tbuckley/cabot-search huggingface dataset:
BMI and cardiorespiratory fitness predicted mortality in older adults
Authors: Anna Peeters
Journal: Annals of Internal Medicine (2008)

ACP Journal Club20 May 2008BMI and cardiorespiratory fitness predicted mortality in older adultsAnna Peeters, PhDAnna Peeters, PhDMonash University, Melbourne, Victoria, Australia (A.P.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-10-200805200-02012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationSui X, LaMonte MJ, Laditka JN, et al. Cardiorespiratory fitness and adiposity as mortality predictors in older adults. JAMA. 2007;298:2507-16. https://pubmed.ncbi.nlm.nih.gov/185056904Clinical Impact RatingsGIM/FP/GP: Geriatrics: References1 Villareal DT, Apovian CM, Kushner RF, et al. Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society. Obes Res. 2005;13:1849-63. [PMID: 16339115] Google Scholar2 Janssen I, Mark AE. Elevated body mass index and mortality risk in the elderly. Obes Rev. 2007;8:41-59. [PMID: 17212795] Google Scholar Author, Article, and Disclosure InformationAffiliations: Monash University, Melbourne, Victoria, Australia (A.P.)This article was published at Annals.org on 6 May 2008. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoIncreasing BMI was associated with increasing risk for overall cancer incidence and mortality in middle-aged women Anna Peeters The combination of low midarm muscle circumference and high waist circumference predicted higher mortality in older men Anna Peeters Metrics 20 May 2008Volume 148, Issue 10Page: JC3-12KeywordsAdipose tissueBody mass indexCohort studiesElderlyExerciseMortalityMusclesObesityOverweightPopulation statistics ePublished: 20 May 2008 Issue Published: 20 May 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Psychiatry
Authors: Richard M. Glass
Journal: JAMA (1989)

About 15% of adults in US communities meet diagnostic criteria for psychiatric disorders.<sup>1</sup>These are even more common in both adult<sup>2</sup>and pediatric<sup>3</sup>primary care practices, with respective prevalence rates of 27% and 22%. The impact on medical practice is striking, since nonpsychiatrists account for 83% of physician visits in which psychotropic drugs are prescribed.<sup>4</sup>Hence, we survey some of the recent developments in psychiatric drug treatment. Extensive research documents the efficacy of psychopharmacologic treatments for patients with major depression (who often consult primary care physicians for sleep and appetite disturbance and other somatic complaints) or bipolar disorder, with its episodic mania or submanic moods and depression. Major depression, a potentially lethal disorder that is probably increasing among younger birth cohorts,<sup>5</sup>is often unrecognized or inadequately treated. Accordingly, the National Institute of Mental Health in 1988 launched its Depression/Awareness, Recognition, and Treatment Program, the first
Index to advertisers
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Underwater drainage.
Authors: R. L. Wynne
Journal: BMJ (1968)

MEDICAJOURAulcer.When this was developing in its characteristically intractable manner the mucosa was in the process of disintegration, and a true hyposecretion is the result.In cases of complete metaplasia there was an invariable achlorhydria.Other factors may increase the speed and severity of the ulcer progression, but are unlikely to be the cause of it.-Iam, etc., Scarborough, Yorks.
Progress Toward Poliomyelitis Eradication--Afghanistan, 1994-1999
Journal: JAMA (1999)

In 1988, the World Health Assembly of the World Health Organization (WHO) resolved to eradicate poliomyelitis globally by 2000. During the same year, the Eastern Mediterranean Region (EMR) of WHO passed a resolution to join the global initiative. Since then, substantial progress has been made worldwide and in EMR member countries. Afghanistan, with ongoing civil conflict, initiated polio eradication activities in 1994. Since then, a countrywide surveillance system for acute flaccid paralysis (AFP) was established and National Immunization Days (NIDs) were implemented. This report summarizes the achievements toward polio eradication in Afghanistan during 1999-2000.
TRUMAN W. MILLER, M.D.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The autonomy of idiopathic erosive proctitis
Authors: E. D. Palmer
Journal: JAMA (1975)

