tbuckley/cabot-search huggingface dataset:
cAMP-response element binding protein mediates podocyte injury in diabetic nephropathy by targeting lncRNA DLX6-AS1
Authors: Wen Zheng, Jia Guo, Xiaoqing Lu, Yingjin Qiao, Dongwei Liu, Shaokang Pan, Lulu Liang, Chang Liu, Hongchao Zhu, Zhihong Liu, Zhangsuo Liu
Journal: Metabolism (2022)

Progressive proteinuria is one of the earliest clinical features of diabetic nephropathy (DN). In our previous study, lncRNA DLX6-AS1 (DLX6-AS1, Dlx6os1 in the mouse) was found to be associated with the extent of albuminuria in DN patients. Furthermore, the lack of Dlx6os1 was pivotal in switching off the inflammatory response in db/db mouse model. However, the regulatory factors responsible for elevated DLX6-AS1 in DN remains unknown.To identify potential regulatory factors for DLX6-AS1, JASPAR database and DNA pull down combined subsequent liquid chromatography-tandem mass spectrometry were used. Dual-luciferase reporter assay and chromatin immunoprecipitation were then performed to confirm binding sites. We also investigated the effects of the regulatory factors on DN progression in db/db mouse model and cultured human podocytes.Our analyses demonstrated that cAMP-response element binding protein (CREB) was highly expressed and closely associated with DLX6-AS1 in DN. In db/db mouse and in cultured podocytes, CREB silencing significantly reduced the level of DLX6-AS1 or Dlx6os1 and attenuated renal damage. Mechanistically, CREB overexpression aggravated renal inflammation and destroyed the structure of podocytes by targeting DLX6-AS1. The damaging role of CREB in podocyte injury was also inhibited by 666-15, a selective inhibitor, in a dose-dependent manner. In vivo, the inhibition of CREB by 666-15 significantly attenuated albuminuria and ameliorated inflammatory infiltration in podocytes.Our findings indicated that CREB is a key mediator of podocyte injury and acts by regulating DLX6-AS1. Thus, CREB may be an effective and potential therapeutic target for the treatment of DN.
Current Comment
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
P124: EFFICACY OF NON-PHARMACOLOGICAL INTERVENTIONS TO REDUCE PAIN IN CHILDREN WITH SICKLE CELL DISEASE: A SYSTEMATIC REVIEW
Authors: C Vuong, S van Veelen, J Gerritsma, C de Groot-Eckhardt, S Verbeek, M Peters, K Fijnvandraat
Journal: HemaSphere (2022)

Background: Pain is the clinical hallmark of sickle cell disease (SCD) and leads to frequent emergency department visits, psychological sequelae and a decreased health-related quality of life. Although pharmacological treatments to target and prevent pain are evolving, children still experience frequent pain. Although pharmacological treatments are effective, they are accompanied by side effects. Therefore, complementary non-pharmacological pain strategies are needed. The literature on this topic is heterogeneous and we urgently require an evaluation of the evidence supporting efficacy of non-pharmacological interventions in reducing the frequency and intensity of sickle cell related pain in children with SCD. Aims: The aim of this systematic review is to evaluate the evidence on the efficacy of non-pharmacological interventions in reducing the frequency and intensity of sickle cell related pain in children with SCD. Methods: We performed a literature search through October 2021 using the terms ‘sickle cell’, ‘pain’, ‘psychotherapy’, ‘analgesic’, and ‘health service’. We included randomized controlled trials and quasi-experimental studies that investigated the efficacy of non-pharmacological interventions on (1) pain frequency and intensity, and (2) analgesic and health service use in children with SCD. Results: Eleven articles including 441 participants were included. Nine studies performed in the outpatient clinic investigated the efficacy of cognitive behavioral therapy, biofeedback, and massage. Two studies performed during hospital admission included virtual reality and yoga. Five studies reported significant reductions in the frequency and/or intensity of pain. One study reported a significantly reduced analgesic use. The remaining six studies did not report a reduction in pain related outcomes. Conclusion: The evidence for non-pharmacological interventions to reduce pain in children with SCD seems promising, but due to heterogeneity of the included/published studies no firm conclusions can be drawn. To target SCD related pain in children, a multidisciplinary approach focusing on the physical, psychological and social aspects seems most appropriate, but the clinical implementation of non-pharmacological interventions first needs further exploration. References 1. Brandow et al, Blood advances 2020; 4:12. 2. Williams et al, Journal of Pain and Symptom Management 2016; 51:2. 3. Anie et al, The Cochrane database of systematic reviews 2015; 5:5.
So You Can Teach Old Fibroblasts New Tricks
Authors: Amaya Virós, Maria Romina Girotti, Richard Marais
Journal: Cancer Discovery (2016)

