tbuckley/cabot-search huggingface dataset:
Abstract 207: Dissemination of Hands-Only Cardiopulmonary Resuscitation and the Impact on the Outcome in School Students and Young Adults After Out-of-Hospital Cardiac Arrest of Presumed Cardiac Origin: A Japanese Nationwide Utstein Registry Study
Authors: Yoshihide Mitani, Noriko Yodoya, Hiroyuki Ohashi, Hirofumi Sawada, Masahiro Hirayama
Journal: Circulation (2018)

Introduction: Out-of-hospital cardiac arrests (OHCA) of presumed cardiac origin witnessed by nonfamily members in the daytime are most effectively resuscitated in the youth, in which the impact of recently disseminated hands-only cardiopulmonary resuscitation (CPR) is poorly understood. Hypothesis: Dissemination of hands-only CPR is associated with the better outcome in school students and young adults after such OHCA. Methods: We investigated OHCA of presumed cardiac origin in the youth (Group A, 7-12y; group B, 13-18y; group C, 19-22y; group D, 23-35y) which are witnessed by nonfamily members in the daytime (6:00-17:59) during 2005-15 by using Japanese nationwide Utstein registry. Results: We recruited 1,646 pts, in which N of pts was 92 (A), 382 (B), 229 (C) and 943 (D); ventricular fibrillation (VF) as the initial rhythm (%) was 48, 70, 64, and 59; bystander’s CPR (%) was 81, 80, 71 and 68; hands-only/bystander’s CPR (%) was 32, 38, 57, 56; bystander’s automated external defibrillator (AED) (%) was 37, 44, 24 and 19; the favorable neurological outcome at 1 month (CPC1-2)(%) was 46, 49, 39 and 30. Compared with group D, %bystander’s CPR (p=.013 in A, &lt;.001 in B), %bystander’s AED (&lt;.001 in both), and %CPC1-2 (.005, &lt;.001) was higher but %hands-only CPR(&lt;.001 in both) was lower in A and B, independent of the calendar year. Compared with 2005-09, %hands-only CPR, %bystander’s AED and CPC1-2 were higher in all age groups (&lt;.005 in all) in 2010-15. In multivariate logistic analysis (gender, age groups (vs D), CPR type (conventional or hands-only CPR vs no CPR), bystander’s AED, the initial VF, emergency response time, calendar year), hands-only CPR (p=.03), bystander’s AED(&lt;.001), female gender(.045), initial VF (&lt;.001), emergency response time (&lt;.001), and calendar year (&lt;.001) were independently associated with CPC1-2. Conclusions: The present investigation demonstrates that resuscitation and outcome parameters after OHCA of presumed cardiac origin were persistently better in school students than young adults and that %hands-only CPR, which was persistently lower in school students, was independently associated with the better outcome in the youth overall. This finding may give a clue to further improvement of the outcomes in school students after OHCA.
Correction: Pre-existing antitherapeutic antibodies against the Fc region of the hu14.18K322A mAb are associated with outcome in patients with relapsed neuroblastoma
Authors: Lambros Tselikas, Thierry de Baere, Thomas Isoardo, Sandrine Susini, Karine Ser-Le Roux, Mélanie Polrot, Mathieu Rouanne, Laurence Moine
Journal: Journal for ImmunoTherapy of Cancer (2020)

Correction: Pre-existing antitherapeutic antibodies against the Fc region of the hu14.18K322A mAb are associated with outcome in patients with relapsed neuroblastoma
The PET tracer [ <sup>11</sup> C]MK-6884 quantifies M4 muscarinic receptor in rhesus monkeys and patients with Alzheimer’s disease
Authors: Wenping Li, Yuchuan Wang, Talakad G. Lohith, Zhizhen Zeng, Ling Tong, Robert Mazzola, Kerry Riffel, Patricia Miller, Mona Purcell, Marie Holahan, Hyking Haley, Liza Gantert, David Hesk, Sumei Ren, John Morrow, Jason Uslaner, Arie Struyk, Jenny Miu-Chun Wai, Michael T. Rudd, David M. Tellers, Thomas McAvoy, Guy Bormans, Michel Koole, Koen Van Laere, Kim Serdons, Jan de Hoon, Ruben Declercq, Inge De Lepeleire, Maria B. Pascual, Paolo Zanotti-Fregonara, Meixiang Yu, Victoria Arbones, Joseph C. Masdeu, Amy Cheng, Azher Hussain, Tjerk Bueters, Matt S. Anderson, Eric D. Hostetler, Anthony S. Basile
Journal: Science Translational Medicine (2022)

[ 11 C]MK-6884 is an M4R-specific PET tracer for quantifying target engagement in brain and providing insights into AD neuropathology.
England's NIHP: self-sabotage ahead of bumpy months?
Authors: None The Lancet Microbe
Journal: The Lancet Microbe (2020)

With the southern hemisphere's winter coming to an end, its countries have reported a milder than average influenza season. But are these reports enough to reassure the northern hemisphere, now approaching the onset of autumn, that it might see a similar pattern of decreased transmission of seasonal respiratory viruses and avoid a much-feared double epidemic of COVID-19 and influenza?
Abstract 17414: Increased Activity of Brain Region Governing Stress Perception is Associated With Plaque Vulnerability and Vascular Inflammation in Acute Myocardial Infarction Population; Retrospective and Prospective Study Evaluated by <sup>18</sup> FDG-PET/CT and OCT
Authors: Eun Jin Park, Jae Seon Eo, Won-Young Jang, Dong Oh Kang, Cheol Ung Choi, Eung Ju Kim, Seung-Woon Rha, Chang Gyu Park, Hong Seog Seo, Jin Won Kim
Journal: Circulation (2018)

Backgrounds: Chronic mental stress is a major risk factor of coronary artery disease, but there is a lack of direct mechanistic evidence between brain amygdala activity, a neural stress center, versus plaque vulnerability in acute coronary syndrome. In this study, we aimed to evaluate whether brain amygdala activity in AMI patients assessed by 18 F-FDG PET/CT could be associated with vascular inflammation in carotid beds and high-risk coronary plaque features evaluated by OCT. Methods and Results: In retrospective analysis, the patients who underwent 18 F-FDG PET/CT and CAG at Korea University Guro Hospital (Seoul, Korea). Among 1802 patients underwent 18 F-FDG PET/CT from October 1 2009 to 31 December 31 2015, 230 patients received CAG. After excluding 36 patients who had active cancer or brain disease, 198 were stratified according to degree of coronary severity by syntax score [none (n=159); mild to moderate (n=26); severe (n=13)]. Brain amygdalar activity on PET was quantified as target-to-background ratio (TBR) of standardized uptake value (amygdalar SUV max /temporal SUV mean ). The amygdalar TBR was significantly higher in patients with severe coronary disease rather than those without coronary stenosis or mild to moderate stenosis assessed by syntax score (P=0.03). Intriguingly, among 13 patients with severe CAD, the amygdalar TBR significantly increased in the 6 patients presented as AMI compared to non-MI patients (P=0.03). In following prospective study, we performed 18 F-FDG PET/CT in AMI patients underwent percutaneous coronary intervention within index admission period, and in patients with chronic stable angina (CSA) as control. The plaque morphology in non-culprit segment of infarct-related artery (IRA) was estimated by OCT in AMI patients. Brain amygdalar TBR was significantly higher in AMI patients compared to CSA patients (p&lt;0.05). In AMI patients, amygdalar activity was significantly associated with vascular inflammation quantified as carotid TBR (p&lt;0.05). The increased amygdalar activity was associated with high-risk plaque characteristics of non-culprit segments of IRA. Conclusions: The amygdalar activity assessed by 18 F-FDG PET/CT was significantly higher in patients with AMI than CSA. This amygdalar activity was related to vulnerable plaque characteristics of IRA. Our results suggest that brain emotional activity in ACS could contribute to plaque instability in pan-vascular beds.
Acute Tetrachloroethylene Intoxication
Authors: Richard D. Stewart
Journal: JAMA (1969)

A workman wearing a chemical respirator was discovered unconscious in a tank car shortly after he had entered to clean it with the solvent, tetrachloroethylene. Infrared analysis of his breath revealed a high concentration of tetrachloroethylene and showed he had been exposed to an anesthetic vapor concentration inside his respirator. The analysis indicated the probable diagnosis from a long list of possible causes of unconsciousness. The brief, but acute vapor exposure caused mild chemical hepatitis over the next ten days.
Real-world timelines of BRCA1/2-related molecular testing in pancreatic cancer.
Authors: Weiyan Li, Suvina Amin, Seongjung Joo, Gboyega Adeboyeje, Patricia DeArbeloa, Emanuel Petricoin, Edik Matthew Blais, Michael J. Pishvaian
Journal: Journal of Clinical Oncology (2022)

601 Background: BRCA1/2 mutations are present in ̃6-8% of patients with pancreatic adenocarcinoma. Olaparib is a recently approved PARP inhibitor (PARPi) in the US and Europe for germline BRCA1/2-mutated metastatic PaC in the 1st line maintenance setting following response to at least 16 weeks of a platinum-containing regimen. However, the availability of BRCA1/2 testing results at the time of 1st line and subsequent treatment decisions in the advanced stage has not been established in real-world settings. Methods: Longitudinal clinical/molecular data collected between 1/2012-12/2020 were retrospectively analyzed in 75 PaC pts with germline or somatic BRCA1/2 mutations (BRCA1/2m) who enrolled in Perthera’s US real-world observational registry. Tumor NGS testing results were generated by commercial labs for all patients. Germline status was assessed by a molecular tumor board when testing results are available. BRCA1/2m discovery timing (days since advanced presentation), molecular testing turnaround time (days from physician order to result), and platinum utilization were abstracted from physician records. Associations between BRCA1/2m discovery timing and platinum utilization were evaluated using Fisher’s exact test. Results: At the time of advanced PaC diagnosis, BRCA1/2m status was known in a minority of patients (29% (22 of 75). In the remaining 71% (53 of 75) patients, the median time to report BRCA1/2m status was 76 days (IQR=56-558) following advanced diagnosis. The median tumor NGS testing turnaround time was 35 days after physician order (IQR=24-54). Platinum use in any setting was documented in 85% (64 of 75) of patients and the majority of these patients (62%, 40 of 64) initiated a platinum-based regimen before BRCA1/2m status was first reported. Platinum agents were initiated before 2nd line in 75% (48 of 64) patients, and this was associated with BRCA1/2m identification before advanced diagnosis (p=0.03). Conclusions: BRCA1/2 testing results may not always be available when 1st line regimens are chosen which can impact ideal treatment sequencing in PaC patients. These real-world analyses underscore the importance of upfront BRCA1/2 testing in PaC patients.
HLF regulates ferroptosis, development and chemoresistance of triple-negative breast cancer by activating tumor cell-macrophage crosstalk
Authors: Hengyu Li, Pinghua Yang, JingHan Wang, Jin Zhang, Qianyun Ma, Yingjie Jiang, Yani Wu, Tao Han, Daimin Xiang
Journal: Journal of Hematology & Oncology (2022)

Abstract Tumor-associated macrophages (TAMs) are major components of the tumor microenvironment (TME) which are closely associated with the tumor malignant progression. However, the regulatory mechanisms by which TAMs influence the progression of triple-negative breast cancer (TNBC) remain unclear. Here, we report that hepatic leukemia factor (HLF) acts as a novel oncoprotein in TNBC. We found that HLF was regulated by transforming growth factor-beta1 (TGF-β1) that is secreted by TAMs. Then, HLF transactivated gamma-glutamyltransferase 1 (GGT1) to promote the ferroptosis resistance, thus driving TNBC cell proliferation, metastasis and cisplatin resistance. Reciprocally, IL-6 produced by TNBC cells activated the JAK2/STAT3 axis to induce TGF-β1 secretion by TAMs, thus constituted a feed-forward circuit. The accuracy of TNBC patient prognosis could be improved by employing a combination of HLF and GGT1 values. Thus, our findings document that the interactive dialogue between TNBC cells and TAMs promotes sustained activation of HLF in tumor cells through the IL-6-TGF-β1 axis. Subsequently, HLF promotes the ferroptosis resistance in TNBC cells via GGT1 and ultimately facilitates the malignant tumor progression. Our study provides a potential target for the treatment of TNBC.
1303P Lorlatinib for advanced ALK+ non-small cell lung cancer (NSCLC): Efficacy and safety data from IFCT-1803 LORLATU expanded access program (EAP) cohort
Authors: S. Baldacci, B. Besse, V. Avrillon, B. Mennecier, P. Dubray-Longeras, J. Mazieres, R. Descourt, M. Duruisseaux, X. Quantin, H. Doubre, I. Monnet, D. Moro-Sibilot, S. Schneider, S. Cousin, P. Merle, J. Otto, A. Langlais, F. Morin, V. Westeel, N. Girard
Journal: Annals of Oncology (2020)
Commentary
Authors: Klaus Mönkemüller
Journal: Endoscopy (2020)

Insertion of multiple plastic stents into the bile duct may result in migration of the initially placed stent during insertion of the subsequent stent. Migration of plastic stents is a particular problem in patients with altered anatomy as handling of the scope in such cases is more complicated, and attempts to remove the migrated stent may lead to ERCP failure. Therefore, the double-wire stent-antimigration technique presented by Kachi et al. is of important endoscopic value for several reasons: (a) it increases our armamentarium of techniques to prevent stent migration during deployment; (b) it shows a case of extreme ERCP in a patient with altered anatomy; and (c) the technique may also be applied during routine ERCP in patients with intact anatomy.
On Septicaemia
Authors: J. R. Kealy
Journal: BMJ (1885)