HIGH ON the list of badly underpublicized diseases of the gastrointestinal tract stands idiopathic erosive proctitis. Its poor press is explained by the usual habit of lumping it with common ulcerative colitis. The fact: it is an entirely different disease, no more like ulcerative colitis than amebic colitis. <h3>The Subjective Picture</h3> Idiopathic erosive proctitis usually begins during the third or fourth decade. Most patients are women, although I am unable to suggest in what proportion. To the patient, the onset seems sudden. The patient feels well but all at once sees red blood on stool or toilet tissue. Rectal bleeding is the main manifestation at the beginning and throughout the course of the illness. It tends to persist daily for many weeks or months, sometimes with brief periods of spontaneous improvement, but in most patients it shows a doggedness that leads to chronic discouragement among all concerned. The blood is
Randomized phase 2 trial of peri- or post-operative chemotherapy in resectable pancreatic adenocarcinoma
Authors: M. Reni, S. Zanon, G. Balzano, R. Castoldi, A. Zerbi, M.C. Tronconi, D. Pinelli, S. Mosconi, C. Doglioni, M. Falconi, L. Gianni
Journal: Annals of Oncology (2017)
West Nile Virus Activity—United States, January 1–December 1, 2005
Journal: JAMA (2006)

West Nile virus (WNV) is the leading cause of arboviral encephalitis in the United States. Originally discovered in Africa in 1937, WNV was first detected in the western hemisphere in 1999 in New York City. Since then it has caused seasonal epidemics of febrile illness and severe neurologic disease. During January 1-December 1, 2005, a total of 2,744 cases of WNV disease in humans were reported in the United States, an increase from 2,359 during the same period in 2004. A total of 1,165 cases were WNV neuroinvasive disease (WNND). WNV infections in humans, birds, mosquitoes, and nonhuman mammals are reported to CDC through ArboNET, an Internet-based arbovirus surveillance system managed by state health departments and CDC. During 2005, WNV transmission to humans or animals expanded into 21 counties that had not previously reported transmission and recurred in 1,196 counties where transmission had been reported in previous years. This report summarizes provisional WNV surveillance data through December 1, 2005, and highlights the need for ongoing surveillance, mosquito control, promotion of personal protection from mosquito bites, and research into additional prevention strategies.
Neurosurgery
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genetic Risk Factors for Sclerotic Graft-Versus-Host Disease
Authors: Yoshihiro Inamoto, Paul J. Martin, Mary E. Flowers, Stephanie J. Lee, Paul A. Carpenter, Edus Houston Warren, Michael Boeckh, Barry E. Storer, David Levine, Wenhong Fan, Lue Ping Zhao, John A. Hansen
Journal: Blood (2014)
Refractory ascites in cirrhosis: Roles of volume expansion and plasma atrial natriuretic factor level elevation
Authors: F Wong
Journal: Hepatology (1993)

