tbuckley/cabot-search huggingface dataset:
Two subsets of human marginal zone B cells resolved by global analysis of lymphoid tissues and blood
Authors: Jacqueline H.Y. Siu, Michael J. Pitcher, Thomas J. Tull, Rebekah L. Velounias, William Guesdon, Lucia Montorsi, Krishnaa T. Mahbubani, Richard Ellis, Pawan Dhami, Katrina Todd, Ulrich D. Kadolsky, Michelle Kleeman, David P. D’Cruz, Kourosh Saeb-Parsy, Mats Bemark, Gavin J. Pettigrew, Jo Spencer
Journal: Science Immunology (2022)

B cells generate antibodies that are essential for immune protection, but their subgroups are poorly defined. Here, we perform undirected deep profiling of B cells in matched human lymphoid tissues from deceased transplant organ donors and blood. In addition to identifying unanticipated features of tissue-based B cell differentiation, we resolve two subsets of marginal zone B (MZB) cells differing in cell surface and transcriptomic profiles, clonal relationships to other subsets, enrichment of genes in the NOTCH pathway, distribution bias within splenic marginal zone microenvironment, and immunoglobulin repertoire diversity and hypermutation frequency. Each subset is present in spleen, gut-associated lymphoid tissue, mesenteric lymph nodes, and blood. MZB cells and the lineage from which they are derived are depleted in lupus nephritis. Here, we show that this depletion is of only one MZB subset. The other remains unchanged as a proportion of total B cells compared with health. Thus, it is important to factor MZB cell heterogeneity into studies of human B cell responses and pathology.
LONG TERM OUTCOMES FOLLOWING THE USE OF FRACTIONAL FLOW RESERVE TO ASSESS CORONARY ARTERY DISEASE IN PATIENTS WITH SEVERE AORTIC STENOSIS UNDERGOING TRANSCATHETER AORTIC VALVE IMPLANTATION
Authors: Juva Benseba, Josep Rodés-Cabau, Jonathan Beaudoin, Sandra Hadjadj, Dimitri Kalavrouziotis, Eric Dumont, Siamak Mohammadi, Jules Mesnier, Vassili Panagides, Melanie Cote, Thomas Couture, Julien Mercier, Laurent Faroux, Laurence Bernatchez, DeLarochellière Robert, Jean-Michel Paradis
Journal: Journal of the American College of Cardiology (2022)
PRASUGREL DE-ESCALATION THERAPY IN ACUTE CORONARY SYNDROME WITH DIABETES MELLITUS: HOST-REDUCE-POLYTECH-ACS DM SUBGROUP ANALYSIS
Authors: Kyu-Sun Lee, Kyung Woo Park, Doyeon Hwang, Jeehoon Kang, Jung-kyu Han, Han-Mo Yang, Hyun-Jae Kang, Bon Kwon Koo, Jay Young Rhew, Kook-Jin Chun, Young-Hyo Lim, Jang-Whan Bae, Bon Ki Lee, Seok Yeon Kim, Namho Lee, Hyo-Soo Kim
Journal: Journal of the American College of Cardiology (2022)
Diagnosis and Management of Acute Appendicitis—Reply
Authors: Dimitrios Moris, Erik Karl Paulson, Theodore N. Pappas
Journal: JAMA (2022)

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Prevalence of Firearm Ownership Among Individuals With Major Depressive Symptoms
Authors: Roy H. Perlis, Matthew D. Simonson, Jon Green, Jennifer Lin, Alauna Safarpour, Kristin Lunz Trujillo, Alexi Quintana, Hanyu Chwe, John Della Volpe, Katherine Ognyanova, Mauricio Santillana, James Druckman, David Lazer, Matthew A. Baum
Journal: JAMA Network Open (2022)

