tbuckley/cabot-search huggingface dataset:
The influence of circulating catecholamines and prostaglandins on canine renal hemodynamics during hemorrhage.
Authors: W LHenrich, W APettinger, R ECronin
Journal: Circulation Research (1981)

The relationship between circulating catecholamines and prostaglandins and the independent contribution of circulating catecholamines to renal vasoconstriction during hemorrhage is unknown. The renal hemodynamic effects of a 30% decrease in blood pressure by hemorrhage were therefore studied in three groups of anesthetized dogs which had undergone prior bilateral renal denervation. A constant unilateral infusion of the catecholamine antagonist phenoxybenzamine (POB, 0.2 micrograms/kg per min) into the renal artery during hemorrhage was also performed. In the control (C) dogs (n = 6), hemorrhage was not associated with significant changes in glomerular filtration rate (GFR) or renal blood flow (RBF) in either POB-infused and denervated or noninfused, denervated kidneys. In the second group of dogs (n = 8), pretreated with the prostaglandin inhibitor indomethacin (IN, 10 mg/kg, iv), POB-infused and denervated kidneys had a significantly higher GFR (30 vs. 23 ml/min, P less than 0.05) and RBF (180 vs. 130 ml...
Comparison of Chronic Graft-Versus-Host Disease Severity and Functional Status after Cord Blood, Haploidentical Related and 1-Allele Mismatched Unrelated Donor Hematopoietic Cell Transplantation
Authors: Giancarlo Fatobene, Barry E. Storer, Rachel B. Salit, Stephanie J. Lee, Paul J. Martin, Guang-Shing Cheng, Colleen Delaney, Frederick R. Appelbaum, Brenda M. Sandmaier, Filippo Milano, Mary E. Flowers
Journal: Blood (2017)
Endogenous fibrinolytic system in chronic large-vessel thromboembolic pulmonary hypertension.
Authors: M AOlman, J JMarsh, I MLang, K MMoser, B RBinder, R RSchleef
Journal: Circulation (1992)

BACKGROUNDChronic thromboembolic pulmonary hypertension (CTEPH) is a disorder characterized by pulmonary arterial hypertension as a consequence of organized thrombotic material in the central pulmonary arteries. Incomplete resolution of acute pulmonary emboli is believed to be pathogenically important; however, the mechanism for poor thrombus dissolution remains to be explained. We undertook this study to assess the major determinants of plasma fibrinolysis in patients with CTEPH (n = 32).METHODS AND RESULTSImmunological and functional levels of tissue-type plasminogen activator (t-PA) and type 1 plasminogen activator inhibitor (PAI-1) were quantified in platelet-poor plasma (PPP) from patients with CTEPH as well as age-matched controls. Although basal PPP t-PA antigen levels (CTEPH mean, 29.5 ng/ml; control mean, 2.7 ng/ml) and PAI-1 antigen levels (CTEPH mean, 55.8 ng/ml; control mean, 21.0 ng/ml) were higher in the CTEPH group, no between-group differences were detected in the enzymatic activities of t...
Prognosis of myocardial infarctions involving more than 40% of the left ventricle after acute reperfusion therapy.
Authors: B DMcCallister, T FChristian, B JGersh, R JGibbons
Journal: Circulation (1993)

BACKGROUNDPrior studies based on autopsy data suggest that infarction of more than 40% of the left ventricle necessitates cardiogenic shock and death.METHODS AND RESULTSTechnetium-99m Sestamibi tomography was used prospectively to measure infarct size at discharge in 166 patients with acute myocardial infarction. Patients with previous myocardial infarction or revascularization were excluded from the trial. Sixteen patients were identified with final infarct sizes > 40% of the left ventricle despite acute reperfusion therapy. These 16 patients (13 men) had a mean age of 63 +/- 10 years; 44% had a previous history of angina. Ten patients had emergent coronary angioplasty only (mean time to percutaneous transluminal coronary angioplasty [PTCA], 6.0 +/- 3.0 hours); 6 had thrombolysis (mean time to tissue plasminogen activator, 4.0 +/- 1.5 hours), of which 2 had rescue PTCA (5 and 3 hours from onset of pain). Of 15 patients who had angiograms after therapy, 15 had open infarct-related arteries. The left anter...
Reentrant and nonreentrant mechanisms contribute to arrhythmogenesis during early myocardial ischemia: results using three-dimensional mapping.
Authors: S MPogwizd, P BCorr
Journal: Circulation Research (1987)

The present study assessed the mechanisms responsible for the initiation and maintenance of premature ventricular complexes (PVCs) and ventricular tachycardia (VT) during early ischemia using a unique computerized mapping system capable of recording simultaneously from 232 individual intramural sites. In the chloralose-anesthetized cat, during normal sinus rhythm prior to ischemia, ventricular activation was rapid with a total activation time of 25 +/- 2 msec. Five minutes after occlusion of the left anterior descending (LAD) coronary artery, activation was delayed during sinus rhythm (64 +/- 6 msec) (p less than 0.001 vs. control) and was characterized by slow conduction in the same plane and block in both the same plane and in the endocardial-to-epicardial direction. In 76% of cases (16 of 21), initiation of single PVCs and the first beat of VT occurred through intramural reentry. In all but one case, initiation occurred in the subendocardium, adjacent to the site of delayed subendocardial and midmyocar...
Dopamine attenuates the contractile response to angiotensin II in isolated rat glomeruli and cultured mesangial cells.
Authors: RBarnett, P CSinghal, L AScharschmidt, DSchlondorff
Journal: Circulation Research (1986)

Recent evidence suggests that dopamine may alter kidney function by actions not only in the renal vasculature but also at the glomerular-mesangial level. We studied this phenomenon by examining the ability of dopamine to antagonize the contractile properties of angiotensin II in isolated rat glomeruli and cultured mesangial cells. In isolated rat glomeruli angiotensin II caused a decrease in the planar surface area, indicating glomerular contraction, an effect that was abolished by coincubation with dopamine. Angiotensin II also mediated shape changes in cultured mesangial cells, which resulted in a decline in their planar areas. Simultaneous addition of dopamine prevented these decreases in cell size. In mesangial cells grown on a flexible silicone rubber support, angiotensin II addition enhanced wrinkling of the mobile surface. This indicated that the angiotensin-II-induced decrease in cell size observed in cells grown on conventional substrata represented contraction. Conversely, dopamine caused a rapi...
Initial Experience with Single-port Robotic-assisted Kidney Transplantation and Autotransplantation
Authors: Jihad Kaouk, Mohamed Eltemamy, Alireza Aminsharifi, Zeyad Schwen, Clark Wilson, Mahmoud Abou Zeinab, Juan Garisto, Louis Lenfant, Alvin Wee
Journal: European Urology (2021)
Serial changes in left ventricular relaxation and chamber stiffness after large myocardial infarction in rats.
Authors: T ERaya, R GGay, LLancaster, MAguirre, CMoffett, SGoldman
Journal: Circulation (1988)

To determine the time course of changes in left ventricular diastolic properties after a large myocardial infarction, we serially measured left ventricular relaxation, chamber stiffness, and the ratio of left ventricular cavity to wall volume (V/VW) after coronary artery ligation in rats. Left ventricular relaxation was measured during the occlusion and then both relaxation and chamber stiffness were measured at 3 hr, 24 hr, and 3, 5, and more than 22 days after infarction. Left ventricular pressures and left ventricular dP/dt were recorded with micromanometer-tipped catheters. Left ventricular relaxation was measured by computer digitization of the left ventricular pressure tracings and averaged over 100 to 150 cardiac cycles. Five chamber stiffness constants were calculated from pressure-volume curves that were obtained ex vivo. We found ventricular relaxation prolonged for the first hour after coronary occlusion; relaxation was maximally prolonged at 10 to 15 min after onset of occlusion. After 1 hr re...
What are the Most Frequent Complications of a Peg Procedure in Daily Practice? a Retrospective Analysis in a Tertiary Center
Authors: T Moga, I Ratiu, C Foncea, A Barbulescu, R Lupusoru, B Miutescu, R Cotrau, A Popescu, F Dan, D Jianu, M Simu, I Sporea
Journal: Endoscopy (2021)

Aims The aim of this study was to assess the most frequent complication of the PEG procedure and device-related complication and also to analyze the management framework of the patients undergoing this maneuver.
Myocardial monovalent cation transport during the quinidine-digoxin interaction in dogs.
Authors: N JWarner, J TBarnard, E BLeahey, T JHougen, J TBigger, T WSmith
Journal: Circulation Research (1984)

To study the relationship of the serum digoxin concentration to the digoxin effect on monovalent cation transport during the quinidine-digoxin interaction, we used radiolabeled rubidium to measure monovalent cation active transport in myocardial biopsy samples from dogs. In a preliminary study, we showed that quinidine did not affect rubidium uptake by myocardial samples from intact dogs. Then, we studied four groups, each consisting of 13 dogs, which received either saline, low dose digoxin, high dose digoxin, or low dose digoxin plus quinidine treatment. In these groups of dogs, the following steady state serum digoxin concentrations were achieved: saline-treated, 0 ng/ml; low dose digoxin, 1.2 +/- 0.2 ng/ml (mean +/- SD); high dose digoxin, 2.4 +/- 0.4 ng/ml; and low-dose digoxin plus quinidine treated, 2.3 +/- 1.1 ng/ml. Compared to control values, rubidium uptake was decreased by 17% in dogs treated with low dose digoxin (P less than 0.05) and by 38% in dogs treated with high dose digoxin (P less tha...
Attributable risk, population attributable risk, and population attributable fraction of death associated with hypertension in a biracial population.
Authors: D CDeubner, H ATyroler, J CCassel, C GHames, CBecker
Journal: Circulation (1975)

In 1961, blood pressure was measured in the 40-69-year-old segment of the population of Evans County, Georgia. Mortality was monitored for up to ten years. The relationship found between hypertension and mortality is characterized in this report by four parameters: attributable risk, prevalence, population attributable risk, and population attributable fraction. Attributable risk of death, a measure of the over-all impact of hypertension on those in each race-sex group with hypertension, is high in white males, black males, and black females, and is lowest in white females. Population attributable risk, a measure of the impact of hypertension on each entire race-sex group, is highest in black males and females due to the high prevalence of hypertension in blacks. It is somewhat lower in white males and lowest in white females. The fraction of all deaths attributable to hypertension (population attributable fraction) is highest in black females and lower in the other three groups. The population attributab...
The Cold-Shock Protein Ybx1 Is Required for Development and Maintenance of Acute Myeloid Leukemia (AML) in Vitro and In Vivo
Authors: Florian Perner, Ashok K. Jayavelu, Tina Maria Schnoeder, Nomusa Mashamba, Juliane Mohr, Maximilian Hartmann, Kristin Odenwald, Nikolas Schroeder, Sabine Brandt, Peter Mertens, Lars Bullinger, Florian H. Heidel
Journal: Blood (2017)
Variables predictive of successful medical therapy in patients with unstable angina: selection by multivariate analysis from clinical, electrocardiographic, and angiographic evaluations.
Authors: POuyang, J ABrinker, E DMellits, M LWeisfeldt, GGerstenblith
Journal: Circulation (1984)

Although unstable angina can be initially controlled with medical therapy in most patients, there is a high incidence of subsequent death, myocardial infarction, or need for coronary bypass surgery to control symptoms. Identification at the time of presentation of the patient likely to do poorly on continued medical therapy would be useful in advising consideration of surgical therapy. Since coronary arterial spasm may have a significant role in the pathophysiology of unstable angina in some patients, the recently developed calcium channel antagonists may therefore be of particular benefit in the medical therapy of unstable angina. One hundred thirty-eight patients were entered into a randomized double-blind study of the efficacy of adding nifedipine to conventional treatment of unstable angina (nitrates and beta-blockers) and were followed for 18 months. Of these patients, 104 underwent coronary arteriography. A multivariate Cox's hazard function analysis was applied to variables selected from the histor...
Response to the presidential address: APA enters the twenty-first century
Authors: David G. Borenstein
Journal: American Journal of Psychiatry (2000)

It is exhilarating to become the first APA President to serve in the twenty-first century. I am the 129th President elected but only the 127th President to assume office because two of our respected colleagues expired before taking office. I am not surprised, considering the stresses of APA elections. My odyssey from a small New Mexico city, where I was clearly a member of a minority, through military school, engineering school, medical school, residency, and psychoanalytic training to the leadership of the largest, most prestigious psychiatric organization in the world is beyond my wildest imagination. What an honor and an awesome responsibility! However, I am eager to meet the challenges that accompany this position, knowing that I have the support and assistance of my extremely talented colleagues on the Board of Trustees, the many other members who volunteer countless hours to our organization, and the dedicated, hard-working staff. The understanding, encouragement, and loving support of my spouse, Bonnie, for the past 33 years and our son Jay made it possible for me to be in this position today. We are very proud of Jay. Aside from being a great person, he is Vice President of Engineering in charge of technical development for an Internet start-up company. Our relatives, Skip and Dede Priest, and special friends like Dan Belin, a brilliant attorney, and my closest psychiatric colleagues from Los Angeles have been particularly helpful. I will focus on some of the actions planned for next year. Many of these initiatives began through the pioneering efforts of previous Presidents. Through our business and industry initiative, through legislation and through litigation, if necessary, we will lead the way in restoring our patients’ access to high-quality care in both the public and private sectors. Patients must be able to choose their doctors. Treating physicians must be able to make unfettered medical decisions for their patients. Peter Drucker tells us, “The best way to predict the future is to create it.” That is our aim. Reallocating $2.4 million toward high priorities and a new corporate structure in January 2001 will help us reach our goals.
A Rare Challenging Complication Of Intragastric Balloon: Gastric Outlet Obstruction
Authors: S Lamas, A Lopez-Mourelle, P Arguelles-Estrada, A Gejo, L Carballo-Folgoso, M Celada-Sendino, N Rodriguez-Ferreiro, V Beltran, C del Caño-Cerdan, A Nieto-Jara, A Suarez-Noya, M Fraile, P Florez-Diez
Journal: Endoscopy (2021)

A woman with obesity, previosly treated with POSE procedure, gets placed a intragastric ballon (Spatz3). 36 hours after, she comes to emergency room complainting epigastric pain and vomits. CT showed esophageal and gastric distention with antral balloon impaction. Urgent gastroscopy failed to reposition the balloon due to POSE-related anatomic alteration, so balloon retrieval was decided. Given the lack of specific endoscopic equipment for this purpose, we tried to deflate balloon with a sclerotherapy needle, being tecnically difficult because of its caliber (23G). An ultrasound-endoscopic biopsy needle (EchoTipProCore19G) was then used to deflate it and retraival was achieved with a snare.
Abstract 17033: Inflammation and Lipids Components: Insights From the VLDL Study
Authors: Abdulhamied Alfaddagh, Renato Quispe, Steven R Jones
Journal: Circulation (2020)

Background: Dyslipidemia and inflammation independently contribute to atherosclerosis. The associations between different lipid parameters and inflammatory markers is not fully understood. Hypothesis: LDL-C, triglycerides, and HDL-C do not predict inflammation equally. Methods: We analyzed data from 784,233 patients from the second harvest of the Very Large Database of Lipid study with lipids and hsCRP measured. The prevalence of having hsCRP≥2 mg/L was compared in 20 quantiles of non-HDL-C, LDL-C, HDL-C and triglycerides. Using linear regression, we estimated the correlations between hsCRP and lipids and to what degree individual lipid components explain the variation in hsCRP values. We then examined these association by sex and age (≥65 vs &lt;65 years) categories. Results: The median hsCRP of the population was 2.3 mg/L (IQR, 1.0-5.7). The proportion of patients with hsCRP≥2 mg/L progressively increased with higher non-HDL-C, LDL-C, triglycerides quintiles, but decreased with higher HDL-C quintiles. All lipid measures directly correlated with hsCRP value except HDL-C which was inversely correlated (P&lt;0.001 for all). LDL-C and non-HDL-C values explained very little of the variance seen in hsCRP (univariate R 2 = 0.5% and 0.1%, respectively). Triglyceride levels were the strongest predictor of hsCRP (standardized β, 0.21; P&lt;0.001) and explained 4.5% of variability in hsCRP values. HDL-C was the second best (albeit an inverse) predictor of hsCRP (standardized β, -0.19; P&lt;0.001) and explained 3.8% of its variance. Regardless LDL-C quantile, the prevalence of having hsCRP ≥2 mg/L was lower in those also have low triglyceride or high HDL-C levels (Figure). These associations were consistent by sex and age categories. Conclusion: Of major lipid and lipoprotein cholesterol fractions, triglycerides and HDL-C correlated most strongly and non-HDL-C and LDL-C contributed the least to hsCRP.
Comparison of early thallium-201 scintigraphy and gated blood pool imaging for predicting mortality in patients with acute myocardial infarction.
Authors: L CBecker, K JSilverman, B HBulkley, C HKallman, E DMellits, MWeisfeldt
Journal: Circulation (1983)

