tbuckley/cabot-search huggingface dataset:
Single-cell multiomics defines tolerogenic extrathymic Aire-expressing populations with unique homology to thymic epithelium
Authors: Jiaxi Wang, Caleb A. Lareau, Jhoanne L. Bautista, Alexander R. Gupta, Katalin Sandor, Joe Germino, Yajie Yin, Matthew P. Arvedson, Gabriella C. Reeder, Nathan T. Cramer, Fang Xie, Vasilis Ntranos, Ansuman T. Satpathy, Mark S. Anderson, James M. Gardner
Journal: Science Immunology (2021)

The autoimmune regulator (Aire), a well-defined transcriptional regulator in the thymus, is also found in extrathymic Aire-expressing cells (eTACs) in the secondary lymphoid organs. eTACs are hematopoietic antigen-presenting cells and inducers of immune tolerance, but their precise identity has remained unclear. Here, we use single-cell multiomics, transgenic murine models, and functional approaches to define eTACs at the transcriptional, genomic, and proteomic level. We find that eTACs consist of two similar cell types: CCR7+ Aire-expressing migratory dendritic cells (AmDCs) and an Airehi population coexpressing Aire and retinoic acid receptor–related orphan receptor γt (RORγt) that we term Janus cells (JCs). Both JCs and AmDCs have the highest transcriptional and genomic homology to CCR7+ migratory dendritic cells. eTACs, particularly JCs, have highly accessible chromatin and broad gene expression, including a range of tissue-specific antigens, as well as remarkable homology to medullary thymic epithelium and RANK-dependent Aire expression. Transgenic self-antigen expression by eTACs is sufficient to induce negative selection and prevent autoimmune diabetes. This transcriptional, genomic, and functional symmetry between eTACs (both JCs and AmDCs) and medullary thymic epithelium—the other principal Aire-expressing population and a key regulator of central tolerance—identifies a core program that may influence self-representation and tolerance across the spectrum of immune development.
Preservation of T-Cell Stemness with a Novel Expansionless CAR-T Manufacturing Process, Which Reduces Manufacturing Time to Less Than Two Days, Drives Enhanced CAR-T Cell Efficacy
Authors: Boris Engels, Xu Zhu, Jennifer Yang, Andrew Price, Akash Sohoni, Andrew M Stein, Lana Parent, Michael Greene, Matthew Niederst, Jeanne Whalen, Elena J Orlando, Louise M Treanor, Jennifer L Brogdon
Journal: Blood (2021)
Subcutaneous (SC) Administration of Mosunetuzumab with Cycle 1 Step-up Dosing Is Tolerable and Active in Patients with Relapsed/Refractory B-Cell Non-Hodgkin Lymphomas (R/R B-NHL): Initial Results from a Phase I/II Study
Authors: Nancy L. Bartlett, Pratyush Giri, L. Elizabeth Budde, Stephen J. Schuster, Sarit Assouline, Matthew J. Matasar, Sung-Soo Yoon, Miguel Canales, Norma C. Gutierrez, Keith Fay, Chan-Yoon Cheah, Paula Marlton, Volker Wiebking, Shen Yin, Iris To, Chi-Chung Li, Huang Huang, Mingzhu Zhou, Elicia Penuel, Carol O'Hear, Laurie H. Sehn
Journal: Blood (2021)
Haploidentical Natural Killer Cell Therapy As an Adjunct to Stem Cell Transplantation for Refractory Acute Myeloid Leukemia
Authors: Uday Prakash Kulkarni, Arun Kumar Arunachalam, Hamenth Kumar Palani, Nithya Balasundaram, Arvind Venkatraman, Anu Korula, Anup J Devasia, Fouzia NA, Sushil Selvarajan, Sharon Lionel, Madhavi Maddali, Aby Abraham, Poonkuzhali Balasubramanian, Biju George, Vikram Mathews
Journal: Blood (2021)
A Bioprinted Tubular Intestine Model Using a Colon‐Specific Extracellular Matrix Bioink
Authors: Hohyeon Han, Yejin Park, Yoo‐mi Choi, Uijung Yong, Byeongmin Kang, Woojung Shin, Soyoun Min, Hyun Jung Kim, Jinah Jang
Journal: Advanced Healthcare Materials (2021)

Tremendous advances have been made toward accurate recapitulation of the human intestinal system in vitro to understand its developmental process, and disease progression. However, current in vitro models are often confined to 2D or 2.5D microarchitectures, which is difficult to mimic the systemic level of complexity of the native tissue. To overcome this problem, physiologically relevant intestinal models are developed with a 3D hollow tubular structure using 3D bioprinting strategy. A tissue-specific biomaterial, colon-derived decellularized extracellular matrix (Colon dECM) is developed and it provides significant maturation-guiding potential to human intestinal cells. To fabricate a perfusable tubular model, a simultaneous printing process of multiple materials through concentrically assembled nozzles is developed and a light-activated Colon dECM bioink is employed by supplementing with ruthenium/sodium persulfate as a photoinitiator. The bioprinted intestinal tissue models show spontaneous 3D morphogenesis of the human intestinal epithelium without any external stimuli. In consequence, the printed cells form multicellular aggregates and cysts and then differentiate into several types of enterocytes, building junctional networks. This system can serve as a platform to evaluate the effects of potential drug-induced toxicity on the human intestinal tissue and create a coculture model with commensal microbes and immune cells for future therapeutics.
Efficacy of Ibrutinib Monotherapy in Pre-Clinical Mouse Models of Richter Transformation: Ibrutinib Effectively Reduces the Incidence of Richter Transformation but Fails in Treating Transformed Lymphoma, Especially in Primary Lymphoid Tissue
Authors: Shih-Shih Chen, Jacqueline Barrientos, Xiao-Jie Yan, Uwe Wirtz, Edith Szafer-Glusman, Kanti R Rai, Nicholas Chiorazzi
Journal: Blood (2021)
Evaluating the Clinical Utility of Staged Bronchoalveolar Lavage (BAL) Fluid Analysis in Adolescent and Adult Acute Leukemia and Lymphoma Patients with Febrile Neutropenia and Lung Infiltrates
Authors: Venkatesh K, Dr. Hasmukh Jain, Jayshree Thorat, Dr. Manju Sengar, Sandeep Tandon, Akshay Baheti, Sweta Bothra, Surabhi Bhat, Dr. Neha Sharma, Sanjay Biswas, Gaurav Salunkhe, George Karimundackal, Avinash Bonda, Lingaraj Nayak, Dr. Bhausaheb Bagal
Journal: Blood (2021)
Sudden loss of vision at the gym
Authors: Jonathan K Y Ng, Kalyan Guduru, James Huxtable
Journal: BMJ (2021)

A woman in her 30s presented to the emergency department with sudden loss of vision in her right eye while doing squats and burpees during a workout at the gym. Initially, the vision in her right eye had become “pixelated,” after which she noticed a “black hole” in the centre of her vision (central scotoma). Her peripheral vision was preserved. She experienced migraines with aura but had no symptoms suggesting migraine during this episode. No other medical or ocular problem was reported and she was not taking regular medication. She quit smoking18 years earlier.

On examination, Snellen visual acuity was counting fingers on the right and 6/5 on the left, unaided. No relative afferent pupillary defect was detected. Both anterior segments were normal. Fundus examination of the right eye showed a boat-shaped pre-retinal haemorrhage overlying the macula (fig 1). No other retinal vascular or fundal abnormalities were detected. The fundus of the left eye …
Moving beyond conventional stratified analysis to assess the treatment effect in a comparative oncology study
Authors: Ryan Sun, Zachary McCaw, Lu Tian, Hajime Uno, Fangxin Hong, Dae Hyun Kim, Lee-Jen Wei
Journal: Journal for ImmunoTherapy of Cancer (2021)

In a comparative oncology study with progression-free or overall survival as the endpoint, the primary or key secondary analysis is routinely stratified by patients’ baseline characteristics when evaluating the treatment difference. The validity of a conventional strategy such as a stratified HR analysis depends on stringent model assumptions that are unlikely to be met in practice, especially in immunotherapy studies. Thus, the resulting summary is generally neither valid nor interpretable. This article discusses issues with conventional stratified analyses and presents alternatives using data from KEYNOTE-189, a recent immunotherapy trial for treating patients with metastatic, non-squamous, non-small-cell lung cancer.
A Novel Asymmetrical Anti-CLL-1×CD3 Bispecific Antibody, ABL602, Induces Potent CLL1-Specific Antitumor Activity with Minimized Sensitization of Pro-Inflammatory Cytokines
Authors: Yangmi Lim, Eunhee Lee, Shinai Lee, Sumyeong Park, Hyeyoung Park, Jonghwa Won
Journal: Blood (2021)
A Large Multicenter Real-World Evidence (RWE) Analysis of Autoimmune (AI) Diseases and Lymphoma: Histologic Associations, Disease Characteristics, Survival, and Prognostication
Authors: Jordan Carter, Adam J. Olszewski, Tatyana A. Feldman, Reem Karmali, Jean L. Koff, Sabarish Ayyappan, Matthew A. Lunning, Shazia Nakohda, Nadia Khan, Aryeh Pelcovits, Jason Lofters, Timothy Seijung Oh, Colin Burke O'Leary, Kittika Poonsombudlert, Carman Tong, Elaine Kuhn, Mingen Liu, Andrea Anampa-Guzman, Megha Shalavadi, Colin Thomas, Melissa Kives, Ning C. Dong, Alexander Hershey, Neil Palmisiano, Alexey V. Danilov, Francisco J. Hernandez-Ilizaliturri, Stefan K. Barta, Frederick Lansigan, Kerry J. Savage, Andrew M. Evens
Journal: Blood (2021)
The Copy Number of Disease-Associated HLA Alleles Predicts the Response to Immunosuppressive Therapy in Acquired Aplastic Anemia
Authors: Yoshitaka Zaimoku, Hiroki Mizumaki, Tatsuya Imi, Kohei Hosokawa, Hiroyuki Maruyama, Takamasa Katagiri, Takeshi Yoroidaka, Noriharu Nakagawa, Mikoto Tanabe, Noriaki Tsuji, Ryota Urushihara, Hiroyuki Takamatsu, Hirohito Yamazaki, Ken Ishiyama, Shinji Nakao
Journal: Blood (2021)
Comparative Outcomes and Molecular Response Predictors of IDH1/2-Mutated Adult Acute Myeloid Leukemia (AML) Patients (Pts) after Frontline Treatment with Intensive Induction Chemotherapy (IC), Targeted Inhibitors, or Hypomethylating Agents (HMA) (Alliance)
Authors: Uma Borate, Prapti A. Patel, Chetasi Talati, Jessica Kohlschmidt, Michael P. Ozga, Yazan F. Madanat, Luke Fletcher, Ravi Patel, Krzysztof Mrózek, Deedra Nicolet, Akriti G Jain, Virginia Olivia Volpe, Fei Yang, Richard D. Press, Daniel Jones, James S. Blachly, Christopher J. Walker, Andrew J Carroll, Guido Marcucci, Maria R. Baer, William Blum, Bayard L. Powell, Jonathan E Kolitz, Richard A. Larson, Richard M. Stone, John C. Byrd, Alice S. Mims, Kendra Sweet, Ann-Kathrin Eisfeld
Journal: Blood (2021)
Connecting copper and cancer: from transition metal signalling to metalloplasia
Authors: Eva J. Ge, Ashley I. Bush, Angela Casini, Paul A. Cobine, Justin R. Cross, Gina M. DeNicola, Q. Ping Dou, Katherine J. Franz, Vishal M. Gohil, Sanjeev Gupta, Stephen G. Kaler, Svetlana Lutsenko, Vivek Mittal, Michael J. Petris, Roman Polishchuk, Martina Ralle, Michael L. Schilsky, Nicholas K. Tonks, Linda T. Vahdat, Linda Van Aelst, Dan Xi, Peng Yuan, Donita C. Brady, Christopher J. Chang
Journal: Nature reviews. Cancer (2021)
Acceleration of chronic wound healing by bio-inorganic polyphosphate: <i>In vitro</i> studies and first clinical applications
Authors: Hadrian Schepler, Meik Neufurth, Shunfeng Wang, Zhengding She, Heinz C. Schröder, Xiaohong Wang, Werner E.G. Müller
Journal: Theranostics (2021)

The healing of chronic wounds is impaired by a lack of metabolic energy.In previous studies, we showed that physiological inorganic polyphosphate (polyP) is a generator of metabolic energy by forming ATP as a result of the enzymatic cleavage of the high-energy phosphoanhydride bonds of this polymer.Therefore, in the present study, we investigated whether the administration of polyP can substitute for the energy deficiency in chronic wound healing.Methods: PolyP was incorporated into collagen mats and applied in vitro and to patients in vivo.Results: (i) In vitro studies: Keratinocytes grown in vitro onto the polyP/collagen mats formed long microvilli to guide them to a favorable environment.HUVEC cells responded to polyP/collagen mats with an increased adhesion and migration propensity as well as penetration into the mats.(ii) In vivohuman clinical studies: In a "bench to bedside" process these promising in vitro results were translated from the laboratory into the clinic.In the proof-of-concept application, the engineered polyP/collagen mats were applied to chronic wounds in patients.Those mats impressively accelerated the re-epithelialization rate, with a reduction of the wound area to 65% after 3 weeks and to 36.6% and 22.5% after 6 and 9 weeks, respectively.Complete healing was achieved and no further treatment was necessary.Biopsy samples from the regenerating wound area showed predominantly myofibroblasts.The wound healing process was supported by the use of a polyP containing moisturizing solution. Conclusion:The results strongly recommend polyP as a beneficial component in mats for a substantial healing of chronic wounds.
Selective IL-1 activity on CD8<sup>+</sup> T cells empowers antitumor immunity and synergizes with neovasculature-targeted TNF for full tumor eradication
Authors: Bram Van Den Eeckhout, Leander Huyghe, Sandra Van Lint, Elianne Burg, Stéphane Plaisance, Frank Peelman, Anje Cauwels, Gilles Uzé, Niko Kley, Sarah Gerlo, Jan Tavernier
Journal: Journal for ImmunoTherapy of Cancer (2021)

Background Clinical success of therapeutic cancer vaccines depends on the ability to mount strong and durable antitumor T cell responses. To achieve this, potent cellular adjuvants are highly needed. Interleukin-1β (IL-1β) acts on CD8 + T cells and promotes their expansion and effector differentiation, but toxicity and undesired tumor-promoting side effects hamper efficient clinical application of this cytokine. Methods This ‘cytokine problem’ can be solved by use of AcTakines ( Ac tivity-on- Ta rget cyto kines ), which represent fusions between low-activity cytokine mutants and cell type-specific single-domain antibodies. AcTakines deliver cytokine activity to a priori selected cell types and as such evade toxicity and unwanted off-target side effects. Here, we employ subcutaneous melanoma and lung carcinoma models to evaluate the antitumor effects of AcTakines. Results In this work, we use an IL-1β-based AcTakine to drive proliferation and effector functionality of antitumor CD8 + T cells without inducing measurable toxicity. AcTakine treatment enhances diversity of the T cell receptor repertoire and empowers adoptive T cell transfer. Combination treatment with a neovasculature-targeted tumor necrosis factor (TNF) AcTakine mediates full tumor eradication and establishes immunological memory that protects against secondary tumor challenge. Interferon-γ was found to empower this AcTakine synergy by sensitizing the tumor microenvironment to TNF. Conclusions Our data illustrate that anticancer cellular immunity can be safely promoted with an IL-1β-based AcTakine, which synergizes with other immunotherapies for efficient tumor destruction.
FGF10 promotes cardiac repair through a dual cellular mechanism increasing cardiomyocyte renewal and inhibiting fibrosis
Authors: Fabien Hubert, Sandy M Payan, Edeline Pelce, Laetitia Bouchard, Rachel Sturny, Nicolas Lenfant, Giovanna Mottola, Frédéric Collart, Robert G Kelly, Francesca Rochais
Journal: Cardiovascular Research (2021)

Promoting cardiomyocyte renewal represents a major therapeutic approach for heart regeneration and repair. Our study aims to investigate the relevance of FGF10 as a potential target for heart regeneration.Our results first reveal that Fgf10 levels are up-regulated in the injured ventricle after MI. Adult mice with reduced Fgf10 expression subjected to MI display impaired cardiomyocyte proliferation and enhanced cardiac fibrosis, leading to a worsened cardiac function and remodelling post-MI. In contrast, conditional Fgf10 overexpression post-MI revealed that, by enhancing cardiomyocyte proliferation and preventing scar-promoting myofibroblast activation, FGF10 preserves cardiac remodelling and function. Moreover, FGF10 activates major regenerative pathways including the regulation of Meis1 expression levels, the Hippo signalling pathway and a pro-glycolytic metabolic switch. Finally, we demonstrate that elevated FGF10 levels in failing human hearts correlate with reduced fibrosis and enhanced cardiomyocyte proliferation.Altogether, our study shows that FGF10 promotes cardiac regeneration and repair through two cellular mechanisms: elevating cardiomyocyte renewal and limiting fibrosis. This study thus identifies FGF10 as a clinically relevant target for heart regeneration and repair in man.
Cytoplasmic Labile Iron Accumulates in Aging Stem Cells Perturbing a Key Rheostat for Identity Control
Authors: Yun-Ruei Kao, Jiahao Chen, Rajni Kumari, Madhuri Tatiparthy, Yuhong Ma, Maria M. Aivalioti, Aliona Zintiridou, Victor Thiruthuvanathan, Julie A. Reisz, Stephanie Stransky, Simone Sidoli, Ulrich G. Steidl, Angelo D'Alessandro, Britta Will
Journal: Blood (2021)
Longitudinal Copy-Number Alteration Analysis in Plasma Cell-Free DNA of Neuroendocrine Neoplasms is a Novel Specific Biomarker for Diagnosis, Prognosis, and Follow-up
Authors: Gitta Boons, Timon Vandamme, Laura Mariën, Willem Lybaert, Geert Roeyen, Tim Rondou, Konstantinos Papadimitriou, Katrien Janssens, Bart Op de Beeck, Marc Simoens, Wim Demey, Isabel Dero, Guy Van Camp, Marc Peeters, Ken Op de Beeck
Journal: Clinical Cancer Research (2021)

As noninvasive biomarkers are an important unmet need for neuroendocrine neoplasms (NEN), biomarker potential of genome-wide molecular profiling of plasma cell-free DNA (cfDNA) was prospectively studied in patients with NEN.Longitudinal plasma samples were collected from patients with well-differentiated, metastatic gastroenteropancreatic and lung NEN. cfDNA was subjected to shallow whole-genome sequencing to detect genome-wide copy-number alterations (CNA) and estimate circulating tumor DNA (ctDNA) fraction, and correlated to clinicopathologic and survival data. To differentiate pancreatic NENs (PNEN) from pancreatic adenocarcinomas (PAAD) using liquid biopsies, a classification model was trained using tissue-based CNAs and validated in cfDNA.One hundred and ninety-five cfDNA samples from 43 patients with NEN were compared with healthy control cfDNA (N = 100). Plasma samples from patients with PNEN (N = 21) were used for comparison with publicly available PNEN tissue (N = 98), PAAD tissue (N = 109), and PAAD cfDNA (N = 96). Thirty percent of the NEN cfDNA samples contained ctDNA and 44% of the patients had at least one ctDNA-positive (ctDNA+) sample. CNAs detected in cfDNA were highly specific for NENs and the classification model could distinguish PAAD and PNEN cfDNA samples with a sensitivity, specificity, and AUC of 62%, 86%, and 79%, respectively. ctDNA-positivity was associated with higher World Health Organization (WHO) grade, primary tumor location, and higher chromogranin A and neuron-specific enolase values. Overall survival was significantly worse for ctDNA+ patients and increased ctDNA fractions were associated with poorer progression-free survival.Sequential genome-wide profiling of plasma cfDNA is a novel, noninvasive biomarker with high specificity for diagnosis, prognosis, and follow-up in metastatic NENs.
Metabolic Profiling Reveals Cellular Reprogramming of Acute Myeloid Leukemia By Omipalisib through Serine Synthesis Pathway
Authors: Liang-In Lin, Tseng Chiyang, Yu-Hsuan Fu, Hsin-An Hou, Wen-Chien Chou, Hwei-Fang Tien
Journal: Blood (2021)
Immunogenetic Drivers in Post-Transplant Acute Myeloid Leukemia Recurrence: Genomic Dysfunction of Human Leukocyte Antigen Diversity
Authors: Simona Pagliuca, Carmelo Gurnari, Laila Terkawi, Ishani Pandit, Tariq Kewan, Waled Bahaj, Minako Mori, Suresh Kumar Balasubramanian, Ashwin Kishtagari, Hetty E. Carraway, Betty K. Hamilton, Navneet S. Majhail, Valeria Visconte, Jaroslaw P. Maciejewski
Journal: Blood (2021)
Abstract PO-012: The concept of artificial intelligence against pancreatic cancer
Authors: Subash Kumar
Journal: Cancer Research (2021)

Abstract Pancreatic cancer (PC) remains the fourth leading cause of cancer-related death in both men and women in the United States. Despite considerable research efforts, pancreatic cancer is associated with a dire prognosis and a 5-year survival rate of only 10%. Early symptoms of the disease are mostly nonspecific. The premise of improved survival through early detection is that more individuals will benefit from potentially curative treatment. Pancreatic ductal adenocarcinoma (PDAC) is on track to become the number 2 cancer killer in the United States within the next decade unless there is a major improvement in outcomes. Surgical resection remains the only reasonable hope for a cure from PDAC. The potential for early detection of asymptomatic pancreatic neoplasms in high-risk individuals using an endoscopic approach, but this approach is operator dependent and at the same time, these existing techniques are favored once patients reach the age of 75 years. Artificial intelligence (AI) methodology has emerged as a successful tool for risk stratification and identification in general health care. Machine learning refers to the study of algorithms that learn their behavior from data. To see why such algorithms are important, consider the following basic task, building a program to predict if an image contains a dog or a cat. Although it is exceedingly difficult for us to manually specify the exact rules to determine that a dog is a dog, it is comparatively straightforward to prepare a reference set of images and labels. This setting, where knowledge is more easily encoded in data rather than as a descriptive set of rules, is the focus of ML algorithms. One of the most promising areas of innovation in medical imaging in the past decade has been the application of deep learning. Deep learning has the potential to impact the entire medical imaging workflow from image acquisition, image registration, to interpretation. Traditional image processing is dominated by algorithms that are based on statistical models. These statistical model-based processing algorithms carry out inference based on a complete knowledge of the underlying statistical model relating the observations at hand and the desired information and do not require data to learn their mapping. In practice, accurate knowledge of the statistical model relating the observations and the desired information is typically unavailable. The past decade has witnessed a deep learning revolution. Deep learning methods have surpassed the state of the art for many problems in signal processing, imaging, and vision with unprecedented performance gains. Citation Format: Subash Kumar. The concept of artificial intelligence against pancreatic cancer [abstract]. In: Proceedings of the AACR Virtual Special Conference on Pancreatic Cancer; 2021 Sep 29-30. Philadelphia (PA): AACR; Cancer Res 2021;81(22 Suppl):Abstract nr PO-012.
mRNA vaccination induces tick resistance and prevents transmission of the Lyme disease agent
Authors: Andaleeb Sajid, Jaqueline Matias, Gunjan Arora, Cheyne Kurokawa, Kathleen DePonte, Xiaotian Tang, Geoffrey Lynn, Ming-Jie Wu, Utpal Pal, Norma Olivares Strank, Norbert Pardi, Sukanya Narasimhan, Drew Weissman, Erol Fikrig
Journal: Science Translational Medicine (2021)

An Ixodes scapularis saliva mRNA vaccine induces tick resistance and prevents Borrelia burgdorferi infection in guinea pigs.
Inhibition of Cyclin Dependent Kinase 8(CDK8): A Novel Approach to Target the Leukemia Initiating Cells (LICs) in T-Cell Acute Lymphoblastic Leukaemia (T-ALL)
Authors: Sujan Piya, Huaxian Ma, Sujan Piya, Vivian Ruvolo, Mahesh Basyal, Aniela Golas, Renata Windak, Tomasz Rzymski, Michael Andreeff, Gautam Borthakur
Journal: Blood (2021)
What Do Patients Think about Palliative Care? a National Survey of Hematopoietic Stem Cell Transplant Recipients
Authors: Areej El-Jawahri, Christa Meyer, Lih-Wen Mau, Deborah Mattila, Linda J Burns, Christina Ullrich, Hemant S. Murthy, William A. Wood, Effie W. Petersdorf, Thomas W. LeBlanc
Journal: Blood (2021)
VO2/DO2 relationship I
Authors: R. Neviere, D. Mathieu, F. Herengt, F. Wattel, P. F. Laterre, A. Dougnac, J. Roeseler, M. Andresen, N. Caruso, M. S. Reynaert, G. Kreymann, S. Grosser, P. Buggisch, C. Gottschall, P. C. Silance, J. L. Vincent, M. N. Smithies, D. J. Bihari, M. C. Becq, J. Mangalaboyi, C. Chopin, M. C. Chambrin, A. Rime, H. Mehdaoui, Ph. Lestavel, F. Fourrier
Journal: Intensive Care Medicine (1992)