tbuckley/cabot-search huggingface dataset:
A Clot‐Homing Near‐Infrared Probe for In Vivo Imaging of Murine Thromboembolic Models
Authors: Dan Chen, Peiwen Liu, Yurong Liu, Zhiyou Wang, Yang Zhou, Longguang Jiang, Cai Yuan, Yongkun Li, Wei Lin, Mingdong Huang
Journal: Advanced Healthcare Materials (2022)

Abstract Direct thrombus imaging contributes to early detection of thrombosis, and animal models with clinical relevance are vital in the development of new thrombolytics. Here, a facile clot‐homing strategy is developed based on the finding that blood clot is negatively charged. Positively charged pentalysine moiety is coupled with phthalocyanine‐based fluorophore , and its applications in murine thromboembolic models are described. The probe efficiently stains the cryosection of intracranial thrombi retrieved from patients with cardioembolic stroke. In vitro, the fibrin‐rich clot is labeled by the probe at sub‐nanomolar concentration. The probe‐labeled clot is formed into microparticles (1–5 µm) and intravenously injected into mice for pulmonary embolism modeling. In vivo imaging demonstrates fast accumulation and retention of fluorescent clot microparticles in pulmonary vessels. Recombinant tissue‐type plasminogen activator (rtPA) administration greatly reduces near‐infrared signal in the lungs in a time‐dependent manner. This probe is also tested in a stroke model. Middle cerebral artery is occluded by autologous thrombi formed under electric stimulation. In vivo imaging shows that the probe efficiently homes to thrombus at early stage. Hence, this probe has great potential in real‐time imaging of thromboembolism in clinically relevant models, promoting bench‐to‐bedside translation. This clot‐homing principle can be used in other applications.
Expansion of interferon-gamma-producing Th1 lymphocytes as a mechanism of progression in acute coronary syndromes J�rg Koglin, Heiko Methe, Stefan Brunner, Daniela Wiegand, Wolfgang von Scheidt. Medizinische Klinik 1, Universit�tsklinikum Grosshadern, Munich, Germany
Journal: Journal of the American College of Cardiology (2001)
Insomnia
Authors: Eliza L. Sutton
Journal: Annals of Internal Medicine (2021)

Insomnia-the unwelcome experience of difficulty sleeping-is common and can be acute, intermittent, or chronic. Insomnia can be the presenting symptom for several common sleep disorders, but it also often occurs comorbidly with mental and physical health conditions. Evaluating the symptom of insomnia requires assessing-largely by history-whether an underlying condition explains it. Insomnia disorder is the diagnostic term for the symptom of insomnia that merits specific attention. Cognitive behavioral therapy for insomnia is the preferred treatment approach because of its efficacy, safety, and durability of benefit, but pharmaceutical treatments are widely used for insomnia symptoms.
Advisory Board and Contents
Authors: Tara Van Viegen, Athena Akrami, Kathryn Bonnen, Eric Dewitt, Alexandre Hyafi, Helena Ledmyr, Grace Lindsay, Patrick Mineault, John Murray, Xaq Pitkow, Aina Puce, Madineh Sedigh-Sarvestani, Carsen Stringer, Titipat Achakulvisut, Elnaz Alikarami, Melvin Atay, Eleanor Batty, Jeffrey Erlich, Byron Galbraith, Yueqi Guo, Ashley Juavinett, Matthew Krause, Songting Li, Marius Pachitariu, Elizabeth Straley, Davide Valeriani, Emma Vaughan, Maryam Vazi Ri -Pashkam, Michael Waskom, Gunnar Blohm, Konrad Kording, Paul Schrater, Brad Wyble, Sean Escola, Megan Peters, Benjamin Lecorps, Daniel Weary, Marina Von Keyserlingk, Quentin Moreau, Guillaume Dumas, Giacomo Novembre, Gian Iannetti, Tobias Grossmann, Kevin Weiner, Jesse Gomez, Lindsey Drayton, Jessica Miles, Rolf Van Der Sanden, Patrick Scheffmann, Ralph Adolphs, Renee Baillargeon, Nick Chater, Peter Dayan, Stanislas Dehaene, Daniel Dennett, Yadin Dudai, Andreas Engel, Martha Farah, Angela Friederici, Okihide Hikosaka, Ray Jackendoff, Philip Johnson-Laird, Nancy Kanwisher, Christof Koch, Marta Kutas, Nikos Logothetis, James Mcclelland, Earl Miller, Elizabeth Phelps, Russell Poldrack, Marcus Raichle, Trevor Robbins, Anthony Wagner, Vincent Walsh
Journal: Trends in Cognitive Sciences (2021)
Archives of Dermatology, Chicago
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Liver Transplant for Alcohol-Associated Liver Disease
Authors: Bo-Han Zhang, Yun-Shi Cai, Jia-Yin Yang
Journal: JAMA Surgery (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Relationship between tensile stress and plaque growth after balloon angioplasty followed by intracoronary radiation Ken Kozuma, Marco A. Costa, Manel Sabate, Cornelis J. Slager, Eric Boersma, Patrick Kay, Johannes P. A. Marijnissen, Stephane G. Carlier, Jolanda J. Wentzel, Attila Thury, Jurgen M. R. Ligthart, Veronique L. M. A. Coen, Peter C. Levendag, Patrick W. Serruys. Thoraxcenter, Rotterdam, The Netherlands, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
Journal: Journal of the American College of Cardiology (2001)
Notes on Some German Universities
Authors: W. K. Sibley
Journal: BMJ (1889)