SHIP BRITWH AMM' ) RNAL. IO7By this; you will see 'that oX! Aprilw22nd he kad got up tora fair average, both as regards petoentage; and quantity passed; aad this upon a diet containing,as little nitrogen as possible.On MIay 26th, however, you will note that the percentage had decreased to .54, and the total am'ount' to -12&: grains..This is accounted for in this way; during the five we'eks' interval, I had been unable to prevail upon him to send up his urine for examination, because he did not like to trouble me ; he had lost twosisters by death, and had experi- enced severe family home-worries as well; at last I prevailed upon him to let me have another specimen for examination, with the result mentioned.During all this time the Hollands was taken every night, but the appetite had been a' little more indulged, especially with eggs.He was told to take his old mixture again, and you will see that by the end of the week, notwithstanding -that the amount of urine had de- creased to 30 ounces, the percentage had increased to 1.82, and the total urea to 16.24 grammes, or 249.1 grains.CASE ii.-Mrs.SD., a visitor, aged 76, has always enjoyed most robust health, and been a brilliant member of society.She had eaten meat in' large quantities until the present time, when she usually ate
Dr. Mary Putnam is Not Dead.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Marriages
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases
Authors: Deobrat Dixit, Briana C. Prager, Ryan C. Gimple, Tyler E. Miller, Qiulian Wu, Shira Yomtoubian, Reilly L. Kidwell, Deguan Lv, Linjie Zhao, Zhixin Qiu, Guoxin Zhang, Derrick Lee, Donglim Esther Park, Robert J. Wechsler-Reya, Xiuxing Wang, Shideng Bao, Jeremy N. Rich
Journal: Science Translational Medicine (2022)

DPY30 is an in vivo–specific dependency in glioblastoma that regulates phosphodiesterases and angiogenesis in the hypoxic tumor microenvironment.
Perioperative nivolumab monotherapy versus nivolumab plus ipilimumab in resectable hepatocellular carcinoma: a randomised, open-label, phase 2 trial
Authors: Ahmed Omar Kaseb, Elshad Hasanov, Hop Sanderson Tran Cao, Lianchun Xiao, Jean-Nicolas Vauthey, Sunyoung S Lee, Betul Gok Yavuz, Yehia I Mohamed, Aliya Qayyum, Sonali Jindal, Fei Duan, Sreyashi Basu, Shalini S Yadav, Courtney Nicholas, Jing Jing Sun, Kanwal Pratap Singh Raghav, Asif Rashid, Kristen Carter, Yun Shin Chun, Ching-Wei David Tzeng, Divya Sakamuri, Li Xu, Ryan Sun, Vittorio Cristini, Laura Beretta, James C Yao, Robert A Wolff, James Patrick Allison, Padmanee Sharma
Journal: The Lancet. Gastroenterology & hepatology (2022)

Hepatocellular carcinoma has high recurrence rates after surgery; however, there are no approved standard-of-care neoadjuvant or adjuvant therapies. Immunotherapy has been shown to improve survival in advanced hepatocellular carcinoma; we therefore aimed to evaluate the safety and tolerability of perioperative immunotherapy in resectable hepatocellular carcinoma.
Tiny RNAs associated with transcription start sites in animals (vol 41, pg 572, 2009)
Authors: RJ Taft, EA Glazov, N Cloonan, C Simons, S Stephen, GJ Faulkner, T Lassmann, Arr Forrest, SM Grimmond, K Schroder, K Irvine, T Arakawa, M Nakamura, A Kubosaki, K Hayashida, C Kawazu, M Murata, H Nishiyori, S Fukuda, J Kawai, CO Daub, DA Hume, H Suzuki, Orlando, P Carninci, Y Hayashizaki, JS Mattick
Journal: Nature Genetics (2009)
'What's in a name?' The Paperwork Reduction Act
Authors: M. E. DeBakey
Journal: JAMA (1990)

"Paperwork Reduction Act." Music to the ears of every American taxpayer. And certainly to physicians inundated by Medicare forms. Who could oppose legislation with such a noble name? Well, I could. Not because I advocate paperwork proliferation, but because a proposal within the House of Representatives to renew this Act (first enacted in 1980) contains a clause that would damage an institution that most physicians have long depended on for reliable information—the National Library of Medicine (NLM). This institution represents the largest and finest collection of biomedical publications, papers, and documents in the world. The quality of information products derived from the Library's databases will be at serious risk if HR 3695, The Paperwork Reduction and Federal Information Resources Management Act of 1989, is enacted. This Act, sponsored by Rep John Conyers, Jr, of Michigan, would prohibit the Library from entering into formal agreements with private vendors, thus effectively banning
Front &amp; Back Matter
Authors: Abu Minhajuddin, Michael E. Thase, Robin B. Jarrett, Felice N. Jacka, Julie A. Pasco, Lana J. Williams, Neil Mann, Allison Hodge, Laima Brazionis, Michael Berk, Louise Sharpe, Leslie Schrieber, Ulla-Sisko Lehto, Markku Ojanen, Tadeusz Dyba, Arpo Aromaa, Pirkko Kellokumpu-Lehtinen, Søren Dinesen Østergaard, Anthony J. Rothschild, Peter Uggerby, Povl Munk-Jørgensen, Per Bech, Ole Mors, Jasper A.J. Smits, Guey-Mei Jow, Wen-Hung Kuo, King-Jen Chang, Yu-Fen Liu, Rainbow T.H. Ho, Siu-Man Ng, Cecilia L.W. Chan, Yu-Ming Lai, Yu-Ting Chen, Fei-Hsiu Hsiao, Lisa Cosgrove, Allen F. Shaughnessy, Emily E. Wheeler, Kirsten E. Austad, Irving Kirsch, Harold J. Bursztajn, Vedat Sar, Warwick Middleton, Martin J. Dorahy, V. Peus, E. Redelin, B. Scharnholz, T. Paul, P. Gass, P. Deuschle, F. Lederbogen, M. Deuschle, Katja Beesdo-Baum, Andrew T. Gloster, Susanne Knappe, Michael Höfler, Volker Arolt, Jürgen Deckert, Alexander L. Gerlach, Alfons Hamm, Tilo Kircher, Thomas Lang, Jan Richter, Andreas Ströhle, Peter Zwanzger, Hans-Ulrich Wittchen, Angela Emmrich, Guy A. Boysen, Craig Steel, Nicholas Tarrier, Daniel Stahl, Til Wykes, Satz Mengensatzproduktion, Druck Reinhardt Druck Basel, Druck Reinhardt Druck Basel
Journal: Psychotherapy and Psychosomatics (2012)
Lawsuits for malpractice
Authors: Leonard Berlin
Journal: JAMA (1978)

<h3>To the Editor.—</h3> Mr Vaccarino's perspective on malpractice may be quite correct in the milieu of Massachusetts General Hospital, but it fails to explain what is happening in the community hospital. Here there is a long-established and close rapport between attending physician and patient, and there are no residents or interns to complicate the physician-patient relationship, yet there is an extremely high incidence of malpractice suits. Therefore, I believe "the most significant contributive factor to frivolous claims" is<i>not</i>"the poor relationship with the provider" but rather the litigiousness of the patient coupled with a plaintiff's lawyer who is all too willing to file any kind of malpractice suit, regardless of its merits. However, even assuming that some suits are filed simply because the patient is disgruntled with his physician, is not that the fault of the attorney? Should not a lawyer, who is, after all, an expert in the
TCT-693 Multicentre clinical study evaluating a novel resheathable self-expanding transcatheter aortic valve system
Authors: Axel Linke, Ganesh Manoharan, Helge Moellmann, Ulrich Schäfer, Jan Kovac, Karl-Heinz Kuck, David M. Holzhey, Thomas Walther
Journal: Journal of the American College of Cardiology (2015)
Verbals
Authors: L. S. King
Journal: JAMA (1968)

Repeatedly in this series we have emphasized the importance of verbs—"action words." Most commonly they exert a declarative function, to serve as "predicate." That is, in a clause (whether independent or dependent), the verb asserts some action or state relative to the subject. "He ran" is a sentence in which "he" is the subject, "ran" the predicate. Or, "After he ran, he rested." "Ran" is the predicate of the dependent clause, "rested" of the independent clause. However, verbs have many forms and many functions. Forms which we designate as "verbals"—infinitives and gerunds and gerundives—serve functions that are not predicates. For example, "After exercising, he decided to rest." "Exercising" is a participial form used as a noun, the object of the preposition "after." Participial forms used as nouns are called "gerunds." In this same sentence, "to rest" is an infinitive, also functioning as a noun, the object of "decided." If the