tbuckley/cabot-search huggingface dataset:
HSR21-047: Tumor Lysis Syndrome Risk Analysis in a US Community Oncology Setting: A Retrospective Observational Study in Integra Connect Network
Authors: Kaustav Chatterjee, Edward Drea, Robert Smith, Mei Xue, Hunter Lambert, Jeffrey Scott, Sorena Nadaf, Simon Blanc, Prateesh Varughese, John Verniero
Journal: Journal of the National Comprehensive Cancer Network (2021)

"HSR21-047: Tumor Lysis Syndrome Risk Analysis in a US Community Oncology Setting: A Retrospective Observational Study in Integra Connect Network" published on 17 Mar 2021 by National Comprehensive Cancer Network.
Myocarditis Surveillance With High-Sensitivity Troponin I During Cancer Treatment With Immune Checkpoint Inhibitors
Authors: Sarah Waliany, Joel W Neal, Sunil Reddy, Heather Wakelee, Sumit A Shah, Sandy Srinivas, Sukhmani K Padda, Alice C Fan, A Dimitrios Colevas, Sean M Wu, Ronald M Witteles, Han Zhu
Journal: JACC CardioOncology (2021)
Abstract 16812: ETV2- <i>Rhoj</i> Cascade Regulates Endothelial Progenitor Cell Migration During Embryogenesis
Authors: Javier Sierra-Pagan, BHAIRAB N SINGH, Wuming Gong, Satyabrata Das, Erik Skie, Mary G Garry, Daniel J Garry
Journal: Circulation (2020)

Background: Endothelial progenitors migrate early during embryogenesis to form the primary vascular plexus. ETV2, an Ets-transcription factor, governs the specification of the earliest hemato-endothelial progenitors during embryogenesis. The regulatory mechanisms that govern their migration are undefined. In the present study, we describe a novel role for ETV2 in cell migration and provide evidence for an ETV2 -Rhoj network as a mechanism responsible for this process. Approach and Results: We analyzed our RNAseq datasets, which revealed robust enrichment of migratory/motility pathways following overexpression of ETV2 during mesodermal differentiation. We then analyzed ETV2 ChIPseq and ATACseq datasets, which showed enrichment of ChIPseq peaks with increased chromatin accessibility in migratory genes following overexpression of ETV2. Additionally, scratch and sprouting assays showed that overexpression of ETV2 enhanced cell migration in mouse embryonic stem cells (ESCs), embryoid bodies (EBs) and mouse embryonic fibroblasts (MEFs). Knockout of Etv2 led to migratory defects of Etv2-EYFP + angioblasts to their pre-defined regions of developing embryos relative to wildtype controls at embryonic day (E) 8.5, supporting its role during migration. Mechanistically, we showed that ETV2 binds to the promoter region of Rhoj serving as an upstream regulator of cell migration. Single cell RNAseq analysis of Etv2-EYFP + sorted cells revealed co-expression of Etv2 and Rhoj in endothelial progenitors at E7.75 and E8.25. Overexpression of ETV2 led to a robust increase in Rhoj in both EBs and MEFs, whereas, its expression was abolished in the Etv2 knockout EBs. Finally, shRNA-mediated knockdown of Rhoj resulted in migratory defects which were rescued by overexpression of ETV2. Conclusions: These results define an ETV2 -Rhoj cascade, which is important for the regulation of endothelial progenitor cell migration during embryogenesis.
P38.15 Interactive Genes Between Tumor Immune Microenvironment and Epithelial-Mesenchymal Transition During Lung Cancer Metastasis
Authors: X. Chen, Q. Bu, X. Yan, Y. Li, Q. Yu, H. Zheng, L. Zhao, Y. Zeng, Z. Song, D. Lan, J. Ma
Journal: Journal of Thoracic Oncology (2021)
OA10.03 Reporting of Tobacco Use and Impact on Outcomes in Cancer Cooperative Group Clinical Trials: A Systematic Scoping Review
Authors: L. Eng, J. Brual, A. Nagee, S. Mok, R. Fazelzad, M. Chaiton, D. Saunders, N. Mittmann, R. Truscott, G. Liu, P. Bradbury, W.K. Evans, J. Papadakos, M. Giuliani
Journal: Journal of Thoracic Oncology (2021)
The Interstate Medical Licensure Compact
Authors: Eli Y. Adashi, I. Glenn Cohen, Winston L. McCormick
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HSR21-050: Access to Gastroenterology and Internal Medicine Physicians is Associated With Improved Outcomes in Colorectal Cancer: A Nation-Wide Analysis
Authors: Udhayvir Singh Grewal, Subhash Chandra Garikipati, Parth Rajeshbhai Shah, Shiva Jashwanth Gaddam, Aakash Rajendra Sheth, Ghanshyam Mudigonda
Journal: Journal of the National Comprehensive Cancer Network (2021)

