Acquired C1 Esterase Inhibitor Deficiency
Authors: Marco Cicardi
Journal: Annals of Internal Medicine (2000)

Letters21 November 2000Acquired C1 Esterase Inhibitor DeficiencyMarco Cicardi, MD, Angelo Agostoni, MD, and Alvin E. Davis III, MDMarco Cicardi, MDUniversity of Milan; Milan, Italy (Cicardi, Agostoni)Center for Blood Research; Boston, MA 02115 (Davis)Search for more papers by this author, Angelo Agostoni, MDUniversity of Milan; Milan, Italy (Cicardi, Agostoni)Center for Blood Research; Boston, MA 02115 (Davis)Search for more papers by this author, and Alvin E. Davis III, MDUniversity of Milan; Milan, Italy (Cicardi, Agostoni)Center for Blood Research; Boston, MA 02115 (Davis)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-10-200011210-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Markovic and colleagues' review (1) contains many unsupported statements that may promote inappropriate therapy. The authors' statements that corticosteroids, epinephrine, heparin, and antihistamines are effective therapy for acquired angioedema are misleading. No convincing published evidence suggests that any of these agents is effective therapy for either form of the disease. If the retrospective analysis of the patients treated at the Mayo Clinic indicates efficacy of these agents, these data should have been presented. In addition, both replacement therapy with C1 inhibitor concentrate and prophylaxis with androgen derivatives are frequently ineffective or marginally effective in acquired C1 inhibitor ...References1. Markovic SN, Inwards DJ, Frigas EA, Phyliky RP. Acquired C1 esterase inhibitor deficiency. Ann Intern Med. 2000;132:144-50. LinkGoogle Scholar2. Cicardi M, Bergamaschini L, Cugno M, Beretta A, Zingale LC, Colombo M, et al . Pathogenetic and clinical aspects of C1 inhibitor deficiency. Immunobiology. 1998;199:366-76. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Milan; Milan, Italy (Cicardi, Agostoni)Center for Blood Research; Boston, MA 02115 (Davis) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAcquired C1 Esterase Inhibitor Deficiency Svetomir N. Markovic , David J. Inwards , Evangelos A. Frigas , and Robert P. Phyliky Acquired C1 Esterase Inhibitor Deficiency Allen P. Kaplan Acquired C1 Esterase Inhibitor Deficiency Antal Csepregi and Elemér Nemesánszky Acquired C1 Esterase Inhibitor Deficiency Svetomir N. Markovic , David J. Inwards , and Robert P. Phyliky Acquired C1 Esterase Inhibitor Deficiency Teresa Caballero , Maria Concepcion Lopez-Serrano , and Margarita Lopez-Trascasa Acquired C1 Esterase Inhibitor Deficiency Thomas Grünewald Metrics Cited byProtease inhibitors in the treatment of hereditary angioedema 21 November 2000Volume 133, Issue 10Page: 837-838KeywordsAngiotensin converting enzyme inhibitorAntihistaminesAutoantibodiesCorticosteroid therapyEpinephrineEsterasesHeparinPathogenesisProphylaxisResearch design ePublished: 21 November 2000 Issue Published: 21 November 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...