tbuckley/cabot-search huggingface dataset:
Role of epigenetics in unicellular to multicellular transition in Dictyostelium
Authors: Simon Yuan Wang, Elizabeth Ann Pollina, I-Hao Wang, Lindsay Kristina Pino, Henry L. Bushnell, Ken Takashima, Colette Fritsche, George Sabin, Benjamin Aaron Garcia, Paul Lieberman Greer, Eric Lieberman Greer
Journal: Genome biology (2021)

Abstract Background The evolution of multicellularity is a critical event that remains incompletely understood. We use the social amoeba, Dictyostelium discoideum , one of the rare organisms that readily transits back and forth between both unicellular and multicellular stages, to examine the role of epigenetics in regulating multicellularity. Results While transitioning to multicellular states, patterns of H3K4 methylation and H3K27 acetylation significantly change. By combining transcriptomics, epigenomics, chromatin accessibility, and orthologous gene analyses with other unicellular and multicellular organisms, we identify 52 conserved genes, which are specifically accessible and expressed during multicellular states. We validated that four of these genes, including the H3K27 deacetylase hdaD , are necessary and that an SMC-like gene, smcl1 , is sufficient for multicellularity in Dictyostelium . Conclusions These results highlight the importance of epigenetics in reorganizing chromatin architecture to facilitate multicellularity in Dictyostelium discoideum and raise exciting possibilities about the role of epigenetics in the evolution of multicellularity more broadly.
CARDIOPROTECTION AND PLAQUE REGRESSION WITH MEDI6012 IN ACUTE ST ELEVATION MYOCARDIAL INFARCTION - PRIMARY RESULTS OF THE REAL-TIMI 63B RANDOMIZED CLINICAL TRIAL
Authors: Marc P. Bonaca, David A. Morrow, Brian A. Bergmark, Joao A.C. Lima, Udo Hoffmann, Yoko Kato, Michael T. Lu, Julia Kuder, Sabina A. Murphy, Sami A. Omar, Andrea L. Vavere, Yi-Ting Chang, Richard T. George, Marc S. Sabatine
Journal: Journal of the American College of Cardiology (2021)
Modeling Strategies to Optimize Cancer Screening in USPSTF Guideline–Noncompliant Women
Authors: Glen B. Taksler, Elisabeth F. P. Peterse, Isarah Willems, Kevin ten Haaf, Erik E. L. Jansen, Inge M. C. M. de Kok, Nicolien T. van Ravesteyn, Harry J. de Koning, Iris Lansdorp-Vogelaar
Journal: JAMA Oncology (2021)

In 2018, only half of US women obtained all evidence-based cancer screenings. This proportion may have declined during the COVID-19 pandemic because of social distancing, high-risk factors, and fear.
Abstract 13629: Cardiovascular and Renal Outcomes With Dual Renin-Angiotensin System Blockade: A Meta-analysis
Authors: Satyanarayana R Vaidya, Santhosh R Devarapally, Benjamin Harrington, Franz H Messerli
Journal: Circulation (2017)

Introduction: Dual renin-angiotensin system (RAS) blockade with an angiotensin-converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB) has been shown to reduce hospitalization due...
Prevalence and Heterogeneity of PD-L1 Expression by 22C3 Assay in Routine Population-Based and Reflexive Clinical Testing in Lung Cancer
Authors: David M. Hwang, Tahani Albaqer, Rex C. Santiago, Jessica Weiss, Jeffrey Tanguay, Michael Cabanero, Yuki Leung, Prodipto Pal, Zanobia Khan, Sally C.M. Lau, Adrian Sacher, Emina Torlakovic, Carol Cheung, Ming-Sound Tsao
Journal: Journal of Thoracic Oncology (2021)
Is “willpower” a scientific concept? Suppressing temptation <i>contra</i> resolution in the face of adversity
Authors: Elias L. Khalil
Journal: Behavioral and Brain Sciences (2021)

The distinction that Ainslie draws among the triple-phenomena "suppression," "resolve," and "habit" is a great advance in decision making theory. But the conceptual machinery "willpower," and its underpinning distinction between small/soon (SS) rewards as opposed to large/later (LL) rewards, provides a faulty framework to understand the triple-phenomena.
Diphenhydramine protects against cisplatin-induced nephrotoxicity.
Authors: Marie Helen Hanigan, Guiyan Xu
Journal: Cancer Research (2006)

5447  Cisplatin is used as first line treatment of head and neck cancer, germ cell tumors, and as consolidation therapy for many types of tumors. Diphenhydramine (DPH, Benadryl) is included in some cisplatin-based chemotherapy protocols to prevent cisplatin-induced emesis. We have recently found DPH also protects against cisplatin-induced nephrotoxicity. Pretreatment with DPH for 1 to 3 days protected confluent cultures of renal proximal tubule cells from cisplatin toxicity. DPH was not protective when administered concurrently with cisplatin. Pretreatment with DPH did not affect intracellular cisplatin accumulation nor did it protect against the toxicity of amphotericin B, an antifungal drug, which is also toxic to the kidney. Our previous studies have shown that cisplatin kills the proximal tubule cells of the kidney via the metabolism of a cisplatin-glutathione-conjugate to a reactive thiol, a mechanism that is distinct from the anti-tumor activity of the drug. The protective effect of DPH was specific to the nephrotoxic effect of cisplatin. Pretreatment of dividing ovarian tumor cells with DPH did not alter their sensitivity to cisplatin. Dose-dependent and cumulative nephrotoxicity can limit the use of cisplatin. Clinical studies are being developed to evaluate protocols that include DPH pretreatment to prevent cisplatin-induced nephrotoxicity.
Patient and Therapy-Related Factors Affecting the Toxicity of Pegylated-Asparaginase for the Treatment of Adult Acute Lymphoblastic Leukemia
Authors: Paola Minetto, Nadia Bisso, Fabio Guolo, Marino Clavio, Elisa Coviello, Daniela Guardo, Filippo Ballerini, Maurizio Miglino, Roberto Massimo Lemoli, Marco Gobbi
Journal: Blood (2017)
IMPLICATIONS OF PERIPROCEDURAL MYOCARDIAL BIOMARKER ELEVATIONS AND COMMONLY USED MI DEFINITIONS AFTER LEFT MAIN PCI
Authors: Haoyu Wang, Bo Xu, Kefei Dou, Changdong Guan, Lei Song, Yunfei Huang, Rui Zhang, Lihua Xie, Min Zhang, Hongbing Yan, Weixian Yang, Yongjian Wu, Yuejin Yang, Shubin Qiao, Runlin Gao, Gregg W. Stone
Journal: Journal of the American College of Cardiology (2021)
SEX DIFFERENCES IN OUTCOMES OF CARDIOGENIC SHOCK REQUIRING TEMPORARY PERCUTANEOUS MECHANICAL CIRCULATORY SUPPORT
Authors: Miluska O. Mejia Trebejo, Katia Bravo Jaimes, Nadia Abelhad, Yelin Zhou, Marwan Jumean, Sriram Nathan, Abhijeet Dhoble
Journal: Journal of the American College of Cardiology (2021)
Inhibition of phosphodiesterase-4D in adults with fragile X syndrome: a randomized, placebo-controlled, phase 2 clinical trial
Authors: Elizabeth M. Berry-Kravis, Mark D. Harnett, Scott A. Reines, Melody A. Reese, Lauren E. Ethridge, Abigail H. Outterson, Claire Michalak, Jeremiah Furman, Mark E. Gurney
Journal: Nature Medicine (2021)
Functional Connectome Prediction of Anxiety Related to the COVID-19 Pandemic
Authors: Li He, Dongtao Wei, Fan Yang, Jie Zhang, Wei Cheng, Jianfeng Feng, Wenjing Yang, Kaixiang Zhuang, Qunlin Chen, Zhiting Ren, Yu Li, Xiaoqin Wang, Yu Mao, Zhiyi Chen, Mei Liao, Huiru Cui, Chunbo Li, Qinghua He, Xu Lei, Tingyong Feng, Hong Chen, Peng Xie, Edmund T. Rolls, Linyan Su, Lingjiang Li, Jiang Qiu
Journal: American Journal of Psychiatry (2021)

