tbuckley/cabot-search huggingface dataset:
Sensitivity and specificity of hemodynamic criteria in the diagnosis of acute right ventricular infarction.
Authors: JLopez-Sendon, IComa-Canella, CGamallo
Journal: Circulation (1981)

To test the sensitivity and specificity of hemodynamic criteria for acute right ventricular infarction (RVI), two groups of patients with anatomically proved acute myocardial infarction and hemodynamic monitoring were studied. Group A included 22 patients acute RVI and group B, 38 with infarction confined to the left ventricle. In both groups, the closest relation between right atrial and pulmonary capillary pressures (RAP and PCP), as well as the presence of a severe noncompliant pattern (SNCP), were studied. A SNCP was defined as a y descent deeper than the x descent in RAP. RAP was equal to or higher than PCP in 10 patients from group A and in none from group B. In group B, a significant relation was found between RAP and PCP (r = 0.777, y = 0.43x + 0.18) (p less than 0.05), and the 95% confidence limits could be calculated. Above these limits, a closer relation between RAP and PCP was only found in patients with RVI. However, six patients with RVI showed an RAP/PCP relation within 95% confidence limit...
Physician-Assisted Suicide
Authors: Cavin P. Leeman
Journal: Annals of Internal Medicine (2002)

Letters6 August 2002Physician-Assisted SuicideCavin P. Leeman, MDCavin P. Leeman, MDState University of New York Downstate Medical Center; New York, NY 10011Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-3-200208060-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Most of the American College of Physicians–American Society of Internal Medicine (ACP–ASIM) position paper on physician-assisted suicide (1), which “concludes that physician-assisted suicide should be legally prohibited,” is thoughtfully written and reflects the compassion of the authors and of the members of the ACP–ASIM Ethics and Human Rights Committee. Their support for measures to improve palliative care and their acknowledgment that “some aspects of suffering [sometimes] cannot be satisfactorily controlled” are commendable. Yet their conclusion seems based more on arbitrary assertions than on thoughtfulness and compassion. The authors do not explain why the alleviation of any aspect ...References1. Snyder L, Sulmasy DP. Physician-assisted suicide. Ann Intern Med. 2001;135:209-16. [PMID: 11487490] LinkGoogle Scholar2. Ganzini L, Nelson HD, Lee MA, Kraemer DF, Schmidt TA, Delorit MA. Oregon physicians' attitudes about and experiences with end-of-life care since passage of the Oregon Death with Dignity Act. JAMA. 2001;285:2363-9. [PMID: 11343484] CrossrefMedlineGoogle Scholar3. Chin AE, Hedberg K, Higginson GK, Fleming DW. Legalized physician-assisted suicide in Oregon—the first year's experience. N Engl J Med. 1999;340:577-83. [PMID: 10021482] CrossrefMedlineGoogle Scholar4. Sullivan AD, Hedberg K, Fleming DW. Legalized physician-assisted suicide in Oregon—the second year. N Engl J Med. 2000;342:598-604. [PMID: 10684921] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Cavin P. Leeman, MDAffiliations: State University of New York Downstate Medical Center; New York, NY 10011 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPhysician-Assisted Suicide Lois Snyder and Daniel P. Sulmasy , for the Ethics and Human Rights Committee, American College of Physicians–American Society of Internal Medicine*Physician-Assisted Suicide Antoine de Torrenté Physician-Assisted Suicide Faye Girsh Physician-Assisted Suicide Lois Snyder , Daniel P. Sulmasy , and William E. Golden Metrics 6 August 2002Volume 137, Issue 3Page: 216KeywordsHealth carePalliative careSuicide ePublished: 6 August 2002 Issue Published: 6 August 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Mathematical models of myosin heterodimer formation in the rat heart during thyroid hormone alterations.
Authors: HRupp, KDietz
Journal: Circulation Research (1991)

