tbuckley/cabot-search huggingface dataset:
Screening for Eating Disorders in Adolescents and Adults
Authors: Karina W. Davidson, Michael J. Barry, Carol M. Mangione, Michael Cabana, David Chelmow, Tumaini Rucker Coker, Esa M. Davis, Katrina E. Donahue, Carlos Roberto Jaén, Martha Kubik, Li Li, Gbenga Ogedegbe, Lori Pbert, John M. Ruiz, Michael Silverstein, James Stevermer, John B. Wong
Journal: JAMA (2022)

Eating disorders (eg, binge eating disorder, bulimia nervosa, and anorexia nervosa) are a group of psychiatric conditions defined as a disturbance in eating or eating-related behaviors that impair physical or psychosocial functioning. According to large US cohort studies, estimated lifetime prevalences for anorexia nervosa, bulimia nervosa, and binge eating disorder in adult women are 1.42%, 0.46%, and 1.25%, respectively, and are lower in adult men (anorexia nervosa, 0.12%; bulimia nervosa, 0.08%; binge eating disorder, 0.42%). Eating disorder prevalence ranges from 0.3% to 2.3% in adolescent females and 0.3% to 1.3% in adolescent males. Eating disorders are associated with short-term and long-term adverse health outcomes, including physical, psychological, and social problems. The US Preventive Services Task Force (USPSTF) commissioned a systematic review to evaluate the benefits and harms of screening for eating disorders in adolescents and adults with a normal or high body mass index. Evidence limited to populations who are underweight or have other physical signs or symptoms of eating disorders was not considered. The USPSTF has not previously made a recommendation on this topic. Adolescents and adults (10 years or older) who have no signs or symptoms of eating disorders (eg, rapid weight loss, weight gain, or pronounced deviation from growth trajectory; pubertal delay; bradycardia; oligomenorrhea; and amenorrhea). The USPSTF concludes that the evidence is insufficient to assess the balance of benefits and harms of screening for eating disorders in adolescents and adults. The evidence is limited and the balance of benefits and harms cannot be determined. The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for eating disorders in adolescents and adults. (I statement).
TRICUSPID VALVE DISEASE AND RIGHT VENTRICULAR DYSFUNCTION AFTER RIGHT VENTRICULAR TRANSVENOUS LEAD PLACEMENT IN PATIENTS WITH TRICUSPID VALVE PROSTHESIS
Authors: Jasneet Devgun, Elsheikh Abdelrahim, Faiza Ahmed, Ahmed Kazem, Gulmohar Singh-Kucukarslan, Hassan Nemeh, Waddah Maskoun
Journal: Journal of the American College of Cardiology (2022)
MASS EFFECT: AN UNUSUAL CAUSE OF VENTRICULAR TACHYCARDIA
Authors: Lukasz Patrick Cerbin, Christopher Barrett, James Mann, Syed Rafay Ali Sabzwari, Daniel Wadsworth Groves, Amneet Sandhu, Alexis Z. Tumolo, Wendy S. Tzou, John Jason West, Matthew Michael Zipse, Michael Rosenberg
Journal: Journal of the American College of Cardiology (2022)
A MACHINE LEARNING APPROACH TO CONGLOMERATE MULTIPLE DETERMINANTS OF DELAYED MYOCARDIAL RELAXATION IN OLDER ADULTS
Authors: Angela Su-Mei Koh, Bryan Tan, Jun Liu, Ru San Tan, Fei Gao, Jean-Paul Kovalik, Jianhong Ching, See Hooi Ewe, Louis LY Tan, Siyong Yeo, Woon-puay Koh
Journal: Journal of the American College of Cardiology (2022)
Hospitalisations with infectious disease diagnoses in somatic healthcare between 1998 and 2019: A nationwide, register-based study in Swedish adults
Authors: Gustav Torisson, Mari Rosenqvist, Olle Melander, Fredrik Resman
Journal: The Lancet Regional Health - Europe (2022)

Several studies indicate increasing hospitalisation rates for specific infectious diseases (IDs). Studies describing the entire ID spectrum are scarcer. Our aim was to describe hospital use with ID diagnoses in Swedish adults from 1998 to 2019.All four-position codes in ICD-10 were reclassified as ID or non-ID diagnoses. Using data from the National Patient Register, age-standardised hospitalisation rates and average length-of-stay (LOS) was determined for hospitalisations with ID vs non-ID diagnoses in the primary position at discharge. The 22-year study period was divided into five periods that were compared using standardised rate ratios (SRR).Annual hospitalisations with ID diagnoses increased from 115 thousand in 1998-2002 to 182 thousand in 2015-2019, for a rate increase from 17·4 to 23.0 per 1000 person-years, and a SRR (95%CI) of 1.32 (1.32-1.33). Concurrently, the hospitalisation rate with non-ID diagnoses decreased from 147 to 110, for a SRR of 0.75 (0.75-0.75). Average LOS decreased less for IDs than for non-IDs. Consequently, the proportion of hospital nights for which an ID was considered causing the hospitalisation increased from 11% to 21%. Persons aged 80+ years had the highest ID hospitalisation rate.The increased hospital use with ID diagnoses suggests an increasing incidence of severe IDs as well as a changing case-mix of hospitalised patients. Given the anticipated demographic change, this trend is likely to persist. Healthcare systems will need to address IDs in a comprehensive and standardised way.Governmental Funding of Research within the Clinical Sciences (ALF).
Assessment of Machine Learning–Based Medical Directives to Expedite Care in Pediatric Emergency Medicine
Authors: Devin Singh, Sujay Nagaraj, Pouria Mashouri, Erik Drysdale, Jason Fischer, Anna Goldenberg, Michael Brudno
Journal: JAMA Network Open (2022)

Increased wait times and long lengths of stay in emergency departments (EDs) are associated with poor patient outcomes. Systems to improve ED efficiency would be useful. Specifically, minimizing the time to diagnosis by developing novel workflows that expedite test ordering can help accelerate clinical decision-making.
Metabo-Endotypes of Asthma Reveal Differences in Lung Function: Discovery and Validation in Two TOPMed Cohorts
Authors: Rachel S. Kelly, Kevin M. Mendez, Mengna Huang, Brian D. Hobbs, Clary B. Clish, Robert Gerszten, Michael H. Cho, Craig E. Wheelock, Michael J. McGeachie, Su H. Chu, Juan C. Celedón, Scott T. Weiss, Jessica Lasky-Su
Journal: American Journal of Respiratory and Critical Care Medicine (2021)

Rationale: Current guidelines do not sufficiently capture the heterogeneous nature of asthma; a more detailed molecular classification is needed. Metabolomics represents a novel and compelling approach to derive asthma endotypes (i.e., subtypes defined by functional and/or pathobiological mechanisms). Objectives: To validate metabolomic-driven endotypes of asthma and explore their underlying biology. Methods: In the Genetics of Asthma in Costa Rica Study (GACRS), untargeted metabolomic profiling, similarity network fusion, and spectral clustering was used to identify metabo-endotypes of asthma, and differences in asthma-relevant phenotypes across these metabo-endotypes were explored. The metabo-endotypes were recapitulated in the Childhood Asthma Management Program (CAMP), and clinical differences were determined. Metabolomic drivers of metabo-endotype membership were investigated by meta-analyzing findings from GACRS and CAMP. Measurements and Main Results: Five metabo-endotypes were identified in GACRS with significant differences in asthma-relevant phenotypes, including prebronchodilator (p-ANOVA = 8.3 × 10−5) and postbronchodilator (p-ANOVA = 1.8 × 10−5) FEV1/FVC. These differences were validated in the recapitulated metabo-endotypes in CAMP. Cholesterol esters, trigylcerides, and fatty acids were among the most important drivers of metabo-endotype membership. The findings suggest dysregulation of pulmonary surfactant homeostasis may play a role in asthma severity. Conclusions: Clinically meaningful endotypes may be derived and validated using metabolomic data. Interrogating the drivers of these metabo-endotypes has the potential to help understand their pathophysiology.
Myocarditis Following a Third BNT162b2 Vaccination Dose in Military Recruits in Israel
Authors: Limor Friedensohn, Dan Levin, Maggie Fadlon-Derai, Liron Gershovitz, Noam Fink, Elon Glassberg, Barak Gordon
Journal: JAMA (2022)

Prevalence of Clinical and Subclinical Myocarditis in Competitive Athletes With Recent SARS-CoV-2 Infection
AI-BASED GATED NON-CONTRAST CARDIAC CT MID-DIASTOLIC VOLUME ANALYSES COMPARED TO MULTI-PHASE GATED, CONTRAST CT
Authors: Ola Abdelkarim, Athira J. Jacob, Salma Zook, Myra Cocker, Prantik Gupta, Juan R. Giraldo, Diana Tran, Max Schoebinger, Chris Schwemmer, Mehmet A. Gulsun, Puneet Sharma, Saikiran Rapaka, Su Min Chang
Journal: Journal of the American College of Cardiology (2022)
21P Transcriptomic mapping of integrins and immune activation in high-grade serous ovarian cancer
Authors: K.I. Rojas Laimito, A. Ocana Fernandez, M.V. Villena, J.L. Gonzalez Larriba, J. Puente Vásquez, M.J. Rubio, H. García-Martínez, J. Garcia-Donas, L. Manso Sánchez
Journal: Annals of Oncology (2022)
Early Postoperative Supplementary Parenteral Nutrition
Authors: Olle Ljungqvist, Ulf O. Gustafsson, Dileep N. Lobo
Journal: JAMA Surgery (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
HSR22-153: Real-World Time to Discontinuation of First-Line Venetoclax + Obinutuzumab in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Authors: Xiaoxiao Lu, Qing Huang, Linda Wu, Bruno Emond, Shaun P. Forbes, Annalise Hilts, Stephanie Liu, Marie-Hélène Lafeuille, Patrick Lefebvre, Kerry A. Rogers
Journal: Journal of the National Comprehensive Cancer Network (2022)

"HSR22-153: Real-World Time to Discontinuation of First-Line Venetoclax + Obinutuzumab in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma" published on 31 Mar 2022 by National Comprehensive Cancer Network.
OUTCOMES FROM EARLY INITIATION OF MECHANICAL CIRCULATORY SUPPORT IN NON-ACUTE MYOCARDIAL INFARCTION RELATED CARDIOGENIC SHOCK-AN ANALYSIS OF THE NATIONAL INPATIENT SAMPLE DATABASE (2015-2018)
Authors: Varun Victor, Samarthkumar Thakkar, Kirolos Barssoum, Harsh P. Patel, Ahmed Mohamed, Rohan Desai, Mohab Hassib, Sidakpal Panaich, Wissam Khalife
Journal: Journal of the American College of Cardiology (2022)
Axonal Length Determines Distinct Homeostatic Phenotypes in Human iPSC Derived Motor Neurons on a Bioengineered Platform
Authors: Cathleen Hagemann, Carmen Moreno Gonzalez, Ludovica Guetta, Giulia Tyzack, Ciro Chiappini, Andrea Legati, Rickie Patani, Andrea Serio
Journal: Advanced Healthcare Materials (2022)

Abstract Stem cell‐based experimental platforms for neuroscience can effectively model key mechanistic aspects of human development and disease. However, conventional culture systems often overlook the engineering constraints that cells face in vivo. This is particularly relevant for neurons covering long range connections such as spinal motor neurons (MNs). Their axons extend up to 1m in length and require a complex interplay of mechanisms to maintain cellular homeostasis. However, shorter axons in conventional cultures may not faithfully capture important aspects of their longer counterparts. Here this issue is directly addressed by establishing a bioengineered platform to assemble arrays of human axons ranging from micrometers to centimeters, which allows systematic investigation of the effects of length on human axonas for the first time. This approach reveales a link between length and metabolism in human MNs in vitro, where axons above a “threshold” size induce specific molecular adaptations in cytoskeleton composition, functional properties, local translation, and mitochondrial homeostasis. The findings specifically demonstrate the existence of a length‐dependent mechanism that switches homeostatic processes within human MNs. The findings have critical implications for in vitro modeling of several neurodegenerative disorders and reinforce the importance of modeling cell shape and biophysical constraints with fidelity and precision in vitro.
MATERNAL AND FETAL OUTCOME OF PREGNANCY IN WOMEN WITH D TRANSPOSITION (D-TGA) OF THE GREAT ARTERIES AFTER ATRIAL AND ARTERIAL SWITCH OPERATIONS
Authors: Jena Pizula, Justin Devera, Tien M.H. Ng, Anilkumar O. Mehra, Uri Elkayam
Journal: Journal of the American College of Cardiology (2022)
Disincentives for vaccine refusal
Authors: Mun-Keat Looi
Journal: BMJ (2022)

As the world adjusts to living with covid-19 and its variants such as omicron, the need to boost vaccination rates is paramount.Some countries are attempting to force the hand of people who are less willing to be vaccinated by pivoting from incentives to disincentives.Perhaps the most major disincentives are vaccine mandates, curbing the ability of anyone unvaccinated to move freely in public spaces or to access public services.But, as with the plethora of rewards for vaccination, it remains to be seen whether these have the desired effect.Some experts have warned that, conversely, the heavy-handedness risks alienating and polarising these pockets of the populace for good.
<i>JAMA Network Open—</i>The Year in Review, 2021
Authors: Frederick P. Rivara, Stephan D. Fihn
Journal: JAMA Network Open (2022)

Last year when we wrote in our 2020 year in review 1 about how the pandemic had upended everyone's lives, we were hopeful that the pandemic might soon be brought under control with the advent of very effective vaccines and a year of rapid-paced learning on how to reduce risk of severe illness and death.Unfortunately, but perhaps not altogether unexpectedly, the frustratingly rapid adaptability of this pathogen, combined with the unpredictability of human behavior, made SARS-CoV-2 one of the dominant topics for health and health care again in 2021.Another theme that was woven into many of the manuscripts submitted to JAMA Network Open and those we published was the effect of systemic racism on health and health care.In recognition of growing importance of this topic in medicine and society, the editors of the journal engaged in a year-long process to examine how we could more effectively address this issue.Among several outcomes of these discussions was an editorial 2 outlining our views and plans for the future.In addition, we revised our mission statement: "The mission of JAMA Network Open is to improve health, health care, and health equity worldwide through open access dissemination of high quality, innovative, general medical research and commentary by and for a broad range of clinicians, researchers, policy makers, and public health and health care leaders."The journal had issued a call for articles in August 2020 on the prevention and effects of systematic racism on health 3 and has continued to contribute to this scientific discussion with more than 300 studies and commentaries
Leveraging Spaceflight to Advance Cardiovascular Research on Earth
Authors: Jessica M. Scott, Jana Stoudemire, Lianne Dolan, Meghan Downs
Journal: Circulation Research (2022)

The direct (eg, radiation, microgravity) and indirect (eg, lifestyle perturbations) effects of spaceflight extend across multiple systems resulting in whole-organism cardiovascular deconditioning. For over 50 years, National Aeronautics and Space Administration has continually enhanced a countermeasures program designed to characterize and offset the adverse cardiovascular consequences of spaceflight. In this review, we provide a historical overview of research evaluating the effects of spaceflight on cardiovascular health in astronauts and outline mechanisms underpinning spaceflight-related cardiovascular alterations. We also discuss how spaceflight could be leveraged for aging, industry, and model systems such as human induced pluripotent stem cell–derived cardiomyocytes, organoid, and organ-on-a-chip technologies. Finally, we outline the increasing opportunities for scientists and clinicians to engage in cardiovascular research in space and on Earth.
A COST COMPARISON OF ATRIAL FIBRILLATION MONITORING AFTER ISCHEMIC STROKE USING AN INSERTABLE CARDIAC MONITOR VERSUS WEARABLE MONITOR
Authors: Joseph Banno, Sarah Rosemas, Alfred Albano, Michael P. Brunner, Musa Dahu, Sanjay Dandamudi, Darryl Elmouchi, Muhib Khan, Wassim Jawad, Jiangyong Min, Andre J. Gauri, Nagib T. Chalfoun
Journal: Journal of the American College of Cardiology (2022)
CONVERGENT PROCEDURE COMPARED TO CATHETER ABLATION FOR LONGSTANDING PERSISTENT ATRIAL FIBRILLATION. A SUBGROUP META-ANALYSIS
Authors: Arafat Farooqui, Haris Bilal, Naira Saleem, Sanjay Maheshwari, Syed Mohammad Mazhar Uddin, Vijay Shetty, Gerald Hollander, Jacob Shani
Journal: Journal of the American College of Cardiology (2022)
A RETROSPECTIVE ANALYSIS COMPARING CATHETER DIRECTED THROMBOLYSIS VERSUS PERCUTANEOUS ASPIRATION THROMBECTOMY IN PATIENTS WITH ACUTE SUB-MASSIVE CENTRAL PULMONARY EMBOLISM
Authors: Akarsh Parekh, Anila Rao, Ryan Malek, Zeinab A. Saghir, Mark A. Zainea
Journal: Journal of the American College of Cardiology (2022)
BAIL-OUT ANTEGRADE TRANSSEPTAL TRANSCATHETER AORTIC VALVEREPLACEMENT IN STENOTIC DEGENERATIVE BIOPROSTHETIC AORTIC VALVE
Authors: Linle Hou, Parth Patel, Bruce Rutkin, Loukas S. Boutis, Alexander Lee, Avneet Singh
Journal: Journal of the American College of Cardiology (2022)
The route of SARS-CoV-2 to brain infection: have we been barking up the wrong tree?
Authors: Rafal Butowt, Christopher S. von Bartheld
Journal: Molecular Neurodegeneration (2022)

This letter draws attention to recent work supporting the notion that the SARS-CoV-2 virus may use the nervus terminalis rather than the olfactory nerve as a shortcut route from the nasal cavity to infect the brain.
THE DIAGNOSTIC PERFORMANCE OF QFR AND MYOCARDIAL PERFUSION IMAGING IN PATIENTS WITH PRIOR CORONARY ARTERY DISEASE.
Authors: Pepijn Van Diemen, Ruben Willem De Winter, Stefan Schumacher, Henk Everaars, Michiel Bom, Ruurt Jukema, Yvemarie Somsen, Pieter Raijmakers, Rolf A. Kooistra, Janny Timmer, Teemu Maaniitty, Lourens FHJ Robbers, Bob von Bartheld, Ahmet Demirkiran, Albert van Rossum, Johan H.C. Reiber, Juhani M. Knuuti, Stephen Richard Underwood, Eike C. Nagel, Paul Knaapen, Roel Driessen, Ibrahim Danad
Journal: Journal of the American College of Cardiology (2022)
Sprayable nanomicelle hydrogels and inflammatory bowel disease patient cell chips for development of intestinal lesion-specific therapy
Authors: Hyo-Jin Yoon, Songhyun Lee, Tae Young Kim, Seung Eun Yu, Hye-Seon Kim, Young Shin Chung, Seyong Chung, Suji Park, Yong Cheol Shin, Eun Kyung Wang, Jihye Noh, Hyun Jung Kim, Cheol Ryong Ku, Hong Koh, Chang-Soo Kim, Joon-Sang Park, Young Min Shin, Hak-Joon Sung
Journal: Bioactive Materials (2022)
BI-VENTRICULAR-ARTERIAL COUPLING FUNCTION IN LATINOS WITH HFPEF AND SUBDIASTOLIC DYSFUNCTION
Authors: Marko Novakovic, Jorge E. Silva Enciso, Mohammad Hashim Mustehsan, Katrina Swett, Ayana April-Sanders, Robert Kaplan, Sanjiv Jayendra Shah, Carlos Jose Rodriguez
Journal: Journal of the American College of Cardiology (2022)
COVID-19 Vaccine Provider Access and Vaccination Coverage Among Children Aged 5–11 Years — United States, November 2021–January 2022
Authors: Christine Kim, Randy Yee, Roma Bhatkoti, David Carranza, Danielle Henderson, Sachiko A. Kuwabara, James Phillip Trinidad, Sandra Radesky, Allen Cohen, Tara M. Vogt, Zachary Smith, Chris Duggar, Kevin Chatham-Stephens, Christina Ottis, Krista Rand, Travis Lim, Alice F. Jackson, Donald Richardson, Aaron Jaffe, Rachael Lubitz, Ryan Hayes, Aran Zouela, Deborah L. Kotulich, Patrick N. Kelleher, Angela Guo, Satish K. Pillai, Anita Patel
Journal: MMWR Morbidity and Mortality Weekly Report (2022)

On October 29, 2021, the Pfizer-BioNTech pediatric COVID-19 vaccine received Emergency Use Authorization for children aged 5-11 years in the United States.† For a successful immunization program, both access to and uptake of the vaccine are needed. Fifteen million doses were initially made available to pediatric providers to ensure the broadest possible access for the estimated 28 million eligible children aged 5-11 years, especially those in high social vulnerability index (SVI)§ communities. Initial supply was strategically distributed to maximize vaccination opportunities for U.S. children aged 5-11 years. COVID-19 vaccination coverage among persons aged 12-17 years has lagged (1), and vaccine confidence has been identified as a concern among parents and caregivers (2). Therefore, COVID-19 provider access and early vaccination coverage among children aged 5-11 years in high and low SVI communities were examined during November 1, 2021-January 18, 2022. As of November 29, 2021 (4 weeks after program launch), 38,732 providers were enrolled, and 92% of U.S. children aged 5-11 years lived within 5 miles of an active provider. As of January 18, 2022 (11 weeks after program launch), 39,786 providers had administered 13.3 million doses. First dose coverage at 4 weeks after launch was 15.0% (10.5% and 17.5% in high and low SVI areas, respectively; rate ratio [RR] = 0.68; 95% CI = 0.60-0.78), and at 11 weeks was 27.7% (21.2% and 29.0% in high and low SVI areas, respectively; RR = 0.76; 95% CI = 0.68-0.84). Overall series completion at 11 weeks after launch was 19.1% (13.7% and 21.7% in high and low SVI areas, respectively; RR = 0.67; 95% CI = 0.58-0.77). Pharmacies administered 46.4% of doses to this age group, including 48.7% of doses in high SVI areas and 44.4% in low SVI areas. Although COVID-19 vaccination coverage rates were low, particularly in high SVI areas, first dose coverage improved over time. Additional outreach is critical, especially in high SVI areas, to improve vaccine confidence and increase coverage rates among children aged 5-11 years.
TREATMENT AND OUTCOMES OF ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION (STEMI) AMONG HOSPITALIZED FRAIL PATIENTS IN THE UNITED STATES
Authors: Muni Rubens, Sandra Chaparro, Anshul Saxena, Juan Gabriel Ruiz-Pelaez, Juan Carlos Zevallos, Javier Jimenez
Journal: Journal of the American College of Cardiology (2022)
SUSPECTED ETIOLOGIES OF CONSTRICTIVE PERICARDITIS: A CASE REPORT OF POST-PERICARDIOTOMY SYNDROME
Authors: Alejandro Sanchez, Radhika Neicheril, Antonio Lewis, Manojna Nimmagadda, Jose Sleiman, Andres Sanchez Nadales, Stephanie Sleiman, Howard S. Bush, Gian Mendez Novaro
Journal: Journal of the American College of Cardiology (2022)