tbuckley/cabot-search huggingface dataset:
Preliminary Survey of Wearable Display Glasses for Medical Students in Endoscopy Room
Authors: KW Lee, HS Lee, JM Lee, HS Choi, ES Kim, B Keum, YT Jeen, HJ Chun
Journal: Endoscopy (2021)

Aims Several attempts have been made to incorporate smart glasses in the medical field. We decided to use wearable display glasses for endoscopy, particularly in the position of an observer, to compare the students’ response between the conventional method and the new method.
Migrated Esophageal Metal Stent – Protection Hood to the Rescue!
Authors: F Pereira Correia, G Alexandrino, F Bordalo Ferreira, R Carvalho, L Carvalho Lourenço, A Martins
Journal: Endoscopy (2021)

The protection hood is an accessory widely used in the removal of foreign bodies from the gastrointestinal tract. We present the case of a patient with esophageal neoplasm in which an esophageal stent was placed. Due to tumor shrinkage with chemotherapy, there was migration of the stent to the stomach. We decided to use the protection hood given the esophageal friability with a high risk of bleeding and perforation. In this way, we successfully and safely removed the stent. This case shows the potential of the protection hood in a clinical situation in which it is not frequently used.
Skeletal muscle metaboreceptor stimulation opposes peak metabolic vasodilation in humans.
Authors: LSinoway, SProphet
Journal: Circulation Research (1990)

The total blood flow requirements of a large muscle mass can exceed the maximal cardiac output generated by the heart during exercise. Therefore, to maintain blood pressure, muscle vasodilation must be opposed by sympathetic vasoconstriction. The primary neural signal that increases sympathetic outflow is unclear. In an effort to isolate the vasoconstricting mechanism that opposes vasodilation, we measured the peak forearm vascular conductance response after the release of 10 minutes of forearm circulatory arrest under five separate study conditions: 1) no leg exercise, 2) low-level supine leg exercise, 3) low-level supine leg exercise with leg circulatory arrest after exercise, 4) high-level supine leg exercise, and 5) high-level supine leg exercise with leg circulatory arrest after exercise. We found that both high-workload conditions reduced peak forearm conductance below the no-leg exercise condition (a 34% reduction during leg exercise and a 52% reduction during leg exercise followed by leg circulato...
Appropriate Treatment For Non-Pedunculated Colorectal Polyps &gt; 20 MM According To Western And Eastern Approach: Conditional Inference-Tree From A Prospective Multicenter Cohort
Authors: J da Costa-Seixas, M López-Cerón, A Arnau, Ò Rosiñol, M Cuatrecasas, A Herreros-de-Tejada, Á Ferrández, M Serra-Burriel, Ó Nogales, L de Castro, J López-Vicente, P Vega, MA Álvarez-González, JM González-Santiago, M Hernández-Conde, P Díez-Redondo, L Rivero-Sánchez, AZ Gimeno-García, A Burgos, FJ García-Alonso, M Bustamante-Balén, E Martínez-Bauer, B Peñas, D Rodríguez-Alcalde, M Pellisé, I Puig
Journal: Endoscopy (2021)

Aims To determine algorithms for choosing the suitable treatment in non-pedunculated colorectal lesions ≥20 mm assessed by Western endoscopists with NBI and without magnification.​​​​
New generation of DNA-based immunotherapy induces a potent immune response and increases the survival in different tumor models
Authors: Alessandra Lopes, Chiara Bastiancich, Mathilde Bausart, Sophie Ligot, Laure Lambricht, Kevin Vanvarenberg, Bernard Ucakar, Bernard Gallez, Véronique Préat, Gaëlle Vandermeulen
Journal: Journal for ImmunoTherapy of Cancer (2021)

Background Strategies to increase nucleic acid vaccine immunogenicity are needed to move towards clinical applications in oncology. In this study, we designed a new generation of DNA vaccines, encoding an engineered vesicular stomatitis virus glycoprotein as a carrier of foreign T cell tumor epitopes (plasmid to deliver T cell epitopes, pTOP). We hypothesized that pTOP could activate a more potent response compared with the traditional DNA-based immunotherapies, due to both the innate immune properties of the viral protein and the specific induction of CD4 and CD8 T cells targeting tumor antigens. This could improve the outcome in different tumor models, especially when the DNA-based immunotherapy is combined with a rational therapeutic strategy. Methods The ability of pTOP DNA vaccine to activate a specific CD4 and CD8 response and the antitumor efficacy were tested in a B16F10-OVA melanoma (subcutaneous model) and GL261 glioblastoma (subcutaneous and orthotopic models). Results In B16F10-OVA melanoma, pTOP promoted immune recognition by adequate processing of both MHC-I and MHC-II epitopes and had a higher antigen-specific cytotoxic T cell (CTL) killing activity. In a GL261 orthotopic glioblastoma, pTOP immunization prior to tumor debulking resulted in 78% durable remission and long-term survival and induced a decrease of the number of immunosuppressive cells and an increase of immunologically active CTLs in the brain. The combination of pTOP with immune checkpoint blockade or with tumor resection improved the survival of mice bearing, a subcutaneous melanoma or an orthotopic glioblastoma, respectively. Conclusions In this work, we showed that pTOP plasmids encoding an engineered vesicular stomatitis virus glycoprotein, and containing various foreign T cell tumor epitopes, successfully triggered innate immunity and effectively promoted immune recognition by adequate processing of both MHC-I and MHC-II epitopes. These results highlight the potential of DNA-based immunotherapies coding for viral proteins to induce potent and specific antitumor responses.
Low-molecular-weight heparin reduces neointimal proliferation after coronary stent implantation in hypercholesterolemic minipigs.
Authors: A BBuchwald, CUnterberg, KNebendahl, H JGröne, VWiegand
Journal: Circulation (1992)

BACKGROUNDIntracoronary stents have been suggested as a method of reducing the restenosis rate after balloon angioplasty. Proliferation of vascular smooth muscle cells is a major contributing factor to the restenosis process. Heparin and some of its derivatives have been shown to inhibit smooth muscle cell proliferation. We investigated the effect of low-molecular-weight heparin on the proliferative response after implantation of a balloon-expandable tantalum stent in previously deendothelialized coronary artery segments of hypercholesterolemic minipigs.METHODS AND RESULTSMinipigs were fed a diet containing 2% cholesterol, starting 1 month before balloon denudation of the endothelium in a coronary artery. One month later, a stent was implanted at this site. Animals were killed after 4 weeks (group 1, n = 6) or 3 months (group 2, n = 6). Animals in group 3 (n = 6), also followed for 4 weeks after stenting, received subcutaneous low-molecular-weight heparin at a dose of 200-300 units/kg anti-factor Xa activ...
Vasodilator therapy for chronic left ventricular failure.
Authors: R BKovick, J HTillisch, S CBerens, A DBramowitz, K IShine
Journal: Circulation (1976)

The effects of chronic oral vasodilator therapy were studied in a group of patients with refractory congestive heart failure. Fifteen patients were treated acutely with intravenous sodium nitroprusside and sublingual isosorbide dinitrate. After continuous therapy with nitroprusside and isosorbide dinitrate for up to 72 hours the patients were then placed on isosorbide dinitrate and oral phenoxybenzamine. Hemodynamic responses to nitroprusside, isosorbide dinitrate, and phenoxybenzamine with isosorbide dinitrate were determined. After a mean follow-up of seven months, nine patients who were receiving isosorbide dinitrate and phenoxybenzamine underwent repeat hemodynamic studies. Beneficial effects of acute vasodilator therapy included a significant reduction in pulmonary capillary wedge pressure and systemic vascular resistance, and significant increases in cardiac index and stroke work index. Mean arterial blood pressure and heart rate were unchanged. During the period of chronic vasodilator administratio...
Determinants of survival in patients with congestive cardiomyopathy: quantitative morphologic findings and left ventricular hemodynamics.
Authors: FSchwarz, GMall, HZebe, ESchmitzer, JManthey, HScheurlen, WKübler
Journal: Circulation (1984)

We analyzed data from 68 consecutive patients with congestive cardiomyopathy to evaluate the prognostic significance of quantitative morphologic findings in left ventricular myocardium as compared with the prognostic significance of left ventricular hemodynamics. Left ventricular endomyocardial biopsy specimens were obtained from all patients during diagnostic heart catheterization. Myocardial fiber diameter, volume fraction of interstitial fibrosis, and intracellular volume fraction of myofibrils were determined by light-microscopic morphometry. All patients had normal coronary arteriograms, but reduced left ventricular ejection fractions. There were 23 deaths during a mean follow-up period of 1124 days. Multivariate regression analysis (Cox model) revealed that left ventricular ejection fraction (p less than .00001) and left ventricular systolic pressure (p less than .01), but not morphometric findings in biopsy specimens, were independent predictors of cardiac death. Thus, morphologic findings in the l...
Arrhythmogenic influence of intracoronary thrombosis during acute myocardial ischemia.
Authors: J AGoldstein, M CButterfield, YOhnishi, T JShelton, P BCorr
Journal: Circulation (1994)

BACKGROUNDPatients with acute coronary artery thrombosis often develop primary malignant ventricular arrhythmias (MVA) early after coronary occlusion. In contrast, acute ischemia induced by nonthrombotic balloon occlusion during routine coronary angioplasty rarely elicits such arrhythmias. This study was designed to assess the role of intracoronary thrombosis in arrhythmogenesis during acute ischemia.METHODS AND RESULTSWe compared the incidence of MVA associated with acute left anterior descending coronary artery (LAD) thrombosis elicited in open-chest anesthetized dogs by electrical injury (n = 10) or intracoronary stent (n = 9) versus LAD balloon occlusion (n = 15). Compared with animals subjected to balloon occlusion, those with thrombotic occlusion had a significantly greater incidence of MVA, defined as nonsustained ventricular tachycardia (total duration > 10 seconds), sustained ventricular tachycardia, or ventricular fibrillation developing within the first 30 minutes of occlusion. In the combined ...
The role of hydralazine therapy for pulmonary arterial hypertension of unknown cause.
Authors: ELupi-Herrera, JSandoval, MSeoane, DBialostozky
Journal: Circulation (1982)

Hydralazine was administered acutely to 12 patients who had pulmonary arterial hypertension of unknown cause. All of the patients were studied at rest and nine during exercise. On the basis of hydralazine response at rest, the patients were divided in two groups. In six patients (group A), pulmonary arteriolar resistance (Rp) decreased from 8.4 +/- 1.4 to 4.8 +/- 1.4 U/m2 (p less than 0.001), cardiac index (CI) increased from 3.47 +/- 0.3 to 5.86 +/- 0.5 1/min/m2 (p less than 0.005) and systemic resistance (Rs) decreased from 25 +/- 4 to 14 +/- 2 U/m2 (p less than 0.01). The Rp/Rs ratio did not change significantly after hydralazine (0.32 +/- 0.03 vs 0.33 +/- 0.07, NS). In the other six patients (group B), Rs decreased from 25 +/- 2 to 17.0 +/- 1 U/m2 (p less than 0.01), but the other variables did not change significantly. Our results suggest that the pulmonary vasodilatory effect of hydralazine caused a marked reduction in right ventricular afterload in group A. In group B, a marked systemic vasodilator...
Block of IKs, the slow component of the delayed rectifier K+ current, by the diuretic agent indapamide in guinea pig myocytes.
Authors: JTurgeon, PDaleau, P BBennett, S SWiggins, LSelby, D MRoden
Journal: Circulation Research (1994)

There is a high incidence of diuretic use among patients who develop exaggerated QT prolongation and polymorphic ventricular tachycardia (torsade de pointes) during treatment with action potential-prolonging agents. Diuretic-induced hypokalemia is thought to be the usual mechanism, but a direct effect of diuretic drugs on repolarizing currents is an additional possibility. Therefore, in this study, we examined the effects of the diuretic agents chlorthalidone and indapamide on the cardiac delayed rectifier current. In guinea pig ventricular myocytes, this current is made up of two components: IKr, a rapidly activating, inwardly rectifying current blocked by most action potential-prolonging antiarrhythmics, and IKs, a slowly activating component. In this preparation, indapamide blocked outward current in a time-, voltage- and concentration-dependent fashion, whereas chlorthalidone (1 mmol/L) was without effect. The following features of the effect of indapamide strongly suggest selective block of IKs: (1) ...
In acute HF and iron deficiency, IV ferric carboxymaltose reduced HF hospitalizations, but not CV death, at 1 y
Authors: Ersilia M. DeFilippis, Harriette G.C. Van Spall
Journal: Annals of Internal Medicine (2021)

ACP Journal ClubApril 2021In acute HF and iron deficiency, IV ferric carboxymaltose reduced HF hospitalizations, but not CV death, at 1 yErsilia M. DeFilippis, MD, Harriette G.C. Van Spall, MD, MPHErsilia M. DeFilippis, MDColumbia University Irving Medical Center, New York, New York, USA (E.M.D.), Harriette G.C. Van Spall, MD, MPHMcMaster University, Hamilton, Ontario, Canada (H.G.V.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJ202104200-045 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationPonikowski P, Kirwan BA, Anker SD, et al. Lancet. 2020;396:1895-904. https://pubmed.ncbi.nlm.nih.gov/33197395Clinical Impact RatingsHospitalists: Cardiology: Hematology: References1 Okonko DO, Grzeslo A, Witkowski T, et al. Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency FERRIC-HF: a randomized, controlled, observer-blinded trial. J Am Coll Cardiol. 2008;51:103-12. [PMID: 18191732] Google Scholar2 Anker SD, Comin Colet J, Filippatos G, et al. Ferric carboxymaltose in patients with heart failure and iron deficiency. N Engl J Med. 2009;361:2436-48. [PMID: 19920054] Google Scholar Author, Article, and Disclosure InformationAffiliations: Columbia University Irving Medical Center, New York, New York, USA (E.M.D.)McMaster University, Hamilton, Ontario, Canada (H.G.V.)Disclosures: The commentators have disclosed no conflicts of interest. The forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M20-7315.This article was published at Annals.org on 6 April 2021. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCritical Care Management of Decompensated Right Heart Failure in Pulmonary Arterial Hypertension Patients – An Ongoing Approach April 2021Volume 174, Issue 4Page: JC45KeywordsCardiomyopathiesFerritinHeart failureHemoglobinHospitalizationsIntent to treat analysisIron deficiencyLeft ventricular ejection fractionMuscular dystrophiesRelative risk ePublished: 6 April 2021 Issue Published: April 2021 Copyright & PermissionsCopyright © 2021 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Endoscopic ultrasonography-guided pancreaticoduodenostomy with a lumen-apposing metal stent to treat main pancreatic duct dilatation
Authors: Masaki Kuwatani, Kosuke Nagai, Yunosuke Takishin, Ryutaro Furukawa, Hajime Hirata, Kazumichi Kawakubo, Naoya Sakamoto
Journal: Endoscopy (2021)

A 60-year-old woman was referred to our hospital for work-up of a mass in the pancreas with main pancreatic duct (MPD) dilatation. She had no symptoms, but had a history of abnormal glucose tolerance for 2 years. A contrast-enhanced computed tomography (CT) scan showed a low density mass with scattered contrast enhancement in the pancreatic head and dilatation of the distal MPD ([Fig. 1]). Endoscopic ultrasonography (EUS) revealed a multilocular cyst with microcysts in the area, which was compressing the MPD and causing the MPD dilatation ([Fig. 2]). The lesion was eventually diagnosed as a serous cystadenoma and was observed with regular imaging tests.
Abstract 16417: Role of Long Non-Coding RNAs in the Regulation of the Notch Pathway: Implication for Calcific Aortic Valve Stenosis
Authors: FayezHadji, MBoulanger, SandraGuauque-Olarte, RihabBouchareb, YohanBossé, PatrickMathieu
Journal: Circulation (2014)

Introduction: Calcific aortic valve stenosis (CAVS) is the most common valvular heart disease. The disease process is largely driven by an abnormal mineralization of leaflets. The Notch pathway is involved in the osteogenic transition of valve interstitial cells (VICs) and palys an important role in CAVS. However, the molecular processes involved in the regulation of Notch signaling in CAVS remain to be determined Hypothesis: Long non-coding RNAs (Long ncRNAs) may be involved in the control of the Notch pathway Methods: We analyzed the gene expression pattern of valvular tissues (controls and CAVS) using microarrays. Furthermore, we explored the role of a Long ncRNA on the mineralization of VICs. Signaling of the Notch pathway was investigated by promoter luciferase activity and by analyzing mRNA levels of target genes Results: A transcriptomic study revealed that a Long ncRNA is overexpressed in CAVS. This result was confirmed by q-PCR in a larger group of aortic valve tissues (n=152). Silencing and over...
Echocardiography diagnosis of ruptured aneurysm of sinus of Valsalva. Report of two cases.
Authors: MMatsumoto, HMatsuo, SBeppu, YYoshioka, YKawashima, YNimure
Journal: Circulation (1976)

Echocardiographic features of two cases of ruptured congenital aneurysm of Valsalva sinus with (case1) and without (case 2) a supracristal ventricular defect were studied before and after surgery by standard echocardiography. M-mode scan and two-dimensional echocardiography. Discontinuity was observed in the echo from the aneurysm wall of the Valsalva sinus in case 1 with ruptured aneurysm, but was not observed in a similar case of unruptured aneurysm. Herniation of the right coronary cusp of the aortic valve into the right ventricular outflow tract was also observed in case 1. After surgical correction the echo from the aneurysm wall and from the herniated right coronary cusp of the aortic valve disappeared. Discontinuity in the echo from the anterior aortic wall and the interventricular septum also disappeared. In case 2, discontinuity in the echo from the anterior aortic wall, and tricuspid flutter with an abnormally low early diastolic peak were observed. These abnormalities disappeared after surgery....
Membranous subaortic stenosis complicated by aneurysm of the membranous septum and mitral valve prolapse.
Authors: C CCaudill, S KKrueger, C SWilson, TRourke, D BPolicky, W FWeaver
Journal: Circulation (1976)

The clinical, echocardiographic, and catheterization findings in a patient with discrete subaortic stenosis, aneurysm of the membranous interventricular septum, and mitral valve prolapse are presented. Echocardiography showed a subaortic membrane, abnormal aortic valve motion, accentuated systolic anterior motion of the membranous interventricular septum, and prolapsing mitral leaflets. Cardiac catheterization confirmed the diagnoses. The possible functional interrelationship of these lesions is discussed.
Meet me halfway: Are in vitro 3D cancer models on the way to replace in vivo models for nanomedicine development?
Authors: Sabina Pozzi, Anna Scomparin, Sahar Israeli Dangoor, Daniel Rodriguez Ajamil, Paula Ofek, Lena Neufeld, Adva Krivitsky, Daniella Vaskovich-Koubi, Ron Kleiner, Pradip Dey, Shani Koshrovski-Michael, Noa Reisman, Ronit Satchi-Fainaro
Journal: Advanced Drug Delivery Reviews (2021)
Contractile shortening response of ventricular cells to extracellular acidosis. Evidence for two-site control of H+-Ca2+ interaction.
Authors: G ALanger, T LRich, SJi
Journal: Circulation Research (1989)

The effect of extracellular acidosis on contraction of single isolated ventricular cells from rabbit was measured in a system in which pHo could be changed in less than 200 msec. The contractile response to acidotic levels was complete within 25 seconds. The response was measured 30 seconds after pHo was decreased to 7.0, 6.5, 6.0, and 5.5 at each of 8 [Ca]o levels (0.125-4.0 mM). Cell shortening versus [Ca]o was plotted to construct a curve for each pHo level, with each point relative to shortening at pH 7.5, [Ca]o = 1 mM (100% value). Calcium current (1 mM [Ca]o) was also measured 30 seconds after pHo was decreased from 7.5 to 6.5 with single-cell patch clamp technique. The contractile response to extracellular acidosis is accurately predicted by assuming two (probably sarcolemmal) sites at which H+ ions affect calcium binding and/or flux: (equation; see text) The first factor represents a set of sites that are proposed to control access, dependent on the degree of their ionization, to sites represented...
25P Evaluation of PD-L1 and Ki67 markers in CTCs of NSCLC patients treated with pembrolizumab
Authors: M. Spiliotaki, H. Charalambous, C.M. Neophytou, G. Gregoriou, P. Vogazianos, C. Deltas, A.I. Constantinou
Journal: Journal of Thoracic Oncology (2021)
The effect of hypertension and left ventricular hypertrophy on the lower range of coronary autoregulation.
Authors: D GHarrison, M SFlorentine, L ABrooks, S MCooper, M LMarcus
Journal: Circulation (1988)

These studies were performed to test the hypothesis that left ventricular hypertrophy arising as a complication of chronic hypertension is associated with impaired coronary autoregulation. Twelve dogs with hypertension and left ventricular hypertrophy (one-kidney, one-clip model) and 11 normal dogs were instrumented and subsequently studied while conscious. Circumflex pressure, measured with an intracoronary catheter, was adjusted to 100, 75, and 40 mm Hg with a hydraulic occluder that was placed proximally. At each circumflex pressure, myocardial perfusion was measured with radioactive microspheres. Reduction of circumflex pressure over this range did not significantly alter heart rate, left atrial pressure, or arterial pressure. In normal dogs, reduction of circumflex pressure did not alter total myocardial perfusion or the transmural distribution of perfusion. In contrast, in dogs with hypertension and left ventricular hypertrophy, circumflex subendocardial perfusion decreased 46% when pressure was dec...
Comment on Duran et al. Introduction of IADPSG Criteria for the Screening and Diagnosis of Gestational Diabetes Mellitus Results in Improved Pregnancy Outcomes at a Lower Cost in a Large Cohort of Pregnant Women: The St. Carlos Gestational Diabetes Study. Diabetes Care 2014;37:2442–2450
Authors: Brandi Addison, L. Maria Belalcazar
Journal: Diabetes Care (2015)

We read with interest the article by Duran et al. (1) that showed an improvement in pregnancy outcomes and a reduction in health care costs with the implementation of the International Association of the Diabetes and Pregnancy Study Groups criteria (IADPSGC) for the diagnosis of gestational diabetes mellitus (GDM) when compared with the traditional Carpenter-Coustan (CC) criteria. The inclusion of women with a lesser degree of dysglycemia with the IADPSGC was associated with a more than threefold increase in the prevalence of GDM (11% with the CC criteria and 36% with the IADPSGC) and, importantly, with …