tbuckley/cabot-search huggingface dataset:
Dry eye syndrome in patients with allergic eye disease
Authors: Natalhie Acuna Ortega, Sandra González Díaz, Jesus Mohamed Hamsho, Karim Mohamed Noriega, Alejandra Macías Weinmann, Rosa Guzmán Avilán, Wendy Santos Fernández, Jose Murillo Rodríguez, Rodrigo Pacheco González
Journal: Journal of Allergy and Clinical Immunology (2022)
BERLIN
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Novel approach to endoscopic submucosal dissection using an additional working channel: a case report
Authors: Francesco Azzolini, Francesco Vito Mandarino, Alberto Barchi, Paolo Biamonte, Maria Napolitano, Dario Esposito, Silvio Danese
Journal: Endoscopy (2022)

A 72-year-old man underwent endoscopic submucosal dissection (ESD) of a 7-cm mixed-type laterally spreading tumor of the distal rectum, histologically defined as intramucosal adenocarcinoma. During subsequent surveillance, a 4-cm nonpolypoid lesion was detected on the resection scar ([Fig. 1]). We performed a novel technique for ESD, using an external additional working channel (AWC; Ovesco Endoscopy, Tübingen, Germany), called “ESD+,” to eradicate the recurrent lesion ([Fig. 1, ] [Fig. 2, ] [Fig. 3]).
The Propaganda for Reform
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
You Did Not Teach Me What You Thought You Did
Authors: Marie Archambault Carlson
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Covid-19: Government writes off £10bn on unusable, overpriced, or undelivered PPE
Authors: Gareth Iacobucci
Journal: BMJ (2022)

The government has written off almost £10bn of spending on personal protective equipment (PPE) that was either unusable, above market price, or was not delivered, official accounts show.The Department of Health and Social Care's annual report and accounts 1 for 2020-21, show that £8.7bn worth of PPE purchased early in the pandemic was written off.This included £673m for defective PPE not suitable for any use, £2.6bn for items not suitable for NHS use that may be suitable for other uses, £4.
Coagulation-independent effects of thrombin and Factor Xa: role of protease-activated receptors in pulmonary hypertension
Authors: Christine Joseph, Eva Maria Berghausen, Arnica Behringer, Bernhard Rauch, Henrik ten Freyhaus, Leoni Luisa Gnatzy-Feik, Max Krause, Dickson W L Wong, Peter Boor, Stephan Baldus, Marius Vantler, Stephan Rosenkranz
Journal: Cardiovascular Research (2022)

Abstract Aims Pulmonary arterial hypertension (PAH) is a devastating disease with limited therapeutic options. Vascular remodelling of pulmonary arteries, characterized by increased proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs), is a hallmark of PAH. Here, we aimed to systematically characterize coagulation-independent effects of key coagulation proteases thrombin and Factor Xa (FXa) and their designated receptors, protease-activated receptor (PAR)-1 and -2, on PASMCs in vitro and experimental PAH in vivo. Methods and results In human and murine PASMCs, both thrombin and FXa were identified as potent mitogens, and chemoattractants. FXa mediated its responses via PAR-1 and PAR-2, whereas thrombin signalled through PAR-1. Extracellular-signal regulated kinases 1/2, protein kinase B (AKT), and sphingosine kinase 1 were identified as downstream mediators of PAR-1 and PAR-2. Inhibition of FXa or thrombin blunted cellular responses in vitro, but unexpectedly failed to protect against hypoxia-induced PAH in vivo. However, pharmacological inhibition as well as genetic deficiency of both PAR-1 and PAR-2 significantly reduced vascular muscularization of small pulmonary arteries, diminished right ventricular systolic pressure, and right ventricular hypertrophy upon chronic hypoxia compared to wild-type controls. Conclusion Our findings indicate a coagulation-independent pathogenic potential of thrombin and FXa for pulmonary vascular remodelling via acting through PAR-1 and PAR-2, respectively. While inhibition of single coagulation proteases was ineffective in preventing experimental PAH, our results propose a crucial role for PAR-1 and PAR-2 in its pathobiology, thus identifying PARs but not their dedicated activators FXa and thrombin as suitable targets for the treatment of PAH.
Ureteral Tumors
Authors: Harry Bergman
Journal: JAMA (1964)

<h3>To the Editor:—</h3> Robards and his associates in the March 7, 1964, issue ofThe Journal(<b>187</b>:778) in writing on "Primary Tumors of the Ureter" made several statements with which I take issue: I question calling papilloma a benign tumor. Recently, I did radical bladder surgery for a low ureteral metastasis from a previously "benign" mid-ureteral papilloma. In this case a nephrectomy and ureterectomy to the outer bladder wall had been performed. Careful analysis of the initial lesion had failed to reveal any submucosal infiltration, yet, metastasis did occur five years later. The goblet sign is mentioned in the urographic diagnosis of ureteral carcinoma, but no mention is made of the "coiled-catheter" sign. This was originally described by Drs. Friedenberg, Sayegh, and myself in the American Journal of Roentgenology, Radium Therapy and Nuclear Medicine (86:707 [Oct] 1961) and later corroborated by others as being of value. The statement that
ECMO during the COVID-19 pandemic: moving from rescue therapy to more reasonable indications
Authors: Christian Karagiannidis, Thomas Bein, Tobias Welte
Journal: European Respiratory Journal (2022)

