tbuckley/cabot-search huggingface dataset:
Immune system and intestinal microbiota determine efficacy of androgen deprivation therapy against prostate cancer
Authors: Safae Terrisse, Anne-Gaelle Goubet, Kousuke Ueda, Andrew Maltez Thomas, Valentin Quiniou, Cassandra Thelemaque, Garett Dunsmore, Emmanuel Clave, Melissa Gamat-Huber, Satoru Yonekura, Gladys Ferrere, Conrad Rauber, Hang Phuong Pham, Jean-Eudes Fahrner, Eugenie Pizzato, Pierre Ly, Marine Fidelle, Marine Mazzenga, Carolina Alves Costa Silva, Federica Armanini, Federica Pinto, Francesco Asnicar, Romain Daillère, Lisa Derosa, Corentin Richard, Pierre Blanchard, Bertrand Routy, Stéphane Culine, Paule Opolon, Aymeric Silvin, Florent Ginhoux, Antoine Toubert, Nicola Segata, Douglas G McNeel, Karim Fizazi, Guido Kroemer, Laurence Zitvogel
Journal: Journal for ImmunoTherapy of Cancer (2022)

Background Prostate cancer (PC) responds to androgen deprivation therapy (ADT) usually in a transient fashion, progressing from hormone-sensitive PC (HSPC) to castration-resistant PC (CRPC). We investigated a mouse model of PC as well as specimens from PC patients to unravel an unsuspected contribution of thymus-derived T lymphocytes and the intestinal microbiota in the efficacy of ADT. Methods Preclinical experiments were performed in PC-bearing mice, immunocompetent or immunodeficient. In parallel, we prospectively included 65 HSPC and CRPC patients (Oncobiotic trial) to analyze their feces and blood specimens. Results In PC-bearing mice, ADT increased thymic cellularity and output. PC implanted in T lymphocyte-depleted or athymic mice responded less efficiently to ADT than in immunocompetent mice. Moreover, depletion of the intestinal microbiota by oral antibiotics reduced the efficacy of ADT. PC reduced the relative abundance of Akkermansia muciniphila in the gut, and this effect was reversed by ADT. Moreover, cohousing of PC-bearing mice with tumor-free mice or oral gavage with Akkermansia improved the efficacy of ADT. This appears to be applicable to PC patients because long-term ADT resulted in an increase of thymic output, as demonstrated by an increase in circulating recent thymic emigrant cells (sjTRECs). Moreover, as compared with HSPC controls, CRPC patients demonstrated a shift in their intestinal microbiota that significantly correlated with sjTRECs. While feces from healthy volunteers restored ADT efficacy, feces from PC patients failed to do so. Conclusions These findings suggest the potential clinical utility of reversing intestinal dysbiosis and repairing acquired immune defects in PC patients.
Association between respiratory distress time and invasive mechanical ventilation in COVID-19 patients: A multicentre regional cohort study
Authors: S. Busani, I. Coloretti, M. Baciarello, V. Bellini, M. Sarti, E. Biagioni, R. Tonelli, A. Marchioni, E. Clini, G. Guaraldi, C. Mussini, M. Meschiari, T. Tonetti, L. Pisani, S. Nava, E. Bignami, M.V. Ranieri, M. Girardis
Journal: Pulmonology (2022)

To determine whether the duration of respiratory distress symptoms in severe COVID-19 pneumonia affects the need for invasive mechanical ventilation and clinical outcomes.
