tbuckley/cabot-search huggingface dataset:
Abstract 2012: Relationship Between Adrenaline Concentration and Postresuscitation Syndrome in Patients with Return of Spontaneous Circulation (ROSC) After Out-of-Hospital Cardiac Arrest
Authors: Kei Nishikawa, Ken Nagao, Kimio Kikushima, Kazuhiro Watanabe, Eizo Tachibana, Takeo Mukohyama, Yoshiteru Tominaga, Katsushige Tada, Nobutaka Chiba, Mitsuru Ishii, Asuka Kasai, Taketomo Soga, Masakazu Matsuzaki, Harumi Ikeda, Yutaka Tateda, Tsukasa Yagi
Journal: Circulation (2007)

Background Although there is evidence that epinephrine hydrochloride favors initial ROSC, there is a paucity of evidence that it improves survival in humans. The value and safety of the Î 2 -adrenergic effects of epinephrine is controversial because they may lead to increase postresuscitation syndrome after ROSC. Few studies have investigated whether adrenaline concentration before epinephrine administration was related to incidence of postresuscitation syndrome. METHODS We did a prospective study of adult patients who achieved ROSC with standard cardiopulmonary resuscitation after out-of-hospital cardiac arrest. Blood samples to measure the adrenaline concentration were taken from a vein. The primary endpoint was neurological outcomes at hospital discharge. RESULTS Of the 274 adult patients with out-of-hospital cardiac arrest, 108(39%) achieved ROSC. The adrenaline levels ranged from 53 to 15,329pg/ml, with a median of 1,545pg/ml, and 25th and 75th percentile values of 707 and 4,486pg/ml, respectively. Of those, 71% (77/108) had an unfavorable neurological outcome and the adrenaline level was higher among such patients than among those with a favorable neurological outcome (a median, 2,016pg/ml vs. 938pg/ml, p=0.048). Moreover, the adrenaline level was higher among patients who died of postresuscitation syndrome within 24 hours of ROSC than among those with survival at 24 hours (a median, 3,290pg/ml vs. 1,343pg/ml, p=0.038). The adrenaline cutoff value of 944pg/ml for unfavorable neurological outcome had an accuracy of 70%. The adjusted odds ratio for the unfavorable neurological outcome after adrenaline cutoff value of 944pg/ml was 8.9 (95% CI, 2.2–35.9; p=0.002). On the other hand, the adrenaline level after epinephrine administration was 28 times as high as that before epinephrine administration (a median, 42,868pg/ml vs. 1,545pg/ml, p&lt;0.0001). CONCLUSIONS In adult patients with ROSC after out-of-hospital cardiac arrest, adrenaline level before epinephrine administration was associated with incidence of postresuscitation syndrome, and the level was extremely increased after epinephrine administration. Epinephrine administration may lead to a severe toxic hyperadrenergic state in postresuscitation period.
Radiation Response of Mammalian Cells Grown in Culture. II. Survival and Recovery Characteristics of Several Subcultures of HeLa S3 Cells After X Irradiation
Authors: R. Z. Lockart, M. M. Elkind, W. B. Moses
Journal: JNCI Journal of the National Cancer Institute (1961)

