tbuckley/cabot-search huggingface dataset:
Abstract 1399: Cardiac Calsequestrin Deletion Causes Premature Sarcoplasmic Reticulum Calcium Release and Catecholaminergic Polymorphic Ventricular Tachycardia in Mice
Authors: Nagesh Chopra, Tao Yang, Thinn Hlaing, Kristen Ettensohn, Izabela Holinstat, Wei Zhang, Karl Pfeifer, Dan M Roden, Bjorn C Knollmann
Journal: Circulation (2006)
Abstract 2970: Mechanism of Increased Susceptibility of Youth to Sudden Death with Chest Wall Impact (Commotio Cordis)
Authors: Christopher Madias, Nathan Dau, Barry J Maron, N.A. Mark Estes, Cynthia Bir, Link S Mark
Journal: Circulation (2007)

Background. Commotio cordis (CC), sudden cardiac death secondary to blunt, innocent-appearing chest wall blows in sports and other daily activities, is being reported with increasing frequency. Children and adolescents are most at-risk for this phenomenon. In an experimental animal model, it has been shown that ventricular fibrillation (VF) can be induced with a baseball blow to the chest wall during the vulnerable period of repolarization. We hypothesized that in this model, larger subjects would require higher impact velocities to induce VF. Methods. Under general anesthesia, 41 juvenile swine (16 to 55 kg) were placed prone in a sling and received chest wall blows at 30 to 60 mph with a lacrosse ball aimed directly over the cardiac silhouette. Impacts were timed to occur during the vulnerable period for VF (10 –30 ms prior to the T-wave peak). Animals were divided into 4 groups based on weight (16 to 25kg, 26 to 35kg, 36 to 45kg, and 46 to 55kg) and the frequency of VF was analyzed. Results. In 419 impacts, the smallest animals (16 to 25kg) were most vulnerable to VF and incidence of VF decreased incrementally as animal size increased. Impacts at 30 mph only induced VF in the smallest animals. In the largest animals (46 to 55kg), VF was only induced at impacts of 60 mph (figure ). Conclusion. Impact velocity and subject size are important variables in the generation of CC. In this animal model, smaller animals are more vulnerable to generation of VF across a wider range of impact velocities. These data might underlie the higher vulnerability to CC that has been observed in children and young adults and has implications for the prevention of CC with chest wall protectors.
Prevalence of HPV is high among Indian tribal girls and young women, study finds
Authors: C. Travasso
Journal: BMJ (2015)

Human papillomavirus (HPV) infection is more common among adolescent and young adult girls living in India’s tribal regions than their urban counterparts, a study has found. 

The study, published in PLoS One , included 2034 healthy girls and women between the ages of 9 and 25 years from eight geographically and culturally distinct tribes across Chhattisgarh, Jharkhand, and Madhya Pradesh.1 Altogether 12.9% of the participants (262 of 2034) were found to be infected with HPV, nearly two …
Abstract 3765: Differences in the Prevalence of Atrial Fibrillation and Flutter in Hispanics and Whites in a Large Community Heart Failure Population
Authors: Somjot S Brar, In-Lu A Liu, Nigel Gupta, Albert Yuh-Jer Shen
Journal: Circulation (2006)

Objective & Background: Significant racial/ethnic differences in AF prevalence have been reported between African Americans and whites. We sought to determine if the prevalence of atrial fibrillati...
Suicide within 12 months of contact with mental health services
Authors: A. Lowe, E. Heap, S. Moorey, G. Tadros, E. Salib, M D Beary, L. Appleby, J. Shaw
Journal: BMJ (1999)

Editor-Bero's editorial on commercial sponsorship for research is important 1 because commercial interests can bias the conduct and reporting of research. 2It may, however, leave the impression that pressure on research is an issue only in relation to commercial sponsorship.I used to believe that public sponsors would allow the independent conduct of research, but experiences have taught me otherwise.Recent stories in the Norwegian mass media indicate that public sponsors may also breach ethical codes for research sponsorship.Newspapers have told their readers that the ministry of education tried to influence research into the effects of an educational reform, 3 while a trade union tried to keep secret a report on privatisation of municipal services. 4 The National Council of Tobacco and Health asked a research team to change its methods for analysing the economic consequences of smoking: the methods had been agreed on before the project started, but the council later asked the team to switch to a method that would make smoking seem more "costly" to society. 5 In the end, the funding was stopped.For all three cases, the sponsors denied any unethical conduct.Industry's motive for influencing research is obvious (profit), but the motives of public sponsors may be obscure.The perceived benefits from getting the "right" results are probably related more to organisations or interest groups than to individuals.Conceivably, civil servants or other parties see themselves as agents for public interests that entitle them to influence research.In the commercial sector agents are more used to criticism for biased research and may be better aware of the ethical rules.Interestingly, some researchers say they feel less pressure when undertaking research for the pharmaceutical industry than for government.
A phase I/II study of LDE225, a smoothened (Smo) antagonist, in pediatric patients with recurrent medulloblastoma (MB) or other solid tumors.
Authors: Birgit Geoerger, Isabelle Aerts, Michela Casanova, Julia C. Chisholm, Darren R Hargrave, Sarah Leary, David M Ashley, Eric Bouffet, Tobey MacDonald, Eunju Hurh, Jyotirmoy Dey, Stacey Kalambakas, Dereck Dokyi Amakye, Mark W. Kieran
Journal: Journal of Clinical Oncology (2012)

9519 Background: Hedgehog (Hh) signaling is crucial in the development and homeostasis of many human organs and tissues. Aberrant Hh signaling is involved in tumorigenesis through promotion of cell proliferation, survival, and differentiation in wide range of human cancers, including approximately 30% of MBs. LDE225 is a potent and selective inhibitor of Smo, a key positive regulator of Hh signaling. The phase I is exploring the safety and pharmacokinetics of LDE225 in pediatric patients with advanced solid tumors that are potentially dependent on Hh signaling. Preliminary data from the ongoing phase I are presented. Methods: Dose-escalation was performed according to a Bayesian design starting at 372 mg/m 2 of continuous once daily oral LDE225. Safety and preliminary efficacy of LDE225 at the maximum tolerated dose will be assessed in pediatric and adult patients with recurrent MB in a phase II expansion part. Pharmacokinetic profiles were performed at Day 1 and 21. Tumor samples were analyzed for Hh pathway activation status using a 5-gene Hh signature assay. Results: Thirty-three patients (24 MB, 3 rhabdomyoscarcoma [RMS], 3 osteosarcoma, and 1 each of neuroblastoma, gliomatosis and oligoastrocytoma) with a median age of 13 years (range, 4–17 y) have enrolled. Dose-limiting toxicity of Grade 4 creatine phosphokinase elevation occurred in 1 RMS patient out of 7 patients treated at 372 mg/m 2 . No dose-limiting toxicity was observed at 233 and 425 mg /m 2 . LDE225 at 233 and 372 mg/m 2 was absorbed with a median T max of 2 h (range, 1–24 h). Systemic exposures were comparable with adults. Two MB patients achieved a confirmed complete response (CR) at doses of 372 and 425 mg/m 2 . Analysis of 14 available MB tumor samples using the 5-gene Hh signature assay showed that the 2 CR patients have Hh‑activated tumor. The remaining 12 tumor samples were from patients who did not achieve response and were determined to be Hh pathway non-activated. Conclusions: LDE225 is well tolerated in pediatric patients with advanced malignancies. Preliminary data show promising efficacy in medulloblastoma patients and support the use of the 5-gene Hh signature assay as a pre-selection tool in future trials.
Immediate enteral feeding after gastrointestinal resection
Authors: S M Gabe, D B A Silk
Journal: BMJ (1996)

differences are slightly larger, the disadvantages of those with low iron status are not major.In Africa the state has limited financial and other resources for maintaining health and combating disease.In the absence of prospective studies, a widespread improvement of iron status would seem to have lower priority than many other health promotion endeavours, such as water supply, immunisation of children, and 24 hour availability of staff at clinics.
Gastroscopic Real-Time<sup>13</sup>C-Urea Breath Test
Authors: H. Fruehauf, N. C. Lindenmann, K. Volkart, P. Bauerfeind, M. Fried
Journal: Endoscopy (2005)

Background and Study Aims: Biopsy-based Helicobacter urease testing (HUT) may constitute a hazard in patients with bleeding disorders, those receiving anticoagulant therapy, and those with communicable diseases. In addition, definitive test results may not immediately be available. The aim of this study was to investigate the feasibility of breath testing for H. pylori during gastroscopy (gastroscopic breath testing, GBT) in comparison with the standard HUT in a prospective, randomized, and controlled study. Patients and Methods: A total of 119 patients were randomly allocated to undergo H. pylori testing with either HUT (n = 61) or GBT (n = 58) with 75 mg of 13C-labeled urea by endoscopic instillation. Breath samples were continuously analyzed using molecular correlation spectroscopy, displaying real-time results. The procedure time and time until definitive test results were obtained (mean plus or minus standard deviation) were recorded. Results: H. pylori was detected in 10 of 49 patients (20.4 %) with HUT and in 16 of 53 (30.2 %) with GBT. Contraindications to biopsy prevented HUT in 12 of 61 patients. GBT results could not be obtained in one of the 58 patients due to respiratory disease and in four for technical reasons. Slightly less time was required to carry out HUT than GBT (121 ± 30 s vs. 164 ± 36 s; P < 0.001). Definitive test results were available within 14.0 ± 2.2 min using GBT in comparison with 19.6 ± 9.1 h for HUT (P < 0.001). GBT prolonged the time spent by the patient in the endoscopy room by only 5.6 min in comparison with HUT (45.1 ± 8.5 min vs. 39.5 ± 10.3 min; P < 0.01). Conclusions: GBT provides immediate, definitive results and allows H. pylori testing in patients in whom biopsies are contraindicated, with only minimal prolongation of the procedure time.
Gemtuzumab Ozogamicin (GO) In Children With De Novo Acute Myeloid Leukemia (AML) Improves Event-Free Survival (EFS) By Reducing Relapse Risk – Results From The Randomized Phase III Children’s Oncology Group (COG) Trial, AAML0531
Authors: Alan S. Gamis, Richard Aplenc, Todd A. Alonzo, Lillian Sung, Soheil Meshinchi, Robert B. Gerbing, Susana C. Raimondi, Betsy Hirsch, Samir Kahwash, Amy Heerema-McKenney, Laura Winter, Kathleen Glick, Ccrp Ccrp, Stella M. Davies, Patti Byron, Franklin O. Smith
Journal: Blood (2013)
The British Society of Gastroenterology
Authors: J A Gibson, G E Sladen, A M Dawson
Journal: Gut (1973)

annual meeting held at Imperial College, London, on 20-22 September.On 20 September there was a slide discussion organized by the Pathologists' Group, and a clinico- pathological conference (patient with hepato-biliary disease) of which the Chairman was Professor Sheila Sherlock.In the afternoon two symposia were held, and the first, on 'Gastrointestinal haemorrhage', was shared by the British Society for Digestive Endoscopy.The British Society of Gastroenterology scientific sessions followed on 21 and 22 September and the annual general meeting concluded the proceedings.A fuller account of the meeting appears in 'Notes and activities' on page 832, together with the names of the officers of the Society and those of the newly elected Council.
Regional Left Ventricular Myocardial Dysfunction as a Predictor of Incident Cardiovascular Events
Authors: Raymond T. Yan, David Bluemke, Antoinette Gomes, Gregory Burke, Steve Shea, Kiang Liu, Hossein Bahrami, Shantanu Sinha, Colin Wu, Veronica Fernandes, Robyn McClelland, João A.C. Lima
Journal: Journal of the American College of Cardiology (2011)
CLINICAL ASPECTS OF THE RENAL PHASE OF EPIDEMIC HEMORRHAGIC FEVER
Authors: William E. Swift
Journal: Annals of Internal Medicine (1953)

Article1 January 1953CLINICAL ASPECTS OF THE RENAL PHASE OF EPIDEMIC HEMORRHAGIC FEVERWILLIAM E. SWIFT JR.WILLIAM E. SWIFT JR.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-38-1-102 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe early acute phase of epidemic hemorrhagic fever has been discussed in earlier papers. Our experience with this disease has been limited almost completely to the later phase, following the drop of the temperature to normal. I plan to discuss briefly certain aspects of this later, or renal phase of hemorrhagic fever.The majority of almost 300 patients seen at this hospital can be classed as moderately severe. In these individuals, at about six days after onset of illness, the temperature is normal, abdominal and low back pain are still present, and there is frequently hiccoughing and vomiting. There is... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication July 25, 1952.†Present address: 147 Armory St., New Haven, Conn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRadiologic manifestations of epidemic haemorrhagic fever with renal syndromeHereditäre und endemische Nephropathien vorwiegend interstitieller LokalisationArbor-Viren (durch Arthropoden übertragbare Viren)THE FORTY-NINTH STARRENAL SEQUELÆ OF EPIDEMIC HÆMORRHAGIC FEVERDas epidemische h�morrhagische FieberThe sequelae of epidemic hemorrhagic feverAnalysis of sequential physiologic derangements in epidemic hemorrhagic fever 1 January 1953Volume 38, Issue 1Page: 102-105KeywordsHemorrhagic feversLower back painTemperatureVomiting ePublished: 1 December 2008 Issue Published: 1 January 1953 PDF downloadLoading ...
Abstract 10682: Health Disparity in Patients With Heart Failure: Ethnicity and Financial Status
Authors: Jia-rong Wu, Terry A Lennie, Debra K Moser
Journal: Circulation (2013)

BACKGROUND: Morbidity and death are higher in Blacks and in low financial status patients with heart failure (HF) compared with Whites and those with high financial status. Differences in self-care...
Abstract 18046: miR-21 is a Biomarker for Fibrosis and the Progression to Right Ventricular Systolic Failure in a Model of Pulmonary Volume and Pressure Overload
Authors: Sushma Reddy, Dong-Qing Hu, Mingming Zhao, Eddie Blay, Giovanni Fajardo, Daniel Bernstein
Journal: Circulation (2013)

Introduction: Severe pulmonary insufficiency (PI) in combination with moderate pulmonary stenosis (PS) is a common long-term complication after repair of congenital heart diseases such as tetralogy of Fallot, causing progressive right ventricular (RV) dilation and failure. We characterize the physiologic and molecular characteristics of the first murine model of combined RV volume and pressure overload (PI/PS). Methods: Physiologic data was compared between sham controls and PI/PS at 1 and 3 mos. Histopathology and gene, microRNA (miR) and protein expression were assessed in the RV free wall. Plasma miR expression was assessed in children with severe PI/moderate PS vs controls (n=4). Results: Data are presented as sham vs. PI/PS at 1 and 3 mos (*p&lt;0.05). Mice developed diastolic heart failure at 1 mo progressing to systolic heart failure by 3 mos: restrictive RV filling (E/A ratio) (0.7±0.1 vs. 2.1±0.9 and 1.9±0.4*) and elevated RV end-diastolic pressure (2.7±0.3 vs. 7.8±2, and 8.5±2 mmHg*); followed by decreased RV outflow tract shortening (44±2 vs. 39±6 and 29±6%*) and exercise capacity (32±1.1 vs. 28±1.6 and 22±1.9 min*). RV fibrosis increased over time (0 vs. 4.0±2, 3.9±0.2%* sham vs 1 and 3 mos) along with pSMAD/total SMAD expression (0.2±0.1 vs. 0.4±0.1 and 0.6±0.1*), ANP expression (25±15 and 60±27* fold at 1 and 3 mos) and tissue miR-21 expression (2.7±0.3 and 2.9±0.6 fold). However, plasma miR-21 was upregulated with diastolic heart failure and switched to being downregulated with the development of systolic heart failure (2.6±1 and -1.8 ±0.2 fold). Finally, plasma miR-21 expression from children with severe PI/moderate PS at the time of pulmonary valve replacement was downregulated compared to controls (FC -3.6±1.2). Conclusion: We describe a novel murine model of chronic RV volume and pressure overload which recapitulates many aspects of the clinical disease. Gene and protein expression changes suggest enhanced miR-21 and TGF-β signaling as a mediator of RV fibrosis. miR-21 may serve as a novel biomarker of RV fibrosis, with a decline in expression heralding the need for valve replacement. This model provides investigators with a new tool for further evaluation of a form of RV failure unique to children with repaired congenital heart disease.
Defining Functional Heterogeneity In Acute Lymphoblastic Leukemia
Authors: Stephanie M. Dobson, Esmé Waanders, Jessica McLeod, Ildiko Grandal, Olga I. Gan, Faiyaz Notta, Jessica Loo-Young-Kee, Mark D. Minden, Cynthia J. Guidos, Jayne S. Danska, Charles G. Mullighan, John E. Dick
Journal: Blood (2013)
Managing drug misuse in general practice
Authors: J. Keen
Journal: BMJ (1999)

<b>Introduction:</b><i>Mycobacterium kansasii</i> lung disease (MKLD) typically shows unilateral, upper lobe airspace opacification and cavitary disease, but clinical features with atypical disease remain unclear. The goals of the present study were to evaluate characteristics of patients diagnosed MKLD and demonstrate clinical features of patients with unusual radiological features. <b>Methods:</b> We retrospectively identified all patients from whom at least one positive <i>M. kansasii</i> culture was obtained at our hospital using data from electronic medical records from October 2010 to March 2018. We diagnosed patients based on the ATS/IDSA diagnostic criteria. We extracted patients’ demographic and clinical data and chest CT images at diagnosis. The chest CT for each patient was categorized as typical when opacification and cavitary region located only in unilateral, upper lobe. <b>Results:</b> The study comprised 62 patients (47 males, 15 females, mean age 56.7 ± 18.4 years) with MKLD. Of these, 18 patients had typical findings on chest CT (13 males, 5 females, mean age 43.1 ± 13.4) and 44 patients had atypical (34 males, 10 males, mean age 62.2 ± 17.2). Thirty one patients had pulmonary comorbidities (emphysema in 16, old tuberculosis in 6, bronchiectasis in 3, mycobacterial infection in 2, others in 6). Pulmonary comorbidities were significantly greater in patients with atypical chest CT compared with those with typical (P &lt; 0.05). <b>Conclusions:</b> We demonstrated that MKLD with underlying pulmonary comorbidities often showed atypical radiological findings.
Abstract 1845: Adult Cardiac Progenitor Cells Promote Angiogenesis and Cardioprotection through Their Secreted Soluble Vcam-1
Authors: Katsuhisa Matsuura, Atsushi Honda, Toshio Nagai, Noritoshi Fukushima, Tatsuya Shimizu, Teruo Okano, Issei Komuro, Nobuhisa Hagiwara
Journal: Circulation (2008)

Although cardiac progenitor cells have been thought to be the promising source of cell therapy, the precise mechanisms of their paracrine action have not been fully elucidated. Since we observed that the transplantation of clonal expanded Sca-1 positive cardiac progenitor cells (cSca-1 cells) derived from adult murine heart by using cell sheet technique improved cardiac function of infarcted heart compared to adipose tissue derived mesenchymal cells (ATMC), we explored the secreted factors highly expressed in cSca-1 cells and identified that soluble VCAM-1 (sVCAM-1) was much abundant in cSca-1 cells compared to ATMC by using cytokine antibody array. cSca-1 cells-derived conditioned medium (CM) significantly enhanced endothelial migration and matrigel tube formation and these effects were abolished by knock down of VCAM-1 (Fold increase: control, 1.0; CM, 2.97 ± 0.21; siVCAM-1, 1.98 ± 0.09; siControl, 2.76 ± 0.05, p&lt;0.01), suggesting that cSca-1 cells promote angiogenesis via their secreted sVCAM-1. We next examined whether sVCAM-1 conferred direct protective effects on cardiomyocytes. We exposed cardiomyocytes to 0.2 mM H 2 O 2 in the absence or presence of sVCAM-1 or CM and examined cardiomyocyte viability by MTT assay. The exposure of cardiomyocytes to H 2 O 2 significantly induced the cell injury. Interestingly when pretreated with sVCAM-1 or CM, the cell damages of cardiomyocytes by H 2 O 2 were significantly reduced. However when pretreated with anti-VLA4 antibody, a principal coreceptor of sVCAM-1, CM mediated cell protected effect was completely inhibited (Fold increase: control, 1.0; anti-VLA4, 0.89 ± 0.33; sVCAM-1, 1.69 ± 0.27; CM, 2.08 ± 0.28; CM+anti-VLA4, 1.07 ± 0.07, p&lt;0.01), suggesting that a crucial role of the VLA4 in inducing survival of cardiomyocytes by CM. sVCAM-1 and CM induced phosphorylation of FAK, Akt, Erk and p38 MAPK in neonatal rat cardiomyocytes. When pretreated with wortmannin, SB203580 and PD98059, the cardioprotective effects of sVCAM-1 and CM significantly inhibited, suggesting that sVCAM-1 might protect cardiomyocytes from oxidative stress via integrated upregulation of Akt, Erk and p38MAPK. These findings suggest cardiac progenitor cells promote angiogenesis and cardioprotection through their secreted sVCAM-1.
Bone densitometry is worth while
Authors: D. J Torgerson
Journal: BMJ (1996)

40%), moderate (19 to 29) in 28 (22%), and severe (30 and higher) in nine (7%).Half of the carers (64; 51 %) reported three or fewer physical symptoms.Quality of sleep was rated as good by 57 (46%) of carers.Depression was related (non-significantly) to age and female sex.Patient's behavioural distur- bance, assessed by the behaviour and mood dis- turbance scale,1 was the main independent correlate of carer's mood.An interaction of carers' affective state with carers' physical symp- toms and poor quality of sleep was found; in depressed carers the frequency of physical symp- toms and the quality of sleep were not influenced by patients' behavioural disturbance (table 1).In non-depressed carers the high frequency of behavioural disturbances was associated with poor perceived health-that is, more physical symptoms and poor quality of sleep.The two way interaction between depression and physical symptoms and between depression and quality of sleep was significant (P=0.022 and P=0.019 respectively on analysis of variance) even after carer's age, sex, living arrangements, number of people in the household, availability of a close confidant, number of hours of vigilance, and patient's age and score on the mini mental state examination were controlled for.Our data suggest that patients' behavioural disturbances may act as a trigger for depression in a subgroup of carers; pre-existing characteris- tics of the carers could be risk factors for the development of depression, independent of demographic characteristics, social interactions, and burden of care.
Plaque Features Associated With Increased Cerebral Infarction After Minor Stroke and TIA
Authors: Alistair C. Lindsay, Luca Biasiolli, Justin M.S. Lee, Ilias Kylintireas, Bradley J. MacIntosh, Hilary Watt, Peter Jezzard, Matthew D. Robson, Stefan Neubauer, Ashok Handa, James Kennedy, Robin P. Choudhury
Journal: JACC. Cardiovascular imaging (2012)
Abstract 16611: High Frequency QRS Analysis Improves the Diagnostic Accuracy of Exercise Stress Electrocardiography Compared to ST-Analysis for the Detection of Myocardial Ischemia
Authors: Margarita Perez, George Beller, Jamieson Bourque
Journal: Circulation (2011)

Background: The utilization of myocardial perfusion imaging (MPI) for ischemia identification leads to increased expense and radiation exposure but is driven by the limited diagnostic accuracy of e...