tbuckley/cabot-search huggingface dataset:
Quality indicators for end-of-life breast cancer care: Testing the use of administrative databases
Authors: L. Lethbridge, E. Grunfeld, R. Dewar, G. Johnston, P. McIntyre, B. Lawson, F. Burge, S. Dent, L. Paszat, C. Earle
Journal: Journal of Clinical Oncology (2006)

6066 Background: Defining, measuring and monitoring quality of care is a facet of health services research that is growing in importance. Breast cancer offers a disease model to examine quality end-of-life (EOL) care provided to women. Administrative data have the unique potential to provide population-based measures of quality of care. The objective of this study was to assess the feasibility of using routinely-collected administrative data to measure quality EOL care for breast cancer patients. Methods: A cohort of all women in Nova Scotia who died of breast cancer between 01/01/1998 and 31/12/2002 was assembled from the Cancer Registry and Vital Statistics data. The EOL study period was defined as the last 6 months of life. A total of 864 women met the eligibility criteria. After a literature review, an expert panel identified 19 indicators that were potentially measurable through administrative data. Physician billings, hospital discharge abstracts and seniors pharmacare data, supplemented by clinical datasets, were utilized to calculate the statistics with which to represent the indicators. Results: Benchmark measures of care across the cohort show 63.4% died in a hospital, a mean continuity of care index of 0.786, and the mean number of inpatient days in the last 30 was 9.9. Indicators of aggressive care include 9.3% had chemotherapy in the last 14 days, 5.6% had more than 1 emergency room visit in the last 30 days, and 29.1% had more than 14 inpatient days in the last 30 days. Conclusions: Weaknesses of using these data include: 1) fixed variables with an administrative rather than a clinical objective; 2) lack of comprehensiveness of various datasets; and 3) the use of billings data where increasingly physicians are paid through methods other than fee-for-service. Strengths of this approach are: 1) population-based cohort; 2) comprehensiveness of cohort selection through the provincial Vital Statistics file; and 3) accessibility of data. No significant financial relationships to disclose.
Rearrangement of both immunoglobulin and T-cell receptor genes in a prolymphocytic variant of hairy cell leukemia patient resistant to interferon-alpha [published erratum appears in Blood 1989 Feb;73(2):624]
Authors: SL Giardina, HA Young, CR Faltynek, ES Jaffe, JW Clark, RG Steis, WJ Urba, BJ Mathieson, H Gralnick, J Lawrence
Journal: Blood (1988)
Verocytotoxin-producing Escherichia coli O157 outbreak in Wrexham, North Wales, July 2009
Authors: J Hart, G Smith
Journal: Eurosurveillance (2009)

An outbreak of Escherichia coli O157 involving four people in North Wales is currently being investigated. Laboratory typing shows all the isolates belong to phage type 2. All four cases reported eating different products from a fast food outlet in the area. The possibility of other common exposures is being explored.
Dual action of retinoic acid on human embryonic/fetal hematopoiesis: blockade of primitive progenitor proliferation and shift from multipotent/erythroid/monocytic to granulocytic differentiation program
Authors: A Tocci, I Parolini, M Gabbianelli, U Testa, L Luchetti, P Samoggia, B Masella, G Russo, M Valtieri, C Peschle
Journal: Blood (1996)
Addendum
Authors: W. S. Weintraub, C. R. McKay, R. N. Riner, S. G. Ellis, P. L. Frommer, D. B. Carmichael, K. E. Hammermeister, M. N. Effros, J. E. Bost, D. P. Bodycombe
Journal: Journal of the American College of Cardiology (1997)
Grand Rounds--Hammersmith Hospital: Persistent fever in pulmonary tuberculosis
Authors: M T Barakat, J Scott, J M Hughes, M Walport, J Calam, J S Friedland, P W Ind, C McKenna
Journal: BMJ (1996)

and community services.Once the organisational struc- ture and funding for treating these relatively well defined conditions has been established it may be reasonable to consider the potentially larger issue of intravenous treatment for patients with acute infections in the community.We are concerned that the pace for change is being set by a few clinical enthusiasts and by commercial organisations who have a vested interest in promoting community intravenous care.The NHS deserves a more organised strategy for purchasing treat- ment with intravenous antibiotics in the community.
Abstract 4200: Global Diastolic Strain Rate During Isovolumic Relaxation Time is a Robust Echocardiographic Parameter of Poorer Outcome in Patients With Non-ischemic Dilated Cardiomyopathy
Authors: Katsuji Inoue, Hideki Okayama, Kazuhisa Nishimura, Takayuki Nagai, Jun Suzuki, Akiyoshi Ogimoto, Tomoaki Ohtsuka, Jitsuo Higaki, Makoto Saitoh, Go Hiasa, Toyofumi Yoshii, Tadakatsu Yamada, Takumi Sumimoto, Junichi Funada
Journal: Circulation (2008)

