tbuckley/cabot-search huggingface dataset:
World Tuberculosis Day 2022: aligning COVID-19 and tuberculosis innovations to save lives and to end tuberculosis
Authors: Francine Ntoumi, Jean B Nachega, Eleni Aklillu, Jeremiah Chakaya, Irina Felker, Farhana Amanullah, Dorothy Yeboah-Manu, Kenneth G Castro, Alimuddin Zumla
Journal: The Lancet Infectious Diseases (2022)
StatBite Prostate Cancer U.S. Mortality Rate 2000-2008
Journal: JNCI Journal of the National Cancer Institute (2011)

Prostate cancer is a form of cancer that develops in the prostate gland of the male reproductive system.Most prostate cancers are slow growing; however, in some cases the cancer is more aggressive.This data reflects the mortality rate per 100,000 males of all ages in the U.S. from 2000-2008.
Response to Comment on Gange et al. Incidence of Proliferative Diabetic Retinopathy and Other Neovascular Sequelae at 5 Years Following Diagnosis of Type 2 Diabetes. Diabetes Care 2021;44:2518–2526
Authors: Jennifer Lopez, William S. Gange, Khristina Lung, Benjamin Y. Xu, Seth A. Seabury, Brian C. Toy
Journal: Diabetes Care (2022)
Evidence for an age cut-off greater than 365 days for neuroblastoma risk group stratification in the Children’s Oncology Group (COG)
Authors: W. B. London, R. P. Castleberry, K. K. Matthay, A. T. Look, R. C. Seeger, H. Shimada, P. Thorner, B. Garrett, J. M. Maris, C. P. Reynolds, S. L. Cohn
Journal: Journal of Clinical Oncology (2005)

8500 Background: In the Children’s Oncology Group, risk group assignment for neuroblastoma is critical for therapeutic decisions, and stratified by INSS stage, MYCN status, ploidy, Shimada histopathology, and diagnosis age. Age <365 days has been associated with favorable outcome, but recent studies suggest older age cut-off may improve prognostic precision. Methods: To identify the optimal age cut-off, we retrospectively analyzed data from the Pediatric Oncology Group biology study 9047 and Children’s Cancer Group studies 321p1-p4, 3881, 3891, and B973 on 3,666 patients (1986–2001) with documented ages and follow-up data. Twenty-seven separate analyses, one for each different age cut-off (adjusting for MYCN and stage), tested age influence on outcome. The cut-off that maximized outcome difference between younger and older patients was selected. Results: Thirty-seven percent of patients were <365 days and 64% were ≥365 days old (4-year EFS rate±SE: 83%±1% [n=1,339] and 45%±1% [n=2,327], respectively [p<0.0001]). Median follow-up time was 5.8 years. Graphical analyses revealed the continuous nature of the prognostic contribution of age to outcome. The optimal 460-day cut-off we selected maximized the outcome difference between younger and older patients. Forty-three percent were <460 days and 57% were ≥460 days old (4-year EFS rate±SE: 82%±1% [n=1,589] and 42%±1% [n=2,077], respectively [p<0.0001]). Using a 460-day cut-off (assuming stage 4, MYCN-amplified patients remain high-risk), 5% of patients (365–460 days: 4-year EFS 92%±3%, n=135) fell into a lower risk group. Conclusions: The prognostic contribution of age to outcome is continuous in its nature. Within clinically relevant risk stratification, statistical support exists for an age cut-off of 460 days. No significant financial relationships to disclose.
THE MENINGOCOCCUS OF WEICHSELBAUM
Authors: E. C. Hort
Journal: BMJ (1917)

The Teaching of Recent Experimental Resedreh.NOTWITHSTANDING the results of recent experimental research, it is still taught, and it.is in consequence 'videly believed, that tile meninaococcus of Weichselbaum iu itself the direct causal agent of thlat form of epidemic cerebro-spinal fever which is sometimes spoken of as imeningocoecal meningitis.It is also still taught, and the teaching is accepted without question, that the meningococcus, as one of the "lower" bacteria, is an organism with an extremely simple life-cycle, which begins and ends with binary fission into two equal parts.A meningococcus-so runs the legend-always arises directly from a meningococcus, and in' no other way.As regards the first of tl]ese propositions-tllat the meningococcus is itself tlle direct cause of the disease wvhich bears its name-I showed by experiment in 1915, and this, in conjunction witlh Captain A. I. Caulfeild, I amply coinfirmed in the following year:1.That cultures of the meningococcus -in cerebro-spinal fluid or in suitable laboratory" media frequently contain a miiiute filterable virus, which is just as 'pathogenic to monikeys (tlhouglh itlt necessarily productive of meningitis) as are unfiltered cuiltures.
A New Imaging Technique Can Directly Assess Tumor Vaccine Responses
Journal: Cancer Discovery (2011)

Abstract Major finding: [18F]FLT PET allows visualization of antigen-specific immune responses to DC therapy. Impact: Responders can be discriminated from non-responders after anti-cancer vaccination. Strategy: Proliferating immune cells selectively take up and retain [18F]FLT to allow in vivo imaging.
Designer Extracellular Vesicles Modulate Pro‐Neuronal Cell Responses and Improve Intracranial Retention (Adv. Healthcare Mater. 5/2022)
Authors: Lilibeth Ortega‐Pineda, Alec Sunyecz, Ana I. Salazar‐Puerta, Maria Angelica Rincon‐Benavides, Diego Alzate‐Correa, Amrita Lakshmi Anaparthi, Elizabeth Guilfoyle, Louisa Mezache, Heather L. Struckman, Silvia Duarte‐Sanmiguel, Binbin Deng, David W. McComb, Daniel J. Dodd, William R. Lawrence, Jordan Moore, Jingjing Zhang, Eduardo Reátegui, Rengasayee Veeraraghavan, M. Tyler Nelson, Daniel Gallego‐Perez, Natalia Higuita‐Castro
Journal: Advanced Healthcare Materials (2022)

Functionalized Extracellular Vesicles In article number 2100805 by Natalia Higuita-Castro and co-workers, designer extracellular vesicles (EVs) are manufactured via non-viral engineering of donor cells through electroporation. Designer EVs are packed with plasmid DNA, mRNA, and protein content. Transfecting donor cells with expression plasmids for membrane proteins can be used to tailor the surface decoration of the EVs. Pro-neurogenic designer EVs drive neurogenesis and improve targeting of neuronal tissue, in vitro and in vivo.
Chronic Pain
Authors: Cathy M. Russo, William G. Brose
Journal: Annual Review of Medicine (1998)

Chronic pain is an emotional experience and is defined as pain lasting greater than six months. It is important to understand the neurophysiology of pain in order to treat it. Nociceptors in the periphery travel to the substantia gelatinosa of the spinal cord while secondary and tertiary afferents transmit information from the dorsal horn to the brain. Modification of pain information may take place in these ascending pathways or in descending pathways. Treatment of chronic pain is most successful when it is approached in a multidisciplinary fashion with the focus not only on treatment of underlying etiology, but also on the secondary impacts of pain on the patient's life. The management of chronic pain requires special expertise. Most of the experts in chronic pain assessment and management organize themselves into pain treatment centers. These centers vary widely in their approach to the problem. The most sophisticated is a multidisciplinary center that is university-based and includes teaching and research. Treatment of chronic pain includes a variety of medications, psychological support, and rehabilitation. Multidisciplinary pain management is also an integral part of the palliative care and hospice concept used to treat cancer pain.
Understanding and Communicating Uncertainty in Achieving Diagnostic Excellence
Authors: Maria R. Dahm, Carmel Crock
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Patterns and Trends in Receipt of Opioids Among Patients Receiving Treatment for Cancer in a Large Health System
Authors: Lindsay M. Sabik, Kirsten Y. Eom, Zhaojun Sun, Jessica S. Merlin, Hailey W. Bulls, Patience Moyo, Jennifer A. Pruskowski, G.J. van Londen, Margaret Rosenzweig, Yael Schenker
Journal: Journal of the National Comprehensive Cancer Network (2022)

