tbuckley/cabot-search huggingface dataset:
Cardiovascular Disorders in Autoimmune Disease
Authors: Delcio G Silva Junior
Journal: Clinical Cardiology and Cardiovascular Interventions (2019)

The presence of Cardio Vascular Disease (CVD) impacts negatively on expectation and quality of life of the population, being one of the main causes of disability. Many of those who become cardiovascular patients throughout their life could have had different evolution if preventive attitudes were taken. Since 50’s decade, Framingham studies have shown the importance of predetermining factors for CVD occurrence. The classical CVD risk factors such as diabetes, metabolic syndrome, dyslipidemia, hypertension, smoking and family history are well established as predictors of cardiovascular events. The presence of Cardio Vascular Disease (CVD) impacts negatively on expectation and quality of life of the population, being one of the main causes of disability. Many of those who become cardiovascular patients throughout their life could have had different evolution if preventive attitudes were taken. Since 50’s decade, Framingham studies have shown the importance of predetermining factors for CVD occurrence. The classical CVD risk factors such as diabetes, metabolic syndrome, dyslipidemia, hypertension, smoking and family history are well established as predictors of cardiovascular events. However, in certain clinical conditions, traditional risk factors seem not to fully explain the incidence of CVD. Coronary artery disease and early atherosclerosis in young women with Systemic Lupus Erythematosus (SLE) are one of the best examples of how chronic inflammatory diseases can affect individuals who are normally poorly exposed to traditional risk factors. Even with the plurality of extra-articular manifestations of rheumatologic diseases, such as pulmonary hypertension and SLE encephalopathy, uveitis in spondyloarthritis, or as Achalasia in scleroderma, attention is being paid to the frequent cardiovascular system involvement in these patients, especially in the vascular territory
A Phase I/II Study of Venetoclax in Combination with ASTX727 (cedazuridine/decitabine) in Treatment-Naïve High-Risk Myelodysplastic Syndrome (MDS) or Chronic Myelomonocytic Leukemia (CMML)
Authors: Sangeetha Venugopal, Hagop Kantarjian, Abhishek Maiti, Nicholas J. Short, Guillermo Montalban-Bravo, Yesid Alvarado, Kelly S. Chien, Rashmi Kanagal-Shamanna, Naveen Pemmaraju, Naval Daver, Tapan M. Kadia, Gautam Borthakur, Elias J. Jabbour, Guillermo Garcia-Manero
Journal: Blood (2021)
Fludarabine Exposure Predicts Outcome after CD19 CAR T Cell Therapy in Children and Young Adults with Acute Leukemia; An Exploratory, Observational Study
Authors: Linde Dekker, Friso Calkoen, Yilin Jiang, Hilly Blok, Maike Spoon, Rick Admiraal, Peter Hoogerbrugge, Britta Julia Vormoor, Josef Vormoor, C. Michel Zwaan, Henk Visscher, Marc Bierings, Marieke Van Der Vlugt, Harm Van Tinteren, A. Laura Nijstad, Kim Van Der Elst, Alwin D. R. Huitema, Rob Pieters, Caroline Lindemans, Stefan Nierkens
Journal: Blood (2021)
DUSP6 Mediates Resistance to JAK2 Inhibition and Drives Myeloproliferative Neoplasm Disease Progression
Authors: Tim Kong, Angelo BA Laranjeira, Kangning Yang, Daniel AC Fisher, LaYow Yu, Anthony Z Wang, Marianna B. Ruzinova, Jared S. Fowles, Maggie J. Allen, Hamza Celik, Grant A. Challen, Sidong Huang, Stephen T. Oh
Journal: Blood (2021)
FISH-Guided Evaluation of Hyperdiploidy and Other Cytogenetic Abnormalities in Childhood Burkitt Lymphoma
Authors: Georgia Avgerinou, Maria Filippidou, Ioannis V Kostopoulos, Athanasios Exarchos, Kalliopi Stefanaki, Ilona Binenbaum, Konstantinos Liapis, Lydia Kossiva, Katerina Katsibardi, Sophia Polychronopoulou, Marina Mantzourani, Antonis Kattamis, Stefanos Papadhimitriou
Journal: Blood (2021)
PET-Guided Treatment in Patients with Early-Stage Favorable Hodgkin Lymphoma: Follow-up Analysis of the HD16 Trial By the German Hodgkin Study Group
Authors: Michael Fuchs, Anne Sophie Jacob, Helen Kaul, Carsten Kobe, Thomas Pabst, Richard Greil, Dennis A. Eichenauer, Max Topp, Marianne Just, Bernd Hertenstein, Valdete Schaub, Martin Vogelhuber, Josée M Zijlstra, Annette Plütschow, Christian Baues, Andreas Rosenwald, Markus Dietlein, Peter Borchmann, Andreas Engert
Journal: Blood (2021)
Salvage Therapy with Brentuximab-Vedotin and Bendamustine for Patients with Relapsed/Refractory T Cell Lymphoma. a Multicenter and Retrospective Study
Authors: Krimo Bouabdallah, Raphaëlle Aubrais, Loïc Chartier, Charles Herbaux, Anne Banos, Pauline Brice, Marlene Ochmann, David Sibon, Jean Marc Schiano De Colella, Thomas Cluzeau, Kamel Laribi, Ronan Le Calloch, Mathieu Bellal, Nicolas Daguindau, Sandy Amorim, Kossi Agbetiafa, Adrien Chauchet, Marwa Hammami, Eric Durot, Christophe Bonnet, Margot Robles, Ludovic Fouillet, Fontanet Bijou, Olivier Tournilhac, Philippe Gaulard, Marie Parrens, Noel-Jean Milpied, Gandhi Laurent Damaj
Journal: Blood (2021)
A Phase 2/3, Multicenter Randomized Study of Rituximab-Gemcitabine-Dexamethasone-Platinum (R-GDP) with or without Selinexor in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma (RR DLBCL)
Authors: Seung Tae Lee, Antonio Pinto, Habte Yimer, Don Stevens, Wanda Knopinska Posluszny, Merrill Kingman Shum, Sudhir Manda, Merav Leiba, Miguel Canales, Maciej Kaźmierczak, Wojciech Jurczak, Anna Sureda, Xiwen Ma, Kai Li, Kimberly Ingalls, Tara Arriola, Melina Arazy, Jatin J. Shah, Sharon Shacham, Michael G. Kauffman, Grzegorz S. Nowakowski
Journal: Blood (2021)
Characteristics of Patients with Central Nervous System Relapse in Veterans with Diffuse Large B-Cell Lymphoma within the Veterans Health Administration
Authors: Amy M Horowitz, Madison H. Williams, Ryan A. Williams, Jean Pierre Blaize, Snegha Ananth, Michael M. Song, Brian Warnecke, Abhishek Pandya, Lakene Raissa Djoufack Djoumessi, Phillip Nazarewicz, Manuel Ricardo Espinoza-Gutarra, Juan J. Toro, Lindsey Lu, Kana Tai Lucero, Jennifer Whitehead, Kathleen Franklin, Michael Mader, Zohra Nooruddin
Journal: Blood (2021)
Impact of Autologous Hematopoietic Cell Transplant (HCT) Followed By Dendritic Cell/Myeloma Fusion Vaccine with Lenalidomide Maintenance in Increasing Multiple Myeloma (MM) Immunity (BMT CTN 1401)
Authors: David J. Chung, Nina Shah, Dina Stroopinsky, Juan WU, Lina Bisharat, Natalie S. Callander, Brent R. Logan, Kenneth C. Anderson, Thinle Chodon, Meera Mohan, Steven Devine, Yvonne A. Efebera, Nancy Geller, Peiman Hematti, Leona A. Holmberg, Alan Howard, Bryon Johnson, Hillard M Lazarus, Ehsan Malek, Philip L. McCarthy, David H. McKenna, Adam M. Mendizabal, Nikhil C. Munshi, Lynn O'Donnell, Aaron P. Rapoport, Ajay K. Nooka, Jane Reese, Robert J. Soiffer, Lynne Uhl, Giulia Cheloni, Dimitra Karagkouni, Ioannis Vlachos, James W. Young, Jacalyn Rosenblatt, Edmund K. Waller, Marcelo C Pasquini, David Avigan
Journal: Blood (2021)
A Clinical Prognostic Index for Angioimmunoblastic T Cell Lymphoma in an Asian Multi-Centre Study
Authors: Esther Chang, Valerie Shiwen Yang, Shin Yeu Ong, Hilda Kang, Ya Hwee Tan, Jianbang Chiang, Eileen Yi Ling Poon, Nagavalli Somasundaram, Mohamad Farid, Tiffany Tang, Miriam Tao, Lay Poh Khoo, Choon Kiat Ong, Soon Thye Lim, Jason Yongsheng Chan
