tbuckley/cabot-search huggingface dataset:
Team Sport Risk Exposure Framework-2 (TS-REF-2) to identify sports activities and contacts at increased SARS-CoV-2 transmission risk during the COVID-19 pandemic
Authors: Ben Jones, Gemma Phillips, Clive Beggs, James Calder, Matthew Cross, Neil Pearce, Clint Readhead, Jenifer Smith, Keith A Stokes, Simon Kemp
Journal: British Journal of Sports Medicine (2021)

The Team Sports Risk Exposure Framework (TS-REF) was developed in July 2020 by experts in sports medicine, virology, sports science and public health to facilitate the safe return of sport during the COVID-19 pandemic.1 The TS-REF was developed at the time when the outdoor transmission risk of SARS-CoV-2 during sport was unknown. The TS-REF has been adopted by Public Health England and the UK Government (Department for Digital, Culture, Media and Sport), for use within both elite and community sports,2 to both determine the risk of SARS-CoV-2 transmission during specific sporting activities (eg, rugby tackle),1 and to identify and isolate increased risk contacts during sport.3 The TS-REF classified increased risk contacts as player-to-player interactions ‘ within 1 m, directly face to face, for 3 or more seconds’.1 

Increased risk contacts as defined in the TS-REF were studied in rugby league, following interactions with eight infectious players across four matches.3 Increased risk contacts were monitored for 14-days during their isolation period and serially tested for SARS-CoV-2. Of the 28 identified increased risk contacts from the matches, only one player subsequently tested positive for SARS-CoV-2, which was linked to an internal club outbreak and believed unrelated to training activities. Another study in professional soccer observed similar findings,4 collectively suggesting the risk of outdoor transmission during sports appears lower than first thought.3 4 Consequently, the TS-REF may require players to unnecessarily isolate who are not at an increased risk of infection. Our aim was to update the TS-REF based on our evolving understanding of SARS-CoV-2 transmission during sports.

SARS-CoV-2 can be transmitted by both exhaled large ‘ballistic’ respiratory (>100 …
慢性完全閉塞疾患に対する薬剤溶出ステントを用いた「Full Metal Jacket」(ステント長≧50mm)の成績
Authors: Mouri Shinsuke, Muramatsu Toshiya, Tsukahara Reiko, Itoh Yoshiaki, Sakai Tsuyoshi, Ishimori Hiroshi, Hirano Keisuke, Nakano Masatsugu, Yamawaki Masahiro, Araki Motoharu, Katoh Tamon, Kobayashi Norihiro, Takimura Hideyuki, Sakamoto Yasunari, Tsutsumi Masakazu, Takama Takurou, Takafuji Hiroya, Tokuda Takahiro, Makino Kenji
Journal: Circulation (2014)
Smooth Muscle Overexpression of PGC1α Attenuates Atherosclerosis in Rabbits
Authors: Zhe Wei, Hoshun Chong, Qixia Jiang, Yuhang Tang, Jinhong Xu, Haoquan Wang, Yanteng Shi, Le Cui, Jing Li, Yujing Zhang, Yunxing Xue, Jutang Li, George Liu, Xi Chen, Dongjin Wang, Chen-Yu Zhang, Xiaohong Jiang
Journal: Circulation Research (2021)

Rationale: Targeting vascular smooth muscle cell (VSMC) phenotypic switching is a promising therapeutic approach for atherosclerosis. Dysregulation of PGC1α (peroxisome proliferator-activated receptor gamma, coactivator 1α), a key regulator of cellular energy metabolism, has been implicated in the pathogenesis of atherosclerosis, yet its role in atherosclerosis remains controversial. Objective: The current study aimed to determine whether and how PGC1α in VSMCs regulates atherosclerosis progression. Methods and Results: We generated transgenic rabbits with SMC-specific PGC1α overexpression and showed that these rabbits developed significantly less aortic atherosclerosis than their nontransgenic littermates after high-cholesterol diet feeding, while total plasma cholesterol levels were similar. As indicated by the restored expression of VSMC differentiation marker genes, the high-cholesterol diet-induced phenotypic switching in the aortic media was largely reversed in transgenic rabbits, accompanied by decreased levels of synthetic phenotype genes, proinflammatory cytokines, adhesion molecules, macrophage infiltration, MMPs (matrix metalloproteinases), reactive oxygen species production and senescence. Ex vivo studies further showed that VSMC-specific PGC1α overexpression markedly suppressed the promotive effect of high-cholesterol diet feeding on the association of SRF (serum response factor) with ELK1 (ETS transcription factor ELK1), a TCF (ternary complex factor) that acts as a myogenic repressor in VSMCs, thereby preserving the VSMC contractile phenotype. Furthermore, knockdown of PGC1α remarkably increased ERK (extracellular signal-regulated kinase)1/2-ELK-1 signaling, which promoted phenotypic switching and proliferation of cultured rabbit VSMCs. In addition, we showed that PGC1α can regulate EGFR (epidermal growth factor receptor)-ERK1/2 MAPK (mitogen-activated protein kinase) signaling via modulating PPARγ (peroxisome proliferator-activated receptor γ) activity in RVSMCs (rabbit vascular smooth muscle cells). Finally, we showed that these beneficial results of SMC-specific PGC1α overexpression can be extrapolated from rabbits to human VSMCs and clinical settings. Conclusions: We demonstrated a critical role of PGC1α in maintaining the contractile phenotype of VSMCs and highlighted the therapeutic potential of PGC1α for atherosclerosis.
RIG1 inhibits the Ras/mitogen activated protein kinase pathway by suppression the activation of Ras
Authors: Shun-Yuan Jiang, Fu-Ming Tsai, Rong-Yaun Shyu
Journal: Cancer Research (2005)

996  The RIG1 (Retinoid-Inducible gene I) protein is a retinoid-inducible growth regulator. Previous studies have shown that the RIG1 protein inhibits signal pathways of Ras/mitogen activated protein kinases, but neither the mode of action nor the site of inhibition of RIG1 is known. We therefore investigated the effects of RIG1 on activation of Ras proteins in HtTA cervical cancer cells. RIG1 inhibited levels of activated Ras (Ras-GTP) in cells transfected with mutated H-, N-, and K-RasG12V or the wild type H- and N-Ras, which had been stimulated by epidermal growth factor. RIG1 protein co-localized and immunoprecipitated with the Ras protein. The carboxyl terminal truncated RIG1 (RIG1ΔC) failed to suppress Ras activation. However, both RIG1 and RIG1ΔC suppressed ELK transactivation by more than 98% in H-RasG12V transfected cells. Neither RIG1 nor RIG1ΔC had an inhibitory effect on phosphorylation of extracellular-signal regulated kinases1/2 in cells transfected with the constitutively active mutant of Raf. Results of this study indicate that RIG1 exertes its inhibitory effect at the level of Ras activation, which is Ras subtype-independent and is dependent on membrane localization of the RIG1 protein.
Acute Coronary Syndrome With ST-Segment Elevation in Inferior Leads
Authors: Anish Kapil, Abhishek Thakur, Satyavir Yadav
Journal: JAMA Internal Medicine (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Zenker's peroral endoscopic myotomy (Z-POEM) for recurrent Zenker diverticulum: not so fast!
Authors: Sauid Ishaq, Keith Siau, Toshio Kuwai, Chris J. Mulder, Helmut Neumann
Journal: Endoscopy (2021)

See also:Impact of prior treatment on feasibility and outcomes of Zenker’s peroral endoscopic myotomy (Z-POEM) Endoscopy 2021; 53(07): 722-726DOI: 10.1055/a-1276-0219See also:Reply to Ishaq et al.Endoscopy 2021; 53(07): 768-768DOI: 10.1055/a-1348-1012
Transdermal Drug Delivery: Zn‐MOF Encapsulated Antibacterial and Degradable Microneedles Array for Promoting Wound Healing (Adv. Healthcare Mater. 12/2021)
Authors: Shun Yao, Junjie Chi, Yuetong Wang, Yuanjin Zhao, Yuan Luo, Yongan Wang
Journal: Advanced Healthcare Materials (2021)

In article number 2100056 by Yongan Wang, Yuan Luo, Yuanjin Zhao, and co-workers, a ZIF-8@MeHA microneedle (MN) array is fabricated by template molding method for wound healing. Such an MN patch has a good antibacterial effect by releasing Zn2+ to kill microbes. Meanwhile, the MeHA hydrogel is capable of promoting the regeneration of neonatal epithelial tissues through gradual degradation.
Foot orthoses and physiotherapy in the treatment of patellofemoral pain syndrome: randomised clinical trial (Reprinted from BMJ, vol 337, pg a1735, 2008)
Authors: Natalie Collins, Kay Crossley, Elaine Beller, Ross Darnell, Thomas McPoil, Bill Vicenzino
Journal: British Journal of Sports Medicine (2009)

Objective To compare the clinical efficacy of foot orthoses in the management of patellofemoral pain syndrome with flat inserts or physiotherapy, and to investigate the effectiveness of foot orthoses plus physiotherapy.
Abstract 390: Dysregulation of ATF2 in Dilated Cardiomyopathy Caused by FBXO32 Mutation
Authors: Nadya Alyacoub, Salma Awad, Mohmad Kunhi, Walid Al-Habeeb, Coralie Poizat
Journal: Circulation Research (2016)

Background: Dilated cardiomyopathy (DCM) is a common form of cardiomyopathy causing systolic dysfunction and heart failure. Rare variants in more than 30 genes mostly encoding sarcomeric proteins and proteins of the extracellular matrix have been implicated in familial DCM to date. We recently identified a novel mutation (Gly243Arg) in FBXO32 causing familial DCM through abnormal SKP1/CUL/F-BOX (SCF) complex formation and defects in proteins regulating the autophagy/lysosome machinery (Al-Yacoub, Genome Biology, 2016). Objective: To explore in more details the mechanisms by which the defective SCF FBXO32 complex leads to the development of DCM. Methodology: Using a PCR-based microarray, we screened for mRNAs significantly dysregulated in the heart of the patient carrying the FBXO32 mutation compared to control and idiopathic human hearts. Subsequently, we validated dysregulation of a candidate gene using immunoblot analysis and tested the effect of the mutant or wild-type FBXO32 on the novel candidate identified in primary neonatal rat cardiomyocytes. Results: We found a robust up-regulation in mRNA expression of the Activating transcription Factor 2 (ATF2), a member of the leucine zipper family of DNA binding proteins, which plays a critical role in cardiac development. ATF2 protein level was also strongly increased in the heart with the FBXO32 mutation compared to control hearts and to hearts of idiopathic origin. Expression of the mutant FBXO32 protein in primary cardiomyocytes enhanced ATF2 protein expression compared to cells expressing the wild-type FBXO32 protein. Since FBXO32 is member of the SCF complex and has ubiquitin ligase activity, experiments are now investigating whether FBXO32 directly regulates ATF2 protein stability and the role of ATF2 in autophagy flux regulation in dilated cardiomyopathy. Conclusion: Our results indicate that abnormal SCF activity due to the FBXO32 mutation stabilizes the AFT2 transcription factor and suggest a new mechanism by aberrant SCF activity causes DCM in human.
MR1‐dependent immune surveillance of the skin contributes to pathogenesis and is a photobiological target of UV light therapy in a mouse model of atopic dermatitis
Authors: Karmella Naidoo, Katherine Woods, Christophe Pellefigues, Alissa Cait, David O'Sullivan, Katie Gell, Andrew J. Marshall, Regan J. Anderson, Yanyan Li, Alfonso Schmidt, Kef Prasit, Johannes U. Mayer, Aurelie Gestin, Ian F. Hermans, Gavin Painter, Elizabeth A. Jacobsen, Olivier Gasser
Journal: Allergy (2021)