Given limited evidence on opioid prescribing among patients receiving treatment for cancer during the ongoing opioid epidemic, our objective was to assess predictors of and trends in opioid receipt during cancer treatment, including how patterns differ by type of cancer. Using cancer registry data, we identified patients with a first lifetime primary diagnosis of breast, colorectal, or lung cancer from 2013 to 2017 who underwent treatment within a large cancer center network. Cancer registry data were linked to electronic health record information on opioid prescriptions. We examined predictors of and trends in receipt of any opioid prescription within 12 months of cancer diagnosis. The percentage of patients receiving opioids varied by cancer type: breast cancer, 35% (1,996/5,649); colorectal, 37% (776/2,083); lung, 47% (1,259/2,654). In multivariable analysis, opioid use in the year before cancer diagnosis was the factor most strongly associated with receipt of opioids after cancer diagnosis, with 4.90 (95% CI, 4.10-5.86), 5.09 (95% CI, 3.88-6.69), and 3.31 (95% CI, 2.68-4.10) higher odds for breast, colorectal, and lung cancers, respectively. We did not observe a consistent decline in opioid prescribing over time, and trends differed by cancer type. Our findings suggest that prescription of opioids to patients with cancer varies by cancer type and other factors. In particular, patients are more likely to receive opioids after cancer diagnosis if they were previously exposed before diagnosis, suggesting that pain among patients with cancer may commonly include non-cancer-related pain. Heterogeneity and complexity among patients with cancer must be accounted for in developing policies and guidelines aimed at addressing pain management while minimizing the risk of opioid misuse.
<i>Bifidobacterium longum</i> mediated tryptophan metabolism to improve atopic dermatitis via the gut-skin axis
Authors: Zhifeng Fang, Tong Pan, Lingzhi Li, Hongchao Wang, Jinlin Zhu, Hao Zhang, Jianxin Zhao, Wei Chen, Wenwei Lu
Journal: Gut Microbes (2022)

Gut microbial disturbance affects allergic diseases including asthma, atopic dermatitis (AD) via the aberrant immune response. Some Bifidobacterial species and strains have been reported to improve AD via modulating immune-microbe interactions in patients. However, the effective metabolites and mechanism of alleviating AD in bifidobacteria remain to be elucidated. This study aimed to explore the microbial metabolite and mechanism of Bifidobacterium longum to improve AD. Based on shotgun metagenomic sequencing and UHPLC Q-Exactive-MS targeted metabolic experiments in vitro and in vivo, we focused on tryptophan metabolism and indole derivatives, which are endogenous ligands for aryl hydrocarbon receptor (AHR). Indole-3-carbaldehyde (I3C), a tryptophan metabolite of B. longum CCFM1029 activated AHR-mediated immune signaling pathway to improve AD symptoms in animal and clinical experiments. B. longum CCFM1029 upregulated tryptophan metabolism and increased I3C to suppress aberrant T helper 2 type immune responses, but these benefits were eliminated by AHR antagonist CH223191. Furthermore, B. longum CCFM1029 reshaped gut microbial composition in AD patients, increased fecal and serum I3C, and maintained the abundance of Lachnospiraceae related to tryptophan metabolism of gut microbiota. The results suggested that based on the interactions of the gut-skin axis, B. longum CCFM1029 upregulated tryptophan metabolism and produced I3C to activate AHR-mediated immune response, alleviating AD symptoms. Indole derivates, microbial metabolites of tryptophan, may be the potential metabolites of bifidobacteria to alleviate AD via the AHR signaling pathway.
Thermal Value of Food
Authors: W. H. O'Leary
Journal: BMJ (1868)

77,2 RI"TISH MEDICALD 7 AZL.[Aprl 4, rMi.that the uterus should not be subjected to its influence, because I feel certain that there is less mischief to be apprehended from the pain inflicted by incising the organ, than what is likely to accrue from the playing of the ether-spray on the part when the abdomen is laid open.I do not apprehend that the edges of the abdominal wound are likely to suffer in the way.Dr. Kidd (loc.cit.) states that the lips of the abdo- minal wound after ovariotomy may mortify; he says, " under ether-spray the lips of the wound, too, may mortify."In conclusion, I think I may fairly state that, although the maternal statistics of this operation present an unfavourable aspect, I am fully warranted, after a full and candid investigation of the causes of the death of the mothers, in concluding that they are not, in most of the cases, to be attributed to the operation.Some of these causes are avoidable, or preventable; some are controllable.
SUSCEPTIBILITY OF RABBITS TO INFECTION BY THE INHALATION OF VIRULENT PNEUMOCOCCI
Authors: Ernest G. Stillman, Arnold Branch
Journal: The Journal of Experimental Medicine (1926)

