tbuckley/cabot-search huggingface dataset:
Feasibility and Therapeutic Potential of Peptide Receptor Radionuclide Therapy for High-Grade Gliomas
Authors: Reza Nemati, Hossein Shooli, Seyed Javad Rekabpour, Hojjat Ahmadzadehfar, Esmail Jafari, Mohammad Reza Ravanbod, AbdolLatif Amini, Ali Nemati, Mohammad Ghasemi, Saeid Keshmiri, Habibollah Dadgar, Majid Assadi
Journal: Clinical Nuclear Medicine (2021)

Purpose This pilot study tested the principle that 177 Lu-DOTATATE may be applied to patients with high-grade gliomas (HGGs) that are either inoperable or refractory to the standard conventional treatments and also assessed whether this approach could be a viable therapeutic plan in this dilemma. Methods In this prospective study, 16 subjects experiencing HGGs that were either inoperable or refractory to the standard conventional treatments were included. All the patients checked for somatostatin receptor expression on the tumors. The patients were treated with 1 to 4 cycles of IV 177 Lu-DOTATATE. The primary end point was radiological response after peptide receptor radionuclide therapy, and the secondary end point was improved quality of life using Karnofsky Performance Score and Eastern Cooperative Oncology Group score. Results In total, 16 subjects (10 males and 6 females) with a mean age of 55.68 ± 13.17 years (26–73 years) participated in the study. Of them, 8 patients were new HGG cases, and 8 patients had recurrent tumors. The participants’ responses to treatments were complete remission in 12.5% of (n = 2), partial remission in 31.25% (n = 5), disease stability in 18.7% (n = 3), and disease progression in 37.5% (n = 6). In total, pretreatment and posttreatment Karnofsky Performance Score and Eastern Cooperative Oncology Group scores did not improved ( P &gt; 0.05). The patients were followed up from 1 month to 26 months (median, 3 months). Conclusions This preliminary result suggests that peptide receptor radionuclide therapy using 177 Lu-DOTATATE may be associated with positive effects in patients with HGGs (grade III–IV). However, this approach should be evaluated in a more homogeneous group of patients with more favorable performance status.
Abstract 17770: Limited Efficacy of Rotational Atherectomy to Calcified Coronary Artery Lesion in Patients with Kawasaki Disease; Relatively High Rate of Restenosis and Adverse Cardiac Events
Authors: Takeshi Yagyu, Hiroki Sakamoto, Fujino Masashi, Leon Kumasaka, Takafumi Yamane, Taichi Adachi, Tetsuo Arakawa, Yasuhide Asaumi, Tadayoshi Miyagi, Jun-ichi Kotani, Teruo Noguchi, Etsuko Tsuda, Osamu Yamada, Toshihisa Anzai, Masaharu Ishihara, Wataru Shimizu, Isao Shiraishi, Hisao Ogawa, Satoshi Yasuda
Journal: Circulation (2012)

Background: Kawasaki disease(KD) has become the most prevalent acquired cardiac disease in children in developed countries. Although recent studies have demonstrated excellent long-term outcomes of...
Correction: Association of FGFR1 with ERα Maintains Ligand-Independent ER Transcription and Mediates Resistance to Estrogen Deprivation in ER+ Breast Cancer
Authors: Luigi Formisano, Kimberly M. Stauffer, Christian D. Young, Neil E. Bhola, Angel L. Guerrero-Zotano, Valerie M. Jansen, Mónica M. Estrada, Katherine E. Hutchinson, Jennifer M. Giltnane, Luis J. Schwarz, Yao Lu, Justin M. Balko, Olivier Deas, Stefano Cairo, Jean-Gabriel Judde, Ingrid A. Mayer, Melinda Sanders, Teresa C. Dugger, Roberto Bianco, Thomas Stricker, Carlos L. Arteaga
Journal: Clinical Cancer Research (2019)
Evidence of impaired left ventricular performance after an uninterrupted competitive 24 hour run.
Authors: K ONiemelä, I JPalatsi, M JIkäheimo, J TTakkunen, J JVuori
Journal: Circulation (1984)

The effect of extremely exhaustive exercise on left ventricular performance was studied echocardiographically in 13 experienced male ultramarathon runners who took part in a competitive 24 hr run, completing distances of 114 to 227 km. Although the left ventricular end-diastolic dimension (EDD) was reduced by 7% (54 +/- 5 to 50 +/- 7 mm; p less than .005), the end-systolic dimension (ESD) increased slightly (33 +/- 5 to 34 +/- 6 mm; NS). As a consequence, the stroke dimension (21 +/- 2 to 16 +/- 2 mm; p less than .005) and fractional shortening (38 +/- 5% to 32 +/- 5%; p less than .005) declined by 24% and 16%, respectively. The reduction in fractional shortening was related to delta ESD (r = -.66; p less than .05) but not to delta EDD (r = .22; NS). In spite of reduced afterload, the mean velocity of circumferential fiber shortening also decreased by an average of 9% (p less than .01) in proportion to the distance completed (r = -.69; p less than .01). The systolic blood pressure/ESD ratio was 21% lower ...
Electrophysiological evaluation of the Wolff-Parkinson-White syndrome: problems in assessing antegrade and retrograde conduction over the accessory pathway.
Authors: R HSvenson, H CMiller, J JGallagher, A GWallace
Journal: Circulation (1975)

The effect of atrial pacing and recording site and ventricular pacing site on assessment of conduction over the accessory pathway (AP) was examined in a group of patients with the Wolff-Parkinson-White syndrome. The importance of initial localization of the AP by recording the sequence of retrograde atrial activation during circus movement tachycardia is demonstrated. Inability to record or pace near the AP may lead to significant errors in the assessment of the antegrade and retograde conduction properties of the AP. During ventricular pacing, retrograde atrial fusion was consistently demonstrated with laterally located APs.
Endothelin 1 enhances myofilament Ca2+ responsiveness in aequorin-loaded ferret myocardium.
Authors: J XWang, GPaik, J PMorgan
Journal: Circulation Research (1991)

The influence of endothelin 1 on intracellular Ca2+ transients and isometric contractions was investigated in ferret papillary muscles loaded with the Ca(2+)-regulated bioluminescent indicator aequorin. In concentrations of 3 x 10(-9) to 1 x 10(-7) M, endothelin produced dose-dependent increases in the amplitudes of both aequorin light signals (maximum, 31 +/- 12%) and developed tension (maximum, 64 +/- 13%). The peak aequorin light [( Ca2+]i)-peak tension curve generated by increasing endothelin concentrations was steeper and shifted to the left of the curve generated by varying [Ca2+]o; however, the maximum developed tension produced by endothelin did not exceed that produced by 6 mM [Ca2+]o. The effect of endothelin on the amplitude of the aequorin light signal was less than the effect of [Ca2+]o for similar levels of tension development. Moreover, 1 x 10(-7) M endothelin caused an upward shift in the peak aequorin light-peak tension curve generated by varying [Ca2+]o and increased the maximum twitch f...
Delayed effects of early infarct-limiting therapies on healing after myocardial infarction.
Authors: B IJugdutt
Journal: Circulation (1985)

The effect of early infarct-limiting therapy on the hydroxypyroline (OHP, a marker of collagen) content and topography of 7-day-old infarcts was studied in 76 conscious dogs (69 ligated; seven sham operated). Two hours after their left anterior descending coronary arteries were occluded, 69 dogs were randomly assigned to receive 6 hr intravenous infusions of saline (controls; n = 29), low-dose nitroglycerin (NG; n = 13), prostacyclin (PGI2; n = 14), or ibuprofen (IBU; n = 13). Regional OHP (mg/g dry weight) was measured by spectrophotometry, and size of infarction and topography were determined by computerized planimetry. Infarct size was less in the NG, PGI2, and IBU groups compared with that in the saline group, both when measured as a percent of the arteriographic occluded bed (p less than .001) and as a percent of the left ventricle (p less than .005). For each treatment group (1) the level of OHP was higher (p less than .001) in the region of infarction (saline group, 9.9 +/- 0.7 mg/g; NG group, 14.9...
Correlation of echocardiographic wall stress and left ventricular pressure and function in aortic stenosis.
Authors: N LDePace, J FRen, A SIskandrian, M NKotler, A HHakki, B LSegal
Journal: Circulation (1983)

Previous studies have suggested that left ventricular pressure (P) can be predicted in patients with aortic stenosis by the equation P = 235 h/r, where 235 is a constant peak wall stress (sigma), h is end-systolic wall thickness, and r is end-systolic dimension/2; h and r are measured by M-mode echocardiography. In 73 patients with aortic stenosis (valve area less than 0.7 cm2), measured and predicted left ventricular pressure correlated poorly (r = 0.17). The measured wall stress in our patients varied from 120 to 250 mm Hg in patients with normal left ventricular function and from 250 to 550 mm Hg in patients with abnormal function. The correlation between sigma and h was only fair (r = 0.53), because many patients had inappropriate left ventricular hypertrophy. There was a statistically significant correlation between ejection fraction and sigma (r = 0.62) and between ejection fraction and end-systolic dimension (r = -0.70), but there was considerable scatter of ejection fractions for any given end-sys...
Role of hydrostatic and oncotic pressures in renal sodium reabsorption.
Authors: F GKnox, J IMertz, J CBurnett, AHaramati
Journal: Circulation Research (1983)

Physical factors, and renal interstitial hydrostatic pressure in particular, have an important effect on sodium excretion by the kidney. Changes in hydrostatic and oncotic pressures in the peritubular microcirculation may have effects on proximal tubule reabsorption under some, but not all, circumstances. In regard to control of sodium excretion, the loop of Henle may be a particularly important segment which is sensitive to transepithelial hydrostatic pressure changes. There is little evidence to support an effect of physical factors on sodium reabsorption by the distal tubule. The collecting tubule may be another pressure-sensitive site; however, changes in sodium reabsorption by deep nephrons in the kidney may account for changes that have been attributed to the collecting duct. Changes in intrarenal pressure may be an important link in the regulation of sodium excretion, particularly in pathological circumstances, such as the exaggerated natriuresis of hypertension and the sodium retention seen in con...
Cardiac sympathetic nervous activity in congestive heart failure. Evidence for increased neuronal norepinephrine release and preserved neuronal uptake.
Authors: I TMeredith, GEisenhofer, G WLambert, E MDewar, G LJennings, M DEsler
Journal: Circulation (1993)

BACKGROUNDIncreased concentrations of norepinephrine in coronary sinus plasma reported in congestive heart failure (CHF) could result from increased cardiac sympathetic nerve firing and norepinephrine release or from failure of neuronal uptake mechanisms to recapture released norepinephrine. We have applied neurochemical indexes of cardiac sympathetic nerve function in heart failure patients to delineate the underlying neural pathophysiology.METHODS AND RESULTSCardiac norepinephrine synthesis, assessed from the cardiac overflow of the norepinephrine precursor dihydroxyphenylalanine (DOPA), intraneuronal metabolism estimated from the overflow of the intraneuronal metabolite dihydroxyphenylglycol (DHPG), neuronal norepinephrine reuptake assessed from the fractional extraction of plasma-tritiated norepinephrine and production of tritiated DHPG across the heart, and norepinephrine spillover to plasma were examined in eight patients with CHF caused by coronary artery disease (left ventricular ejection fraction...
Starling resistor versus compliance. Which explains the zero-flow pressure of a dynamic arterial pressure-flow relation?
Authors: SMagder
Journal: Circulation Research (1990)

Arterial pressure at zero flow (Pz = 0) that is higher than venous pressure (Pv) in dynamic pressure-flow relations has been explained by the presence of an arteriolar Starling resistor (SR) mechanism (i.e., vascular waterfall) or the discharge of vascular capacitance. To determine which was predominant, I studied in vivo hind limbs of 18 anesthetized dogs in which femoral arteries were cannulated with in-line electromagnetic flow probes to measure inflow (Qin), Pv was controlled, and collateral flow was eliminated with a tourniquet. Pz = 0 was obtained by turning flow to zero. Three tests were applied: 1) Pv was raised in steps with either constant Qin or constant arterial pressure (Pa) to determine the pressure at which upstream vascular characteristics were affected by a change in Pv, 2) the time to reach Pz = 0 was varied to determine compliance effects, and 3) an equation was developed to determine if experimentally derived parameters could explain Pz = 0 without invoking an SR. With constant Qin and...
Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant
Authors: Carl Graham, Jeffrey Seow, Isabella Huettner, Hataf Khan, Neophytos Kouphou, Sam Acors, Helena Winstone, Suzanne Pickering, Rui Pedro Galao, Liane Dupont, Maria Jose Lista, Jose M. Jimenez-Guardeño, Adam G. Laing, Yin Wu, Magdalene Joseph, Luke Muir, Marit J. van Gils, Weng M. Ng, Helen M.E. Duyvesteyn, Yuguang Zhao, Thomas A. Bowden, Manu Shankar-Hari, Annachiara Rosa, Peter Cherepanov, Laura E. McCoy, Adrian C. Hayday, Stuart J.D. Neil, Michael H. Malim, Katie J. Doores
Journal: Immunity (2021)

