tbuckley/cabot-search huggingface dataset:
Abstract 3268: Natural History of Mild and Moderate Aortic Regurgitation: Worsening Severity is the Exception not the Rule
Authors: Kohei Fujimoto, Marco Di Tullio, Shunichi Homma, Roy Pizzarello, Rebecca Hahn, Linda Gillam
Journal: Circulation (2007)

Background: Prior studies have documented the rate of progression of valvular aortic stenosis and form the basis for “prophylactic” aortic valve replacement in patients with moderate aortic stenosi...
Systemic and organ-specific immune-related manifestations of COVID-19
Authors: Manuel Ramos-Casals, Pilar Brito-Zerón, Xavier Mariette
Journal: Nature Reviews Rheumatology (2021)

Immune-related manifestations are increasingly recognized conditions in patients with COVID-19, with around 3,000 cases reported worldwide comprising more than 70 different systemic and organ-specific disorders. Although the inflammation caused by SARS-CoV-2 infection is predominantly centred on the respiratory system, some patients can develop an abnormal inflammatory reaction involving extrapulmonary tissues. The signs and symptoms associated with this excessive immune response are very diverse and can resemble some autoimmune or inflammatory diseases, with the clinical phenotype that is seemingly influenced by epidemiological factors such as age, sex or ethnicity. The severity of the manifestations is also very varied, ranging from benign and self-limiting features to life-threatening systemic syndromes. Little is known about the pathogenesis of these manifestations, and some tend to emerge within the first 2 weeks of SARS-CoV-2 infection, whereas others tend to appear in a late post-infectious stage or even in asymptomatic patients. As the body of evidence comprises predominantly case series and uncontrolled studies, diagnostic and therapeutic decision-making is unsurprisingly often based on the scarcely reported experience and expert opinion. Additional studies are required to learn about the mechanisms involved in the development of these manifestations and apply that knowledge to achieve early diagnosis and the most suitable therapy.
Suggestion of a standard maneuver in cap-assisted colonoscopy: hooking and dragging maneuver
Authors: Jihwan Ko
Journal: Endoscopy (2021)

Cap-assisted colonoscopy involves the attachment of a distal transparent cap to the end of the colonoscope. This method has several advantages, such as decreasing insertion time [1] and enabling easy flattening of the mucosal folds, thus permitting visualization of the hidden polyps behind the mucosal folds [2]. However, the use of cap-assisted colonoscopy in detecting adenomas is debatable [1] [3]. Until now, although the benefits of using a clear cap have been discussed, there have been no discussions on how to use it. Therefore, this study suggests a “hooking and dragging maneuver” ([Video 1]). This maneuver involves hooking the mucosal fold with the tip of the cap, dragging the scope, scratching along the colon wall, and stretching multiple mucosal folds simultaneously ([Fig. 1]). This technique allows the visualization of multiple posterior regions of the mucosal fold at the same time, minimizing the hidden areas. Hooking points and dragging directions on the cecum ([Fig. 2]), the ascending colon ([Fig. 3]), and the hepatic flexure ([Fig. 4]) are shown.
Combination anti-PD1 and ipilimumab therapy in patients with advanced melanoma and pre-existing autoimmune disorders
Authors: Lauren J Brown, Alison Weppler, Prachi Bhave, Clara Allayous, J. Randall Patrinely, Patrick Ott, Shahneen Sandhu, Andrew Haydon, Celeste Lebbe, Douglas B Johnson, Georgina V Long, Alexander A Menzies, Matteo S Carlino
Journal: Journal for ImmunoTherapy of Cancer (2021)

Background Clinical trials of immunotherapy have excluded patients with pre-existing autoimmune disease. While the safety and efficacy of single agent ipilimumab and anti-PD1 antibodies in patients with autoimmune disease has been examined in retrospective studies, no data are available for combination therapy which has significantly higher toxicity risk. We sought to establish the safety and efficacy of combination immunotherapy for patients with advanced melanoma and pre-existing autoimmune diseases. Methods We performed a retrospective study of patients with advanced melanoma and pre-existing autoimmune disease who received combination ipilimumab and anti-PD1 at 10 international centers from March 2015 to February 2020. Data regarding the autoimmune disease, treatment, toxicity and outcomes were examined in patients. Results Of the 55 patients who received ipilimumab and anti-PD1, the median age was 63 years (range 23–83). Forty-six were treated with ipilimumab and nivolumab and nine with ipilimumab and pembrolizumab. Eighteen patients (33%) had a flare of their autoimmune disease including 4 of 7 with rheumatoid arthritis, 3 of 6 with psoriasis, 5 of 10 with inflammatory bowel disease, 3 of 19 with thyroiditis, 1 of 1 with Sjogren’s syndrome, 1 of 1 with polymyalgia and 1 of 1 with Behcet’s syndrome and psoriasis. Eight (44%) patients ceased combination therapy due to flare. Thirty-seven patients (67%) had an unrelated immune-related adverse event (irAE), and 20 (36%) ceased combination immunotherapy due to irAEs. There were no treatment-related deaths. Patients on immunosuppression (OR 4.59; p=0.03) had a higher risk of flare. The overall response rate was 55%, with 77% of responses ongoing. Median progression free survival and overall survival were 10 and 24 months, respectively. Patients on baseline immunosuppression had an overall survival of 11 months (95% CI 3.42 to 18.58) compared with 31 months without (95% CI 20.89 to 41.11, p=0.005). Conclusions In patients with pre-existing autoimmune disease, not on immunosuppression and advanced melanoma, combination ipilimumab and anti-PD1 has similar efficacy compared with previously reported trials. There is a risk of flare of pre-existing autoimmune disorders, particularly in patients with inflammatory bowel disease and rheumatologic conditions, and patients on baseline immunosuppression.
ASSOCIATION OF HEART FAILURE RISK FACTORS WITH LEFT VENTRICLE LONGITUDINAL CHANGE IN HISPANICS: THE ECHOCARDIOGRAPHIC STUDY OF LATINOS (ECHO-SOL)
Authors: Nestor Vasquez, Ayana April-Sanders, Katrina Swett, Jorge Kizer, Bharat Thyagarajan, Gregory Talavera, Sonia Ponce, Bonnie Shook-Sa, Frank Penedo, Martha Daviglus, Mayank Kansal, Jianwen Cai, Carlos Rodriguez
Journal: Journal of the American College of Cardiology (2021)
Occupational inhalant exposures and longitudinal lung function decline
Authors: Stinna Skaaby, Esben Meulengracht Flachs, Peter Lange, Vivi Schlünssen, Jacob Louis Marott, Charlotte Brauer, Yunus Çolak, Shoaib Afzal, Børge G. Nordestgaard, Steven Sadhra, Om Kurmi, Jens Peter Ellekilde Bonde
Journal: European Respiratory Journal (2021)

Background Airborne exposures at the workplace are believed to be associated with lung function decline. However, longitudinal studies are few, and results are conflicting. Methods Participants from two general population-based cohorts, the Copenhagen City Heart Study and the Copenhagen General Population Study, with at least two lung function measurements were followed for a mean of 9 years (range 3–27 years). Occupational exposure was assigned to each year of follow-up between the two lung function measurements by a job exposure matrix. Associations between mean occupational exposure per year and mean annual decline in forced expiratory volume in 1 s (FEV 1 ) were investigated using linear mixed-effects models according to cohort and time period (1976–1983 and 2003–2015). We adjusted for sex, height, weight, education, baseline FEV 1 and pack-years of smoking per year during follow-up. Results A total of 16 144 individuals were included (mean age 48 years and 43% male). Occupational exposure to mineral dusts, biological dusts, gases and fumes and a composite category was not associated with FEV 1 decline in analyses with dichotomised exposure. In analyses with an indexed measure of exposure, gases and fumes were associated with an FEV 1 change of −5.8 mL per unit per year (95% CI −10.8– −0.7 mL per unit per year) during 1976–1983, but not during 2001–2015. Conclusion In two cohorts from the Danish general population, occupational exposure to dusts, gases and fumes was not associated with excess lung function decline in recent years but might have been of importance decades ago.
Oncogenetic landscape and clinical impact of IDH1 and IDH2 mutations in T-ALL
Authors: Mathieu Simonin, Aline Schmidt, Christophe Bontoux, Marie-Émilie Dourthe, Etienne Lengliné, Guillaume P. Andrieu, Ludovic Lhermitte, Carlos Graux, Nathalie Grardel, Jean-Michel Cayuela, Françoise Huguet, Isabelle Arnoux, Stéphane Ducassou, Elizabeth Macintyre, Virginie Gandemer, Hervé Dombret, Arnaud Petit, Norbert Ifrah, André Baruchel, Nicolas Boissel, Vahid Asnafi
Journal: Journal of Hematology & Oncology (2021)

Abstract IDH1 and IDH2 mutations (IDH1/2 Mut ) are recognized as recurrent genetic alterations in acute myeloid leukemia (AML) and associated with both clinical impact and therapeutic opportunity due to the recent development of specific IDH1/2 Mut inhibitors. In T-cell acute lymphoblastic leukemia (T-ALL), their incidence and prognostic implications remain poorly reported. Our targeted next-generation sequencing approach allowed comprehensive assessment of genotype across the entire IDH1 and IDH2 locus in 1085 consecutive unselected and newly diagnosed patients with T-ALL and identified 4% of, virtually exclusive (47 of 49 patients), IDH1/2 Mut . Mutational patterns of IDH1/2 Mut in T-ALL present some specific features compared to AML. Whereas IDH2 R140Q mutation was frequent in T-ALL (25 of 51 mutations), the IDH2 R172 AML hotspot was absent. IDH2 mutations were associated with older age, an immature phenotype, more frequent RAS gain-of-function mutations and epigenetic regulator loss-of-function alterations ( DNMT3A and TET2 ). IDH2 mutations, contrary to IDH1 mutations, appeared to be an independent prognostic factor in multivariate analysis with the NOTCH1/FBXW7/RAS/PTEN classifier. IDH2 Mut were significantly associated with a high cumulative incidence of relapse and very dismal outcome, suggesting that IDH2 -mutated T-ALL cases should be identified at diagnosis in order to benefit from therapeutic intensification and/or specific IDH2 inhibitors.
Abstract 16413: The Development of Care Curves Following the Stage 1 Palliation: A Comparison of Intensive Care Among Five Centers
Authors: Francesca Sperotto, Jesse Davidson, Melissa N Smith-Parrish, Justin Elhoff, Anjuli Sinha, Joshua J BLINDER, Daniel Ehrmann, Bradley S Marino, John N Kheir
Journal: Circulation (2020)

Introduction: Comparisons of care among centers is currently limited to major endpoints, such as mortality, length of stay, or complication rates. Hypothesis: We hypothesized that comparing individual elements of intensive care over time using classical statistics and “care curves” may highlight important modifiable differences among centers. Methods: We retrospectively reviewed data of key elements of postoperative care after stage-1-palliation (S1P) among 5 US centers during 2009-2018. Minimum mandatory ventilation rate (MMVR), opioid total daily dose (TDD) and fluid balance (FB) were computed from postoperative day (POD) 0 to 28. Cox regression, mixed random effect models and growth chart-like care curves were used to analyze data variability and trajectory over time. Results: During the study period, 502 patients underwent S1P (median age 5 [IQR 3-6] days). Patients were weaned from MMV by POD 8 (IQR 5-16), with significant differences among centers (P&lt;0.001). Opioid administration peaked on POD 2 (3.7 [IQR 1.5-7.5] mg morphine equivalents/kg/day), and freedom from opioids was achieved in a median of 13 (IQR 8-25) days (P&lt;0.001 among centers). After adjusting for patient-level characteristics, center affiliation was independently predictive of time to freedom from MMV and from opioids. The median daily FB per patient was +23 (IQR -3 to +39) ml/kg/day (P&lt;0.001 among centers). Center affiliation was independently predictive of both trajectories over time and daily variation in MMVR, opioid TDD, and FB. Growth chart-like care curves can be used to visualize variation in elements over time (Fig1). Conclusions: Both “care curves” and classical statistics highlighted important modifiable differences in the elements of care among centers. MMVR, opioid TDD, and FB following S1P significantly differ even after adjusting for patient and operative factors. Care curves may be used to guide collaborative quality improvement initiatives in the intensive care unit.
CORONARY ARTERY CALCIFICATION HERALDS ADVERSE CLINICAL OUTCOMES IN PATIENTS HOSPITALIZED FOR COVID-19
Authors: Muhammad Asim Shabbir, Efstratios Koutroumpakis, Christopher Powell, Mariya Fatakdawala, Kevin Lin, Heinrich Taegtmeyer, Mikhail Torosoff, Radmila Lyubarova
Journal: Journal of the American College of Cardiology (2021)
Transdermal delivery of Chinese herbal medicine extract using dissolvable microneedles for hypertrophic scar treatment
Authors: Xiaoyu Ning, Christian Wiraja, Wan Ting Sharon Chew, Chen Fan, Chenjie Xu
Journal: Acta Pharmaceutica Sinica B (2021)

Hypertrophic scars are unfavorable skin diseases characterized by excessive collagen deposition. Although systemic treatments exist in clinic to manage hypertrophic scars, they pose significant side effects and tend to lose efficacy over prolonged applications. Traditional Chinese medicine (TCM) offers as a promising candidate to treat pathological scars. A large number of TCMs have been studied to show anti-scarring effect, however, the natural barrier of the skin impedes their penetration, lowering its therapeutic efficacy. Herein, we reported the use of dissolvable hyaluronic acid (HA) microneedles (MNs) as a vehicle to aid the transdermal delivery of therapeutic agent, a model TCM called shikonin for the treatment of hypertrophic scars. Here, shikonin was mixed with HA to make MNs with adequate mechanical strength for skin penetration, making its dosage controllable during the fabrication process. The therapeutic effect of the shikonin HA MNs was studied in vitro using HSFs and then further verified with quantitative reverse transcriptase polymerase chain reaction. Our data suggest that the shikonin HA MNs significantly reduce the viability and proliferation of the HSFs and downregulate the fibrotic-related genes (i.e., TGFβ1, FAP-α and COL1A1). Furthermore, we observed a localized therapeutic effect of the shikonin HA MNs that is beneficial for site-specific treatment.
SIGNIFICANCE OF INCIDENTAL FINDING OF AORTIC CALCIFICATION ON IMAGING
Authors: Haresh Gandhi, Vinit Singh, Mohsin Mughal, Kashyap Shah, Krunalkumar Patel, Nasreen Shaikh, Muhammad Asif, Joseph Apolinario, Shailee Patel, Peter Abaskhroun, Amulya Prakash, Ikwinder Kaur, Ajay Narayan Venkatanarayan, Doantrang Du
Journal: Journal of the American College of Cardiology (2021)
Response to Charlier et al.: Climate–Disease Feedbacks Mediated by Livestock Methane Emissions Are Plausible
Authors: Vanessa O. Ezenwa, David J. Civitello, Aimée T. Classen, Brandon T. Barton, Daniel J. Becker, Maris Brenn-White, Sharon L. Deem, Susan Kutz, Matthew Malishev, Rachel M. Penczykowski, Daniel L. Preston, J. Trevor Vannatta, Amanda M. Koltz
Journal: Trends in Ecology & Evolution (2021)
Immunotherapy as Single Treatment for Patients With NSCLC With Brain Metastases: A Systematic Review and Meta-Analysis—the META-L-BRAIN Study
Authors: Viviane Teixeira Loiola de Alencar, Marcos Pedro Guedes Camandaroba, Rafaela Pirolli, Camilla A.Z. Fogassa, Vladmir C. Cordeiro de Lima
Journal: Journal of Thoracic Oncology (2021)
Controlling Structure with Injectable Biomaterials to Better Mimic Tissue Heterogeneity and Anisotropy
Authors: Susan Babu, Filippo Albertino, Abdolrahman Omidinia Anarkoli, Laura De Laporte
Journal: Advanced Healthcare Materials (2021)

Tissue regeneration of sensitive tissues calls for injectable scaffolds, which are minimally invasive and offer minimal damage to the native tissues. However, most of these systems are inherently isotropic and do not mimic the complex hierarchically ordered nature of the native extracellular matrices. This review focuses on the different approaches developed in the past decade to bring in some form of anisotropy to the conventional injectable tissue regenerative matrices. These approaches include introduction of macroporosity, in vivo pattering to present biomolecules in a spatially and temporally controlled manner, availability of aligned domains by means of self-assembly or oriented injectable components, and in vivo bioprinting to obtain structures with features of high resolution that resembles native tissues. Toward the end of the review, different techniques to produce building blocks for the fabrication of heterogeneous injectable scaffolds are discussed. The advantages and shortcomings of each approach are discussed in detail with ideas to improve the functionality and versatility of the building blocks.
Procurement Biopsy Data Quality Limits Comparability of United States and French Deceased Donor Kidney Biopsies
Authors: S. Ali Husain, Sumit Mohan
Journal: Journal of the American Society of Nephrology (2021)

We read with great interest the excellent study by Reese et al. [1][1] quantifying missed opportunities for deceased donor kidney transplants attributable to a misplaced reliance on procurement biopsy findings during organ utilization decisions in the United States. The histologic comparison of
NORMAL RANGES OF NON-INVASIVE MYOCARDIAL WORK INDICES IN CHILDREN- RESULTS FROM A VIETNAMESE POPULATION
Authors: Thuy M.T Pham, Phuc N. Vu, Truong X. Tran, Nam H. Nguyen, Linh T.P Nguyen, Hien T.N Tu, Vien Truong, Wojciech Mazur, Cassady Palmer, Justin Tretter, Philip Levi, Vinh Pham
Journal: Journal of the American College of Cardiology (2021)
PRE-PROCEDURAL ATRIAL FIBRILLATION AND MORTALITY IN ALL-COMERS AND VETERANS AFFAIRS PATIENTS AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Aamir Twing, Helena Dickens, Nicole Cho, Fatema Nomani, Sanket Gokhale, Brody Slostad, Adhir Shroff, Elliott Groves, Mayank Kansal, Erik Simon
Journal: Journal of the American College of Cardiology (2021)
EFFECT OF TRANSCATHETER AORTIC VALVE REPLACEMENT ON EARLY CORONARY HEMODYNAMICS IN PATIENTS WITH SEVERE AORTIC STENOSIS AND CONCOMITANT CORONARY ARTERY DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Mohammad Saud Khan, Abdur Rahman Khan, Abdelmoniem Moustafa, Laura Pavlech, Omar Hyder, Peter Soukas, Marwan Saad, Herbert Aronow
Journal: Journal of the American College of Cardiology (2021)
HUMAN MILK DIET AND GROWTH IN SINGLE VENTRICLE INTERSTAGE PATIENTS: NATIONAL PEDIATRIC CARDIOLOGY - QUALITY IMPROVEMENT COLLABORATIVE DATABASE ANALYSIS
Authors: John Criscuolo, Yusuf Ansari, Linda Lambert, Aimee Parnell, Jarrod Knudson, Scott Simpson, David Brown, Divya Shakti
Journal: Journal of the American College of Cardiology (2021)
Artificial intelligence–enabled electrocardiograms for identification of patients with low ejection fraction: a pragmatic, randomized clinical trial
Authors: Xiaoxi Yao, David R. Rushlow, Jonathan W. Inselman, Rozalina G. McCoy, Thomas D. Thacher, Emma M. Behnken, Matthew E. Bernard, Steven L. Rosas, Abdulla Akfaly, Artika Misra, Paul E. Molling, Joseph S. Krien, Randy M. Foss, Barbara A. Barry, Konstantinos C. Siontis, Suraj Kapa, Patricia A. Pellikka, Francisco Lopez-Jimenez, Zachi I. Attia, Nilay D. Shah, Paul A. Friedman, Peter A. Noseworthy
Journal: Nature Medicine (2021)
John Knowles Stanley
Authors: Sian Stanley
Journal: BMJ (2021)

John Knowles Stanley was born in Cardiff on 3 March 1944 but grew up in Oswestry in north Wales. From the Boys’ High School, he moved in 1962 to Liverpool University, qualifying in 1968. After training in the Mersey region and a travelling fellowship in the USA, he was appointed consultant orthopaedic surgeon at Ormskirk and District General Hospital and Wrightington Hospital in 1979. Shortly after he had been appointed, at the age of 35, he had a myocardial infarction requiring bypass surgery. Consequently in 1984 he moved to full time hand surgery at Wrightington.

Under his leadership the unit grew exponentially, developing a particular focus on the treatment of patients with rheumatoid arthritis as well as other complex …
MULTIMODALITY APPROACH TO ASSESS STRUCTURAL CHANGES IN AORTA, A CASE OF QUESTIONABLE AORTITIS MASS
Authors: Tusharkumar Pansuriya, Hytham Rashid, Aswin Srinivasan, Syed Talha Qasmi, Syed Raza, Xianfeng Wen
Journal: Journal of the American College of Cardiology (2021)
Valerie Jill Everett
Authors: Jocelyn Everett, Harry Egdell
Journal: BMJ (2021)

Valerie Jill Everett (“Jill”) came from a family with a naval tradition and four generations of doctors. After the war her parents farmed in Kenya with Jill.

She was a mature entry to the Royal Free Hospital and went on to join the Uganda Medical Service, working in Entebbe and Fort Portal …
Mutations and thrombosis in essential thrombocythemia
Authors: Paola Guglielmelli, Naseema Gangat, Giacomo Coltro, Terra L. Lasho, Giuseppe Gaetano Loscocco, Christy M. Finke, Erika Morsia, Benedetta Sordi, Natasha Szuber, Curtis A. Hanson, Animesh Pardanani, Alessandro M. Vannucchi, Ayalew Tefferi
Journal: Blood Cancer Journal (2021)
ELCA(エキシマレーザー)のISR(ステント内再狭窄)に対する慢性期成績
Authors: 岡本慎, 南都伸介, 上松正朗, 両角隆一, 渡部徹也, 粟田政樹, 大西俊成, 飯田修, 大島英子, 南口仁, 赤堀宏州, 永田正毅
Journal: Circulation (2008)
Renal Replacement Therapy in People With and Without Diabetes in Germany, 2010–2016: An Analysis of More Than 25 Million Inhabitants
Authors: Heiner Claessen, Maria Narres, Tatjana Kvitkina, Adrian Wilk, Heiko Friedel, Christian Günster, Falk Hoffmann, Michael Koch, Karin Jandeleit-Dahm, Andrea Icks
Journal: Diabetes Care (2021)

Epidemiological studies have shown contradictory results regarding the time trend of end-stage renal disease (ESRD) in people with diabetes. This study aims to analyze the incidence of ESRD, defined as chronic renal replacement therapy (RRT), to investigate time trends among people with and without diabetes in Germany and to examine whether these patterns differ by age and sex.
Effect of High Dietary Sodium Intake in Patients With Postural Tachycardia Syndrome
Authors: Emily M. Garland, Alfredo Gamboa, Victor C. Nwazue, Jorge E. Celedonio, Sachin Y. Paranjape, Bonnie K. Black, Luis E. Okamoto, Cyndya A. Shibao, Italo Biaggioni, David Robertson, André Diedrich, William D. Dupont, Satish R. Raj
Journal: Journal of the American College of Cardiology (2021)
PULMONARY VENO-OCCLUSIVE DISEASE/PULMONARY CAPILLARY HEMANGIOMATOSIS: A LESSON LEARNED FROM AN UNSUCCESSFUL EXPERIENCE
Authors: Hiroki Nakayama, Yuki Nishimura, Junya Komatsu, Hiroki Sugane, Hayato Hosoda, Ryu-ichiro Imai, Yoko Nakaoka, Koji Nishida, Masayuki Ishida, Shu-ichi Seki, Sho-ichi Kubokawa, Kazuya Kawai, Naohisa Hamashige, Yoshinori Doi
Journal: Journal of the American College of Cardiology (2021)