tbuckley/cabot-search huggingface dataset:
A Modified Treatment Of Bubonic Plague
Authors: H. M. Rozendaal
Journal: JAMA (1968)

<h3>To the Editor:—</h3> The treatment of plague during recent years has been fairly satisfactory. In general, a combination of streptomycin and a sulfonamide is used and in South Vietnam, where the disease is seen in increasing numbers, this treatment has been recommended by the Ministry of Health during the past five years. It is extremely important that the treatment be started in the very early stages of the disease in order to combat the initial bacteremia and associated toxemia. At the provincial hospital in Nha Trang, South Vietnam, patients with plague began to be admitted to the ward for infectious diseases in October 1967 in increasing numbers and increasing severity. The clinical diagnosis in many cases was confirmed by the demonstration of<i>Pasteurella pestis</i>in material obtained by aspiration from enlarged lymph glands. No cases of the pneumonic form of the disease were seen. Immediately after admission to the hospital,
Efgartigimod: First Approval
Authors: Young-A Heo
Journal: Drugs (2022)

Efgartigimod (efgartigimod alfa-fcab, Vyvgart™) is a first-in-class neonatal Fc receptor antagonist being developed by argenx for the treatment of autoimmune diseases including myasthenia gravis. In December 2021, intravenous efgartigimod received its first approval in the USA for the treatment of generalized myasthenia gravis in adults who are anti-acetylcholine receptor (AChR) antibody positive. Intravenous efgartigimod has also been evaluated for generalized myasthenia gravis in various other countries, with the agent subsequently approved in Japan in January 2022 for generalized myasthenia gravis patients regardless of antibody status and in preregistration stage in the EU. Several clinical studies of intravenous and subcutaneous formulation of efgartigimod are also being investigated for other autoimmune diseases including bullous pemphigoid, chronic inflammatory demyelinating polyradiculoneuropathy, immune thrombocytopenia, autoimmune myositis and pemphigus. This article summarizes the milestones in the development of efgartigimod leading to this first approval for generalized myasthenia gravis.
Final analysis of a non-interventional study on cabozantinib in patients with advanced renal cell carcinoma after prior checkpoint inhibitor therapy (CaboCHECK).
Authors: Viktor Grünwald, Martin Boegemann, Mohammad-Reza Rafiyan, Guenter Niegisch, Marco Julius Schnabel, Anne Flörcken, Michael Maasberg, Christoph Maintz, Mark-Oliver Zahn, Anke Wortmann, Andreas Hinkel, Jochen Casper, Christopher Darr, Thomas Hilser, Matthias Schulze, Disorn Sookthai, Caroline Schoenherr, Philipp Ivanyi
Journal: Journal of Clinical Oncology (2022)

357 Background: Data for cabozantinib after IO-combinations in metastatic renal cell carcinoma (mRCC) remain scarce. We therefore evaluated safety and effectiveness of cabozantinib after failure of IO-based therapies. Methods: Data from patients (pts) with mRCC and cabozantinib treatment after IO-based therapy was retrospectively collected from medical records. Primary endpoint was the incidence of serious adverse events (SAEs). Response rate was assessed clinically (CRR) and/or according to RECIST 1.1. Overall Survival (OS) and Progression Free Survival (PFS) were assessed from start of therapy and data were compared for pts with starting dose of 60 mg (cohort A) vs &lt; 60 mg (cohort B) in a post-hoc analysis. Descriptive statistics and KM-plots were utilized, where appropriate. Results: This final analysis (cut off 08-Oct-21) assessed 56 eligible pts (71.4% male) with median age of 66 yrs. 87.5% (n = 49) had previous nephrectomy. 66.1% (n = 37) had clear cell RCC. 89.3% (n = 50) had ≥2 previous lines. ECOG ≤1 was 33.9% (n = 19). IMDC factors were 0 in 2 (3.6%), ≥1 in 21 (37.5%), missing in 31 pts (55.4%). 62.5% (n = 35) started at reduced dose. 55.4% (n = 31) required dose reductions and 1.8% (n = 1) discontinuation. Median treatment duration was 6.1 months (m). PR was 10.7% (n = 6), SD 19.6% (n = 11), PD 12.5% (n = 7) and missing in 57.1% (n = 32). Median OS and PFS were 15.34 m (95% CI 8.94, 20.93) and 6.34 m (95% CI 5.29, 8.25) in the ITT, 10.48 m (95% CI 6.01, 34.14) and 6.51 m (95% CI 2.99, 10.87) in cohort A and 16.46 m (95% CI 9.56, 23.33) and 6.34 m (95% CI 4.86, 8.71) in cohort B, respectively. All grade AEs and grade 3-5 AEs were 87.5% (n = 49) and 44.6% (n = 25) in the ITT, 95.0% (n = 19) and 55.0% (n = 11) in cohort A and 85.7% (n = 30) and 40.0% (n = 14) in cohort B. SAEs were reported in 21.4% (n = 12) of pts, which were 30.0% (n = 6) of cohort A and 17.1% (n = 6) of cohort B. Treatment related SAEs were reported in 10.7% (n = 6) of pts, which were 15.0% (n = 3) in cohort A and 8.6% (n = 3) in cohort B. Conclusions: Cabozantinib directly after IO therapy was safe and feasible. No new safety signals were reported. A reduced starting dose was frequently utilized and was not associated with adverse outcomes. Our data supports the use of cabozantinib after IO-failure. Major limitation was the retrospective nature of our study.[Table: see text]
The new Medical Schools and curriculum innovation
Authors: E. F. Rosinski
Journal: JAMA (1971)

When the federal government made its commitment to support medical school construction and education almost nine years ago, many educators looked toward the schools that would be created as places where educational innovation would be accepted as a way of life. As of July 1970, a total of 11 of these new medical schools had become operational, ie, they admitted their first class of students. Yet the question remains: How innovative have these schools been? Few data are available but a review of schools' curricula is discouraging. "Innovative," "exciting," "progressive," "relevant," and "meaningful" are words used to describe the curriculum and courses of study. It would appear that the new schools are truly centers of innovation in education. But to anyone familiar with medical education, the curricula of these schools look like either the traditional basic-clinical science approach taught by discipline, or a variation of the curriculum pioneered by Case
MATERNAL IMPRESSIONS.
Authors: WM. F. BATMAN
Journal: JAMA (1896)

The definition of maternal impressions is that a profound and sudden impression made on the mother's mind may pervert or stop the growth, or cause defect in the child with which she is pregnant. Maternal influences over the young have been recognized from the earliest history of man. The thirtieth chapter of Genesis gives Jacob's policy whereby he became rich. He pilled the rods of green poplar, hazel and chestnut and set them before Laban's herd and by maternal impressions he colored enough of the herd in ten or a dozen years to become rich. And the next chapter tells us of Rachel's influence over Joseph and Benjamin to impress the race of mankind. While this force has been recognized among all nations of people, it is only in the last few years that an attempt has been made to separate the truisms from the superstitions on this subject. In
Palindromic Rheumatism
Authors: A. Wingfield
Journal: BMJ (1945)

Palindromic RheumatismThis syndrome was described by Hench and Rosenberg (1941) on the basis of their findings in 34 cases; of these 19 were males and 15 females.They recorded multiple afebrile attacks of acute arthritis, peri-arthritis, and sometimes also para- arthritis with pain, swelling, redness, and disability.The attacks appeared suddenly, developed rapidly, and lasted for a few hours up to about 24, and recurred at short or long -irregularly spaced intervals.The blood sedimentation rate was normal between attacks, but rose to an average of 24 on the uncorrected Westergren scale.The history in these patients extended over periods varying from 1 to 25 years, with from 2 up to 250 attacks a year.The attacks lasted from 3 hours to 6 days, and successive attacks affected different joints.The authors recognized the similarity to the angio-neural arthrosis described by Solis-Cohen (1911, 1913, 1914) and to the allergic arthritis described by Kahlmeter (1939), but the syndromes reported by the latter authors show certain fundamental differ- ences from that of Hench and Rosenberg.Intermittent iydrarthrosis, excellently described by Garrod .(1907), also differs from palindromic rheumatism in that the attacks gener- ally recur in the same joint and at mathematically regular intervals.Cain (1944) recorded a single case apparently con- forming exactly to the picture of palindromic rheumatism.No other case reports appear to have been published.The following case seems to conform to the typical description:A Port official was admitted to the Seamen's Hospital on Sept. 1, 1943.He gave a history of ffitting pains in the joints, first noticed in 1930 after he had fallen into the river.The joints became painful and repeatedly swollen, and the disability lasted from 1 to 2 days at
Data Do Not Support Selection by Target Perfusion Mismatch of Patients for Endovascular Stroke Treatment Within the 16- to 24-Hour Interval—Reply
Authors: Gregory W. Albers, Scott Brown, Raul G. Nogueira
Journal: JAMA Neurology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Reclassification of Severe Ischemia on PET Versus SPECT MPI Using a Same-Patient Simultaneous Imaging Protocol
Authors: Femina S. Patel, Timothy M. Bateman, John A. Spertus, A. Iain McGhie, Staci A. Courter, James A. Case, Gary V. Heller, Krishna K. Patel
Journal: JACC. Cardiovascular imaging (2022)
The Diagnosis of Pancreatic Disease.
Journal: JAMA (1927)

