tbuckley/cabot-search huggingface dataset:
Brain Surgery
Authors: Barry Sternlieb
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Brain death
Authors: A. G. Kalmanson
Journal: JAMA (1987)

<h3>In Reply.—</h3> We were pleased with the interest shown in our recent article. We appreciate the input of Dr Meyer and Drs Kleinman and Smith in correcting a misnomer in our article, which we had perpetuated from a prior study of preoperative risk assessment.<sup>1</sup>The ASA classification system is not related to the American Surgical Association, but rather the American Society of Anesthesiologists. Dr Meyer also objects to our comparing the means of the DrippsASA scores in Table 1 of our article. We could have instead used threshold values of the ASA scores. Regardless of the cutoff, more patients with complications exceed the threshold than patients without complications. However, two (25%) patients with postoperative ischemic events had ASA scores of 2.0 and three more had ASA scores of 3.0. Thus, all but very low threshold values for ASA scores will miss a large fraction of the patients who will
Childhood autism.
Authors: H Baker
Journal: BMJ (1970)

it be generally appreciated that some children may bear several.Little difficulty should arise in babies of the Mongolian races (of whom up to 98 % may have one or more blue spots) unless the baby is very heavily pigmented.It is the occurrence of the melanocytes in the dermis of the darker- skinned African baby that gives rise to the appearance of a bruise, and it is therefore in African children that the mistake is most likely to occur.I need hardly add it becomes very embarrassing for the practitioner if he wrongly suspects a blameless mother of ill- treating her child through mistaking this not unusual and quite harmless lesion for bruising.Nearly all Mongolian blue spots will fade within a few months of birth; exceptionally they may last for a year or longer.-Iam, etc.,
SPINAL INJURIES.
Authors: GEORGE W. KING
Journal: JAMA (1907)

Four cases of severe spinal injury have come under my observation in recent years, with about the usual result. Of this number two patients sustained a fracture in the middorsal region causing a complete crushing of the cord and as a consequence proved rapidly fatal in twenty-four and thirty-six hours, respectively. The third case (Case 1) presents some points of interest. <h3>Case 1.</h3> —A miner, aged 45, was working on a platform which gave way, precipitating him some distance. His spinal column was forced into a position of extreme flexion, being wedged in a narrow space during the 20 minutes required to free him from the débris. <h3>Symptoms.</h3> —There was considerable shock and also pain on pressure at the dorso-lumbar junction, though no evidence of displacement or of fracture of the vertebræ was found. Both sensory and motor tracts of the cord were implicated, there being complete paralysis below the
Changes in perception of immunotherapy over time among patients with advanced genitourinary cancers.
Authors: Jasnoor Malhotra, Errol James Philip, Ameish Govindarajan, Luis A Meza, Zeynep Busra Zengin, Sabrina Salgia, Ramya Muddasani, Neal Shiv Chawla, Daniela Castro, Alex Chehrazi-Raffle, Nazli Dizman, Paulo Gustavo Bergerot, Joann Hsu, Tanya B. Dorff, Sumanta K. Pal, Cristiane Decat Bergerot
Journal: Journal of Clinical Oncology (2022)

328 Background: Previous studies have shown that a significant proportion of patients with metastatic genitourinary cancers harbor inaccurate expectations of cure prior to starting treatment with immunotherapy. This study sought to compare changes in perceptions of immunotherapy reported before, and three months after, the start of therapy, as well as treatment side-effects and quality of life. Methods: This longitudinal study enrolled patients diagnosed with advanced genitourinary cancers (bladder, renal, and prostate cancers) prior to commencing immunotherapy. Patients’ perceptions were assessed prior to starting treatment (T0) and three months later (T1). Patients responded to the same survey at both time points assessing expectations of side effects, clinical outcomes (expectation of cure) and quality of life (Functional Assessment of Chronic Illness Therapy-General). Results: Among the 30 patients enrolled, the median age was 67 years old (range, 44-91); most were male (70%), married (80%), and well-educated (70%). Renal cell carcinoma (70%) was the most common form of cancer. Before starting immunotherapy (T0), patients expected (1) fewer side effects (83%) compared with other types of cancer treatment, (2) great efficacy in preventing tumor progression (90%). and (3) increased survival (90%). Notably, the expectation of cure with immunotherapy treatment had changed over time (T0 = 24% vs T1 = 7%; P = 0.001) and overall quality of life had increased (median at T0 = 90 vs T1 = 98; P = 0.01). Three months into treatment (T1), patients perceived themselves as less active (T0 = 70% vs T1 = 63%; P = 0.02), however just 16% reported severe side effects, including fatigue (10%) and diarrhea (10%). In general, patients were satisfied with the management of these side effects (60%). The majority of patients perceived improvement in their condition (50%) and were satisfied with their treatment (60%). Conclusions: This longitudinal study suggests that inaccurate perceptions of cure with immunotherapy may recede over time, with an increased proportion of patients estimating a more accurate (and lower) chance of cure after 3 months of treatment. Patients also reported improved quality of life despite these adjusted expectations of cure.
Abstract 17140: Nitric Oxide Production is Decreased in the Left Ventricle of Diabetic Subjects Undergoing Coronary Artery Bypass Grafting
Authors: Angela Kosta, Sergey V Ryzhov, Robert S Kramer, Reed D Quinn, Douglas Sawyer, Michael P Robich
Journal: Circulation (2018)

Introduction: Dysregulation of endothelial nitric oxide synthase (eNOS) and generation of nitric oxide (NO) are critical early indicators for diabetes-induced endothelial dysfunction and cardiovascular complications. We hypothesize that levels of NO production and eNOS expression by endothelial cells are decreased in DM subjects when compared to non-DM subjects. Methods: The study cohort consisted of 9 non-DM subjects and 6 DM subjects undergoing myocardial biopsy at the time of coronary artery bypass grafting surgery. The non-myocyte cell suspensions from the left ventricle (LV), right atrial appendages (RAA), and skeletal muscle (SKM) tissue were analyzed by flow cytometry to measure production of nitric oxide in subpopulations of endothelial and non-endothelial cells. Cells in suspension were incubated with DAF-2DA in the presence or absence of NO synthase inhibitor, L-NAME. Flow cytometry was used to determine production of NO in subpopulations of endothelial and non-endothelial cells from biopsies. Measurements of eNOS and phospho-eNOS (ser1177) were performed using western blot. Results: Basal Nitric oxide production was measurable in non-diabetic subjects \ in 55%, 80% and 65% of unstimulated endothelial cells obtained from RAA, LV and SKM biopsies, compared to 40%, 40%, and 66%, respectively in diabetic subjects ( P &lt; 0.02, DM vs Non-DM). No differences were found in the number of NO-producing non-endothelial cells between DM and non-DM subjects. The level of eNOS showed a trend towards decreased protein expression in DM subjects compared to non-DM. Conclusions: Generation of NO by endothelial cells and level of eNOS expression are decreased in left ventricular endothelial cells of DM patients compared to non-DM. Left ventricular biopsies can be used safely for assessment of NO dysregulation and endothelial dysfunction, and whether these can be improved with interventions targeting diabetic cardiovascular disease.
Corrigendum
Journal: British Journal of Dermatology (2021)

British Journal of DermatologyVolume 185, Issue 3 p. 686-686 CorrigendumFree Access Corrigendum This article corrects the following: British Association of Dermatologists guidelines for the management of people with cutaneous squamous cell carcinoma 2020* S.G. Keohane, J. Botting, P.G. Budny, O.M. Dolan, K. Fife, C.A. Harwood, R. Mallipeddi, J.R. Marsden, R.J. Motley, C. Newlands, C. Proby, A. Rembielak, D.N. Slater, J.A. Smithson, P. Buckley, P. Fairbrother, M. Hashme, M.F. Mohd Mustapa, L.S. Exton, , Volume 184Issue 3British Journal of Dermatology pages: 401-414 First Published online: January 18, 2021 First published: 02 September 2021 https://doi.org/10.1111/bjd.20649AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat DOI: 10.1111/bjd.20649 In this guideline by Keohane et al.,1 the wording for recommendation R26, especially the portion "very high-risk lesions, such as pT2 or greater lip cSCC" was insufficiently clear, opening it to interpretations and has caused some confusion. To clarify, advanced cSCC of the lip may overlap into the oral cavity and fall into the same risk as oral SCC. Routine ultrasound surveillance of head and neck lymph nodes is common practice for oral SCC. Therefore, the guideline development group (GDG) have amended the recommendation to make it clearer. R26 UPDATED (GPP) Do not routinely offer imaging of the draining nodal basin to people with cSCC in the absence of suspected or clinically detectable regional nodal involvement. Consider high-resolution ultrasound scan of the regional nodes in pT2 (or greater) clinically N0 cSCC of the lip due to the increased risk of occult metastasis. The GDG apologize for the confusion. Reference 1Keohane SG, Botting J, Budny PG, Dolan OM, Fife K, Harwood CA, Mallipeddi R, Marsden JR, Motley RJ, Newlands C, Proby C, Rembielak A, Slater DN, Smithson JA, Buckley P, Fairbrother P, Hashme M, Mohd Mustapa MF, Exton LS; British Association of Dermatologists’ Clinical Standards Unit. British Association of Dermatologists guidelines for the management of people with cutaneous squamous cell carcinoma 2020. Br J Dermatol 2021; 184: 401– 414. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Volume185, Issue3September 2021Pages 686-686 ReferencesRelatedInformation
Self help.
Authors: A D Gunn
Journal: BMJ (1984)

Self help"One of my clients has a daughter with Pierre Robin's syndrome and would like to be put in contact with other parents in similar circumstances"-letter in "Health Visitors' Association Yournal"' Over half a million self help groups are said to exist in the United States,2 and when the Sunday Times published its first edition of the Self Help Directory in 1975 it sold out and has since run to three editions.3The recently founded College of Health offers to its subscribers "information services on self help groups," as well as other benefits for the
Malingering
Authors: R. Good
Journal: BMJ (1942)

M[ITISI3URNA be harmful in the future when the period of present cheap money is past.Another present-day aspect of medical student life which personally I much regret is the innovation of political student societies.It is a tradition of British Medicine, as it is of the British Red Cross, that our service is independent of political creed.The doctor should be entirely impervious to political influences.His concern is with the -great essentials of birth, life, and death, which transcend all other considerations, and he should resolutely turn his back to the rival claims of political factions both at home and abroad.
Ecosystems, Public Health
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Covid-19: Antibodies after AstraZeneca and Pfizer vaccines decrease with age and are higher in women, data show
Authors: Gareth Iacobucci
Journal: BMJ (2022)

Covid-19: Antibodies after AstraZeneca and Pfizer decrease with age and are higher in women, data show Gareth Iacobucci SARS-CoV-2 antibody levels after receiving the AstraZeneca or Pfizer-BioNTech vaccine decrease with age and are higher in females and people with prior infection, show data from the Real-time Assessment of Community Transmission (React-2) study. 1 The study, led by Imperial College London, analysed self-reported results from Fortress lateral flow tests to detect antibodies in a drop of blood from a finger prick.Data were collected from 212 102 adults from January to May 2021, of whom 71 923 (33.9%) had received at least one dose of Pfizer-BioNTech and 139 067 (65.6%) at least one dose of AstraZeneca.1
Galactosaemia
Authors: P. J. N. Cox, R. J. P. Pugh
Journal: BMJ (1954)

THROMBOTIC THROMBOCYTOPENIC PURPURABxcom 613between 35 and 140 yA in diameter, but a few thrombi were seen in interlobular arterioles.The glomerular arterioles were rarely affected, but a few were found in which the thrombus -extended into the glomerular hilum; it was not possible to say whether it was the afferent or efferent arteriole that was affected.In consequence of this relative immunity of arterioles the glomeruli were nearly all normal.A remarkable degree' of atrophy was present, however, in the tubules, with ischaemic fibrosis (Fig. 2).As the ischaemia was due to venous rather than to arterial obstruc- tion, the pattern was entirely different from that seen in arteriosclerosis, and the ischaemic areas were scattered irregularly over the cortex.Most of the thrombi showed signs of organization, and invasion by spindle cells, with formation of reticulin fibrils in the more recent, while the older showed collagenous scarring.Similar thrombi were to be seen in the arterioles and venules of the hepatic portal systems.These microscopical findings are fairly typical of this disease.The two unusual features in this case are the thrombosis of venules rather than arterioles and the ischaemic fibrosis of the renal cortex.Symmers (1952) says that it is exceptional to find thrombi in venules, and that some authors claim that the supposed venules are dilated arterioles which have been misidentified.That cannot be so in the present case, as only a few of the thrombosed vessels are so far dilated as to make their identity doubtful.The relative paucity of ischaemic lesions is usually explained by the incomplete occlusion of many affected vessels.In this case, also, many vessels only seem to have been partially occluded by thrombus, but the ischaemic fibrosis is obvious.The haphazard distribution of the ischaemic areas is additional evidence that it is not mainly arterioles, that have been obstructed.
THE VITAMINS OF CEREALS
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Serum Glutamic Oxalacetic and Pyruvic Transaminases in a Case of Cardiac Arrest Resuscitated by External Cardiac Massage
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MUSCLE MURMUR
Authors: Ethan A. Gray
Journal: JAMA (1924)

<h3>To the Editor:</h3> —Muscle murmurs seem to present to the student some little difficulty in differentiation. They are confused with fine râles, not infrequently, while one student stated that what he heard as muscle murmur he had been accustomed to regard as "cog-wheel" respiration. Other students have told me that the murmur often so dominated the field that they were unable to determine the character of the sounds that they were hearing. This whole confused subject may be cleared up by the simple means of instructing the student to auscultate over other than chest muscles. Listening over the deltoid or the biceps will give a pure muscle murmur, when the arm is flexed against resistance, or, in the case of the deltoid, raised, against resistance.
Salop Infirmary
Authors: E. Burd
Journal: BMJ (1858)

JUST at the present time, when there is some discussion and much difference of opinion, as to the effects of a saccharine treatment of diabetes, the following case may not be uininter- esting.I will merely give a few of the principal details, which touch more particularly on the point at issue.M. M., aged 30, married, came under my care in the Salop Infirmary, on November 14th, 1857, suffering from diabetes mellitus in an advanced stage.She is one of a healthy family, and resides in a healthy village in North Wales, where she has been under regular medical attendance for some months.She
Radiology: Patient Load Jumps
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MASTOIDITIS
Authors: A. Dighton
Journal: BMJ (1919)

r THz Ditm collapse.Not iuieqaetly these cases exhibit pre- monitory symptoms, consisting of extreme restlessness, blanching, and increase of pulse rate, which are sufficiently definite to lead one to make sure that a tourniquet is readily available.A lesion of a main arterial trunk is almost invariably present in such cases.Experimentally, it was found th-at manipulation of a large vesse1 in a wound caused considerable variation in the general blood pressure, even if the vessel were uniajured.These cases lend support to the view that disturbance of the nervous meebanism of the vascular system may be the initial pathological factor in the production of surgical shock Amnount.The amount of blood employed was usually 600 c.cm., but amouuts of 900 to 1,200 ccm.have been injected as the condition of the patient demanded.The donor's blood pressure usually fell about 10 mm.Hg, but recovered to normal within an hour.Accidents.(a) Incampatibility has been met with on three occa- sions.In two of these transfusion was abandoned, no ill effects persisting;.they occurred early in the series, and were probably due to faulty comparison of the bloods.(These cases are not included in the series.)The third ease occurred in a patient suffering from pyaemia, and merits a dletailed note.
Manuscripts Approved for JNCI, July-August 1974
Journal: JNCI Journal of the National Cancer Institute (1974)

Manuscripts Approved for JNCI, July-August 1974 Get access JNCI: Journal of the National Cancer Institute, Volume 53, Issue 3, September 1974, Pages 899–902, https://doi.org/10.1093/jnci/53.3.899-e Published: 01 September 1974