Both major depression and firearm ownership are associated with an increased risk for death by suicide in the United States, but the extent of overlap among these major risk factors is not well characterized.To assess the prevalence of current and planned firearm ownership among individuals with depression.Cross-sectional survey study using data pooled from 2 waves of a 50-state nonprobability internet survey conducted between May and July 7, 2021. Internet survey respondents were 18 years of age or older and were sampled from all 50 US states and the District of Columbia.Self-reported firearm ownership; depressive symptoms as measured by the 9-item Patient Health Questionnaire.Of 24 770 survey respondents (64.6% women and 35.4% men; 5.0% Asian, 10.8% Black, 7.5% Hispanic, and 74.0% White; mean [SD] age 45.8 [17.5]), 6929 (28.0%) reported moderate or greater depressive symptoms; this group had mean (SD) age of 38.18 (15.19) years, 4587 were female (66.2%), and 406 were Asian (5.9%), 725 were Black (10.5%), 652 were Hispanic (6.8%), and 4902 were White (70.7%). Of those with depression, 31.3% reported firearm ownership (n = 2167), of whom 35.9% (n = 777) reported purchasing a firearm within the past year. In regression models, the presence of moderate or greater depressive symptoms was not significantly associated with firearm ownership (adjusted odds ratio [OR], 1.07; 95% CI, 0.98-1.17) but was associated with greater likelihood of a first-time firearm purchase during the COVID-19 pandemic (adjusted OR, 1.77; 95% CI, 1.56-2.02) and greater likelihood of considering a future firearm purchase (adjusted OR, 1.53; 95% CI, 1.23-1.90).In this study, current and planned firearm ownership was common among individuals with major depressive symptoms, suggesting a public health opportunity to address this conjunction of suicide risk factors.
DECISION-MAKING IN AORTIC ARCH REPLACEMENT IN MARFAN SYNDROME: REDO BENTALL OPERATION WITH FROZEN ELEPHANT TRUNK E-VITA OPEN NEO HYBRID PROSTHESIS. FIRST-INMAN IMPLANTATION IN VENEZUELA
Authors: George De Santolo, Marianela Reinaga, Herman Rodríguez, Chadi Nasser, Gaston Silva, Giambattista La Forgia, Isaubett Yajure, Herde Jose, Carlos balliache, Carlos D. Calderas, Luanne Piamo, Hildamari atienza, Yoly Tarache
Journal: Journal of the American College of Cardiology (2022)
FAILURE OR FLARE? CARDIOGENIC SHOCK IN A PATIENT WITH IMMUNE CHECKPOINT INHIBITOR-ASSOCIATED MYOCARDITIS AND CHRONIC HEART FAILURE (HF)
Authors: David Madnick, Maani Kamal, Tarek Zghaib, Chris Domenico, Joseph Carver, Benedicte Lefebvre, Joyce Wald, Nosheen Reza
Journal: Journal of the American College of Cardiology (2022)
30-DAY TRANSCATHETER AORTIC VALVE REPLACEMENT OUTCOMES AMONG HEART FAILURE EJECTION FRACTION SUB-PHENOTYPES
Authors: Julia Huang, Mark Brahier, Shwetha Kochi, Athanasios Thomaides, Ron Waksman, Lowell F. Satler, Peter J. Bergquist, Monvadi B. Srichai, Jose D. Vargas
Journal: Journal of the American College of Cardiology (2022)
Systematic reconstruction of cellular trajectories across mouse embryogenesis
Authors: Chengxiang Qiu, Junyue Cao, Beth K. Martin, Tony Li, Ian C. Welsh, Sanjay Srivatsan, Xingfan Huang, Diego Calderon, William Stafford Noble, Christine M. Disteche, Stephen A. Murray, Malte Spielmann, Cecilia B. Moens, Cole Trapnell, Jay Shendure
Journal: Nature Genetics (2022)

Mammalian embryogenesis is characterized by rapid cellular proliferation and diversification. Within a few weeks, a single-cell zygote gives rise to millions of cells expressing a panoply of molecular programs. Although intensively studied, a comprehensive delineation of the major cellular trajectories that comprise mammalian development in vivo remains elusive. Here, we set out to integrate several single-cell RNA-sequencing (scRNA-seq) datasets that collectively span mouse gastrulation and organogenesis, supplemented with new profiling of ~150,000 nuclei from approximately embryonic day 8.5 (E8.5) embryos staged in one-somite increments. Overall, we define cell states at each of 19 successive stages spanning E3.5 to E13.5 and heuristically connect them to their pseudoancestors and pseudodescendants. Although constructed through automated procedures, the resulting directed acyclic graph (TOME (trajectories of mammalian embryogenesis)) is largely consistent with our contemporary understanding of mammalian development. We leverage TOME to systematically nominate transcription factors (TFs) as candidate regulators of each cell type's specification, as well as 'cell-type homologs' across vertebrate evolution.
SEVERE SUBAORTIC STENOSIS ASSOCIATED TO PATENT DUCTUS ARTERIOSUS IN A YOUNG ADULT PATIENT: WHAT GOES FIRST?
Authors: Axel Hiram Hernandez-Pineda, Imelda Rincon-Gomez, Nelly Rojas-Jacome, Israel Garcia-Davalos, Diana Lopez-Gallegos, Lucelli Yañez-Gutierrez, Jaime Alfonso Santiago-Hernandez
Journal: Journal of the American College of Cardiology (2022)
BALLOON ASSISTED VALVULOPLASTY FOLLOWED BY IMPELLA PLACEMENT FOR HIGH-RISK PERCUTANEOUS CORONARY INTERVENTION IS FEASIBLE AND SAFE IN NONEMERGENT CASES
Authors: Johanna Ben-Ami, Mahesh Madhavan, Erin Flattery, Tamim Nazif, Jeffrey W. Moses, Megha Prasad
Journal: Journal of the American College of Cardiology (2022)
Gut commensal <i>Limosilactobacillus reuteri</i> induces atypical memory-like phenotype in human dendritic cells in vitro
Authors: Gintare Lasaviciute, Myriam Barz, Marieke van der Heiden, Claudia Arasa, Kanwal Tariq, Jaclyn Quin, Ann-Kristin Östlund Farrants, Eva Sverremark-Ekström
Journal: Gut Microbes (2022)

Memory-like responses in innate immune cells confer nonspecific protection against secondary exposures. A number of microbial agents have been found to induce enhanced or diminished recall responses in innate cells, however, studies investigating the ability of probiotic bacteria to trigger such effects are lacking. Here, we show that priming of human monocytes with a secretome from the gut probiotic bacterium Limosilactobacillus (L.) reuteri induces a mixed secondary response phenotype in monocyte-derived dendritic cells (mo-DCs), with a strong IL-6 and IL-1β response but low TNFα, IL-23 and IL-27 secretion. Instead, blood DC priming with L. reuteri-secretome resembles a tolerant state upon secondary exposure. A similar pattern was found in conventional and gut-like (retinoic acid exposed) DCs, although retinoic acid hampered TNFα and IL-6 production and enrichment of histone modifications in L. reuteri-secretome primed mo-DC cultures. Further, we show that the memory-like phenotype of mo-DCs, induced by priming stimuli, is important for subsequent T helper (Th) cell differentiation pathways and might determine the inflammatory nature of Th cells. We also show enhanced recall responses characterized by robust inflammatory cytokines and lactate production in the gut-like mo-DCs derived from β-glucan primed monocytes. Such responses were accompanied with enriched histone modifications at the promoter of genes associated with a trained phenotype in myeloid cells. Altogether, we demonstrate that a gut commensal-derived secretome prompts recall responses in human DCs which differ from that induced by classical training agents such as β-glucan. Our results could be beneficial for future therapeutic interventions where T cell responses are needed to be modulated.
Alzheimer’s disease – the journey of a healthy brain into organ failure
Authors: Todd E. Golde
Journal: Molecular Neurodegeneration (2022)

As the most common dementia, Alzheimer's disease (AD) exacts an immense personal, societal, and economic toll. AD was first described at the neuropathological level in the early 1900s. Today, we have mechanistic insight into select aspects of AD pathogenesis and have the ability to clinically detect and diagnose AD and underlying AD pathologies in living patients. These insights demonstrate that AD is a complex, insidious, degenerative proteinopathy triggered by Aβ aggregate formation. Over time Aβ pathology drives neurofibrillary tangle (NFT) pathology, dysfunction of virtually all cell types in the brain, and ultimately, overt neurodegeneration. Yet, large gaps in our knowledge of AD pathophysiology and huge unmet medical need remain. Though we largely conceptualize AD as a disease of aging, heritable and non-heritable factors impact brain physiology, either continuously or at specific time points during the lifespan, and thereby alter risk for devolvement of AD. Herein, I describe the lifelong journey of a healthy brain from birth to death with AD, while acknowledging the many knowledge gaps that remain regarding our understanding of AD pathogenesis. To ensure the current lexicon surrounding AD changes from inevitable, incurable, and poorly manageable to a lexicon of preventable, curable, and manageable we must address these knowledge gaps, develop therapies that have a bigger impact on clinical symptoms or progression of disease and use these interventions at the appropriate stage of disease.
RARE CASE OF PURULENT PERICARDITIS
Authors: Krishna Pabba, Jordan Potter, Ali-Reza Ghergherehchi, Jonathan P. Urbanczyk, Michael Engheta, Adesola Adenegan, Kevin Kurian, Mary Lee, Bryce Rhodehouse, Travis W. Haneke, Michael Sumner, Yissela Analy Escobedo, Sarah Payne, Jerry Fan, Christopher Perez, Raveen Chawla, Todd Thomas, Robert Jay Widmer, Timothy A. Mixon, Christopher McCoy, Christopher D. Chiles, Steven Manuel Costa
Journal: Journal of the American College of Cardiology (2022)
Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity
Authors: Rosa Barreira da Silva, Ricardo M. Leitao, Ximo Pechuan-Jorge, Scott Werneke, Jason Oeh, Vincent Javinal, Yingyun Wang, Wilson Phung, Christine Everett, Jim Nonomiya, David Arnott, Cheng Lu, Yi-Chun Hsiao, James T. Koerber, Isidro Hötzel, James Ziai, Zora Modrusan, Thomas H. Pillow, Merone Roose-Girma, Jill M. Schartner, Mark Merchant, Sascha Rutz, Céline Eidenschenk, Ira Mellman, Matthew L. Albert
Journal: Nature Immunology (2022)
Industry influence over global alcohol policies via the World Trade Organization: a qualitative analysis of discussions on alcohol health warning labelling, 2010–19
Authors: Pepita Barlow, Deborah Gleeson, Paula O'Brien, Ronald Labonte
Journal: The Lancet Global Health (2022)

BackgroundAccelerating progress to implement effective alcohol policies is necessary to achieve multiple targets within the WHO global strategy to reduce the harmful use of alcohol and the Sustainable Development Goals. However, the alcohol industry's role in shaping alcohol policy through international avenues, such as trade fora, is poorly understood. We investigate whether the World Trade Organization (WTO) is a forum for alcohol industry influence over alcohol policy.MethodsIn this qualitative analysis, we studied discussions on alcohol health warning labelling policies that occurred at the WTO's Technical Barriers to Trade (TBT) Committee meetings. Using the WTO Documents Online archive, we searched the written minutes of all TBT Committee meetings available from Jan 1, 1995, to Dec 31, 2019, to identify minutes and referenced documents pertaining to discussions on health warning labelling policies. We specifically sought WTO member statements on health warning labelling policies. We identified instances in which WTO member representatives indicated that their statements represented industry. We further developed and applied a taxonomy of industry rhetoric to identify whether WTO member statements advanced arguments made by industry in domestic forums.FindingsAmong 83 documents, comprising TBT Committee minutes, notifications to the WTO of the policy proposal, and written comments by WTO members, WTO members made 212 statements (between March 24, 2010, and Nov 15, 2019) on ten alcohol labelling policies proposed by Thailand, Kenya, the Dominican Republic, Israel, Turkey, Mexico, India, South Africa, Ireland, and South Korea. WTO members stated that their claims represented industry in seven (3·3%) of 212 statements, and 117 (55·2%) statements featured industry arguments. Member statements featured many arguments used by industry in domestic policy forums to stall alcohol policy. Arguments focused on descaling and reframing the nature and causes of alcohol-related problems, promoting alternative policies such as information campaigns, promoting industry partnerships, questioning the evidence, and emphasising manufacturing and wider economic costs and harms.InterpretationWTO discussions at TBT Committee meetings on alcohol health warnings advanced arguments used by the alcohol industry in domestic settings to prevent potentially effective alcohol policies. WTO members appeared to be influenced by alcohol industry interests, although only a minority of challenges explicitly referenced industry demands. Increased transparency about vested interests might be needed to overcome industry influence.FundingNone.
Abstract P4-06-04: The role of axillary lymph node status in residual cancer burden calculation of triple negative breast cancer post-neoadjuvant cytotoxic chemotherapy
Authors: Shipra Gandhi, Kristopher Attwood, Wenyan Ji, Saif Aljabab, Thaer Khoury
Journal: Cancer Research (2022)