[Background] An impairment of the global left ventricular (LV) relaxation is potential to identify patients at a risk of increased incidence of morbidity and mortality in patients with congestive heart failure (CHF). Previous reports have demonstrated that tissue Doppler and speckle tracking imaging methods serve as a quantitative assessment of LV relaxation using strain rate (SR) during isovolumic relaxation time (IVR). [Aim] This study was aimed to characterize the ability of global SR during IVR (SR-IVR) using speckle tracking imaging in predicting the outcome in patients with non-ischemic dilated cardiomyopathy (DCM). [Method] This study included 52 consecutive patients with DCM (38 male, 57+/−14 years) without overt CHF at the enrollment. We excluded patients with atrial fibrillation, complete left bundle branch block and predominant valvular heart diseases. The color-coded tissue Doppler and two-dimensional images were obtained with GE Vivid 7 in the 3 apical views for analyzing the global indexes of LV dyssynchrony (Ts-SD: standard deviation of time to peak systolic velocity in 12 LV model) and relaxation (SR-IVR: averaged longitudinal SR during IVR in 18 LV model). In addition, the levels of B-type natriuretic peptide (BNP) were also measured. Cardiac events were defined as the composite incidence of sudden cardiac death, hospitalization for worsening heart failure, and refractory CHF such as NYHA class III or IV despite of optimal medical therapy during the follow-up period. [Results] The mean values of LV ejection fraction (EF), Ts-SD, SR-IVR and BNP were 37.8%, 36.3 ms, 0.15/s and 274 pg/ml, respectively. SR-IVR was closely associated with LV end-systolic volume index (ESVI), Ts-SD and BNP (p&lt;0.01 for all). During the follow-up period (mean, 22+/−14 months), 15 patients had cardiac events and the negative value of SR-IVR was observed in 8 out of 15 patients with cardiac events. Multivariate analysis showed that among age, EF, ESVI, Ts-SD and SR-IVR, SR-IVR was the only independent echocardiographic predictor of cardiac events in this study population (β= 0.486, p&lt; 0.01). [Conclusion] The reduction and negative value of global SR-IVR was shown to be a robust echocardiographic parameter for poorer outcomes in patients with DCM.
EUVAC-Net - the surveillance network for vaccine-preventable diseases is now hosted by ECDC
Authors: T Derrough, A Navarro Torné
Journal: Eurosurveillance (2011)

Preview this article: EUVAC-Net - the surveillance network for vaccine-preventable diseases is now hosted by ECDC, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/16/37/art19964-en-1.gif
Abstract 2501: Plasma Heart-type Fatty-acid Binding Protein Associates With Outcomes in Out-of-hospital Cardiac Arrest
Authors: Min-Shan Tsai, Chien-Hua Huang, Chiung-Yuan Hsu, Wei-Tien Chang, Wen-Jone Chen
Journal: Circulation (2009)

Background: Plasma heart-type fatty acid binding protein (H-FABP), released from injured myocardium into circulation, is associated with survival in patients with heart failure and myocardial damag...
Book: Selected Writings: Anna Freud
Authors: P. Caviston
Journal: BMJ (1999)

Penguin Books, £8.99, pp 304 ISBN 0 14 026814 6 Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> The youngest of Freud's six children, Anna's life was inextricably linked with psychoanalysis from the start. By the age of 5,her dreams were being used by papa Freud to illustrate his work. As a teenager, she immersed herself in his writing and attended his lecture course on psychoanalysis. She was 23years old when she entered analysis with her own father. Her first publication came a few years later with the title Beating Fantasies and Daydreams . This explored the theme of sexualised “phantasies” as substitutes for incestuous wishes between … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
Finally, a successful adjuvant therapy for high-risk melanoma.
Authors: C M Balch, A C Buzaid
Journal: Journal of Clinical Oncology (1996)

AbstractJanuary 01, 1996 Share on Finally, a successful adjuvant therapy for high-risk melanoma.Authors: C M Balch and A C BuzaidAuthors Info & AffiliationsPublication: Journal of Clinical OncologyVolume 14, Number 1https://doi.org/10.1200/JCO.1996.14.1.1 Get Access
Incidence and remission of lower urinary tract symptoms
Authors: S. Jackson
Journal: BMJ (2000)

