tbuckley/cabot-search huggingface dataset:
Abstract 41: Early Post-Resuscitation Levels of Cytochrome- <i>c</i> and Interleukin-6 after Prolonged Porcine Cardiac Arrest
Authors: David D Salcido, Eric S Logue, Brian P Suffoletto, Jon C Rittenberger, James J Menegazzi
Journal: Circulation (2007)

Background: The identification of serum biomarkers of ischemic injury could provide a means of assessing interventions designed to limit reperfusion injury after return of spontaneous circulation (ROSC). We sought to characterize the early post-ROSC timecourse of two candidate biomarkers of ischemic injury (cytochrome- c and IL-6) in a swine model of ventricular fibrillation (VF). We hypothesized that these two biomarkers would be elevated immediately after ROSC. Methods: Twenty-five mixed breed domestic swine were anesthetized and instrumented with ECG, temperature probe, and aortic and right atrial pressure transducers. VF was induced with a transthoracic shock and untreated for 8 minutes. Then mechanical CPR was done for 2 minutes, before drugs were given (epinephrine, vasopressin, and propranolol) with 3 additional minutes of CPR (first defibrillation attempt at 13 minutes of VF). Blood samples were drawn at the end of instrumentation (i.e. just prior to VF), and at 20, 40, and 60 minutes after ROSC. Samples were centrifuged and serum extracted. Cytochrome- c was analyzed via Western immunoblotting. IL-6 was analyzed with ELISA. Results: No cytochrome- c was detected in any animal, at any timepoint through 60 min. IL-6 was similar to baseline levels through 40 min, but was 121% of baseline at 60. Conclusions: Neither biomarker was elevated immediately after ROSC. Mitochondrial damage (as indicated by the absence of cytochrome- c ) may be delayed by as much as an hour after ROSC, hinting at a possible therapeutic window for interventions like hypothermia. Likewise, inflammatory cascades (as indicated by IL-6) may not begin immediately post-ROSC, but might by one hour.
Obstetric and Gynecologic Nursing.
Journal: JAMA (1913)

When a book of this character has gone to four editions in twelve years, little need be said regarding its worth. The book has been thoroughly revised and enlarged by Dr. Davis. It is printed in large, clear type and the illustrations are, as a rule, admirable. Some of them, however, show the effects of wear through use in various editions. While the subject matter is excellent and up-to-date and the type large and clear, the book is printed on such heavy paper that its bulk and weight are almost oppressive, and it would seem that this defect should be remedied in subsequent editions.
Racial Disparities in Recurrence and Overall Survival in Patients With Locoregional Colorectal Cancer
Authors: Rebecca A Snyder, Chung-Yuan Hu, Syed Nabeel Zafar, Amanda Francescatti, George J Chang
Journal: JNCI Journal of the National Cancer Institute (2020)

Abstract Background The purpose of this study was to determine the association between race and long-term cancer outcomes (recurrence and overall survival) within a population of US patients with locoregional colorectal cancer (CRC). Methods A cohort study of primary patient data merged with the National Cancer Database as part of a Commission on Cancer Special Study was performed. The study population was a random sample of patients undergoing surgery for stage I to III CRC between years 2006 and 2007 with 5 years of follow-up. Propensity-weighted multivariable Cox regression was performed with pooled results to yield statistical inferences. Prespecified sensitivity analysis was performed only for patients who received guideline concordant care (GCC) of primary CRC. All statistical tests were 2-sided. Results The study population included 8176 patients, 9.9% (n = 811) Black and 90.1% (n = 7365) White. Black patients were more likely to be uninsured or underinsured, have lower household income, and lower educational status (all P &amp;lt; .001). Rates of GCC were higher among Black vs White patients with colon cancer (76.9% vs 72.6%, P = .02), and Black and White patients with rectal cancer were treated with radiation at similar rates (69.1% vs 66.6%, P = .64). Black race was independently associated with increased risk of recurrence (hazard ratio [HR] = 1.48, 95% confidence interval [CI] = 1.26 to 1.73) and mortality (HR = 1.37, 95% CI = 1.18 to 1.59). In sensitivity analysis of only patients who received GCC, observed effects for recurrence (HR = 1.51, 95% CI = 1.27 to 1.79) and overall survival (HR = 1.40, 95% CI = 1.18 to 1.66) persisted. Conclusions Despite higher rates of GCC for CRC, Black patients experience a higher risk of recurrence and mortality compared with White patients.
Fetal cardiac dysfunction in intrahepatic cholestasis of pregnancy is associated with elevated serum bile acid concentrations
Authors: Tharni Vasavan, Sahil Deepak, Indu Asanka Jayawardane, Maristella Lucchini, Catherine Martin, Victoria Geenes, Joel Yang, Anita Lövgren-Sandblom, Paul Townsend Seed, Jenny Chambers, Sophia Stone, Lesia Kurlak, Peter Hendy Dixon, Hanns-Ulrich Marschall, Julia Gorelik, Lucy Chappell, Pam Loughna, Jim Thornton, Fiona Broughton Pipkin, Barrie Hayes-Gill, William Paul Fifer, Catherine Williamson
Journal: Journal of Hepatology (2020)

Intrahepatic cholestasis of pregnancy (ICP) is associated with an increased risk of stillbirth. This study aimed to assess the relationship between bile acid concentrations and fetal cardiac dysfunction in patients with ICP who were or were not treated with ursodeoxycholic acid (UDCA).Bile acid profiles and NT-proBNP, a marker of ventricular dysfunction, were assayed in umbilical venous serum from 15 controls and 76 ICP cases (36 untreated, 40 UDCA-treated). Fetal electrocardiogram traces were obtained from 43 controls and 48 ICP cases (26 untreated, 22 UDCA-treated). PR interval length and heart rate variability (HRV) parameters were measured in 2 behavioral states (quiet and active sleep).In untreated ICP, fetal total serum bile acid (TSBA) concentrations (r = 0.49, p = 0.019), hydrophobicity index (r = 0.20, p = 0.039), glycocholate concentrations (r = 0.56, p = 0.007) and taurocholate concentrations (r = 0.44, p = 0.039) positively correlated with fetal NT-proBNP. Maternal TSBA (r = 0.40, p = 0.026) and alanine aminotransferase (r = 0.40, p = 0.046) also positively correlated with fetal NT-proBNP. There were no significant correlations between maternal or fetal serum bile acid concentrations and fetal HRV parameters or NT-proBNP concentrations in the UDCA-treated cohort. Fetal PR interval length positively correlated with maternal TSBA in untreated (r = 0.46, p = 0.027) and UDCA-treated ICP (r = 0.54, p = 0.026). Measures of HRV in active sleep and quiet sleep were significantly higher in untreated ICP cases than controls. HRV values in UDCA-treated cases did not differ from controls.Elevated fetal and maternal serum bile acid concentrations in untreated ICP are associated with an abnormal fetal cardiac phenotype characterized by increased NT-proBNP concentration, PR interval length and HRV. UDCA treatment partially attenuates this phenotype.The risk of stillbirth in intrahepatic cholestasis of pregnancy (ICP) is linked to the level of bile acids in the mother which are thought to disrupt the baby's heart rhythm. We found that babies of women with untreated ICP have abnormally functioning hearts compared to those without ICP, and the degree of abnormality is closely linked to the level of harmful bile acids in the mother and baby's blood. Babies of women with ICP who received treatment with the drug UDCA do not have the same level of abnormality in their hearts, suggesting that UDCA could be a beneficial treatment in some ICP cases, although further clinical trials are needed to confirm this.
Prediction of Kidney Drug Clearance: A Comparison of Tubular Secretory Clearance and Glomerular Filtration Rate
Authors: Yan Chen, Leila R. Zelnick, Andrew N. Hoofnagle, Catherine K. Yeung, Laura M. Shireman, Brian Phillips, Calder C. Brauchla, Ian de Boer, Linda Manahan, Susan R. Heckbert, Jonathan Himmelfarb, Bryan R. Kestenbaum
Journal: Journal of the American Society of Nephrology (2020)