REMOTELY-DELIVERED MOTIVATIONAL INTERVIEWING-BASED COUNSELING IMPROVES DASH DIET ADHERENCE IN VETERANS WITH METABOLIC SYNDROME
Authors: Scott L. Hummel, Lauren E. Herty, Joanna M. Wells, Carly L. Runge, Shreya Chakravarthy, Margaret Scisney-Matlock
Journal: Journal of the American College of Cardiology (2022)
A NETWORK META-ANALYSIS OF 12,116 INDIVIDUALS FROM RANDOMIZED CONTROLLED TRIALS IN THE TREATMENT OF DEPRESSION AFTER ACUTE CORONARY SYNDROME
Authors: Shao Pin, Ansel Tang, Grace En Hui Lim, Yip Han Chin, Aaron Shengting Mai, Cheng Han Ng, Jie Ning Yong, Darren Tan, Phoebe Tay, Yu Yi Chan, Chloe Wen-Min Lee, Kamala Devi, Colin Eng Choon Ong, Roger SY Foo, Huay-Cheem Tan, Mark Y.Y. Chan, Roger Ho Chun Man, Poay-Huan Loh, Nicholas Ws Chew
Journal: Journal of the American College of Cardiology (2022)
TRANSCATHETER MITRAL VALVE REPAIR USING MITRACLIP WITH INTRA-AORTIC BALLOON PUMP SUPPORT IN THE SETTING OF CARDIOGENIC SHOCK
Authors: Krishna Suman Kallakuri, Rajeev L. Narayan, Benoit Bewley, Kamran Haleem, M. Zubair Jafar, Shalin Jitendra Patel
Journal: Journal of the American College of Cardiology (2022)
PI3K/AKT/mTOR signaling pathway activity in IDH-mutant diffuse glioma and clinical implications
Authors: Esraa Mohamed, Anupam Kumar, Yalan Zhang, Albert S Wang, Katharine Chen, Yunita Lim, Anny Shai, Jennie W Taylor, Jennifer Clarke, Stephanie Hilz, Mitchel S Berger, David A Solomon, Joseph F Costello, Annette M Molinaro, Joanna J Phillips
Journal: Neuro-Oncology (2022)

Abstract Background IDH-mutant diffuse gliomas are heterogeneous, and improved methods for optimal patient therapeutic stratification are needed. PI3K/AKT/mTOR signaling activity can drive disease progression and potential therapeutic inhibitors of the pathway are available. Yet, the prevalence of PI3K/AKT/mTOR signaling pathway activity in IDH-mutant glioma is unclear and few robust strategies to assess activity in clinical samples exist. Methods PI3K/AKT/mTOR signaling pathway activity was evaluated in a retrospective cohort of 132 IDH-mutant diffuse glioma (91 astrocytoma and 41 oligodendroglioma, 1p/19q-codeleted) through quantitative multiplex immunoprofiling using phospho-specific antibodies for PI3K/AKT/mTOR pathway members, PRAS40, RPS6, and 4EBP1, and tumor-specific anti-IDH1 R132H. Expression levels were correlated with genomic evaluation of pathway intrinsic genes and univariate and multivariate Cox proportional hazard regression models were used to evaluate the relationship with outcome. Results Tumor-specific expression of p-PRAS40, p-RPS6, and p-4EBP1 was common in IDH-mutant diffuse glioma and increased with CNS WHO grade from 2 to 3. Genomic analysis predicted pathway activity in 21.7% (13/60) while protein evaluation identified active PI3K/AKT/mTOR signaling in 56.6% (34/60). Comparison of expression in male versus female patients suggested sexual dimorphism. Of particular interest, when adjusting for clinical prognostic factors, the level of phosphorylation of RPS6 was strongly associated with PFS (P &amp;lt; .005). Phosphorylation levels of both PRAS40 and RPS6 showed an association with PFS in univariate analysis. Conclusions Our study emphasizes the value of proteomic assessment of signaling pathway activity in tumors as a means to identify relevant oncogenic pathways and potentially as a biomarker for identifying aggressive disease.