Coronavirus disease 2019 (COVID-19) led to an unprecedented number of patients on mechanical ventilation, many of them presenting with severe acute respiratory distress syndrome (ARDS) [1–4]. Depending on the resources of national healthcare systems, extracorporeal membrane oxygenation (ECMO) was frequently applied during the pandemic [3, 5–7]. While intensive care unit experience improved with this new disease, various forms of drug therapies were introduced in living guidelines, resulting in a dynamic development in outcome of COVID-19 [8, 9]. Particularly noteworthy was the introduction of dexamethasone in the summer of 2020, and in 2021 the additional administration of tocilizumab in the early severe phase of the disease [10]. A third important factor that had a significant impact on the outcome of severe respiratory failure was the start of vaccination programmes, primarily for risk groups, depending on national strategies, followed by the general public. Shedding new light on ECMO treatment in ARDS: moving from rescue therapy to a standardised treatment option with defined indications <https://bit.ly/3zXAhyF>
Mutations in <i>DSTYK</i> and Dominant Urinary Tract Malformations
Authors: S. Sanna-Cherchi, R.V. Sampogna, N. Papeta, K.E. Burgess, S.N. Nees, B.J. Perry, M. Choi, M. Bodria, Y. Liu, P.L. Weng, V.J. Lozanovski, M. Verbitsky, F. Lugani, R. Sterken, N. Paragas, G. Caridi, A. Carrea, M. Dagnino, A. Materna-Kiryluk, G. Santamaria, C. Murtas, N. Ristoska-Bojkovska, C. Izzi, N. Kacak, B. Bianco, S. Giberti, M. Gigante, G. Piaggio, L. Gesualdo, D. Kosuljandic Vukic, K. Vukojevic, M. Saraga-Babic, M. Saraga, Z. Gucev, L. Allegri, A. Latos-Bielenska, D. Casu, M. State, F. Scolari, R. Ravazzolo, K. Kiryluk, Q. Al-Awqati, V.D. D'Agati, I.A. Drummond, V. Tasic, R.P. Lifton, G.M. Ghiggeri, A.G. Gharavi
Journal: New England Journal of Medicine (2013)

Congenital abnormalities of the kidney and the urinary tract are the most common cause of pediatric kidney failure. These disorders are highly heterogeneous, and the etiologic factors are poorly understood.We performed genomewide linkage analysis and whole-exome sequencing in a family with an autosomal dominant form of congenital abnormalities of the kidney or urinary tract (seven affected family members). We also performed a sequence analysis in 311 unrelated patients, as well as histologic and functional studies.Linkage analysis identified five regions of the genome that were shared among all affected family members. Exome sequencing identified a single, rare, deleterious variant within these linkage intervals, a heterozygous splice-site mutation in the dual serine-threonine and tyrosine protein kinase gene (DSTYK). This variant, which resulted in aberrant splicing of messenger RNA, was present in all affected family members. Additional, independent DSTYK mutations, including nonsense and splice-site mutations, were detected in 7 of 311 unrelated patients. DSTYK is highly expressed in the maturing epithelia of all major organs, localizing to cell membranes. Knockdown in zebrafish resulted in developmental defects in multiple organs, which suggested loss of fibroblast growth factor (FGF) signaling. Consistent with this finding is the observation that DSTYK colocalizes with FGF receptors in the ureteric bud and metanephric mesenchyme. DSTYK knockdown in human embryonic kidney cells inhibited FGF-stimulated phosphorylation of extracellular-signal-regulated kinase (ERK), the principal signal downstream of receptor tyrosine kinases.We detected independent DSTYK mutations in 2.3% of patients with congenital abnormalities of the kidney or urinary tract, a finding that suggests that DSTYK is a major determinant of human urinary tract development, downstream of FGF signaling. (Funded by the National Institutes of Health and others.).
From the Centers for Disease Control. Publication of guide for developing policies for HIV-infected students and school staff
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Response by Heng et al to Letter Regarding Article, “Immediate and Midterm Cardiac Remodeling After Surgical Pulmonary Valve Replacement in Adults With Repaired Tetralogy of Fallot: A Prospective Cardiovascular Magnetic Resonance and Clinical Study”
Authors: Ee Ling Heng, Gerhard-Paul Diller, Michael A. Gatzoulis, Sonya V. Babu-Narayan
Journal: Circulation (2018)
Bone Loss in Women with Anorexia Nervosa
Journal: Annals of Internal Medicine (2000)

