tbuckley/cabot-search huggingface dataset:
LNA -Gapmer Antisense Oligonucleotides Targeting the Oncogenic Lncrna MALAT1 Trigger Anti-Multiple Myeloma Activity By Proteasome Blockade
Authors: Nicola Amodio, Maria Angelica Stamato, Giada Juli, Eugenio Morelli, Martina Manzoni, Elisa Taiana, Marco Rossi, Mariamena Arbitrio, Mariateresa Fulciniti, Nikhil Munshi, Antonino Neri, Pierosandro Tagliaferri, Pierfrancesco Tassone
Journal: Blood (2017)
Modulating serine palmitoyltransferase‐deoxysphingolipid axis in cancer therapy
Authors: Yuancai Xiang, Kun Zhao, Yi‐Quan Tang, Rongyang Dai, Hongming Miao
Journal: MedComm (2020)

A schematic illustration is given regarding serine restriction on tumor growth. Once the cellular abundance of serine decreased or alanine accumulated, the serine palmitoyltransferase (SPT) alternatively conjugates alanine and palmitoyl-CoA to form 3-keto-intermediates, which is rapidly converted to 1-deoxysphinganine and further metabolized to 1-deoxydihydroceramide (1-DeoxyDHCER) and 1-deoxyceramide (1-DeoxyDHCER), so that to exert cytotoxicity for tumor suppression.
A Lesson From 2020: Public Health Matters for Both COVID-19 and Diabetes
Authors: Matthew C. Riddle, George Bakris, Lawrence Blonde, Andrew J.M. Boulton, David D’Alessio, Linda A. DiMeglio, Linda Gonder-Frederick, Korey K. Hood, Frank B. Hu, Steven E. Kahn, Sanjay Kaul, Lawrence A. Leiter, Robert G. Moses, Stephen S. Rich, Julio Rosenstock, Judith Wylie-Rosett
Journal: Diabetes Care (2020)

Each January, the editors of Diabetes Care look back at the last year and forward to the next. In January 2021 we have much to be thankful and happy about. The journal continues to publish outstanding scientific reports together with illuminating and provocative Commentary, Perspective, and Review articles. We are indebted to the authors who submit their manuscripts, the reviewers who evaluate them, and the editorial and production group that manages the process. They make it all possible. In 2020, Diabetes Care ’s impact factor increased once again, from 15.27 to 16.02. Accumulating scientific evidence presented by our journal and others continues to improve understanding of the pathophysiology of diabetes and add to the array of treatments.

And yet . . . it’s been a hell of a year in other ways. The coronavirus disease 2019 (COVID-19) pandemic started a year ago and still has the world in its grip. It has tested all of us and brought many activities nearly to a halt. Countless people have fallen ill, sadly many have died, and the daily routines of most families are disturbed. The lockdown to prevent spread of the virus keeps people at home, limits travel, harms businesses, closes schools, and interferes with diagnosis and treatment of other ailments. Acute medical facilities have been overwhelmed in some regions. Fierce debates about controlling the spread of COVID-19 and mitigating its human and economic costs have ensued. Yet, in this crisis we see much heroism. Medical personnel and those who support …
Abstract 13754: Elderly Patients With Heart Failure With Low Ejection Fraction and Renal Impairment: Does the Standard Treatment Work?
Authors: Juan Martinez-Milla, Marcelino Cortés, Marta López-Castillo, Ana Devesa, Ana L Rivero, Juan A Franco, Mikel Taibo, Maria L Martín-Mariscal, Jerónimo Farré
Journal: Circulation (2017)

Introduction: Beta-blockers (BB) have demonstrated to reduce mortality in patients with heart failure and low ejection fraction. However, there are few data about the benefit of these therapies in ...
Multifunctional ginsenoside Rg3-based liposomes for glioma targeting therapy
Authors: Ying Zhu, Jianming Liang, Caifang Gao, Anni Wang, Jiaxuan Xia, Chao Hong, Zhirong Zhong, Zhong Zuo, Jisu Kim, Hongwei Ren, Shiyi Li, Qi Wang, Fengxue Zhang, Jianxin Wang
Journal: Journal of Controlled Release (2020)
원저 : 화농성 간농양의 원인균 및 치료의 최근 변화
Authors: 나병규 ( Na Byeonggyu ), 김연수 ( Kim Yeonsu ), 문희석 ( Mun Huiseog ), 박기오 ( Park Gio ), 김선문 ( Kim Seonmun ), 이엄석 ( Lee Eomseog ), 양현웅 ( Yang Hyeonung ), 서승원 ( Seo Seungwon ), 김석현 ( Kim Seoghyeon ), 이병석 ( Lee Byeongseog ), 김남재 ( Kim Namjae ), 이헌영 ( Lee)
Journal: Clinical and Molecular Hepatology (2003)

목적: 최근의 간농양 환자들의 임상상, 원인 및 치료에 대해 분석하여 기존의 보고와 비교함으로써 변화의 유무를 보고자 하였다. 대상과 방법: 1996년 3월부터 2001년 9월까지 5년간 본원에 입원하여 화농성 간농양으로 치료를 받은 94예를 대상으로 연령, 성별, 증상, 신체검사 소견, 검사실 소견, 세균학적 검사, 동반질환, 감염경로, 농양의 특징, 치료법, 합병증 및 예후 등을 분석하였다. 결과: 평균 연령은 60?4세였으며 남자가 55명 여자가 39명으로 남녀 비는 1.4:1이었다. 남자에서는 50대에서 가장 많이 발생했으며 여자인 경우는 60대에서 빈도가 가장 높았다. 임상증상은 발열(79.8%), 오한(43.6%)이 신체검사 소견으로 발열(53.2%), 상복부 압통(44.7%)이 흔하였다. 농양이 단발성인 경우가 85.1%이었고. 우엽에만 있었던 경우가 70.3%이었다. 84예 중 67예에서 배양이 되어서 78.8%의 양성율을 보였고 단일 균주였으며 Klebsiella pneumoniae 44예(65.7%), E. coli 11예(16.4%)였다. 동반질환은 당뇨병이 14예, 악성 종양이 10예(간담도계 7예, 간세포암 2예, 직장암 1예), 담낭 절제술을 시행 받았던 예가 2예, 간경변증 1예, 만성 신부전 1예, 다낭성 신증 1예 및 막성 사구체 신염 1예였다. 원인을 찾지 못했던 예가 70예(74.5%)로 가장 흔하였으며, 상행성 전파가 20예(21.3%), 혈행성 3예(3.2%) 및 직접 전파된 경우가 1예(1.1%)였다. 경피적 배액술을 시행한 경우가 69예(73.4%), 경피적 흡인술을 시행한 경우는 15예(16.0%), 경피적 배액술과 경피적 흡인술을 같이 시행한 경우는 2예(2.1%), 항생제 치료만을 시행한 8예(8.5%)였다. 경피적 배액술을 시행한 예중 6예(8.7%), 경피적 흡인술을 시행한 예중 2예(13.3%), 항생제만 쓴 경우는 1예(1.3%), 총 9예(9.6%)에서 사망 또는 가망이 없어서 퇴원하였다. 호흡기 합병증이 23예(24.5%)로 가장 흔하였고 급성 신부전이 4예, 복막염은 3예, 농양의 파열이 2예, 치료적 시술이 필요한 답즙낭 발생이 2예 및 횡격막하 농양의 발생이 1예에서 있었다. 결론: 최근의 화농성 간농양에서 Klebsiella pneumoniae가 가장 흔한 균이며 일차적인 치료로는 경피적 배농술(경피적 도관 배액술, 경피적 흡인 천자)을 선택할 수 있을 것으로 판단된다.
Chidamide, a Novel Histone Deacetylase Inhibitor, Combined with Imatinib Induces Synthetic Lethality in Drug-Resistant Chronic Myeloid Leukemia
Authors: Bolin He, Qiang Wang, Na Xu, Ziyuan Lu, Chengyun Pan, Jing Sun, Hongsheng Zhou, Liu Xiaoli
Journal: Blood (2017)
Re-evaluating positive serum samples for SARS-CoV-2-specific IgA and IgG antibodies using an in-house serological assay
Authors: Margherita Cacaci, Giulia Menchinelli, Rosalba Ricci, Flavio De Maio, Melinda Mariotti, Riccardo Torelli, Grazia Angela Morandotti, Francesca Bugli, Maurizio Sanguinetti, Brunella Posteraro
Journal: Clinical Microbiology and Infection (2021)
Corrigendum to “In vitro and in vivo anti-biofilm effects of silver nanoparticles immobilized on titanium” [Biomaterials (2014) 9114–9125]
Authors: Hui Qin, Huiliang Cao, Yaochao Zhao, Cheng Zhu, Tao Cheng, Qiaojie Wang, Xiaochun Peng, Mengqi Cheng, Jiaxin Wang, Guodong Jin, Yao Jiang, Xianlong Zhang, Xuanyong Liu, Paul K. Chu
Journal: Biomaterials (2020)
Trends in Fever and Respiratory Illness in Hemodialysis Patients During the COVID-19 Pandemic
Authors: Sheetal Chaudhuri, Hao Han, John W. Larkin, Len A. Usvyat, Dinesh K. Chatoth, Jeffrey L. Hymes, Michael A. Kraus, Allan J. Collins, Franklin W. Maddux
Journal: Journal of the American Society of Nephrology (2020)

Background: It is unclear whether end-stage kidney disease (ESKD) patients with COVID-19 are at increased risk for adverse outcomes due to impaired immune responses attributable to uremia  Alternatively, a weakened immune state could mitigate the cytokine surge observed in non-ESKD patients with COVID-19  The aim of our study is to describe the clinical characteristics and short term outcomes in ESKD patients requiring hospitalization for COVID-19  Methods: We performed a retrospective study of 114 consecutive ESKD patients hospitalized at two major hospitals in the Bronx with COVID-19 from March 9, 2020 to April 12, 2020 in the midst of the coronavirus surge in New York City  Clinical and laboratory data were extracted from the medical record and short term outcomes were reported  Results: The mean age was 63 years (range 30-87);61 4% were men and 88 6% were Black or Hispanic  Most had hypertension (89 5%) and diabetes mellitus 66% and 30 7% were nursing home residents  Intensive care unit admission was required in 13(11 4%) patients and 17(14 9%) required mechanical ventilation  In-hospital mortality occurred in 23(20%) patients and was similar to mortality observed in non-ESKD patients  Mortality was 59% in those who required mechanical ventilation  At the time of data censoring, 47% had been discharged and 32% remained hospitalized  Initial procalcitonin, ferritin, lactate dehydrogenase and lymphocyte percentage were significantly higher in those who died  Conclusions: Short term mortality in Bronx ESKD patients hospitalized with COVID-19 was similar to non-ESKD patients  Mechanical ventilation was associated with high mortality  Initial elevated inflammatory markers may be predictors of mortality in ESKD patients with COVID-19  To date, this is one of the largest studies describing outcomes in hospitalized ESKD patients with COVID-19  Further studies describing long-term outcomes in this population following COVID-19 are needed
Reply: Will Single-Cell RNAseq decipher stem cells biology in normal and cancerous tissues?
Authors: Kehkooi Kee
Journal: Human Reproduction Update (2020)

Sir, We appreciate the recognition of our review by Bhartiya et al. (2020). The main concern or question raised seems to be the commonly used procedure to collect single cells for scRNAseq might not include stem cells in various tissues. The authors cited a few studies which have not identified stem cells in adult ovary and other tissues. They suggested that the centrifugation step might be the key factor to collect stem cells if they exist in the tissues. Although it is likely that improving methodology such as centrifugation step, might ultimately help researchers to collect a rare cell population in a tissue, it is also possible that the tissues simply does not contain any stem cells. Some terminally differentiated cells such as hepatocyte may be still proliferative but they are not capable of further differentiation, so they are not stem cells which still possess cellular potency. Besides, single-cell RNAseq...
Empagliflozin restores chronic kidney disease–induced impairment of endothelial regulation of cardiomyocyte relaxation and contraction
Authors: Rio P. Juni, Rushd Al-Shama, Diederik W.D. Kuster, Jolanda van der Velden, Henrike M. Hamer, Marc G. Vervloet, Etto C. Eringa, Pieter Koolwijk, Victor W.M. van Hinsbergh
Journal: Kidney International (2020)

Chronic kidney disease (CKD) promotes development of cardiac abnormalities and is highly prevalent in patients with heart failure, particularly in those with preserved ejection fraction. CKD is associated with endothelial dysfunction, however, whether CKD can induce impairment of endothelium-to-cardiomyocyte crosstalk leading to impairment of cardiomyocyte function is not known. The sodium-glucose co-transporter 2 inhibitor, empagliflozin, reduced cardiovascular events in diabetic patients with or without CKD, suggesting its potential as a new treatment for heart failure with preserved ejection fraction. We hypothesized that uremic serum from patients with CKD would impair endothelial control of cardiomyocyte relaxation and contraction, and that empagliflozin would protect against this effect. Using a co-culture system of human cardiac microvascular endothelial cells with adult rat ventricular cardiomyocytes to measure cardiomyocyte relaxation and contraction, we showed that serum from patients with CKD impaired endothelial enhancement of cardiomyocyte function which was rescued by empagliflozin. Exposure to uremic serum reduced human cardiac microvascular endothelial cell nitric oxide bioavailability, and increased mitochondrial reactive oxygen species and 3-nitrotyrosine levels, indicating nitric oxide scavenging by reactive oxygen species. Empagliflozin attenuated uremic serum-induced generation of endothelial mitochondrial reactive oxygen species, leading to restoration of nitric oxide production and endothelium-mediated enhancement of nitric oxide levels in cardiomyocytes, an effect largely independent of sodium-hydrogen exchanger-1. Thus, empagliflozin restores the beneficial effect of cardiac microvascular endothelial cells on cardiomyocyte function by reducing mitochondrial oxidative damage, leading to reduced reactive oxygen species accumulation and increased endothelial nitric oxide bioavailability.
Клінічні особливості перебігу функціональної диспепсії за умов поєднання із бронхіальною астмою
Authors: M.V. Rostoka-Reznikova, M.I. Tovt-Korshynska, I.V. Chopei
Journal: GASTROENTEROLOGY (2020)

Метою дослідження було визначення клінічних особливостей перебігу функціональної диспепсії за умов поєднання із бронхіальною астмою. Обстежені 152 хворі на функціональну диспепсію, із них у 102 була діагностована бронхіальна астма. У пацієнтів із функціональною диспепсією, поєднаною із бронхіальною астмою, порівняно із хворими на функціональну диспепсію без бронхіальноі астми виявлено погіршення клінічного перебігу функціональної диспепсії (вірогідно вищі показники болю в епігастрії, відчуття переповнення після їжі та нудоти) та значні статеві особливості перебігу функціональної диспепсії.Відмічено вірогідне переважання постпрандіального дистрес-синдрому серед жінок із функціональною диспепсією із бронхіальною астмою порівняно з чоловіками. Серед жінок цієї групи спостерігалася також вища частота диспептичних скарг загалом і больового синдрому зокрема з більш вираженим поліморфізмом скарг щодо характеру болю (біль натще та нічний біль, біль по всьому животі і/або з іррадіацією в спину, зв’язок із вживанням гострої їжі та психоемоційним навантаженням), тоді як чоловіки цієї групи вірогідно частіше скаржилися тільки на підвищення апетиту.
Adding Heparin to Citrate in Continuous Renal Replacement Therapy May Extend Filter Lifespan in COVID-Related AKI
Authors: Eduardo d. Valle, Claudia C. Albuquerque, Carla P. Sandoval Cabrera, Giovanio V. da Silva, Igor Smolentzov, Bernardo V. Reichert, Lucia Andrade, Paulo R. Lins, Victor F. Seabra, Camila E. Rodrigues
Journal: Journal of the American Society of Nephrology (2020)

Valle, Eduardo d.; Albuquerque, Claudia C.; Sandoval Cabrera, Carla P.; da Silva, Giovanio V.; Smolentzov, Igor; Reichert, Bernardo V.; Andrade, Lucia; Lins, Paulo R.; Seabra, Victor F.; Rodrigues, Camila E. Author Information
Colorectal cancer and absolute risks
Authors: Blake J Lawrence, Elise Alexander, Hayley Grant, Moira O'Connor
Journal: Gut (2020)

In patients with novel coronavirus disease 2019 (COVID-19) referred for lung scintigraphy because of suspected pulmonary embolism (PE), there has been an ongoing debate within the nuclear medicine community as to whether and when the ventilation imaging should be performed. Indeed, whereas PE diagnosis typically relies on the recognition of ventilation–perfusion (V/P) mismatched defects, the ventilation procedure potentially increases the risk of contamination to health-care workers. The primary aim of this study was to assess the role of ventilation imaging when lung scintigraphy is performed because of suspected PE in COVID-19 patients. The secondary aim was to describe practices and imaging findings in this specific population. <b>Methods:</b> A national registry was created in collaboration with the French Society of Nuclear Medicine to collect lung scans performed on COVID-19 patients for suspected PE. The practices of departments were assessed regarding imaging protocols and aerosol precautions. A retrospective review of V/P SPECT/CT scans was then conducted. Two physicians masked to clinical information reviewed each case by sequentially viewing perfusion SPECT, perfusion SPECT/CT, and V/P SPECT/CT images. The scans were classified into 1 of the 4 following categories: patients for whom PE could reasonably be excluded on the basis of perfusion SPECT only, perfusion SPECT/CT, or V/P SPECT/CT and patients with mismatched defects suggestive of PE according to the European Association of Nuclear Medicine criteria. <b>Results:</b> Data from 12 French nuclear medicine departments were collected. Lung scans were performed between March 2020 and April 2021. Personal protective equipment and dedicated cleaning procedures were used in all departments. Of the 145 V/Q SPECT/CT scans included in the central review, PE could be excluded using only perfusion SPECT, perfusion SPECT/CT, or V/P SPECT/CT in 27 (19%), 55 (38%), and 45 (31%) patients, respectively. V/P SPECT/CT was positive for PE in 18 (12%) patients, including 12 (67%) with a low burden of PE (≤10%). <b>Conclusion:</b> In this population of COVID-19 patients assessed with lung scintigraphy, PE could confidently be excluded without the ventilation imaging in only 57% of patients. Ventilation imaging was required to confidently rule out PE in 31% of patients. Overall, the prevalence of PE was low (12%).
Patterns of Anticoagulation Use in Patients With Cancer With Atrial Fibrillation and/or Atrial Flutter
Authors: Michael G. Fradley, Kerry Ellenberg, Mohammed Alomar, Justin Swanson, Anant Kharod, Anh Thy H. Nguyen, Sara Khodor, Shreya Mishra, Linh M. Duong, Nirav Shah, Merna Armanious, Isaac B. Rhea, Matthew B. Schabath, Kevin E. Kip
Journal: JACC CardioOncology (2020)

Atrial fibrillation (AF) is a common cardiovascular complication affecting patients with cancer, but management strategies are not well established.The purpose of this retrospective cohort study was to evaluate cross-sectional patterns of anticoagulation (AC) use in patients with cancer with AF or atrial flutter (AFL) on the basis of their risk for stroke and bleeding.Patients with cancer and electrocardiograms showing AF or AFL performed at Moffitt Cancer Center in either the inpatient or outpatient setting were included in this retrospective analysis. We described percentages of AC prescription by stroke and bleeding risk, as determined by individual CHA2DS2-VASc and HAS-BLED scores, respectively. Multivariable logistic regression evaluated clinical variables independently associated with anticoagulant prescription.The prevalence of electrocardiography-documented AF or AFL was 4.8% (n = 472). The mean CHA2DS2-VASc score was 2.8 ± 1.4. Among patients with CHA2DS2-VASc scores ≥2 and HAS-BLED scores <3, 44.3% did not receive AC, and of these, only 18.3% had platelet values <50,000/μl. In multivariable analysis, older age, hypertension, prior stroke, and history of venous thromboembolism were each directly associated with AC use, while current chemotherapy use, prior bleeding, renal disease, and thrombocytopenia were each inversely associated with AC use.Nearly one-half of patients with cancer, the majority with normal platelet counts, had an elevated risk for stroke but did not receive AC. In addition to known predictors, current chemotherapy use was independently associated with a lower odds of AC use. This study highlights the need to improve the application of AF treatment algorithms to cancer populations.
Systematic Nasogastric Tube Decompression Following Pancreaticoduodenectomy—Is it Safe?
Authors: Amanda Baroutjian, Carol Sanchez, Adel Elkbuli
Journal: JAMA Surgery (2020)

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Melanin-loaded CpG DNA hydrogel for modulation of tumor immune microenvironment
Authors: Yina Wu, Qiaoyun Li, Gayong Shim, Yu-Kyoung Oh
Journal: Journal of Controlled Release (2020)

Photothermal immunotherapy has emerged as one of the most potent approaches for cancer treatment, but this strategy has suffered from the lack of biodegradability of the photoresponsive materials. In this study, we aimed to develop biodegradable materials for photothermal immunotherapy. To this end, we designed a DNA CpG hydrogel (DH, generated by rolling-circle amplification), loaded it with bis-(3′-5′)-cyclic dimeric guanosine monophosphate (G/DH), and coated the formulation with melanin (Mel/G/DH). Mel/G/DH exhibited a temperature increase upon near infrared (NIR) illumination. In vitro, Mel/G/DH plus NIR (808 nm) irradiation, induced the exposure of calreticulin on CT26 cancer cells, and significantly activated the maturation of dendritic cells (DC). In vivo, local administration of Mel/G/DH (+NIR) exerted photothermal killing of primary tumors and induced maturation of DC in lymph nodes. Treatment of primary tumors with Mel/G/DH(+NIR) prevented the growth of rechallenged tumors at a distant site. Survival was 100% in mice treated with Mel/G/DH(+NIR), 5-fold higher than the group treated with Mel/G(+NIR). Mel/G/DH(+NIR) treatment remodeled the immune microenvironment of distant tumors, increasing cytotoxic T cells and decreasing Treg cells. Taken together, the results of this study suggest the potential of Mel/G/DH as a platform for modulating tumor immune microenvironment aimed at preventing the recurrence of distant tumors.
Challenges and Perspectives for Therapeutic Targeting of Myeloproliferative Neoplasms
Authors: Sime Brkic, Sara C. Meyer
Journal: HemaSphere (2020)

Myeloproliferative neoplasms (MPNs) are hematopoietic stem cell disorders with dysregulated myeloid blood cell production and propensity for transformation to acute myeloid leukemia, thrombosis, and bleeding. Acquired mutations in
Epidemiology of brainstem high-grade gliomas in children and adolescents in the United States, 2000-2017
Authors: Nirav Patil, Michael E Kelly, Debra Nana Yeboa, Robin A Buerki, Gino Cioffi, Sweta Balaji, Quinn T Ostrom, Carol Kruchko, Jill S Barnholtz-Sloan
Journal: Neuro-Oncology (2020)

Abstract Background Limited population-based data exist for the brainstem gliomas for children ages ≤19 years, which includes high-grade aggressively growing tumors such as diffuse intrinsic pontine glioma (DIPG). We examined the overall incidence and survival patterns in children with brainstem high-grade glioma (HGG) by age, sex, and race and ethnicity. Methods We used data from Central Brain Tumor Registry of the United States (CBTRUS), obtained through data use agreements with the Centers for Disease Control (CDC) and the National Cancer Institute (NCI) from 2000 to 2017, and survival data from the CDCs National Program of Cancer Registries (NPCR), from 2001 to 2016 for malignant brainstem HGG for ages ≤19 years (per WHO ICD-O-3 codes). HGG was determined by established histologic and/or imaging criteria. Age-adjusted incidence rates and survival data were used to assess differences overall and by age, sex race, and ethnicity. Results The incidence of brainstem HGG was higher among the female and Non-Hispanic population. Majority (69.8%) of these tumors were diagnosed radiographically. Incidence was higher in children aged 1-9 years compared to older children. Whites had a higher incidence compared to Blacks. However, the risk of death was higher among Blacks and Other race compared to Whites. There was no difference in survival by sex. Conclusions We report the most comprehensive incidence and survival data on these lethal brainstem HGGs. Incidence and survival among patients with brainstem HGGs differed significantly by race, ethnicity, age-groups, and grade.