Abstract BACKGROUND: The residual cancer burden (RCB) is calculated utilizing these variables: tumor bed size, tumor/tumor bed ratio, percentage of DCIS, number of positive lymph nodes (LN) and the size of the largest LN. The aim of the study is to investigate if other variables related to the LNs correlate with the outcomes. METHODS: We conducted pathologic review of 129 patients who had triple negative breast cancer (TNBC) diagnosed between 2002 and 2006. The following variables were calculated, Finv: primary tumor/tumor bed ratio; dmet: diameter of largest involved LN; dprim= √d1d2 (d1 and d2 dimensions of the primary tumor bed); RCBprim = finv dprim ; RCBmet = 4 (1- 0.75LN) dmet; and RCB = 1.4 (finvdprim)0.17 + [4(1- 0.75 LN) dmet ]0.17. We calculated the LN tumor/tumor bed ratio (fLN), the number of resected LNs, and the number of LNs with therapy effect (with or without metastases). Clinical staging was abstracted from the medical records. Clinicopathologic variables were correlated with the recurrence free survival (RFS) and overall survival (OS). RESULTS: Most of the patients were treated with anthracycline based chemotherapy (CT) (90.7%). The median and range of follow up was 108.2 (15.0, 225.1) months. Pathology complete response (pCR) was achieved in 34.1% of the patients and correlated with age (p= 0.042) and clinical stage (p=0.004). pCR had better survival after 5-years (p&amp;lt;0.001) and 10 years (p=0.001) follow up. In the univariate analysis the following variables were statistically significant correlating with RFS and OS including clinical stage, RCB, and fLN. These variables were statistically significant in the multivariate analysis for RFS including clinical stage with hazard ratio (HR) 0.37 (0.15, 0.89) (p=0.026) and fLN HR 1.01 (1.00, 1.02) (p=0.006); and for OS with HR 0.35 (0.14, 0.85) (p=0.02) and 1.01 (1.00, 1.02) (p=0.01), respectively. CONCLUSIONS: Adding LN tumor/tumor bed ratio (fLN) to the existing formula may improve the predictability power of the RCB index. Citation Format: Shipra Gandhi, Kristopher Attwood, Wenyan Ji, Saif Aljabab, Thaer Khoury. The role of axillary lymph node status in residual cancer burden calculation of triple negative breast cancer post-neoadjuvant cytotoxic chemotherapy [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P4-06-04.
MEDICATION ADHERENCE ASSOCIATED WITH AREA-LEVEL SOCIAL RISK EXPOSURE AMONG PATIENTS WITH VENOUS THROMBOEMBOLISM: A NATIONAL RETROSPECTIVE COHORT STUDY
Authors: Carmine Colavecchia, Lisa Boyd, Kevin Townsend, Laura Kmitch, Leah Broder, Rozelle Hegeman-Dingle, Mohammad Ateya, Jose Alvir
Journal: Journal of the American College of Cardiology (2022)
SHORT VERSUS STANDARD DURATION OF DUAL ANTIPLATELET THERAPY AFTER PERCUTANEOUS CORONARY INTERVENTION: AN UPDATED META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS IN ALL-COMERS
Authors: Amit Rout, Udaya Tantry, Abigail Chan, Vikas Singh, Paul A. Gurbel, Aakash Garg
Journal: Journal of the American College of Cardiology (2022)
Cholangioscopic appearance of circular folds in immune-related adverse event cholangitis
Authors: Ko Tomishima, Shigeto Ishii, Toshio Fujisawa, Satoshi Sakuma, Yusuke Takasaki, Koichi Ito, Hiroyuki Isayama
Journal: Endoscopy (2022)

Immune checkpoint inhibitors (ICIs) are increasingly being used for various indications in cancer. However, because they affect the immune system, their use may lead to immune-related adverse events (IRAEs). The use of nivolumab is associated with the IRAE cholangitis, which has no established countermeasures [1]. The cholangioscopic findings of cholangitis are nonspecific and include erosion, ulceration, and hemorrhage [2] [3]. We report a case of cholangitis showing circular folds on cholangioscopy.
Snake Envenomation
Authors: Steven A. Seifert, James O. Armitage, Elda E. Sanchez
Journal: New England Journal of Medicine (2022)

Snake envenomation is a global health problem. The range of clinical sequelae includes thromboses and neuromuscular paralysis. Antivenoms made in horses and sheep are the treatments of choice but require accurate identification of the bite source and can cause anaphylaxis and serum sickness.
BPI22-024: Assessing the Adherence to Standard of Care With Durvalumab and Overcoming Barriers in the Treatment of Unresectable Stage III Non-Small Cell Lung Cancer: A Single Institution Retrospective Study
Authors: Madhulika Urella, Jai Kumar Khatri, Anwar Khurram, Vivek Yadala, Adarsh Sidda, Noman Jang Khan, Maria Tria Tirona
Journal: Journal of the National Comprehensive Cancer Network (2022)

"BPI22-024: Assessing the Adherence to Standard of Care With Durvalumab and Overcoming Barriers in the Treatment of Unresectable Stage III Non-Small Cell Lung Cancer: A Single Institution Retrospective Study" published on 31 Mar 2022 by National Comprehensive Cancer Network.