tbuckley/cabot-search huggingface dataset:
Comparison of contractile performance of canine atrial and ventricular muscles.
Authors: FUrthaler, A AWalker, L LHefner, T NJames
Journal: Circulation Research (1975)

This study compared the contractile performance of a canine right atrial trabecula with that of a macroscopically indistinguishable trabecula isolated from the right ventricular apex. The heart was removed from nine mongrel puppies weighing 6-8 kg and placed in Krebs-Ringer's bicarbonate solution. The bathing solution contained only 1.25 mmoles of Ca2+ and was bubbled with a 95% O2-5% CO2 gas mixture. Each atrial trabecula was specially selected from the right atrial appendage. Histologically, these trabeculae showed a remarkable longitudinal orientation of the fibers. At Lmax (the length of the muscle at which developed tension was maximum) under identical conditions of temperature, rate of stimulation, ionic milieu, pH, and O2 and CO2 supply, right atrial trabeculae achieved the same developed and total tensions but in a much shorter time than did ventricular trabeculae. In both muscle groups the maximum developed tension averaged about 2.5 g/mm2. Since Lo (expressed as a fraction of Lmax) was less in a...
Idiopathic ventricular fibrillation: inducibility and beneficial effects of class I antiarrhythmic agents.
Authors: BBelhassen, IShapira, DShoshani, AParedes, HMiller, SLaniado
Journal: Circulation (1987)

Ventricular fibrillation in patients without recognizable heart disease is uncommon and electrophysiologic data on such patients is limited. Over a 7 year period, five patients (three men and two women, ranging in age from 24 to 52 years) without demonstrable heart disease underwent electrophysiologic studies with pharmacologic drug testing because of single (four patients) or multiple (one patient) documented episodes of ventricular fibrillation. The arrhythmic event was unrelated to myocardial ischemia or infarction, metabolic or electrolyte disturbances, drug toxicity, preexcitation, or prolonged QT syndromes. In all three patients receiving no antiarrhythmic drugs and in two pretreated with amiodarone, a rapid poorly tolerated ventricular tachyarrhythmia requiring cardioversion was induced by programmed ventricular stimulation with up to two extrastimuli. In all instances, addition of either oral quinidine or oral disopyramide prevented the induction of sustained ventricular arrhythmias. All five pati...
Adrenaline increases the rate of cycling of crossbridges in rat cardiac muscle as measured by pseudo-random binary noise-modulated perturbation analysis.
Authors: J FHoh, G HRossmanith, L JKwan, A MHamilton
Journal: Circulation Research (1988)

The mechanism of action of adrenaline on cardiac contractility in rat papillary muscles containing V1 and V3 isomyosins was analyzed during barium-activated contractures at 25 degrees C by frequency domain analysis using pseudo-random binary noise-modulated perturbations. The analysis characterizes a frequency (fmin) at which dynamic stiffness of a muscle is a minimum, a parameter that reflects the rate of cycling of crossbridges. We have previously shown that fmin for V1- and V3-containing papillary muscles were 2.1 +/- 0.2 Hz (mean +/- SD) (n = 10) and 1.1 +/- 0.2 Hz (n = 8), respectively, and that these values were independent of the level of activation. The present study's goal was to determine whether the inotropic action of adrenaline was associated with an increased rate of crossbridge cycling. The results show that a saturating dose of adrenaline increased fmin in V1 hearts by 49 +/- 2% (n = 11). The action on V3 hearts was significantly less; the increase in fmin was 26 +/- 2% (n = 6). The increa...
Transcatheter Versus Surgical Aortic Valve Replacement in Patients With Rheumatic Aortic Stenosis
Authors: Amgad Mentias, Marwan Saad, Milind Y. Desai, Amar Krishnaswamy, Venu Menon, Phillip A. Horwitz, Samir Kapadia, Mary Vaughan Sarrazin
Journal: Journal of the American College of Cardiology (2021)

