tbuckley/cabot-search huggingface dataset:
JAM-C Expression as a Biomarker to Predict Outcome of Patients with Acute Myeloid Leukemia—Response
Authors: Maria De Grandis, Stéphane J.C. Mancini, Norbert Vey, Michel Aurrand-Lions
Journal: Cancer Research (2018)

Acute myeloid leukemia (AML) is a heterogenous disease affecting essentially patients older than 55. Although most patients experience complete remission after intensive chemotherapy, the disease remains of dismal prognosis with long-term overall survival (OS) below 40% ([1][1]). Therefore, there is
Abstract 16632: Clinical Characteristics and In-Hospital Outcomes of Covid-19 Patients With Ecg St Segment Elevation: A System Wide Analysis
Authors: Avneet SINGH, Perwaiz Meraj, Arvind Reddy, Eitezaz Mahmood, Ibrahim Ali, Sriya Avadhani, Stavros Mountantonakis, Puneet Gandotra, Lawrence Ong, Luis Gruberg, rajiv jauhar
Journal: Circulation (2020)

Myocardial injury is seen in approximately 20% of COVID-19 patients and ST elevation myocardial infarction may be the presenting clinical manifestation. Recent data suggest that the ST-segment elevation (STE) may be due to myopericarditis. We assessed the clinical characteristics, electrocardiographic patterns, incidence, management and outcomes of COVID-19 pts with STE. Methods: We analyzed 23,406 ECGs (10,018 pts) admitted to 13 New York City area hospitals between March 1 and April 30, 2020. Results: After manual adjudication, 51 (0.5%) had focal STE, 22 (0.2%) had diffuse STE and 9,945 did not have STE. Baseline clinical characteristics were similar among the three groups, albeit a higher percentage of pts with low ejection fraction in the diffuse STE group. Cardiac catheterization was performed on 10 pts. Three pts did not have obstructive disease. Pts with focal STE were more likely to require inotropes and die during index hospitalization. Kaplan-Meier estimated overall survival rates were 31%, 33% and 6% in patients without STE, focal and diffuse STE, respectively (p &lt; 0.0001) (Figure). By stepwise logistic regression analysis, focal STE was the strongest predictor of death (OR=7.0; CI 3.8-13.0, p&lt;0 .0001) followed by age &gt; 65 years (OR=3.5; CI 3.1-3.9; p&lt;0.0001) and diffuse STE (OR=2.9; CI 1.1-7.2; p&lt;0.0001). Female gender was associated with a decreased risk (OR 0.72; CI, 0.65-0.79; p&lt;0.0001). Conclusions: In this large retrospective analysis of 10,018 COVID-19 pts, we observed that: 1) a very small percentage (0.7%) presented with STE; 2) 70% had focal STE and 30% had diffuse STE; 3) a minority underwent coronary angiography; 4) in-hospital mortality rates were very high for pts with STE, and even more so for those with focal STE (63% vs 46%) and; 5) focal STE was the strongest predictor of in-hospital mortality and female gender was a predictor of survival.
ACCF/SCCT/ACR/AHA/ASE/ASNC/NASCI/SCAI/SCMR 2010 Appropriate Use Criteria for Cardiac Computed Tomography
Authors: Allen J. Taylor, Manuel Cerqueira, John McB. Hodgson, Daniel Mark, James Min, Patrick O'Gara, Geoffrey D. Rubin
Journal: Journal of the American College of Cardiology (2010)
Cardiovascular responses to exercise. Effects of aging and exercise training in healthy men.
Authors: J RStratton, W CLevy, M DCerqueira, R SSchwartz, I BAbrass
Journal: Circulation (1994)

BACKGROUNDCardiac aging alters many of the acute responses to exercise stress, but the extent to which chronic exercise (ie, training) can alter or improve the effects of aging in humans is largely unknown.METHODS AND RESULTSCardiovascular responses to graded supine exercise stress (beginning at 200 kpm and increasing by 200 kpm every 3 minutes till exhaustion) were assessed using radionuclide ventriculography in 13 older (age, 60 to 82 years) and 11 young (age, 24 to 32 years) rigorously screened healthy men before and after 6 months of endurance training. Repeated-measures ANOVA was used to test significance. During exercise, the old group had a lesser increase in heart rate (+105% old versus +166% young), a greater increase in mean blood pressure (+35% old versus +22% young), lesser increases in ejection fraction (+3 ejection fraction units old versus +11 units young) and peak ejection rate (+62% old versus +119% young), a greater increase in end-diastolic volume index (+8% old versus -10% young), a le...
Inspecting the Glass Half-Full Identifies Strengths in the Development of Children With Autism Spectrum Disorder
Authors: Matthew J. Hollocks, Emily Simonoff
Journal: JAMA Network Open (2021)

