tbuckley/cabot-search huggingface dataset:
HPV16 INDUCED LARGE VENTRAL AIN3 IN A 29 YEAR OLD YOUNG LADY. SUCCESSFUL REMOVAL BY ESD
Authors: J. Hochberger
Journal: Endoscopy (2022)

A 29 year old young woman was referred because of a AIN grade 3 (intramucosal carcinoma) reaching from the anus 10 cm into the ventral rectum in projection of the dorsal wall of the vagina. Interdisciplinary tumor board discussion favored an attempt of ESD as alternative to radio-chemo therapy. Surgery was discouraged because of a high risk of a definitive terminal colostoma and risk of injury of the vagina. Meticulous preparation of the lesion resulted in successful removal (AIN3;R0). Follow-up after 1 year is shown.
PRE-ENDOSCOPIC SARS-COV-2 SCREENING IN ASYMPTOMATIC PATIENTS DURING THE FIRST YEAR AFTER RESTARTING ENDOSCOPIC SCREENING: A RETROSPECTIVE STUDY IN A TERTIARY CENTER
Authors: M. Fortuny, L. Gutierrez-Rios, A. Calm, I. Marin, N. Caballero, J. Colan-Hernandez, H. Uchima, V. Moreno de Vega, E. Domenech, I. Iborra
Journal: Endoscopy (2022)

Aims To describe the results of pre-endoscopic screening with Sars-CoV-2 RT-PCR performed in asymptomatic patients scheduled for elective endoscopy in our center in the 2nd, 3rd and 4th epidemic surges.
THE EFFECTIVENESS AND TOLERABILITY OF VERY LOW VOLUME PREPARATION FOR COLONOSCOPY COMPARED TO STANDARD 2 L AND 4 L PEG-SOLUTIONS IN A REAL-LIFE SETTING
Authors: N. Nyhlin, O. Bednarska, P. Thelin Schmidt, G. Wurm Johansson, E. Toth, P. Lindfors
Journal: Endoscopy (2022)

Aims Adequate bowel cleansing is essential for a high-quality colonoscopy. Recently, a new 1 litre (1L) polyethylene glycol (PEG) plus ascorbate solution (ASC) has been introduced. Our aims were to assess the effectiveness and tolerability of this product compared to standard 2L PEG-ASC and 4L PEG solutions, in a real-life setting.
SAFETY AND EFFICACY OF DOUBLE EUS-BYPASS VERSUS SURGICAL HEPATICOJEJUNOSTOMY AND GASTROJEJUNOSTOMY
Authors: M. Bronswijk, J. Lauwereys, H. van Malenstein, W. Laleman, J. Jaekers, H. Topal, B. Topal, R. Kunda, S. Van der Merwe
Journal: Endoscopy (2022)

Aims Both gastric outlet obstruction (GOO) and biliary obstruction may occur simultaneously in individual patients. Small series have suggested that double EUS-bypass is feasible. Our aim was to compare same-session double EUS-bypass to open surgical hepaticojejunostomy and gastrojejunostomy.
84P Serum 25-hydroxyvitamin D and cancer-related fatigue: Associations and effects on health-related quality of life in breast cancer survivors during adjuvant endocrine therapy
Authors: B.M.M.R. Santos, Í.D. Custódio, F. Nunes, M. Lima, K. Carvalho, D. Santana, J. Chiaretto, P.L. Canto, B. Laird, C.E. Paiva, Y.C. Maia
Journal: Annals of Oncology (2022)
TAKE A GLIMPSE TO THE SMALL BOWEL: ASSESSING MUCOSAL HEALING IN CELIAC PATIENTS WITH CAPSULE ENDOSCOPY
Authors: L. Scaramella, B. Marinoni, A. Rimondi, G.E. Tontini, R. Penagini, R. Sidhu, D.S. Sanders, D. Leffler, S. Chetcuti Zammit, M. Vecchi, L. Elli
Journal: Endoscopy (2022)

Aims Capsule endoscopy (CE) is useful in the management of complicated Celiac Disease (CD). However, its use to monitor treated CD is unclear and small bowel mucosal healing (SBMH) in CD is not usually assessed. The aim of this study was to determine the SBMH of CD patients monitored with CE.
PREDICTIVE FACTORS OF REBLEEDING AFTER THE FIRST ENDOSCOPIC THERAPY OF ESOPHAGEAL VARICEAL HEMORRHAGE
Authors: K. Rais, O. El Mqaddem, E. Dedane, O. El Eulj, A. Zazour, G. Kharasse, Z. Ismaili, W. Khannoussi
Journal: Endoscopy (2022)

Aims Variceal rebleeding describes bleeding that occurs≥120 hours after the first hemorrhage provided that hemostasis was initially achieved. It is associated with a high rate of mortality.This study aims to determine the independent factors associated with recurrent variceal bleeding in cirrhotic patients.
COMBINED ENDOSCOPIC AND SURGICAL MANAGEMENT OF A RIGHT INTRAHEPATIC BILE DUCT INJURY DURING LAPAROSCOPIC CHOLECYSTECTOMY
Authors: P. Mayer, L. Héroin, F. Habersetzer, M. Vix, P. Pessaux, E. Felli, G. Mathis
Journal: Endoscopy (2022)

We report the case of a 70-year-old female who underwent laparoscopic cholecystectomy following cholecystitis. Intraoperative opacification of biliary tract showed a section of the right posterior bile duct. At the same time, an ERCP was performed. The guidewire was introduced inside the right posterior bile ducts laparoscopically. A 7 French-15 cm plastic biliary stent was then placed inside the right posterior bile ducts to act as a stent for the healing of the bile duct. The immediate stent placement could ease the healing but also the calibration of the injured bile duct and thus avoid the occurrence of biliary stenosis.
EFFICACY AND SAFETY OF THE ENDOSCOPIC SEPTOSTOMY OF ZENKER'S DIVERTICULUM WITH THE SB-KNIFE
Authors: A.J. del Pozo-García, J.C. Marín-Gabriel, S. Sáenz-López, L. Ballesteros, P. Hernán, F. Sánchez-Gómez
Journal: Endoscopy (2022)

Aims Management of Zenker's diverticulum (ZD) through open neck surgery to perform a cricopharyngeal myotomy ,and stapling through rigid endoscopes have been the standard treatments in past decades. Several endoscopic techniques have been developed. We present our experience of Zenker's diverticulotomy (ZS) using a ﬂexible endoscope and an SB-knifeTM (Sumitomo Bakelite Ltd., Japan), primaily designed for ESD.
Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin
Authors: Nicole Y. Tsai, Fei Wang, Kenichi Toma, Chen Yin, Jun Takatoh, Emily L. Pai, Kongyan Wu, Angela C. Matcham, Luping Yin, Eric J. Dang, Denise K. Marciano, John L. Rubenstein, Fan Wang, Erik M. Ullian, Xin Duan
Journal: Nature Neuroscience (2022)
A Cyborg Insect Reveals a Function of a Muscle in Free Flight
Authors: T. Thang Vo-Doan, V. Than Dung, Hirotaka Sato
Journal: Cyborg and Bionic Systems (2022)

While engineers put lots of effort, resources, and time in building insect scale micro aerial vehicles (MAVs) that fly like insects, insects themselves are the real masters of flight. What if we would use living insect as platform for MAV instead? Here, we reported a flight control via electrical stimulation of a flight muscle of an insect-computer hybrid robot, which is the interface of a mountable wireless backpack controller and a living beetle. The beetle uses indirect flight muscles to drive wing flapping and three major direct flight muscles (basalar, subalar and third axilliary (3Ax) muscles) to control the kinematics of the wings for flight maneuver. While turning control was already achieved by stimulating basalar and 3Ax muscles, electrical stimulation of subalar muscles resulted in braking and elevation control in flight. We also demonstrated around 20 degrees of contralateral yaw and roll by stimulating individual subalar muscle. Stimulating both subalar muscles lead to an increase of 20 degrees in pitch and decelerate the flight by 1.5 m/s2 as well as an induce an elevation of 2 m/s2.
129P Effect of intra-operative and post operative topical tranexamic acid on the duration and the volume of the intra-operative drain in patients undergoing axillary lymph node dissection for breast cancer: A randomized controlled trial
Authors: R.N.N.S. Irrinki, A. Pachimatla, S. Khare, I. Laroiya, G. Singh
Journal: Annals of Oncology (2022)
105P CDK4/6 inhibitors in hormone receptor-positive, HER2-negative, locally advanced breast cancer (LABC): Biological and clinical activity, and post-surgical approaches
Authors: S. Parola, V. Di Lauro, P. De Placido, V. Forestieri, G. Buono, C. von Arx, E. Pietroluongo, M. Pagliuca, D. Cianniello, R. Lauria, R. Caputo, G. Arpino, S. de Placido, M. Giuliano, M. De Laurentiis, C. De Angelis
Journal: Annals of Oncology (2022)
PREVALENCE AND RISK FACTORS FOR SESSILE SERRATED LESIONS: A PROSPECTIVE STUDY IN A COLORECTAL CANCER SCREENING POPULATION
Authors: M. Bustamante-Balén, C. Satorres, V. Lorenzo-Zúñiga, F. Giner, N. Alonso-Lázaro, M. García-Campos, C. Sánchez-Montes, P. López-Muñoz, L. Argüello, V. Pons-Beltrán
Journal: Endoscopy (2022)

Aims To determine the prevalence of SSL in a FIT-based CRC screening program and to assess possible risk factors related to SSL development in comparison to adenomas.
Recall of B cell memory depends on relative locations of prime and boost immunization
Authors: Masayuki Kuraoka, Chen-Hao Yeh, Goran Bajic, Ryutaro Kotaki, Shengli Song, Ian Windsor, Stephen C. Harrison, Garnett Kelsoe
Journal: Science Immunology (2022)

Immunization or microbial infection can establish long-term B cell memory not only systemically but also locally. Evidence has suggested that local B cell memory contributes to early local plasmacytic responses after secondary challenge. However, it is unclear whether locality of immunization plays any role in memory B cell participation in recall germinal centers (GCs), which is essential for updating their B cell antigen receptors (BCRs). Using single B cell culture and fate mapping, we have characterized BCR repertoires in recall GCs after boost immunizations at sites local or distal to the priming. Local boosts with homologous antigen recruit the progeny of primary GC B cells to recall GCs more efficiently than do distal boosts. Recall GCs elicited by local boosts contain significantly more B cells with elevated levels of immunoglobulin (Ig) mutation and higher avidity BCRs. This local preference is unaffected by blocking CD40:CD154 interaction to terminate active, GC responses. Local boosts with heterologous antigens elicit secondary GCs with B cell populations enriched for cross-reactivity to the prime and boost antigens; in contrast, cross-reactive GC B cells are rare after distal boosts. Our results suggest that local B cell memory is retained in the form of memory B cells, GC B cells, and GC phenotype B cells that are independent of organized GC structures and that these persistent "primed B cells" contribute to recall GC responses at local sites. Our findings indicate the importance of locality in humoral immunity and inform serial vaccination strategies for evolving viruses.
ENDOSCOPIC SLEEVE GASTROPLASTY IN OBESE PATIENTS NOT ELEGIBLE FOR ORGAN TRANSPLANTATION
Authors: M.V. Matteo, V. Bove, V. Pontecorvi, M. De Siena, G. Carlino, N. Antonini, C. Massari, G. Giannetti, G. Costamagna, I. Boskoski
Journal: Endoscopy (2022)

Aims Class II or class III obesity (BMI≥35 kg/m2) is a contraindication to liver and kidney transplant because of the negative impact on transplant outcomes. Endoscopic sleeve gastroplasty (ESG) is a transoral bariatric procedure that may represent a minimally invasive therapeutic chance for obese organ candidates who have an excessive risk for bariatric surgery (BS). In this case series, we evaluate the role ESG in improving transplant candidacy in two candidates for liver and kidney transplant with obesity.
ADVERSE EVENTS OF ENDOSCOPIC FULL-THICKNESS RESECTION: RESULTS FROM THE GERMAN AND DUTCH COLORECTAL EFTR REGISTRY
Authors: L.W. Zwager, J. Mueller, B. Stritzke, N.S. Montazeri, K. Caca, E. Dekker, P. Fockens, A. Schmidt, B.A. Bastiaansen
Journal: Endoscopy (2022)

Aims Endoscopic full-thickness resection (eFTR) is emerging as minimally invasive alternative to surgery for complex colorectal lesions. Previous eFTR reports demonstrated favorable safety, however large studies representing a generalizable estimation of adverse events (AEs) are lacking. Our aim was to provide further insight in AEs following colorectal eFTR.
Geographic Differences in Sex-Specific Chronic Obstructive Pulmonary Disease Mortality Rate Trends Among Adults Aged ≥25 Years — United States, 1999–2019
Authors: Susan A. Carlson, Anne G. Wheaton, Kathleen B. Watson, Yong Liu, Janet B. Croft, Kurt J. Greenlund
Journal: MMWR Morbidity and Mortality Weekly Report (2022)

Chronic obstructive pulmonary disease (COPD) accounts for the majority of deaths from chronic lower respiratory diseases, the fourth leading cause of death in the United States in 2019.* COPD mortality rates are decreasing overall. Although rates in men remain higher than those in women, declines have occurred among men but not women (1). To examine the geographic variation in sex-specific trends in age-adjusted COPD mortality rates among adults aged ≥25 years, CDC analyzed 1999-2019 death certificate data, by urban-rural status,† U.S. Census Bureau region,§ and state. Among women, no significant change in overall COPD mortality occurred during this period; however, rates increased significantly in small metropolitan (average annual percent change [AAPC] = 0.6%), micropolitan (1.2%), and noncore (1.9%) areas and in the Midwest (0.6%). Rates decreased significantly in large central (-0.9%) and fringe metropolitan (-0.4%) areas (and in the Northeast (-0.5%) and West (-1.2%). Among men, rates decreased significantly overall (-1.3%), in all urban-rural areas (range = -1.9% [large central metropolitan] to -0.4% [noncore]) and in all regions (range = -2.0% [West] to -0.9% [Midwest]). Strategies to improve the prevention, treatment, and management of COPD are needed, especially to address geographic differences and improve the trend in women, to reduce COPD deaths.
ENDOSCOPIC DRAINAGE IN PATIENTS WITH HILAR CHOLANGIOCARCINOMA BISMUTH IV
Authors: B. Aabdi, O. Elmqaddem, A. Zazour, W. Khannoussi, G. Kharrasse, M.Z. Ismaili
Journal: Endoscopy (2022)

Aims Evaluate the endoscopic drainage in patients with hilar cholangiocarcinoma (CCK) bismuth IV using metallic stents (MS) and plastic stents (PS) versus percutaneous approach.
USE OF MAGNETICALLY CONTROLLED CAPSULE ENDOSCOPY BY REMOTE-CONTROL DURING PANDEMIC
Authors: A. Finta, K. Helle, M. Szalai, L. Madacsy
Journal: Endoscopy (2022)

Aims To assess the effect of the virus on the digestive system by examining the upper gastrointestinal tract of patients with gastrointestinal symptoms after COVID-19 infection.
DETAILED METHOD TO DETERMINE CARBON FOOTPRINT
Authors: R. Martín-Cabezuelo, P. López-Muñoz, V. Pons-Beltrán, G. Vilariño, P.A. Betín, I. Tort, A. Vidaurre, V. Lorenzo-Zúñiga
Journal: Endoscopy (2022)

Due to COVID19 pandemic, the use of disposable materials for healthcare purposes has increase significantly, leading to a rampant increase of residues which affects the environment. Determining the life cycle of GI instruments is key factor in improvement our environmental footprint. For that each of the instruments are characterised by several techniques such as, Fourier transform infrared spectroscopy, Energy Dispersive X-Ray analysis, Differential Scanning Calorimetry, and Thermogravimetric Analysis. The establishment of GI instruments carbon footprint make the healthcare institutions become aware of its environmental effect and helps to reduce its detrimental effect by choosing the better option.
THE IMPACT OF SMARTPHONE APPLICATION ON THE QUALITY OF BOWEL PREPARATION FOR COLONOSCOPY IN VIETNAM
Authors: V.H. Dao, V.Q. Dao, N.H. Lam, L.V. Dao
Journal: Endoscopy (2022)

Aims The development and feasibility of smartphone apps in limited resources countries is not yet clear. This study is aimed to evaluate the impact of smartphone apps on the quality of bowel preparation compared to conventional protocol.
99P Cost effectiveness of pembrolizumab in combination with chemotherapy as neoadjuvant therapy and continued as a single agent as adjuvant therapy for high-risk early-stage TNBC in the United States
Authors: P.A. Fasching, M. Huang, A. Haiderali, W. Xue, W. Pan, Z-Y. Zhou, P. Hu, M. Chaudhuri, C. Le Bailly De Tilleghem, N. Cappoen, J. O'Shaughnessy
Journal: Annals of Oncology (2022)
49P Analysis of HER2-low carcinomas and PAM50 signature in an early-stage breast cancer cohort
Authors: R. Sanchez Bayona, P. Tolosa, M. Alba Bianchi, A. Madariaga Urrutia, S. Teran, M. Rey Cardenas, L. Lema Roso, Y. Ruano, L. Manso, E.M. Ciruelos
Journal: Annals of Oncology (2022)
Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis
Authors: Andrew D. Grotzinger, Travis T. Mallard, Wonuola A. Akingbuwa, Hill F. Ip, Mark J. Adams, Cathryn M. Lewis, Andrew M. McIntosh, Jakob Grove, Søren Dalsgaard, Klaus-Peter Lesch, Nora Strom, Sandra M. Meier, Manuel Mattheisen, Anders D. Børglum, Ole Mors, Gerome Breen, Manuel Mattheisen, Ole Mors, Sandra M. Meier, Phil H. Lee, Kenneth S. Kendler, Jordan W. Smoller, Elliot M. Tucker-Drob, Michel G. Nivard
Journal: Nature Genetics (2022)
165MO Trastuzumab-deruxtecan (T-DXd) in HER2-positive breast cancer patients (pts) with active brain metastases: Primary outcome analysis from the TUXEDO-1 trial
Authors: R. Bartsch, A.S. Berghoff, J. Furtner, M. Marhold, E.S. Bergen, S. Roider-Schur, A.M. Starzer, H. Forstner, B. Rottenmanner, K. Dieckmann, Z.A. Bago-Horvath, G. Widhalm, A. Ilhan-Mutlu, C. Minichsdorfer, T. Fuereder, C.F. Singer, A. Weltermann, R. Puhr, M. Preusser
Journal: Annals of Oncology (2022)
A bivalent Epstein-Barr virus vaccine induces neutralizing antibodies that block infection and confer immunity in humanized mice
Authors: Chih-Jen Wei, Wei Bu, Laura A. Nguyen, Joseph D. Batchelor, JungHyun Kim, Stefania Pittaluga, James R. Fuller, Hanh Nguyen, Te-Hui Chou, Jeffrey I. Cohen, Gary J. Nabel
Journal: Science Translational Medicine (2022)

Epstein-Barr virus (EBV) is the major cause of infectious mononucleosis and is associated with several human cancers and, more recently, multiple sclerosis. Despite its prevalence and health impact, there are currently no vaccines or treatments. Four viral glycoproteins (gp), gp350 and gH/gL/gp42, mediate entry into the major sites of viral replication, B cells, and epithelial cells. Here, we designed a nanoparticle vaccine displaying these proteins and showed that it elicits potent neutralizing antibodies that protect against infection in vivo. We designed single-chain gH/gL and gH/gL/gp42 proteins that were each fused to bacterial ferritin to form a self-assembling nanoparticle. Structural analysis revealed that single-chain gH/gL and gH/gL/gp42 adopted a similar conformation to the wild-type proteins, and the protein spikes were observed by electron microscopy. Single-chain gH/gL or gH/gL/gp42 nanoparticle vaccines were constructed to ensure product homogeneity needed for clinical development. These vaccines elicited neutralizing antibodies in mice, ferrets, and nonhuman primates that inhibited EBV entry into both B cells and epithelial cells. When mixed with a previously reported gp350 nanoparticle vaccine, gp350D 123 , no immune competition was observed. To confirm its efficacy in vivo, humanized mice were challenged with EBV after passive transfer of IgG from mice vaccinated with control, gH/gL/gp42+gp350D 123 , or gH/gL+gp350D 123 nanoparticles. Although all control animals were infected, only one mouse in each vaccine group that received immune IgG had detectable transient viremia. Furthermore, no EBV lymphomas were detected in immune animals. This bivalent EBV nanoparticle vaccine represents a promising candidate to prevent EBV infection and EBV-related malignancies in humans.
A SIMPLE CLINICAL RISK SCORE CAN PREDICT PROCEDURE-RELATED ADVERSE EVENTS IN ERCPS WITH TRAINEE INVOLVEMENT: RESULTS FROM THE INTERNATIONAL MULTICENTER OBSERVATIONAL TIERS STUDY
Authors: T.A. Voiosu, A. Bengus, M. Bronswijk, A. Voiosu, I. Boskoski, P. Balanescu, I. Klarin, B. Smarandache, I. Lyutakov, R.B. Mateescu, S. Wani
Journal: Endoscopy (2022)

Aims There are limited data assessing the impact of trainee involvement on ERCP effectiveness and safety. We aimed to validate a simple risk score ([Table 1]) that includes patient- and procedure-related variables designed to predict adverse events (AEs) in ERCPs with trainee involvement.
ENDOSCOPIC MANAGEMENT OF IATROGENIC PERFORATIONS DURING THERAPEUTIC ENDOSCOPY – KEEP CALM AND HAVE A PLAN B
Authors: J. Ferreira-Silva, E. Rodrigues-Pinto, G. Macedo
Journal: Endoscopy (2022)

We describe 2 patients with endoscopic perforations after stricture dilation and stent placement, caused by the advancement of the tip of the devices. The first case refers to a patient with a 6mm ileal pouch perforation caused by balloon tip advancement during dilation of an ileoanal anastomosis stricture, managed with endoscopic clips. The second case refers to a woman with an 8mm jejunal limb perforation caused by the advancement of the stent delivery system, used to treat a post-gastrectomy leak, that was managed with an OTSC and a second stent covering the leak and the perforation. Both patients remain well.
REMOVAL OF AN OVER-THE-SCOPE-CLIP USING THE OVESCO-REMOVAL DEVICE BEFORE POLYPECTOMY OF THE POLYP RECURRENCE
Authors: J. Pérez Pérez, F. Garrido Gallego, J.C. Villa Poza, Á. Ponferrada Díaz, Á. Martínez-Alcalá
Journal: Endoscopy (2022)

In November 2020, a 45 mm sessile polyp was found during a screening colonoscopy. The initial resection attempt was complicated by massive spurting–bleeding.
Colorectal Cancer Screening in the US—Still Putting the Cart Before the Horse?
Authors: Ricardo J. Bello, George J. Chang, Nader N. Massarweh
Journal: JAMA Oncology (2022)

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Systematic characterization of gene function in the photosynthetic alga Chlamydomonas reinhardtii
Authors: Friedrich Fauser, Josep Vilarrasa-Blasi, Masayuki Onishi, Silvia Ramundo, Weronika Patena, Matthew Millican, Jacqueline Osaki, Charlotte Philp, Matthew Nemeth, Patrice A. Salomé, Xiaobo Li, Setsuko Wakao, Rick G. Kim, Yuval Kaye, Arthur R. Grossman, Krishna K. Niyogi, Sabeeha S. Merchant, Sean R. Cutler, Peter Walter, José R. Dinneny, Martin C. Jonikas, Robert E. Jinkerson
Journal: Nature Genetics (2022)

Most genes in photosynthetic organisms remain functionally uncharacterized. Here, using a barcoded mutant library of the model eukaryotic alga Chlamydomonas reinhardtii, we determined the phenotypes of more than 58,000 mutants under more than 121 different environmental growth conditions and chemical treatments. A total of 59% of genes are represented by at least one mutant that showed a phenotype, providing clues to the functions of thousands of genes. Mutant phenotypic profiles place uncharacterized genes into functional pathways such as DNA repair, photosynthesis, the CO
DIAGNOSTIC YIELD OF ENDOSCOPY IN ASYMPTOMATIC PATIENTS WITH NON-IRON DEFICIENCY ANAEMIA
Authors: O. Pauliuc, M. Patel, S. Ali Afsal, K. Menon, F. Moothedath, R. Fasal, T. Rajab, A. Naing, S. Kumar, M.G. Shiha, T. Thomas
Journal: Endoscopy (2022)

Aims Endoscopic evaluation of the gastrointestinal (GI) tract is indicated for asymptomatic patients with iron deficiency anaemia (IDA) to rule out GI malignancy. However, there is a paucity of evidence for endoscopy in anaemic patients without iron deficiency (non-IDA). Our aim was to compare the diagnostic yield of endoscopy in asymptomatic patients with non-IDA compared to those with IDA.