Patients with rheumatic aortic stenosis (AS) were excluded from transcatheter aortic valve replacement (TAVR) trials. The authors sought to examine outcomes with TAVR versus surgical aortic valve replacement (SAVR) in patients with rheumatic AS, and versus TAVR in nonrheumatic AS. The authors identified Medicare beneficiaries who underwent TAVR or SAVR from October 2015 to December 2017, and then identified patients with rheumatic AS using prior validated International Classification of Diseases, Version 10 codes. Overlap propensity score weighting analysis was used to adjust for measured confounders. The primary study outcome was all-cause mortality. Multiple secondary outcomes were also examined. The final study cohort included 1,159 patients with rheumatic AS who underwent aortic valve replacement (SAVR, n = 554; TAVR, n = 605), and 88,554 patients with nonrheumatic AS who underwent TAVR. Patients in the SAVR group were younger and with lower prevalence of most comorbidities and frailty scores. After median follow-up of 19 months (interquartile range: 13 to 26 months), there was no difference in all-cause mortality with TAVR versus SAVR (11.2 vs. 7.0 per 100 person-year; adjusted hazard ratio: 1.53; 95% confidence interval: 0.84 to 2.79; p = 0.2). Compared with TAVR in nonrheumatic AS, TAVR for rheumatic AS was associated with similar mortality (15.2 vs. 17.7 deaths per 100 person-years (adjusted hazard ratio: 0.87; 95% confidence interval: 0.68 to 1.09; p = 0.2) after median follow-up of 17 months (interquartile range: 11 to 24 months). None of the rheumatic TAVR patients, <11 SAVR patients, and 242 nonrheumatic TAVR patients underwent repeat aortic valve replacement (124 redo-TAVR and 118 SAVR) at follow-up. Compared with SAVR, TAVR could represent a viable and possibly durable option for patients with rheumatic AS.
Diagnosis of trifasicular damage following tetralogy of fallot and ventricular septal defect repair.
Authors: S MYabek, J MJarmakani, N KRoberts
Journal: Circulation (1977)

We evaluated the usefulness of the surface electrocardiogram to predict the presence of postoperative trifascicular damage. We used the pre and postoperative electrocardiograms and postoperative His bundle electrograms from 50 patients an average of 3.8 years following tetralogy of Fallot (TF) and ventricular septal defect (VSD) repair. Right bundle branch block (RBBB) and RBBB with left anterior hemiblock (LAH) developed in 88% and 18% respectively, and 22% had transient postoperative complete heart block (CHB). Mean P-A and A-H conduction times were 16.6 and 84.9 msec and were not different from 37 are-matched normal patients and 61 patients with unoperated TF and VSD. The mean H-V conduction time of 48.5 msec was significantly increased compared to the other two groups. Ten postoperative patients had H-V times of 55 msec or greater, indicating trifasicular damage. Of these, five had electrocardiographic bifascicular block (RBBB with LAH) with or without additional 1 degrees A-V block. The remaining fiv...
Nonlinear biphasic relationship between the time constant tau and load
Authors: S Prabhu
Journal: Cardiovascular Research (2000)

To the Editor,

I appreciate the excellent points raised by Leite-Moreira et al. regarding my manuscript examining the load sensitivity of left ventricular (LV) relaxation in heart failure [1], and welcome the opportunity to respond. As has been detailed by these authors and others previously, relaxation behavior is complex and can be influenced by multiple factors including the magnitude of load, the timing of load, and the manner in which the load is applied. This study examined the effect of load on LV relaxation in the intact state during transient reductions in preload while controlling such variables as …
Патогенетична роль оксиду азоту у формуванні різних варіантів гастроезофагеальної рефлюксної хвороби у військовослужбовців
Authors: G.V. Osyodlo, A.P. Burlaka, І.I. Sydorenko, V.S. Potaskalova
Journal: GASTROENTEROLOGY (2013)

У статті наведені огляд літератури та аналіз результатів власних досліджень щодо патогенетичної ролі оксиду азоту у формуванні різних варіантів гастроезофагеальної рефлюксної хвороби у військовослужбовців з урахуванням гістоморфологічної картини слизової оболонки стравоходу.
Antineutrophil and myocardial protecting actions of a novel nitric oxide donor after acute myocardial ischemia and reperfusion of dogs.
Authors: D JLefer, KNakanishi, W EJohnston, JVinten-Johansen
Journal: Circulation (1993)

BACKGROUNDIt has recently been demonstrated that myocardial ischemia and reperfusion results in a marked decrease in the release of nitric oxide (NO) by the coronary endothelium. NO may possess cardioprotective properties, possibly related to inhibition of neutrophil-related activities. We tested the hypothesis that a cysteine-containing nitric oxide donor compound, SPM-5185, would reduce infarct size and inhibit neutrophil-related activities (adherence to coronary vascular endothelium, accumulation).METHODS AND RESULTSThe effects of intracoronary infusion of SPM-5185 were investigated in a 5.5-hour model of myocardial ischemia (1 hour) and reperfusion (4.5 hours) (MI-R) in anesthetized, open-chest dogs. SPM-5185 (500 nmol/L) or saline vehicle was infused for 4.5 hours into the left anterior descending coronary artery (LAD) at the time of reperfusion after 1 hour of LAD occlusion. MI-R in dogs receiving saline vehicle resulted in severe myocardial injury characterized by dyskinesis, a profound elevation o...
Utilization of a Pediatric Sickle Cell Day Hospital By Patients with Sickle Cell Disease and Pain Events Is Associated with a Lower Rate of Inpatient Hospital Admission Compared to Utilization of the Pediatric Emergency Department
Authors: Rochelle Maxwell, Veronika Polishchuk, Jeremy Rosenblum, M. Catherine Driscoll, Kerry A Morrone, Jonathan B. Gill, Michael E. Roth, Deepa Manwani
Journal: Blood (2017)
Congenital Zika Virus Infection
Authors: Marcio Leyser, Osvaldo J. M. Nascimento
Journal: JAMA Neurology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Re: False Positive Uptake in Bilateral Gynecomastia on 68Ga-PSMA PET/CT Scan
Authors: Gozde Daglioz Gorur, Turkay Hekimsoy, Serkan Isgoren
Journal: Clinical Nuclear Medicine (2018)

Department of Nuclear Medicine Kocaeli University School of Medicine Kocaeli, Turkey [email protected] Conflicts of interest and sources of funding: none declared.
Granulocytes cause reperfusion ventricular dysfunction after 15-minute ischemia in the dog.
Authors: REngler, J WCovell
Journal: Circulation Research (1987)

Regional ventricular dysfunction (the stunned myocardium) persists for several hours after 15 minutes of ischemia and reperfusion in the dog. Superoxide-radical-induced damage appears to be one of the mechanisms of this injury. We tested whether granulocytes were a direct source of injury in the stunned myocardium in the 15-minute ischemia dog model. Regional function during agranulocytic extracorporeal coronary perfusion (using Leukopak filters) with ischemia and reperfusion was compared with function during a second period of ischemia and reperfusion after removal of the filters (granulocytopenia). Flow reduction and reperfusion flow, preload, afterload, and inotropic stimulation were the same during agranulocytic and granulocytopenic perfusion. During agranulocytic perfusion, stunning did not occur (greater than 100% of preischemic function during reperfusion), but when the filters were removed and about 10% of the normal granulocyte count was present, stunning occurred with only 76% return of function...
Amplification of flecainide-induced ventricular conduction slowing by exercise. A potentially significant clinical consequence of use-dependent sodium channel blockade.
Authors: SRanger, MTalajic, RLemery, DRoy, SNattel
Journal: Circulation (1989)

Proarrhythmic effects of flecainide acetate have been reported during exercise, but the mechanism for the arrhythmogenic interaction between flecainide and exercise is unknown. We hypothesized that the sinus tachycardia of exercise may enhance flecainide-induced conduction slowing by increasing use-dependent sodium channel blockade, thereby facilitating the occurrence of ventricular reentry. To evaluate the modulation of flecainide's effects by exercise, we studied 19 patients who were receiving therapeutic doses of flecainide for the treatment of cardiac arrhythmias. Sixteen patients underwent treadmill exercise testing by a modified Bruce protocol. During exercise, QRS duration increased progressively from 94 +/- 22 msec (mean +/- SD) at rest to 116 +/- 25 msec (p less than 0.001) at a mean heart rate increase of 84 +/- 32 beats/min. The patient with the greatest QRS increase developed a monomorphic ventricular tachycardia at peak exercise. At rest, the QRS duration after treatment with flecainide incre...
Concealed ventricular parasystole uncovered in the form of ventricular escapes of variable coupling.
Authors: G JNau, A EAldariz, R SAcunzo, P AChiale, M VElizari, M BRosenbaum
Journal: Circulation (1981)