Cirrhotic patients with ascites refractory to diuretics also have blunted response to marked elevations of plasma atrial natriuretic factor levels alone or to moderate intravascular volume expansion by head-out water immersion. However, these patients usually undergo natriuresis after peritoneovenous shunting. To dissect the factors responsible for this response, we studied the effects on separate days of moderate intravascular volume expansion and highly elevated plasma atrial natriuretic factor levels (head-out water immersion and atrial natriuretic factor infusion) or marked volume expansion and moderate plasma atrial natriuretic factor level elevation (head-out water immersion and albumin infusion) in 13 alcoholic cirrhotic patients with massive ascites. Three of these patients, who responded to initial head-out water immersion with a negative sodium balance, served as controls. Unresponsiveness to head-out water immersion was confirmed in the remaining 10 patients on both days on the basis of blunted natriuretic response (urinary sodium excretion < 0.8 mmol/hr after 2 hr). In contrast, these 10 refractory patients were able to achieve negative sodium balance with both combinations. Mean urinary sodium excretion increased from a baseline level of 0.13 ± 0.10 mmol/hr to a peak level of 2.29 ± 0.61 mmol/hr after head-out water immersion and atrial natriuretic factor infusion and from 0.10 ± 0.3 mmol/hr to 1.61 ± 0.62 mmol/hr after head-out water immersion and albumin infusion. Both maneuvers were associated with suppression of plasma renin activity and serum aldosterone levels. With head-out water immersion and atrial natriuretic factor infusion, we noted a significant increase in 5′ cyclic GMP levels, a second messenger of atrial natriuretic factor, indicating possible activation of atrial natriuretic factor receptors at the inner medullary collecting ducts. In contrast, with head-out water immersion and albumin infusion no such increase in levels occurred, indicating that the increase in urinary sodium excretion was mainly due to increased delivery of sodium to the cortical distal nephron, as indicated by a disproportionate increase in urinary potassium excretion. In conclusion, massive (as opposed to moderate) volume expansion or greatly elevated levels of plasma atrial natriuretic factor associated with moderate volume expansion can improve blunted atrial natriuretic factor responsiveness in cirrhotic patients with refractory ascites. This appears to be achieved by way of a marked increase in distal delivery of filtrate in the kidney, with or without activation of distal atrial natriuretic factor receptors in the inner medullary collecting ducts. (HEPATOLOGY 1993;18:519–528.)
Abstract P027: Liver Enzymes and Insulin Resistance and Glycemia in Hispanic/Latino Youth: Results From the Hispanic Community Children’s Health Study/Study of Latino Youth (SOL Youth)
Authors: Christina M Parrinello, Bryan J Rudolph, Mariana Lazo, Linda C Gallo, Bharat Thyagarajan, Scott J Cotler, Qibin Qi, Denise C Vidot, Howard D Strickler, Robert C Kaplan, Carmen R Isasi
Journal: Circulation (2016)

Background: Associations of insulin resistance and glycemia with liver enzymes have not been well studied in a young, heterogeneous Hispanic/Latino population. We aimed to assess these associations, and to examine the role of endothelial dysfunction as a potential mediator. Methods: We examined 1,275 participants aged 8-16 years from the Hispanic Community Children’s Health Study/Study of Latino Youth (SOL Youth) (2012-14). We examined the distribution of liver enzymes (alanine transaminase [ALT], aspartate transaminase [AST], and gamma-glutamyl transpeptidase [GGT]), the pediatric nonalcoholic fatty liver disease (NAFLD) fibrosis index (PNFI), glycemic markers (fasting glucose and hemoglobin A1c [HbA1c]), and insulin resistance (HOMA-IR) by age, sex, and body mass index (BMI). We assessed the adjusted cross-sectional associations of insulin resistance and hyperglycemia (as continuous variables) with elevated liver enzymes and PNFI (as binary variables) using Poisson regression to obtain prevalence ratios (PRs). Results: Boys were more likely than girls to have elevated liver enzyme levels (15 vs 10%, 5 vs 2%, 26 vs 16%, and 12 vs 11% had elevated ALT, AST, GGT, and PNFI, respectively) and hyperglycemia (15 vs 6% and 9 vs 8% had elevated glucose and HbA1c), but less likely to be insulin resistant (47 vs 59%). Obese children (BMI≥95 th percentile) were more likely to have higher liver enzyme levels, hyperglycemia, and insulin resistance than non-obese children. Only HOMA-IR was associated with elevated liver enzymes and PNFI in multivariable models ( Figure ). After additional adjustment for PAI-1, and e-selectin (markers of endothelial dysfunction), only the associations of HOMA-IR with GGT and PNFI remained statistically significant (PRs and 95% CIs: 1.43 [1.03, 1.98] and 1.85 [1.33, 2.56], respectively). Conclusions: Among a large sample of Hispanic/Latino youths, insulin resistance was associated with NAFLD. It is possible that these associations are partially mediated by endothelial dysfunction.
Vice President Bush Asks Cancer Panel to Study Drug Regulation
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article Vice President Bush Asks Cancer Panel to Study Drug Regulation Get access JNCI: Journal of the National Cancer Institute, Volume 80, Issue 11, 3 August 1988, Page 794, https://doi.org/10.1093/jnci/80.11.794 Published: 03 August 1988
Julius Hoenig
Authors: M L D Fernando, U. Sirinivasan
Journal: BMJ (2009)

<h3>Background</h3> Based on a behavioural medicine perspective, modern recommendations for physical therapists treating patients with spinal pain include performing a trustworthy physical examination, conveying the message that back pain is benign, and stressing that activity is a key to recovery. However, little evidence is available on how patients perceive these biopsychosocial messages and how a patient9s perceptions of these messages relate to their recovery. <h3>Objectives</h3> The aim of this study is to explore the relationship between perceptions of treatment delivery that are related to an evidence-based approach and psychological factors, treatment outcome and treatment satisfaction. <h3>Design</h3> Cohort study with 3 measurement points <h3>Methods</h3> Data on a total of 281 patients was collected. <h3>Results</h3> High catastrophizing and lower mood in patients were correlated to “Not perceiving the bio psychosocial message” measured 6 weeks after treatment start. Patients who didn9t perceive the biopsychosocial message were at higher risk for disability and had lower treatment satisfaction 6 months after treatment start even when controlling for pretreatment pain intensity. “Not perceiving the biopsychosocial message” was not a mediator for treatment outcome and treatment satisfaction. Physical therapist9s treatment orientation or attitudes were not related to the perception of the message by the patients. <h3>Limitations</h3> There was no measure of actual practice behaviour. <h3>Conclusions</h3> Maladaptive cognitions and negative emotions seem to affect the way information provided during treatment is perceived by patients. The way information is perceived by patients, influences treatment outcome and treatment satisfaction. Physical therapists are advised to check that patients with higher levels of catastrophizing and lower mood perceived and interpreted a biopsychosocial message in the way it was intended.
index to advertisers
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Implications of inflammatory changes on cervical cytology.
Journal: BMJ (1990)

leucocytes, in addition, does not automatically imply inflammation.As is known, these non- discrete criteria lend themselves to extensive interobserver variation in reporting.The statement that the study population was selected solely by returned cytology forms implies that no single observer reported the results of all of the tests.Indeed, the results were probably reported by many observers of varying ability and experience.It would have been prudent to have had a single cvtopathologist to review all of the preparations in this study.Furthermore, the fact that some slides were unsatisfactory shows that the selection was flawed.It is worth noting that many of the infections discussed may be identified from cytological preparations: Candida albicans, Gardnerella vaginalis, Trichomonas vaginalis, and herpes simplex virus.If identified these may be listed as
Tremelimumab: A monoclonal antibody against CTLA-4—In combination with radiofrequency ablation (RFA) in patients with biliary tract carcinoma (BTC).
Authors: Austin G. Duffy, Drew Pratt, David E Kleiner, Donna Mabry, Suzanne Fioravanti, Melissa Walker, William Douglas Figg, Seth M. Steinberg, Victoria Anderson, Venkatesh Krishnasamy, Bradford J. Wood, Tim F. Greten
Journal: Journal of Clinical Oncology (2017)

316 Background: Tremelimumab is a fully human monoclonal antibody that binds to CTLA-4 expressed on the surface of activated T lymphocytes and results in inhibition of B7-CTLA-4-mediated downregulation of T-cell activation. Radiofrequency ablation (RFA) has been shown to induce a peripheral immune response which may enhance the effect of anti-CTLA4 treatment. Methods: Patients with refractory BTC were enrolled in a study of monthly Tremelimumab (10mg/kg, 6 doses) combined with RFA (to one lesion) performed on week 6. Tumor biopsies were performed at time of RFA with regular PBMC collection for intensive immunemontoring. Results: 17 pts enrolled. Characteristics: M:F 8:9; Median age 57(range 36-67); BTC subtype - intrahepatic/exrahepatic: 12/5. 13/17 had metastatic disease. All pts were chemorefractory with 12/17 having received at least 2 regimens. While on study, 6 pts had early PD within 6 weeks; 11 were able to undergo RFA. No DLT encountered. Most common toxicity was pruritus. There were no objective responses. Of evaluable pts N = 6 (55%) had stable disease as a best response. Conclusions: Tremelimumab in combination with subtotal RFA in patients with advanced BTC is safe and feasible. No objective responses have so far been seen in this predominantly primary intrahepatic BTC population. Full efficacy and immune monitoring data will be presented. Clinical trial information: NCT01853618.