tbuckley/cabot-search huggingface dataset:
Abstract 13438: Obesity is Uncommon in Patients With Transthyretin Cardiac Amyloidosis
Authors: Timothy J Poterucha, Damian Kurian, Farbod Raiszadeh, Sergio Teruya, Pierre Elias, Rebecca Kogan, Codruta Chiuzan, Andrew J Einstein, Frederick Ruberg, Mathew S Maurer
Journal: Circulation (2021)

Background: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous clinical syndrome that includes distinct subtypes with different pathophysiologies, genetics, and treatment. Distinguishing HFpEF due to transthyretin cardiac amyloidosis (ATTR-CA) is critical given its specific treatable pathophysiology. Obesity is a common driver of HFpEF, but it has been noted clinically that low body mass index (BMI) is a common finding in ATTR-CA. Methods: A single center, retrospective study of patients undergoing 99mTc-pyrophosphate (PYP) scans from 2010-2019 was analyzed for BMI association with ATTR-CA and the Val122Ile variant. BMI differences were prospectively evaluated in the ongoing multicenter Screening for Cardiac Amyloidosis Using Nuclear Imaging for Minority Populations (SCAN-MP) study. The association of BMI with ATTR-CA/Val122Ile was compared by Wilcoxon rank sum analysis and combined with age, sex, and maximum LV wall thickness in a multivariable logistic regression in both the retrospective and SCAN-MP cohorts. Results: In the retrospective analysis, BMI (in kg/m 2 ) among those with ATTR-CA/Val122Ile (n=198, 40%) was lower (25.8, IQR 23.4-28.9) than in other patients (27.1, IQR 23.9-32.0) (p&lt;0.001). In multivariable logistic regression, BMI &lt; 30 (OR 2.60, 95% CI 1.49-4.54), remained independently associated with ATTR-CA/Val122Ile. In the first 221 patients enrolled in SCAN-MP, 18 (8%) had ATTR-CA (n=11) or were carriers of the Val122Ile variant (n=7) with negative PYP scans. Among those subjects, BMI was significantly lower (25.6 [IQR 24.3-28.3]) than in other patients (32.6 [27.9-38.1]) (p&lt;0.001). BMI did not differ between ATTR-CA patients (27.5 [25.3-28.9]) and Val122Ile allele carriers with negative 99mTc-pyrophosphate scans (25.3 [24.3-28.2]). When combined with age, sex, and maximum LV wall thickness, BMI&lt;30 (OR 11.8 [CI 2.47-56.14]) and maximum LV wall thickness (OR 1.38/mm [95% CI 1.10-1.74]) were associated with ATTR-CA/Val122Ile. Conclusions: Lower BMI is associated with a diagnosis of ATTR-CA/Val122Ile in heart failure with increased LV wall thickness and may be useful in selecting patients benefiting from evaluation for ATTR-CA.
Foot Ulcer and Risk of Lower Limb Amputation or Death in People With Diabetes: A National Population-Based Retrospective Cohort Study
Authors: Rosemary C. Chamberlain, Kelly Fleetwood, Sarah H. Wild, Helen M. Colhoun, Robert S. Lindsay, John R. Petrie, Rory J. McCrimmon, Fraser Gibb, Sam Philip, Naveed Sattar, Brian Kennon, Graham P. Leese
Journal: Diabetes Care (2021)

OBJECTIVETo describe incidence of foot ulceration and amputation-free survival associated with foot ulceration status in a national population-based cohort study of people with diabetes.
High Mobility Group A1 (HMGA1) Epigenetic Regulators Induce ETV5 Networks in Relapsed B-Cell Leukemia and Provide Novel Therapeutic Targets
Authors: Jung-Hyun Kim, Liping Li, Zixin Zhang, Katharina Hayer, Lingling Xian, Li Luo, Leslie Cope, Andrei Thomas-Tikhonenko, Linda Resar
Journal: Blood (2021)
Abstract 15593: Pharmacological Inhibition of Adipose Triglyceride Lipase by Atglistatin Improves Cardiac Function in Isoproterenol-Induced Cardiomyopathy
Authors: Arne Thiele, Niklas Beyhoff, Annelie Blumrich, Daniel Ritter, Robert Klopfleisch, Jana Grune, Elia Smeir, Katja Lüttges, Beata Höft, Rudolf Zechner, Rolf Breinbauer, Ulrich Kintscher, Anna Foryst-Ludwig
Journal: Circulation (2018)

Introduction: Chronic heart failure (HF) is accompanied by elevated systemic adrenergic activity, leading to increased adipose tissue (AT) lipolysis (ATL). Our recent study implicated a promising a...
<i>NPM1</i> Mutations Do Not Retain a Favorable Prognostic Impact in Adults with Advanced Relapsed or Refractory (R/R) Acute Myeloid Leukemia (AML)
Authors: Sangeetha Venugopal, Ghayas C. Issa, Marina Konopleva, Courtney D. DiNardo, Gautam Borthakur, Elias J. Jabbour, Naveen Pemmaraju, Musa Yilmaz, Nicholas J. Short, Abhishek Maiti, Koji Sasaki, Lucia Masarova, Sherry A. Pierce, Koichi Takahashi, Guilin Tang, Sanam Loghavi, Michael Andreeff, Kapil N. Bhalla, Guillermo Garcia-Manero, Farhad Ravandi, Hagop Kantarjian, Naval Daver
Journal: Blood (2021)
Blood pressure lowering and risk of new-onset type 2 diabetes: an individual participant data meta-analysis
Authors: Milad Nazarzadeh, Zeinab Bidel, Dexter Canoy, Emma Copland, Malgorzata Wamil, Jeannette Majert, Karl Smith Byrne, Johan Sundström, Koon Teo, Barry R Davis, John Chalmers, Carl J Pepine, Abbas Dehghan, Derrick A Bennett, George Davey Smith, Kazem Rahimi
Journal: The Lancet (2021)

Blood pressure lowering is an established strategy for preventing microvascular and macrovascular complications of diabetes, but its role in the prevention of diabetes itself is unclear. We aimed to examine this question using individual participant data from major randomised controlled trials.
Abstract 14249: Trajectories of Blood Lipid Concentrations Over the Adult Life Course and Risk of Cardiovascular Disease and All-Cause Mortality
Authors: Meredith S Duncan, Ramachandran S Vasan, Vanessa Xanthakis
Journal: Circulation (2018)

Background: Elevations in circulating total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), and low concentrations of high-density lipoprotein cholesterol (HD...
Rapid and Sustained Reduction of Immunosuppressive T-Cells and Focusing of the T-Cell Repertoire in t(11;14) Relapsed/Refractory Multiple Myeloma Patients Treated with Venetoclax in Combination with Daratumumab and Dexamethasone
Authors: Nizar J. Bahlis, Jonathan L. Kaufman, Rachid Baz, Hang Quach, Shir-Jing Ho, Annette J. Vangsted, Torben Plesner, Philippe Moreau, Simon D. Gibbs, Eva Medvedova, Orlando F. Bueno, Yan Luo, Christine Mantis, Deeksha Vishwamitra, Jeremy A. Ross, Simon J Harrison
Journal: Blood (2021)
Overexpression of Human TLR8 Causes Fatal Anemia in SLE-Prone Mice By Altering the Bone Marrow Erythropoietic Niche
Authors: Anne Davidson, Naomi Maria, Julien Papoin, Chirag Raparia, Zeguo Sun, Weijia Zhang, Theodosia A. Kalfa, Robert Paulson, Lionel Blanc
Journal: Blood (2021)
<i>S. Aureus</i> Cas9 Leads to Higher Sickle Mutation Correction Compared to <i>S. Pyogenes</i> Cas9 in Patient Hematopoietic Stem and Progenitor Cells
Authors: Byoungyong Yoo, So Hyun Julie Park Park, Yankai Zhang, Vivien A. Sheehan, Gang Bao
Journal: Blood (2021)
Part 5: Adult Basic Life Support
Authors: Robert A. Berg, Robin Hemphill, Benjamin S. Abella, Tom P. Aufderheide, Diana M. Cave, Mary Fran Hazinski, E. Brooke Lerner, Thomas D. Rea, Michael R. Sayre, Robert A. Swor
Journal: Circulation (2010)

The critical lifesaving steps of BLS are ● Immediate Recognition and Activation of the emergency response system ● Early CPR and ● Rapid Defibrillation for VF. When an adult suddenly collapses, whoever is nearby should activate the emergency system and begin chest compressions (regardless of training). Trained lay rescuers who are able and healthcare providers should provide compressions and ventilations. Contrary to the belief of too many in this situation, CPR is not harmful. Inaction is harmful and CPR can be lifesaving. However, the quality of CPR is critical. Chest compressions should be delivered by pushing hard and fast in the center of the chest (ie, chest compressions should be of adequate rate and depth). Rescuers should allow complete chest recoil after each compression and minimize interruptions in chest compressions. They should also avoid excessive ventilation. If and when available, an AED should be applied and used without delaying chest compressions. With prompt and effective provision of these actions, lives are saved every day.
Impact of Polypharmacy and Potentially Inappropriate Medications Among Older Adults with Blood Cancers
Authors: Tammy T. Hshieh, Clark Dumontier, Tim Jaung, Nupur E. Bahl, Emily S. Magnavita, Chelsea E. Hawley, Lee Mozessohn, Richard M. Stone, Robert J. Soiffer, Jane Driver, Gregory A. Abel
Journal: Blood (2021)
Abstract 9203: Role of Artificial Intelligence and Utilisation of Deep Learning Methods in Screening for Subcutaneous Implantable Cardioverter Defibrillator Eligibility
Authors: Mohamed ElRefai, Mohamed AbouelAsaad, Paul Roberts
Journal: Circulation (2021)

Introduction: There is a Class I recommendation for S-ICD in patients with no pacing indication at a high risk of infection. S-ICD eligibility is assessed at pre-implant screening where ECG traces taken in multiple postures are used as a surrogate for S-ICD vectors. In HF patients undergoing diuresis, changes in electrolytes, and fluid shifts can cause changes in R and T waves amplitudes. Subsequently, T:R ratio - a major predictor of S-ICD eligibility - is dynamic. Hypothesis: We hypothesize that prolonged screening for S-ICD eligibility identifies HF patients with high probability of T wave oversensing (TWO) and inappropriate shocks that can otherwise be missed using current screening practices. Methods: We ran a prospective study where participants with structurally normal hearts and HF patients undergoing diuresis on clinical grounds were fitted with Holters®. The leads were placed to correspond to the 3 vectors of an S-ICD. We used a convolutional neural network-based model utilising phase space reconstruction matrix as a state-of-the-art tool to assess T:R ratios over 24 hours against eligibility cut-off of 1:3 based on the manufacturer screening tool. Results: A total of 21 patients (mean age 58.43 ± 18.92, 62% male) were enrolled (14 HF, 7 normal hearts). We found a significant difference in the mean and SD of the T/R ratios between both groups. Mean T/R ratio was 0.181 ± 0.084 and 0.104 ± 0.054, and SD was 0.093 ± 0.048 and 0.067 ± 0.036 in HF and normal heart groups, respectively. T/R ratio was above the eligibility threshold with medians of 4.68% (0- 64.6%) and 0.03 % (0 - 30.4%) in HF and normal heart groups, respectively. There was no difference in the mean, SD or median between leads within the same group. Conclusions: T:R ratio, a main determinant for S-ICD eligibility is higher and with more tendency to fluctuate in HF patients. We report an accurate method that utilises prolonged screening to select HF patients eligible for S-ICD with low probability of TWO and inappropriate shocks.
A Dose Escalation Phase Ia Study of Anti-CD20 Antibody Drug Conjugate, MRG001 in Relapsed/Refractory Advanced Non-Hodgkin Lymphom
Authors: Yuqin Song, Ye Guo, Zhao Wang, Meng Wu, Wei Peng, Lei Sun, Jinghui Sun, Maggie Li, Jun Zhu
Journal: Blood (2021)
Abstract PO-040: Nischarin is expressed in pancreatic ductal adenocarcinoma and is a potential target for drug repurposing
Authors: Jelena Grahovac, Marijana Pavlovic, Marija Ostojic, Kristina Zivic, Daniel Galun, Tatjana Srdic-Rajic
Journal: Cancer Research (2021)

Abstract The objective of this study was to examine the expression of Nischarin (NISCH) in pancreatic ductal adenocarcinoma (PDAC), and its potential as a target for drug repurposing. NISCH has been described as a tumor suppressor in breast and ovarian cancers, and there are several clinically approved agonists for this receptor. NISCH has also been reported as a scaffolding protein with a role in cell adhesion, invasion and metabolism – aspects of the PDAC biology that are of interest for therapeutical intervention. We examined mRNA and protein expression of NISCH in publicly available datasets, patient tumor samples, representative PDAC cell lines and patient-derived stellate cells. We found that NISCH is a prognostic marker in PDAC patients and that it is expressed in both cancer cells and cancer-associated stroma. Gene set enrichment analysis showed that NISCH expression was associated with the regulation of cell motility, cell cycle and energy metabolism. Indeed, NISCH knockdown in cancer cells induced reorganization of the actin cytoskeleton. Next, we tested the effects of three clinically approved NISCH agonists (rilmenidine, clonidine and moxonidine) on cancer cells and cancer-associated fibroblasts (CAFs). We found that rilmenidine, agonist with the highest affinity for the NISCH receptor, had the most potent effect. Rilmenidine impaired cancer cell adhesion, limited migration and decreased production of pro-metastatic cytokines and extracellular matrix deposition in cancer cell-CAF co-cultures. Our study lays a ground for more extensive examination of the role of NISCH in PDAC and implies that NISCH agonists may be good candidates for drug repurposing in this type of cancer. Citation Format: Jelena Grahovac, Marijana Pavlovic, Marija Ostojic, Kristina Zivic, Daniel Galun, Tatjana Srdic-Rajic. Nischarin is expressed in pancreatic ductal adenocarcinoma and is a potential target for drug repurposing [abstract]. In: Proceedings of the AACR Virtual Special Conference on Pancreatic Cancer; 2021 Sep 29-30. Philadelphia (PA): AACR; Cancer Res 2021;81(22 Suppl):Abstract nr PO-040.
Acquired Hemophilia a Relapse Is Related to Th2 Response, and Increased Expression of B-Cell Activating Factor (BAFF)
Authors: Jessica O Frade-Guanaes, Ana P Racanelli, Lucia H Siqueira, Carolina Costa-Lima, Samuel S Medina, Nivia M Foschi, Marina P Colella, Silmara A L Montalvão, Gabriela G Yamaguti-Hayakawa, Margareth C Ozelo
Journal: Blood (2021)
Update on Pediatric non-Postoperative Junctional Ectopic Tachycardia.
Authors: Maldonado Sebastian, Albaca Guadalupe, Lafuente María Victoria, Benjamin Monica, Lopez Jinete Darues, Guerchicoff Marianna, Sciegata Alberto
Journal: Clinical Cardiology and Cardiovascular Interventions (2019)

Junctional ectopic tachycardia (JET) is a rare supraventricular tachycardia more frequently seen in pediatric patients which is associated with high morbidity and mortality without an adequate treatment. Its treatment often requires multiple drugs for arrhythmia control and, in some cases, a cryoablation is indicated. Some patients may revert to sinus rhythm spontaneously after long periods on antiarrhythmic drug. Currently, the arrhythmia prognosis has improved significantly since cryoablation development and the implementation of a more aggressive pharmacological treatment strategy. The purpose of this review is to describe the natural history of idiopathic JET and treatment advances.
EZH1/2 Dual Inhibitor Valemetostat Tosylate (DS-3201b) Acts Differently from EZH2 Selective Inhibitor on Epigenetic Landscape to Exert Greater Anti-Tumor Effect Against Diffuse Large B-Cell Lymphoma
Authors: Toshihiro Banjo, Yasuhiro Hama, Emi Nosaka, Yoshimi Takata, Daisuke Honma, Mayumi Kitagawa, Yuka Yamamoto, Chisa Wada, Takanori Yoshida, Kyungtaek Lim, Atsushi Okamoto, Erina Sato, Yumiko Katayama, Kazumi Sato, Hiroki Goto, Yuki Abe
Journal: Blood (2021)
EPOR/JAK/STAT Signaling Pathway As Therapeutic Target of Acute Erythroid Leukemia
Authors: June Takeda, Kenichi Yoshida, Masahiro Marshall Nakagawa, Yasuhito Nannya, Akinori Yoda, Daisuke Morishita, Ryunosuke Saiki, Kenichi Chiba, Hiroko Tanaka, Yuichi Shiraishi, Ming-Chung Kuo, Cassandra M Kerr, Yasunobu Nagata, Nobuhiro Hiramoto, Akira Hangaishi, Hideyuki Nakazawa, Ken Ishiyama, Satoru Miyano, Shigeru Chiba, Yasushi Miyazaki, Toshiyuki Kitano, Kensuke Usuki, Nobuo Sezaki, Hisashi Tsurumi, Shuichi Miyawaki, Jaroslaw P. Maciejewski, Takayuki Ishikawa, Kazuma Ohyashiki, Arnold Ganser, Michael Heuser, Felicitas Thol, Lee-Yung Shih, Akifumi Takaori-Kondo, Hideki Makishima, Seishi Ogawa
Journal: Blood (2021)
Clinical Features and Treatment Outcomes of Large Granular Lymphocytic Leukemia Coexisting with Autoimmune Diseases
Authors: Ning Dong, Franco Castillo Tokumori, Leidy Isenalumhe, Yumeng Zhang, Ankita Tandon, Todd C. Knepper, Haipeng Shao, Ling Zhang, Lubomir Sokol
Journal: Blood (2021)
Abstract 9417: Prognostic Value and Predictors of Right Ventricular Dysfunction by Magnetic Resonance Imaging in Non-Ischemic Cardiomyopathy
Authors: Tom Wang, Duygu Kocyigit, Nicholas Chan, Chris Anthony, Jennifer Bullen, Zoran B Popovic, Wai Hong W Tang, Brian P Griffin, Scott D Flamm, Deborah H Kwon
Journal: Circulation (2021)

Background: Challenges remain in our understanding of implications of right ventricle (RV) dysfunction in heart failure. Cardiac magnetic resonance imaging (CMR) is the reference standard for RV quantification, but has seldomly been studied for this purpose in cardiomyopathy patients. We evaluated the predictors and outcomes of reduced CMR-derived right ventricle function in non-ischemic cardiomyopathy (NICM). Methods: Adult NICM patients undergoing CMR quantifying the RV during 2002-2017 were retrospectively studied. Multivariable linear and Cox proportional hazards regression were used to identify factors associated with reduced RV ejection fraction (RVEF) and adverse outcomes. The primary endpoint was all-cause mortality, heart transplant and/or left ventricular assist device implantation. Results: Amongst 624 NICM patients, mean age was 52.7±15.9 years, 253 (40.5%) were female, and RVEF was 43±13%. Factors independently associated with RVEF (beta-coefficients, P-values) were male (-3.26, P&lt;0.001), New York Heart Association Class (-1.78, P=0.003), left ventricular ejection fraction (0.39, P&lt;0.001), right ventricular end-diastolic volume indexed (-0.15, P&lt;0.001), and mitral regurgitant fraction (MR-RF) (-0.18, P&lt;0.001). Reduced RVEF was independently associated with the primary endpoint (occurring in 113 (18.1%) patients), hazards ratio 0.81 (95% confidence interval 0.74-0.89), with other predictors being age, diabetes, late gadolinium enhancement score and MR-RF(Table). Prognostic thresholds for clinically significant and severe RVEF were determined to be RVEF≤43% and ≤31% respectively. Conclusion: Reduced RVEF was prevalent in NICM patients, and was independently associated with worse prognosis in NICM. Important clinical and CMR factors associated with lower RVEF were identified, as well as the optimal prognostic RVEF thresholds.
The International Hemoglobinopathy Research Network (INHERENT): An International Initiative to Study the Role of Genetic Modifiers in Hemoglobinopathies
Authors: Petros Kountouris, Coralea Stephanou, Natasha M. Archer, Fedele Bonifazi, Viviana Giannuzzi, Kevin H.M. Kuo, Aurelio Maggio, Julie Makani, Maria Del Mar Mañú Pereira, Kyriaki Michailidou, Siana Watoky Nkya, Obiageli E Nnodu, Sara Trompeter, Leon Tshilolo, Ambroise Wonkam, Bin Alwi Zilfalil, Baba PD Inusa, Marina Kleanthous
Journal: Blood (2021)
Basic ultrasound head-to-toe skills for intensivists in the general and neuro intensive care unit population: consensus and expert recommendations of the European Society of Intensive Care Medicine 
Authors: Chiara Robba, Adrian Wong, Daniele Poole, Ashraf Al Tayar, Robert T. Arntfield, Michelle S. Chew, Francesco Corradi, Ghislaine Douflé, Alberto Goffi, Massimo Lamperti, Paul Mayo, Antonio Messina, Silvia Mongodi, Mangala Narasimhan, Corina Puppo, Aarti Sarwal, Michel Slama, Fabio S. Taccone, Philippe Vignon, Antoine Vieillard-Baron, Chiara Robba, Adrian Wong, Daniele Poole, Ashraf Al Tayar, Robert T Arntfield, Michelle S Chew, Francesco Corradi, Ghislaine Douflé, Alberto Goffi, Massimo Lamperti, Paul Mayo, Antonio Messina, Silvia Mongodi, Mangala Narasimhan, Corina Puppo, Aarti Sarwal, Michel Slama, Fabio S Taccone, Philippe Vignon, Antoine Vieillard-Baron
Journal: Intensive Care Medicine (2021)

To provide consensus, and a list of experts' recommendations regarding the basic skills for head-to-toe ultrasonography in the intensive care setting. The Executive Committee of the European Society of Intensive Care (ESICM) commissioned the project and supervised the methodology and structure of the consensus. We selected an international panel of 19 expert clinicians–researchers in intensive care unit (ICU) with expertise in critical care ultrasonography (US), plus a non-voting methodologist. The panel was divided into five subgroups (brain, lung, heart, abdomen and vascular ultrasound) which identified the domains and generated a list of questions to be addressed by the panel. A Delphi process based on an iterative approach was used to obtain the final consensus statements. Statements were classified as a strong recommendation (84% of agreement), weak recommendation (74% of agreement), and no recommendation (less than 74%), in favor or against. This consensus produced a total of 74 statements (7 for brain, 20 for lung, 20 for heart, 20 for abdomen, 7 for vascular Ultrasound). We obtained strong agreement in favor for 49 statements (66.2%), 8 weak in favor (10.8%), 3 weak against (4.1%), and no consensus in 14 cases (19.9%). In most cases when consensus was not obtained, it was felt that the skills were considered as too advanced. A research agenda and discussion on training programs were implemented from the results of the consensus. This consensus provides guidance for the basic use of critical care US and paves the way for the development of training and research projects.
Characteristics and Outcomes of Adult Patients with Malignancy-Associated Hemophagocytic Lymphohistiocytosis: A Single-Center, Prospective Analysis
Authors: Shehab Fareed Mohamed, Rita Assi, Jing Ning, Lianchun Xiao, Elias J. Jabbour, Naveen Pemmaraju, Tapan M. Kadia, Nitin Jain, Courtney D. DiNardo, Musa Yilmaz, Abhishek Maiti, Ghayas C. Issa, Nicholas J. Short, Prithviraj Bose, Lucia Masarova, Guillermo Garcia-Manero, Farhad Ravandi, Marina Konopleva, Hagop Kantarjian, Naval Daver
Journal: Blood (2021)