"HSR21-050: Access to Gastroenterology and Internal Medicine Physicians is Associated With Improved Outcomes in Colorectal Cancer: A Nation-Wide Analysis" published on 17 Mar 2021 by National Comprehensive Cancer Network.
Abstract 10987: Impact of Epicardial Adipose Tissue on Coronary Atherosclerotic Plaque of Nonculprit Lesions in Patients with Acute Coronary Syndrome: Analysis by Integrated Backscatter Intravascular Ultrasound
Authors: Kazuhiro Harada, Ken Harada, Tadayuki Uetani, Masataka Kato, Bunichi Kato, Tomohiro Yoshida, Yusaku Shimbo, Ayako Kunimura, Akihiro Suzuki, Katsuhide Kitagawa, Hirohiko Ando, Tetsuya Amano, Hideki Ishii, Tatsuaki Matsubara, Toyoaki Murohara
Journal: Circulation (2012)

Background: Epicardial fat volume (EFV) is increased in patients with acute coronary syndrome (ACS), and lipid-rich plaques have been associated with acute coronary events. Objective: To investigat...
P60.12 Baseline Tumor Immune Cell Infiltration and Activation can Predict Checkpoint Inhibitor Pneumonitis in Lung Cancer Patients
Authors: J. Bracht, S. Viteri, A. Aguilar, J.J. Garcia, C. Huang, N. Potie, E. Aldeguer, A. Giménez-Capitán, S. Rodriguez, R. Roman, S. Warren, R. Rosell, M.A. Molina-Vila, M. González-Cao
Journal: Journal of Thoracic Oncology (2021)
Neurohormonal inhibitors: Discussion VII
Authors: M. Packer, C. R. Benedict, R. J. Cody, J. N. Cohn, U. Elkayam, G. H. Guyatt, A. M. Katz, M. A. Pfeffer, B. Pitt, E. H. Sonnenblick, S. Yusuf
Journal: Journal of the American College of Cardiology (1993)
OA05.06 Lessons Learned from the Victorian Lung Cancer Registry: Opportunities for Quality Improvement in Lung Cancer Management and Outcomes
Authors: R. Stirling, M. Brand, A. Earnest, P. Antippa, D. Ball, J. Bartlett, R. Blum, L. Briggs, M. Caldecott, M. Conron, B. Jennings, D. Langton, J. Millar, P. Mitchell, I. Olesen, P. Parente, G. Richardson, K. See, J. Torres, C. Underhill, G. Wright, M. Stenger, J. Mcneil, J. Zalcberg
Journal: Journal of Thoracic Oncology (2021)
P87.04 Chemotherapy and Immunotherapy Outcomes of RET-Rearranged Lung Cancers: A Case Series
Authors: E. Rodriguez, R. Dawar, K. Gawri, V. Thammineni, T. Torres, D. Fanfan, E. Saul, C. Ikpeazu, G. Lopes
Journal: Journal of Thoracic Oncology (2021)
P76.50 Analysis of Efficacy and Safety of First Generation EGFR-TKI plus Apatinib in Treating Advanced NSCLC after EGFR-TKI Treatment Failure
Authors: Y. Feng, H. Zhu, X. Hu, Y. Liu, P. Xing, H. Wang, X. Ji, Z. Dai, Y. Shi
Journal: Journal of Thoracic Oncology (2021)
Annals Graphic Medicine - Dr. Mom: Annual Review
Authors: Grace E. Farris
Journal: Annals of Internal Medicine (2021)

