tbuckley/cabot-search huggingface dataset:
SOCIETY NEWS.
Authors: L. B. Tuckerman
Journal: JAMA (1898)

<h3>Illinois State Medical Society.</h3> —For the forty-eighth annual meeting at Galesburg, May 17, 18 and 19, 1898, a rate of one fare and one third on the certificate plan ($6.50 for the round trip from Chicago) is announced. <h3>Association of Military Surgeons of the United States.</h3> —On account of the occupation of the members in connection with the war with Spain, it is announced that the eighth annual meeting, which was to have taken place June 1, 2 and 3 next, is postponed to a date to be fixed hereafter by the Executive Committee.James E. Pilcher, Capt. Med. Dept. U. S. Army, Secretary;J. D. Griffth, Lieut.-Col. and Med. Dir., N. G. Mo., President, Kansas City, Mo. <h3>Association of American Medical Colleges.</h3> —The annual meeting of this association will be held at the Brown Palace Hotel, Denver, Colo., Monday, June 6, 1898, beginning at 10 o'clock in the morning.
Abstract 369: Engineering Rrm2 to Elevate 2-deoxy-ATP and Improve Cardiomyocyte Function
Authors: Jason D Murray, Xuan Guan, Farid Moussavi-Harami, Sigurast S Olafsson, Charles E Murry, Michael Regnier
Journal: Circulation Research (2017)

Overexpression of ribonucleotide reductase (RNR) in cardiomyocytes increases the amount of cytosolic 2-deoxy-ATP (dATP), which can be used by myosin and significantly increases contraction of cardiac muscle at all levels of calcium activation. Our group is working to develop enhanced dATP as a therapeutic option for heart failure. We have demonstrated that virally-mediated overexpression of RNR elevates dATP and increases the rate and magnitude of contraction and increases left ventricular contraction in normal hearts as well as rodent models of myocardial infarction and dilated cardiomyopathy. RNR is a heterotetramer containing two subunits, Rrm1 and Rrm2. While cardiomyocyte-specific overexpression of Rrm1 is stable, we have observed high variability in expression levels of the Rrm2 subunit in multiple disease models. We hypothesized that this variability was largely due to protein degradation via the ubiquitin-proteasome complex (UPC). We found that pharmacological inhibition of proteasome activity leads to increased expression of Rrm2 in virally-transduced cardiomyocytes in vitro. To confirm the hypothesis that the overexpressed Rrm2 is degraded via UPC-mediated degradation, we engineered mutations in specific ubiquitin-binding degrons of the Rrm2 gene. Transfecting human induced pluripotent stem cell-derived cardiomyocytes resulted in higher levels of Rrm2 than those overexpressing wild-type protein and resulted in higher levels of cytosolic dATP as measured by Liquid chromatography-mass spectrometry. Ongoing and planned experiments will compare the effects of this engineered mutation on Rrm2 overexpression, dATP production, and contractility in cultured cardiomyocytes. Our goal is to develop an improved RNR vector that will be resistant to degradation through the ubiquitin-proteasome pathway and therefore enable more stable and consistent RNR enzyme activity and deoxynucleotide levels of cardiomyocytes transduced in vivo.
Analysis of Routine Computed Tomographic Scans With Radiomics and Machine Learning
Authors: Michael D. Farwell, David A. Mankoff
Journal: JAMA Oncology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Patient-reported outcomes: The anal cancer patient lived experience.
Authors: Martha Raymond, Margaret-Ann Simonetta
Journal: Journal of Clinical Oncology (2022)

