POS1004 BOTH SPONDYLOARTHRITIS AND PSORIATIC ARTHRITIS PATIENTS HAVE STRONG FAMILY HISTORIES
Authors: G. K. Yardimci, B. Farisoğullari, E. C. Bolek, E. Bilgin, E. Duran, G. Ayan, Z. Özsoy, G. Sandal Uzun, L. Kiliç, A. Akdoğan, O. Karadag, Ş. A. Bilgen, A. İ. Ertenli, U. Kalyoncu, S. Kiraz
Journal: Annals of the Rheumatic Diseases (2021)

Background: Family history is one of the hallmarks of spondyloarthritis (SpA) and psoriatic arthritis (PsA) [1, 2]. Some patients have a strong family history that more than 2 relatives have spondyloarthritis related diseases. The effects of strong family history on SpA features were not known very well. Objectives: The aim of this study is to evaluate the effects of family history in SpA and PsA patients. Methods: HUR-BIO (Hacettepe University Biologic Registry) is a prospective, single center database of biological treatments since 2005, and to date 3071 SpA and 526 PsA patients have been recorded. Demographic, clinical characteristics, disease activity parameters, a detailed family history of SpA and SpA features (presence of SpA including PsA, psoriasis, inflammatory bowel disease and uveitis) and laboratory data before anti-TNF treatments of the patients were noted. Results: 2807 SpA (53.6% male) and 506 PsA (31.4% male) patients’ family history were available and analysed. A positive family history was noted in 27.6% of the SpA and 31.0% of the PsA patients (ns). 7.4% of the SpA patients and 8.9% of the PsA patients had family history in more than one relative (Table 1). In SpA patients with a family history, uveitis was more frequent than patients without (14.4% vs 10.6%, p=0.006). Except for a higher male predominance and uveitis (53% vs 32% p=0.006 and 9% vs 2% p=0.003 respectively) in patients with ≥2 relatives with SpA features, there were no differences in PsA patients regarding family history. The presence of family history and HLA-B27 (63.7% vs 37.6%, p&lt;0.001) positivity were associated in SpA patients but not in PsA patients (31.2% vs 20.0, p=0.13). Conclusion: Family history was present in about one third of the patients of PsA and SpA. It is not uncommon for two or more family members to have a SpA feature. Presence of family history may be associated with some clinical conditions, such as uveitis. References: [1]Solmaz, D., et al., Impact of Having Family History of Psoriasis or Psoriatic Arthritis on Psoriatic Disease. Arthritis Care Res (Hoboken), 2020. 72 (1): p. 63-68. [2]Zurita Prada, P.A., et al., Influence of smoking and obesity on treatment response in patients with axial spondyloarthritis: a systematic literature review. Clin Rheumatol, 2020. Table 1. Family history in PsA and SpA patients PsA (n=506 ) SpA (n=2807 ) ≥ 1 family history, n (% ) 157 (31.0) 774 (27.6) ≥1 first-degree relative, n (% ) 114 (22.5) 489 (17.4) ≥2 first-degree relatives, n (% ) 21 (4.2) 77 (2.7) ≥2 relatives (both first- and second-degree), n (% ) 45 (8.9) 208 (7.4) Family history •Psoriasis, n (% ) 120 (23.7) 155 (5.5) •Psoriatic arthritis, n (% ) 14 (2.8) 9 (0.3) •Spondyloarthritis, n (% ) 38 (7.5) 643 (22.9) •Inflammatory bowel disease, n (% ) 1 (0.2) 10 (0.4) •Uveitis, n (% ) 0 2 (0.1) Disclosure of Interests: None declared.