tbuckley/cabot-search huggingface dataset:
Transcriptomic Profiling Identifies a Risk Stratification Signature for Predicting Peritoneal Recurrence and Micrometastasis in Gastric Cancer
Authors: In-Seob Lee, Heonyi Lee, Hoon Hur, Mitsuro Kanda, Jeong-Hwan Yook, Byung-Sik Kim, Yanghee Woo, Yasuhiro Kodera, Kwangsoo Kim, Ajay Goel
Journal: Clinical Cancer Research (2021)

Abstract Purpose: Gastric cancer peritoneal carcinomatosis is fatal. Delay in detection of peritoneal metastases contributes to high mortality, highlighting the need to develop biomarkers that can help identify patients at high risk for peritoneal recurrence or metastasis. Experimental Design: We performed a systematic discovery and validation for the identification of peritoneal recurrence prediction and peritoneal metastasis detection biomarkers by analyzing expression profiling datasets from 249 patients with gastric cancer, followed by analysis of 426 patients from three cohorts for clinical validation. Results: Genome-wide expression profiling identified a 12-gene panel for robust prediction of peritoneal recurrence in patients with gastric cancer (AUC = 0.95), which was successfully validated in a second dataset (AUC = 0.86). Examination of 216 specimens from a training cohort allowed us to establish a six gene–based risk-prediction model [AUC = 0.72; 95% confidence interval (CI): 0.66–0.78], which was subsequently validated in an independent cohort of 111 patients with gastric cancer (AUC = 0.76; 95% CI: 0.67–0.83). In both cohorts, combining tumor morphology and depth of invasion further improved the predictive accuracy of the prediction model (AUC = 0.84). Thereafter, we evaluated the performance of the identical six-gene panel for its ability to detect peritoneal metastasis by analyzing 210 gastric cancer specimens (prior 111 patients plus additional 99 cases), which discriminated patients with and without peritoneal metastasis (AUC = 0.72). Finally, our biomarker panel was also remarkably effective for identifying peritoneal micrometastasis (AUC = 0.72), and its diagnostic accuracy was significantly enhanced when depth of invasion was included in the model (AUC = 0.85). Conclusions: Our novel transcriptomic signature for risk stratification and identification of high-risk patients with peritoneal carcinomatosis might serve as an important clinical decision making in patients with gastric cancer.
Viral Loads of SARS-CoV-2 in Young Children—Reply
Authors: Taylor Heald-Sargent, William J. Muller, Larry K. Kociolek
Journal: JAMA Pediatrics (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Endoscopic ultrasound-guided gallbladder drainage after real-time assessment of cystic duct exclusion following biliary placement of an uncovered metal
Authors: Giuseppe Vanella, Matteo Tacelli, Maria Chiara Petrone, Paolo Giorgio Arcidiacono
Journal: Endoscopy (2021)

An 80-year-old patient was admitted because of abdominal pain, vomiting, recent-onset diabetes, and weight loss. Computed tomography (CT) and endoscopic ultrasound (EUS) allowed diagnosis of a 5-cm adenocarcinoma of the pancreatic head, with liver metastasis and obstructive jaundice. Endoscopic retrograde cholangiopancreatography (ERCP) was performed with a 4-cm partially covered self-expanding metal stent (SEMS). Due to persistent discomfort and pain, ultrasonography was performed and showed gallbladder hydrops.
Assessment of Outpatient Dispensing of Products Proposed for Treatment or Prevention of COVID-19 by US Retail Pharmacies During the Pandemic
Authors: Andrew I. Geller, Maribeth C. Lovegrove, Jennifer N. Lind, S. Deblina Datta, Daniel S. Budnitz
Journal: JAMA Internal Medicine (2021)

This cross-sectional study examines changes in the outpatient retail dispensing frequency of proposed treatments for coronavirus disease 2019 after the March 13, 2020, declaration of a national emergency due to the pandemic.
Abstract 14784: Sleep Moderates the Association Between Arterial Stiffness and Blood Pressure Variability
Authors: Xiaoyue Liu, Guofen Yan, Linda Bullock, Debra Barksdale, Jeongok G Logan
Journal: Circulation (2020)

Introduction: Both arterial stiffness and short-term blood pressure variability (BPV) are important subclinical biomarkers of cardiovascular disease (CVD). Evidence is accumulating that poor sleep is associated with subclinical CVD. The purpose of our study was to investigate how sleep was related to arterial stiffness and BPV. We also explored if sleep changed the association between arterial stiffness and BPV. Methods: In this cross-sectional study, objective sleep characteristics were assessed by a wrist actigraphy over two days. Arterial stiffness was measured by carotid femoral pulse wave velocity (cfPWV). BPV was evaluated using an ambulatory blood pressure monitor over 24 hours and estimated by average real variability. Results: The sample included 87 healthy adults aged between 35 and 64 years. Sleep efficiency was an independent predictor of cfPWV and systolic BPV (SBPV), while wake after sleep onset (WASO) was an independent predictor of cfPWV, only. In addition, cfPWV showed a positive relationship with SBPV, and this relationship was moderated by sleep efficiency and WASO, respectively. The relationship between cfPWV and SBPV became stronger among individuals who had a level of sleep efficiency lower than 84% and who had WASO higher than 67 minutes, respectively. Conclusions: Our study showed that poor sleep not only had a direct link with arterial stiffness and BPV, but also moderated the relationship between these two subclinical CVD biomarkers. These findings implied that improving sleep quality could be a target intervention to promote cardiovascular health in clinical practice.
RISK-1: One-year Retrospective Study to Assess Cardiovascular Risk at the Onset of Type 2 Diabetes Mellitus in Slovenia
Authors: Iris Marolt, Jana Komel, Elena Kuzmina, Anja Babič, Renata Kopriva, Marjan Kristanc, Marta Simonič, Zorančo Trpkovski, Eva Zemljič
Journal: Metabolism (2021)
Molecular Mechanisms of Diaphragm Myopathy in Humans With Severe Heart Failure
Authors: Norman Mangner, Jens Garbade, Estelle Heyne, Marloes van den Berg, Ephraim B. Winzer, Jennifer Hommel, Marcus Sandri, Joanna Jozwiak-Nozdrzykowska, Anna L. Meyer, Sven Lehmann, Clara Schmitz, Edoardo Malfatti, Michael Schwarzer, Coen A.C. Ottenheijm, T. Scott Bowen, Axel Linke, Volker Adams
Journal: Circulation Research (2021)

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DiGeorge Syndrome and COVID-19 in Two Pediatric Patients
Authors: Eilaf Fallatah, Yatyng Chang, Jose Calderon, Vivian Hernandez- Trujillo
Journal: Journal of Allergy and Clinical Immunology (2021)

Immunocompromised patients, including those with primary immunodeficiency, may be expected to have more severe COVID-19 disease. However, the evidence is unclear as limited cases have been reported. Hispanic ethnicity and obesity also appear to confer risk of more severe disease in adults. Two pediatric patients with DiGeorge syndrome and COVID-19 are described. A 12-year-old female with DiGeorge syndrome with hypogammaglobulinemia on monthly immunoglobulin replacement and T cell lymphocytopenia, congenital heart disease, and VP shunt, presented to the ED with headache and an episode of emesis. Brain CT and shunt series were obtained to rule out shunt malfunction, both normal. Immediate family members were diagnosed with COVID-19 and our patient also tested PCR positive. She was treated with supportive care. Repeat COVID-19 PCR testing 3 weeks later was still positive, although asymptomatic. A 13-year-old Hispanic male with DiGeorge syndrome, obesity, and congenital heart disease with immediate family members diagnosed with COVID-19 also tested PCR positive. Three family members required hospital admission, one of which required ICU admission and remains on supplemental oxygen. He had history of normal T lymphocytes and low IgM. Despite a complex medical history, he remained asymptomatic. Both patients had history of normal mitogens. Pediatric patients with primary immunodeficiency, specifically those with DiGeorge syndrome, may not necessarily be at increased risk of severe COVID-19 disease. One Hispanic patient with obesity and congenital heart disease was asymptomatic. More cases are needed to better understand risk factors in pediatric patients with primary immunodeficiency and COVID-19.
Abstract 9742: Longitudinal Trajectories of Albuminuria in Young Adulthood and Myocardial Structure and Function in Later Life: The Cardia Study
Authors: Ravi B Patel, Laura A Colangelo, Jared P Reis, Joao A Lima, Sanjiv J Shah, Donald M Lloyd-Jones
Journal: Circulation (2019)

Introduction: Albuminuria, measured by urine albumin-to-creatinine ratio (UACR) levels, is linked to maladaptive cardiac remodeling and adverse clinical outcomes. The longitudinal patterns of chang...
Nayneeta Subodh Deshmukh
Authors: Ujjwala Anand Mohite
Journal: BMJ (2021)

Nayneeta Subodh Deshmukh (“Neeta”) did her MD in pathology in 1989 and came to the UK in 1990 to pursue her career in histopathology. She did her specialist training in Liverpool and obtained her royal college membership in 1994.

She worked as consultant at the Royal Orthopaedic Hospital, Birmingham, from 1999 …
Incidence of and Risk Factors for Chemotherapy-Induced Anaphylaxis Agents in the United States
Authors: Leyla Bojanini, Ismael Carrillo-Martin, Yenny Moreno Vanegas, Lyda Cuervo-Pardo, Ricardo Zwiener, Alexei Gonzalez-Estrada
Journal: Journal of Allergy and Clinical Immunology (2021)
Colon tissue-accumulating mesoporous carbon nanoparticles loaded with <i>Musca domestica</i> cecropin for ulcerative colitis therapy
Authors: Lun Zhang, Shuiqing Gui, Yinghua Xu, Jiali Zeng, Jian Wang, Qingru Chen, Liqian Su, Ziyan Wang, Rui Deng, Fujiang Chu, Wenbin Liu, Xiaobao Jin, Xuemei Lu
Journal: Theranostics (2021)

Ulcerative colitis (UC) is a modern refractory disease with steadily increasing incidence worldwide that urgently requires effective and safe therapies. Therapeutic peptides delivered using nanocarriers have shown promising developments for the treatment of UC. We developed a novel colon-accumulating oral drug delivery nanoplatform consisting of
Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer’s disease
Authors: Sudha R. Guttikonda, Lisa Sikkema, Jason Tchieu, Nathalie Saurat, Ryan M. Walsh, Oliver Harschnitz, Gabriele Ciceri, Marjolein Sneeboer, Linas Mazutis, Manu Setty, Paul Zumbo, Doron Betel, Lot D. de Witte, Dana Pe’er, Lorenz Studer
Journal: Nature Neuroscience (2021)
Evaluating Safety, Tolerability, and Efficacy of Subcutaneous Human Immunoglobulin 16.5% Administered at Modified Dosing Regimens in Patients with Primary Immunodeficiency Diseases – Study Design
Authors: Isaac Melamed, Sudhir Gupta, Roger Kobayashi, Michael Eppolito, Joanna Maltese, Syed Rizvi, Ai Kobayashi
Journal: Journal of Allergy and Clinical Immunology (2021)
Characterization of the tumor microenvironment and liquid biopsy in head and neck and non-small cell lung cancer
Authors: Arutha Kulasinghe, Joanna Kapeleris, Liz Kenny, Brett Hughes, Majid Warkiani, Ian Vela, Jean-Paul Thiery, Ken O'Byrne, Chamindie Punyadeera
Journal: Cancer Research (2020)

