tbuckley/cabot-search huggingface dataset:
Real World Data of Concurrent Arsenic Trioxide and All-Trans Retinoic Acid with Minimal Use of Anthracycline in the Treatment of Acute Promyelocytic Leukemia
Authors: Uday Prakash Kulkarni, Sushil Selvarajan, Sharon Lionel, Mithun Abraham Prakash, Hamenth Kumar Palani, Nithya Balasundaram, Arvind Venkatraman, Anu Korula, Anup J Devasia, Fouzia NA, Nancy Beryl Janet, Sukesh Chandran Nair, Aby Abraham, Thenmozhi Mani, Jeyaseelan Lakshmanan, Arun Kumar Arunachalam, Poonkuzhali Balasubramanian, Biju George, Vikram Mathews
Journal: Blood (2021)
Healthcare Resource Utilization and Costs of Medicare Fee for Service Beneficiaries Newly Diagnosed with Moderate to Severe Non-Advanced Systemic Mastocytosis
Authors: Erin M. Sullivan, Jenna Cohen, Chelsea Norregaard, Uyen Nguyen, Chris Sloan, Allison Petrilla, Alison Silverstein, Anne Murunga, Jill Schinkel
Journal: Blood (2021)
Liver function test abnormalities at hospital admission are associated with severe course of SARS-CoV-2 infection
Authors: S. Weber, J. C. Hellmuth, C. Scherer, M. Muenchhoff, J. Mayerle, A. L. Gerbes
Journal: Gut (2021)

Objective Liver injury has frequently been reported in COVID-19 patients. The clinical relevance of liver injury related to SARS-CoV-2 infection remains unclear with a need for prospective studies on the impact of liver function test (LFT) abnormalities at baseline. Design Data of 217 patients without pre-existing liver disease prospectively included in the COVID-19 registry of the LMU university hospital were analysed in order to assess the association of abnormal LFT at admission and course of the disease. Severe course was defined as admission to the intensive care unit (ICU) or as COVID-19-related death. Results Abnormal LFT at baseline was present in 58% of patients, with a predominant elevation of aspartate aminotransferase (AST) (42%), gamma-glutamyltransferase (GGT) (37%) and alanine aminotransferase (ALT) (27%), hypoalbuminaemia was observed in 33%. Elevation of ALT and GGT, as well as hypoalbuminaemia, was associated with higher proportions of patients requiring ICU treatment and mechanical ventilation. After adjusting for age, gender and comorbidities, hypoalbuminaemia combined with abnormal AST or GGT at hospital admission was a highly significant independent risk factor for ICU admission (OR 46.22 and 38.8, respectively) and for a composite endpoint of ICU admission and/or COVID-19-related death (OR 42.0 and 26.9, respectively). Conclusion Abnormal LFTs at hospital admission, in particular GGT and albumin, are associated with a severe course of SARS-CoV-2 infection.
Bendamustine Is a Safe and Effective Regimen for Lymphodepletion before Tisagenlecleucel in Patients with Large B-Cell Lymphomas
Authors: Guido Ghilardi, Elise A Chong, Jakub Svoboda, Philipp Wohlfarth, Sunita Dwivedy Nasta, Staci Williamson, Daniel J Landsburg, James N Gerson, Stefan K. Barta, Raymone Pajarillo, Jessie Myers, Rebecca Yelton, Hatcher J. Ballard, Shannon H Gier, Danielle Victoriano, Elizabeth Weber, Ellen Napier, Simon F Lacey, Alfred L. Garfall, David L Porter, Ulrich Jaeger, Richard T. Maziarz, Marco Ruella, Stephen J Schuster
Journal: Blood (2021)
Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells
Authors: Valdenizia R. Silva, Luciano de S. Santos, Rosane B. Dias, Claudio A. Quadros, Daniel P. Bezerra
Journal: Cancer Communications (2021)

Abstract Colorectal cancer (CRC) represents the third most commonly diagnosed cancer and the second leading cause of cancer death worldwide. The modern concept of cancer biology indicates that cancer is formed of a small population of cells called cancer stem cells (CSCs), which present both pluripotency and self‐renewal properties. These cells are considered responsible for the progression of the disease, recurrence and tumor resistance. Interestingly, some cell signaling pathways participate in CRC survival, proliferation, and self‐renewal properties, and most of them are dysregulated in CSCs, including the Wingless (Wnt)/β‐catenin, Notch, Hedgehog, nuclear factor kappa B (NF‐κB), Janus kinase/signal transducer and activator of transcription (JAK/STAT), peroxisome proliferator‐activated receptor (PPAR), phosphatidyl‐inositol‐3‐kinase/Akt/mechanistic target of rapamycin (PI3K/Akt/mTOR), and transforming growth factor‐β (TGF‐β)/Smad pathways. In this review, we summarize the strategies for eradicating CRC stem cells by modulating these dysregulated pathways, which will contribute to the study of potential therapeutic schemes, combining conventional drugs with CSC‐targeting drugs, and allowing better cure rates in anti‐CRC therapy.