Three subcultures of HeLa S3 cells, which are of human origin, were studied to determine their response to X rays. The ability of the cells to retain unlimited proliferation was determined by standard tissue-culture techniques for handling single cells. Cells were irradiated with 55 kv X rays delivered at 722 rad per minute. The three subcultures showed characteristic differences in their survival parameters. Two of the subcultures had average mean lethal doses (MLD) near 100 rad, while the third had an average MLD of 131 rad. A range of average extrapolation numbers from 1.4 to 4.9 was observed, and each subculture had a different but characteristic average value. The three subcultures also contained different chromosome complements. It was not possible to correlate either the MLD or the extrapolation number with chromosome complements. In spite of this, surviving cells of all three subcultures were capable of repairing sublethal damage starting immediately after X irradiation. Repeated recovery cycles were also demonstrable when sufficient lengths of time were allowed between doses. In addition to recovery, increases in the MLD of recovered cells in some instances caused the net survival obtained after a given total dose of X rays to be considerably greater when the same total dose was fractionated.
Next-Generation Sequencing Suggests Complex, Heterogeneous Pathogenesis In Peripheral T-Cell Lymphoma Unspecified
Authors: Jonathan H. Schatz, Steven M. Horwitz, Matthew A. Lunning, Igor Dolgalev, Kety Huberman, Adriana Heguy, Agnes Viale, Nicholas D. Socci, Mono Pirun, Julie Teruya-Feldstein, Hans-Guido Wendel
Journal: Blood (2013)
Risk Factors For Acute Pancreatitis In Patients With Acute Lymphoblastic Leukemia
Authors: Chengcheng Liu, Deqing Pei, Meenakshi Devidas, Cheng Cheng, Wenjian Yang, Scott C. Howard, Mignon L. Loh, Paul L. Martin, Naomi J. Winick, William Paul Bowman, Eric C. Larsen, William L. Carroll, Elizabeth A. Raetz, Deepa Bhojwani, Sima Jeha, Ching-Hon Pui, William E. Evans, Stephen P. Hunger, Mary V. Relling
Journal: Blood (2013)
Appropriate comparison would be to compare the best of the old treatments with the best of the new
Authors: H. O'Connor, A. Davies, A. Magos
Journal: BMJ (1995)

after extensive division of ahesions she was found to have moderate diverticular disease of the sigmoid colon with a loop stuck to the left posterolateral aspect of the uterus forming the fistulous communication.Given the degree of adhesions and the anatomy, she underwent a subtotal hysterectomy and oversewing of the colonic defect.Apart from a minor wound infection the remainder of her recovery was uneventful.Presumably the fistula resulted from trauma arising from the conduction of diathermy current during the endometrial ablation.While the introduction of minimally invasive but equiefficacious hysteroscopic techniques should be encouraged, serious complications may still arise.
Abstract 2191: Isolation of Adipose-Derived Stem Cells in Patients with Vascular Disease
Authors: Christopher A DiMatteo, Negar Golesorkhi, Lauren J Fischer, Clinton W Wrigley, Stephen E McIlhenny, Thomas N Tulenko, Irving Shapiro, R. A Carabasi, Joseph Lombardi, Robert A Larson, Paul J DiMuzio
Journal: Circulation (2006)
Cognitive dysfunction (chemobrain) in breast cancer patients receiving adjuvant therapy: A meta-analysis.
Authors: A. T. Lera, A. B. Fede, M. C. Miranda, A. Ueda, T. Lerner, R. A. Cordeiro, M. Okawara, A. Serpa Neto, R. R. Fumis, A. Del Giglio
Journal: Journal of Clinical Oncology (2010)

e19608 Background: Breast cancer is the second cause of mortality in Brazilian women. “Chemobrain” is defined as cognitive changes experienced by patients undergoing chemotherapy, especially in aspects of visual and verbal memory, attention and psychomotor functions. Methods: Review and analysis of articles that address the issue of cognitive dysfunctions related to antineoplastic chemotherapy (chemobrain) in patients with breast cancer published in the Pubmed database in the last 10 years. Results: Nine articles included information that permitted calculation of the relative risk of cognitive dysfunction between cases and controls. The degree of impairment in cognitive function classified as “moderate to high” was present in 145 (28.1%) of patients and in 81 (17.6%) of controls (p=0.0001). In an aggregate of all the studies, the chemotherapy patients had a relative risk estimate to develop moderate to high cognitive dysfunction that was 1.84 times higher than controls (CI 95% 1.46-2.32; p< 0.00001, heterogeneity = 0.03). Main sources of heterogeneity in this study were the timing of the cognitive evaluation (more than versus less than 12 months from chemotherapy) and the type of controls employed (healthy women versus patients before chemotherapy or receiving hormone-therapy). Conclusions: The results presented in this study show that patients with breast cancer who are exposed to adjuvant chemotherapy may suffer from cognitive changes, especially memory deficits. No significant financial relationships to disclose.
The need to integrate liaison psychiatry and geropsychiatry
Authors: Z. J. Lipowski
Journal: American Journal of Psychiatry (1983)

