tbuckley/cabot-search huggingface dataset:
A Randomized Phase II Study of MEDI0680 in Combination with Durvalumab versus Nivolumab Monotherapy in Patients with Advanced or Metastatic Clear-cell Renal Cell Carcinoma
Authors: Martin H. Voss, Arun A. Azad, Aaron R. Hansen, Jhanelle E. Gray, Sarah J. Welsh, Xuyang Song, Michael Kuziora, Lina Meinecke, Jorge Blando, Ikbel Achour, Yi Wang, Farzana L. Walcott, Sjoukje F. Oosting
Journal: Clinical Cancer Research (2022)

Abstract Purpose: MEDI0680 is a humanized anti–programmed cell death-1 (PD-1) antibody, and durvalumab is an anti-PD-L1 antibody. Combining treatment using these antibodies may improve efficacy versus blockade of PD-1 alone. This phase II study evaluated antitumor activity and safety of MEDI0680 plus durvalumab versus nivolumab monotherapy in immunotherapy-naïve patients with advanced clear-cell renal cell carcinoma who received at least one prior line of antiangiogenic therapy. Patients and Methods: Patients received either MEDI0680 (20 mg/kg) with durvalumab (750 mg) or nivolumab (240 mg), all intravenous, every 2 weeks. The primary endpoint was investigator-assessed objective response rate (ORR). Secondary endpoints included best overall response, progression-free survival (PFS), safety, overall survival (OS), and immunogenicity. Exploratory endpoints included changes in circulating tumor DNA (ctDNA), baseline tumor mutational burden, and tumor-infiltrated immune cell profiles. Results: Sixty-three patients were randomized (combination, n = 42; nivolumab, n = 21). ORR was 16.7% [7/42; 95% confidence interval (CI), 7.0–31.4] with combination treatment and 23.8% (5/21; 95% CI, 8.2–47.2) with nivolumab. Median PFS was 3.6 months in both arms; median OS was not reached in either arm. Because of adverse events, 23.8% of patients discontinued MEDI0680 and durvalumab and 14.3% of patients discontinued nivolumab. In the combination arm, reduction in ctDNA fraction was associated with longer PFS. ctDNA mutational analysis did not demonstrate an association with response in either arm. Tumor-infiltrated immune profiles showed an association between immune cell activation and response in the combination arm. Conclusions: MEDI0680 combined with durvalumab was safe and tolerable; however, it did not improve efficacy versus nivolumab monotherapy.
176P Poziotinib for HER2-positive metastatic breast cancer (MBC): Final clinical efficacy and safety results for long-term follow-up of the phase II NOV120101-203 trial
Authors: Y.H. Park, K.H. Jung, J. Sohn, K.S. Lee, J.H. Kim, Y. Yang, E. Baek, H. Han, S-A. Im
Journal: Annals of Oncology (2022)
Validation of the Kansas City Cardiomyopathy Questionnaire in Symptomatic Obstructive Hypertrophic Cardiomyopathy
Authors: Michael Nassif, Jennifer T. Fine, Chantal Dolan, Matthew Reaney, Prithvi Addepalli, Veleka D. Allen, Amy J. Sehnert, Kensey Gosch, John A. Spertus
Journal: JACC Heart Failure (2022)

The primary goal for treating patients with obstructive hypertrophic cardiomyopathy (oHCM) is to improve their symptoms, function, and quality of life. Although the Kansas City Cardiomyopathy Questionnaire (KCCQ) is a valid, reliable, and sensitive measure for other etiologies of heart failure, its appropriateness for patients with oHCM is unknown. The purpose of this study was to establish the interpretability, validity, reliability, and responsiveness of the KCCQ in patients with oHCM. Cognitive debriefing of the KCCQ was performed in 26 patients with oHCM. The validity, reliability, responsiveness, and interpretability of the KCCQ were tested in 196 participants from the EXPLORER-HCM trial by comparing each scale with relevant comparators, describing the internal reliability and the mean change in stable patients, and comparing the mean change in patients who reported different degrees of clinical change using a patient-reported global impression of change (PGIC). All KCCQ domains demonstrated strong correlations with external standards of symptoms, function, social limitation, and quality of life, including a recently designed instrument measuring symptoms not captured by the KCCQ (P < 0.0001 for all). Mean changes in stable patients were nonsignificant, ranging from 0.21 to 2.3 points (P > 0.30 for all), with high intraclass correlation coefficients. The mean changes in patients with small, moderate, and large clinical changes were consistent with the 5-, 10-, and 20-point mean differences observed in other etiologies of heart failure. The KCCQ is well understood by patients with oHCM and has strong evidence of good psychometric performance. It can not only serve as a relevant endpoint in clinical trials of oHCM therapy, but may also prove useful in the clinical care of patients with oHCM. (Clinical Study to Evaluate Mavacamten [MYK-461] in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy [EXPLORER-HCM]; NCT03470545)
THE OTHER SIDE OF THE MOON: ROLE OF CAPSULE AND DOUBLE BALLOON ENTEROSCOPY IN PATIENTS WITH INDICATION OTHER THAN SUSPECTED SMALL BOWEL BLEEDING
Authors: L. Scaramella, M. Topa, R. Penagini, M. Vecchi, G.E. Tontini, M. Pennazio, R. Sidhu, D.S. Sanders, L. Elli
Journal: Endoscopy (2022)

Aims The use of videocapsule and double balloon enteroscopy (VCE, DBE), in patients with indications other than suspected small bowel bleeding (nSSBB) is largely unknown. Our aim was to assess their role in patients with nSSBB.
TREATMENT OF RECURRENCES AFTER ENDOSCOPIC MUCOSAL RESECTION OF LARGE NON-PEDUNCULATED COLORECTAL POLYPS IN DAILY CLINICAL PRACTICE IS CHALLENGING
Authors: A.S. Turan, E. Antonius, J. Terhaar sive Droste, R.W. Schrauwen, R.-M. Schreuder, J.W. Straathof, N. Pijnenborg, P.D. Siersema, E.J. Van Geenen
Journal: Endoscopy (2022)

Aims Recurrence during surveillance after endoscopic mucosal resection (EMR) of non-pedunculated colorectal polyps≥20mm occurs in approximately 20% and endoscopic resection of recurrences is not always successful. We evaluated recurrence rates after colorectal EMR of polyps≥20 mm in daily clinical practice and the success of treatment of recurrent adenoma.
EUS-GUIDED GASTRO-BULBOSTOMY (EUS-GBS) WITH LUMEN-APPOSING METAL STENT (LAMS) AS A ROUTE FOR ERCP IN UPSIDE-DOWN STOMACH (UDS)
Authors: C. Maroto-Martin, L. Sanchez-Delgado, R. Sanchez-Ocana, J.A. Estradas-Trujillo, M. Sciarretta, C. de la Serna, M. Perez-Miranda
Journal: Endoscopy (2022)

Case A duodenoscope loops into an UDS preventing pyloric passage. A dilated CBD is imaged with a linear echoendoscope. EUS-guided transgastric cholangiography confirms choledocholithiasis. An 8.5F nasobiliary tube is placed through the pylorus into the duodenum. Contrast, saline and methylene-blue injection through the tube outline and distend the bulb next to the stomach. A 20x10mm cautery-enabled LAMS is placed for gastro-bulbostomy and balloon-dilated. A duodenoscope is passed through the LAMS for sphincterotomy and stone removal.
ENDOSCOPIC MINOR PAPILLA SPHINCTEROTOMY IN PATIENTS WITH PANCREAS DIVISUM AND ACUTE RECURRENT PANCREATITIS: A METANALYSIS
Authors: T. Schepis, A. Tringali, P. Familiari, I. Boskoski, V. Perri, G. Costamagna
Journal: Endoscopy (2022)

