tbuckley/cabot-search huggingface dataset:
126P Clinical predictive factors in real world setting in advanced non-small cell lung cancer (NSCLC) patients (pts)treated with immune checkpoint inhibitors (ICI)
Authors: A. Callejo, D. Marmolejo, P. Iranzo, J.D. Assaf, N. Pardo, A. Navarro, A. Martinez-Marti, S. Cedres, N.M. Diaz Mejia, C. Carbonell, R. Amat, J. Frigola, E. Felip
Journal: Journal of Thoracic Oncology (2021)
Production of platelet-activating factor by human vascular endothelial cells: evidence for a requirement for specific agonists and modulation by prostacyclin.
Authors: G AZimmerman, T MMcIntyre, S MPrescott
Journal: Circulation (1985)

Primary cultures of confluent endothelial cells derived from human umbilical veins produce platelet-activating factor (PAF) (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when stimulated with appropriate agonists. Highly purified human thrombin and calcium ionophore A23187 stimulate the incorporation of [3H] acetate into a lipid product that has been identified as PAF by its behavior in thin-layer chromatographic and high-performance liquid chromatographic systems, the presence of characteristic biologic activity, and appropriate response to phospholipases. A number of other humoral mediators, examined because they directly influence the activity of vascular cells or because they may mediate endothelial injury, do not stimulate PAF production by endothelial cells. This indicates that the synthesis of PAF by cultured human endothelial cells is a response to specific agonists and is not an unregulated event that occurs as a result of nonspecific cellular perturbation. The PAF produced by thrombin-treated en...
Assessment of cardiac performance with quantitative radionuclide angiocardiography. Effects of oral propranolol on global and regional left ventricular function in coronary artery disease.
Authors: R CMarshall, H JBerger, L AReduto, L SCohen, AGottschalk, B LZaret
Journal: Circulation (1978)

The effect of incremental dosages of oral propranolol (mean peak dose of 165 +/- 13 mg/day) of left ventricular ejection fraction, ejection rate and regional wall motion was studied sequentially in 22 stable, resting patients with coronary artery disease using a geometry-independent first-pass radionuclide angiocardiographic technique. All patients improved clinically, in association with a fall in heart rate and therapeutic serum propranolol levels. No significant changes were noted in ejection fraction, ejection rate or regional wall motion. No patient developed a new regional wall motion disturbance. Thus, oral propranolol administered at clinically effective antianginal dosages in patients with stable coronary artery disease does not appear to have significant deleterious effects on resting left ventricular performance.
Capsule Endoscopy Findings Reflect the Gastrointestinal Conditions in Patients With Systemic Scleroderma
Authors: S Iio, S Oka, S Tanaka, A Sumioka, A Tsuboi, T Nojima, S Hirata, Y Matsuo, E Sugiyama, M Hide, K Arihiro, K Chayama
Journal: Endoscopy (2021)

Aims Systemic scleroderma (SSc) is characterized by chronic progressive systemic organ fibrosis. However, frequency and characteristics of small-bowel lesions in SSc patients are still unclear. This study aimed to evaluate the clinical state of SSc patients using capsule endoscopy (CE).
Beneficial effects of colestipol-niacin therapy on the common carotid artery. Two- and four-year reduction of intima-media thickness measured by ultrasound.
Authors: D HBlankenhorn, R HSelzer, D WCrawford, J DBarth, C RLiu, C HLiu, W JMack, PAlaupovic
Journal: Circulation (1993)

BACKGROUNDControlled clinical trials have reported treatment effects evaluated with serial imaging in coronary and femoral but not cervical arteries. The Cholesterol Lowering Atherosclerosis Study, a coronary, cervical, and femoral angiographic trial of colestipol plus niacin, included a pilot study of standardized carotid ultrasound imaging.METHODS AND RESULTSSeventy-eight subjects had ultrasound studies at baseline, 2, and 4 years. Twenty-four drug and 22 placebo subjects had carotid ultrasound images at baseline, 2, and 4 years with matching cervical angiograms. Computer image processing was applied to ultrasound images of common carotid (far wall) and cervical angiograms. Computer operators were blind to treatment group. Carotid ultrasound measurements were tested for treatment effects and compared with measurements of atherosclerosis in coronary and cervical angiograms. Drug subjects showed significant progressive reduction in carotid thickness at 2 (P = .0001) and 4 years (P = .0001); placebo subjec...
A mechanism of torsades de pointes in a canine model.
Authors: G HBardy, R MUngerleider, W MSmith, R EIdeker
Journal: Circulation (1983)