Metastasis in cancer patients is reflected by measurable levels of circulating tumor cells (CTCs) in the blood of cancer patients. CTCs represent cancer cells from the primary and metastatic sites, thereby providing a comprehensive representation of the tumor burden of an individual patient. Recent advancements have shown that PD-1/PD-L1 immune checkpoint therapies have durable responses in a number of solid tumor types. Our study was designed to use multiple CTC enrichment platforms for the capture of CTCs and novel culture formulations for the ex vivo expansion of CTCs. Head and Neck cancer (n=350) and lung cancer (n=150) patients were recruited to investigate the prognostic role of CTCs. In parallel, a subset of HNC tumors were profiled using the NanoString GeoMx Digital Spatial Profiling (DSP) technology using a 44-plex antibody cocktail. We evaluated multiple CTC isolation technologies (CellSearch, filtration, CD45 depletion, Spiral, Straight and novel microfluidic chip technology) using matched patient samples which showed that epitope-independent CTC isolation captured a greater proportion of CTCs. Molecular alterations present in the primary tissue were confirmed in the CTCs by 3D-DNA FISH (EGFR-amplification, ALK-translocations). In HNC, the presence of CTC clusters associated with the development of distant metastatic disease (P=0.0313). HNC CTC-positive patients had shorter progression free survival (Hazard ratio [HR]: 4.946; 95% [CI]:1.571-15.57; P=0.0063) and PD-L1-positive CTCs were found to be significantly associated with worse outcome ([HR]:5.159; 95% [CI]:1.011-26.33; P=0.0485). In a proof of principle study, we were able to demonstrate for the first time, short-term patient derived CTC cultures outside the patient's body and exome sequencing of CTCs cultures confirmed the presence of mutational signatures consistent with The Cancer Genome Atlas (TCGA). Spatial characterization of the tumor microenvironment revealed immune subsets predictive of outcome to immunotherapy. Comprehensive characterization of the tumor microenvironment and liquid biopsy allows for the recapitulation of the molecular diversity present within the tumor, understanding of the disease progression and testing of therapies.
Safety of Peanut (Arachis Hypogaea) Allergen Powder-dnfp in Children and Teenagers With Peanut Allergy: Pooled Analysis From Controlled and Open-Label Phase 3 Trials
Authors: Thomas Casale, A. Wesley Burks, James Baker, Jonathan O’B Hourihane, Kirsten Beyer, Brian Vickery, Stacie Jones, George Du Toit, J. Andrew Bird, Alex Smith, Kari Brown, Stephen Tilles
Journal: Journal of Allergy and Clinical Immunology (2021)
A Phase I and Surgical Study of Ribociclib and Everolimus in Children with Recurrent or Refractory Malignant Brain Tumors: A Pediatric Brain Tumor Consortium Study
Authors: Mariko D. DeWire, Christine Fuller, Olivia Campagne, Tong Lin, Haitao Pan, Tina Young Poussaint, Patricia A. Baxter, Eugene I. Hwang, Andrew Bukowinski, Kathleen Dorris, Lindsey Hoffman, Angela J. Waanders, Matthias A. Karajannis, Clinton F. Stewart, Arzu Onar-Thomas, Maryam Fouladi, Ira J. Dunkel
Journal: Clinical Cancer Research (2021)

Abstract Purpose: Genomic aberrations in cell cycle and PI3K pathways are commonly observed in pediatric brain tumors. This study determined the MTD/recommended phase II dose (RP2D) of ribociclib and everolimus and characterized single-agent ribociclib concentrations in plasma and tumor in children undergoing resection. Patients and Methods: Patients were enrolled in the phase I study according to a rolling 6 design and received ribociclib and everolimus daily for 21 and 28 days, respectively. Surgical patients received ribociclib at the pediatric RP2D (350 mg/m2) for 7–10 days preoperatively followed by enrollment on the phase I study. Pharmacokinetics were analyzed for both cohorts. Results: Sixteen patients were enrolled on the phase I study (median age, 10.3 years; range, 3.9–20.4) and 6 patients in the surgical cohort (median age, 11.4 years; range: 7.2–17.1). Thirteen patients were enrolled at dose level 1 without dose-limiting toxicities (DLT). Two of the 3 patients at dose level 2 experienced DLTs (grade 3 hypertension and grade 4 alanine aminotransferase). The most common grade 3/4 toxicities were lymphopenia, neutropenia, and leukopenia. The RP2D of ribociclib and everolimus was 120 and 1.2 mg/m2 for 21 and 28 days, respectively. Steady-state everolimus exposures with ribociclib were 2.5-fold higher than everolimus administered alone. Ribociclib plasma, tumor concentrations, and cerebrospinal fluid (CSF) samples were collected. The mean tumor-to-plasma ratio of ribociclib was 19.8 (range, 2.22–53.4). Conclusions: Ribociclib and everolimus were well-tolerated and demonstrated pharmacokinetic properties similar to those in adults. Potential therapeutic ribociclib concentrations could be achieved in CSF and tumor tissue, although interpatient variability was observed.
Coronary Artery Calcium for the Allocation of GLP-1RA for Primary Prevention of Atherosclerotic Cardiovascular Disease
Authors: Miguel Cainzos-Achirica, Kershaw V. Patel, Renato Quispe, Parag H. Joshi, Amit Khera, Colby Ayers, Joao A.C. Lima, Jamal S. Rana, Philip Greenland, Marcio S. Bittencourt, Rhanderson Cardoso, Ron Blankstein, Roger S. Blumenthal, Michael J. Blaha, Khurram Nasir
Journal: JACC. Cardiovascular imaging (2021)
Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism
Authors: Xiaoting Sun, Xingkang He, Yin Zhang, Kayoko Hosaka, Patrik Andersson, Jing Wu, Jieyu Wu, Xu Jing, Qiqiao Du, Xiaoli Hui, Bo Ding, Ziheng Guo, An Hong, Xuan Liu, Yan Wang, Qing Ji, Rudi Beyaert, Yunlong Yang, Qi Li, Yihai Cao
Journal: Gut (2021)

Pancreatic ductal adenocarcinoma (PDAC) is the most lethal malignancy and lacks effective treatment. We aimed to understand molecular mechanisms of the intertwined interactions between tumour stromal components in metastasis and to provide a new paradigm for PDAC therapy.
Oral corticoid, aspirin, anticoagulant, colchicine, and furosemide to improve the outcome of hospitalized COVID-19 patients - the COCAA-COLA cohort study
Authors: Jean-Philippe Kevorkian, Amanda Lopes, Damien Sène, Jean-Pierre Riveline, Claire Vandiedonck, Florine Féron, Kladoum Nassarmadji, Stéphane Mouly, Franck Mauvais-Jarvis, Jean-François Gautier, Bruno Mégarbane
Journal: Journal of Infection (2021)
Paying for Telemedicine After the Pandemic
Authors: Ateev Mehrotra, R. Sacha Bhatia, Centaine L. Snoswell
Journal: JAMA (2021)

This Viewpoint discusses the importance of value as policy makers consider the role of telemedicine for the remainder of and following the COVID-19 pandemic, and how to calibrate payment for services to that value in a likely expansion of video and audio-only visits.
Association Between Proton Pump Inhibitor Use and Risk of Asthma in Children
Authors: Yun-Han Wang, Viktor Wintzell, Jonas F. Ludvigsson, Henrik Svanström, Björn Pasternak
Journal: JAMA Pediatrics (2021)