Peter Szatmari, MD; Katherine Tombeau Cost, PhD; Eric Duku, PhD; Teresa Bennett, MD, PhD; Mayada Elsabbagh, PhD; Stelios Georgiades, PhD; Connor M. Kerns, PhD; Pat Mirenda, PhD; Isabel M. Smith, PhD; Wendy J. Ungar, PhD; Tracy Vaillancourt, PhD; Charlotte Waddell, MD; Anat Zaidman-Zait, PhD; Lonnie Zwaigenbaum, MD
Ischemia and reperfusion-induced arrhythmias in the rat. Effects of xanthine oxidase inhibition with allopurinol.
Authors: A SManning, D JColtart, D JHearse
Journal: Circulation Research (1984)

We have investigated the possibility that xanthine oxidase-linked free radical production has a role in the genesis of arrhythmias during ischemia and reperfusion. In this study, rats were treated with allopurinol (20 mg/kg, orally, 24 hours before study, plus 20 mg/kg, iv, 15 minutes prior to study). Using an anesthetized open-chest preparation with either coronary artery occlusion for 30 minutes, or 5 minutes followed by 10 minutes reperfusion, we monitored and compared the rhythm disturbances in experimental vs. placebo-treated rats (n = 18 in each group). Allopurinol treatment reduced the incidence of ventricular tachycardia during ischemia from 88% to 50% (P less than 0.05) and the number of premature ventricular complexes from 471 +/- 120 to 116 +/- 46 (P less than 0.02), but the treatment had no effect upon the incidence or duration of ventricular fibrillation or upon mortality. In contrast, far more dramatic protection was observed during reperfusion after 5 minutes of ischemia. Allopurinol treatm...
Circadian variation of exercise capacity in patients with Prinzmetal's variant angina: role of exercise-induced coronary arterial spasm.
Authors: HYasue, SOmote, ATakizawa, MNagao, KMiwa, STanaka
Journal: Circulation (1979)

Thirteen patients with Prinzmetal's variant angina performed treadmill exercise tests in the early morning and in the afternoon of the same day. The attacks with ST elevation were induced repeatedly in all 13 patients in the early morning, but in only two patients in the afternoon. Propranolol did not suppress the exercise-induced attacks in all 13 patients. Diltiazem suppressed the attacks in all 13 patients and phentolamine in eight of the nine patients. Coronary arteriograms demonstrated that spasm occluding completely or almost completely the large coronary artery supplying the area of myocardium showing ST elevation appeared during the attacks and disappeared along with the attacks after nitroglycerin administration in all four patients in whom the attacks were induced by arm exercise in the catheterization laboratory. We conclude that there is circadian variation of exercise capacity in patients with Prinzmetal's variant angina caused by coronary arterial spasm induced by exercise in the early morni...
Effects of verapamil on myocardial performance in coronary disease.
Authors: JFerlinz, J LEasthope, W SAronow
Journal: Circulation (1979)

Verapamil, a calcium antagonist, has been used extensively for treatment of cardiac arrhythmias. Concern persists, however, that it may seriously depress myocardial function in cardiac patients. To investigate this possibility, 20 patients with coronary artery disease (CAD) but no heart failure were given intravenous verapamil (0.1 mg/kg bolus, followed by 0.005 mg/kg/min infusion), and studied hemodynamically and angiographically. Verapamil markedly lowered mean aortic pressure (94 +/- 17 to 82 +/- 13 mm Hg, p less than 0.0005) and systemic vascular resistance (1413 +/- 429 to 1069 +/- 235 dyn-sec-cm5, p less than 0.0005). Simultaneously, all indices of left ventricular (LV) performance greatly improved: cardiac index rose from 2.8 +/- 0.6 to 3.1 +/- 0.7 1/min/m2 (p less than 0.0005), mean velocity of circumferential fiber shortening increased from 0.85 +/- 0.39 to 0.97 +/- 0.46 circ/sec (p less than 0.01), and ejection fraction improved from 55 +/- 16 to 61 +/- 18% (p less than 0.01). No significant cha...
Quantitation of left ventricular myocardial fiber hypertrophy and interstitial tissue in human hearts with chronically increased volume and pressure overload.
Authors: VFuster, M ADanielson, R ARobb, J CBroadbent, A LBrown, L RElveback
Journal: Circulation (1977)

Using new techniques, we quantitated left ventricular myocardial fiber hypertrophy and interstitial tissue in four groups of autopsied hearts free of coronary disease: 1) 22 normal hearts, 2) 20 hearts from patients with mitral incompetence (NYHA Class II-III) who died early after mitral valve replacement from causes other than cardiac failure, 3) 22 hearts from patients with mitral incompetence (NYHA Class III-IV) who died early after mitral valve replacement from cardiac failure with low cardiac output syndrome, and 4) 22 hearts from patients with hypertensive heart disease (NYHA Class II-III). Myocardial fiber hypertrophy was quantitated by measuring cross-sectional myocardial fiber diameter; the proportion of interstitial tissue was quantitated by using a computerized, high-resolution video image-digitizing system. Myocardial fiber average diameter in groups 2, 3 and 4 was significantly higher than group 1. The proportion of interstitial tissue was significantly increased in group 3. In chronic mitral...
Adrenergic coronary tone during submaximal exercise in the dog is produced by circulating catecholamines. Evidence for adrenergic denervation supersensitivity in the myocardium but not in coronary vessels.
Authors: W MChilian, D GHarrison, C WHaws, W DSnyder, M LMarcus
Journal: Circulation Research (1986)

The goal of this study was to test the hypothesis that circulating catecholamines are primarily responsible for alpha-adrenergic coronary vasoconstriction during submaximal exercise. The experimental series consisted of chronic studies in which a regional left ventricular sympathectomy was performed with phenol. Myocardial perfusion to the innervated and sympathectomized left ventricular regions was measured in these animals during (1) a control period, (2) treadmill exercise, (3) exercise during beta-adrenergic blockade, and (4) exercise during combined alpha- + beta-adrenergic blockade. We found no differences in myocardial perfusion between the innervated and sympathectomized regions or the transmural distribution of perfusion during any of these interventions. Thus, there is no evidence for neurogenic alpha-adrenergic coronary vasoconstriction. However, during exercise in the presence of alpha- and beta-blockade, coronary resistance (mmHg X min X 100 g/ml) was significantly less in both the innervated...
The Slippery Knot Syndrome
Authors: Thomas J. Foley
Journal: JAMA (1976)

<h3>To the Editor.—</h3> The new suture materials, particularly those coated with the lubricant silicone, or the nonsticking agent Teflon, are almost perfect. They have amazing tensile strength. The tissue reaction in most cases is almost nil. However, there is a disadvantage that is not well known<sup>1,2</sup>— the knots slip. This can be dangerous, as exemplified dramatically in the following case. <h3>Report of a Case.—</h3> A 60-year-old man walked into the emergency room because of left hip pain. A roentgenogram of the abdomen showed calcific rims of a large aortic abdominal aneurysm. He was taken to the operating room where a 9-cm, leaking aortic aneurysm was resected, including both iliac arteries. A knitted dacron prosthesis was sutured in place with continuous Polydek (braided Dacron partially impregnated and coated with Teflon [Deknatel Inc, Queens, NY]) six "0" suture. Three hours after surgery, the patient suddenly went into profound shock. At
Glucose tolerance during long term treatment with a somatostatin analogue.
Authors: L Verschoor, S W Lamberts, P Uitterlinden, E Del Pozo
Journal: BMJ (1986)

Seven patients with active acromegaly were treated with SMS 201-995, an analogue of somatostatin, for one year, the maximum dose being 100 micrograms three times a day. Three patients had impaired glucose tolerance before treatment, due to insulin resistance in two and insulin deficiency in one. In all patients treatment with the analogue slightly increased postprandial glucose concentrations and suppressed insulin concentrations for two to two and a half hours after each injection; growth hormone concentrations decreased progressively with treatment. The patient with impaired glucose tolerance due to insulin deficiency developed diabetes mellitus after four months' treatment; concomitant treatment with glibenclamide resulted in a decreased glucose concentration and increased insulin concentration. This analogue of somatostatin had only minor side effects on glucose tolerance in patients with acromegaly and may be used in patients with impaired glucose tolerance provided that glucose concentrations are monitored closely.
The reliability of intermittent ECG sampling in arrhythmia detection.
Authors: LRydén, AWaldenström, SHomberg
Journal: Circulation (1975)

Although intermittent ECG sampling is a commonly used method for arrhythmia detection there are no controlled studies of its efficiency. In the present study a continuous ECG was recorded for three hours in 52 patients with ventricular tachyarrhythmias. All ECGs were interpreted minute to minute to get the true arrhythmia content. Intermittent ECG samples were simulated by analyzing the first two and first five minutes of every 15 minutes in the ECG material. Two minute long ECG samples were also used every 30 minutes. The 15 and 30 minute long periods were classified as containing arrhythmias or not according to the arrhythmia content of the samples. These findings were subsequently compared with the true arrhythmia content. The arrhythmia detection rate depends on the sampling time and true arrhythmia occurrence. The distribution of arrhythmias within the periods was also of importance. With a five minute long ECG sample about 80% of the intervals containing any type of ventricular tachyarrhythmia will ...
Long-term responses of atrial rate and peripheral resistance to changes in ventricular pacing rate in awake dogs with atrioventricular block.
Authors: S JFisher, A MScher, C RWyss
Journal: Circulation Research (1984)

We wished to see if a maintained change in pressure at the baroreceptors leads to a maintained or a transient change in heart rate and total peripheral resistance, and if long-term changes in rate and resistance paralleled one another. In awake dogs with intact baroreceptors and complete atrioventricular block, ventricular rate was held alternately at high (90 beats/min) and low (50 beats/min) levels, each for 2 days. This cycle was repeated several times. Data were recorded for 1.5 hours each day. With this change in ventricular rate, there was a maintained change over 2 days in arterial (14.4 +/- 1.0 mm Hg) and central venous (3.0 +/- 1.2 mm Hg) pressures. These changes in pressure were accompanied by a maintained change in atrial rate of 41.1 +/- 9.4 beats/min; peripheral resistance, however, changed only transiently. In three animals, the half-cycle length was 1 week. Changes in heart rate also persisted for this period. It appears from these studies that there is long-term control of heart rate, but ...
Quantification of the normal Frank and McFee-Parungao orthogonal electrocardiogram at ages two to ten years.
Authors: J SKan, JLiebman, M HLee, AWhitney
Journal: Circulation (1977)

A quantification of the Frank and McFee-Parungao orthogonal electrocardiogram of 175 normal children, ages 2-10 years is presented. There are significant differences in age groups 2-5 and 6-10. The QRS voltages of the younger group demonstrate 1) greater Z anterior, 2) greater initial X right, 3) greater terminal X right, 4) smaller Y inferior, and 5) the T vector is oriented more posteriorly. There are significant differences between the two lead systems. 1) Frank spatial voltages are 70% of those of McFee. 2) Frank X left is 70% of McFee, but terminal X right is 75% and initial X right is 60% of McFee. 3) Frank Y inferior is 78% of McFee, but initial Y superior is 83% and terminal Y superior 61% of McFee. 4) Frank Z anterior is 64% and Frank Z posterior is 70% of McFee. 5) In terms of ratios the Frank is relatively less inferior, about equally posterior and more terminally right. 6) The T vector is more posterior in Frank than McFee.
Prevalence of Microscopic Colitis in Patients With Chronic Diarrhoea at a General District Hospital
Authors: Y Kassir, B Ayeboa-Sallah, R La Cava, A Yusuf
Journal: Endoscopy (2021)

Aims Microscopic Colitis (MC) is a cause of chronic, non-bloody diarrhoea and is characterised by endoscopically normal mucosa with characteristic histological findings. We aimed to investigate the prevalence of MC in patients investigated for chronic diarrhoea at a general district hospital.
Bowel Preparations Regimens for Colon Capsule Endoscopy – a Systematic Review and Meta-Analysis
Authors: T Bjoersum-Meyer, K Skonieczna-Zydecka, P Cortegoso Valdivia, I Stenfors, I Lutakov, E Rondonotti, M Pennazio, W Marlicz, G Baatrup, A Koulaouzidis, E Toth
Journal: Endoscopy (2021)

Aims Colon Capsule Endoscopy (CCE) is an alternative to colonoscopy in certain clinical settings. High completion rates (CR) and adequate colon cleanliness rates (ACR) are prerequisites if CCE is to be implemented as an equivalent diagnostic tool. To address this, we conducted a systematic review investigating the efficacy of different bowel preparation regimens on CR and ACR in CCE.
Time course of smooth muscle cell proliferation in the intima and media of arteries following experimental angioplasty.
Authors: HHanke, TStrohschneider, MOberhoff, EBetz, K RKarsch
Journal: Circulation Research (1990)

Smooth muscle cell (SMC) proliferation is known to be an important factor for the development of restenosis after percutaneous transluminal coronary angioplasty. To determine the time course of intimal and medial SMC proliferation and morphological changes after experimental angioplasty, an intimal atheroma was produced with repeated weak electrical stimulations in the right carotid artery of 45 male New Zealand White rabbits. Angioplasty was subsequently performed in 35 rabbits, and the proliferative responses were analyzed with histomorphological and immunohistological criteria at 3, 7, 14, 21, 28, and 42 days after intervention. A hemodynamic relevant stenosis after angioplasty was found in eight (23%) of 35 dilated arteries. In five rabbits the stenosis was due to a mural thrombus, and in three animals restenosis was caused by intimal SMC proliferation. In all dilated arteries the intimal wall thickness increased from 13 +/- 5 intimal cell layers (after electrical stimulation) to 33 +/- 14 cell layers...
13th Meeting of the Scientific Group on Methodologies for the Safety Evaluation of Chemicals (SGOMSEC): alternative testing methodologies for organ toxicity.
Authors: H Spielmann, N P Bochkov, L Costa, L Gribaldo, A Guillouzo, J J Heindel, M Karol, R Parchment, W Pfaller, P P Peraita, T Zacharewski
Journal: Environmental Health Perspectives (1998)

In the past decade in vitro tests have been developed that represent a range of anatomic structure from perfused whole organs to subcellular fractions. To assess the use of in vitro tests for toxicity testing, we describe and evaluate the current status of organotypic cultures for the major target organs of toxic agents. This includes liver, kidney, neural tissue, the hematopoietic system, the immune system, reproductive organs, and the endocrine system. The second part of this report reviews the application of in vitro culture systems to organ specific toxicity and evaluates the application of these systems both in industry for safety assessment and in government for regulatory purposes. Members of the working group (WG) felt that access to high-quality human material is essential for better use of in vitro organ and tissue cultures in the risk assessment process. Therefore, research should focus on improving culture techniques that will allow better preservation of human material. The WG felt that it is also important to develop and make available relevant reference compounds for toxicity assessment in each organ system, to organize and make available via the Internet complete in vivo toxicity data, including human data, containing dose, end points, and toxicokinetics. The WG also recommended that research should be supported to identify and to validate biological end points for target organ toxicity to be used in alternative toxicity testing strategies.
Echocardiography manifestations of flail aortic valve leaflets in bacterial endocarditis.
Authors: T MWray
Journal: Circulation (1975)

This report describes the echocardiographic features seen in a case of bacterial endocarditis in which the aortic valve leaflets had been partially destroyed. The endocardiogram demonstrated unusual, disorganized echo patterns in the outflow tract of the left ventricle near the anterior leaflet of the mitral valve in diastole. These were shown to be continuous with similar disorganized echo patterns demonstrated in the aortic root in diastole. These echocardiographic abnormalities were no longer present after aortic valve replacement.
Pneumatic Balloon Dilation for The Treatment Of Post-Fundoplication Symptoms: Long-Term Efficacy and Safety Results
Authors: P Gkolfakis, D Lorenzo, D Blero, H Louis, A Lemmers, M Arvanitakis, P Eisendrath, J Devière
Journal: Endoscopy (2021)

Aims Post-laparoscopic fundoplication (LF) dysphagia occurs in 5 %-17 % of patients and its optimal management remains questionable. We assessed the safety and efficacy of pneumatic dilation (PD) in patients with post-LF symptoms.
Effect of perfusion pressure distal to a coronary stenosis on transmural myocardial blood flow.
Authors: R JBache, J SSchwartz
Journal: Circulation (1982)

We tested the hypothesis that reductions of perfusion pressure distal to a flow-limiting coronary artery stenosis can directly impair perfusion of the subendocardial myocardium. Dogs were instrumented with an electromagnetic flowmeter probe and a variable occluder on the proximal left circumflex coronary artery. Coronary perfusion pressure was measured with a catheter distal to the occluder. Coronary autoregulation was abolished by intraarterial infusion of adenosine to produce maximal coronary vasodilation. The transmural distribution of myocardial blood flow was measured with radioactive microspheres during unimpeded arterial inflow, when the occluder was progressively narrowed to reduce distal coronary pressure to approximately 70%, 50% and 35% of the control coronary perfusion pressure, and during total coronary occlusion. Heart rate, left ventricular diastolic pressure and the fraction of coronary artery flow during systole remained constant throughout the study. Progressive reductions of coronary pe...