tbuckley/cabot-search huggingface dataset:
THE CIRCULATORY COMPENSATION IN SEVERE ANEMIAS
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Numerosity, area-osity, object-osity? Oh my
Authors: Sami R. Yousif
Journal: Behavioral and Brain Sciences (2021)

Abstract There is ongoing debate about whether number is perceived directly. Clarke and Beck suggest that what plagues this debate is a lack of shared understanding about what it means to perceive number in the first place. I agree. I argue that the perception of number is held to a different standard than, say, the perception of objecthood; considering this, I explore what it might mean for the number system to represent rational numbers.
Alcoholic liver disease.
Authors: A D Thomson, G L Bird, J B Saunders
Journal: Gut (1991)

During the 1950s and '60s when the debate about the relative contribution of alcohol toxicity and malnutrition to alcohol related liver damage was raging in the United States,' Britain was more interested in other forms of liver disease.As awareness ofthe size of the alcohol problem grew in this country,23 research work at the Liver Unit began to reflect the changing situation.Immuno- logy was already well established at King's and the development of a new lymphocytotoxicity assay by Thomson and colleagues provided a useful tool for investigating immunological changes in alcoholic liver disease.4These studies have continued over the past 15 years with the aim of identifying the precise mechanisms involved and why some patients have a propensity to progressive liver damage, even when alcohol is discontinued.5These investigations naturally lead to attempts to identify groups of individuals especially sus- ceptible to alcohol induced liver injury.This was the main focus of research in the 'middle period' from the late 1970s onwards.Research into alcoholic liver disease expanded considerably in 1979 with the formation of a multidisciplinary Alcohol Research Group by Michael Davis and John Saunders.This group extended its work into biochemical mechanisms of liver damage in conjunction with the MRC Human Biochemical Genetics Unit.It also established a programme of research into the underlying alcohol dependency and psychosocial factors.The group, which was supported by the Department of Health and Social Security, forged close links with the Addiction Research Unit at the Maudsley Hos- pital.This resulted in a more comprehensive approach to management, including psycho- logical as well as medical treatment.6S97
Pulmonary Hypertension
Authors: David Poch, Jess Mandel
Journal: Annals of Internal Medicine (2021)

Pulmonary hypertension is the term used to describe a group of disorders characterized by abnormally high pressures in the pulmonary arteries. Initial evaluation is focused on identifying the cause, which helps guide appropriate treatment. Pulmonary hypertension is often a feature of advanced common diseases, such as chronic obstructive pulmonary disease and left heart disease, and treatment is focused primarily on the underlying disease. More rarely, pulmonary hypertension results from chronic organized thromboemboli or a primary vasculopathy. The former requires evaluation for surgical intervention, and the latter is treated with advanced medical therapies.
Education: a neglected social determinant of health
Authors: None The Lancet Public Health
Journal: The Lancet Public Health (2020)

Education and health and wellbeing are intrinsically linked. The evidence behind the importance of education as a determinant of health is amongst the most compelling. Education is strongly associated with life expectancy, morbidity, health behaviours, and educational attainment plays an important role in health by shaping opportunities, employment, and income. In this issue of The Lancet Public Health, two research Articles emphasise the lifelong impact of education on health. The study by Yu-Tzu Wu and colleagues shows that differences in education and wealth established earlier in life were strongly associated with disparities in healthy ageing across a large, multi country cohort of older people.
Importance of three-dimensional treatment planning and dose-volume histogram analysis in the performance and evaluation of intravascular brachytherapy Louis B. Harrison, Akiko Maehara, Neil S. Patel, Neil J. Weissman, Ron Waksman, Gary S. Mintz, Taya L. McMillan, Julianna Pisch, Harry Quon, Nathan Yang, Rosanna Chan, Huchen Xie, Sou-Tung Chiu-Tsao. Department of Radiation Oncology, Beth Israel Medical Center &amp; St. Luke's-Roosevelt Hospital Center, New York, NY, Cardiovascular Research …
Journal: Journal of the American College of Cardiology (2001)
Reply
Authors: Simon G. Duckett, Matthew R. Ginks, Anoop K. Shetty, Julian Bostock, Jaswinder S. Gill, Shoaib Hamid, Stam Kapetanakis, Eliane Cunliffe, Reza Razavi, Gerry Carr-White, C. Aldo Rinaldi
Journal: Journal of the American College of Cardiology (2012)
Abstract P106: Epigenetic Age Acceleration and Postprandial Lipemia in the Genetics of Lipid Lowering Drugs and Diet Network Study
Authors: Marguerite R Irvin, Bertha Hidalgo, Degui Zhi, Stella Aslibekyan, Hemant K Tiwari, Devin Absher, Donna K Arnett
Journal: Circulation (2017)

Background: Calculated ‘epigenetic age,’ a novel biomarker based on DNA methylation levels of 353 CpGs, has been demonstrated to accurately predict chronological age across a broad spectrum of tissues and cell types. Recently epigenetic age acceleration or older epigenetic age in comparison to chronological age has been robustly associated with all-cause mortality independent of chronological age in multiple human cohorts. However, accelerated epigenetic aging has not been associated with lipids levels, including postprandial lipid levels which are linked to prothrombotic and proinflammatory processes that may precipitate aging. In the current study we aimed to evaluate the association between epigenetic age acceleration and lipid levels. Methods: We used the Horvath DNA methylation age calculator to estimate epigenetic age in 988 Caucasian participants from the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) using Illumina Infinium HumanMethylation450 BeadChip array data derived from CD4+ T-cell DNA. GOLDN participants did not take lipid lowering drugs for at least four weeks prior to enrollment and underwent a standardized high fat meal challenge after fasting for at least 8 hours followed by timed blood draws at 3.5 and 6 hours following the meal. Epigenetic age acceleration was calculated as the residual from regressing methylation age on chronological age. We used linear mixed models to examine the association of age acceleration quartiles with fasting and postrandial (3.5 and 6 hour time points) low density lipoprotein (LDL), high density lipoprotein (HDL) and triglyceride (TG) levels after adjusting for age, study site, sex, fasting lipid level (if applicable), deconvolution estimated T-cell type percentages and a random effect of family relationship. Results: The correlation between calculated methylation age and chronological age was 0.91. The difference between methylation age and chronological age (methylation age - chronological age) was on average -5.8 (5.9), -0.5 (4.7), 2.9 (4.3), and 7.8 (5.0) years for the first through fourth quartiles of age acceleration, respectively. After adjustment for covariates neither fasting nor postprandial lipids were associated with age acceleration quartile. Conclusions: Evidence from the current study suggests lipid levels in the fasting and postprandial state are not related to accelerated epigenetic aging, however given the association between epigenetic age acceleration and mortality observed in previous studies the relationship of other metabolic parameters with age acceleration may be worthy of investigation.
Bedside Diagnostic Blood Testing
Authors: Michael Salem
Journal: JAMA (1991)

<h3>Objective.</h3> —Bedside diagnostic testing utilizing microchemistry instruments potentially offers physicians the opportunity to evaluate urgent blood test results rapidly and reliably using only drops (250 μL) of whole blood. The use of microchemistry technology may also represent an essential component of a blood conservation program in acutely ill patients. We tested the hypothesis that a microchemistry instrument would have important advantages in the intensive care unit, including rapid turnaround time, decreased iatrogenic blood loss, and the provision of accurate analyte results. <h3>Design.</h3> —One-year prospective, random-sample comparative study. <h3>Setting.</h3> —A tertiary, acute care, 1000-bed university teaching hospital and a 450-bed university-affiliated community hospital. <h3>Patients.</h3> —Blood samples from 850 patients were analyzed. <h3>Results.</h3> —There were strong correlations (for pH,<i>R</i><sup>2</sup>=.97; Pco<sub>2</sub>,<i>R</i><sup>2</sup>=.97; Po<sub>2</sub>,<i>R</i><sup>2</sup>=.99; sodium,<i>R</i><sup>2</sup>=.83; potassium,<i>R</i><sup>2</sup>=.94; chloride,<i>R</i><sup>2</sup>=.90; glucose,<i>R</i><sup>2</sup>=.98; and hematocrit,<i>R</i><sup>2</sup>=.92) when paired samples were analyzed simultaneously in the laboratory comparing the microchemistry instrument and currently accepted clinical laboratory instruments. There were significant correlations (for pH,<i>R</i><sup>2</sup>=.91; Pco<sub>2</sub>,<i>R</i><sup>2</sup>=.94; Po<sub>2</sub>,<i>R</i><sup>2</sup>=.97; sodium,<i>R</i><sup>2</sup>=.91; potassium,<i>R</i><sup>2</sup>=.86; chloride,<i>R</i><sup>2</sup>=.91; ionized calcium,<i>R</i><sup>2</sup>=.82; glucose,<i>R</i><sup>2</sup>=.96; and hematocrit,<i>R</i><sup>2</sup>=.75) but increased variability occurred in some analyte results when samples were first analyzed in the intensive care unit (using the microchemistry instrument) and then transported to the laboratory in the routine fashion for "stat" determinations. <h3>Conclusions.</h3> —The multichannel microchemistry instrument provided accurate analyte determinations when compared with accepted clinical laboratory instruments. Significant savings of time and blood were also realized by the use of a microchemistry instrument in the intensive care unit. Bedside microchemistry may provide clinically important advantages in emergency departments, operating rooms, and neonatal, pediatric, coronary, adult medical and surgical, trauma, and burn intensive care units. (<i>JAMA</i>. 1991;266:382-389)
Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles
Authors: Sarah A. Dick, Anthony Wong, Homaira Hamidzada, Sara Nejat, Robert Nechanitzky, Shabana Vohra, Brigitte Mueller, Rysa Zaman, Crystal Kantores, Laura Aronoff, Abdul Momen, Duygu Nechanitzky, Wanda Y. Li, Parameswaran Ramachandran, Sarah Q. Crome, Burkhard Becher, Myron I. Cybulsky, Filio Billia, Shaf Keshavjee, Seema Mital, Clint S. Robbins, Tak W. Mak, Slava Epelman
Journal: Science Immunology (2022)

Resident macrophages orchestrate homeostatic, inflammatory, and reparative activities. It is appreciated that different tissues instruct specialized macrophage functions. However, individual tissues contain heterogeneous subpopulations, and how these subpopulations are related is unclear. We asked whether common transcriptional and functional elements could reveal an underlying framework across tissues. Using single-cell RNA sequencing and random forest modeling, we observed that four genes could predict three macrophage subsets that were present in murine heart, liver, lung, kidney, and brain. Parabiotic and genetic fate mapping studies revealed that these core markers predicted three unique life cycles across 17 tissues. TLF+ (expressing TIMD4 and/or LYVE1 and/or FOLR2) macrophages were maintained through self-renewal with minimal monocyte input; CCR2+ (TIMD4−LYVE1−FOLR2−) macrophages were almost entirely replaced by monocytes, and MHC-IIhi macrophages (TIMD4−LYVE1−FOLR2−CCR2−), while receiving modest monocyte contribution, were not continually replaced. Rather, monocyte-derived macrophages contributed to the resident macrophage population until they reached a defined upper limit after which they did not outcompete pre-existing resident macrophages. Developmentally, TLF+ macrophages were first to emerge in the yolk sac and early fetal organs. Fate mapping studies in the mouse and human single-cell RNA sequencing indicated that TLF+ macrophages originated from both yolk sac and fetal monocyte precursors. Furthermore, TLF+ macrophages were the most transcriptionally conserved subset across mouse tissues and between mice and humans, despite organ- and species-specific transcriptional differences. Here, we define the existence of three murine macrophage subpopulations based on common life cycle properties and core gene signatures and provide a common starting point to understand tissue macrophage heterogeneity.
Early-stage structure-based drug discovery for small GTPases by NMR spectroscopy
Authors: Guowei Yin, Guohua Lv, Jerry Zhang, Hongmei Jiang, Tianqi Lai, Yushan Yang, Yong Ren, Jing Wang, Chenju Yi, Hao Chen, Yun Huang, Chaoni Xiao
Journal: Pharmacology & Therapeutics (2022)
Recombinant porphobilinogen deaminase targeted to the liver corrects enzymopenia in a mouse model of acute intermittent porphyria
Authors: Karol M. Córdoba, Irantzu Serrano-Mendioroz, Daniel Jericó, María Merino, Lei Jiang, Ana Sampedro, Manuel Alegre, Fernando Corrales, María J. Garrido, Paolo G. V. Martini, José Luis Lanciego, Jesús Prieto, Pedro Berraondo, Antonio Fontanellas
Journal: Science Translational Medicine (2022)

Systemic and subcutaneous rApoAI-PBGD therapy protects against porphyrin precursor accumulation, pain, and motor neuropathy in AIP mice.
The Case | An unusual cause of renal vascular thrombi after kidney transplantation
Authors: Pauline Erpicum, Stéphanie Grosch, Catherine Bonvoisin, Antoine Bouquegneau, Laurent Weekers, Luc Radermacher, François Jouret, Marie Lejeune, Olivier Hougrand, Christophe Bovy
Journal: Kidney International (2022)
Moving toward genome-editing therapies for cardiovascular diseases
Authors: Kiran Musunuru
Journal: Journal of Clinical Investigation (2022)

The rapid invention of genome-editing technologies over the past decade, which has already been transformative for biomedical research, has raised the tantalizing prospect of an entirely new therapeutic modality. Whereas the treatment of chronic cardiovascular diseases has heretofore entailed the use of chronic therapies that typically must be taken repeatedly and frequently for the remainder of the lifetime, genome editing will enable the development of "one-and-done" therapies with durable effects. This Review summarizes the variety of available genome-editing approaches, including nuclease editing, base editing, epigenome editing, and prime editing; illustrates how these various approaches could be implemented as novel therapies for cardiovascular diseases; and outlines a path from technology development to preclinical studies to clinical trials. Although this Review focuses on PCSK9 as an instructive example of the various genome-editing approaches under active investigation, the lessons learned will be broadly applicable to the treatment of a variety of diseases.
Can coronary flow reserve using transthoracic color doppler echo in the left anterior descending artery predict restenosis after PTCA? Usefulness of contrast enhanced diastolic coronary flow velocity Masako Okada, Takahiro Ota, Hiroyuki Okura, Keiji Nagae, Yukio Abe, Hirohito Yoh, Shiro Yanagi, Kazuyoshi Hirota, Hiroyuki Watanabe, Junichi Yoshikawa. Fuchu Hospital, Izumi city, Japan, Osaka City University Medical School, Osaka city, Japan
Journal: Journal of the American College of Cardiology (2001)
Cancer Medicine
Authors: Jacob Bitran
Journal: JAMA (1982)

The long-awaited second edition of<i>Cancer Medicine</i>by Holland and Frei has finally been published. The first edition, published in 1973, was the standard text for medical oncologists. Publication of an oncology text presents difficulties to the editors, for they must ensure that the "how to do and treat" aspects of oncology are clearly stated and reflect the state of the art. However, a strictly "how to" textbook would be inadequate, as it would omit a discussion of the biological principles that form the basis of oncology. Holland and Frei were well aware of the need for stating the principles in their first edition, and this second edition of<i>Cancer Medicine</i>, like the first, provides the reader with the basic principles of neoplasia: its etiology (124 pages); pathogenesis (76 pages); epidemiology (72 pages); and the basis of its treatment—surgery, radiotherapy, and chemotherapy (190 pages). Thus, in this text there is
Questions and Answers
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A brief smartphone-based intervention significantly improved pre-exposure prophylaxis adherence among Chinese men sex with men: Findings of a randomized controlled trial
Authors: Zhaozhen Liu, Rantong Bao, Xiangjun Zhang, Hongyi Wang, Zixin Wang, Jing Zhang, Zhenxing Chu, Qinghai Hu, Hanzhu Qian, Weiming Tang, Zhili Hu, Shangcao Li, Hang Li, Haibo Ding, Wenqing Geng, Yongjun Jiang, Hong Shang, Junjie Xu
Journal: Journal of Infection (2022)
OPIUM-EATING
Authors: J. B. Harrison
Journal: BMJ (1856)

be the few words of the latter author: "The sediment de- poited by acute serous urine, is usually of a deep brownish red colour; and consists essentially of the lithate of am- monia" (p. 122).But this is followed by: "In all in- stances, on the application of heat (about 150°or 1600), acute serous urine becomes opaque, from the deposition of alb ous matter."Now this latter observation does not at al apply to the deposit in question.The deposit appears generally in the convalescent stage of the disease, or, at least, after the disappearance of the eruption, and is generally, but not always, associated with dropsy; but I have seen it in all stages.I have seen it accompany the eruption: I have also seen it without any eruption-in fact, as the only symptom of this erratic ma- lady; of this, more anon.Generally persistent through some days, or even two or three weeks, it is occasionally
British Heart Journal, London
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Time of in-hospital death in patients with acute myocardial infarction treated with primary angioplasty compared to patients treated with intravenous thrombolysis. Results from the pooled data of the MITRA and the MIR registries Ralf Zahn, Steffen Schneider, Rudolf Schiele, Anselm K. Gitt, Harm Wienbergen, Claus Bossaller, Martin Gottwik, Jochen Senges. Heart center, Ludwigshafen, Germany
Journal: Journal of the American College of Cardiology (2001)