tbuckley/cabot-search huggingface dataset:
Guar crispbread in the diabetic diet.
Authors: D J Jenkins, T M Wolever, R Nineham, R Taylor, G L Metz, S Bacon, T D Hockaday
Journal: BMJ (1978)

Nine diabetic patients who were receiving various treatments supplemented their normal home diets (two patients) or metabolic ward diets (seven patients) with guar crispbread for five days. Their mean urinary glucose excretion fell significantly by 38% during the last two days. A significant fall in fasting blood glucose concentration of 1.1 +/- 0.4 mmol/1 (19.8 +/- 7.2 mg/100 ml) was seen only in those who took guar after the control period. Over eight weeks9 treatment insulin dosage was reduced by 21% in five patients, and home testing showed that glycosuria was reduced by 68% in six patients. Guar crispbread is likely to be a useful adjunct to diabetic treatment irrespective of the type of treatment or insulin dosage used.
JAMA 75 YEARS AGO
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Coming Home
Authors: Adam O. Goldstein
Journal: JAMA (1991)

Coming home after vacation is sometimes slightly sad. It's not that your trip was boring or too short. Rather, it's more like a bittersweet dream, when, having suddenly awakened, you are less upset to be awake than sorry you cannot return to your dream. "Please take notice that..." The first day back is always the worst. Restarting routines—unpacking, sorting mail, answering phone messages, washing clothes—these serve a purpose: to center yourself today for tomorrow's work, forgotten while vacationing. The first night back, a few phone calls to family and friends finish the grounding process. Tomorrow, to work, to the hospital. "... the undersigned will bring the above petition on the hearing before this court..." The morning after holds such promise. Invigorated, a refreshed mind can attack daily challenges. Creativity runs high. Many tasks can be solved in a few short hours. The office desk is cleared, and the rooms are ready
Pulmonary Histoplasmosis
Authors: P. G. Arblaster
Journal: Thorax (1950)

Human infection by the fungus Histoplasma capsulatum produces two syndromes which are similar to those following infection by Coccid&oides immitis.The first syndrome to be recognized was a generalized affection of the reticulo- endothelial system, described by Darling (1906, 1908, and 1909) and fully detailed by DeMonbreun (1934).The second syndrome is characterized by pulmonary calcification associated with a positive intradermal response to histoplasmin.It was recognized by Palmer (1945) and more fully described by High, Zwerling, and Furcolow (1947).This is the first report in England of an example of the latter type.The case is of special interest because the 10-year period of observation is longer than in any previously reported case and the presenting symptom is unique.In 1938 Gass, Gauld, Harrison, Stewart, and Williams drew attention to the fact that in Tennessee many people had radiological evidence of pulmonary calcifi- cation but no local response to tuberculin injection.Crimm and Short (1939) postulated that the absence of local response was due to the development of a state of anergy.This theory was disputed by Aronson, Saylor, and Parr (1942), who demonstrated that such patients, following inijection of B.C.G., will in the normal way develop sensitivity to tuberculin.Palmer (1945), investigating similar cases, noted the frequent occurrence of a local reaction to the intradermal injection of histoplasmin, which is a filtrate of a culture in the mycelial phase of Histoplasma ccapsulatum.In the Mississippi valley area High and others (1947) found that 62 out of 15,980 children whose ages ranged from 1 to 18 years old had pulmonary calcification.Of these 93.5% were positive reactors to histoplasmin alone, and a further 3.3% positive reactors to histoplasmin and tuberculin.In the same year Furcolow, Mantz, and Lewis obtained similar results from an investigation of 16,000 children in Kansas City.From this and other similar evidence it has been concluded that in certain geographical areas a significant correlation exists between the presence of intra- thoracic calcification and skin sensitivity to histoplasmin.The demonstration of pulmonary calcification associated with both skin sensitivity to histoplasmin and insensitivity to tuberculin does not in itself justify the conclusion that the pulmonary lesions are due to histoplasmosis.However, Furcolow (1949) has considerably clarified this problem by the isolation of Histoplasma capsulatum from two such cases.
Testicular pain
Authors: G. G Kooiman, P. S Sidhu
Journal: BMJ (2009)

