tbuckley/cabot-search huggingface dataset:
Ciprofloxacin in the Treatment of Nosocomial Meningitis in Neonates and Infants
Authors: J Filka, J Uher, H Kurak, T ??ag??t, J Tuharsky, I Nov??k, T Ur banov??, K Kralinsky, S Dluholucky, T Krcm??ryov??, V Krcm??ry
Journal: Drugs (1999)
Training for excellence in the inner city: an interview with Richard Savage and Clare Vaughan
Authors: D. Carnall
Journal: BMJ (1996)

Recruitment to general practice is at its lowest level for 30 years, and many vocational training schemes report difficulty in attracting new trainees. Spurred on by the aging population of south London, and with the advantage of pounds 1.3m of development money resulting from the Tomlinson report, the south London organisation of vocational training schemes (SLOVTS) has perhaps been able to cope better than most. Its chair, Richard Savage, a general practitioner and course organiser, and Clare Vaughan, an assistant adviser, have devised and implemented many innovative training posts for general practice over the past two years, and their approach seems to be bearing fruit: most of the doctors who have finished the training scheme are now entering practice in south London. They talked to Douglas Carnall about the causes of the crisis and the measures they have implemented to counter it. Clare Vaughan died in the week following the interview (see obituary, p 555).
YKL-40 expression in naevocellular naevi, carcinomas and melanomas of the skin
Authors: H. Schmidt, A. Roslind, J. S. Johansen, D. L. Nielsen, P. A. Price, E. Balslev
Journal: Journal of Clinical Oncology (2006)

18019 Background: Elevated serum levels of the protein YKL-40 are associated with a poor prognosis in several solid tumors including melanoma (H. Schmidt, JCO 2006, Cancer 2006 in press). YKL-40 is secreted by cancer cells, macrophages and neutrophils. The function of YKL-40 is only poorly understood. It may be a growth or differentiation factor, play a role in angiogenesis or protect against apoptosis. The aim was to describe the tissue expression of YKL-40 in naevocellular naevi, carcinomas and melanomas of the skin by immunohistochemistry. Methods: Paraffin-embedded tissue sections from 40 patients with different naevocellular naevi, carcinomas and melanomas of the skin were developed with EnVision+ System-HRP K4007 (DakoCytomation) using a monoclonal antibody against YKL-40. The intensity of YKL-40 staining was scored using a semi-quantitative method. Results: YKL-40 protein expression appeared as a cytoplasmic, granular staining with no staining of membranes, nuclei or extracellular matrix. In normal skin the basal epithelial layer stained weakly positive. Melanocytes and melanophages stained negative. Macrophages and leucocytes stained positive. Hair follicles, sebaceous glands and sweat glands stained positive. Three basal cell carcinomas all stained positive. In 10 squamous cell carcinomas, the epidermal components stained positive and the invasive tumor islands were negative. In 3 keratoacanthomas, the epithelial components as well as the infiltrative tumor islands stained positive. In naevi (2 junctional, 5 compound and 1 intradermal) the epithelial components stained positive, the intradermal components stained negative. In melanomas the tumor cells stained positive in 9 of 10 specimens. Both the epidermal and the invasive components of melanomas stained positive. Three melanoma metastases all stained positive. Conclusions: YKL-40 is expressed in normal skin and in benign and malignant lesions of the skin. Generally, YKL-40 expression is increased in cells of high activity, although the invasive tumor islands of squamous cell carcinomas stain negative. In melanomas, the tumor cells may be a source of the elevated YKL-40 serum levels observed in these patients. No significant financial relationships to disclose.
Self-reported concern about food security-eight states, 1996-1998.
Authors: C. Hunt, B. Bates, A. Weinstein, J. Jackson-Thompson, P. Feigley, L. Mann, M. Wu, K. Carswell, K. R. Evenson, A. L. Perry, B. A. Laraia
Journal: MMWR Morbidity and Mortality Weekly Report (2000)
Abstract 5963: Prevention of Tilt-Table Induced Vasovagal Response by Angiotensin-Converting Enzyme Inhibition
Authors: Spyridon Deftereos, Georgios Giannopoulos, Nikolaos Kouvousis, Konstantinos Raisakis, Charalampos Kossyvakis, Olga Ntzouvara, Metaxia Driva, Vasiliki Panagopoulou, Nikolaos Michelakakis, Evaggelos Matsakas
Journal: Circulation (2008)

