tbuckley/cabot-search huggingface dataset:
Evidence for a role of iron-catalyzed oxidants in functional and metabolic stunning in the canine heart.
Authors: N EFarber, G MVercellotti, H SJacob, G MPieper, G JGross
Journal: Circulation Research (1988)

Brief (15-minute) coronary occlusion and subsequent reperfusion lead to prolonged functional and metabolic abnormalities (stunned myocardium). Previous work suggests that one factor responsible for this phenomenon is oxygen-derived free radicals. The formation of the highly reactive hydroxyl radical requires the presence of metal ions, most importantly iron. In the present study, the effect of the iron-chelator deferoxamine on the recovery of segment shortening (%SS) in the stunned myocardium was compared with a control group in barbital anesthetized dogs. Deferoxamine (500 mg intra-atrially) was administered 15 minutes prior to and throughout 15 minutes of coronary occlusion. %SS, regional myocardial blood flow, hemodynamics, and myocardial high-energy phosphates were measured. Areas at risk, collateral blood flow, and all hemodynamic parameters were similar between control and deferoxamine-treated animals. While deferoxamine did not prevent the loss of systolic wall function that occurred during ischemi...
Squamous cell carcinoma subverts adjacent histologically normal epithelium to promote lateral invasion
Authors: Priyanka Singh, Rajat Banerjee, Songlin Piao, Marcell Costa de Medeiros, Emily Bellile, Min Liu, Dilna Damodaran Puthiya Veettil, Ligia B. Schmitd, Nickole Russo, Erika Danella, Ronald C. Inglehart, Kyriel M. Pineault, Deneen M. Wellik, Greg Wolf, Nisha J. D’Silva
Journal: The Journal of Experimental Medicine (2021)

Recurrent and new tumors, attributed in part to lateral invasion, are frequent in squamous cell carcinomas and lead to poor survival. We identified a mechanism by which cancer subverts adjacent histologically normal epithelium to enable small clusters of cancer cells to burrow undetected under adjacent histologically normal epithelium. We show that suppression of DMBT1 within cancer promotes aggressive invasion and metastasis in vivo and is associated with metastasis in patients. Cancer cells via TGFβ1 and TNFα also suppress DMBT1 in adjacent histologically normal epithelium, thereby subverting it to promote invasion of a small population of tumor cells. The sufficiency of DMBT1 in this process is demonstrated by significantly higher satellite tumor nests in Dmbt1-/- compared with wild-type mice. Moreover, in patients, invasion of small tumor nests under adjacent histologically normal epithelium is associated with increased risk for recurrence and shorter disease-free survival. This study demonstrates a crucial role of adjacent histologically normal epithelium in invasion and its important role in the tumor microenvironment and opens new possibilities for therapeutic strategies that reduce tumor recurrence.
Effects of brief repetitive ischemia on contractility, relaxation, and coronary flow. Exaggerated postischemic diastolic dysfunction in pressure-overload hypertrophy.
Authors: TMochizuki, F REberli, SNgoy, C SApstein, B HLorell
Journal: Circulation Research (1993)

The recovery of systolic and diastolic function during unstable angina may be modified by the repetition of brief episodes of ischemia and by the presence of left ventricular hypertrophy (LVH). We studied the effects of six consecutive 5-minute cycles of no-flow ischemia and reperfusion followed by 25 minutes of recovery in isovolumic red blood cell-perfused hearts from aortic-banded rats with chronic LVH (n = 8) and sham-operated control rats (n = 8). At baseline (left ventricular end-diastolic pressure [LVEDP], 10 mm Hg), left ventricular developed pressure (123 +/- 5 versus 114 +/- 5 mm Hg/g) and coronary flow [2.5 +/- 0.3 versus 2.2 +/- 0.2 (mL/min)/g] were similar in LVH versus control rats. Repetitive ischemia was associated with progressive depression of postischemic recovery of left ventricular systolic function, and the recovery of left ventricular developed pressure after the final 25-minute reperfusion period was similar in LVH versus control rats (61 +/- 6% versus 72 +/- 4% of baseline, P = NS...
Response to: ‘The autoantibody repertoire in periodontitis: a role in the induction of autoimmunity to citrullinated proteins in rheumatoid arthritis? Antibodies against uncitrullinated peptides seem to occur prior to the antibodies to the corresponding citrullinated peptides’ by Brink<i>et al</i>
Authors: Paola de Pablo, Thomas Dietrich, Iain L C Chapple, Michael Milward, Christopher D Buckley, Patrick J Venables
Journal: Annals of the Rheumatic Diseases (2014)

We would like to thank Brink et al 1 for their interest in our paper. The authors reported that antibodies against arginine-containing peptides from rheumatoid arthritis (RA) autoantigens were present in a population-based sample of 386 individuals with pre-RA. These pre-dated the corresponding antibodies against citrullinated peptides which appeared closer to onset of symptoms.

These results are in line with our results, …
Effects of reperfusion on ischemic right ventricular dysfunction. Disparate mechanisms of benefit related to duration of ischemia.
Authors: S BLaster, YOhnishi, J ESaffitz, J AGoldstein
Journal: Circulation (1994)

BACKGROUNDRight ventricular free wall (RVFW) ischemia impairs global RV performance and may result in acute hemodynamic compromise. However, RV function and hemodynamic performance typically improve spontaneously over time. This study was designed to determine whether reperfusion facilitates recovery of function in the ischemic right ventricle.METHODS AND RESULTSClosed chest dogs underwent right coronary balloon occlusion for 1 hour (n = 9), 4 hours (n = 6), or 8 hours (n = 7). In all animals, occlusion depressed RVFW function and global RV performance. After 1 hour of ischemia, reperfusion led to immediate improvement in RVFW function and consequently global RV performance, with complete recovery over 4 weeks and scar in < 1% of total RVFW area. Reperfusion after 4- and 8-hour occlusions resulted in acute improvement in global RV performance but to a lesser extent and by different mechanisms, since RVFW contraction remained severely impaired. This disproportionate recovery of global RV function was attri...
Diagnoctic Yield of Colonoscopy in Chronic Constipation: Comparative Study According to the Age
Authors: S Bradai, A Khsiba, M Medhioub, M Mahmoudi, A Ben mohamed, L Hamzaoui, MM Azzouz
Journal: Endoscopy (2021)

Aims Constipation can be the expression of an organic or functional disease. A colonoscopy is required for patients with chronic constipation resistant to symptomatic treatments or with alarm symptoms.The aim of this work was to assess the value of colonoscopy in the exploration of chronic constipation according to the patient’s age.
Disappearance of bradykinin in the renal circulation of dogs. Effects of kininase inhibition.
Authors: ANasjletti, JColina-Chourio, J CMcGiff
Journal: Circulation Research (1975)

In chloralose-anesthetized dogs, we investigated the disappearance of bradykinin on passage across the renal circulation. The peptide was infused into a renal artery at various doses (5-200 ng/kg min-1); renal blood flow and the concentration of kinins in renal venous blood were then determined and the percent survival of bradykinin on passage through the kidney calculated. Bradykinin caused a dose-related increase in renal blood flow, urine flow, sodium excretion, and kinin content of renal venous blood. Intravenous administration of BPP9alpha (300 mug/kg), a peptide kininase II inhibitor, potentiated the renal vasodilator, diuretic, and natriuretic actions of bradykinin and augmented the survival of the kinin on passage through the kidney from 12.72 +/- 1.64% in control dogs to 53.92 +/- 7.48% (P less than 0.001). Furthermore, the values of peptide survival were positively correlated with the increases in renal blood flow (r = 0.92, P less than 0.01), urine flow (r = 0.75, P less than 0.01), and sodium ...
The relationship between left ventricular systolic function and congestive heart failure diagnosed by clinical criteria.
Authors: P RMarantz, J NTobin, SWassertheil-Smoller, R MSteingart, J PWexler, NBudner, LLense, JWachspress
Journal: Circulation (1988)

There is no uniformly accepted clinical definition for congestive heart failure (CHF), although criteria have been published by various groups. There is also no reference standard for CHF, although left ventricular ejection fraction (LVEF) gives a quantitative assessment of systolic function and is useful in predicting prognosis. To determine the relationship between LVEF and clinically diagnosed CHF, we compared resting LVEF determined by radionuclide ventriculography with diagnosis of CHF by clinical criteria in 407 patients, based on clinical data collected by a cardiology fellow. Of 153 patients with a low LVEF (less than or equal to 0.40), 30 (20%) met none of the criteria for CHF. Conversely, of 204 patients with normal LVEF (greater than or equal to 0.50), 105 (51%) met at least one of the criteria. We conclude that different criteria for CHF will have varying utility depending on the population being examined, and that a combination of clinical features and an objective measure of cardiac performa...
Augmentation of myocardial digoxin concentration in hemorrhagic shock.
Authors: B LLloyd, R RTaylor
Journal: Circulation (1975)

The effect of the shock state on myocardial digoxin uptake and plasma digoxin levels was examined in unanesthetized dogs following hemorrhage. Five minutes after intravenous administration of tritiated digoxin the myocardial digoxin content in animals with shock was greater than in normal animals in both left ventricle (LV) (165 plus or minus 15 (SD) ng/g vs 130 plus or minus 26 ng/g, P smaller than 0.02 and right ventricle (RV) (142 plus or minus 13 ng/g vs 111 plus or minus 22 ng/g. P smaller than 0.02) as was the plasma digoxin concentration (61.6 plus or minus 11.8 ng/ml vs 44.3 plus or minus 4.6 ng/ml, P smaller than 0.02). After one hour, in another group of dogs, the difference in myocardial concentration of digoxin between test and normal groups was even greater (LV: 213 plus or minus 26 ng/g vs 133 plus or minus 13 ng/g, P smaller than 0.001; RV: 171 plus or minus 9 ng/g vs 111 plus or minus 8 ng/g. P smaller than 0.001) despite lower plasma digoxin concentration in the test group (12.9 plus or m...
Causes of fever in outpatient Tanzanian children.
Authors: Hendry R. Sawe, Brittany L. Murray, Teri A. Reynolds
Journal: New England Journal of Medicine (2014)

To the Editor: As physicians working in the only public emergency department in Tanzania, we are acutely aware of the need for better data to guide management of febrile illness in children, as described by D’Acremont et al. (Feb. 27 issue).1 However, we question the suggestion that it is safe to send febrile children home without antimicrobial treatment. In this study, 22% of febrile children had bacterial infections, and 10.5% had malaria. Since Tanzania has limited pediatric health care capabilities, follow-up cannot be ensured, and delayed treatment can lead to severe morbidity and mortality. In addition, in the studies that the authors cite to support the withholding of antimalarial drugs, investigators used rapid diagnostic testing,2-4 which is often unavailable. In the studies that they cite to support the withholding of antibiotics, the children had respiratory symptoms,4,5 not nonspecific febrile illness. Furthermore, since most medications are available without prescription, children often receive antimicrobial drugs before they arrive at a health center; the exclusion of children with previous treatment further limits generalizability. At this time, we would hesitate to support changing clinical practice. Hendry R. Sawe, M.D.
Reply to FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer–subgroup analysis of patients with KRAS-mutated tumours in the randomised German AIO study KRK-0306
Authors: F. Pietrantonio, M.C. Garassino, V. Torri, F. de Braud
Journal: Annals of Oncology (2012)
Intravenous isosorbide dinitrate in patients with refractory pump failure and acute myocardial infarction.
Authors: BRabinowitz, ITamari, EElazar, H NNeufeld
Journal: Circulation (1982)

We studied the hemodynamic effects of isosorbide dinitrate administered by continuous i.v. infusion to 22 patients with chronic refractory pump failure and 18 with pump failure due to acute myocardial infarction. In patients with severe pump failure, i.v. ISDN markedly decreased pulmonary capillary wedge pressure (p less than 0.001), moderately increased cardiac output (p less than 0.01), and decreased systemic vascular resistance (SVR) (p less than 0.001). There were no deleterious effects on arterial pressure and heart rate. The effects obtained in acute and chronic left ventricular failure were similar. Patients with initial SVR levels lower than 1500 dyn-sec-cm-5 did not significantly increase their cardiac output (p less than 0.005). Cardiac output increased more than 25% only in patients with initial high SVR levels (greater than 2000 dyn-sec-cm(-)5). Positive correlations were found between high SVR and elevated plasma catecholamines (r = 0.53, p less than 0.05) and between the initial SVR and init...
Phenylphosphonate: a 31P-NMR indicator of extracellular pH and volume in the isolated perfused rabbit bladder.
Authors: M JFisher, P FDillon
Journal: Circulation Research (1987)

31P-NMR has been used extensively to estimate intracellular pH. It also can be used to measure extracellular pH and volume when an NMR-detectable extracellular phosphorous probe is used. Phosphonic acids have been suggested as useful 31P-NMR extracellular markers. The present study was designed to assess the utility of phenylphosphonic acid (PPA) as a 31P-NMR extracellular marker in perfused smooth muscle. Rabbit bladder strips were exposed to PPA concentrations of 1-20 mM. Tension development in response to maximal carbachol challenges (10 microM) was independent of PPA concentration. Addition of PPA (6 mM) to the perfusate supplying the isolated resting rabbit bladder had no effect on 31P-NMR-detectable phosphatic compounds. PPA's resonance frequency was distinctly downfield from endogenous phosphates and demonstrated a pH-dependent chemical shift of +/- 1.12 ppm/pH unit over the range of 6.4 to 7.6 with a pK' of 7.09 at 23 degrees C. The time courses for washing PPA in and out of the resting bladder we...
Delineation of determinants of left ventricular early filling. Saline versus blood infusion.
Authors: MCourtois, C JMechem, BBarzilai, FGutierrez, P ALudbrook
Journal: Circulation (1994)

BACKGROUNDLeft atrial pressure (LAP) is often believed to play a dominant role in the determination of left ventricular (LV) early diastolic filling. In a previous study we found no significant relation between LAP and LV early filling velocity (E) but found instead a relation between E and two determinants of LV myocardial shortening (contractility and afterload). To determine if such disparate results may be related to the data ranges of the independent variables in a given population of animals, we took advantage of the differential hemodynamic effects of two modes of volume expansion: saline and whole blood.METHODS AND RESULTSEighteen closed-chest anesthetized dogs were instrumented with micromanometers for measurement of LV, left atrial, and aortic pressures. LV volumes were obtained with use of contrast ventriculography, pressures by micromanometry, and transmitral flow-velocity by Doppler echocardiography. After obtaining baseline measurements, group 1 (n = 9) received rapid infusion of 500 to 650 ...
Methylene blue reverses endotoxin-induced hypotension.
Authors: J FKeaney, J CPuyana, SFrancis, J FLoscalzo, J SStamler, JLoscalzo
Journal: Circulation Research (1994)

Hypotension in septic shock is a reflection of unregulated nitric oxide (NO) production and vascular smooth muscle guanylyl cyclase activation. We examined the effect of methylene blue on lipopolysaccharide (LPS)-induced shock in anesthetized rabbits. Shock was induced with 150 micrograms/kg LPS after measurement of mean arterial pressure, platelet cGMP, and total plasma NO (nitrogen monoxide+S-nitrosothiol) content. Measurements were repeated before and after the intravenous administration of 1, 5, and 10 mg/kg methylene blue in response to a 55% reduction in mean arterial pressure. At baseline, mean +/- SEM arterial pressure was 88 +/- 3 mm Hg, which fell to 51 +/- 3 mm Hg after LPS (P < .05). Methylene blue at doses of 1, 5, and 10 mg/kg produced a prompt dose-dependent increase in mean arterial pressure to 69 +/- 2, 77 +/- 3, and 81 +/- 2 mm Hg, respectively (P < .05 versus mean arterial pressure after LPS) in association with normalization of plasma total NO content (P < .05); however, methylene blue...
A hemodynamic and Doppler echocardiographic study of ventricular function in long-term cardiac allograft recipients. Etiology and prognosis of restrictive-constrictive physiology.
Authors: H AValantine, C PAppleton, L KHatle, S AHunt, M EBillingham, N EShumway, E BStinson, R LPopp
Journal: Circulation (1989)

Conventional hemodynamic measurements and Doppler echocardiography were used to assess ventricular physiology of the human cardiac allograft and to examine the influence of pertinent clinical factors on chronic myocardial performance. Sixty-four patients (18-55 years old; mean, 39 years) undergoing routine annual hemodynamic assessment were studied. Blood-flow velocity properties across the mitral, tricuspid, and aortic valves were analyzed from Doppler ultrasound recordings. Ten of these patients had elevated diastolic pressures associated with a sharp early diastolic dip followed by an exaggerated and abrupt rise in pressure, consistent with restrictive-constrictive ventricular physiology. Left ventricular dP/dt and stroke volume were lower in these patients compared with the other 54 patients. Doppler echocardiographic indexes of left ventricular filling and ejection in these 10 patients differed significantly. Isovolumic relaxation time and pressure half-time were shorter, peak early mitral and tricus...
Chronic anal ulceration due to nicorandil
Authors: R. Malik, C. Clark, R. Blair, F.C.G. Shaffrali, S. Holmes
Journal: British Journal of Dermatology (2005)

Sir, We were interested to read the case of nicorandil‐induced anal ulceration described by Passeron et al.1 We too have encountered this unusual drug reaction and, like the case described by Passeron et al. the cause of the ulceration went unrecognized for many months in one patient. Patient 1. A 64‐year‐old woman had long‐standing essential hypertension and known ischaemic heart disease (IHD). She was commenced on nicorandil 10 mg twice daily for angina and the dosage was increased to 20 mg twice daily. The drug was well tolerated for 3 years. Subsequently, the dose of nicorandil was increased to 30 mg twice daily and within 6–8 weeks she developed large areas of ulceration affecting the vulva, perineum and perianal skin (Fig. 1). She was managed by the colorectal surgeons but the ulceration progressed despite conservative treatment. Multiple biopsies showed a nonspecific chronic inflammatory infiltrate within the dermis. There was no evidence of granulomata, malignancy or vasculitis.
Basic structure-function relations of the epicardial coronary vascular tree. Basis of quantitative coronary arteriography for diffuse coronary artery disease.
Authors: CSeiler, R LKirkeeide, K LGould
Journal: Circulation (1992)

BACKGROUNDQuantitative coronary arteriography has been validated for stenotic segments of coronary arteries. However, it does not currently account for diffuse coronary artery disease, because the normal size of the coronary artery for its distal myocardial bed size is not known and cannot be measured directly with diffuse involvement of the artery.METHODS AND RESULTSFrom clinical coronary arteriograms of 12 patients without coronary artery disease (group 1) and in 17 patients with coronary artery disease (group 2), we determined by quantitative coronary arteriography 1) the relations among measured coronary artery cross-sectional lumen area, summed distal branch lengths, and regional myocardial mass distal to each point in each coronary artery; 2) the ratio of coronary artery lumen area between parent and daughter vessels at 50 bifurcations; and 3) which of three different theoretical physical principles could underlie the tree structure of the human coronary artery system, by comparing the coronary arte...
The PRISMA 2020 statement: An updated guideline for reporting systematic reviews
Authors: Matthew J. Page, Joanne E. McKenzie, Patrick M. Bossuyt, Isabelle Boutron, Tammy C. Hoffmann, Cynthia D. Mulrow, Larissa Shamseer, Jennifer M. Tetzlaff, Elie A. Akl, Sue E. Brennan, Roger Chou, Julie Glanville, Jeremy M. Grimshaw, Asbjørn Hróbjartsson, Manoj M. Lalu, Tianjing Li, Elizabeth W. Loder, Evan Mayo-Wilson, Steve McDonald, Luke A. McGuinness, Lesley A. Stewart, James Thomas, Andrea C. Tricco, Vivian A. Welch, Penny Whiting, David Moher
Journal: International Journal of Surgery (2021)

The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement, published in 2009, was designed to help systematic reviewers transparently report why the review was done, what the authors did, and what they found. Over the past decade, advances in systematic review methodology and terminology have necessitated an update to the guideline. The PRISMA 2020 statement replaces the 2009 statement and includes new reporting guidance that reflects advances in methods to identify, select, appraise, and synthesise studies. The structure and presentation of the items have been modified to facilitate implementation. In this article, we present the PRISMA 2020 27-item checklist, an expanded checklist that details reporting recommendations for each item, the PRISMA 2020 abstract checklist, and the revised flow diagrams for original and updated reviews.
ACUTE DILATATION OF THE STOMACH.
Journal: JAMA (1902)

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