tbuckley/cabot-search huggingface dataset:
포스터 전시 : 악성 간종양과 감별이 어려웠던 Sclerosed Hemangioma 1예
Authors: 황준영, 박혜원, 서상혁, 장병국, 박경식, 조광범, 황재석, 안성훈, 박승국, 권중혁, 강구정, 강유나
Journal: Clinical and Molecular Hepatology (2003)

배경/목적: 간의 혈관종은 가장 흔히 발생하는 간의 양성 종양으로 그 중에서도 해면 혈관종이 가장 흔한 조직학적 형태이다. 혈관종은 시간이 지나면서 혈전, 반흔, 그리고 석회화 등을 동반할 수 있으며 드물게는 이러한 과정의 마지막 단계인 섬유화 반흔을 형성하게 되는데 이 상태를 sclerosed hemangioma라고 한다. Sclerosed hemangioma는 간혈관종의 매우 드문 형태로 경화된 작은 혈관들 사이에 많은 양의 콜라겐 조직과 탄성 섬유들로 구성되어 있다. 방사선학적으로 간내 담도암이나 전이성 간암과 유사하므로 감별이 중요하다. 저자들은 간의 악성 종양과 감별이 어렵고 보고가 드문 sclerosed hemangioma 1예를 경험하여 보고하는 바이다. 증례: 48세 여자 환자가 3개월간의 우상복부 불쾌감을 주소로 개인 의원을 방문하여 시행한 복부 초음파와 복부 CT에서 간우엽의 종괴가 발견되어 본원으로 전원되었다. 신체 검사에서 활력 징후는 모두 정상이었다. 진찰 소견에서 간이 늑골연 아래에 10 cm 정도 만져졌으나 압통은 없었고 황달은 관찰되지 않았다. 검사 소견은 백혈구 5880/uL, 혈색소 10.1 gm/dL, 혈소판 304,000/uL이었고, 혈청 생화학 검사에서 ALP 53 IU/L, AST 21 IU/L, ALT 16 IU/L, 총단백 6.9 g/dL, 알부민 4.4 g/dL, 총 빌리루빈 0.6 mg/dL 이었다. HBs Ag 음성, HBs Ab 양성, HBc Ab 양성, HCV Ab 음성이었다. α-FP은 4.71 ng/mL, PIVKA II 4.71 ng/mL, CEA 2.11 ng/mL, CA 19-9는 26.71 U/mL 이었다. 자기공명영상에서 간우엽에 직경이 10 cm인 큰 타원형의 경계가 뚜렷한 종괴가 관찰되었고, 종괴는 T1 강조영상에서 저신호강도를 보이고 T2 강조영상에서 검게 보였으며 조영제 주입후 역동적 MR에서 서서히 결절성으로 지연조영증강되는 것이 관찰되었다. CT 유도하 경피적 간생검에서는 섬유조직만 관찰되었다. 자기공명영상에서 T2 강조영상에 검게 보이며 부분적으로 지연조영증강되므로 악성 간종양을 배제할 수 없었고, 환자가 큰 종괴로 인한 불쾌감을 호소하므로 수술을 시행하였다. 육안적으로 종괴는 고무타이어와 같은 탄성을 가진 흰색의 단단한 종괴였고, 크기는 직경이 9 cm이었다. 조직학적으로는 여러개의 경화된 작은 혈관들 사이로 많은 양의 콜라겐 조직과 섬유화가 관찰되었고, 혈관들은 내강의 허탈이 관찰되었다. 상기환자는 방사선학적 소견과 조직학적 소견으로 sclerosed hemangioma로 진단하였다. 결론: 상기 환자는 자기공명영상에서 부분적으로 지연조영증강되는 소견이 보여 간내 담도암이나 전이성 간암과의 감별이 어려웠다. 간혈관종에서 볼 수 있는 강한 조영증강이 없는 것은 종괴의 대부분을 차지하고 있는 많은 양의 섬유조직 때문으로 생각된다. 저자들은 조직학적으로 확진된 sclerosed hemangioma의 드문 1예를 경험하여 보고하는 바이다.
Bleeding time prolongation with streptokinase and its reduction with 1-desamino-8-D-arginine vasopressin.
Authors: M TJohnstone, TAndrews, J AWare, M ARudd, DGeorge, MWeinstein, JLoscalzo
Journal: Circulation (1990)

The mechanism by which treatment with thrombolytic agents causes bleeding is not known. Recently, frequency of bleeding events has been shown to correlate with bleeding time, particularly in individuals treated with aspirin. We examined the effects of streptokinase (20,000-60,000 IU/kg) on bleeding time in 40 rabbits pretreated with aspirin, a model for fibrinolytic therapy. We then tested the effects of 1-desamino-8-D-arginine vasopressin (DDAVP) (0.3 microgram/kg), an agent known to reduce bleeding time in a variety of bleeding disorders, in 20 rabbits and compared the results with those of a control group of rabbits receiving normal saline placebo. Aspirin increased the bleeding time from a baseline mean +/- SEM value of 119 +/- 15 to 191 +/- 34 seconds in the control group and from 114 +/- 6 to 188 +/- 18 seconds in the experimental group. The addition of streptokinase increased the bleeding time to 592 +/- 119 seconds in the control group and 810 +/- 114 seconds in the experimental group (p = NS). Su...
From the authors
Authors: Y. J. Kim, T. S. Shim
Journal: European Respiratory Journal (2008)

We are grateful to D. Aggarwal and P.R. Mohapatra for their thoughtful comments.

Regarding the importance of the information on anti-tuberculous (TB) medication, D. Aggarwal's opinion is definitely correct. In Korea, a 6-month short course of chemotherapy (with four drugs: isoniazid; rifampicin; ethambutol; and pyrazinamide) was adopted in the mid-1980s in private sector hospitals and in 1990 in healthcare clinics (public sector) 1. Hence, in our study in the present issue …
Role of resistance and exchange vessels in local microvascular control of skeletal muscle oxygenation in the dog.
Authors: H JGranger, A HGoodman, D NGranger
Journal: Circulation Research (1976)

The effects of reduction in perfusion pressure, arterial hypoxia, muscle contraction, and adrenergic stimulation on the hindlimb muscle circulation were studied. Under normal conditions (venous PO2 greater than or equal to 40 mm Hg), oxygen delivery to the muscle was maintained mainly by large increases in the capillary exchange capacity and the oxygen extraction ratio in accord with tissue demand following the application of the above stresses. The participation of the resistance vessels under these conditions was minimal. The prevailing venous oxygen tension then was reduced by several means and the response of vascular resistance and capillary exchange capacity to the same stresses was reexamined. At the lower prevailing venous PO2, the sensitivity of the resistance vessels to metabolic and hemodynamic disturbances was greatly increased. Consequently, blood flow autoregulation, functional hyperemia, and hypoxic hyperemia were more intense when venous oxygen tension was low. In contrast, the contributio...
Appraisal of sinus node artery disease.
Authors: T REngel, S GMeister, G SFeitosa, H AFischer, W SFrankl
Journal: Circulation (1975)

The relationship of depressed sinus node function to coronary artery disease (CAD) was evaluated. The sinus node artery (SNA) was easily identified in all of 80 unselected normal coronary arteriograms. Angiographic disease of, or significant obstruction proximal to, the SNA was seen in 21% of 80 unselected CAD patients. Heart rate and sinoatrial recovery times (SART) were obtained in 50 consecutive unmedicated patients prior to arteriography. There was no difference between the SART of 23 CAD patients free of SNA involvement (1092 msec +/- 55 sem) and 18 normals (1070 +/- 40 msec). Nine patients with SNA involvement had shorter SART (941 +/- 52 MSEC) than normals (P less than 0.05) or other CAD patients (NS). Similar results were obtained for heart rate. No patient with SNA involvement had a prolonged SART or sick sinus syndrom (SSS). six of the 50 patients studied were symptomatic with SSS. Five of these SSS patients had CAD but none had angiographic evidence of SNA involvement. Obstructions involving th...
Comparison of the effects of different inotropic interventions on force, velocity, and power in rabbit myocardium.
Authors: Y CChiu, K RWalley, L EFord
Journal: Circulation Research (1989)

To gain some insight into inotropic mechanisms, we compared the effects of several classes of inotropic interventions on the isometric twitch and force-velocity properties of isolated rabbit myocardium. Postextrasystolic potentiation was chosen as one of the interventions in the belief that its onset is so rapid that it would be unlikely to cause substantial chemical changes in the contractile proteins and that most of the effects would be due to changes in the level of activation. The effects of a digitalis analogue (acetylstrophanthidin), an adrenergic agent (isoproterenol), and a methylxanthine (caffeine) were then compared with those of postextrasystolic potentiation. The conditions were chosen so that each agent caused a twofold increase in twitch force. Acetylstrophanthidin and postextrasystolic potentiation caused twitch force to increase with only a slight (11%) decrease in time to peak force. Isoproterenol caused the peak of the twitch to occur substantially (40%) earlier with marked abbreviation...
Ischemia-reperfusion impairs endothelium-dependent relaxation of coronary microvessels but does not affect large arteries.
Authors: J EQuillen, F WSellke, L ABrooks, D GHarrison
Journal: Circulation (1990)

We examined the effects of ischemia with and without reperfusion on endothelium-dependent and -independent vascular relaxation in both conduit and resistance coronary arteries. Studies were performed on dogs under control conditions (n = 13) or after 1 hour of circumflex coronary artery occlusion with (n = 10) or without (n = 8) 1 hour of reperfusion. Rings of obtuse marginal branches of the left circumflex coronary artery (conduit arteries) were studied in organ chambers. Coronary microvessels (110-220-microns diameter) were studied in a pressurized state with an in vitro microvessel imaging apparatus. Relaxation was evaluated after preconstriction with prostaglandin F2 alpha and U46619 (a thromboxane A2 analogue) in conduit and resistance vessels, respectively. Conduit vessel function was not altered by ischemia with or without reperfusion. Endothelium-dependent microvascular relaxation was depressed in response to acetylcholine, ADP, and calcium ionophore A23187 after ischemia with reperfusion compared...
Alpha-receptor stimulation by endogenous and exogenous norepinephrine and blockade by phentolamine in pial arteries of cats.
Authors: WKuschinsky, MWahl
Journal: Circulation Research (1975)

The question regarding the existence of an alpha-adrenergic component of pial arterial tone was investigated using a microapplication technique combined with the measurement of vascular diameter. Concentration-response curves for the alpha-receptor blocker, phentolamine, revealed no vascular reaction for a concentration range from 2.5 x 10(-11) to 2.5 x 10(-7) M. At higher concentrations (up to 1.3 x 10(-3) M) concentration-dependent dilations were observed. Constrictions of pial arteries induced by perivascular injection of 2.5 x 10(-6) M norepinephrine could be reduced by 38% and 73% when phentolamine was applied simultaneously in concentrations of 2.5 x 10(-7) and 2.5 x 10(-6) M, respectively, whereas constrictions due to 2.5 x 10(-4) M norepinephrine were not reduced by 2.5 x 10(-6) M phentolamine, indicating a competitive antagonism between norepinephrine and phentolamine for pial arteries. Stimulation of the cervical sympathetic chain (90 seconds, 10 v, 1.4 msec, 20 Hz) induced constrictions of pial...
Evidence of genetic heterogeneity in five kindreds with familial hypertrophic cardiomyopathy.
Authors: N DEpstein, LFananapazir, H JLin, JMulvihill, RWhite, J MLalouel, R PLifton, A WNienhuis, MLeppert
Journal: Circulation (1992)

BACKGROUNDRecently, two families with hypertrophic cardiomyopathy have been shown to have mutations in the cardiac beta-myosin heavy chain gene (beta-MHC) located on the long arm of chromosome 14.METHODS AND RESULTSWe have performed linkage analysis of five newly ascertained pedigrees with more than 50 chromosomal markers detecting polymorphisms. Our findings confirm the linkage to beta-MHC gene locus on chromosome 14 in one family (LOD score, 4.50) and suggest linkage to the same gene in another kindred. Chromosome 14 markers were not linked to the disease gene in the other three kindreds, however, and a test for genetic heterogeneity was statistically significant. Moreover, markers for the beta-MHC gene identified affected individuals who were recombinants with respect to this gene and the disease phenotype in these three kindreds.CONCLUSIONSThese results provide conclusive evidence that hypertrophic cardiomyopathy in separate families is caused by mutations in disease genes at two or more locations in ...
Spontaneous sarcoplasmic reticulum calcium release in rat and rabbit cardiac muscle: relation to transient and rested-state twitch tension.
Authors: A AKort, E GLakatta
Journal: Circulation Research (1988)

Scattered light intensity fluctuations (SLIF) (which monitor spontaneous Ca2+ release from the sarcoplasmic reticulum [SR]) and resting and twitch tension were measured during intervals after stimulation in rat and rabbit papillary muscles. For 1 to 5 seconds after stimulation of rat muscle bathed in 1.5 mM [Ca2+] (Cao), twitch and resting tension are depressed and SLIF are transiently abolished. SLIF and resting tension then recover simultaneously and monotonically but lag behind the restitution of twitch tension. In the absence of further stimulation, SLIF persist and the rested state twitch amplitude remains potentiated. When Cao is increased above 2.5 mM, the restitution of all parameters following stimulation is accelerated and becomes oscillatory; the lag of SLIF and resting tension restitution behind that of the twitch increases such that twitch amplitude increases, overshoots, and decreases to a nadir as SLIF and resting tension reach their initial maximum. In a given muscle, the maximum twitch am...
Myocyte mitotic division in the aging mammalian rat heart.
Authors: PAnversa, DFitzpatrick, SArgani, J MCapasso
Journal: Circulation Research (1991)

To determine whether myocyte mitotic division occurs in the adult mammalian heart and whether this cellular process is affected by aging, we measured the percentage of myocyte nuclei showing metaphase chromosomes in myocytes isolated from the left and right ventricles of rats at 8-12, 19-24, and 28-32 months after birth. Metaphase chromosomes were found at all ages in both ventricles. However, from 8-12 to 28-32 months, the fraction of nuclei exhibiting metaphase chromosomes increased 6.3-fold and 2.3-fold in the left and right ventricles, respectively. Thus, myocyte cellular hyperplasia is present in the adult and aging myocardium as a compensatory mechanism to regenerate tissue mass and recover function, which are lost with the progression of life and senescence.
Inhibition of human platelet aggregation and cytoplasmic calcium response by calcium antagonists: studies with aequorin and quin2.
Authors: J AWare, P CJohnson, MSmith, E WSalzman
Journal: Circulation Research (1986)

Calcium antagonists inhibit platelet aggregation, but whether this action is due to inhibition of the effect of agonists on cytoplasmic ionized calcium concentration is unknown. We studied this problem by loading gel-filtered platelets with either quin2 or aequorin and stimulating them with epinephrine, arachidonate, thrombin, the calcium ionophore A23187, 1-oleoyl-2-acetyl glycerol, or adenosine diphosphate in media with or without extracellular calcium. In response to all of these agonists, aequorin indicated an increase in cytoplasmic calcium that accompanied or preceded platelet aggregation. In calcium-containing media, verapamil, nifedipine, and diltiazem inhibited these effects in a concentration-dependent fashion, except for those produced by thrombin and A23187. Removal of extracellular calcium with EGTA reduced the calcium response to arachidonate, adenosine diphosphate, and 1-oleoyl-2-acetyl glycerol, and the calcium response and aggregation were further inhibited by the calcium antagonists. In ...
Respiratory modulation of muscle sympathetic nerve activity in intact and lung denervated humans.
Authors: D RSeals, N OSuwarno, M JJoyner, J GCopeland, J ADempsey
Journal: Circulation Research (1993)

We determined the influences of breathing-induced changes in intrathoracic and intravascular pressures, central respiratory drive, and pulmonary vagal feedback on the within-breath variation in skeletal muscle sympathetic nerve activity (MSNA) in humans. MSNA (peroneal microneurography), arterial blood pressure (Finapres finger monitor), and tidal volume (VT) were recorded continuously in six normal subjects and four heart-lung transplant patients during: 1) spontaneous air breathing; 2) increased FICO2; 3) voluntary augmentation of VT with and without inspiratory resistance; and 4) positive pressure, passive mechanical ventilation. During conditions 3 and 4, which were performed under isocapnic conditions with a high MSNA background (either high resting activity or nonhypotensive lower body suction), subjects breathed at control or elevated VT with normal or prolonged inspiratory time (TI); breathing frequency was 12 breaths per minute. During control breathing in normal subjects there was a distinct wit...
Acute myocarditis. Rapid diagnosis by PCR in children.
Authors: A BMartin, SWebber, F JFricker, RJaffe, GDemmler, DKearney, Y HZhang, JBodurtha, BGelb, JNi
Journal: Circulation (1994)

BACKGROUNDThe diagnosis of viral myocarditis remains difficult and generally depends on clinical and histological criteria. Viral cultures and serology are often unrewarding, with low yields. The purpose of this study was to analyze the usefulness of polymerase chain reaction (PCR) in the rapid diagnosis of acute myocarditis in children.METHODS AND RESULTSPCR was used to analyze 38 myocardial tissue samples from 34 patients with suspected acute viral myocarditis and 17 control patients with congenital heart disease (14) or hypertrophic cardiomyopathy (3). Myocardial samples were obtained at the time of right ventricular biopsy (13 samples), from explanted hearts (18 samples) at transplantation, and from cardiac autopsy specimens (24 samples) and were evaluated for the presence of enterovirus, cytomegalovirus (CMV), adenovirus, and herpes simplex virus (HSV) using PCR primers designed to consensus and unique sequences of these viral genomes. Blood also was obtained at the time of biopsy (11) or transplant ...
Voltage-dependent Ca2+ channels in resistance arteries from spontaneously hypertensive rats.
Authors: YOhya, IAbe, KFujii, YTakata, MFujishima
Journal: Circulation Research (1993)

Alterations in voltage-dependent Ca2+ channels in the arterial smooth muscle cells of spontaneously hypertensive rats (SHR) were investigated using the whole-cell voltage clamp and compared with Wistar-Kyoto (WKY) rats. Single cells were freshly isolated from resistance mesenteric arteries from 4- to 5-week-old (young) and 16- to 18-week-old (adult) SHR. Elevated blood pressure was only evident in adult SHR, not in young SHR. In young rats, the Ca2+ channel current density (current amplitude normalized by cell capacitance) was significantly higher (P < .01) in SHR than in WKY rats at the command potential of -10 mV or higher (with 50 mmol/L Ba2+): The current density at 20 mV was -16.8 +/- 1.1 pA/pF in SHR (n = 38 cells) and -11.0 +/- 0.8 pA/pF in WKY rats (n = 30 cells). In adult rats, the difference in current densities disappeared: -15.9 +/- 1.3 pA/pF in SHR (n = 25 cells) and -15.6 +/- 1.5 pA/pF in WKY rats (n = 29 cells). The ratio of maximal amplitude of T-type current to that of L-type current was ...
Venous and arterial endothelia: different dilator abilities in dog vessels.
Authors: C LSeidel, JLaRochelle
Journal: Circulation Research (1987)

It has been demonstrated by other investigators that endothelium-dependent vasodilators are more effective on arterial tissue than on venous tissue. The purpose of this study was to determine if this was due to a difference in the sensitivity of arterial and venous smooth muscle to the endothelial dilator (EDRF) or to a difference in the ability of arterial and venous endothelia to release EDRF. To differentiate between these two possibilities, an in vitro sandwich preparation was used in which the mechanical response to endothelium-dependent dilators of a de-endothelialized vessel was determined when sandwiched with an endothelialized vessel. Using dog femoral artery and saphenous vein, it was determined that acetylcholine (ACh), the ionophore A23187, and thrombin were endothelium-dependent dilators of the femoral artery, but their dilatory ability was significantly less in the saphenous vein. However, if the de-endothelialized saphenous vein was sandwiched with an endothelialized femoral artery, b...
Noninvasive assessment of cardiac function and ventricular dyssynergy by precordial Q wave mapping in anterior myocardial infarction.
Authors: N AAwan, R RMiller, ZVera, D AJanzen, E AAmsterdam, D TMason
Journal: Circulation (1977)

To determine whether multiple lead precordial electrocardiographic recordings offer an improved index for noninvasive estimation of left ventricular hemodynamic function and segmental dyssynergy, precordial mapping was performed in patients with anterior myocardial infarction, and the number of pathologic Q waves (greater than or equal to 0.04 sec) was counted (Q-Index). Left ventricular function was determined by cardiac catheterization and angiography and correlated with the Q-Index. The Q-Index correlated well with dyssynergy extent (r = 0.84) and inversely with ejection fraction (r= -0.87), stroke work index (r = -0.79) and cardiac index (r = =0.66). Three patient groups were defined by Q-Index; group I, 0.04 sec Q complexes less than 15; group II, 15-25; group III, 26-35. Q-Index related closely to functional classification and survival (mean follow-up 12.2 months): group I, 91%; group II, 81%; group III, 40%. Thus 35-lead precordial Q wave mapping with determination of total number of pathologic Q w...
Oral contraceptive treatment decreases arterial low density lipoprotein degradation in female cynomolgus monkeys.
Authors: J DWagner, M RAdams, D CSchwenke, T BClarkson
Journal: Circulation Research (1993)

The effect of oral contraceptive therapy on early events in atherogenesis was studied in female cynomolgus monkeys. After a 1-month dietary challenge, monkeys were randomized into three groups stratified by total plasma cholesterol and high density lipoprotein cholesterol concentrations. The monkeys were then fed a cholesterol-containing diet for 16 weeks. This relatively short period ensured that studies were done before any treatment-induced differences in arterial morphology occurred. Monkeys were treated with either diet alone (control group), with the addition of a monophasic oral contraceptive (equivalent to a human dose of 50 micrograms ethinyl estradiol and 500 micrograms norgestrel per day), or with a triphasic oral contraceptive (equivalent to a human dose of 30-40 micrograms ethinyl estradiol and 50-125 micrograms levonorgestrel per day). Twenty-four hours before necropsy, low density lipoproteins (LDLs) labeled with 131I and LDLs labeled with the residualizing label 125I-tyramine cellobiose we...
THE AMERICAN COLLEGE OF PHYSICIANS AND THE INTERNIST OF THE FUTURE
Authors: M C PINCOFFS
Journal: Annals of Internal Medicine (1952)

Article1 August 1952THE AMERICAN COLLEGE OF PHYSICIANS AND THE INTERNIST OF THE FUTUREMAURICE C. PINCOFFS, M.A.C.P.MAURICE C. PINCOFFS, M.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-37-2-253 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe President's Convocational Address offers an opportunity to one who has been honored by this office to express his conception of the significance of the past history of the College and to formulate his opinions as to the problems that must be met in the future.The chief purpose of the College has been and is to improve constantly the practice of internal medicine. It has exerted a powerful influence in bringing about such improvements as have already occurred.This influence of the College has been exerted in two ways. By far the most important of these, in my opinion,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Presidential Address, Thirty-third Annual Session, American College of Physicians, Cleveland, Ohio, April 23, 1952. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1952Volume 37, Issue 2Page: 253-260KeywordsForecasting ePublished: 1 December 2008 Issue Published: 1 August 1952 Copyright & PermissionsCopyright, 1952, by The American College of PhysiciansPDF downloadLoading ...
Association between rheology and components of lipoproteins in human blood. Results from the MONICA project.
Authors: WKoenig, MSund, EErnst, WMraz, VHombach, UKeil
Journal: Circulation (1992)

BACKGROUNDRecent studies have suggested that several hemostatic factors, leukocyte count, and plasma viscosity are predictive of coronary heart disease. Detailed analyses on lifestyle correlates, in particular plasma lipids and lipoproteins, of determinants of blood rheology have not been reported from epidemiological studies.METHODS AND RESULTSWe studied the relation between determinants of blood rheology and components of lipoproteins in a large sample of a population aged 25-64 years. The rheological parameters investigated were plasma viscosity, hemoglobin, and total serum protein; the lipoprotein variables included total cholesterol, high density lipoprotein (HDL) cholesterol, and the apoproteins A-I, A-II, and B. Covariables considered for possible confounding effects were age, body mass index, smoking behavior, alcohol consumption, and hypertension. Plasma viscosity was found to have a positive linear association with total cholesterol and apoprotein B (partial correlations after adjustment for all...