Agranulocytosis Induced by Nonchemotherapy Drugs
Authors: Luisa Ibáñez, Xavier Vidal, Joan-Ramon Laporte
Journal: Annals of Internal Medicine (2008)

Letters19 February 2008Agranulocytosis Induced by Nonchemotherapy DrugsLuisa Ibáñez, PhD, MD, Xavier Vidal, PhD, MD, and Joan-Ramon Laporte, PhD, MDLuisa Ibáñez, PhD, MDFrom Clinical Pharmacology Service, Vall d'Hebron Hospital, Universitat Autònoma, Fundació Institut Català de Farmacología, 08035 Barcelona, Spain.Search for more papers by this author, Xavier Vidal, PhD, MDFrom Clinical Pharmacology Service, Vall d'Hebron Hospital, Universitat Autònoma, Fundació Institut Català de Farmacología, 08035 Barcelona, Spain.Search for more papers by this author, and Joan-Ramon Laporte, PhD, MDFrom Clinical Pharmacology Service, Vall d'Hebron Hospital, Universitat Autònoma, Fundació Institut Català de Farmacología, 08035 Barcelona, Spain.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-4-200802190-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their recent interesting article, Andersohn and colleagues (1) present a systematic review of case reports of drugs definitely or probably related to agranulocytosis. However, the definition of a plausible time relationship to drug administration includes the onset of acute agranulocytosis occurring within 1 month after treatment withdrawal. This definition could lead to a misclassification of drug causality because agranulocytosis is mainly an immunologic disorder, and a drug is unlikely to induce the disorder if it or its metabolites are not present in the body (2). This could have led to an overall misclassification of drug causality ...References1. Andersohn F, Konzen C, Garbe E. Systematic review: agranulocytosis induced by nonchemotherapy drugs. Ann Intern Med. 2007;146:657-65. [PMID: 17470834] LinkGoogle Scholar2. Kaufman DW, Kelly JP, Levy M, Shapiro S. The Drug Etiology of Agranulocytosis and Aplastic Anemia. New York: Oxford Univ Pr; 1991. Google Scholar3. Ibáñez L, Vidal X, Ballarín E, Laporte JR. Population-based drug-induced agranulocytosis. Arch Intern Med. 2005;165:869-74. [PMID: 15851637] CrossrefMedlineGoogle Scholar4. Beauchesne MF, Shalansky SJ. Nonchemotherapy drug-induced agranulocytosis: a review of 118 patients treated with colony-stimulating factors. Pharmacotherapy. 1999;19:229-305. CrossrefGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Clinical Pharmacology Service, Vall d'Hebron Hospital, Universitat Autònoma, Fundació Institut Català de Farmacología, 08035 Barcelona, Spain.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSystematic Review: Agranulocytosis Induced by Nonchemotherapy Drugs Frank Andersohn , Christine Konzen , and Edeltraut Garbe Agranulocytosis Induced by Nonchemotherapy Drugs Sherif B. Mossad Agranulocytosis Induced by Nonchemotherapy Drugs Sridhar Mani Agranulocytosis Induced by Nonchemotherapy Drugs Frank Andersohn , Christine Konzen , and Edeltraut Garbe Agranulocytosis Induced by Nonchemotherapy Drugs Chaker Ben Salem , Raoudha Slim , Houssem Hmouda , and Kamel Bouraoui Metrics 19 February 2008Volume 148, Issue 4Page: 319-320KeywordsDrugsEpidemiologyHematopoietic growth factorsMetabolitesNeutrophilsRisk managementSulfonamideSystematic reviewsThrombocytosis ePublished: 19 February 2008 Issue Published: 19 February 2008 CopyrightCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...