tbuckley/cabot-search huggingface dataset:
Better Therapeutic Approach after Comprehensive Geriatric Evaluation in Older Patients with ACUTE Myeloid Leukemia and Myelodysplasic Syndromes
Authors: Damir Blazevic, Helena Pomares, Concepcion Boque, Mercedes Galiano, Clara Maluquer, Silvia Murcia, Anna Sureda, Maite Antonio, Montserrat Arnan
Journal: Blood (2021)
Inhaled curcumin mesoporous polydopamine nanoparticles against radiation pneumonitis
Authors: Ting Chen, Bo Zhuang, Yueqi Huang, Yan Liu, Bochuan Yuan, Wanmei Wang, Tianyu Yuan, Lina Du, Yiguang Jin
Journal: Acta Pharmaceutica Sinica B (2021)

Radiation therapy is an effective method to kill cancer cells and shrink tumors using high-energy X-ray or γ-ray. Radiation pneumonitis (RP) is one of the most serious complications of radiation therapy for thoracic cancers, commonly leading to serious respiratory distress and poor prognosis. Here, we prepared curcumin-loaded mesoporous polydopamine nanoparticles (CMPN) for prevention and treatment of RP by pulmonary delivery. Mesoporous polydopamine nanoparticles (MPDA) were successfully synthesized with an emulsion-induced interface polymerization method and curcumin was loaded in MPDA via π‒π stacking and hydrogen bonding interaction. MPDA owned the uniform spherical morphology with numerous mesopores that disappeared after loading curcumin. More than 80% curcumin released from CMPN in 6 h and mesopores recovered. CMPN remarkably protected BEAS-2B cells from γ-ray radiation injury by inhibiting apoptosis. RP rat models were established after a single dose of 15 Gy 60Co γ-ray radiation was performed on the chest area. Effective therapy of RP was achieved by intratracheal administration of CMPN due to free radical scavenging and anti-oxidation ability, and reduced proinflammatory cytokines, high superoxide dismutase, decreased malondialdehyde, and alleviated lung tissue damages were observed. Inhaled CMPN paves a new avenue for the treatment of RP.
Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) in Pediatric Patients with Tagraxofusp, a CD123-Targeted Therapy
Authors: Naveen Pemmaraju, Branko Cuglievan, Joseph L Lasky, Albert Kheradpour, Nobuko Hijiya, Anthony S. Stein, Anna B Pawlowska
Journal: Blood (2021)
Abstract 9311: Heart Rate Modulates the Relationship of Augmented Systolic Blood Pressure With the Blood Natriuretic Peptide Levels
Authors: Hirofumi Tomiyama, Shiina Kazuki, Hiroki Nakano, Masatsune Fujii, Chisa Matsumoto, taka taka, Taishiro Chikamori, Akira Yamashina
Journal: Circulation (2021)

Introduction: Augmented central systolic blood pressure (cSBP), which is known to affect the cardiac afterload, is an independent risk factor for cardiovascular disease. While an inverse relationship is known to exist between the heart rate (HR) and cSBP, it has not yet been clarified if the HR also modulates the association between the cSBP and the cardiac afterload. Hypothesis: The present study was conducted to clarify whether the association of the cSBP with the serum levels of the N-terminal fragment B-type natriuretic peptide (NT-proBNP) differs between subjects with high and low HRs, using data obtained from the same subjects on two occasions (2009 and 2012) so as to confirm their consistency. Methods: The data analyzed in this study were the radial augmentation index (radial AI), systolic pressure at the second peak of the radial pressure waveform (SBP2), and serum NT-proBNP levels measured in a worksite cohort of 2000 middle-aged men in 2009 and in 2012. Results: For the purpose of this study, the subjects were divided into three groups by the HR (i.e., -69, 70-79, and -80 beats/minute). While the serum NT-proBNP levels were similar among the three groups, the radial AI increased and the SBP1-2 decreased significantly with decreasing HR ( P = 0.01). After the adjustment, the SBP2 showed a significant association with the serum NT-proBNP levels in the overall study population {Non-standardized co-efficient (B) = 0.005, Standard error (SE) = 0.001, P 0.01 in 2009 (n = 2257), and B = 0.004, SE = 0.001, P = 0.01 in 2012 (n = 1986)}. In subgroup analyses, the SBP2 showed a significant association with the serum NT-proBNP levels {B = 0.004, SE = 0.002, P =0.02 in 2009 (n = 1291) and B = 0.005, SE = 0.001, P = 0.01 in 2012 (n = 1204)} only in the subject group with a HR of -69 beats/min. Conclusions: In middle-aged Japanese men, the relationship between the cSBP and the cardiac afterload appears to differ depending on the heart rate; the results of our analysis showed that the relationship between the cSBP and cardiac overload may be more pronounced and strongly significant in patients with low HRs as compared to patients with high HRs.
Molecular Characteristics of Response to Olutasidenib (FT-2102) in Patients with Relapsed/Refractory mIDH1 Acute Myeloid Leukemia
Authors: Stephane De Botton, Karen Yee, Christian Recher, Andrew H. Wei, Pau Montesinos, David Taussig, Arnaud Pigneux, Thorsten Braun, Antonio Curti, Jordi Esteve, Carolyn Grove, Brian A. Jonas, Asim Khwaja, Olivier Legrand, Pierre Peterlin, Montserrat Arnan Sangerman, William G. Blum, Daniela Cilloni, Devendra Hiwase, Joseph G. Jurcic, Jürgen Krauter, Xavier Thomas, Justin Watts, Jay Yang, Zihao Xin, Alex Sedkov, Sylvie Guichard, Jennifer Sweeney, Christophe Marzac, Jorge E. Cortes, Pierre Fenaux
Journal: Blood (2021)
Proteogenomic Characterization of Highly Enriched Viable Leukemic Blasts in Acute Myeloid Leukemia: A SWOG Report
Authors: Jasmine Naru, Megan Othus, ChenWei Lin, Anna Moseley, Cheryl L Willman, Era L Pogosova-Agadjanyan, Feinan Wu, Frederick R. Appelbaum, Harry P. Erba, Isaac C. Jenkins, Jacob J Kennedy, Jeffrey Delrow, Jeffrey Whiteaker, Jerald P. Radich, John E. Godwin, Lan Beppu, Matthew Fitzgibbon, Min Fang, Pei Wang, Phillip R Gafken, Richard G Ivey, Soheil Meshinchi, Thomas R. Chauncey, Travis D Lorentzen, Uliana J Voytovich, Amanda G Paulovich, Derek Stirewalt
Journal: Blood (2021)
Spectrum of Molecular Modes of Immune Escape in Idiopathic Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria
Authors: Simona Pagliuca, Carmelo Gurnari, Colin Hercus, Niroshan Nadarajah, Adam Wahida, Laila Terkawi, Sunisa Kongkiatkamon, Misam Zawit, Tariq Kewan, Waled Bahaj, Babal K. Jha, Yihong Guan, Minako Mori, Caiying Zhu, Valeria Visconte, Ping Zhu, Torsten Haferlach, Jaroslaw P. Maciejewski
Journal: Blood (2021)
Management of Edoxaban Therapy in Patients Undergoing Major Surgery: A Sub-Analysis of the Prospective, Observational, Multinational Emit-AF/VTE Study
Authors: Christian von Heymann, Martin Unverdorben, Paolo Colonna, Amparo Santamaria Ortiz, Manish Saxena, Thomas Vanassche, Jeffrey I. Weitz, Robert Wilkins, Cathy Chen
Journal: Blood (2021)
Characterization of Somatic Mosaicism and Mutational Profiling of Clonal Hematopoiesis Compared to MDS and sAML Depicts Diversities of Clonal Evolution
Authors: Judith S. Hecker, Luise Hartmann, Maja Rothenberg-Thurley, Jennifer Rivière, Bianka Ksienzyk, Michele C. Buck, Mark Van Der Garde, Luise Fischer, Susann Winter, Martina Rauner, Elena Tsourdi, Katja Sockel, Marie Schneider, Anne Sophie Kubasch, Martin Nolde, Dominikus Hausmann, Jörg Lützner, Andreas Roth, Florian Bassermann, Karsten Spiekermann, Lorenz Hofbauer, Uwe Platzbecker, Klaus H. Metzeler, Katharina S. Goetze
Journal: Blood (2021)
Evolutionary Processes in the Emergence and Recent Spread of the Syphilis Agent,<i>Treponema pallidum</i>
Authors: Marta Pla-Díaz, Leonor Sánchez-Busó, Lorenzo Giacani, David Šmajs, Philipp P Bosshard, Homayoun C Bagheri, Verena J Schuenemann, Kay Nieselt, Natasha Arora, Fernando González-Candelas
Journal: Molecular Biology and Evolution (2021)

Abstract The incidence of syphilis has risen worldwide in the last decade in spite of being an easily treated infection. The causative agent of this sexually transmitted disease is the bacterium Treponema pallidum subspecies pallidum (TPA), very closely related to subsp. pertenue (TPE) and endemicum (TEN), responsible for the human treponematoses yaws and bejel, respectively. Although much focus has been placed on the question of the spatial and temporary origins of TPA, the processes driving the evolution and epidemiological spread of TPA since its divergence from TPE and TEN are not well understood. Here, we investigate the effects of recombination and selection as forces of genetic diversity and differentiation acting during the evolution of T. pallidum subspecies. Using a custom-tailored procedure, named phylogenetic incongruence method, with 75 complete genome sequences, we found strong evidence for recombination among the T. pallidum subspecies, involving 12 genes