tbuckley/cabot-search huggingface dataset:
Posters
Authors: Fronc Ŝifrer, Igor Drinovec, G. Thomson, L. Baker, E. Mawby, R. M. Leach, P. J. Jensen, G. Michagin, P. K. Andersen, J. Peláez, M. J. Asensio, M. Jiménez, S. Yus, P. Villa, C. Vaquero, M. Imhoff, J. H. Lehner, D. Löhlein, G. Vignali, A. Guadagnucci, M. Mariotti, A. Baratta, A. Vignali, A. Rutili, G. Tulli, C. Sanft, C. Spies, G. Oschmann, W. Schaffartzik, T. Gondos, M. Arkosy, M. Jović, Z. Popović, B. Radomir, V. Ilić, G. Panić, M. Babić, A. Popović, M. Bojić, E. Pierucci, C. Ghermandi, A. Morigi, R. Morgagni, M. Nastasi, R. Rossi, G. Martinelli, S. Faenza, F. Cuccolini, G. Martinelli, E. Sarti, B. O’Hare, P. Betit, J. E. Thompson, D. L. Wessel, T. J. Kuhn, B. L. Bauer, C. J. Broomhead, S. J. Wright, K. J. Kiff, P. S. Withington, L. Strunin, J. L. G. Amaral, J. -J. Rouby, L. Gallart, M. Munechika, P. Coriat, F. Michard, M. Wysocki, H. Millet, M. A. Wolff, B. Herman, M. Peyerl, O. Gödje, T. Fischlein, U. Pfeiffer, B. Reichart, C. G. Krenn, A. Baker, P. Krafft, E. Narzt, C. K. Spiss, H. Steltzer, H. Theilen, M. Ragaller, D. M. Albrecht, J. Llagunes, J. C. Catala, J. I. Marques, J. J. Pena, D. Barbas, F. Aguar, F. Grau, I. Navarrete-Sánchez, H. Ruiz-Bailén, F. Guerrero-López, H. Colmenero-Ruiz, E. Fernández-Hondéjar, G. Vázquez-Hata, F. J. Lamb, A. Rhodes, D. Duane, R. M. Grounds, E. D. Bennett
Journal: Intensive Care Medicine (1996)
Leads from the MMWR. Primary resistance to antituberculosis drugs--United States
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A NATIONAL DEPARTMENT OF HEALTH.
Journal: JAMA (1906)

The government is designed for the welfare of the people, and in a government like ours, of the whole people, one of the first considerations in the people's welfare is their health; material resources are secondary. Without an able-bodied race, no country can prosper, and it is the favoring health conditions of the temperate zones that have made the races inhabiting them the rulers of the world. With the artificial conditions of civilization, however, the problem of the public health comes more and more to the front, and the old<i>laissez faire</i>methods show their deficiencies. More than one country at the present time is seeking methods and means to check the degenerative tendencies that threaten them, and the question whether our civilization is to last seems largely to depend on the success of these efforts. The paper of Professor Norton, published in this issue ofThe Journal, puts forth
Correction: Allogeneic haematopoietic cell transplantation for myelofibrosis: proposed definitions and management strategies for graft failure, poor graft function and relapse: best practice recommendations of the EBMT Chronic Malignancies Working Party
Authors: Donal P. McLornan, Juan Carlos Hernandez-Boluda, Tomasz Czerw, Nicholas Cross, H. Joachim Deeg, Marcus Ditschkowski, Mufaddal T. Moonim, Nicola Polverelli, Marie Robin, Mahmoud Aljurf, Eibhlin Conneally, Patrick Hayden, Ibrahim Yakoub-Agha
Journal: Leukemia (2021)
Diagnosing Myiasis
Authors: Noel Guillozet
Journal: JAMA (1980)

Misdiagnosis of cutaneous myiasis results in incorrect treatment, anxiety, and excessive scarring. In both temperate and tropical zones, the larvae of a variety of Diptera flies with different reproductive patterns are responsible for myiatic skin conditions and other symptoms. Suspicion of myiasis in the presence of an unhealing insect bite or furuncle can lead to prompt, simple, and effective treatment. (<i>JAMA</i>244:698-699, 1980)
Characterization of eosinophilic esophagitis variants by clinical, histological, and molecular analyses: A cross‐sectional multi‐center study
Authors: Thomas Greuter, Alex Straumann, Yuniel Fernandez‐Marrero, Nina Germic, Aref Hosseini, Shida Yousefi, Dagmar Simon, Margaret H. Collins, Christian Bussmann, Mirna Chehade, Evan S. Dellon, Glenn T. Furuta, Nirmala Gonsalves, Ikuo Hirano, Fouad J. Moawad, Luc Biedermann, Ekaterina Safroneeva, Alain M. Schoepfer, Hans‐Uwe Simon
Journal: Allergy (2022)

Physicians are increasingly confronted with patients presenting with symptoms of esophageal dysfunction resembling eosinophilic esophagitis (EoE), but absence of significant esophageal eosinophilia. The purpose of this study was to characterize and classify this group of EoE variants.Patients from six EoE-centers with symptoms of esophageal dysfunction, but peak eosinophil counts of <60/mm2 (<15/hpf) in esophageal biopsies and absence of gastro-esophageal reflux disease (GERD) were included. Clinical, endoscopic, (immuno)-histological, and molecular features were determined and compared with EoE, GERD, and healthy controls.We included 69 patients with EoE variants. Endoscopic abnormalities were found in 53.6%. We identified three histological subtypes: EoE-like esophagitis (36/69, 52.2%), lymphocytic esophagitis (14/69, 20.3%), and non-specific esophagitis (19/69, 27.5%). Immunohistochemistry revealed-in contrast to EoE-no significant increase in inflammatory cell infiltrates compared with GERD and healthy controls, except for lymphocytes in lymphocytic esophagitis. EoE-typical Th2-response was absent in all EoE variants. However, considerable structural changes were detected based on histology and protein expression. Using next generation mRNA sequencing, we found the three EoE variants to have distinct molecular fingerprints partially sharing pronounced traits of EoE. Hierarchical sample clustering of RNA sequencing data confirmed the presence of an EoE-like (characterized by eotaxin-3 expression), non-specific, and lymphocytic variant cluster (characterized by CD3 cells and TSLP expression).All EoE variants are clinically and histologically active conditions despite the absence of esophageal eosinophilia. EoE variants appear to be part of a disease spectrum, where classical EoE represents the most common and apparent phenotype.
Constraints of pay policies
Authors: R Blaylock, J Brash, L Bromnley, Y-N, Y Chow, J Craig, S De, N Dave, P-M De Bisscop, J Deves, A Dissanayaka, J Doran, R Drahaman, H El-Meshad, S M E-S Deeb, M Erian, R Fahmy, A Fernandes, S Filobbos, J Forbes, F Ford, K Fung, G Giles, A Gottschalk, J Gower, J Griffin, W Hall, G Howe, M Hsu, P Jamieson, S Jayaratne, J Jones, H Kazzaz, F Konetschnik, L Kumar, F Leahey, D Lee, R Leicester, R Mcguiness, H Ma, S Magsi, F Maurice, J Maxted, A Mikhail, A Mitra, J Modha, B Mohd, H El-Molahez, S Moore, M Muayed, D Mukasa, S Muthu, K Parasuraman, G Pellenc, G Penzhorn, V Reddy, N Reddy, J Rees, A Rehan, M Rowntree, R Sabharwal, K Saha, J Sanderson, G Sant, P Savage, T Scotland, W Scott, K Shah, S Sharma, S Shukla, A Silverstone, H Tariq, V Venugopal, M Wahab, R Watts, M White, D B-Wijetunge, C Wong
Journal: BMJ (1976)

Nation's health A falling birthrate, smaller families, and fewer abortions are the main trends seen in the vital statistics analysed by Sir Henry Yellowlees in his CMO's report for 1974, On the State of the Public Health (HMSO price £170).The birth rate for the year of 13/1000 was an unpreceden- ted low level, says the report, adding that "amongrecently married couples there is evidence of a conscious desire to postpone starting a family'and space their children."However, the perinatal and infant mortality rates in Britain were still behind many of our European neighbours: lower perinatal mor- tality was recorded by Bulgaria, Czechoslo- vakia, Denmark, Finland, France,
SOCIETY NEWS.
Journal: JAMA (1893)

<h3>Colorado State Medical Society.</h3> —The State Medical Society held its twenty-third annual session in Denver, June 20, 21 and 22. In attendance, and in the interest manifested, it was the best meeting that has been yet held. The profession of Colorado is earnest, progressive and untiring in the advancement of medical science. The scientific element of the meeting was most marked. The officers for the ensuing year are as follows: President, Edmund J. A. Rogers; first vice-president, A. M. Bucknum; second vice-president, M. Harrison; third vice-president, Kate R. Lobingier; treasurer, W. F. McClelland; corresponding secretary, A. S. Lobingier; recording secretary, E R. Axtell. The election of Dr. Rogers was a most proper recognition of his interest in and work for the society in the past, and as well a fitting rebuke to the method resorted to in the effort to accomplish his defeat. The honors of the society properly belong
Long-Term Complications in Youth-Onset Type 2 Diabetes
Authors: Petter Bjornstad, Kimberly L Drews, Sonia Caprio, Rose Gubitosi-Klug, David M Nathan, Bereket Tesfaldet, Jeanie Tryggestad, Neil H White, Philip Zeitler
Journal: New England Journal of Medicine (2021)

The prevalence of type 2 diabetes in youth is increasing, but little is known regarding the occurrence of related complications as these youths transition to adulthood.
Unlabeled aspirin as an activatable theranostic MRI agent for breast cancer
Authors: Kowsalya Devi Pavuluri, Ethan Yang, Vinay Ayyappan, Kanchan Sonkar, Zheqiong Tan, Caitlin M. Tressler, Shaowei Bo, Adnan Bibic, Kristine Glunde, Michael T McMahon
Journal: Theranostics (2022)

Rationale: Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) is emerging as an alternative to gadolinium-based contrast MRI.We have evaluated the possibility of CEST MRI of orthotopic breast tumor xenografts with unlabeled aspirin's conversion to salicylic acid (SA) through various enzymatic activities, most notably inhibition of cyclooxygenase (COX)-1/-2 enzymes.Methods: We measured the COX-1/-2 expression in four breast cancer cell lines by Western Blot analysis and selected the highest and lowest expressing cell lines.We then performed CEST MRI following aspirin treatment to detect SA levels and ELISA to measure levels of downstream prostaglandin E2 (PGE2).We also injected aspirin into the tail vein of mice growing orthotopic tumor xenografts which expressed high and low COX-1/-2 and acquired SA CEST MR images of these tumor xenografts for up to 70 minutes.Tumors were then harvested to perform Western Blot and ELISA experiments to measure COX-1/-2 expression and PGE2 levels, respectively.Results: Western Blots determined that SUM159 cells contained significantly higher COX-1/-2 expression levels than MDA-MB-231 cells, in line with higher levels of downstream PGE2.SA CEST MRI yielded similar contrast at approximately 3% for both cell lines, independent of COX-1/-2 expression level.PGE2 levels decreased by about 50% following aspirin treatment.Results from our mouse study aligned with cultured cells, the overall SA CEST MRI contrast in both MDA-MB-231 and SUM159 tumor xenograft models was 5~8% at one hour post injection.PGE2 levels were ten times higher in SUM159 than MDA-MB-231 and decreased by 50%.The CEST contrast directly depended on the injected dose, with ~6%, ~3% and ~1.5% contrast observed following injection of 100 µL of 300 mM, 200 mM and 150 mM aspirin, respectively.Conclusions: Our data demonstrate the feasibility of using aspirin as a noninvasive activatable CEST MRI contrast agent for breast tumor detection.
Patient-reported outcome measures are associated with health care utilization in patients with transplant ineligible multiple myeloma: a population-based study
Authors: Hira Mian, Rinku Sutradhar, Gregory R. Pond, Branavan Sivapathasundaram, Jonathan Sussman, Amaris Balitsky, Anita D’Souza, Tanya M. Wildes, Hsien Seow
Journal: Blood Cancer Journal (2022)
Heparin Octasaccharides Inhibit Angiogenesis <i>In vivo</i>
Authors: Jurjees Hasan, Steven D. Shnyder, Andrew R. Clamp, Alan T. McGown, Roy Bicknell, Marco Presta, Michael Bibby, John Double, Steven Craig, David Leeming, Kenneth Stevenson, John T. Gallagher, Gordon C. Jayson
Journal: Clinical Cancer Research (2005)

Abstract Background: In previous experiments, we showed that heparin oligosaccharides inhibit the angiogenic cytokine fibroblast growth factor-2. Here, we present the first in vivo study of size-fractionated heparin oligosaccharides in four models of angiogenesis that are progressively less dependent on fibroblast growth factor-2. Experimental Design: Heparin oligosaccharides were prepared using size-exclusion gel filtration chromatography and characterized through depolymerization and strong anion exchange high-performance liquid chromatography. Size-defined oligosaccharides (20 mg/kg/d) were given to mice bearing s.c. sponges that were injected with fibroblast growth factor-2 (100 ng/d). After 14 days, octasaccharides and decasaccharides reduced the microvessel density to levels below control. In a second experiment, HEC-FGF2 human endometrial cancer cells that overexpress fibroblast growth factor-2 were implanted in a hollow fiber placed s.c. in vivo. Oligosaccharides were given at 20 mg/kg/d for 2 weeks and the data again showed that octasaccharides significantly reduced microvessel density around the fiber (P = 0.03). In a more complex model, where angiogenesis was induced by a broad spectrum of growth factors, including vascular endothelial growth factor, we implanted H460 lung carcinoma cells in hollow fibers and treated the animals with oligosaccharides at 20 mg/kg/d over 3 weeks. Octasaccharides reduced the microvessel density to that of control. Preliminary investigation of 6-O-desulfated heparins showed that these also had antiangiogenic activity. Results: Finally, we examined the inhibitory potential of hexasaccharides and octasaccharides given at 20 mg/kg/d and these inhibited the growth of H460 lung carcinoma in vivo. At clinically attainable concentrations, significant anticoagulation (activated partial thromboplastin time, anti–factor Xa, and anti–factor IIa) was not observed in vitro unless species containing ≥16 saccharide residues were investigated. Conclusions: Thus, our preclinical data show that heparin octasaccharides represent novel antiangiogenic compounds that can be given without the anticoagulant effects of low molecular weight heparin.
MEDICAL NEWS
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In Vitro Evolution Reveals Noncationic Protein–RNA Interaction Mediated by Metal Ions
Authors: Valerio G Giacobelli, Kosuke Fujishima, Martin Lepšík, Vyacheslav Tretyachenko, Tereza Kadavá, Mikhail Makarov, Lucie Bednárová, Petr Novák, Klára Hlouchová
Journal: Molecular Biology and Evolution (2022)

RNA-peptide/protein interactions have been of utmost importance to life since its earliest forms, reaching even before the last universal common ancestor (LUCA). However, the ancient molecular mechanisms behind this key biological interaction remain enigmatic because extant RNA-protein interactions rely heavily on positively charged and aromatic amino acids that were absent (or heavily under-represented) in the early pre-LUCA evolutionary period. Here, an RNA-binding variant of the ribosomal uL11 C-terminal domain was selected from an approximately 1010 library of partially randomized sequences, all composed of ten prebiotically plausible canonical amino acids. The selected variant binds to the cognate RNA with a similar overall affinity although it is less structured in the unbound form than the wild-type protein domain. The variant complex association and dissociation are both slower than for the wild-type, implying different mechanistic processes involved. The profile of the wild-type and mutant complex stabilities along with molecular dynamics simulations uncovers qualitative differences in the interaction modes. In the absence of positively charged and aromatic residues, the mutant uL11 domain uses ion bridging (K+/Mg2+) interactions between the RNA sugar-phosphate backbone and glutamic acid residues as an alternative source of stabilization. This study presents experimental support to provide a new perspective on how early protein-RNA interactions evolved, where the lack of aromatic/basic residues may have been compensated by acidic residues plus metal ions.
Diagnosis and treatment of eczema
Authors: R. L. Dobson
Journal: JAMA (1976)

ECZEMA is a difficult word to define because it has been applied to a heterogeneous group of disorders. From its Greek derivation, eczema means the "result of boiling out or over." Thus, the weeping, vesiculobullous, acute, poison ivy eruption is clearly a type of eczema, but the term is also used to describe a chronic, localized, lichenified plaque of lichen simplex chronicus in which "boiling over" is hardly descriptive. To deal with this dilemma, many dermatologists simply define eczema as "anything that looks like eczema." In other words, "eczema" is a functional term whose meaning, we hope, will become clearer as its clinical manifestations are discussed. <h3>Classification</h3> Although a number of classifications have been proposed, none has been generally accepted. Perhaps the simplest and most useful is the following: Contact dermatitis includes (1) allergic and (2) irritant forms. Noncontact dermatitis includes (1) atopic dermatitis and (2) nonatopic dermatitis, eg, lichen
Undergraduate Medical Education
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Long-term Evolution of Estimated Glomerular Filtration Rate in Patients With Antiviral Treatment for Hepatitis C Virus Infection
Authors: Chen-Hua Liu, Jou-Wei Lin, Chun-Jen Liu, Tung-Hung Su, Jo-Hsuan Wu, Tai-Chung Tseng, Pei-Jer Chen, Jia-Horng Kao
Journal: Clinical Gastroenterology and Hepatology (2022)
Chemerin Tips the Scales in ccRCC to Evade Ferroptosis
Authors: Ed Reznik, Hui Jiang, A. Ari Hakimi
Journal: Cancer Discovery (2021)

Obesity is both a risk factor for the development of the most common form of kidney cancer, clear cell renal cell carcinoma (ccRCC), and a prognostically protective factor for clinical outcomes. In this issue of Cancer Discovery, Tan and colleagues identify the tumor- and adipose-derived adipokine chemerin as a circulating mediator of ccRCC lipid metabolism and ferroptotic susceptibility that may clarify the paradoxical relationship between ccRCC and obesity.See related article by Tan et al., p. 2072.
Selected New Books
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tuberculosis
Authors: Madhukar Pai, Marcel A. Behr, David Dowdy, Keertan Dheda, Maziar Divangahi, Catharina C. Boehme, Ann Ginsberg, Soumya Swaminathan, Melvin Spigelman, Haileyesus Getahun, Dick Menzies, Mario Raviglione
Journal: Nature Reviews Disease Primers (2016)
The Attacks on the American Medical Association.
Authors: J. H. Carstens
Journal: JAMA (1906)

Detroit, Aug. 1, 1906. <h3>To the Editor:</h3> —In traveling I meet many members of our Association and hear a good deal of criticism of the management, which pains me very much, and obliges me to defend the organization, and where there is so much talk there must be some cause for it. I also read in the journals a good deal of criticism, and can readily see how it is caused. Undoubtedly a great deal comes from the manufacturers who are financially injured by being exposed; the other comes from the independent journals who resent the statement that there is no use for their existence. In the case of the manufacturers, few will defend them, and I think everybody believes that the good work should go on and be amplified if necessary. As far as the independent journals are concerned, I certainly think there is a place for them. First,