Low-Molecular-Weight Heparin for Women With Unexplained Recurrent Pregnancy Loss
Authors: Ekkehard Schleussner, David Petroff
Journal: Annals of Internal Medicine (2015)

Letters15 September 2015Low-Molecular-Weight Heparin for Women With Unexplained Recurrent Pregnancy LossEkkehard Schleussner, MD, PhD and David Petroff, PhDEkkehard Schleussner, MD, PhDFrom Friedrich Schiller University Hospital, Jena, Germany; and University of Leipzig, Leipzig, Germany.Search for more papers by this author and David Petroff, PhDFrom Friedrich Schiller University Hospital, Jena, Germany; and University of Leipzig, Leipzig, Germany.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-5137-3 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Ms. Patil and colleagues propose looking at MPs to assess risk. This interesting approach was not well-established when our trial was designed, but we certainly agree that research in that direction should be followed.Drs. Pasquier and de Saint Martin note that LMWH does not increase live-birth rates in the populations being considered and propose exploring specific new avenues. They remark that the women in our trial were "at low risk for subsequent pregnancy loss" because the mean week of gestation at inclusion was thought to be high and the proportion of women with more than 2 previous ...References1. Clark P, Walker ID, Langhorne P, Crichton L, Thomson A, Greaves M, et al; Scottish Pregnancy Intervention Study (SPIN) collaborators.. SPIN (Scottish Pregnancy Intervention) study: a multicenter, randomized controlled trial of low-molecular-weight heparin and low-dose aspirin in women with recurrent miscarriage. Blood. 2010;115:4162-7. [PMID: 20237316] doi:10.1182/blood-2010-01-267252 CrossrefMedlineGoogle Scholar2. Kaandorp SP, Goddijn M, van der Post JA, Hutten BA, Verhoeve HR, Hamulyák K, et al. Aspirin plus heparin or aspirin alone in women with recurrent miscarriage. N Engl J Med. 2010;362:1586-96. [PMID: 20335572] doi:10.1056/NEJMoa1000641 CrossrefMedlineGoogle Scholar3. Pasquier E, de Saint Martin L, Bohec C, Chauleur C, Bretelle F, Marhic G, et al. Enoxaparin for prevention of unexplained recurrent miscarriage: a multicenter randomized double-blind placebo-controlled trial. Blood. 2015;125:2200-5. [PMID: 25636341] doi:10.1182/blood-2014-11-610857 CrossrefMedlineGoogle Scholar4. Visser J, Ulander VM, Helmerhorst FM, Lampinen K, Morin-Papunen L, Bloemenkamp KW, et al. Thromboprophylaxis for recurrent miscarriage in women with or without thrombophilia. HABENOX: a randomised multicentre trial. Thromb Haemost. 2011;105:295-301. [PMID: 21103659] doi:10.1160/TH10-05-0334 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Friedrich Schiller University Hospital, Jena, Germany; and University of Leipzig, Leipzig, Germany.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M14-2062. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoLow-Molecular-Weight Heparin for Women With Unexplained Recurrent Pregnancy Loss Ekkehard Schleussner , Gabriele Kamin , Gregor Seliger , Nina Rogenhofer , Susanne Ebner , Bettina Toth , Michael Schenk , Melanie Henes , Michael K. Bohlmann , Thorsten Fischer , Oana Brosteanu , Rupert Bauersachs , David Petroff , and Low-Molecular-Weight Heparin for Women With Unexplained Recurrent Pregnancy Loss Rucha Patil , Kanjaksha Ghosh , and Shrimati Shetty Low-Molecular-Weight Heparin for Women With Unexplained Recurrent Pregnancy Loss Elisabeth Pasquier and Luc de Saint Martin Low-Molecular-Weight Heparin for Women With Unexplained Recurrent Pregnancy Loss Rucha Patil , Kanjaksha Ghosh , and Shrimati Shetty Low-Molecular-Weight Heparin for Women With Unexplained Recurrent Pregnancy Loss Elisabeth Pasquier and Luc de Saint Martin Metrics Cited byLow molecular weight heparin or LMWH plus aspirin in the treatment of unexplained recurrent miscarriage with negative antiphospholipid antibodies: A meta-analysis of randomized controlled trialThe role of low molecular weight heparin on recurrent pregnancy loss: A systematic review and meta-analysisTherapeutische Konzepte bei habitueller AbortneigungPaternal HLA-C is a risk factor in unexplained recurrent miscarriageHLA-C antibodies in women with recurrent miscarriage suggests that antibody mediated rejection is one of the mechanisms leading to recurrent miscarriageAntithrombotic Treatment for Recurrent Miscarriage 15 September 2015Volume 163, Issue 6Page: 485KeywordsDisclosureLow molecular weight heparinMiscarriagePopulation statisticsPregnancyUltrasound imaging ePublished: 15 September 2015 Issue Published: 15 September 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...