tbuckley/cabot-search huggingface dataset:
Author Correction: The next phase of SARS-CoV-2 surveillance: real-time molecular epidemiology
Authors: Bas B. Oude Munnink, Nathalie Worp, David F. Nieuwenhuijse, Reina S. Sikkema, Bart Haagmans, Ron A. M. Fouchier, Marion Koopmans
Journal: Nature Medicine (2021)
Kynurenine derivative 3-HAA is an agonist ligand for transcription factor YY1
Authors: Zhaopeng Shi, Guifang Gan, Xiang Xu, Jieying Zhang, Yuan Yuan, Bo Bi, Xianfu Gao, Pengfei Xu, Wenbin Zeng, Jixi Li, Youqiong Ye, Aiwu Zhou, Naixia Zhang, Wen Liu, Shuhai Lin, Jun Mi
Journal: Journal of Hematology & Oncology (2021)

Abstract The 3-hydroxyanthranilic acid (3-HAA), a derivative of kynurenine, was reported to suppress tumor growth. However, the function of 3-HAA largely remains unclear. Here, we report that 3-hydroxyanthranilic acid (3-HAA) is lower in tumor cells, while adding exogenous 3-HAA induces apoptosis in hepatocellular carcinoma by binding YY1. This 3-HAA binding of YY1 leads to phosphorylation of YY1 at the Thr 398 by PKCζ, concomitantly enhances YY1 chromatin binding activity to increase expression of target genes. These findings demonstrate that 3-HAA is a ligand of YY1, suggesting it is a promising therapeutic candidate for HCC.
1131P Intraoperative assessment of negative resection margins in breast-conserving surgery using optical coherence elastography
Authors: E.V. Gubarkova, A.A. Plekhanov, M.A. Sirotkina, D.A. Vorontsov, A.A. Sovetsky, A.L. Matveyev, S.S. Kuznetsov, L.A. Matveev, E.V. Zagaynova, G.V. Gelikonov, A.Y. Vorontsov, V.Y. Zaitsev, N.D. Gladkova
Journal: Annals of Oncology (2021)
417P Liquid biopsy driven anti-EGFR rechallenge in metastatic colorectal cancer
Authors: M. Puzzoni, R. Giampieri, S. Mariani, P. Ziranu, V. Pusceddu, C. Donisi, M. Persano, G. Pinna, E. Cimbro, A. Parrino, A. Pretta, E. Lai, N. Liscia, A. Lupi, E. Giglio, G. Palomba, M. Casula, M. Pisano, G. Palmieri, M. Scartozzi
Journal: Annals of Oncology (2021)
Precision-porous polyurethane elastomers engineered for application in pro-healing vascular grafts: Synthesis, fabrication and detailed biocompatibility assessment
Authors: Le Zhen, Sharon A. Creason, Felix I. Simonovsky, Jessica M. Snyder, Sarah L. Lindhartsen, Marvin M. Mecwan, Brian W. Johnson, Jonathan Himmelfarb, Buddy D. Ratner
Journal: Biomaterials (2021)
1535P Exploring the dynamic crosstalk between immune system and genetics in a cohort of 116 completely resected gastrointestinal stromal tumors (GISTs)
Authors: L. Incorvaia, G. Badalamenti, D. Fanale, C. Brando, L. Algeri, A. Dimino, R. Scalia, N. Barraco, M. Bono, E. Pedone, D. Cancelliere, A. Fiorino, A. Galvano, V. Gristina, A. Perez, F. Li Pomi, L.R. Corsini, A. Pivetti, V. Bazan, A. Russo
Journal: Annals of Oncology (2021)
813P Efficacy and safety of trastuzumab deruxtecan in HER2-expressing uterine carcinosarcoma (STATICE trial, NCCH1615): A multicenter, phase II clinical trial
Authors: K. Hasegawa, T. Nishikawa, A. Hirakawa, M. Kawasaki, S. Tomatsuri, Y. Nagasaka, K. Nakamura, K. Matsumoto, M. Mori, Y. Hirashima, K. Takehara, K. Ariyoshi, T. Kato, S. Yagishita, A. Hamada, H. Yoshida, K. Yonemori
Journal: Annals of Oncology (2021)
Appropriateness of Opioid Prescription in Children, Adolescents, and Younger Adults—The Elephant in the Room
Authors: Luisa Cortellazzo Wiel, Giorgio Cozzi, Egidio Barbi
Journal: JAMA Pediatrics (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
252P Does the introduction of CDK4/6 inhibitors (CDKi) in first-line treatment of metastatic breast cancer (MBC) increase medical oncology workload?
Authors: C. Noto, A. Dri, F. Pravisano, M. Residori, L. Bortot, S. Buriolla, G. Targato, C. Andreetta, G. Pascoletti, E. Poletto, S. Russo, M. Mansutti, A.M.M. Minisini, F. Puglisi, G. Fasola, M. Bonotto
Journal: Annals of Oncology (2021)
1477P Prognostic and predictive value of CA 19-9 in locally advanced pancreatic cancer treated with multi-agent induction chemotherapy: Results from a prospective, multicenter phase II trial (NEOLAP-AIO-PAK-0113)
Authors: I. Hartlapp, D. Valta-Seufzer, J. Siveke, H. Algül, E. Goekkurt, G.M. Siegler, U.M. Martens, D. Waldschmidt, U. Pelzer, M. Fuchs, F. Kullmann, S. Boeck, T.J. Ettrich, S. Held, R. Keller, F. Anger, C-T. Germer, H.A. Stang, V. Heinemann, V. Kunzmann
Journal: Annals of Oncology (2021)
Quantum decision corrections for the neuroeconomics of irrational movement control and goal attainment
Authors: Kevin B. Clark
Journal: Behavioral and Brain Sciences (2021)

Abstract Quantum decision theory corrects categorical and propositional logic pathologies common to classic statistical goal-oriented reasoning, such as rational neuroeconomics-based optimal foraging. Within this ecosalient framework, motivation, perception, learning, deliberation, brain computation, and conjunctive risk-order errors may be understood for subjective utility judgments underlying either rational or irrational canonical decisions-actions used to choose, procure, and consume rewarding nutrition with variable fitness.
856P A comparison of the burden of leukemia amongst European Union 15+ countries, 1990-2019
Authors: C.T. Jani, H. Singh, O. Al Omari, None G. hanbury, A. Kelaiya, J. Shalhoub, D. Marshall, L. Weissmann, J. Salciccioli
Journal: Annals of Oncology (2021)
Exposure to conflicts and the continuum of maternal healthcare: Analyses of pooled cross-sectional data for 452,192 women across 49 countries and 82 surveys
Authors: Anu Rammohan, Astghik Mavisakalyan, Loan Vu, Srinivas Goli
Journal: PLoS Medicine (2021)

Violent conflicts are observed in many parts of the world and have profound impacts on the lives of exposed individuals. The limited evidence available from specific country or region contexts suggest that conflict exposure may reduce health service utilization and have adverse affects on health. This study focused on identifying the association between conflict exposure and continuum of care (CoC) services that are crucial for achieving improvements in reproductive, maternal, newborn, and child health and nutrition (RMNCHN).
Abstract 14841: Effects of Surface Roughness on the Blood Flow in Calcified Arteries: A Fluid-Structure Interaction Model
Authors: Gorg Abdelmassih, Nina Kosciuszek, Gregory D Oliva, Dorinamaria Carka, Olga V Savinova
Journal: Circulation (2019)

Introduction: Calcification decreases the flex-elastic characteristics of the artery walls and associated with atherosclerosis. Genetically engineered calcification in mice increases the endothelia...
Import of multidrug-resistant bacteria from abroad through interhospital transfers, Finland, 2010–2019
Authors: Mikael Kajova, Tamim Khawaja, Jonas Kangas, Hilda Mäkinen, Anu Kantele
Journal: Eurosurveillance (2021)

Background While 20–80% of regular visitors to (sub)tropical regions become colonised by extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE), those hospitalised abroad often also carry other multidrug-resistant (MDR) bacteria on return; the rates are presumed to be highest for interhospital transfers. Aim This observational study assessed MDR bacterial colonisation among patients transferred directly from hospitals abroad to Helsinki University Hospital. We investigated predisposing factors, clinical infections and associated fatalities. Methods Data were derived from screening and from diagnostic samples collected between 2010 and 2019. Risk factors of colonisation were identified by multivariable analysis. Microbiologically verified symptomatic infections and infection-related mortality were recorded during post-transfer hospitalisation. Results Colonisation rates proved highest for transfers from Asia (69/96; 71.9%) and lowest for those within Europe (99/524; 18.9%). Of all 698 patients, 208 (29.8%) were colonised; among those, 163 (78.4%) carried ESBL-PE, 28 (13.5%) MDR Acinetobacter species, 25 (12.0%) meticillin-resistant Staphylococcus aureus , 25 (12.0%) vancomycin-resistant Enterococcus , 14 (6.7%) carbapenemase-producing Enterobacteriaceae , and 12 (5.8%) MDR Pseudomonas aeruginosa ; 46 strains tested carbapenemase gene-positive. In multivariable analysis, geographical region, intensive care unit (ICU) treatment and antibiotic use abroad proved to be risk factors for colonisation. Clinical MDR infections, two of them fatal (1.0%), were recorded for 22 of 208 (10.6%) MDR carriers. Conclusions Colonisation by MDR bacteria was common among patients transferred from foreign hospitals. Region of hospitalisation, ICU treatment and antibiotic use were identified as predisposing factors. Within 30 days after transfer, MDR colonisation manifested as clinical infection in more than 10% of the carriers.
750P Safety and efficacy of platinum desensitization treatment in patients with ovarian cancer and platinum hypersensitivity
Authors: A. Nuzzo, S. Manacorda, F. Paolieri, A. Sbrana, S. Bazzurri, E. Sammarco, F. Bloise, M. Ferrari, F. Manfredi, C. Mercinelli, A. Bonato, G. Massaro, A. Salfi, L. Galli, A. Antonuzzo, S. Cosio, A. Gadducci
Journal: Annals of Oncology (2021)
913P Apatinib for heavily pretreated recurrent and/or metastatic head and neck squamous cell carcinoma: Updated analysis
Authors: K. Yang, G. Peng, Y. Qin, J. Huang, Q. Ding, Z. Yang, Y. Dong, H. Zhou, F. Cao, G. Chen, L. Zhu
Journal: Annals of Oncology (2021)
485P A phase Ib study of cetuximab combined with fruquintinib in the previously treated RAS/BRAF wild-type metastatic colorectal cancer: The preliminary result of CEFRU study
Authors: Y. LI, X. Chen, Y.H. Liu, X. Qu, Y.S. Ye, S.D. Sun, Y.D. Chen, H.B. Zhang
Journal: Annals of Oncology (2021)
1543P Gemcitabine in classic Kaposi’s sarcoma: A pilot study
