tbuckley/cabot-search huggingface dataset:
The dilating effect of histamine on pial arteries of cats and its mediation by H2 receptors.
Authors: MWahl, WKuschinsky
Journal: Circulation Research (1979)

We studied the effect of histamine and H1 or H2 blockers on the diameter of pial arteries (39-227 micron) using microapplication into the perivascular space. Concentration-response curves for histamine showed dilations which started at 10(-7) M and were maximal at 10(-5) and 10(-4) M. The H2 blocker, cimetidine, induced no vascular reaction over the whole concentration range tested (10(-7) to 10(-3) M). The H1 blocker, mepyramine, was not vasoactive in the concentration range from 10(-7) to 5 X 10(-5) M and evoked dilations at higher concentrations. The concentration-response curve for histamine was only slightly displaced by 10(-5) M mepyramine but was significantly shifted to the right by 10(-5) M cimetidine. The dilating effect of histamine could be reduced in a stepwise manner by increasing concentrations of cimetidine. These findings are in accordance with a selective antagonism between histamine and cimetidine at the H2 receptors of smooth muscle cells of pial arteries. The insignificant role of H1 ...
Alterations in the Epigenetic Network Controlling Transcription Activity, Chromatin Structure and Region-Specific Repair of Different Genomic Loci Predicts Clinical Outcome in Multiple Myeloma.
Authors: Hara G. Episkopou, Soterios A. Kyrtopoulos, Petros P. Sfikakis, Maria Fousteri, Evangelos Terpos, Leon H. Mullenders, Vassilis L. Souliotis, Meletios A. Dimopoulos
Journal: Blood (2009)
Pathology of stable and unstable angina pectoris.
Authors: R BGuthrie, ZVlodaver, D MNicoloff, J EEdwards
Journal: Circulation (1975)

The clinical and pathological data from 46 patients who died during or shortly after coronary bypass surgery and one patient who died shortly after angiography were studied. Each patient was placed into one of three clinical categories of angina pectoris. Twelve were classified as having unstable angina pectoris, 20 as stable severe angina, and 15 as stable moderate angina. No significant difference was found between the three catagories whem age, sex, presence of hypertension, lipid abnormalities, diabetes, smoking, family history of myocardial infarction, or history of previous mycardial infarction were examined. Most patients in all classes of angina had extensive atherosclerotic coronary disease: 12 patients had triple vessel plus left main disease; 25, triple vessel disease; nine double vessel disease; and only one, single vessel disease. There was no difference in severity or distribution of coronary disease when the three catagories of angina were compared. Thirty-six of the 47 patients had evidenc...
The <i>Let-7</i> Chronoregulatory Cascade Components May Act Independently to Regulate Fetal Hemoglobin in Human Adult Erythroblasts
Authors: Jaira F. de Vasconcellos, Colleen Byrnes, Y. Terry Lee, May Li, Antoinette Rabel, Richard L. Proia, Jeffery L. Miller
Journal: Blood (2017)
Tolerance of the hypertrophic heart to ischemia. Studies in compensated and failing dog hearts with pressure overload hypertrophy.
Authors: W HGaasch, M RZile, P KHoshino, E OWeinberg, D RRhodes, C SApstein
Journal: Circulation (1990)

Tolerance of the canine heart to prolonged ischemic arrest was studied in 10 hearts from normal control dogs and 15 hearts from dogs with left ventricular hypertrophy (LVH); experiments were performed 1 year after banding the aorta in 8-week-old puppies. At 1 year, hemodynamic studies revealed decreased left ventricular (LV) fiber shortening and elevated end-diastolic pressure (EDP) in five dogs (group with LVH failure); 10 dogs exhibited normal shortening and normal EDP (group with LVH compensation). The left ventricle-to-body weight ratio (g/kg) was 4.4 +/- 0.8 in the control group of dogs, 7.7 +/- 1.0 in the group with LVH compensation, and 10 +/- 2.5 in the group with LVH failure. The tolerance to 60 minutes of global ischemia (37 degrees C) followed by 90 minutes of reperfusion was studied in an isolated blood-perfused heart apparatus (isovolumic left ventricle, coronary perfusion pressure of 100 mm Hg). In the baseline (preischemic) state, coronary blood flow, myocardial oxygen consumption, lactate ...
The Pharmacokinetics (PK) of GBT440 Following Single Doses in Pediatric Patients with Sickle Cell Disease (SCD)
Authors: Carla B Washington, Michelle Green, Adlette C. Inati, Clark Brown, Carolyn C Hoppe, Winfred Wang, Ganesh Balaratnam, Sandra Dixon, Erica Fong, Athiwat Hutchaleelaha, Margaret E Tonda, Josh Lehrer
Journal: Blood (2017)
Reduced suppressor cell activity in congestive cardiomyopathy and in myocarditis.
Authors: REckstein, WMempel, H DBolte
Journal: Circulation (1982)

We studied suppressor cell function in 10 patients who had congestive cardiomyopathy, 13 patients who had myocarditis and 98 healthy controls. Myocardial biopsy, coronary arteriography and left ventricular angiography were used to define and differentiate congestive cardiomyopathy and myocarditis. The suppressor component of the immune response was assessed by examining the in vitro responses of peripheral blood lymphoid (PBL) cells under standard conditions. Briefly, PBL cells were incubated with concanavalin A to stimulate suppressor activity. Induced activity was measured by the ability of PBL cells to inhibit 3H-thymidine uptake of nonstimulated autologous cells when subsequently presented with allogenic or mitogenic stimuli.
Coronary artery disease in African-Americans.
Authors: C LCurry
Journal: Circulation (1991)

Contrary to opinions generally accepted in the past, CHD is very common in both African-American men and women, with incidence rates approaching those of US Caucasians. Higher prevalence of hypertension, diabetes, cigarette smoking, and obesity all contribute to the high level of CHD in African-Americans. Additional research is needed about the interrelations and management of various risk factors for CHD in African-Americans outside of the sudden death of African-Americans outside of the hospital is urgent, and special attention should be given to accessibility and use of health services by minority populations.
Avelumab plus standard-of-care chemoradiotherapy versus chemoradiotherapy alone in patients with locally advanced squamous cell carcinoma of the head and neck: a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial
Authors: Nancy Y Lee, Robert L Ferris, Amanda Psyrri, Robert I Haddad, Makoto Tahara, Jean Bourhis, Kevin Harrington, Peter Mu-Hsin Chang, Jin-Ching Lin, Mohammad Abdul Razaq, Maria Margarida Teixeira, József Lövey, Jerome Chamois, Antonio Rueda, Chaosu Hu, Lara A Dunn, Mikhail Vladimirovich Dvorkin, Steven De Beukelaer, Dmitri Pavlov, Holger Thurm, Ezra Cohen
Journal: The Lancet Oncology (2021)
Abstract 8952: ST-Segment Depression in Lead aVR Predicts In-Hospital Adverse Outcomes in Patients With Inferior Wall Acute Myocardial Infarction
Authors: Masami Kosuge, Toshiaki Ebina, Kiyoshi Hibi, Noriaki Iwahashi, Kengo Tsukahara, Nobuhiko Maejima, Mitsuaki Endo, Satoshi Morita, Satoshi Umemura, Kazuo Kimura
Journal: Circulation (2012)

Introduction: During inferior wall acute myocardial infarction (IWMI), lead aVR is frequently ignored. However, ST-segment depression in lead aVR (ST↓aVR) during IWMI might represent a reciprocal change in response to an opposite vector resulting from ST-segment elevation in the apical region, suggesting a larger area at risk. Hypothesis: We assessed the hypothesis that ST↓aVR can provide important prognostic information in patients with reperfused IWMI. Methods: We studied 268 patients with a first IWMI who had TIMI 3 flow of the right coronary artery or left circumflex coronary artery after fibrinolysis or primary percutaneous coronary intervention within 6 h after symptom onset. Patients were divided into the 3 groups according to the degree of ST↓aVR on admission ECG: G-A, 122 patients with no ST↓aVR; G-B, 95 patients with ST↓aVR ≤1.0 mm; and G-C, 51 patients with ST↓aVR &gt;1.0 mm. The perfusion territory of the culprit artery was assessed on the basis of the angiographic distribution score. Impaired myocardial reperfusion was defined as myocardial blush grade 0/1 on the final angiogram. Results: There were no differences in age, coronary risk factors, time to admission, reperfusion therapy, culprit artery, or final TIMI flow grade among the 3 groups. In G-A, G-B, and G-C, the sum of ST-segment elevation in leads II, III, aVF and V5-6 on admission ECG was 4±4, 9±5, and 17±7 mm (p&lt;0.01); the angiographic distribution score was 0.5±0.2, 0.6±0.2, and 0.7±0.1 (p&lt;0.01); peak creatine kinase level was 2225±1515, 3150±1792, and 4911±2238 mU/ml (p&lt;0.01); and the frequencies of impaired myocardial reperfusion was 4%, 18%, and 71% (p&lt;0.01); the combined outcome of in-hospital death, reinfarction, or congestive heart failure was 2%, 7%, and 14% (p&lt;0.01), respectively. Multivariate analysis showed that as compared with no ST↓aVR, the odds ratios (95% CI) for in-hospital adverse events associated with ST↓aVR ≤1.0 mm and ST↓aVR &gt;1.0 mm were 1.49 (0.64-3.39; p=0.15) and 2.01 (1.18-4.51; p&lt;0.05), respectively. Conclusions: In patients with reperfused IWMI, greater ST↓aVR on admission ECG is associated with a larger area at risk, impaired myocardial reperfusion, and a larger infarct size. ST↓aVR &gt;1.0 mm is an independent predictor of in-hospital adverse outcomes.
Comparison of thallium-201 scanning in idiopathic dilated cardiomyopathy and severe coronary artery disease.
Authors: R FDunn, R FUren, NSadick, GBautovich, AMcLaughlin, MHiroe, D TKelly
Journal: Circulation (1982)

To determine whether cardiomyopathy could be distinguished from coronary artery disease, we used thallium scanning to study 25 patients with severe left ventricular dysfunction and chronic heart failure. Ten patients had normal coronary arteries and idiopathic cardiomyopathy (ejection fraction 20 +/- 5%), and 15 patients had multivessel coronary disease and left ventricular dysfunction (ejection fraction 25 +/- 6%). The exercise time and maximal heart rate were similar in the two groups. Two patients with cardiomyopathy and 11 with coronary artery disease had a positive exercise ECG (p less than 0.05). Thallium scans showed perfusion defects in all 25 patients. The perfusion defects were complete in nine coronary artery disease patients (60%) and in one patient (10%) with cardiomyopathy (p less than 0.05). Extensive defects involving more than 40% of the left ventricular circumference, the number of segments involved, redistribution on the 4-hour scan, lung uptake and ventricular size were similar in the ...
Tumor Cellularity and Infiltrating Lymphocytes as a Survival Surrogate in HER2-Positive Breast Cancer
Authors: Nuria Chic, Stephen J Luen, Paolo Nuciforo, Roberto Salgado, Debora Fumagalli, Florentine Hilbers, Yingbo Wang, Evandro de Azambuja, István Láng, Serena Di Cosimo, Cristina Saura, Jens Huober, Aleix Prat, Sherene Loi
Journal: JNCI Journal of the National Cancer Institute (2021)

