tbuckley/cabot-search huggingface dataset:
Adoptive Therapy Using Sleeping Beauty Gene Transfer System and Artificial Antigen Presenting Cells to Manufacture T Cells Expressing CD19-Specific Chimeric Antigen Receptor
Authors: Partow Kebriaei, Helen Huls, Harjeet Singh, Simon Olivares, Matthew Figliola, Sourindra Maiti, Su Shihuang, Pappanaicken R Kumar, Bipulendu Jena, Marie Andree Forget, Sonny Ang, Jackson Rineka, Tingting Liu, Ian K. McNiece, Gabriela Rondon, Perry Hackett, William G. Wierda, Susan O'Brien, Michael J Keating, Hagop M. Kantarjian, Chitra M Hosing, Elizabeth J Shpall, Richard E. Champlin, Laurence JN Cooper
Journal: Blood (2014)
Integration of hepatitis B vaccination into national immunisation programmes
Authors: W J Edmunds, M Kane, P Van Damme, A Meheus
Journal: BMJ (1998)

Outcome of pregnancy in women with insulin dependent diabetes Centralisation of care leads to better outcomeEditor-The finding of a persistently poor outcome of pregnancy in women with insulin dependent diabetes in two (northern) English regions is an important statement of the problem. 1 2 Both studies provide figures and show outcomes that are no different from those widely reported in the past.Unfortunately, neither give evidence of any degree of centralisation of obstetric or diabetic care, with on-site neonatal intensive care, although this is a proved means of improving the outcome of pregnancy for diabetic mothers. 3 The St Vincent declaration guidelines on the outcome of pregnancy, referred to in the accompanying editorial (p 263), are based on the Scandinavian reports held up as examples of good practice and state that "an interdisciplinary team should provide centralized diabetic pregnancy care in a hospital treating at least 20-30 cases a year.Pregnant diabetic
Abstract P342: Predicting Low Pharmacy Refill Adherence in Elderly Patients with Uncontrolled Blood Pressure
Authors: Marie A Krousel-Wood, Cara Joyce, Elizabeth W Holt, Emily B Levitan, Adriana Dornelles, Larry S Webber, Paul Muntner
Journal: Circulation (2013)

Background:  Parsimonious self-report tools predicting pharmacy refill in patients with uncontrolled blood pressure could facilitate hypertension management in the elderly. We developed and evaluated a short self-report tool to predict low adherence via pharmacy refill in older patients with uncontrolled hypertension.   Methods:  Cross-sectional analyses of survey and administrative data from the Cohort Study of Medication Adherence among Older Adults (CoSMO) were conducted on 394 adults with uncontrolled blood pressure. We considered 164 self-reported candidate items for development of a prediction rule for low (   Results:  Participants were 33.0% black (130 of 394), 66.0% women (260 of 394), 23.4% with low MPR (92 of 394), and mean age of 76.6 ± 5.6 years. A 4-item self-report tool predicting pharmacy refill adherence showed moderate discrimination (C-statistic = 0.704, 95% CI = 0.683, 0.714) and good model fit (Hosmer-Lemeshow  x 2  P= 0.743 ). Sensitivity and specificity were 67.4% and 67.8%, respectively. The C-statistics for MMAS-8 and the Hill-Bone Compliance Scale were 0.665 (95% CI =0.632, 0.683) and 0.660 (95% CI = 0.622, 0.674), respectively.   Conclusion:  A 4-item self-report tool moderately discriminated low from high pharmacy refill adherers, and its test performance was comparable to existing 8- and 9-item adherence scales. Parsimonious tools to identify low adherers among patients with uncontrolled blood pressure may facilitate tailoring of interventions to improve blood pressure control in the elderly.
Abstract 13951: Myocardial Mechanics in Hypertrophic Cardiomyopathy: Correlations with Late Gadolinium Enhancement
Authors: Lynne K Williams, Christiane Gruner, Shemy Carasso, Bernd Wintersperger, Andrew Crean, Harry Rakowski
Journal: Circulation (2011)

Background: In hypertrophic cardiomyopathy (HCM), myocyte hypertrophy, fiber disarray, and interstitial fibrosis interfere with both systolic and diastolic myocardial mechanics despite clinically h...
Lung Volume and Its Variations
Authors: J. C. Meakins, R. V. Christie
Journal: Annals of Internal Medicine (1929)

Article1 November 1929Lung Volume and Its VariationsJ. C. MEAKINS, R. V. CHRISTIEJ. C. MEAKINS, R. V. CHRISTIEAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-3-5-423 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe statement that respiratory exchange in the lower branches of the bronchial tree, the bronchioles and the alveoli is carried on chiefly by diffusion, is probably correct up to a certain point. However, the importance of respiratory movements in the ventilation of the air sacs cannot be relegated to a rôle of minor importance. Without such movements the respiratory function fails to support life even under artificial conditions of enormously increased diffusion pressures. The efficiency of the ventilating system inaugurated by the respiratory movements is obviously most important in abnormal pulmonary conditions. On approaching the subject of pulmonary ventilation it...Bibliography1 VAN SLYKEBINGER DDCA: Journ. Exper. Med., 1923, xxxvii, 457. CrossrefGoogle Scholar2 GARVINLUNDSGAARDVAN SLYKE ACDD: Journ. Exper. Med., 1918, xxvii, 87 and 129. CrossrefGoogle Scholar3 BINGER CA: Journ. Exper. Med., 1923, xxxviii, 445. CrossrefGoogle Scholar4 LUNDSGAARDSCHIERBECK CK: Acta Med. Scandinavica, 1923, lviii, 541. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Montreal,*From the Department of Medicine, McGill University Clinic, Royal Victoria Hospital, Montreal.†Read before the Boston Meeting of the American College of Physicians, April 12, 1929. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLung Function in Congenital Heart DiseaseDie Bedeutung der Spirographie für die Beurteilung der Lungeninsuffizienz, speziell des EmphysemsDie Bedeutung der Spirographie für die Beurteilung der Lungeninsuffizienz, speziell des EmphysemsDisturbances in pulmonary function in mitral stenosis and left heart failurePathophysiologie der AtmungAsthma bronchialePathophysiologie der AtmungPulmonary Function in Rheumatic Heart Disease and Its Relation to Exertional Dyspnea in Ambulatory PatientsVentilatory studies in mitral stenosisTHE LUNG VOLUME IN LOW OUTPUT CARDIAC SYNDROMESThe Total Lung Volume and its Subdivisions: III.--Correlation with other Anthropometric DataThe Total Lung Volume and its Subdivisions. A Study in Physiological Norms: I. Basic Data 1 November 1929Volume 3, Issue 5Page: 423-429KeywordsAlveoliBronchiolesHospital medicineLungsVentilators ePublished: 1 December 2008 Issue Published: 1 November 1929 PDF downloadLoading ...
Transmission of Mycobacterium Tuberculosis Associated with Failed Completion of Treatment for Latent Tuberculosis Infection - Chickasaw County, Mississippi, June 1999-March 2002
Authors: T. Chamblee, D. Hartley, M. Holcombe, K. Parham, P. Upchurch, R. M. Webb, Alyssa G. Robillard, L. Diem, B. Metchock, N. DeLuca, P. D. McElroy, T. Navin, W. Walton, P. K. Dewan
Journal: MMWR Morbidity and Mortality Weekly Report (2003)
Abstract 17926: Cardiac Amyloid Deposition is Common in Elderly Patients with Heart Failure and Preserved Ejection Fraction
Authors: Sultan A Mirzoyev, William D Edwards, Selma F Mohammed, Janis L Donovan, Veronique L Roger, Donna R Grogan, Margaret M Redfield
Journal: Circulation (2010)

Introduction: Heart failure (HF) with preserved ejection fraction (HFpEF) is predominantly a disease of the elderly. The pathophysiology of HFpEF is complex with ventricular and vascular dysfunctio...
Quality of care has improved
Authors: B D W Harrison, D N L Ralphs
Journal: BMJ (1995)

Dosage ofangiotensin converting enzyme inhibitorsEDrrOR,-A L Clark and A J S Coats highlight the common problem of suboptimal doses of angio- tensin converting enzyme inhibitors being pre- scribed for patients with impaired left ventricular function.'Their paper, however, contains an important error, and when this is corrected the situation is seen to be even worse than they state.Clark and Coats suggest that the optimum dose of captopril to reduce mortality is 25 mg twice daily.This is not the case.The study they cite in support of this dose did not show a significant reduction in mortality.The dose of captopril most clearly shown to reduce mortality is 50 mg three times daily, and most studies of heart failure show- ing an improvement in symptoms and exercise tolerance with captopril have used doses at least as large as this.23
James Rowland Russell
Authors: R. R. P. Mills
Journal: BMJ (2015)

Educated at Radley, James Rowland Russell (“Jim”) studied medicine at Clare College, Cambridge. A committed Christian throughout his life, he set up a support group for disabled children in Cambridge and spent time working in a leper colony in Africa before qualifying from the Middlesex Hospital Medical School. It was soon after, as a house surgeon to Sir Thomas Holmes Sellors at the Middlesex, that he met his wife, Glenys, a Middlesex nurse. The couple shared 49 years together and were planning their golden wedding anniversary on …
Adherence to peak flow monitoring
Authors: Ann-Louise Caress, Karen Luker, Kinta Beaver, Ashley Woodcock
Journal: BMJ (2002)

Road traffic injuries are a global public health problemEditor-Road traffic crashes and their sequelae are a scourge in all societies, both developed and developing.Each year over a million people are killed in road traffic collisions worldwide and some 10 million people are injured or disabled by these events, 1 predominantly in low and middle income countries. 2 Despite what is known about road traffic crashes and their health consequences, policymakers worldwide show little awareness of their contribution to the burden of disease; consequently they are neglected in service and policy.At the same time there has been limited funding, particularly in low and middle income countries, for traffic related research 3 even though these injuries drain developing economies of 1-2% of gross domestic product (about $100 bn) each year, or twice the total development aid received worldwide by developing countries. 4 The critical issue is that road traffic injuries can be prevented.Many effective strategies have been identified in developed countries, but since the type of traffic injuries in developing countries differ greatly from those in developed countries, the prevention strategies, technologies, and policies cannot simply be exported.They require specific testing and appropriate modification to ensure their effectiveness in developing societies.The World Health Organization, as the lead coordinating agency for international public health, is guiding a science based programme of activities in the prevention of road traffic injury.In 2001 its department of injuries and violence prevention, together with partners, developed a multidisciplinary five year global strategy for this (www.who.int/violence_injury_prevention/index.html).This strategy takes into consideration competing needs and expectations, and limited resources in many countries, and addresses long term sustainable goals.The Global Forum for Health Research and the WHO are supporting an initiative to promote appropriate research in Africa, Asia, and Latin America (see www. globalforumhealth.org/pages/index.asp).This North-South collaborative effort is embarking on an ambitious research agenda for the prevention of road traffic injuries.Complementarily, another initiative, led by the Harvard Center for Population and Development Studies and cosponsored by the WHO, addresses the problem of health equity and road traffic injuries.An alliance of partners will help 10 developing countries to develop appropriate policies and interventions over five years.Dedicating an issue of the BMJ to road traffic injuries is a welcome step in the acknowledgement of this global public health problem.It is also a call for partners around the world to confront the growing epidemic and save lives.
Abstract 3963: Deficiency Of TGF-{beta} Signaling In CD11c Positive Dendritic Cells, Macrophages And NK Cells Accelerates Atherosclerosis By Inducing Inflammatory Cell Influx
Authors: Dirk Lievens, Anna-Karin Robertson, Linda Beckers, Yasmina Laouar, Mats Rudling, Erik A Biessen, Mat J Daemen, Richard A Flavell, Esther Lutgens
Journal: Circulation (2008)
Abstract 2406: Coronary Microvascular Function as a Target for Prevention of Systolic Heart Failure in Chronic Valvular Heart Disease: Aortic Regurgitation versus Mitral Regurgitation
Authors: Hideki Okui, Shuichi Hamasaki, Sanemasa Ishida, Masakazu Ogawa, Keishi Saihara, Koji Orihara, Takuro Shinsato, Takuro Kubozono, So Kuwahata, Yuichi Ninomiya, Shouji Fujita, Takuro Takumi, Akiko Yoshikawa, Yasuhisa Iriki, Chuwa Tei
Journal: Circulation (2008)

