tbuckley/cabot-search huggingface dataset:
TRANSCATHETER AORTIC VALVE REPLACEMENT IN PATIENTS WITH AORTIC STENOSIS AND CARDIAC AMYLOIDOSIS: AN ASSESSMENT OF PRACTICE PATTERNS
Authors: Tasveer Khawaja, Shilpkumar Arora, Rahul Jaswaney, Akhil Jain, Nirav Arora, Sidakpal Panaich, Steven James Filby, Guilherme Attizzani
Journal: Journal of the American College of Cardiology (2022)
Shared signatures and divergence in skin microbiomes of children with atopic dermatitis and their caregivers
Authors: Minghao Chia, Ahmad N.M. Naim, Angeline S.L. Tay, Karmun Lim, Kean Lee Chew, See Jie Yow, John Chen, John E.A. Common, Niranjan Nagarajan, Elizabeth Huiwen Tham
Journal: Journal of Allergy and Clinical Immunology (2022)
Abstract P2-12-06: Pathological response-guided postoperative treatment strategy for positive HR/negative HER2 and positive lymphnodes breast cancer patients with non-responsive pathological results to neoadjuvant chemotherapy
Authors: Yang Yang, Xue Chen, Zhaoqing Fan, Yingjian He, Yuntao Xie, Jinfeng Li, Tianfeng Wang, Tao Ouyang
Journal: Cancer Research (2022)

Abstract Objective: No consensus up to date suggesting whether patients with positive HR/negative HER-2 and positive lymph nodes breast cancer should receive additional adjuvant chemotherapy following a poor response to neoadjuvant chemotherapy to acquire a better DDFS. The main aim of this trial is to compare the 5-year DDFS between additional adjuvant chemotherapy plus endocrine therapy group and endocrine alone group following 4 cycles neoadjuvant chemotherapy. Method: A multicenter, open-label, randomized, controlled, phase 3 trial was conducted. All patients enrolled in the study were HR+ HER2- LN+ breast cancer patients completing four cycles neoadjuvant chemotherapy, with a non-responsive pathological result to neoadjuvant chemotherapy. The non-responsive criterion was defined as Miller and Payne staging grade1 to grade 3, or any grade of Miller and Payne staging but residual positive lymph nodes were found in surgical specimen. All enrolled patients were randomly assigned to receive four cycles non-cross resistant regimen plus endocrine therapy, or endocrine therapy alone. The primary endpoint was DDFS, and the secondary endpoint was iDFS and OS. Result: From October 2010 to September 2018, a total of 391 patients were enrolled for eligibility. The final ITT analysis compromised 379 patients (187 in adjuvant chemotherapy plus endocrine therapy group, and 192 in endocrine therapy alone group). After a median follow-up of 72.4 months, the 5-year distant disease free survival estimate was 92% (95% CI 88-96) in the adjuvant chemotherapy group and 90% (86-94) in the endocrine therapy alone group (HR 0.79, 95% CI 0.45-1.37) (P=0.401). In the prespecified CEF subgroup, the 5-year DDFS was 94% (95% CI 90-98) in adjuvant chemotherapy group, and 91% (95% CI 87-94) in endocrine group (HR 0.68, 95% CI 0.36-1.30) (P=0.249). In the exploratory analysis, we found a better 5-year DDFS trend in adjuvant chemotherapy group in ypN+ patients in CEF subgroup (P=0.196). Conclusion: A better 5-year DDFS trend in additional adjuvant chemotherapy plus endocrine therapy can be found for patients with positive HR/negative HER-2 and positive lymph nodes following a poor response to neoadjuvant chemotherapy. Citation Format: Yang Yang, Xue Chen, Zhaoqing Fan, Yingjian He, Yuntao Xie, Jinfeng Li, Tianfeng Wang, Tao Ouyang. Pathological response-guided postoperative treatment strategy for positive HR/negative HER2 and positive lymphnodes breast cancer patients with non-responsive pathological results to neoadjuvant chemotherapy [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P2-12-06.
IMPROVED MORTALITY RISK ASSESSMENT FROM MYOCARDIAL PET FLOW, PERFUSION AND CALCIUM SCORES USING ARTIFICIAL INTELLIGENCE
Authors: Ananya Singh, Konrad Pieszko, Aakash Shanbhag, Jacek Kwiecinski, Robert JH Miller, Yuka Otaki, Aditya Killekar, Paul Kavanagh, Serge Van Kriekinge, Chih-Chun Wei, Tejas Parekh, Daniel S. Berman, Piotr Slomka
Journal: Journal of the American College of Cardiology (2022)
A Different Case of Penumbra—Reply
Authors: Kushal T. Kadakia, Joseph S. Ross, Harlan M. Krumholz
Journal: JAMA Internal Medicine (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Development of Open-Angle Glaucoma in Adults With Seropositive Rheumatoid Arthritis in Korea
Authors: Seung Hoon Kim, Sung Hoon Jeong, Hyunkyu Kim, Eun-Cheol Park, Suk-Yong Jang
Journal: JAMA Network Open (2022)

<h3>Importance</h3> Although evidence is emerging that autoimmunity may be associated with neurodegeneration in glaucoma (beyond intraocular pressure-mediated damage), there is limited evidence connecting rheumatoid arthritis (RA), the most common autoimmune disease, with the risk of developing primary open-angle glaucoma (POAG). <h3>Objective</h3> To investigate whether RA is associated with increased risk of POAG among Korean older adults. <h3>Design, Setting, and Participants</h3> A nationwide propensity-matched cohort study was conducted using data from the Korean National Health Insurance Service-Senior cohort from 2002 to 2013. Data analysis was performed from November 2020 to July 2021. <h3>Exposures</h3> New onset RA. <h3>Main Outcomes and Measures</h3> The main outcome was development of POAG. The Kaplan-Meier method was used to calculate the cumulative incidence of POAG, and the incidence rate of POAG was estimated using a Poisson regression. A Cox proportional hazards regression model was used to investigate associations between RA and risk of POAG. <h3>Results</h3> Among 10 245 participants, 7490 (73.1%) were women, and the mean (SD) age was 67.70 (4.84) years. A total of 2049 patients with incident seropositive RA and 8196 time-dependent, propensity score–matched, risk-set controls were included. POAG developed in 86 of 2049 patients with RA and 254 of 8196 matched controls. The cumulative incidence of POAG was higher in the RA cohort than in the matched controls. In the RA cohort, the incidence rate of POAG was 981.8 cases per 100 000 person years (95% CI, 794.3-1213.7 cases per 100 000 person years), whereas in the matched controls, the incidence rate was 679.5 cases per 100 000 person years (95% CI, 600.8-768.3 cases per 100 000 person years). Patients with RA were more likely to develop POAG than the matched controls (hazard ratio [HR], 1.44; 95% CI, 1.13-1.84). Increased POAG risk in the RA cohort was predominantly observed 2 years into the follow-up period (HR, 1.83; 95% CI, 1.28-2.61) and in those aged 75 years or older (HR, 2.12; 95% CI, 1.34-3.35). <h3>Conclusions and Relevance</h3> These findings suggest that RA is associated with a higher risk of developing POAG, especially within 2 years after diagnosis or among patients aged 75 years or older. There may be a common pathophysiological pathway between RA and POAG that is possibly immune mediated, and the nature of this association warrants further investigation.
PROGNOSTIC SIGNIFICANCE OF LIVER STIFFNESS ASSESSED BY MAGNETIC RESONANCE ELASTOGRAPHY IN PATIENTS WITH HEART FAILURE
Authors: Atsushi Tada, Toshiyuki Nagai, Yoshiya Kato, Kazunori Omote, Yuki Takahashi, Kohei Saiin, Seiichiro Naito, Sakae Takenaka, Yoshifumi Mizuguchi, Yuta Kobayashi, Takao Konishi, Takuma Sato, Kiwamu Kamiya, Toshihisa Anzai
Journal: Journal of the American College of Cardiology (2022)
Long‐term eltrombopag for bone marrow failure depletes iron
Authors: David J. Young, Xing Fan, Emma M. Groarke, Bhavisha Patel, Ronan Desmond, Thomas Winkler, Andre Larochelle, Katherine R. Calvo, Neal S. Young, Cynthia E. Dunbar
Journal: American Journal of Hematology (2022)

Eltrombopag (EPAG) has been approved for the treatment of aplastic anemia and for immune thrombocytopenia, and a subset of patients require long-term therapy. Due to polyvalent cation chelation, prolonged therapy leads to previously underappreciated iron depletion. We conducted a retrospective review of patients treated at the NIH for aplastic anemia, myelodysplastic syndrome, and unilineage cytopenias, comparing those treated with EPAG to a historical cohort treated with immunosuppression without EPAG. We examined iron parameters, duration of therapy, response assessment, relapse rates, and common demographic parameters. We included 521 subjects treated with (n = 315) or without EPAG (n = 206) across 11 studies with multiyear follow-up (3.6 vs. 8.5 years, respectively). Duration of EPAG exposure correlated with ferritin reduction (p = 4 × 10-14 ) regardless of response, maximum dose, or degree of initial iron overload. Clearance followed first-order kinetics with faster clearance (half-life 15.3 months) compared with historical responders (47.5 months, p = 8 × 10-10 ). Risk of iron depletion was dependent upon baseline ferritin and duration of therapy. Baseline ferritin did not correlate with response of marrow failure to EPAG or to relapse risk, and timing of iron clearance did not correlate with disease response. In conclusion, EPAG efficiently chelates total body iron comparable to clinically available chelators. Prolonged use can deplete iron and ultimately lead to iron-deficiency anemia mimicking relapse, responsive to iron supplementation.
EFFECT OF LISTING WEIGHT AND WAITLIST WEIGHT CHANGE ON OUTCOMES IN HEART TRANSPLANT RECIPIENTS: AN ANALYSIS OF THE UNOS DATABASE
Authors: Melissa A. Austin, Jake L. Rosen, Danial Ahmad, Matthew P. Weber, Indranee Rajapreyar, Jesus Eduardo Rame, Rene J. Alvarez, John W. Entwistle, Howard T. Massey, Vakhtang Tchantchaleishvili
Journal: Journal of the American College of Cardiology (2022)
THE INDEX OF MICROCIRCULATORY RESISTANCE STRATIFIES THE PRESENCE OF MICROVASCULAR OBSTRUCTION IN ST-ELEVATION MYOCARDIAL INFARCTION: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Prajith Jeyaprakash, Philopatir Mikhail, Tom J. Ford, Faraz Pathan, Colin Berry, Kazuaki Negishi
Journal: Journal of the American College of Cardiology (2022)
IS IT TIME TO UPDATE THE CLASSIFICATION OF HEART FAILURE AS HEART FAILURE WITH OR WITHOUT EVIDENCE OF SYSTOLIC DYSFUNCTION?
Authors: Matthew Dimond, Nasrien E. Ibrahim, Mitchell A. Psotka, David J. Whellan, Mona Fiuzat, Michael R. Bristow, JoAnn Lindenfeld, Christopher M. O’Connor
Journal: Journal of the American College of Cardiology (2022)
Interventions to reengage people living with HIV who are lost to follow-up from HIV treatment programs: A systematic review and meta-analysis
Authors: Ali Mirzazadeh, Ingrid Eshun-Wilson, Ryan R. Thompson, Atousa Bonyani, James G. Kahn, Stefan D. Baral, Sheree Schwartz, George Rutherford, Elvin H. Geng
Journal: PLoS Medicine (2022)

Optimizing services to facilitate engagement and retention in care of people living with HIV (PLWH) on antiretroviral therapies (ARTs) is critical to decrease HIV-related morbidity and mortality and HIV transmission. We systematically reviewed the literature for the effectiveness of implementation strategies to reestablish and subsequently retain clinical contact, improve viral load suppression, and reduce mortality among patients who had been lost to follow-up (LTFU) from HIV services.
USING ARTIFICIAL INTELLIGENCE TO ACCURATELY QUANTIFY CORONARY ARTERY CALCIFICATIONS ON NON-GATED NON-CONTRAST CT SCANS TO DIAGNOSE INDIVIDUALS WITH HIGH RISK CORONARY ARTERY DISEASE
Authors: Rajus Chopra, Connor C. Kerndt, Daniel F. Summers, Amy Rechenberg, Stefan Jovinge, Thomas F. Boyden, David E. Langholz
Journal: Journal of the American College of Cardiology (2022)
Five-Year Trends in US Children’s Health and Well-being, 2016-2020
Authors: Lydie A. Lebrun-Harris, Reem M. Ghandour, Michael D. Kogan, Michael D. Warren
Journal: JAMA Pediatrics (2022)

Importance Ensuring the well-being of the 73 million children in the United States is critical for improving the nation’s health and influencing children’s long-term outcomes as they grow into adults. Objective To examine recent trends in children’s health-related measures, including significant changes between 2019 and 2020 that might be attributed to the COVID-19 pandemic. Design, Setting, and Participants Annual data were examined from the National Survey of Children’s Health (2016-2020), a population-based, nationally representative survey of randomly selected children. Participants were children from birth to age 17 years living in noninstitution settings in all 50 states and the District of Columbia whose parent or caregiver responded to an address-based survey by mail or web. Weighted prevalence estimates account for probability of selection and nonresponse. Adjusted logistic regression models tested for significant trends over time. Main Outcomes and Measures Diverse measures pertaining to children’s current health conditions, positive health behaviors, health care access and utilization, and family well-being and stressors. Results A total of 174 551 children were included (annual range = 21 599 to 50 212). Between 2016 and 2020, there were increases in anxiety (7.1% [95% CI, 6.6-7.6] to 9.2% [95% CI, 8.6-9.8]; +29%; trend P &amp;amp;lt; .001) and depression (3.1% [95% CI, 2.9-3.5] to 4.0% [95% CI, 3.6-4.5]; +27%; trend P &amp;amp;lt; .001). There were also decreases in daily physical activity (24.2% [95% CI, 23.1-25.3] to 19.8% [95% CI, 18.9-20.8]; −18%; trend P &amp;amp;lt; .001), parent or caregiver mental health (69.8% [95% CI, 68.9-70.8] to 66.3% [95% CI, 65.3-67.3]; −5%; trend P &amp;amp;lt; .001), and coping with parenting demands (67.2% [95% CI, 66.3-68.1] to 59.9% [95% CI, 58.8-60.9]; −11%; trend P &amp;amp;lt; .001). In addition, from 2019 to 2020, there were increases in behavior or conduct problems (6.7% [95% CI, 6.1-7.4] to 8.1% [95% CI, 7.5-8.8]; +21%; P = .001) and child care disruptions affecting parental employment (9.4% [95% CI, 8.0-10.9] to 12.6% [95% CI, 11.2-14.1]; +34%; trend P = .001) as well as decreases in preventive medical visits (83.3% [95% CI, 82.3-84.3] to 78.1% [95% CI, 77.1-79.0]; −6%; trend P &amp;amp;lt; .001). Conclusions and Relevance Recent trends point to several areas of concern that can inform future research, clinical care, policy decision making, and programmatic investments to improve the health and well-being of children and their families. More analyses are needed to elucidate varying patterns within subpopulations of interest.
Lessons learned: next-generation sequencing applied to undiagnosed genetic diseases
Authors: Bryce A. Schuler, Erica T. Nelson, Mary Koziura, Joy D. Cogan, Rizwan Hamid, John A. Phillips
Journal: Journal of Clinical Investigation (2022)

Rare genetic disorders, when considered together, are relatively common. Despite advancements in genetics and genomics technologies as well as increased understanding of genomic function and dysfunction, many genetic diseases continue to be difficult to diagnose. The goal of this Review is to increase the familiarity of genetic testing strategies for non-genetics providers. As genetic testing is increasingly used in primary care, many subspecialty clinics, and various inpatient settings, it is important that non-genetics providers have a fundamental understanding of the strengths and weaknesses of various genetic testing strategies as well as develop an ability to interpret genetic testing results. We provide background on commonly used genetic testing approaches, give examples of phenotypes in which the various genetic testing approaches are used, describe types of genetic and genomic variations, cover challenges in variant identification, provide examples in which next-generation sequencing (NGS) failed to uncover the variant responsible for a disease, and discuss opportunities for continued improvement in the application of NGS clinically. As genetic testing becomes increasingly a part of all areas of medicine, familiarity with genetic testing approaches and result interpretation is vital to decrease the burden of undiagnosed disease.
Clinical outcome in solid organ transplant recipients affected by COVID-19 compared to general population: a systematic review and meta-analysis
Authors: Milo Gatti, Matteo Rinaldi, Linda Bussini, Cecilia Bonazzetti, Renato Pascale, Zeno Pasquini, Francesca Faní, Mariana Nunes Pinho Guedes, Anna Maria Azzini, Elena Carrara, Zaira R. Palacios-Baena, Giulia Caponcello, Eduardo Reyna-Villasmil, Evelina Tacconelli, Jesús Rodríguez-Baño, Pierluigi Viale, Maddalena Giannella, Natascia Caroccia, Federica Arbizzani, Maria Eugenia Giacomini, Oana Vatamanu, Elisa Razzaboni, Maria Elena De Rui, Anna Gorska, Natalia Maldonado, Paula Olivares, David Gutiérrez-Campos, Ana Belén Martín-Gutiérrez, Virginia Palomo, Almudena Serna
Journal: Clinical Microbiology and Infection (2022)
Online interprofessional education for in-service health-care providers improved HIV performance indicators at health facilities in Uganda: a targeted training approach
Authors: Isaac Derick Kimera, Shardrack Wanyina, Martin Muddu, Denis Bwayo, Eleanor Namusoke-Magongo, Nelson K Sewankambo, Fred Collins Semitala
Journal: The Lancet Global Health (2022)

BackgroundThe Makerere University Education for Interprofessional HIV Service Delivery in Uganda capacity-building programme provides online, in-service interprofessional education to HIV health-care providers through a case-based approach. We used this training to address suboptimal performance among health-care providers.MethodsWe used a multilayered integrated training and impact assessment on HIV health outcomes. In partnership with a Ugandan organisation implementing the US President's Emergency Plan for AIDS Relief, we identified health facilities underperforming on selected HIV programme indicators: pre-exposure retention at 12 months for key populations and viral load suppression and annual retention for key populations, which could be aligned with the training modules. We selected health-care providers committed to completing the interprofessional education training and application of interprofessional practice at their workstations from five health facilities. Selected health-care providers were enrolled for the Makerere University Education for Interprofessional HIV Service Delivery in Uganda online training programme.FindingsOf the health-care providers enrolled (n=55), 32 (58%) were women; 17 (31%) were nurses; 9 (16%) were clinical officers; 8 (15%) were counsellors; 6 (11%) were medical officers; 5 (9%) were data clerks; 4 (7%) were laboratory personnel; and 6 (11%) included social workers, records officers, and dispensers. 45 (82%) health-care providers completed the training, and four of the five health facilities initiated quality improvement projects aligned with baseline indicators. The percentage of pre-exposure retention at 12 months improved from 4% to 80%; the percentage of viral load coverage for key populations improved from 50% to 94%; the percentage of viral load suppression improved from 80% to 96%; and the percentage of annual retention for key populations improved from 63% to 85%.InterpretationIn-service and online interprofessional education training, interprofessional practice mentorship, and continuous quality improvement for HIV care improved HIV programme indicators. A multilevel stakeholder engagement strategy was associated with strengthened training and enhanced potential for sustainability and impact on patient outcomes.FundingHuman Resources Services Administration through award 6U1NHA31422-02-04 to University of California San Francisco and African Forum for Research and Education in Health.
Federated analysis of BRCA1 and BRCA2 variation in a Japanese cohort
Authors: James Casaletto, Michael Parsons, Charles Markello, Yusuke Iwasaki, Yukihide Momozawa, Amanda B. Spurdle, Melissa Cline
Journal: Cell Genomics (2022)

More than 40% of the germline variants in ClinVar today are variants of uncertain significance (VUSs). These variants remain unclassified in part because the patient-level data needed for their interpretation is siloed. Federated analysis can overcome this problem by “bringing the code to the data”: analyzing the sensitive patient-level data computationally within its secure home institution and providing researchers with valuable insights from data that would not otherwise be accessible. We tested this principle with a federated analysis of breast cancer clinical data at RIKEN, derived from the BioBank Japan repository. We were able to analyze these data within RIKEN’s secure computational framework without the need to transfer the data, gathering evidence for the interpretation of several variants. This exercise represents an approach to help realize the core charter of the Global Alliance for Genomics and Health (GA4GH): to responsibly share genomic data for the benefit of human health.
MIGRAINE HEADACHE IN PATIENTS WITH SPONTANEOUS CORONARY ARTERY DISSECTION: A REPORT OF THE ISCAD REGISTRY
Authors: Bryan J. Wells, Malissa J. Wood, Anna Grodzinsky, Heather L. Gornik, Daniella Kadian-Dodov, Angela M. Taylor, Connie Ng Hess, Jennifer Lewey, Stanislav Henkin, Gretchen L. Wells, Lori Tam, Clara Vitarello, Fahad Alkhalfan, Gerald Chi, C. Michael Gibson, Katherine Leon, Sahar Naderi, Soo Hyun Kim
Journal: Journal of the American College of Cardiology (2022)