tbuckley/cabot-search huggingface dataset:
Health‐related quality of life in patients with relapsed/refractory multiple myeloma treated with pomalidomide and dexamethasone ± subcutaneous daratumumab: Patient‐reported outcomes from the APOLLO trial
Authors: Evangelos Terpos, Meletios A. Dimopoulos, Mario Boccadoro, Sosana Delimpasi, Meral Beksac, Eirini Katodritou, Philippe Moreau, Alessandra Pompa, Argiris Symeonidis, Jelena Bila, Albert Oriol, Maria‐Victoria Mateos, Hermann Einsele, Ioannis Orfanidis, Katharine S. Gries, John Fastenau, Kevin Liu, Jianming He, Tobias Kampfenkel, Yanping Qiu, Himal Amin, Robin Carson, Pieter Sonneveld
Journal: American Journal of Hematology (2022)

In the phase 3 APOLLO trial, daratumumab in combination with pomalidomide and dexamethasone (D-Pd) significantly reduced the rate of disease progression or death by 37% relative to Pd alone in patients with relapsed/refractory multiple myeloma (RRMM) who had received ≥1 prior line of therapy including lenalidomide and a proteasome inhibitor. Here, we present patient-reported outcomes (PROs) from APOLLO. Median treatment duration was 11.5 months with D-Pd and 6.6 months with Pd. PRO compliance rates were high and similar in both groups. No changes from baseline were observed for EORTC QLQ-C30 global health status scores in either group, while physical and emotional functioning, disease symptoms, and adverse effects of treatment remained at baseline levels with D-Pd but worsened with Pd. Reductions (p < 0.05) in pain and fatigue were seen at several time points with D-Pd versus Pd. Overall, these results suggest patients' health-related quality of life remained stable when daratumumab was added to Pd, with several results favoring D-Pd versus Pd. These findings complement the significant clinical improvements observed with D-Pd and support its use in patients with RRMM.
Enhancing serious illness communication using artificial intelligence
Authors: Isaac S. Chua, Christine S. Ritchie, David W. Bates
Journal: npj Digital Medicine (2022)

Delivery of serious illness communication (SIC) is necessary to ensure that all seriously ill patients receive goal-concordant care. However, the current SIC delivery process contains barriers that prevent the delivery of timely and effective SIC. In this paper, we describe the current bottlenecks of the traditional SIC workflow and explore how a hybrid artificial intelligence-human workflow may improve the efficiency and effectiveness of SIC delivery in busy practice settings.
OPHTHALMOLOGY AND OTOLOGY.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Salmonella Detectives Report Cases
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GERMANY
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pulmonary Aspects of COVID-19
Authors: Kevin C. Doerschug, Gregory A. Schmidt
Journal: Annual Review of Medicine (2022)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a respiratory virus that gains entry via angiotensin-converting enzyme 2 (ACE2) within airway epithelium. Patients exhibit a spectrum of respiratory symptoms from asymptomatic to respiratory failure. Patient factors including obesity, tobacco use, and black race are all associated with increased ACE2 expression and may contribute to increased complications. Consolidation and ground-glass opacities on chest imaging are typical but not specific for coronavirus disease 2019 (COVID-19). Venous thromboembolism occurs infrequently when prophylactic anticoagulation is provided. However, capillary microthrombosis is nearly ubiquitous, suggesting that it contributes to hypoxemia. Remdesivir and glucocorticoids may benefit some hospitalized patients. Many of those afflicted remain symptomatic two weeks following diagnosis and continue to require health care. Total lung capacity, diffusion capacity, and maximal oxygen consumption may be reduced for months in some survivors. Lung transplant offers chronically critically ill patients new hope, and this option may have increasing potential for outpatients with COVID-19-associated fibrosis.
New Names
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aneuploidy: Cancer's Fatal Flaw?
Authors: Bret R. Williams, Angelika Amon
Journal: Cancer Research (2009)

Abstract Aneuploidy is a characteristic of cancer, with greater than 90% of all solid tumors in humans carrying an aberrant karyotype. Yet, whether or how this condition contributes to tumorigenesis is not understood. Here we summarize our recent findings on the effects of aneuploidy on cell physiology and proliferation. These studies suggest that aneuploidy puts significant stress on the cell, which responds to this condition in what can be viewed as an aneuploidy stress response. We will discuss how our results may bear on our understanding of the role of this condition in tumorigenesis and how they may provide new opportunities for treatment of the disease. [Cancer Res 2009;69(13):5289–91]
RELATION OF LEFT VENTRICULAR REMODELING TO LEFT VENTRICULAR SYSTOLIC FUNCTION MEASURES AT MIDDLE AGE: CORONARY ARTERY RISK DEVELOPMENT IN YOUNG ADULTS (CARDIA) STUDY
Authors: Satoru Kishi, Jared Reis, Bharath A. Venkatesh, Yoshiaki Ohyama, Donald Lloyd-Jones, Cora Lewis, Stephen Sidney, Pamela Schreiner, Kiang Liu, Samuel Gidding, Akihiro Isogawa, Joao Lima
Journal: Journal of the American College of Cardiology (2017)
Epigenetic and Transcriptional Dysregulation in T cells of Patients with Atopic Dermatitis
Authors: Amy Eapen, Leah Kottyan, Sreeja Parameswaran, Carmy Forney, Lee Edsall, Daniel Miller, Omer Donmez, Matthew Weirauch, Katelyn Dunn, Xiaoming Lu, Marissa Granitto, Hope Rowden, Adam Magier, Mario Pujato, Xiaoting Chen, David Bernstein, Ashley Devonshire, Marc Rothenberg
Journal: Journal of Allergy and Clinical Immunology (2022)
Eating disorders in pregnancy
Authors: M Kníže, Z Baraníková, V Krejčová, T Fait
Journal: BMJ (2008)

To highlight a problem of eating disorders in pregnancy and the need for interdisciplinary cooperation in these cases.Case report.Department of Gynecology and Obstetrics, 2nd Faculty of Medicine, University hospital Motol, Prague.We report the course of pregnancy in a 19-year-old woman with an atypical form of mental anorexia. The patient was repeatedly hospitalized for metabolic disruption. The pregnancy was finally terminated at the 27th week of pregnancy for fetal growth restriction of the fetus.Despite the frequent irregularities of the menstrual cycle in eating disorders, a spontaneous conception is possible. The prognosis of pregnancy is uncertain and may endanger the mother and fetus. Management of pregnant women with eating disorders requires the cooperation of a perinatologist, internist, nutritional therapist, psychiatrist or psychologist.
Fully automated volumetric measurement of malignant pleural mesothelioma by deep learning AI: validation and comparison with modified RECIST response criteria
Authors: Andrew C Kidd, Owen Anderson, Gordon W Cowell, Alexander J Weir, Jeremy P Voisey, Matthew Evison, Selina Tsim, Keith A Goatman, Kevin G Blyth
Journal: Thorax (2022)

Background In malignant pleural mesothelioma (MPM), complex tumour morphology results in inconsistent radiological response assessment. Promising volumetric methods require automation to be practical. We developed a fully automated Convolutional Neural Network (CNN) for this purpose, performed blinded validation and compared CNN and human response classification and survival prediction in patients treated with chemotherapy. Methods In a multicentre retrospective cohort study; 183 CT datasets were split into training and internal validation (123 datasets (80 fully annotated); 108 patients; 1 centre) and external validation (60 datasets (all fully annotated); 30 patients; 3 centres). Detailed manual annotations were used to train the CNN, which used two-dimensional U-Net architecture. CNN performance was evaluated using correlation, Bland-Altman and Dice agreement. Volumetric response/progression were defined as ≤30%/≥20% change and compared with modified Response Evaluation Criteria In Solid Tumours (mRECIST) by Cohen’s kappa. Survival was assessed using Kaplan-Meier methodology. Results Human and artificial intelligence (AI) volumes were strongly correlated (validation set r=0.851, p&lt;0.0001). Agreement was strong (validation set mean bias +31 cm 3 (p=0.182), 95% limits 345 to +407 cm 3 ). Infrequent AI segmentation errors (4/60 validation cases) were associated with fissural tumour, contralateral pleural thickening and adjacent atelectasis. Human and AI volumetric responses agreed in 20/30 (67%) validation cases κ=0.439 (0.178 to 0.700). AI and mRECIST agreed in 16/30 (55%) validation cases κ=0.284 (0.026 to 0.543). Higher baseline tumour volume was associated with shorter survival. Conclusion We have developed and validated the first fully automated CNN for volumetric MPM segmentation. CNN performance may be further improved by enriching future training sets with morphologically challenging features. Volumetric response thresholds require further calibration in future studies.
The impact of brain invasion criteria on the incidence and distribution of WHO grade 1, 2, and 3 meningiomas
Authors: Alexander D Rebchuk, Bradley M Chaharyn, Armaghan Alam, Celine D Hounjet, Peter A Gooderham, Stephen Yip, Serge Makarenko
Journal: Neuro-Oncology (2022)

In 2016 brain invasion was added as a standalone diagnostic criterion for Grade 2 meningiomas in the WHO Classification of Brain Tumors. The aim of this study was to compare the incidence and distribution of meningiomas, and agreement, between the 2007 and 2016 WHO criteria.
Proactive vs Reactive Machine Learning in Health Care
Authors: Yuan Luo, Richard G. Wunderink, Donald Lloyd-Jones
Journal: JAMA (2022)

Baptiste Vasey, MMed; Stephan Ursprung, MMed; Benjamin Beddoe, BSc; Elliott H. Taylor, BSc; Neale Marlow, MBBS; Nicole Bilbro, MD; Peter Watkinson, MD; Peter McCulloch, MD
Preoperative and Postoperative Approaches to Gastroesophageal Cancer: What is All the Fuss About
Authors: Lucy X. Ma, Elan D. Panov, Michael J. Allen, Gail E. Darling, Jonathan C. Yeung, Carol J. Swallow, Savtaj S. Brar, Rebecca K. Wong, Patrick Veit-Haibach, Sangeetha N. Kalimuthu, Eric X. Chen, Raymond W. Jang, Elena Elimova
Journal: Journal of the National Comprehensive Cancer Network (2022)

Gastroesophageal cancers carry poor prognoses, and are a leading cause of cancer-related morbidity and mortality worldwide. Even in those with resectable disease, more than half of patients treated with surgery alone experience disease recurrence. Multimodality approaches using preoperative and postoperative chemotherapy and/or radiotherapy have been established, resulting in incremental improvements in outcomes. Globally, there is no standardized approach, and treatment varies with geographic location. The question remains of how to select the optimal perioperative treatment that will maximize benefit for patients while avoiding toxicities from unnecessary therapies. This article reviews currently available evidence supporting preoperative and postoperative therapy in gastroesophageal cancers, with an emphasis on recent practice-changing trials and ongoing areas of investigation, including the role of immune checkpoint inhibition and biomarker-guided treatment.
KIR2DS1–HLA-C status as a predictive marker for benefit from rituximab: a post-hoc analysis of the RICOVER-60 and CLL8 trials
Authors: Dominic Kaddu-Mulindwa, Bettina Altmann, Sandra Robrecht, Marita Ziepert, Evi Regitz, Eugen Tausch, Gerhard Held, Viola Poeschel, Vadim Lesan, Joerg Thomas Bittenbring, Lorenz Thurner, Michael Pfreundschuh, Konstantinos Christofyllakis, Lorenz Truemper, Markus Loeffler, Norbert Schmitz, Markus Hoth, Michael Hallek, Kirsten Fischer, Stephan Stilgenbauer, Moritz Bewarder, Torben Millard Rixecker
Journal: The Lancet Haematology (2022)
Immunological mechanisms involved in dog dander allergoid response
Authors: David Calzada, Tamara Aranda, Marta Escutia, Dolors Balsa, Francisca Alvarez, Cristobalina Mayorga, María Salas, Maria Antonia Odena, Eliandre Oliveira, Mariona Pascal
Journal: Journal of Allergy and Clinical Immunology (2022)
County-Level Variation in Cirrhosis-Related Mortality in the US, 1999-2019
Authors: Audrey Y. Ha, Michael H. Le, Linda Henry, Yee Hui Yeo, Ramsey C. Cheung, Mindie H. Nguyen
Journal: JAMA Network Open (2022)

This cross-sectional study characterizes cirrhosis mortality by metropolitan categories and potential disparities among the various rural and urban demographic subgroups using the US Centers for Disease Control and Prevention WONDER database.
Comparative Genomics Elucidates the Origin of a Supergene Controlling Floral Heteromorphism
Authors: Giacomo Potente, Étienne Léveillé-Bourret, Narjes Yousefi, Rimjhim Roy Choudhury, Barbara Keller, Seydina Issa Diop, Daniël Duijsings, Walter Pirovano, Michael Lenhard, Péter Szövényi, Elena Conti
Journal: Molecular Biology and Evolution (2022)

Abstract Supergenes are nonrecombining genomic regions ensuring the coinheritance of multiple, coadapted genes. Despite the importance of supergenes in adaptation, little is known on how they originate. A classic example of supergene is the S locus controlling heterostyly, a floral heteromorphism occurring in 28 angiosperm families. In Primula, heterostyly is characterized by the cooccurrence of two complementary, self-incompatible floral morphs and is controlled by five genes clustered in the hemizygous, ca. 300-kb S locus. Here, we present the first chromosome-scale genome assembly of any heterostylous species, that of Primula veris (cowslip). By leveraging the high contiguity of the P. veris assembly and comparative genomic analyses, we demonstrated that the S-locus evolved via multiple, asynchronous gene duplications and independent gene translocations. Furthermore, we discovered a new whole-genome duplication in Ericales that is specific to the Primula lineage. We also propose a mechanism for the origin of S-locus hemizygosity via nonhomologous recombination involving the newly discovered two pairs of CFB genes flanking the S locus. Finally, we detected only weak signatures of degeneration in the S locus, as predicted for hemizygous supergenes. The present study provides a useful resource for future research addressing key questions on the evolution of supergenes in general and the S locus in particular: How do supergenes arise? What is the role of genome architecture in the evolution of complex adaptations? Is the molecular architecture of heterostyly supergenes across angiosperms similar to that of Primula?
Clinical Phenotypes of Cystic Fibrosis Carriers
Authors: Philip M. Polgreen, Alejandro P. Comellas
Journal: Annual Review of Medicine (2022)

Cystic fibrosis (CF) is an autosomal recessive genetic disorder caused by mutations in CFTR, the cystic fibrosis transmembrane conductance regulator gene. People with CF experience a wide variety of medical conditions that affect the pulmonary, endocrine, gastrointestinal, pancreatic, biliary, and reproductive systems. Traditionally, CF carriers, with one defective copy of CFTR, were not thought to be at risk for CF-associated diseases. However, an emerging body of literature suggests that heterozygotes are at increased risk for many of the same conditions as homozygotes. For example, heterozygotes appear to be at increased risk for chronic pancreatitis, atypical mycobacterial infections, and bronchiectasis. In the United States alone, there are almost 10 million CF carriers. Universal newborn screening and prenatal genetic screening will identify more. Thus, there is a critical need to develop more precise estimates of health risks attributable to the CF carrier state across the lifespan.
The “funitel” technique for endoscopic target biopsy at a biliary bifurcation
Authors: Tsuyoshi Hamada, Tomotaka Saito, Kensaku Noguchi, Yousuke Nakai, Mitsuhiro Fujishiro
Journal: Endoscopy (2022)

Endoscopic retrograde cholangiopancreatography (ERCP) with biopsy is a gold-standard procedure for pathological assessment of spreading of cholangiocarcinoma [1] [2]. Tumor existence at landmark biliary bifurcations should be assessed to consider the indication and extent of surgical resection. However, technical difficulties in pushing biopsy forceps against a biliary bifurcation may inhibit precise target biopsy. Here, we present a simple modification of widely used biopsy forceps for highly selective biopsy at the bifurcation of bile ducts at segments II and III (B2 and B3) ([Video 1]).
Reflections on the Doctor's Anguish
Authors: Miles J. Edwards
Journal: Annals of Internal Medicine (1993)

Letters1 January 1993Reflections on the Doctor's AnguishMiles J. Edwards, MD and Susan W. Tolle, MDMiles J. Edwards, MDCenter for Ethics in Health Care; Oregon Health Sciences University; Portland, OR 97201Search for more papers by this author and Susan W. Tolle, MDCenter for Ethics in Health Care; Oregon Health Sciences University; Portland, OR 97201Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-1-199301010-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Weinryb is absolutely correct. A competent patient's wishes to refuse life-sustaining treatment should be respected, even if family members object. Because survivors usually benefit so much from coming to peace with their loved one's decision [1], we encourage and facilitate open communication with family members. In “Mr. Larsen's” case, he understood the potential benefit to his family and agreed to the delay needed to reach consensus.Dr. Baker and colleagues suggest that in New Zealand a hospital ethics committee should approve the disconnection of the ventilator in a case like the one we described. In the United ...References1. Tolle SW, Bascom PB, Hickam DH, Benson JA Jr. Communication between physicians and surviving spouses following patient deaths. J Gen Intern Med. 1986; 1:309-14. Google Scholar2. Ethics Manual. Third edition. Philadelphia: American College of Physicians Ann Intern Med. 1992; 117:947-60. Google Scholar Author, Article, and Disclosure InformationAffiliations: Center for Ethics in Health Care; Oregon Health Sciences University; Portland, OR 97201 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1993Volume 118, Issue 1Page: 78-80KeywordsEnd of life careFearNursesPatient advocacyPatientsQuality of lifeSedationVentilators ePublished: 15 August 2000 Issue Published: 1 January 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Assessment of Tumor Redox Status through (<i>S</i>)-4-(3-[18F]fluoropropyl)-<scp>L</scp>-Glutamic Acid PET Imaging of System xc− Activity
Authors: Patrick N. McCormick, Hannah E. Greenwood, Matthias Glaser, Oliver D.K. Maddocks, Thibault Gendron, Kerstin Sander, Gayatri Gowrishankar, Aileen Hoehne, Tong Zhang, Adam J. Shuhendler, David Y. Lewis, Mathias Berndt, Norman Koglin, Mark F. Lythgoe, Sanjiv S. Gambhir, Erik Årstad, Timothy H. Witney
Journal: Cancer Research (2018)

The cell's endogenous antioxidant system is vital to maintenance of redox homeostasis. Despite its central role in normal and pathophysiology, no noninvasive tools exist to measure this system in patients. The cystine/glutamate antiporter system x