tbuckley/cabot-search huggingface dataset:
Clinical Trial Design Principles and Outcomes Definitions for Device-Based Therapies for Hypertension: A Consensus Document From the Hypertension Academic Research Consortium
Authors: David E. Kandzari, Felix Mahfoud, Michael A. Weber, Raymond Townsend, Gianfranco Parati, Naomi D.L. Fisher, Melvin D. Lobo, Michael Bloch, Michael Böhm, Andrew S.P. Sharp, Roland E. Schmieder, Michel Azizi, Markus P. Schlaich, Vasilios Papademetriou, Ajay J. Kirtane, Joost Daemen, Atul Pathak, Christian Ukena, Philipp Lurz, Guido Grassi, Martin Myers, Aloke V. Finn, Marie-Claude Morice, Roxana Mehran, Peter Jüni, Gregg W. Stone, Mitchell W. Krucoff, Paul K. Whelton, Konstantinos Tsioufis, Donald E. Cutlip, Ernest Spitzer
Journal: Circulation (2022)

The clinical implications of hypertension in addition to a high prevalence of both uncontrolled blood pressure and medication nonadherence promote interest in developing device-based approaches to hypertension treatment. The expansion of device-based therapies and ongoing clinical trials underscores the need for consistency in trial design, conduct, and definitions of clinical study elements to permit trial comparability and data poolability. Standardizing methods of blood pressure assessment, effectiveness measures beyond blood pressure alone, and safety outcomes are paramount. The Hypertension Academic Research Consortium (HARC) document represents an integration of evolving evidence and consensus opinion among leading experts in cardiovascular medicine and hypertension research with regulatory perspectives on clinical trial design and methodology. The HARC document integrates the collective information among device-based therapies for hypertension to better address existing challenges and identify unmet needs for technologies proposed to treat the world's leading cause of death and disability. Consistent with the Academic Research Consortium charter, this document proposes pragmatic consensus clinical design principles and outcomes definitions for studies aimed at evaluating device-based hypertension therapies.
OPTIMZIED CT SCANNING PROTOCOL OF THE LEFT ATRIUM PRIOR TO RADIOFREQUENCY CATHETER ABLATION IN PATIENTS WITH ATRIAL FIBRILLATION
Authors: Tomasz Jadczyk, Jiri Wolf, Martin Pesl, Filip Soucek, František Lehar, Jiri Jez, Tomas Kulik, Bohdan Tyshchenko, Silvie Belaskova, Petr Ourednicek, Guido Caluori, Miroslav Novak, Zdenek Starek
Journal: Journal of the American College of Cardiology (2022)
Past COVID-19 and immunosuppressive regimens affect the long-term response to anti-SARS-CoV-2 vaccination in liver transplant recipients
Authors: Pierluigi Toniutto, Edmondo Falleti, Sara Cmet, Annarosa Cussigh, Laura Veneto, Davide Bitetto, Ezio Fornasiere, Elisa Fumolo, Carlo Fabris, Assunta Sartor, Roberto Peressutti, Francesco Curcio, Laura Regattin, Lucrezia Grillone
Journal: Journal of Hepatology (2022)
A call for an immediate ceasefire and peaceful end to the Russian aggression against Ukraine
Authors: Gavin Yamey, Akshaya Neil Arya, Zulfiqar A Bhutta, Sara Causevic, Carolyn Chisadza, Sara Fewer, Peter Friberg, Siri Gloppen, Debarati Guha-Sapir, Tarja Halonen, Steven J Hoffman, Ana Langer, Minna Lyytikäinen, Ben Oppenheim, Ole Petter Ottersen, Valerie Percival, Idil Shekh Mohamed, Oskar Timo Thoms
Journal: The Lancet (2022)
RADIATION DOSE REDUCTION FOR DYNAMIC SPECT IMAGING FOR ABSOLUTE MYOCARDIAL BLOOD FLOW MEASUREMENT
Authors: Lewis Han, Clare Carey, Annika Kelly, Elizabetta Cerudelli, Felix Keng, Masao Miyagawa, Hagit Ratner, Terrence D. Ruddy, R. Glenn Wells
Journal: Journal of the American College of Cardiology (2022)
Use of Neural Machine Translation Software for Patients With Limited English Proficiency to Assess Postoperative Pain and Nausea
Authors: Ravish Kapoor, German Corrales, Manuel P. Flores, Lei Feng, Juan P. Cata
Journal: JAMA Network Open (2022)

Outcome Patients, No. (%) (N = 30) Primary end point Able to use application at least once for Pain Yes 29 (96.7)No 1 (3.3)Nausea Yes 30 (100) No 0 Pain and nausea Yes 29 (96.7)No 1 (3.3)Failed at least once overall for Pain Yes 2 (6.7)No 28 (93.3)Nausea Yes 1 (3.3)No 29 (96.7)Pain and nausea Yes 4 (13.3)No 26 (86.7)Did not ever fail Yes 23 (76.7)No 7 (23.3)First assessment attempt successful for Pain Yes 25 (83.3)
Natural and Modified History of Atrioventricular Valve Regurgitation in Patients With Fontan Circulation
Authors: Gregory King, Edward Buratto, David S. Celermajer, Leeanne Grigg, Nelson Alphonso, Terry Robertson, Andrew Bullock, Julian Ayer, Ajay Iyengar, Yves d’Udekem, Igor E. Konstantinov
Journal: Journal of the American College of Cardiology (2022)
DIAGNOSING ST SEGMENT ELEVATION MI (STEMI) IN A PATIENT WITH MYOTONIC DYSTROPHY WITH BIVENTRICULAR PACED RHYTHM
Authors: Nitish Sharma, Ibragim Al-Seykal, Ajay Mishra, Sanjeev B. Goyal, Saif Anwaruddin, Vijay Sheldon
Journal: Journal of the American College of Cardiology (2022)
COVID-19 AND HEART: ASSESSMENT OF TROPONIN AND CARDIOVASCULAR COMORBIDITIES AS PROGNOSTIC MARKERS IN PATIENTS HOSPITALIZED FOR COVID-19 IN A TERTIARY CENTER IN BRAZIL
Authors: Henrique Pinesi, Fernando Giugni, Bruna Scarpa, Fabio Grunspun Pitta, Cibele Larrosa Garzillo, Eduardo Gomes Lima, Roberto Kalil, Carlos V. Serrano
Journal: Journal of the American College of Cardiology (2022)
ASSOCIATION OF SODIUM/GLUCOSE COTRANSPORTER-2 INHIBITORS WITH OUTCOMES IN PATIENTS WITH TYPE 2 DIABETES AND ATRIAL FIBRILLATION
Authors: Annie Brewerton, Husam Mohamed Abdel-Qadir, Dennis T. Ko, Douglas Lee, Sheldon M.S. Singh, Cynthia Jackevicius, Paul Dorian, Peter Austin, Lu Han, Iliana Lega
Journal: Journal of the American College of Cardiology (2022)
CLO22-033: Clinicopathologic and Sociodemographic Factors Associated With Late Relapse Triple Negative Breast Cancer
Authors: Adith S. Abraham, Carlos H. Barcenas, Richard J. Bleicher, Adam L. Cohen, Sara H. Javid, Ellis G. Levine, Nancy U. Lin, Beverly Moy, Joyce Niland, Antonio C. Wolff, Michael J. Hassett, Daniel G. Stover, Sarah Asad
Journal: Journal of the National Comprehensive Cancer Network (2022)
PREVALENCE OF THORACIC AORTIC ANEURYSM IN PATIENTS REFERRED FOR NO-CHARGE CORONARY ARTERY CALCIUM SCORING: INSIGHTS FROM THE CLARIFY REGISTRY
Authors: Tasveer Khawaja, Sadeer G. Al-Kindi, Nour Tashtish, Imran Rashid, Matthew Janko, Cristian Baeza, Jae Cho, Robert C. Gilkeson, Sanjay Rajagopalan
Journal: Journal of the American College of Cardiology (2022)
USING ARTIFICIAL INTELLIGENCE TO ACCURATELY PREDICT ALL-CAUSE DEATH OR READMISSION FOR DECOMPENSATED HEART FAILURE WITH PRESERVED EJECTION FRACTION
Authors: Patrick Prud’Homme, Gabriel Brault, Laurence Pusca, Roxanne Coderre, Marianne Tétreault-Langlois, Hugo Lortie, Michel Nguyen, Serge Lepage
Journal: Journal of the American College of Cardiology (2022)
Self‐Assembly of Naturally Small Molecules into Supramolecular Fibrillar Networks for Wound Healing
Authors: Haibo Huang, Wei Gong, Xinchuang Wang, Wanying He, Yiyang Hou, Jiangning Hu
Journal: Advanced Healthcare Materials (2022)

Abstract Self‐assemblies of bioactively natural compounds into supramolecular hydrogels without structural modifications are of interest to improve their sustained releases and bioavailabilities in vivo. However, it is still a formidable challenge to dig out such a naturally small molecule with a meticulous structure which can be self‐assembled to form a hydrogel for biomedical applications. Here, a new hydrogel consisting only of gallic acid (GA) via π – π stacking and hydrogen bond interactions, whereas none of GA analogues can form the similar supramolecular hydrogels, is reported. This interesting phenomenon is intriguing to further investigate the potential applications of GA hydrogels in wound healing. Notably, this GA hydrogel has rod‐like structures with lengths varying from 10 to 100 µm. The biocompatibility and antibacterial tests prove that this well‐assembled GA hydrogel has no cytotoxicity and excellent antibacterial activities against Escherichia coli and Staphylococcus aureus . Moreover, the GA hydrogel can significantly accelerate the process of wound healing with or without bacterial infections by mediation of inflammation signaling pathways. It is believed that the current study may shed a new light on the design of a supramolecular hydrogel based on self‐assemblies of naturally small molecules to improve their bioavailabilities and diversify their uses in biomedical applications.
Expected phenotypes and expert rules are important complements to antimicrobial susceptibility testing
Authors: Sören Gatermann, Shampa Das, Luc Dubreuil, Christian G. Giske, Gunnar Kahlmeter, Gerard Lina, Christoffer Lindemann, Alasdair MacGowan, Joseph Meletiadis, Gian Maria Rossolini, John Turnidge, Rafael Cantón
Journal: Clinical Microbiology and Infection (2022)
Female erectile tissues and sexual dysfunction after pelvic radiotherapy: A scoping review
Authors: Deborah C. Marshall, Elizabeth S. Tarras, Ayesha Ali, Julie Bloom, Mylin A. Torres, Jenna M. Kahn
Journal: CA A Cancer Journal for Clinicians (2022)

Abstract Sexual function is a vital aspect of human health and is recognized as a critical component of cancer survivorship. Understanding and evaluating the impacts of radiotherapy on female sexual function requires precise knowledge of the organs involved in sexual function and the relationship between radiotherapy exposure and sexual tissue function. Although substantial evidence exists describing the impact of radiotherapy on male erectile tissues and related clinical sexual outcomes, there is very little research in this area in females. The lack of biomedical data in female patients makes it difficult to design studies aimed at optimizing sexual function postradiotherapy for female pelvic malignancies. This scoping review identifies and categorizes current research on the impacts of radiotherapy on normal female erectile tissues, including damage to normal functioning, clinical outcomes of radiation‐related female erectile tissue damage, and techniques to spare erectile tissues or therapies to treat such damage. An evaluation of the evidence was performed, and a summary of findings was generated according to Preferred Reporting Items for Systematic Review and Meta‐Analysis (PRISMA) Extension for Scoping Reviews guidelines. Articles were included in the review that involved normal female erectile tissues and radiotherapy side effects. The results show that little scientific investigation into the impacts of radiotherapy on female erectile tissues has been performed. Collaborative scientific investigations by clinical, basic, and behavioral scientists in oncology and radiotherapy are needed to generate radiobiologic and clinical evidence to advance prospective evaluation, prevention, and mitigation strategies that may improve sexual outcomes in female patients.