Summaries for Patients21 November 2000Bone Loss in Women with Anorexia NervosaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-10-200011210-00006 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Anorexia nervosa is an eating disorder that is common among young women. Persons with anorexia nervosa are obsessed with being thin and severely limit the amount that they eat. As a result, they become undernourished. Health consequences of this serious and potentially deadly disease include osteopenia and osteoporosis. Osteopenia means that bones become less dense. When this bone thinning becomes severe, it is called osteoporosis. Persons with osteoporosis are at high risk for broken bones. Bone loss can begin after only 6 months of anorexia nervosa. Little is ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Prevalence and Predictive Factors for Regional Osteopenia in Women with Anorexia Nervosa.” It is in the 21 November 2000 issue of Annals of Internal Medicine (volume 133, pages 790-794). The authors are S Grinspoon, E Thomas, S Pitts, E Gross, D Mickley, K Miller, D Herzog, and A Klibanski.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPrevalence and Predictive Factors for Regional Osteopenia in Women with Anorexia Nervosa Steven Grinspoon , Elizabeth Thomas , Sarah Pitts , Erin Gross , Diane Mickley , Karen Miller , David Herzog , and Anne Klibanski Metrics 21 November 2000Volume 133, Issue 10Page: I-53KeywordsAnorexia nervosaBoneBone densityBone resorptionEating disordersHipOsteopeniaOsteoporosisSkeletonSpine ePublished: 21 November 2000 Issue Published: 21 November 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
ACC/AHA/NHLBI clinical advisory on the use and safety of statins11When citing this document, the American College of Cardiology, American Heart Association, and National Heart, Lung and Blood Institute would appreciate the following citation format: Pasternak RC, Smith SC, Jr., Bairey-Merz CN, Grundy SM, Cleeman JI, Lenfant C. ACC/AHA/NHLBI Advisory on the Use and Safety of Statins. J Am Coll Cardiol 2002;40:568–73.22This document is available on the Web sites of the ACC (www.acc.org), the AHA…
Authors: Richard C Pasternak, Sidney C Smith, C.Noel Bairey-Merz, Scott M Grundy, James I Cleeman, Claude Lenfant
Journal: Journal of the American College of Cardiology (2002)
Erratum: Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity
Authors: Sidney Altman, M Karpuj, M Becher, J Springer, D Chabas, R Pedotti, S Youssef, D Mitchell, L Steinman, S Strowski, S Benoit, G Conarello, X.-M Salituro, K Guan, S Liu, B Woods, K Moley, -Y Chi, C Knudson, S Korsmeyer, M Mueckler
Journal: Nature Medicine (2002)
Myocardial Infarction without Arterial Obstruction in Patient Post COVID-19 Treatment
Authors: Huang W. L.
Journal: Clinical Cardiology and Cardiovascular Interventions (2022)

Introduction: Some risks factors associated with COVID-19 infections were established such as coronary artery disease in patients with SARS-CoV-2 infections. The use of highly concentrated medications according to Arndt Schultz Law can induce reduction in the vital energy, leading to stagnation of Blood and propensity to have myocardial infarction even without arterial obstruction. Purpose: to demonstrate that patient with COVID-19 infection that received highly concentrated medications to treat this infection, have more propensity to develop myocardial infarction some days after the treatment instituted. Methods: through one case report of 42 years-old-male patient with history of acquired COVID-19 on January 2nd 2021. He was admitted in the hospital due to dyspnea symptoms, myalgia, and needs oxygenation. He received the medications, Ivermectin, Hydroxychloroquine, corticosteroids. After 18 days of the initial manifestations, the patient felt pain in the chest and went to the hospital and they found that his troponin was increasing gradually and after two hours of it increased many times and the physician decided to admit him again in the hospital to make more exams. The patient was submitted to catheterization and the result of this procedure were that all his coronary were in perfect state of health without any obstruction and they treated him as he had myocardial infarction. After three months, the patient went to my clinic due to post herpetic neuralgia and also to evaluate his condition and I performed the chakras’ energy centers measurement. Results: the results of this chakras’ energy centers measurement revealed that all his chakras were in the lowest level of energy (rated in one) with exception of the seventh (that was normal, rated in eight). I began his treatment using homeopathies medications according to the theory Constitutional Homeopathy of the Five Elements based on Traditional Chinese Medicine. Conclusion; the conclusion of this study is that patients treated with highly concentrated medications to treat SARS-CoV-2 infection can develop myocardial infarction even without arterial obstruction due to energy deficiency state prior to this infection and aggravated many times with to the use of any type of highly concentrated medications to treat this kind of infection, because it will reduce the vital energy that was already very low before the infection and will cause stagnation of Blood in any part of the body, in this case, inside the coronary artery.
International Comments
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal