tbuckley/cabot-search huggingface dataset:
Abstract 11158: Clinical Impact of Concomitant MR Among Patients Undergoing Transcatheter Aortic Valve Replacement
Authors: Aamir Twing, Helena Dickens, Sanket Gokhale, Nicole Cho, Erik Simon, Brody D Slostad, Mayank M Kansal, Adhir R Shroff, Elliott Groves
Journal: Circulation (2021)

Background: Mitral regurgitation (MR) is seen in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR). However, clinical outcomes in these patients have varied. The purpose of this study is to assess outcomes and changes in EF after TAVR in patients with concomitant MR. Methods: Retrospective chart review from March 2018-June 2020 identified all TAVR patients from the University of Illinois, Chicago. MR was assessed as none, mild, moderate, or severe regurgitation on baseline transthoracic echocardiogram. Patients were included if they demonstrated 6 or 12-month follow-up after valve replacement. Outcomes included all-cause mortality, major adverse cardiovascular events (MACE), clinically significant bleeding, and improvement in EF category, which included normal (50-70%), mildly (40-49%), moderately (30-39%), or severely (&lt;30%) reduced. Results: 118 patients (age 76±10 years, 79% male, 46% white) followed up at 6-months and 112 at 12-months. Of these, 33% had baseline MR with 79% being mild and 21% moderate. Patients with AS+MR were more likely to have atrial fibrillation (41.0 vs. 19.0%, p=0.01) and an EF&lt;50% (33.3 vs. 8.9%, p=0.001) compared to those with AS only. After TAVR, patients with MR were more likely to show improvements in EF category at 6 months (19.4 vs. 5.5%, p=0.039, Fig. 1). In those with AS+MR vs. AS only, there were no differences in all-cause mortality (12.8 vs. 5.1%, p=0.14), MACE (17.9 vs. 8.9%, p=0.15), or bleeding (10.3 vs. 6.3%, p=0.45) at 6 months. There were also no differences in all-cause mortality (16.2 vs. 14.7%, p=0.83), MACE (24.3 vs. 20.0%, p=0.60), or bleeding (13.5 vs. 10.7%, p=0.66) at 12 months. Conclusion: At 6 and 12 months after TAVR, patients with AS+MR experienced similar clinical outcomes as compared to those with only AS. Patients with AS+MR were more likely to show increases in EF 6 months after valve replacement. Our results suggest that patients with AS+MR stand to benefit after TAVR.
Preliminary Results of the Filo Phase 2 Trial for Untreated Fit Patients with Intermediate Risk Chronic Lymphocytic Leukemia Comparing Ibrutinib Plus Venetoclax (IV) Versus FCR
Authors: Anne-Sophie Michallet, Anne Quinquenel, Remi Letestu, Magali Le Garff-Tavernier, Fabien Subtil, Mad-Helenie Elsensohn, Therese Aurran, Kamel Laribi, Florence Cymbalista, Vincent Levy, Laurence Simon, Damien Roos-Weil, Veronique Leblond, Marie-Sarah Dilhuydy, Cécile Tomowiak, Caroline Dartigeas, Romain Guieze, Olivier Tournilhac, Emmanuelle Ferrant, Sophie de Guibert, Pierre Feugier, Fatiha Merabet, Stéphane Leprêtre, Philippe Carassou, Julie Gay, Bénédicte Hivert, Luc Mathieu Fornecker, Jehan Dupuis, Lysiane Molina, Bruno Villemagne, Guillaume Cartron, Bernard Drenou, Béatrice Mahé, Omar Benbrahim, Xavier Cahu, Christelle Portois, Loic Ysebaert, Florence Nguyen-Khac, Valérie Rouille, Alain Delmer
Journal: Blood (2021)
Molecular Profiling Feasibility on Cell-Free Tumoral DNA in Relapse/Refractory (R/R) Multiple Myeloma (MM) Patients Screened for Phase I Trials
Authors: Cyril Quivoron, Helene Lecourt, Jean-Marie Michot, Julien Lazarovici, Julien Rossignol, David Ghez, Veronique Vergé, Veronique Saada, Alina Danu, Vincent Ribrag
Journal: Blood (2021)
Efficacy of Ibrutinib, Rituximab and Mini-CHOP in Very Elderly Patients with Newly Diagnosed Diffuse Large B Cell Lymphoma: Primary Analysis of the Australasian Leukaemia &amp; Lymphoma Group NHL29 Study
Authors: Emma Verner, Amanda Johnston, Nalini Pati, Eliza Hawkes, Hui-Peng Lee, Tara Cochrane, Chan-Yoon Cheah, Robin J Filshie, Duncan Purtill, Hanlon Sia, Anoop Kumar Enjeti, Christina Brown, Nicholas E. Murphy, Jennifer Curnow, Kenneth Lee, Mannu Walia, Belinda Butcher, Judith Trotman
Journal: Blood (2021)
Simplified risk-prediction for benchmarking and quality improvement in emergency general surgery. Prospective, multicenter, observational cohort study
Authors: C. Villodre, L. Taccogna, P. Zapater, M. Cantó, L. Mena, J. M. Ramia, F. Lluís, N. Afonso, V. Aguilella, J. Aguiló, J. C. Alados, M. Alberich, A. B. Apio, R. Balongo, E. Bra, A. Bravo-Gutiérrez, F. J. Briceño, J. Cabañas, G. Cánovas, I. Caravaca, S. Carbonell, E. Carrera-Dacosta, E. E Castro, C. Caula, E. Choolani-Bhojwani, A. Codina, S. Corral, C. Cuenca, Y. Curbelo-Peña, M. M. Delgado-Morales, L. Delgado-Plasencia, E. Doménech, A. M. Estévez, A. M. Feria, M. A. Gascón-Domínguez, R. Gianchandani, C. González, R. J. Hevia, M. A. González, J. M. Hidalgo, M. Lainez, N. Lluís, F. López, J. López-Fernández, J. A. López-Ruíz, P. Lora-Cumplido, Z. Madrazo, J. Marchena, Marenco B. de la Cuadra, S. Martín, Martínez I. Casas, P. Martínez, A. Mena-Mateos, D. Morales-García, C. Mulas, E. Muñoz-Forner, A. Naranjo, A. Navarro-Sánchez, I. Oliver, I. Ortega, R. Ortega-Higueruelo, S. Ortega-Ruiz, J. Osorio, M. H. Padín, J. J. Pamies, M. Paredes, F. Pareja-Ciuró, J. Parra, C. V. Pérez-Guarinós, B. Pérez-Saborido, J. Pintor-Tortolero, K. Plua-Muñiz, M. Rey, I. Rodríguez, C. Ruiz, R. Ruíz, S. Ruiz, A. Sánchez, D. Sánchez, R. Sánchez, F. Sánchez-Cabezudo, R. Sánchez-Santos, J. Santos, M. P. Serrano-Paz, V. Soria-Aledo, L. Tallón-Aguilar, J. H. Valdivia-Risco, H. Vallverdú-Cartié, C. Varela, J. Villar-del-Moral, N. Zambudio
Journal: International Journal of Surgery (2021)
CD19+ B Lymphocytes Are Predictive for Anti-Sars-Cov-2 Vaccination Response in Multiple Myeloma Patients
Authors: Susanne Ghandili, Martin Schönlein, Heiko Becher, Christian Wiessner, Marc Lütgehetmann, Julian Schulze zur Wiesch, Carsten Bokemeyer, Marianne Sinn, Lisa Leypoldt, Katja Weisel
Journal: Blood (2021)
Abstract PO-028: Pancreatic ductal adenocarcinoma is dependent on an unconventional pathway for polyamine synthesis
Authors: Min-Sik Lee, Insia Naqvi, Courtney Dennis, Lucas Dailey, Alireza Lorzadeh, Tamara Zaytouni, Ashley Adler, Daniel S. Hitchcock, Lin Lin, Unmesh Jadhav, Clary B. Clish, Nada Y. Kalaany
Journal: Cancer Research (2021)

Abstract Targeting altered metabolism in pancreatic ductal adenocarcinoma (PDAC) has been an area of extensive investigation for over a decade now. A major hurdle however, for most anti-tumor metabolic strategies, is the high risk for toxicity, given the essential roles of metabolic pathways in the maintenance of normal tissue homeostasis. Indeed, this has been the case for targeting polyamines in cancers. Polyamines are small, highly positively charged molecules involved in multiple fundamental processes of cell growth and survival, including the synthesis of nucleic acids, modifications of chromatin structure, gene transcription and mRNA translation. Polyamine levels are significantly increased in many cancers, including PDAC. Prior anti-tumor strategies focused on pharmacological inhibition of the rate-limiting enzyme of polyamine synthesis, ornithine decarboxylase (ODC1) with little success, partially due to risk of harming normal tissues at higher drug doses. In this project, using both in vitro and in vivo mouse models of PDAC, we identified a dependency of PDAC on an unconventional way for the synthesis of the polyamine precursor ornithine, specifically from glutamine via ornithine aminotransferase (OAT); this is in contrast to its synthesis in most adult normal tissues from arginine via arginase (ARG) activity. We also identified potential key players mediating the induction of this metabolic pathway via KRAS, the main oncogenic driver in PDAC and are currently characterizing the downstream effects of polyamines on pancreatic tumor cells. The high dependency of PDAC, compared to normal tissue, on de novo ornithine synthesis via OAT provides an attractive therapeutic window for treating pancreatic cancer patients with minimal toxicity. Citation Format: Min-Sik Lee, Insia Naqvi, Courtney Dennis, Lucas Dailey, Alireza Lorzadeh, Tamara Zaytouni, Ashley Adler, Daniel S. Hitchcock, Lin Lin, Unmesh Jadhav, Clary B. Clish, Nada Y. Kalaany. Pancreatic ductal adenocarcinoma is dependent on an unconventional pathway for polyamine synthesis [abstract]. In: Proceedings of the AACR Virtual Special Conference on Pancreatic Cancer; 2021 Sep 29-30. Philadelphia (PA): AACR; Cancer Res 2021;81(22 Suppl):Abstract nr PO-028.
Pelabresib (CPI-0610) Monotherapy in Patients with Myelofibrosis - Update of Clinical and Translational Data from the Ongoing Manifest Trial
Authors: Marina Kremyanskaya, John Mascarenhas, Francesca Palandri, Alessandro Vannucchi, Srdan Verstovsek, Claire N. Harrison, Prithviraj Bose, Gary J. Schiller, Raajit Rampal, Mark W. Drummond, Vikas Gupta, Andrea Patriarca, Nikki Granacher, Joseph Scandura, Witold Prejzner, Lino L. Teichmann, Natalia Curto-Garcia, Ronald Hoffman, Gozde Colak, Zheng Ren, Suresh Bobba, Jike Cui, Sergey Efuni, Moshe Talpaz
Journal: Blood (2021)
Performance of Next Generation Sequencing for Minimal Residual Disease Detection for Pediatric Patients with Acute Lymphoblastic Leukemia: Results from the Prospective Clinical Trial DFCI 16-001
Authors: Jonathan D. Paolino, Marian H. Harris, Kristen E. Stevenson, Victoria Koch, Peter D. Cole, Lisa M. Gennarini, Justine M. Kahn, Kara M. Kelly, IIan Kirsch, Bruno Michon, Andrew E. Place, Thai Hoa Tran, Jennifer J.G. Welch, Lewis B. Silverman
Journal: Blood (2021)
Abstract 9063: Global Longitudinal Strain and Longitudinal Early Diastolic Strain Rate May Identify Those Williams Syndrome Patients at Risk of Cardiomyopathy Development
Authors: Marie L Carillo, Mark D Levin, Christopher F Spurney, Beth A Kozel
Journal: Circulation (2021)

Introduction: Williams syndrome (WS) is a rare disease caused by a chromosomal microdeletion at 7q11.23 resulting in elastin insufficiency and vascular disease, most commonly supravalvar aortic stenosis. Previous studies show WS patients are at risk for cardiomyopathy, but, to date, no markers predict such disease. This study was designed to test the hypothesis that WS left ventricular (LV) longitudinal strain and longitudinal early diastolic strain rate differ significantly from controls and may identify those at risk of cardiomyopathy development. Methods: Echocardiograms were performed in 43 WS subjects and equal numbers of sex, age and BSA-matched controls enrolled in a prospective cross-sectional NIH study of end organ WS disease (ClinicalTrials.gov Identifier: NCT0284044). Myocardial strain analysis was performed using TomTec software by two independent observers to determine global longitudinal peak systolic strain (GLS) and early diastolic peak strain rate (DSR) in the apical 4 chamber view (A4C). Mann Whitney test was used for all comparisons. Results: WS subject mean cohort ages (years) were: group A: 7±2, n=12; group B: 13±2, n=11; group C: 26±2, n=10; group D: 48±9, n=10, and matched control mean age and sample size were not different. All subjects had ejection fraction&gt;55%. Groups C and D WS subjects showed significantly diminished median GLS (%) compared to controls (Fig 1A): C: -20.6 vs. -24.6, P&lt;0.04; D: -22.4 vs. -25.5, P&lt;0.04. DSR (1/s) was significantly decreased in all WS age groups (P&lt;0.02) and decreased with age compared to controls (Fig 1B): 1.25 vs. 2.2 to 0.9 vs. 1.0. Conclusion: WS subjects demonstrate decreased DSR indicating diminished diastolic function from childhood. GLS differences appeared in adulthood, possibly indicating early systolic impairment. This data suggests GLS and DSR may be useful in targeting therapies towards those WS patients at greatest risk of cardiomyopathy development.
Calcium Phosphate‐Coated and Strontium‐Incorporated Mesoporous Silica Nanoparticles Can Effectively Induce Osteogenic Stem Cell Differentiation
Authors: Pichaporn Sutthavas, Zeinab Tahmasebi Birgani, Pamela Habibovic, Sabine van Rijt
Journal: Advanced Healthcare Materials (2021)

Ceramic (nano)materials are promising materials for bone regeneration applications. The addition of bioinorganics such as strontium (Sr) and zinc (Zn) is a popular approach to further improve their biological performance. However, control over ion delivery is important to prevent off-target effects. Mesoporous silica nanoparticles (MSNs) are popular nanomaterials that can be designed to incorporate and controllably deliver multiple ions to steer specific regenerative processes. In this work, MSNs loaded with Sr (MSN
Abstract 14037: A Shorter Myosin Light Chain Kinase 3 Isoform Maintains Myosin Light Chain 2 Phosphorylation but Does Not Attenuate the Dilated Cardiomyopathy Seen in C57BL/6N Mice
Authors: Jack Williams, anju paudyal, Michelle Stewart, Pedro Cutillas, Roger D Cox, Andrew Tinker, Lou Metherell
Journal: Circulation (2021)

Introduction: The C57BL/6J and C57BL/6N are two of the most commonly used mouse strains in biological research. We recently discovered C57BL/6N males develop a modest dilated cardiomyopathy (DCM) by 12 months, which is absent from the closely related C57BL/6J. We identified a variant (Chr8:85365179A&gt;T, c.-5T&gt;A) in myosin light chain kinase 3 ( Mylk3 ) in the 5’ UTR of the primary isoform resident to C57BL/6N substrains, which abolishes translation of this isoform. Myosin light chain 2 (MYL2) is the primary target of MYLK3, and its phosphorylation is vital for survival. Hypothesis: Loss of MYLK3 expression alters phosphorylation of key cardiac proteins. Results: Surprisingly, we found no difference in MYL2 phosphorylation by western blot between C57BL/6N and C57BL/6J hearts, at any of the reported target residues. Phosphoproteomics corroborated this, but highlighted significantly different phosphorylation at a number of phosphosites in other proteins linked to cardiomyopathies and cardiac development, particularly a reduction of a number of residues in ACTN2. We also detected peptide sequences that mapped to the C-terminus and middle of MYLK3 in the C57BL/6N. Western blotting with a C-terminal specific antibody revealed expression of a shorter isoform, present at lower levels in both strains, that is unaffected by the variant due to a distinct N-terminus. Using this antibody in IHC showed similar spatial expression of MYLK3 in hearts from both strains, localizing to the Z-disc, although the expression was much lower in the C57BL/6N presumed to be due to lack of the more abundant full-length isoform. Using immunoprecipitation, we found both isoforms bound to MYL2 in vivo and in vitro , and both were capable of phosphorylating MYL2 in vitro. However, the shorter isoform was not as readily bound to alpha-actinin-2 (ACTN2), a key sarcomeric protein that is reported to bind full-length MYLK3 isoform by its N-terminus. Conclusions: This data indicates loss of full-length MYLK3 causes DCM via a MYL2-independent mechanism, possibly due to lack of phosphorylation of alternative target(s), such as ACTN2. The expression of the shorter MYLK3 isoform in C57BL/6N mice may explain the persistence of MYL2 phosphorylation in these mice and enable their survival.
Doxorubicin, Etoposide, Vinblastine and Dacarbazine (AEVD) for Newly Diagnosed Classic Hodgkin Lymphoma
Authors: Marcelo Pitombeira de Lacerda, Julio Cesar de Oliveira, Sergio Jungles, Gabriela Sirydakis Macedo, Ana Paula Tomazelli, Joao Pedro Ribeiro Baptista, Ana Claudia Dall'Oglio, Gabriela Roncone Gastal, Ivan Schneider Boettcher, Fabiana Sanchez Tavares, Soraya Dobner
Journal: Blood (2021)
Higher Skeletal Muscle Index Is Associated with Improved Overall Survival in Older Patients with Sarcopenia Undergoing Allogeneic Stem Cell Transplant
Authors: Charles Gaulin, Blake T. Langlais, Luke Mountjoy, Panagiotis Korfiatis, Nelly Tan, Jose F. Leis, Nandita Khera, Pierre Noel, Lisa Z. Sproat, Tania Jain, Jeanne M. Palmer
Journal: Blood (2021)
Propensity Score Matching Analysis Comparing Extracorporeal Photopheresis (ECP) Vs Best Available Therapy in Third Line or Later Treatment of Chronic Graft-Versus-Host Disease (cGVHD)
Authors: Swe Mar Linn, Igor Novitzky-Basso, Elizabeth Shin, Christopher J. Patriquin, Ivan Pasic, Wilson Lam, Arjun Law, Fotios Michelis, Armin Gerbitz, Auro Viswabandya, Jeffrey H. Lipton, Rajat Kumar, Jonas Mattsson, David Barth, Dennis Dong Hwan Kim
Journal: Blood (2021)
Abstract 9533: ‘Youthful’ Phenotype of C-kit+ Cardiac Fibroblasts
Authors: Fareheh Firouzi, Oscar H Echeagaray, Carolina Y Esquer, Natalie A Gude, Mark A Sussman
Journal: Circulation (2021)

Introduction: Fibroblasts are critical contributors to myocardial development, tissue homeostasis and remodeling. Cardiac fibroblast population heterogeneity and plasticity present a challenge for categorization of biological and functional properties. Distinct molecular markers and associated signaling pathways provide valuable insight for cardiac fibroblast biology and interventional strategies to influence injury response and remodeling. Receptor tyrosine kinase c-Kit mediates cell survival, proliferation, migration, and is activated by pathological injury. However, the biological significance of c-Kit within cardiac fibroblast population has not been addressed. Approach: An inducible c-Kit reporter mouse detects promoter activation with Green Fluorescent Protein (GFP) expression in cardiac interstitial cells (CICs). Coincidence of GFP and c-Kit with the DDR2 fibroblast marker was confirmed at protein level using flow cytometry and immunohistochemistry. Subsequently, cardiac fibroblasts expressing DDR2 with or without c-Kit were isolated and characterized in vitro . Results: A subset of DDR2 + cardiac fibroblasts also express c-Kit with coincidence in ~8% of total CICs. Pathological injury induces coincidence as well as expression of c-Kit and DDR2. Cultured cardiac DDR2+ fibroblasts that are c-Kit+ exhibit youthful morphological and functional phenotypes compared to c-Kit- cells including 1) significantly smaller size, 2) higher cellular motility, 3) enhanced proliferation, 4) less multinucleation, 5) decreased senescence-associated β-galactosidase staining, and 6) down-regulation of p53 senescence marker. Mechanistically, c-Kit expression correlates with signaling implicated in proliferation and cell migration including phospho-ERK and pro-Caspase 3. Conclusion: The phenotype of c-kit+ on DDR2+ cardiac fibroblasts correlates with multiple characteristics of ‘youthful’ cells. To our knowledge, this represents the first evaluation of c-Kit biology within DDR2+ cardiac fibroblast population and provides a fundamental basis for future studies to influence myocardial biology, cardiac remodeling, and response to pathological injury.
Real-time instance segmentation of surgical instruments using attention and multi-scale feature fusion
Authors: Juan Carlos Ángeles Cerón, Gilberto Ochoa Ruiz, Leonardo Chang, Sharib Ali
Journal: Medical Image Analysis (2022)

Precise instrument segmentation aids surgeons to navigate the body more easily and increases patient safety. While accurate tracking of surgical instruments in real-time plays a crucial role in minimally invasive computer-assisted surgeries, it is a challenging task to achieve, mainly due to: (1) a complex surgical environment, and (2) model design trade-off in terms of both optimal accuracy and speed. Deep learning gives us the opportunity to learn complex environment from large surgery scene environments and placements of these instruments in real world scenarios. The Robust Medical Instrument Segmentation 2019 challenge (ROBUST-MIS) provides more than 10,000 frames with surgical tools in different clinical settings. In this paper, we propose a light-weight single stage instance segmentation model complemented with a convolutional block attention module for achieving both faster and accurate inference. We further improve accuracy through data augmentation and optimal anchor localization strategies. To our knowledge, this is the first work that explicitly focuses on both real-time performance and improved accuracy. Our approach out-performed top team performances in the most recent edition of ROBUST-MIS challenge with over 44% improvement on area-based multi-instance dice metric MI_DSC and 39% on distance-based multi-instance normalized surface dice MI_NSD. We also demonstrate real-time performance (>60 frames-per-second) with different but competitive variants of our final approach.
The Balanced Biology of the Teaching Hospital
Authors: John H. Knowles
Journal: New England Journal of Medicine (1963)

The AdministratorSomewhere in the midst of doctor, patient and nurse stands the administrator, whose job it is to set the stage and implement all the activities of the teaching hospital. The name administrator has become less of a dirty word in hospitals in recent times as specialization has made administrators of everyone. The paradoxical arrangements of physician authority and administrator responsibility still remain, however — a situation that has fascinated the medical sociologist. The informal hierarchical structure of such a complex institution along with the responsibility of the administrator unmatched by commensurate authority makes the "outsider" wonder "how anything . . .
Rational Chemical and Genetic Modifications Enhance Avidity and Function of CD70-Directed CAR-T-Cells for Myeloid Leukemia
Authors: Mark B. Leick, Harrison Silva, Irene Scarfò, Rebecca Larson, Bryan D. Choi, Amanda A Bouffard, Kathleen M.E. Gallagher, Andrea Schmidts, Stefanie R. Bailey, Michael C. Kann, Max Jan, Marc Wehrli, Korneel Grauwet, Matthew J. Frigault, Marcela V. Maus
Journal: Blood (2021)
Factors influencing severe <scp>COVID</scp>‐19 in systemic vasculitis patients: comment on the article by Rutherford et al
Authors: Rıza Can Kardaş, Hamit Küçük
Journal: Arthritis & Rheumatology (2021)

Disclosure Form Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
NHS lacks the fundamental tools required to tackle discrimination, report warns
Authors: Matt Limb
Journal: BMJ (2021)

Inequality between NHS staff groups is persisting or getting worse, with a rise in reported discrimination across race, gender, disability status, and religion, research has found.

The analysis1 by the Nuffield Trust, published on 8 November, found that the 

pandemic had disproportionately affected some staff such as those from minority ethnic backgrounds. But it said the NHS lacks the tools to fully understand or tackle deep disparities which are bad for patient care, workforce retention, and recruitment.

It reported that discrimination and other forms of unfair treatment are “evident at every stage of the career pipeline,” despite efforts over years to identify and eradicate them.

Ethnic groups are being “lumped together” as a category when more nuanced data and analysis are needed to recognise how many different specific groups can be subject to exclusion, it added.

The report, commissioned by NHS Employers, …
Abdominal Surgery
Authors: Claude E. Welch, Ronald A. Malt
Journal: New England Journal of Medicine (1983)

PancreasAcute PancreatitisThe pancreas is an unparalleled concentration of digestive and synthetic enzymes tenuously surrounded by cell membranes. When the cell barrier is broken in the course of acute pancreatitis, the ideal therapy would inhibit enzymic activity, wash away debris, prevent associated pulmonary problems, and support the integrity of the systemic circulation. Neither as a result of any one treatment nor as a result of a combination of treatments is such rational therapy at hand.Peritoneal dialysis for early severe pancreatitis is at the moment the best means, though usually a weak one, of fulfilling many of the therapeutic . . .
Five-Year Follow-up of Keynote-087: Pembrolizumab Monotherapy in Relapsed/Refractory Classical Hodgkin Lymphoma (R/R cHL)
Authors: Philippe Armand, Pier Luigi Luigi Zinzani, Hun Ju Lee, Nathalie Johnson, Pauline Brice, John Radford, Vincent Ribrag, Daniel Molin, Theodoros P. Vassilakopoulos, Akihiro Tomita, Bastian von Tresckow, Margaret A. Shipp, Alex F. Herrera, Jianxin Lin, Eunhee Kim, Samhita Chakraborty, Patricia Marinello, Craig H. Moskowitz
Journal: Blood (2021)