and 21 events. In most cases, only one recombination event per gene was detected and all but one event corresponded to intersubspecies transfers, from TPE/TEN to TPA. We found a clear signal of natural selection acting on the recombinant genes, which is more intense in their recombinant regions. The phylogenetic location of the recombination events detected and the functional role of the genes with signals of positive selection suggest that these evolutionary processes had a key role in the evolution and recent expansion of the syphilis bacteria and significant implications for the selection of vaccine candidates and the design of a broadly protective syphilis vaccine.
Trial-in-Progress: Randomized Phase II Trial in Early Relapsing or Refractory Follicular Lymphoma (NCT#03269669): SWOG S1608
Authors: Paul M. Barr, Hongli Li, Brian K. Link, Christopher R. Flowers, Richard Burack, Heiko Schöder, Michael L. Leblanc, Oliver Weigert, Alex F. Herrera, David M. Weinstock, John P. Leonard, Brad S. Kahl, Sonali M. Smith, Jonathan W. Friedberg
Journal: Blood (2021)
A Third Anti-Sars-Cov2 mRNA Dose Does Not Overcome the Pejorative Impact of Anti-CD20 Therapy and/or Low Immunoglobulin Level in CLL/Lymphoma Patients
Authors: Maureen Chbat, Milena Kohn, Fatiha Merabet, Anne-Laure Roupie, Naelle Lombion, Amina Guemriche, Stéphanie Marque-Juillet, Victoria Raggueneau, Jennifer Osman, Marc Spentchian, Marc Delord, Sophie Rigaudeau, Caroline Besson
Journal: Blood (2021)
Abstract 9442: Acute Coronary Syndrome Treatment Delay in Low to Middle-Income Countries: A Systematic Review
Authors: Lemlem Demisse, Sharon L. Leslie, Bekele Alemayehu, Gary Rebecca
Journal: Circulation (2021)

Introduction: Although morbidity and mortality rates are declining for acute coronary syndrome (ACS) in most high-income countries, it is rising at an alarming pace for low to middle-income countries (LMICs), largely due to pre-hospital treatment delays. Purpose: This systematic review was conducted to determine the mean length of time from symptom onset to treatment in LMICs and the sociodemographic, clinical, and health system characteristics that contribute to treatment delays. Methods: A comprehensive review of the English literature was conducted between January 1990 through May 2020 using predefined criteria. Time to treatment was defined from ACS symptom onset to first medical contact and then further dichotomized as less than (early) or greater than 12-hours (late) treatment. Twenty-nine peer-reviewed studies, which comprised 29,731 subjects with ACS symptoms residing in 14 LMICs. Sample sizes in the studies ranged from 50 to 20,937. Age ranged from 28-72 years and the majority were males. The Newcastle-Ottawa Assessment Scale was utilized to measure study quality. Results: The mean time from symptom onset to first medical contact was 12.7 hours, ranging from10-minutes to 96 hours. Being older age, female gender, illiterate, rural residence, having atypical chest pain and lack of ACS symptom knowledge were associated with longer delays. Those directly admitted to an emergency department with the capacity to provide coronary interventions received earlier treatment. Community facilities where ECG machines were available had lower prehospital delay time for referral to reperfusion therapy facilities. Lack of emergency medical systems, poor communication between the community and interventional facilities were also major contributors to ACS treatment delays. Conclusions: Pre-hospital delay time remains an important contributor to poorer clinical outcomes and higher mortality in LMICs. Country-wide referral plans are urgently needed to ensure timely transfer of patients from non-cardiac centers to interventional facilities. Health education through the different media outlets will raise awareness of ACS risk factors, accompanying signs and symptoms as well as the need to seek early treatment to improve clinical outcomes.
Abstract 12339: Robotic Assistance Improves Cardiovascular Function Compared To Conventional Cardiac Rehabilitation Programs
Authors: Bahar Irfan, Nathalia Cespedes Gomez, Jonhatan A Casas, Emmanuel Senft, Daniel Sanchez, MONICA RINCON-RONCANCIO, LUISA FERNANDA F GUTIERREZ, Carlos Cifuentes, Belpaeme Tony, Marcela Munera
Journal: Circulation (2021)

Introduction: This study investigates the impact of socially assistive robots and personalization in cardiac rehabilitation, in terms of physiological progress and perceptions of the patients and clinicians. Methods: We conducted a longitudinal study for 2.5 years with 43 patients. The intervention was classified into 3 conditions: control group (without a robot), a social robot and a personalized robot. Throughout the rehabilitation program (36 sessions), the initial heart rate, average heart rate during training, and heart rate recovery in the first minute. Heart rate recovery in the first minute was normalized with initial heart rate to homogenize the data: Heart rate recovery in the first minute normalized = heart rate recovery in the first minute/ initial heart rate. We apply Johansen's general formulation of the Welch-James statistic with approximate degrees of freedom on Heart rate recovery in the first minute normalized in 6 stages. Perceptions of the patients and clinicians are evaluated through surveys and interviews. Results: 26 patients completed the rehabilitation program. Heart rate recovery in the first minute normalized changed significantly in each stage of the program (TWJ (5, 305) = 14.36, p &lt; .001). Patients assisted by social and personalized robots achieved a higher improvement in cardiovascular functioning than the control group. Both robots improved motivation and trust due to continuous monitoring and immediate feedback, facilitated prompt detection of critical conditions, and were recommended for future use by clinicians and patients. Conclusions: Our results suggest that robots improve cardiovascular functioning compared to the conventional cardiac rehabilitation program. In addition, robots have motivational benefits for patients, and increase awareness of clinicians to detect complications, as a result, they were recommended for future use by patients and clinicians.
Self-testing for HIV could increase diagnoses in the trans community
Authors: Helen Saul, Deniz Gursul
Journal: BMJ (2021)

The study Witzel TC, Wright T, McCabe L, et al. Impact and acceptability of HIV self-testing for trans men and trans women: A mixed-methods subgroup analysis of the SELPHI randomised controlled trial and process evaluation in England and Wales. EClinicalMedicine 2021;32:100700. To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/hiv-self-testing-increases-diagnoses-trans-people/
PET2 Response Associated with Survival in Newly Diagnosed Diffuse Large B-Cell Lymphoma: Results of Two Independent Prospective Cohorts
Authors: Sanjal H Desai, Levi D. Pederson, Betsy Laplant, Raphael Mwangi, Matthew J. Maurer, Jason R. Young, William R. Macon, Rebecca L. King, Yucai Wang, James R. Cerhan, Andrew L. Feldman, David J. Inwards, Ivana N. Micallef, Patrick B. Johnston, Luis F. Porrata, Stephen M. Ansell, Thomas M. Habermann, Thomas E. Witzig, Grzegorz S. Nowakowski
Journal: Blood (2021)
Abstract 14133: Hepatic Deletion of the Cargo Receptor Surf4 Causes Marked Hypocholesterolemia in Mice
Authors: Vi T Tang, Brian T Emmer, Joseph McCormick, David Ginsburg
Journal: Circulation (2021)

Introduction: High plasma concentration of low-density lipoprotein (LDL) is a strong risk factor for coronary artery diseases. Circulating LDL level is a balance between the secretion of its precur...
Low Dose Apixaban As Secondary Prophylaxis for Venous Thromboembolism in Cancer Patients, 30 Months Follow-up
Authors: Trine-Lise Hannevik, Herish Garresori, Jorunn Brekke, Tone Ronnaug Enden, Hege Froen, Eva-Marie Jacobsen, Petter Quist-Paulsen, Alina Carmen Porojnicu, Anne Hansen Ree, Dag Torfoss, Elin Velle, Hilde Skuterud Wik, Waleed Ghanima, Per Morten Sandset, Anders EA Dahm
Journal: Blood (2021)
Idecabtagene Vicleucel (ide-cel, bb2121), a B-Cell Maturation Antigen-Directed Chimeric Antigen Receptor T Cell Therapy: Qualitative Analyses of Post-Treatment Interviews (Months 6-24) for Patients with Relapsed and Refractory Multiple Myeloma in the Karmma Clinical Trial
Authors: Nina Shah, Michel Delforge, Paula Rodríguez-Otero, Olga Moshkovich, Julia Braverman, Devender Dhanda, Sally Lanar, Jennifer Devlen, Matthew Miera, Heather Gerould, Timothy B. Campbell, Nikhil C. Munshi
Journal: Blood (2021)
Therapeutic Targeting of CD74 with STRO-001 Antibody-Drug Conjugate in AML and ALL
Authors: Quy Le, Amanda R. Leonti, Thao T. Tang, Sommer Castro, Cynthia Nourigat-Mckay, LaKeisha Perkins, Rhonda E. Ries, Jenny L. Smith, Tiffany A. Hylkema, Laura Pardo, Cristina Abrahams, Kristin Bedard, Arturo Molina, Lisa Eidenschink Brodersen, Michael R. Loken, Soheil Meshinchi
Journal: Blood (2021)
Clinical Utility and Physician Perceptions of a Digital Platform for Electronic Patient-Reported Outcomes Monitoring in Patients with Hematologic Malignancies in Real-World Practice
Authors: Fabio Efficace, Massimo Breccia, Giovanni Caocci, Leonardo Potenza, Ida Carmosino, Francesca Fazio, Maria Teresa Petrucci, Isabella Capodanno, Francesco Cottone, Alice Di Rocco, Caterina Patti, Valeria Pioli, Elisabetta Colaci, Davide Giusti, Elisabetta Lugli, Luigi Rigacci, Michelina Santopietro, Fulvia Fanelli, Agostino Tafuri, Maria Paola Bianchi, Claudio Cartoni, Giusy Antolino, Esmeralda Conte, Edoardo La Sala, Massimo Pini, Claudio Fozza, Sergio Siragusa, Marco Santoro, Salvatrice Mancuso, Paolo De Fabritiis, Nicolina Rita Ardu, Pasquale Niscola, Andrea Patriarca, Ombretta Annibali, Mario Luppi, Paola Fazi, Marco Vignetti
Journal: Blood (2021)
Preferences for Accessing Patient Reported Outcomes and Health Information Among Thrombotic Thrombocytopenic Purpura Survivors
Authors: Deirdra Terrell, Rachel Ann Kelley, Amanda J Llaneza, Sara K. Vesely, Janna Journeycake, Mohamad O. Khawandanah, Marshall Mazepa, Frank Akwaa, Adam Cuker, Shruti Chaturvedi, Neil A. Zakai, Ming Yeong Lim, Radhika Gangaraju, Spero Cataland
Journal: Blood (2021)
Mir-671-5p, Mir-193b-5p, Mir-1307-5p Are Useful for Predicting Outcome in Diffuse Large B-Cell Lymphoma
Authors: Aditi Sharma, Ashim Das, Amanjit Bal, Radhika Srinivasan, Pankaj Malhotra, Gaurav Prakash, Rajender Kumar
Journal: Blood (2021)
SIRT6 protects vascular smooth muscle cells from osteogenic transdifferentiation via Runx2 in chronic kidney disease
Authors: Wenxin Li, Weijing Feng, Xiaoyan Su, Dongling Luo, Zhibing Li, Yongqiao Zhou, Yongjun Zhu, Mengbi Zhang, Jie Chen, Baohua Liu, Hui Huang
Journal: Journal of Clinical Investigation (2021)

Vascular calcification (VC) is regarded as an important pathological change lacking effective treatment and associated with high mortality. Sirtuin 6 (SIRT6) is a member of the Sirtuin family, a class III histone deacetylase and a key epigenetic regulator. SIRT6 has a protective role in patients with chronic kidney disease (CKD). However, the exact role and molecular mechanism of SIRT6 in VC in patients with CKD remain unclear. Here, we demonstrated that SIRT6 was markedly downregulated in peripheral blood mononuclear cells (PBMCs) and in the radial artery tissue of patients with CKD with VC. SIRT6-transgenic (SIRT6-Tg) mice showed alleviated VC, while vascular smooth muscle cell–specific (VSMC-specific) SIRT6 knocked-down mice showed severe VC in CKD. SIRT6 suppressed the osteogenic transdifferentiation of VSMCs via regulation of runt-related transcription factor 2 (Runx2). Coimmunoprecipitation (co-IP) and immunoprecipitation (IP) assays confirmed that SIRT6 bound to Runx2. Moreover, Runx2 was deacetylated by SIRT6 and further promoted nuclear export via exportin 1 (XPO1), which in turn caused degradation of Runx2 through the ubiquitin-proteasome system. These results demonstrated that SIRT6 prevented VC by suppressing the osteogenic transdifferentiation of VSMCs, and as such targeting SIRT6 may be an appealing therapeutic target for VC in CKD.
