tbuckley/cabot-search huggingface dataset:
Intradialytic Yoga-Based Breathing and Relaxation to Improve Anxiety, Depression, and Quality of Life: A Pilot Feasibility Study
Authors: Fran Conway, Martha N. Desta, Young sun Jung, Daniel M. Levine, Andrew Bohmart
Journal: Journal of the American Society of Nephrology (2021)

Background: In-center hemodialysis patients have high rates of depression and anxiety. Pharmacologic interventions to ameliorate psychological burdens have proven to be limited in efficacy. Alternative therapies are increasingly used for those with chronic disease. A small number of studies have looked at the impact of meditation and yoga to improve symptoms of anxiety and depression and to promote a better quality of life. The aim of this study was to test the feasibility of implementing a chairside intradialytic yogabased breathing and relaxation technique. A secondary goal was assessing the efficacy of such an intervention. Methods: Eligible subjects were patients with a below average score on the Mental Component Summary (MCS) of a previously completed Kidney Disease Quality of Life (KDQOL-36) survey. Following consent, each subject was provided with an MP3 player, pre-loaded with a 12-minute recording of a specific yogic breathing and relaxation exercise, the Three-Part Breath. The intervention consisted of listening to the recording at each dialysis treatment over a 12-treatment period. Subjects completed a KDQOL-36 survey both at the start and the end of the study. A Likert scale to measure anxiety was completed at each dialysis treatment both pre-and post-intervention. Results: 11 subjects were enrolled over a 10-month period in 2020;10 completed the study. As measured by the Likert scale, anxiety was significantly reduced after listening to the recording. Notably, there was a larger reduction in anxiety on a per treatment basis in the period after the start of the Covid-19 pandemic compared to the pre-pandemic period. Over the study period, there was a significant improvement in the scores of the Effects of Kidney Disease on Quality of Life component of the KDQOL-36, and a trend toward significant improvement in the Mental Component Summary scores. Conclusions: A chairside intradialytic breathing and relaxation program can be integrated into a dialysis treatment session. The study demonstrates an improvement in scores related to anxiety, depression, and measures of quality of life. Larger and randomized trials using this intervention are needed to better understand its benefits and adverse effects, as well as the obstacles to large scale implementation.
Self-anti-angiogenesis nanoparticles enhance anti-metastatic-tumor efficacy of chemotherapeutics
Authors: Jiamao Luo, Xinxian Zhong, Yingming Peng, Chenyuan Hao, Xiaomei Liang, Yulu Yang, Xiubo Shi, Xuncai Chen, Xiao Yi, Xiaoxuan Li, Jianhua Wu, Jinheng Li, Qian Xiao, Chentian Wu, Ruojing Lu, Yao Pan, Xuejiao Wang, Jun-Bing Fan, Yifeng Wang, Ying Wang
Journal: Bioactive Materials (2021)

Beyond traditional endothelium-dependent vessel (EDV), vascular mimicry (VM) is another critical tumor angiogenesis that further forms in many malignant metastatic tumors. However, the existing anti-angiogenesis combined chemotherapeutics strategies are only efficient for the treatment of EDV-based subcutaneous tumors, but remain a great challenge for the treatment of in situ malignant metastatic tumor associated with EDV and VM. Here, we demonstrate a self-assembled nanoparticle (VE-DDP-Pro) featuring self-anti-EDV and -VM capacity enables to significantly enhance the treatment efficacy of cisplatin (DDP) against the growth and metastasis of ovarian cancer. The VE-DDP-Pro is constructed by patching DDP loaded cRGD-folate-heparin nanoparticles (VE) onto the surface of protamine (Pro) nanoparticle. We demonstrated the self-anti-angiogenesis capacity of VE-DDP-Pro was attributed to VE, which could significantly inhibit the formation of EDV and VM by regulating signaling pathway of MMP-2/VEGF, AKT/mTOR/MMP-2/Laminin and AKT/mTOR/EMT, facilitating chemotherapeutics to effectively suppress the development and metastasis of ovarian cancer. Thus, combing with the chemotherapeutics effectiveness of DDP, the VE-DDP-Pro can significantly enhance treatment efficacy and prolong median survival of mice with metastatic ovarian cancer. We believe our self-assembled nanoparticles integrating the
GP numbers pledge: health secretary admits government won’t deliver
Authors: Abi Rimmer, Elisabeth Mahase
Journal: BMJ (2021)

The government is not on track to hit its target of 6000 more GPs by 2024-25, health secretary Sajid Javid has admitted.

Speaking to the House of Commons Health and Social Care Committee on 2 November Javid said, “I’m looking at what more we can do. But I’m not going to pretend we’re on track when we’re not.”

He went on to highlight the “unimaginable pressures” that general practice has been facing. “We’ve got to look at other ways we can support GPs, it’s got to be about investment …
TCT-95 TEE- and Fluoroscopy-Guided WATCHMAN Implantation Without Administration of Iodinated Contrast Material
Authors: Shawn Gogia, Omar Khalique, Nadira Hamid, Jessica Forman, Vivian Ng, Rebecca Hahn, Martin Leon, Robert Sommer, Torsten Vahl
Journal: Journal of the American College of Cardiology (2021)
Subcutaneous Daratumumab with Bortezomib, Cyclophosphamide, and Dexamethasone in Patients with Newly Diagnosed Light Chain (AL) Amyloidosis: 18-Month Analysis of the Phase 3 ANDROMEDA Study
Authors: Raymond Comenzo, Giovanni Palladini, Efstathios Kastritis, Monique C. Minnema, Ashutosh D. Wechalekar, Arnaud Jaccard, Angela Dispenzieri, Hans C. Lee, Vaishali Sanchorawala, Simon D. Gibbs, Peter Mollee, Chris P. Venner, Jin Lu, Stefan Schönland, Moshe Gatt, Kenshi Suzuki, Kihyun Kim, M. Teresa Cibeira, Meral Beksac, Edward Libby, Jason Valent, Vania Hungria, Sandy W. Wong, Michael Rosenzweig, Naresh Bumma, NamPhuong Tran, Xiang Qin, Samer Khaled, Jessica Vermeulen, Giampaolo Merlini
Journal: Blood (2021)
Utilizing preclinical models to develop targeted therapies for rare central nervous system cancers
Authors: Aleena K S Arakaki, Frank Szulzewsky, Mark R Gilbert, Taranjit S Gujral, Eric C Holland
Journal: Neuro-Oncology (2021)

Patients with rare central nervous system (CNS) tumors typically have a poor prognosis and limited therapeutic options. Historically, these cancers have been difficult to study due to small number of patients. Recent technological advances have identified molecular drivers of some of these rare cancers which we can now use to generate representative preclinical models of these diseases. In this review, we outline the advantages and disadvantages of different models, emphasizing the utility of various in vitro and ex vivo models for target discovery and mechanistic inquiry and multiple in vivo models for therapeutic validation. We also highlight recent literature on preclinical model generation and screening approaches for ependymomas, histone mutated high-grade gliomas, and atypical teratoid rhabdoid tumors, all of which are rare CNS cancers that have recently established genetic or epigenetic drivers. These preclinical models are critical to advancing targeted therapeutics for these rare CNS cancers that currently rely on conventional treatments.
Treatment of recurrent mucosal melanoma of the oral cavity with topical imiquimod and pembrolizumab achieves complete histopathologic remission
Authors: Tejus Satish, Shaheer Khan, Matt Levin, Richard Carvajal, Angela J Yoon
Journal: Journal for ImmunoTherapy of Cancer (2021)

Mucosal melanomas constitute a subtype of melanoma with less effective treatments than cutaneous melanomas. We present a case of oral mucosal melanoma that recurred despite multiple resections and adjuvant temozolomide. Treatment with topical imiquimod combined with pembrolizumab achieved remission. A 56-year-old woman presented with a pigmented mass on her left anterior hard palate. Biopsy revealed malignant melanoma. The patient had resection with neck dissection with 3 months of adjuvant temozolomide due to positive margins. Malignant melanoma involving the hard palate recurred 1 year later requiring additional resection. Two years later, two additional pigmented lesions were found; further resections were deferred due to expected morbidity. Following 6 weeks of topical imiquimod treatment, the lesions shrunk significantly. Adjuvant pembrolizumab was added and complete histopathologic remission was observed in 6 months. The patient remained in remission for 4 years before new melanoma in situ was diagnosed, requiring five additional months of imiquimod. As of April 2021, there is no clinical evidence of melanoma. There are limited reports of oral melanoma treated with topical imiquimod. Here, imiquimod administered in combination with pembrolizumab achieved complete pathologic response.
Are vaccine passports and covid passes a valid alternative to lockdown?
Authors: Daniel Sleat, Kirsty Innes, Imogen Parker
Journal: BMJ (2021)

As countries reopen while the pandemic continues, "passports" indicating a person's covid or vaccination status are the only obvious way to leave lockdowns behind, say <b>Kirsty Innes</b> and <b>Daniel Sleat</b>. But the risks are big—and if we start down that road we may struggle to go back, argues <b>Imogen Parker</b>
NK cell receptor and ligand composition influences the clearance of SARS-CoV-2
Authors: Wan-Chen Hsieh, En-Yu Lai, Yu-Ting Liu, Yi-Fu Wang, Yi-Shiuan Tzeng, Lu Cui, Yun-Ju Lai, Hsiang-Chi Huang, Jia-Hsin Huang, Hung-Chih Ni, Dong-Yan Tsai, Jian-Jong Liang, Chun-Che Liao, Ya-Ting Lu, Laurence Jiang, Ming-Tsan Liu, Jann-Tay Wang, Sui-Yuan Chang, Chung-Yu Chen, Hsing-Chen Tsai, Yao-Ming Chang, Gerlinde Wernig, Chia-Wei Li, Kuo-I Lin, Yi-Ling Lin, Huai-Kuang Tsai, Yen-Tsung Huang, Shih-Yu Chen
Journal: Journal of Clinical Investigation (2021)

To explore how the immune system controls clearance of SARS-CoV-2, we used a single-cell, mass cytometry–based proteomics platform to profile the immune systems of 21 patients who had recovered from SARS-CoV-2 infection without need for admission to an intensive care unit or for mechanical ventilation. We focused on receptors involved in interactions between immune cells and virus-infected cells. We found that the diversity of receptor repertoires on natural killer (NK) cells was negatively correlated with the viral clearance rate. In addition, NK subsets expressing the receptor DNAM1 were increased in patients who more rapidly recovered from infection. Ex vivo functional studies revealed that NK subpopulations with high DNAM1 expression had cytolytic activities in response to target cell stimulation. We also found that SARS-CoV-2 infection induced the expression of CD155 and nectin-4, ligands of DNAM1 and its paired coinhibitory receptor TIGIT, which counterbalanced the cytolytic activities of NK cells. Collectively, our results link the cytolytic immune responses of NK cells to the clearance of SARS-CoV-2 and show that the DNAM1 pathway modulates host-pathogen interactions during SARS-CoV-2 infection.
Abstract 12181: Single-cell RNA-seq and Patient-specific IPSCs Reveal Endocardial and Endothelial Abnormalities in Hypoplastic Left Heart Syndrome
Authors: Yifei Miao, Lei Tian, Francisco X Galdos, Sharon Paige, Marcy Martin, Ning Ma, Joseph C Wu, Timothy J Nelson, Sean M Wu, Mingxia Gu
Journal: Circulation (2019)

Hypoplastic left heart syndrome (HLHS) is a fatal single ventricle malformation which results in severe underdevelopment of left ventricle, mitral valve, aortic valve, and ascending aorta. Previous...
TCT-17 Jetstream Atherectomy Followed by Paclitaxel-Coated Balloons Versus Balloon Angioplasty Followed by Paclitaxel-Coated Balloons: Twelve-Month Results of the Prospective Randomized JET-RANGER Study
Authors: Nicolas Shammas, Bhaskar Purushottam, W John Shammas, Lori Christensen, Gail Shammas, Desyree Weakley, Sue Jones-Miller
Journal: Journal of the American College of Cardiology (2021)
Reply to Sanjay B. Kulkarni, Pankaj M. Joshi, Marco Bandini, et al.’s Letter to the Editor re: Sanad Saad, Nadir I. Osman, Christopher R. Chapple. Female Urethra: Is Ventral the True Dorsal? Eur Urol 2020;78:e218–9
Authors: Sanad Saad, Nadir I Osman, Christopher R Chapple
Journal: European Urology (2021)
TCT-268 Nicardipine to Avoid Spasm in Trans Radial Percutaneous Coronary Intervention: Results of an Ongoing Double Blinded Multicenter Randomized Trial
Authors: Nidhal Bouchahda, Aymen Ben Abdesselem, Najeh Ben Halima, Hichem Denguir, Mejdi Ben Massaoud, Wassim Saoudi, Mohamed Mehdi Boussaada, Mahdhaoui Abdallah, Habib Gamra
Journal: Journal of the American College of Cardiology (2021)
TCT-221 Serial Fractional Flow Reserve, Coronary Flow Reserve, and Index of Microcirculatory Resistance After Percutaneous Coronary Intervention in Patients Treated for Stable Angina Pectoris Assessed With Positron Emission Tomography
Authors: Kristoffer Bendix, Anders Junker, Karsten Veien, Lisette Okkels Jensen
Journal: Journal of the American College of Cardiology (2021)
In Vivo Dynamics of the Latent Reservoir for HIV-1: New Insights and Implications for Cure
Authors: Janet D. Siliciano, Robert F. Siliciano
Journal: Annual Review of Pathology Mechanisms of Disease (2021)

Although antiretroviral therapy (ART) can reduce viremia to below the limit of detection and allow persons living with HIV-1 (PLWH) to lead relatively normal lives, viremia rebounds when treatment is interrupted. Rebound reflects viral persistence in a stable latent reservoir in resting CD4+ T cells. This reservoir is now recognized as the major barrier to cure and is the focus of intense international research efforts. Strategies to cure HIV-1 infection include interventions to eliminate this reservoir, to prevent viral rebound from the reservoir, or to enhance immune responses such that viral replication is effectively controlled. Here we consider recent developments in understanding the composition of the reservoir and how it can be measured in clinical studies. We also discuss exciting new insights into the in vivo dynamics of the reservoir and the reasons for its remarkable stability. Finally we discuss recent discoveries on the complex processes that govern viral rebound.
Keeping the Vascular Access Alive During the COVID-19 Pandemic
Authors: Min S. Cho, Cesar F. Hernandez-Arroyo, Muhammad Sohaib Karim, Micah R. Chan, Brad C. Astor, Ali I. Gardezi
Journal: Journal of the American Society of Nephrology (2021)

Cho, Min S.; Hernandez-Arroyo, Cesar F.; Karim, Muhammad Sohaib; Chan, Micah R.; Astor, Brad C.; Gardezi, Ali I. Author Information
The antiviral and immunomodulatory activities of propolis: An update and future perspectives for respiratory diseases
Authors: Andrea Magnavacca, Enrico Sangiovanni, Giorgio Racagni, Mario Dell'Agli
Journal: Medicinal Research Reviews (2021)

Propolis is a complex natural product that possesses antioxidant, anti-inflammatory, immunomodulatory, antibacterial, and antiviral properties mainly attributed to the high content in flavonoids, phenolic acids, and their derivatives. The chemical composition of propolis is multifarious, as it depends on the botanical sources from which honeybees collect resins and exudates. Nevertheless, despite this variability propolis may have a general pharmacological value, and this review systematically compiles, for the first time, the existing preclinical and clinical evidence of propolis activities as an antiviral and immunomodulatory agent, focusing on the possible application in respiratory diseases. In vitro and in vivo assays have demonstrated propolis broad-spectrum effects on viral infectivity and replication, as well as the modulatory actions on cytokine production and immune cell activation as part of both innate and adaptive immune responses. Clinical trials confirmed propolis undeniable potential as an effective therapeutic agent; however, the lack of rigorous randomized clinical trials in the context of respiratory diseases is tangible. Since propolis is available as a dietary supplement, possible use for the prevention of respiratory diseases and their deleterious inflammatory drawbacks on the respiratory tract in humans is considered and discussed. This review opens up new perspectives on the clinical investigation of neglected propolis biological properties which, now more than ever, are particularly relevant with respect to the recent outbreaks of pandemic respiratory infections.
Nephrology Education Needs Assessment: Five Years and a Pandemic Later
Authors: Benjamin S. Ko, Rob Rope, Kurtis Pivert, Anna M. Burgner, Joshua S. Waitzman, Susan M. Halbach, Suzanne Boyle, Lili Chan, Hitesh H. Shah, Stephen M. Sozio
Journal: Journal of the American Society of Nephrology (2021)

Background: We sought to identify how educational tools utilized in nephrology training had evolved in the past 5 years and through the COVID-19 pandemic. Methods: Questions about educational tools were distributed as part of ASN's annual nephrology fellow survey to 920 current adult/pediatric fellows. Results: 511 fellows participated in 2021 (56% response rate), compared with 377 fellows in 2016 (31% response rate). Fellows indicated that UpToDate was still the most used (82%) and most effective educational tool (66% rated it Very Effective);however, ASN KSAP increased in popularity (27% in 2016, 58% 2021) and was also highly rated (65% Very Effective). Use of online resource and social media increased, including both new opportunities and prior available ones such as NephJC (7% to 32%, with 46% rated Very Effective) (Figure 1). A majority of fellows (84%) rated their education as good or excellent in 2021, a percentage similar to 2016 (81%). Conclusions: Our follow-up assessment of nephrology fellows' educational tools found an increase in the adoption of online resources with similar effectiveness ratings as traditional resources. (Figure Presented).
Combined duodenal stenting and endoscopic ultrasound-guided hepaticogastrostomy using forward-viewing echoendoscope: a one-scope technique
Authors: Moaz Elshair, Kazuo Hara, Shin Haba, Takamichi Kuwahara, Nozomi Okuno, Asmaa Bakr, Mohamed Z. Abu-Amer
Journal: Endoscopy (2021)

Gastric cancer is the second leading cause of cancer mortality all over the world. Although early detection has increased the curative resection, many cases still present in an advanced stage with gastric outlet obstruction and lymph node metastasis [1] [2]. Here, we report a novel technique for palliative management of pyloric obstruction and obstructive jaundice in the same session using a forward-viewing echoendoscope.
TCT-503 Survival of Patients With Chronic Coronary Total Occlusions With Normal, Midrange, and Low Ejection Fractions: The Role of Percutaneous Revascularization
Authors: None Dobrin Vassilev, Niya Mileva, Panayot Panayotov, Katerina Sokolova, Pavel Nikolov, Vladimir Naunov, Carlos Collet, Kiril Karamfiloff, Gianluca Rigatelli, Robert Gil
Journal: Journal of the American College of Cardiology (2021)
Kidney Disease in the Aftermath of COVID-19 Infection
Authors: Megan K. Gallagher, Demetrio Sharp Dimitri, Diping Wang, Sharmeela Saha
Journal: Journal of the American Society of Nephrology (2021)

Gallagher, Megan K.; Dimitri, Demetrio Sharp; Wang, Diping; Saha, Sharmeela Author Information
Contact and SARS-CoV-2 Infections Among College Football Athletes in the Southeastern Conference During the COVID-19 Pandemic
Authors: Benika C. Dixon, Rebecca S. B. Fischer, Hongwei Zhao, Catherine S. O’Neal, James R. Clugston, Shawn G. Gibbs
Journal: JAMA Network Open (2021)

SARS-CoV-2 Infections in Close Contacts of Positive Cases in the Olympic and Paralympic Village at the 2021 Tokyo Olympic and Paralympic Games
Outcomes of COVID-19 Infection in Dialysis vs. Kidney Transplant Patients: A Nationwide Cohort Study from Qatar
Authors: Tarek A. Ghonimi, Abdullah I. Hamad, Mohamad M. Alkadi, Essa Abuhelaiqa, Rania A. Ibrahim, Shajahan J. Kadukkamoottil, Musab Elgaali, Muftah Othman, Hany E. Ismail, Karima Boubaker, Hassan A. Al-Malki
Journal: Journal of the American Society of Nephrology (2021)

Ghonimi, Tarek A.; Hamad, Abdullah I.; Alkadi, Mohamad M.; Abuhelaiqa, Essa; Ibrahim, Rania A.; Kadukkamoottil, Shajahan J.; Elgaali, Musab; Othman, Muftah; Ismail, Hany E.; Boubaker, Karima; Al-Malki, Hassan A. Author Information
TCT-138 Right Ventricular Remodeling and Clinical Outcomes Following Transcatheter Tricuspid Valve Intervention
Authors: Lyle Dershowitz, Matthew Lawlor, Nadira Hamid, Polydoros Kampaktsis, Yuming Ning, Victoria Wang, Deniz Akkoc, Elizabeth Placheril, Torsten Vahl, Tamim Nazif, Omar Khalique, Vivian Ng, Michael Brener, Daniel Burkhoff, Marc Dickstein, Paul Kurlansky, Martin Leon, Rebecca Hahn, Susheel Kodali, Isaac George
Journal: Journal of the American College of Cardiology (2021)
How bad is the UK’s covid situation?
Authors: Chris Stokel-Walker
Journal: BMJ (2021)

How bad is the UK's covid situation?case rates and hospital pressures going into winter are provoking much debate.Chris Stokel-Walker asks how poorly the UK is doing in comparison with other countries Chris Stokel-Walker freelance journalistThe UK seems to be in an invidious position in the pandemic: on 24 October there were 46 358 new cases and 136 deaths within 28 days of a positive covid test (daily averages for the previous seven days). 1 Social media are abuzz with charts comparing the UK's high rates of cases and deaths unfavourably with its continental counterparts.Italy's prime minister, Mario Draghi, cited the UK model of rapid vaccine rollout followed by "abandoning all caution" as an example not to follow.The situation seems bad.But is it?
High-Throughput immunogenetics for precision medicine in cancer
Authors: Andreas Agathangelidis, Elisavet Vlachonikola, Frederic Davi, Anton W. Langerak, Anastasia Chatzidimitriou
Journal: Seminars in Cancer Biology (2021)

Cancer is characterized by an extremely complex biological background, which hinders personalized therapeutic interventions. Precision medicine promises to overcome this obstacle through integrating information from different 'subsystems', including the host, the external environment, the tumor itself and the tumor micro-environment. Immunogenetics is an essential tool that allows dissecting both lymphoid cancer ontogeny at both a cell-intrinsic and a cell-extrinsic level, i.e. through characterizing micro-environmental interactions, with a view to precision medicine. This is particularly thanks to the introduction of powerful, high-throughput approaches i.e. next generation sequencing, which allow the comprehensive characterization of immune repertoires. Indeed, NGS immunogenetic analysis (Immune-seq) has emerged as key to both understanding cancer pathogenesis and improving the accuracy of clinical decision making in oncology. Immune-seq has applications in lymphoid malignancies, assisting in the diagnosis e.g. through differentiating from reactive conditions, as well as in disease monitoring through accurate assessment of minimal residual disease. Moreover, Immune-seq facilitates the study of T cell receptor clonal dynamics in critical clinical contexts, including transplantation as well as innovative immunotherapy for solid cancers. The clinical utility of Immune-seq represents the focus of the present contribution, where we highlight what can be achieved but also what must be addressed in order to maximally realize the promise of Immune-seq in precision medicine in cancer.
Medical journal requirements for clinical trial data sharing: Ripe for improvement
Authors: Florian Naudet, Maximilian Siebert, Claude Pellen, Jeanne Gaba, Cathrine Axfors, Ioana Cristea, Valentin Danchev, Ulrich Mansmann, Christian Ohmann, Joshua D. Wallach, David Moher, John P. A. Ioannidis
Journal: PLoS Medicine (2021)

Florian Naudet and co-authors discuss strengthening requirements for sharing clinical trial data.
TCT-92 Comparison of Procedural, Safety, and Efficacy Outcomes of Watchman FLX Versus Watchman 2.5
Authors: Sri Mandava, Benita Tjoe, Samantha Yim, Michael Shenoda, Colin Shafer, David Lerner, Taylor Holve, Brett Gidney, Joseph Aragon
Journal: Journal of the American College of Cardiology (2021)