THIs picturesque old city has passed through many phases of change during the last few centuries.At one time under French, at other times under German rule, it has survived the conflict of many antagonistic principles.But in its present period of peace- ful progress it opens the doors of its University to all who wish to study any of the branches of learning.The University buildings are the finest in Germany.The present University was founded by the late Emperor Wilhelm I, in 1872, the laboratories being con- structed with all the most modern improvements.The Town Hospital is, however, a very old one, and one of the most picturesque buildings in Strassburg.The chief buildings are situated on the east side of the town, and consist of a magnificent central block, the Collegienhaus, with its halls, large public rooms, and sculpture gallery, together with a large, well-fitted readingroom, containing papers and periodicals of all nations, including all our own magazines of any standing, whether literary or scientific. in 2~~~~~~~.
THE USE OF SMALL ENEMAS IN CONSTIPATION
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum
Journal: BMJ (1893)

HEALTH DEPARTmENT.-We shall be much obliged to Medical Officers of Health if they will, on forwarding their Annual and other Reports, favour us with duplicate copies." Queries, answers, and communication8 relating to 8ubject8 to which special departments of the BRITISH MEDICAL JOURNAL are devoted will be found under their respective headings.QIERIES.MICROsCOPE asks to be recommend a useful microscope, moderate in price (five or six guineas), and a small manual on practical microscopic working ?
<i>Twelve Lectures on the Structure of the Central Nervous System, for Physicians and Students.</i>By Dr. Ludwig Edinger, Franklorton-the-Mann. Second revised edition, with 133 illustrations. Translated by Willis Hall Vittum, M. D., St. Paul, Minn. Edited by C. Eugene Riggs, A. M., M. D., Professor of Mental and Nervous Diseases, University of Minnesota; Member of the American Neurological Association. Phiiladelphia and Lodon: F. A. Davis, Publisher, 1890. 8vo: pp. xii, 230
Journal: American Journal of Psychiatry (1891)
Insertion/Deletion polymorphism of angiotensin I?Converting enzyme gene and risk of restenosis after directional coronary atherectomy followed by stent implantation Massimiliano Gnecchi, Maurizio Ferrario, Alessandra Repetto, Umberto Canosi, Ezio Bramucci, Luigi Angoli, Maria Luisa Laudisa, Francesco Bernardi, Piera Angelica Merlini, Diego Ardissino. IRCCS, Policlinico S. Matteo, Pavia, Italy, Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy
Journal: Journal of the American College of Cardiology (2001)
Use of 68Ga-FAPI PET/CT for Detecting Myeloid Sarcoma of the Breast and Assessing Early Response to Chemotherapy
Authors: Simin Wu, Zhijuan Lin, Qihang Shang, Yizhen Pang, Haojun Chen
Journal: Clinical Nuclear Medicine (2022)

