tbuckley/cabot-search huggingface dataset:
Maturation Block in Childhood Cancer
Authors: Sam Behjati, Richard J. Gilbertson, Stefan M. Pfister
Journal: Cancer Discovery (2021)

The key differences between tumors arising in children and those in adults stem from the cellular origin of cancer at different ages, with adult cancers arising within aging cell hierarchies, as a consequence of accumulated damage and mutagenesis, in contrast to childhood tumors that are born in aberrantly developing tissues. A distinct biological property of childhood tumor cells-a block of developmental maturation-may hold the key to advancing the treatment of childhood cancer beyond cytotoxic strategies.
The influence of hypercholesterolemia on the occurrence of myocardial infarction in 47,294 Japanese hypercholesterolemic population with no prior coronary artery disease: Primary prevention in the J-LIT study Masunori Matsuzaki, Toru Kita, Hiroshi Mabuchi, Yuji Matsuzawa, Noriaki Nakaya, Shinichi Oikawa, Yasushi Saito, Jun Sasaki, Kazuaki Shimamoto, Hiroshige Itakura, The J-LIT Study Group. Yamaguchi University, Yamaguchi, Japan
Journal: Journal of the American College of Cardiology (2001)
Lewy bodies
Authors: S Curran, M Wrigley
Journal: American Journal of Psychiatry (1997)

The research article by Dr. Simon Wessely and colleagues (1) links chronic fatigue syndrome with psychiatric morbidity and concludes that chronic fatigue syndrome might not constitute "a specific nosological entity."Upon reflection, however, this research elucidates the shortcomings of the 1994 Centers for Disease Control (CDC) case definition (2).Wessely et al. used this definition and found that subjects with chronic fatigue syndrome and subjects with idiopathic chronic fatigue scored significantly higher on measures of depression and anxiety and tended to report symptoms more often than subjects not suffering from chronic fatigue.Such findings also resulted when other case definitions were applied (3-5).These results are not surprising, in light of the composition of the 1994 CDC case definition, which, like the others, inherently increases the likelihood that individuals with psychiatric morbidity will be selected as patients who suffer from chronic fatigue syndrome.This is due to considerable overlap between the symptom criteria for chronic fatigue syndrome and the symptoms listed for the DSM-IV classifications of major depressive episode and generalized anxiety disorder.Such overlap, in our view, would account for the findings by Wessely et al. with regard to depression, anxiety, and psychiatric morbidity.There is a large body of evidence that links the tendency to report symptoms with psychiatric morbidity (6).The process of selecting a cohort on the basis of self-reported subjective symptoms and then concluding that this cohort is characterized by psychiatric morbidity only begs the question of whether chronic fatigue syndrome constitutes a distinct disease entity.While Wessely et al.'s findings suggest that symptoms such as postexertional malaise, muscle weakness, and myalgia might have some discriminative potential in the diagnosis of chronic fatigue syndrome, these findings could also reflect a general tendency to report symptoms.As Wessely et al. so appropriately stated in their conclusions, "The stated desire of all of the current chronic fatigue syndrome case definitions is to attempt to isolate a pure syndrome distinct from other medical or psychiatric categories."Clearly, the 1994 CDC case definition fails to do this adequately.We hope that further research and discussion will follow to improve upon the case definition so that it identifies and isolates a distinct clinical entity that does not incorporate the term "chronic fatigue" within its name.However, the continued reliance upon self-reported subjective symptoms, especially those that are used in the diagnosis of psychiatric disorders, will only serve to inadvertently select individuals who suffer from psychiatric conditions and exclude true cases of chronic fatigue syndrome in future research.
New look at the National Health Service.
Journal: BMJ (1967)

activity.The patient usually complains of pain in the hip or knee for a week or ten days, and he may have a limp.The physical signs may be slight at first-there may be no more than a few degrees of limitation of movement of the hip, with some pain at the extremes of movement.More rarely displacement of a complete fracture will occur, and the patient will collapse, unable to walk.The earliest radiographic change is the appearance of a faint haze of endosteal callus within the neck of the femur.Though this can usually be seen in retrospect, it may be missed at first, and a definite crack is likely to develop in the cortex.If there is no fracture line on x-ray treatment may be limited to bed rest followed by protection from weight-bearing until the pain has gone.When a crack can be identified it is better to use internal fixation, and, as it is difficult to insert a trifin nail into hard young bone, thin pins of the Moore or Newman type should be used.
Practical Observations on certain Diseases of the Chest, and on the Principles of Auscultation
Journal: BMJ (1849)

