tbuckley/cabot-search huggingface dataset:
Bioresponsive immune-booster-based prodrug nanogel for cancer immunotherapy
Authors: Xianbin Ma, Shaochen Yang, Tian Zhang, Shuo Wang, Qichao Yang, Yao Xiao, Xiaoxiao Shi, Peng Xue, Yuejun Kang, Gang Liu, Zhi-Jun Sun, Zhigang Xu
Journal: Acta Pharmaceutica Sinica B (2021)

The combination of chemotherapy and immunotherapy motivates a potent immune system by triggering immunogenic cell death (ICD), showing great potential in inhibiting tumor growth and improving the immunosuppressive tumor microenvironment (ITM). However, the therapeutic effectiveness has been restricted by inferior drug bioavailability. Herein, we reported a universal bioresponsive doxorubicin (DOX)-based nanogel to achieve tumor-specific co-delivery of drugs. DOX-based mannose nanogels (DM NGs) was designed and choosed as an example to elucidate the mechanism of combined chemo-immunotherapy. As expected, the DM NGs exhibited prominent micellar stability, selective drug release and prolonged survival time, benefited from the enhanced tumor permeability and prolonged blood circulation. We discovered that the DOX delivered by DM NGs could induce powerful anti-tumor immune response facilitated by promoting ICD. Meanwhile, the released mannose from DM NGs was proved as a powerful and synergetic treatment for breast cancer in vitro and in vivo, via damaging the glucose metabolism in glycolysis and the tricarboxylic acid cycle. Overall, the regulation of tumor microenvironment with DOX-based nanogel is expected to be an effectual candidate strategy to overcome the current limitations of ICD-based immunotherapy, offering a paradigm for the exploitation of immunomodulatory nanomedicines.
POS1391 MEASURING SUBCLINICAL INFLAMMATION IN HAND AND FOREFOOT IN PATIENTS WITH ARTHRALGIA USING 1.5T OR 3.0T MRI: DOES FIELD STRENGTH MATTER?
Authors: D. Krijbolder, M. Verstappen, F. Wouters, L. R. Lard, P. D. De Buck, J. Veris-van Dieren, M. Reijnierse, H. Bloem, A. Van der Helm - van Mil
Journal: Annals of the Rheumatic Diseases (2021)

Background: Magnetic resonance imaging (MRI) of small joints sensitively detects inflammation. MRI-detected subclinical inflammation, and tenosynovitis in particular, has been shown predictive for RA development in patients with arthralgia. These scientific data are mostly acquired on 1.0T-1.5T MRI scanners. However, 3.0T MRI is nowadays increasingly used in practice. Evidence on the comparability of these field strengths is scarce and it has never been studied in arthralgia where subclinical inflammation is subtle. Moreover, comparisons never included tenosynovitis, which is, of all imaging features, the strongest predictor for progression to RA. Objectives: To determine if there is a difference between 1.5T and 3.0T MRI in detecting subclinical inflammation in arthralgia patients. Methods: 2968 locations (joints, bones or tendon sheaths) in hands and forefeet of 28 arthralgia patients were imaged on both 1.5T and 3.0T MRI. Two independent readers scored for erosions, osteitis, synovitis (according to RAMRIS) and tenosynovitis (as described by Haavaardsholm et al.). Scores were also summed as total inflammation (osteitis, synovitis and tenosynovitis) and total RAMRIS (erosions, osteitis, synovitis and tenosynovitis) scores. Interreader reliability (comparing both readers) and field strength agreement (comparing 1.5T and 3.0T) was assessed with interclass correlation coefficients (ICCs). Next, field strength agreement was assessed after dichotomization into presence or absence of inflammation. Analyses were performed on patient- and location-level. Results: ICCs between readers were excellent (&gt;0.90). Comparing 1.5 and 3.0T revealed excellent ICCs of 0.90 (95% confidence interval 0.78-0.95) for the total inflammation score and 0.90 (0.78-0.95) for the total RAMRIS score. ICCs for individual inflammation features were: tenosynovitis: 0.87 (0.74-0.94), synovitis 0.65 (0.24-0.84) and osteitis 0.96 (0.91-0.98). The field strength agreement on dichotomized scores was 83% for the total inflammation score and 89% for the total RAMRIS score. Of the individual features, agreement for tenosynovitis was the highest (89%). Analyses on location- level showed similar results. Conclusion: Agreement of subclinical inflammation scores on 1.5T and 3.0T were good to excellent, in particular for tenosynovitis. This suggests that scientific evidence on predictive power of MRI in arthralgia patients, obtained on 1.5T, can be generalized to 3.0T when this field strength would be used for diagnostic purposes in daily practice. Disclosure of Interests: None declared
POS0573 IMPACT OF JOINT DESTRUCTION IN THE HANDS, THE WRISTS AND THE ANKLES ON THE ULTRASOUND ASSESSMENT AND THE FUNCTIONAL OUTCOMES IN RHEUMATOID ARTHRITIS IN REMISSION
Authors: R. Fakhfakh, N. El Amri, K. Baccouche, H. Zeglaoui, E. Bouajina
Journal: Annals of the Rheumatic Diseases (2021)

Background: Joint destruction is a strong predictive factor for residual synovitis among rheumatoid arthritis (RA) patients in clinical remission. Both of them were associated with functional impairment. Objectives: To assess the ultrasound findings and functional outcomes of RA patients in remission according to the site of joint destruction. Methods: A Cross-sectional study including RA patients in remission DAS28 ESR≤ 2.6 for at least 6 months. A B-mode and power doppler (PD) ultrasound of 42 joints was performed. Synovitis was defined and scored using the combined OMERACT-PDUS (gray scale and power doppler (PD)) scoring system graded from 0 to 3. The health assessment questionnaire (HAQ) and the radiological Sharp score of the wrists, hands and feet were calculated. Results: Thirty-seven patients were included. The sex ratio was 0.37 and the mean age was 54.2 years ± 12.7. The mean disease duration was 8.1 years±5.1. The mean remission duration was 36.5 months ± 32.7. The mean DAS28vs was 2.1 ± 0.5. Rheumatoid factor and anti-citrullinated peptide antibodies were found in 62% and 75% of patients, respectively. The mean HAQ was 0.35 ± 0.38. Bone erosion was found in 81% of patients. In patients with hands and feet erosions (54%), synovitis was found in 90% of cases associated with PD in 70% of cases. The mean total score of synovitis was 7.8 ± 5.4. The mean HAQ was 0.37 ± 0.44. In patients with only erosions in the hands or wrists (18.9%), synovitis was found in 100% of cases associated with PD in 57% of cases. The mean total score of synovitis was 4.5±4.7. The mean HAQ was 0.48 ± 0.34. In patients with only feet erosions (8.1%), synovitis was found in 100% of cases associated with PD in 66.7% of cases. The mean total score of synovitis was 4.6±3.5. The mean HAQ was 0.31 ± 0.26. RA was not erosive in 18.9% of patients. In these patients, synovitis was found in 100% of cases associated with PD in 28.6% of cases. The mean total score of synovitis was 5.6±4.3. The mean HAQ was 0.21 ± 0.23. There is no significant difference between these groups(p&gt;0.05). Conclusion: In RA in remission, PD synovitis and functional incapacity were less frequent in the absence of erosion. PD synovitis was more frequently found in patients with erosions, especially, in the feet. The HAQ was higher in patients with hands erosions. References: [1]Hamamoto Y, Ito H, Furu M, Hashimoto M, Fujii T, Ishikawa M, et al. Serological and Progression Differences of Joint Destruction in the Wrist and the Feet in Rheumatoid Arthritis - A Cross-Sectional Cohort Study. PLoS One. 2015;10(8):e0136611. Disclosure of Interests: None declared
68Ga-DOTATATE and 68Ga-NODAGA-JR11 PET/CT Images in a Patient With Gastric Neuroendocrine Tumor
Authors: Zefang Lin, Rong Lin, Jiaying Zhang, Shaobo Yao, Weibing Miao
Journal: Clinical Nuclear Medicine (2021)

Abstract A 52-year-old man with newly diagnosed gastric neuroendocrine tumor (NET) underwent 68 Ga-NODAGA-JR11 and 68 Ga-DOTATATE imaging. 68 Ga-DOTATATE PET/CT showed no 68 Ga-DOTATATE uptake in the lesion, where 68 Ga-NODAGA-JR11 showed intense uptake. The patient subsequently received endoscopic submucosal dissection and en bloc resection of the lesion, which was pathologically confirmed as gastric NET (G2). The positive findings of 68 Ga-NODAGA-JR11 in the current case highlighted that 68 Ga-NODAGA-JR11 PET/CT may be a promising molecular imaging technique for the detection of NETs with high sensitivity.
Liquid Copolymers as Biodegradable Surgical Sealant
Authors: Neta Shimony, Alona Shagan, Bat‐hen Eylon, Abraham Nyska, Adi Gross, Boaz Mizrahi
Journal: Advanced Healthcare Materials (2021)

Abstract Surgical sealants are widely used to prevent seepage of fluids and liquids, promote hemostasis, and close incisions. Despite the remarkable progress the field of biomaterials has undergone, the clinical uses of surgical sealants are limited because of their short persistence time in vivo, toxicity, and high production costs. Here, the development of two complementary neat (solvent‐free) prepolymers, PEG 4 ‐PLGA‐NHS and PEG 4 ‐NH 2 , that harden upon mixing to yield an elastic biodegradable sealant is presented. The mechanical and rheological properties and cross‐linking rate can be controlled by varying the ratio between the two prepolymers. The tested sealants show a longer persistence time compared with fibrin glue, minimal cytotoxicity in vitro, and excellent biocompatibility in vivo. The neat, multiarmed approach demonstrated here improves the mechanical and biocompatibility properties and provides a promising tissue sealant solution for wound closure in future surgical procedures.
POS1138 SERUM URIC ACID-TO-CREATININE RATIO: A POTENTIAL MARKER FOR GOUT
Authors: Z. Huang, T. LI
Journal: Annals of the Rheumatic Diseases (2021)

Background: Serum uric acid-to-creatinine ratio (SUA/Cr) is a useful index of renal function-normalized serum uric acid (SUA), which reflects endogenous SUA levels more precisely than SUA. SUA/Cr relates to disease activity and prognosis of several metabolic disorders, like metabolic syndrome, non-alcoholic fatty liver disease, and diabetes mellitus [1]. Besides, the urine uric acid-to-creatinine ratio is valuable for the assessment of gout [2]. However, no study focuses on the relationship between SUA/Cr and gout. Objectives: We aimed to investigate the relationship between SUA/Cr and the features of demography, manifestations, laboratory tests, and urate-lowering therapies (ULTs) in gout patients. Methods: This cross-sectional study was performed from December 2015 to February 2020. Medical records of gout patients who were regularly undergone follow-up were evaluated. Characteristics of gout patients, included age, gender, the duration of gout, body mass index (BMI), tophus, complications, the number of flares, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR), were recorded. Complications were defined as hypertension, coronary artery diseases, diabetes, strokes, and/or metabolic diseases. Information about ULT was obtained as well. The Spearman correlation analysis was used to assess the relationship between continuous variables. The Mann-Whiney U test or Kruskal-Wallis test was employed to compare the differences of SUA/Cr between genders, ULTs, and whether patients had tophus or complications. A P&lt;0.05 was considered as statistically significant. Results: (1) Of 627 gout patients who were involved, 608 (96.97%) were male. Their median (range) of age and the duration of gout were 30.00 (51.00) years and 5.00 (30.00) years, respectively. (2) SUA/Cr negatively correlated with age (r=-0.71, P&lt;0.05). SUA/Cr was similar between genders. (3) SUA/Cr positively correlated with BMI (r=0.14, P&lt;0.05), while the coefficient correlation for the duration of gout and the number of flares did not reach statistically significant (P&gt;0.05). SUA/Cr was significantly higher in patients with complications than the others [5.56 (9.26) vs. 4.16 (8.34), P&lt;0.05], but whether patients with tophus or not shared similar SUA/Cr. (4) CRP and ESR did not associate with SUA/Cr (P&gt;0.05). (5) Patients with combination therapy with xanthine oxidase inhibitor and uricosuric agent had a lower SUA/Cr compared with those who used ULTs monotherapy [3.44 (7.10) vs. 4.53 (7.91), P&lt;0.05]. Conclusion: SUA/Cr relates to some features of gout, so it may be a potential marker for its assessment. References: [1]Medicine (Baltimore) 2020;99(17):e19959. [2]J Korean Med Sci 2020;35(13):e95. Disclosure of Interests: None declared.
Regulation of RNA polymerase II activity is essential for terminal erythroid maturation
Authors: Zachary C. Murphy, Kristin Murphy, Jacquelyn Myers, Michael Getman, Tyler Couch, Vincent P. Schulz, Kimberly Lezon-Geyda, Cal Palumbo, Hongxia Yan, Narla Mohandas, Patrick G. Gallagher, Laurie A. Steiner
Journal: Blood (2021)
Publisher Correction: Prisons as ecological drivers of fitness-compensated multidrug-resistant Mycobacterium tuberculosis
Authors: Sebastian M. Gygli, Chloé Loiseau, Levan Jugheli, Natia Adamia, Andrej Trauner, Miriam Reinhard, Amanda Ross, Sonia Borrell, Rusudan Aspindzelashvili, Nino Maghradze, Klaus Reither, Christian Beisel, Nestani Tukvadze, Zaza Avaliani, Sebastien Gagneux
Journal: Nature Medicine (2021)
Hemophagocytic lymphohistiocytosis after COVID-19 vaccination
Authors: Liang V. Tang, Yu Hu
Journal: Journal of Hematology & Oncology (2021)

Abstract Cases of thrombotic thrombocytopenia induced by coronavirus disease 2019 (COVID-19) vaccines have been reported recently. Herein, we describe the first case of another critical disorder, hemophagocytic lymphohistiocytosis (HLH), in a healthy individual after COVID-19 vaccination. A 43-year-old Chinese farmer developed malaise, vomiting, and persistent high fever (up to 39.7 °C) shortly after receiving the first dose of the inactivated SARS-CoV-2 vaccine. The initial evaluation showed pancytopenia (neutrophil count, 0.70 × 10 9 /L; hemoglobin, 113 g/L; platelet, 27 × 10 9 /L), elevated triglyceride (2.43 mmol/L), and decreased fibrinogen (1.41 g/L). Further tests showed high serum ferritin levels (8140.4 μg/L), low NK cell cytotoxicity (50.13%–60.83%), and positive tests for Epstein–Barr virus (EBV) DNA. Hemophagocytosis was observed in the bone marrow. Therefore, HLH was confirmed, and dexamethasone acetate (10 mg/day) was immediately prescribed without etoposide. Signs and abnormal laboratory results resolved gradually, and the patient was discharged. HLH is a life-threatening hyperinflammatory syndrome caused by aberrantly activated macrophages and cytotoxic T cells, which may rapidly progress to terminal multiple organ failure. In this case, HLH was induced by the COVID-19 vaccination immuno-stimulation on a chronic EBV infection background. This report indicates that it is crucial to exclude the presence of active EBV infection or other common viruses before COVID-19 vaccination.
POS0098 THE INFLUENCE OF THE ACTIVITY OF RHEUMATOID ARTHRITIS TO INFECTIOUS AND WOUND COMPLICATIONS AFTER TOTAL HIP AND KNEE ARTHROPLASTY
Authors: A. Khramov, M. Makarov, S. Makarov, S. Maglevaniy, E. Naryshkin, A. Dubinin
Journal: Annals of the Rheumatic Diseases (2021)

Background: Surgical treatment of patients with rheumatoid arthritis (RA) is associated with an increased risk of complications. This is due to the presence of inflammation, many variants of the disease, reduced physical activity, severity of functional disorders, prolonged therapy with glucocorticoids, disease-modifying antirheumatic drugs (DMARDs) and biological DMARDs, osteoporosis, as well as activity of the underlying disease. Objectives: to conduct a comparative analysis of the influence of RA activity levels on infectious complications (periprosthetic infection) and wound complications (poor healing, divergence, necrosis of the wound edges) after hip and knee arthroplasty in RA patients. Methods: 1113 arthroplasties were analyzed in patients with RA, which were performed between 2002 and 2019. Of these, 649 total knee arthroplasties and 464 total hip arthroplasties were performed. Results: Infectious complications after total hip and knee arthroplasty did not occur at 0 grade of disease activity (remission). At the I grade of activity, periprosthetic infections were detected with a frequency of 0.31%, at the II grade – 0.89%, and at the III level in 3.06% of cases. Complications from the operative wound occurred in 0.91% of cases with I grade of activity, at II grade with a frequency of 5.68%, and at III – 6.98%. There were no cases of complications from the wound in patients with remission of RA. Statistical analysis of the obtained data revealed a significantly higher number of complications in the group of RA patients (p&lt;0.005). During analyzing each type of complication, significant differences were also obtained (p&lt;0.005). Conclusion: Risk of periprosthetic infection and complications from the wound is several times higher in patients with a high grade of RA activity. This means that performing arthroplasty, as well as other operations, in patients with high RA activity correlates to a high risk of complications. Disclosure of Interests: None declared
Gut and vaginal microbiomes on steroids: implications for women’s health
Authors: Madeline E. Graham, William G. Herbert, Stephanie D. Song, Harshini N. Raman, Jade E. Zhu, Paulina E. Gonzalez, Marina R.S. Walther-António, Marc J. Tetel
Journal: Trends in Endocrinology and Metabolism (2021)
Abstract 10438: A 20-Year Propensity Matched Analysis Comparing Aortic Cross Clamp Fibrillation With Blood Cardioplegia in More Than 6500 Coronary Patients
Authors: Priyadharshanan Ariyaratnam, Mahmoud Loubani
Journal: Circulation (2018)

Introduction: Aortic Cross Clamp Fibrillation (XCF) is not as widely used a method of myocardial protection as compared to cardioplegic arrest of the heart in performing coronary artery bypass graf...
Abstract 15342: Increased Liver Stiffness Evaluated by Virtual Touch Quantification Method Can Predict Poor Clinical Outcomes in Patients With Heart Failure
Authors: Kazunori Omote, Naoya Asakawa, Yoshiya Kato, Yusuke Tokuda, Masanao Naya, Yokoshiki Hisashi
Journal: Circulation (2017)

Background: Heart failure (HF) is often associated with liver congestion, which has been proposed to increase liver stiffness. Tissue elastography evaluated by virtual touch quantification method (...
An intrinsically bioactive hydrogel with on-demand drug release behaviors for diabetic wound healing
Authors: Bin Hu, Mingzhu Gao, Kofi Oti Boakye-Yiadom, William Ho, Wei Yu, Xiaoyang Xu, Xue-Qing Zhang
Journal: Bioactive Materials (2021)

Prolonged, intense inflammation and excessive oxidative stress hinder diabetic wounds from healing normally, leading to disorders downstream including the postponement of re-epithelialization and extracellular matrix (ECM) formation. Herein, we report a hyaluronic acid (HA) and chitosan based hydrogel (OHA-CMC) with inherent antibacterial and hemostatic activities fabricated via Schiff base reaction. By encapsulating nanotechnologically-modified curcumin (CNP) and epidermal growth factor (EGF) into the hydrogel, OHA-CMC/CNP/EGF exhibited extraordinary antioxidant, anti-inflammatory, and migration-promoting effects in vitro. Meanwhile, OHA-CMC/CNP/EGF presented on-demand drug release in synchrony with the phases of the wound healing process. Specifically, curcumin was rapidly and constantly released to alleviate inflammation and oxidative stress in the early phase of wound healing, while a more gradual and sustained release of EGF supported late proliferation and ECM remodeling. In a diabetic full-thickness skin defect model, OHA-CMC/CNP/EGF dramatically improved wound healing with ideal re-epithelialization, granulation tissue formation, and skin appendage regeneration, highlighting the enormous therapeutic potential this biomaterial holds as a diabetic wound dressing.
Growth inhibitory and chemosensitizing effects of chemotherapeutic agents by ZD6474 (vandetanib) in human gastric cancer cells
Authors: Kun-Huei Yeh, Hsun-Fang Fan, Ying-Chun Shen, Joeu-Pei Wan, Chin-Lun Huang, Ann-Lii Cheng
Journal: Cancer Research (2008)

1437  There is evidence that links cellgrowth and angiogenesis in gastric cancer (GC). One promising treatment approach in GC involvestherapeutic agents that inhibit cell growth and angiogenesis. Epidermal growth factor receptor (EGFR) signaling pathway is also deregulated in GC. ZD6474 (vandetanib, Astra Zeneca) is a small molecule tyrosine kinase inhibitor (TKI) that specifically inhibits the VEGFR (vascular endothelial growth factor receptor) and EGFR. In the TMK-1 xenograft model, McCarty MF et al reported that ZD6474 could reduce tumor cell proliferation, increase tumor cell apoptosis, and decrease microvessel density (Mol Cancer Ther 2004; 3: 1041).  A panel of human gastric cancer ATCC cell lines was used in this study, including KATO-III, SNU-1, AGS, and N87, etc. Both EGFR and VEGFR-2 isoform were detected in AGS, KATO-III, SNU-1, and N87 by western blot analysis (HUVEC cells were used as a positive control for VEGFR-2 western blotting). EGFR and VEGFR-2 isoform most abundantly expressed in SNU-1 and KATO-III cells. Using MTT colorimetric assay, growth inhibitory effects by ZD6474 was found in GC cells, with an IC50 of 2.5±0.3, 5.1±0.4, and 8.2±0.6 μM in KATO-III, SNU-1, and AGS cells, respectively. Chemosensitizing effects of ZD6474 (vandetanib) for chemotherapeutic agents (gemcitabine, oxaliplatin, or 5-fluorouracil, etc.) were explored in SNU-1 cells, which were highly VEGFR-2 and EGFR expressing, as a model. Using MTT assay and median effect analysis with a fixed ratio (1:1000) of two-drug combination, gemcitabine and ZD6474 showed synergistic growth inhibition with a combination index (CI)
Advances in Aortic Valve Repair, Particularly Bicuspid Valves—Reply
Authors: Ulrich Schneider, Jakob Schöpe, Hans-Joachim Schäfers
Journal: JAMA Cardiology (2021)

In Reply We highly appreciate the interest of Svensson and colleagues in our recent study1 on bicuspid aortic valve (BAV) repair, and we congratulate them on their own achievements in this field of cardiac surgery.