Journal: Blood (2021)
Multiplex Engineering of Human CD34+ HSPCs Enables Dual Gene Knock-out While Maintaining High Engraftment Potential and Safety
Authors: Nipul Patel, Michael Pettiglio, Christopher Cummins, Jeff Pimentel, Anjali Kapuria, Azita Ghodssi, Meltem Isik, Alejandra Falla, Ravindra Amunugama, Jessica Lisle, Shu Wang, Michelle Lin, John Lydeard, Gary Ge, Dane Hazelbaker, Elizabeth Paik, Tirtha Chakraborty
Journal: Blood (2021)
RNA-Sequencing Improves Diagnostics and Treatment of Pediatric Hematological Malignancies
Authors: Marco J. Koudijs, Lennart A. Kester, Jayne Y. Hehir-Kwa, Eugene T.P. Verwiel, Erik Strengman, Marc van Tuil, Douwe van der Leest, Edwin Sonneveld, Patrick Kemmeren, Valerie De Haas, Josef Vormoor, Bas B.J. Tops
Journal: Blood (2021)
Profound B-Cell Lymphopenia Is a Major Factor Predicting Poor Humoral Response after BNT162b2 mRNA Sars-Cov-2 Vaccines in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation
Authors: Maxime Jullien, Amandine Le Bourgeois, Marianne Coste-Burel, Pierre Peterlin, Alice Garnier, Marie Audrain, Marie Rimbert, Berthe Marie Imbert, Thomas Drumel, Steven Le Gouill, Philippe Moreau, Béatrice Mahé, Viviane Dubruille, Nicolas Blin, Anne Lok, Cyrille Touzeau, Thomas Gastinne, Benoit Tessoulin, Sophie Vantyghem, Marie C Béné, Thierry Guillaume, Patrice Chevallier
Journal: Blood (2021)
Abstract 9060: Do Women Fare Differently After Repair of Acute Type a Aortic Dissection?
Authors: Stevan S Pupovac, Jonathan M Hemli, Michael Catalano, S J Scheinerman, Alan R Hartman, Derek R Brinster, Pey-Jen Yu
Journal: Circulation (2021)

Introduction: Given that the data regarding sex-based differences in presentation, management and outcomes following repair of acute type A aortic dissection (ATAAD) is sparse and inconsistent, we sought to examine the contemporary practice pattern and outcomes of ATAAD repair in females, as compared with men. Hypothesis: We hypothesize that female patients undergoing surgical repair of acute type A aortic dissection will have 30-day morbidity and mortality rates comparable to their matched control male peers, although this may be impacted by age; sex, body mass index, advanced age, hemodynamic instability at clinical presentation, and presence of a preoperative malperfusion syndrome, are all independent risk factors for poorer short-term outcomes.. Methods: Out of 240 cases of ATAAD between June 2014 and December 2019, 231 patients were divided into 2 groups based on sex. From this, 47 pairs of propensity-matched patients were analyzed with respect to operative data and short-term clinical outcomes. Results: Overall 30-day mortality for our entire study cohort was 11.8% (27 deaths), significantly greater in females (21.4%, 15 deaths vs. 7.5%, 12 deaths, P = 0.002); this difference was not observed in the matched cohort (19.1%, 9 deaths vs. 8.5%, 4 deaths, P = 0.14). Women more commonly undergo isolated replacement of the ascending aorta (78.7% vs. 59.6%, P &lt; 0.001), whereas aortic root replacement is performed more frequently males (53.2% vs. 19.1%, P &lt; 0.001). There is no significant difference in the incidence of major postoperative morbidity between sexes. Advanced age is associated with great 30-day mortality after ATAAD repair (OR 1.93). Conclusions: The significant difference in 30-day mortality observed in the overall cohort, was not observed in the matched cohort. This may suggest that the overall difference in outcomes with regards to sex, is secondary to the differences seen in age and presentation and not inherent to sex itself.
Abstract 9061: Aortic Wall Stress Across Risk Groupings of Aortic Size and Height Indices in a Male Veteran Population With Ascending Thoracic Aortic Aneurysm
Authors: Siavash Zamirpour, Yue Xuan, Zhongjie Wang, Axel Gomez, Michael D Hope, Joseph Leach, David A Saloner, Julius M Guccione, Liang Ge, Elaine E Tseng
Journal: Circulation (2021)

Introduction: Natural history studies of ascending thoracic aortic aneurysm (aTAA) identified maximum diameter as a predictor of aortic dissection, informing guidelines for prophylactic surgery. Studies have since challenged the biomechanical basis of diameter-based risk assessment. Indices of diameter with measures of body size were proposed to account for individual variation in diameter, including body surface area as aortic size index (ASI) or height as aortic height index (AHI). The goal of this study was to determine differences in aneurysm wall stresses across previously defined clinical risk groups for ASI and AHI. Methods: Height and weight measurements were retrospectively reviewed for 264 male veterans with aTAA. Wall stresses were previously simulated using finite element analyses on patient-specific geometries. Group differences in wall stress were assessed among ASI and AHI risk groups using the Kruskal-Wallis and Dunn tests. Results: Median ± interquartile range circumferential stresses among ASI risk groups were 486.5 ± 132.8, 510.7 ± 140.5, and 617.2 ± 201.6 kPa for groups 1-3 ( P = .19). Longitudinal stresses were 307.3 ± 70.8, 300.8 ± 67.9, and 359.1 ± 57.2 kPa ( P = .09). Among AHI risk groups, circumferential stresses were 476.9 ± 151.4, 503.3 ± 135.4, and 586.2 ± 102.6 kPa for groups 1-3 ( P = .008). Longitudinal stresses were 297.6 ± 80.7, 304.1 ± 64.7, and 361.2 ± 122.9 kPa ( P = .004). For both circumferential and longitudinal stresses, pairwise comparisons were significant between groups 1,3 and 2,3. No observations were classified as group 4 for ASI or AHI. Conclusions: Differences in wall stress were not significant across ASI risk groups and were significant between AHI groups 1,3 and 2,3. While both indices have been shown to stratify clinical outcomes, AHI-based risk groups may better reflect differences in biomechanical state. Prospective studies may further elucidate the relationship between biomechanical status and clinical outcomes.
Abstract 8909: High Hospital-Specific Postoperative Troponin Testing Intensity Was Associated With Improved Outcomes After Major Vascular Surgery
Authors: Paymon M Azizi, Duminda N Wijeysundera, Harindra C Wijeysundera, Peter Austin, Angela Jerath, Lu Han, Maria Koh, Ahmed Kayssi, Dennis T Ko
Journal: Circulation (2021)

Background: Acute myocardial injury after non-cardiac surgery is associated with increased mortality and cardiovascular morbidity, but it is not known if systematic postoperative troponin testing will lead to improved patient outcomes. Methods: We defined a cohort of vascular surgery patients in Ontario, Canada from January 1, 2010 to December 31, 2017. Hospital-level troponin testing intensity (classified into tertiles) was determined by the proportion of patients that received postoperative troponin testing. Cox proportional hazards modeling was used to assess the association (expressed as hazard ratio [HR]) between hospital-specific testing intensity with 30-day and 1-year major adverse cardiovascular outcomes (MACE) while adjusting for patient-, surgery-, and hospital-level factors. MACE was defined as all-cause mortality, myocardial infarction, or coronary revascularization. Rates of postoperative consultations and new filled prescription medications (≥65y) were also assessed. Results: The cohort consisted of 18,467 patients. Mean age was 72y (SD9) and 74.0% were male. The proportion of patients that received postoperative troponin testing were 77.5%, 35.8%, and 21.6% in the high, medium, and low testing intensity groups, respectively. At 30-days, 5.3%, 5.3% and 6.5% of patients in high, medium, and low testing intensity group experienced MACE, respectively. Compared with low-testing intensity, high-testing intensity was associated with a lower hazard of 30-day MACE (HR 0.71; 95%CI 0.57-0.89) and at 1-year (HR 0.83; 95%CI 0.72-0.94; Figure 1). High testing intensity hospitals had higher rates of postoperative cardiology and internal medicine consults and higher rates of new prescription medications filled. Conclusion: Patients undergoing vascular surgery at hospitals with higher postoperative troponin testing intensity had better 30-day and 1-year outcomes than patients who had surgery at hospitals with lower testing intensity.