Exit block from a parasystolic focus is recognized when automatic discharges fail to become manifest during the excitable phase of the ventricular cycle. In the present study, an apparently complete exit block and a persistently concealed ventricular parasystole (VP) resulted from an exit refractory period (ExRP) longer than the sinus cycle length. Slowing of the heart rate caused the concealed VP to become apparent in the form of ventricular escapes of variable coupling and as an idioventricular rhythm that failed to show initial warming up. These features reflect the fact that the automatic focus is protected from activity of the sinus impulses, which, however, can induce a prolonged ExRP. Seven cases of concealed VP are discussed. In two, concealment occurred spontaneously during the follow-up of a typical VP; in three, it was provoked by conduction-depressing drugs; and in two, ventricular escapes of varying coupling were shown to represent the manifestation of a concealed and previously unrecognize...
Relation between ventricular and myocyte function with tachycardia-induced cardiomyopathy.
Authors: F GSpinale, B MFulbright, RMukherjee, RTanaka, F ACrawford, M RZile
Journal: Circulation Research (1992)

Chronic supraventricular tachycardia (SVT) causes left ventricular (LV) dilatation and dysfunction. Changes in myocyte function and structure may be important factors in the development of SVT cardiomyopathy. Accordingly, LV function and isolated myocyte structure and function were examined in six pigs with pacing-induced SVT cardiomyopathy (3 weeks at 240 beats per minute) and six control pigs. LV function was examined by simultaneous echocardiography and catheterization, and isolated myocyte function was studied using computer-assisted video microscopy. Indexes of isolated myocyte contractile performance were examined in the unloaded, unattached state (31 control and 24 SVT cells) and after attachment to a basement membrane substrate (65 control and 45 SVT cells). LV fractional shortening and peak +dP/dt significantly decreased in SVT cells compared with control cells (12 +/- 2% versus 28 +/- 2%, and 842 +/- 61 versus 1,216 +/- 119 mm Hg/sec, respectively; p less than 0.05). Isolated myocyte percent sho...
Neutralizing Response against Variants after SARS-CoV-2 Infection and One Dose of BNT162b2
Authors: Yaniv Lustig, Ital Nemet, Limor Kliker, Neta Zuckerman, Ruti Yishai, Sharon Alroy-Preis, Ella Mendelson, Michal Mandelboim
Journal: New England Journal of Medicine (2021)

Vaccination after SARS-CoV-2 Infection Six patients previously infected with the original SARS-CoV-2 virus received the BNT162b2 vaccine. Before vaccination, they had neutralizing activity against ...
Platelet-derived growth factor-BB-induced suppression of smooth muscle cell differentiation.
Authors: B JHolycross, R SBlank, M MThompson, M JPeach, G KOwens
Journal: Circulation Research (1992)

Previously, we demonstrated that treatment of postconfluent quiescent rat aortic smooth muscle cells (SMCs) with platelet-derived growth factor (PDGF)-BB dramatically reduced smooth muscle (SM) alpha-actin synthesis. In the present studies, we focused on the expression of two other SM-specific proteins, SM myosin heavy chain (SM-MHC) and SM alpha-tropomyosin (SM-alpha TM), to determine whether the actions of PDGF-BB were specific to SM alpha-actin or represented a global ability of PDGF-BB to inhibit expression of cell-specific proteins characteristic of differentiated SMCs. SM-MHC and SM-alpha TM expression were assessed by one- or two-dimensional gel electrophoretic analysis of proteins from cells labeled with [35S]methionine, as well as by Northern analysis of mRNA levels. Synthesis of both SM-specific proteins was decreased by 50-70% in PDGF-BB--treated cells as compared with cells treated with PDGF vehicle. Treatment of cells with 10% fetal bovine serum, which produced a mitogenic effect equivalent t...
Comparative value of eight M-mode echocardiographic formulas for determining left ventricular stroke volume. A correlative study with thermodilution and left ventricular single-plane cineangiography.
Authors: GKronik, JSlany, HMösslacher
Journal: Circulation (1979)