A dog model of torsades de pointes (TdP) was developed. Twenty 18-30-kg dogs had cardiopulmonary bypass instituted to maintain stable temperature, perfusion pressure and oxygenation. Quinidine, 30 mg/kg, was then administered and burst ventricular pacing was used to induce arrhythmias. The left anterior descending coronary artery was occluded for 15 minutes and repeat pacing studies were performed. Maps of epicardial activation were made from 27 simultaneously recorded electrograms obtained from 1-mm bipolar electrodes secured to the epicardium with a nylon mesh sock. Arrhythmias in five dogs met criteria for the diagnosis of TdP: All had the characteristic undulating QRS morphology typically associated with TdP, all occurred in the setting of QT prolongation and all ended spontaneously. The epicardial maps demonstrated that each change in QRS morphology was associated with a change in the site of epicardial breakthrough. Those QRS complexes during the transition from one morphology to the next were assoc...
Distribution and functional significance of cardiac angiotensin converting enzyme in hypertrophied rat hearts.
Authors: HSchunkert, BJackson, S STang, F JSchoen, J FSmits, C SApstein, B HLorell
Journal: Circulation (1993)

BACKGROUNDThe intracardiac conversion rate of angiotensin (Ang) I to Ang II and the expression of angiotensin converting enzyme (ACE) mRNA are amplified in rat hearts with left ventricular hypertrophy (LVH). To examine whether the accelerated intracardiac Ang II generation in LVH is related to an induction of cardiac ACE, we studied localization and function of cardiac ACE in hypertrophied rat hearts using specific ACE inhibitors.METHODS AND RESULTSCardiac ACE was localized and quantified in hearts from male Wistar rats with LVH due to chronic experimental aortic stenosis and from control rats. With the ACE inhibitor 125I-351A, a derivative of lisinopril, as a radioligand on coronal sections of LVH and control hearts, in vitro autoradiography demonstrated ACE binding in aorta, coronary arteries, atria, and ventricles of both groups. Quantitative analyses revealed that ACE density (counts per minute per cross-sectional area of tissue) was twofold higher within the myocardium of hypertrophied left ventricle...
Isolated guinea pig coronary smooth muscle cells. Acetylcholine induces hyperpolarization due to sarcoplasmic reticulum calcium release activating potassium channels.
Authors: VGanitkevich, GIsenberg
Journal: Circulation Research (1990)

Smooth muscle cells, dispersed from the circumflex coronary artery of the guinea pig, were studied with the whole-cell configuration of the patch-clamp. The resting potential of about -40 mV was superimposed by spikelike hyperpolarizations (SLHs) up to -20 mV amplitude. The SLHs resulted from spontaneous transient outward currents (spontaneous TOCs) measured under voltage-clamp (-40 or -50 mV). Acetylcholine (ACh; 10 microM) increased SLHs and TOCs in amplitude and frequency. Atropine blocked the ACh effects. ACh-induced SLHs or TOCs were suppressed by bath application of tetraethylammonium (1 or 10 mM) or by cell dialysis with cesium, suggesting that they result from induction of potassium currents. In cell-attached patches, induction of currents through 130-pS potassium channels was recorded when ACh was bath-applied. An ACh-induced increase in intracellular [Ca2+] is suggested as a second messenger since SHLs and TOCs were suppressed by cell dialysis of 10 mM EGTA. ACh induced SHLs and TOCs in the abse...
Treatment of Late-Stage Syphilis
Authors: Aram S. A. van Brussel, Gijs W. D. Landman
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Guide-Wire Cannulation and Acute Post Ercp-Pancreatitis in Cases with Narrow Intrapancreatic Part of Common Bile Duct
Authors: A Steshenko, A Kiosov
Journal: Endoscopy (2021)

Aims Our research aim to determine the risk of acute pancreatitis in patients with narrow intrapancreatic part of common bile duct who had undergone endoscopic sphincterotomy in correlation with different ways of cannulation of major duodenal papilla.
3-Dimensional Versus 2-Dimensional STE for Right Ventricular Myocardial Fibrosis in Patients With End-Stage Heart Failure
Authors: Fangyan Tian, Li Zhang, Yuji Xie, Yanting Zhang, Shuangshuang Zhu, Chun Wu, Wei Sun, Meng Li, Ying Gao, Bin Wang, Jing Wang, Yali Yang, Qing Lv, Nianguo Dong, Yuman Li, Mingxing Xie
Journal: JACC. Cardiovascular imaging (2021)
The association between schizophrenia spectrum disorders and psoriasis: a large‐scale population‐based case–control study
Authors: A.F. Carvalho, M.O. Machado, E. Mallia, X. Liu, L. Eder, M. Solmi, V. Piguet, P. Kurdyak
Journal: British Journal of Dermatology (2021)

