tbuckley/cabot-search huggingface dataset:
Abstract 9346: Results of a Randomized Study to Understand the Patient Experience of Pain and Satisfaction During Cardiac Catheterization Using an Interval of Time
Authors: Anna E Mall, Thomas A Girton, Kevin Yardley, Elinore Simpson, Meghan Ronn, Paige Rossman, Tiffany McEwen, E Magnus M Ohman, Schuyler Jones, Bradi B Granger
Journal: Circulation (2021)

Background: Research on the patient experience during cardiac catheterization is lacking. Opportunity exists to improve the delivery of procedural sedation to positively impact patient’s report of pain, comfort and satisfaction. We aim to evaluate if the time interval between procedural sedation and subcutaneous lidocaine influences patient experience. Methods: We conducted a prospective, randomized controlled study to determine the effect of 2 time intervals ( &lt; 6 minutes vs &gt; 7 minutes) on 1) total medication dosage, 2) patient-reported and observed pain and 3) patient satisfaction in 175 adults undergoing elective, outpatient cardiac cath from December 2020 to April 2021. Patient reported pain and satisfaction were assessed using the Procedural Sedation Assessment Survey. Observed pain was assessed using the Behavioral Pain Assessment Tool. Generalized linear mixed models were used to analyze the effect of time interval on total medication dose, pain and satisfaction. Results: Of 175 patients randomized, 9 were excluded and 5 withdrew. In the final sample (n=161), the mean age was 62 (SD 13.4), a majority were male (106, 66%), white (117, 74%), with a mean BMI of 28.5 (SD 5.6). Total procedural sedation did not differ between groups. Likewise, patient-reported pain and satisfaction and observed measures of pain did not differ, even after adjustment for age, sex, race, BMI, fellow involvement, vascular access and procedure type. A 3-way interaction was found between procedure type, group assignment, and reported pain during the procedure (p=0.03). Patients undergoing PCI, with intervals &lt; 6 minutes self-reported more intra-procedural pain, despite post hoc analysis showing patients undergoing PCI had higher total medication dosages of both fentanyl and midazolam (p&lt;0.001 &amp; p&lt;0.001) in both groups. Conclusions: No differences were found between groups related to total medication dose, pain or satisfaction regardless of timing between sedation and lidocaine. However, the findings suggest that longer intervals may reduce reported pain among patients undergoing PCI. Further investigation of sedation timing during PCI is needed to potentially improve the patient experience.
Immunocompromised children and young people are at no increased risk of severe COVID-19
Authors: H. Chappell, R. Patel, C. Driessens, A.W. Tarr, W.L. Irving, P.J. Tighe, H.J. Jackson, T. Harvey-Cowlishaw, L. Mills, M. Shaunak, D. Gbesemete, A. Leahy, J.S. Lucas, S.N. Faust, H. de Graaf
Journal: Journal of Infection (2021)
Sars-Cov-2 T-Cell Response in Allogeneic Hematopoietic Stem Cell Recipients Following Two Doses of BNT162b2 Vaccine
Authors: Beatrice Clemenceau, Thierry Guillaume, Marianne Coste-Burel, Pierre Peterlin, Alice Garnier, Amandine Le Bourgeois, Berthe-Marie Imbert, Thomas Drumel, Béatrice Mahé, Viviane Dubruille, Nicolas Blin, Anne Lok, Cyrille Touzeau, Thomas Gastinne, Benoit Tessoulin, Maxime Jullien, Sophie Vantyghem, Jocelyn Ollier, Marie C Bene, Philippe Moreau, Steven Le Gouill, Henri Vie, Patrice Chevallier
Journal: Blood (2021)
Polymorphonuclear myeloid-derived suppressor cells impair the anti-tumor efficacy of GD2.CAR T-cells in patients with neuroblastoma
Authors: Nicola Tumino, Gerrit Weber, Francesca Besi, Francesca Del Bufalo, Valentina Bertaina, Paola Paci, Linda Quatrini, Laura Antonucci, Matilde Sinibaldi, Concetta Quintarelli, Enrico Maggi, Biagio De Angelis, Franco Locatelli, Lorenzo Moretta, Paola Vacca, Ignazio Caruana
Journal: Journal of Hematology & Oncology (2021)

Abstract The outcome of patients affected by high-risk or metastatic neuroblastoma (NB) remains grim, with ≥ 50% of the children experiencing relapse or progression of the disease despite multimodal, intensive treatment. In order to identify new strategies to improve the overall survival and the quality of life of these children, we recently developed and optimized a third-generation GD2-specific chimeric antigen receptor (CAR) construct, which is currently under evaluation in our Institution in a phase I/II clinical trial (NCT03373097) enrolling patients with relapsed/refractory NB. We observed that our CAR T-cells are able to induce marked tumor reduction and even achieve complete remission with a higher efficiency than that of other CAR T-cells reported in previous studies. However, often responses are not sustained and relapses occur. Here, we demonstrate for the first time a mechanism of resistance to GD2.CAR T-cell treatment, showing how polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) increase in the peripheral blood (PB) of NB patients after GD2.CAR T-cell treatment in case of relapse and loss of response. In vitro, isolated PMN-MDSC demonstrate to inhibit the anti-tumor cytotoxicity of different generations of GD2.CAR T-cells. Gene-expression profiling of GD2.CAR T-cells “conditioned” with PMN-MDSC shows downregulation of genes involved in cell activation, signal transduction, inflammation and cytokine/chemokine secretion. Analysis of NB gene-expression dataset confirms a correlation between expression of these genes and patient outcome. Moreover, in patients treated with GD2.CAR T-cells, the frequency of circulating PMN-MDSC inversely correlates with the levels of GD2.CAR T-cells, resulting more elevated in patients who did not respond or lost response to the treatment. The presence and the frequency of PMN-MDSC in PB of high-risk and metastatic NB represents a useful prognostic marker to predict the response to GD2.CAR T-cells and other adoptive immunotherapy. This study underlines the importance of further optimization of both CAR T-cells and clinical trial in order to target elements of the tumor microenvironment.
Retrospective Comparison between 12-Gray and 8-Gray Total Body Irradiation (TBI) before Allogeneic Hematopoietic Cell Transplantation in Patients with Acute Lymphoblastic Leukemia in First Complete Remission
Authors: Alexandros Spyridonidis, Myriam Labopin, Bipin B. Savani, Sebastian Giebel, Christoph Schmid, Zinaida Peric, Gesine Bug, Stefan Schönland, Nicolaus Kröger, Matthias Stelljes, Thomas Schroeder, Andrew McDonald, Igor Wolfgang Blau, Martin Bornhäuser, Montserrat Rovira, Wolfgang Bethge, Andreas Neubauer, Arnold Ganser, Jean-Henri Bourhis, Matthias Edinger, Bruno Lioure, Gerald Wulf, Kerstin Schaefer-Eckart, Mutlu Arat, Ali Bazarbachi, Arnon Nagler, Mohamad Mohty
Journal: Blood (2021)
Brexucabtagene Autoleucel for Relapsed/Refractory Mantle Cell Lymphoma: Real World Experience from the US Lymphoma CAR T Consortium
Authors: Yucai Wang, Preetesh Jain, Frederick L. Locke, Javier Munoz, Matthew J. Maurer, Amer Beitinjaneh, Matthew J. Frank, Saurabh Dahiya, Joseph P. McGuirk, Miriam T. Jacobs, Andre H. Goy, Julie M. Vose, Brian T. Hill, Olalekan O. Oluwole, Abhinav Deol, Bijal D. Shah, Jonas Paludo, Trent Wang, Lazaros J. Lekakis, David B. Miklos, Aaron P. Rapoport, Armin Ghobadi, Sattva S. Neelapu, Yi Lin, Michael Wang, Michael D. Jain
Journal: Blood (2021)
Sleep-disordered breathing and ventilatory chemosensitivity in first ischaemic stroke patients: a prospective cohort study
Authors: Sébastien Baillieul, Sébastien Bailly, Olivier Detante, Sarah Alexandre, Marie Destors, Rita Clin, Marjorie Dole, Jean-Louis Pépin, Renaud Tamisier
Journal: Thorax (2021)

Rationale Sleep-disordered breathing (SDB) is highly prevalent after stroke. The clinical and ventilatory chemosensitivity characteristics of SDB, namely obstructive, central and coexisting obstructive and central sleep apnoea (coexisting sleep apnoea) following stroke are poorly described. Objective To determine the respective clinical and ventilatory chemosensitivity characteristics of SDB at least 3 months after a first ischaemic stroke. Methods Cross-sectional analysis of a prospective, monocentric cohort conducted in a university hospital. 380 consecutive stroke or transient ischaemic attack patients were screened between December 2016 and December 2019. Measurements and main results Full-night polysomnography, and hypercapnic ventilatory response were performed at a median (Q1; Q3) time from stroke onset of 134.5 (97.0; 227.3) days. 185 first-time stroke patients were included in the analysis. 94 (50.8%) patients presented no or mild SDB (Apnoea-Hypopnoea Index &lt;15 events/hour of sleep) and 91 (49.2%) moderate to severe SDB, of which 52 (57.1%) presented obstructive sleep apnoea and 39 (42.9%) coexisting or central sleep apnoea. Obstructive sleep apnoea patients significantly differed regarding their clinical presentation from patients with no or mild SDB, whereas there was no difference with coexisting and central sleep apnoea patients. The latter presented a higher frequency of cerebellar lesions along with a heightened hypercapnic ventilatory response compared with no or mild SDB patients. Conclusion SDB in first-time stroke patients differ in their presentation by their respective clinical traits and ventilatory chemosensitivity characteristics. The heightened hypercapnic ventilatory response in coexisting and central sleep apnoea stroke patients may orientate them to specific ventilatory support.
Abstract 9744: <i>Cardiovascular Stroke Nursing Best Abstract Award</i> : Investigating Sexual Identity Disparities in Hypertension and Hypertension Treatment Among Adults
Authors: Yashika Sharma, Jacquelyn Y Taylor, Tonda Hughes, Billy Caceres
Journal: Circulation (2021)

Introduction: Recent evidence suggests that sexual minority (e.g., gay/lesbian, bisexual) adults are at increased risk for hypertension. However, sexual identity disparities in the use of anti-hypertensive medications among adults with hypertension have not been examined. We sought to investigate sexual identity differences in diagnosis of hypertension and use of anti-hypertensive medication among adults in the United States. Hypothesis: Sexual minority adults will have higher odds of hypertension and use of anti-hypertensive medication than heterosexual adults. Methods: We analyzed data from the Behavioral Risk Factor Surveillance System (2015-2019) to examine sexual identity differences in diagnosis of hypertension and use of anti-hypertensive medication. We ran sex-stratified logistic regression models to estimate the odds ratios of diagnosis of hypertension and use of anti-hypertensive medication among sexual minority and heterosexual adults (reference group). Models were adjusted for demographics, insurance, body mass index, and smoking status. Results: The sample included 424,084 participants; 95.8% were heterosexual, 1.8% were gay or lesbian, and 2.3% were bisexual. Participants had a mean age of 49.6 (±16.9) years. Compared to heterosexual participants of the same sex, gay men (AOR 1.24, 95% CI = 1.08-1.42) and bisexual women (AOR 1.17, 95% CI = 1.02-1.35) were more likely to report having been diagnosed with hypertension. Among men diagnosed with hypertension those who identified as gay were more likely than heterosexual men to report current use of anti-hypertensive medication (AOR 1.44, 95% CI = 1.13-1.83). Among women with diagnosed hypertension, bisexual women had lower odds of current use of anti-hypertensive medication (AOR 0.70, 95% CI = 0.55-0.89). No differences were identified when lesbian women and bisexual men were compared to their heterosexual peers of the same sex. Conclusion: Gay men and bisexual women had a higher prevalence of hypertension than their heterosexual counterparts of the same sex. Bisexual women may also be at higher risk for under-treated hypertension than heterosexual women. Future research should examine factors that contribute to hypertension disparities among gay men and bisexual women.
Changes in behaviour last year led to fall in antibiotic resistant infections
Authors: Elisabeth Mahase
Journal: BMJ (2021)

Changes in behaviour last year led to fall in antibiotic resistant infections Elisabeth MahaseThe incidence of antibiotic resistant bloodstream infections fell in England in 2020 for the first time since 2016, although numbers still remain higher than six years ago, data from the UK Health Security Agency have shown. 1There were 55 384 antibiotic resistant bloodstream infections in 2020, down from 65 583 in 2019.Deaths attributable to antibiotic resistant bacteria also fell, to 2228 last year, from 2596 the year before.The reduction in antibiotic resistance in 2020 was mainly driven by fewer Escherichia coli bloodstream infections, the report found.The agency said the reduction in all mono-microbial bloodstream infections, from 137 655 in 2019 to 127 449 in 2020, and in antibiotic resistant bloodstream infections was likely to have been due to changes in behaviour brought on by the covid-19 pandemic, such as less social mixing, enhanced hand hygiene, and fewer people in hospital.It said this indicated it was likely there would be a rise in numbers of resistant infections as pandemic restrictions end.The incidence of bloodstream infections of each of the key individual pathogens decreased from 2019 to 2020, with the largest relative decrease, of 59%, seen for Streptococcus pneumoniae, from 8.7 cases per 100 000 population in 2019 to 3.6 per 100 000 in 2020.However, the report found that although the total number of infections and resistant infections fell in 2020 the proportion of bloodstream infections that were resistant to one or more antibiotics was the same as in 2019 and actually higher than in 2016.
Abstract 9430: A Novel Soluble Epoxide Hydrolase Peptide Vaccine Attenuates Cardiac Remodeling After Myocardial Infarction Through Angiogenesis
Authors: Takahiro Kitsuka, Aya Shiraki, Jun-ichi Oyama, Hironori Nakagami, Atsushi Tanaka, Koichi Node
Journal: Circulation (2021)

Introduction: Vaccination therapy has long-lasting effects and solves medication non-adherence. However, vaccination therapy on myocardial infarction (MI) has not been developed. Epoxyeicosatrienoic acids (EETs) play an important role in cardio-protective mechanisms through angiogenesis. Here, we developed a soluble epoxide hydrolase (sEH) peptide vaccine to increase the level of EETs and assessed its therapeutic effect for MI-induced heart failure. Hypothesis: We predicted that neovascularization by a sEH vaccine would reduce infract size and prevent post-MI cardiac remodeling. Methods and Results: We made a sEH peptide vaccine based on the amino-acid sequences and administrated the vaccine to rats. ELISA showed that the vaccine induced anti-sEH antibody. Mass spectrometry also confirmed that the vaccine significantly increased blood EETs levels compared to the saline group (P=0.007). We evaluated the effects of the sEH vaccine in the rat model of MI. One week after the left anterior descending artery (LAD) ligation, the vaccinated group significantly suppressed the increase of left ventricular systolic diameter (LVDs) and prevented the decline in left ventricular anterior wall (LVAW), fractional shortening (FS), and ejection function (EF) in echocardiography (P&lt;0.001, P&lt;0.001, P=0.002, and P&lt;0.001 respectively). With the pathological evaluation of the hearts, it was clear that the number of micro-vessels increased in the vaccinated group by immunostaining for CD31 and α-SMA (P=0.015 and P=0.027 respectively). Azan staining showed that infarct-induced fibrosis was lower in the vaccinated group (P=0.029). Western blot showed higher vascular endothelial growth factor (VEGF) expressions of heart muscles in the vaccinated group (P=0.040). Conclusion: The sEH vaccine therapy for MI induces angiogenesis, which promotes reverse cardiac remodeling. This vaccine is expected to be a treatment option to prevent heart failure after MI.
The Profiling of Circulating Tumor DNA in Pediatric Mature B-Cell Non-Hodgkin Lymphoma（B-NHL）: A Multicenter and Prospective Clinical Study
Authors: Juan Wang, Haixia Guo, Cai Yun, Huiqin Chen, Liangchun Yang, Huihong Dou, Xin Tian, Hao Xiong, M. James You, Xiaoyu Hong, Chuqiao Liang, Zijun Zhen, Jia Zhu, Suying Lu, Feifei Sun, Junting Huang, Yizhuo Zhang
Journal: Blood (2021)
Engineered Hypoimmune Allogeneic CAR T Cells Exhibit Innate and Adaptive Immune Evasion Even after Sensitization in Humanized Mice and Retain Potent Anti-Tumor Activity
Authors: Xiaomeng Hu, Mo Dao, Kathy White, Corie Gattis, Ryan Clarke, Sam Landry, Ron Basco, Eleonore Tham, Andrew Tucker, Emily Luo, Christopher Bandoro, Elaine Chu, Chi Young, Aaron E. Foster, William E Dowdle, Edward J Rebar, Terry J. Fry, Sonja Schrepfer
Journal: Blood (2021)
Abstract 9495: Prognostic Value of Machine Learning on Clinical Parameters for Cardiac Prognosis in Patinets with Acute Congestive Heart Failure
Authors: Masato Shimizu, Hiroko Miyazaki, shummo cho, Yoshiki Misu, Ryo Tateishi, Masao Yamaguchi, Yosuke Yamakami, Hiroshi Shimada, Tomoko Manno, Ami Isshiki, Shigeki Kimura, Hiroyuki Fujii, Makoto Suzuki, Mitsuhiro Nishizaki, Tetsuo Sasano
Journal: Circulation (2021)

Introduction: Congestive heart failure (CHF) in acute phase, many clinical fundamental parameters including vital sign, laboratory data, or initial treatment were investigated, and we can roughly estimate the prognosis with the parameters. However, machine learning method for prediction of the prognosis is still challenging. Hypothesis: Machine learning methods have higher performance for predicting cardiac prognosis in patients with CHF than conventional statistical model. Methods: We enrolled consecutive 300 patients with CHF (79.5±12.1 years, 158 Males). Patients with acute coronary syndrome, mechanical circulatory support cases, and cardio-pulmonary arrest cases were excluded. Objective variable was set as cardiac death in one year. First, multivariate stepwise logistic regression analysis with Akaike’s information criterion (AIC) was performed, and extracted parameters which had the most versatile predictive value. Propensity score (PS) was calculated with the extracted parameters, and the prediction model constructed by cut-off value of ROC curve analysis of PS. Next, machine learning (random forest method and deep learning) to build predictive model was performed with the predictors. Finally, accuracy of each predictive model was compared. Results: Thirty cases showed cardiac death in one year. Logistic regression with AIC extracted 8 predictors, and the cut off-value of propensity score with the 8 parameters was 0.110. The accuracy was 0.714 and area under ROC (AUROC) was 0.836. Conversely, random forest method demonstrated the accuracy as 0.927, AUROC 0.860. On deep learning, the accuracy was 0.937 and AUROC 0.901.The top 4 high feature importance of random forest were Cl/red blood cell count/pH/Anion Gap. However, accuracy of those predictors was lower than that of machine learning. Conclusions: Machine learning was a powerful tool to predict cardiac prognosis of CHF, comparing with conventional statistical model.
Association between vaccination with the BNT162b2 mRNA COVID-19 vaccine and Bell's palsy: a population-based study
Authors: Rana Shibli, Ofra Barnett, Zomoroda Abu-Full, Naomi Gronich, Ronza Najjar-Debbiny, Ilana Doweck, Gad Rennert, Walid Saliba
Journal: The Lancet Regional Health - Europe (2021)

An excess risk of Bell's palsy has been suggested after mRNA vaccines. We examined the association between the BNT162b2 mRNA COVID-19 vaccine and Bell's palsy.
Staphylococcus aureus bloodstream infections: diverging trends of meticillin-resistant and meticillin-susceptible isolates, EU/EEA, 2005 to 2018
Authors: Carlo Gagliotti, Liselotte Diaz Högberg, Hanna Billström, Tim Eckmanns, Christian G Giske, Ole E Heuer, Vincent Jarlier, Gunnar Kahlmeter, Danilo Lo Fo Wong, Jos Monen, Stephen Murchan, Gunnar Skov Simonsen, Maja Šubelj, Arjana Tambić Andrašević, Dorota Żabicka, Helena Žemličková, Dominique L Monnet
Journal: Eurosurveillance (2021)

BackgroundInvasive infections caused by Staphylococcus aureus have high clinical and epidemiological relevance. It is therefore important to monitor the S. aureus trends using suitable methods.AimThe study aimed to describe the trends of bloodstream infections (BSI) caused by meticillin-resistant S. aureus (MRSA) and meticillin-susceptible S. aureus (MSSA) in the European Union (EU) and the European Economic Area (EEA).MethodsAnnual data on S. aureus BSI from 2005 to 2018 were obtained from the European Antimicrobial Resistance Surveillance Network (EARS-Net). Trends of BSI were assessed at the EU/EEA level by adjusting for blood culture set rate (number of blood culture sets per 1,000 days of hospitalisation) and stratification by patient characteristics.ResultsConsidering a fixed cohort of laboratories consistently reporting data over the entire study period, MRSA percentages among S. aureus BSI decreased from 30.2% in 2005 to 16.3% in 2018. Concurrently, the total number of BSI caused by S. aureus increased by 57%, MSSA BSI increased by 84% and MRSA BSI decreased by 31%. All these trends were statistically significant (p < 0.001).ConclusionsThe results indicate an increasing health burden of MSSA BSI in the EU/EEA despite a significant decrease in the MRSA percentage. These findings highlight the importance of monitoring antimicrobial resistance trends by assessing not only resistance percentages but also the incidence of infections. Further research is needed on the factors associated with the observed trends and on their attributable risk.
Progress Against Cancer Mortality 50 Years After Passage of the National Cancer Act
Authors: Tyler B. Kratzer, Rebecca L. Siegel, Kimberly D. Miller, Hyuna Sung, Farhad Islami, Ahmedin Jemal
Journal: JAMA Oncology (2021)

This cohort study compares current cancer mortality with that in 1971, 50 years after the National Cancer Act designated defeating cancer a national priority and allocated substantial resources to the National Cancer Institute.
Cardiovascular Side Effects of Chimeric Antigen Receptor (CAR) T-Cell Products: A Single Center Experience in a Minority Rich, Ethnically Diverse Real-World Cohort
Authors: Sumaira Zareef, Astha Thakkar, Ryann Quinn, An Tran, Alyssa De Castro, Jennat Mustafa, Fariha Khatun, Amanda Lombardo, Latoya Townsend Nugent, Richard Elkind, Kira Gritsman, Mendel Goldfinger, Noah Kornblum, Aditi Shastri, Ioannis Mantzaris, Lizamarie Bachier Rodriguez, Lili Zhang, Amit Verma, Ira Braunschweig, R. Alejandro Sica
Journal: Blood (2021)