tbuckley/cabot-search huggingface dataset:
Association of Maternal-Clinician Ethnic Concordance With Latinx Youth Receipt of Family-Centered Care
Authors: Cinthya K. Alberto, Jessie Kemmick Pintor, Ana Martínez-Donate, Loni Philip Tabb, Brent Langellier, Jim P. Stimpson
Journal: JAMA Network Open (2021)

<h3>Importance</h3> Disparities in medical home provisions, including receipt of family-centered care (FCC), have persisted for Latinx youths in the US. <h3>Objective</h3> To examine the association between maternal-clinician ethnic concordance and receipt of FCC among US-born Latinx youths. <h3>Design, Setting, and Participants</h3> A cross-sectional secondary analysis of data from the Medical Expenditure Panel Survey from January 1, 2010, to December 31, 2017, was conducted. Data analysis was performed from January 6 to February 3, 2020. Latinx youths (age, ≤17 years) born in the US who had a usual source of care and used care in the past year, their Latina mothers (age, 18-64 years), and youths’ health care clinician characteristics (eg, race, ethnicity, and sex) were evaluated using χ<sup>2</sup>tests and propensity-score matching methods. <h3>Main Outcomes and Measures</h3> Maternal reports on whether their youths’ clinician listened carefully to the parent, explained things in a way the parent could understand, showed respect, and spent enough time with the patient. <h3>Results</h3> There were 2515 US-born Latinx youths with linked maternal characteristics during the study period; 51.67% (95% CI, 48.87%-54.45%) of the youths were male, mean (SD) age was 8.48 (0.17) years (30.86% [95% CI, 28.39%-33.44%] were between ages 5 and 9 years), 61.53% (95% CI, 57.15%-65.74%) had public insurance coverage, and 39.89% (95% CI, 32.33%-47.89%) had mothers who were ethnically concordant with the youths’ medical care clinician. We found that for youths with maternal-clinician ethnic concordance, the probabilities of reporting FCC were significantly higher than they would have been in the absence of concordance: that the medical care clinician listened carefully to the parent (average treatment effect on the treated [ATET], 5.44%; 95% CI, 2.14%-8.74%), explained things in a way the parent could understand (ATET, 4.82%; 95% CI, 1.60%-8.03%), showed respect for what the parent had to say (ATET, 5.51%; 95% CI, 2.58%-8.45%), and spent enough time with the patient (ATET, 5.28%; 95% CI, 1.68%-8.88%). <h3>Conclusions and Relevance</h3> Given the increase of Latinx populations and the simultaneous shortage of underrepresented minority health care clinicians, the findings of this study suggest that increasing the number of clinicians from underrepresented minority backgrounds and ethnic-concordant parental-clinician relationships may help reduce disparities in receipt of medical home provision among US-born Latinx youths.
Outcomes By Best Response with Hypomethylating Agent Plus Venetoclax in Adults with Previously Untreated Acute Myeloid Leukemia
Authors: Virginia Olivia Volpe, Akriti G Jain, Onyee Chan, Eric Padron, David A. Sallman, Rami S. Komrokji, Jeffrey E. Lancet, Kendra Sweet
Journal: Blood (2021)
Efficacy and Safety of Ciltacabtagene Autoleucel in Patients With Relapsed/Refractory Multiple Myeloma: CARTITUDE-1 Subgroup Analysis
Authors: Andrzej Jakubowiak, Saad Z. Usmani, Jesus G. Berdeja, Mounzer Agha, Adam D Cohen, Parameswaran Hari, Jordan M. Schecter, Deepu Madduri, Tzu-Min Yeh, Yunsi Olyslager, Arnob Banerjee, Carolyn C. Jackson, Alicia Allred, Enrique Zudaire, William Deraedt, Changwei Zhou, Dong Geng, Lida Pacaud, Yi Lin, Thomas Martin, Sundar Jagannath
Journal: Blood (2021)
Surgical Experience from the Phase III STASEY Trial of Emicizumab Prophylaxis in Persons with Hemophilia A with FVIII Inhibitors: Final Analysis
Authors: Giancarlo Castaman, Jerzy Windyga, Hazza Alzahrani, Susan Robson, Fabian Sanabria, Monet Howard, Víctor Jiménez-Yuste
Journal: Blood (2021)
Carfilzomib-Lenalidomide-Dexamethasone Consolidation in Myeloma Patients with a Positive FDG PET/CT after Upfront Autologous Stem Cell Transplantation: A Phase II Study (CONPET)
Authors: Jakob Nordberg Nørgaard, Niels Abildgaard, Anna Lysén, Galina Tsykunova, Annette Juul Vangsted, Cristina João, Nora Remen, James P Connelly, Mona-Elisabeth R. Revheim, Fredrik H. Schjesvold
Journal: Blood (2021)
Transmission of Serum Hepatitis
Authors: Lewellys F. Barker
Journal: JAMA (1996)

There is evidence that transmission of serum hepatitis is associated with transmission of virus-like particles, approximately, 20 millimicron in diameter, containing the Australia or serum hepatitis (SH) antigen, which is currently referred to as the hepatitis associated antigen (HAA). Virus-like particles containing HAA were in the following materials, inoculation of which produced serum hepatitis: (1) a pool of human plasma, (2) serum obtained during the acute phase of hepatitis from a recipient of the plasma pool, (3) a preparation of human thrombin, and (4) serum from a proved hepatitis carrier. The HAA appeared in the serum samples of 61 individuals inoculated with these materials; serum hepatitis developed in 38 of them. Inoculation of dilutions of the plasma pool showed that serum hepatitis can be transmitted by materials containing HAA in amounts too low to be detected by current techniques.
Environmental Displacement and Mental Well-Being in Banjarnegara, Indonesia
Authors: Kate Burrows, Dicky C. Pelupessy, Kaveh Khoshnood, Michelle L. Bell
Journal: Environmental Health Perspectives (2021)

Residential moves (displacement) owing to climate- and weather-related disasters may significantly impact mental health. Despite the growing risk from climate change, health impacts of environmental-mobility remain understudied.We assessed the effects of displacement on the association between landslides and changes in perceived mental well-being in Banjarnegara, Indonesia. We also investigated whether sociodemographics (age, sex, level of education, household-level income, or employment in agriculture) and landslide characteristics (number and severity of landslides) were associated with differing odds of relocation after experiencing landslides.In this cross-sectional study, we surveyed 420 individuals who experienced landslides between 2014 and 2018 to assess perceived changes in mental well-being, comparing after landslide exposure to before landslide exposure. We used a novel six-item measure that was created in collaboration with the local community to compare perceived changes between those who were displaced by landslides and those who were not displaced, using logistic and multinomial regressions adjusted for sociodemographic characteristics. We then assessed whether the odds of displacement differed based on sociodemographic characteristics and landslide exposure characteristics, using logistic regressions.Those who were displaced were more likely than those who were not displaced to report perceived increases in economic stability [odds ratio (OR)=3.06; 95% confidence interval (CI): 1.45, 6.46], optimism (OR=4.01; 95% CI: 1.87, 8.61), safety (OR=2.71; 95% CI: 1.44, 5.10), religiosity (OR=1.92; 95% CI: 1.03, 3.65), and closeness with community (OR=1.90; 95% CI: 1.10, 3.33) after landslides compared with before their first landslide during the study period. More frequent landslide exposures were associated with reduced odds of relocation, but more severe landslides were associated with increased odds of relocation.These findings suggest that landslides affect the mental well-being not only of those who are displaced but also of those who are left behind. Further, this work supports the need for community-based participatory research to fully capture the health impacts of environmental mobility. https://doi.org/10.1289/EHP9391.
Association Between Atopic Dermatitis and Height, Body Mass Index, and Weight in Children
Authors: Mathew N. Nicholas, Charles D. G. Keown-Stoneman, Jonathon L. Maguire, Aaron M. Drucker
Journal: JAMA Dermatology (2021)

Atopic dermatitis may be associated with short stature and obesity in children, but most previous studies have been either small or cross-sectional.To evaluate the association between atopic dermatitis and height, body mass index (BMI; calculated as weight in kilograms divided by height in meters squared), and weight throughout childhood.TARGet Kids! (The Applied Research Group for Kids) is an ongoing prospective longitudinal cohort study that collects data at routine physician visits throughout childhood. In this cohort, children aged 5 or younger were followed up into adolescence at regular physician visits at general pediatric and family practices in Toronto, Canada, from June 2008 to February 2021.Parental report of atopic dermatitis.Primary outcomes were length-for-age and BMI-for-age z scores. The secondary outcome was weight-for-age z score. Linear mixed effects models were used to estimate associations between atopic dermatitis and each outcome. In secondary analyses, interaction terms were included between atopic dermatitis and age.A total of 10 611 children were included in the analysis, with mean (SD) baseline age of 23 (20) months; 5070 (47.8%) participants were female. Participants were followed for a median (range) of 28.5 (0.0-158.0) months. A total of 1834 (17.3%) children had atopic dermatitis during follow-up. Atopic dermatitis was associated with lower length-for-age z score (-0.13; 95% CI, -0.17 to -0.09; P < .001), higher BMI z score (0.05; 95% CI, 0.01 to 0.09; P = .008), and lower weight-for-age z score (-0.07; 95% CI, -0.10 to -0.04; P < .001) compared with children without atopic dermatitis. The associations between atopic dermatitis and height and BMI changed with age, diminishing by age 14 years and 5.5 years, respectively. Based on World Health Organization growth tables, children with atopic dermatitis were on average 0.5 cm shorter with 0.2 more BMI units at age 2 years and 0.6 cm shorter with no difference in BMI at age 5 years than children without atopic dermatitis after adjusting for covariates. There was no evidence of interaction between atopic dermatitis and age with respect to weight.In this cohort study, atopic dermatitis was associated with shorter stature, higher BMI, and lower weight in early childhood, but these associations were small and, for height and BMI, attenuated with age and resolved by adolescence.
Effects of BCL11A Shmir-Induced Post-Transcriptional Silencing on Distributions of HbF in Single-RBCs and Reticulocytes
Authors: Nicolas Hebert, Erica B. Esrick, Myriam Armant, Christian Brendel, Marioara Felicia Ciuculescu, Etienne Audureau, John M. Higgins, David A. Williams, Pablo Bartolucci
Journal: Blood (2021)
Molecular and Biological Characterization of Transient Antithrombin Deficiency: A New Concept in Congenital Thrombophilia
Authors: Maria Eugenia Eugenia de la Morena-Barrio, Carlos Bravo-Perez, Belen De La Morena-Barrio, Antonia Miñano, Jose Padilla, Rosa Cifuentes-Riquelme, Pedro Garrido, Vicente Vicente, Javier Corral
Journal: Blood (2021)
Abstract 8907: Fatty-Acid-Binding Protein 3 as a Novel Inducer of Adhesion Molecules in Atherosclerosis
Authors: Yen-Wen Wu, Jaw W Chen, Ting-Ting Chang
Journal: Circulation (2021)

Introduction: Cardiovascular disease is accompanied by a considerable degree of morbidity and mortality, and the pathogenesis is complex. The fatty-acid-binding protein 3 (FABP-3) is a cytoplasmic protein and can be released from injured myocardium. We had demonstrated that FABP-3 was an independent predictor for cardiovascular outcomes in the patients with stable coronary artery disease (CAD). However, the mechanisms of FABP-3 in atherosclerosis were still unknown. Here we supposed that FABP-3 could lead to atherogenesis via activating the adhesion molecules. Methods and Results: Human coronary endothelial cells (HCAECs) and mononuclear cells (MNCs) cultured from CAD patients and healthy subjects were used for the in vitro study. The ox-LDL and TNF-α were used as stimulators in the in vitro experiments. The expressions of adhesion molecule were evaluated by Western blot analysis. MNCs from CAD patients had higher expressions of FABP-3 than those from healthy subjects. In addition, FABP-3 could be further up-regulated by ox-LDL and TNF-α stimulations in both MNCs from CAD patients and healthy subjects. Exogenous of FABP-3 could directly induce the adhesion molecules including integrin β2, integrin α4, and P-selectin glycoprotein ligand 1 expressions in MNCs from CAD patients and healthy subjects. Nevertheless, direct treatments of FABP-3 did not upregulate the adhesion molecules in HCAECs. Also, the adhesiveness of FABP-3-induced adhesiveness of HCAECs to THP-1 monocytic cells was not enhanced. Conclusions: According to the above results, we suggested that FABP-3 could directly lead to the atherogenesis via the MNC activation instead of endothelial cell activation. The findings of the serial studies may not only elucidate the prognostic role of plasma FABP-3 levels in patients with CAD but define the role of FABP-3 on the pathogenesis of atherosclerosis especially its influence in MNCs. The study might clarify the clinical impact of FABP-3 and as a potential novel therapeutic target for atherosclerosis.
