tbuckley/cabot-search huggingface dataset:
Transduodenal EUS Staging of a Colonic Adenocarcinoma
Authors: T Togliani, S Pilati
Journal: Endoscopy (2021)

The PET-TC scan staging of an adenocarcinoma of the right colonic flessure suspected a duodenal infiltration. Upper GI endoscopy displayed an irregular duodenal ulceration, with unrevealing biopsies. To assess the relationship between the duodenum and the surrounding organs, an EUS was planned. EUS displayed a thickened duodenal wall in continuity with an hypoechoic 6 cm lesion containing air bubbles, that was attributable to the colonic tumor. The laparoscopic exploration confirmed the firm adhesion of the colon to the duodenum; a cecostomy and a gastro-jejunostomy were created. In this interesting case an upper EUS helped us diagnose a T4b intestinal tumor.
Prescription Drug Abuse
Authors: Neil Kirschner, Thomas G. Tape
Journal: Annals of Internal Medicine (2014)

Letters19 August 2014Prescription Drug AbuseNeil Kirschner, PhD and Thomas G. Tape, MDNeil Kirschner, PhDFrom American College of Physicians, Philadelphia, Pennsylvania; and University of Nebraska Medical Center, Omaha, Nebraska.Search for more papers by this author and Thomas G. Tape, MDFrom American College of Physicians, Philadelphia, Pennsylvania; and University of Nebraska Medical Center, Omaha, Nebraska.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L14-5016-6 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Retan asserts that the College supports random urine drug testing for patients at substantial risk for prescription drug abuse and then questions the appropriateness of this position. In actuality, the College does not take this position.Position statement 8 recognizes only that third parties (for example, public and private payers and law enforcement officials) may require such testing in patients identified as being at substantial risk and makes recommendations for when such testing is mandated. These recommendations are that physicians should not do such tests without patient consent and that “neither the patient nor the physician should ... Author, Article, and Disclosure InformationAuthors: Neil Kirschner, PhD; Thomas G. Tape, MDAffiliations: From American College of Physicians, Philadelphia, Pennsylvania; and University of Nebraska Medical Center, Omaha, Nebraska.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L14-0180. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPrescription Drug Abuse: Executive Summary of a Policy Position Paper From the American College of Physicians Neil Kirschner , Jack Ginsburg , and Lois Snyder Sulmasy , for the Health and Public Policy Committee of the American College of Physicians* Prescription Drug Abuse J. Walden Retan Prescription Drug Abuse Robert Newman Prescription Drug Abuse Robert Newman Prescription Drug Abuse J. Walden Retan Metrics 19 August 2014Volume 161, Issue 4Page: 306-307KeywordsDisclosureDrug abuseDrug addictionDrug dependenceDrugsPatient advocacyPrescription drug abuseSubstance abuseTreatment guidelinesUrine ePublished: 19 August 2014 Issue Published: 19 August 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Targeted inhibition of EPAS1-driven IL-31 production by a small-molecule compound
Authors: Yasuhisa Kamikaseda, Takehito Uruno, Kazufumi Kunimura, Akihito Harada, Kuniko Saiki, Kounosuke Oisaki, Daiji Sakata, Takeshi Nakahara, Makiko Kido-Nakahara, Motomu Kanai, Seiji Nakamura, Yasuyuki Ohkawa, Masutaka Furue, Yoshinori Fukui
Journal: Journal of Allergy and Clinical Immunology (2021)

IL-31 is a major pruritogen associated with atopic dermatitis (AD). Although a specific antibody for IL-31 receptor has been shown to alleviate pruritus in patients with AD, therapeutic approaches to inhibition of IL-31 production remain unexploited. IL-31 production by TH cells critically depends on the transcription factor EPAS1, which mediates IL31 promoter activation in collaboration with SP1.We aimed at developing small-molecule inhibitors that selectively block IL-31 production by TH cells.We generated the reporter cell line that inducibly expressed EPAS1 in the presence of doxycycline to mediate Il31 promoter activation, and we screened 9600 chemical compounds. The selected compounds were further examined by using TH cells from a spontaneous mouse model of AD and TH cells from patients with AD.We have identified 4-(2-(4-isopropylbenzylidene)hydrazineyl)benzoic acid (IPHBA) as an inhibitor of IL31 induction. Although IPHBA did not affect nonspecific T-cell proliferation, IPHBA inhibited antigen-induced IL-31 production by TH cells from both an AD mouse model and patients with AD without affecting other cytokine production and hypoxic responses. In line with this, itch responses induced by adoptive transfer of IL-31-producing TH cells were attenuated when mice were orally treated with IPHBA. Mechanistically, IPHBA inhibited the association between EPAS1 and SP1, resulting in defective recruitment of both transcription factors to the specific sites of the IL31 promoter. We also determined the structure-activity relationship of IPHBA by synthesizing and analyzing 201 analogous compounds.IPHBA could be a potential drug leading to inhibition of EPAS1-driven IL-31 production.
Exercise training in patients with severe left ventricular dysfunction. Hemodynamic and metabolic effects.
Authors: M JSullivan, M BHigginbotham, F RCobb
Journal: Circulation (1988)

We studied the effects of exercise training in patients with chronic heart failure attributed to left ventricular dysfunction (ejection fraction, 24 +/- 10%). Twelve ambulatory patients with stable symptoms underwent 4-6 months of conditioning by exercising 4.1 +/- 0.6 hr/wk at a heart rate corresponding to 75% of peak oxygen consumption. Before and after training, patients underwent maximal bicycle exercise testing with direct measurement of central hemodynamic, leg blood flow, and metabolic responses. Exercise training resulted in a decrease in heart rate at rest and submaximal exercise and a 23% increase in peak oxygen consumption from 16.8 +/- 3.8 to 20.6 +/- 4.7 ml/kg/min (p less than 0.01). Heart rate, arterial lactate, and respiratory exchange ratio were unchanged at peak exercise after training. Maximal cardiac output tended to increase from 8.9 +/- 2.7 to 9.9 +/- 3.2 1/min and contributed to improved peak oxygen consumption in some patients, although this change did not reach statistical signific...
Experimental model of effects on normal tissue of injury current from ischemic region.
Authors: R CTan, TOsaka, R WJoyner
Journal: Circulation Research (1991)

An ischemic myocardial region contains cells with a depolarized resting membrane potential. This depolarization leads to an intercellular current flow between the ischemic region and the surrounding normal myocardial cells, which has been termed an  current. We have devised an experimental model system in which an isolated rabbit ventricular cell is electrically coupled to a model depolarized cell to evaluate the effects of this injury current on the electrical properties of a normal ventricular cell. We found that the action potential duration of the isolated cell could be reversibly altered by varying the coupling resistance such that the action potential duration was shortened by high values of coupling resistance but could be considerably prolonged by lower resistance coupling. We did not observe automaticity in the isolated cell as a consequence of coupling to the depolarized model. The changes in action potential duration were accompanied by alterations in the frequency at which the isolated...
EUS Directed Transgastric Ercp (EDGE) With Direct Cholangioscopy For Endoscopic Manage Of Common Bile Duct Stricture In A Patient With Gastric By-Pass Complications
Authors: M Puig, I Iborra, I Marín, N Caballero, H Uchima, C Gené Skrabec, C Matallana, A Caballero, J Colan-Hernandez, P Moreno Santabárbara, V Moreno de Vega
Journal: Endoscopy (2021)

Background and clinical case Biliary therapy is challenging in bariatrc surgery. EUS allows biliary access.
Effects of temperature and sodium on myocardial and hepatocellular fatty acid uptake.
Authors: KVyska, WStremmel, WMeyer, GNotohamiprodjo, KMinami, HMeyer, RKörfer
Journal: Circulation Research (1994)

Fatty acid influx into human myocardium was studied in 15 patients during the cooling phase of cardiopulmonary bypass at myocardial temperatures of 37 degrees to 25 degrees C. The fitting of the data to a functional relation, developed in this study, revealed fatty acid influx to be a temperature-dependent saturable process corresponding to a Michaelis-Menten constant (Km) at 37 degrees C of 0.26 +/- 0.084 mumol/g, a maximal fatty acid influx velocity (Vmax) at 37 degrees C of 0.28 +/- 0.045 mumol/g per minute, activation energy for fatty acid binding to the putative carrier (E) of 23.8 +/- 5.6 kcal/mol, and a free energy for conformational change of the carrier (U) of 10.9 +/- 8.0 kcal/mol. In short-term cultured hepatocytes, Km increased in the absence of Na+ from 171 +/- 48 to 301 +/- 71 nmol/L, and Vmax of [3H]oleate decreased from 1063 +/- 69 to 847 +/- 68 pmol/min per milligram protein. The fitting of these data to a functional relation revealed a transmembrane potential-dependent component of param...
Direct effect of beta-adrenergic stimulation on renin release by the rat kidney slice in vitro.
Authors: M HWeinberger, WAoi, D PHenry
Journal: Circulation Research (1975)

Controversy exists regarding the mechanism by which catecholamines stimulate renin secretion in vivo. A sensitive rat kidney slice system was utilized to study the direct effects of adrenergic agonists and antagonists on renin release in vitro. Catecholamines were protected from degradation by the addition of ascorbic acid to the incubation medium. Significant dose-related stimulation of renin release was observed with epinephrine and norepinephrine in concentrations from 1.5 times 10(-9) to 1.5 times 10(-7)M and with isoproterenol in concentrations from 2 times 10(-9) to 2 times 10(-7)M. No significant stimulation was seen with 10(-10)M concentrations of the three agents. Methoxamine (10(-6)M) stimulated renin release significantly (P less than 0.01). The stimulation observed with epinephrine, norepinephrine, or isoproterenol was blocked by d,l- and l-propranolol (2 times 10(-4)M) but not by d-ropranolol (2 times 10(-4)M) or phentolamine (9 times 10(-4)M). Methoxamine-induced stimulation was abolished by...
Influence of chronic captopril therapy on the infarcted left ventricle of the rat.
Authors: J MPfeffer, M APfeffer, EBraunwald
Journal: Circulation Research (1985)

To determine whether the relationship between infarct size and ventricular performance, volume, and compliance could be altered favorably, captopril was administered to rats for 3 months following coronary artery ligation. Baseline left and right ventricular and systemic arterial pressures and aortic blood flow, and maximal stroke volume and cardiac indices attained during a volume loading, were measured. Passive pressure-volume relations of the left ventricle were determined, and the slopes of segments of this relation were analyzed to characterize ventricular chamber stiffness. In untreated rats, left ventricular end-diastolic pressure progressively rose (from 5-28 mm Hg) as a function of infarct size, whereas, in captopril-treated rats, filling pressure remained within normal limits (5 +/- 1 mm Hg) in all but those with extensive infarcts. Chronic captopril therapy reduced baseline mean arterial pressure and total peripheral resistance, yet maintained cardiac and stroke outputs in rats both with and wi...
A multivariate approach for interpreting treadmill exercise tests in coronary artery disease.
Authors: J LBerman, JWynne, P FCohn
Journal: Circulation (1978)

To determine the value of a multivariate approach for the analysis of the treadmill exercise tolerance test (ETT), 237 patients referred for evaluation of chest pain who underwent a standard Bruce protocol ETT and coronary arteriography were studied. Predictive value of a positive ETT was 0.78 (43/55) using 1.0--1.9 mm ST segment depression criterion, 0.97 (59/61) using greater than or equal to 2.0 mm ST segment depression. When the 1.0--1.9 mm ST criterion was combined with peak systolic blood pressure-heart rate product (double product) less than or smaller than 23,000, exercise duration less than 6 minutes, and ST depression for greater than 3 minutes into recovery, predictive value improved to 0.89 in 18 patients with any two of the above. Predictive value for multivessel disease was also improved using non-ST criteria. Predictive value of a negative ETT for absence of coronary artery disease was 0.60 (29/48), and was 0.86 (12/14) if double product was greater than or equal to 30,000. Presence of ches...
Complicated Gastric Duplication Cyst in Adult: a Case Report
Authors: N Keeratibharat, J Chansangrat
Journal: Endoscopy (2021)

Aims Gastric duplication cyst is a very rare gastrointestinal congenital congenital anomaly and most of the cases are diagnosed in the neonatal period. It is rarely observed in adults. Gastric duplication cysts are usually asymptomatic and usually discovered incidentally during endoscopy or laparotomy or very rarely after getting complicated. Accurate diagnosis of these cysts before resection is difficult. Differential diagnoses are varied, including gastrointestinal stromal tumors (GISTs), neuroendocrine tumors, pancreatic pseudocysts, and neurogenic tumors.Malignant transformation of a gastric duplication cyst is very rare.We present a case of complicated noncommunicating gastric duplication cysts in adults who presented with clinical of gastric outlet obstruction and successful endoscopic treatment.
A new protocol for removal of the endothelium from the perfused rat hind-limb preparation.
Authors: VRalevic, FKristek, OHudlická, GBurnstock
Journal: Circulation Research (1989)

A new protocol has been developed for selective removal of the endothelium from the arteries of the perfused rat hind-limb preparation. The hind limb was perfused with oxygenated Krebs-Ringer bicarbonate solution with a combination of high flow and timed air bubbles (2 minutes at high flow followed by 5 minutes of air bubbles, followed by a further 2 minutes at high flow). Representative vessels at different diameters of the arterial tree--the femoral artery, the artery supplying the extensor hallucis proprius muscle, and the arteries, arterioles, and capillaries within the hallucis proprius muscle--were taken for examination by transmission and scanning electron microscopy. A graded degree of damage occurred along the length of the hind-limb vasculature, with endothelial cells having been completely removed from the femoral artery, removed from or severely damaged in the artery supplying the hallucis proprius muscle, and partially damaged in arteries within the hallucis proprius muscle. However, no damag...
Endocuff Vision Improves ADR in Low Detectors: Results of the “Itavision” Randomized Controlled Trial
Authors: G Antonelli, M Zorzi, C Senore, C Hassan
Journal: Endoscopy (2021)

Aims Endocuff Vision (EV, Arc Medical Design Ltd., Leeds, England) has shown to increase mucosal exposure, and consequently adenoma detection rate (ADR), during colonoscopy, but its role in positive Faecal Immunochemical Test (FIT+) subjects within an organised colorectal cancer population-based screening program is uncertain. This nationwide multicentre study aims to assess possible benefits and harms of implementing EV in a FIT-based screening program.
Decongestion discriminates risk for one‐year mortality in patients with improving renal function in acute heart failure
Authors: Nicholas Wettersten, Yu Horiuchi, Dirk J. van Veldhuisen, Joachim H. Ix, Christian Mueller, Gerasimos Filippatos, Richard Nowak, Christopher Hogan, Michael C. Kontos, Chad M. Cannon, Gerhard A. Müeller, Robert Birkhahn, Pam Taub, Gary M. Vilke, Stephen Duff, Kenneth McDonald, Niall Mahon, Julio Nuñez, Carlo Briguori, Claudio Passino, Alan Maisel, Patrick T. Murray
Journal: European Journal of Heart Failure (2021)
Spatial transcriptomics for respiratory research and medicine
Authors: Sandra Curras-Alonso, Juliette Soulier, Thomas Walter, Florian Mueller, Arturo Londoño-Vallejo, Charles Fouillade
Journal: European Respiratory Journal (2021)

<b>In combination with scRNA-seq, spatial transcriptomics have the potential to lead to an unprecedented view of lung architecture at the single cell level, providing original information on lung physiology and physiopathology</b>https://bit.ly/3uDYir0
Computerized axial tomography of the chest for visualization of "absent" pulmonary arteries.
Authors: H MSondheimer, MOliphant, BSchneider, R EKavey, M SBlackman, F BParker
Journal: Circulation (1982)

To expand the search for central pulmonary arteries in six patients with absence of cardiac-pulmonary continuity, computerized axial tomography (CAT) of the chest was performed. The CAT scans were compared with previous arteriograms and pulmonary vein wedge angiograms. Three patients with type IV truncus arteriosus were studied, and none had a central, right or left pulmonary artery on CAT scan. However, two patients with tetralogy of Fallot with pulmonary atresia and a patent ductus arteriosus to the right lung demonstrated the presence of a left pulmonary artery. In addition, one child with truncus arteriosus with absent left pulmonary artery demonstrated a left pulmonary artery on the CAT scan. The CAT scan may therefore enhance our ability to search for disconnected pulmonary arteries in children with complex cyanotic congenital heart disease.
Virtual Chromoendoscopy for Real-Time Assessment of Colorectal Polyps’ Histology: Is There any Predictor of Diagnostic Performance?
Authors: I Ferchichi, M Sabbah, N Bellil, D Trad, N Bibani, A Ouakaa, H Elloumi, D Gargouri
Journal: Endoscopy (2021)

Aims Virtual chromoendoscopy (VC) such as Narrow band imaging (NBI) or Flexible spectral imaging color enhancement (FICE) offer better resolution of the pit pattern and the vascular pattern of colorectal polyps, which allows real-time assessment of these lesions’ histology. The aim of this study was to assess virtual chromoendosctopy’s performance in predicting colorectal polyps’ histology and to determine predictors of diagnostic accuracy.
Diseases of the Thyroid Gland and Their Surgical Treatment.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system.
Authors: K TWeber, C GBrilla
Journal: Circulation (1991)

Left ventricular hypertrophy (LVH) is the major risk factor associated with myocardial failure. An explanation for why a presumptive adaptation such as LVH would prove pathological has been elusive. Insights into the impairment in contractility of the hypertrophied myocardium have been sought in the biochemistry of cardiac myocyte contraction. Equally compelling is a consideration of abnormalities in myocardial structure that impair organ contractile function while preserving myocyte contractility. For example, in the LVH that accompanies hypertension, the extracellular space is frequently the site of an abnormal accumulation of fibrillar collagen. This reactive and progressive interstitial and perivascular fibrosis accounts for abnormal myocardial stiffness and ultimately ventricular dysfunction and is likely a result of cardiac fibroblast growth and enhanced collagen synthesis. The disproportionate involvement of this nonmyocyte cell, however, is not a uniform accompaniment to myocyte hypertrophy and LV...
Effects of adenosine on human coronary arterial circulation.
Authors: R FWilson, KWyche, B VChristensen, SZimmer, D DLaxson
Journal: Circulation (1990)

Adenosine is a potent vasodilator used extensively to study the coronary circulation of animals. Its use in humans, however, has been hampered by lack of knowledge about its effects on the human coronary circulation and by concern about its safety. We investigated in humans the effects of adenosine, administered by intracoronary bolus (2-16 micrograms), intracoronary infusion (10-240 micrograms/min), or intravenous infusion (35-140 micrograms/kg/min) on coronary and systemic hemodynamics and the electrocardiogram. Coronary blood flow velocity (CBFV) was measured with a 3F coronary Doppler catheter. The maximal CBFV was determined with intracoronary papaverine (4.5 +/- 0.2.resting CBFV). In normal left coronary arteries (n = 20), 16-micrograms boluses of adenosine caused coronary hyperemia similar to that caused by papaverine (4.6 +/- 0.7.resting CBFV). In the right coronary artery (n = 5), 12-micrograms boluses caused maximal hyperemia (4.4 +/- 1.0.resting CBFV). Intracoronary boluses caused a small, brie...
Localization of gene for familial hypertrophic cardiomyopathy to chromosome 14q1 in a diverse US population.
Authors: J FHejtmancik, P ABrink, JTowbin, RHill, LBrink, TTapscott, ATrakhtenbroit, RRoberts
Journal: Circulation (1991)

BACKGROUNDFamilial hypertrophic cardiomyopathy, an inherited primary cardiac abnormality characterized by ventricular hypertrophy, is the leading cause of sudden death in the young. Recent application of restriction fragment length polymorphism markers has provided provocative results, with localization to chromosome 18 (Japanese studies), 16 (Italian studies), 14 (US and French-Canadian studies), and two (National Institutes of Health studies) indicating genetic heterogeneity. Interpretation remains speculative until at least one of these loci is confirmed in unrelated pedigrees by independent investigators.METHODS AND RESULTSWe studied eight unrelated families of varied ethnic origins across the United States. DNA from each individual was digested with restriction enzymes TaqI or BamHI and analyzed by Southern blots followed by hybridization with probes T cell receptor alpha (TCRA), myosin heavy chain beta, D14S25, and D14S26. Multipoint linkage analysis showed a maximum lod score of 4.3, placing the lo...