The data that support the findings of this study are from the Ontario Health Administrative held at ICES. Restrictions apply to the availability of these data, which were used under license for this study.
Exclusion of cardiac myosin heavy chain and actin gene involvement in hypertrophic cardiomyopathy of several French families.
Authors: KSchwartz, JBeckmann, CDufour, LFaure, FFougerousse, LCarrier, CHengstenberg, DCohen, H PVosberg, ASacrez
Journal: Circulation Research (1992)

Familial hypertrophic cardiomyopathy (FHC) is characterized by idiopathic myocardial hypertrophy, which often and predominantly involves the interventricular septum. The disease is transmitted as an autosomal dominant trait, and its major risk is sudden death. It was recently demonstrated that this disease is genetically heterogeneous and that in 13 of 18 unrelated families the morbid locus, termed FHC-1, maps to chromosome 14q11-12 in and/or very near the cardiac beta-myosin heavy chain gene. We have performed linkage analysis with five chromosomal markers detecting polymorphisms in either the cardiac beta-myosin heavy chain gene or the cardiac actin gene (located on chromosome 15q) on eight families from different regions of France. We show that 1) it is possible to analyze medium-sized families by using highly informative microsatellite markers located in these genes and 2) the disease is not linked to the two contractile protein genes in any of these families. Moreover, 10-20% of chromosome 14 and 20-...
Pulmonary edema during volume infusion.
Authors: LStein, J JBeraud, MMorissette, P DLuz, M HWeil, HShubin
Journal: Circulation (1975)

The relationship between left ventricular filling pressure and plasma colloid osmotic pressure to pulmonary edema was examined in a group of 37 patients, the majority of whom were hypovolemic. Sixteen patients developed pulmonary edema during fluid infusion. In the 21 patients who did not develop pulmonary edema, the left ventricular filling pressure was slightly elevated but the colloid osmotic pressure was not reduced. The majority of these patients were treated with colloid solutions (group I). In five of the 16 patients who developed pulmonary edema, the left ventricular filling pressure was elevated and there was no reduction in the plasma colloid osmotic pressure. These patients received only colloids (group II). In the other 11 patients who developed pulmonary edema, the left ventricular filling pressure was normal but the plasma colloid osmotic pressure was reduced to 16 +/- 2 torr (group III). The colloid osmotic pressure in this group was significantly less than in the other two groups (P less t...
Physiotherapy in obstetrics and gynaecology.
Authors: B Barlowe, S Harrison, D Mandelstam
Journal: BMJ (1978)

cachexia-inducing tumours are encountered in mice; a chemically induced cachexia-producing murine gastric carcinoma has been described previously.2It is suggested that the use of such tumours would avoid the complications underlying the system developed by Dr Strain and his colleagues-that is, xenografts of a human hypernephroma in immunodepressed mice.In the case of our tumours the effect of diet modification would seem to provide a valuable opening for experimental investiga- tions relevant to clinical cancer cachexia.
Myocardial lesions of progressive systemic sclerosis. A cause of cardiac dysfunction.
Authors: B HBulkley, R LRidolfi, W RSalyer, G MHutchins
Journal: Circulation (1976)

The nature, prevalence, functional significance, and indeed existence of myocardial disease in progressive systemic sclerosis (PSS) has been debated. In this study the clinical and pathological features of 52 autopsied patients were analyzed in an attempt to resolve these questions. A distinctive focal myocardial lesion ranging from contraction band necrosis to replacement fibrosis throughout both ventricular walls was present in 23 patients who had widely patent extramural coronary arteries. There were no morphologic abnormalities of the intramyocardial coronary arteries to account for these lesions. Comparing those patients having severe (13), mild (10), or no (24) PSS myocardial lesions, and patent extramural coronary arteries, there were no major differences in age, sex, frequency and severity of pulmonary, renal or hypertensive disease which could account for the myocardial necrosis and fibrosis. The three groups did differ, however, with regard to clinical cardiac abnormalities: ventricular arrhythm...
Erratum to: Single-cell whole genome sequencing reveals no evidence for common aneuploidy in normal and Alzheimer’s disease neurons
Authors: Hilda van den Bos, Diana C. J. Spierings, Aaron Taudt, Bjorn Bakker, David Porubský, Ester Falconer, Carolina Novoa, Nancy Halsema, Hinke G. Kazemier, Karina Hoekstra-Wakker, Victor Guryev, Wilfred F. A. den Dunnen, Floris Foijer, Maria Colomé-Tatché, Hendrikus W. G. M. Boddeke, Peter M. Landsdorp
Journal: Genome biology (2016)
Role of the autonomic nervous system in the release of rat submandibular gland kallikrein into the circulation.
Authors: S FRabito, T BOrstavik, A GScicli, ASchork, O ACarretero
Journal: Circulation Research (1983)

We have previously demonstrated that the rat submandibular gland releases immunoreactive kallikrein into the circulation. To study the role of the autonomic nervous system in this release, submandibular gland blood flow and kallikrein concentration in peripheral arterial and venous blood from the gland were measured and secretion rates calculated before and after parasympathetic and sympathetic nerve stimulation (8V, 2 msec, 10 Hz) for 1 minute. Immunoreactive kallikrein in plasma was measured by radioimmunoassay, and timed collections of venous outflow were used to measure blood flow. During basal conditions, the unstimulated submandibular gland of the rat released immunoreactive kallikrein into blood at the rate of 0.92 +/- 0.07 ng/min. Parasympathetic stimulation increased blood flow 4-fold (before, 68.5 +/- 8.3 microliters/min; after, 253.5 +/- 76.2; P less than 0.05) without significantly changing immunoreactive kallikrein secretion rate. Sympathetic stimulation produced an 11-fold increase in blood ...
Endoscopic Mucosal Resection of Colorectal Polyps: Results, Adverse Events and Two-Year Outcome
Authors: I Chaoui, I Demedts, P Roelandt, H Willekens, R Bisschops
Journal: Endoscopy (2021)

Aims Endoscopic mucosal resection (EMR) is the first-line treatment for large sessile and flat colorectal polyps in Western centres. However, adenoma recurrence after EMR continues to be a challenge. The aim of this study is to assess the efficacy, safety and recurrence rate of EMR in a tertiary centre and to identify risk factors associated with local recurrence during first surveillance endoscopy (SE1).
Impact of age on clinical outcome and postlytic management strategies in patients treated with intravenous thrombolytic therapy. Results from the TIMI II Study. TIMI II Investigators.
Authors: F VAguirre, R PMcMahon, HMueller, N SKleiman, M JKern, PDesvigne-Nickens, W PHamilton, B RChaitman
Journal: Circulation (1994)

BACKGROUNDFew thrombolytic studies have assessed whether patient age is an indication for routine postlytic cardiac catheterization and revascularization or evaluated the impact of age on 1-year outcome differences after acute myocardial infarction.METHODS AND RESULTSA secondary analysis of 3339 patients enrolled in the TIMI II trial was performed to identify differences in clinical and coronary angiographic findings and 1-year cardiac event rates among 841 patients < 50 years old, 1639 patients 50 to 64 years old, and 859 patients 65 to 75 years old. Differences in 1-year clinical outcome were assessed among patients randomly assigned to an invasive or a conservative postlytic strategy within each age group. The percentages of patients with a prior history of myocardial infarction, angina, congestive heart failure, hypertension, or diabetes mellitus or an infarction complicated at the time of study entry by shock, pulmonary edema, hypotension, rales more than one third of lung fields, or atrial fibrillat...
Melphalan-Induced DNA Damage In Vitro as Predictor for Clinical Outcome in Multiple Myeloma.
Authors: Meletios A. Dimopoulos, Vassilis L. Souliotis, Athanasios Anagnostopoulos, Christina Bamia, Anastasia Pouli, Ioannis Baltadakis, Evangelos Terpos, Soterios A. Kyrtopoulos, Petros P. Sfikakis
Journal: Blood (2006)
Correlation of angiographic and autopsy left ventricular dimensions in children.
Authors: E AFisher, F AEckner, I WDuBrow, A RHastreiter
Journal: Circulation (1978)

To evaluate controlled pressure coronary artery perfusion fixation of hearts as a means of obtaining meaningful cardiac measurements at autopsy, left ventricular (LV) autopsy measurements were correlated with in vivo end-diastolic (D) and end-systolic (S) angiographic (angio) values from biplane cineangiograms in the same patients. Mitral (MV) and aortic valve (AV) circumferences, LV equatorial circumference (Circ), spatial inflow and outflow lengths, wall thickness (W) and LV volume (Vol) were measured in 34 children with congenital heart disease. All dimensions showed significant correlation of angiographic and autopsy data from which linear regression equations were derived. The r values obtained were: MV 0.74; AV 0.85; D Circ 0.83; S Circ 0.82; D inflow 0.92; S inflow 0.90; D and S outflow 0.96; W 0.78; D Vol 0.92; S Vol 0.86. Mean angio and autopsy values were not significantly different for AV, S inflow, and S Vol. Autopsy values were lower than all D angio values and MV (P less than 0.001 for all),...
Adrenergic modulation of the transient outward current in isolated canine Purkinje cells.
Authors: TNakayama, H AFozzard
Journal: Circulation Research (1988)

Single canine Purkinje cells were voltage clamped under Ca2+-free conditions using the patch pipette. Depolarizing pulses from a holding potential of -42 mV induced a time-dependent rapidly activating-slowly inactivating outward current, which was identified as the transient outward current. The current showed two exponential time constants of inactivation (48,352 msec at +58 mV and 53,325 msec at +78 mV). Norepinephrine in concentrations exceeding 10(-9) M modified the inactivation kinetics of this current without affecting the activation kinetics. The half-maximum dose for norepinephrine effect was 1.9 X 10(-8) M, and the effect was saturated at 10(-6) M. Norepinephrine reduced the amplitude of the fast time constant component of inactivation, while increasing the amplitude of the slow component, without changing their time constants. Norepinephrine also increased the amplitude of a time-independent current component. The beta-antagonist sotalol blocked the norepinephrine effect on the transient outward...
Clinical pharmacology in patients with evolving myocardial infarction of tissue-type plasminogen activator produced by recombinant DNA technology.
Authors: A JTiefenbrunn, A KRobinson, P BKurnik, P ALudbrook, B ESobel
Journal: Circulation (1985)

This study was performed to characterize selected pharmacologic properties and effects on the fibrinolytic system of tissue-type plasminogen activator synthesized by recombinant DNA technology (rt-PA) in 12 patients treated for coronary thrombosis. rt-PA was infused parenterally (by the intracoronary route in four patients and intravenously in eight) in doses of 8.3, 12.5, or 16.7 micrograms/kg/min for 30 to 60 min, yielding a total dosage of 20 to 40 mg/patient. The drug induced coronary thrombolysis in 10 of the 12 patients treated (83%), including six of the eight given rt-PA intravenously. No bleeding complications were encountered. Serial blood samples were obtained before, during, and after infusion of rt-PA and analyzed for t-PA antigen (i.e., immunoassayable rt-PA protein), functional fibrinolytic activity attributable to rt-PA, fibrinogen, plasminogen, alpha 2-antiplasmin, fibrinogen degradation products, prothrombin time, activated partial thromboplastin time, and protamine-corrected thrombin ti...
Induction of coronary artery spasm by acetylcholine in patients with variant angina: possible role of the parasympathetic nervous system in the pathogenesis of coronary artery spasm.
Authors: HYasue, YHorio, NNakamura, HFujii, NImoto, RSonoda, KKugiyama, KObata, YMorikami, TKimura
Journal: Circulation (1986)

We injected acetylcholine (ACh), the neurotransmitter of the parasympathetic nervous system, into the coronary arteries of 28 patients with variant angina. Injection of 10 to 80 micrograms ACh into the coronary artery responsible for the attack induced spasm together with chest pain and ST segment elevation or depression on the electrocardiogram in 30 of the 32 arteries of the 25 of the 27 patients. The injection of 20 to 100 micrograms ACh into the coronary artery not responsible for the attack in 18 patients resulted in various degrees of constriction in most of them, but no spasm in any of them. After intravenous injection of 1.0 to 1.5 mg atropine sulfate, the injection of ACh into the coronary artery responsible for the attack did not induce spasm or attack in any of the nine coronary arteries injected in eight patients. We conclude that the intracoronary injection of ACh induces coronary spasm and attack in patients with variant angina and that the activity of the parasympathetic nervous system may ...