tbuckley/cabot-search huggingface dataset:
Regional myocardial free fatty acid extraction in normal and ischemic myocardium.
Authors: KVyska, H JMachulla, WStremmel, DFassbender, W HKnapp, GNotohamiprodjo, UGleichmann, HMeyer, E JKnust, RKörfer
Journal: Circulation (1988)

The rate constant for free fatty acid influx (k1) was studied in normal and ischemic myocardium. In 15 normal subjects and 30 patients with coronary artery disease, 201Tl and 15-(p-123I-iodophenyl)-pentadecanoic acid (IPPA) were administered during exercise under fasting conditions and at rest. In 10 patients, the study was repeated after percutaneous transluminal coronary angioplasty; in three patients, the study was repeated after infarction. The initial accumulation of IPPA, related to that of 201Tl (both background and crossover corrected), was used for determinations of the regional rate constant of IPPA influx into myocardial tissue (k1*). In normal subjects, no significant differences in k1* between major myocardial segments were found; the average value of k1* was 0.57 +/- 0.13/min (mean +/- SD) at rest and 0.42 +/- 0.06/min at exercise (average workload, 123 +/- 47 W). With increasing free fatty acid plasma concentration and perfusion, free fatty acid influx increased in a saturable fashion. The ...
Tropical and Geographical Medicine.
Journal: Annals of Internal Medicine (1991)

There is little doubt that this new 1,128 page publication is the most sig¬ nificant contribution to tropical and geographical medical literature in re¬ cent years. Warren and Mahmoud took on the unenviable task of collecting, collating, and editing the works of 153 contributors, most of whom are inter¬ nationally recognized experts in their field. The text is divided into five parts. The opening chapter, Clinical and Biological Considerations in the Ap¬ proach to Tropical Medicine, contains sections on a clinical problem-oriented approach, genetics, parasitism, and nutrition. Subsequent sections cover specific protozoan disease, metazoan disease, viral and chlamydial disease, bacterial, spirochetal, and Rickettsial disease, fungal disease, nutritional disease, and epidemiology and health
Diurnal variation of tissue-type plasminogen activator and its rapid inhibitor (PAI-1).
Authors: PAngleton, W LChandler, GSchmer
Journal: Circulation (1989)

Previous studies have shown that overall fibrinolytic activity in blood follows a diurnal rhythm with a peak in the morning and a trough in the evening. The purpose of this study was to determine which fibrinolytic factor(s) was responsible for this diurnal rhythm. Resting and postvenous occlusion tissue-type plasminogen activator (t-PA) activity, resting t-PA antigen, and resting plasminogen activator inhibitor 1 (PAI-1) activity were measured in the morning and evening in 33 healthy men (mean age, 31 years) and in 15 patients (mean age, 57 years) with previous myocardial infarction or unstable angina. PAI-1 activity and t-PA antigen were significantly higher (p less than 0.01) in the morning compared with the evening in controls and patients. In contrast, resting t-PA activity was significantly lower in the morning (p less than 0.01) in both groups and was inversely correlated with PAI-1 activity (r = -0.57, p less than 0.0001). Postvenous occlusion t-PA activity and t-PA capacity were not significantly...
Atp Tests After Manual Cleaning Do Not Predict The Presence Of Microorganisms On Duodenoscopes And Linear Echoendoscopes After High Level Disinfection
Authors: J Kwakman, A Rauwers, M Vos, M Bruno
Journal: Endoscopy (2021)

Aims Microbiological culturing is the gold standard in monitoring contamination of endoscopes, but has a considerable turnaround time. Adenosine triphosphate (ATP) tests promise to detect any biological material on endoscopes quickly, however, their reliability to detect contamination is not conclusively proven. We investigated the value of ATP tests after manual cleaning to predict the presence or absence of microorganisms shown by culture after high level disinfection (HLD) in duodenoscopes and linear echoendoscopes (DLE).
The Place Of Endoscopic Variceal Band Ligation In The Treatment Of Children With Prehepatic Portal Hypertension
Authors: D Voroniak, O Godik, I Kolomoiets, O Dubrovin
Journal: Endoscopy (2021)

Aims The bleeding from esophageal is one of the most dangerous complications in children with prehepatic portal hypertension (PH). The literature sources systematization shows that the question of choosing the variceal bleeding (VB) prevention optimal method in children remains debatable. The main goal of our study was to determine the optimal management for the VB preventive treatment in children with prehepatic PH.
Dietary cod-liver oil improves endothelium-dependent responses in hypercholesterolemic and atherosclerotic porcine coronary arteries.
Authors: HShimokawa, P MVanhoutte
Journal: Circulation (1988)

This study examined the effects of dietary supplementation with cod-liver oil on impaired endothelium-dependent relaxations in hypercholesterolemia and in atherosclerosis in porcine coronary arteries. Sixteen male Yorkshire pigs underwent balloon endothelium removal of the left coronary arteries and were fed a 2% high-cholesterol diet for 10 weeks, with or without dietary supplementation of cod-liver oil (30 ml/day) (oil-fed and cholesterol-fed groups, respectively). This model allowed the simultaneous examination of the effects of dietary cod-liver oil on vascular reactivity in hypercholesterolemia alone (right coronary artery) and in atherosclerosis (left coronary artery). After 10 weeks of feeding, the dietary treatment with cod-liver oil caused an increase in plasma levels of eicosapentaenoic acid and a decrease in the plasma levels of arachidonic acid, whereas the treatment had no significant effect on the increases in plasma lipid levels induced by the high-cholesterol feeding. Morphometric analysis...
Maximal heart rate and treadmill performance of healthy women in relation to age.
Authors: L TSheffield, J AMaloof, J ASawyer, DRoitman
Journal: Circulation (1978)

Maximal treadmill exercise heart rate, work capacity and electrocardiographic response were studied in 95 asymptomatic, predominantly sedentary women between the ages of 19 and 69 years. Average maximal heart rate (MHR) was found inversely related to age, such that MHR = 216 -0.88 (years of age) +/- 10 beats/min (X +/- 1 SD). Treadmill exercise endurance was 7.64 min +/- 1.99. The reduction of treadmill endurance with advancing age was not statistically significant. Asymptomatic ST-segment depression occurred in 6% of subjects. In 5% the ST segment sloped upward, and in 1% it was flat. Mean age of women with ST depression was 52 years, compared with 39 years mean age of all subjects. Premature beats during exercise were found in 20 of 95 subjects, and were not related to age. Graded exercise testing of women employing target heart rates should use heart rate tablets developed especially for women. These tables do not require correction for athletically trained for sedentary life-style.
Decreased collagen gene expression and absence of fibrosis in thyroid hormone-induced myocardial hypertrophy. Response of cardiac fibroblasts to thyroid hormone in vitro.
Authors: JYao, MEghbali
Journal: Circulation Research (1992)

The regulatory effects of thyroid hormone on biosynthesis of myocardial proteins that originate from cardiac myocytes are well established. Little is known, however, of regulatory effects of thyroid hormone on interstitial proteins. In this study we examined the effects of thyroid hormone on collagen gene expression in thyroid hormone-induced myocardial hypertrophy and the response of cardiac fibroblasts to thyroid hormone in culture. Adult male Sprague-Dawley rats were treated intraperitoneally with L-thyroxin (10 micrograms/100 g body wt) for 2 hours or 1, 2, 3, 6, 12, or 14 days. Northern blot analysis of RNA from total ventricular tissue showed that after 2 hours of treatment, the abundance of mRNA for pro alpha 2(I) collagen decreased by 53% (p less than 0.05) and reached the lowest level (60% decrease, p less than 0.02) at day 1, remained diminished at day 3, and then gradually returned toward normal levels. After transient transfection of chimeric DNA containing collagen type I promoter-chloramphen...
Drug company Servier is found guilty of manslaughter and aggravated deceit over Mediator diabetes drug
Authors: Barbara Casassus
Journal: BMJ (2021)

The French drug manufacturer Laboratoires Servier has been found guilty of manslaughter, involuntary injury, and aggravated deceit regarding a weight loss drug, Mediator.

The diabetes drug, which was withdrawn from the market in 2009 after 33 years, was widely prescribed as an appetite suppressant and is alleged to have caused hundreds of deaths in one of France’s worst ever health scandals.

On 29 March Servier was found guilty of manslaughter, involuntary injury, and aggravated deceit, but it was acquitted for fraud. The company was fined the legal maximum of €2.7m (£2.3m; $3.2m) for concealing the drug’s risks, and it was ordered to pay victims an estimated €160m in compensation.

Servier’s former deputy chief, Jean-Philippe Seta, was given a four year suspended jail sentence. Its founder, Jacques Servier, died in 2014. The French medicines agency ANSM was fined €303m for having “seriously failed in its …
132P Stage IV non-small cell lung cancer in the elderly: Real-world data
Authors: J.C. Monteiro, C. Amorim Costa, M. Rebordão Pires, A.C. Caetano, F.R. Salgueiro, I. Domingues, A.R. Meira Garcia, E. Jesus, N.A. Bonito, G. Sousa
Journal: Journal of Thoracic Oncology (2021)
Left ventricular pressure-volume and Frank-Starling relations in endurance athletes. Implications for orthostatic tolerance and exercise performance.
Authors: B DLevine, L DLane, J CBuckey, D BFriedman, C GBlomqvist
Journal: Circulation (1991)

BACKGROUNDEndurance athletes have a high incidence of orthostatic intolerance. We hypothesized that this is related to an abnormally large decrease in left ventricular end-diastolic volume (LVEDV) and stroke volume (SV) for any given decrease in filling pressure.METHODS AND RESULTSWe measured pulmonary capillary wedge (PCW) pressure (Swan-Ganz catheter), LVEDV (two-dimensional echocardiography), and cardiac output (C2H2 rebreathing) during lower body negative pressure (LBNP, -15 and -30 mm Hg) and rapid saline infusion (15 and 30 ml/kg) in seven athletes and six controls (VO2max, 68 +/- 7 and 41 +/- 4 ml/kg/min). Orthostatic tolerance was determined by progressive LBNP to presyncope. Athletes had steeper slopes of their SV/PCW pressure curves than nonathletes (5.5 +/- 2.7 versus 2.7 +/- 1.5 ml/mm Hg, p less than 0.05). The slope of the steep, linear portion of this curve correlated significantly with the duration of LBNP tolerance (r = 0.58, p = 0.04). The athletes also had reduced chamber stiffness (incr...
Hyperhomocysteinemia as a Risk Factor for Deep-Vein Thrombosis
Authors: M Cattaneo, I Martinelli, P M Mannucci
Journal: New England Journal of Medicine (1996)

Background.Previous studies have suggested that hyperhomocysteinemia may be a risk factor for venous thrombosis.Tb assess the risk of venous thrombosis associated with hyperhomocysteinemia, we studied plasma homocysteine levels in patients with a first episode of deep-vein thrombosis and in normal control subjects.Methode.We measured plasma homocysteine levels in 269 patients with a first, objectively diagnosed episode of deep-vein thrombosis and in 269 healthy controls matched to the patients according to age and sex.Hyperhomocysteinemia was defined äs a plasma homocysteine level above the 95th percentile in the control group (18.5 μηιοί per liter).Results.Of the 269 patients, 28 (10 percent) had plas-ma homocysteine levels above the 95th percentile for the controls, äs compared with 13 of the controls (matched odds ratio, 2.5; 95 percent confidence interval, 1.2 to 5.2).The association between elevated homocysteine levels and venous thrombosis was stronger among women than among men and increased with age.The exclusion of subjects with other established risk factors for thrombosis (e.g., a deficiency of protein C, protein S, or antithrombin; resistance to activated protein C; pregnancy or recent childbirth; or oral-contraceptive use) did not materially affect the risk estimates.Conclusions.High plasma homocysteine levels are a risk factor for deep-vein thrombosis in the general population.
Shall The Journal be Removed to Washington?
Authors: Geo. E. Fell
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hemodynamic effects of hydralazine in infants with a large ventricular septal defect.
Authors: R HBeekman, A PRocchini, ARosenthal
Journal: Circulation (1982)

To evaluate the effects of acute afterload reduction, hydralazine, 0.2 mg/kg, was administered at cardiac catheterization to seven infants who had a large ventricular septal defect (VSD). The infants were 2.5 - 11 months old (mean 5.1 months). Before and 5, 15, 25 and 35 minutes after hydralazine, aortic, pulmonary capillary wedge, pulmonary artery, right atrial and superior vena caval pressures and saturations, heart rate and oxygen consumption were measured. Hemodynamic effects were noted after 5 minutes but were most pronounced 35 minutes after hydralazine. Prehydralazine baseline data were therefore compared with values 35 minutes after hydralazine. Pulmonary flow did not changes, but systemic flow increased significantly (4.5 +/- 0.2 to 6.7 +/- 0.5 liters/min/m2 [mean +/- SEM], p less than 0.001). The pulmonary-to-systemic flow ratio decreased by 32% (3.4 +/- 0.4 to 2.3 +/- 0.2, p less than 0.001) and the absolute left-to-right shunt decreased by 24% (10.8 +/- 1.3 to 8.2 +/- 1.2 liters/min/m2, p less...
Usefulness of Oral Mucosal Transudate for HIV Antibody Testing-Reply
Authors: John H. Fitchen
Journal: JAMA (1997)

<h3>In Reply.</h3> —We agree with Dr Ryder's conclusion that "a positive EIA and indeterminate Western blot may be merely a false alarm." Oral mucosal transudate and blood HIV testing are subject to outcomes that are uncertain and require follow-up testing to arrive at a definitive result. When indeterminate HIV test results are interpreted by experts, inferences about true HIV status may be drawn from the magnitude of the EIA test signal and from the nature (viral vs nonviral) of individual Western blot bands. Thus, the tone of the message during counseling might differ depending on whether the test result is likely to be a false alarm or is distinctly worrisome. The predictive value of the "EIA component" of HIV testing may be of academic interest, but the clinically relevant factor is the full testing algorithm. Oral mucosal transudate testing never resulted in a false-positive outcome. Just as with blood, there are occasional
Effect of intravenous propranolol on coronary vasomotion at rest and during dynamic exercise in patients with coronary artery disease.
Authors: A SBortone, O MHess, AGaglione, TSuter, HNonogi, JGrimm, H PKrayenbuehl
Journal: Circulation (1990)

Coronary vasomotion was studied at rest and during bicycle exercise with biplane quantitative coronary arteriography in 28 patients with coronary artery disease. Patients were divided into two groups; the first 18 patients served as controls (group 1), and the next 10 patients were treated with propranolol 0.1 mg/kg, which was infused intravenously before exercise (group 2). Luminal area of a normal and a stenotic vessel segment was determined at rest, during supine bicycle exercise, and 5 minutes after sublingual administration of 1.6 mg nitroglycerin after exercise. In group 1, the normal vessel showed vasodilation (+16%, p less than 0.001) during exercise, whereas the stenotic vessel segment showed vasoconstriction (-31%, p less than 0.001). After sublingual administration of nitroglycerin, there was coronary vasodilation of both normal (+36%, p less than 0.001 vs. rest) and stenotic (+20%, p less than 0.001) vessel segments. Patients with angina pectoris during supine exercise (n = 10) had significant...
Prognostic significance of the number of induced ventricular complexes during assessment of therapy for ventricular tachyarrhythmias.
Authors: C DSwerdlow, R AWinkle, J WMason
Journal: Circulation (1983)

We analyzed 255 long-term trials of antiarrhythmic therapy, each of which had been evaluated at electrophysiologic study, to identify the maximum number of induced ventricular complexes consistent with the long-term efficacy of antiarrhythmic therapy. All patients had spontaneous and inducible sustained ventricular tachycardia or ventricular fibrillation. The incidence of therapeutic efficacy at 1 month and throughout follow-up was similar for trials in which zero, one, two, three, four, five, six to 10, and 11 to 15 complexes were induced, but significantly lower (p less than .001) for trials in which 16 or more complexes were induced. The cumulative incidence of efficacy at 1 year was 75 +/- 5% for 0 to 5 induced complexes, 72 +/- 11% for six to 10 complexes, 83 +/- 15% for 11 to 15 complexes, 42 +/- 10% for 16 complexes to 15 sec, and 48 +/- 6% for sustained ventricular tachycardia. At 1 year, the incidence of sudden death-free survival was higher for patients in trials that prevented initiation of s...
Predictive Factors for Fever After Endoscopic Submucosal Dissection in Colorectal Lesions
Authors: C Frias Gomes, J Revés, B Morão, C Nascimento, M Cravo, A Ferreira
Journal: Endoscopy (2021)

Aims Endoscopic submucosal dissection (ESD) is recommended for removal of colonic and rectal lesions with high suspicion of limited submucosal invasion. Fever is one of the most frequent side effects after this procedure. However, predictive factors for fever after-ESD, as well as the potential benefit of antibiotic prophylaxis remain unknown. Our goal was to identify risk factors for fever after-ESD.
Detection of myocardial infarction in vitro based on altered attenuation of ultrasound.
Authors: J WMimbs, D EYuhas, J GMiller, A NWeiss, B ESobel
Journal: Circulation Research (1977)

This study was designed to determine whether attenuation of ultrasound by myocardium is potentially useful in detecting and quantifying infarction. Accordingly, we analyzed 44 regions of myocardium from 11 dogs 4-10 weeks after coronary occlusion. Attenuation of ultrasound in each region was assessed by transmitting a broadband pulse through the tissue in vitro and carefully gating the appropriate pulse into a spectrum analyzer for Fourier analysis (frequency range, 2-9.5 MHZ). An ultrasonic index of attenuation was derived from the slope of the best-fit line relating attenuation and frequency obtained from the Fourier transform. Acquistion of ultrasonic data was improved with the use of a specially designed small diameter receiving transducer. Myocardial creatine kinase content was assayed in each region to provide an independent index of regional injury. Results obtained from ultrasonic and biochemical analyses correlated with a correlation coefficient between the two of 0.80 in 24 regions of myocardium...
Cryoblockade in limbic brain (amygdala) prevents or delays ventricular fibrillation after coronary artery occlusion in psychologically stressed pigs.
Authors: CCarpeggiani, CLandisman, M FMontaron, J ESkinner
Journal: Circulation Research (1992)

Neomammalian and paleomammalian (limbic) brain structures control different behaviors and the autonomic support specific to each. Both neural systems are involved in cardiovascular disorders. Our previous studies showed that bilateral cryoblockade of a neomammalian structure (the frontal lobes) reduces blood pressure elevations in experimental hypertension and prevents lethal arrhythmogenesis in experimental myocardial infarction. Other studies showed that bilateral lesions in a paleomammalian structure (amygdala) also reduce the blood pressure elevations. Thus, we hypothesized that cryoblockade of the amygdala would prevent lethal arrhythmogenesis. We found that cooling of cryoprobes implanted bilaterally in the amygdala prevented ventricular fibrillation in five of eight pigs during a 20-minute period of reversible myocardial ischemia, whereas cryoblockade in structures surrounding the amygdala (five pigs), unilateral cryoblockade in the amygdala (two pigs), or sham operations (three pigs) did not preve...
Neutrophil-mediated microvascular dysfunction in postischemic canine skeletal muscle. Role of granulocyte adherence.
Authors: D LCarden, J KSmith, R JKorthuis
Journal: Circulation Research (1990)

Recent studies implicate a role for granulocytes in the genesis of the microvascular and parenchymal cell dysfunction, which occurs upon reperfusion of ischemic tissues. Although the molecular mechanisms underlying this neutrophil-mediated injury are not completely understood, it is clear that an essential first step in granulocyte migration from the vascular lumen to the interstitial space is adherence to vascular endothelium. The purpose of this study was to determine whether prevention of neutrophil adherence with monoclonal antibody IB4 directed against the neutrophil CD11/CD18 glycoprotein adherence complex or neutrophil depletion with a specific polyclonal antineutrophil serum would attenuate the microvascular dysfunction seen in postischemic skeletal muscle. Changes in vascular permeability were assessed by measurement of the solvent drag reflection coefficient for total plasma proteins (sigma) in isolated canine gracilis muscle subjected to ischemia/reperfusion, ischemia/reperfusion plus antineutr...
Mechanism of hind limb vasoconstriction due to cyclosporin A in the dog.
Authors: FTronc, MCarrier, C LPelletier
Journal: Circulation Research (1992)

Cyclosporin A (CSA) causes an acute vasoconstriction of hind limb arterial vessels. To determine the mechanism of action of CSA on the peripheral arterial bed, studies were performed on the isolated femoral artery perfused at constant flow in 61 dogs. Changes in femoral perfusion pressure reflected variations in vascular resistance. Pure powder CSA was dissolved in autologous blood and injected at doses of 1, 5, 10, and 20 mg. Infusions of 1 and 5 mg CSA caused nonsignificant mean increases of 4 +/- 2 mm Hg (95% confidence interval [CI], 0-8; p > 0.05) and 10 +/- 4 mm Hg (95% CI, 0-21; p > 0.05) in femoral perfusion pressure, with CSA blood levels in the femoral vein averaging 40 +/- 16 and 126 +/- 50 nmol/l, respectively, at the end of the injections. Infusions of 10 and 20 mg CSA caused significant increases in femoral perfusion pressure averaging of 8 +/- 3 mm Hg (95% CI, 1-14; p < 0.05) and 20 +/- 4 mm Hg (95% CI, 11-29; p < 0.05) in femoral perfusion pressure. CSA blood levels at the end of injection...