Systemic Inflammation Response Index (SIRI) Predicts Clinical Outcome and Improves NCCN-IPI Scoring in Primary Gastrointestinal Diffuse Large B-Cell Lymphoma
Authors: Yurou Chu, Xiangxiang Zhou, Yingyue Liu, Linquan Zhan, Xiaosheng Fang, Ying Li, Xin Wang
Journal: Blood (2021)
Assessment of Next Generation Sequencing Approaches for the Cytogenetic and Molecular Evaluation of Acute Myeloid Leukemia
Authors: Laura W. Dillon, Xijun Zhang, Meghali Goswami, Gauthaman Sukumar, Jack Ghannam, Katherine E. Lindblad, Adam Sciambi, Robert Durruthy-Durruthy, Clifton L. Dalgard, Matthew D. Wilkerson, Christopher S. Hourigan
Journal: Blood (2021)
Abstract 9402: Venous Thromboembolism During Pregnancy is Associated with Elevated Tricuspid Regurgitation Velocity in Sickle Cell Disease
Authors: William H Marshall, Erin M Cleary, Sherraine Della-Moretta, Philip Samuels, Payal Desai, Saurabh Rajpal
Journal: Circulation (2021)

Introduction: In patients with sickle cell disease (SCD), a tricuspid regurgitation velocity (TRV) &gt; 2.5 m/s by echocardiogram is a non-invasive marker for underlying pulmonary hypertension (PH), and associated with increased mortality. During pregnancy, maternal and fetal adverse events are increased in women SCD, and in women with PH. Data on pregnancy outcomes in women with both SCD and elevated TRV are sparse; we hypothesized increased adverse events in this group. Methods: We retrospectively compared pregnancy outcomes in women with SCD and elevated TRV (&gt;2.5 m/s) to those with SCD and normal TRV (≤ 2.5 m/s). Results: We identified 59 pregnancies in 43 women (mean age 28 ± 5 years at delivery) with SCD (31 pregnancies in women with elevated TRV, 28 with normal TRV). There was a trend towards more lifetime transfusions, and significantly lower hemoglobin in women with elevated TRV ( Figure A-B ). As expected, right ventricular systolic pressure was different between the groups, however other baseline characteristics, including SCD genotype, left ventricular systolic function, and pre-pregnancy venous thromboembolism (VTE) were similar ( Figure C-F ). No maternal deaths occurred in pregnancy or 1-year postpartum. VTE occurred in 7 (12%) pregnancies, only in women with elevated TRV; and postpartum readmission was more common in women with elevated TRV ( Figure G ). Other cardiac and hematologic outcomes occurred with similar incidence between the groups ( Figure G ). In viable pregnancies, preterm birth was more common in women with elevated TRV, while other adverse obstetric and fetal outcomes did not differ between the groups ( Figure G ). Conclusion: In conclusion, we identified a higher incidence of VTE, preterm birth and postpartum readmission in pregnant women with SCD and elevated TRV. These complications may be associated with worse SCD burden; however, the potential mechanistic link between pregnancy, VTE and PH as assessed by elevated TRV requires further study.