tbuckley/cabot-search huggingface dataset:
Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections
Authors: Hani Harb, Mehdi Benamar, Peggy S. Lai, Paola Contini, Jason W. Griffith, Elena Crestani, Klaus Schmitz-Abe, Qian Chen, Jason Fong, Luca Marri, Gilberto Filaci, Genny Del Zotto, Novalia Pishesha, Stephen Kolifrath, Achille Broggi, Sreya Ghosh, Metin Yusuf Gelmez, Fatma Betul Oktelik, Esin Aktas Cetin, Ayca Kiykim, Murat Kose, Ziwei Wang, Ye Cui, Xu G. Yu, Jonathan Z. Li, Lorenzo Berra, Emmanuel Stephen-Victor, Louis-Marie Charbonnier, Ivan Zanoni, Hidde Ploegh, Gunnur Deniz, Raffaele De Palma, Talal A. Chatila
Journal: Immunity (2021)
DETERMINING THE MECHANISM OF MYOCARDIAL INJURY AND ROLE OF CORONARY ARTERY DISEASE IN TYPE 2 MYOCARDIAL INFARCTION (DEMAND-MI)
Authors: Andrew R. Chapman, Anda Bularga, John Hung, Marwa Daghem, Caelan Taggart, Stacey Stewart, Takeshi Fujisawa, Justin Wei Chiong, Fiona Strachan, Scott Semple, Edwin Van Beek, Michelle Williams, William Jenkins, Marc Dweck, David Newby, Nicholas Mills
Journal: Journal of the American College of Cardiology (2021)
TRANSBRACHIAL INTRA-AORTIC BALLOON PUMP PLACEMENT IN CARDIOGENIC SHOCK: AN OLD ROUTE TO EMERGENTLY DEAL WITH A GROWING PROBLEM
Authors: Kunal Kapoor, April Shewmake, Owais Idris, Justin Heizer, Deepak Thomas, Richard Cooke, Zachary Gertz, Barbara Lawson, Lorenzo Azzalini
Journal: Journal of the American College of Cardiology (2021)
Emergence of additional drug resistance during treatment of multidrug-resistant tuberculosis in China: a prospective cohort study
Authors: Yi Hu, Xubin Zheng, Lina Davies Forsman, Zhu Ning, Cheng Chen, Yazhou Gao, Zhengdong Zhang, Wei Lu, Jim Werngren, Judith Bruchfeld, Sven Hoffner, Biao Xu
Journal: Clinical Microbiology and Infection (2021)
HIGH-SENSITIVITY CARDIAC TROPONIN T FOR THE DETECTION OF MYOCARDIAL INJURY AND RISK STRATIFICATION IN COVID-19
Authors: Laura De Michieli, Olatunde Ola, Jonathan Knott, Ashok Akula, Ramila Mehta, David Hodge, Marshall Dworak, Eric Yang, S. Gharacholou, Gurpreet Singh, Ripudamanjit Singh, Rajiv Gulati, Allan Jaffe, Yader Sandoval
Journal: Journal of the American College of Cardiology (2021)
Targeting hyperactive TGFBR2 for treating MYOCD deficient lung cancer
Authors: Qian Zhou, Wensheng Chen, Zhenzhen Fan, Zhipeng Chen, Jinxia Liang, Guandi Zeng, Lu Liu, Wanting Liu, Tong Yang, Xin Cao, Biao Yu, Meng Xu, Ye-Guang Chen, Liang Chen
Journal: Theranostics (2021)

Purpose: Clinical success of cancer therapy is severely limited by drug resistance, attributed in large part to the loss of function of tumor suppressor genes (TSGs). Developing effective strategies to treat those tumors is challenging, but urgently needed in clinic. Experimental Design: MYOCD is a clinically relevant TSG in lung cancer patients. Our in vitro and in vivo data confirm its tumor suppressive function. Further analysis reveals that MYOCD potently inhibits stemness of lung cancer stem cells. Mechanistically, MYOCD localizes to TGFBR2 promoter region and thereby recruits PRMT5/MEP50 complex to epigenetically silence its transcription. Conclusions: NSCLC cells deficient of MYOCD are particularly sensitive to TGFBR kinase inhibitor (TGFBRi). TGFBRi and stemness inhibitor synergize with existing drugs to treat MYOCD deficient lung cancers. Our current work shows that loss of function of MYOCD creates Achilles' heels in lung cancer cells, which might be exploited in clinic.
The Impact of Intensifying Prostate Cancer Screening in Black Men: A Model-Based Analysis
Authors: Yaw A Nyame, Roman Gulati, Eveline A M Heijnsdijk, Alex Tsodikov, Angela B Mariotto, John L Gore, Ruth Etzioni
Journal: JNCI Journal of the National Cancer Institute (2021)

