tbuckley/cabot-search huggingface dataset:
Maternal gut microbiome regulates immunity to RSV infection in offspring
Authors: Wendy Fonseca, Carrie-Anne Malinczak, Kei Fujimura, Danny Li, Kathryn McCauley, Jia Li, Shannon K.K. Best, Diana Zhu, Andrew J. Rasky, Christine C. Johnson, Jennifer Bermick, Edward M. Zoratti, Dennis Ownby, Susan V. Lynch, Nicholas W. Lukacs, Catherine Ptaschinski
Journal: The Journal of Experimental Medicine (2021)

Development of the immune system can be influenced by diverse extrinsic and intrinsic factors that influence the risk of disease. Severe early life respiratory syncytial virus (RSV) infection is associated with persistent immune alterations. Previously, our group had shown that adult mice orally supplemented with Lactobacillus johnsonii exhibited decreased airway immunopathology following RSV infection. Here, we demonstrate that offspring of mice supplemented with L. johnsonii exhibit reduced airway mucus and Th2 cell–mediated response to RSV infection. Maternal supplementation resulted in a consistent gut microbiome in mothers and their offspring. Importantly, supplemented maternal plasma and breastmilk, and offspring plasma, exhibited decreased inflammatory metabolites. Cross-fostering studies showed that prenatal Lactobacillus exposure led to decreased Th2 cytokines and lung inflammation following RSV infection, while postnatal Lactobacillus exposure diminished goblet cell hypertrophy and mucus production in the lung in response to airway infection. These studies demonstrate that Lactobacillus modulation of the maternal microbiome and associated metabolic reprogramming enhance airway protection against RSV in neonates.
Characterization of Rookie Season Injury and Illness and Career Longevity Among National Basketball Association Players
Authors: Chelsea L. Martin, Amelia J. H. Arundale, Stefan Kluzek, Tyler Ferguson, Gary S. Collins, Garrett S. Bullock
Journal: JAMA Network Open (2021)

<h3>Importance</h3> There is limited research investigating injury and illness among professional basketball players during their rookie season. By improving the understanding of injury incidence and risk specific to rookie players, sports medicine clinicians may be able to further individualize injury mitigation programs that address the unique needs of rookie players. <h3>Objective</h3> To compare incidence and rate ratio (RR) of injury and illness among professional National Basketball Association (NBA) players in their rookie season with veteran players and to explore the association of sustaining an injury rookie season with career longevity. <h3>Design, Setting, and Participants</h3> This retrospective cohort study used an online data repository and extracted publicly available data about NBA players between the 2007 and 2008 season to the 2018 and 2019 season. Available data for initial injury and all subsequent injuries were extracted during this time frame. <h3>Exposures</h3> Injury and illness based on injury status during the rookie season of professional NBA players. <h3>Main Outcomes and Measures</h3> Injury and illness incidence and RR. Association of injury during the rookie season with career longevity was assessed via Poisson regressions. <h3>Results</h3> Of the 12 basketball seasons analyzed, 904 NBA players were included (mean [SD] age, 24.6 [3.9] years; body mass index, 24.8 [1.8]). The injury and illness incidence for rookie players was 14.28 per 1000 athlete game exposures (AGEs). Among all body regions, ankle injuries had the greatest injury incidence among players injured during their rookie season (3.17 [95% CI, 3.15-3.19] per 1000 AGEs). Rookie athletes demonstrated higher RR compared with veterans across multiple regions of the body (ankle: 1.32; 95% CI, 1.12 to 1.52; foot/toe: 1.29; 95% CI, 0.97 to 1.61; shoulder/arm/elbow: 1.43; 95% CI, 1.10 to 1.77; head/neck: 1.21; 95% CI, 0.61 to 1.81; concussions: 2.39; 95% CI, 1.89 to 2.90; illness: 1.14; 95% CI, 0.87 to 1.40), and demonstrated a higher rate of initial injuries compared with veteran players (1.41; 95% CI, 1.29 to 1.53). Players who sustained an injury rookie season demonstrated an unadjusted decrease in total seasons played (–0.4 [95% CI, –0.5 to –0.3] log years;<i>P</i> &lt; .001), but this decrease was not observed within adjusted analysis (0.1 [95% CI, –0.1 to 0.2] log years;<i>P</i> = .36). <h3>Conclusions and Relevance</h3> In this study, rookie athletes demonstrated the highest injury incidence at the ankle and increased RR across multiple regions. These findings may reflect differences in preseason conditioning or load variables impacting rookie athletes and warrant further investigation. Future research is needed to determine the association of cumulative injury burden vs a singular injury event on career longevity.
1799TiP HGCSG2002: A prospective multicenter observational biomarker study of microbiome for nivolumab treatment in advanced esophageal cancer
Authors: S. Nakano, K. Harada, S. Yuki, R. Saito, K. Ito, T. Yamamura, Y. Kawamoto, K. Hatanaka, M. Yagisawa, K. Sawada, M. Dazai, Y. Tsuji, I. Yokota, N. Sakamoto, Y. Sakata, Y. Komatsu
Journal: Annals of Oncology (2021)
Abstract 10403: Vasopressin V2 Receptor Antagonist Tolvaptan is Effective in Heart Failure Patients With Reduced Cardiac Systolic Function
Authors: Satoshi Suzuki, Akiomi Yoshihisa, Takayoshi Yamaki, Koichi Sugimoto, Hiroyuki Kunii, Kazuhiko Nakazato, Yukihiko Abe, Tomiyoshi Saito, Takayuki Ohwada, Shu-ichi Saitoh, Isao Kubota, Yasuchika Takeishi
Journal: Circulation (2013)

