tbuckley/cabot-search huggingface dataset:
Safety, immunogenicity, and transplacental antibody transport of conjugated and polysaccharide pneumococcal vaccines administered to pregnant women with HIV: a multicentre randomised controlled trial
Authors: Adriana Weinberg, Petronella Muresan, Lauren Laimon, Stephen I Pelton, David Goldblatt, Jennifer Canniff, Bonnie Zimmer, Frederic Bone, Lassallete Newton, Terence Fenton, James Kiely, Michael J Johnson, Esau C Joao, Breno R Santos, Elizabeth S Machado, Jorge A Pinto, Nahida Chakhtoura, Geraldo Duarte, Marisa M Mussi-Pinhata
Journal: The Lancet HIV (2021)
MEASUREMENT OF AORTIC PULSE WAVE VELOCITY IN PATIENTS WITH SUBCLINICAL OR CLINICAL HEART FAILURE WITH PRESERVED EJECTION FRACTION
Authors: Anum Asif, Michael Nelson, Chrisandra Shufelt, Galen Cook-Wiens, T. Jake Samuel, Nissi Suppogu, Judy Luu, Benita Tjoe, Balaji Tamarappoo, Daniel Berman, C.Noel Bairey Merz, Janet Wei
Journal: Journal of the American College of Cardiology (2021)
3D Printed Porous Methacrylate/Silica Hybrid Scaffold for Bone Substitution
Authors: Justin J. Chung, Jin Yoo, Brian S. T. Sum, Siwei Li, Soojin Lee, Tae Hee Kim, Zhenlun Li, Molly M. Stevens, Theoni K. Georgiou, Youngmee Jung, Julian R. Jones
Journal: Advanced Healthcare Materials (2021)

Inorganic-organic hybrid biomaterials made with star polymer poly(methyl methacrylate-co-3-(trimethoxysilyl)propyl methacrylate) and silica
Conjugated Polymer for Implantable Electronics toward Clinical Application
Authors: Yuxin Liu, Vivian Rachel Feig, Zhenan Bao
Journal: Advanced Healthcare Materials (2021)

Abstract Owing to their excellent mechanical flexibility, mixed‐conducting electrical property, and extraordinary chemical turnability, conjugated polymers have been demonstrated to be an ideal bioelectronic interface to deliver therapeutic effect in many different chronic diseases. This review article summarizes the latest advances in implantable electronics using conjugated polymers as electroactive materials and identifies remaining challenges and opportunities for developing electronic medicine. Examples of conjugated polymer‐based bioelectronic devices are selectively reviewed in human clinical studies or animal studies with the potential for clinical adoption. The unique properties of conjugated polymers are highlighted and exemplified as potential solutions to address the specific challenges in electronic medicine.
IMPACT OF CANNABIS USE ON HOSPITALIZATIONS FOR HYPERTENSIVE EMERGENCIES: A NATIONAL INPATIENT ANALYSIS, 2016-2017
Authors: Zainab Gandhi, Rupak Desai, Harsh P. Patel, Samarthkumar Thakkar, Sonali Sachdeva, Sandeep Singh, Gautam Kumar, Rajesh Sachdeva
Journal: Journal of the American College of Cardiology (2021)
Trends in Agricultural Triazole Fungicide Use in the United States, 1992–2016 and Possible Implications for Antifungal-Resistant Fungi in Human Disease
Authors: Mitsuru Toda, Karlyn D. Beer, Kathryn M. Kuivila, Tom M. Chiller, Brendan R. Jackson
Journal: Environmental Health Perspectives (2021)

Background: The fungus Aspergillus fumigatus (A. fumigatus) is the leading cause of invasive mold infections, which cause severe disease and death in immunocompromised people. Use of triazole antifungal medications in recent decades has improved patient survival; however, triazole-resistant infections have become common in parts of Europe and are emerging in the United States. Triazoles are also a class of fungicides used in plant agriculture, and certain triazole-resistant A. fumigatus strains found causing disease in humans have been linked to environmental fungicide use. Objectives: We examined U.S. temporal and geographic trends in the use of triazole fungicides using U.S. Geological Survey agricultural pesticide use estimates. Discussion: Based on our analysis, overall tonnage of triazole fungicide use nationwide was relatively constant during 1992–2005 but increased >4-fold during 2006–2016 to 2.9 million kg in 2016. During 1992–2005, triazole fungicide use occurred mostly in orchards and grapes, wheat, and other crops, but recent increases in use have occurred primarily in wheat, corn, soybeans, and other crops, particularly in Midwest and Southeast states. We conclude that, given the chemical similarities between triazole fungicides and triazole antifungal drugs used in human medicine, increased monitoring for environmental and clinical triazole resistance in A. fumigatus would improve overall understanding of these interactions, as well as help identify strategies to mitigate development and spread of resistance. https://doi.org/10.1289/EHP7484
Fedratinib Improves Myelofibrosis-related Symptoms and Health-related Quality of Life in Patients with Myelofibrosis Previously Treated with Ruxolitinib: Patient-reported Outcomes from the Phase II JAKARTA2 Trial
Authors: Claire N. Harrison, Nicolaas Schaap, Alessandro M. Vannucchi, Jean-Jacques Kiladjian, Eric Jourdan, Richard T. Silver, Harry C. Schouten, Francesco Passamonti, Sonja Zweegman, Moshe Talpaz, Srdan Verstovsek, Derek Tang, Pranav Abraham, Jennifer Lord-Bessen, Shelonitda Rose, Shien Guo, Weiqin Liao, Ruben A. Mesa
Journal: HemaSphere (2021)

Myelofibrosis symptoms compromise health-related quality of life (HRQoL). Ruxolitinib can reduce myelofibrosis symptom severity, but many patients discontinue ruxolitinib due to loss of response or unacceptable toxicity. Fedratinib is an oral, selective JAK2 inhibitor approved in the United States for treatment of patients with intermediate-2 or high-risk myelofibrosis. The single-arm, phase II JAKARTA2 trial assessed fedratinib 400 mg/d (starting dose) in patients with myelofibrosis previously treated with ruxolitinib. Patient-reported changes in myelofibrosis symptom severity using the modified Myelofibrosis Symptom Assessment Form (MFSAF), and overall HRQoL and functional status using the EORTC QLQ-C30, were evaluated at each cycle. Clinically meaningful changes from baseline HRQoL scores were based on effect sizes. Ninety patients were MFSAF-evaluable. Myelofibrosis symptoms were mild-to-moderate at baseline. Patients showed statistically significant and clinically meaningful improvements in total symptom scores from baseline on the MFSAF at all post baseline visits through the end of cycle 6 (EOC6). Baseline global health status/QoL and functional domain scores on the EORTC QLQ-C30 were meaningfully worse than in the general population. At EOC6, 44% of patients reported clinically meaningful improvements in global health status/QoL, and 30%–53% of patients experienced clinically meaningful improvement in QLQ-C30 functional domains across post baseline timepoints. Over 80% of ongoing patients perceived fedratinib as beneficial on the Patient’s Global Impression of Change questionnaire. Fedratinib effects were consistent among prognostically relevant patient subgroups. Patients with myelofibrosis previously treated with ruxolitinib experienced clinically meaningful improvements in myelofibrosis symptom burden, overall HRQoL, and functional status in the first 6 months of fedratinib treatment.
NOVEL PREDICTIVE MODEL FOR LEAFLET THROMBOSIS IN TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Hoda Hatoum, Shelly Singh-Gryzbon, Philipp Ruile, Franz-Josef Neumann, Philipp Blanke, Vinod Thourani, Ajit Yoganathan, Lakshmi Prasad Dasi
Journal: Journal of the American College of Cardiology (2021)
INCREMENTAL INTRACORONARY ACETYLCHOLINE FOR CORONARY ENDOTHELIAL AND VASOSPASM TESTING: A REPORT FROM THE WOMEN’S ISCHEMIA SYNDROME EVALUATION-CORONARY VASCULAR DYSFUNCTION (WISE-CVD) CONTINUATION PROJECT
Authors: Benita Tjoe, C. Noel Bairey Merz, Chrisandra Shufelt, Nissi Suppogu, Judy Luu, Anum Asif, Galen Cook-Wiens, Bruce Samuels, Babak Azarbal, John Petersen, R. David Anderson, Eileen Handberg, Carl Pepine, Janet Wei
Journal: Journal of the American College of Cardiology (2021)
Correction to: HLA-A2.1-restricted ECM1-derived epitope LA through DC cross-activation priming CD8+ T and NK cells: a novel therapeutic tumour vaccine
Authors: Zhaojin Yu, Wensi Liu, Ying He, Mingli Sun, Jiankun Yu, Xue Jiao, Qiang Han, Haichao Tang, Bing Zhang, Yunkai Xian, Jing Qi, Jing Gong, Wang Xin, Gang Shi, Fengping Shan, Rui Zhang, Jianping Li, Minjie Wei
Journal: Journal of Hematology & Oncology (2021)

The original article [1] contains errors in Figure 3i, Figure 6c and Figure S9: 1.In Fig. 3i, the legends of the line chart were marked incorrectly.2. In Fig. 6c, the panel of ISA CD8a + group was unintentionally duplicated onto the panel of YL-ISA NK1.1 + group.3. In Figure S9, the panel of LA-ISA Liver group was misused.
COMPARING RADIAL AND FEMORAL APPROACHES IN PATIENTS WITH SEVERE AORTIC STENOSIS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION PRIOR TO TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Salman Farhat, Abdallah El Sabbagh, Mohammed Al-Hijji, Keniel Pierre, Rayan Suliman, Yader Sandoval, S. Gharacholou, Peter Pollak, Malcolm Bell, Rajiv Gulati, Mandeep Singh, Mackram Eleid, Mohammed Al-Khouli, David Holmes, Mayra Guerrero, Charanjit Rihal
Journal: Journal of the American College of Cardiology (2021)
LP(A) DISTRIBUTION AND CORRELATION WITH LDL-C IN PATIENTS WITH ATHEROSCLEROTIC CARDIOVASCULAR DISEASE (ASCVD) IN THE US
Authors: Raquel Lahoz, Andres Laguna, Philippe Ferber, Rachel Studer, Joaquim Cristino, Jihaeng Heo, Yingjie Ding, Ana Filipa Fonseca
Journal: Journal of the American College of Cardiology (2021)
OUTCOMES OF SECUNDUM ATRIAL SEPTAL DEFECT CLOSURE WITH THE NEW GORE CARDIOFORM ASD OCCLUDER- RESULTS FROM THE CONTINUED ACCESS GORE ASSURED CLINICAL TRIAL
Authors: Athar M. Qureshi, Robert Sommer, Gareth Morgan, Robert Gray, Barry Love, Bryan Goldstein, Lissa Sugeng, Matthew Gillespie
Journal: Journal of the American College of Cardiology (2021)
I SPY: USING MULTIMODALITY IMAGING TO DIFFERENTIATE AN APICAL LEFT VENTRICULAR (LV) THROMBUS FROM MYOCARDIAL SCAR
Authors: Zahra Khaled, Adnan Yousaf, Enrique Soltero Mariscal, Ahmad Jabri, Meera Kondapaneni, Ashish Aneja
Journal: Journal of the American College of Cardiology (2021)
CLINICAL EVENT REDUCTIONS IN HIGH-RISK HYPERTENSION PATIENTS TREATED WITH RENAL DENERVATION: A MODEL-BASED ESTIMATE BASED ON 36-MONTH DATA FROM THE GLOBAL SYMPLICITY REGISTRY
Authors: Jan Pietzsch, Felix Mahfoud, Bryan Williams, Giuseppe Mancia, Krzysztof Narkiewicz, Luis Ruilope, Markus Schlaich, Douglas Hettrick, Michael Boehm, Roland Schmieder
Journal: Journal of the American College of Cardiology (2021)
Bone Marrow Mesenchymal Stromal Cell-mediated Resistance in Multiple Myeloma Against NK Cells can be Overcome by Introduction of CD38-CAR or TRAIL-variant
Authors: Lisa C. Holthof, Arwen Stikvoort, Hilma J. van der Horst, Anne T. Gelderloos, Renée Poels, Fengzhi Li, Richard W. J. Groen, Sonja Zweegman, Niels W. C. J. van de Donk, Michael O’Dwyer, Tuna Mutis
Journal: HemaSphere (2021)

We have recently shown the strong negative impact of multiple myeloma (MM)-bone marrow mesenchymal stromal cell (BMMSC) interactions to several immunotherapeutic strategies including conventional T cells, chimeric antigen receptor (CAR) T cells, and daratumumab-redirected NK cells. This BMMSC-mediated immune resistance via the upregulation of antiapoptotic proteins in MM cells was mainly observed for moderately cytotoxic modalities. Here, we set out to assess the hypothesis that this distinct mode of immune evasion can be overcome by improving the overall efficacy of immune effector cells. Using an in vitro model, we aimed to improve the cytotoxic potential of KHYG-1 NK cells toward MM cells by the introduction of a CD38-specific CAR and a DR5-specific, optimized TRAIL-variant. Similar to what have been observed for T cells and moderately lytic CAR T cells, the cytolytic efficacy of unmodified KHYG-1 cells as well as of conventional, DR5-agonistic antibodies were strongly reduced in the presence of BMMSCs. Consistent with our earlier findings, the BMMSCs protected MM cells against KHYG-1 and DR5-agonistic antibodies by inducing resistance mechanisms that were largely abrogated by the small molecule FL118, an inhibitor of multiple antiapoptotic proteins including Survivin, Mcl-1, and XIAP. Importantly, the BMMSC-mediated immune resistance was also significantly diminished by engineering KHYG-1 cells to express the CD38-CAR or the TRAIL-variant. These results emphasize the critical effects of microenvironment-mediated immune resistance on the efficacy of immunotherapy and underscores that this mode of immune escape can be tackled by inhibition of key antiapoptotic molecules or by increasing the overall efficacy of immune killer cells.
KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease
Authors: Yutaro Mori, Amrendra K. Ajay, Jae-Hyung Chang, Shan Mou, Huiping Zhao, Seiji Kishi, Jiahua Li, Craig R. Brooks, Sheng Xiao, Heung-Myong Woo, Venkata S. Sabbisetti, Suetonia C. Palmer, Pierre Galichon, Li Li, Joel M. Henderson, Vijay K. Kuchroo, Julie Hawkins, Takaharu Ichimura, Joseph V. Bonventre
Journal: Cell Metabolism (2021)
THIRTY-DAY READMISSION RISK IN PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION WHO RECEIVED A PALLIATIVE CARE CONSULT DURING HOSPITALIZATION COMPARED WITH THOSE WHO DID NOT RECEIVE A PALLIATIVE CARE CONSULT - AN INSIGHT FROM A NATIONWIDE DATABASE
Authors: Radhika Deshpande, Yasser Al-Khadra, Prashanth Singanallur, Basma Al-bast, Venkata Missula, Nour Albast, Manasik Abdu, Raad Al Tamimi, Abhishek Kulkarni, Kalyan Potu
Journal: Journal of the American College of Cardiology (2021)
Cannabinoids and Immune Function--Reply
Authors: R. Pacifici
Journal: JAMA (2003)

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Profiling B cell immunodominance after SARS-CoV-2 infection reveals antibody evolution to non-neutralizing viral targets
Authors: Haley L. Dugan, Christopher T. Stamper, Lei Li, Siriruk Changrob, Nicholas W. Asby, Peter J. Halfmann, Nai-Ying Zheng, Min Huang, Dustin G. Shaw, Mari S. Cobb, Steven A. Erickson, Jenna J. Guthmiller, Olivia Stovicek, Jiaolong Wang, Emma S. Winkler, Maria Lucia Madariaga, Kumaran Shanmugarajah, Maud O. Jansen, Fatima Amanat, Isabelle Stewart, Henry A. Utset, Jun Huang, Christopher A. Nelson, Ya-Nan Dai, Paige D. Hall, Robert P. Jedrzejczak, Andrzej Joachimiak, Florian Krammer, Michael S. Diamond, Daved H. Fremont, Yoshihiro Kawaoka, Patrick C. Wilson
Journal: Immunity (2021)
CHARACTERISTICS AND OUTCOMES OF ATRIAL FIBRILLATION IN CARDIAC SARCOIDOSIS
Authors: Erika Hutt, Maria Vega Brizneda, Jose Aguilera, Ziad Taimeh, Manuel Ribeiro, Daniel Culver, Ayman Hussein, Thomas Callahan, Oussama Wazni, Paul Cremer, Wael Jaber, Christine Jellis
Journal: Journal of the American College of Cardiology (2021)
Huntington’s disease mice and human brain tissue exhibit increased G3BP1 granules and TDP43 mislocalization
Authors: Isabella I. Sanchez, Thai B. Nguyen, Whitney E. England, Ryan G. Lim, Anthony Q. Vu, Ricardo Miramontes, Lauren M. Byrne, Sebastian Markmiller, Alice L. Lau, Iliana Orellana, Maurice A. Curtis, Richard Lewis Maxwell Faull, Gene W. Yeo, Christie D. Fowler, Jack C. Reidling, Edward J. Wild, Robert C. Spitale, Leslie M. Thompson
Journal: Journal of Clinical Investigation (2021)

Chronic cellular stress associated with neurodegenerative disease can result in the persistence of stress granule (SG) structures, membraneless organelles that form in response to cellular stress. In Huntington's disease (HD), chronic expression of mutant huntingtin generates various forms of cellular stress, including activation of the unfolded protein response and oxidative stress. However, it has yet to be determined whether SGs are a feature of HD neuropathology. We examined the miRNA composition of extracellular vesicles (EVs) present in the cerebrospinal fluid (CSF) of patients with HD and show that a subset of their target mRNAs were differentially expressed in the prefrontal cortex. Of these targets, SG components were enriched, including the SG-nucleating Ras GTPase-activating protein-binding protein 1 (G3BP1). We investigated localization and levels of G3BP1 and found a significant increase in the density of G3BP1-positive granules in the cortex and hippocampus of R6/2 transgenic mice and in the superior frontal cortex of the brains of patients with HD. Intriguingly, we also observed that the SG-associated TAR DNA-binding protein 43 (TDP43), a nuclear RNA/DNA binding protein, was mislocalized to the cytoplasm of G3BP1 granule–positive HD cortical neurons. These findings suggest that G3BP1 SG dynamics may play a role in the pathophysiology of HD.
Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts
Authors: Sonakshi Bhattacharjee, Florian Hamberger, Aashreya Ravichandra, Maximilian Miller, Ajay Nair, Silvia Affo, Aveline Filliol, LiKang Chin, Thomas M Savage, Deqi Yin, Naita Maren Wirsik, Adam Mehal, Nicholas Arpaia, Ekihiro Seki, Matthias Mack, Di Zhu, Peter A Sims, Raghu Kalluri, Ben Z Stanger, Kenneth P Olive, Thomas Schmidt, Rebecca G Wells, Ingmar Mederacke, Robert F Schwabe
Journal: Journal of Clinical Investigation (2021)

Cancer-associated fibroblasts (CAF) may exert tumor-promoting and tumor-suppressive functions, but the mechanisms underlying these opposing effects remain elusive. Here, we sought to understand these potentially opposing functions by interrogating functional relationships among CAF subtypes, their mediators, desmoplasia, and tumor growth in a wide range of tumor types metastasizing to the liver, the most common organ site for metastasis. Depletion of hepatic stellate cells (HSC), which represented the main source of CAF in mice and patients in our study, or depletion of all CAF decreased tumor growth and mortality in desmoplastic colorectal and pancreatic metastasis but not in nondesmoplastic metastatic tumors. Single-cell RNA-Seq in conjunction with CellPhoneDB ligand-receptor analysis, as well as studies in immune cell–depleted and HSC-selective knockout mice, uncovered direct CAF-tumor interactions as a tumor-promoting mechanism, mediated by myofibroblastic CAF–secreted (myCAF-secreted) hyaluronan and inflammatory CAF–secreted (iCAF-secreted) HGF. These effects were opposed by myCAF-expressed type I collagen, which suppressed tumor growth by mechanically restraining tumor spread, overriding its own stiffness-induced mechanosignals. In summary, mechanical restriction by type I collagen opposes the overall tumor-promoting effects of CAF, thus providing a mechanistic explanation for their dual functions in cancer. Therapeutic targeting of tumor-promoting CAF mediators while preserving type I collagen may convert CAF from tumor promoting to tumor restricting.
CHARACTERISTIC FINDINGS OF MICROVASCULAR DYSFUNCTION ON CORONARY COMPUTED TOMOGRAPHY ANGIOGRAPHY IN PATIENTS WITH INTERMEDIATE CORONARY STENOSIS
Authors: Masahiro Hoshino, Tomoyo Sugiyama, Yoshihisa Kanaji, Masao Yamaguchi, Masahiro Hada, Toru Misawa, Tatsuhiro Nagamine, Kai Nogami, Yumi Yasui, Taishi Yonetsu, Tetsuo Sasano, Tsunekazu Kakuta
Journal: Journal of the American College of Cardiology (2021)
Phosphatidylserine-exposing tumor-derived microparticles exacerbate coagulation and cancer cell transendothelial migration in triple-negative breast cancer
Authors: Cong Zhang, Zhuowen Yang, Peng Zhou, Muxin Yu, Baorong Li, Yingmiao Liu, Jiaqi Jin, Wenhui Liu, Haijiao Jing, Jingwen Du, Jie Tian, Zhiyu Zhao, Jianxin Wang, Yinzhu Chu, ChunMei Zhang, Valerie A Novakovic, Jialan Shi, Changjun Wu
Journal: Theranostics (2021)

Neoadjuvant chemotherapy is relevant to the formation of thromboembolism and secondary neoplasms in triple-negative breast cancer (TNBC). Chemotherapy-induced breast cancer cell-derived microparticles (BCMPs) may have important thrombogenic and pro-metastatic effects on platelets and endothelium, which may be related to the expression and distribution of phosphatidylserine (PS). However, investigating these interactions is challenging due to technical limitations.
Audio Interview: Advice for Clinicians on Covid-19 Vaccines and Social Restrictions
Authors: Eric J. Rubin, Lindsey R. Baden, Stephen Morrissey
Journal: New England Journal of Medicine (2021)

Advice for Clinicians on Covid-19 Vaccines and Social Restrictions In this audio interview conducted on April 27, 2021, the editors discuss advising patients on Covid-19 vaccination and on the loos...
Platelet Function in CKD: A Systematic Review and Meta-Analysis
Authors: Constance C.F.M.J. Baaten, Marieke Sternkopf, Tobias Henning, Nikolaus Marx, Joachim Jankowski, Heidi Noels
Journal: Journal of the American Society of Nephrology (2021)

Patients with CKD are at high risk for thrombotic and hemorrhagic complications. Abnormalities in platelet function are central to these complications, but reports on platelet function in relation to CKD are conflicting, and vary from decreased platelet reactivity to normal or increased platelet responsiveness. The direct effects of uremic toxins on platelet function have been described, with variable findings.To help clarify how CKD affects platelet function, we conducted a systematic review and meta-analysis of platelet activity in CKD, with a focus on nondialysis-induced effects. We also performed an extensive literature search for the effects of individual uremic toxins on platelet function.We included 73 studies in the systematic review to assess CKD's overall effect on platelet function in patients; 11 of them described CKD's effect on ex vivo platelet aggregation and were included in the meta-analysis. Although findings on platelet abnormalities in CKD are inconsistent, bleeding time was mostly prolonged and platelet adhesion mainly reduced. Also, the meta-analysis revealed maximal platelet aggregation was significantly reduced in patients with CKD upon collagen stimulation. We also found that relatively few uremic toxins have been examined for direct effects on platelets ex vivo; ex vivo analyses had varying methods and results, revealing both platelet-stimulatory and inhibitory effects. However, eight of the 12 uremic toxins tested in animal models mostly induced prothrombotic effects.Overall, most studies report impaired function of platelets from patients with CKD. Still, a substantial number of studies find platelet function to be unchanged or even enhanced. Further investigation of platelet reactivity in CKD, especially during different CKD stages, is warranted.
MICRA PACEMAKER, MACRO COMPLICATION. FIRST REPORTED CASE OF CORONARY CAMERAL FISTULA CAUSED BY LEADLESS PACEMAKER IMPLANT
Authors: Vy Nguyen, Marc Iskandar, Christopher Foth, Hans Rutzen-Lopez, Marquand Patton, Raul Alonso
Journal: Journal of the American College of Cardiology (2021)