tbuckley/cabot-search huggingface dataset:
Baseline parameters of patients with prostate cancer (PCa) initiating a triptorelin treatment for at least 12 months in real life, TALISMAN study interim analysis.
Authors: Antoine Thiery-Vuillemin, Jerome Rigaud, Gilles Crehange, Nathalie Pello Leprince Ringuet, Anne-Sophie Grandoulier, Thierry Lebret
Journal: Journal of Clinical Oncology (2022)

61 Background: Little is known on modalities of use of androgen deprivation therapy (ADT) in real life. They may depend on tumor aggressiveness, patient frailty and physician habits. Our purpose was to describe reasons of choice of planned total duration of triptorelin treatment, mainly according to circumstances of prescription. Methods: Initiated in November 2020, a prospective, multicenter, non-interventional study is conducted in France (TALISMAN). Urologists, radiation oncologists and medical oncologists recruited patients with histologically confirmed PCa, eligible for triptorelin therapy within its label, with a planned total duration of at least 12 months. Decision of triptorelin treatment was made before inclusion, in routine practice. 786 patients were planned to be enrolled, with a 12-month follow-up. Primary objective is to describe the proportion of patients treated continuously with triptorelin during the 12 months following treatment initiation. Interim analysis was planned when 50% of patients are enrolled, its objective was description of subgroups according to circumstance of prescription, planned total duration of triptorelin treatment, formulation/route of triptorelin prescribed, specialty of investigators. No statistical test was performed. Results: 509 patients were included in the interim analysis. Patients were mostly enrolled by urologists (56.8%) and radiation oncologists (40.1%). Mean age ±SD was 73.9±8.0 years; 70.9% had at least one comorbidity; 72.1% had a Gleason score ≥ 4+3; 65.2% had at least one concomitant PCa treatment. Main baseline parameters are presented in Table. Subgroups description showed that patients with high risk localized and patients with locally advanced PCa were most often offered a [24-36] month planned treatment duration (respectively 53.6% and 40.6%), in accordance with the guidelines. Reasons of choice of the planned total duration mainly refer to Gleason score (27.6%) and PSA level (19.4%). Reasons of choice of formulation/route of triptorelin prescribed mainly refer to physician preferred formulation/route (47.7%) and planned total duration of ADT (29.9%). Conclusions: The ongoing TALISMAN study is collecting data on patients, PCa aggressiveness, supportive care, which may impact total duration of triptorelin treatment. Statistical analyses at completion of study will give additional results. Clinical trial information: NCT04593420. [Table: see text]
Royal malady.
Authors: G. Dean
Journal: BMJ (1968)

February, p. 269) is to be congratulated for seeing the wood from the trees.In geriatrics this is not always easy.His clearly reasoned paper demonstrates the need for one of two things in our society of increasingly frail and dis- abled old people.Either the geriatric service must have a very much larger share of hos- pital resources-doctors, nurses, therapists, social workers, beds, and equipment-or else other clinicians will have to learn something of geriatric techniques and deal with more of their " geriatric problems."If our colleagues prefer the former, geria- tricians can cope, given proper facilities.If the latter, clinicians may be encouraged by Dr. Binks's admirable demonstration that " geriatric problems " are human and absorb- ing aspects of medicine, when approached without prejudice.-Iam, etc.,
Behaviour Therapy
Authors: R. P. Snaith
Journal: BMJ (1965)

capacity to synthesize this enzyme-though they do not entirely lack it-is not inconsistent with the Oxford report.Temporary suppressions of the already deficient enzyme, and the quantitative relationship between it and the substrate (gluten), could account for the episodic nature of multiple sclerosis;and in a population subsisting on a high gluten-containing diet the differencesbetween normal subjects and heterozygotes in remis- sion may be too subtle to be discerned by the immunological tests.-I am, etc.,
Tetanus Neonatorum
Authors: H. C. Barlow
Journal: BMJ (1948)

SIR.-May I add a few notes to the reply to the inquiry concerning pain in phantom foot ("' Any Questions ?"April 24, p. 817)?French statistics show that 72.50/' of all amputees, at least, complain of pains, most of them being phantom pains (personal statistics).In 1938 I established that such pains are greatly relieved with parenteral thiamine in a very high proportion of cases.When this quite easy method fails to give relief we perform a sympathetic ganglia "novocain ?block or a periarterial injec- tion of novocain.Intra-arterial administration of the drug sometimes relieves the pain immediately and suppresses the phantom limb sensations.At the next stage we proceed with lumbar or cervical sympathectomy, advisable in cases in which the block gives only transitory relief.The surgical treatment of the main sensitivity route (excision of the terminal neuroma, radicotomy, cordotomy) is performed in cases of failure of the above-mentioned more conservative methods.Recently some authors claimed the success of excision of the cortex, but their trials seem to remain merely in an experimental stage.Lately, psychotherapy has been introduced in the treatment of this very refractory condition.-Iam, etc.,
Cases from Private Practice
Authors: J. R. Wardell
Journal: BMJ (1848)

FITS DURING LABOUR.combination with purgatives, in cases of constipation, depending upon atony of the muscular fibres of the large intestines, or want of propelling power at tbe upper part of the rectum; but as he makes no allusion to the very asal quwtity Qf the prgative required, nor to the influence of the medicine upon the other organs supplied by the sympathetic system, &c., .1 do not think I need withhold the forgoing observations.Batb,
PERITONEAL SUPPORTS—(LIGAMENTUM PERITONEI.)
Authors: BYRON ROBINSON
Journal: JAMA (1896)

The mesentery of the sigmoid represents that which has been only partially disturbed by displacement or coalescence. The two branches of this S-iliac are a vertical primitive branch which inserts itself directly in the mid-dorsal line. This we will call the lower limb of the loop. The upper limb of the loop reaches from the lower pole of the kidney or still lower down to the point on the vertebral column where it converges with the vertical or primitive loop. The convengence of the upper and lower limbs of the sigmoid loop is on the vertebral column at a varying point according to age and individual differences. At the third fetal month, the rotating umbilical loop begins to drag on the mesentery of the descending colon. The dragging falls chiefly on a fold of the mesentery of the descending colon which may be called the ligamentum mesenterico-mesocolon, but which I
ERRATA
Journal: Journal of Clinical Investigation (1981)

Since our paper on endogenous pyrogen production by Hodgkin's disease and human histiocytic lymphoma cell lines was published (1), certain information has come to light concerning one of the cell lines used.The RY line ascribed to Hodgkin's disease derivation apparently came from a pathologically negative spleen specimen (2).It does have human chromosomes in contrast to several other imputed Hodgkin's disease lines from the same laboratory which have owl monkey karyotypes (2).The production of endogenous pyrogen by RY is not in question since supernates sent by me from New York and independently by Dr. Long from Boston were all posi- tive as assayed by Dr. Bodel in New Haven, with a number of control preparations being negative.The cell type of RY is still uncertain since it has almost no specific markers; production of lysozyme originally reported (3) has not been detected for the past three years (ref. 2 and P.R., unpublished).The other cell line producing endogenous pyrogen, U-937, is undoubtedly of monocyte lineage, as shown by several laboratories (4-6), and has human chromosomes."
ABC of major trauma. Initial assessment and management--II: Secondary survey.
Authors: P Driscoll, D Skinner
Journal: BMJ (1990)

The following scheme describes how to perform a detailed head to toe examination of the patient.In addition, it should be standard practice to perform lateral cervical spine, chest, and pelvic radiography in patients with blunt trauma.Protective lead aprons should be worn by staff who continue to manage the patient.One doctor, who may be the team leader, should be responsible for the secondary survey; the examination should be orderly and complete. Head and neck ScalpPalpate from posterior to anterior.Check for lacerations, swellings, and depressions.Palpate for fractures at the base of lacerations.Profuse bleeding of the scalp must be stopped. Extreme facial andFacial injury likely to obstruct the airway.periorbital oedema.
RECOVERY FROM UNTOWARD COMPLICATIONS OF SICKLE-CELL DISEASE
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Histamine-Fast Achlorhydria and Iron Absorption
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intracranial Metastases
Authors: P. Richards, W. McKissock
Journal: BMJ (1963)

Surgical treatment is rarely considered when an intracranial metastasis is suspected, even when the primary tumour has previously been excised.We present here a study of the 389 patients with secondary intracranial tumours seen at this hospital in the years 1946-60, inclusive, in an attempt to evaluate the possibilities for useful surgical treatment and to illustrate the unpredictable behaviour of some tumours.The cases are selected in the sense that patients with intracranial metastases are usually referred here only if the primary tumour is either unsuspected or not evident, or if several years have elapsed since excision of a primary tumour and a coincidental benign intracranial tumour has to be excluded. Criteria for DiagnosisIn this series 65% of the metastases originated from bronchogenic carcinoma (Table I).There were 213 men and 39 women.The criteria used for making the diagnosis in these cases are summarized in Table II.It will be seen that in 17% no primary tumour was detect- able on the chest film taken on admission.The other sites of origin were arrived at by histological study of the metastasis, together with previous or later histological examination of the primary in all but four cases.Professor T. Crawford reported on the histology of the great majority of the metastases.TABLE I.-Analysis of 389 Intracerebral Metastases
Traumatic Asphyxia
Authors: E. K. Gardner
Journal: BMJ (1941)

MEDICAL JOURNALoccur to an adequate degree when the drug is given by mouth only.There was much drying of the surface, but it was found better to ignore this and to maintain sterility.In the old-standing cases healing of the deep granulating areas was slow, and in these ascorbic acid was given.In comparison with similar cases without this addition healing was more rapid.Further stimulation of healing by ray treatment was not found necessary in any of this series.Sulphapyridine and sulphathiazole powders were not used: results were satisfactory with sulphanilamide powder, which was more readily obtainable.Illustrative Cases Case 1.-This patient had severe staphylococcal infection of a
Acute Bronchitis
Authors: A. B. Christie
Journal: BMJ (1951)

The English winter, " ending in July to recommence in August," affords practitioners one doubtful recompense for its ardours-namely, that all have opportunity to become closely acquainted with at least one of the com- mon conditions they are asked to treat.Fog, damp, and cold seem especially damaging to the bronchial epi- thelium, and many people in fact regard an attack of bronchitis as almost a normal winter incident, from which recovery will equally normally take place in due course.Yet acute bronchitis is not always a trivial disease.In young children and infants it is often serious, carrying a considerable mortality, and in the elderly and debilitated it may well give rise to anxiety.
Lectures on Diseases of Women and Children
Authors: C. H. F. Routh
Journal: BMJ (1862)

vent him from moving a step further until dislodged from the position which it had assumed.He stated that twenty years ago he had injured the joint by falling from a considerable height; but, after a short confinement, had experienced no inconvenience until three months ago, when he again fell from a scaffold, and two days subsequently observed the moveable body.On the 29th, the cartilage being secured over the head of the tibia, I made a free passage for its escape through the synovial membrane and cellular texture, pressed it through this track, and placed it at a little distance from the external puncture.No bad consequence followed; and on February 3rd, the fourth day after the operation, I removed the carti- lage, which was of the size of a field bean, without
Characterization of 125I-recombinant fibroblast growth factor 2 retention and distribution following direct intramyocardial injection Wendy A. Naimark, W. Michael Kavanaugh, Maria Palasis, Zhenguo Han, Susan Fischer, P. Michael Grossman, Robert J. Lederman. Boston Scientific Corporation, One Boston Scientific Place, MA, University of Michigan Health System, Ann Arbor, MI
Journal: Journal of the American College of Cardiology (2001)
Abstract 17288: Low Pulsatility is Associated With Vasoplegic Syndrome in Heartmate II LVAD Explants During Heart Transplantation
Authors: Thiru Chinnadurai, Fathima Jahufar, Edward Borukhov, Sabarivinoth Rangasamy, Omar Saeed, Sasha Vukelic, Sandhya Murthy, Julia Shin, Daniel Sims, Stephen Forest, Daniel Goldstein, Ulrich P Jorde, Snehal R Patel
Journal: Circulation (2018)

Introduction: Continuous flow-left ventricular assist devices (CF-LVAD) have been implicated as a risk factor for vasoplegic syndrome (VS) after orthotopic heart transplantation (OHT). Although a lack of pulsatility has been postulated as the cause, there is currently no data to support this hypothesis. Hypothesis: We hypothesized that low pulsatility as measured by the Pulsatility Index of HeartMate II CF-LVADs at OHT admission was associated with VS during CF-LVAD explant and OHT. Methods: A retrospective chart review of all adult patients that had underwent heart transplants at our center were reviewed from 2014-2017. VS was defined as a profound vasodilatory shock (SVR &lt; 800 dyne/s/cm 5 ) despite persistent vasopressor support with a preserved cardiac index (≥ 2.2 L/min/m 2 ) occurring at any time between 6 and 48 hours post OHT. Pulsatility Index of HeartMate II CF-LVADs were obtained at the day of OHT admission. Results: A total of 103 patients underwent OHT during the 4-year study period. The median age was 57 (48-64) years, 29 (28%) were females, 75 (73%) had CF-LVAD. Overall 23 (22%) patients developed VS. As expected, VS was more prevalent in CF-LVAD explants compared to primary heart transplant (27% vs 11%, p=0.09). Mean Pulsatility Index in CF-LVAD explants with VS (n =20/75) was lower compared to CF-LVAD explants absent VS (n=55/75) (5.9 ± 1.1 vs 6.5 ± 0.9, p=0.03) (Figure 1). Multivariate logistic regression analysis of all pre-operative variables found BMI (OR 1.23, 95% CI 1.03-1.50; p=0.01) and Pulsatility Index (OR 0.43, 95% CI 0.19-0.94; p=0.03) as the only independent risk factors associated with VS among CF-LVAD explants patients post OHT. Conclusions: In conclusion, lower pulsatility index is associated with vasoplegic syndrome in HeartMate II CF-LVAD post OHT. This association warrants further investigation in order to develop strategies to avoid this complication.
Questions and Answers
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bedside to Bench and Back: Identifying a New Clinically Relevant Driver in Pediatric Acute Myeloid Leukemia
Authors: Robert P. Hasserjian, Valentina Nardi
Journal: Blood Cancer Discovery (2022)

In this issue of Blood Cancer Discovery, Umeda and colleagues identify and comprehensively analyze a novel recurrent UBTF mutation (tandem duplications) in pediatric acute myeloid leukemia. Acute myeloid leukemia cases with UBTF tandem duplications display distinctive biologic features, including association with FLT3-ITD and WT1 mutations and high-risk disease, and appear to represent a new genetic subtype of acute myeloid leukemia. See related article by Umeda et al., p. 194 (7).
Cancer Line
Authors: Kimberly R. Myers
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial Board
Authors: Zuhair Ballas, Iowa City, Iowa Deputy, David Huston, Rachel Miller, New York, N Associate, Andrea Apter, Leonard Philadelphia, Nashville Bacharier, Claus Bachert, Joshua Boyce, Javier Chinen, Raif Geha, Johann Gudjonsson, Ann Arbor, Mich Kenji Kabashima, Corinne Keet, Carole Ober, David Peden, Harald Renz, Marburg Germany, Marc Rothenberg, Cincinnati Ohio, Hirohisa Saito, Stefan Vieths, Langen Germany, Stephan Weidinger
Journal: Journal of Allergy and Clinical Immunology (2021)
Covid-19: Mexico City gave ivermectin kits to people with covid in “unethical” experiment
Authors: Owen Dyer
Journal: BMJ (2022)

Covid-19: Mexico City gave ivermectin kits to people with covid in "unethical" experiment Owen DyerThe government of Mexico City handed out nearly 200 000 "ivermectin based kits" last year to people who had tested positive for covid-19, without telling them they were subjects in an experiment on the drug's effectiveness.
Prolonged Pregnancy
Authors: G. B. Gibson
Journal: BMJ (1955)

of gonadotrophin pointed to a pituitary origin for the testicular hypoplasia.In the cases under review, not only has the eunuchoidism to be accounted for, but also the identical skeletal deformity and the mental retardation, which is un- common in eunuchs, who are usually of normal or above normal intelligence.The three abnormalities may be explained on a single basis if the concept of a degeneration of unknown aetiology in the parental germ plasm is accepted.If the cause of the defect be a matter of heredity in the germ cells, the monovular twins should be alike-either both normal or both defective (Macklin, 1936).It is probably significant that the twins were the last of 11 preg- nancies, and at the time of their birth the ages of the father and mother were 44 and 46 years respectively.The absence of colour-blindness and anosmia from our patients strengthens the belief that the condition has arisen sporadically, as Kallman et al. (1944) concluded that these tended to be associated with eunuchoidism only when hypo- gonadism appeared as a familial trait. SummaryEunuchoidism in identical twins is described, together with mental retardation and congenital fusion of the thoracic vertebrae.Reasons are advanced for the belief that the twins are uniovular and that the condition has arisen sporadi- cally, and the opinion is also expressed that the primary cause for the abnormalities lies in an unknown degen- eration of the parental germ plasm.Our thanks are due to Dr.