tbuckley/cabot-search huggingface dataset:
ADENOMA DETECTION RATE AND RISK OF INTERVAL POST-COLONOSCOPY COLORECTAL CANCER IN FIT-BASED SCREENING
Authors: P. Wisse, N. Erler, S. de Boer, B. den Hartog, M. Oudkerk Pool, J. Terhaar sive Drose, C. Verveer, G. Meijer, I. Lansdorp-Vogelaar, E. Kuipers, E. Dekker, M. Spaander
Journal: Endoscopy (2022)

Aims Adenoma detection rate (ADR) is an essential quality indicator for endoscopists performing colonoscopies for colorectal cancer screening as it is associated with post-colonoscopy colorectal cancers (PCCRCs). Currently, data on ADRs of endoscopists performing colonoscopies in fecal immunochemical testing (FIT)-based screening, the most common screening method, is scarce. Also, the association between ADR and PCCRC has not been demonstrated in this setting. Patients and endoscopists may benefit from an ADR target that minimizes PCCRC risk and represent adequate colonoscopy performance after positive FIT.
4P Longitudinal proteogenomic profiling reveals therapeutic vulnerabilities of immunometabolism in breast cancer
Authors: K. Wang, I. Zerdes, E.G. Sifakis, H.J. Johansson, A. Mezheyeuski, J. Lehtiö, J. Bergh, T. Hatschek, A. Matikas, T. Foukakis
Journal: Annals of Oncology (2022)
82P Clinical application of a genomic tool for decision support in breast cancer patients in Scotland
Authors: A.L. Peters, B. Elseberger, P. Hall, L.B. Jordan, F.Y. Soh, G.N. Urquhart, L. Hannington, D. Cartwright, S. Makaranka, M. Vallet, H. Marashi
Journal: Annals of Oncology (2022)
57TiP SOLTI-1910: Predicting olaparib sensitivity in patients with unresectable locally advanced/metastatic HER2-negative breast cancer with BRCA1/2, PALB2, RAD51C/D mutations or HRD by the RAD51 test: RADIOLA trial
Authors: J. Balmana, T. Pascual, A. Llop-Guevara, P. Tolosa, I. Blancas López-Barajas, M.E. Perez Lopez, B. Adamo, I. Teruel-Garcia, J. Ponce, M. González-Cordero, G. Viñas Villaro, L. Lema Roso, F.J. Salvador Bofill, M.T. M. Martinez, A.N.E. Guerrero, A. Prat, V. Serra Elizalde
Journal: Annals of Oncology (2022)
ENDOSCOPIC CLOSURE OF BRONCHO-ESOPHAGEAL FISTULA (BEF) OCCURRING AS AN ADVERSE EVENT FOLLOWING SUBMUCOSAL TUNNELING ENDOSCOPIC RESECTION (STER) OF AN ESOPHAGEAL LEIOMYOMA USING BIODEGRADABLE FISTULA PLUGS
Authors: A. Bapaye, A. Gandhi, B. Pawar, J. Ansari, H. Raina, H. Bapaye, T. Nikumbh
Journal: Endoscopy (2022)

35-y-male,STER-esophageal leiomyoma(4x3cm)at 24–28cm. Inadvertent mucosal diathermy injury over tunnel–endo-clipped. Contrast study–no leak.Oral diet-48hours& discharge 4-days later. 2-weeks post-STER–cough on swallowing.CECT – BEF.EGD–mucosal breakdown at diathermy injury site;bronchoscopy–BEF–right main bronchus.
ESOPHAGEAL VESICLES: ENDOSCOPIC, HISTOLOGIC AND ELECTRONMICROSCOPIC DESCRIPTION OF NOVEL LESIONS AT THE GASTROESOOPHAGEAL JUNCTION
Authors: K. Mönkemüller, L. Fry, C. Delgado-Linares, A. Martínez-Alcalá
Journal: Endoscopy (2022)

Aims During upper endoscopy we have often observed the presence of small yellow vesicles above the Z-line. These lesions have not been described in the literature.
68Ga-DOTANOC PET/CT Detects a Rare Case of Metastatic Neuroendocrine Neoplasm of the Gallbladder
Authors: Abhishek Kumar, Bhola Kumar, Gopal Sonai Muthu, Sujata Mitra
Journal: Clinical Nuclear Medicine (2022)

Gallbladder neuroendocrine neoplasms (NENs) are rare tumors of the biliary system. These neoplasms express somatostatin receptors, and hence radiolabeled somatostatin analog 68Ga-DOTANOC is used as a PET radiotracer in detection and staging. Gallbladder NEN cannot be differentiated from an adenocarcinoma of the gallbladder based on clinical symptoms or routine radiological imaging such as ultrasound or CT. These are either diagnosed postcholecystectomy or after biopsy from primary or metastatic sites. We present a rare case of gallbladder NEN detected on 68Ga-DOTANOC PET/CT.
THE USE OF ROSE AND TOUCH IMPRINT CYTOLOGY (TIC) FOR THE DIAGNOSIS OF SOLID PANCREATIC TUMORS. A RETROSPECTIVE STUDY
Authors: M. Fragaki, P. Nikolaou, E. Voudoukis, M. Vrontaki, G. Kazamias, E. Chliara, E. Mastorakis, G. Paspatis
Journal: Endoscopy (2022)

Aims Endoscopic ultrasound (EUS) combined with the cytological examination, has significantly improved the diagnostic evaluation of patients with solid tumors in the pancreas. ROSE (Rapid On Site Evaluation) has a major role in the immediate and reliable diagnostic approach. The aim of this study was to evaluate the role of ROSE combined with TIC (isolation of blood clots from smears) in solid pancreatic tumors found by EUS.
EFFICACY AND SAFETY OF DIGITAL SINGLE-OPERATOR CHOLANGIOPANCREATOSCOPY IN ELDERLY PATIENTS IN A TERTIARY REFERRAL CENTER
Authors: M. Gesualdo, M. Sacco, E. Dall'Amico, F. Cravero, M.T. Staiano, F. Fimiano, A. Mauriello, F. Castellano, C.G. De Angelis
Journal: Endoscopy (2022)

Aims Digital single-operator cholangioscopy (DSOC) became a key element in diagnosis and treatment of pancreato-biliary diseases, as difficult lithiasis or indeterminate strictures. Data about safety and efficacy of DSOC in patients older than 70 years are scanty; aim of this study is to assess safety and efficacy of DSOC in this population.
ARTIFICIAL INTELLIGENCE AND CAPSULE ENDOSCOPY: AUTOMATIC CLASSIFICATION OF SMALL BOWEL PREPARATION USING A CONVOLUTIONAL NEURAL NETWORK
Authors: T. Ribeiro, M.J. Mascarenhas Saraiva, J. Afonso, P. Andrade, H. Cardoso, J. Ferreira, M. Mascarenhas Saraiva, G. Macedo
Journal: Endoscopy (2022)

Aims Capsule endoscopy (CE) allows non-invasive inspection of the small bowel. An adequate bowel preparation is crucial for a conclusive exam. The application of artificial intelligence (AI) algorithms to endoscopy has produced promising results. Convolutional neural networks (CNNs) are a highly efficient architecture designed for image analysis. To date, no AI-based model has been developed for evaluation of bowel preparation in CE. We aimed to develop a deep learning model for automatic classification of bowel preparation in CE.
ACCURACY OF TEXTURE AND COLOUR ENHANCEMENT (TXI), A NOVEL IMAGE ENHANCEMENT MODALITY, IN PREDICTING RESIDUAL NEOPLASIA IN COLONIC ENDOSCOPIC RESECTION SCARS
Authors: S. John, M. Mickenbecker, A. Lyon
Journal: Endoscopy (2022)

Aims Residual neoplasia after complete resection of colon polyps has been reported in 10-32% and most can be treated endoscopically. TXI is a novel retinex-based image enhancement technology that changes texture, brightness, and colour of white light to increase the detection of subtle lesions. Narrow band imaging (NBI) has previously been reported to be accurate in predicting the presence of residual polyps. We assessed the accuracy of TXI in this regard.
SUBOPTIMAL ADEQUACY OF EUS-GUIDED TISSUE ACQUISITION FOR PANCREATIC TUMORS OF THE HEAD/UNCINATE. WHAT IS THE ROLE OF FIBROSIS?
Authors: T. Togliani, A. Lisotti, R. Rinaldi, S. Pilati, P. Fusaroli
Journal: Endoscopy (2022)

Aims The aim of this study was to compare the adequacy of pancreatic EUS-guided tissue acquisition with the fibrosis of the specimens.
T1 COLORECTAL CANCER TREATED BY ENDOSCOPIC RESECTION: IS THE PROGNOSIS DIFFERENT BETWEEN RECTAL AND COLON TUMORS?
Authors: F. Corre, M. Barret, T. Lambin, J.-P. Ratone, V. Lepilliez, E. Coron, J. Albouys, G. Rahmi, D. Karsenti, J.-M. Canard, E. Chabrun, M. Camus, T. Wallenhorst, M. François, R. Gerard, A. Rouquette, B. Terris, R. Coriat, M. Pioche, J. Jacques, S. Chaussade
Journal: Endoscopy (2022)

Aims Several studies suggest that rectal tumors have a poorer prognosis than colon tumors. The objective of this study was to compare the prognosis between T1 colon cancers and T1 rectal cancers treated by endoscopic resection.
ENDOSCOPIC AND SURGICAL TREATMENT OF AMPULLARY TUMORS: A SINGLE CENTER STUDY
Authors: M. Potrusil, J. Hlavsa, Z. Kala, R. Kroupa, H. Kolovratnikova, D. Sochorova, P. Janecek, T. Andrasina, L. Kunovsky
Journal: Endoscopy (2022)

Aims Neoplastic tumors of the ampulla of Vater are rare. Pathologically benign lesions are primarily indicated for endoscopic treatment. Cases of early adenocarcinomas affecting only the mucosa might be resolved by endoscopic resection in selected patients. Tumors infiltrating deeper layers of the wall must be removed by radical surgery.
BIDIRECTIONAL RECANALIZATION OF A COMPLETE POSTRADIATION STRICTURE OF THE HYPOPHARYNX AND ESOPHAGUS
Authors: G. Mavrogenis, F. Bazerbachi, K. Markoglou, S. Porceddu, S. Gupta, L. Hourigan
Journal: Endoscopy (2022)

Aim A 65-year-old patient was referred for management of a 5-cm long complete postradiation stricture of the hypopharynx and esophagus. Endoscopic bidirectional recanalization was planned.
EUS-GUIDED FIDUCIAL MARKERS IMPLANTATION FOR PRECISE LOCALIZATION OF PANCREATIC NET
Authors: S. Deiana, T. Gabbani, G. Impellizzeri, L. Ottaviani, J. Rainer, A. Curatolo, G.F. Bonura, P. Biancheri, P. Soriani, M. Manno
Journal: Endoscopy (2022)

A 73-year-old man was referred with weight loss and newly diagnosed diabetes. Abdominal CT and MRI scans showed non-specific enlarged pancreatic body without focal lesions. Conversely, EUS revealed a 21×17mm irregular, well-defined lesion within the pancreatic body, with hypoechoic capsule and intense enhancement after contrast medium injection, suspicious for a NET, in a context of chronic pancreatitis. FNB and histological examination confirmed the diagnosis of NET. To facilitate NET localization during surgery, we performed EUS-guided fiducial marker implantation. Fiducial marker visualization on intraoperative ultrasound scan aided the precise localization of the pancreatic NET, and successful distal splenopancreasectomy was performed.
Why covid vaccine studies are still needed
Authors: Andrew Ustianowski
Journal: BMJ (2022)

Why covid vaccine studies are still neededWe still have much to learn from research on covid-19 vaccines, says Andrew Ustianowski Andrew Ustianowski clinical lead for the COVID Vaccine Research ProgrammeWith spring booster jabs being deployed across the UK for people aged 75 and over and those with suppressed immune systems, many may assume that research on covid-19 vaccines is now complete.However, as we all know, SARS-CoV-2 has the ability to mutate, leading to new waves of covid-19 infection that can cause illness and death, strain healthcare services, and harm the economy.This is why vaccine research remains vital to our ongoing protection from covid-19.
BALLOON-ASSISTED ENTEROSCOPY AND MOTORIZED SPIRAL ENTEROSCOPY: COMPETITIVE OR COMPLEMENTARY TECHNIQUES ?
Authors: T. Moreels, L. Monino, P. Deprez, H. Piessevaux
Journal: Endoscopy (2022)

Aims To compare technical efficacy (insertion depth), of motorized spiral enteroscopy (MSE) and single-balloon enteroscopy (SBE) consecutively performed in the same patients cohort.
RISK OF CANCER IN LARGE COLORECTAL POLYPS: DO SIZE AND LOCATION MATTER?
Authors: H. Htet, K. Siggens, S. Aslam, M. Abdelrahim, S. Subramaniam, P. Bhandari
Journal: Endoscopy (2022)

Aims Polyp size and location have been associated with high incidence of covert cancer rates of up to 10% even after expert assessment. We aim to evaluate the risk of cancer in large colorectal polyps resected via endoscopic submucosal dissection (ESD) or knife-assisted resection (KAR).
METACHRONOUS PANCREATIC METASTASIS FROM COLON CANCER DIAGNOSED BY ENDOSCOPIC ULTRASOUND-GUIDED FINE NEEDLE BIOPSY (EUS-FNB)
Authors: S. Rizza, C. Laudi, E. Maldi, T. Staiano
Journal: Endoscopy (2022)

Aims Pancreatic metastases are rare (2% of pancreatic neoplasms). They can appear long after the initial surgery and primary cancer most frequently associated is renal cell carcinoma. Preoperative diagnosis is very challenging.
THE USE OF GASTRODUODENAL FULL-THICKNESS RESECTION DEVICE (FTRD) FOR THE TREATMENT OF UPPER GASTROINTESTINAL LESION
Authors: G. Kranidiotis, N. Tsoukalas, A. Trikola, S. Sgouros, K. Vasileiadis, G. Stefanidis
Journal: Endoscopy (2022)

We perfomed endoscopic full-thickness resection using the gastroduodenal FTRD in order to resect a submucosal lesion of 14mm in the antrum of stomach of a 58 years old male patient. Technical success and R0 resection was achieved with a procedural time of 26 min. Histopathological analysis confirmed R0 resection and demonstrated a definite diagnosis of a gastrointestinal stromal tumor (GIST). No adverse events noted and the patient did not require hospitalization or further intervention.
PAIRED WORKING COMBINED WITH ON-DEMAND DIRECT EXPERT SUPERVISION ALLOWS A SAFE AND EFFECTIVE IMPLEMENTATION OF RECTAL ENDOSCOPIC SUBMUCOSAL DISSECTION IN A NON-ACADEMIC REFERRAL HOSPITAL
Authors: P. Leclercq, G. Bastens, O. Plomteux, N. Bletard, P. Demaret, R. Bisschops, V. Lepilliez
Journal: Endoscopy (2022)

Aims We evaluated the efficacy and the safety of rectal endoscopic submucosal dissection (ESD) implementation in a non-academic referral hospital performed in operator pairs associated with on-demand direct expert supervision.
Polymeric dual-modal imaging nanoprobe with two-photon aggregation-induced emission for fluorescence imaging and gadolinium-chelation for magnetic resonance imaging
Authors: Xueyang Xiao, Hao Cai, Qiaorong Huang, Bing Wang, Xiaoming Wang, Qiang Luo, Yinggang Li, Hu Zhang, Qiyong Gong, Xuelei Ma, Zhongwei Gu, Kui Luo
Journal: Bioactive Materials (2022)

Nanoprobes that offer both fluorescence imaging (FI) and magnetic resonance imaging (MRI) can provide supplementary information and hold synergistic advantages. However, synthesis of such dual-modality imaging probes that simultaneously exhibit tunability of functional groups, high stability, great biocompatibility and desired dual-modality imaging results remains challenging. In this study, we used an amphiphilic block polymer from (ethylene glycol) methyl ether methacrylate (OEGMA) and N-(2-hydroxypropyl) methacrylamide (HPMA) derivatives as a carrier to conjugate a MR contrast agent, Gd-DOTA, and a two-photon fluorophore with an aggregation-induced emission (AIE) effect, TPBP, to construct a MR/two-photon fluorescence dual-modality contrast agent, Gd-DOTA-TPBP. Incorporation of gadolinium in the hydrophilic chain segment of the OEGMA-based carrier resulted in a high r1 value for Gd-DOTA-TPBP, revealing a great MR imaging resolution. The contrast agent specifically accumulated in the tumor region, allowing a long enhancement duration for vascular and tumor contrast-enhanced MR imaging. Meanwhile, coupling TPBP with AIE properties to the hydrophobic chain segment of the carrier not only improved its water solubility and reduced its cytotoxicity, but also significantly enhanced its imaging performance in an aqueous phase. Gd-DOTA-TPBP was also demonstrated to act as an excellent fluorescence probe for two-photon-excited bioimaging with higher resolution and greater sensitivity than MRI. Since high-resolution, complementary MRI/FI dual-modal images were acquired at both cellular and tissue levels in tumor-bearing mice after application of Gd-DOTA-TPBP, it has great potential in the early phase of disease diagnosis.
ENDOSCOPIC REMOVAL OF A SHARP ESOPHAGEAL FOREIGN BODY: CHALLENGES FACED
Authors: P.N. Desai, C. Patel, R. Prajapati, M. Kabrawala, N. Patel, M. Sethia, R. Mehta, S. Nandwani
Journal: Endoscopy (2022)

45-year-male with dysphagia one and half months after eating fish. X-ray neck – foreign body in neck. CT neck showed a V shaped bone located horizontally in proximal esophagus. No free perforation or vascular impingement.EGD revealed V shaped bone both ends and base embedded in proximal esophageal wall. Distal and proximal wings of V dislodged one by one with rat tooth and removal attempted. Falied. Base dislodged from esophageal wall taking care that end of wings did not further impinge opposite wall. The V then pulled out holding the base and two arms vertical. Ryle's tube placed for feeding.
IMPACT OF THE COVID-19 PANDEMIC ON UPPER GASTROINTESTINAL ENDOSCOPY ACTIVITY
Authors: R. Tababi, S. Mrabet, A. Hassine, R. Harbi, I. Akkari, A. Hassine, E. Ben Jazia
Journal: Endoscopy (2022)

Aims The Coronavirus-disease-2019 (COVID19) pandemic has clearly disrupted healthcare systems. Gastrointestinal endoscopy has been affected as well. This study aimed to evaluate the effect on upper gastrointestinal endoscopy (UGE) activity in terms of volume alongside indications and results.
RARE LONG-TERM SEQUELAE OF USE OF CARDIAC SEPTAL OCCLUDER DEVICE FOR TRACHEO-OESOPHAGEAL FISTULA CLOSURE IN COVID TIMES
Authors: A. Kale, M. Dodmani, M. Satai, S. Sundaram, A. Singh, M. Aggarwal, A. Shukla
Journal: Endoscopy (2022)

Long-term outcomes of tracheo-esophageal fistula(TEF) closure using atrial septal defect occluder (ASDO) are unknown.
INCORPORATING ESGE GUIDANCE INTO LIVE ENDOSCOPY EDUCATION – LESSONS FOR THE PERI AND POST-COVID ERA
Authors: T. El Menabawey, D. Graham, S. Phillpotts, G. Webster
Journal: Endoscopy (2022)

Aims Live Endoscopy Events (LEEs) are used to disseminate expert practice. However, there is minimal evidence to support the format and learning objectives are rarely explicit. Social distancing has forced a rethink of how LEEs are delivered online and ESGE have published an updated position statement in 2021. Recommendations include the use of pre-recorded cases and publishing learning objectives written with Bloom’s Taxonomy (to describe the cognitive processes by which learners engage with knowledge).
Errors in Abstract, Introduction, and Methods
Journal: JAMA Network Open (2022)

Screening by Poor Health Status andRace and Ethnicity in US Adults, 2017 to 2020," 1 published March 31, 2022, there were errors in the Abstract, Introduction, and Methods.These sections should have stated that participants had a greater than or equal to 30 pack-year smoking history.This article has been corrected.
ENDOSCOPIC SUBMUCOSAL DISSECTION IN A WESTERN NON-ACADEMIC CENTRE – INITIAL EXPERIENCE
Authors: F. Pereira Correia, F. Bordalo Ferreira, M. Cardoso, L. Carvalho Lourenço, A. Martins
Journal: Endoscopy (2022)

Aims Endoscopic submucosal dissection (ESD) is a technique developed in East Asia that allows the resection of histologically advanced epithelial lesions. In the last years, in the Western World, experience in this procedure has been increasing, with several published studies showing good results. Our aim is to show the results of ESD carried out in a non-academic centre in a western country.
62P Outcomes of high-risk breast cancer (BC) patients from El Álamo IV registry and GEICAM adjuvant clinical trials
Authors: M. Martin Jimenez, A. Rodríguez-Lescure, R. Andres Conejero, S. Servitja Tormo, A. Anton Torres, M. Ruiz Borrego, B. Bermejo De Las Heras, A. Guerrero, M. Ramos Vazquez, A. Santaballa Bertran, M. Munoz, J.N. Batista, S. Lopez-Tarruella Cobo, J.I. Chacon Lopez-Muniz, I. Alvarez Lopez, M.P. Martinez del Prado, J.J. Miralles, O. Polonio, C. Jara Sanchez, M. Mori de Santiago
Journal: Annals of Oncology (2022)
69P Impact of statin use on survival outcomes of patients with HER2-positive early breast cancer in the APHINITY trial
Authors: C. Maurer, E. Agostinetto, L. Ameye, M. Lambertini, S. Martel, N.F. Ponde, M. Brandão, F. Poggio, A.R. Ferreira, R. Schiff, C. De Angelis, R.D. Gelber, S. Dent, C. Thomssen, M. Piccart, E. de Azambuja
Journal: Annals of Oncology (2022)
NEXT-GENERATION SEQUENCING MUTATIONAL ANALYSIS OF CELL-FREE DNA IN ERCP-OBTAINED BILE. A STEP FORWARD IN THE DIAGNOSIS OF MALIGNANT BILIARY STENOSIS
Authors: M. Rullan, D. Oyon, L. Zabalza, P. Salmón, V. Jusué, M. Mercado, B. González de la Higuera, I. Amat, J. Carrascosa, I. Fernández-Urien, D. Ruiz-Clavijo, M. Casi, E. Borobio, C. Saldaña, F. Bolado, M. Arechederra, C. Berasain, M.A Avila, J.M Urman, J.J. Vila
Journal: Endoscopy (2022)

Aims The discrimination between benign and malignant biliary stenosis (BS) remains a clinical challenge. The diagnostic accuracy of bile duct brushing cytology is suboptimal. Liquid biopsy strategies could improve this diagnostic accuracy. The aim of this study was to evaluate the diagnostic yield of ERCP-bile duct brushing cytology versus next-generation sequencing mutational analysis of cell-free DNA in ERCP-obtained bile (Bilemut) in patients with BS at the time of first ERCP.
91MO Randomized trial of neoadjuvant chemotherapy with or without concurrent aromatase inhibitor therapy to downstage ER+ve breast cancer: Breast Cancer Trials Group ANZ 1401 ELIMINATE trial
Authors: N. Murray, P. Francis, N. Zdenkowski, N. Wilcken, F. Boyle, V. Gebski, S.M. Tiley, L. Gilham, S-J. Dawson, S. Loi, A.D. Redfern, J. Lombard, A. Spillane, C. Shadbolt, H. Badger
Journal: Annals of Oncology (2022)
Age at Initiation of Lower Gastrointestinal Endoscopy and Colorectal Cancer Risk Among US Women
Authors: Wenjie Ma, Molin Wang, Kai Wang, Yin Cao, Ellen Hertzmark, Shuji Ogino, Kimmie Ng, Walter C. Willett, Edward L. Giovannucci, Mingyang Song, Andrew T. Chan
Journal: JAMA Oncology (2022)

<h3>Importance</h3> In the past 4 years, the American Cancer Society and the US Preventive Services Task Force updated recommendations to initiate colorectal cancer (CRC) screening at 45 years of age to address the increasing incidence of CRC among adults younger than 50 years. However, empirical evidence evaluating the potential benefits of screening in younger populations is scant. <h3>Objective</h3> To examine the association between endoscopy initiation at different ages and risk of CRC among US women. <h3>Design, Setting, and Participants</h3> This prospective cohort study used data from the Nurses' Health Study II, which included US female health professionals followed up from 1991 through 2017. Data analysis was performed from August 2020 to June 2021. <h3>Exposure</h3> Age at initiation of sigmoidoscopy or colonoscopy for screening (routine screening or because of family history) or symptoms. <h3>Main Outcomes and Measures</h3> Incident CRC, confirmed by medical records, pathology reports, and the National Death Index. Cumulative incidence of CRC in each group was estimated with age as the time scale, and the absolute risk reduction associated with endoscopy initiation at different ages through 60 years was calculated. Cox proportional hazards regression was used to calculate hazard ratios (HRs) and 95% CIs, stratified by age and calendar year of questionnaire cycle and adjusted for CRC risk factors in the multivariable models. <h3>Results</h3> Among 111 801 women aged 26 to 46 years (median, 36 years) at enrollment, 519 incident CRC cases were documented over 26 years, encompassing 2 509 358 person-years of follow-up. In the multivariable analysis, compared with no endoscopy, undergoing endoscopy was associated with a significantly lower risk of incident CRC for age at initiation before 45 years (HR, 0.37; 95% CI, 0.26-0.53), 45 to 49 years (HR, 0.43; 95% CI, 0.29-0.62), 50 to 54 years (HR, 0.47; 95% CI, 0.35-0.62), and 55 years or older (HR, 0.46; 95% CI, 0.30-0.69). The absolute reduction in the estimated cumulative incidence of CRC through 60 years of age was 72 per 100 000 persons for initiation of endoscopy at 45 to 49 years of age vs 50 to 54 years of age. Compared with no endoscopy, initiation of endoscopy before 50 years of age was also associated with a reduced risk of CRC diagnosed before 55 years of age (&lt;45 years: HR, 0.45 [95% CI, 0.29-0.70]; 45-49 years: HR, 0.43 [95% CI, 0.24-0.76]). <h3>Conclusions and Relevance</h3> In this cohort study, compared with no endoscopy, initiation of endoscopy before 50 years of age was associated with a reduced risk of CRC, including CRC diagnosed before 55 years of age. Screening before 50 years of age was associated with greater absolute reduction in CRC risk compared with initiation of CRC screening at 50 years of age or later.