Delayed skin cancer diagnosis in 2020 because of the COVID-19–related restrictions: Data from an institutional registry
Authors: Aimilios Lallas, Athanassios Kyrgidis, Sofia-Magdalini Manoli, Chryssoula Papageorgiou, Konstantinos Lallas, Elena Sotiriou, Efstratios Vakirlis, Theodoros Sidiropoulos, Dimitrios Ioannides, Zoe Apalla
Journal: Journal of the American Academy of Dermatology (2021)

To the Editor: During 2020, restrictions applied to limit COVID-19 dissemination radically modified health care services. In Greece, during the lockdown introduced in March, the routine functions of dermatology outpatient clinics were suspended, prioritizing only emergencies, including lesions suspicious for skin cancer, because of rapid growth or clinicians' referrals. This resulted in a reduction in the number of patients examined by approximately 80%. Limited routine diagnostic procedures restarted after 2 months until late October, when a new lockdown was imposed because of a second COVID-19 outbreak. These health care disruptions raised worldwide concerns about their potential impact on early cancer diagnosis and flow-on effects on morbidity and mortality.1Richards M. Anderson M. Carter P. Ebert B.L. Mossialos E. The impact of the COVID-19 pandemic on cancer care.Nat Cancer. 2020; 1: 565-567Crossref PubMed Scopus (355) Google Scholar,2Maringe C. Spicer J. Morris M. et al.The impact of the COVID-19 pandemic on cancer deaths due to delays in diagnosis in England, UK: a national, population-based, modelling study.Lancet Oncol. 2020; 21: 1023-1034Abstract Full Text Full Text PDF PubMed Scopus (1099) Google Scholar A United Kingdom-based modeling study demonstrated an up to 10% increase in mortality due to common neoplasms.2Maringe C. Spicer J. Morris M. et al.The impact of the COVID-19 pandemic on cancer deaths due to delays in diagnosis in England, UK: a national, population-based, modelling study.Lancet Oncol. 2020; 21: 1023-1034Abstract Full Text Full Text PDF PubMed Scopus (1099) Google Scholar,3Mitchell E.P. Declines in cancer screening during COVID-19 pandemic.J Natl Med Assoc. 2020; 112: 563-564Crossref PubMed Scopus (24) Google Scholar We retrieved data from an institutional skin cancer registry in Northern Greece to assess the impact of the pandemic on skin cancer diagnosis. We compared the observed and expected numbers of new melanomas (per stage), basal cell carcinomas, and squamous cell carcinomas in 2020. The expected incidence of each tumor and melanoma stage was calculated as the mean of the previous 4 years (2016-2019), assuming that the incidence would remain stable in 2020.4Lallas A. Apalla Z. Kyrgidis A. et al.Second primary melanomas in a cohort of 977 melanoma patients within the first 5 years of monitoring.J Am Acad Dermatol. 2020; 82: 398-406Abstract Full Text Full Text PDF PubMed Scopus (33) Google Scholar The analytical results are shown in Table I and Fig 1. The total number of new skin cancers was 30.1% lower than the expected number. The reduction was 36.4%, 22.3%, and 44.8% for melanoma, basal cell carcinoma, and squamous cell carcinoma, respectively. Melanoma and basal cell carcinoma patients were significantly younger at the time of diagnosis in 2020 than those in previous years, and a similar trend was found for squamous cell carcinoma patients, reflecting the increased concerns regarding COVID-19 among elderly individuals. Similarly, a higher-than-expected female representation may mirror the increased fear of severe COVID-19 consequences among men.Table IObserved and expected newly diagnosed skin cancers during 2020 in a skin cancer referral center in Northern GreeceVariablesExpectedObservedP value∗Pearson's χ2 test.All skin cancers855598<.001Melanomas165105<.001Breslow thickness (mm) Mean1.8 ± 2.02.2 ± 1.9.1838†Student t test. Median1.51.8Melanoma stage 044 (26.7%)19 (18.1%)<.001 IA23 (13.9%)11 (10.5%) IB29 (17.6%)19 (18.1%) IIA12 (7.3%)9 (8.6%) IIB11 (6.7%)8 (7.6%) IIC6 (3.6%)8 (7.6%) III19 (11.5%)15 (14.3%) IV21 (12.7%)16 (15.2%)Age (years)58.69 ± 15.0551.12 ± 11.36<.001†Student t test.Male:female1.1:11:1Previous melanoma history12 (7.2%)13 (12.4%)Basal cell carcinomas498387<.001Age (years)72.6 ± 19.467.8 ± 14.66<.001†Student t test.Male:female1.6:11.2:1Squamous cell carcinomas192106<.001Age (years)75.2 ± 9.373.4 ± 12.11.267†Student t test.Male:female2.9:12.8:1Bold means statistically significant.∗ Pearson's χ2 test.† Student t test. Open table in a new tab Bold means statistically significant. A substantially lower-than-expected proportion of melanomas was diagnosed at stages 0 and IA and a significantly higher-than-expected percentage at stages IIC, III, and IV. Notably, the number of new melanomas diagnosed in patients with a previous melanoma history was slightly higher than expected, suggesting that high awareness among this group prevented diagnostic delays. Concerns about potential diagnostic delays for cancers, with subsequent effects on morbidity and mortality, due to pandemic-related disruptions were expressed early in the course of the COVID-19 outbreak.2Maringe C. Spicer J. Morris M. et al.The impact of the COVID-19 pandemic on cancer deaths due to delays in diagnosis in England, UK: a national, population-based, modelling study.Lancet Oncol. 2020; 21: 1023-1034Abstract Full Text Full Text PDF PubMed Scopus (1099) Google Scholar Our results confirm this fear by revealing a reduced number of diagnosed skin cancers and a trend toward a more advanced melanoma stage at the time of diagnosis. A previous study in the United States reported significantly fewer and more advanced melanomas during 2 months in 2020 than in the same period in 2019.5Shannon A.B. Sharon C.E. Straker III, R.J. et al.The impact of the COVID-19 pandemic on the presentation status of newly diagnosed melanoma: a single institution experience.J Am Acad Dermatol. 2021; 84: 1096-1098Abstract Full Text Full Text PDF PubMed Scopus (31) Google Scholar Similar observations have been reported for other common cancers.1Richards M. Anderson M. Carter P. Ebert B.L. Mossialos E. The impact of the COVID-19 pandemic on cancer care.Nat Cancer. 2020; 1: 565-567Crossref PubMed Scopus (355) Google Scholar, 2Maringe C. Spicer J. Morris M. et al.The impact of the COVID-19 pandemic on cancer deaths due to delays in diagnosis in England, UK: a national, population-based, modelling study.Lancet Oncol. 2020; 21: 1023-1034Abstract Full Text Full Text PDF PubMed Scopus (1099) Google Scholar, 3Mitchell E.P. Declines in cancer screening during COVID-19 pandemic.J Natl Med Assoc. 2020; 112: 563-564Crossref PubMed Scopus (24) Google Scholar Our results indicate that skin cancer diagnosis is delayed because of COVID-19–related restrictions. Future studies should assess whether this affects melanoma-related morbidity and mortality. Considering the prolonged course of the pandemic, actions toward maintaining open access pathways for skin cancer diagnosis and reclamation of the health care-seeking attitude of the population are mandatory. Teledermatology may facilitate a diagnostic process to decrease the risk of prolonged diagnostic delay for skin cancers. None disclosed.