Abstract Background Black men in the United States have markedly higher rates of prostate cancer than the general population. National guidelines for prostate-specific antigen (PSA) screening do not provide clear guidance for this high-risk population. The purpose of this study is to estimate the benefit and harm of intensified PSA screening in Black men. Methods Two microsimulation models of prostate cancer calibrated to incidence from the Surveillance, Epidemiology, and End Results program among Black men project the impact of different screening strategies (varying screening intervals, starting and stopping ages, and biopsy utilization following an abnormal PSA) on disease-specific mortality and overdiagnosis. Each strategy induces a mean lead time (MLT) for detected cases. A longer MLT reduces mortality according to estimates combining the US and European prostate cancer screening trials but increases overdiagnosis. Results Under historical population screening, Black men had similar MLT to men of all races and similar mortality reduction (range between models = 21%-24% vs 20%-24%) but a higher frequency of overdiagnosis (75-86 vs 58-60 per 1000 men). Screening Black men aged 40-84 years annually would increase both mortality reduction (29%-31%) and overdiagnosis (112-129 per 1000). Restricting screening to ages 45-69 years would still achieve substantial mortality reduction (26%-29%) with lower overdiagnosis (51-61 per 1000). Increasing biopsy utilization to 100% of abnormal tests would further reduce mortality but substantially increase overdiagnosis. Conclusions Annual screening in Black men is expected to reduce mortality more than that estimated under historical screening. Limiting screening to men younger than 70 years is expected to help reduce overdiagnosis.
A NOVEL 2D ECHOCARDIOGRAPHY METHOD TO OBJECTIVELY QUANTIFY AORTIC VALVE CALCIUM AND PREDICT AORTIC STENOSIS SEVERITY
Authors: Brody Slostad, Aamir Twing, Kevin Lee, Colin Hubbard, Elliott Groves, Leon Frazin, Mayank Kansal
Journal: Journal of the American College of Cardiology (2021)
Abstract 13905: Machine Learning to Guide Dose Decisions for Dofetilide
Authors: Andrew E Levy, Minakshi Biswas, Rachel Weber, Khaldoun Tarakji, Mina K Chung, Peter A Noseworthy, Christopher Newton-Cheh, Michael A Rosenberg
Journal: Circulation (2019)