To characterize the mechanisms involved in the formation of the myosin heavy chain (MHC) heterodimer V2 (alpha beta-MHC) and the homodimers V3 (beta beta-MHC) and V1 (alpha alpha-MHC), 82 5-week-old normotensive rats with homogeneous V1 were made hypothyroid with propylthiouracil (0.8%, drinking water), and the proportion of V2, V3, and V1 was determined by pyrophosphate gel electrophoresis in multicellular specimens of the left and right ventricles. After the switch from alpha-MHC to beta-MHC, the beta-MHC occurred initially in the form of the heterodimer. After 4 and 6 days, V2 was greater (p less than 0.05) than V3. At day 8, V2 was smaller than V3, and at day 10, V2 was not statistically different from V3. From day 12 onward, V2 was smaller than V3. After 21 days, the propylthiouracil treatment was stopped, and the remaining 34 hypothyroid rats were injected with a daily dose of thyroxine (average, 0.1 mg/kg body wt), resulting in a switch from beta-MHC to alpha-MHC. After 1 day, V2 still was greater ...
Radionuclide assessment of peripheral intravascular capacity: a technique to measure intravascular volume changes in the capacitance circulation in man.
Authors: D LRutlen, F JWackers, B LZaret
Journal: Circulation (1981)

Changes in the capacitance vasculature influence venous return and cardiac performance, so an understanding of the effects of pathophysiologic states on the human capacitance vasculature is necessary to understand integrated cardiovascular function in man. Techniques available to assess the capacitance vasculature in man, however, have limitations. We performed radionuclide imaging of the calf or forearm in 51 patients whose erythrocytes had been labeled in vivo with technetium-99m, basing our approach on the principle that counts from the radiolabeled intravascular space are proportional to blood volume. Two-minute or 15 second count acquisitions were obtained from the calf in 42 patients. Counts obtained at rest demonstrated little variation. With veno-occlusion at 15 and 30 mm Hg, counts increased 8 +/- 1% (+/- SEM) (p less than 0.001) and 28 +/- 2% (p less than 0.001), respectively. After 0.4 mg of sublingual nitroglycerin, counts increased 9 +/- 1% (p less than 0.001). With leg elevation, counts decr...
Effect of house dust mite avoidance measures in children with atopic dermatitis
Authors: R.A. Palmer, P.S. Friedmann
Journal: British Journal of Dermatology (2001)

Sir, Most studies of house dust mite (HDM) avoidance in atopic dermatitis (AD) have not measured HDM levels in the homes of subjects, a measure that greatly helps the interpretation of any changes that are detected in the severity of AD. Ricci et al.1 should be commended for doing this, and for following up subjects for a long period (1 year). The study comprised two stages. For the first 2 months, the intervention group were encouraged to employ HDM avoidance measures and the control group were not. The authors describe the study as a placebo‐controlled trial; however, there does not appear to have been a placebo. During the last 10 months, both groups used intervention measures to avoid HDM, and both groups showed reductions in the Severity Scoring of AD (SCORAD) index that were statistically significant at the 5% level. However, the mean age of subjects was only 3·9 years, and therefore spontaneous improvement would have been expected in many subjects. Therefore this part of the trial cannot fulfil the stated objective of the study, which is to verify if HDM avoidance measures can improve AD in children.
CHCHD2 and Parkinson's disease
Authors: Iris E Jansen, Jose M Bras, Suzanne Lesage, Claudia Schulte, J Raphael Gibbs, Mike A Nalls, Alexis Brice, Nicholas W Wood, Huw Morris, John A Hardy, Andrew B Singleton, Thomas Gasser, Peter Heutink, Manu Sharma
Journal: The Lancet Neurology (2015)
Impaired circadian modulation of sympathovagal activity in diabetes. A possible explanation for altered temporal onset of cardiovascular disease.
Authors: LBernardi, LRicordi, PLazzari, PSoldá, ACalciati, M RFerrari, IVandea, GFinardi, PFratino
Journal: Circulation (1992)

BACKGROUNDDiabetic subjects have a high incidence of cardiovascular accidents, with an altered circadian distribution. Abnormalities in the circadian rhythm of autonomic tone may be responsible for this altered temporal onset of cardiovascular disease.METHODS AND RESULTSTo assess circadian changes of sympathovagal balance in diabetes, we performed 24-hour power spectral analysis of RR interval fluctuations in 54 diabetic subjects (age, 44 +/- 2 years) with either normal autonomic function or mild to severe autonomic neuropathy and in 54 age-matched control subjects. The power in the low-frequency (LF, 0.03-0.15 Hz) and high-frequency (HF, 0.18-0.40 Hz) bands was considered an index of relative sympathetic and vagal activity, respectively. Diabetic subjects with autonomic abnormalities showed a reduction in LF compared with control subjects (5.95 +/- 0.12 In-msec2 versus 6.73 +/- 0.11, p < 0.001) and an even greater reduction in LF, particularly during the night and the first hours after awakening (5.11 +/...
Cholesterol-Lowering Agents
Authors: Robert S. Rosenson, Robert A. Hegele, Wolfgang Koenig
Journal: Circulation Research (2019)

Loss-of-function variants in PCSK9 (proprotein convertase subtilisin-kexin type 9) are associated with lower lifetime risk of atherosclerotic cardiovascular disease) events. Confirmation of these genetic observations in large, prospective clinical trials in participants with atherosclerotic cardiovascular disease has provided guidance on risk stratification and enhanced our knowledge on hitherto unresolved and contentious issues concerning the efficacy and safety of markedly lowering LDL-C (low-density lipoprotein cholesterol). PCSK9 has a broad repertoire of molecular effects. Furthermore, clinical trials with PCSK9 inhibitors demonstrate that reductions in atherosclerotic cardiovascular disease events are more effective in patients with recent myocardial infarction, multiple myocardial infarctions, multivessel coronary artery disease, and lower extremity arterial disease. The potent LDL-C lowering efficacy of PCSK9 inhibitors provides the opportunity for more aggressive LDL-lowering strategies in high-risk patients with atherosclerotic cardiovascular disease and supports the notion that there is no lower limit for LDL-C. Aggressive LDL-C lowering with fully human PCSK9 monoclonal antibodies has been associated by a safety profile superior to that of other classes of LDL-lowering agents. These clinical trials provide evidence that LDL lowering with PCSK9 inhibitors is an effective therapy for lowering cardiovascular events in high-risk patients with LDL-C levels ≥70 mg/dL on maximally tolerated oral therapies, including statins and ezetimibe.
Endoscopic Diagnostic Of Congenital Partial High Obstruction In Newborns: Mistakes Analysis
Authors: Y Kaminskaya, A Sautin, K Marakhouski
Journal: Endoscopy (2021)

Aims Diagnostic of congenital partial high intestinal obstruction (CPHIO) is a difficult task due to the hidden clinic and compensated condition of the newborn. Clinical signs of CPHIO may include heavy vomiting or frequent regurgitation, bloating, and weight loss. From the endoscopy point of view, the causes of CPHIO can be divided into intrinsic or extrinsic compression.
Vasodilatory action of endogenous atrial natriuretic factor in a rat model of chronic heart failure as determined by monoclonal ANF antibody.
Authors: HDrexler, CHirth, H PStasch, WLu, DNeuser, HJust
Journal: Circulation Research (1990)

Elucidation of the role of (elevated) endogenous atrial natriuretic factor (ANF) in chronic heart failure has been hampered by a lack of specific inhibitors. We used a newly developed monoclonal antibody that has been shown to specifically block both exogenously and endogenously released ANF in vivo. For assessment of the vasodilatory action of ANF in chronic heart failure, either this antibody against ANF or ascites (control serum) was injected in rats with myocardial infarction and failure and in sham animals. Ascites did not alter central hemodynamics in either the sham or infarcted group. Antibody significantly increased right atrial pressure, left ventricular end-diastolic pressure, and systemic vascular resistance (SVR) in the infarction group but did not affect these variables in the sham group. Because renal blood flow, as measured by radioactive microspheres, decreased significantly in all four groups, probably due to nonspecific renal vasoconstrictor effects of the ascites, a separate group of i...
Sex differences in clinical characteristics and risk factors for disease severity of hospitalized patients with COVID‐19
Authors: Jing‐Jing Wang, Yun‐Juan Su, Qi Wang, Ying Cao, Ai‐Bin Wang, Rui Ding, Wen Xie
Journal: MedComm (2021)

Abstract Recent studies reported sex differences in patients with coronavirus disease‐2019 (COVID‐19). We aim to analyze sex differences in clinical characteristics and risk factors for disease severity of hospitalized patients with COVID‐19 in Beijing. All adults (185 cases) diagnosed with COVID‐19 and admitted to Beijing Ditan Hospital, Capital Medical University were included in samples. The median age of all patients was 41 years. The mean body mass index (BMI) of males was relatively higher compared to females ( p &lt; 0.001). The proportion of male patients with coronary heart disease (CHD), nonalcoholic fatty liver disease (NAFLD), history of smoking and drinking was higher than females. Male patients developed more clinical symptoms, obtained more abnormal laboratory test results, while they were less aware of care‐seeking than female patients. There were no significant differences in clinical complications and outcomes between two groups. Age (odds ratio [OR]: 1.082; 95% confidence interval [CI]: 1.034–1.132; p = 0.001) and BMI (OR: 1.237; 95% CI: 1.041–1.47; p = 0.016) were considered risk factors for refractory pneumonia in multivariate regression analysis. The findings of the current study showed that SARS‐CoV‐2 was more likely to affect older males with comorbidities. Further researches into factors underlying obesity and disease severity may provide mechanistic insight into COVID‐19 development.
Antiarrhythmic activity, electrocardiographic effects and pharmacokinetics of the encainide metabolites O-desmethyl encainide and 3-methoxy-O-desmethyl encainide in man.
Authors: J TBarbey, K AThompson, D SEcht, R LWoosley, D MRoden
Journal: Circulation (1988)

Although encainide is an effective antiarrhythmic agent, plasma concentrations and pharmacologic effects are not well correlated. One explanation is the generation of active metabolites: while in most patients (extensive metabolizers; EMs) concentrations of the metabolites O-desmethyl encainide (ODE) and 3-methoxy-O-desmethyl encainide (3MODE) are higher than those of encainide, a small subset (poor metabolizers; PMs) lack the ability to extensively biotransform encainide. Considerable data from studies in vitro and animal studies, as well as indirect evidence in patients, indicate that ODE and 3MODE produce the effects seen during long-term encainide therapy in EMs. We now report the initial direct evaluation of the pharmacologic actions of these metabolites of encainide in man. Nine patients with ventricular arrhythmias, seven of the EM phenotype and two of the PM phenotype, were studied. Chronic high-frequency ventricular arrhythmias were suppressed by encainide therapy in seven of nine; monitoring arr...
Studies of the role of basophils in aspirin-exacerbated respiratory disease pathogenesis
Authors: Whitney W. Stevens, Anna G. Staudacher, Kathryn E. Hulse, Julie A. Poposki, Atsushi Kato, Roderick G. Carter, Lydia A. Suh, James E. Norton, Julia H. Huang, Anju T. Peters, Leslie C. Grammer, David B. Conley, Stephanie Shintani-Smith, Bruce K. Tan, Kevin C. Welch, Robert C. Kern, Robert P. Schleimer
Journal: Journal of Allergy and Clinical Immunology (2021)
Abstract 14104: Ten-Year Clinical Outcomes of Intermediate Coronary Lesion; Prognosis and Predictors of Major Adverse Cardiovascular Events
Authors: Jang-Ho Bae, Michel T Corban, Young Hoon Seo, Taewon Kim, Gahyeong Lee, Charanjit Rihal, Amir Lerman
Journal: Circulation (2019)

Introduction: The natural history of intermediate coronary lesions (30 to 70% angiographic stenosis) and the prognostic predictors in predicting very long-term clinical outcomes is unknown. Methods...
Effect of inhibition of endopeptidase 24.11 on responses to angiotensin II in human volunteers.
Authors: A MRichards, G AWittert, E AEspiner, T GYandle, HIkram, CFrampton
Journal: Circulation Research (1992)

The effects of endopeptidase 24.11 inhibition on angiotensin-induced changes in plasma angiotensin II, aldosterone, and atrial natriuretic factor concentrations and blood pressure were assessed in normal volunteers. Two groups, each consisting of eight normal volunteers, received stepwise infusions of angiotensin II (2, 4, and 8 ng/kg per minute) on day 5 of dose administration with 25 mg every 12 hours (group 1) or 100 mg every 12 hours (group 2) of an oral inhibitor of endopeptidase 24.11 (UK 79300, candoxatril) or placebo in balanced randomized, double-blind, placebo-controlled crossover studies. Both doses of candoxatril significantly enhanced achieved plasma angiotensin II concentrations during infusions (group 1, p < 0.001; group 2, p < 0.01; overall treatment effect for combined data, p < 0.001). This effect was most pronounced at the highest dose of angiotensin II (treatment-time interaction, p < 0.0001 for combined data) and tended to be more marked with the higher dose of candoxatril (treatment-...
Influx of neutrophils into the walls of large epicardial coronary arteries in response to ischemia/reperfusion.
Authors: R AKloner, FGiacomelli, K JAlker, S LHale, RMatthews, SBellows
Journal: Circulation (1991)

BACKGROUNDThere are several clinical situations in which large epicardial coronary arteries are deprived of blood flow, such as occurs when an obstructing thrombus or embolus lodges within a vessel or during coronary dissection. There is little information concerning the effect of flow deprivation on large epicardial coronary arteries.METHODS AND RESULTSWe studied a model in which a segment of a large epicardial coronary artery was deprived of blood flow using both proximal and distal clamps for 3 hours followed by reperfusion. On examination by light microscopy of cross sections of the arteries, 19 +/- 6 neutrophils were present in the intima of ischemic/reperfused vessels, whereas only a mean of 4 +/- 3 (SEM) were present in the intima of nonischemic vessels (p less than 0.02). On average, there were 17 +/- 9 neutrophils just under the elastic lamina in ischemic/reperfused vessels versus none in the nonischemic vessels (p less than 0.05); there were 16 +/- 10 neutrophils present within the media of isch...
Lehrbuch der Geburtshilfe.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Electrophysiologic delineation of the intraventricular His bundle in two patients with endocardial cushion type of ventricular septal defect.
Authors: MDick, D MBehrendt, K EJochim, A RCastaneda
Journal: Circulation (1981)

Two patients who had an endocardial cushion type of ventricular septal defect underwent electrophysiologic studies for detection of specialized conduction tissue during operative repair. In one patient, with an inferior leftward frontal plane QRS axis on the ECG, we recorded an intraventricular His bundle electrograms from both the anterosuperior and posteroinferior margins of the defect, suggesting dual atrioventricular conduction tracts (branching intraventricular His bundle). These anatomic and electrophysiologic findings may account for the more normally oriented QRS frontal plane axis on the surface ECG of both of these patients and support the hypothesis that the changes observed on the ECGs of patients with the various forms of endocardial cushion defect can be explained by alterations in the anatomic configuration of the specialized atrioventricular conduction tissue.
Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin
Authors: Ryan M. Burke, Ronald A. Dirkx, Pearl Quijada, Janet K. Lighthouse, Amy Mohan, Meghann O’Brien, Wojciech Wojciechowski, Collynn F. Woeller, Richard P. Phipps, Jeffrey D. Alexis, John M. Ashton, Eric M. Small
Journal: Circulation Research (2021)

Rationale: Cardiomyopathy is characterized by the deposition of extracellular matrix by activated resident cardiac fibroblasts called myofibroblasts. There are currently no therapeutic approaches to blunt the development of pathological fibrosis and ventricle chamber stiffening that ultimately leads to heart failure. Objective: We undertook a high-throughput screen to identify small molecule inhibitors of myofibroblast activation that might limit the progression of heart failure. We evaluated the therapeutic efficacy of the polyether ionophore salinomycin in patient-derived cardiac fibroblasts and preclinical mouse models of ischemic and nonischemic heart failure. Methods and Results: Here, we demonstrate that salinomycin displays potent anti-fibrotic activity in cardiac fibroblasts obtained from heart failure patients. In preclinical studies, salinomycin prevents cardiac fibrosis and functional decline in mouse models of ischemic and nonischemic heart disease. Remarkably, interventional treatment with salinomycin attenuates preestablished pathological cardiac remodeling secondary to hypertension and limits scar expansion when administered after a severe myocardial infarction. Mechanistically, salinomycin inhibits cardiac fibroblast activation by preventing p38/MAPK (mitogen activated protein kinase) and Rho signaling. Salinomycin also promotes cardiomyocyte survival and improves coronary vessel density, suggesting that cardioprotection conferred by salinomycin occurs via the integration of multiple mechanisms in multiple relevant cardiac cell types. Conclusions: These data establish salinomycin as an antifibrotic agent that targets multiple cardioprotection pathways, thereby holding promise for the treatment of heart failure patients.