tbuckley/cabot-search huggingface dataset:
Metastasis and Mortality in Men With Low- and Intermediate-Risk Prostate Cancer on Active Surveillance
Authors: P. Travis Courtney, Rishi Deka, Nikhil V. Kotha, Daniel R. Cherry, Mia A. Salans, Tyler J. Nelson, Abhishek Kumar, Elaine Luterstein, Anthony T. Yip, Vinit Nalawade, J. Kellogg Parsons, A. Karim Kader, Tyler F. Stewart, Brent S. Rose
Journal: Journal of the National Comprehensive Cancer Network (2022)

Background: Active surveillance (AS) is a safe treatment option for men with low-risk, localized prostate cancer. However, the safety of AS for patients with intermediate-risk prostate cancer remains unclear. Patients and Methods: We identified men with NCCN-classified low-risk and favorable and unfavorable intermediate-risk prostate cancer diagnosed between 2001 and 2015 and initially managed with AS in the Veterans Health Administration. We analyzed progression to definitive treatment, metastasis, prostate cancer–specific mortality (PCSM), and all-cause mortality using cumulative incidences and multivariable competing-risks regression. Results: The cohort included 9,733 men, of whom 1,007 (10.3%) had intermediate-risk disease (773 [76.8%] favorable, 234 [23.2%] unfavorable), followed for a median of 7.6 years. The 10-year cumulative incidence of metastasis was significantly higher for patients with favorable (9.6%; 95% CI, 7.1%–12.5%; P &lt;.001) and unfavorable intermediate-risk disease (19.2%; 95% CI, 13.4%–25.9%; P &lt;.001) than for those with low-risk disease (1.5%; 95% CI, 1.2%–1.9%). The 10-year cumulative incidence of PCSM was also significantly higher for patients with favorable (3.7%; 95% CI, 2.3%–5.7%; P &lt;.001) and unfavorable intermediate-risk disease (11.8%; 95% CI, 6.8%–18.4%; P &lt;.001) than for those with low-risk disease (1.1%; 95% CI, 0.8%–1.4%). In multivariable competing-risks regression, favorable and unfavorable intermediate-risk patients had significantly increased risks of metastasis and PCSM compared with low-risk patients (all P &lt;.001). Conclusions: Compared with low-risk patients, those with favorable and unfavorable intermediate-risk prostate cancer managed with AS are at increased risk of metastasis and PCSM. AS may be an appropriate option for carefully selected patients with favorable intermediate-risk prostate cancer, though identification of appropriate candidates and AS protocols should be tested in future prospective studies.
Diagnostic sensitivity of pleural fluid cytology in malignant pleural effusions: systematic review and meta-analysis
Authors: Shayan Kassirian, Stephanie N Hinton, Sean Cuninghame, Rushil Chaudhary, Alla Iansavitchene, Kayvan Amjadi, Inderdeep Dhaliwal, Cady Zeman-Pocrnich, Michael A Mitchell
Journal: Thorax (2022)

Background Pleural fluid cytology is an important diagnostic test used for the investigation of pleural effusions. There is considerable variability in the reported sensitivity for the diagnosis of malignant pleural effusions (MPE) in the literature. Objective The purpose of this review is to determine the diagnostic sensitivity of pleural fluid cytology for MPE, both overall and by tumour type, to better inform the decision-making process when investigating pleural effusions. Data sources A literature search of EMBASE and MEDLINE was performed by four reviewers. Articles satisfying inclusion criteria were evaluated for bias using the QUADAS-2 tool. Data extraction For quantitative analysis, we performed a metaanalysis using a binary random-effects model to determine pooled sensitivity. Subgroup analysis was performed based on primary cancer site and meta-regression by year of publication. Synthesis Thirty-six studies with 6057 patients with MPE were included in the meta-analysis. The overall diagnostic sensitivity of pleural fluid cytology for MPE was 58.2% (95% CI 52.5% to 63.9%; range 20.5%–86.0%). There was substantial heterogeneity present among studies (I 2 95.5%). For primary thoracic malignancies, sensitivity was highest in lung adenocarcinoma (83.6%; 95% CI 77.7% to 89.6%) and lowest in lung squamous cell carcinoma (24.2%; 95% CI 17.0% to 31.5%) and mesothelioma (28.9%; 95% CI 16.2% to 41.5%). For malignancies with extrathoracic origin, sensitivity was high for ovarian cancer (85.2%; 95% CI 74.2% to 96.1%) and modest for breast cancer (65.3%; 95% CI 49.8% to 80.8%). Conclusions Pleural fluid cytology has an overall sensitivity of 58.2% for the diagnosis of MPE. Clinicians should be aware of the high variability in diagnostic sensitivity by primary tumour type as well as the potential reasons for false-negative cytology results. PROSPERO registration number CRD42021231473.
Why Deaths of Despair Are Increasing in the US and Not Other Industrial Nations—Insights From Neuroscience and Anthropology
Authors: Peter Sterling, Michael L. Platt
Journal: JAMA Psychiatry (2022)

The US National Academy of Sciences reports rising mortality for US adults, most steeply for White adults with a secondary education or less. The rise is largely attributable to deaths of despair (suicide and poisoning by alcohol and drugs) with strong contributions from the cardiovascular effects of rising obesity. Although the report does acknowledge a crisis, it proposes mild measures to manage it, such as strengthening programs to support recovery, prevent relapse, increase resilience, and perform more research toward clinically useful definitions of despair. The US National Academy of Sciences report notes that mortality is decreasing in a control group of 16 wealthy nations (including countries in Western Europe, Canada, Australia, and Japan), but it does not ask what protects those nations from despair. It has been observed that human beings are constrained by evolutionary strategy (ie, huge brain, prolonged physical and emotional dependence, education beyond adolescence for professional skills, and extended adult learning) to require communal support at all stages of the life cycle. Without support, difficulties accumulate until there seems to be no way forward. The 16 wealthy nations provide communal assistance at every stage, thus facilitating diverse paths forward and protecting individuals and families from despair. The US could solve its health crisis by adopting the best practices of the 16-nation control group.
Acute aortic dissection: presentation, management and outcomes in 1996 — results from the International Registry for Aortic Dissection (IRAD)
Authors: P. Hagan, C.A. Nienaber, S. Das, A. Evangelista, R. Fatton, T. Suzuki, J.K. Oh, U. Sechtern, J.M.Y. Robles, H.-J. Deutsch, D. Gilon, D. Bhakta, D. Karavite, P. Russman, W.F. Armstrong, G.M. Deeb, E. Isselbacher, K.A. Eagle
Journal: Journal of the American College of Cardiology (1998)
Temporal progression of mediastinal lymphadenopathy in idiopathic pulmonary fibrosis
Authors: Tim J.M. Wallis, Eyjólfur Gudmundsson, Katarina Pontoppidan, Nesrin Mogulkoc, Recep Savaş, Ömer Selim Unat, Katharine Vedwan, Sobana Battison, Fiona J. Thompson, Christopher J. Brereton, Ben G. Marshall, Sophie V. Fletcher, Luca Richeldi, Joseph Jacob, Mark G. Jones
Journal: European Respiratory Journal (2022)

<b>In two separate cohorts of patients with idiopathic pulmonary fibrosis, mediastinal adenopathy was common and an increase in the size of lymphadenopathy independently predicts mortality</b>https://bit.ly/32vEMnX
A Score to Assess Mortality After Percutaneous Mitral Valve Repair
Authors: Sergio Raposeiras-Roubin, Marianna Adamo, Xavier Freixa, Dabit Arzamendi, Tomas Benito-González, Antonio Montefusco, Isaac Pascual, Luis Nombela-Franco, Josep Rodes-Cabau, Mony Shuvy, Antonio Portolés-Hernández, Cosmo Godino, Berenice Caneiro-Queija, Laura Lupi, Ander Regueiro, Chin Hion Li, Felipe Fernández-Vázquez, Simone Frea, Pablo Avanzas, Gabriela Tirado-Conte, Jean-Michel Paradis, Alona Peretz, Vanessa Moñivas, Jose A. Baz, Michele Galasso, Luca Branca, Laura Sanchís, Lluís Asmarats, Carmen Garrote-Coloma, Filippo Angelini, Victor León, Eduardo Pozo, Alberto Alperi, Ronen Beeri, Dario Cani, Manel Sabaté, Estefanía Fernández-Peregrina, Javier Gualis, Pier Paolo Bocchino, Salvatore Curello, Emad Abu-Assi, Andrés Íñiguez-Romo, Francesco Bedogni, Antonio Popolo Rubbio, Luca Testa, Carmelo Grasso, Rodrigo Estévez-Loureiro
Journal: Journal of the American College of Cardiology (2022)
About abortion--
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ambient Temperature Stable, Scalable COVID‐19 Polymer Particle Vaccines Induce Protective Immunity (Adv. Healthcare Mater. 3/2022)
Authors: Shuxiong Chen, Benjamin Evert, Adetayo Adeniyi, Mercè Salla‐Martret, Linda H.‐L. Lua, Victoria Ozberk, Manisha Pandey, Michael F. Good, Andreas Suhrbier, Peter Halfmann, Yoshihiro Kawaoka, Bernd H. A. Rehm
Journal: Advanced Healthcare Materials (2022)

Sars-CoV-2 Vaccines In article number 2102089 by Bernd H. A. Rehm and co-workers, an ambient temperature-stable, scalable COVID-19 polymer particle vaccines are developed by engineering endotoxinfree bacterial cell factories to self-assemble biopolymer particles coated with immunogenic SARS-CoV-2 antigens. Polymer particle vaccines induce protective immunity in a hamster SARS-CoV-2 infection model reducing virus titers up to viral clearance in lungs post infection.
Long-Term Survival after Kidney Transplantation
Authors: Sundaram Hariharan, Ajay K. Israni, Gabriel Danovitch
Journal: New England Journal of Medicine (2021)

This review discusses demographics, survival, and risks in kidney transplantation since the mid-1990s. It addresses postoperative events that impede long-term survival, as well as factors relevant to racial or ethnic minority recipients and health care coverage for immunosuppressive agents.
SARS-CoV-2 surveillance in households with and without asthmatic/allergic children: The Human Epidemiology and Response to SARS-CoV-2 study (HEROS)
Authors: Max Seibold, Camille Moore, Jamie Everman, Blake Williams, James Nolin, Ana Fairbanks-Mahnke, Elizabeth Plender, Bhavika Patel, Samuel Arbes, Leonard Bacharier, Casper Bendixsen, Agustin Calatroni, Carlos Camargo, William Dupont, Glenn Furuta, Tebeb Gebretsadik, Rebecca Gruchalla, Ruchi Gupta, Gurjit Khurana Hershey, Liza Murrison, Daniel Jackson, Christine Johnson, Meyer Kattan, Andrew Liu, Stephanie Lussier, George O’Connor, Katherine River-Spoljaric, Wanda Phipatanakul, Marc Rothenberg, Christine Seroogy, Stephen Teach, Edward Zoratti, Alkis Togias, Patricia Fulkerson, Tina Hartert
Journal: Journal of Allergy and Clinical Immunology (2022)
PhenoPad: Building AI enabled note-taking interfaces for patient encounters
Authors: Jixuan Wang, Jingbo Yang, Haochi Zhang, Helen Lu, Marta Skreta, Mia Husić, Aryan Arbabi, Nicole Sultanum, Michael Brudno
Journal: npj Digital Medicine (2022)

Current clinical note-taking approaches cannot capture the entirety of information available from patient encounters and detract from patient-clinician interactions. By surveying healthcare providers' current note-taking practices and attitudes toward new clinical technologies, we developed a patient-centered paradigm for clinical note-taking that makes use of hybrid tablet/keyboard devices and artificial intelligence (AI) technologies. PhenoPad is an intelligent clinical note-taking interface that captures free-form notes and standard phenotypic information via a variety of modalities, including speech and natural language processing techniques, handwriting recognition, and more. The output is unobtrusively presented on mobile devices to clinicians for real-time validation and can be automatically transformed into digital formats that would be compatible with integration into electronic health record systems. Semi-structured interviews and trials in clinical settings rendered positive feedback from both clinicians and patients, demonstrating that AI-enabled clinical note-taking under our design improves ease and breadth of information captured during clinical visits without compromising patient-clinician interactions. We open source a proof-of-concept implementation that can lay the foundation for broader clinical use cases.
Observations on the Chromosomes of Chinese Hamster Cells in Tissue Culture<xref ref-type="fn" rid="FN1">2</xref>
Authors: Denys K. Ford, George Yerganian
Journal: JNCI Journal of the National Cancer Institute (1958)

Serial studies have been made on the chromosomal complement of 4 cell lines derived from the lungs of healthy normal Chinese hamsters and maintained in tissue culture for 3 to 14 months. In the early days of in vitro life, the cell lines were characterized by a diploid chromosomal complement, but metaphases with an approximately tetraploid number soon appeared. When diploid cells became a minority, there were usually significant numbers of approximately triploid and more-than-tetraploid metaphases. Detailed chromosomal analysis revealed abnormalities in cells which, to superficial examination, would have been classed as diploid. Particular patterns of extra chromosomes, absent chromosomes, functioning half chromosomes, and aberrant chromosomes characterized 2 of the cell lines and also a methylcholanthrene-treated subline of 1 of them.
Leisure Corner
Authors: Marjorie C. Meehan
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Autonomous sensing of the insulin peptide by an olfactory G protein-coupled receptor modulates glucose metabolism
Authors: Jie Cheng, Zhao Yang, Xiao-Yan Ge, Ming-Xin Gao, Ran Meng, Xin Xu, Yu-Qi Zhang, Rui-Zhe Li, Jing-Yu Lin, Zhao-Mei Tian, Jin Wang, Shang-Lei Ning, Yun-Fei Xu, Fan Yang, Jing-Kai Gu, Jin-Peng Sun, Xiao Yu
Journal: Cell Metabolism (2022)
Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment
Authors: Chiara Falcomatà, Stefanie Bärthel, Sebastian A. Widholz, Christian Schneeweis, Juan José Montero, Albulena Toska, Jonas Mir, Thorsten Kaltenbacher, Jeannine Heetmeyer, Jonathan J. Swietlik, Jing-Yuan Cheng, Bianca Teodorescu, Oliver Reichert, Constantin Schmitt, Kathrin Grabichler, Andrea Coluccio, Fabio Boniolo, Christian Veltkamp, Magdalena Zukowska, Angelica Arenas Vargas, Woo Hyun Paik, Moritz Jesinghaus, Katja Steiger, Roman Maresch, Rupert Öllinger, Tim Ammon, Olga Baranov, Maria S. Robles, Julia Rechenberger, Bernhard Kuster, Felix Meissner, Maximilian Reichert, Michael Flossdorf, Roland Rad, Marc Schmidt-Supprian, Günter Schneider, Dieter Saur
Journal: Nature Cancer (2022)
Transient Receptor Potential Cation Channel Subfamily V Member 1 (TRPV1) Plays a Major Role in Low Temperature-Mediated Skin Barrier Dysfunction: Potential Implications for Atopic Dermatitis and Food Allergy
Authors: Byung Kim, Jessica Hui, Cliff Hall, Taras Lyubchenko, Elena Goleva, Donald Leung
Journal: Journal of Allergy and Clinical Immunology (2022)
THE LYMPHOCYTES IN TUBERCULOUS INFECTIONS.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical Education, Registration and Hospital Service
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heberden Society
Journal: Annals of the Rheumatic Diseases (1961)

HEBERDEN SOCIETYCambridge, Bath, and London, being only a few of the places in Great Britain where research was going on.One of the most important inquiries was being carried on at the University of Birmingham under Professor J. R. Squire.A sum of £200,000 had been raised among local industrialists to cover the cost of a special wing of the Queen Elizabeth Hospital, the building of which should be completed during 1962. COMMONWEALTHSister organizations in Canada, Australia
Effect of a serogroup A meningococcal conjugate vaccine (PsA–TT) on serogroup A meningococcal meningitis and carriage in Chad: a community study
Authors: DM Daugla, JP Gami, K Gamougam, N Naibei, L Mbainadji, M Narbé, J Toralta, B Kodbesse, C Ngadoua, ME Coldiron, F Fermon, A-L Page, MH Djingarey, S Hugonnet, OB Harrison, LS Rebbetts, Y Tekletsion, ER Watkins, D Hill, DA Caugant, D Chandramohan, M Hassan-King, O Manigart, M Nascimento, A Woukeu, C Trotter, JM Stuart, MCJ Maiden, BM Greenwood
Journal: The Lancet (2013)

A serogroup A meningococcal polysaccharide-tetanus toxoid conjugate vaccine (PsA-TT, MenAfriVac) was licensed in India in 2009, and pre-qualified by WHO in 2010, on the basis of its safety and immunogenicity. This vaccine is now being deployed across the African meningitis belt. We studied the effect of PsA-TT on meningococcal meningitis and carriage in Chad during a serogroup A meningococcal meningitis epidemic.
Molecular Pathways: Targeting <i>NRG1</i> Fusions in Lung Cancer
Authors: Lynnette Fernandez-Cuesta, Roman K. Thomas
Journal: Clinical Cancer Research (2014)

Abstract The four members of the ERBB (HER) family of transmembrane receptor tyrosine kinases are frequently activated in cancer by several mechanisms, such as mutation, amplification, or autocrine ligand–receptor stimulation. We recently identified gene fusions involving the ERBB ligand gene, NRG1, which represent a novel mechanism for ERBB pathway deregulation. These fusions lead to expression and presentation of the EGF-like domain of NRG1 on the cell surface, which binds to ERBB3 in an autocrine and juxtacrine manner, thus inducing the formation of ERBB2–ERBB3 heterodimers, and subsequent activation of the PI3K–AKT and MAPK signaling pathways. These fusion genes were exclusively detected in lung adenocarcinomas of never smokers of the invasive mucinous subtype, which usually presents as a multifocal and unresectable disease, for which no effective treatment exists. Considering the large amount of drugs that target ERBB2 (HER2) and ERBB3 (HER3), and which are currently in different stages of clinical development, detecting and targeting NRG1 fusions in invasive mucinous lung adenocarcinomas may represent a therapeutic opportunity for this aggressive disease. Clin Cancer Res; 21(9); 1989–94. ©2014 AACR.
Contents
Authors: Manh Quoc, Sathanur Nguyen, Ji-Hua Srinivasan, Wei Xu, Gerald Chen, Verónica Miksztowicz, Maria Muzzio, Monique Royer, Mariela Prada, Regina Wikinski, Laura Schreier, Gabriela Berg, Rizwana Kousar, Cate Burns, Paul Lewandowski, Anne Kunnari, Merja Santaniemi, Maarit Jokela, Anna Karjalainen, Jorma Heikkinen, Olavi Ukkola, Y Kesäniemi, Xiaoli Chen, Jay Matthews, Lubing Zhou, Patricia Pelton, Yin Liang, Jun Xu, Maria Yang, Ellen Cryan, Philip Rybczynski, Keith Demarest
Journal: Metabolism (2008)