tbuckley/cabot-search huggingface dataset:
NEW AND NONOFFICIAL REMEDIES
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Short stature.
Authors: J M Parkin
Journal: BMJ (1976)

Short stature may be a sign of treatable disease and a cause of distress by itself.Assessment is essential as early as possible in childhood for two reasons: firstly, treatment, if appropriate, is effective only if started well before the epiphyses fuse; and, secondly, when no specific treatment is available, an informed prognosis at an early stage may allay anxiety and enable advice and support to be given to the child.
Efficacy of first-line combination therapy in metastatic renal cell carcinoma (mRCC) patients (pts) with poor performance status (PS).
Authors: Lucia Carril, Emeline Colomba, Carmen Romero-Ferreiro, Luigi Cerbone, Raffaele Ratta, Philippe Barthélémy, Clarisse Vindry, Francois Cherifi, Elouen Boughalem, Claude Linassier, Giuseppe Fornarini, Marine Gross-Goupil, Carolina Saldana, Maria Cruz Martin Soberón, Guillermo de Velasco, Cristina Pernaut, Carolina Alves Costa Silva, Ronan Flippot, Bernard Escudier, Laurence Albiges
Journal: Journal of Clinical Oncology (2022)

320 Background: Immune checkpoint combination therapy (ICI-combo) is the new standard of care for mRCC in first-line setting. However, pts with poor PS (≥2) were excluded from pivotal trials. Hence, the activity and safety of ICI-combo in this group of pts is still unknown. Methods: We performed a multicentre retrospective study of PS≥2 mRCC pts who received ICI-combo, either nivolumab-ipilimumab (NI) or pembrolizumab-axitinib (PA) as first-line treatment between 2017-2021. Patient’s characteristics, clinical outcomes and toxicity were retrospectively reviewed. We analysed overall response rate (ORR), disease control rate (DCR), progression-free survival (PFS), overall survival (OS) and grade ≥3 treatment-related adverse events (G≥3 AEs) in pts treated with NI or PA. The association between LIPI (Lung Immune Prognostic Index) and ORR, PFS and OS was also evaluated. Results: We identified 56 mRCC pts with PS≥2 treated with ICI-combo across 13 institutions. Thirty-six and 20 pts were treated with NI and PA respectively. Median age at diagnosis was 64 (31-83) years, 38 (68%) were male, 16 (29%) had prior nephrectomy and 40 (71%) had synchronous metastatic disease at diagnosis. Respectively, 19 (34%) and 37 (66%) pts were intermediate and poor risk according to IMDC. Fifty pts (89%) were clear cell RCC, and only 4 pts had sarcomatoid features reported. At the time of analysis (median follow-up 11.1 months(mo)) 45% pts were dead. The ORR for the entire cohort was 27%; ORR was numerically higher with PA (42%) than with NI (20%) but did not reach statistical significancy (p=0.157). Median PFS (mPFS) and mOS in the entire cohort were 4.4 mo and 15.9 mo respectively. No significant differences in PFS, OS or the rate of G≥3AEs were seen between the NI and PA groups. Efficacy and toxicity outcomes are described in the table below. No significant differences in OS or PFS according to the IMDC risk score were observed (p=0.818). However, LIPI was significantly associated with OS (poor LIPI: HR=8.18; p=0.004) and PFS (Intermediate LIPI: HR=2.4; p=0.048 and poor LIPI: HR=8.59; p&lt;0.001). LIPI was predictive of response in patients treated with NI (p=0.024). Conclusions: We report the first cohort of PS≥2 mRCC pts treated with ICI-combo in first-line setting. No significant differences in ORR, PFS or OS were seen between NI and PA. LIPI was significantly associated with both OS and PFS, and was predictive of ORR in the NI group. Prospective real-world studies are needed to confirm these results.[Table: see text]
Ambulance
Authors: Jack Coulehan
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A new star: how brightly will it shine
Authors: Z. Danilevicius
Journal: JAMA (1977)

