tbuckley/cabot-search huggingface dataset:
Non-endemic Burkitt's lymphoma.
Authors: N L Snyderman, M Z Effron, C H Srodes, J T Johnson
Journal: BMJ (1978)

the procedure alter decision-making about the next step in the management sequence for the individual patient, and, secondly, how does it help in the discussions between doctor and patient over the likely cause of the problem?For needle aspiration cytology we do not have the requisite information, though again some clinicians would claim that as their experience grows subtle changes are manifest in clinical practice.In this, as in so many other diagnostic topics, a prospective survey which addresses the final problem of utility is needed rather than repeated publications which attest to the technical success, sensitivity, and discrimination of the method.
Ultrasonic assessment of the St. Jude prosthetic valve: M mode, two-dimensional, and Doppler echocardiography.
Authors: I RWeinstein, J PMarbarger, J EPérez
Journal: Circulation (1983)

To determine whether the flow characteristics of aortic and mitral St. Jude Medical valves could be defined noninvasively, we analyzed Doppler transprosthetic flow velocity spectra in 23 relatively asymptomatic patients. Results were interpreted in the framework of M mode and two-dimensional echocardiographic data and were compared with Doppler transvalvular flow velocity spectra from native valves of healthy subjects. Although the morphologic characteristics of Doppler spectra were similar, peak and mean transprosthetic mitral flow velocities were higher than values obtained across native valves (1.38 +/- 0.3 m/sec and 0.73 +/- 0.1 m/sec vs 0.78 +/- 0.1 m/sec and 0.35 +/- 0.06 m/sec, respectively; p less than .001). However, calculated pressure half-times were not different (61.2 +/- 16.9 msec vs 57.2 +/- 13.2 msec; p greater than .05) and calculated transprosthetic mitral gradients were small (2.3 +/- 0.9 mm Hg). Similarly, the morphologic characteristics of aortic Doppler flow spectra in St. Jude and n...
Stent Retrievers for Treating Anterior Circulation Acute Ischemic Stroke—Reply
Authors: Lahoud Touma, Kristian B. Filion, Mark J. Eisenberg
Journal: JAMA Neurology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Calcium-activated chloride current in rabbit coronary artery myocytes.
Authors: F SLamb, K AVolk, E FShibata
Journal: Circulation Research (1994)

Whole-cell patch-clamp techniques were used to study enzymatically dispersed epicardial coronary artery smooth muscle cells. Depolarizing voltage pulses of 500-millisecond duration from -60 mV (118 mmol/L CsCl, 22 mmol/L tetraethylammonium chloride, and 5 mmol/L EGTA pipette solution) elicited inward L-type calcium currents (ICa). When EGTA was omitted from the pipette solution, an outward current was superimposed on the calcium current, and repolarizing voltage steps produced an inward tail current (IT). The amplitude of these inward currents was proportional to the ICa amplitude from -30 to +50 mV. The time course of decay of the current was well fit by a single exponential equation. The time constant (tau) of this equation did not change with the size of IT but was clearly voltage dependent (shorter at more negative potentials). Changing the chloride reversal potential from -1.3 to -39.7 mV by anion substitution using methanesulfonate as the chloride replacement in the pipette solution shifted the zero...
Benefit of exercise conditioning for patients with peripheral arterial disease.
Authors: W RHiatt, J GRegensteiner, M EHargarten, E EWolfel, E PBrass
Journal: Circulation (1990)

Patients with atherosclerotic peripheral arterial disease (PAD) of the lower extremities have impaired walking ability due to exercise-induced muscle ischemia and the resultant pain of intermittent claudication. To evaluate the benefit of exercise training as a treatment for patients with PAD, as well as possible mechanisms associated with improvement, we randomly assigned 19 men with disabling claudication to treated and control groups. Treatment consisted of supervised treadmill walking (1 hr/day, 3 days/wk, for 12 weeks) with progressive increases in speed and grade as tolerated. Graded treadmill testing was performed to maximal toleration of claudication pain on entry and after 12 weeks of training to define changes in peak exercise performance. After 12 weeks, treated subjects had increased their peak walking time 123%, peak oxygen consumption 30%, and pain-free walking time 165% (all p less than 0.05). Control subjects had no change in peak oxygen consumption, but after 12 weeks, peak walking time i...
Molecular cloning, expression, and chromosomal localization of two isoforms of the AE3 anion exchanger from human heart.
Authors: DYannoukakos, AStuart-Tilley, H AFernandez, PFey, GDuyk, S LAlper
Journal: Circulation Research (1994)

Cl-/HCO3- exchange contributes to regulation of pHi and [Cl-] in  muscle, with possible effects on excitability and contractility. We have isolated human heart cDNAs, which encode two isoforms of the anion exchanger AE3. These clones share long portions of common sequence but have different 5' ends encoding distinct amino-terminal amino acid sequences. The longer AE3 polypeptide of 1232 amino acids, bAE3, displays nearly 96% amino acid sequence identity to the rat and mouse AE3 brain isoforms. The shorter cAE3 polypeptide of 1034 amino acids in length corresponds to the rat AE3 cardiac isoform. The unique N-terminal 73 amino acids of the cAE3 sequence are less well conserved between rat and human. Northern blot analysis with isoform-specific probes revealed the presence of both cAE3 and bAE3 mRNAs in human heart tissue. Both AE3 protein isoforms were overexpressed in Chinese hamster ovary cells and detected by immunoblot with antipeptide antibodies. Immunoblot studies of human  membranes...
Dynamic stiffness measured in central segment of excised rabbit papillary muscles during barium contracture.
Authors: TShibata, W CHunter, AYang, KSagawa
Journal: Circulation Research (1987)

The dynamic mechanical behavior of excised rabbit papillary muscles that had been tonically activated by replacing bathing Ca2+ with Ba2+ was studied. Steady activation was used to visualize the dynamic behavior of cardiac myofilaments more clearly than is possible during twitches, which are complicated by the kinetics of excitation-contraction coupling. To avoid artifacts due to damaged ends of the muscle, the length of a central segment, which was defined by 2 tungsten pins inserted through the muscle, was measured. To test the mechanical behavior of the contractured muscles (at 24 degrees C), the central segment length was sinusoidally oscillated (amplitude 1%) at 15 different frequencies (0.05-30 Hz). The dynamic stiffness of the central segment was calculated from the ratio of force response amplitude to length perturbation amplitude. At low frequencies (below 0.4 Hz), stiffness was approximately constant and reflected the force-length relation. However, in a localized range near 1 Hz, there was a di...
Cost Comparisons Of Endoscopic And Surgical Resection Of T1 Rectal Cancer
Authors: V Arthursson, R Rosén, JM Norlin, K Gralén, E Toth, I Syk, H Thorlacius, CF Rönnow
Journal: Endoscopy (2021)

Aims The aim of this study was to compare costs of endoscopic and surgical resection and to investigate hypothetical cost scenarios for the treatment of T1 rectal cancer (RC).
Clinical characteristics associated with myocardial infarction, arrhythmias, and sudden death in patients with vasospastic angina.
Authors: MNakamura, ATakeshita, YNose
Journal: Circulation (1987)

A total of 349 patients with vasospastic angina were followed in eight centers in Japan for a period of 3.4 +/- 0.1 years (mean +/- SE). Ninety-eight percent of patients were treated with calcium blockers. Twenty-one episodes of myocardial infarction occurred in 18 patients (5%), including two fatal myocardial infarctions. The rate of myocardial infarction was higher (p less than .01) in patients with a fixed stenosis of 90% or greater than in patients with a fixed stenosis of less than 90% or normal coronary arteries. Myocardial infarctions occurred predominantly during hospital stays or at a time when the frequency of vasospastic angina increased. There were five sudden deaths (2%). Only one patient suffering sudden death had a fixed stenosis of 75% or greater. Serious arrhythmias were noted in 49 patients (14%). The risk of arrhythmias did not depend on the presence of a fixed stenosis of 75% or greater. These results suggest that cardiac events are rather infrequent in Japanese patients with vasospast...
Electrocardiographic quantitation of ventricular repolarization.
Authors: MMerri, JBenhorin, MAlberti, ELocati, A JMoss
Journal: Circulation (1989)

Quantification of the electrocardiographic ventricular repolarization involving the T-U wave complex is usually performed with reference to the axis of the T wave and the QT interval duration. A novel quantitative approach to improve the description of ventricular repolarization was applied to the digitized electrocardiograms of 423 normal subjects. Six electrocardiographic repolarization characteristics were identified: duration, rate, area, symmetry, late phenomena, and interlead heterogeneity. A computer algorithm was designed to automatically interpret the electrocardiographic repolarization segment and measure 11 variables that quantified these repolarization characteristics. The application of redundancy-reduction techniques selected a final set of seven variables that were used in the statistical analysis. The QT interval, which was included in the initial group of variables, was replaced by the time interval between S wave offset and T wave maximum. All selected electrocardiographic variables were...
Temporary inhibition of permanently implanted demand pacemakers.
Authors: PLatif, G AEwy
Journal: Circulation (1977)

Temporary inhibition of permanently implanted demand pacemakers has been previously described. Demand pacemakers may be inhibited by waving a magnet over the region of the pacemaker generator or by chest wall stimulation. The former may not inhibit most of the bipolar pacemakers, whereas the latter may be time consuming and may casue patient discomfort. Another method is described which utilized a commercially available Cordis Omnicor Programmer, Model 166-B, to temporarily inhibit bipolar and unipolar pacemakers. By placing the programmer over the skin where the pacemaker generator is implanted and/or over the area of the subcutaneous pervenous lead and activating the programmer multiple times at a rate faster then the pacing rate, the demand pacemakers are inhibited. After testing the efficacy in vitro, the method was successfully tried on 45 patients. Fifteen of these patients had unipolar pacemakers. Pacemakers marketed by Medtronic, Cordis, Starr-Edwards, C.P.I., and Arco were tested. Temporary inhib...
Left ventricular wall motion response to intravenous propranolol.
Authors: S JShubrooks, L MZir, R EDinsmore, J WHarthorne
Journal: Circulation (1975)

The effects of intravenous propranolol on left ventricular wall motion and hemodynamics were studied in 16 patients, 12 with significant coronary artery disease and four with chest pain but no coronary disease. Eight patients received 0.10 mg/kg and eight received 0.15 mg/kg of propranolol intravenously. All underwent atrial pacing at a constant rate. Left ventricular angiograms were performed before and 20 minutes after propranolol. At both doses, propranolol caused no significant change in left ventricular systolic or diastolic pressures, either before or immediately following ventriculography. Cardiac index fell significantly (3.4 plus or minus 0.2 [SEM] to 2.6 plus or minus 0.1 L/min/m-2) with the higher dose only. Of the ten patients with coronary artery disease and adequate ventriculograms, one patient had a normal left ventricle, two had regional hypokinesis, only three had areas of hypokinesis and akinesis, two had dyskinetic and akinetic areas, and two had areas of hypokinesis, akinesis and dyski...
Effect of acidosis on contraction of microvascular smooth muscle by alpha 1- and alpha 2-adrenoceptors. Implications for neural and metabolic regulation.
Authors: K MMcGillivray-Anderson, J EFaber
Journal: Circulation Research (1990)

Our previous studies have identified that adrenergic regulation of large arterioles and venules in skeletal muscle uses both postjunctional alpha 1- and alpha 2-adrenoceptors, whereas terminal arterioles appear to be subserved primarily by alpha 2-receptors. Adrenergic constriction of terminal arterioles is known to be particularly susceptible to inhibition by increased tissue metabolic rate. The purpose of this study was to examine the influence of tissue acidosis on alpha 1- and alpha 2-adrenoceptor constriction of skeletal muscle microvessels to determine if this differential receptor distribution might have significance in neural-metabolic interactions. Intravital microscopy of rat cremaster skeletal muscle was used to obtain concentration-response curves (diameter changes) of large distributing arterioles (mean diameter, 100 microns), small precapillary arterioles (20 microns), and capacitance venules (150 microns) for addition to the tissue bath of alpha-adrenergic agonists during normal pH (7.4) an...
Prognostic value of electrophysiology testing in asymptomatic patients with Wolff-Parkinson-White pattern.
Authors: J WLeitch, G JKlein, RYee, CMurdock
Journal: Circulation (1990)

The prognostic value of electrophysiology testing was studied in 75 asymptomatic patients with the Wolff-Parkinson-White electrocardiographic pattern. All patients underwent electrophysiology testing at entry to the study and were followed up annually for a total of 348 patient-years (median, 4.3 years). There were 44 male and 31 female patients, and age at enrollment ranged from 7 to 77 years (mean, 34 +/- 14 years). The median effective refractory period of the accessory pathway was 293 msec (interquartile range, 280-310 msec), and the median shortest RR interval between preexcited beats during atrial fibrillation (SRR) [corrected] was 274 msec (240-320 msec). Twenty-three patients had an SRR of 250 msec or less and eight patients had a median shortest SRR interval of 200 msec or less. Twelve patients had inducible sustained reciprocating tachycardia, 10 patients had inducible nonsustained reciprocating tachycardia, and 23 patients had inducible sustained atrial fibrillation. Twenty patients (27%) lacke...
In vivo induction of "focal" triggered ventricular arrhythmias and responses to overdrive pacing in the canine heart.
Authors: TFurukawa, SKimura, ACatstellanos, A LBassett, R JMyerburg
Journal: Circulation (1990)

Delayed afterdepolarizations and triggered activity were evoked in focal areas of myocardium in vivo by local exposure of endocardium to ouabain by means of a catheter electrode system capable of recording monophasic action potentials (MAPs) and delivering ouabain to the recording site. MAPs were recorded from the septum and the posterior wall of the left ventricle with silver-silver chloride electrode catheters. Ouabain (10(-5) M) was infused through the MAP recording catheter onto the endocardial surface of the septum. After infusion of 10 micrograms/kg ouabain, the amplitude of MAPs recorded from the septum (the site of ouabain infusion) decreased from 37.4 +/- 11.8 to 32.0 +/- 10.1 mV (p less than 0.01), MAP duration at 50% repolarization shortened from 160 +/- 29 to 148 +/- 34 msec (p less than 0.01), and MAP duration at 90% repolarization shortened from 198 +/- 38 to 189 +/- 46 msec (p less than 0.01). MAPs recorded from the posterior wall (the reference site) were unchanged. Delayed afterdepolariza...
Dynamic discharge characteristics of low pressure receptors in the rat.
Authors: SMifflin, DKunze
Journal: Circulation Research (1984)

An in vitro preparation was used to examine the discharge of low pressure receptors in response to a pulsatile pressure stimulus. Both slowly adapting and rapidly adapting receptors were examined. After an increase in the mean level and/or dP/dt of a pulsatile pressure input, the discharge of slowly adapting receptors reached a steady state level within 2 minutes. An increase in mean pressure, with constant pulsatile amplitude and dP/dt, produced a sustained increase in the number of spikes/cycle, in the average number of spikes/second, and in the average frequency during the burst within the cycle. In slowly adapting receptors, an increase in dP/dt at a constant mean pressure and pulsatile amplitude produced a decrease in the number of spikes/cycle and an increase in both the average number of spikes/second and the frequency during the burst. Rapidly adapting receptors showed very different characteristics, responding to a pulsatile pressure input above threshold with an irregular discharge which average...
Membrane electrical mechanism of basilar artery constriction and pial artery dilation by norepinephrine.
Authors: D RHarder, P WAbel, KHermsmeyer
Journal: Circulation Research (1981)

To study the mechanism by which norepinephrine acts on vascular muscle cell membrane, we recorded membrane potential with intracellular microelectrodes in isolated cat basilar and pial arteries. On addition of norepinephrine concentrations less than 1 microM, pial arteries hyperpolarized and relaxed while basilar arteries depolarized and contracted. Relaxation and hyperpolarization of the pial arteries occurred without the need for addition of any other drug, which indicates the relaxation of spontaneous tone. The relaxation and hyperpolarization could be completely blocked by addition of propranolol before exposure to norepinephrine. The depolarization and contraction of both basilar and pial arteries was blocked by the previous exposure to phentolamine. Electrical spikes were not found spontaneously, but could be induced in both arteries by tetraethylammonium and subsequent addition of norepinephrine, blockable by phentolamine. We conclude that membrane property differences between basilar and pial arte...
Intracardiac electrography in endocardial cushion defects.
Authors: J RJacobsen, P CGillette, B NCorbett, MRabinovitch, D GMcNamara
Journal: Circulation (1976)

Conduction of the sino-atrial impulse from the high right atrium to the ventricles was studied by intracardiac electrography in 21 unoperated patients, age 3 months to 11 years, with endocardial cushion defects (ECD). The high right atrium-to-low right atrium conduction time was prolonged in 15 of 18 subjects (mean 57 +/- 20 msec). The low right atrium-to-His bundle conduction time (LRA-H) was normal in 16 of 17 subjects (mean 82 +/- 30 msec), prolonged in one. The His-to-ventricle conduction time (H-V) was normal in 16 of 17 subjects (mean 37 +/- 8 msec), equivocally short in one. Nine patients with ECD, age 3 to 21 years, were studied postoperatively. One had an acquired complete atrioventricular block in the His bundle. Two had prolonged LRA-H and two prolonged LRA-H and two prolonged H-V. The surface ECG failed to identify accurately either prolonged atrioventricular conduction or the site of prolongation.
Alterations of K+ currents in isolated human ventricular myocytes from patients with terminal heart failure.
Authors: D JBeuckelmann, MNäbauer, EErdmann
Journal: Circulation Research (1993)

Prolongation of the action potential has been postulated to be a major reason for the altered diastolic relaxation of the heart in patients with severe heart failure. To investigate the electrophysiological basis for this action potential prolongation in terminal heart failure, K+ currents were recorded in single ventricular myocytes isolated from 16 explanted hearts of patients undergoing transplantation. Results from diseased hearts were compared with ventricular cells isolated from six undiseased donor hearts. Action potential duration was significantly prolonged in cells from patients with heart failure. A delayed rectifier K+ current was hardly detectable in most cells, and if it could be recorded, it was very small in both diseased and undiseased cells. When currents were normalized for cell surface area, the average current density of the inward rectifier K+ current was significantly reduced in diseased cells when compared with normal control cells (hyperpolarization at -100 mV, -15.9 +/- 2.2 vs -9...
Absence of t(14,18) chromosomal translocation in primary cutaneous B-cell lymphoma
Authors: E.D. Hsi, I. Mirza, R.D. Gascoyne*
Journal: British Journal of Dermatology (2002)

Journal Article Absence of t(14,18) chromosomal translocation in primary cutaneous B‐cell lymphoma Get access E.D. Hsi, E.D. Hsi Section of Hematopathology, Department of Clinical Pathology,. L‐11, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH␣44195, U.S.A. Department of Pathology, British Columbia Cancer Agency, 600 W 10th Avenue, Vancouver, BC V5Z 4E6, Canada Search for other works by this author on: Oxford Academic Google Scholar I. Mirza, I. Mirza Section of Hematopathology, Department of Clinical Pathology,. L‐11, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH␣44195, U.S.A. Department of Pathology, British Columbia Cancer Agency, 600 W 10th Avenue, Vancouver, BC V5Z 4E6, Canada Search for other works by this author on: Oxford Academic Google Scholar R.D. Gascoyne* R.D. Gascoyne* Section of Hematopathology, Department of Clinical Pathology,. L‐11, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH␣44195, U.S.A. Department of Pathology, British Columbia Cancer Agency, 600 W 10th Avenue, Vancouver, BC V5Z 4E6, Canada Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 146, Issue 6, 1 June 2002, Page 1110, https://doi.org/10.1046/j.1365-2133.2002.47329.x Published: 01 June 2002