POS0810 PULMONARY FINDINGS ON HIGH-RESOLUTION COMPUTED TOMOGRAPHY IN TAKAYASU ARTERITIS
Authors: X. Kong, J. Zhang, J. Lin, P. LV, H. Chen, Z. Ji, X. Dai, X. Jin, L. Ma, L. Jiang
Journal: Annals of the Rheumatic Diseases (2021)

Background: Takayasu arteritis (TA) is a chronic granulomatous large-vessel vasculitis most commonly seen in women under 50 years of age[1]. The pulmonary arteries are less often involved, with the frequency of involvement varying widely between countries (from 4% to &gt;50%) [2–5]. Respiratory symptoms or signs and pulmonary imaging findings in TA have not been fully investigated [6–7]. Objectives: This study aimed to describe pulmonary high-resolution computed tomography (HRCT) findings in TA and to determine possible causes. Methods: A total of 243 TA patients were enrolled from a prospective cohort after excluding 260 patients with other pulmonary disorders or incomplete data. Clinical data including symptoms, lab results, imaging information were collected. Pulmonary HRCT were interpreted by two radiologist who were blinded to patients’ clinical information. Abnormal pulmonary features were recorded as nodules, stripe opacity (linear opacity), patchy opacity, ground-glass opacity, pleural thickening, pleural effusion, pulmonary infarction, mosaic attenuation, pulmonary bronchiectasis, pulmonary oedema. After evaluation, patients were divided into two groups: those with normal lung HRCT and those with abnormal lung HRCT. Clinical characteristics were compared between groups and binary logistic regression analysis was applied to identify potential risk factors for the lung lesions. Follow-up HRCT (obtained in 64 patients) was analysed to study changes in pulmonary lesions after at least 6 months’ treatment. Results: Of the 243 patients, 107 (44.0%) had normal lung HRCT while 136 (56.0%) had abnormal lung HRCT, including stripe opacity (60.3%), nodules (44.9%), patchy opacity (25.0%), pleural thickening (15.4%), pleural effusion (10.3%), ground-glass opacity (8.1%), pulmonary infarction (6.6%), mosaic attenuation (4.4%), bronchiectasis (3.7%), and pulmonary oedema (2.2%). Patients with abnormal HRCT were significantly more likely to have type II arterial involvement (25% vs. 12.2%, P = 0.04), pulmonary arterial involvement (PAI; 21.3% vs. 5.6%, P &lt; 0.001), pulmonary hypertension (20.6% vs. 8.4%, P = 0.01), and abnormal heart function (27.9% vs. 7.6%, P &lt; 0.001). Logistic regression analysis demonstrated that PAI (OR = 3.0, 95% CI= 1.1-8.4, P=0.03), worsened heart function (OR = 2.7, 95% CI = 1.1-6.6, P=0.03), and age (OR = 1.1, 95% CI = 1.0-1.1, P&lt;0.01) were associated with presence of pulmonary lesions. Pulmonary infarction, pleural effusion, and patchy opacities improved partially after treatment. Conclusion: Pulmonary lesions are not rare in patients with TA. Age, PAI, and worsened heart function are potential risk factors for presence of pulmonary lesions in TA. References: [1]Jennette JC, Falk RJ, Bacon PA, et al. 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum 2013;65:1-11. [2]Kong X, Ma L, Wu L, et al. Evaluation of clinical measurements and development of new diagnostic criteria for Takayasu arteritis in a Chinese population. Clin Exp Rheumatol. 2015; 33(2 Suppl 89): S-48-55. [3]Nooshin D, Neda P, Shahdokht S, Ali J. Ten-year Investigation of Clinical, Laboratory and Radiologic Manifestations and Complications in Patients with Takayasu’s Arteritis in Three University Hospitals. Malays J Med Sci. 2013; 20(3):44-50. [4]Bicakcigil M, Aksu K, Kamali S, et al. Takayasu’s arteritis in Turkey – clinical and angiographic features of 248 patients. Clin Exp Rheumatol. 2009; 27(1 Suppl 52):S59-64. [5]Kechaou M, Frigui M, Ben Hmida M, Bahloul Z. Takayasu arteritis in Southern Tunisia a study of 29 patients. Presse Med. 2009; 38(10):1410-4. [6]Dou JB, Gong JN, Ma ZH, Kuang TG, Yang YH. The analysis of the clinical records diagnosed as Takayasu’s arteritis with pulmonary vascular involvement. Zhonghua Jie He Hu Xi Za Zhi. 2016; 39(8):603-7. [7]Nd Perera G, C Jayasinghe A, D Dias L, Kulatunga A. Bronchiectasis and hoarseness of voice in takayasu arteritis: a rare presentation. BMC Res Notes. 2012; 5:447. Disclosure of Interests: None declared