PROGRESSIVE EXERTIONAL DYSPNEA DUE TO ANOMALOUS ORIGIN OF THE RIGHT CORONARY ARTERY AND SUBAORTIC MEMBRANE IN A 68-YEAR-OLD MAN
Authors: Olushola O. Ogunleye, Oluwafemi Ajibola, Busala Oke, Mehmood Cheema, Jason Sperling
Journal: Journal of the American College of Cardiology (2022)
Anetumab ravtansine versus vinorelbine in patients with relapsed, mesothelin-positive malignant pleural mesothelioma (ARCS-M): a randomised, open-label phase 2 trial
Authors: Hedy L Kindler, Silvia Novello, Alessandra Bearz, Giovanni L Ceresoli, Joachim G J V Aerts, James Spicer, Paul Taylor, Kristiaan Nackaerts, Alastair Greystoke, Ross Jennens, Luana Calabrò, Jacobus A Burgers, Armando Santoro, Susana Cedrés, Piotr Serwatowski, Santiago Ponce, Jan P Van Meerbeeck, Anna K Nowak, George Blumenschein, Jonathan M Siegel, Linda Kasten, Karl Köchert, Annette O Walter, Barrett H Childs, Cem Elbi, Raffit Hassan, Dean A Fennell
Journal: The Lancet Oncology (2022)
Risk factors for infection and mortality caused by carbapenem-resistant Klebsiella pneumoniae: A large multicentre case–control and cohort study
Authors: Tao Lou, Xiaoxing Du, Ping Zhang, Qiucheng Shi, Xinhong Han, Peng Lan, Rushuang Yan, Huangdu Hu, Yanfei Wang, Xueqing Wu, Yan Jiang, Yunsong Yu
Journal: Journal of Infection (2022)
Hematopoietic stem cell transplantation for adolescents and adults with inborn errors of immunity: an EBMT IEWP study
Authors: Michael H. Albert, Tiarlan Sirait, Dirk-Jan Eikema, Katerina Bakunina, Claudia Wehr, Felipe Suarez, Maria Laura Fox, Nizar Mahlaoui, Andrew R. Gennery, Arjan C. Lankester, Rita Beier, Maria Ester Bernardo, Venetia Bigley, Caroline A. Lindemans, Siobhan O. Burns, Ben Carpenter, Jaroslaw Dybko, Tayfun Güngör, Fabian Hauck, Su Han Lum, Dmitry Balashov, Roland Meisel, Despina Moshous, Ansgar Schulz, Carsten Speckmann, Mary A. Slatter, Brigitte Strahm, Duygu Uckan-Cetinkaya, Isabelle Meyts, Tanja C. Vallée, Robert Wynn, Bénédicte Neven, Emma C. Morris, Alessandro Aiuti, Alexei Maschan, Mahmoud Aljurf, Tobias Gedde-Dahl, Gunhan Gurman, Victoria Bordon, Gergely Kriván, Franco Locatelli, Fulvio Porta, David Valcárcel, Yves Beguin, Maura Faraci, Nicolaus Kröger, Aleksandr Kulagin, Peter J. Shaw, Joan Hendrik Veelken, Cristina Diaz de Heredia, Franca Fagioli, Matthias Felber, Bernd Gruhn, Wolfgang Holter, Claudia Rössig, Petr Sedlacek, Jane Apperley, Mouhab Ayas, Ivana Bodova, Goda Choi, J.J. Cornelissen, Anne Sirvent, Anjum Khan, Alphan Kupesiz, Stig Lenhoff, Hakan Ozdogu, Nicolas von der Weid, Montserrat Rovira, Rik Schots, Donald C. Vinh
Journal: Blood (2022)
Operative Autonomy of Surgical Residents and Patient Outcomes
Authors: Andreas Rehm, Albert Ngu, Azeem Thahir
Journal: JAMA Surgery (2022)

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Safety and efficacy of three enteral feeding strategies in patients with severe stroke in China (OPENS): a multicentre, prospective, randomised, open-label, blinded-endpoint trial
Authors: Jingjing Zhao, Fang Yuan, Changgeng Song, Rong Yin, Mingze Chang, Wei Zhang, Bei Zhang, Liping Yu, Yi Jia, Yaling Ma, Yongbin Song, Chengkai Wang, Chaohui Song, Xinlai Wang, Lei Shang, Fang Yang, Wen Jiang, Wen Jiang, Fang Yang, Jingjing Zhao, Fang Yuan, Changgeng Song, Lili Sun, Yuanfang Zhao, Jiangya Wei, Lijuan Liu, Mengmeng Hu, Xuan Wang, Jingjing Zhang, Xiaodan Shi, Bo Hui, Rong Chen, Xianhui Ren, Fang Du, Rong Yin, Yaxuan Wei, Yuanming Li, Mingze Chang Chang, Xiujuan Zhang, Yanling Yin, Wei Zhang, Jun Guo, Peng Guo, Jiarui Lu, Chuan Li, Jinjin Shen, Miao Bai, Min Zhang, Bei Zhang, Shijun Zhang, Yulan Bai, Yanan Bai, Wenjun Fan, Lin Wang, Fangfang Yu, Yanni Ru, Wei Wei, Yaling Ma, Wenzong Wang, Ruoruo Hu, Yajuan Li, Xuemei Ma, Tao Lv, Liping Yu, Hao Zhu, Linsong Yang, Yaxin Wu, Junxia Cao, Yi Jia, Tao Wu, Hongxing Zhang, Saibing Liu, Bo Ning, Chaohui Song, Hongyan Zhao, Zhongyi Li, Haiyan Zhang, Mingming Wang, Yongbin Song, Yong Zhu, Chengkai Wang, Siwen Chen, Qianmeng Ren, Shuang Lu, Xinlai Wang, Qiufeng You, Zhiqin Liu, Yi Jiang, Jing Xiong, Xiaocheng Wang, Rong Zhao, Kang Huo, Chen Chen, Yongcai Qu, Li Ma, Xiai Yang, Yi Liu, Xingsheng Wang
