tbuckley/cabot-search huggingface dataset:
Abstract LB-014: Antibody targeting soluble NKG2D ligand sMIC sensitizes metastatic prostate tumor and other MIC+ tumors to PD1/PD-L1 blockade therapy in pre-clinical models
Authors: Jennifer D. Wu, Jinyu Zhang, Pablo Larrocha, Payal Dhar
Journal: Cancer Research (2019)

Abstract Targeting programmed cell death-1 (PD-1) has produced a survival benefit for patients diagnosed with many types of malignancies. However, the clinical survival benefit in metastatic prostate cancer is only marginal to-date. Currently, the understanding of why metastatic prostate cancer is resistant to PD-1 blockade therapy remains to be defined. Among the many factors that negatively impact response to PD-1 blockade treatment, tumor-derived soluble NKG2D ligands have been reported to hinder the clinical response to immune checkpoint blockade in melanoma patients. Metastatic prostate cancer cells release high levels of the circulating soluble NKG2D ligand, soluble MHC I Chain related molecule (sMIC), a molecule that is absent in classical rodent tumor model. Here, we tested the hypothesis that targeting sMIC sensitizes metastatic prostate tumors to PD-1 blockade therapy. Using a well-described double transgenic TRAMP/MIC mouse model that closely resembles the onco-immune dynamics of human metastatic prostate cancer, we demonstrate that an antibody targeting sMIC significantly enhances the response of prostate tumors to PD-1/PD-L1 blockade therapy. Mechanistically, targeting sMIC enriches NK cell and CD8 T cell infiltration into tumors, equips CD8 T cells with enhanced NKG2D and CD28 dual co-stimulation, and increases the expression of PD-L1+ on prostate tumor cells. Combination of the antibody targeting sMIC and a PD-1/PD-L1 blockade cooperatively augments intra-tumoral NK and antigen-specific CD8 T cell anti-tumor immunity. These findings were validated in syngeneic prostate tumor transplant models and other models of other cancer types. Our pre-clinical study provides proof-of-concept and uncovered novel mechanisms of a viable combination immunotherapy for metastatic prostate cancer and other MIC+ cancers. Citation Format: Jennifer D. Wu, Jinyu Zhang, Pablo Larrocha, Payal Dhar. Antibody targeting soluble NKG2D ligand sMIC sensitizes metastatic prostate tumor and other MIC+ tumors to PD1/PD-L1 blockade therapy in pre-clinical models [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr LB-014.
Comparison of four methods of smoking withdrawal in patients with smoking related diseases. Report by a subcommittee of the Research Committee of the British Thoracic Society.
Journal: BMJ (1983)

Four methods of smoking withdrawal were compared in patients with smoking related diseases attending a hospital or chest clinic. Reinforcing verbal advice with a booklet or with a booklet together with nicotine or placebo chewing gum did not result in greater success than verbal advice alone. Roughly a quarter of those patients who denied smoking had carboxyhaemoglobin and plasma thiocyanate concentrations typical of smokers. At the end of a year 150 out of 1550 patients (9.7%) had successfully stopped smoking.
BBS volume 1 issue 1 Front matter
Authors: Irving Kupfermann, Klaudiusz Weiss, G Hoyle, J Andreae, P Balaban, M Bennett, T Bullock, R Burke, D Chappie, W Davis, W Evoy, J Fentress, C Fowler, M Turvey, P Fraser, S Grillner, A Herman, G Horridge, J Lies, S Kater, B Granzow, F Krasne, W Kristan, J Weeks, J Larimer, E Lewis, R Llinasand, M Bunge, J Lynch, } Mccarthy, D Rosenbaum, P Stein, Y Tsukada, C Wiersma, J Wine, R Zucker, Dalbir Bindra, With Commentary, M Bitterman, A Black, R Bolles, D Booth, A Catania, D Dennett, R Epstein, J Flynn, C Gallistel, R Gilbert, E Hilgard, S Hulse, F Irwin, H Jenkins, H Kendler, P Killeen, M Klingsporn, F Logan, N Mackintosh, J Mazur, E Menzel, O Mowrer, E Murray, D Navarick, J Notterman, K Pribram, J Rosenblatt, T Ryan, K Salzinger, S Soltysik, A Staats, D Stein, R Teevan, E Von Glasersfeld, J Warren, E Wasserman, R Wong, W Wood, Zenon Pylyshyn, M Arbib, M Atherton, L Cohen, S Cushingand, N Hornstein, Z Domotor, H Dreyfus, H Goodluck, L Harmon, J Haugeland, Pvj Hayes, P John Son-Laird, K Leibovic, D Lenat, C Longuet-Higgins, J Mcdermott, A Newell, A Ortony, J Pascual-Leone, R Rodger, R Schank, T Simon, A Sloman, N Sutherland, M Treisman, S Ullman, W Weimer, Y Wilks, P Roland, W Chappie, J Dickinson, J Duysens, G Loeb, P Dyhre-Poulsen, H.-J Freund, G Goodwin, R Granit, P Grigg, A Iannone, J Kelso, M Levitt, B Libet, D Mccloskey, J Millar, G Mpitsos, L Pubols, T Roberts, W Shebilske, G Somjen, K.-H Sontag, J Stein, J Stevens, C Trevarthen, E Walsh, M Wells, M Wiesendanger
Journal: Behavioral and Brain Sciences (1978)

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THE PHARMACOPEIA AND THE PHYSICIAN.CATHARTICS.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ASSOCIATION NEWS.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Night Call
Authors: Bhuvana Chandra
Journal: Annals of Internal Medicine (2001)

Ad Libitum2 January 2001Night CallBhuvana Chandra, MDBhuvana Chandra, MDNorthridge, CA 91326 (Chandra)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-1-200101020-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Time was endless once.The phone shrilled at nightand my life lay before mestretching into infinity.Confidence flowed as a matter of coursein my veins and I'd pick upthe instrument, knowing—unafraidof—what awaitedme at the other end of the line.I never doubted it was the hospital.No matter. I could take careof any emergency, from franticspikes of fever to idiosyncraticreactions to medications.distracts open-eyed ... Author, Article, and Disclosure InformationAffiliations: Northridge, CA 91326 (Chandra)Current Author Address: Bhuvana Chandra, MD, PO Box 7694, Northridge, CA 91327. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 2 January 2001Volume 134, Issue 1Page: 71KeywordsFeversSleepVeins ePublished: 2 January 2001 Issue Published: 2 January 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Rapid fragile X carrier screening and prenatal diagnosis using a nonradioactive PCR test
Authors: W. T. Brown
Journal: JAMA (1993)

<h3>Objective.</h3> —To develop a rapid, nonradioactive test using the polymerase chain reaction (PCR) capable of detecting full fragile X mutations, premutations, and resolving normal alleles and to apply this to prenatal diagnosis and carrier screening of pregnant women at risk for fragile X carrier status. <h3>Design.</h3> —Prenatal and blood sample PCR analysis with confirmation by direct Southern blotting and cytogenetic techniques. <h3>Setting.</h3> —Samples sent to a DNA diagnostic research laboratory at a tertiary referral center. <h3>Participants.</h3> —Pregnant women with a family history of undiagnosed mental retardation or known fragile X syndrome and controls. <h3>Results.</h3> —A rapid, nonradioactive PCR screening protocol for the fragile X mental retardation-1 gene for both normal and mutant alleles was developed. Analysis of 570 control X chromosomes showed a modal number of 30 CGG repeats (range, 12 to 52 repeats) and a calculated heterozygosity of approximately 80%. No excess of homozygosity was found, indicating the test was accurate for normal allele resolution. In addition, 150 unrelated pregnant women were screened. Within known fragile X families, five of 20 pregnant women were diagnosed as carriers. Two new fragile X families were diagnosed among relatives of 130 females with family histories of undiagnosed mental retardation, although no carriers were identified. Prenatal PCR testing of 28 carriers accurately detected nine fetuses with full mutations. <h3>Conclusions.</h3> —This rapid, nonradioactive PCR protocol allows accurate resolution of normal alleles as well as simultaneous detection of carrier alleles and full mutations. With this approach, efficient screening of pregnant women at risk for fragile X carrier status, subsequent genetic counseling of identified carriers, and reliable prenatal diagnosis can be offered. (<i>JAMA</i>. 1993;270:1569-1575)
The Charcoal T, Ratio
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
COMPARISON OF TICAGRELOR VERSUS PRASUGREL FOR INFLAMMATION, VASCULAR FUNCTION AND CIRCULATING ENDOTHELIAL PROGENITOR CELLS IN DIABETIC PATIENTS WITH NON-ST ELEVATION ACUTE CORONARY SYNDROME (NSTE-ACS) REQUIRING CORONARY STENTING: PROSPECTIVE, RANDOMIZED, CROSSOVER TRIAL
Authors: Han Saem Jeong, Soon Jun Hong, Jong-Ho Kim
Journal: Journal of the American College of Cardiology (2018)
The Propaganda for Reform
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Manuscripts Approved for JNCI, June–July 1974
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Manuscripts Approved for JNCI, June–July 1974 Get access JNCI: Journal of the National Cancer Institute, Volume 53, Issue 2, August 1974, Page 598, https://doi.org/10.1093/jnci/53.2.598-c Published: 01 August 1974
BOOK REVIEWS
Authors: E. G. SHAW
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article BOOK REVIEWS Get access Principles and Practice of Radiation Oncology, 2nd Edition Carlos A. Perez , Luther w. Brady , eds. Philadelphia: J. B. Lippincoot, 1992 . EDWARD G. SHAW, M.D. EDWARD G. SHAW, M.D. Division of Radiation Oncology, Mayo Clinic200 First Street, S.W. Rochester, MN 55905 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 16, 19 August 1992, Page 1283, https://doi.org/10.1093/jnci/84.16.1283 Published: 19 August 1992
Are Dust Mite Allergens More Abundant or More Stable Than Other Dermatophagoides Pteronyssinus Proteins?
Authors: Thomas A. Randall, Ryenne N. Ogburn, Yingron Xu, Julia H. Roberts, Marjorie S. Morgan, S Dean Rider, Robert London, Larry G. Arlian, Michael C. Fitzgerald, Geoffrey Mueller, DiAnn L. Vyszenski-Moher
Journal: Journal of Allergy and Clinical Immunology (2016)
Acolo
Authors: M. Therese Southgate
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Omitted Disclosures of Potential Conflicts of Interest
Authors: Robert Schick
Journal: JAMA (2017)

easily place a report in draft status and resume when the clinician responds at his or her convenience.In addition, the electronic health record (EHR) has transformed radiology.When I read a diagnostic study, I quickly scan notes from the emergency department physician, selected consultants, or past admissions.I can see recent laboratory values, pathology results, and all the previous imaging reports.My workflow now includes a step in which within 10 to 60 secondsdepending on case complexity-I have a trove of information to help focus my reporting.Furthermore, I can instantly refresh my knowledge with a quick internet search.When I do connect with a clinician to communicate a result or to clarify an order, the bolus of clinical information from the EHR makes that interaction richer and more efficient for both of us.When I look at the advent of PACS, there is no mourning here.Instead I thank the many engineers who have built these amazing systems of interphysician communication, image sharing, clinical data sharing, and online research.The reports generated in my practice are better than ever and patient care is improved.
Comparative Psychology: A Comprehensive Treatise
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Smoking habits and inflammatory bowel disease: effect on nutrition
Authors: R Butland, Jack Pang, E Gross, A Woodcock, D Geddes
Journal: BMJ (1982)

walks because of the initial training effect.The time chosen to assess exercise tolerance by walking tests is not critical.Shorter times are easier for both patient and investigator and are as reproducible but discriminate slightly less well and have less of a training role.The six-minute walk may represent a sensible compromise.
Formation of Cell Junctions Between Grafted and Host Cardiomyocytes at the Border Zone of Rat Myocardial Infarction
Authors: Tsutomu Matsushita, Masahito Oyamada, Hiroyuki Kurata, Shinsuke Masuda, Akiyuki Takahashi, Takeshi Emmoto, Isao Shiraishi, Yukio Wada, Takahiro Oka, Tetsuro Takamatsu
Journal: Circulation (1999)

Background —Cardiomyocyte transplantation is an innovative strategy for the treatment of heart failure after myocardial infarction. Cell junctions show diverse temporal polarization toward intercalated disks during postnatal development and exhibit altered distribution in diseased hearts. To elucidate the formation of cell junctions between grafted and host cardiomyocytes at the border zone of myocardial infarction, the 3D distribution of cell junctions was examined using immunohistochemistry and confocal microscopy. Methods and Results —Neonatal cardiomyocytes obtained from 3-day-old rats by collagenase digestion and Percoll density centrifugation were injected into the border zones of infarction sites 10 days after coronary ligation in adult rats. At 4 to 14 days after transplantation, hearts were harvested and processed by immunohistochemistry. Antibodies against connexin43, desmoplakin, and cadherin were used to analyze the distribution of gap junctions, desmosomes, and adherens junctions, respectively. Grafted cardiomyocytes were identified by immunohistochemistry for α-smooth muscle actin. Grafted cardiomyocytes tended to align parallel to the host cardiomyocytes. Connexin43, desmoplakin, and cadherin were localized between grafted cardiomyocytes themselves and between grafted and host cardiomyocytes. Semiquantitative analysis revealed that all junctions showed increasing polarization to longitudinal cell termini, especially at the border of grafted and host cardiomyocytes, as time advanced from 4 to 7 days after transplantation. Conclusions —These findings indicate that grafted cardiomyocytes foster electrical pathways with host counterparts through the gap junction and suggest that the environment in infarcted hearts could influence the localization of gap junctions, desmosomes, and adherens junctions.
Medical Education, Registration and Hospital Service
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal