tbuckley/cabot-search huggingface dataset:
Response to: ‘Antirheumatic drugs, B cell depletion and critical COVID-19: correspondence on ‘Clinical course of coronavirus disease 2019 (COVID-19) in a series of 17 patients with systemic lupus erythematosus under long-term treatment with hydroxychloroquine by Mathian<i>et al</i>’ by Notz<i>et al</i>
Authors: Alexis Mathian, Zahir Amoura
Journal: Annals of the Rheumatic Diseases (2020)

Treatment of patients with human epidermal growth factor receptor 2 (HER2)–expressing tumors using the monoclonal antibody trastuzumab increases survival. The Affibody-based peptide nucleic acid (PNA)–mediated pretargeted radionuclide therapy has demonstrated efficacy against HER2-expressing xenografts in mice. Structural studies suggest that Affibody molecules and trastuzumab bind to different epitopes on HER2. The aim of this study was to test the hypothesis that a combination of PNA-mediated pretargeted radionuclide therapy and trastuzumab treatment of HER2-expressing xenografts can extend survival compared with monotherapies. <b>Methods:</b> Mutual interference of the primary pretargeting probe Z<sub>HER2:342</sub>-SR-<i>HP1</i> and trastuzumab in binding to HER2-expressing cell lines was investigated in&nbsp;vitro. Experimental therapy evaluated the survival of mice bearing HER2-expressing SKOV-3 xenografts after treatment with vehicle, trastuzumab only, pretargeting using Affibody-PNA chimera Z<sub>HER2:342</sub>-SR-<i>HP1</i> and complementary probe <sup>177</sup>Lu-<i>HP2</i>, and combination of trastuzumab and pretargeting. The ethical permit limited the study to 90 d. The animals’ weights were monitored during the study. After study termination, samples of liver and kidneys were evaluated by a veterinary pathologist for toxicity signs. <b>Results:</b> The presence of a large molar excess of trastuzumab had no influence on the affinity of Z<sub>HER2:342</sub>-SR-<i>HP1</i> binding to HER2-expressing cells in&nbsp;vitro. The affinity of trastuzumab was not affected by a large excess of Z<sub>HER2:342</sub>-SR-<i>HP1</i>. The median survival of mice treated with trastuzumab (75.5 d) was significantly longer than the survival of mice treated with a vehicle (59.5 d). Median survival of mice treated with pretargeting was not reached by day 90. Six mice of 10 in this group survived, and 2 had complete remission. All mice in the combination treatment group survived, and tumors in 7 mice had disappeared at study termination. There was no significant difference between animal weights in the different treatment groups. No significant pathologic alterations were detected in livers and kidneys of treated animals. <b>Conclusion:</b> Treatment of mice bearing HER2-expressing xenografts with the combination of trastuzumab and Affibody-mediated PNA-based radionuclide pretargeting significantly increased survival compared with monotherapies. Cotreatment was not toxic for normal tissues.
Abstract S07-03: Scientia potentia est: How the Italian world of oncology changes in the COVID19 pandemic
Authors: Zelmira Ballatore, Lucia Bastianelli, Filippo Merloni, Nicoletta Ranallo, Luca Cantini, Lorenzo Mariotti, Claudia Catani, Michela Burattini, Alessandra Lucarelli, Rossana Berardi
Journal: Clinical Cancer Research (2020)

