tbuckley/cabot-search huggingface dataset:
Ventricular diastolic pressure-volume relations and the pericardium. Effects of changes in blood volume and pericardial effusion in dogs.
Authors: HRefsum, MJünemann, M JLipton, CSkiöldebrand, ECarlsson, J VTyberg
Journal: Circulation (1981)

We investigated the role of the pericardium in the mechanism of shifts in the left ventricular (LV) diastolic pressure-volume relation produced by changes in circulating blood volume and by pericardial effusion. Twelve closed-chest anesthetized dogs were instrumented with pericardial and pleural balloons and intracardiac catheters for pressure measurements. We measured the volumes of the pericardium and the left and right ventricles by computed tomography (CT), integrating the area of CT cross-sections measured at 1-cm intervals from the cardiac apex to the aortic arch. The volumes of the pericardium and the cardiac chambers were changed by infusing 40 and 80 ml of dilute contrast medium into the pericardial space, by bleeding, and by rapidly infusing saline intravenously. Pericardial effusions of 80 ml reduced mean right ventricular volumes to 59% of control, whereas LV volumes were less severely compromised (81% of control). Total pericardial volume and pressure increased. Intravenous saline infusions, ...
Extracellular ATP induces immediate-early gene expression but not cellular hypertrophy in neonatal cardiac myocytes.
Authors: J SZheng, M OBoluyt, LO'Neill, M TCrow, E GLakatta
Journal: Circulation Research (1994)

It is well-documented that norepinephrine (NE) induces the expression of immediate-early genes (IEGs), such as c-fos, c-jun, and jun-B, in cultured neonatal heart cells and leads to cell growth without cell division (ie, hypertrophy). Although purinergic receptors activated by ATP are present on cardiac myocytes and ATP is coreleased with NE from sympathetic nerve endings within the heart, the potential role of the purinergic system in the cascade of events that leads to cardiac hypertrophy is unknown. We report in the present study that stimulation of purinergic receptors by micromolar concentrations of extracellular ATP increased the levels of c-fos and jun-B mRNA as well as FOS and JUN-B proteins in neonatal cardiac myocytes. The magnitude of response to micromolar ATP was comparable to that elicited by NE. The increase in IEG expression induced by ATP was preceded by a rapid transient increase in cytosolic Ca2+. Pretreatment of myocytes with the intracellular Ca2+ chelator BAPTA-AM prevented the ATP-s...
Mesenteric hemodynamics in early experimental renal hypertension in dogs.
Authors: GSimon, M BPamnani, J FDunkel, H WOverbeck
Journal: Circulation Research (1975)

To investigate mesenteric hemodynamics in early perinephritic hypertension, we measured blood flows and intravascular pressures in innvervated, collateral-free, naturally perfused loops of ileum in 50 male mongrel dogs anesthetized with sodium pentobarbital. In addition, we studied venous pressure-volume relationships in temporarily occluded segments of mesenteric veins in vivo and in excised segments of mesenteric veins in vitro. In 10 dogs (group H-1), one kidney was wrapped in silk 11 days before study; in 15 other dogs (group H-2), one kidney was wrapped 4 weeks before study and the other was removed 2 weeks before study. Twenty-five additional dogs were prepared as normotensive controls: in 10 one kidney was sham-wrapped (group C-1), and in 15 one kidney was sham-wrapped and the other was removed (group C-2). A significant rise in mean arterial blood pressure occurred in groups H-1 and H-2. Compared to controls, (1) ileal blood flow in the hypertensive dogs (H-1 plus H-2) was increased by 17% (P smal...
NEW ANTITUBERCULOSIS DRUGS
Authors: A DE PAULA
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Potential Areas of Interest in a Trial of Sorafenib Plus Hepatic Arterial Infusion of Oxaliplatin, Fluorouracil, and Leucovorin for Hepatocellular Carcinoma—In Reply
Authors: MinKe He, QiJiong Li, Ming Shi
Journal: JAMA Oncology (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Facemasks and Hand Hygiene to Prevent Influenza Transmission in Households
Authors: Benjamin J. Cowling, Kwok-Hung Chan, Vicky J. Fang, Winnie Wai, Joey Sin, Wing Hong Seto, Raymond Yung, Ming Chi Chiu, Hoi Che Lee, Timothy M. Uyeki, Peter M. Houck, Gabriel M. Leung
Journal: Annals of Internal Medicine (2020)

