tbuckley/cabot-search huggingface dataset:
NBCn1 Increases NH4 + Reabsorption Across Thick Ascending Limbs, the Capacity for Urinary NH4 + Excretion, and Early Recovery from Metabolic Acidosis
Authors: Jeppe S. M. Olsen, Samuel Svendsen, Peder Berg, Vibeke S. Dam, Mads V. Sorensen, Vladimir V. Matchkov, Jens Leipziger, Ebbe Boedtkjer
Journal: Journal of the American Society of Nephrology (2021)

The electroneutral Na+/HCO3- cotransporter NBCn1 (Slc4a7) is expressed in basolateral membranes of renal medullary thick ascending limbs (mTALs). However, direct evidence that NBCn1 contributes to acid-base handling in mTALs, urinary net acid excretion, and systemic acid-base homeostasis has been lacking.Metabolic acidosis was induced in wild-type and NBCn1 knockout mice. Fluorescence-based intracellular pH recordings were performed and NH4+ transport measured in isolated perfused mTALs. Quantitative RT-PCR and immunoblotting were used to evaluate NBCn1 expression. Tissue [NH4+] was measured in renal biopsies, NH4+ excretion and titratable acid quantified in spot urine, and arterial blood gasses evaluated in normoventilated mice.Basolateral Na+/HCO3- cotransport activity was similar in isolated perfused mTALs from wild-type and NBCn1 knockout mice under control conditions. During metabolic acidosis, basolateral Na+/HCO3- cotransport activity increased four-fold in mTALs from wild-type mice, but remained unchanged in mTALs from NBCn1 knockout mice. Correspondingly, NBCn1 protein expression in wild-type mice increased ten-fold in the inner stripe of renal outer medulla during metabolic acidosis. During systemic acid loading, knockout of NBCn1 inhibited the net NH4+ reabsorption across mTALs by approximately 60%, abolished the renal corticomedullary NH4+ gradient, reduced the capacity for urinary NH4+ excretion by approximately 50%, and delayed recovery of arterial blood pH and standard [HCO3-] from their initial decline.During metabolic acidosis, NBCn1 is required for the upregulated basolateral HCO3- uptake and transepithelial NH4+ reabsorption in mTALs, renal medullary NH4+ accumulation, urinary NH4+ excretion, and early recovery of arterial blood pH and standard [HCO3-]. These findings support that NBCn1 facilitates urinary net acid excretion by neutralizing intracellular H+ released during NH4+ reabsorption across mTALs.
MO01.45 Health-Related Quality of Life (HRQoL) in Patients with NSCLC Harboring MET Exon 14 Skipping (METex14) Treated with Tepotinib
Authors: M. Garassino, X. Le, D. Kowalski, M. Migliorino, H. Senellert, J. Pradera, R. Walling, T. Kato, M. Thomas, E. Smit, M. Gottfried, C. Britschgi, A. Johne, J. Scheele, R. Bruns, H. Vioix, B. Pfeiffer, P. Paik
Journal: Journal of Thoracic Oncology (2021)
Correspondence on ‘What comes after the lockdown? Clustering of ANCA-associated vasculitis: single-centre observation of a spatiotemporal pattern’
Authors: Samy Hakroush, Björn Tampe
Journal: Annals of the Rheumatic Diseases (2021)

We read with great interest the recent article by Gauckler et al reporting 15 patients diagnosed with antineutrophil cytoplasm antibodies-associated vasculitides (AAV) during the COVID-19 pandemic between February and August 2020. During this period, the authors report an incidence shift with a COVID-19 gap of no diagnosed AAV cases during the lockdown period in March and April 2020, followed by a postlockdown phase in the subsequent 4 months and an increased incidence rate.1 Diagnosis of AAV can be delayed during the COVID-19 pandemic because non-urgent tests and visits might have been postponed due to closure of medical services during the lockdown. We here report a single-centre observation in 28 patients diagnosed AAV with kidney involvement requiring renal biopsy in 2019 …
Abstract 11832: Does Severity of Sleep Apnea Affect Compliance With CPAP Therapy?
Authors: David Golombeck, Jacqueline Pimienta, Nicolle S Milstein, Advay G Bhatt, Tina C Sichrovsky, Mark Preminger, David Rosen, Jeannean Hernandez, Carissa Pistilli, Suneet Mittal, Dan L Musat
Journal: Circulation (2019)

Background: Patients (pts) with atrial fibrillation (AF) commonly suffer from obstructive sleep apnea (OSA). The Apnea + Hypopnea Index (AHI) is used to diagnose the severity of OSA. Patients with ...
Synergistic Antibacterial and Anti‐Inflammatory Effects of a Drug‐Loaded Self‐Standing Porphyrin‐COF Membrane for Efficient Skin Wound Healing
Authors: Luo‐Gang Ding, Song Wang, Bing‐Jian Yao, Fei Li, Yan‐An Li, Guo‐Yan Zhao, Yu‐Bin Dong
Journal: Advanced Healthcare Materials (2021)

Abstract Chronic wound infections resulting from severe bacterial invasion have become a major medical threat worldwide. Herein, we report a large‐area, homogeneous, and self‐standing porphyrin‐covalent organic framework (COF)‐based membrane with encapsulated ibuprofen (IBU) via an in situ interfacial polymerization and impregnation approach. The obtained IBU@DhaTph‐membrane exhibits highly effective antibacterial and anti‐inflammatory effects via synergistic light‐induced singlet oxygen ( 1 O 2 ) generation and controllable IBU release, which is well supported by in vitro experiments. In addition, the IBU@DhaTph‐membrane‐based biocompatible “band‐aid” type dressing is fabricated, and its excellent anti‐infection and tissue remodeling activities are fully evidenced by in vivo chronic wound‐healing experiments. This study may inspire and promote the fabrication of many more new types of COF‐based multifunctional biomaterials for various skin injuries in clinical medicine.
Mitigating ethnic disparities in covid-19 and beyond
Authors: Mohammad S Razai, Hadyn K N Kankam, Azeem Majeed, Aneez Esmail, David R Williams
Journal: BMJ (2021)

The disproportionate effect of covid-19 on ethnic minorities in some high income countries throws into sharp relief the effects of racism on health.On almost all health measures, ethnic minority groups, especially black and South Asian people, have the worst outcomes. 1 -6 The covid-19 pandemic is just another example. 7This is a moral issue that has outraged civilised societies.As Alexandre Dumas wrote: "Moral wounds have this peculiarity-they may be hidden, but they never close; always painful, always ready to bleed when touched, they remain fresh and open in the heart."The effects of racism and social determinants of health are intertwined.Racism both shapes social determinants of health and has its own effect on the health of ethnic minorities.To understand race and health, we must understand the role of ethnicity and racism within modern societies.Everyday acts of interpersonal discrimination, implicit biases, cultural and structural racism will over time lead to worse health outcomes, including higher rates of chronic diseases and lower life expectancy.
NCCN Guidelines Insights: Acute Myeloid Leukemia, Version 2.2021
Authors: Daniel A. Pollyea, Dale Bixby, Alexander Perl, Vijaya Raj Bhatt, Jessica K. Altman, Frederick R. Appelbaum, Marcos de Lima, Amir T. Fathi, James M. Foran, Ivana Gojo, Aric C. Hall, Meagan Jacoby, Jeffrey Lancet, Gabriel Mannis, Guido Marcucci, Michael G. Martin, Alice Mims, Jadee Neff, Reza Nejati, Rebecca Olin, Mary-Elizabeth Percival, Thomas Prebet, Amanda Przespolewski, Dinesh Rao, Farhad Ravandi-Kashani, Paul J. Shami, Richard M. Stone, Stephen A. Strickland, Kendra Sweet, Pankit Vachhani, Matthew Wieduwilt, Kristina M. Gregory, Ndiya Ogba, Martin S. Tallman
Journal: Journal of the National Comprehensive Cancer Network (2021)

The NCCN Guidelines for Acute Myeloid Leukemia (AML) provide recommendations for the diagnosis and treatment of adults with AML based on clinical trials that have led to significant improvements in treatment, or have yielded new information regarding factors with prognostic importance, and are intended to aid physicians with clinical decision-making. These NCCN Guidelines Insights focus on recent select updates to the NCCN Guidelines, including familial genetic alterations in AML, postinduction or postremission treatment strategies in low-risk acute promyelocytic leukemia or favorable-risk AML, principles surrounding the use of venetoclax-based therapies, and considerations for patients who prefer not to receive blood transfusions during treatment.
Barriers and facilitators to implementing perinatal mental health care in health and social care settings: a systematic review
Authors: Rebecca Webb, Nazihah Uddin, Elizabeth Ford, Abigail Easter, Judy Shakespeare, Nia Roberts, Fiona Alderdice, Rose Coates, Sally Hogg, Helen Cheyne, Susan Ayers, Elaine Clark, Evelyn Frame, Simon Gilbody, Agnes Hann, Sarah McMullen, Camilla Rosan, Debra Salmon, Andrea Sinesi, Claire Thompson, Louise R Williams
Journal: The Lancet Psychiatry (2021)
The Sporobiota of the Human Gut
Authors: Muireann Egan, Eugene Dempsey, C. Anthony Ryan, R. Paul Ross, Catherine Stanton
Journal: Gut Microbes (2021)

The human gut microbiome is a diverse and complex ecosystem that plays a critical role in health and disease. The composition of the gut microbiome has been well studied across all stages of life. In recent years, studies have investigated the production of endospores by specific members of the gut microbiome. An endospore is a tough, dormant structure formed by members of the Firmicutes phylum, which allows for greater resistance to otherwise inhospitable conditions. This innate resistance has consequences for human health and disease, as well as in biotechnology. In particular, the formation of endospores is strongly linked to antibiotic resistance and the spread of antibiotic resistance genes, also known as the resistome. The term sporobiota has been used to define the spore-forming cohort of a microbial community. In this review, we present an overview of the current knowledge of the sporobiota in the human gut. We discuss the development of the sporobiota in the infant gut and the perinatal factors that may have an effect on vertical transmission from mother to infant. Finally, we examine the sporobiota of critically important food sources for the developing infant, breast milk and powdered infant formula.
Efficacy and Safety of Lenvatinib Therapy for Unresectable Hepatocellular Carcinoma in a Real-World Practice in Korea
Authors: Myung Ji Goh, Joo Hyun Oh, Yewan Park, Jihye Kim, Wonseok Kang, Dong Hyun Sinn, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik
Journal: Liver Cancer (2021)

Lenvatinib has been recently approved as a first-line treatment option for patients with unresectable hepatocellular carcinoma (HCC) in Korea. We aimed to study the efficacy and safety of lenvatinib therapy in a real-world practice and to find prognostic factors related to survival and disease progression.A hospital-based retrospective study was conducted on 111 consecutive patients who had unresectable HCC and were treated with lenvatinib at Samsung Medical Center from October 2018 to March 2020. Efficacy was determined using the modified Response Evaluation Criteria in Solid Tumors (mRECIST) criteria in 111 patients who completed 1st tumor assessment. Safety was evaluated in 116 HCC patients including 5 patients who discontinued lenvatinib due to adverse events (AEs) before 1st tumor assessment using Common Terminology Criteria for AEs version 5.0.A total of 111 patients with a median age of 59 years were analyzed during a median follow-up duration of 6.2 (4.4-9.0) months. The Kaplan-Meier estimate of overall survival was 10.5 months, and the median progression-free survival was 6.2 months. Based on mRECIST criteria, the objective response rate was 18.9% and disease control rate was 75.7%. AEs developed in 86/116 (74.1%) patients, and grade ≥3 AEs developed in 16/116 (13.8%) patients. Diarrhea, hand-foot skin rash, abdominal pain, hypertension, and anorexia were identified as the AEs with the highest frequencies of any grade. REFLECT eligibility criteria including tumor extent ≥50% liver occupation or inadequate bone marrow function and occurrence of anorexia were prognostic factors for survival, and occurrence of diarrhea was a favorable factor for disease progression.Lenvatinib therapy showed a favorable efficacy and safety in a real-world practice. The REFLECT eligibility criteria and specific AEs could be one of the prognostic markers.
Erratum : Curriculum for optical diagnosis training in Europe: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement (Endoscopy (2020) 52 (899-923) DOI: 10.1055/a-1231-5123)
Authors: Evelien Dekker, Britt B. S. L. Houwen, Ignasi Puig, Marco Bustamante-Balén, Emmanuel Coron, Daniela E. Dobru, Roman Kuvaev, Helmut Neumann, Gavin Johnson, Pedro Pimentel-Nunes, David S. Sanders, Mario Dinis-Ribeiro, Marianna Arvanitakis, Thierry Ponchon, James E. East, Raf Bisschops
Journal: Endoscopy (2020)

In the above-mentioned article, one sentence on page 912 (Optical diagnosis training for early gastric cancer, Part B) has been corrected. Correct is: The curriculum committee suggests, based on personal experience, that assessment of at least 20 gastric lesions prospectively in patients at high risk of gastric dysplasia/EGC is needed before competence should be assessed. This was corrected in the online version on September 23, 2020.
Immobilized thrombin on X-ray radiopaque polyvinyl alcohol/chitosan embolic microspheres for precise localization and topical blood coagulation
Authors: Xiaohong Li, Xiongfa Ji, Kun Chen, Muhammad Wajid Ullah, Basen Li, Jiameng Cao, Lin Xiao, Jun Xiao, Guang Yang
Journal: Bioactive Materials (2021)

Trans-catheter arterial embolization (TAE) plays an important role in treating various diseases. The available embolic agents lack X-ray visibility and do not prevent the reflux phenomenon, thus hindering their application for TAE therapy. Herein, we aim to develop a multifunctional embolic agent that combines the X-ray radiopacity with local procoagulant activity. The barium sulfate nanoparticles (BaSO4 NPs) were synthesized and loaded into the polyvinyl alcohol/chitosan (PVA/CS) to prepare the radiopaque BaSO4/PVA/CS microspheres (MS). Thereafter, thrombin was immobilized onto the BaSO4/PVA/CS MS to obtain the thrombin@BaSO4/PVA/CS MS. The prepared BaSO4/PVA/CS MS were highly spherical with diameters ranging from 100 to 300 μm. In vitro CT imaging showed increased X-ray visibility of BaSO4/PVA/CS MS with the increased content of BaSO4 NPs in the PVA/CS MS. The biocompatibility assessments demonstrated that the MS were non-cytotoxic and possessed permissible hemolysis rate. The biofunctionalized thrombin@BaSO4/PVA/CS MS showed improved hemostatic capacity and facilitated hemostasis in vitro. Additionally, in vivo study performed on a rabbit ear embolization model confirmed the excellent X-ray radiopaque stability of the BaSO4/PVA/CS MS. Moreover, both the BaSO4/PVA/CS and thrombin@BaSO4/PVA/CS MS achieved superior embolization effects with progressive ischemic necrosis on the ear tissue and induced prominent ultrastructural changes in the endothelial cells. The findings of this study suggest that the developed MS could act as a radiopaque and hemostatic embolic agent to improve the embolization efficiency.
Improving tuberculosis surveillance by detecting international transmission using publicly available whole genome sequencing data
Authors: Andrea Sanchini, Christine Jandrasits, Julius Tembrockhaus, Thomas Andreas Kohl, Christian Utpatel, Florian P Maurer, Stefan Niemann, Walter Haas, Bernhard Y Renard, Stefan Kröger
Journal: Eurosurveillance (2021)

IntroductionImproving the surveillance of tuberculosis (TB) is especially important for multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB. The large amount of publicly available whole genome sequencing (WGS) data for TB gives us the chance to re-use data and to perform additional analyses at a large scale.AimWe assessed the usefulness of raw WGS data of global MDR/XDR Mycobacterium tuberculosis isolates available from public repositories to improve TB surveillance.MethodsWe extracted raw WGS data and the related metadata of M. tuberculosis isolates available from the Sequence Read Archive. We compared this public dataset with WGS data and metadata of 131 MDR- and XDR M. tuberculosis isolates from Germany in 2012 and 2013.ResultsWe aggregated a dataset that included 1,081 MDR and 250 XDR isolates among which we identified 133 molecular clusters. In 16 clusters, the isolates were from at least two different countries. For example, Cluster 2 included 56 MDR/XDR isolates from Moldova, Georgia and Germany. When comparing the WGS data from Germany with the public dataset, we found that 11 clusters contained at least one isolate from Germany and at least one isolate from another country. We could, therefore, connect TB cases despite missing epidemiological information.ConclusionWe demonstrated the added value of using WGS raw data from public repositories to contribute to TB surveillance. Comparing the German with the public dataset, we identified potential international transmission events. Thus, using this approach might support the interpretation of national surveillance results in an international context.
Microvolt T-Wave Alternans for Arrhythmia Risk Stratification in Left Ventricular Dysfunction: Which Patients Benefit?⁎⁎Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Authors: Thomas Klingenheben
Journal: Journal of the American College of Cardiology (2007)
Mechanical, compositional and morphological characterisation of the human male urethra for the development of a biomimetic tissue engineered urethral scaffold
Authors: Eoghan M. Cunnane, Niall F. Davis, Connor V. Cunnane, Katherine L. Lorentz, Alan J. Ryan, Jochen Hess, Justin S. Weinbaum, Michael T. Walsh, Fergal J. O'Brien, David A. Vorp
Journal: Biomaterials (2021)
Identification of Suicide Attempt Risk Factors in a National US Survey Using Machine Learning
Authors: Ángel García de la Garza, Carlos Blanco, Mark Olfson, Melanie M. Wall
Journal: JAMA Psychiatry (2021)

<h3>Importance</h3> Because more than one-third of people making nonfatal suicide attempts do not receive mental health treatment, it is essential to extend suicide attempt risk factors beyond high-risk clinical populations to the general adult population. <h3>Objective</h3> To identify future suicide attempt risk factors in the general population using a data-driven machine learning approach including more than 2500 questions from a large, nationally representative survey of US adults. <h3>Design, Setting, and Participants</h3> Data came from wave 1 (2001 to 2002) and wave 2 (2004 to 2005) of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). NESARC is a face-to-face longitudinal survey conducted with a national representative sample of noninstitutionalized civilian population 18 years and older in the US. The cumulative response rate across both waves was 70.2% resulting in 34 653 wave 2 interviews. A balanced random forest was trained using cross-validation to develop a suicide attempt risk model. Out-of-fold model prediction was used to assess model performance, including the area under the receiver operator curve, sensitivity, and specificity. Survey design and nonresponse weights allowed estimates to be representative of the US civilian population based on the 2000 census. Analyses were performed between May 15, 2019, and June 10, 2020. <h3>Main Outcomes and Measures</h3> Attempted suicide in the 3 years between wave 1 and wave 2 interviews. <h3>Results</h3> Of 34 653 participants, 20 089 were female (weighted proportion, 52.1%). The weighted mean (SD) age was 45.1 (17.3) years at wave 1 and 48.2 (17.3) years at wave 2. Attempted suicide during the 3 years between wave 1 and wave 2 interviews was self-reported by 222 of 34 653 participants (0.6%). Using survey questions measured at wave 1, the suicide attempt risk model yielded a cross-validated area under the receiver operator characteristic curve of 0.857 with a sensitivity of 85.3% (95% CI, 79.8-89.7) and a specificity of 73.3% (95% CI, 72.8-73.8) at an optimized threshold. The model identified 1.8% of the US population to be at a 10% or greater risk of suicide attempt. The most important risk factors were 3 questions about previous suicidal ideation or behavior; 3 items from the 12-Item Short Form Health Survey, namely feeling downhearted, doing activities less carefully, or accomplishing less because of emotional problems; younger age; lower educational achievement; and recent financial crisis. <h3>Conclusions and Relevance</h3> In this study, after searching through more than 2500 survey questions, several well-known risk factors of suicide attempt were confirmed, such as previous suicidal behaviors and ideation, and new risks were identified, including functional impairment resulting from mental disorders and socioeconomic disadvantage. These results may help guide future clinical assessment and the development of new suicide risk scales.
Letter to the editor: Checking the pulse of adoptive cell therapy for solid tumors. Thoughts from the abstracts submitted to the 35th Annual Meeting of the Society for the Immunotherapy of Cancer (SITC 2020)
Authors: Martina Markovska, Francesco Marincola
Journal: Journal for ImmunoTherapy of Cancer (2021)

Adoptive cell therapy (ACT) for the treatment of solid malignancies has not met yet the success of hematological malignancies. This is due to additional roadblocks peculiar to its deployment for the former application. While T-cell fitness stands as a prerequisite for all purposes of ACT, selection of optimal tumor-specific antigens, efficient trafficking to neoplastic tissues, and overcoming immune exclusion and/or suppression are challenges pertaining predominantly to solid malignancies. To gain insights about the current interest on the subject in both academia and industry, we surveyed a snapshot of topical activities and checked the pulse of the field by reviewing content extracted from 94 abstracts submitted, under the subject "cellular therapies", to the 35th Anniversary Annual Meeting of the Society for the Immunotherapy of Cancer.
Sewing a Mask
Authors: Wynne Morrison
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 13110: Digenic Mutations in GUCY1A3 and CCT7 Increases Risk of Myocardial Infarction in an Extended Family
Authors: Philipp M Rumpf, Klaus Stark, Ulrike B Esslinger, Marcus Fischer, Elisabeth Graf, Doris Koesling, Frank Kaiser, Cor de Wit, Jurg Ott, Nilesh J Samani, Tim M Strom, Thomas Meitinger, Heribert Schunkert, Christian Hengstenberg, Jeanette Erdmann
Journal: Circulation (2012)

Myocardial infarction (MI) is a life-threatening disease, which results from sudden atherothrombotic occlusion of a coronary artery. Most cases of MI occur sporadically, but sometimes the disease c...