tbuckley/cabot-search huggingface dataset:
Immune-Mediated Reprogramming of Intestinal Stem Cells Drives STAT1-Dependent Myc Expression and Epithelial Regeneration in GI-Gvhd
Authors: Shuichiro Takashima, Roshan Sharma, Anastasiya Egorova, Jason Kuttiyara, Takahiro Ito, Winston Chang, Suze A Jansen, Chen Liu, Caroline Lindemans, Linas Mazutis, Nicolas Robine, Alan M Hanash
Journal: Blood (2021)
CD19/BAFF-R Dual-Targeted CAR T Cells for the Treatment of Mixed Antigen-Negative Variants of Acute Lymphoblastic Leukemia
Authors: Xiuli Wang, Zhenyuan Dong, Wen-Chung Chang, Wesley Cheng, Vibhuti Vyas, Dennis Awuah, Soung-chul Cha, Aaron Anderson, Mary C. Clark, Stephen J Forman, Larry W. Kwak, Hong Qin
Journal: Blood (2021)
Expanded Access Program: Evaluating Safety of Erythrocytes Encapsulating L-Asparaginase in Combination with Polychemotherapy in Patients Under 55 Years Old with Acute Lymphoblastic Leukaemia (ALL) at Risk to Receive Other Formulations of Asparaginase
Authors: Yves Bertrand, Nicolas Boissel, Claudine Schmitt, Alban Villate, Emmanuel Gyan, Bruno Quesnel, Christian Recher, Pauline Simon, Nathalie Cheikh, Marilyne Poirée, Jean Stephan, Cecile Dumesnil, Iman El-Hariry
Journal: Blood (2021)
Genomic Drivers of Large B-Cell Lymphoma Resistance to CD19 CAR-T Therapy
Authors: Michael D. Jain, Bachisio Ziccheddu, Caroline A. Coughlin, Rawan Faramand, Anthony J. Griswold, Kayla M Reid, Ola Landgren, Frederick L. Locke, Francesco Maura, Marco L. Davila, Jonathan H. Schatz
Journal: Blood (2021)
Wearable sensor derived decompensation index for continuous remote monitoring of COVID-19 diagnosed patients
Authors: Dylan M. Richards, MacKenzie J. Tweardy, Steven R. Steinhubl, David W. Chestek, Terry L. Vanden Hoek, Karen A. Larimer, Stephan W. Wegerich
Journal: npj Digital Medicine (2021)

The COVID-19 pandemic has accelerated the adoption of innovative healthcare methods, including remote patient monitoring. In the setting of limited healthcare resources, outpatient management of individuals newly diagnosed with COVID-19 was commonly implemented, some taking advantage of various personal health technologies, but only rarely using a multi-parameter chest-patch for continuous monitoring. Here we describe the development and validation of a COVID-19 decompensation index (CDI) model based on chest patch-derived continuous sensor data to predict COVID-19 hospitalizations in outpatient-managed COVID-19 positive individuals, achieving an overall AUC of the ROC Curve of 0.84 on 308 event negative participants, and 22 event positive participants, out of an overall study cohort of 400 participants. We retrospectively compare the performance of CDI to standard of care modalities, finding that the machine learning model outperforms the standard of care modalities in terms of both numbers of events identified and with a lower false alarm rate. While only a pilot phase study, the CDI represents a promising application of machine learning within a continuous remote patient monitoring system.
Quantitative imaging of apoptosis following oncolytic virotherapy by magnetic resonance fingerprinting aided by deep learning
Authors: Or Perlman, Hirotaka Ito, Kai Herz, Naoyuki Shono, Hiroshi Nakashima, Moritz Zaiss, E. Antonio Chiocca, Ouri Cohen, Matthew S. Rosen, Christian T. Farrar
Journal: Nature Biomedical Engineering (2021)
Interrogating Post-Transcriptional Mechanisms of Fetal Hemoglobin Regulation
Authors: Aoi Wakabayashi, Maryanne Kihiu, Malini Sharma, Mathieu Quesnel-Vallieres, Osheiza Abdulmalik, Scott A. Peslak, Cheryl A. Keller, Belinda Giardine, Ross C. Hardison, Junwei Shi, Gerd A. Blobel
Journal: Blood (2021)
Characterisation of a New Clinical Presentation of Chronic Lymphocytic Leukemia with Symptomatic Nasopharyngeal Mucosa Involvement
Authors: Thimali Ranaweera Arachchige, Antoine Diep, Ambroise David, Melchior Le Mene, Virginie Eclache, Rémi Letestu, Xavier Troussard, Antoine Martin, Catherine Mendiburu, Fanny Baran-Marszak, Florence Cymbalista, Gregory Lazarian
Journal: Blood (2021)
A Novel FBXO45-Gef-H1 Axis Controls Oncogenic Signaling in B-Cell Lymphoma
Authors: Anagh Anant Sahasrabuddhe, Xiaofei Chen, Kaiyu Ma, Rui Wu, Richa Kapoor, Rishi Raj Chhipa, Xiao Zhang, Ozlem Onder, Joel Wilmore, Brian T. Gaudette, Vinodh Pillai, Marilyn M. Li, Joon-Young Ahn, Fuzon Chung, Philippe Szankasi, Venkatesha Basrur, Kevin P Conlon, Nathanael G. Bailey, Cory M Hogaboam, Robert Rottapel, Junhyong Kim, Cristina Lopez, Julian Seufert, Matthias Schlesner, Reiner Siebert, Michael P Cancro, David Allman, Michele Pagano, Louis M. Staudt, Megan S. Lim, Kojo S. J. Elenitoba-Johnson
Journal: Blood (2021)
Practice Patterns and Predictors of Severe Toxicity Among Older Adults with Diffuse Large B Cell Lymphoma Treated with Frontline Chemoimmunotherapy
Authors: Star Ye, Mayur Narkhede, Sean Patrick Bliven, Gaurav Goyal, Amitkumar Mehta, Christian Harmon, Deanna Clark, Clare Ubersax, Sunil Rangarajan, Grant R Williams, Smith Giri
Journal: Blood (2021)
COVID Vaccine Antibody Responses in Patients with Hematologic Malignancies in a Myeloid Enriched Cohort: A Better Antibody Response in Patients with Myeloid Malignancies Than B-Cell Malignancies
Authors: Suleyman Y Goksu, John Rolwes, Naveen Premnath, Prapti Patel, Ruth Ikpefan, Gurbakhash Kaur, Madhuri Vusirikala, Taha Bat, Weina Chen, Praveen Ramakrishnan, Ankit Kansagra, Larry D. Anderson, Farrukh T. Awan, Robert H. Collins, Stephen Chung, Yazan F. Madanat
Journal: Blood (2021)
<i>TP53</i> Mutations, Deletions, and CN-LOH: Comparison of <i>TP53</i> single Hit and Double Hit Events and Their Impact on Prognosis in Hematological Malignancies
Authors: Anna Stengel, Heiko Müller, Manja Meggendorfer, Wencke Walter, Constance Baer, Niroshan Nadarajah, Stephan Hutter, Wolfgang Kern, Torsten Haferlach, Claudia Haferlach
Journal: Blood (2021)
Abstract 9049: Masking the Bruce Protocol: Surgical Masks Decrease Exercise Duration
Authors: Adam Prince, Zachary Giesen, Milbridge Andrew, Benjamin J Seifer, Prajesh Gongal, Stephen Kearing, Caitlin Desaulniers, David Peritz
Journal: Circulation (2021)

Introduction: Exercise stress echocardiography is a critical tool in the workup and assessment of angina, dyspnea, and cardiac disease. Due to the ongoing COVID-19 pandemic, the American Society of Echocardiography recommends that all patients wear surgical facemasks during exercise stress testing. Hypothesis: We hypothesized that masks decrease test duration, increase likelihood of test stoppage due to dyspnea, and increase likelihood of abnormal test results. Methods: We performed a retrospective chart review of 565 treadmill stress echocardiograms utilizing Bruce protocol between April 2019-July 2019 (without mask) and April 2020-July 2020 (with mask). Chi square and T testing were used for statistical analysis, controlling for age and gender. Results: Unmasked patients had a greater mean exercise duration than masked patients (8:12 min vs 7:35 min, p=.02), and were less likely to have dyspnea during the test than masked patients (odds ratio 0.58 [95% CI 0.39, 0.83], p=.003). Unmasked patients were twice as likely to develop chest pain during the test than masked patients (odds ratio 2.0 [95% CI 1.26, 3.22], p=.003). Lastly, unmasked patients were less likely to have an abnormal test result than masked patients, though the difference was not significant (odds ratio 0.81 [95% CI 0.43, 1.51], p=0.50). Conclusions: Surgical mask use during treadmill exercise stress tests associated with a significant decrease in test duration, increased dyspnea during the test, and a non-significant increase in likelihood of abnormal test result. Given the critical importance of stress testing in ischemia evaluation, further exploration is warranted to determine whether mask use during stress tests affects downstream testing, diagnoses, and outcomes.
