tbuckley/cabot-search huggingface dataset:
A novel application of the transnasal gastroscope for endoscopic imaging of the appendiceal lumen
Authors: Binglan Zhang, Xuchun Zhou, Fang Tan, Bingqiang Zhang
Journal: Endoscopy (2021)

A 59-year-old man was admitted with a 1-year history of recurrent diarrhea and abdominal pain. Colonoscopy performed the previous year showed multiple colonic ulcers, which were confirmed by pathology. Repeat colonoscopy demonstrated a sigmoid ulcer with stenosis that could not be traversed with an adult colonoscope.
1175P Predictors of pneumonitis in locally advanced non-small cell lung cancer patients treated on the Pacific regimen
Authors: R.W. Gao, P. Prodduturvar, C.N. Day, W.S. Harmsen, K.R. Olivier, K.W. Merrell, Y.I. Garces, S. James, T.K. McKone, L. Ng, R.S. Smith, A. Stockham, Z. Wilson, J.R. Molina, K. Leventakos, A. Dimou, A.S. Mansfield, A.C. Amundson, D. Owen
Journal: Annals of Oncology (2021)
481P Evaluation of serum mid-infrared spectroscopy as new prognostic marker for bevacizumab-based chemotherapy in first-line treatment of metastatic colorectal cancer
Authors: R. Chautard, J. Léger, O. Bouche, C. Borg, J-Y. Douillard, S. Manfredi, E. Terrebonne, O. Capitain, J-P. Spano, M. Caulet, W. Raoul, M. Guéguinou, O. Hérault, A. Ferru, C.J. Pobel, O. Sire, T. Lecomte
Journal: Annals of Oncology (2021)
Self‐Healing of Hyaluronic Acid to Improve In Vivo Retention and Function
Authors: Anna Gilpin, Yuze Zeng, Jiaul Hoque, Ji Hyun Ryu, Yong Yang, Stefan Zauscher, William Eward, Shyni Varghese
Journal: Advanced Healthcare Materials (2021)

Abstract Convergent advances in the field of soft matter, macromolecular chemistry, and engineering have led to the development of biomaterials that possess autonomous, adaptive, and self‐healing characteristics similar to living systems. These rationally designed biomaterials can surpass the capabilities of their parent material. Herein, the modification of hyaluronic acid (HA) to exhibit self‐healing properties is described, and its physical and biological function both in vitro and in vivo is studied. The in vitro findings showed that self‐healing HA designed to undergo self‐repair improves lubrication, enhances free radical scavenging, and attenuates enzymatic degradation compared to unmodified HA. Longitudinal imaging following intraarticular injection of self‐healing HA shows improved in vivo retention despite its low molecular weight. Concomitant with these functions, intraarticular injection of self‐healing HA mitigates anterior cruciate ligament injury‐mediated cartilage degeneration in rodents. This proof‐of‐concept study shows how incorporation of functional properties such as self‐healing can be used to surpass the existing capabilities of biolubricants.
201TiP Evaluation of the feasibility of ultrasound-guided clipping of suspicious intramammary lesions in primary breast cancer patients receiving neoadjuvant therapy (Ultra3Detect)
Authors: E. Vlachou, S. Kümmel, N. Künzel, E. Breit, D. Schindowski, K. Pankert, S. Hentsch, V. Hanf, D. Weber, S-T. Graßhoff, C. Müller, W. Lucke, P. Deuschle, K. Engellandt, A. Rüland, P. Dall, H. Harrach, S. Bruzas, O. Chiari, M. Reinisch
Journal: Annals of Oncology (2021)
Gender-equitable caregiver attitudes and education and safety of adolescent girls in South Kivu, DRC: A secondary analysis from a randomized controlled trial
Authors: Ilana Seff, Kathryn Falb, Gary Yu, Debbie Landis, Lindsay Stark
Journal: PLoS Medicine (2021)

Adolescent girls face myriad threats to their well-being and safety as a result of gender-inequitable attitudes and norms, and these risks are often exacerbated during humanitarian emergencies. While humanitarian actors have begun to address caregivers' behaviors and gender attitudes as an approach to support and meet the needs of adolescent girls, best practices for working with caregivers to improve adolescent girls' well-being in these settings have yet to be identified.This study uses panel data from a program evaluation to analyze associations between changes in gender-equitable attitudes among caregivers and changes in schooling and violence victimization for girls ages 10 to 14 years old in the Democratic Republic of the Congo (DRC). Participants were recruited in May 2015 for baseline (May to July 2015) and endline (August to October 2016) data collection. Baseline and endline data for both caregivers and girls were available for 732 girls. The average ages of adolescents and caregivers were 12 and 40.7, respectively, and 92% of caregivers were female. The predictor of interest was the change in caregivers' gender-equitable attitudes between the 2 points in time, where attitudes were measured using 10 underlying survey questions. The primary outcomes of interest were dichotomous and included improvement in schooling participation and declines in physical, sexual, and emotional violence and feeling uncared for. Logistic regression was used to estimate the association between changes in caregivers' attitudes and 5 outcomes of interest and revealed that an increase in a caregiver's gender-equitable attitude score was associated with significantly greater odds of a girl experiencing an improvement in schooling participation (aOR = 1.08, CI [1.005, 1.154], p = 0.036) and of a girl experiencing a marginal decline in physical violence victimization (aOR = 1.07, CI [0.989, 1.158], p = 0.092). Analyses also revealed that older girls had lower odds of experiencing an improvement in schooling participation (aOR = 0.77, CI [0.686, 0.861], p < 0.001), physical violence (aOR = 0.86, CI [0.757, 0.984], p = 0.028), sexual violence (aOR = 0.86, CI [0.743, 1.003], p = 0.055), or emotional violence (aOR = 0.98, CI [0.849, 1.105], p = 0.005). Important limitations in this study include the self-reported nature of outcomes, use of single questionnaire items to construct the outcome variables, and potential self-selection bias.Results suggest that supporting caregivers to increase gender equitable attitudes may be associated with benefits in dual outcomes of education and safety for adolescent girls in eastern DRC. Further research is needed to better understand how to induce a shift in these attitudes in multisectoral programming.NCT02384642.
Progress without exclusion in the search for an evolutionary basis of music
Authors: Daniel L Bowling, Marisa Hoeschele, Jacob C Dunn
Journal: Behavioral and Brain Sciences (2021)

Abstract Mehr et al.'s hypothesis that the origins of music lie in credible signaling emerges here as a strong contender to explain early adaptive functions of music. Its integration with evolutionary biology and its specificity mark important contributions. However, much of the paper is dedicated to the exclusion of popular alternative hypotheses, which we argue is unjustified and premature.
1376O The effect of hyperthermic intraperitoneal chemotherapy (HIPEC) upon cytoreductive surgery (CRS) in gastric cancer (GC) with synchronous peritoneal metastasis (PM): A randomized multicentre phase III trial (GASTRIPEC-I-trial)
Authors: B. Rau, H. Lang, A. Königsrainer, I. Gockel, H-G. Rau, H. Seeliger, C. Lerchenmüller, D. Reim, R. Wahba, M. Angele, S. Heeg, T. Keck, A. Weimann, S. Topp, P. Piso, A. Brandl, E. Trips, V. Heinemann, P.C. Thuss-Patience
Journal: Annals of Oncology (2021)
Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication
Authors: Junjun Chu, Changsheng Xing, Yang Du, Tianhao Duan, Siyao Liu, Pengfei Zhang, Chumeng Cheng, Jill Henley, Xin Liu, Chen Qian, Bingnan Yin, Helen Yicheng Wang, Rong-Fu Wang
Journal: Nature Metabolism (2021)

Caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19 is a virus-induced inflammatory disease of the airways and lungs that leads to severe multi-organ damage and death. Here we show that cellular lipid synthesis is required for SARS-CoV-2 replication and offers an opportunity for pharmacological intervention. Screening a short-hairpin RNA sublibrary that targets metabolic genes, we identified genes that either inhibit or promote SARS-CoV-2 viral infection, including two key candidate genes, ACACA and FASN, which operate in the same lipid synthesis pathway. We further screened and identified several potent inhibitors of fatty acid synthase (encoded by FASN), including the US Food and Drug Administration-approved anti-obesity drug orlistat, and found that it inhibits in vitro replication of SARS-CoV-2 variants, including more contagious new variants, such as Delta. In a mouse model of SARS-CoV-2 infection (K18-hACE2 transgenic mice), injections of orlistat resulted in lower SARS-CoV-2 viral levels in the lung, reduced lung pathology and increased mouse survival. Our findings identify fatty acid synthase inhibitors as drug candidates for the prevention and treatment of COVID-19 by inhibiting SARS-CoV-2 replication. Clinical trials are needed to evaluate the efficacy of repurposing fatty acid synthase inhibitors for severe COVID-19 in humans. Pharmacological inhibitors of fatty acid synthase, including the approved anti-obesity drug orlistat, are shown to inhibit replication of SARS-CoV-2 in vitro and in a mouse model of infection in vivo.
Abstract 8905: Protein Kinase G Positively Regulates Proteasome Proteolytic Function in the Heart
Authors: Mark J Ranek, Curtis Kost, Douglas S Martin, Xuejun Wang
Journal: Circulation (2012)

The Ubiquitin Proteasome System (UPS) plays a pivotal role in the intracellular protein homeostasis, thereby regulating a variety of cellular processes including protein quality control (PQC). Inadequate PQC and proteasome functional insufficiency are associated with and may play an important role in adverse cardiac remodeling and cardiac failure (CHF). This is best reflected by the increased presence of misfolded proteins and protein aggregates in failing human hearts. While the regulatory mechanisms of these processes remain poorly understood they carry significant clinical implications. Reduced protein kinase G (PKG) activity is well documented in CHF. Increasing the activity PKG, during various cardiovascular diseases improves patient prognosis. We hypothesize that PKG plays a role in regulating UPS function. Using both genetic and/or pharmacological manipulation of PKG activity in cultured cardiomyocytes and intact mice and taking advantage of a previously validated surrogate misfolded protein (GFPu or GFPdgn) as well as a bona fide misfolded protein (R120G-CryAB) that is known to cause proteinopathy in human and mice, our studies have revealed a significant role for PKG in UPS regulation. In cultured cardiomyocytes, PKG inhibition was achieved by PKG-specific siRNA transfection or administration of PKG pharmacological inhibitor while PKG activity was induced by adenoviral delivery of a constitutively active PKG or by the treatment of phosphodiesterase 5A inhibitor Sildenafil. PKG activation significantly stimulated UPS activity in cultured cardiomyocytes as indicated by a reduced protein level of GFPu and increased proteasome activities; while PKG inhibition reduced UPS proteolytic activity. Furthermore PKG activation resulted in enhanced removal of R120G-CryAB. These findings from cell culture studies were further corroborated by in vivo findings from manipulating the muscarinic (M) receptor in GFPdgn transgenic mice. The M receptor signals through PKG. Activating the M receptor deceased, while antagonizing the M receptor increased, the steady protein level of GFPdgn in the heart. Hence, we conclude that PKG positively regulates the UPS thereby supporting cardiomyocyte PQC.
神経筋接合部形成のためのプラットホームとしてのRapsn相分離による膜なし凝縮【JST・京大機械翻訳】
Authors: Xing Guanglin, Jing Hongyang, Yu Zheng, Chen Peng, Wang Hongsheng, Xiong Wen-Cheng, Mei Lin
Journal: Neuron (2021)
Why language survives as the dominant communication tool: A neurocognitive perspective
Authors: Qing Zhang, Edward Ruoyang Shi
Journal: Behavioral and Brain Sciences (2021)

Abstract By focusing on the contributions of subcortical structures, our commentary suggests that the functions of the hippocampus underlying “displacement,” a feature enabling humans to communicate things and situations that are remote in space and time, make language more effective at social bonding. Based on the functions of the basal ganglia and hippocampus, evolutionary trajectory of the subcomponents of music and language in different species will also be discussed.
The BMJ Awards 2021: “Landmark” study on dexamethasone wins paper of the year
Authors: Matthew Limb
Journal: BMJ (2021)

Researchers whose rapid investigations into possible covid treatments that helped to save over a million lives worldwide have won a top prize in this year’s BMJ Awards.

The Recovery collaborative group’s trial, which was the first to show that the inexpensive steroid dexamethasone improved survival among patients with covid-19 who had severe respiratory complications, was awarded The BMJ ’s research paper of the year.1 It found that dexamethasone reduced the risk of death by a third among patients on ventilators and by almost a fifth among those on oxygen.

The award judges praised the “landmark” NHS study. They said, “The setup of …
<i>Notes from the Field:</i> Deaths Related to Hurricane Ida Reported by Media — Nine States, August 29–September 9, 2021
Authors: Arianna Hanchey, Amy Schnall, Tesfaye Bayleyegn, Sumera Jiva, Anna Khan, Vivi Siegel, Renée Funk, Erik Svendsen
Journal: MMWR Morbidity and Mortality Weekly Report (2021)

On August 29, 2021, Hurricane Ida made landfall near Port Fourchon, Louisiana, as a Category 4 hurricane with sustained winds of 150 mph, causing life-threatening storm surges, wind damage, heavy rainfall, and power outages that affected approximately one million homes and businesses along the U.S. Gulf Coast (1,2).The storm then traveled Northeast as a tropical depression, causing flash flooding, tornadoes, and power outages, before exiting offshore.*During Hurricane Ida's widespread geographic impact, collection and analysis of timely data were necessary to understand regional differences, such as causes and circumstances of death, and to guide public health messaging to promote action (3).In response to the disaster, CDC's Epidemiology Surveillance Task Force † (Epi/Surv Task Force) activated media mortality surveillance to track online reports of deaths related to Hurricane Ida using standardized key search terms from an internal standard operating procedure that outlines surveillance protocol.Team members compiled and coded the information from identified sources (e.g., news media articles, press releases, and social media posts) into a database, analyzed the compiled data, and shared results with emergency response leadership and health communicators to provide situational awareness and guide messaging.§ As of September 9, 2021, the media reported 91 deaths caused by Hurricane Ida across nine states, 56 (61.5%) of which occurred in the Northeast (Table ).Among 71 (78.0%) decedents with known age, 29 (40.8%) were aged ≥65 years.By cause of death, the majority of deaths (55; 60.4%) occurred by drowning, most (52; 94.5%) of which occurred in the Northeast.Four reported deaths (4.4%) were work-related, either associated with the emergency response (three) or workplace (one).The top three circumstances of death were drowning (34; 37.4%), vehicular (22; 24.2%), and generator-or power outage-related (17; 18.7%).Cause of death is defined as the specific injury or condition that leads to death; circumstance of death is the determination of how the specific injury or condition leads to death.Among the vehicular deaths, 20 (90.9%) were drownings
1834P Impact of comprehensive genomic profiling and molecular tumor board decision on clinical outcome of patients with solid tumors: A single center, retrospective analysis
Authors: S.V. Ludwig, L. Schmid, A. Kahraman, M. Rechsteiner, M. Zoche, A. Curioni-Fontecedro, A.R. Siebenhüner, K.J. Dedes, M. Kiessling, R. Fritsch, A. Wicki, H. Moch, A. Weber, C. Britschgi
Journal: Annals of Oncology (2021)
SARS-CoV-2 immune repertoire in MIS-C and pediatric COVID-19
Authors: Supriya Ravichandran, Juanjie Tang, Gabrielle Grubbs, Youri Lee, Sara Pourhashemi, Laila Hussaini, Stacey A. Lapp, Robert C. Jerris, Vidisha Singh, Ann Chahroudi, Evan J. Anderson, Christina A. Rostad, Surender Khurana
Journal: Nature Immunology (2021)

There is limited understanding of the viral antibody fingerprint following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children. Herein, SARS-CoV-2 proteome-wide immunoprofiling of children with mild/moderate or severe coronavirus disease 2019 (COVID-19) versus multisystem inflammatory syndrome in children versus hospitalized control patients revealed differential cytokine responses, IgM/IgG/IgA epitope diversity, antibody binding and avidity. Apart from spike and nucleocapsid, IgG/IgA recognized epitopes in nonstructural protein (NSP) 2, NSP3, NSP12–NSP14 and open reading frame (ORF) 3a–ORF9. Peptides representing epitopes in NSP12, ORF3a and ORF8 demonstrated SARS-CoV-2 serodiagnosis. Antibody-binding kinetics with 24 SARS-CoV-2 proteins revealed antibody parameters that distinguish children with mild/moderate versus severe COVID-19 or multisystem inflammatory syndrome in children. Antibody avidity to prefusion spike correlated with decreased illness severity and served as a clinical disease indicator. The fusion peptide and heptad repeat 2 region induced SARS-CoV-2-neutralizing antibodies in rabbits. Thus, we identified SARS-CoV-2 antibody signatures in children associated with disease severity and delineate promising serodiagnostic and virus neutralization targets. These findings might guide the design of serodiagnostic assays, prognostic algorithms, therapeutics and vaccines in this important but understudied population. Pediatric COVID-19 can be associated with subsequent multisystem inflammatory syndrome in children (MIS-C), but how these pathologies are related or differ is unclear. Here the authors compare and contrast pediatric COVID-19 and MIS-C immunophenotypes using SARS-CoV-2 antibody fingerprinting proteomics.
Association of mold levels in urban children’s homes with difficult-to-control asthma
Authors: Stephen Vesper, Larry Wymer, John Kroner, Jacqueline A. Pongracic, Edward M. Zoratti, Frédéric F. Little, Robert A. Wood, Carolyn M. Kercsmar, Rebecca S. Gruchalla, Michelle A. Gill, Meyer Kattan, Stephen J. Teach, Shilpa Patel, Christine C. Johnson, Leonard B. Bacharier, James E. Gern, Daniel J. Jackson, Steven M. Sigelman, Alkis Togias, Andrew H. Liu, William W. Busse, Gurjit K. Khurana Hershey
Journal: Journal of Allergy and Clinical Immunology (2021)
Is Thrombolytic Therapy, Using t-PA and/or Urokinase, Effective for Acute Pulmonary Embolism?
Authors: Kusa Shigeki, Ohyama Akiko, Kanoh Hiroto, Higuchi Kouji, Suzuki Atsushi, Sekiguchi Yukio, Yamauchi Yasuteru, Miyamoto Takamichi, Obayashi Tohru, Niwa Akihiro, Isobe Mitsuaki
Journal: Circulation (2006)
1440TiP Preventive HIPEC in combination with perioperative FLOT versus FLOT alone for resectable diffuse type gastric and gastroesophageal junction type II/III adenocarcinoma: The phase III “PREVENT” trial of the AIO/CAOGI/ACO
Authors: U.S. Bankstahl, S-E. Al-Batran, P. Piso, S. Lorenzen, M. Ostrzyzek, C. Pauligk, T. Habibzade, M. Schenk, A. Schlenska-Lange, D. Reim, W.O. Bechstein, A. Königsrainer, S.P. Mönig, B. Rau, M. Schwarzbach, T.O. Götze
Journal: Annals of Oncology (2021)
1525MO Phase I/II study of MAK683 in patients (pts) with advanced malignancies including epithelioid sarcoma
Authors: R. Bahleda, Z.A. Wainberg, A. Spreafico, B. Ma, V. Subbiah, V. Ribrag, M. Duca, Y.Y. Fan, Y. Cheng, C. Lai, F. De Braud
Journal: Annals of Oncology (2021)
Relevance of the Sry-HMG box gene, SOX4, in lung cancer.
Authors: Sandra Castillo, Pedro Medina, Sandra Blanco, Marta Sanz-Garcia, Octavio Romero, Barbara Angulo, Juan Cigudosa, Pedro Lazo, Montse Sanchez-Cespedes
Journal: Cancer Research (2008)

1771  The search for oncogenes is becoming increasingly important in cancer genetics because they constitute suitable targets for therapeutic intervention. We performed high-resolution CGH (Comparative Genome Hybridization) analysis on cDNA microarrays and compared DNA copy number and mRNA expression levels of over 8,000 genes in lung cancer cell lines. We observed amplification at 6p21-22 in lung cancer cell lines and in primary tumors and identified SOX4 as one gene selectively over-expressed and thus, a good oncogene candidate. SOX4 had over 14-fold increased expression in cells with amplification relative to normal cells. The SOX4, Sry-HMG box, gene encodes a transcription factor involved in embryonic cell differentiation and has been reported to be over-expressed in some cancer types such as those of the colon, prostate and bladder. To further determine its contribution to lung carcinogenesis we used real time QPCR to compare the levels of the SOX4 transcript in a panel of lung cancer cell lines, lung primary tumors and normal lung tissues. Relative to GAPDH, about 10% of the lung cancer cell lines and primary tumors showed high levels of SOX4 expression which was more common in small cell lung cancer as compared to non-small cell lung cancer (P
688P Gene expression profiling (GEP) signatures associated with markers of sensitivity to immune and angiogenic therapy in clear-cell renal cell carcinoma (ccRCC) with sarcomatoid/rhabdoid features
Authors: P.M. Coelho Barata, S. Gulati, A. Elliott, A. Rao, E.F. Burgess, R. McKay, H.J. Hammers, B. Gartrell, S. Darabi, M.A. Bilen, D. Geynisman, N.A. Dawson, K. Poorman, M. Zibelman, T. Zhang, S. Wei, W.M. Korn, C. Nabhan, C.J. Ryan, E. Heath
Journal: Annals of Oncology (2021)
323P Clinical profile and prognosis of metastatic breast cancer with pseudocirrhosis: A rare and dismal condition
Authors: M.F. Simões, D.D.S. Sá, J. Suerdieck, M.D. Donadio, R.P. Souza, J.M.L.M. Pereira, M.C. Tavares, A.O. Saito, P.B.C. Pinto, A.C.S.L. Diniz, S.M. Sanches
Journal: Annals of Oncology (2021)
1372O CLDN 18.2-targeted CAR-T cell therapy in patients with cancers of the digestive system
Authors: C. Qi, Y. Qin, D. Liu, J. Gong, S. Ge, M. Zhang, Z. Peng, J. Zhou, X. Zhang, X. Peng, H. Wang, C. He, J. Xiao, Z. Li, L. Shen
Journal: Annals of Oncology (2021)
491P Lipid-engulfed macrophages at the root of gut carcinogenesis
Authors: E. Daveri, L. Sorrentino, B. Vergani, L. Cattaneo, L. Lalli, M. Cosimelli, M. Vitellaro, V. Huber, A. Cova, M. Gariboldi, A. Belfiore, B.E. Leone, M. Milione, L. Rivoltini
Journal: Annals of Oncology (2021)
1104P Functional imaging and clinical outcomes in grade 3 neuroendocrine tumors (NETs G3): A single-center retrospective analysis
Authors: A. Laffi, M. Colandrea, G. Buonsanti, V. Bagnardi, S. Frassoni, F. Spada, E. Pisa, M. Barberis, M. Rubino, M.C. Grana, N. Fazio
Journal: Annals of Oncology (2021)
Case 30-2021: A 47-Year-Old Man with Recurrent Unilateral Head and Neck Pain
Authors: Mark E. Lindsay, David M. Dudzinski, Byung C. Yoon, Michael R. Jaff, Joseph V. Thakuria
Journal: New England Journal of Medicine (2021)

A 47-year-old man with a history of cerebellar stroke presented with pain involving the left side of the neck and the right flank, which preceded pulsating head pain. Imaging studies revealed dissections of the left vertebral artery and right renal artery with infarction. Additional diagnostic tests were performed.
Considerations in the Study of Body Mass Index Variability
Authors: L. Parker Gregg, Sankar D. Navaneethan
Journal: Journal of the American Society of Nephrology (2021)

Clinical risk prediction models generally incorporate data points from an isolated point in time to prognosticate risk at the bedside. However, in clinical practice, it is impossible to ignore variability in biologic parameters (such as BP and blood sugar) that are dynamic, and that some individuals