Pulmonary Hypertension Is Associated with Poor Outcomes in Patients with Myeloproliferative Neoplasms and Cardiovascular Disease
Authors: Orly Leiva, Siyang Ren, Donna S. Neuberg, Ankeet Bhatt, Andrew Jenkins, Rachel P. Rosovsky, Rebecca Karp Leaf, Katayoon Goodarzi, Gabriela Hobbs
Journal: Blood (2021)
Cost Analysis of ACUTE Care Resource Utilization Among Individuals with Sickle Cell Disease in a Middle-Income Country
Authors: Clarisse Lobo, Jane S Hankins, Nickhill Bhakta, Emilia Nascimento, Patricia Gomes Moura, Delaine Fidlarczyk, Thais Oliveira Figueiredo, Roberto Barbosa, Jane Duran
Journal: Blood (2021)
Protection against autoimmunity is driven by thymic epithelial cell–mediated regulation of T<sub>reg</sub>development
Authors: Claudia Haftmann, Pascale Zwicky, Florian Ingelfinger, Florian Mair, Stefan Floess, René Riedel, Pawel Durek, Marianne R. Spalinger, Ekaterina Friebel, Brian P. Leung, Mirjam Lutz, Nicole Puertas, Ana Amorim, Stefanie Schärli, Benedict Becher, Jan Kisielow, Ari Waisman, Mir-Farzin Mashreghi, Jochen Huehn, Burkhard Becher
Journal: Science Immunology (2021)

Thymic education of regulatory T cells is more important than negative selection in the prevention of autoimmunity.
Superior Outcomes in Hispanic Patients Compared to Non-Hispanic Patients with Ph-Negative Acute Lymphoblastic Leukemia Using the Modified Pediatric-Based University of Southern California Acute Lymphoblastic Leukemia (USC ALL) Regimen for Newly Diagnosed ALL Patients in the Era of Novel Agents; A Retrospective Study
Authors: Vincent Louie Ramos Mendiola, Catherine Ly, Thuy Bui, Jennifer Wang, Jack Rodman, Karrune Woan, Eric Tam, Maria E. Vergara-Lluri, Preet M. Chaudhary, Dan Douer, Abdullah Ladha, George Yaghmour
Journal: Blood (2021)
Characterizing Naked Nuclei Frequency and Movement in Primary AML Cell Culture Using an ECM-Based Model
Authors: Shireen J. Usman, Thomas Conley, Hannah E. Whitehead, Wojciech Wojciechowski, Kaye Thomas, Dan Bergstralh, Andrea M. Baran, Andrew G Evans, Yurong Gao, Charles C. Chu, Hani Awad, Jason H. Mendler, Michael W. Becker, Omar S. Aljitawi
Journal: Blood (2021)
Abstract 9415: Body Mass Index, Waist Circumference and Waist-Hip Ratio in South Asians With Acute Coronary Syndrome
Authors: Parackrama Karunathilake, Prabhashini Kumarihamy, Sujeewa Gunaratne, Dammika Ranasinghe, Charith Bandara, Udaya Ralapanawa
Journal: Circulation (2021)

Introduction: Acute coronary syndrome (ACS) is the leading cause of death worldwide, even higher in South Asian countries. South Asia shows a higher incidence of ACS and an increasing trend of overweight and obesity. Methods: This cross-sectional descriptive study was conducted at the Teaching Hospital Peradeniya, Sri Lanka, among the patients presenting with ACS. An interviewer-administered structured questionnaire was used to collect data and to take anthropometric measurements. They were analysed to obtain the body mass index (BMI) and the waist-hip ratio. Results: A total of 780 patients with ACS were included in the study with a mean age of 60.8 ± 11.3 years. Among them, 316 (40.5%) were females. The mean BMI of females was 25.2 ± 4.4 kg m -2 which was higher than that of males 23.9 ± 3.8 kg m -2 , showing a statistically significant difference (p=0.003). The prevalence of overweight and obesity was 37.6% and 21.2%, respectively, significantly higher than the normal values for the ordinary Sri Lankan population (p=0.002). In females, the prevalence of obesity (31.2%) was significantly higher than in males (13.5%) (p=0.000). In males, the prevalence of overweight (40.6%) was significantly higher than in females (33.8%) (p=0.000). The mean waist circumference and waist-hip ratio in females were 88.8 ± 13.8 cm and 0.93 ± 0.10, respectively, which were significantly above the cut-off values for the risk of metabolic complications for South Asians 80 cm (p=0.000) and 0.85 (p=0.000). In males, the mean waist circumference was 86.9 ± 12.9 cm, significantly below the cut-off value for the South Asians (p=0.009), and the mean waist-hip ratio was 0.98, significantly above the cut-off point for South Asians (p=0.000). Conclusions: The proportion of overweight and obesity is significantly higher among the South Asians with ACS than the average South Asian population, confirming them as risk factors for cardiovascular diseases. In females, obesity is more associated with the development of ACS than in males. A higher waist circumference and the waist-hip ratio has an excellent predictive value of ACS in females. However, in males, though the waist-hip ratio has an excellent predictive value of ACS, waist circumference shows a negative correlation.
Deterministic Cell Separation Recovers &amp;gt;2-Fold T Cells, and More Naïve T Cells, for Autologous Cell Therapy As Compared to Centrifugally Prepared Cells
Authors: Yasna Behmardi, Laurissa Ouaguia, Laura Jean Healey, MinJung Kim, Cole Jones, Hani Rahmo, Alison Skelley, Khushroo Gandhi, Roberto Campos-Gonzalez, Curt I Civin, Tony Ward
Journal: Blood (2021)
Dependence on Bcl6 and Blimp1 drive distinct differentiation of murine memory and follicular helper CD4+ T cells
Authors: Thomas Ciucci, Melanie S. Vacchio, Ting Chen, Jia Nie, Laura B. Chopp, Dorian B. McGavern, Michael C. Kelly, Rémy Bosselut
Journal: The Journal of Experimental Medicine (2021)

During the immune response, CD4+ T cells differentiate into distinct effector subtypes, including follicular helper T (Tfh) cells that help B cells, and into memory cells. Tfh and memory cells are required for long-term immunity; both depend on the transcription factor Bcl6, raising the question whether they differentiate through similar mechanisms. Here, using single-cell RNA and ATAC sequencing, we show that virus-responding CD4+ T cells lacking both Bcl6 and Blimp1 can differentiate into cells with transcriptomic, chromatin accessibility, and functional attributes of memory cells but not of Tfh cells. Thus, Bcl6 promotes memory cell differentiation primarily through its repression of Blimp1. These findings demonstrate that distinct mechanisms underpin the differentiation of memory and Tfh CD4+ cells and define the Bcl6–Blimp1 axis as a potential target for promoting long-term memory T cell differentiation.
LILRB3 supports acute myeloid leukemia development and regulates T-cell antitumor immune responses through the TRAF2–cFLIP–NF-κB signaling axis
Authors: Guojin Wu, Yixiang Xu, Robbie D. Schultz, Heyu Chen, Jingjing Xie, Mi Deng, Xiaoye Liu, Xun Gui, Samuel John, Zhigang Lu, Hisashi Arase, Ningyan Zhang, Zhiqiang An, Cheng Cheng Zhang
Journal: Nature Cancer (2021)
Clinically Undetectable Heart Sounds in Hospitalized Patients Undergoing Echocardiography
Authors: Nancy Jariwala, Sydney Czako, Lindsey Brenton, Audrey Doherty, Karandeep Singh, Seth Klapman, Jonathon McBride
Journal: JAMA Internal Medicine (2021)

This cross-sectional study examines undetectable heart sounds in hospitalized patients who are undergoing echocardiography and evaluates the association between patient factors and missed valvular heart disease diagnoses.