Had Dr Blakiston's volume been of a less solid character than it is, and less fitted to outlive the hour of its appearance, we should have regretted the length of time it has remained unnoticed m this journal; as it is, our continued silence (the result of accident, not of choice) can do the author no mischief, and therefore, on his account, gives us no pain.That we have formed a high estimate of his labours, may be gathered from this statement; but the higher that estimate, the more disposed, we fear, we shall be to criticise (perhaps, he will say, to carp at) certain views and doctrines which appear to us not altogether accordant with sound experience; the errors of A. B. may be allowed to circulate with impunity ; the presumed * Bouillaud and other French writers, who exhibit perpetual inacquaintance with the true positions of the inner edges of the lungs, have given currency to this imaginary description of natural dullness in the cardiac region.
Enzyme activity may hold key to cataract prevention
Authors: H. Cole
Journal: JAMA (1985)

"The principal and perhaps only disease of the human lens is the opacification of the lens—a cataract. However, approximately 60% of persons between the ages of 65 and 74 [years] in the United States show some signs of cataract development, and cataracts are the leading cause of blindness in Africa," reported William Rathbun, PhD, associate professor, Department of Ophthalmology, University of Minnesota Medical School, Minneapolis, in discussing "The Achilles Heel of the Human Lens" at the Research to Prevent Blindness seminar in Washington, DC. Cataracts may be unavoidable. Ultraviolet light, present in sunlight and many forms of artificial light—when incident on the lens—produces free radicals and oxidation products such as hydrogen peroxide, that lead to the development of cataracts. An apparent defense mechanism in the young, healthy lens is a tripeptide—glutathione. Work in Rathbun's laboratory has demonstrated that the glutathione content of the lens decreases with age. That "concentration has
Engineered Bacteria Enhance Immunotherapy and Targeted Therapy through Stromal Remodeling of Tumors (Adv. Healthcare Mater. 2/2022)
Authors: Shindu C. Thomas, Tushar Madaan, Nitin S. Kamble, Nabil A. Siddiqui, Giovanni M. Pauletti, Nalinikanth Kotagiri
Journal: Advanced Healthcare Materials (2022)

Targeted Therapy In article number 2101487 by Nalinikanth Kotagiri and co-workers, engineered hypervesiculating Escherichia coli Nissle capable of localizing in tumors is utilized to deliver the cytolysin A (ClyA)-hyaluronidase (Hy) fusion protein by outer membrane vesicles to modulate the tumor matrix. Recombinant Hy decreases tumor tissue hyaluronic acid thereby improving the penetrability of anticancer agents and potentiation of their effect in mouse models of breast and colon cancer.
Correction to: Deep Vein Thrombosis in Hospitalized Patients With COVID-19 in Wuhan, China: Prevalence, Risk Factors, and Outcome
Journal: Circulation (2020)

it has come to the authors' attention that several corrections are needed:1.The sentence "There was no statistically significant difference between the DVT and non-DVT groups (22 [33.3%] vs 31[40.3%];P = 0.393)."should be changed to "There was no statistically significant difference of DVT prophylaxis between the DVT and non-DVT groups (22 [33.3%] versus 31 [40.3%];P=0.393)." 2. The sentence "and more patients with DVT had a higher right ventricular myocardial performance index (0.45 ± 0.10 vs 0.38 ± 0.13; P = 0.011)" should be changed to "and patients with DVT had a higher right ventricular myocardial performance index than patients without DVT (0.45±0.10 versus 0.38±0.13;P=0.011)." 3. The sentence "Patients with DVT had a worse prognosis than patients without DVT, including more admissions to the ICU (12 [18.2] vs 3 [3.9];P = 0.005), fewer discharges (32 [48.5] vs 60 [77.9];P < 0.001), and more deaths (23 [34.8] vs 9 [11.7];P = 0.001)."should be changed to "Patients with DVT had a worse prognosis than patients without DVT, including more admissions to the ICU (12 [18.2%] versus 3 [3.9%];P=0.005), fewer discharges (32 [48.5%] versus 60 [77.9%];P<0.001), and more deaths (23 [34.8%] versus 9 [11.7%];P=0.001). The sentence "… a high prevalence of DVT and an association between DVT andCURB-65 scores (3-5), Padua scores, and D-dimer levels in hospitalized patients with COVID-19" should be changed to "a high prevalence of DVT on ultrasound scans and an association between DVT and CURB-65 score 3 to 5, Padua prediction score ≥4, and D-dimer >1.0 in hospitalized patients with COVID-19".5.The sentence "and series of patients in ICUs (without COVID19) reported from China" should be changed to "and series of patients in ICUs (without COVID-19) reported from China".6.The sentence "We recorded all levels of DVTs and found that 43 (65%) patients had thromboses only in the distal intramuscular veins" should be changed to "We recorded all levels of DVTs and found that 43 (65.2%)patients had thromboses only in the distal intramuscular veins".7. The sentence "We also found that 54/87 (88.5%) of patients with a D-dimer…", needs to be change into "We also found that 54/87 (62.1%) of patients with a D-dimer…" 8. Figure 1 has been updated to reflect these clarifications.
SOCIETY NEWS.
Authors: Charles R. Dickson
Journal: JAMA (1895)

<h3>American Academy of Railway Surgeons, Meeting of the Publication Committee.</h3> —Pursuant to the call of the President, Dr. C. K. Cole, Helena, Mont., Drs. C. B. Kibler, Corry, Pa; W. J. Galbraith,Omaha, Neb.; R. Harvey Reed, Columbus, Ohio; C. M. Daniels, Buffalo, N. Y., and Webb J. Kelly, Galion, Ohio, met June 1, at Galion, Ohio, to arrange the preliminary work for the coming session of the American Academy of Railway Surgeons. After considerable discussion, the date of the meeting was set for September 25, 26, and 27. This was thought advisable on account of the previous date conflicting with those of other prominent associations; and again, on account of the excessive heat at that season of the year. It was decided to request Chairman Bevan of the Arrangement Committee, to engage headquarters and hotel accommodations at one of the leading hotels in Chicago. The classification of the program was
Queries and Minor Notes
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>COVID-19 Stats:</i> COVID-19* and Influenza† Discharge Diagnoses as a Percentage of Emergency Department (ED) Visits,§ by Year — United States, June 2018–March 2021
Journal: MMWR Morbidity and Mortality Weekly Report (2021)

Percentage of ED visits * COVID-19 visits were identified using International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) and SNOMED Clinical Terms (SNOMED CT) diagnosis codes.ICD-10-CM codes included U07.1, COVID-19 and J12.82 (pneumonia due to coronavirus disease 2019).SNOMED CT codes included 840539006 (disease caused by SARS-CoV-2 [disorder]), 840544004 (suspected disease caused by SARS-CoV-2 [situation]), and 840533007 (SARS-CoV-2 [organism]). † Influenza visits were identified using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM), ICD-10-CM, and SNOMED CT diagnosis codes.ICD-9-CM codes included those beginning with 487 (influenza) and 488.01, 488.09, 488.11, 488.19, 488.81, and 488.89 (influenza due to certain identified influenza viruses with pneumonia and other manifestations).ICD-10-CM codes included those that start with J09 (influenza due to certain identified influenza viruses), J10 (influenza due to other identified influenza virus), and J11 (influenza due to unidentified influenza virus).SNOMED CT codes included 442696006 (influenza caused by influenza A virus subtype H1N1 [disorder]); 442438000 (influenza caused by influenza A virus [disorder]), 24662006 (influenza caused by influenza B virus [disorder]), 6142004 (influenza [disorder]), and 195878008 (pneumonia and influenza [disorder]).§ Data include ED visits from 71% of U.S. facilities in all states except Hawaii; some states have a higher proportion of facilities sending data than others.Data are presented as ED visits for influenza or COVID-19 as the weekly percentage of all ED visits during June-March for a given year.In late June 2020, the percentage of ED visits for COVID-19 increased and reached a peak of 2.8% of all ED visits in early July before declining through August.This decline was followed by a larger and more prolonged increase beginning in September 2020 that reached a peak (7.2%) in early January 2021.Influenza activity generally begins in October with increased activity throughout the winter months.By the beginning of February 2018, the percentage of ED visits for influenza reached 3.1%, and by the beginning of February 2019, reached 5.0%.During June 2020-March 2021, ED visits for influenza accounted for less than 0.1% of all visits.
The mystery of the mitochondria
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RADIO-ACTIVE SUBSTANCES BILL: Correction
Journal: BMJ (1947)

pension shall be brought into account, under certain circumstances, in assessing his total pay.This again may be justified in the case of a non-contributory Civil Service pension but is utterly unjustified in the case of a contributory scheme, where the practitioner has paid for his pension and is entitled to that pension by right and without any conditions attached.Even a policeman who engages in remunerative employment after his retirement is not the victim of any means test such-as this.-I am, etc., Leeds.
Statistical Studies on Skeletal Tuberculosis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase 1b study of vactosertib in combination with nal-IRI plus 5FU/LV in patients with metastatic pancreatic ductal adenocarcinoma who have failed first-line gemcitabine/<i>nab</i>-paclitaxel.
Authors: Joon Oh Park, Seung Tae Kim, Jung Yong Hong, Seong-Jin Kim, Young Suk Park
Journal: Journal of Clinical Oncology (2022)

TPS632 Background: Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive malignancies and the leading cause of cancer-related death in the world, although recent advances in chemotherapies for metastatic PDAC provide better clinical outcomes. TGF-β is strongly involved in the tumor microenvironment of PDAC, and dysregulation of TGF-β signaling is a frequent molecular disturbance in PDAC progression and metastasis. Vactosertib is an orally bioavailable TGF-β signaling inhibitor that targets the TGF-β type I receptor kinase. In in vivo studies, vactosertib reduces cancer cell migration, invasion, and metastasis of various cancers, and combination of vactosertib with nal-IRI/5-FU/LV improves pancreatic cancer survival by suppressing cell migration, invasion, and epithelial-mesenchymal transition (EMT), highlighting a potential clinical application of this approach for PDAC patients (Hong et al, 2020). Based on this preclinical study, we develop a phase 1b study to determine the recommended phase 2 dose (RP2D) and to evaluate the safety of vactosertib in combination with nal-IRI/5FU/LV in patients with metastatic PDAC who have failed first-line gemcitabine/ nab-paclitaxel. Methods: Eligible patients have histologically confirmed PDAC who have failed first-line gemcitabine/ nab-paclitaxel with adequate organ function and performance status. This study is composed of two parts; dose escalation and dose expansion. In the dose escalation part (phase 1b), different dose levels of vactosertib (100 mg bid, 200 mg bid, and 300 mg bid) for escalation will be tested, starting with dose level 0 (DL 0, 200 mg bid) with 3 to 6 subjects recruited in each cohort. DL -1 is only tested when DL 0 is unacceptable. In the dose expansion part, one or two additional backfill cohorts among DL -1 through DL 2 will be opened for determination of the final RP2D. For each cohort, a maximum of 12 patients can be enrolled including the dose escalation and dose expansion phase. Patients in each cohort will receive vactosertib 100-300 mg orally twice per day 1-5 &amp; day 8-12 with nal-IRI 70mg/m 2 intravenously day 1, LV 400mg/m 2 IV day 1, and continuous 5-FU 2400mg/m 2 infusion over 48 hours every 2 weeks. The primary endpoint is to determine RP2D and to evaluate safety of this combination. The key secondary endpoints are progression free survival, overall response rate, disease control rate based on RECIST 1.1 and overall survival. As of September 2021, 5 patients have been enrolled in DL 0 and 1 DLT has been reported in DL 0. This study is prospectively registered on ClinicalTrials.gov, NCT04258072. Clinical trial information: NCT04258072.
SARS: screening, disease associations, and response
Authors: Simon J Baker
Journal: The Lancet (2003)

I have been struck by several features of SARS and feel compelled to raise them following publication of J Peiris and colleagues' study (April 19, p 1319).1Peiris JSM Lai ST Poon LLM et al.Coronavirus as a possible cause of severe acute respiratory syndrome.Lancet. 2003; 361: 1319-1325Summary Full Text Full Text PDF PubMed Scopus (2480) Google Scholar A notable feature of the epidemiology, as reported in the lay media, is that mortality seems confined to adults and is skewed towards older people. Although this trend might be biased by high incidence of nosocomial infections among adult medical workers, it would seem that community-based infection is not resulting in great mortality of infants; an unusual feature for a severe acute viral illness. With the recognition of a coronavirus associated with the syndrome, I was struck by the similarity of SARS with feline infectious peritonitis (FIP). FIP is caused by coronaviruses and has a complex pathogenesis affected by the intrinsic virulence of the viral strain and the host's previous exposure to coronavirus. Peiris and co-workers note that degree of viral replication and later descent into acute respiratory distress syndrome are not correlated, and suggest that immunopathological mechanisms could have a part to play in disease progression. I postulate that previous exposure to coronaviruses might affect the clinical course of the disease, especially the potential for serious immunopathological consequences in the postacute phase. Furthermore, I believe that regional variations in exposure to non-SARS coronavirus could contribute to what seem to be differences in mortality, notably the apparently high mortality in Canada despite access to the full resource of a developed nation's medical system. The risk of being a supershedder might also be affected by the absence of previous exposure to other coronaviruses. A serious implication of the potential role of immunopathology is clearly that vaccination could adversely affect the course of disease after subsequent exposure to wild-type virus.
Irrigated-tip versus 8-mm-tip catheters for radiofrequency ablation of common atrial flutter in patients with structural heart disease: A prospective randomized study Maurizio landolina, Gaetano De Ferrari, Francesco Cant�, Michela Casella, Barbara Petracci. S. Matteo Hospital - IRCCS, Pavia, Italy
Journal: Journal of the American College of Cardiology (2001)