tbuckley/cabot-search huggingface dataset:
The experience of treating patients with cancer during the COVID-19 pandemic in China
Authors: L. Zhang, F. Zhu, L. Xie, C. Wang, J. Wang, R. Chen, P. Jia, H. Q. Guan, L. Peng, P. Peng, P. Zhang, Q. Chu, Q. Shen, Y. Wang, S. Y. Xu, J. P. Zhao, M. Zhou, Y. Chen
Journal: Cancer Research (2020)

Background: Cancer patients are regarded as highly vulnerable group in the current SARS-CoV-2/COVID-19pandemic  Up to date, the clinical characteristics of cancer patients with COVID-19 are largely unknown  Patients and methods: In this retrospective cohort study, we collected and analyzed data of the cancer patients with y confirmed COVID-19 infection from three designated hospitals in Wuhan, China from Jan 13, 2020, to Feb 26,2020  Univariate and multivariate analyses were performed to assess the risk factors associated with severe events defined as a condition that admission to an intensive care unit, the use of mechanical ventilation, or death  We also followed 124 cancer patients with immune checkpoint inhibitors (ICI) and their families for their infection rate and clinical outcome  Results: Twenty-eight COVID-19 infected cancer patients were included with median age of 65 0 years (IQR:56 0-70 0) and male gender of 60 7% (17/28)  Amount of these 28 patients, 7 (25%) had lung cancer, and 8 (28 6%) were considered to be infected via hospital-associated transmission  Fifteen (53 6%) patients had severe events with themortality rate of 28 6%  The last anti-tumor treatment with in 14 days from the diagnoses of COVID significant increased risk of developing severe events (HR=4 079, 95%CI 1 086-15 322, P=0 037)  The common chest CTfindings were ground-glass opacity (21, 75 0%) and patchy consolidation (13, 46 3%)  The patchy consolidation onCT had a higher risk for developing severe events (HR=5 438, 95%CI 1 498-19 748, P=0 010)  There was only onepatient (1/124, 0 8%) who have been on ICI treatment for his metastatic HCC confirmed with COVID infection, and with mild clinic presentation and a short hospital course  Conclusions: Cancer patients showed aggressive presentation and poor outcomes with the COVID-19 infection  It isrecommended that vigorous screening for COVID-19 infection should be performed for cancer patients with anti-tumor  From our limited data, there is no evidence to suggest difference in cancer patients on ICI treatment
<i>Notes from the Field:</i> Vitamin D–Deficient Rickets and Severe Hypocalcemia in Infants Fed Homemade Alkaline Diet Formula — Three States, August 2020–February 2021
Authors: Diane P. Calello, Mohamed Jefri, Melissa Yu, Joseph Zarraga, David Bergamo, Richard Hamilton
Journal: MMWR Morbidity and Mortality Weekly Report (2021)
Complexity of Medication Regimens for Children With Neurological Impairment
Authors: James A. Feinstein, Hannah Friedman, Lucas E. Orth, Chris Feudtner, Allison Kempe, Sadaf Samay, Allison B. Blackmer
Journal: JAMA Network Open (2021)

Parents of children with severe neurological impairment (SNI) manage complex medication regimens (CMRs) at home, and clinicians can help support parents and simplify CMRs.To measure the complexity and potentially modifiable aspects of CMRs using the Medication Regimen Complexity Index (MRCI) and to examine the association between MRCI scores and subsequent acute visits.This cross-sectional study was conducted between April 1, 2019, and December 31, 2020, at a single-center, large, hospital-based, complex care clinic. Participants were children with SNI aged 1 to 18 years and 5 or more prescribed medications.Home medication regimen complexity was assessed using MRCI scores. The total MRCI score is composed of 3 subscores (dosage form, dose frequency, and specialized instructions).Patient-level counts of subscore characteristics and additional safety variables (total doses per day, high-alert medications, and potential drug-drug interactions) were analyzed by MRCI score groups (low, medium, and high score tertiles). Associations between MRCI score groups and acute visits were tested using Poisson regression, adjusted for age, complex chronic conditions, and recent health care use.Of 123 patients, 73 (59.3%) were male with a median (interquartile range [IQR]) age of 9 (5-13) years. The median (IQR) MRCI scores were 46 (35-61 [range, 8-139]) overall, 29 (24-35) for the low MRCI group, 46 (42-50) for the medium MRCI group, and 69 (61-78) for the high MRCI group. The median (IQR) counts for the subscores were 6 (4-7) dosage forms per patient, 7 (5-9) dose frequencies per patient, and 5 (4-8) instructions per patient, with counts increasing significantly across higher MRCI groups. Similar trends occurred for total daily doses (median [IQR], 31 [20-45] doses), high-alert medications (median [IQR], 3 [1-5] medications), and potential drug-drug interactions (median [IQR], 3 [0-6] interactions). Incidence rate ratios of 30-day acute visits were 1.26 times greater (95% CI, 0.57-2.78) in the medium MRCI group vs the low MRCI group and 2.42 times greater (95% CI, 1.10-5.35) in the high MRCI group vs the low MRCI group.Higher MRCI scores were associated with multiple dose frequencies, complicated by different dosage forms and instructions, and associated with subsequent acute visits. These findings suggest that clinical interventions to manage CMRs could target various aspects of these regimens, such as the simplification of dosing schedules.
Cryoballoon Ablation as Initial Treatment for Atrial Fibrillation
Authors: Jason G. Andrade, Oussama M. Wazni, Malte Kuniss, Nathaniel M. Hawkins, Marc W. Deyell, Gian-Battista Chierchia, Steven Nissen, Atul Verma, George A. Wells, Ricky D. Turgeon
Journal: Journal of the American College of Cardiology (2021)

Atrial fibrillation (AF), the most common sustained arrhythmia observed in clinical practice, is a chronic and progressive disorder characterized by exacerbations and remissions. Guidelines recommend antiarrhythmic drugs as the initial therapy for the maintenance of sinus rhythm; however, antiarrhythmic drugs have modest efficacy to maintain sinus rhythm and can be associated with significant adverse effects. An initial treatment strategy of cryoballoon catheter ablation in patients with treatment-naïve AF has been shown to significantly improve arrhythmia outcomes (freedom from any, or symptomatic atrial tachyarrhythmia), produce clinically meaningful improvements in patient-reported outcomes (symptoms and quality of life), and significantly reduce subsequent health care resource use (hospitalization), and it does not increase the risk of serious or any adverse events compared with initial antiarrhythmic drug therapy. These findings are relevant to inform patients, providers, and health care systems regarding the initial choice of rhythm-control therapy in patients with treatment-naïve AF.
Southeast Asia is an emerging hotspot for COVID-19
Authors: Thanat Chookajorn, Theerarat Kochakarn, Chaiwat Wilasang, Namfon Kotanan, Charin Modchang
Journal: Nature Medicine (2021)

Southeast Asia is an emerging hotspot for COVID-19To the Editor-The rise in COVID-19 cases in India has become an important lesson to the global community 1 .Because certain parts of the world have been left vulnerable to COVID-19, a humanitarian crisis at an unprecedented scale has emerged and spread to the rest of the world.The SARS-CoV-2 Delta variant (B.1.617.2) that evolved from the outbreak in India has set back the success of COVID-19 control measures in several developed countries 2 .Southeast Asia and its population of more than 655 million people could be the next hotspot due to geographical and socioeconomic factors, such as ongoing political unrest and the emergence of new variants.Southeast Asia is now being bombarded with three known variants of concern: B.1.1.7 (Alpha), B.1.351(Beta) and B.1.617.2 (Delta).The movement of workers between countries, often through illegal and unmonitored channels, in combination with a limited vaccine rollout, has put the whole region at risk from highly transmissible and immunoevasive variants.However, little information about this rising crisis is seen in the media or from the global medical community.In 2020, Southeast Asia was the role model in terms of COVID-19 control.The situation in mid-2021 has been transformed by the rise in case numbers.The average number of confirmed daily new cases in Southeast Asia has increased from more than 12,900 in March 2021 to 28,800 in June 2021, with a median time-varying reproduction number of 1.09, which indicates that the daily new cases are growing exponentially (Fig. 1a).The data are probably under-reported due to limited testing capacity.The degree of genetic variation in the available SARS-CoV-2 genomes in Thailand suggests that the virus has been propagating without detection for months 3 .From March 2021 to June 2021, the spread of the Alpha and Delta variants took over the region, which resulted in a collapse of the healthcare system.Starting in March 2021, the Alpha variant was circulating in Cambodia and Thailand (Fig. 1b).The public-health measures successfully implemented during the first wave in 2020 failed to control the new variant.
Examination of Dosing of Antipsychotic Drugs for Relapse Prevention in Patients With Stable Schizophrenia
Authors: Stefan Leucht, Sofia Bauer, Spyridon Siafis, Tasnim Hamza, Hui Wu, Johannes Schneider-Thoma, Georgia Salanti, John M. Davis
Journal: JAMA Psychiatry (2021)

The doses of antipsychotic drugs needed for relapse prevention in schizophrenia is a debated issue.
Randomized Clinical Trials in the Era of Precision Oncology—The Role of End Points, Industry Funding, and Medical Writing Integrity—Reply
Authors: Joseph C. Del Paggio, Elizabeth A. Eisenhauer, Christopher M. Booth
Journal: JAMA Oncology (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Association of Regional Wall Shear Stress and Progressive Ascending Aorta Dilation in Bicuspid Aortic Valve
Authors: Gilles Soulat, Michael B. Scott, Bradley D. Allen, Ryan Avery, Robert O. Bonow, S. Chris Malaisrie, Patrick McCarthy, Paul W.M. Fedak, Alex J. Barker, Michael Markl
Journal: JACC. Cardiovascular imaging (2021)
心臓発達におけるNKX2.5発現の持続のために必要とされる、Rae28(遺伝子における哺乳類のポリコームグループのメンバー)
Authors: Osugi T, Shirai M, Koga H, Nishiguchi S, Yamauchi-Takihara K, Takihara Y
Journal: Circulation (2000)
Estimating personal solar ultraviolet radiation exposure through time spent outdoors, ambient levels and modelling approaches*
Authors: L. Soueid, M. Triguero‐Mas, A. Dalmau, J. Barrera‐Gómez, L. Alonso, X. Basagaña, E. Thieden, H.C. Wulf, B. Diffey, A.R. Young, M. Nieuwenhuijsen, P. Dadvand
Journal: British Journal of Dermatology (2021)

Background Evidence on validation of surrogates applied to evaluate the personal exposure levels of solar ultraviolet radiation (UVR) in epidemiological studies is scarce. Objectives To determine and compare the validity of three approaches, including (i) ambient UVR levels, (ii) time spent outdoors and (iii) a modelling approach integrating the aforementioned parameters, to estimate personal UVR exposure over a period of 6 months among indoor and outdoor workers and in different seasons (summer/winter). Methods This validation study was part of the European Commission-funded ICEPURE project and was performed between July 2010 and January 2011 in a convenience sample of indoor and outdoor workers in Catalunya, Spain. We developed linear regression models to quantify the variation in the objectively measured personal UVR exposure that could be explained, separately, by the ambient UVR, time spent outdoors and modelled UVR levels. Results Our 39 participants – mostly male and with a median age of 35 years – presented a median daily objectively measured UVR of 0·37 standard erythemal doses. The UVR dose was statistically significantly higher in summer and for outdoor workers. The modelled personal UVR exposure and self-reported time spent outdoors could reasonably predict the variation in the objectively measured personal UVR levels (R2 range 0·75–0·79), whereas ambient UVR was a poor predictor (R2 = 0·21). No notable differences were found between seasons or occupation. Conclusions Time outdoors and our modelling approach were reliable predictors and of value to be applied in epidemiological studies of the health effects of current exposure to UVR.
A novel functional mast cell assay for the detection of allergies
Authors: Noemi Zbären, Daniel Brigger, Daniel Bachmann, Arthur Helbling, Lukas Jörg, Michael P. Horn, Johannes M. Schmid, Hans Jürgen Hoffmann, Jean-Pierre Kinet, Thomas Kaufmann, Alexander Eggel
Journal: Journal of Allergy and Clinical Immunology (2021)