A 17 year old man presented to the accident and emergency department with a seven hour history of sudden onset of left testicular pain and nausea. He did not have dysuria, urethral discharge, urinary frequency, rigors, or a history of scrotal trauma. He was not sexually active. On examination, his left testis was swollen and tender, and he had swelling and erythema of the scrotum. The contents of the right scrotum were normal. He was afebrile and urinalysis was normal. The patient underwent an ultrasound examination (fig 1⇓). Fig 1 A “spectacle” view of both testes with colour Doppler ultrasound ### Short answers
Safety and efficacy of sofosbuvir–velpatasvir–voxilaprevir for re-treatment of chronic hepatitis C virus infection in patients with previous direct-acting antiviral treatment failure in Rwanda (SHARED-3): a single-arm trial
Authors: Neil Gupta, Linda Manirambona, Fabienne Shumbusho, Jules Kabihizi, Anthere Murangwa, Janvier Serumondo, Jean Damascene Makuza, Sabin Nsanzimana, Claude Mambo Muvunyi, Constance Mukabatsinda, Emmanuel Musabeyezu, Gregory Camus, Philip M Grant, Fredrick Kateera
Journal: The Lancet. Gastroenterology & hepatology (2022)
THE BEHAVIOR OF THREE DIFFERENT KINDS OF ANTIBODIES IN TUBERCULOSIS: ANTIPROTEIN, ANTIPOLYSACCHARIDE, AND ANTIPHOSPHATIDE
Authors: Yoshio Takahashi, Tadazumi Onodera, Ken-Ichi Yamamoto
Journal: The Journal of Experimental Medicine (1961)

The mode and the level of production of the three different kinds of antibodies, antipolysaccharide, antiprotein, and antiphosphatide, were found to differ considerably with the mode of infection and the virulence of tubercle bacilli. Evidence is given that production of the antipolysaccharide and antiprotein is stimulated without regard to the mode of infection and the virulence of bacilli, while the antiphosphatide is produced chiefly under conditions where in vivo bacilli might have undergone destruction. Of the three antibodies, the level of antiphosphatide was shown to reflect most faithfully the progression of experimental tuberculous infection. The amounts of the three circulating antibodies were found to have no direct relationship to the degree of tuberculin skin hypersensitivity.
Management of Systemic Therapies and Hepatic Arterial Infusion Chemotherapy in Patients with Advanced Hepatocellular Carcinoma Based on Sarcopenia Assessment
Authors: Takahiro Yamasaki, Issei Saeki, Yurika Yamauchi, Toshihiko Matsumoto, Yutaka Suehiro, Tomokazu Kawaoka, Shinsuke Uchikawa, Akira Hiramatsu, Hiroshi Aikata, Kazufumi Kobayashi, Takayuki Kondo, Sadahisa Ogasawara, Tetsuhiro Chiba, Taro Takami, Kazuaki Chayama, Naoya Kato, Isao Sakaida
Journal: Liver Cancer (2022)

Sarcopenia, defined as the loss of skeletal muscle mass (MM), physical performance, and strength, has been associated with poor clinical outcomes in hepatocellular carcinoma (HCC) patients treated with several therapies. As systemic therapies, including molecular targeted agents, have a strong impact on sarcopenia, we aimed to review the impact of sarcopenia in patients receiving systemic therapies, especially sorafenib and hepatic arterial infusion chemotherapy (HAIC).
Globin vector regulatory elements are active in early hematopoietic progenitor cells
Authors: Annalisa Cabriolu, Ashlesha Odak, Lee Zamparo, Han Yuan, Christina S. Leslie, Michel Sadelain
Journal: Molecular Therapy (2022)

The globin genes are archetypal tissue-specific genes that are silent in most tissues but for late-stage erythroblasts upon terminal erythroid differentiation. The transcriptional activation of the β-globin gene is under the control of proximal and distal regulatory elements located on chromosome 11p15.4, including the β-globin locus control region (LCR). The incorporation of selected LCR elements in lentiviral vectors encoding β and β-like globin genes has enabled successful genetic treatment of the β-thalassemias and sickle cell disease. However, recent occurrences of benign clonal expansions in thalassemic patients and myelodysplastic syndrome in patients with sickle cell disease call attention to the non-erythroid functions of these powerful vectors. Here we demonstrate that lentivirally encoded LCR elements, in particular HS1 and HS2, can be activated in early hematopoietic cells including hematopoietic stem cells and myeloid progenitors. This activity is position-dependent and results in the transcriptional activation of a nearby reporter gene in these progenitor cell populations. We further show that flanking a globin vector with an insulator can effectively restrain this non-erythroid activity without impairing therapeutic globin expression. Globin lentiviral vectors harboring powerful LCR HS elements may thus expose to the risk of trans-activating cancer-related genes, which can be mitigated by a suitable insulator.
Colostrum deficiency.
Authors: H Barrie
Journal: BMJ (1979)

had no hyperacidic peptic ulceration.As regards the second patient, simply oversewing perforations leads to further surgery in 20% of cases in five years.This is extremely rarely required within two months.2The occurrence and timing of recurrence of ulceration in both cases strongly suggests that cimetidine treatment or its withdrawal was implicated.When H2-blockade of acid-secreting cells is withdrawn, it is more likely to lead to excessive sensitivity to normal stimuli than to hyperplasia.
Metabolism and Practical Medicine.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mental problems in rheumatoid arthritis.
Journal: BMJ (1969)

BRDI7UJHOHAL 319 ably owing to reinfection of persons with group A.28 Like- *wise, serological evidence shows that young persons of group o are more often infected with adenoviruses type 3 and 7 than those of group A, but in older people the difference disappears.30Hence repeated exposure of a population obscures genetically determined variations in susceptibility.In studies of volunteers exposed to influenza virus a significantly higher percentage of persons with blood group 0 than those with blood group A became infected.3'Thus there is substantial evidence that susceptibility to infection is under genetic control and that this has many -different aspects.They include destruction of invading Irganisms by leucocytes, acquired immune responses, and other constitutional factors, most of which are not yet -analysed.This is relevant not only to resistance against infection but also the maintenance of genetic diversity in populations.
Delayed, traumatic dislocation of the cervical spine
Authors: L. A. Kessler
Journal: JAMA (1973)

Of the last 39 patients admitted for cervical fracture-dislocations, five had diagnosis delayed from two days to six months, because dislocation was not apparent in the initial x-ray films. Patients with mechanical, cord, or root injuries require special views plus a high index of suspicion and careful follow-up. Head injuries may present inescapable diagnostic and treatment traps.
Vericiguat in patients with coronary artery disease and heart failure with reduced ejection fraction
Authors: Clara Saldarriaga, Dan Atar, Amanda Stebbins, Basil S. Lewis, Imran Zainal Abidin, Robert O. Blaustein, Javed Butler, Justin A. Ezekowitz, Adrian F. Hernandez, Carolyn S.P. Lam, Christopher M. O'Connor, Burkert Pieske, Piotr Ponikowski, Lothar Roessig, Adriaan A. Voors, Kevin J. Anstrom, Paul W. Armstrong
Journal: European Journal of Heart Failure (2022)
Relapsing fever
Authors: M. D. Malison
Journal: JAMA (1979)

RELAPSING fever is an uncommonly diagnosed disease in this country (12 cases reported in 1977).<sup>1</sup>The few cases reported each year mainly occur in the western United States, and only recently has a case been documented that originated east of the Mississippi.<sup>2</sup> Two forms of relapsing fever are recognized, louse-borne (epidemic) and tick-borne (endemic). Both are caused by spirochetes of the genus<i>Borrelia</i>and have similar symptoms. The louse-borne variety requires a human reservoir and is common in many other parts of the world. The only case of louse-borne relapsing fever reported in this century in the United States was in a recent Ethiopian immigrant,<sup>3</sup>but tick-borne relapsing fever has many endemic foci in North America, largely because of the prevalence of animal reservoirs. The following two cases appeared in a two-month period at the same hospital. Both fortuitously were diagnosed by the laboratory technicians, who noticed
On Alcoholic Narcotism
Authors: W. F. Wade
Journal: BMJ (1867)

Pbysloiti fo -the Genen6tf lbspitaI, Biitiymgham: 'f I Am unabilo to dAiit that' the present 9sta6t ot our knowledge alows of any satisfactory theortical explanatibi of the distinct af Iticiputibte ;odg effects produced by ilcohpl in 'ceriafin ease se disease.The mlatke-aand speiey'aimelorat'ion' '"'rtai symptoms is for me a sufi'lent proof tS0t it does good.But I aim 't theifoiie It.oilcy 'omp.e11ed,nor am I propared to mdmnt the truth of anV"theory hitherto propouzid64 wh prrestoa to explain the facts obtervd.These fats romain'to m`y mind un- collocted t Aanxy the6ry, an are o6 a pr"ely' eripT cal character.Sonti'h so ahat ine ee xense rendert i/I :more 'diflldent " pr' 'ou..ing." that p ny give ca4:alcohol*114be beneAl/i , p$r if benefcial, 'in':'t 4natitj it' ill h.'ve to 4 mnist¢d:";.I>raeflha1ly.,thli a less uifortu'iit' or peTplexing 'conieksion tha's, wo*u]4 t aitst s8fht dappea.'Fx!' hold' that-in" aquoAi ne
Ohio State Sanitary Association.
Journal: JAMA (1885)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N6-carboxymethyllysine
Authors: Omar Mossad, Bérénice Batut, Bahtiyar Yilmaz, Nikolaos Dokalis, Charlotte Mezö, Elisa Nent, Lara Susann Nabavi, Melanie Mayer, Feres José Mocayar Maron, Joerg M. Buescher, Mercedes Gomez de Agüero, Antal Szalay, Tim Lämmermann, Andrew J. Macpherson, Stephanie C. Ganal-Vonarburg, Rolf Backofen, Daniel Erny, Marco Prinz, Thomas Blank
Journal: Nature Neuroscience (2022)
Extraperitoneal Fibrosis
Authors: S. Power
Journal: BMJ (1961)

MEDICAL MEMORANDA uBRmJfeature, and frequently the mesenteric and para-aortic nodes were the only ones involved.It has been suggested by Cooke (1958) that there is no evidence that mesenteric lymphoma can be associated with steatorrhoea unless there is involvement of the bowel wall.There was no macroscopic evidence of this in our case, and the small peripheral mesenteric lymph nodes showed fibrosis only.In the case recorded by Friedlander and Gorvy (1955) there was only one small tumour in the ileum, with marked involvement of the mesenteric, retroperitoneal, and parapancreatic nodes.It would therefore appear, as suggested by Comfort (1958), that steatorrhoea may be due to regional lymphatic obstruction.It is apparent that six of the 17 cases recorded by Sleisenger et al. (1953) responded to a low-fat diet for periods up to 20 months.A gluten-free diet may take several months to produce a remission in idiopathic steatorrhoea, and, even if other patients with lympho- matous steatorrhoea might respond to this diet, it is unlikely that they will survive long enough to do so.A gluten-free diet has not yet been shown to be effective in regional enteritis, or Crohn's disease, where there is extensive involvement of the wall of the small intestine, and if, as Cooke (1958) suggests, lymphomatous steatorrhoea is due to involvement of the bowel wall and not lymphatic blockade, a response to this diet, as in our case, might occur.
Leads from the MMWR
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
High-carbohydrate diets and insulin-dependent diabetics.
Authors: J I Mann
Journal: BMJ (1979)

fetal serum AFP that enters the amniotic fluid in the presence of a normal conceptus.Our results and those of Ruoslahti and colleagues emphasise that the AFP con A- binding assay on amniotic fluid has particular value in detecting the presence of communi- cating fetal abnormalities during the period when amniocenteses are usually performed, between the 14th and 18th weeks, in cases where the elevations of amniotic fluid AFP are equivocal or when gestational aging is uncertain.
Medical Journal of Australia, Sydney
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
68Ga-FAPI-04 Versus 18F-FDG PET/CT in a Case of Peutz-Jeghers Syndrome
Authors: Aisheng Dong, Zeyu Zhang, Lu Zhang, Chao Cheng, Changjing Zuo
Journal: Clinical Nuclear Medicine (2022)

Peutz-Jeghers syndrome is a rare inherited hamartomatous polyposis syndrome. We describe 68 Ga-FAPI-04 and 18 F-FDG PET/CT findings in a case of Peutz-Jeghers syndrome with primary duodenal clear cell sarcoma, peritoneal metastases, and multiple intestinal polyps varying in size. The duodenal tumor and its metastases showed increased FDG and FAPI uptake. The peritoneal metastases were delineated more clearly on FAPI PET/CT compared with FDG PET/CT. More interestingly, the intestinal polyps showed increased FDG uptake and no FAPI uptake.