tbuckley/cabot-search huggingface dataset:
INTERMITTENT HYPERTHERMIA OF SEVEN YEARS' DURATION
Authors: Edgar V. Allen
Journal: Annals of Internal Medicine (1937)

Case Reports1 February 1937INTERMITTENT HYPERTHERMIA OF SEVEN YEARS' DURATIONEDGAR V. ALLEN, M.D., F.A.C.P.EDGAR V. ALLEN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-8-1204 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA mechanical engineer, 38 years old, was admitted to the Clinic September 27, 1935, complaining of attacks of fever during a period of seven years. The patient was born in Dayton, Ohio, and moved to southern California at the age of eight years. He had never been in the tropics, in South or Central America, or in Mexico other than in parts within 50 miles of the California border. He had had measles and whooping cough as a child, and while serving in the Navy in 1918 had had measles complicated by lobar pneumonia.Between the ages of 23 and...Bibliography1. REIMANN HA: Habitual hyperthermia, Jr. Am. Med. Assoc., 1932, xcix, 1860-1862. CrossrefGoogle Scholar2. REIMANN HA: Habitual hyperthermia: a clinical study of four cases of long continued low grade fever, Arch. Int. Med., 1935, lv, 792-808. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota*Read before the meeting of the Minnesota Society of Internal Medicine, Duluth, Minnesota, June 6, 1936.From the Division of Medicine, The Mayo Clinic, Rochester, Minnesota. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPeriodic fever 1 February 1937Volume 10, Issue 8Page: 1204-1211KeywordsEngineersFeversHyperthermiaMeaslesPneumonia ePublished: 1 December 2008 Issue Published: 1 February 1937 PDF downloadLoading ...
Lack of the t(2;5) or other mutations resulting in expression of anaplastic lymphoma kinase catalytic domain in CD30+ primary cutaneous lymphoproliferative disorders and Hodgkin's disease
Authors: GS Wood, DL Hardman, R Boni, R Dummer, YH Kim, BR Smoller, M Takeshita, M Kikuchi, G Burg
Journal: Blood (1996)
Abstract 13143: KvLQT1 Autoantibodies Accelerate Repolarization and Increase Susceptibility to Ventricular Tachyarrhythmias in an Experimental Model
Authors: Jin Li, Ange Maguy, Patrick Vigneault, Dierk Thomas, Stanley Nattel
Journal: Circulation (2013)

Introduction: Emerging data indicate the potential involvement of autoantibodies in the pathogenesis of cardiac arrhythmias. In a previous clinical study enrolling patients with dilated cardiomyopa...
Abstract MP68: Common Genetic Variants in the Endothelial System Predict Blood Pressure Response to Sodium Intake: The GenSalt Study
Authors: Maria D Defago, Dongfeng Gu, James E Hixson, Lawrence C Shimmin, Treva K Rice, Charles C Gu, Cashell E Jaquish, Depei Liu, Jiang He, Tanika N Kelly
Journal: Circulation (2013)

Recent evidence suggests that the role of the endothelial system in blood pressure (BP) regulation may in part be mediated by endothelial nitric oxide response to extracellular sodium concentration...
NPM-ALK mediates phosphorylation of MSH2 at tyrosine 238, creating a functional deficiency in MSH2 and the loss of mismatch repair
Authors: K M Bone, P Wang, F Wu, C Wu, L Li, J T Bacani, S E Andrew, R Lai
Journal: Blood Cancer Journal (2015)

Abstract The vast majority of anaplastic lymphoma kinase-positive anaplastic large cell lymphoma (ALK+ALCL) tumors express the characteristic oncogenic fusion protein NPM-ALK, which mediates tumorigenesis by exerting its constitutive tyrosine kinase activity on various substrates. We recently identified MSH2, a protein central to DNA mismatch repair (MMR), as a novel binding partner and phosphorylation substrate of NPM-ALK. Here, using liquid chromatography–mass spectrometry, we report for the first time that MSH2 is phosphorylated by NPM-ALK at a specific residue, tyrosine 238. Using GP293 cells transfected with NPM-ALK, we confirmed that the MSH2 Y238F mutant is not tyrosine phosphorylated. Furthermore, transfection of MSH2 Y238F into these cells substantially decreased the tyrosine phosphorylation of endogenous MSH2. Importantly, gene transfection of MSH2 Y238F abrogated the binding of NPM-ALK with endogenous MSH2, re-established the dimerization of MSH2:MSH6 and restored the sensitivity to DNA mismatch-inducing drugs, indicative of MMR return. Parallel findings were observed in two ALK+ALCL cell lines, Karpas 299 and SUP-M2. In addition, we found that enforced expression of MSH2 Y238F into ALK+ALCL cells alone was sufficient to induce spontaneous apoptosis. In conclusion, our findings have identified NPM-ALK-induced phosphorylation of MSH2 at Y238 as a crucial event in suppressing MMR. Our studies have provided novel insights into the mechanism by which oncogenic tyrosine kinases disrupt MMR.
Abstract 1893: Inducible Ischemia is Predictive for Functional Improvement and Associated with Reduced Mortality in Patients with Chronic Ischemic Heart Failure Receiving Intracoronary Progenitor Cell Therapy
Authors: Maria N Bellera Gotarda, Ulrich Fischer-Rasokat, Florian H Seeger, Jorg Honold, Volker Schachinger, Stephan Fichtlscherer, Stefanie Dimmeler, Andreas M Zeiher, Birgit Assmus
Journal: Circulation (2008)

Intracoronary infusion of bone marrow-derived progenitor cells (BMC) was shown to be associated with modestly improved cardiac function in patients (pts) with chronic post-infarction heart failure ...
The Biological Effects of Laser Radiation
Authors: Martin S. Litwin, Donald H. Glew
Journal: JAMA (1964)

THE NECESSARY CONDITIONS for a quantum- radiation generator were first postulated by V. A. Fabrikant in his doctoral dissertation published by the Lebedev Institute in 1939. 1 Actual construction of the first molecular oscillator or maser ( M icrowave A mplification by the S timulated E mission of R adiation) was reported by Gordon and associates in 1954. 2 In 1958, Schawlow and Townes 3 further demonstrated the feasibility of extending the maser principle to shorter wavelengths in the visible light spectrum. In 1960, Maiman 4 succeeded in inducing stimulated emission in a ruby crystal. This visible light or optical maser utilized the principle of L ight A mplification by the S timulated E mission of R adiation ( laser ).  Since Maiman's original work, extensive and concentrated research has resulted in the development of other types of laser crystals and other types of lasers, ie, the gaseous continuous wave or CW laser
Abstract 8767: Reduction of AF Recurrences after Pulmonary Vein Isolation Using Adenosine Triphosphate with a Sufficient Observation Period
Authors: Shingo Maeda, Yasuteru Yamauchi, Hiroyuki Okada, Susumu Tao, Nobuyuki Kagiyama, Takaki Naito, Tetsuo Yamaguchi, Nobuhiro Hara, Yuji Konishi, Tomoyuki Umemoto, Takamichi Miyamoto, Tohru Obayashi, Kenzo Hirao, Mitsuaki Isobe
Journal: Circulation (2011)

Background: It is well known that additional radiofrequency (RF) applications to eliminate transient pulmonary vein (PV) reconnections induced by adenosine triphosphate (ATP) lead to a reduced recurrence of atrial fibrillation (AF) after PV isolation (PVI). However, no studies have explored the utility of ATP with a sufficient observation period. Methods: Of 322 consecutive patients (81 female; mean age 62 ± 11 years) with paroxysmal (PAF) or chronic AF (CAF) that underwent a PVI procedure, 222 had PAF, and 100 CAF. All patients received an extensive PVI procedure, and the CAF patient received an additional left atrial ablation. After the procedures, all patients underwent a right cavotricuspid isthmus ablation during the observation period and all received 20mg of ATP to assess for any dormant PV conduction. If the patients had reconnections of the PVs, additional RF energy was delivered till no reconnections were observed during the ATP injections. Results: Forty six gaps (14%) were observed after the observation period, but 69 transient gaps (21%) were recorded during the ATP injections. All transient PV reconnection gaps were abolished by additional RF applications. During a mean follow-up period of 12 ± 5 months, recurrences of AF were observed in 43 patients (26 in PAF patients, 17 in CAF patients). In patients with recurrent AF (group-R), the observation period was significantly shorter than on those without recurrent AF (group-S) (group-R vs. group-S = 17 ± 12 vs. 26 ± 17 min, P &lt; 0.01, PAF patients: 18 ± 14 vs. 26 ± 17 min, P &lt; 0.05, CAF patients: 17 ± 9 vs. 25 ± 15 min, P &lt; 0.05, respectively). There were no significant differences in the left atrial diameter (group-R vs. group-S = 37 ± 6 vs. 39 ± 8 mm, P = NS) between group-R and group-S. Further, there were no significant differences in the other parameters between the two groups. Conclusion: The results of this study demonstrate that remapping more than 25 minutes after the PVI was efficient for finding recurrence gaps, similar to with ATP injections. A sufficient observation period and the use of ATP may be useful methods to reduce AF recurrences after PVI in both PAF and CAF patients.
Identifying lithium-responsive bipolar depressed patients using nuclear magnetic resonance
Authors: J Rosenthal, A Strauss, L Minkoff, A Winston
Journal: American Journal of Psychiatry (1986)

Proton T1 relaxation times of red blood cells were significantly higher in six bipolar depressed patients than in matched normal control subjects before lithium treatment. Times decreased in five of the six patients following 1 week of lithium therapy.
AG-221, an Oral, Selective, First-in-Class, Potent Inhibitor of the IDH2 Mutant Metabolic Enzyme, Induces Durable Remissions in a Phase I Study in Patients with IDH2 Mutation Positive Advanced Hematologic Malignancies
Authors: Eytan M. Stein, Jessica K Altman, Robert Collins, Daniel J DeAngelo, Amir T Fathi, Ian Flinn, Arthur Frankel, Ross L Levine, Bruno C Medeiros, Manish Patel, Daniel A Pollyea, Gail J. Roboz, Richard M Stone, Ronan T Swords, Martin S. Tallman, Sam Agresta, Bin Fan, Hua Yang, Katharine Yen, Stéphane de Botton
Journal: Blood (2014)
Two karyotypically independent leukemic clones with the t(8;21) and 11q23 translocation in acute myeloblastic leukemia at relapse [published erratum appears in Blood 1989 Aug 15;74(3):1180]
Authors: Y Hayashi, SC Raimondi, FG Behm, VM Santana, DK Kalwinsky, CH Pui, J Jr Mirro, DL Williams
Journal: Blood (1989)
Continuing medical education
Authors: T. Richards
Journal: BMJ (1998)

Medical education is unfit for the millennium. Professional conservatism, inertia, and poor leadership have left it struggling to cope with rapidly changing health care systems. Those universities that have adopted new educational programmes may dispute this, but globally they are in a minority and their experiences have mostly not been evaluated or well disseminated. Too many education programmes at all levels continue to churn out “time honoured” material, present it boringly, and assess its absorption predominantly by written tests. Too few train doctors, both new and established, to acquire the skills that the new trends in health care demand.

Adult learning theory holds that a key element of good teaching is the ability to stimulate self learning. This message has been accepted at medical undergraduate level, where many universities have introduced variations on problem based learning curriculums. Continuing medical education has, however, lagged behind. More emphasis has been placed on quantity than quality, despite the fact that ever more credence is being given to the role of continuing medical education in maintaining professional standards.

In …
Comparison of Radiofrequency Catheter Ablation of Drivers and Circumferential Pulmonary Vein Isolation in Atrial Fibrillation
Authors: Felipe Atienza, Jesús Almendral, José Miguel Ormaetxe, Ángel Moya, Jesús Daniel Martínez-Alday, Antonio Hernández-Madrid, Eduardo Castellanos, Fernando Arribas, Miguel Ángel Arias, Luis Tercedor, Rafael Peinado, Maria Fe Arcocha, Mercedes Ortiz, Nieves Martínez-Alzamora, Ángel Arenal, Francisco Fernández-Avilés, José Jalife
Journal: Journal of the American College of Cardiology (2014)
Assessing aggression in psychiatric inpatients
Authors: D. Yeomans
Journal: BMJ (2000)

Editor—Carrying out a risk assessment can be risky. Doctors should ask patients if they are carrying weapons only if they can safely cope with the immediate production of a weapon. Doctors must consider their own safety and that of the patient, relatives, and colleagues. Sanders et al recommended inquiry into the full range of aggressive ideation but issued no warning about how dangerous this can be.1 They found that one in 20 patients admitted to a psychiatric hospital in Middlesbrough regularly carried weapons. Some patients will produce their weapon on inquiry, and a few may be prepared to use it.

