tbuckley/cabot-search huggingface dataset:
Hormone interactions in the isolated rabbit heart. Synthesis and coronary vasomotor effects of prostaglandins, angiotensin, and bradykinin.
Authors: PNeedleman, G RMarshall, B ESobel
Journal: Circulation Research (1975)

In the present study, the synthesis and degradation of several potent vasoactive substances influencing coronary resistance were characterized in the isolated perfused rabbit heart. Prostaglandin synthetase activity, angiotensin converting enzyme activity, and bradykininase activity (without angiotensinase) were observed. A prostaglandin E2-like substance appeared to be the ednogenous mediator of the coronary vasodilation produced by bradykinin and angiotensin II (AII). (1) The concentration of this prostaglandinlike substance in the coronary venous effluent was directly proportional to the concentration of the coronary vasocilator stimulus (bradykinin or AII). (2) The prostaglandinlike substance released and the coronary dilation produced by the agonists correlated temporally and quantitatively. (3). Abolition of cardiac biosynthesis of the prostaglandinlike substance by indomethacin also abolished the decrease in coronary resistance produced by the agonists. AII, the most potent naturally occurring vaso...
May 2021: Heterogeneity in reported skin manifestations of COVID-19 and vaccines
Authors: Jonathan Kantor
Journal: Journal of the American Academy of Dermatology (2021)

In their important study on skin findings associated with SARS-CoV-2 infection, Tan et al1Tan S.W. Tam Y.C. Oh C.C. Skin manifestations of COVID-19: a worldwide review.JAAD Int. 2021; 2: 119-133Abstract Full Text Full Text PDF PubMed Scopus (86) Google Scholar performed a review of all published articles regarding skin manifestations associated with COVID-19 and evaluated them through a global lens. By casting a broad net and including the full array of published articles from around the world, the authors were able to explore the ways in which the reporting of COVID-19 skin findings varies geographically. Notably, they pointed out the discordance between morphological reports among countries. Some of these were unsurprising—pernio, a condition in which immunoglobulin A immunoreactivity may be modulated by temperature, was reported only rarely in Asia—however, many others remain to be better understood. Most importantly, it is not clear whether differences in the reported skin manifestations truly reflect differences in skin manifestations or whether we are simply seeing artifacts associated with differential reporting practices. It is critical to appreciate that essentially all reports on skin findings associated with COVID-19 are biased; even the best and largest registry studies, such as those sponsored by the American Academy of Dermatology and the International League of Dermatological Societies,2Freeman E.E. McMahon D.E. Lipoff J.B. et al.The spectrum of COVID-19-associated dermatologic manifestations: an international registry of 716 patients from 31 countries.J Am Acad Dermatol. 2020; 83: 1118-1129Abstract Full Text Full Text PDF PubMed Scopus (269) Google Scholar,3McMahon D.E. Gallman A.E. Hruza G.J. et al.Long COVID in the skin: a registry analysis of COVID-19 dermatological duration.Lancet Infect Dis. 2021; 21: 313-314Abstract Full Text Full Text PDF PubMed Scopus (88) Google Scholar are subject to the vagaries of the whims of those choosing to report their data. As we continue to explore the skin manifestations due to vaccination, many questions persist. Despite the murkiness of the data, one thing remains clear—we need dermatologists to continue to engage in prosocial actions, such as registry reporting, to ensure that we have the highest quality data available for hypothesis generation and further research. None disclosed.
Quantification of absolute luminal diameter by computer-analyzed digital subtraction angiography: an assessment in human coronary arteries.
Authors: M CRosenberg, L WKlein, J BAgarwal, GStets, G AHermann, R HHelfant
Journal: Circulation (1988)

Determination of absolute lumen diameters has been shown to be useful in predicting the functional importance of a coronary stenosis. In this study, both single-plane and orthogonal biplane digital subtraction angiograms were obtained in human cadaver coronary arteries. A single absolute diameter was calculated at the site of greatest narrowing in 20 segments by two automated computerized algorithms. Minimum and maximum diameters at the site of the stenosis were measured from pathologic sections prepared after pressure fixation. Method 1, which determines the edges by means of the first derivative of the videodensity curve, derived absolute diameters that fell between the pathologic minimum and maximum in 10 of 20 segments. Method 2, which determines the edges by an average of the first and second derivatives of the videodensity change, derived absolute diameters that fell between the pathologic minimum and maximum diameters in 15 of 20 segments. Method 1 correlated well with the maximum pathologic diamet...
Inhaled corticosteroids downregulate SARS-CoV-2-related genes in COPD: results from a randomised controlled trial
Authors: Stephen Milne, Xuan Li, Chen Xi Yang, Fernando Sergio Leitao Filho, Ana I. Hernández Cordero, Cheng Wei Tony Yang, Tawimas Shaipanich, Stephan F. van Eeden, Janice M. Leung, Stephen Lam, Don D. Sin
Journal: European Respiratory Journal (2021)

<b>In a RCT of 63 patients with COPD, 12 weeks of ICS/LABA therapy downregulated bronchial epithelial expression of the SARS-CoV-2-related genes <i>ACE2</i> and <i>ADAM17</i> compared to LABA alone. This may have implications for COVID-19 susceptibility/severity in COPD.</b>https://bit.ly/3vZnBVO
Abnormal left ventricular wall motion at mid-ejection in patients with coronary heart disease.
Authors: R FLeighton, M EPollack, T GWelch
Journal: Circulation (1975)

The degree of inward motion at mid-ejection was examined for seven segments on the silhouettes of left ventriculograms taken in the 30 degrees RAO projection in patients with normal coronary arteries. The pattern of wall motion described in these patients was used to distinguish abnormalities in mid-systolic wall motion. One or more abnormally contracting segments were found at mid-ejection of 27 of 42 patients with obstructive coronary artery disease and normal end-systolic wall motion. Of the 57 segments found in these patients, 41 or 72% corresponded to sites of significant coronary artery obstruction. Seven patients had electrocardiographic evidence of prior infarction. Following coronary graft surgery in eight patients improved motion was found in association with graft patency in seven priviously delayed segments and two new areas of delayed wall motion associated with nonpatent grafts and electrocardiographic changes of infarction appeared. We postulate that some of the myocardial fibers in late co...
Pathophysiological insights into the cardiomyopathy of Chagas' disease.
Authors: S AMorris, H BTanowitz, MWittner, J PBilezikian
Journal: Circulation (1990)

The evidence gained from both human and animal studies of chronic chagasic cardiomyopathy suggests that the disease occurs as a consequence of several discrete and progressive pathophysiological processes occurring after infection, the ultimate expression of which depends on a host of unidentified factors. Collectively, the infection-associated events compromise microvasculature function and result in hypoperfusion, with consequences indistinguishable from those observed in other, nonparasitological cardiomyopathic diseases secondary to hypoperfusion. Therefore, chronic chagasic cardiomyopathy may share similar pathophysiological abnormalities with other chronic congestive cardiomyopathic states.
Rubin's Pathology: Clinicopathologic Foundations of Medicine
Authors: S. A. Hoda
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Association of a Genetic Risk Score With Body Mass Index
Authors: Hexuan Liu, Guang Guo
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Multicenter Randomized Controlled Trial Of Methods For Removing Polyps Of The Colon Up To 10 MM
Authors: T Nikolaychyk
Journal: Endoscopy (2021)

Methods In November 2018 - November 2020, in 2348 patients (m – 893 (38 %), f - 1455 (61 %), in 1643 (70 %) middle and elderly) 2348 colonoscopies were performed. In 1567 (66.7 %) patients, polyps up to10 mm in size were detected, in most cases, polyps of 6-10 mm were found - 987 (63 %). The morphology of polyps was of flat-elevated - 908 (58 %), the predominant surface pattern was type II (S. Kudo), in 1222 (78 %) cases, by NICE type 2 - 1144 (73 %), according to the vascular pattern, type I prevailed (Y. Sano) - 1316 (84 %). All polyps were removed endoscopically: using of biopsy forcepts for polyps up to 3 mm - 267 (17 %) - first group, with a cold snare - polyps 6-10 mm 1081 (69 %) - second group and using the EMR method flat polyps 9 -10 mm 125 (8 %) and 94 (6 %) pedunculated polyps - third group. The polyps were removed «en-bloс» in 1395 (89 %), in 172 (11 %) residual tissue at the edge of the defect removed immediately with biopsy forceps or a cold snare. Assessment of the presence of residual tissue is more difficult after EMR due to postcoagulant necrosis.
Effectiveness of Right Heart Catheterization: Time for a Randomized Trial
Authors: Robert J. Jackson
Journal: JAMA (1997)

<h3>To the Editor.</h3> —Perhaps the Editorial by Drs Dalen and Bone<sup>1</sup>should have specified a moratorium on the use of flowdirected PA catheters in the subset of patients who were observed by Dr Connors and colleagues<sup>2</sup>: patients with acute respiratory failure, chronic obstructive pulmonary disease, congestive heart failure, cirrhosis, nontraumatic coma, colon cancer metastatic to the liver, non-small cell lung cancer, and multiorgan system failure. Right heart catheterization has been shown to be beneficial for certain patients with trauma, head injury, and subarachnoid hemorrhage who were not included in this study. Cerebral vasospasm and subsequent delayed cerebral ischemia are the major cause of death and disability in patients who initially survive cerebral aneurysm rupture. By increasing cerebral blood flow, hypertensive hypervolemic hemodilution ("triple-H" therapy) has been shown to reduce the incidence of clinical vasospasm and to reverse neurologic deficits that develop in patients with cerebral vasospasm.<sup>3</sup>Right heart catheterization and
Hazards for elderly people admitted for respite and social care
Authors: E. Murphy
Journal: BMJ (1986)

during their stay.But the term "social admission" is inaccurate-"desperate admission" would be more pertinent.These patients have usually experienced a rapid deterioration in their health before admission, due to organic brain syndromes, multiple system disease, or severe physical frailty, and sometimes all three.The high mortality rate from these medical conditions is therefore scarcely surprising.The authors present no data on their patients' health before admission for us to judge their-pre- existing morbidity.Labelling chronically ill elderly patients as "social problems" contributes to therapeutic des- pondency in the ward team.It is also unfair and demeaning-elderly people do not deserve to be bracketed with soccer hooligans.
Efficient repopulation of denuded rabbit arteries with autologous genetically modified endothelial cells.
Authors: M SConte, L KBirinyi, TMiyata, J TFallon, H KGold, A DWhittemore, R CMulligan
Journal: Circulation (1994)

BACKGROUNDIn an effort to determine whether specific genetic modifications of cells of the vascular system might improve the efficacy of existing clinical procedures such as endarterectomy, atherectomy, and percutaneous angioplasty, we investigated the utility of gene transfer to rapidly and efficiently repopulate injured arteries with genetically modified cells in an animal model.METHODS AND RESULTSThe method involves the harvest of autologous venous-derived endothelial cells, the efficient genetic modification of the cells through the use of recombinant retroviruses, and the subsequent implantation of the genetically modified cells on the surface of balloon-denuded arterial segments. With a rabbit model, freshly isolated endothelial cells were transduced with a recombinant retrovirus encoding the bacterial enzyme beta-galactosidase. The autologous transduced cells were then implanted on the surface of balloon-denuded ileofemoral arterial segments at different cell densities; after 1 to 14 days, the anim...
High-density lipoprotein cholesterol and prognosis after myocardial infarction.
Authors: K GBerge, P LCanner, AHainline
Journal: Circulation (1982)