Few data are available on the effectiveness of nonpharmaceutical interventions for preventing influenza virus transmission. In this cluster randomized trial of 259 people with confirmed influenza v...
Risk of acute arterial and venous thromboembolic events in eosinophilic granulomatosis with polyangiitis (Churg–Strauss syndrome)
Authors: Alessandra Bettiol, Renato Alberto Sinico, Franco Schiavon, Sara Monti, Enrica Paola Bozzolo, Franco Franceschini, Marcello Govoni, Claudio Lunardi, Giuseppe Guida, Giuseppe Lopalco, Giuseppe Paolazzi, Angelo Vacca, Gina Gregorini, Pietro Leccese, Matteo Piga, Fabrizio Conti, Paolo Fraticelli, Luca Quartuccio, Federico Alberici, Carlo Salvarani, Silvano Bettio, Simone Negrini, Carlo Selmi, Savino Sciascia, Gabriella Moroni, Loredana Colla, Carlo Manno, Maria Letizia Urban, Alfredo Vannacci, Maria Rosa Pozzi, Paolo Fabbrini, Stefano Polti, Mara Felicetti, Maria Rita Marchi, Roberto Padoan, Paolo Delvino, Roberto Caporali, Carlomaurizio Montecucco, Lorenzo Dagna, Adriana Cariddi, Paola Toniati, Silvia Tamanini, Federica Furini, Alessandra Bortoluzzi, Elisa Tinazzi, Lorenzo Delfino, Iuliana Badiu, Giovanni Rolla, Vincenzo Venerito, Florenzo Iannone, Alvise Berti, Roberto Bortolotti, Vito Racanelli, Guido Jeannin, Angela Padula, Alberto Cauli, Roberta Priori, Armando Gabrielli, Milena Bond, Martina Tedesco, Giulia Pazzola, Paola Tomietto, Marco Pellecchio, Chiara Marvisi, Federica Maritati, Alessandra Palmisano, Christian Dejaco, Johann Willeit, Stefan Kiechl, Iacopo Olivotto, Peter Willeit, Domenico Prisco, Augusto Vaglio, Giacomo Emmi
Journal: European Respiratory Journal (2021)

<b>Eosinophilic granulomatosis with polyangiitis is associated with a high risk of acute arterial and venous thromboembolic events (AVTE), particularly around the time of diagnosis and in patients with high disease activity or history of previous AVTE</b>http://bit.ly/3sKnvzQ
Acute and long-term effects of vasodilator therapy on resting and exercise hemodynamics and exercise tolerance.
Authors: B MMassie, BKramer, FHaughom
Journal: Circulation (1981)

The acute hemodynamic response to vasodilators in patients with chronic heart failure has been well characterized, but less is known about the long-term hemodynamic effects of vasodilator therapy. We measured hemodynamic variables at rest and during upright exercise in 11 patients during the initiation of therapy with oral hydralazine and sublingual isosorbide dinitrate and, in eight of these, after 3 months of continuous treatment. Marked initial increases in resting cardiac output and stroke volume and reductions in wedge pressure were sustained during chronic therapy. Similarly, the early improvement in exercise hemodynamic measurements persisted in most subjects. Exercise tolerance, quantified as the maximum duration of treadmill exercise, increased modestly (7.7 +/- 2.6 to 8.9 +/- 3.3 minutes, 0.05 less than p less than 0.10) after several days on vasodilators and further (10.2 +/- 3.7 minutes, p less than 0.01) during long-term treatment. The acute hemodynamic effects of vasodilator therapy at rest ...
Chronic beta-adrenoceptor blockade prevents the development of beta-adrenergic subsensitivity in experimental right-sided congestive heart failure in dogs.
Authors: C SLiang, R PFrantz, MSuematsu, SSakamoto, J TSullebarger, T MFan, LGuthinger
Journal: Circulation (1991)