This monograph, the original title of which was "The Value of the Various Methods of Investigating Diseases of the Pancreas," was the 1926 Rogers prize essay in the University of London. Following a brief historical introduction, the author takes up first in a clear and concise manner the anatomic, physiologic and pathologic background of diseases of the pancreas. The clinical aspects are then discussed, with due emphasis on the importance of history and physical diagnosis. As might be expected from the original title, about half the book is taken up with description and evaluation of the many tests that have been used in attempting to detect changes in pancreatic function; tests on duodenal contents, for pancreatic ferment in the stomach, in the feces or in the urine; indirect tests based on study of undigested food in the feces, on materials inclosed in enteric capsules or activated by pancreatic juice; tests
Cell motion predicts human epidermal stemness
Authors: Daisuke Nanba, Fujio Toki, Sota Tate, Matome Imai, Natsuki Matsushita, Ken Shiraishi, Koji Sayama, Hiroshi Toki, Shigeki Higashiyama, Yann Barrandon
Journal: The Journal of Experimental Medicine (2015)

ResultsRotational speed of keratinocytes in the two-cell colony stage is associated with their proliferative capacity
Woolsorters' Disease
Authors: S. Lodge
Journal: BMJ (1881)

THE BRITISH MfEDICAL _OURNAL.Uune II, i88I.of which was covered with a dirty grey-coloured eschar.Serum from vesicles contained a few bacilli; half a drop, given to a rabbit, had no perceptible effect.9 P.M.He had no pain or distress.The tongue was moist.He had taken food moderately.The swelling ha(l extended over the scapula; as far as the middle, it was hard, terminating by a distinct ridge; beyond, it was softer.In front, the swelling bad extended over the chest, and was not so hard as behind.Pulse I I6, soft.After he had been helped up in bed to the sitting position, and lay down again, the pulse was 130, and irregular.Temperature in the left axilla 99.80, in the rectum xo4.i.; respiration 24.May 24tb, 10.30 A.M.He passed a fairly good night; was not rest- less.He had no pain, but some uneasiness over the abdomen, which was relieved by vomiting.He appeared calm and composed.Pulse 130, very small, and difficult to count.Temperature in the left axilla 99.1, in the right axilla 99.8°, in the rectum I02.3'; respiration 22. Serum from vesicles contained ten to twenty bacilli in each field.The contents of two tubes, given to a mouse, were fatal in seventeen and a half hours.9.30 P.M.He had a restless day; passed no urine; his appetite was gone; his face shrunken.The swelling was extending; the extremities were cold; pulse imperceptible; temperature under the tongue 950.He died ten hours afterwards.Serum from the arm con- tained bacilli; two tubes, given to a mouse forty-five hours afterwards, were fatal in sixty-five hours.Post mortemn examination, made by Mr. Kenyon, nine hours after
Abstract 359: Use of Resuscitative Balloon Occlusion of the Aorta in a Swine Model of Prolonged Cardiac Arrest
Authors: Mohamad H Tiba, Brendan M McCracken, Brandon C Cummings, Carmen I Colmenero, Chandler J Rygalski, Cindy H Hsu, Thomas H Sanderson, Brahmajee K Nallamothu, Robert W Neumar, Kevin R Ward
Journal: Circulation (2018)

Introduction: Despite advancements in CPR, survival to hospital discharge remains low for in- and out-of-hospital cardiac arrest (CA). Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) is an evolving tool for temporary control of non-compressible truncal hemorrhage. In this investigation, we examined whether REBOA use during non-traumatic CA would produce favorable hemodynamic changes associated with return of spontaneous circulation (ROSC). Hypothesis: We hypothesized that REBOA use during CPR would result in higher coronary perfusion pressure (CPP) and common carotid artery blood flow (C-Flow) in a prolonged model of CA. Methods: Six male swine were anesthetized and instrumented to measure and monitor CPP, and C-Flow. A REBOA catheter (Prytime Medical Devices) was advanced into zone 1 of the aorta through the femoral artery. Ventricular fibrillation was electrically induced and untreated for 8 minutes. CPR was started manually at minute-8, then changed to mechanical CPR at minute-12 for the duration of the experiment. Continuous infusion of epinephrine (0.0024mg/kg/min) was simultaneously started with mechanical CPR. The REBOA balloon was inflated beginning at minute-16 for 3 minutes then deflated for 3 minutes for a total of 6 cycles. At the end of the final cycle (REBOA inflation), CPR was stopped (after 33 minutes of total arrest time) and animals were defibrillated using 200 J biphasic shocks, repeated up to 6 times. Animals achieving ROSC were monitored for an additional 25 minutes. Results: Analysis using repeated measure ANOVA showed significant differences between balloon deflation and inflation periods for CPP (p&lt;0.0001) with mean difference(SD) of 14(2.6) (Range: 17 to 42) mmHg and for C-Flow (p&lt;0.0001) with mean difference(SD) 16(23) (Range: 115 to 269) mL/min across all animals. Three animals achieved ROSC and had significantly higher CPP (48 vs. 24mmHg, p&lt;0.0001) and C-Flow (249 vs. 168mL/min) by t-test (p&lt;0.0001). Post-mortem aortic histology did not reveal any changes produced by balloon inflation. Conclusion: REBOA significantly increased CPP and C-Flow in this swine model of prolonged CA. These increases may have contributed to the ability to achieve ROSC after greater than 30 min of CA.
Abstract 17376: Risk of Early Reablation Post Cryoballoon Ablation
Authors: Emrie Tomaiko, Adnan Habib, Geoffrey J Orme, Wilber Su
Journal: Circulation (2018)

Introduction: Post-ablation radiofrequency tissue friability has been described; however, tissue friability post cryoablation has not been well studied. We report a case of left atrial perforation with normal contact force radiofrequency ablation 22 days after initial cryoballoon ablation. Description: A 59-year-old male with persistent atrial fibrillation, severe biatrial enlargement, non-ischemic cardiomyopathy (EF of 20%), underwent initial cryoballoon pulmonary vein isolation with left atrial roof cryoablation with restoration of sinus rhythm and no complications. Patient presented 22 days later with sustained atrial flutter and heart rate over 130 bpm refractory to aggressive medical management, cardioversion, and acute on chronic congestive heart failure. Early re-ablation was performed with electrophysiology study and 3D activation map confirming ectopic atrial tachycardia foci arising from left atrial roof, anterior to the border of previously cryo-ablated region. St. Jude TactiCath™ contact force ablation catheter, was used to ablate this foci, and termination within 5 seconds of ablation was observed. Using the Force-Time Integral index to guide further ablation, the surrounding area was ablated for an additional 20 seconds at 30 W with a maximum recorded contact force throughout the procedure of 35 grams, and an average of 10-15 grams.A decrease in systolic blood pressure from 120 mmHg to 80 mmHg was noted, and intracardiac ultrasound confirmed 1.5 cm of pericardial effusion. Successful pericardiocentesis and reversal of anticoagulation was performed with ongoing bleeding, and eventual surgical intervention was required. On direct visualization during surgery, the left atrial roof perforation was confirmed, and was noted to be very friable and difficult to retain suture for repair. Patient did well post-operatively and was discharged with no recurrence of arrhythmias. Conclusions: Despite standard of care monitoring, including force-time integral index and contact-sensing catheters, atrial perforation occurred likely due to increased tissue friability post initial cryoablation. The optimal timing for repeat ablation is not completely understood, and extreme caution and avoidance of early re-ablation risk is prudent.
Bariatric Surgery Approaches Reduce Fatty Liver Disease
Authors: Anita Slomski
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antidepressant Drugs
Authors: D. E. Seymour
Journal: BMJ (1964)

MEDIBCLJOURNALto Clostridium welchii infection complicating induction of labour, in the presence of a dead foetus, with hypertonic glucose.We wish to report a similar case.Mrs. A. B. aged 41, gravida 12, 35 weeks pregnant, was admitted to the National Maternity Hospital because of intrauterine death of the foetus of some days' duration.Death appeared to be due to pre-eclamptic toxaemia superimposed on essential hypertension.Three days later 130 ml. of liquor amnii were replaced by 200 ml. of 50% glucose solution by transabdominal amniotomy.The patient suffered no discomfort until 16 hours later, when she was awakened by urgent respiratory distress.The clinical diagnosis was one of obvious pulmonary embolism.She died in seven hours.At post-mortem examination the uterus was found to be ballooned by gas.The heart and great veins contained frothy blood.The placenta presented a honeycombed appearance consistent with the presence of multiple bubbles of gas.Cl. welchie was recovered from the amniotic fluid.A method of treatment which introduces 100 g. of glucose into a body cavity occupied by a corpse produces an environment highly favourable to the explosive proliferation of saccharolytic organisms, and the consequent production of large quantities of gas.We report this tragedy as a matter of urgency so that it may be seen that this method of inducing labour is fraught with grave danger.
Human Care
Authors: C. P. Snow
Journal: JAMA (1973)

Years ago, I had to pay regular visits to a friend in a hospital. She was a young woman of about 30 when she was first afflicted, or when the symptoms became manifest. She was clever, good-looking in a delicate fashion, and unusually kind. So far as it is possible for a human being, she was entirely benevolent. The disease that struck her was what was then called disseminated sclerosis, though nowadays the fashionable term seems to be multiple sclerosis. It followed a classical course, with remissions in the early phases, during which she could carry on with her job. Total paralysis came more quickly than was expected. Sometime before the end, the most she could do in the way of movement was to touch a bedside bellpush. She couldn't light a cigarette for herself, or put it to her lips. Her speech was almost unaffected. Many of you will