A Phase I Study of Pevonedistat, Azacitidine and Venetoclax for Patients with Relapsed/Refractory Acute Myelogenous Leukemia (AML)
Authors: Guru Subramanian Guru Murthy, Scott H. Kaufmann, Aniko Szabo, Alexandra M. Harrington, Laura C. Michaelis, Sameem Abedin, Karen Carlson, Lyndsey Runaas, Walter L. Longo, Alexander Hinman, Sonia Maldonado-Schmidt, Althea Thomas, Arielle Baim, Mark R. Litzow, Ehab L. Atallah
Journal: Blood (2021)
Efficacy and Safety of Hematopoietic Stem Cell Transplantation <i>Vs</i>. Immunosuppressive Therapy in Patients with Hepatitis-Associated Aplastic Anemia: A Single-Center Cohort Study and Meta-Analysis
Authors: Yaonan Hong, Yuzhu Li, Qi Liu, Huijie Dong, Wenbin Liu, Huijin Hu, Yingying Shen, Shengyun Lin, Shan Liu, Dijiong Wu
Journal: Blood (2021)
Abstract 12447: Early-Stage, Community-Based Design Process to Understand User Needs for Hypertension Management mHealth Intervention: The WIRED-L Study
Authors: Maria Cielito Robles, Linde Huang, Beza Merid, Aalap Doshi, Soo Ji Choi, Chris Kurien, Mark Newman, Michael Dorsch, Brahmajee K Nallamothu, Lesli E Skolarus
Journal: Circulation (2021)

Background: Black Americans and older adults have high rates of hypertension and face unique barriers to managing their blood pressure. Using a community-based participatory design approach, we sought out to understand such barriers and determinants for engaging in a healthy lifestyle to inform the development of a wearables-based mHealth intervention. Methods: As part of the Wearables In Reducing risk and Enhancing Daily Life-style (WIRED-L) study, we performed semi-structured discovery interviews of hypertensive adults in Flint and Ann Arbor, MI that relied on the capability, opportunity and motivation behavior (COM-B) framework focusing on 2 behaviors: 1) increase physical activity and 2) decrease salt intake. A rapid analysis approach was used to analyze interview data. Transcripts were used as artifacts for the subsequent empathy mapping session, attended by academic partners and community participants, to contextualize the discovery interviews. Results were compared across study sites. Results: We conducted 9 discovery interviews (Flint = 4 Black people; Ann Arbor = 3 White and 2 Asian people). Physical capability (i.e. pain and disability) and automatic motivation (i.e. habits and drive) were barriers for physical activity, while psychological capability (i.e. understanding), automatic and reflective motivations (i.e. plans and evaluations) were barriers for healthy eating. From empathy mapping that included 12 stakeholders, the primary insight for the Flint user group was a desire to decrease salt intake, but practical constraints exist (e.g., unhealthy foods are the cheaper option, and price is an important factor in health decisions). In the Ann Arbor user group, participants were comfortable with navigating technology and had environments more conducive for physical activity. Conclusion: User groups faced different challenges to maintaining a healthy lifestyle. To reduce hypertension disparities, our design will focus on the barriers that were more prevalent among the Flint population. Our results suggest reducing racial disparities in hypertension will require addressing all phases of mHealth intervention development.
Real-World Analysis of the Clinical and Economic Burden of Later Line in Chronic Myeloid Leukemia Patients in Italy
Authors: Massimo Breccia, Francesca Chiodi, Diletta Valsecchi, Valentina Perrone, Diego Sangiorgi, Elisa Giacomini, Maria Chiara Rendace, Paola Coco, Eleonora Premoli, Luca Degli Esposti
Journal: Blood (2021)
Inferior Outcomes for Multiple Myeloma (MM) Patients (pts) Harbouring t(11;14) and the Promise of Venetoclax, Real-World Australian Retrospective
Authors: Kenneth JC Lim, Dipti Talaulikar, Joanne L C Tan, Joanna Loh, Pratheepan Puvanakumar, James Anton Kuzich, Michelle Ho, Matthew Murphy, Nicole Zeglinas, Sue Morgan, Michael S.Y. Low, David Routledge, Andrew B M Lim, Simon D. Gibbs, Slavisa Ninkovic
Journal: Blood (2021)
Phase 3, Open-Label, Randomized Study of Gilteritinib and Azacitidine Vs Azacitidine for Newly Diagnosed <i>FLT3</i>-Mutated Acute Myeloid Leukemia in Patients Ineligible for Intensive Induction Chemotherapy
Authors: Eunice S. Wang, Pau Montesinos, Mark D. Minden, Je-Hwan Lee, Michael Heuser, Tomoki Naoe, Wen-Chien Chou, Kamel Laribi, Jordi Esteve, Jessica K. Altman, Violaine Havelange, Anne-Marie Watson, Elzbieta Patkowska, Shufang Liu, Ruishan Wu, Nisha Philipose, Jason E. Hill, Stanley Gill, Elizabeth Shima Rich, Ramon V. Tiu
Journal: Blood (2021)
Abstract 9046: Effects of Acute Doses of Cocaine on Arterial Left Ventricular Coupling and Left Ventricular Mechanical Efficiency in Conscious, Chronically-Instrumented Dogs
Authors: Che Ping Cheng, Xiaowei Zhang, Tiankai Li, Zhi Zhang, Xiaoqiang Sun, Jing Cao, David M Herrington, David Zhao, Heng Cheng
Journal: Circulation (2021)

Background: Cocaine, one of the most commonly used illegal drugs, exaggerates sympathetic nervous activity and has profound effects on the cardiovascular system. It is well known that acute doses of cocaine raise the heart rate, and cause acute hypertension, arrhythmia, and reduce coronary blood flow. However, its role and mechanism on the arterial-left ventricular (LV) coupling (ALVC) and LV mechanical efficiency remain to be critically examined. We hypothesized cocaine may impair ALVC and produce myocardial contractile and metabolic abnormalities, and thus impair LV ability to convert metabolic energy to external work. Methods: We examined the effect of cocaine (4 mg/kg/iv) on ALVC and the conversion of metabolic energy [measured as myocardial oxygen consumption (MVO 2 )] to mechanical work [measured as pressure (P)-volume (V) area (PVA)], and PVA to external work (SW) in 6 conscious chronically instrumented dogs. The control MVO 2 -PVA relation was generated by altering loading conditions using three graded doses of Phenylephrine after autonomic blockade with hexamethonium and atropine. Results: Ten minutes after cocaine administration, blood cocaine level was 7.3±2.4 mg/L. There were significant decreases in the slope (E ES ) of LV end-systolic P-V relation (5.0±0.09 vs 6.7±1.4 mmHg/ml, p&lt;0.05), SW (1379±284 vs 1739±204 mmHg•ml, p&lt;0.05) and increases in arterial elastance (E A ) (13.6±2.6 vs 7.6±1.8 mmHg•ml, p&lt;0.05). Despite the decrease in E ES , energy utilization as calculated from LV MVO 2 was increased (0.13±0.01 vs 0.10±0.02 ml O 2 /beat/100g LV, p&lt;0.01) and the MVO 2 -PVA point was shifted above the control MVO 2 -PVA relation by 0.010±0.002 ml O 2 /beat/100g LV, (p&lt;0.05). The SW/PVA ratio decreased (56±8% vs 75±12%, p&lt;0.05) as impaired arterial-LV coupling indicated by a significantly increased the ratio of E A to E ES (from 1.2±0.4 of baseline to 2.8±0.05 after cocaine (p&lt;0.05). Thus, SW/MVO 2 , representing LV mechanical efficiency, decreased from 11.0±1.9 to 8.8±1.2% (p&lt;0.05) with cocaine. Conclusions: Acute doses of cocaine impair arterial LV coupling and decrease LV mechanical efficiency due to the decreased conversion of mechanical energy (PVA) to external work (SW) which mainly resulted from the deterioration of arteria-LV coupling.
