tbuckley/cabot-search huggingface dataset:
Abstract 17077: Nocturnal Intermittent Hypoxia and Short Sleep Duration were Independently Associated With Elevated C-reactive Protein Level in Patients With Coronary Artery Disease
Authors: Ryoma Fukuoka, Takashi Kohno, Shun Kohsaka, Ryo Yanagisawa, Takahiko Nishiyama, Yuichiro Maekawa, Motoaki Sano, Keiichi Fukuda
Journal: Circulation (2015)

Introduction: There is growing evidence of a relationship between sleep disorders and cardiovascular diseases including coronary artery disease (CAD). However, the mechanism of these association is not well established. Enhanced vascular inflammation is implicated as a pathophysiologic mechanism in CAD. The aim of this study was to evaluate the relationship among sleep-disordered breathing (SDB), sleep duration, and serum C-reactive protein (CRP) level in patients with CAD. Methods and Results: Consecutive 225 patients with CAD who underwent percutaneous coronary intervention were evaluated. We used a nocturnal pulse oximetry as a non-invasive screening method for nocturnal intermittent hypoxia, a surrogate marker of SDB. Nocturnal intermittent hypoxia was evaluated using 3% oxygen desaturation index (3% ODI) which was the number of oxygen desaturation measurement ≤ 3% per hour, and we divided the patients into nocturnal intermittent hypoxia group (3% ODI≥15; n=64) and control group (3% ODI&lt;15; n=161). Sleep quality was assessed using validated questionnaires (Pittsburgh Sleep Quality Index [PSQI]; 5.3±3.4, sleep duration; 385±83 minutes). Nocturnal intermittent hypoxia group had significantly higher BMI compared with control group, but age, gender, other coronary risk factors, sleep disturbance (PSQI≥8), sleep duration, and angiographic findings did not differ between two groups. Laboratory data showed that serum CRP level was significantly higher in patients with nocturnal intermittent hypoxia (0.15 [0.09-0.33] vs 0.06 [0.02-0.21] mg/dl, p=0.003). Short sleep duration (&lt;6 hours) was also associated with increased CRP level (0.22 [0.04-0.40] vs 0.07 [0.03-0.14] mg/dl, p=0.036). In multiple regression analysis adjusted by age, gender, BMI, and acute coronary syndrome, 3% ODI (β=0.25; p=0.016; 95% CI, 0.153 to 1.475) and short sleep duration (β=0.20; p=0.04; 95% CI, 0.022 to 1.299) were independent determinants for log serum CRP level. Conclusions: Nocturnal intermittent hypoxia and short sleep duration were independently associated with elevated serum CRP level in CAD patients, suggesting that SDB and sleep duration could be important modifiable factors for the clinical management of patients with CAD.
Development of pathological reconstructed high‐resolution images using artificial intelligence based on whole slide image
Authors: Yang Deng, Min Feng, Yong Jiang, Yanyan Zhou, Hangyu Qin, Fei Xiang, Yizhe Wang, Hong Bu, Ji Bao
Journal: MedComm (2020)

Pathology plays a very important role in cancer diagnosis. The rapid development of digital pathology (DP) based on whole slide image (WSI) has led to many improvements in computer-assisted diagnosis by artificial intelligence. The common digitization strategy is to scan the pathology slice with 20× or 40× objective, and the 40× objective requires excessive storage space and transmission time, which are significant negative factors in the popularization of DP. In this article, we present a novel reconstructed high-resolution (HR) process based on deep learning to switch 20 × WSI to 40 × without the loss of whole and local features. Furthermore, we collected the WSI data of 100 uterine leiomyosarcomas and 100 adult granulosa cell tumors to test our reconstructed HR process. We tested the reconstructed HR WSI by the peak signal-to-noise ratio, structural similarity, and the blind/reject image spatial quality evaluator, which were 42.03, 0.99, and 49.22, respectively. Subsequently, we confirmed the consistency between the actual and our reconstructed HR images. The testing results indicate that the reconstructed HR imaging is a reliable method for the digital slides of a variety of tumors and can be available on a large scale in clinical pathology as an innovative technique.
CSN8 is a key regulator in hypoxia-induced epithelial–mesenchymal transition and dormancy of colorectal cancer cells
Authors: Songwen Ju, Feng Wang, Yirong Wang, Songguang Ju
Journal: Molecular Cancer (2020)

