POS1102 TEMPORAL TRENDS AND FACTORS ASSOCIATED WITH VITAMIN D PRESCRIPTION AND INTAKE
Authors: G. Adami, D. Gatti, O. Viapiana, P. Olivi, F. Bertoldo, A. Fassio, M. Rossini
Journal: Annals of the Rheumatic Diseases (2021)

Background: Vitamin D has proven skeletal effects and its administration is recommended in patients with osteoporosis by many national and international guidelines. Nevertheless, the compliance to treatment of patients with osteoporosis is scarce. Understanding the factors associated with low vitamin D intake and prescription might help design future intervention aimed to improve adherence. Objectives: This study aims to investigate the temporal trends and factors associated with vitamin D prescription and intake. Methods: Using a web-based fracture risk-assessment tool, we collected demographic, densitometric and clinical data of women at high risk for fractures. To determine the factors associated with low vitamin D intake we ran a multivariable logistic regression analysis. We described the public general interest in the term “vitamin D” using the Google Trends tool. Results: 12,419 women were included in the study. 6,748 (54.4%) individuals had a prevalent fragility fracture and 8,950 (72.1%) individuals were on &lt;800 IU of vitamin D per day and 11,434 (92.1%) were taking &lt;1,200 IU of vitamin D per day. The factors associated with vitamin D intake were evaluated with a multivariable logistic regression analysis, which results are presented in Table 1. We found that low BMD levels, the presence of associated comorbidities and glucocorticoid utilization were associated with greater vitamin D intake. Falls were associated only with lower risk of receiving very low dose of vitamin D (&lt;250 IU day). Smoking status was associated with lower vitamin D intake. Overall, the internet interest in vitamin D was higher during the winter season Figure 1. Figure 1. Google trends interest in the term “vitamin D” from January 2010 to October 2020 Conclusion: Low vitamin D intake (&lt;800 IU day) was common in our cohort of women at high risk for fractures. The factors associated with greater vitamin D intake were: having low BMD levels, associated rheumatic diseases and glucocorticoid use. Falls were associated with lower risk of receiving very low dose of vitamin D (&lt;250 IU day). Smoking status was associated with lower vitamin D intake. Table 1. Binary logistic regression to predict the risk of low vitamin D intake (&lt;800 IU/day) &gt;800 IU day REF aOR (95% CI) p value 400-800 IU day Age 1.001 (0.995-1.007) NS T-score 1.422 (1.342-1.508 ) &lt;0.001 No comorbidities REF Rheumatoid arthritis 0.732 (0.583-0.920 ) &lt;0.001 Psoriatic arthritis 0.362 (0.218-0.607 ) &lt;0.001 Connective tissue disease 0.630 (0.486-0.816 ) &lt;0.001 No cigarette smoking REF Cigarette smoking 1.040 (0.893-1.212) NS Alcohol &lt;3 unit day REF Alcohol ≥3 unit day 1.201 (0.660-2.187) NS No glucocorticoids REF Glucocorticoids 2.5-5 mg/day 0.688 (0.550-0.860 ) &lt;0.001 Glucocorticoids ≥5 mg/day 0.739 (0.554-0.986 ) &lt;0.001 No falls REF Falls 0.875 (0.754-1.015) NS 250-400 IU day Age 0.994 (0.985-1.002) NS T-score 1.223 (1.117-1.339 ) &lt;0.001 No comorbidities REF Rheumatoid arthritis 0.670 (0.463-0.970 ) &lt;0.001 Psoriatic arthritis 0.300 (0.119-0.752 ) &lt;0.001 Connective tissue disease 0.651 (0.435-0.975 ) &lt;0.001 No cigarette smoking REF Cigarette smoking 1.371 (1.104-1.702 ) &lt;0.001 Alcohol &lt;3 unit day REF Alcohol ≥3 unit day 1.824 (0.865-3.887) NS No glucocorticoids REF Glucocorticoids 2.5-5 mg/day 0.930 (0.666-1.297) NS Glucocorticoids ≥5 mg/day 0.743 (0.464-1.189) NS No falls REF Falls 0.934 (0.741-1.176) NS &lt;250 IU day Age 0.993 (0.988-0.998 ) &lt;0.01 T-score 1.139 (1.079-1.202 ) &lt;0.001 No comorbidities REF Rheumatoid arthritis 0.645 (0.522-0.795 ) &lt;0.001 Psoriatic arthritis 0.553 (0.376-0.812 ) &lt;0.001 Connective tissue disease 0.697 (0.558-0.871 ) &lt;0.001 No cigarette smoking REF Cigarette smoking 1.339 (1.171-1.532 ) &lt;0.001 Alcohol &lt;3 unit day REF Alcohol ≥3 unit day 1.267 (0.749-2.145) NS No glucocorticoids REF Glucocorticoids &lt;5 mg/day 0.964 (0.796-1.168) NS Glucocorticoids ≥5 mg/day 0.946 (0.736-1.215) NS No falls REF Falls 0.615 (0.530-0.712 ) &lt;0.001 Disclosure of Interests: None declared.