tbuckley/cabot-search huggingface dataset:
Cimetidine and Eosinophilic Fasciitis
Authors: FRANCISCO JAVIER LASO
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 June 1983Cimetidine and Eosinophilic FasciitisFRANCISCO JAVIER LASO, M.D., ISABEL PASTOR, M.D., SISINIO DE CASTRO, M.D.FRANCISCO JAVIER LASO, M.D.Search for more papers by this author, ISABEL PASTOR, M.D.Search for more papers by this author, SISINIO DE CASTRO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-6-1026_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Eosinophilic fasciitis is a scleroderma-like syndrome, described by Shulman in 1974 (1). Although for most patients, corticosteroid treatment has been effective, no improvement has been seen in others. Solomon and associates (2) recently reported cimetidine to be effective treatment for patients with eosinophilic fasciitis. Loftin (3) subsequently reported a lack of improvement with cimetidine in one patient.We studied a 57-year-old woman with eosinophilic fasciitis (4), who had been treated with steroids for 3 years. Skin induration of both limbs had not improved and led to a progressive decrease in ankle and wrist movements. Also, morphea-like plaques...References1. SHULMAN L. Diffuse fasciitis with hypergammaglobulinemia and eosinophilia: a new syndrome? [Abstract]. J Rheum. 1974;1(suppl 1):46. Google Scholar2. SOLOMONBARLANDRIFKIN GPH. Eosinophilic fasciitis responsive to cimetidine. Ann Intern Med. 1982;97:547-9. LinkGoogle Scholar3. LOFTIN E. Cimetidine and eosinophilic fasciitis [Letter]. Ann Intern Med. 1983;97:111-2. LinkGoogle Scholar4. LASOAPARICIODIEZ-JARILLAGONZALEZ-MACIAS FMJJ. A new case of eosinophilic fasciitis. Dermatologica. 1980;161:211-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hospital Clinico Universitario Salamanca Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEosinophilic Fasciitis in a Pediatric PatientEosinophilic fascilitis with myelodysplasia responsive to treatment with cyclosporinKetotifen - a therapeutic agent of eosinophilic fasciitis?The fasciitis-panniculitis syndrome: Clinical spectrum and response to cimetidineInflammatory Pseudotumor of the NeckTreatment with cimetidine of atypical fasciitis panniculitis syndrome.Cimetidine in Eosinophilie FasciitisHerson Serge, MD, Sabine Brechignac, MD, Godeau Pierre, MDEosinophilic fasciitis: Clinical spectrum and therapeutic response in 52 casesDermatologic therapy: December, 1982, through November, 1983 1 June 1983Volume 98, Issue 6Page: 1026-1026KeywordsAnklesPatientsSteroids Issue Published: 1 June 1983 PDF downloadLoading ...
Angiotensin III: (DES-Aspartic Acid-1)-Angiotensin II. Evidence and speculation for its role as an important agonist in the renin - angiotensin system.
Authors: T LGoodfriend, M JPeach
Journal: Circulation Research (1975)

Evidence is reviewed that three and possibly four peptides formed from renin substrate have biological activity that merits their recognition as agonists. The decepeptide angiotensin I affects sites in the central nervous system and adrenal medulla. The octapeptide angiotensin II affects vascular and cardiac sites that mediate acute pressor responses, and also causes direct feedback inhibition of renin release. The heptapeptide (des-asp-1)-angiotensin II (angiotensin III) stimulates aldosterone release.. It may exert its effects intracellularly at the adrenal glomerulosa and other sites. The fourth candidate is the (des-asp-1)-angiotensin I nonapeptide, but nothing is known of its activity or circulating levels. This formulation of the angiotensin reaction sequence and the effects of its individual congeners suggests several experiments. It also permits simple explanations for previously confusing data, such as the inability of immunization and anti-angiotensin II to prevent aldosterone responses, and t...
Effect of activation of the H1 receptor on coronary hemodynamics in man.
Authors: CVigorito, SPoto, G BPicotti, MTriggiani, GMarone
Journal: Circulation (1986)

We evaluated the effects of selective activation of H1 receptors on coronary hemodynamics in 16 patients divided into two groups: group A, 11 patients with atypical angina or valvular heart disease and normal coronary arteries, and group B, five patients with spontaneous angina, four of whom had significant (greater than 70% stenosis) coronary artery disease and one with normal coronaries. Selective H1 receptor stimulation was achieved by infusing 0.5 microgram/kg/min of histamine intravenously for 5 min after pretreatment with cimetidine (25 mg/kg). Heart rate was maintained constant (100 beats/min) by coronary sinus pacing and coronary blood flow (CBF) was measured by thermodilution. In group A, during histamine infusion mean aortic pressure fell from 99 +/- 5 to 77 +/- 4 mm Hg (mean +/- SEM, p less than .001), coronary vascular resistance (CVR) decreased from 1.07 +/- 0.17 to 0.82 +/- 0.14 mm Hg/ml/min (p less than .02), and CBF and myocardial oxygen consumption remained unchanged. None of the patients...
Low-Dose Interleukin-2 Therapy Activates Circulating T Follicular Regulatory Cells and Suppresses Circulating T Follicular Helper Cells in Patients with Chronic Gvhd
Authors: Yusuke Kamihara, Edouard Forcade, John Koreth, Hongye Liu, Tomohiro Kubo, Jennifer Whangbo, Masahiro Hirakawa, Sarah Nikiforow, Vincent T Ho, Philippe Armand, Corey S. Cutler, Edwin Alyea, Bruce Blazar, Joseph H. Antin, Robert J. Soiffer, Jerome Ritz
Journal: Blood (2017)
Biological functions of therapy-induced senescence in cancer
Authors: Eleni Fitsiou, Abel Soto-Gamez, Marco Demaria
Journal: Seminars in Cancer Biology (2021)

Therapy-induced cellular senescence is a state of stable growth arrest induced by common cancer treatments such as chemotherapy and radiation. In an oncogenic context, therapy-induced senescence can have different consequences. By blocking cellular proliferation and by facilitating immune cell infiltration, it functions as tumor suppressive mechanism. By fueling the proliferation of bystander cells and facilitating metastasis, it acts as a tumor promoting factor. This dual role is mainly attributed to the differential expression and secretion of a set of pro-inflammatory cytokines and tissue remodeling factors, collectively known as the Senescence-Associated Secretory Phenotype (SASP). Here, we describe cell-autonomous and non-cell-autonomous mechanisms that senescent cells activate in response to chemotherapy and radiation leading to tumor suppression and tumor promotion. We present the current state of knowledge on the stimuli that affect the activation of these opposing mechanisms and the effect of senescent cells on their micro-environment eg. by regulating the functions of immune cells in tumor clearance as well as strategies to eliminate senescent tumor cells before exerting their deleterious side-effects.
Abnormal neuroendocrine responses during exercise in heart transplant recipients.
Authors: R WBraith, C EWood, M CLimacher, M LPollock, D TLowenthal, M IPhillips, E DStaples
Journal: Circulation (1992)

BACKGROUNDOsmotic and neural factors stimulate neuroendocrine activity during exercise. In contrast to excitatory mechanisms, afferent information from cardiac mechanoreceptors inhibits integrative centers in the hypothalamus and medula oblongata, which serves to buffer neuroendocrine activity. Orthotopic cardiac transplantation results in the loss of afferent information from cardiac mechanoreceptors. Thus, transplantation possibly results in exaggerated neuroendocrine responses when patients are physically active.METHODS AND RESULTSWe measured the neuroendocrine response to moderate and strenuous exercise performed at the same relative intensity in 11 heart transplant recipients (50 +/- 14 years old) 18 +/- 12 months after transplantation and 11 control subjects matched with respect to sex, age, and body size. Plasma levels of norepinephrine, vasopressin, renin activity, atrial natriuretic peptide, angiotensin II, and aldosterone were measured at rest, during a maximal graded exercise test, and during s...
Limitation of myocardial infarction by early infusion of recombinant tissue-type plasminogen activator.
Authors: MO'Rourke, DBaron, AKeogh, RKelly, GNelson, CBarnes, JRaftos, KGraham, KHillman, HNewman
Journal: Circulation (1988)

In a double-blind randomized trial involving five Sydney hospitals and the city ambulance paramedical service, 145 patients with a first evolving myocardial infarction and with onset of pain less than 2.5 (mean 1.9 +/- 0.5 [SD]) hr previously were allocated to intravenous infusion of 100 mg recombinant tissue-type plasminogen activator (rt-PA) or placebo over 3 hr. The groups at entry were similar. At assessment 21 days later, left ventricular ejection fraction measured both by contrast and radionuclide ventriculography was higher in the rt-PA compared with the placebo group (61 +/- 13%, n = 64, vs 54 +/- 14%, n = 62, contrast, 2p = .006; 52 +/- 13%, n = 66, vs 48 +/- 13%, n = 62 isotope, 2p = .08). This indicates limitation of myocardial infarction by rt-PA.
Effects of the pericardium on the diastolic left coronary pressure-flow relationship in the isolated dog heart.
Authors: JWatanabe, YMaruyama, SSatoh, MKeitoku, TTakishima
Journal: Circulation (1987)

We studied the effects of the pericardium on diastolic left coronary pressure-flow relationships in heart-blocked and isolated canine preparations. In these preparations, the left and right coronary arteries were dilated with adenosine and perfused by means of a pressurized arterial reservoir. The diastolic left heart pressure (LHP) was controlled by the height of a reservoir connected to the left atrium and left ventricle. The right atrial and ventricular pressure i.e., coronary outflow pressure, was kept constant at 0 mm Hg. Before and after pericardiectomy, diastolic coronary pressure-flow relationships were obtained at three values of LHP (0, 15, and 30 mm Hg) with driving pressure decreasing (2 mm Hg/sec or less) from approximately 60 mm Hg to the actual zero-flow pressure (Pf = 0) during a single long diastole induced by cessation of ventricular pacing. The slopes of the coronary pressure-flow relationships were approximated by a linear regression analysis in which the correlation coefficients were ...
Age-induced decreases in the messenger RNA coding for the sarcoplasmic reticulum Ca2(+)-ATPase of the rat heart.
Authors: L MMaciel, RPolikar, DRohrer, B KPopovich, W HDillmann
Journal: Circulation Research (1990)

Age-associated slowing of cardiac relaxation related to the decline in the Ca2+ pump function of cardiac sarcoplasmic reticulum (SR) has been previously described. It is unclear if the decreased Ca2+ pump function results from a lower amount of Ca2(+)-ATPase protein or a decreased pumping activity of the enzyme. To determine if these alterations could be mediated by changes in the amount of the protein itself, the level of the messenger RNA (mRNA) coding for the Ca2(+)-ATPase of the SR of Fischer rat hearts (4- and 30-month-old rats) were quantitated with a Northern blotting technique. We observed that the levels of SR Ca2(+)-ATPase mRNA were 60% lower in old rats as compared with young rats, suggesting that a quantitative reduction in the levels of the corresponding protein could occur during aging to explain the delayed diastolic relaxation documented in old animals as opposed to a change in the specific activity of this enzyme. The thyroid hormone responsiveness of SR Ca2(+)-ATPase mRNA has been previo...
Abstract 15365: Effect of Guideline-Directed Medical Therapy on Central Aortic Pressure Waveforms in Patients With Heart Failure With Reduced Ejection Fraction
Authors: Alanna A Morris, Christopher Chen, Eisha Udeshi, Javed Butler, Arshed Quyyumi
Journal: Circulation (2018)

Introduction: Central arterial stiffness and wave reflections are important determinants of left ventricular afterload. Given the adverse effect of wave reflections on ventricular-vascular coupling...
Endomyocardial disease and eosinophilia. Report of a case.
Authors: B EJaski, E JGoetzl, J WSaid, M CFishbein
Journal: Circulation (1978)

While an association between blood eosinophilia and endomyocardial disease has been recognized, the role of the eosinophil in the pathogenesis of the cardiac lesions remains uncertain. In a 69-year-old-man with large cell carcinoma of the lung, marked eosinophilia was stimulated by and progressed with the course of the neoplasm which was producing an eosinophil chemotactic factor. Peripheral blood eosinophils were vacuolated and degranulated while those in the bone marrow were morphologically normal. Clinical evidence of cardiac dysfunction developed one month prior to death. At autopsy, 12 months after the onset of symptoms, endomyocardial disease was present. There were numerous eosinophils in the damaged myocardium and surrounding the pulmonary neoplasm. In patients with endomyocardial disease and eosinophilia, the eosinophil may be directly cardiotoxic or a primary mediator of cardiac damage; therapeutic attempts to reduce the number of eosinophils might be benefit.
Review Body's Report: Hospital Medical Staff
Authors: R. B. Bradshaw, C. J. Carr, L. E. S. Carrie, V. Cope, B. J. Cuddigan, J. E. Delahunty, D. M. Essenhigh, A. Fisher, D. L. Froggatt, M. W. L. Gear, J. I. H. Hadfield, J. R. Hampton, J. M. Holt, M. R. Lee, G. Maddox, G. R. Massarella, G. D. Middleton, T. R. Preston, B. J. Prout, J. L. Pugh, M. A. Pugh, T. G. Ramsell, J. A. Roth, S. K. Weeks, R. Whitehead
Journal: BMJ (1966)

SIR,-While not disputing that all doctors deserve an increase in their remuneration, it is surely quite incredible that a senior regis- trar and consultant, after many years of highly competitive and specialized training involving great personal sacrifice in time and money, and of family and home, constantly on the move and without any security what- ever, should now reap an ultimate reward less than that of the family doctor.This surely is the ultimate negation of personal effort to achieve a specialist position, and the opposite of any premise in industry, com- merce, or any other profession.That a one- year house-surgeon can now go into general practice and earn more than his own hospital chief, a man who took about 15 years to reach this position, must surely mean by even the simplest logic that the death knell of future hospital services has been sounded loud and clear.-Iam, etc., London N. 10.
2P Role of neutrophil-to-lymphocyte ratio (NLR) in the outcome of NSCLC EGFR mutated
Authors: S. Tolu, G. Saba, V. Impera, D. Spanu, N. Liscia, G. Pinna, A. Pireddu, L. Demurtas, E. Lai, F. Manca, C. Madeddu, E. Massa, G. Astara, M. Scartozzi
Journal: Journal of Thoracic Oncology (2021)
Cross-sectional echocardiographic examination of the interatrial septum.
Authors: J CDillon, A EWeyman, HFeigenbaum, R CEggleton, KJohnston
Journal: Circulation (1977)

The interatrial septum has not been readily appreciated by M-mode echocardiography. Cross-sectional echocardiography has the capability of recording the shape and location of the interatrial septum. Real-time cross-sectional echograms using a mechanically oscillating transducer were obtained on 100 consecutive patients. Echocardiographic examination of the left atrium and aorta was obtained in a plane perpendicular to the long axis of the atria. In 15 normal patients and 17 patients with atrial septal defects (ASD) and 51 patients with other forms of heart disease, the interatrial septum was recorded as a linear echo from the aorta to the posterior wall of the left atrium. In six patients who had ostium primum ASDs, the echoes from the interatrial septum disappeared near its expected junction with the interventricular septum. Drop out of echoes in the mid portion of the septum was noted in those patients who had ostium secundum atrial septal defects but this could not be differentiated from normal. These ...
Coronary angioplasty. Statewide experience in California.
Authors: J LRitchie, K APhillips, H SLuft
Journal: Circulation (1993)

BACKGROUNDThis report describes the in-hospital experience with percutaneous transluminal coronary angioplasty (PTCA) for the state of California in 1989. Data are derived from the statewide hospital discharge abstracts.METHODS AND RESULTSA total of 24,883 PTCAs were performed; most patients (70%) were men and most procedures were single vessel (87%). About one fifth (19%) of patients had a principal diagnosis of acute myocardial infarction (AMI). Overall mortality was 1.4% and was higher in the AMI group (4.2%) versus the non-AMI group (0.8%, P = .0001). Mortality was higher for AMI patients having PTCA on the day of or day after admission (5.5%) versus those treated later (2.6%, P = .0001). Five percent of patients had coronary artery bypass surgery (CABG) after PTCA; CABG was performed on the same day as PTCA in 61.7% of cases. Patients presenting with AMI were more likely to have CABG (7.1%) than non-AMI patients (4.5%, P = .0001). Mortality associated with CABG was 7.3% and was higher in the AMI grou...
Eicosanoids and control of mesangial cell contraction.
Authors: PMené, M JDunn
Journal: Circulation Research (1988)

Contraction of glomerular mesangial cells is stimulated in vitro by the vasoconstrictor metabolite of arachidonic acid, thromboxane A2. To establish the role of mesangial prostaglandin (PG) synthesis in the modulation of contractile responses, we studied the effects of the stable thromboxane A2/endoperoxide analogue U-46619 on cultured rat mesangial cells preincubated with 1) four structurally unrelated, nonsteroidal anti-inflammatory drugs, indomethacin, acetylsalicylic acid, meclofenamate, and piroxicam, to inhibit the synthesis of PGE2, the major mesangial metabolite of arachidonic acid; 2) exogenous PGE2 and the stable analogue of PGI2, iloprost; and 3) indomethacin in the presence of exogenous PGE2. Computer-assisted image analysis microscopy demonstrated enhancement of spontaneous and agonist-induced contraction by nonsteroidal anti-inflammatory drugs in individual cells grown on a glass substrate, from 37.2 +/- 7.3% to a maximum of 75.5 +/- 6.4% of the cells with piroxicam, at 1 microM U-46619. PGE...
ST-segment elevation with elective DC cardioversion.
Authors: P KChun, J EDavia, D JDonohue
Journal: Circulation (1981)

Elective direct-current cardioversion was performed in three patients with atrial fibrillation. Transient ST-segment elevation on monitored leads, lasting seconds, was recorded after cardioversion in all three patients. LDH, CPK isoenzymes, and myocardial scintigraphy did not reveal myocardial damage. Elective cardioversion should be performed with caution, for the potential for cardiac damage cannot be ignored.
Effects of proton buffering and of amiloride derivatives on reperfusion arrhythmias in isolated rat hearts. Possible evidence for an arrhythmogenic role of Na(+)-H+ exchange.
Authors: S CDennis, W ACoetzee, E JCragoe, L HOpie
Journal: Circulation Research (1990)

We investigated the hypothesis that an accelerated Na+o-H+i exchange on reperfusion may lead to a displacement of the 3[Na+] [Ca2+]i/o equilibrium in favor of an arrhythmogenic rise in cytosolic [Ca2+]. Supporting evidence was obtained by subjection of isolated rat hearts to 15 minutes of low-flow (5% of control) ischemia and 2 minutes of reperfusion in the presence of a Krebs-Henseleit HEPES buffer (pH 7.4) containing lactate (10 mM). At first, the [HEPES] was fixed at 5 mM; then, 2 minutes before reflow, either the [HEPES] was varied from 50 to 1 mM to slow H+o washout, or increasing concentrations of 5-(N,N-dimethyl)-amiloride (Ki 7 microM) or 5-(N,N-hexamethylene)-amiloride (Ki 0.2 microM) were added for inhibition of Na(+)-H+ exchange. In each case, reperfusion ventricular arrhythmias were reduced by 69-73% (p less than 0.001).
Objective and subjective analysis of left ventricular angiograms.
Authors: B RChaitman, HDeMots, J DBristow, JRösch, S HRahimtoola
Journal: Circulation (1975)

In order to determine the reproducibility of analyses of left ventriculograms, 35 cineangiograms were evaluated by four observers, two using standard quantitative techniques to determine ventricular volumes and a newly devised quantitative system to evaluate wall motion and two others using only visual inspection of the angiograms. Objective analysis repeated by the same observer correlated well for end-diastolic and end-systolic volumes and ejection fraction (r = .98, .99, respectively) and only one of 105 (1%) wall segments were identified differently. Variability in assessments increased when comparisons were made with a second objective observer. Correlation coefficients for the three volumetric parameters were .93, .98, and .95 and there was disagreement in the assessment of 8% of wall segments. Wide variability was present between an objective and two subjective observers in analyses of end-diastolic volumes (r = .63, .64). Regional wall motion was assessed differently in 19% and 27% of segments, re...
Erythropoietin Suppresses the Formation of Macrophage Foam Cells
Authors: Kuo-YunLu, Li-ChiehChing, Kuo-HuiSu, Yuan-BinYu, Yu RuKou, Sheng-HuangHsiao, Yu-ChuHuang, Chien-YuChen, Li-ChingCheng, Ching-ChianPan, Tzong-ShyuanLee
Journal: Circulation (2010)

Background— In addition to the hematopoietic effect of erythropoietin, increasing evidence suggests that erythropoietin also exerts protective effects for cardiovascular diseases. However, the role of erythropoietin and its underlying mechanism in macrophage foam cell formation are poorly understood. Methods and Results— Compared with wild-type specimens, erythropoietin was increased in atherosclerotic aortas of apolipoprotein E–deficient (apoE−/−) mice, mainly in the macrophage foam cells of the lesions. Erythropoietin levels in culture medium and macrophages were significantly elevated in response to oxidized low-density lipoprotein in a dose-dependent manner. Furthermore, erythropoietin markedly attenuated lipid accumulation in oxidized low-density lipoprotein–treated macrophages, a result that was due to an increase in cholesterol efflux. Erythropoietin treatment significantly increased ATP-binding cassette transporters (ABC) A1 and ABCG1 mRNA and protein levels without affecting protein expression of...
Localization and mechanism of ventricular tachycardia by ice mapping 1 week after the onset of myocardial infarction in dogs.
Authors: L JGessman, J BAgarwal, TEndo, R HHelfant
Journal: Circulation (1983)

We developed a new technique of   to localize the site of termination of ventricular tachycardia in dogs 4 to 8 days after the onset of myocardial infarction. During programmed stimulation-induced ventricular tachycardia, the epicardium was mapped by moving an ice probe with a 1 cm tip over the infarct, lateral border, and normal areas. In 31 of 46 morphologically distinct sustained ventricular tachycardias, a specific area could be found that reproducibly terminated ventricular tachycardia. During ventricular tachycardia, bridging or late diastolic electrical activity was recorded from ice termination sites. In vitro microelectrode studies of 10 ice termination sites revealed slow conduction, but no spontaneous or triggered automaticity or delayed afterdepolarizations. Conduction slowed to complete block when the Tyrode perfusate was cooled from 37 degrees to 27 degrees C. We conclude that ice mapping can physiologically localize a site responsible for maintenance of ventricular tachycardia b...