tbuckley/cabot-search huggingface dataset:
European Consensus Conference on Diagnosis and Treatment of Germ Cell Cancer: A Report of the Second Meeting of the European Germ Cell Cancer Consensus Group (EGCCCG): Part II
Authors: Susanne Krege, Jörg Beyer, Rainer Souchon, Peter Albers, Walter Albrecht, Ferran Algaba, Michael Bamberg, István Bodrogi, Carsten Bokemeyer, Eva Cavallin-Ståhl, Johannes Classen, Christoph Clemm, Gabriella Cohn-Cedermark, Stéphane Culine, Gedske Daugaard, Pieter H.M. De Mulder, Maria De Santis, Maike de Wit, Ronald de Wit, Hans Günter Derigs, Klaus-Peter Dieckmann, Annette Dieing, Jean-Pierre Droz, Martin Fenner, Karim Fizazi, Aude Flechon, Sophie D. Fosså, Xavier Garcia del Muro, Thomas Gauler, Lajos Geczi, Arthur Gerl, Jose Ramon Germa-Lluch, Silke Gillessen, Jörg T. Hartmann, Michael Hartmann, Axel Heidenreich, Wolfgang Hoeltl, Alan Horwich, Robert Huddart, Michael Jewett, Johnathan Joffe, William G. Jones, László Kisbenedek, Olbjørn Klepp, Sabine Kliesch, Kai Uwe Koehrmann, Christian Kollmannsberger, Markus Kuczyk, Pilar Laguna, Oscar Leiva Galvis, Volker Loy, Malcolm D. Mason, Graham M. Mead, Rolf Mueller, Craig Nichols, Nicola Nicolai, Tim Oliver, Dalibor Ondrus, Gosse O.N. Oosterhof, Luis Paz-Ares, Giorgio Pizzocaro, Jörg Pont, Tobias Pottek, Tom Powles, Oliver Rick, Giovanni Rosti, Roberto Salvioni, Jutta Scheiderbauer, Hans-Ulrich Schmelz, Heinz Schmidberger, Hans-Joachim Schmoll, Mark Schrader, Felix Sedlmayer, Niels E. Skakkebaek, Aslam Sohaib, Sergei Tjulandin, Padraig Warde, Stefan Weinknecht, Lothar Weissbach, Christian Wittekind, Eva Winter, Lori Wood, Hans von der Maase
Journal: European Urology (2008)
Real-time three-dimensional echocardiographic follow-up of patients with ischemic cardiomyopathy undergoing infarct exclusion surgery Jian Xin Qin, Takahiro Shiota, Patrick M. McCarthy, Neil L. Greenberg, Fabrice Bauer, Marta Sitges, Jeanne K. Drinko, Xi-Yi Hang, Yong Jin Kim, Kathy J. Hoercher, Tiffany Buda, Nicholas G. Smedira, James D. Thomas. The Cleveland Clinic Foundation, Cleveland, OH
Journal: Journal of the American College of Cardiology (2001)
TCT-729 Discontinuation of Long-Term Clopidogrel Therapy is Associated with Death and Myocardial Infarction after Saphenous Vein Graft Percutaneous Coronary Intervention
Authors: Amit Sachdeva, Sumati Bavisetty, Gerald Beckham, Albert Shen, Vicken Aharonian, Prakash Mansukhani, Gregg Stone, Martin Leon, Jeffrey Moses, Naing Moore, Ric Hyett, Richard Contreras, Somjot Brar
Journal: Journal of the American College of Cardiology (2012)
Expansion of New York Academy of Medicine.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 17334: Illicit Drug Users Infective Endocarditis: Winter Effect Causing Lowest Incidence but the Highest Mortality
Authors: Kartik Dhaduk, Hardik Sonani, Malav Patel, Rushik Bhuva, George Jolly, Ashish Kumar, Rupak Desai, Jagdish Desai
Journal: Circulation (2018)

Introduction: Many cardiovascular diseases are known to have seasonal variation and that helps to better understand the disease. From the national sample, we studied the incidence and mortality pattern in infective endocarditis (IE) in illicit drug users (IDU) to delineate the seasonal effect on the disease. Methods: National inpatient sample (NIS) database from the year 2008 to 2014 was used to identify cases of IE and IDU (opiates, cocaine and amphetamine) in between age 15-65 years. After excluding cases with congenital cardiac anomalies, rheumatic, lupus and transfer status (possible doubling in count), data was analyzed using t-test, x 2 test and multivariate logistic regression analysis methods with SAS 9.4 software. Results: Out of total 144,593 identified cases of IE, 22,806 cases (15.77%) were illicit drug users infective endocarditis (IDU-IE). Patients in IDU-IE group were younger compare to non-IDU IE group (median± SE, p-value; 35± 0.39 vs 52± 0.11 yr, &lt;0.001) but had higher longer hospital stay (12± 0.27 vs 10±0.1 days, &lt;0.001). On seasonal pattern, highest hospitalisation was found in autumn (25.69%) followed by summer (25.23%), spring (22.8) and winter (19.5%) (figure1). In subgroup analysis, the most vulnerable population was in age group 15-35 years (49.8%), white race (71.8%) with Medicaid insurance (46.6%) in southern USA (37.6%). After adjusting for potential confounders in regression, mortality in winter was highest (aOR (95% CI), p-value; 1.40 (1.00-1.94), 0.04) (figure1). Old age &gt;50 (2.43, (1.76-3.38), &lt;0.001), &gt;1 comorbidities (2.09 (1.59- 2.74), &lt;0.001) and male (1.5 (1.18-1.91), &lt;0.001) were predictors of higher mortality. Conclusion: In conclusion, drug use pattern is consistent with drug users IE pattern. But highest mortality despite of lowest incidence rate in winter suggests involvement of environmental and physical factors. Identifying these factors will help improving patient care and health care burden.
Human Neuropsychology
Authors: Robert J. Richards
Journal: JAMA (1978)

<i>Human Neurophysiology</i>, by the distinguished neurophysiologists Henri Hécaen and Martin Albert, displays the synthesizing and provocative power of the sophisticated textbook. The work, a revision and thorough updating of Hécaen's<i>Introduction á la Neuropsychologie</i>(1972), seeks to analyze human cognitive activity using evidence derived mostly from experimental and clinical research on cerebral disorders (eg, aphasias, apraxias, sensory illusions, and agnosias of various kinds) and from this to develop a model of brain function and dynamics. Hécaen's own research, beginning at the time of World War II, has been largely responsible for demonstrating the conceptual and methodological cul-de-sac of arguing either for narrowly delimited centers of specific psychological function (a heritage of phrenology) or for the mass action of nonspecialized brain regions (the response of Lashley and the Gestaltists). The authors depict the functional organization of the brain as "a dynamic combination of complex systems, of brain areas with specific and
Detection of coronary restenosis after successfull coronary angioplasty by contrast enhanced transthoracic doppler monitoring of coronary flow reserve Massimo Ruscazio, Roberta Montisci, Gabriele Marongiu, Carlo Caiati, Raimondo Pirisi, Mauro Cadeddu, Giorgio Lai, Paolo Colonna, Lijun Chen, Luigi Meloni, Sabino Iliceto. Department of Cardiovascular and Neurological Science, University of Cagliari, Cagliari, Italy
Journal: Journal of the American College of Cardiology (2001)
Cluster of HIV-Infected Adolescents and Young Adults—Mississippi, 1999
Journal: JAMA (2000)

From February through June 1999, seven human immunodeficiency virus (HIV)-infected young persons were identified in a small town in rural Mississippi. Two persons were identified through routine voluntary HIV testing during sexually transmitted disease (STD) evaluations, and five were identified subsequently through contact investigation by the local health department. Contact investigation identified sex partners and social contacts (i.e., persons who shared social surroundings) and defined a social network of 122 sex and social contacts. Seven (9%) of 78 persons tested from the social network were HIV-infected. Within the social network, a sexual contact network of 44 persons (the seven HIV-infected persons and their sex partners) was identified. The Mississippi State Department of Health asked CDC to join the investigation to describe further the cluster and help direct prevention efforts. This report summarizes the investigation of this cluster and underscores the need for HIV prevention and treatment in rural areas.
Constipation kills
Authors: Heather L. Van Epps
Journal: The Journal of Experimental Medicine (2005)

Constipation killsCellular constipation can be deadly, according to a study on page 1587.Wang and colleagues show that cells get clogged with aborted secretory cargo when they lack an enzyme that helps form vesicles.Deletion of this enzyme proved lethal in mice, halting brain, bone and vascular development.The enzyme in question is a protein tyrosine phosphatase (PTP) called MEG2.MEG2 binds lipids and resides on intracellular vesicle membranes, where it clips phosphate residues from the fusion protein NSF.Once dephosphorylated, NSF initiates homotypic fusion between immature secretory vesicles, a critical step in protein secretion.Knocking out MEG2, the team found, prevented T cells (isolated from chimeric mice) from secreting the autocrine growth factor interleukin-2, stunting T cell proliferation in response to stimulation.Electron micrographs of the deficient T cells revealed that the cells lacked mature secretory vesicles and were clogged with the dense remains of fusion-incompetent vesicles.Platelets that lacked MEG2 were also dysfunctional, failing to aggregate when exposed to the clotting factor thrombin.But the MEG2 defect spared neutrophils and macrophages, although these cells rely on the same cellular machinery for vesicle release.Cell type-specific PTPs might compensate for MEG2's absence in neutrophils and macrophages.Besides looking for these PTPs, the group is also investigating the mechanism behind the developmental defects in the MEG2-deficient mice, which they suspect result from an inability to produce growth factors that direct the migration and differentiation of progenitor cells.
Competition, regulation, and hospital cost
Authors: D. N. Mendelson
Journal: JAMA (1989)

<h3>In Reply. —</h3> Mr Mendelson's comparison of our figures with those from 1978 through 1982 is misleading, since we focus on rates of hospital cost inflation after adjusting for changes in wage rates, involvement in medical education, and other factors, while he focuses on unadjusted cost-inflation figures. We have no adjusted inflation figures for 1978 through 1982, but, as part of recent work, we have calculated adjusted rates of inflation for the entire decade from 1972 through 1982, which can be compared with adjusted inflation figures for 1982 through 1986. While Mr Mendelson's unadjusted figures show large differences between Massachusetts and the rest of the nation for 1978 through 1982, our figures show Massachusetts hospitals to have an adjusted rate of inflation from 1972 through 1982 only 1.8% lower than that of the rest of the nation (excluding Maryland, New York, New Jersey, and California), a statistically insignificant figure (<i>P</i>
Adenoviral-mediated gene transfer of the cardiac transcription factor Nkx2.5 into adult cardiomyocytes Angela M. Brown, Mary S. Rackley, Robert S. Ross, Terrence X. O'Brien. Medical University of South Carolina, Gazes Institute, RHJ-VAMC, Charleston, SC, UCLA School of Medicine, Los Angeles, CA
Journal: Journal of the American College of Cardiology (2001)
THE BOOK REVIEW BUSINESS.
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leads from the MMWR. Recommendations for protection against viral hepatitis
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sirolimus plus prednisolone vs sirolimus monotherapy for kaposiform hemangioendothelioma: a randomized clinical trial
Authors: Yi Ji, Siyuan Chen, Jiangyuan Zhou, Kaiying Yang, Xuepeng Zhang, Bo Xiang, Tong Qiu, Xue Gong, Zixin Zhang, Yuru Lan, Fan Hu, Feiteng Kong, Qingxia Qiu, Yongbo Zhang
Journal: Blood (2022)
Regorafenib plus nivolumab as first-line therapy for unresectable hepatocellular carcinoma (uHCC): Multicenter phase 2 trial (RENOBATE).
Authors: Changhoon Yoo, Baek-Yeol Ryoo, Hyung-Don Kim, Min-Hee Ryu, Beodeul Kang, Hong Jae Chon, Jung Yong Hong, Ho Yeong Lim
Journal: Journal of Clinical Oncology (2022)

415 Background: The immunomodulatory effect of regorafenib may enhance the anti-tumor activity of nivolumab in patients with uHCC. We report results from a phase 2 study of regorafenib plus nivolumab as first-line therapy in patients with uHCC. Methods: In this open-label, multi-center, single-arm study, patients with &gt;19 years, ECOG PS 0 or 1, BCLC stage B or C, and no prior systemic therapy were eligible. Patients received intravenous nivolumab 480 mg, every 4 weeks, and oral regorafenib 80 mg daily, 3 weeks on/1 week off, every 4 weeks. Tumor response was evaluated per RECIST v1.1, every 8 weeks (fixed schedule). Primary endpoint was overall response rates (ORR) per RECIST v1.1. Secondary endpoints were progression-free survival (PFS), overall survival (OS), ORR per mRECIST, and safety profile per NCI-CTCAE v5. Results: A total of 42 patients were enrolled between JUL-2020 and JAN-2021. Median age was 61 years (range, 40-79), and 31 patients (73.8%) were male. Most patients had BCLC C stage (n=38, 90.5%) and hepatitis B virus infection (n=30, 71.4%). Extrahepatic metastasis was noted in 36 patients (85.7%) and baseline serum AFP levels were &gt;400 ng/mL in 17 patients (40.5%). With median follow-up duration of 9.2 months (95% CI, 8.5-9.9 months), 21 patients were ongoing in this study. ORR per RECIST v1.1 was 31.0% (CR 1 [2.4%] and PR 12 [28.6%]), and ORR per mRECIST was 35.7% (CR 4 [9.5%] and PR 11 [26.2%]). Median PFS was 5.5 months (95% CI, 1.8-9.1 months) and median OS was not reached. The 6-months PFS and OS were 49.9% and 90.4%. Most common adverse events were hand-foot skin reaction (n=14, 33.3%), skin rash (12, 28.5%), and alopecia (10, 23.8%). Conclusions: Regorafenib plus nivolumab shows promising efficacy outcomes in uHCC. There was no unexpected safety signals and most of toxicities were manageable. Clinical trial information: NCT04310709.
Is tezepelumab more than just an anti-eosinophil drug?
Authors: Adil Adatia, Mustafaa Wahab, Imran Satia
Journal: European Respiratory Journal (2021)

Tezepelumab significantly reduces airway eosinophilia, which is the most likely mechanism by which it reduces the risk of asthma exacerbation in patients with moderate–severe asthma, but has little effect on airway hyperresponsiveness to mannitol <https://bit.ly/3xnt5sS>
Skeletal muscle wasting during neoadjuvant therapy as a prognosticator in patients with esophageal and esophagogastric junction cancer: A systematic review and meta-analysis
Authors: Peiyu Wang, Shaodong Wang, Xiao Li, Guihu Lin, Yi Ma, Rongxin Xiao, Haoran Li, Mantang Qiu, Fan Yang
Journal: International Journal of Surgery (2022)
The Surgery of Pulmonary Tuberculosis.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Investigation of sex and gender differences in oncology gains momentum: ESMO announces the launch of a Gender Medicine Task Force
Authors: B.C. Özdemir, S. Oertelt-Prigione, A.A. Adjei, S. Borchmann, J.B. Haanen, A. Letsch, O. Mir, A. Quaas, R.H.A. Verhoeven, A.D. Wagner
Journal: Annals of Oncology (2022)
Are NKT cells a useful predictor of COVID-19 severity?
Authors: Hui-Fern Koay, Nicholas A. Gherardin, Thi H.O. Nguyen, Wuji Zhang, Jennifer R. Habel, Rebecca Seneviratna, Fiona James, Natasha E. Holmes, Olivia C. Smibert, Claire L. Gordon, Jason A. Trubiano, Katherine Kedzierska, Dale I. Godfrey
Journal: Immunity (2022)
Gastroesophageal Reflux
Journal: Thorax (1989)

Spontaneous pneumothorax due to metastatic carcinoma ofthe rectum The paper by Mr PE Beam and Mr OJ Lau (June 1988;43: 496) mentions that pneumothorax can be produced by metastasis from osteogenic sarcoma, Ewing's tumour, Wilm's tumour, melanoma, and endometrial adenocarcinoma, and that metastatic carcinoma of the rectum has previously not been reported as a cause of pneumothorax.We wish to add that various other primary malignancies, including fibrosarcoma, angiosarcoma, synovial cell sar- coma, leiomyosarcoma, etc, have also been reported to result in pneumothorax.'Although breakdown of the tumour directly into the pleural space, as mentioned by the authors, can result in pneumothorax, alternative mechanisms of pneumothorax formation have also been reported.These include tumour embolus and subsequent infarction and necrosis of the lung with air leak,2 and rupture of lung tissue due to secondary deposits beneath the pleura, producing free interstitial air that may trek along the vascular sheaths to the mediastinum and rupture through the mediastinal pleura.3The occasional association of pneumomediastinum and the spontaneous resolution of pneumothorax in some patients strongly support the latter hypothesis of pneumothorax formation in metastatic lung disease.'2
Telemedicine for cardiac surgery candidates: The initial Swiss experience Augusto F. Gallino, Andrea Menafoglio, Sr., Luca Calanca, Agostino Faggiotto, Luigi Caoduro, Ludwig von Segesser. Division of Cardiology, Ospedale San Giovanni, Bellinzona, Switzerland, Division of Cardiac Surgery, University Hospital, Lausanne, Switzerland
Journal: Journal of the American College of Cardiology (2001)
Sea-Sickness
Authors: R. V. Ash
Journal: BMJ (1883)

to see a short communication in the JOURNAL of July 7th on sea-sickness, and hope all who have the chance will contribute something to our at present small stock of knowledge on this distressing complaint.To me it is particularly interesting, for it is my lot to be painfully sensitive to the movements of a ship, and to have passed more than a year of my service on the sea.I have an idea that the sympathetic nervous system is the culprit, for the following reasons.1. Flushing of the face is a common sign of the approach of nausea, and we all know that irritation of that nerve will cause this, as well as an extra secretion in a gland.2. There is an increase in the quantity of fluid ejected from the stomach after it has lain there for a short time.In my own case I frequently noticed, and I subsequently verified it in many others,
Alterations in circulating plasma adenosine in dilated cardiomyopathy: A baseline and dipyridamole stress study Christina Petersen, Francesca Guideri, Alessandro Pingitore, Lorenza Pratali, Emilio Pasanisi, Eugenio Picano, Franco Laghi Pasini. CNR, Institute of Clinical Physiology, Pisa, Italy, Department of Internal Medicine, Section of Clinical Immunology, Siena, Italy
Journal: Journal of the American College of Cardiology (2001)
Current Medical Literature.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal