tbuckley/cabot-search huggingface dataset:
Treatment response and clinical outcomes of neuroendocrine neoplasms treated with immune checkpoint inhibitors: A single-institution experience.
Authors: Haley Hauser, Tiffany Le, Joanne F. Chou, Olivia Heffernan, April DeMore, Selin Gonen, Marinela Capanu, Diane Lauren Reidy, Nitya Prabhakar Raj
Journal: Journal of Clinical Oncology (2022)

506 Background: Immune checkpoint inhibitors (ICIs) have antitumor activity in some solid tumors, however a role for ICI’s in the treatment of neuroendocrine neoplasms (NENs) is uncertain. We analyzed response and outcomes of NENs, both well differentiated neuroendocrine tumors (WDNET) and poorly differentiated neuroendocrine carcinomas (PDNEC), treated with ICIs at Memorial Sloan Kettering Cancer Center during the past decade. Methods: Patients with NENs who received ICIs between 2010-2021 were identified. Demographics, pathology characteristics, treatment response and outcomes were recorded. Progression-free survival (PFS) and overall survival (OS) were estimated using Kaplan-Meier methods. Analysis of next-generation sequencing (NGS) results from archival tumor tissue was performed. Results: 57 patients with NENs treated with ICIs were identified (WDNET-16; PDNEC-41). All patients had heavily-treated metastatic disease (median number of prior systemic treatments, WDNET-4, PDNEC-2). Median time from diagnosis to ICI treatment was 41.5 months in WDNET, 8 months in PDNEC. WDNET response: 1 (6%) partial response (PR), 4 (25%) stable disease (SD), 10 (63%) progressive disease (PD). PDNEC response: 6 (15%) PR (5 microsatellite stable, 1 unknown), 3 (7%) SD, 32 (78%) PD. Median duration of ICI treatment: 2 months (range 0-27) in WDNET, 1 month (range 0-16) in PDNEC; median duration of treatment for the 7 responders was 11 months (range 2-27). While receiving ICIs, 3 PDNEC responders developed PD in an escape lesion (2 brain, 1 nodal) after response in all other disease sites and successfully continued ICI treatment post-RT of escape lesion. Six-month PFS was 20% [95%CI: 7%-55%] and 9.8% [95%CI: 4%-25%], OS 60% [95%CI: 40%-91%] and 37% [95%CI: 25%-56%], respectively in WDNET and PDNEC. NGS results were available in archival tumor tissue of 35 patients (61%); most common alterations were TP53 (20/26, 77%) and RB1 (14/26, 54%) in PDNEC versus ATM, SMAD4, CREBBP, and IRS2 (all 1/9, 11%) in WDNET. Conclusions: We observed limited activity for ICI’s in NEN treatment, primarily restricted to a subset of PDNEC. PFS/OS findings were consistent with historical data, reflecting the pathogenesis of distinct NEN subtypes.
Anesthesiology
Authors: Michael F. Roizen
Journal: JAMA (1990)

Many, if not most, anesthesiologists consider themselves primary care specialists—the internist in the operating room, the primary physician in the chronic pain setting, the physician without conflict of interest in the preoperative assessment of patients, and the physician interested in pain control and functional status recovery in the critical care and outpatient environments. Changes in each of these areas were introduced during the past year. "Smart" new technologies, such as the use of computers to turn one form of data (hemoglobin absorbance) into a clinically useful number (oxygen saturation), have been made part of practice guidelines. These new technologies and guidelines have improved the quality of anesthesia care, reduced its cost, and reduced malpractice premiums. As we enter a new decade, changing practice and research patterns in anesthesiology are evident. Injection of local anesthetics through interpleural catheters can be repeated to provide pain relief over long periods in patients with
A novel H129-based anterograde monosynaptic tracer exhibits features of strong labeling intensity, high tracing efficiency, and reduced retrograde labeling
Authors: Hong Yang, Feng Xiong, Hai-Bin Qin, Qun-Tao Yu, Jin-Yan Sun, Hai-Wen Zhao, Dong Li, Youtong Zhou, Fu-Kun Zhang, Xiao-Wen Zhu, Tong Wu, Man Jiang, Xiangmin Xu, Youming Lu, Hong-Jie Shen, Wen-Bo Zeng, Fei Zhao, Min-Hua Luo
Journal: Molecular Neurodegeneration (2022)

Viral tracers are important tools for mapping brain connectomes. The feature of predominant anterograde transneuronal transmission offers herpes simplex virus-1 (HSV-1) strain H129 (HSV1-H129) as a promising candidate to be developed as anterograde viral tracers. In our earlier studies, we developed H129-derived anterograde polysynaptic tracers and TK deficient (H129-dTK) monosynaptic tracers. However, their broad application is limited by some intrinsic drawbacks of the H129-dTK tracers, such as low labeling intensity due to TK deficiency and potential retrograde labeling caused by axon terminal invasion. The glycoprotein K (gK) of HSV-1 plays important roles in virus entry, egress, and virus-induced cell fusion. Its deficiency severely disables virus egress and spread, while only slightly limits viral genome replication and expression of viral proteins. Therefore, we created a novel H129-derived anterograde monosynaptic tracer (H129-dgK) by targeting gK, which overcomes the limitations of H129-dTK.Using our established platform and pipeline for developing viral tracers, we generated a novel tracer by deleting the gK gene from the H129-G4. The gK-deleted virus (H129-dgK-G4) was reconstituted and propagated in the Vero cell expressing wildtype H129 gK (gKwt) or the mutant gK (gKmut, A40V, C82S, M223I, L224V, V309M), respectively. Then the obtained viral tracers of gKmut pseudotyped and gKwt coated H129-dgK-G4 were tested in vitro and in vivo to characterize their tracing properties.H129-dgK-G4 expresses high levels of fluorescent proteins, eliminating the requirement of immunostaining for imaging detection. Compared to the TK deficient monosynaptic tracer H129-dTK-G4, H129-dgK-G4 labeled neurons with 1.76-fold stronger fluorescence intensity, and visualized 2.00-fold more postsynaptic neurons in the downstream brain regions. gKmut pseudotyping leads to a 77% decrease in retrograde labeling by reducing axon terminal invasion, and thus dramatically improves the anterograde-specific tracing of H129-dgK-G4. In addition, assisted by the AAV helper trans-complementarily expressing gKwt, H129-dgK-G4 allows for mapping monosynaptic connections and quantifying the circuit connectivity difference in the Alzheimer's disease and control mouse brains.gKmut pseudotyped H129-dgK-G4, a novel anterograde monosynaptic tracer, overcomes the limitations of H129-dTK tracers, and demonstrates desirable features of strong labeling intensity, high tracing efficiency, and improved anterograde specificity.
Correction to: Porphyromonas gingivalis infection promotes mitochondrial dysfunction through Drp1-dependent mitochondrial fission in endothelial cells
Authors: Tong Xu, Qin Dong, Yuxiao Luo, Yanqing Liu, Liang Gao, Yaping Pan, Dongmei Zhang
Journal: International Journal of Oral Science (2022)

1.The caption of Fig. 3c should be corrected from "DAPDH" to "GAPDH" 2. In the sentence on the second last line on page 2, "after 6 h of infection" should be changed to "after 12 h of infection".
Anticardiolipin, anticentromere and antiScl antibodies in patients with systemic sclerosis and severe digital ischaemia
Authors: C Hortas, G De Las, J Lopez-Arias, L Martin, F Pons-Romero
Journal: Annals of the Rheumatic Diseases (1995)

Letters to the editor/Correction months, which unmasked the diabetes and prompted its discontinuation, could have had a pathogenetic effect, although this point is speculative.Presumably gall stones were the initial cause of the acute pancreatitis; how- ever, we believe that they were not the cause of CCP, because a follow up CT scan failed to show them, and because gall stones are not a cause of chronic pancreatitis or CCP."In summary, we present two cases of CCP, one in a patient with SLE and SS, and the other in a patient with scleroderma, in which the usual causes of calcification chronic alcohol intake, nutritional deficiency, here- ditary pancreatitis, and chronic hypercalcaemia have been excluded.Because there was no definitive aetiological factor, this could be either idiopathic and unrelated to the rheumatic disease, or a real association with these collagen diseases.
<scp>PD‐L1</scp> overexpression correlates with <scp><i>JAK2</i>‐V617F</scp> mutational burden and is associated with 9p uniparental disomy in myeloproliferative neoplasms
Authors: Jelena D. Milosevic Feenstra, Roland Jäger, Fiorella Schischlik, Daniel Ivanov, Gregor Eisenwort, Elisa Rumi, Michael Schuster, Bettina Gisslinger, Sigrid Machherndl‐Spandl, Peter Bettelheim, Maria‐Theresa Krauth, Felix Keil, Christoph Bock, Mario Cazzola, Heinz Gisslinger, Robert Kralovics, Peter Valent
Journal: American Journal of Hematology (2022)

