tbuckley/cabot-search huggingface dataset:
Retraction of the Letter: “Comment on ‘CD4 <sup>+</sup> T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy’ ”
Authors: Robbert van der Most, Martine Wettendorff, Bruce Innis, Emmanuel Hanon
Journal: Science Translational Medicine (2014)

Post date 24 September 2014

Our Letter “Comment on ‘CD4+ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy’ ” ([ 1 ][1]) discussed the article by De la Herran-Arita et al . ([ 2 ][2]). That article provided evidence for CD4+ T
Body surface distribution of abnormally low QRST areas in patients with Wolff-Parkinson-White syndrome. Evidence for continuation of repolarization abnormalities before and after catheter ablation.
Authors: MHirai, NTsuboi, HHayashi, MIto, YInden, HHirayama, TIto, TYanagawa, HSano, TKondo
Journal: Circulation (1993)

BACKGROUNDWhether the Wolff-Parkinson-White syndrome (WPW) is associated with repolarization abnormalities is controversial. The QRST isointegral map (I-map) is theoretically independent of the activation sequence and dependent on repolarization properties. There have been no reports concerning the effects of radiofrequency (RF) catheter ablation of accessory pathway (AP) on repolarization properties analyzed by I-mapping.METHODS AND RESULTSI-maps were constructed from data recorded in 38 patients with WPW to investigate repolarization properties and their body surface distribution in a physiological state, without pharmacological influences, and in 13 ablated patients to elucidate the effects of RF ablation on repolarization properties. Patients were divided into three groups: group A, 15 patients with type A WPW (left-sided AP); group B, 10 patients with type B (right-sided AP); and group C, 13 patients who were successfully ablated. Group C consisted of three subgroups: subgroup CA, 7 patients with typ...
Effects of local reduction in pressure on distensibility and composition of cerebral arterioles.
Authors: G LBaumbach, J ESiems, D DHeistad
Journal: Circulation Research (1991)

This study examined effects of local reductions in mean and pulse pressures on cerebral arterioles in normotensive Wistar-Kyoto rats (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP). WKY and SHRSP underwent clipping of one carotid artery at 1 month of age. At 10-12 months of age, mechanics of pial arterioles were examined in vivo in anesthetized rats. Bilateral craniotomies were performed to expose pial arterioles in the sham and clipped cerebral hemispheres. Stress-strain relations were calculated from measurements of pial arteriolar pressure (servo null), diameter, and cross-sectional area of the arteriolar wall. Point counting stereology was used to quantitate individual components in the arteriolar wall. Before deactivation of smooth muscle with EDTA, mean (Pm) and pulse (Pp) pressures were significantly less (p less than 0.05) in clipped than in sham arterioles in WKY (Pm, 63 +/- 2 versus 73 +/- 2 mm Hg; Pp, 23 +/- 3 versus 30 +/- 3 mm Hg) and SHRSP (Pm, 94 +/- 4 versus 110 +/- 4 mm Hg;...
Nuclear Cardiology. Principles and Methods.
Journal: Annals of Internal Medicine (1978)

I Fundamentals.- Basic Anatomy of the Normal and Diseased Heart.- Assessment of Left Ventricular Function: Current Methods and Clinical Significance.- Radiopharmaceuticals for Cardiovascular Investigations.- II Shunt Detection in Congenital Heart Disease.- Scintiangiographic and Probe Systems in the Detection of Cardiac Shunts.- Detection of Left-to-Right Shunts by Inhalation of Oxygen-15-Labeled Carbon Dioxide.- III Evaluation of Myocardial Blood Flow and Disease.- Myocardial Energetics.- Potassium-43 and Rubidium-81 Myocardial Imaging at Rest, at Exercise, and During Angina Pectoris.- Myocardial Imaging at Rest and During Stress with MAA or Microspheres.- Measurement of Myocardial Blood Flow Using 133Xe.- Myocardial Perfusion Imaging with MAA Following Coronary Artery Surgery.- Rest and Exercise Myocardial Imaging in the Assessment of the Postoperative Cardiac Patient.- Acute Myocardial Infarct Imaging with 99mTc Stannous Pyrophosphate.- Myocardial Imaging with Thallium-201.- IV Evaluation of Ventricular Function.- Functional Aspects of Myocardial and Valvular Disease: Clinical Correlations.- Techniques for Heart-Lung Imaging.- Noninvasive Measurement of Left-Ventricular Performance Utilizing an Anger Camera-Left-Ventricular Ejection Fraction.- Simplified Techniques for Radioangiographic Analysis.- Value of Combined Hemodynamic and Radiocardiographic Studies in Acute Respiratory Failure.- The Use of C15O2 in the Evaluation of Cardiac Abnormalities.- Radioactive Gases in the Evaluation of Left Ventricular Function.- Early Effect of Cardiac Surgery on Left-Ventricular Ejection Fraction.- V Radioimmunoassay.- Role of Radioimmunoassay in the Cardiac Patient-Principles and Applications.
Differential effects of transforming growth factor-beta 1 and phorbol myristate acetate on cardiac fibroblasts. Regulation of fibrillar collagen mRNAs and expression of early transcription factors.
Authors: MEghbali, RTomek, V PSukhatme, CWoods, BBhambi
Journal: Circulation Research (1991)

Cardiac fibroblasts are responsible for synthesis and deposition of fibrillar collagen types I and III. Transforming growth factor-beta 1 (TGF-beta 1) has been proved to increase collagen biosynthesis in various systems, both in vivo and in vitro. We have investigated the effect of TGF-beta 1 on collagen gene expression in cultured cardiac fibroblasts and have compared this effect with that of a mitogenic agent, phorbol myristate acetate (PMA). The regulation of collagen types I and III gene expression was examined by using cDNA probes to rat alpha 2 (I) and mouse alpha 1 (III) procollagens. Quiescent cultured cardiac fibroblasts from rabbit heart were treated with TGF-beta 1 (10-15 ng/ml) and PMA (200 ng/ml). After 24 hours of treatment with TGF-beta 1, the abundance of mRNA for pro-alpha 2 (I) and pro-alpha 1 (III) collagens was increased by 112% (p less than 0.001) and 97% (p = 0.05), respectively, in treated fibroblasts compared with untreated cells. However, PMA-treated cells showed an opposite respo...
Can coronary angiography predict the site of a subsequent myocardial infarction in patients with mild-to-moderate coronary artery disease?
Authors: W CLittle, MConstantinescu, R JApplegate, M AKutcher, M TBurrows, F RKahl, W PSantamore
Journal: Circulation (1988)

To help determine if coronary angiography can predict the site of a future coronary occlusion that will produce a myocardial infarction, the coronary angiograms of 42 consecutive patients who had undergone coronary angiography both before and up to a month after suffering an acute myocardial infarction were evaluated. Twenty-nine patients had a newly occluded coronary artery. Twenty-five of these 29 patients had at least one artery with a greater than 50% stenosis on the initial angiogram. However, in 19 of 29 (66%) patients, the artery that subsequently occluded had less than a 50% stenosis on the first angiogram, and in 28 of 29 (97%), the stenosis was less than 70%. In every patient, at least some irregularity of the coronary wall was present on the first angiogram at the site of the subsequent coronary obstruction. In only 10 of the 29 (34%) did the infarction occur due to occlusion of the artery that previously contained the most severe stenosis. Furthermore, no correlation existed between the severi...
Hemodynamic changes in the peripheral circulation after repeat low density lipoprotein apheresis in familial hypercholesterolemia.
Authors: PRubba, AIannuzzi, APostiglione, NScarpato, SMontefusco, AGnasso, GNappi, CCortese, MMancini
Journal: Circulation (1990)

Repeat low density lipoprotein (LDL) apheresis and blood flow determinations in the forearm and leg were performed in 10 patients (age range, 13-49 years; four male, six female) with familial hypercholesterolemia (eight homozygous, two heterozygous). To perform LDL apheresis, plasma was first separated by a polysulphone hollow fiber filter; then, LDL was selectively removed from plasma by dextran sulphate cellulose beads packed in columns. Blood flows in the forearm and leg were determined at rest and during a reactive hyperemia test (peak flow). This test was performed noninvasively by a strain-gauge plethysmograph with semicontinuous registration of arterial blood flow variables before the first apheresis and 3 weeks after the last of six procedures for apheresis. Resting arterial blood flows in the forearm and leg were slightly increased after repeat LDL apheresis (p less than 0.05). Peak blood flow in the leg significantly increased (+34%, p less than 0.01). No change in peak blood flow in the forearm...
Antisense nonmuscle myosin heavy chain and c-myb oligonucleotides suppress smooth muscle cell proliferation in vitro.
Authors: MSimons, R DRosenberg
Journal: Circulation Research (1992)

Smooth muscle cell (SMC) proliferation is a poorly understood process that plays a critical role in several pathological states, including atherosclerosis and hypertension. Recent work suggests that the oncogene c-myb and myosin, a ubiquitous cytoskeletal protein, may be directly involved in this process. We have used antisense nonmuscle myosin heavy chain (NMMHC) or c-myb phosphorothiolate oligonucleotides to inhibit proliferation of SMCs in vitro. The suppression of growth is accompanied by reductions in the concentrations of NMMHC and c-myb mRNAs as well as decreases in the levels of the corresponding proteins. The specificity of the antiproliferative effect is underscored by the absence of any detectable growth inhibition with sense NMMHC or c-myb phosphorothiolate oligonucleotides, an antisense c-myb mismatch phosphorothiolate oligonucleotide, or an antisense thrombomodulin phosphorothiolate oligonucleotide. Furthermore, the treatment of SMCs with antisense phosphorothiolate oligonucleotides for as l...
Diastolic coronary artery pressure-flow relations in the dog.
Authors: R FBellamy
Journal: Circulation Research (1978)

Conscious dogs were used to investigate the relations between aortic (Pa) pressure and coronary flow (F) during individual diastoles. When the dogs were in a semibasal state, coronary pressure-flow relations were described by a family of lines, and diastolic flow was a linear function of aortic pressure. For a given perfusion pressure, higher flows were associated with lines of progressively greater slope and lower zero flow pressure intercept (Pf=0). Zero flow pressure intercepts were estimated by extrapolation and found to vary between 20 and 50 mm Hg, depending on the magnitude of flow. The zero flow pressure may represent the height of a vascular waterfall caused by vasomotor tone with the resistance-controlling coronary flow being (P-Pf=0).F-1. Interventions that decrease vasomotor tone increase coronary flow by both decreasing vascular resistance and increasing the perfusion pressure gradient. The gradient increases because the effective coronary back pressure is the height of the vascular waterfall...
Assessment of regional myocardial and renal blood flow with copper-PTSM and positron emission tomography.
Authors: M EShelton, M AGreen, C JMathias, M JWelch, S RBergmann
Journal: Circulation (1990)

We recently demonstrated in isolated, perfused hearts that radiolabeled pyruvaldehyde bis(N4-methylthiosemicarbazonato)copper(II) (Cu-PTSM) is well extracted throughout a range of conditions including ischemia, hypoxia, and hyperemia. Once extracted, binding of radioactivity by the isolated heart was essentially irreversible, giving this tracer microspherelike qualities. Because Cu-PTSM can be readily prepared with the generator-produced positron-emitting copper 62 and other gamma- or positron-emitting copper radionuclides, we evaluated its usefulness for measuring regional myocardial and renal blood flow in vivo in intact dogs at rest, after ischemia, or after coronary hyperemia was induced by intravenous administration of dipyridamole. After intravenous administration of radiolabeled Cu-PTSM, the tracer cleared rapidly from the blood. Myocardial uptake of single photon-emitting 67Cu-labeled Cu-PTSM was measured directly in myocardial samples 15 minutes after tracer administration, and it increased propo...
Acute Cholangitis: Etiological and Therapeutic Aspects
Authors: Y Essadni, M Borahma, N Lagdali, I Benelbarhdadi, FZ Ajana
Journal: Endoscopy (2021)

Aims Acute cholangitis (AC) is an infection of the bile duct system. The main etiologies are biliary stones and malignant obstructions. The ultimate treatment is the endoscopic drainage (ED). Our work aimed to assess the etiological and therapeutic aspects of cholangitis in our center.
Combined influence of ventricular loading and relaxation on the transmitral flow velocity profile in dogs measured by Doppler echocardiography.
Authors: C YChoong, V MAbascal, J DThomas, J LGuerrero, SMcGlew, A EWeyman
Journal: Circulation (1988)

The relation of the Doppler transmitral flow velocity profile to left ventricular loading conditions and diastolic properties remains poorly described. We studied seven adult mongrel dogs with an open-chest right heart bypass model in which left atrial pressure, representing preload, was varied by controlling blood flow into the pulmonary artery and left ventricular systolic pressure, representing afterload, was controlled independently by pumping blood into or from the femoral arteries. Heart rate was kept constant by crushing the sinus node and pacing the right atrium. Mitral inflow velocity profiles were measured by pulsed-wave Doppler echocardiography at multiple left atrial and left ventricular systolic pressures. In individual dogs, the peak E-wave velocity increased linearly with increasing left atrial V-wave pressure at constant left ventricular systolic pressure and decreased with increasing left ventricular systolic pressure at constant left atrial pressure. Stepwise multiple linear regression a...
Volume changes in sarcoplasmic reticulum of rat hearts perfused with hypertonic solutions.
Authors: EPage, JUpshaw-Earley
Journal: Circulation Research (1977)

