tbuckley/cabot-search huggingface dataset:
Role for Telomerase in Pulmonary Hypertension
Authors: Nathalie Mouraret, Amal Houssaïni, Shariq Abid, Rozenn Quarck, Elisabeth Marcos, Aurelien Parpaleix, Guillaume Gary-Bobo, Jean-Luc Dubois-Randé, Geneviève Derumeaux, Jorge Boczkowski, Marion Delcroix, Maria A. Blasco, Larissa Lipskaia, Valérie Amsellem, Serge Adnot
Journal: Circulation (2014)

Cells exhibiting dysregulated growth may express telomerase reverse transcriptase (TERT), the dual function of which consists of maintaining telomere length, in association with the RNA template molecule TERC, and controlling cell growth. Here, we investigated lung TERT in human and experimental pulmonary hypertension (PH) and its role in controlling pulmonary artery smooth muscle cell (PA-SMC) proliferation.Marked TERT expression or activity was found in lungs from patients with idiopathic PH and from mice with PH induced by hypoxia or serotonin-transporter overexpression (SM22-5HTT(+) mice), chiefly within PA-SMCs. In cultured mouse PA-SMCs, TERT was expressed on growth stimulation by serum. The TERT inhibitor imetelstat and the TERT activator TA65 abrogated and stimulated PA-SMC growth, respectively. PA-SMCs from PH mice showed a heightened proliferative phenotype associated with increased TERT expression, which was suppressed by imetelstat treatment. TERC(-/-) mice at generation 2 and TERT(-/-) mice at generations 2, 3, and 4 developed less severe PH than did wild-type mice exposed to chronic hypoxia, with less distal pulmonary artery muscularization and fewer Ki67-stained proliferating PA-SMCs. Telomere length differed between TERC(-/-) and TERT(-/-) mice, whereas PH severity was similar in the 2 strains and across generations. Chronic imetelstat treatment reduced hypoxia-induced PH in wild-type mice or partially reversed established PH in SM22-5HTT(+) mice while simultaneously decreasing TERT expression. Opposite effects occurred in mice treated with TA65.Telomerase exerts telomere-independent effects on PA-SMC growth in PH and may constitute a treatment target for PH.
Malpractice claims. Does the past predict the future?
Authors: L. E. Smarr
Journal: JAMA (1994)

THE HEALTH Care Quality Improvement Act of 1986 established the National Practitioner Data Bank (NPDB) as a supplemental means for health care authorities and credentialing organizations to identify practitioners who may have left a bad track record when moving from one locale to another. In 1992, the Data Bank commissioned several independent reviews of already-existing databases to investigate the value of having small-claim payments reported to the Data Bank. See also p 1421. The study by Bovbjerg and Petronis<sup>1</sup>published in this issue ofThe Journalprovides useful insight regarding claims reported during the period 1975 through 1983 against 8247 Florida physicians. The objective of the study was to investigate whether an association exists between past and subsequent claims of medical malpractice. While the study reviews all actual claims indexed, those resulting in payment are of greatest value with respect to the NPDB, as only claim payments are reported
2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Eosinophilic Granulomatosis with Polyangiitis
Authors: Peter C Grayson, Cristina Ponte, Ravi Suppiah, Joanna C Robson, Anthea Craven, Andrew Judge, Sara Khalid, Andrew Hutchings, Raashid A Luqmani, Richard A Watts, Peter A Merkel
Journal: Annals of the Rheumatic Diseases (2022)

To develop and validate revised classification criteria for eosinophilic granulomatosis with polyangiitis (EGPA).Patients with vasculitis or comparator diseases were recruited into an international cohort. The study proceeded in five phases: (1) identification of candidate criteria items using consensus methodology, (2) prospective collection of candidate items present at the time of diagnosis, (3) data-driven reduction of the number of candidate items, (4) expert panel review of cases to define the reference diagnosis and (5) derivation of a points-based risk score for disease classification in a development set using least absolute shrinkage and selection operator logistic regression, with subsequent validation of performance characteristics in an independent set of cases and comparators.The development set for EGPA consisted of 107 cases of EGPA and 450 comparators. The validation set consisted of an additional 119 cases of EGPA and 437 comparators. From 91 candidate items, regression analysis identified 11 items for EPGA, 7 of which were retained. The final criteria and their weights were as follows: maximum eosinophil count ≥1×109/L (+5), obstructive airway disease (+3), nasal polyps (+3), cytoplasmic antineutrophil cytoplasmic antibody (ANCA) or anti-proteinase 3-ANCA positivity (-3), extravascular eosinophilic predominant inflammation (+2), mononeuritis multiplex/motor neuropathy not due to radiculopathy (+1) and haematuria (-1). After excluding mimics of vasculitis, a patient with a diagnosis of small- or medium-vessel vasculitis could be classified as having EGPA if the cumulative score was ≥6 points. When these criteria were tested in the validation data set, the sensitivity was 85% (95% CI 77% to 91%) and the specificity was 99% (95% CI 98% to 100%).The 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Eosinophilic Granulomatosis with Polyangiitis demonstrate strong performance characteristics and are validated for use in research.
Complications in bone‐grafting procedures: Classification and management
Authors: Ignacio Sanz‐Sánchez, Ignacio Sanz‐Martín, Alberto Ortiz‐Vigón, Ana Molina, Mariano Sanz
Journal: Periodontology 2000 (2022)

Abstract Bone‐regenerative interventions aiming to restore deficient alveolar ridges, such as the use of block grafts or through the application of guided bone‐regeneration principles, have reported positive outcomes in the published scientific literature. These interventions, however, are invasive, and hence, intraoperative and/or postoperative complications may occur. The types of complications and their severity may vary from the exposure of the biomaterial (membrane or graft) to postsurgical infections, neurosensorial disturbances, occurrence of hemorrhage, and pain, etc. The aim of the present narrative review was to search the available scientific evidence concerning the incidence of these complications, their effect on treatment outcomes, their clinical management and, finally, strategies aimed at prevention. Exposure of the barrier membrane or the block graft is the most common complication associated with oral regenerative interventions. To manage these complications, depending on the extent of the exposure and the presence or absence of concomitant infections, therapeutic measures may vary, from the topical application of antiseptics to the removal of the barrier membrane or the block graft. Regardless of their treatment, the occurrence of these complications has been associated with patient selection, with compliant patients (eg, nonsmokers) having a lower reported incidence of complications. Similarly, surgical factors such as correct flap elevation and a tensionless closure are of obvious importance. Finally, to prevent the incidence of complications, it appears prudent to utilize whenever possible less invasive surgical interventions.
CCL17 Aggravates Myocardial Injury by Suppressing Recruitment of Regulatory T Cells
Authors: Guoshuai Feng, Geetika Bajpai, Pan Ma, Andrew Koenig, Andrea Bredemeyer, Inessa Lokshina, Lulu Lai, Irmgard Förster, Florian Leuschner, Daniel Kreisel, Kory J. Lavine
Journal: Circulation (2022)

Recent studies have established that CCR2 (C-C chemokine receptor type 2) marks proinflammatory subsets of monocytes, macrophages, and dendritic cells that contribute to adverse left ventricle (LV) remodeling and heart failure progression. Elucidation of the effector mechanisms that mediate adverse effects of CCR2
Ketamine for the acute treatment of severe suicidal ideation: double blind, randomised placebo controlled trial
Authors: Mocrane Abbar, Christophe Demattei, Wissam El-Hage, Pierre-Michel Llorca, Ludovic Samalin, Pierre Demaricourt, Raphael Gaillard, Philippe Courtet, Guillaume Vaiva, Philip Gorwood, Pascale Fabbro, Fabrice Jollant
Journal: BMJ (2022)

To confirm the rapid onset anti-suicidal benefits of ketamine in the short term and at six weeks, overall and according to diagnostic group.Prospective, double blind, superiority, randomised placebo controlled trial.Seven French teaching hospitals between 13 April 2015 and 12 March 2019.Aged 18 or older with current suicidal ideation, admitted to hospital voluntarily. Exclusion criteria included a history of schizophrenia or other psychotic disorders, substance dependence, and contraindications for ketamine.156 participants were recruited and randomised to placebo (n=83) or ketamine (n=73), stratified by centre and diagnosis: bipolar, depressive, or other disorders.Two 40 minute intravenous infusions of ketamine (0.5 mg/kg) or placebo (saline) were administered at baseline and 24 hours, in addition to usual treatment.The primary outcome was the rate of patients in full suicidal remission at day 3, according to the scale for suicidal ideation total score ≤3. Analyses were conducted on an intention-to-treat basis.More participants receiving ketamine reached full remission of suicidal ideas at day 3 than those receiving placebo: 46 (63.0%) of 83 participants in the ketamine arm and 25 (31.6%) of 73 in the placebo arm (odds ratio 3.7 (95% confidence interval 1.9 to 7.3), P<0.001). This effect differed according to the diagnosis (treatment: P<0.001; interaction: P=0.02): bipolar (odds ratio 14.1 (95% confidence interval 3.0 to 92.2), P<0.001), depressive (1.3 (0.3 to 5.2), P=0.6), or other disorders (3.7 (0.9 to 17.3, P=0.07)). Side effects were limited. No manic or psychotic symptom was seen. Moreover, a mediating effect of mental pain was found. At week 6, remission in the ketamine arm remained high, although non-significantly versus placebo (69.5% v 56.3%; odds ratio 0.8 (95% confidence interval 0.3 to 2.5), P=0.7).The findings indicate that ketamine is rapid, safe in the short term, and has persistent benefits for acute care in suicidal patients. Comorbid mental disorders appear to be important moderators. An analgesic effect on mental pain might explain the anti-suicidal effects of ketamine.ClinicalTrials.gov NCT02299440.
Private uncertainty.
Journal: BMJ (1979)

scrape and culture have failed metronidazole, 400 mg twice daily for two to three days, should be tried.Men treated for gonorrhoea should be carefully observed for two to three weeks afterwards in case non-gonococcal urethritis develops.Should it do so appropriate treatment should be given to both patient and consort.A drug that could be given in one or two doses, effective against both gonorrhoea and non-gonococcal urethritis, would be invaluable -provided that it was reasonably cheap.The precise extent of the risk of pelvic inflammatory disease for female contacts is not yet clear, but C trachomatis was thought responsible for two-thirds of a series of 143 laparoscopically confirmed cases of pelvic inflammatory disease in Sweden.8A more obvious risk is that these women may infect other sexual partners, or their babies.If all female contacts could be given appropriate treatment, the reservoir of infection would be much reduced.
Macrophage-targeting gene silencing orchestrates myocardial microenvironment remodeling toward the anti-inflammatory treatment of ischemia-reperfusion (IR) injury
Authors: Yao Wang, Mengying Hou, Shanzhou Duan, Ziyin Zhao, Xuejie Wu, Yongbing Chen, Lichen Yin
Journal: Bioactive Materials (2022)

Ischemia-reperfusion (IR) injury represents a major cause of myocardial dysfunction after infarction and thrombolytic therapy, and it is closely related to the free radical explosion and overwhelming inflammatory responses. Herein, macrophage-targeting nanocomplexes (NCs) are developed to mediate efficient co-delivery of siRNA against MOF (siMOF) and microRNA-21 (miR21) into myocardial macrophages, cooperatively orchestrating the myocardial microenvironment against IR injury. Bioreducible, branched poly(β-amino ester) (BPAE-SS) is designed to co-condense siMOF and miR21 into NCs in a multivalency-reinforced approach, and they are surface-decorated with carboxylated mannan (Man-COOH) to shield the positive surface charges and enhance the serum stability. The final MBSsm NCs are efficiently internalized by myocardial macrophages after systemic administration, wherein BPAE-SS is degraded into small segments by intracellular glutathione to promote the siMOF/miR21 release, finally provoking efficient gene silencing. Thus, cardiomyocyte protection and macrophage modulation are realized via the combined effects of ROS scavenging, inflammation inhibition, and autophagy attenuation, which ameliorates the myocardial microenvironment and restores the cardiac function via positive cellular crosstalk. This study renders promising solutions to address the multiple systemic barriers against in vivo nucleic acid delivery, and it also offers new options for IR injury by manipulating multiple reciprocal bio-reactions.
Cancer Biosimilars—A Regulatory Success So Far, but Value Still to Be Determined
Authors: Douglas W. Blayney, Samuel M. Silver
Journal: JAMA Oncology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Induction of Allergen-Neutralizing IgG4 and IgA Blocking Antibodies Following Subcutaneous Immunotherapy with Mannan-Conjugated Birch Pollen Allergoid
Authors: Alistair Devine, Esther Raskopf, Rebecca Parkin, Elizabeth Palmer, Lea Radtke, Miguel Casanovas, Mandy Cuevas, Ralph Mösges, Mohamed Shamji
Journal: Journal of Allergy and Clinical Immunology (2022)
Leadless Pacing—Uncertainties Remain About Safety and Efficacy—Reply
Authors: Mikhael F. El-Chami, Jonathan P. Piccini, Lindsay Bockstedt
Journal: JAMA Cardiology (2022)

In Reply We thank Ngo et al for their interest in our article.1 Our study reported the rate of acute complications, device complications at 6 months, and need for system revision at 6 months among patients implanted with a leadless VVI vs transvenous VVI pacemaker using Medicare claims data.
CLASSIFICATION OF MORBID PROCESSES.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myasthenia Gravis
Authors: Marjorie E. Seybold
Journal: JAMA (1983)

MYASTHENIA gravis (MG) is an autoimmune disorder caused by antibodies directed against the acetylcholine receptor (AChR) of skeletal muscle. Although the prevalence of MG is only about one per 20,000 people in the United States, it is the best studied and best understood of the neuroreceptor disorders. As such, it is likely to serve as the prototype for the understanding of more common organ-specific autoimmune disorders. <h3>Clinical Characteristics</h3> Myasthenia gravis has no racial or geographic predilection. Although it is extremely rare during the first two years of life, MG may occur at almost any age. Females are affected more commonly than males (about 2:1), and this female preponderance is most striking during young adulthood. The disease shows decreasing sexual preference with increasing age and may even show a slight male preponderance in the elderly. Familial cases are uncommon, and no consistent HLA type or genetic inheritance pattern has been identified.
Multiple FLG variants drive eczema severity in the LEAP study participants
Authors: Michelle Huffaker, Kanika Kanchan, Henry Bahnson, Ingo Ruczinski, Gautam Shankar, Donald Leung, Carolyn Baloh, George Du Toit, Gideon Lack, Gerald Nepom, Rasika Mathias
Journal: Journal of Allergy and Clinical Immunology (2022)
TCT CONNECT-298 Real-World Experience of the Manta Closure Device: Insights From the FDA Manufacturer and User Facility Device Experience (MAUDE) Database
Authors: Brian Case, Sant Kumar, Charan Yerasi, Brian Forrestal, Anees Musallam, Chava Chezar-Azerrad, Nauman Khalid, Evan Shlofmitz Dupe, Lowell Satler, Itsik Ben-Dor, Hayder Hashim, Toby Rogers, Ron Waksman
Journal: Journal of the American College of Cardiology (2020)
Risk-Based Screening for Cancer in Patients With Dermatomyositis
Authors: Heidi Vaughan, Hope S. Rugo, Anna Haemel
Journal: JAMA Dermatology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
The future of human behaviour research
Authors: Janet M. Box-Steffensmeier, Jean Burgess, Maurizio Corbetta, Kate Crawford, Esther Duflo, Laurel Fogarty, Alison Gopnik, Sari Hanafi, Mario Herrero, Ying-yi Hong, Yasuko Kameyama, Tatia M. C. Lee, Gabriel M. Leung, Daniel S. Nagin, Anna C. Nobre, Merete Nordentoft, Aysu Okbay, Andrew Perfors, Laura M. Rival, Cassidy R. Sugimoto, Bertil Tungodden, Claudia Wagner
Journal: Nature Human Behaviour (2022)
A program for the care of patients with chronic diseases
Authors: J. W. Runyan
Journal: JAMA (1970)

Neighborhood clinics staffed by public health nurses have provided medical care to patients with certain stabilized chronic diseases (primarily, cardiac disease, hypertension, and diabetes) since 1963. Recently revised medical policies permit the nursing staff to assume even greater responsibility in rendering service which has increased the effectiveness of the program. The current policies permit the nurses to make changes in therapy, as set forth in protocols for each disease category, based upon their own observations and judgment, and, in addition, prescribe symptomatic treatment for minor complaints. Patients are referred to the Medical Center whenever the nurse finds the patient's condition warrants it. This program provides medical care of good quality, conveniently, and at a nominal cost, yet the physicians' time is greatly conserved. Some aspects of the program may have a wide application.
Spouting Chylothorax in Gorham-Stout Disease
Authors: Motoko Nomura, Hiromitsu Ohta, Kentaro Minegishi, Maho Akimoto, Kohei Hamamoto, Yasuhiro Yamaguchi
Journal: American Journal of Respiratory and Critical Care Medicine (2022)

"Spouting Chylothorax in Gorham-Stout Disease." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp. –
Unreviewed Reports
Authors: -Marko Altaras, Gary Goldberg
Journal: BMJ (1985)

Unrezviewed ReportsPain in the ear-a presenting symptom of aortic dissection Two previously well men developed sudden severe pain in the ear.One subsequently had anterior chest pain, the other episodes of confusion, and both died soon after.Ruptured dissecting thoracic aortic aneurysms were found on postmortem examination.The acute onset of pain in the ear as a presenting symptom of aortic dissection is extremely uncommon and recorded in only one of 349 cases.' The neurological basis is probably the auricular branch of the vagus, but it is of no apparent value in localising the dissection.Dissecting thoracic aneurysms should be considered in the differential diagnosis ofacute ear pai.-B I HOFFBRAND, A HOLLMAN, Whittington and University College Hospitals, London.(
SERS Tags for Biomedical Detection and Bioimaging
Authors: Huiqiao Liu, Xia Gao, Chen Xu, Dingbin Liu
Journal: Theranostics (2022)

Surface-enhanced Raman scattering (SERS) has emerged as a valuable technique for molecular identification. Due to the characteristics of high sensitivity, excellent signal specificity, and photobleaching resistance, SERS has been widely used in the fields of environmental monitoring, food safety, and disease diagnosis. By attaching the organic molecules to the surface of plasmonic nanoparticles, the obtained SERS tags show high-performance multiplexing capability for biosensing. The past decade has witnessed the progress of SERS tags for liquid biopsy, bioimaging, and theranostics applications. This review focuses on the advances of SERS tags in biomedical fields. We first introduce the building blocks of SERS tags, followed by the summarization of recent progress in SERS tags employed for detecting biomarkers, such as DNA, miRNA, and protein in biological fluids, as well as imaging from