tbuckley/cabot-search huggingface dataset:
Infectious disease surveillance update
Authors: Pam Das
Journal: The Lancet Infectious Diseases (2004)

The Central African Republic (CAR) has become the seventh polio-free country to have an outbreak caused by polio virus imported from Nigeria. The last paralytic polio case reported in CAR was in July 2000. This latest case follows the reporting of type 1 poliovirus spreading from Nigeria to Benin (one case), Burkina Faso (seven cases), Cameroon (one case), Chad (five cases), Ghana (eight cases), and Togo (one case). Clare Hajaj (UNICEF) told TLID that it was critical for the northern states of Nigeria to resume immunisation.
Early Conceptions and Tests of Intelligence.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From Infancy to Childhood.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Assessment of Reasons for Ownership and Attitudes About Policies Among Firearm Owners With and Without Children
Authors: Grace F. Ye, Priyanka Thatipamala, Michael Siegel
Journal: JAMA Network Open (2022)

<h3>Importance</h3> Given the dangers that firearms in the home pose to children, it is critical to engage parents in effective firearm safety counseling. This requires a broader understanding of how the presence of children in the home is associated with motivations surrounding gun ownership. <h3>Objective</h3> To examine the association of having children in the home and gun owners’ attitudes and beliefs. <h3>Design, Setting, and Participants</h3> This cross-sectional survey study analyzed data from the National Lawful Use of Guns Survey conducted in 2019. A representative sample of 3698 adult gun owners nationwide were randomly invited to participate, with a 56.5% survey response rate. Survey responses were weighted to account for survey nonresponse and selection bias, and comparison groups were matched by age. Statistical analysis was performed in 2020. <h3>Main Outcomes and Measures</h3> Reasons for gun ownership, symbolic meaning of guns, and attitudes toward gun policies. <h3>Results</h3> Of the 2086 respondents, 383 (18.4%) had children in the home, 68.7% (95% CI, 66.4%-71.0%) were male, 8.2% (95% CI, 6.8%-9.7%) were Black, 76.3% (95% CI, 73.8%-78.6%) were White, 79.4% (95% CI, 77.5%-81.2%) were living in metropolitan areas, 51.3% (95% CI, 48.9%-53.8%) identified as Republican; 34.7% (95% CI, 32.6%-36.9%) were aged 60 years or older. Despite the majority of respondents feeling safe in their local communities (respondents with children: 93.4% [95% CI,: 89.3%-96.0%]; without children: 88.9% [95% CI, 87.0%- 90.6%]), 92.3% (95% CI, 87.0%-95.6%) of respondents with children stated the primary reason for gun ownership was to protect their family, compared with 68.6% (95% CI, 65.2%-71.8%) of respondents without children. On logistic regression analysis, having children in the home remained an independent factor associated with reasons for gun ownership. Gun owners with children were more likely than those without children to feel that guns make them feel more valuable to their family (23.5% [95% CI, 18.9%-28.8%] vs 17.0% [95% CI, 15.0%-19.2%]). Among those with children, 35.2% (95% CI, 30.0%-40.8%) believed gun laws should be more strict compared with 40.7% (95% CI, 38.1%- 43.3%) of those without children. <h3>Conclusions and Relevance</h3> These findings suggest that acknowledging parental motivations for gun ownership is a pivotal component of educational efforts toward firearm injury prevention. These findings can guide clinicians to engage in effective individual counseling and community level efforts to reduce pediatric gun injuries.
DENA: training an authentic neural network model using Nanopore sequencing data of Arabidopsis transcripts for detection and quantification of N6-methyladenosine on RNA
Authors: Hang Qin, Liang Ou, Jian Gao, Longxian Chen, Jia-Wei Wang, Pei Hao, Xuan Li
Journal: Genome biology (2022)

Abstract Models developed using Nanopore direct RNA sequencing data from in vitro synthetic RNA with all adenosine replaced by N 6 -methyladenosine (m 6 A) are likely distorted due to superimposed signals from saturated m 6 A residues. Here, we develop a neural network, DENA , for m 6 A quantification using the sequencing data of in vivo transcripts from Arabidopsis. DENA identifies 90% of miCLIP-detected m 6 A sites in Arabidopsis and obtains modification rates in human consistent to those found by SCARLET , demonstrating its robustness across species. We sequence the transcriptome of two additional m 6 A-deficient Arabidopsis, mtb and fip37-4 , using Nanopore and evaluate their single-nucleotide m 6 A profiles using DENA .
Remote 6-Minute-Walk Testing in Patients with Pulmonary Hypertension: A Pilot Study
Authors: Tess LaPatra, Grayson L. Baird, Randi Goodman, Diane Pinder, Maeve Gaffney, James R. Klinger, Harold I. Palevsky, Jason Fritz, Christopher J. Mullin, Jeremy A. Mazurek, Steven M. Kawut, Corey E. Ventetuolo
Journal: American Journal of Respiratory and Critical Care Medicine (2022)

"Remote 6-Minute-Walk Testing in Patients with Pulmonary Hypertension: A Pilot Study." American Journal of Respiratory and Critical Care Medicine, 205(7), pp. 851–854
Neural networks a decision support in acute coronary syndromes Sven-Erik M. Olsson, Mattias Olsson, Hans Ohlin, Ewa Mattson, Per Sandkull, Marie-Louise Nilsson, Samir Dzaferagic, Lars Edenbrant, Lars Edenbrant. Department of cardiology, Lund, Sweden, Department of Clinical Physiology, Lund, Sweden
Journal: Journal of the American College of Cardiology (2001)
Radiology posters 321-325
Authors: S Parry, J Barton, M Welfare, I Mohammed, L Cherkas, S Riley, T Spector, N Trudgill, S Lal, J Mclaughlin, G Giampaolo, G Dockray, A Varro, D Thompson, J Jones, D Kendall, P Millns, C Hawkey, S Dunlop, D Jenkins, R Spiller, L Gregory, L Yaguez, S Coen, E Amaro, S Smale, A Hobson, S Williams, Q Aziz, V Chudleigh, E Brennan, S Tarry, S Myers, S Lewis, G Smith, K Palmer
Journal: Gut (2002)

Introduction: Previous studies, many uncontrolled, suggest 4 to 32% of people develop irritable bowel syndrome (IBS) after ID.Little information is available on the development of other FGIDs after ID.Aim: To determine if patients with stool culture confirmed bacterial diarrhoea were more likely to develop gut symptoms consistent with a diagnosis of IBS, functional dyspepsia or functional diarrhoea at 3 and 6 month follow up compared with community controls.Methods: A prospective community-based case-control study over one year.Subjects with stool positive bacterial infectious diarrhoea and control subjects from the same primary care practice were invited to participate.The presence or not of IBS, functional dyspepsia or functional diarrhoea was diagnosed at the start and at follow up using self-complete Rome II modular questionnaires.The diagnosis of a baseline FGID excluded subjects from continuing.There were 128 cases and 219 community controls eligible and who consented to participate.Results: At follow up there was a higher incidence of FGIDs in the cases compared with controls, mainly due to a higher incidence of IBS (see table ).There was no difference in the incidence of functional dyspepsia between cases and controls.Conclusions: IBS and functional diarrhoea is diagnosed more frequently in people at three and six-month follow up after an episode of stool positive bacterial diarrhoea compared with community controls despite careful exclusion of people with pre-existing FGIDS and adds further support for the concept of post-infectious IBS.
SUBCONJUNCTIVAL INJECTIONS.
Authors: EDWARD J. BERNSTEIN
Journal: JAMA (1896)

Like all other remedial agents, subconjunctival injections must run the gauntlet of ill-considered judgments, both favorable and adverse, until its place shall have been firmly assigned. Few men, like Abadie, Darier, Deutschmann, Gepner, Schmidt-Rimpler, Pflueger and Zossenheim have yet had sufficient personal experience to entitle them to give conclusive verdicts. In the main, these men assert, we have in this method a means at our hand, swift, sure and intense, which under proper precautions and indications should stand us in good stead, whether employed alone or in conjunction with general treatment. That it is a panacea or infallible, not even an enthusiast will contend. Much adverse criticism comes from those who declare that we have no precise indication for its employment. Certainly we must,<i>in part</i>, admit this contention, but should one expect a hard and fast demarcation in a method so novel? Even Darier, who has been working in
Temporal effects on arterial repair of a sustained release formulation of sirolimus eluting from a stent Andrew J. Carter, Gregory Kopia, Lynn R. Bailey, Ronald Kolata, Julianne Meiester, Takeshi Suzuki, Gerard Llanos, Pallassana Narayan, George Papandreou, Robert Falotico, Fermin Tio. Stanford University Medical Center, Stanford, CA, University Texas San Antonio, San Antonio, TX
Journal: Journal of the American College of Cardiology (2001)
Quality of Life
Authors: George G. Rhoads
Journal: JAMA (1996)

It is obvious that quality of life is of central importance to patients, but few studies of the effect of medical interventions on quality of life appeared until the 1960s. After a slow start in that decade, the number of articles in the field has increased exponentially. In 1993 more than 1200 new articles were published relating solely to quality of life and cancer. This growth is fueled by improvements in measurement instruments that make it possible to document quality-of-life differences and the increasing realization that quality of life does not always correlate well with length of life or disease-free survival. Indeed, many important interventions for patients with chronic diseases, such as low-vision programs and certain rehabilitation efforts, may primarily affect quality of life while having little effect on measurable physiologic parameters. This book comprises 127 short reviews (chapters) written by more than 200 authors, who approach this exploding field
Homologous recombination repair pathway alterations and their relationship to homologous recombination deficiency in advanced pancreatic cancer patients.
Authors: Hitendra Patel, Alex Barrett, Elizabeth Mauer, Shumei Kato, Benjamin D. Leibowitz, Aatur D. Singhi, Milind M. Javle, Andrew M. Lowy
Journal: Journal of Clinical Oncology (2022)

609 Background: Homologous recombination repair (HRR) is critical for limiting DNA damage arising from double strand breaks. Disrupting HRR has emerged as a therapeutic strategy in pancreatic cancer given the development of PARP inhibitors that can specifically target tumors with homologous recombination deficiency (HRD). While HRD is strongly associated with loss-of-function mutations in BRCA1/2, a broad range of pathogenic alterations have been identified in other HRR genes. Identification of pathogenic alterations that predict response to PARP inhibition remains a critical knowledge gap in the field. Methods: We retrospectively analyzed de-identified records from 895 patients with advanced pancreatic cancer that underwent next generation sequencing (NGS) with the Tempus|xT assay (DNA-seq of 648 genes at 500x coverage, matched normal, full transcriptome RNA-seq). HRD-positivity and genome-wide loss of heterozygosity (LOH) were compared across groups, which were defined based on alterations to BRCA1/2 or other HRR pathway genes. Results: We identified 293/895 (33%) pancreatic cancer patients to be HRD-positive. Among HRD positive patients, 23/895 (2.6%) tumors harbored two alterations in BRCA1/2 (BRCA++), 179/895 (20%) harbored a single alteration in BRCA1/2 (BRCA+), 25/895 (2.8%) harbored two alterations in at least one other non-BRCA HRR gene (other HRR++), 367/895 (41%) harbored a single alteration in one other HRR gene (other HRR+), and 143/895 (16%) had pathogenic alterations in neither BRCA1/2 nor other HRR genes. In terms of HRD status, 23/23 (100%) of BRCA++ cases, 179/337 (53%) of BRCA+ cases, 4/25 (16%) of other HRR++ cases, and 87/367 (24%) of other HRR+ cases were HRD-positive. We observed no cases that were HRD-positive without an alteration in either BRCA1/2 or other HRR gene. Within the other HRR+ group, we found that single alterations in CHEK1/2, FANCA/L, MRE11, PALB2, and RAD51B were all significantly associated with HRD-positivity whereas CDK12, for instance, was not (Table). Conclusions: Comprehensive genomic profiling demonstrates that approximately 1 in 4 patients without BRCA alterations may potentially benefit from PARP inhibition due to alterations in other HRR genes. Future studies may examine the role of PARP inhibition in this population of HRR+ pancreatic cancer patients.[Table: see text]
Kenneth Roberts (1885-1957)
Authors: H. H. Hssey
Journal: JAMA (1971)

Readers of Kenneth Roberts' novels will surely agree with his good friend, Ben Ames Williams, who regarded him as the foremost authority on the first half-century of American history. His earlier work as a reporter and a writer of feature articles for the<i>Saturday Evening Post</i>may account in part for the fact that he was scrupulous and persevering in the research performed in preparation of his historical novels. Roberts seems to have had more than a passing interest in the medical profession.<i>Rabble in Arms</i>, first published in 1933, has as one of the principal characters, Doc Means, who was not a physician at all. Nevertheless, he is pictured as a self-taught, skilled healer of sprains by manipulation and wise in treating the sick. As an example of his art, Doc, having inoculated some young men with smallpox virus, travels with them through the wilderness to serve as scouts
Direct Current Cardioversion
Authors: James A. Reiffel
Journal: JAMA (1978)

