tbuckley/cabot-search huggingface dataset:
Abstract 855: Is shift-work associated with increased risk of gastric cancer? A meta-analysis
Authors: Chenyu Sun, Ce Cheng, Chandur Bhan, Mubashir Ayaz Ahmed, Nimararta Bheesham, Jannell F. Lising
Journal: Cancer Research (2021)

Abstract Introduction: Gastric cancer remains one of the most common cancers worldwide. Shift-work involving circadian disruption was designated as a probable cause of cancer by The International Agency for Research on Cancer. Several studies have investigated the impact of shift work on gastric cancer, however, most of them are with small sample size. Thus, this meta-analysis was conducted. Method: A comprehensive literature search on PubMed was conducted to identify all relevant studies published prior to September 2020 according to the established inclusion criteria. The quality assessment was performed by the Newcastle-Ottawa Scale (NOS). The pooled relative risk (RR) and 95% confidence intervals (CI) were calculated to estimate the association between the shift-work and gastric cancer risk. A random-effect or fixed-effect model was used to calculate the pooled RR, based on heterogeneity significance. Subgroup analysis was performed based on rotating-shift versus permanent-shift. Sensitivity analysis and publication bias detection were also performed. All statistical analyses were performed using RevMan software (version 5.3; Cochrane library) and STATA 12.0 statistical software (Stata Corp., College Station, TX), and all P values were two-tailed, the test level was 0.05. Result: 51 articles were obtained from the database search, and 7 articles obtained from other sources. 4 articles involving 36,574 participants were included. All studies were considered moderate to high quality. A non-statistically significant association between shift-work and increased gastric cancer risk was found (RR 1.15, 95%CI: 0.95, 1.37, P=0.14, I2=0%). In the subgroup analysis, neither rotating-shift (RR 1.24, 95%CI: 0.92, 1.67, P=0.16, I2=0%) nor permanent-shift (RR 1.13, 95%CI: 1.10, 0.90, P=0.12, I2=0%) were found to be associated with an increased risk of gastric cancer. Sensitivity analysis by changing fixed-effect models to random-effect models and by omitting each study at a time confirmed the stability of the result. Funnel plot, Egger's test (t=0.70, P=0.554), and Begg's test (z=0.68, P=0.497) found no publication bias of analysis. Conclusion: The current meta-analysis demonstrates that shift-work is not associated with increased gastric cancer risk. However, only four studies were included. More original studies are needed to further explore shift-work impacts on gastric cancer risk. Citation Format: Chenyu Sun, Ce Cheng, Chandur Bhan, Mubashir Ayaz Ahmed, Nimararta Bheesham, Jannell F. Lising. Is shift-work associated with increased risk of gastric cancer? A meta-analysis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 855.
Abstract 3066: DNA ligase IV inhibitor and X-ray exert a synthetic lethal in loss-of-function p53 cells
Authors: Tingting Lin, Zhilian Zhou, Lifeng Zhu, Yandan Fan, Xiaofen Ding, Yingming Sun
Journal: Cancer Research (2021)