Journal: The Lancet Neurology (2022)
Long-term Outcomes Among Patients With Advanced Kidney Disease Who Forgo Maintenance Dialysis
Authors: Susan P. Y. Wong, Tamara Rubenzik, Leila Zelnick, Sara N. Davison, Diana Louden, Taryn Oestreich, Ann L. Jennerich
Journal: JAMA Network Open (2022)

<h3>Importance</h3> An understanding of the long-term outcomes of patients with advanced chronic kidney disease not treated with maintenance dialysis is needed to improve shared decision-making and care practices for this population. <h3>Objective</h3> To evaluate survival, use of health care resources, changes in quality of life, and end-of-life care of patients with advanced kidney disease who forgo dialysis. <h3>Evidence Review</h3> MEDLINE, Embase (Excerpta Medica Database), and CINAHL (Cumulative Index of Nursing and Allied Health Literature) were searched from inception through December 3, 2021, for all English language longitudinal studies of adults in whom there was an explicit decision not to pursue maintenance dialysis. Two investigators independently reviewed all studies and selected those reporting survival, use of health care resources, changes in quality of life, or end-of-life care during follow-up. Studies of patients who initiated and then discontinued maintenance dialysis and patients in whom it was not clear that there was an explicit decision to forgo dialysis were excluded. One author abstracted all study data, of which 12% was independently adjudicated by a second author (&lt;1% error rate). <h3>Findings</h3> Forty-one cohort studies comprising 5102 patients (range, 11-812 patients) were included in this systematic review (5%-99% men; mean age range, 60-87 years). Substantial heterogeneity in study designs and measures used to report outcomes limited comparability across studies. Median survival of cohorts ranged from 1 to 41 months as measured from a baseline mean estimated glomerular filtration rate ranging from 7 to 19 mL/min/1.73 m<sup>2</sup>. Patients generally experienced 1 to 2 hospital admissions, 6 to 16 in-hospital days, 7 to 8 clinic visits, and 2 emergency department visits per person-year. During an observation period of 8 to 24 months, mental well-being improved, and physical well-being and overall quality of life were largely stable until late in the illness course. Among patients who died during follow-up, 20% to 76% had enrolled in hospice, 27% to 68% died in a hospital setting and 12% to 71% died at home; 57% to 76% were hospitalized, and 4% to 47% received an invasive procedure during the final month of life. <h3>Conclusions and Relevance</h3> Many patients who do not pursue dialysis survived several years and experienced sustained quality of life until late in the illness course. Nonetheless, use of acute care services was common and intensity of end-of-life care highly variable across cohorts. These findings suggest that consistent approaches to the study of conservative kidney management are needed to enhance the generalizability of findings and develop models of care that optimize outcomes among conservatively managed patients.
