tbuckley/cabot-search huggingface dataset:
Errata
Authors: ; Simpson, M Eng
Journal: BMJ (1903)

Cinator's" remarks and the editorial comments thereon in the BRITISH MEDICAL, JOURNTAL of Juno 27tll, page 126: (I) Three weeks since I vaccinated a gentlemiian wlho was deeply pitted by small-pox in infancyoVer sixty yeals ago.The result was four perfectly normal vaccinatiou vesicles, albsolutely indistinguishable from the vesicles of primrary vaccillation of a persou wlho had not lhad small-pox.(2) About the sanme tiniie I revaccinia,ted a womiian about 55, wlo Illany years ago had a mlild attack of smiiall-pox wlhilst nursing her baby with a severe attack.She bore isolated marks of the attack.She is caretaker of the small-pox isolation hospital here, and the result was tlle production of four miodified vesicles, such1 as cominmonly appear in the mnajority of revaccinations in primlarily well-vaccinated persons.(3) In tlle small- pox epidemic her-e in 1894, out of a total of 830 persons attacked witl small-pox, 2 had beeni vaccinated once and also had a previous attack of small-pox, and 2 otliers were attacked wlio hlad lad small-pox befole but had never been vaccinated.(4) In ani epidemic of small-pox neal- Ihere in I870-1, Ivaccinated a large number of persons living in smliall lhouses wlhere there was already a case of sinall-pox.In a few cases-!cannot remeimiber the exact number, but think it was about three- small-pox attacked tlhe persons vaccinated shortly after vaccination.Tle small-pox and the vacciniation ran their course concurrently, but the latter muclh quickiel than the former, and in eaclh case the course of the sIiall-p)ox a,s suddenly and powerfully arrested wlhen the vaccination reac led a certain stage in its progress.]).. P. O'CONNEL,L, M.D. (Stilloirgan Castle, Stillorgan, co.Dublin) writes:Probably the following, foi' wlichl I vouchl, may be suclh as "Vaccinator" requires.V-accination was very satisfactorily done in infancy.Small- pox was contracted at the age of 12 to 13 years.The patienlt distinctly remembered being sick aud the nature of the malady, as well as being isolated while sick.It left a. clharacteristic "pit" just above the left eyebrow aiid anotlher hiiglher up on the forelhead.Thlere were four or five marks on time back wlhiclh I also carefully inspected.At the age of 29 years I vaccinated this patient in two places.Botlh insertions took well and ran a niormiial courLse.This is the only case of the kind I lhave met in thirt.-oneyears' pr-actice.DIi. J. H. STACY (Pu1:)blic Vaccina-tor for the City of Norwiel) writes: Last Februarv t%velveinontlh I vaccinated a womian aged 48 whlo was terribly marked with the effects of small-pox.Slie lhad not been vaccinatedpreviously.having contracted small-pox wlien slhe Was 4 years old.The result was fou1-perfectly-formed vesicles, as perfect as seen in primalry infantile vaccination.
More acute myocardial infarctions during spring and a higher mortality dependent on climate in Germany: Results of the MITRA-registry Anselm K. Gitt, Steffen Schenider, Klaus Bucher, Harm Wienbergen, Tobias Heer, Martin Gottwik, Jochen Senges, Rudolf Schiele. Herzzentrum Ludwigshafen, Ludwigshafen, Germany, Deutscher Wetterdienst, Freiburg, Germany
Journal: Journal of the American College of Cardiology (2001)
Preliminary studies on the use of 3,5-diiodothyropropionic acid, a thyroid hormone analog, in the treatment of congestive heart failure Eugene Morkin, Jr., Gregory Pennock, Peter H. Spooner, Joseph J. Bahl, Katherine Underhill Fox, Steven Goldman. Southern Arizona Veterans Administration Health Care System, Department of Cardiology, Tucson, AZ, University of Arizona, Sarver Heart Center, Tucson, AZ
Journal: Journal of the American College of Cardiology (2001)
Contemporary real-world evidence in unresectable HCC (uHCC) patients treated with regorafenib in Taiwan: Interim results from the observational REFINE study.
Authors: Shi-Ming Lin, Chih-Hung Hsu, Long-Bin Jeng, Yih-Jyh Lin, Ming-Yang Lee, Teng-Yu Lee, Yi-Hsiang Huang
Journal: Journal of Clinical Oncology (2022)

