tbuckley/cabot-search huggingface dataset:
Peripheral γδ T Cells Regulate Neutrophil Expansion and Recruitment in Experimental Psoriatic Arthritis
Authors: Cuong Thach Nguyen, Hiroki Furuya, Dayasagar Das, Alina I. Marusina, Alexander A. Merleev, Resmi Ravindran, Zahra Jalali, Imran H. Khan, Emanual Maverakis, Iannis E. Adamopoulos
Journal: Arthritis & Rheumatology (2022)

This study was undertaken to identify the mechanistic role of γδ T cells in the pathogenesis of experimental psoriatic arthritis (PsA).In this study, we performed interleukin-23 (IL-23) gene transfer in wild-type (WT) and T cell receptor δ-deficient (TCRδ-/- ) mice and conducted tissue phenotyping in the joint, skin, and nails to characterize the inflammatory infiltrate. We further performed detailed flow cytometry, immunofluorescence staining, RNA sequencing, T cell repertoire analysis, and in vitro T cell polarization assays to identify regulatory mechanisms of γδ T cells.We demonstrated that γδ T cells support systemic granulopoiesis, which is critical for murine PsA-like pathology. Briefly, γδ T cell ablation inhibited the expression of neutrophil chemokines CXCL1 and CXCL2 and neutrophil CD11b+Ly6G+ accumulation in the aforementioned PsA-related tissues. Although significantly reduced expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-17A was detected systemically in TCRδ-/- mice, no GM-CSF+/IL-17A+ γδ T cells were detected locally in the inflamed skin or bone marrow in WT mice. Our data showed that nonresident γδ T cells regulate the expansion of an CD11b+Ly6G+ neutrophil population and their recruitment to joint and skin tissues, where they develop hallmark pathologic features of human PsA.Our findings do not support the notion that tissue-resident γδ T cells initiate the disease but demonstrate a novel role of γδ T cells in neutrophil regulation that can be exploited therapeutically in PsA patients.
Concurrent <i>CDX2 cis</i>-deregulation and <i>UBTF::ATXN7L3</i> fusion define a novel high-risk subtype of B-cell ALL
Authors: Marie Passet, Rathana Kim, Stéphanie Gachet, François Sigaux, Julie Chaumeil, Ava Galland, Thomas Sexton, Samuel Quentin, Lucie Hernandez, Lise Larcher, Hugo Bergugnat, Tao Ye, Nezih Karasu, Aurélie Caye, Beate Heizmann, Isabelle Duluc, Patrice Chevallier, Philippe Rousselot, Françoise Huguet, Thibaut Leguay, Mathilde Hunault, Françoise Pflumio, Jean-Noël Freund, Camille Lobry, Véronique Lhéritier, Hervé Dombret, Claire Domon-Dell, Jean Soulier, Nicolas Boissel, Emmanuelle Clappier
Journal: Blood (2022)

Oncogenic alterations underlying B-cell acute lymphoblastic leukemia (B-ALL) in adults remain incompletely elucidated. To uncover novel oncogenic drivers, we performed RNA sequencing and whole-genome analyses in a large cohort of unresolved B-ALL. We identified a novel subtype characterized by a distinct gene expression signature and the unique association of 2 genomic microdeletions. The 17q21.31 microdeletion resulted in a UBTF::ATXN7L3 fusion transcript encoding a chimeric protein. The 13q12.2 deletion resulted in monoallelic ectopic expression of the homeobox transcription factor CDX2, located 138 kb in cis from the deletion. Using 4C-sequencing and CRISPR interference experiments, we elucidated the mechanism of CDX2 cis-deregulation, involving PAN3 enhancer hijacking. CDX2/UBTF ALL (n = 26) harbored a distinct pattern of additional alterations including 1q gain and CXCR4 activating mutations. Within adult patients with Ph- B-ALL enrolled in GRAALL trials, patients with CDX2/UBTF ALL (n = 17/723, 2.4%) were young (median age, 31 years) and dramatically enriched in females (male/female ratio, 0.2, P = .002). They commonly presented with a pro-B phenotype ALL and moderate blast cell infiltration. They had poor response to treatment including a higher risk of failure to first induction course (19% vs 3%, P = .017) and higher post-induction minimal residual disease (MRD) levels (MRD ≥ 10-4, 93% vs 46%, P < .001). This early resistance to treatment translated into a significantly higher cumulative incidence of relapse (75.0% vs 32.4%, P = .004) in univariate and multivariate analyses. In conclusion, we discovered a novel B-ALL entity defined by the unique combination of CDX2 cis-deregulation and UBTF::ATXN7L3 fusion, representing a high-risk disease in young adults.
CHARACTERISTICS OF HIGH-PERFORMING HOSPITALS FOR CARDIOGENIC SHOCK FOLLOWING ACUTE MYOCARDIAL INFARCTION
Authors: Dharam J. Kumbhani, Shuang Li, James A. de Lemos, Ambarish Pandey, Deepak L. Bhatt, Gregg C. Fonarow, Brahmajee K. Nallamothu, Tracy Wang, Roland Matsouaka, Anthony A. Bavry, Sandeep Das, Justin Lee Grodin, Rohan Khera, Mark H. Drazner
Journal: Journal of the American College of Cardiology (2022)
PROGRESSION FROM PAROXYSMAL TO PERSISTENT ATRIAL FIBRILLATION PRIOR TO ABLATION ASSOCIATED WITH WORSE OUTCOMES FOLLOWING PULMONARY VEIN ISOLATION
Authors: Nicolle Milstein, Matthew Saberito, Advay G. Bhatt, Mohammadali Habibi, Mark William Preminger, Tina C. Sichrovsky, Richard E. Shaw, Suneet Mittal, Dan Laurentiu Musat
Journal: Journal of the American College of Cardiology (2022)
DISTINCTIVE CHARACTERISTICS AMONG MINOCA AND TAKOTSUBO PATIENTS AND THEIR PROGNOSTIC VALUE IN A MULTICENTER PROSPECTIVE COHORT
Authors: Ioannis Leontsinis, Emmanouil K. Mantzouranis, Kyriakos Dimitriadis, Eleni Manta, Costas Thomopoulos, Theodoros Kalos, Eirini Dris, Argiris Ntalianis, Dimitrios Avramidis, Pavlos N. Stougiannos, Nikolaos Patsourakos, Dimitris Tousoulis, Konstantinos Tsioufis
Journal: Journal of the American College of Cardiology (2022)
Enhancing autophagy in Alzheimer's disease through drug repositioning
Authors: Mehdi Eshraghi, Mazaher Ahmadi, Saeid Afshar, Shahrokh Lorzadeh, Aida Adlimoghaddam, Nahid Rezvani Jalal, Ryan West, Sanaz Dastghaib, Somayeh Igder, Seyed Reza Naeimi Torshizi, Amir Mahmoodzadeh, Pooneh Mokarram, Tayyebeh Madrakian, Benedict C. Albensi, Marek J. Łos, Saeid Ghavami, Stevan Pecic
Journal: Pharmacology & Therapeutics (2022)
ELECTRICAL AND STRUCTURAL REMODELING IN HEART FAILURE AND PRESERVED EJECTION FRACTION WITH A PACEMAKER
Authors: Kazunori Omote, Frederik H. Verbrugge, Hidemi Sorimachi, Massar Omar, Dejana Popovic, Masaru Obokata, Yogesh N V Reddy, Barry Borlaug
Journal: Journal of the American College of Cardiology (2022)
HEART TRANSPLANT PATIENT OUTCOMES IN A LARGE SINGLE CENTER IN THE WEST COAST DURING THE COVID PANDEMIC
Authors: Gabriel Esmailian, Jignesh K. Patel, Michelle Maya Kittleson, Nikhil Patel, Tahli Singer-Englar, Seong Kim, Lawrence S.C. Czer, Fardad Esmailian, Jon A. Kobashigawa
Journal: Journal of the American College of Cardiology (2022)
Pausing methotrexate improves immunogenicity of COVID-19 vaccination in elderly patients with rheumatic diseases
Authors: Amanthi Nadira Arumahandi de Silva, Leonie Maria Frommert, Fredrik N Albach, Jens Klotsche, Veronika Scholz, Lara Maria Jeworowski, Tatjana Schwarz, Alexander ten Hagen, Jan Zernicke, Victor Max Corman, Christian Drosten, Gerd-Rüdiger Burmester, Robert Biesen
Journal: Annals of the Rheumatic Diseases (2022)

To study the effect of methotrexate (MTX) and its discontinuation on the humoral immune response after COVID-19 vaccination in patients with autoimmune rheumatic diseases (AIRD).In this retrospective study, neutralising SARS-CoV-2 antibodies were measured after second vaccination in 64 patients with AIRD on MTX therapy, 31 of whom temporarily paused medication without a fixed regimen. The control group consisted of 21 patients with AIRD without immunosuppressive medication.Patients on MTX showed a significantly lower mean antibody response compared with patients with AIRD without immunosuppressive therapy (71.8% vs 92.4%, p<0.001). For patients taking MTX, age correlated negatively with immune response (r=-0.49; p<0.001). All nine patients with antibody levels below the cut-off were older than 60 years. Patients who held MTX during at least one vaccination showed significantly higher mean neutralising antibody levels after second vaccination, compared with patients who continued MTX therapy during both vaccinations (83.1% vs 61.2%, p=0.001). This effect was particularly pronounced in patients older than 60 years (80.8% vs 51.9%, p=0.001). The impact of the time period after vaccination was greater than of the time before vaccination with the critical cut-off being 10 days.MTX reduces the immunogenicity of SARS-CoV-2 vaccination in an age-dependent manner. Our data further suggest that holding MTX for at least 10 days after vaccination significantly improves the antibody response in patients over 60 years of age.
