tbuckley/cabot-search huggingface dataset:
Manuscripts Approved for JNCI, April 1 to May 1, 1968
Journal: JNCI Journal of the National Cancer Institute (1968)

Journal Article Manuscripts Approved for JNCI, April 1 to May 1, 1968 Get access JNCI: Journal of the National Cancer Institute, Volume 40, Issue 6, June 1968, Pages 1401–1402, https://doi.org/10.1093/jnci/40.6.1401-a Published: 01 June 1968
Treatment of narcotics addiction with narcotic drugs
Authors: R. L. DuPont
Journal: JAMA (1976)

WHILE THE use of methadone hydrochloride for both opiate maintenance and detoxification has been well described in the medical literature<sup>1-4</sup>during the past decade, recent legislation has expanded the boundaries of the federal regulatory role in drug-abuse treatment to cover the maintenance and detoxification of drug-dependent persons with all narcotic drugs. The little-known Narcotic Addict Treatment Act of 1974 (Public Law 93-281, May 1974) placed the federal government's control of methadone on a firm legal foundation. This additional control was accomplished by giving to the Drug Enforcement Administration (DEA) of the Department of Justice the responsibility for registering all practitioners who use methadone or other narcotic drugs in the treatment of narcotics addiction. <h3>Registration</h3> The Secretary of Health, Education, and Welfare (HEW), representing the interests of health professionals, must, under this act, publish treatment standards and advise the DEA whether applicants to conduct maintenance or detoxification treatment should be
Syphilis. An algorithm
Authors: T. J. Lee
Journal: JAMA (1979)

SINCE the development of the Wassermann complement-fixation test in 1906, laboratory tests have been invaluable aids in the diagnosis of syphilis. The use of these tests continues on a large scale, but their utility and interpretation are not always clear to the physician, who is the one who must make the critical decisions concerning treatment. The two basic types of serological tests currently available are nontreponemal and treponemal. The standard nontreponemal test used in the United States is the VDRL slide test. Other related tests include the rapid plasma reagin and unheated serum reagin tests. Since the antibody measured (reagin) can also be present transiently after immunizations or various febrile illnesses and chronically in conditions such as collagen vascular disease, leprosy, and drug addiction, VDRL test reactivity is not specific for syphilis. On the other hand, the VDRL test is easily quantitated, and serial titers are helpful in following the
Book Review Ultra-Violet Radiation . By Eleanor H. Russell, M.D., B.S., Dunelm, Honorary Physician Sun-Ray Clinic, Newcastle-on-Tyne, and W. Kerr Russell, M.D., B.S., Dunelm, Medical Director Sun-Ray Clinic, Newcastle -on-Tyne. Third Edition, William Wood &amp; Company, New York; E. &amp; S. Livingstone, Edinburgh. pp. 648. Price $6.50.
Journal: New England Journal of Medicine (1929)
Obscure intussusception diagnosed by ultrasonography
Authors: H. Uhland
Journal: JAMA (1978)

ILEOCOLIC intussusception, though common in children, is extremely rare in adults. To our knowledge, only 160 cases have been recorded in the literature since 1952.<sup>1</sup>A case of ileocolic intussusception in an elderly woman was diagnosed by ultrasonography. <h3>Report of a Case</h3> A 90-year-old woman entered the Emergency Department with a four-day history of diffuse midupper abdominal pain. At the time of admission, she had no nausea or vomiting. She had four watery, diarrheal stools, with no evidence of blood during the preceding 12 hours. Examination of the abdomen showed a 10- to 12-cm, tubular, firm, minimally tender mass located in the right side of the upper abdomen. Bowel sounds were hypoactive. Rectal examination was normal, and the stool was weakly positive for blood by guaiac determination. Results of a complete blood cell count and chemistry screen were normal. Plain films of the abdomen were normal. A barium examination
A simplified approach to meningococcal disease prophylaxis
Authors: J. A. Jacobson
Journal: JAMA (1976)

ALTHOUGH meningococcal disease is presently uncommon in the United States, the suddenness and severity with which it strikes and its epidemic potential frequently produce considerable anxiety in patient contacts. This may lead concerned physicians to take measures that are inappropriate or unnecessary. A recent editorial<sup>1</sup>defines in detail the type of contact associated with increased risk and reviews the prophylactic measures appropriate for reducing this risk. However, a study by the Meningococcal Disease Surveillance Group<sup>2</sup>indicates that physicians often do not administer antimicrobial prophylaxis to persons at increased risk and do administer prophylaxis to persons not shown to be at risk. The same study showed that when physicians give antibiotics, they often select ineffective ones. Additionally, it showed that considerable time and money are spent doing useless culture surveys of contacts. Because of this evident confusion about who would benefit from meningococcal prophylaxis, about what agents should be
Immunization of Children Infected with Human T-Lymphotropic Virus Type III/Lymphadenopathy-Associated Virus
Journal: Annals of Internal Medicine (1987)

This document is intended to summarize available information and to assist health-care providers in developing policies for the immunization of children infected with human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) [now known as the human immunodeficiency virus], the virus that causes acquired immunodeficiency syndrome (AIDS). These policies may vary depending upon the prevalence of HTLV-III/LAV infection and the incidence of vaccine-preventable diseases in the community, individual assessment of a child's health status, and the risks and benefits of immunization in a particular situation. This discussion considers the risks and benefits of immunization for children residing in the United States based on the risks of vaccine-preventable diseases and the prevalence of HTLV-III/LAV infection and is intended for use by health-care providers in the United States. The recommendations may not pertain to other countries with different risks of vaccine-preventable diseases and prevalence of HTLV-III/LAV infection among children. Since these recommendations are based upon information and knowledge available at this time, periodic reassessment and revision will be required as more data concerning risk and benefits associated with immunization of HTLV-III/LAV-infected children become known and as the prevalences of specific vaccine-preventable diseases and HTLV-III infection change.
Abstract 3746: Association of Gamma ′ Fibrinogen with Risk Factors and Prevalent Cardiovascular Disease in the Framingham Heart Study
Authors: Rehana S Lovely, Joseph F Massaro, Ralph B D’Agostino, Emelia J Benjamin, Steven C Kazmierczak, Christopher J O’Donnell, David H Farrell
Journal: Circulation (2007)

Background: γ′ fibrinogen is a newly-emerging cardiovascular disease (CVD) biomarker that has shown significant associations with coronary artery disease in small case/control studies. γ ′ fibrinogen is an isoform with an altered γ chain, and constitutes ∼10% of total fibrinogen. Both elevatedγ ′ and total fibrinogen cause fibrinolytic resistance in vitro . However, data are lacking from community based studies on the association ofγ ′ fibrinogen with CVD risk factors or with clinical CVD. Methods: γ ′ fibrinogen levels were measured using an ELISA assay in 3284 men and women in the Framingham Heart Study Offspring Cohort 7th examination cycle (2002– 05). Associations ofγ ′ fibrinogen were examined using linear regression for continuous CVD risk factors and logistic regression for prevalent CVD and other dichotomous measures. Results: The ELISA CV was 9.3% at meanγ ′ fibrinogen levels. Participants (mean age 60 years, 53.4% women) with prevalent CVD (0.297 ± 0.007 mg/ml; mean ± SE) had significantly higher mean concentrations than those without CVD (0.255 ± 0.002 mg/ml). There were significant (all p&lt;0.05) associations betweenγ ′ fibrinogen levels with several cardiovascular risk factors, including age, BMI, systolic blood pressure, diabetes mellitus, cigarette smoking, and total cholesterol, and an inverse association with HDL cholesterol. γ ′ fibrinogen was associated with prevalent CVD with an odds ratio of 1.76 (95% CI 1.06–2.92) for the highest compared to the lowest tertile, after adjustment for all of the above risk factors. As expected, sinceγ ′ fibrinogen constitutes a subset of total fibrinogen, γ ′ fibrinogen was correlated with total fibrinogen. However, if we included bothγ ′ and total fibrinogen in further analyses of association with CVD, the odds ratio was 3.08 (95% CI 1.41–6.72) for the combined tertile of both the highestγ ′ fibrinogen and highest total fibrinogen, an odds ratio that was substantially higher than that for either marker alone. Conclusions: γ ′ fibrinogen is associated with multiple CVD risk factors and with prevalent CVD, accounting for CVD risk factors, over and above total fibrinogen alone. Prospective studies are warranted to examine the ability ofγ ′ fibrinogen to predict CVD.
Do it to yourself section. The Kane surgery
Authors: D. Rennie
Journal: JAMA (1987)

THIS editor was intrigued and felt he could help. "The photo" Dr Hirsch had enclosed was a photocopy of a faded photograph from some unnamed newspaper. Elsewhere on the clipping was a reference to "Snoops applaud showgirls, hoist highballs, then raid lavish Club Calais on W. 51st St." That and an item about a Brooklyn sheriff who had allowed the county interest money to accrue to his private thrift account induced a comfortable feeling of déjà vu, and then a sad feeling of plus ça change, but it also suggested a place and therefore a paper:<i>The New York Times</i>. <i>The New York Times</i>of Feb 16,1921,<sup>1</sup>carried this "special": KANE. Pa, Feb. 15.—Dr. Evan O'Neill Kane, chief surgeon of Kane Summit Hospital, performed an operation upon himself for chronic appendicitis this forenoon. Sitting on the operating table propped up by pillows and with a nurse holding his head
Acute Effects of Cadmium on the Pregnant Rat and Embryo-Fetal Development
Authors: G. P. Samarawickrama, M. Webb
Journal: Environmental Health Perspectives (1979)

In rats, of the Wistar-Porton strain, a single intravenous injection of 1.25 mg Cd2+ between days 9 and 15 of gestation results in a high incidence (80% of hydrocephalus, together with other malformations in the fetuses, examined on day 20. This dose is critical, since 1.1 mg Cd2+/kg is not teratogenic, while 1.35 mg Cd2+/kg kills all the embryos. Intravenous injection of Cd2+ to the pregnant rat on day 12 causes a dose-dependent inhibition of placental Zn2+ transport. At the teratogenic dose, Zn2+ transport is inhibited by about 75% at 4 hr. Thereafter, inhibition decreases with time but is still significant at 48 hr. At 20 hr after administration of Cd2+ the embryonic concentration of Zn2+ is depressed by 33%. In the whole embryo the activity of the Zn2+-dependent thymidine kinase is inhibited by about 60% at 4 hr and at 20 hr the DNA concentration is reduced significantly. Placental transport of 14C-leucine and 14C-uridine, as well as the embryonic incorporation of these precursors into protein and RNA is unaffected at least at short times after the administration of Cd2+. It is possible therefore, that the teratogenic effects of Cd2+ may be related to the inhibition of DNA synthesis in the embryo.
Medicare’s Bundled Payment Program and Health Care Utilization—Reply
Authors: Matthew J. Press, Rahul Rajkumar, Patrick H. Conway
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Index to advertisers
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NECROLOGY.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An unusual cause of obscure gastrointestinal bleeding
Authors: H-H Yen, Y-Y Chen, M-S Soon, Y-M Lin
Journal: Gut (2006)

Vesicular stomatitis virus (VSV) infection rapidly induces IFN-αβ that confers initial survival, whereas long-term protection is mediated by neutralizing IgG responses. Because coadministration of IFN-αβ can enhance Ab responses against soluble Ags, we addressed whether virus-induced IFN-αβ also had an impact on the induction of neutralizing Ab responses. To this end, we generated apathogenic retrovirus-like particles (VLP) displaying the VSV gp (VLP-VSV). Reminiscent of live VSV, VLP-VSV induced VSV-neutralizing IgM responses that switched to IgG in a T help-dependent manner. In type I IFN receptor-deficient (IFNAR<sup>−/−</sup>) mice, VLP-VSV injection elicited neutralizing IgM, whereas the IgG switch was absent. The lack of subclass switch was associated with a reduced germinal center reaction. Conditional knockout mice with a lymphocyte-specific IFNAR ablation showed normal Ab responses against VLP-VSV, as well as against live VSV. Thus, IFNAR triggering critically promoted the T help-dependent subclass switch of virus-neutralizing Ab responses against VLP-VSV. Interestingly, in the context of VLP-VSV as well as VSV immunization, IFNAR triggering of B lymphocytes did not play a critical role.
Hypothermia-Related Deaths—Virginia, November 1996-April 1997
Journal: JAMA (1998)

Hypothermia is defined as a central or core body temperature of < or =95 F (< or =35 C) and is a medical emergency. Persons with hypothermia are at high risk for death. Although hypothermia-related deaths are common during winter months in states characterized by cold winters (e.g., Alaska and North Dakota) and with mountainous or desert terrain (e.g., Arizona and New Mexico), hypothermia and associated deaths also occur in states with milder climates. For example, during November 1996-April 1997, the Chief Medical Examiner's Office in Virginia identified 20 deaths caused by hypothermia; of these, 11 (55%) were among men and decedents ranged in age from 22 to 86 years (mean: 63 years). This report describes selected cases of hypothermia-related deaths in Virginia during November 1996-April 1997 and summarizes hypothermia-related deaths in the United States during 1979-1994.
Factors associated with intellectual ability of children born to mothers with high risk pregnancies
Authors: M. Ounsted, C W G Redman
Journal: BMJ (1984)

there was no evidence of mental illness or mental handicap, and I thought that he had a severe personality disorder.The interesting feature about this patient is that he presented me with a newspaper clipping of his court hearing where the judge was quoted as saying, "This man clearly needs psychiatric treatment for his violence."The prisoner then said, "I've come to have my violence cured doctor."This example augments Dr Smith's com- ments that the courts have great expectations about what psychiatry can offer these people.The concepts of "medicalisation" and "cure" for violent behaviour are still common and, as psychiatrists, we should try to increase the understanding of the courts as to what we can and cannot offer.
Editorial Board
Authors: Don Minckler, Rohit Varma, Los Angeles, Douglas Miami, George Bartley, Roy Tampa, Mark Blumenkranz, James Brandt Sacramento, Susan Day, San Francisco, Robert Drews, Ann Dawson Managing, Robert Folberg, William Freeman, Ira Jolla, Peter Hamilton, Glenn Durham, Robert Seattle, Yoshiaki Wa, Ronald Madison, Richard Alan, Lewis Houston, Maureen Maguire Philadelphia, Joel Mindel, New York, David Musch, Ann Arbor, Joan Mi, San O'brien, Denis Francisco, William Spencer, Roger Steinert Boston, Richard Stone Philadelphia, Alan Sugar, Andrea Mi, Lake Tongue, Thomas Oswego
Journal: Ophthalmology (1998)
Selected New Books
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum for the Research Article: “Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice” by V. Favaudon, L. Caplier, V. Monceau, F. Pouzoulet, M. Sayarath, C. Fouillade, M.-F. Poupon, I. Brito, P. Hupé, J. Bourhis, J. Hall, J.-J. Fontaine, M.-C. Vozenin
Journal: Science Translational Medicine (2019)
Papillomavirus invades esophagus, incidence seems to be increasing
Authors: M. F. Goldsmith
Journal: JAMA (1984)

Infection of the esophagus by human papillomavirus (HPV)—an agent that some studies have linked to the development of intraepithelial neoplasia and invasive squamous cell carcinoma in other body areas (<i>Cancer Res</i>1979;39:1074-1082,<i>Int J Gynecol Pathol</i>1982; 1:75-94)—was reported for what is believed to be the first time at the recent meeting of the International Academy of Pathology in San Francisco. And, the principal investigator told<i>JAMA</i>MEDICAL NEWS, incidence of the virus, which is acquired either congenitally or through sexual transmission, may be increasing because of an apparent growing prevalence of oral-genital sexual intercourse. The study continues. The investigator, Barbara Winkler, MD, assistant professor of pathology, State University of New York at Stony Brook School of Medicine, told the group that while hyperplastic and papillomatous lesions of the esophagus have been mentioned sporadically in the literature since the early 1920s, the incidence of true squamous papillomas of the esophagus
斑秃: 疾病发生机理回顾
Authors: F. Rajabi, L.A. Drake, M.M. Senna, N. Rezaei
Journal: British Journal of Dermatology (2018)

斑秃是一种导致脱发的疾病, 但它并非总是一成不变, 且病程是不可预测的。此病通常表现为胡须或头皮上的小块可逆性毛发脱落, 易于治疗。它也可导致整个头皮脱发 (称为全秃), 在某些患者中可造成毁灭性的心理影响, 不当的治疗和频繁的复发。本文是伊朗和美国学者们对导致斑秃的主要事件进行的描述性回顾。很多环境和遗传因素与斑秃的发生有关, 但主要事件是免疫系统对毛囊发起攻击, 而免疫系统通常是用于保护机体免受有害“外来”物质或疾病侵犯。在正常状态下, 毛囊处在免疫系统所及以外的庇护当中。这种庇护的破坏会激活针对毛囊的免疫细胞。由于毛囊从未暴露在免疫系统之下, 因此免疫系统将它们识别为异物, 这就是激活的原因。什么导致这种破坏是一个存有争议的话题。它可能是中枢免疫系统出现问题或毛囊环境紊乱 (即贴近毛囊) 的结果。还确立了心理应激与斑秃启动和恶化的联系。一种称为肥大细胞的细胞系是免疫 (免疫系统)事件和心理应激之间的联系纽带。应激激活肥大细胞, 导致释放组胺和其他致炎因子。近些年来已经出现了多种针对免疫靶点的治疗策略 (称为生物制剂), 但大部分尚不能实现长期缓解。这可能是免疫事件的复杂性(不能通过单一制剂覆盖所有靶点) 导致的。忽略旨在治疗后促使毛发再生的策略 (以恢复免疫庇护) 可能是治疗失败的另一个原因。
Hospitality for Overseas Visitors
Authors: H. A. Sandiford
Journal: BMJ (1949)

The Pennsylvanian and Permian strata in the Appalachian basin are generally interpreted to be the erosional record of the Alleghanian orogeny. Advances in our understanding of the kinematic and tectonic history of the Alleghanian orogen from study of the orogenic interior have not been integrated into interpretations of the late Paleozoic stratigraphic record. This comparative study of detrital-zircon U-Pb ages from the youngest preserved synorogenic deposits in the Alleghanian foreland (Permian Dunkard Group) to previously published ages from Early and Middle Pennsylvanian-age deposits reveals a subtle, but perhaps significant, shift in the detrital-zircon-age population. The Permian detrital-zircon ages lack 1700 to 1900 Ma and Archean-age grains characteristically present in the Pennsylvanian-age deposits, which are interpreted to indicate recycling of the lower Paleozoic passive margin. Instead, the Permian detrital-zircon-age populations are representative of the ages of rocks within the Appalachian orogenic interior. This change in the detrital-zircon-age population correlates temporally to a shift from transpressionally-inspired oblique deformation during the Pennsylvanian to foreland-vergent contraction during the Early Permian. The study demonstrates the utility of detrital-zircon dating in sedimentary basins associated with complex and protracted tectonism beyond what can be ascertained by petrographic techniques alone.