tbuckley/cabot-search huggingface dataset:
Thinking More About Inhibition of Breast Milk on the Infectivity of SARS-CoV-2—Reply
Authors: Bridget E. Young, Kirsi M. Järvinen, Antti Seppo
Journal: JAMA Pediatrics (2022)

In Reply We wish to thank Zhou at al for their insightful comments on our study.1 The authors make an excellent point that some of the neutralization activity of human breast milk against SARS-CoV-2 may be attributed to other nonimmunoglobulin factors in breast milk.
PLoS Medicine Issue Image | Vol. 3(9) September 2006
Journal: PLoS Medicine (2006)

The cover image takes its theme from the paper by Christopher Murray, Majid Ezzati, and colleagues, which uses a number of factors including race, sex, and place of residence to investigate patterns of mortality across the United States. Using such combinations, the authors defined "eight Americas," between which life expectancy could vary by as much as 20 years. Image Credit: Cover design by Natalie Davis, Public Library of Science, with image taken from Murray et al.
Acquired Resistance to KRAS<sup>G12C</sup> Inhibition in Cancer
Authors: Mark M. Awad, Shengwu Liu, Igor I. Rybkin, Kathryn C. Arbour, Julien Dilly, Viola W. Zhu, Melissa L. Johnson, Rebecca S. Heist, Tejas Patil, Gregory J. Riely, Joseph O. Jacobson, Xiaoping Yang, Nicole S. Persky, David E. Root, Kristen E. Lowder, Hanrong Feng, Shannon S. Zhang, Kevin M. Haigis, Yin P. Hung, Lynette M. Sholl, Brian M. Wolpin, Julie Wiese, Jason Christiansen, Jessica Lee, Alexa B. Schrock, Lee P. Lim, Kavita Garg, Mark Li, Lars D. Engstrom, Laura Waters, J. David Lawson, Peter Olson, Piro Lito, Sai-Hong I. Ou, James G. Christensen, Pasi A. Jänne, Andrew J. Aguirre
Journal: New England Journal of Medicine (2021)

Clinical trials of the KRAS inhibitors adagrasib and sotorasib have shown promising activity in cancers harboring KRAS glycine-to-cysteine amino acid substitutions at codon 12 (KRAS
Evaluation of an iron preparation for intramuscular use. Iron sorbitex (jectofer)
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Role of molybdenum in material immunomodulation and periodontal wound healing: Targeting immunometabolism and mitochondrial function for macrophage modulation
Authors: Xiao-Tao He, Xuan Li, Meng Zhang, Bei-Min Tian, Li-Juan Sun, Chun-Sheng Bi, Dao-Kun Deng, Huan Zhou, Hong-Lei Qu, Chengtie Wu, Fa-Ming Chen
Journal: Biomaterials (2022)
<i>HEATR3</i> variants impair nuclear import of uL18 (RPL5) and drive Diamond-Blackfan anemia
Authors: Marie-Françoise O’Donohue, Lydie Da Costa, Marco Lezzerini, Sule Unal, Clément Joret, Marije Bartels, Eva Brilstra, Marijn Scheijde-Vermeulen, Ludivine Wacheul, Kim De Keersmaecker, Stijn Vereecke, Veerle Labarque, Manon Saby, Sophie D. Lefevre, Jessica Platon, Nathalie Montel-Lehry, Nathalie Laugero, Eric Lacazette, Koen van Gassen, Riekelt H. Houtkooper, Pelin Ozlem Simsek-Kiper, Thierry Leblanc, Nese Yarali, Arda Cetinkaya, Nurten A. Akarsu, Pierre-Emmanuel Gleizes, Denis L. J. Lafontaine, Alyson W. MacInnes
Journal: Blood (2022)

The congenital bone marrow failure syndrome Diamond-Blackfan anemia (DBA) is typically associated with variants in ribosomal protein (RP) genes impairing erythroid cell development. Here we report multiple individuals with biallelic HEATR3 variants exhibiting bone marrow failure, short stature, facial and acromelic dysmorphic features, and intellectual disability. These variants destabilize a protein whose yeast homolog is known to synchronize the nuclear import of RPs uL5 (RPL11) and uL18 (RPL5), which are both critical for producing ribosomal subunits and for stabilizing the p53 tumor suppressor when ribosome biogenesis is compromised. Expression of HEATR3 variants or repression of HEATR3 expression in primary cells, cell lines of various origins, and yeast models impairs growth, differentiation, pre-ribosomal RNA processing, and ribosomal subunit formation reminiscent of DBA models of large subunit RP gene variants. Consistent with a role of HEATR3 in RP import, HEATR3-depleted cells or patient-derived fibroblasts display reduced nuclear accumulation of uL18. Hematopoietic progenitor cells expressing HEATR3 variants or small-hairpin RNAs knocking down HEATR3 synthesis reveal abnormal acceleration of erythrocyte maturation coupled to severe proliferation defects that are independent of p53 activation. Our study uncovers a new pathophysiological mechanism leading to DBA driven by biallelic HEATR3 variants and the destabilization of a nuclear import protein important for ribosome biogenesis.
Purse-string suture combined with titanium clips using a single-channel gastroscope for the closure of postintubation tracheoesophageal fistula
Authors: Shu Huang, Sumin Zhu, Siming Guo, Xuan Zhao
Journal: Endoscopy (2022)

A 72-year-old woman was treated with endotracheal intubation and mechanical ventilation for shock caused by herbicide poisoning. After extubation she presented with cough. Tracheoscopy and gastroscopy both showed a perforation measuring about 1 cm ([Fig. 1 a, b]). The tracheoesophageal fistula (TEF) was treated with a purse-string suture via a gastroscope (GIF-Q260J; Olympus, Tokyo, Japan) ([Video 1]). In brief, an endoloop (Leo Medical, Changzhou, China) was inserted by forceps and anchored onto the full thickness of the edge of the fistula, including both the esophageal wall and the tracheal wall, with a titanium clip (Micro-Tech, Nanjing, China) ([Fig. 1 c]). After adjustment of the angle, three additional repositionable clips were used to secure the endoloop on different sides of fistula. The removable hook was then inserted and connected with the ring on the tail of the endoloop, which was tightened to pull the edges of the fistula together. The hook was then removed and the TEF was closed ([Fig. 1 d]). To further strengthen the closure of the fistula, an endoclip was added to clamp the still visible small hole ([Fig. 1 e]). The patient was put on nasal feeding after operation and her cough took a turn for the better. One month later, gastroscopy showed that the endoclips and endoloop had fallen off and the fistula was reduced to 0.3 cm, which was clamped with three clips ([Fig. 2]). Another 3 months later, gastroscopy and upper gastrointestinal radiography revealed the fistula to have closed ([Fig. 3]).
Amyloid deposition in the eyelids
Authors: J. J. Zuravleff
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Interpreters of Nature—Essays.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Skeletal muscle alterations and exercise intolerance in heart failure with preserved ejection fraction patients: ultrasonography assessment of diaphragm and quadriceps
Authors: Maria Andriopoulou, Niki Dimaki, Manolis S. Kallistratos, Eftihia Chamodraka, Edison Jahaj, Alice G. Vassiliou, Georgios Giokas, Anastasia Kotanidou, Athanasios J. Manolis, Massimo F. Piepoli, Gerasimos Filippatos
Journal: European Journal of Heart Failure (2022)
Book Review Acute Injuries of the Head: Their diagnosis, treatment, complications and sequels. By G. F. Rowbotham, B.Sc. (Manch.), F.R.C.S. (Eng.). With a foreword by Norman M. Dott, M.B., Ch.B. (Edin.), F.R.C.S. (Edin.). 8°, cloth, 424 pp., with 201 illustrations. Baltimore: The Williams and Wilkins Company, 1945. $8.50.
Journal: New England Journal of Medicine (1946)
Sweet's Syndrome
Authors: Jesse I. Spector
Journal: JAMA (1980)

IN 1964 Sweet described a distinctive dermatologic disease with systemic manifestations that he called acute febrile neutrophilic dermatosis. The skin condition consists of painful, raised plaques, nodules, and pustules that histologically show a perivascular neutrophilic infiltrate in the dermis. The eruption occurs acutely or episodically and is almost always accompanied by fever and neutrophilic leukocytosis. Antibiotics are ineffective, but corticosteroids result in prompt resolution without scarring. Eight previously reported<sup>1-5</sup>cases described patients with Sweet's syndrome who experienced acute leukemia during the course of their illness. We report two other cases of Sweet's syndrome in which leukemia developed and emphasize that this dermatosis appears to be associated with hematologic malignant conditions. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 45-year-old woman was hospitalized in March 1977 after having had development of painful skin eruptions over the face, neck, chest, and extremities (and similar painful lesions in the mouth) during a three-week period,
HELPING PHYSICIANS TO KEEP ABREAST OF THE LAW
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aortic rupture into the esophagus during angiography
Authors: H. T. Dale
Journal: JAMA (1978)

A 67-year-old woman was examined and found to have symptoms and chest roentgenogram suggesting acute aortic dissection. During emergency angiography, massive upper gastrointestinal bleeding developed, and the woman died. The angiogram showed a raised intimal flap of acute dissecting aneurysm. Postmortem examination showed extensive cystic medial necrosis, aortic dilation, and an unusual combination of anatomic abnormalities, which explained the previously unreported false-positive intimal flap. The site of aortic rupture was not localized, but a large tear was found in the esophagus. (<i>JAMA</i>239:1880-1881, 1978)
ROSEOLA INFANTUM
Authors: JOHN ZAHORSKY
Journal: JAMA (1913)

The name "roseola infantilis" had an important place in the medical terminology of writers on skin diseases fifty years ago. Willan distinguished several varieties, and subsequent writers followed his classification with some variations. The older works on pediatrics had descriptions of the disease, but it is obvious from these descriptions that many different eruptions were confused under this heading as Hardaway<sup>1</sup>pointed out. On the advice of the dermatologists the name was dropped and recent text-books on pediatrics do not mention this affection. For many years I have been interested in a symptom-complex, a febrile erythema, which occurs almost exclusively in infants and which deserves a place outside of the erythema group of skin diseases. To this the older writers gave the name "roseola infantilis," but did not differentiate this disease from rubella and toxic erythemata. In 1909 I discussed this subject before the St. Louis Pediatric society and
Queries and Minor Notes
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology
Authors: David Tamborero, Rodrigo Dienstmann, Maan Haj Rachid, Jorrit Boekel, Adria Lopez-Fernandez, Markus Jonsson, Ali Razzak, Irene Braña, Luigi De Petris, Jeffrey Yachnin, Richard D. Baird, Yohann Loriot, Christophe Massard, Patricia Martin-Romano, Frans Opdam, Richard F. Schlenk, Claudio Vernieri, Michele Masucci, Xenia Villalobos, Elena Chavarria, Shubha Anand, Danny Baars, Svetlana Bajalica-Lagercrantz, Richard Baird, Mariska Bierkens, Lennart Blomqvist, Costanza Bono, Luigi De Petris, Gary J. Doherty, Arnauld Forest, Valentina Fornerone, Paola Gabaldi, Felix Haglund, Johan Hartman, Peter Horak, Tanja Jutzi, Mary Kasanicki, Simon Kreutzfeldt, Lucian Le Cornet, Rolf Lewensohn, Johan Lindberg, Carlos Lopez, Andreas Lundqvist, Jose-Ezequiel Martin, Gerrit Meijer, Susana Muñoz, Maud Ngo Camus, Claudio Nicotra, Paolo Nuciforo, Petra Oberrauch, Päivi Östling, Laura Pelz, Alejandro Piris-Gimenez, Elena Provenzano, Etienne Rouleau, John Rowell, Omar Saavedra, Giovanni Scoazec, Kenneth Seamon, Marc Tischkowitz, Lizet van der Kolk, Ruud van der Noll, Maria Vieito, Daniel Vis, Ana Vivancos, Christina von Gertten, Anders Wennborg, Lodewyk Wessels, Valtteri Wirta, Judith Balmaña, Giovanni Apolone, Carlos Caldas, Jonas Bergh, Ingemar Ernberg, Stefan Fröhling, Elena Garralda, Claes Karlsson, Josep Tabernero, Emile Voest, Jordi Rodon, Janne Lehtiö
Journal: Nature Cancer (2022)

There is a growing need for systems that efficiently support the work of medical teams at the precision-oncology point of care. Here, we present the implementation of the Molecular Tumor Board Portal (MTBP), an academic clinical decision support system developed under the umbrella of Cancer Core Europe that creates a unified legal, scientific and technological platform to share and harness next-generation sequencing data. Automating the interpretation and reporting of sequencing results decrease the need for time-consuming manual procedures that are prone to errors. The adoption of an expert-agreed process to systematically link tumor molecular profiles with clinical actions promotes consistent decision-making and structured data capture across the connected centers. The use of information-rich patient reports with interactive content facilitates collaborative discussion of complex cases during virtual molecular tumor board meetings. Overall, streamlined digital systems like the MTBP are crucial to better address the challenges brought by precision oncology and accelerate the use of emerging biomarkers.
Early increase in single-kidney glomerular filtration rate after living kidney donation predicts long-term kidney function
Authors: Jessica van der Weijden, Shekar V.K. Mahesh, Marco van Londen, Stephan J.L. Bakker, Jan-Stephan Sanders, Gerjan Navis, Robert A. Pol, Joke I. Roodnat, Marcia M.L. Kho, Derya Yakar, Thomas C. Kwee, Ilja M. Nolte, Stefan P. Berger, Martin H. De Borst
Journal: Kidney International (2022)

Single-kidney glomerular filtration rate (GFR) increases after living kidney donation due to compensatory hyperfiltration and structural changes. The implications of inter-individual variability in this increase in single-kidney GFR are unknown. Here, we aimed to identify determinants of the increase in single-kidney GFR at three-month postdonation, and to investigate its relationship with long-term kidney function. In a cohort study in 1024 donors, we found considerable inter-individual variability of the early increase in remaining single-kidney estimated GFR (eGFR) (median [25th-75th percentile]) 12 [8-18] mL/min/1.73m2. Predonation eGFR, age, and cortical kidney volume measured by CT were the main determinants of the early postdonation increase in single-kidney eGFR. Individuals with a stronger early increase in single-kidney eGFR had a significantly higher five-year postdonation eGFR, independent of predonation eGFR and age. Addition of the postdonation increase in single-kidney eGFR to a model including predonation eGFR and age significantly improved prediction of a five-year postdonation eGFR under 50 mL/min/1.73m2. Results at ten-year follow-up were comparable, while accounting for left-right differences in kidney volume did not materially change the results. Internal validation using 125I-iothalamate-based measured GFR in 529 donors and external validation using eGFR data in 647 donors yielded highly similar results. Thus, individuals with a more pronounced increase in single-kidney GFR had better long-term kidney function, independent of predonation GFR and age. Hence, the early postdonation increase in single-kidney GFR, considered indicative for kidney reserve capacity, may have additional value to eGFR and age to personalize follow-up intensity after living kidney donation.
THE DOCTOR IN THE SCHOOLROOM.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models
Authors: Han-Yi Huang, Hsin-Yu Liao, Xiaorui Chen, Szu-Wen Wang, Cheng-Wei Cheng, Md. Shahed-Al-Mahmud, Yo-Min Liu, Arpita Mohapatra, Ting-Hua Chen, Jennifer M. Lo, Yi-Min Wu, Hsiu-Hua Ma, Yi-Hsuan Chang, Ho-Yang Tsai, Yu-Chi Chou, Yi-Ping Hsueh, Ching-Yen Tsai, Pau-Yi Huang, Sui-Yuan Chang, Tai-Ling Chao, Han-Chieh Kao, Ya-Min Tsai, Yen-Hui Chen, Chung-Yi Wu, Jia-Tsrong Jan, Ting-Jen Rachel Cheng, Kuo-I Lin, Che Ma, Chi-Huey Wong
Journal: Science Translational Medicine (2022)

A major challenge to end the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to develop a broadly protective vaccine that elicits long-term immunity. As the key immunogen, the viral surface spike (S) protein is frequently mutated, and conserved epitopes are shielded by glycans. Here, we revealed that S protein glycosylation has site-differential effects on viral infectivity. We found that S protein generated by lung epithelial cells has glycoforms associated with increased infectivity. Compared to the fully glycosylated S protein, immunization of S protein with N-glycans trimmed to the mono-GlcNAc-decorated state (SMG) elicited stronger immune responses and better protection for human angiotensin-converting enzyme 2 (hACE2) transgenic mice against variants of concern (VOCs). In addition, a broadly neutralizing monoclonal antibody was identified from SMG-immunized mice that could neutralize wild-type SARS-CoV-2 and VOCs with subpicomolar potency. Together, these results demonstrate that removal of glycan shields to better expose the conserved sequences has the potential to be an effective and simple approach for developing a broadly protective SARS-CoV-2 vaccine.