Abstract Summary: New data show that as dermal fibroblasts grow old, they increase their secretion of the WNT antagonist sFRP2 to drive melanoma cell metastasis. sFRP2 suppresses β-catenin and MITF signaling in melanoma cells, downregulating the redox regulator APE1, making melanoma cells more sensitive to oxidative stress and driving resistance to BRAF inhibitors. Thus, the aging microenvironment in elderly patient skin activates a signaling pathway that drives more aggressive melanoma cell behavior. Cancer Discov; 6(6); 581–3. ©2016 AACR.
MISCELLANY.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Oral Eosinophil-lowering Drug Dexpramipexole Improves FEV1 Largely Thorough its Effect on FVC
Authors: Calman Prussin, Michael Bozik, James Mather, Donald Archibald, Steven Dworetzky, Randall Killingsworth, Sergei Ochkur, Elizabeth Jacobsen, Salman Siddiqui, William Busse
Journal: Journal of Allergy and Clinical Immunology (2022)
Demographic factors and disparate outcomes in mycosis fungoides: retrospective analysis of a racially diverse 440‐patient cohort from Detroit, Michigan, <scp>USA</scp>
Authors: Connor R. Buechler, Ethan Sagher, Aaron Tisack, Gordon Jacobsen, Henry W. Lim, Chauncey McHargue, Ben J. Friedman, Qing‐Sheng Mi, David M. Ozog, Jesse Veenstra
Journal: British Journal of Dermatology (2022)

Journal Article Demographic factors and disparate outcomes in mycosis fungoides: retrospective analysis of a racially diverse 440‐patient cohort from Detroit, Michigan, USA Get access Connor R. Buechler, Connor R. Buechler Wayne State University School of Medicine Detroit MI USA https://orcid.org/0000-0002-6454-6200 Search for other works by this author on: Oxford Academic Google Scholar Ethan Sagher, Ethan Sagher Department of Dermatology Henry Ford Health System Detroit MI USA Search for other works by this author on: Oxford Academic Google Scholar Aaron Tisack, Aaron Tisack Wayne State University School of Medicine Detroit MI USA Search for other works by this author on: Oxford Academic Google Scholar Gordon Jacobsen, Gordon Jacobsen Department of Public Health Sciences Henry Ford Health System Detroit MI USA Search for other works by this author on: Oxford Academic Google Scholar Henry W. Lim, Henry W. Lim Department of Dermatology Henry Ford Health System Detroit MI USA Search for other works by this author on: Oxford Academic Google Scholar Chauncey McHargue, Chauncey McHargue Department of Dermatology Henry Ford Health System Detroit MI USA Search for other works by this author on: Oxford Academic Google Scholar Ben J. Friedman, Ben J. Friedman Department of Dermatology Henry Ford Health System Detroit MI USA https://orcid.org/0000-0002-2266-8197 Search for other works by this author on: Oxford Academic Google Scholar Qing‐Sheng Mi, Qing‐Sheng Mi Department of Dermatology Henry Ford Health System Detroit MI USA Search for other works by this author on: Oxford Academic Google Scholar David M. Ozog, David M. Ozog Department of Dermatology Henry Ford Health System Detroit MI USA Search for other works by this author on: Oxford Academic Google Scholar Jesse Veenstra Jesse Veenstra Department of Dermatology Henry Ford Health System Detroit MI USA Correspondence: Jesse Veenstra. Email: jveenst1@hfhs.org https://orcid.org/0000-0002-3576-855X Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 187, Issue 2, 1 August 2022, Pages 246–248, https://doi.org/10.1111/bjd.21034 Published: 01 August 2022
Dose-related allergic adverse events during multi-food oral immunotherapy
Authors: Pooja Gajare, Shu Cao, Brent Anderson, Maria Garcia Lloret, Stacey Skura Zedeck, Laurie Kost, Kari Nadeau, Sharon Chinthrajah, Sayantani Sindher, Andrew Long
Journal: Journal of Allergy and Clinical Immunology (2022)
Editorial: Scleroderma or sclerodermas?
Journal: BMJ (1973)

