tbuckley/cabot-search huggingface dataset:
In nonhospitalized, unvaccinated adults with COVID-19, molnupiravir reduced hospitalization or death at 29 d
Authors: Henry S. Sacks
Journal: Annals of Internal Medicine (2022)

ACP Journal ClubApril 2022In nonhospitalized, unvaccinated adults with COVID-19, molnupiravir reduced hospitalization or death at 29 dHenry S. Sacks, PhD, MDHenry S. Sacks, PhD, MDIcahn School of Medicine at Mount Sinai, New York, New York, USA (H.S.S.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/J22-0017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationJayk Bernal A, Gomes da Silva MM, Musungaie DB, et al. Molnupiravir for oral treatment of Covid-19 in nonhospitalized patients. N Engl J Med. 2022;386:509-20. https://pubmed.ncbi.nlm.nih.gov/34914868Clinical Impact RatingsGIM/FP/GP: References1. National Institutes of Health. Therapeutic management of nonhospitalized adults with COVID-19. Last updated 1 Feb 2022. Accessed at www.covid19treatmentguidelines.nih.gov/therapies/statement-on-therapies-for-high-risk-nonhospitalized-patients/ on 8 Mar 2022. Google Scholar2. National Institutes of Health. The COVID-19 Treatment Guidelines Panel's interim statement on patient prioritization for outpatient anti-SARS-CoV-2 therapies or preventive strategies when there are logistical or supply constraints. Last updated 23 Dec 2021. Accessed at www.covid19treatmentguidelines.nih.gov/therapies/statement-on-patient-prioritization-for-outpatient-therapies/ on 24 Jan 2022. Google Scholar3. Gandhi RT, Malani PN, Del Rio C. COVID-19 therapeutics for nonhospitalized patients. JAMA. 2022;327:617-8. [PMID: 35029659] Google Scholar Author, Article, and Disclosure InformationAffiliations: Icahn School of Medicine at Mount Sinai, New York, New York, USA (H.S.S.)Disclosures: The commentator has reported no disclosures of interest. The form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=J22-0017.This article was published at Annals.org on 05 April 2022. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics April 2022Volume 175, Issue 4Page: JC40KeywordsCOVID-19Chronic kidney diseaseChronic obstructive pulmonary diseaseDisclosureHeart diseasesHospitalizationsMedical risk factorsRenal cancerResearch laboratoriesTreatment guidelines ePublished: 5 April 2022 Issue Published: April 2022 Copyright & PermissionsCopyright © 2022 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
EUS GUIDED THROMBIN INJECTION OF PSEUDO AND TRUE ANEURYSM OF A BRANCH OF SPLENIC ARTERY
Authors: P.N. Desai, R. Prajapati, C. Patel, M. Kabrawala, M. Sethia, N. Patel, S. Nandwani, R. Mehta
Journal: Endoscopy (2022)

A 64 years male patient with abdominal pain 7 days. Hemoglobin 6.5 mg/dl, Ultrasound revealed 6 x 5 cm aneurysm in body of pancreas. CT angiogram -multiple microaneurysms in liver, kidneys, pancreas and spleen suggestive of polyarteritis nodosa, A 6 x 5 cm pseudoaneurysm in the pancreatic body from branch of splenic artery. A true aneurysm inside the pseudoaneurysm, mistaken as splenic artery. Pseudoaneurysm was punctured with 22G needle and 1 ml each of reconstituted thrombin+fibrinogen+aprotinin was injected simultaneously. True aneurysm still patent on CT and injected with thrombin and complete obliteration achieved.
Y<sup>90</sup>-radioembolisation in hepatocellular carcinoma induces immune responses calling for early treatment with multiple checkpoint blockers
Authors: Licia Rivoltini, Sherrie Bhoori, Chiara Camisaschi, Laura Bergamaschi, Luca Lalli, Paola Frati, Davide Citterio, Chiara Castelli, Vincenzo Mazzaferro
Journal: Gut (2022)
Benchmarking weakly-supervised deep learning pipelines for whole slide classification in computational pathology
Authors: Narmin Ghaffari Laleh, Hannah Sophie Muti, Chiara Maria Lavinia Loeffler, Amelie Echle, Oliver Lester Saldanha, Faisal Mahmood, Ming Y. Lu, Christian Trautwein, Rupert Langer, Bastian Dislich, Roman D. Buelow, Heike Irmgard Grabsch, Hermann Brenner, Jenny Chang-Claude, Elizabeth Alwers, Titus J. Brinker, Firas Khader, Daniel Truhn, Nadine T. Gaisa, Peter Boor, Michael Hoffmeister, Volkmar Schulz, Jakob Nikolas Kather
Journal: Medical Image Analysis (2022)
An adverse lipoprotein phenotype—hypertriglyceridaemic hyperapolipoprotein B—and the long-term risk of type 2 diabetes: a prospective, longitudinal, observational cohort study
Authors: Karol M Pencina, Michael J Pencina, Line Dufresne, Michael Holmes, George Thanassoulis, Allan D Sniderman
Journal: The Lancet Healthy Longevity (2022)

BackgroundThis study examines the risk of new-onset diabetes in patients with hypertriglyceridaemic hyperapolipoprotein B (high triglycerides, high apolipoprotein B [apoB], low LDL cholesterol to apoB ratio, and low HDL cholesterol). The aim was to establish whether this lipoprotein phenotype identified a substantial group at high risk of developing diabetes over the next 20 years.MethodsIn this prospective, longitudinal, observational cohort study, we used data from the Framingham Offspring cohort (recruited in Framingham, MA, USA). Participants were aged 40–69 years and free of diabetes and cardiovascular disease at a baseline examination done between April, 1987, and November, 1991, and were followed up until March, 2014. Cox proportional hazards regression with hierarchical adjustment for age and sex, waist circumference, and fasting blood glucose were used to model the relationship between each lipid marker and incident diabetes, as well as the relationship between hypertriglyceridaemic hyperapoB (defined as values greater than sample medians of triglycerides and apoB, and less than medians of HDL cholesterol and LDL cholesterol to apoB ratio) and incident diabetes.FindingsOf 3446 individuals aged 40–69 years who completed baseline examination, 2515 participants were eligible and included in all analyses. During median 21·1 years (IQR 11·1–23·1) of follow-up, 402 (16·0%) individuals developed diabetes. Age (p=0·032), waist circumference (p<0·0001), fasting blood glucose (p<0·0001), and natural logarithm-transformed triglycerides (p<0·0001) were associated with new-onset diabetes, as were apoB (p=0·0016), LDL cholesterol to apoB ratio (p=0·0018), and HDL cholesterol (p=0·0016) when added to this model. The age and sex-adjusted incidence of diabetes in the hypertriglyceridaemic hyperapoB group was 32·4% (95% CI 27·8–37·7) versus 5·5% (3·5–8·6) in the optimal lipid phenotype group and 15·5% (13·5–17·7) in the mixed lipid phenotype group. The fully adjusted hazard ratio, including glucose and waist circumference, for individuals with hypertriglyceridaemic hyperapoB was 3·30 (95% CI 2·06–5·30; p=0·0008) and for mixed lipid phenotype was 2·17 (1·38–3·40; p<0·0001) compared with those with the optimal lipid phenotype.InterpretationOur findings suggest that individuals with hypertriglyceridaemic hyperapoB are at high risk of new-onset diabetes and might benefit from intensive measures to prevent diabetes. The association between this phenotype and incident diabetes is consistent with a pro-diabetic effect due to increased clearance of apoB particles from plasma, which could injure pancreatic islet cells. This mechanism might explain the increased risk of diabetes with statin therapy.FundingDoggone Foundation.
PREGNANCY AFTER ESG: ARE ALL EFFORTS THWARTED? A CASE SERIES
Authors: G. Carlino, V. Bove, V. Pontecorvi, M. De Siena, M.V. Matteo, G. Giannetti, C. Massari, N. Antonini, G. Costamagna, I. Boškoski
Journal: Endoscopy (2022)

Aims A retrospective analysis of a prospective database was conducted to evaluate weight trajectories and lifestyle modification in women became pregnant after ESG
EXPERTS ENDOSCOPISTS VS. ARTIFICIAL INTELLIGENCE IN THE EVALUATION OF UNDETERMINED BILIARY STRICTURES IN CHOLANGIOSCOPY: A MULTICENTER, BLINDED, NESTED CONTROLLED TRIAL
Authors: C. Robles-Medranda, J. Alcivar-Vasquez, M. Kahaleh, I. Raijman, R. Kunda, A. Tyberg, A. Sarkar, H. Shahid, J.C. Mendez, J. Rodriguez, R.C. Merfea, J. Barreto Perez, M. Arevalo-Mora, M. Puga-Tejada, D. Calle-Loffredo, H. Alvarado, H.P. Lukashok
Journal: Endoscopy (2022)

Aims Digital single-operator cholangioscopy (DSOC) findings achieve high diagnostic accuracy for neoplastic bile duct lesions; however, endoscopists’ intra and interobserver agreements vary widely. We have recently proposed an AI model to classify bile duct lesions during real-time DSOC and currently pursue clinical validation of our AI model, compared with high DSOC experienced endoscopists.
One in two people admitted to hospital with covid-19 develop complications and may need support
Authors: Helen Saul, Deniz Gursul, Samantha Cassidy, Ewen Harrison
Journal: BMJ (2022)

The studyDrake TM, Riad AM, Fairfield CJ, et al. Characterisation of in-hospital complications associated with covid-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study. Lancet 2021;398:10296.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/one-in-two-people-hospitalised-with-covid-19-develop-complications-may-need-support/.
SUCCESSFUL TREATMENT OF ACHALASIA TYPE II WITH POEM
Authors: M. Lajin
Journal: Endoscopy (2022)

After submucosal injection, a mucosal incision was made using a triangular knife (Endocut current) at the posterior-lateral wall. The tunnel was entered and submucosal dissection was performed with spray coagulation extending the tunnel to 2 cm below the gastric cardia.
PREDICTORS OF FAILURE OF ENDOSCOPIC RETROGRADE CHOLANGIOGRAPHY IN CLEARING BILE DUCT STONE ON THE INITIAL PROCEDURE
Authors: A. Benhamdane, S. Mrabti, A. Touibi, T. Addajou, A. Sair, S. Rokhsi, R. Berraida, I. El Koti, F. Rouibaa, A. Benkirane, H. Seddik
Journal: Endoscopy (2022)

Aims Evaluate the predictive factors of failure rate of clearing the biliary system from stones at the initial ERCP.
KI67 AGREEMENT BETWEEN EUS-GUIDED SAMPLING (EUS-FNA/FNB) AND SURGICAL SPECIMEN IN PANCREATIC NEUROENDOCRINE NEOPLASMS (PNEN)
Authors: F. Rizzi, M. Bruno, M. Sacco, F. Maletta, S. Rizza, P. Cortegoso Valdivia, S. Gaia, M. Gesualdo, F. Cravero, C.G. De Angelis
Journal: Endoscopy (2022)

Aims In pancreatic neuroendocrine neoplasms (pNEN) prognosis and therapeutic choices are mostly influenced by histological grading (G), based on Ki67 proliferative index: a correct pre-surgical evaluation is fundamental. The aim of the study is to evaluate the agreement of Ki67 and the respective grading, between EUS-guided sampling (FNA/FNB) and surgical specimen, in patients with pNEN.
DOES ARTIFICIAL INTELLIGENCE ASSIST ENDOSCOPISTS TO EASIER DIAGNOSE GASTRIC PRECANCEROUS LESIONS AND HELICOBACTER-PYLORI INFECTION? A SYSTEMATIC-REVIEW AND META-ANALYSIS
Authors: E. Dilaghi, E. Lahner, B. Annibale, G. Esposito
Journal: Endoscopy (2022)

Aims The endoscopic diagnosis of Helicobacter-pylori(Hp) infection and gastric precancerous lesions(GPL), namely atrophic gastritis and intestinal metaplasia, remains still challenging. Artificial intelligence(AI) may represent a powerful resource for endoscopists, making the endoscopic recognition of these conditions easier. Our study aimed to explore the diagnostic-performance of AI in the endoscopic diagnosis of GPL and Hp infection using AI processed endoscopic images.
Prevention, treatment and care of substance use disorders in times of <scp>COVID</scp>‐19
Authors: Nora D. Volkow, Susan Maua, Giovanna Campello, Vladimir Poznyak, Dzmitry Krupchanka, Wataru Kashino, Anja Busse
Journal: World Psychiatry (2022)

Since 2015, the United Nations Office on Drugs and Crime (UNODC) – World Health Organization (WHO) Informal Scien­tific Network (ISN) has brought the voice of science to international drug policy discussions, especially at the Commission on Narcotic Drugs, the prime policy-making body of the United Nations (UN) for drug control matters. In recent years, the public health dimensions of the world drug problem, including prevention and treatment of substance use disorders (SUDs), have become prominent in policy debates within the UN system1. Individuals with SUDs are at increased risk of contracting COVID-19 and, if infected, are more likely to experience negative outcomes2-4. This vulnerability reflects both the adverse effects of the non-medical use of psychoactive substances on health5, compounded by high rates of non-attended medical comorbidities3, 4, as well as associated psychosocial and structural factors. These may include situations of homelessness and incarceration, which increase the risk of acquiring COVID-19 through intermediate and direct factors (e.g., poverty, stigma, overcrowded set­tings) and decrease access to adequate care, ultimately worsening outcomes6. Several surveys have identified disruptions of services for people with SUDs during the COVID-19 pandemic7. Providing services for population groups with increased vulnerabilities is a key public health principle especially during a pandemic, also benefitting the general population as a whole4. Evidence-based and human rights-based treatment of SUDs, including mental health and physical comorbidities, should be considered essential and integrated into existing health care services. The provision of remote services and digital health solutions for the treatment and care of SUDs, and medications to treat SUD and prevent overdose, should be accessible to those in need. Due to overlapping vulnerabilities, people who use substances with special treatment and care needs carry a disproportionate risk and require special attention8. Investment in evidence-based prevention and treatment of SUDs and comorbid health conditions, and attention to the impact of social determinants on the health of all age groups are now more necessary than ever. Global actions are needed to build health systems resilience for universal health coverage and health security during the COVID-19 pandemic and beyond9. The ISN recommends to ensure that, during and beyond the COVID-19 pandemic, people with drug use disorders are not left behind, and that quality substance use prevention, treatment and care services are accessible to those in need, including to those in most vulnerable circumstances.
ARTIFICIAL INTELLIGENCE IN (GASTROENTEROLOGY) HEALTHCARE – PATIENTS’ AND PHYSICIANS’ PERSPECTIVES
Authors: Q.E. van der Zander, M.C. van der Ende-van Loon, J.M. Janssen, B. Winkens, F. van der Sommen, A.A. Masclee, E.J. Schoon
Journal: Endoscopy (2022)

Aims Artificial intelligence (AI) is entering into daily life and has great potential in healthcare. Aim was to investigate the knowledge, experience, and opinion on AI among patients with gastrointestinal (GI) disorders and GI-physicians.
ENDOSCOPIC ULTRASOUND FINE-NEEDLE BIOPSY VERSUS FINE-NEEDLE ASPIRATION FOR TISSUE SAMPLING OF LYMPH NODES: A SYSTEMATIC REVIEW AND META-ANALYSIS​​​​​​​​
Authors: A. Facciorusso, S.F. Crinò, P. Gkolfakis, D. Ramai, A. Lisotti, I. Papanikolaou, B. Mangiavillano, K. Triantafyllou, P. Fusaroli
Journal: Endoscopy (2022)

Aims There is scarce evidence on the comparison between endoscopic ultrasound (EUS) fine-needle biopsy (FNB) and fine-needle aspiration (FNA) of lymph nodes (LNs). Aim of this meta-analysis was to compare the diagnostic performance of these two approaches.
RISK FACTORS FOR COLORECTAL POLYPS
Authors: A. Sair, A. Benhamdane, T. Addajou, M. Osman, S. Mrabti, R. Berraida, S. Sentissi, I. Elkoti, F. Rouibaa, A. Benkirane, H. Seddik
Journal: Endoscopy (2022)

Aims Colorectal polyps are the main precursor lesions of colorectal cancer (CRC). Detecting polyps is essential to reduce the incidence of CRC and the consequent morbi mortality.
AI-ASSISTED DETECTION, CHARACTERIZATION AND SIZING OF COLORECTAL POLYPS. CAN AI SUPPORT NON-EXPERT ENDOSCOPISTS TO ACHIEVE PIVI THRESHOLDS? INTERIM RESULTS FROM A PROSPECTIVE MULTI-CENTER INTERNATIONAL TRIAL
Authors: M. Abdelrahim, K. Takoh, T. Okuno, S. Goda, H. Htet, J. Hamson, S. Aslam, K. Siggens, A. Tanasescu, S. Sasidharan Nair, M. Elias, A. Salviato, S. Mohammed, A. Parra-Blanco, S. Ishaq, G. Antonelli, M. Fraile-López, M. Spadaccini, S. Subramaniam, G. Longcroft-Wheaton, A. Alkandari, C. Hassan, A. Repici, P. Bhandari
Journal: Endoscopy (2022)

Aims Real-time in-vivo characterization of colorectal polyps remains limited outside expert centers. Data on AI polyp detection and characterization is promising but accurate sizing remains the missing jigsaw piece. We aimed to study the impact of a novel AI system on non-expert endoscopists' detection, characterization and sizing of colorectal polyps compared to experts.
104P HELENA: Study of HER2-low as a prEdictive factor of response to Neoadjuvant chemotherapy in eArly breast cancer
Authors: F. Cherifi, A. Da Silva, A.C. Johnson, C. Blanc Fournier, A. Broyelle, O. Abramovici, A. Morel, M. Bertho, I. Hrab, D. Allouache, C. Segura Djezzer, C. Levy, C. Boscher, M. Villemin, P. Rottier, J. Lequesne, G. Emile
Journal: Annals of Oncology (2022)
ESD RESECTION OF COLRECTAL PEDUNCULATED POLYPS: FIRST RESULTS
Authors: J. Jakobs, P. Stathopoulos, M. Zumblick, C. Denkert, U. Denzer
Journal: Endoscopy (2022)

Aims Endoscopic conventional resection of pedunculated polyps is technically difficult in cases of large polyp and/or broad stalk. In particular, en bloc resection with conventional snare resection can be challenging in these cases. We evaluated the feasibility of ESD for large pedunculated polyps with wide stalks.
EFFICACY AND SAFETY OF TRANSMURAL EUS-GUIDED GALLBLADDER DRAINAGE: A META-REGRESSION ANALYSIS
Authors: C. Fabbri, C. Binda, M. Sbrancia, E. Dajti, C. Coluccio, G. Ercolani, A. Anderloni, A. Cucchetti
Journal: Endoscopy (2022)

Aims Transmural EUS- guided gallbladder drainage (EUS-GBD) has been increasingly used in the treatment of gallbladder diseases. Aims of the study were to provide a comprehensive meta-analysis and meta-regression of features and outcomes after this procedure.
PREDICTORS OF SEVERE ADVERSE EVENTS AFTER ENDOSCOPIC ULTRASOUND THROUGH-THE-NEEDLE BIOPSY OF PANCREATIC CYSTS: A MACHINE LEARNING APPROACH
Authors: A. Facciorusso, B. Kovacevic, D. Yang, F. Vilas-Boas, B. Martínez-Moreno, S. Stigliano, G. Rizzatti, M. Sacco, M. Arevalo-Mora, L. Villarreal-Sanchez, M.C. Conti Bellocchi, L. Bernardoni, A. Gabbrielli, L. Barresi, P. Gkolfakis, C. Robles-Medranda, C. De Angelis, A. Larghi, F.M. Di Matteo, J. Aparicio, G. Macedo, P. Draganov, P. Vilmann, A. Repici, S.F. Crinò
Journal: Endoscopy (2022)

Aims A non-negligible rate of severe adverse events (AEs) was observed with endoscopic ultrasound (EUS) through-the-needle biopsy (TTNB) of pancreatic cystic lesions (PCLs); however, predictive factors are still unknown. We aimed at identifying the hierarchic interaction among independent predictors for TTNB-related AEs and to generate a prognostic model using recursive partitioning analysis (RPA).
ENDOSCOPIC TREATMENT METHOD FOR SYMPTOMATIC THORACIC ESOPHAGEAL DIVERTICULUM
Authors: F. Aslan, A.B. Ak, K. Darcin
Journal: Endoscopy (2022)

A 71-year-old male patient presented to clinic with dysphagia and persistent cough. On his past medical history there were congestive heart failure(EF%29) and the pacemaker placement which required him to take antiaggregant-treatment. On esophagography imaging, a 6cm in diameter diverticulum in thoracic-esophagus was detected.On CT imaging, there was no pathology other than esophageal diverticulum was observed.Under general anesthesia, the patient was treated with endoscopic septomytomy and POEM at distal to the diverticulum until the distal end of the gastroesophageal junction using the tunnel technique. Afterwards, the tunnel entrance was closed with clips. Patient was discharged on postoperative day 2.
ASSESSMENT OF ADVANCED METHODS FOR DIFFICULT BILIARY CANNULATION
Authors: A. Steshenko, A. Klymenko, V. Klymenko, I. Molnar, A. Zakcharchuk, A. Kiosov, V. Tkachov
Journal: Endoscopy (2022)

Aims Our research aim to assess the effectiveness and safety of advanced methods for difficult biliary cannulation such as needle knife precut sphincterotomy, double guide wire technique, transpancreatic biliary sphincterotomy with pancreatic stent placement.
3D IMPEDANCE PLANIMETRY IMPROVES PERI-INTERVENTIONAL PROCEDURE IN ENDOSCOPIC THERAPY OF COMPLEX ESOPHAGEAL STENOSIS
Authors: N. Sturm, A. Kalner, M. Binzberger, M. Wagner, T. Seufferlein, B. Walter
Journal: Endoscopy (2022)

Aims Non-malignant strictures in the upper GI tract causing dysphagia have significant impact on QoL in patients. Esophageal dilation using fluoroscopic control is standard. Especially complex stenosis challenge the interventional endoscopist regarding size and tissue compliance. Tools to evaluate exact stenosis configuration without additional X-ray exposure are mandatory. 3D-planimetry could offer the possibility to estimate exact size, diameter and tissue resistance.
ENDOROTOR​: A NEW INSTRUMENT IN EMR
Authors: E. Álvarez Arroyo, J.F. Martínez Sempere, C. Mangas-Sanjuán, R. Jover Martínez, J.R. Aparicio Tormo
Journal: Endoscopy (2022)

We present the case of a 78 years old man who consults us because of chronic diarrhea. In the colonoscopy we find a 10cm LST-GH lesion in rectum, NICE 2, with low grade dysplasia in histology. Firstly we try to perform an endoscopic mucosal resection, which has to be interrupted because of the prolonged length of the procedure (6 hours). In a second attempt, the resection is difficulted due to the amount of fibrosis, so we decide to resect it with the EndoRotor system, achieving a complete removal of the lesion.
INDICATIONS AND DIAGNOSTIC YIELD OF SMALL BOWEL ENDOSCOPY: ANALYSIS OF A LARGE, REAL-WORLD, DATABASE FROM A TERTIARY REFERRAL CENTER IN GREECE
Authors: N. Viazis, F. Almpani, A. Mountaki, K. Koustenis, C. Veretanos, A. Tsatsa, A. Trikola, E. Beka, K. Arvanitis, T. Georgiadi, G. Karampekos, E. Vienna, E. Archavlis, M. Mela, A. Christidou, C. Chantzievangelinou, K. Katopodi, V. Papastergiou, G. Mantzaris
Journal: Endoscopy (2022)

Aims Small bowel capsule endoscopy (SBCE) is a valuable diagnostic tool used for a variety of clinical indications. Using a large database, we aimed at evaluating indications and diagnostic yield of SBCE in a real-world setting.