tbuckley/cabot-search huggingface dataset:
Regional myocardial oxygen consumption determined noninvasively in humans with [1-11C]acetate and dynamic positron tomography.
Authors: J JArmbrecht, D BBuxton, R CBrunken, M EPhelps, H RSchelbert
Journal: Circulation (1989)

Experimental studies of animals have previously demonstrated the validity of [1-11C]acetate as a tracer of oxidative metabolism for use with positron emission tomography. The present study was undertaken to define in normal human volunteers the relation between myocardial clearance kinetics of [1-11C]acetate, and the rate-pressure product as an index of myocardial oxygen consumption. Twenty-two studies were performed of 12 volunteers. The rate-pressure product was increased with continuous supine bicycle exercise in six studies. Of the 16 resting studies, seven were performed in the fasted state and nine following an oral glucose load, to define possible effects of substrate availability on the tracer-tissue kinetics. Myocardial tissue time-activity curves were biexponential. Clearance of activity was homogeneous throughout the myocardium. The rate constants k1, obtained from biexponential fitting, and kmono, obtained by monoexponential fitting of the initial linear portion of the time-activity curves, co...
Atrial stretch, not pressure, is the principal determinant controlling the acute release of atrial natriuretic factor.
Authors: B SEdwards, R SZimmerman, T RSchwab, D MHeublein, J CBurnett
Journal: Circulation Research (1988)

The current studies were designed to investigate the mechanisms in the intact anesthetized dog that control the release of atrial natriuretic factor (ANF). In vitro, mechanical stretch of atrial tissue produces an increased release of ANF. In vivo, changes in atrial pressure correlate positively with circulating ANF levels. The present investigations used 6 open-chest anesthetized dogs to evaluate the role of atrial pressure versus atrial stretch, the latter determined by atrial transmural pressure, in the release of ANF. In a paired design, animals underwent cardiac tamponade followed by constriction of the aorta and pulmonary artery. Tamponade produces a balanced increase in intra-atrial and pericardial pressures. Thus, despite an elevated atrial pressure, there is no increase in transmural pressure producing atrial stretch. Great artery constriction increases intra-atrial but not pericardial pressure, resulting in an increase in atrial transmural pressure and atrial stretch. Cardiac tamponade increased...
Integration of QSAR and in vitro toxicology.
Authors: M D Barratt
Journal: Environmental Health Perspectives (1998)

The principles of quantitative structure-activity relationships (QSAR) are based on the premise that the properties of a chemical are implicit in its molecular structure. Therefore, if a mechanistic hypothesis can be proposed linking a group of related chemicals with a particular toxic end point, the hypothesis can be used to define relevant parameters to establish a QSAR. Ways in which QSAR and in vitro toxicology can complement each other in development of alternatives to live animal experiments are described and illustrated by examples from acute toxicological end points. Integration of QSAR and in vitro methods is examined in the context of assessing mechanistic competence and improving the design of in vitro assays and the development of prediction models. The nature of biological variability is explored together with its implications for the selection of sets of chemicals for test development, optimization, and validation. Methods are described to support the use of data from in vivo tests that do not meet today's stringent requirements of acceptability. Integration of QSAR and in vitro methods into strategic approaches for the replacement, reduction, and refinement of the use of animals is described with examples.
Incidence and significance of left anterior hemiblock complicating acute inferior wall myocardial infarction.
Authors: PKourtesis, ELichstein, K DChadda, P KGupta
Journal: Circulation (1976)

The hospital course and serial vectorcardiograms of 56 consecutive patients with acute inferior wall myocardial infarction were reviewed. Left anterior hemiblock (LAH) complicating inferior wall myocardial infarction was diagnosed by vectorcardiographic criteria. Seven patients (12.5%) developed LAH between the first and third hospital day, while 49 patients did not. There was no significant difference between these two groups when compared for age, sex, incidence of congestive heart failure, atrial and ventricular arrhythmias, atrioventricular (A-V) block, hospital mortality, and previous hypertension, diabetes mellitus, and myocardial infarction. We conclude that LAH is a relatively common complication of acute inferior wall myocardial infarction, with no apparent effect on the clinical course.
Cutaneous squamous cell carcinoma is associated with Lynch syndrome: widening the spectrum of Lynch syndrome‐associated tumours
Authors: B.L.M. Ykema, F. Adan, M.B. Crijns, F.E. Bleeker, E. Dekker, M.W. Bekkenk, P. Snaebjornsson, M.E. van Leerdam
Journal: British Journal of Dermatology (2021)
Endoscopic Drainage- Plastic Versus Metal Stent in Palliative Treatment of Malignant Distal Biliary Obstruction: a Systematic Review and Meta-Analysis
Authors: MV Cury Vieira Scatimburgo, I Braga Ribeiro, V Massari Takamatsu Sagae, DTH de Moura, B Salomão Hirsch, M Bond Boghossian, W Marques Bernardo, M Eduardo Lera dos Santos, T Antônio Prince Franzini, E Guimarães Hourneuax de Moura
Journal: Endoscopy (2021)

Aims Bile duct tumors are no curative in most cases. Endoscopic biliary drainage is considered the gold standard for palliative treatment of unresectable and/or inoperable distal malignant distal biliary obstruction (MDBO). This meta-analysis aims to compare plastic stent (PS) versus metal stent (SEMS) in the palliative treatment of MDBO and evaluate which one has the greatest benefit.
Comparison of propranolol, diltiazem, and nifedipine in the treatment of ambulatory ischemia in patients with stable angina. Differential effects on ambulatory ischemia, exercise performance, and anginal symptoms. The ASIS Study Group.
Authors: P HStone, R SGibson, S PGlasser, M ADeWood, J DParker, D TKawanishi, M HCrawford, F CMessineo, T LShook, KRaby
Journal: Circulation (1990)

Episodes of transient myocardial ischemia during ambulatory activities are common in patients with stable coronary artery disease and who are often asymptomatic. Selection of therapy for episodes of asymptomatic ischemia is limited by a lack of direct comparative studies. To determine the most effective monotherapy for patients with stable angina and a high frequency of asymptomatic ischemic episodes, propranolol-LA (mean daily dose, 293 mg), diltiazem-SR (mean daily dose, 350 mg), nifedipine (mean daily dose, 79 mg) were each compared with placebo, each for 2 weeks, in a randomized, double-blinded, crossover trial. Entry criteria were a positive exercise treadmill test during placebo therapy characterized by 1.0 mm or more ST segment depression and angina pectoris, and six or more episodes of transient ST segment depression of 1.0 mm or more on a 48-hour ambulatory electrocardiogram. One hundred ninety-four patients were screened, 63 were eligible and received randomized therapy, of which 56 patients com...
Effects of hypoxia on the closing pressure of the canine systemic arterial circulation.
Authors: J TSylvester, R DGilbert, R JTraystman, SPermutt
Journal: Circulation Research (1981)

We studied the relationships among closing pressure (Pc) and indices of systemic arterial resistance (Ra) and compliance (Ca) during hypoxic hypoxia (HH) and carbon monoxide hypoxia (COH) in anesthetized dogs with cardiac bypass and constant ventilation. Closing pressure was measured as the lowest level to which arterial pressure (Pa) fell after inflow to the arterial bed was reduced suddenly to zero. Since the fall of Pa to Pc could be well-described as a single exponential function of time and since Pc was always greater than outflow (venous) pressure. Ra and CA were determined by applying a vascular waterfall model to the arterial bed. During HH, Pc increased while Ra and Ca decreased. During COH, Pc and Ra decreased, but Ca did not change. The Pc results indicate that during HH, but not COH, a large portion of the systemic arterial bed experienced a marked increase in vasomotor tone, a qualitative difference that would have been missed if Pc had not been measured. The relationship among Pc, Ra, and ...
Chronic Pelvic Pain in Women
Authors: A. Alcock
Journal: BMJ (1926)

CHRONIC PELCVI PAIN" a OMt 609 11 , Jo=M~~~~~~~~~~~~~~~~ tion of a discoid sequestrum with eroded edges.In gum- iiatous periostitis more than one bonie may be affected, as in the following case.CASE VII.A young man developed a brawny fluctuating swelling of the left upper eyelid, ptosis and downward displacement of the eye-
The Importance of Longitudinal Treatment Engagement for Youths in the Juvenile Justice System
Authors: Matthew C. Aalsma, Ally Dir
Journal: JAMA Pediatrics (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Interaction of sequential stimuli applied during the relative refractory period in relation to determination of fibrillation threshold in the canine ventricle.
Authors: JTamargo, BMoe, G KMoe
Journal: Circulation Research (1975)

An ineffective stimulus applied to cardiac tissue within the relative refractory period can alter the response to an immediately subsequent stimulus. We observed three response patterns that can coexist at different sites of stimulation in the same heart. In the first pattern, a stimulus of two to ten times diastolic threshold, applied too early to elicit a propagated response, becomes effective when a stimulus of equal strength is delivered 10 msec earlier. In the second pattern, a stimulus applied just late enough to evoke a response fails to do so when a stimulus of equal strenght precedes it by as much as 30 msec. Finally, in the third pattern, two stimuli, separated by 10 msec, both of which are late enough to be effective when they are given alone, fail to yield a propagated response when they are applied together. These results have a bearing on the use of trains of stimuli to assess the ventricular fibrillation threshold. Possible interpretations are based on the temporal dispersion of recovery fr...
From the authors
Authors: J. Gea, E. Barreiro, C. Sanjuas
Journal: European Respiratory Journal (2005)

Respiratory medicine: what is the diagnosis?To the Editors:Clues of the pressurised metered-dose inhaler in the left shirt pocket and the right upper lobe fibrosis should prompt the reader to consider the unifying diagnosis of allergic bronchopulmonary aspergillosis (fig.1).This 48-yr-old male had difficult-to-control asthma with elevated serum immunoglobulin E levels, presence of aspergillus immunoglobulin E antibodies, and the occurrence of central bronchiectasis, fibrosis and loss of volume in the right upper lobe on computed tomography of the thorax.The common causes of upper lobe fibrosis in the lungs are Tuberculosis, Extrinsic allergic alveolitis, Allergic bronchopulmonary aspergillosis, Radiation, and Sarcoidosis (TEARS).Other causes include ankylosing spondylitis, drugs, silicosis, and Langerhans' cell histiocytosis.The patient responded well to oral corticosteroid therapy and continues to be on maintenance prednisolone 2 yrs following the diagnosis.
Calcium antagonists differently inhibit proliferation of human coronary smooth muscle cells in response to pulsatile stretch and platelet-derived growth factor.
Authors: ZYang, GNoll, T FLüscher
Journal: Circulation (1993)

BACKGROUNDVascular smooth muscle cell proliferation is the key event of coronary artery disease. Mechanical forces, in particular, pulsatile stretch and platelet-derived growth factor, may play an important role.METHODS AND RESULTSVascular smooth muscle cells were cultured from the media of human left descending coronary arteries obtained from organ donors using the explant method. To study effects of pulsatile stretch on vascular smooth muscle cell proliferation, a computer-controlled in vitro pulsatile stretch device was used. Cells were seeded onto Flex I culture plates with deformable membranes and exposed to pulsatile stretch (60 cycles per minute) and/or growth factors. Proliferation of smooth muscle cells was determined by 3H-thymidine incorporation. Pulsatile stretch markedly stimulated 3H-thymidine incorporation of coronary smooth muscle cells (180 +/- 15 to 432 +/- 27 cpm/10(5) cells; P < .05) after 24 hours and increased cell number after 6 days (10.3 +/- 0.7 x 10(4)/mL; P < .05). Platelet-deri...
Height and incidence of cardiovascular disease in male physicians.
Authors: P RHebert, J WRich-Edwards, J EManson, P MRidker, N RCook, G TO'Connor, J EBuring, C HHennekens
Journal: Circulation (1993)

BACKGROUNDAn inverse association between height and risk of coronary heart disease (CHD) has been reported in several case-control and cohort studies, but the reasons for the association remain uncertain. We evaluated this association among 22,071 male physicians, a population homogeneous for high educational attainment and socioeconomic status in adulthood.METHODS AND RESULTSThe study population was comprised of participants in the Physicians' Health Study, a randomized, double-blind, placebo-controlled trial of low-dose aspirin and beta-carotene in the primary prevention of cardiovascular disease and cancer among US male physicians, aged 40 to 84 years, in 1982. Participants were classified into five height categories at study entry, from shortest to tallest, and were followed an average of 60.2 months to determine the incidence of myocardial infarction (MI), stroke, and death from cardiovascular disease. Men in the tallest (> or = 73 in. or 185.4 cm) compared with the shortest (< or = 67 in. or 170.2 c...
Detection and localization of prolonged epicardial electrograms with 64-lead body surface signal-averaged electrocardiography.
Authors: R AFreedman, M SFuller, G MGreenberg, P RErshler, R LLux, T BMcLaughlin, RMenlove, L SGreen, DModdrelle, RKrall
Journal: Circulation (1991)