Abstract The majority of lung cancer patients receive radiotherapy during the treatment process. Dysfunction of DNA ligase IV impaired non-homologous end joining (NHEJ) and sensitized cells to X-ray. p53 regulated DNA damage repair and was mutated in various lung cancer cells. This study aimed to investigate the synergic effects of DNA ligase IV inhibitor SCR-7 and radiation on both wild-type and p53-deficient lung cancer cells. In the p53 wild-type cell, X-ray and SCR-7 triggered G2/M checkpoint, induced BRCA1, RAD18 activation, and promoted PCNA ubiquitination, facilitating homologous recombination (HR) and translesion synthesis (TLS) rather than NHEJ. In p53-deficient cells, SCR-7 and X-ray exerted a synthetic lethal via inducing more DNA damage, muting TLS, and impairing G2/M checkpoint as dysfunction of Cdc2 and Cyclin B1. Moreover, many cells were collapsed in mitosis catastrophe as a large number of disintegrating chromosomes, and apoptosis was significantly increased. Furthermore, the synergic effects of SCR-7 and X-ray were diminished by exogenous p53 overexpression. Therefore, we hypothesized p53 should be a major regulator of HR and TLS activation when HNEJ deficiency. Our studies indicated that patients with a loss function of p53 might benefit from SCR-7 and radiotherapy with fewer side effects. Citation Format: Tingting Lin, Zhilian Zhou, Lifeng Zhu, Yandan Fan, Xiaofen Ding, Yingming Sun. DNA ligase IV inhibitor and X-ray exert a synthetic lethal in loss-of-function p53 cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 3066.
A Decade of Drug Development through Phase-1 Trials; Systematic Review of Literature for Novel Drugs and Targets in Multiple Myeloma
Authors: Imad Ud Deen, Muhammad Umar Khalid, Atlantis Dawn Russ, Anh Hua, Ahmad Iftikhar, Adeela Mushtaq, Ahmad Safdar, Ali McBride, Faiz Anwer
Journal: Blood (2017)
Abstract #3247: In vitro pharmacological comparison of a carcinoembryonic antigen (CEA)/CD3 bispecific cynomolgus-reactive biosimilar BiTE antibody (CyS111) biosimilar with the clinical candidate MEDI-565 (MT111)
Authors: Michael Oberst, Kathy Mulgrew, Stacy Fuhrmann, Roman Kischel, Petra Lutterbuese, Patrick Baeuerle, Peter Kufer, Peter Kiener, Bahija Jallal, Steven Coats, Scott Hammond
Journal: Cancer Research (2009)

MEDI-565 (MT111) is a bispecific single chain antibody of the BiTE (Bi-specific T-cell engager) class that transiently links carcinoembryonic antigen (CEA; CEACAM5; CD66e) on tumor cells and human CD3 on T cells. This results in the activation of T cells and the subsequent redirected lysis of target cells expressing CEA. MEDI-565 is being developed as a clinical candidate for the treatment of CEA-positive tumors. With the exception of the chimpanzee, MEDI-565 does not cross-react with CD3 orthologs. Therefore, as a potential tool for evaluating mechanistic safety in non-human primates, we constructed a biosimilar antibody, CyS111, which combines the CEA-specific component of MEDI-565 with one that binds cynomolgous CD3. This study characterizes the biological activity of CyS111 as it compares to MEDI-565 to determine its potential utility in assessing safety in a relevant species. CyS111 and MEDI-565 both demonstrated specific lysis of CEA-expressing target cells with similar half-maximal lysis (EC50) values and kinetics of lysis, despite moderate binding affinity differences for species-appropriate CD3 and CEA. However, CyS111 non-specifically activated T cells in the presence of CEA-negative target cells or in the absence of target cells entirely, a feature not shared by MEDI-565. In addition, CyS111 induced proliferation of both CD4+ and CD8+ T cells, whereas MEDI-565 induced CD8+ T cell proliferation with a slower kinetics, and only poorly induced proliferation of CD4+ T cells. Interestingly, aggregated forms of MEDI-565 displayed significantly enhanced potency of BiTE-mediated T cell activation and target cell lysis, whereas CyS111 aggregated forms did not. Taken together, these findings may have implications for the use of biosimilar surrogate molecules for evaluating mechanistic safety.  Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 3247.
The new tumor biomarker miRNA-371a-3p in testicular germ cell tumours: First insights into the molecular function in vitro
Authors: R. Weiten, T. Engler, H. Schorle, J. Ellinger, A. Alajati, M. Ritter, D. Nettersheim, I. Syring-Schmandke
Journal: European Urology (2021)
Serum serotonin level as an independent factor for overactive bladder: Results from the community based cross-sectional study in Japan
Authors: T. Okamoto, A. Imai, S. Hatakeyama, H. Yamamoto, K. Mori, T. Yoneyama, T. Yoneyama, Y. Hashimoto, S. Nakaji, C. Ohyama
Journal: European Urology (2021)
Abstract LB189: Three-dimensional genome organization maps in normal haematopoietic stem cells and acute myeloid leukemia
Authors: Benny Wang, Lingshi Kong, Deepak Babu, Ruchi Choudhary, Winnie Fam, Jia Qi Tng, Yufen Goh, Xin Liu, Fang Fang Song, Priscella Chia, Ming Chun Chan, Omer An, Cheng Yong Tham, Touati Benoukraf, Henry Yang, Wilson Wang, Wee Joo Chng, Daniel Tenen, Melissa J. Fullwood
Journal: Cancer Research (2021)

