AB0737 THE NAIL FOLD CAPILLAROSCOPIC FINDINGS OF ADOLESCENTS WITH ANOREXIA NERVOSA AND BULIMIA NERVOSA
Authors: M. Kasap-Cuceoglu, M. Pehlivanturk-Kizilkan, E. Sag, S. Sener, Z. Balik, S. Akgul, O. Derman, Y. Bilginer, N. Kanbur, S. Özen
Journal: Annals of the Rheumatic Diseases (2021)

Background: The nail fold video capillaroscopy (NVC) is usually performed on patients with microcirculation problems, such as Raynaud’s phenomenon. It is also used to distinguish between primary and secondary Raynaud’s Phenomenon and identify the scleroderma pattern. Objectives: To describe the acute phase nail fold capillaroscopic findings of adolescents with anorexia nervosa (AN) and bulimia nervosa (BN) and to compare these findings with adolescents diagnosed with primary Reynaud’s phenomenon (RP). Methods: We included 17 AN, 2 BN patients and 6 adolescents with primary RP as a control group. The nail fold video capillaroscopy (NVC) data of three study groups were compared. AN and BN patients were classified according to DSM-5. The participants in these two groups were assessed for the presence of Reynaud’s phenomenon/acrocyanosis and the weight loss history (amount and duration), daily calorie intake, vital signs, hydration status, amenorrhea presence and time, the presence and frequency of compensatory behaviors, and drug usage were recorded. Adolescents with primary RP were diagnosed according to ‘International consensus criteria for the diagnosis of RP. The initial NVC was performed at the acute phase of AN and BN. For AN acute phase is defined as the period where the nutritional rehabilitation has not yet taken place. The NVC analysis was be performed with a digital USB microscopy by an expert blinded to the participant’s clinical status and diagnosis. Eight fingers were evaluated for each patient and average of all fingers’ scores were used as quantitative measures. Results: Among adolescents with AN, 14 of them had enlarged capillaries (capillary diameter 20-50 μm) and 6 of them had mild tortuosity (&lt;50%) which were considered as minor capillaroscopic changes. 5 patients had at least one giant capillary (&gt;50μm), 3 of them had microhemorrhages, 4 of them had capillary ramifications, and 1 of them had capillary disorganization which were considered as major capillaroscopic changes. Two adolescents had capillary loss (6 capillaries/mm). None of them had active or late phase scleroderma findings. In the primary RP group, there were minor findings as five adolescents had mild capillary dilation (capillary diameter 20-50 μm), and 5 had mild tortuosity (&lt;50%). However, none had scleroderma (early-active-late phase) findings. Microangiopathy assessment scores revealed no difference between the AN patients with and without RP and primary RP patients.(Table 1) A positive correlation was found between capillary ramification scores and initial daily calorie intake (r: -0.47; p=0.04). Table 1. Measurements of capileroscopy findings according to patient groups AN+RP+ n=4 AN+RP - n=13 BN n=2 Primer RP kontrol n=6 p Microangiopathy score 0.84 (IQR 0.98) 0.92 (IQR 0.96) 0.71 0.65 (IQR0.23) 0.62 •Capillary loss score 0.22 (IQR 0.62) 0.06 (IQR 0.41) 0.15 0.0 (IQR 0.26) 0.58 •Capillary ramification score 0.18 (IQR 0.25) 0.13 (IQR 0.25) 0.09 0.09 (IQR 0.18) 0.88 •Disorganized capillaries score 0.38 (IQR 0.48) 0.56 (IQR 0.68) 0.46 0.43 (0.32) 0.98 Enlarged capillaries score (20-50 μm) 0.56 (IQR 0.78) 0.31 (IQR 0.72) 0.73 0.58 (IQR 0.42) 0.60 Giant capillaries score (&gt;50 μm) 0.06 (IQR 0.22) 0.00 (IQR 0.03) 0.18 0.03 (0.14) 0.14 Microhaemorrhage score 0.00 0.00 0.00 0.01 0.67 Conclusion: Preliminary results of our study suggest that adolescents with AN are at risk for vasculopathy especially during the acute phase of the disease. References: [1]Smith V, et al Autoimmun Rev. 2020 Mar;19(3):102458. [2]American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders (DSM-5). American Psychiatric Pub, Arlington Acknowledgements: Muserref Kasap-Cuceoglu and Melis Pehlivanturk-Kizilkan contributed equally. Disclosure of Interests: None declared