Authors: G. Badalamenti, L. Incorvaia, A. Bonasera, L. Algeri, A. Dimino, A. Cucinella, G. Madonia, R. Scalia, D. Fanale, F. Li Pomi, A. Galvano, V. Gristina, L.R. Corsini, C. Brando, V. Bazan, A. Russo
Journal: Annals of Oncology (2021)
239P Drug-drug interactions between palbociclib and proton pump inhibitors may significantly affect clinical outcome of metastatic breast cancer patients
Authors: M. Del Re, C. Omarini, L. Diodati, M. Palleschi, I. Meattini, S. Crucitta, C. Isca, S. Fogli, S. Bleve, G. Lorenzini, A. Fontana, L. Livi, F. Piacentini, U. De Giorgi, R. Danesi
Journal: Annals of Oncology (2021)
1660P Changes in the pattern of diagnosis and treatment of patients with SCLC in the last 20 years
Authors: A. Rios Hoyo, M. Hardy-Werbin, N. Navarro, L. Moliner, X. Durán, Á. Taus, S. González Gallardo, R. del Rey Vergara, M.A. Galindo Campos, E. Arriola
Journal: Annals of Oncology (2021)
Small Intestinal Submucosa Membrane Modified by Fusion Peptide‐Mediated Extracellular Vesicles to Promote Tissue Regeneration
Authors: Lei Zhang, Shiqing Ma, Pengfei Wei, Yifan Zhao, Yuzhu Mu, Jinzhe Wu, Wei Jing, Bo Zhao, Jiayin Deng, Zihao Liu
Journal: Advanced Healthcare Materials (2021)

Abstract Tissue injury, which often occurs in daily life, remains challenging in clinical medicine. Developing a novel biomaterial with the capability to provide an ideal microenvironment and homeostasis around the wound is highly desirable for effective tissue regenerative medicine. The small intestinal submucosa (SIS) membrane possesses a precise spatial structure with excellent biocompatibility. Extracellular vesicles (EVs) derived from umbilical cord mesenchymal stem cells can achieve rapid cell proliferation and migration with little immune response by creating a satisfactory microenvironment. In this study, fusion peptide‐mediated EVs are able to modify the surface of the SIS membrane via specific combination. In vitro studies prove that modified SIS membranes can promote cell migration and spreading. This phenomenon may be because of the activation of TEADs, which regulate cell behavior. By constructing a rat abdominal wall defect model, it is further demonstrated that the modified SIS membrane is more conducive to tissue regeneration. Collectively, these results suggest that SIS membranes modified by fusion peptide‐mediated EVs achieve excellent biofunction and provide promising prospects for tissue regeneration.
248P The implementation of CDK 4/6 inhibitors and its impact on treatment choices in HR+/HER2- advanced breast cancer patients: A study of the Dutch SONABRE registry
Authors: M. Meegdes, S.M.E. Geurts, F.L.G. Erdkamp, M.W. Dercksen, B.E.P.J. Vriens, K. Aaldering, M.J.A.E. Pepels, L.V.D. Winkel, N.J.A. Teeuwen, M. De Boer, V.C.G. Tjan-Heijnen
Journal: Annals of Oncology (2021)
1029TiP Phase II trial of pembrolizumab (pembro) and brentuximab vedotin (BV) in patients with metastatic solid malignancies after progression on prior programmed cell death protein (PD)-1 inhibitors (SGN35-033)
Authors: C.L. Cowey, J.A. Fiorillo, T. Larson, D.M. Waterhouse, M.F. Chaney, S. Knowles
Journal: Annals of Oncology (2021)
LBA34 Association of homologous recombination deficiency (HRD) with clinical outcomes in a phase III study of olaparib or cediranib and olaparib compared to platinum-based chemotherapy in recurrent platinum-sensitive ovarian cancer (PSOC): Biomarker analyses from NRG-GY004
Authors: E. Swisher, A. Miller, E. Kohn, M. Brady, M. Radke, C. Pennil, N. Khasnavis, J. Buscema, W. Tew, C. Muller, E. Hill, R. Moore, D. Michelin, S. Waggoner, M. Geller, K. Fujiwara, S. D'Andre, J. Liu, M.J. Birrer
Journal: Annals of Oncology (2021)
1266P Genetic profiling of cell-free DNA from pleural effusion in advanced lung cancer as a surrogate for tumor tissue and revealed additional clinical actionable targets
Authors: H-Y. Tu, Y-S. Li, X-Y. Bai, Y-L. Sun, M-Y. Zheng, R-Q. Liao, B-Y. Jiang, B-C. Wang, H-J. Chen, B-F. Xu, X. Tong, R. Yu, X. Wu, D. Zhu, J-J. Yang, X-C. Zhang, Q. Zhou, Y-L. Wu
Journal: Annals of Oncology (2021)
Postoperative speech impairment and surgical approach to posterior fossa tumours in children: a prospective European multicentre cohort study
Authors: Jonathan Kjær Grønbæk, Morten Wibroe, Sebastian Toescu, Radek Frič, Birthe Lykke Thomsen, Lisbeth Nørgaard Møller, Pernilla Grillner, Bengt Gustavsson, Conor Mallucci, Kristian Aquilina, Greg Adam Fellows, Emanuela Molinari, Magnus Aasved Hjort, Mia Westerholm-Ormio, Rosita Kiudeliene, Katalin Mudra, Peter Hauser, Kirsten van Baarsen, Eelco Hoving, Julian Zipfel, Karsten Nysom, Kjeld Schmiegelow, Astrid Sehested, Marianne Juhler, René Mathiasen, Jonathan Kjær Grønbæk, Morten Wibroe, Sebastian Toescu, Radek Frič, Lisbeth Nørgaard Møller, Pernilla Grillner, Bengt Gustavsson, Conor Mallucci, Kristian Aquilina, Emanuela Molinari, Magnus Aasved Hjort, Mia Westerholm-Ormio, Rosita Kiudeliene, Katalin Mudra, Peter Hauser, Kirsten van Baarsen, Eelco Hoving, Julian Zipfel, Karsten Nysom, Kjeld Schmiegelow, Astrid Sehested, Marianne Juhler, René Mathiasen, Mimi Kjærsgaard, Lars Bøgeskov, Jane Skjøth-Rasmussen, John Hauerberg Tamm, Lars Poulsgaard, Thora Gudrunardottir, Sylvester Kløcker Grønbæk, Alberte Blichfeldt, Felix Nicolai Raben-Levetzau, Michael Thude Callesen, Mathias Rathe, Rikke Bassø Klokker, Gorm von Oettingen, Torben Mikkelsen, Louise Tram Henriksen, Søren Cortnum, Kamilla Tofting-Olesen, Atte Karppinen, Kristin Solem, Ingrid Kristin Torsvik, Ann-Karin Mosand, Line Rapp Simonsen, Christoffer Ehrstedt, Ingela Kristiansen, Karin Fritzson, Line Balestrand Haga, Hege Kristine Fagerholt, Helene Stømqvist Blixt, Hanna Sundgren, Yvonne Håkansson, Charlotte Castor, Per Nyman, Anne Wretman, Pelle Nilsson, Ann-Christin Bjørklund, Magnus Sabel, Inga-Lill Haij, Frans Nilsson, Hanna Olausson, Claire Cummings, Jade Flemming, Deborah Afolabi, Kim Phipps, Ian Kamaly, Sharon Williams, Noor-ul-Owase Jeelani, Donald McArthur, Elisabeth Wiles, David Walker, Rebecca Cooper, Greg Fellows, Lizzy Hoole, Kirsty Slater, Jothy Kandasamy, Rachel McAndrew, Katie McLaughlin, Martin Schumann, Shivaram Avula, Barry Pizer, Giedre Rutkauskiene, Algimantas Matukevicius, Leonie van den Abbeele, Balázs Markia, Beatrix Pálmafy, Niels Clausen, Karen Margrethe Ottosen Møller, Harald Thomassen, Johan Cappelen, Einar Stensvold, Irene Devennay, Tuula Lønnqvist, Kristiina Nordfors, Päivi Lähteenmäki
Journal: The Lancet Child & Adolescent Health (2021)
1437TiP Phase Ib/II, open label, dose escalation and expansion trial of tucatinib in combination with trastuzumab and oxaliplatin-based chemotherapy in patients with unresectable or metastatic HER2+ gastrointestinal cancers (trial in Progress)
Authors: H. Park, T. Bekaii-Saab, S. Kim, S. Kamath, M. Pishvaian, J. Ford, D. Zhen, J. Mayor, C. Lux, Q. Tan, J. Strickler
Journal: Annals of Oncology (2021)
1267P Clinical utility of ctDNA for detection of EGFR, ALK, BRAFV600E alterations and resistance mutations in patients with NSCLC at failure to targeted therapy
Authors: M. Riudavets Melia, D. Vasseur, M. Aldea, V. Lamberts, M. Dorta Suarez, C. Naltet, C. Jovelet, A. Grecea, P. Martin Romano, L. Lacroix, P. Lavaud, A. Gazzah, C. Morris, K. Howarth, F. Barlesi, J-C. Soria, C. Massard, D. Planchard, B. Besse, L. Mezquita
Journal: Annals of Oncology (2021)
High dose coupled plasma filtration and adsorption in septic shock patients. Results of the COMPACT-2: a multicentre, adaptive, randomised clinical trial
Authors: Elena Garbero, Sergio Livigni, Fiorenza Ferrari, Stefano Finazzi, Martin Langer, Paolo Malacarne, Manlio Cosimo Claudio Meca, Sabino Mosca, Carlo Olivieri, Marco Pozzato, Carlotta Rossi, Mario Tavola, Marina Terzitta, Bruno Viaggi, Guido Bertolini, Valeria Bonato, Italo Calamai, Gilberto Fiore, Valentina Gori, Ugo Lefons, Sergio Livigni, Manlio Cosimo Claudio Meca, Stefano Meinardi, Giuseppe Nattino, Luisa Tedeschi, Marina Terzitta, Francesco Zuccaro
Journal: Intensive Care Medicine (2021)
Covid-19 in patients with chronic lymphocytic leukemia: clinical outcome and B- and T-cell immunity during 13 months in consecutive patients
Authors: Lisa Blixt, Gordana Bogdanovic, Marcus Buggert, Yu Gao, Sophia Hober, Katie Healy, Hemming Johansson, Christian Kjellander, Sara Mravinacova, Sandra Muschiol, Peter Nilsson, Marzia Palma, Elisa Pin, C. I. Edvard Smith, Olga Stromberg, Margaret Sällberg Chen, Rula Zain, Lotta Hansson, Anders Österborg
Journal: Leukemia (2021)

We studied clinical and immunological outcome of Covid-19 in consecutive CLL patients from a well-defined area during month 1-13 of the pandemic. Sixty patients (median age 71 y, range 43-97) were identified. Median CIRS was eight (4-20). Patients had indolent CLL (n = 38), had completed (n = 12) or ongoing therapy (n = 10). Forty-six patients (77%) were hospitalized due to severe Covid-19 and 11 were admitted to ICU. Severe Covid-19 was equally distributed across subgroups irrespective of age, gender, BMI, CLL status except CIRS (p < 0.05). Fourteen patients (23%) died; age ≥75 y was the only significant risk factor (p < 0.05, multivariate analysis with limited power). Comparing month 1-6 vs 7-13 of the pandemic, deaths were numerically reduced from 32% to 18%, ICU admission from 37% to 15% whereas hospitalizations remained frequent (86% vs 71%). Seroconversion occurred in 33/40 patients (82%) and anti-SARS-CoV-2 antibodies were detectable at six and 12 months in 17/22 and 8/11 patients, respectively. Most (13/17) had neutralizing antibodies and 19/28 had antibodies in saliva. SARS-CoV-2-specific T-cells (ELISpot) were detected in 14/17 patients. Covid-19 continued to result in high admission even among consecutive and young early- stage CLL patients. A robust and durable B and/or T cell immunity was observed in most convalescents.
1044P Sequential targeted and immunotherapies in stage IV melanoma
Authors: T.M.S. Amaral, J. Nolinski, H. Niessner, T. Sinnberg, O. Seeber, S. Sanchez, U. Keim, I. Thomas, A. Meiwes, A. Koechel, A. Forschner, U. Leiter, L. Flatz, T. Eigentler, C. Garbe
Journal: Annals of Oncology (2021)
51P Pooled analysis safety profile of futibatinib in patients with advanced solid tumors, including intrahepatic cholangiocarcinoma (iCCA)
Authors: F. Meric-Bernstam, J. Furuse, D-Y. Oh, J.A. Bridgewater, L. Goyal, R. Bahleda, K. Li, P. Patel, N. Soni, V. Wacheck, M. Moehler
Journal: Annals of Oncology (2021)
Abstract 174: Biophysical Basis of Protein Kinase C Inhibition of the Novel alpha1D Calcium Channel
Authors: Mohamed Chahine, Yongxia Qu, Mohamed Boutjdir
Journal: Circulation (2007)

The recently reported α 1D calcium channel in the heart is known to be regulated by protein kinase C (PKC) at the whole cell level and has been implicated in atrial fibrillation. The biophysical basis of this regulation at the single channel level is not known. Therefore, the effect of PKC activation was studied on α 1D calcium channel expressed in tsA201 cells using cell-attached method. Unitary currents were recorded in the presence of 70 mM Ba 2+ as the charge carrier. Unitary currents were evoked by 500 ms depolarizing pulses from a holding potential of −80 mV every 0.5 Hz. Under basal condition, channel activity was rare and infrequent, however Bay K 8644 (1 μM) induced channel openings with a conductance of 22.3 pS. Single channel analysis of open and closed time distributions were best fitted with a single exponential. PKC activation by PMA (10 nM), a phorbol ester derivative, resulted in a decrease in open probability and increase in closed-time without any significant effect on the conductance of the α 1D calcium channel. This is consistent with a decreased entry of α 1D Ca channel into open states in the presence of PMA. These data show, for the fist time, 1) the α 1D calcium channel activity at the single channel level and 2) the biophysical basis of by which PKC activation inhibits the α 1D calcium channel. The shortening of the open-time and the lengthening of the closed-time constants and the increase in blank sweeps may explain the inhibition of the α 1D Ca-channel activity and the reduction in whole-cell α 1D Ca current previously reported. Altogether, these data are relevant to the understanding of the patho-physiology of α 1D calcium channel and its regulation by the autonomics.
Effect of oral chlorhexidine de-adoption and implementation of an oral care bundle on mortality for mechanically ventilated patients in the intensive care unit (CHORAL): a multi-center stepped wedge cluster-randomized controlled trial
Authors: Craig M. Dale, Louise Rose, Sarah Carbone, Ruxandra Pinto, Orla M. Smith, Lisa Burry, Eddy Fan, Andre Carlos Kajdacsy-Balla Amaral, Victoria A. McCredie, Damon C. Scales, Brian H. Cuthbertson
Journal: Intensive Care Medicine (2021)
333TiP AMEERA-1: Phase I/II study of amcenestrant (SAR439859), an oral selective estrogen receptor (ER) degrader (SERD), with alpelisib in postmenopausal women with ER+/ human epidermal growth factor receptor 2-negative (HER2–) PIK3CA-mutated advanced breast cancer
Authors: M. Campone, A. Bardia, P. Kabos, S. Chandarlapaty, P. Neven, V. Boni, S. Lord, S. Cartot-Cotton, M. Celanovic, A. Gosselin, V. Pelekanou, H.M. Linden
Journal: Annals of Oncology (2021)
Clinical experience of IMGN901 (BB-10901) in patients with small cell lung carcinoma (SCLC)
Authors: Frank Fossella, Penella J. Woll, Paul Lorigan, Anthony Tolcher, Mary O'Brien, Jessica O'Keeffe, Sybil Zildjian, Albert Qin, James O'Leary, Miguel Villalona-Calero
Journal: Journal of Thoracic Oncology (2009)