Web ExclusivesApril 2021Annals Graphic Medicine - Dr. Mom: Annual ReviewFREEGrace E. Farris, MDGrace E. Farris, MDUniversity of Texas, Austin, Texas (G.E.F.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/G21-0016 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Download figure Download PowerPoint Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: University of Texas, Austin, Texas (G.E.F.)Disclosures: The author has reported no disclosures of interest. The form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=G18-0042.Author/Illustrator Information: Grace E. Farris, MD, is an assistant professor of medicine at Dell Medical School at the University of Texas in Austin, Texas. You can view her work at her website: www.farrisgrace.com.About Dr. Mom: In Dr. Mom, physician and cartoonist Grace Farris examines work–life balance while mothering and doctoring. Dr. Mom appears monthly in Annals Graphic Medicine at Annals.org.This article was published at Annals.org on 23 March 2021. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics April 2021Volume 174, Issue 4Page: W35-W36 ePublished: 23 March 2021 Issue Published: April 2021 Copyright & PermissionsCopyright © 2021 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
An Examination of National Cancer Risk Based on Monitored Hazardous Air Pollutants
Authors: Chelsea A. Weitekamp, McKayla Lein, Madeleine Strum, Mark Morris, Ted Palma, Darcie Smith, Lukas Kerr, Michael J. Stewart
Journal: Environmental Health Perspectives (2021)

Hazardous air pollutants, or air toxics, are pollutants known to cause cancer or other serious health effects. Nationwide cancer risk from these pollutants is estimated by the U.S. EPA National Air Toxics Assessment. However, these model estimates are limited to the totality of the emissions inventory used as inputs, and further, they cannot be used to examine spatial and temporal trends in cancer risk from hazardous air pollutants.To complement model estimates of nationwide cancer risk, we examined trends in cancer risk using monitoring data from 2013 to 2017 across the 27 U.S. National Air Toxics Trends Stations.For each monitoring site, we estimated cancer risk by multiplying the annual concentration for each monitored pollutant by its corresponding unit risk estimate. We examined the 5-y average (2013-2017) cancer risk across sites and the population levels and demographics within 1-mi of the monitors, as well as changes in estimated cancer risk over time. Finally, we examined changes in individual pollutant concentrations and their patterns of covariance.We found that the total estimated cancer risk is higher for urban vs. rural sites, with the risk at seven urban sites (of 21) above 75 in 1 million. Furthermore, while most pollutant concentrations have not changed over the time period explored, we found 38 site-pollutant combinations that significantly declined and 12 that significantly increased between 2013 and 2017. We also identified a positive correlation between estimated cancer risk and percent of the population within 1-mi of a monitor that is low income.Long-term trends show that annual mean concentrations of most measured air toxics have declined. Our evaluation of a more recent snapshot in time finds that most pollutant concentrations have not changed from 2013 to 2017. This analysis of cancer risk based on monitored values provides an important complement to modeled nationwide cancer risk estimates and can further inform future approaches to mitigate risk from exposure to hazardous air pollutants. https://doi.org/10.1289/EHP8044.
N-cadherin upregulation mediates adaptive radioresistance in glioblastoma
Authors: Satoru Osuka, Dan Zhu, Zhaobin Zhang, Chaoxi Li, Christian T. Stackhouse, Oltea Sampetrean, Jeffrey J. Olson, G. Yancey Gillespie, Hideyuki Saya, Christopher D. Willey, Erwin G. Van Meir
Journal: Journal of Clinical Investigation (2021)

Glioblastoma (GBM) is composed of heterogeneous tumor cell populations, including those with stem cell properties, termed glioma stem cells (GSCs). GSCs are innately less radiation sensitive than the tumor bulk and are believed to drive GBM formation and recurrence after repeated irradiation. However, it is unclear how GSCs adapt to escape the toxicity of repeated irradiation used in clinical practice. To identify important mediators of adaptive radioresistance in GBM, we generated radioresistant human and mouse GSCs by exposing them to repeat cycles of irradiation. Surviving subpopulations acquired strong radioresistance in vivo, which was accompanied by a reduction in cell proliferation and an increase in cell-cell adhesion and N-cadherin expression. Increasing N-cadherin expression rendered parental GSCs radioresistant, reduced their proliferation, and increased their stemness and intercellular adhesive properties. Conversely, radioresistant GSCs lost their acquired phenotypes upon CRISPR/Cas9-mediated knockout of N-cadherin. Mechanistically, elevated N-cadherin expression resulted in the accumulation of β-catenin at the cell surface, which suppressed Wnt/β-catenin proliferative signaling, reduced neural differentiation, and protected against apoptosis through Clusterin secretion. N-cadherin upregulation was induced by radiation-induced IGF1 secretion, and the radiation resistance phenotype could be reverted with picropodophyllin, a clinically applicable blood-brain-barrier permeable IGF1 receptor inhibitor, supporting clinical translation.
P44.05 Bone Density Measures Out-Perform Clinical Risk Scores in Detection of Vertebral Fractures in a Lung Cancer Screening Cohort
Authors: N. Patel, K. Hopcraft, R. O'Rourke, A. Williamson, P. Georgiou, I. Yang, K. Fong, H. Marshall
Journal: Journal of Thoracic Oncology (2021)
P34.07 Quantification of BIM mRNA In Circulating Tumor Cells Of Osimertinib-treated Patients with EGFR Mutation-positive Lung Cancer
Authors: K. Isobe, H. Kobayashi, T. Isshiki, S. Sakamoto, Y. Takai, T. Tomida, S. Adachi-Akahane, K. Kishi
Journal: Journal of Thoracic Oncology (2021)
Remodelling of adult cardiac tissue subjected to physiological and pathological mechanical load <i>in vitro</i>
Authors: Fotios G Pitoulis, Raquel Nunez-Toldra, Ke Xiao, Worrapong Kit-Anan, Saskia Mitzka, Richard J Jabbour, Sian E Harding, Filippo Perbellini, Thomas Thum, Pieter P de Tombe, Cesare M Terracciano
Journal: Cardiovascular Research (2021)