Aims Pancreas divisum (PD) is a common congenital variant of the pancreatic ductal system and a potential cause of acute recurrent pancreatitis (ARP). Endoscopic minor papilla sphincterotomy (MiES) is the most common procedure performed in the management of PD-related ARP. The aim of this study is to perform a metanalysis estimating the efficacy and the safety of MiES in the management of patients with PD-related ARP.
ENDOSCOPIST PERFORMANCE IN OPTICAL DIAGNOSIS OF COLORECTAL POLYPS IN ARTIFICIAL INTELLIGENCE STUDIES
Authors: S. Pecere, G. Antonelli, M. Dinis-Ribeiro, Y. Mori, C. Hassan, L. Fuccio, R. Bisschops, G. Costamagna, E.H. Ji, D. Lee, M. Misawa, H. Messmann, F. Iacopini, L. Petruzziello, A. Repici, Y. Saito, P. Sharma, M. Yamada, C. Spada, L. Frazzoni
Journal: Endoscopy (2022)

Aims Widespread adoption of optical diagnosis of colorectal neoplasia is prevented by suboptimal endoscopist performance and lack of standardized training and competence evaluation.
Genetic resiliency associated with dominant lethal TPM1 mutation causing atrial septal defect with high heritability
Authors: Polakit Teekakirikul, Wenjuan Zhu, Xinxiu Xu, Cullen B. Young, Tuantuan Tan, Amanda M. Smith, Chengdong Wang, Kevin A. Peterson, George C. Gabriel, Sebastian Ho, Yi Sheng, Anne Moreau de Bellaing, Daniel A. Sonnenberg, Jiuann-huey Lin, Elisavet Fotiou, Gennadiy Tenin, Michael X. Wang, Yijen L. Wu, Timothy Feinstein, William Devine, Honglan Gou, Abha S. Bais, Benjamin J. Glennon, Maliha Zahid, Timothy C. Wong, Ferhaan Ahmad, Michael J. Rynkiewicz, William J. Lehman, Bernard Keavney, Tero-Pekka Alastalo, Mary-Louise Freckmann, Kyle Orwig, Steve Murray, Stephanie M. Ware, Hui Zhao, Brian Feingold, Cecilia W. Lo
Journal: Cell Reports Medicine (2022)

Analysis of large-scale human genomic data has yielded unexplained mutations known to cause severe disease in healthy individuals. Here, we report the unexpected recovery of a rare dominant lethal mutation in TPM1, a sarcomeric actin-binding protein, in eight individuals with large atrial septal defect (ASD) in a five-generation pedigree. Mice with Tpm1 mutation exhibit early embryonic lethality with disrupted myofibril assembly and no heartbeat. However, patient-induced pluripotent-stem-cell-derived cardiomyocytes show normal beating with mild myofilament defect, indicating disease suppression. A variant in TLN2, another myofilament actin-binding protein, is identified as a candidate suppressor. Mouse CRISPR knock-in (KI) of both the TLN2 and TPM1 variants rescues heart beating, with near-term fetuses exhibiting large ASD. Thus, the role of TPM1 in ASD pathogenesis unfolds with suppression of its embryonic lethality by protective TLN2 variant. These findings provide evidence that genetic resiliency can arise with genetic suppression of a deleterious mutation.
COVID SCREENING IN THE ENDOSCOPY UNIT OF ELCHE UNIVERSITY HOSPITAL (SPAIN)
Authors: J. Barragán Martínez, A. Ojeda Gómez, A. Brotons Brotons, A.M. Íñigo Chaves, F.E. Uceda Porta, M. Gutiérrez Alonso, V. Cañizares Molina, M. Vílchez Vílchez, M.D. Esteve Martínez, M. Boix Macia, R. Aniorte Blasco, A. García Soria, J. Sáez Fuster, M.F. García Sepulcre, F.J. Sola-Vera Sánchez
Journal: Endoscopy (2022)

Aims Due to COVID-19 pandemic, the Endoscopy Unit of Elche University Hospital decided to do clinical, epidemiological and microbiological screening prior to any endoscopic procedure, in addition to the use personal protective equipment. The aim of this study is to assess the impact of these actions on COVID-19 transmission among the patients and the staff; and also to identify when microbiological screening is not necessary.
MOTORIZED SPIRAL ENTEROSCOPE GUIDED BILIARY INTERVENTION FOR RELIEF OF OBSTRUCTIVE JAUNDICE IN PATIENT WITH HEPATICOJEJUNOSTOMY
Authors: C.R. Achanta, S. Kinhal, V. Imandi, A. Singh
Journal: Endoscopy (2022)

A 47-year-old male with hepaticojejunostomy (HJ) done for postcholecystectomy biliary injury 2 years ago, presented with recurrent jaundice, abdominal pain, intermittent fever for three months.Workup showed serum bilirubin-21.7 mg/dl, alkaline phosphatase-347 IU/ml, WBC count-18300/mm3. MRCP showed dilated biliary radicles with HJ site stricture. Motorized spiral enteroscope-guided ERCP was done under general anesthesia. HJ site was identified 50 cm distal to the jejunojejunostomy site. Cholangiogram showed prominent biliary radicles with multiple filling defects. HJ stricture was dilated with a 6 mm balloon, and black pigmented stones were suctioned out. A 7 Fr pigtail plastic stent was placed. He was discharged later.
Event-free Survival with Pembrolizumab in Early Triple-Negative Breast Cancer
Authors: Peter Schmid, Javier Cortes, Rebecca Dent, Lajos Pusztai, Heather McArthur, Sherko Kümmel, Jonas Bergh, Carsten Denkert, Yeon Hee Park, Rina Hui, Nadia Harbeck, Masato Takahashi, Michael Untch, Peter A. Fasching, Fatima Cardoso, Jay Andersen, Debra Patt, Michael Danso, Marta Ferreira, Marie-Ange Mouret-Reynier, Seock-Ah Im, Jin-Hee Ahn, Maria Gion, Sally Baron-Hay, Jean-François Boileau, Yu Ding, Konstantinos Tryfonidis, Gursel Aktan, Vassiliki Karantza, Joyce O’Shaughnessy
Journal: New England Journal of Medicine (2022)

The addition of pembrolizumab to neoadjuvant chemotherapy led to a significantly higher percentage of patients with early triple-negative breast cancer having a pathological complete response (defined as no invasive cancer in the breast and negative nodes) at definitive surgery in an earlier analysis of this phase 3 trial of neoadjuvant and adjuvant therapy. The primary results regarding event-free survival in this trial have not been reported.
CHANGES IN EXAMINER BEHAVIOR CAUSED BY A COMPUTER-AIDED SYSTEM FOR POLYP DETECTION
Authors: J. Troya, D. Fitting, M. Brand, B. Sudarevic, J.N. Kather, A. Meining, A. Hann
Journal: Endoscopy (2022)

Aims Multiple computer-aided systems for polyp detection (CADe) are currently introduced into clinical practice, with an unclear effect on examiner behavior. In particular, false positive detections could lead to prolonged examination time due to frequent misinterpretations of normal mucosa. In this work, we aimed to measure the influence of a CADe system on reaction time, mucosa misinterpretations, and changes in visual gaze pattern.
GASTROENTEROANASTOMOSIS UNDER ENDOSCOPIC ULTRASOUND GUIDANCE USING METAL LUMEN APPOSING STENT (HOT-AXIOS​): SINGLE-CENTER EXPERIENCE
Authors: Á.M. Montero Moretón, F. Santos Santamarta, E. González de Castro, L.F. Aguilar Argeñal, D. Robles de la Osa, B.A. Moreira da Silva, M. Cimavilla Román, M. Curieses Luengo, S. Maestro Antolín, F. Rancel Medina, J. Santos Fernández, L. Pérez Citores, J. Barcenilla Laguna, A.G. Pérez Millan
Journal: Endoscopy (2022)

Aims Gastrointestinal tract obstruction has classically only been able to be solved by surgical techniques. Recent advances in endoscopic ultrasound and the appearance of metallic luminal apposition stents (LAS) have demonstrate an alternative for the treatment of obstructions at the level of the antrum and duodenum being their indication mainly palliative. The present study tries to be one more confirmation of the safety and effectiveness of the technique.
GENETIC STUDY OF THE VIRULENCE FACTORS CAG A AND VACA OF HELICOBACTER PYLORI AND THEIR IMPLICATION IN GASTRIC CARCINOGENESIS
Authors: I. Essaidi, I. Elyounsi, M.R. Jouimyi, G. Bounder, H. Boura, H. Benomar, K. Zerouali, F. Maachi
Journal: Endoscopy (2022)

Aims The aim of our work is to study the association of genetic polymorphisms in the cagA and vacA genes with the risk of developing gastric lesions.
Pembrolizumab versus placebo as adjuvant therapy in completely resected stage IIB or IIC melanoma (KEYNOTE-716): a randomised, double-blind, phase 3 trial
Authors: Jason J Luke, Piotr Rutkowski, Paola Queirolo, Michele Del Vecchio, Jacek Mackiewicz, Vanna Chiarion-Sileni, Luis de la Cruz Merino, Muhammad A Khattak, Dirk Schadendorf, Georgina V Long, Paolo A Ascierto, Mario Mandala, Federica De Galitiis, Andrew Haydon, Reinhard Dummer, Jean-Jacques Grob, Caroline Robert, Matteo S Carlino, Peter Mohr, Andrew Poklepovic, Vernon K Sondak, Richard A Scolyer, John M Kirkwood, Ke Chen, Scott J Diede, Sama Ahsan, Nageatte Ibrahim, Alexander M M Eggermont
Journal: The Lancet (2022)
SAME SESSION DIAGNOSTIC EUS AND ERCP FOLLOWING GATE PROCEDURE (GASTRIC ACCESS TEMPORARY FOR ENDOSCOPY) IN A PATIENT WITH OBSTRUCTIVE JAUNDICE AND GASTRIC BYPASS ANATOMY
Authors: M. Lajin
Journal: Endoscopy (2022)

A 64-year-old female with a history of gastric bypass presented with jaundice and a 40-pound weight loss. MRCP showed cholelithiasis without choledocholithiasis, both CBD and PD were dilated. CT with contrast showed no pancreatic mass.
EVALUATION OF COLONOSCOPY SATISFACTION AND SAFETY INDICATORS WITH THE COLONOSCOPY SATISFACTION AND SAFETY QUESTIONNAIRE BASED ON PATIENT EXPERIENCE (CSSQP)
Authors: A. Brotons, C. Mangas-Sanjuan, A. Ojeda, J. Cubiella, L. Cid-Gómez, P. Díez-Redondo, A. Seoane, S. García-Mateo, A. Suárez, D. Nicolás-Pérez, B. Lumbreras, J.J. Mira, J. Sola-Vera, R. Jover
Journal: Endoscopy (2022)

Aims Recommendations for improving the quality of colonoscopy include collecting data on patient experience with validated questionnaires. The Colonoscopy Satisfaction and Safety Questionnaire based on Patient experience (CSSQP) was recently developed and validated within the Spanish Bowel Cancer Screening Program. The present multicenter study aimed to apply the CSSQP to identify factors related to patient experiences, including all the indication for colonoscopy.
ESOPHAGEAL STENT PLACEMENT FOR THE TREATMENT OF ANASTOMOTIC LEAK
Authors: P. Ladrón Abia, A. Mínguez Sabater, S. Martínez Delgado, N. Alonso, L. Argüello, M. García Campos, M. Bustamante Bailén, V. Lorenzo-Zúñiga, V. Pons
Journal: Endoscopy (2022)

Aims Evaluate the efficacy and safety of esophageal stent placement for the treatment of post-surgical esophageal anastomotic leaks.
EUS-GUIDED GASTROJEJUNOSTOMY TO PALLIATE A MALIGNANT DUODENAL OBSTRUCTION IN A PATIENT WITH LOCALLY-ADVANCED PANCREATIC CANCER
Authors: M. Lajin
Journal: Endoscopy (2022)

A 72-year-old male with a recently diagnosed locally advanced pancreatic cancer presented with vomiting. A CT revealed duodenal obstruction at D3.
RETROSPECTIVE ANALYSIS OF THE UTILITY OF THE PATENCY CAPSULE IN CAPSULE ENDOSCOPY
Authors: F. O'Hara, D. McNamara, C. Walker
Journal: Endoscopy (2022)

Aims Capsule retention is a serious complication of capsule endoscopy. Retention rates range from 1% to 4.8%. The introduction of patency capsules has had a major role improving this. The aim was to analyse usage of patency test in our institute against guidelines.
STUDY ON THE SAFETY AND EFFICACY OF NOVEL MOTORIZED SPIRAL ENTEROSCOPE IN THE DIAGNOSIS AND THERAPY OF SMALL BOWEL DISEASES: A RETROSPECTIVE MULTICENTRE EXPERIENCE
Authors: C.R. Achanta, S. Kinhal, V. Imandi, A. Singh, S. Sundaram, K. Mane, M. Panigrahi, M.I. Chouhan, S. Hanumanthu, R.M. Kunchala
Journal: Endoscopy (2022)

Aims We share our experience on the efficacy and safety of Novel motorized spiral enteroscope (NMSE) in small bowel diseases
CAN WE PREDICT A POSSIBLE MALIGNANCY BEFORE ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY (ERCP)?
Authors: A. Yavuz, K. Akan, I. Tuncer
Journal: Endoscopy (2022)

Methods In a retrospective single-center study, we investigated the ERCP records of patients between 12.2016- 04.2021. All patients had abdominal imaging before the ERCP. Laboratory parameters were derived at the time of admission. Statistical analyses were performed using SPSS. Receiver operating characteristic (ROC) curve analysis was used to determine the cut-off values for predicting malignancy pre-ERCP.
38P Tumour-infiltrating lymphocytes and correlation with prognostic signature scores in early-stage hormone-positive, HER2-negative (ER+/HER2-) breast cancer
Authors: M.W. Lucas, Z. Kinsella, C. Gonzalez, C. Hurley, A. Blümel, T. O'Grady, V. Murphy, C. Jahangir, C. Burke, A. Rahman, C.M. Kelly, W.M. Gallagher, D. O'Connor
Journal: Annals of Oncology (2022)
Diabetes Incidence Among Hispanic/Latino Adults in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Authors: Christina Cordero, Neil Schneiderman, Maria M. Llabre, Yanping Teng, Martha L. Daviglus, Catherine C. Cowie, Jianwen Cai, Gregory A. Talavera, Linda C. Gallo, Robert C. Kaplan, Elizabeth M. Cespedes Feliciano, Rebeca A. Espinoza Giacinto, Aida L. Giachello, Larissa Avilés-Santa
Journal: Diabetes Care (2022)

OBJECTIVE To examine diabetes incidence in a diverse cohort of U.S. Hispanic/Latinos. RESEARCH DESIGN AND METHODS The Hispanic Community Health Study/Study of Latinos is a prospective cohort study with participants aged 18–74 years from four U.S. metropolitan areas. Participants were assessed for diabetes at the baseline examination (2008–2011), annually via telephone interview, and at a second examination (2014–2017). RESULTS A total of 11,619 participants returned for the second examination. The overall age-adjusted diabetes incidence rate was 22.1 cases/1,000 person-years. The incidence was high among those with Puerto Rican and Mexican backgrounds as well as those aged ≥45 years and with a BMI ≥30 kg/m2. Significant differences in diabetes awareness, treatment, and health insurance coverage, but not glycemic control, were observed across Hispanic/Latino background groups, age groups, and BMI categories. CONCLUSIONS Differences in diabetes incidence by Hispanic/Latino background, age, and BMI suggest the susceptibility of these factors.
ENDOSCOPIC SUBMUCOSAL DISSECTION OF A SOLITARY GASTRIC PLASMOCYTOMA: 'THIRD SPACE ODDITY'
Authors: G. Rasschaert, P. Gkolfakis, P. Eisendrath, L. Verset, J. Devière, A. Lemmers
Journal: Endoscopy (2022)

A 35-year-old woman underwent esophagogastroduodenoscopy for progressive epigastralgia. A 10mm subepithelial antral lesion contained plasmocytoma tissue. Diagnostic work up was negative apart from a gastric focus on PET.
Development of chimeric forms of the matrix metalloproteinase 2 collagen binding domain as artificial membrane binding proteins for targeting stem cells to cartilage lesions in osteoarthritic joints
Authors: Anais Dabbadie, Anna Salerno, Adam Perriman, Lu-Yun Lian, Anthony P. Hollander
Journal: Biomaterials (2022)

Targeting stem cells to cartilage lesions has the potential to enhance engraftment and chondrogenesis. Denatured type II collagen fibrils (gelatin) are exposed in lesions at the surface of osteoarthritic articular cartilage and are therefore ideal target sites. We have designed and investigated chimeric mutants of the three modules of the MMP-2 collagen binding domain (CBD) as potential ligands for stem cell targeting. We expressed full-length CBD for the first time and used it to identify the most important amino acid residues for binding to gelatin. Module 2 of CBD had the highest affinity binding to both Type I and Type II gelatin, whereas module 1 showed specificity for type II gelatin and module 3 for type I gelatin. We went on to generate chimeric forms of CBD consisting of three repeats of module 1 (111), module 2 (222) or module 3 (333). 111 lacked solubility and could not be further characterised. However 222 was found to bind to type II gelatin 14 times better than CBD, suggesting it would be optimal for attachment to cartilage lesions, whilst 333 was found to bind to type I gelatin 12 times better than CBD, suggesting it would be optimal for attachment to lesions in type I collagen-rich tissues. We coated 222 onto the external membrane of Mesenchymal Stem Cells and demonstrated higher attachment of the coated cells to type II gelatin than uncoated cells. We conclude that the three modules of CBD each have specific biological properties that can be exploited for targeting stem cells to cartilage lesions and other pathological sites.
DEVELOPMENT AND VALIDATION OF A NOVEL SCORE FOR THE COMPLETENESS OF CAECAL INTUBATION – THE CCIS (COMPLETENESS OF CAECAL INTUBATION SCORE)
Authors: L. Crapé, L. Debels, C. Schoonjans, J. Anderson, R. Valori, L. Desomer, D. Tate
Journal: Endoscopy (2022)

Aims 5-10% of colorectal cancers (CRC) are post-colonoscopy CRC. Potential causes include incomplete caecal visualisation. We created and validated the Completeness of Caecal Intubation Score (CCIS) as a potential new colonoscopy key performance indicator (KPI).
Technique for fine adjustment of snare size during endoscopic mucosal resection by a single endoscopist
Authors: Jihwan Ko
Journal: Endoscopy (2022)

Performing endoscopic mucosal resection for polyps located in the hepatic flexure is always challenging. The two most important reasons that make removing polyps in the hepatic flexure difficult are the instability of the position of the endoscope and the difficulty in advancing the endoscope's accessories while in that bent angle. To overcome the instability of the endoscopic position, the left pinkie maneuver can be applied [1]. The cases shown here demonstrate that an "open-and-retract maneuver of the snare" could solve the approach problem ([Video 1]).