About 30% of medical and surgical inpatients are 65 years old or older, and the latter account for about 30% of referrals for psychiatric consultation. Delirium, dementia, and depressive and anxiety disorders are prevalent in these patients, and liaison psychiatrists are forced to function as (untrained) geropsychiatrists. The author proposes that liaison psychiatrists take over the role of geropsychiatric consultants to elderly medical and surgical inpatients and that fellowships in geropsychiatry-liaison psychiatry be funded to provide appropriate training. Integration of liaison psychiatry and geropsychiatry in general hospitals would provide needed service for the elderly and enhance the stature of liaison psychiatry.
Comparative morphometric analysis of breast-circulating tumor cells and their corresponding solid tumor cytology: A case study.
Authors: E. D. Schram, A. Kolatkar, C. Yoshioka, R. Scuderi, D. Lazar, M. Malchiodi, M. Luttgen, X. Yang, K. Bethel, P. Kuhn
Journal: Journal of Clinical Oncology (2010)

1151 Background: Evaluation of circulating tumor cells (CTCs) from solid tumors is emerging as a clinically relevant tool. Systematic cytometric measurements of CTCs and comparison to their solid tumor counterparts are lacking from the literature to date. Methods: We identified 51 CTCs in 0.5 mL of blood from a patient with metastatic breast cancer, using a slide-based fluorescence assay. We compared images of CTCs to images of tumor cells aspirated from a solid axillary lymph node metastasis. CTCs were imaged using a fluorescent microscope and measurements were made for the CTCs, and a control of 500 WBCs. Images of cells from a solid focus of metastatic tumor were obtained from archival air dried cytology aspirate smears, and similar measurements were made. Results: Measurements show CTC nuclei to be twice the size of circulating WBC nuclei in this patient. The N/C ratios of the tumor cells in the two sites are similar. Using WBCs as a control for nuclear size between specimens, we determined the fixation differences across preparations affects our measurements by a factor of 1.3. Applying this correction factor to our overall cell size measurements, the tumor cells in the metastatic tumor appear 10% larger overall than CTCs. Conclusions: We have quantitatively measured the size of tumor cells in circulation compared to tumor cells from a focus of metastatic solid tumor. Within this patient, N/C ratios of CTCs and tumor cells from a solid metastasis are similar, suggesting that the cell populations in the two sites are not differently differentiated. The smaller average size of CTCs as compared to the tumor cells in the solid metastasis suggests either a filtering effect of the capillary beds proximal to the site of blood collection, with culling of the largest decile of cells, or, morphologically undetectable apoptotic effects on the circulating cells resulting in overall cell shrinkage. Extensive cell measurements from many patients are required to expand these preliminary findings and confirm significance. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Epic Sciences
Spotlight on measles 2010: Measles outbreak in a mainly unvaccinated community in Essen, Germany, March – June 2010
Authors: H Roggendorf, A Mankertz, R Kundt, M Roggendorf
Journal: Eurosurveillance (2010)

On 15 March 2010, a case of measles was reported to the District Health Office in Essen. In total 71 cases occurred from 15 March to 19 May (four cases hospitalised), with the majority linked to a Waldorf school. Only one case had been vaccinated twice, two cases had been vaccinated once. Immediate and consequent exclusion of non-immune children from classes for two weeks as well as the adjacent spring break prevented the wider spread of the virus.
For Debate: The statistical basis of public policy: a paradigm shift is overdue
Authors: R J Lilford, D Braunholtz
Journal: BMJ (1996)

The recent controversy over the increased risk of venous thrombosis with third generation oral contraceptives illustrates the public policy dilemma that can be created by relying on conventional statistical tests and estimates: case-control studies showed a significant increase in risk and forced a decision either to warn or not to warn. Conventional statistical tests are an improper basis for such decisions because they dichotomise results according to whether they are or are not significant and do not allow decision makers to take explicit account of additional evidence--for example, of biological plausibility or of biases in the studies. A Bayesian approach overcomes both these problems. A Bayesian analysis starts with a "prior" probability distribution for the value of interest (for example, a true relative risk)--based on previous knowledge--and adds the new evidence (via a model) to produce a "posterior" probability distribution. Because different experts will have different prior beliefs sensitivity analyses are important to assess the effects on the posterior distributions of these differences. Sensitivity analyses should also examine the effects of different assumptions about biases and about the model which links the data with the value of interest. One advantage of this method is that it allows such assumptions to be handled openly and explicitly. Data presented as a series of posterior probability distributions would be a much better guide to policy, reflecting the reality that degrees of belief are often continuous, not dichotomous, and often vary from one person to another in the face of inconclusive evidence.
Decreasing hospital mortality between 1994 and 1998 in patients with acute myocardial infarction treated with primary angioplasty but not in patients treated with intravenous thrombolysis
Authors: Ralf Zahn, Rudolf Schiele, Steffen Schneider, Anselm K Gitt, Harm Wienbergen, Karlheinz Seidl, Claus Bossaller, Heinz J Büttner, Martin Gottwik, Ernst Altmann, Werner Rosahl, Jochen Senges
Journal: Journal of the American College of Cardiology (2000)
Comparison of 18F-Fluorodeoxyglucose and 18F-Fluorothymidine PET in Differentiating Radiation Necrosis From Recurrent Glioma
Authors: Michael S. Enslow, Lauren V. Zollinger, Kathryn A. Morton, Regan I. Butterfield, Dan J. Kadrmas, Paul E. Christian, Kenneth M. Boucher, Marta E. Heilbrun, Randy L. Jensen, John M. Hoffman
Journal: Clinical Nuclear Medicine (2012)

The objective was to compare F-fluorodeoxyglucose (FDG) and F-fluorothymidine (FLT) PET in differentiating radiation necrosis from recurrent glioma.Visual and quantitative analyses were derived from static FDG PET and static and dynamic FLT PET in 15 patients with suspected recurrence of treated grade 2 glioma or worse with a new focus of Gd contrast enhancement on MRI. For FDG PET, SUVmax and the ratio of lesion SUVmax to the SUVmean of contralateral white matter were measured. For FLT PET, SUVmax and Patlak-derived metabolic flux parameter Kimax were measured for the same locus. A 5-point visual confidence scale was applied to FDG PET and FLT PET. Receiver operating curve analysis was applied to visual and quantitative results. Differences between recurrent tumor and radiation necrosis were tested by Kruskal-Wallis analysis. On the basis of follow-up Gd-enhanced MRI, lesion-specific recurrent tumor was defined as a definitive increase in size of the lesion, and radiation necrosis was defined as stability or regression.For FDG SUVmax, the FDG ratio of lesion-white matter, and FLT Kimax, there was a significant difference between mean values for recurrent tumor and radiation necrosis. Recurrent tumor was best identified by the FDG ratio of lesion-contralateral normal white matter (area under the curve of 0.98, confidence interval of 0.91 to 1.00, sensitivity of 100%, and specificity of 75% for an optimized cutoff value of 1.82).Both quantitative and visual determinations allow accurate differentiation between recurrent glioma and radiation necrosis by both FDG and FLT PET. In this small series, FLT PET offers no advantage over FDG PET.
Abstract 2207: Value of Ventricular Stiffness Index and Ventricular-Arterial Interaction in Predicting Exercise Capacity in Patients with Nonischemic Dilated Cardiomyopathy
Authors: Eui-Young Choi, Sung-Ai Kim, Sang Jae Rhee, Ae Young Her, Chi Young Shim, Jong-Won Ha
Journal: Circulation (2008)

Increased ventricular stiffness and afterload are major contributors to the pathogenesis of heart failure. We sought to investigate whether dilated cardiomyopathy (DCM) patients have distinct ventricular elastance or ventricular-arterial interaction compared to hypertensive patients or healthy controls and they can be used to predict exercise capacity. Twenty-five patients with DCM, 25 age- and gender-matched hypertensive patients, and 25 healthy controls underwent a symptom-limited graded supine bicycle exercise echo after a comprehensive resting echo-Doppler evaluation. Left ventricular (LV) diastolic elastance (Ed, early mitral inflow to anuular velocity/stroke volume), ventricular-vascular coupling index (VVI, Ea/Ees) based on arterial elastance index (Ea, end-systolic pressure/stroke volume) to LV end-systolic elastance index (Ees, peak LV outflow tract velocity to acceleration time) and hemodynamic parameters were measured during exercise test. DCM patients had lower Ees, and higher Ed and VVI with blunted response of Ees and Ea to peak exercise than hypertensive patients or controls. In DCM patients, resting Ees correlated with contractile reserve to low grade exercise (Δsystolic mitral annular velocity to 25W. r=0.561, p=0.004) with close relationship between Ed and VVI (r=0.525, p=0.007 at rest; r=0.510, p=0.047 at 25W exercise). Resting Ed (β=−0.597, p=0.003), VVI (β=−0.523, p=0.010), and total stiffness index (Ed x VVI, β=−0.647, p=0.001) correlated with exercise duration independent of age and gender. Total stiffness index could reliably predict the impaired exercise capacity (&lt;400 sec, 69% sensitivity and 70% specificity). DCM patients have distinct Ed and VVI, which have mutual relationship and predictive power of exercise capacity.
Safety, feasibility, and interest of transthoracic echocardiography in a deployed French military Ebola virus disease treatment center in Guinea
Authors: G R Cellarier, J Bordes, L Karkowski, N Gagnon, M Billhot, J M Cournac, C Rousseau, T De Greslan, C Mac Nab, P Dubrous, S Duron, S Moroge, B Quentin
Journal: Intensive Care Medicine (2015)
Nivolumab in Patients with Relapsed or Refractory Hodgkin Lymphoma - Preliminary Safety, Efficacy and Biomarker Results of a Phase I Study
Authors: Philippe Armand, Stephen M. Ansell, Alexander M. Lesokhin, Ahmad Halwani, Michael M. Millenson, Stephen J. Schuster, John Timmerman, Ivan Borrello, Martin Gutierrez, Emma C. Scott, Deepika Cattry, Bjoern Chapuy, Azra H. Ligon, Scott J. Rodig, Lili Zhu, Joseph F. Grosso, Su Young Kim, Margaret A. Shipp
Journal: Blood (2014)
Abstract 13544: Tissue Fibrosis of Myocardial Biopsy as a Novel Predictor for Adverse Cardiac Events in Patients With Hypertrophic Cardiomyopathy
Authors: Yuko Wada, Takeshi Aiba, Taka-aki Matsuyama, Ikutaro Nakajima, Koji Miyamoto, Yuko Yamada, Hideo Okamura, Takashi Noda, Kazuhiro Satomi, Hideaki Kanzaki, Toshihisa Anzai, Masaharu Ishihara, Kengo F Kusano, Satoshi Yasuda, Shiro Kamakura, Hatsue Ishibashi-Ueda, Wataru Shimizu, Hisao Ogawa
Journal: Circulation (2013)

Background and aim: This study sought to evaluate the level of tissue fibrosis by right ventricular (RV) biopsy in hypertrophic cardiomyopathy (HCM) patients and to assess its relevance to the long...
Kaposis sarcoma and Pneumocystis pneumonia among homosexual men--New York City and California.
Authors: Friedman-Kien A, Laubenstein L, Marmor M, Hymes K, Green J, Ragaz A, Gottleib J, Muggia F, Demopoulos R, Weintraub M
Journal: MMWR Morbidity and Mortality Weekly Report (1981)

Accurate incidence and mortality rates in the US for Kaposis sarcoma are not available but the annual incidence has been estimated at 0.02-0.06/100000.  The disease has tended to affect primarily elder males.  A departure from this pattern is the diagnosis in the past 30 months of Kaposis sarcoma in 26 homosexual men in New York City and California whose mean age was 39 years (range 26-51 years).  In contrast to the clinical course in elderly men in whom the mean survival time is 8-13 years after diagnosis 8 of the homosexual patients died within 2 years after diagnosis.  A review of the New York University Coordinated Cancer Registry for Kaposis sarcoma revealed no such cases in men under 50 years of age for the 1970-79 period.  Presenting complaints in 20 of the homosexual men included skin lesions only (50%) and skin lesions plus lymphadenopathy (20%).  After the initial physician visit 6 patients developed pneumonia and 1 had necrotizing toxoplasmosis of the central nervous system.  Serologic evidence of past or present cytomegalovirus infection was found in all 12 patients who were tested.  Also of concern is the incidence of 15 cases of Pneumocystis in homosexual men in California since 1979.  These findings indicate that physicians should be alert for Kaposis sarcoma Pneumocystis pneumonia and other opportunistic infections associated with immunosuppression in homosexual men.
Autoimmune Polyendocrine Syndrome Type 1 : NALP5 in Autoimmune Polyendocrine Syndrome Type 1
Authors: Mohammad Alimohammadi, Peyman Björklund, Åsa Hallgren, Nora Pöntynen, Gabor Szinnai, Noriko Shikama, Marcel P. Keller, Olov Ekwall, Sarah A. Kinkel, Eystein S. Husebye, Jan Gustafsson, Fredrik Rorsman, Leena Peltonen, Corrado Betterle, Jaakko Perheentupa, Göran Åkerström, Gunnar Westin, Hamish S. Scott, Georg A. Holländer, Olle Kämpe
Journal: New England Journal of Medicine (2006)

Background Autoimmune polyendocrine syndrome type 1 (APS-1) is a multiorgan autoimmune disorder caused by mutations in AIRE, the autoimmune regulator gene. Though recent studies concerning AIRE def ...
Abstract 14330: Effect of Strut Thickness on Atherosclerotic Change in Neointima Over An Extended Follow-up Period (>= 5 Years) after Bare-metal Stent Implantation: In Vivo Optical Coherence Tomography Study
Authors: Hironori Kitabata, Kohei Ishibashi, Kenichi Komukai, Takashi Tanimoto, Yasushi Ino, Keizo Kimura, Kumiko Hirata, Masato Mizukoshi, Toshio Imanishi, Takashi Akasaka
Journal: Circulation (2010)
Epidemiology and control of influenza A(H1N1)v in the Netherlands: the first 115 cases
Authors: S Hahné, T Donker, A Meijer, A Timen, J van Steenbergen, A D Osterhaus, M van der Sande, M Koopmans, J Wallinga, R Coutinho, Collective the Dutch New Influenza A(H1N1)v Investigation Team
Journal: Eurosurveillance (2009)

Introductions of the new influenza A(H1N1) variant virus in the Netherlands led to enhanced surveillance and infection control. By 24 June 2009, 115 cases were reported, of whom 44% were indigenously acquired. Severity of disease is similar to reports elsewhere. Our point estimate of the effective reproductive number (Re) for the initial phase of the influenza A(H1N1)v epidemic in the Netherlands was below one. Given that the Re estimate is based on a small number of indigenous cases and a limited time period, it needs to be interpreted cautiously.