Cardiac remodelling is the process by which the heart adapts to its environment. Mechanical load is a major driver of remodelling. Cardiac tissue culture has been frequently employed for in vitro studies of load-induced remodelling; however, current in vitro protocols (e.g. cyclic stretch, isometric load, and auxotonic load) are oversimplified and do not accurately capture the dynamic sequence of mechanical conformational changes experienced by the heart in vivo. This limits translational scope and relevance of findings.We developed a novel methodology to study chronic load in vitro. We first developed a bioreactor that can recreate the electromechanical events of in vivo pressure-volume loops as in vitro force-length loops. We then used the bioreactor to culture rat living myocardial slices (LMS) for 3 days. The bioreactor operated based on a 3-Element Windkessel circulatory model enabling tissue mechanical loading based on physiologically relevant parameters of afterload and preload. LMS were continuously stretched/relaxed during culture simulating conditions of physiological load (normal preload and afterload), pressure-overload (normal preload and high afterload), or volume-overload (high preload & normal afterload). At the end of culture, functional, structural, and molecular assays were performed to determine load-induced remodelling. Both pressure- and volume-overloaded LMS showed significantly decreased contractility that was more pronounced in the latter compared with physiological load (P < 0.0001). Overloaded groups also showed cardiomyocyte hypertrophy; RNAseq identified shared and unique genes expressed in each overload group. The PI3K-Akt pathway was dysregulated in volume-overload while inflammatory pathways were mostly associated with remodelling in pressure-overloaded LMS.We have developed a proof-of-concept platform and methodology to recreate remodelling under pathophysiological load in vitro. We show that LMS cultured in our bioreactor remodel as a function of the type of mechanical load applied to them.
Pleiotropic consequences of metabolic stress for the major histocompatibility complex class II molecule antigen processing and presentation machinery
Authors: Cristina C. Clement, Padma P. Nanaware, Takahiro Yamazaki, Maria Pia Negroni, Karthik Ramesh, Kateryna Morozova, Sangeetha Thangaswamy, Austin Graves, Hei Jung Kim, Tsai Wanxia Li, Marco Vigano’, Rajesh K. Soni, Massimo Gadina, Harley Y. Tse, Lorenzo Galluzzi, Paul A. Roche, Lisa K. Denzin, Lawrence J. Stern, Laura Santambrogio
Journal: Immunity (2021)
P76.67 Safety and Efficacy of First-Line Dacomitinib in Advanced Non-Small Cell Lung Cancer by EGFR Mutation SUBtype in ARCHER 1050
Authors: A. Pluzanski, Y. Wu, Y. Cheng, X. Zhou, M.R. Migliorino, S. Niho, K. Nakagawa, K.H. Lee, J. Corral, R. Rosell, R. Linke, Y. Tang, M. Pastel, K. Wilner, T. Mok
Journal: Journal of Thoracic Oncology (2021)
Abstract 15871: Gender Differences in the Prognostic Impact of Echocardiographic Indices and Bnp Levels in the Community-Based Population
Authors: Takuya Hasegawa, Masanori Asakura, Mari Sakamoto, Yasuhiro Hamatani, Masashi Amano, Atsushi Okada, Makoto Amaki, Hiroyuki Takahama, Hideaki Kanzaki, Satoshi Yasuda, Chisato Izumi, Masafumi Kitakaze
Journal: Circulation (2019)