Abstract Myeloid sarcoma is a rare presentation of acute myeloid leukemia as a solid tumor at various extramedullary sites. In this case, we report 18 F-FDG and 68 Ga-FAPI PET/CT findings in an 18-year-old woman with biopsy-proven myeloid sarcoma involving the left breast. 68 Ga-FAPI PET/CT showed a far better tumor-to-background contrast than 18 F-FDG PET/CT in the left breast mass. Moreover, follow-up 68 Ga-FAPI PET/CT after 2 cycles of chemotherapy revealed a reduction in tumor size with decreasing activity in the myeloid sarcoma lesions.
Correction: Accuracy of novel antigen rapid diagnostics for SARS-CoV-2: A living systematic review and meta-analysis
Journal: PLoS Medicine (2021)

The third bullet under the "What did the researchers do and find?" section of the Author Summary is incorrect.The publisher apologizes for this error.The correct text is: Across all meta-analyzed studies, when Ag-RDTs were performed according to manufacturers' recommendations, they showed a sensitivity of 76.3% (95% CI 73.1% to 79.2%), with LumiraDx (sensitivity 88.2% [95% CI 59.0% to 97.5%]) and, of the instrument-free Ag-RDTs, Standard Q nasal (80.2% sensitivity [95% CI 70.3% to 87.4%]) performing best.
Modulation of the HIF2α-NCOA4 axis in enterocytes attenuates iron loading in a mouse model of hemochromatosis
Authors: Nupur K. Das, Chesta Jain, Amanda Sankar, Andrew J. Schwartz, Naiara Santana-Codina, Sumeet Solanki, Zhiguo Zhang, Xiaoya Ma, Sanjana Parimi, Liangyou Rui, Joseph D. Mancias, Yatrik M. Shah
Journal: Blood (2022)
Fenofibrate Mitigates Hypertriglyceridemia in Nonalcoholic Steatohepatitis Patients Treated With Cilofexor/Firsocostat
Authors: Eric J. Lawitz, Bal Raj Bhandari, Peter J. Ruane, Anita Kohli, Eliza Harting, Dora Ding, Jen-Chieh Chuang, Ryan S. Huss, Chuhan Chung, Robert P. Myers, Rohit Loomba
Journal: Clinical Gastroenterology and Hepatology (2022)