In early-stage HER2-positive breast cancer, biomarkers that guide deescalation and/or escalation of systemic therapy are needed. CelTIL score is a novel, combined biomarker based on stromal tumor-infiltrating lymphocytes and tumor cellularity and is determined in tumor biopsies at week 2 of anti-HER2 therapy only. We evaluated the prognostic value of CelTIL in 196 patients with early-stage HER2-positive disease treated with standard trastuzumab-based chemotherapy in the NeoALTTO phase III trial. Using a prespecified CelTIL cutoff, a better 5-year event-free survival and overall survival was observed between CelTIL-high and CelTIL-low score with a 76.4% (95% confidence interval [CI] = 68.0% to 85.0%) vs 59.7% (95% CI = 50.0% to 72.0%) (hazard ratio = 0.40, 95% CI = 0.17 to 0.94) and 86.4% (95% CI = 80.0% to 94.0%) vs 73.5% (95% CI = 64.0% to 84.0%) (hazard ratio = 0.43, 95% CI = 0.20 to 0.92), respectively. Statistical significance was maintained after adjusting for baseline tumor-infiltrating lymphocytes, hormone receptor status, pretreatment tumor size and nodal status, type of surgery, treatment arm, and pathological complete response. Further studies to support CelTIL as an early readout biomarker to help deescalate or escalate systemic therapy in HER2-positive breast cancer seem warranted.
Digitalis-associated cardiac mortality after myocardial infarction.
Authors: A JMoss, H TDavis, D LConard, J JDeCamilla, C LOdoroff
Journal: Circulation (1981)

The effect of digitalis therapy on 4-month posthospital cardiac mortality was investigated in 812 patients who survived the hospital phase of acute myocardial infraction. A stepwise multiple logistic regression analysis was used to identify variables associated with increased mortality and to adjust for differences in confounding variables between digitalis and nondigitalis patients. The major 4-month mortality (10 of 26 patients [38.5%]) occurred in digitalis-treated patients with congestive heart failure in the coronary care unit and complex ventricular premature depolarizations (VPDs) on the predischarge Holter recording. Logistic analyses that controlled for confounding variables indicated that digitalis use contributed to the increased mortality rate in this high-risk subset. The predicted mortality difference due to digitalis in patients with congestive heart failure and complex VPDs, adjusted for relevant nondigitalis risk factor variables, was 30% (90% confidence interval 18-42%). This retrospecti...
Immediate versus deferred beta-blockade following thrombolytic therapy in patients with acute myocardial infarction. Results of the Thrombolysis in Myocardial Infarction (TIMI) II-B Study.
Authors: RRoberts, W JRogers, H SMueller, C TLambrew, D JDiver, H CSmith, J TWillerson, G LKnatterud, SForman, EPassamani
Journal: Circulation (1991)

In the Thrombolysis in Myocardial Infarction (TIMI) Phase II trial, patients received intravenous recombinant tissue-type plasminogen activator (rt-PA) and were randomized to either a conservative or an invasive strategy. Within this study, the effects of immediate versus deferred beta-blocker therapy were also assessed in patients eligible for beta-blocker therapy, a group of 1,434 patients of which 720 were randomized to the immediate intravenous group and 714 to the deferred group. In the immediate intravenous group, within 2 hours of initiating rt-PA metoprolol was given (5 mg intravenously at 2-minute intervals over 6 minutes, for a total intravenous dose of 15 mg, followed by 50 mg orally every 12 hours in the first 24 hours and 100 mg orally every 12 hours thereafter). The patients assigned to the deferred group received metoprolol, 50 mg orally twice on day 6, followed by 100 mg orally twice a day thereafter. The therapy was tolerated well in both groups and the primary end point, resting global e...
Influence of secobarbital and alpha-chloralose, and of vagal and sympathetic interruption, on left ventricular activation after acute coronary artery occlusion in the dog.
Authors: RRuffy, D ELovelace, S BKnoebel, D PZipes
Journal: Circulation Research (1981)

The purpose of this study was to examine the effect of secobarbital vs. alpha-chloralose anesthesia, and of tonic autonomic influence, upon ischemia-induced subepicardial and subendocardial bipolar electrogram changes during acute coronary artery occlusion in the open-chest dog. We found that the degree of bipolar electrogram alterations for similar reductions of regional myocardial blood flow was less in dogs anesthetized with alpha-chloralose than in those anesthetized with secobarbital. We also noted greater electrogram change when the sympathetic system was unopposed by the vagus nerves. Finally, this study demonstrates the reproducibility of ischemia-induced changes in bipolar electrograms during serial, short term, acute coronary artery occlusions.
Instantaneous blood flow responses to positive end-expiratory pressure with spontaneous ventilation.
Authors: R APerschau, C JPepine, W WNichols, J BDowns
Journal: Circulation (1979)

Variable hemodynamic responses to positive end-expiratory pressure (PEEP) with spontaneous ventilation have been reported. To clarify these responses, 15 awake patients were studied using a catheter-tip velocity transducer to record phasic aortic root blood flow continuously before, during and after PEEP (10 cm H2O) applied with a face mask. Central blood volume and effective ventricular filling pressures were measured. Phasic pulmonary artery blood flow was also simultaneously recorded in three of these patients. PEEP produced an acute aortic blood flow reduction, detected within one respiratory cycle. Stroke volume decreased 12%, and since heart rate was unchanged, cardiac output also declined (p less than 0.05). Inspiratory-to-expiratory aortic flow changes were less during PEEP. In contrast, inspiratory-to-expiratory pulmonary artery flow alterations were exaggerated due to a marked flow decline during expiration. Central blood volume and effective left ventricular filling pressure decreased 9% and 19...
Primary role of renal homografts in setting chronic blood pressure levels in rats.
Authors: L KDahl, MHeine
Journal: Circulation Research (1975)

The genotype of homograft kidneys plays the primary role in determining chronic blood pressure levels in two strains of rats with opposite genetically controlled propensities for hyptertension. In hypertensive rats from the hypertension-prone (S) strain, a renal homograft from the same strain resulted in a slight rise in blood pressure to a level that was equivalent to that in appropriate uninephrectomized S controls. In contrast, a renal homograft from the hypertension-resistant (R) strain led to a sharp fall in blood pressure in hypertensive S recipients. Opposite results were found when the host came from the R strain: R homografts maintained the same low pressure as that seen in controls, whereas S homografts resulted in hypertension. We concluded that genetically controlled factors operating through the kidney can chronically modify the blood pressure up or down. The central role of the kidney in hypertension is thus further documented.
New Endoscopic Classification of Gastric Antral Vascular Ectasia by Narrow Spectrum Technology in Patients with Liver Cirrhosis
Authors: RS Abd Elmoneim, A Abd Elmoety, P Salem, N Baddour, M Metawea
Journal: Endoscopy (2021)

Aims: Aim of our study was to assess the efficacy of narrow band technology in comparison to histopathology in diagnosis and classification of GAVE.
Abnormalities of renal perfusion and the renal pressor system in dogs with chronic aortic coarctation.
Authors: S PBagby, W JMcDonald, D WStrong, G APorter, W MBennett, L IBonchek
Journal: Circulation Research (1975)

To clarify the role of the renin-angiotensin system in coarctation hypertension, 2-year-old inbred dogs with chronic neonatally induced thoracic aortic coarctation were subjected to 6 days of rigorous salt restriction. The following parameters were then measured: glomerular filtration rate, renal plasma flow, plasma renin activity, plasma renin concentration, renin reactivity, and renin substrate concentration. Glomerular filtration rate and renal plasma flow were significantly lower in salt-restricted coarcted dogs: 3.0 +/- 0.2 and 9.0 +/- 1.5 ml/min kg-1, respectively, compared with values of 4.0 +/- 0.2 (P less than 0.005) and 13.2 +/- 0.6 (P less than 0.025) ml/min kg-1 in salt-restricted controls. Plasma renin activity was abnormally high in experimental dogs: 13.5 +/- 2.5 vs. 4.5 +/- 1.5 ng angiotensin I/ml hour-1 in controls (P less than 0.005). In addition, a significant elevation of renin reactivity (indicating a relative increase in circulating accelerators or a relative decrease in inhibitors o...
Circadian variations in ischemic threshold and their relation to the occurrence of ischemic episodes.
Authors: JBenhorin, SBanai, MMoriel, AGavish, AKeren, SStern, DTzivoni
Journal: Circulation (1993)

BACKGROUNDThe occurrence of ischemic episodes during daily activity has been reported to exhibit a bimodal circadian distribution, yet its relation to the ischemic threshold (heart rate at 1-mm ST segment depression) has not been explored.METHODS AND RESULTSTo determine whether the ischemic threshold during daily activity exhibits a circadian pattern that might relate to the frequency of occurrence of ischemic episodes, we studied the time of occurrence and the heart rate at onset of ischemia in 1,371 ischemic episodes recorded in 41 patients with stable coronary disease, positive exercise testing, and repeated ischemic episodes during ambulatory ECG monitoring (AEM). All patients had 7 days of AEM; 23 were off any anti-ischemic therapy, while 18 were on low dose of beta-blockers. The occurrence of ischemic episodes exhibited the typical bimodal circadian distribution with a prominent peak between 7:00 and 11:00 AM and a second less prominent peak between 6:00 and 9:00 PM. The threshold of myocardial isch...
Lipoprotein(a) in restenosis after percutaneous transluminal coronary angioplasty and coronary artery disease.
Authors: TCooke, RSheahan, DFoley, MReilly, GD'Arcy, WJauch, MGibney, GGearty, PCrean, MWalsh
Journal: Circulation (1994)

BACKGROUNDThe purpose of the study was to investigate the relation of lipoprotein(a) and serum lipid parameters to restenosis after percutaneous transluminal coronary angioplasty (PTCA) and to assess the association of these same biochemical markers to coronary artery disease (CAD) in individuals with angiographically defined normal and diseased coronary arteries.METHODS AND RESULTSSixty-two patients with successful PTCA had follow-up angiography at 35 +/- 10 weeks. Restenosis occurred in 21 male patients (46%) and 6 female patients (38%). Elevated apolipoprotein B (P < .01) and decreased high-density lipoprotein-2 cholesterol (P < .02) were found to be independently associated with restenosis after angioplasty, whereas lipoprotein(a) was not. Eighty-five patients undergoing PTCA were compared with 46 subjects who had no evidence of CAD on angiography. Elevated lipoprotein(a) (P < .001) and reduced apolipoprotein A1 to B ratio (P < .001) were found to be strong independent risk factors for the presence of...
Selective accumulation of the first component of complement and leukocytes in ischemic canine heart muscle. A possible initiator of an extra myocardial mechanism of ischemic injury.
Authors: R DRossen, J LSwain, L HMichael, SWeakley, EGiannini, M LEntman
Journal: Circulation Research (1985)

Myocardial concentrations of C1q, a subunit of the first component of complement, were measured 5-120 minutes after ligation of a coronary artery in dogs injected with 125I-labeled human C1q and 131I-labeled human albumin. The 131I-labeled human serum albumin was used as a plasma protein marker. Ischemic regions of myocardium were defined by measuring regional myocardial blood flow by the reference sample method at intervals after coronary artery occlusion. Significant accumulations of 125I-C1q were demonstrated in the ischemic myocardium after coronary artery occlusions lasting 45 minutes. Some localization of C1q in ischemic myocardium was observed after a 15-minute occlusion, but the accumulations of C1q achieved in this case were not statistically significant. After coronary artery occlusions lasting greater than or equal to 45 minutes, left ventricular concentrations of C1q correlated reciprocally with regional myocardial blood flow. Moreover, high concentrations of C1q persisted in formerly ischemic...