tbuckley/cabot-search huggingface dataset:
Abstract 16747: Rapidly Lethal Dilated Cardiomyopathy Secondary To Generalized Arterial Calcification Of Infancy
Authors: Laura C. Pantoja, Maria del Mar Rodriguez Vazquez del Rey, Maria Teresa Medina Cano, Alejandro Carrero Castaño, Lorenzo Monserrat, Francesca Perin
Journal: Circulation (2021)

Case Presentation: A previously healthy 3-month-old infant presented with cardiorespiratory arrest, from which she was successfully resuscitated. A dilated cardiomyopathy with severely depressed systolic function was diagnosed. ECG showed high voltage QRS complexes and generalized alteration of repolarization. In the following 12 hours, she suffered 2 other cardiac arrests, recuperated with defibrillation. Hemodinamic stability was achieved but brain death was diagnosed 36 hours after the onset of symptoms. Autopsy showed striking calcification of the right and left coronary arteries, with narrowing of the arterial lumen, causing extensive subendocardial infarction. Calcification also affected the aorta, pulmonary arteries, thyroid, kidney and other splanchnic arteries. Generalized arterial calcification of infancy (GACI) was diagnosed and a genetic study found two biallelic variants in ABCC6 gene: p.Arg1114Cys and p.Trp38Ser, both previously described in elastic pseudoxanthoma (PXE), but not in GACI. Genotyping of the healthy parents confirmed genetic segregation with biallelic variants. Discussion: GACI is an extremely rare genetic disease characterized by widespread arterial calcification and narrowing of large and medium-sized vessels. The usual clinical presentation is heart failure in fetal life or in the first months of infancy. In most cases it is lethal, with death occurring within a few hours or days after the onset of symptoms, although clinical involvement is highly variable and cases with long survival have been described. GACI is an autosomal recessive disease secondary to biallelic variants in the ENPP1 gene (67% of cases) and in the ABCC6 gene (9%). The variants found in our patient had not been previously described in GACI, just in PXE, a much milder disease with usually normal lifespan. This case confirms that both entities reflect two extremes of a clinical spectrum of ectopic calcification instead of two different disorders. The aim of presenting this case is to remind clinicians of this rare etiology in neonates or infants with dilated cardiomyopathy. In case of death, autopsy should always be requested. When this condition is diagnosed, genetic study will be positive in 75% of cases, allowing prenatal counseling.
In rotator cuff disorder, progressive exercise vs. physiotherapy advice, with or without corticosteroid injection, did not differ at 12 mo
Authors: Dinesh Kumbhare
Journal: Annals of Internal Medicine (2021)

Source Citation Hopewell S, Keene DJ, Marian IR, et al. Progressive exercise compared with best practice advice, with or without corticosteroid injection, for the treatment of patients with rotator cuff disorders (GRASP): a multicentre, pragmatic, 2 x 2 factorial, randomised controlled trial. Lancet. 2021;398:416-28. 34265255
Estimated Effectiveness of COVID-19 Messenger RNA Vaccination Against SARS-CoV-2 Infection Among Older Male Veterans Health Administration Enrollees, January to September 2021
Authors: Yinong Young-Xu, Gabrielle M. Zwain, Ethan I. Powell, Jeremy Smith
Journal: JAMA Network Open (2021)

This case-control study examines estimated COVID-19 messenger RNA vaccination effectiveness against SARS-CoV-2 infection from January to September 2021 among fully vaccinated male veterans aged 65 years or older.
HIV-associated talaromycosis: Does timing of antiretroviral therapy matter?
Authors: Yuanyuan Qin, Yihong Zhou, Songtao Liu, Yanqiu Lu, Min Liu, Jing Yuan, Jingmin Nie, Jing Ouyang, Hao Wu, Yingmei Qin, Zhongsheng Jiang, Guoqiang Zhou, Qun Tian, Ke Lan, Yang Zhou, Xinping Yang, Kaiyin He, Jun Liu, Vijay Harypursat, Yaokai Chen
Journal: Journal of Infection (2021)

