tbuckley/cabot-search huggingface dataset:
First Report of Reversible Macrocytic Anemia with Dysplastic Features Associated with Palbociclib Use in Patients with Metastatic Breast Cancer
Authors: Tamanna Haque, Jesus Anampa, Irina Murakhovskaya, Yanhua Wang, Kimo Bachiashvili, Cristian Papazoglu, Kith Pradhan, Ulrich G. Steidl, Amit Verma
Journal: Blood (2017)
Internal Medicine Certification: Scores Slip; Spirochete Survives-Reply
Authors: Bruce B. Dan
Journal: JAMA (1990)

<h3>In Reply.—</h3> Dr Cary should consider himself extraordinarily fortunate that he managed to pass the certifying examination given by the American Board of Internal Medicine, because if he tried his outlandish theory on cognitive functioning on our colleagues in neurology, he surely would have been sent back for another year of residency. Contrary to his assertion that internal medicine residents can only acquire new information about diseases at the expense of others, the brain does not have a fixed capacity for learning. We would live in a bizarre world indeed if for each new fact learned an older memory had to be cast out. You do not forget how to balance your checkbook as a result of learning a new recipe for chili, and your ability to diagnose and care for a patient with rheumatoid arthritis is not compromised by being able to recognize and treat Lyme disease. The trends in the
Update in Endocrinology
Authors: Randall W. Whitcomb
Journal: Annals of Internal Medicine (1998)

Letters15 May 1998Update in EndocrinologyRandall W. Whitcomb, MDRandall W. Whitcomb, MDParke-Davis Pharmaceutical Research; Ann Arbor, MI 48105Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-10-199805150-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:This letter is written to clarify several statements in the article “Update in Endocrinology” [1]. First, the article stated that neutropenia may occur in up to 20% of patients receiving troglitazone. It seems that this statement is based on data from Kumar and coworkers [2]. The actual report referenced states “… there was a decrease in the neutrophil count (to less than 0.9 times the lower limit of normal) in 9-20% of patients receiving troglitazone, with the highest incidences at the highest doses, although similar decreases were seen in 9% of patients on placebo.” The data from ...References1. Schlechte JA, Kreisberg R. Update in endocrinology. Ann Intern Med. 1998; 128:378-85. Google Scholar2. Kumar S, Boulton AJ, Beck-Nielsen H, Berthezene F, Muggeo M, Persson B, et al. Troglitazone, an insulin action enhancer, improves metabolic control in NIDDM patients. Troglitazone Study Group. Diabetologia. 1996; 39:701-9. Google Scholar3. Prescribing Information for Rezulin (Troglitazone). Morris Plains, NJ: Parke-Davis Pharmaceuticals; December 1997. Google Scholar4. FDA Talk Paper. Rezulin Labeling Changes. 3 November 1997. Google Scholar Author, Article, and Disclosure InformationAuthors: Randall W. Whitcomb, MDAffiliations: Parke-Davis Pharmaceutical Research; Ann Arbor, MI 48105 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 1998Volume 128, Issue 10Page: 871KeywordsEndocrinologyFood and Drug AdministrationHemoglobinInsulinLiverLiver transplantationNeutropeniaNeutrophilsPlasma volumeType 2 diabetes ePublished: 15 August 2000 Issue Published: 15 May 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Development of a shared decision-making tool in vitiligo: an international study
Authors: J. Shourick, M. Ahmed, J. Seneschal, T. Passeron, N. Andreux, A. Qureshi, E.Y. Chow, P.A. Natella, J. Harris, V.-T. Tran, K. Ezzedine
Journal: British Journal of Dermatology (2021)

Summary Background Shared decision-making tools (SDMt) are visual tools developed to promote joint medical decisions between physicians and patients. There is a paucity of such tools in dermatology. Objectives To develop and validate a SDMt for use in specialized consultation for vitiligo. Methods A prospective cross-sectional study was carried out from March 2019 to March 2020. We first conducted a qualitative study of topics discussed by patients and clinicians during therapeutic decision-making in the setting of a specialized consultation for vitiligo using an anchored-theory method, which allowed conceptualization of the SDMt. The usefulness of the SDMt was evaluated by a working group of multidisciplinary health workers and patients with vitiligo. Consensus on the final tool was obtained through an e-Delphi method. Results We recruited 30 patients with vitiligo for the qualitative study, which identified 91 topics related to therapeutic decision-making. Hierarchical clustering analysis confirmed the distribution of these topics in two subgroups (general treatment goals and priorities, and topics specific to each treatment). The consensus of a multidisciplinary group was used to develop the SDMt. The tool was comprised of eight A5 cards, which addressed face repigmentation; body repigmentation (limited area); body repigmentation (extended area); partial or complete depigmentation; coping with the disease; stabilization of disease; maintaining repigmentation; and disease information. Cognitive interviews confirmed the satisfaction, readability and usefulness of the SDMt. The SDMt was then translated and culturally validated in English. Conclusions We developed a tool for shared decision-making in nonsegmental vitiligo, which we translated and cross-culturally validated in a US patient population with vitiligo to ensure its generalizability.
Ascending aortic impedance patterns in the kangaroo: their explanation and relation to pressure waveforms.
Authors: W WNichols, A PAvolio, M FO'Rourke
Journal: Circulation Research (1986)

This study seeks to explain mechanisms responsible for the peculiar ascending aortic pressure waveform and impedance spectral pattern in kangaroos. Pulsatile pressure and blood flow velocity were measured and input impedance calculated in the ascending aorta, descending thoracic aorta, and brachiocephalic artery of 15 rock kangaroos. Pressure and velocity waveforms and impedance spectral patterns were interpreted with the aid of an asymmetric uniform T-tube model of the systemic arterial tree. The ascending aortic pressure waveform displayed a very large secondary wave that began in late systole or early diastole and continued throughout most of diastole. The peak of this secondary wave (which almost always occurred in diastole) was often greater than peak systolic pressure and results from apparently intense wave reflections from peripheral vascular beds. This contention is supported by the configuration of the impedance spectral pattern that is explained on the basis of a single (or dominant) functional...
Lesion of the area postrema region attenuates hypertension in spontaneously hypertensive rats.
Authors: M LMangiapane, K MSkoog, PRittenhouse, M LBlair, C DSladek
Journal: Circulation Research (1989)

To determine whether the area postrema contributes to the development of hypertension in spontaneously hypertensive rats (SHR), sham or electrolytic lesions of the area postrema (AP) were made in 4-week-old SHR and Wistar-Kyoto (WKY) controls. From weeks 5 through 16, systolic pressure was measured via tail plethysmography. While blood pressure rose markedly in sham-operated SHR, increases in pressure were small in AP-ablated SHR and similar to those seen in all WKY. Subsequent direct measurements of mean arterial pressure in the same rats showed a significant correlation (r = 0.87, p less than 0.01) with the pressure data acquired via weekly tail-cuff measurement, thereby confirming that hypertension in AP-ablated SHR had indeed been attenuated. Analysis of several hundred computer-acquired measurements of mean arterial pressure from each rat showed that AP ablation shifted the distribution of mean arterial pressure to a lower range in SHR but not WKY. Ablation of the AP also decreased resting heart rate...
Shall The Journal be Removed to Washington?
Authors: A. A. Young
Journal: JAMA (1891)

THE ACTION OF THE WAYNE CO., N. Y., MEDICAL SOCIETY.  To the Editor:  —I send you a copy of the resolution passed, unanimously, by the Wayne Co. Medical Society at its quarterly meeting held today.  D.Colvin, M.D.  Palmyra, Wayne Co., N. Y., April 14, 1891.  Resolved, That we deplore the agitation now going on relative to the removal of the office of publication ofThe Journal of the American Medical Association, and we earnestly protest against any and every attempt to change the present locality of its publication.
Preferential distribution of inhibitory cardiac receptors with vagal afferents to the inferoposterior wall of the left ventricle activated during coronary occlusion in the dog.
Authors: M DThames, H SKlopfenstein, F MAbboud, A LMark, J LWalker
Journal: Circulation Research (1978)

The purpose of this study was to determine the relative magnitudes of the reflex effects mediated by cardiac receptors during anterior as opposed to inferoposterior ischemia of the left ventricle of the dog. Cessation of perfusion (coronary occlusion) of the circumflex coronary artery (Cx) in 29 chloralose-anesthetized dogs with common carotids ligated (group I) resulted in significant bradycardia and hypotension, but in no significant change in perfusion pressure in the gracilis muscle perfused at constant flow. Occlusion of the left anterior descending coronary artery (LAD) produced less hypotension, no change in heart rate, and vasoconstriction in the gracilis. After vagotomy and aortic nerve section, no significant change in heart rate or gracilis perfusion pressure was observed during lad or Cx occlusion, and the blood pressure responses to LAD and Cx occlusion were not different. In nine dogs with sinoaortic denervation (group II), brief Cx occlusion resulted in bradycardia, hypotension, and vasod...
Preservation of high-energy phosphates by verapamil in reperfused myocardium.
Authors: RLange, JIngwall, S LHale, K JAlker, EBraunwald, R AKloner
Journal: Circulation (1984)

To determine whether verapamil prevents depletion of adenine nucleotides during and after severe myocardial ischemia, dogs were subjected to 15 min occlusions of the left anterior descending coronary artery followed by 240 min of reperfusion. One hour before occlusion, dogs were randomly assigned to a treatment group (n = 10) to which an infusion of intravenous verapamil was given until the onset of reperfusion or to an untreated saline group (n = 9). Verapamil reduced mean aortic pressure and heart rate. After 15 min of ischemia, endocardial adenosine triphosphate (ATP) level, determined by needle biopsy, decreased in the untreated group from 34.7 +/- 2.0 to 24.4 +/- 2.7 nmol X mg protein-1 (p less than .005 vs preocclusion) and in the verapamil group from 32.8 +/- 1.5 to 30.3 +/- 1.5 nmol X mg protein-1 (NS vs preocclusion). Dogs receiving verapamil had significantly higher ATP levels than untreated animals after 90 and 240 min of reperfusion. In untreated animals the sum of inosine and hypoxanthine lev...
Rectal Band Ligation as an Alternative Treatment for Chronic Radiation Proctitis
Authors: L Lamonaca, F Auriemma, D Paduano, M Bianchetti, R Maselli, PA Galtieri, A Repici, B Mangiavillano
Journal: Endoscopy (2021)

Aims Chronic radiation proctitis (CRP) occurs in 10-15 % of patients undergoing pelvic radiation therapy and frequently manifests with rectal bleeding, requiring blood transfusion. Endoscopic management of more severe and refractory cases of rectal hemorrhage is possible and argon plasma coagulation (APC) is currently recommended as the first-choice treatment although there is evidence of limited efficacy in cases of extensive rectal involvement. Rectal band ligation (RBL) has been shown to be a feasible alternative to APC. Our aim is to describe safety and efficacy of RBL in chronic hemorrhagic radiation proctitis.
Thallium-201 uptake in variant angina: probable demonstration of myocardial reactive hyperemia in man.
Authors: M WKronenberg, R MRobertson, M LBorn, R ASteckley, DRobertson, G CFriesinger
Journal: Circulation (1982)

Myocardial thallium scintigraphy was performed in four subjects with variant angina and in one subject with isolated, fixed coronary obstruction. Three subjects with variant angina had short episodes of ischemic ST-segment elevation that lasted 20--100 seconds. Thallium scintigrams demonstrated excess uptake in regions judged to be ischemic by angiographic and electrocardiographic criteria. Two subjects, one with variant angina and the other with a fixed coronary lesion, had prolonged episodes of ischemia that lasted 390--900 seconds. Both had reduced thallium uptake in the ischemic regions. We conclude that myocardial reactive hyperemia is the cause of excess thallium uptake in patients with variant angina who have short episodes of myocardial ischemia.
Neodymium:YAG laser photocoagulation: a successful new map-guided technique for the intraoperative ablation of ventricular tachycardia.
Authors: R HSvenson, J JGallagher, J GSelle, S HZimmern, J MFedor, FRobicsek
Journal: Circulation (1987)

Neodymium:YAG laser photocoagulation was used in the intraoperative treatment of drug-resistant ventricular tachycardia (VT) in 17 consecutive patients. The cause of VT was previous myocardial infarction in 15, sarcoid in one, and idiopathic in one patient. Electrophysiologic studies were performed preoperatively, before hospital discharge, and 8 to 12 weeks and 1 year after surgery. At surgery, laser photocoagulation was performed on the normothermic heart during VT. Surgical mortality was 11.7%. There was one late nonarrhythmic death 35 days postoperatively. There were 55 VT morphologies. Laser successfully abated 52 of 55. Associated use of cryoablation was required in two of 55. One VT in the patient with sarcoidosis was not successfully ablated but was controlled by procainamide. In the long-term survivors with VT due to myocardial infarction the surgical cure rate was 100%, i.e., no spontaneous or inducible VT. Follow-up ranges from 6 to 18 months (mean 11.8 +/- 4.3). Nd:YAG laser photocoagulation i...
Fluoridation of drinking water.
Authors: L Vaughan
Journal: BMJ (1993)

drop out (36% with SSRI and 39% with tricyclic antidepressants; p=0-34).Both studies quoted by Hale as showing an advantage of SSRIs over tricyclic antidepressants in long term compliance were placebo controlled, not including tricyclic antidepressants.In summary, there seems little evidence to support the routine first line use of SSRIs.The debate has now shifted to the issues of suicide by overdose and costs.This cannot be resolved by reference to the trial data and will be the subject of a further paper.SmithKline Beecham and Lilly Industries Ltd refer to data from unpublished studies, which therefore cannot be commented on.The burden of proof must lie with those who advocate the use of expensive new drugs on the basis of improved tolerability.
Preferential venoconstriction by cyclooxygenase inhibition in vivo without attenuation of nitroglycerin venodilation.
Authors: TMünzel, D JStewart, JHoltz, EBassenge
Journal: Circulation (1988)

Because prostacyclin is a rather potent venodilator in vivo, we analyzed the effect of cyclooxygenase inhibition on venous tone in 14 anesthetized dogs during ganglionic and beta-adrenergic blockade and atraumatic conditions. Effective vascular stiffness (a reciprocal of effective vascular compliance) as a variable of integrated venous tone was 0.30 +/- 0.01 mm Hg.kg/ml (n = 35) and was augmented up to twofold by diclofenac (1, 3, and 10 mg/kg i.v.), ibuprofen (6 and 60 mg/kg), or indomethacin (5 mg/kg) parallel to augmentations in central venous pressure, while the rise in arterial pressure was less than half of the increase induced by equivenoconstrictor dosages of norepinephrine. After preconstriction by indomethacin or diclofenac, nitroglycerin (1.5 micrograms/kg/min) lowered effective vascular stiffness (by 24 +/- 2% or 23 +/- 5%, respectively), similarly as during preconstriction by norepinephrine (by 24 +/- 4%). Long-term cyclooxygenase inhibition (diclofenac 2 x 1 mg/kg/day for 4 days) did not mod...
The Cytochromes P450 and Mechanisms of Chemical Carcinogenesis
Authors: Dennis V. Parke
Journal: Environmental Health Perspectives (1994)

This article reviews mechanisms of chemical carcinogenesis, from metabolic activation and generation of reactive oxygen species by cytochromes P4511 and P4502E to DNA damage, activation of protein kinase C and ocogenes, hyperplasia, and proteoglycan changes in the cell glycocalyx and lysosomal enzymes which mediate invasion and metastasis.
Exercise intolerance in patients with chronic heart failure: role of impaired nutritive flow to skeletal muscle.
Authors: J RWilson, J LMartin, DSchwartz, NFerraro
Journal: Circulation (1984)

The maximal exercise capacity of patients with chronic heart failure is frequently reduced. To investigate whether this exercise intolerance is caused by inadequate nutritive flow to skeletal muscle, we compared cardiac outputs, leg blood flow, and leg metabolism during maximal bicycle exercise in seven patients with normal maximal oxygen uptake (VO2) (greater than 20 ml/min/kg; group A), eight patients with heart failure and moderately reduced maximal VO2 (15 to 18 ml/min/kg; group B), and eight patients with heart failure and markedly reduced maximal VO2 (less than 14 ml/min/kg; group C). As the severity of exercise intolerance increased from group A to group C there was a progressive decline in cardiac output and leg blood flow at any given workload accompanied by a progressive decline in maximal cardiac output (liters/min) (A, 12.4 +/- 1.0; B, 8.7 +/- 0.9; C, 5.5 +/- 0.7), maximal leg flow (liters/min) (A, 4.0 +/- 0.3; B, 2.6 +/- 0.4; C, 1.4 +/- 0.2), and maximal leg VO2 (ml/min) (A, 564 +/- 49; B, 40...
Angiographic and hemodynamic determinants of myocardial ischemia during adenosine thallium-201 scintigraphy in coronary artery disease.
Authors: SNishimura, K TKimball, J JMahmarian, M SVerani
Journal: Circulation (1993)

BACKGROUNDMyocardial ischemia attributed to coronary steal may occur in some patients receiving pharmacological coronary vasodilation. ECG ST-segment depression is a marker of myocardial ischemia in these patients, but the factors determining the presence or absence of ischemia are not well known.METHODS AND RESULTSTo examine the angiographic, hemodynamic, and scintigraphic determinants of adenosine-induced ischemic ST-segment depression in patients with coronary artery disease, we studied 65 consecutive patients (45 men and 20 women; mean age, 65 +/- 12 years) who showed reversible perfusion defects during adenosine (140 micrograms.kg-1.min-1 for 6 minutes) 201Tl single-photon emission computed tomography. Patients with prior myocardial infarction were excluded. Ischemic ST depression occurred in one third of the whole cohort (22 of 65 patients). The presence of coronary collateral vessels (p = 0.001), systolic blood pressure at baseline (p = 0.006), and adenosine-induced anginal chest pain (p = 0.011) w...
Comparison of surgical resection versus transarterial chemoembolization with additional radiation therapy in patients with hepatocellular carcinoma with portal vein invasion
Authors: Jin Wook Chung
Journal: Clinical and Molecular Hepatology (2018)

See the Original "Comparison of surgical resection versus transarterial chemoembolization with additional radiation therapy in patients with hepatocellular carcinoma with portal vein invasion" on page 144.
Hemodynamic effects of exogenous and endogenous vasopressin at low plasma concentrations in conscious dogs.
Authors: J PMontani, J FLiard, JSchoun, JMöhring
Journal: Circulation Research (1980)

The possibility that vasopressin plays a role in cardiovascular control arouses increasing interest. We studied in unanesthetized dogs the hemodynamic consequences of 1-hour vasopressin infusions that modified plasma concentrations over a range similar to that found in physiological situations. We also examined the cardiovascular events following the stimulation of endogenous vasopressin release by an increase in plasma osmolality. In dogs with baroreceptor reflexes intact, vasopressin infusions which increased plasma vasopressin concentration by 2-20 fmol/ml did not affect mean arterial pressure. However, they significantly decreased cardiac ouput (measured by an electromagnetic flowmeter) and increased total peripheral resistance. After baroreceptor denervation, vasopressin infusion rates as low as 40 fmol/kg per min (0.017 microU/kg per min) led to an increase in mean arterial pressure. Cardiac output was unaffected until much higher infusion rates were used. Changes in total peripheral resistance were...
99mTc-sestamibi uptake and retention during myocardial ischemia and reperfusion.
Authors: G ABeller, D KGlover, N CEdwards, MRuiz, J PSimanis, D DWatson
Journal: Circulation (1993)

BACKGROUND99mTc-methoxyisobutyl isonitrile (Sestamibi) is a new perfusion agent that has shown promise for the noninvasive detection of myocardial salvage after coronary reperfusion in acute myocardial infarction. The objective of this study was to further validate that myocardial uptake and retention of Sestamibi after reperfusion in a canine myocardial infarction model are markers of tissue viability. The hypotheses tested were that if Sestamibi is given early after reperfusion and myocardial uptake is quantitated soon afterward, the degree of ultimate myocardial salvage will be overestimated, and that there will be continued loss of myocardial Sestamibi from ischemic tissue during 3 hours of reperfusion due to accelerated release of Sestamibi from cells already irreversibly injured during the phase of coronary occlusion, reperfusion injury to myocytes still viable early after reflow, or a combination of both mechanisms.METHODS AND RESULTSIn protocol 1, 8.0 mCi Sestamibi was injected intravenously in an...
The surgical management of discrete and diffuse supravalvar aortic stenosis.
Authors: J FKeane, K EFellows, C GLaFarge, A SNadas, W FBernhard
Journal: Circulation (1976)

Between 1956 and 1976, 18 patients underwent surgery for supravar aortic stenosis at the The Children's Hospital Medical Center, Boston. Discrete obstruction, present in 11, was treated by insertion of a prosthetic gusset placed across the area of narrowing and extending into the noncoronary sinus of Valsalva. There was one operative death. Residual gradients (measured in five patients) ranged from 4-55 mm Hg, one of which was supravalvar in location. Significant aortic regurgitation was not common preoperatively. The diffuse form of supravalvar obstruction, a more difficult surgical problem, was present in seven patients. There were three operative deaths. Complete relief of the pressure gradient was achieved only in one instance by insertion of a left ventricular-aortic bypass shunt diverting the majority of the cardiac output into the descending thoracic aorta. This patient is now asymptomatic 20 months following operation. On the basis of this experience, it is suggested that patients with the diffuse...