2 Background: Anal Cancer incidence and deaths from the disease have been rising in the United States for the past two decades. Data published in the Journal of the National Cancer Institute (11/19/2019) indicate from 2001 to 2015, anal cancer overall incidence increased by 2.7% per year and deaths rose by 3.1 % each year. This data indicates that anal cancer may be one of the fastest growing causes of cancer incidence and mortality. Now, especially with data indicating the rise in incidence rate, it is imperative that the anal cancer patient lived experience be better understood, including gaps in awareness and prevention education that may lead to earlier diagnosis. The Raymond Foundation in partnership with the anal cancer patient community is amplifying the patient voice by facilitating a series of impactful roundtable conversations to underscore the patient lived experience. Methods: From March–August 2021, the Raymond Foundation convened virtual roundtable conversations and individual interviews with 171 anal cancer patients and survivors. Overarching themes from our conversations included: Barriers to earlier diagnosis and awareness, Frustration and anger by the lack of new treatment protocols, Quality of life after diagnosis, including daily distress levels leading to allostatic load. Results: 94% of patients/survivors reported lack of anal cancer awareness and prevention education that may have led to a later stage diagnosis; 93% reported feeling stigmatized with a marked decrease in quality of life post diagnosis; 90% reported feeling embarrassed when discussing their diagnosis with family and friends; 86% reported frustration and anger by the lack of new treatment options; Anxiety (81%), Fear (78%) Depression (73%) were common daily distress concerns; Reported physical effects of the disease and treatment, include Radiation Proctitis (71%) Fecal Incontinence (68%) Urinary Incontinence (65%). Less than half (44%) of patients felt empowered and comfortable advocating for themselves regarding their healthcare and treatment decisions. Conclusions: Anal cancer patients have many unmet needs–both physical and psycho-social. Their voices and lived experiences provide a roadmap to better understand these unmet needs. Based on our patient-reported outcomes research, we will continue our outreach and partnership with the anal cancer community to provide patient support, education and awareness programs and campaigns that help meet the needs of the anal cancer patient community.
Hormonal Control of Mammary Cancer: I. Estrogen and Mammotropes
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
18F-PSMA-11 PET/MRI in Prostate Adenocarcinoma With Mucinous Features
Authors: Qian Zhao, Bo Yang, Aisheng Dong, Changjing Zuo
Journal: Clinical Nuclear Medicine (2022)

Primary mucinous tumors involving the prostate gland are rare. We describe MRI and 18F-PSMA-11 PET/MRI findings in a case of prostate adenocarcinoma with mucinous features. The prostate tumor showed inhomogeneous hyperintensity on T2-weighted images due to high extracellular mucin content and inhomogeneous 18F-PSMA-11 uptake with SUVmax of 12.5. This case indicates PSMA PET imaging may be helpful for detection of this uncommon variant of prostate adenocarcinoma.
Autotransfusion.
Journal: BMJ (1967)

facture of cadmium-containing alloys, alkaline accumulators, cadmium-based pigments, or from any process where cadmium or cadmium-plated metal is heated to evolve fume.Cadmium is also used as a neutron absorber in nuclear reactors and is a constituent of some silver.polishes.Many of the workers exposed in the past to cadmium fume developed progressive dyspnoea, and some died after years of incapacity.Respiratory function tests have shown the
Are we comfortable with homelessness?
Authors: D. Hilfiker
Journal: JAMA (1989)

THE AMERICAN poet John Bishop Peale wrote: "The most tragic thing about the war was not that it made so many dead men, but that it destroyed the tragedy of death. "<sup>1</sup>Two articles in this issue of<i>JAMA</i>give evidence that the greatest loss of the 1980s is that American homelessness and poverty are no longer tragedies but the acceptable cost of our affluence. Behind the cold statistics that Breakey et al<sup>2</sup>document lies human pain we who are affluent can scarcely imagine. "Comorbidity" is the operative term. The 9.2 medical problems per homeless person, the 91% rate of Axis 1 psychiatric disorders in women, the 85% rate of substance abuse (chiefly alcohol) in men: all testify to enormous suffering, much of it preventable. What is it like to suffer even from simple diarrhea when there are no public toilets and one must walk the streets from morning
Error in Figure
Journal: JAMA Neurology (2022)

Laura T. van der Kamp, MD; Gabriel J. E. Rinkel, MD; Dagmar Verbaan, PhD; René van den Berg, MD, PhD; W. Peter Vandertop, MD, PhD; Yuichi Murayama, MD; Toshihiro Ishibashi, MD; Antti Lindgren, MD, PhD; Timo Koivisto, MD, PhD; Mario Teo, MD; Jerome St George, MD; Ronit Agid, MD; Ivan Radovanovic, MD, PhD; Junta Moroi, MD; Keiji Igase, MD, PhD; Ido R. van den Wijngaard, MD, PhD; Melissa Rahi, MD, PhD; Jaakko Rinne, MD, PhD; Johanna Kuhmonen, MD, PhD; Hieronymus D. Boogaarts, MD, PhD; George K. C. Wong, MD; Jill M. Abrigo, MD; Akio Morita, MD, PhD; Yoshiaki Shiokawa, MD, PhD; Katharina A. M. Hackenberg, MD; Nima Etminan, MD; Irene C. van der Schaaf, MD, PhD; Nicolaas P. A. Zuithoff, PhD; Mervyn D. I. Vergouwen, MD, PhD
Insect Stings—A Medical Emergency
Authors: Claude A. Frazier
Journal: JAMA (1976)

EVERY summer, especially during the month of August, a large number of people are endangered by the teeming world of insects. This is not a case of "blind guides, which strain at a gnat, and swallow a camel," for a generalized systemic reaction to a single insect sting can present a medical emergency that can result in death within 10 to 15 minutes. Since it is estimated that eight in a thousand individuals are allergic to insects and that four of these eight are severely sensitive, the potential for trouble is great. In fact, there are more fatalities annually due to insect stings or bites than to snakebites. While some people do react allergically to the various flies, mosquitoes, biting midges, wheelbugs, and the like, members of the Hymenoptera order—bees, yellow jackets, hornets, wasps, and ants—are responsible for the more serious problems. <h3>SYMPTOMS OF GENERALIZED SYSTEMIC REACTION</h3> Symptoms of a
PML/RARα Destabilization by Hyperthermia: A New Model for Oncogenic Fusion Protein Degradation?
Authors: Hsin Chieh Wu, Domitille Rérolle, Hugues de Thé
Journal: Blood Cancer Discovery (2021)

Abstract Summary: In this issue, Maimaitiyiming and colleagues demonstrate thermic stress–induced PML/RARα oncogenic fusion protein destabilization driven by corepressor aggregation. Hyperthermia synergizes with PML/RARα degradation by arsenic trioxide (ATO) and may circumvent ATO-resistance in historic acute promyelocytic leukemia patients. This novel approach could be extended to other corepressor-associated oncogenic fusion proteins. See related article by Maimaitiyiming et al., p. 388.
Intrapleural tetracycline for recurrent pneumothorax
Journal: JAMA (1991)

<h3>In Reply.—</h3> Dr Corboy disagrees with our recommendation that patients who are hospitalized and are treated with tube thoracostomy should receive intrapleural tetracycline. Rather, he maintains that patients with their first spontaneous pneumothorax should be treated with tube thoracostomy; then, if there is a recurrent pneumothorax, the patient with primary spontaneous pneumothorax should be treated surgically while the patient with secondary spontaneous pneumothorax should be treated with intrapleural tetracycline. We still maintain that patients with spontaneous pneumothorax who are treated with tube thoracostomy should receive intrapleural tetracycline. The intrapleural administration of tetracycline will decrease the likelihood of recurrence by approximately 40%. Then, if the patient has a recurrent pneumothorax after the tetracycline pleurodesis, we would agree with Dr Corboy that the patient should be subjected to thoracotomy. We would perform a thoracotomy in this situation whether the patient had a primary or a secondary spontaneous pneumothorax. Essentially the intrapleural instillation
Correction: Tumor Burden Limits Bispecific Antibody Efficacy through T-cell Exhaustion Averted by Concurrent Cytotoxic Therapy
Journal: Blood Cancer Discovery (2022)

In the original version of this article (1), there is an error in the Methods section, as well as in Fig. 3A and its accompanying legend. The correct BAC is CTD-2197P5, not RP11–1042H15. Figure 3A has been revised to show CTD-2197P5 in place of RP11–1042H15, and blue shading illustrating the genomic region spanned by this BAC has been adjusted accordingly. The errors have been corrected in the latest online HTML and PDF versions of the article. The authors regret these errors.
Prediction of Major Adverse Cardiovascular Events From Retinal, Clinical, and Genomic Data in Individuals With Type 2 Diabetes: A Population Cohort Study
Authors: Ify R. Mordi, Emanuele Trucco, Mohammad Ghouse Syed, Tom MacGillivray, Adi Nar, Yu Huang, Gittu George, Stephen Hogg, Venkatesan Radha, Vijayaraghavan Prathiba, Ranjit Mohan Anjana, Viswanathan Mohan, Colin N.A. Palmer, Ewan R. Pearson, Chim C. Lang, Alex S.F. Doney
Journal: Diabetes Care (2022)

OBJECTIVE Improved identification of individuals with type 2 diabetes at high cardiovascular (CV) risk could help in selection of newer CV risk-reducing therapies. The aim of this study was to determine whether retinal vascular parameters, derived from retinal screening photographs, alone and in combination with a genome-wide polygenic risk score for coronary heart disease (CHD PRS) would have independent prognostic value over traditional CV risk assessment in patients without prior CV disease. RESEARCH DESIGN AND METHODS Patients in the Genetics of Diabetes Audit and Research Tayside Scotland (GoDARTS) study were linked to retinal photographs, prescriptions, and outcomes. Retinal photographs were analyzed using VAMPIRE (Vascular Assessment and Measurement Platform for Images of the Retina) software, a semiautomated artificial intelligence platform, to compute arterial and venous fractal dimension, tortuosity, and diameter. CHD PRS was derived from previously published data. Multivariable Cox regression was used to evaluate the association between retinal vascular parameters and major adverse CV events (MACE) at 10 years compared with the pooled cohort equations (PCE) risk score. RESULTS Among 5,152 individuals included in the study, a MACE occurred in 1,017 individuals. Reduced arterial fractal dimension and diameter and increased venous tortuosity each independently predicted MACE. A risk score combining these parameters significantly predicted MACE after adjustment for age, sex, PCE, and the CHD PRS (hazard ratio 1.11 per SD increase, 95% CI 1.04–1.18, P = 0.002) with similar accuracy to PCE (area under the curve [AUC] 0.663 vs. 0.658, P = 0.33). A model incorporating retinal parameters and PRS improved MACE prediction compared with PCE (AUC 0.686 vs. 0.658, P &amp;lt; 0.001). CONCLUSIONS Retinal parameters alone and in combination with genome-wide CHD PRS have independent and incremental prognostic value compared with traditional CV risk assessment in type 2 diabetes.
Myocardial reperfusion with intravenous myocardial contrast echocardiography in patients with optimal coronary recanalization (TIMI 3 flow) after acute myocardial infarction Paolo Colonna, Massimo Ruscazio, Roberta Montisci, Christian Cadeddu, Giorgio Lai, Mauro Cadeddu, Raimondo Pirisi, Luigi Meloni, Sabino Iliceto. Department of Cardiovascular and Neurological Sciences, University of Cagliari, Cagliari, Italy
Journal: Journal of the American College of Cardiology (2001)
BOOK REVIEWS
Authors: L. M. SIGMAN
Journal: JNCI Journal of the National Cancer Institute (1992)

BOOK REVIEWS Cancer—A Colour Atlas Jeffrey S. Tobias , Christopher J. Williams . Philadelphia : J. B. Lippincott , 1991 . 940 pp., illus. $129.50 LAWRENCE M. SIGMAN LAWRENCE M. SIGMAN Stapeley Medical Office Bldg. Ste. 102, 7602 Central Ave., Philadelphia, PA 19111 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 7, April 1992, Page 532, https://doi.org/10.1093/jnci/84.7.532 Published: 01 April 1992
Cutting-balloon versus balloon alone for the treatment of in-stent restenosis: An intravascular ultrasound study Andrea S. Abizaid, Alexandre Abizaid, Alexandre Assad, Fausto Feres, Ibraim M. Pinto, Luis A. Mattos, Luis F. Tanajura, Aurea Chaves, Marinella Centemero, Rodolfo Staico, Ana C. Seixas, Amanda G. M.R. Sousa, Eduardo Sousa. Instituto Dante Pazzanese de Cardiologia, Sao Paulo, Brazil
Journal: Journal of the American College of Cardiology (2001)
Exosomes in the hypoxic TME: from release, uptake and biofunctions to clinical applications
Authors: Guangpeng He, Xueqiang Peng, Shibo Wei, Shuo Yang, Xinyu Li, Mingyao Huang, Shilei Tang, Hongyuan Jin, Jiaxing Liu, Sheng Zhang, Hongyu Zheng, Qing Fan, Jingang Liu, Liang Yang, Hangyu Li
Journal: Molecular Cancer (2022)

Abstract Hypoxia is a remarkable trait of the tumor microenvironment (TME). When facing selective pressure, tumor cells show various adaptive characteristics, such as changes in the expression of cancer hallmarks (increased proliferation, suppressed apoptosis, immune evasion, and so on) and more frequent cell communication. Because of the adaptation of cancer cells to hypoxia, exploring the association between cell communication mediators and hypoxia has become increasingly important. Exosomes are important information carriers in cell-to-cell communication. Abundant evidence has proven that hypoxia effects in the TME are mediated by exosomes, with the occasional formation of feedback loops. In this review, we equally focus on the biogenesis and heterogeneity of cancer-derived exosomes and their functions under hypoxia and describe the known and potential mechanism ascribed to exosomes and hypoxia. Notably, we call attention to the size change of hypoxic cancer cell-derived exosomes, a characteristic long neglected, and propose some possible effects of this size change. Finally, jointly considering recent developments in the understanding of exosomes and tumors, we describe noteworthy problems in this field that urgently need to be solved for better research and clinical application.
Mental Retardation, Absence of Patellae, and Other Malformations with Chromosomal Mosaicism
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Guidance of long stent implantation by intravascular ultrasound has a significantly better outcome compared to implantation guided by angiography alone: Final results of a randomized study (the TULIP study) Pranobe V. Oemrawsingh, Martin J. Schalij, Ernst E. van der Wall. Leiden University Medical Center, Leiden, The Netherlands
Journal: Journal of the American College of Cardiology (2001)
Differentiation of Reactive Lymph Nodes and Tumor Metastatic Lymph Nodes With 68Ga-FAPI PET/CT in a Patient With Squamous Cell Lung Cancer
Authors: Qihang Shang, Long Zhao, Yizhen Pang, Tinghua Meng, Haojun Chen
Journal: Clinical Nuclear Medicine (2022)

False-positive findings of mediastinal lymph node often confound the image interpretation of the preoperative PET/CT in non-small cell lung cancer. In this case, we reported 18F-FDG and 68Ga-FAPI PET/CT findings in a patient with squamous cell lung cancer. 18F-FDG-based TNM stage was stage IIIA (T1bN2M0) due to increased uptake in the enlarged right lower paratracheal lymph node. However, no abnormal 68Ga-FAPI uptake was observed in this lymph node. Subsequent histopathological examination revealed no evidence of malignancy in the mediastinal lymph nodes. Therefore, the tumor stage was downstaged to stage IA (T1bN0M0), which was in accordance with 68Ga-FAPI-based TNM stage.
Transurethral Resection
Authors: David Gomberg
Journal: JAMA (1980)

This short, clear volume on transurethral resection is an appeal basically to British urologists and surgeons to perform more transurethral resections. As a result, John Blandy has presented a valuable work for the urology resident who is beginning his transurethral work. The illustrations and explanations are clear. The chapter on instruments and equipment is excellent. The historical narrative should be of interest to the young urologist. It made me feel a great appreciation for the advances in urology from the time I first learned transurethral resection from Dr Nathaniel G. Alcock, one of the pioneers in the procedure. I was surprised that Dr Alcock's name was not mentioned, as he also developed the three-way catheter. The chapter on transurethral resection of bladder tumors is the best that I have seen, although I think that his approach is bold and not as generally accepted as he states. There are several areas