Development and External Validation of a Model to Predict Complex Treatment After Radiofrequency Ablation for Barrett’s Esophagus With Early Neoplasia
Authors: Sanne N. van Munster, Esther Nieuwenhuis, Raf Bisschops, Hilde Willekens, Bas L.A. M. Weusten, Lorenza Alvarez Herrero, Auke Bogte, Alaa Alkhalaf, Ed B.E. Schenk, Erik J. Schoon, Wouter Curvers, Arjun D. Koch, Pieter Jan F. de Jonge, Tjon J. Tang, Wouter B. Nagengast, Jessie Westerhof, Martin H.M. G. Houben, Jacques J.G. H.M. Bergman, Roos E. Pouw
Journal: Clinical Gastroenterology and Hepatology (2022)

Endoscopic eradication therapy for Barrett's esophagus (BE)-related neoplasia is safe and leads to complete eradication in the majority of patients. However, a subgroup will experience a more complex treatment course with a risk for failure or disease progression. Early identification of these patients may improve patient counseling and treatment outcomes. We aimed to develop a prognostic model for a complex treatment course.We collected data from a nationwide registry that captures outcomes for all patients undergoing endoscopic eradication therapy for early BE neoplasia. A complex treatment course was defined as neoplastic progression, treatment failure, or the need for endoscopic resection during the radiofrequency ablation treatment phase. We developed a prognostic model using logistic regression. We externally validated our model in an independent registry.A total of 1386 patients were included, of whom 78 (6%) had a complex treatment course. Our model identified patients with a BE length of 9 cm or longer with a visible lesion containing high-grade dysplasia/cancer, and patients with less than 50% squamous conversion after radiofrequency ablation were identified as high risk for a complex treatment. This applied to 8% of the study population and included 93% of all treatment failures and 76% of all patients with advanced neoplastic progression. The model appeared robust in multiple sensitivity analyses and performed well in external validation (area under the curve, 0.84).We developed a prognostic model that identified patients with a BE length of 9 cm or longer and high-grade dysplasia/esophageal adenocarcinoma and those with poor squamous regeneration as high risk for a complex treatment course. The good performance in external validation suggests that it may be used in clinical management (Netherlands Trial Register: NL7039).
SUSTAINED VENTRICULAR TACHYCARDIA AS AN INITIAL PRESENTATION OF COVID-19 RELATED PULMONARY EMBOLISM DESPITE PREVIOUS RIVAROXABAN THERAPY
Authors: Juan Alan Fuentes Mendoza, Jorge Antonio Cervantes Nieto, Jose Ramon Benitez, Israel Gallardo, Dulce Aguilera, Juan Fuentes Jaime
Journal: Journal of the American College of Cardiology (2022)
IMPACT OF SIGNIFICANT PREPROCEDURAL MITRAL REGURGITATION ON MORTALITY AFTER TRANSCATHETER AORTIC VALVE IMPLANTATION.
Authors: Maria Karmpalioti, Maria Drakopoulou, George Oikonomou, Chryssa Simopoulou, Stergios Soulaidopoulos, Anastasis Apostolos, Padelis Toskas, Konstantinos Stathogiannis, Andreas G. Synetos, George Latsios, Konstantinos Tsioufis, Konstantinos P. Toutouzas
Journal: Journal of the American College of Cardiology (2022)
FIRST-PHASE EJECTION FRACTION AND LONG-TERM SURVIVAL IN PATIENTS UNDERGOING TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: David Zahler, Omri Feder, Yishay Szekely, Yan Topilsky, Nir Flint, Maayan Konigstein, Amir Shlomo Halkin, Samuel Bazan, Yaron Arbel, Ariel Finkelstein, Shmuel Banai, Jeremy Ben-Shoshan
Journal: Journal of the American College of Cardiology (2022)
AWARENESS REGARDING CARDIOVASCULAR DISEASE AMONG SCHOOL-GOING ADOLESCENTS IN A RURAL AREA OF BANGALORE, INDIA
Authors: Vivek Bhat, Reubel Coates, Natasha Pillai, Neha Zacharias, Reema D’Souza, Geo Judes Matthews, Deepthi Shanbhag
Journal: Journal of the American College of Cardiology (2022)
Abstract P3-01-09: Mri in the pre-operative workup of breast cancer patients