Introduction: Although a recommended algorithm exists for dose adjustments of dofetilide during the FDA-mandated 3-day loading period, real-world experience suggests that providers frequently devia...
EFFICACY OF NEWER ACCELERATED THROMBOLYTIC REGIMEN USING TENECTEPLASE [ACCELERATED MMC REGIMEN] FOR PROSTHETIC VALVE THROMBOSIS
Authors: Justin Paul Gnanaraj, G. Jegan, Midhun Kumar, Swaminathan Nagarajan, Elangovan Chandrasekaran, Srinivasan Kumaran, Elavarasi Manimegalai
Journal: Journal of the American College of Cardiology (2021)
ASSOCIATIONS AND OUTCOMES OF CONGENITAL HEART BLOCK IN THE NEONATAL PERIOD: A NATIONWIDE DATA ANALYSIS
Authors: Anas Abdul Kayoum, Jun Sasaki, Prithvi Sendi, Balagangadhar Totapally, Estefania Rivera Flores, Saleem Almasarweh, Ronald Kanter
Journal: Journal of the American College of Cardiology (2021)
Erratum. Relations Between Subclinical Disease Markers and Type 2 Diabetes, Metabolic Syndrome, and Incident Cardiovascular Disease: The Jackson Heart Study. Diabetes Care 2015;38:1082–1088
Authors: Vanessa Xanthakis, Jung Hye Sung, Tandaw E. Samdarshi, Alethea N. Hill, Solomon K. Musani, Mario Sims, Kamel A. Gharaibeh, Philip R. Liebson, Herman A. Taylor, Ramachandran S. Vasan, Ervin R. Fox
Journal: Diabetes Care (2021)
BICUSPID AORTIC VALVE MORPHOLOGY IS HETEROGENOUS AMONG FIRST-DEGREE RELATIVES - A FAMILY-BASED STUDY
Authors: Idit Tessler, Guillaume Goudot, Juliette Albuisson, Shoshana Shpitzen, Donna Zwas, Emmanuel Messas, Dan Gilon, Ronen Durst
Journal: Journal of the American College of Cardiology (2021)
Acute Lymphoblastic Leukemia/Lymphoma in the Elderly: The Mayo Clinic Experience
Authors: Kevin C. Miller, Aref Al-Kali, William J. Hogan, Michelle A. Elliott, Kebede H. Begna, Naseema Gangat, Mrinal M. Patnaik, Lisa Sproat, James M. Foran, Mark R. Litzow, Hassan B. Alkhateeb
Journal: Blood (2017)
THE ROLE OF SMOKING ON CRYOBALLOON ABLATION OUTCOMES FOR PAROXYSMAL ATRIAL FIBRILLATION
Authors: Abhishek Bose, Parag Anilkumar Chevli, Zeba Hashmath, Ajay K. Mishra, Gregory Berberian, Jerzy Januszkiewicz, Ghasan Ahmad
Journal: Journal of the American College of Cardiology (2021)
Association between Der p 23 and asthma in children sensitized to house dust mite
Authors: Yuya Tanaka, Saori Omae, Ikuo Okafuji, Taro Ueda, Tamaki Ito, Yuko Mitobe, Katsuyo Ohashi-Doi, Satoru Tsuruta
Journal: Journal of Allergy and Clinical Immunology (2020)
PHARMACODYNAMIC EFFECTS OF ADJUNCTIVE CLOPIDOGREL THERAPY IN PATIENTS WITH ATHEROSCLEROTIC DISEASE ON DUAL PATHWAY INHIBITION WITH ASPIRIN AND LOW-DOSE RIVAROXABAN
Authors: Francesco Franchi, Fabiana Rollini, Latonya Been, Patrick Abou Jaoude, Andrea Rivas, Xuan Zhou, Sida Jia, Naji Maaliki, Chang Hoon Lee, Andres Pineda Maldonado, Siva Suryadevara, Daniel Soffer, Martin Zenni, Lisa Jennings, Theodore Bass, Dominick Angiolillo
Journal: Journal of the American College of Cardiology (2021)
Covid-19: One dose of vaccine cuts risk of passing on infection by as much as 50%, research shows
Authors: Elisabeth Mahase
Journal: BMJ (2021)

One dose of vaccine cuts risk of passing on infection by as much as 50%, research shows Elisabeth MahaseAdults infected with covid-19 three weeks after receiving one dose of the Pfizer-BioNTech or Oxford-AstraZeneca vaccine were 38-49% less likely to pass the virus on to their household contacts than people who were unvaccinated, a preprint released by Public Health England has shown. 1
Four distinct trajectories of tau deposition identified in Alzheimer’s disease
Authors: Jacob W. Vogel, Alexandra L. Young, Neil P. Oxtoby, Ruben Smith, Rik Ossenkoppele, Olof T. Strandberg, Renaud La Joie, Leon M. Aksman, Michel J. Grothe, Yasser Iturria-Medina, Michael J. Pontecorvo, Michael D. Devous, Gil D. Rabinovici, Daniel C. Alexander, Chul Hyoung Lyoo, Alan C. Evans, Oskar Hansson
Journal: Nature Medicine (2021)
A soft and transparent contact lens for the wireless quantitative monitoring of intraocular pressure
Authors: Joohee Kim, Jihun Park, Young-Geun Park, Eunkyung Cha, Minjae Ku, Hyeon Seok An, Kyoung-Pil Lee, Man-Il Huh, Junmo Kim, Taek-Soo Kim, Dai Woo Kim, Hong Kyun Kim, Jang-Ung Park
Journal: Nature Biomedical Engineering (2021)
Detection of Molecular Signatures of Homologous Recombination Deficiency in Bladder Cancer
Authors: Judit Börcsök, Miklos Diossy, Zsofia Sztupinszki, Aurel Prosz, Viktoria Tisza, Sandor Spisak, Orsolya Rusz, Dag R. Stormoen, Helle Pappot, Istvan Csabai, Søren Brunak, Kent W. Mouw, Zoltan Szallasi
Journal: Clinical Cancer Research (2021)

Abstract Purpose: Poly (ADP ribose)-polymerase (PARP) inhibitors are approved for use in breast, ovarian, prostate, and pancreatic cancers, which are the solid tumor types that most frequently have alterations in key homologous recombination (HR) genes, such as BRCA1/2. However, the frequency of HR deficiency (HRD) in other solid tumor types, including bladder cancer, is less well characterized. Experimental Design: Specific DNA aberration profiles (mutational signatures) are induced by HRD, and the presence of these “genomic scars” can be used to assess the presence or absence of HRD in a given tumor biopsy even in the absence of an observed alteration of an HR gene. Using whole-exome and whole-genome data, we measured various HRD-associated mutational signatures in bladder cancer. Results: We found that a subset of bladder tumors have evidence of HRD. In addition to a small number of tumors with biallelic BRCA1/2 events, approximately 10% of bladder tumors had significant evidence of HRD-associated mutational signatures. Increased levels of HRD signatures were associated with promoter methylation of RBBP8, which encodes CtIP, a key protein involved in HR. Conclusions: A subset of bladder tumors have genomic features suggestive of HRD and therefore may be more likely to benefit from therapies such as platinum agents and PARP inhibitors that target tumor HRD.
PLASMA BIOMARKERS FOR RISK STRATIFICATION OF OUTCOMES IN PATIENTS WITH AORTIC STENOSIS
Authors: Mahesh Vidula, Alena Orlenko, Lei Zhao, Lisa Salvador, Aeron Smalll, Edward Horton, Jordana Cohen, Caroline Margo, Bibi Singh, Bianca Pourmussa, Candy Greczylo, Melissa Yarde, Zhuyin Li, Mary Ellen Cvijic, Zhaoqing Wang, Peter Schafer, Francisco Ramirez-Valle, Dietmar Seiffert, David Gordon, Daniel Rader, Julio Chirinos
Journal: Journal of the American College of Cardiology (2021)
OUTCOMES OF PATIENTS WITH CARDIAC AMYLOIDOSIS UNDERGOING ANESTHESIA
Authors: Karl Shaver, Michelle Humeidan, Cyril Ayuk, Mbeng Baiyee, Brandon Rogers, Samir Parikh, Salem Almaani, Jordan Bittengle, Katherine Pfund, Samantha LoRusso, Miriam Freimer, Elyse Redder, Naresh Bumma, Ajay Vallakati, Yvonne Efebera, Rami Kahwash
Journal: Journal of the American College of Cardiology (2021)
Clinical Impact of High-Sensitivity Cardiac Troponin T Implementation in the Community
Authors: Olatunde Ola, Ashok Akula, Laura De Michieli, Marshall Dworak, Erika Crockford, Ronstan Lobo, Nicholas Rastas, Jonathan D. Knott, Ramila A. Mehta, David O. Hodge, Eric Grube, Swetha Karturi, Scott Wohlrab, Tahir Tak, Charles Cagin, Rajiv Gulati, Allan S. Jaffe, Yader Sandoval
Journal: Journal of the American College of Cardiology (2021)
CHRONIC TOTAL OCCLUSION PERCUTANEOUS CORONARY INTERVENTION DURING COVID-19 PANDEMIC, INSIGHTS FROM THE PROGRESS-CTO REGISTRY
Authors: Evangelia Vemmou, Khaldoon Alaswad, Jaikirshan Khatri, Jason Wollmuth, Oleg Krestianinov, Dmitrii Khelimskii, James Choi, Farouc Jaffer, Ahmed ElGuindy, Nidal Abi Rafeh, Robert Riley, Niranjan Reddy, Omer Goktekin, James Flaherty, Keith Benzuly, Daniel Schimmel, Raj Chandwaney, Ioannis Tsiafoutis, Michael Koutouzis, Ilias Nikolakopoulos, Judit Karacsonyi, Bavana Rangan, Santiago Garcia, M. Nicholas Burke, Emmanouil Brilakis
Journal: Journal of the American College of Cardiology (2021)
Incorrect Variable Description
Authors: Anjali Jain, Jaclyn Marshall, Ami Buikema, Tim Bancroft, Jonathan Kelly, Craig Newschaffer, Marshall Jain
Journal: JAMA (2016)

Anjali Jain, MD; Jaclyn Marshall, MS; Ami Buikema, MPH; Tim Bancroft, PhD; Jonathan P. Kelly, MPP; Craig J. Newschaffer, PhD
MODERATE/SEVERE MITRAL REGURGITATION AND TRICUSPID REGURGITATION ASSOCIATED WITH INCREASED MORTALITY IN HOSPITALIZED PATIENTS WITH COVID-19
Authors: Usman Hasnie, Ammar Hasnie, Anna Gann, Marquis Griffin, Olivia Hudson, Karan Sarode, Bo Wang, Miguel Sotelo, Loren Wagner, Chris Rodgers, Logan Brigman, Daniel O’Hair, Navjot Kohli, Efstathia Andrikopoulou
Journal: Journal of the American College of Cardiology (2021)
Abstract 11058: Relative Contribution of Modifiable Risk Factors for Atrial Fibrillation in Hispanics, African Americans and Non-Hispanic Whites
Authors: Eric H Shulman, Jay Chudow, Utibe R Essien, Anusha Shanbhag, Faraj Kargoli, Jorge Romero, Luigi DiBiase, John Fisher, Ileana Pina, Andrew Krumerman, Kevin J Ferrick
Journal: Circulation (2018)

Introduction: Contribution of modifiable risk factors for the development of atrial fibrillation (AF) in minority populations is poorly understood. Hypothesis: There exists a difference in the popu...
Abstract 18885: High Sensitivity Cardiac Troponin-T and Subsequent Risk of Hospitalization With Bleeding: The Atherosclerosis in Communities (ARIC) Study
Authors: Lena Mathews, Junichi Ishigami, Ron C Hoogeveen, Anna Kucharska-Newton, Christie M Ballantyne, Rebecca F Gottesman, Elizabeth Selvin, Kunihiro Matsushita
Journal: Circulation (2017)

Introduction: Elevated high sensitivity cardiac troponin (hs-cTnT), a marker of myocardial damage, has been shown to predict bleeding events in some clinical populations such as patients with upper...
ANATOMICAL PREDICTORS AND CLINICAL IMPLICATIONS OF MILD OR LESS (0/1+) MR AFTER TMVR: RESULTS FROM THE GLOBAL EXPAND STUDY
Authors: Philipp Lurz, Rodrigo Estevez-Loureiro, Ralph Stephan Von Bardeleben, Pooja Singhal, Lixian Sun, Jose Zamorano, Federico Asch, Francesco Maisano, Saibal Kar
Journal: Journal of the American College of Cardiology (2021)
IL-1R1–dependent signaling coordinates epithelial regeneration in response to intestinal damage
Authors: Christian B. Cox, Elaine E. Storm, Varun N. Kapoor, Joseph Chavarria-Smith, David L. Lin, Lifen Wang, Yun Li, Noelyn Kljavin, Naruhisa Ota, Travis W. Bainbridge, Keith Anderson, Merone Roose-Girma, Søren Warming, Joseph R. Arron, Shannon J. Turley, Frederic J. de Sauvage, Menno van Lookeren Campagne
Journal: Science Immunology (2021)

Repair of the intestinal epithelium is tightly regulated to maintain homeostasis. The response after epithelial damage needs to be local and proportional to the insult. How different types of damage are coupled to repair remains incompletely understood. We report that after distinct types of intestinal epithelial damage, IL-1R1 signaling in GREM1+ mesenchymal cells increases production of R-spondin 3 (RSPO3), a Wnt agonist required for intestinal stem cell self-renewal. In parallel, IL-1R1 signaling regulates IL-22 production by innate lymphoid cells and promotes epithelial hyperplasia and regeneration. Although the regulation of both RSPO3 and IL-22 is critical for epithelial recovery from Citrobacter rodentium infection, IL-1R1-dependent RSPO3 production by GREM1+ mesenchymal cells alone is sufficient and required for recovery after dextran sulfate sodium-induced colitis. These data demonstrate how IL-1R1-dependent signaling orchestrates distinct repair programs tailored to the type of injury sustained that are required to restore intestinal epithelial barrier function.
LEIOMYOMA-GOSH IT’S A TUMOR: A CASE OF A MASSIVE METASTATIC LEIOMYOMA WITH METASTATIC SPREAD TO THE RIGHT HEART CAUSING PULMONARY EMBOLIZATION
Authors: Eric Torkildsen, Mario Caruso, Jeffrey Wright, Zeel Patel, Ellina Feiner, Timothy Misselbeck
Journal: Journal of the American College of Cardiology (2021)
ECHOCARDIOGRAPHIC FEATURES OF IMMUNE CHECKPOINT INHIBITOR ASSOCIATED MYOCARDITIS AND THEIR ASSOCIATION WITH ADVERSE OUTCOMES
Authors: Olusola Orimoloye, John R. Power, Joseph Nowatzke, Andrew M. Hughes, Lorenz Lehmann, Jennifer Cautela, Mandar Aras, Alison Weppler, Anna Narezkina, Giovanni Peretto, Michal Pela, Shanthini M. Crusz, Aarti Asnani, Joe-Elie Salem, Anita Deswal, Nicolas Palaskas, Javid Moslehi
Journal: Journal of the American College of Cardiology (2021)
Supramolecular co-assembly of self-adjuvanting nanofibrious peptide hydrogel enhances cancer vaccination by activating MyD88-dependent NF-κB signaling pathway without inflammation
Authors: Qi Su, Huijuan Song, Pingsheng Huang, Chuangnian Zhang, Jing Yang, Deling Kong, Weiwei Wang
Journal: Bioactive Materials (2021)