Objective: Increased anxiety in response to the COVID-19 pandemic has been widely noted. The purpose of this study was to test whether the prepandemic functional connectome predicted individual anxiety induced by the pandemic. Methods: Anxiety scores from healthy undergraduate students were collected during the severe and remission periods of the pandemic (first survey, February 22–28, 2020, N=589; second survey, April 24 to May 1, 2020, N=486). Brain imaging data and baseline (daily) anxiety ratings were acquired before the pandemic. The predictive performance of the functional connectome on individual anxiety was examined using machine learning and was validated in two external undergraduate student samples (N=149 and N=474). The clinical relevance of the findings was further explored by applying the connectome-based neuromarkers of pandemic-related anxiety to distinguish between individuals with specific mental disorders and matched healthy control subjects (generalized anxiety disorder, N=43; major depression, N=536; schizophrenia, N=72). Results: Anxiety scores increased from the prepandemic baseline to the severe stage of the pandemic and remained high in the remission stage. The prepandemic functional connectome predicted pandemic-related anxiety and generalized to the external sample but showed poor performance for predicting daily anxiety. The connectome-based neuromarkers of pandemic-related anxiety further distinguished between participants with generalized anxiety and healthy control subjects but were not useful for diagnostic classification in major depression and schizophrenia. Conclusions: These findings demonstrate the feasibility of using the functional connectome to predict individual anxiety induced by major stressful events (e.g., the current global health crisis), which advances our understanding of the neurobiological basis of anxiety susceptibility and may have implications for developing targeted psychological and clinical interventions that promote the reduction of stress and anxiety.
The Relationship Between Bone and Reproductive Hormones Beyond Estrogens and Androgens
Authors: Edouard G Mills, Lisa Yang, Morten F Nielsen, Moustapha Kassem, Waljit S Dhillo, Alexander N Comninos
Journal: Endocrine Reviews (2021)

Abstract Reproductive hormones play a crucial role in the growth and maintenance of the mammalian skeleton. Indeed, the biological significance for this hormonal regulation of skeletal homeostasis is best illustrated by common clinical reproductive disorders, such as primary ovarian insufficiency, hypothalamic amenorrhea, congenital hypogonadotropic hypogonadism, and early menopause, which contribute to the clinical burden of low bone mineral density and increased risk for fragility fracture. Emerging evidence relating to traditional reproductive hormones and the recent discovery of newer reproductive neuropeptides and hormones has deepened our understanding of the interaction between bone and the reproductive system. In this review, we provide a contemporary summary of the literature examining the relationship between bone biology and reproductive signals that extend beyond estrogens and androgens, and include kisspeptin, gonadotropin-releasing hormone, follicle-stimulating hormone, luteinizing hormone, prolactin, progesterone, inhibin, activin, and relaxin. A comprehensive and up-to-date review of the recent basic and clinical research advances is essential given the prevalence of clinical reproductive disorders, the emerging roles of upstream reproductive hormones in bone physiology, as well as the urgent need to develop novel safe and effective therapies for bone fragility in a rapidly aging population.
LEFT VENTRICULAR DIASTOLIC DYSFUNCTION ON NON HEMODIALYSIS DAYS IN END STAGE RENAL DISEASE PATIENTS IS ASSOCIATED WITH POOR OUTCOMES
Authors: Muhammad Saad, Shoaib Ashraf, Upreti Prakash, Nikee Shrestha, Sarthak Kulshrestha, Micho Jared, Yue Bing, Haiming Tang, Timothy J. Vittorio, Nisha Ali
Journal: Journal of the American College of Cardiology (2021)
THE ASSOCIATION BETWEEN SEX, RACE, SOCIOECONOMIC STATUS, AND IN-HOSPITAL ALL-CAUSE MORTALITY AMONG PATIENTS ADMITTED FOR HEART FAILURE: A RETROSPECTIVE COHORT STUDY
Authors: Tauben Averbuch, Mohamed Mohamed, Shofiqul Islam, Glen Martin, Lehana Thabane, Mamas Mamas, Harriette G.C. Van Spall
Journal: Journal of the American College of Cardiology (2021)
Late PET/CT Findings of COVID-19 Pneumonia With 2 Different Radiopharmaceuticals in a Patient
Authors: Özlem Şahin, Buğra Kaya, Zeynep Aydın, Mustafa Karaağaç, Gül Kanyılmaz
Journal: Clinical Nuclear Medicine (2021)

We present the 68Ga-PSMA and 18F-FDG PET/CT findings comparatively of a 67-year-old prostate cancer and malignant melanoma patient who had COVID-19 pneumonia 3 months ago. In 68Ga-PSMA PET/CT, ground-glass opacities showing markedly increased PSMA uptake were observed in the patient's lungs. It was learned that the patient had COVID-19 pneumonia 3 months ago and was treated in the intensive care unit for 13 days. In 18F-FDG PET/CT, FDG uptake was minimal in the same areas. In the midterm period after COVID-19 pneumonia, lung PSMA uptake is more intense than FDG, which may help better understand the disease's healing phase.
Neonatal Brain Response to Deviant Auditory Stimuli and Relation to Maternal Trait Anxiety
Authors: Chad M. Sylvester, Michael J. Myers, Michael T. Perino, Sydney Kaplan, Jeanette K. Kenley, Tara A. Smyser, Barbara B. Warner, Deanna M. Barch, Daniel S. Pine, Joan L. Luby, Cynthia E. Rogers, Christopher D. Smyser
Journal: American Journal of Psychiatry (2021)

Objective: Excessive response to unexpected or "deviant" stimuli during infancy and early childhood represents an early risk marker for anxiety disorders. However, research has yet to delineate the specific brain regions underlying the neonatal response to deviant stimuli near birth and the relation to risk for anxiety disorders. The authors used task-based functional MRI (fMRI) to delineate the neonatal response to deviant stimuli and its relationship to maternal trait anxiety. Methods: The authors used fMRI to measure brain activity evoked by deviant auditory stimuli in 45 sleeping neonates (mean age, 27.8 days; 60% female; 64% African American). In 41 of the infants, neural response to deviant stimuli was examined in relation to maternal trait anxiety on the State-Trait Anxiety Inventory, a familial risk factor for offspring anxiety. Results: Neonates manifested a robust and widespread neural response to deviant stimuli that resembles patterns found previously in adults. Higher maternal trait anxiety was related to higher responses within multiple brain regions, including the left and right anterior insula, the ventrolateral prefrontal cortex, and multiple areas within the anterior cingulate cortex. These areas overlap with brain regions previously linked to anxiety disorders and other psychiatric illnesses in adults. Conclusions: The neural architecture sensitive to deviant stimuli robustly functions in newborns. Excessive responsiveness of some circuitry components at birth may signal risk for anxiety and other psychiatric disorders.
PROGNOSTIC IMPACT OF LEFT VENTRICULAR DIASTOLIC FUNCTION E/E’ FOR CARDIOVASCULAR EVENTS IN HOSPITAL PATIENTS COHORT
Authors: Victor Chien-Chia Wu, Yi-Chun Huang, Chun-Li Wang, Ya-Chi Huang, Yu-Sheng Lin, Chang-Fu Kuo, Shao-Wei Chen, Michael Wu, Ming-Shien Wen, Yu-Tung Huang, Shang-hung Chang
Journal: Journal of the American College of Cardiology (2021)
Abstract 13293: Rage Mediates On-Pump-Cabg Induced Lv Stunning
Authors: Markus Velten, Lynette K Rogers, Oliver Dewald, Rainer Meyer, Andreas Hoeft, Daniel Duerr
Journal: Circulation (2019)

Introduction: The mechanism for on-pump Coronary artery bypass grafting (CABG) associated cardiac dysfunctionare complex but may include inflammation due to exposure of the blood to the bypass circ...
Association Between Vaccination With BNT162b2 and Incidence of Symptomatic and Asymptomatic SARS-CoV-2 Infections Among Health Care Workers
Authors: Yoel Angel, Avishay Spitzer, Oryan Henig, Esther Saiag, Eli Sprecher, Hagit Padova, Ronen Ben-Ami
Journal: JAMA (2021)

Randomized clinical trials have provided estimates of the effectiveness of the BNT162b2 vaccine against symptomatic SARS-CoV-2 infection, but its effect on asymptomatic infections remains unclear.To estimate the association of vaccination with the Pfizer-BioNTech BNT162b2 vaccine with symptomatic and asymptomatic SARS-CoV-2 infections among health care workers.This was a single-center, retrospective cohort study conducted at a tertiary medical center in Tel Aviv, Israel. Data were collected on symptomatic and asymptomatic SARS-CoV-2 infections confirmed via polymerase chain reaction (PCR) tests in health care workers undergoing regular screening with nasopharyngeal swabs between December 20, 2020, and February 25, 2021. Logistic regression was used to calculate incidence rate ratios (IRRs) comparing the incidence of infection between fully vaccinated and unvaccinated participants, controlling for demographics and the number of PCR tests performed.Vaccination with the BNT162b2 vaccine vs unvaccinated status was ascertained from the employee health database. Full vaccination was defined as more than 7 days after receipt of the second vaccine dose.The primary outcome was the regression-adjusted IRR for symptomatic and asymptomatic SARS-CoV-2 infection of fully vaccinated vs unvaccinated health care workers. The secondary outcomes included IRRs for partially vaccinated health care workers (days 7-28 after first dose) and for those considered as late fully vaccinated (>21 days after second dose).A total of 6710 health care workers (mean [SD] age, 44.3 [12.5] years; 4465 [66.5%] women) were followed up for a median period of 63 days; 5953 health care workers (88.7%) received at least 1 dose of the BNT162b2 vaccine, 5517 (82.2%) received 2 doses, and 757 (11.3%) were not vaccinated. Vaccination was associated with older age compared with those who were not vaccinated (mean age, 44.8 vs 40.7 years, respectively) and male sex (31.4% vs 17.7%). Symptomatic SARS-CoV-2 infection occurred in 8 fully vaccinated health care workers and 38 unvaccinated health care workers (incidence rate, 4.7 vs 149.8 per 100 000 person-days, respectively, adjusted IRR, 0.03 [95% CI, 0.01-0.06]). Asymptomatic SARS-CoV-2 infection occurred in 19 fully vaccinated health care workers and 17 unvaccinated health care workers (incidence rate, 11.3 vs 67.0 per 100 000 person-days, respectively, adjusted IRR, 0.14 [95% CI, 0.07-0.31]). The results were qualitatively unchanged by the propensity score sensitivity analysis.Among health care workers at a single center in Tel Aviv, Israel, receipt of the BNT162b2 vaccine compared with no vaccine was associated with a significantly lower incidence of symptomatic and asymptomatic SARS-CoV-2 infection more than 7 days after the second dose. Findings are limited by the observational design.
Abstract 15165: Routine Ambulatory Heart Rhythm Monitoring in Patients With Transthyretin Cardiac Amyloidosis
Authors: Zack Dale, Lana Rashdan, Pranav Chandrashekar, Miriam Elman, Stephen B Heitner, Babak Nazer, Ahmad Masri
Journal: Circulation (2020)

Introduction: Atrial fibrillation and flutter (AF/AFL) are common with transthyretin cardiac amyloidosis (ATTR-CM). These patients have higher risk for thromboembolism. Detection of AF/AFL may thus be especially important, but the role of routine ambulatory monitoring in asymptomatic patients is unclear. Methods: A single center observational study of patients seen at our Amyloidosis Center with wild-type or hereditary ATTR-CM diagnosed between 2005-2019. Records were reviewed to see if AF/AFL was present at baseline. In those without known AF/AFL, ambulatory monitor (duration 2-30 days) was done every 6 months when feasible as part of our routine practice. Patients with cardiovascular implantable electronic devices (CIED) instead had routine device interrogations. Results: Ninety-four patients with ATTR-CM (mean age 71.4±11.4 years, 88.3% male) had mean follow-up 2.2±1.9 years (200 patient-years). AF/AFL was seen in 62 patients (66.0%): 35 (56.5%) by symptoms, 18 (29.0%) incidentally by monitor or CIED, and 9 in whom method of AF/AFL diagnosis was unknown. Forty-one patients (66.1%) had AF/AFL before ATTR-CM diagnosis by of median 26.3 (IQR 4.3-40.9) months. New AF/AFL was diagnosed in 21/53 remaining patients with known ATTR-CM - 11 (52.4%) were incidentally diagnosed (Figure 1). Median time between ATTR-CM and AF/AFL diagnoses was 10.3 (IQR 7.0-25.8) months and 5.9 (IQR 2.2-22.3) months in symptomatic versus incidentally diagnosed patients (Mann-Whitney U=35, p=0.14). Anticoagulation (AC) was started in 9/11 (81.8%) due to incidental AF/AFL. One patient had AC for prior DVT; the other had no AC per patient preference. No strokes occurred in patients on AC. Conclusions: We found a high rate of incidentally diagnosed AF/AFL in patients with ATTR-CM. Detection of AF/AFL led to change in therapy. This finding affirms a need for routine ambulatory monitoring in asymptomatic patients with ATTR-CM. Optimal duration of monitoring needs further investigation.
LONGITUDINAL ASSOCIATIONS OF FAT MASS, LEAN MASS, BODY MASS INDEX AND BLOOD PRESSURE FROM CHILDHOOD THROUGH YOUNG ADULTHOOD WITH CAROTID-FEMORAL PULSE WAVE VELOCITY AND CAROTID INTIMA-MEDIA THICKNESS AT AGE 24.5 YEARS
Authors: Andrew O. Agbaje, Alan R. Barker, Tomi-Pekka Tuomainen
Journal: Journal of the American College of Cardiology (2021)
THE CARDIONERDS CASE REPORT SERIES: CONNECTING THE CARDIOLOGY COMMUNITY DURING THE COVID-19 PANDEMIC
Authors: Karan Desai, Daniel Ambinder, Nosheen Reza, Eunice Dugan, Evelyn Song, Colin Blumenthal, Thomas Das, Richard Ferraro, Bibin Varghese, Amit Goyal
Journal: Journal of the American College of Cardiology (2021)
Screening for Hypertension in Adults
Authors: Alex H. Krist, Karina W. Davidson, Carol M. Mangione, Michael Cabana, Aaron B. Caughey, Esa M. Davis, Katrina E. Donahue, Chyke A. Doubeni, Martha Kubik, Li Li, Gbenga Ogedegbe, Lori Pbert, Michael Silverstein, James Stevermer, Chien-Wen Tseng, John B. Wong
Journal: JAMA (2021)

<h3>Importance</h3> Hypertension is a prevalent condition that affects approximately 45% of the adult US population and is the most commonly diagnosed condition at outpatient office visits. Hypertension is a major contributing risk factor for heart failure, myocardial infarction, stroke, and chronic kidney disease. <h3>Objective</h3> To reaffirm its 2015 recommendation, the US Preventive Services Task Force (USPSTF) commissioned a systematic review to evaluate the benefits and harms of screening for hypertension in adults, the accuracy of office blood pressure measurement for initial screening, and the accuracy of various confirmatory blood pressure measurement methods. <h3>Population</h3> Adults 18 years or older without known hypertension. <h3>Evidence Assessment</h3> Using a reaffirmation deliberation process, the USPSTF concludes with high certainty that screening for hypertension in adults has substantial net benefit. <h3>Recommendation</h3> The USPSTF recommends screening for hypertension in adults 18 years or older with office blood pressure measurement. The USPSTF recommends obtaining blood pressure measurements outside of the clinical setting for diagnostic confirmation before starting treatment. (A recommendation)
MEMBRANOUS SEPTUM LENGTH PREDICTS NEW CONDUCTION ABNORMALITIES AFTER SURGICAL AORTIC VALVE REPLACEMENT
Authors: Makoto Nakashima, Hasan Jilaihawi, Yuxin He, David Williams, Michael Querijero, Illya Pushkar, Mathew Williams, Kazuhiro Hisamoto
Journal: Journal of the American College of Cardiology (2021)
A Commentary on “COVID-19 impact on Surgical Training and Recovery Planning (COVID-STAR) - A cross-sectional observational study”
Authors: Andrés Mauricio Ojeda-Gutiérrez, María Bernarda Quiroz-Martínez, Michael Gregorio Ortega-Sierra, Luis Francisco Mendoza-Castillo, Ivan David Lozada-Martínez
Journal: International Journal of Surgery (2021)
CONTEMPORARY UTILIZATION OF A CHEST PAIN UNIT IN A LARGE TERTIARY CARE REFERRAL CENTER COMPARED TO STANDARD CARE APPROACH: LESSONS LEARNED FROM A REAL WORLD COMMUNITY PRACTICE
Authors: Blair L. Tilkens, Rafath Ullah, Stevie Steiro, Ana Cristina Perez Moreno, Nicholas Sommers, Nataly Stenzel, Joell Salfer, Adil Wani, Babak Haddadian, Suhail Allaqaband, Tanvir Bajwa, M. Fuad Jan
Journal: Journal of the American College of Cardiology (2021)
An adaptive, biomarker-directed platform study of durvalumab in combination with targeted therapies in advanced urothelial cancer
Authors: Thomas Powles, Danielle Carroll, Simon Chowdhury, Gwenaelle Gravis, Florence Joly, Joan Carles, Aude Fléchon, Pablo Maroto, Daniel Petrylak, Frédéric Rolland, Natalie Cook, Arjun V. Balar, Srikala S. Sridhar, Matthew D. Galsky, Petros Grivas, Alain Ravaud, Robert Jones, Jan Cosaert, Darren Hodgson, Iwanka Kozarewa, Richard Mather, Robert McEwen, Florence Mercier, Dónal Landers
Journal: Nature Medicine (2021)