<h2>Abstract</h2><h3>Objectives</h3> <b>:</b> No current academic data is available with respect to the optimal timing to initiate antiretroviral therapy (ART) in HIV-positive patients with talaromycosis. Our study aimed to evaluate the optimal timing of ART initiation for patients presenting with AIDS-related talaromycosis. <h3>Methods</h3> <b>:</b> In this prospective, randomized, open-label multicenter trial, 228 patients from 15 hospitals in China were randomly assigned to an early ART group (initiation of ART within 2 weeks after randomization) and a deferred ART group (initiation of ART 2 weeks after randomization). The primary endpoint was all-cause mortality during the 48 weeks after randomization. <h3>Results</h3> <b>:</b> We observed a significant difference in mortality between the early ART group and the deferred ART group (2.2% vs. 8.9%, 95%CI: -0.15 to 14.05, <i>p</i> = 0.049). The composite outcome of AIDS-defining events or death in the early ART group was found to be lower than that in the deferred ART group (3.3% vs. 14.9%; 95%CI: 2.93 to 19.23, <i>p</i> = 0.008). <h3>Conclusions</h3> <b>:</b> The prognosis of HIV-infected patients with talaromycosis in the early ART group was more favorable than that of patients in the deferred ART group. These results demonstrate that early ART initiation should be considered in HIV-infected patients with talaromycosis .
The burden of respiratory syncytial virus in children under 5 years of age in Norway
Authors: Lise Beier Havdal, Håkon Bøås, Terese Bekkevold, Anne-Marte Bakken Kran, Astrid Elisabeth Rojahn, Ketil Størdal, Sara Debes, Henrik Døllner, Svein Arne Nordbø, Bjørn Barstad, Elisebet Haarr, Liliana Vázquez Fernández, Britt Nakstad, Christopher Inchley, Elmira Flem
Journal: Journal of Infection (2021)

To estimate age-specific incidence of medically attended respiratory syncytial virus (RSV) infections in hospitalised Norwegian children and describe disease epidemiology.Active prospective hospital surveillance for RSV in children <59 months of age was conducted during 2015-2018. All febrile children 12-59 months of age were enrolled, whereas children <12 months were enrolled based on respiratory symptoms regardless of fever. Surveillance data were linked to national registry data to estimate the clinical burden of RSV.Of the children enrolled, 1096 (40%) were infected with RSV. The highest incidence rates were found in children 1 month of age, with a peak incidence of 43 per 1000 during the 2016-2017 season. In comparison, children 24-59 months of age had an infection rate of 1.4 per 1000 during the same winter season. The peak season was during the 2016-2017 winter, with an incidence rate of 6.0 per 1000 children 0-59 months of age. In the study population a total of 168 (15%) of the infected children had pre-existing medical conditions predisposing for more severe disease. High infection rates were found in this population.Children with comorbidities showed high hospital contact rates, but the majority of children in need of medical attention associated with RSV infection were previously healthy.
Errors in Table 3 Footnotes
Journal: JAMA Network Open (2021)

Soudabeh Fazeli, MD, MPH; Bradley S. Snyder, MS; Ilana F. Gareen, PhD, MPH; Constance D. Lehman, MD, PhD; Seema A. Khan, MD; Justin Romanoff, MA; Constantine A. Gatsonis, PhD; Kathy D. Miller, MD; Joseph A. Sparano, MD; Christopher E. Comstock, MD; Lynne I. Wagner, PhD; Ruth C. Carlos, MD, MS
The exercise-induced long noncoding RNA <i>CYTOR</i> promotes fast-twitch myogenesis in aging
Authors: Martin Wohlwend, Pirkka-Pekka Laurila, Kristine Williams, Mario Romani, Tanes Lima, Pattamaprapanont Pattawaran, Giorgia Benegiamo, Minna Salonen, Bernard L. Schneider, Jari Lahti, Johan G. Eriksson, Romain Barrès, Ulrik Wisløff, José B. N. Moreira, Johan Auwerx
Journal: Science Translational Medicine (2021)

Exercise activates the lncRNA Cytor , which reestablishes fast-twitch muscle fibers in aged skeletal muscle, improving morphology and function.
Novel low‐avidity glypican‐3 specific CARTs resist exhaustion and mediate durable antitumor effects against HCC
Authors: Leidy D. Caraballo Galva, Xiaotao Jiang, Mohamed S. Hussein, Huajun Zhang, Rui Mao, Pierce Brody, Yibing Peng, Aiwu Ruth He, Mercy Kehinde‐Ige, Ramses Sadek, Xiangguo Qiu, Huidong Shi, Yukai He
Journal: Hepatology (2021)

