tbuckley/cabot-search huggingface dataset:
The Treatment of Fractures in General Practice.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
When I use a word . . . . Bioscience journals—an open and shut case?
Authors: Jeffrey K Aronson
Journal: BMJ (2022)

The term “open access” as applied to journals, widely and now inescapably used, is misleading. It implies that access to other journals is restricted. The important factor, however, is not openness or restrictedness, but who pays for access, readers and their sponsors (reader-directed access) or authors and their sponsors (author-directed access). Emerging evidence suggests that authors in low income countries can be disadvantaged by current author-directed fees in the open access framework, a problem that needs to be tackled. The recent “diamond” model may be beneficial, but it is much too soon to know.
Very low-calorie diets. National Task Force on the Prevention and Treatment of Obesity, National Institutes of Health
Journal: JAMA (1993)

To provide an overview of the published scientific information on the safety and efficacy of very low-calorie diets (VLCDs) and to provide rational recommendations for their use.Original reports obtained through a MEDLINE search for 1966 through 1992 on VLCDs or reducing diets plus obesity, supplemented by a manual search of bibliographies and the opinions of experts in the field of nutrition and weight loss therapy for obesity. Only studies of humans were cited.Current VLCDs are usually provided in the context of comprehensive treatment programs, during which usual food intake is completely replaced by specific foods or liquid formulas containing 3350 kJ/d (800 kcal/d) or less. Weight loss on VLCDs averages 1.5 to 2.5 kg/wk; total loss after 12 to 16 weeks averages 20 kg. These results are superior to standard low-calorie diets of 5020 kJ/d (1200 kcal/d), which lead to weight losses of 0.4 to 0.5 kg/wk and an average total loss of only 6 to 8 kg. There is little evidence that intakes of less than 3350 kJ/d (800 kcal/d) result in better weight losses than 3350 kJ. Intake of at least 1 g/kg of ideal body weight per day of protein of high biologic value appears to be important in helping to preserve lean body mass. Serious complications of modern VLCDs are unusual, cholelithiasis being most common.Current VLCDs are generally safe when used under proper medical supervision in moderately and severely obese patients (body mass index [weight in kilograms divided by height in meters squared] > 30) and are usually effective in promoting significant short-term weight loss, with concomitant improvement in obesity-related conditions. Long-term maintenance of weight lost with VLCDs is not very satisfactory and is no better than with other forms of obesity treatment. Incorporation of behavioral therapy and physical activity in VLCD treatment programs seems to improve maintenance.
Sleep deficiency as a driver of cellular stress and damage in neurological disorders
Authors: Rochelle L. Coulson, Philippe Mourrain, Gordon X. Wang
Journal: Sleep Medicine Reviews (2022)

Neurological disorders encompass an extremely broad range of conditions, including those that present early in development and those that progress slowly or manifest with advanced age. Although these disorders have distinct underlying etiologies, the activation of shared pathways, e.g., integrated stress response (ISR) and the development of shared phenotypes (sleep deficits) may offer clues toward understanding some of the mechanistic underpinnings of neurologic dysfunction. While it is incontrovertibly complex, the relationship between sleep and persistent stress in the brain has broad implications in understanding neurological disorders from development to degeneration. The convergent nature of the ISR could be a common thread linking genetically distinct neurological disorders through the dysregulation of a core cellular homeostasis pathway.
Deficiency of the kidney tubular angiotensin II type1 receptor–associated protein ATRAP exacerbates streptozotocin-induced diabetic glomerular injury via reducing protective macrophage polarization
Authors: Kotaro Haruhara, Toru Suzuki, Hiromichi Wakui, Kengo Azushima, Daisuke Kurotaki, Wataru Kawase, Kazushi Uneda, Ryu Kobayashi, Kohji Ohki, Sho Kinguchi, Takahiro Yamaji, Ikuma Kato, Kenichi Ohashi, Akio Yamashita, Tomohiko Tamura, Nobuo Tsuboi, Takashi Yokoo, Kouichi Tamura
Journal: Kidney International (2022)
Self‐Assembled Human Skin Equivalents Model Macrophage Activation of Cutaneous Fibrogenesis in Systemic Sclerosis
Authors: Mengqi Huang, Avi Smith, Matthew Watson, Rajan Bhandari, Lauren M. Baugh, Irena Ivanovska, Trishawna Watkins, Irene Lang, Maria Trojanowska, Lauren D. Black, Patricia A. Pioli, Jonathan Garlick, Michael L. Whitfield
Journal: Arthritis & Rheumatology (2022)

Objective The development of precision therapeutics for systemic sclerosis (SSc) has been hindered by the lack of models that accurately mimic the disease in vitro. This study was undertaken to design and test a self‐assembled skin equivalent (saSE) system that recapitulates the cross‐talk between macrophages and fibroblasts in cutaneous fibrosis. Methods SSc‐derived dermal fibroblasts (SScDFs) and normal dermal fibroblasts (NDFs) were cultured with CD14+ monocytes from SSc patients or healthy controls to allow de novo stroma formation. Monocyte donor–matched plasma was introduced at week 3 prior to seeding keratinocytes to produce saSE with a stratified epithelium. Tissue was characterized by immunohistochemical staining, atomic force microscopy, enzyme‐linked immunosorbent assay, and quantitative reverse transcriptase–polymerase chain reaction. Results Stroma synthesized de novo from NDFs and SScDFs supported a fully stratified epithelium to form saSE. A thicker and stiffer dermis was generated by saSE with SScDFs, and more interleukin‐6 and transforming growth factor β (TGFβ) was secreted by saSE with SScDFs compared to saSE with NDFs, regardless of the inclusion of monocytes. Tissue with SSc monocytes and plasma had amplified dermal thickness and stiffness relative to control tissue. Viable CD163+ macrophages were found within the stroma of saSE 5 weeks after seeding. Additionally, SSc saSE contained greater numbers of CD163+ and CD206+ macrophages compared to control saSE. TGFβ blockade inhibited stromal stiffness to a greater extent in SSc saSE compared to control saSE. Conclusion These data suggest reciprocal activation between macrophages and fibroblasts that increases tissue thickness and stiffness, which is dependent in part on TGFβ activation. The saSE system may serve as a platform for preclinical therapeutic testing and for molecular characterization of SSc skin pathology through recapitulation of the interactions between macrophages and fibroblasts.
Thinking More About Inhibition of Breast Milk on the Infectivity of SARS-CoV-2
Authors: Yi-Hua Zhou, Yuqian Luo, Kuanhui Xiang
Journal: JAMA Pediatrics (2022)

Bridget E. Young, PhD; Antti E. Seppo, PhD; Nichole Diaz, BA; Casey Rosen-Carole, MD; Anna Nowak-Wegrzyn, MD, PhD; Joseline M. Cruz Vasquez, MPH; Rita Ferri-Huerta, MD; Phuong Nguyen-Contant, PhD; Theresa Fitzgerald, BA; Mark Y. Sangster, PhD; David J. Topham, PhD; Kirsi M. Järvinen, MD, PhD
Editor’s Choice January 2013
Journal: British Journal of Dermatology (2012)

Distribution pattern of segmental vitiligoVan Geel et al. performed a retrospective observational study comparing the distribution pattern of 724 unilateral, linear or band-shaped control lesions with 181 segmental vitiligo lesions.Clinical photographs were used to score similarities according to a defi ned grading system (scale ranging from 0 for no similarities to 4 for complete similarity).In general, only a minority of cases (36.9%), showed similarities between control lesions and segmental vitiligo.Grade 2-4 similarities were seen mainly in segmental lentiginosis (73.7%, P < 0.001).Th e remarkable clinical similarity with several cases of mosaic diseases involving melanocytes supports the hypothesis that cutaneous mosaicism may be involved in segmental vitiligo.
The Lung
Authors: Jean Bousquet
Journal: Allergy (1995)

•A positive food challenge doesn't imply that there is an IgE mediated allergy but implies the patient is intolerant to certain foods. •If specific IgE and/or prick test to a specific food‐stuff is positive, an IgE‐mediated mechanism is likely to be involved but a proportion of patients with IgE to foods do not present any symptom when ingesting the food.
A DAY FOR MEDICAL WRITING
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Illegible Handwriting in Medical Records
Authors: F Javier Rodríguez-Vera, Y Marín, A Sánchez, C Borrachero, E Pujol
Journal: Journal of the Royal Society of Medicine (2002)

In clinical records many items are handwritten and difficult to read. We examined clinical histories in a representative sample of case notes from a Spanish general hospital. Two independent observers assigned legibility scores, and a third adjudicated in case of disagreement. Defects of legibility such that the whole was unclear were present in 18 (15%) of 117 reports, and were particularly frequent in records from surgical departments. Through poor handwriting, much information in medical records is inaccessible to auditors, to researchers, and to other clinicians involved in the patient's care. If clinicians cannot be persuaded to write legibly, the solution must be an accelerated switch to computer-based systems.
Highlights
Journal: JAMA (2015)

Limited data suggest that folic acid supplementation may be efficacious in the primary prevention of stroke.In a randomized trial that enrolled 20 702 Chinese adults with hypertension and no history of stroke or myocardial infarction, Huo and colleagues tested the hypothesis that enalapril and folic acid would be more effective than enalapril alone in reducing incident stroke risk.During a median treatment duration of 4.5 years, the authors found that combined use of enalapril and folic acid, compared with enalapril alone, significantly reduced the risk of first stroke.In an Editorial, Stampfer and Willett discuss folate supplementation for stroke prevention.
On Pleuritic Effusion
Authors: J. R. Wardell
Journal: BMJ (1874)

Dr. Landry's narrative is followed by remarks of Professor Gubler, which conclude by a statemeint to the effect that a paralysis similar to that which occurs as a sequel of diphtheria may supervene as a secondary result of numerous maladies very different from one another, but all producing exhaustion of the nervous system, impoverishment of the constitution, andi a lowering of organic pow,ver-conditions favourable to the production of permanent disorder of the ininervation.On the appearance of this case, Dr. Macario of Nice laid claim to priority in a communicationi published in the Uniont ITIeVicale of Paris for Nov. 8tl, I859.He there gives the details of four cases of pneumonic paralysis.Dr. MIacario's cases are given in his work on Dy'namzic Par-alysis, which received a meed of honour from the Academy of Sciences of MIont- pellier, and was published in the BIulletinz GW 'ral de The')a/eu/ique for December I850.Maniy authors, wvriting before and since that date, have described cases of pneunmonic paralysis.To priority in the publication of such cases, Professor Gubler lays no claim.The important claim to priority wvhich lhe does put forth is thus expressed: "Le seul merite que je puisse revendiquter est d'avoir le premier, je crois, eleve' au rang de fait general la production des paralysies generalisees comme effet secondaire de toutes les affections de courte duree, vraiment dignes par leur intensite duL titre de maladies azi^ues."He explains that, under the term " acute diseases" (maladies aig,ues), he includes only the diseases
Investigation of visceral sensation in humans
Journal: Gut (2002)

Investigation of visceral sensation in humansHypersensitivity in functional gastrointestinal disorders Patients with functional gastrointestinal disorders present with abdominal symptoms which have no apparent organic cause.It has been well established that these patients have a sensory dysfunction that affects exclusively the viscera.However, the extent of the dysfunction in the different clinical syndromes and the origin of visceral hyperalgesia remain obscure.Some data indicate that the sensory dysfunction in these patients is associated with altered reflex activity, and both mechanisms may interact to produce the symptoms, which in each clinical syndrome would depend on the particular pathways that affected.This working hypothesis would explain both the clinical pleomorphism and the frequent overlap of functional gastrointestinal disorders.
Archives of Otolaryngology, Chicago
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NT-proBNP and ICD in Nonischemic Systolic Heart Failure
Authors: Jawad H Butt, Adelina Yafasova, Marie B Elming, Ulrik Dixen, Jens C Nielsen, Jens Haarbo, Lars Videbæk, Eva Korup, Niels E Bruun, Hans Eiskjær, Axel Brandes, Anna M Thøgersen, Finn Gustafsson, Kenneth Egstrup, Christian Hassager, Jesper Hastrup Svendsen, Dan E Høfsten, Christian Torp-Pedersen, Steen Pehrson, Jens Jakob Thune, Lars Køber
Journal: JACC Heart Failure (2022)
Incorrect Definition
Authors: Daniel Yang, Harvey Fineberg, Karen Cosby, Betty Gordon, Betty Moore
Journal: JAMA (2022)

In Reply In response to our recent Viewpoint 1 about diagnostic excellence, Dr Lockshin raises the important consideration of uncertainty in diagnosis, which may express itself as degrees of confidence in possible diagnoses or in the inability to reach a definitive or highly confident diagnosis.Whether the absence of a diagnosis constitutes an error depends on whether the absence stems from the limits of medical knowledge and technology, and therefore reflects a gap in medical science, or whether it represents a failure relative to prevailing knowledge and standards of clinical care.Either as a limit of knowledge or as a failing of clinical action or judgment, uncertainty often accompanies the diagnostic process.
Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO)
Authors: Yuan Shi, Mochen Cui, Katharina Ochs, Matthias Brendel, Felix L. Strübing, Nils Briel, Florian Eckenweber, Chengyu Zou, Richard B. Banati, Guo-Jun Liu, Ryan J. Middleton, Rainer Rupprecht, Uwe Rudolph, Hanns Ulrich Zeilhofer, Gerhard Rammes, Jochen Herms, Mario M. Dorostkar
Journal: Nature Neuroscience (2022)
In older adults, use of a recombinant zoster vaccine was associated with Guillain-Barré syndrome
Authors: Eric B. Larson, Jennifer C. Nelson
Journal: Annals of Internal Medicine (2022)

ACP Journal ClubMarch 2022In older adults, use of a recombinant zoster vaccine was associated with Guillain-Barré syndromeEric B. Larson, MD, MPH, Jennifer C. Nelson, PhDEric B. Larson, MD, MPHKaiser Permanente Washington Health Research Institute, University of Washington, Seattle, Washington, USA (E.B.L., J.C.N.)Search for more papers by this author, Jennifer C. Nelson, PhDKaiser Permanente Washington Health Research Institute, University of Washington, Seattle, Washington, USA (E.B.L., J.C.N.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/J22-0010 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationGoud R, Lufkin B, Duffy J, et al. Risk of Guillain-Barré syndrome following recombinant zoster vaccine in Medicare beneficiaries. JAMA Intern Med. 2021;181:1623-30. https://pubmed.ncbi.nlm.nih.gov/34724025Clinical Impact RatingsGIM/FP/GP: Geriatrics: Author, Article, and Disclosure InformationAffiliations: Kaiser Permanente Washington Health Research Institute, University of Washington, Seattle, Washington, USA (E.B.L., J.C.N.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=J22-0010.This article was published at Annals.org on 1 March 2022. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics March 2022Volume 175, Issue 3Page: JC35KeywordsDatabasesDisclosureFood and Drug AdministrationGuillain-Barre syndromeMedicaidMedicarePositive predictive valueSafetySystems biologyVaccines ePublished: 1 March 2022 Issue Published: March 2022 Copyright & PermissionsCopyright © 2022 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Breast Cancer
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Better artificial arms under development
Authors: J. Elliott
Journal: JAMA (1980)

An expression of intense concentration on his face, a scientist at the Illinois Institute of Technology (IIT), Chicago, sits before an artificial arm mounted on a table in his laboratory. Two electrodes attached to his own upper arm channel impulses into a microcomputer that in turn can activate tiny motors in the prosthesis. Without physically moving his limbs, the IIT engineer can flex the elbow of the experimental prosthesis, turn the wrist and, in an almost eerie manner, open and close the lifelike fist. The engineer's own body is whole, but his work with artificial limbs controlled by electrical impulses from the brain promises much-improved function for amputees, persons with congenital malformations, and even stroke victims and paralyzed patients. The investigator is Daniel Graupé, PhD, professor of engineering at IIT. Though muscle-activated artificial limbs have been in use and even sold commercially for more than ten years, the work of
Reply to Johanna Noel, Olivier Huillard, and Francois Goldwasser’s Letter to the Editor re: Keiichiro Mori, Mohammad Abufaraj, Hadi Mostafaei, et al. The Predictive Value of Programmed Death Ligand 1 in Patients with Metastatic Renal Cell Carcinoma Treated with Immune-checkpoint Inhibitors: A Systematic Review and Meta-analysis. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.10.006. Clinical Activity of Immune Checkpoint Inhibitors: Is the Host the Answer?
Authors: Keiichiro Mori, Manuela Schmidinger, Shin Egawa, Kilian M. Gust, Shahrokh F. Shariat
Journal: European Urology (2021)
Contents: (Adv. Healthcare Mater. 7/2013)
Journal: Advanced Healthcare Materials (2013)

The excellent cytocompatibility of singlelayer CVD graphene is demonstrated by showing that primary adult retinal ganglion cells can directly survive on its surface without any supporting glial layer or protein coating.These results confi rm the great potential of graphene as a biocompatible material for interfacing neurons, opening a new route for the development of a novel generation of fl exible and highsensitive neural prostheses.