Backgroud: Acute decompensated heart failure (ADHF) is a common and highly morbid cardiovascular disorder, and diuresis is a major therapy for the reduction of congestive symptoms. Most diuretics c...
1551P Efficacy of early phase trials for soft-tissue sarcoma patients: The Centre Léon Bérard and Gustave Roussy experience
Authors: E.F. Nassif, J-Y. Blay, R. Bahleda, A. Dufresne, B. Mehdi, I.L. Ray-Coquard, P. Pautier, A. Leary, A. Levy, C. Le Pechoux, C. Honoré, O. Mir, C. Massard, A. Le Cesne
Journal: Annals of Oncology (2021)
대한간학회지 제2차 춘계학술대회 초록집 : 간세포암의 폐전이에 대한 간동맥 색전술의 의의
Authors: 박찬원 ( Park Chan Won ), 김준환 ( Kim Jun Hwan ), 이동준 ( Lee Dong Jun ), 김기윤 ( Kim Gi Yun ), 도갑석 ( Do Gab Seog ), 서정일 ( Seo Jeong Il ), 이헌주 ( Lee Heon Ju )
Journal: Clinical and Molecular Hepatology (1996)
<i>APOE3</i> -Jacksonville (V236E) variant reduces self-aggregation and risk of dementia
Authors: Chia-Chen Liu, Melissa E. Murray, Xia Li, Na Zhao, Na Wang, Michael G. Heckman, Francis Shue, Yuka Martens, Yonghe Li, Ana-Caroline Raulin, Cassandra L. Rosenberg, Sydney V. Doss, Jing Zhao, Melissa C. Wren, Lin Jia, Yingxue Ren, Tadafumi C. Ikezu, Wenyan Lu, Yuan Fu, Thomas Caulfield, Zachary A. Trottier, Joshua Knight, Yixing Chen, Cynthia Linares, Xue Wang, Aishe Kurti, Yan W. Asmann, Zbigniew K. Wszolek, Glenn E. Smith, Prashanthi Vemuri, Kejal Kantarci, David S. Knopman, Val J. Lowe, Clifford R. Jack, Joseph E. Parisi, Tanis J. Ferman, Bradley F. Boeve, Neill R. Graff-Radford, Ronald C. Petersen, Steven G. Younkin, John D. Fryer, Hu Wang, Xianlin Han, Carl Frieden, Dennis W. Dickson, Owen A. Ross, Guojun Bu
Journal: Science Translational Medicine (2021)

Apolipoprotein E (APOE) genetic variants have been shown to modify Alzheimer’s disease (AD) risk. We previously identified an APOE3 variant (APOE3-V236E), named APOE3-Jacksonville (APOE3-Jac), associated with healthy brain aging and reduced risk for AD and dementia with Lewy bodies (DLB). Herein, we resolved the functional mechanism by which APOE3-Jac reduces APOE aggregation and enhances its lipidation in human brains, as well as in cellular and biochemical assays. Compared to APOE3, expression of APOE3-Jac in astrocytes increases several classes of lipids in the brain including phosphatidylserine, phosphatidylethanolamine, phosphatidic acid, and sulfatide, critical for synaptic functions. Mice expressing APOE3-Jac have reduced amyloid pathology, plaque-associated immune responses, and neuritic dystrophy. The V236E substitution is also sufficient to reduce the aggregation of APOE4, whose gene allele is a major genetic risk factor for AD and DLB. These findings suggest that targeting APOE aggregation might be an effective strategy for treating a subgroup of individuals with AD and DLB.
1247P Management of infusion-related reactions (IRRs) in patients receiving amivantamab
Authors: K. Park, J.K. Sabari, E.B. Haura, C.A. Shu, A. Spira, R. Salgia, K.L. Reckamp, R.E. Sanborn, R. Govindan, J.M. Bauml, J.C. Curtin, J. Xie, A. Roshak, P. Lorenzini, D. Millington, M. Thayu, R.E. Knoblauch, B.C. Cho
Journal: Annals of Oncology (2021)
Abstract 12310: First Real-World Impact of a Novel Digital Medicine Program on Medication Adherence and Hospital Utilization Among Heart Failure Patients
Authors: Tabassum Salam, Dominique Medaglio, Lisa Deal, Melody Tran, Robert Plowman
Journal: Circulation (2018)

Introduction: Among heart failure (HF) patients, poor medication adherence is associated with increased healthcare utilization. Addressing nonadherence is integral to developing effective treatment...
59TiP Phase III study of NUC-1031 + cisplatin vs gemcitabine + cisplatin for first-line treatment of patients with advanced biliary tract cancer (NuTide:121)
Authors: J. Knox, M.G. McNamara, L. Goyal, D. Cosgrove, C. Springfeld, K. Sjoquist, J.O. Park, H. Verdaguer, C. Braconi, P. Ross, D-Y. Oh, A. De Gramont, R.T. Shroff, J.R. Zalcberg, D. Palmer, J.W. Valle
Journal: Annals of Oncology (2021)
Prevalence of Arthritis and Arthritis-Attributable Activity Limitation — United States, 2016–2018
Authors: Kristina A. Theis, Louise B. Murphy, Dana Guglielmo, Michael A. Boring, Catherine A. Okoro, Lindsey M. Duca, Charles G. Helmick
Journal: MMWR Morbidity and Mortality Weekly Report (2021)

Arthritis has been the most frequently reported main cause of disability among U.S. adults for >15 years (1), was responsible for >$300 billion in arthritis-attributable direct and indirect annual costs in the U.S. during 2013 (2), is linked to disproportionately high levels of anxiety and depression (3), and is projected to increase 49% in prevalence from 2010-2012 to 2040 (4). To update national prevalence estimates for arthritis and arthritis-attributable activity limitation (AAAL) among U.S. adults, CDC analyzed combined National Health Interview Survey (NHIS) data from 2016-2018. An estimated 58.5 million adults aged ≥18 years (23.7%) reported arthritis; 25.7 million (10.4% overall; 43.9% among those with arthritis) reported AAAL. Prevalence of both arthritis and AAAL was highest among adults with physical limitations, few economic opportunities, and poor overall health. Arthritis was reported by more than one half of respondents aged ≥65 years (50.4%), adults who were unable to work or disabled* (52.3%), or adults with fair/poor self-rated health (51.2%), joint symptoms in the past 30 days (52.2%), activities of daily living (ADL)† disability (54.8%), or instrumental activities of daily living (IADL)§ disability (55.9%). More widespread dissemination of existing, evidence-based, community-delivered interventions, along with clinical coordination and attention to social determinants of health (e.g., improved social, economic, and mental health opportunities), can help reduce widespread arthritis prevalence and its adverse effects.
Androgens and Development of Posttransplantation Diabetes Mellitus in Male Kidney Transplant Recipients: A Post Hoc Analysis of a Prospective Study
Authors: Suzanne P. Stam, Sara Sokooti, Michele F. Eisenga, Anna van der Veen, António W. Gomes-Neto, Peter R. van Dijk, Jelmer J. van Zanden, Michel J. Vos, Ido P. Kema, André P. van Beek, Stephan J.L. Bakker
Journal: Diabetes Care (2021)