Labor Market Attachment in Patients with Myeloproliferative Neoplasms: A Nationwide Matched Cohort Study
Authors: Sarah Friis Christensen, Lise Skovgaard Svingel, Anders Kjærsgaard, Anna Stenling, Björn Paulsson, Christen Lykkegaard Andersen, Christian Fynbo Christiansen, Jesper Stentoft, Jørn Starklint, Marianne Tang Severinsen, Mette Borg Clausen, Morten Hagemann Hilsøe, Henrik Frederiksen, Hans C. Hasselbalch, Marie Bak, Ellen Margrethe Mikkelsen
Journal: Blood (2021)
Risk Assessing Medical Inpatients for Hospital-Acquired Venous Thrombosis: The Medical Inpatients Thrombosis and Hemostasis (MITH) Study
Authors: Neil A. Zakai, Insu Koh, Katherine Wilkinson, Nicholas S Roetker, Andrew D Sparks, Allen B Repp, Ryan M Thomas, Nicholas L Smith, Chris E. Holmes, Mary Cushman
Journal: Blood (2021)
Abstract 9885: Overestimation of Anticoagulant Benefit in Patients with Atrial Fibrillation and Low Life Expectancy: Evidence from 12 Randomized Trials
Authors: Sachin J Shah, Carl van Walraven, FD Richard Hobbs, Stuart J Connolly, Daniel E Singer
Journal: Circulation (2021)

Introduction: Formative anticoagulant RCTs for stroke prevention in atrial fibrillation (AF) were completed before the advent of competing risk methods. Neglecting the competing risk of death can overestimate treatment benefit. This is noteworthy because many patients with AF are frail with limited life expectancy. We determined the overestimation of anticoagulant benefit as a function of life expectancy. Methods: We used patient-level data from 12 anticoagulant RCTs that compared warfarin vs. aspirin or placebo. We estimated each patient’s life expectancy using CDC life tables modified for age, sex, comorbidities, and trial enrollment year. We predicted cumulative stroke incidence with and without anticoagulants at 3 years using a Cox model treating death as a censoring event (“standard model”) and again using a Fine-Gray model treating death as a competing event (“competing risk model”). For each patient, we plot the absolute and relative standard model overestimation compared to the competing risk model. We describe the relationship between life expectancy and log-transformed benefit overestimation (Figure A, B). Results: For the 9548 patients (35% women, mean age 74yrs), the median life expectancy was 11.4yrs (IQR 8.4, 15.3). The overall estimated reduction in stroke incidence at 3 years was 7.7% using a standard model and 6.3% using a competing risk model. The absolute and relative overestimation of the standard model increased exponentially as life expectancy decreased. For example, with a life expectancy of 3 years, a standard model would overestimate absolute benefit by 2.8% (95%CI 2.7-2.9%) and the relative benefit by 29.4% (95%CI 29.3-29.4%). Conclusions: For patients with low life expectancy, the anticoagulant benefit is substantially overestimated using standard survival methods. While anticoagulants reduce the risk of stroke, decision tools should account for life expectancy when estimating benefits for patients with AF.
Experience with IMGN632, a Novel CD123-Targeting Antibody-Drug Conjugate (ADC), in Frontline Patients with Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)
Authors: Naveen Pemmaraju, Giovanni Martinelli, Elisabetta Todisco, Andrew A. Lane, Evelyn Acuña-Cruz, Eric Deconinck, Eunice S. Wang, Kendra Sweet, David A Rizzieri, Giovanni Marconi, Luca Mazzarella, Daniel J. DeAngelo, Pau Montesinos, Federica Gigli, Harry P. Erba, Marina Konopleva, Hagop Kantarjian, Roland B. Walter, Ahmed Aribi, Delphine Lebon, Moshe Y. Levy, Callum M Sloss, Kara E Malcolm, Patrick A Zweidler-McKay, Naval Daver
Journal: Blood (2021)
The Impact of Pre-Apheresis Health Related Quality of Life on Peripheral Blood Progenitor Cell Yield and Donor's Health and Outcome: Secondary Analysis of Rdsafe and BMT CTN 0201
Authors: Nosha Farhadfar, Stephanie Bo-Subait, Kwang Woo Ahn, Brent R. Logan, Heather E. Stefanski, Jack W. Hsu, Sandhya R. Panch, Dennis L. Confer, Claudio Anasetti, Michael A. Pulsipher, Bronwen E. Shaw, John R. Wingard, Galen E. Switzer
Journal: Blood (2021)
Isatuximab in Combination with Chemotherapy in Pediatric Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia or Acute Myeloid Leukemia (ISAKIDS): Interim Analysis
Authors: Andre Baruchel, Jonas Abrahamsson, Yves Bertrand, Oscar Gonzalez, Karsten Nysom, Willy Quinones, Carmelo Rizzari, Jochen Buechner, Simone Cesaro, Joaquin Duarte, Franca Fagioli, Hyoung Jin Kang, Antonis Kattamis, Guy Leverger, Kathleen Ludwig, Monica L Makiya, Concetta Micalizzi, Brigitte Nelken, Camilla Tøndel, Keon Hee Yoo, Inna Ivanina, Claire Brillac, Lynn Wang, Corina Oprea, Giovanni Abbadessa, C. Michel Zwaan
Journal: Blood (2021)
Abstract 9341: Hepatic Steatosis Index and Fibrosis-4 Scores in Patients With Type 2 Diabetes - Post Hoc Analyses from VERTIS CV
Authors: Karen D Corbin, Samuel Dagogo-Jack, Christopher P Cannon, David Z Cherney, Francesco Cosentino, Darren K McGuire, Weichung J Shih, Robert Frederich, Jie Liu, Jianxin Lin, Nilo B Cater, Richard E Pratley
Journal: Circulation (2021)

Introduction: Given the potential link between non-alcoholic fatty liver disease and increased cardiovascular (CV) risk, the associations between markers of hepatic steatosis/fibrosis with CV and kidney outcomes were explored. Methods: These post hoc analyses were conducted on data from the VERTIS CV trial that randomized patients with type 2 diabetes (T2D) and atherosclerotic CV disease (ASCVD) to ertugliflozin 5 or 15 mg or placebo, with all randomized groups pooled for the present analyses. The presence of hepatic steatosis was estimated by hepatic steatosis index (HSI; 8 х ALT/AST + BMI + 2 if T2D + 2 if female); and for hepatic fibrosis, fibrosis-4 score (FIB-4; [age х AST]/[platelets count х √ALT]). Patients were divided into quartiles (Q1 to Q4) according to baseline for each score. CV and kidney outcomes (CV death/myocardial infarction/stroke [MACE]; hospitalization for heart failure [HHF]/CV death; CV death; HHF; and sustained ≥40% decrease in eGFR from baseline/dialysis or transplantation/kidney death) were stratified by baseline HSI and FIB-4 quartiles. Results: Among 8246 patients, the mean age was 64.4 years, mean BMI 32.0 kg/m 2 , mean HSI 44.0, and mean FIB-4 score 1.34. Event rates of MACE, HHF/CV death, CV death, and HHF increased with FIB-4 quartile ( Fig A ). The hazard ratios (HR, 95% CI) of events by FIB-4 quartile (Q4 vs Q1) were 1.48 (1.25, 1.76), 2.0 (1.63, 2.51), 1.85 (1.45, 2.36), and 2.94 (1.98, 4.37) for MACE, HHF/CV death, CV death, and HHF, respectively. The kidney composite did not differ across FIB-4 quartiles. CV and kidney outcomes did not differ across HSI quartiles, except for higher incidence of HHF in the upper HSI quartile (HR [95% CI], Q4 vs Q1: 1.52 [1.07, 2.17]) ( Fig B ). Conclusion: In VERTIS CV, baseline fibrosis scores were associated with incident CV events in patients with T2D and ASCVD, despite the upper cutoff excluding advanced fibrosis. Steatosis only correlated with HHF, and neither measure was associated with the composite kidney outcome.
