tbuckley/cabot-search huggingface dataset:
Abstract 13820: Trends in Preterm Delivery Among Multiple Gestation Births With Critical Congenital Heart Disease
Authors: Michelle Pelka, Keila N Lopez, Jason Salemi, Alireza Shamshirsaz, Daniel Castellanos, Shaine A Morris
Journal: Circulation (2021)

Introduction: Studies have demonstrated that preterm delivery (PTD) in infants with critical congenital heart disease (CCHD) is associated with worse outcomes compared to those delivered at term. PTD in singletons with CCHD is decreasing. However, little is known about PTD trends over time in multiple gestation deliveries (MGD) with CCHD. Hypothesis: We hypothesized that in a state population-based cohort over the last 20 years, PTD in MGD with CCHD initially increased compared to the general population, but more recently decreased coincident with advancements in prenatal detection of CCHD. Methods: The Texas Public Use Data File 1999-2018 was used to evaluate percent PTD (&lt;37 weeks) in MGD with CCHD (diagnoses requiring intervention &lt;1 year of age). Trends in PTD were compared with all Texas livebirths of MGD. We then compared trends by race/ethnicity and insurance. Results: Of 7,428,329 livebirths from 1999-2018, 211,931 (2.8%) were MGD and of those 129,253 (61%) were PTD. Overall, the rate of PTD increased from 1999 to 2003 (mean increase of 1%/y) then remained constant 2003-2018 (Figure). Of 308 MGD with CCHD, 229 (74%) were PTD. The rate of PTD in CCHD decreased from 1999 to 2003 (mean decrease of 2.2%/y) then remained relatively constant 2003-2018. When examining by race/ethnicity, there was an overall decrease in PTD with CCHD in Non-Hispanic White and Hispanic MGD, but an increase in Non-Hispanic Black MGD (Figure). There was a decrease in PTD with CCHD for those with private insurance however an increase for those with public insurance (Figure). Conclusions: For MGD with CCHD, while PTD rates initially decreased, they have remained somewhat constant over the last 15 years. The rate of PTD in non-Hispanic Black MGD and in those publicly insured, however, remains the highest. Mechanisms for persisting disparities in PTD for these populations requires further investigation, including determining associations with other social determinants of health and implicit bias.
TAMI-07. TUMOR-EDUCATED PLATELETS GUIDE BREAST CANCER BRAIN METASTASIS AND PROMOTE THERAPEUTIC RESISTANCE
Authors: Elie Tabet, Bakhos Tannous
Journal: Neuro-Oncology (2021)

Abstract BACKGROUND Platelets have been shown to play an important role in systemic and local tumor modulation. Once encountered by tumor cells, platelets are educated to collect and release pro-tumor factors in the tumor/microenvironment, serving as a guiding partner for metastasis. This educational program, however, is not well understood. METHODS Wild-type platelets (WTPs) were isolated from blood of healthy humans or mice, whereas tumor-educated platelets (TEPs) were isolated from blood of breast cancer patients or from tumor-bearing donor mice. The tumorigenic and modulatory effect of these two types of platelets on breast cancer was examined in-vitro and in-vivo. RESULTS Here, we show that TEPs acquire tumor promoting functions and drive breast cancer progression, metastasis to distal sites specifically the brain, as well as therapeutic resistance. Importantly, TEPs promoted an increased pro-tumorigenic effect on metastatic breast cancer, compared to their wild-type counterpart, promoting epithelial to mesenchymal transition through NF-κB/STAT3 signaling axis via C/EBPβ transcription factor. CONCLUSION Our findings point to the important role of TEPs in breast cancer brain metastasis and therapeutic resistance, which could have a major implication in other tumor types, endorsing TEPs as a potential therapeutic target.
Abstract 11877: Arrhythmogenic Right Ventricular Cardiomyopathy Patients with a Markedly Enlarged RV Compressing LV to Left Side Have an Atypical Distribution of Epsilon Waves and Elevated Plasma BNP
Authors: Nobusada Funabashi, Kohki Nakamura, takehio sasaki, Shigeto Naito, Yoshio Kobayashi
Journal: Circulation (2021)

Introduction: Epsilon waves on V1-3 leads are specific ECG findings in patients with arrhythmogenic right ventricular (RV) cardiomyopathy (ARVC). 4D cardiac CT visualizes ARVC characteristics, such as fibro-fatty invasion into RV and left ventricular (LV) myocardium (RVM, LVM), an enlarged RV, reduced RV motion, and bulging. Hypothesis: We hypothesize that epsilon waves in V4-6 leads suggest LV invasion in ARVC. Alternatively, extreme RV enlargement may compress the LV and cause clockwise rotation; an enlarged RV may itself cause epsilon waves in V4-6 leads. Methods: Retrospective analysis of 17 patients (11 males, 57±17 yrs) with suspected ARVC undergoing cardiac CT and ECG, 9 of whom met 2010 ARVC task force criteria. Result: All 9 patients had epsilon waves ; 5 had fibro-fatty invasion into the LVM. We divided the 9 into 5 groups by CT: 1) markedly enlarged RV compressing the LV to the left side with fibro-fatty changes exclusively in RVM (N=1); 2) similar findings in both RVM and LVM (N=2); 3) moderately enlarged RV without compression of the LV to the left side and fibro-fatty changes exclusively in RVM (N=3); 4) the same in both RVM and LVM (N=2); 5) severe mitral valve regurgitation, a markedly enlarged LV, and a fibro-fatty change in both RVM and LVM (N=1). The patient in group (gp) 1 showed epsilon waves in V1-6 leads, patients in gp 2 had epsilon waves in V1-6 (N=1), and V3-5 (N=1) leads; patients in gp 3 had epsilon waves in V1-4 (N=2), and V1-3 (N=1) leads, patients in gp 4 had epsilon waves in V1-3 (N=1), and V1, 2 (N=1) leads; finally, the patient in gp 5 had epsilon waves in V4-6 leads. Plasma BNP levels were significantly greater in patients in gp 1 &amp; 2 than gp 3 &amp; 4 (1255±838 vs 80±52 pg/ml, P=0.016). Conclusions: ARVC patients with a markedly enlarged RV compressing the LV to the left side (gp 1,2) had a broad (V1-6) or different range (V3-5) distribution of epsilon waves and significantly elevated plasma BNP independent of fibro-fatty invasion of the LV, different from typical ARVC (gp 3,4).
Abstract 8868: Impact of Obesity on Sinus Nodal Dysfunction - A Retrospective National Database Study
Authors: Michael Aljadah, Hafeez Shaka, Asim Kichloo, Zain Elamir, Luke DeHart, Michael Albosta, Genaro Velazquez, IRIAGBONSE ASEMOTA, Emmanuel Akuna, Khalid Mohiuddin, khalil kanjwal
Journal: Circulation (2021)

Introduction: Sick sinus syndrome (SSS) or sinus node dysfunction (SND) is degenerative disease of the sinus node. Previous research lacks objective data on the relationship between obesity and SND, with respect to inpatient mortality. This study aimed to discern a difference in mortality by using the National Inpatient Sample (NIS) database to identify patients with the principal discharge diagnosis of SSS with and without a secondary diagnosis of obesity. Methods: Hospitalizations of patients 18 years and older, who had a principal diagnosis of SSS with and without a secondary diagnosis of obesity in the US between January 1, 2016 and December 31, 2017 were obtained from the Nationwide Inpatient Sample (NIS) database for a cohort study. Patient and hospital characteristics are outlined in Table 1. Obese patients were classified according to a BMI&gt;30. Inpatient mortality between non-obese and obese groups was assessed as the primary outcome. Secondary outcomes included total hospital charges (THC), hospital length of stay (LOS), rate of pacemaker insertion, rate of acute renal failure (AKI), and rate of cardiogenic shock. Results: Patients with SSS and obesity, in comparison to those without obesity, had similar odds of inpatient mortality (aOR: 1.09, 95% CI 0.66-1.80), p=0.727) when adjusted for co-morbidities. Patients with obesity had higher length of stays (LOS) (4.5 vs 4 days, 0.2 CI: 0.1 - 0.4, p=0.002), higher odds of pacemaker insertion (aOR: 1.14, 95% CI:1.02-1.26, p=0.018), and higher rates of cardioversion/defibrillation (aOR: 1.36, 95% CI: 1.08 - 1.71, p=0.008). Summary of outcomes is outlined in Table 2. Conclusions: In conclusion, there was no difference between obese and non-obese patients with SND in regard to inpatient mortality, but obese patients may have higher lengths of stay and increased odds of pacemaker insertion and cardioversion or defibrillation during their hospital stay.
Abstract 12026: Correlates of Sleep Disordered Breathing and Cheyne-Stokes Respiration in Patients With Atrial Fibrillation Undergoing Pulmonary Vein Isolation
Authors: Akihiro Sato, Takatoshi Kasai, Hiroki Matsumoto, Shoko Suda, Sayaki Ishiwata, Takao Kato, Azusa Kurita, Ryo Naito, Hidemori Hayashi, Tohru Minamino
Journal: Circulation (2021)

Background: Sleep disordered breathing (SDB) is known as a common comorbidity in patients with atrial fibrillation (AF). Indeed, patients undergoing pulmonary vein isolation (PVI) for AF had a high prevalence of SDB in particular, Cheyne-Stokes respiration (CSR). The aim of the present study is to assess the correlates of SDB severity and CSR in AF patients undergoing PVI. Methods and Results: The study was conducted under a single-center, observational design. We enrolled 140 consecutive patients undergoing PVI. All participants underwent home sleep apnea test (ApneaLink Air, ResMed, Australia) which could determine the severity of SDB as assessed by apnea-hypopnea index (AHI) and the percent of CSR (%CSR) pattern. Overall, 33 (27.9%) patients was no SDB (AHI&lt;5), 53 (37.9%) patients was mild SDB (5≦AHI&lt;15), 33 (23.6%) patients was moderate SDB (15≦AHI&lt;30), and 15 (10.7%) patients was severe SDB(30≦AHI). Correlates of the increased AHI includes male sex (β=0.27, p=0.001), high age (β=0.19, p=0.0028), high body mass index (BMI) (β=0.29, p=0.0013), hypertension (β=0.18, p=0.038), and non-paroxysmal AF (β=0.17, p=0.047). On the other hand, correlates to %CSR rate includes male sex (β=0.17, p=0.026), high age (β=0.22, p=0.0054), non-paroxysmal AF (β=0.27, p=0.0005), high value of HbA1c (β=0.3, p&lt;0.0001), and greater N-terminal fragment of the Brain natriuretic peptide (NT-proBNP) (β=0.26, p=0.0007). Conclusion: Increased SDB severity correlated with male sex, high age, obesity, hypertension and chronicity of AF in patients with PVI. Correlates the percent of %CSR were male sex, high age, the chronicity of AF, high value of HbA1c, and greater NT-proBNP. Treatment for SDB should be consider for these AF patients, because SDB increases the recurrence ratio of AF after PVI.
NCOG-13. TUMOR-RELATED MOLECULAR DETERMINANTS OF NEUROCOGNITIVE DEFICITS IN PATIENTS WITH DIFFUSE GLIOMA
Authors: Emma van Kessel, Sharon Berendsen, Anniek Baumfalk, Hema Venugopal, Eva Krijnen, Wim Spliet, Wim van Hecke, Fabrizio Giuliani, Tatjana Seute, Martine van Zandvoort, Tom Snijders, Pierre Robe
Journal: Neuro-Oncology (2021)

Abstract BACKGROUND Cognitive impairment is a common and debilitating symptom in patients with diffuse glioma and is the result of multiple factors. We hypothesized that molecular tumor characteristics influence neurocognitive functioning (NCF), and we aimed to identify tumor-related markers of NCF in diffuse glioma patients. METHODS We examined the relation between cognitive performance (executive function, memory and psychomotor speed) and intratumoral expression level of molecular markers, in treatment-naive patients with diffuse glioma. We performed a single-center study in a prospectively collected cohort, through a two-step design: (1) differential expression and gene set enrichment analysis (GSEA) to identify candidate oncogenetic markers for cognitive impairment in a hypothesis-free manner. Nineteen molecular markers of interest were derived from this set of genes as well as from prior knowledge; (2) correlation of cognitive performance (executive function, memory and psychomotor speed) to intratumoral expression level of these nineteen molecular markers, measured with immunohistochemistry. RESULTS After correcting for tumor volume and location, we found significant associations, between expression level of CD3 and IDH on the one hand with psychomotor speed on the other; between IDH, ATRX, BDNF, CSNK2B, EAAT1, GAT-3, SRF and memory performance; and between IDH, P-STAT5b, CSNK2B and executive functioning. P-STAT5b, CD163, CD3 and SEMA3 were independently associated after further correction for histopathological grade. CONCLUSION Several molecular characteristics of gliomas are independent determinants of patients’ cognitive functioning. This suggests that besides tumor volume, location and histological grade, variations in glioma biology influence cognitive performance through mechanisms that include perturbation of neuronal communication. These results pave the way towards targeted cognition improving therapies in neuro-oncology.
Taking Down the Shingle
Authors: Diane Roston
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 110: Human-Induced Pluripotent Stem Cell Derived Exosomal Protein Induce Cardiac Regeneration
Authors: Ajit Magadum, Vandana Mallaredy, Grace Grace, Chunlin Wang, Rajika Roy, Darukeshwara Joladarashi, Charan Thej Gurrala, Zhongjian Cheng, Maria Cimini, May Truongcao, Anna Maria Lucchese, Carolina Gonzalez, Cindy Benedict, Raj Kishore
Journal: Circulation Research (2021)

Introduction: Cardiovascular diseases are the leading causes of death worldwide. After myocardial infarction (MI), there is a permanent loss of cardiomyocytes (CMs), and as the mammalian heart has limited regenerative capacity, it leads to Heart Failure. Recent studies from zebrafish and 1-day old mice showed that they could regenerate their heart through inducing existing CM proliferation. Attempts have been made to transiently reconstitute embryonic signaling in adult hearts, including overexpression of cell cycle activating genes with limited success. iPSC-derived extracellular vesicles (EV)/exosomes have been shown to improve cardiac function and some degree of CM renewal. However, the iPSC-EVs-mediated cardiac regeneration mechanism remains unclear and largely pertains to microRNAs and other RNAs, with a little elucidation of the role of iPSC-exosome proteins. Hypothesis: The myocardial delivery of iPSC-EV-specific protein improves cardiac function and remodeling post-MI by activating pro-proliferative and anti-oxidative stress molecular pathways. Methods and Results: Our preliminary studies showed that hiPSC-EVs induced the CM cell cycle in mice post-MI, and by employing a proteomic approach, we found a novel protein exclusively expressed in iPSC-EVs. The overexpression of hiPSC-EV enriched protein in the form of modRNA (modified mRNA) induced a robust CM cell cycle in rat neonatal CMs and in adult hearts post-MI. This increase in the CMs cell cycle by the modRNA was associated with reduced scar size, improved cardiac function (%EF 49.76 ± 5.8 vs. 27.47 ± 6.9 (control, Luc modRNA), respectively), and mice survival 28 days post-MI. Furthermore, using the siRNA and modRNA (inhibition and over-expression) approach, we found that the protein-induced Yap1-β-catenin molecular pathway stimulates CM proliferation. Furthermore, the overexpression protein post-MI inhibited the CM apoptosis (TUNEL + CMs, 1.3% ± 0.1 vs. 2.1% ± 0.11 (control)) by reducing oxidative stress and DNA damage response. Conclusion: The myocardial injection of iPSC-EV specific protein through a highly therapeutic modRNA tool improve cardiac function by inducing CMs proliferation, inhibiting oxidative stress, and reactivating cardiac regeneration post-injury.
EasyCatch, a convenient, sensitive and specific CRISPR detection system for cancer gene mutations
Authors: Yin Liu, Yanling Chen, Lu Dang, Yixin Liu, Shisheng Huang, Sanyun Wu, Peixiang Ma, Hongqiang Jiang, Yi Li, Yunbao Pan, Yongchang Wei, Xiaodong Ma, Ming Liu, Quanjiang Ji, Tian Chi, Xingxu Huang, Xinjie Wang, Fuling Zhou
Journal: Molecular Cancer (2021)
Abstract 13468: Single-Cell Driven Drug Repositioning Approach Identifies a New Anti-Atherosclerotic Compound Targeting Myeloid Cells
Authors: Letizia Amadori, Claudia Calcagno, Dawn M Fernandez, Simon Koplev, Nicolas F Fernandez, Ravneet Kaur, Roza Shamailova, Peik Sean Chong, Swathy Sajja, Sonum Naidu, Adam Ghotbi, Raphael Soler, Christopher Hill, Zahi A Fayad, Avi Ma'ayan, Chiara Giannarelli
Journal: Circulation (2021)

Introduction: Inflammation is a key driver of atherosclerosis. The identification of new treatments and strategies targeting the specific inflammatory signaling that persists in optimally treated atherosclerotic patients remain an unmet clinical need. Hypothesis: The integration of time-of-flight mass cytometry (CyTOF), gene expression analysis, and drug repositioning computational approaches applied to pre-clinical validation in models of the disease using non-invasive imaging will help to identify drugs tailored to residual inflammatory signaling in patients with atherosclerosis. Methods: We developed a new systems biology pipeline to identify new therapeutic/indication pair that combines CyTOF and RNA sequencing (RNA-seq) data analysis of clinical samples from patients with carotid and coronary artery disease (CVD) ( Fig. 1A ). This approach allowed the identification of new uses for existing compounds. The predicted anti-atherosclerotic effect was validated in ApoE-/- mice and in a rabbit model of atherosclerosis using 18 F-Fluorodeoxyglucose (FDG) PET-MRI. Results: We found a specific inflammatory signature in CD14 + monocytes stimulated with CVD plasma that was used to identify 50 small molecules predicted to reverse this signature. CyTOF screening of the top eight candidate compounds showed that Saracatinib—a phase 2a-ready Src/Abl inhibitor—blunted the inflammatory response found in CD14 + monocytes ( Fig. 1B ). The anti-atherosclerotic efficacy of Saracatinib was confirmed in ApoE-/- mice fed a high fat diet ( Fig.1C ). In the atherosclerotic rabbit model, Saracatinib reduced plaque inflammation measured as reduction of 18 F-FDG uptake by PET-MRI ( Fig. 1D ). Conclusions: These data support the use of our integrated systems biology pipeline as a powerful approach to identify new immune signature specific to patients with atherosclerosis that can be leveraged to identify new indications for existing drugs to treat cardiovascular disease.
Abstract 14180: RyR2 Hyperactivity Contributes to Arrhythmogenic Triggers in the ex vivo Human Right Ventricle
Authors: Jaclyn A Brennan, Rokhaya N Faye, Bjorn C Knollmann, Igor R Efimov
Journal: Circulation (2021)

Introduction: Sudden cardiac death (SCD) caused by VT/VF is a major cause of mortality and morbidity, accounting for up to 20% of all deaths in the United States. Novel antiarrhythmic targets and r...
Abstract 12565: Rotational Atherectomy in the Left Coronary System
Authors: Erika A Rodriguez Barriga, Augusto A Flores Galaviz
Journal: Circulation (2021)

It′s known that the Left Coronary Artery stenosis has greater mobility and mortality compared to the rest of the coronary tree, due to its size since the formation of plaques has a disseminated distribution, greater volume and severity of calcification. The use of rotational atherectomy (RA) has proven to be an effective tool to facilitate the sub-expansion of stents in atheromatous calcified lesions. We present a case study where plaque modification is performed by atherectomy and angioplasty in the Left Coronary system.A 62 years old female patient diagnosed with diabetes mellitus 2, systemic arterial hypertension and dyslipidemia. Antecedent of coronary angiography 10 days prior to admission due to chest pain and dyspnea, where found trivascular disease of left dominance with diffuse calcified lesion. She was programmed for RA with ROTABLATOR and ROTAWire system. It started by advancing the microcatheter on the angioplasty guide and exchanging for ROTAWIRE 0.009”. Subsequently, the 1.5 mm abrasive bur was advanced, rotating up to 6 times in the proximal and middle segment of the Anterior Descending Artery, proceeding to predilate with balloon noting a non-dilatable distal lesion, a 1.25 mm abrasive bur was passed, rotating up to 3 times, and it was decided to perform balloon predilatation and placement of spliced stents.Continuing with Circumflex Artery, an intermediate 0.014” Zinguer guide was advanced to the distal segment, spliced stents were placed in the proximal segment and it was dilated with a balloon to optimize results. It was decided to exchange guides and predilated the artery ostium, then it was decided to advance the stent using the Culotte bifurcation technique and a proximal optimization of the stent with a balloon was performed.Finally, a post-dilation was performed in the Anterior Descending Artery and the Left Coronary Trunk with a balloon to optimize a successful result (Figure 1), with no dissection image or thrombus. Final flow TIMI 3, TMP 3.