tbuckley/cabot-search huggingface dataset:
Low-molecular-weight heparin use in coronavirus disease 2019 is associated with curtailed viral persistence: a retrospective multicentre observational study
Authors: David Pereyra, Stefan Heber, Waltraud C Schrottmaier, Jonas Santol, Anita Pirabe, Anna Schmuckenschlager, Kerstin Kammerer, Daphni Ammon, Thomas Sorz, Fabian Fritsch, Hubert Hayden, Erich Pawelka, Philipp Krüger, Benedikt Rumpf, Marianna T Traugott, Pia Glaser, Christa Firbas, Christian Schörgenhofer, Tamara Seitz, Mario Karolyi, Ingrid Pabinger, Christine Brostjan, Patrick Starlinger, Günter Weiss, Rosa Bellmann-Weiler, Helmut J F Salzer, Bernd Jilma, Alexander Zoufaly, Alice Assinger
Journal: Cardiovascular Research (2021)

Anticoagulation was associated with improved survival of hospitalized coronavirus disease 2019 (COVID-19) patients in large-scale studies. Yet, the development of COVID-19-associated coagulopathy (CAC) and the mechanism responsible for improved survival of anticoagulated patients with COVID-19 remain largely elusive. This investigation aimed to explore the effects of anticoagulation and low-molecular-weight heparin (LMWH) in particular on patient outcome, CAC development, thromboinflammation, cell death, and viral persistence.Data of 586 hospitalized COVID-19 patients from three different regions of Austria were evaluated retrospectively. Of these, 419 (71.5%) patients received LMWH and 62 (10.5%) received non-vitamin-K oral anticoagulants (NOACs) during hospitalization. Plasma was collected at different time points in a subset of 106 patients in order to evaluate markers of thromboinflammation (H3Cit-DNA) and the cell death marker cell-free DNA (cfDNA). Use of LMWH was associated with improved survival upon multivariable Cox regression (hazard ratio = 0.561, 95% confidence interval: 0.348-0.906). Interestingly, neither LMWH nor NOAC was associated with attenuation of D-dimer increase over time, or thromboinflammation. In contrast, anticoagulation was associated with a decrease in cfDNA during hospitalization, and curtailed viral persistence was observed in patients using LMWH leading to a 4-day reduction of virus positivity upon quantitative polymerase chain reaction [13 (interquartile range: 6-24) vs. 9 (interquartile range: 5-16) days, P = 0.009].Time courses of haemostatic and thromboinflammatory biomarkers were similar in patients with and without LMWH, indicating either no effects of LMWH on haemostasis or that LMWH reduced hypercoagulability to levels of patients without LMWH. Nonetheless, anticoagulation with LMWH was associated with reduced mortality, improved markers of cell death, and curtailed viral persistence, indicating potential beneficial effects of LMWH beyond haemostasis, which encourages use of LMWH in COVID-19 patients without contraindications.
563TiP A phase I, first in human (FIH) study of adenovirally transduced autologous macrophages engineered to contain an anti-HER2 chimeric antigen receptor (CAR) in subjects with HER2 overexpressing solid tumors
Authors: K.R. Binder, D. Barton, A. Ronczka, D. Cushing, M. Klichinsky, C. Dees
Journal: Annals of Oncology (2021)
1649P Anlotinib plus oral fluoropyrimidine S1 in treating patients with refractory or relapsed small cell lung cancer (SALTER TRIAL): An open-label, multicenter, single-arm, phase II trial
Authors: W. Wang, D. Lv, X. Wu, J. Ye, C. Zhou, J. Wang, L. Ling, H. Yang
Journal: Annals of Oncology (2021)
International Tailored Chemotherapy Adjuvant (ITACA) trial, a phase III multicenter randomized trial comparing adjuvant pharmacogenomic-driven chemotherapy versus standard adjuvant chemotherapy in completely resected stage II-IIIA non-small-cell lung cancer
Authors: S. Novello, V. Torri, C. Grohe, S. Kurz, M. Serke, T. Wehler, A. Meyer, D. Ladage, M. Geissler, I. Colantonio, C. Cauchi, E. Stoelben, A. Ceribelli, C. Kropf-Sanchen, G. Valmadre, G. Borra, M. Schena, A. Morabito, A. Santo, V. Gregorc, R. Chiari, M. Reck, G. Schmid-Bindert, G. Folprecht, F. Griesinger, A. Follador, P. Pedrazzoli, A. Bearz, O. Caffo, N.J. Dickgreber, L. Irtelli, G. Wiest, V. Monica, L. Porcu, C. Manegold, G.V. Scagliotti
Journal: Annals of Oncology (2021)
453P Routine DPYD mutation testing for patients receiving fluoropyrimidines for gastrointestinal (GI) cancers: Real world experience in a tertiary UK oncology centre
Authors: D.K.W. Lau, C. Fong, F. Arouri, L. Cortez, H. Katifi, R. Gonzalez-Exposito, M.B. Razzaq, S. Li, A. Macklin-Doherty, C. Fribbens, D. Watkins, S. Rao, I. Chau, D. Cunningham, N. Starling
Journal: Annals of Oncology (2021)
1521O A phase II biomarker-driven study evaluating the clinical efficacy of an MDM2 inhibitor, milademetan, in patients with intimal sarcoma, an ultra-rare cancer with highly life-threatening unmet medical needs (NCCH1806/MK004)
Authors: Y. Kojima, T. Shimizu, K. Yonemori, T. Koyama, N. Matsui, M. Kamikura, S. Tomatsuri, H.S. Okuma, T. Shimoi, E. Noguchi, K. Sudo, A. Hirakawa, R. Sadachi, N.T. Okita, K. Nakamura, N. Yamamoto, Y. Fujiwara
Journal: Annals of Oncology (2021)
Author Correction: Exercise hormone irisin is a critical regulator of cognitive function
Authors: Mohammad R. Islam, Sophia Valaris, Michael F. Young, Erin B. Haley, Renhao Luo, Sabrina F. Bond, Sofia Mazuera, Robert R. Kitchen, Barbara J. Caldarone, Luis E. B. Bettio, Brian R. Christie, Angela B. Schmider, Roy J. Soberman, Antoine Besnard, Mark P. Jedrychowski, Hyeonwoo Kim, Hua Tu, Eunhee Kim, Se Hoon Choi, Rudolph E. Tanzi, Bruce M. Spiegelman, Christiane D. Wrann
Journal: Nature Metabolism (2021)
223P Pregnancy-associated breast cancer: A single centre experience
Authors: I. Peixoto, M.J. Ramos, R. Ranchor, R. Romão, A.S. Mendes, J. Simões, F. Gonçalves, J.R. Alves, G. Ferreira, J. Polónia, N. Afonso, A. Araújo
Journal: Annals of Oncology (2021)
1824P Attitudes, knowledge, and need for education about LGBTQ patients with cancer: A survey by the ESMO/SIOPE AYA with cancer Working Group
Authors: E. Saloustros, A. Ferrari, I. Bozovic-Spasojevic, N. Gaspar, G. Mountzios, A. Blondeel, S. Bielack, D. Stark, S. Jezdic, F.A. Peccatori
Journal: Annals of Oncology (2021)
1528P Prospective IAWS registry to optimize either neo- or adjuvant treatment strategies for adult patients with large sized, high grade soft tissue sarcoma (NRSTS)
Authors: J.T. Hartmann, H-G. Kopp, V. Budach, V. Grünwald, T. Wölfel, T. Kluba, M. Rudert, I. Melcher, O. Micke, D. Kürschner, R. Herbst, B. Hertenstein, W. Blau, A. Serrano, J. Groth, A. Kunitz
Journal: Annals of Oncology (2021)
1211P Indirect comparison of mobocertinib and standard of care in platinum-pretreated patients with NSCLC with EGFR exon 20 insertion
Authors: S-H.I. Ou, H.M. Lin, J-L. Hong, Y. Yin, S. Jin, J. Lin, M. Mehta, D. Nguyen, J.W. Neal
Journal: Annals of Oncology (2021)
892P The genomic features of Chinese oropharyngeal squamous cell carcinomas and the implications for therapy
Authors: Q. Li, T. Cai, L. Zhang, N. Liu, R. Chen, Z. Xie, J. Huang, X. Zhang, T. He, H. Cao, Y. Li, T. Lan, S. Xie, Y. Peng, B. Li, J. Wu, J. Li, F. Liang, S. Fan
Journal: Annals of Oncology (2021)
Assessment of Breathomics Testing Using High-Pressure Photon Ionization Time-of-Flight Mass Spectrometry to Detect Esophageal Cancer
Authors: Qi Huang, Shaodong Wang, Qingyun Li, Peiyu Wang, Jianfeng Li, Shushi Meng, Hang Li, Hao Wu, Yu Qi, Xiangnan Li, Yang Yang, Song Zhao, Mantang Qiu
Journal: JAMA Network Open (2021)

A triage test is needed to increase the detection rate for esophageal cancer.To investigate whether breathomics can detect esophageal cancer among patients without a previous diagnosis of cancer using high-pressure photon ionization time-of-flight mass spectrometry (HPPI-TOFMS).This diagnostic study included participants who planned to receive an upper endoscopy or surgery of the esophagus at a single center in China. Exhaled breath was collected with a self-designed collector and air bags before participants underwent these procedures. Sample collection and analyses were performed by trained researchers following a standardized protocol. Participants were randomly divided into a discovery data set and a validation data set. Data were collected from December 2020 to March 2021.Breath samples were analyzed by HPPI-TOFMS, and the support vector machine algorithm was used to construct a detection model.The accuracy of breathomics was measured by the sensitivity, specificity, accuracy, positive predictive value, negative predictive value, and area under the receiver operating characteristic curve.Exhaled breath samples were obtained from 675 patients (216 [32%] with esophageal cancer; 459 [68%] with noncancer diseases). Of all patients, 206 (31%) were women, and the mean (SD) age was 64.0 (11.9) years. In the validation data set, esophageal cancer was detected with an accuracy of 93.33%, sensitivity of 97.83%, specificity of 83.72%, positive predictive value of 94.74%, negative predictive value of 92.78%, and area under the receiver operating characteristic curve of 0.89. Notably, for 16 patients with high-grade intraepithelial neoplasia, 12 (75%) were predicted to have esophageal cancer.In this diagnostic study, testing breathomics using HPPI-TOFMS was feasible for esophageal cancer detection and totally noninvasive, which could help to improve the diagnosis of esophageal cancer.
Extramural extension of a buried over-the-scope clip in the stomach: an unusual adverse event
Authors: Giuliano Francesco Bonura, Paola Soriani, Paolo Biancheri, Tommaso Gabbani, Mauro Manno
Journal: Endoscopy (2021)

An 82-year-old woman with a 25-mm gastrointestinal stromal tumor (GIST) in the gastric body ([Fig. 1, ] [Fig. 2]) underwent curative endoscopic submucosal enucleation. As the lesion originated deep within the gastric wall, a 15-mm full-thickness defect occurred ([Fig. 3]). The defect was completely sealed with the omental patch technique using one over-the scope clip (OTSC) (11/6t; Ovesco Endoscopy, Tuebingen, Germany) and six through-the-scope clips (Meditalia, Italy) ([Fig. 4]). The patient remained asymptomatic after the procedure and was discharged home 2 days later.
1572P The impact of COVID-19 pandemic on Spanish genitourinary (GU) cancer patients: SOGUG-COVID-19 study
Authors: M.A. Climent Duran, N. Vidal, S. Pérez, M.J. Méndez-Vidal, G. Anguera, I. Martinez Salas, E. Gallardo, M.A. Cuellar, J.J. Soto, A. Martín, M. Domènech, A. Rodriguez-Vida, E. Almagro Casado, N. Diaz-Mejía, M. Martinez Kareaga, O. Fernandez Calvo, J.C. Villa Guzmán, S. Vazquez, A. Gonzalez del Alba, J. Puente
Journal: Annals of Oncology (2021)
27P Oxidized low-density lipoprotein induces cell dead and inflammation in cardiomyocytes exposed to nivolumab by TLR4/NF-κB and NLRP3/myd88 pathways
Authors: M. Iovine, S. Buccolo, A. Paccone, F. Cerrone, N. Maurea
Journal: Annals of Oncology (2021)
639TiP KEYNOTE-365 cohort I: Phase Ib/II study of platinum containing chemotherapy in combination with pembrolizumab and chemotherapy alone for treatment-emergent neuroendocrine prostate carcinoma (t-NE)
Authors: N.D. Shore, G. Kramer, A.M. Joshua, X.T. Li, C.H. Poehlein, C. Schloss, J.S. de Bono, E. Yu
Journal: Annals of Oncology (2021)
Nanocomposite electrospun fibers of poly(ε-caprolactone)/bioactive glass with shape memory properties
Authors: Liliana Liverani, Anna Liguori, Paola Zezza, Chiara Gualandi, Maurizio Toselli, Aldo R. Boccaccini, Maria Letizia Focarete
Journal: Bioactive Materials (2021)

Electrospun fibers of shape memory triethoxysilane-terminated poly(epsilon-caprolactone) (PCL-TES) loaded with bioactive glasses (BG) are here presented. Unloaded PCL-TES, as well as PCL/BG nanocomposite fibers, are also considered for comparison. It is proposed that hydrolysis and condensation reactions take place between triethoxysilane groups of the polymer and the silanol groups at the BG particle surface, thus generating additional crosslinking points with respect to those present in the PCL-TES system. The as-spun PCL-TES/BG fibers display excellent shape memory properties, in terms of shape fixity and shape recovery ratios, without the need of a thermal crosslinking treatment. BG particles confer in vitro bioactivity to PCL-based nanocomposite fibers and favor the precipitation of hydroxycarbonate apatite on the fiber surface. Preliminary cytocompatibility tests demonstrate that the addition of BG particles to PCL-based polymer does not inhibit ST-2 cell viability. This novel approach of using bioactive glasses not only for their biological properties, but also for the enhancement of shape memory properties of PCL-based polymers, widens the versatility and suitability of the obtained composite fibers for a huge portfolio of biomedical applications.
ANKRD36 Is Involved in Hypertension by Altering Expression of ENaC Genes
Authors: Yupeng Yan, Jin’e Wang, Liang Yu, Bing Cui, Hongrui Wang, Xiao Xiao, Yu Zhang, Jun Zheng, Jingjun Wang, Rutai Hui, Yibo Wang
Journal: Circulation Research (2021)

Rationale: Hypertension is the most important risk factor for cardiovascular and cerebrovascular diseases. Getting deep insight into the pathogenesis of hypertension is necessary. Objective: To investigate the role of ANK (ankyrin) repeat domain 36 ( ANKRD36 ) in hypertension. Methods and Results: We first recruited an essential hypertension cohort and then performed genome-wide transcriptome analysis with peripheral blood mRNA. ANKRD36 was found to be significantly lower expressed in hypertension. The anchorin repeat domain mediates a variety of protein-protein interactions. The ENaC (epithelial sodium channel) genes expression was found upregulated in human umbilical vein endothelial cells with ANKRD36 knockdown by using Affymetrix expression profile chip. In human embryonic kidney epithelial cells and HEK293T (human embryonic kidney cells), ANKRD36 overexpression significantly downregulated expression of ENaC genes, and ANKRD36 knockdown upregulated their expression. The chromosome immunoprecipitation assay and yin yang 1 ( YY1 ) knockdown showed the expression of ENaC was regulated by ANKRD36 via YY1, a dual-function transcription factor ubiquitously expressed in human tissues. Immunocoprecipitation and fluorescence resonance energy transfer assay confirmed the interaction between ANKRD36 and YY1. The nucleo-cytoplasmic ratio of YY1 decreased when ANKRD36 was overexpressed and also increased when ANKRD36 was knocked down. ANK2 domain of ANKRD36 was critical to its interaction with YY1. Ankrd36 knockout mice showed higher blood pressure levels and Na + reabsorption, especially when fed with high-salt diet. Higher expression of ENaC genes was observed in renal tubular epithelial cells from the knockout mice, and Yy1 knockdown mitigated the alteration. Ankrd36 knockout mice also showed more sensitive response to ENaC inhibitor amiloride treatment. Conclusions: We identified that ANKRD36 was involved in blood pressure regulation by interacting with YY1 and then altering expression of ENaC genes. Lower expressed ANKRD36 in hypertension might be a potential therapeutic target, and the application of ENaC inhibitors on hypertension treatment might be extended when serum K + levels are closely monitored.
739P Efficacy and safety of maintenance olaparib and bevacizumab (bev) in ovarian cancer (OC) patients (pts) aged ≥65 years (y) from the PAOLA-1/ENGOT-ov25 first-line trial
Authors: R. Sabatier, F. Rousseau, F. Joly, C. Cropet, C. Montegut, J. Frindte, S. Cinieri, E.M. Guerra-Alia, G. Bogner, H. Yoshida, I. Vergote, N. Colombo, S. Hietanen, R. Largillier, U. Canzler, A. Gratet, F. Marmé, E. Pujade-Lauraine, L. Favier, I.L. Ray-Coquard
Journal: Annals of Oncology (2021)
1415P Performance of a tumor-informed circulating tumor DNA assay from over 250 patients with over 600 plasma time points in esophageal and gastric cancer
Authors: B.M. Huffman, G. Budde, J. Chao, F. Dayyani, D. Hanna, G. Botta, S. Krinshpun, S. Sharma, V. Aushev, T. Farmer, H. Pela, M. Tavallai, M. Goodman, K. Baker, B. Drummond, A. Aleshin, P.M. Kasi, S.J. Klempner
Journal: Annals of Oncology (2021)
Dual Extrusion Patterning Drives Tissue Development Aesthetics and Shape Retention in 3D Printed Nipple‐Areola Constructs
Authors: Sarah Van Belleghem, Bhushan Mahadik, Kirstie Snodderly, Zoe Mote, Bin Jiang, Justine R. Yu, Shannon McLoughlin, Xiaoming He, Arthur J. Nam, John P. Fisher
Journal: Advanced Healthcare Materials (2021)

Breast cancer and its most radical treatment, the mastectomy, significantly impose both physical transformations and emotional pain in thousands of women across the globe. Restoring the natural appearance of a nipple-areola complex directly on the reconstructed breast represents an important psychological healing experience for these women and remains an unresolved clinical challenge, as current restorative techniques render a flattened disfigured skin tab within a single year. To provide a long-term solution for nipple reconstruction, this work presents 3D printed hybrid scaffolds composed of complementary biodegradable gelatin methacrylate and synthetic non-degradable poly(ethylene) glycol hydrogels to foster the regeneration of a viable nipple-areola complex. In vitro results showcased the robust structural capacity and long-term shape retention of the nipple projection amidst internal fibroblastic contraction, while in vivo subcutaneous implantation of the 3D printed nipple-areola demonstrated minimal fibrotic encapsulation, neovascularization, and the formation of healthy granulation tissue. Envisioned as subdermal implants, these nipple-areola bioprinted regenerative grafts have the potential to transform the appearance of the newly reconstructed breast, reduce subsequent surgical intervention, and revolutionize breast reconstruction practices.
The effect of drug loading and multiple administration on the protein corona formation and brain delivery property of PEG-PLA nanoparticles
Authors: Yuyun Tang, Jinchao Gao, Tao Wang, Qian Zhang, Antian Wang, Meng Huang, Renhe Yu, Hongzhuan Chen, Xiaoling Gao
Journal: Acta Pharmaceutica Sinica B (2021)

The presence of protein corona on the surface of nanoparticles modulates their physiological interactions such as cellular association and targeting property. It has been shown that α-mangostin (αM)-loaded poly(ethylene glycol)-poly(l-lactide) (PEG-PLA) nanoparticles (NP-αM) specifically increased low density lipoprotein receptor (LDLR) expression in microglia and improved clearance of amyloid beta (Aβ) after multiple administration. However, how do the nanoparticles cross the blood‒brain barrier and access microglia remain unknown. Here, we studied the brain delivery property of PEG-PLA nanoparticles under different conditions, finding that the nanoparticles exhibited higher brain transport efficiency and microglia uptake efficiency after αM loading and multiple administration. To reveal the mechanism, we performed proteomic analysis to characterize the composition of protein corona formed under various conditions, finding that both drug loading and multiple dosing affect the composition of protein corona and subsequently influence the cellular uptake of nanoparticles in b.End3 and BV-2 cells. Complement proteins, immunoglobulins, RAB5A and CD36 were found to be enriched in the corona and associated with the process of nanoparticles uptake. Collectively, we bring a mechanistic understanding about the modulator role of protein corona on targeted drug delivery, and provide theoretical basis for engineering brain or microglia-specific targeted delivery system.
1141P Prediction of cancer genomic instability using MALDI-imaging
Authors: W. Kassuhn, O. Klein, R. Ganapathi, D. Cacsire Castillo-Tong, D. Horst, M. Hummel, L. Heukamp, W. Weichert, C. Vollbrecht, H. Kulbe, J. Sehouli, E.I. Braicu
Journal: Annals of Oncology (2021)
P-157 Assessing fitness for systemic therapy in hepatocellular carcinoma: Evaluating time on treatment according to Child-Pugh classification, model for end-stage liver disease score, and AFP level
Authors: B. Staum, J. Hu, A. Leal, S. Kim, W. Purcell, C. Lieu, W. Messersmith, S. Davis
Journal: Annals of Oncology (2021)
Archway Randomized Phase 3 Trial of the Port Delivery System with Ranibizumab for Neovascular Age-Related Macular Degeneration
Authors: Nancy M. Holekamp, Peter A. Campochiaro, Margaret A. Chang, Daniel Miller, Dante Pieramici, Anthony P. Adamis, Christopher Brittain, Erica Evans, Derrick Kaufman, Katie F. Maass, Shienal Patel, Shrirang Ranade, Natasha Singh, Giulio Barteselli, Carl Regillo
Journal: Ophthalmology (2021)
436P Phase (Ph) II study of taminadenant (NIR178) + spartalizumab (PDR001) in patients (pts) with microsatellite stable (MSS) colorectal cancer (CRC)
Authors: O. Saavedra Santa Gadea, R. Greil, M.J.A. de Jonge, D. Tan, G. Jerusalem, S. Damian, P. Grell, Z. Wainberg, J. Wolf, M. Joerger, M.S. Carlino, S. Kasper, T.A. Yap, J. Otero, X. Yang, V. Nesbitt, J. Kim, L. Ho Lee, S. Choudhury, T.A. Leal
Journal: Annals of Oncology (2021)
1270P Genomic alterations of bone metastases in stage IV non-small cell lung cancer (NSCLC) and real-world outcomes
Authors: P.J. Voon, G.J. Riely, E.M. Lepisto, J.A. Lavery, J.L. Warner, M.L. LeNoue-Newton, S.M. Sweeney, C.G. McCarthy, B. Samantha, K.S. Panageas, J. Weiss, C. Yu, A. Sacher, K.L. Kehl, N. Leighl, D. Schrag, P. Bedard
Journal: Annals of Oncology (2021)
614P Circulating tumor cell (CTC) morphologic sub-types present prior to treatment in the CARD trial identify therapy resistance
Authors: J.S. de Bono, K. Pantel, E. Efstathiou, C.N. Sternberg, D. Castellano Gauna, K. Fizazi, B. Tombal, C. Wülfing, J.D. Schonhoft, A. Tubbs, L. Chu, R. Wenstrup, A. Ozatilgan, C. Geffriaud-Ricouard, S. Macé, R. de Wit
Journal: Annals of Oncology (2021)
996P An immune-metabolic signature correlates with immune-suppressive patterns and with outcome, across tumor types
Authors: L. Pedrosa, C. Foguet, H. Oliveres, I. Archilla, M. García de Herreros, A. Rodriguez, A. Postigo, D. Benítez-Ribas, J. Camps, M. Cuatrecasas, A. Castells, A. Prat, T.M. Thomson, J. Maurel, M. Cascante
Journal: Annals of Oncology (2021)