tbuckley/cabot-search huggingface dataset:
Augmentation of humoral and cellular immune responses after third-dose SARS-CoV-2 vaccination and viral neutralization in myeloma patients
Authors: Adolfo Aleman, Oliver Van Oekelen, Bhaskar Upadhyaya, Katherine Beach, Ariel Kogan Zajdman, Hala Alshammary, Kseniya Serebryakova, Sarita Agte, Katerina Kappes, Charles R. Gleason, Komal Srivastava, Steve Almo, Carlos Cordon-Cardo, Florian Krammer, Miriam Merad, Sundar Jagannath, Ania Wajnberg, Viviana Simon, Samir Parekh, D. Andre, A. Azad, R. Banu, M.C. Bermúdez-González, G. Cai, A. Chari, H. Cho, C. Cognigni, K. David, D. Floda, A. Firpo, G. Kleiner, N. Lyttle, W. Mendez, L.C.F. Mulder, R. Mendu, A. Oostenink, A. Rooker, S. Richard, J. Richter, C. Rodriguez, A. Rossi, K. Russo, L. Sanchez, A. Salimbangon, M. Saksena, A. Shin, L. Sominsky, D. Verina
Journal: Cancer Cell (2022)
Economics for people and planet—moving beyond the neoclassical paradigm
Authors: Lina Brand-Correa, Anna Brook, Milena Büchs, Petra Meier, Yannish Naik, Daniel W O’Neill
Journal: The Lancet Planetary Health (2022)

Despite substantial attention within the fields of public and planetary health on developing an economic system that benefits both people's health and the environment, heterodox economic schools of thought have received little attention within these fields. Ecological economics is a school of thought with particular relevance to public and planetary health. In this article, we discuss implications of key ecological economics ideas for public and planetary health, especially those related to critiques of gross domestic product as a measure of progress and economic growth as the dominant goal for economic and policy decision making. We suggest that ecological economics aligns well with public health goals, including concern for equality and redistribution. Ecological economics offers an opportunity to make the transition to an economic system that is designed to promote human and planetary health from the outset, rather than one where social and environmental externalities must be constantly corrected after the fact. Important ideas from ecological economics include the use of a multidimensional framework to evaluate economic and social performance, the prioritisation of wellbeing and environmental goals in decision making, policy design and evaluation that take complex relationships into account, and the role of provisioning systems (the physical and social systems that link resource use and social outcomes). We discuss possible interventions at the national scale that could promote public health and that align with the prioritisation of social and ecological objectives, including universal basic income or services and sovereign money creation. Overall, we lay the foundations for additional integration of ecological economics principles and pluralist economic thinking into public and planetary health scholarship and practice.
SARS-CoV-2 rapid test versus RT-qPCR on noninvasive respiratory self-samples during a city mass testing campaign.
