tbuckley/cabot-search huggingface dataset:
Music's putative adaptive function hinges on a combination of distinct mechanisms
Authors: Bruno Gingras
Journal: Behavioral and Brain Sciences (2021)

Abstract Music's efficacy as a credible signal and/or as a tool for social bonding piggybacks on a diverse set of biological and cognitive processes, implying different proximate mechanisms. It is likely this multiplicity of mechanisms that explains why it is so difficult to account for music's putative biological role(s), as well as its possible origins, by proposing a single adaptive function.
1503O Clinical and scientific impact of National Cancer Institute: Sponsored clinical trial network group treatment trials
Authors: J.M. Unger, M. LeBlanc, M. Bertagnolli, N. Wolmark, W.J. Curran, P.J. O'Dwyer, M.D. Schnall, R.S. Mannel, J.P. Costantino, R.J. Gray, F. Zhao, F. Hong, M. Bah, R. Vaidya, C.D. Blanke
Journal: Annals of Oncology (2021)
Abstract 16305: Validation of Complete Blood Count Datum as a Key Factor in Early Risk Stratification of Patients With ST-Elevation Myocardial Infarction
Authors: Kyung Hoon Cho, Myung Ho Jeong, Min Chul Kim, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Youngkeun Ahn
Journal: Circulation (2019)

Introduction: It is uncertain to what extent the complete blood count datum including neutrophil-to-lymphocyte ratio (NLR) and hemoglobin (Hb) levels, which is easily available in terms of time and...
Single-Cell RNA Sequencing Reveals Sexually Dimorphic Transcriptome and Type 2 Diabetes Genes in Mouse Islet β Cells
Authors: Gang Liu, Yana Li, Tengjiao Zhang, Mushan Li, Sheng Li, Qing He, Shuxin Liu, Minglu Xu, Tinghui Xiao, Zhen Shao, Weiyang Shi, Weida Li
Journal: Genomics Proteomics & Bioinformatics (2021)

Type 2 diabetes (T2D) is characterized by the malfunction of pancreatic β cells. Susceptibility and pathogenesis of T2D can be affected by multiple factors, including sex differences. However, the mechanisms underlying sex differences in T2D susceptibility and pathogenesis remain unclear. Using single-cell RNA sequencing (scRNA-seq), we demonstrate the presence of sexually dimorphic transcriptomes in mouse β cells. Using a high-fat diet-induced T2D mouse model, we identified sex-dependent T2D altered genes, suggesting sex-based differences in the pathological mechanisms of T2D. Furthermore, based on islet transplantation experiments, we found that compared to mice with sex-matched islet transplants, sex-mismatched islet transplants in healthy mice showed down-regulation of genes involved in the longevity regulating pathway of β cells. Moreover, the diabetic mice with sex-mismatched islet transplants showed impaired glucose tolerance. These data suggest sexual dimorphism in T2D pathogenicity, indicating that sex should be considered when treating T2D. We hope that our findings could provide new insights for the development of precision medicine in T2D.
1091TiP STARBOARD: Randomized phase III study of encorafenib (enco) + binimetinib (bini) + pembrolizumab (pembro) for first-line treatment of metastatic or unresectable locally advanced BRAF V600-mutant melanoma
Authors: D. Schadendorf, R. Dummer, C. Robert, A. Ribas, R.J. Sullivan, T. Panella, M.A. Mckean, E.S. Santos, K. Brill, A. Polli, A. di Pietro, P.A. Ascierto
Journal: Annals of Oncology (2021)
529P A phase Ib trial of belvarafenib in combination with cobimetinib in patients (pts) with RAS- or RAF- mutated (m) solid tumors: Updated safety data and indication-specific efficacy results
Authors: T.W. Kim, J. Lee, T.M. Kim, S.J. Shin, S-W. Han, J-S. Kim, Y.J. Kim, C. Yoo, Y.S. Hong, J.W. Kim, D.H. Lee, C.B. Ahn, S.T. Kim, J-W. Kim, Y-H. Hong, J. Kim, E. Baek, B. Choi, V. Malhi, S. Baek
Journal: Annals of Oncology (2021)
493P Impact of age on the activity of aflibercept plus FOLFIRI in metastatic colorectal cancer (mCRC): Real world data from the QoLiTrap study
Authors: J. Thaler, H. Kröning, M-O. Zahn, F. Scholten, H-G. Derigs, S. Pederiva, S. Anchisi, P. Bohanes, B. Grünberger, C. Windemuth-Kieselbach, G. Piringer, R. von Moos, R-D. Hofheinz
Journal: Annals of Oncology (2021)
Climate change and infectious disease in Europe: Impact, projection and adaptation
Authors: Jan C. Semenza, Shlomit Paz
Journal: The Lancet Regional Health - Europe (2021)

Europeans are not only exposed to direct effects from climate change, but also vulnerable to indirect effects from infectious disease, many of which are climate sensitive, which is of concern because of their epidemic potential. Climatic conditions have facilitated vector-borne disease outbreaks like chikungunya, dengue, and West Nile fever and have contributed to a geographic range expansion of tick vectors that transmit Lyme disease and tick-borne encephalitis. Extreme precipitation events have caused waterborne outbreaks and longer summer seasons have contributed to increases in foodborne diseases. Under the Green Deal, The European Union aims to support climate change health policy, in order to be better prepared for the next health security threat, particularly in the aftermath of the traumatic COVID-19 experience. To bolster this policy process we discuss climate change-related hazards, exposures and vulnerabilities to infectious disease and describe observed impacts, projected risks, with policy entry points for adaptation to reduce these risks or avoid them altogether.
1111P New prognostic frontiers for lung neuroendocrine tumors: An Italian-Spanish multicentric study of 200 cases
Authors: A. La Salvia, I. Persano, M. Verrico, M. Bassi, R. Modica, A. Audisio, G. Puliani, M. Rinzivillo, I. Zanata, R. Baldelli, P. Razzore, F. Panzuto, M. Volante, E. Giannetta, M. Appetecchia, M.C. Zatelli, A. Colao, M.P. Brizzi, R. Garcia-Carbonero, A. Faggiano
Journal: Annals of Oncology (2021)
LBA40 SECOMBIT: The best sequential approach with combo immunotherapy [ipilimumab (I) /nivolumab (N)] and combo target therapy [encorafenib (E)/binimetinib (B)] in patients with BRAF mutated metastatic melanoma: A phase II randomized study
Authors: P.A. Ascierto, M. Mandala, P.F. Ferrucci, P. Rutkowski, M. Guidoboni, A.M. Arance Fernandez, V. Ferraresi, E. Maiello, M. Guida, M. Del Vecchio, M.T. Fierro, P. Queirolo, C. Lebbe, H. Helgadottir, I. Melero, G. Palmieri, D. Giannarelli, A.M. Grimaldi, R. Dummer, V. Chiarion Sileni
Journal: Annals of Oncology (2021)
Eosinophilic Esophagitis
Authors: Amanda Muir, Gary W. Falk
Journal: JAMA (2021)

Eosinophilic esophagitis (EoE) is a chronic immune-mediated inflammatory disease of the esophagus that affects an estimated 34.4/100 000 people in Europe and North America. EoE affects both children and adults, and causes dysphagia, food impaction of the esophagus, and esophageal strictures.
1754P Current picture of Anaplastic Thyroid Cancer patients' care and meetable needs: A survey of 94 institutions from the EORTC Endocrine and Head and Neck Cancer Groups
Authors: L.D. Locati, E. Colombo, M. Dedecjus, C. de la Fouchardière, M. Bongiovanni, R. Netea-Maier
Journal: Annals of Oncology (2021)
ST-Segment Elevation in a Man Receiving Peritoneal Dialysis
Authors: Yi-Wei Cao, Lei Liang, Hao-Yu Wu
Journal: JAMA Internal Medicine (2021)

This case report examines echocardiogram findings in a man with a history of chronic kidney disease, peritoneal dialysis, and myocardial infarction who presented with heart palpitations and severe weakness of the upper and lower extremities.
437P Quality of life (QoL) in patients (pts) with microsatellite instability (MSI-H) or mismatch repair deficient (dMMR) metastatic colorectal cancer (mCRC) treated with nivolumab (NIVO) alone or in combination with ipilimumab (IPI): CheckMate 142
Authors: E. Van Cutsem, M. Dixon, F. Taylor, X. Sun, C. Yip, S.I. Blum
Journal: Annals of Oncology (2021)
Exposure to microgravity environment may induce genomic instability
Authors: Christina Pevey, Kate Kelly, K. Singh, J DuMond
Journal: Cancer Research (2008)

4313  Several pathophysiological changes associated with long-term space flight have been reported. Reduction in the DNA repair capacity resulting into genomic instability and its association with various human diseases has also been reported. The effect of simulated microgravity on the DNA damage resulting into genomic instability is not clear. The objective of this study was to test whether simulated microgravity conditions affects the expression of DNA repair genes. To achieve this objective the human T-lymphocyte cells were grown for 72 hours in a NASA-developed Rotating Wall Vessel (RWV) bioreactor that simulates a microgravity condition. In parallel, cells were also grown in normal gravity condition in culture flasks. The cells were harvested at a 72 hour time point and RNA was isolated. To examine the effect of microgravity on the expression of DNA repair genes, a real-time PCR based human DNA damage pathway focused gene array expression profiling was performed. The result of this study revealed more than 2-fold decreased expression of 6 genes (ATRX, GADD45G, IHPK3, RAD18, TP53, and XPC). The expressions of another 4 genes (DDIT3, MAPK12, NTHL1, and TP73) were more then 2-fold up regulated. Theses genes are crucial for the maintenance of genomic stability of the cells. Therefore, the finding of this study suggests that microgravity condition can induce alterations in the expression of these DNA repair genes. The alteration in DNA repair systems by microgravity condition may make the cells vulnerable to genomic instability and ultimately result in associated diseases.
Bioinspired membrane-based nanomodulators for immunotherapy of autoimmune and infectious diseases
Authors: Yesi Shi, Hongyan Qian, Peishi Rao, Dan Mu, Yuan Liu, Gang Liu, Zhongning Lin
Journal: Acta Pharmaceutica Sinica B (2021)

Autoimmune or infectious diseases often instigate the undesirable damages to tissues or organs to trigger immune-related diseases, which involve plenty of immune cells, pathogens and autoantibodies. Nanomedicine has a great potential in modulating immune system. Particularly, biomimetic nanomodulators can be designed for prevention, diagnosis and therapy to achieve a better targeted immunotherapy. With the development of materials science and bioengineering, a wide range of membrane-coated nanomodulators are available. Herein, we summarize recent advancements of bioinspired membrane-coated nanoplatform for systemic protection against immune-related diseases including autoimmune and infectious diseases. We also rethink the challenges or limitations in the progress of the therapeutic nanoplatform, and discuss the further application of the nanomodulators in the view of translational medicine for combating immune-related diseases.
Covid-19: Chikwe Ihekweazu: “It’s a rare privilege” to lead new pandemic hub
Authors: Gareth Iacobucci
Journal: BMJ (2021)

Gareth Iacobucci spoke to the head of the World Health Organization's new Hub for Pandemic and Epidemic Intelligence about his ambitions for the venture Was the world sufficiently prepared for covid-19? Whatever the answer to that question, WHO's new Hub for Pandemic and Epidemic Intelligence1 wants to ensure that lessons are learnt and acted on. It aims to facilitate greater sharing of better information, so that the global response to future health emergencies is smarter, quicker, and more effective (see box 1). Box 1 ### What WHO's new hub aims to provideRETURN TO TEXT The hub, based in Berlin and funded with an initial investment of $100m (£74m; €86m) from the German government, will be led by Chikwe Ihekweazu, an epidemiologist, director general of Nigeria's Centre for Disease Control since 2016, and WHO's new assistant director general of health emergency intelligence (see box 2). Box 2 ### Chikwe Ihekweazu: Career profileRETURN TO TEXT
443P EMERGE: A phase II trial assessing the efficacy of domatinostat plus avelumab in patients with previously treated advanced mismatch repair proficient oesophagogastric and colorectal cancers – phase IIA dose finding
Authors: E. Cartwright, F. Turkes, C. Saffery, A. Tran, G. Smith, S. Esteban Moreno, S. Hatt, A. Renn, E. Johnston, D. Kohoutova, R. Begum, E. Smyth, C. Peckitt, C. Fribbens, S. Rao, D. Watkins, I. Chau, N. Starling, D. Cunningham
Journal: Annals of Oncology (2021)
LBA63 Placebo-controlled, double-blinded phase Ⅲ study comparing dexamethasone on day 1 with dexamethasone on days 1 to 4, with combined neurokinin-1 receptor antagonist, palonosetron, and olanzapine in patients receiving cisplatin-containing highly emetogenic chemotherapy: SPARED trial
Authors: K. Shimomura, H. Minatogawa, T. Mashiko, H. Arioka, H. Iihara, M. Sugawara, N. Hida, K. Akiyama, S. Nawata, A. Tsuboya, K. Mishima, N. Izawa, T. Miyaji, K. Honda, Y. Inada, Y. Ohno, C. Katada, H. Morita, T. Yamaguchi, T.E. Nakajima
Journal: Annals of Oncology (2021)
380TiP A phase I/II dose-escalation and expansion cohort study of intracerebroventricular radioimmunotherapy using 177Lu-DTPA-omburtamab in pediatric and adolescent patients with recurrent or refractory medulloblastoma
Authors: S. Khatua, M. Düring, C.L. Lind, J.R. Nielsen
Journal: Annals of Oncology (2021)
1256P Capmatinib safety update in MET dysregulated NSCLC from the GEOMETRY mono-1 trial
Authors: R.S. Heist, E.B. Garon, H.J.M. Groen, D.S.W. Tan, O. Tanriverdi, A. Robeva, S. Le Mouhaer, M. Carbini, A. Chassot Agostinho, J. Wolf
Journal: Annals of Oncology (2021)
494P Early-onset colorectal cancer: 10-year cases documented in a comprehensive cancer centre illustrate the importance of a growing oncological problem
Authors: J.C.C. Ruffinelli, E. Guinó, N. Duenas Cid, M. Navarro, V. Moreno, J.M. Brunet Vidal, R. Salazar, C. Santos Vivas
Journal: Annals of Oncology (2021)
536P Incidence of fractures in TRK fusion cancer patients treated with larotrectinib
Authors: T.W. Laetsch, C.M. van Tilburg, S. Kummar, A. Dowlati, K. Guiver, M. Fellous, N. Brega, E. De La Cuesta, A. Shurshalina, A. Drilon, D. Hong
Journal: Annals of Oncology (2021)
Methylphenidate for Apathy in Alzheimer Disease—Why Should We Care?
Authors: Carolyn Fredericks
Journal: JAMA Neurology (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Do physical interventions improve outcomes following concussion: a systematic review and meta-analysis?
Authors: Susan A Reid, Joshua Farbenblum, Shreya McLeod
Journal: British Journal of Sports Medicine (2021)

Objective To investigate the effect of physical interventions (subthreshold aerobic exercise, cervical, vestibular and/or oculomotor therapies) on days to recovery and symptom scores in the management of concussion. Design A systematic review and meta-analysis. Data sources Medline, CINAHL, Embase, SportDiscus, Cochrane library, Scopus and PEDro. Eligibility criteria Randomised controlled trials of participants with concussion that evaluated the effect of subthreshold aerobic exercise, cervical, vestibular and/or oculomotor therapies on days to recovery/return to activity, symptom scores, balance, gait and/or exercise capacity. Results Twelve trials met the inclusion criteria: 7 on subthreshold aerobic exercise, 1 on vestibular therapy, 1 on cervical therapy and 3 on individually tailored multimodal interventions. The trials were of fair to excellent quality on the PEDro scale. Eight trials were included in the quantitative analysis. Subthreshold aerobic exercise had a significant small to moderate effect in improving symptom scores (standardised mean difference (SMD)=0.43, 95% CI 0.18 to 0.67, p=0.001, I 2 =0%) but not in reducing days to symptom recovery in both acutely concussed individuals and those with persistent symptoms (SMD=0.19, 95% CI −0.54 to 0.93, p=0.61, I 2 =52%). There was limited evidence for stand-alone cervical, vestibular and oculomotor therapies. Concussed individuals with persistent symptoms (&gt;2 weeks) were approximately 3 times more likely to have returned to sport by 8 weeks (relative risk=3.29, 95% CI 0.30 to 35.69, p=0.33, I 2 =83%) if they received individually tailored, presentation-specific multimodal interventions (cervical, vestibular and oculo-motor therapy). In addition, the multimodal interventions had a moderate effect in improving symptom scores (SMD=0.63, 95% CI 0.11 to 1.15, p=0.02, I 2 =0%) when compared with control. Conclusions Subthreshold aerobic exercise appears to lower symptom scores but not time to recovery in concussed individuals. Individually tailored multimodal interventions have a worthwhile effect in providing faster return to sport and clinical improvement, specifically in those with persistent symptoms. PROSPERO registration number CRD42020108117.
373P Brain metastases: Extracranial disease status as a prognostic factor after whole brain radiotherapy. Results from a prospective, population-based study
Authors: O.E. Yri, G.L. Astrup, M.J. Hjermstad, N.K. Aass, J-Å. Lund, R. van Helvoirt, Ø. Paulsen, S. Kaasa
Journal: Annals of Oncology (2021)
Versatile metal-phenolic network nanoparticles for multitargeted combination therapy and magnetic resonance tracing in glioblastoma
Authors: Yulin Zhang, Kaiyan Xi, Xiao Fu, Haifeng Sun, Hong Wang, Dexin Yu, Zhiwei Li, Yuan Ma, Xinjie Liu, Bin Huang, Jian Wang, Gang Li, Jiwei Cui, Xingang Li, Shilei Ni
Journal: Biomaterials (2021)

Glioblastoma multiforme (GBM) is a common malignancy of the central nervous system, but conventional treatments yield unsatisfactory results. Although innovative therapeutic approaches have been developed, they prolong survival by only approximately 5 months. The heterogeneity of GBM renders growth inhibition with a single drug difficult, and exploring combination approaches with multiple targets for the comprehensive treatment of GBM is expected to overcome this limitation. In this study, we designed a biocompatible cRGD/Pt + DOX@GFNPs (RPDGs) nanoformulation to disrupt redox homeostasis in GBM cells and promote the simultaneous occurrence of efficient apoptosis and ferroptosis. Taking advantage of the highly stable Fenton reaction catalytic activity of gallic acid (GA)/Fe2+ nanoparticles in physiological environments, the ability of Pt (IV) to deplete glutathione (GSH) and increase reactive oxygen species (ROS) levels, and the efficient photothermal conversion efficiency of GA/Fe2+ nanoparticles, our synthesized multifunctional and multitargeted RPDGs significantly increased intracellular ROS levels and thus induced ferroptosis. Furthermore, the RPDGs displayed superior photothermal responsiveness and magnetic resonance imaging (MRI) capabilities. These results indicate that RPDGs can not only directly inhibit the growth of tumors but also effectively improve the efficient translocation of conventional chemotherapeutic drugs across the blood-brain barrier, thereby providing a new approach for the comprehensive treatment of GBM.
オリゴ転移性疾患の特性化と分類:癌コンセンサス推奨の研究と治療のための放射線療法と腫瘍学およびヨーロッパ組織のためのヨーロッパ社会【JST・京大機械翻訳】
Authors: Guckenberger Matthias, Lievens Yolande, Bouma Angelique B, Collette Laurence, Dekker Andre, deSouza Nandita M, Dingemans Anne-Marie C, Fournier Beatrice, Hurkmans Coen, Lecouvet Frederic E, Meattini Icro, Romero Alejandra Mendez, Ricardi Umberto, Russell Nicola S, Schanne Daniel H, Scorsetti Marta, Tombal Bertrand, Verellen Dirk, Verfaillie Christine, Ost Piet
Journal: The Lancet Oncology (2020)
1634P Communication specifics with cancer patients during the COVID-19 pandemic in Croatia: Can a virtual visit meet the needs of cancer patients?
Authors: R. Kelemenic-Drazin, N. Svilicic, A. Budisavljevic, N. Dedic Plavetic, I. Kardum Fucak, T. Silovski, V. Telesmanic Dobric, M. Nalbani, Z. Curic, Z. Boric-Mikez, T. Ladenhauser, D. Trivanovic, Z. Vojnovic, I. Tomas, S. Plestina
Journal: Annals of Oncology (2021)
1230P Elderly patients treated with afatinib in clinical practice: Final results of the GIDEON study in EGFR mutated NSCLC in Germany
Authors: W.M. Brueckl, M. Reck, J. Rawluk, H. Schaefer, K. Neben, M. Moeller, S. Krueger, K. Kokowski, J.H. Ficker, A. Schueler, E. Laack
Journal: Annals of Oncology (2021)
Neoadjuvant talimogene laherparepvec plus surgery versus surgery alone for resectable stage IIIB–IVM1a melanoma: a randomized, open-label, phase 2 trial
Authors: R. Dummer, D. E. Gyorki, J. Hyngstrom, A. C. Berger, R. Conry, L. Demidov, A. Sharma, S. A. Treichel, H. Radcliffe, K. S. Gorski, A. Anderson, E. Chan, M. Faries, M. I. Ross
Journal: Nature Medicine (2021)
1142P Improved duplex sequencing-based method suitable for detection of hypermutator phenotype in FFPE-derived tumor samples
Authors: N.V. Mitiushkina, G.A. Yanus, T.A. Laidus, I.V. Bizin, A.O. Ivantsov, E.N. Imyanitov
Journal: Annals of Oncology (2021)
Activation of the Hypoxia-Inducible Factor Pathway Inhibits Epithelial Sodium Channel–Mediated Sodium Transport in Collecting Duct Principal Cells
Authors: Eva Dizin, Valérie Olivier, Isabelle Roth, Ali Sassi, Grégoire Arnoux, Suresh Ramakrishnan, Sandrine Morel, Brenda R. Kwak, Johannes Loffing, Edith Hummler, Roland H. Wenger, Ian J. Frew, Eric Feraille
Journal: Journal of the American Society of Nephrology (2021)

Active sodium reabsorption is the major factor influencing renal oxygen consumption and production of reactive oxygen species (ROS). Increased sodium reabsorption uses more oxygen, which may worsen medullary hypoxia and produce more ROS via enhanced mitochondrial ATP synthesis. Both mechanisms may activate the hypoxia-inducible factor (HIF) pathway. Because the collecting duct is exposed to low oxygen pressure and variations of active sodium transport, we assessed whether the HIF pathway controls epithelial sodium channel (ENaC)-dependent sodium transport.We investigated HIF's effect on ENaC expression in mpkCCD cl4 cells (a model of collecting duct principal cells) using real-time PCR and western blot and ENaC activity by measuring amiloride-sensitive current. We also assessed the effect of hypoxia and sodium intake on abundance of kidney sodium transporters in wild-type and inducible kidney tubule-specific Hif1α knockout mice.In cultured cells, activation of the HIF pathway by dimethyloxalylglycine or hypoxia inhibited sodium transport and decreased expression of β ENaC and γ ENaC, as well as of Na,K-ATPase. HIF1 α silencing increased β ENaC and γ ENaC expression and stimulated sodium transport. A constitutively active mutant of HIF1 α produced the opposite effect. Aldosterone and inhibition of the mitochondrial respiratory chain slowly activated the HIF pathway, suggesting that ROS may also activate HIF. Decreased γ ENaC abundance induced by hypoxia in normal mice was abolished in Hif1α knockout mice. Similarly, Hif1α knockout led to increased γ ENaC abundance under high sodium intake.This study reveals that γ ENaC expression and activity are physiologically controlled by the HIF pathway, which may represent a negative feedback mechanism to preserve oxygenation and/or prevent excessive ROS generation under increased sodium transport.