Background Although proximal tubular secretion is the primary mechanism of kidney drug elimination, current kidney drug dosing strategies are on the basis of eGFR. Methods In a dedicated pharmacokinetic study to compare GFR with tubular secretory clearance for predicting kidney drug elimination, we evaluated stable outpatients with eGFRs ranging from 21 to 140 ml/min per 1.73 m 2 . After administering single doses of furosemide and famciclovir (metabolized to penciclovir), we calculated their kidney clearances on the basis of sequential plasma and timed urine measurements. Concomitantly, we quantified eight endogenous secretory solutes in plasma and urine using liquid chromatography-tandem mass spectrometry and measured GFR by iohexol clearance (iGFR). We computed a summary secretion score as the scaled average of the secretory solute clearances. Results Median iGFR of the 54 participants was 73 ml/min per 1.73 m 2 . The kidney furosemide clearance correlated with iGFR ( r =0.84) and the summary secretion score ( r =0.86). The mean proportionate error (MPE) between iGFR-predicted and measured furosemide clearance was 30.0%. The lowest MPE was observed for the summary secretion score (24.1%); MPEs for individual secretory solutes ranged from 27.3% to 48.0%. These predictive errors were statistically indistinguishable. Penciclovir kidney clearance was correlated with iGFR ( r =0.83) and with the summary secretion score ( r =0.91), with similar predictive accuracy of iGFR and secretory clearances. Combining iGFR with the summary secretion score yielded only modest improvements in the prediction of the kidney clearance of furosemide and penciclovir. Conclusions Secretory solute clearance measurements can predict kidney drug clearances. However, tight linkage between GFR and proximal tubular secretory clearance in stable outpatients provides some reassurance that GFR, even when estimated, is a useful surrogate for predicting secretory drug clearances in such patients.
200O Pembrolizumab plus axitinib (pembro + axi) vs sunitinib in metastatic renal cell carcinoma (mRCC) outcomes of the KEYNOTE-426 study in patients from eastern Asia
Authors: C.N. Kondoh, W.K. Bae, S. Tamada, N. Matsubara, H.J. Lee, R. Mizuno, S. Ani, G. Kimura, Y. Tomita, C-H. Chang, J.W-C. Chang, J. Lin, R. Perini, L.R. Molife, T.B. Powles, B. Rini, H-J. Chung
Journal: Annals of Oncology (2020)
Abnormal Calcium Homeostasis: One Mechanism in Diastolic Heart Failure⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Authors: Michael R. Zile, William H. Gaasch
Journal: Journal of the American College of Cardiology (2011)
Association of Cumulative Paternal Early Life Stress With White Matter Maturation in Newborns
Authors: Hasse Karlsson, Harri Merisaari, Linnea Karlsson, Noora M. Scheinin, Riitta Parkkola, Jani Saunavaara, Tuire Lähdesmäki, Satu J. Lehtola, Maria Keskinen, Juho Pelto, John D. Lewis, Jetro J. Tuulari
Journal: JAMA Network Open (2020)

<h3>Importance</h3> Early life stress (ELS) has been shown to affect brain development and health outcomes. Recent animal studies have linked paternal early stress exposures with next-generation outcomes. Epigenetic inheritance through the male germline has been suggested to be one of the mechanisms. <h3>Objectives</h3> To test whether paternal ELS, as measured using the Trauma and Distress Scale, is associated with neonate brain development. <h3>Design, Setting, and Participants</h3> This cohort study included data from participants from the prospective 2-generation FinnBrain Birth Cohort, which was collected from 2011 to 2015. Pregnant women and the fathers were consecutively recruited at gestational week 12 from maternity clinics in Finland. Magnetic resonance imaging data were analyzed in 2019. Participants in this study were 72 families (infant, father, mother). <h3>Exposure</h3> Paternal exposure to ELS. <h3>Main Outcomes and Measures</h3> Fractional anisotropy (FA) values in the major white-matter tracts of the newborn brain. <h3>Results</h3> A total of 72 trios (infant, mother, and father) were analyzed. At the time of delivery, the mean (SD) age was 31.0 (4.4) years for fathers and 30.3 (4.5) years for mothers. Forty-one infants (57%) were boys; mean (SD) child age at inclusion was 26.9 (7.2) days from birth and 205 (8) days from estimated conception. Increasing levels of paternal ELS were associated with higher FA values in the newborn brain in the body of the corpus callosum, right superior corona radiata, and retrolenticular parts of the internal capsule. This association persisted after controlling for maternal ELS, maternal socioeconomic status (SES), maternal body mass index, maternal depressive symptoms during pregnancy, child sex, and child age from birth and gestation corrected age when imaged. In additional region-of-interest analyses, the association between FA values and paternal Trauma and Distress Scale sum scores remained statistically significant in the earliest maturing regions of the brain, eg, the genu of the corpus callosum (in the regression models, β = 0.00096; 95% CI, 0.00034-0.00158;<i>P</i> = .003) and the splenium (β = 0.00090; 95% CI, 0.00000-0.00180;<i>P</i> = .049). <h3>Conclusions and Relevance</h3> This cohort study found a statistically significant association between paternal ELS and offspring brain development. This finding may have far-reaching implications in pediatrics, as it suggests the possibility of a novel route of intergenerational inheritance of ELS on next-generation brain development.
FDA Oncology Center of Excellence Project Renewal: Engaging the Oncology Community to Update Product Labeling for Older Oncology Drugs
Authors: Paul G. Kluetz, Patricia Keegan, George D. Demetri, Katherine Thornton, Joohee Sul, Janice Kim, Harvey Katzen, Laurie Beth Burke, R. Donald Harvey, Elleni Alebachew, Sundeep Agrawal, Abhilasha Nair, Martha Donoghue, William F. Pierce, Stacy S. Shord, Jennifer J. Gao, Richard Pazdur
Journal: Clinical Cancer Research (2020)

Abstract The FDA conducts independent reviews of scientific data obtained with investigational drug products to ensure that they are safe and effective. As a result of this process, FDA-approved product labeling is generated that is considered one of the most trusted sources of information for use of an approved drug. But FDA approval is only the beginning of the life cycle of a new drug; the first oncology drugs now have more than 7 decades of clinical experience in the postmarketing setting. Due, in part, to lack of incentives, some companies may not seek inclusion of new data, other than new safety information, in FDA-approved product labeling. Ensuring that product labeling provides adequate directions for use is important for all drugs, including older therapies that may form the backbone of many standard combination regimens for pediatric and adult cancers. Project Renewal is an FDA Oncology Center of Excellence pilot program that leverages expertise from the clinical and scientific oncology communities to review published literature and generate a drug-specific product report summarizing data that may support updates to FDA-approved product labeling. This article provides a broad overview of Project Renewal's collaborative pilot process for identifying and assessing literature supporting potential labeling updates, while engaging the oncology community to increase awareness of FDA's evidentiary standards and deliberative processes used when considering the addition of new indications and dosing regimens to product labeling.
Anatomy Meets Function: Modeling Coronary Flow Reserve on the Basis of Coronary Computed Tomography Angiography⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Authors: Stephan Achenbach
Journal: Journal of the American College of Cardiology (2011)
154P A multicenter, prospective study of apatinib plus chemotherapy as neoadjuvant treatment for locally advanced gastric cancer
Authors: Y-H. Tang, F-H. Wang, G-J. Lin, J-X. Lin, C-H. Zheng, P. Li, J-W. Xie, J-B. Wang, J. Lu, Q-Y. Chen, L-L. Cao, M. Lin, R-H. Tu, Z-N. Huang, J-L. Lin, H-L. Zheng, C. Huang
Journal: Annals of Oncology (2020)
Metabolomic and transcriptomic analyses of the anti-rheumatoid arthritis potential of xylopic acid in a bioinspired lipoprotein nanoformulation
Authors: Raphael N. Alolga, Yaw Opoku-Damoah, David A. Alagpulinsa, Feng-Qing Huang, Gaoxiang Ma, Maria A.S.C. Chavez Leon, Chifodya Kudzai, Xiaojian Yin, Yang Ding
Journal: Biomaterials (2020)
Post-Dilation of Superficial Femoral Artery Stents With Cryoplasty: Does the COBRA Trial Take a Bite Out of Diabetic Restenosis?⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Authors: Anand Prasad
Journal: Journal of the American College of Cardiology (2012)
12892 A highly corrective cosmetic make-up significantly improves quality of life, as well as dryness and tautness of skin, for subjects with acne, melasma, rosacea, or other facial concerns that would benefit from corrective make-up
Authors: Ana Maria Dumitrescu, Andra Cristea, Anna Suwalska, Delphine Kerob
Journal: Journal of the American Academy of Dermatology (2020)
218MO Comparison of a 22-gene genomic classifier (GC) with NCCN for risk stratification of Asian prostate cancers (PCa)
Authors: W. Wai Yee, A.Y.L. Sim, K.P. Low, A. Meng, J. Tan, J.K.L. Tuan, T.W.K. Tan, M.L.C. Wang, L.S. Lee, K-J. Tay, C.W.S. Cheng, C.S. Tan, L.Y. Khor, J. Yeong, E. Davicioni, M.L.K. Chua
Journal: Annals of Oncology (2020)
Abstract 16184: Outcomes and Care Quality Metrics for Women of Reproductive Age Living With Rheumatic Heart Disease in Uganda
Authors: Andrew Y Chang, Juliet Nabbaale, Emmy Okello, Isaac Ssinabulya, Michele Barry, Andrea Beaton, Allison R Webel, Christopher Longenecker
Journal: Circulation (2019)

Introduction: Rheumatic Heart Disease (RHD) disproportionately affects women of reproductive age, as it increases the risk of complications and death during pregnancy and childbirth. In sub-Saharan...
Antibodies, Immunity, and COVID-19
Authors: Brad Spellberg, Travis B. Nielsen, Arturo Casadevall
Journal: JAMA Internal Medicine (2020)

Kristina L. Bajema, MD, MSc; Ryan E. Wiegand, MS; Kendra Cuffe, MPH; Sadhna V. Patel, MPH; Ronaldo Iachan, PhD; Travis Lim, DrPH; Adam Lee, MS; Davia Moyse, MA; Fiona P. Havers, MD, MHS; Lee Harding, MS; Alicia M. Fry, MD, MPH; Aron J. Hall, DVM, MSPH; Kelly Martin, MPH; Marjorie Biel, MPH; Yangyang Deng, MS; William A. Meyer III, PhD; Mohit Mathur, MD, PhD; Tonja Kyle, MS; Adi V. Gundlapalli, MD, PhD; Natalie J. Thornburg, PhD; Lyle R. Petersen, MD, MPH; Chris Edens, PhD
146P Red cell distribution width and mean corpuscular volume ratio as a promising new marker for chemotherapy effects in remnant gastric cancer: An analysis of a multi-institutional database
Authors: K-X. Xu, Y-X. Gao, L-L. Shen, C-H. Zheng, P. Li, J-W. Xie, J-B. Wang, J-X. Lin, J. Lu, Q-Y. Chen, L-L. Cao, M. Lin, R-H. Tu, Z-N. Huang, J-L. Lin, H-L. Zheng, C. Huang
Journal: Annals of Oncology (2020)
80MO Gut microbiome analysis for predicting neoadjuvant chemoradiotherapy response in locally advanced rectal cancer patients
Authors: Y. Yi, L. Shen, W. Shi, F. Xia, H. Zhang, Y. Wang, J. Zhang, Y. Wang, X. Sun, Z. Zhang, W. Zou, W. Yang, L. Zhang, Y. Ma, Z. Zhang
Journal: Annals of Oncology (2020)
Correspondence on ‘<i>Prevotella copri</i>in individuals at risk for rheumatoid arthritis’
Authors: Tianyue Sun, Jing Ni
Journal: Annals of the Rheumatic Diseases (2020)

We read with great interest the articles by Alpizar-Rodriguez et al 1 with regard to the impact of dysbiosis on the risk of rheumatoid arthritis (RA). Meanwhile, we noticed the opposite conclusions of Mendelian randomisation (MR) research works from Inamo2 and Lee.3 For obtaining a reliable result, we thought some issues were supposed to pay attention to and illustrate clearly in the MR study. To begin with, single nucleotide polymorphisms (SNPs) associated with gut microbiome at the genome-wide significance level (p<5×10−8) should be derived from a genome-wide association study (GWAS) with the largest sample size or a meta-analysis of GWASs, rather than combining SNPs from different GWASs to analyse directly.4 5 Initially, we obtained a total of 41 genetic instrumental variables (IVs) from the results of the gut microbiome GWAS carried out with up to 1812 individuals of European ancestry.6 To avoid the ethnic heterogeneity of genetic associations, the effect size and standard errors for the associations of IVs with RA were extracted from a large RA GWAS, including 14 361 cases and …
15953 Clearance of head involvement in plaque psoriasis with tildrakizumab treatment in the phase 3 reSURFACE 1 study
Authors: Alan M. Menter, George J. Murakawa, Holly Glover, Alan M. Mendelsohn, Jeff Parno, Stephen J. Rozzo, Aditya K. Gupta
Journal: Journal of the American Academy of Dermatology (2020)
17793 Bathing practices in atopic dermatitis: A systematic review and meta-analysis
Authors: Tammy Hua, Muhammad Yousaf, Eran C. Gwillim, Yik Weng Yew, Brad Lee, Kevin Hua, Taylor Erickson, Brian T. Cheng, Jonathan I. Silverberg
Journal: Journal of the American Academy of Dermatology (2020)
Manipulating dynamic tumor vessel permeability to enhance polymeric micelle accumulation
Authors: Yuta Inoue, Yu Matsumoto, Kazuko Toh, Kazuki Miyano, Horacio Cabral, Kazunori Igarashi, Shinichi Iwasaki, Kazunori Kataoka, Tatsuya Yamasoba
Journal: Journal of Controlled Release (2020)
235O Efficacy and safety of niraparib in Chinese patients with platinum-sensitive recurrent ovarian cancer (NORA) with individualized starting dose: A subgroup analysis of a randomized, double-blind, placebo-controlled, phase III trial
Authors: X. Wu, J. Zhu, R. Yin, J. Yang, J. Liu, J. Wang, L. Wu, Z. Liu, Y. Gao, D. Wang, G. Lou, H. Yang, Q. Zhou, B. Kong, Y. Huang, L. Chen, G. Li, R. An, K. Wang, Y. Zhang
Journal: Annals of Oncology (2020)
Exploring the Cardiac Phenotypes of Prematurity—Reply
Authors: Kara N. Goss, Marlowe W. Eldridge
Journal: JAMA Cardiology (2020)

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Endothelin-1 Release and Stimulation of the Inflammatory Cascade: Is Acute Coronary Syndrome Triggered by Watching Spectator Sports?**Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Authors: Karina W. Davidson, Matthew Burg, Daichi Shimbo
Journal: Journal of the American College of Cardiology (2010)