tbuckley/cabot-search huggingface dataset:
LAW &amp;amp; MEDICINE
Authors: Angela Roddey Holder
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Deutsche Medizinische Wochenschrift, Stuttgart
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Efficacy and safety of carvedilol in severe heart failure patients accepted for heart transplantation Christiane E. Angermann, Angelika Costard-Jaeckle, Mario C. Deng, for the EFICAT-Trial study group. Medical Clinic (Innenstadt) of the University, Munich, Germany, Cardiothoracic Clinics of the Universities Kiel, Muenster, Germany
Journal: Journal of the American College of Cardiology (2001)
Abstract P322: The Association Between Parity and Sleep Duration: a Study From the AHA Go Red for Women Strategically Focused Research Network (SFRN)
Authors: Natalie A Bello, Janet Catov, Brooke Aggarwal
Journal: Circulation (2017)

Background: Prior research has shown a J shaped association between parity and increased risk of cardiovascular disease (CVD), and several confounding factors have been identified. Sleep is emerging as an important, potentially modifiable risk factor for CVD, however few data have examined the relationship between parity and sleep. Methods: We studied 50 women in the AHA Go Red for Women Strategically Focused Research Network who provided information on pregnancy history and sleep patterns [56% non-white (n=28), mean age = 41±18 y]. The Pittsburgh Sleep Quality Index was used to assess sleep duration and quality, and the Insomnia Severity Index was used to assess level of insomnia. Parity was assessed using a standardized questionnaire as any pregnancies lasting &gt; 6 mo. We used linear and logistic regression to examine the cross-sectional relation between sleep (duration, quality, and insomnia severity) and parity. Results: Prior pregnancy was reported in 32% (16 of 50) women and 36% (18 of 50) sleep ≤ 6 h/night. Parous women were significantly older (55 vs 34 y), more likely to have a BMI ≥25 kg/m 2 , HTN, and hyperlipidemia compared to nulliparous women. Sleep duration was significantly shorter in parous women (6 h vs 7 h), and the relationship remained significant for primiparous women (1 birth) after adjustment ( Figure ). More than half of parous women reported poor sleep quality (56%, 9 of 16) and insomnia (63%, 10 of 16) compared to 29% of nulliparous women (10 of 34) who reported each sleep disorder. After adjustment for age, there was no difference in sleep quality or insomnia between groups (p&gt;0.05). Conclusion: In a diverse cohort of women, sleep duration was inversely related to parity. Primiparous women may be at heightened risk for the adverse cardiometabolic consequences of inadequate sleep duration, and may represent a teachable moment for CVD prevention. Ongoing studies to examine the relationship between sleep and pregnancy may provide important information on the pathways through which these risk factors modify future CVD.
The journey of neutropoiesis: how complex landscapes in bone marrow guide continuous neutrophil lineage determination
Authors: Celine Overbeeke, Tamar Tak, Leo Koenderman
Journal: Blood (2022)

Neutrophils are the most abundant white blood cell, and they differentiate in homeostasis in the bone marrow from hematopoietic stem cells (HSCs) via multiple intermediate progenitor cells into mature cells that enter the circulation. Recent findings support a continuous model of differentiation in the bone marrow of heterogeneous HSCs and progenitor populations. Cell fate decisions at the levels of proliferation and differentiation are enforced through expression of lineage-determining transcription factors and their interactions, which are influenced by intrinsic (intracellular) and extrinsic (extracellular) mechanisms. Neutrophil homeostasis is subjected to positive-feedback loops, stemming from the gut microbiome, as well as negative-feedback loops resulting from the clearance of apoptotic neutrophils by mature macrophages. Finally, the cellular kinetics regarding the replenishing of the mature neutrophil pool is discussed in light of recent contradictory data.
Is 6 months of plavix enough to prevent late total occlusion after gamma radiation for in-stent restenosis? Ron Waksman, Andrew E. Ajani, Han-Soo Kim, Roxana Mehran, Alexandra J. Lansky, Regina Deible, Maeve Taaffe, Gary S. Mintz, Lowell F. Satler, Kenneth M. Kent, Augusto D. Pichard. Washington Hospital Center, Washington, DC
Journal: Journal of the American College of Cardiology (2001)
SOCIETY NEWS.
Authors: A. O. Wright
Journal: JAMA (1894)

<h3>The Second Sanitary Convention of the State of California.</h3> -The second annual Sanitary Convention will be held at San José on April 16, the day preceding the meeting of the State Medical Society. The convention will be held under the auspices of the State Board of Health, which will pay all the bills. Invitation is extended to all medical men and sanitarians to be present and to present papers in the interest of preventive measures.—<i>Pacific Medical Journal</i>. <b>The Morgan County (Illinois) Medical Society</b>held its regular monthly meeting in the Society's rooms, Jacksonville, March 8; President Frank P. Norbury in the chair. C. E. Ruth, Professor of Anatomy and Clinical Surgery, Keokuk (Iowa) Medical College, by special invitation demonstrated, upon a dog, the use of the "Murphy button " in intestinal surgery. The meeting was well attended. A vote of thanks was tendered Prof. Ruth for his highly interesting and
Clinical Electroencephalography
Authors: Rosalie J. Ging
Journal: JAMA (1973)

Kiloh and Osselton have maintained the excellent quality of their work in this third edition. It has been enhanced especially by the contributions of Professor McComas on basic neurophysiology. His chapters on the role of the thalamus and the location of the electroencephalographic pacemaker were especially interesting. After the chapters on neuroanatomy and neurophysiology there follows a description of procedures, techniques, and the normal adult and childhood records. The chapters on epilepsy, head injury, and space-occupying lesions are covered in a clear, concise way. The section on head injury included thoughtful discussion of sequelae and electroencephalographic and clinical interpretation of residuals. This basic information has been written with clarity so that a clinician can integrate his grasp of neuroanatomy and neurophysiological principles. Inclusion of data from research studies have maintained the value of such a book for internists, psychiatrists, and neurologists. References to recent studies are conveniently available. There are
Transcatheter arterial chemoembolization therapy in combination strategy with lenvatinib in patients with unresectable hepatocellular carcinoma (TACTICS-L) in Japan: Final analysis.
Authors: Kazuomi Ueshima, Toru Ishikawa, Issei Saeki, Naoki Morimoto, Hiroshi Aikata, Nobukazu Tanabe, Yoshitaka Inaba, Yoshiyuki Wada, Yasuteru Kondo, Masahiro Tsuda, Kazuhiko Nakao, Masafumi Ikeda, Michihisa Moriguchi, Takanori Ito, Masahiro Kobayashi, Hironori Koga, Keisuke Hino, Yoshiyuki Suzuki, Kenichi Yoshimura, Masatoshi Kudo
Journal: Journal of Clinical Oncology (2022)

