tbuckley/cabot-search huggingface dataset:
Left main coronary artery stenosis: angiographic determination.
Authors: ACameron, H GKemp, L DFisher, AGosselin, M PJudkins, J WKennedy, JLesperance, J GMudd, T JRyan, J FSilverman, FTristani, R EVlietstra, L FWexler
Journal: Circulation (1983)

Reliability of angiographic assessment of the left main coronary artery segment was evaluated by review of 106 coronary cineangiograms from the Coronary Artery Surgery Study. The films were interpreted by three groups of angiographers: those at a clinical site, those at a quality control site, and those on a study census panel. Among the readings of these three groups, there was 41% to 59% agreement on the severity of the lesion, with 80% agreement on whether the lesion was greater or less than 50%. The severity of lesion, its location, or presence of ectasia or calcium did not affect the discrepancy rate, whereas segments that were unusually short, diffusely diseased, or obscured by overlapping vessels were especially difficult to interpret.
Ergonometry in Endoscopic Procedures: Prevention of Musculoskeletal Injuries During Endoscopic Procedures by Using Belt-Like Manouvring Device with Joystick Capabilities
Authors: T Duric
Journal: Endoscopy (2021)

Aims Gastrointestinal endoscopy forms a significant proportion of clinicians’ workloads. However, little attention is given to the ergonomic aspects of endoscopy. Experimental studies showed that forces and loads placed on endoscopists’ bodies during procedures place them at risk of occupational injury. The main goal of the study was to show the difference in muscle work and overload during endoscopic procedures by applying belt-manouvering device (Endojoystick) with joystick abilities. It is a novelty in the area of endoscopic ergonometry with the intent of risk reduction and prevention of musculoskeletal injuries related to endoscopy.
Endothelin-1 induces hypertrophy with enhanced expression of muscle-specific genes in cultured neonatal rat cardiomyocytes.
Authors: HIto, YHirata, MHiroe, MTsujino, SAdachi, TTakamoto, MNitta, KTaniguchi, FMarumo
Journal: Circulation Research (1991)

To determine whether endothelin-1 (ET-1) induces hypertrophy of cardiomyocytes, the effects of ET-1 on the expression of muscle-specific genes and a proto-oncogene, c-fos, in cultured neonatal rat cardiomyocytes were examined by Northern blot analysis. ET-1 (10(-7) M) induced about twofold to fourfold increases in the gene expression of myosin light chain 2, alpha-actin, and troponin I after 6 hours, which continued up to 24 hours. The ET-1-induced increases in mRNA levels for these muscle-specific genes were dose dependent (10(-9) to 10(-7) M). Run-on transcriptional assay showed that the changes in mRNA level for three muscle-specific genes were regulated, at least in part, at the transcriptional level. 12-O-Tetradecanoylphorbol 13-acetate (TPA), a potent protein kinase C activator, and the Ca2+ ionophore ionomycin also increased mRNA levels of three muscle-specific genes. ET-1, TPA, and ionomycin similarly induced the expression of c-fos after 30 minutes, which returned to an undetectable level after 6...
Normal-Pressure Hydrocephalus
Authors: H. S. Panitch
Journal: JAMA (1970)

<h3>To the Editor.—</h3> The syndrome of normal-pressure hydrocephalus has assumed much importance recently as a treatable cause of dementia and deserves to be widely recognized. The report of James et al (<b>213</b>:1615, 1970) is disturbing, however, because of its lack of documentation and apparent neglect of recent developments in this admittedly complex field. The authors state that Since normal-pressure hydrocephalus is a treatable form of dementia, accurate diagnosis based on clinical manifestations, findings from lumbar puncture, pneumoencephalography, and cisternography is mandatory. Yet they fail to provide either clinical, lumbar puncture, or pneumoencephalographic data on their eight patients, with abnormal iodinated I 131 serum albumin (RISA) cisternograms. On what criteria was the diagnosis based in these patients, and was their dementia, in fact, surgically correctible? Any diagnostic test for occult or normal-pressure hydrocephalus is of clinical value only insofar as it correlates with reversibility of signs and symptoms. Unfortunately, data of
Lipoprotein lipids in older people. Results from the Cardiovascular Health Study. The CHS Collaborative Research Group.
Authors: W HEttinger, P WWahl, L HKuller, T LBush, R PTracy, T AManolio, N OBorhani, N DWong, D HO'Leary
Journal: Circulation (1992)

BACKGROUNDCardiovascular disease is the leading cause of death and disability in older people. There is little information about the distributions of risk factors in older populations. This article describes the distribution and correlates of lipoprotein lipids in people greater than or equal to 65 years old.METHODS AND RESULTSLipoprotein lipid concentrations were measured in 2,106 men (M) and 2,732 women (F) who were participants in the Cardiovascular Health Study, a population-based epidemiological study. Distributions of lipids by age and sex and bivariate and multivariate relations among lipids and other variables were determined in cross-sectional analyses. Mean concentrations of lipids were cholesterol: M, 5.20 +/- 0.93 mmol/l (201 +/- 36 mg/dl) and F, 5.81 +/- 0.98 mmol/l (225 +/- 38 mg/dl); triglyceride (TG): M, 1.58 +/- 0.85 mmol/l (140 +/- 75 mg/dl) and F, 1.57 +/- 0.78 mmol/l (139 +/- 69 mg/dl); high density lipoprotein cholesterol (HDL-C): M, 1.23 +/- 0.33 mmol/l (48 +/- 16 mg/dl), and F, 1.53...
Endoscopic Diagnosis Of Histology Type Of Colon Polyp By Using Aceto Acid Chromoendoscopy
Authors: N Ageykina
Journal: Endoscopy (2021)

Methods During colonoscopy, 1.5 %-acetic acid, 5ml, was sprayed onto the identified polyps. Polyps and surrounding mucosa were observed endoscopically for 2 minutes. Then polyps were removed and sent for pathology
Biomimetic Peptides: An Engineered Biomimetic Peptide Regulates Cell Behavior by Synergistic Integrin and Growth Factor Signaling (Adv. Healthcare Mater. 7/2021)
Authors: Lluís Oliver‐Cervelló, Helena Martin‐Gómez, Leslie Reyes, Fatima Noureddine, Elisabetta Ada Cavalcanti‐Adam, Maria‐Pau Ginebra, Carlos Mas‐Moruno
Journal: Advanced Healthcare Materials (2021)

Stimulating integrin and growth factor signaling is a major goal to regulate cell-material interactions. This cover shows a biomimetic peptide containing the RGD cell adhesive motif and the osteogenic DWIVA sequence anchored to a glass model substrate. This work can be found in article number 2001757 by Carlos Mas-Moruno and co-workers. Such functionalized surface fine-tuned the behavior of C2C12 cells in a synergistic manner.
Intracoronary angiotensin-converting enzyme inhibition improves diastolic function in patients with hypertensive left ventricular hypertrophy.
Authors: H LHaber, E RPowers, L WGimple, C CWu, KSubbiah, W HJohnson, M DFeldman
Journal: Circulation (1994)

BACKGROUNDThere is increasing recognition of myocardial angiotensin-converting enzyme, which is induced with the development of left ventricular hypertrophy (LVH). The potential physiological significance of subsequent increased angiotensin I to II conversion in the presence of LVH is unclear but has been postulated to cause abnormal Ca2+ handling and secondary diastolic dysfunction. Accordingly, we hypothesized that acute angiotensin-converting enzyme inhibition would result in decreased production of angiotensin II and improved active (Ca(2+)-dependent) relaxation in patients with hypertensive LVH.METHODS AND RESULTSIntracoronary (IC) enalaprilat was administered to 25 patients with and without LVH secondary to essential hypertension. Indexes of diastolic and systolic LV function were determined from pressure (micromanometer)-volume (conductance) analysis at steady state and with occlusion of the inferior vena cava. Patients were divided into those receiving high- (5.0 mg, n = 15) and low-dose (1.5 mg, ...
The relationship between the strength of the human heart beat and the interval between beats.
Authors: JPidgeon, G AMiller, M INoble, DPapadoyannis, W ASeed
Journal: Circulation (1982)

In 15 patients undergoing cardiac catheterization and pacing tests, the left ventricular (LV) pressure and its maximum rate of rise (LV dP/dt max) were measured with catheter-tip manometers. Atrial or ventricular pacing at a single steady frequency (the priming frequency) was followed by a test pulse at a varying interval (test pulse interval). In 14 subjects in whom it was examined, the contractile response after the test pulse increased with test pulse interval to reach a maximum plateau value--the optimum contractile response (OCR). In five cases, further prolongation of the test pulse interval decreased the contractile response. The optimum test pulse interval occurred at 800-900 msec. An increase in the priming frequency before the introduction of the test pulse caused a progressive increase in OCR, in contrast to the minor effects on LV dP/dt max of the control beats. Similar results were recorded in four other patients in whom contractile response was assessed from the rate of rise of right ventric...
Cellular mechanisms of normal growth in the mammalian heart. II. A quantitative and qualitative comparison between the right and left ventricular myocytes in the dog from birth to five months of age.
Authors: M JLegato
Journal: Circulation Research (1979)

This paper describes and contrasts the changes in myocytes taken from the right and left ventricules of dog heart over the first 5 months of life. The development of the two populations of cells differs in important respects: sarcomeric volume, the proportion of the myocyte occupied by the contractile apparatus, and the volume and surface area of the transverse tubular system all were greater on the average in the left than in the right ventricle (P less than 0.001). Other intracellular structures also changed significantly as development progressed, but did so in both chambers; the surface area and surface-to-volume (s/v) ratio of both right and left ventricular myocytes increased with age (P less than 0.001) as did mitochondrial and mitochondrial-myocyte volume (P less than 0.001). The surface area (P less than 0.01) and the s/v ratio of the mitochondria (P less than 0.001) also increased with development. Nuclear and nuclear myocyte volume grew smaller with age in both chambers (P less than 0.002), as ...
Irrigating Acetic Acid Solution During Colonoscopy for the Detection Of Sessile Serrated Neoplasia: A Randomized Controlled Trial
Authors: G Tribonias, A Theodoropoulou, K Stylianou, I Giotis, A Mpitouli, D Moschovis, Y Komeda, ME Manola, G Paspatis, M Tzouvala
Journal: Endoscopy (2021)

Aims Misdiagnosed sessile serrated lesions (SSLs) are important precursors for interval colorectal cancers. We investigated the usage of acetic acid (AA) solution for improving the detection of SSLs in the right colon in a randomized controlled trial.
Lack of reflex increase in myocardial sympathetic tone after captopril: potential antianginal effect.
Authors: PDaly, BMettauer, J LRouleau, DCousineau, J HBurgess
Journal: Circulation (1985)

Many vasodilators have been tried as antianginal agents, but the reflex increase in sympathetic tone produced by these drugs necessitate their use with caution in patients with angina. In the first part of this study, captopril was given to 14 patients with angina and systolic arterial pressures of greater than 120 mm Hg. Over the short term, captopril decreased arterial blood pressure (from 110 +/- 18 to 98 +/- 18 mm Hg, p less than .01) without increasing heart rate (75 +/- 15 vs 74 +/- 15 beats/min), arterial concentrations of epinephrine (0.38 +/- 0.28 vs 0.34 +/- 0.25 nM) or norepinephrine (2.7 +/- 2.1 vs 2.8 +/- 2.1 nM), or transmyocardial norepinephrine balance (216 +/- 254 vs 146 +/- 170 p mol/min). Captopril decreased average myocardial oxygen consumption (9.7 +/- 4.1 to 8.2 +/- 2.7 ml/min, p less than .01). Given over the long term (mean 5.5 months), captopril decreased the severity of angina from NYHA classification 3.0 +/- 0.8 to 1.6 +/- 0.8. In the second part of this study, captopril was giv...
Radionuclide angiocardiography. Improved diagnosis and quantitation of left-to-right shunts using area ratio techniques in children.
Authors: P OAlderson, R GJost, A WStrauss, SBoonvisut, JMarkham
Journal: Circulation (1975)

A comparison of several reported methods for detection and quantitation of left-to-right shunts by radionuclides was performed in 50 children. Count ratio (C2/C1) techniques were compared with the exponential extrapolation and gamma function area ratio techniques. C2/C1 ratios accurately detected shunts and could reliably separate shunts from normals, but there was a high rate of false positives in children with valvular heart disease. The area ratio methods provided more accurate shunt quantitation and a better separation of patients with valvular heart disease than did the C2/C1 ratio. The gamma function method showed a higher correlation with oximetry than the exponential method, but the difference was not statistically significant. For accurate shunt quantitation and a reliable separation of patients with valvular heart disease from those with shunts, area ratio calculations are preferable to the C2/C1 ratio.
Predictive implications of ventricular premature contractions associated with treadmill stress testing.
Authors: J AUdall, M HEllestad
Journal: Circulation (1977)

Follow-up data on future coronary events was collected on 6,500 patients who had undergone stress testing; 1,327 of these exhibited ventricular premature contractions (VPCs) associated with one or more phases of treadmill stress testing (TSTs). Eighty-three percent of all patients tested had known or suspected cardiovascular disease. The annual incidence of new coronary events (myocardial infarction, angina, cardiac death) during a five year follow-up was 1.7% among 1,067 patients without VPCs or ischemic ST changes, 6.4% in 758 patients with VPCs alone, 9.5% among 609 patients with ischemic ST changes alone and 11.4% in 569 patients with VPCs plus ischemic ST changes. The significance of VPCs associated with the TSTs rests largely upon the clinical status of the persons tested. VPCs observed among patients referred for TSTs for the evaluation of known or suspected cardiovascular disease, with or without ischemic ST abnormalities, represent a definite risk factor for future coronary events.
Reduction in serum cholesterol with pravastatin improves endothelium-dependent coronary vasomotion in patients with hypercholesterolemia.
Authors: KEgashira, YHirooka, HKai, MSugimachi, SSuzuki, TInou, ATakeshita
Journal: Circulation (1994)

BACKGROUNDThis study aimed to determine if cholesterol-lowering therapy improves endothelium-dependent coronary vasomotion in patients with hypercholesterolemia.METHODS AND RESULTSNine patients with hypercholesterolemia were studied before and after cholesterol-lowering therapy with pravastatin (an inhibitor of HMG-CoA reductase) for 6 +/- 3 months, which lowered serum cholesterol from 272 +/- 8 to 187 +/- 16 mg/dL (P < .01). Control patients with serum cholesterol of 218 +/- 23 mg/dL also were studied twice in a similar interval (8 +/- 2 months) with no cholesterol-lowering drugs. Acetylcholine (the endothelium-dependent vasodilator) and papaverine and nitrate (endothelium-independent vasodilators) were infused into the study coronary artery. Changes in the diameter of the epicardial coronary artery and coronary blood flow were assessed by quantitative coronary arteriography and an intracoronary Doppler catheter. In patients with hypercholesterolemia, acetylcholine-induced vasoconstriction of the epicard...
Deep Submucosal Invasion as Independent Risk Factor or Lymph Node Metastasis In T1 Colorectal Cancer: a Systematic Review and Meta-Analysis
Authors: LW Zwager, BAJ Bastiaansen, N Mostafavi, R Hompes, V Barresi, K Ichimasa, H Kawachi, I Machado, T Masaki, W Sheng, S Tanaka, K Togashi, P Fockens, LMG Moons, E Dekker
Journal: Endoscopy (2021)

Aims Accurate risk estimation for lymph node metastasis (LNM) in T1 colorectal cancer (CRC) is critical to optimize further treatment. Multiple studies suggest that deep submucosal invasion (DSI) is not a strong predictor for LNM. Therefore, we conducted a systematic review and meta-analysis to determine whether DSI is an independent risk factor for LNM in T1 CRC.
The status of surgery for cardiac arrhythmias.
Authors: J LCox
Journal: Circulation (1985)

Successful surgical treatment of all forms of supraventricular tachyarrhythmias is dependent on accurate electrophysiologic guidance. Surgery for WPW syndrome is no longer experimental and should be offered to (1) patients with medically refractory reciprocating tachycardia associated with the syndrome, (2) patients with spontaneous atrial fibrillation who are at risk for sudden death, (3) patients with drug intolerance, and (4) young, otherwise healthy patients with symptoms that warrant more than minimal medical therapy. The current results of surgery for WPW syndrome would seem to lessen the likelihood that a major new method of superior nonpharmacologic treatment will emerge in the near future. Surgery for most other types of supraventricular tachyarrhythmias remains experimental and should be applied only under the most controlled circumstances and after satisfying the most rigid criteria for surgical intervention, the main indication being absolute medical refractoriness. The single exception at the...
Antihypertensive treatment and risk of cancer: an individual participant data meta-analysis
Authors: Emma Copland, Dexter Canoy, Milad Nazarzadeh, Zeinab Bidel, Rema Ramakrishnan, Mark Woodward, John Chalmers, Koon K Teo, Carl J Pepine, Barry R Davis, Sverre Kjeldsen, Johan Sundström, Kazem Rahimi, A Adler, L Agodoa, A Algra, F W Asselbergs, N Beckett, E Berge, H Black, F P J Brouwers, M Brown, C J Bulpitt, B Byington, J Chalmers, W C Cushman, J Cutler, B R Davis, R B Devereaux, J Dwyer, R Estacio, R Fagard, K Fox, T Fukui, A K Gupta, R R Holman, Y Imai, M Ishii, S Julius, Y Kanno, S E Kjeldsen, J Kostis, K Kuramoto, J Lanke, E Lewis, J Lewis, M Lievre, L H Lindholm, S Lueders, S MacMahon, G Mancia, M Matsuzaki, M H Mehlum, S Nissen, H Ogawa, T Ogihara, T Ohkubo, C Palmer, A Patel, C J Pepine, M Pfeffer, N R Poulter, H Rakugi, G Reboldi, C Reid, G Remuzzi, P Ruggenenti, T Saruta, J Schrader, R Schrier, P Sever, P Sleight, J A Staessen, H Suzuki, L Thijs, K Ueshima, S Umemoto, W H van Gilst, P Verdecchia, K Wachtell, P Whelton, L Wing, M Woodward, Y Yui, S Yusuf, A Zanchetti, Z Y Zhang, C Anderson, C Baigent, BM Brenner, R Collins, D de Zeeuw, J Lubsen, E Malacco, B Neal, V Perkovic, B Pitt, A Rodgers, P Rothwell, G Salimi-Khorshidi, J Sundström, F Turnbull, G Viberti, J Wang
Journal: The Lancet Oncology (2021)

