tbuckley/cabot-search huggingface dataset:
Risk of nonacral cutaneous melanoma after the diagnosis of acral melanoma
Authors: Nicholas R. Kurtansky, Rachel N. Manci, Danielle M. Bello, Adewole S. Adamson, Alexander N. Shoushtari, Mackenzie R. Wehner, Charlotte E. Ariyan, Ashfaq A. Marghoob, Michael A. Marchetti, Veronica Rotemberg
Journal: British Journal of Dermatology (2022)
Acute symptoms in SARS-CoV-2 positive adolescents aged 15–18 years – Results from a Danish national cross-sectional survey study
Authors: Selina Kikkenborg Berg, Pernille Palm, Susanne Dam Nielsen, Ulrikka Nygaard, Henning Bundgaard, Camilla Rotvig, Anne Vinggaard Christensen
Journal: The Lancet Regional Health - Europe (2022)

The purpose of this study was to investigate prevalence of self-reported symptom burden during the acute phase of SARS-CoV-2 infection and associated factors including sex differences.
QIM22-203: Randomized Trial of Implementing a Clinical Decision Support Tool for Automatic Selection of Payor-Mandated Biosimilar at Time of Prescribing
Authors: Shayna Simon, Lindsey Skelton, Sherry F. Parker, Rebecca Brian, Waddah Arafat, Muhammad Shaalan Beg
Journal: Journal of the National Comprehensive Cancer Network (2022)

"QIM22-203: Randomized Trial of Implementing a Clinical Decision Support Tool for Automatic Selection of Payor-Mandated Biosimilar at Time of Prescribing" published on 31 Mar 2022 by National Comprehensive Cancer Network.
Protons for pediatric ependymoma: Where are we now?
Authors: Bernadine R Donahue, Shannon MacDonald
Journal: Neuro-Oncology (2022)

Unquestionably, one of the greatest “game-changers” in the irradiation of pediatric CNS malignancies has been the rapid development of technologies that allow for more targeted delivery of radiation therapy. Proton therapy, the oldest of these strategies, has come to the forefront due to dose distributions which allow for substantial sparing of uninvolved tissue. Ependymoma is an ideal site for the use of protons given its frequent location in the posterior fossa adjacent to eloquent structures. However, it is exactly this proximity, specifically to the brainstem, which mandates careful consideration of potential toxicity. Early reports of the use of protons for pediatric ependymoma from Loma Linda University Medical Center1 and the Francis H. Burr Proton Facility Therapy Center and Harvard Cyclotron Laboratory2 documented normal tissue sparing and disease control which compared favorably with the literature of the time. Concurrent with the advent of protons was the recognition that conformal volumes were appropriate for the irradiation of non-disseminated ependymoma, and the large body of work from St. Jude Children’s Hospital demonstrating excellent local control (LC)3 and the potential for decreased late effects4,5 informed the adoption of increasingly conformal radiotherapy (RT) fields.6 In 2013, MacDonald et al reported the results of proton treatment of 70 pediatric patients with localized ependymoma. At a median follow-up of 46 months, 3-year LC, progression-free survival (PFS), and overall survival (OS) were 83%, 76%, and 95%, respectively.7 Subsequent publications from that group and others continued to demonstrate good outcome.
PERSISTENT ATRIAL FIBRILLATION PATIENTS HAVE HIGHER ATRIAL FIBROSIS AND ARRHYTHMIA RECURRENCE
Authors: Mario Mekhael, Charbel Noujaim, Abdel Hadi El Hajjar, Yichi Zhang, Tarek Hassan Ayoub, Christopher Pottle, Chao Huang, Chan Ho Lim, Lilas Dagher, Alan Morris, Eugene G. Kholmovski, Nassir F. Marrouche
Journal: Journal of the American College of Cardiology (2022)
QUALITY AND OUTCOMES OF STEMI CARE IN MIDDLE INCOME COUNTRIES COMPARED TO HIGH INCOME COUTNRIES A META-ANALYSIS
Authors: Ahmed Hassanin, Ahmed Bendary, Abdelrahman Abushouk, Nikhil Govil, Ibragim Al-Seykal, Chengyue Jin, Srihari S. Naidu
Journal: Journal of the American College of Cardiology (2022)
PREDICTORS OF LEFT VENTRICLE EJECTION FRACTION RECOVERY IN A PREDOMINANTLY AFRICAN AMERICAN POPULATION AT A SAFETY NET HOSPITAL
Authors: Franck H. Azobou Tonleu, Martin L. Campbell, Tuoyo O. Mene-Afejuku, Stephanie Miller, Nathan Steele, Yetunde A. Fatade, Ryon L. Arrington, Alexis K. Okoh, Modele O. Ogunniyi
Journal: Journal of the American College of Cardiology (2022)
IMPACT OF RIGHT HEART CATHETERIZATION ON PRESCRIPTION PRACTICES IN HEART FAILURE: A SINGLE CENTER STUDY
Authors: Harsh Doshi, Michael Foster, Jake Rosen, Frank Fortino, Olivia Delorenzo, Doug Corsi, Jesus Eduardo Rame, Rene J. Alvarez, Alec Vishnevsky, Michael P. Savage, David L. Fischman
Journal: Journal of the American College of Cardiology (2022)
Oncolytic Orf virus licenses NK cells via cDC1 to activate innate and adaptive antitumor mechanisms and extends survival in a murine model of late-stage ovarian cancer
Authors: Jacob P van Vloten, Kathy Matuszewska, Mark A A Minow, Jessica A Minott, Lisa A Santry, Madison Pereira, Ashley A Stegelmeier, Thomas M McAusland, Elaine M Klafuric, Khalil Karimi, Joseph Colasanti, D Grant McFadden, James J Petrik, Byram W Bridle, Sarah K Wootton
Journal: Journal for ImmunoTherapy of Cancer (2022)

Background Novel therapies are needed to improve outcomes for women diagnosed with ovarian cancer. Oncolytic viruses are multifunctional immunotherapeutic biologics that preferentially infect cancer cells and stimulate inflammation with the potential to generate antitumor immunity. Herein we describe Parapoxvirus ovis (Orf virus (OrfV)), an oncolytic poxvirus, as a viral immunotherapy for ovarian cancer. Methods The immunotherapeutic potential of OrfV was tested in the ID8 orthotopic mouse model of end-stage epithelial ovarian carcinoma. Immune cell profiling, impact on secondary lesion development and survival were evaluated in OrfV-treated mice as well as in Batf3 knockout, mice depleted of specific immune cell subsets and in mice where the primary tumor was removed. Finally, we interrogated gene expression datasets from primary human ovarian tumors from the International Cancer Genome Consortium database to determine whether the interplay we observed between natural killer (NK) cells, classical type 1 dendritic cells (cDC1s) and T cells exists and influences outcomes in human ovarian cancer. Results OrfV was an effective monotherapy in a murine model of advanced-stage epithelial ovarian cancer. OrfV intervention relied on NK cells, which when depleted abrogated antitumor CD8 + T-cell responses. OrfV therapy was shown to require cDC1s in experiments with BATF3 knockout mice, which do not have mature cDC1s. Furthermore, cDC1s governed antitumor NK and T-cell responses to mediate antitumor efficacy following OrfV. Primary tumor removal, a common treatment option in human patients, was effectively combined with OrfV for optimal therapeutic outcome. Analysis of human RNA sequencing datasets revealed that cDC1s correlate with NK cells in human ovarian cancer and that intratumoral NK cells correlate positively with survival. Conclusions The data herein support the translational potential of OrfV as an NK stimulating immunotherapeutic for the treatment of advanced-stage ovarian cancer.
Racial and Ethnic Representation of Participants in US Clinical Trials of New Drugs and Biologics—Reply
Authors: Milena Lolic, Richardae Araojo, Janet Woodcock
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MACHINE LEARNING FOR PREDICTION OF ALL-CAUSE MORTALITY AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Jacek Kwiecinski, Maciej Dabrowski, Kajetan Grodecki, Anna Pylko, Lukasz Kalinczuk, Bartosz Rymuza, janusz Kochman, Zbigniew Chmielak, Zenon Huczek, Piotr Slomka, Adam Witkowski
Journal: Journal of the American College of Cardiology (2022)
Role of adherent and invasive<i>Escherichia coli</i>in Crohn’s disease: lessons from the postoperative recurrence model
Authors: Anthony Buisson, Harry Sokol, Nassim Hammoudi, Stéphane nancey, Xavier Treton, Maria Nachury, Mathurin Fumery, Xavier Hébuterne, Michael Rodrigues, Jean-Pierre Hugot, Gilles Boschetti, Carmen Stefanescu, Pauline Wils, Philippe Seksik, Lionel Le Bourhis, Madeleine Bezault, Pierre Sauvanet, Bruno Pereira, Matthieu Allez, Nicolas Barnich
Journal: Gut (2022)

Objective We used the postoperative recurrence model to better understand the role of adherent and invasive Escherichia coli (AIEC) bacteria in Crohn’s disease (CD), taking advantage of a well-characterised postoperative cohort. Design From a prospective, multicentre cohort of operated patients with CD, AIEC identification was performed within the surgical specimen (M0) (N=181 patients) and the neoterminal ileum (n=119 patients/181) during colonoscopy performed 6 months after surgery (M6). Endoscopic postoperative recurrence was graded using Rutgeerts’ index. The mucosa-associated microbiota was analysed by 16S sequencing at M0 and M6. Relative risks or ORs were adjusted on potential confounders. Results AIEC prevalence was twofold higher within the neoterminal ileum at M6 (30.3%) than within the surgical specimen (14.9%) (p&lt;0.001). AIEC within the neoterminal ileum at M6 was associated with higher rate of early ileal lesions (i1) (41.6% vs 17.1%; aRR 3.49 (95% CI 1.01 to 12.04), p=0.048) or ileal lesions (i2b+i3) (38.2% vs 17.1%; aRR 3.45 (95% CI 1.06 to 11.30), p=0.040) compared with no lesion (i0). AIEC within the surgical specimen was predictive of higher risk of i2b-endoscopic postoperative recurrence (POR) (aOR 2.54 (95% CI 1.01 to 6.44), p=0.049) and severe endoscopic POR (aOR 3.36 (95% CI 1.25 to 9.06), p=0.017). While only 5.0% (6/119) of the patients were AIEC-positive at both M0 and M6, 43.7% (52/119), patients with history of positive test for AIEC (M0 or M6) had higher risk of ileal endoscopic POR (aOR 2.32 (95% CI 1.01 to 5.39), p=0.048)), i2b-endoscopic postoperative recurrence (aOR 2.41 (95% CI 1.01 to 5.74); p=0.048) and severe endoscopic postoperative (aOR=3.84 (95% CI 1.32 to 11.18), p=0.013). AIEC colonisation was associated with a specific microbiota signature including increased abundance of Ruminococcus gnavus . Conclusion Based on the postoperative recurrence model, our data support the idea that AIEC are involved in the early steps of ileal CD. Trial registration number NCT03458195 .
RACIAL INEQUALITIES IN THE USE OF TRANSCATHETER AORTIC VALVE REPLACEMENT AMONG US ADULTS WITH AORTIC STENOSIS: A BLINDER-OAXACA DECOMPOSITION ANALYSIS
Authors: Olamide Oyenubi, Patrick A. Benjamin, Marvyn Allen G. Chan, Bisrat Teweldemedhin, Bernard Gitler, Stephen Jesmajian
Journal: Journal of the American College of Cardiology (2022)
AORTIC ARCH TYPE IN PATIENTS BEING EVALUATED FOR TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Najam Wasty, Muhammad Khakwani, Rajiv Tayal, Mohsin Mughal, Mohammad Thawabi, Tej Phatak, S M Nazmus Sakib, Arash Salemi, Mihir Barvalia
Journal: Journal of the American College of Cardiology (2022)
UNCERTAINITIES IN THE MANAGEMENT OF ST-ELEVATION MYOCARDIAL INFARCTION WITH INFECTIVE ENDOCARDITIS: A SYSTEMATIC REVIEW
Authors: Ramy Abdelmaseih, Ravi A. Thakker, Mustajab Hasan, Mohammed Faluk, Ali Mohsin Choudhry, Jigar H. Patel, Wissam Khalife
Journal: Journal of the American College of Cardiology (2022)
Deep Inspiration Breath Hold and Global Longitudinal Strain in Women Undergoing Left-Sided Breast Irradiation
Authors: Arnold C.T. Ng, Xin Dong, Harish Sharma, Anne Barnard, Elizabeth Brown, Nakia-Rae Beaton, Patricia Browne, Catherine Hargrave, Sharon Watson, Jennifer Harvey, Tao Mai, Margot Lehman
Journal: JACC CardioOncology (2022)
Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells
Authors: Weiqi Hong, Jingyun Yang, Jun Zou, Zhenfei Bi, Cai He, Hong Lei, Xuemei He, Xue Li, Aqu Alu, Wenyan Ren, Zeng Wang, Xiaohua Jiang, Kunhong Zhong, Guowen Jia, Yun Yang, Wenhai Yu, Qing Huang, Mengli Yang, Yanan Zhou, Yuan Zhao, Dexuan Kuang, Junbin Wang, Haixuan Wang, Siyuan Chen, Min Luo, Ziqi Zhang, Tianqi Lu, Li Chen, Haiying Que, Zhiyao He, Qiu Sun, Wei Wang, Guobo Shen, Guangwen Lu, Zhiwei Zhao, Li Yang, Jinliang Yang, Zhenling Wang, Jiong Li, Xiangrong Song, Lunzhi Dai, Chong Chen, Jia Geng, Maling Gou, Lu Chen, Haohao Dong, Yong Peng, Canhua Huang, Zhiyong Qian, Wei Cheng, Changfa Fan, Yuquan Wei, Zhaoming Su, Aiping Tong, Shuaiyao Lu, Xiaozhong Peng, Xiawei Wei
Journal: Cellular and Molecular Immunology (2022)

Abstract Neutrophil extracellular traps (NETs) can capture and kill viruses, such as influenza viruses, human immunodeficiency virus (HIV), and respiratory syncytial virus (RSV), thus contributing to host defense. Contrary to our expectation, we show here that the histones released by NETosis enhance the infectivity of SARS-CoV-2, as found by using live SARS-CoV-2 and two pseudovirus systems as well as a mouse model. The histone H3 or H4 selectively binds to subunit 2 of the spike (S) protein, as shown by a biochemical binding assay, surface plasmon resonance and binding energy calculation as well as the construction of a mutant S protein by replacing four acidic amino acids. Sialic acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S protein. Moreover, histones enhance cell–cell fusion. Finally, treatment with an inhibitor of NETosis, histone H3 or H4, or sialic acid notably affected the levels of sgRNA copies and the number of apoptotic cells in a mouse model. These findings suggest that SARS-CoV-2 could hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for COVID-19.
DEVICE IMPLANTATION CHALLENGES IN A PATIENT WITH PNEUMONECTOMY INDUCED SINUS NODE DYSFUNCTION AND IATROGENIC DEXTROCARDIA
Authors: Edmond Obeng-Gyimah, Ghaith Sharaf Dabbagh, C. Anwar A. Chahal, Mahdi Veillet-Chowdhury, Matthew J. Singleton, Jefferson Lee, Brian T. Schuler, Gregory Fazio
Journal: Journal of the American College of Cardiology (2022)
THE RELATION OF TESTOSTERONE LEVEL TO CARDIAC HYPERTROPHY IN FEMALE HYPERTROPHIC CARDIOMYOPATHY PATIENTS UNDERGOING SEPTAL MYECTOMY
Authors: Jian Zhang, Changpeng Song, Changsheng Zhu, Changrong Nie, Yang Zhang, Manyun Huang, Xinxin Zheng, Jie Lu, Shuiyun Wang, Xiaohong Huang
Journal: Journal of the American College of Cardiology (2022)
Abstract P1-06-09: The role of miR-155-5p in MSI2 induced metastasis of prolonged DEHP exposed triple-negative breast cancer cells
Authors: Mahendra Gunvantrao Jadhao, Chien Chih Chiu
Journal: Cancer Research (2022)

Abstract Phthalate leaching, environmental pollution,and human exposure is major issue. Endocrine disrupting effects of phthalate exposure on human health are well documented affecting hormonal balance, reproductive system, endometriosis, and is a suspected carcinogen. Continuous and prolonged use of plastic products leads to direct human exposure to phthalates, a problem observed in developing countries. In an attempt to mimic continuous human exposure to phthalates, we investigated the effects of long term DEHP exposure at physiological concentration on breast cancer cells. Long-term DEHP exposure enhanced migration and invasion in triple negative breast cancer cells in vitro and in vivo zebrafish xenograft assay indicating ER independent activity of DEHP. NGS identified oncogenic protein, Musashi RNA binding protein2 (MSI2) as metastasis regulator in DEHP exposed breast cancer cells. Elevated MSI2 expression induced metastatic potential through MSI2/Vimentin interaction, EMT and PI3K/Akt/NFκB/MMP9 axis activation. Besides metastatic properties MSI2 overexpression increased stem cell potential in triple negative breast cancer cells. Novel MSI2-Vimentin protein-protein interaction was evidenced in DEHP exposed breast cancer cells highlighting new function of MSI2 apart from RNA-binding and translation regulation. Reduced expression of miR-155-5p was found to negatively regulate MSI2 expression in DEHP exposed breast cancercells. miR-155-5p mimic treatment reduced expression of MSI2 and MSI2 mediated metastasis. MSI2 knockdown reversed EMT and PI3K/Akt/NFκB/MMP9 axis induced metastasis in vitro and in vivo zebrafish xenograft in DEHP exposed breast cancer cells, showing no effect non DEHP exposed breast cancer cells. Organ specific metastasis activity was observed in invivo mouse breast cancer metastasis model showing lung metastasis in DEHP exposed breast cancer cell implanted mice. MSI2 depletion reduced lung metastasis in vivo, however no effectof MSI2 depletion observed on proliferation and tumor size. MSI2 targeting might serve as a promising strategy to overcome highly metastatic breast cancer and to limit stem cell like cancer progression. Keywords: Breast cancer;DEHP; long phthalate exposure; ATP-binding transporter proteins; drug resistance; tariquidar; NGS; MSI2; metastasis; EMT; Vimentin; miR-155-5p;stemness Citation Format: Mahendra Gunvantrao Jadhao, Chien Chih Chiu. The role of miR-155-5p in MSI2 induced metastasis of prolonged DEHP exposed triple-negative breast cancer cells [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P1-06-09.
The principles of whole-hospital predictive analytics monitoring for clinical medicine originated in the neonatal ICU
Authors: J. Randall Moorman
Journal: npj Digital Medicine (2022)

In 2011, a multicenter group spearheaded at the University of Virginia demonstrated reduced mortality from real-time continuous cardiorespiratory monitoring in the neonatal ICU using what we now call Artificial Intelligence, Big Data, and Machine Learning. The large, randomized heart rate characteristics trial made real, for the first time that we know of, the promise that early detection of illness would allow earlier and more effective intervention and improved patient outcomes. Currently, though, we hear as much of failures as we do of successes in the rapidly growing field of predictive analytics monitoring that has followed. This Perspective aims to describe the principles of how we developed heart rate characteristics monitoring for neonatal sepsis and then applied them throughout adult ICU and hospital medicine. It primarily reflects the work since the 1990s of the University of Virginia group: the theme is that sudden and catastrophic deteriorations can be preceded by subclinical but measurable physiological changes apparent in the continuous cardiorespiratory monitoring and electronic health record.
WOMEN-SPECIFIC RISK FACTORS FOR VENTRICULAR TACHYARRHYTHMIA AMONG PRIMARY PREVENTION IMPLANTABLE CARDIOVERTER DEFIBRILLATOR PATIENTS
Authors: Amole Ojo, Arwa Younis, Shireen Saxena, Valentina Kutyifa, Anita Yin Ling Chen, Scott McNitt, Bronislava Polonsky, Mehmet K. Aktas, David T. Huang, Spencer Z. Rosero, Wojciech Zareba, Ilan Goldenberg
Journal: Journal of the American College of Cardiology (2022)
SHOULD HOMOZYGOUS V142I TRANSTHYRETIN AMYLOIDOSIS PATIENTS BE CONSIDERED FOR SCREENING FOR SARCOIDOSIS?
Authors: Manavotam Singh, Johana Fajardo, Monisha S. Kisling, Sara Ahmed, Tania A. Vora, Nana Afari-Armah, Mark Hofmeyer, Ajay Kadakkal, Farooq H. Sheikh
Journal: Journal of the American College of Cardiology (2022)
Food bank use is a canary in the coal mine for mental health services
Authors: Tom Pollard
Journal: BMJ (2022)

Food bank use is a canary in the coal mine for mental health services Tom Pollard mental health social workerThe NHS Confederation recently warned of a "second pandemic" of mental health problems in the wake of covid-19. 1Alongside the direct psychological impact of the last two years and the capacity of overstretched NHS services to respond, economic circumstances in the aftermath of the pandemic will play a key role in shaping the mental health fallout.Competing interests: none declared 1 NHS Confederation.(2022) Mental healthcare recovery plan urgently needed to tackle 'second pandemic' https://www.nhsconfed.org/news/mental-healthcare-recovery-plan-urgently-needed-tackle-second-pandemic 2 Data sourced from DWP's 'Stat-Xplore' tool.3
EFFICACY AND SAFETY OF DUAL ANTIPLATELET THERAPY VERSUS DIRECT ORAL ANTICOAGULANT FOLLOWING LEFT ATRIAL APPENDAGE CLOSURE - A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Neha Patel, Mitra Patel, Cameron Burmeister, Sapan Bhuta, Ahmed Elzanaty, Ehab Ahmed Eltahawy
Journal: Journal of the American College of Cardiology (2022)
Prevalence and characteristics of progressive fibrosing interstitial lung disease in a prospective registry
Authors: Nathan Hambly, M. Malik Farooqi, Anna Dvorkin-Gheva, Kathryn Donohoe, Kristopher Garlick, Ciaran Scallan, Sy Giin Chong, Sarah MacIsaac, Deborah Assayag, Kerri A. Johannson, Charlene D. Fell, Veronica Marcoux, Helene Manganas, Julie Morisset, Alessia Comes, Jolene H. Fisher, Shane Shapera, Andrea S. Gershon, Teresa To, Alyson W. Wong, Mohsen Sadatsafavi, Pierce G. Wilcox, Andrew J. Halayko, Nasreen Khalil, Gerard Cox, Luca Richeldi, Christopher J. Ryerson, Martin Kolb
Journal: European Respiratory Journal (2022)

Progressive fibrosing interstitial lung disease (PF-ILD) is characterised by progressive physiological, symptomatic and/or radiographic worsening. The real-world prevalence and characteristics of PF-ILD remain uncertain.Patients were enrolled from the Canadian Registry for Pulmonary Fibrosis between 2015 and 2020. PF-ILD was defined as a relative forced vital capacity (FVC) decline ≥10%, death, lung transplantation or any two of: relative FVC decline ≥5% and <10%, worsening respiratory symptoms or worsening fibrosis on computed tomography of the chest, all within 24 months of diagnosis. Time-to-event analysis compared progression between key diagnostic subgroups. Characteristics associated with progression were determined by multivariable regression.Of 2746 patients with fibrotic ILD (mean±sd age 65±12 years; 51% female), 1376 (50%) met PF-ILD criteria in the first 24 months of follow-up. PF-ILD occurred in 427 (59%) patients with idiopathic pulmonary fibrosis (IPF), 125 (58%) with fibrotic hypersensitivity pneumonitis (HP), 281 (51%) with unclassifiable ILD (U-ILD) and 402 (45%) with connective tissue disease-associated ILD (CTD-ILD). Compared with IPF, time to progression was similar in patients with HP (hazard ratio (HR) 0.96, 95% CI 0.79-1.17), but was delayed in patients with U-ILD (HR 0.82, 95% CI 0.71-0.96) and CTD-ILD (HR 0.65, 95% CI 0.56-0.74). Background treatment varied across diagnostic subtypes, with 66% of IPF patients receiving antifibrotic therapy, while immunomodulatory therapy was utilised in 49%, 61% and 37% of patients with CHP, CTD-ILD and U-ILD, respectively. Increasing age, male sex, gastro-oesophageal reflux disease and lower baseline pulmonary function were independently associated with progression.Progression is common in patients with fibrotic ILD, and is similarly prevalent in HP and IPF. Routinely collected variables help identify patients at risk for progression and may guide therapeutic strategies.