tbuckley/cabot-search huggingface dataset:
Evaluating the impact of a joint Clinical Nurse Specialist and Allied Health Care Professional clinic for neuro-oncology patients attending Velindre Cancer Centre, Cardiff
Authors: Rachel Evans, Rhian Burke, Cathryn Lewis, Helena Goode, Sarah Ellam, Amy Gee, Deborah Mullan, Rehana Begum, James Powell, Jillian MacLean, Najmus Iqbal, Owen Tilsley, Lisa Love-Gould, Kate Baker
Journal: Neuro-Oncology (2021)

Abstract Aims Key governing guidelines recognise that the holistic and complex needs of neuro-oncology patients are best served by a cohesive multidisciplinary team (MDT). Achieving a joint Clinical Nurse Specialist (CNS) and Allied Healthcare Professional (AHP) clinic (including Speech and Language Therapy, Physiotherapy, Dietetics and Occupational Therapy) for neuro-oncology patients has been a longstanding vision at Velindre Cancer Centre (VCC) in Cardiff. A successful funding application to Welsh Government in July 2020 allowed the establishment of a virtual “one stop shop” clinic with CNS and AHPs available along the care trajectory to improve patient and carer quality of life. The project reports on whether this innovative clinic model successfully achieved the desired coordinated, anticipatory and holistic care. Method The project utilised service improvement methodology principles with aims inherent within quarterly timeframes. This included robust data collection on patient attendances and interventions, improving patient education and self-management and wide patient, care and staff engagement by means of questionnaires and semi-structured interviews. The mixed methods approach yielded rich quantitative and qualitative data. Results The data demonstrates an increasing demand for the joint neuro-oncology clinic indicating that additional resources may be required. From triangulation of patient, carer and wider team engagement the key benefits were perceived to be having accessibility to the team in a convenient way, the provision of support and timely information and the overall perception of enhanced holistic care. Conclusion The data demonstrates the huge successes of the joint neuro-oncology clinic so far, including improvements to patient and carer quality of life, wider VCC benefits and cost saves. The persuasive case was presented to Welsh Government, and ongoing endorsement has been achieved for the next financial year.
The proteasome inhibitor PS-341 (Velcade) stabilizes the TRAIL receptor DR5 mRNA through the 3'-untranslated region
Authors: Karthikeyan Kandasamy, Andrew Kraft
Journal: Cancer Research (2008)

3353  Addition of proteasome inhibitors PS-341 (VELCADE, bortezomib) to prostate cancer cells enhances cell death mediated by TNF-related apoptosis-inducing ligand (TRAIL). PS-341 sensitizes prostate cancer cells to TRAIL-induced apoptosis by increasing TRAIL receptors (DR5), inhibiting protein degradation, and elevating DR5 mRNA. Investigations into how PS-341 regulates the stability of DR5 mRNA revealed that PS-341 increased DR5 mRNA by extending its half-life from 4 to 10 h. The 2.5-kb 3′-untranslated region (UTR) of the DR5 gene stabilized a heterologous gene in LNCaP human prostate cancer cells, suggesting the importance of this mRNA sequence. In contrast, human prostate cancer cell lines PC-3 and DU145 do not show this stabilization, suggesting cell specificity. PS-341 treatment of LNCaP cells increases specific cytoplasmic mRNA binding proteins, including AUF-1 isoforms, hnRNP C1/C2, and HuR proteins. In UV cross-linking experiments, after PS-341 treatment, the HuR protein markedly increases binding to specific sequences in the DR5 3′-UTR. In LNCap cells treated with PS-341, siRNA-mediated knockdown of HuR markedly decreases the half-life of DR5 mRNA, indicating that HuR is essential for mRNA stabilization. HuR protein is ubiquitinated, suggesting that PS-341 increases this protein by preventing its degradation. These experiments implicate modulation of mRNA stability as a novel mechanism by which proteasome inhibitors function, sensitizing cancer cells to anti-neoplasmic agents.
A medicinal chemist who reshaped the antiviral drug industry: John Charles Martin (1951–2021)
Authors: Guangdi Li, Erik De Clercq
Journal: Medicinal Research Reviews (2021)

John Charles Martin should be remembered as a visionary medicinal chemist who was involved in the coinvention, development, or management of many FDA-approved antiviral drugs such as ganciclovir, stavudine, didanosine, cidofovir, oseltamivir, adefovir dipivoxil, tenofovir disoproxil fumarate, tenofovir alafenamide, sofosbuvir, and remdesivir.
MA14.02 RET Fusion Testing in Advanced Non-Small Cell Lung Carcinoma Patients: the RETING Study
Authors: E. Conde, S. Hernandez, A. Caminoa, A. Benito, R. Martinez, M. Alonso, B. Jimenez, V. Boni, J. Remon, L. Pijuan, S. Clave, E. Arriola, I. Esteban, J. De Castro, I. Sansano, E. Felip, I. Abdulkader, J. Garcia, F. Rojo, M. Domine, C. Teixido, N. Reguart, D. Compañ, A. Insa, N. Mancheño, S. Palanca, O. Juan, N. Baixeras, E. Nadal, M. Cebollero, A. Calles, P. Martin, C. Salas, M. Provencio, I. Aranda, B. Massuti, L. Lopez-Vilaro, M. Majem, A.B. Enguita, L. Paz-Ares, P. Garrido, F. Lopez-Rios
Journal: Journal of Thoracic Oncology (2021)
Digital connections to improve India’s health
Authors: Surajit Nundy
Journal: BMJ (2021)

Healthcare in India has long been provided in unconnected silos by individual doctors and in small hospitals. Care is typically initiated by patients who seek treatment in the private sector for which they pay providers an “out-of-pocket” fee.1 Most patients receive either printed or short, hastily handwritten summaries of their care. This serves to tie patients to the provider who knows them, but it means that when they do happen to move and seek another provider there are no reliable means of transferring information.

As a healthcare provider I often have to redo blood tests and even re-administer drugs because there are no shared electronic records, paper records may be incomplete or hard to interpret, and I can’t always rely on a patient’s memory. Because of the lack of information patients have little choice but to agree with providers’ management decisions. These duplicate and redundant care practices not only contribute to unnecessary costs for patients but increase avoidable harm and leave people feeling ignored and disconnected from the healthcare system.

Public sector providers (those paid by private insurance) have some interest in reducing …
P24.03 Dynamic Circulating Tumor DNA Interim Results From The ALKternate Clinical Trial
Authors: M. Itchins, S. Liang, T. Barnes, G. Marx, V. Chin, S. Kao, P.Y. Yip, A. Nagrial, G. Peters, V. Bray, C. Lewis, T. Shaffer, M. Li, S. Clarke, B. Li, C. Brown, B. Solomon, N. Pavlakis
Journal: Journal of Thoracic Oncology (2021)
Rather than championing a medical model of assisted dying,<i>The BMJ</i>should be challenging the underlying discriminatory assumptions
Authors: H Lucy Thomas
Journal: BMJ (2021)

Godlee calls on professional organisations to adopt a neutral stance on assisted dying as it is “a decision for society and parliament to make.”12 But she uses her position to champion a profoundly medicalised model of assisted dying and does not address the implications for patients, doctors, and society.2

Consistent evidence shows that the desire to hasten death by people with terminal illnesses is unstable and heavily influenced by social, …
P66.08 Differential Expression of INSM1 Between Pure SCLC and LCNEC After Surgical Resection and Its Clinicopathological Significance
Authors: Y. Cao, L. Liu, J. Dong, J. Zhang, Y. Guo, X. Sun, X. Wang, J. Ying, P. Xing, J. Li, L. Yang
Journal: Journal of Thoracic Oncology (2021)
Gastric cancer incidence and mortality trends 2007–2016 in three European countries
Authors: Diogo Libânio, Jessica R. Rodrigues, Maria J. Bento, Alanna Ebigbo, Helmut Messman, Rob H.A. Verhoeven, Nancy Van Damme, Raf Bisschops, Manon C.W. Spaander, Marío Dinis-Ribeiro
Journal: Endoscopy (2021)

BACKGROUND : Increased awareness of gastric cancer risk, easy access to upper endoscopy, and high definition endoscopes with virtual chromoendoscopy may have led to the increase in early diagnosis of gastric cancer observed in recent years in Europe, which may be associated with improved survival. Currently, no data exist on the impact of early diagnosis on survival at a populational level in Europe. Our aim was to assess gastric cancer incidence, early diagnosis, and survival in northwestern and southern European countries with a low-to-moderate incidence of gastric cancer. METHODS : Data on 41 138 gastric cancers diagnosed in 2007-2016 were retrieved from national cancer registries of Belgium, the Netherlands, and northern Portugal. Age-standardized incidence and mortality rates were assessed and expressed per 100 000 person-years. Early diagnosis was defined as T1 tumors. Net survival estimates for 2007-2011 vs. 2012-2016 were compared. RESULTS : Age-standardized incidence and mortality decreased over time in Belgium, northern Portugal, and the Netherlands (relative incidence decrease 8.6 %, 4.5 %, and 46.8 %, respectively; relative mortality decrease 22.0 %, 30.9 %, and 50.0 %, respectively). Early gastric cancer diagnosis increased over time for all countries. Net 1-year survival improved significantly between the two time periods in all countries, and at 5 years in Belgium and Portugal. CONCLUSIONS : This is the first study comparing trends (2007-2016) in gastric cancer incidence and mortality in some European countries. We found an increasing proportion of T1 gastric cancers and a decrease in age-standardized mortality over time, supporting the use of secondary prevention strategies.
Aged healthy mice acquire clonal hematopoiesis mutations
Authors: Desmond Wai Loon Chin, Tetsuichi Yoshizato, Stina Virding Culleton, Francesca Grasso, Magdalena Barbachowska, Seishi Ogawa, Sten Eirik W. Jacobsen, Petter S. Woll
Journal: Blood (2021)

Chin and colleagues used detailed mutational analysis of aged mice and transplantation to evaluate the mouse as a model of clonal hematopoiesis (CH). Their data suggest that while murine hematopoietic stem cells acquire mutations in CH-associated genes when aged and CH clones can expand after transplantation (as in humans), these are rare events. Nevertheless, genetically manipulated murine models mimicking human CH are feasible and may prove useful in the future.
Neutrophil extracellular traps: from physiology to pathology
Authors: Andres Hidalgo, Peter Libby, Oliver Soehnlein, Iker Valle Aramburu, Venizelos Papayannopoulos, Carlos Silvestre-Roig
Journal: Cardiovascular Research (2021)

Abstract At the frontline of the host defence response, neutrophil antimicrobial functions have adapted to combat infections and injuries of different origins and magnitude. The release of web-like DNA structures named neutrophil extracellular traps (NETs) constitutes an important mechanism by which neutrophils prevent pathogen dissemination or deal with microorganisms of a bigger size. At the same time, nuclear and granule proteins with microbicidal activity bind to these DNA structures promoting the elimination of entrapped pathogens. However, these toxic properties may produce unwanted effects in the host, when neutrophils uncontrollably release NETs upon persistent inflammation. As a consequence, NET accumulation can produce vessel occlusion, tissue damage, and prolonged inflammation associated with the progression and exacerbation of multiple pathologic conditions. This review outlines recent advances in understanding the mechanisms of NET release and functions in sterile disease. We also discuss mechanisms of physiological regulation and the importance of neutrophil heterogeneity in NET formation and composition.
Higher Mortality Risk Among Transgender People
Authors: Bridget M. Kuehn
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MA16.06 Durvalumab ± Tremelimumab + Platinum-Etoposide in 1L ES-SCLC: Exploratory Analysis of HLA Genotype and Survival in CASPIAN
Authors: M.C. Garassino, Y. Shrestha, M. Xie, Z. Lai, S. Spencer, T. Dalvi, L. Paz-Ares
Journal: Journal of Thoracic Oncology (2021)
OA01.01 Analysis of Lung Cancer Patients Receiving SARS-CoV-2 Vaccines Revealed a Minority Subset With Poor Antibody Responses Relative to Controls
Authors: J. Gomez, F. Krammer, P. Mack, C. Rolfo, N. Rohs, A. Moore, J. King, C. Henschke, D. Yankelevitz, Y. Shyr, E. Taioli, B. Fontoura, R. Brody, D. Gerber, J. Minna, P.A. Bunn, A. Garcia-Sastre, F. Hirsch
Journal: Journal of Thoracic Oncology (2021)
Zanubrutinib monotherapy in relapsed/refractory mantle cell lymphoma: a pooled analysis of two clinical trials
Authors: Keshu Zhou, Dehui Zou, Jianfeng Zhou, Jianda Hu, Haiyan Yang, Huilai Zhang, Jie Ji, Wei Xu, Jie Jin, Fangfang Lv, Ru Feng, Sujun Gao, Daobin Zhou, Constantine S. Tam, David Simpson, Michael Wang, Tycel J. Phillips, Stephen Opat, Zhiyue Huang, Huafei Lu, Yuqin Song, Yongping Song
Journal: Journal of Hematology & Oncology (2021)

Abstract Mantle cell lymphoma (MCL) is a mature B-cell neoplasm with a high initial response rate followed almost invariably by relapse. Here we report the pooled data from 2 studies, BGB-3111-AU-003 and BGB-3111-206, to explore the efficacy of zanubrutinib monotherapy in relapsed/refractory (R/R) MCL. A total of 112 patients were included. Median follow-up durations were 24.7 and 24.9 months for BGB-3111-AU-003 and BGB-3111-206, respectively. Overall response rate (ORR) and complete response (CR) rate were 84.8% and 62.5%, and median duration of response, progression-free survival (PFS) and overall survival (OS) were 24.9, 25.8 and 38.2 months, respectively. After weighting, the PFS (median: NE vs. 21.1 months, P = 0.235) and OS (median: NE vs. 38.2 months, P = 0.057) were similar but numerically better in the second-line than later-line group. Zanubrutinib was well-tolerated with treatment discontinuation and dose reduction for adverse events in 12.5% and 2.7% of patients, respectively. Hypertension, major hemorrhage and atrial fibrillation/flutter rates were 11.6%, 5.4% and 1.8%, respectively. Zanubrutinib is efficacious in R/R MCL, with a favorable safety profile.
低分子による腸内微生物代謝経路の標的化は尿毒症毒素産生を減少させる【JST・京大機械翻訳】
Authors: Wang Yingyi, Li Jianping, Chen Chenkai, Lu Jingbo, Yu Jingao, Xu Xuejun, Peng Yin, Zhang Sen, Jiang Shu, Guo Jianming, Duan Jinao
Journal: Gut Microbes (2020)
Team debriefings in healthcare: drawing on the strengths of other professions
Authors: Charlotte Miles, Harry Bark
Journal: BMJ (2021)

As a foundation doctor and newly qualified social worker, we value Kolbe and colleagues’ recent piece on debriefing in healthcare.1 The article points out that difficult situations often trigger non-specific (or “vague”) debrief needs, which are tackled after proactive requests for debriefing from staff. Such a model places the onus on individuals in the healthcare team to seek support.

It …
Progress in the Management of Pancreatic Neuroendocrine Tumors
Authors: Amy Chang, Scott K. Sherman, James R. Howe, Vaibhav Sahai
Journal: Annual Review of Medicine (2021)

Pancreatic neuroendocrine tumors (PNETs) are a heterogeneous and orphan group of neoplasms that vary in their histology, clinical features, prognosis, and management. The treatment of PNETs is highly dependent on the stage at presentation, tumor grade and differentiation, presence of symptoms from hormonal overproduction or from local growth, tumor burden, and rate of progression. The US Food and Drug Administration has recently approved many novel treatments, which have altered decision making and positively impacted the care and prognosis of these patients. In this review, we focus on the significant progress made in the management of PNETs over the past decade, as well as the active areas of research.
Racial Disparities in Child Abuse Medicine
Authors: Cameron M. Rosenthal, Donna M. Parker, Lindsay A. Thompson
Journal: JAMA Pediatrics (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
P06.10 Low-Cost Video-Assisted Thoracic Surgery (VATS) Lobectomy Versus Regular VATS Lobectomy: A Propensity-Matched Study
Authors: T. Liuru, D. Pang, F.M. Kong, J. Zhang, G. Shao, Y. Xu, Z. Liu, Y. Liang, M. Zhu
Journal: Journal of Thoracic Oncology (2021)
Tachycardia-Dependent Paroxysmal Atrioventricular Block
Authors: Laszlo Littmann
Journal: JAMA Internal Medicine (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Targeting CDC7 potentiates ATR-CHK1 signaling inhibition through induction of DNA replication stress in liver cancer
Authors: Yuchen Guo, Jun Wang, Bente Benedict, Chen Yang, Frank van Gemert, Xuhui Ma, Dongmei Gao, Hui Wang, Shu Zhang, Cor Lieftink, Roderick L. Beijersbergen, Hein te Riele, Xiaohang Qiao, Qiang Gao, Chong Sun, Wenxin Qin, René Bernards, Cun Wang
Journal: Genome Medicine (2021)

Abstract Background Liver cancer is one of the most commonly diagnosed cancers and the fourth leading cause of cancer-related death worldwide. Broad-spectrum kinase inhibitors like sorafenib and lenvatinib provide only modest survival benefit to patients with hepatocellular carcinoma (HCC). This study aims to identify novel therapeutic strategies for HCC patients. Methods Integrated bioinformatics analyses and a non-biased CRISPR loss of function genetic screen were performed to identify potential therapeutic targets for HCC cells. Whole-transcriptome sequencing (RNA-Seq) and time-lapse live imaging were performed to explore the mechanisms of the synergy between CDC7 inhibition and ATR or CHK1 inhibitors in HCC cells. Multiple in vitro and in vivo assays were used to validate the synergistic effects. Results Through integrated bioinformatics analyses using the Cancer Dependency Map and the TCGA database, we identified ATR-CHK1 signaling as a therapeutic target for liver cancer. Pharmacological inhibition of ATR or CHK1 leads to robust proliferation inhibition in liver cancer cells having a high basal level of replication stress. For liver cancer cells that are resistant to ATR or CHK1 inhibition, treatment with CDC7 inhibitors induces strong DNA replication stress and consequently such drugs show striking synergy with ATR or CHK1 inhibitors. The synergy between ATR-CHK1 inhibition and CDC7 inhibition probably derives from abnormalities in mitosis inducing mitotic catastrophe. Conclusions Our data highlights the potential of targeting ATR-CHK1 signaling, either alone or in combination with CDC7 inhibition, for the treatment of liver cancer.
OA09.01 First-line Nivolumab + Ipilimumab + Chemo in Patients With Advanced NSCLC and Brain Metastases: Results From CheckMate 9LA
Authors: D. Carbone, T. Ciuleanu, M. Cobo, M. Schenker, B. Zurawski, J. Menezes, E. Richardet, J. Bennouna, E. Felip, O. Juan-Vidal, A. Alexandru, H. Sakai, E. De La Mora Jimenez, L. Paz-Ares, M. Reck, T. John, N. Hu, X. Zhang, P. Tran, D.J. Grootendorst, S. Lu
Journal: Journal of Thoracic Oncology (2021)
Correction: A unique technique for the removal of threaded biliary inside plastic stents
Authors: Masataka Yokode, Tomoaki Matsumori, Norimitsu Uza, Hirokazu Okada, Takeshi Kuwada, Masahiro Shiokawa, Hiroshi Seno
Journal: Endoscopy (2021)

Correction to: A unique technique for the removal of threaded biliary inside plastic stentsEndoscopy eFirstDOI: 10.1055/a-1640-8829
OA17.03 Depression, Anxiety, and Distress Impact in Patients With Thoracic Malignancies During the COVID-19 Pandemic
Authors: O. Arrieta, E. Bautista-González, J. Turcott, L. Lara-Mejía, D. Heredia, F. Barrón, M. Ramos-Ramirez, L. Cabrera Miranda, M. Salinas, M. Aguerrebere, A. Cardona Zorrilla, C. Rolfo, M. Arroyo Hernandez, E. Soto, R. Báez-Saldaña
Journal: Journal of Thoracic Oncology (2021)