tbuckley/cabot-search huggingface dataset:
New Insights on the Treatment of Colorectal Peritoneal Metastases From the CAIRO6 Trial
Authors: Aditi Bhatt, Guillaume Passot, Olivier Glehen
Journal: JAMA Surgery (2021)

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Abstract 10412: Does High vs. Low Systolic Blood Pressure Response During Graded Exercise Testing Predict All-Cause and Cardiovascular Mortality?
Authors: Ahmad Barout, Amanda R Bonikowske, Sonia M Fortin, Maria Irene Barillas-Lara, Thomas G Allison
Journal: Circulation (2018)

Introduction: Normal blood pressure (BP) response to exercise is an increase in systolic blood pressure (SBP) and minimal diastolic change to accommodate the increased oxygen demand of skeletal mus...
Public Covid-19 X-ray datasets and their impact on model bias – A systematic review of a significant problem
Authors: Beatriz Garcia Santa Cruz, Matías Nicolás Bossa, Jan Sölter, Andreas Dominik Husch
Journal: Medical Image Analysis (2021)

Computer-aided-diagnosis and stratification of COVID-19 based on chest X-ray suffers from weak bias assessment and limited quality-control. Undetected bias induced by inappropriate use of datasets, and improper consideration of confounders prevents the translation of prediction models into clinical practice. By adopting established tools for model evaluation to the task of evaluating datasets, this study provides a systematic appraisal of publicly available COVID-19 chest X-ray datasets, determining their potential use and evaluating potential sources of bias. Only 9 out of more than a hundred identified datasets met at least the criteria for proper assessment of risk of bias and could be analysed in detail. Remarkably most of the datasets utilised in 201 papers published in peer-reviewed journals, are not among these 9 datasets, thus leading to models with high risk of bias. This raises concerns about the suitability of such models for clinical use. This systematic review highlights the limited description of datasets employed for modelling and aids researchers to select the most suitable datasets for their task.
1309P A multicenter phase I study of radium-223 (Ra-223) plus pembrolizumab in patients with stage IV non-small cell lung cancer (NSCLC)
Authors: M. Reck, K. Mileham, L. Paz-Ares, V. Surmont, E. Felip, N. Viñolas, A. Bessudo, D. Clump, L. Decoster, A. Estival, M. Sebastian, H. Chen, M. Chisamore, V.J. Wagner, A. Wagner, E.F.F. Smit
Journal: Annals of Oncology (2021)
1794P Rapid diagnosis of liquid biopsy in non-small cell lung cancer by the EGFR-LAMP assay
Authors: Y. Saito, A. Matsui, S. Michiyuki, H. Morooka, T. Ibi, Y. Yamauchi, N. Takahashi, Y. Shimizu, T. Ikeya, E. Hoshi, Y. Sakao, M. Kawamura
Journal: Annals of Oncology (2021)
1506MO Incorporating genetic and non-genetic risk factors in breast cancer risk prediction for healthy women with non-informative genetic test result
Authors: A. Tüchler, R. Remy, J. Dick, C. Ernst, B. Blümcke, I.M.M. Lakeman, C.J. van Asperen, P. Devilee, A. Brédart, K.E. Rhiem, D. Stoppa-Lyonnet, R.K. Schmutzler, E. Hahnen
Journal: Annals of Oncology (2021)
Drug Layering in Heart Failure
Authors: Giuseppe M.C. Rosano, Larry A. Allen, Amr Abdin, Joann Lindenfeld, Eileen O’Meara, Carolyn S.P. Lam, Patrizio Lancellotti, Gianluigi Savarese, Stephen S. Gottlieb, John Teerlink, Jan Wintrich, Michael Böhm
Journal: JACC Heart Failure (2021)
Accessibility of Medicare Diabetes Prevention Programs and Variation by State, Race, and Ethnicity
Authors: Alice Yan, Zhuo Chen, MinQi Wang, Carlos E. Mendez, Leonard E. Egede
Journal: JAMA Network Open (2021)

This cross-sectional study examines the accessibility of the Medicare Diabetes Prevention Program and investigates whether there are disparities in access among racial and ethnic minority beneficiaries at the state level.
Neutrophils in acute inflammation: current concepts and translational implications
Authors: Andreas Margraf, Clifford A. Lowell, Alexander Zarbock
Journal: Blood (2021)

Modulation of neutrophil recruitment and function is crucial for targeting inflammatory cells to sites of infection to combat invading pathogens while, at the same time, limiting host tissue injury or autoimmunity. The underlying mechanisms regulating recruitment of neutrophils, 1 of the most abundant inflammatory cells, have gained increasing interest over the years. The previously described classical recruitment cascade of leukocytes has been extended to include capturing, rolling, adhesion, crawling, and transmigration, as well as a reverse-transmigration step that is crucial for balancing immune defense and control of remote organ endothelial leakage. Current developments in the field emphasize the importance of cellular interplay, tissue environmental cues, circadian rhythmicity, detection of neutrophil phenotypes, differential chemokine sensing, and contribution of distinct signaling components to receptor activation and integrin conformations. The use of therapeutics modulating neutrophil activation responses, as well as mutations causing dysfunctional neutrophil receptors and impaired signaling cascades, have been defined in translational animal models. Human correlates of such mutations result in increased susceptibility to infections or organ damage. This review focuses on current advances in the understanding of the regulation of neutrophil recruitment and functionality and translational implications of current discoveries in the field with a focus on acute inflammation and sepsis.
1479P Exploring second-line therapy outcome in pancreatic ductal adenocarcinoma (PDAC) patients with germlineBRCA1-2 pathogenic variants (gBRCA1-2pv)
Authors: G. Orsi, M. Milella, F. Nappo, M. Di Marco, M. Niger, S. Bozzarelli, M.G. Rodriquenz, S. Noventa, G. Giordano, I.G. Rapposelli, I. Bernardini, E. Vasile, M. Macchini, U. Peretti, M.M. Valente, C. Paratore, A. Spallanzani, M. Scartozzi, S. Cascinu, M. Reni
Journal: Annals of Oncology (2021)
COVID-19 risk and mortality in hospitals: this is not a time to let our guard down
Authors: Jemima T Collins, Ben Carter, Jonathan Hewitt
Journal: Thorax (2021)

<h3>Rationale</h3> The influence of COPD exacerbation on the endothelium is not completely understood. Circulating endothelial microparticles (EMPs) are membrane vesicles in circulating blood that are shed by activated or apoptotic endothelial cells. <h3>Objective</h3> To compare EMP numbers in stable COPD patients with those during and after exacerbation. <h3>Methods</h3> We examined the EMP numbers in 80 stable COPD patients, 27 patients with exacerbated COPD, and 20 healthy non-COPD volunteers. EMPs were defined as CD144+ MPs (VE-cadherin EMPs), CD31+/CD41− MPs (PECAM EMPs), CD146 MPs (MCAM EMPs) and CD62E+ EMPs (E-selectin EMPs) as analysed by FACS. Von Willebrand factor (vWF) expression was utilised to identify the origins of the EMPs. <h3>Results</h3> VE-cadherin, PECAM and E-selectin EMP numbers were significantly higher in the stable COPD patients than in the non-COPD volunteers, and they were significantly higher in the patients with exacerbated COPD than in the stable COPD patients. The majority of these increased EMPs were vWF-negative, indicating a pulmonary capillary origin. Baseline E-selectin EMP levels were significantly higher in COPD patients who experienced frequent exacerbations than in those who did not have frequent exacerbations (p&lt;0.001). Twenty-eight days after the onset of exacerbation, E-selectin EMP levels returned to those observed in stable COPD patients, whereas PECAM EMP levels remained high. MCAM EMP numbers were not elevated in stable or exacerbated-COPD patients. <h3>Conclusions</h3> Endothelial damage, mainly in pulmonary capillaries, occurs during exacerbation and continues even after clinical symptoms disappear. Higher baseline E-selectin EMP levels may indicate COPD patients who are susceptible to exacerbation.
123MO BARBICAN: A randomized, phase II study to determine the contribution of ipatasertib to neoadjuvant chemotherapy plus atezolizumab in women with triple-negative breast cancer
Authors: P. Schmid, F.J. Salvador Bofill, B. Bermejo, M. Phillips, D. Wheatley, F. Neus, C. Schem, A. Stradella, M. Mele, A. Cortes Salgado, V. Quiroga, A. Antón Torres, A. Llombart Cussac, E. Zamora, G. Viale, S. Kuemmel, A. Prendergast, K. Mousa, O. Gluz, J. Cortés
Journal: Annals of Oncology (2021)
A retrospective analysis of diagnostic testing in a large North American cohort of patients with epidermolysis bullosa
Authors: Gregory Scott Phillips, Amy Huang, Bret D Augsburger, Laura Kaplan, Kathleen Peoples, Anna L Bruckner, Phuong Khuu, Jean Y Tang, Irene Lara-Corrales, Elena Pope, Karen Wiss, Laura E Levin, Kimberly D Morel, Kristen P Hook, Amy S Paller, Lawrence F Eichenfield, Catherine C McCuaig, Julie Powell, Leslie Castelo-Soccio, Moise L Levy, Harper N Price, Lawrence A Schachner, John C Browning, Marla Jahnke, Tor Shwayder, Susan Bayliss, Anne W Lucky, Sharon A Glick
Journal: Journal of the American Academy of Dermatology (2021)
Optimization of lipid nanoparticles for the delivery of nebulized therapeutic mRNA to the lungs
Authors: Melissa P. Lokugamage, Daryll Vanover, Jared Beyersdorf, Marine Z. C. Hatit, Laura Rotolo, Elisa Schrader Echeverri, Hannah E. Peck, Huanzhen Ni, Jeong-Kee Yoon, YongTae Kim, Philip J. Santangelo, James E. Dahlman
Journal: Nature Biomedical Engineering (2021)
1722P Prevalence and predictors of breast reconstruction following mastectomy in breast cancer patients treated in a public center in Mexico
Authors: A. Becerril-Gaitan, B.F. Vaca-Cartagena, A.S. Ferrigno, A. Aranda-Gutierrez, M. Roman-Zamudio, M.A. Acosta-Sandoval, M.I. Torres-Leal, F.A. Gonzalez-Mondellini, H.M. Diaz-Perez, S. Cardona-Huerta, R. Ortiz-López, C. Villarreal-Garza
Journal: Annals of Oncology (2021)
sEH promotes macrophage phagocytosis and lung clearance of Streptococcus pneumoniae
Authors: Hong Li, J. Alyce Bradbury, Matthew L. Edin, Joan P. Graves, Artiom Gruzdev, Jennifer Cheng, Samantha L. Hoopes, Laura M. DeGraff, Michael B. Fessler, Stavros Garantziotis, Shepherd H. Schurman, Darryl C. Zeldin
Journal: Journal of Clinical Investigation (2021)

Epoxyeicosatrienoic acids (EETs) have potent antiinflammatory properties. Hydrolysis of EETs by soluble epoxide hydrolase/ epoxide hydrolase 2 (sEH/EPHX2) to less active diols attenuates their antiinflammatory effects. Macrophage activation is critical to many inflammatory responses; however, the role of EETs and sEH in regulating macrophage function remains unknown. Lung bacterial clearance of Streptococcus pneumoniae was impaired in Ephx2-deficient (Ephx2–/–) mice and in mice treated with an sEH inhibitor. The EET receptor antagonist EEZE restored lung clearance of S. pneumoniae in Ephx2–/– mice. Ephx2–/– mice had normal lung Il1b, Il6, and Tnfa expression levels and macrophage recruitment to the lungs during S. pneumoniae infection; however, Ephx2 disruption attenuated proinflammatory cytokine induction, Tlr2 and Pgylrp1 receptor upregulation, and Ras-related C3 botulinum toxin substrates 1 and 2 (Rac1/2) and cell division control protein 42 homolog (Cdc42) activation in PGN-stimulated macrophages. Consistent with these observations, Ephx2–/– macrophages displayed reduced phagocytosis of S. pneumoniae in vivo and in vitro. Heterologous overexpression of TLR2 and peptidoglycan recognition protein 1 (PGLYRP1) in Ephx2–/– macrophages restored macrophage activation and phagocytosis. Human macrophage function was similarly regulated by EETs. Together, these results demonstrate that EETs reduced macrophage activation and phagocytosis of S. pneumoniae through the downregulation of TLR2 and PGLYRP1 expression. Defining the role of EETs and sEH in macrophage function may lead to the development of new therapeutic approaches for bacterial diseases.
ETV6-NCOA2 fusion induces T/myeloid mixed-phenotype leukemia through transformation of nonthymic hematopoietic progenitor cells
Authors: Hila Fishman, Shreyas Madiwale, Ifat Geron, Vase Bari, Wouter Van Loocke, Yael Kirschenbaum, Itamar Ganmore, Eitan Kugler, Avigail Rein-Gil, Gilgi Friedlander, Ginette Schiby, Yehudit Birger, Sabine Strehl, Jean Soulier, Birgit Knoechel, Adolfo Ferrando, Sharon Noy-Lotan, Arnon Nagler, James C. Mulloy, Pieter Van Vlierberghe, Shai Izraeli
Journal: Blood (2021)
LBA54 Ipilimumab or FOLFOX in combination with nivolumab and trastuzumab in previously untreated HER2 positive locally advanced or metastastic esophagogastric adenocarcinoma (EGA): Results of the randomized phase II INTEGA trial (AIO STO 0217)
Authors: A. Stein, L. Paschold, J. Tintelnot, E. Goekkurt, P.C. Thuss-Patience, S. Lorenzen, T.J. Ettrich, J. Riera Knorrenschild, L. Jacobasch, A. Kretzschmar, S. Kubicka, S-E. Al-Batran, A. Reinacher-Schick, D. Pink, M. Sinn, U. Lindig, A. Hinke, S. Hegewisch Becker, M. Binder
Journal: Annals of Oncology (2021)
Coding Variants in Susceptibility to Diabetic Kidney Disease
Authors: Lili Liu, Krzysztof Kiryluk
Journal: Journal of the American Society of Nephrology (2021)

Diabetic kidney disease (DKD) is the leading cause of ESKD in the United States. About a third of patients with type 1 diabetes will eventually suffer from kidney failure.[1][1] Genetic predisposition to DKD has been implicated by family-based studies[2][2],[3][3]; however, progress in gene mapping
Prevalence of SARS-CoV-2 Infections Among Students, Teachers, and Household Members During Lockdown and Split Classes in Berlin, Germany
Authors: Welmoed van Loon, Stefanie Theuring, Franziska Hommes, Marcus A. Mall, Joachim Seybold, Tobias Kurth, Frank P. Mockenhaupt
Journal: JAMA Network Open (2021)

This cohort study assesses the prevalence of SARS-CoV-2 among students, teachers, and household members during lockdown and split classes in 2021 in Berlin, Germany, and examines the association between pandemic restrictions and student health-related quality of life.
Abstract 16326: Electrospun Nanofiber-Based Scaffolds Containing Mitochondrial-Targeted Antioxidants Reduce Mitochondrial Oxidative Stress in Human Coronary Artery Endothelial Cells
Authors: Yasaman Hamedani, Rayane Teixeira, Peter Wipf, Sankha Bhowmick, Ruhul Abid
Journal: Circulation (2019)

Introduction: In order to recover from oxidative stress after myocardial infarction (MI), coronary endothelial cells (EC) require to have optimal levels of subcellular reactive oxygen species (ROS)...
1560O Prevalence and impact of COVID-19 sequelae on treatment pathways and survival of cancer patients who recovered from SARS-CoV-2 infection
Authors: A. Cortellini, E. Roldán, M.C. Carmona Garcia, R. Berardi, A. Sánchez, C. Martinez, A. Parisi, E. Jones, R.M. Bertulli, G. Rizzo, A. Guida, C. Chung, M.D. Bower, M. Betti, B. Vincenzi, O. Mirallas, F. Biello, P. Queirolo, A. Gennari, D.J. Pinato
Journal: Annals of Oncology (2021)
1120P The prognostic and predictive roles of Ki67 and functional imaging tests in patients (pts) with metastatic pheochromocytoma or paraganglioma (mPPGL) treated with chemotherapy
Authors: S.T. Pacheco, M.D. Donadio, J.M.R.M. O'Connor, V. De Miguel, P.M. Beltran, J. Huaman, M. Dioca, A. Bragagnoli, R.F. Weschenfelder, R.P. Riechelmann
Journal: Annals of Oncology (2021)
The landscape of tumor cell states and ecosystems in diffuse large B cell lymphoma
Authors: Chloé B Steen, Bogdan A Luca, Mohammad S Esfahani, Armon Azizi, Brian J Sworder, Barzin Y Nabet, David M Kurtz, Chih Long Liu, Farnaz Khameneh, Ranjana H Advani, Yasodha Natkunam, June H Myklebust, Maximilian Diehn, Andrew J Gentles, Aaron M Newman, Ash A Alizadeh
Journal: Cancer Cell (2021)
The interaction of Helicobacter pylori with cancer immunomodulatory stromal cells: New insight into gastric cancer pathogenesis
Authors: Jamshid Gholizadeh Navashenaq, Arezoo Gowhari Shabgah, Maciej Banach, Tannaz Jamialahmadi, Peter E. Penson, Thomas P. Johnston, Amirhossein Sahebkar
Journal: Seminars in Cancer Biology (2021)