BACKGROUNDProlonged, fractionated ventricular electrograms often are detectable after myocardial infarction and are a marker for an arrhythmia-prone state. QRS late potentials detected on the body surface with signal-averaged electrocardiography (SAECG) are thought to arise from the diseased tissue that generates prolonged ventricular electrograms and as such are also a marker for arrhythmias. A limitation of the current SAECG technique is that recordings are obtained from only three bipolar lead pairs. Because late potentials probably arise from multiple small sources in the heart, more extensive sampling of the body surface may contribute additional information to the SAECG: The present study investigates the additional sensitivity of SAECG using 64 body surface leads in detecting prolonged epicardial electrograms and examines its use in determining the epicardial location of prolonged electrograms.METHODS AND RESULTSDogs were studied before and 5-10 days after either lateral left ventricular (n = 13) o...
148P Neutrophil to lymphocyte ratio as a prognostic factor in epidermal growth factor receptor-mutant non-small cell lung cancer treated with tyrosine kinase inhibitor: A systematic review and meta-analysis
Authors: R.S. Heriyanto, J. Tandiono, E. Marcella, B. Susanto, S. Chen, F. Wijovi, A. Tancherla, A. Kurniawan
Journal: Journal of Thoracic Oncology (2021)
Diastolic stiffness and myocardial structure in aortic valve disease before and after valve replacement.
Authors: O MHess, MRitter, JSchneider, JGrimm, MTurina, H PKrayenbuehl
Journal: Circulation (1984)

Passive diastolic properties were determined in 10 control patients and 21 patients with aortic valve disease before and 17.5 months after successful valve replacement. Ten patients had severe aortic stenoses (AS), five had combined aortic valve lesions (AS + aortic insufficiency [AI]), and six patients had severe AI. Left ventricular endomyocardial biopsies were obtained before and after surgery in patients with AS, AS + AI, and AI. Simultaneous echocardiographic and high-fidelity pressure measurements were made in all patients, and left ventricular chamber stiffness was calculated from a viscoelastic pressure-circumference relationship and left ventricular myocardial stiffness from a viscoelastic stress-strain relationship. The constant of chamber stiffness, beta', was slightly although not significantly increased in patients with AS (0.27 before and 0.24 after surgery), but was normal in those with AS + AI (0.22 before and 0.17 after surgery) and slightly decreased in those with AI (0.18 before and 0.1...
Central command increases sympathetic nerve activity during spontaneous locomotion in cats.
Authors: GHajduczok, J SHade, A LMark, J LWilliams, R BFelder
Journal: Circulation Research (1991)

A controversial issue in exercise physiology is the relative contribution of central command versus afferent input from contracting muscles and baroreceptors in the regulation of sympathetic nerve activity (SNA) during exercise. Recent studies of exercising humans have suggested that central command increases cutaneous sympathetic sudomotor nerve activity but have challenged the concept that central command contributes importantly to increases in sympathetic vasoconstrictor nerve activity to skin and skeletal muscle. The purpose of this study was to examine the influence of central command on renal SNA and lumbar SNA during spontaneous locomotion in decorticate cats. Unanesthetized decorticate cats that developed locomotion spontaneously or during electrical stimulation of the subthalamic locomotor region were studied in the presence and absence of input from skeletal muscle and baroreceptor afferents. Spontaneous rhythmic locomotion in the unparalyzed state was associated with significant increases in me...
Letter by Potere et al Regarding Article, “Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases C-C Chemokine Receptor Type 7 (CCR7) Expression in Plaque Macrophages”
Authors: Nicola Potere, Stefano Toldo, Antonio Abbate
Journal: Circulation (2019)
Visualization of Ebstein's anomaly of the tricuspid valve by two-dimensional and standard echocardiography.
Authors: MMatsumoto, HMatsuo, SNagata, YHamanaka, TFujita
Journal: Circulation (1976)

Seven patients with Ebstein's anomaly were studied by two-dimensional echocardiography, with and without stop-action technique, and by standard echocardiography. Sagittal two-dimensional echocardiograms visualized a small functional right ventricle and a large atrialized right ventricle. These two parts of the chamber were separated by the anterior tricuspid leaflet and its chordae tendineae. The echocardiograms corresponded to the findings of the right ventriculogram. In horizontal two-dimensional echocardiograms a huge anterior tricuspid leaflet, atrialized right ventricle, and a displaced septal tricuspid leaflet, intervening between the functional right ventricle and the sinus portion of the functional right ventricle, were visualized. The origin of the septal tricuspid leaflet was clearly shown to be abnormal in five cases. The left ventricle was small with distinct clockwise rotation of the interventricular septum. Two-dimensional echocardiography provided information useful in evaluation of the fun...
Pathogenic <i>UBA1</i> variants associated with VEXAS syndrome in Japanese patients with relapsing polychondritis
Authors: Naomi Tsuchida, Yosuke Kunishita, Yuri Uchiyama, Yohei Kirino, Makiko Enaka, Yukie Yamaguchi, Masataka Taguri, Shoji Yamanaka, Kaoru Takase-Minegishi, Ryusuke Yoshimi, Satoshi Fujii, Hideaki Nakajima, Naomichi Matsumoto
Journal: Annals of the Rheumatic Diseases (2021)

To determine clinical and genetic features of individuals with relapsing polychondritis (RP) likely caused by pathogenic somatic variants in ubiquitin-like modifier activating enzyme 1 (UBA1).Fourteen patients with RP who met the Damiani and Levine criteria were recruited (12 men, 2 women; median onset age (IQR) 72.1 years (67.1-78.0)). Sanger sequencing of UBA1 was performed using genomic DNA from peripheral blood leukocytes or bone marrow tissue. Droplet digital PCR (ddPCR) and peptide nucleic acid (PNA)-clamping PCR were used to detect low-prevalence somatic variants. Clinical features of the patients were investigated retrospectively.UBA1 was examined in 13 of the 14 patients; 73% (8/11) of the male patients had somatic UBA1 variants (c.121A>C, c.121A>G or c.122T>C resulting in p.Met41Leu, p.Met41Val or p.Met41Thr, respectively). All the variant-positive patients had systemic symptoms, including a significantly high prevalence of skin lesions. ddPCR detected low prevalence (0.14%) of somatic variant (c.121A>C) in one female patient, which was subsequently confirmed by PNA-clamping PCR.Genetic screening for pathogenic UBA1 variants should be considered in patients with RP, especially male patients with skin lesions. The somatic variant in UBA1 in the female patient is the first to be reported.
The effect of an increase in inotropic state and end-diastolic volume on the pumping ability of the feline left heart.
Authors: GElzinga, NWesterhof
Journal: Circulation Research (1978)

In isolated ejecting cat hearts, the pumping ability of the left heart was described quantitatively by the relationship between mean left ventricular pressure and mean left ventricular output. This relationship was determined by making the heart eject against a series of different loads on a beat-to-beat basis. Left ventricular mean pressure-mean output relationships of control and potentiated beats (at the same end-diastolic pressure) have a common intercept on the output axis but diverge toward the pressure axis. When the mean pressure values of the potentiated beats in a given experiment are multiplied by a single factor, superposition of the two relationships is obtained. A change in left ventricular end-diastolic pressure caused a more parallel shift of the left ventricular mean pressure-mean output relationship. Here, superposition could be obtained by using one multiplication factor for the mean pressure data and one for the mean output data of the relationship found after the change in end-diastol...
Stamps deliver covid tributes
Authors: Alison Shepherd
Journal: BMJ (2021)

Twenty one countries and the UN have between them released 68 postage stamps to mark the sacrifice of healthcare workers and patients during the covid-19 pandemic, a French study has discovered. 1 Led by Bertrand Lefrère of the Public Assistance Hospital of Paris, the research found that Iran was first to post a design last March (pictured), but the rest of the world followed with stamps depicting healthcare workers, patients, and covid safe behaviours such as social distancing in French Polynesia.