Authors: Julie Gagnaire, Paul Bonjean, Elise Verot, Billal Boulamail, Remi Labetoulle, Sylvie Gonzalo, Delphine Hilliquin, Sylvie Pillet, Patrick Michaud, Amélie Brebion, Florence Morfin, Jérôme Le Goff, Carole Pelissier, Thomas Bourlet, AutoCov study group, Franck Chauvin, Philippe Berthelot, Elisabeth Botelho-Nevers, Bruno Pozzetto
Journal: Journal of Infection (2022)
Prospective genomically guided identification of “early/evolving” and “undersampled” IDH-wildtype glioblastoma leads to improved clinical outcomes
Authors: Yalan Zhang, Calixto-Hope G Lucas, Jacob S Young, Ramin A Morshed, Lucie McCoy, Nancy Ann Oberheim Bush, Jennie W Taylor, Mariza Daras, Nicholas A Butowski, Javier E Villanueva-Meyer, Soonmee Cha, Margaret Wrensch, John K Wiencke, Julieann C Lee, Melike Pekmezci, Joanna J Phillips, Arie Perry, Andrew W Bollen, Manish K Aghi, Philip Theodosopoulos, Edward F Chang, Shawn L Hervey-Jumper, Mitchel S Berger, Jennifer L Clarke, Susan M Chang, Annette M Molinaro, David A Solomon
Journal: Neuro-Oncology (2022)

Abstract Background Genomic profiling studies of diffuse gliomas have led to new improved classification schemes that better predict patient outcomes compared to conventional histomorphology alone. One example is the recognition that patients with IDH-wildtype diffuse astrocytic gliomas demonstrating lower-grade histologic features but genomic and/or epigenomic profile characteristic of glioblastoma typically have poor outcomes similar to patients with histologically diagnosed glioblastoma. Here we sought to determine the clinical impact of prospective genomic profiling for these IDH-wildtype diffuse astrocytic gliomas lacking high-grade histologic features but with molecular profile of glioblastoma. Methods Clinical management and outcomes were analyzed for 38 consecutive adult patients with IDH-wildtype diffuse astrocytic gliomas lacking necrosis or microvascular proliferation on histologic examination that were genomically profiled on a prospective clinical basis revealing criteria for an integrated diagnosis of “diffuse astrocytic glioma, IDH-wildtype, with molecular features of glioblastoma, WHO grade IV” per cIMPACT-NOW criteria. Results We identified that this diagnosis consists of two divergent clinical scenarios based on integration of radiologic, histologic, and genomic features that we term “early/evolving” and “undersampled” glioblastoma, IDH-wildtype. We found that prospective genomically guided identification of early/evolving and undersampled IDH-wildtype glioblastoma resulted in more aggressive patient management and improved clinical outcomes compared to a biologically matched historical control patient cohort receiving standard-of-care therapy based on histomorphologic diagnosis alone. Conclusions These results support routine use of genomic and/or epigenomic profiling to accurately classify glial neoplasms, as these assays not only improve diagnostic classification but critically lead to more appropriate patient management that can improve clinical outcomes.
Effectiveness of a Suicide Prevention Module for Adults in Substance Use Disorder Treatment
Authors: Richard K. Ries, Adam L. Livengood, David Huh, Amanda H. Kerbrat, Martina Fruhbauerova, Brianna Turner, Katherine Anne Comtois
Journal: JAMA Network Open (2022)

Individuals with substance use disorders (SUDs) are at high risk for suicide. The Preventing Addiction Related Suicide (PARS) module is the first suicide prevention module developed in and for community substance use intensive outpatient programs (IOPs).To evaluate the effectiveness of PARS on suicide-related outcomes (ie, knowledge, attitudes, and help-seeking behavior) compared with usual care.This stepped-wedge cluster-randomized clinical trial was conducted from 2017 to 2020, with follow-up assessments conducted after treatment and at 1, 3, and 6 months. Participants included adult outpatients in SUD treatment at community IOPs across western Washington state. Data were analyzed from July 1, 2020, to January 20, 2022.The intervention, PARS, was a 1-session secondary prevention module administered by trained SUD counselors consisting of didactic presentations and group discussions about suicide risk factors, warning signs, and actions to take if suicide risk is observed in self or others. The control group received usual care.Primary outcomes were suicide knowledge, attitudes about suicide, and help-seeking behavior among patients enrolled in an IOP.A total of 906 participants (mean [SD] age, 37.5 [12.0] years; 540 [59.6%] men) were included, with 478 participants receiving usual care and 428 participants receiving PARS. In intent-to-treat analysis from baseline to after treatment, there was a greater improvement in suicide knowledge (d = 0.15; 95% CI, 0.08 to 0.23; P < .001) and a greater reduction in maladaptive attitudes (d = 0.18; 95% CI, 0.14 to 0.25; P < .001) for PARS participants compared with those receiving usual care. Improvements were maintained at follow-up for suicide knowledge (1 month: d = 0.16; 95% CI, 0.07 to 0.22; P < .001; 3 months: d = 0.12; 95% CI, 0.05 to 0.19; P = .001; 6 months: d = 0.13; 95% CI, 0.06 to 0.20; P < .001) and reductions in maladaptive attitudes (1 month: d = 0.20; 95% CI, 0.12 to 0.23; P < .001; 3 months: d = 0.10; 95% CI, 0.05 to 0.16; P < .001; 6 months: d = 0.14; 95% CI, 0.09 to 0.19; P < .001), with 788 participants (87.0%) of the sample responding across time points. From baseline to 6 months, there was a greater improvement in help-seeking in the PARS group vs usual care (d = 0.16; 95% CI, 0.01 to 0.32; P = .04).This stepped-wedge cluster-randomized clinical trial found that PARS was superior to usual care in improving suicide knowledge, maladaptive attitudes, and help-seeking in adults undergoing community addiction treatment. As a 1-session IOP module developed in partnership with community addiction agencies, PARS has the potential for wide impact in the national suicide prevention strategy.ClinicalTrials.gov Identifier: NCT03166709.
Multiloop traction method during endoscopic hemostasis for post-sphincterotomy bleeding of the peridiverticular papilla
Authors: Kosuke Iwano, Haruka Toyonaga, Toshifumi Kin, Tatsuya Ishii, Akio Katanuma
Journal: Endoscopy (2022)

Periampullary diverticulum (PAD) is considered a risk factor for difficult biliary cannulation during endoscopic retrograde cholangiopancreatography (ERCP) because it makes the papilla unidentifiable [1]. Applying a traction force near the papilla has been reported to be effective in PAD biliary interventions [2]. We report a successful case of endoscopic hemostasis in post-sphincterotomy bleeding, using the multiloop traction method (M-loop method), in a patient with PAD [3] ([Video 1]).
Differences in career longevity before and after implementation of the Women’s Tennis Association Tour Age Eligibility Rule and Player Development Programmes: a 25-year study
Authors: Carol L Otis, Brian Hainline, Christopher Harwood, Neeru A Jayanthi, Rick Jensen, Ashley Keber, Emily Kroshus, Thomas Livengood, Kathleen Stroia, Ann Quinn, Sarka Vitkova, Stephanie A Kliethermes
Journal: British Journal of Sports Medicine (2022)

To assess differences in career longevity, as a potential marker of athlete well-being, before and after the 1995 implementation of the Women's Tennis Association (WTA) Age Eligibility Rule (AER) and Player Development Programmes (PDP), which focused on organisational, physical and psychosocial education, skill building and support for adolescent athletes (≤17 years).Career longevity data were collected through 2019 on adolescent players who began professional tournament play between 1970 and 2014 and reached a WTA singles ranking of 1-150 for a minimum of 1 week during their careers. Players were separated into pre-AER/PDP and post-AER/PDP groups, consisting of those who played their first professional events (FPE) before or after 1 January 1995. Measures of career longevity included career duration and premature retirement.Eight-hundred and eleven players were included in this study (51% pre-AER/PDP). The median career duration was 14.2 years for the post-AER/PDP group compared with 12.1 years for the pre-AER/PDP group (p<0.001). Moreover, post-AER/PDP players had higher probabilities of 10-year and 15-year careers compared with pre-AER/PDP players. After adjusting for age at FPE, athletes in the pre-AER/PDP group had an increased risk of shorter career duration (HR 1.55; 95% CI 1.31 to 1.83) and increased odds of premature retirement (OR 5.39; 95% CI 2.28 to 12.75) than athletes in the post-AER/PDP group.Adolescent athletes participating on the WTA after the combined AER/PDP initiative had longer career durations, higher probabilities of 10-year and 15-year careers, and decreased risk of premature retirement compared with those participating prior to AER/PDP. Organisational practices that encompass both education and competition regulation can positively affect career longevity related to improving athlete well-being.
