tbuckley/cabot-search huggingface dataset:
Health Personnel Still Not Receiving Flu Vaccine
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prolonged Weakness and Vecuronium
Authors: Yizhak Kupfer
Journal: Annals of Internal Medicine (1993)

Letters1 April 1993Prolonged Weakness and VecuroniumYizhak Kupfer, MD, Tatsuji Namba, MD, and Sidney Tessler, MDYizhak Kupfer, MDSearch for more papers by this author, Tatsuji Namba, MDSearch for more papers by this author, and Sidney Tessler, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-7-199304010-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:In response to Drs. Bernstein and Scott and colleagues, only the lowest dose of vecuronium required to prevent patient ventilator dyssynchrony was used. Neuromuscular blockade was discontinued at least twice daily to assess neurologic function and the continued need for paralysis. The dosage of vecuronium required to support long-term mechanical ventilation must be individually titrated. Patients with hepatic or renal insufficiency may require lower doses because of accumulation both of vecuronium and its 3-desacetylvecuronium metabolite. Such patients were excluded from our study. Tolerance, however, has been reported with prolonged use [1] with doses of vecuronium as high as ...References1. Coursin DB, Klasek G, Goelzer SL. Increased requirements to continuously infused vecuronium in critically ill patients. Anesth Analg. 1989; 69:518-21. Google Scholar2. Op de Coul AA, Lambregts PC, Koeman J, et al. Neuromuscular complications in patients given Pavulon (pancuronium bromide) during artificial ventilation. Clin Neurol Neurosurg. 1980; 87:17-22. Google Scholar3. Donati F, Meistelman C, Plaud B. Vecuronium neuromuscular blockade at the diaphragm, orbicularis oculi and adduction pollicus muscles. Can J Anaesth. 1990; 37:S13. Google Scholar4. Danon MJ, Carpenter S. Myopathy with thick filament (myosin) loss following prolonged paralysis with vecuronium during steroid treatment. Muscle Nerve. 1991; 14:1131-9. Google Scholar5. Hirano M, Ott BR, Raps EC, Minetti C, Lennihan L, Libbey NP, et al. Acute quadriplegic myopathy: a complication of treatment with steroids, nondepolarizing blocking agents, or both. Neurology. 1992; 42:2032-7. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1993Volume 118, Issue 7Page: 569-571KeywordsAction potentialsCreatine kinaseElectromyographyMusclesNervesNeuromuscular blockadeNeuropathyParalysisSteroidsVentilators ePublished: 15 August 2000 Issue Published: 1 April 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
RARE TUMORS
Authors: C. Kiyotani, T. Uno, H. Ogiwara, N. Morota, A. Nakazawa, Y. Tsutsumi, H. Masaki, T. Mori, J. A. S. Sanz, M. Guibelalde, A. Tavera, I. Herandez, J. Ibanez, M. Brell, A. Mas, H. L. Muller, U. Gebhardt, M. Warmuth-Metz, T. Pietsch, N. Sorensen, R.-D. Kortmann, S. Stapleton, I. Gonzalez, S. Steinbrueck, L. Rodriguez, G. Tuite, M. Krzyzankova, S. Mertsch, A. Jeibmann, U. Kordes, J. Wolff, W. Paulus, M. Hasselblatt, Y. Nonaka, S. Hara, S. Fukazawa, K. Shimizu, M. Ben-Arush, S. Postovsky, H. Toledano, M. Peretz-Nahum, J. Fujimura, S. Sakaguchi, A. Kondo, Y. Saito, K. Shimoji, Y. Ohara, A. Arakawa, M. Saito, T. Shimizu, M. Benesch, A. O. von Bueren, T. Dantonello, K. von Hoff, T. Pietsch, I. Leuschner, A. Claviez, U. Bierbach, G. Kropshofer, R. Korinthenberg, N. Graf, M. Suttorp, R. D. Kortmann, C. Friedrich, T. Klingebiel, E. Koscielniak, S. Rutkowski, M. Mesa, M. Sanchez, J. Mejia, G. Pena, R. Dussan, M. Cabeza, A. Storino, F. Dincer, T. Roffidal, M. Powell, S. Berrak, J. E. Wolff, F. Fouyssac, C. Delaunay, J.-M. Vignaud, E. Schmitt, O. Klein, L. Mansuy, P. Chastagner, O. Cruz, A. Guillen, G. Garcia, M. Alamar, S. Candela, I. Roussos, M. Garzon, M. Sunol, J. Muchart, M. Rebollo, J. Mora, J. Wolff, B. Diez, A. Muggeri, N. Arakaki, F. Meli, G. Sevlever, V. Tsitouras, B. Pettorini, G. Fellows, J. Blair, M. Didi, C. Daousi, C. Steele, M. Javadpour, A. Sinha, M. Hishii, A. Kondo, J. Fujimura, S. Sakaguchi, H. Ishii, K. Shimoji, M. Miyajima, H. Arai, R. Dvir, D. Sayar, D. Levin, L. Ben-Sirah, S. Constantini, R. Elhasid, E. Gertsch, N. Foreman, E. T. Valera, M. S. Brassesco, H. R. Machado, R. S. Oliveira, A. C. Santos, V. C. Terra, M. V. Barros, C. A. Scrideli, L. G. Tone, D. Merino, M. Pienkowska, A. Shlien, U. Tabori, R. Gilbertson, D. Malkin, I. Jeeva, B. Chang, V. Long, S. Picton, D. Burton, S. Clark, C. Kwok, B. Mokete, O. Rafiq, I. Simmons, M. M. K. Shing, C. K. Li, G. C. F. Chan, S. Y. Ha, H. L. Yuen, C. W. Luk, C. K. Li, S. C. Ling, R. C. H. Li, J. H. Yoon, H. J. Park, H. J. Shin, B.-K. Park, J.-Y. Kim, H. L. Jung, Y. S. Ra, T. T. Ghim, J. Wolff, M. Hasselblatt, S. Hartung, M. Powell, M. Garami, H. Traunecker, P. Thall, A. Mahajan, U. Kordes, D. Sumerauer, P. Grillner, A. Orrego, M. Mosskin, B. Gustavsson, S. Holm, N. Peters, M. Rogers, S. Chowdry, W. Selman, A. Mitchell, B. Bangert, S. Ahuja, K. Laschinger, D. Gold, D. Stearns, K. Wright, K. Gupta, P. Klimo, D. Ellison, G. Keating, L. Eckel, C. Giannini, N. Wetjen, A. Patton, W. Zaky, G. McComb, J. Finlay, J. Grimm, K. Wong, G. Dhall, W. Zaky, F. Gilles, J. Grimm, G. Dhall, J. Finlay, D. Ormandy, R. Alston, E. Estlin, R. Gattamaneni, J. Birch, I. Kamaly-Asl, M. Hemenway, N. Foreman, S. Rush, Y. A. Reginald, G. Nicolin, U. Bartel, J. R. Buncic, D. Aguilera, R. Flamini, C. Mazewski, M. Schniederjan, L. Hayes, W. Boydston, T. MacDonald, A. Fleming, N. Jabado, C. Saint-Martin, S. Albrecht, D. A. Ramsay, J. P. Farmer, A. Bendel, M. Hansen, S. Dugan, N. Mendelsohn
Journal: Neuro-Oncology (2012)
Unnecessary Surgery
Authors: William R. Barclay
Journal: JAMA (1976)

Physicians have a responsibility to advise, prescribe, and perform only that which is in the best interest of their patients. To subject a patient to a procedure that the physician believed to be of no benefit and that might even result in harm would be reprehensible. Most physicians are highly ethical people and try to use their best judgment and their clinical skills for the benefit of and not harm to their patients. Recently the Subcommittee on Oversight and Investigations of the Committee on Interstate and Foreign Commerce of the US House of Representatives held hearings on the subject of "unnecessary surgery." The report of the Committee, entitled "Cost and Quality of Health Care: Unnecessary Surgery," alleges that 2.38 million unnecessary operations performed in the United States in 1974 resulted in 11,900 deaths and an expenditure of 3.92 billion dollars. These are serious charges and should not be made without
1,1-Dichloroethylene: An Apoptotic Hepatotoxin?
Authors: Edward S. Reynolds, Mary Faggard Kanz, Pasquale Chieco, Mary Treinen Moslen
Journal: Environmental Health Perspectives (1984)

Within 2 hr after 1,1-dichloroethylene administration, the following phenomena occur in livers of fasted rats: dilation and disruption of bile canaliculi, plasma membrane invagination and loss of microvilli, cytoplasmic vacuolation, and loss of density in mitochondrial matrices. Early, selective loss of enzyme activities was localized by histochemical staining to bile canalicular, and inner and outer mitochondrial membranes. Biliary permeability to inulin increased, a change suggestive of the breakdown of junctions between hepatocytes. Endoplasmic reticulum and lysosomes appeared spared. In addition, scattered, individual hepatocytes exhibited changes characteristic of apoptosis by 2 hr: chromatin aggregation and margination, nucleolar coarse granulation and enlargement, rounded blebs and proturberances on cell surfaces, and the separation of these cells from surrounding parenchyma. In contrast, evidence of plasma membrane leakiness to K+, Ca2+ and soluble cytoplasmic enzymes was not detected until after 2 hr. Based on these observations, we propose that 1,1-dichloroethylene may initiate apoptosis-like cell degradation in selected parenchymal cells prior to or coincident with centrolobular necrosis.
Annales Chirurgiae et Gynaec Fenniae, Helsinki
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GYNECOLOGY
Authors: John W. Huffman
Journal: JAMA (1965)

A survey of books on gynecology should emphasize significant new texts. But any such survey would be incomplete if it did not indicate the recent editions of some of the older works and mention a few of those on subjects related to gynecology. <h3>Textbooks</h3> The<i>Textbook of Gynecology</i>(L. Parsons and S. E. Sommers, Saunders, 1962, $20) is the only new general work limited to gynecology which has appeared during the past four years. The authors, one a gynecologist and the other a pathologist, have produced a readable and comprehensive coverage of their subject. The question and answer method which they use in presenting their material is awkward at times. Some readers will be disturbed by the unnecessary duplication of subject matter which adds to the volume's size. It will not compete with the less cumbersome older textbooks intended for student use but will appeal to residents and practicing gynecologists.
Pericardial and Epicardial Disease in <i>Circulation</i> and the <i>Circulation</i> Subspecialty Journals
Journal: Circulation (2012)

The following articles are being highlighted as part of Circulation's Topic Review series. This series will summarize the most important manuscripts, as selected by the editors, published in Circulation and the Circulation subspecialty journals. The studies included in this article represent the articles related to pericardial and epicardial disease that were published in Circulation and the Circulation subspecialty journals in 2010 and 2011.
Obituaries
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SURGERY OF THE LUNG.
Authors: J. B. MURPHY
Journal: JAMA (1898)

<h3>Mr. President and Members of the American Medical Association:</h3> —Permit me to express my appreciation of the great honor conferred on me when elected to deliver the Annual Address on Surgery to this distinguished body of scientists. Custom has ordained that the address in the specialties of medicine at our annual convocation should be confined to a review of the advancements of the science and art of this branch in general in the preceding year. I take the liberty of deviating a little from this precedent to review the efforts and achievements made in a special and, until the last two decades, neglected field of surgery. I believe I am justified in this digression, as at the last, our semi-centennial convention, my predecessor enumerated and so emphasized the achievements of surgery for the last half century that I fear the consideration of a year's progress would be of small interest.
Drug Fever
Authors: J. REDON
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 August 1987Drug FeverJ. REDON, M.D., J. M. PASCUAL, M.D., J. MICHAVILA, M.D., A. BELDA, M.D.J. REDON, M.D.Search for more papers by this author, J. M. PASCUAL, M.D.Search for more papers by this author, J. MICHAVILA, M.D.Search for more papers by this author, A. BELDA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-2-264_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Drug fever is an underdiagnosed situation in part due to nonspecific clinical characteristics as reported by Mackowiak and LeMaistre (1). They wrote that ". . . any drug has the capacity to induce fever. . . . the list is a dynamic one. . . ." We have seen fever as the sole feature of adverse drug reaction by another two drugs not listed by them, (+)-cyanidanol-3 and azathioprine.(+)-Cyanidanol-3 is a flavonoid used to treat chronic liver disease (2), which induces fever, probably by an immunologic mechanism (3). We have previously reported (4) two men with...References1. MACKOWIAKLEMAISTRE PC. Drug fever: a critical appraisal of conventional concepts. Ann Intern Med. 1987;106:728-33. LinkGoogle Scholar2. (+)-cianidanol-3. Lancet. 1982;2:549. Google Scholar3. BRATTIGDIAGBERG NGP. (+)-Cianidanol-3-induced fever and its pathogenesis. In: CONN HO, ed. (+)-Cianidanol-3 in Diseases of the Liver: International Workshop. London: Royal Society of Medicine International Congress and Symposium Series; 1981:227-33. Google Scholar4. REDONPINAPASCUALCARMENABERENGUERCABALLERO JRJJJM. [Fever induced by (+)-cyanidanol-3]. Med Clin (Barc). 1983;81:784. MedlineGoogle Scholar5. KINGLAVERFAIRLEYAMES JMKG. Sensitivity to azathioprine. Med J Aust. 1972;2:939-41. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDrug-related fever due to cephazolin: A case reportAzathioprine hypersensitivity-like reations-a case report and a review of the literatureAssociation of fever, nasal congestion and rise in serum creatinine with azathioprine therapy 1 August 1987Volume 107, Issue 2Page: 264-264KeywordsAdverse reactionsChronic liver diseaseDrugsFeversFlavonoid Issue Published: 1 August 1987 PDF DownloadLoading ...
Limb salvage surgery for sarcomas: a good idea receives formal blessing
Authors: R. S. Benjamin
Journal: JAMA (1985)

Elsewhere in this issue of<i>JAMA</i>is a consensus development conference statement entitled "Limb-Sparing Treatment of Adult Soft-Tissue Sarcomas and Osteosarcomas,"1 prepared by a panel of 14 "drawn from the medical professions and the general public." As might be expected from the fact that every major center specializing in sarcoma treatment is already actively carrying out limb salvage surgery, the panel recommends its use in appropriately selected patients with sarcomas of soft tissue and bone. Obviously, any attempt at limb salvage surgery must not sacrifice the chances of cure, and there are some patients whose tumor size and/or location unfortunately prohibits adequate resection without sacrificing the extremity. Luckily, among those who have achieved full growth, such patients are in the minority. The benefits of limb salvage surgery are so obvious that one might question the rationale for convening such a panel in the first place, and so the organizers broadened
GC-04 * PRELIMINARY RESULTS OF A FEASIBILITY PILOT STUDY OF "GEMPOX" (GEMCITABINE, OXALIPLATIN, AND PACLITAXEL) IN PEDIATRIC AND ADULT PATIENTS WITH REFRACTORY OR RECURRENT CENTRAL NERVOUS SYSTEM (CNS) GERM CELL TUMORS (GCT): THE INTERNATIONAL CNS GCT CONSORTIUM TRIAL, CNS GCT- 4
Authors: J. Finlay, K. Haley, G. Dhall, D. Osorio, S. Gardner, J. Allen, J. Leonard
Journal: Neuro-Oncology (2015)
Intravenous beta agonist in severe acute asthma.
Journal: BMJ (1988)

Study objective-To determine whether sal- butamol is more effective in treating severe asthma when given intravenously or by inhalation.Design-Randomised trial of short term response to intravenous versus nebulised salbutamol in acute severe asthma.Setting-District general hospital (secondary care centre).Participants-76 patients aged 16-70 admitted to hospital with acute severe asthma (peak expiratory flow rate <50% of predicted) during study period.Five withdrawn because of adverse effects of treatment or non-response.Of remaining 71, 34 allocated to nebuliser group and 37 to intravenous treatment group.Patients with history of cardiovascular disease or recent corticosteroid or intra- venous bronchodilator treatment excluded.Admis- sion characteristics similar in the two groups.Interventions-All patients given 5 mg nebulised salbutamol on admission before randomisation plus 200 mg hydrocortisone bolus intravenously and 35% inspired oxygen throughout.Nebuliser group received two more 5 mg doses of nebulised salbuta- mol at 30 minutes and 2 hours; intravenous group received 4 hours' continuous salbutamol infusion (12 itg/min) starting at 30 minutes plus supple- mentary intravenous potassium chloride.No other bronchodilators used.Endpoint-Change in peak expiratory flow rate over 4 hours.Measurements and main results-Peak expiratory flow rate improved more in intravenous group (25-2%) than in nebuliser group (14-3%) (p<0-01, 95% confidence interval 2-4 to 19.1%).Tachycardia caused two withdrawals from intravenous group; non-response caused three withdrawals from nebuliser group.Conclusions-Intravenous salbutamol is more effective than nebulised salbutamol in acute severe asthma but may have unacceptable cardiovascular effects.
Transfusion, Philadelphia
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Retrospective Notes on Out-patient Practice
Authors: C. M. Durrant
Journal: BMJ (1865)

The circulation was not much impeded, except during the two last paroxysms.The pationt, however, evi- dently died asphyxiated, as the heart's action was vigorous only a few minutes before death.The only treatment adopted was the administra.tion of enemata and stimulants.The results of an enema proved the evacuations to be normal; and, from the rapid progress of the case, stimulants could not be administered to any extent.The cause of the gangrene is still an undecided point; that is, whether it was the ordinary gangrwna senilis, or specially induced by the exhausted condi- tion of the patient, or by exposuire during the night when excited and sleepless.Her age points to the first as the probable cause.The slough was confined to the lower surfaces and about one-half of the inner side of the toe.It was dry in its character, and mightpossiblyhave been unobserved bythe attendant.It is, at the same time, however, to be kept in view that, especially during the first week of the pa- tient's residence, she was restless, and occasionally out of bed, although the night-book does not show this to any great extent, and the night-watch had special instructions to visit her hourly.It remains a question, therefore, whether such exposure, if it existed, was the cause, as is often asserted, of this formidable though happily rare disease.RETROSPECTIVE1 NOTES ON OUT- PATIENT PRACTICE.
Methadone overdose treated with naloxone infusion
Authors: V. D. Waldron
Journal: JAMA (1973)

After methadone overdosage, toxic effects may persist for 24 hours. Therapeutic levels of naloxone hydrochloride are more evanescent after single injection. Accordingly, slow, constant infusion of the drug would seem the preferred treatment of methadone overdose. A case is reported in which that method was used successfully.