tbuckley/cabot-search huggingface dataset:
Ebola RNA Persistence in Semen of Ebola Virus Disease Survivors — Final Report
Authors: Gibrilla F. Deen, Nathalie Broutet, Wenbo Xu, Barbara Knust, Foday R. Sesay, Suzanna L.R. McDonald, Elizabeth Ervin, Jaclyn E. Marrinan, Philippe Gaillard, Ndema Habib, Hongtu Liu, William Liu, Anna E. Thorson, Francis Yamba, Thomas A. Massaquoi, Faustin James, Archchun Ariyarajah, Christine Ross, Kyle Bernstein, Antoine Coursier, John Klena, Marylin Carino, Alie H. Wurie, Yong Zhang, Marion S. Dumbuya, Neetu Abad, Baimba Idriss, Teodora Wi, Sarah D. Bennett, Tina Davies, Faiqa K. Ebrahim, Elissa Meites, Dhamari Naidoo, Samuel J. Smith, Patricia Ongpin, Tasneem Malik, Anshu Banerjee, Bobbie R. Erickson, Yongjian Liu, Yang Liu, Ke Xu, Aaron Brault, Kara N. Durski, Jörn Winter, Tara Sealy, Stuart T. Nichol, Margaret Lamunu, James Bangura, Sihem Landoulsi, Amara Jambai, Oliver Morgan, Guizhen Wu, Mifang Liang, Qiudong Su, Yu Lan, Yanzhe Hao, Pierre Formenty, Ute Ströher, Foday Sahr
Journal: New England Journal of Medicine (2015)

Ebola virus has been detected in the semen of men after their recovery from Ebola virus disease (EVD). We report the presence of Ebola virus RNA in semen in a cohort of survivors of EVD in Sierra Leone.We enrolled a convenience sample of 220 adult male survivors of EVD in Sierra Leone, at various times after discharge from an Ebola treatment unit (ETU), in two phases (100 participants were in phase 1, and 120 in phase 2). Semen specimens obtained at baseline were tested by means of a quantitative reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay with the use of the target sequences of NP and VP40 (in phase 1) or NP and GP (in phase 2). This study did not evaluate directly the risk of sexual transmission of EVD.Of 210 participants who provided an initial semen specimen for analysis, 57 (27%) had positive results on quantitative RT-PCR. Ebola virus RNA was detected in the semen of all 7 men with a specimen obtained within 3 months after ETU discharge, in 26 of 42 (62%) with a specimen obtained at 4 to 6 months, in 15 of 60 (25%) with a specimen obtained at 7 to 9 months, in 4 of 26 (15%) with a specimen obtained at 10 to 12 months, in 4 of 38 (11%) with a specimen obtained at 13 to 15 months, in 1 of 25 (4%) with a specimen obtained at 16 to 18 months, and in no men with a specimen obtained at 19 months or later. Among the 46 participants with a positive result in phase 1, the median baseline cycle-threshold values (higher values indicate lower RNA values) for the NP and VP40 targets were lower within 3 months after ETU discharge (32.4 and 31.3, respectively; in 7 men) than at 4 to 6 months (34.3 and 33.1; in 25), at 7 to 9 months (37.4 and 36.6; in 13), and at 10 to 12 months (37.7 and 36.9; in 1). In phase 2, a total of 11 participants had positive results for NP and GP targets (samples obtained at 4.1 to 15.7 months after ETU discharge); cycle-threshold values ranged from 32.7 to 38.0 for NP and from 31.1 to 37.7 for GP.These data showed the long-term presence of Ebola virus RNA in semen and declining persistence with increasing time after ETU discharge. (Funded by the World Health Organization and others.).
Development of a ligand for in vivo imaging of mutant huntingtin in Huntington’s disease
Authors: Daniele Bertoglio, Jonathan Bard, Manuela Hessmann, Longbin Liu, Annette Gärtner, Stef De Lombaerde, Britta Huscher, Franziska Zajicek, Alan Miranda, Finn Peters, Frank Herrmann, Sabine Schaertl, Tamara Vasilkovska, Christopher J. Brown, Peter D. Johnson, Michael E. Prime, Matthew R. Mills, Annemie Van der Linden, Ladislav Mrzljak, Vinod Khetarpal, Yuchuan Wang, Deanna M. Marchionini, Mette Skinbjerg, Jeroen Verhaeghe, Celia Dominguez, Steven Staelens, Ignacio Munoz-Sanjuan
Journal: Science Translational Medicine (2022)

Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in the huntingtin ( HTT ) gene that encodes the pathologic mutant HTT (mHTT) protein with an expanded polyglutamine (polyQ) tract. Whereas several therapeutic programs targeting mHTT expression have advanced to clinical evaluation, methods to visualize mHTT protein species in the living brain are lacking. Here, we demonstrate the development and characterization of a positron emission tomography (PET) imaging radioligand with high affinity and selectivity for mHTT aggregates. This small molecule radiolabeled with 11 C ([ 11 C]CHDI-180R) allowed noninvasive monitoring of mHTT pathology in the brain and could track region- and time-dependent suppression of mHTT in response to therapeutic interventions targeting mHTT expression in a rodent model. We further showed that in these animals, therapeutic agents that lowered mHTT in the striatum had a functional restorative effect that could be measured by preservation of striatal imaging markers, enabling a translational path to assess the functional effect of mHTT lowering.
Renal Aging: Causes and Consequences
Authors: Eoin D. O’Sullivan, Jeremy Hughes, David A. Ferenbach
Journal: Journal of the American Society of Nephrology (2016)

Individuals age >65 years old are the fastest expanding population demographic throughout the developed world. Consequently, more aged patients than before are receiving diagnoses of impaired renal function and nephrosclerosis-age-associated histologic changes in the kidneys. Recent studies have shown that the aged kidney undergoes a range of structural changes and has altered transcriptomic, hemodynamic, and physiologic behavior at rest and in response to renal insults. These changes impair the ability of the kidney to withstand and recover from injury, contributing to the high susceptibility of the aged population to AKI and their increased propensity to develop subsequent progressive CKD. In this review, we examine these features of the aged kidney and explore the various validated and putative pathways contributing to the changes observed with aging in both experimental animal models and humans. We also discuss the potential for additional study to increase understanding of the aged kidney and lead to novel therapeutic strategies.
Report: health care reform must affirm 'right'
Authors: C. Marwick
Journal: JAMA (1993)

DISCUSSIONS about health care reform in the United States have, so far, been based mainly on economics and technical considerations of organization and control. How much will it cost? What should be covered? How will it be administered? And, above all, what are acceptable measures to contain costs? This is much too narrow a view of the vital issue, holds a newly released report from the American Association for the Advancement of Science (AAAS), the Washington, DC—based group that is the world's largest federation of scientific and engineering societies. One of the stated goals of the AAAS is "to improve the effectiveness of science in the promotion of human welfare." Its new report from the "Right to Health Care" project maintains that "there is a right to a basic and adequate standard of health care consistent with society's level of resources." If this right is to be meaningful, the report
Islet amyloid polypeptide cross-seeds tau and drives the neurofibrillary pathology in Alzheimer’s disease
Authors: Guoxin Zhang, Lanxia Meng, Zhihao Wang, Qinyu Peng, Guiqin Chen, Jing Xiong, Zhentao Zhang
Journal: Molecular Neurodegeneration (2022)

Abstract Background The pathologic accumulation and aggregation of tau is a hallmark of tauopathies including Alzheimer’s disease (AD). However, the molecular mechanisms mediating tau aggregation in AD remain elusive. The incidence of AD is increased in patients with type 2 diabetes (T2DM), which is characterized by the amyloid deposition of islet amyloid polypeptide (IAPP) in the pancreas. However, the molecular mechanisms bridging AD and T2DM remain unknown. Methods We first examined the presence of IAPP in the neurofibrillary tangles of AD patients. Then we tested the effect of IAPP on tau aggregation. The biochemical and biological characteristics of the IAPP-tau fibrils were tested in vitro. The seeding activity and neurotoxicity of the IAPP-tau fibrils were confirmed in cultured neurons. Lastly, the effect of IAPP on tau pathology and cognitive impairments was determined by injecting the IAPP-tau fibrils and IAPP fibrils into the hippocampus of tau P301S mice. Results We found that IAPP interacts with tau and accelerates the formation of a more toxic strain, which shows distinct morphology with enhanced seeding activity and neurotoxicity in vitro. Intrahippocampal injection of the IAPP-tau strain into the tau P301S transgenic mice substantially promoted the spreading of tau pathology and induced more severe synapse loss and cognitive deficits, when compared with tau fibrils. Furthermore, intracerebral injection of synthetic IAPP fibrils initiated tauopathy in the brain of tau P301S transgenic mice. Conclusions These observations indicate that IAPP acts as a crucial mediator of tau pathology in AD, and provide a mechanistic explanation for the higher risk of AD in individuals with T2DM.
Zac1 and the Imprinted Gene Network program juvenile NAFLD in response to maternal metabolic syndrome
Authors: Marine Baptissart, Christine M. Bradish, Brie S. Jones, Evan Walsh, Jesse Tehrani, Vicmarie Marrero‐Colon, Sanya Mehta, Dereje D. Jima, Seh Hoon Oh, Anna Mae Diehl, Tiffany Fougeray, Hervé Guillou, Michael Cowley
Journal: Hepatology (2022)

Abstract Background and Aims Within the next decade, NAFLD is predicted to become the most prevalent cause of childhood liver failure in developed countries. Predisposition to juvenile NAFLD can be programmed during early life in response to maternal metabolic syndrome (MetS), but the underlying mechanisms are poorly understood. We hypothesized that imprinted genes, defined by expression from a single parental allele, play a key role in maternal MetS‐induced NAFLD, due to their susceptibility to environmental stressors and their functions in liver homeostasis. We aimed to test this hypothesis and determine the critical periods of susceptibility to maternal MetS. Approach and Results We established a mouse model to compare the effects of MetS during prenatal and postnatal development on NAFLD. Postnatal but not prenatal MetS exposure is associated with histological, biochemical, and molecular signatures of hepatic steatosis and fibrosis in juvenile mice. Using RNA sequencing, we show that the Imprinted Gene Network (IGN), including its regulator Zac1 , is up‐regulated and overrepresented among differentially expressed genes, consistent with a role in maternal MetS‐induced NAFLD. In support of this, activation of the IGN in cultured hepatoma cells by overexpressing Zac1 is sufficient to induce signatures of profibrogenic transformation. Using chromatin immunoprecipitation, we demonstrate that Zac1 binds the TGF‐β1 and COL6A2 promoters, forming a direct pathway between imprinted genes and well‐characterized pathophysiological mechanisms of NAFLD. Finally, we show that hepatocyte‐specific overexpression of Zac1 is sufficient to drive fibrosis in vivo. Conclusions Our findings identify a pathway linking maternal MetS exposure during postnatal development to the programming of juvenile NAFLD, and provide support for the hypothesis that imprinted genes play a central role in metabolic disease programming.
Unique Epitope for a Natural Human IgE Monoclonal Antibody on Der p 2
Authors: Anna Pomes, Kriti Khatri, Crystal Richardson, Jill Glesner, Anyway Kapingidza, Lisa Vailes, Sabina Wuenschmann, Jian Zhang, R Stokes Peebles, Martin Chapman, Scott Smith, Maksymilian Chruszcz
Journal: Journal of Allergy and Clinical Immunology (2022)
Tracing PRX1+ cells during molar formation and periodontal ligament reconstruction
Authors: Xuyan Gong, Han Zhang, Xiaoqiao Xu, Yunpeng Ding, Xingbo Yang, Zhiyang Cheng, Dike Tao, Congjiao Hu, Yaozu Xiang, Yao Sun
Journal: International Journal of Oral Science (2022)

