tbuckley/cabot-search huggingface dataset:
LAP2α preserves genome integrity through assisting RPA deposition on damaged chromatin
Authors: Kaiwen Bao, Qi Zhang, Shuai Liu, Nan Song, Qiushi Guo, Ling Liu, Shanshan Tian, Jihui Hao, Yi Zhu, Kai Zhang, Ding Ai, Jie Yang, Zhi Yao, Roland Foisner, Lei Shi
Journal: Genome biology (2022)

Single-stranded DNA (ssDNA) coated with replication protein A (RPA) acts as a key platform for the recruitment and exchange of genome maintenance factors in DNA damage response. Yet, how the formation of the ssDNA-RPA intermediate is regulated remains elusive.
Menière's defies clinical research efforts at cure
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
2020 年银屑病生物治疗指南
Journal: British Journal of Dermatology (2020)

“生物制剂”是从活细胞中提取的基于蛋白质的药物，旨在靶向银屑病中免疫系统过度活跃的特定区域，其中包括肿瘤坏死因子 (TNF) 和白细胞介素 (IL) 17 和 23。现在有 11 种经许可和 NICE 批准的生物制剂用于治疗银屑病。该 2020 年循证指南由英国皮肤科医师协会的多利益相关者指南小组制定，并提供了如何有效、安全地使用这些重要药物以最大限度地提高患者利益的建议。
Possible role of tumor necrosis factor‐alpha in erythropoietic suppression by endotoxin and granulocyte/macrophage colony‐stimulating factor
Authors: K.B. Udupa, B.G. Sharma
Journal: American Journal of Hematology (1996)

Injection of bacterial endotoxin or granulocyte/macrophage colony-stimulating factor (GM-CSF) into exhypoxic polycythemic mice simultaneously with erythropoietin (EPO) suppressed erythroid cell formation, as monitored by 59Fe incorporation into circulating red blood cells. This effect was dose-dependent and time-dependent. GM-CSF did not inhibit erythroid cell formation directly, as the antibody to the GM-CSF did not neutralize the effect of endotoxin, the inducer of GM-CSF. The suppression of both agents could be partially corrected by prior injection of a monoclonal antibody to tumor necrosis factor α (anti-TNFα). These results indicate that the suppression of EPO-induced erythroid cell formation by endotoxin and GM-CSF was due in part to the production of TNFα. © 1996 Wiley-Liss, Inc.
Endoscopic band ligation for the removal of colonic polyp invading the diverticulum
Authors: Kenichiro Okimoto, Tomoaki Matsumura, Naoki Akizue, Yuki Ohta, Takashi Taida, Jun Kato, Naoya Kato
Journal: Endoscopy (2022)

Endoscopic mucosal resection (EMR) is one of the primary treatment approaches for colonic polyps [1] [2]. However, polyps invading the colonic diverticulum are difficult to identify on whole endoscopic images, making EMR or endoscopic submucosal dissection (ESD) difficult. Moreover, perforation may occur during EMR or ESD for this type of polyp. Endoscopic full-thickness resection can be an alternative approach, albeit costly. Endoscopic band ligation (EBL) is a simple and effective modality to prevent colonic diverticular hemorrhage [3] [4] [5]. Here, we present the utility of EBL for the removal of colonic polyps invading the diverticulum.
Charaka Samhita.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tidsskrift for den Norske Laegeforening, Oslo
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review Diseases of the Gallbladder and Bile Ducts . By Waltman Walters, B.S., M.D., M.S., Sc.D., and Albert M. Snell, B.S., M.D., M.S. 8°, cloth, 645 pp., with 342 illustrations. Philadelphia: W. B. Saunders Company, 1940. $10.00.
Journal: New England Journal of Medicine (1940)
Clarification of Skin Cream Function
Authors: Peter Wolf, Pablo Vieyra-Garcia
Journal: JAMA Dermatology (2019)

tial response in induction phase in panel B. In addition, because of percentage miscalculations, the percentage of the 3 patients without an MF score reduction erroneously reported as "23%" should be "12%," and the percentage calculation for the 15 of 21 patients for which a predominant T-cell clone was detected reported as "72%" should be "71%."There was an additional error for the range (maximum) of mSWAT scores for the complete responders; in the Abstract and Table, the correct data are "18.6 (1-66)" instead of "18.6 (1-47)."These errors, once corrected, 2 do not affect our conclusions: the trial demonstrates that low-dose, low-frequency PUVA appears to be effective and that maintenance treatment may extend disease-free remission.These errors are in addition to the previous errors for which a Correction notice has been published. 3We now confirm that there are no other errors in this article.
Health Status of and Intervention for US-Bound Kosovar Refugees—Fort Dix, New Jersey, May-July 1999
Journal: JAMA (1999)

In March 1999, as a result of armed conflict in the Kosovo province of the Federal Republic of Yugoslavia, approximately 860,000 ethnic Albanians sought refuge in neighboring Albania, the Former Yugoslav Republic of Macedonia (FYROM), the Republic of Montenegro--Federal Republic of Yugoslavia, and Bosnia-Herzegovina. As a result of massive refugee movement into FYROM, many nations, including the United States, accepted refugees for resettlement. Refugee processing centers were established in FYROM and the United States. In the United States, the Migration Health Assessment (MHA) of refugees was undertaken at Fort Dix, New Jersey (i.e., Operation Provide Refuge), in collaboration with the Office of Emergency Preparedness (OEP), Public Health Service, under the direction of the Office of Refugee Resettlement, U.S. Department of Health and Human Services. Assessments in Skopje, FYROM, were conducted by the International Organization for Migration. This report summarizes the results of collaboration between OEP and CDC to provide preventive health programs for 4045 Kosovar refugees at Fort Dix during a 10-week period, which found that the refugees were in good health and underscores the need for a tailored intervention program targeted at the health conditions of the specific population.
Update: Influenza Activity — United States and Worldwide, May 22–September 10, 2016
Authors: Alicia Budd, Lenee Blanton, Krista Kniss, Sophie Smith, Desiree Mustaquim, Stacy L. Davlin, Natalie Kramer, Brendan Flannery, Alicia M. Fry, Lisa A. Grohskopf, Sonja J. Olsen, Joseph Bresee, Wendy Sessions, Rebecca Garten, Xiyan Xu, Anwar Isa Abd Elal, Larisa Gubareva, John Barnes, David E. Wentworth, Erin Burns, Jacqueline Katz, Daniel Jernigan, Lynnette Brammer
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

During October 2000-May 2001, influenza A (H1N1), A (H3N2), and B viruses were identified in the Northern Hemisphere. Influenza A (H1N1) and B viruses circulated widely; influenza A (H3N2) viruses were reported infrequently and were not associated with widespread outbreaks in any country during October 2000-May 2001. Since May 2001, influenza A (H1N1) and B viruses have predominated in Asia and Oceania; influenza A (H3N2) and B viruses have predominated in Africa and South America. This report summarizes influenza activity in the United States* (1) and worldwide during May-September 25; influenza A (H1N1), A (H3N2), and B viruses continued to circulate worldwide and were associated with mild to moderate levels of activity. This activity underscores the need to follow the recommendations of the Advisory Committee on Immunization Practices (ACIP) (2,3) for the timely vaccination of persons at high risk for influenza-related complications.
Dissecting Aneurysms
Authors: C. Rob, J. R. Kenyon
Journal: BMJ (1960)

FIBRILLATION BRDIIISH .~~~~~~~~~~~~~~~~~~~~~~~itDCLJUtAskeletal muscle protects the cardiac muscle from fibrillation.Energy is required to maintain its length, for when there is lack of oxygen or glucose, or in the presence of metabolic inhibitors, the action potential is shortened and fibrillation is facilitated.
Finding Pulmonary Arterial Hypertension—Switching to Offense to Mitigate Disease Burden
Authors: Bradley A. Maron, Marc Humbert
Journal: JAMA Cardiology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Rapid Decline of Ceftazidime Resistance in Antibiotic-Free and Sublethal Environments Is Contingent on Genetic Background
Authors: Sara Hernando-Amado, Pablo Laborda, José Ramón Valverde, José Luis Martínez
Journal: Molecular Biology and Evolution (2022)

Abstract Trade-offs of antibiotic resistance evolution, such as fitness cost and collateral sensitivity (CS), could be exploited to drive evolution toward antibiotic susceptibility. Decline of resistance may occur when resistance to other drug leads to CS to the first one and when compensatory mutations, or genetic reversion of the original ones, reduce fitness cost. Here we describe the impact of antibiotic-free and sublethal environments on declining ceftazidime resistance in different Pseudomonas aeruginosa resistant mutants. We determined that decline of ceftazidime resistance occurs within 450 generations, which is caused by newly acquired mutations and not by reversion of the original ones, and that the original CS of these mutants is preserved. In addition, we observed that the frequency and degree of this decline is contingent on genetic background. Our results are relevant to implement evolution-based therapeutic approaches, as well as to redefine global policies of antibiotic use, such as drug cycling.
Efficacy and Safety of K-877 (Pemafibrate), a Selective PPARα Modulator, in European Patients on Statin Therapy
Authors: Henry N. Ginsberg, Neil J. Hounslow, Yusuke Senko, Hideki Suganami, Pawel Bogdanski, Richard Ceska, Akos Kalina, Roman A. Libis, Tatiana V. Supryadkina, G. Kees Hovingh
Journal: Diabetes Care (2022)

High plasma triglyceride (TG) is an independent risk factor for cardiovascular disease. Fibrates lower TG levels through peroxisome proliferator-activated receptor α (PPARα) agonism. Currently available fibrates, however, have relatively low selectivity for PPARα. The aim of this trial was to assess the safety, tolerability, and efficacy of K-877 (pemafibrate), a selective PPARα modulator, in statin-treated European patients with hypertriglyceridemia.A total of 408 statin-treated adults were recruited from 68 European sites for this phase 2, randomized, double-blind, placebo-controlled trial. They had fasting TG between 175 and 500 mg/dL and HDL-cholesterol (HDL-C) ≤50 mg/dL for men and ≤55 mg/dL for women. Participants were randomly assigned to receive placebo or one of six pemafibrate regimens: 0.05 mg twice a day, 0.1 mg twice a day, 0.2 mg twice a day, 0.1 mg once daily, 0.2 mg once daily, or 0.4 mg once daily. The primary end points were TG and non-HDL-C level lowering at week 12.Pemafibrate reduced TG at all doses (adjusted P value <0.001), with the greatest placebo-corrected reduction from baseline to week 12 observed in the 0.2-mg twice a day treatment group (54.4%). Reductions in non-HDL-C did not reach statistical significance. Reductions in TG were associated with improvements in other markers for TG-rich lipoprotein metabolism, including reductions in apoB48, apoCIII, and remnant cholesterol and an increase in HDL-C levels. Pemafibrate increased LDL-cholesterol levels, whereas apoB100 was unchanged. Pemafibrate was safe and well-tolerated, with only minor increases in serum creatinine and homocysteine concentrations.Pemafibrate is effective, safe, and well-tolerated for the reduction of TG in European populations with hypertriglyceridemia despite statin treatment.
Incorrect Wording.
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prevalence of multiple sclerosis in north-east Scotland.
Authors: D I Shepherd, A W Downie
Journal: BMJ (1978)

An epidemiological study of multiple sclerosis (MS) in north-east Scotland was carried out based on data correct on 1 December 1970. The prevalence of MS was 127 cases/100 000 population, which is greater than in any other surveyed area with a comparable population. The disease was not spread homogeneously within the region, and in one district one in 400 people was affected. The geographical distributions of MS and the presence of HLA antigens A3 and B7,which are associated with the disease, are remarkably similar, and the prevalence of B7 in north-east Scotland is higher than elsewhere. This may partly explain the high prevalence of MS in this area, but the essential additional environmental factor remains to be established.
A novel approach for relapsed/refractory FLT3mut+ acute myeloid leukaemia: synergistic effect of the combination of bispecific FLT3scFv/NKG2D-CAR T cells and gilteritinib
Authors: Ke-xin Li, Hui-yang Wu, Wan-ying Pan, Meng-qi Guo, De-zhi Qiu, Yan-jie He, Yu-hua Li, Dong-Hua Yang, Yu-xian Huang
Journal: Molecular Cancer (2022)

Abstract Background Patients with relapsed/refractory acute myeloid leukaemia (AML) with FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) have limited treatment options and poor prognosis. Therefore, novel treatment modalities are needed. Since high expression of natural killer group 2 member D ligands (NKG2DLs) can be induced by FLT3 inhibitors, we constructed dual-target FLT3 single-chain fragment variable (scFv)/NKG2D-chimeric antigen receptor (CAR) T cells, and explored whether FLT3 inhibitors combined with FLT3scFv/NKG2D-CAR T cells could have synergistic anti-leukaemia effects. Methods FLT3scFv and NKG2D expression in CAR T cells, FLT3 and NKG2DL expression in AML cells, and the in vitro cytotoxicity of combining CAR T cells with gilteritinib were assessed by flow cytometry. The therapeutic effect was evaluated in a xenograft mouse model established by injection of MOLM-13 cells. Mechanisms underlying the gilteritinib-induced NKG2DL upregulation were investigated using siRNA, ChIP-QPCR and luciferase assays. Results The FLT3scFv/NKG2D-CAR T cells specifically lysed AML cells both in vitro and in the xenograft mouse model. The efficacy of FLT3scFv/NKG2D-CAR T cells was improved by gilteritinib-pretreatment. The noncanonical NF-κB2/Rel B signalling pathway was found to mediate gilteritinib-induced NKG2DL upregulation in AML cells. Conclusions Bispecific FLT3scFv/NKG2D-CAR T cells can effectively eradicate AML cells. The FLT3 inhibitor gilteritinib can synergistically improve this effect by upregulating NF-κB2-dependent NKG2DL expression in AML cells. Graphical Abstract
Machine learning for technical skill assessment in surgery: a systematic review
Authors: Kyle Lam, Junhong Chen, Zeyu Wang, Fahad M. Iqbal, Ara Darzi, Benny Lo, Sanjay Purkayastha, James M. Kinross
Journal: npj Digital Medicine (2022)

Accurate and objective performance assessment is essential for both trainees and certified surgeons. However, existing methods can be time consuming, labor intensive, and subject to bias. Machine learning (ML) has the potential to provide rapid, automated, and reproducible feedback without the need for expert reviewers. We aimed to systematically review the literature and determine the ML techniques used for technical surgical skill assessment and identify challenges and barriers in the field. A systematic literature search, in accordance with the PRISMA statement, was performed to identify studies detailing the use of ML for technical skill assessment in surgery. Of the 1896 studies that were retrieved, 66 studies were included. The most common ML methods used were Hidden Markov Models (HMM, 14/66), Support Vector Machines (SVM, 17/66), and Artificial Neural Networks (ANN, 17/66). 40/66 studies used kinematic data, 19/66 used video or image data, and 7/66 used both. Studies assessed the performance of benchtop tasks (48/66), simulator tasks (10/66), and real-life surgery (8/66). Accuracy rates of over 80% were achieved, although tasks and participants varied between studies. Barriers to progress in the field included a focus on basic tasks, lack of standardization between studies, and lack of datasets. ML has the potential to produce accurate and objective surgical skill assessment through the use of methods including HMM, SVM, and ANN. Future ML-based assessment tools should move beyond the assessment of basic tasks and towards real-life surgery and provide interpretable feedback with clinical value for the surgeon.PROSPERO: CRD42020226071.
Pulmonary
Authors: M. Todorovič-Guid, L. Žic, Z. Kanič, S. Burja, K. Bračič, A. Piotrowski, P. Krajewski, P. Czech, P. Kawczyński, P. Stengert, J. van der Deure, G. C. Markhorst, K. Haasnoot, Fumimaro Hatori, Haruo Uchida, Masao Katayama, Rika Muto, H. M. Grubbauer, R. Kerbl, H. Litscher, G. Zobel, M. Trop, P. Jouvet, P. Hubert, D. Isabey, D. Pinquier, E. Dahan, M. Cloup, A. Harf, A. C. P. Ferreira, W. B. Carvalho, B. I. Kopelman, J. H. Lee, A. P. Kolesnichenko, O. B. Milenin, A. I. Gritsan, I. V. Kuznetsova, L. Albano, A. Panigazzi, L. Saligari, D. Capra, A. Reta, P. Engardt, M. Alderete, J. Fraser, A. Pengilly, Q. Mok, John Pope, David Birnkrant, James Martin, Anthony Repucci, J. F. Germain, B. Thebaud, C. Farnoux, A. Cortez, O. Sibony, F. Beaufils, V. Modesto, E. Ibiza, A. Abengochea, J. Arago, R. Sanchis, C. Ortola, R. Varas, E. Garcia, S. Kling, R. P. Gie, S. Amantéa, J. Piva, B. Palombini, Santamaría E. Ulloa, Navero J. L. Pérez, Rosa I. de la Ibarra, Hernández M. Espino, Jabalquinto M. J. Velasco, Pérez M. Frías, Rashid Mahmood, Sajid Maqbool, Waqar Hussain, Tariq Mahmood, Fauzia Shoukat, R. Bustos, O. Battisti, J. P. Langhendries, A. Francois, J. M. Bertrand, M. Fedora, R. Nekvasil, V. Vobruba, P. Srnsky, M. Zapadlo, Z. Zivkovic, S. Mihailovic
Journal: Intensive Care Medicine (1996)