tbuckley/cabot-search huggingface dataset:
Rituximab Maintenance Versus Wait and Watch after Four Courses of R-DHAP Followed By Autologous Stem Cell transplantation in Previously Untreated Young Patients with Mantle Cell Lymphoma: First Interim Analysis of the Phase III Prospective Lyma Trial, a Lysa Study
Authors: Steven Le Gouill, Catherine Thieblemont, Lucie Oberic, Krimo Bouabdallah, Emmanuel Gyan, Gandhi Damaj, Vincent Ribrag, Serge Bologna, Remy Gressin, Olivier Casasnovas, Corinne Haioun, Philippe Solal-Celigny, Herve Maisonneuve, Eric Van Den Neste, Anne Moreau, Marie C Bene, Gilles Salles, Hervé Tilly, Thierry Lamy, Olivier Hermine
Journal: Blood (2014)
A CASE OF BACTEREMIA DUE TO AN UNIDENTIFIED GRAM-NEGATIVE PASTEURELLA-LIKE BACILLUS WITH RECOVERY FOLLOWING STREPTOMYCIN THERAPY
Authors: E APPELBAUM, M GELFAND
Journal: Annals of Internal Medicine (1947)

Case Reports1 May 1947A CASE OF BACTEREMIA DUE TO AN UNIDENTIFIED GRAM-NEGATIVE PASTEURELLA-LIKE BACILLUS WITH RECOVERY FOLLOWING STREPTOMYCIN THERAPYEMANUEL APPELBAUM, M.D., F.A.C.P., MAXWELL GELFAND, M.D.EMANUEL APPELBAUM, M.D., F.A.C.P.Search for more papers by this author, MAXWELL GELFAND, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-26-5-780 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecent reports have suggested that streptomycin is of therapeutic value in the treatment of diseases caused by a variety of gram-negative pathogens. Up to the present time, however, the total published clinical data on the use of this antibiotic agent are limited. It seems, therefore, worth while to record a case of bacteremia due to an unidentified gram-negative bacillus in which recovery appeared to follow the use of streptomycin.CASE REPORTHistory. A male, aged 29, was admitted to Bellevue Hospital on December 4, 1945, complaining of chills and fever of three weeks' duration. Five weeks prior to admission the...Bibliography1. REIMANNPRICEELIAS HAAHWF: Streptomycin for certain systemic infections and its effect on the urinary and fecal flora, Arch. Int. Med., 1945, lxxvi, 269-277. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication July 20, 1946.From the Fourth Medical (New York University) Division, Bellevue Hospital and the Bureau of Laboratories, New York City Health Department.†Streptomycin used in this case was kindly supplied by E. R. Squibb & Sons and by Charles Pfizer & Co. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPasteurella multocida BacteremiaInfective Endocarditis Caused by Fastidious Oro-Pharyngeal HACEK Micro-OrganismsSEPTICAEMIA CAUSED BY CARDIOBACTERIUM HOMINISInfective endocarditis caused by gram-negative bacteria: A review of the literature, 1945–1977Endocarditis Caused by Pasteurella MultocidaEndocarditis Caused by a Pasteurella-like OrganismStreptomycin in the Treatment of Subacute Bacterial EndocarditisStreptomycin in the Treatment of Bacterial Endocarditis 1 May 1947Volume 26, Issue 5Page: 780-783KeywordsAntibioticsBacillusBacteremiaFeversPathogensStreptomycin ePublished: 1 December 2008 Issue Published: 1 May 1947 PDF downloadLoading ...
Abstract 3112: High Incidence of Venous Thrombosis following Cardiac Surgery
Authors: Girish Mood, Heather L Gornik, Vidyasagar Kalahasti, Donald Hammer, Wilson W Tang
Journal: Circulation (2007)

Aim: The incidence of venous thrombosis (VT) after general or orthopedic surgical procedures is significantly elevated, generally requiring pharmacologic or mechanical VT prophylaxis. However, ther...
Abstract 17546: Effect of Intravenous Ferric Carboxymaltose on Symptoms and Quality of Life in Iron-Deficient Patients With Chronic Heart Failure With and Without Anemia: A Sub-Analysis of the FAIR-HF Trial
Authors: Gerasimos Filippatos, Josep Comin Colet, Kenneth Dickstein, Thomas Luscher, Ronnie Willenheimer, Claudio Mori, John Norrie, Ian Ford, Piotr Ponikowski, Stefan D Anker
Journal: Circulation (2010)

Background: Therapy with intravenous iron in patients with chronic heart failure (CHF) and iron deficiency improves symptoms, functional capacity and quality of life. We sought to investigate wheth...
Abstract 1965: Global Longitudinal Strain and Strain Rate Imaging for Assessment of Systemic Right Ventricular Function
Authors: Pak-cheong Chow, Xue-cun Liang, Wendy W Lam, Eddie W Cheung, Yiu-fai Cheung
Journal: Circulation (2007)

Background - We determined the usefulness of novel 2-dimensional strain indices, based on speckle tracking imaging, for assessment of systemic right ventricular (RV) function after atrial switch operation for transposition of the great arteries. Methods - Twenty-six patients, aged 21.0±3.6 years at 19.9±3.2 years after atrial switch operation, and 27 age-matched controls were studied. Two-dimensional imaging at the 4 chamber view was obtained with tracing of the entire RV endocardial border. The RV global longitudinal strain (GLS) and GLS rate were derived using an automated software (EchoPAC, GE Medical) (fig ), and correlated with tissue Doppler-derived RV isovolumic acceleration (IVA), and, in patient cohort, with cardiac magnetic resonance-derived RV ejection fraction. Results - Intraobserver and interobserver variability for measurement of GLS from 20 studies were 0.06±1.93% and 0.24±1.77% respectively. Compared with controls, patients had lower RV GLS (17.1±1.9% vs 26.3 ±2.9%, p&lt;0.001), reduced GLS rate (0.78 ±0.11/s vs 1.33 ±0.23/s, p &lt;0.001), lower RV IVA (1.10 ±0.36 m/s 2 vs 1.56 ±0.53 m/s 2 , p=0.001), and increased RV myocardial performance index (0.52±0.09 vs 0.38 ±0.09, p=0.001). Both RV GLS and GLS rate correlated positively with RV IVA (r=0.43, p&lt;0.001 and r=0.46, p&lt;0.001, respectively), and negatively with RV myocardial performance index (r=−0.65, p&lt;0.001 and r=−0.57, p&lt;0.001 respectively). In patients, GLS rate correlated positively with RV ejection fraction (r=0.62, p=0.001). Conclusion - Two-dimensional RV GLS and GLS rate are novel indices potentially useful for assessment of systemic RV function.
Changing practice in maternity care
Authors: M. J N C Keirse
Journal: BMJ (1998)

Papers p 1041 

The tenet that clinical practice should be guided by rigorous evidence has become so ingrained that clinicians who are slow on the uptake are seen as not aware of the evidence, bogged down by tradition, or—worse—having selfish motives for ignoring evidence. Rarely is the evidence itself questioned. Yet, if evidence were a straightforward concept, there would be no reason for the two disciplines that appear to be governed by it, law and medicine, to be at loggerheads so often.

The evidence available does not necessarily reveal what you are interested in for a particular situation. Thus many reviews in the CochraneLibrary , the gold standard of systematic reviews, devote no attention to adverse effects in assessing the effectiveness of health care interventions (Bastian H, Middleton P. Cochrane Colloquium,Amsterdam, 1997). Yet any intervention (be it advice, screening for disease,drugs, or surgery) that is likely to be beneficial for some people is also likely to harm others. Even if the evidence is clear on the effectiveness of an approach, it does not necessarily reveal how to pursue that approach.For example, systematic reviews may show …
The Melbourne Family Grief Study, II: Psychosocial morbidity and grief in bereaved families
Authors: D W Kissane, S Bloch, P Onghena, D P McKenzie, R D Snyder, D L Dowe
Journal: American Journal of Psychiatry (1996)

The aim of this study was to describe the intensity of grief, the psychosocial morbidity, and the coping patterns in members of families classified according to a typology of family functioning comprising supportive, conflict-resolving, intermediate, sullen, and hostile classes.One hundred fifteen families were assessed longitudinally 6 weeks (time 1), 6 months (time 2), and 13 months (time 3) after the death of a parent (constituting 670 individual responses) on measures of grief intensity, psychological state, social adjustment, and family coping. A previously described typology of perceptions of family functioning was applied. Repeated measures multivariate analysis of variance based on both individuals and families and post hoc comparisons of significant results were undertaken.Sullen families displayed the most intense grief and the most severe psychosocial morbidity. Well-functioning families (supportive and conflict-resolving) resolved their grief and adjusted more adaptively than their dysfunctional counterparts (intermediate, sullen, and hostile families). There were no cluster-by-time interactions. The clusters accounted for 15.7% of the variance in depression (Beck Depression Inventory) and 27.9% of the variance in social functioning (Social Adjustment Scale). Well-functioning families used more family coping strategies (Family Crisis Oriented Personal Evaluation Scales).More intense grief and greater psychosocial morbidity are found in sullen, hostile, and intermediate bereaved families than in the more adaptive supportive and conflict-resolving types. At-risk families are identifiable and could be treated preventively to reduce morbidity.
Thromboprophylaxis with low molecular weight heparin versus unfractionated heparin in intensive care patients: a systematic review with meta-analysis and trial sequential analysis
Authors: Sigrid Beitland, Irene Sandven, Lill-Kristin Kjærvik, Per Morten Sandset, Kjetil Sunde, Torsten Eken
Journal: Intensive Care Medicine (2015)
Abstract 15729: Subcellular Distribution of ATP-Sensitive K+ Channels in Ventricular Myocytes
Authors: Li Bao, Miyoun Hong, Monique Foster, Eirini Kefaloyianni, Mario Delmar, William Coetzee
Journal: Circulation (2012)

Ventricular ATP-sensitive potassium (KATP) channels link intracellular energy metabolism to membrane excitability and contractility. Our recent proteomics data identified ventricular cell end-to-en...
Use of ECT in California, 1977-1983
Authors: B A Kramer
Journal: American Journal of Psychiatry (1985)

The author examined the use of ECT in California from 1977 to 1983, a period during which its availability steadily declined. Approximately 1.12 persons per 10,000 population received ECT in 1977-1983, with little variation from year to year. Most ECT was paid for with nonpublic funds by white patients in nongovernmental facilities. The probability of receiving ECT increased with the age of the patient. ECT was quite safe: no fractures were reported, and the mortality rate was 0.2 deaths per 10,000 treatments. Despite restrictive regulation and limited availability, ECT continues to be used in California.
Phase I trial of an interleukin-2 (IL-2) fusion toxin (DAB486IL-2) in hematologic malignancies expressing the IL-2 receptor
Authors: CF LeMaistre, C Meneghetti, M Rosenblum, J Reuben, K Parker, J Shaw, A Deisseroth, T Woodworth, DR Parkinson
Journal: Blood (1992)
Abstract 5347: Alpha-Adrenergic-Regulation of I <sub>K1</sub> and Acetylcholine-gated I <sub>K,ACh</sub> is Impaired in Patients with Atrial Fibrillation
Authors: Niels Voigt, Birgit Bollmann, Erich Wettwer, Klaus Matschke, Ursula Ravens, Dobromir Dobrev
Journal: Circulation (2008)

In chronic atrial fibrillation (cAF) the major effector of vagal excitation I K,ACh develops arrhythmogenic ACh-independent constitutive activity with limited additional activation via muscarinic receptors. Since the sympathetic nervous system prevents excessive vagal nerve activation we tested whether modulation of I K,ACh by adrenoceptors (ARs) is affected in cAF. I K,ACh was measured with whole-cell voltage-clamp in isolated right atrial myocytes from 29 sinus rhythm (SR) and 17 cAF patients. Compared to SR basal current was higher in cAF whereas carbachol (CCh, 2 μM)-activated I K,ACh was smaller (Figure ). Activation of beta-ARs with isoproterenol (ISO, 1 μM) increased CCh-activated I K,ACh by ~25% and ~20% in SR and cAF, respectively, whereas activation of adenylyl cyclase with forskolin (FSK, 1 μM) was without effect suggesting channel activation by G-beta/gamma-binding rather than PKA. Stimulation of alpha-1-ARs with phenylephrine (PE, 100 μM) reduced CCh-activated I K,ACh in SR by ~80%, but was ineffective in cAF. Neomycin (NEO, 500 μM), a blocker of phospholipase-C (PLC), prevented the PE effect suggesting that PE blunts I K,ACh activation via PLC-induced depletion of membrane PIP2 content required for I K,ACh stimulation. PE, but not ISO or FSK, reduced basal current in SR by ~50%, suggesting inhibition of I K1 , but was ineffective on basal current in cAF which consists of I K1 and constitutively active I K,ACh . Inhibition of CCh-activated I K,ACh and suppression of I K1 by alpha-1-ARs are impaired in cAF. These changes may shift the balance to stronger beta-AR-mediated I K,ACh activation promoting the maintenance of AF.
Factors affecting the adherence to an antenatal screening programme: an experience with toxoplasmosis screening in France
Authors: C Cornu, A Bissery, C Malbos, R Garwig, C Cocherel, R Ecochard, F Peyron, M Wallon
Journal: Eurosurveillance (2009)

Monthly serological testing is mandatory in France for pregnant women not immune to toxoplasmosis. We assessed for the first time the adherence to this national programme, using data from antenatal tests for Toxoplasma antibodies collected by the Union of Health Insurance Services in the French Rhone-Alpes region.
Stubbed out
Authors: Des Spence
Journal: BMJ (2007)

I went to the launderette fortnightly. It wasn't that I had lots of clothes—I didn't. But a wet sponge and steam iron works wonders. As I ironed, the steam billowed from my PolymixPubJob shirt, carrying the sweet smell of stale beer and cigarettes. The final touch to my shirt was aftershave. In the 1980s this was all produced in Middlesbrough by ICI to a classified cold war formula—a tiny splash of Brut Musk could conceal weeks of unwashed clothes. To this day it still seeps from my pores when I sweat. But the modern bartender will soon be spared the need to wear cheap aftershave, for England is to ban smoking in confined public spaces.

The risks of smoking have been clear for many decades, but when I grew up in the 1970s smoking was common—vast ornamental ash trays and coffee table lighters were the order of the day. People puffed away in sitcoms and in Hollywood's blockbusters, and Formula One cars were cigarette packets on wheels. As an adult in the 1980s I smoked occasionally but regularly in a way that has become known as “social smoking”—on nights out and sometimes during the day. In the conformist sausage factory that is medicine it was my youthful (and stupid) act of defiance to stand outside the exam hall smoking one of those foreign brands that newsagents would sell only to card carrying students. The dire warnings printed on the packets were meaningless to risk obsessed youth. I am lucky, for I was able to resist the terrible pull into the tornado of addiction that smoking is.

But by middle age, life matters—I don't want to die. Half of all smokers die from their addiction, and on average smokers live 10 years less. But quitting is not easy. For me, smoking is bound to the extremes of my life—the good and the bad.

Smoking is pernicious. I have witnessed too many men and women in their 40s die from the many manifestations of vascular disease and seen others consumed by lung cancer. But worse still is the decades spent on an oxygen mask, confined to your home. Smoking has left great wounds slashed into the lives of children, husbands, wives with the needlessly and prematurely death of their loved ones. It is harder still for families to accept the injustice of the loss of a victim of secondhand smoking.

My attitude towards smokers remains passive. If smokers choose to smoke, then so be it. In the cockpit of life the control panel is jammed with self destruct buttons—smoking is merely one among many. Smoking is in terminal decline, and banning smoking in public is long overdue. Whether we do likewise with 1980 aftershaves is another issue.
Abstract 21279: A Randomised Controlled Trial Comparing Conventional Coronary Artery Bypass Graft Surgery with a Composite Arterial Graft Technique
Authors: Albert E Alahmar, Bashir Matata, Matthew Shaw, Raphael Perry, Rodney H Stables
Journal: Circulation (2010)

Background: Composite (Y/T) coronary artery bypass graft surgery (CABG) confers full arterial revascularisation, and “hands off” aorta compared to conventional bypass graft surgery. However, the co...
Wanted: a green NHS
Authors: Rachel C Stancliffe, Mahmood Bhutta
Journal: BMJ (2008)

We welcome the BMJ ’s latest issue on climate change (26 January), which suggests some strategies for health professionals in response to global warming, including adaptation and surveillance and forecasting of health risks.1

“Climate change: what can doctors do?” asks the BMJ ’scover. We believe that doctors must do more than respond to the crisis …
Biologic response of B lymphoma cells to anti-CD20 monoclonal antibody rituximab in vitro: CD55 and CD59 regulate complement-mediated cell lysis
Authors: Josée Golay, Luisella Zaffaroni, Thomas Vaccari, Manuela Lazzari, Gian-Maria Borleri, Sergio Bernasconi, Francesco Tedesco, Alessandro Rambaldi, Martino Introna
Journal: Blood (2000)
Inability to reason statistically is prime cause of lottery fever
Authors: R. Persaud
Journal: BMJ (1995)

EDITOR,--In their editorial Martin McKee and Franco Sassi express concerns about the public health consequences of the National Lottery, particularly in relation to its encouragement of gambling, redistributive wealth effects, and implications for donations to medical charities.1 Several important points, however, are neglected. Firstly, the forces driving the spread of lotteries may be more powerful than the authors realise: in the United States, state lottery …
Progress Toward Regional Measles Elimination — Worldwide, 2000–2017
Authors: Alya Dabbagh, Rebecca L. Laws, Claudia Steulet, Laure Dumolard, Mick N. Mulders, Katrina Kretsinger, James P. Alexander, Paul A. Rota, James L. Goodson
Journal: MMWR Morbidity and Mortality Weekly Report (2018)

In 2010, the World Health Assembly set three milestones for measles prevention to be achieved by 2015: 1) increase routine coverage with the first dose of measles-containing vaccine (MCV1) among children aged 1 year to ≥90% at the national level and to ≥80% in every district; 2) reduce global annual measles incidence to less than five cases per million population; and 3) reduce global measles mortality by 95% from the 2000 estimate (1).* In 2012, the World Health Assembly endorsed the Global Vaccine Action Plan (GVAP),† with the objective of eliminating measles§ in four of the six World Health Organization (WHO) regions by 2015 and in five regions by 2020. Countries in all six WHO regions have adopted goals for measles elimination by 2020. This report describes progress toward global measles control milestones and regional measles elimination goals during 2000-2017 and updates a previous report (2). During 2000-2017, estimated MCV1 coverage increased globally from 72% to 85%; annual reported measles incidence decreased 83%, from 145 to 25 cases per million population; and annual estimated measles deaths decreased 80%, from 545,174 to 109,638. During this period, measles vaccination prevented an estimated 21.1 million deaths. However, measles elimination milestones have not been met, and three regions are experiencing a large measles resurgence. To make further progress, case-based surveillance needs to be strengthened, and coverage with MCV1 and the second dose of measles-containing vaccine (MCV2) needs to increase; in addition, it will be important to maintain political commitment and ensure substantial, sustained investments to achieve global and regional measles elimination goals.
Sexual function and affect in parkinsonian men treated with L-dopa
Authors: E Brown, G M Brown, O Kofman, B Quarrington
Journal: American Journal of Psychiatry (1978)

Using psychiatric interviews, sexual and affect rating scales, hormonal studies, and neurologic assessment, the authors assessed the effect of L-dopa treatment on men with Parkinson's disease. Patients demonstrated variable affect changes. Approximately one-half of the patients reported an increased sexual interest that was not related to improvement in locomotor function. Hormonal factors appeared to be involved. The findings suggest that male parkinsonian patients who possess an intact hypothalamic-pituitary-gonadal axis experience increased sexual function related to L-dopa treatment.
Tobacco control in developing countries
Authors: Merete Osler
Journal: BMJ (2001)

Eds Prabhat Jha, Frank Chaloupka 

Oxford University Press, £32.50, pp 489

ISBN 0 19 263246 9

Rating: ![Graphic][1] ![Graphic][2] ![Graphic][3] 

In the past two decades the prevalence of smoking has risen in most low income and middle income countries, while it has declined in high income countries. Today, eight out of 10 of the world's 1.1 billion smokers live in low and middle income countries. It is therefore likely that the number of tobacco deaths will increase from four million to 10 million a year worldwide in the next 30 years. The vast majority …

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Combination therapy of nitrates and spironolactone in experimental portal hypertension
Authors: M VANDECASTEELE
Journal: Hepatology (1995)

To systematically evaluate the accuracy of free hepatic vein pressure (FHVP), the internal reference for hepatic venous pressure gradient (HVPG).Diameter and pressure measurements were obtained in multiple locations within the hepatic vein, inferior vena cava (IVC), and right atrium on 30 hepatic venograms in 29 consecutive candidates for transjugular intrahepatic portosystemic shunt creation.On angiography, 15 patients (52%) had hepatic veins showing a normal and conical appearance, whereas the other 14 had irregular or narrow (maximal diameter ≤ 6 mm) veins. Diameters of hepatic veins increased from 4.4 mm ± 0.9 (range, 3.3–7 mm) at a peripheral position to 8.7 mm ± 3.0 (range, 5.0–15.5 mm; P < .001) at a central position, and respective pressures decreased from 10.9 mm Hg ± 3.7 (range, 3–17 mm Hg) to 7.4 mm Hg ± 3.7 (range, 0–14 mm Hg; P < .001). Gradients between wedged hepatic vein pressure and central free hepatic vein, IVC, and right atrium pressures were 17.2 mm Hg ± 5.4 (range, 4–33 mm Hg), 18.0 mm Hg ± 5.8 (range, 4–33 mm Hg), and 20.0 mm Hg ± 5.9 (range, 4–33 mm Hg), respectively. Pearson correlation coefficients were 0.679 between the HVPG and hepatic atrial pressure gradient (HAPG) and 0.889 between the wedged hepatic vein/IVC pressure gradient (HCPG) and HAPG.FHVP measurement depends on catheter tip position and vein morphology. Its use to calculate HVPG is not recommended. The high agreement between the HCPG and the HAPG suggests that both gradients may be used if one considers a systemic difference of 2 mm Hg.
Treatment in general practice can be successful
Authors: C. Ford, B. Whitehead
Journal: BMJ (1996)

not injected and is a good alternative to injectable methadone.In detoxification it seems much easier to reduce.Rather than suggesting that the treatment of drug use should be a single strand management package-the use of oral methadone in a restricted and supervised manner-it would be useful to point out the many complex issues relating to drug dependence, which require exploration and constant innovation, evaluation, and modification of policies.