Clinical management of allergic diseases has been hampered by the lack of safe and convenient tests to reliably identify culprit allergens and to closely follow changes in disease activity over time. Because allergy diagnosis is a complex and laborious multistep procedure, there is an urgent need for simpler but still functionally accurate ex vivo assays allowing objective diagnosis, substantiating treatment choices, and quantifying therapeutic responses.In this study, we sought to develop a novel functional cell-based assay that relies on passive sensitization of allergic effector cells with patient serum, circumventing current limitations in allergy diagnosis.We genetically engineered a conditional homeobox B8 (Hoxb8)-immortalized progenitor line from the bone marrow of mice that are transgenic for the human high-affinity IgE receptor (FcεRIα). These cells can be reproducibly differentiated into mature Hoxb8 mast cells within 5 days of culture in virtually unlimited numbers.We demonstrate that the established Hoxb8 mast cell assay can be used to accurately measure total IgE levels, identify culprit allergens, longitudinally monitor allergen-specific immunotherapy, and potentially determine the time point of tolerance induction upon allergen-specific immunotherapy in patients with allergy. To facilitate the analysis of large testing volumes, we demonstrate a proof-of-concept for a high-throughput screening application based on fluorescent cell barcoding using the engineered Hoxb8 mast cells.Our results indicate that this novel mast cell assay could represent a valuable tool to support clinicians in the identification of IgE-mediated allergies and in the quantification of treatment efficacy as well as duration of therapeutic response.
Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) enables accurate and user-friendly definitions of clinical remission and categories of disease activity
Authors: Diogo Jesus, Maddalena Larosa, Carla Henriques, Ana Matos, Margherita Zen, Paulo Tomé, Valter Alves, Nuno Costa, Véronique Le Guern, Luca Iaccarino, Nathalie Costedoat-Chalumeau, Andrea Doria, Luís Sousa Inês
Journal: Annals of the Rheumatic Diseases (2021)

Objectives There is an unmet need for accurate and user-friendly definitions of systemic lupus erythematosus (SLE) disease activity and remission. We aimed to derive and validate the SLE Disease Activity Score (SLE-DAS) definitions for disease activity categories and clinical remission state. Methods Derivation was conducted at Padova Lupus Clinic (Italy). Validation was prospectively performed at Cochin Lupus Clinic (France) and by post hoc analysis of BLISS-76 trial. At each clinic, an expert classified patients in three categories: remission, mild or moderate/severe activity. The SLE-DAS cut-offs were derived using the receiver operating characteristic curve analysis in Padova cohort; its performance was assessed against expert classification in Cochin cohort and British Isles Lupus Assessment Group (BILAG) index in BLISS-76. Gold standard for clinical remission state was the fulfilment of Definition Of Remission In SLE. A Boolean and an index-based definitions of remission were sustained by chi-square automatic interaction detection algorithm. An SLE-DAS online calculator was developed and tested. Results We included 1190 patients with SLE: 221 in the derivation cohort and 969 in the validation cohorts (150 from Cochin; 819 from BLISS-76). Derived cut-offs were: remission, SLE-DAS ≤2.08; mild activity, 2.08&lt;SLE-DAS≤7.64; moderate/severe activity, SLE-DAS &gt;7.64. Regarding validation in Cochin cohort, sensitivity and specificity are above 90%, 82% and 95% for remission, mild and moderate/severe activity, respectively. The SLE-DAS Boolean-based and index-based remission showed sensitivity of 100% and specificity above 97%. Conclusion The SLE-DAS is an accurate and easy-to-use tool for defining SLE clinical remission state and disease activity categories, validated against expert assessment and BILAG.
Болезни органов пищеварения — актуальная проблема клинической медицины
Authors: Yu.M. Stepanov, I.Yu. Skirda, O.P. Petishko
Journal: GASTROENTEROLOGY (2019)

Актуальность. Во всем мире ежегодно увеличивается количество людей, которые страдают заболеваниями желудочно-кишечного тракта и гепатобилиарной системы, а следовательно, нуждаются в специализированной гастроэнтерологической помощи. Цель: определение особенностей динамики и соотношения показателей распространенности и заболеваемости болезнями органов пищеварения (БОП) в Украине. Материалы и методы. В работе применялись структурно-логический анализ и клинико-статистический метод. Изучение показателей проводилось на основании анализа материалов официальной статистики Центра медицинской статистики МЗ Украины в течение 2014–2017 годов. Результаты. Доля БОП в общей структуре распространенности по классам болезней среди всего населения составляет 9,8 % и занимает 3 место (всего 43 нозологии), в структуре заболеваемости — 4,1 % и занимает 7 место. Индекс накопления болезней по классу БОТ среди взрослого населения Украины за 4 года вырос на 3,4 %. Гастроэнтерологическими заболеваниями болеют все возрастные группы населения: большинство пациентов находятся в работоспособной группе, вдвое меньше частота распространения БОП среди детей, распространенность среди городского населения в 2 раза выше, чем среди сельского. Наибольший показатель заболеваемости в 2017 г. (более 4 тыс. на 100 тыс. населения) отмечен в Закарпатской, Ивано-Франковской и Ровенской областях; наименьший (ниже 2 тыс. на 100 тыс. населения) наблюдается в Луганской, Запорожской и Херсонской областях. Самая высокая распространенность (более 22 тыс. на 100 тыс. населения) зарегистрирована в Днепропетровской, Киевской и Черниговской областях; самая низкая (менее 12 тыс. на 100 тыс. населения) — в Запорожской, Львовской и Волынской областях. Выводы. Представленные результаты подчеркивают медико-социальную актуальность болезней органов пищеварения, что обусловливает необходимость разработки и внедрения в практическое здравоохранение новых методов диагностики и лечения, а также проведения комплексной организационной стратегии здравоохранения в разделе гастроэнтерологии как на государственном, так и региональном уровнях.
Bleeding Avoidance Strategies and Percutaneous Coronary Intervention—Reply
Authors: Steven P. Marso
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Patch grafting, strategies for transplantation of organoids into solid organs such as liver
Authors: Wencheng Zhang, Giacomo Lanzoni, Homayoun Hani, Diletta Overi, Vincenzo Cardinale, Sean Simpson, Wendy Pitman, Amanda Allen, Xianwen Yi, Xicheng Wang, David Gerber, Glenn Prestwich, Oswaldo Lozoya, Eugenio Gaudio, Domenico Alvaro, Debra Tokaz, Juan Dominguez-Bendala, Christopher Adin, Jorge Piedrahita, Kyle Mathews, Praveen Sethupathy, Guido Carpino, Zhiying He, Eliane Wauthier, Lola M. Reid
Journal: Biomaterials (2021)
Automated Noncontrast Myocardial Tissue Characterization for Hypertrophic Cardiomyopathy: Holy Grail or False Prophet?
Authors: Charlotte H Manisty, Jennifer H. Jordan, W. Gregory Hundley
Journal: Circulation (2021)

oninvasive cardiovascular imaging is fundamental to diagnosis, surveillance, risk stratification, and management of patients with hypertrophic cardiomyopathy (HCM).Although transthoracic echocardiography more frequently identifies or confirms the presence of HCM, cardiovascular magnetic resonance (CMR) is increasingly recommended to exclude phenocopies, screen family members, and make decisions about implantable cardiac defibrillator implantation to prevent sudden cardiac death.
26353 Comparative effectiveness of acne scar treatments: A systematic review and network meta-analysis
Authors: Sarah A. Ibrahim, Melanie A. Clark, Kelly A. Reynolds, Sanjana Iyengar, Vishnu B. Harikumar, Bianca Y. Kang, Emily Poon, Jonathan I. Silverberg, Murad Alam
Journal: Journal of the American Academy of Dermatology (2021)
VariantStore: an index for large-scale genomic variant search
Authors: Prashant Pandey, Yinjie Gao, Carl Kingsford
Journal: Genome biology (2021)

Efficiently scaling genomic variant search indexes to thousands of samples is computationally challenging due to the presence of multiple coordinate systems to avoid reference biases. We present VariantStore, a system that indexes genomic variants from multiple samples using a variation graph and enables variant queries across any sample-specific coordinate system. We show the scalability of VariantStore by indexing genomic variants from the TCGA project in 4 h and the 1000 Genomes project in 3 h. Querying for variants in a gene takes between 0.002 and 3 seconds using memory only 10% of the size of the full representation.