OBJECTIVE Posttransplantation diabetes mellitus (PTDM) effects up to 30% of all kidney transplant recipients (KTR). Recent studies in mice found that sufficient androgen levels are necessary for β-cell health and adequate insulin secretion. This raises the question whether a similar relationship might be present in KTR. Hence, we hypothesized that dihydrotestosterone and testosterone are associated with the development of PTDM in male KTR. RESEARCH DESIGN AND METHODS We conducted a post hoc analyses of a prospective single-center cohort study including adult male KTR with a functioning graft ≥1 year posttransplantation. Androgen levels were assessed by liquid chromatography–tandem mass spectrometry. Development of PTDM was defined according to the American Diabetes Association’s criteria. RESULTS We included 243 male KTR (aged 51 ± 14 years), with a median dihydrotestosterone 0.9 (0.7–1.3) nmol/L and testosterone of 12.1 (9.4–15.8) nmol/L. During 5.3 (3.7–5.8) years of follow-up, 28 KTR (11.5%) developed PTDM. A clear association was observed, as 15 (19%), 10 (12%), and 3 (4%) male KTR developed PTDM in the respective tertiles of dihydrotestosterone (P = 0.008). In Cox regression analyses, both dihydrotestosterone and testosterone as continuous variables were inversely associated with the risk to development PTDM, independent of glucose and HbA1c (hazard ratio [HR] 0.31 [95% CI 0.16–0.59], P &amp;lt; 0.001; and HR 0.32 [95% CI 0.15–0.68], P = 0.003, respectively). CONCLUSIONS Our results suggest that low androgen levels are a novel potential modifiable risk factor for the development of PTDM in male KTR.
A planetary health curriculum for medicine
Authors: Anna Moore
Journal: BMJ (2021)

A planetary health curriculum for medicineNeeded yesterday; make it a reality today Anna Moore Health Education England population health fellow Undergraduate medical curriculums are notoriously packed and space for new content is hotly contested.But what if there was a way that medical schools could ensure that students graduate with enhanced clinical knowledge, skills and competence and a deep understanding of health, as well as disease, by adding just one new theme?
Sustainable Developmental Goals interrupted: Overcoming challenges to global child and adolescent health
Authors: Zulfiqar A. Bhutta, Kathryn M. Yount, Quique Bassat, Caitlin E. Moyer
Journal: PLoS Medicine (2021)

Few predicted, in September 2015, when the millennium development goals (MDGs) closed and the Sustainable Development Goals (SDGs) were signed into a global compact, that we might soon face the largest global public health challenge in over a century.Not only has COVID-19 killed nearly five million people to date [1], and upended global economies, but it has also seriously impacted child health and development across the world, especially in lowand lower middle-income countries (LLMICs) [2].For the first time in living memory, over 1.6 billion children are out of school [3] and efforts on reopening schools have sparked rancorous and divisive debates.There are legitimate concerns that COVID-19 has negatively impacted progress in achieving the SDGs globally, and that urgent redirective strategies are needed before hard-earned gains from the 2000-2015 MDG period are reversed [4].In October 2020, we announced a Special Issue of PLOS Medicine devoted to themes of child and adolescent health in the context of the SDGs [5].At the time of our call for papers, the world was consumed by efforts to counter the COVID-19 pandemic, and has remained so; however, we set out to solicit papers on topics and problems that were left unaddressed at the end of the MDG period in 2015, issues that preceded the current pandemic and that are likely to persist after the current crisis abates.Our objectives were to encourage submissions pertaining to specific areas related to child development, adolescent health, and the social determinants of health.The depth and breadth of submitted articles, now reflected in the accompanying research papers, remarkably demonstrates the global significance of these issues and the multi-faceted approaches used to address them.The Special Issue represents a kaleidoscope of papers that span a range of topics and areas including child health and its drivers, including newborn health, and immunizations and other strategies to combat treatable and preventable infections; nutrition support and innovative interventions to improve infant and child survival and growth; adolescent health and outcomes, in areas such as gender equity, HIV, injuries, peer/school-based violence, and mental health; and the socio-contextual determinants of health relevant for all stages of childhood and adolescent development, including, for example, those related to conflict, environmental conditions, and the family and parenting environment.This Special Issue has contextual relevance in light of the broad spectrum of direct and collateral effects wrought by the COVID-19 pandemic on social, economic, and health-related conditions [6].These effects, direct and indirect, can be grouped broadly in relation to current
Underrepresentation of skin of color in medical education: An updated analysis of popular question banks
Authors: Virginia A. Jones, Kayla Clark, Ivy Obonyo, Maria M. Tsoukas
Journal: Journal of the American Academy of Dermatology (2021)

To the Editor: We laud Meckley et al1 for expanding upon our findings from our study "Skin of color representation in medical education: An analysis of popular preparatory materials used for United States Medical Licensing Examinations" (USMLE).2 Their analysis of skin of color (SoC) images in AMBOSS Step 1, Kaplan Step 1, USMLERx Step 1 Qmax, and self-assessment examinations provided by the National Board of Medical Examiners (NBME) is undoubtedly an enormous addition to our original findings and to the contributions by Mitello et al.
245P Palbociclib combined with aromatase inhibitors (AIs) in women ≥75 years with oestrogen receptor positive (ER+ve), human epidermal growth factor receptor 2 negative (HER2-ve) advanced breast cancer: A real-world multicentre UK study
Authors: S. El Badri, B. Tahir, K. Balachandran, P. Bezecny, F. Britton, K. DeSouza, D. Hills, M. Moe, T. Pigott, A. Proctor, Y. Shah, R. Simcock, A. Stansfeld, A. Synowiec, M. Theodoulou, M. Verrill, A. Wadhawan, C. Harper-Wynne, C. Wilson
Journal: Annals of Oncology (2021)
1577P Early mortality linked to COVID-19 in cancer patients as compared to historical control in pre-pandemic times
Authors: R. Dienstmann, P. De Marchi, M. Costa e Silva, M. Menezes, H. Cruz, R. Paes, J. Alves da Silva, A.C. Messias, J.A.F. Canedo, A.C. De Melo, T. Reinert, A. Jacome, B.S. Ferreira, C. Mathias, C.H. Barrios, C. Gil Ferreira, B.L. Ferrari
Journal: Annals of Oncology (2021)
Availability of essential diagnostics in ten low-income and middle-income countries: results from national health facility surveys
Authors: Harika Yadav, Devanshi Shah, Shahin Sayed, Susan Horton, Lee F Schroeder
Journal: The Lancet Global Health (2021)

BackgroundPathology and laboratory medicine diagnostics and diagnostic imaging are crucial to achieving universal health coverage. We analysed Service Provision Assessments (SPAs) from ten low-income and middle-income countries to benchmark diagnostic availability.MethodsDiagnostic availabilities were determined for Bangladesh, Haiti, Malawi, Namibia, Nepal, Kenya, Rwanda, Senegal, Tanzania, and Uganda, with multiple timepoints for Haiti, Kenya, Senegal, and Tanzania. A smaller set of diagnostics were included in the analysis for primary care facilities compared with those expected at hospitals, with 16 evaluated in total. Surveys spanned 2004–18, including 8512 surveyed facilities. Country-specific facility types were mapped to basic primary care, advanced primary care, or hospital tiers. We calculated percentages of facilities offering each diagnostic, accounting for facility weights, stratifying by tier, and for some analyses, region. The tier-level estimate of diagnostic availability was defined as the median of all diagnostic-specific availabilities at each tier, and country-level estimates were the median of all diagnostic-specific availabilities of each of the tiers. Associations of country-level diagnostic availability with country income as well as (within-country) region-level availability with region-specific population densities were determined by multivariable linear regression, controlling for appropriate covariates including tier.FindingsMedian availability of diagnostics was 19·1% in basic primary care facilities, 49·2% in advanced primary care facilities, and 68·4% in hospitals. Availability varied considerably between diagnostics, ranging from 1·2% (ultrasound) to 76·7% (malaria) in primary care (basic and advanced) and from 6·1% (CT scan) to 91·6% (malaria) in hospitals. Availability also varied between countries, from 14·9% (Bangladesh) to 89·6% (Namibia). Availability correlated positively with log(income) at both primary care tiers but not the hospital tier, and positively with region-specific population density at the basic primary care tier only.InterpretationMajor gaps in diagnostic availability exist in many low-income and middle-income countries, particularly in primary care facilities. These results can serve as a benchmark to gauge progress towards implementing guidelines such as the WHO Essential Diagnostics List and Priority Medical Devices initiatives.FundingBill & Melinda Gates Foundation.
630P Time course profile of adverse events of interest and serious adverse events with darolutamide in the ARAMIS trial
Authors: C.J. Gratzke, K. Fizazi, N.D. Shore, M.R. Smith, S. Feyerabend, M. Grabbert, J. Carles, T. Lebret, E. Vjaters, P. Werbrouck, M. Miskic, J. Ortiz, A. Schmall, M.A. Le Berre, F. Verholen
Journal: Annals of Oncology (2021)
581P Patient (pt) reported pain in men with metastatic castration-resistant prostate cancer (mCRPC) receiving talazoparib (TALA): TALAPRO-1
Authors: F. Saad, J.S. de Bono, P. Barthelemy, T. Dorff, N. Mehra, G. Scagliotti, A. Stirling, J-P. Machiels, V. Renard, M. Maruzzo, C.S. Higano, H.P. Gurney, C. Healy, H. Bhattacharyya, B. Arondekar, A. Niyazov, K. Fizazi
Journal: Annals of Oncology (2021)
925TiP The efficacy of immunonutrition in improving tolerance to chemoradiotherapy in patients with head and neck cancer, receiving nutritional counseling: Study protocol of a randomized, open-label, parallel group, bicentric pilot study
Authors: R. Tancredi, E. Cereda, C. Klersy, M.T. Nardi, S. Masi, S. Crotti, V. Caissutti, C. Brovia, E. Bonzano, P. Comoli, L. Catenacci, I. Imarisio, P. Bossi, M.G. Ghi, P. Pedrazzoli, R. Caccialanza
Journal: Annals of Oncology (2021)
LBA9 IMpower010: Sites of relapse and subsequent therapy from a phase III study of atezolizumab vs best supportive care after adjuvant chemotherapy in stage IB-IIIA NSCLC
Authors: E. Felip, E. Vallieres, C. Zhou, H. Wakelee, I. Bondarenko, H. Sakai, H. Saito, G. Ursol, K. Kawaguchi, Y. Liu, E. Levchenko, N. Kislov, M. Reck, R. Liersch, V.A. McNally, Q. Zhu, B. Ding, E. Bennett, B. Gitlitz, N.K. Altorki
Journal: Annals of Oncology (2021)
742P Survival in patients (pts) with advanced ovarian cancer (AOC) changes with cumulative number of risk factors (RFs): A US real-world (RW) analysis
Authors: D. Chase, J. Perhanidis, D. Gupta, L. Kalilani, S. Lechpammer, T. Woodward, A. González-Martín
Journal: Annals of Oncology (2021)