417 Background: Treatment options for hepatocellular carcinoma (HCC) include surgical resection, percutaneous ablation therapy, transcatheter arterial chemoembolization (TACE), and liver transplantation, etc., and TACE is indicated for unresectable HCC (uHCC) that is not eligible for curative therapy. Combination therapy with TACE and molecular targeted agents has been reported to have higher antitumor efficacy than respective monotherapies. This study aims to evaluate safety and efficacy of combination of TACE and lenvatinib in uHCC patients. Methods: Phase II, prospective, multicenter, single-arm study was conducted in 19 Japanese sites. Lenvatinib was administered orally once daily for 14 to 21 days prior to TACE at a dose of 12 mg (body weight ≥60 kg) or 8 mg (&lt; 60 kg). The first TACE was performed after a 2-day lenvatinib withdrawal period. This combination therapy was repeated until the time to untreatable progression (TTUP). The primary endpoint was progression-free survival (PFS). Secondary endpoints included TTUP, objective response rate (ORR), overall survival (OS), and safety. Results: Between February 2019 and April 2020, 62 patients were enrolled. Median age was 72.0 years (&lt; 65 years, 13 [21.0%]; ≥65 years, 49 [79.0%]). Number of patients with Child-Pugh score 5 and 6 was 51 (82.3%) and 11 (17.7%); Eastern Cooperative Oncology Group Performance Status 0 and 1 was 59 (95.2%) and 3 (4.8%); and Barcelona Clinic Liver Cancer Stage A and B was 25 (40.3%) and 37 (59.7%). The number of previous TACE procedures was 0 in 35 patients (56.5%) and 1 to 3 in 27 patients (43.5%). The estimated median PFS, OS, and TTUP were more than 2 years. The ORR was 88.7% (90% CI 79.8 – 94.6 with complete response (CR) rate of 66.1%). Treatment emergent adverse events (AEs) occurred in 98.4% of patients, and the most common AEs were hypothyroidism (58.1%), hypertension (53.2%), decreased appetite (50.0%), and fatigue (48.4%). Grade 3 and 4 AEs occurred in 71.0% and 4.8%, and serious AEs occurred in 40.3%. One death not causally related to the protocol treatment was observed. Conclusions: In this final analysis, the combination of TACE and lenvatinib showed promising therapeutic efficacy in patients with uHCC. No new safety signal was observed. Future phase III studies are required to validate this combination therapy. Clinical trial information: jRCTs031180074.
Continuing medical education
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Covid-19: Brazilian artist celebrates life in death
Authors: Alison Shepherd
Journal: BMJ (2022)

This installation in São Paulo by the Brazilian artist Siron Franco entitled Renascimento, or Rebirth, pays tribute to the more than 620 000 people who have died from covid-19 in the country.Composed of 365 suspended mannequins, the work also honours Brazil's health professionals, who are facing a huge surge in cases caused by the omicron variant of SARS-CoV-2, with 69 010 new daily cases on 14 January, up from 22 626 a week earlier. 1 The true figures are likely to be much higher as a cyberattack on the health ministry last month has limited the collection of data from state health authorities.Despite the figures, and unlike previous waves, omicron has not caused Brazil's health system to collapse, thanks in part to 67% of adults now being fully vaccinated.1
Effect of Fractional Carbon Dioxide Laser vs Sham Treatment on Vaginal Symptom Severity in Postmenopausal Women—Reply
Authors: Fiona G. Li, Erin Nesbitt-Hawes, Jason A. Abbott
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Miscellanea Medica
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
B-mode ultrasound imaging of arterial walls in FH-children, FH-adults and controls shows the need for atherosclerosis prevention in individuals at high risk for cardiovascular disease Eric de Groot, Albert Wiegman, Willem F. Terpstra, Marianne E. Wittekoek, Johan Gort, Henk D. Bakker, Jo F. May, Andries J. Smit, John J. P. Kastelein. Academic Medical Centre, Vascular Medicine, Amsterdam, The Netherlands
Journal: Journal of the American College of Cardiology (2001)
Adaptive anxiety
Authors: None The Lancet Planetary Health
Journal: The Lancet Planetary Health (2020)

Human societies have evolved dramatically over the past few hundred years such that we might expect change to be something we are all well equipped to handle, and even embrace. To some extent that is true, but clearly much depends on how things change, how well those changes fit with our personal, social, and national narratives, and how quickly these changes occur. Perspectives on change are also influenced by how it affects the material wellbeing of individuals. Predictability is a further important factor.
GW26-e0766 Effects of Mesenchymal Stem Cell Transplantation on the Ventricular Fibrillation Threshold in Rats with Myocardial Infarction in Short-Term, Medium-Term and Long-Term Period
Authors: Fei Wang, Shaoxin Zheng, Huibao Long, Tianzhu Guo, Tong Wang
Journal: Journal of the American College of Cardiology (2015)
Lymphogranuloma Venereum Mimicking Lymphoma on FDG PET/CT
Authors: Angeliki N. Georgopoulou, Evangelia Skoura, Eleftheria Lakiotaki, Nikolaos V. Sipsas, Theodoros P. Vassilakopoulos
Journal: Clinical Nuclear Medicine (2022)

A 42-year-old man presented with painless, left inguinal lymphadenopathy, which was suspicious of malignant lymphoma. Multiple left-sided foci of markedly increased metabolic activity were observed on PET/CT (SUVmax up to 22.3), located at the inguinal, iliac, and para-aortic lymph nodes along with small-sized right inguinal lymphadenopathy. Laboratory tests revealed increased inflammation markers and neutrophilic leukocytosis. Pathological examination from dissected inguinal lymph node was consistent with granulomatous disease. Infection by chlamydia trachomatis was made serologically establishing the diagnosis of lymphogranuloma venereum.
The State: An Ecological Phenomenon
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A phase 3 randomized, double-blind, placebo-controlled, multicenter, global study of durvalumab with and after chemoradiotherapy in patients with locally advanced, unresectable esophageal squamous cell carcinoma: KUNLUN.
Authors: Luhua Wang, Ming Chen, Ken Kato, Lucjan Wyrwicz, Elizabeth Catherine Smyth, Anastasia Jiang, Di Zhang, Scott H. Robbins, Philip He, Alejandra Negro, Nabil F. Saba
Journal: Journal of Clinical Oncology (2022)

TPS373 Background: Esophageal cancer is the eighth most common cancer type and the sixth leading cause of cancer-related death worldwide, and esophageal squamous cell carcinoma (ESCC) is the most common type of esophageal cancer. For patients with locally advanced, unresectable ESCC (AJCC 8th Stage II–IVA), definitive chemoradiotherapy (dCRT) is the current standard of care; however, up to half of patients will experience disease progression within two years of dCRT, and overall survival rates remain suboptimal. The combination of immune checkpoint inhibitors with CRT has demonstrated synergistic antitumor activity in pre-clinical models, and recent clinical data has demonstrated clinical benefit of combined programmed cell death-1 inhibition and preoperative CRT in patients with locally advanced ESCC. KUNLUN (NCT04550260) is a Phase 3, multicenter, global study evaluating the efficacy and safety of durvalumab, a programmed cell death ligand-1 (PD-L1) inhibitor, given concurrently with, and after, dCRT in patients with locally advanced, unresectable ESCC. Methods: Approximately 600 patients will be randomized 2:1 to receive either durvalumab with dCRT (cisplatin plus fluorouracil or cisplatin plus capecitabine, with a total dose of 50–64 Gy radiation), followed by durvalumab for up to approximately 24 months, or placebo with dCRT, followed by placebo for up to approximately 24 months. Eligible patients will have histologically or cytologically confirmed ESCC, and present with locally advanced, unresectable ESCC that is deemed suitable for dCRT. Patients must have an Eastern Cooperative Oncology Group performance status of 0 or 1, and have not received prior anti-cancer treatment. The co-primary endpoint of the study is progression-free survival according to RECIST v1.1 as assessed by blinded independent central review in all randomized patients and in patients with PD-L1-high tumors. Additional endpoints include overall survival and safety. Study enrollment is ongoing. Funding: This study was sponsored by AstraZeneca. References: Hong MH, et al. J Clin Oncol 2019;37(15 suppl). Abs 4027. Clinical trial information: NCT04550260.
Transcriptional, Protein-Level and Functional Profiling of Human Fetal Liver (FL)-Derived Hematopoietic Stem Cells (HSCs) at Single Cell Resolution
Authors: Kim Vanuytsel, Carlos Villacorta-Martin, Jonathan Lindstrom-Vautrin, Zhe Wang, Wilfredo Garcia Beltran, Taylor Matte, Todd W Dowrey, Vannesa Mengze Li, Ruben Dries, Joshua D Campbell, Anna C Belkina, Alejandro Balazs, George J Murphy
Journal: Blood (2020)