tbuckley/cabot-search huggingface dataset:
Role of platelet-activating factor in hypotension and platelet activation induced by infusion of thrombolytic agents in rabbits.
Authors: GMontrucchio, GAlloatti, FMariano, ELupia, P GLucchina, EMusso, GEmanuelli, GCamussi
Journal: Circulation Research (1993)

Infusion of the thrombolytic agents streptokinase (SK, 666 units/kg per minute for 60 minutes) and tissue-type plasminogen activator (t-PA, 10 micrograms/kg per minute for 15 minutes) in rabbits induced a significant hypotension and decrease in platelet count that were completely prevented by treatment with platelet-activating factor (PAF) receptor antagonists SDZ 63-675 and WEB 2170. PAF synthesis by vascular tissue was suggested by its extraction from blood-free heart and aorta of rabbits treated in vivo with SK or t-PA but not of control rabbits. In contrast, PAF was not detected in peripheral blood. Ex vivo studies on platelet aggregation response to ADP and PAF performed on platelet-rich plasma obtained before and after SK and t-PA infusion demonstrated an early hyperaggregable phase, abrogated by PAF receptor antagonists and followed by reduced sensitivity of platelets to PAF. The ED50 values for the aggregation of washed rabbit platelets induced by PAF but not thrombin were significantly increased ...
Minor Papilla Sphincterotomy And Biodegradable Pancreatic Stent In The Management Of Pancreas Divisum With Recurrent Pancreatitis In A Patient
Authors: J Espinel, E Pinedo, V Cano, R Pérez, M Jiménez
Journal: Endoscopy (2021)

Endoscopic therapeutic papilla minor intervention (sphincterotomy/stenting) is challenging and reserved for patients with recurrent pancreatitis. We report our experience in an 80-year-old man with symptomatic Pancreas Divisum (10 previous episodes of acute pancreatitis). It is shown images of the cannulation technique, minor papilla sphincterotomy, placement of a new biodegradable stent, and finally, mucosal tattooing close to the minor papilla. The intervention was made successfully. So far, we have not found other publications using this biodegradable stent for that purpose. This stent could achieve to reduce post-ERCP pancreatitis and restenosis rate, keep the minor papilla open, and avoid removing the stent.
Inotropic actions of isoproterenol in cat ventricular muscle. Effects of extracellular potassium.
Authors: J RWiggins
Journal: Circulation Research (1981)

The inotropic actions of isoproterenol in cat papillary muscles or trabeculae bathed in a salt solution containing 4 mM KCl were compared to those in similar muscles bathed in a salt solution containing 22 mM KC1. Although isoproterenol evoked the same increase in force of contraction in both groups of muscles, the time course of contraction differed markedly. In muscles bathed in 4 mM KC1, isoproterenol caused a concentration-dependent decrease in time-to-peak force, but in muscles bathed in 22 mM KCl, isoproterenol caused a concentration-dependent increase in time-to-peak force. These data suggest that ventricular muscle activated by slow response action potentials may utilize a different mechanism of excitation-contraction coupling than do muscles activated by Na-dependent action potentials.
Singlet oxygen interaction with Ca(2+)-ATPase of cardiac sarcoplasmic reticulum.
Authors: R CKukreja, A AKearns, J LZweier, PKuppusamy, M LHess
Journal: Circulation Research (1991)

We investigated the role of singlet oxygen (generated from photoactivation of rose bengal) on the calcium transport and Ca(2+)-ATPase activity of cardiac sarcoplasmic reticulum (SR). Isolated cardiac SR exposed to rose bengal (10 nM) irradiated at 560 nm resulted in significant inhibition of Ca2+ uptake (from 2.27 +/- 0.05 to 0.62 +/- 0.05 mumol Ca2+/mg.min [mean +/- SEM], p less than 0.01) and Ca(2+)-ATPase activity (from 2.08 +/- 0.05 to 0.28 +/- 0.04 mumol Pi/min.mg [mean +/- SEM], p less than 0.01). The inhibition of calcium uptake and Ca(2+)-ATPase activity by rose bengal-derived activated oxygen (singlet oxygen) was dependent on the duration of exposure and intensity of light. Singlet oxygen scavengers ascorbic acid and histidine significantly protected SR Ca(2+)-ATPase against rose bengal-derived activated oxygen species, but superoxide dismutase and catalase did not attenuate the inhibition. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of SR exposed to photoactivated rose bengal for u...
Differential impairment of vasodilator responsiveness of peripheral resistance and conduit vessels in humans with atherosclerosis.
Authors: J KLiao, M ABettmann, TSandor, J ITucker, S MColeman, M ACreager
Journal: Circulation Research (1991)

The purpose of this study was to assess the effect of atherosclerosis on the regulation of limb blood flow. To examine this issue, the reactivity of resistance and conduit vessels was evaluated in 11 patients with peripheral atherosclerotic disease and six control subjects. Responsiveness of resistance vessels was measured by venous occlusion plethysmography. Responsiveness of conduit vessels was determined by quantitative angiography to measure the diameter of the superficial femoral artery. To distinguish endothelium-dependent vasodilation from that caused by direct smooth muscle relaxation, each participant received intra-arterial infusions of methacholine and nitroprusside, respectively. Flow-mediated dilation of the superficial femoral artery was determined during reactive hyperemia. Vasoconstrictor function was determined by the infusion of phenylephrine. Methacholine reduced calf vascular resistance in the control subjects but not in the patients with atherosclerosis (-64 +/- 11% versus 6 +/- 18%, ...
124P KRAS mutated (mt) non-small cell lung cancer (NSCLC) and response to antiPD-1/PD-L1 regarding co-mutational status and assessment of KRAS mutation on plasma or tissue biopsy
Authors: E. Corral de la Fuente, J.J. Soto Castillo, A. Gómez Rueda, Y. Lage, M.E. Olmedo García, E.M. Vida Navas, J. Torres Jiménez, P. Álvarez Ballesteros, M. Lario, A. Benito Berlinches, P. Garrido Lopez
Journal: Journal of Thoracic Oncology (2021)
Inadvertent toxic drug reaction in the management of atrial fibrillation
Authors: O. Jolobe
Journal: Journal of the Royal Society of Medicine (2006)

The choice of either sotalol or amiodarone for rhythm control was a feature of the management of a case presented by Leaver and Ho (March 2006 JRSM1) which was even more problematic than the inadvertent choice of adversely interacting drugs. Although amiodarone was the final choice of antiarrhythmic agent, presumably because of its superior efficacy in preventing relapse of atrial fibrillation (AF),2 it is a drug now known to be associated with relapse rates of the order of >90%.3,4 Accordingly, so long as the long-term antiarrhythmic management of AF involves drugs, which are not strikingly superior to amiodarone in their efficacy—even with the benefit of adjunctive electrical cardio-version3—the verdict from the AFFIRM study5 will prevail. In paraphrase, the verdict from AFFIRM is that failed rhythm control is a poor substitute for successful rate control.
Sodium selenite suppresses intestinal carcinogenesis in Muc-2 knockout mice and colorectal cancer cells
Authors: Wenfeng Fang, Anjia Han, Ashley Dockendorff, Lindsay Gallagher, Xiuli Bi, Dong Hu, Anna Velcich, Wancai Yang
Journal: Cancer Research (2008)

LB-322  Epidemiological and clinical studies suggest that the increased intake of dietary selenium significantly reduced overall cancer risk, the effect was most pronounced in gastrointestinal and prostate cancers; and that lower peripheral serum selenium level also increased cancer risk. To elucidate anti-cancer mechanisms of selenium, we fed the Muc-2 knockout mice with selenium-enriched (sodium selenite) diet for 24 weeks and treated human colorectal cancer cell lines HCT116 and SW620 with sodium selenite at different concentration and variant periods, respectively. First, we found that the western style diet (high fat and low calcium and vitamin D) modulated intestinal tumor formation, but selenium significantly prevented intestinal tumorigenesis in the Muc2-/- mice. In comparison with the mice fed AIN-76A control diet, intestinal tumor frequency was increased in the mice fed western-style diet (1.93 vs. 4.31, p
Eus-Guided Gastroenterostomy (EUS-GE) For Gastric Outlet Obstruction (GOO) With A Lumen-Apposing Metal Stent (LAMS): Prospective Multicenter Procedural Standardization Of The Parallel Enteral Catheter (PEC) Method
Authors: C Chavarría, V Martín-Álvarez, JR Aparicio, JC Subtil, FJ Garcia Alonso, JJ Vila, B Martínez-Moreno, V Busto Bea, C de la Serna-Higuera, M Perez-Miranda
Journal: Endoscopy (2021)

Aims Several EUS-GE techniques are available. Fluid instillation into the small bowel using a nasobiliary drain as a PEC during transgastric LAMS insertion under EUS is simple but not yet standardized. We aimed at standardizing the PEC method for EUS-GE.
CHEERS Reporting Guidelines for Economic Evaluations
Authors: Oluwadamilola M. Fayanju, Jason S. Haukoos, Jennifer F. Tseng
Journal: JAMA Surgery (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Palbociclib demonstrates intracranial activity in progressive brain metastases harboring cyclin-dependent kinase pathway alterations
Authors: Priscilla K. Brastianos, Albert E. Kim, Nancy Wang, Eudocia Q. Lee, Jennifer Ligibel, Justine V. Cohen, Ugonma N. Chukwueke, Maura Mahar, Kevin Oh, Michael D. White, Helen A. Shih, Deborah Forst, Justin F. Gainor, Rebecca S. Heist, Elizabeth R. Gerstner, Tracy T. Batchelor, Donald Lawrence, David P. Ryan, A. John Iafrate, Anita Giobbie-Hurder, Sandro Santagata, Scott L. Carter, Daniel P. Cahill, Ryan J. Sullivan
Journal: Nature Cancer (2021)
Significance of systemic vascular resistance in determining the hemodynamic effects of hydralazine on large ventricular septal defects.
Authors: MNakazawa, ATakao, YChon, TShimizu, MKanaya, KMomma
Journal: Circulation (1983)

The hemodynamic effects of hydralazine were studied in 17 infants and young children with ventricular septal defects to clarify the significance of systemic vascular resistance (SVR) in determining these effects. Patients with peak pulmonary arterial pressures greater than 75% of systemic pressure were placed in group I, which was further divided into group Ia (n = 6), consisting of those with a control SVR of 20 U.m2 or higher, and group Ib (n = 8), consisting of those with a lower SVR. Group II consisted of three patients with lower pulmonary arterial pressures. Intravenous injection of hydralazine (0.3 mg/kg) reduced SVR in all but two patients. The magnitude of reduction correlated with prehydralazine (control) SVR (r = .66, p less than .01). Systemic blood flow (Qs) increased from 3.7 +/- 0.7 to 5.0 +/- 0.8 l/min/m2 (p less than .005). The mean systemic arterial pressure for all patients decreased from 69 +/- 2 to 65 +/- 2 mm Hg (p less than .01) and the mean pulmonary arterial pressure decreased fro...
Abstract 14644: Hemoglobin A1c Carries Independent Mortality Risk in U.s. Veterans With Vascular Risk Factors
Authors: Swapnil Garg, Muhammad Soofi, Ronald Markert, Ajay Agarwal
Journal: Circulation (2020)

Background: Large epidemiologic studies have established diabetes mellitus as an independent risk factor for all-cause mortality. There is also evidence to suggest a linear relationship between hemoglobin A1c (HbA1c) and mortality. We find that poorly controlled diabetes in high-risk US Veterans carries an independent mortality risk mediated through reduced ejection fraction (rEF) and obstructive coronary artery disease (ObCAD). Methods: 1535 consecutive US Veterans presenting for left heart catheterization were retrospectively analyzed for presence of risk factors with long-term follow-up. Results: 248 patients had HbA1c ≥8 with 76.2% mortality compared to 198 patients with HbA1c in the prediabetic range of 5.70-6.49 with 67.2% mortality (p = 0.03) with univariate hazard ratio (HR) 1.25 [1.002-1.56, p=0.048]. Multivariate adjustment for age, BMI, hypertension, hyperlipidemia, chronic kidney disease yielded HR 1.28 [1.02-1.60, p=0.034]. Multivariate adjustment for aforementioned variables with addition of rEF, ObCAD and prior revascularization yielded HR 1.17 [0.93-1.48, p=0.19]. Conclusion: We conclude that poorly controlled diabetes with HbA1c 8 or greater carries independent mortality risk when controlled for traditional risk factors however loses significance after controlling for rEF, ObCAD and prior revascularization.
Early detection of myocardial infarction in conscious dogs by analysis of plasma MM creatine kinase isoforms.
Authors: HHashimoto, D RAbendschein, A WStrauss, B ESobel
Journal: Circulation (1985)

To determine whether myocardial infarction could be detected early after onset by analysis of subforms of the MM isoenzyme (isoforms) of creatine kinase (MM CK) in plasma, we subjected eight conscious dogs to coronary occlusion and quantified isoforms in serial plasma samples by chromatofocusing. The fractions of MMA (isoelectric point [pI] = 7.91), MMB (pI = 7.74), and MMC (pI = 7.51) in plasma samples before coronary occlusion averaged 11.4 +/- 4.8% (SD), 22.3 +/- 5.5%, and 66.3 +/- 9.6% of total MM CK activity. The fraction of MMA, the isoform of MM CK found in myocardium, increased significantly in plasma 1 hr after coronary occlusion, reached a maximum of 49.7 +/- 8.0% in 4.1 +/- 1.3 hr, and returned to baseline in 12.0 +/- 2.3 hr. The fraction of plasma MM CK activity attributable to MMC, an isoform formed slowly in plasma from MMA via MMB as an intermediate, decreased significantly within 1 hr, reached a minimum of 14.0 +/- 4.1% in 4.8 +/- 1.1 hr, and returned to baseline in 13.0 +/- 2.9 hr after c...
Shall The Journal be Removed to Washington?
Authors: E. Griswold
Journal: JAMA (1891)

<h3>To the Editor:</h3> —The arguments<i>for removal</i>are: 1. OurJournalhas a name distinctive of its nationality, and inasmuch as it represents, or is intended to represent the status of the medical profession of this country, it would seem as if its seat ought to be at the Capital, which, though not the geographical centre, is really the<i>centre</i>from which our whole system of National economy radiates. 2. The Library of the Association and the ever increasing National Library, and the Army Medical Museum are there, and always at hand for the use of the editorial department. 3. The Army, Navy and Marine-Hospital medical and surgical news are there and easily available. 4. National pride may say to many: "Place the National Journal in the National Capital." <h3>Against removal:</h3> 1.The Journal, although born in Cleveland, O., was immediately taken to Chicago, where it was carefully nurtured during
Production of left ventricular cavitary obliteration in normal man.
Authors: RGrose, CMaskin, HSpindola-Franco, TYipintsoi
Journal: Circulation (1981)

To determine whether left ventricular cavitary obliteration (a finding previously described only in hypertrophic states) can be induced in normal subjects, 16 patients without coronary artery disease or clinical evidence of hypertrophic obstructive cardiomyopathy were studied during cardiac catheterization. Resting left ventricular and aortic pressures and left ventriculography were repeated during the strain phase of Valsalva maneuver after administration of amyl nitrite. Cavitary obliteration during normal sinus rhythm was defined as disappearance of the sinus portion of the left ventricle during systole, and graded as absent, partial or total. Patients were placed into two groups on the basis of qualitative analysis of the resting left ventriculogram: the 10 patients in group A had normal left ventriculograms and the six patients in group B had hyperkinetic left ventricles. During the left ventriculogram done with amyl nitrite and Valsalva, left ventricular volumes in both decreased dramatically, from ...
Active and passive immunization against angiotensin II in the rat and rabbit. Evidence for a normal regulation of the renin-angiotensin system.
Authors: HBauknecht, EHackenthal
Journal: Circulation Research (1975)

Active or passive immunization has been used repeatedly as a tool in studies on the role of the renin-angiotensin system in the control of blood pressure and kidney function. The results are not consistent among each other, and they are also at variance with other studies using different approaches. To evaluate the possible causes of these discrepancies, the biological characteristics of angiotensin antibodies were studied in rats. Following the intravenous injection of angiotensin II antibodies (purified by affinity chromatography), the plasma concentration of the antibodies declined in a two-exponential curve with half times of 11 hours and 7 days, which probably reflect distribution in the extracellular space and elimination, respectively. Plasma angiotensin II levels rose from preinjection levels of 100 pg/ml to 12,000 pg/ml within 10 minutes and then declined concomitantly with the decline in antibody concentration. We calculated that only a samll fraction of the circulating antibody was occupied by ...
Analysis of secondary pauses following termination of rapid atrial pacing in man.
Authors: D GBenditt, H CStrauss, M MScheinman, V SBehar, A GWallace
Journal: Circulation (1976)

The first ten cycles following cessation of atrial pacing were evaluated in 44 control subjects (mean age 52.9 +/- 14.88 yr) and 39 patients (mean age 62.9 +/- 15.41 yr) suspected of having sinus node dysfunction (SND). The maximal cycle length for each postpacing cycle following several pacing periods in each control subject was determined, and was normalized by dividing it by the subject's mean spontaneous control cycle length (SCL). Using the control group, a normalized maximal post-pacing response pattern (mean and SD) was derived. For each SND patient, a composite SD for each post-pacing cycle was calculated by adding the patient's SCL variance to the variance determined for each post-pacing cycle in the control group. Two composite SD above the mean value for each post-pacing cycle was selected as the upper limit of the normal recovery response and used to identify abnormal post-pacing responses in the 39 SND patients. Abnormally prolonged cycle lengths subsequent to the first escape cycle (secondar...
Shall The Journal be Removed to Washington?
Authors: C. D. Owens
Journal: JAMA (1891)

<h3>To the Editor:</h3> —As a member of the Association, I have carefully read and compared the various reasons assigned for the removal ofThe Journal, or for continuing its publication in Chicago, wishing, in casting my vote, to do so only after mature consideration. It would occupy too great space to review the pros and cons—the arguments offered on both sides of the question—those of Dr. Solis-Cohen's removal article, so ably replied to by Harold N. Moyer, M.D., and Harvey Reed, M.D.; the spicy and patriotic non-removal vote of E. Chenery, M.D.; besides various other articles appearing inThe Journalunder the heading: " ShallThe Journal, be Removed to Washington?" Permit me, on so appropriate an occasion, to offer the tribute of my sincere esteem to Dr. E. Chenery, for the display of such unbiased and patriotic sentiments as expressed in his letter toThe Journalof January 27. Certainly,
Force-velocity characteristics and active tension in relation to content and orientation of smooth muscle cells in aortas from normotensive and spontaneous hypertensive rats.
Authors: AArner, BUvelius
Journal: Circulation Research (1982)

Segments of abdominal aorta from spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats (20-25 weeks) were compared with respect to force production and dynamic mechanical properties. The preparations were mounted in vitro for determination of optimal length (lo) for active force, and then maximally stimulated (high-K+ solution, 10 mm Ca2+, 10(-5) m noradrenaline), and fixed for electron microscopy. Muscle cellular volume per mm vessel wall was significantly (p less than 0.01) higher in SHR (0.14 +/- 0.009 mm3, n = 7) compared to WKY (0.11 +/- 0.004 mm3, n = 7). Unchanged cell length and unaltered cross-sectional area (17 micrometers2) of nucleus containing cell profiles in SHR suggest an increased number of cells in the media. No difference was found in maximum force per unit cell area between SHR (271 +/- 31, n = 7) and WKY (305 +/- 49 mN/mm2, n = 7). Cell orientation was almost circular in both groups, showing that force was measured in parallel to the cell long axis. Aortic segments...
Effects of intensive multiple risk factor reduction on coronary atherosclerosis and clinical cardiac events in men and women with coronary artery disease. The Stanford Coronary Risk Intervention Project (SCRIP).
Authors: W LHaskell, E LAlderman, J MFair, D JMaron, S FMackey, H RSuperko, P TWilliams, I MJohnstone, M AChampagne, R MKrauss
Journal: Circulation (1994)

BACKGROUNDRecent clinical trials have shown that modification of plasma lipoprotein concentrations can favorably alter progression of coronary atherosclerosis, but no data exist on the effects of a comprehensive program of risk reduction involving both changes in lifestyle and medications. This study tested the hypothesis that intensive multiple risk factor reduction over 4 years would significantly reduce the rate of progression of atherosclerosis in the coronary arteries of men and women compared with subjects randomly assigned to the usual care of their physician.METHODS AND RESULTSThree hundred men (n = 259) and women (n = 41) (mean age, 56 +/- 7.4 years) with angiographically defined coronary atherosclerosis were randomly assigned to usual care (n = 155) or multifactor risk reduction (n = 145). Patients assigned to risk reduction were provided individualized programs involving a low-fat and -cholesterol diet, exercise, weight loss, smoking cessation, and medications to favorably alter lipoprotein pro...
Comparison of the Generation of Pancreatic Cancer Patient-Derived Organoids by Endoscopic Ultrasound-Guided fine Needle Aspirations and fine Needle Biopsies
Authors: JR Wiessner, F Orben, A Schäfer, L Fricke, A Herner, U Mayr, V Phillip, M Treiber, G von Figura, M Abdelhafez, Schmid RM, G Schneider, M Reichert, C Schlag
Journal: Endoscopy (2021)

Aims The prognosis for pancreatic cancer remains poor. Molecular diagnostics and customized therapies are becoming increasingly important in clinical routine. Patient-derived, predictive model systems such as organoids of endoscopic ultrasound (EUS)-guided punctures have the potential to substantially increase the depth of information from biopsy material by functional and molecular characterization of pancreatic cancer-patient derived organoids (PDOs). Improving the take rate of these organoids is a key step to bring this technology into routine clinical diagnostics.