Background: Ventricular-vascular coupling is more pronounced in elderly women, which is considered as a plausible mechanism of the greater risk of heart failure with preserved ejection fraction (HF...
EVI1 dysregulation: impact on biology and therapy of myeloid malignancies
Authors: Christine Birdwell, Warren Fiskus, Tapan M. Kadia, Courtney D. DiNardo, Christopher P. Mill, Kapil N. Bhalla
Journal: Blood Cancer Journal (2021)

Abstract Ecotropic viral integration site 1 ( Evi1 ) was discovered in 1988 as a common site of ecotropic viral integration resulting in myeloid malignancies in mice. EVI1 is an oncogenic zinc-finger transcription factor whose overexpression contributes to disease progression and an aggressive phenotype, correlating with poor clinical outcome in myeloid malignancies. Despite progress in understanding the biology of EVI1 dysregulation, significant improvements in therapeutic outcome remain elusive. Here, we highlight advances in understanding EVI1 biology and discuss how this new knowledge informs development of novel therapeutic interventions. EVI1 is overexpression is correlated with poor outcome in some epithelial cancers. However, the focus of this review is the genetic lesions, biology, and current therapeutics of myeloid malignancies overexpressing EVI1.
The WW domains dictate isoform-specific regulation of YAP1 stability and pancreatic cancer cell malignancy: Erratum
Authors: Qiang Guo, Meiyu Quan, Jinglai Dong, Jing Bai, Jie Wang, Rui Han, Wei Wang, Yaxin Cai, Yu-Qing Lv, Qianjie Chen, Huijing Xu, Han-Deng Lyu, Liancheng Deng, Depu Zhou, Xueyuan Xiao, Stijn De Langhe, Daniel D Billadeau, Zhenkun Lou, Jin-San Zhang
Journal: Theranostics (2020)

[This corrects the article DOI: 10.7150/thno.42795.].
Electroacupuncture ameliorates intestinal inflammation by activating α7nAChR-mediated JAK2/STAT3 signaling pathway in postoperative ileus
Authors: Na-Na Yang, Jing-Wen Yang, Yang Ye, Jin Huang, Lu Wang, Yu Wang, Xin-Tong Su, Ying Lin, Fang-Ting Yu, Si-Ming Ma, Ling-Yu Qi, Lu-Lu Lin, Li-Qiong Wang, Guang-Xia Shi, Hong-Ping Li, Cun-Zhi Liu
Journal: Theranostics (2021)

Inflammatory cytokines produced by muscularis macrophages largely contribute to the pathological signs of postoperative ileus (POI). Electroacupuncture (EA) can suppress inflammation, mainly or partly via activation of vagal efferent. The goal of this study was to investigate the mechanisms by which EA stimulation at an hindlimb region ameliorates inflammation in POI. Methods: Intestinal motility and inflammation were examined after 24 h after intestinal manipulation (IM)-induced POI in mice. Local immune response in the intestinal muscularis, expression of macrophages, α7 nicotinic acetylcholine receptor (α7nAChR), Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) were determined by flow cytometry, Western Blot, qPCR and immunofluorescence. The effects of α7nAChR antagonists (methyllycaconitine and α-bungarotoxin) and JAK2/STAT3 inhibitors (AG490 and WP1066) were also administered in a subset of mice prior to EA. In the parasympathetic pathways, intestinal motility and inflammation were determined after cervical vagotomy and sub-diaphragmatic vagotomy. The expression of gamma absorptiometry aminobutyric acid (GABAA) receptor in dorsal motor nucleus of vagal (DMV) cholinergic neurons was assessed by immunofluorescence and the response to DMV microinjection of bicuculine (antagonist of GABAA receptor) or muscimol (agonist of GABAA receptor) were assessed. Results: EA suppressed intestinal inflammation and promoted gastrointestinal motility. Mechanistically, EA activated the α7nAChR-mediated JAK2/STAT3 signaling pathway in macrophages which reduced the production of inflammatory cytokines. Furthermore, we also demonstrated that hindlimb region stimulation drove vagal efferent output by inhibiting the expression of GABAA receptor in DMV to ameliorate inflammation. Conclusions: The present study revealed that EA of hindlimb regions inhibited the expression of GABAA receptor in DMV neurons, whose excited vagal nerve, in turn suppressed IM-induced inflammation via activation of α7nAChR-mediated JAK2/STAT3 signaling pathway.