The use of various pharmacologic agents has been proposed for the preventive treatment of vasovagal syncopal episodes, with conflicting efficacy results from various studies. Angiotensin-converting enzyme inhibitors (ACEIs), although reported in small studies to have a beneficial effect in patients with vasovagal syncope, have not been generally accepted as part of conventional treatment in such patients. Our population consisted of 125 consecutive patients (60 male, mean age 40±15 years), with a positive head-up tilt-table testing (HUTTT) (cardioinhibitory or vasodepressive or mixed response), who were randomized to receive either the ACEI fosinopril (N=63), at a dose of 10 mg qd, or placebo (N=62), for 30 days. They were then submitted to a new HUTTT (80 degrees, before and after infusion of isoproterenol, at a max. rate of 5 mcg/min). Before randomization, the patients were stratified according to the use of other vasoactive agents. Physicians performing the HUTTT were blinded as to each patient’s randomization group. Twenty-eight (44%) of fosinopril-treated patients were positive in the second HUTTT versus 52 (84%) in the placebo group (p=0.015). In a multivariate analysis, entering, apart from the treatment group, patient age, gender, smoking habit, hypertension, the use of beta-blocking agents and various demographic factors, with a negative result in the second HUTTT as the dependent variable, female gender, younger age and the use of fosinopril were independently associated with a negative repeat HUTTT. The present study reports a potential preventive effect of ACEIs in vasovagal syncope and indicates that younger, female patients, taking fosinopril were more likely to have a negative repeat HUTTT. The observed effect may be related to the ability of ACEIs to reduce cardiac wall tension, thus decreasing the activation of C-mechanoreceptors, as well as to their potential to inhibit angiotensin-related catecholamine release.
The World Health Organisation: WHO at country level -- a little impact, no strategy
Authors: F. Godlee
Journal: BMJ (1994)

The acid test of WHO's effect on the world's health is its impact at country level. Unless it has an impact there, all of its declarations, its debates at the World Health Assembly, its conferences, its pamphlets, its political manouvering in Geneva and the regions, all of these come to nothing. Working as it does through national governments, WHO insists that it has no role in directly managing or delivering health care. Judging WHO's impact in individual countries is therefore difficult--its approaches are largely indirect, and initiatives may take years to bear fruit. But from the meagre resources that WHO makes available at country level it is clear why its country operations are criticised as the weakest link in an already weak chain of influence from its headquarters in Geneva to the people in its member states. Poorly funded, undertrained, and with no clear strategy to follow, its staff at country level stand little chance of making an impact.
Stereotactic Body Radiotherapy Using a Radiobiology-Based Regimen for Stage I Non–Small-Cell Lung Cancer: Five-Year Mature Results
Authors: Yuta Shibamoto, Chisa Hashizume, Fumiya Baba, Shiho Ayakawa, Akifumi Miyakawa, Taro Murai, Taiki Takaoka, Yukiko Hattori, Ryuji Asai
Journal: Journal of Thoracic Oncology (2015)
Delineation of a novel pre-B cell component in plasma cell myeloma: immunochemical, immunophenotypic, genotypic, cytologic, cell culture, and kinetic features
Authors: TM Grogan, BG Durie, C Lomen, C Spier, DP Wirt, R Nagle, GS Wilson, L Richter, E Vela, V Maxey
Journal: Blood (1987)
Role of Zscan4 in secondary murine iPSC derivation mediated by protein extracts of ESC or iPSC
Authors: Yoo-Wook Kwon, Jae-Seung Paek, Hyun-Jai Cho, Choon-Soo Lee, Ho-Jae Lee, In-Hyun Park, Tae-Young Roh, Chang-Mo Kang, Han-Mo Yang, Young-Bae Park, Hyo-Soo Kim
Journal: Biomaterials (2015)
Abstract 15947: Merging Three-Dimensional Cardiac MRI with Electroanatomical Mapping to Guide Transendocardial Injections of Mesenchymal Stem Cells
Authors: Adam R Williams, Juan P Zambrano, Jose Rodriguez, Daniel Guerra, Gisela Bonny, Ian McNiece, Joshua M Hare, Alan W Heldman
Journal: Circulation (2010)

