tbuckley/cabot-search huggingface dataset:
Biopharmaceutical nanoclusters: Towards the self-delivery of protein and peptide therapeutics
Authors: Mia Danielsen, Casper Hempel, Thomas L. Andresen, Andrew J. Urquhart
Journal: Journal of Controlled Release (2022)

Protein and peptide biopharmaceuticals have had a major impact on the treatment of a number of diseases. There is a growing interest in overcoming some of the challenges associated with biopharmaceuticals, such as rapid degradation in physiological fluid, using nanocarrier delivery systems. Biopharmaceutical nanoclusters (BNCs) where the therapeutic protein or peptide is clustered together to form the main constituent of the nanocarrier system have the potential to mimic the benefits of more established nanocarriers (e.g., liposomal and polymeric systems) whilst eliminating the issue of low drug loading and potential side effects from additives. These benefits would include enhanced stability, improved absorption, and increased biopharmaceutical activity. However, the successful development of BNCs is challenged by the physicochemical complexity of the protein and peptide constituents as well as the dynamics of clustering. Here, we present and discuss common methodologies for the synthesis of therapeutic protein and peptide nanoclusters, as well as review the current status of this emerging field.
GASTROINTESTINAL BLEEDING AND ENDOSCOPIC FINDINGS IN CRITICALLY AND NON-CRITICALLY ILL PATIENTS WITH COVID-19: RESULTS FROM LEOSS AND COKA REGISTRIES
Authors: S. Zellmer, F. Hanses, A. Muzalyova, J. Classen, G. Braun, C. Piepel, J. Erber, L. Pilgram, L. Walter, S. Göpel, M. Hower, M.M. Rüthrich, M. Stecher, C. Jakob, C. Dhillon, H. Messmann, A. Ebigbo, C. Römmele
Journal: Endoscopy (2022)

Aims COVID-19 patients are at increased risk for thromboembolic events. It is unclear whether the risk for gastrointestinal (GI) bleeding is also increased.
INFLUENCE OF AN ARTIFICIAL INTELLIGENCE (AI) BASED DECISION SUPPORT SYSTEM (DSS) ON THE DIAGNOSTIC PERFORMANCE OF NON-EXPERTS IN BARRETT´S ESOPHAGUS RELATED NEOPLASIA (BERN)
Authors: M. Meinikheim, R. Mendel, M.W. Scheppach, A. Probst, F. Prinz, T. Schwamberger, J. Schlottmann, S.K. Gölder, B. Walter, I. Steinbrück, C. Palm, H. Messmann, A. Ebigbo
Journal: Endoscopy (2022)

Aims Barrett´s esophagus related neoplasia (BERN) is difficult to detect and characterize during endoscopy, even for expert endoscopists. We aimed to assess the add-on effect of an Artificial Intelligence (AI) algorithm (Barrett-Ampel) as a decision support system (DSS) for non-expert endoscopists in the evaluation of Barrett’s esophagus (BE) and BERN.
IMPACT OF PROPHYLACTIC STENT INSERTION INTO THE COMMON BILE DUCT DURING ERCP ON BILIARY COMPLICATION RATE PRIOR CHE: A SINGLE-CENTER RETROSPECTIVE ANALYSIS
Authors: A. Herner, J.R. Wiesner, S.C. Nennstiel, M. Abdelhafez, C. Schlag
Journal: Endoscopy (2022)

Aims ERC with stone removal out of the CBD is generally followed by CHE. Recurrent biliary complications prior CHE can occur and thus immediate CHE should be aimed as recommended in current guidelines. However, in clinical practice CHE is still often postponed. In this scenario prophylactic biliary stenting until CHE might be beneficial.
SOCIOECONOMIC STATUS AND THE ODDS OF INCOMPLETE COLONOSCOPY IN COLORECTAL CANCER SCREENING
Authors: B. Skau Jørgensen, U. Deding, L. Kaalby Møller, G. Baatrup, M. Kobaek-Larsen, I. Al-Najami
Journal: Endoscopy (2022)