BACKGROUNDThe reductions of myocardial beta-adrenergic receptor density and responsiveness to catecholamines in congestive heart failure are associated with excessive sympathetic stimulation. The purpose of this study was to determine whether the myocardial changes could be prevented by beta-receptor blockade.METHODS AND RESULTSWe administered the oral beta-receptor blocking agent nadolol (40 mg/day) to dogs during an early stage of experimental right heart failure and to sham-operated dogs for 5 weeks. Animals receiving no nadolol were studied concurrently. Nadolol treatment did not prevent right ventricular hypertrophy or elevated concentrations of plasma norepinephrine that occurred in right heart failure, nor did it affect the decrease in myocardial norepinephrine content and norepinephrine uptake activity, suggesting that the hemodynamic stress imposed on the right ventricle of dogs with right heart failure was similar regardless of the presence or absence of beta-receptor blockade. Resting heart rat...
Targeting autophagy in ischemic stroke: From molecular mechanisms to clinical therapeutics
Authors: Amir Ajoolabady, Shuyi Wang, Guido Kroemer, Josef M. Penninger, Vladimir N. Uversky, Domenico Pratico, Nils Henninger, Russel J. Reiter, Askiel Bruno, Kaumudi Joshipura, Hamid Aslkhodapasandhokmabad, Daniel J. Klionsky, Jun Ren
Journal: Pharmacology & Therapeutics (2021)
Toxic myocarditis in paracetamol poisoning.
Authors: R A Wakeel, H T Davies, J D Williams
Journal: BMJ (1987)

Une observation: jeune fille de 15 ans morte 80 h apres ingestion d'une dose non precisee de paracetamol. L'autopsie montre une congestion des poumons, un ventricule gauche dilate et une necrose du myocarde
N-dimethylisopropyl propranolol. Effects on myocardial oxygen demands.
Authors: E GOlson, A VGoodyer, R ALangou, L SCohen, SWolfson
Journal: Circulation (1976)

N-Dimethylisopropyl propranolol (DMP) is a quaternary derivative which lacks significant beta-adrenergic blocking and local anesthetic effects. It has been reported, nonetheless, to be effective in treating experimental arrhythmias and in limiting the extent of ST-segment elevations following experimental coronary occlusion. The present study examined the effects of DMP on the hemodynamics and myocardial oxygen demands of anesthetized dogs. After a single dose of 3 mg/kg, heart rate fell from 146 +/- 8 to 124 +/- 6 beats/min (P less than 0.0025), and aortic systolic pressure fell from 151 +/- 11 to 141 +/- 9 mm Hg (0.05 less than P less than 0.10), resulting in a 16.8% reduction in the tension-time index. Stroke volume was reduced by 10% despite a 54% increase in left ventricular end-diastolic pressure, suggesting a negative inotropic effect. This was supported by a decrease in maximum extrapolated contractile element velocity from 9.10 +/- 1.05 to 6.61 +/- 65 units/sec (P less than 0.0025). Myocardial ox...
Collagen loss in the stunned myocardium.
Authors: R HCharney, STakahashi, MZhao, E HSonnenblick, CEng
Journal: Circulation (1992)

BACKGROUNDThis study was performed to biochemically assess and quantify the previously observed ultrastructural alterations in the collagen matrix of stunned myocardium.METHODS AND RESULTSThe stunned myocardium was produced in 13 mongrel dogs by a series of 12 coronary artery occlusions of 5 minutes followed by 10-minute reperfusion periods, with a final reperfusion period of 90 minutes. Regional systolic function in the stunned myocardium was 17% of control. Relative end-diastolic length in the stunned region increased up to 8%. There was a nonuniform transmural loss of collagen. Hydroxyproline in the stunned endocardium was not different from control. The stunned midwall and epicardium demonstrated 12.5% (p less than 0.05) and 14.6% (p less than 0.005) decreases, respectively. All transmural layers in the stunned myocardium had significant increases in collagenase activity before procollagenase activation, averaging a 73.6% increase (p less than 0.025). Complete activation of all procollagenase forms wi...
The law on cardiovascular devices: the role of the Food and Drug Administration and physicians in its implementation.
Authors: S HRahimtoola, G ARahmoeller
Journal: Circulation (1980)

The Medical Device Amendments of 1976 gave the Food and Drug Administration (FDA) new authority to regulate all medical devices. This regulation requires that manufacturers provide data supporting the safety and effectiveness of new and modified devices before marketing them, and eventually provide similar data even for devices now on the market. Those working in the cardiovascular field use a device every day of their professional lives; therefore, the Medical Device Amendments will have a significant effect on everyone in the field. We must understand the law so that we can provide scientific guidance to the FDA and to the medical device industry; in this article we aim to provide the necessary information.
Surface staining and cytotoxic activity of heat-shock protein 60 antibody in stressed aortic endothelial cells.
Authors: QXu, GSchett, C SSeitz, YHu, R SGupta, GWick
Journal: Circulation Research (1994)

Heat-shock protein (hsp) expression can be induced by high temperature, exposure to cytokines or oxygen radicals, ischemia, hemodynamic overload, or viral infections. To determine whether surface expression of hsp60 occurs in aortic endothelial cells stressed by high temperature or cytokines, cells from rat aortas were cultivated and stained with several types of monoclonal antibodies against hsp60. Other antibodies, eg, those against intercellular adhesion molecule-1 (ICAM-1), or immune response-associated antigens were also used as controls. Positive staining of endothelial cells on the surface and in the cytoplasm was observed after pretreatment of the cells with cytokine-containing medium, tumor necrosis factor-alpha (TNF-alpha), or interleukin-1 alpha and labeling with a specific monoclonal antibody against hsp60 (II-13). Fluorescence-activated cell sorter analyses showed that over 80% of living endothelial cells stressed by cytokine-containing medium, by TNF-alpha, or at 42 degrees C, but not by int...
Cerebral vasoconstriction during head-upright tilt-induced vasovagal syncope. A paradoxic and unexpected response.
Authors: B PGrubb, GGerard, KRoush, PTemesy-Armos, PMontford, LElliott, HHahn, PBrewster
Journal: Circulation (1991)

BACKGROUNDTo determine the effect of vasovagally mediated syncope on the cerebral circulation, transcranial Doppler sonography was used to assess changes in cerebral blood flow velocity during head-upright tilt-induced syncope.METHODS AND RESULTSThirty patients (17 men and 13 women; mean age, 43 +/- 22 years) with recurrent unexplained syncope were evaluated by use of an upright tilt-table test for 30 minutes, with or without an infusion of intravenous isoproterenol (1-4 micrograms/min), in an attempt to provoke bradycardia, hypotension, or both. Transcranial Doppler sonography was used to assess middle cerebral artery systolic velocity (Vs), diastolic velocity (Vd), ratio of systolic to diastolic velocities, pulsatility index (PI = Vs-Vd/Vmean), and resistance index (RI = Vs-Vd/Vs) before, during, and after tilt. Syncope occurred in six patients (20%) during the baseline tilt and 14 (46%) during isoproterenol infusion (total positives, 66%). In the tilt-positive patients, concomitant with the development...
Evidence for the association of unexplained pulmonary hypertension in children with the major histocompatibility complex.
Authors: R JBarst, E RFlaster, AMenon, MFotino, J HMorse
Journal: Circulation (1992)

BACKGROUNDA link between primary pulmonary hypertension (PPH) and autoimmune disorders has been postulated. To investigate this relation, we performed immunofluorescent antinuclear antibody tests (ANA) and serological human leukocyte antigen (HLA)-A, B, C, DR, and DQ typing on two groups of Caucasian children with unexplained pulmonary hypertension (PHT) and their parents.METHODS AND RESULTSGroup 1 consisted of 17 children with PPH including two patients with familial PPH and three patients with trivial congenital pulmonary to systemic communications. Group 2 consisted of 13 children with advanced PHT and anatomically large congenital pulmonary to systemic communications (PHT + shunt). Both groups had comparably severe pulmonary vascular disease documented by cardiac catheterization. The following statistically significant data (p less than 0.05) were obtained when the study groups were compared with those published for normal controls. Although positive ANAs and varying titers of autoantibodies were foun...
Thallium 201 kinetics in stunned myocardium characterized by severe postischemic systolic dysfunction.
Authors: C AMoore, JCannon, D DWatson, SKaul, G ABeller
Journal: Circulation (1990)

The hypothesis tested in this study was that despite the presence of severe postischemic myocardial dysfunction (stunning), the extraction and subsequent intracellular washout of thallium 201 should be preserved as long as irreversible sarcolemmal membrane injury was avoided. To produce myocardial stunning, 19 open-chested dogs with a critical left anterior descending coronary artery (LAD) stenosis underwent 10 5-minute periods of total LAD occlusion, each interspersed by 10 minutes of reperfusion by reflow through the critical stenosis. In another 12 control dogs observed for the same time period, no LAD occlusions were performed after placement of the critical stenosis. Hemodynamics, regional myocardial thickening by quantitative two-dimensional echocardiography, and microsphere-determined regional blood flows were serially measured. In 18 stunned dogs, systolic thickening in the LAD zone was markedly reduced to 0.4 +/- 2.4% at 40 minutes after the 10th reperfusion period compared with 32.5 +/- 2.2% t...
Longitudinal propagation of contraction in the isolated conduit coronary arteries of humans and pigs.
Authors: HAraki, NSakaino, NFurusho, KNishi
Journal: Circulation Research (1989)

We examined the longitudinal propagation of contraction in isolated human and pig coronary arteries. Epicardial coronary arteries of about 2 cm were cut open longitudinally, and the tension development of circular muscles was measured simultaneously at three sites (both cut ends and the midportion of the segment). Cyclic tension changes arising at one site of human coronary artery propagated smoothly to the other sites, and the whole length of segment worked as a single unit. Contraction induced by locally applied prostaglandin F2 alpha or histamine also propagated in four of seven preparations. The remaining three human and all seven pig coronary arteries showed propagation of such drug-induced contraction after treatment with 10 mM tetraethylammonium (TEA). In pig coronary arteries treated with TEA, electrical stimulation evoked a reproducible local contraction and its propagation. Propagation velocity was 9.0 +/- 0.7 at 0.8 mM calcium concentration and increased to 11.1 +/- 0.9 and 13.1 +/- 1.4 mm/sec ...
Evaluation of left ventricular contractile performance utilizing end-systolic pressure-volume relationships in conscious dogs.
Authors: M TSodums, F RBadke, M RStarling, W CLittle, R AO'Rourke
Journal: Circulation Research (1984)

The relationship between left ventricular end-systolic pressure and volume has been proposed as a model of left ventricular contraction which may be useful for quantifying inotropic state independent of preload and afterload. Although the model has been well-validated in isolated hearts, systematic evaluation in conscious animals with an intact peripheral circulation has been limited. Accordingly, we derived end-systolic pressure-volume relationships in twelve conscious dogs, chronically instrumented to measure left ventricular pressure and dimensions from endocardial ultrasonic crystals in three orthogonal axes. We examined the linearity of the end-systolic pressure-volume relationship, its response to alterations of inotropic state and the peripheral circulation, and the influence of beta-adrenergic reflexes. End-systolic pressure-volume relationships were constructed by linear regression of end-systolic pressure-volume coordinates produced by transient inferior vena caval occlusions during atrial pacin...
Single-passage extraction and permeability estimation of sodium in normal dogs lungs.
Authors: TYipintsoi
Journal: Circulation Research (1976)

Bolus injections of 24NaCl, 131I-albumin, and indocyanine green dye were made into the right atria of anesthetized, ventilated dogs. Blood was sampled from the femoral artery, and from the dilution curves, instantaneous extractions, E2(t), and area averaged extractions, E3(t), were calculated for sodium at various plasma flows (Fp). Flow reduction was produced by transient inferior vena cava obstruction. E2(t) and E3(t) within any dilution curve generally started off with a high value, then decreased with time. The E3 that occurred at the peak of the albumin-dilution curve were about 0.11 for plasma flow of 0.75 liter/min and tended to decrease as flow increased. Parallel study of the sodium extravascular space at equilibrium gave values of 0.3-0.4 g of plasma sodium per g of tissue, suggesting that this volume is not infinitely small. Since the E was low it is unlikely that the high initial E(t) and the decreasing E(t) were due to early back flux. Calculation of capillary permeability surface area produc...
129P Predicting response to immunotherapy in advanced non-small cell lung cancer
Authors: M. Rebordão Pires, C. Amorim Costa, T. Cunha Pereira, J.C. Monteiro, I. Domingues, A.C. Caetano, A.R. Meira Garcia, E. Jesus, G. Sousa
Journal: Journal of Thoracic Oncology (2021)