tbuckley/cabot-search huggingface dataset:
Efficacy of medical treatments for vernal keratoconjunctivitis: A systematic review and meta-analysis
Authors: Inès Roumeau, Adrien Coutu, Valentin Navel, Bruno Pereira, Julien S. Baker, Frédéric Chiambaretta, Dominique Bremond-Gignac, Frédéric Dutheil
Journal: Journal of Allergy and Clinical Immunology (2021)
Postnatal age-related renal responses to hypoxemia in lambs.
Authors: D NWeismann, W RClarke
Journal: Circulation Research (1981)

The role of normocapnic hypoxemia (arterial PO2 33 +/- 7 torr for 30 minutes) in asphyxial renal failure and its modification by maturation of renal function was studied in 50 chronically catheterized, unanesthetized lambs of 2-38 days postnatal age. Arterial pH and PCO2 did not change significantly in response to hypoxemia in these lambs. Normocapnic hypoxemia was associated with (1) significant percent increases in arterial serum osmolality (1.82 +/- 2.96%, P = 0.0001), arterial blood lactate concentration (1009 +/- 2092%, P = 0.0018), arterial blood hematocrit (6 +/- 12%, P = 0.0016), arterial hemoglobin concentration (4.6 +/- 6.5%, P = 0.0004), arterial plasma vasopressin (2370 +/- 3340%, P = 0.0001), arterial plasma renin activity (153 +/- 230%, P = 0.0001), arterial plasma aldosterone (91.3 +/- 143%, P = 0.0001), and fractional sodium excretion rate (120 +/- 240%, P = 0.007); and (2) significant percent decline in glomerular filtration rate (-22.6 +/- 32.6%, P = 0.0003). Several responses to hypoxem...
Standardization of Medical Records
Journal: BMJ (1965)

the intro- duction of oral contraceptives has been highly successful in many parts of Africa.The " pill " is aesthetically acceptable (attendance of Indian women at Natal Family Clinics was 14,000 in 1963, 28,000 in 1964), but for a large minority of Asian or African women the intrauterine device is, for various reasons, a suitable alternative.But the family planning clinics from which these contraceptives are as yet available are situated in the larger towns.Very little contraception is undertaken in rural areas because of the shortage of staff, etc.The criticisms by NMr.Stallworthy or bfy Mr. Corbett of the suitability of either con- traceptive for use in Africa suggest a conflict of choice where none in fact exists.They seem to merge, or identify, the problem of
Ventricular aneurysms complicating coxsackievirus group B, types 1 and 4 murine myocarditis.
Authors: M REl-Khatib, J LChason, A MLerner
Journal: Circulation (1979)

Suckling Swiss Webster mice were inoculated with 10(4)TCD50 of coxsackieviruses, group B types 1 or 4. Virulent necrotizing myocarditis resulted in 185 infected mice. Of the latter group, three (14.3%) nurslings on the 17th and 23rd day after inoculations had left ventricular aneurysms postmortem. None of 61 concurrently matched control mice developed aneurysms. Ventricular aneurysm is a suggested but previously undocumented complication of murine, and possibly human necrotizing transmural coxsackievirus myocarditis.
Fibrinolytic effects of intracoronary streptokinase administration in patients with acute myocardial infarction and coronary insufficiency.
Authors: M JCowley, AHastillo, G WVetrovec, L MFisher, RGarrett, M LHess
Journal: Circulation (1983)

Serial coagulation studies were obtained in 25 patients treated with intracoronary streptokinase infusion for myocardial infarction (23 patients) or coronary insufficiency (two patients) to determine the frequency of systemic fibrinolytic activity. Clotting studies were obtained before and after infusion and at 4-hour intervals until normalization. Intracoronary thrombolysis was successful in 20 of 23 patients (87%) with myocardial infarction. Streptokinase dosage in this study was 201,000 +/- 74,000 IU (+/- SD). Systemic fibrinolytic activity, defined as greater than 70% reduction of fibrinogen using a functional assay (Claus method), occurred in 22 of 25 patients (88%) and was present at a mean streptokinase dosage of 119,000 +/- 52,000 IU. Fibrinogen in the total population decreased from 342 +/- 80 to 87 +/- 94 mg% (p less than 0.0001). In patients with systemic effect, the mean fibrinogen level after infusion was 17% of baseline, increased to 43% at 24 hours, and returned to normal at 30 hours. Plasm...
When progressing training loads, what are the considerations for healthy and injured athletes?
Authors: Tim Gabbett, Igor Sancho, Bart Dingenen, Richard W Willy
Journal: British Journal of Sports Medicine (2021)

Every sport requires specific physical capacities to enable success and minimise injury risk. For instance, a competitive runner requires adequate muscular force production to counter ground reaction forces for a single step at a given speed ( local tissue capacity), and the muscular and cardiovascular endurance to tolerate the accumulation of steps for the time and distance of the event ( sport-specific capacity). Failing to adequately develop these physical qualities may result in underperformance and/or increased injury risk. In this editorial we explore how to optimally monitor and progress training loads to improve local tissue and sport-specific capacity.

When referring to load capacity, sport-specific capacity is defined as the athlete’s ability to perform (and withstand) the demands of training and competition, whereas local tissue capacity is defined as a specific structure’s ability to withstand tissue-specific cumulative load.1 In healthy athletes, training load quantification focuses on the athlete’s sport-specific capacity and not on one’s specific local tissue capacity. Progressively applied sport-specific training load improves an athlete’s physical capacities (eg, strength, power and endurance) and performance.2 Conversely, injury risk increases if training loads grossly exceed the athlete’s current local tissue capacity.3 Thus, increasing local tissue capacity as a component of the training cycle can decrease injury risk.

Loading for healthy athletes is designed to improve sport-specific …
Abstract 16384: Dual Microrna-Targeting Rescues the Impaired Mitochondrial Unfolded Protein Response in Heart Failure
Authors: Marco Morelli, Xujun Wang, Alessandro Matarese, Christopher Chavez, Gaetano Santulli
Journal: Circulation (2019)

Introduction: The mitochondrial unfolded protein response (UPRmt) is an evolutionary conserved process evoked when the mitochondrial protein folding environment is compromised. The major regulators...
Allen's Commercial Organic Analysis. A treatise on the properties, modes of assaying, and proximate analytical examination of the various organic chemicals and products employed in the arts, manufactures, medicine, etc., with concise methods for the detection and estimation of their impurities, adulterations, and products of decomposition.
Journal: JAMA (1926)

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Antiarrhythmic efficacy, clinical electrophysiology, and pharmacokinetics of 3-methoxy-O-desmethyl encainide (MODE) in patients with inducible ventricular tachycardia or fibrillation.
Authors: D MRoden, J TLee, R LWoosley, D SEcht
Journal: Circulation (1989)

In most patients, the clinical effects of therapy with encainide are mediated by the generation of the active metabolites O-desmethyl encainide and 3-methoxy-O-desmethyl encainide (MODE). Data from in vitro and animal studies have indicated that MODE has electrophysiologic and pharmacokinetic features that make its further evaluation desirable; in earlier studies, we found that MODE suppressed chronic high-frequency nonsustained ventricular arrhythmias at plasma concentrations of 50-160 ng/ml. We now report the clinical electrophysiology, antiarrhythmic activity, and pharmacokinetics of MODE in 17 patients with inducible ventricular tachyarrhythmias (VTs) in whom programmed electrical stimulation was performed before drug administration and after one or two sequences of loading and maintenance infusions of MODE. Because the relation between plasma concentration and effect had been incompletely defined, a dose-titration approach was adopted: available pharmacokinetic data were used to construct loading and...
Effect of physical training on exercise-induced hyperkalemia in chronic heart failure. Relation with ventilation and catecholamines.
Authors: C WBarlow, M SQayyum, P PDavey, JConway, D JPaterson, P ARobbins
Journal: Circulation (1994)

BACKGROUNDThe exercise-induced rise in arterial potassium concentration ([K+]a) may contribute to exercise hyperpnea and could play a role in exertional fatigue. This study was designed to determine whether the exercise-induced rise in [K+]a is altered in patients with chronic heart failure (CHF) and whether physical training affects K+ homeostasis.METHODS AND RESULTSWe evaluated 10 subjects with CHF (ejection fraction, 23 +/- 3.9%) and 10 subjects with normal left ventricular function (NLVF) who had undergone previous coronary artery graft surgery (ejection fraction, 63 +/- 8.6%). Subjects performed an incremental cycle ergometer exercise test before and after a physical training or detraining program. Changes in [K+]a and ventilation (VE) during exercise were closely related in both groups. Subjects with CHF did less absolute work and had reduced maximal oxygen consumption (VO2max) compared with subjects with NLVF (P < .01). Exercise-induced rises in [K+]a, VE, norepinephrine, lactate, and heart rate we...
Myocardial adrenergic denervation supersensitivity depends on a postreceptor mechanism not linked with increased cAMP production.
Authors: H KHammond, D ARoth, C EFord, G WStamnas, M GZiegler, CEnnis
Journal: Circulation (1992)

BACKGROUNDTwo major hypotheses have been proposed to explain catecholamine supersensitivity after myocardial denervation, but neither sufficiently explains certain features of the phenomenon. In addition, a nonsurgical method for long-term myocardial adrenergic denervation is desirable but has not been accomplished or described with respect to catecholamine supersensitivity.METHODS AND RESULTSWe have accomplished chronic myocardial adrenergic denervation by using 6-hydroxydopamine (6-OHDA). Sixteen weeks after 6-OHDA administration to newborn pigs, we found substantial myocardial adrenergic denervation associated with beta-adrenergic receptor (beta AR) downregulation. Despite decreased beta AR number, the dose of isoproterenol yielding 50% maximal heart rate change (ED50) was decreased, and heart rates during exercise showed increased responsiveness despite decreased circulating catecholamines. Thus, stimulation of fewer receptors yielded an increased response, implying improved signal transduction effici...
125P Benefit of immunotherapy in advanced NSCLC patients selected by KRAS mutations: A single institute retrospective analysis
Authors: J.J. Soto Castillo, E. Corral de la Fuente, M.E. Olmedo García, A. Gómez Rueda, Y. Lage, E.M. Vida Navas, L. Sanz Gómez, M. Lario, P. Garrido Lopez
Journal: Journal of Thoracic Oncology (2021)
Primary and secondary sexual health services need a consistent philosophy
Authors: P. Greenhouse
Journal: BMJ (1995)

EDITOR,—Sexual health care integrates the promotion of sexual health with the provision of services for its maintenance. Thus it combines education on reducing risks and promoting health seeking behaviour with clinical care for contraception, abortion, sexually transmissible diseases, and the wide range of associated problems in one service. The need for integrated or holistic sexual health care is not a sudden, recent development but one that has been obvious to a minority of concerned doctors …
Endoscopic Versus Surgical Approach to the Management of Pain in Chronic Pancreatitis: Systematic Review and Meta Analysis
Authors: PJ Ortiz Mendieta, VM Takamatsu Sagae, I Braga Ribeiro, B Salomão Hirsch, MV Cury Vieira, DTH de Moura, SA Sánchez-Luna, W Marques Bernardo, R Silva de Paula Rocha, T Arantes de Carvalho Visconti, E Guimarães Hourneaux de Moura
Journal: Endoscopy (2021)

Aims The formation of stones or stenosis in the main pancreatic duct are complications of chronic pancreatitis associated with pain, which has a great impact on the quality of life of the patient, leading to frequent hospital admissions. The objective of this study is to gather the evidence available in the literature comparing endoscopic and surgical therapy for its management.
Transcutaneous angioplasty of experimental aortic coarctation.
Authors: J ELock, TNiemi, B ABurke, SEinzig, W RCastaneda-Zuniga
Journal: Circulation (1982)

A dilatable form of juxtaductal aortic coarctation was surgically created in 29 newborn lambs. Of the 17 long-term survivors, four lambs served as controls and 13 underwent transcutaneous balloon dilation angioplasty with either polyvinylchloride or polyethylene catheters after 7--10 weeks of recovery. During growth before dilation, there was little change in the systolic gradient across the coarctation (36.6-35.3 mm Hg) despite an increase in animal weight from 3.8 to 19.3 kg. This systolic gradient remained constant in undilated lambs throughout a 6-month follow-up. Dilation produced an immediate 65% increase in the diameter of the coarctation and a 68% decrease in the systolic gradient across the coarctation site. Successful dilation required very high (6--8 atmospheres) dilating pressures. This gradient relief persisted throughout a follow-up of up to 1 year. Although no late sequelae could be attributed to the angioplasty, one lamb suffered an anterior aortic tear (associated with a difficult postdil...
Synergistic effect of combination treatment with MI-219, a small molecule inhibitor of the MDM2-p53 interaction, and kinase inhibitors or chemotherapeutic agents.
Authors: Guangfeng Wang, Ting Zhang, Ping Min, Yan Zhang, Xinyan Ni, Hengbang Wang, Jia Wang, Sanmao Kang, Lidong Xing, Xiaolan Ling, Nathalie Bruey-Sedano, Dajun Yang
Journal: Cancer Research (2008)

5655  Targeting the MDM2-p53 interaction to reactivate p53 tumor suppressor function in cancer using small-molecule inhibitors is a new strategy for anti-cancer drug development. MI-219 is developed as a highly potent and orally bioavailable small molecule inhibitor of the MDM2-p53 interaction. Cell growth inhibition was measured using WST-based assays. The CalcuSyn program was used to calculate the Combination Index (CI) value (CI value 10,000-fold selectivity over other protein-protein interactions. MI-219 induced a dose-dependent growth inhibition in wt-p53 cancer cell lines with a mean IC50 of 2.65 uM in A549, 3.566 uM in H460, 2.20 uM in RKO, 1.75 uM in SJSA-1, and 5.14 uM in BC-3. MI-219 demonstrated strong synergy with targeted agents, such as the EGFR kinase inhibitor erlotinib, against NSCLC lines A549 (CI value=0.48) and H460 (CI value=0.8). Synergy was also observed with irinotecan against the colon cancer line RKO (CI value = 0.76) and against A549 (CI value=0.55). When dosed at 50 mg/kg in mice, MI-219 had an oral bioavailability of 55% with t1/2 of 1.6 hours and a Cmax of 17.3 uM. MI-219 was stable in plasma of mice, rats, dogs and monkeys. Tissue distribution studies further demonstrated that following oral administration of MI-219, there was a wide and rapid distribution in the body and excellent penetration into tumor tissues. Consistent with its high binding affinity and excellent PK and PD profiles, when given at optimal doses for 14 days, MI-219 was capable of completely stopping tumor growth or inducing partial tumor regression as a single agent. Combined treatment with MI-219 and irinotecan synergistically suppressed SJSA-1 cells tumor growth compared with treatment of either agent alone. The combination showed anti-tumor efficacy with a T/C value of 0.35 for 50 mg/kg, 0.30 for 100 mg/kg and 0.10 for 200 mg/kg of MI-219 combined with irinotecan, whereas the single agent treatments are less effective (T/C value =0.83 for 50 mg/kg, 0.72 for 100 mg/kg, and 0.52 for 200 mg/kg of MI-219 alone, and 0.54 for irinotecan alone) (P
GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma
Authors: Lovat, Oliverio, Ranalli, Corazzari, Rodolfo, Bernassola, Aughton, Maccarrone, Campbell-Hewson, Pearson, Melino, Piacentini, Redfern
Journal: Cancer Research (2002)
Monophasic action potentials at discontinuation of cardiopulmonary bypass: evidence for contraction-excitation feedback in man.
Authors: PTaggart, P MSutton, TTreasure, MLab, WO'Brien, MRunnalls, R HSwanton, R WEmanuel
Journal: Circulation (1988)

Mechanical dysfunction is the strongest predictor of sudden cardiac death due to arrhythmia. Contraction-excitation feedback whereby changes in myocardial length/tension influence the time course of repolarization and excitability would provide a possible mechanism. Such a relationship has been shown in animals but has yet to be demonstrated in man. A useful model for studying this relationship is provided by the process of weaning off cardiopulmonary bypass after routine coronary artery surgery. During this weaning period of approximately 1 min, the heart is converted from being partially empty and flaccid (i.e., a nonworking state) to being filled and stretched to support the circulation (i.e., a working state). Monophasic action potentials (MAPs) were recorded from the left ventricular epicardium as a measure of repolarization time in 16 patients at discontinuation of cardiopulmonary bypass. Systolic pressure was recorded from the radial artery line. Measurements were made at three stages that rela...
Prevalence and characteristics of disproportionate ventricular septal thickening in patients with coronary artery disease.
Authors: B JMaron, D DSavage, C EClark, W LHenry, ZVlodaver, J EEdwards, S EEpstein
Journal: Circulation (1978)

Echocardiographic or necropsy studies were performed in 151 patients with coronary artery disease. Prevalence of disproportionate septal thickening (septal to free wall ratio greater than or equal to 1.3) was 11%. An abnormally increased septal-free wall ratio in these patients had two principal etiologies. First, it was a manifestation of genetically transmitted hypertrophic cardiomyopathy, as evidenced by disproportionate septal thickening in first degree relatives. Second, it was due to disproportionate septal thickening which did not appear to be a manifestation of genetically transmitted hypertrophic cardiomyopathy. This latter conclusion was suggested by negative echocardiographic studies in some families of patients with both coronary artery disease and disproportionate septal thickening. In addition, numerous disorganized cardiac muscle cells, characteristically present in patients with genetically transmitted hypertrophic cardiomyopathy, were absent from the septum of all patients with disproport...
Direct vasoconstriction and endothelium-dependent vasodilation. Mechanisms of acetylcholine effects on coronary flow and arterial diameter in patients with nonstenotic coronary arteries.
Authors: J MHodgson, J JMarshall
Journal: Circulation (1989)

An endothelium-dependent vasodilator response to acetylcholine has been described recently in patients with coronary artery disease. Those studies determined responses only of large epicardial arteries. Our study was designed to determine the integrated effects of acetylcholine on epicardial diameter, coronary flow, and vascular resistance. Patients (n = 64) with nonstenotic epicardial coronaries underwent coronary angiography with simultaneous recording of coronary flow velocity using a 3F subselective Doppler catheter. Measurements of epicardial arterial cross-sectional area (ECA), velocity, estimated flow (velocity times area), and vascular resistance were made before and after bolus administration of acetylcholine (100 micrograms i.c.). Similar measurements were made after papaverine (12-15 mg i.c.), a nonendothelium-dependent vasodilator. Acetylcholine resulted in a reduction of ECA of 19 +/- 3%, whereas papaverine increased ECA by 9 +/- 2%. Estimated flow increased 69 +/- 12% after acetylcholine and...
100MO Olaparib maintenance vs placebo in platinum-sensitive non-small cell lung cancer: The phase II randomized PIPSeN trial
Authors: S. Postel-Vinay, D. Planchard, M. Antigny, J. Coves Sarto, M. Domine Gomez, R. de las Penas Bataller, M.A. Sala Gonzalez, S. Viteri, J. Pozas Pérez, M. Texier, A.L. Ortega Granados, M.T. Moran Bueno, C.J. Camps, A. Lopez-Martin, M. Provencio, A. Gazzah, J-C. Soria, B. Besse, B. Massuti Sureda, R. Rosell
Journal: Journal of Thoracic Oncology (2021)
Differences between proximal left and right bundle branch block action potential durations and refractoriness in the dog heart.
Authors: J CBailey, D ALathrop, D LPippenger
Journal: Circulation Research (1977)

To date the electrophysiological mechanism responsible for aberrant intraventricular conduction of critically timed premature supraventricular impulses has not been documented. Microelectrode techniques were used to measure in vitro action potential and refractory period durations of the canine proximal right and left bundle branches equidistant from the distal bundle of His. Both measurements in the right bundle branch were statistically significantly longer than these parameters of the left bundle branch. Transection of the bundle branches immediately distal to the distalmost recording sites effected no change in the proximal right bundle action potential but caused marked prolongation of proximal left bundle branch action potential and refractory period durations. We conclude that functional right bundle branch aberrancy is most likely due to the longer proximal right bundle action potential duration and refractoriness. Our data also suggest that the shorter proximal left bundle branch action potential...
Persistence of viral genome into late stages of murine myocarditis detected by polymerase chain reaction.
Authors: LWee, PLiu, LPenn, J WButany, P RMcLaughlin, M JSole, C CLiew
Journal: Circulation (1992)

BACKGROUNDEnteroviruses have been considered as the most common etiologic agents in clinical myocarditis and dilated cardiomyopathy; however, their pathogenetic role remains unknown. Hence, the relation of viral replication and development of cardiomyopathy has been determined in a murine model of myocarditis by evaluating the persistence of viral genome during acute and chronic stages of myocarditis by means of Northern blot hybridization and polymerase chain reaction (PCR).METHODS AND RESULTSDBA/2 mice (n = 146) were injected peritoneally with 10 plaque-forming units of encephalomyocarditis (EMC) virus, and the control mice (n = 33) were injected with normal saline. Animals were randomly killed at 4, 7, 10, 14, 21, 28, 35, and 42 days after infection. Histology revealed acute myocardial necrosis with massive inflammatory cell infiltrate peaking on day 14 followed by increasing fibrosis and declining chronic inflammation features compatible with dilated cardiomyopathy between days 21 and 42. Northern blo...
Measurement of endothelial cytosolic calcium concentration and nitric oxide production reveals discrete mechanisms of endothelium-dependent pulmonary vasodilatation.
Authors: S LArcher, N JCowan
Journal: Circulation Research (1991)

Nitric oxide is an endothelium-derived relaxing factor. Conversion of L-arginine to nitric oxide follows mediator-induced elevation of endothelial cytosolic calcium concentration. However, not all endothelium-dependent vasodilatation is caused by endothelium-derived relaxing factor, and few studies have correlated changes in vascular tone with measurement of free cytosolic calcium concentration or nitric oxide. The effects of three endothelium-dependent vasodilators (acetylcholine, bradykinin, and A23187) on vascular tone and nitric oxide production were studied in proximal rat pulmonary artery rings. Changes in free cytosolic calcium concentration and nitric oxide production were also studied in bovine pulmonary artery endothelial cells. A23187 and bradykinin caused pulmonary vasodilatation, nitric oxide production, and elevation of endothelial calcium concentrations. Although acetylcholine caused endothelium-dependent vasodilatation, it reduced free cytosolic calcium concentration and failed to increase...