tbuckley/cabot-search huggingface dataset:
Trial of Intensive Blood-Pressure Control in Older Patients with Hypertension
Authors: Hans-Michael Steffen, Gerd Bönner, Martin Middeke
Journal: New England Journal of Medicine (2021)

it is likely that these two conditions will remain difficult to separate, we plan further analyses to explore these possibilities.Withdrawal symptoms can only occur in the discontinuation group, but participants reported some new and worsening symptoms while continuing to take antidepressants.We found no evidence that the hazard ratio for relapse varied across the 12-month follow-up period, whereas one would expect withdrawal symptoms to cluster around the time after the medication was terminated.We found that the difference in withdrawal symptoms between the groups was largest at 12 weeks.Kuschpel inquires about the severity of relapses in our trial.In addition to our prespecified definition of relapse, we used internationally agreed-upon International Classification of Diseases, version 10, criteria for relapse of depression and found similar results to those in our primary analysis (see Table S11 in the Supplementary Appendix, available with the full text of our article at NEJM.org).We recorded relapses that may have occurred at any time in the 3 months preceding the assessment and may have resolved by the time the participant was assessed on our secondary outcomes, such as the PHQ-9.We therefore would have expected a smaller betweengroup difference regarding secondary outcomes because they only assessed how the participant was feeling at the time of the assessment.Our finding that people in the discontinuation group were more likely to guess their allocation could be due to the clinical effect of discontinuation and is not, in our view, an indication that our findings were invalid.
Incidental Finding of Testicular Seminoma by 18F-Choline PET/CT in a Prostate Cancer Patient
Authors: Anna Calabrò, Giovanni Bosio, Emma Drera, Raffaele Giubbini, Francesco Bertagna
Journal: Clinical Nuclear Medicine (2022)

Abstract An 80-year-old man with a history of prostate cancer, treated with radical prostatectomy and bilateral obturator nodal dissection, underwent an 18 F-choline PET/CT because of biochemical recurrence. The scan revealed an intense focal uptake in the right testicle. A subsequent orchifunicumlectomy demonstrated the presence of a classic seminoma. At present, 18 F-FDG PET/CT is useful for initial staging of testicular cancer and determining the viability of residual masses &gt;3 cm after completion of treatment, especially in patients with seminoma.
Patient-Centered Palliative Care for Patients With Advanced Lung Cancer
Authors: Jennifer S. Temel, Laura A. Petrillo, Joseph A. Greer
Journal: Journal of Clinical Oncology (2022)

The evidence base demonstrating the benefits of an early focus on palliative care for patients with serious cancers, including advanced lung cancer, is substantial. Early involvement of specialty-trained palliative care clinicians in the care of patients with advanced lung cancer improves patient-reported outcomes, such as quality of life, and health care delivery, including hospice utilization. Since the time that many of these palliative care trials were conducted, the paradigm of cancer care for many cancers, including lung cancer, has changed dramatically. The majority of patients with advanced lung cancer are now treated with immune checkpoint inhibitors or targeted therapies, both of which have had a significant impact on patient's experience and outcomes. With this changing landscape of lung cancer therapeutics, patients are facing new and different challenges, including dealing with novel side effect profiles and coping with greater uncertainty regarding their prognosis. Patients who are living longer with their advanced cancer also struggle with how to address survivorship issues, such as sexual health and exercise, and decision making about end-of-life care. Although palliative care clinicians remain well-suited to address these care needs, they may need to learn new skills to support patients treated with novel therapies. Additionally, as the experience of patients with advanced lung cancer is becoming more varied and individualized, palliative care research interventions and clinical programs should also be delivered in a patient-centered manner to best meet patient's needs and improve their outcomes. Tailored and technology-based palliative care interventions are promising strategies for delivering patient-centered palliative care.
BUST OF THE LATE PROFESSOR WILLIAM H. BYFORD.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cholangiocarcinoma progression depends on the uptake and metabolization of extracellular lipids
Authors: Mikel Ruiz de Gauna, Francesca Biancaniello, Francisco González‐Romero, Pedro M. Rodrigues, Ainhoa Lapitz, Beatriz Gómez‐Santos, Paula Olaizola, Sabina Di Matteo, Igor Aurrekoetxea, Ibone Labiano, Ane Nieva‐Zuluaga, Asier Benito‐Vicente, María J. Perugorria, Maider Apodaka‐Biguri, Nuno A. Paiva, Diego Sáenz de Urturi, Xabier Buqué, Igotz Delgado, César Martín, Mikel Azkargorta, Felix Elortza, Diego F. Calvisi, Jesper B. Andersen, Domenico Alvaro, Vincenzo Cardinale, Luis Bujanda, Jesús M. Banales, Patricia Aspichueta
Journal: Hepatology (2022)

Cholangiocarcinoma (CCA) includes a heterogeneous group of biliary cancers with a dismal prognosis. We investigated if lipid metabolism is disrupted in CCA and its role in tumor proliferation.The in vitro and in vivo tumorigenic capacity of five human CCA cell lines was analyzed. Proteome, lipid content, and metabolic fluxes were evaluated in CCA cells and compared with normal human cholangiocytes (NHC). The Akt1/NOTCH1 intracellular cytoplasmic domain (Nicd1)-driven CCA mouse model was also evaluated. The proteome of CCA cells was enriched in pathways involved in lipid and lipoprotein metabolism. The EGI1 CCA cell line presented the highest tumorigenic capacity. Metabolic studies in high (EGI1) versus low (HUCCT1) proliferative CCA cells in vitro showed that both EGI1 and HUCCT1 incorporated more fatty acids (FA) than NHC, leading to increased triglyceride storage, also observed in Akt1/Nicd1-driven CCA mouse model. The highly proliferative EGI1 CCA cells showed greater uptake of very-low-density and HDLs than NHC and HUCCT1 CCA cells and increased cholesteryl ester content. The FA oxidation (FAO) and related proteome enrichment were specifically up-regulated in EGI1, and consequently, pharmacological blockade of FAO induced more pronounced inhibition of their tumorigenic capacity compared with HUCCT1. The expression of acyl-CoA dehydrogenase ACADM, the first enzyme involved in FAO, was increased in human CCA tissues and correlated with the proliferation marker PCNA.Highly proliferative human CCA cells rely on lipid and lipoprotein uptake to fuel FA catabolism, suggesting that inhibition of FAO and/or lipid uptake could represent a therapeutic strategy for this CCA subclass.
Non-typeable Haemophilus influenzae–Moraxella catarrhalis vaccine for the prevention of exacerbations in chronic obstructive pulmonary disease: a multicentre, randomised, placebo-controlled, observer-blinded, proof-of-concept, phase 2b trial
Authors: Stefan Andreas, Marco Testa, Laurent Boyer, Guy Brusselle, Wim Janssens, Edward Kerwin, Alberto Papi, Bonavuth Pek, Luis Puente-Maestu, Dinesh Saralaya, Henrik Watz, Tom M A Wilkinson, Daniela Casula, Gennaro Di Maro, Maria Lattanzi, Luca Moraschini, Sonia Schoonbroodt, Annaelisa Tasciotti, Ashwani K Arora, François Maltais, Guy Brusselle, Jean-Louis Corhay, Eduard Janssens, Wim Janssens, Mathias Leys, Murdo Ferguson, Mark Fitzgerald, François Maltais, Irvin Mayers, Shelly McNeil, Bonavuth Pek, Arnaud Bourdin, Laurent Boyer, Francis Couturaud, Luc Dussart, Stefan Andreas, Gabriele Illies, Andreas Eich, Andrea Ludwig-Sengpiel, Henrik Watz, Francesco Blasi, Stefano Centanni, Alberto Papi, Carlo Pomari, José Maria Echave-Sustaeta, Eleuterio Llorca Martínez, Silvia Narejos Pérez, Sergi Pascual-Guardia, Mercè Pérez Vera, Luis Puente-Maestu, Manuel Terns Riera, William Anderson, Gourab Choudhury, Anthony De-Soyza, Dinesh Saralaya, Tom MA Wilkinson, Joseph Boscia III, Kenneth Chinsky, Leonard Dunn, David Erb, Charles Fogarty, Herman Jackson Downey, Edward Kerwin, Craig Kunz, Terry Poling, Richard Sellman, Barry Sigal, John Southard, Selwyn Spangenthal, Ziad Tannous, Marco Testa, Daniela Casula, Gennaro Di Maro, Maria Lattanzi, Luca Moraschini, Sonia Schoonbroodt, Annaelisa Tasciotti, Ashwani K Arora
Journal: The Lancet Respiratory Medicine (2022)
BOOK REVIEWS
Authors: NAGI F. KHOURI
Journal: JNCI Journal of the National Cancer Institute (1992)

BOOK REVIEWS Film-Screen Mammography: An Atlas of Instructional Cases Lawrence W. Bassett , Reza Jahanshahi , Richard H. Gold , Yao S. Fu . New York : Raven Press , 1991 . 312 pp., illus. $130 NAGI F. KHOURI NAGI F. KHOURI Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 6, 18 March 1992, Page 447, https://doi.org/10.1093/jnci/84.6.447 Published: 18 March 1992
Table of Contents
Authors: Sébastien Gendarme, Christos Chouaid, Mariusz Adamek, Wojciech Biernat, Joanna Chorostowska-Wynimko, Joanna Didkowska, Katarzyna Dziadziuszko, Tomasz Grodzki, Jacek Jassem, Lucyna Kępka, Dariusz Kowalski, Paweł Krawczyk, Maciej Krzakowski, Jacek Nikli Nski, Renata Langfort, Włodzimierz Olszewski, Tadeusz Orłowski, Rodryg Ramlau, Witold Rzyman, Anna Wrona, Marcin Zieli Nski, Rafał Dziadziuszko, Ming-Wen An, Quyen Duong, Jennifer Le-Rademacher, Sumithra Mandrekar, Dipesh Uprety, Dennis Wigle, Anja Roden, Alex Adjei, Mark Hammer, Lauren Palazzo, Adelle Paquette, Andrew Eckel, Francine Jacobson, Eduardo Barbosa, Chung Kong
Journal: Journal of Thoracic Oncology (2020)
The ACT Accelerator: heading in the right direction?
Authors: None The Lancet
Journal: The Lancet (2021)

April 24, 2021, marks 1 year since the formation of the Access to COVID-19 Tools Accelerator (ACT-A) partnership. Its mission is to accelerate the development, production, and equitable access to COVID-19 tests, treatments, and vaccines, which is central to ending the acute phase of the COVID-19 pandemic. With the pandemic still raging, has ACT-A been successful so far? And what does the future hold?
Annals Graphic Medicine - The Endless Battle
Authors: Emily S. Yin
Journal: Annals of Internal Medicine (2022)

Web ExclusivesJanuary 2022Annals Graphic Medicine - The Endless BattleFREEEmily S. Yin, MD, MHSEmily S. Yin, MD, MHSNYU Langone Health, New York, New York (E.S.Y.).Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/G21-0025 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Download figure Download PowerPoint Comments0 CommentsSign In to Submit A Comment Kyle Krohn, MDNone10 January 2022 Right on target Absolutely dead-on perfect. Author, Article, and Disclosure InformationAffiliations: NYU Langone Health, New York, New York (E.S.Y.).Disclosures: The author has reported no disclosures of interest. The form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=G21-0025.Author/Illustrator Information: Emily S. Yin, MD, MHS, is a dermatology resident at NYU Grossman School of Medicine (e-mail, emily.s.[email protected]com). You can view more of her work on Instagram (www.instagram.com/dremilyyin).This article was published at Annals.org on 11 January 2022. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics January 2022Volume 175, Issue 1Page: W12-W13 ePublished: 11 January 2022 Issue Published: January 2022 Copyright & PermissionsCopyright © 2022 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Political commitment to MERS-CoV in Saudi Arabia
Authors: None The Lancet
Journal: The Lancet (2014)

On April 27, Saudi Arabia reported 16 new cases of infection by the Middle East respiratory syndrome coronavirus (MERS-CoV). Worldwide, from September, 2012, to April 26, 2014, WHO has reported 261 laboratory-confirmed infections, including 93 deaths. According to Nick Phin of Public Health England, and academics involved in the Global Centre for Mass Gatherings Medicine, the recent apparent rise in MERS-CoV infections in Saudi Arabia could have resulted from various factors, including seasonality, increased proactive screening, and poor infection control measures.
Fundamentals of magnetic resonance imaging. Council on Scientific Affairs
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fatal Amphetamine Poisoning
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Observations
Authors: J. R. Cormack
Journal: BMJ (1849)

CLINICAL OBSERVATIONS.rianic acid, will be found serviceable in cases associated with hysterical symptoms, such as the globus hystericus, and other spasmodic affec- tions.'After a time,.chalybeates will be advantageously replaced, for a short period, by vegetable tonics and mineral acids.The most suit- alle of tfhese, to alternate with the preparations of iron, are, in my opinion, the decoction of cinchona in combination with dilute sulphuric acid,-far more efficacious than sulphate of quinine; the infusion of gentian with this acid, or the hydrochloric; tannin, in doses of half a grain, dissolved in infusion of gentian and combined with nitric acid, a most efficient roborant combination, in this and many other diseases, including phthisis; pulmonalis.These vegetable tonics and mineral acids will likewise be found well adapted to cases of Goitre, associated with general debility, independent of animia.In such examples, requiring cordial treatment, the tinct- ures should be employed in preference to infusions; and when a nervine or composer is required, the tincture of hops will prove highly advan- tageous, either with or without the aromatic spirits of ammonia, as circumstances may indicate.The regimen most suitable for cases of Goitre is well known, and therefore may be dismissed in a few words.It should embrace a substantial diet, regularity, and exercise in the open air.The place of residence, if infested with the disease, should be changed, if possible, for a locality with a dry soil, open country, and a pure invigorating atmosphere.
Association Between Maternal Hormonal Contraception Use and Central Nervous System Tumors in Children
Authors: Marie Hargreave, Lina S. Mørch, Jeanette F. Winther, Kjeld Schmiegelow, Susanne K. Kjaer
Journal: JAMA (2022)

<h3>Importance</h3> The incidence of central nervous system (CNS) tumors in children appears to be increasing, yet few risk factors are established. There is limited information regarding whether maternal hormonal contraception use increases this risk. <h3>Objective</h3> To examine the association between maternal hormonal contraception use and CNS tumors in children (&lt;20 years). <h3>Design, Setting, and Participants</h3> In this nationwide cohort study based on population-based registry data, 1 185 063 children born in Denmark between January 1, 1996, and December 31, 2014, were followed up for a diagnosis of a CNS tumor (final follow-up on December 31, 2018). <h3>Exposures</h3> Maternal hormonal contraception use was analyzed according to any use, regimen (combined/progestin only), and route of administration (oral/nonoral), categorized as recent use (≤3 months before start and during pregnancy), previous use (&gt;3 months before start of pregnancy), and no use. For injections, implants, and intrauterine devices that are used for a different time period, the categorization was appropriately altered. <h3>Main Outcomes and Measures</h3> Hazard ratio (HR) and incidence rate difference (IRD) of CNS tumors diagnosed at younger than 20 years. <h3>Results</h3> After 15 335 990 person-years of follow-up (mean follow-up, 12.9 years), 725 children were diagnosed with a CNS tumor. The mean age at diagnosis was 7 years, and 342 (47.2%) of the diagnosed children were female. The adjusted incidence rate of CNS tumors per 100 000 person-years was 5.0 for children born to mothers with recent hormonal contraception use (n = 136 022), 4.5 for children born to mothers with previous use (n = 778 843), and 5.3 for children born to mothers with no use (n = 270 198). The corresponding HRs were 0.95 ([95% CI, 0.74-1.23]; 84 children with CNS tumors; IRD, −0.3 [95% CI, −1.6 to 1.0]) for recent use and 0.86 ([95% CI, 0.72-1.02]; 421 children with CNS tumors; IRD, −0.8 [95% CI, −1.7 to 0.0]) for previous use, compared with no use. No statistically significant associations were found for recent or previous use of oral combined, nonoral combined, oral progestin only, or nonoral products compared with no use of hormonal contraception. <h3>Conclusions and Relevance</h3> Among Danish children, there was no statistically significant association between any maternal hormonal contraception use and CNS tumor risk.
Focal FDG Uptake in the Cerebral Parenchyma Beneath the Subdural Hematoma
Authors: Mingyuan Liu, Haibo Wu, Lili Shan, Aisheng Dong, Yan Han
Journal: Clinical Nuclear Medicine (2022)

Abstract Changes in cerebral glucose metabolism after subdural hematoma have been rarely reported. We present a case with acute subdural hematoma detected unexpectedly on FDG PET/CT. Focal intense FDG uptake in the cerebral parenchyma beneath the subdural hematoma was seen on PET. The density of the cerebral parenchyma was normal on CT. The patient received conservative management. He recovered without any complication. This case indicates that familiarity with the changes in cerebral glucose metabolism on PET after subdural hematoma may be helpful for optimal patient care.
Error in Additional Contributions
Authors: Ezra Golberstein
Journal: JAMA Pediatrics (2020)

The Research Letter titled "Prevalence of SARS-CoV-2 Infection in Children Without Symptoms of Coronavirus Disease 2019," 1 published online August 25, 2020, contained errors in Figure 1.The labels for 1.0 and 1.5 on the y-axis of the forest plot graph were reversed.Also, the square indicating the prevalence for site 14 was displaced from its true value, 2.21%, to approximately 2.75%; this square was also larger than it should have been.The errors have been corrected.
Apolipoprotein (a) isoform size is not the only determinant of plasma lipoprotein(a) level in the elderly: Data from the prospective study of pravastatin in the elderly at risk: PROSPER Allan Gaw, Elizabeth A. Brown, John Norrie, PROSPER Executive. Glasgow Royal Infirmary, Glasgow, United Kingdom, University of Glasgow, Glasgow, United Kingdom
Journal: Journal of the American College of Cardiology (2001)
I. <i>Le Progrès de la Reforma du Traitement des Aliénés en France</i>. Par le Dr. Victor Parant. (The Progress of Reform in the Treatment of the insane in France)
Authors: H. M. B.
Journal: American Journal of Psychiatry (1894)

The symptoms of the specific disorder preceding progressive paralysis are commonly relatively mild. 5.In comparison with syphilis, imereditary predisposition, psychic causes, alcoholic excesses, sexual excesses, and traumatisnm, lmave only a subordinate part in producing paresis.6.Of time different forms of the disorder the maniacal type was most frequent, next the demented, and lastly the melancholic.7. Time prognosis is unfavorable.Time duration of the disease was under four years in 82.9 per cent., and umnder two years in 43.6 per cent.Remissions occur.8.In cases preceded by syphilis there are no symptoms specially characteristic of specific disease.9.No imnprovement was observed from auto-syphilitic treatmmment.10.At the autopsy no appearances of specially specific cimaracter were found.
Is initial antegrade flow same to early reperfusion in patients with acute myocardial infarction? Masaharu Ishihara, Hikaru Sato, Takuji Kawagoe, Yuji Shimatani, Satoshi Kurisu, Kenji Nishioka, Yasuyuki Kouno, Takashi Umemura, Shuji Nakamura. Hiroshima City Hospital, Hiroshima, Japan
Journal: Journal of the American College of Cardiology (2001)