Abstract Myeloproliferative neoplasms (MPN) are chronic stem cell disorders characterized by enhanced proliferation of myeloid cells, immune deregulation, and drug resistance. JAK2 somatic mutations drive the disease in 50–60% and CALR mutations in 25–30% of cases. Published data suggest that JAK2 ‐V617F‐mutated MPN cells express the resistance‐related checkpoint PD‐L1. By applying RNA‐sequencing on granulocytes of 113 MPN patients, we demonstrate that PD‐L1 expression is highest among polycythemia vera patients and that PD‐L1 expression correlates with JAK2 ‐V617F mutational burden ( R = 0.52; p &lt; .0001). Single nucleotide polymorphism (SNP) arrays showed that chromosome 9p uniparental disomy (UPD) covers both PD‐L1 and JAK2 in all MPN patients examined. MPN cells in JAK2 ‐V617F‐positive patients expressed higher levels of PD‐L1 if 9p UPD was present compared to when it was absent ( p &lt; .0001). Moreover, haplotype‐based association analyses provided evidence for germline genetic factors at PD‐L1 locus contributing to MPN susceptibility independently of the previously described GGCC risk haplotype. We also found that PD‐L1 is highly expressed on putative CD34 + CD38 − disease‐initiating neoplastic stem cells (NSC) in both JAK2 and CALR ‐mutated MPN. PD‐L1 overexpression decreased upon exposure to JAK2 blockers and BRD4‐targeting agents, suggesting a role for JAK2‐STAT5‐signaling and BRD4 in PD‐L1 expression. Whether targeting of PD‐L1 can overcome NSC resistance in MPN remains to be elucidated in forthcoming studies.
Emile Vidal (1825-1893), Parisian dermatologist
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Shigella Hepatitis
Authors: Mark S. Stern
Journal: JAMA (1976)

SHIGELLOSIS, a common enteric infection, has not been known to be directly associated with hepatitis. However, hepatic disease has been implicated in conditions related to other bacterial species (such as<i>Salmonella typhi</i><sup>1</sup>) and typhoid hepatitis<sup>2</sup>; and even<i>Coxiella burnetti</i>(Q fever) is a rickettsial cause.<sup>3</sup>The following case report describes a patient with concomitant acute hepatitis and<i>Shigella</i>dysentery. <h3>Report of a Case</h3> An 18-year-old man was admitted to the hospital with diarrhea, fever, and abdominal pain. He had been in excellent health until approximately six days before admission, when he awoke with chills, a temperature of 40 C, nausea, and vomiting. Thereafter, a watery diarrhea developed, with up to 15 stools per day. There was no history of jaundice, intravenous drug abuse, phenothiazine use, ethanol abuse, shellfish ingestion, family history of liver disease, or known exposure to persons with hepatitis or jaundice. Blood pressure was 110/50
Abstract 265: Deficiency of Mir-1954 Promotes Cardiac Remodeling
Authors: Sudhiranjan Gupta, Ana P Takano, Rakeshwar Guleria
Journal: Circulation Research (2017)

Cardiac remodeling due to hemodynamic overload is associated with significant morbidity and mortality. In response to stress, cardiomyocyte (CM) become hypertrophied whereas cardiac fibroblasts convert into myofibroblasts. The phenomenon leads to the development of cardiac hypertrophy, fibrosis and impair cardiac function. Previously, we have shown the pivotal role of miRNA (a new class of post-transcriptional regulators) in cardiac remodeling, but, loss of miRNA contributing to the onset of cardiac remodeling remains elusive. Using next generation miRNA sequencing, we discovered a panel of novel dysregulated miRNAs from read-data, secondary structure and miRPara classification score analysis in wild-type mice (WT) infused with Angiotensin II (Ang II). Among them, one was identified as miR-1954, a novel miRNA which was significantly reduced in Ang II-infusion and transverse aortic constriction (TAC). Following an unbiased approach, we confirmed that Sp1-Gata4-Col I-Tsp1-axis is the bona-fide targets. Our hypothesis is that deficiency of miR-1954 exacerbates cardiac remodeling leading to hypertrophy and fibrosis through paracrine mechanism; and overexpression of miR-1954 mitigates the cardiac damage and abrogates remodeling by modulating Sp1-Gata4-Col I-Tsp1-axis. Our data demonstrated that depletion of miR-1954 in CM triggers hypertrophic response by modulating Sp1 and Gata4; releases soluble factors (Tgfβ1) that triggers cardiac fibroblasts proliferation; upregulation of thrombospondin 1 (Tsp1) and collagen I (Col I). Overexpression of miR-1954 in CM reverses these processes implicated a cellular cross-talk. Cardiac-specific overexpression of pre-miR-1954 transgenic mice (miR-1954 Tg) showed reduced cardiac mass and improved function compared to WT littermate after Ang II treatment. Inhibition of miR-1954 by locked nucleic acid of anti-miR-1954 exacerbates cardiac hypertrophy and fibrosis. Our findings provide evidence that loss of miR-1954 promotes cardiac remodeling by targeting Sp1-Gata4-Col I-Tsp1-axis and, overexpression of miR-1954 reverses the process. We conclude that miR-1954 could be a triggering factor in cardiac remodeling and providing new mechanistic information for therapeutic benefit.
Infant Mortality and Low Birth Weight Among Black and White Infants--United States, 1980-2000
Journal: JAMA (2002)

Despite substantial reductions in U.S. infant mortality during the past several decades, black-white disparities in infant mortality rates persist. One of the Healthy People 2010 national objectives for maternal and infant health is to reduce deaths among infants aged < 1 year to < or = 4.5 per 1,000 live births among all racial/ethnic groups (objective 16-1c). Important determinants of racial/ethnic differences in infant mortality are low birth weight (LBW), defined as < 2500 grams, and very low birth weight (VLBW), defined as < 1500 grams. High birth weight-specific mortality rates (BWSMRs) occur at these low birth weights. Healthy People 2010 goals include reducing LBW to 5% and VLBW to 0.9% of live births (objectives 16-10a and 16-10b, respectively). To assess progress toward meeting these national objectives, CDC analyzed birth and death certificate data from the National Center for Health Statistics. This report describes trends in mortality and birth weight among black and white infants, which indicate persistent black-white disparities and underscore the need for prevention strategies that reduce preterm delivery and specific medical conditions that lead to infant death.
Response to: ‘Correspondence on ‘Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19- associated cytokine storm syndrome: results of the CHIC study’’ by Klopfenstein<i>et al</i>
Authors: Robert BM Landewé, Sofia Ramiro, Rémy L M Mostard
Journal: Annals of the Rheumatic Diseases (2021)
TCT-60 Clinical Outcome of Preventive Angioplasty in ST-elevation Myocardial Infarction
Authors: Hyun Woo Park, HEE SOON PARK, Se Hun Kang, Sang Soo Cheon, Byeong Joo Bae, Min Su Kim, Jae Hyung Roh, Jung-Min Ahn, Mineok Chang, Sung-Han Yoon, Jong-Young Lee, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park
Journal: Journal of the American College of Cardiology (2014)
The serial intravascular ultrasound findings of a new biodegradable self-expanding coronary stents Hidenori Komori, Hideo Tamai, Keiji Igaki, Eisho Kyo, Kunihiko Kosuga, Tatsuhiko Hata, Masaharu Okada, Takuji Nakamura, Takafumi Tsuji, Shinsaku Takeda, Seiichiro Motohara, Hiromu Uehata. Shiga Medical Center for Adults, Moriyama, Japan
Journal: Journal of the American College of Cardiology (2001)
Thirtieth Annual Scientific Meeting of the American Society of Cytology
Journal: JNCI Journal of the National Cancer Institute (1982)

Thirtieth Annual Scientific Meeting of the American Society of Cytology JNCI: Journal of the National Cancer Institute, Volume 69, Issue 1, July 1982, Page 318, https://doi.org/10.1093/jnci/69.1.318-a Published: 01 July 1982
LONDON
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
1154-94 Effects of incomplete chest wall decompression during cardiopulmonary resuscitation on coronary and cerebral perfusion pressures in a porcine model of cardiac arrest
Authors: Demetris Yannopoulos, Gardar Sigurdsson, Scott McKnite, David Benditt, Tom Aufderheide, Ron Pirrallo, Terry Prove, Todd Zielinski, Keith G Lurie
Journal: Journal of the American College of Cardiology (2004)
Abstract P309: Social Network Analysis of Religious Organization Co-Affiliation, Exercise, and Weight in South Asians
Authors: Namratha R Kandula, Kayo Fujimoto, Yucheng Zhao, Alka M Kanaya, John A Schneider, Andrew Cooper, Ankita Puri, Swapna Dave, Juned Siddique
Journal: Circulation (2018)

Objective: Religious organizations may influence health behaviors by exerting social influence and reinforcing cultural beliefs. We tested the hypothesis that social influence, constituted by affiliating with or attending religious organizations, was associated with exercise and weight in South Asians. Methods: Multilevel, cross-sectional data were collected from participants in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study. Participants (n=700) were surveyed about their affiliation/membership in religious organizations (e.g., churches, temples, mosques) where South Asians participate using a comprehensive roster. MASALA participants who reported affiliating with or attending the same religious organization were classified as co-attendees. Body mass index (BMI) was calculated from measured height and weight, and physical activity (PA) was assessed using a validated questionnaire. The dependent variables were BMI categories (normal and overweight/obese), and meeting the minimum recommended amount of exercise (≥500 metabolic-minutes/week of moderate-vigorous PA). The main independent variable was affiliation exposure, a measure of the level of exposure to overweight/obesity and PA level among co-attendees at religious organizations, which is an indicator of social influence. Exponential random graph models were conducted to examine associations between exposure to co-attendees’ overweight/obesity and PA and individuals’ overweight/obesity and PA. Models controlled for individual-level sociodemographic, cultural, and network characteristics. Results: Participants (average age 59 years, SD=9 and 43% female) affiliated with 163 unique religious organizations, and the median number of affiliations was 3 (IQR 2-7). Participants were significantly more likely to be overweight/obese (aOR=2.3, 95% CI=1.1, 4.8) as they were increasingly exposed to other overweight/obese participants through co-affiliation in religious organizations. Individual-level network characteristics (e.g., number of overweight/obese friends/family) were not associated with overweight/obesity. Co-affiliation in religious organizations was not associated with PA; however participants with less traditional South Asian cultural beliefs were more likely to exercise at least 500 met-min/week (aOR=2.5, 95% CI= 1.4, 4.7) than those who held more traditional cultural beliefs. Conclusion: South Asians who were exposed to other overweight/obese South Asians through co-affiliation in religious organizations were more likely to be overweight/obese. These results provide evidence of multilevel social and cultural influences on health. Lifestyle interventions that address social and cultural drivers of behaviors and are implemented in partnership with religious organizations could be effective at reducing CVD risk in South Asians.
Identificadas las principales manifestaciones en la piel de la COVID‐19
Journal: British Journal of Dermatology (2020)

La enfermedad COVID-19 es una infecci on provocada por SARS-CoV-2.Se descubri o en diciembre de 2019, y en marzo de 2020 la Organizaci on Mundial de la Salud anunci o que ocasionaba una pandemia.La enfermedad puede afectar a varios organos y algunas descripciones previas indicaban que puede afectar a la piel.Los investigadores, dermat ologos de toda España, revisaron 375 casos con COVID-19 sospechado o confirmado, para desarrollar una clasificaci on de las lesiones que se asocian a COVID-19 y aportar im agenes.Las lesiones de los primeros 120 casos fueron revisadas por cuatro dermat ologos, sin conocer otra informaci on cl ınica, para reconocer los patrones de lesiones que se asocian con la COVID-19.Luego aplicaron estos patrones al resto de im agenes, mientras se mejoraban.De esta forma se describieron 5 grandes tipos de lesiones.Los grupos son: lesiones que parecen sabañones, brotes de pequeñas ves ıculas, ronchas, erupciones elevadas rojizas y lesiones de livedo o necrosis.La livedo son manchas que se producen por una alteraci on de la circulaci on de la sangre en la piel, mientras la necrosis es la muerte prematura de tejidos.Estos signos de COVID-19 se asocian con diferentes grados de gravedad de la enfermedad: las lesiones que parecen sabañones aparecen en las formas menos graves y la livedo o necrosis en los m as graves.