tbuckley/cabot-search huggingface dataset:
Pulmonary Asbestosis
Authors: W. E. Cooke
Journal: BMJ (1927)

published a short note on the woman who is the subject of this paper.The only similar case on record was that of a man admitted to the Charing Cross Hospital in 1899, whlere he died in 1900.Dr. E. L. Middleton of the Home Office kindly lent the notes of the case, and of tlhe evidence given before the Departmental Committee on Inldustrial Diseases in 1906 by the late Dr. H. Montague Muirray, under whose care the man had been.This patient, a man aged 33 years, had worked in the carding room of an asbestos factory for ten years prior to his admission to hospital.He informed Dr. Murray that he was the sole survivor of ten men who started work with him in the cardinig rooim; the othlers had died, presumably as the result of their occulpation.A post-mortem examination was held and the-diagnosis of pulmonary fibrosis was confirmed.Dr. Murray in his evidence refers to photomicrograplis of lung sections whichl show " spicules of asbestos."These are the salient facts of the first and, down to 1924, the only record of a death due to asbestos.
The extent of nephrectomy for renal cell cancer
Authors: H. Grabstald
Journal: JAMA (1968)

The ideal objective of any surgical program is cure. This communication will not concern itself with the circumstances in which nephrectomy may be palliative in patients with renal cell cancer. That ablative surgery may have value in the palliation of some symptoms, such as pain and fever, and in the cure of others, such as hematuria, is known. Only problems relating to surgical efforts to remove all local cancer in anticipation of cure will be reviewed. Any judicious decision regarding management of patients with renal cell cancer entails a knowledge of the natural history of the untreated tumor (which includes modes and rate of spread) and of the risks and the advantages of therapeutic alternatives. For example, if all renal cell cancers metastasized only by blood stream, there would be no reason for node dissection, and if there were no possibility of invasion of perirenal fat and fascia, simple nephrectomy
Instructional Course Lectures
Authors: James L. Hughes
Journal: JAMA (1972)

This volume is a compilation of selected lectures given at the annual meeting of the American Academy of Orthopaedic Surgeons during 1970. The editors are to be congratulated on assembling topics that are timely, as well as practical, in their clinical application. All subjects are covered in satisfactory detail and have a "just right" number of references for those who want to delve deeper. The book, essential for all persons associated with the field of orthopedics, forms the current standard of reference for many entities, such as lower-extremity bracing. While most physicians might find this topic cumbersome and unrewarding, the volume has much to offer in other areas. The orthopedists at the Lahey Clinic thoroughly survey the common problems concerning the shoulder. In this chapter a classification of shoulder pain is offered which is simple and practical. Appropriate attention is paid to the anatomy of the shoulder, as well as
Abstract 307: The Value of Intracranial Pressure Measurement via Lumbar Puncture as an Early Prognostic Predictor in Cardiac Arrest Patients Treated With Targeted Temperature Management
Authors: Yeonho You, Jung Soo Park, Jin Hong Min
Journal: Circulation (2018)

Introduction: We evaluated prognostic value of ICP measurement via lumbar puncture to predict outcome of cardiac arrest patients treated with TTM Methods: This was a single-center observational cohort study using paper sheets of patients from October 2012 to June 2017. The primary endpoint was the ability of the early ICP measurement to predict poor outcome within 24 h after cardiac arrest, compared to ONSD and GWR. Based on previous studies, 32 patients were needed to achieve the power of 0.90 at a significance level of 0.05. The ROC curves was used to compare the values of ONSD, GWR and ICP for predicting neurologic outcomes. Results were considered significant at P &lt; 0.05. Results: 103 patients were enrolled and good outcome group had 31 patients, while poor outcome group had 72 patients. The AUROC of ONSD and GWR were 0.64(0.54-0.73) and 0.63 (0.53-0.72) respectively in predicting poor neurologic outcome while the AUROC of ICP was 0.97(0.92-0.99) in predicting poor neurologic outcome (Fig. 2). As the cut off value of ICP was 200 mmH 2 O, sensitivity was 87.50% and specificity was 100.00% in predicting poor neurologic outcome. In ONSD, sensitivity was 78.43% and specificity was 41.86% in predicting poor neurologic outcome when cut off value was 5.50 mm. As the cut off value of GWR was 1.16, sensitivity was 59.72% and specificity was 74.19% in predicting poor neurologic outcome. Conclusion: In this study, we confirms that ICP measurement via lumbar puncture within the first 24 h after cardiac arrest is a valuable tool to evaluate the severity of post-cardiac arrest brain injuries and outcome in patients treated with TTM.
Neues für den praktischen Hals-, Nasen-, Ohrenarzt.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Characterizing molecular subtypes of high-risk nonmuscle-invasive bladder cancer in African American patients.
Authors: Stephen B. Williams, Sungyong You, Minhyung Kim, Steven G. Widen, Alexander Yu, Eduardo J. Eyzaguirre, Lars Dyrskjøt, David McConkey, Woonyoung Choi, Dan Theodorescu, Keith S. Chan, Yong Shan, Douglas S. Tyler, Amanda M. De Hoedt, Stephen J. Freedland
Journal: Journal of Clinical Oncology (2022)

527 Background: Patients with high-risk non-muscle-invasive bladder cancer (NMIBC) have heterogeneous outcomes with African Americans (AAs) having worse survival than European Americans (EAs). It is unknown whether race-based biological differences contribute to this disparity. Methods: We performed a retrospective cohort study including patients from the University of Texas Medical Branch (UTMB) and the Durham VA Health Care System (DVAHCS) from 2010-2020 among treatment naïve, high-risk NMIBC. Profiled gene expressions of high-risk NMIBC by race were performed using the UROMOL classification system. Results: A total of 26 patients (14 AAs and 12 EAs) matched on age and sex were included with no significant difference in clinical stage group (CIS +/- T1 or TaHG vs. TaHG or T1, no CIS), smoking status, or progression. We found a similar racial UROMOL subtype distribution with class 2a being most common. A total of 10 genes were discovered to be commonly upregulated differentially expressed genes (up-DEGs) in AAs vs EAs. EFEMP1, which has been associated with progression to muscle-invasive bladder cancer (MIBC) in vitro, and S100A16 gene expression, which has been implicated with mitomycin C resistance in bladder cancer in vitro, was significantly more common among AAs. We used single nuclei analysis to map the malignant cell heterogeneity in urothelial cancer which five distinct malignant epithelial subtypes whose presence has been associated with different therapeutic response prediction ability. We mapped the expression of the 10 genes commonly up-DEGs by race as a function of the five malignant subtypes. This showed borderline (p = 0.056) differences among the subtypes suggesting AA and EA patients may be expected to have different therapeutic responses to treatments for BC. AAs were enriched with immune-related, inflammatory, and cellular regulation pathways compared to EAs, yet appeared to have reduced levels of the aggressive C3 bladder tumor cell population. Conclusions: In this small sample, we found similar subtype distribution among high-risk NMIBC patients according to race. However, gene expression differs by race, supporting potential novel race-based etiologies for differences in muscle-invasion, response to treatments, and transcriptome pathway regulations. Further biological studies in NMIBC molecular sub-stratification, associated treatment(s), and prognoses in a larger cohort are needed to support these hypotheses.
MOTOR NOTES FOR MEDICAL MEN
Authors: H. M. Buist
Journal: BMJ (1916)

I-n -0-elardJakang TAhe tst a c-Sa reented ty traeo, J, '2, 3, 4., and infense hias been-used.At present it is inmpossible to construct a better scale, as tle -colours of comparative solutions of known strengtlh of T.N.T. vary so rapidly, and as thie substance so isolated from thc tirine does not belhave exactly like T.
VERONAL DERMATITIS.
Authors: PAUL G. WOOLLEY
Journal: JAMA (1907)

The occasional notices of the bad effects of veronal, and more especially of the ability of that drug to give rise to cutaneous symptoms, encourages me to relate my own experiences with it. Somewhat more than a year ago I felt the need of a mild soporific and purchased an original packet of veronal from a pharmacist in Singapore. At night, after dinner, I took about seven grains of the drug, and passed a very comfortable and restful night. The day after taking this dose I noticed a slightly tender, somewhat itchy, erythematous, macule over the first metacarpophalangeal joint of the left hand. The day following the lesion had become rather swollen and raised above the surrounding skin and was of a brilliant red color and felt tense and a little sore. A day or two later the surface of this maculo-papule, which measured 2×1½ cm., was covered with a
Saddle embolus of the aorta
Authors: I. J. Schatz
Journal: JAMA (1976)

ACUTE embolic occlusion of the terminal aorta at its bifurcation is a common and life-threatening cardiovascular catastrophe. Aortic saddle embolus accounts for approximately 10% of all peripheral arterial emboli. It is invariably a reflection of severe, coexisting heart disease. Physicians must be sufficiently familiar with the characteristic clinical manifestations of saddle embolus in order to reach the diagnosis promptly, recommend appropriate therapy, and avoid irreversible ischemic injury. Time is of the essence in the successful treatment of patients with this disease. <h3>Pathogenesis</h3> Sudden embolic occlusion of the terminal aorta is almost always caused by dislodged intracardiac mural thrombi, from either the left ventricle or left atrium. Perhaps the most common source of large emboli is the left ventricular chamber in patients who have had a recent myocardial infarction. Endocardial inflammation and roughening becomes the site for mural thrombosis. During early convalescence from infarction, such thrombi may become detached from the
Postoperative pain.
Authors: M Rosen, T R Austin
Journal: BMJ (1979)

although haemolysis is to be expected if copper is indeed involved in the aetiology of Indian childhood cirrhosis, its presence has yet to be adequately documented and we are grateful to Professor Ozsoylu for the opportunity of discussing this point.Neither caeruloplasmin nor reduced glutathione was measured in our patient, although the former (as copper oxidase) was elevated in the patients of Kapoor et al.2
Editorial on Screening for Chlamydia and Gonorrhea Corrected
Journal: JAMA (2021)

The Editorial titled “Screening for Chlamydia and Gonorrhea,” published in the September 14, 2021, issue of JAMA,1 has been updated to fix the year of the initial USPSTF recommendation; wording in 3 other paragraphs; and the correct citation for reference 2. This article was corrected online.
Dynamic risk profiling of HCC recurrence after curative intent liver resection
Authors: Tommy Ivanics, Carla Fiorella Murillo Perez, Marco P. A. W. Claasen, Madhukar S. Patel, Gabriela Morgenshtern, Lauren Erdman, Chaya Shwaartz, Luckshi Rajendran, Grainne M. O’Kane, Bettina E. Hansen, Sean P Cleary, Gonzalo Sapisochin
Journal: Hepatology (2022)

Following liver resection (LR) for HCC, the likelihood of survival is dynamic, in that multiple recurrences and/or metastases are possible, each having variable impacts on outcomes. We sought to evaluate the natural progression, pattern, and timing of various disease states after LR for HCC using multistate modeling and to create a practical calculator to provide prognostic information for patients and clinicians.Adult patients undergoing LR for HCC between January 2000 and December 2018 were retrospectively identified at a single center. Multistate analysis modeled post-LR tumor progression by describing transitions between distinct disease states. In this model, the states included surgery, intrahepatic recurrence (first, second, third, fourth, fifth), distant metastasis with or without intrahepatic recurrence, and death. Of the 486 patients included, 169 (34.8%) remained recurrence-free, 205 (42.2%) developed intrahepatic recurrence, 80 (16.5%) developed distant metastasis, and 32 (7%) died. For an average patient having undergone LR, there was a 33.1% chance of remaining disease-free, a 31.0% chance of at least one intrahepatic recurrence, a 16.3% chance of distant metastasis, and a 19.8% chance of death within the first 60 months post-LR. The transition probability from surgery to first intrahepatic recurrence, without a subsequent state transition, increased from 3% (3 months) to 17.4% (30 months) and 17.2% (60 months). Factors that could modify these probabilities included tumor size, satellite lesions, and microvascular invasion. The online multistate model calculator can be found on https://multistatehcc.shinyapps.io/home/.In contrast to standard single time-to-event estimates, multistate modeling provides more realistic prognostication of outcomes after LR for HCC by taking into account many postoperative disease states and transitions between them. Our multistate modeling calculator can provide meaningful data to guide the management of patients undergoing postoperative surveillance and therapy.
ISA101 and nivolumab for HPV-16<sup>+</sup>cancer: updated clinical efficacy and immune correlates of response
Authors: Luana Guimaraes de Sousa, Kimal Rajapakshe, Jaime Rodriguez Canales, Renee L Chin, Lei Feng, Qi Wang, Tomas Z Barrese, Erminia Massarelli, William William, Faye M Johnson, Renata Ferrarotto, Ignacio Wistuba, Cristian Coarfa, Jack Lee, Jing Wang, Cornelis J M Melief, Michael A Curran, Bonnie S Glisson
Journal: Journal for ImmunoTherapy of Cancer (2022)

The combination of ISA101, a human papilloma virus (HPV) 16 peptide vaccine, and nivolumab showed a promising response rate of 33% in patients with incurable HPV-16
Porphyria
Authors: G. Dean
Journal: BMJ (1953)

ADRENAL PSEUDOHERMAPHRODITISMMEDICTISH 1291better index of the adrenocortical function than is the total 17-ketosteroid output.Comparison of the effect of operation and of cortisone on D.H.A output in cases conforming to type A has not pro- ceeded far enough to admit of definite conclusions, but preliminary work indicates that as a result of unilateral adrenalectomy D.H.A. is reduced in much the same propor- tion as the total 17-ketbsteroids.In other words, there is no.deviation from type /B.The effect of treatment with corti- sone compared with that of unilateral adrenalectomy de- pends on the dosage.When only enough cortisone has been administered to halve the total 17-ketosteroid output-that is, corresponding approximately to the reduction that can be achieved by the removal of one adrenal-there is again no deviation from type /.If, however, enough cortisone is given to bring down the total 17-ketosteroids to normal values, the D.H.A. is almost completely eliminated, signifying a change from type ,B to type a. Summary A short clinical and biochemical review of 37 cases of adrenal pseudohermaphroditism is presented.Further biochemical studies show, on the basis of dehydroisoandrosterone excretion, that these patients fall into two distinct groups.The effects of unilateral and bilateral adrenalectomy on 17-ketosteroid excretion are shown.Observations of the action of cortisone on 17-keto- steroid excretion are also discussed.Treatment is more effective when undertaken before puberty.
Evaluation of Online Patient Portal vs Text-Based Blood Pressure Monitoring Among Black Patients With Medicaid and Medicare Insurance Who Have Hypertension and Cardiovascular Disease
Authors: Lauren A. Eberly, Monika Sanghavi, Howard M. Julien, Laura Burger, Neel Chokshi, Jennifer Lewey
Journal: JAMA Network Open (2022)

This pilot randomized clinical trial evaluates the increased uptake and acceptability of a text-based model for home blood pressure monitoring compared with online portal use among Black patients with Medicaid and Medicare insurance who have hypertension and cardiovascular disease.
Royal malady.
Authors: A. Gajdos
Journal: BMJ (1968)

massage failed to produce a palpable femoral pulse, and we assumed that the reason for this was that the grossly over-distended lungs cushioned the pressure applied to the anterior chest wall, and prevented it from being trans- mitted to the heart.In the next two cases external cardiac massage was similarly in- effective, but open massage immediately pro- duced a palpable femoral pulse and was rapidly followed by a restoration of spon- taneous cardiac pulsation in sinus rhythm.Unfortunately, in one case open cardiac massage was not started in time to prevent irreparable cerebral damage.Open cardiac massage may seem a formid- able undertaking, particularly to a physician, but it is in fact a simple procedure, and in almost every hospital the services of a sur- geon can readily be obtained to close the wound.In the light of our recent experience, which is happily not extensive, we now take the view that when a patient with status asthmaticus develops cardiac arrest in hos- pital and this is shown to be due to ventricular asystole the proper course is to under- take open cardiac massage without delay.-Weare, etc., I.
LECTURES ON INTRACRANIAL SURGERY.IX.—THE OPERATIVE TREATMENT OF IDIOCY.
Authors: EMORY LANPHEAR
Journal: JAMA (1895)

It is with a feeling of diffidence that I take up the subject of the surgical treatment of idiocy, for I am uncertain as to the advisability of such measures; yet as medical literature, some two years ago, was glowing with accounts of wonderful results obtained, and periodicals of to-day contain articles condemning the plan as unscientific and valueless, the subject deserves more than passing notice. <h3>HISTORY OF THE OPERATION.</h3> The proposition to relieve idiocy by operation originated in America. Dr. William Fuller, of Grand Rapids, Mich., who was at the time Professor of Anatomy in the Medical College of Montreal, Canada, at a meeting of the Montreal Medical Society, in 1878, read a paper upon the subject, with the report of a case operated upon by himself. Moreover, Louis
Viable germ cell tumor and teratoma can be distinguished from necrosis in postchemotherapy retroperitoneal lymph node dissection specimens by a combination of microRNA-371a-3p and 375-5p.
Authors: Tim Nestler, Lara Kremer, Melanie von Brandenstein, Barbara Koeditz, Pia Paffenholz, Martin Hellmich, David Pfister, Axel Heidenreich
Journal: Journal of Clinical Oncology (2022)

421 Background: Our objective was to identify a combination of microRNAs (miRNA) to differentiate between viable tumor (V) or teratoma (T) and necrosis/fibrosis (N) in pcRPLND specimens of metastatic nonseminomatous germ cell tumor (NSGCT) patients with residual masses ≥1cm after chemotherapy. Our hypothesis is that a biomarker guided therapy could reduce overtreatment with pcRPLND in patients with only N. Methods: Forty-eight patients were identified, n = 16 each with T/V/N. Representative regions of T/V/N were microdissected, subsequently total RNA was isolated and miRNA expression was analyzed for miR-371a-3p, 375-3p, and 375-5p using qPCR. ROC analysis was performed for each miRNA and for all combinations in order to determine the discriminatory capacity of V and T vs. N. Results: For the group comparisons of V vs. N miR-371a-3p achieved the highest fold change (FC) of 31.1 (p = 0.023) while for T vs. N miR-375-5p performed best (FC 64,2; p &lt; 0.001). Likewise, the most accurate AUC for V was 0.75 using miR-371a-3p, for T 0.80 using miR-375-5p. Combining the best performing miRNAs for V and T resulted in an AUC of 0.94 with a sensitivity of 93.75, specificity of 93.75, PPV of 96.8 and NPV of 83.3. Conclusions: In pcRPLND tissue samples V and T could be distinguished from necrosis/fibrosis by combining miR-371a-3p and miR-375-5p with great accuracy. This combination of miRNAs might serve as new biomarker in the future, in order to spare miRNA-negative patients from pcRPLND. However, further studies analyzing patient’s serum are needed to confirm the clinical impact of these biomarkers.
Strychnine for Drunkenness.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal