tbuckley/cabot-search huggingface dataset:
Characterization of promoter elements of the rabbit cardiac sarcoplasmic reticulum Ca(2+)-ATPase gene required for expression in cardiac muscle cells.
Authors: S AFisher, P MButtrick, DSukovich, MPeriasamy
Journal: Circulation Research (1993)

The sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2) plays a critical role in the contractile performance of cardiac and slow-twitch skeletal muscle by restoring cytosolic calcium to low resting levels during the contractile cycle. We have previously shown that SERCA2 expression in the heart is altered by a number of pathophysiological stimuli. In an effort to define molecular mechanisms regulating expression of the SERCA2 gene in cardiac muscle cells, deletions of a 1460-bp promoter fragment were generated and inserted into a luciferase reporter plasmid. Promoter constructs were transiently transfected into embryonic cardiocytes and skeletal muscle cell lines Sol 8 and C2C12 in vitro and injected into adult myocardium in vivo. Results demonstrate that sequences from the transcription start site to -284 are both necessary and sufficient for high-level transcription of the reporter gene in differentiating muscle cells and in fetal cardiocytes in culture. We further demonstrate that this promoter fragment is h...
Assessment of transesophageal pulsed Doppler echocardiography in the detection of mitral regurgitation.
Authors: MSchlüter, B ALangenstein, PHanrath, PKremer, WBleifeld
Journal: Circulation (1982)

The value of transesophageal pulsed Doppler echocardiography (PDE) was studied in six patients with competent mitral valve and in 12 patients with angiographically proved mild to moderately severe mitral regurgitation. The results were compared with those from the standard transthoracic method of investigation. The advantages of the esophageal over the transthoracic approach in the detection of mitral regurgitation are (1) absence of anatomic obstacles between the ultrasound transducer and the heart; (2) nearly parallel alignment of the ultrasound beam with the blood flow direction; (3) the use of high pulse repetition frequencies; and (4) detection of localized regurgitant jets by left atrial scanning. This results in a superior recording quality and greater sensitivity. Based on a specific systolic flow pattern in the time-interval histogram, mitral regurgitation was detected in all patients by the transesophageal technique (100% sensitivity), but in only 58% by the precordial approach. Thus, transesoph...
The British Association of Dermatologists audit of atopic eczema management in secondary care. Phase 2: audit of service process
Authors: K.W. Shum, S. Lawton, H.C. Williams, G. Docherty, J. Jones
Journal: British Journal of Dermatology (2000)

An audit of atopic eczema management, conducted on behalf of the British Association of Dermatologists, examined service structure (phase 1), process (phase 2) and outcome (phase 3). In phase 2, an on-site case-note audit was conducted in 19 hospital dermatology departments randomly selected from the original sample of 187 centres across the U.K. In total, 630 sets of notes were examined for completeness of: (i) information given to general practitioners (GPs) in clinic letters and (ii) facts relevant to the management of atopic eczema recorded in the patients’ notes. In general, the information given to GPs in the clinic letters was good, with the recording of diagnosis, treatment and follow-up approaching the 100% working standard. Factual information such as site and severity of eczema (83% and 74%), and presence or absence of asthma (53%) were better recorded than quality of life issues such as sleep loss secondary to itching (21%) and effect on school, work or social life (6%). On average, only 51% of all audit measures were recorded across all centres, with slight variation between centres (41–61%). The centre with the best recording had a purpose-designed data sheet for doctors to complete when seeing new patients with atopic eczema. Such data sheets may help improve case-note recording. Similar data sheets for patients to complete may be more time-efficient.
Viscoelastic behavior of the thoracic aorta of dogs and rabbits.
Authors: B JGentile, D RGross
Journal: Circulation Research (1985)

Data are presented which demonstrate no correlation between atrial electrical activity and diameter changes in the descending thoracic aorta of dogs or rabbits. The experiments conducted included bypassing a segment of the descending thoracic aorta in dogs, and production of a variety of arrhythmias without the bypass in dogs and rabbits. We found no evidence of electrical stimulation-induced phasic activity as suggested by other authors.
A model for early afterdepolarizations: induction with the Ca2+ channel agonist Bay K 8644.
Authors: C TJanuary, J MRiddle, J JSalata
Journal: Circulation Research (1988)

Early afterdepolarizations (EADs) are one mechanism proposed to cause certain cardiac arrhythmias. We studied the effect of the Ca2+ channel agonist Bay K 8644 (1 x 10(-8) to 5 x 10(-5) M) on normally polarized sheep and canine cardiac Purkinje fiber short segments. EADs occurred with higher Bay K 8644 concentrations and had an average take-off potential of -34 mV. The initiation of EADs was preceded by lengthening of action potential duration and flattening of the plateau. Induction of EADs with Bay K 8644 was enhanced by low stimulation frequencies, lowering of [K]o, addition of tetraethylammonium chloride, or application of depolarizing constant current pulses during the plateau. EADs were abolished by increasing stimulation frequency, raising [K]o, the addition of tetrodotoxin, lidocaine, ethmozin, verapamil, and nitrendipine, or application of repolarizing constant current pulses. Using current pulses to modify the action potential plateau, a steep inverse relationship was found between the EAD peak ...
Protective effect of increased glycolytic substrate against systolic and diastolic dysfunction and increased coronary resistance from prolonged global underperfusion and reperfusion in isolated rabbit hearts perfused with erythrocyte suspensions.
Authors: F REberli, E OWeinberg, W NGrice, G LHorowitz, C SApstein
Journal: Circulation Research (1991)

Current  of myocardial infarction may include early reperfusion. We simulated myocardial perfusion conditions during evolving myocardial infarction in isolated, normothermic, isovolumic rabbit hearts perfused with buffer containing bovine red blood cells (hematocrit of 40%), and we assessed the effects of high levels of glucose and insulin as therapy during prolonged (150-minute) severe underperfusion and reperfusion. Protocol 1 consisted of underperfusion at a constant coronary perfusion pressure of 8 mm Hg. The control group (n = 8) received 5.5 mmol/l glucose and 15 microunits/ml insulin; the group treated with high levels of glucose and insulin (G + I) (n = 8) received 19.5 mmol/l glucose and 250 microunits/ml insulin during both underperfusion and reperfusion. Relative to the control group, the G + I group experienced 1) greater developed pressure during underperfusion and increased recovery during reperfusion, 2) preserved diastolic function during underperfusion and reperfusion, 3) lower c...
Enhancement of platelet aggregation by tranylcypromine in mouse cerebral microvessels.
Authors: W IRosenblum, FEl-Sabban
Journal: Circulation Research (1978)

Tranylcypromine, given intraperitoneally at doses greater than or equal to 10 mg/kg, enhanced platelet aggregation in the arterioles on the cerebral surface in mice. Tranylcypromine inhibits prostacyclin synthesis in vitro. Iproniazid, which inhibits monoamine oxidase but not prostacyclin synthesis, failed to enhance platelet aggregation. The failure of iproniazid to enhance aggregation in this study rules out an effect on monoamine oxidase as the cause of tranylcypromine's action. That iproniazid inhibited aggregation indicates it has an effect opposite to that of tranylcypromine. Imidazole, a drug known to inhibit synthesis of both prostacyclin and thromboxane, failed to affect platelet aggregation. All of our data are compatible with the hypothesis that prostacyclin is an inhibitor of platelet aggregation. This hypothesis has been based largely on in vitro data, to which we now add in vivo support.
Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus.
Authors: M TJohnstone, S JCreager, K MScales, J ACusco, B KLee, M ACreager
Journal: Circulation (1993)

BACKGROUNDEndothelium-dependent vasodilation is abnormal in experimental models of diabetes mellitus. We postulated that abnormalities of endothelial function are also present in patients with insulin-dependent diabetes mellitus and may contribute to the pathogenesis of vascular disease in these individuals.METHODS AND RESULTSVascular reactivity was measured in the forearm resistance vessels of 15 patients with insulin-dependent diabetes mellitus and 16 age-matched normal subjects. No patient had hypertension or dyslipidemia. Each subject was pretreated with aspirin to inhibit endogenous production of prostanoids. Methacholine chloride (0.3 to 10 micrograms/min) was administered via the brachial artery to assess endothelium-dependent vasodilation. Sodium nitroprusside (0.3 to 10 micrograms/min) and verapamil (10 to 300 micrograms/min) were infused intra-arterially to assess endothelium-independent vasodilation; phenylephrine (0.3 to 3 micrograms/min) was administered to examine vasoconstrictor responsiven...
Pharmacodynamics of thrombolysis with recombinant tissue-type plasminogen activator. Correlation with characteristics of and clinical outcomes in patients with acute myocardial infarction. The TAMI Study Group.
Authors: D CStump, R MCaliff, E JTopol, KSigmon, DThornton, RMasek, LAnderson, DCollen
Journal: Circulation (1989)

Coagulation analysis was performed on blood samples from 386 patients with acute myocardial infarction drawn before, during, and after a continuous intravenous infusion of 150 mg recombinant tissue-type plasminogen activator (rt-PA) (Activase). Plasma rt-PA rose to peak levels of 2.1 +/- 3.1 micrograms/ml (mean +/- SD). Fibrinogen levels measured by coagulation rate and by sulfite precipitation decreased from baseline levels of 3.0 +/- 0.9 and 3.2 +/- 1.0 g/l, respectively, to nadir levels of 1.4 +/- 0.75 and 1.8 +/- 0.92 g/l, respectively, and were associated with peak levels in serum of fibrinogen-degradation products (FDP) of 230 +/- 470 micrograms/ml. Forty percent of patients experienced a nadir functional-fibrinogen level of less than 1.0 g/l, whereas 20% fell below 0.5 g/l. Nadir fibrinogen levels did not correlate with patency of the infarct-related coronary artery at 90 minutes or with risk of coronary vessel reocclusion within 7-10 days. However, the risk of coronary artery reocclusion was inver...
In vivo assessment of left atrial contractile performance in normal and pathological conditions using a time-varying elastance model.
Authors: B DHoit, YShao, MGabel, R AWalsh
Journal: Circulation (1994)

BACKGROUNDContractile function of the ex vivo, isolated left atrium (LA) has been described by a time-varying elastance, but this atrial chamber property has not been shown in vivo.METHODS AND RESULTSInstantaneous LA pressure-volume (P-V) relations were studied in 12 anesthetized, autonomically blocked, atrially paced dogs. LA volume was calculated from orthogonal sonomicrometer pairs using a cast-validated formula. Data were collected during increases in LA pressure produced by a phenylephrine bolus (200 to 400 micrograms IV). Isochronal P-V points from 5 beats, representing a wide range of atrial pressures, were fitted by linear regression analysis (range of R2, .92 to .99). There were significant time-dependent increases in the slopes [E(t)] and small but statistically insignificant decreases in the volume axis intercepts [VO(t)] of the instantaneous LA P-V relations during atrial contraction; maximal elastance (Emax) occurred 29 +/- 16 milliseconds before atrial end systole (minimal LA volume). Emax w...
Thrombolysis in Myocardial Infarction (TIMI) Trial, Phase I: A comparison between intravenous tissue plasminogen activator and intravenous streptokinase. Clinical findings through hospital discharge.
Authors: J HChesebro, GKnatterud, RRoberts, JBorer, L SCohen, JDalen, H TDodge, C KFrancis, DHillis, PLudbrook
Journal: Circulation (1987)

Intravenous administration of 80 mg of recombinant tissue plasminogen activator (rt-PA, 40, 20, and 20 mg in successive hours) and streptokinase (SK, 1.5 million units over 1 hr) was compared in a double-blind, randomized trial in 290 patients with evolving acute myocardial infarction. These patients entered the trial within 7 hr of the onset of symptoms and underwent baseline coronary arteriography before thrombolytic therapy was instituted. Ninety minutes after the start of thrombolytic therapy, occluded infarct-related arteries had opened in 62% of 113 patients in the rt-PA and 31% of 119 patients in the SK group (p less than .001). Twice as many occluded infarct-related arteries opened after rt-PA compared with SK at the time of each of seven angiograms obtained during the first 90 min after commencing thrombolytic therapy. Regardless of the time from onset of symptoms to treatment, more arteries were opened after rt-PA than SK. The reduction in circulating fibrinogen and plasminogen and the increase ...
Coarctation of the aorta with ventricular septal defect.
Authors: W HNeches, S CPark, C CLenox, J RZuberbuhler, R DSiewers, R LHardesty
Journal: Circulation (1977)

From 1965 to 1974, 53 children with coarctation of the aorta (COA) and an associated ventricular septal defect (VSD) underwent cardiac catheterization. Thirty-one patients presented with congestive heart failure. Twenty-five of 27 patients (92%) who underwent cardiac catheterization under age 3 months had either systemic hypertension, a systolic gradient across the coarctation greater than 20 mm Hg or both. Pulmonary hypertension was present in all 25 patients. COA repair was performed in 39 patients and there were seven deaths. Of the 32 survivors, 23 have no residual gradient; six are normotensive but have a mild residual gradient; three are hypertensive or have a gradient greater than 20 mm Hg. Repair of the VSD or pulmonary artery banding has been performed in 11 of 44 patients who survived infancy. Spontaneous closure of the VSD has occurred in three cases and 25 patients have a small VSD that does not warrant surgical repair. Surgical repair of COA during infancy may be unavoidable but conservative ...
Calcium and Vitamin D Supplements and Fractures in Community-Dwelling Adults—Reply
Authors: Jia-Guo Zhao, Xian-Tie Zeng, Jia Wang
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intraluminal ultrasound imaging through a balloon dilation catheter in an animal model of coarctation of the aorta.
Authors: ARothman, FRicou, R GWeintraub, RCrowley, RArcangeli, TShiota, JZhang, D JSahn
Journal: Circulation (1992)

BACKGROUNDControversy still exists over the optimal balloon size, extent of vascular disruption, and long-term results of balloon dilation therapy for coarctation of the aorta. Intravascular ultrasound imaging has been used in patients with coronary artery disease to provide further insight into the anatomy of atherosclerotic lesions and the results of angioplasty and atherectomy. Initial observations of the results of balloon dilation of coarctations with intravascular ultrasound imaging have shown prominent dissections of the inner vascular layers that are often not detected by angiography. The purpose of this study was to test a new transballoon catheter ultrasonic imaging system capable of on-line direct visualization of lumen diameter and vessel wall structure for imaging before, during, and after dilation in an acute animal model of aortic coarctation.METHODS AND RESULTSAbdominal aortic coarctations were created surgically in three 14-19-kg mongrel dogs by using Teflon gauze ties. The 6.8F ultrasoun...
Noncontact mapping to guide ablation of right ventricular outflow tract tachycardia
Authors: Paul A Friedman, Samuel J Asirvatham, Suellen Grice, Michael Glikson, Thomas M Munger, Robert F Rea, Win K Shen, Arshad Jahanghir, Douglas L Packer, Stephen C Hammill
Journal: Journal of the American College of Cardiology (2002)
Contingent Fees and Malpractice
Authors: H. T. Montgomery
Journal: JAMA (1972)

<h3>To the Editor.—</h3> I read, with much interest, Mr. McCabe's defense of contingent fees in the practice of law, and noted his comments on the inadequacies of the system. However, in attempting to emphasize his point, Mr. McCabe chooses an example which is inappropriate by implying that the cardiac surgeon who lost the patient on the table should not have sent a bill for medical services. Fees for medical services, as Mr. McCabe must certainly know, are customarily for a set dollar amount and are not tied to loss of services, future earning power, pain and suffering, and other such ethereal considerations. I feel reasonably certain that Mr. McCabe is not unaware of legal fees amounting to as much as $500,000.00 for the plaintiff's attorney for the successful prosecution of a case of personal injury or malpractice. I cannot help wondering how Mr. McCabe would react had his client received
Ventricular action potentials, ventricular extracellular potentials, and the ECG of guinea pig.
Authors: TWatanabe, P MRautaharju, T FMcDonald
Journal: Circulation Research (1985)

Action potentials were recorded from different regions of the guinea pig ventricle to characterize regional differences in waveform configuration, and to acquire insight into the generation of the T-wave of the electrocardiogram. Isolated tissue preparations were driven at 1 Hz, and microelectrodes were used to map accessible surface regions of the epicardium, endocardium, and septum. There were minimal differences in regional resting potentials (mean -87 mV) and amplitudes (mean 122 mV), but Vmax in the epicardium (mean 110 V/sec) was much smaller than elsewhere (mean 247 V/sec). The action potential duration at the -80 mV repolarization level was longest in the papillary muscles (mean 154 msec), shortest in the septum (mean 126 msec), and generally 10-15 msec longer at the base than at the apex. The characteristics of intramural action potentials were inferred from measurements on enzymatically isolated myocytes, the rationale being that most dissociated myocytes originated from intramural cell layers. ...
Suppression of ventricular ectopic depolarizations by flecainide acetate, a new antiarrhythmic agent.
Authors: MHodges, J MHaugland, GGranrud, G JConard, R WAsinger, F LMikell, JKrejci
Journal: Circulation (1982)

Flecainide acetate, a new antiarrhythmic agent, was given orally to 11 hospitalized patients with chronic high-frequency ventricular ectopic depolarizations. Drug effectiveness was evaluated with a dose-ranging single-blind protocol, which included placebo control and washout periods. Twice-daily dosing (average daily dose 436 mg) completely suppressed all ventricular ectopic activity in five of 11 patients; average suppression in the 11 patients was 96.3%. Complex ventricular arrhythmias, which were present in all 11 patients during the placebo control period, were completely suppressed in eight patients and markedly suppressed in the other three patients during flecainide therapy. Ejection fraction and velocity of circumferential fiber shortening measured by M-mode echocardiography did not change significantly during flecainide dosing. Ventricular arrhythmias returned in all patients during the placebo washout period. During subsequent outpatient therapy with flecainide, significant suppression was pres...
Possible involvement of an endogenous opioid in the antihypertensive effect of clonidine in patients with essential hypertension.
Authors: CFarsang, JKapocsi, IJuhasz, GKunos
Journal: Circulation (1982)

The effect of naloxone on the hypotensive and bradycardiac action of clonidine was studied in 27 hospitalized patients with uncomplicated mild-to-moderate essential hypertension. In a double-blind, crossover study, clonidine, 0.3 mg/day orally for 3 days, significantly reduced systolic and diastolic blood pressure and heart rate, whereas placebo was ineffective. Naloxone, 0.4 mg given intravenously on the third day of clonidine treatment, caused a rapid increase in blood pressure and heart rate in 14 patients (reacting group), but was ineffective in the remaining 13 patients (nonreacting group). Naloxone given during the placebo period was ineffective in all patients. Both the clonidine-induced hypotension and the rebound increase in blood pressure after cessation of clonidine were significantly greater in the reacting than in the nonreacting group. These observations suggest that release of an endogenous opioid contributes to the antihypertensive action of clonidine; this mechanism may be also involved i...
Treatment Decisions for Patients with Cancer during the COVID-19 Pandemic
Authors: Chris Labaki, Solange Peters, Toni K. Choueiri
Journal: Cancer Discovery (2021)

Abstract Patients with cancer have been disproportionally affected by the COVID-19 pandemic, with high rates of severe outcomes and death. Similarly, treatment decisions in this vulnerable population have been altered to a major degree during the past year, with significant disruption of care reported. Although complex, therapeutic choices in patients with cancer in times of COVID-19 are critical, as they may save thousands of lives. A mounting body of evidence, in addition to clear recommendations by multiple international societies, can help oncologists decide appropriately the necessity to administer antineoplastic regimens, helping to avoid a surge in cancer-related deaths in the upcoming months.
Handbook of Paediatric Dermatology.
Journal: Annals of Internal Medicine (1986)

Introduction the newborn infantile seborrhoeic eczema nappy rash atopic eczema other types of eczema warts and mollusci contagios impetigo candidiasis other viral and bacterial skin infections tropical dermatoses superficial fungal infections infestations exanthems urticaria and the erythemas acne psoriasis and other papulosquamous disorders blisters and the bullous dermatoses naevi skin modules disorders of pigmentation photosensitivity hair nails inherited diseases - the genodermatoses the skin and systemic disease diseases of the oral mucosa and tongue.