Lymphoma during Pregnancy: A Multicentre Study By the Australasian Lymphoma Alliance
Authors: Pietro R Di Ciaccio, Belinda Campbell, Kylie D Mason, Mohamed Shanavas, Matthew Greenwood, Gareth P Gregory, Renee Eslick, Giselle Kidson-Gerber, Catherine Tang, Kirk L Morris, Portia Smallbone, Xavier Badoux, Michael J Shipton, Sean J McKeague, Jenna Langfield, Kathryn Goss, Nada Hamad
Journal: Blood (2021)
Significance of Degree of HLA Disparity When Using Haploidentical Donors with T-Replete PBSC and Post-Transplantation Cyclophosphamide (PTCy) in Acute Myeloid Leukemia (AML) in First Complete Hematologic Remission (CR1)
Authors: Mohamed A. Kharfan-Dabaja, Myriam Labopin, Ernesto Ayala, Ali Bazarbachi, Didier Blaise, Yener Koc, Jan Vydra, Alessandro Busca, Luca Castagna, Yana Novis, Andrew McDonald, Claude-Eric Bulabois, Christoph Schmid, Concepcion Herrera Arroyo, Edouard Forcade, Fabio Ciceri, Jaime Sanz, Arnon Nagler, Mohamad Mohty
Journal: Blood (2021)
NINE CASES OF ERYTHEMA NODOSUM
Authors: R. H. Parry, E. J. Parry
Journal: BMJ (1929)

ERYTHEMA NODOSUM.he was invalided as a consequence, and written down as 112.From that time to the present he has been bothered at intervals by bright lights, but otherwise has had no particular trouble until July, 1928, when both corneae developed small deep ulcers, which showed little staining with fluorescein.Since then his trouble has slowly progressed, until on November 22nd, 1928, the condition of the eyes was as follows.Extending across the cornea of the right eye from side to side, and beyond it on each side, invading the sciera for a short distance; was a deep, gutter-like excavation of the corneal tissue (Fig. 2,C).The edges had a somewhat rolled appear anice, and
Successful resection of protruding tumor with muscle-retracting sign during rectal endoscopic submucosal dissection using isolation method and picking technique with clutch cutter
Authors: Satoshi Abiko, Koji Hirata, Kazuharu Suzuki, Kenji Kinoshita, Kazuteru Hatanaka, Yoshiya Yamamoto, Hirohito Naruse
Journal: Endoscopy (2021)

Endoscopic submucosal dissection (ESD) has become widely used for treatment of colorectal tumors, but there are resections of protruding tumors with the muscle-retracting sign of the ESD procedure that are still difficult to manage [1]. The usefulness of a clutch cutter, a scissor-type knife, for colorectal ESD has recently been reported [2] [3]. Here we report successful resection of a protruding tumor with the muscle-retracting sign during rectal ESD using an isolation method and picking technique with a clutch cutter.
Donor Lymphocyte Infusion Is a Feasible Way to Improve Survival in Patients with Acute Myeloid Leukemia and Myelodysplastic Syndromes Who Relapse after Allogeneic Stem Cell Transplantation
Authors: Lia Minculescu, Joanne Reekie, Søren Lykke Petersen, Brian Thomas Kornblit, Ida Schjødt, Niels Smedegaard Andersen, Lisbeth Pernille Andersen, Anne Fischer-Nielsen, Eva Kannik Hastrup, Lone Smidstrup Friis, Henrik Sengeloev
Journal: Blood (2021)
Abstract 9332: A Case of Fulminant Vasculitis Complicated by ST-Elevation Myocardial Infarction and Stroke
Authors: Vy A Pham, Christopher P Kovach, Karl Gordon Patti, Evan S Manning, Stephen J Slade, Rebecca Pollard, Elena Weinstein, Jennifer Simpson, James E carter
Journal: Circulation (2021)

Introduction: Acute coronary syndrome is a rare complication of vasculitis. We present a case of fulminant medium-vessel vasculitis complicated by ST-elevation myocardial infarction (STEMI) and stroke. Case report: A 30-year-old woman with a history of painful skin lesions presented with acute headache, neck pain, and right arm weakness with paresthesia. CT angiography revealed high-grade stenosis of the internal carotids. Subsequently, she reported acute chest pain and dyspnea. ECG revealed anterior STEMI (Figure 1). She underwent emergent coronary angiography that revealed an acute occlusive thrombus of the proximal LAD that was successfully treated with aspiration thrombectomy and drug-eluting stent deployment (Figure 1). The patient was transferred to our institution with concern for fulminant vasculitis complicated by STEMI and stroke. Upon arrival to our hospital, CT and MRI revealed severe occlusions of the bilateral internal carotid arteries and a left middle cerebral artery infarct (Figure 1). Echocardiogram demonstrated severe left ventricular systolic dysfunction with regional wall motion abnormalities. Additional imaging demonstrated inflammation of the thoracic aorta, common iliac, and renal arteries, as well as occlusions of the inferior mesenteric and infratibial arteries. An extensive serologic evaluation for rheumatologic disease was negative. The patient was treated with IV corticosteroids and cyclophosphamide for fulminant medium-vessel vasculitis. Discussion: This report provides a rare opportunity to consider the management of fulminant vasculitis, most likely polyarteritis nodosa, presenting as STEMI and acute stroke. The patient’s presentation, imaging, and laboratory findings were inconsistent with alternative diagnoses such as Tayakasu’s arteritis, Behçet’s disease, or a systemic rheumatologic condition. The patient improved with immunosuppression and follows with cardiology for chronic heart failure.