Severely impaired humoral response against SARS-CoV-2 variants of concern following two doses of BNT162b2 vaccine in patients with systemic lupus erythematosus (SLE)
Authors: Arthur Mageau, Valentine Marie Ferré, Tiphaine Goulenok, Charlotte Charpentier, Nicole Delory, Chrystel Francois, Nadhira Houhou-Fidouh, Thomas Papo, Diane Descamps, Karim Sacre
Journal: Annals of the Rheumatic Diseases (2022)
TCTAP A-003 Two-Year Outcomes After PCI in High Bleeding Risk Asian Patients: The Onyx ONE Clear Study
Authors: Hyo-Soo Kim, Jee-Hoon Kang, Abd Kahar Abd Ghapar, Kamaraj Selvaraj, Seung-Ho Hur, Frankie C.C. Tam, Yangsoo Jang, In-Ho Chae, David E. Kandzari, Ajay J. Kirtane, Azeem Latib, Elvin Kedhi, Te-Hsin Lung, So-Jeong You, Stephan Windecker, Gregg W. Stone
Journal: Journal of the American College of Cardiology (2022)
CARMA: what goes around, comes around for the heart
Authors: Rio P Juni, Reinier A Boon
Journal: Cardiovascular Research (2022)

This editorial refers to ‘The conserved long non-coding RNA CARMA regulates cardiomyocyte differentiation’ by M. Kay et al., https://doi.org/10.1093/cvr/cvab281. Unlike skeletal muscles, cardiac muscle does not efficiently regenerate. All adult striated muscle cells are incapable of sufficient proliferation to allow repair. However, skeletal muscle fibres can regenerate through activation of satellite cells and subsequent fusion with pre-existing muscle fibres. There is no such trick in the heart. This is one of the main reasons why patients with heart disease, even after survival of the primary ischaemic event such as an acute myocardial infarction, suffer from heart failure. The damaged myocardium can simply not be repaired. The holy grail is to find ways to induce cardiac repair, either by stem cell-mediated generation of new cardiomyocytes or by stimulating pre-existing cardiomyocytes to undergo proliferation. Both processes take place during embryonic development of the heart, and it is in this process...
Carbon Monoxide Activates PERK-Regulated Autophagy to Induce Immunometabolic Reprogramming and Boost Antitumor T-cell Function
Authors: Paramita Chakraborty, Rasesh Y. Parikh, Seungho Choi, Danh Tran, Monika Gooz, Zachariah T. Hedley, Do-Sung Kim, Dariusz Pytel, Inhong Kang, Satish N. Nadig, Gyda C. Beeson, Lauren Ball, Meenal Mehrotra, Hongjun Wang, Stefano Berto, Viswanathan Palanisamy, Hong Li, Shilpak Chatterjee, Paulo C. Rodriguez, Eduardo N. Maldonado, J. Alan Diehl, Vamsi K. Gangaraju, Shikhar Mehrotra
Journal: Cancer Research (2022)

Mitochondria and endoplasmic reticulum (ER) share structural and functional networks and activate well-orchestrated signaling processes to shape cells' fate and function. While persistent ER stress (ERS) response leads to mitochondrial collapse, moderate ERS promotes mitochondrial function. Strategies to boost antitumor T-cell function by targeting ER-mitochondria cross-talk have not yet been exploited. Here, we used carbon monoxide (CO), a short-lived gaseous molecule, to test whether engaging moderate ERS conditions can improve mitochondrial and antitumor functions in T cells. In melanoma antigen-specific T cells, CO-induced transient activation of ERS sensor protein kinase R-like endoplasmic reticulum kinase (PERK) significantly increased antitumor T-cell function. Furthermore, CO-induced PERK activation temporarily halted protein translation and induced protective autophagy, including mitophagy. The use of LC3-GFP enabled differentiation between the cells that prepare themselves to undergo active autophagy (LC3-GFPpos) and those that fail to enter the process (LC3-GFPneg). LC3-GFPpos T cells showed strong antitumor potential, whereas LC3-GFPneg cells exhibited a T regulatory-like phenotype, harbored dysfunctional mitochondria, and accumulated abnormal metabolite content. These anomalous ratios of metabolites rendered the cells with a hypermethylated state and distinct epigenetic profile, limiting their antitumor activity. Overall, this study shows that ERS-activated autophagy pathways modify the mitochondrial function and epigenetically reprogram T cells toward a superior antitumor phenotype to achieve robust tumor control.Transient activation of ER stress with carbon monoxide drives mitochondrial biogenesis and protective autophagy that elicits superior antitumor T-cell function, revealing an approach to improving adoptive cell efficacy therapy.
Validation and algorithmic audit of a deep learning system for the detection of proximal femoral fractures in patients in the emergency department: a diagnostic accuracy study
Authors: Lauren Oakden-Rayner, William Gale, Thomas A Bonham, Matthew P Lungren, Gustavo Carneiro, Andrew P Bradley, Lyle J Palmer
Journal: The Lancet Digital Health (2022)

Proximal femoral fractures are an important clinical and public health issue associated with substantial morbidity and early mortality. Artificial intelligence might offer improved diagnostic accuracy for these fractures, but typical approaches to testing of artificial intelligence models can underestimate the risks of artificial intelligence-based diagnostic systems.We present a preclinical evaluation of a deep learning model intended to detect proximal femoral fractures in frontal x-ray films in emergency department patients, trained on films from the Royal Adelaide Hospital (Adelaide, SA, Australia). This evaluation included a reader study comparing the performance of the model against five radiologists (three musculoskeletal specialists and two general radiologists) on a dataset of 200 fracture cases and 200 non-fractures (also from the Royal Adelaide Hospital), an external validation study using a dataset obtained from Stanford University Medical Center, CA, USA, and an algorithmic audit to detect any unusual or unexpected model behaviour.In the reader study, the area under the receiver operating characteristic curve (AUC) for the performance of the deep learning model was 0·994 (95% CI 0·988-0·999) compared with an AUC of 0·969 (0·960-0·978) for the five radiologists. This strong model performance was maintained on external validation, with an AUC of 0·980 (0·931-1·000). However, the preclinical evaluation identified barriers to safe deployment, including a substantial shift in the model operating point on external validation and an increased error rate on cases with abnormal bones (eg, Paget's disease).The model outperformed the radiologists tested and maintained performance on external validation, but showed several unexpected limitations during further testing. Thorough preclinical evaluation of artificial intelligence models, including algorithmic auditing, can reveal unexpected and potentially harmful behaviour even in high-performance artificial intelligence systems, which can inform future clinical testing and deployment decisions.None.
Pembrolizumab versus chemotherapy for microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer (KEYNOTE-177): final analysis of a randomised, open-label, phase 3 study
Authors: Luis A Diaz, Kai-Keen Shiu, Tae-Won Kim, Benny Vittrup Jensen, Lars Henrik Jensen, Cornelis Punt, Denis Smith, Rocio Garcia-Carbonero, Manuel Benavides, Peter Gibbs, Christelle de la Fourchardiere, Fernando Rivera, Elena Elez, Dung T Le, Takayuki Yoshino, Wen Yan Zhong, David Fogelman, Patricia Marinello, Thierry Andre
Journal: The Lancet Oncology (2022)
Reproductive factors and the risk of incident dementia: A cohort study of UK Biobank participants
Authors: Jessica Gong, Katie Harris, Sanne A. E. Peters, Mark Woodward
Journal: PLoS Medicine (2022)

Background Women’s reproductive factors have been associated with the risk of dementia; however, these findings remain uncertain. This study aimed to examine the risk of incident all-cause dementia associated with reproductive factors in women and the number of children in both sexes and whether the associations vary by age, socioeconomic status (SES), smoking status, and body mass index (BMI) in the UK Biobank. Methods and findings A total of 273,240 women and 228,957 men without prevalent dementia from the UK Biobank were included in the analyses. Cox proportional hazard regressions estimated hazard ratios (HRs) for reproductive factors with incident all-cause dementia. Multiple adjusted models included age at study entry, SES, ethnicity, smoking status, systolic blood pressure, BMI, history of diabetes mellitus, total cholesterol, antihypertensive drugs, and lipid-lowering drugs. Over a median of 11.8 years follow-up, 1,866 dementia cases were recorded in women and 2,202 in men. Multiple adjusted HRs ((95% confidence intervals (CIs)), p -value) for dementia were 1.20 (1.08, 1.34) ( p = 0.016) for menarche &lt;12 years and 1.19 (1.07, 1.34) ( p = 0.024) for menarche &gt;14 years compared to 13 years; 0.85 (0.74, 0.98) ( p = 0.026) for ever been pregnant; 1.43 (1.26, 1.62) ( p &lt; 0.001) for age at first live birth &lt;21 compared to 25 to 26 years; 0.82 (0.71, 0.94) ( p = 0.006) for each abortion; 1.32 (1.15, 1.51) ( p = 0.008) for natural menopause at &lt;47 compared to 50 years; 1.12 (1.01, 1.25) ( p = 0.039) for hysterectomy; 2.35 (1.06, 5.23) ( p = 0.037) for hysterectomy with previous oophorectomy; and 0.80 (0.72, 0.88) ( p &lt; 0.001) for oral contraceptive pills use. The U-shaped associations between the number of children and the risk of dementia were similar for both sexes: Compared with those with 2 children, for those without children, the multiple adjusted HR ((95% CIs), p -value) was 1.18 (1.04, 1.33) ( p = 0.027) for women and 1.10 (0.98, 1.23) ( p = 0.164) for men, and the women-to-men ratio of HRs was 1.09 (0.92, 1.28) ( p = 0.403); for those with 4 or more children, the HR was 1.14 (0.98, 1.33) ( p = 0.132) for women and 1.26 (1.10, 1.45) ( p = 0.003) for men, and the women-to-men ratio of HRs was 0.93 (0.76, 1.14) ( p = 0.530). There was evidence that hysterectomy (HR, 1.31 (1.09, 1.59), p = 0.013) and oophorectomy (HR, 1.39 (1.08, 1.78), p = 0.002) were associated with a higher risk of dementia among women of relatively lower SES only. Limitations of the study include potential residual confounding and self-reported measures of reproductive factors, as well as the limited representativeness of the UK Biobank population. Conclusions In this study, we observed that some reproductive events related to shorter cumulative endogenous estrogen exposure in women were associated with higher dementia risk, and there was a similar association between the number of children and dementia risk between women and men.
TCTAP C-073 ECMO Assisted CHIP PCI for a Patient With Single Surviving Vessel With Moderate to Severe Calcified Disease With Severe Biventricular Dysfunction
Authors: Nagendra Boopathy Senguttuvan, Harsimran Singh, Santhosh Kumar Periyasamy, Ramesh Sankaran, Vinod Kumar Balakrishnan, S. Sadhanandham, Venkata Balasubramaniyan Jayanty, Preetam Krishnamurthy, Manokar Panchanatham, Thoddi Ramamurthy Muralidharan
Journal: Journal of the American College of Cardiology (2022)
TCTAP C-117 Wire Perforation in Posterior Lateral Artery Treated With Coil During Right Coronary Artery Chronic Total Occlusion Intervention
Authors: Mohd Al-Baqlish Mohd Firdaus, Jayakhanthan Kolanthaivelu, Kumara Gurupparan Ganesan, Shaiful Azmi Yahaya
Journal: Journal of the American College of Cardiology (2022)