tbuckley/cabot-search huggingface dataset:
Outcome and assessment after the modified Fontan procedure for hypoplastic left heart syndrome.
Authors: P EFarrell, A CChang, K AMurdison, J MBaffa, W INorwood, J DMurphy
Journal: Circulation (1992)

BACKGROUNDWe reviewed the outcome of 76 consecutive patients (age range, 5 months to 6 years; median age, 19 months) who underwent a modified Fontan procedure after initial palliative surgery for hypoplastic left heart syndrome (HLHS) between January 1984 and December 1989.METHODS AND RESULTSModifications of the Fontan procedure included transatrial baffle of pulmonary venous return to the tricuspid valve (n = 10) or inferior vena cava baffle within the right atrium to the superior vena caval-pulmonary artery anastomosis, with pulmonary artery augmentation (n = 66). Actuarial survival rates were 74% (1 month), 58% (12 months), 56% (2 years), and 52% (4 years). Of the 43 survivors, 25 patients have returned for postoperative cardiac catheterization at a medium of 13 months after the Fontan procedure. Mean +/- SD hemodynamic values were cardiac index, 2.8 +/- 0.6 l/min/m2; right arterial pressure, 11 +/- 2 mm Hg; pulmonary artery wedge pressure, 6 +/- 3 mm Hg; and arterial oxygen saturation, 94 +/- 3%. No p...
Symptoms and Functional Impairment Assessed 8 Months After Mild COVID-19 Among Health Care Workers
Authors: Sebastian Havervall, Axel Rosell, Mia Phillipson, Sara M. Mangsbo, Peter Nilsson, Sophia Hober, Charlotte Thålin
Journal: JAMA (2021)

This cohort study describes COVID-19–related symptoms persisting 8 months after SARS-CoV-2 infection among Swedish health care workers and self-reported effects of the residual symptoms on respondents' home, work, and social function.
Endoscopic Submucosal Dissection (ESD) Of A Neuroendocrine Tumor Of The Duodenal Bulb Using Dual-Knife-J And Traction With Rubberband/Clip Technique
Authors: T Beyna
Journal: Endoscopy (2021)

Neuroendocrine tumors of the duodenum are often well differentialted and associated with a low risk of local lymph node metastases. Therefore, endoscopic resection (ER) has evolved as a less invasive alternative to surgery.
Effect of transcutaneous electrical nerve stimulation on coronary blood flow.
Authors: AChauhan, P AMullins, S IThuraisingham, GTaylor, M CPetch, P MSchofield
Journal: Circulation (1994)

BACKGROUNDAlthough neurostimulation has been shown to be of benefit in angina pectoris, the exact mechanism of its action is not clear. This study was performed to examine the effect of transcutaneous electrical nerve stimulation on coronary blood flow.METHODS AND RESULTSThe effect of transcutaneous electrical nerve stimulation was studied in 34 syndrome X patients (group 1), 15 coronary artery disease patients (group 2), and 16 heart transplant patients (group 3). Coronary blood flow velocity (CBFV) in the left coronary system was measured at rest and after a 5-minute stimulation period with a Judkins Doppler. There was a significant increase in the resting CBFV in group 1 (from 6.8 +/- 4.1 to 10.5 +/- 5.7 cm/s, P < .001) and group 2 (from 6.8 +/- 4.1 to 10.5 +/- 5.7 cm/s, P < .001). However, there was no significant change in the resting CBFV in group 3. There were no significant changes in the coronary arterial diameters as a result of neurostimulation. There was a significant decrease in the epinephri...
Effects of pHi on isometric force and [Ca2+]i in porcine coronary artery smooth muscle.
Authors: RNagesetty, R JPaul
Journal: Circulation Research (1994)

During ischemia or hypoxia, alterations in pHi may play a significant role in alteration of vessel wall function. We studied the effects of altering pHi on isometric force and [Ca2+]i in porcine coronary artery. pHi was altered at constant pHo by use of NH4Cl and measured with the fluorescent dye BCECF. [Ca2+]i was monitored with fura 2 and ratiometric fluorescence measurements. Addition of NH4Cl elicited a concentration-dependent (2 to 30 mmol/L) sustained increase in isometric force in unstimulated tissues. In tissues stimulated with KCl (29 mmol/L) or U46619 (1 mumol/L), addition of NH4Cl elicited a rapid but transient decrease followed by a sustained increase in force above the initial stimulated levels. Removal of NH4Cl was associated with a transient decrease and increase followed by a prolonged depression of force and slow recovery to initial levels. Addition of NH4Cl elicited a rapid monotonic increase in pHi and then a slow recovery toward initial levels; washout of NH4Cl led to a rapid acidifica...
Neural regulation of renin release: experimental evidence and clinical implications in arterial hypertension.
Authors: A SZanchetti
Journal: Circulation (1977)

The assessment of the possible role played by the renin-angiotensin system in maintaining arterial hypertension requires an understanding of the mechanisms regulating renin release from the kidney. In addition to intrarenal mechanisms of control, recent investigation stresses the importance of sympathetic influences on the juxtaglomerular cells both in experimental animals and in man. Studies with beta-adrenergic blocking agents, interfering with sympathetic release of renin, and with peptides interfering with sympathetic release of renin, and with peptides interfering with the generation or action of angiotensin II, suggest that renin may play some pressor role in a number of cases of hypertension: a major one in the small group of patients with high plasma renin, and possibly a minor one in the large population of patients whose renin is stimulated by treatment with diuretics and vasodilators. On the whole, available evidence suggests that renin disturbances in essential hypertension are rarely primary....
Ryanodine does not affect calcium current in guinea pig ventricular myocytes in which Ca2+ is buffered.
Authors: C WBalke, W GWier
Journal: Circulation Research (1991)

Calcium current in mammalian ventricular muscle is altered in the presence of ryanodine. Previous studies performed on rat ventricular cells have shown a slowing of Ca2+ current inactivation and suggest the hypothesis that ryanodine, by reducing the release of Ca2+ from the sarcoplasmic reticulum, reduces the availability of Ca2+ for inactivation of Ca2+ current (Ca(2+)-dependent inactivation). Another hypothesis is that the effects of ryanodine on Ca2+ current are due to a mechanical connection of the ryanodine receptor with the L-type Ca2+ channel. To further test these hypotheses we examined the effect of ryanodine on Ca2+ current in single voltage-clamped guinea pig ventricular myocytes that contained Ca2+ indicator and Ca2+ buffer. We used fura 2 (pentapotassium salt) to confirm that the ryanodine we used was capable of abolishing Ca2+ release from the sarcoplasmic reticulum during the period in which it was present. We perfused the cells with 10 mM EGTA to block changes in intracellular Ca2+ concent...
Increased venous pressure causes myogenic constriction of cerebral arterioles during local hyperoxia.
Authors: E PWei, H AKontos
Journal: Circulation Research (1984)

The responses of cerebral (pial) arterioles to increased venous pressure were examined in anesthetized cats equipped with cranial windows for the observation of the cerebral microcirculation. Increased venous pressure was induced by occlusion of the superior vena cava. Intracranial pressure was kept constant. Increased venous pressure when the window was filled with stationary cerebrospinal fluid caused 9-12% arteriolar dilation. Cerebral arteriolar dilation of equal magnitude (8-12%) was also seen when the space under the cranial window was perfused with fluorocarbon FC-80 equilibrated with 100% nitrogen. Increased venous pressure when the cranial window space was perfused with fluorocarbon equilibrated with 100% oxygen caused a small (5%) but significant arteriolar constriction. These results show that the dominant mechanism of autoregulation in the cerebral arterioles is metabolic, and that it involves an oxygen-sensitive mechanism. Myogenic vasoconstriction is unmasked during venous hypertension when ...
George E. Brown memorial lecture. Role of atrial peptides in body fluid homeostasis.
Authors: B JBallermann, B MBrenner
Journal: Circulation Research (1986)

Extracts of mammalian atria, but not ventricles, induce marked diuresis, natriuresis, and reduction in blood pressure when infused systemically in rats and dogs. These extracts also inhibit aldosterone biosynthesis and renal renin release. Natriuretic peptides, 21 amino acids and longer, have been isolated from atria of rodents and man, and share a nearly homologous amino acid sequence at the carboxyterminus. Natriuretic activity resides in a 17-amino acid ring formed by a disulfide bridge, and the C-terminal Phe-Arg appears necessary for full biological potency. The deoxyribonucleic acid-encoding atrial natriuretic peptides have been cloned and the gene structure elucidated. Reduction of the diuretic and natriuretic responses to an acute volume load by right atrial appendectomy first suggested a role for atrial peptides in the physiological response to plasma volume expansion. Subsequently, release of peptides with natriuretic and spasmolytic properties from isolated heart preparations in response to rig...
Co-expression of ErbB family members in human breast cancer: Her-2/neu is the preferred dimerization candidate in nodal-positive tumors
Authors: C. F. Singer, G. Hudelist, M. Manavi, K. Pischinger, E. Kubista, K. Czerwenka
Journal: Journal of Clinical Oncology (2004)

9522 Background: Overexpression of members of the ErbB receptor family has been asssociated with malignant transformation and the amplification of Her-2/neu in tumor tissue is now an established prognostic factor in breast cancer. In order to initiate signal transduction, ErbB receptor monomers need to form homo- or hetero- dimers. The composition of these dimers is thought to greatly influence both quality and quantity of downstream signalling pathways, and to ultimately determine the elicited biological response. Methods: The protein expression pattern of all four ErbB receptors EGF-R, Her-2/neu, Her-3 and Her-4, and expression of their putative ligands EGF, TGF-α and HRG was investigated in 74 women with invasive breast cancer by membrane isolation and Western blot analysis. Results: The co-expression of all four ErbB family members was detected in 79,7% of cases, and of all of the three investigated ligands in 82,4%. While we did not observe a correlation between EGFR and Her-2/neu or Her-4 protein expression, EGFR and Her-3 (p=0.005), and Her-3 and Her-4 (p=0.05) were clearly co-expressed. The strongest overall correlation, however, was found between Her-2/neu and Her-3 (p=0.001) and between Her-2/neu and Her-4 (p=0.001). This was particularly true in nodal-positive tumors (p<0.001 and p=0.002, respectively) whereas in nodal-negative tumors the co-expression was either less significant (Her-2/neu and Her-3: p=0.01) or not significant at all (Her-2/neu and Her-4). The co-expression of EGFR/Her-3 was associated with the expression of all three ligands, whereas the Her-2/neu/Her-3 was correlated with HRG (p=0.002), thereby indicating a functional relation between specific receptor-dimer combinations and putative ligands. Conclusion: Taken together, we have performed a comprehensive survey of ErbB system expression in breast cancer, and have demonstrated the presence of a co-regulated receptor/ligand system in vivo. Her-2/neu appears to function as the preferred co-expression partner in nodal-positive tumors, thus rendering him the most likely dimerization candidate in malignant breast tumors. No significant financial relationships to disclose.
Impact Of The Covid 19 Pandemy On The Emergency Endoscopic Activity
Authors: M Nasiri, O El Mqaddem, A Taiymi, A Zazour, A El Mekkaoui, W Khannoussi, G Kharrasse, Z Ismaili
Journal: Endoscopy (2021)

Methods The is a retrospective,descriptive and comparative study of epidemiological, clinical and endoscopic characteristics of patients who had emergency ERCP over two successive 8 months:Period(1):01/03/2019-31/10/2019 and Period(2):01/03/2020-31/10/2020 in our department of hepatogastroenterology of university hospital Mohammed VI Oujda.
HBV/Pregenomic RNA Increases the Stemness and Promotes the Development of HBV‐Related HCC Through Reciprocal Regulation With Insulin‐Like Growth Factor 2 mRNA‐Binding Protein 3
Authors: Wen‐bin Ding, Meng‐chao Wang, Jian Yu, Gang Huang, Da‐peng Sun, Lei Liu, Jia‐ning Zhang, Yuan Yang, Hui Liu, Wei‐ping Zhou, Fu Yang, Sheng‐xian Yuan
Journal: Hepatology (2021)

Background and Aims HBV‐pgRNA (pregenomic RNA) has been proposed for predicting the response of nucleos(t)ide analogue (NA) treatment, guiding discontinuation of NA therapy and monitoring the emergence of viral mutations. However, the contributions of HBV‐pgRNA to HCC remain open for study. Approach and Results Double‐center cohorts of serum samples with undetectable serum HBV‐DNA (below the lower limit of detection) were obtained from long‐term NA‐treated (≥48 weeks) HBV‐related HCC patients. The correlation between serum pgRNA concentration and the prognosis of HCC were analyzed. The role pgRNA played in HCC development was assessed both in vitro and in vivo . Our findings revealed that for patients who underwent long‐term NA therapy with undetectable serum HBV‐DNA, patients with high serum pgRNA expression had a poorer overall survival rate and higher cumulative recurrence rate after hepatectomy. Experiments demonstrated that pgRNA promotes proliferation, stemness, and tumorigenicity of HCC cells. Mechanistically, we found that pgRNA could up‐regulate the expression of insulin‐like growth factor 2 mRNA‐binding protein 3 (IGF2BP3), a well‐proven oncoprotein, at the posttranscriptional level. Furthermore, interferon (IFN)‐α‐2a could degrade the stability of pgRNA through increasing its N6‐methyladenosine (m6A) RNA modification. Collectively, our findings uncover that serum pgRNA could serve as a potential biomarker for predicting the prognosis and recurrence of HCC in patients who received long‐term NA therapy with undetectable serum HBV‐DNA; and the pgRNA‐IGF2BP3 axis plays an important role in the development of HBV‐related HCC. Moreover, IFN‐α‐2a could reduce the stability of pgRNA by increasing its m6A RNA modification level, thereby suppressing the development of HBV‐related HCC. Conclusions In conclusion, our studies reveal a significance and mechanism of HBV‐pgRNA in increasing stemness features and offer a potential prognostic marker and a therapeutic target for HBV‐related HCC.
Re: Final Results of an EORTC-GU Cancers Group Randomized Study of Maintenance Bacillus Calmette-Guérin in Intermediate- and High-risk Ta, T1 Papillary Carcinoma of the Urinary Bladder: One-third Dose Versus Full Dose and 1 Year Versus 3 Years of Maintenance
Authors: Brant A Inman
Journal: European Urology (2013)
Selective inhibition of the contractile apparatus. A new approach to modification of infarct size, infarct composition, and infarct geometry during coronary artery occlusion and reperfusion.
Authors: DGarcia-Dorado, PThéroux, J MDuran, JSolares, JAlonso, ESanz, RMunoz, JElizaga, JBotas, FFernandez-Avilés
Journal: Circulation (1992)

BACKGROUNDMyocardial reperfusion is associated with calcium overload and cell contracture, mechanisms that may precipitate cell death. In this study, we tested the hypothesis that in vivo inhibition of this contracture could lead to cell preservation in an open-chest large animal model.METHODS AND RESULTSRegional myocardium function was measured during a selective intracoronary infusion of 2,3-butanedione monoxime (BDM), a specific inhibitor of actin-myosin coupling, in the control state (10 pigs) and in a protocol of a 51-minute coronary occlusion followed by reperfusion (40 pigs). The effects on coronary artery blood flow in the basal state were also studied (seven pigs). Intramyocardial distribution of the infusate during coronary occlusion, myocardial water content after 30 minutes of reperfusion and area at risk, infarct size, type of histological necrosis, and infarct geometry after 24 hours of reperfusion were assessed. Methods used included electromagnetic flowmeter, radiolabeled microspheres, sub...
Assessment of Pediatric Admissions for Kawasaki Disease or Infectious Disease During the COVID-19 State of Emergency in Japan
Authors: Takuya Hara, Kenji Furuno, Kenichiro Yamamura, Junji Kishimoto, Yumi Mizuno, Kenji Murata, Sagano Onoyama, Ken Hatae, Megumi Takemoto, Yoshito Ishizaki, Shunsuke Kanno, Kazuo Sato, Yoshitomo Motomura, Yasunari Sakai, Shouichi Ohga, Mayumi Yashiro, Yoshikazu Nakamura, Toshiro Hara
Journal: JAMA Network Open (2021)

The development of Kawasaki disease (KD) has been suggested to be associated with droplet- or contact-transmitted infection; however, its triggers and transmission modes remain to be determined. Under an epidemic of SARS-CoV-2, the COVID-19 state of emergency in Japan served as a nationwide social experiment to investigate the impact of quarantine or isolation on the incidence of KD.To assess the role of droplet or contact transmission in the etiopathogenesis of KD.This multicenter, longitudinal, cross-sectional study was conducted from 2015 to 2020 at Fukuoka Children's Hospital and 5 adjacent general hospitals. The number of admissions for KD and infectious diseases were analyzed. Participants were pediatric patients admitted to the participating hospitals for KD or infectious diseases.Quarantine and isolation owing to the COVID-19 state of emergency.The primary end points were the ratios of patients with KD to patients with respiratory tract or gastrointestinal infections admitted from April to May in 2015 to 2019 and 2020. A Poisson regression model was used to analyze them.The study participants included 1649 patients with KD (median [interquartile range] age, 25 [13-43] months; 901 boys [54.6%]) and 15 586 patients with infectious disease (data on age and sex were not available for these patients). The number of admissions for KD showed no significant change between April and May in 2015 to 2019 vs the same months in 2020 (mean [SD], 24.8 [5.6] vs 18.0 [4.0] admissions per month; 27.4% decrease; adjusted incidence rate ratio [aIRR], 0.73; 95% CI, 0.48-1.10; P = .12). However, the number of admissions for droplet-transmitted or contact-transmitted respiratory tract infections (mean [SD], 157.6 [14.4] vs 39.0 [15.0] admissions per month; 75.3% decrease; aIRR, 0.25; 95% CI, 0.17-0.35; P < .001) and gastrointestinal infections (mean [SD], 43.8 [12.9] vs 6.0 [2.0] admissions per month; 86.3% decrease; aIRR, 0.14; 95% CI, 0.04-0.43; P < .001) showed significant decreases between April and May in 2015 to 2019 vs the same months in 2020 (total, 12 254 infections). Thus, the ratio of KD to droplet- or contact-transmitted respiratory tract and gastrointestinal infections incidence in April and May 2020 was significantly increased (ratio, 0.40 vs 0.12; χ21 = 22.76; P < .001).In this study, the significantly increased incidence of KD compared with respiratory tract and gastrointestinal infections during the COVID-19 state of emergency suggests that contact or droplet transmission is not a major route for KD development and that KD may be associated with airborne infections in most cases.
Continuing evolution of therapy for coronary artery disease. Initial results from the era of coronary angioplasty.
Authors: D BMark, C LNelson, R MCaliff, F EHarrell, K LLee, R HJones, D FFortin, R SStack, D DGlower, L RSmith
Journal: Circulation (1994)

BACKGROUNDSurvival after coronary artery bypass graft surgery (CABG) and medical therapy in patients with coronary artery disease (CAD) has been studied in both randomized trials and observational treatment comparisons. Over the past decade, the use of coronary angioplasty (PTCA) has increased dramatically, without guidance from either randomized trials or prospective observational comparisons. The purpose of this study was to describe the survival experience of a large prospective cohort of CAD patients treated with medicine, PTCA, or CABG.METHODS AND RESULTSThe study was designed as a prospective nonrandomized treatment comparison in the setting of an academic medical center (tertiary care). Subjects were 9263 patients with symptomatic CAD referred for cardiac catheterization (1984 through 1990). Patients with prior PTCA or CABG, valvular or congenital disease, nonischemic cardiomyopathy, or significant (> or = 75%) left main disease were excluded. Baseline clinical, laboratory, and catheterization data...
A structure-supporting, self-healing, and high permeating hydrogel bioink for establishment of diverse homogeneous tissue-like constructs
Authors: Hongqing Chen, Fei Fei, Xinda Li, Zhenguo Nie, Dezhi Zhou, Libiao Liu, Jing Zhang, Haitao Zhang, Zhou Fei, Tao Xu
Journal: Bioactive Materials (2021)

The ready-to-use, structure-supporting hydrogel bioink can shorten the time for ink preparation, ensure cell dispersion, and maintain the preset shape/microstructure without additional assistance during printing. Meanwhile, ink with high permeability might facilitate uniform cell growth in biological constructs, which is beneficial to homogeneous tissue repair. Unfortunately, current bioinks are hard to meet these requirements simultaneously in a simple way. Here, based on the fast dynamic crosslinking of aldehyde hyaluronic acid (AHA)/N-carboxymethyl chitosan (CMC) and the slow stable crosslinking of gelatin (GEL)/4-arm poly(ethylene glycol) succinimidyl glutarate (PEG-SG), we present a time-sharing structure-supporting (TSHSP) hydrogel bioink with high permeability, containing 1% AHA, 0.75% CMC, 1% GEL and 0.5% PEG-SG. The TSHSP hydrogel can facilitate printing with proper viscoelastic property and self-healing behavior. By crosslinking with 4% PEG-SG for only 3 min, the integrity of the cell-laden construct can last for 21 days due to the stable internal and external GEL/PEG-SG networks, and cells manifested long-term viability and spreading morphology. Nerve-like, muscle-like, and cartilage-like
Abstract 15030: Background and Complications in Patients With Takotsubo Cardiomyopathy (Insights From the National Inpatient Sample)
Authors: Alberto Batarseh, Talal Alzahrani, Joseph Krepp
Journal: Circulation (2019)

Introduction: Takotsubo cardiomyopathy (TTC) is an acute and typically reversible heart failure syndrome following either a physiologic or emotional stressor with the classic echocardiographic find...
Beyond Decriminalization: Ending the War on Drugs Requires Recasting Police Discretion through the Lens of a Public Health Ethic
Authors: Brandon del Pozo, Leo Beletsky, Jeremiah Goulka, John Kleinig
Journal: The American Journal of Bioethics (2021)

Earp, Lewis, and Hart (2021) argue the pursuit of racial justice requires a summary end to the war on drugs. In surveying the racially disparate harms of an enforcement-oriented, punitive, and ulti...
Abortion (Amendment) Bill
Authors: J. O'Melia
Journal: BMJ (1980)

Abortion (Amendment) Bill H C McLaren, frcog; J O'Melia, mrcpsych; A Pattison, frcs; D A Roche, mb; R McGlone; MBH Wilson, mb; R E J Ryder, mb; Anne M Bancewicz, mb; Elizabeth M Elliott, mb; D B Paintin, frcog; J C Miller, frcog; J Ashton, mrcpsych. 477 Legal abortion in England and Wales 1968-78 M J McCarthy, mfcm. 479 Improvements in obstetric anaesthetic services B M Hibbard, frcog, and others. 480 Treatment of infertility with levodopa F Lechin, md, and Bertha van der Dijs, md 480 Debendox and the media R Harris, frcp, and Dian Donnai, mrcp; R P Balfour, mrcog. 480 What the fetus feels A R Dewsbury, mrcgp. 481 Dislocated and dislocatable hip in the newborn D M Dunn, frcs, and S M O'Riordan, frcs. 481 Infant feeding in Chinese populations Fiona House, srd, and K M Goel, frcp. .. 481 Postoperative pain F H Creed, mrcpsych. 481 Guidelines to aid ethical committees considering research in children J J Corkery, frcs. 481 Depot medroxyprogesterone and vaginal bleeding in the puerperium M Thiery, phd, and others. 481 Cutaneous manifestations of hydrallazine toxicity A P Brooks, md, and J W Paulley, frcp ; R G Petty, MB, and D R K Medley, frcp_ 482 Phenobarbitone and epilepsy A Richens, mrcp, and J R Oxley, mrcp.482 Epileptic drugs and the police O M Jones. 483 Diabetic impotence J H J Bancroft, frcpsych, and F C-W Wu, mrcp . 483