Creatine kinase (CK), lactic dehydrogenase (LDH), and more recently their isoenzyme determinations (CK-MB and LDH<sub>1</sub>) have been useful adjuncts in verification of myocardial injury. To determine whether DC cardioversion affects these serum enzyme levels, we recorded total CK, total LDH, CK-MB, and LDH<sub>1</sub>levels serially during 24 hours following elective DC cardioversion in 18 patients without cardiac ischemia. New postcardioversion elevations in total CK and total LDH levels were small and occasional: CK (one of 18 patients), LDH (four of 18 patients). Elevations of CK-MB or LDH<sub>1</sub>following cardioversion did not develop in any of the patients. Therefore, new CK-MB or LDH<sub>1</sub>elevations associated with arrhythmias must result from myocardial damage to DC cardioversion. (<i>JAMA</i>239:122-124, 1978)
In Brief
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TCT-44 Comparative effectiveness and safety of five leading new-generation TAVI devices: 12-month results from the RISPEVA Study
Authors: Arturo Giordano, Giuseppe Biondi-Zoccai, Nicola Corcione, Paolo Ferraro, Francesco Bedogni, Luca Testa, Gennaro Sardella, Massimo Mancone, Fabrizio Tomai, Giovanni De Persio, Alessandro Iadanza, Carlo Pierli, Giacomo Frati
Journal: Journal of the American College of Cardiology (2018)
New insights into the interplay between long non‐coding RNAs and RNA‐binding proteins in cancer
Authors: Zi‐Ting Yao, Yan‐Ming Yang, Miao‐Miao Sun, Yan He, Long Liao, Kui‐Sheng Chen, Bin Li
Journal: Cancer Communications (2022)

Abstract With the development of proteomics and epigenetics, a large number of RNA‐binding proteins (RBPs) have been discovered in recent years, and the interaction between long non‐coding RNAs (lncRNAs) and RBPs has also received increasing attention. It is extremely important to conduct in‐depth research on the lncRNA‐RBP interaction network, especially in the context of its role in the occurrence and development of cancer. Increasing evidence has demonstrated that lncRNA‐RBP interactions play a vital role in cancer progression; therefore, targeting these interactions could provide new insights for cancer drug discovery. In this review, we discussed how lncRNAs can interact with RBPs to regulate their localization, modification, stability, and activity and discussed the effects of RBPs on the stability, transport, transcription, and localization of lncRNAs. Moreover, we explored the regulation and influence of these interactions on lncRNAs, RBPs, and downstream pathways that are related to cancer development, such as N6‐methyladenosine (m6A) modification of lncRNAs. In addition, we discussed how the lncRNA‐RBP interaction network regulates cancer cell phenotypes, such as proliferation, apoptosis, metastasis, drug resistance, immunity, tumor environment, and metabolism. Furthermore, we summarized the therapeutic strategies that target the lncRNA‐RBP interaction network. Although these treatments are still in the experimental stage and various theories and processes are still being studied, we believe that these strategies may provide new ideas for cancer treatment.
Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance
Authors: Sinem Karaman, Satu Paavonsalo, Krista Heinolainen, Madeleine H. Lackman, Amanda Ranta, Karthik A. Hemanthakumar, Yoshiaki Kubota, Kari Alitalo
Journal: The Journal of Experimental Medicine (2022)

Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are quintessential for the development and maintenance of blood and lymphatic vessels. However, genetic interactions between the VEGFRs are poorly understood. VEGFR2 is the dominant receptor that is required for the growth and survival of the endothelium, whereas deletion of VEGFR1 or VEGFR3 was reported to induce vasculature overgrowth. Here we show that vascular regression induced by VEGFR2 deletion in postnatal and adult mice is aggravated by additional deletion of VEGFR1 or VEGFR3 in the intestine, kidney, and pancreas, but not in the liver or kidney glomeruli. In the adult mice, hepatic and intestinal vessels regressed within a few days after gene deletion, whereas vessels in skin and retina remained stable for at least four weeks. Our results show changes in endothelial transcriptomes and organ-specific vessel maintenance mechanisms that are dependent on VEGFR signaling pathways and reveal previously unknown functions of VEGFR1 and VEGFR3 in endothelial cells.
Vitiligo
Authors: Tessa M. LeWitt, Roopal V. Kundu
Journal: JAMA Dermatology (2021)

PAGE VitiligoVitiligo is a condition in which the skin loses its color or pigmentation and becomes pale or white.Vitiligo can develop at any time, but usually appears before age 30 years.It affects men and women equally.Vitiligo occurs in people of all socioeconomic backgrounds, races, and ethnicities, but is more noticeable in people with skin of color.Vitiligo is not contagious or life threatening, but it can be life altering, leading to increased psychological stress or low self-esteem. Causes