Abstract ES3-2: Clinical management of moderate penetrance genes
Authors: AW Kurian
Journal: Cancer Research (2022)

Abstract Genetic epidemiologic studies have found that germline pathogenic mutations in the following 12 genes confer a substantial (two-fold or higher) increase in breast cancer risk: ATM, BARD1, BRCA1, BRCA2, CDH1, CHEK2, NF1, PALB2, PTEN, RAD51C, RAD51D and TP53. Mutations in several of these genes, including the notable examples of ATM, CHEK2 and PALB2, are classified as “moderate penetrance”: conferring a relative risk of breast cancer that is between two-times and five-times higher than that of the average woman. Next-generation sequencing technology and lower costs have enabled the widespread use of multiplex germline testing panels that contain both high and moderate penetrance genes. Recent studies have reported a relatively high prevalence of ATM, CHEK2 and PALB2 mutations among unselected breast cancer patients (approximately 0.5-1% per gene), including among women diagnosed at older ages. ATM and CHEK2 mutations are associated with elevated risks of hormone receptor-positive breast cancer, while PALB2 mutations are more associated with triple-negative disease. Important recent developments in the clinical management of patients with moderate penetrance gene mutations include model-based estimates of optimal breast screening protocols; evidence suggesting the safety of adjuvant radiotherapy; emerging data on susceptibility to targeted therapy with poly(ADP-ribose) polymerase inhibitors; and characterization of the risks of developing other, non-breast cancers. Ongoing studies and future research priorities will be discussed. Citation Format: AW Kurian. Clinical management of moderate penetrance genes [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr ES3-2.
HSR22-143: Outcome Differences Amongst Stage-Matched Inflammatory vs Non-Inflammatory Breast Cancer Patients
Authors: Michael Grimm, Kai Johnson, Patrick Schnell, Ashley Pariser, Margaret Gatti-Mays, Jeffrey VanDeusen, Nicole Williams, Daniel Stover, Sagar Sardesai, Robert Wesolowski, Preeti Sudheendra, Bhuvaneswari Ramaswamy, Ko Un Park, Sachin R Jhawar, Amy Kerger, Mathew A Cherian
Journal: Journal of the National Comprehensive Cancer Network (2022)
Efficacy of Tezepelumab in Patients with Severe, Uncontrolled Asthma with Respiratory Comorbidities: Results from the Phase 3 NAVIGATOR Study
Authors: Tara Carr, Jonathan Bernstein, Bill Cook, Gillian Hunter, Chris Ambrose, Jean-Pierre Llanos-Ackert, Andrew Lindsley, Gene Colice
Journal: Journal of Allergy and Clinical Immunology (2022)
CATHETER ABLATION FOR ATRIAL FIBRILLATION IN PATIENTS WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION
Authors: Ahmad Allaw, Hemal M. Nayak, Jia Guo, Andrew D. Beaser, Zaid Aziz, Cevher Ozcan, Gaurav A. Upadhyay
Journal: Journal of the American College of Cardiology (2022)
Medical Documentation Burden Among US Office-Based Physicians in 2019
Authors: Adam Gaffney, Stephanie Woolhandler, Christopher Cai, David Bor, Jessica Himmelstein, Danny McCormick, David U. Himmelstein
Journal: JAMA Internal Medicine (2022)

Many physicians perceive that medical documentation is onerous, detracts from face time with patients, and drives burnout. 1,2 We assessed the burden of medical documentation on US office-based physicians.
Characteristics and outcomes of patients screened for transcatheter mitral valve implantation: <scp>1‐year</scp> results from the <scp>CHOICE‐MI</scp> registry
Authors: Walid Ben Ali, Sebastian Ludwig, Alison Duncan, Jessica Weimann, Georg Nickenig, Tetsu Tanaka, Augustin Coisne, Andre Vincentelli, Raj Makkar, John G. Webb, Mariama Akodad, David W.M. Muller, Fabien Praz, Mirjam G. Wild, Jörg Hausleiter, Sachin S. Goel, Moritz Wyler von Ballmoos, Paolo Denti, Omar Chehab, Simon Redwood, Gry Dahle, Stephan Baldus, Matti Adam, Hendrik Ruge, Rüdiger Lange, Tsuyoshi Kaneko, Lionel Leroux, Nicolas Dumonteil, Didier Tchetche, Hendrik Treede, Michele Flagiello, Jean‐Francois Obadia, Thomas Walther, Maurizio Taramasso, Lars Søndergaard, Sabine Bleiziffer, Tanja K. Rudolph, Neil Fam, Joerg Kempfert, Juan F. Granada, Gilbert H.L. Tang, Ralph Stephan von Bardeleben, Lenard Conradi, Thomas Modine
Journal: European Journal of Heart Failure (2022)
ASSESSING CORONARY PLAQUE CHARACTERISTICS AND DISTRIBUTION ON CT ANGIOGRAPHY IN PATIENTS OF HISPANIC DESCENT
Authors: Jorge Irias Banegas, Hanna Ghanayem, Matthew I. Saleem, Chikvashvili Daniel, Ofek Hai, Roman Zeltser, Amgad N. Makaryus
Journal: Journal of the American College of Cardiology (2022)
OUTCOMES OF HOSPITALIZED PATIENTS WITH ACUTE ISCHEMIC STROKE AND CONCOMITANT NSTEMI - ANALYSIS FROM 2016-2019 NATIONAL INPATIENT SAMPLE
Authors: Soumya Kambalapalli, Nischit Baral, Amith Reddy Seri, Mahin R. Khan, Basel Abdelazeem, Hafiz Khan, Khaing Khaing Htwe, Rohit Rauniyar, Govinda Adhikari, Ashiya Khan, Arvind Kunadi, Hameem U. Changezi, Ahmad Munir
Journal: Journal of the American College of Cardiology (2022)
Interleukin-11 drives human and mouse alcohol-related liver disease
Authors: Maria Effenberger, Anissa A Widjaja, Felix Grabherr, Benedikt Schaefer, Christoph Grander, Lisa Mayr, Julian Schwaerzler, Barbara Enrich, Patrizia Moser, Julia Fink, Alisa Pedrini, Nikolai Jaschke, Alexander Kirchmair, Alexandra Pfister, Bela Hausmann, Reto Bale, Daniel Putzer, Heinz Zoller, Sebastian Schafer, Petra Pjevac, Zlatko Trajanoski, Georg Oberhuber, Timon Adolph, Stuart Cook, Herbert Tilg
Journal: Gut (2022)

Alcoholic hepatitis (AH) reflects acute exacerbation of alcoholic liver disease (ALD) and is a growing healthcare burden worldwide. Interleukin-11 (IL-11) is a profibrotic, proinflammatory cytokine with increasingly recognised toxicities in parenchymal and epithelial cells. We explored IL-11 serum levels and their prognostic value in patients suffering from AH and cirrhosis of various aetiology and experimental ALD.
EASL Clinical Practice Guidelines on prevention and management of bleeding and thrombosis in patients with cirrhosis
Authors: Erica Villa, Marcello Bianchini, Annabel Blasi, Alban Denys, Edoardo G. Giannini, Andrea de Gottardi, Ton Lisman, Emmanuelle de Raucourt, Cristina Ripoll, Pierre-Emmanuel Rautou
Journal: Journal of Hepatology (2022)
Fungal microbiome in inflammatory bowel disease: a critical assessment
Authors: David M. Underhill, Jonathan Braun
Journal: Journal of Clinical Investigation (2022)

The gut microbiome is at the center of inflammatory bowel disease (IBD) pathogenesis and disease activity. While this has mainly been studied in the context of the bacterial microbiome, recent advances have provided tools for the study of host genetics and metagenomics of host-fungal interaction. Through these tools, strong evidence has emerged linking certain fungal taxa, such as Candida and Malassezia, with cellular and molecular pathways of IBD disease biology. Mouse models and human fecal microbial transplant also suggest that some disease-participatory bacteria and fungi may act not via the host directly, but via their fungal-bacterial ecologic interactions. We hope that these insights, and the study design and multi-omics strategies used to develop them, will facilitate the inclusion of the fungal community in basic and translational IBD research.