402 Background: The phase 3 RESORCE trial showed that regorafenib improved overall survival compared to placebo in uHCC patients (pts) who progressed on sorafenib. The characteristics of real-world pts are more diverse than those included in clinical trials. The global observational REFINE study was designed to evaluate the safety and effectiveness of regorafenib in pts with uHCC in a real-world setting. Methods: REFINE is an ongoing observational study of pts with uHCC who were treated with regorafenib in routine practice. The primary end point includes to assess treatment-emergent adverse events (TEAEs; NCI-CTCAE v4.03). Secondary endpoints include overall survival, progression-free survival, and tumor response. Tumor response and progression are assessed per investigator according to local standard. A planned interim analysis of 1008 pts in the global cohort has been reported (Lim, ILCA 2021). We describe interim results in pts from Taiwan. Results: A total of 137 pts were enrolled and 136 were valid for safety analysis (80% male). At study entry, median age was 65.5 years (Q1-Q3, 60-72); 51.5% pts had an ECOG PS 0 and 24.3% and 12.5% had an ECOG PS of 1 and, respectively (missing 11.8%); proportion of pts classified as Child–Pugh A/B/C were 46.3%/10.3%/0.7% (missing/not evaluable: 40.4%/2.2%). The initial daily regorafenib dose was 160 mg in 8% of pts and 120 mg/80 mg in 9%/78%; 5.1% started at 40 mg. 83.1% pts received regorafenib as a second line agent and 15.4% pts as third line or beyond. 132 pts had prior sorafenib treatment with last daily dose being 400mg in 53.8% of patients; 9 patients (6.6%) had received an immune checkpoint inhibitor. The most frequent TEAEs are shown (Table). Effectiveness results will be presented. Conclusions: The characteristics of real-world pts from Taiwan not only differ from those in the RESORCE trial but also from the global REFINE cohort, reflecting variation across countries. A higher proportion of patients from Taiwan initiated regorafenib at a lower dose. Clinical trial information: NCT03289273. [Table: see text]
Correction: Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy
Authors: Carmela Passaro, Quazim Alayo, Isabel DeLaura, John McNulty, Korneel Grauwet, Hirotaka Ito, Vivek Bhaskaran, Marco Mineo, Sean E. Lawler, Khalid Shah, Maria C. Speranza, William Goins, Eric McLaughlin, Soledad Fernandez, David A. Reardon, Gordon J. Freeman, E. Antonio Chiocca, Hiroshi Nakashima
Journal: Clinical Cancer Research (2020)
Wellsprings
Authors: George N. Braman
Journal: Annals of Internal Medicine (2002)

Ad Libitum21 May 2002WellspringsGeorge N. Braman, MDGeorge N. Braman, MDBronx, NY 10471Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-10-200205210-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail “Whole capes caked off in slices.I felt my standpoint shakenIn the universal crisis …”—“One Step Backward Taken”Robert FrostWellsprings... Author, Article, and Disclosure InformationAffiliations: Bronx, NY 10471Current Author Address: George N. Braman, MD, 6142 Delafield Avenue, Bronx, NY 10471. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 21 May 2002Volume 136, Issue 10Page: 778KeywordsHeart rateMortalityVertigo ePublished: 21 May 2002 Issue Published: 21 May 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Ventricular Fibrosis Making Waves in ST-Segment Elevation
Authors: Zhuo-Yu An, Wen-Biao Chen
Journal: JAMA Internal Medicine (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
GLANDULAR EXTRACT.
Authors: ISAAC OTT
Journal: JAMA (1898)

Glandular physiology in its widespread ramifications has revolutionized many parts of physiology and pathology. It is only in its infancy and its maze of metabolic changes holds many facts to be discovered. The secretion of the ductless glands opens up new avenues of investigation, which will enrich the science of physiology and the practical application of these facts in therapeutics. We have a silent and hitherto unsuspected secretion going on which plays a most important and unknown part in our economy. Very potent remedies are the ductless glands, where but a few thousandths of a grain of a gland like the pituitary greatly elevates the arterial tension. I have made over one hundred experiments upon the lower animals with the various extracts obtained from Armour &amp; Co. of Chicago. The experiments upon the reflexes were made upon frogs, those on pulse pressure, respiration and temperature upon rabbits. The results were
Ultrasonography for diagnosis of orbital tumors
Authors: J. G. Dakters
Journal: JAMA (1968)

The diagnosis of intra-orbital tumors is frequently difficult, and sometimes, in spite of all investigative attempts, the cause of unilateral ocular proptosis is not determined. Also, in cases where the presence of a tumor is strongly suspected, it is occasionally difficult to learn the orbital location of the neoplasm for planning of surgical approach. Ultrasonography of the orbit has been useful for these purposes, and reaching the decision to perform surgical removal is thus simplified. Ultrasonography of the orbit is easily performed and is harmless when done properly.
The Roles of RNA Helicases in DNA Damage Repair and Tumorigenesis Reveal Precision Therapeutic Strategies
Authors: Jinru Xie, Ming Wen, Jiao Zhang, Zheng Wang, Meng Wang, Yanfang Qiu, Wenchao Zhao, Fang Zhu, Mianfeng Yao, Zhuoxian Rong, Wenfeng Hu, Qian Pei, Xiaoxiang Sun, Jinchen Li, Zhiyong Mao, Lun-Quan Sun, Rong Tan
Journal: Cancer Research (2022)

DEAD-box RNA helicases belong to a large group of RNA-processing factors and play vital roles unwinding RNA helices and in ribosomal RNA biogenesis. Emerging evidence indicates that RNA helicases are associated with genome stability, yet the mechanisms behind this association remain poorly understood. In this study, we performed a comprehensive analysis of RNA helicases using multiplatform proteogenomic databases. More than 50% (28/49) of detected RNA helicases were highly expressed in multiple tumor tissues, and more than 60% (17/28) of tumor-associated members were directly involved in DNA damage repair (DDR). Analysis of repair dynamics revealed that these RNA helicases are engaged in an extensively broad range of DDR pathways. Among these factors is DDX21, which was prominently upregulated in colorectal cancer. The high expression of DDX21 gave rise to frequent chromosome exchange and increased genome fragmentation. Mechanistically, aberrantly high expression of DDX21 triggered inappropriate repair processes by delaying homologous recombination repair and increasing replication stress, leading to genome instability and tumorigenesis. Treatment with distinct chemotherapeutic drugs caused higher lethality to cancer cells with genome fragility induced by DDX21, providing a perspective for treatment of tumors with high DDX21 expression. This study revealed the role of RNA helicases in DNA damage and their associations with cancer, which could expand therapeutic strategies and improve precision treatments for cancer patients with high expression of RNA helicases.The involvement of the majority of tumor-associated RNA helicases in the DNA damage repair process suggests a new mechanism of tumorigenesis and offers potential alternative therapeutic strategies for cancer.
TCT-336 Deferral Versus Performance of Coronary Intervention Based on Coronary Pressure-derived Fractional Flow Reserve: Systematic Review and Meta-analysis
Authors: Bruno R. Nascimento, Ana Flavia L Belfort, Gabriel T. Pereira, Antonio Luiz P Ribeiro, Guilherme Rafael S Athayde
Journal: Journal of the American College of Cardiology (2014)
New and Nonofficial Remedies
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Longitudinal immune profiling reveals dominant epitopes mediating long-term humoral immunity in COVID-19–convalescent individuals
Authors: Min Li, Jiaojiao Liu, Renfei Lu, Yuchao Zhang, Meng Du, Man Xing, Zhenchuan Wu, Xiangyin Kong, Yufei Zhu, Xianchao Zhou, Landian Hu, Chiyu Zhang, Dongming Zhou, Xia Jin
Journal: Journal of Allergy and Clinical Immunology (2022)
Correction to Lancet Infect Dis 2021; online Feb 3. https://doi.org/10.1016/S1473-3099(21)00043-8
Journal: The Lancet Infectious Diseases (2021)

this Correspondence, the second sentence of the third paragraph should be "As of the end of January, 2021, the spread of N501Y, B.1.1.7 variants has been detected in SARS-CoV-2 isolate genomes from nearly 60 additional countries using CovMT (appendix)."This correction has been made to the online version as of March 1, 2021, and will be made to the printed version.
I'D RATHER BE FAMOUS
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aortic stenosis with poor ventricular function: Aortic valve pliability at rest predicts results of dobutamine testing Chi-Ming Chow, Robert A. Levine, Mark D. Handschumacher, Emmanuel Messas, Micha S. Feinberg, Ehud Schwammenthal. Massachusetts General Hospital, Boston, MA, Sheba Medical Center, Tel Hashomer, Israel
Journal: Journal of the American College of Cardiology (2001)
BOOK REVIEW
Authors: M. L. LEVITT
Journal: JNCI Journal of the National Cancer Institute (1994)

BOOK REVIEW Lung Cancer Jack A. Roth , James D. Cox , Waun Ki Hong , eds. Boston : Blackwell Sci. Publ. , 1993 . 401 pp., illus. $74.95. ISBN 0-86542-282-6 MARK L. LEVITT, M.D., PH.D. MARK L. LEVITT, M.D., PH.D. University of Pittsburgh, Pittsburgh Cancer Institute, Veterans Administration Hospital, University Drive CPittsburgh, PA 15240 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 9, 4 May 1994, Pages 726–727, https://doi.org/10.1093/jnci/86.9.726 Published: 04 May 1994
Long-term exposure to low ambient air pollution concentrations and mortality among 28 million people: results from seven large European cohorts within the ELAPSE project
Authors: Massimo Stafoggia, Bente Oftedal, Jie Chen, Sophia Rodopoulou, Matteo Renzi, Richard W Atkinson, Mariska Bauwelinck, Jochem O Klompmaker, Amar Mehta, Danielle Vienneau, Zorana J Andersen, Tom Bellander, Jørgen Brandt, Giulia Cesaroni, Kees de Hoogh, Daniela Fecht, John Gulliver, Ole Hertel, Barbara Hoffmann, Ulla A Hvidtfeldt, Karl-Heinz Jöckel, Jeanette T Jørgensen, Klea Katsouyanni, Matthias Ketzel, Doris Tove Kristoffersen, Anton Lager, Karin Leander, Shuo Liu, Petter L S Ljungman, Gabriele Nagel, Göran Pershagen, Annette Peters, Ole Raaschou-Nielsen, Debora Rizzuto, Sara Schramm, Per E Schwarze, Gianluca Severi, Torben Sigsgaard, Maciek Strak, Yvonne T van der Schouw, Monique Verschuren, Gudrun Weinmayr, Kathrin Wolf, Emanuel Zitt, Evangelia Samoli, Francesco Forastiere, Bert Brunekreef, Gerard Hoek, Nicole A H Janssen
Journal: The Lancet Planetary Health (2022)
The Authors Reply:
Authors: Thomas Emil Christensen, Lia Evi Bang, Lene Holmvang, Dorthe Charlotte Skovgaard, Ditte Bang Oturai, Helle Søholm, Jakob Hartvig Thomsen, Hedvig Bille Andersson, Adam Ali Ghotbi, Nikolaj Ihlemann, Andreas Kjaer, Philip Hasbak
Journal: JACC. Cardiovascular imaging (2017)
VACCINATION DURING ERUPTIVE STAGE OF SMALLPOX.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
When I use a word . . . . New medical words 1422–1972
Authors: Jeffrey K Aronson
Journal: BMJ (2022)

An exploration of the introduction of new medical words into English over time reflects the development of different medical activities. New words that first appeared at 50 year intervals, starting in 1222 and ending in 1972 (n=3886), as logged by the <i>Oxford English Dictionary</i>, include 312 new medical terms. Relatively few medical terms were introduced into the dictionary in those years until 1622. Terms from anatomy and pathology dominated in the 17th and 18th centuries. Terms from biochemistry and pharmacology started to appear in the late 19th century, and terms from genetics and microbiology in the early 20th century. By the mid-20th century new medical terms became more common as a percentage of all new entries, and most specialties contributed, with pharmacology and, to a lesser extent, biochemistry dominating.
T cell receptor beta germline variability is revealed by inference from repertoire data
Authors: Aviv Omer, Ayelet Peres, Oscar L Rodriguez, Corey T Watson, William Lees, Pazit Polak, Andrew M Collins, Gur Yaari
Journal: Genome Medicine (2022)

Abstract Background T and B cell receptor (TCR, BCR) repertoires constitute the foundation of adaptive immunity. Adaptive immune receptor repertoire sequencing (AIRR-seq) is a common approach to study immune system dynamics. Understanding the genetic factors influencing the composition and dynamics of these repertoires is of major scientific and clinical importance. The chromosomal loci encoding for the variable regions of TCRs and BCRs are challenging to decipher due to repetitive elements and undocumented structural variants. Methods To confront this challenge, AIRR-seq-based methods have recently been developed for B cells, enabling genotype and haplotype inference and discovery of undocumented alleles. However, this approach relies on complete coverage of the receptors’ variable regions, whereas most T cell studies sequence a small fraction of that region. Here, we adapted a B cell pipeline for undocumented alleles, genotype, and haplotype inference for full and partial AIRR-seq TCR data sets. The pipeline also deals with gene assignment ambiguities, which is especially important in the analysis of data sets of partial sequences. Results From the full and partial AIRR-seq TCR data sets, we identified 39 undocumented polymorphisms in T cell receptor Beta V (TRBV) and 31 undocumented 5 ′ UTR sequences. A subset of these inferences was also observed using independent genomic approaches. We found that a single nucleotide polymorphism differentiating between the two documented T cell receptor Beta D2 (TRBD2) alleles is strongly associated with dramatic changes in the expressed repertoire. Conclusions We reveal a rich picture of germline variability and demonstrate how a single nucleotide polymorphism dramatically affects the composition of the whole repertoire. Our findings provide a basis for annotation of TCR repertoires for future basic and clinical studies.