A Novel Spirocyclic Dimer (36-286) Targeting the NF-Kappa B Pathway Displays Potent Anti-Tumor Properties in Chronic Lymphocytic Leukemia
Authors: Alexandria P Eiken, Audrey L Smith, Sarbjit Singh, Sandeep Rana, Sunandini Sharma, Amarnath Natarajan, Dalia ElGamal
Journal: Blood (2021)
Acute Myeloid Leukemia Cell-Intrinsic PD-1 Functions Promoting Leukemia Development By Recruiting SHP2
Authors: Shanshan Suo, Le Xuan Truong Nguyen, Fenglin Li, Dandan Zhao, Junjing Qiao, Chen Liang, Dinh Hoa Hoang, Fang Chen, Ivan Rodriguez, Lucy Ghoda, Tinisha McDonald, Ling Li, Bin Amber Zhang, Jie Jin, Guido Marcucci
Journal: Blood (2021)
Abstract 10133: Cerebrovascular Imaging Biomarkers, Neuropsychiatric Symptoms, and Mild Cognitive Impairment
Authors: Maria Vassilaki, Jeremy Syrjanen, Eugene Scharf, Janina Krell-Roesch, Prashanthi Vemuri, Jonathan Graff-radford, Michelle Mielke, Mary M. Machulda, Walter Kremers, Val Lowe, Clifford Jack, David Knopman, Ronald Petersen, Yonas E. Geda
Journal: Circulation (2021)

Introduction: Cerebrovascular disease (CVD) and neuropsychiatric symptoms (NPS) are common in older adults and are independently associated with cognitive impairment. In addition, vascular depression (a late-life depression) is hypothesized to be associated with cerebrovascular pathology. Hypothesis: CVD pathology imaging biomarkers (e.g., white matter hyperintensities (WMH), infarctions) are associated with depression and anxiety, and both (depression/anxiety and CVD imaging biomarkers) are independently associated with mild cognitive impairment (MCI). Methods: This cross-sectional study included 1739 Mayo Clinic Study of Aging participants (≥50 years old) without dementia, with comprehensive cognitive evaluations and available data on the Beck Depression Inventory II (BDI), the Beck Anxiety Inventory (BAI) and imaging CVD biomarkers via FLAIR-MRI (i.e., WMH% of total intracranial volume (TIV) and brain infarctions). We used linear and logistic regression models to examine the associations adjusting for age, sex, education, and apolipoprotein E ε4 status. Results: Participants’ mean age (SD) was 71.11 (10.61) years (53.3% males). Higher WMH% TIV burden was significantly associated with higher BDI (b= 0.082, 95%CI: 0.031, 0.133), p=0.002) and BAI scores (b= 0.088, 95%CI: 0.037, 0.140), p=0.001); the presence of infarctions was also associated with a higher BDI score. Both WMH %TIV burden (OR: 1.20 (95%CI:1.05, 1.38), p=0.008) and BDI score (OR: 1.38 (95%CI:1.21, 1.57), p&lt;0.001) were significantly associated with MCI when included simultaneously in the model. We observed similar associations for CVD biomarkers and BAI score with MCI. Conclusions: CVD imaging biomarkers and NPS, as measured by BDI and BAI scores, could represent two distinct processes associated with cognitive impairment. Studies are ongoing to further examine these associations and delineate how CVD, NPS, and other pathophysiology processes (e.g., Alzheimer’s disease) interact and are associated with cognitive impairment.
