tbuckley/cabot-search huggingface dataset:
Nivolumab plus ipilimumab (N+I) in patients (pts) with colorectal cancer (CRC) with high tumor mutational burden (hTMB): Results from the Targeted Agent and Profiling Utilization Registry (TAPUR) study.
Authors: Gina M. Vaccaro, Michael Rothe, Pam K. Mangat, Elizabeth Garrett-Mayer, Jimmy J. Hwang, Olatunji B. Alese, Maged F. Khalil, Muhammad Khurram Hameed, Herbert Leon Duvivier, Timothy Lewis Cannon, Gina N. Grantham, Susan Halabi, Richard L. Schilsky
Journal: Journal of Clinical Oncology (2022)

107 Background: TAPUR is a phase II basket study evaluating the anti-tumor activity of commercially available targeted agents in pts with advanced cancers with genomic alterations. Results in a cohort of CRC pts with hTMB treated with N+I are reported. Methods: Eligible pts had advanced CRC, no available standard treatment options, measurable disease, ECOG performance status (PS) 0-2, adequate organ function and no prior immune checkpoint inhibitor treatment. PDL-1 expression testing was not required. Genomic testing was performed in CLIA-certified, CAP-accredited site selected labs. hTMB was defined a priori as ≥9 mutations/megabase (Muts/Mb) reported by a FoundationOne test (n=7) or other tests (n=5) if approved by the Molecular Tumor Board. Pts received N 1 mg/kg IV every 3 weeks (wks) for 4 doses in combination with I 3 mg/kg every 3 wks for 4 doses. N was then continued at 240 mg every 2 wks or 480 mg every 4 wks until disease progression. Primary endpoint was disease control (DC), defined as complete (CR) or partial (PR) response, or stable disease at 16+ wks (SD 16+). Simon 2-stage design tested the null DC rate of 15% vs. 35% (power = 0.85; α = 0.10). If ≥2 of 10 pts in stage 1 has DC, 18 more pts are enrolled; otherwise, the study stops for futility. If ≥7 of 28 pts has DC, the null DC rate is rejected. Secondary endpoints were progression-free survival (PFS), overall survival (OS) and safety. Results: 12 pts (9 male) with CRC with hTMB in tissue biopsy were enrolled from February 2018 to May 2020; 2 pts were not evaluable and excluded from efficacy analyses. All pts were evaluated for toxicity. TMB ranged from 9 to 233 Muts/Mb (median 13). Demographics and outcomes are summarized in the table below. Tumor microsatellite (MS) status was reported stable for 11 pts and indeterminate for 1 pt. 1 PR (88.1 wks duration, tumor 11 Muts/Mb, MS stable, PDL-1 expression not reported, KRAS mutant) and 0 pts with SD16+ were observed for a DC and OR rate of 10% (95% CI: 0%, 45%); the null DC rate of 15% was not rejected (p=0.80) and the cohort closed due to futility. 4 pts had at least one grade 3-4 adverse or serious adverse event (AE/SAE) at least possibly related to N+I including myasthenia gravis, diarrhea, glucose intolerance, hyperglycemia, and small intestinal obstruction. Conclusions: Combination therapy with N+I does not have sufficient clinical activity in pts with MS stable, hTMB CRC for further evaluation in this pt population. Other treatments should be considered for these pts, including treatments offered in clinical trials. Clinical trial information: NCT02693535. [Table: see text]
Esmond R. Long dies
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Experimentation in children
Authors: E. J. Rourke
Journal: JAMA (1970)

<h3>To the Editor:—</h3> Regarding "Allergy to Local Anesthetics" (<b>207:</b>356, 1969) and subsequent correspondence in LETTERS, I have found a useful alternative in those situations in which there is a history of "caine allergy." When the need for prompt therapy exists, injectable diphenhydramine hydrochloride (Benadryl) produces sufficient local anesthesia to permit most small surgical procedures, aspirations, and local infiltrations. While this is noted in major texts of pharmacology, it is not known to the practicing physicians generally.
Clinical implications of the no-reflow phenomenon. A predictor of left ventricular remodeling in reperfused acute myocardial infarction Paolo Colonna, Roberta Montisci, Marco Corda, Christian Cadeddu, Lijun Chen, Enrico Onnis, Luigi Meloni, Sabino Iliceto. Department of Cardiovascular and Neurological Sciences, University of Cagliari, Cagliari, Italy
Journal: Journal of the American College of Cardiology (2001)
Abstract P290: Maternal Aerobic Exercise Intervention Improves Fetal Heart and Growth Measures
Authors: Linda E May, Edward Newton, Diana M Strickland, Christy M Isler, Lisa Chasan-Taber, George A Kelley, R D Steed, Joseph A Houmard, Xiangming Fang
Journal: Circulation (2018)

Introduction: Self-reported maternal exercise is associated with improved heart and body size measures in the fetus. Currently, there is a gap in understanding how regular maternal aerobic exercise at recommended levels (150 min/wk) for pregnancy influence heart and body size in utero. Hypothesis: We assessed the hypothesis that offspring of women randomized to aerobic exercise will have lower heart rate (HR), higher ejection fractions (EF), and lighter fetal weight than offspring of women in the control group. Methods: Healthy pregnant women were randomly assigned to aerobic exercise or no intervention. Women performed aerobic activity at a moderate intensity for 150 min/wk from 16 weeks until delivery. Maternal demographics (age, pre-pregnancy BMI) as well as other activities were self-reported. Based on type and intensity, activities were converted to METs and then combined to yield METmin per week (METs X frequency per week X duration in minutes). A sonographer blinded to group assignment recorded fetal ultrasound. Data from 27 pregnancies (16 exercise, 11 control) were analyzed. To compare differences between groups (Active only=A; Quiet only=Q) independent t -tests were performed while regression analysis was conducted to determine predictors of fetal HR, our primary outcome. Results: Of the 16 exercisers, 6 were excluded (compliance 51-74%); the remaining 10 had &gt;80% compliance. There were no group differences in maternal demographics, i.e., age and pre-pregnancy BMI. All values were in the normal range for fetal heart and body size measures. While not statistically significant, there was trend for fetal HR to be lower in exercisers (p=0.14) while aortic (p=0.05) and pulmonary (p=0.22) diameter, right ventricular (RV) EF (p=0.17), and left ventricular (LV) EF (p=0.18) were slightly higher compared to controls. In the A state , the female HR of exercisers were lower (p=0.05), while male left ventricular (LV) EF (p=0.006), and all fetuses right ventricular (RV) EF (p=0.07) were increased relative to same gender controls. In the Q state , female aortic diameter (p=0.11) and all fetuses’ pulmonary diameter (p=0.04) were increased in exercisers relative to same gender controls. Exercise level during pregnancy was a significant predictor of fetal HR (R 2 =0.10; p=0.01). Fetal head to abdominal circumference ratio was appropriate in exercisers (1.0±0.1) relative to control (0.985±0.1) fetuses (p=0.09). The fetuses of exercisers were slightly lighter relative to fetuses of controls (p=0.20). Conclusion: These preliminary data support the positive influence of aerobic exercise at recommended levels on fetal health outcomes during pregnancy.
Detecting Deteriorating Patients in the Hospital: Development and Validation of a Novel Scoring System
Authors: Marco A. F. Pimentel, Oliver C. Redfern, James Malycha, Paul Meredith, David Prytherch, Jim Briggs, J. Duncan Young, David A. Clifton, Lionel Tarassenko, Peter J. Watkinson
Journal: American Journal of Respiratory and Critical Care Medicine (2021)

Late recognition of patient deterioration in hospital is associated with worse outcomes, including higher mortality. Despite the widespread introduction of early warning score (EWS) systems and electronic health records, deterioration still goes unrecognized.
The FDA
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TCT-65 Two-Year Outcomes in Real-World Patients Treated With a Thin-Strut, Platinum-Chromium, Everolimus-Eluting Stent in the PROMUS Element Plus US Post-Approval Study (PE-Plus PAS)
Authors: David Kandzari, A. Thomas Siachos, Luis F. Tami, Bruce Watt, Randall Goodroe, Thomas K. Pow, Roger Hill, Amir Haghighat, Thomas Christen, Dominic J. Allocco, Keith D. Dawkins
Journal: Journal of the American College of Cardiology (2015)
ESCMID COVID-19 living guidelines: drug treatment and clinical management: author's reply
Authors: Michele Bartoletti, Ozlem Azap, Aleksandra Barac, Linda Bussini, Onder Ergonul, Robert Krause, Alejandro Martín-Quirós, José Ramon Paño-Pardo, Nicholas Power, Marcella Sibani, Balint Szabo, Sotirios Tsiodras, Ines Zollner-Schwetz, Jesús Rodriguez-Baño
Journal: Clinical Microbiology and Infection (2022)
Highlights
Journal: JAMA Psychiatry (2019)

There has been a move from categorical toward spectrum-based definitions of autism accompanied by steady increases in its prevalence.In a meta-analysis, Rodgaard and colleagues investigated 11 meta-analyses with data from 27 723 individuals examining group differences on 7 neurocognitive constructs and found downward temporal trends for effect size for all constructs without a similar trend in studies of schizophrenia.Reduction in differences between individuals with and without autism may be owing to changes in the definition of autism.In an Editorial, Harris discusses implications for the field.
Re: Yu Xiao, Kaiyu Qian, Yongwen Luo, et al. Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Renal Failure Patients: A Potential Covert Source of Infection. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.03.025
Authors: Peng He, Xiaohui Wang, Hao Li
Journal: European Urology (2020)
A nomogram for predicting cancer specific survival (CSS) in patients with pathological T3N0M0 (pT3N0M0) rectal cancer.
Authors: Shuang Liu, ShaoYan Xi, Xiao-Jun Wu, Peiqiang Cai, Pei-Rong Ding, Gong Chen, Zhi-Zhong Pan, Yuan-Hong Gao, Weiwei Xiao
Journal: Journal of Clinical Oncology (2022)

113 Background: Preoperative chemoradiotherapy followed by total mesorectal excision (TME) surgery has been widely adopted as the standard treatment for stage II-III rectal cancers. However, the role of adjuvant chemotherapy in pathological T3N0M0 (pT3N0M0) patients remains controversial. A reliable prognostic model is needed to discriminate the high-risk patients from the low-risk patients, and optimize adjuvant chemotherapy treatment decisions by predicting the likelihood of adjuvant chemotherapy benefit for the target population. Methods: We gathered and analyzed 276 patients in Sun Yat-Sen University Cancer Center from March 2005 to December 2011. All patients underwent total mesorectal excision, without preoperative therapy, and were pathologically proven pT3N0M0 rectal cancer. LASSO regression model was used for variable selection and risk factor prediction. Multivariable cox regression was used to develop the predicting model. Optimum cut-off values were determined using X-Tile plot analysis. The 10-fold cross validation was adopted to validate the model. The performance of the nomogram was evaluated with its calibration, discrimination and clinical usefulness. Results: A total of 188 patients (68.1%) had adjuvant chemotherapy and no patients had adjuvant radiotherapy. Age, carbohydrate antigen 19-9 [CA199], monocyte percentage [MONO%], lymph node dissection numbers [LNDs] and nerve invasion were identified as significantly associated variables that could be combined for an accurate prediction risk of CSS for pT3N0M0 patients. The model adjusted for CSS showed good discrimination with a C-index of 0.723 (95% CI = 0.652 to 0.794). The calibration curves showed that the nomogram adjusted for CSS was able to predict 3-, 5-, and 10-year CSS accurately. The corresponding predicted probability was used to stratify high and low-risk patients. Adjuvant chemotherapy improved survival rate in the low-risk patients (HR = 0.338, 95% CI: 0.135 to 0.848, P = 0.021), while it did not exhibit a significant benefit in the high-risk patients. Conclusions: The nomogram effectively predicts CSS in patients with pT3N0M0 rectal cancer, which can be conveniently used in clinical practice. Adjuvant chemotherapy may improve overall survival in the low-risk patients. But the benefit of adjuvant chemotherapy was not seen in the high-risk patients.
Error in Abstract and Results
Journal: JAMA Surgery (2021)

Lorraine I. Kelley-Quon, MD, MSHS; Matthew G. Kirkpatrick, PhD; Robert L. Ricca, MD; Robert Baird, MD; Calista M. Harbaugh, MD, MS; Ashley Brady, PA-C; Paula Garrett, RN; Hale Wills, MD, MS; Jonathan Argo, MD; Karen A. Diefenbach, MD; Marion C.W. Henry, MD; Juan E. Sola, MD; Elaa M. Mahdi, MD, MPH; Adam B. Goldin, MD, MPH; Shawn D. St Peter, MD; Cynthia D. Downard, MD, MMSc; Kenneth S. Azarow, MD; Tracy Shields, MSIS; Eugene Kim, MD
n−3 Fatty Acids in Patients with Multiple Cardiovascular Risk Factors
Authors: Gemma Nassta, J Richard, P Michelle
Journal: New England Journal of Medicine (2013)

corrections ble with freezing.Freeze sensitivity is a recognized problem in some vaccines, such as tetanus toxoid and hepatitis B, which lose potency when exposed to subzero temperatures, as occurs during transit in cold boxes. 3 We conducted a study to determine whether the freezing of oxytocin ampules, which may occur inadvertently during transport or storage, adversely affects the oxytocin content.Glass ampules of synthetic oxytocin (Syntocinon) containing 10 IU of oxytocin per milliliter were stored for up to 7 days at temperatures of -5°C and -20°C and on ice and on dry ice, with a control sample maintained at 4°C.We also subjected ampules to five freeze-thaw cycles in each of these conditions.The amount of oxytocin remaining in the sample after freezing or after undergoing freeze-thaw cycles was determined with the use of a validated liquid chromatography-triple quadrupole mass spectrometry assay.For both the 7-day storage period at three different temperatures and the 5-day period during which samples underwent multiple cycles of freezing and thawing, we performed a least-squares regression analysis in which the percentage of oxytocin remaining was measured against time (or cycle number).We found no significant changes in the concentration of oxytocin as compared with that in the set of control samples (Fig. 1).These results should reassure health care workers and skilled birth attendants that oxytocin ampules can be safely used even if they have been temporarily frozen during transportation or storage.
Error in Methods and Table
Authors: Ashley Choi, Hui-Jie Lee, Matthew Hartwig
Journal: JAMA Cardiology (2020)

Eric Kaplovitch, MD; John W. Eikelboom, MBBS, MSc; Leanne Dyal, MSc; Victor Aboyans, MD, PhD; Maria Teresa Abola, MD; Peter Verhamme, MD; Alvaro Avezum, MD, PhD; Keith A. A. Fox, MBChB; Scott D. Berkowitz, MD; Shrikant I. Bangdiwala, PhD; Salim Yusuf, MBBS, DPhil; Sonia S. Anand, MD, PhD
Endoscopy International Open – recently published
Journal: Endoscopy (2020)

Comment on:EUS-directed transgastric endoscopic retrograde cholangiopancreatography versus laparoscopic-assisted ERCP versus deep enteroscopy-assisted ERCP for patients with RYGBEndosc Int Open 2020; 08(07): E877-E882DOI: 10.1055/a-1164-6282Comment on:Comparison of dissection speed during colorectal ESD between the novel Multiloop (M-loop) traction method and ESD methods without tractionEndosc Int Open 2020; 08(07): E840-E847DOI: 10.1055/a-1161-8596Comment on:Endoscopic treatment of Zenkerʼs diverticulum by complete septotomy: initial experience in 19 patientsEndosc Int Open 2020; 08(07): E885-E890DOI: 10.1055/a-1153-8985
Proton vs photon radiation therapy for glioblastoma: Maximizing information from trial
Authors: Ivan R Vogelius, Søren M Bentzen
Journal: Neuro-Oncology (2021)

Evidence from randomized controlled trials of the comparative effectiveness of proton (PT—proton radiotherapy) vs photon (IMRT—intensity-modulated radiotherapy) radiation therapy remains in short supply. Therefore, it is important that we learn as much as possible from the few trials that have been successfully completed. We eagerly awaited the full report1 from the MD Anderson Cancer Center randomized phase II trial of neurocognitive failure (NCF) after protons vs photons in patients with newly diagnosed glioblastoma (GBM), first published in abstract form in 2017.2 While we applaud our colleagues for their efforts, we do feel that additional insights from the dataset could be beneficial for interpreting the trial outcome. The intention-to-treat (ITT) principle asserts that the effect of a treatment policy can be best assessed “by evaluating on the basis of the intention to treat a subject rather than the actual treatment given.” 3 While 90 patients were randomized, the analysis set only comprised 67 patients, PT (n = 28) and IMRT (n = 39). Thus, the analysis is not consistent with the ITT principle and should not be labeled as such. It is in essence a per-protocol analysis and the authors are encouraged to supplement with the outcome of a proper ITT analysis.
Married.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rapid Assessment of Injuries Among Survivors of the Terrorist Attack on the World Trade Center—New York City, September 2001
Journal: JAMA (2002)

On September 11, 2001, a jet aircraft crashed into the north tower of the World Trade Center (WTC) in lower Manhattan. Minutes later, a second aircraft crashed into the south tower. The impact, fires, and subsequent collapse of the buildings resulted in the deaths of thousands of persons. The precise number and causes of deaths could not be assessed in the immediate aftermath of the attack; however, data were available on the frequency and type of injuries among survivors (Figure 1). In previous disasters, such information assisted in characterizing type and severity of injuries and the health-care services needed by survivors. To assess injuries and use of health-care services by survivors, the New York City Department of Health (NYCDOH) conducted a field investigation to review emergency department (ED) and inpatient medical records at the four hospitals closest to the crash site and a fifth hospital that served as a burn referral center. This report summarizes findings of that assessment, which indicated that the arrival of injured persons to this sample of hospitals began within minutes of the attack and peaked 2 to 3 hours later. Among 790 injured survivors treated within 48 hours, approximately 50% received care within 7 hours of the attack, most for inhalation or ocular injuries; 18% were hospitalized. Comprehensive surveillance of disaster-related health effects is an integral part of effective disaster planning and response.
The 10th anniversary of MXenes: Challenges and prospects for their surface modification toward future biotechnological applications
Authors: Aleksandra Szuplewska, Dominika Kulpińska, Michał Jakubczak, Artur Dybko, Michał Chudy, Andrzej Olszyna, Zbigniew Brzózka, Agnieszka M. Jastrzębska
Journal: Advanced Drug Delivery Reviews (2022)