tbuckley/cabot-search huggingface dataset:
The natural history of truncus arteriosus.
Authors: CMarcelletti, D CMcGoon, D DMair
Journal: Circulation (1976)

The cases of 23 patients whose condition was diagnosed as truncus arteriosus, type I or II, and who were seen at the Mayo Clinic during the decade preceding 1967, that is, before corrective operation became feasible, were reviewed. Ten were infants (through one year of age), and all ten have died. Eight ranged in age from more than one year through seven years of age, and all are living, except one, who diet 11 years after diagnosis. Five were older than seven years, and all had severe pulmonary vascular obstructive disease; three have died. Thus, 14 of the 23 have died, and all but one surviving patient have mild to moderate disability. The generally grave prognosis for patients with truncus arteriosus warrants continued use of corrective operation, but suggests that the greatest benefit can be realized by successful correction in the infant with congestive heart failure and in early childhood before the development of severe pulmonary vascular obstructive disease.
The role of right and left ventricular function in the ventilatory response to exercise in chronic heart failure.
Authors: A LClark, J WSwan, RLaney, MConnelly, JSomerville, A JCoats
Journal: Circulation (1994)

BACKGROUNDRight ventricular function may be an important determinant of exercise capacity, peak oxygen consumption (VO2), and the ventilatory response to carbon dioxide production (VE/VCO2 relation) in patients with chronic heart failure (CHF).METHODS AND RESULTSWe studied the role of right ventricular function in CHF and also investigated the effects of absent right ventricular reserve in patients previously operated on with Fontan's procedure by measuring metabolic gas exchange during exercise in five groups of patients: (1) 10 patients who had previously undergone Fontan's procedure for congenital heart disease in whom the right ventricle is not functional; (2) 11 age-matched control subjects with dilated cardiomyopathy (DCM); (3) 15 age-matched normal subjects; (4) 42 patients with CHF; and (5) 16 age-matched control subjects. Left and right ventricular ejection fractions (LVEF and RVEF) were measured by radionuclide ventriculography in group 4. In the young subjects, the VE/VCO2 slope was lower in th...
Localization of angiotensinogen messenger RNA in rat aorta.
Authors: L ACassis, K RLynch, M JPeach
Journal: Circulation Research (1988)

The distribution of angiotensinogen messenger (mRNA) was determined in the rat aorta. Other investigators have demonstrated the presence of angiotensinogen mRNA in whole rat aorta; however, its precise location in the blood vessel wall has not been defined. When various layers of the vessel wall were separated by dissection or cell dispersion, angiotensinogen mRNA levels were greatest in the periaortic adipose tissue. Angiotensinogen mRNA was present in very small levels in the adventitia, with no detectable levels in the muscle layer. In addition to periaortic adipose tissue, angiotensinogen mRNA was also present in the interscapular brown fat pad of the rat. The high levels of angiotensinogen mRNA in periaortic brown adipose tissue suggests that angiotensin may be synthesized there and responses may exist in this tissue or adjacent sympathetic nerve terminals.
Unmasking of ventricular preexcitation by vagal stimulation or isoproterenol administration.
Authors: JPrzybylski, P AChiale, M SHalpern, G JNau, M VElizari, M BRosenbaum
Journal: Circulation (1980)

Twenty-one patients were studied in whom ventricular preexcitation (VP) had been recorded in the past and had later disappeared, indicating antegrade block in the accessory pathway (AP), either spontaneously (10 patients) or under the effect of chronic treatment with amiodarone (11 patients). VP reappeared in nine cases during vagal stimulation, and in five cases during an i.v. isoproterenol infusion. Retrograde conduction over the AP was studied in four of the remaining seven patients and was found to be present in three and absent in one. Although these patients differ from the ordinary patient with concealed AP in that antegrade preexcitation had been demonstrated in the past, this study suggests that concealed VP may result from the following mechanisms: 1) an extremely prolonged refractory period in the AP, causing a rate-dependent VP that can be identified during vagal stimulation; 2) a rate-independent depression of antegrade conduction that can be reversed by isoproterenol; 3) a depression of cond...
Re: Fruit and Vegetable Intake and Overall Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition
Authors: C. Bouchardy, S. Benhamou, E. Rapiti
Journal: JNCI Journal of the National Cancer Institute (2010)

Boffetta et al. (1) reported in the Journal a weak but statistically significant association between fruit and vegetable intake and the overall cancer risk by analyzing data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The reduced cancer risk associated with an increased daily intake of 200 g of fruits and vegetables combined was 3% (95% confidence intervals = 1% to 4%) only. The large health campaigns organized in several countries using TV commercials or other public media to encourage the population to eat five daily portions of fruits and vegetables at first seem disproportionate for such a small benefit. However, in our opinion, the associations that are limited to overall cancer risk are not sufficient to provide adequate information on the benefit of increased daily intake of fruits and vegetables for cancer prevention. Such associations should be assessed in the context of other EPIC results. Despite the weak association between fruit and vegetable intake and overall cancer risk, a strong association could be observed for some specific cancer sites, in particular among smokers. For breast, prostate, renal, and pancreatic cancers, previous EPIC results showed no association between fruit and vegetable intake and overall cancer risk (2–5). For epithelial ovarian, esophageal, and stomach cancers, the association was small or limited to some food items or histological subtypes of the tumors (6,7). For lung, upper aerodigestive, and colon cancers, the association was strong with the following results: 1) lung cancer risk was reduced by 40% in the highest vs the lowest quintile of fruit intake (8); the association between fruit and reduced cancer risk was particularly strong in Northern Europe, where the overall median intake of fruits and vegetables is lower than in other parts of Europe; 2) lung cancer risk was reduced in current smokers by 10% and 22%, per 100 g increase in daily intake of fruits and vegetables, respectively (9); 3) upper aerodigestive tract cancer risk was reduced by 9%, per 80 g increase in daily intake of fruits and vegetables combined (10); and 4) colon cancer risk was reduced by 24% in the highest vs the lowest quintile of fruits and vegetables combined (11). Because these cancers represent approximately 30% of cancers in men and 20% of cancers in women, the association between nutrition and overall cancer risk is diluted.
Lower Risk of Hepatocellular Carcinoma With Tenofovir vs Entecavir in Patients With Chronic Hepatitis B—in Reply
Authors: Jonggi Choi, Min Jung Ko, Young-Suk Lim
Journal: JAMA Oncology (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Correspondence on ‘EULAR recommendations for the management of antiphospholipid syndrome in adults’
Authors: Zhuochao Zhou, Fan Wang, Yue Sun, Jialin Teng, Honglei Liu, Xiaobing Cheng, Yutong Su, Hui Shi, Yijun You, Chengde Yang, Junna Ye
Journal: Annals of the Rheumatic Diseases (2020)

Correspondence on 'EULAR recommendations for the management of antiphospholipid syndrome in adults' 2019 antiphospholipid syndrome (APS) guideline 1 has been launched and has given recommendations to the rheumatologists on how to manage APS in different situations.The guideline has been presented in detail but there are still some questions remain to be discussed.For example, we are still confused in some circumstances, in secondary APS, such as systemic lupus erythematous, glucocorticoids (GC) is widely used.But according to the guideline in primary APS, GC treatment is recommended only in first trimester of pregnancy or in catastrophic APS (CAPS).But what about in second and third trimester of pregnancy?What dosage of GC is recommended?It needs more open discussion.In terms of CAPS, the definition has a strict request on biopsy.Yet, in the clinic practice, there are little chance to do the biopsy.Besides, thrombosis happened in 1 week is also a criterion hard to meet; sometimes, it could happen in more than 1 week.Is it possible that in the future, the definition of CAPS will be modified?Although we could give the diagnose of probable CAPS in these cases, patients are still in danger and have a great risk of severe complications, whose treatment should be similar to CAPS.For instance, GC and plasma exchange need to be used.Furthermore, the guideline did not recommend the choice of disease-modifying antirheumatic drugs in severe cases, is there a preference?More studies are needed to answer this question as well.Another circumstance is that patients with high-risk aPL profiles and new-onset thrombosis, besides heparin, is there a high-priority for GC and plasma exchange or intravenous immunoglobulins ?Moreover, in obstetric APS, another argument is that if a woman with positive medium-high titres of antiphospholipid antibodies, but with just once or twice spontaneous miscarriages (less than 10 weeks' gestation), meaning not meeting the APS classification criteria, what should be done, to use aspirin or not?For these older pregnant women, it sounds like a disaster to have another miscarriage without any intervention.Maybe these questions need more evidence and more clear explanation from experts.
Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment
Authors: Zhibo Xie, Ya Gao, Chiakang Ho, Lequn Li, Chen Jin, Xiaoyi Wang, Caifeng Zou, Yishen Mao, Xiaobo Wang, Qingfeng Li, Deliang Fu, Yi-Fan Zhang
Journal: Gut (2021)

Pancreatic ductal adenocarcinoma (PDAC) shows a remarkable predilection for liver metastasis. Pro-oncogenic secretome delivery and trafficking via exosomes are crucial for pre-metastatic microenvironment formation and metastasis. This study aimed to explore the underlying mechanisms of how PDAC-derived exosomes (Pex) modulate the liver microenvironment and promote metastasis.C57BL/6 mice were 'educated' by tail vein Pex injection. The intrasplenic injection liver metastasis and PDAC orthotopic transplantation models were used to evaluate liver metastasis. Stable cell lines CD44v6 (CD44 variant isoform 6) or C1QBP (complement C1q binding protein) knockdown or overexpression was established using lentivirus transfection or gateway systems. A total of 142 patients with PDAC in Huashan Hospital were retrospectively enrolled. Prognosis and liver metastasis were predicted using Kaplan-Meier survival curves and logistic regression models.Pex tail vein injection induced the deposition of liver fibrotic extracellular matrix, which promoted PDAC liver metastasis. Specifically, the exosomal CD44v6/C1QBP complex was delivered to the plasma membrane of hepatic satellite cells (HSCs), leading to phosphorylation of insulin-like growth factor 1 signalling molecules, which resulted in HSC activation and liver fibrosis. Expression of Pex CD44v6 and C1QBP in PDAC patients with liver metastasis was significantly higher than in PDAC patients without liver metastasis, and simultaneous high expression of exosomal CD44v6 and C1QBP correlated with a worse prognosis and a higher risk of postoperative PDAC liver metastasis.The Pex-derived CD44v6/C1QBP complex is essential for the formation of a fibrotic liver microenvironment and PDAC liver metastasis. Highly expressed exosomal CD44v6 and C1QBP are promising biomarkers for predicting prognosis and liver metastasis in patients with PDAC.
Abstract LB-024: Inactivation of the 25-hydroxyvitamin D(3)-1(alpha)-hydroxylase gene (CYP27B1): evidence for impaired vitamin D signaling in an MMTV-PYMT mouse model of breast cancer
Authors: Sylvester Jusu, John Presley, Bertrand Jean-Claude, Ursula Stochaj, Richard Kremer
Journal: Cancer Research (2019)

Abstract Purpose : The hormonally active form of vitamin D [1,25(OH)2D3], has several antitumor effects including antiproliferative, prodifferentiative and proapoptotic functions in tissues expressing and binding the vitamin D receptor. 1,25(OH)2D3 is synthesized from its precursor 25-hydroxyvitamin D [25(OH)D] via the catalytic action of the mitochondria cytochrome P450 enzyme 25(OH)D-1α-hydroxylase (CYP27B1). In the current study we investigated the role of CYP27B1 ablation on vitamin D signaling using the mouse mammary tumor virus promoter-driven polyoma middle T oncoprotein (MMTV-PyMT) mouse, an oncogene-driven model of highly aggressive spontaneous mammary tumors that closely mimics the estrogen receptor negative breast cancer in human disease. Methods: Tumors from animals were digested and primary cells were obtained from both CYP27B1 ablated AOH93Cre+ cells and wild type MT1107 Cre- control cells. The cells were next grown in complete DMEM medium, transfected with either a GFP-tagged human VDR or RXRα and treated with 1,25(OH)2D3 (10−7 mol/L) or 25(OH)D3 (10−7 mol/L) before data acquisition. Results: Using live and fixed cell fluorescence imaging, in situ proximity ligation assay and immunoblotting techniques, we show that the nuclear localization of both endogenous and exogenously tagged VDR and RXR were impaired in CYP27B1 ablated cells when compared to non-ablated cells. Furthermore, the intranuclear shuttling of VDR and its interaction with RXR were significantly reduced in CYP27B1 ablated cells as shown by both Florescence Recovery After Photobleaching and Fluorescence Resonance Energy Transfer techniques. Our results also show that CYP27B1 ablation disrupts VDR function by significantly impairing its nuclear localization, intranuclear transport, interaction with adaptor proteins, hVDR/hRXR, and this correlated with impaired binding to DNA and chromatin. Lastly, we demonstrate impaired induction of 53BP1, p65 and γ-H2AX DNA double-strand breaks in the CYP27B1 ablated cells compared to non-ablated cells. Conclusion: These results suggest that ablation of CYP27B1 results in dysregulation in vitamin D signaling which may impair its anticancer functions. Citation Format: Sylvester Jusu, John Presley, Bertrand Jean-Claude, Ursula Stochaj, Richard Kremer. Inactivation of the 25-hydroxyvitamin D(3)-1(alpha)-hydroxylase gene (CYP27B1): evidence for impaired vitamin D signaling in an MMTV-PYMT mouse model of breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr LB-024.
Endoscopic Vacuum Therapy as Treatment Option in Patients With Gastrointestinal Anastomotic Leakages
Authors: A Pyatakova, K Shishin, I Nedoluzhko, L Shumkina, N Kurushkina
Journal: Endoscopy (2021)

Aims Anastomotic leakage and associated mediastinitis and sepsis are serious complications after major abdominal interventions. The mortality rate in this group of patients measures up to 30 %. Nevertheless, traditional curative surgical interventions lead to an increase in mortality up to 64 %, which makes minimally invasive technologies beneficial.
Effect of atrial natriuretic factor on transmural myocardial blood flow distribution in the dog.
Authors: R PBauman, J CRembert, S IHimmelstein, P EKlotman, J CGreenfield
Journal: Circulation (1987)

These studies were designed to define the effect of atrial natriuretic peptide (ANP) on coronary flow. ANP was infused as a bolus directly into the left circumflex coronary artery in doses ranging from 0.05 to 5 micrograms in nine open-chest, anesthetized dogs. Coronary flow was measured with an electromagnetic flowmeter. Regional transmural myocardial blood flow and distribution were measured with 11.3 +/- 0.25 micron radionuclide-labeled microspheres. No significant change was noted in systemic hemodynamics (heart rate, arterial pressure, left atrial pressure, or cardiac output) during the course of the studies. ANP produced a transient vasodilatation of coronary resistance vessels and increased flow by 41% after both the 2.5 and 5 micrograms doses. The vasodilatation occurred uniformly throughout the ventricular wall so that the endocardial/epicardial flow ratio remained constant. There was no evidence of coronary vasoconstriction. The peak vasodilatation response occurred 28 +/- 7 sec after the beginn...
Epicardial strains in embryonic chick ventricle at stages 16 through 24.
Authors: L ATaber, HSun, E BClark, B BKeller
Journal: Circulation Research (1994)

Embryonic cardiac development depends, in part, on the local biomechanical environment. Tracking the motions of microspheres attached to the embryonic chick ventricle, we computed two-dimensional epicardial strains at Hamburger-Hamilton stages 16, 18, 21, and 24 (2.5, 3.5, 4.0, and 4.5 days, respectively, of a 21-day incubation period). First, in a cross-sectional study, strains were measured in separate embryos at each stage (n > or = 19 per stage). Then, in a longitudinal study, strains were measured serially on the same heart, with the eggs resealed and reincubated between successive stages (n > or = 4 per stage). Although the heart undergoes major changes in mass, morphology, and loading during the studied stages, both studies showed that peak circumferential and longitudinal strains relative to end diastole were similar in magnitude (0.13 to 0.16) and did not change significantly across the stage range. The peak principal strains also showed no significant changes, with magnitudes of approximately 0....
The effects of diltiazem and reduced serum ionized calcium on ischemic ventricular fibrillation in the dog.
Authors: W TClusin, M RBristow, D SBaim, J SSchroeder, PJaillon, PBrett, D CHarrison
Journal: Circulation Research (1982)

Calcium influx blockers reportedly suppress ventricular arrhythmias during acute ischemia. We therefore studied the effects of diltiazem and reduced serum ionized calcium on ventricular fibrillation (VF) in a reversible ligation model. VF was produced at 15-minute intervals by simultaneous occlusion of the left anterior descending and circumflex arteries of 31 dogs. Time from coronary occlusion to onset of VF showed no significant variation during 15 consecutive trials in six dogs that received saline alone. Intravenous infusion of diltiazem (0.02 mg/kg per min) markedly delayed the onset of VF in each of 10 dogs (P less than 0.0001). Mean VF latency increased from 138 to 295 seconds during a 45-minute diltiazem infusion, declined exponentially when the infusion ceased, and was strongly correlated with serum diltiazem concentration (r = 0.96, P less than 10(-6)). In five dogs, hemodynamic measurements, including coronary venous blood flow, were performed during each occlusion. The increase in VF latency b...
Correlation between in vivo transmembrane action potential durations and activation-recovery intervals from electrograms. Effects of interventions that alter repolarization time.
Authors: C WHaws, R LLux
Journal: Circulation (1990)

Classic cable theory was used to analyze the relation between the activation-recovery interval measured from unipolar electrograms and transmembrane action potential duration. Theoretic analysis demonstrated that the temporal derivative of the extracellular potential is proportional to a spatial weighting of the third temporal derivative of the transmembrane action potentials along a cable with uniform propagation in a homogeneous medium. Thus, the activation-recovery interval, measured as the interval between times of minimum derivative (Vmin) of the QRS and maximum derivative (Vmax) of the T wave, should be related to action potential duration, measured as the interval between times of Vmax of the upstroke and Vmin of the downstroke of the transmembrane action potential. This relation was examined experimentally in 12 anesthetized dogs. Unipolar electrograms and transmembrane action potentials were recorded simultaneously from sites within 2 mm of each other during control states, cardiac sympathetic ne...
Postextrasystolic alterations in refractoriness of the His-Purkinje system and ventricular myocardium in man.
Authors: M HLehmann, SDenker, RMahmud, MAkhtar
Journal: Circulation (1984)

The changes in refractoriness of the His-Purkinje system (HPS) and ventricular myocardium (VM) that are associated with the occurrence of postextrasystolic beats in man are unknown. Accordingly, using a pacing model of the cycle length changes created by a ventricular extrasystole-postextrasystole sequence, we measured retrograde HPS and VM relative and effective refractory periods (RRP and ERP) in 15 patients with the use of ventricular test extrastimuli during preextrasystolic basic control drive (method I) and after programmed extrasystolic (method II) and postextrasystolic (method III) beats. The basic cycle length (same for all three methods) ranged from 500 to 700 msec (mean 613 +/- 74 msec) and the extrasystolic coupling interval (identical for methods II and III) comprised 68 +/- 4% of the basic cycle length. In method III the postextrasystolic pause was programmed to equal the basic cycle length (i.e., noncompensatory) so that method I could serve as control for method III. RRP-HPS decreased from...
Retrograde nontransseptal balloon mitral valvuloplasty. Immediate results and long-term follow-up.
Authors: CStefanadis, CStratos, CPitsavos, IKallikazaros, FTriposkiadis, ATrikas, CVlachopoulos, IGavaliatsis, PToutouzas
Journal: Circulation (1992)

BACKGROUNDPercutaneous retrograde nontransseptal balloon mitral valvuloplasty is a new technique developed in our institution for opening a stenotic mitral valve. This technique is based on a new, externally steerable cardiac catheter that enters the left atrium retrogradely via the left ventricle.METHODS AND RESULTSThe technique was used in 86 consecutive patients (18 men and 68 women; mean age, 51 +/- 11 years). Dilatation of the stenotic mitral valve was achieved in 85 of the 86 patients. After the procedure, mitral valve area increased from 0.92 +/- 0.22 to 2.14 +/- 0.54 cm2 and transmitral gradient decreased from 16 +/- 6 to 5 +/- 2 mm Hg. Major complications, such as cardiac performation, embolic events, or death, were not encountered. Severe mitral regurgitation (greater than 2+) developed in three patients (3.5%). In two patients (2.4%), there was major injury of the femoral artery. The maintenance of the initial improvement was similar to that found in studies that used transseptal techniques. Th...