tbuckley/cabot-search huggingface dataset:
Selective delivery of low-affinity IL-2 to PD-1+ T cells rejuvenates antitumor immunity with reduced toxicity
Authors: Zhenhua Ren, Anli Zhang, Zhichen Sun, Yong Liang, Jianfeng Ye, Jian Qiao, Bo Li, Yang-Xin Fu
Journal: Journal of Clinical Investigation (2022)

PD-1 signaling on T cells is the major pathway that limits T cell immunity, but the efficacy of anti-PD-1 therapy has been limited to a small proportion of patients with advanced cancers. We fortuitously observed that anti-PD-1 therapy depends on IL-2 signaling, which raises the possibility that a lack of IL-2 limits anti-PD-1-induced effector T cell expansion. To selectively deliver IL-2 to PD-1+CD8+ tumor-infiltrating lymphocytes (TILs), we engineered a low-affinity IL-2 paired with anti-PD-1 (PD-1-laIL-2), which reduced affinity to peripheral Treg cells but enhanced avidity to PD-1+CD8+ TILs. PD-1-laIL-2 exerted better tumor control and lower toxicity than single or mixed treatments. Mechanistically, PD-1-laIL-2 could effectively expand dysfunctional and tumor-specific CD8+ T cells. Furthermore, we discovered that presumably dysfunctional PD-1+TIM3+ TILs are the dominant tumor-specific T cells responding to PD-1-laIL-2. Collectively, these results highlight that PD-1-laIL-2 can target and reactivate tumor-specific TILs for tumor regression as a unique strategy with stronger efficacy and lower toxicity.
Clinical features of asthma with bronchiectasis
Authors: Toshihiro Shirai, Yoshihiro Kitahara, Kanami Tamura, Shuichi Sugiyama, Kohei Okawa, Kotaro Shiratori, Hiromasa Nakayasu, Toshihiro Masuda, Shingo Takahashi, Yutaro Kishimoto, Shogo Sakurai, Mika Saigusa, Taisuke Akamatsu, Akito Yamamoto, Satoru Morita, Kazuhiro Asada
Journal: Journal of Allergy and Clinical Immunology (2022)
LONG-TERM OUTCOMES OF HYPERTROPHIC CARDIOMYOPATHY PRESENTING DURING CHILDHOOD: RESULTS FROM A NATIONAL POPULATION-BASED STUDY OF CHILDHOOD CARDIOMYOPATHY
Authors: Peta M.a. Alexander, Katherine Lee, Alan Nugent, Christian Turner, Terry Robertson, Piers Daubeney, Andrew Davis, James Ramsay, Robert Justo, Tara Bharucha, Ingrid King, Robert G. Weintraub
Journal: Journal of the American College of Cardiology (2010)
Low neutralizing antibody titers after asymptomatic or non-severe SARS-CoV-2 infection over a 6-month assessment period
Authors: C. Lazor-Blanchet, P. Zygoura, U. Dafni, F. Lamoth, Z. Tsourti, M.A. Lobritz, J. Regina, B. Grandbastien, C. Fenwick, G. Pantaleo, T. Calandra, S. Meylan
Journal: Journal of Infection (2022)
LABP-73: A Novel NLRX1 Ligand for the Treatment of Chronic Asthma
Authors: Andrew Leber, Raquel Hontecillas, Nuria Tubau-Juni, Sarah Fitch, Sameeksha Alva, Jyoti Chauhan, Josep Bassaganya-Riera
Journal: Journal of Allergy and Clinical Immunology (2022)
Flow cytometric dna-ploidy and proliferative activity of diethylnitrosamine-induced hepatocellular carcinoma and pulmonary metastases in monkeys*1
Authors: K LAPIS
Journal: Hepatology (1995)

Flow cytometric DNA analysis was carried out on diethylnitrosamine (DEN) induced primary hepatocellular carcinomas (HCC) and lung metastases in monkeys. In analyzing one sample from each of 113 HCC cases, 76 (67.2%) were diploid and 37 (32.7%) aneuploid. When more samples were analyzed from the same tumorous liver, all of the 76 diploid cases maintained their pattern, whereas 5 (13.5%) of the aneuploid cases displayed both diploid and aneuploid DNA. Studies of lung metastases from 44 (28 diploid, 16 aneuploid) HCC cases showed that the DNA-ploidy pattern characterizing the primary HCC was preserved in the metastases in 78.6% of the diploid and 93.7% of the aneuploid cases. The average synthetic phase fraction (SPF) value for the diploid tumors was 7.7% and the aneuploid tumors 14.9%. The difference is highly significant (P < .01). Highly significant correlation was found between the DNA ploidy and the SPF values, both in the primary HCC (P = .0001) and the metastases (P = .0266). Of different tumor and host features examined, statistically significant correlation was only found between DNA-ploidy/SPF and the cytological tumor grade. This study represents the first DNAploidy analysis of HCC in monkeys. The data showed that diploid and aneuploid tumors displayed comparable metastatic potential. The DNA-ploidy pattern was preserved in the metastases in the majority of the cases.
Vasopressin and Methylprednisolone vs Placebo and Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest
Authors: Sunn Hoah Kelvin Yap
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Unique Multifunctional Nanoenzyme Tailored for Triggering Tumor Microenvironment Activated NIR‐II Photoacoustic Imaging and Chemodynamic/Photothermal Combined Therapy (Adv. Healthcare Mater. 3/2022)
Authors: Shulong Wang, Jingjin Zhao, Liangliang Zhang, Chaobang Zhang, Zhidong Qiu, Shulin Zhao, Yong Huang, Hong Liang
Journal: Advanced Healthcare Materials (2022)

Photoacoustic Imaging In article number 2102073 by Liangliang Zhang, Shulin Zhao, Hong Liang, and co-workers, an oxidized molybdenum polyoxometalate-copper nanocomposite is explored as a multifunctional nanoenzyme to trigger tumor microenvironment-activated NIR-II photoacoustic imaging and chemodynamic/photothermal combined therapy.
SARS-CoV-2 Infection and Hospitalization Among Adults Aged ≥18 Years, by Vaccination Status, Before and During SARS-CoV-2 B.1.1.529 (Omicron) Variant Predominance — Los Angeles County, California, November 7, 2021–January 8, 2022
Authors: Phoebe Danza, Tae Hee Koo, Meredith Haddix, Rebecca Fisher, Elizabeth Traub, Kelsey OYong, Sharon Balter
Journal: MMWR Morbidity and Mortality Weekly Report (2022)

COVID-19 vaccines are effective at preventing infection with SARS-CoV-2, the virus that causes COVID-19, as well as severe COVID-19-associated outcomes in real-world conditions (1,2). The risks for SARS-CoV-2 infection and COVID-19-associated hospitalization are lower among fully vaccinated than among unvaccinated persons; this reduction is even more pronounced among those who have received additional or booster doses (boosters) (3,4). Although the B.1.1.529 (Omicron) variant spreads more rapidly than did earlier SARS-CoV-2 variants, recent studies suggest that disease severity is lower for Omicron compared with that associated with the B.1.617.2 (Delta) variant; but the high volume of infections is straining the health care system more than did previous waves (5).*,† The Los Angeles County (LAC) Department of Public Health (LACDPH) used COVID-19 surveillance and California Immunization Registry 2 (CAIR2) data to describe age-adjusted 14-day cumulative incidence and hospitalization rates during November 7, 2021-January 8, 2022, by COVID-19 vaccination status and variant predominance. For the 14-day period ending December 11, 2021, the last week of Delta predominance, the incidence and hospitalization rates among unvaccinated persons were 12.3 and 83.0 times, respectively, those of fully vaccinated persons with a booster and 3.8 and 12.9 times, respectively, those of fully vaccinated persons without a booster. These rate ratios were lower during Omicron predominance (week ending January 8, 2022), with unvaccinated persons having infection and hospitalization rates 3.6 and 23.0 times, respectively, those of fully vaccinated persons with a booster and 2.0 and 5.3 times, respectively, those of fully vaccinated persons without a booster. In addition, during the entire analytic period, admission to intensive care units (ICUs), intubation for mechanical ventilation, and death were more likely to occur among unvaccinated persons than among fully vaccinated persons without or with a booster (p<0.001). Incidence and hospitalization rates were consistently highest for unvaccinated persons and lowest for fully vaccinated persons with a booster. Being up to date with COVID-19 vaccination is critical to protecting against SARS-CoV-2 infection and associated hospitalization.
Vitamin D and fish oil supplements and risk of autoimmune disease
Authors: Karen H Costenbader
Journal: BMJ (2022)

A question most physicians hear almost daily is "Doctor, which vitamins or supplements do you recommend that I take?"This was a question that my colleagues and I set out to answer in the Autoimmune Disease Prevention ancillary study in the VITAL trial. 1 Now, when my patients, colleagues, or friends ask me, I can point to our research findings, which suggest that for women age 55 years and older, and men 50 years and older, marine omega-3 fatty acids (fish oil) 1000 mg a day, and vitamin D 2000 IU a day-the doses used in VITAL-lead to a 22% reduction in all autoimmune diseases with vitamin D, and a 15% reduction in the same with fish oil supplementation over 5.3 years of randomised follow-up.In the trial, these supplements were prescription grade and underwent rigorous quality testing.They were safe and well tolerated and no increase in adverse events was found.For individuals obtaining these supplements over the counter, I also recommend that they check the safety seals for quality assurance as these products are not always as well tested.
Practices of therapeutic drug monitoring in tuberculosis: an international survey
Authors: Ioana Margineanu, Onno Akkerman, Dario Cattaneo, Delia Goletti, Deborah J.E. Marriott, Giovanni Battista Migliori, Fuad Mirzayev, Charles A. Peloquin, Ymkje Stienstra, Jan-Willem Alffenaar
Journal: European Respiratory Journal (2022)

<b>Survey responses indicate that there is concern surrounding cost-effectiveness and the resources available in different settings to implement therapeutic drug monitoring in TB. Robust research is needed to better inform of the potential long-term benefits.</b>https://bit.ly/34PFSfd
The Modern Treatment of Nervous and Mental Diseases.
Journal: JAMA (1913)

The somewhat unusual point of view from which this work regards the subject presented is deserving of attention. Instead of beginning with the physical as primary and making the psychic a mere appendage, the authors approach the diseases of the nervous system from a conception of life in which the psychic is deemed worthy of quite as much consideration as the physical. The authors think that previous writers have been too much concerned with details, such as disorders of gait, of power, of sensation and of related phenomena, to the neglect of the larger problem of the individual, the biologic unit and his social relations. "Practically all such works have stopped short where they should have begun. They have told us in large measure how to patch up broken machinery, but rarely have they ever suggested or given directions for avoiding the wrecks." The point of view is essentially therapeutic
The flowering of plastic surgery
Authors: B. Cannon
Journal: JAMA (1990)

PLASTIC surgery, unlike most surgical specialties, has no anatomic or functional area to which it can lay claim; the plastic surgeon practices methods and techniques applicable to all specialties and anatomic areas. My first exposure to plastic surgery was as a medical student when I watched Varaztad H. Kazanjian, DMD, MD, reconstruct a nose with a forehead flap—the ancient Indian method. I was greatly intrigued. A decade later, I became his fast friend, admirer, and professional colleague, and, in 1941, succeeded him as chief of the Plastic Clinic at the Massachusetts General Hospital (MGH), Boston. Having spent my childhood in Cambridge, Mass, and 8 years of higher education at Harvard University, Cambridge, it seemed appropriate that I go elsewhere for my postgraduate training. When the opportunity arose to intern at Barnes Hospital in St Louis, Mo, I chose to leave Boston. (There was no matching plan in those days.) Quite
Geometric differences of mitral valvular apparatus between ischemic and dilated cardiomyopathy with significant mitral regurgitation: real-time three-dimensional echocardiography study
Authors: Jun Kwan, Takahiro Shiota, A.Marc Gillinov, Deborah A. Agler, None Jian Xin Qin, None Yong Jin Kim, James D. Thomas
Journal: Journal of the American College of Cardiology (2002)
68Ga-DOTA-FAPI-04 Uptake of Accessory Breast in a Patient With Breast Cancer
Authors: Tingting Xu, Wei Wang, Chuan Yang, Liang Cai, Yue Chen
Journal: Clinical Nuclear Medicine (2022)

68Ga-DOTA-FAPI-04 is a promising PET agent for tumor imaging. However, some nonneoplastic lesions can also show increased FAPI uptake. Herein, we presented a case of a patient with left breast cancer who showed a right accessory breast with increased tracer uptake on 68Ga-DOTA-FAPI-04 PET/CT. Final histopathology confirmed there were no malignant components in the accessory breast.
Miscellanea Medica
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gut Microbiome Composition Is Predictive of Incident Type 2 Diabetes in a Population Cohort of 5,572 Finnish Adults
Authors: Matti O. Ruuskanen, Pande P. Erawijantari, Aki S. Havulinna, Yang Liu, Guillaume Méric, Jaakko Tuomilehto, Michael Inouye, Pekka Jousilahti, Veikko Salomaa, Mohit Jain, Rob Knight, Leo Lahti, Teemu J. Niiranen
Journal: Diabetes Care (2022)

To examine the previously unknown long-term association between gut microbiome composition and incident type 2 diabetes in a representative population cohort.We collected fecal samples from 5,572 Finns (mean age 48.7 years; 54.1% women) in 2002 who were followed up for incident type 2 diabetes until 31 December 2017. The samples were sequenced using shotgun metagenomics. We examined associations between gut microbiome composition and incident diabetes using multivariable-adjusted Cox regression models. We first used the eastern Finland subpopulation to obtain initial findings and validated these in the western Finland subpopulation.Altogether, 432 cases of incident diabetes occurred over the median follow-up of 15.8 years. We detected four species and two clusters consistently associated with incident diabetes in the validation models. These four species were Clostridium citroniae (hazard ratio [HR] 1.21; 95% CI 1.04-1.42), C. bolteae (HR 1.20; 95% CI 1.04-1.39), Tyzzerella nexilis (HR 1.17; 95% CI 1.01-1.36), and Ruminococcus gnavus (HR 1.17; 95% CI 1.01-1.36). The positively associated clusters, cluster 1 (HR 1.18; 95% CI 1.02-1.38) and cluster 5 (HR 1.18; 95% CI 1.02-1.36), mostly consisted of these same species.We observed robust species-level taxonomic features predictive of incident type 2 diabetes over long-term follow-up. These findings build on and extend previous mainly cross-sectional evidence and further support links between dietary habits, metabolic diseases, and type 2 diabetes that are modulated by the gut microbiome. The gut microbiome can potentially be used to improve disease prediction and uncover novel therapeutic targets for diabetes.
The Evolving Complexity of the Podocyte Cytoskeleton
Authors: Christoph Schell, Tobias B. Huber
Journal: Journal of the American Society of Nephrology (2017)

Podocytes exhibit a unique cytoskeletal architecture that is fundamentally linked to their function in maintaining the kidney filtration barrier. The cytoskeleton regulates podocyte shape, structure, stability, slit diaphragm insertion, adhesion, plasticity, and dynamic response to environmental stimuli. Genetic mutations demonstrate that even slight impairment of the podocyte cytoskeletal apparatus results in proteinuria and glomerular disease. Moreover, mechanisms underpinning all acquired glomerular pathologies converge on disruption of the cytoskeleton, suggesting that this subcellular structure could be targeted for therapeutic purposes. This review summarizes our current understanding of the function of the cytoskeleton in podocytes and the associated implications for pathophysiology.
CircZNF652 promotes the goblet cell metaplasia by targeting the miR-452-5p/JAK2 signaling pathway in allergic airway epithelia
Authors: Xiangzhi Wang, Chengyun Xu, Yuqing Cai, Xinyi Zou, Yunqi Chao, Ziyi Yan, Chaochun Zou, Ximei Wu, Lanfang Tang
Journal: Journal of Allergy and Clinical Immunology (2022)

Circular RNAs (circRNAs) play potentially important roles in various human diseases; however, their roles in the goblet cell metaplasia of asthma remain unknown.We sought to investigate the potential role and underlying mechanism of circZNF652 in the regulation of allergic airway epithelial remodeling.The differential expression profiles of circRNAs were analyzed by transcriptome microarray, and the effects and mechanisms underlying circZNF652-mediated goblet cell metaplasia were investigated by quantitative real-time PCR, RNA fluorescence in situ hybridization, Western blot, RNA pull-down, and RNA immunoprecipitation analyses. The roles of circZNF652 and miR-452-5p in allergic airway epithelial remodeling were explored in both the mouse model with allergic airway inflammation and children with asthma.One hundred sixty circRNAs were differentially expressed in bronchoalveolar lavage fluid of children with asthma versus children with foreign body aspiration, and 52 and 108 of them were significantly upregulated and downregulated, respectively. Among them, circZNF652 was predominantly expressed and robustly upregulated in airway epithelia of both the children with asthma and the mouse model with allergic airway inflammation. circZNF652 promoted the goblet cell metaplasia by functioning as a sponge of miR-452-5p, which released the Janus kinase 2 (JAK2) expression and subsequently activated JAK2/signal transducer and activator of transcription 6 (STAT6) signaling in the allergic airway epithelia. In addition, epithelial splicing regulatory protein 1, a splicing factor, accelerated the biogenesis of circZNF652 by binding to its flanking intron to promote the goblet cell metaplasia in allergic airway epithelial remodeling.Upregulation of circZNF652 expression in allergic bronchial epithelia contributed to the goblet cell metaplasia by activating the miR-452-5p/JAK2/STAT6 signaling pathway; thus, blockage of circZNF652 or agonism of miR-452-5p provided an alternative approach for the therapeutic intervention of epithelial remodeling in allergic airway inflammation.
Clinical Features and Outcomes of Severe Pneumonia Caused by Endemic Human Coronavirus in Adults
Authors: Hyemin Chung, Sang-Bum Hong, Jin Won Huh, Heungsup Sung, Kyung-Hyun Do, Sang-Oh Lee, Chae-Man Lim, Younsuck Koh, Sang-Ho Choi
Journal: American Journal of Respiratory and Critical Care Medicine (2022)
Effectiveness of Laboratory Testing in the Management of Chronic Urticaria/Angioedema
Authors: Kavya Reddy, Karol Avila, Ismael Carrillo-Martin, Sergio Chiarella, Rohit Divekar, Wendy Garzon Siatoya, Dan Morgenstern-Kaplan, Miguel Park, Matthew Rank, Masih Rezaee, Gerald Volcheck, Alexei Gonzalez-Estrada
Journal: Journal of Allergy and Clinical Immunology (2022)
Hypertonic Saline-Induced Abortion
Authors: Helen I. Glueck
Journal: JAMA (1973)

Earlier studies of the coagulation mechanism in patients undergoing hypertonic saline-induced abortion yielded data ranging from a normal clotting mechanism to evidence of frank disseminated intravascular coagulation. Because of this wide variability, patients were monitored to determine the moment of fetal death and the relationship of this episode to the appearance of circulating soluble fibrin and fibrin split products. Circulating soluble fibrin measured by a new technique was detected in seven of eight patients at the time of fetal death. Elevation of the level of fibrin split products, as well as modest depressions of factor VIII and fibrinogen were detected somewhat later. Values for factor VIII and fibrinogen did not fall to levels usually associated with hemorrhage. Thus, disseminated intravascular coagulation can occur without the classically described changes in the clotting mechanism.
基底细胞痣综合征(Gorlin 综合征)患者临床管理指南
Journal: British Journal of Dermatology (2022)

Journal Article 基底细胞痣综合征(Gorlin 综合征)患者临床管理指南 Get access British Journal of Dermatology, Volume 186, Issue 2, 1 February 2022, Page e99, https://doi.org/10.1111/bjd.20927 Published: 01 February 2022