Background:  Merged CT/MRI with electroanatomical maps (EAM) have been used to guide catheters in electrophysiological interventions. We hypothesized that a novel approach, using reconstructed three-dimensional cardiac MRI of the left ventricle merged with an EAM could guide transendocardial delivery of mesenchymal stem cells (MSCs).   Methods and Results:  Gottingen swine (n=7) underwent LAD myocardial infarction (MI). Three months following MI and 48 hours prior to stem cell injection, gadolinium enhanced cardiac MRI was performed using a 1.5T Siemens scanner. Electroanatomical mapping of the LV was done with a NOGA XP Cardiac Navigation System with Merge software (Biosense Webster, Inc., Diamond Bar, CA). The MRI images were extracted into the NOGA XP; 3-dimensional reconstruction and segmentation of the left ventricular chamber were done using Merge software on the NOGA XP system. EAM and 3-dimensional MRI were merged using manual landmark and automated surface registration. The quality of the merge was assessed as the average distance between the MRI and the EAM, and was 3.6±1.0mm. The merged image was used to guide the transendocardial injection of 200 million MSCs in 15 sites with injections of 0.5mL each, using a NOGA MyoStar catheter. Injection sites were selected in the scar and border zone as identified by the merged unipolar voltage EAM and MRI (Figure 1).   Conclusions:  A three-dimensional MRI reconstruction of the LV can be integrated into a NOGA voltage map to guide transendocardial injections of stem cells; therapeutic guidance with the merged MRI/EAM combines accurate and detailed anatomical information from MRI, with functional information about scarred and viable myocardium from EAM.
ACUTE BACTERIAL ENDOCARDITIS; A CASE REPORT WITH RECOVERY AFTER TREATMENT WITH PENICILLIN
Authors: R J CATALDO
Journal: Annals of Internal Medicine (1946)

Case Reports1 March 1946ACUTE BACTERIAL ENDOCARDITIS; A CASE REPORT WITH RECOVERY AFTER TREATMENT WITH PENICILLINROBERT J. CATALDO, M. D.ROBERT J. CATALDO, M. D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-24-3-479 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe term endocarditis may be defined as an inflammation of the lining membrane of the heart, often peculiarly limited to the valves of the heart, when the term valvulitis may appropriately be applied. In some instances the lesion is relatively slight with limitation to a single valvular cusp, to a small area of the mural endocardium, to a papillary muscle, or the lesion may be only a part of an extensive involvement of the heart, a pancarditis, in which the predominating symptoms and signs may be endocardial, myocardial or pericardial.1For clinical purposes, however, the term endocarditis should be divided...Bibliography1. TICE F: The practice of medicine, Vol. VI, 1943, W. F. Prior Co., Hagerstown, Md., pp. 253-273. Google Scholar2. LEVINE SA: Clinical heart disease, 2nd Edition, 1940, W. B. Saunders Co., Philadelphia. CrossrefGoogle Scholar3. FISHBERG AM: Hypertension and nephritis, 4th Edition, 1937, Lea and Febiger, Philadelphia, pp. 547. Google Scholar4. FUTCHERSCOTT PHVC: Four cases of gonococcal endocarditis treated with sulfonamides, with recovery of one, Bull. Johns Hopkins Hosp., 1939, lxv, 377. Google Scholar5. ORGAINPOSTON ESMA: Gonococcal endocarditis, with recovery after sulfapyridine: Report of a case, New England Jr. Med., 1939, ccxxi, 167. CrossrefGoogle Scholar6. GALBREATHHALL WRE: Sulfonamide therapy of bacterial endocarditis; results in forty-two cases, Ann. Int. Med., 1943, xviii, 201. Google Scholar7. GUERRAPEREZ CAVAL F: Chemotherapy against micro-organisms, penicillin in the treatment of endocarditis, Arch. latino-am. de cardiol. y hemat., 1943, xlii, 25. Google Scholar8. DAWSONHOBBY MHGL: The clinical use of penicillin: observations in 100 cases, Jr. Am. Med. Assoc., 1944, cxxiv, 611. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication March 8, 1945.From the First and Third Medical Services (Tufts), Boston City Hospital, and the Department of Medicine, Tufts College Medical School. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInfective endocarditis in patients with kidney failure: Chronic dialysis and kidney transplantDie septischen Erkrankungen 1 March 1946Volume 24, Issue 3Page: 479-484KeywordsEndocarditisHeartHospital medicineInflammationLesionsMedical servicesMyocardiumPapillary musclesPenicillinSigns and symptoms ePublished: 1 December 2008 Issue Published: 1 March 1946 PDF downloadLoading ...
Abstract 13449: Mitral Annular Disjunction in Patients With Severe Mitral Regurgitation
Authors: Tomoko Tani, Toshiko Konda, Toru Kita, Yutaka Furukawa
Journal: Circulation (2013)

Background: Mitral annular disjunction (MAD) is pathologically defined by a separation between atrial wall-mitral valve (MV) junction and the left ventricular attachment. Methods: We studied 185 co...
A Sweet Source of Abdominal Pain
Authors: John J. Ross, Shari S. Rogal, Chinweike Ukomadu
Journal: New England Journal of Medicine (2011)

A 25-year old woman presented to her primary care physician for evaluation of abdominal pain. Her abdominal discomfort began six months earlier, and was localized to the right upper quadrant. She described a constant pressure unrelated to food intake and associated with intermittent nausea and vomiting. She denied hematochezia, melena, dysphagia, anorexia, increase in abdominal girth . . .
Abstract P404: "Mediterranean" Dietary Pattern for the Primary Prevention of Cardiovascular Disease: A Cochrane Systematic Review
Authors: Karen Rees, Nadine Flowers, Louise Hartley, Aileen Clarke, Margaret Thorogood, Saverio Stranges
Journal: Circulation (2013)

Background: Observational studies have confirmed benefits of adherence to a Mediterranean dietary pattern on CVD risk factors. Clinical trial evidence is limited, mostly in secondary prevention. Ob...
Soundings: The laws of thermodynamics
Authors: Kevin Barraclough
Journal: BMJ (1999)

I was sitting on the end of the old man’s bed listening to stories of his life. I was a medical student at the time. The odd thing, he had said, was that the world made no more sense to him then than it had when he was a boy. He had thought that things would become clearer with age. I remember the perplexity in his watery eyes. Somehow, time had crept up on him before he had sorted things out, before he fully understood what it was all about.

Not long after our talk he arrested, and I watched, mute, as the crash team tried unsuccessfully to resuscitate him. I considered his enigmatic comments as I watched his viscera being examined in the mortuary. But I gave the matter little more thought because I was a young man in a hurry, more concerned with the relationships of the lateral cutaneous nerve of the thigh than with arcane questions of purpose.

In those days patients were distant, frail creatures, far removed from the confident certainty of my own youth. They passed through the wards like shoals of herring, making their presence felt only occasionally by some comment that would flare briefly on the ward round, reminding us of our mutual humanity. But mostly they were cases: mitral stenosis, a third nerve palsy, and we pursued their physical signs like vultures, perched on the end of their beds with our stethoscopes.

And then gradually through time, like some animated Kaplan Meier survival graph, your family, friends, and colleagues slipped off the 100% line, and became part of the shoal. Suddenly the blue, panting old woman in the corner of the ward, with cor pulmonale and the loud second heart sound, is your mother. The man in intensive care with the subarachnoid is your colleague and friend. And the fretful, uncertain parent is you. Uncertain because you are no longer sure that fate will always deal you the best hand in the way that it did when you were immortal.

Before I did medicine I did a degree in physics. I think that medical students should learn more physics. The three laws of thermodynamics are particularly important:

You can’t win.

You can’t break even.

And you can’t even get out of the race.
Coordinate secretion of interleukin-1 beta and granulocyte-macrophage colony-stimulating factor by the blast cells of acute myeloblastic leukemia: role of interleukin-1 as an endogenous inducer
Authors: JC Rodriguez-Cimadevilla, V Beauchemin, L Villeneuve, F Letendre, A Shaw, T Hoang
Journal: Blood (1990)
Abstract 12612: Employing Techniques to Maximize Lesion Contiguity and Transmurality During PV Isolation: Impact on the Durability of Electrical PV Isolation
Authors: Marc A Miller, Srinivas Dukkipati, Jacob Koruth, Andre d'Avila, Vivek Y Reddy
Journal: Circulation (2011)

Background: Durable PV isolation, the cornerstone of AF ablation, has been an elusive goal. Objective: In an attempt to minimize gap-related PV reconnections, we instituted a series of modification...
Trophoblastic Tumours
Authors: K. D. Bagshawe
Journal: BMJ (1963)

This paper reports the results of chemotherapy in patients with trophoblastic tumours during the past five years.Some observations on possible lines of developments in this field are made.A total of 28 patients were seen and 23 were treated.Details of those treated are summarized in Table I.The decision to use chemotherapy was based on all the data available for each patient.In most instances these data were clinical, radiological, hormonal, and histological, but in some patients tumour tissue was not available for histological examination. Classification of Treated PatientsChoriocarcinoma.-A diagnosis of choriocarcinoma was made on material from 12 patients, using the criteria of Novak and Seah (1954).Eleven of these had pulmonary metastases and five also had intracranial metastases.Chorioadenoma Destruens.-Twopatients were classified as having chorioadenoma destruens.One had developed pulmonary metastases six months after hysterectomy.The other had no metastases radiographically but had electro- cardiographic evidence of pulmonary embolism by tumour.Unclassified Trophoblastic Tumours.-Onhistological grounds nine patients could not be classified.The diagnosis in these patients depended essentially on the finding of high gonadotrophin levels in the presence of a disease- complex consistent with tumours of the trophoblast.Seven of these had preceding hydatidiform moles.Six had
A Phase II Study of Weekly Inotuzumab Ozogamicin (InO) in Adult Patients with CD22-Positive Acute Lymphoblastic Leukemia (ALL) in Second or Later Salvage
Authors: Anjali S. Advani, Anthony S. Stein, Hagop M. Kantarjian, Andrei R. Shustov, Daniel J. DeAngelo, Revathi Ananthakrishnan, Katherine Liau, Erik Vandendries, Wendy Stock
Journal: Blood (2014)
Abstract 77: Effects Of Short-term Fasting On Mortality, Inflammatory And Coagulation Responses To Endotoxin-induced Shock In Rats
Authors: Kyoko Kobayashi, Takumi Taniguchi, Ken Yamamoto
Journal: Circulation (2007)

Obesity is a common problem in sepsis. We evaluated the effects of short-term fasting on the mortality rate, inflammatory and coagulation response in rats with endotoxin-induced shock. Male Wister rats (n=30) were used. Animals were randomly assigned to one of two groups: control group (n=15), receiving intravenous Escherichia coli endotoxin (15 mg/kg over 2 mins); fasted group (n=15), short-term fasting for 3 days before endotoxin injection. The mortality rates, hemodynamics, arterial blood gases, plasma cytokine concentrations and coagulation parameters were measured. The mortality rates at 8hrs after endotoxin injection were 75% and 7% for control and fasted groups, respectively. Hypotension and the increases of TNF-alpha and interleukin-6 concentrations were less for the fasted group than the control group. Moreover, the increase of the prothrombin-time and thrombin-antithrombin III complex were less for the fasted group than the control group. The present study showed that short-term fasting inhibited hypotension and elevations in cytokine concentrations, reducing the mortality rate of rats with endotoxin-induced shock. Moreover, short-term fasting inhibited the elevation of coagulation parameters. These findings suggest that short-term fasting may exert favorable effects during sepsis and septic shock. Survival curves for fasted and control groups
Abstract 4564: Use of Adult Dyssynchrony Thresholds in Pediatric Patients Leads to a High False Positive Rate
Authors: Vincent Thomas, Brandon Fornwalt, Carey Lamphier, Derek Fyfe
Journal: Circulation (2008)

Introduction While cardiac resynchronization therapy (CRT) has been successful in adults, translation into pediatrics is complicated. Tissue Doppler echocardiographic assessment of dyssynchrony may help identify children who will benefit from CRT. However, threshold values to diagnose dyssynchrony in pediatric patients have not been defined. We hypothesized that adult tissue Doppler dyssynchrony thresholds would not accurately apply to pediatric patients. We aimed to define new threshold values as necessary. Methods Sixty controls with normal QRS on ECG and 2D echocardiography were enrolled with 20 subjects in each of three age groups: 0 –2, 2–10 and 10 –17 years. Four dyssynchrony parameters were quantified: septal to lateral delay (SLD), peak velocity difference (PVD), SD of the 12 segment model (TsSD), and cross-correlation delay (XCD). Published adult thresholds for each dyssynchrony parameter (60, 65, 34 and 31 msec for SLD, PVD, TsSD and XCD, respectively) were used to calculate false positive rates (i.e. the percentage of normal controls incorrectly diagnosed as dyssynchronous). Results SLD, PVD and TsSD had high false positive rates while XCD did not (Fig A ). The false positive rate for XCD approached 0% with increasing age (Fig B ). The upper limit of normal for XCD defined by mean + 2*SD was 46, 56 and 34 msec for the 0 –2, 2–10 and 10 –17 age groups, respectively. Conclusions Adult tissue Doppler dyssynchrony thresholds for 3 of the most commonly used parameters incorrectly diagnose 57– 85% of normal children as dyssynchronous. Cross-correlation delay shows promise in diagnosing dyssynchrony in children, and new thresholds for younger patients have been developed.