Abstract Background: After COVID-19 was declared a pandemic by the World Health Organization, a response from the Italian Health System to react to an unprecedented condition became necessary and sudden. COVID- 19 pandemic required oncologists to redefine clinical organization and management of cancer patients. The aim of our study was to take a picture of the situation of Italian oncologies and to evaluate the difficulties in patients’ management. Methods: Between 18th March and 9th April 2020 we conducted an online survey (Google Forms). It consisted of 45 questions ranging from individual perception of pandemic management by oncologic centers to physicians’ and nurses’ psychological distress and patient care. The survey was anonymous and broadcast to oncology health workers by mailing contacts, word of mouth, and social networks. Results: A total of 383 oncology health workers participated in the survey. The majority was female (72%) and from central Italy (46%). Impressively, a total of 357 (93%) participants declared the Oncologic Department reorganized routine clinical activity, but only 41% were adequately trained about the required procedures. 20% of the survey attendees thought they had not received adequate and timely protective devices with respect to clinical needs, and according to 58% the supply of these devices was only partial. 34% of professionals declared that they did not have or know a defined common guideline to reschedule patients’ treatments. More than 80% of interviewees declared feeling worried about being at greater risk of contagion than the general population, and 92% feared to transmit virus to family members. Deferring treatments has caused fear/anxiety in 228 of the interviewed (60%). Symptoms of stressful situations emerged with a deterioration in sleep quality in 62% of professionals, worsening of mood (69%), and lower concentration ability (49%). Conclusions: Our survey demonstrated the flexibility of oncologic teams. However, the emergency response quality has been heterogeneous, and several drawbacks emerged from this first analysis. Information, protection, testing, and training of health care professionals are keywords that should be kept in mind to encourage recovery after this tragedy and to be ready to face a similar emergency in the near future. Citation Format: Zelmira Ballatore, Lucia Bastianelli, Filippo Merloni, Nicoletta Ranallo, Luca Cantini, Lorenzo Mariotti, Claudia Catani, Michela Burattini, Alessandra Lucarelli, Rossana Berardi. Scientia potentia est: How the Italian world of oncology changes in the COVID19 pandemic [abstract]. In: Proceedings of the AACR Virtual Meeting: COVID-19 and Cancer; 2020 Jul 20-22. Philadelphia (PA): AACR; Clin Cancer Res 2020;26(18_Suppl):Abstract nr S07-03.
Multiple Pathways for Pathological Calcification in the Human Body
Authors: Netta Vidavsky, Jennie A. M. R. Kunitake, Lara A. Estroff
Journal: Advanced Healthcare Materials (2020)

Biomineralization of skeletal components (e.g., bone and teeth) is generally accepted to occur under strict cellular regulation, leading to mineral-organic composites with hierarchical structures and properties optimized for their designated function. Such cellular regulation includes promoting mineralization at desired sites as well as inhibiting mineralization in soft tissues and other undesirable locations. In contrast, pathological mineralization, with potentially harmful health effects, can occur as a result of tissue or metabolic abnormalities, disease, or implantation of certain biomaterials. This progress report defines mineralization pathway components and identifies the commonalities (and differences) between physiological (e.g., bone remodeling) and pathological calcification formation pathways, based, in part, upon the extent of cellular control within the system. These concepts are discussed in representative examples of calcium phosphate-based pathological mineralization in cancer (breast, thyroid, ovarian, and meningioma) and in cardiovascular disease. In-depth mechanistic understanding of pathological mineralization requires utilizing state-of-the-art materials science imaging and characterization techniques, focusing not only on the final deposits, but also on the earlier stages of crystal nucleation, growth, and aggregation. Such mechanistic understanding will further enable the use of pathological calcifications in diagnosis and prognosis, as well as possibly provide insights into preventative treatments for detrimental mineralization in disease.
16510 A randomized, controlled, evaluator-blinded, multicenter study to evaluate the effectiveness and safety of HArk versus a control in the augmentation of soft tissue fullness of the lip
Authors: Robert Weiss, Kenneth Beer, Kimberly Butterwick, Sue Ellen Cox, Michael S. Kaminer, Joely Kaufman, Melanie Palm
Journal: Journal of the American Academy of Dermatology (2020)
The chronic use of multiple photosensitizing drugs is associated with Breslow thickness in female melanoma patients: A bicentric retrospective study
Authors: Emi Dika, Simona Mastroeni, Martina Lambertini, Federica Scarfì, Annalisa Patrizi, Giulia Veronesi, Elisabetta Magnaterra, Alessandro Borghi, Monica Corazza, Igor Diemberger, Elisabetta Poluzzi, Cristina Fortes
Journal: Journal of the American Academy of Dermatology (2020)
Time to add screening for financial hardship as a quality measure?
Authors: Cathy J. Bradley, K. Robin Yabroff, S. Yousuf Zafar, Ya‐Chen Tina Shih
Journal: CA A Cancer Journal for Clinicians (2020)

Cancer treatment is associated with financial hardship for many patients and families. Screening for financial hardship and referrals to appropriate resources for mitigation are not currently part of most clinical practices. In fact, discussions regarding the cost of treatment occur infrequently in clinical practice. As the cost of cancer treatment continues to rise, the need to mitigate adverse consequences of financial hardship grows more urgent. The introduction of quality measurement and reporting has been successful in establishing standards of care, reducing disparities in receipt of care, and improving other aspects of cancer care outcomes within and across providers. The authors propose the development and adoption of financial hardship screening and management as an additional quality metric for oncology practices. They suggest relevant stakeholders, conveners, and approaches for developing, testing, and implementing a screening and management tool and advocate for endorsement by organizations such as the National Quality Forum and professional societies for oncology care clinicians. The confluence of increasingly high-cost care and widening disparities in ability to pay because of underinsurance and lack of health insurance coverage makes a strong argument to take steps to mitigate the financial consequences of cancer.
Annals Graphic Medicine - Dr. Mom: Holiday Cards for Health Care Workers
Authors: Grace E. Farris
Journal: Annals of Internal Medicine (2020)

Web Exclusives1 December 2020Annals Graphic Medicine - Dr. Mom: Holiday Cards for Health Care WorkersFREEGrace E. Farris, MDGrace E. Farris, MDUniversity of Texas, Austin, Texas (G.E.F.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/G20-0110 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Download figure Download PowerPoint Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: University of Texas, Austin, Texas (G.E.F.)Disclosures: The author has disclosed no conflicts of interest. The form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=G18-0042.Author/Illustrator Information: Grace E. Farris, MD, is an assistant professor of medicine at Dell Medical School at the University of Texas in Austin, Texas. You can view her work at her website: www.farrisgrace.com.About Dr. Mom: In Dr. Mom, physician and cartoonist Grace Farris examines work–life balance while mothering and doctoring. Dr. Mom appears monthly in Annals Graphic Medicine at Annals.org. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 2020Volume 173, Issue 11Page: W150-W151 ePublished: 1 December 2020 Issue Published: 1 December 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Cardiovascular Risk Assessment for Noncardiac Surgery—Reply
Authors: Nathaniel R. Smilowitz, Jeffrey S. Berger
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Holter Electrocardiogram Parameters in Risk Stratification of Arrhythmic Events in Idiopathic Dilated Cardiomyopathy: More Studies Are Needed⁎⁎Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Authors: Wojciech Zareba
Journal: Journal of the American College of Cardiology (2007)
Gut Microbiota in Intestinal and Liver Disease
Authors: Rheinallt M. Jones, Andrew S. Neish
Journal: Annual Review of Pathology Mechanisms of Disease (2020)

It is known that the gut microbiota, the numerically vast and taxonomically diverse microbial communities that thrive in a symbiotic fashion within our alimentary tract, can affect the normal physiology of the gastrointestinal tract and liver. Further, disturbances of the microbiota community structure from both endogenous and exogenous influences as well as the failure of host responsive mechanisms have been implicated in a variety of disease processes. Mechanistically, alterations in intestinal permeability and dysbiosis of the microbiota can result in inflammation, immune activation, and exposure to xenobiotic influences. Additionally, the gut and liver are continually exposed to small molecule products of the microbiota with proinflammatory, gene regulatory, and oxidative properties. Long-term coevolution has led to tolerance and incorporation of these influences into normal physiology and homeostasis; conversely, changes in this equilibrium from either the host or the microbial side can result in a wide variety of immune, inflammatory, metabolic, and neoplastic intestinal and hepatic disorders.
Clinical trials in critical care: can a Bayesian approach enhance clinical and scientific decision making?
Authors: Christopher J Yarnell, Darryl Abrams, Matthew R Baldwin, Daniel Brodie, Eddy Fan, Niall D Ferguson, May Hua, Purnema Madahar, Danny F McAuley, Laveena Munshi, Gavin D Perkins, Gordon Rubenfeld, Arthur S Slutsky, Hannah Wunsch, Robert A Fowler, George Tomlinson, Jeremy R Beitler, Ewan C Goligher
Journal: The Lancet Respiratory Medicine (2020)
16877 Topical rotational treatment induces dermal collagen changes evidenced by immunohistochemistry and confocal Raman spectroscopy
Authors: Lisa DiNatale, Jolanta Idkowiak-Baldys, Avon Products, Rubinder Basson, Weiping Li, John Lyga, Anthony Gonzalez, Ardeshir Bayat
Journal: Journal of the American Academy of Dermatology (2020)
Programmable N6-methyladenosine modification of CDCP1 mRNA by RCas9-methyltransferase like 3 conjugates promotes bladder cancer development
Authors: Xiaoling Ying, Xu Jiang, Haiqing Zhang, Bixia Liu, Yapeng Huang, Xiaowei Zhu, Defeng Qi, Gang Yuan, Junhang Luo, Weidong Ji
Journal: Molecular Cancer (2020)

Abstract Accumulating evidence has revealed significant roles for N6-methyladenosine (m 6 A) modification in the development of various cancers. We previously demonstrated an oncogenic role of m 6 A-modified CUB domain containing protein 1 (CDCP1) in bladder cancer (BC) progression. However, the biological functions and underlying molecular mechanisms of engineered programmable m 6 A modification of CDCP1 mRNA in BC remain obscure. Here, we established a targeted m 6 A RNA methylation system by fusing the catalytic domain of methyltransferase like 3 (METTL3CD) to RCas9 as the RNA-targeting module. The constructed RCas9- METTL3 retained methylation activity and mediated efficient site-specific m 6 A installation in the presence of a cognate single guide RNA and short protospacer adjacent motif-containing ssDNA molecule . Subsequently, targeting m 6 A installation onto the 3′ untranslated region of CDCP1 promoted CDCP1 mRNA translation and facilitated BC development in vitro and in vivo. Our findings demonstrate that the RCas9-METTL3 system mediates efficient sitespecific m 6 A installation on CDCP1 mRNA and promotes BC development. Thus, the RCas9-METTL3 system provides a new tool for studying m 6 A function and a potential strategy for BC epitranscriptome-modulating therapies.
134P Effect of preoperative tumour under-staging on the long-term survival of patients undergoing radical gastrectomy for gastric cancer
Authors: M. Lin, S-J. Que, K. Weng, Q-Y. Chen, C-H. Zheng, P. Li, J-W. Xie, J-B. Wang, J-X. Lin, J. Lu, L-L. Cao, R-H. Tu, Z-N. Huang, J-L. Lin, H-L. Zheng, C. Huang
Journal: Annals of Oncology (2020)
Successful double-lung transplantation from a donor previously infected with SARS-CoV-2
Authors: Laurens J Ceulemans, Jan Van Slambrouck, Paul De Leyn, Herbert Decaluwé, Hans Van Veer, Lieven Depypere, Vincent Ceuterick, Stijn E Verleden, Arno Vanstapel, Stefanie Desmet, Piet Maes, Marc Van Ranst, Piet Lormans, Geert Meyfroidt, Arne P Neyrinck, Bart M Vanaudenaerde, Eric Van Wijngaerden, Saskia Bos, Laurent Godinas, Peter Carmeliet, Geert M Verleden, Dirk E Van Raemdonck, Robin Vos
Journal: The Lancet Respiratory Medicine (2020)
CT Defined Atherosclerotic Plaque Type and Severity: Using the Results of the Diagnostic Microscope to Sharpen the Clarity of Peering Through the Prognostic Telescope⁎⁎Editorials published in JACC: Cardiovascular Imaging reflect the views of the authors and do not necessarily represent the views of JACC: Cardiovascular Imaging or the American College of Cardiology.
Authors: John A. Rumberger
Journal: JACC. Cardiovascular imaging (2012)
184P Development and external validation of a nomogram to predict recurrence-free survival after R0 resection for stage II/III gastric adenocarcinoma: An international multicenter study
Authors: B-B. Xu, Z. Xue, D. Wu, J. Lu, M.J. Truty, J-W. Xie, J-B. Wang, J-X. Lin, Q-Y. Chen, L-L. Cao, M. Lin, R-H. Tu, Z-N. Huang, J-L. Lin, H-L. Zheng, P. Li, C-H. Zheng, C. Huang
Journal: Annals of Oncology (2020)
SARS-CoV-2 and COVID-19 “covidiosyncrasies” and their impact on endoscopists and endoscopy
Authors: Klaus Mönkemüller
Journal: Endoscopy (2020)

Referred to by: Impact of the COVID-19 pandemic on gastrointestinal endoscopy activity in FranceEndoscopy 2020; 52(12): 1111-1115DOI: 10.1055/a-1201-9618
Impact of Chronic Total Occlusion Revascularization on Left Ventricular Function Assessed by Cardiac Magnetic Resonance
Authors: Michael Megaly, Emmanouil S. Brilakis, Mahmoud Abdelsalam, Ashish Pershad, Marwan Saad, Santiago Garcia, M. Nicholas Burke, Erik B. Schelbert, Chiara Bucciarelli-Ducci, João L. Cavalcante
Journal: JACC. Cardiovascular imaging (2020)
A rare cause of multiple airways narrowing in a 15-year-old girl
Authors: Sergio Ghirardo, Federica Porcaro, Maria Beatrice Chiarini Testa, Maria Giovanna Paglietti, Nicola Ullmann, May El Hachem, Fabrizio De Benedetti, Renato Cutrera
Journal: Thorax (2020)

Sergio Ghirardo (SG): a 15-year-old girl was first admitted to our unit, with significant dyspnoea and fatigue at rest. Her clinical history was uneventful until she was 14 years old when she was hospitalised twice for respiratory symptoms, interpreted as post viral wheezing. Treatment with intravenous corticosteroids, salbutamol and azithromycin was of little clinical benefit. In the last 6 months, she complained of progressive exercise-induced dyspnoea, and her lung function showed a moderate-to-severe obstructive pattern (forced expiratory volume in one second, FEV1/forced vital capacity, FVC 56.6%), with no response to salbutamol. Her symptoms did not improve with inhaled corticosteroids, long-acting β2 agonists and montelukast treatment. Clinically, she reported moderate swelling of the nasal dorsum as a consequence of a blow with a ball received 5 months before admission. She had a bilateral transmissive mild hypoacusis and a significative weight loss of 18 kg in only 8 months.

On initial physical examination she appeared pale and tired with a mild redness of the ear helix sparing the lobe and a mild swelling of the nasal dorsum. She was tachypnoeic (20 breaths/min), with normal levels of oxygen saturation. Mild supraclavicular retractions were present during inspiration. On chest auscultation stridor and mild bilateral wheezing were detected. Heart rate was 109 beats/min. The remaining physical examination was normal.

Renato Cutrera (RC): we have a previously healthy female adolescent with a personal history of only partially remitting obstructive dyspnoea suggesting a chronic respiratory infection (like tuberculosis or pulmonary mycosis). However, the fatigue associated with significant weight loss should raise the suspicion of pulmonary hypertension. I suggest performing routine blood tests, chest X-ray, full blood count and cardiological evaluation. At the same time, I would administer oral corticosteroids and antibiotic coverage.

Federica Porcaro (FP): blood tests showed a mild rise of C reactive protein (CRP) 7.2 mg/L (normal range 0–5 mg/L); whereas …
Proteomic and Mechanistic Analysis of Spironolactone in Patients at Risk for HF
Authors: João Pedro Ferreira, Job Verdonschot, Ping Wang, Anne Pizard, Timothy Collier, Fozia Z. Ahmed, Hans-Peter Brunner-La-Rocca, Andrew L. Clark, Franco Cosmi, Joe Cuthbert, Javier Díez, Frank Edelmann, Nicolas Girerd, Arantxa González, Stéphanie Grojean, Mark Hazebroek, Javed Khan, Roberto Latini, Mamas A. Mamas, Beatrice Mariottoni, Blerim Mujaj, Pierpaolo Pellicori, Johannes Petutschnigg, Burkert Pieske, Patrick Rossignol, Philippe Rouet, Jan A. Staessen, John G.F. Cleland, Stephane Heymans, Faiez Zannad
Journal: JACC Heart Failure (2021)
Severe Ocular Graft-Versus-Host Disease Successfully Treated with Amniotic Membrane Transplantation - Case Series
Authors: Zinaida Peric, Ivan Skegro, Nadira Durakovic, Lana Desnica, Ranka Serventi-Seiwerth, Drazen Pulanic, Igor Petricek, Steven Z. Pavletic, Radovan Vrhovac
Journal: Blood (2017)
Retention of men who have sex with men in a pre-exposure prophylaxis programme: survival analysis from a crossover study
Authors: Tsz Ho Kwan, Grace Chung Yan Lui, Krystal Chi Kei Lee, Teddy Tai Ning Lam, Ngai Sze Wong, Denise Pui Chung Chan, Shui Shan Lee
Journal: The Lancet (2020)
100P Individualized treatment of advanced digestive system tumour guided by PDTX mouse model: A multicenter trial
Authors: None Y. Cheng, S. Qin, J. Li, G-H. Dai, B-Y. Shen, J-E. Ying, Y. Ba, X-B. Wang, Y. Xu, L. Zhou, K-F. Ding, Y-R. Qin, S-J. Yang, Y-P. Zhu
Journal: Annals of Oncology (2020)
Neo-LVOT and Transcatheter Mitral Valve Replacement
Authors: Anna Reid, Sagit Ben Zekry, Mansi Turaga, Stephanie Tarazi, Jeroen J Bax, Dee Dee Wang, Nicolo Piazza, Vinayak N Bapat, Abdul Rahman Ihdayhid, João L Cavalcante, Philipp Blanke, Jonathon Leipsic
Journal: JACC. Cardiovascular imaging (2020)