Abstract Many oncogenes, such as MEIS1 and HOXA9, are overexpressed in some but not all cancers. We identified two key epigenetic mechanisms underlying this heterogeneity in oncogene expression in Acute Myeloid Leukemia. Acute Myeloid Leukemia (AML) is a highly lethal blood cancer arising due to aberrant differentiation of haematopoietic stem cells. MEIS1 and HOXA9 regulate stemness-related transcriptional programs in normal haematopoietic stem cells and AML. Here we obtained 3D genome organization maps in the CD34+ haematopoietic stem cells from healthy individuals and individuals with AML. The MEIS1 oncogenic transcription factor is regulated by a Frequently Interacting Region (FIRE). This FIRE is present in normal bone marrow samples, and an AML sample with high MEIS1 levels. However, it is absent in two AML samples that show low MEIS1 levels. CRISPR excision of the FIRE led to loss of MEIS1 and reduced cell growth. Moreover, MEIS1 can bind to the promoter of HOXA9. HOXA9 can also auto-regulate by binding to its own promoter as well as an Acute Myeloid Leukemia-specific super-enhancer that interacts with the HOXA9 promoter via chromatin interactions. The mechanisms elucidated here could be potentially exploited to utilize epigenetic inhibitors to specifically target oncogene expression in cancer. Citation Format: Benny Wang, Lingshi Kong, Deepak Babu, Ruchi Choudhary, Winnie Fam, Jia Qi Tng, Yufen Goh, Xin Liu, Fang Fang Song, Priscella Chia, Ming Chun Chan, Omer An, Cheng Yong Tham, Touati Benoukraf, Henry Yang, Wilson Wang, Wee Joo Chng, Daniel Tenen, Melissa J. Fullwood. Three-dimensional genome organization maps in normal haematopoietic stem cells and acute myeloid leukemia [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr LB189.
Effect of Paroxetine-Mediated G-Protein Receptor Kinase 2 Inhibition vs Placebo in Patients With Anterior Myocardial Infarction
Authors: Thomas Pilgrim, René Vollenbroich, Sarah Deckarm, Christoph Gräni, Stephan Dobner, Anselm W. Stark, Sophie A. Erne, Flora Babongo Bosombo, Kady Fischer, Stefan Stortecky, Nicole Reusser, Monika Fürholz, George C. M. Siontis, Dik Heg, Lukas Hunziker, Stephan Windecker, Jonas Lanz
Journal: JAMA Cardiology (2021)

Left ventricular remodeling following acute myocardial infarction results in progressive myocardial dysfunction and adversely affects prognosis.To investigate the efficacy of paroxetine-mediated G-protein-coupled receptor kinase 2 inhibition to mitigate adverse left ventricular remodeling in patients presenting with acute myocardial infarction.This double-blind, placebo-controlled randomized clinical trial was conducted at Bern University Hospital, Bern, Switzerland. Patients with acute anterior ST-segment elevation myocardial infarction with left ventricular ejection fraction (LVEF) of 45% or less were randomly allocated to 2 study arms between October 26, 2017, and September 21, 2020.Patients in the experimental arm received 20 mg of paroxetine daily; patients in the control group received a placebo daily. Both treatments were provided for 12 weeks.The primary end point was the difference in patient-level improvement of LVEF between baseline and 12 weeks as assessed by cardiac magnetic resonance tomography. Secondary end points were changes in left ventricular dimensions and late gadolinium enhancement between baseline and follow-up.Fifty patients (mean [SD] age, 62 [13] years; 41 men [82%]) with acute anterior myocardial infarction were randomly allocated to paroxetine or placebo, of whom 38 patients underwent cardiac magnetic resonance imaging both at baseline and 12 weeks. There was no difference in recovery of LVEF between the experimental group (mean [SD] change, 4.0% [7.0%]) and the control group (mean [SD] change, 6.3% [6.3%]; mean difference, -2.4% [95% CI, -6.8% to 2.1%]; P = .29) or changes in left ventricular end-diastolic volume (mean difference, 13.4 [95% CI, -12.3 to 39.0] mL; P = .30) and end-systolic volume (mean difference, 11.4 [95% CI, -3.6 to 26.4] mL; P = .13). Late gadolinium enhancement as a percentage of the total left ventricular mass decreased to a larger extent in the experimental group (mean [SD], -13.6% [12.9%]) compared with the control group (mean [SD], -4.5% [9.5%]; mean difference, -9.1% [95% CI, -16.6% to -1.6%]; P = .02).In this trial, treatment with paroxetine did not improve LVEF after myocardial infarction compared with placebo.ClinicalTrials.gov Identifier: NCT03274752.
Conjugate Electrospun 3D Gelatin Nanofiber Sponge for Rapid Hemostasis
Authors: Xianrui Xie, Dan Li, Yujie Chen, Yihong Shen, Fan Yu, Wei Wang, Zhengchao Yuan, Yosry Morsi, Jinglei Wu, Xiumei Mo
Journal: Advanced Healthcare Materials (2021)