Interaction of the SARS-CoV-2 Spike receptor binding domain (RBD) with the receptor ACE2 on host cells is essential for viral entry. RBD is the dominant target for neutralizing antibodies, and several neutralizing epitopes on RBD have been molecularly characterized. Analysis of circulating SARS-CoV-2 variants has revealed mutations arising in the RBD, N-terminal domain (NTD) and S2 subunits of Spike. To understand how these mutations affect Spike antigenicity, we isolated and characterized >100 monoclonal antibodies targeting epitopes on RBD, NTD, and S2 from SARS-CoV-2-infected individuals. Approximately 45% showed neutralizing activity, of which ∼20% were NTD specific. NTD-specific antibodies formed two distinct groups: the first was highly potent against infectious virus, whereas the second was less potent and displayed glycan-dependant neutralization activity. Mutations present in B.1.1.7 Spike frequently conferred neutralization resistance to NTD-specific antibodies. This work demonstrates that neutralizing antibodies targeting subdominant epitopes should be considered when investigating antigenic drift in emerging variants.
Proximal coronary vasomotor reactivity after exercise training in dogs.
Authors: A ABove, J DDewey
Journal: Circulation (1985)

The effects of exercise on large coronary vasoreactivity were determined in eight dogs trained by treadmill running for 8 weeks. Six nontrained dogs comprised the control group. The trained group showed a significant reduction in heart rate during graded submaximal exercise testing when compared with the controls, and resting plasma levels of norepinephrine (nontrained group, 331 +/- 99 pg/ml; trained group, 142 +/- 30 pg/ml; p less than .05) and epinephrine (nontrained, 424 +/- 105; trained, 258 +/- 45 pg/ml; p less than .05) were reduced significantly in the trained group. Epicardial coronary responses to intracoronary infusion of serotonin and phenylephrine were evaluated by quantitative coronary angiography, and myocardial blood flow was measured with 15 microns radioactive microspheres. Left ventricular/body weight ratio was similar in the trained (4.81 +/- 0.24 g/kg) and nontrained groups (4.79 +/- 0.17), and no differences were noted in resting myocardial oxygen consumption or coronary arteriovenou...
From the authors:
Authors: M. Humbert, O. Sitbon, D. Montani, X. Jaïs, A. Yaïci, D.S. O'Callaghan, R. Souza, G. Simonneau
Journal: European Respiratory Journal (2011)

anorexigen-associated PAH.We would explain this observation by the substantial delay in the start of targeted PAH therapy in the prevalent cohort.This is confirmed by the prevalent patients showing more advanced disease as measured by invasive haemodynamics at the time of inclusion, as well as a trend towards reduced peak oxygen uptake.This observation is in agreement with data suggesting that patients suffer irreversible progression of disease if targeted therapy is delayed [2,3].Our data on the prognosis of incident patients also confirms previous survival data reported by HOEPER et al. [4] from a single centre cohort treated with contemporary targeted PAH therapy.Even with cautious interpretation of our data, they strongly contrast with the generalised conclusions drawn by HUMBERT et al. [1] from their data.Although self-selection of sicker patients during the pre-inclusion phase in prevalent patients should result in a relative survival advantage of the remaining patients compared with incident patients [5], our data suggest that this can be offset by the beneficial effect of early institution of targeted therapy.Although comparing our data with those from HUMBERT et al.[1] is carrying some limitations, it illustrates the problem of generalising prognostic data even when obtained from a large multicentre registry.
Cytosolic calcium staircase in cultured myocardial cells.
Authors: H CLee, W TClusin
Journal: Circulation Research (1987)

To elucidate the mechanism of the tension staircase, chick embryonic myocardial cell aggregates were loaded with the fluorescent cytosolic calcium indicator, indo 1. Fluctuations in indo 1 fluorescence were compared with recordings of cell edge movement during spontaneous beating and during stimulation by intracellular current pulses. Indo 1-loaded aggregates exhibit fluorescence transients during each transmembrane action potential. The rising phase of the transients is rapid, but the decaying phase is slow (several hundred msec) and is similar in time course to the pandiastolic relaxation seen in the optical recordings of cell edge movement. Acceleration of beat frequency by brief depolarizing current pulses produces an ascending staircase in both edge movement and systolic [Ca2+]i. There is a similar staircase in the diastolic [Ca2+]i, which is also reflected by diastolic cell edge movement. The existence of a diastolic [Ca2+]i staircase may provide new insight into the mechanism of the force-frequency...
Timing Of Endoscopic Retrograde Cholangiopancreatography (ERCP) In Patients With Acute Gallstone Pancreatitis During The First Wave Of Covid-19 Pandemic, Are We Following The Guidelines!
Authors: E Gadour, M Musharaf, S Hafeez, Y Shafiq
Journal: Endoscopy (2021)

Aims: Introduction Gallstone is well known, among other aetiologies, cause of Acute pancreatitis1. It is crucial to make early diagnosis as different treatment approached is recommended which includes early ERCP and cholecystectomy2. In a proven or suspected gallstone pancreatitis, patients should undergo a therapeutic ERCP within 72 hours as per BSG guidleines3.
Microbiota engraftment after faecal microbiota transplantation in obese subjects with type 2 diabetes: a 24-week, double-blind, randomised controlled trial
Authors: Siew C Ng, Zhilu Xu, Joyce Wing Yan Mak, Keli Yang, Qin Liu, Tao Zuo, Whitney Tang, Louis Lau, Rashid N Lui, Sunny H Wong, Yee Kit Tse, Amy Y L Li, Kitty Cheung, Jessica Y L Ching, Vincent W S Wong, Alice P S Kong, Ronald C W Ma, Elaine Y K Chow, Simon K H Wong, Ivan Chak Hang Ho, Paul K S Chan, Francis K L Chan
Journal: Gut (2021)

The impact of faecal microbiota transplantation (FMT) on microbiota engraftment in patients with metabolic syndrome is uncertain. We aimed to study whether combining FMT with lifestyle modification could enhance the engraftment of favourable microbiota in obese patients with type 2 diabetes mellitus (T2DM).In this double-blind, randomised, placebo-controlled trial, 61 obese subjects with T2DM were randomly assigned to three parallel groups: FMT plus lifestyle intervention (LSI), FMT alone, or sham transplantation plus LSI every 4 weeks for up to week 12. FMT solution was prepared from six healthy lean donors. Faecal metagenomic sequencing was performed at baseline, weeks 4, 16 and 24. The primary outcome was the proportion of subjects acquiring ≥20% of microbiota from lean donors at week 24.Proportions of subjects acquiring ≥20% of lean-associated microbiota at week 24 were 100%, 88.2% and 22% in the FMT plus LSI, FMT alone, and sham plus LSI groups, respectively (p<0.0001). Repeated FMTs significantly increased the engraftment of lean-associated microbiota (p<0.05). FMT with or without LSI increased butyrate-producing bacteria. Combining LSI and FMT led to increase in Bifidobacterium and Lactobacillus compared with FMT alone (p<0.05). FMT plus LSI group had reduced total and low-density lipoprotein cholesterol and liver stiffness at week 24 compared with baseline (p<0.05).Repeated FMTs enhance the level and duration of microbiota engraftment in obese patients with T2DM. Combining lifestyle intervention with FMT led to more favourable changes in recipients' microbiota and improvement in lipid profile and liver stiffness.NCT03127696.
Failure of nifedipine and reperfusion to reduce infarct size relative to region at risk as measured by NADH fluorophotography.
Authors: EFoster, DDeJong, CConnelly, C SApstein
Journal: Circulation (1984)

In this report we describe a new technique for the measurement of region at risk after coronary artery ligation in the rabbit by NADH fluorophotography. We also describe the application of this technique to a study of nifedipine combined with reperfusion in experimental myocardial infarction. In 16 untreated rabbits the epicardial surface area of NADH fluorescence immediately after coronary ligation correlated with infarct size at 24 hr after coronary occlusion, as measured by nitro blue tetrazolium staining (r = .84, p less than .001). In 24 rabbits we studied the effect of nifedipine administered immediately after coronary ligation and combined with reperfusion at 1 hr after occlusion. Nifedipine had no significant effect on region at risk or infarct size.
Comment on Anjana et al. Incidence of Diabetes and Prediabetes and Predictors of Progression Among Asian Indians: 10-Year Follow-up of the Chennai Urban Rural Epidemiology Study (CURES). Diabetes Care 2015;38:1441–1448
Authors: Deep Dutta, Satinath Mukhopadhyay
Journal: Diabetes Care (2015)

In a cohort from Chennai, India, Anjana et al. (1) recently reported one of the highest global rates of progression of prediabetes to type 2 diabetes (T2D) (78.9 per 1,000 person-years [95% CI 68.0–90.9]). One hundred seventy-six out of 299 people with prediabetes developed T2D over a median follow-up period of 9.1 years. Advancing age, positive family history of T2D, 2-h plasma glucose, low HDL cholesterol, and physical inactivity were independent predictors of progression to T2D (1). These rates are much higher than …