tbuckley/cabot-search huggingface dataset:
Letter to the editor: Treatment options for 3–5‐cm solitary HCC—Need a closer look!
Authors: Ankur Jindal, Amar Mukund
Journal: Hepatology (2022)

To the editor, We read with great interest the retrospective study by Wang et al. comparing the efficacy and safety of patients undergoing laparoscopic liver resection (LLR) versus microwave ablation (MWA) for solitary 3–5‐cm HCC.[1] Despite better disease‐free survival with LLR, the overall survival and severe adverse effect profiles were similar. The authors also suggested that MWA might be considered as a first‐line alternative to LLR, with technical advances especially for patients unsuitable for LLR. Some of the issues need further consideration. First, over ~80% patients in the study cohort had no portal hypertension. For these patients, LLR prevails over local ablation for 3–5‐cm HCC with lower rates of tumor recurrence and 5‐year mortality.[2] Denying LLR as first‐line treatment in these "ideal" candidates is not justified. The study should have carefully compared LLR and MWA for high‐risk individuals alone. These include patients with deep‐seated HCC, high albumin‐bilirubin score, presence of portal hypertension, and possibly poor tumor biology.[3] In these cases, up‐front liver transplantation is desirable but not always available, and both LLR and MWA have suboptimal safety and/or efficacy. It is hard to believe that despite the presence of portal hypertension in ~15% patients undergoing LLR, only one had liver failure. Furthermore, the comparison of LLR outcomes based on tumor locations and resection approach is desirable. Second, complete tumor ablation for 3–5‐cm HCC is essential as overall patient survival based on tumor response after MWA is an important prognostic factor. With technical advances, different MWA devices seem to produce substantial differential ablation volumes and shapes; however, complete ablation using single antenna may be produced mostly for 3‐cm lesions, and larger lesions do require placement of multiple antennas in a specified fashion for achieving complete ablation (having a 5‐mm margin of adjoining normal liver parenchyma and simultaneously preserving normal parenchyma), which may be challenging at times. To overcome this issue, MWA is increasingly being combined with transarterial chemoembolization (TACE) to achieve complete ablation in tumors > 3 cm.[4] The study should have elaborated on the overall and disease‐free survival outcomes in patients requiring repeat MWA for incomplete ablation and/or residual lesions and for those requiring the next suitable option such as TACE after tumor recurrence. Third, almost 80% of patients had HCC related to chronic hepatitis B infection, but only 40% were on antiviral therapy at enrollment. Whether these clinical outcomes could be generalized to HCC from other emerging causes such as alcohol use and metabolic‐associated fatty liver disease remains to be determined. Over 10% patients had missing long‐term prognostic data on tumor recurrence. Biases due to the retrospective study nature and data loss after propensity matching remain inevitable. CONFLICT OF INTEREST Nothing to report.
BUREAU OF LEGAL MEDICINE AND LEGISLATION
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Value of k12 for Lidocaine
Journal: JAMA (1977)

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Association of Oncology Care Model Participation With Medicare Payments, Utilization, Care Delivery, and Quality Outcomes
Authors: Ronald D. Ennis
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Update: Trends in Fetal Alcohol Syndrome— United States, 1979-1993
Journal: JAMA (1995)

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Synergistically Detachable Microneedle Dressing for Programmed Treatment of Chronic Wounds
Authors: Tianqin Ning, Fenghe Yang, Danli Chen, Zhenzhen Jia, Rongqing Yuan, Zhenqin Du, Shuaiyin Liu, Yao Yu, Xiaochuan Dai, Xufeng Niu, Yubo Fan
Journal: Advanced Healthcare Materials (2022)

Chronic wounds such as diabetic feet undergo a lifetime risk of developing into incurable ulcers. Current treatments for chronic wounds remain unsatisfactory due to the lack of ideal wound dressings that integrate facile dressing change, long-acting treatment, and high therapeutic efficacy into one system. Herein, a synergistically detachable microneedle (MN) dressing with a dual-layer structure is presented to enable programmed treatment via one-time dressing application. Such a dual-layer dressing MN system (DDMNS) is composed of chitosan (CS) hydrogel dressing (CSHD) on top of a detachable MN patch with a CS tip and a polyvinyl pyrrolidone (PVP) backing substrate incorporated with magnesium (Mg). The synergistic detachment is achieved with the backing Mg/PVP substrate dissolving within minutes due to the local moist environment of the CSHD enhancing the reaction between Mg and inflammation microenvironment. The combined treatment of Mg and panax notoginseng saponins (PNS) loaded in DDMNS achieves antibacterial, neovascularization, and activating a benign immune response so that the three overlapping periods of the inflammation, tissue proliferation, and tissue remodeling of wound healing reach a dynamic balance. This advanced DDMNS provides a facile approach for the programmed treatment of chronic wound management indicating potential value in wound healing and other related biomedical fields.
Data-driven subgroups of type 2 diabetes, metabolic response, and renal risk profile after bariatric surgery: a retrospective cohort study
Authors: Violeta Raverdy, Ricardo V Cohen, Robert Caiazzo, Helene Verkindt, Tarissa Beatrice Zanata Petry, Camille Marciniak, Benjamin Legendre, Pierre Bauvin, Estelle Chatelain, Alain Duhamel, Elodie Drumez, Naima Oukhouya-Daoud, Mikael Chetboun, Gregory Baud, Emma Ahlqvist, Niels Wierup, Olof Asplund, Blandine Laferrère, Leif Groop, FranÇois Pattou
Journal: The Lancet Diabetes & Endocrinology (2022)
Squeezing causes less scarring than phenol ablation in molluscum contagiosum
Journal: BMJ (1999)

Alcohol lowers risk of heart disease through effect on lipids and haemostatic factors Results from observational studies provide strong evidence that people who drink moderate amounts of alcohol have a lower risk of developing coronary heart disease than those who abstain, but some have suggested that this association is spurious.Rimm et al (p 1523) conducted a meta-analysis of all experimental studies of alcohol intake to summarise the effects of alcohol on lipid and haemostatic factors and to explain the inverse association between alcohol intake and risk of coronary disease.With an alcohol intake of 30 g a day the authors project a 24.7% reduction in risk of coronary heart disease mediated through changes in concentrations of high density lipoprotein cholesterol, fibrinogen, and triglyceride.
The Cover
Authors: M. Therese Southgate
Journal: JAMA (1995)

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VITAMIN D IN TUBERCULOSIS
Journal: JAMA (1930)

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AMA Insights
Journal: JAMA (1985)

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Error in Author’s Name
Authors: Frans Van Workum, Moniek Verstegen, Camiel Rosman
Journal: JAMA Surgery (2022)

M. Margaret Knudson, MD; Ernest E. Moore, MD; Lucy Z. Kornblith, MD; Amy M. Shui, MA; Scott Brakenridge, MD; Brandon R. Bruns, MD; Mark D. Cipolle, MD; Todd W. Costantini, MD; Bruce A. Crookes, MD; Elliott R. Haut, MD; Andrew J. Kerwin, MD; Laszlo N. Kiraly, MD; Lisa M. Knowlton, MD; Matthew J. Martin, MD; Michelle K. McNutt, MD; David J. Milia, MD; Alicia Mohr, MD; Ram Nirula, MD; Fredrick B. Rogers, MD; Thomas M. Scalea, MD; Sherry L. Sixta, MD; David A. Spain, MD; Charles E. Wade, PhD; George C. Velmahos, MD
THE PUBLIC SERVICES.
Journal: JAMA (1896)

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Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis
Authors: Andreas Rowald, Salif Komi, Robin Demesmaeker, Edeny Baaklini, Sergio Daniel Hernandez-Charpak, Edoardo Paoles, Hazael Montanaro, Antonino Cassara, Fabio Becce, Bryn Lloyd, Taylor Newton, Jimmy Ravier, Nawal Kinany, Marina D’Ercole, Aurélie Paley, Nicolas Hankov, Camille Varescon, Laura McCracken, Molywan Vat, Miroslav Caban, Anne Watrin, Charlotte Jacquet, Léa Bole-Feysot, Cathal Harte, Henri Lorach, Andrea Galvez, Manon Tschopp, Natacha Herrmann, Moïra Wacker, Lionel Geernaert, Isabelle Fodor, Valentin Radevich, Katrien Van Den Keybus, Grégoire Eberle, Etienne Pralong, Maxime Roulet, Jean-Baptiste Ledoux, Eleonora Fornari, Stefano Mandija, Loan Mattera, Roberto Martuzzi, Bruno Nazarian, Stefan Benkler, Simone Callegari, Nathan Greiner, Benjamin Fuhrer, Martijn Froeling, Nik Buse, Tim Denison, Rik Buschman, Christian Wende, Damien Ganty, Jurriaan Bakker, Vincent Delattre, Hendrik Lambert, Karen Minassian, Cornelis A. T. van den Berg, Anne Kavounoudias, Silvestro Micera, Dimitri Van De Ville, Quentin Barraud, Erkan Kurt, Niels Kuster, Esra Neufeld, Marco Capogrosso, Leonie Asboth, Fabien B. Wagner, Jocelyne Bloch, Grégoire Courtine
Journal: Nature Medicine (2022)
BERLIN LETTER.
Journal: JAMA (1884)

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The Environment
Authors: Charles I. Baron
Journal: JAMA (1971)

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Occupational Medicine
Journal: JAMA (2000)

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"MELLON ISSUES BEER REGULATIONS"
Journal: JAMA (1921)

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