Abstract Neural crest-derived mesenchymal stem cells (MSCs) are known to play an essential function during tooth and skeletal development. PRX1 + cells constitute an important MSC subtype that is implicated in osteogenesis. However, their potential function in tooth development and regeneration remains elusive. In the present study, we first assessed the cell fate of PRX1 + cells during molar development and periodontal ligament (PDL) formation in mice. Furthermore, single-cell RNA sequencing analysis was performed to study the distribution of PRX1 + cells in PDL cells. The behavior of PRX1 + cells during PDL reconstruction was investigated using an allogeneic transplanted tooth model. Although PRX1 + cells are spatial specific and can differentiate into almost all types of mesenchymal cells in first molars, their distribution in third molars is highly limited. The PDL formation is associated with a high number of PRX1 + cells; during transplanted teeth PDL reconstruction, PRX1 + cells from the recipient alveolar bone participate in angiogenesis as pericytes. Overall, PRX1 + cells are a key subtype of dental MSCs involved in the formation of mouse molar and PDL and participate in angiogenesis as pericytes during PDL reconstruction after tooth transplantation.
Electroconvulsive Therapy
Authors: John P. Callan
Journal: JAMA (1979)

A shock seen round the world, the electricity stiffening MacMurphy's body in<i>One Flew Over the Cuckoo's Nest</i>, did little for psychiatry and less for electroconvulsive therapy (ECT). For many it was as close as they wanted to come to a therapy that is poorly understood and much maligned; yet, when properly used, it is dramatically effective in the treatment of psychosis. Theatergoers experienced a surge of revulsion as the procedure evoked images of judicial executions, medieval sorcery, inhumane punishment, and accidental electrocution. The lay public is not alone in its feelings, since many psychiatrists share these sentiments. A recent publication by the American Psychiatric Association,<sup>1</sup>reviewing the published literature since the early 1940s, indicates that one third of psychiatrists are generally opposed to the modality, and a survey<sup>2</sup>of California psychiatrists shows that less than 10% of them administer ECT. This trend away from ECT, a therapy
Mutations of the Angiotensinogen Gene and the Risk for Heart Disease and Stroke
Journal: Annals of Internal Medicine (2001)

Summaries for Patients15 May 2001Mutations of the Angiotensinogen Gene and the Risk for Heart Disease and StrokeSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-10-200105150-00004 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Blockages in the blood vessels to the heart (coronary arteries) can limit blood flow, causing what is known as ischemic heart disease. Temporary limitation of blood flow can cause chest pain (angina). If low blood flow lasts long enough, a section of heart tissue dies (a condition known as myocardial infarction, or “heart attack”). Ischemic cerebrovascular disease occurs when blockages develop in the blood vessels to the brain. Temporary blockage of blood flow to the brain is called a transient ischemic attack. If lack of blood lasts long ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Angiotensinogen Mutations and Risk for Ischemic Heart Disease, Myocardial Infarction, and Ischemic Cerebrovascular Disease. Six Case–Control Studies from the Copenhagen City Heart Study.” It is in the 15 May 2001 issue of Annals of Internal Medicine (volume 134, pages 941-954). The authors are AA Sethi, A Tybjærg-Hansen, MLM Grønholdt, R Steffensen, P Schnohr, and BG Nordestgaard.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAngiotensinogen Mutations and Risk for Ischemic Heart Disease, Myocardial Infarction, and Ischemic Cerebrovascular Disease: Six Case–Control Studies from the Copenhagen City Heart Study Amar A. Sethi , Anne Tybjærg-Hansen , Marie-Louise Moes Grønholdt , Rolf Steffensen , Peter Schnohr , and Børge G. Nordestgaard Metrics 15 May 2001Volume 134, Issue 10Page: I-5KeywordsBlood flowBlood vesselsBrainCardiovascular therapyCerebrovascular diseasesLongitudinal studiesMutationMyocardial infarctionPrimary hypertensionStroke ePublished: 15 May 2001 Issue Published: 15 May 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Distribution Patterns of Mite Allergens Among Children With Moderate-to-Severe T2 Asthma Endotype
Authors: Ruperto Gonzalez Perez, Paloma Poza Guedes, Fernando Pineda de la Losa, Miriam Castillo FernÃ¡ndez, Martina Aumayr, Elena Mederos Luis, Cristina Alava, Peter Forstenlechner, Victor Matheu, Inmaculada Sanchez-Machin
Journal: Journal of Allergy and Clinical Immunology (2022)
The Principles and Practice of Beauty Culture
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Granulomatosis With Polyangiitis
Authors: Joanna C. Robson, Peter C. Grayson, Cristina Ponte, Ravi Suppiah, Anthea Craven, Andrew Judge, Sara Khalid, Andrew Hutchings, Richard A. Watts, Peter A. Merkel, Raashid A. Luqmani
Journal: Arthritis & Rheumatology (2022)

To develop and validate revised classification criteria for granulomatosis with polyangiitis (GPA).
Clinicopathological conference. A case of hypoaldosteronism.
Journal: BMJ (1975)

Mrs. A. B. is now a 60-year-old housewife.For 27 years she had been troubled by a painful right wrist attributed to arthritis.In February 1969 she was admitted to hospital because of epigastric pain and vomiting and was told she had a peptic ulcer.While she was in hospital her feet began to swell and she developed an irregular pulse, her serum PBI concentration was found to be raised, hyperthyroidism was diagnosed, and she was treated with carbimazole, digoxin, diuretics, and a potassium supplement.In 1970, while still taking all these pills, she was admitted to hospital because of three episodes of profound muscular weakness and suffered a cardiac arrest shortly after admission; hyperkalaemia was found.No abnormal pigmentation was noted.She was successfully resuscitated and left hospital well.In 1971 she experienced some dyspeptic symptoms followed by melaena and was again admitted to hospital and treated with "white medicine."In 1972, though she was taking carbimazole (in addition to digoxin, frusemide, and potassium chloride), her hyperthyroidism was thought to be uncontrolled and she was given 181I therapy.Thereafter she stopped her carbimazole.The diuretic and potassium supplements were now being taken very infrequently, only when she felt her feet were swelling a little.In 1973 she was again admitted to hospital
The Importance of Using the Appropriate Model for Systematic Reviews and Meta-analyses
Authors: Jorge Sanz-Sánchez, Eugene McFadden, Hector M. Garcia-Garcia
Journal: JAMA Internal Medicine (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
CD4+ and CD8+CD60+ T cells in PBMC of IgE+ allergic adults express IL-4 or IFN alpha but not IFN gamma, and some express receptors for complement split products (CSP) C3a and C5a
Authors: Judah Gray, Matthew Chung, Seto Chice, Tamar Smith Norowitz, Maja Nowakowski, Helen Durkin
Journal: Journal of Allergy and Clinical Immunology (2022)
Safety and virologic impact of the IL-15 superagonist N-803 in people living with HIV: a phase 1 trial
Authors: Jeffrey S. Miller, Zachary B. Davis, Erika Helgeson, Cavan Reilly, Ann Thorkelson, Jodi Anderson, Noemia S. Lima, Siri Jorstad, Geoffrey T. Hart, John H. Lee, Jeffrey T. Safrit, Hing Wong, Sarah Cooley, Lavina Gharu, Hyunsoo Chung, Patrick Soon-Shiong, Curtis Dobrowolski, Courtney V. Fletcher, Jonathan Karn, Daniel C. Douek, Timothy W. Schacker
Journal: Nature Medicine (2022)
The relationship between sleep disturbances and allergic rhinitis in Korean children and adolescents
Authors: Kyung Suk Lee, Dae Hyun Lim, Youn Ho Sheen, Sun Hee Choi, In Hwan Oh, Sung-Woo Cho, Doo Hee Han, Chae-Seo Rhee, Yeong-Ho Rha
Journal: Journal of Allergy and Clinical Immunology (2022)
The effects of different doses of inhaled bacteriophage therapy for Pseudomonas aeruginosa pulmonary infections in mice
Authors: Rachel Yoon Kyung Chang, Michael Y.T. Chow, Yuncheng Wang, Chengxi Liu, Qixuan Hong, Sandra Morales, Andrew J. McLachlan, Elizabeth Kutter, Jian Li, Hak-Kim Chan
Journal: Clinical Microbiology and Infection (2022)