Background: The coronary microvascular vasodilating function is an important determinant of patient outcomes in a number of clinical settings, including coronary artery disease, hypertensive heart disease, or cardiomyopathy. However, the characteristics or the implication of coronary microcirculation in valvular heart disease has not been fully elucidated. The present study was designed to assess coronary vasodilating function and its effects on systolic function in patients with aortic regurgitation (AR) and mitral regurgitation (MR). Methods: Forty-four consecutive patients (66 yrs) with moderate to severe AR and 45 consecutive patients with moderate to severe MR (64 yrs) were enrolled for this study. All patients were free of coronary artery stenosis. Fifty-one age-matched patients without underlying cardiovascular disease served as controls. Endothelium-dependent and endothelium-independent vasodilating function of resistance coronary artery were assessed by coronary blood flow (CBF) response to acetylcholine and papaverine, respectively. Left ventricular ejection fraction (LVEF) was determined by echocardiography as an indicator of systolic function. Results: In patients with AR, both %change in CBF response to acetylcholine and papaverine were significantly lower than controls (32 ± 61 vs 64 ± 84, 172 ± 87 vs 268 ± 105, p &lt; 0.05, p &lt; 0.01, respectively). Further, %change in CBF response to acetylcholine positively correlated with LVEF (r = 0.45, p &lt; 0.01). In patients with MR, %change in CBF response to papaverine was significantly lower than controls (221 ± 123 vs 268 ± 105, p &lt; 0.05), but %change in CBF response to acetylcholine was comparable with controls. Moreover, neither %change in CBF response to acetylcholine nor CBF response to papaverine had significant correlation with LVEF. Conclusion: In patients with AR, both endothelium-dependent and endothelium-independent vasodilating function of resistance coronary artery were deteriorated. Further, endothelium-dependent vasodilating function may be associated with left ventricular systolic function. Our findings indicate coronary microvascular endothelial dysfunction as a potential target for prevention of systolic heart failure in patients with AR.
Better standards of care will reduce morbidity and mortality
Authors: E. O'Donnell, D. Somerset
Journal: BMJ (1995)

of cardiac death.That would be, as Bassan writes, the height of folly.Instead we recommended further evaluation of patients in whom monitoring performed for clinical reasons shows abnormal findings (described in our paper).As we wrote, the benefit of managing silent ischaemia in elderly people is unclear.Nevertheless, if silent ischaemia is diagnosed it is clinically and ethically accepted, even in elderly patients, that risk factors should be controlled and treatment with aspirin and even fi blockers considered.Specific treatment of the marker, arrhythmia, would be unwise and certainly ineffective.An important question is whether these markers are also valid in middle aged people.Bassan argues that the markers were defined arbitrarily.This is not true.All clinically relevant arrhythmias shown by Holter monitoring were included in the analysis, and the cut off points for abnormal findings were based on the criteria used in other studies attempting to find prognostic markers.
IL-33 reduces the development of atherosclerosis
Authors: Ashley M. Miller, Damo Xu, Darren L. Asquith, Laura Denby, Yubin Li, Naveed Sattar, Andrew H. Baker, Iain B. McInnes, Foo Y. Liew
Journal: The Journal of Experimental Medicine (2012)

The authors regret that Fig. 1 B in this paper was incorrect, as two bands were inadvertently mixed up during figure compilation. None of the conclusions presented in the paper were affected by this error. The corrected Figure 1 is shown below, and the html and pdf versions of the article have been updated.
Blood Pressure in Early Autosomal Dominant Polycystic Kidney Disease
Authors: A. Lianne Messchendorp, Ron T. Gansevoort
Journal: New England Journal of Medicine (2015)

To the Editor: In the Halt Progression of Polycystic Kidney Disease (HALT-PKD) study, Schrier et al. (Dec.11 issue) 1 randomly assigned patients with early-stage autosomal dominant polycystic kidney disease (ADPKD) to either a standard blood-pressure target or a low blood-pressure target.The low blood-pressure target was associated with a slower increase in total kidney volume, but not with an overall change in the estimated glomerular filtration rate (GFR).The latter finding might be viewed as being disappointing.However, we would caution that the institution of strict blood-pressure control will result in an acute, hemodynamic, but reversible decrease in the estimated GFR.A recent scientific workshop sponsored by the U.S. National Kidney Foundation and the Food and Drug Administration concluded that this acute effect is not indicative of irreversible loss of nephrons. 2Accordingly, rather than using the baseline estimated GFR, we would suggest comparing only on-treatment slopes of the estimated GFR.Such an analysis does show a benefit associated with the low blood-pressure target (P = 0.05). 1 Since a decrease in the estimated GFR is a late phenomenon in many patients with ADPKD, 3 a subgroup analysis of on-treatment estimated GFR slopes with the use of forest plots would be of interest, since it might hint at whether certain subgroups of patients with earlystage disease might benefit from a low bloodpressure target.
Ads: "Unselling" the cigarette
Authors: M. Wakefield
Journal: BMJ (1999)

For decades, advertising agencies in the United States have been willing accomplices in promoting the sale of cigarettes. Years ago, agencies lauded their tobacco company accounts as prime evidence of their creative ability and competitive edge. These accounts were considered to be pearls, as valuable as those with major car manufacturers, soft drinks producers, breweries, and other free spending marketers of mass consumer products. But now all that is changing.

Although tobacco marketing still represents a huge source of revenue for agencies, a sizeable countertrend is building as more funds are becoming available for what might be described as the “unselling of the cigarette.” Alex Bogusky, partner and creative director for Crispin Porter and Bogusky in Coral Gables, Florida, told the New York Times : “The reason for cigarettes being among the most powerful brands in America …
Injectable microcryogels reinforced alginate encapsulation of mesenchymal stromal cells for leak-proof delivery and alleviation of canine disc degeneration
Authors: Yang Zeng, Chun Chen, Wei Liu, Qinyouen Fu, Zhihua Han, Yaqian Li, Siyu Feng, Xiaokang Li, Chunxiao Qi, Jianhong Wu, Deli Wang, Christopher Corbett, Barbara P. Chan, Dike Ruan, Yanan Du
Journal: Biomaterials (2015)
A Workflow to Investigate Exposure and Pharmacokinetic Influences on High-Throughput <i>in Vitro</i> Chemical Screening Based on Adverse Outcome Pathways
Authors: Martin B. Phillips, Jeremy A. Leonard, Christopher M. Grulke, Daniel T. Chang, Stephen W. Edwards, Raina Brooks, Michael-Rock Goldsmith, Hisham El-Masri, Yu-Mei Tan
Journal: Environmental Health Perspectives (2015)

Adverse outcome pathways (AOPs) link adverse effects in individuals or populations to a molecular initiating event (MIE) that can be quantified using in vitro methods. Practical application of AOPs in chemical-specific risk assessment requires incorporation of knowledge on exposure, along with absorption, distribution, metabolism, and excretion (ADME) properties of chemicals.We developed a conceptual workflow to examine exposure and ADME properties in relation to an MIE. The utility of this workflow was evaluated using a previously established AOP, acetylcholinesterase (AChE) inhibition.Thirty chemicals found to inhibit human AChE in the ToxCast™ assay were examined with respect to their exposure, absorption potential, and ability to cross the blood-brain barrier (BBB). Structures of active chemicals were compared against structures of 1,029 inactive chemicals to detect possible parent compounds that might have active metabolites.Application of the workflow screened 10 "low-priority" chemicals of 30 active chemicals. Fifty-two of the 1,029 inactive chemicals exhibited a similarity threshold of ≥ 75% with their nearest active neighbors. Of these 52 compounds, 30 were excluded due to poor absorption or distribution. The remaining 22 compounds may inhibit AChE in vivo either directly or as a result of metabolic activation.The incorporation of exposure and ADME properties into the conceptual workflow eliminated 10 "low-priority" chemicals that may otherwise have undergone additional, resource-consuming analyses. Our workflow also increased confidence in interpretation of in vitro results by identifying possible "false negatives."Phillips MB, Leonard JA, Grulke CM, Chang DT, Edwards SW, Brooks R, Goldsmith MR, El-Masri H, Tan YM. 2016. A workflow to investigate exposure and pharmacokinetic influences on high-throughput in vitro chemical screening based on adverse outcome pathways. Environ Health Perspect 124:53-60; http://dx.doi.org/10.1289/ehp.1409450.