Impact of NHS Direct on demand for immediate care Target communities show poor awareness of NHS DirectEditor-Munro et al found that NHS Direct had no discernible effect on the use of emergency ambulances or accident and emergency departments in the first year of operation, leading to a suggestion that this service may not prove cost effective. 1 The study is limited by an assumption that the population studied had complete awareness of the service.Six months after the introduction of East Midlands NHS Direct we had anecdotal evidence to suggest that many patients attending our accident and emergency department were unaware of the telephone advisory service.Consequently we undertook a survey of 300 consecutive ambulatory patients (or their parents) who referred themselves to the accident and emergency department and had not contacted NHS Direct.We wanted to find out whether they were aware of the service.Altogether 266 (89%) questionnaires were completed, with 166 (62%) patients claiming to have had no previous awareness of NHS Direct.Furthermore, of the 100 patients who were aware of the service, only 36 were aware of the telephone charge while 51 thought that calls were taken by doctors.Only eight "aware" patients, however, said that they would distrust advice given by a nurse, a finding that supports a study by O'Cathain et al. 2 The survey also determined which sections of the community were unaware of NHS Direct.Patients aged over 65 (all 9), patients from ethnic minorities (41/59; 69%), patients from predominantly less affluent postcodes (101/129; 78%), and young men (20/28; 71%) were overrepresented.The survey also found that 240 (90%) patients claimed to have access to a telephone and that 56 (21%) might have been redirected away from our department by NHS Direct.In the light of these findings we would say that NHS Direct has failed to market its existence to those members of the community who frequently access urgent health care.The results of NHS Direct impact studies have consequently been confounded by this oversight.Whether a proper national publicity campaign can improve the impact of this beleaguered service remains to be seen.
Membrane Phospholipid Asymmetry in Human Thalassemia
Authors: Frans A. Kuypers, Jie Yuan, Rachel A. Lewis, L. Michael Snyder, Charles R. Kiefer, Ahnond Bunyaratvej, Suthat Fucharoen, Lisa Ma, Lori Styles, Kitty de Jong, Stanley L. Schrier
Journal: Blood (1998)
Electrochemical Detection of Single A-G Mismatch Using Biosensing Surface Based on Gold Nanoparticles
Authors: Ren-Yun Zhang, Xue-Mei Wang, Sheng-Jin Gong, Nong-Yue He
Journal: Genomics Proteomics & Bioinformatics (2005)

Abstract The study of small drug molecules interacting with nucleic acids is an area of intense research that has particular relevance in our understanding of relative mechanism in chemotherapeutic applications and the association between genetics (including sequence variation) and drug response. In this contribution, we demonstrate how the sequence-specific binding of an anticancer drug Dacarbazine (DTIC) to single base (A-G) mismatch could be sensitively detected by combining electrochemical detection with biosensing surface based on gold nanoparticles.
Outcome Of Escherichia Coli (E.coli) Blood Stream Infections (BSI) In Haematology-Oncology Patients- Hematopoetic Stem Cell Transplantation (HSCT) Is Not Associated With Increased Mortality
Authors: Zena Salih, Felicity Fergusson, Andrew Stevens, Katalina Balassa, Theingi Yin, Kirsty Dodgson, Kaczmarsky Ed, Malcolm Guiver, Ken Mutton, Mike Dennis, Jim Cavet, Tim Sommervaile, Jo Tomlins, John Murray, Adrian Bloor, Samar Kulkarni
Journal: Blood (2013)
Problem based learning at medical school
Authors: R. Farrow
Journal: BMJ (1995)

substantially increase the cost per admission.In addition, we are responsible for transporting and escorting our patients for court appearances; this cost would otherwise be met by the Home Office.Should local purchasers be responsible for these costs in future?We are convinced that the proper place for mentally disordered prisoners requiring hospital treannent is hospital.We have shown that the problems described by Needham-Bennett and Cumming are not insoluble; the solution is not legislative but financial.The delays inherent in the resolution of serious cases inflate our costs.We have expressed our concerns to the Home Office but have received only an acknowledgement.In the absence of any acceptance of joint responsibility by the Department of Health and the Home Office for funding services for mentally disordered remand prisoners, we believe that the current situation is a disaster that is already happening.
Abstract 11545: Mechanism of Chronic Phosphodiesterase Type 5 Inhibition-Caused Regression of Heart Failure: Beneficial Effects of Left Ventricular and Myocyte Function, [Ca2+]i Regulation and Beta-Adrenergic Modulation
Authors: Tiankai Li, Qun Shao, Heng-Jie Cheng, Michael F Callahan, Wei-Min Li, Che Ping Cheng
Journal: Circulation (2013)

Background: Phosphodiesterase type 5 (PDE5) inhibition (I) has been shown to exert profound beneficial effects in heart failure (HF). However, the mechanisms are not completely understood. It remai...
Real-Life Observations of Clinical Outcomes With Rhythm- and Rate-Control Therapies for Atrial Fibrillation
Authors: A. John Camm, Günter Breithardt, Harry Crijns, Paul Dorian, Peter Kowey, Jean-Yves Le Heuzey, Ihsen Merioua, Laurence Pedrazzini, Eric N. Prystowsky, Peter J. Schwartz, Christian Torp-Pedersen, William Weintraub
Journal: Journal of the American College of Cardiology (2011)
Alexithymia and Handedness
Authors: Paul Rodenhauser, H.J. Khamis, Alice Faryna
Journal: Psychotherapy and Psychosomatics (1986)

Exploration of the connection between alexithymia and handedness has not been addressed in the literature. Although trends which have been reported between alexithymia and characteristics of individuals may vary with the methods of assessment and types of population, the possible relationships between alexithymia and males and between left-handedness and males raise questions about the relationship between alexithymia and handedness. This pilot study (n = 100) indicates a higher incidence of alexithymia in individuals who are not right-handed. The possible influence of left hemisphere development on the occurrence of alexithymia is discussed.
Case history breached confidentiality
Authors: R. Kerwin
Journal: BMJ (1995)

technique, and outcome of peripheral thrombolysis for the past two years.2This is a continual process to provide a system for the national audit of peripheral arterial thrombolysis, and so far over 450 events of thrombolysis have been recorded.In these, only 13% of infusions were given with a pulse spray technique, in a median time of six hours (range 1-78 hours).Pulse spray lysis is certainly faster than conventional low dose techniques, but it requires expensive catheters and infusion systems.Other methods, such as high dose bolus thrombolysis and six hourly dose infusions, have also been reported to reduce infusion times without expensive equipment.34Personal communications with the manu- facturers of pulse spray infusion catheters also suggest that relatively few hospitals in Britain use the pulse spray technique.Little information is available on many of the techniques for peripheral thrombolysis, and low dose infusions remain the gold standard for many hospitals in Britain.
发热-贫血-血小板降低-肺内多发结节
Authors: 李娅, 王玉, 曾学军, 范洪伟
Journal: BMJ (2010)

患者男,39岁,因＂间断发热、贫血、血小板降低3年,发现肺部多发结节20 d＂于2009年5月31日入我院. 2006年3月患者偶查血常规：血红蛋白（Hb）97g/L、血小板（PLT）51×109/L.之后出现发热,于外院曾诊断＂结缔组织病＂,予激素治疗（具体不详）,体温降至正常.
Scent trails
Authors: Geoff Watts
Journal: BMJ (2007)

Tell the world that you are blind or deaf or have no sense of touch and you can count on a measure of sympathy. But say that you have lost your sense of smell and the response will be, likely as not, indifference. We humans are not animals, are we? Of all our senses, smell is the least important.

Maybe so—but that is small consolation to people with the problem. Still more dispiriting for them is the lack of medical interest in disorders of smell, whether in treatment or research. Of the handful of UK clinicians with a special interest in the topic, two of the most active took it up more or less by chance and have to combine it with other work.
Thyroidectomy and parathyroidectomy: a guide for patients
Authors: Aeb Giddings
Journal: Journal of the Royal Society of Medicine (1998)

The thyroid gland lies in the neck and makes thyroxine which is a very important hormone. If too little thyroxine is present, children's growth and development are retarded and adults become slow, depressed, fat and constipated (myxoedema). If too much thyroxine is secreted, patients become over-active, thin, ravenously hungry and find difficulty in sleeping (thyrotoxicosis). Elderly patients with thyrotoxicosis may develop heart problems, causing palpitations. Small thyroids may be under-active, so may be lumpy or large glands. Therefore there are two common problems in diagnosis:
Real-Time 3-Dimensional Echocardiographic Assessment of Left Ventricular Dyssynchrony
Authors: Carolin Sonne, Lissa Sugeng, Masaaki Takeuchi, Lynn Weinert, Roderick Childers, Nozomi Watanabe, Kiyoshi Yoshida, Victor Mor-Avi, Roberto M. Lang
Journal: JACC. Cardiovascular imaging (2009)
Abstract 5609: In-Stent Restenosis - Benign or Dangerous? Clinical Presentation of Coronary Restenosis in Sweden
Authors: Elmir Omerovic, Truls Ramunddal, Lars Grip, Jan Boren, Goran Matejka, Per Albertsson
Journal: Circulation (2008)

Background Restenosis after percutaneous coronary intervention (PCI) was earlier thought to be a benign event clinically manifested as stable exertional angina. The aim of this prospective multicenter registry study was to investigate the incidence of acute coronary syndrome in patients with restenosis in Sweden. Methods Using data from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR), we analyzed all registered cases of PCI for restenosis (in-stent, after balloon angioplasty) from 1995 to 2005 in Sweden. Both multivessel and single vessel interventions were included. Restenosis presentations were classified as: stable angina; unstable angina/non-STEMI; STEMI; and other reasons. As routine angiographic screening was not performed, restenosis episodes were defined clinically based on symptoms. Results We identified 6642 cases of restenosis in 2978 patients (4790 in men, 1852 in women). Restenosis presented in 39.7% of cases as stable angina, in 46.0% as unstable angina/non-STEMI, in 11.5% as STEMI and in 2.8% as other reasons. Cardiogenic shock was reported in 48 patients. Women had a higher incidence of unstable angina/non-STEMI compared with men (52.3% v. 43.6%) but a lower incidence of STEMI (9.6% v. 12.2%). The frequency of STEMI was lower with restenosis after balloon angioplasty v. in-stent restenosis (6.9% v. 13.8%), and after drug-eluting stents v. bare metal stents (7.9% v. 18.5%). Mortality rate was 1.7% at 30 days, 3.2% at 6 months and 4.6% at one year in patients with restenosis. These covariates were independent predictors of acute coronary syndrome: gender, age, vessel diameter, smoking, stent type, number of stents, treated vessel, previous stroke and previous infarction. Conclusion The majority of patients with coronary restenosis present either with acute MI or unstable angina requiring hospitalization and new interventions. Women may have a higher risk of developing acute coronary syndrome due to restenosis. Prevention of restenosis may be an important target for improvement of “hard” clinical outcomes in patients undergoing coronary revascularization.
Abstract 254: Comparison of Cold Crystalloid and Colloid Infusions for Induction of Therapeutic Hypothermia in a Porcine Model of Cardiac Arrest
Authors: Anatolij Truhlar, Roman Skulec, Zdenek Turek, Renata Parizkova, Vladimir Cerny
Journal: Circulation (2011)

Introduction: Cold crystalloids have been used for induction of therapeutic hypothermia after cardiac arrest but so far the effectiveness of cold colloids has not been evaluated. This prospective study investigates the cooling effect of rapid intravenous infusion of cold crystalloid compared to colloid in a porcine model of ventricular fibrillation (VF). Methods: VF was electrically induced in twenty-two anesthetized domestic pigs (33 ± 2 kg). Defibrillation was attempted after 15 min CPR using the AutoPulse (Zoll Medical, USA) and artificial ventilation. After spontaneous circulation was restored, the animals were randomized to receive either 1500 mL of 1°C cold Voluven [6% hydroxyethyl starch 130/0.4 in 0.9% NaCl] within 25 min using a Zoll Power Infuser (group A; n = 9), or 1500 mL of 1°C cold normal saline (group B; n = 9), or no infusion (group C; n = 4). The animals were observed for 90 min following infusion. Cerebral, rectal, intramuscular, pulmonary artery, and subcutaneous fat body temperatures (BT) were continuously recorded using GES 130 temperature probes and GMH 3250 digital thermometers with logger function (Greisinger Electronic, Germany). Data were analyzed with JMP 3.2 software (SAS Institute, USA) and are expressed as a mean ± SD. P &lt; 0.05 was considered statistically significant. Results: 45.6 ± 2.7 mL·kg -1 of cold colloid was infused in group A, and 46.8 ± 3.1 mL·kg -1 of crystalloid in group B. The animals treated with cold fluids achieved a significant decrease of BT in all measurement sites while there was a spontaneous increase in group C. At the time of finishing infusion there was a greater decrease in cerebral and pulmonary artery temperatures in group B compared to group A (-1.7 ± 0.4 vs. -1.1 ± 0.3 °C, P &lt; 0.05, and -2.1 ± 0.3 vs. -1.6 ± 0.2 °C, P &lt; 0.05 respectively). Area under the curve (AUC) analysis of the decrease in intra-cerebral BT revealed a more vigorous cooling effect in group B compared to A (-91 ± 30 vs. -62 ± 32 °C·min, P = 0.06). There was also a higher calculated amount of absorbed heat for crystalloids compared to colloids (33.9 ± 5.7 vs. 26.6 ± 3.4 cal, P &lt; 0.05). Conclusion: Cold crystalloid infusions resulted in a more intense cooling effect than colloid infusions of the same temperature and infusion rate in this porcine model of cardiac arrest.