The extent of abnormality in early thallium-201 and gated cardiac blood pool scintigrams has been reported to be useful for predicting mortality in patients with acute myocardial infarction (AMI). To compare the two techniques, 91 patients admitted consecutively with evident or strongly suspected AMI underwent both imaging studies within 15 hours of the onset of symptoms. Patients with pulmonary edema or shock were excluded. AMI developed in 84% of patients, and 6-month mortality for the entire group was 16%. A thallium defect score of 7.0 or greater (corresponding to at least a moderate reduction of activity involving 40% of the left ventricular circumference) identified a subgroup of 14 patients with 64% 6-month mortality rate. Similarly, a left ventricular ejection fraction of 35% or less identified a high-risk subgroup of 10 patients with a 6-month mortality of 60%. Mortality in the remaining patients was 8% for thallium score less than 7 and 11% for ejection fraction greater than 35%. The mortality r...
Sinus node function and conduction system after complete repair of tetralogy of Fallot.
Authors: HNiederhauser, PSimonin, BFriedli
Journal: Circulation (1975)

Twenty-three children underwent electrophysiological studies during routine postoperative catheterization two months to five years after complete correction of tetralogy of Fallot. The aim of the study was to investigate the whole conduction system, including sinus node function, suing His bundle recordings and atrial pacing. H-V intervals were normal at rest and with pacing in twenty-two patients, including four patients with evidence of bifascicular block on the surface ECG. One patient with cardiomegaly and evidence of diffuse myocardial damage had a prolonged H-V interval but did not develop a block at this level during pacing A-H interval was slightly prolonged in four patients and normal in all others. The threshold of pacing-induced atrioventricular block ranged from 75 to 240/min and was somewhat age dependent (r = -0.55). Two patients fell below the 95% confidence limit of this regression and are considered abnormal. One returned to normal after intravenous injectionof atropine. Corrected sinus n...
Diagnostic Yield of EUS FNA in Digestive Tract Masses
Authors: N El Moutaoukil, A Taiymi, M Oualgouh, K Rais, FZ Baddi, A Bennani, A El Mekkaoui, G Kharrasse, A Zazour, W Khannoussi, MZ Ismaili
Journal: Endoscopy (2021)

Aims To evaluate the yield of ultrasound endoscopic guided FNA in the diagnosis of digestive tract masses.
Delineation of the distribution of beta-adrenergic receptor subtypes in canine myocardium.
Authors: S SMurphree, J ESaffitz
Journal: Circulation Research (1988)

beta 2-Receptors constitute only 10-30% of the total beta-adrenergic receptors in mammalian ventricular myocardium, but their precise tissue location cannot be determined easily by measuring physiological variables. To delineate the distribution of beta-receptor subtypes in myocytic and vascular components of the heart, we incubated transmural sections of canine left ventricle with [125Iodo]cyanopindolol and selected concentrations of the beta 1-selective antagonist betaxolol or the beta 2-selective antagonist ICI 118,551. Detailed competition binding data were best accounted for by a two-site model in which approximately 75% of total sites were beta 1- and 25% were beta 2-receptors. The relative proportions of beta-receptor subtypes in myocytic and vascular components were assessed autoradiographically by analyzing the density of binding sites in transmural sections incubated with radioligand and subtype-selective displacers. Betaxolol (10(-7) M) reduced the density of radioligand binding sites by 44% in...
Cardiac tamponade complicating proximal aortic dissection. Is pericardiocentesis harmful
Authors: E MIsselbacher, J ECigarroa, K AEagle
Journal: Circulation (1994)

BACKGROUNDCardiac tamponade frequently complicates acute proximal aortic dissection and is one of the most common causes of death from aortic dissection. Well-defined strategies for the management of acute aortic dissection now exist; however, little is known about how best to manage the hemopericardium that may complicate it.METHODS AND RESULTSUsing a computer-based review, we retrospectively identified 10 patients presenting to our hospital over a 13-year period who were diagnosed with both aortic dissection and cardiac tamponade. All 10 had proximal dissections. Three of the 10 presented as the sudden onset of fatal electromechanical dissociation, 6 presented with hypotension, and 1 was normotensive on presentation. Of the 7 hypotensive or normotensive patients diagnosed with cardiac tamponade, 4 underwent successful pericardiocentesis while awaiting surgery. At time intervals of 5 to 40 minutes after their pericardiocenteses, 3 of the 4 patients experienced sudden onset of electromechanical dissociati...