safety profile, and applications of Tocilizumab as a conventional immunomodulator and critically appraises studies conducted on its use in severe COVID-19. A literature search was conducted in PubMed and Google scholar using specific keywords in English. A curated literature review was done to summarize investigations aimed at evaluating the safety and efficacy of Tocilizumab in severe COVID-19. For inclusion were published observational studies, randomized controlled trials, and studies conducted on human subjects only. For exclusion were studies conducted on animal models, unpublished, or ongoing registered trials. Tocilizumab has a good safety profile that has remained consistent with prior investigations. Initial data describing its efficacy in severe COVID-19 had been mixed due to confounding effects, lack of blinding and placebo controls, and varied study populations with different inclusion and exclusion criteria. Recent large randomized trials including a notable pragmatic study, RECOVERY, were published which concluded that Tocilizumab improved survival in hospitalized patients with severe COVID-19. Tocilizumab has been repurposed for use in severe COVID-19 as a safe immunomodulator preventing cytokine release. At present, the National Institute of Health recommends administering Tocilizumab in patients with severe COVID-19 who meet appropriate criteria. Further peer-reviewed studies are needed to evaluate Tocilizumab use in patients with severe COVID-19 taking other immunomodulating drugs. Additionally, an investigation into the workup and management of “long-haulers” should be conducted.
Current Medical Literature
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Wide Complex QRS During Sotalol Administration
Authors: Albert J. Rogers, Paul J. Wang, Nitish Badhwar
Journal: JAMA Cardiology (2022)

A man in his 40s was seen in clinic for a long history of palpitations. He had a history of cardiac arrest after receiving adenosine for sustained supraventricular tachycardia and tachycardia-induced cardiomyopathy. What would you do next?
Long-Term Anticoagulant Use Studied
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genotype-Based Prediction of Gene Expression in Human Placenta is Associated with Childhood Asthma Susceptibility
Authors: Brittney Snyder, Elizabeth Jasper, Tebeb Gebretsadik, Jacklyn Hellwege, Sarah Jones, Todd Edwards, Carole Ober, Digna Velez Edwards, Tina Hartert
Journal: Journal of Allergy and Clinical Immunology (2022)
Spontaneous Coronary Artery Dissection: New Insights into This Not-So-Rare Condition
Authors: Jennifer Lewey, Stephanie C. El Hajj, Sharonne N. Hayes
Journal: Annual Review of Medicine (2022)

Spontaneous coronary artery dissection (SCAD) is an uncommon but increasingly recognized cause of acute myocardial infarction (MI) among young and middle-aged women and is an important cause of pregnancy-associated MI. Over 90% of SCAD patients are women. Compared to patients with MI caused by atherosclerosis, SCAD patients have fewer cardiovascular risk factors but more often have systemic arteriopathy, most commonly fibromuscular dysplasia. Angiographically, SCAD is characterized by the presence of an intramural hematoma with or without an intimal tear. Accurate recognition of characteristic findings on coronary angiography is critical, as there are important differences in the acute and long-term management of MI caused by SCAD versus atherosclerosis. Acutely, most SCAD patients should be managed conservatively, since percutaneous revascularization is associated with more complications and SCAD-affected vessels usually heal without intervention. Randomized clinical trials and other prospective evaluations are needed, especially to clarify optimal treatment and prevention strategies.
Real-life impact of immunologic tests to predict relapse after treatment cessation in patients with bullous pemphigoid: A French multicenter retrospective study
Authors: Gilles Battesti, Charline Garcia, Manuelle Viguier, Valentine Marchal, Marion Castel, Pascal Joly, Anne-Pham Ledard, Maria-Polina Konstantinou, Vannina Seta, Nadège Cordel, Sophie Duvert-Lehembre, Emmanuelle Tancrède-Bohin, Thibaut Belmondo, Saskia Ingen-Housz-Oro, Michel d'Incan
Journal: Journal of the American Academy of Dermatology (2022)
GMC warns doctors infected with HIV or suffering from AIDS
Journal: BMJ (1987)

are clear about the team's objectives and the individual's role within it. Changing role of nursesThe department has welcomed the interest shown in the concept of a nurse practitioner and intends to look further, in consultation with the professional interests concerned, at such issues as legal status, functions, and qualifications.The department would like to see better use made ofthe talents and skills of all nurses working in the community.On the question of nurses prescribing a limited range of items the department will examine the implications and consult the professional standing advisory committees about the professional and ethical issues.There will be discussions with the professional and academic interests concerned on how to increase the training opportunities ofpractice nurses.
Abstract 635: β <sub>2</sub> -adrenergic Stimulation Compartmentalizes β <sub>1</sub> Signaling Into Nanoscale Local Domains by Targeting the C-terminus of β <sub>1</sub> -adrenoceptors
Authors: Lipeng Wang, Huaqian Yang, Yunyun Gong, Xuexin Fan, Siyu Zhu, Xiaoting Wang, Yupu Wang, Linlin Li, Xin Xing, Xiaoxiao Liu, Guangshen Ji, Tingting Hou, Yan Zhang, Ruiping Xiao, Shiqiang Wang
Journal: Circulation Research (2019)