Authors: Solange Bayard, Genevieve Fasano, Yalei Chen, Jennifer Marti, Rache Simmons, Alexander Swistel, Michelle Drotman, Melissa Davis, Lisa Newman
Journal: Cancer Research (2022)

Abstract PurposeThe utility of pre-operative MRI (preop MRI) for patients with a new breast cancer diagnosis is controversial. Recently there has been increased use of routine MRI during preoperative workup to evaluate for areas necessitating additional biopsy and planning of operative resection extent; however, these practices carry the risk of delaying treatment, and subjecting patients to unnecessary biopsies and overly extensive resections. Triple negative breast cancer (TNBC) is more difficult to detect on mammography compared to non-TNBC, and patients with TNBC do not receive the chemoprevention benefits of adjuvant endocrine therapy; preop breast MRI to detect mammographically occult foci of disease may therefore be more relevant for patients with TNBC. MethodsOutcomes were evaluated for TNBC patients treated in the prospectively-maintained database of an academic cancer program in a metropolitan city of the Northeast, 1998-2018. ResultsOf 428 TNBC cases, 35.7% (153) had pre-op MRI. 43.6% (61) of 140 TNBC cases ≤50 years old had pre-op MRI compared to 31.9% of 288 TNBC cases &amp;gt;50 years old (p=0.016). There were no differences in race, or stage at presentation between those who had pre-op MRI and those who did not. 34% (52) of pre-op MRI TNBC cases underwent additional biopsies versus 0.43% (1) of TNBC patients who did not have pre-op MRI (p&amp;lt;0.0001). Average time to treatment was 29.5 days for pre-op MRI TNBC cases compared to 25 days for TNBC patients who did not have pre-op MRI (p=0.0026). 9.8% (15) of pre-op MRI TNBC cases underwent re-excisions versus 17.7% (41) of TNBC patients who did not have pre-op MRI (p=0.076). Of those who had mastectomies, patients who had pre-op MRI were more likely to have bilateral mastectomies (21.6% (33) pre-op MRI TNBC v 12.9% (30) of TNBC patients who did not have pre-op MRI (p=0.0471)). Five-year overall survival was no different between patients who had pre-op MRI and those who did not (95.2% vs 95.3% respectively; p=0.79). Among patients undergoing breast conserving surgery, there were no significant differences in the rates of local recurrence between patients that had preop MRI compared to those that did not (13.1% vs 9.1% p=0.392). ConclusionOur data demonstrated that preop MRI in TNBC patients was associated with additional biopsies, more extensive breast surgery, and longer time to treatment. Preop MRI had no impact on survival or local recurrence among patients undergoing breast conserving surgery. Citation Format: Solange Bayard, Genevieve Fasano, Yalei Chen, Jennifer Marti, Rache Simmons, Alexander Swistel, Michelle Drotman, Melissa Davis, Lisa Newman. Mri in the pre-operative workup of breast cancer patients [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P3-01-09.
Comparison of ultrasound attenuation by calcium pyrophosphate, hydroxyapatite and monosodium urate crystals: a proof-of-concept study
Authors: Georgios Filippou, Giovanni Pacini, Silvia Sirotti, Matthias Zadory, Davide Carboni, Arianna Damiani, Elisa Fiorentini, Edoardo Cipolletta, Emilio Filippucci, Johannes M Froehlich, Piercarlo Sarzi Puttini, Fabio Becce
Journal: Annals of the Rheumatic Diseases (2022)
CLO22-043: Humoral Immune Response Following COVID-19 Vaccination in Patients With Chronic Lymphocytic Leukemia and Other Indolent Lymphomas: A Large, Single-Center Observational Study
Authors: Peter G Doukas, Frederique St Pierre, Jennifer Boyer, Mariana Nieves, Shuo Ma
Journal: Journal of the National Comprehensive Cancer Network (2022)

"CLO22-043: Humoral Immune Response Following COVID-19 Vaccination in Patients With Chronic Lymphocytic Leukemia and Other Indolent Lymphomas: A Large, Single-Center Observational Study" published on 31 Mar 2022 by National Comprehensive Cancer Network.