tbuckley/cabot-search huggingface dataset:
Tracking immature reticulocyte proteins for improved detection of recombinant human erythropoietin (rhEPO) abuse
Authors: Holly D. Cox, Geoffrey D. Miller, Abhilasha Manandhar, Jacob D. Husk, Andre K. Crouch, Daniel Eichner
Journal: American Journal of Hematology (2021)

Athletes abuse recombinant human erythropoietin (rhEPO) and erythropoiesis stimulating agents to increase hemoglobin mass and improve performance. To evade detection, athletes have developed sophisticated blood doping regimens, which often include rhEPO micro-dosing. Detection of these methods requires biomarkers with increased sensitivity and a sample matrix that is more amenable to frequent testing in the field. We have developed a method to measure two immature reticulocyte proteins, CD71 and ferrochelatase (FECH), and one total erythrocyte protein, Band 3, in dried blood spots (DBS). This method was tested in response to rhEPO administration after low doses, 40 IU/kg, micro-doses, 900 IU, or saline injection in 20 healthy subjects. During administration of low-dose rhEPO, the mean CD71/Band 3 and FECH/Band 3 ratio increased by 412 ± 197% and 250 ± 44%, respectively. The mean response for the current biomarker, RET%, increased by 195 ± 35%. During administration of rhEPO micro-doses, CD71/Band 3 increased to 127 ± 25% on day 35 and 139 ± 36% on day 39, while no increase was observed in RET%. After rhEPO administration, during the washout phase, mean values decreased to a minimum of 64 ± 4% and 64 ± 11% for CD71/Band 3 and RET%, respectively. However, CD71/Band 3 remained below 75% of baseline for at least 4 weeks after rhEPO injection, while RET% returned to baseline levels. The results demonstrate that immature reticulocyte proteins have a larger response to rhEPO administration than the current biomarker, RET%, and can be monitored in the DBS matrix.
Long-Term Exposure to Transportation Noise and Risk of Incident Stroke: A Pooled Study of Nine Scandinavian Cohorts
Authors: Nina Roswall, Andrei Pyko, Mikael Ögren, Anna Oudin, Annika Rosengren, Anton Lager, Aslak H. Poulsen, Charlotta Eriksson, David Segersson, Debora Rizzuto, Eva M. Andersson, Gunn Marit Aasvang, Gunnar Engström, Jeanette T. Jørgensen, Jenny Selander, Jesper H. Christensen, Jesse Thacher, Karin Leander, Kim Overvad, Kristina Eneroth, Kristoffer Mattisson, Lars Barregård, Leo Stockfelt, Maria Albin, Matthias Ketzel, Mette K. Simonsen, Mårten Spanne, Ole Raaschou-Nielsen, Patrik K.E. Magnusson, Pekka Tiittanen, Peter Molnar, Petter Ljungman, Timo Lanki, Youn-Hee Lim, Zorana J. Andersen, Göran Pershagen, Mette Sørensen
Journal: Environmental Health Perspectives (2021)

Background: Transportation noise is increasingly acknowledged as a cardiovascular risk factor, but the evidence base for an association with stroke is sparse. Objective: We aimed to investigate the association between transportation noise and stroke incidence in a large Scandinavian population. Methods: We harmonized and pooled data from nine Scandinavian cohorts (seven Swedish, two Danish), totaling 135,951 participants. We identified residential address history and estimated road, railway, and aircraft noise for all addresses. Information on stroke incidence was acquired through linkage to national patient and mortality registries. We analyzed data using Cox proportional hazards models, including socioeconomic and lifestyle confounders, and air pollution. Results: During follow-up (median=19.5y), 11,056 stroke cases were identified. Road traffic noise (Lden) was associated with risk of stroke, with a hazard ratio (HR) of 1.06 [95% confidence interval (CI): 1.03, 1.08] per 10-dB higher 5-y mean time-weighted exposure in analyses adjusted for individual- and area-level socioeconomic covariates. The association was approximately linear and persisted after adjustment for air pollution [particulate matter (PM) with an aerodynamic diameter of ≤2.5μm (PM2.5) and NO2]. Stroke was associated with moderate levels of 5-y aircraft noise exposure (40–50 vs. ≤40 dB) (HR=1.12; 95% CI: 0.99, 1.27), but not with higher exposure (≥50 dB, HR=0.94; 95% CI: 0.79, 1.11). Railway noise was not associated with stroke. Discussion: In this pooled study, road traffic noise was associated with a higher risk of stroke. This finding supports road traffic noise as an important cardiovascular risk factor that should be included when estimating the burden of disease due to traffic noise. https://doi.org/10.1289/EHP8949
1387P Randomized phase II study comparing docetaxel vs paclitaxel in patients with esophageal squamous cell carcinoma who are refractory to fluoropyrimidine and platinum-based chemotherapy: OGSG1201
Authors: H. Hara, S. Yamamoto, T. Kii, R. Kawabata, J. Kawada, A. Takeno, J. Matsuyama, S. Ueda, H. Kawakami, Y. Okita, S. Endo, Y. Kimura, K. Yanagihara, T. Okuno, Y. Kurokawa, T. Shimokawa, T. Satoh
Journal: Annals of Oncology (2021)
Addressing context dependence in ecology
Authors: Jane A. Catford, John R.U. Wilson, Petr Pyšek, Philip E. Hulme, Richard P. Duncan
Journal: Trends in Ecology & Evolution (2021)

Context dependence is widely invoked to explain disparate results in ecology. It arises when the magnitude or sign of a relationship varies due to the conditions under which it is observed. Such variation, especially when unexplained, can lead to spurious or seemingly contradictory conclusions, which can limit understanding and our ability to transfer findings across studies, space, and time. Using examples from biological invasions, we identify two types of context dependence resulting from four sources: mechanistic context dependence arises from interaction effects; and apparent context dependence can arise from the presence of confounding factors, problems of statistical inference, and methodological differences among studies. Addressing context dependence is a critical challenge in ecology, essential for increased understanding and prediction.
383O MAYA trial: Temozolomide (TMZ) priming followed by combination with low-dose ipilimumab and nivolumab in patients with microsatellite stable (MSS), MGMT silenced metastatic colorectal cancer (mCRC)
Authors: F. Pietrantonio, F. Morano, S. Lonardi, A. Raimondi, L. Salvatore, F. Marmorino, S. Murgioni, N. Pella, L. Antonuzzo, G. Ritorto, A. Zaniboni, M. Ratti, F. Palermo, F. Pagani, M. Prisciandaro, C. Cagnazzo, I. Capone, M. Milione, M. Di Bartolomeo, F. de Braud
Journal: Annals of Oncology (2021)
62P Markers in assessment of osteoporosis therapy efficiency in hormone-dependent breast cancer
Authors: N.K. Guskova, O. Shlyk, O. Selyutina, I.V. Tselishcheva, A.S. Nozdricheva, L.N. Vashchenko, Y.S. Shatova, O.I. Kit, L.Y. Vladimirova
Journal: Annals of Oncology (2021)
1597P Vaccination against SARS-CoV-2 infection in patients with solid tumors: Experience from Institute for Oncology and Radiology of Serbia (IORS)
Authors: O.I. Djurmez, M. Calamac, M. Dimitrijevic, K. Serovic, I. Minic, J. Oblakovic-Babic, Z. Tomasevic, I. Bozovic-Spasojevic
Journal: Annals of Oncology (2021)
1124O Prediction of distant relapse in patients with invasive breast cancer from deep learning models applied to digital pathology slides
Authors: I.J. Garberis, C. Saillard, D. Drubay, B. Schmauch, V. Aubert, A. Jaeger, M. Sapateiro, A. de Lavergne, A. Kamoun, P. Courtiol, F. André, M. Lacroix-Triki
Journal: Annals of Oncology (2021)
629P Patient-reported outcomes in prostate cancer patients receiving PSMA-targeted radionuclide therapy
Authors: B.D. Gonzalez, M.I. Sun, C. Thomas, S. Eisel, L. Oswald, H.S.L. Jim, B. Ho, A. Patel, A. Tan, M.J. Niaz, C.N. Sternberg, A.M. Molina, D.M. Nanus, J. Osborne, N. Bander, S.T. Tagawa
Journal: Annals of Oncology (2021)
1092TiP Investigational (Inv) agents with or without pembrolizumab (pembro) or pembro alone in melanoma (mel): KEYMAKER-U02
Authors: R. Dummer, G.V. Long, A.C. Pavlick, M.A. Postow, A. Ribas, C. Robert, R.A. Scolyer, J.M. Taube, M. Tetzlaff, S-C. Su, R. Singh, S.J. Diede, H.A-H. Tawbi
Journal: Annals of Oncology (2021)
Abstract P299: Lifespan Body Mass Index Change by Race and Education: Gain and Loss During the Obesity Epidemic
Authors: Emmanuel M Quaye, Elizabeth Selvin, Chiadi Ndumele, Kunihiro Matsushita, Karen Bandeen-Roche, June Stevens, Priya Palta, Lynne Wagenknecht, Josef Coresh
Journal: Circulation (2016)

Introduction: The obesity epidemic in the United States accelerated in the late 1970’s and has lifelong effects. Longitudinal patterns of racial/ethnic and socioeconomic differences in weight gain across the lifespan are relatively uncharacterized. Hypothesis: Weight gain starts earlier and is larger in individuals who are black or have less education compared to those who are white or have higher education; weight loss after midlife shows similar patterns. Methods: We analyzed body mass index (BMI, kg/m2) changes in 14,291 ARIC participants (ages 45 - 64) followed from Visit 1 (1987 - 89) to Visit 5 (2011 - 13, Table 1). Participant BMI at age 25 was ascertained by self-report at the time of study enrollment. BMI change between these time points was categorized as stable (&lt;+/-2 kg/m2, average of &lt;+/-13 lbs.), increasing or decreasing (&gt;+/-2 kg/m2) and analyzed using multinomial logistic regression. Results: Table 1 shows BMI change and its associations with race and education. BMI change from age 25 to visit 1 (median age: 54) increased in 71%, was stable in 25% and decreased in 4% of participants. In midlife (visit 1 [1987 - 89] to visit 4 [1996 - 98]), an increase in BMI was more common (33%) compared to a decrease in BMI (7%). However, at older age (visit 4 [1996 - 98] to visit 5 [2011 - 2013]), both an increase and decrease in BMI (23% and 21% respectively) were common. Multinomial logistic regression demonstrated that being black, and having lower education, was consistently associated with weight gain from age 25 to midlife (visit 1). Interestingly, weight loss was also more common among blacks than whites, particularly at older age. Conclusion: Increases in BMI over the lifespan are common; weight gain from young adulthood to midlife, and both further weight gain and weight loss are common at older ages. Compared to whites, blacks experience more weight gain to midlife and greater late life weight loss. The implications for cardiovascular risk for weight gain and weight loss (a subset of which may mark poor health) needs to be explored.
940P Dose-escalation trial of OBP-301, novel telomerase-specific oncolytic virus in advanced hepatocellular carcinoma
Authors: J. Heo, J-D. Liang, C.W. Kim, H.Y. Woo, I-L. Shih, T-H. Su, Z-Z. Lin, S. Chang, Y. Urata, P-J. Chen
Journal: Annals of Oncology (2021)
668P Matching-adjusted indirect comparison (MAIC) of health-related quality of life (HRQoL) of nivolumab plus cabozantinib (N+C) vs pembrolizumab plus axitinib (P+A) in previously untreated advanced renal cell carcinoma (aRCC)
Authors: C.G. Porta, R. Motzer, F. Ejzykowicz, S.I. Blum, M. Hamilton, J.R. May, S. Huo, P. Kral, C. Ivanescu, T.K. Choueiri, D. Cella
Journal: Annals of Oncology (2021)
SARS-CoV-2 infection generates tissue-localized immunological memory in humans
Authors: Maya M.L. Poon, Ksenia Rybkina, Yu Kato, Masaru Kubota, Rei Matsumoto, Nathaniel I. Bloom, Zeli Zhang, Kathryn M. Hastie, Alba Grifoni, Daniela Weiskopf, Steven B. Wells, Basak B. Ural, Nora Lam, Peter A. Szabo, Pranay Dogra, Yoon S. Lee, Joshua I. Gray, Marissa C. Bradley, Maigan A. Brusko, Todd M. Brusko, Erica O. Saphire, Thomas J. Connors, Alessandro Sette, Shane Crotty, Donna L. Farber
Journal: Science Immunology (2021)

Adaptive immune responses to SARS-CoV-2 infection have been extensively characterized in blood; however, most functions of protective immunity must be accomplished in tissues. Here, we report from examination of SARS-CoV-2 seropositive organ donors (ages 10 to 74) that CD4+ T, CD8+ T, and B cell memory generated in response to infection is present in the bone marrow, spleen, lung, and multiple lymph nodes (LNs) for up to 6 months after infection. Lungs and lung-associated LNs were the most prevalent sites for SARS-CoV-2–specific memory T and B cells with significant correlations between circulating and tissue-resident memory T and B cells in all sites. We further identified SARS-CoV-2–specific germinal centers in the lung-associated LNs up to 6 months after infection. SARS-CoV-2–specific follicular helper T cells were also abundant in lung-associated LNs and lungs. Together, the results indicate local tissue coordination of cellular and humoral immune memory against SARS-CoV-2 for site-specific protection against future infectious challenges.
Abstract 15756: Clinical Impact of Early Enteral Nutrition for Patients With Acute Heart Failure Required Invasive Mechanical Ventilation
Authors: Koji Yasumoto, Masami Nishino, Hiroki Sugae, Shodai Kawanami, Kohei Ukita, Akito Kawamura, Motoki Yasunaga, Kyosuke Yanagawa, Hitoshi Nakamura, Yutaka Matsuhiro, Keisuke Yasumura, Akihiro Tanaka, Daisuke Nakamura, Yasuharu Matsunaga, Masamichi Yano, Masaki Yamato, Yasuyuki Egami, Ryu Shutta, Jun Tanouchi
Journal: Circulation (2018)

Introduction: Current guidelines for nutritional support in critically ill patients recommend early initiation (within 48 hour after intensive-care units (ICU) admission) of enteral nutrition. Howe...
1681P Biomarkers and physical condition in breast cancer survivors (BCS)
Authors: A. Ruiz-Casado, M. Romero-Elias, A. Alvarez-Bustos, C. Gonzalez, M. Mendez, M. Mendez, M. Blanco, A.M. Morito Aguilar, B. Puente, S. Martin, C. Maximiano, H. Cebolla, B. Cantos
Journal: Annals of Oncology (2021)
209P Interim results of a phase I/Ib study of SBT6050 monotherapy and pembrolizumab combination in patients with advanced HER2-expressing or amplified solid tumors
Authors: S.J. Klempner, M. Beeram, D. Sabanathan, A. Chan, E. Hamilton, S. Loi, D-Y. Oh, L.A. Emens, A. Patnaik, J.E. Kim, Y.H. Park, V. Odegard, S. Hamke, G. Jang, C. Jacquemont, N. Hunder, S.A. Piha-Paul
Journal: Annals of Oncology (2021)
Statins for Graves' orbitopathy (STAGO): a phase 2, open-label, adaptive, single centre, randomised clinical trial
Authors: Giulia Lanzolla, Elena Sabini, Marenza Leo, Francesca Menconi, Roberto Rocchi, Angela Sframeli, Paolo Piaggi, Marco Nardi, Claudio Marcocci, Michele Marinò
Journal: The Lancet Diabetes & Endocrinology (2021)
ULK1 inhibition promotes oxidative stress–induced differentiation and sensitizes leukemic stem cells to targeted therapy
Authors: Angela Ianniciello, Martha M. Zarou, Kevin M. Rattigan, Mary Scott, Amy Dawson, Karen Dunn, Zuzana Brabcova, Eric R. Kalkman, Colin Nixon, Alison M. Michie, Mhairi Copland, David Vetrie, Martin Ambler, Barbara Saxty, G. Vignir Helgason
Journal: Science Translational Medicine (2021)

ULK1 inhibition increases the sensitivity of leukemia stem cells to TKI therapy by modulating energy and redox balance.
1411P A prospective, multicenter, real-world study of apatinib in the treatment of gastric cancer
Authors: J. Xiong, J. Yang, W. Li, H. Xiong, G. Liu, F. Wu, N. Fan, X. Zeng, F. Huang, L. Yang, X. Tu, C. Shi, B. Yi, J. Ye, P. Li, C. Tang, J. Huang, P. Hou, W. Zang, S. Tan
Journal: Annals of Oncology (2021)
Troponin-Guided Coronary Computed Tomographic Angiography After Exclusion of Myocardial Infarction
Authors: Kuan Ken Lee, Anda Bularga, Rachel O’Brien, Amy V. Ferry, Dimitrios Doudesis, Takeshi Fujisawa, Shauna Kelly, Stacey Stewart, Ryan Wereski, Denise Cranley, Edwin J.R. van Beek, David J. Lowe, David E. Newby, Michelle C. Williams, Alasdair J. Gray, Nicholas L. Mills
Journal: Journal of the American College of Cardiology (2021)

Patients with suspected acute coronary syndrome in whom myocardial infarction has been excluded are at risk of future adverse cardiac events.
1330P Second-line nintedanib + docetaxel for patients with lung adenocarcinoma after first-line chemo-immunotherapy treatment: Updated efficacy and safety results from VARGADO Cohort C
Authors: C. Grohé, T. Wehler, T. Dechow, S. Henschke, W. Schütte, I. Dittrich, S. Hammerschmidt, H. Müller-Huesmann, C. Schumann, S. Krüger, J. Atz, R. Kaiser
Journal: Annals of Oncology (2021)
Biomimetic cartilage-lubricating polymers regenerate cartilage in rats with early osteoarthritis
Authors: Renjian Xie, Hang Yao, Angelina S. Mao, Ye Zhu, Dawei Qi, Yongguang Jia, Meng Gao, Yunhua Chen, Lin Wang, Dong-An Wang, Kun Wang, Sa Liu, Li Ren, Chuanbin Mao
Journal: Nature Biomedical Engineering (2021)
Biventricular Myocardial Fibrosis and Sudden Death in Patients With Brugada Syndrome
Authors: Chris Miles, Angeliki Asimaki, Irina Chis Ster, Michael Papadakis, Belinda Gray, Joseph Westaby, Gherardo Finocchiaro, Carlos Bueno-Beti, Bode Ensam, Joyee Basu, Gemma Parry-Williams, Hamish MacLachlan, Khari A. Edwards, David Johnson, Maite Tome, Sanjay Sharma, Mary N. Sheppard, Elijah R. Behr
Journal: Journal of the American College of Cardiology (2021)

Electrophysiological, imaging, and pathological studies have reported the presence of subtle structural abnormalities in hearts from patients with Brugada syndrome (BrS). However, data concerning disease involvement outside of the right ventricular outflow tract are limited. This study sought to characterize the presence and distribution of ventricular myocardial fibrosis in a cohort of decedents experiencing sudden cardiac death caused by BrS. The authors evaluated 28 whole hearts from consecutive sudden cardiac death cases attributed to BrS and 29 hearts from a comparator group comprised of noncardiac deaths (control subjects). Cardiac tissue from 6 regions across the right and left ventricle were stained with Picrosirius red for collagen and tissue composition was determined using image analysis software. Postmortem genetic testing was performed in cases with DNA retained for analysis. Of 28 BrS decedents (75% men; median age of death 25 years), death occurred in sleep or at rest in 24 of 28 (86%). The highest proportion of collagen was observed in the epicardial right ventricular outflow tract of the BrS group (23.7%; 95% CI: 20.8%-26.9%). Ventricular myocardium from BrS decedents demonstrated a higher proportion of collagen compared with control subjects (ratio 1.45; 95% CI: 1.22-1.71; P < 0.001), with no significant interactions with respect to sampling location or tissue layer. There was insufficient evidence to support differences in collagen proportion in SCN5A-positive cases (n = 5) when compared with control subjects (ratio 1.23; 95% CI: 0.75-1.43; P = 0.27). Brugada syndrome is associated with increased collagen content throughout right and left ventricular myocardium, irrespective of sampling location or myocardial layer.
Labour would guarantee mental health treatment in less than a month, says Starmer
Authors: Gareth Iacobucci
Journal: BMJ (2021)

A Labour government would introduce a new NHS target for patients to start receiving appropriate mental health treatment—not simply an initial assessment of needs—within a month of referral, the party’s leader has announced.

In his keynote speech on 29 September at the annual Labour Party conference in Brighton, Keir Starmer outlined his party’s plan to tackle the current crisis in mental health services, which he described as “one of the most urgent needs of our time.”

NHS England is currently consulting on new mental health waiting time targets to improve access to care,1 including a requirement for under 18s who present to community mental health services …
1492P A longitudinal cohort study on assessing the impact COVID-19 pandemic on the mental health of cancer care providers: Developing world scenario
Authors: A. Thaduri, A. Sehrawat, D.R. Poonia, A. Das, R. Kumar, A. Varghese, R. Kottayasamy Seenivasagam, P.K. Garg, M.K. Gupta, S. Agarwal
Journal: Annals of Oncology (2021)
Eliminating HIV transmission through breast milk from women taking antiretroviral drugs
Authors: Ameena E Goga, Philippe Van de Perre, Nobubelo Ngandu, Nicolas Nagot, Elaine J Abrams, Dhayendre Moodley, Rachel King, Jean-Pierre Molès, Witness Chirinda, Gabriella Scarlatti, Thorkild Tylleskär, Gayle G Sherman, Yogan Pillay, François Dabis, Glenda Gray
Journal: BMJ (2021)

Eliminating HIV transmission through breast milk from women taking antiretroviral drugs Ameena Goga and colleagues argue that frequent testing of maternal viral load is needed to eliminate HIV transmission through breast milk in low and middle income settings• The utility of additional complemen- tary interventions such as long acting maternal antiretroviral drugs, extended prophylaxis, broadly neutralising antibodies, or vaccines in infants whose mothers are receiving antiretroviral treatment needs further investigation.
165P Pathologic and immunohistochemical prognostic score in residual triple-negative breast cancer after neoadjuvant chemotherapy
Authors: S.M. Ilie, L. Arnould, N. Briot, I. Desmoulins, A. Hennequin, C. Kaderbhai, A. Bertaut, C. Coutant, S. Causeret, C. Loustalot, A. Ilie, V. Derangere, S. Ladoire
Journal: Annals of Oncology (2021)
Analyses of oligodontia phenotypes and genetic etiologies
Authors: Mengqi Zhou, Hong Zhang, Heather Camhi, Figen Seymen, Mine Koruyucu, Yelda Kasimoglu, Jung-Wook Kim, Hera Kim-Berman, Ninna M. R. Yuson, Paul J. Benke, Yiqun Wu, Feng Wang, Yaqin Zhu, James P. Simmer, Jan C-C. Hu
Journal: International Journal of Oral Science (2021)

Abstract Oligodontia is the congenital absence of six or more teeth and comprises the more severe forms of tooth agenesis. Many genes have been implicated in the etiology of tooth agenesis, which is highly variable in its clinical presentation. The purpose of this study was to identify associations between genetic mutations and clinical features of oligodontia patients. An online systematic search of papers published from January 1992 to June 2021 identified 381 oligodontia cases meeting the eligibility criteria of causative gene mutation, phenotype description, and radiographic records. Additionally, ten families with oligodontia were recruited and their genetic etiologies were determined by whole-exome sequence analyses. We identified a novel mutation in WNT10A (c.99_105dup) and eight previously reported mutations in WNT10A (c.433 G &gt; A; c.682 T &gt; A; c.318 C &gt; G; c.511.C &gt; T; c.321 C &gt; A), EDAR (c.581 C &gt; T), and LRP6 (c.1003 C &gt; T, c.2747 G &gt; T). Collectively, 20 different causative genes were implicated among those 393 cases with oligodontia. For each causative gene, the mean number of missing teeth per case and the frequency of teeth missing at each position were calculated. Genotype–phenotype correlation analysis indicated that molars agenesis is more likely linked to PAX9 mutations, mandibular first premolar agenesis is least associated with PAX9 mutations. Mandibular incisors and maxillary lateral incisor agenesis are most closely linked to EDA mutations.