Patients with advanced fibrosis due to nonalcoholic steatohepatitis (NASH) are at high risk of morbidity and mortality. We previously found that a combination of the farnesoid X receptor agonist cilofexor (CILO) and the acetyl-CoA carboxylase inhibitor firsocostat (FIR) improved liver histology and biomarkers in NASH with advanced fibrosis but was associated with hypertriglyceridemia. We evaluated the safety and efficacy of icosapent ethyl (Vascepa) and fenofibrate to mitigate triglyceride elevations in patients with NASH treated with CILO and FIR.Patients with NASH with elevated triglycerides (≥150 and <500 mg/dL) were randomized to Vascepa 2 g twice daily (n = 33) or fenofibrate 145 mg daily (n = 33) for 2 weeks, followed by the addition of CILO 30 mg and FIR 20 mg daily for 6 weeks. Safety, lipids, and liver biochemistry were monitored.All treatments were well-tolerated; most treatment-emergent adverse events were Grade 1 to 2 severity, and there were no discontinuations due to adverse events. At baseline, median (interquartile range [IQR]) triglycerides were similar in the Vascepa and fenofibrate groups (median, 177 [IQR, 154-205] vs 190 [IQR, 144-258] mg/dL, respectively). Median changes from baseline in triglycerides for Vascepa vs fenofibrate after 2 weeks of pretreatment were -12 mg/dL (IQR, -33 to 7 mg/dL; P = .09) vs -32 mg/dL (IQR, -76 to 6 mg/dL; P = .012) and at 6 weeks were +41 mg/dL (IQR, 16-103 mg/dL; P < .001) vs -2 mg/dL (IQR, -42 to 54 mg/dL; P = .92). In patients with baseline triglycerides <250 mg/dL, fenofibrate was more effective vs Vascepa in mitigating triglyceride increases after 6 weeks of combination treatment (+6 vs +39 mg/dL); similar trends were observed in patients with baseline triglycerides ≥250 mg/d (-61 vs +99 mg/dL).In patients with NASH with hypertriglyceridemia treated with CILO and FIR, fenofibrate was safe and effectively mitigated increases in triglycerides associated with acetyl-CoA carboxylase inhibition.gov, Number: NCT02781584.
Author Correction: Radiation-activated secretory proteins of Scgb1a1+ club cells increase the efficacy of immune checkpoint blockade in lung cancer
Authors: Yi Ban, Geoffrey J. Markowitz, Yue Zou, Divya Ramchandani, Jeffrey Kraynak, Jianting Sheng, Sharrell B. Lee, Stephen T. C. Wong, Nasser K. Altorki, Dingcheng Gao, Vivek Mittal
Journal: Nature Cancer (2022)
An Incidental Uptake of 18F-Choline in Paraganglioma
Authors: Angelo Castello, Giulia Zuccotti, Elena Bonatto, Luigia Florimonte, Massimo Castellani
Journal: Clinical Nuclear Medicine (2021)

Abstract We present a case of carotid glomus paraganglioma incidentally detected using 18 F-choline PET/CT in a 63-year-old man with prostate cancer. 18 F-choline PET/CT scan demonstrated a small area of 18 F-choline uptake (SUV max , 2.3) in the right parapharyngeal space of the neck, later diagnosed as paraganglioma with low proliferation index. 18 F-choline PET/CT may represent a valid alternative for studying paraganglioma when either 18 F-DOPA or 68 Ga-SSA are not available.
Carotid stent-supported angioplasty with distal neuro-protection using the GuardwireTM: 30-day results from the carotid angioplasty free of emboli (CAFt-USA) trial Gary S. Roubin, Roxana Mehran, Edward Diethrich, Lowell F. Satler, Patrick Whitlow, Takao Ohki, Lee Guterman, Subbarao Myla, Hassan Faraj, Gishel New, Sriram Iyer, Martin B. Leon. Lenox Hill Heart and Vascular Institute, New York, NY
Journal: Journal of the American College of Cardiology (2001)
Comprehensive analysis of death and nonfatal myocardial infarction during the first twelve months following acute nonq-wave myocardial infarction: Comparison of invasive versus conservative strategies in the VA non Q-wave infarction strategies in-hospital (VANQWISH) trial Arun K. Kolli, Michael J. Wade, Robert A. O'Rourke, Alvin S. Blaustein, William E. Boden. Veterans Affairs Medical Center, Syracuse, NY, Hartford Hospital, Hartford, CT
Journal: Journal of the American College of Cardiology (2001)
Symposium on Interferons and Tumor Necrosis Factors: Advances in Clinical Research
Journal: JNCI Journal of the National Cancer Institute (1987)