Efficacy and Safety of Recombinant Human-Mouse Chimeric Anti-CD20 Monoclonal Antibody (SCT400) Combined with CHOP in Patients with Treatment-Naïve Diffuse Large B-Cell Lymphoma: A Multicenter, Randomized, Single-Blind, Parallel Active-Controlled, Phase III Study
Authors: Yuankai Shi, QingYuan Zhang, Xiaonan Hong, Zhen Wang, Yuhuan Gao, Liqun Zou, Hong Cen, Lin Gui, Yufu Li, Jifeng Feng, Zhao Wang, Mingzhi Zhang, Chuan Jin, Weihua Zhang, Jianda Hu, Chengyun Zheng, Zhendong Zheng, Liling Zhang, Shaoshui Chen, Yunhong Huang, Yun Tang, Yajie Gao, Miaowang Hao, Xiaoling Li, Chunkang Chang, Haiyan Yang, Hui Wu, Lida Shen, Xiaoyan Ke, Liangming Zhang, Yaming Xi, Linhua Yang, Liangzhi Xie
Journal: Blood (2021)
Safety, Feasibility and Healthcare Cost Differences between Inpatient and Outpatient Mobilization Chemotherapy for Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma: A Single Center Experience
Authors: Edwin Thong, Michelle Poon, Pamela Lim, Shikha Kumari, . Yelly, Hui Li Lim, Jedidah Lieow, Yee Mei Lee, Lip Kun Tan, Liang Piu Koh, Wee Joo Chng, Joanne Lee
Journal: Blood (2021)
Quality of Life in Patients &amp;lt;=70 Years of Age with Chronic Lymphocytic Leukemia Treated Frontline with Ibrutinib-Rituximab Versus Fludarabine Cyclophosphamide Rituximab: Analysis from ECOG-ACRIN E1912
Authors: Priyanka A Pophali, Xin Victoria Wang, Fengmin Zhao, Neil E. Kay, Curtis A. Hanson, Mary L. Thomas, Susan M. O'Brien, Jacqueline Barrientos, Elisabeth M. Paietta, Jose F. Leis, Cong Christine Zhang, Steven Coutre, Paul M. Barr, Amanda Cashen, Anthony R. Mato, Avina Singh, Richard F. Little, Harry P. Erba, Richard M. Stone, Mark R. Litzow, Martin S. Tallman, Tait Shanafelt, Lynne I. Wagner
Journal: Blood (2021)
<i>Txnip</i> enhances Fitness of <i>Dnmt3a</i>-Mutant Hematopoietic Stem Cells Via <i>p21</i>
Authors: Christine R Zhang, Elizabeth Leigh Ostrander, Jiameng Sun, Cates Mallaney, Hamza Celik, Won Kyun Koh, Katherine Y. King, Paul Gontarz, Grant A. Challen
Journal: Blood (2021)
To code or not to code chronic pulmonary aspergillosis associated malnutrition in PMSI database: that is the problem…
Authors: Thomas Maitre, Jonathan Cottenet, Cendrine Godet, Adrien Roussot, Nafiz Abdoul Carime, Vichita Ok, Antoine Parrot, Philippe Bonniaud, Catherine Quantin, Jacques Cadranel
Journal: European Respiratory Journal (2021)

We read with interest the letter from S. Jouneau and co-workers titled " To be malnourished or not to be malnourished: that is the question! ", referencing our study in which we overviewed the epidemiology and prognostic of chronic pulmonary aspergillosis (CPA) in France [1]. Based on the French nationwide administrative hospital database (PMSI), which is designed to include discharge abstracts for all inpatients admitted to public and private hospitals in France, we reported that malnutrition is one of the most frequent underlying conditions concerning 38 to 44% of CPA patients from 2014 to 2018. Moreover, in CPA incident cases, malnutrition increased significantly in-hospital mortality at their first hospitalisation but also at 1 and 5 years, in multivariate analyses. Malnutrition is a crucial prognostic factor in chronic pulmonary aspergillosis patients. Patient survival decreases according to malnutrition severity. <https://bit.ly/3krOBJw>