Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk
Authors: Walter C. Willett, Meir J. Stampfer, Frank M. Sacks
Journal: Annals of Internal Medicine (2014)

Letters16 September 2014Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary RiskWalter C. Willett, MD, DrPH, Meir J. Stampfer, MD, DrPH, and Frank M. Sacks, MDWalter C. Willett, MD, DrPHFrom Harvard School of Public Health, Boston, Massachusetts.Search for more papers by this author, Meir J. Stampfer, MD, DrPHFrom Harvard School of Public Health, Boston, Massachusetts.Search for more papers by this author, and Frank M. Sacks, MDFrom Harvard School of Public Health, Boston, Massachusetts.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L14-5018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We appreciate that Chowdhury and colleagues (1) have corrected some of the gross errors in their original paper. Of note, the inverse association of intake of long-chain ω-3 polyunsaturated fatty acids (PUFAs) with cardiovascular disease (CVD) risk is now significant. We also appreciate the sensitivity analysis showing that with exclusion of the outlying SDHS (Sydney Diet Heart Study), the included randomized, controlled trials (RCTs) show benefit of replacing saturated fatty acids (SFAs) with PUFAs. The extreme diet used in that study was never recommended or consumed in the United States. It included a trans fat–based margarine and ...References1. Chowdhury R, Warnakula S, Kunutsor S, Crowe F, Ward HA, Johnson L, et al. Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis. Ann Intern Med. 2014;160:398-406. [PMID: 24723079] doi:10.7326/M13-1788 LinkGoogle Scholar2. Jakobsen MU, O’Reilly EJ, Heitmann BL, Pereira MA, Bälter K, Fraser GE, et al. Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies. Am J Clin Nutr. 2009;89:1425-32. [PMID: 19211817] doi:10.3945/ajcn.2008.27124 CrossrefMedlineGoogle Scholar3. Laaksonen DE, Nyyssönen K, Niskanen L, Rissanen TH, Salonen JT. Prediction of cardiovascular mortality in middle-aged men by dietary and serum linoleic and polyunsaturated fatty acids. Arch Intern Med. 2005;165:193-9. [PMID: 15668366] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Harvard School of Public Health, Boston, Massachusetts.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L14-0319. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAssociation of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Rajiv Chowdhury , Samantha Warnakula , Setor Kunutsor , Francesca Crowe , Heather A. Ward , Laura Johnson , Oscar H. Franco , Adam S. Butterworth , Nita G. Forouhi , Simon G. Thompson , Kay-Tee Khaw , Dariush Mozaffarian , John Danesh , and Emanuele Di Angelantonio Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Rajiv Chowdhury , Samantha Warnakula , Setor Kunutsor , Francesca Crowe , Heather A. Ward , Laura Johnson , Oscar H. Franco , Adam S. Butterworth , Nita G. Forouhi , Simon G. Thompson , Kay-Tee Khaw , Dariush Mozaffarian , John Danesh , and Emanuele Di Angelantonio Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Christine Dawczynski , Marcus E. 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Brouwer , and Daan Kromhout Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Adrienne O’Neil and Catherine Itsiopoulos Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Emanuele Di Angelantonio , Rajiv Chowdhury , Nita G. Forouhi , and John Danesh Metrics Cited byOleogels as Animal Fat and Shortening Replacers: Research Advances and Application ChallengesHealthy diets as a guide to responsible food systemsDietary intake and biomarkers of linoleic acid and mortality: systematic review and meta-analysis of prospective cohort studiesLow-Level Saturated Fatty Acid Palmitate Benefits Liver Cells by Boosting Mitochondrial Metabolism via CDK1-SIRT3-CPT2 CascadeThe big fat debateDietary Fat and Risk of Cardiovascular Disease: Recent Controversies and AdvancesContemporary issues regarding nutrition in cardiovascular rehabilitationDiet, lipids, and cardiovascular diseaseLow Carbohydrate Diets and Type 2 Diabetes: What is the Latest Evidence?Saturated Fats Versus Polyunsaturated Fats Versus Carbohydrates for Cardiovascular Disease Prevention and TreatmentNew Insights or Confusion—Is Butter Really Back?Nut consumption, serum fatty acid profile and estimated coronary heart disease risk in type 2 diabetes 16 September 2014Volume 161, Issue 6Page: 453KeywordsCardiovascular diseasesDietFatsFatty acidsHeartLongitudinal studiesLow density lipoproteinPopulation statisticsRelative riskRisk management ePublished: 16 September 2014 Issue Published: 16 September 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. 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