tbuckley/cabot-search huggingface dataset:
Redox Regulation in Cancer Cells during Metastasis
Authors: Alpaslan Tasdogan, Jessalyn M. Ubellacker, Sean J. Morrison
Journal: Cancer Discovery (2021)

Abstract Metastasis is an inefficient process in which the vast majority of cancer cells are fated to die, partly because they experience oxidative stress. Metastasizing cancer cells migrate through diverse environments that differ dramatically from their tumor of origin, leading to redox imbalances. The rare metastasizing cells that survive undergo reversible metabolic changes that confer oxidative stress resistance. We review the changes in redox regulation that cancer cells undergo during metastasis. By better understanding these mechanisms, it may be possible to develop pro-oxidant therapies that block disease progression by exacerbating oxidative stress in cancer cells. Significance: Oxidative stress often limits cancer cell survival during metastasis, raising the possibility of inhibiting cancer progression with pro-oxidant therapies. This is the opposite strategy of treating patients with antioxidants, an approach that worsened outcomes in large clinical trials.
EDEMA AND ASCITES FORMATION
Journal: JAMA (1946)

After the first world war, edema which was associated with severe undernutrition became widely apparent in Europe. Absence of a renal or cardiac cause for this disorder caused demonstrable hypoproteinemia to be considered the etiologic factor. Reduction of the serum protein reduced the colloidal osmotic pressure of the blood to such an extent that the balance between osmotic pressure and filtration pressure in the capillaries was overcome; this resulted in the accumulation of fluid in the tissues. Famine edema can be produced in animals by keeping them on a low protein diet, causing a reduction in plasma protein concentration. Thus the relation of reduced plasma protein concentration to edema seems well established. Recently Keys and his associates<sup>1</sup>studied malnutrition in a large number of healthy men who were kept for six months on a severely deficient diet consisting mainly of food from plant sources and providing 49 Gm. of
Sensitization to Nickel Associates with HLA-DR53 (DRB4*01) in Implant Failure Patients; the Association is Confirmed in a DR53 Transgenic Mouse Model
Authors: Wei Li, Lan Chen, Yan Zhang, Stephanie Devoe, Tina Roark, Kirsten Anderson, Brian Freed, Lisa Barker, Shaodong Dai, Karin Pacheco
Journal: Journal of Allergy and Clinical Immunology (2022)
Inhibition of endoplasmic reticulum stress signaling rescues cytotoxicity of human apolipoprotein-L1 risk variants in Drosophila
Authors: Lea Gerstner, Mengmeng Chen, Lina L. Kampf, Julian Milosavljevic, Konrad Lang, Ronen Schneider, Friedhelm Hildebrandt, Martin Helmstädter, Gerd Walz, Tobias Hermle
Journal: Kidney International (2022)
Cell-Based Microfluidic Device Utilizing Cell Sheet Technology
Authors: Katsuhisa Sakaguchi, Kei Akimoto, Masanori Takaira, Ryu-ichiro Tanaka, Tatsuya Shimizu, Shinjiro Umezu
Journal: Cyborg and Bionic Systems (2022)

The development of microelectromechanical systems has resulted in the rapid development of polydimethylpolysiloxane (PDMS) microfluidic devices for drug screening models. Various cell functions, such as the response of endothelial cells to fluids, have been elucidated using microfluidic devices. Additionally, organ-on-a-chip systems that include organs that are important for biological circulation, such as the heart, liver, pancreas, kidneys, and brain, have been developed. These organs realize the biological circulation system in a manner that cannot be reproduced by artificial organs; however, the flow channels between the organs are often artificially created by PDMS. In this study, we developed a microfluidic device consisting only of cells, by combining cell sheet technology with microtitanium wires. Microwires were placed between stacked fibroblast cell sheets, and the cell sheets adhered to each other, after which the microwires were removed leaving a luminal structure with a size approximately equal to the arteriolar size. The lumen structure was constructed using wires with diameters of 50, 100, 150, and 200
G20's Initiative for Early Childhood Development
Authors: Linda M Richter, Chris Desmond, Jere Behrman, Pia Britto, Bernadette Daelmans, Amanda E Devercelli, Paul Gertler, John Hoddinott, Wafaie Fawzi, Günther Fink, Joan Lombardi, Florencia Lopez Boo, Chunling Lu, Stephen Lye, Milagros Nores, Aisha Yousafzai
Journal: The Lancet (2018)
<i>Lactobacillus rhamnosus</i> CNCM I-3690 decreases subjective academic stress in healthy adults: a randomized placebo-controlled trial
Authors: Lucas Wauters, Luka Van Oudenhove, Alison Accarie, Karlien Geboers, Hannelore Geysen, Joran Toth, Anja Luypaerts, Kristin Verbeke, Tamara Smokvina, Jeroen Raes, Jan Tack, Tim Vanuytsel
Journal: Gut Microbes (2022)

Psychological stress negatively affects the intestinal barrier function in animals and humans. We aimed to study the effect of Lactobacillus rhamnosus CNCM I-3690 on intestinal permeability and stress-markers during public speech. Healthy students were randomized to L. rhamnosus-containing (test) or acidified (placebo) milk consumed twice daily for 4 weeks, with 46 subjects per treatment group. Small intestinal permeability was quantified by a 2 h urinary lactulose-mannitol ratio (LMR, primary outcome), fractional excretion of lactulose (FEL) and mannitol (FEM). Salivary cortisol, State-Trait Anxiety Inventory (STAI) and Perceived Stress scores (PSS) were collected. No between-treatment differences were found for LMR (p = .71), FEL or FEM. Within-treatment analyses showed similar LMR and FEL but a stress-induced increase of FEM with the placebo (p < .05) but not test product. Despite a similar increase in salivary cortisol, the stress-induced increase in STAI was significantly lower with the test product vs. placebo (p = .01). Moreover, a stress-preventative effect of the probiotic was found for PSS and more pronounced in subjects with high stress-induced cortisol (p = .01). While increased FEM was mediated by salivary cortisol levels, the effect of the test product on subjective stress was not mediated by changes in FEM. No serious adverse events occurred. In conclusion, we demonstrated that L. rhamnosus CNCM I-3690 prevented stress-induced hyperpermeability to mannitol. Subjective but not objective stress-markers were reduced with L. rhamnosus vs. placebo, suggesting anxiolytic effects, which were independent of barrier stabilization and attractive for the reduction of stress in both health and disease. Clinicaltrials.gov, number NCT03408691.
Mental health symptoms in family members of COVID-19 ICU survivors 3 and 12 months after ICU admission: a multicentre prospective cohort study
Authors: Hidde Heesakkers, Johannes G. van der Hoeven, Stijn Corsten, Inge Janssen, Esther Ewalds, Dominique Burgers-Bonthuis, Thijs C. D. Rettig, Crétien Jacobs, Susanne van Santen, Arjen J. C. Slooter, Margaretha C. E. van der Woude, Marieke Zegers, Mark van den Boogaard
Journal: Intensive Care Medicine (2022)

Long-term mental outcomes in family members of coronavirus disease 2019 (COVID-19) intensive care unit (ICU) survivors are unknown. Therefore, we assessed the prevalence of mental health symptoms, including associated risk factors, and quality of life (QoL) in family members of COVID-19 ICU survivors 3 and 12 months post-ICU.A prospective multicentre cohort study in ICUs of ten Dutch hospitals, including adult family members of COVID-19 ICU survivors admitted between March 1, and July 1, 2020. Symptom prevalence rates of anxiety, depression (Hospital Anxiety and Depression Scale) and Post-Traumatic Stress Disorder (Impact of Event Scale-6), and QoL (Short Form-12) before ICU admission (baseline), and after 3 and 12 months were measured. Additionally, associations between family and patient characteristics and mental health symptoms were calculated.A total of 166 out of 197 (84.3%) included family members completed the 12-month follow-up of whom 46.1% and 38.3% had mental health symptoms 3 and 12 months post-ICU, respectively; both higher compared to baseline (22.4%) (p < 0.001). The mental component summary score of the SF-12 was lower at 12-month follow-up compared with baseline [mean difference mental component score: - 5.5 (95% confidence interval (CI) - 7.4 to - 3.6)]. Furthermore, 27.9% experienced work-related problems. Symptoms of anxiety (odds ratio (OR) 9.23; 95% CI 2.296-37.24; p = 0.002) and depression (OR 5.96; 95% CI 1.29-27.42; p = 0.02) prior to ICU admission were identified as risk factors for mental health symptoms after 12 months.A considerable proportion of family members of COVID-19 survivors reported mental health symptoms 3 and 12 months after ICU admission, disrupting QoL and creating work-related problems.
Treatment by Biomarker-Informed Endotype Versus Guideline Care in Children with Difficult to Treat Asthma
Authors: Theresa Guilbert, Jocelyn Biagini, Rachelle Ramsey, Kristina Keidel, John Kroner, Sandy Durrani, Valentina Pilipenko, Lisa Martin, Carolyn Kercsmar, Kevin Hommel, Gurjit Khurana Hershey
Journal: Journal of Allergy and Clinical Immunology (2022)
Reducing high blood cholesterol levels with drugs
Authors: Judith D. Bentkover
Journal: JAMA (1991)

<h3>To the Editor.—</h3> In their cost-effectiveness analysis of alternative pharmaceutical therapies for high blood cholesterol levels, Schulman et al<sup>1</sup>do a good job of summarizing the literature relevant to a major national health goal, lowering total cholesterol and low-density lipoprotein cholesterol levels of 5% to 10% of middle-aged men in the United States plus an unidentified percentage of older men and women. However, one must be careful fully to understand the limitations of their methods before leaping to a position of advocacy concerning any programmatic policy measures that are alleged to reduce costs. First, as the authors point out in the first section of their article, serum cholesterol is used as a proxy for coronary heart disease (CHD) morbidity and mortality. Although there is no disagreement that high cholesterol levels put one at risk for an adverse CHD outcome, there is some variation in the relationship between unit or
Clinical Characteristics and Outcomes of Patients With COVID-19–Associated Acute Respiratory Distress Syndrome Who Underwent Lung Transplant
Authors: Chitaru Kurihara, Adwaiy Manerikar, Melissa Querrey, Christopher Felicelli, Anjana Yeldandi, Rafael Garza-Castillon, Kalvin Lung, Samuel Kim, Bing Ho, Rade Tomic, Ambalavanan Arunachalam, G. R. Scott Budinger, Lorenzo Pesce, Ankit Bharat
Journal: JAMA (2022)

Lung transplantation is a potentially lifesaving treatment for patients who are critically ill due to COVID-19-associated acute respiratory distress syndrome (ARDS), but there is limited information about the long-term outcome.
Duodenal Eosinophils and Mast Cells in Functional Dyspepsia: A Systematic Review and Meta-Analysis of Case-Control Studies
Authors: Ayesha Shah, Thomas Fairlie, Georgia Brown, Michael P. Jones, Guy D. Eslick, Kerith Duncanson, Nikhil Thapar, Simon Keely, Natasha Koloski, Mohit Shahi, Marjorie M. Walker, Nicholas J. Talley, Gerald Holtmann
Journal: Clinical Gastroenterology and Hepatology (2022)
Summary of conclusions of the commission on Research
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leads from the MMWR. Hepatitis B associated with jet gun injection--California
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cutaneous T‐cell lymphomas: 2021 update on diagnosis, risk‐stratification, and management
Authors: Alexandra C. Hristov, Trilokraj Tejasvi, Ryan A. Wilcox
Journal: American Journal of Hematology (2021)

Cutaneous T-cell lymphomas are a heterogenous group of T-cell neoplasms involving the skin, the majority of which may be classified as Mycosis Fungoides (MF) or Sézary Syndrome (SS).The diagnosis of MF or SS requires the integration of clinical and histopathologic data.TNMB (tumor, node, metastasis, blood) staging remains the most important prognostic factor in MF/SS and forms the basis for a "risk-adapted," multi-disciplinary approach to treatment. For patients with disease limited to the skin, expectant management or skin-directed therapies is preferred, as both disease-specific and overall survival for these patients is favorable. In contrast, patients with advanced-stage disease with significant nodal, visceral or blood involvement are generally approached with systemic therapies, including biologic-response modifiers, histone deacetylase inhibitors, or antibody-based strategies, in an escalating fashion. In highly-selected patients, allogeneic stem-cell transplantation may be considered, as this may be curative in some patients.
Results of a Phase I Study of Obinutuzumab, Venetoclax, and Lenalidomide in Relapsed and Refractory B-Cell Non-Hodgkin Lymphoma
Authors: Beth A. Christian, Ying Huang, Sabarish Ayyappan, Robert A Baiocchi, Jonathan E Brammer, Narendranath Epperla, Samantha Jaglowski, Basem M. William, Farrukh T. Awan, Kami J. Maddocks, Kristie A. Blum
Journal: Blood (2019)
P1.07-006 Altered Expression of Programmed Death-1 Receptor (PD-1) and Its Ligand PD-L1, PD-L2 after Neo-Adjuvant Chemotherapy in Lung Cancer
Authors: W. Sun, K. Ma, X. Wang, Y. Liu, H. He, Y. Guo
Journal: Journal of Thoracic Oncology (2017)
Prenatal and molecular diagnosis of hemophilia B
Authors: Ji‐Hsiung Young, Jyh‐Chwan Wang, Jyh‐Pyng Gau, Han‐Tien Hu
Journal: American Journal of Hematology (1996)

Prenatal diagnosis was carried out on a woman who had previously given birth to a son with a spontaneous mutation of C → T transition at nt 31133 of the factor IX (F.IX) gene. The diagnosis was performed on chorionic villi sampling by the method of amplification-created restriction site (ACRS). It revealed a female fetus with a normal F.IX gene, as confirmed by DNA sequencing after delivery. Meanwhile, a survey using the ACRS method to evaluate the inheritance of 63 individuals from 8 hemophilia B families was done. A different single-point mutation in each family was proved by DNA sequencing. One individual had a mutation with a naturally-created restriction site. In each of the remaining patients, we were able to show an enzyme-cutting site in their DNA amplification product for ACRS with the designed mutagenesis primers. All patients and carriers could be diagnosed accurately by comparing ACRS results with clinical and laboratory findings. There were new novel mutations among the patients. © 1996 Wiley-Liss, Inc.
Heart Transplantation
Authors: Benson B. Roe
Journal: JAMA (1988)

This comprehensive manual provides a meticulous review encompassing every aspect of cardiac transplantation in a well-organized and readable presentation. Combining his own experience in the development of a transplant program with the viewpoint of 24 other experienced contributors, Dr Myerowitz has left no stone unturned. The establishment and maintenance of a successful cardiac transplant program represent a major organizational challenge requiring the closely coordinated skills of a multidisciplined team. The list of contributors reflects expertise in anesthesia, epidemiology, immunology, pathology, tissue typing, nursing, rehabilitation, and social service as well as cardiology and cardiac surgery. Each contributor presents a readable overview of his or her respective sphere with a useful bibliography. While much of the procedural, technical, and scientific information may be familiar to the experienced cardiac surgical reader, it does provide a useful resource for other members of the team and a valuable guideline for those initiating transplant programs. Although
Evaluation of AsThma Endotypes (ELATE) Study: Rationale and Design
Authors: Elena Martín González, Paloma Poza-Guedes, Elena Mederos Luis, Javier Perez-Garcia, Raquel Suarez Lopez, Inmaculada Sanchez-Machin, Fabian Lorenzo-Diaz, Maria Pino-Yanes, Ruperto Gonzalez Perez
Journal: Journal of Allergy and Clinical Immunology (2022)
A mechanism for hereditary angioedema caused by a lysine 311–to–glutamic acid substitution in plasminogen
Authors: S. Kent Dickeson, Sunil Kumar, Mao-Fu Sun, Bassem M. Mohammed, Dennis R. Phillips, James C. Whisstock, Adam J. Quek, Edward P. Feener, Ruby H. P. Law, David Gailani
Journal: Blood (2022)
Serum interferon-α levels and IFN type I-stimulated genes score perform equally to assess systemic lupus erythematosus disease activity
Authors: François Chasset, Alexis Mathian, Karim Dorgham, Camillo Ribi, Marten Trendelenburg, Uyen Huynh-Do, Pascale Roux-Lombard, Delphine Sophie Courvoisier, Zahir Amoura, Guy Gorochov, Carlo Chizzolini
Journal: Annals of the Rheumatic Diseases (2022)

à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
Pembrolizumab induces HIV latency reversal in people living with HIV and cancer on antiretroviral therapy
Authors: Thomas S. Uldrick, Scott V. Adams, Remi Fromentin, Michael Roche, Steven P. Fling, Priscila H. Gonçalves, Kathryn Lurain, Ramya Ramaswami, Chia-ching Jackie Wang, Robert J. Gorelick, Jorden L. Welker, Liz O’Donoghue, Harleen Choudhary, Jeffrey D. Lifson, Thomas A. Rasmussen, Ajantha Rhodes, Carolin Tumpach, Robert Yarchoan, Frank Maldarelli, Martin A. Cheever, Rafick Sékaly, Nicolas Chomont, Steven G. Deeks, Sharon R. Lewin
Journal: Science Translational Medicine (2022)

In people living with HIV (PLWH) on antiretroviral therapy (ART), virus persists in a latent form where there is minimal transcription or protein expression. Latently infected cells are a major barrier to curing HIV. Increasing HIV transcription and viral production in latently infected cells could facilitate immune recognition and reduce the pool of infected cells that persist on ART. Given that programmed cell death protein 1 (PD-1) expressing CD4 + T cells are preferentially infected with HIV in PLWH on ART, we aimed to determine whether administration of antibodies targeting PD-1 would reverse HIV latency in vivo. We therefore evaluated the impact of intravenous administration of pembrolizumab every 3 weeks on HIV latency in 32 PLWH and cancer on ART. After the first infusion of anti–PD-1, we observed a median 1.32-fold increase in unspliced HIV RNA and 1.61-fold increase in unspliced RNA:DNA ratio in sorted blood CD4 + T cells compared to baseline. We also observed a 1.65-fold increase in plasma HIV RNA. The frequency of CD4 + T cells with inducible virus evaluated using the tat/rev limiting dilution assay was higher after 6 cycles compared to baseline. Phylogenetic analyses of HIV env sequences in a participant who developed low concentrations of HIV viremia after 6 cycles of pembrolizumab did not demonstrate clonal expansion of HIV-infected cells. These data are consistent with anti–PD-1 being able to reverse HIV latency in vivo and support the rationale for combining anti–PD-1 with other interventions to reduce the HIV reservoir.
Dry Eye Disease
Authors: Farida E. Hakim, Asim V. Farooq
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Phase II, Open-Label Study of Bortezomib (Velcade®), Cladribine, and Rituximab (VCR) in Advanced, Newly Diagnosed and Relapsed/Refractory Mantle Cell and Indolent Lymphomas
Authors: Abhijeet Kumar, Jose Guillen-Rodriguez, Jonathan H. Schatz, Lora Inclan, Alfonso E Ayala, Xavier Rivera, Srinath Sundararajan, Faiz Anwer, Daruka Mahadevan, Daniel O. Persky, Soham D. Puvvada
Journal: Blood (2016)
PLoS Medicine Issue Image | Vol. 5(1) January 2008
Journal: PLoS Medicine (2008)

A study in this month's issue aims to quantify the combined impact of four key healthy behaviors on mortality in men and women in the United Kingdom: not smoking; not being physically inactive; drinking alcohol moderately; and, as represented by our image, having a blood vitamin C level consistent with a fruit and vegetable intake of five servings a day (Khaw, et al. e12). The estimated impact of 14 additional years of life as a result of these behaviors suggests that modest and achievable lifestyle changes can have a marked effect on the health of populations. However, as this month's editorial discusses with reference to previous PLoS Medicine papers on urban safety and physical activity in the United States (Bennett, et al. e306) and food insecurity and high-risk sexual behaviour in Botswana (Weiser, et al. e260), individuals in isolation often cannot make the lifestyle changes they want, and a set of complex processes govern the translation of research into public health outcomes. Image Credit: Image by Umberto Salvagnin (http://www.flickr.com/photos/kaibara/)