Some studies have suggested a link between antihypertensive medication and cancer, but the evidence is so far inconclusive. Thus, we aimed to investigate this association in a large individual patient data meta-analysis of randomised clinical trials.
Updated recommendations regarding the management of older patients with breast cancer: a joint paper from the European Society of Breast Cancer Specialists (EUSOMA) and the International Society of Geriatric Oncology (SIOG)
Authors: Laura Biganzoli, Nicolò Matteo Luca Battisti, Hans Wildiers, Amelia McCartney, Giuseppe Colloca, Ian H Kunkler, Maria-João Cardoso, Kwok-Leung Cheung, Nienke Aafke de Glas, Rubina M Trimboli, Beatriz Korc-Grodzicki, Enrique Soto-Perez-de-Celis, Antonio Ponti, Janice Tsang, Lorenza Marotti, Karen Benn, Matti S Aapro, Etienne G C Brain
Journal: The Lancet Oncology (2021)
World Review of Nutrition and Dietetics.
Journal: Annals of Internal Medicine (1972)

State and community programs for mentally deficient (trainable) children are in the processes of rapid development and expansion. With the greatly increased demand for teachers, this book should prove to be most welcome. It should aid both teacher and parents of mentally deficient children not only to better understand what activities and learning experiences will benefit the children, but also  they will. The professional educator often decries the cookbook while the parent and classroom teacher ask for specific suggestions and activities. Teaching the Mentally Retarded Child strikes a happy compromise between these two extremes. Miss Perry uses a developmental approach in suggesting a program for mentally deficient children. Each area starts with a general description incorporating principles and purposes followed by specific examples of activities to be used by teachers and parents. One of the most refreshing things is the justification or why included in each area under discussion. Other pertinent and valuable points of the volume are: (1) the list of principles relating to teaching trainable children. (2) related readings at the conclusion of each chapter, (3) listing of names and functions of agencies that can contribute to a total program, and (4) discussion concerning school-parent problems and relationships. G. ORVILLE JOHNSON
Hyaluronidase does not prevent deterioration of vascular functional integrity during reperfusion after no-flow ischemia in isolated rabbit hearts.
Authors: R GTilton, P ACole, K BLarson, CKilo, J RWilliamson
Journal: Circulation Research (1985)

Effects of hyaluronidase on myocardial water content and distribution, and on coronary vascular hemodynamics and endothelial cell transport function were assessed in isolated rabbit hearts during 3.5 hours of reperfusion after 30 minutes of global, no-flow ischemia. In nonischemic control hearts, perfusion pressure, left ventricular end-diastolic pressure, maximum +dP/dt, and intravascular clearance of radiolabeled albumin remained constant during 5 hours of continuous perfusion, while the mean-transit time and vascular into extravascular space clearance of radiolabeled albumin increased 1.5X and 2.5X baseline, respectively. During reperfusion after 30 minutes of no flow, perfusion pressure increased 53% and interstitial fluid volume increased 2-fold, while left ventricular end-diastolic pressure and maximum +dP/dt returned to control levels. The rate of intravascular clearance of radiolabeled albumin decreased 38%, and the mean-transit time and vascular-into-extravascular space clearance of albumin incre...
Reduction in baroreflex cardiovascular responses due to venous infusion in the rabbit.
Authors: H OStinnett, V SBishop, D FPeterson
Journal: Circulation Research (1976)

We studied reflex bradycardia and depression of mean arterial blood pressure (MAP) during left aortic nerve (LAN) stimulation before and after volume infusion in the anesthetized rabbit. Step increases in mean right atrial pressure (MRAP) to 10 mm Hg did not result in a significant change in heart rate or MAP. After volume loading, responses to LAN stimulation were not as great and the degree of attenuation was propoetional to the level of increased MRAP. A change in responsiveness was observed after elevation of MRAP by only 1 mm Hg, corresponding to less than a 10% increase in average calculated blood volume. after an increase in MRAP of 10 mm Hg, peak responses were attenuated by 44% (heart rate) and 52% (MAP), and the initial slopes (rate of change) were reduced by 46% (heart rate) and 66% (MAP). Comparison of the responses after infusion with blood and dextran solutions indicated that hemodilution was an unlikely explanation for the attenuation of the reflex responses. Total arterial baroreceptor den...