Chimeric antigen receptor engineered T cells (CARTs) for HCC and other solid tumors are not as effective as they are for blood cancers. CARTs may lose function inside tumors due to persistent antigen engagement. The aims of this study are to develop low-affinity monoclonal antibodies (mAbs) and low-avidity CARTs for HCC and to test the hypothesis that low-avidity CARTs can resist exhaustion and maintain functions in solid tumors, generating durable antitumor effects.New human glypican-3 (hGPC3) mAbs were developed from immunized mice. We obtained three hGPC3-specific mAbs that stained HCC tumors, but not the adjacent normal liver tissues. One of them, 8F8, bound an epitope close to that of GC33, the frequently used high-affinity mAb, but with approximately 17-fold lower affinity. We then compared the 8F8 CARTs to GC33 CARTs for their in vitro function and in vivo antitumor effects. In vitro, low-avidity 8F8 CARTs killed both hGPC3high and hGPC3low HCC tumor cells to the same extent as high-avidity GC33 CARTs. 8F8 CARTs expanded and persisted to a greater extent than GC33 CARTs, resulting in durable responses against HCC xenografts. Importantly, compared with GC33 CARTs, there were 5-fold more of 8F8-BBz CARTs in the tumor mass for a longer period of time. Remarkably, the tumor-infiltrating 8F8 CARTs were less exhausted and apoptotic, and more functional than GC33 CARTs.The low-avidity 8F8-BBz CART resists exhaustion and apoptosis inside tumor lesions, demonstrating a greater therapeutic potential than high-avidity CARTs.
Response to: ‘Validation of generalized drug‐related rash diagnoses using International Classification of Diseases 9 <sup>th</sup> and 10 <sup>th</sup> Revision codes’: reply from the authors
Authors: Michael Goldenberg, Somashekar G. Krishna, Nima Milani‐Nejad, John C. Trinidad, Benjamin H. Kaffenberger
Journal: British Journal of Dermatology (2021)
Accelerated blood clearance and hypersensitivity by PEGylated liposomes containing TLR agonists
Authors: Camilla Stavnsbjerg, Esben Christensen, Rasmus Münter, Jonas R. Henriksen, Matthias Fach, Ladan Parhamifar, Camilla Christensen, Andreas Kjaer, Anders E. Hansen, Thomas L. Andresen
Journal: Journal of Controlled Release (2021)
A preliminary study of the innate immune memory of Kupffer cells induced by PEGylated nanoemulsions
Authors: Mengyang Liu, Yuqing Su, Meng Chen, Jia Wang, Min Liu, Yueying Dai, Chunling Wang, Xiang Luo, Chaoyang Lai, Mingqi Liu, Junqiang Ding, Cong Li, Yawei Hu, Xueying Tang, Xinrong Liu, Yihui Deng, Yanzhi Song
Journal: Journal of Controlled Release (2021)
Phase 2 Study of Carfilzomib in Combination with Induction Chemotherapy in Children with Relapsed or Refractory (R/R) Acute Lymphoblastic Leukemia (ALL)
Authors: David S. Ziegler, Van Huynh, Michael J. Burke, Lia Gore, Franco Locatelli, Maureen M. O'Brien, Christopher Kim, Mihaela Obreja, Christopher L. Morris, André Baruchel
Journal: Blood (2021)
More Pediatric Data for First Cell-Derived Influenza Vaccine
Authors: Anita Slomski
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 11312: Activation of Citizen Responders to Out-of-Hospital Cardiac Arrest: Temporal Changes During the COVID-19 Outbreak in Denmark 2020
Authors: Mads Christian Tofte Gregers, Linn Andelius, Carolina Malta Hansen, Astrid Rolin Kragh, Christian Torp-Pedersen, Helle Collatz Christensen, Julie Kjoelbye, Ulla Væggemose, Erika Frischknecht Christensen, Fredrik Folke
Journal: Circulation (2021)