β-adrenergic receptors (βARs) are prototypical G-protein coupled receptors that play a pivotal role in sympathetic regulation. In heart cells, β 1 R signaling mediates a global cAMP response, regulating both L-type Ca 2+ channels in the sarcolemma/T-tubules (SL/TTs) and ryanodine receptors in the sarcoplasmic reticulum (SR). In contrast, β 2 AR mediates local cAMP signaling with little effect on the function of SR proteins. Accumulating evidence in pathological and transgenic models has suggested a functional complexity of β 2 AR beyond its regulation of L-type Ca 2+ influx. So we investigated the signaling relationship between β 1 ARs and β 2 ARs. Using whole-cell patch clamp combined with confocal calcium imaging, we simultaneously measured L-type Ca 2+ currents and Ca 2+ transients in adult cardiomyocytes. β 1 AR stimulation with norepinephrine or isoproterenol increased both Ca 2+ currents and Ca 2+ transients. β 2 AR stimulation with Zinterol or Salbutamol only increased Ca 2+ currents (onside compartmentalization) and surprisingly inhibited the ability of β 1 AR in upregulating Ca 2+ transients (offside compartmentalization). Further evidence showed that β 2 AR activation recruited G-protein coupled receptor kinase 2 (GRK2) to cell membrane, which phosphorylated the ‘SSES’ serine cluster on β 1 AR carboxyl terminal. Phosphorylated β 1 AR coupled to β-arrestin1 and further recruited phosphodiesterase-4, leading to localized cAMP degradation. Immunocytochemical and biochemical analysis showed the β 2 AR-mediated offside compartmentalization was confined to the nanoscale domain. A knock-in rat model harboring mutations of the three serine residues in ‘SSES’ cluster of the β 1 AR C-terminus, a component of the putative β-arrestin1 binding site and GRK2 phosphorylation site, eliminated the offside compartmentalization conferred by β 2 AR activation. This finding reveals a fundamental “negative feed-forward” mechanism that serves to avoid the cytotoxicity of circulating catecholamine and to sharpen the transient β 1 AR response of sympathetic excitation, providing many potential novel targets for drug discovery against cardiovascular diseases.
Different ways of estimating the amount of individual sun exposure
Journal: British Journal of Dermatology (2022)

Linked article: Souedi et al. Br J Dermatol 2022; 186:266-273. The sun is the main source of exposure people have to ultraviolet radiation (UVR). Sun exposure has some health benefits but also some adverse effects (for example sunburn and skin cancer). Studies about the link between UVR exposure and long-term health outcomes have used a number of different ways to try and accurately measure how much UVR individuals have been exposed to. We set out to study how accurate three different ways of measuring exposure to UVR were over 6 months: (1) ambient UVR levels, (2) self-reported time spent outdoors, and (3) a statistical formula. The participants in this study were employees who worked either indoors or outdoors in Catalunya - Spain during the summer and winter months. Using a wristwatch with a dosimeter (a device made specifically to measure solar UVR levels) we measured each of the participants UVR levels daily during their working hours. Using a statistical formula, we calculated the daily dose of solar UVR each participant received by including their measured levels (from the dosimeter), the general ambient UVR levels of that day, and self-reported time spent outdoors. We then compared the results. Of our 39 participants, not surprisingly, we noted that the levels of UVR were higher for outdoor workers and during the summer. We discovered that the calculated levels and the self-reported time spent outdoors (methods 2 and 3) were more accurate than measuring general ambient UVR levels (method 1) alone. These results will be helpful to researchers who are deciding which are the best methods to use in future studies about the health effects of UVR exposure.
Approaching Data Granularity in Cost-effectiveness Analysis
Authors: Matthew M. McDonough, Jordan D. Dimitrakoff
Journal: JAMA Surgery (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
MISCELLANEA MEDICA
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Metabolic Inflammation and Insulin Resistance in Obesity
Authors: Huaizhu Wu, Christie M. Ballantyne
Journal: Circulation Research (2020)

Obesity is becoming an epidemic in the United States and worldwide and increases risk for many diseases, particularly insulin resistance, type 2 diabetes mellitus, and cardiovascular disease. The mechanisms linking obesity with these diseases remain incompletely understood. Over the past 2 to 3 decades, it has been recognized that in obesity, inflammation, with increased accumulation and inflammatory polarization of immune cells, takes place in various tissues, including adipose tissue, skeletal muscle, liver, gut, pancreatic islet, and brain and may contribute to obesity-linked metabolic dysfunctions, leading to insulin resistance and type 2 diabetes mellitus. Therapies targeting inflammation have shed light on certain obesity-linked diseases, including type 2 diabetes mellitus and atherosclerotic cardiovascular disease, but remain to be tested further and confirmed in clinical trials. This review focuses on inflammation in adipose tissue and its potential role in insulin resistance associated with obesity.
Ligelizumab Achieves Freedom from Signs and Symptoms of Chronic Spontaneous Urticaria Regardless of the CU Index (Basophil Histamine Release Assay) Status at Baseline
Authors: Karl Sitz, Jonathan Bernstein, Weily Soong, Marcus Maurer, Ana Maria Giménez-Arnau, Eva Hua, Thomas Severin
Journal: Journal of Allergy and Clinical Immunology (2022)
Seasonality Associated With Preterm Birth—Are We Borrowing From Our Children?
Authors: David B. Nelson, Catherine Y. Spong
Journal: JAMA Network Open (2022)

Anders Hviid, DrMedSci; Anna Laksafoss, MSc; Paula Hedley, PhD; Ulrik Lausten-Thomsen, PhD; Henrik Hjalgrim, DrMedSci; Michael Christiansen, DrMedSci; Sjurdur Frodi Olsen, DrMedSci
The Anti-KIT Antibody, CDX-0159, Reduces Mast Cell Numbers and Circulating Tryptase and Improves Disease Control in Patients with Chronic Inducible Urticaria (Cindu)
Authors: Dorothea Terhorst-Molawi, Tomasz Hawro, Eva Grekowitz, Lea Kiefer, Martin Metz, Diego Alvarado, Thomas Hawthorne, Kunal Merchant, Linda Crew, Elizabeth Crowley, Margo Heath-Chiozzi, Marcus Maurer
Journal: Journal of Allergy and Clinical Immunology (2022)
Severely impaired CTL killing is a feature of the neurological disorder Niemann-Pick disease type C1
Authors: Daniela Castiblanco, Jesse A. Rudd-Schmidt, Tahereh Noori, Vivien R. Sutton, Ya Hui Hung, Thijs W. H. Flinsenberg, Adrian W. Hodel, Neil D. Young, Nicholas Smith, Drago Bratkovic, Heidi Peters, Mark Walterfang, Joseph A. Trapani, Amelia J. Brennan, Ilia Voskoboinik
Journal: Blood (2022)
802-4 Care of Acute Myocardial Infarction by Non-invasive and Invasive Cardiologists: Procedure Use, Cost, and Outcome
Authors: Thomas G. Di Salvo, Sumita D. Paul, Conrad A. Smith, Michael I. Miyamoto, Donald LIoyd-Jones, Kim A. Eagle, Patrick T. O’Gara
Journal: Journal of the American College of Cardiology (1995)
Omega-3 polyunsaturated fatty acids: moving towards precision use for prevention and treatment of colorectal cancer
Authors: Joanna Aldoori, Andrew J Cockbain, Giles J Toogood, Mark A Hull
Journal: Gut (2022)

Data from experimental studies have demonstrated that marine omega-3 polyunsaturated fatty acids (O3FAs) have anti-inflammatory and anticancer properties. In the last decade, large-scale randomised controlled trials of pharmacological delivery of O3FAs and prospective cohort studies of dietary O3FA intake have continued to investigate the relationship between O3FA intake and colorectal cancer (CRC) risk and mortality. Clinical data suggest that O3FAs have differential anti-CRC activity depending on several host factors (including pretreatment blood O3FA level, ethnicity and systemic inflammatory response) and tumour characteristics (including location in the colorectum, histological phenotype (eg, conventional adenoma or serrated polyp) and molecular features (eg, microsatellite instability, cyclooxygenase expression)). Recent data also highlight the need for further investigation of the effect of O3FAs on the gut microbiota as a possible anti-CRC mechanism, when used either alone or in combination with other anti-CRC therapies. Overall, these data point towards a precision approach to using O3FAs for optimal prevention and treatment of CRC based on mechanistic understanding of host, tumour and gut microbiota factors that predict anticancer activity of O3FAs.