To explore whether morphometry of intracellular membrane-limited subcompartments can be used to follow physiological volume changes in such subcompartments in hearts rapidly fixed by perfusion fixation, we have measured osmotically induced volume changes in electron micrographs of longitudinally oriented sarcoplasmic reticulum (LSR) and terminal cisterns (TC) of rat left ventricular myocardial cells. Vascular perfusion with solutions whose osmolality varied from 0.67 to 1.88 isomolal showed that in the hyperosmolal range LSR volume decreased linearly. Approximately 79% of LSR luminal volume participated in the osmotic rey unresponsive. By contrast, we found that the TC responded by dilation when hearts were perfused with hypersomolal NaCl, NaI, LiCl, or sucrose. Furthermore, with hyperosmolal NaCl the dilation developed within 1 minute; its rate and extent of development were concentration-dependent; it manifested an obligate association with prior or concomitant T-tubular dilation and was not readily rev...
Left ventricular hypertrophy associated with chronic cocaine abuse.
Authors: M EBrickner, J EWillard, E JEichhorn, JBlack, P AGrayburn
Journal: Circulation (1991)

BACKGROUNDThis study was performed to determine whether chronic cocaine abuse is associated with left ventricular hypertrophy in humans.METHODS AND RESULTSA consecutive series of 40 chronic cocaine abusers 23-44 years old who were enrolled in an inpatient drug rehabilitation program were considered for the study. Subjects with elevated resting blood pressure (n = 4) or a history of hypertension (n = 3) were excluded. Technically adequate two-dimensional echocardiograms were obtained in 30 cocaine abusers and 30 age- and race-matched normal control subjects. All subjects were men, and the groups were similar with regard to resting blood pressure, height, weight, and body surface area. All echocardiograms were read in blinded fashion, and left ventricular mass was calculated by the area-length method. Left ventricular cavity dimensions and wall motion were normal in all subjects. Left ventricular mass index was higher in the cocaine group (103 +/- 24 versus 77 +/- 14 g/m2, p = 0.0001). Posterior wall thickn...
Heparin inhibits collagenase gene expression mediated by phorbol ester-responsive element in primate arterial smooth muscle cells.
Authors: Y PAu, K FMontgomery, A WClowes
Journal: Circulation Research (1992)

Heparin is a potent inhibitor of arterial smooth muscle cell (SMC) migration and proliferation in vivo and in vitro. We propose that heparin affects these SMC functions by interfering with either the expression or the activity of secreted proteases required for cell movement. We have reported that heparin selectively inhibits the expression of tissue-type plasminogen activator in SMCs during mitogenesis. In this study we show that the gene expression of another kind of protease, interstitial collagenase, is induced by fetal bovine serum and is also suppressed by heparin. The inhibitory effect on the induced collagenase mRNA is specific to heparin-like molecules and does not depend on the anticoagulant activity of heparin. The induction of the collagenase gene depends on the protein kinase C pathway, since it can be induced by phorbol esters such as phorbol 12-myristate 13-acetate and blocked by inhibitors such as H-7 and staurosporine. In transient transfection assays with chloramphenicol acetyltransferas...
Temozolomide-induced hypermutation is associated with distant recurrence and reduced survival after high-grade transformation of low-grade <i>IDH</i>-mutant gliomas
Authors: Yao Yu, Javier Villanueva-Meyer, Matthew R Grimmer, Stephanie Hilz, David A Solomon, Serah Choi, Michael Wahl, Tali Mazor, Chibo Hong, Anny Shai, Joanna J Phillips, Bruce H Wainer, Michael McDermott, Daphne Haas-Kogan, Jennie W Taylor, Nicholas Butowski, Jennifer L Clarke, Mitchel S Berger, Annette M Molinaro, Susan M Chang, Joseph F Costello, Nancy Ann Oberheim Bush
Journal: Neuro-Oncology (2021)

Chemotherapy improves overall survival after surgery and radiotherapy for newly diagnosed high-risk IDH-mutant low-grade gliomas (LGGs), but a proportion of patients treated with temozolomide (TMZ) will develop recurrent tumors with TMZ-induced hypermutation. We aimed to determine the prevalence of TMZ-induced hypermutation at recurrence and prognostic implications.We sequenced recurrent tumors from 82 patients with initially low-grade IDH-mutant gliomas who underwent reoperation and correlated hypermutation status with grade at recurrence and subsequent clinical outcomes.Hypermutation was associated with high-grade disease at the time of reoperation (OR 12.0 95% CI 2.5-115.5, P = .002) and was identified at transformation in 57% of recurrent LGGs previously exposed to TMZ. After anaplastic (grade III) transformation, hypermutation was associated with shorter survival on univariate and multivariate analysis (HR 3.4, 95% CI 1.2-9.9, P = .024), controlling for tumor grade, subtype, age, and prior radiotherapy. The effect of hypermutation on survival after transformation was validated in an independent, published dataset. Hypermutated (HM) tumors were more likely to develop discontiguous foci of disease in the brain and spine (P = .003). To estimate the overall incidence of high-grade transformation among low-grade IDH-mutant tumors, data from a phase II trial of TMZ for LGG were analyzed. Eight-year transformation-free survival was 53.8% (95% CI 42.8-69.2), and 61% of analyzed transformed cases were HM.TMZ-induced hypermutation is a common event in transformed LGG previously treated with TMZ and is associated with worse prognosis and development of discontiguous disease after recurrence. These findings impact tumor classification at recurrence, prognostication, and clinical trial design.
The relationship of white cell count, platelet count, and hematocrit to cigarette smoking in adolescents: the Oslo Youth Study.
Authors: G STell, R HGrimm, O DVellar, LTheodorsen
Journal: Circulation (1985)

This article reports on the relationship between cigarette smoking, white blood cell count (WBC), platelet count (PC), and hematocrit in a Norwegian adolescent population. Data were obtained on 439 youths, 14 to 16 years old, as part of the Oslo Youth Study, an investigation of risk factors and behaviors for cardiovascular disease and cancer among adolescents. Analyses of covariance, controlling for height, weight, age, sexual maturation, high-density lipoprotein (HDL) cholesterol, and hematocrit revealed that both male and female regular smokers (those reporting smoking at least once a week) had significantly higher mean WBCs. Male regular smokers also had significantly higher PCs than nonsmokers, and female regular smokers had higher PCs than young women who smoked less often than once a month. Hematocrit, after adjustment for height, weight, age, sexual maturation, and HDL cholesterol, was significantly lower in male regular smokers, while female regular smokers had higher hematocrit values than nonsmo...
Genetically engineered endothelial cells remain adherent and viable after stent deployment and exposure to flow in vitro.
Authors: M YFlugelman, RVirmani, M BLeon, R LBowman, D ADichek
Journal: Circulation Research (1992)

Intravascular stents, currently in experimental human use for recurrent arterial stenosis, are plagued by subacute thrombosis. As a therapeutic approach to stent-related thrombosis, we and others have suggested coating stents with endothelial cells before implantation. In a previous study we demonstrated the feasibility of coating stents with endothelial cells that were genetically modified to secrete large amounts of human tissue plasminogen activator. In the present study we attempted both to develop a clinically applicable protocol for stent seeding and to test whether seeded cells would remain adherent to stents after exposure to pulsatile flow. Endothelial cells were harvested from the saphenous veins of sheep with survival of the donor animals. Harvested cells were transduced with a retroviral vector containing a marker gene and seeded onto catheter-mounted stents under sterile conditions. Scanning electron microscopy revealed complete coverage of the stent surfaces by seeded cells. Stents were expa...
The coronary arteries and left ventricle in clinically isolated angina pectoris: a necropsy analysis.
Authors: W CRoberts
Journal: Circulation (1976)

Certain clinical and morphologic observations are described in 27 patients with severe isolated angina pectoris of either the stable (five patients) or the unstable form (22 patients). Twenty-four patients died during or shortly after cardiac operations designed to relieve angina pectoris and three died during cardiac catheterization. During life none had had clinical evidence of acute myocardial infarction or congestive cardiac failure. At necropsy, each had diffuse, extensive coronary atherosclerosis with severe luminal narrowing: the lumens of at least two, an average of three, of the four major epicardial coronary arteries were narrowed greater than 75% in cross-sectional area by old atherosclerotic plaques. Despite the severe coronary narrowing, there was little myocardial damage. Left ventricular scarring (excluding papillary muscle) was observed grossly in only 14 (52%) of the 27 patients and in each it involved only a small portion of myocardial wall. The left ventricular cavity was of normal size...