I have been treated to demonstrations of knives, scissors, a machete, and a (replica) gun. In most cases I had arranged for others to be present before asking about weapons, and the situations were managed safely. Not all my colleagues have been so fortunate. The staff of psychiatric wards usually have training and experience in the management of violence. They can also respond quickly to an emergency involving a weapon on the ward. Doctors and nurses who see patients at home or in clinics rarely have such support available unless they have made specific arrangements in advance. It is therefore advisable to organise support before asking about weapons. This support could be a visit with a colleague, or a safer venue such as the ward in preference to a clinic. With good back up and an understanding of the patient's mental state, a handover of most weapons can be instigated with minimal risk to all concerned.

The method employed by Sanders et al compared a semistructured interview about risks with case note records of aggressive ideation. It is not clear if these were medical, nursing, or multidisciplinary records. A similar study in a psychiatric hospital by Harwood and Yeomans showed that a risk interview found more evidence of risk of violence than either medical or nursing records alone.2 If the medical and nursing records were combined, however, the level of routine risk recording was better and approached the quality of the systematic interview. This paper also found that risk assessments were carried out more frequently when there was a regularly reviewed standard for risk assessment audits in place and an effective audit system to back it up.
Pandemic influenza A(H1N1) 2009 vaccines in the European Union
Authors: K Johansen, A Nicoll, B  C Ciancio, P Kramarz
Journal: Eurosurveillance (2009)

Pandemic vaccines from four manufacturers are now available for use within the European Union (EU). Use of these vaccines will protect individuals and reduce the impact on health services to more manageable levels. The majority of the severely ill will be from known risk groups and the best strategy will be to start vaccinating in line with the recommendation from the European Union Health Security Committee prioritizing adults and children with chronic conditions, pregnant women and healthcare workers. The composition of authorized vaccines is reviewed in this article. The vaccine strain in all authorized pandemic vaccines worldwide is based on the same initial isolate of influenza A/California/7/2009 (H1N1)v but the vaccines differ in conditions for virus propagation, antigen preparation, antigen content and whether they are adjuvanted or not. The vaccines are likely to be effective since no significant genetic or antigenic drift has occurred and there are already mechanisms for estimating clinical effectiveness. Influenza vaccines have good safety records and no safety concerns have so far been encountered with any of the vaccines developed. However, special mechanisms have been devised for the early detection and rigorous investigation of possible significant side effects in Europe through post-marketing surveillance and analysis. Delivery of the vaccines to the risk groups will pose difficulties where those with chronic illnesses are not readily identifiable to the healthcare services. There is considerable scope for European added value through Member States with excess vaccines making them available to other states.
The norepinephrine-to-epinephrine ratio in patients with a history of suicide attempts
Authors: R B Ostroff, E Giller, L Harkness, J Mason
Journal: American Journal of Psychiatry (1985)

Norepinephrine and epinephrine were measured serially in 24-hour urine collections from 99 male psychiatric inpatients with mixed diagnoses. The group was blindly divided into those with a previous history of at least one suicide attempt (N = 38) and those without such a history (N = 61). The ratio of norepinephrine-to-epinephrine levels was significantly lower in the group with a history of suicide attempts. The authors discuss the possibility that a low norepinephrine-to-epinephrine ratio is a risk factor for suicidal behavior.
Smoke: A Global History of Smoking
Authors: Michael Neve
Journal: BMJ (2005)

T his remarkable collection of over 30 essays makes its first impact for two reasons. Firstly, it is beautifully produced and profusely illustrated, while being marketed at a reasonable price. The publishers deserve praise for this increasingly rare event in hardback publishing. Secondly—and one must take this to be an editorial decision—the focus of the collection is the history, not of tobacco or opium, but of smoke and smoking. This simple manoeuvre opens up what can only be called a cultural universe, one with its origins in the earliest known history of humankind and which takes us right up to current debates about very modern objects and their uses: the cigarette and its alleged dangers or the recent fashion for smoking rocks of cocaine, now of course called “crack.”

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Abstract 10677: Dapagliflozin in Patients With Type 2 Diabetes and Established Cardiovascular Disease: Hypotension and Volume-related Safety
Authors: Tjerk W de Bruin, Lawrence A Leiter, William T Cefalu, Ingrid Gause-Nilsson, Eva Johnsson, Shamik J Parikh
Journal: Circulation (2013)

Background: Dapagliflozin (DAPA), a selective SGLT2 inhibitor that causes increased urinary glucose excretion and mild osmotic diuresis, is a compound for treatment of type 2 diabetes mellitus (T2DM). DAPA 10 mg/d vs placebo (PBO) add-on therapy to usual care was assessed in 2 studies in inadequately controlled T2DM patients (HbA1c 7.0%-10.0%) with established cardiovascular disease (Study [ST] 1: NCT01031680, N=922; ST2: NCT01042977, N=964). Published results showed greater reductions in HbA1c, weight, and systolic blood pressure with DAPA vs PBO and that DAPA was well tolerated over 52 wks. We present volume-related safety results from these studies. Methods: Patients in both randomized studies received PBO or DAPA 10 mg added to a stable antidiabetic and antihypertensive background regimen. Patients were stratified by age <65 or ≥65 y, insulin use, and time from the most recent qualifying CV event. A prespecified history of hypertension was an inclusion criterion for ST1 and was present in 93% of patie...
Abstract 16011: Potential Protective Effects of Myeloid and Plasmacytoid Dendritic Cells in Dilated Cardiomyopathy
Authors: Rudin Pistulli, Stefanie Drobnik, Daniel Kretzschmar, Christian Jung, Michael Fritzenwanger, Gita Mall, Hans R Figulla, Atilla Yilmaz
Journal: Circulation (2011)

BACKGROUND: Dilated cardiomyopathy (DCM) is frequently the result of myocardial viral infection leading to chronic heart failure. The immunomodulating role of dendritic cells (DC) in heart muscle d...
Preliminary Evidence That ODSH (2-O, 3-O Desulfated Heparin) Is Safe and Enhances Count Recovery in Patients Treated with Intensive Therapy for Acute Myeloid Leukemia – Results of a Pilot Study
Authors: Tibor J. Kovacsovics, Alice Mims, Mohamed E Salama, Jeremy M Pantin, Michael W. Deininger, Thomas P Kennedy, Linda M Bavisotto, Kenneth M Boucher, Stephen G Marcus, Paul J Shami
Journal: Blood (2014)
Overview: maintenance therapy in psychiatry: I. Schizophrenia
Authors: John M. Davis
Journal: American Journal of Psychiatry (1975)

Hospital psychiatry has evolved from long-term "treatment" programs that were primarily custodial to the successful pharmacological treatment of acute psychotic episodes. Unfortunately, many patients still return to the hospital with relapses. This so-called revolving door syndrome draws attention to the critical importance of preventing as well as treating acute episodes. In the first part of this overview, the author reviews the clinical literature on prophylactic treatment of schizophrenia with maintenance antipsychotic drugs. The second part will review the literature on prophylactic treatment of affective disorders with lithium and tricyclics. In the opinion of the author these drugs provide the potential for truly preventive psychiatry.
Ignoring urinary incontinence may reduce long term satisfaction
Authors: C J Kelleher
Journal: BMJ (1995)

after extensive division of ahesions she was found to have moderate diverticular disease of the sigmoid colon with a loop stuck to the left posterolateral aspect of the uterus forming the fistulous communication.Given the degree of adhesions and the anatomy, she underwent a subtotal hysterectomy and oversewing of the colonic defect.Apart from a minor wound infection the remainder of her recovery was uneventful.Presumably the fistula resulted from trauma arising from the conduction of diathermy current during the endometrial ablation.While the introduction of minimally invasive but equiefficacious hysteroscopic techniques should be encouraged, serious complications may still arise.
DIABETES MELLITUS AND ATHEROSCLEROSIS
Authors: Haruo Nishimura
Journal: JAMA (1967)

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