The use of proton pump inhibitors (PPIs) in children has increased substantially in recent years, concurrently with emerging concerns that these drugs may increase the risk of asthma. Whether PPI use in the broad pediatric population is associated with increased risk of asthma is not known.To investigate the association between PPI use and risk of asthma in children.This nationwide cohort study collected registry data in Sweden from January 1, 2007, to December 31, 2016. Children and adolescents 17 years or younger were matched by age and propensity score into 80 870 pairs of those who initiated PPI use and those who did not. Data were analyzed from February 1 to September 1, 2020.Initiation of PPI use.The primary analysis examined the risk of incident asthma with a median follow-up to 3.0 (interquartile range, 2.1-3.0) years. Cox proportional hazards regression was used to estimate hazard ratios (HRs).Among the 80 870 pairs (63.0% girls; mean [SD] age, 12.9 [4.8] years), those who initiated PPI use had a higher incidence rate of asthma (21.8 events per 1000 person-years) compared with noninitiators (14.0 events per 1000 person-years), with an HR of 1.57 (95% CI, 1.49-1.64). The risk of asthma was significantly increased across all age groups and was highest for infants and toddlers with an HR of 1.83 (95% CI, 1.65-2.03) in the group younger than 6 months and 1.91 (95% CI, 1.65-2.22) in the group 6 months to younger than 2 years (P < .001 for interaction). The HRs for individual PPIs were 1.64 (95% CI, 1.50-1.79) for esomeprazole, 1.49 (95% CI, 1.25-1.78) for lansoprazole, 1.43 (95% CI, 1.35-1.51) for omeprazole, and 2.33 (95% CI, 1.30-4.18) for pantoprazole. In analyses of the timing of asthma onset after PPI initiation, the HRs were 1.62 (95% CI, 1.42-1.85) for 0 to 90 days, 1.73 (95% CI, 1.52-1.98) for 91 to 180 days, and 1.53 (95% CI, 1.45-1.62) for 181 days to end of follow-up. The association was consistent through all sensitivity analyses, including high-dimensional propensity score matching (HR, 1.48; 95% CI, 1.41-1.55).In this cohort study, initiation of PPI use compared with nonuse was associated with an increased risk of asthma in children. Proton pump inhibitors should be prescribed to children only when clearly indicated, weighing the potential benefit against potential harm.
Abstract 17119: Sufficient Pulmonary Vascular Bed Before Fontan Surgery Secures Favorable Fontan Hemodynamics
Authors: Seiko Kuwata, Hirofumi Saiki, Manabu Takanashi, Kenji Sugamoto, Hideaki Senzaki
Journal: Circulation (2018)

Introduction: While improvement of perioperative care markedly expanded candidacy of Fontan surgery, increasing number of Fontan patients is currently subjected to advanced heart failure therapies. Low pulmonary flow before Fontan procedure has been considered to be acceptable as it keeps pulmonary resistance low, however, compromised growth of pulmonary vascular bed after Fontan completion may deteriorate potential to preserve better Fontan circulation later. We tested our hypothesis that sufficient growth of pulmonary vascular bed before Fontan surgery chronically preserves favorable Fontan hemodynamics and prevents patients from cardiovascular remodeling. Methods and Results: Consecutive 33 patients who had undergone Fontan operation (median year after the surgery: 5.3years) were enrolled in this study. During cardiac catheterization, pulmonary arterial index (PAI) as the representative of vascular bed both before and after Fontan procedure was measured and hemodynamics as well as blood samples as a marker for end-organ dysfunction were analyzed. Before Fontan procedure, PAI ranged 74-426 and resistance of pulmonary artery (PAR) ranged 0.4-3.1. After median of 5.3 years of Fontan procedure, CVP exhibited modest decline with preserving cardiac index (CI). Interestingly, central venous pressure (CVP) with chronic Fontan circulation was negatively correlated with PAI of pre-Fontan procedure (P=0.02) whereas it was independent of PAR. Consistent with this, higher PAI before Fontan procedure was also significantly associated with higher CI (P&lt;0.01) and lower levels of plasma brain natriuretic peptides (P=0.03). Importantly, patients with low PAI showed markedly elevated activation of renin-angiotensin-aldosterone (RAAS) activation and elevation of serum gamma-gltamyl transferase (P&lt;0.01), a surrogate marker of liver congestion. Multivariate analysis revealed that high PAI was determinant of low CVP in the chronic Fontan patients, independent of body size, postoperative interval and pulmonary arterial resistance. Conclusion: Sufficient pulmonary vascular bed before Fontan procedure independently lowers CVP, may prevent cardiovascular remodeling by RAAS suppression as well as end organ dysfunction in chronic Fontan patients. Our result suggested importance of strategies to accelerate pulmonary vascular growth before Fontan procedure.