tbuckley/cabot-search huggingface dataset:
Reductions in early-life intestinal metabolites are associated with food allergy
Authors: Kathleen Lee-Sarwar, Yih-Chieh Chen, Jessica Lasky-Su, Rachel Kelly, Robert Zeiger, George O, Leonard Bacharier, Xiaojiong Jia, Avraham Beigelman, Diane Gold, Nancy Laranjo, Supinda Bunyavanich, Augusto Litonjua, Scott Weiss, Patrick Brennan
Journal: Journal of Allergy and Clinical Immunology (2022)
Eltrombopag inhibits TET dioxygenase to contribute to hematopoietic stem cell expansion in aplastic anemia
Authors: Yihong Guan, Metis Hasipek, Dongxu Jiang, Anand D. Tiwari, Dale R. Grabowski, Simona Pagliuca, Sunisa Kongkiatkamon, Bhumika Patel, Salendra Singh, Yvonne Parker, Thomas LaFramboise, Daniel Lindner, Mikkael A. Sekeres, Omar Y. Mian, Yogen Saunthararajah, Jaroslaw P. Maciejewski, Babal K. Jha
Journal: Journal of Clinical Investigation (2022)

Eltrombopag, an FDA-approved non-peptidyl thrombopoietin receptor agonist, is clinically used for the treatment of aplastic anemia, a disease characterized by hematopoietic stem cell failure and pancytopenia, to improve platelet counts and stem cell function. Eltrombopag treatment results in a durable trilineage hematopoietic expansion in patients. Some of the eltrombopag hematopoietic activity has been attributed to its off-target effects, including iron chelation properties. However, the mechanism of action for its full spectrum of clinical effects is still poorly understood. Here, we report that eltrombopag bound to the TET2 catalytic domain and inhibited its dioxygenase activity, which was independent of its role as an iron chelator. The DNA demethylating enzyme TET2, essential for hematopoietic stem cell differentiation and lineage commitment, is frequently mutated in myeloid malignancies. Eltrombopag treatment expanded TET2-proficient normal hematopoietic stem and progenitor cells, in part because of its ability to mimic loss of TET2 with simultaneous thrombopoietin receptor activation. On the contrary, TET inhibition in TET2 mutant malignant myeloid cells prevented neoplastic clonal evolution in vitro and in vivo. This mechanism of action may offer a restorative therapeutic index and provide a scientific rationale to treat selected patients with TET2 mutant-associated or TET deficiency-associated myeloid malignancies.
Leads from the MMWR. Update: influenza activity--worldwide
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Long-Term Efficacy of Dupilumab in Patients With Asthma With and Without Comorbid Chronic Rhinosinusitis/Nasal Polyposis
Authors: Andrew Menzies-Gow, Anju Peters, Piotr Kuna, Klaus Rabe, Arman Altincatal, Yamo Deniz, Juby Jacob-Nara, Scott Nash, Benjamin Ortiz, Michel Djandji, Paul Rowe
Journal: Journal of Allergy and Clinical Immunology (2022)
Randomized Trial of Two or Five Computed Tomography Scans in the Surveillance of Patients With Stage I Nonseminomatous Germ Cell Tumors of the Testis: Medical Research Council Trial TE08, ISRCTN56475197—The National Cancer Research Institute Testis Cancer Clinical Studies Group
Authors: Gordon J. Rustin, Graham M. Mead, Sally P. Stenning, Paul A. Vasey, Nina Aass, Robert A. Huddart, Michael P. Sokal, Jonathan K. Joffe, Stephen J. Harland, Sarah J. Kirk
Journal: Journal of Clinical Oncology (2007)

Surveillance is a standard management approach for stage I nonseminomatous germ cell tumors (NSGCT). A randomized trial of two versus five computed tomography (CT) scans was performed to determine whether the number of scans influenced the proportion of patients relapsing with intermediate- or poor-prognosis disease at relapse.Patients with clinical stage I NSGCT opting for surveillance were randomly assigned to chest and abdominal CT scans at either 3 and 12 or 3, 6, 9, 12, and 24 months, with all other investigations identical in the two arms. Three of five patients were allocated to the two-scan schedule. Four hundred patients were required.Two hundred forty-seven patients were allocated to a two-scan and 167 to five-scan policy. With a median follow-up of 40 months, 37 relapses (15%) have occurred in the two-scan arm and 33 (20%) in the five-scan arm. No patients had poor prognosis at relapse, but two (0.8%) of those relapsing in the two-scan arm had intermediate prognosis compared with 1 (0.6%) in the five-scan arm, a difference of 0.2% (90% CI, -1.2% to 1.6%). No deaths have been reported.This study can rule out with 95% probability an increase in the proportion of patients relapsing with intermediate- or poor-prognosis disease of more than 1.6% if they have two rather than five CT scans as part of their surveillance protocol. CT scans at 3 and 12 months after orchidectomy should be considered a reasonable option in low-risk patients.
Pharmacokinetics and Pharmacodynamics of Neffy (1 mg) compared to EpiPen (0.3 mg) and Manual IM injection (0.3 mg) – an Integrated Analysis
Authors: Sarina Tanimoto, Michael Kaliner, Richard Lockey, Motohiro Ebisawa, Luana Pesco Koplowitz, Barry Koplowitz, Richard Lowenthal
Journal: Journal of Allergy and Clinical Immunology (2022)
Cancer Treatment During COVID-19: Resilience of Individuals With Advanced Non–Small Cell Lung Cancer Versus Community Controls
Authors: Nicole A. Arrato, Stephen B. Lo, Clarence A. Coker, Jonathan J. Covarrubias, Tessa R. Blevins, Sarah A. Reisinger, Carolyn J. Presley, Peter G. Shields, Barbara L. Andersen
Journal: Journal of the National Comprehensive Cancer Network (2022)

Among all patients with cancer, those with advanced non-small cell lung cancer (NSCLC) experience the most distress. Although new therapies are improving survival, it is unknown whether receiving immunotherapy or targeted therapy during the COVID-19 pandemic increases patients' psychological vulnerability. To meet clinical needs, knowledge of patients' COVID-19 perceptions and safety behaviors is essential. Thus, this study compared patients' psychological responses at diagnosis and during COVID-19 and compared patients with similar individuals without cancer during the same period.Patients with advanced NSCLC enrolled at diagnosis for cohort study participated (ClinicalTrials.gov identifier: NCT03199651). Those with follow-ups from April 28, 2020, through July 14, 2020 (n=76), were assessed again including COVID-19 measures. Simultaneously, community controls with similar sociodemographics and smoking histories were solicited (n=67). Measures were COVID-19 perceptions (Brief Illness Perception Questionnaire), social distancing, and depressive (Patient Health Questionnaire-9) and anxiety (Generalized Anxiety Disorder-7) symptoms. First, analyses evaluated differences in the psychological responses of patients with NSCLC at diagnosis and during COVID-19. Second, patients and controls were contrasted on COVID-19 perceptions, social distancing, and psychological symptoms.The depressive and anxious symptoms of patients with NSCLC were greater at diagnosis (P<.02) than during COVID-19, approximately 1 year later. Patients with NSCLC and controls did not differ in terms of sociodemographics, except those with NSCLC were more racially diverse and older, and had greater smoking history (P<.03). Groups did not differ regarding concern, understanding, or perceived control over COVID-19 (P>.406). Notably, controls anticipated the COVID threat would last longer, practiced more social distancing, were more concerned about family (P<.04), and reported worse psychological symptoms (P<.023). With less depression and anxiety, patients with NSCLC viewed COVID-19 as a shorter-term threat and had fewer COVID-19-related worries than did controls. For controls, COVID-19 was more salient, heightening worries and psychological symptoms.Despite multiple health stressors, patients with NSCLC demonstrated resilience when receiving cancer treatment during COVID-19. Nonetheless, this population remains psychologically vulnerable, requiring support at diagnosis and thereafter.
Biosensors and Point‐of‐Care Devices for Bacterial Detection: Rapid Diagnostics Informing Antibiotic Therapy (Adv. Healthcare Mater. 3/2022)
Authors: Ashna Gopal, Li Yan, Saima Kashif, Tasnim Munshi, Vellaisamy A. L. Roy, Nicolas H. Voelcker, Xianfeng Chen
Journal: Advanced Healthcare Materials (2022)

Antibiotic Therapy In article number 2101546, Nicolas H. Voelcker, Xianfeng Chen, and co-workers review biosensing platforms conferring high detection sensitivity and specificity, evaluating the benefits and drawbacks, discuss the factors influencing their potential as point-of-care devices, and provide insights on their translation into commercial medical devices.
Hepatitis C virus infection in children and adolescents
Authors: Giuseppe Indolfi, Philippa Easterbrook, Geoffrey Dusheiko, Manal H El-Sayed, Maureen M Jonas, Claire Thorne, Marc Bulterys, George Siberry, Nick Walsh, Mei-Hwei Chang, Tammy Meyers, Carlo Giaquinto, Stefan Wirth, Po-Lin Chan, Martina Penazzato
Journal: The Lancet. Gastroenterology & hepatology (2019)
Prosthetic failures in dental implant therapy
Authors: Irena Sailer, Duygu Karasan, Ana Todorovic, Maria Ligoutsikou, Bjarni Elvar Pjetursson
Journal: Periodontology 2000 (2022)

Both fixed and removable implant-supported prostheses are well-established methods for replacing missing teeth in partially or fully edentulous patients. Numerous systematic reviews have been performed in recent years to evaluate the survival and complication rates of implant-retained fixed dental prostheses and implant-retained overdentures, displaying high 5-year survival rates ranging from 97.1% for fixed dental prostheses to 95%-100% for implant-retained overdentures. However, the survival rates only represent the prostheses remaining in use for a defined follow-up time, and do not account for the potential prosthetic complications that may have arisen and influence the general success of the implant treatment. The most common technical complications of fixed implant-retained single crowns are crown fracture, fractures of ceramic implant abutments, and esthetic problems. The predominant technical complication at multiple-unit, implant-retained fixed dental prostheses is fracture/chipping of the veneering ceramic. Reported technical complications for implant-retained overdentures are overdenture fracture or chipping of the veneer materials, whereas mechanical complications include implant fracture, attachment failure, and attachment housing or insert complications. To reduce the risk of such failures, a comprehensive pretreatment diagnostic work-up is essential, including defining the prosthetic goal with the aid of a wax-up or set-up and the associated ideal, prosthetically oriented three-dimensional implant position. Furthermore, selection of the ideal type of prosthesis, including the respective implant components and materials, is important for clinical long-term treatment success.
Council on Pharmacy and Chemistry
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dupilumab Reduces Biomarkers of Type 2 Inflammation in Adult and Adolescent Patients With Eosinophilic Esophagitis: Results From Parts A and C of a Three-Part, Phase 3 LIBERTY EoE TREET Study
Authors: Marc Rothenberg, Ikuo Hirano, Evan Dellon, Margaret Collins, John Leung, Christoph Schlag, Alain Schoepfer, Qiong Zhao, Jennifer Maloney, Sivan Harel, Kiran Patel, Brad Shumel, Angela Khodzhayev, Ledia Goga, Juby Jacob-Nara, Yamo Deniz, Paul Rowe, Elizabeth Laws, Bola Akinlade, Leda Mannent, Nikhil Amin, Danen Cunoosamy, Jennifer Hamilton
Journal: Journal of Allergy and Clinical Immunology (2022)
Infigratinib Approved for Cholangiocarcinoma
Journal: Cancer Discovery (2021)

The FDA has approved the FGFR2 inhibitor infigratinib for patients with locally advanced or metastatic cholangiocarcinoma who have already been treated for the disease. In a phase II study, the overall response rate for the drug was 23%, and the progression-free survival was 7.3 months. About 77% of patients developed hyperphosphatemia, the most common side effect of the drug.
The role of inhibitory peptides, locally produced in the skin, in hidradenitis suppurativa
Journal: British Journal of Dermatology (2022)

Journal Article The role of inhibitory peptides, locally produced in the skin, in hidradenitis suppurativa Get access British Journal of Dermatology, Volume 186, Issue 2, 1 February 2022, Page e96, https://doi.org/10.1111/bjd.20924 Published: 01 February 2022
The Incidence of Diabetes Among 2,808,106 Veterans With and Without Recent SARS-CoV-2 Infection
Authors: Pandora L. Wander, Elliott Lowy, Lauren A. Beste, Luis Tulloch-Palomino, Anna Korpak, Alexander C. Peterson, Steven E. Kahn, Edward J. Boyko
Journal: Diabetes Care (2022)

OBJECTIVE To examine associations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection/coronavirus disease 2019 with incident diabetes. RESEARCH DESIGN AND METHODS We conducted a retrospective cohort study using Veterans Health Administration data. We defined all patients without preexisting diabetes with one or more nasal swabs positive for SARS-CoV-2 (1 March 2020–10 March 2021; n = 128,255) as exposed and those with no positive swab and one or more laboratory tests (1 March 2020–31 March 2021; n = 2,679,851) as unexposed. The index date for patients exposed was the date of first positive swab and for patients unexposed a random date during the month of the qualifying laboratory test. We fit sex-stratified logistic regression models examining associations of SARS-CoV-2 with incident diabetes within 120 days and all follow-up time through 1 June 2021. A subgroup analysis was performed among hospitalized subjects only to help equalize laboratory surveillance. RESULTS SARS-CoV-2 was associated with higher risk of incident diabetes, compared with no positive tests, among men (120 days, odds ratio [OR] 1.75 [95% CI 1.63–1.88]; all time, 1.44 [1.36–1.52]) but not women (120 days, 1.10 [0.87–1.38]; all time, 1.00 [0.84–1.19]). Among hospitalized participants, SARS-CoV-2 was associated with higher risk of diabetes at 120 days and at the end of follow-up in men (OR 1.40 [95% CI 1.24–1.58] and 1.23 [1.12–1.36], respectively) but not women (0.99 [0.59–1.67] and 0.97 [0.63–1.48]). Among all participants but not among hospitalized participants, sex ∗ SARS-CoV-2 interaction P values were &amp;lt;0.1. CONCLUSIONS SARS-CoV-2 is associated with higher risk of incident diabetes in men but not in women even after accounting for greater surveillance related to hospitalization.
Caring for the sick. An emerging industrial by-product
Authors: F. R. Abrams
Journal: JAMA (1986)

IMPRECISE use of terminology and a fuzzy focus on basic objectives have led health care provision to a position of conflicting values. "Cost containment" means money is to be saved (implicitly, regardless of consequences). "Cost efficiency" means money is to be allotted to the best advantage (often saving money, but usually over a longer time span). <h3>Confusion of Purpose</h3> Professor of Economics Uwe Reinhardt states the<i>business ethic</i>is to maximize the return on investment without breaking the law. The<i>medical ethic</i>is to relieve suffering, to prolong life (when the patient judges this to be his desire), and to make each individual physically able to pursue happiness in whatever socially acceptable way he desires. The very thing that makes American business successful in a populous land of consumers—mass production—is essentially incompatible with the aspect of medical care most Americans treasure, viz, competent personal care clearly in the interest of
VirStrain: a strain identification tool for RNA viruses
Authors: Herui Liao, Dehan Cai, Yanni Sun
Journal: Genome biology (2022)

Abstract Viruses change constantly during replication, leading to high intra-species diversity. Although many changes are neutral or deleterious, some can confer on the virus different biological properties such as better adaptability. In addition, viral genotypes often have associated metadata, such as host residence, which can help with inferring viral transmission during pandemics. Thus, subspecies analysis can provide important insights into virus characterization. Here, we present VirStrain, a tool taking short reads as input with viral strain composition as output. We rigorously test VirStrain on multiple simulated and real virus sequencing datasets. VirStrain outperforms the state-of-the-art tools in both sensitivity and accuracy.
Circadian regulation of cardiac metabolism
Authors: Lilei Zhang, Mukesh K. Jain
Journal: Journal of Clinical Investigation (2021)

Circadian rhythm evolved to allow organisms to coordinate intrinsic physiological functions in anticipation of recurring environmental changes. The importance of this coordination is exemplified by the tight temporal control of cardiac metabolism. Levels of metabolites, metabolic flux, and response to nutrients all oscillate in a time-of-day-dependent fashion. While these rhythms are affected by oscillatory behavior (feeding/fasting, wake/sleep) and neurohormonal changes, recent data have unequivocally demonstrated an intrinsic circadian regulation at the tissue and cellular level. The circadian clock - through a network of a core clock, slave clock, and effectors - exerts intricate temporal control of cardiac metabolism, which is also integrated with environmental cues. The combined anticipation and adaptability that the circadian clock enables provide maximum advantage to cardiac function. Disruption of the circadian rhythm, or dyssynchrony, leads to cardiometabolic disorders seen not only in shift workers but in most individuals in modern society. In this Review, we describe current findings on rhythmic cardiac metabolism and discuss the intricate regulation of circadian rhythm and the consequences of rhythm disruption. An in-depth understanding of the circadian biology in cardiac metabolism is critical in translating preclinical findings from nocturnal-animal models as well as in developing novel chronotherapeutic strategies.
Verdict on CS.
Journal: BMJ (1971)

portion of cases seen in Great Britain.The bronchial obstruction in these cases is attributed to the plugs of in- spissated mucus infiltrated with fungus mycelium, and bronchograms done after these plugs have cleared show varying degrees of proximal bronchiectasis but no evidence of segmental bronchial obstruction.Most cases of bronchial mucocoele appear to have been submitted to surgery either because the diagnosis was in doubt, or because the mass was increasing in size, or because on theoretical grounds subsequent infection was feared.The fact that so many of these cases are diagnosed in asymptomatic adults suggests that bronchial mucocoele does not necessarily become readily infected.Now that the radiographic features have been so clearly described, diagnosis should not usually present a great problem.More conserva- tive management might be considered, especially in those cases where regional overinflation is not severe and the mucocoele is not increasing in size.
Interpretation of Serum Protein-Bound Iodine (PBI) Values as Test of Thyroid Function
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Single-Dose Weight-Based Challenge Predicts the Minimally Effective Daily Dose of Prednisone in Hypereosinophilic Syndrome
Authors: Paneez Khoury, Abbie Bowman, Nicole Holland, JeanAnne Ware, Lauren Wetzler, Michelle Makiya, Michael Fay, Amy Klion
Journal: Journal of Allergy and Clinical Immunology (2022)
Biomarkers Commonly Associated with Urticaria Severity Do Not Correlate With Angioedema Activity Scores
Authors: Marina Sabaté Brescó, Nuria Rodriguez-Garijo, Julian Azofra, Maria Luisa Baeza Ochoa de Ocariz, Carmen D. Donado, Pere Gaig, Mar Guilarte, Valeria Herrera-Lasso RegÃ¡s, Moises Labrador-Horrillo, Anna Sala Cunill, Beatriz Veleiro, Maria Pilar Gil, Marta Ferrer
Journal: Journal of Allergy and Clinical Immunology (2022)