1. Rabbits are very susceptible to infection by inhalation of Type I pneumococci. 2. When rabbits are exposed to a pneumococcus spray the bacteria readily penetrate into the lower respiratory tract. The pneumococci which reach the periphery of the lungs as a result of this procedure usually disappear within a few hours but a generalized and fatal septicemia frequently later appears. Pneumococci may then be recovered from the periphery of the kidney, liver, and spleen. In the animals which die pleurisy and pericarditis are common but pneumonia does not occur. 3. Rabbits may recover from pneumococcus septicemia.
The British Society of Gastroenterology. 25-27 April 1984, Salford. Abstracts.
Authors: M Qamar, A Read, R Skidmore, J Evans, G Hamilton, E Hobbs
Journal: Gut (1984)

the University of Salford under the presidency of Dr R B McConnell.The scientific programme included 116 spoken communications and 46 poster communications selected by the programme committee.
Avelumab Impresses in Merkel Cell Carcinoma
Journal: Cancer Discovery (2017)

The PD-L1 inhibitor avelumab-approved by the FDA in March for the treatment of Merkel cell carcinoma-demonstrated a high number of durable responses in an international, open-label, prospective phase II study. The results of the study, which supported the FDA's decision, were presented in April at the American Association for Cancer Research (AACR) Annual Meeting 2017.
Clinical Remarks on Modified Linear Extraction
Authors: A. Von Graefe
Journal: BMJ (1867)

FROx further experience, I have still more strongly than before to urge that whatever of iris presents itself in the incision should be thoroughly excised at the level of the external wound.Where the intra- ocular pressure immediately after the operation is very moderate, small slips which were left behind at the corners, may, indeed, be caused to glide back partly by the contraction of the remaining iris, and partly by such gentle rubbing of the lids as we are familiar with from flap-extraction.This, however, cannot with certainty be relied upon; and, as a rule, the slips referred to become fixed in the wound- channel.What shall be the consequence hereof, depends on the degree of irritation, or the state of the intraocular pressure, during the period of healing, and perhaps on other less obvious circum- stances.When the secretory tendency runs high, or the ocular pressure (though perhaps still physiological), is relatively strong,t portions of iris thus fixed may come to form small prolapses which force the wound-edges asunder, and render the curvature of the neighbouring cornea irregular.They also cause an annoying sensation of pressure, and may, in
Hormonal pregnancy tests and congenital malformations.
Authors: I Gal
Journal: BMJ (1977)

with permanent injury.These injuries had usually been caused by collision with other swimmers or the side or bottom of the pool rather than by the catapult effect described.The cases described by Dr J6nasson emphasise the seriousness of injuries which may be associated with the use of this popular type of goggle which incorporates a strong elastic band.In the light of these reports the society is continuing to discourage their use during teaching sessions and proposes to seek the opinion of other organisations responsible for other aquatic activities.
index to advertisers
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Retraction: Endogenous Control of Cell Cycle Progression by Autocrine Transforming Growth Factor β in Breast Cancer Cells
Authors: Sudhakar Ammanamanchi, Manoranjani P.M. Tillekeratne, Tien C. Ko, Michael G. Brattain
Journal: Cancer Research (2019)

This article (1) has been retracted at the request of the editors. A reader informed the editors that Fig. 1 is similar to a figure in a previously published article (2). In addition, several p27, p21, and actin Western blot bands appear to have been manipulated and duplicated in Figs. 4 and 5. The first author acknowledges these manipulations and duplications but is unable to provide the original data.A copy of this Retraction Notice was sent to the last known e-mail addresses for 2 of the 4 authors. One author (S. Ammanamanchi) agreed to the retraction; one author (T.C. Ko) did not respond; and one author (M.P.M. Tillekeratne) could not be located. The corresponding author, M.G. Brattain, is deceased.
Learning From Real-world Implementation of Daily Home-Based Symptom Monitoring in Patients With Cancer
Authors: Gabrielle B. Rocque
Journal: JAMA Network Open (2022)

Bobby Daly, MD, MBA; Kevin Nicholas, MPA; Jessica Flynn, MS; Nicholas Silva, BS; Katherine Panageas, DrPH; Jun J. Mao, MD, MSCE; Lior Gazit, MS; Dmitriy Gorenshteyn, PhD; Stefania Sokolowski, MA; Tiffanny Newman, PhD; Claire Perry, BA; Isaac Wagner, MS; Alice Zervoudakis, MD; Rori Salvaggio, RN, NEA-BC; Jessie Holland, MSN, RN; Yeneat O. Chiu, MHA; Gilad J. Kuperman, MD, PhD; Brett A. Simon, MD, PhD; Diane L. Reidy-Lagunes, MD; Wendy Perchick, BA
A carcinoembryonic antigen-specific cell therapy selectively targets tumor cells with HLA loss of heterozygosity in vitro and in vivo
Authors: Mark L. Sandberg, Xueyin Wang, Aaron D. Martin, Daniel P. Nampe, Grant B. Gabrelow, Chuck Z. Li, Michele E. McElvain, Wen-Hua Lee, Sanam Shafaattalab, Sara Martire, Fernando A. Fisher, Yuta Ando, Edwin Liu, David Ju, Lu Min Wong, Han Xu, Alexander Kamb
Journal: Science Translational Medicine (2022)

The CEACAM5 gene product [carcinoembryonic antigen (CEA)] is an attractive target for colorectal cancer because of its high expression in virtually all colorectal tumors and limited expression in most healthy adult tissues. However, highly active CEA-directed investigational therapeutics have been reported to be toxic, causing severe colitis because CEA is expressed on normal gut epithelial cells. Here, we developed a strategy to address this toxicity problem: the Tmod dual-signal integrator. CEA Tmod cells use two receptors: a chimeric antigen receptor (CAR) activated by CEA and a leukocyte Ig-like receptor 1 (LIR-1)–based inhibitory receptor triggered by human leukocyte antigen (HLA)-A*02. CEA Tmod cells exploit instances of HLA heterozygous gene loss in tumors to protect the patient from on-target, off-tumor toxicity. CEA Tmod cells potently killed CEA-expressing tumor cells in vitro and in vivo. But in contrast to a traditional CEA-specific T cell receptor transgenic T cell, Tmod cells were highly selective for tumor cells even when mixed with HLA-A*02–expressing cells. These data support further development of the CEA Tmod construct as a therapeutic candidate for colorectal cancer.
Ward Design in Relation to Postoperative Wound Infection: Part II
Authors: A. I. G. Davidson, H. G. Smylie, A. Macdonald, G. Smith
Journal: BMJ (1971)

A detailed investigation has been carried out into the behaviour of wounds after 1,000 general surgical operations, about equal numbers of patients having been studied in two different ward and operating theatre environments. The wound sepsis rate was reduced after transfer to the new type of ward. It is concluded that features of the new ward environment were responsible for the observed fall in the incidence of cross-infection.
Neonatal conjunctivitis.
Authors: E I Tanner
Journal: BMJ (1972)

t size of the bacilli was 8 p x 1 it.No capsules were seen and many bacilli showed subterminal empty spaces probably representing spores which had not distended the bacterial ouline.Ty,pical rounded ends were present in all bacilli and many of them were slightly curved, others were at right angles to each other giving the impression of bnching hyphal foirns.Cultures from t-he drainage tube on the fourth postoperative day for anaerobic bacilli failed to produce any Inmiediately after receipt of the pathology report massive penicillin therapy was started with very favourable response.On the 16th postoperative day the patient was discharged after a minor lung infection had cleared up with broad specum antibiotic therapy.Liver function was normal except for slightly reduoed serum protein (5 4 g/100 mi).We were intrigued by the presence of she Grm-positive bacilli, since there was only mild bruising of the anterior abdominal wall and no bowel injury was found.Ascent of bacilli in the post-traumatic state up the common bile duct is the probable source of these organisms.Bacteria, especially anaerobes, have been found after death in human and animal livers at necropsy.1 Cultures of liver biopsies are generally negative, but this is believed to be due to the bactericidal action of fatty acids.Bacteria entering the biliary tree or the portal circula- tion from the intestine have also been re- ported.1 Experimental hepatic dame also kads to bacteria in the bile or lymph.The exact classification of these bateria was not possible because specimens for anaerobic cultures were not obtained during the surgical procedure.The morphology and gas formation would suggest Cl. welchii or orgaisms of the gas-forming anaerobic group.-Weare, etc.,