Abstract Developing an excellent hemostatic material with good biocompatibility and high blood absorption capacity for rapid hemostasis of deep non‐compressible hemorrhage remains a significant challenge. Herein, a novel conjugate electrospinning strategy to prepare an ultralight 3D gelatin sponge consisting of continuous interconnected nanofibers. This unique fluffy nanofiber structure endows the sponge with low density, high surface area, compressibility, and ultrastrong liquid absorption capacity. In vitro assessments show the gelatin nanofiber sponge has good cytocompatibility, high cell permeability, and low hemolysis ratio. The rat subcutaneous implantation studies demonstrate good biocompatibility and biodegradability of gelatin nanofiber sponge. Gelatin nanofiber sponge aggregates and activates platelets in large quantities to accelerate the formation of platelet embolism, and simultaneously escalates other extrinsic and intrinsic coagulation pathways, which collectively contribute to its superior hemostatic capacity. In vivo studies on an ear artery injury model and a liver trauma model of rabbits demonstrate that the gelatin nanofiber sponge rapidly induce stable blood clots with least blood loss compared to gelatin nanofiber membrane, medical gauze, and commercial gelatin hemostatic sponge. Hence, the gelatin nanofiber sponge holds great potential as an absorbable hemostatic agent for rapid hemostasis.
Abstract 1770: Ectopic expression of ULBP2 promotes tumor progression in syngeneic mice
Authors: Kosuke Yamaguchi, Naomi Miyake, Yasuhiko Teruya, Kohei Yamane, Naoki Kinoshita, Tomohiro Sakamoto, Masahiro Kodani, Hiroki Chikumi, Akira Yamasaki
Journal: Cancer Research (2021)

Abstract ULBP2 is one of the ligands for NKG2D (NKG2DLs). ULBP2 expression is induced in transformed cells and is recognized by immune effector cells via the activating NKG2D immunoreceptor. Previously, we reported high concentrations of serum-soluble ULBP2 (sULBP2) were correlated with poor prognosis in NSCLC patients. As a possible mechanism, we demonstrated that sULBP2 directly suppressed the cytolytic activity of peripheral blood mononuclear cells (PBMCs). However, little is known about the in vivo function of human NKG2DLs on tumor cells. The present study investigates the function of human NKG2DLs in the syngeneic C57BL/6 mice. We generated ULBP2 stably expressing B16 melanoma cell lines (ULBP2-B16). As previously reported, 4-hour 51Cr releasing assay showed NK cell cytotoxicity against the tumor cells was enhanced by ectopic expression of ULBP2 on the tumor cells. IFN-gamma production in NK cells was decreased by non-contact co-culture with ULBP2-B16. To investigate the in vivo function of ULBP2, C57BL/6 mice were inoculated s.c. with mock-B16 cells or ULBP2-B16 cells. ULBP2-B16 tumors grew rapidly compared to mock-B16 tumors. NKG2D blockade by anti-NKG2D antibody injected i.p. suppressed tumor growth of ULBP2-B16 tumors. Spleen cells and tumor-infiltrating lymphocytes (TILs) were analyzed by flow cytometry. NKG2D was expressed on splenic NK cells, while it was rarely expressed on splenic CD8+ T cells. NKG2D was downregulated on NK cells in TILs (NK-TILs) from ULBP2-B16. NKG2D was highly expressed on CD8+ T cells in TILs (CD8+-TILs) from mock-B16 tumors, while its expression was suppressed on these from ULBP2-B16 tumors. Degranulation analysis revealed that ULBP2-B16 reduced activity of NK-TILs and CD8+-TILs compared to mock-B16. In conclusion, ectopic expression of ULBP2 on tumor cells promotes tumor progression via suppression of the activity of NK cells and CD8+ T cells. These findings suggest that neutralization of NKG2DLs may be a promising approach for the treatment of NKG2DLs-expressing tumors. Citation Format: Kosuke Yamaguchi, Naomi Miyake, Yasuhiko Teruya, Kohei Yamane, Naoki Kinoshita, Tomohiro Sakamoto, Masahiro Kodani, Hiroki Chikumi, Akira Yamasaki. Ectopic expression of ULBP2 promotes tumor progression in syngeneic mice [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 1770.
No veterinarians (yet) on the Italian covid-19 scientific committee
Authors: Giovanni Di Guardo
Journal: BMJ (2021)

The challenges and uncertainties of covid-19 continue.1 As a retired veterinary pathologist, with almost 20 years of academic and teaching experience in general pathology and veterinary pathophysiology, I feel great discomfort that not a single veterinarian sits on the Italian Scientific and Technical Committee for the Covid-19 Pandemic.

This committee, popularly known by the acronym CTS (Comitato Tecnico Scientifico), was officially established in Italy in …
TGF-β blockade-improved chemo-immunotherapy with pH/ROS cascade-responsive micelle via tumor microenvironment remodeling
Authors: Liangliang Dai, Xiang Li, Xinmin Zheng, Zhenxiang Fu, Mengjiao Yao, Siyu Meng, Jiangong Zhang, Binbin Han, Quanli Gao, Jing Chang, Kaiyong Cai, Hui Yang
Journal: Biomaterials (2021)
Metastasis-directed therapy for oligorecurrent prostate cancer: A pooled analysis of prospective trials
Authors: P. Ost, B. Alejandro, S. Siva, D. Reynders, R.M. Phillips, R. Glicksman, F. Foroudi, V. Fonteyne, M.P. Deek, P. Chung, D. Murphy, P.T. Tran
Journal: European Urology (2021)
Tracheostomy decannulation in severe acquired brain injury patients: The role of flexible bronchoscopy
Authors: B. Lanini, B. Binazzi, I. Romagnoli, E. Chellini, L. Pianigiani, A. Tofani, R. Molino Lova, L. Corbetta, F. Gigliotti
Journal: Pulmonology (2021)

Subjects with severe acquired brain injury (sABI) require long-term mechanical ventilation and, as a consequence, the tracheostomy tube stays in place for a long time. In this observational study, we investigated to what extent the identification of late tracheostomy complications by flexible bronchoscopy (FBS) might guide clinicians in the treatment of tracheal lesions throughout the weaning process and lead to successful decannulation. One hundred and ninety-four subjects with sABI admitted to our rehabilitation unit were enrolled in the study. All subjects received FBS and tracheal lesions were treated either by choosing a more suitable tracheostomy tube, or by laser therapy, or by steroid therapy, or by a combination of the above treatments. Overall, 122 subjects (63%) were decannulated successfully. Our subjects received 495 FBSs (2.55 per subject) and as many as 270 late tracheostomy complications were identified. At least one complication was found in 160 subjects (82%). In only 11 subjects, late tracheostomy complications did not respond to the treatment and were the cause of decannulation failure. In conclusion, in sABI patients FBS is able to guide successful tracheostomy weaning in the presence of late tracheostomy complications that could get in the way decannulation.
A neural code for egocentric spatial maps in the human medial temporal lobe
Authors: Lukas Kunz, Armin Brandt, Peter C. Reinacher, Bernhard P. Staresina, Eric T. Reifenstein, Christoph T. Weidemann, Nora A. Herweg, Ansh Patel, Melina Tsitsiklis, Richard Kempter, Michael J. Kahana, Andreas Schulze-Bonhage, Joshua Jacobs
Journal: Neuron (2021)
COVID-19 vaccine acceptance and hesitancy in low- and middle-income countries
Authors: Julio S. Solís Arce, Shana S. Warren, Niccolò F. Meriggi, Alexandra Scacco, Nina McMurry, Maarten Voors, Georgiy Syunyaev, Amyn Abdul Malik, Samya Aboutajdine, Opeyemi Adeojo, Deborah Anigo, Alex Armand, Saher Asad, Martin Atyera, Britta Augsburg, Manisha Awasthi, Gloria Eden Ayesiga, Antonella Bancalari, Martina Björkman Nyqvist, Ekaterina Borisova, Constantin Manuel Bosancianu, Magarita Rosa Cabra García, Ali Cheema, Elliott Collins, Filippo Cuccaro, Ahsan Zia Farooqi, Tatheer Fatima, Mattia Fracchia, Mery Len Galindo Soria, Andrea Guariso, Ali Hasanain, Sofía Jaramillo, Sellu Kallon, Anthony Kamwesigye, Arjun Kharel, Sarah Kreps, Madison Levine, Rebecca Littman, Mohammad Malik, Gisele Manirabaruta, Jean Léodomir Habarimana Mfura, Fatoma Momoh, Alberto Mucauque, Imamo Mussa, Jean Aime Nsabimana, Isaac Obara, María Juliana Otálora, Béchir Wendemi Ouédraogo, Touba Bakary Pare, Melina R. Platas, Laura Polanco, Javaeria Ashraf Qureshi, Mariam Raheem, Vasudha Ramakrishna, Ismail Rendrá, Taimur Shah, Sarene Eyla Shaked, Jacob N. Shapiro, Jakob Svensson, Ahsan Tariq, Achille Mignondo Tchibozo, Hamid Ali Tiwana, Bhartendu Trivedi, Corey Vernot, Pedro C. Vicente, Laurin B. Weissinger, Basit Zafar, Baobao Zhang, Dean Karlan, Michael Callen, Matthieu Teachout, Macartan Humphreys, Ahmed Mushfiq Mobarak, Saad B. Omer
Journal: Nature Medicine (2021)

Abstract Widespread acceptance of COVID-19 vaccines is crucial for achieving sufficient immunization coverage to end the global pandemic, yet few studies have investigated COVID-19 vaccination attitudes in lower-income countries, where large-scale vaccination is just beginning. We analyze COVID-19 vaccine acceptance across 15 survey samples covering 10 low- and middle-income countries (LMICs) in Asia, Africa and South America, Russia (an upper-middle-income country) and the United States, including a total of 44,260 individuals. We find considerably higher willingness to take a COVID-19 vaccine in our LMIC samples (mean 80.3%; median 78%; range 30.1 percentage points) compared with the United States (mean 64.6%) and Russia (mean 30.4%). Vaccine acceptance in LMICs is primarily explained by an interest in personal protection against COVID-19, while concern about side effects is the most common reason for hesitancy. Health workers are the most trusted sources of guidance about COVID-19 vaccines. Evidence from this sample of LMICs suggests that prioritizing vaccine distribution to the Global South should yield high returns in advancing global immunization coverage. Vaccination campaigns should focus on translating the high levels of stated acceptance into actual uptake. Messages highlighting vaccine efficacy and safety, delivered by healthcare workers, could be effective for addressing any remaining hesitancy in the analyzed LMICs.
Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondrial disease
Authors: Shanshan Liu, Song Fu, Guodong Wang, Yu Cao, Lanlan Li, Xuemei Li, Jun Yang, Ning Li, Yabing Shan, Yang Cao, Yan Ma, Mengqiu Dong, Qinghua Liu, Hui Jiang
Journal: Cell Metabolism (2021)