Introduction: Multiple citizen responder (CR) programs worldwide which dispatch laypersons to out-of-hospital cardiac arrest (OHCA) to perform cardiopulmonary resuscitation (CPR) and use of automated external defibrillators (AEDs) were affected by the COVID-19 outbreak in 2020, but little is known about how the pandemic affected CR activation and initiation of bystander CPR and defibrillation. In Denmark, the CR program continued to run during lockdown but with the recommendation to perform chest-compression-only CPR in contrast to standard CPR including ventilations. We hypothesized that bystander interventions as CPR and AED usage decreased during the first COVID-19 lockdown in two regions of Denmark in the spring of 2020. Methods: All OHCAs from January 1, 2020 to June 30, 2020 with CR activation from the Danish Cardiac Arrest Registry and the National Citizen Responder database. Bystander CPR, AED usage, and CRs’ alarm acceptance rate during the national lockdown from March 11, 2020 to April 20, 2020 were compared with the non-lockdown period from January 1, 2020 to March 10, 2020 and from April 21 to June 30, 2020. Results: A total of 6,120 CRs were alerted in 443 (23/100.000 inhabitants) cases of presumed OHCA of which 256 (58%) were confirmed cardiac arrests. Bystander CPR remained equally high in the lockdown period compared with non-lockdown period (99% vs. 92%, p=0.07). Likewise, there was no change in bystander defibrillation (9% vs. 14%, p=0.4). There was a slight increase in the number of CRs who accepted an alarm (7 per alarm, IQR 4) during lockdown compared with non-lockdown period (6 per alarm, IQR 4), p=0.0001. The proportion of patients achieving return of spontaneous circulation at hospital arrival was also unchanged (lockdown 23% vs non-lockdown 23%, p=1.0) (Table 1). Conclusion: Bystander initiated resuscitation rates did not change during the first COVID-19 lockdown in Denmark for OHCAs where CRs were activated through a smartphone app.
Loneliness and Major Depressive Disorder in the Elderly with a History of Suicidal Ideation or Attempt: A Comment on “Therapist-Guided Internet-Based Treatments for Loneliness” by Käll et al.
Authors: Hiu Ching Siu, Shwu-Hua Lee, Josephine Sheron Au, Alfred Pak-Kwan Lo, Chih-Mao Huang, Yun-Fang Tsai, Tatia Mei-Chun Lee, Ho-Ling Liu, Chemin Lin, Chui-De Chiu
Journal: Psychotherapy and Psychosomatics (2021)
Exosomes derived from differentiated human ADMSC with the Schwann cell phenotype modulate peripheral nerve-related cellular functions
Authors: Bo Liu, Yunfan Kong, Wen Shi, Mitchell Kuss, Ke Liao, Guoku Hu, Peng Xiao, Jagadesan Sankarasubramanian, Chittibabu Guda, Xinglong Wang, Yuguo Lei, Bin Duan
Journal: Bioactive Materials (2021)

Peripheral nerve regeneration remains a significant clinical challenge due to the unsatisfactory functional recovery and public health burden. Exosomes, especially those derived from mesenchymal stem cells (MSCs), are promising as potential cell-free therapeutics and gene therapy vehicles for promoting neural regeneration. In this study, we reported the differentiation of human adipose derived MSCs (hADMSCs) towards the Schwann cell (SC) phenotype (hADMSC-SCs) and then isolated exosomes from hADMSCs with and without differentiation (i.e., dExo vs uExo). We assessed and compared the effects of uExo and dExo on antioxidative, angiogenic, anti-inflammatory, and axon growth promoting properties by using various peripheral nerve-related cells. Our results demonstrated that hADMSC-SCs secreted more neurotrophic factors and other growth factors, compared to hADMSCs without differentiation. The dExo isolated from hADMSC-SCs protected rat SCs from oxidative stress and enhanced HUVEC migration and angiogenesis. Compared to uExo, dExo also had improved performances in downregulating pro-inflammatory gene expressions and cytokine secretions and promoting axonal growth of sensory neurons differentiated from human induced pluripotent stem cells. Furthermore, microRNA (miRNA) sequencing analysis revealed that exosomes and their parent cells shared some similarities in their miRNA profiles and exosomes displayed a distinct miRNA signature. Many more miRNAs were identified in dExo than in uExo. Several upregulated miRNAs, like miRNA-132-3p and miRNA-199b-5p, were highly related to neuroprotection, anti-inflammation, and angiogenesis. The dExo can effectively modulate various peripheral nerve-related cellular functions and is promising for cell-free biological therapeutics to enhance neural regeneration.
Commentary
Authors: Yuichi Mori
Journal: Endoscopy (2021)

The recent explosion of artificial intelligence (AI) technologies gives us cause for optimism about the adoption of AI in colonoscopy. The use of AI for polyp detection is reported to increase the adenoma detection rate by roughly 50 % [1]. However, to benefit from AI improvements in polyp detection, the endoscopist must successfully expose the mucosal surface. McGill et al. have tackled this operator-dependent barrier by using an AI-based 3-dimensional reconstruction model to identify blind spots during colonoscopy [2]. This will lead to significant clinical gains, because endoscopists will potentially improve mucosal surface inspection in real time using this technology and, after a colonoscopy, will have feedback about the proportion of the mucosa that was actually exposed. Another author group in China has shown actual clinical benefits from using a similar technology [3]. Revolution in colonoscopy never ceases!
Abstract Supplement ACR Convergence 2021
Authors: Alexandrine Mahoudeau, Céline Anquetil, Nozomu Tawara, Hossein Khademian, Damien Amelin, Yves Allenbach, Olivier Benveniste
Journal: Arthritis & Rheumatology (2021)

For a searchable version of these abstracts, please visit www.acrabstracts.org.
Shared decision-making in urology and female pelvic floor medicine and reconstructive surgery
Authors: David A. Ossin, Emily C. Carter, Rufus Cartwright, Philippe D. Violette, Shilpa Iyer, Geraldine T. Klein, Sangeeta Senapati, Zachary Klaassen, Sylvia M. Botros
Journal: Nature Reviews Urology (2021)
Multicenter Randomized Clinical Trial of a Mailed Outreach Strategy for Hepatocellular Carcinoma Surveillance
Authors: Amit G Singal, Sarah Reddy, Himani Radadiya Aka Patel, Deyaun Villarreal, Aisha Khan, Yan Liu, Vanessa Cerda, Nicole E Rich, Caitlin C Murphy, Jasmin A Tiro, Jennifer R Kramer, Ruben Hernaez
Journal: Clinical Gastroenterology and Hepatology (2021)
MBG/ PGA-PCL composite scaffolds provide highly tunable degradation and osteogenic features
Authors: Jiangfeng Li, Chunyi Wang, Guoxing Gao, Xing Yin, Ximing Pu, Bing Shi, Yang Liu, Zhongbing Huang, Juan Wang, Jingtao Li, Guangfu Yin
Journal: Bioactive Materials (2021)

It remains a challenge to achieve satisfactory balance between biodegradability and osteogenic capacity in biosynthetic bone grafts. In this study, we aimed to address this challenge by incorporating mesoporous bioactive glass (MBG) into poly(caprolactone-co-glycolide) (PGA-PCL) at gradient ratios. MBG/PGA-PCL (PGC/M) scaffolds with MBG incorporation ratio at 0, 10%, 25% and 40% (PGC/M0-40) were synthesized using a modified solvent casting-particulate leaching method, and their physiochemical and biological properties were comprehensively evaluated. PGC/M scaffolds exhibited highly perforated porous structure with a large-pore size of 300-450 μm, with ordered MBGs of around 6.0 nm mesopores size uniformly dispersed. The increase in MBG incorporation ratio significantly improved the scaffold surface hydrophilicity, apatite-formation ability and pH stability, increased the weight loss rate while insignificantly influenced the molecular chains degradation of PGA-PCL component, and facilitated the attachment, spreading, viability and proliferation of rat bone marrow stromal cells (rBMSCs) on scaffolds. Moreover, rBMSCs cultured on PGC/M10-40 scaffolds demonstrated enhanced ALP activity and osteogenesis-related gene expression in a MBG dose-dependent manner as compared with those cultured on PGC/M0 scaffolds. When implanted to the rat cranial bone defect, PGC/M25 and PGC/M40 scaffolds induced significantly better bone repair as compared to PGC/M0 and PGC/M10 scaffolds. Besides, the biodegradability of PGC/M scaffolds correlated with the MBG incorporation ratio. These data suggested this novel PGC/M scaffolds as promising bone repair biomaterial with highly tunable hydrophilicity, bioactivity, cytocompatibility, osteogenic activity as well as biodegradability.
Stabilizing Ryanodine Receptors Improves Left Ventricular Function in Juvenile Dogs With Duchenne Muscular Dystrophy
Authors: Olivier Cazorla, Inès Barthélémy, Jin Bo Su, Albano C. Meli, Valérie Chetboul, Valérie Scheuermann, Vassiliky Gouni, Camille Anglerot, Sylvain Richard, Stéphane Blot, Bijan Ghaleh, Alain Lacampagne
Journal: Journal of the American College of Cardiology (2021)
Genetic analysis of praziquantel response in schistosome parasites implicates a transient receptor potential channel
Authors: Winka Le Clec’h, Frédéric D. Chevalier, Ana Carolina A. Mattos, Amanda Strickland, Robbie Diaz, Marina McDew-White, Claudia M. Rohr, Safari Kinung’hi, Fiona Allan, Bonnie L. Webster, Joanne P. Webster, Aidan M. Emery, David Rollinson, Amadou Garba Djirmay, Khalid M. Al Mashikhi, Salem Al Yafae, Mohamed A. Idris, Hélène Moné, Gabriel Mouahid, Philip LoVerde, Jonathan S. Marchant, Timothy J. C. Anderson
Journal: Science Translational Medicine (2021)

A transient receptor potential channel in Schistosoma mansoni determines variation in praziquantel response.