The Coronary Drug Project was a randomized, placebo-controlled trial of lipid-influencing drugs in men who had recovered from one or more documented myocardial infarctions. Determinations of high-density lipoprotein (HDL) cholesterol were made at baseline in a group of 354 men randomized to the placebo group. Five-year mortality was highest (33.0%) in men with baseline serum HDL cholesterol levels of less than 35 mg/dl; it was 15.9%, 17.7%, and 21.8% in men with levels of 35--39, 40--44, and greater than or equal to 45 mg/dl, respectively (for the linear inverse relationship between HDL cholesterol and 5-year mortality, p = 0.029). Adjustment for 40 baseline variables had a minimal effect on this relationship (p = 0.042).
Sound pressure correlates of the Austin Flint murmur. An intracardiac sound study.
Authors: P SReddy, E ICurtiss, RSalerni, J DO'Toole, F WGriff, D FLeon, J AShaver
Journal: Circulation (1976)

Mitral valve motion and pressure correlates of the Austin Flint murmur (AFM) were investigated in nine patients with aortic regurgitation using high fidelity catheter tip micromanometers and the mitral valve echocardiogram (MVE). External phonocardiography demonstrated a mid-diastolic murmur (MDM) in eight subjects and a presystolic murmur (PSM) in five. Maximum intensity of both AFM components was found in the left ventricular (LV) inflow tract; the murmur was not recordable in the left atrium (LA). In two patients, an apparent AFM was recorded in the intracardiac phonocardiogram when absent externally. Only one subject had a significant late diastolic reversed or LV to LA gradient; in this patient, presystolic mitral regurgitation was shown angiographically but no PSM was present and MVE revealed absence of atriogenic mitral valve re-opening. In two subjects, a PSM disappeared from the external phono when a reversed gradient occurred during the diastolic pause following a ventricular premature systo...
The Symbol of Modern Medicine
Authors: David P. Steensma
Journal: Annals of Internal Medicine (2004)

Letters17 February 2004The Symbol of Modern MedicineDavid P. Steensma, MDDavid P. Steensma, MDFrom Mayo Clinic; Rochester, MN 55905.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-4-200402170-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:After reading the interesting review of the chronic confusion in the United States between the caduceus and Asklepian symbols (1), I wondered whether the twin-serpent emblem of Hermes—god of commerce and wealth, patron of merchants and thieves, and escort of the dying to the underworld—might be the more appropriate symbol for U.S. medicine at present. Asklepios was a “focus of … supplication … for the poor and disregarded” (1). While the poor continue to be disregarded and have little access to physicians outside of last-resort settings such as chaotic emergency departments, merchant medicine is thriving. Medical practice ...References1. Wilcox RA, Whitham EM. The symbol of modern medicine: why one snake is more than two. Ann Intern Med. 2003;138:673-7. [PMID: 12693891] LinkGoogle Scholar2. Kassirer JP. Managed care and the morality of the marketplace [Editorial]. N Engl J Med. 1995;333:50-2. [PMID: 7776996] CrossrefMedlineGoogle Scholar3. Numbers 21:9 (KJV). Google Scholar Author, Article, and Disclosure InformationAffiliations: From Mayo Clinic; Rochester, MN 55905. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Symbol of Modern Medicine: Why One Snake Is More Than Two* Robert A. Wilcox and Emma M. Whitham The Symbol of Modern Medicine Konstantinos Paparounas The Symbol of Modern Medicine Jamie Newman The Symbol of Modern Medicine Robert A. Wilcox and Emma M. Whitham The Symbol of Modern Medicine Michael E. Toedt and Dominique M. Gooby Toedt The Symbol of Modern Medicine Neni Prasad The Symbol of Modern Medicine Adrian G. Letz The Symbol of Modern Medicine Drew Hause The Symbol of Modern Medicine Meyer D. Lifschitz The Symbol of Modern Medicine Sarkis J. Chobanian Metrics Cited byCaduceus or Rod of Asclepius? Exploring Logos of University Teaching Hospitals in Nigeria 17 February 2004Volume 140, Issue 4Page: 311KeywordsEmergency departmentHealth careHeartRiversSuicideWilderness ePublished: 17 February 2004 Issue Published: 17 February 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Development Of Pathology Detection Algorithms Based On Convolutional Neural Networks (CNN)
Authors: V Khryashchev, S Kashin, A Merkulova, O Stepanova, A Srednyakova, E Tarasova, E Kazina
Journal: Endoscopy (2021)

Aims Development and research of algorithms for detecting pathologies in endoscopic images of stomach based on different architectures of CNN.
Birth defects linked with specific level of maternal alcohol use, but abstinence still is the best policy
Authors: C. A. Raymond
Journal: JAMA (1987)

FOR THE CHILD-TO-BE, how much of mother's drinking is too much? New data from an ongoing study indicate that the level of prenatal alcohol exposure associated with increased risk for anatomic congenital anomalies is more than four drinks per day. This cutoff off point put 2% of more than 8300 mothers in this study in the high-risk group, according to Robert J. Sokol, MD, who spoke at the American College of Obstetricians and Gynecologists meeting in Las Vegas. The idea that there is a threshold level for alcohol-related effects remains controversial, according to Boris Tabakoff, MD, scientific director of intramural programs at the National Institute on Alcohol Abuse and Alcoholism (NIAAA). "It is hard to talk about a threshold effect when the question is 'What effect? ' " Tabakoff said in a telephone interview. He points out that alcohol can exert numerous effects, some obvious—such as anatomic defects—others more subtle, such as
Effect of the thyroid state on the enzymatic characteristics of cardiac myosin. A difference in behavior of rat and rabbit cardiac myosin.
Authors: YYazaki, M SRaben
Journal: Circulation Research (1975)

The effect of thyroid state on the activity of myosin adenosinetriphosphatase (ATPase) was examined in the rat and the rabbit. Cardiac myosin from thyroxine-treated rabbits showed enzymatic properties characterized by high Ca2plus-activated ATPase activity, low activation energy, lower rate of inactivation at alkaline pH, and no activation by N-ethylmaleimide compared with the same properties in the normal rabbit; thyroidectomy did not affect the enzymatic properties of rabbit cardiac myosin. These findings suggest a difference in the myosin molecule at or near the active site, involving some sulfhydryl groups, between hyperthyroid and euthyroid rabbits. However, rat cardiac myosin showed a pattern of activity in the euthyroid state similar to that of the hyperthyroid rabbit and changed to the euthyroid type after thyroidectomy. These changes were specific for cardiac myosin, since no change was observed in skeletal myosin. It is unlikely that there are major differences in the myosin molecule associated ...
A genetically encoded sensor for measuring serotonin dynamics
Authors: Jinxia Wan, Wanling Peng, Xuelin Li, Tongrui Qian, Kun Song, Jianzhi Zeng, Fei Deng, Suyu Hao, Jiesi Feng, Peng Zhang, Yajun Zhang, Jing Zou, Sunlei Pan, Mimi Shin, B. Jill Venton, J. Julius Zhu, Miao Jing, Min Xu, Yulong Li
Journal: Nature Neuroscience (2021)
Foreign Body in the Biliary Tree: A New Complication Associated With ERCP
Authors: P Florez-Diez, N Rodriguez-Ferreiro, V Beltran, A Lopez-Mourelle, S Lamas, P Arguelles-Estrada, C del Caño-Cerdan, A Nieto-Jara, A Suarez-Noya, A Gejo, M Celada-Sendino, L Carballo-Folgoso, M Fraile, E Barreiro-Alonso, O Garcia-Bernardo, A Garcia-Menendez
Journal: Endoscopy (2021)

A man with liver abscesses and choledocholithiasis. ERCP with sphincterotomy and stone extraction with balloon catheter. Once antibiotic was completed, a CT showed a liver abscessesn improvement, identifying a metallic foreign body of 20 mm in liver segment VIII, suggestive of balloon catheter fragment. Extraction was attempted with a new ERCP and percutaneously, without success. At the same time as open cholecystectomy, it was attempted surgical extraction, but intraoperative ultrasound showed an intimate relationship with a large portal branch, giving up the attempt. Subsequent radiological controls have been carried out, without alterations, so an expectant attitude has been maintained.