tbuckley/cabot-search huggingface dataset:
Covid-19: Sanofi and GSK to seek regulatory authorisation for protein based vaccine
Authors: Elisabeth Mahase
Journal: BMJ (2022)

Covid-19: Sanofi and GSK to seek regulatory authorisation for protein based vaccine Elisabeth MahaseSanofi and GlaxoSmithKline's covid-19 vaccine has 57.9% (95% confidence interval 26.5% to 76.7%) efficacy against any symptomatic disease, the companies have reported.
Book Review The Mechanism of the Larynx . By V. E. Negus, M.S. London, F.R.C.S. England. Junior Surgeon for Diseases of the Throat and Nose, King's College Hospital, London. Late Arris and Gale Lecturer, Hunterian Prof. and Hunterian Medalist, Royal College of Surgeons of England. Published by C. V. Mosby Co., St. Louis, Mo. Price $13.50. Introduction by Sir Arthur Keith, F.R.S. 483 pages of text, 160 illustrations. Bibliography including references to 280 articles. 15 tables.
Journal: New England Journal of Medicine (1930)
Screening in Early Intervention Increases Autism Diagnoses
Authors: Anita Slomski
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Numeric Errors in Results and Discussion and Errors in Figure 3
Authors: Peter Wolf, Pablo Vieyra-Garcia
Journal: JAMA Dermatology (2019)

Pablo Vieyra-Garcia, PhD; Regina Fink-Puches, MD; Stefanie Porkert, MD; Roland Lang, PhD; Sophie Pöchlauer, MD; Gudrun Ratzinger, MD; Adrian Tanew, MD; Sylvia Selhofer, MD; Sator Paul-Gunther, MD; Angelika Hofer, MD; Alexandra Gruber-Wackernagel, MD; Franz Legat, MD; Vijaykumar Patra, MSc; Franz Quehenberger, PhD; Lorenzo Cerroni, MD; Rachael Clark, MD, PhD; Peter Wolf, MD
Mistreatment Experienced by Internal Medicine Residents—The More Things Change, the More They Stay the Same
Authors: Natalie L. Richmond, Lara Goitein
Journal: JAMA Internal Medicine (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Chemoprevention of cutaneous squamous cell carcinoma and its precursors in solid organ transplant recipients using topical sirolimus: A randomized, double-blind, placebo-controlled pilot trial
Authors: Sharene Chong, Ho Yi Wong, Ahmad Althabteh, Charlotte Cox, Paul H Stevenson, Susan Brown, Anthony Griffin, Nicole Isbel, Gregory Siller, H Peter Soyer, Helmut Schaider, Edwige Roy, Scott Campbell, Adele C Green, Kiarash Khosrotehrani
Journal: Journal of the American Academy of Dermatology (2022)
<i>QuickStats:</i> Age-Adjusted Percentage* of Adults Aged ≥18 Years Reporting Diabetic Retinopathy<sup>†</sup> Among Those with Prediabetes or Diagnosed Diabetes,<sup>§</sup> by Age Group — National Health Interview Survey,<sup>¶</sup> 2016–2017
Journal: MMWR Morbidity and Mortality Weekly Report (2019)
KEAP1 and TP53 Mutations in Lung Cancer: More Is Better. Reply to: “Survival Analysis of TP53 Co-Mutations Should Be Interpreted More Cautiously”
Authors: Stefano Scalera, Marco Mazzotta, Federico Cappuzzo, Gennaro Ciliberto, Marcello Maugeri-Saccà
Journal: Journal of Thoracic Oncology (2022)
Traumatic Hemobilia
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
JAMA Reference Directories
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Autobiography.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mixed signals about the mental health of the NHS workforce
Authors: Danielle Lamb, Neil Greenberg, Sharon A M Stevelink, Simon Wessely
Journal: The Lancet Psychiatry (2020)

expectations for service-user involvement and leadership in research proposals, and ensure that established bodies of research do not become barriers to authentic community-led innovation. 4,9Too often, funding processes re-inscribe existing hierarchies and established interventions by rewarding proposals that build on, and hew to, existing published work.High-risk high-reward funding streams are typically present in the basic and translational sciences or new research areas such as digital health, with such language rarely used to refer to or fund user-led innovations.To achieve deeper change, funders must be open to new ideas and new directions, guided by those on the receiving end of services.Is the above pipeline merely a pipe dream?Our belief is that senior researchers, large research centres, and training programmes could readily take the steps described above, including substantially greater hiring, mentoring, and support of under-represented students and researchers with lived experience.Were it a priority, research funding bodies could-with relatively minor modifications to programme announcements-
Omicron-Specific Cytotoxic T-Cell Responses After a Third Dose of mRNA COVID-19 Vaccine Among Patients With Multiple Sclerosis Treated With Ocrelizumab
Authors: Natacha Madelon, Nelli Heikkilä, Irène Sabater Royo, Paola Fontannaz, Gautier Breville, Kim Lauper, Rachel Goldstein, Alba Grifoni, Alessandro Sette, Claire-Anne Siegrist, Axel Finckh, Patrice H. Lalive, Arnaud M. Didierlaurent, Christiane S. Eberhardt
Journal: JAMA Neurology (2022)

The SARS-CoV-2 variant B.1.1.529 (Omicron) escapes neutralizing antibodies elicited after COVID-19 vaccination, while T-cell responses might be better conserved. It is crucial to assess how a third vaccination modifies these responses, particularly for immunocompromised patients with readily impaired antibody responses.To determine T-cell responses to the Omicron spike protein in anti-CD20-treated patients with multiple sclerosis (MS) before and after a third messenger RNA COVID-19 vaccination.In this prospective cohort study conducted from March 2021 to November 2021 at the University Hospital Geneva, adults with MS receiving anti-CD20 treatment (ocrelizumab) were identified by their treating neurologists and enrolled in the study. A total of 20 patients received their third dose of messenger RNA COVID-19 vaccine and were included in this analysis.Blood sampling before and 1 month after the third vaccine dose.Quantification of CD4 and CD8 (cytotoxic) T cells specific for the SARS-CoV-2 spike proteins of the vaccine strain as well as the Delta and Omicron variants, comparing frequencies before and after the third vaccine dose.Of 20 included patients, 11 (55%) were male, and the median (IQR) age was 45.8 (37.8-53.3) years. Spike-specific CD4 and CD8 T-cell memory against all variants were maintained in 9 to 12 patients 6 months after their second vaccination, albeit at lower median frequencies against the Delta and Omicron variants compared with the vaccine strain (CD8 T cells: Delta, 83.0%; 95% CI, 73.6-114.5; Omicron, 78.9%; 95% CI, 59.4-100.0; CD4 T cells: Delta, 72.2%; 95% CI, 67.4-90.5; Omicron, 62.5%; 95% CI, 51.0-89.0). A third dose enhanced the number of responders to all variants (11 to 15 patients) and significantly increased CD8 T-cell responses, but the frequencies of Omicron-specific CD8 T cells remained 71.1% (95% CI, 41.6-96.2) of the responses specific to the vaccine strain.In this cohort study of patients with MS treated with ocrelizumab, there were robust T-cell responses recognizing spike proteins from the Delta and Omicron variants, suggesting that COVID-19 vaccination in patients taking B-cell-depleting drugs may protect them against serious complications from COVID-19 infection. T-cell response rates increased after the third dose, demonstrating the importance of a booster dose for this population.
Metabolic subtypes of patients with NAFLD exhibit distinctive cardiovascular risk profiles
Authors: Ibon Martínez‐Arranz, Chiara Bruzzone, Mazen Noureddin, Ruben Gil‐Redondo, Itziar Mincholé, Maider Bizkarguenaga, Enara Arretxe, Marta Iruarrizaga‐Lejarreta, David Fernández‐Ramos, Fernando Lopitz‐Otsoa, Rebeca Mayo, Nieves Embade, Elizabeth Newberry, Bettina Mittendorf, Laura Izquierdo‐Sánchez, Vaclav Smid, Jorge Arnold, Paula Iruzubieta, Ylenia Pérez Castaño, Marcin Krawczyk, Urko M. Marigorta, Martine C. Morrison, Robert Kleemann, Antonio Martín‐Duce, Liat Hayardeny, Libor Vitek, Radan Bruha, Rocío Aller de la Fuente, Javier Crespo, Manuel Romero‐Gomez, Jesus M Banales, Marco Arrese, Kenneth Cusi, Elisabetta Bugianesi, Samuel Klein, Shelly C. Lu, Quentin M. Anstee, Oscar Millet, Nicholas O. Davidson, Cristina Alonso, José M. Mato
Journal: Hepatology (2022)

We previously identified subsets of patients with NAFLD with different metabolic phenotypes. Here we align metabolomic signatures with cardiovascular disease (CVD) and genetic risk factors.
Pulmonary tuberculosis in intensive care setting, with a focus on the use of severity scores, a multinational collaborative systematic review
Authors: J. Galvin, S. Tiberi, O. Akkerman, H.A.M. Kerstjens, H. Kunst, X. Kurhasani, N. Ambrosino, G.B. Migliori
Journal: Pulmonology (2022)

Tuberculosis (TB) is associated with a high mortality in the intensive care unit (ICU), especially in subjects with Acute Respiratory Distress Syndrome (ARDS) requiring mechanical ventilation. Despite its global burden on morbidity and mortality, TB is an uncommon cause of ICU admission, however mortality is disproportionate to the advances in diagnosis and treatment made. Herein we report a systematic review of published studies. Our Literature search was conducted to identify studies on outcomes of individuals with TB admitted to ICU. We report and review in-hospital mortality, predictors of poorer outcomes, usefulness of severity scoring systems and potential benefits of intravenous antibiotics. Searches from Pubmed, Embase, Cochrane and Medline were conducted from inception to March 2020. Only literature in English was included. Out of 529 potentially relevant articles, 17 were included. Mortality across all studies ranged from 29-95% with an average of 52.9%. All severity scores underestimated average mortality. The most common indication for ICU admission was acute respiratory failure (36.3%). Negative predictors of outcome included hospital acquired infections, need of mechanical ventilation and vasopressors, delay in initiation of anti-TB treatment, more than one organ failure and a higher severity score. Low income, high incidence countries showed a 23.4% higher mortality rate compared to high income, low TB incidence countries. Mortality in individuals with TB admitted to ICU is high. Earlier detection and treatment initiation is needed.
Transmission of and Infection With COVID-19 Among Vaccinated and Unvaccinated Attendees of an Indoor Wedding Reception in Minnesota
Authors: Haley Wienkes, Kelley Vilen, Alexandra Lorentz, Daniel Gerlach, Xiong Wang, Amy Saupe, Richard Danila, Ruth Lynfield, Kirk Smith, Carlota Medus
Journal: JAMA Network Open (2022)

<h3>Importance</h3> Characterizing rates of SARS-CoV-2 infection among vaccinated and unvaccinated persons with the same exposure is critical to understanding the association of vaccination with the risk of infection with the Delta variant. Additionally, evidence of Delta variant transmission by children to vaccinated adults has important public health implications. <h3>Objective</h3> To characterize transmission and infection of SARS-CoV-2 among vaccinated and unvaccinated attendees of an indoor wedding reception. <h3>Design, Setting, and Participants</h3> This cohort study included attendees at an indoor wedding reception in Minnesota in July 2021. Data were collected from REDCap surveys and routine surveillance interviews. The full list of attendees and a partial list of emails were obtained. Fifty-seven attendees completed the emailed survey. Eighteen additional attendees were identified from the state health department COVID-19 surveillance database. <h3>Exposures</h3> Attendance at an indoor event. <h3>Main Outcomes and Measures</h3> Risk of SARS-CoV-2 infection among vaccinated and unvaccinated attendees, identification of an index case, whole genome sequencing (WGS) to identify the COVID-19 variant, understanding of transmission patterns, and assessment of secondary transmission. The primary case definition was an individual with a positive SARS-CoV-2 test who attended the wedding in the 14 days prior to their illness. <h3>Results</h3> Data were gathered for 75 attendees (mean [SE] age, 37.5 [13.7] years; 57 [76%] female individuals), of whom 56 (75%) were fully vaccinated, 4 (5%) were partially vaccinated, and 15 (20%) were unvaccinated. Of 62 attendees who were tested, 29 (47%) tested positive, including 16 of 46 fully vaccinated attendees (35%), 2 of 4 partially vaccinated attendees (50%), and 11 of 12 unvaccinated attendees (92%). Being unvaccinated was associated with a higher risk of infection compared with being vaccinated (risk ratio, 2.64; 95% CI, 1.71-4.06;<i>P</i> = .001). One unvaccinated adult required hospitalization. An unvaccinated child who was symptomatic on the event date was identified as the index case. Eleven specimens were available for WGS. All sequenced specimens were closely related and were identified as the Delta variant. WGS supported secondary transmission from a vaccinated individual with SARS-CoV-2. <h3>Conclusions and Relevance</h3> This cohort study identified a COVID-19 Delta variant outbreak at an indoor event despite a high proportion of vaccinated attendees. It found that vaccination was associated with a reduced risk of infection.
ESGE Newsletter
Journal: Endoscopy (2010)

At GASTRO 2009 ESGE and OMED were jointly responsible for the endoscopic content of the London congress. Together, the two societies organized the numerous events at the Learning Area that began on Saturday noon with the Hands-on-Training on Biologic Models. In cooperation with ESGENA and with the support of corporate sponsors this operating theatre offers delegates the opportunity to perform various endoscopic techniques with personal doctor and nurse tutoring. The techniques included basic ERCP, EMR, upper and lower GI endoscopy, polypectomy, hemostasis, and use of short wire systems. In previous years the hands-on-training has been a main attraction in the Learning Area, and this year again all six 90-minute sessions were fully booked. A total number of 360 delegates were able to benefit from the volunteer expertise of the tutors and the generous support of the ESGE and OMED corporate partners on the weekend. Because the interest in hands-on-offerings was so strong, the ESGE and OMED wanted to extend practical educational training, and were happy to be able to involve additional industry partners in hands-on-presentations from Monday to Wednesday. The focus of these work-stations was on clip treatment, advanced GI endoscopy, ablation techniques on Barrett's esophagus and laparscopic and endoscopic simulator training. These sessions were open to all delegates on a walk-in basis. The seats were filled in the Lecture Theatre for all 15 talks given from Sunday to Wednesday. The objective of the small-forum speeches is to create a classroom scenario in which top experts in their fields present a topic before a small audience and encourage immediate discussion.
Environmental Injustice in North Carolina's Hog Industry
Authors: Steve Wing, Dana Cole, Gary Grant
Journal: Environmental Health Perspectives (2000)

Rapid growth and the concentration of hog production in North Carolina have raised concerns of a disproportionate impact of pollution and offensive odors on poor and nonwhite communities. We analyzed the location and characteristics of 2,514 intensive hog operations in relation to racial, economic, and water source characteristics of census block groups, neighborhoods with an average of approximately 500 households each. We used Poisson regression to evaluate the extent to which relationships between environmental justice variables and the number of hog operations persisted after consideration of population density. There are 18.9 times as many hog operations in the highest quintile of poverty as compared to the lowest; however, adjustment for population density reduces the excess to 7.2. Hog operations are approximately 5 times as common in the highest three quintiles of the percentage nonwhite population as compared to the lowest, adjusted for population density. The excess of hog operations is greatest in areas with both high poverty and high percentage nonwhites. Operations run by corporate integrators are more concentrated in poor and nonwhite areas than are operations run by independent growers. Most hog operations, which use waste pits that can contaminate groundwater, are located in areas with high dependence on well water for drinking. Disproportionate impacts of intensive hog production on people of color and on the poor may impede improvements in economic and environmental conditions that are needed to address public health in areas which have high disease rates and low access to medical care as compared to other areas of the state.
Endoscopic ultrasound and endoscopic submucosal dissection with a multitraction device for a colonic submucosal lesion
Authors: Lucile Héroin, Pierre Lafeuille, Tanguy Fenouil, Mathieu Pioche, Jérôme Rivory, Clara Yzet, Alexandru Lupu
Journal: Endoscopy (2022)

With the increasing number of screening colonoscopies performed, better bowel preparation, and advancements in endoscopic image quality, asymptomatic small lesions are detected more frequently. Where there is suspicion of a submucosal neuroendocrine tumor (NET), en bloc resection is advised [1] because complete resection allows for better histopathological characterization and, in low risk cases, no endoscopic follow-up.
WHAT MATTERS MOST TO PATIENTS WITH AORTIC STENOSIS? FRAMING THE CONVERSATION FOR SHARED DECISION MAKING
Authors: Megan Coylewright, Brian Lindman, Diana Otero, Aaron Horne, Christina Fitzpatrick, Melissa Levack, Long Ngo, Melissa Beaudry, Nananda Col
Journal: Journal of the American College of Cardiology (2021)