Peptide vaccine targeting tumor-specific antigens is a promising cancer treatment regimen. However, peptide vaccines are commonly low-immunogenic, leading to suboptimal antitumor T-cell responses. Current peptide vaccination approaches are challenged by the variability of peptide physicochemical characters and vaccine formulations, flexibility, and the broad feasibility. Here, the supramolecular co-assembly of antigen epitope-conjugated peptides (ECPs) targeting CD8 or CD4 T-cell receptors was used to engineer a nanofibrious hydrogel vaccine platform. This approach provided precise and tunable loading of peptide antigens in nanofibers, which notably increased the antigen uptake, cross-presentation, and activation of dendritic cells (DCs). Immunization in mice indicated that the co-assembled peptide hydrogel did not induce local inflammation responses and elicited significantly promoted T-cell immunity by activating the MyD88-dependent NF-κB signaling pathway in DCs. Vaccination of mice using co-assembled peptide vaccine stimulated both enhanced CD8 and CD4 T cells against EG.7-OVA tumors without additional immunoadjuvants or delivery systems, and resulted in a more remarkable cancer immunotherapy efficacy, compared with free peptide vaccine or aluminum-adjuvanted peptide formulation. Altogether, peptide co-assembly demonstrated by three independent pairs of ECPs is a facile, customizable, and chemically defined approach for co-delivering peptide antigens in self-adjuvanting hydrogel vaccines that could induce stronger anticancer T-cell responses.
Switching to or Add-on Peginterferon in Patients on Nucleos(t)ide Analogues for Chronic Hepatitis B: The SWAP RCT
Authors: Seng Gee Lim, Wei Lyn Yang, Jing Hieng Ngu, Jason Chang, Jessica Tan, Taufique Ahmed, Yock Young Dan, Kieron Lim, Yin Mei Lee, Guan Huei Lee, Poh Seng Tan, Khin Lay Wai, Wah Wah Phyo, Htet Htet Toe Wai Khine, Chris Lee, Amy Tay, Edwin Chan
Journal: Clinical Gastroenterology and Hepatology (2021)
Control of Immunity by the Microbiota
Authors: Eduard Ansaldo, Taylor K. Farley, Yasmine Belkaid
Journal: Annual Review of Immunology (2021)

The immune system has coevolved with extensive microbial communities living on barrier sites that are collectively known as the microbiota. It is increasingly clear that microbial antigens and metabolites engage in a constant dialogue with the immune system, leading to microbiota-specific immune responses that occur in the absence of inflammation. This form of homeostatic immunity encompasses many arms of immunity, including B cell responses, innate-like T cells, and conventional T helper and T regulatory responses. In this review we summarize known examples of innate-like T cell and adaptive immunity to the microbiota, focusing on fundamental aspects of commensal immune recognition across different barrier sites. Furthermore, we explore how this cross talk is established during development, emphasizing critical temporal windows that establish long-term immune function. Finally, we highlight how dysregulation of immunity to the microbiota can lead to inflammation and disease, and we pinpoint outstanding questions and controversies regarding immune system–microbiota interactions.
SARS-COV-2 AND STROKE IN A LARGE HEALTHCARE SYSTEM
Authors: Aashish Katapadi, Viviana Zlochiver, Ana Cristina Perez Moreno, Ilana Ruff, Michael Peterson, Suhail Allaqaband, A. Jamil Tajik, Bijoy Khandheria, Tanvir Bajwa, M. Fuad Jan
Journal: Journal of the American College of Cardiology (2021)