Symposium on Interferons and Tumor Necrosis Factors: Advances in Clinical Research JNCI: Journal of the National Cancer Institute, Volume 79, Issue 5, November 1987, Page 1173, https://doi.org/10.1093/jnci/79.5.1173-b Published: 01 November 1987
In this issue
Authors: Peter Kirkpatrick, Alexandra Flemming, Charlotte Harrison, Sarah Crunkhorn, Monica Flight, Asher Mullard, Man Tse, Mariam Faruqi, Catriona Rodwell, Lucie Wootton, Isabel Woodman, Lewis Packwood, Susanne Harris, Vicky Summersby, Patrick Morgan, Kirsten Managing, Judith Shadwell, Simon Fenwick, Natalie Smith, Laura Corns, Deborah Anthony, Marketing Managers, Tim Redding, Nazly De, La Rosa, Peter Collins
Journal: Nature Reviews Drug Discovery (2012)
Voluntary Sterilization
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Real-world Evidence of Efficacy and Safety of SGLT2 Inhibitors as Adjunctive Therapy in Adults With Type 1 Diabetes: A European Two-Center Experience
Authors: Ana Palanca, Falco van Nes, Felipe Pardo, F. Javier Ampudia Blasco, Chantal Mathieu
Journal: Diabetes Care (2022)

To evaluate real-world efficacy and safety of sodium-glucose cotransporter 2 inhibitor (SGLT2i) use in combination with insulin in people with type 1 diabetes.We conducted a retrospective cohort European two-center study. Data on demographics, HbA1c, weight, insulin use, renal function, and adverse events were collected for 199 adults with type 1 diabetes who initiated a SGLT2i adjunct to insulin. Subgroup analyses were performed to identify who benefited most and who was more at risk for adverse events.Overall, significant reductions in mean HbA1c (-0.5%), weight (-2.9 kg), and daily insulin (-8.5%) were achieved after 12 months. The greatest reduction in HbA1c was obtained in individuals with baseline HbA1c >8% (-0.7% [64 mmol/mol]). The most weight loss was observed in subjects with BMI >27 kg/m2 (-3.5 kg). Individuals with baseline estimated glomerular filtration rate (eGFR) <90 mL/min/1.73 m2 showed an increase in eGFR (4.5 mL/min/1.73 m2), whereas those with urinary albumin-to-creatinine ratio (UACR) >15 mg/g showed a decrease in UACR (-16.6 mg/g). Fifty-seven individuals (28.6%) reported adverse events: 45 with genital infections (22.6%), 5 ketosis episodes (2.5%), and 7 diabetic ketoacidosis (DKA) (3.5%). No severe hypoglycemia events were reported.Our real-world data on SGLT2i showed promising results in reductions in HbA1c, weight, and insulin requirements in type 1 diabetes. Benefits were more pronounced in individuals with higher baseline HbA1c and BMI. DKA remained a major concern, despite educational measures. Further real-life evidence is still required for evaluation of SGLT2i longer-term effects and their impact on reno-cardiovascular outcomes.
Testicular seminoma and non-seminoma: ESMO-EURACAN Clinical Practice Guideline for diagnosis, treatment and follow-up
Authors: J. Oldenburg, D.M. Berney, C. Bokemeyer, M.A. Climent, G. Daugaard, J.A. Gietema, U. De Giorgi, H.S. Haugnes, R.A. Huddart, R. Leão, A. Sohaib, S. Gillessen, T. Powles
Journal: Annals of Oncology (2022)
Prediction of maintenance of sinus rhythm after electrical cardioversion of chronic nonvalvular atrial firbrillation using pulsed tissue doppler imaging Masami Nishino, Shiro Hoshida, Masayuki Taniike, Yasuyuki Egami, Toshihiro Takeda, Wataru Furumoto, Masayoshi Kawabata, Eiichiro Tsujimura, Junji Kato, Hideo Tanahashi, Jun Tanouchi, Yoshio Yamada. Division of Cardiology, Osaka Rosai Hospital, Sakai, Osaka, Japan
Journal: Journal of the American College of Cardiology (2001)
The Extra Pharmacopeia of Martindale and Westcott.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal