tbuckley/cabot-search huggingface dataset:
Effects of physical training on end-diastolic volume and myocardial performance of isolated rat hearts.
Authors: M MBersohn, JScheuer
Journal: Circulation Research (1977)

We studied the performance of ventricular muscle and cardiac function of hearts from rats conditioned by swimming (CH) and from sedentary rats (SH) in an isolated working heart apparatus modified to measure end-diastolic volume by dye dilution. Instantaneous aortic flow, left ventricular (LV) pressure and oxygen consumption were measured. Heart rate and mean aortic pressure were kept constant, and atrial filling pressure was varied from 5 to 20 cm H2O. Heart weights of SH and CH were equal and end-diastolic pressures and volumes were similar at all atrial pressures. However, ejection fraction, calculated circumferential fiber velocity, peak systolic pressure, peak aortic flow, cardiac output, and stroke work were all greater in CH than in SH, and the differences increased as atrial pressure was increased. Maximal negative dP/dt was greater in CH than SH at all preloads (P less than 0.001). Oxygen consumption of CH was increased in proportion to the increase in work. These results indicate that the improve...
The relative merits of pulsus paradoxus and right ventricular diastolic collapse in the early detection of cardiac tamponade: an experimental echocardiographic study.
Authors: H SKlopfenstein, G HSchuchard, L SWann, T EPalmer, A JHartz, C MGross, SSingh, H LBrooks
Journal: Circulation (1985)

An inspiratory decline in systolic arterial blood pressure exceeding 10 mm Hg has been used clinically to identify hemodynamically significant pericardial effusions. Recently, the echocardiographic sign of right ventricular diastolic collapse (RVDC) has been shown to occur early in the course of cardiac tamponade in association with a hemodynamically important decline in cardiac output. This study was undertaken to compare the relative merits of pulsus paradoxus and the onset of RVDC in the early detection of cardiac tamponade in an unanesthetized canine preparation. We studied six chronically instrumented, conscious dogs with two-dimensional echocardiography during cardiac tamponade induced by continuous infusion of saline into the pericardial space. We recorded intrapericardial pressure, cardiac output (electromagnetic flowmeter), aortic (catheter-tip transducer) and right atrial blood pressures, heart rate, and respiration. None of the dogs had RVDC when the pericardial space was empty, but all dogs sh...
Prostaglandins and renin release: the effect of PGI2, PGE2, and 13,14-dihydro PGE2 on the baroreceptor mechanism of renin release in the dog.
Authors: J GGerber, R TKeller, A SNies
Journal: Circulation Research (1979)

We compared the ability of the vasodilator prostaglandins PGI2, PGE2, and 13,14-dihydro PGE2 to release renin when infused into the denervated, nonfiltering canine kidney in vivo. Papaverine was used as a nonprostaglandin vasodilator. All the prostaglandins tested were capable of stimulating renin secretion, with the scale of potency being 13,14-dihydro PGE2 greater than PGI2 greater than PGE2; papaverine had no effect on renin secretion. These results indicate that both PGE2 and PGI2 can stimulate renin secretion but that vasodilation per se is not a stimulus. 13,14-Dihydro PGE2 was included because it is a poorer substrate than PGE2, both for transport into cells and catabolism to inactive products, but has comparable potency to PGE2 when tested in systems with limited ability to catabolize PGE2. The fact that 13,14-dihydro PGE2 was the most potent prostaglandin tested suggests that the effects of PGE2 in our system are reduced by the kidneys' recognized ability to extract and catabolize PGE2. Since PGI...
Evidence for the presence of calsequestrin in both peripheral and interior regions of sheep Purkinje fibers.
Authors: A OJorgensen, A GMcLeod, K PCampbell, G HDenney
Journal: Circulation Research (1984)

