tbuckley/cabot-search huggingface dataset:
Dual Stenting: Eus Biliary Drainage And Duodenal Metal Stent
Authors: M Borahma, y Jebari, N Lagdali, I Benelbarhdadi, FZ Ajana
Journal: Endoscopy (2021)

A 57 old-year-male, with no medical history, was admitted for acute cholangitis. The clinical examination noted jaundice and scratching lesions. CT-scan showed a pancreatic head mass with upstream dilation of the common bile duct and intrahepatic duct. Abdominal-MRI showed the same findings as CT-scan and an infiltration of the duodenal wall. During endoscopic drainage, duodenoscopy showed a gastric outlet obstruction with complete stenosis of the duodenum, since, transpapillary drainage was impossible. we chose to perform a dual stenting: echoendoscopic drainage through choledochoduodenal anastomosis with a fully covered self-expanding metal stent 80/8 mm and placement of duodenal metal stent 80/20mm.
Malignant Hilar Biliary Strictures: Efficiency Of Endoscopic Drainage
Authors: M El Mountassir, M Borahma, N Lagdali, I Benelbarhdadi, FZ Ajana
Journal: Endoscopy (2021)

Aims The endoscopic drainage (ED) of malignant hilar biliary strictures (MHBS) is often a challenge for the endoscopist with a significant failure rate.Our objective was to evaluate the efficacy of (ED) in (MHBS).
Increased 68Ga-FAPI Uptake in Chronic Cholecystitis and Degenerative Osteophyte
Authors: Huipan Liu, Zan Chen, Xiao Yang, Wenhui Fu, Yue Chen
Journal: Clinical Nuclear Medicine (2021)

68Ga-FAPI PET/CT has been used in the evaluation of a variety of malignancies. An increasing number of case studies on FAPI uptake in nonmalignant diseases is also gaining support and enthusiasm. We present a case of asymptomatic chronic cholecystitis and degenerative osteophyte detected incidentally by 68Ga-FAPI PET/CT.
Abstract P399: Fasting Insulin Levels and Incidence of Hypertension, Stroke and Coronary Heart Disease: A Meta-analysis of Prospective Cohort Studies
Authors: Pengcheng Xun, Ying Wu, Qianchuan He, Ka He
Journal: Circulation (2013)

Background: Insulin resistance is a precursor of numerous chronic diseases including cardiovascular diseases (CVD). Fasting insulin level is a suggested surrogate of insulin resistance. However, a ...
Impact of the Implementation of the Dutch National fit-based CRC Screening Program on Incidence and Characteristics of Screen-Detected CRCS
Authors: ECH Breekveldt, I Lansdorp-Vogelaar, E Toes-Zoutendijk, MCW Spaander, AJ van Vuuren, FJ van Kemenade, C Ramakers, E Dekker, ID Nagtegaal, ME van Leerdam, MAG Elferink
Journal: Endoscopy (2021)

Aims Since 2014, a population-based colorectal cancer (CRC) screening program was stepwise implemented in the Netherlands, using biennial fecal immunochemical testing (FIT). As of 2019, the program was fully implemented, inviting all individuals aged between 55-75 years. This study assessed the impact of the implementation of a national FIT-based CRC screening program on different outcomes of CRC.
Role of right and left atria in natriuresis and atrial natriuretic factor release during blood volume changes in the conscious rat.
Authors: RGarcia, MCantin, GThibault
Journal: Circulation Research (1987)

This study investigated whether excision of either the right or left atrial appendage of rats alters their natriuretic response and the release of atrial natriuretic factor during acute blood volume expansion or reduction. These animals were subjected to a thoracotomy and either had their right or left atrial appendages removed or underwent a right or left atrial sham appendectomy for comparative, control purposes. Intrajugular vein, intracarotid artery, and intravesical catheters were installed 3-4 weeks later under sodium pentobarbital anesthesia. Then, when the rats were conscious, blood volume was expanded using blood from donor rats once every 15 minutes in 3 increments of 10% of the calculated total blood volume at a rate of 5 ml/kg/min. Blood and urine samples were collected before volume expansion and at the end of each 15-minute period, with the withdrawn blood being replaced. A maximal fourfold increase in urinary volume, urinary sodium excretion, and plasma atrial natriuretic factor was observe...
Comment on American Diabetes Association. <i>Standards of Medical Care in Diabetes—2017</i>. Diabetes Care 2017;40(Suppl. 1):S1–S135
Authors: David P. Sonne, Bianca Hemmingsen
Journal: Diabetes Care (2017)

Screening and early detection of hyperglycemia are among the cornerstones in the recent Standards of Medical Care in Diabetes—2017 published by the American Diabetes Association (ADA) (1), despite the debate as to their overall benefits (2,3). In fact, this year new tools have been added to the bag: an “ADA risk test” (4) to screen for intermediate hyperglycemia (designated “prediabetes” by the ADA) and type 2 diabetes (T2D). If intermediate hyperglycemia is identified, then at least annual monitoring for the development of T2D is recommended. The risk evaluation is based on an online questionnaire in which a person’s risk is calculated on the basis of age, sex, family history of T2D, activity level, and weight.

Unfortunately, this strategy overestimates the risk and leads to unnecessary worries and …
心筋梗塞後,緩徐な経過でしん出型心破裂を来し,CRP異常高値がその診断に有用であった一例
Authors: 小野敏嗣, 相沢健一, 中島敏明, 宇野漢成, 佐原真, 森田敏宏, 小野稔, 本村昇, 高本真一
Journal: Circulation (2004)
Use of the rabbit ear artery to serially assess foreign protein secretion after site-specific arterial gene transfer in vivo. Evidence that anatomic identification of successful gene transfer may underestimate the potential magnitude of transgene expression.
Authors: D WLosordo, J GPickering, STakeshita, GLeclerc, LWeir, MKearney, JJekanowski, J MIsner
Journal: Circulation (1994)

BACKGROUNDThe development of molecular strategies for the treatment of restenosis has been hindered by low efficiencies of in vivo arterial transfection. Expression of intracellular marker proteins is generally evident in < 1% of vascular smooth muscle cells after in vivo arterial transfection. Efforts to improve the efficiency of in vivo gene transfer have been further impeded by the use of transgenes encoding for intracellular marker proteins, necessitating tissue removal and limiting survey for expression to one point in time.METHODS AND RESULTSTo study gene expression on a serial basis in vivo and determine the relation between a secreted gene product and transfection efficiency after in vivo arterial gene transfer, a method for performing and serially monitoring gene expression in vivo was developed using the central artery of the rabbit ear. Liposome-mediated transfection of plasmid DNA containing the gene for human growth hormone (hGH) was successfully performed in 18 of 23 arteries. Serum hGH leve...
Relation between glycolysis and calcium homeostasis in postischemic myocardium.
Authors: R WJeremy, YKoretsune, EMarban, L CBecker
Journal: Circulation Research (1992)

This study examined the hypothesis that glycolysis is required for functional recovery of the myocardium during reperfusion by facilitating restoration of calcium homeostasis. [Ca2+]i was measured in isolated perfused rabbit hearts by using the Ca2+ indicator 1,2-bis(2-amino-5-fluorophenoxy)ethane-N,N,N',N'-tetraacetic acid (5F-BAPTA) and 19F nuclear magnetic resonance spectroscopy. In nonischemic control hearts, inhibition of glycolysis with iodoacetate did not alter [Ca2+]i. In hearts subjected to 20 minutes of global zero-flow ischemia, [Ca2+]i increased from 260 +/- 80 nM before ischemia to 556 +/- 44 nM after 15 minutes of ischemia (p less than 0.05). After reperfusion with 5 mM pyruvate as a carbon substrate, [Ca2+]i increased further in hearts with intact glycolysis to 851 +/- 134 nM (p less than 0.05 versus ischemia) during the first 10 minutes of reperfusion, before returning to preischemic levels. In contrast, inhibition of glycolysis during the reperfusion period resulted in persistent severe c...
The PDE-Opathies: Diverse Phenotypes Produced by a Functionally Related Multigene Family
Authors: Graeme B. Bolger
Journal: Trends in Genetics (2021)

The phosphodiesterase (PDE)-opathies, an expanding set of disorders caused by germline mutations in cyclic nucleotide PDEs, present an intriguing paradox. The enzymes encoded by the PDE family all hydrolyze cAMP and/or cGMP, but mutations in different family members produce very divergent phenotypes. Three interacting factors have been shown recently to contribute to this phenotypic diversity: (i) the 21 genes encode over 80 different isoforms, using alternative mRNA splicing and related mechanisms; (ii) the various isoforms have different regulatory mechanisms, mediated by their unique amino-terminal regulatory domains; (iii) the isoforms differ widely in their pattern of tissue expression. These mechanisms explain why many PDE-opathies are gain-of-function mutations and how they exemplify uniqueness and redundancy within a multigene family.
Conic Cap-Suction Uemr for EN Bloc Resection of Non-Granular Pseudodepressed Colonic Lesion: A Novel Technique When Conventional Snaring is not Possible
Authors: H Uchima, J Colán-Hernández, I Marín, R López, C Fumagalli, A Hernández, N Caballero, I Iborra, L González, V Moreno
Journal: Endoscopy (2021)

Colorectal lesions with a depressed component are difficult to snare and have a high risk of submucosal invasion.
Early mortality of acute myocardial infarction in patients with and without prior coronary revascularization surgery. A Coronary Artery Surgery Study Registry Study.
Authors: K BDavis, E LAlderman, A SKosinski, EPassamani, J WKennedy
Journal: Circulation (1992)

BACKGROUNDThe Coronary Artery Surgery Study (CASS) Registry is used to evaluate the effect of various baseline clinical and angiographic factors on mortality after acute out-of-hospital myocardial infarction (MI) in patients with and without prior coronary bypass surgery.METHODS AND RESULTSAmong the CASS Registry patients, there were 985 medical and 369 surgical patients who had an MI out of the hospital within 3 years after enrollment. In the medical group, 20% died before hospitalization. Medical patients with baseline three-vessel disease or left ventricular (LV) dysfunction were at high risk of immediate death. For medical patients who were hospitalized with MI, mortality was higher for older patients and those with severe angina as well as for those with extensive disease and LV dysfunction. The total 30-day mortality for medical patients was 36%. In the surgical group, 12% died before hospitalization. Surgical patients with LV dysfunction or prior MI were at highest risk of immediate death. For surg...
Are aortic aneurysms caused by atherosclerosis
Authors: DReed, GStemmermann, THayashi
Journal: Circulation (1992)

BACKGROUNDThe emerging controversy concerning the causal role of atherosclerosis in the development of aortic aneurysms was examined using the accumulated clinical and autopsy data obtained during a 20-year follow-up of a cohort of more than 8,000 men of Japanese ancestry in Hawaii.METHODS AND RESULTSAnalyses of 174 clinical incident events indicated that there were two types of aneurysmal disease, 151 aortic aneurysms and 23 aortic dissections. The baseline risk factors that predicted the clinical aortic aneurysms were the same factors that predicted aortic atherosclerosis in the same cohort, namely, high blood pressure, high serum cholesterol, and cigarette smoking. These same risk factors were also significantly associated with the occurrence of 27 aortic aneurysms among 293 autopsied men. The less common aortic dissections had an age-specific incidence pattern indicative of an innate susceptibility precipitated by an exposure to another factor. This pattern was consistent with the findings that the in...
Assessment of papillary muscle function in the intact heart.
Authors: MMarzilli, H NSabbah, SGoldstein, P DStein
Journal: Circulation (1985)

A technique is described to localize the anterolateral papillary muscle and to assess its performance in vivo. Using this technique, we measured sequentially the pressure generated within the anterolateral papillary muscle and its changes in length during the cardiac cycle in eight open-chest anesthetized dogs. Pressure within the anterolateral papillary muscle was measured with a 1.6 mm diameter micromanometer probe. Its dimensional changes were measured with ultrasonic crystals. Pressure within the anterolateral papillary muscle exceeded left ventricular pressure throughout the entire cardiac cycle. A difference of 200 +/- 23 mm Hg was present between systolic pressure in the anterolateral papillary muscle and left ventricular systolic pressure (348 +/- 25 vs 149 +/- 6 mm Hg) (p less than .001). Shortening of the anterolateral papillary muscle began 25 +/- 2 msec after the upstroke of the aortic pressure, continued throughout isovolumic relaxation, and was maximal 68 +/- 5 msec after the apex of the aor...
Efficacy of Bile Aspiration Plus Brushing to Diagnose Malignant Biliary Strictures During Endoscopic Retrograde Cholangiopancreatography: A Single Tertiary Center Experience
Authors: K Amalou, F Belghanem, A Bousseloub, A TIBOUK
Journal: Endoscopy (2021)

Aims Our study aimed to evaluate the diagnostic performance of bile aspiration associated with biliary brushing during ERCP to diagnose a malignant stricture, compared to brushing alone.
The role of an accessory atrioventricular pathway in reciprocal tachycardia. Observations in patients with and without the Wolff-Parkinson-White syndrome.
Authors: H JWellens, DDurrer
Journal: Circulation (1975)

To study the pathway of tachycardia in patients with the Wolff-Parkinson-White (WPW) syndrome and reciprocal tachycardias, results from intracavitary recordings and atrial and ventricular stimulation were reviewed in 71 patients with the WPW syndrome and 54 patients without pre-excitation. In all patients a reproducible tachycardia could be initated and terminated by appropriately timed electrical stimuli. The following findings were accepted as suggesting the participation of an accessory pathway in the tachycardia circuit: 1) no increase in ventriculo-atrial conduction (V-A C) time following ventricular stimuli given with increasing prematurity; 2) activation of right or left atrium (depending upon the location of the atrial end of the accessory pathway) prior to activation of atrium in the His bundle lead; 3) slowing of tachycardia following bundle branch block to the ventricle in which the accessory pathway inserts; 4) V-A C time of early stimuli on the ventricle during the tachycardia equal to or les...
Single-chamber cardiac pacing with activity-initiated chronotropic response: evaluation by cardiopulmonary exercise testing.
Authors: D GBenditt, MMianulli, JFetter, D WBenson, ADunnigan, EMolina, C CGornick, AAlmquist
Journal: Circulation (1987)

In this study, sequential cardiopulmonary exercise testing was used to assess the physiologic benefits of a single-chamber ventricular pacing system that utilizes a piezoceramic sensor to adjust heart rate by detecting physical activity. An initial exercise test was conducted with the pacemaker programmed (based on a randomization table) to either the fixed rate (VVI, 70 beats/min) or rate-variable (VVI-Act) mode, and the results were compared with those obtained during a second exercise test in which the pacemaker was programmed to the alternate pacing mode. A 1.5 to 2 hr rest period was permitted between exercise tests, each of which consisted of a symptom-limited constant speed (3.0 mph) Balke protocol with 2 min stages commencing at 0.0% grade with increments of 2.5% at end of each stage. Compared with findings during fixed-rate VVI pacing, VVI-Act pacing was associated with greater exercise-induced positive chronotropic response (mean maximum heart rate VVI-Act 128 +/- 15.3 beats/min vs VVI 90 +/- ...
Left ventricular end-diastolic pressure volume relationships with experimental acute global ischemia.
Authors: IPalacios, R AJohnson, J BNewell, W JPowell
Journal: Circulation (1976)

The mechanism of elevation of left ventricular end-diastolic pressure during acute global ischemia was evaluated by examiniation of the relative contributions of a decrease in contractility and an alteration of the pressure-volume relationship. The external circumference (mercury-in-silastic gauge) pressure relationship, as an index of the pressure-volume relationship, was studied in beta adrenergic and ganglionic blocked, open chest dogs on right heart bypass at constant heart rate ane aortic pressure. Ischemia of one and two hours' duration was produced by reducing total coronary blood flow in cannulated left and right coronary arteries until left ventricular end-diastolic pressure rose significantly. At a constant stroke work, left ventricular end-diastolic pressure rose from 5.0 +/- 0.5 to 15.0 +/- 0.5 cm H2O in the experiments of one hour of ischemia, and from 7.0 +/- 1.0 to 17.0 +/- 1.0 cm H2O in experiments of two hours of ischemia. Ischemia was followed by one hour of restoration of coronary blood...
CD45RO<sup>-</sup>CD8<sup>+</sup> T cell-derived exosomes restrict estrogen-driven endometrial cancer development via the ERβ/miR-765/PLP2/Notch axis
Authors: Wen-Jie Zhou, Jie Zhang, Feng Xie, Jiang-Nan Wu, Jiang-Feng Ye, Jian Wang, Ke Wu, Ming-Qing Li
Journal: Theranostics (2021)

Rationale: Estrogen-dependent cancers (e.g., breast, endometrial, and ovarian cancers) are among the leading causes of morbidity and mortality in women worldwide. Recently, exosomes released by tumor-infiltrating CD8+ T cells have been under the spotlight in the field of cancer immunotherapy. Our study aims at elucidating the underlying mechanisms of the crosstalk between estrogen signaling and CD8+ T cells, and possible intervention values in uterine corpus endometrial cancer (UCEC). Methods: Micro RNA-seq was conducted to screen differentially expressed micro RNA in UCEC. Bioinformatic analysis was processed to predict the target of miR-765. RNA silencing or overexpressing and pharmacologic inhibitors were used to assess the functions of ERβ/miR-765/PLP2/Notch axis in UCEC cell proliferation and invasion in vivo and in vitro. In vivo imaging was performed to evaluate the metastasis of tumor in mice. Combined fluorescent in situ hybridization for miR-765 and immunofluorescent labeling for CD8 was carried out to prove the co-localization between miR-765 and CD8+ T cells. Exosomes derived from CD45RO-CD8+ T cells were isolated to detect the regulatory effects on UCEC. Results: miR-765 is characterized as the most downregulated miRNA in UCEC, and there is a negative correlation between miR-765 and Proteolipid protein 2 (PLP2) in UCEC lesion. Estrogen significantly down-regulates miR-765 level, and facilitates the development of UCEC by estrogen receptor (ER) β. Mechanistically, this process is mediated through the miRNAs (e.g., miR-3584-5p, miR-7-5p, miR-150-5p, and miR-124-3p) cluster-controlled regulation of the PLP2, which further regulates Ki-67 and multiple epithelial-mesenchymal transition (EMT)-related molecules (e.g, E-cadherin and Vimentin) in a Notch signaling pathway-dependent manner. Interestingly, the selective ER degrader Fulvestrant alleviates estrogen-mediated miR-765/PLP2 expression regulation and UCEC development in ERβ-dependent and -independent manners. Additionally, CD45RO-CD8+ T cell-derived exosomes release more miR-765 than that from CD45RO+CD8+ T cells. In therapeutic studies, these exosomes limit estrogen-driven disease development via regulation of the miR-765/PLP2 axis. Conclusions: This observation reveals novel molecular mechanisms underlying estrogen signaling and CD8+ T cell-released exosomes in UCEC development, and provides a potential therapeutic strategy for UCEC patients with aberrant ERβ/miR-765/PLP2/Notch signaling axis.
Effects of norepinephine, calcium, and rate of discharge on 42K movements in canine cardiac Purkinje fibers.
Authors: EMusso, MVassalle
Journal: Circulation Research (1978)

We studied the effect of norepinephrine, calcium concentration, and rate of discharge in the presence of different [Ca2+]0 on radioactive potassium movements in cardiac Purkinje fibers. The following results were obtained: (1) norepinephrine increases potassium uptake in quiescent fibers and in fibers driven at constant rate, but more in the latter; (2) norepinephrine also increases potassium uptake in quiescent fibers depolarized at the plateau; (3) increasing [Ca2+]0 increases potassium uptake in fibers driven at constant rate; (4) increasing [Ca2+]0 may decrease K+ uptake in quiescent fibers; (5) increasing [Ca2+]0 decreases the rate of loss of tissue radioactivity in quiescent fibers and increases it in a driven fiber; (6) increasing the driving rate increases potassium uptake in low and high [Ca2+]0; (7) high [Ca2+]0 increases K+ uptake, especially at low rates; (8) norepinephrine is less effective in increasing K+ uptake in the presence of a high [Ca2+]0. We conclude that: (a) norepinephrine increas...
Abstract 15751: Pharmacodynamic Effect of ARO-ANG3, an Investigational RNA Interference Targeting Hepatic Angiopoietin-like Protein 3, in Patients With Hypercholesterolemia
Authors: Gerald F Watts, Christian Schwabe, Russell Scott, Patrick Gladding, David Sullivan, John Baker, Peter Clifton, James Hamilton, Bruce Given, Javier San Martin, Stacey Melquist, Ting Chang, Natasa Rajicic, Ira J Goldberg, Daniel Gaudet, Joshua W Knowles, Robert A Hegele, Christie M Ballantyne
Journal: Circulation (2020)

Background: Angiopoietin-like protein 3 (ANGPTL3) regulates triglyceride (TG) and lipoprotein (LP) metabolism by inhibiting liver and endothelial LP lipases and reduces plasma LDL-C. In Phase 1 Study AROANG1001 (NCT03747224), single and multiple doses of RNA interference therapeutic ARO-ANG3 (100, 200, or 300 mg; n=36) in healthy volunteers substantially reduced ANGPTL3, LDL-C, and other LPs (AHA 2019) compared with placebo (n=16). Purpose: We report preliminary results following repeat doses (days 1 and 29) of ARO-ANG3 in patients with heterozygous familial hypercholesterolemia (FH) with elevated LDL-C despite statin therapy and average LDL-C of 130 mg/dL. An additional group (non-FH patients) had LDL-C &gt; 70 mg/dL despite statin therapy. Methods: Seventeen FH patients received open-label, subcutaneous, ARO-ANG3 100 mg (n=6), 200 mg (n=6), or 300 mg (n=5). Nine non-FH, high risk patients with elevated LDL-C not at goal received either 200 mg ARO-ANG3 (n=6) or placebo (n=3) using a randomized double-blind design. Pharmacodynamic markers included serum ANGPTL3, LDL-C, TG, and others. Results: Results are reported as of 04 May 2020. In FH patients, ARO-ANG3 significantly reduced mean ANGPTL3 levels between 62-92% at week 16 in a dose-dependent manner (Table). LDL-C (23-37%) and TG (25-43%) were consistently reduced at all doses (Table). The mean percent reductions in non-FH patients for ANGPTL3 (85%), LDL-C (28%), and TG (29%) were comparable to those in FH patients, despite their initially lower LDL-C at baseline. As of 15 May 2020, there were no drug-related serious or severe adverse events (AEs) or discontinuations and most AEs were mild. The most common AEs reported in subjects receiving ARO-ANG3 were respiratory tract infection (30% of subjects) and injection site AEs (13% of subjects). Conclusions: In FH and non-FH patients, repeat doses of ARO-ANG3 significantly reduced ANGPTL3, LDL-C, and TG, with favorable safety.