Mucosal-associated invariant T (MAIT) cells are unconventional T cells which recognize microbial metabolites presented by the major histocompatibility complex class I-related molecule MR1. Although MAIT cells have been shown to reside in human and murine skin, their contribution to atopic dermatitis (AD), an inflammatory skin disease associated with barrier dysfunction and microbial translocation, has not yet been determined.Genetic deletion of MR1 and topical treatment with inhibitory MR1 ligands, which result in the absence and functional inhibition of MAIT cells, respectively, were used to investigate the role of MR1-dependent immune surveillance in a MC903-driven murine model of AD.The absence or inhibition of MR1 arrested AD disease progression through the blockade of both eosinophil activation and recruitment of IL-4- and IL-13-producing cells. In addition, the therapeutic efficacy of phototherapy against MC903-driven AD could be increased with prior application of folate, which photodegrades into the inhibitory MR1 ligand 6-formylpterin.We identified MAIT cells as sentinels and mediators of cutaneous type 2 immunity. Their pathogenic activity can be inhibited by topical application or endogenous generation, via phototherapy, of inhibitory MR1 ligands.
Sirolimus-Eluting Stent vs Paclitaxel-Eluting Stent for Coronary Intervention in Patients with Renal Failure on Hemodialysis
Authors: Tsujita Hiroaki, Hamazaki Yuji, Kondo Seita, Hosokawa Satoshi, Tsukamoto Shigeto, Mutoh Mitsunori, Sakurai Masayuki, Nishimura Hideki, Kobayashi Youichi
Journal: Circulation (2011)
Congenital infection of SARS-CoV-2 in live-born neonates: a population-based descriptive study
Authors: Itziar Garcia-Ruiz, Elena Sulleiro, Berta Serrano, Irene Fernandez-Buhigas, Leire Rodriguez-Gomez, David Sanchez-Nieves Fernandez, Andrés Anton-Pagarolas, Juliana Esperalba-Esquerra, Marie Antoinette Frick, Fatima Camba, Alexandra Navarro-Jimenez, Nuria Fernandez-Hidalgo, Nerea Maiz, Elena Carreras, Anna Suy, Jorge Burgos, Vicente Diago, María de la Calle, Marta Muner, Sara Ruiz, Daniel Orós, Olga Ocón, Francisca Sonia Molina García, Mar Gil, Juan Luis Delgado
Journal: Clinical Microbiology and Infection (2021)
Abstract 465: PERC: A 23 Years Experience of Disseminating BLS Techniques in Underserved Areas
Authors: Neiberg A Lima, Swelen Lima, Gabriel Pessoa, Priscila Costa, Thomaz Costa, Emanuel Vasconcelos, Wesla Praxedes, Larissa Silva, Thais Silva, Thais Barbosa
Journal: Circulation (2019)

Background: Ischemic heart disease is the main cause of mortality in Brazil. Sudden cardiac death is often the initial presentation of a myocardial infarction, however Basic Life Support (BLS) undertraining is real not only for lay rescuers but for health care providers in Brazil. A group of medical students from the Universidade Federal do Ceara (UFC) founded in 1996 the Cardiorespiratory Resuscitation Education Program (PERC) with a goal of disseminating BLS techniques. Objective: Emphasize the importance of creating social projects to propagate BLS techniques in underserved populations. Methods: An experience of over 23 years of BLS training with a non profit medical student group in the northeast of Brazil will be reported. Results/Discussion: The group is formed by students from the first to the last year of the UFC medical school. They are trained by cardiology faculties and senior members on the most recent ILCOR guidelines for BLS. A member usually stays in the program for two or three years and during this time is responsible to facilitate free classes in schools, public hospitals, health centers and medical schools. These courses are based on one lecture followed by a hands on training on CPR manikins. Pre and post testing are applied to evaluate satisfaction and learning. With 23 years of experience, a total of 11,841 people were directly trained by our program: 4.626 lay rescuers, 3.124 medical/nursing students and 4.091 health providers. A satisfaction rate is above 95%. The impact of this program in our community is immeasurable. Conclusion: Even though these courses don’t replace the official AHA-BLS training, nonprofit organizations as PERC can play an important role in communities with limited resources, helping to disseminate BLS techniques and maybe decreasing the mortality and morbidity associated with the sudden cardiac death in those areas.
Risk factors for post-COVID-19 condition in previously hospitalised children using the ISARIC Global follow-up protocol: a prospective cohort study
Authors: Ismail M. Osmanov, Ekaterina Spiridonova, Polina Bobkova, Aysylu Gamirova, Anastasia Shikhaleva, Margarita Andreeva, Oleg Blyuss, Yasmin El-Taravi, Audrey DunnGalvin, Pasquale Comberiati, Diego G. Peroni, Christian Apfelbacher, Jon Genuneit, Lyudmila Mazankova, Alexandra Miroshina, Evgeniya Chistyakova, Elmira Samitova, Svetlana Borzakova, Elena Bondarenko, Anatoliy A. Korsunskiy, Irina Konova, Sarah Wulf Hanson, Gail Carson, Louise Sigfrid, Janet T. Scott, Matthew Greenhawt, Elizabeth A. Whittaker, Elena Garralda, Olivia V. Swann, Danilo Buonsenso, Dasha E. Nicholls, Frances Simpson, Christina Jones, Malcolm G. Semple, John O. Warner, Theo Vos, Piero Olliaro, Daniel Munblit
Journal: European Respiratory Journal (2021)

The long-term sequelae of coronavirus disease 2019 (COVID-19) in children remain poorly characterised. This study aimed to assess long-term outcomes in children previously hospitalised with COVID-19 and associated risk factors.This is a prospective cohort study of children (≤18 years old) admitted to hospital with confirmed COVID-19. Children admitted between 2 April 2020 and 26 August 2020 were included. Telephone interviews used the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 Health and Wellbeing Follow-up Survey for Children. Persistent symptoms (>5 months) were further categorised by system(s) involved.518 out of 853 (61%) eligible children were available for the follow-up assessment and included in the study. Median (interquartile range (IQR)) age was 10.4 (3-15.2) years and 270 (52.1%) were girls. Median (IQR) follow-up since hospital discharge was 256 (223-271) days. At the time of the follow-up interview 126 (24.3%) participants reported persistent symptoms, among which fatigue (53, 10.7%), sleep disturbance (36, 6.9%) and sensory problems (29, 5.6%) were the most common. Multiple symptoms were experienced by 44 (8.4%) participants. Risk factors for persistent symptoms were: older age "6-11 years" (OR 2.74, 95% CI 1.37-5.75) and "12-18 years" (OR 2.68, 95% CI 1.41-5.4), and a history of allergic diseases (OR 1.67, 95% CI 1.04-2.67).A quarter of children experienced persistent symptoms months after hospitalisation with acute COVID-19 infection, with almost one in 10 experiencing multisystem involvement. Older age and allergic diseases were associated with higher risk of persistent symptoms at follow-up.
Clinical Outcomes of Microtransplantation for Older Adults with Acute Myeloid Leukemia
Authors: Anthony D. Sung, Carlos M. de Castro, Thomas W. LeBlanc, Gwynn D. Long, Donna B. Adams, Danielle M. Brander, Sandeep Dave, Louis F. Diehl, Phuong Linh Doan, Therese Hennig, Yubin Kang, Matthew S. McKinney, Lindsay A.M Rein, Dorothy A. Sipkins, Yiping Yang, Nelson J. Chao, David A. Rizzieri
Journal: Blood (2017)
The Evidence Behind Robot-Assisted Abdominopelvic Surgery
Authors: Naila H. Dhanani, Oscar A. Olavarria, Karla Bernardi, Nicole B. Lyons, Julie L. Holihan, Michele Loor, Alex B. Haynes, Mike K. Liang
Journal: Annals of Internal Medicine (2021)

Use of robot-assisted surgery has increased dramatically since its advent in the 1980s, and nearly all surgical subspecialties have adopted it. However, whether it has advantages compared with laparoscopy or open surgery is unknown.To assess the quality of evidence and outcomes of robot-assisted surgery compared with laparoscopy and open surgery in adults.PubMed, EMBASE, Scopus, and the Cochrane Central Register of Controlled Trials were searched from inception to April 2021.Randomized controlled trials that compared robot-assisted abdominopelvic surgery with laparoscopy, open surgery, or both.Two reviewers independently extracted study data and risk of bias.A total of 50 studies with 4898 patients were included. Of the 39 studies that reported incidence of Clavien-Dindo complications, 4 (10%) showed fewer complications with robot-assisted surgery. The majority of studies showed no difference in intraoperative complications, conversion rates, and long-term outcomes. Overall, robot-assisted surgery had longer operative duration than laparoscopy, but no obvious difference was seen versus open surgery.Heterogeneity was present among and within the included surgical subspecialties, which precluded meta-analysis. Several trials may not have been powered to assess relevant differences in outcomes.There is currently no clear advantage with existing robotic platforms, which are costly and increase operative duration. With refinement, competition, and cost reduction, future versions have the potential to improve clinical outcomes without the existing disadvantages.None. (PROSPERO: CRD42020182027).