tbuckley/cabot-search huggingface dataset:
Use of yttrium-90 (Y90) glass microspheres (TheraSphere) as neoadjuvant to transplantation/resection in hepatocellular carcinoma: Analyses from the LEGACY study.
Authors: Robert Lewandowski, Guy E. Johnson, Edward Kim, Ahsun Riaz, Vivian Bishay, Siddharth Padia, Riad Salem
Journal: Journal of Clinical Oncology (2021)

300 Background: The objective of the LEGACY study was to assess the Objective Response Rate (ORR) and Duration of Response (DoR) following treatment with Yttrium-90 (Y90) glass microspheres in patients with unresectable solitary hepatocellular carcinoma (HCC). The objective of the analyses presented here are to evaluate ORR, DoR, and Overall Survival (OS) by transplant/resection status and to compare these outcomes with patients who did not go on to transplantation/resection after receiving treatment with Y90. Methods: LEGACY is a single-arm, multicenter, retrospective study of patients with unresectable HCC who received treatment with Y90 glass microspheres (TheraSphere) at one of three sites in the United States. LEGACY included all consecutive eligible patients who received treatment between January 2014 and December 2017 and met the eligibility criteria (Child-Pugh A; ECOG score of 0 or 1; BCLC A or C; and a solitary tumor &gt; 2 and ≤8 cm). Primary efficacy endpoints included ORR and DoR. ORR included patients who achieved either a complete response or partial response based on localized mRECIST; response was assessed via blinded, independent, central review. Secondary endpoints include OS and number and type of subsequent treatments, including transplantation and resection. Results: Among all 162 patients enrolled in LEGACY, ORR was 72.2% (117/162; 95% CI = 64.9%, 78.5%); the majority of patients experienced DoR ≥ 6 months (89/117, 76.1%, 95% CI = 67.6%, 82.9%). Median follow-up time for all 162 patients enrolled in LEGACY was 29.9 months by reverse Kaplan-Meier analysis; 3-year OS was 86.6%. For 45/162 (27.8%) of patients, Y90 treatment served as neoadjuvant therapy; 34 went on to transplantation (21.0%) and 11 (6.8%) went on to resection. For neoadjuvant treatment, ORR was 80.0% (36/45, 95% CI = 66.2, 89.1), DoR ≥ 6 months was 30.6% (11/45, 95% CI = 18.0, 46.9), and 3-year OS was 92.8% (95% CI = 74.2, 98.2). Of these 45 patients, 35 patients achieved complete response (CR), 1 achieved partial response (PR), and 9/45 (20.0%) were deemed not evaluable as they underwent surgery prior to the 6-month mark and did not have imaging assessments post-Day 46. These nine patients were censored, lowering the DoR; however, histopathology revealed that 7/9 (77.8%) achieved complete pathologic necrosis, 1/9 (11.1%) had extensive pathologic necrosis, and 1 (11.1%) had partial pathologic necrosis. For the 117/162 (72.2%) patients who did not go on to surgical treatment, ORR was 91.5% (107/117, 95% CI = 85.0, 95.3), DoR ≥ 6 months was 72.9% (78/117, 95% CI = 63.8, 80.4), and 3-year OS was 83.5% (95% CI = 72.2, 90.5). Conclusions: Treatment of solitary unresectable HCC with Y90 glass microspheres provides strong ORR, DoR, and OS both as neoadjuvant therapy to transplantation/resection and as treatment in non-surgical candidates.
The lines of loco-regional therapies received and the healthcare economic burden of patients newly diagnosed with hepatocellular carcinoma in the United States.
Authors: Brian Seal, Abdulla M. Abdulhalim, Melissa Lingohr-Smith, Jay Lin
Journal: Journal of Clinical Oncology (2021)

286 Background: Hepatocelluar carcinoma (HCC) is one of the fastest growing causes of cancer-related deaths in the US. The objectives of this study were to examine the lines of loco-regional therapies received and the healthcare economic burden of patients newly diagnosed with HCC in the US. Methods: Patients (≥18 years of age) diagnosed with HCC who received ≥1 loco-regional therapy (index date) after diagnosis were identified from the MarketScan Commercial and Medicare Supplemental databases (July 1, 2013-May 31, 2018). Patients were required to have ≥6 months of continuous insurance enrollment before the index date and ≥1 month after (follow-up period). The follow-up period was censored when patients received any systemic therapy. During the follow-up periods, the number of patients who received radiation therapy, ablative therapy, and embolization procedures (transarterial embolization/chemoembolization [TAE] and radioembolization [TARE]) were examined. All-cause and HCC-related healthcare costs (total and patient out-of-pocket [OOP] payments per patient per month [PPPM]) were also measured. Results: Among the 2,101 patients newly diagnosed with HCC who received ≥1 loco-regional therapy, median age was 64 years and 75.0% were male; the mean follow-up duration was 11.5 months. During the follow-up periods, 28.1% (n = 590) received radiation therapy, 27.3% (n = 574) ablative therapy, and 77.3% (n = 1,623) embolization therapy (TAE: 68.7% [n = 1,443]; TARE: 20.7% [n = 434]); 30.9% of patients received multiple loco-regional therapies. During the follow-up periods, total all-cause healthcare costs were a mean of $20,316 (OOP: $378) PPPM, of which 70.7% ($14,359; OOP: $227 PPPM) were HCC-related. The breakdown of healthcare costs is shown in the table. Conclusions: According to the findings of this large-scale real-world analysis of patients newly diagnosed with HCC in the US, a vast majority received at least one embolization procedure. The monthly healthcare economic burden of patients with HCC treated with local-regional therapies is relatively high. [Table: see text]
Spraying Cotton in Bolivar County, Mississippi, the Summer Following My First Year of Medical School
Authors: Doug Hester
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Re: Guohua Zeng, Chao Cai, Xianzhong Duan, et al. Mini Percutaneous Nephrolithotomy Is a Noninferior Modality to Standard Percutaneous Nephrolithotomy for the Management of 20–40 mm Renal Calculi: A Multicenter Randomized Controlled Trial. Eur Urol 2021;79:114–21
Authors: Satoshi Funada, Takashi Yoshioka, Yan Luo
Journal: European Urology (2020)
The International Migration and Recruitment of Nurses
Authors: Lawrence O Gostin
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SAT0062 The role of osteoclast formation in the pathogenesis of osteoporosis in rheumatoid arthritis
Authors: T Hirayama, L Danks, A Sabokbar, NA Athanasou
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> Rheumatoid arthritis (RA) is a systemic inflammatory disorder in which there is destruction of articular cartilage and bone. RA may be complicated by osteoporosis, but the cause of this generalised bone loss is not known. Bone resorption is carried out by osteoclasts which are formed from mononuclear precursors that circulate in the monocyte fraction. <h3>Objectives</h3> Our aims are to determine whether there is an increase in the number of circulating osteoclast precursors in RA patients relative to age/sex matched osteoarthritis (OA) controls. We also examined the sensitivity of these precursors to known factors required for osteoclastogenesis. <h3>Methods</h3> Peripheral blood mononuclear cells (PBMCs) from 10 RA patients and 10 age/sex matched OA controls were cultured on dentine slices and glass coverslips for up to 21 days in the presence of various concentrations of soluble RANKL (sRANKL) and M-CSF, or in the presence of RANKL-expressing UMR106 cells with various concentrations of M-CSF and 1,25(OH)<sub>2</sub> vitamin D3. Cells were cultured with and without dexamethasone (Dex) at 10–8M. <h3>Results</h3> As assessed by expression of the osteoclast markers, TRAP and lacunar resorption, PBMC serial dilution studies showed no difference in the number of circulating osteoclast precursors in RA patients and OA controls. However, osteoclasts formed from PBMCs of RA patients were capable of substantially more resorption than osteoclasts formed in OA patients (p = 0.008). PBMCs from RA patients exhibited increased sensitivity to the osteoclastogenic effect of M-CSF when cultured with sRANKL (p = 0.004) or with UMR106 cells (p = 0.05). When cultured with UMR106 cells, an increase in sensitivity to 1,25(OH)2D3 (p = 0.02) was noted in RA patients compared to OA controls. PBMCs from RA patients also showed increased sensitivity to the effect of sRANKL. PBMCs from both RA (p = 0.001) and OA (p = 0.001) patients cultured in the presence of Dex exhibited significantly more lacunar resorption than cultures to which no Dex was added. <h3>Conclusion</h3> These findings suggest that the increase in generalised bone loss seen in RA results not from an increase in the absolute number of circulating osteoclast precursors but to an increase in the sensitivity of these precursors to local/systemic factors (i.e. M-CSF, RANKL, 1,25(OH)2D3 and corticosteroids) that influence osteoclast formation and bone resorbing activity. <h3>References</h3> Fujikawa Y, Quinn J, Sabikbar A, McGee JO, Athanasou NA. The human mononuclear osteoclast precursor circulates in the monocyte fraction. Endocrinology 1996;139:4058–60 Bertolini DR, Nedwin GE, Bringmann TS, Smith DD, Mundy GR. Stimulation of bone resorption and inhibition of bone formation <i>in vitro</i> by human TNF. Nature 1986;319;516–18
Sex-Stratified Gene Regulatory Networks Reveal Female Key Driver Genes of Atherosclerosis Involved in Smooth Muscle Cell Phenotype Switching
Authors: Robin J.G. Hartman, Katie Owsiany, Lijiang Ma, Simon Koplev, Ke Hao, Lotte Slenders, Mete Civelek, Michal Mokry, Jason C. Kovacic, Gerard Pasterkamp, Gary Owens, Johan L.M. Björkegren, Hester M. den Ruijter
Journal: Circulation (2021)

Although sex differences in coronary artery disease are widely accepted with women developing more stable atherosclerosis than men, the underlying pathobiology of such differences remains largely unknown. In coronary artery disease, recent integrative systems biological studies have inferred gene regulatory networks (GRNs). Within these GRNs, key driver genes have shown great promise but have thus far been unidentified in women.We generated sex-specific GRNs of the atherosclerotic arterial wall in 160 women and age-matched men in the STARNET study (Stockholm-Tartu Atherosclerosis Reverse Network Engineering Task). We integrated the female GRNs with single-cell RNA-sequencing data of the human atherosclerotic plaque and single-cell RNA sequencing of advanced atherosclerotic lesions from wild type and Klf4 knockout atherosclerotic smooth muscle cell (SMC) lineage-tracing mice.By comparing sex-specific GRNs, we observed clear sex differences in network activity within the atherosclerotic tissues. Genes more active in women were associated with mesenchymal cells and endothelial cells, whereas genes more active in men were associated with the immune system. We determined that key drivers of GRNs active in female coronary artery disease were predominantly found in (SMCs by single-cell sequencing of the human atherosclerotic plaques, and higher expressed in female plaque SMCs, as well. To study the functions of these female SMC key drivers in atherosclerosis, we examined single-cell RNA sequencing of advanced atherosclerotic lesions from wild type and Klf4 knockout atherosclerotic SMC lineage-tracing mice. The female key drivers were found to be expressed by phenotypically modulated SMCs and affected by Klf4, suggesting that sex differences in atherosclerosis involve phenotypic switching of plaque SMCs.Our systems approach provides novel insights into molecular mechanisms that underlie sex differences in atherosclerosis. To discover sex-specific therapeutic targets for atherosclerosis, an increased emphasis on sex-stratified approaches in the analysis of multi-omics data sets is warranted.
Sterilization of Semiconductive Nanomaterials: The Case of Water‐Suspended Poly‐3‐Hexylthiophene Nanoparticles
Authors: Filippo Monti, Giovanni Manfredi, Ilaria Elena Palamà, Alessandro Kovtun, Mattia Zangoli, Stefania D'Amone, Luca Ortolani, Gaia Bondelli, Tomasz Szreder, Krzysztof Bobrowski, Mila D'Angelantonio, Guglielmo Lanzani, Francesca Di Maria
Journal: Advanced Healthcare Materials (2021)

Abstract In this work, the feasibility of sterilizing a water suspension of poly‐3‐hexylthiophene nanoparticles (P3HT‐NPs) is investigated using ionizing radiation, either γ ‐rays or high‐energy electrons (e‐beam). It is found that regardless of the irradiation source, the size, polydispersity, aggregation stability, and morphology of the NPs are not affected by the treatment. Furthermore, the impact of ionizing radiation on the physicochemical properties of NPs at different absorbed radiation doses (10–25 kGy) and dose rates (kGy time −1 ) is evaluated through different spectroscopic techniques. The results indicate that delivering a high dose of radiations (25 kGy) at a high dose rate, that is, kGy s −1 , as achieved by e‐beam irradiation, preserves the characteristics of the polymeric NPs. Differently, the same radiation dose but delivered at a lower dose rate, that is, kGy h −1 , as attained by using a γ ‐source, can modify the physicochemical properties of the polymer. Sterility tests indicate that an absorbed dose of 10 kGy, delivered either with γ ‐rays or e‐beam, is already sufficient for effective sterilization of the colloidal suspension and for reducing the endotoxin content. Finally, NPs irradiated at different doses, exhibit the same cytocompatibility and cell internalization characteristics in human neuroblastoma SH‐SY5Y cells of NPs prepared under aseptic conditions.
AB1287-HPR INVESTIGATION OF THE RELATIONSHIP BETWEEN GRIP ENDURANCE, DISABILITY OF UPPER EXTREMITY AND QUALITY OF LIFE IN PATIENTS WITH RHEUMATOID ARTHRITIS
Authors: M. Köprülüoğlu, İ. Naz Gürşan, D. Solmaz, G. Kabadayi, H. Cinakli, S. Akar
Journal: Annals of the Rheumatic Diseases (2020)

Background: Upper extremity functions affect the quality of life at different levels in patients with rheumatoid arthritis (RA). In the current literature; it has been shown that grip endurance is associated with upper limb functions (1). However, there is no study investigating the relationship between grip endurance and quality of life in patients with RA. Objectives: To investigate relationship between grip endurance, disability of upper extremity and quality of life in patients with RA. Methods: In our cross sectional study, 23 RA patients [Mean age; 52.7±12.6, BMI;26.9±5.7 kg/m 2 , Women;20(87.0%)] who were classified according to the ACR 2010 criteria. Demographics and clinical characteristics of patients were recorded (Table 1). Das28 for disease activity score, Static and dynamic grip endurance measurements using Hand Dynamometer (Lafayette Proffessional Hand Dynamometer, USA) for grip endurance, Disability of Arm, Shoulder and Hand Survey (DASH) for disabilities and symptoms of upper extremity and Short Form-36 Health Survey for quality of life were performed. Spearman’s Rank Correlation Coefficient was used for data analysis. Table 1. Demografic and Clinical Characteristics of Patients Variables (n=23 ) Median(IQR 25/75 ) Age (year) 56(41/62) BMI (kg/m2) 27,5(21.4/32.0) Disease Duration(year) 8(5/15) Morning Stiffness (VAS/mm) 38(23/48) Perceived Disability of Hand (VAS,mm) 47(25/67) Clinician Disability of Hand (VAS,mm) 30(20/39) Number Of Tender Hand Joint 2(0/6) Number Of Swollen Hand Joint 0(0/1) CRP(mg l) 3,3(1.8/7.1) ESR(nm/h) 13(6/21) n(% ) Morning Stiffness Duratton 0-15 minutes 8 (34.8) 15-30 minutes 5 (21.7) 30-60 minutes 3 (13.0) Longer than 1 hours 7 (30.4) Das28 Remission 11(47.8) Low Activity 2(8.7) Moderate Activity 7(30.4) High Activity 3(13.0) Data is presented median (interquantile range) or percentile (%). Results: Grip endurance was negatively correlated with DASH and positively correlated with many different quality of life parameters, especially physical function, on both the dominant and non-dominant sides (p &lt;0.05). DASH was correlated negatively with SF-36 physical function, rol limitataion due to physical health, pain subparameters and positively correlated with Das28 score (p&lt;0.05). Conclusion: In our study, it was concluded that grip endurance was related to upper extremity functions and quality of life in patients with RA. This result shows that; assessment of grip endurance can be a guide for clinicians who have designed an upper limb rehabilitation program for patients with RA. References: 1. VERMA, Chhaya, et al. Correlation of functional ability of the hand with upper limb function and quality of life in patients with rheumatoid arthritis. J Assoc Physicians India , 2017, 65: 20-4. Disclosure of Interests: None declared
Come Together: Sports Medicine for Everybody—the 2021 American Medical Society for Sports Medicine issue
Authors: Katherine Rizzone, Cynthia R LaBella
Journal: British Journal of Sports Medicine (2021)

This annual partnership issue from the American Medical Society for Sports Medicine (AMSSM) features the latest high-quality research and scholarship from AMSSM members. We also are excited to share the theme of the upcoming AMSSM annual meeting, ‘Come Together: Sports Medicine for Everybody,’ to be held from 13 to 18 April 2021 in San Diego, California.

In 2019, AMSSM hosted the Youth Early Sports Specialization Summit. We are delighted to present a key product from that meeting, ‘Defining a Research Agenda for Youth Sport Specialization: The AMSSM Youth Early Sport Specialization Summit’ (see page 135) . This summary statement reviews the current literature, identifies key findings, limitations and knowledge gaps, and outlines the priorities for future research on youth sport specialisation. Dr Joseph Baker provides an additional perspective on this topic in his commentary, ‘Is it too early to condemn early sports specialization?’ (see page 179) .

AMSSM also presents an important position …
HP0005 Expectations of ra-patients, rheumatologists and physiotherapists about the outcome of high intensity exercise programs in comparison with conventional exercise programs
Authors: M Munneke, Z De Jong, HK Ronday, CH Van den Ende, TP Vliet Vlieland, JM Hazes
Journal: Annals of the Rheumatic Diseases (2001)

<h3></h3> Results of recent studies indicate that high intensity exercise programs may be beneficial for patients with RA. Beliefs about the outcomes of high intensity exercise will influence the willingness of rheumatologists and physiotherapists (PT's) to refer patients for participation in high intensity exercise programs and the willingness of RA patients themselves to participate in such programs. The aim of this study was to examine the expectations of rheumatologists, PT's and RA-patients with respect to the outcome of high intensity exercise in comparison with conventional exercise. <h3>Methods</h3> A self-developed exercise beliefs questionnaire was administered to 153 rheumatologists, 624 PT's and 807 RA-patients who were eligible for participation in a multicenter, randomised controlled trial on the effect of a long-term intensive exercise programme. The questionnaire comprised two questions about negative outcome expectations (exercise results in joint damage and exercise results in an increase of disease activity) and two questions about positive outcome expectations (exercise is beneficial, exercise results in an increase in physical fitness) for both high intensity exercise and conventional exercise separately. Total scores for outcome expectations were calculated and ranged from very negative (–6) to very positive (6). <h3>Results</h3> The response rates for rheumatologists, PT's and patients were 83%, 70% and 75%. Only the results of PT's treating at least one RA-patient per week (n = 121, 28% of responding PT's) are presented. <h3>Conclusion</h3> Rheumatologists, PT's and RA-patients have more negative expectations about the outcome of high intensity exercise than about the outcome of conventional exercise. This finding may be a potential barrier for referral to or participation in high intensity exercise programs. Factors underlying the relatively negative attitude towards high intensity exercise, such as a lack of information and personal experiences with high intensity exercise, need to be further examined.
Management of hypersensitivity reactions to chemotherapy and biologic agents: A survey of ARADyAL (Asthma, Adverse Drug Reactions and Allergy Network) Spanish allergy services
Authors: Teodorikez‐Wilfox Jimenez‐Rodriguez, María Pilar Berges‐Gimeno, Ruth Barranco, Joan Bartra, María del Carmen Diéguez, Inmaculada Doña, Montserrat Fernández‐Rivas, Maria Del Mar Gandolfo‐Cano, Gabriel Gastaminza‐Lasarte, Eloína González‐Mancebo, Belén de la Hoz Caballer, Leticia Sánchez‐Morillas, María José Torres, Arantza Vega, Rosa Muñoz‐Cano
Journal: Allergy (2021)

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