tbuckley/cabot-search huggingface dataset:
Gradual changes of ECG waveform during and after exercise in normal subjects.
Authors: M LSimoons, P GHugenholtz
Journal: Circulation (1975)

The directions and magnitudes of time-normalized P, QRS, and ST vectors, and other ECG parameters were analyzed during and after multistage exercise in 56 ostensibly healthy men aged 23 to 62. By selective averaging with a digital computer system a single representative beat was obtained from each stage. Measurements were taken from this beat. During exercise, the interval between the spatial maximum of the P wave and the onset of the QRS complex decreased while the magnitude of the P wave increased. The direction of the P vectors did not change. This pattern corresponds to the electrocardiographic manifestations of predominant right atrial overload. No significant changes in the QRS duration were observed. Also the magnitude and spatial orientation of the maximum QRS vectors remained constant. The interval between the QRS onset and the maximum spatial magnitude of the T wave shortened. The terminal QRS vectors and the ST vectors gradually shifted toward the right, and superiorly. The T magnitude lessened...
Long QT syndrome. New electrocardiographic characteristics.
Authors: JBenhorin, MMerri, MAlberti, ELocati, A JMoss, W JHall, LCui
Journal: Circulation (1990)

The long QT syndrome is electrocardiographically characterized by a prolonged QT interval and by several other, more subtle, ST-T-U wave abnormalities, most of which have not been quantified. To determine the possible usefulness of several new electrocardiographic characteristics in identifying patients with known long QT syndrome, logistic regression models were applied to a data base of seven new, relatively independent, electrocardiographic repolarization variables. These were measured on digitized 12-lead electrocardiograms of 315 normal subjects and 37 patients with the long QT syndrome (members of well-identified long QT syndrome families, QTc greater than 0.44 second, 27% symptomatic), who ranged in age from 17 to 60 years. Electrocardiographic variables that independently differentiated (p less than 0.001) patients with long QT syndrome from normal subjects included quantitative measures of repolarization: early duration, rate, T wave symmetry, late phenomena, and heterogeneity. All selected repol...
Adaptation to ischemia during percutaneous transluminal coronary angioplasty. Clinical, hemodynamic, and metabolic features.
Authors: EDeutsch, MBerger, W GKussmaul, J WHirshfeld, H CHerrmann, W KLaskey
Journal: Circulation (1990)

The clinical, electrocardiographic, and coronary hemodynamic responses to sequential 90-second occlusions of the left anterior descending coronary artery in 12 patients undergoing elective percutaneous transluminal coronary angioplasty were examined. Transmyocardial lactate metabolism was examined in an additional group of seven patients with clinical and hemodynamic features similar to the first group. We noted that in comparison with the initial balloon occlusion the second occlusion was characterized by less subjective anginal discomfort, less ST segment shift (0.44 +/- 0.13 versus 0.21 +/- 0.07 mV, p = 0.01), and lower mean pulmonary artery pressure (25 +/- 1.0 versus 20 +/- 1.7 mm Hg, p = 0.005). In addition, for the same heart rate-blood pressure product, cardiac vein flow during the second inflation was significantly lower than that recorded during the first inflation (96 +/- 1.4 versus 83 +/- 2.4 ml/min, p = 0.005). Finally, there was significantly less myocardial lactate production during the sec...
Synchronous Gastric Neoplastic Lesions: Clinical analysis and Therapeutic Approach
Authors: M Rodríguez-Carrasco, D Libânio, P Pimentel-Nunes, LP Afonso, P Monterio, M Dinis-Ribeiro
Journal: Endoscopy (2021)

Aims Synchronous gastric neoplastic lesions have been reported in up to 10.9 % of patients with gastric cancer and the most adequate strategy (simultaneous resection vs deferment) is unclear since safety and outcomes of the two strategies have been rarely evaluated. We aimed to analyse the prevalence of gastric synchronous lesions, possible risk factors for its diagnosis, and outcomes of simultaneous resection.
New catheter technique for recording left free-wall accessory atrioventricular pathway activation. Identification of pathway fiber orientation.
Authors: W MJackman, K JFriday, J AYeung-Lai-Wah, D MFitzgerald, BBeck, A JBowman, PStelzer, LHarrison, RLazzara
Journal: Circulation (1988)

The ability to record accessory atrioventricular (AV) pathway activation consistently may be uniquely beneficial in improving pathway localization, identifying anatomic relations, and providing insight into unusual conduction properties. For the purpose of recording left AV accessory pathway activation, an electrode catheter was specially designed for use in the coronary sinus. The orthogonal catheter has three sets of four electrodes spaced evenly around the circumference. Electrograms were recorded at low gain (less than 1 cm/mV) between adjacent electrodes on the same set (interelectrode distance, 1.5 mm, center to center). This provides a recording dipole perpendicular to the atrioventricular groove to enhance recording of accessory pathway activation while minimizing overlapping atrial or ventricular potentials. The orthogonal electrode catheter was used in the electrophysiological study of 48 consecutive patients with 59 left AV accessory pathways. The catheter could be advanced along the coronary s...
Long-term hemodynamic follow-up of cardiac transplant patients treated with cyclosporine and prednisone.
Authors: M LGreenberg, B FUretsky, P SReddy, R LBernstein, B PGriffith, R LHardesty, M EThompson, H TBahnson
Journal: Circulation (1985)

To evaluate the long-term hemodynamic results in cardiac transplant patients treated with cyclosporine and prednisone, 19 patients were studied by cardiac catheterization and endomyocardial biopsy 13 +/- 3 months after transplantation. Immunosuppression consisted of 6 +/- 4 mg/kg/day cyclosporine and 20 +/- 8 mg/day prednisone. Eighteen patients were asymptomatic but had developed postoperative systemic hypertension (17 on antihypertensive therapy). These patients were compared with a normotensive control group of 18 patients without cardiovascular disease. Significant differences were found in heart rate; right atrial, pulmonary arterial, pulmonary arterial wedge, systemic arterial, and left ventricular end-diastolic pressures; cardiac index and stroke volume index; systemic and pulmonary vascular resistance; and end-diastolic volume index and left ventricular ejection fraction. The most frequent hemodynamic abnormalities included an elevated arterial pressure in 10 patients (56%), an elevated left ventr...
Regional differences in the in vivo synthesis and degradation of myosin subunits in rabbit ventricular myocardium.
Authors: A MSamarel
Journal: Circulation Research (1989)

To test for regional differences in the rates of synthesis and degradation of contractile proteins during normal physiological growth of the heart in vivo, fractional rates of protein accumulation and synthesis were assessed for total protein, myosin heavy chain, myosin light chain, phosphorylatable myosin light chain, and actin in the right and left ventricular free walls of growing, New Zealand White rabbits. Fractional rates of protein accumulation were determined from regional protein content growth curves of total and individual myofibrillar proteins measured in 82 animals ranging from 1 day to 9 weeks of age. In vivo right and left ventricular fractional rates of protein synthesis were determined by the [3H]leucine constant infusion method in 9-week-old rabbits. At this age, right and left ventricular fractional accumulation rates for total protein, myosin subunits, and actin were found to be identical, thus allowing for the comparison of the effect of regional hemodynamic load on protein degradatio...
Selecting the Optimal Design for Drug Discontinuation Trials in a Setting of Advanced, Life-Limiting Illness
Authors: Eric C. T. Geijteman, Henning Tiemeier, Teun van Gelder
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Monitoring the proportion of the population infected by SARS-CoV-2 using age-stratified hospitalisation and serological data: a modelling study
Authors: Nathanaël Hozé, Juliette Paireau, Nathanaël Lapidus, Cécile Tran Kiem, Henrik Salje, Gianluca Severi, Mathilde Touvier, Marie Zins, Xavier de Lamballerie, Daniel Lévy-Bruhl, Fabrice Carrat, Simon Cauchemez
Journal: The Lancet Public Health (2021)

Regional monitoring of the proportion of the population who have been infected by SARS-CoV-2 is important to guide local management of the epidemic, but is difficult in the absence of regular nationwide serosurveys. We aimed to estimate in near real time the proportion of adults who have been infected by SARS-CoV-2.In this modelling study, we developed a method to reconstruct the proportion of adults who have been infected by SARS-CoV-2 and the proportion of infections being detected, using the joint analysis of age-stratified seroprevalence, hospitalisation, and case data, with deconvolution methods. We developed our method on a dataset consisting of seroprevalence estimates from 9782 participants (aged ≥20 years) in the two worst affected regions of France in May, 2020, and applied our approach to the 13 French metropolitan regions over the period March, 2020, to January, 2021. We validated our method externally using data from a national seroprevalence study done between May and June, 2020.We estimate that 5·7% (95% CI 5·1-6·4) of adults in metropolitan France had been infected with SARS-CoV-2 by May 11, 2020. This proportion remained stable until August, 2020, and increased to 14·9% (13·2-16·9) by Jan 15, 2021. With 26·5% (23·4-29·8) of adult residents having been infected in Île-de-France (Paris region) compared with 5·1% (4·5-5·8) in Brittany by January, 2021, regional variations remained large (coefficient of variation [CV] 0·50) although less so than in May, 2020 (CV 0·74). The proportion infected was twice as high (20·4%, 15·6-26·3) in 20-49-year-olds than in individuals aged 50 years or older (9·7%, 6·9-14·1). 40·2% (34·3-46·3) of infections in adults were detected in June to August, 2020, compared with 49·3% (42·9-55·9) in November, 2020, to January, 2021. Our regional estimates of seroprevalence were strongly correlated with the external validation dataset (coefficient of correlation 0·89).Our simple approach to estimate the proportion of adults that have been infected with SARS-CoV-2 can help to characterise the burden of SARS-CoV-2 infection, epidemic dynamics, and the performance of surveillance in different regions.EU RECOVER, Agence Nationale de la Recherche, Fondation pour la Recherche Médicale, Institut National de la Santé et de la Recherche Médicale (Inserm).
Dynamic nature of the aortic regurgitant orifice area during diastole in patients with chronic aortic regurgitation.
Authors: S CReimold, S EMaier, K EFleischmann, MKhatri, DPiwnica-Worms, RKikinis, R TLee
Journal: Circulation (1994)

BACKGROUNDThe effective aortic regurgitant orifice area varies with aortic pressure in animal models of acute aortic regurgitation. The purpose of this study was to determine whether the aortic regurgitant orifice area changes during diastole in patients with chronic aortic regurgitation.METHODS AND RESULTSTwo-dimensional and Doppler echocardiography were performed immediately before and after magnetic resonance velocity mapping using a cine phase contrast sequence in 17 patients with chronic aortic regurgitation. ECG-gated continuous-wave Doppler velocity time integrals and magnetic resonance flow rates were measured 16 times per cardiac cycle. The mean aortic regurgitant orifice area (centimeters squared) was calculated by the continuity equation. The regurgitant orifice area was also determined for each diastolic acquisition interval. Changes in the regurgitant orifice area during diastole were modeled using an asymptotic exponential decay model to determine the static and dynamic components of the ori...
Typical Gastroesophageal Reflux Disease in a General Population: Epidemiological, Clinical and Endoscopic Profile
Authors: R Harbi, K Ben Abdesselem, A Hammami, W Dahmani, W Ben Ameur, N Elleuch, S Ajmi, A Brahem, A Ben Slama, M Ksiaa, H Jaziri, A Jmaa
Journal: Endoscopy (2021)

Aims Gastroesophageal reflux disease (GERD) represents a public health problem because of its prevalence and its impact on the quality of life of patients. Esophagitis represents one of its main complications. The aim of the work is to describe the epidemiological, clinical and endoscopic lesions of gastroesophageal reflux disease.
Blood leukocytes recapitulate diabetogenic peptide–MHC-II complexes displayed in the pancreatic islets
Authors: Anthony N. Vomund, Cheryl F. Lichti, Orion J. Peterson, Ana Maria Arbelaez, Xiaoxiao Wan, Emil R. Unanue
Journal: The Journal of Experimental Medicine (2021)

Assessing the self-peptides presented by susceptible major histocompatibility complex (MHC) molecules is crucial for evaluating the pathogenesis and therapeutics of tissue-specific autoimmune diseases. However, direct examination of such MHC-bound peptides displayed in the target organ remains largely impractical. Here, we demonstrate that the blood leukocytes from the nonobese diabetic (NOD) mice presented peptide epitopes to autoreactive CD4 T cells. These peptides were bound to the autoimmune class II MHC molecule (MHC-II) I-Ag7 and originated from insulin B-chain and C-peptide. The presentation required a glucose challenge, which stimulated the release of the insulin peptides from the pancreatic islets. The circulating leukocytes, especially the B cells, promptly captured and presented these peptides. Mass spectrometry analysis of the leukocyte MHC-II peptidome revealed a series of β cell-derived peptides, with identical sequences to those previously identified in the islet MHC-II peptidome. Thus, the blood leukocyte peptidome echoes that found in islets and serves to identify immunogenic peptides in an otherwise inaccessible tissue.
Acute effects of low doses of alcohol on left ventricular function by echocardiography.
Authors: C EDelgado, N JGortuin, R SRoss
Journal: Circulation (1975)

The ultrasound method for measuring the dimensions of the left ventricle was utilized to study the effect of oral doses of alcohol on left ventricular function in normal volunteers. Systolic time intervals were also measured. Seven subjects received 0.7 g/kg of ethanol (group I) and six subjects recieved 1.15 g/kg (group II). The peak of blood alcohol levels in the two groups were 75 mg/100 ml and 138 mg/100 ml respectively. There was a 6% decrease in the fractional change in the minor axis of the left ventricle in group I patients which resulted in a decrease in ejection fraction (p greater than 0.05). In group II patients, there was a 3% decrease in the fractional change in the minor axis of the left ventricle, but the change of ejection fraction was not significant. Since there was no significant difference between the physiological effects observed in groups I and II, the two groups were combined. In the combined group, at 30 minutes after the ingestion of alchol, the heart rate was increased by 11%, ...
Gut bacteriophage dynamics during fecal microbial transplantation in subjects with metabolic syndrome
Authors: Pilar Manrique, Yifan Zhu, John van der Oost, Hilde Herrema, Max Nieuwdorp, Willem M. de Vos, Mark Young
Journal: Gut Microbes (2021)

Metabolic Syndrome (MetS) is a growing public health concern worldwide. Individuals with MetS have an increased risk for cardiovascular (CV) disease and type 2 diabetes (T2D). These diseases - in part preventable with the treatment of MetS - increase the chances of premature death and pose a great economic burden to health systems. A healthy gut microbiota is associated with a reduction in MetS, T2D, and CV disease. Treatment of MetS with fecal microbiota transplantation (FMT) can be effective, however, its success rate is intermediate and difficult to predict. Because bacteriophages significantly affect the microbiota membership and function, the aim of this pilot study was to explore the dynamics of the gut bacteriophage community after FMT in MetS subjects. We performed a longitudinal study of stool bacteriophages from healthy donors and MetS subjects before and after FMT treatment. Subjects were assigned to either a control group (self-stool transplant, n = 3) or a treatment group (healthy-donor-stool transplant; n-recipients = 6, n-donors = 5). Stool samples were collected over an 18-week period and bacteriophage-like particles were purified and sequenced. We found that FMT from healthy donors significantly alters the gut bacteriophage community. Subjects with better clinical outcome clustered closer to the heathy donor group, suggesting that throughout the treatment, their bacteriophage community was more similar to healthy donors. Finally, we identified bacteriophage groups that could explain these differences and we examined their prevalence in individuals from a larger cohort of MetS FMT trial.Trial information- http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=2705; NTR 2705.
Truncus arteriosus with unilateral absence of a pulmonary artery. Criteria for operability and surgical results.
Authors: D DMair, D GRitter, G KDanielson, R BWallace, D CMcGoon
Journal: Circulation (1977)

In 15 of 126 (12%) patients with truncus arteriosus who were catheterized at the Mayo Clinic from 1967 through 1975, natural agenesis of one pulmonary artery was present. Ten truncus patients with either natural or acquired absence of one pulmonary artery have undergone definitive operation. The criteria for operability, based on a calculation of pulmonary resistance, are different in patients with single pulmonary artery than in patients with two pulmonary arteries. Study revealed that, if the calculated pulmonary resistance in the patient with single pulmonary artery is halved, this new value provides a more reliable assessment of the reactivity of the pulmonary arteriolar bed than does the total calculated pulmonary resistance value. Follow-up information suggests that the patient with single pulmonary artery may be at potentially high risk of continued progression of pulmonary vascular disease after surgical correction, possibly because of the postoperative obligatory increased flow through the single...
Single-Session Eus-Guided Duodenojejunostomy And Through-The-Lams ERCP Combined With Eus-Guided Gallbladder DrainagE (EUS-GBD) in ROUX-EN-Y GASTRECTOMY
Authors: E Fuentes-Valenzuela, R Sánchez-Ocaña, C Chavarría, C De la Serna Higuera, M Pérez-Miranda
Journal: Endoscopy (2021)

An 88-yo subtotal gastrectomy female experienced cholecystitis with CBD stones. ERCP failed and lack of intrahepatic dilatation prevented antegrade EUS-guided stone removal. EUS-guided transportal-cholangiography with 22G-needle confirmed CBD stones. Contrast outflow into the duodenum facilitated afferent limb location and free-hand placement of a duodenojejunal cautery-enhanced 20-mm lumen-apposing metal stent (LAMS). Using a duodenoscope, a through-the-LAMS ERCP with CBD stone removal was performed. Lastly, echoendoscope passage through-the-LAMS allowed retrograde access to the duodenal bulb and free-hand insertion of a 10-mm LAMS for cholecystoduodenostomy. EUS-guided transportal-cholangiography with transenteric LAMS allow combined ERCP and EUS-GBD in a single-session in nonoperative Roux-en-Y gastrectomy patients.
George Lyman Duff Memorial Lecture. Lifestyles, major risk factors, proof and public policy.
Authors: JStamler
Journal: Circulation (1978)

In this report major risk factors in coronary heart disease (CHD) are reviewed, with particular emphasis on the role of nutrition. International and national epidemiologic data indicate that reducing or eliminating certain risk factors (e.g., a diet high in cholesterol and saturated fats) may reduce the risk of premature CHD. Most trends indicate that many Americans are more concerned about diet for health reasons. Preventive measures for CHD are also discussed.
Vascular responses to leukocyte products in atherosclerotic primates.
Authors: J ALopez, M LArmstrong, D GHarrison, D JPiegors, D DHeistad
Journal: Circulation Research (1989)

Little is known about the possible role of leukocytes in the pathogenesis of vasospasm. We hypothesized that vasoactive products released by leukocytes might produce constriction of atherosclerotic arteries. To test this hypothesis, we infused fmet-leu-phe (fMLP), a peptide that activates leukocytes to release their vasoactive products, into the perfused hind limb of normal and atherosclerotic cynomolgus monkeys. Infusion of fMLP did not change resistance of large arteries in normal monkeys. In contrast, fMLP produced pronounced constriction of large arteries in atherosclerotic monkeys. To determine whether leukotrienes, platelet-activating factor, or prostaglandin E2 (PGE2), which are released by leukocytes, may contribute to leukocyte-induced vasoconstriction in atherosclerotic monkeys, we injected leukotriene D4, platelet-activating factor, and PGE2 intra-arterially into the perfused hind limb. Leukotriene D4 and platelet-activating factor had minimal effects on large arteries in both normal and athero...
Ruptured atheromatous plaques in saphenous vein coronary artery bypass grafts: a mechanism of acute, thrombotic, late graft occlusion.
Authors: A EWalts, M CFishbein, HSustaita, J MMatloff
Journal: Circulation (1982)

Although early occlusion of saphenous vein coronary artery bypass grafts is usually thrombotic, late occlusion is most often a result of progressive intimal fibromuscular proliferation or atheroma formation in the implanted vain. We describe another mechanism of late graft occlusion: atheromatous plaque rupture with superimposed occlusive thrombosis. Four men, ages 48-67 years underwent repeat bypass surgery for recurrent angina. Six of eight vein grafts excised 5-8 years after original bypass showed complete luminal occlusion by recent thrombus superimposed on ruptured atheromatous plaques. Similar findings were present at autopsy in two of three vein grafts from a 66-year-old man who died 7 years after bypass. These lesions are indistinguishable from those that occur in native coronary arteries of many patients with acute myocardial infarction. Unlike previously described graft occlusions, the present lesion represents a mechanism of acute, thrombotic, late graft occlusion. If recognized early, it may b...