Sixty-six consecutive patients without left ventricular volume overload, significant arrhythmia or significant pericardial effusion were examined by M-mode echocardiography immediately before diagnostic left- and right-heart catheterization. Using various echocardiographic measurements, left ventricular stroke volume (SV) was calculated according to eight different echocardiographic formulas (SVE) that have been proposed previously. At catheterization SV was also determined by thermodilution (SVT) and by single-plane left ventricular cineangiography in the right anterior oblique projection (SVA). When comparing SVE with SVT, the four formulas developed to calculate mitral or aortic flow failed (r = 0.10 to 0.54). As expected, poor correlations (r = 0.22 to 0.47) were also found when formulas used to calculate ventricular volumes from the ventricular diameter or SV from the change in diameter (left ventricular formulas) were used in coronary patients with grossly asymmetrical ventricular contraction patter...
Perioperative myocardial infarction after coronary artery bypass surgery. Clinical significance and approach to risk stratification.
Authors: TForce, PHibberd, GWeeks, A JKemper, PBloomfield, DTow, MJosa, SKhuri, A FParisi
Journal: Circulation (1990)

The clinical significance of perioperative myocardial infarction (MI) after coronary artery bypass surgery is not known. Therefore, strategies for the risk stratification of these patients do not exist. This study was undertaken to define the effect of perioperative MI on prognosis after discharge from the hospital and to develop an approach to the risk stratification of these patients. Fifty-nine patients with and 115 patients without perioperative MI were observed for 30 months for the development of cardiac events (death, nonfatal MI, and admission to hospital for unstable angina or congestive heart failure). Patients with perioperative MI were significantly more likely than patients without to have a cardiac event (31% versus 12%, p less than 0.01) and multiple events (19% versus 1%, p less than 0.001). Cox regression analysis identified two independent predictors of cardiac events other than perioperative MI (relative risk, 2.7): inadequate revascularization (relative risk, 3.5) and depressed (less t...
Long-Term Safety and Efficacy of Empagliflozin, Sitagliptin, and Metformin : An active-controlled, parallel-group, randomized, 78-week open-label extension study in patients with type 2 diabetes.
Authors: Ele) Ferrannini, Berk (Andreas), Hantel (Stefan), Pinnetti (Sabine)
Journal: Diabetes Care (2013)
Catherine B G Strang
Authors: Alex Morrow
Journal: BMJ (2021)

Born in Leith, Edinburgh, Catherine Barbara Grace Strang (nee Sinclair) attended James Gillespie’s School before entering medical school, where her studies were interrupted for two years by the illness and untimely death of her father. After several years in hospital medicine—including paediatrics, obstetrics, and gynaecology—she moved into general practice in Whitley Bay, Northumberland, in 1952 before working for five years as an assistant medical officer of health in the same area with duties in maternity and child health. …
Technical And Clinical Outcomes Of Using Single Wide-Caliber Double Pigtail Stent For Endoscopic Ultrasound-Guided Pancreatic Pseudocyst Drainage, Egyptian Multicenter Prospective Study
Authors: E Ghoneem, H Okasha, H Attallah, G Shiha, K Ragab
Journal: Endoscopy (2021)

Aims EUS-guided cystogastrostomy is the current accepted practice for pancreatic pseudocyst drainage with insertion of two or more double pigtail stents. There is no much work on the efficacy of using single wide caliber double pigtail stent aiming to decrease the time, complications and accessories used in the procedure.
Blood velocity distribution in the human ascending aorta.
Authors: LSegadal, KMatre
Journal: Circulation (1987)

Mapping of blood velocities across the lumen of the ascending aorta was performed in eight patients during open-heart surgery. A Doppler ultrasound probe was constructed to measure velocities in 2 mm steps from the maximum convexity to the maximum concavity of aorta, 6 to 7 cm above the aortic valve. In five patients with angina and normal aortic valves, velocity profiles were very similar and showed the following main features: a skewed peak systolic velocity profile with the highest velocity along the left posterior wall, a bidirectional velocity profile in late systole and early diastole with retrograde velocities along the left posterior wall, and a sustained antegrade flow along the convexity well into diastole. The resultant mean velocity profile had the highest velocity at the convex side and a central minimum velocity. In patients with Medtronic-Hall tilting disc prostheses, where the larger opening was oriented backwards and to the right, mean flow velocity profile was skewed in the opposite dire...