Manipulation of Fatty Acid Metabolism Impairs Megakaryocyte Differentiation and Platelet Production
Authors: Maria N. Barrachina, Gerard Pernes, Isabelle C Becker, Dafna Groeneveld, James P. Luyendyk, Peter J Meikle, Graeme I Lancaster, Andrew J Murphy, Kellie Machlus
Journal: Blood (2021)
Transcriptional Immunoediting of AML Cells after Allogeneic Hematopoietic Stem Cell Transplantation
Authors: Kenneth Eagle, Taku Harada, Jeremie Kalfon, Monika Perez, Yaser Heshmati, Jazmin Ewers, Kimberly Stegmaier, Stuart H. Orkin, Maxim Pimkin
Journal: Blood (2021)
Comparative Study of Haiti and Miami Cohorts of Sickle Cell Disease (CSHSCD): Methods, Accomplishments, and Implementation
Authors: Ofelia A. Alvarez, Tally Hustace, Emmeline Lerebours, Nora St Victor Dely, Rony Saint Fleur, Emanise Muscadin, Ulrick Liberus, Paulonne Bien-Aime, Alejandro Mantero, Eric R. Brown, Louis Herns Marcelin, Ronald Eveillard, Michele Paul-Hanna, Nelly Campo, Iszet Campo-Bustillo, Jose Romano
Journal: Blood (2021)
TP-0184, a Novel FLT3-ALK2 Dual Inhibitor, Targets Amino Acid Transport and Biosynthesis in AML Cells and Sensitizes AML Cells to Chemotherapy and BCL2 Inhibition
Authors: Anudishi Tyagi, Stanley Ly, Bin Yuan, Fouad El-Dana, Appalaraju Jaggupilli, Jason M Foulks, Steven L. Warner, Venkata Lokesh Battula
Journal: Blood (2021)
Abundance of B Cell Receptors Harboring Elongated Polytyrosine and Polyserine Rich Motifs within Their Heavy Chain CDR3 Distinguishes Catastrophic and Antiphospholipid Syndrome
Authors: Shadi Swaidani, Shruti Chaturvedi, Xiang-Zuo Pan, Robert Brodsky, Renren Wen, Alok A Khorana, Keith R. McCrae
Journal: Blood (2021)
Abstract 13450: Role of PKC in Metabolic Regulation of Endothelial SK Channels
Authors: Hang Xing, Guangbin Shi, Yuhong Liu, Frank W Sellke, Jun Feng
Journal: Circulation (2021)

Introduction: Diabetes is associated with increases in metabolites NADH, and PKC. NADH has been recently found to inactivate endothelial SK channels. Overexpressed and activated PKC has been shown to play an important role in diabetes-induced endothelial dysfunction. However, it is undefined if PKC is involved in the NADH dysregulation of endothelial SK channels. Hypothesis: We hypothesized that PKC in a signaling cascade whereby NADH dysregulates endothelial SK channels and coronary relaxation function. Methods: SK channel currents of human coronary artery endothelial cells were measured by whole-cell patch-clamp method in the presence or absence of NADH, and/or PKC activator PMA, or PKC inhibitors or endothelial PKC α /PKC β knock-down by using short interfering RNA. The in-vitro coronary arterioles (n = 5) from the harvested atrial tissue samples of patients undergoing cardiac surgery were perfused with NADH in the presence or absence of PKC β inhibitor LY333531. Vascular reactivity was measured by vessel myography in the presence of vasoconstrictor and vasodilators. Results: NADH (30-300μM, n=7-9) or PKC activator PMA (30-300μM, n=6-12) reduced endothelial SK current density (p&lt;0.05 vs. control (n=15), Fig. A-D), whereas the selective PKC β inhibitor LY333531 (50nM, n=12) significantly reversed the NADH-induced SK channel inhibition (p&gt;0.05 vs. control (n=15), Fig. E). PKC α knock-down failed to affect NADH (n=13) and PMA (n=10) inhibition of endothelial SK currents (Fig. F). In contrast, PKC β knock-down significantly prevented NADH (n=12) and PMA (n=6)-induced SK inhibition (p&gt;0.05, vs. control, Fig. G). Incubation of vessels with NADH significantly reduced relaxation response to the SK activator NS309 and this effect was abolished in the presence of LY333531. Conclusions: The metabolite NADH dysregulation of endothelial SK channels and impairment of endothelium-dependent relaxation function was via the PKC β signaling pathway.
Multi-Institutional Validation of a Mammography-Based Breast Cancer Risk Model
Authors: Adam Yala, Peter G. Mikhael, Fredrik Strand, Gigin Lin, Siddharth Satuluru, Thomas Kim, Imon Banerjee, Judy Gichoya, Hari Trivedi, Constance D. Lehman, Kevin Hughes, David J. Sheedy, Lisa M. Matthis, Bipin Karunakaran, Karen E. Hegarty, Silvia Sabino, Thiago B. Silva, Maria C. Evangelista, Renato F. Caron, Bruno Souza, Edmundo C. Mauad, Tal Patalon, Sharon Handelman-Gotlib, Michal Guindy, Regina Barzilay
Journal: Journal of Clinical Oncology (2021)

Accurate risk assessment is essential for the success of population screening programs in breast cancer. Models with high sensitivity and specificity would enable programs to target more elaborate screening efforts to high-risk populations, while minimizing overtreatment for the rest. Artificial intelligence (AI)-based risk models have demonstrated a significant advance over risk models used today in clinical practice. However, the responsible deployment of novel AI requires careful validation across diverse populations. To this end, we validate our AI-based model, Mirai, across globally diverse screening populations.We collected screening mammograms and pathology-confirmed breast cancer outcomes from Massachusetts General Hospital, USA; Novant, USA; Emory, USA; Maccabi-Assuta, Israel; Karolinska, Sweden; Chang Gung Memorial Hospital, Taiwan; and Barretos, Brazil. We evaluated Uno's concordance index for Mirai in predicting risk of breast cancer at one to five years from the mammogram.A total of 128,793 mammograms from 62,185 patients were collected across the seven sites, of which 3,815 were followed by a cancer diagnosis within 5 years. Mirai obtained concordance indices of 0.75 (95% CI, 0.72 to 0.78), 0.75 (95% CI, 0.70 to 0.80), 0.77 (95% CI, 0.75 to 0.79), 0.77 (95% CI, 0.73 to 0.81), 0.81 (95% CI, 0.79 to 0.82), 0.79 (95% CI, 0.76 to 0.83), and 0.84 (95% CI, 0.81 to 0.88) at Massachusetts General Hospital, Novant, Emory, Maccabi-Assuta, Karolinska, Chang Gung Memorial Hospital, and Barretos, respectively.Mirai, a mammography-based risk model, maintained its accuracy across globally diverse test sets from seven hospitals across five countries. This is the broadest validation to date of an AI-based breast cancer model and suggests that the technology can offer broad and equitable improvements in care.
Consistent safety profile with up to 5 years of continuous treatment with guselkumab: Pooled analyses from the phase 3 VOYAGE 1 and VOYAGE 2 trials of patients with moderate-to-severe psoriasis
Authors: Andrew Blauvelt, Tsen-Fang Tsai, Richard G. Langley, Megan Miller, Yaung-Kaung Shen, Yin You, Ya-Wen Yang, Kim A. Papp, Luis Puig
Journal: Journal of the American Academy of Dermatology (2021)
Updated Results of the Alta Study, a Phase 1/2 Study of Giroctocogene Fitelparvovec (PF-07055480/SB-525) Gene Therapy in Adults with Severe Hemophilia a
Authors: Nathan Visweshwar, Thomas J. Harrington, Andrew D Leavitt, Barbara A. Konkle, Adam Giermasz, Kimo Stine, Jeremy Rupon, Gregory Di Russo, Li-Jung Tseng, Maria de los Angeles Resa, Florence Ganne, Delphine Agathon, Frank Plonski, Didier Rouy, Bettina M. Cockroft, Annie Fang, Steven Arkin
Journal: Blood (2021)