Metabolically Healthy Obesity and Development of Chronic Kidney Disease
Authors: Henry S. Kahn, Meda E. Pavkov
Journal: Annals of Internal Medicine (2016)

Letters15 November 2016Metabolically Healthy Obesity and Development of Chronic Kidney DiseaseHenry S. Kahn, MD and Meda E. Pavkov, MD, PhDHenry S. Kahn, MDFrom Centers for Disease Control and Prevention, Atlanta, Georgia.Search for more papers by this author and Meda E. Pavkov, MD, PhDFrom Centers for Disease Control and Prevention, Atlanta, Georgia.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L16-0407 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their longitudinal study of metabolically healthy workers, Chang and colleagues (1) showed that higher BMI categories were associated with an increased incidence of CKD. They interpreted this finding as an adverse consequence of adiposity. However, their description of participant subgroups suggests that the association reported between elevated BMI and incident CKD was driven by relationships found primarily among older adults, men, and persons who exercise frequently. These are subgroups in which BMI status might reflect variations in the preservation or formation of muscle mass rather than the accumulation of adipose tissue. Greater muscle mass leads to ...References1. Chang Y, Ryu S, Choi Y, Zhang Y, Cho J, Kwon MJ, et al. Metabolically healthy obesity and development of chronic kidney disease: a cohort study. Ann Intern Med. 2016;164:305-12. [PMID: 26857595]. doi:10.7326/M15-1323 LinkGoogle Scholar2. Levey AS, Becker C, Inker LA. Glomerular filtration rate and albuminuria for detection and staging of acute and chronic kidney disease in adults: a systematic review. JAMA. 2015;313:837-46. [PMID: 25710660] doi:10.1001/jama.2015.0602 CrossrefMedlineGoogle Scholar3. Zhao D, Kim MH, Pastor-Barriuso R, Chang Y, Ryu S, Zhang Y, et al. A longitudinal study of association between adiposity markers and intraocular pressure: the Kangbuk Samsung Health Study. PLoS One. 2016;11:e0146057. [PMID: 26731527] doi:10.1371/journal.pone.0146057 CrossrefMedlineGoogle Scholar4. Bastien M, Poirier P, Lemieux I, Després JP. Overview of epidemiology and contribution of obesity to cardiovascular disease. Prog Cardiovasc Dis. 2014;56:369-81. [PMID: 24438728] doi:10.1016/j.pcad.2013.10.016 CrossrefMedlineGoogle Scholar5. Tomiyama AJ, Hunger JM, Nguyen-Cuu J, Wells C. Misclassification of cardiometabolic health when using body mass index categories in NHANES 2005-2012. Int J Obes (Lond). 2016;40:883-6. [PMID: 26841729] doi:10.1038/ijo.2016.17 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Centers for Disease Control and Prevention, Atlanta, Georgia.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L16-0407. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMetabolically Healthy Obesity and Development of Chronic Kidney Disease Yoosoo Chang , Seungho Ryu , Yuni Choi , Yiyi Zhang , Juhee Cho , Min-Jung Kwon , Young Youl Hyun , Kyu-Beck Lee , Hyang Kim , Hyun-Suk Jung , Kyung Eun Yun , Jiin Ahn , Sanjay Rampal , Di Zhao , Byung-Seong Suh , Eun Cheol Chung , Hocheol Shin , Roberto Pastor-Barriuso , and Eliseo Guallar Metabolically Healthy Obesity and Development of Chronic Kidney Disease Fatima Cody Stanford and W. Scott Butsch Metabolically Healthy Obesity and Development of Chronic Kidney Disease Dustin J. Little , Wondaye T. Deressa , Maura A. Watson , and Christina M. Yuan Metabolically Healthy Obesity and Development of Chronic Kidney Disease Yoosoo Chang , Seungho Ryu , Juhee Cho , Roberto Pastor-Barriuso , and Eliseo Guallar Metrics 15 November 2016Volume 165, Issue 10Page: 743KeywordsAdipose tissueBody mass indexEstimated glomerular filtration rateExerciseFatsLongitudinal studiesMuscle tissueMusclesObesityRisk management ePublished: 15 November 2016 Issue Published: 15 November 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...