tbuckley/cabot-search huggingface dataset:
Exploration of sea anemone-inspired high-performance biomaterials with enhanced antioxidant activity
Authors: Lulu Wang, Xiaokang Zhang, Pingping Xu, Jicheng Yan, Yuzhong Zhang, Hainan Su, Chengjun Sun, Qiang Lu, Weizhi Liu
Journal: Bioactive Materials (2021)

Antioxidant biomaterials have attracted much attention in various biomedical fields because of their effective inhibition and elimination of reactive oxygen species (ROS) in pathological tissues. However, the difficulty in ensuring biocompatibility, biodegradability and bioavailability of antioxidant materials has limited their further development. Novel bioavailable antioxidant materials that are derived from natural resources are urgently needed. Here, an integrated multi-omics method was applied to fabricate antioxidant biomaterials. A key cysteine-rich thrombospondin-1 type I repeat-like (TSRL) protein was efficiently discovered from among 1262 adhesive components and then used to create a recombinant protein with a yield of 500 mg L-1. The biocompatible TSRL protein was able to self-assemble into either a water-resistant coating through Ca2+-mediated coordination or redox-responsive hydrogels with tunable physical properties. The TSRL-based hydrogels showed stronger 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging rates than glutathione (GSH) and ascorbic acid (Aa) and protected cells against external oxidative stress significantly more effectively. When topically applied to mice skin, TSRL alleviated epidermal hyperplasia and suppressed the degradation of collagen and elastic fibers caused by ultraviolet radiation B (UVB) irradiation, confirming that it enhanced antioxidant activity in vivo. This is the first study to successfully characterize natural antioxidant biomaterials created from marine invertebrate adhesives, and the findings indicate the excellent prospects of these biomaterials for great applications in tissue regeneration and cosmeceuticals.
Multiparameter Cardiac Magnetic Resonance to Monitor Therapeutic Effect After Chemotherapy in Light Chain Amyloidosis Patients
Authors: Xiao Li, Sisi Huang, Huilei Miao, Kaini Shen, Lu Lin, Jian Wang, Jian Cao, Yajing Liu, Likun Cao, Jian Li, Zhengyu Jin, Yining Wang
Journal: JACC. Cardiovascular imaging (2021)
Clinicopathologic Characteristics, Treatment, and Outcomes of Post-transplant Lymphoproliferative Disorders: A Single-institution Experience Using 2017 WHO Diagnostic Criteria
Authors: Rebecca L. King, Arushi Khurana, Raphael Mwangi, Angelo Fama, Kay M. Ristow, Matthew J. Maurer, William R. Macon, Stephen M. Ansell, N. Nora Bennani, Yogish C. Kudva, Randall C. Walker, Kymberly D. Watt, Thomas R. Schwab, Sudhir S. Kushwaha, James R. Cerhan, Thomas M. Habermann
Journal: HemaSphere (2021)

The World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues (WHO 2017) included updated criteria for diagnosis and classification of post-transplant lymphoproliferative disorders (PTLDs). This study evaluated the clinicopathologic spectrum using WHO 2017 criteria and adult PTLD patients’ outcomes over 30 years between 1987 and 2017 at Mayo Clinic (Rochester, MN). Patients were retrospectively reviewed for clinical features, outcomes, and diagnostic pathology material and classified based on WHO 2017 criteria. A total of 227 patients were diagnosed with PTLD, with a median time from transplant to PTLD of 45 months. PTLD occurred &gt;1 year after transplant in 149 (66%) patients. Monomorphic PTLD was the most common subtype (173, 76%), with diffuse large B cell lymphoma as the commonest morphology (n = 137). Epstein-Barr virus was positive in 61% of total cases and 90% of PTLD that developed within 1 year from transplant. The median event-free survival (EFS) and overall survival for the entire cohort were 21 months (95% confidence interval [CI]: 9–35) and 82 months (95% CI: 39–115), respectively. The EFS or overall survival was not impacted by Epstein-Barr virus status but differed based on WHO subtypes and year of diagnosis. Management changed over time with increased use of rituximab or chemotherapy + immunosuppression reduction as initial therapy. When compared to the matched general population and de novo diffuse large B cell lymphoma, patients not achieving EFS 24 status (no progression/treatment or death within 24 mo of diagnosis) had a worse standardized mortality ratio 16.75 (95% CI: 13.91–20) versus SMR 1.72 (95% CI: 1.26–2.28) in those who achieved EFS24. Cause of death was mostly attributed to non-lymphoma–related causes in those achieving EFS 24.
Insights into the mechanisms underlying aberrant SOX11 oncogene expression in mantle cell lymphoma
Authors: Roser Vilarrasa-Blasi, Núria Verdaguer-Dot, Laura Belver, Paula Soler-Vila, Renée Beekman, Vicente Chapaprieta, Marta Kulis, Ana C. Queirós, Maribel Parra, María José Calasanz, Xabier Agirre, Felipe Prosper, Sílvia Beà, Dolors Colomer, Marc A. Marti-Renom, Adolfo Ferrando, Elías Campo, José Ignacio Martin-Subero
Journal: Leukemia (2021)
Short-term Outcomes of Robotic Gastrectomy vs Laparoscopic Gastrectomy for Patients With Gastric Cancer
Authors: Toshiyasu Ojima, Masaki Nakamura, Keiji Hayata, Junya Kitadani, Masahiro Katsuda, Akihiro Takeuchi, Shinta Tominaga, Tomoki Nakai, Mikihito Nakamori, Masaki Ohi, Masato Kusunoki, Hiroki Yamaue
Journal: JAMA Surgery (2021)

Robotic gastrectomy (RG) for gastric cancer may be associated with decreased incidence of intra-abdominal infectious complications, including pancreatic fistula, leakage, and abscess. Prospective randomized clinical trials comparing laparoscopic gastrectomy (LG) and RG are thus required.To compare the short-term surgical outcomes of RG with those of LG for patients with gastric cancer.In this phase 3, prospective superiority randomized clinical trial of RG vs LG regarding reduction of complications, 241 patients with resectable gastric cancer (clinical stages I-III) were enrolled between April 1, 2018, and October 31, 2020.LG vs RG.The primary end point was the incidence of postoperative intra-abdominal infectious complications. Secondary end points were incidence of any complications, surgical results, postoperative courses, and oncologic outcomes. The modified intention-to-treat population excluded patients who had been randomized and met the postrandomization exclusion criteria. There was also a per-protocol population for analysis of postoperative complications.This study enrolled 241 patients, with 236 patients in the modified intention-to-treat population (150 men [63.6%]; mean [SD] age, 70.8 [10.7] years). There was no significant difference in the incidence of intra-abdominal infectious complications (per-protocol population: 10 of 117 [8.5%] in the LG group vs 7 of 113 [6.2%] in the RG group). Of 241 patients, 122 were randomly assigned to the LG group, and 119 patients were randomly assigned to the RG group. Two of the 122 patients (1.6%) in the LG group converted from LG to open surgery, and 4 of 119 patients (3.4%) in the RG group converted from RG to open or laparoscopic surgery, with no significant difference. Finally, 117 patients in the LG group completed the procedure, and 113 in the RG group completed the procedure; these populations were defined as the per-protocol population. The overall incidence of postoperative complications of grade II or higher was significantly higher in the LG group (23 [19.7%]) than in the RG group (10 [8.8%]) (P = .02). Even in analysis limited to grade IIIa or higher, the complication rate was still significantly higher in the LG group (19 [16.2%]) than in the RG group (6 [5.3%]) (P = .01).This study found no reduction of intra-abdominal infectious complications with RG compared with LG for gastric cancer.umin.ac.jp/ctr Identifier: UMIN000031536.
Cardiovascular care of older adults
Authors: Deirdre E O’Neill, Daniel E Forman
Journal: BMJ (2021)

ABSTRACT Age is an independent risk factor for cardiovascular disease. With the accelerated growth of the population of older adults, geriatric and cardiac care are becoming increasingly entwined. Although cardiovascular disease in younger adults often occurs as an isolated problem, it is more likely to occur in combination with clinical challenges related to age in older patients. Management of cardiovascular disease is transmuted by the context of multimorbidity, frailty, polypharmacy, cognitive dysfunction, functional decline, and other complexities of age. This means that additional insight and skills are needed to manage a broader range of relevant problems in older patients with cardiovascular disease. This review covers geriatric conditions that are relevant when treating older adults with cardiovascular disease, particularly management considerations. Traditional practice guidelines are generally well suited for robust older adults, but many others benefit from a relatively more personalized therapeutic approach that allows for a range of medical circumstances and idiosyncratic goals of care. This requires weighing of risks and benefits amidst the patient’s aggregate clinical status and the ability to communicate effectively about this with patients and, where appropriate, their care givers in a process of shared decision making. Such a personalized approach can be particularly gratifying, as it provides opportunities to optimize an older patient’s function and quality of life at a time in life when these often become foremost therapeutic priorities.
Chronic exertional compartment syndrome
Authors: Mark Hutchinson
Journal: British Journal of Sports Medicine (2011)

The diagnosis of chronic exertional compartment syndrome (CECS) is commonly delayed due to the poor use of terminology by athletes, and many clinicians, that virtually any pain in the leg is ‘shin splints’. We will be able to provide our patients with a better serviceif we can target a more specific diagnosis with earlier and focused treatment. Therefore, when the history and presentation are most consistent with a stress fracture, radiographs and possibly an MRI or a bone scan should be obtained. If the pain is posterior and related to blood flow, venous or arterial Doppler studies or magnetic resonance angiography should be obtained to confirm the diagnosis of a blood clot or popliteal artery syndrome. Finally, when the history includes increasing pain with exertion with associated resolution with rest, the working diagnosis of CECS should be confirmed with intracompartmental pressure testing. Although alternative techniques using infrared sensors have been proposed,1 most experts agree that intracompartmental pressure testing is the gold standard.

Key questions, however, remain regarding the specific protocol a clinician should undergo when performing intracompartmental pressure testing. Should both legs be tested? Should the isolated, most symptomatic compartment or all four compartments be routinely tested? Are resting, immediate postexertion and delayed postexertion tests required for adequate testing?

Classic use of intracompartmental pressure measurements was established for the diagnosis of acute and not CECSs. In general, the clinical presentation for an acute compartment syndrome is more obvious with exquisite, unrelenting pain associated with a palpably tense compartment. In these cases, it is reasonable to test only the suspicious compartment. Indeed, it is within the standard of care to proceed with a fascial release in the acute setting even without confirming elevated pressures with an intracompartmental pressure measurement. For CECS, the standard of care is to confirm the diagnosis …
Guidance for Timely and Appropriate Referral of Patients With Advanced Heart Failure: A Scientific Statement From the American Heart Association
Authors: Alanna A. Morris, Prateeti Khazanie, Mark H. Drazner, Nancy M. Albert, Khadijah Breathett, Lauren B. Cooper, Howard J. Eisen, Patrick O’Gara, Stuart D. Russell
Journal: Circulation (2021)

Among the estimated 6.2 million Americans living with heart failure (HF), ≈5%/y may progress to advanced, or stage D, disease. Advanced HF has a high morbidity and mortality, such that early recognition of this condition is important to optimize care. Delayed referral or lack of referral in patients who are likely to derive benefit from an advanced HF evaluation can have important adverse consequences for patients and their families. A 2-step process can be used by practitioners when considering referral of a patient with advanced HF for consideration of advanced therapies, focused on recognizing the clinical clues associated with stage D HF and assessing potential benefits of referral to an advanced HF center. Although patients are often referred to an advanced HF center to undergo evaluation for advanced therapies such as heart transplantation or implantation of a left ventricular assist device, there are other reasons to refer, including access to the infrastructure and multidisciplinary team of the advanced HF center that offers a broad range of expertise. The intent of this statement is to provide a framework for practitioners and health systems to help identify and refer patients with HF who are most likely to derive benefit from referral to an advanced HF center.
Severe Acute Exacerbation After Cessation of Nucleos(t)ide Analog for Chronic Hepatitis B: A Real-World Study of Routine Practice
Authors: Yao-chun Hsu, Jia-Ling Wu, Cheng-Hao Tseng, Mindie H. Nguyen, Chih-Wen Lin, Chih-Lung Hung
Journal: Clinical Gastroenterology and Hepatology (2021)
TREM-2 promotes Th1 responses by interacting with the CD3ζ-ZAP70 complex following Mycobacterium tuberculosis infection
Authors: Yongjian Wu, Minhao Wu, Siqi Ming, Xiaoxia Zhan, Shengfeng Hu, Xingyu Li, Huan Yin, Can Cao, Jiao Liu, Jinai Li, Zhilong Wu, Jie Zhou, Lei Liu, Sitang Gong, Duanman He, Xi Huang
Journal: Journal of Clinical Investigation (2021)

Triggering receptor expressed on myeloid cells 2 (TREM-2) is a modulator of pattern recognition receptors on innate immune cells that regulates the inflammatory response. However, the role of TREM-2 in in vivo models of infection and inflammation remains controversial. Here, we demonstrated that TREM-2 expression on CD4+ T cells was induced by Mycobacterium tuberculosis infection in both humans and mice and positively associated with T cell activation and an effector memory phenotype. Activation of TREM-2 in CD4+ T cells was dependent on interaction with the putative TREM-2 ligand expressed on DCs. Unlike the observation in myeloid cells that TREM-2 signals through DAP12, in CD4+ T cells, TREM-2 interacted with the CD3ζ-ZAP70 complex as well as with the IFN-γ receptor, leading to STAT1/-4 activation and T-bet transcription. In addition, an infection model using reconstituted Rag2–/– mice (with TREM-2–KO vs. WT cells or TREM-2+ vs. TREM-2–CD4+ T cells) or CD4+ T cell–specific TREM-2 conditional KO mice demonstrated that TREM-2 promoted a Th1-mediated host defense against M. tuberculosis infection. Taken together, these findings reveal a critical role of TREM-2 in evoking proinflammatory Th1 responses that may provide potential therapeutic targets for infectious and inflammatory diseases.
An Important Role of p300 on Mitochondrial Gene Expression and Function and Tolerance to Ischemia in the Heart
Authors: Nakagawa Yasuaki, Kuwahara Koichiro, Akao Masaharu, Katoh Masashi, Takemura Genzou, Harada Masaki, Usami Satoru, Yasuno Shinji, Kinoshita Hideyuki, Fujiwara Masataka, Kuwabara Yoshihiro, Ueshima Kenji, Nakao Kazuwa
Journal: Circulation (2009)
Tumor cell IDO enhances immune suppression and decreases survival independent of tryptophan metabolism
Authors: Lijie Zhai, April Bell, Erik Ladomersky, Kristen L. Lauing, Lakshmi Bollu, Brenda Nguyen, Matthew Genet, Miri Kim, Peiwen Chen, Xinlei Mi, Jennifer D. Wu, Matthew J. Schipma, Brian Wray, John Griffiths, Richard Unwin, Simon Clark, Rajesh Acharya, Riyue Bao, Craig Horbinski, Rimas V. Lukas, Gary E. Schiltz, Derek A. Wainwright
Journal: Clinical Cancer Research (2021)
Multiple Sources of Introduction of North American<i>Arabidopsis thaliana</i>from across Eurasia
Authors: Gautam Shirsekar, Jane Devos, Sergio M Latorre, Andreas Blaha, Maique Queiroz Dias, Alba González Hernando, Derek S Lundberg, Hernán A Burbano, Charles B Fenster, Detlef Weigel
Journal: Molecular Biology and Evolution (2021)

Abstract Large-scale movement of organisms across their habitable range, or migration, is an important evolutionary process that can shape genetic diversity and influence the adaptive spread of alleles. Although human migrations have been studied in great detail with modern and ancient genomes, recent anthropogenic influence on reducing the biogeographical constraints on the migration of nonnative species has presented opportunities in several study systems to ask the questions about how repeated introductions shape genetic diversity in the introduced range. We present an extensive overview of population structure of North American Arabidopsis thaliana by studying a set of 500 whole-genome sequenced and over 2,800 RAD-seq genotyped individuals in the context of global diversity represented by Afro-Eurasian genomes. We use methods based on haplotype and rare-allele sharing as well as phylogenetic modeling to identify likely sources of introductions of extant N. American A. thaliana from the native range in Africa and Eurasia. We find evidence of admixture among the introduced lineages having increased haplotype diversity and reduced mutational load. We also detect signals of selection in immune-system-related genes that may impart qualitative disease resistance to pathogens of bacterial and oomycete origin. We conclude that multiple introductions to a nonnative range can rapidly enhance the adaptive potential of a colonizing species by increasing haplotypic diversity through admixture. Our results lay the foundation for further investigations into the functional significance of admixture.
Effects of Walnut Consumption for 2 Years on Lipoprotein Subclasses Among Healthy Elders
Authors: Sujatha Rajaram, Montserrat Cofán, Aleix Sala-Vila, Ella Haddad, Mercè Serra-Mir, Edward Bitok, Irene Roth, Tania M. Freitas-Simoes, Amandeep Kaur, Cinta Valls-Pedret, Mónica Doménech, Keiji Oda, Dolores Corella, Joan Sabaté, Emilio Ros
Journal: Circulation (2021)
Executive summary: Consensus recommendations for the use of retinoids in ichthyosis and other disorders of cornification in children and adolescents
Authors: Andrea L. Zaenglein, Moise L. Levy, Nicole S. Stefanko, Latanya T. Benjamin, Anna L. Bruckner, Keith Choate, Brittany G. Craiglow, John J. DiGiovanna, Lawrence F. Eichenfield, Peter Elias, Philip Fleckman, Leslie P. Lawley, Richard A. Lewis, Anne W. Lucky, Erin F. Mathes, Leonard M. Milstone, Amy S. Paller, Sonali S. Patel, Dawn H. Siegel, Joyce Teng, Sherry A. Tanumihardjo, Lauren Thaxton, Mary L. Williams
Journal: Journal of the American Academy of Dermatology (2021)
Evaluation of patches for rotator cuff repair: A systematic review and meta-analysis based on animal studies
Authors: Jinwei Yang, Yuhao Kang, Wanlu Zhao, Jia Jiang, Yanbiao Jiang, Bing Zhao, Mingyue Jiao, Bo Yuan, Jinzhong Zhao, Bin Ma
Journal: Bioactive Materials (2021)

Based on the published animal studies, we systematically evaluated the outcomes of various materials for rotator cuff repair in animal models and the potentials of their clinical translation. 74 animal studies were finally included, of which naturally derived biomaterials were applied the most widely (50.0%), rats were the most commonly used animal model (47.0%), and autologous tissue demonstrated the best outcomes in all animal models. The biomechanical properties of naturally derived biomaterials (maximum failure load: WMD 18.68 [95%CI 7.71-29.66]; P = 0.001, and stiffness: WMD 1.30 [95%CI 0.01-2.60]; P = 0.048) was statistically significant in the rabbit model. The rabbit model showed better outcomes even though the injury was severer compared with the rat model.
Spatial Stem Cell Fate Engineering via Facile Morphogen Localization
Authors: Gyuhyung Jin, Martha E. Floy, Aaron D. Simmons, Madeline M. Arthur, Sean P. Palecek
Journal: Advanced Healthcare Materials (2021)

Abstract Spatiotemporally controlled presentation of morphogens and elaborate modulation of signaling pathways elicit pattern formation during development. Though this process is critical for proper organogenesis, unraveling the mechanisms of developmental biology have been restricted by challenges associated with studying human embryos. Human pluripotent stem cells (hPSCs) have been used to model development in vitro, however difficulties in precise spatiotemporal control of the cellular microenvironment have limited the utility of this model in exploring mechanisms of pattern formation. Here, a simple and versatile method is presented to spatially pattern hPSC differentiation in 2‐dimensional culture via localized morphogen adsorption on substrates. Morphogens including bone morphogenetic protein 4 (BMP4), activin A, and WNT3a are patterned to induce localized mesendoderm, endoderm, cardiomyocyte (CM), and epicardial cell (EpiC) differentiation from hPSCs and hPSC‐derived progenitors. Patterned CM and EpiC co‐differentiation allows investigation of intercellular interactions in a spatially controlled manner and demonstrate improved alignment of CMs in proximity to EpiCs. This approach provides a platform for the controlled and systematic study of early pattern formation. Moreover, this study provides a facile approach to generate 2D patterned hPSC‐derived tissue structures for modeling disease and drug interactions.
Development of the alopecia areata scale for clinical use: Results of an academic–industry collaborative effort
Authors: Brett A. King, Natasha Atanaskova Mesinkovska, Brittany Craiglow, Chesahna Kindred, Justin Ko, Amy McMichael, Jerry Shapiro, Carolyn Goh, Paradi Mirmirani, Antonella Tosti, Maria Hordinsky, Kathie P. Huang, Leslie Castelo-Soccio, Wilma Bergfeld, Amy S. Paller, Julian Mackay-Wiggan, Marc Glashofer, Crystal Aguh, Melissa Piliang, Pedram Yazdan, Kristen Lo Sicco, James V. Cassella, Justine Koenigsberg, Gurpreet Ahluwalia, Eric Ghorayeb, Steven Fakharzadeh, Lynne Napatalung, Kavita Gandhi, Amy M. DeLozier, Fabio P. Nunes, Maryanne M. Senna
Journal: Journal of the American Academy of Dermatology (2021)

The current classification for alopecia areata (AA) does not provide a consistent assessment of disease severity.To develop an AA severity scale based on expert experience.A modified Delphi process was utilized. An advisory group of 22 AA clinical experts from the United States was formed to develop this AA scale. Representatives from the pharmaceutical industry provided feedback during its development.Survey responses were used to draft severity criteria, aspiring to develop a simple scale that may be easily applied in clinical practice. A consensus vote was held to determine the final AA severity statement, with all AA experts agreeing to adopt the proposed scale.The scale is a static assessment intended to be used in clinical practice and not clinical trials.The final AA disease severity scale, anchored in the extent of hair loss, captures key features commonly used by AA experts in clinical practice. This scale will better aid clinicians in appropriately assessing severity in patients with this common disease.
구연 : 카멜리아홀 ; 간세포암종과 MMP-1 유전자 단일염기 다형성과의 관련성
Authors: 장병국, 정강욱, 유경임, 정우진, 박경식, 조광범, 신동훈, 황재석
Journal: Clinical and Molecular Hepatology (2008)