longed treatment.Lupus erythematosus may develop in about 20% of them and does not always pass into remission when treatment is discontinued.Many other drugs have been used in attempts to suppress recurrent paroxysms; verapamil is a recent example."3Sometimes they are successful, but like coronary artery surgery, treatment tends to be most effective where it is least required and least effective where it is most required.Though physical exertion may sometimes trigger an attack, children with paroxysmal supraventricular tachycardia should be encouraged to live normal lives.No restrictions -should be placed on their activities either at home or school.Above all, they must be taught to regard the attacks as a minor inconvenience and not as evidence of heart disease.
Improving lung transplant outcomes in France: the high emergency lung transplantation programme
Authors: Omar F. Bayomy, Kathleen J. Ramos, Christopher H. Goss
Journal: European Respiratory Journal (2022)

<b>Prioritisation programmes for lung transplant like the high emergency lung transplantation programme in France have the potential to increase transplants in high-risk groups without worsening post-transplant outcomes</b>https://bit.ly/3w1p8es
SANITARY IMPROVEMENT IN SLEEPING CARS.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Whose Autonomy?
Authors: Scott D. Stonington
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Current Medical Literature.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DIGITAL EXTUBATION
Authors: J. R. Clemens
Journal: JAMA (1924)

<h3>To the Editor:</h3> — The method of extubation (digital) described by Dr. John Leshure inThe Journal, February 23, has long been practiced in France, and two well known methods are used—Marfan's and Renault's. The technic was described, with illustrations, by me in the<i>Archives of Pediatrics</i>in February, 1908. [Note.—The letter of Dr. Clemens was referred to Dr. Leshure, whose reply follows.]
Genetic and Molecular Aspects of Hypertension
Authors: Sandosh Padmanabhan, Mark Caulfield, Anna F. Dominiczak
Journal: Circulation Research (2015)

Until recently, significant advances in our understanding of the mechanisms of blood pressure regulation arose from studies of monogenic forms of hypertension and hypotension, which identified rare variants that primarily alter renal salt handling. Genome-wide association and exome sequencing studies over the past 6 years have resulted in an unparalleled burst of discovery in the genetics of blood pressure regulation and hypertension. More importantly, genome-wide association studies, while expanding the list of common genetic variants associated with blood pressure and hypertension, are also uncovering novel pathways of blood pressure regulation that augur a new era of novel drug development, repurposing, and stratification in the management of hypertension. In this review, we describe the current state of the art of the genetic and molecular basis of blood pressure and hypertension.
Creation of a Royal Academy of Medicine in Belgium
Journal: BMJ (1841)

hias instituted a Royal Acfidemy of Medicine in Belgium.'rhe objects for wlich the academy has been instituted are stated to he, I st.T]o assist the government in all questions relative to public health, legal medicine, an(l vete- rinary medicine.2d.Tro promote such researclhes anrd investigagations as are calculated to advance the different branches of the healing art.T'lhe academy is (livide(d into six sections, viz.
'Antineoplastons'
Authors: Saul Green
Journal: JAMA (1992)

UNORTHODOX and unproven treatments for cancer are big business in the United States.<sup>1,2</sup>Usually, individuals providing these treatments offer the public little or no information on their qualifications to treat cancer. Their science is generally presented in unverifiable testimonials, anecdotal material, and non-peer-reviewed magazines sold in supermarkets or publicized on television talk shows and in throwaway health-fair circulars. When reviewed, they reveal a patchwork of half-truths and scientific misinformation. In contrast, there is no lack of published material for the patient who may be considering antineoplaston therapy. There are hundreds of papers about this therapy and its discoverer, Stanislaw R. Burzynski, MD.<sup>3-9</sup>They include his curriculum vitae, his list of publications, explanations of his theory of cancer and the way his treatment works, clinical information, press releases, brochures, abstracts of his speeches, reports of his research results, review articles, government reports, court opinions, legal depositions, records of public
Multidisciplinary virtual management of pulmonary nodules
Authors: D. Polanco, J. González, E. Gracia-Lavedan, L. Pinilla, R. Plana, M. Molina, M. Pardina, F. Barbé
Journal: Pulmonology (2022)

Multidisciplinary nodule clinics provide high-quality care and favor adherence to guidelines. Virtual care has shown savings benefits along with patient satisfaction. Our aim is to describe the first year of operation of a multidisciplinary virtual lung nodule clinic, the population evaluated and issued decisions. Secondarily, among discharged patients, we aimed to analyze their follow-up prior to the existence of our consultation, evaluating its adherence to guidelines. Observational study including all patients evaluated at the Virtual Lung Nodule Clinic (VLNC) (March 2018- March 2019). Clinical and radiological data were recorded. Recommendations, based on 2017 Fleischner Society guidelines, were categorized into follow-up, discharge or referral to lung cancer consultation. Discharged patients were classified according to adherence to guidelines of their previous management, into adequate, prolonged and non-indicated follow-up. A total of 365 patients (58.9% men; median age 64.0 years) were included. Sixty-four percent had smoking history and 23% had chronic obstructive pulmonary disease (COPD). Most nodules were solid (87.4%) and multiple (57.5%). The median diameter was 6.00 mm. 43.8% of patients were discharged following first VLNC evaluation. Among them, 27.5% had received appropriate follow-up, but 66.9% had received poor management. Patients with prolonged follow-up (33.1%) were older (67.0 vs 60.5 years) and had larger nodules (6.00 mm vs 5.00). Non-indicated follow-up patients (33.8%) were more non-smokers (77.8% vs 31.8%) and presented smaller nodules (4.00 vs 5.00 mm). During its first year of operation, the VLNC has evaluated a population with a relevant risk profile for lung cancer development, management of which should be cautious and adhere to guidelines. After the first VLNC assessment, approximately one-half of this population was discharged. It was noticeable that previous follow-up of discharged patients was found poorly adherent to guidelines, with a marked tendency to overmanagement.
Medicine at a Glance
Authors: Phil Gunby
Journal: JAMA (1984)

<b>The second phase</b>is under way (until 1988) in what originally was described (<i>JAMA</i>[MEDICAL NEWS] 1980;244:225) as the nation's first in-depth project to compare diabetes, heart disease, and high blood pressure incidence in two ethnic groups—Mexican Americans and Anglo Americans—in San Antonio, Tex. This phase of the study is evaluating frequency and severity of diabetic complications, attempting to learn whether upper body fat deposits are related to diabetes, and investigating possible genetic factors. In the earlier phase, the 33 investigators (headed by Michael P. Stern, MD, University of Texas Health Science Center, San Antonio) found that diabetes is three to five times more prevalent in Mexican Americans. Stern hypothesizes that genetics plays a role. However, he adds, as Mexican Americans move to a more Anglo culture, incidence of diabetes declines, but cholesterol levels begin to climb, indicating the involvement of dietary factors as well. The study is supported by
<i>ERJ</i>Podcast March 2018: World TB Day
Journal: European Respiratory Journal (2018)

As part of the March issue, the European Respiratory Journal presents the latest in its series of podcasts. To mark World TB Day, chief editor Martin Kolb interviews section editor Giovanni Battista Migliori about the following articles. Borisov SE, Dheda K, Enwerem M, et al. Effectiveness and safety of bedaquiline-containing regimens in the treatment of MDR- and XDR-TB: a multicentre study. Eur Respir J 2017; 49: 1700387. Cabibbe AM, Sotgiu G, Izco S, et al. Genotypic and phenotypic M. tuberculosis resistance: guiding clinicians to prescribe the correct regimens. Eur Respir J 2017; 50: 1702292. Falzon D, Schünemann HJ, Harausz E, et al. World Health Organization treatment guidelines for drug-resistant tuberculosis, 2016 update. Eur Respir J 2017; 49: 1602308. Guglielmetti L, Jaspard M, Le Dû D, et al. Long-term outcome and safety of prolonged bedaquiline treatment for multidrug-resistant tuberculosis. Eur Respir J 2017; 49: 1601799. Miotto P, Tessema B, Tagliani E, et al. A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis . Eur Respir J 2017; 50: 1701354. Pontali E, Sotgiu G, Tiberi S, et al. Cardiac safety of bedaquiline: a systematic and critical analysis of the evidence. Eur Respir J 2017; 50: 1701462. Van der Werf MJ, Hollo V, Ködmön C, et al. Eligibility for shorter treatment of multidrug-resistant tuberculosis in the European Union. Eur Respir J 2017; 49: 1601992.