Long-Term Rituximab Use to Maintain Remission of Antineutrophil Cytoplasmic Antibody–Associated Vasculitis
Authors: Thomas D. Garvey, Kenneth J. Warrington, Matthew J. Koster
Journal: Annals of Internal Medicine (2020)

Letters1 December 2020Long-Term Rituximab Use to Maintain Remission of Antineutrophil Cytoplasmic Antibody–Associated VasculitisThomas D. Garvey, MD, Kenneth J. Warrington, MD, and Matthew J. Koster, MDThomas D. Garvey, MDMayo Clinic Rochester, Rochester, Minnesota (T.D.G., K.J.W., M.J.K.)Search for more papers by this author, Kenneth J. Warrington, MDMayo Clinic Rochester, Rochester, Minnesota (T.D.G., K.J.W., M.J.K.)Search for more papers by this author, and Matthew J. Koster, MDMayo Clinic Rochester, Rochester, Minnesota (T.D.G., K.J.W., M.J.K.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L20-1198 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The MAINRITSAN3 findings (1) provide much-needed and clinically applicable insight into the safety and efficacy of longer-term, lower-dose, fixed-interval dosing with rituximab in patients with AAV. However, we noted a discrepancy in the description of their clinical trial protocols that could benefit from additional clarification by the authors.Charles and colleagues state that to be eligible for inclusion in MAINRITSAN3 (1), patients had to complete the MAINRITSAN2 trial (2) without any major relapses and be in complete remission. MAINRITSAN2 compared individually tailored versus fixed-interval rituximab infusion regimens for maintenance of remission in AAV (2). However, the Methods ...References1. Charles P, Perrodeau É, Samson M, et al. Long-term rituximab use to maintain remission of antineutrophil cytoplasmic antibody-associated vasculitis. A randomized trial. Ann Intern Med. 2020;173:179-87 LinkGoogle Scholar2. Charles P, Terrier B, Perrodeau É, et al. Comparison of individually tailored versus fixed-schedule rituximab regimen to maintain ANCA-associated vasculitis remission: results of a multicentre, randomised controlled, phase III trial (MAINRITSAN2). Ann Rheum Dis. 2018;77:1143-9. [PMID: 29695500] CrossrefMedlineGoogle Scholar3. Charles P, Dechartres A, Terrier B, et al. Corrigendum to: Reducing the initial number of rituximab maintenance-therapy infusions for ANCA-associated vasculitides: randomized-trial post-hoc analysis. Rheumatology (Oxford). 2020;59:3119. [PMID: 32447394] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Mayo Clinic Rochester, Rochester, Minnesota (T.D.G., K.J.W., M.J.K.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L20-1198. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoLong-Term Rituximab Use to Maintain Remission of Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Pierre Charles , Élodie Perrodeau , Maxime Samson , Bernard Bonnotte , Antoine Néel , Christian Agard , Antoine Huart , Alexandre Karras , François Lifermann , Pascal Godmer , Pascal Cohen , Catherine Hanrotel-Saliou , Nicolas Martin-Silva , Grégory Pugnet , François Maurier , Jean Sibilia , Pierre-Louis Carron , Pierre Gobert , Nadine Meaux-Ruault , Thomas Le Gallou , Stéphane Vinzio , Jean-François Viallard , Eric Hachulla , Christine Vinter , Xavier Puéchal , Benjamin Terrier , Philippe Ravaud , Luc Mouthon , Loïc Guillevin , and Long-Term Rituximab Use to Maintain Remission of Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Pierre Charles and Loïc Guillevin Long-Term Rituximab Use to Maintain Remission of Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Siddharth Jain , Arghya Chattopadhyay , and Aman Sharma Metrics 1 December 2020Volume 173, Issue 11Page: 947-948KeywordsClinical trialsDisclosureSafetyVasculitis ePublished: 1 December 2020 Issue Published: 1 December 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...