Abstract Hypoxic stress plays a pivotal role in cancer progression; however, how hypoxia drives tumors to become more aggressive or metastatic and adaptive to adverse environmental stress is still poorly understood. In this study, we revealed that CSN8 might be a key regulatory switch controlling hypoxia-induced malignant tumor progression. We demonstrated that the expression of CSN8 increased significantly in colorectal cancerous tissues, which was correlated with lymph node metastasis and predicted poor patient survival. CSN8 overexpression induces the epithelial-mesenchymal transition (EMT) process in colorectal cancer cells, increasing migration and invasion. CSN8 overexpression arrested cell proliferation, upregulated key dormancy marker (NR2F1, DEC2, p27) and hypoxia response genes ( HIF-1α, GLUT1 ), and dramatically enhanced survival under hypoxia, serum deprivation, or chemo-drug 5-fluorouracil treatment conditions. In particular, silenced CSN8 blocks the EMT and dormancy processes induced by the hypoxia of 1% O 2 in vitro and undermines the adaptive capacity of colorectal cancer cells in vivo. The further study showed that CSN8 regulated EMT and dormancy partly by activating the HIF-1α signaling pathway, which increased HIF-1α mRNA expression by activating NF-κB and stabilized the HIF-1α protein via HIF-1α de-ubiquitination. Taken together, CSN8 endows primary colorectal cancer cells with highly aggressive/metastatic and adaptive capacities through regulating both EMT and dormancy induced by hypoxia. CSN8 could serve as a novel prognostic biomarker for colorectal cancer and would be an ideal target of disseminated dormant cell elimination and tumor metastasis, recurrence, and chemoresistance prevention.
17489 Effects of semiablative fractional radiofrequency associated with growth factors in striae alba treatment: A randomized clinical trial
Authors: Patricia Meyer, Rodrigo Marcel Valentim da Silva’, Ciro Dantas Soares, Eneida Carreiro, Louhanne Christine Berto Bezerra, Maria Paula Marques Oliveira
Journal: Journal of the American Academy of Dermatology (2020)
White House demands to know how UK approved vaccine before FDA
Authors: Owen Dyer
Journal: BMJ (2020)

The UK’s approval of the Pfizer BioNTech covid-19 vaccine1 has ratcheted up the pressure on the US Food and Drug Administration (FDA) and its commissioner Stephen Hahn, who was called to the White House this week to explain why the US would not be first to distribute a vaccine.

Two anonymous senior administration officials told the news website Axios that Hahn had been summoned by White House chief of staff Mark Meadows because “there are some who are complaining the FDA is not working around the clock to get things approved.” Hahn’s request to conduct the meeting by telephone had been denied, they said, adding that the FDA commissioner would be asked to explain why, in mid-November, he spent a week “vacationing.”

The hostile press briefing prompted an FDA statement, which said that following a potential exposure to coronavirus, Hahn “chose a remote location to quarantine and he continued working, …
Induction of labor versus expectant management in women with preterm prelabor rupture of membranes between 34 and 37 weeks: A randomiz
Authors: D.P. van deHam, S.M.C. Vijgen, J.G. Nijhuis, J.J. vanBeek, B.C. Opmeer, A.L.M. Mulder, R.M.J. Moonen, M. Groenewout, M.G. vanPampus, G.D. Mantel, K.W.M. Bloemenkamp, W.J. vanWijngaarden, M.J. Sikkema, M.C. Haak, P.J.M. Pernet, M. Porath, J.F.M. Molkenboer, S. Kuppens, A. Kwee, M.M. Kars, Woiski, M.J.N. Weinans, H.I.J. Wildschut, B.M.C. Akerboom, B.W.J. Mol, C. Willekes
Journal: PLoS Medicine (2012)

textabstractBackground: At present, there is insufficient evidence to guide appropriate management of women with preterm prelabor rupture of membranes (PPROM) near term. Methods and Findings: We conducted an open-label randomized controlled trial in 60 hospitals in The Netherlands, which included non-laboring women with >24 h of PPROM between 34 +0 and 37 +0 wk of gestation. Participants were randomly allocated in a 1:1 ratio to induction of labor (IoL) or expectant management (EM) using block randomization. The main outcome was neonatal sepsis. Secondary outcomes included mode of delivery, respiratory distress syndrome (RDS), and chorioamnionitis. Patients and caregivers were not blinded to randomization status. We updated a prior meta-analysis on the effect of both interventions on neonatal sepsis, RDS, and cesarean section rate. From 1 January 2007 to 9 September 2009, 776 patients in 60 hospitals were eligible for the study, of which 536 patients were randomized. Four patients were excluded after randomization. We allocated 266 women (268 neonates) to IoL and 266 women (270 neonates) to EM. Neonatal sepsis occurred in seven (2.6%) newborns of women in the IoL group and in 11 (4.1%) neonates in the EM group (relative risk [RR] 0.64; 95% confidence interval [CI] 0.25 to 1.6). RDS was seen in 21 (7.8%, IoL) versus 17 neonates (6.3%, EM) (RR 1.3; 95% CI 0.67 to 2.3), and a cesarean section was performed in 36 (13%, IoL) versus 37 (14%, EM) women (RR 0.98; 95% CI 0.64 to 1.50). The risk for chorioamnionitis was reduced in the IoL group. No serious adverse events were reported. Updating an existing meta-analysis with our trial results (the only eligible trial for the update) indicated RRs of 1.06 (95% CI 0.64 to 1.76) for neonatal sepsis (eight trials, 1,230 neonates) and 1.27 (95% CI 0.98 to 1.65) for cesarean section (eight trials, 1,222 women) for IoL compared with EM. Conclusions: In women whose pregnancy is complicated by late PPROM, neither our trial nor the updated meta-analysis indicates that IoL substantially improves pregnancy outcomes compared with EM.
Conductive Materials for Healing Wounds: Their Incorporation in Electroactive Wound Dressings, Characterization, and Perspectives
Authors: Chiranjeevi Korupalli, Hui Li, Nhien Nguyen, Fwu‐Long Mi, Yen Chang, Yu‐Jung Lin, Hsing‐Wen Sung
Journal: Advanced Healthcare Materials (2020)

Abstract The use of conductive materials to promote the activity of electrically responsive cells is an effective means of accelerating wound healing. This article focuses on recent advancements in conductive materials, with emphasis on overviewing their incorporation with non‐conducting polymers to fabricate electroactive wound dressings. The characteristics of these electroactive dressings are deliberated, and the mechanisms on how they accelerate the wound healing process are discussed. Potential directions for the future development of electroactive wound dressings and their potential in monitoring the course of wound healing in vivo concomitantly are also proposed.
Exploring Mechanisms of Graft Occlusion: Toward Improved Outcomes in Coronary Artery Bypass Graft Surgery⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Authors: Robert F. Storey
Journal: Journal of the American College of Cardiology (2011)
Immunosuppressive Drug‐Resistant Armored T‐Cell Receptor T Cells for Immune Therapy of HCC in Liver Transplant Patients
Authors: Morteza Hafezi, Meiyin Lin, Adeline Chia, Alicia Chua, Zi Zong Ho, Royce Fam, Damien Tan, Joey Aw, Andrea Pavesi, Thinesh Lee Krishnamoorthy, Wan Cheng Chow, Wenjie Chen, Qi Zhang, Lu‐En Wai, Sarene Koh, Anthony T. Tan, Antonio Bertoletti
Journal: Hepatology (2020)

Background and Aims HBV‐specific T‐cell receptor (HBV‐TCR) engineered T cells have the potential for treating HCC relapses after liver transplantation, but their efficacy can be hampered by the concomitant immunosuppressive treatment required to prevent graft rejection. Our aim is to molecularly engineer TCR‐T cells that could retain their polyfunctionality in such patients while minimizing the associated risk of organ rejection. Approach and Results We first analyzed how immunosuppressive drugs can interfere with the in vivo function of TCR‐T cells in liver transplanted patients with HBV‐HCC recurrence receiving HBV‐TCR T cells and in vitro in the presence of clinically relevant concentrations of immunosuppressive tacrolimus (TAC) and mycophenolate mofetil (MMF). Immunosuppressive Drug Resistant Armored TCR‐T cells of desired specificity (HBV or Epstein‐Barr virus) were then engineered by concomitantly electroporating mRNA encoding specific TCRs and mutated variants of calcineurin B (CnB) and inosine‐5′‐monophosphate dehydrogenase (IMPDH), and their function was assessed through intracellular cytokine staining and cytotoxicity assays in the presence of TAC and MMF. Liver transplanted HBV‐HCC patients receiving different immunosuppressant drugs exhibited varying levels of activated (CD39 + Ki67 + ) peripheral blood mononuclear cells after HBV‐TCR T‐cell infusions that positively correlate with clinical efficacy. In vitro experiments with TAC and MMF showed a potent inhibition of TCR‐T cell polyfunctionality. This inhibition can be effectively negated by the transient overexpression of mutated variants of CnB and IMPDH. Importantly, the resistance only lasted for 3‐5 days, after which sensitivity was restored. Conclusions We engineered TCR‐T cells of desired specificities that transiently escape the immunosuppressive effects of TAC and MMF. This finding has important clinical applications for the treatment of HBV‐HCC relapses and other pathologies occurring in organ transplanted patients.
15119 Reducing the pain of intramuscular benzathine penicillin injection in syphilis by using 1% lidocaine as a diluent: A prospective, randomized, double-blinded trial study
Authors: Sukhum Jiamton, Ya-Nin Nokdhes, Pichaya Limphoka, Poramin Patthamalai, Ploypailin Tantrapornping, Nuttagarn Jantanapornchai, Viboon Omcharoen
Journal: Journal of the American Academy of Dermatology (2020)
A Phase II Trial Evaluating the Efficacy of Radioiodinated Tositumomab (Anti-CD20) Antibody, Etoposide and Cyclophosphamide Followed By Autologous Transplantation, for High-Risk Relapsed or Refractory Non-Hodgkin's Lymphoma
Authors: Victor A. Chow, Joseph Rajendren, Andrew Shields, Darrell R. Fisher, Frederick R. Appelbaum, Ryan D. Cassaday, Andrew J. Cowan, Paul J. Martin, Leona Holmberg, Ted Gooley, Philip A. Stevenson, John M. Pagel, Damian J. Green, Oliver W. Press, Ajay K. Gopal
Journal: Blood (2017)
70MO Efficacy and safety of envafolimab (KN035) in advanced tumours with mismatch-repair deficiency
Authors: L. Shen, J. Li, Y. Deng, W. Zhang, A. Zhou, W. Guo, J. Yang, Y. Yuan, L. Zhu, S. Qin, S. Xiang, L. Li, H. Lu, J. Gong, T. Xu, D. Liu
Journal: Annals of Oncology (2020)
Covid-19: GPs have “stepped up” in time of national crisis, says profession’s leader
Authors: Abi Rimmer
Journal: BMJ (2020)

Covid-19: GPs have "stepped up" in time of national crisis, says profession's leader Abi RimmerGPs have gone the extra mile to support their patients during the covid-19 pandemic and deserve praise for their efforts, the chair of the BMA's GP committee has said.Speaking at the 2020 annual conference of England's local medical committees, Richard Vautrey thanked GPs and their teams for their hard work."Thank you to all those in general practice and primary care who have worked tirelessly and with huge commitment and dedication throughout this year, a year like no other," he said."Throughout the whole of the covid-19 pandemic, from day one to today, general practice has been open for business."But Vautrey also criticised the government's response to the pandemic."Guidance was delayed, initiatives too limited, and funding too little," he said.He said there had been a lack of government funding to cover the additional work done by GP practices early in the pandemic, but said he was pleased that the BMA had secured a further £150m (€168m; $200m) to support additional capacity in practices.Commenting on the role that GPs will play in the upcoming covid-19 vaccination campaign, Vautrey said there were no better people to take on the task."Whether we work in local groups or more regional centres, once a safe and effective vaccine is available, our practice teams will work to the best of our considerable ability to protect our patients as quickly as possible," he said."And while we may have superpowers, we cannot be in two places at once and so we will need the help of everyone, we'll need to be able to prioritise the rest of our workload and crucially we'll need the understanding of our patients in doing so.We will need all hands to the pump.
428P Prognostic value of clinico-pathological characteristics and peripheral monocyte counts in localised extra-meningeal solitary fibrous tumours treated with surgical resection
Authors: R.M.H. Lim, H. Jiancheng, G. Wei Lin, E.W.Y. Chang, V.S. Yang, E.Y.L. Poon, N. Somasundaram, M. Farid, J.Y. Chan
Journal: Annals of Oncology (2020)
Abstract PO-021: Cell identity determines TCA cycle dynamics
Authors: Paige K. Arnold, Benjamin T. Jackson, Sydney Alibeckoff, Esther Drill, Lucas B. Sullivan, Lydia W.S. Finley
Journal: Cancer Research (2020)

Abstract Cells utilize diverse metabolic strategies to support cell type-specific bioenergetic requirements. The enzymes that mediate cellular metabolic processes have been well studied. However, how cells coordinate these factors into metabolic networks remains poorly understood. Here we use measurements of gene dependency across hundreds of cancer cell lines to cluster metabolic genes into co-dependent modules. These analyses identified two distinct tricarboxylic acid (TCA) cycle modules with specific genetic dependencies. Isotope tracing combined with genetic manipulation of TCA cycle modules revealed that both normal stem cells and cancer cells can engage two different modes of TCA cycle metabolism. Enforcing self-renewal or differentiation induced preferential use of one TCA cycle module over another, indicating that TCA cycle dynamics are determined by cell state. In turn, the mode of TCA cycle metabolism employed by cells dictated nutrient dependencies, enabling cell-type specific responses to nutrient deprivation. Collectively, these studies reveal that TCA cycle behavior is dynamic and can be rerouted to confer a selective advantage to cells under different nutrient conditions. Citation Format: Paige K. Arnold, Benjamin T. Jackson, Sydney Alibeckoff, Esther Drill, Lucas B. Sullivan, Lydia W.S. Finley. Cell identity determines TCA cycle dynamics [abstract]. In: Abstracts: AACR Special Virtual Conference on Epigenetics and Metabolism; October 15-16, 2020; 2020 Oct 15-16. Philadelphia (PA): AACR; Cancer Res 2020;80(23 Suppl):Abstract nr PO-021.
Convergence of 3D printed biomimetic wound dressings and adult stem cell therapy
Authors: Abbas Shafiee, Amanda S. Cavalcanti, Navid T. Saidy, Dominik Schneidereit, Oliver Friedrich, Akhilandeshwari Ravichandran, Elena M De-Juan-Pardo, Dietmar W. Hutmacher
Journal: Biomaterials (2020)
Incidence and risk factors of second primary cancer after the initial primary human papillomavirus related neoplasms
Authors: Jiayi Shen, Huaqiang Zhou, Jiaqing Liu, Zhonghan Zhang, Wenfeng Fang, Yunpeng Yang, Shaodong Hong, Wei Xian, Yuxiang Ma, Ting Zhou, Yaxiong Zhang, Hongyun Zhao, Yan Huang, Li Zhang
Journal: MedComm (2020)

Comprehensive studies in second primary cancer (SPC) after the initial primary human papillomavirus (HPV)-related cancer still remain warranted. We aimed to analyze the incidence and risk factors of SPC after HPV-related cancer. We identified 86 790 patients diagnosed with initial primary HPV-related cancer between 1973 and 2010 in the SEER database. Standardized incidence ratio (SIR) and cumulative incidence were calculated to assess the risk of SPC after HPV-related cancer. The SIR of SPC after HPV-related cancer was 1.60 (95% confidence interval [CI], 1.55-1.65) for male and 1.25 (95% CI, 1.22-1.28) for female. SIR of second primary HPV-related cancer (7.39 [95% CI, 6.26-8.68] male and 4.35 [95% CI, 4.04-4.67] female) was significantly higher than that of HPV-unrelated cancer (1.54 [95% CI, 1.49-1.60] male and 1.16 [95% CI, 1.13-1.19] female). The 5-year cumulative incidence of SPC was 7.22% (95% CI, 6.89-7.55%) for male and 3.72% (95% CI, 3.58-3.88%) for female. Risk factors for SPC included being married and having initial primary cancer (IPC) diagnosed at earlier stage for both genders, and IPC diagnosed at older age as well as surgery performed for female. Patients diagnosed with HPV-related cancer are more likely to develop another primary cancer, compared with the age-specific reference population.
Genetic Architecture and Fitness of Bacterial Interspecies Hybrids
Authors: Katrin Bartke, Linnéa Garoff, Douglas L Huseby, Gerrit Brandis, Diarmaid Hughes
Journal: Molecular Biology and Evolution (2020)

Integration of a conjugative plasmid into a bacterial chromosome can promote the transfer of chromosomal DNA to other bacteria. Intraspecies chromosomal conjugation is believed responsible for creating the global pathogens Klebsiella pneumoniae ST258 and Escherichia coli ST1193. Interspecies conjugation is also possible but little is known about the genetic architecture or fitness of such hybrids. To study this, we generated by conjugation 14 hybrids of E. coli and Salmonella enterica. These species belong to different genera, diverged from a common ancestor >100 Ma, and share a conserved order of orthologous genes with ∼15% nucleotide divergence. Genomic analysis revealed that all but one hybrid had acquired a contiguous segment of donor E. coli DNA, replacing a homologous region of recipient Salmonella chromosome, and ranging in size from ∼100 to >4,000 kb. Recombination joints occurred in sequences with higher-than-average nucleotide identity. Most hybrid strains suffered a large reduction in growth rate, but the magnitude of this cost did not correlate with the length of foreign DNA. Compensatory evolution to ameliorate the cost of low-fitness hybrids pointed towards disruption of complex genetic networks as a cause. Most interestingly, 4 of the 14 hybrids, in which from 45% to 90% of the Salmonella chromosome was replaced with E. coli DNA, showed no significant reduction in growth fitness. These data suggest that the barriers to creating high-fitness interspecies hybrids may be significantly lower than generally appreciated with implications for the creation of novel species.
118MO Circulating tumour DNA methylation are markers for early detection of pancreatic ductal adenocarcinoma (PDAC)
Authors: X. Liu, Q. He, Z. Liang, H. Wu, Y. Li, Z. Zhang, L. Yu, M. Dai, S. Guo, G. Jin, S. Shen, Z. Su, C. Ma, Z. Xie, R. Liu
Journal: Annals of Oncology (2020)
LBA 1 Baseline characteristics of patients from Asia enrolled in monarchE, evaluating abemaciclib in high risk early breast cancer
Authors: Z. Jiang, T. Nakayama, S. Nakamura, S-C. Lee, S-C. Chen, J. Feng, J.H. Tang, M. Saito, Y. Miyoshi, C-L. Liu, H.K. Ahn, S. Sherwood, A. Zimmermann, J. Cox, I.H. Park
Journal: Annals of Oncology (2020)
Direct impact of gonadotropins on glucose uptake and storage in preovulatory granulosa cells: Implications in the pathogenesis of polycystic ovary syndrome
Authors: Nidhi Chahal, Anjali Geethadevi, Surleen Kaur, Ruchi Lakra, Anjali Nagendra, T.G. Shrivastav, Francesco De Pascali, Eric Reiter, Pascale Crépieux, M. Gouri Devi, Neena Malhotra, K. Muralidhar, Rita Singh
Journal: Metabolism (2020)