G-CSF/Plerixafor Dual-Mobilized Donor Derived CD33CAR T-Cells As Potent and Effective AML Therapy in Pre-Clinical Models
Authors: Giacomo Canesin, Hillary Hoyt, Reid Williams, Mariana Silva, Melissa Chng, Christopher Cummins, Matthew Ung, Huan Qiu, John Shin, Jianxin Hu, Gary Ge, Julian Scherer, Tirtha Chakraborty, Sadik Kassim
Journal: Blood (2021)
NGS Evaluation of the Eqol-MDS Trial: Preliminary Analysis of Eltrombopag for Thrombocytopenia of Low-Risk MDS
Authors: Esther Natalie Oliva, Corrado Mammi', Maria Cuzzola, Yasuhito Nannya, Austin G. Kulasekararaj, Maria Grazia D'Errigo, Maria Concetta Cannatà, Gina Zini, Roberto Latagliata, Pasquale Niscola, Valeria Santini, Marta Riva, Isabella Capodanno, Sabrina Greve, Alexander E Smith, Seishi Ogawa
Journal: Blood (2021)
Role of Extracorporeal Photopheresis in Prevention of Graft-Versus-Host Disease in Patients Treated with Allogeneic Hematopoietic Stem Cell Transplantation: A Randomized Controlled Trial
Authors: Maryan M Ali, Tobias Gedde-Dahl, Marit B Veierød, Geir E Tjønnfjord, Per Ole Iversen
Journal: Blood (2021)
CAR Density Influences Antitumoral Efficacy of BCMA CAR-T Cells and Correlates with Clinical Outcome
Authors: Paula Rodriguez-Marquez, Maria Erendira Calleja-Cervantes, Guillermo Serrano, Maria Luisa Palacios-Berraquero, Diego Alignani, Patxi San Martin-Uriz, Amaia Vilas-Zornoza, Candela Ceballos, Angel Martin-Mallo, Saray Rodríguez-Diaz, Rebeca Martínez-Turrillas, Patricia Jauregui, Cristina Calviño, Susana Inogés, Ascensión López-Diaz de Cerio, Aina Oliver-Caldés, Marta Español-Rego, Mariona Pascal, Beatriz Martin-Antonio, Manel Juan, Álvaro Urbano-Ispizua, Carlos Fernández De Larrea, Maria Cruz Viguria, Ana Margarita Redondo, Paula Rodríguez-Otero, Jose J. Rifon Roca, Ana Alfonso Pierola, Juan Jose Lasarte, Teresa Lozano, Bruno Paiva, Jesús F. San-Miguel, Mikel Hernáez, Juan Roberto Rodriguez-Madoz, Felipe Prósper
Journal: Blood (2021)
Abstract 10735: Conduction Abnormalities and Pacemaker Implantation in Patients with Radiation-Associated Cardiac Disease
Authors: Samantha Xu, Wynne Zheng, Susan Ospina, Eoin Donnellan, Brian P Griffin, Douglas Johnston, Samir R Kapadia, Bruce L Wilkoff, Milind Y Desai
Journal: Circulation (2021)

Introduction: We sought to study prevalence of conduction disease and permanent pacemaker (PPM) in patients presenting with radiation-associated cardiac disease (RACD) and its impact on long-term survival. Methods: We studied 699 patients with documented RACD (prior chest radiotherapy at a mean of 22 years prior) evaluated at a single center from 1998-2018. Conduction abnormalities and PPM at baseline were recorded, along with cardiac procedures performed during follow-up. Death was the primary endpoint. Results: Patients were divided into 4 groups: 1) no procedure during follow-up 2) 1 valve or coronary artery bypass grafting (CABG) or 1-valve+CABG surgery 3) Multivalve+/-CABG+/-aortic/pericardial surgery and 4)Trans catheter aortic valve replacement (TAVR). Relevant characteristics and outcomes are shown in Table. In total, 183 patients had a PPM (82 [45%] implanted during follow-up). Over a mean follow-up of 5±4 years (range 0-21 years), 370 patients (53%) patients died. On survival analysis, presence of PPM (HR 1.26 [1.03-1.54], p=0.03) was independently associated with higher long-term mortality; 109 (60%) patients with PPM died in the long-term vs. those without261 (51%, log-rank p-value=0.03). Conclusion: RACD patients have a high rate of mortality during longer-term follow-up, despite a low calculated preoperative risk. In addition, they have a high rate of conduction abnormalities with a high proportion requiring PPM, including at baseline, irrespective of need for a cardiac procedure. Presence of a PPM was independently associated with long-term risk of mortality.
Coronary Artery Embolism and Antiphospholipid Syndrome: A Case Report and Review of the Literature
Authors: Yanrong Liu, Dianfu Li, Tianbao Xu, Esmayilaji Patiway, Gulistan Alim, Chenghui Tong, Jinghe Zhao, Patigul Rozi, Eslamgul Hayrilla, Zemu Wang
Journal: Clinical Cardiology and Cardiovascular Interventions (2020)

Coronary artery embolism is an uncommon cause of acute myocardial infarction (AMI), while antiphospholipid syndrome (APS) is one of the rare reasons due to premature AMI. Coronary angiography can diagnose coronary artery embolism, and the positive serum of aPLs may infirm APS. We report a 32 years old man with ST-elevation AMI, without any high-risk factors of coronary artery disease. Coronary thrombosis was founded in the M1 sub-coronary of Left Anterior Descending (LAD), and the coronary artery was recanalized, the artery was not obstructive, Thrombolysis in Myocardial Infarction (TIMI) grade was III. He became shortness after exercise, the echocardiography showed his left ventricular was enlarged and LVEF was decreased. High titers of an anticardiolipin antibody (aCL) IgG of 46U (positive &gt;20.0U), and it was positive at two dosages with an interval greater than 12 weeks. But there was no evidence of any other serum markers suggesting other associated pathologies such as SLE, so the primary APS was diagnosed. We gave him anticoagulation with warfarin and a single antiplatelet with Aspirin, the target INR was 2.5-3.0. Meanwhile, statins and hydroxychloroquine (HCQ) were all prescribed. After 6-months follow-up, his heart failure symptoms were disappeared, the LVDd and LVEF were all normal, the titer was decreased to nearly normal. In clinical background, young AMI without traditional high-risk factors of CAD, we should suspect APS. Therefore, we believed that HCQ may low thrombotic rate, down-trending aPLs titer, and prevent thrombotic recurrences in patients with primary antiphospholipid syndrome.
Abstract PO-101: Characterization of longitudinally collected fine needle aspiration biopsies of pancreatic ductal adenocarcinoma upon endoscopic ultrasound guided radiofrequency ablation
Authors: Krisha Desai, Patrick Varun Lawrence, Christopher Wadsworth, Nagina Mangal, Nagy Habib, Anguraj Sadanandam, Mikael Sodergren
Journal: Cancer Research (2021)

Abstract Background: Most patients with pancreatic ductal adenocarcinoma (PDAC) are metastatic at presentation with dismal prognosis warranting improved systemic therapy options. Longitudinal sampling for assessment of treatment response poses a challenge for validating novel therapies. In this proof-of-principle study, we evaluate the role of endoscopic ultrasound (EUS)-guided serial fine-needle aspiration biopsies (FNABs) to study the mechanism of action of radiofrequency ablation (RFA). Methods: Patients with stage III inoperable PDAC with prior exposure to gemcitabine were selected into ARDEO (ethically approved Phase-II prospective clinical study of EUS-RFA). Post examination, targeted RF was delivered thrice and sequential FNABs of tumor were taken before and after treatment. Transcriptomic profiling of 6 FNABs from 2 patients was performed using a custom NanoString gene panel (144 genes) consisting of cancer and cancer-associated fibroblast (CAFs) subtypes along with immune changes. CAF culture was established from one FNAB and characterised by immunofluorescence and immunoblotting. Results: RFA treatments were well tolerated without any complications and both patients had stable disease immediately after EUS-RFA. Two-course RFA led to upregulation of CD1E gene (participates in antigen presentation) in both, patient 1 and 2 (4.5 and 3.9-fold) compared to baseline. Patient 1 showed increased expression of T cell genes (CD4 – 8.7-fold, CD8 – 35.7-fold), cytolytic function (6.4-fold) and inflammatory response (8-fold) post-RFA. Greater than 2-fold upregulation of CD274 (PDL1), IDO1, PDCD1 and TNFRSF18 (GITR) was observed post 2nd RFA in both the patients. Further, two-course RFA led to increased PDGFRa (4.5 and 9-fold) in both patients along with enrichment of pCAF subtypes B and C in patient 1 and subtypes A, B and D in patient 2. Immunofluorescence staining revealed expression of PDGFRa, aSMA, VIM, POSTN and MYH11 on patient2-derived CAFs post 1st RFA; validated by immunoblotting. Finally, RFA led to downregulation of classical PDA subtype in both patients. Conclusions: This feasibility study validates longitudinal sampling by EUS-FNABs as an appropriate research tool to study tumor microenvironmental changes associated with local pancreatic immunomodulatory techniques like RFA. Citation Format: Krisha Desai, Patrick Varun Lawrence, Christopher Wadsworth, Nagina Mangal, Nagy Habib, Anguraj Sadanandam, Mikael Sodergren. Characterization of longitudinally collected fine needle aspiration biopsies of pancreatic ductal adenocarcinoma upon endoscopic ultrasound guided radiofrequency ablation [abstract]. In: Proceedings of the AACR Virtual Special Conference on Pancreatic Cancer; 2021 Sep 29-30. Philadelphia (PA): AACR; Cancer Res 2021;81(22 Suppl):Abstract nr PO-101.
Impact of Diagnosis-to-Treatment Interval on Overall Survival in Patients with Mantle Cell Lymphoma: A National Cancer Database Analysis
Authors: Xavier Andrade-Gonzalez, Allison M. Bock, Jacqueline Wang, Antoine Saliba, Javier Munoz, David J. Inwards, Jonas Paludo, Thomas M. Habermann, Grzegorz S. Nowakowski, Yucai Wang
Journal: Blood (2021)
Incidence and Outcomes of Toxoplasma Reactivation in Patients with Hematologic Diseases after Allogeneic Hematopoietic Stem Cell Transplantation
Authors: Taha Al-Juhaishi, Alexandre Elias Malek, Denái R. Milton, Jeremy L. Ramdial, May Daher, Amanda L. Olson, Samer A. Srour, Gheath Alatrash, Betul Oran, Rohtesh S. Mehta, Issa F. Khouri, Qaiser Bashir, Nina Shah, Stefan O. Ciurea, Gabriela Rondon, Farzaneh Maadani, Chitra Hosing, David Marin, Partow Kebriaei, Katayoun Rezvani, Yago Nieto, Paolo Anderlini, Amin M. Alousi, Muzaffar H. Qazilbash, Uday R. Popat, Richard E. Champlin, Elizabeth J. Shpall, Victor Mulanovich, Sairah Ahmed
Journal: Blood (2021)
Wall Shear Stress Predicts Aortic Dilation in Patients With Bicuspid Aortic Valve
Authors: Andrea Guala, Lydia Dux-Santoy, Gisela Teixido-Tura, Aroa Ruiz-Muñoz, Laura Galian-Gay, Maria Luz Servato, Filipa Valente, Laura Gutiérrez, Teresa González-Alujas, Kevin M. Johnson, Oliver Wieben, Guillem Casas-Masnou, Augusto Sao Avilés, Ruben Fernandez-Galera, Ignacio Ferreira-Gonzalez, Arturo Evangelista, Jose F. Rodríguez-Palomares
Journal: JACC. Cardiovascular imaging (2021)
Hispanic or Latin American Ancestry Is Associated with a Similar Genomic Profile and a Trend Toward Inferior Outcomes in Newly Diagnosed Multiple Myeloma As Compared to Non-Hispanic White Patients in the Multiple Myeloma Research Foundation (MMRF) CoMMpassstudy
Authors: Louis Williams, Patrick Blaney, Eileen M Boyle, Hussein Ghamlouch, Yubao Wang, Jinyoung Choi, Michael A Bauer, Ariel Siegel, James Stoeckle, Beatrice Razzo, Daniel Auclair, David Kaminetzky, Marc Braunstein, Benedetto Bruno, Arnaldo A. Arbini, Brian A Walker, Faith E. Davies, Gareth J Morgan
Journal: Blood (2021)
Nilotinib and Dasatinib Evoked Distinct Immune Effects during Tfr Phase of Each Discontinuation Trial
Authors: Yuki Fujioka, Naoto Takahashi, Shigeki Ohtake, Yoshiko Atsuta, Yosuke Minami, Noriyoshi Iriyama, Hitoshi Kiyoi, Yasushi Miyazaki, Itaru Matsumura
Journal: Blood (2021)
Ultrathin 2D Titanium Carbide MXene (Ti<sub>3</sub>C<sub>2</sub>T<i><sub>x</sub></i>) Nanoflakes Activate WNT/HIF‐1<i>α</i>‐Mediated Metabolism Reprogramming for Periodontal Regeneration (Adv. Healthcare Mater. 22/2021)
Authors: Di Cui, Na Kong, Liang Ding, Yachong Guo, Wenrong Yang, Fuhua Yan
Journal: Advanced Healthcare Materials (2021)

Periodontal Tissue Engineering In article number 2101215 by Yachong Guo, Wenrong Yang, Fuhua Yan, and co-workers, 2D nanoflakes of MXene (Ti3C2Tx) enhance hPDLCs osteogenetic differentiation in vitro and periodontal regeneration in a rat periodontal defect mode by activating WNT/HIF-1α-mediated metabolism reprogramming. The results imply that Ti3C2Tx might be a potential therapeutic option in periodontal tissue engineering and treatment of periodontitis.