Gastric cancer is the fourth most common cause of cancer-linked deaths in the world. Gastric tumor cells have biological characteristics such as rapid proliferation, high invasiveness, and drug resistance, which result in recurrence and poor survival. Helicobacter pylori (H. pylori) has been proposed as a first-class carcinogen for gastric cancer according to the 1994 world health organization (WHO) classification. One of the important mechanisms by which H. pylori affects the gastric environment and promotes carcinogenesis is triggering inflammation. H. pylori induces an inflammatory response and a plethora of different signal transduction processes, leading to gastric mucosal disturbance, chronic gastritis, and a multi-step complex pathway that initiates carcinogenesis. It seems undeniable that the interaction between various cell types, including immune cells, gastric epithelium, glands, and stem cells, is vital for the progression and development of carcinogenesis concerning H. pylori. The interactions of H. pylori with surrounding cells play a key role in cancer progression. In this review, we discuss the interplay between H. pylori and tumor-supportive cells, including mesenchymal stem cells (MSCs), cancer-associated fibroblasts (CAFs), tumor-associated macrophages (TAMs), and myeloid derived-suppressor cells (MDSCs) in gastric cancer. It is hoped that clarifying the specific mechanisms for 'cross-talk' between H. pylori and these cells will provide promising strategies for developing new treatments.
330TiP Trastuzumab deruxtecan (T-DXd; DS-8201) in HER2-positive (HER2+) and HER2-low expressing (HER-LE) metastatic breast cancer (MBC) with brain metastases (BM) and/or leptomeningeal carcinomatosis (LMC): DEBBRAH
Authors: M. Vaz Batista, J.M. Pérez-Garcia, A. Llombart Cussac, P. Cortez, M. Ruiz Borrego, J. De La Haba, J.M. Cejalvo, F. Racca, S. Servitja, S. Blanch, L. Lema, M. Galàn Garmaje, M. Fernández-Abad, A. Fernández, V. Iranzo, S. González-Santiago, M. Gion, M. Nave, J. Cortés, S. Braga
Journal: Annals of Oncology (2021)
578MO Phase Ib/II study of sabizabulin (VERU-111), an androgen receptor transport disruptor, in men with metastatic castration resistant prostate cancer (mCRPC) who failed an androgen receptor targeting agent (ARTA)
Authors: M.C. Markowski, M. Eisenberger, C.M. Pieczonka, R.H. Getzenberg, D. Rodriguez, K.G. Barnette, M.S. Steiner, D.R. Saltzstein, E.S. Antonarakis, R. Tutrone
Journal: Annals of Oncology (2021)
1355P Monitoring tumor growth rate to predict immune checkpoint inhibitors’ treatment outcome in advanced NSCLC
Authors: F.G. Dall'Olio, C. Parisi, L. Marcolin, S. Brocchi, C. Caramella, N. Conci, G. Carpani, F. Gelsomino, S. Ardizzoni, P.V. Marchese, A. Paccapelo, G. Grilli, R. Golfieri, B. Besse, A. Ardizzoni
Journal: Annals of Oncology (2021)
1854P Multicentric, comparative, retrospective study on the safety and efficacy of conventional chemotherapy in cirrhotic patients with gastrointestinal cancer
Authors: M. Ningarhari, M. Bertez, A. Ploquin, N. Bertrand, C. Desauw, S. Cattan, P. Catala, H. Vandamme, J. Wasselin, H. Lubret, C. Cheymol, S. Truant, G. Lassailly, V. Canva, A. Louvet, P. Mathurin, S. Dharancy, A. Turpin
Journal: Annals of Oncology (2021)
398P AI-powered whole-slide image analysis of tumor-infiltrating lymphocytes for prediction of prognosis in colorectal cancer
Authors: C. Park, Y. Lim, S. Song, S. Ahn, J. Ryu, H. Song, M. Ma, S. Park, S. Pereira, B.J. Aum, S. Shin, S. Cho, K. Paeng, D. Yoo, W. Jung, C-Y. Ock
Journal: Annals of Oncology (2021)
1687P Health-related quality of life in cancer patients treated with immune checkpoint inhibitors in randomized controlled trials: A systematic review and meta-analysis
Authors: A. Boutros, M. Bruzzone, E.T. Tanda, E. Croce, L. Arecco, F. Cecchi, P. Pronzato, M. Ceppi, M. Lambertini, F. Spagnolo
Journal: Annals of Oncology (2021)
Hybrid Palliation for Hypoplastic Left Heart Syndrome: Association With Contemporary Outcomes
Authors: Andrew B. Ho, Ines Hribernik, Daniel Shillaker, John Thomson, Abdul Salam, Nathalie Dedieu, Alessandro Giardini, Graham Derrick, Barry O’Callaghan, Jack Gibb, Francisco Gonzalez-Barlatay, Demitris Taliotis, Melonie Johns, Nicholas Hayes, James R. Bentham
Journal: Circulation (2021)
1688P Impact of immunotherapy on the risk of thromboembolic disease in patients with melanoma
Authors: D. Fernandez Garay, N. Blaya Boluda, L. Ortega Morán, J.Z. Benoit-Perejón, L. Jiménez Colomo, M. Lobo de Mena, T. Quintanar Verduguez, A.B. Rupérez Blanco, A.M. Martin Fernandez de Soignie, J. Rubio Pérez, C. Font Puig, B. Obispo Portero, C. Guirao Rubio, J. Bosque Moreno, M.C. Rosa Garrido, A. Muñoz Martín, M. Sánchez Cánovas
Journal: Annals of Oncology (2021)
A Modular Biomaterial Scaffold‐Based Vaccine Elicits Durable Adaptive Immunity to Subunit SARS‐CoV‐2 Antigens
Authors: Fernanda Langellotto, Maxence O. Dellacherie, Chyenne Yeager, Hamza Ijaz, Jingyou Yu, Chi‐An Cheng, Nikolaos Dimitrakakis, Benjamin T. Seiler, Makda S. Gebre, Tal Gilboa, Rebecca Johnson, Nadia Storm, Sarai Bardales, Amanda Graveline, Des White, Christina M. Tringides, Mark J. Cartwright, Edward J. Doherty, Anna Honko, Anthony Griffiths, Dan H. Barouch, David R. Walt, David J. Mooney
Journal: Advanced Healthcare Materials (2021)

The coronavirus disease 2019 (COVID-19) pandemic demonstrates the importance of generating safe and efficacious vaccines that can be rapidly deployed against emerging pathogens. Subunit vaccines are considered among the safest, but proteins used in these typically lack strong immunogenicity, leading to poor immune responses. Here, a biomaterial COVID-19 vaccine based on a mesoporous silica rods (MSRs) platform is described. MSRs loaded with granulocyte-macrophage colony-stimulating factor (GM-CSF), the toll-like receptor 4 (TLR-4) agonist monophosphoryl lipid A (MPLA), and SARS-CoV-2 viral protein antigens slowly release their cargo and form subcutaneous scaffolds that locally recruit and activate antigen-presenting cells (APCs) for the generation of adaptive immunity. MSR-based vaccines generate robust and durable cellular and humoral responses against SARS-CoV-2 antigens, including the poorly immunogenic receptor binding domain (RBD) of the spike (S) protein. Persistent antibodies over the course of 8 months are found in all vaccine configurations tested and robust in vitro viral neutralization is observed both in a prime-boost and a single-dose regimen. These vaccines can be fully formulated ahead of time or stored lyophilized and reconstituted with an antigen mixture moments before injection, which can facilitate its rapid deployment against emerging SARS-CoV-2 variants or new pathogens. Together, the data show a promising COVID-19 vaccine candidate and a generally adaptable vaccine platform against infectious pathogens.