tbuckley/cabot-search huggingface dataset:
ASSOCIATION OF HEALTH INSURANCE STATUS WITH CORONARY RISK FACTORS, CORONARY ARTERY DISEASE, INTERVENTIONS AND OUTCOMES IN INDIA: ACC-NCDR CATHPCI REGISTRY
Authors: Rajeev Gupta, Sanjeev K. Sharma, Jitender S. Makkar, Ansh Agarwal, Krishna K. Sharma, Ajeet Bana, Raghubir S. Khedar, Samin K. Sharma
Journal: Journal of the American College of Cardiology (2022)
Erratum. Risks of and From SARS-CoV-2 Infection and COVID-19 in People With Diabetes: A Systematic Review of Reviews. Diabetes Care 2021;44:2790–2811
Authors: Jamie Hartmann-Boyce, Karen Rees, James C. Perring, Sven A. Kerneis, Elizabeth M. Morris, Clare Goyder, Afolarin A. Otunla, Olivia E. James, Nandana R. Syam, Samuel Seidu, Kamlesh Khunti
Journal: Diabetes Care (2022)
INTERNATIONAL MIDA QUANTITATIVE REGISTRY, OUTCOME IMPLICATIONS OF PULMONARY HYPERTENSION IN DEGENERATIVE MITRAL REGURGITATION
Authors: Benjamin Essayagh, Giovanni Benfari, Clémence Antoine, Francesco Grigioni, Thierry Le Tourneau, Jeroen J. Bax, Victoria Delgado, Nina Ajmone Marsan, Aniek Van Wijngaarden, Christophe M. Tribouilloy, Aviram Hochstadt, Yan Topilsky, Hector I. Michelena, Maurice Enriquez-Sarano
Journal: Journal of the American College of Cardiology (2022)
Exceptional Visualization of the Gallbladder on 68Ga-DOTANOC PET/CT Imaging
Authors: Ritanshu Solanki, Harmandeep Singh, Rajender Kumar
Journal: Clinical Nuclear Medicine (2022)

Abstract Neuroendocrine tumors (NETs) are rare tumors associated with the overexpression of somatostatin receptors owing to their origin from neural crest cells. The somatostatin receptor–based molecular imaging of NETs with 68 Ga-DOTANOC is extensively used to diagnose primary and metastatic disease with high diagnostic accuracy. Unlike conventional octreotide imaging, physiological gallbladder uptake is not seen on 68 Ga-DOTANOC PET/CT imaging. The present case report exhibits the rare physiological 68 Ga-DOTANOC uptake in the gall bladder and bile duct.
COVID-19 Infection Among Incarcerated Individuals and Prison Staff in Lombardy, Italy, March 2020 to February 2021
Authors: Sara Mazzilli, Lara Tavoschi, Alessandro Soria, Marco Fornili, Giorgia Cocca, Teresa Sebastiani, Giuditta Scardina, Cristina Cairone, Guglielmo Arzilli, Giuseppe Lapadula, Luca Ceccarelli, Nicola Cocco, Raffaella Bartolotti, Stefano De Vecchi, Giacomo Placidi, Leonardo Rezzonico, Laura Baglietto, Ruggero Giuliani, Roberto Ranieri
Journal: JAMA Network Open (2022)

Owing to infrastructural and population characteristics, the prison setting is at increased risk for transmission of SARS-CoV-2 and for severe clinical outcomes. Because of structural and operational reasons, research in prison settings is challenging and available studies are often monocentric and have limited temporal coverage; broader-based research is necessary.To assess the extent and dynamics of the COVID-19 pandemic within the prison system of a large Italian region, Lombardy, and report the infection prevention and control measures implemented.This repeated cross-sectional study was carried out from March 1, 2020, through February 28, 2021 (first wave, March-June 2020; second wave, October 2020-February 2021) in the prison system of Lombardy, which includes 18 detention facilities for adults. All incarcerated persons and the prison staff of the penitentiary system of the Lombardy region participated in the study.The main exposures of interest were the weekly average number of incarcerated individuals placed in quarantine in single or shared isolation rooms, the rate of sick leave by symptomatic and asymptomatic prison staff reported to the prison occupational medicine department on a weekly basis, and the level of overcrowding.The primary outcome measures were weekly COVID-19 crude case rates, weekly test positivity rate, and the relative risk of acquiring the infection for prison staff, incarcerated persons, and the general population.The study population comprised a mean of 7599 incarcerated individuals and 4591 prison staff. Approximately 5.1% of the prison population were women; demographic characteristics of the prison staff were not available. During the study, COVID-19 occurred in 1564 incarcerated individuals and 661 prison staff. Most of these cases were reported during the second wave (1474 in incarcerated individuals, 529 in prison staff), when stringent measures previously enforced were relaxed. During both epidemic waves, incarcerated individuals and prison staff had a higher relative risk for COVID-19 infection than the general population during both the first wave (incarcerated individuals: 1.30; 95% CI, 1.06-1.58; prison staff: 3.23; 95% CI, 2.74-3.84) and the second wave (incarcerated individuals: 3.91; 95% CI, 3.73-4.09; prison staff: 2.61; 95% CI, 2.41-2.82).The findings of this study suggest that the prison setting was an element of fragility during COVID-19 pandemic, with a high burden of COVID-19 cases among both the incarcerated individuals and prison staff. The prison setting and prison population need to be included and possibly prioritized in the response during epidemic events.
Mining whole-lung information by artificial intelligence for predicting EGFR genotype and targeted therapy response in lung cancer: a multicohort study
Authors: Shuo Wang, He Yu, Yuncui Gan, Zhangjie Wu, Encheng Li, Xiaohu Li, Jingxue Cao, Yongbei Zhu, Liusu Wang, Hui Deng, Mei Xie, Yuanyong Wang, Xidong Ma, Dan Liu, Bojiang Chen, Panwen Tian, Zhixin Qiu, Jinghong Xian, Jing Ren, Kun Wang, Wei Wei, Fei Xie, Zhenhui Li, Qi Wang, Xinying Xue, Zaiyi Liu, Jingyun Shi, Weimin Li, Jie Tian
Journal: The Lancet Digital Health (2022)

Epidermal growth factor receptor (EGFR) genotype is crucial for treatment decision making in lung cancer, but it can be affected by tumour heterogeneity and invasive biopsy during gene sequencing. Importantly, not all patients with an EGFR mutation have good prognosis with EGFR-tyrosine kinase inhibitors (TKIs), indicating the necessity of stratifying for EGFR-mutant genotype. In this study, we proposed a fully automated artificial intelligence system (FAIS) that mines whole-lung information from CT images to predict EGFR genotype and prognosis with EGFR-TKI treatment.We included 18 232 patients with lung cancer with CT imaging and EGFR gene sequencing from nine cohorts in China and the USA, including a prospective cohort in an Asian population (n=891) and The Cancer Imaging Archive cohort in a White population. These cohorts were divided into thick CT group and thin CT group. The FAIS was built for predicting EGFR genotype and progression-free survival of patients receiving EGFR-TKIs, and it was evaluated by area under the curve (AUC) and Kaplan-Meier analysis. We further built two tumour-based deep learning models as comparison with the FAIS, and we explored the value of combining FAIS and clinical factors (the FAIS-C model). Additionally, we included 891 patients with 56-panel next-generation sequencing and 87 patients with RNA sequencing data to explore the biological mechanisms of FAIS.FAIS achieved AUCs ranging from 0·748 to 0·813 in the six retrospective and prospective testing cohorts, outperforming the commonly used tumour-based deep learning model. Genotype predicted by the FAIS-C model was significantly associated with prognosis to EGFR-TKIs treatment (log-rank p<0·05), an important complement to gene sequencing. Moreover, we found 29 prognostic deep learning features in FAIS that were able to identify patients with an EGFR mutation at high risk of TKI resistance. These features showed strong associations with multiple genotypes (p<0·05, t test or Wilcoxon test) and gene pathways linked to drug resistance and cancer progression mechanisms.FAIS provides a non-invasive method to detect EGFR genotype and identify patients with an EGFR mutation at high risk of TKI resistance. The superior performance of FAIS over tumour-based deep learning methods suggests that genotype and prognostic information could be obtained from the whole lung instead of only tumour tissues.National Natural Science Foundation of China.
Abstract P3-12-17: Breast cancer treatment related survival gains in the African breast cancer - Disparities in outcomes study
Authors: Milena Foerster, Eva Kantelhardt, Pauline Boucheron, Isabel dos-Santos-Silva, Valerie McCormack
Journal: Cancer Research (2022)

Abstract Background: Breast cancer (BC) survival in Low and Middle Income Countries (LMICs), and particularly Sub Saharan Africa (SSA), is low and incidence rates are increasing. Accordingly, an almost 90% increase in annual BC mortality is projected to occur until 2040. The WHO Breast Cancer Global Initiative named comprehensive breast cancer treatment as one of three main pillars to reduce BC mortality. Here, we present the urgently needed up-to-date benchmark estimates of treatment effects on BC survival in SSA using data from the African Breast Cancer Disparities in Outcomes (ABC-DO) study.Methods: Since 2014 the hospital-recruited ABC-DO cohort follows-up women diagnosed with BC in five SSA countries. Socio-demographic, diagnostic, treatment and mortality data were obtained from medical records and via three-monthly follow-up calls with the patient. Cox proportional hazard models were fitted to estimate 5-year overall survival related to treatment initiation (surgery or systemic therapy) and treatment completion as time varying variates (surgery and systemic therapy completed) stratified by country and ethnicity and separate for localised and regional tumours. All models were adjusted for age, tumour grade, tumour size, node positivity, HIV status, and socioeconomic status. Results: Of 1699 ABC-DO women with invasive non-metastatic BC, 89% initiated BC treatment (from 72% in Nigeria to 100% in South African white women). Potentially curative treatment (surgery plus systemic therapy) was initiated by 63%, 22% initiated systemic treatment and 5 % only surgery. Initiated systemic therapy was completed by 49% of patients (from 16% in Nigeria to 70 % in South African black women). Median time to first treatment was 1.4 (IQR: 0.8–3) months and differed between countries (from 1.1 (0.6–1.7) in Namibian non-black to 3 (1.5–4.3) in Uganda). After 5 years, 49% (0.44 (CI: 0.31 – 0.62) ) of women initiating any treatment and 59% (0.39 (0.27 – 0.56) of women receiving surgery and initiating systemic treatment were still alive compared to 20% of women receiving no treatment. Conclusion: Timely and comprehensive BC treatment are needed to increase the very low survival rates in SSA. Citation Format: Milena Foerster, Eva Kantelhardt, MD, Pauline Boucheron, Isabel dos-Santos-Silva, PhD, Valerie McCormack, the ABC-DO study team. Breast cancer treatment related survival gains in the African breast cancer - Disparities in outcomes study [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P3-12-17.
Quality and Safety in Health Care, Part XCV
Authors: Jay A. Harolds
Journal: Clinical Nuclear Medicine (2022)

Abstract Many times in high reliability organizations, there is uncertainty about the meaning of various happenings or circumstances. Unfortunately, in an emergency, there is often no time to fully investigate events or what is going on in the environment before action must be taken to avoid unfortunate results or disaster. In groups, sensemaking refers to the process of interrelating with others so that a shared understanding may be reached, taking advantage of the differing observations, expertise, and opinions of the people involved, and then taking appropriate action.
CHANGE IN LEFT VENTRICULAR END DIASTOLIC INDEX OR GLOBAL LONGITUDINAL STRAIN MAY PREDICT DEVELOPMENT OF CANCER THERAPY RELATED CARDIAC DYSFUNCTION IN HER2 POSITIVE BREAST CANCER PATIENTS RECEIVING TRASTUZUMAB
Authors: Rachel E. Goodman, Sarah Elizabeth Thordsen, Nithya Sridhar, Anna Calderon, Elizabeth Weil, Lubna N. Chaudhary, Sailiaja Kamaraju, Janet Retseck, John Charlson, John Burfeind, Christopher R. Chitambar, Yee Chung Cheng, Sherry-Ann Brown
Journal: Journal of the American College of Cardiology (2022)
TWO YEAR EXPERIENCE WITH HIGH-SENSITIVITY TROPONIN TESTING:INTERPRETATIVE VALUES FOR IMPROVING PATIENT DISPOSITION
Authors: John Tanaka, Harsh Patolia, Bruce Lobaugh, Candance Van Vleet, Igor Klem, Joseph Borawski, Pratik Doshi, Angela Lowenstern, L. Kristin Newby, James E. Tcheng, Jennifer Rymer
Journal: Journal of the American College of Cardiology (2022)
Immunosuppressive tumor-associated macrophages expressing interlukin-10 conferred poor prognosis and therapeutic vulnerability in patients with muscle-invasive bladder cancer
Authors: Yijia Xu, Han Zeng, Kaifeng Jin, Zhaopei Liu, Yu Zhu, Le Xu, Zewei Wang, Yuan Chang, Jiejie Xu
Journal: Journal for ImmunoTherapy of Cancer (2022)

Tumor-associated macrophages (TAMs) secreting IL-10 could be a specific functional cell subset with distinct polarization state and suppressive role in antitumor immune response. Here, we assessed the associations of clinical outcome, therapeutic responses and molecular features with IL-10+TAMs infiltration, and potential impact of IL-10+TAMs on the immune contexture in muscle-invasive bladder cancer (MIBC).In this retrospective study, 128 patients and 391 patients with MIBC from Zhongshan hospital (ZS cohort) and The Cancer Genome Atlas cohort were included respectively. Immunohistochemistry was performed to quantify various immune cell infiltration in the ZS cohort. Single cell RNA sequencing and flow cytometry were performed to examine the functional status of IL-10+TAMs and its correlation with other immune cells. Survival analyses and assessment of the adjuvant chemotherapy (ACT) benefit analyses were also performed.High IL-10+TAMs infiltration was associated with inferior prognosis in terms of overall survival and recurrence-free survival, but superior chemotherapeutic response in MIBC. IL-10+TAMs with suppressive features were associated with immunoevasive tumor microenviroment characterized by exhausted CD8+ T cells, immature NK cells and increased immune checkpoint expression. Additionally, high IL-10+TAMs infiltration showed a strong linkage with basal-featured subtype and augmented EGF signaling.Immunosuppresive IL-10+TAMs contributed to an evasive contexture with incapacitated immune effector cells and increased immune checkpoint expression, therefore, predicting unfavorable clinical outcomes despite better ACT responsiveness. IL-10+TAMs might provide guidance for customized selection of EGFR-targeted therapy, FGFR3-targeted therapy as well as immunotherapy. The potential of immunosuppressive IL-10+TAMs as a therapeutic target is worth further exploration.
HSR22-172: Immunogenicity of ChAdOx1-nCoV-19 Vaccination for Solid Cancer Patients, Prospective Observational Multicenter Study - Preliminary Report
Authors: Nattaya Teeyapun, Passakorn Passakorn Wanchaijiraboon, Nussara Pakvisal, Panot Sainamthip, Ekkamol Phaibulvatanapong, Nasamon Wanlapakorn, Yong Poovorawan, Sutima Luangdilok
Journal: Journal of the National Comprehensive Cancer Network (2022)

"HSR22-172: Immunogenicity of ChAdOx1-nCoV-19 Vaccination for Solid Cancer Patients, Prospective Observational Multicenter Study - Preliminary Report" published on 31 Mar 2022 by National Comprehensive Cancer Network.
IMPACT OF SLEEP DISORDERED BREATHING ON OVERNIGHT CHANGES OF ATRIAL STIFFNESS IN PATIENTS WITH HEART FAILURE.
Authors: Shoichiro Yatsu, Takatoshi Kasai, Hiroki Matsumoto, Jun Shitara, Azusa Murata, Shoko Suda, Akihiro Sato, Sayaki Ishiwata, Megumi Shimizu, Takao Kato, Masaru Hiki, Ryo Naito, Hiroyuki Daida
Journal: Journal of the American College of Cardiology (2022)
Large-scale decontamination of disposable FFP2 and FFP3 respirators by hydrogen peroxide vapour, Finland, April to June 2020
Authors: Katri Laatikainen, Markku Mesilaakso, Ilpo Kulmala, Erja Mäkelä, Petri Ruutu, Outi Lyytikäinen, Susanna Tella, Tarmo Humppi, Satu Salo, Tuuli Haataja, Kristiina Helminen, Henri Karppinen, Heli Kähkönen, Tarja Vainiola, Kirsimarja Blomqvist, Sirpa Laitinen, Kati Peltonen, Marko Laaksonen, Timo Ristimäki, Jouni Koivisto
Journal: Eurosurveillance (2022)

BackgroundThe shortage of FFP2 and FFP3 respirators posed a serious threat to the operation of the healthcare system at the onset of the COVID-19 pandemic.AimOur aim was to develop and validate a large-scale facility that uses hydrogen peroxide vapour for the decontamination of used respirators.MethodsA multidisciplinary and multisectoral ad hoc group of experts representing various organisations was assembled to implement the collection and transport of used FFP2 and FFP3 respirators from hospitals covering 86% of the Finnish population. A large-scale decontamination facility using hydrogen peroxide vapour was designed and constructed. Microbiological tests were used to confirm efficacy of hydrogen peroxide vapour decontamination together with a test to assess the effect of decontamination on the filtering efficacy and fit of respirators. Bacterial and fungal growth in stored respirators was determined by standard methods.ResultsLarge-scale hydrogen peroxide vapour decontamination of a range of FFP2 and FFP3 respirator models effectively reduced the recovery of biological indicators:
Risk of first ischaemic stroke and use of antidopaminergic antiemetics: nationwide case-time-control study
Authors: Anne Bénard-Laribière, Emilie Hucteau, Stéphanie Debette, Julien Kirchgesner, Julien Bezin, Antoine Pariente
Journal: BMJ (2022)

To estimate the risk of ischaemic stroke associated with antidopaminergic antiemetic (ADA) use. Case-time-control study. Data from the nationwide French reimbursement healthcare system database Système National des Données de Santé (SNDS). Eligible participants were ≥18 years with a first ischaemic stroke between 2012 and 2016 and at least one reimbursement for any ADA in the 70 days before stroke. Frequencies of ADA reimbursements were compared for a risk period (days -14 to -1 before stroke) and three matched reference periods (days -70 to -57, -56 to -43, and -42 to -29) for each patient. Time trend of ADA use was controlled by using a control group of 21 859 randomly selected people free of the event who were individually matched to patients with stroke according to age, sex, and risk factors of ischaemic stroke. Association between ADA use and risk of ischaemic stroke was assessed by estimating the ratio of the odds ratios of exposure evaluated in patients with stroke and in controls. Analyses were adjusted for time varying confounders (anticoagulants, antiplatelets, and prothrombotic or vasoconstrictive drugs). Among the 2612 patients identified with incident stroke, 1250 received an ADA in the risk period and 1060 in the reference periods. The comparison with the 5128 and 13 165 controls who received an ADA in the same periods yielded a ratio of adjusted odds ratios of 3.12 (95% confidence interval 2.85 to 3.42). Analyses stratified by age, sex, and history of dementia showed similar results. Ratio of adjusted odds ratios for analyses stratified by ADA was 2.51 (2.18 to 2.88) for domperidone, 3.62 (3.11 to 4.23) for metopimazine, and 3.53 (2.62 to 4.76) for metoclopramide. Sensitivity analyses suggested the risk would be higher in the first days of use. Using French nationwide exhaustive reimbursement data, this self-controlled study reported an increased risk of ischaemic stroke with recent ADA use. The highest increase was found for metopimazine and metoclopramide.
THE IMPACT OF EXPOSURE TO TRANSPORTATION NOISE ON THE RATES OF MYOCARDIAL INFARCTION IN NEW JERSEY
Authors: Abel E. Moreyra, Krishnamurthy Subramanian, Zhongyuan Mi, Nora M. Cosgrove, William J. Kostis, Felix Ke, John B. Kostis, Cande Ananth
Journal: Journal of the American College of Cardiology (2022)
THE EFFECT OF MAVACAMTEN ON CARDIOPULMONARY EXERCISE TESTING PERFORMANCE OF PATIENTS WITH OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY IN EXPLORER-HCM
Authors: Matthew Thomas Wheeler, Iacopo Olivotto, Perry M. Elliott, Sara Saberi, Anjali Tiku Owens, Mathew S. Maurer, Ahmad Masri, Amy Sehnert, Jay Edelberg, Wanying Li, Victoria Florea, Rajeev Malhotra, Andrew Wang, Artur Oreziak, Daniel Jacoby, Jonathan N. Myers
Journal: Journal of the American College of Cardiology (2022)
Medical Need, Financial Resources, and Transplant Accessibility
Authors: Sharad I. Wadhwani, Jennifer C. Lai, Laura M. Gottlieb
Journal: JAMA (2022)

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IS STOPPING MINERALOCORTICOID RECEPTOR ANTAGONISTS AFTER HYPERKALEMIA ASSOCIATED WITH INCREASED MORTALITY IN HEART FAILURE? A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Tariq Jamal Siddiqi, Muhammad Shariq Usman, Minaam Abid, Ritesh Menezes, Michael E. Hall, Muhammad Shahzeb Khan, Sushil Allen Luis
Journal: Journal of the American College of Cardiology (2022)
TRENDS AND OUTCOMES OF ACUTE HEART FAILURE WITH UNDERLYING AMYLOIDOSIS - A RETROSPECTIVE COHORT STUDY FROM 2016-2019 NATIONAL INPATIENT SAMPLE DATABASE
Authors: Ashiya Khan, Nischit Baral, Amith Reddy Seri, Mahin R. Khan, Hafiz Khan, Basel Abdelazeem, Govinda Adhikari, Rohit Rauniyar, Khaing Khaing Htwe, Arvind Kunadi, Hameem U. Changezi
Journal: Journal of the American College of Cardiology (2022)