tbuckley/cabot-search huggingface dataset:
FDA considers a first: approval of drug for inhibiting preterm labor
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Allied health programs in the Junior Colleges
Authors: K. G. Skaggs
Journal: JAMA (1968)

If we accept the premise that the nation faces an acute shortage of personnel in the service and supportive fields of health and medical care, then careful attention should be given to making the most effective use of the nation's two-year colleges to educate many who will go into the health and medical services. The capacity for absorbing larger and larger enrollments is apparently one of the most striking features of the two-year college. Related to this apparently infinite capacity is a responsiveness to student needs giving emphasis to a heterogeneous student body; a comprehensive program designed to meet varying needs and all ages of students; a uniquely qualified staff that differs in its preparation and interest from the traditional academic staffs; and a large number of institutions which apparently have widely differing goals, organizational patterns, and procedural methods. Another characteristic of junior colleges is an absence of preconceived notions
Gastric Cancer and Lymphoma
Authors: I Vomgbiova1, S Hurlimann2, A Zimmermann3, L Varga2, R Uibol, B Rudolph, E Bayerdbrffer, B Neubauer, N Warland, Atr Lehn, C Thiede, B Feinauer, C Manegold, H Axon, P Chalmers, R Jatzwauk, M Zeyen, A Stolte
Journal: Gut (1995)

Epidemiological studies have identified an association between HP and gastric carcinoma.Epithelial cell proliferation is an indicator of risk for adenocarcinoma.We aimed to assess the effect of HP on gastric epithelial cell proliferation and on homeostasis of specific cells.In addition we were interested in the expression of the apoptosis proctector oncogenic protein, bcl-2, which was found to be enhanced in a majority of follicular Iymphomas of the gastrointestinal tract and in a few MALT-lymphomas, whereas the latter is associated with HP infection.Methods: In 57 patients (28 HP+ve, 29 HP-ve) antrum and corpus biopsies were analysed for HP-density, inflammatory changes and immunostaining for PCNA, Ki-67, bcl-2 oncoprotein, beta-H+, K+ATP-ase, gastrin and somatostatin.In the antrum and corpus five gastric mucosal glands were divided for analysis into upper, middle and lower section.Results were expressed as gastritis score, mean values of labelling index (U) and density of specific cells.Results: In contrast to the antrum, there was a significant correlation between PCNA U and Ki-67 U and the gastrtis score (p-O.03;pO.0018) in the corpus.This also applied to the relation between Ki-67 U and the HP-density in corpus glands (r-0.32;p.O.04).Bcl-2 positive epithelial cells were seen in antrum and corpus but predominantly in HP-ve cases.H+, K+ATP-ase positive panetal cells were reduced in gastc corpus as a function of disease severity, antral G-and D-cells, in relation to degree of HP-density.Concluslon: Our data sugest that HP-induced corpus, but not antral gastritis is in a state of hyperproliferation.Upregulation of bcl-2 may protect epithelial cells from programmed cell death in gastritis.Prolonged hyper proliferation and reduced apoptosis of the gastric epithelium exerted by HP- infection could be a major contributing factor for human gastric carcinogenesis.Homeostasis of antral G-and D-cells appears to be directy governed by HP whereas loss of parietal cells is more a function of the degree of gastritis.
Practice of venous thromboembolism (VTE) prophylaxis in hospitalized cancer patients at a comprehensive cancer center.
Authors: Maria Alma Rodriguez, Alma Yvette DeJesus, Lee Cheng, Michael Kroll
Journal: Journal of Clinical Oncology (2014)