European pharmacologists have proved that the type 2, or H<sub>2</sub>, histamine receptor blockers are powerful suppressors of hydrochloric acid secretion. Most of these drugs provide excellent symptomatic and therapeutic means to relieve the pain and to speed the healing of gastric and duodenal ulcers. However, drugs such as burimamide and metiamide, although effective, were found to be bone marrow toxic. Cimetidine is a new drug in this group that was recently introduced into clinical use in Great Britain. It seems to be effective and safe and has not shown serious side effects or dangerous adverse reactions. Cimetidine has been well investigated in the laboratory and by immunologic and direct clinical studies. At the Tenth Scandinavian Conference on Gastroenterology in September 1976, Bodemar and Walan<sup>1</sup>reported that during the first week of treatment with cimetidine, there was a statistically significant decrease of diurnal HCl production in patients receiving cimetidine
Editorial
Journal: Annals of the Rheumatic Diseases (1950)

a member of the Editorial Committee of this Journal, and has for many years actively advised the editors in the selection of material for publica- tion, and in matters of general policy.He is also an honorary member and past Medallist of the Heberden Society, which he addressed in October on his work on the role of Cortisone and ACTH in the field of the rheumatic diseases.A brief abstract of this lecture will be found later in this number.In May the Heberden Society met in Paris jointly with the Ligue Fran9aise contre le Rhumatisme.As this was the first time that a joint meeting of this sort had been held, it was decided by the editors that on this occasion two of the French papers should be printed in the language in which they were delivered.Readers are invited to comment upon this innovation, which it is not, however, proposed to repeat save in exceptional circumstances of this nature.We are asked by the Ligue Europeenne contre le Rhumatisme
Respiratory syncytial virus infection: admissions to hospital in industrial, urban, and rural areas. Report to the Medical Research Council Subcommittee on Respiratory Syncytial Virus Vaccines.
Journal: BMJ (1978)

A collaborative study of 10 centres during the winters of 1973-4 and 1974-5 showed that respiratory syncytial virus (RSV) was the major cause of admission to hospital for respiratory disease in children under 5 years of age in industrial, urban, and rural communities. In all areas the distribution of clinical symptoms and their severity was similar, but the rate of admission in relation to population was over twice as high in industrial as in other areas. The maximum yearly admission rate occurred among infants aged 1 to 3 months: 24.5 per 1000 of that age group were admitted to hospital. Two methods of diagnosing RSV infection--virus isolation and immunofluorescence from postnasal aspirates--were compared, and the two methods were found to agree in 91% of cases. The results of this study confirmed the importance of RSV as a respiratory pathogen in young children. Further studies are needed to determine how the virus produces its effects and to develop preventive measures.
Predictors of Left Main Coronary Artery Disease in the ISCHEMIA Trial
Authors: Roxy Senior, Harmony R Reynolds, James K Min, Daniel S Berman, Michael H Picard, Bernard R Chaitman, Leslee J Shaw, Courtney B Page, Sajeev C Govindan, Jose Lopez-Sendon, Jesus Peteiro, Gurpreet S Wander, Jaroslaw Drozdz, Jose Marin-Neto, Joseph B Selvanayagam, Jonathan D Newman, Christophe Thuaire, Johann Christopher, James J Jang, Raymond Y Kwong, Sripal Bangalore, Gregg W Stone, Sean M O'Brien, William E Boden, David J Maron, Judith S Hochman
Journal: Journal of the American College of Cardiology (2022)
Histamine
Authors: J. H. Gaddum
Journal: BMJ (1948)

A special lecture given at the University of London on Feb. 20. shock was always due to the release of histamine, but they were certainly wrong; there are many kinds of shock.When histamine is injected subcutaneously, so that it is slowly absorbed, the mucous membrane of the stomach secretes large quantities of acid juice poor in enzymes.The use of this fact as a test of gastric function is the main clinical application of histamine.Histamine also stimulates the lacrimal glands, the salivary glands, the pancreas, and the glands of the intestine, but not the sweat glands.NH H CH C-N1 CH2 HNOC CH Nil> HISTIDINE CH CH CIA~I
DIETARY FRUCTANS
Authors: M. B. Roberfroid, N. M. Delzenne
Journal: Annual Review of Nutrition (1998)

▪ Abstract Fructan is a general term used for any carbohydrate in which one or more fructosyl-fructose link constitutes the majority of osidic bonds. This review focuses on the fate of inulin-type fructans (namely native chicory inulin, oligofructose produced by the partial enzymatic hydrolysis of chicory inulin, and synthetic fructans produced by enzymatic synthesis from sucrose) in the gastrointestinal tract, as well as on their systemic physiological effects on mineral absorption, carbohydrate and lipid metabolism, hormone balance, and nitrogen homeostasis. The scientific evidence for the functional claims of inulin-type fructans is discussed, as well as their potential application in risk reduction of disease, namely constipation, infectious diarrhea, cancer, osteoporosis, atherosclerotic cardiovascular disease, obesity, and non-insulin dependent diabetes.
Endocrine myopathies.
Authors: P Kendall-Taylor, D M Turnbull
Journal: BMJ (1983)

Mirror-image allodynia is a mysterious phenomenon that occurs in association with many clinical pain syndromes. Allodynia refers to pain in response to light touch/pressure stimuli, which normally are perceived as innocuous. Mirror-image allodynia arises from the healthy body region contralateral to the actual site of trauma/inflammation. Virtually nothing is known about the mechanisms underlying such pain. A recently developed animal model of inflammatory neuropathy reliably produces mirror-image allodynia, thus allowing this pain phenomenon to be analyzed. In this sciatic inflammatory neuropathy (SIN) model, decreased response threshold to tactile stimuli (mechanical allodynia) develops in rats after microinjection of immune activators around one healthy sciatic nerve at mid-thigh level. Low level immune activation produces unilateral allodynia ipsilateral to the site of sciatic inflammation; more intense immune activation produces bilateral (ipsilateral + mirror image) allodynia. The present studies demonstrate that both ipsilateral and mirror-image SIN-induced allodynias are (1) reversed by intrathecal (peri-spinal) delivery of fluorocitrate, a glial metabolic inhibitor; (2) prevented and reversed by intrathecal CNI-1493, an inhibitor of p38 mitogen-activated kinases implicated in proinflammatory cytokine production and signaling; and (3) prevented or reversed by intrathecal proinflammatory cytokine antagonists specific for interleukin-1, tumor necrosis factor, or interleukin-6. Reversal of ipsilateral and mirror-image allodynias was rapid and complete even when SIN was maintained constantly for 2 weeks before proinflammatory cytokine antagonist administration. These results provide the first evidence that ipsilateral and mirror-image inflammatory neuropathy pain are created both acutely and chronically through glial and proinflammatory cytokine actions.
Impact of Autophagy on Prognosis of Patients With Dilated Cardiomyopathy
Authors: Hiromitsu Kanamori, Akihiro Yoshida, Genki Naruse, Susumu Endo, Shingo Minatoguchi, Takatomo Watanabe, Tomonori Kawaguchi, Toshiki Tanaka, Yoshihisa Yamada, Nobuhiro Takasugi, Takuma Ishihara, Atsushi Mikami, Nagisa Miyazaki, Kazuhiko Nishigaki, Shinya Minatoguchi, Tatsuhiko Miyazaki, Hiroyuki Okura
Journal: Journal of the American College of Cardiology (2022)
Oncolytic adenovirus decreases the proportion of TIM-3<sup>+</sup> subset of tumor-infiltrating CD8<sup>+</sup> T cells with correlation to improved survival in patients with cancer
Authors: Ilkka Liikanen, Saru Basnet, Dafne C A Quixabeira, Kristian Taipale, Otto Hemminki, Minna Oksanen, Matti Kankainen, Juuso Juhila, Anna Kanerva, Timo Joensuu, Siri Tähtinen, Akseli Hemminki
Journal: Journal for ImmunoTherapy of Cancer (2022)

Oncolytic viruses are a potent form of active immunotherapy, capable of invoking antitumor T-cell responses. Meanwhile, less is known about their effects on immune checkpoints, the main targets for passive immunotherapy of cancer. T-cell immunoglobulin and mucin domain-3 (TIM-3) is a coinhibitory checkpoint driving T-cell exhaustion in cancer. Here we investigated the effects of oncolytic adenovirus on the TIM-3 checkpoint on tumor-infiltrating immune cells and clinical impact in patients with cancer receiving oncolytic immunotherapy.Modulation of TIM-3 expression on tumor-infiltrating immune cells was studied preclinically in B16 melanoma following intratumoral treatment with Ad5/3∆24-granulocyte-macrophage colony-stimulating factor oncolytic adenovirus. We conducted a retrospective longitudinal analysis of 15 patients with advanced-stage cancer with tumor-site biopsies before and after oncolytic immunotherapy, treated in the Advanced Therapy Access Program (ISRCTN10141600, April 5, 2011). Following patient stratification with regard to TIM-3 (increase vs decrease in tumors), overall survival and imaging/marker responses were evaluated by log-rank and Fisher's test, while coinhibitory receptors/ligands, transcriptomic changes and tumor-reactive and tumor-infltrating immune cells in biopsies and blood samples were studied by microarray rank-based statistics and immunoassays.Preclinically, TIM-3+ tumor-infiltrating lymphocytes (TILs) in B16 melanoma showed an exhausted phenotype, whereas oncolytic adenovirus treatment significantly reduced the proportion of TIM-3+ TIL subset through recruitment of less-exhausted CD8+ TIL. Decrease of TIM-3 was observed in 60% of patients, which was associated with improved overall survival over TIM-3 increase patients (p=0.004), together with evidence of clinical benefit by imaging and blood analyses. Coinhibitory T-cell receptors and ligands were consistently associated with TIM-3 changes in gene expression data, while core transcriptional exhaustion programs and T-cell dysfunction were enriched in patients with TIM-3 increase, thus identifying patients potentially benefiting from checkpoint blockade. In striking contrast, patients with TIM-3 decrease displayed an acute inflammatory signature, redistribution of tumor-reactive CD8+ lymphocytes and higher influx of CD8+ TIL into tumors, which were associated with the longest overall survival, suggesting benefit from active immunotherapy.Our results indicate a key role for the TIM-3 immune checkpoint in oncolytic adenoviral immunotherapy. Moreover, our results identify TIM-3 as a potential biomarker for oncolytic adenoviruses and create rationale for combination with passive immunotherapy for a subset of patients.
The NFL's drug testing policy
Authors: R. Baskin
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Unusual Electrocardiographic Findings in an Elderly Patient With Syncope
Authors: Yubin Zhang, Tong Liu, Gan-Xin Yan
Journal: JAMA Internal Medicine (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
DDIS-24. PROTEASOME INHIBITION IS A TARGETED THERAPY FOR PTEN-DEFICIENT GLIOBLASTOMAS
Authors: Jorge Benitez, Darren Finlay, Jianhui Ma, Tomoyuki Koga, Kristiina Vuori, Frank Furnari
Journal: Neuro-Oncology (2018)

One of the most common genetic alterations in glioblastoma (30–40%) occurs in the PTEN (phosphatase and tensin homolog) tumor suppressor gene, where loss of function has been mechanistically linked to increased tumor cell invasion, and to a lack of radio- and chemo-therapy response. To identify new drug compounds that target PTEN-deficient brain tumors we performed a high throughput drug screen using patient-derived GBM spheres and found that PTEN-deficient samples were highly sensitive to proteasome inhibition. We confirmed this sensitivity in GBM spheres and iNPCs (inducible Neuronal Progenitor Cells) by genetically over-expressing or deleting PTEN, where PTEN over-expression decreased and PTEN-deletion increased sensitivity to the drug, respectively. Additionally, proteasome inhibition specifically suppressed tumor growth in mice of orthotopically engrafted human glioblastoma samples. Mechanistically, we determined that PTEN-deficient cells are more sensitive to proteasome inhibition due to an increase in protein synthesis rate and loss of autophagy activity associated with activation of the PI3K/mTOR pathway. This study reveals that proteasome inhibition is a targeted-therapeutic strategy for PTEN-deficient brain cancer.
Erratum: “Measurement of Novel, Drinking Water-Associated PFAS in Blood from Adults and Children in Wilmington, North Carolina”
Authors: Nadine Kotlarz, James McCord, David Collier, C. Suzanne Lea, Mark Strynar, Andrew B. Lindstrom, Adrien A. Wilkie, Jessica Y. Islam, Katelyn Matney, Phillip Tarte, M.E. Polera, Kemp Burdette, Jamie DeWitt, Katlyn May, Robert C. Smart, Detlef R.U. Knappe, Jane A. Hoppin
Journal: Environmental Health Perspectives (2020)
Enuresis.
Authors: G V Lewis
Journal: BMJ (1979)

family, with the additional problems at home arising from the excessive washing involved.It is no comfort to child or parent to be told, "He will grow out of it."We feel, then, that it is unfair to dismiss a potentially useful treatment so sweepingly.Surely it would be more sensible for us to aim to educate parents to treat the drugs with caution, and to make more use of childproof containers both for syrup and for tablets.
Mortality among young black women using contraceptives
Authors: H. W. Ory
Journal: JAMA (1984)

Data on the risk of death associated with various contraceptive methods are incomplete. Therefore, we analyzed the mortality rates for young, black inner-city women who used one of four methods of contraception—oral contraceptives, depomedroxyprogesterone acetate, intrauterine (contraceptive) devices, and barrier methods. The subjects were 30,580 15-to 44-year-old women who enrolled at a family planning clinic between 1967 and 1972 and who were observed by monitoring death certificates through the end of 1977. Forty percent of the 218 deaths observed were from accidents and violence. Use of this family planning clinic greatly reduced the risk of death from childbearing; only two deaths were associated with pregnancy and childbirth, compared with the 24 deaths expected. Overall, users of the four methods died at similar, low rates. Given that this study involves considerable loss to follow-up, possible acute effects of contraceptives (eg, infections or thrombosis) are more accurately estimated than possible long-term effects (eg, cancer). (<i>JAMA</i>1984;251:1044-1048)
The Primate Premotor Cortex: Past, Present, and Preparatory
Authors: S. Wise
Journal: Annual Review of Neuroscience (1985)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More