Localization of calsequestrin in sheep Purkinje fibers was determined by indirect immunofluorescence labeling of cryostat sections of sheep myocardium from the intraventricular wall. The results presented show that calsequestrin is present in discrete foci at the peripheral, as well as the interior regions of the cytoplasm. Since Purkinje fibers lack transverse tubules, the presence of calsequestrin at specific foci in the interior regions of the cytoplasm in these cells suggests that calsequestrin is localized in the lumen of peripheral junctional sarcoplasmic reticulum, as well as in the lumen of corbular sarcoplasmic reticulum present in the I band region of the myofibrils. Assuming that the function of calsequestrin is to sequester calcium into the lumen of the sarcoplasmic reticulum, these results imply that two structurally different regions of the sarcoplasmic reticulum function as calcium storage sites in mammalian Purkinje fibers and raises the possibility that calcium storage and/or release from...
The Evolution of Gastroesophagian Varices in Porto-Sinusoidal Vascular Disease (PSVD)
Authors: M Mahmoudi, M Borahma, I Benelbarhdadi, FZ Ajana
Journal: Endoscopy (2021)

Aims Determine the evolution of oesogastric varices and the rate of bleeding recurrence in patients with portal hypertension (PT) by intrahepatic block in PSVD
Coronary risk factors in a community. Findings in Tecumseh, Michigan.
Authors: L DOstrander, D ELamphiear
Journal: Circulation (1976)

In the Tecumseh study population examined from 1967 through 1969, 1457 men and 1607 women were separated into young (20-39 years), middle (40-54 years), and old (past 55 years) age categories. A subset of the study population, 183 men and 200 women who were repeatedly hyperglycemic according to a modified glucose tolerance test, were divided into the same age groups. Means and standard deviations of adiposity index, serum cholesterol, serum triglyceride, blood glucose, and systolic blood pressure were calculated for the total population and hyperglycemics. Correlation coefficients were determined for the relationship between adiposity index and each of the other variables and between paired variables exclusive adiposity index. Correlation coefficients for the latter relationships were recalculated after adjustment for the effect of adiposity. Means of variables were higher in middle and older age categories than in young age categories in both sexes, but the greatest incremental increases occurred between...
Efficacy And Safety Of Full Thickness Resection (FTR) For Colonic Lesions In A Tertiary Care Center
Authors: A Magarotto, F Cavalcoli, A Mancini, E Masci
Journal: Endoscopy (2021)

Aims Aim of this study is to determine the effectiveness and safety of FTR of colic lesions not amenable to resection with traditional techniques or for treating lesions bigger than 2 cm or with a combined endoscopic treatment (EMR and FTR) or with multiple FTR.
Multiomics analysis reveals a distinct response mechanism in multiple primary lung adenocarcinoma after neoadjuvant immunotherapy
Authors: Chao Zhang, Kai Yin, Si-Yang Liu, Li-Xu Yan, Jian Su, Yi-Long Wu, Xu-Chao Zhang, Wen-Zhao Zhong, Xue-Ning Yang
Journal: Journal for ImmunoTherapy of Cancer (2021)

Multiple primary lung cancer (MPLC) remains a tough challenge to diagnose and treat. Although neoadjuvant immunotherapy has shown promising results in early stage non-small cell lung cancer, whether such modality can benefit all primary lesions remains unclear. Herein, we performed integrated multiomics analysis in one patient with early stage MPLC with remarkable tumor shrinkage in a solid nodule and no response in two subsolid nodules after treatment with three cycles of neoadjuvant pembrolizumab. Genomic heterogeneity was observed among responding nodules with high levels of infiltrating CD8 + and CD68 + immune cells. Substantially downregulated human leukocyte antigen (HLA)-related genes and impaired T lymphocyte function were observed in non-responding nodules. A larger proportion of infiltrating tissue resident memory T cells (Trm) along with high T cell receptor repertoire clonality in responding nodules were validated as predictive and prognostic biomarkers in multiple cancer types using external public datasets. These results suggested that neoadjuvant programmed death 1 (PD-1)/programmed death ligand 1 inhibitors alone may not be an optimal therapeutic strategy for MPLC due to disparities in genomic alterations and immune microenvironment among different lesions. Additionally, we postulate that increased infiltration of Trm may be a unique marker of early immune responses to PD-1 blockade.
Short-term vasodilator effect of captopril in patients with severe mitral regurgitation is parasympathetically mediated.
Authors: TWisenbaugh, REssop, PSareli
Journal: Circulation (1991)

BACKGROUNDFew data exist regarding the effects of angiotensin converting enzyme inhibitors in patients with regurgitant valvular lesions. We postulated an immediate improvement in cardiac performance with captopril in mitral regurgitation, which, in a hemodynamically compensated group of patients, might be mediated through parasympathetic vasodilation rather than through blockade of angiotension converting enzyme.METHODS AND RESULTSHemodynamics were examined before and 90 minutes after oral captopril (25-50 mg) in 18 patients (mean age, 31 years) with chronic, severe mitral regurgitation in New York Heart Association functional class II and III. One group of patients was given captopril alone (group 1, n = 9) and a second group was given captopril plus atropine 0.04 mg/kg i.v. (group 2, n = 9). Captopril alone (group 1) produced decreases in heart rate (90-81 beats/min, p less than 0.001), mean arterial pressure (90-73 mm Hg, p less than 0.001), systemic resistance (28-23 Wood units, p = 0.068), and pulmo...
Early afterdepolarizations induced by isoproterenol in patients with congenital long QT syndrome.
Authors: WShimizu, TOhe, TKurita, HTakaki, NAihara, SKamakura, MMatsuhisa, KShimomura
Journal: Circulation (1991)

BACKGROUNDSeveral recent experimental and clinical studies have shown that early afterdepolarizations (EADs) are important in the genesis of QTU prolongation and ventricular tachyarrhythmias (VTs) in patients with long QT syndrome. On the other hand, sympathetic stimulation is well known to contribute to the genesis of QTU prolongation and VTs in patients with congenital long QT syndrome. The present study was performed to examine the influence of isoproterenol on the genesis of EADs and on the action potential durations and QTU intervals in patients with congenital long QT syndrome.METHODS AND RESULTSWe recorded monophasic action potentials (MAPs) with a contact electrode during right atrial pacing at a constant cycle length of 500 msec before and after continuous isoproterenol infusion (1 microgram/min). MAPs were obtained from the right and left ventricular endocardium in six patients with congenital long QT syndrome (LQT group, 18 recording sites) and in eight control patients (control group, 19 recor...
Antipolymer antibodies, silicone breast implants, and fibromyalgia (multiple letters) [9]
Authors: S. A. Edlavitch, S. H. Lamm, M. P. Everson, W D Jr Blackburn, J. H. Korn, M. Angell, S. A. Tenenbaum, J. C. Rice, L. R. Espinoza, R. F. Garry, T. M. Ellis, N. S. Hardt, M. A. Atkinson
Journal: The Lancet (1997)
Oral lipid nanomedicines: Current status and future perspectives in cancer treatment
Authors: Souhaila H. El Moukhtari, Carlos Rodríguez-Nogales, María J. Blanco-Prieto
Journal: Advanced Drug Delivery Reviews (2021)

Oral anticancer drugs have earned a seat at the table, as the need for homecare treatment in oncology has increased. Interest in this field is growing as a result of their proven efficacy, lower costs and positive patient uptake. However, the gastrointestinal barrier is still the main obstacle to surmount in chemotherapeutic oral delivery. Anticancer nanomedicines have been proposed to solve this quandary. Among these, lipid nanoparticles are described to be efficiently absorbed while protecting drugs from early degradation in hostile environments. Their intestinal lymphatic tropism or mucoadhesive/penetrative properties give them unique characteristics for oral administration. Considering that chronic cancer cases are increasing over time, it is important to be able to provide treatments with low toxicity and low prices. The challenges, opportunities and therapeutic perspectives of lipid nanoparticles in this area will be discussed in this review, taking into consideration the pre-clinical and clinical progress made in the last decade.
Long-Term Survival Analysis After Endoscopic Stenting as a Bridge to Surgery for Malignant Colorectal Obstruction: Comparison With Emergency Diverting Colostomy
Authors: R Corsato Scomparin, B Costa Martins, L Lenz, l Haendchen Bento, C Sparapam Marques, A Safatle-Ribeiro, Jr U Ribeiro, S Carlos Nahas, F Maluf-Filho
Journal: Endoscopy (2021)

Aims More than 20 years have elapsed since the first description of the use of Colorectal self-expanding metal stents (SEMS) as bridge therapy of malignant colorectal obstruction, and the theme remains controversial. The aim of this study was to compare the long-term survival of patients with malignant colorectal obstruction with potentially resectable disease who underwent colorectal SEMS versus emergency surgery.
ANGIOKERATOMA CORPORIS DIFFUSUM.
Authors: J. H. PRICE
Journal: British Journal of Dermatology (1955)

Journal Article ANGIOKERATOMA CORPORIS DIFFUSUM. Get access J. H. PRICE, M.B., Ch.B. J. H. PRICE, M.B., Ch.B. The University Department of Surgery, The Royal Infirmary, Manchester Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 67, Issue 3, 1 March 1955, Pages 105–109, https://doi.org/10.1111/j.1365-2133.1955.tb12700.x Published: 01 March 1955
Phorbol ester and dioctanoylglycerol stimulate membrane association of protein kinase C and have a negative inotropic effect mediated by changes in cytosolic Ca2+ in adult rat cardiac myocytes.
Authors: M CCapogrossi, TKaku, C RFilburn, D JPelto, R GHansford, H ASpurgeon, E GLakatta
Journal: Circulation Research (1990)

We used left ventricular myocytes from adult rats to investigate the effect of 4 beta-phorbol 12-myristate 13-acetate (PMA) and of sn-1,2-dioctanoylglycerol (DiC-8) on the membrane association of protein kinase C (PKC), cytosolic [Ca2+], (Cai) homeostasis, and the contractile properties of single cardiac cells. Because PKC activity is known to be highly Ca2+ sensitive, the K+ concentration of the bathing medium was raised from 5 to 30 mM in some experiments, a perturbation known to depolarize the cell and increase Cai. In cell suspensions both PMA (3 x 10(-10) and 3 x 10(-7) M) and DiC-8 (10(-5) and 10(-4) M) increased membrane association of PKC. The effect of PMA (10(-7) M) on PKC translocation was enhanced in 30 mM KCl compared with 5 mM KCl. During steady field stimulation at 1 Hz in 1 mM bathing [Ca2+], both PMA (10(-7) M) and DiC-8 (10(-5) M) decreased twitch amplitude to approximately 60% of control in 5 mM KCl, and the negative inotropic effect of either drug was more pronounced in 30 mM KCl than ...
Colonic Mucosal Pseudolipomatosis
Authors: G Sofianidis, I Moschos, G Tikos, A Paikos, K Evagelopoulos, D Paikos
Journal: Endoscopy (2021)

Aims The presentation of a rare case of mucosal pseudolipomatosis of colon, in order to point out the significance of recognizing this benign condition, during colonoscopy.
Characterization of [3H](+/-)carazolol binding to beta-adrenergic receptors. Application to study of beta-adrenergic receptor subtypes in canine ventricular myocardium and lung.
Authors: A SManalan, H RBesch, A MWatanabe
Journal: Circulation Research (1981)

[3H](+/-)Carazolol, a newly available beta-adrenergic receptor antagonist, can be used to characterize beta-adrenergic receptor subtypes present in membrane vesicles derived from canine ventricular myocardium and canine lung. [3H](+/-)Carazolol binding is saturable, of high affinity, and is displaceable by beta-adrenergic agents in accordance with their known pharmacological potencies. The interaction of carazolol with beta-adrenergic receptors is stereospecific; the (-) stereoisomer demonstrates greater potency than the (+) stereoisomer. Kinetic analysis of [3H](+/-)carazolol interaction with beta-adrenergic receptors suggests that presence of two phases of interaction, consistent with initial rapidly reversible low affinity association of ligand with receptor, followed by isomerization to form a high affinity, slowly reversible complex. Through use of a [3H](+/-)carazolol binding assay based on the high affinity complex, pharmacological specificities of beta-adrenergic receptor populations of canine m...
Cardiovascular status in young patients with insulin-dependent diabetes mellitus.
Authors: T RKimball, S RDaniels, P RKhoury, R AMagnotti, A MTurner, L MDolan
Journal: Circulation (1994)

BACKGROUNDAlthough the existence of diabetic cardiomyopathy in adults is firmly established, the presence of cardiac abnormalities in young diabetic patients is not universally accepted. We sought to determine the early stages of cardiac derangement and whether they are associated with renal dysfunction.METHODS AND RESULTSThirty-nine patients (29 boys; mean age, 17.6 +/- 3.4 years) with insulin-dependent diabetes mellitus underwent echocardiography and timed overnight urine collection. Echocardiographic evaluation consisted of left ventricular mass, performance (shortening fraction, velocity of circumferential fiber shortening, stroke volume, and cardiac index), preload (end-diastolic dimension and volume), after-load (end-systolic wall stress and systemic vascular resistance), and contractility (velocity of fiber shortening relative to wall stress). Creatinine clearance and albumin excretion were measured from the urine sample. Glycosylated hemoglobin levels were measured; height and weight were measured...
Duodenal Diverticulum: A Predictor Of Failure Of Endoscopic Common Bile Duct Stone Extraction?
Authors: A Nakhli, M Sabbah, D Trad, N Bellil, H Elloumi, A Ouakaa, N Bibani, D Gargouri
Journal: Endoscopy (2021)

Aims An intra or para diverticular papilla can be a cause of endoscopic retrograde cholangiopancreatography (ERCP) failure during the treatment of common bile duct (CBD) stones. The objective of this study was to determine the impact of an intra or paradiverticular papilla on the cannulation of the papilla and on the extraction of stones.
Local response to cardiac overload on myosin heavy chain gene expression and isozyme transition.
Authors: SImamura, RMatsuoka, EHiratsuka, MKimura, TNishikawa, ATakao
Journal: Circulation Research (1990)

It is uncertain whether the shift of cardiac myosin heavy chain (MHC) during pressure overload can be induced by some intrinsic factors or by the stress imposed directly on the individual myocytes. To study whether the changes in cardiac MHC gene expression produced by one-sided overload are limited to the involved ventricle or extend to the other ventricle, we examined MHC gene expression and isozyme transition in the left and right ventricles in aortic coarctated and pulmonary artery-banded rats. It has been confirmed that the pressure overload is indeed limited to the loaded ventricle. The results showed that, compared with sham-operated rats, there was no significant induction of the beta-MHC messenger RNA and corresponding protein in the unloaded ventricle, whereas significant induction was observed in the overloaded ventricle. These results demonstrated that the changes in MHC gene expression and isozyme produced by one-sided ventricular overload are limited to the involved ventricle. We conclude th...
Heat-shock protein induction in rat hearts. A direct correlation between the amount of heat-shock protein induced and the degree of myocardial protection.
Authors: M MHutter, R ESievers, VBarbosa, C LWolfe
Journal: Circulation (1994)

BACKGROUNDPrevious studies have demonstrated that heat-shock treatment results in the induction of 72-kD heat-shock protein (HSP72) and a reduction of infarct size after subsequent ischemia and reperfusion.METHODS AND RESULTSTo test the hypothesis that the degree of protection from ischemic injury in heat-shocked rats correlates with the degree of prior HSP72 induction, rats pretreated with 40 degrees C, 41 degrees C, or 42 degrees C of whole-body hyperthermia followed by 24 hours of recovery and control rats (n = 6 in each group) were quantitatively assessed for the presence of myocardial HPS72 by optical densitometry of Western blots and a primary antibody that is specific for HSP72 and a tertiary antibody labeled with 125I. Although rats heat-shocked to 40 degrees C had no significant induction of myocardial HSP72, rats heat-shocked to 41 degrees C and 42 degrees C demonstrated progressively increased amounts of myocardial HSP72 compared with controls. Separate groups of rats heat-shocked to 40 degrees...
Regional perfusion, glucose metabolism, and wall motion in patients with chronic electrocardiographic Q wave infarctions: evidence for persistence of viable tissue in some infarct regions by positron emission tomography.
Authors: RBrunken, JTillisch, MSchwaiger, J SChild, RMarshall, MMandelkern, M EPhelps, H RSchelbert
Journal: Circulation (1986)

Positron-emission tomography with 13N-ammonia and 18F-2-deoxyglucose was used to assess regional perfusion and glucose utilization in 31 chronic electrocardiographic Q wave regions in 20 patients. With previously published criteria, regions of infarction were identified by a concordant reduction in regional perfusion and glucose utilization, and regions of ischemia were identified by preservation of glucose utilization in regions of diminished perfusion. Only 10 of the 31 regions (32%) exhibited myocardial infarction tomographically. In contrast, positron tomography revealed ischemia in six regions (20%) and was normal in 15 regions (48%). Even when Q wave regions were reassigned and consolidated to enhance the specificity of the electrocardiogram, uptake of 18F-2-deoxyglucose was noted in the majority (54%) of the regions. Neither electrocardiographic ST-T changes nor severity of associated wall motion abnormality reliably distinguished tomographically identified regions of ischemia from infarction. Thus...