6626 Background: VTE prophylaxis measures are endorsed by the National Quality Forum in alignment with quality indicators from the Centers for Medicare and Medicaid Services. Accordingly, documentation of VTE risk, prophylaxis measures, and contraindications are recommended for hospitalized patients. To standardize practice we embedded a VTE risk assessment and prophylaxis module into admission and post-surgical order sets (OS), starting August 15, 2011. Methods: A retrospective study of 9,065 cancer patients (≥18 years) admitted to The University of Texas MD Anderson Cancer Center between June 01, 2013, through September 30, 2013. Pharmacological prophylaxis was executed with low-molecular-weight heparin or unfractionated heparin. Mechanical prophylaxis was executed with graduated compression stockings and/or sequential compression devices. Chi-square testing was used to determine the association between categorical variables. Results: 7,366 (81%) of all hospital admissions had documented VTE risk assessment and prophylaxis through the standardized VTE module. Before implementation of the new OS, only 40% of eligible patients received an order for VTE prophylaxis. The majority of patients were designated high or moderate risk (91.1%). Patients with high risk were more likely to receive pharmacological prophylaxis than those with moderate risk (74.1% vs. 38.2%, P<0.01). The most frequent contraindications to pharmacological prophylaxis were major surgery with risk of bleeding and thrombocytopenia. Results are shown in Table. Conclusions: Most patients received VTE prophylaxis based on VTE risk levels presented in a standardized OS. Because there is limited information in the clinical literature about the impact of VTE prophylaxis on outcomes among cancer patients, we plan to monitor and analyze anticoagulation-related outcomes as well as mortality and morbidity related to thrombosis and bleeding in this cohort of patients. VTE risk assessment and prophylaxis (n=7,366). VTE risk level No (%) % of prophylaxis Pharmacological Pharmacological contraindication Mechanical High 1,021 (13.9%) 74.1 20.1 99.7 Moderate 5,689 (77.2%) 38.2 56.3 35.4 Low 656 ( 8.9%) N/A N/A 97.6
Abstract 573: Mutations found by targeted next generation sequencing is associated with intra-tumor immune profile and may predict response to anti-PD1 therapy in lung adenocarcinoma
Authors: Audrey Lupo, Jerome Biton, Marco Alifano, Diane Damotte, Jennifer Arrondeau, Pascaline Boudou, François Goldwasser, Karen Leroy, Marie Wislez, Pierre Laurent-Puig, Isabelle Cremer, Helène Blons, Ronald Herbst
Journal: Cancer Research (2019)

Abstract Purpose: the immune environment of cancer is the target of immunotherapies with programmed cell death 1 (PD-1) therapeutic antibodies. However, factors that can robustly predict long-lasting responses are still needed. Previous studies showed a role of cancer cells on immune response setting, but the impact of somatic mutations on the composition of the immune stroma is not fully characterized. Experimental Design: We characterized the immune profile of 221 lung adenocarcinomas using immunohistochemistry (CD8 T cells, Macrophages, neutrophils, PD-L1) and compare to tumor mutational status using targeted next-generation sequencing. The response to PD-1 blockers was analyzed from a prospective cohort of 31 lung carcinomas according to tumor mutational profiles and to tumor cell PD-L1 expression. Results: We report that distinct combinations of STK11, EGFR and TP53 mutations, allows the identification of immune cells combination and prediction of PD-L1 expression on tumor cells. Lung adenocarcinomas with the highest CD8 T cell density and PD-L1 expression were those with TP53 mutations without co-occurring STK11or EGFR alterations (TP53-mut/STK11-EGFR-WT), and independently of KRAS status. Interestingly in TP53-mut/STK11-EGFR-WT tumors, pathways related to T cell chemotaxis, immune cell cytotoxicity, and antigen processing were up-regulated. In accordance with these results we found a prolonged progression-free survival (PFS: HR=0.32; 95% CI, 0.16-0.63, p&amp;lt;0.001) in anti-PD-1 treated patients harboring TP53-mut/STK11-EGFR-WT tumors. This clinical benefit was even more remarkable in patients with associated strong PD-L1 expression. Conclusions: Our study reveals that mutations in lung adenocarcinoma impact intra-tumor immune profile and predict response to PD-1 blockade. Citation Format: Audrey Lupo, Jerome Biton, Marco Alifano, Diane Damotte, Jennifer Arrondeau, Pascaline Boudou, François Goldwasser, Karen Leroy, Marie Wislez, Pierre Laurent-Puig, Isabelle Cremer, Helène Blons, Ronald Herbst. Mutations found by targeted next generation sequencing is associated with intra-tumor immune profile and may predict response to anti-PD1 therapy in lung adenocarcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 573.
Diagnosis and therapy of common myofascial syndromes
Authors: B. R. Brown
Journal: JAMA (1978)

PHYSICIANS commonly are faced with cervical and lumbar pain problems from antecedent trauma, muscular tension, or postural abnormalities. The common denominator of these conditions is skeletal muscle and ligamentous strain. Pain originating from lesions in these structures, regardless of anatomic localization, has been termed "primary myofascial syndrome." Paramount to the diagnosis of myofascial syndrome is the absence of demonstrable neurologic or orthopedic deficits. In fact, this constellation of pain problems frequently mimics conditions such as herniated cervical and lumbar disks, facet syndromes, fractured transverse processes, thoracic outflow syndrome, and spondylolisthesis. Obviously, therapy for these latter diagnoses is different from that for primary myofascial syndrome, and attention should be given to ruling out such surgically correctable lesions by evaluation of past history, adequate physical examination, and appropriate laboratory and roentgenographic studies. More than 500 cases of primary myofascial syndrome have been diagnosed and treated in the past six years at the
Lullaby
Authors: John Arun Mukand
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Die Therapie an den Berliner Universitäts-Kliniken.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
STUDIES ON THE CHEMOTHERAPY OF THE HUMAN MALARIAS. II. METHOD FOR THE QUANTITATIVE ASSAY OF SUPPRESSIVE ANTIMALARIAL ACTION IN FALCIPARUM MALARIA 123
Authors: David P. Earle, Robert W. Berliner, John V. Taggart, William J. Welch, Charles G. Zubrod, Nancy Bowman Wise, Thomas C. Chalmers, Roger L. Greif, James A. Shannon
Journal: Journal of Clinical Investigation (1948)
Addition of an Omitted Word
Authors: Caroline Meade, Connor Drake, Ralph Snyderman
Journal: JAMA (2016)

its goal of substantially improving the nation's health without changes in how care is delivered.Health care continues to be financially incentivized to deliver expensive specialty care for the sporadic treatment of disease rather than health promotion and effective primary and secondary prevention.As a consequence, the burden of preventable chronic diseases continues to rise.Accountable care organizations were created to improve care delivery by encouraging comprehensive care delivery networks and by tying reimbursement to quality outcomes.Although this aspect of the ACA recognizes the need to deliver quality care that improves health outcomes, accountable care organizations currently provide care for only 8.9% of the population 2 and changes in reimbursement to reward better outcomes have been slow.Rational delivery models to provide personalized, preventive, and participatory care, such as personalized health care 3,4 and other evidencebased approaches developed through funding by the Patient-Centered Outcomes Resource Institute, 5 will not be embraced by health care systems until reimbursement supports their adoption.The benefits that could be provided by the implementation of proactive and patient-centered delivery models are thus stifled by the financial losses that they would incur within the current fee-for-service payment model.Therefore, improvements the ACA has made by expanding coverage may not result in better health until significant progress is made in value-based reimbursement.We believe that supporting care delivery reform to prevent disease and improve health outcomes must now become a number one priority, and reimbursement reform is needed to achieve this.Health care systems are capable of innovating and developing more effective models of care, but they will not do so until they are reimbursed appropriately.Changing the financial incentives to encourage the adoption of innovations in care could markedly expand any benefits the ACA already provides.
Gout and Kidney, Leukemia Drugs, Transfusions, 'Normal' Lungs Among Meeting Exhibits
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diseases of the Nervous System, Galveston
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CLINICAL LECTURES ON SURGERY NOW IN COURSE OF DELIVERY AT QUEEN'S COLLEGE, BIRMINGHAM
Authors: L. Parker
Journal: BMJ (1855)

GENTLEMEN,-On this occaion, I wish to direct your atten- tion to the case of S. B., who was admitted into the Queen's Hospital, with severe injuries of the head, three days ago.He is 32 years of age, and is a very athletic agricultural labourer.He was riding on the shafts of his cart in the neighbourhood of Northfield, when by some accident he fell; a hook caught him, and he was dragged QU the ground for some distance.Whether the wheels went over him, it is difficult to say.When he was ad- mitted, it was found that the skin over the right temple was divided to the extent of five or six inches.The tem- poral muscle was also cut through-a pretty clean cut.On putting the finger to the bottom of the wound thus made, a fracture of the skull was detected in the squa- mous portion of the temporal bone.This was a fracture of the skull.There was also a long scalp wound, and a division of the temporal muscle, as I have said.In addition to this, he had fracture of the sixth and seventh ribs, and fracture of the second rib near the sternum, with a wound of the lung, for the whole surface of the chest was emphysematous.Such were the conditions of injur under which this poor man laboured.Now we wil examine his symptoms seriatim, and we will take for this purpose the dresser's (Mr. Williams) note of the case, which is a very good one, and make com- ments as we go on.CASi.When he was admitted, he was suffering from the effects of shock; the skin was cold, the pulse small, frequent, and unsteady, and the pupils dilated; he vomited and passed two motions involuntarily.There was a condition approaching that of coma; but if you roused
Neonatal Death From Congestive Heart Failure Associated With Large Cutaneous Cavernous Hemangioma
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diseases of Infancy and Childhoold: Their Dietetic, Hygienic and Medical Treatment. A Text-Book Designed for Practitioners and Students in Medicine.
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal