SAT0453 DELAYED DENOSUMAB INJECTIONS AND FRACTURES RISK AMONG SUBJECTS WITH OSTEOPOROSIS: A POPULATION-BASED COHORT STUDY
Authors: H. Lyu, K. Yoshida, S. S. Zhao, X. García-Albéniz, J. Wei, C. Zeng, S. Tedeschi, B. Leder, G. Lei, P. Tang, D. Solomon
Journal: Annals of the Rheumatic Diseases (2020)

Background: Denosumab is effective for osteoporosis, but discontinuation leads to rapid reversal of its therapeutic effect[1]. Objectives: To estimate the risk for fracture among users of denosumab who delayed subsequent dosages compared with users who received dosages on time. Methods: Population-based cohort study. We included patients aged over 45 years who initiated denosumab for osteoporosis from UK THIN database, 2010 to 2019. Observational data were used to “emulate a hypothetical trial”[2, 3] with three dosing intervals: subsequent denosumab injection 24-28 weeks after prior dose (“on time”), delay by 4-16 weeks (“short delay”), and delay by over 16 weeks (“long delay”). The primary outcome was a composite of all fracture types. Secondary outcomes included major osteoporotic fracture, vertebral fracture, and hip fracture. Results: The rate of composite fracture per 1000 person-years was 58.9 for on-time, 61.7 for short delay, and 85.4 for long delay of subsequent denosumab injections. Compared to on-time injections, short delay had a hazard ratio (HR) for composite fracture 1.03 (95% CI 0.63-1.69) and long delay HR 1.44 (95% CI 0.96-2.17; p for trend 0.093). For major osteoporotic fractures, short delay had an HR 0.94 (95% CI 0.57-1.55) and long delay an HR of 1.69 (95% CI 1.01-2.83; p for trend 0.056). For vertebral fractures, short delay had an HR 1.48 (95% CI 0.58-3.79) and long delay 3.91 (95% CI 1.62-9.45; p for trend 0.005). Conclusion: While delayed subsequent denosumab dosages over 16 weeks was associated with an increased risk of vertebral and major osteoporotic fracture compared to no delay, composite fracture risk was not increased with longer delays. References: [1]Cummings SR, Ferrari S, Eastell R, et al. Vertebral Fractures After Discontinuation of Denosumab: A Post Hoc Analysis of the Randomized Placebo-Controlled FREEDOM Trial and Its Extension. J Bone Miner Res, 2017. [2]Hernán MA. How to estimate the effect of treatment duration on survival outcomes using observational data. BMJ 2018. [3]Hernán MA, Robins JM. Using Big Data to Emulate a Target Trial When a Randomized Trial Is Not Available. Am J Epidemiol 2016. Table. Rates and Adjusted Hazard Ratios of Fracture On-time Short delay Long delay P for linear trend Composite Fracture Rate (per 1000 person-years) 59 61.7 85.4 - Unadjusted HR (95 %) Ref 1.05 (0.62, 1.76) 1.45 (0.95, 2.21) 0.097 Adjusted HR (95% CI) † Ref 1.03 (0.63, 1.69) 1.44 (0.96, 2.17) 0.093 Major Osteoporotic Fracture Rate (per 1000 person-years) 34.8 31.9 58 - Unadjusted HR (95 %) Ref 0.92 (0.55, 1.53) 1.67 (0.98, 2.84) 0.074 Adjusted HR (95% CI) † Ref 0.94 (0.57, 1.55) 1.69 (1.01, 2.83) 0.056 Vertebral Fracture Rate (per 1000 person-years) 4.9 7.3 19.4 - Unadjusted HR (95 %) Ref 1.47 (0.58, 3.71) 3.93 (1.59, 9.72) 0.006 Adjusted HR (95% CI) † Ref 1.48 (0.58, 3.79) 3.91 (1.62, 9.45) 0.005 Hip Fracture Rate (per 1000 person-years) 10.2 9.6 18.3 - Unadjusted HR (95 %) Ref 0.94 (0.43, 2.04) 1.78 (0.80, 3.97) 0.18 Adjusted HR (95% CI) † Ref 0.97 (0.44, 2.12) 1.75 (0.81, 3.79) 0.173 † Adjusted model: adjusted by age, sex, baseline CCI index, major osteoporotic fracture, oral BP duration (years), 10-year risk of major osteoporotic fracture, prior denosumab doses. Acknowledgments: We acknowledge Dr. Dani Prieto-Alhambra for kindly providing Read codes. Disclosure of Interests: Houchen Lyu: None declared, Kazuki Yoshida: None declared, Sizheng Steven Zhao: None declared, Xabier García-Albéniz: None declared, Jie Wei: None declared, Chao Zeng: None declared, Sara Tedeschi: None declared, Benjamin Leder Grant/research support from: Research funding from Amgen, Guanghua Lei: None declared, Peifu Tang: None declared, Daniel Solomon Grant/research support from: Funding from Abbvie and Amgen unrelated to this work