LEFT VENTRICULAR VENTING AFTER VENO-ARTERIAL EXTRACORPOREAL MEMBRANE OXYGENATION IN A NON-SURGICAL TERTIARY CENTER FOLLOWING PRIMARY PERCUTANEOUS INTERVENTION IN MYOCARDIAL INFARCTION
Authors: Daniel Gayed, Danlu Liang, Joseph M. O’Brien, Joseph Vetro, John Dyett, Owen Roodenburg, Jaya Chandrasekhar
Journal: Journal of the American College of Cardiology (2022)
EJECTION FRACTION AND VENTRICULAR VOLUMES ONPOSITRON EMISSION TOMOGRAPHY: VALIDATION AGAINSTCARDIOVASCULAR MAGNETIC RESONANCE
Authors: Yushui Han, Ahmed Ibrahim Ahmed, Jean Michel Saad, Lamees El Nihum, Emily Newstrom, Yajaira Jimenez, Maan Malahfji, Mouaz AI-mallah
Journal: Journal of the American College of Cardiology (2022)
ASSOCIATION OF CARDIOVASCULAR RISK PROFILE WITH ALL-CAUSE AND CARDIOVASCULAR MORTALITY IN NON-ELDERLY US ADULTS, 2006-2014
Authors: Ryan T. Nguyen, Safi Khan, Isaac Acquah, Zulqarnain Javed, Javier Valero-Elizondo, Mohamad B. Taha, Salim S. Virani, Michael Blaha, Bashir Hanif, Ron Blankstein, Garima Sharma, Miguel Cainzos-Achirica, Khurram Nasir
Journal: Journal of the American College of Cardiology (2022)
JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency
Authors: Jui M. Dave, Raja Chakraborty, Aglaia Ntokou, Junichi Saito, Fatima Z. Saddouk, Zhonghui Feng, Ashish Misra, George Tellides, Robert K. Riemer, Zsolt Urban, Caroline Kinnear, James Ellis, Seema Mital, Robert Mecham, Kathleen A. Martin, Daniel M. Greif
Journal: Journal of Clinical Investigation (2022)

Obstructive arterial diseases, including supravalvular aortic stenosis (SVAS), atherosclerosis, and restenosis, share 2 important features: an abnormal or disrupted elastic lamellae structure and excessive smooth muscle cells (SMCs). However, the relationship between these pathological features is poorly delineated. SVAS is caused by heterozygous loss-of-function, hypomorphic, or deletion mutations in the elastin gene (ELN), and SVAS patients and elastin-mutant mice display increased arterial wall cellularity and luminal obstructions. Pharmacological treatments for SVAS are lacking, as the underlying pathobiology is inadequately defined. Herein, using human aortic vascular cells, mouse models, and aortic samples and SMCs derived from induced pluripotent stem cells of ELN-deficient patients, we demonstrated that elastin insufficiency induced epigenetic changes, upregulating the NOTCH pathway in SMCs. Specifically, reduced elastin increased levels of γ-secretase, activated NOTCH3 intracellular domain, and downstream genes. Notch3 deletion or pharmacological inhibition of γ-secretase attenuated aortic hypermuscularization and stenosis in Eln-/- mutants. Eln-/- mice expressed higher levels of NOTCH ligand JAGGED1 (JAG1) in aortic SMCs and endothelial cells (ECs). Finally, Jag1 deletion in SMCs, but not ECs, mitigated the hypermuscular and stenotic phenotype in the aorta of Eln-/- mice. Our findings reveal that NOTCH3 pathway upregulation induced pathological aortic SMC accumulation during elastin insufficiency and provide potential therapeutic targets for SVAS.
Rates of Guideline-Concordant Surgery and Adjuvant Chemotherapy Among Patients With Early-Stage Lung Cancer in the US ALCHEMIST Study (Alliance A151216)
Authors: Kenneth L. Kehl, David Zahrieh, Ping Yang, Shauna L. Hillman, Angelina D. Tan, Jacob M. Sands, Geoffrey R. Oxnard, Erin A. Gillaspie, Dennis Wigle, Shakun Malik, Thomas E. Stinchcombe, Suresh S. Ramalingam, Karen Kelly, Ramaswamy Govindan, Sumithra J. Mandrekar, Raymond U. Osarogiagbon, David Kozono
Journal: JAMA Oncology (2022)

Standard treatment for resectable non-small cell lung cancer (NSCLC) includes anatomic resection with adequate lymph node dissection and adjuvant chemotherapy for appropriate patients. Historically, many patients with early-stage NSCLC have not received such treatment, which may affect the interpretation of the results of adjuvant therapy trials.
The effect of inhaled hypertonic saline on lung structure in children aged 3–6 years with cystic fibrosis (SHIP-CT): a multicentre, randomised, double-blind, controlled trial
Authors: Harm A W M Tiddens, Yuxin Chen, Eleni-Rosalina Andrinopoulou, Stephanie D Davis, Margaret Rosenfeld, Felix Ratjen, Richard A Kronmal, Karen D Hinckley Stukovsky, Alison Dasiewicz, Stephen Michael Stick
Journal: The Lancet Respiratory Medicine (2022)
PROXIMITY OF CORONARY ARTERIES TO RVOT AS DETERMINED BY COMPUTED TOMOGRAPHY
Authors: Samer Saouma, Philippe Akhrass, Marcin Kowalski, Rina Shah, Ruben Kandov, Ravi Patel, James C. Lafferty, Valay Parikh, Mitchell D. Weinberg, Harout Yacoub
Journal: Journal of the American College of Cardiology (2022)
Measuring timely geographical access to surgical care in India: a geospatial modelling study
Authors: Tanmay Jadhav, Joao Ricardo Nickenig Vissoci, Siddhesh Zadey
Journal: The Lancet Global Health (2022)

In 2015, the Lancet Commission on Global Surgery proposed timely access to surgical care facilities as an indicator of preparedness in surgical systems. Since then, several African and South American countries have mapped the population coverage for their surgical facilities. However, these estimates are missing for India, despite its large population, geographical scope, and sociodemographic diversity. We conducted a nationwide analysis of timely access to surgical care in India and point to rural-urban disparities.We extracted a nationwide dataset of 20 802 geolocated surgical care facilities from the IndoHealMap project. We obtained accessibility motorised friction surface raster data cropped for India from the Malaria Atlas Project Explorer. We calculated the travel times from each grid cell (equivalent to 1 km2) in India to its nearest surgical facility under the optimal speed estimation by means of the Djikstra least-cost algorithm. District-level and state-level rural and urban populations were estimated through raster-based analysis via data from WorldPop, Urban-Rural Catchment Areas, and GADM version 3.6. The primary endpoint of the analysis was the proportion of population within 2 h of their nearest surgical care facility at national, state, and district levels. Wilcoxon tests adjusted for multiple comparisons (Holm-Bonferroni correction) were used to investigate rural-urban differences at a 5% significance level.The motorised travel-times distribution is highly right-skewed, depicting that a large number of areas in India were within 2 h of their nearest surgical facility. At the national level, 99·2% of the rural population had timely access to surgical care facilities, compared with 99·8% of the urban population. However, less than 80% of the rural population in the northern and northeast regions had timely access to care. The rural regions had a significantly smaller proportion of residents with timely access to surgical care compared with their and urban counterparts at the district level (n=1299, effect size=0·57; p<0·001) and state level (n=71, effect size=0·51; p<0·001) analyses.Our findings should be considered upper-bound estimates for geographical access because they assume readily available motorised transport and optimal travel speeds, which might not always be the case. These first-ever estimates can inform India's National Surgical, Obstetric, and Anesthesia Plan and which locations should be focused on for upcoming surgical facilities.No funding to declare.
INCIDENCE, PREDICTORS AND IMPACT OF POST-PROCEDURAL BLEEDING FOLLOWING IMPELLA-ASSISTED HIGH-RISK PCI
Authors: Isha Ranadive, Anoop Ninan Koshy, Gennaro Giustino, Samantha Sartori, Nitin Barman, George D. Dangas, Joseph Michael Sweeny, Annapoorna Subhash Kini, Roxana Mehran, Samin K. Sharma
Journal: Journal of the American College of Cardiology (2022)
Reliability of histologic assessment for NAFLD and development of an expanded NAFLD activity score
Authors: Rish K. Pai, Vipul Jairath, Malcolm Hogan, Guangyong Zou, Oyedele A. Adeyi, Quentin M. Anstee, Bashar A. Aqel, Cynthia Behling, Elizabeth J. Carey, Andrew D. Clouston, Kathleen Corey, Brian G. Feagan, David E. Kleiner, Christopher Ma, Stefanie C. McFarlane, Mazen Noureddin, Vlad Ratziu, Mark A. Valasek, Zobair M. Younossi, Stephen A. Harrison, Rohit Loomba
Journal: Hepatology (2022)

Abstract Background and Aims The NASH Clinical Research Network histologic scoring system, the gold‐standard NASH histology assessment for clinical trials, has demonstrated intrarater and interrater variability. An expert panel in a previous systematic Research and Development/University of California Los Angeles (RAND/UCLA) study determined that existing histologic scoring systems do not fully capture NASH disease activity and fibrosis, and standardized definitions of histologic features are needed. We evaluated the reliability of existing and alternate histologic measures and their correlations with a disease activity visual analog scale to propose optimal components for an expanded NAFLD activity score (NAS). Approach and Results Four liver pathologists who were involved in the prior RAND/UCLA study underwent standardized training and multiple discussions with the goal of improving agreement. They were blinded to clinical information and scored histologic measures twice, ≥2 weeks apart, for 40 liver biopsies representing the full spectrum of NAFLD. Index intraclass correlation coefficient (ICC) estimates demonstrated intrarater (0.80–0.85) and interrater (0.60–0.72) reliability. Hepatocyte ballooning items had similar interrater ICCs (0.68–0.79), including those extending scores from 0–2 to 0–4. Steatosis measures (interrater ICCs, 0.72–0.80) correlated poorly with disease activity. Correlations with disease activity were largest for hepatocyte ballooning and Mallory‐Denk bodies (MDBs), with both used to develop the expanded NAS (intrarater ICC, 0.90; interrater ICC, 0.80). Fibrosis measures had ICCs of 0.70–0.87. Conclusions After extensive preparation among a group of experienced pathologists, we demonstrated improved reliability of multiple existing histologic NAFLD indices and fibrosis staging systems. Hepatocyte ballooning and MDBs most strongly correlated with disease activity and were used for the expanded NAS. Further validation including evaluation of responsiveness is required.
Intensive Glycemic Treatment Reduces Diabetic Foot Ulcers
Authors: Anita Slomski
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CLINICAL PREDICTORS OF EMBOLIC BURDEN AFTER TAVR: AN ANALYSIS OF THE SAFEPASS 2 CLINICAL STUDY
Authors: Alexandra J. Lansky, Jonathon White, James T. Stewart, James W.H. Blake, David Smyth, Sanjeevan Pasupati, Rajesh Nair, Helen Parise, Cody Pietras, Mark W.I. Webster, Rika Kawakami, Renu Virmani, Jonathon Leipsic
Journal: Journal of the American College of Cardiology (2022)
REPRODUCTIVE HEALTH FEATURES ASSOCIATED WITH SPONTANEOUS CORONARY ARTERY DISSECTION: A REPORT OF THE ISCAD REGISTRY
Authors: Anna Grodzinsky, Esther S.H. Kim, Heather L. Gornik, Bryan J. Wells, Angela M. Taylor, Jennifer Lewey, Connie Ng Hess, Stanislav Henkin, Daniella Kadian-Dodov, Gretchen L. Wells, Lori Tam, Clara Vitarello, Fahad Alkhalfan, Gerald Chi, Michael Gibson, Katherine Leon, Sahar Naderi, Malissa Wood
Journal: Journal of the American College of Cardiology (2022)
Diagnostic Challenges and Uncertainties of Embolic Strokes of Undetermined Source in Young Adults
Authors: George Ntaios, Setareh Salehi Omran
Journal: JAMA Neurology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
HIGH CARDIORESPIRATORY FITNESS AND INCIDENT ATRIAL FIBRILLATION AMONG NON-ATHLETE HEALTHY ADULTS
Authors: Alon Kaplan, Alexander Fardman, Shmuel Tiosano, Yonatan Moshkovits, Shlomo Segev, Amit Segev, Robert V. Klempfner, Ehud Grossman, Elad Maor
Journal: Journal of the American College of Cardiology (2022)