CLINICAL SIGNIFICANCE OF PERICARDIAL EFFUSION IN PATIENTS HOSPITALIZED WITH IMMUNE CHECKPOINT INHIBITOR ASSOCIATED MYOCARDITIS
Authors: Andrew Hughes, John Power, Olusola A. Orimoloye, Joseph F. Nowatzke, Yuichi Tamura, Mandar Aras, Aarti Asnani, Pierre-Yves Courand, Roberta Florido, Salim Hayek, Vlad Gabriel Zaha, Anita Deswal, Javid Moslehi, Nicolas L. Palaskas
Journal: Journal of the American College of Cardiology (2022)
Imaging and therapeutic targeting of the tumor immune microenvironment with biologics
Authors: Sana Arnouk, Timo W.M. De Groof, Jo A. Van Ginderachter
Journal: Advanced Drug Delivery Reviews (2022)

The important role of tumor microenvironmental elements in determining tumor progression and metastasis has been firmly established. In particular, the presence and activity profile of tumor-infiltrating immune cells may be associated with the outcome of the disease and may predict responsiveness to (immuno)therapy. Indeed, while some immune cell types, such as macrophages, support cancer cell outgrowth and mediate therapy resistance, the presence of activated CD8+ T cells is usually indicative of a better prognosis. It is therefore of the utmost interest to obtain a full picture of the immune infiltrate in tumors, either as a prognostic test, as a way to stratify patients to maximize therapeutic success, or as therapy follow-up. Hence, the non-invasive imaging of these cells is highly warranted, with biologics being prime candidates to achieve this goal.
Analysing foodborne illness outbreak severity in the USA, 2009–19
Authors: Ryan Simpson, Lauren Sallade, Emily Sanchez, Yutong Zhang, Elena Naumova
Journal: The Lancet Global Health (2022)

In the USA, one in six Americans have had a foodborne illness, resulting in approximately US$17·6 billion (2018) of losses annually attributed to medical costs, productivity losses, and economic burden due to death. Previous research has characterised these burdens with use of various methods, including disability-adjusted life-years (DALYs), medical care costs, and revenue losses of food retailers. However, these indices assess only the socioeconomic burdens of outbreaks without providing an index to compare the health-related severity of outbreaks regarding geographical spread of transmission, outbreak duration, and the morbidity and mortality of case outcomes.In this study, we proposed a data-driven index for evaluating outbreak severity using the publicly available US Centers for Disease Control and Prevention's National Outbreak Reporting System (NORS) database from Jan 1, 2009, to Dec 31, 2019. We identified 67 metrics related to the geographical extent (eg, counties or states where individuals with a foodborne illness resided and were exposed), case severity (eg, primary cases, hospital admissions, emergency room visits, and deaths), duration (eg, days of illness and days of exposure events), and their ratios. We selected 11 metrics to create the index on the basis of completeness and distributional characteristics of these metrics. We generated index scores by normalising natural log-transformed values on a 0-1 scale and averaging all metrics per outbreak. Scores ranged from 0 (lowest severity) to 1 (highest severity).NORS reported 9407 outbreaks in our 11-year study period. We found that bacterial outbreaks associated with the genera Streptococcus, Listeria, and Salmonella had the highest median severity scores, whereas Bacillus, Staphylococcus, and Clostridium had the lowest scores. Among protozoa, Cryptosporidium and Cyclospora had the lowest median scores, whereas Giardia and Toxoplasma had the highest scores. Hepatitis had the highest median score for virus-associated outbreaks, whereas Norovirus, which had the most outbreaks reported in our study period (n=3088), had the lowest score.Our index illustrates the usefulness of publicly reported surveillance data in establishing a data-driven approach for monitoring the severity of foodborne outbreaks regarding their spread, duration, and morbidity and mortality. Differences in outbreak severity by pathogen inform how to best allocate resources for monitoring, tracking, and preventing foodborne disease outbreaks. Being data driven, our index emphasises the importance of improved data quality, integrity, and completeness of surveillance records. Future research should strive to validate this index by use of longitudinal cohort studies.US Department of Defense, National Institute of Food and Agriculture.