Aims Eight percent of colonoscopies performed in the Danish Colorectal Cancer Screening Program are incomplete. Our aim was to investigate the association between socioeconomic status (SES) and incomplete colonoscopy (IC) in the Screening Program.
INTRADIVERTICULAR BARRETT'S ESOPHAGUS ABLATION WITH CHANNEL RADIOFREQUENCY ENDOSCOPIC CATHETER
Authors: N. Torres Monclus, I. Miguel Salas, G. Torres Vicente, D. Bayas Pastor, D. Vazquez Gomez, E. Pijoan Comas, N. Zaragoza Velasco, F. Gonzalez-Huix Llado
Journal: Endoscopy (2022)

A 75-year-old man diagnosed with Barrett's C3M7 esophagus which practically extends entirely inside a distal esophageal diverticulum. Two radiofrequency sessions were performed using a 360º circumferential ablation catheter and a third session using a 90º focal ablation catheter. There was evidence of persistence of focal lesions in the intra diverticular area. We used a catheter inserted through the endoscope channel with a 90º flexible blade, which allowed the access to all the walls of the diverticulum. After a single radiofrequency session with this catheter, complete ablation of the metaplasia within the diverticulum was achieved.
Reopenable clip over line method for the closure of full-thickness defect after gastric endoscopic full-thickness resection
Authors: Tatsuma Nomura, Shinya Sugimoto, Haruka Nakamura, Taishi Temma, Jun Oyamada, Keiichi Ito, Makoto Kobayashi
Journal: Endoscopy (2022)

In recent years, the efficacy of endoscopic full-thickness resection for submucosal tumors has been reported [1] [2]. However, a reliable closure method for large full-thickness defects in the stomach remains unclarified. We developed the reopenable clip over line method for closing the mucosal defect after endoscopic submucosal dissection using reopenable clips and a line placed at the muscle layer and edge of the mucosal defect [3] [4] [5]. We report a new method of this type of closure of a 25-mm full-thickness defect in a porcine model ([Video 1]).
IS PREVIOUS SPHINCTEROTOMY REQUIRED BEFORE PLACEMENT OF A BILIARY COVERED SEMS?
Authors: J.J. Vila, N. Hervas, I. Rodriguez Mendiluce, A. Arrubla, L. Uribarri, V. Jusue, J. Carrascosa, F. Estremera, I. Areste, V. Busto, J. Urman
Journal: Endoscopy (2022)

Aims Our aim was to assess the safety of transpapillary covered stent (CSEMS) placement without previous sphincterotomy.
No question: Proton therapy is safe
Authors: Daniel J Indelicato
Journal: Neuro-Oncology (2022)

Journal Article No question: Proton therapy is safe Get access Daniel J Indelicato Daniel J Indelicato Department of Radiation Oncology, University of Florida College of Medicine, Jacksonville, Florida, USA Corresponding Author: Daniel J. Indelicato, MD, Department of Radiation Oncology, University of Florida College of Medicine, 2015 North Jefferson Street, Jacksonville, FL 32206, USA (dindelicato@floridaproton.org). https://orcid.org/0000-0001-5765-1873 Search for other works by this author on: Oxford Academic PubMed Google Scholar Neuro-Oncology, Volume 24, Issue 9, September 2022, Pages 1582–1583, https://doi.org/10.1093/neuonc/noac121 Published: 06 May 2022 Article history Published: 06 May 2022 Corrected and typeset: 27 May 2022
ASSESSMENT OF RISK VARIABLES AND MORBIDITY IN PATIENTS WITH CIRRHOTIC WITH ASSOCIATED PORTAL VEIN THROMBOSIS IN A SINGLE ASIAN CENTRE -A OBSERVATIONAL STUDY
Authors: S. Sebastian, J. Roy, B. Sebastian, S.K Mathai
Journal: Endoscopy (2022)

Aims To Study was done to determine the various risk factors and prognostic factors of newly detected portal vein Thrombosis(PVT) in Cirrhotics. In hospital complications and short term mortality were also followed up .
TOWARDS AUTOMATIC DETECTION IN PANCREATIC EUS: AN ASSESSMENT OF DEEP LEARNING METHODS
Authors: L. Sosa-Valencia, A. Fleurentin, A. Meyer, J. Montanelli, J.-P. Mazelier, L. Swanstrom, B. Gallix, G. Exarchakis, N. Padoy
Journal: Endoscopy (2022)

Aims Pancreatic cancer is rarely detected at its early stages, when it’s curable, which leads to high mortality rates. Endoscopic ultrasound (EUS) is the best technique available nowadays to detect pancreatic cancer lesions smaller than 10 mm, which are amenable for surgical resection and
DISCONNECTION OF SPIRAL OVERTUBE: AN INFREQUENT COMPLICATION OF MOTORIZED SPIRAL ENTEROSCOPY
Authors: R. Muñoz Pérez, L. Compañy Catalá, F. Ruiz Gómez, A. Rodríguez Angulo, L. Guilabert Sanz, E. Álvarez Arroyo, L. Medina Prado, J. Martínez Sempere, B. Martínez Moreno, C. Mangas Sanjuán, J.R. Aparicio Tormo
Journal: Endoscopy (2022)

A 91-year-old man with suspected small bowel lymphoma underwent anterograde motorized spiral enteroscopy, identifying a stenosing lesion with features of lymphoma in jejunum. Biopsies and tattooing proximal to the lesion were performed. During withdrawal we realized that the overtube was embedded in oesophagus. With an inflated 20mm dilatation balloon partial removal was achieved, being completely removed with Magill forceps. An extensive laceration in oesophagus was treated with hemoclips with good results.
233P Breast cancer organoids mimic disease heterogeneity, allow high-throughput drug screening and show correlation with clinical response
Authors: Z. Dantes, A. Manjunath, L. Ferreira, J. Slawska, K. Steiger, N. Pfarr, K. Bernlochner, B. Hefel, L. Huang, M. Jesinghaus, R. Rosell, M. Kiechle, M. Dantes, K. Lindner, C. Peschel, W. Weichert, S. Paepke
Journal: Annals of Oncology (2022)
225P Impact of potential drug-drug interactions (PDDI) on adherence to endocrine therapy (ET) among patients with breast cancer (BC) in the Health Improvement Network (THIN)
Authors: E. Rassy, A. Bardet, O. Bougacha, L. Gantzer, B. Lekens, I.V. Luis, S. Delaloge, F. André, S. Michiels, B. Pistilli
Journal: Annals of Oncology (2022)
Chemoreflex and Baroreflex Sensitivity Hold a Strong Prognostic Value in Chronic Heart Failure
Authors: Alberto Giannoni, Francesco Gentile, Francesco Buoncristiani, Chiara Borrelli, Paolo Sciarrone, Jens Spiesshoefer, Francesca Bramanti, Giovanni Iudice, Shahrokh Javaheri, Michele Emdin, Claudio Passino
Journal: JACC Heart Failure (2022)
229P Efficiency of SARS-CoV-2 vaccines in breast cancer patients: Single institutional experience from Institute for Oncology and Radiology of Serbia (IORS)
Authors: O.I. Djurmez, M.D. Calamac, M. Dimitrijevic, J.G. Vukosavljevic, K. Serovic, J. Oblakovic-Babic, N.S. Stanic, I.Z. Minic, Z. Tomasevic, I. Bozovic Spasojevic
Journal: Annals of Oncology (2022)
DYSPHAGIA: CLINICAL MANIFESTATIONS AND ETIOLOGICAL PROFILE (ABOUT 290 CASES) MOROCCAN CENTER EXPERIENCE
Authors: H. Aouroud, M. Aouroud, A. Ait Errami, S. Oubaha, Z. Samlani, K. Krati
Journal: Endoscopy (2022)

Aims Dysphagia is a common health problem for consultation in gastroenterology. It is considered to be an alarm symptom requiring the use of endoscopy regardless of the clinical presentation.
“GASTRIC METASTASIS, A RARE SITE OF BREAST CANCER METASTASIS”
Authors: E.C. Abad Izquierdo, B. Tormo Lanseros, D. De Frutos Rosa, G.T. Vazquez Benitez, J.L. Calleja Panero
Journal: Endoscopy (2022)

63-year-old woman with a history of invasive lobular breast cancer. Bone marrow and bone metastasis were identified. A follow-up PET-CT showed an increase uptake in known bone lesions.
A NEW ENDOSCOPIC CLASSIFICATION SCORE SYSTEM FOR SERRATED ADENOMAS IN THE COLORECTUM – THE EUROPEAN SERRATED POLYP CLASSIFICATION SCORE (ESCO)
Authors: P. Klare, F. Kainz, B. Haller, T. Rath, S. Yamamoto, R.M. Schmid
Journal: Endoscopy (2022)

Aims Several attempts have been established for optical classification of colorectal polyps, yet prediction to distinguish between sessile serrated lesions (SSL), adenomas and hyperplastic polyps remains uncertain. The aim of this study was to develop and validate a new endoscopic classification (ESCO) to differentiate between said polyp classes.
ARE BIOMARKERS IN PANCREATIC JUICE USEFUL TO DIFFERENTIATE BETWEEN CHRONIC PANCREATITIS AND IPMN WITH MAIN DUCT INVOLVEMENT?
Authors: S.A. Hoogenboom, M. Gorris, M.J. de Maaker, J. Halfwerk, S. Lekkerkerker, M. Wielenga, M. Besselink, J. van Hooft, F. Dijk
Journal: Endoscopy (2022)

Aims In patients with main pancreatic duct (MPD) dilation, differentiation between chronic pancreatitis (CP) and main-duct or mixed-type intraductal papillary mucinous neoplasia (IPMN) can be challenging. The aim of this study was to evaluate if biomarkers in pancreatic juice, including CEA, glucose and KRAS-mutations, can aid in the differentiation between CP and IPMN with MPD involvement.
RISK OF FAILURE AND COMPLICATIONS OF ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY; COMPARISON OF ELDERLY AND YOUNG PAKISTANI PATIENTS
Authors: T. Bhatti, A. Saleem, M. Umar, T. Firoz, Z. Gul
Journal: Endoscopy (2022)

Aims Endoscopic Retrograde Cholangiopancreatography (ERCP) is an effective diagnostic and therapeutic procedure, widely performed in patients, irrespective of age. The objective of the study was to compare the risk of failure and procedural complications in young and elderly patients.
CHOLANGIOSCOPY GUIDED-RFA ABLATION OF TUMORAL INGROWTH IN A BILIARY METALLIC STENT: BURN, SPY AND WAIT
Authors: F. Pereira Correia, L. Carvalho Lourenço, D. Horta, A. Martins
Journal: Endoscopy (2022)

A 74-years-old male diagnosed with pancreatic adenocarcinoma, currently under palliative approach. Due to obstructive jaundice, a metallic biliary stent was placed. After a few months, a new metallic biliary stent was replaced due to cholangitis and evidence of tumoral ingrowth. Recently, there was new episode of obstruction of biliary stent due to tumoral ingrowth. We decided to perform cholangioscopy-guided radiofrequency ablation to reduce tumour burden and increase stent permeability. The result was good, so we did not replace a new biliary stent. After 3 months of the procedure, the patient remains stable with no evidence of biliary stent obstruction.
EVALUATION OF INTEROBSERVER AGREEMENT OF DIGITAL SINGLE-OPERATOR CHOLANGIOSCOPY FOR INDETERMINATE BILIARY STRICTURES
Authors: S.M. Milluzzo, A. Tringali, V. Perri, P. Familiari, I. Boskoski, R. Ricci, G. Costamagna
Journal: Endoscopy (2022)

Aims Visual findings during digital single-operator cholangioscopy (DSOC) still plays a major role in diagnosis of indeterminate biliary strictures (IDBS). A universally accepted classification is lacking. The Monaco Classification was recently proposed to overcome this limitation. The aim of this study was to evaluate efficacy and reproducibility of this classification.
125P De-escalation of breast cancer surgery after neoadjuvant systemic therapy in cCR/pCR patients confirmed by vacuum-assisted biopsy (VAB) and SLNB: A first report of the prospective non-randomized trial results
Authors: P. Krivorotko, S. Yerechshenko, A. Emelyanov, E. Busko, T. Tabagua, S. Novikov, A. Artemyeva, P. Krzhivitskiy, E. Zhiltsova, A. Komyahov, K. Nikolaev, L. Gigolaeva, R. Pesotsky, V. Mortada, Z. Bryantseva, V. Smirnova, V. Kushnarev, T. Semiglazova, A. Belyaev, V. Semiglazov
Journal: Annals of Oncology (2022)
108P Pathologic nodal positivity in patients with cT1-2 cN0 HER2+ breast cancer treated with upfront surgery or neoadjuvant anti-HER2-based therapy
Authors: O. Martinez Saez, C. Hernando Melia, M. Rey, N. Chic, M.T.M. Martinez, I. Cebrecos, B. Bermejo De Las Heras, X. Bargalló, O. Burgués, S. Ganau, B. Úbeda, M. Mollá, S. Vidal-Siscart, E. Sanfeliu Torres, B. Gonzalez-Farre, M. Vidal, B. Adamo, M. Munoz, A. Prat, J.M. Cejalvo Andujar
Journal: Annals of Oncology (2022)
The government wants us to learn to live with covid-19, but where is the learning?
Authors: Deepti Gurdasani, Hisham Ziauddeen
Journal: BMJ (2022)

Boris Johnson, the UK prime minister presented his government's latest strategy for living with covid-19 to the House of Commons.He stated that the high level of population immunity, the success of the vaccination programme, and the availability of antivirals meant that "restrictions" were no longer required, as the link between cases and severe disease had been "substantially weakened.
206TiP Randomized, multicenter, international phase III ARTEST study to evaluate enobosarm versus active control for the treatment of AR+ ER+ HER2- metastatic breast cancer in patients who previously received an estrogen-blocking agent and a CDK 4/6 inhibitor
Authors: A. Brufsky, H. Linden, H.S. Rugo, C. Vogel, J. O'Shaughnessy, R.H. Getzenberg, K.G. Barnette, D. Rodriguez, M.S. Steiner, E. Mayer
Journal: Annals of Oncology (2022)

Targeting the androgen receptor (AR) may be the next important endocrine therapy for advanced breast cancer. Enobosarm is an oral selective AR targeting agonist that activates the AR in breast cancer. Enobosarm has an extensive clinical experience in 25 clinical trials including in 2 phase 2 studies conducted in patients (pts) with AR+ ER+ HER2- metastatic breast cancer (MBC). An open-label, parallel design phase 2 study, was conducted in 136 women with heavily pretreated ER+ HER2- MBC that were randomized to oral daily enobosarm at a dose of 9 or 18 mg. The primary endpoint of clinical benefit rate (CBR) at 24 weeks was 32% (9 mg) and 29% (18 mg). A post-hoc AR expression subset analysis conducted in the ITT population with measurable disease at baseline revealed that the best overall response rate (ORR) was significantly higher in pts with ≥40% AR nuclei staining versus <40%, 34% and 2.7% respectively (p=0.0003) and the CBR at 24 weeks was significantly higher for ≥40% AR versus <40%, 52% and 14% respectively (p<0.0004). Overall, enobosarm was well tolerated with significant positive effects on quality-of-life measurements. The ARTEST trial is an ongoing phase 3 multicenter, international, randomized, and open-label study. Approximately, 210 pts with AR+ ER+ HER2- MBC and with AR nuclei staining ≥40% are being randomized 1:1 to either enobosarm 9 mg oral daily dose or an active comparator (physician's choice of exemestane ± everolimus or SERM). Pts must have previously received a nonsteroidal AI inhibitor, fulvestrant, and a CDK 4/6 inhibitor for MBC and had a ≥ 6 months response to hormone therapy for MBC. The primary endpoint is imaging based progression free survival as measured by RECIST 1.1. The secondary endpoints on this study include the ORR, duration of response, overall survival, change from baseline in Short Physical Performance Battery (SPPB) and change in EORTC Quality of Life Questionnaire (EORTC-QLQ). NCT04869943. Veru Inc. Veru Inc.
CLINICAL AND ENDOSCOPIC CHARACTERISTICS OF PATIENTS WITH RECURRENT ESOPHAGEAL VARICEAL HEMORRHAGE
Authors: K. Rais, O. El Mqaddem, M. Oustani, Z. Tammouch, A. Zazour, G. Kharrasse, Z. Ismaili, W. Khannoussi
Journal: Endoscopy (2022)

Aims Esophageal variceal bleeding is the most severe complication in cirrhotic patients with high frequency of rebleeding and mortality.This study aimed to identify characteristics and mortality rate of cirrhotic patients with recurrent variceal hemorrhage.
THE ROLE OF ENDOSCOPIC MANAGEMENT OF POST ORTHOTOPIC LIVER TRANSPLANT ANASTOMOTIC STRICTURES: EXPERIENCE IN A TERTIARY TRANSPLANT CENTRE
Authors: R. Stack, C. Conlon, J. Doherty, N. O'Morain, A. Mc Cormick, G. Cullen, H. Mulcahy
Journal: Endoscopy (2022)

Aims To determine the effect of endoscopic management on post orthotopic liver transplant (OLT) anastomotic strictures.
ENDOSCOPIC SUBMUCOSAL DISSECTION FOR THE TREATMENT OF A (GIANT) BALL VALVE SYNDROME
Authors: E. Dias, R. Morais, M. Marques, J. Santos-Antunes, I. Garrido, G. Macedo
Journal: Endoscopy (2022)

An 82 year-old female performed upper digestive endoscopy for diagnostic work-up of iron-deficiency anemia, which revealed a giant pedunculated gastric polyp obstructing the pylorus with extension to the second part of the duodenum. Biopsies were consistent with tubular adenoma with high-grade dysplasia. After multidisciplinary discussion, endoscopic submucosal dissection was performed and the lesion was successfully resected en-bloc without adverse events. Histopathological analysis of the specimen confirmed complete curative resection. This case highlights the expanding role of endoscopic submucosal dissection, which allowed a careful, controlled en-bloc resection of a giant gastric adenomatous polyp producing ball-valve syndrome.
CRONKHITE–CANADA SYNDROME FOLLOWING COVID-19 INFECTION
Authors: A. Chatzidakis, E. Rizos, L.-D. Lazaridis, E. Koukoulioti, A. Stamou, I.S. Papanikolaou, D. Polymeros, K. Triantafyllou
Journal: Endoscopy (2022)

A 68 year-old woman presented with chronic diarrhea, mild abdominal pain, weight loss, skin pigmentation (palms and face), brittle nails, dysgeusia and hypoalbuminemia. One month earlier she was infected with COVID-19 presenting with gastrointestinal symptoms and low grade fever. Upper GI endoscopy showed multiple large inflammatory polyps in the stomach and mucosal edema and villous blunting in the duodenum. Similarly, colonoscopy showed multiple polypoid lesions and petechiae throughout the colon, while VCE showed that most of the small intestine had similar lesions.Biopsies were supportive of Cronkhite-Canada syndrome (CCS).Thus,we may speculate that this case of CCS has been triggered by COVID-19.
All About That Ras: Novel Fusion Drives Ras Pathway Activation in Lung Cancer
Authors: Sitapriya Moorthi, Alice H. Berger
Journal: Clinical Cancer Research (2022)

Summary Lung cancers in never- and light-smokers often harbor targetable oncogenic mutations in Ras pathway genes. Here, a novel OCLN-RASGRF1 fusion is identified in an otherwise Ras wild-type lung tumor. Studying this and other RASGRF1 fusions, the authors show that these fusions lead to malignant phenotypes that can be reversed by MEK inhibition. See related article by Hunihan et al., p. 3091
RENDEZVOUS DOUBLE-BALLOON-ENTEROSCOPY ERCP AND PERCUTANEOUS TRANSHEPATIC CHOLANGIODRAINAGE (PTCD) IN THE SETTING OF ROUX-EN-Y HEPATICOJEJUNOSTOMY AFTER LIVER TRANSPLANT
Authors: K. Mönkemüller, T. Kröner, A. Alvaro Martínez-Alcalá
Journal: Endoscopy (2022)

We performed a double-balloon-enteroscopy ERCP in a patient with Roux-en-Y hepaticojejunostomy after liver transplant. The patient had undergone prior percutaneous transhepatic cholangiodrainage (PTCD) due to cholestasis and a tight hepaticojejunostomy stenosis. During DBE we reached the hepaticojejunostomy endoscopically, but due to massive looping of the enteroscope it was impossible to advance any therapeutic devices through the scope. Thus, we changed to combined DBE-ERCP with PTCD rendezvous. First, we dilated the hepaticojejunostomy percutaneously using endoscopic controlled-radial-expansion balloons, and then placed the large caliber (10 Fr) endoscopic plastic stents through-the-skin under endoscopic control, with excellent results.
The scaffold protein NEDD9 is necessary for leukemia-cell migration and disease progression in a mouse model of chronic lymphocytic leukemia
Authors: Lisa Rusyn, Sebastian Reinartz, Anastasia Nikiforov, Nelly Mikhael, Alexander vom Stein, Viktoria Kohlhas, Johannes Bloehdorn, Stephan Stilgenbauer, Philipp Lohneis, Reinhard Buettner, Sandra Robrecht, Kirsten Fischer, Christian Pallasch, Michael Hallek, Phuong-Hien Nguyen, Tamina Seeger-Nukpezah
Journal: Leukemia (2022)

Abstract The scaffold protein NEDD9 is frequently upregulated and hyperphosphorylated in cancers, and is associated with poor clinical outcome. NEDD9 promotes B-cell adhesion, migration and chemotaxis, pivotal processes for malignant development. We show that global or B-cell-specific deletion of Nedd9 in chronic lymphocytic leukemia (CLL) mouse models delayed CLL development, markedly reduced disease burden and resulted in significant survival benefit. NEDD9 was required for efficient CLL cell homing, chemotaxis, migration and adhesion. In CLL patients, peripheral NEDD9 expression was associated with adhesion and migration signatures as well as leukocyte count. Additionally, CLL lymph nodes frequently expressed high NEDD9 levels, with a subset of patients showing NEDD9 expression enriched in the CLL proliferation centers. Blocking activity of prominent NEDD9 effectors, including AURKA and HDAC6, effectively reduced CLL cell migration and chemotaxis. Collectively, our study provides evidence for a functional role of NEDD9 in CLL pathogenesis that involves intrinsic defects in adhesion, migration and homing.
APPLICABILITY AND EFFECTIVENESS OF ADVANCED ENDOSCOPIC BALLOON-TYPE IRREVERSIBLE ELECTROPORATION CATHETER ON THE ESOPHAGUS: PRECLINICAL ANIMAL PILOT STUDY
Authors: H.J. Jeon, H.-S. Choi, S.H. Kim, K.W. Lee, E.J. Bang, G. Park, J.Y. Park, J.Y. Sim, J.M. Lee, E.-S. Kim, B. Keum, Y.-T. Jeen, H.J. Chun
Journal: Endoscopy (2022)

Aims The irreversible electroporation (IRE) is a new destructive technique that removes the undesirable tissue by applying an electric field. Thus, the aim of the present study is to demonstrate the feasibility and applicability of tissue destruction in the esophagus by applying a newly designed endoscopic balloon-type IRE catheter.