tbuckley/cabot-search huggingface dataset:
AB0248 PREVALENCE OF THYROID PEROXIDASE ANTIBODIES IN THE NORMAL POPULATION AND IN PATIENTS WITH RHEUMATOID ARTHRITIS AND THEIR PREDICTIVE VALUE FOR THE EFFECTIVENESS OF TREATING RHEUMATOID ARTHRITIS
Authors: M. Kedves, J. Csitos, K. Törőcsik, A. Rideg, I. G. Makkos, D. Balaton, A. Ozsvár, L. Farkas, J. Gál
Journal: Annals of the Rheumatic Diseases (2020)

Background: Rheumatoid arthritis (RA) is sometimes associated with autoimmune thyroid disease (AITD) 1 . However the relation between RA autoantibodies and thyroid autoantibodies is doubtful. However, there is no reliable data on whether concomitant positivity of level of anti-TPO in rheumatoid arthritis patients alters the efficacy of RA therapy. Objectives: To study the presence of level of autoimmune thyroid markers (thyroid peroxidase antibodies -anti-TPO-), in clinically and serologically different forms of RA, compared to serum level of anti-TPO in control population, and to study whether anti-TPO positivity in any RA group influences the risk of high disease activity and also affects the likelihood of achieving DAS-28 remission. Methods: 1428 patients were included in the retrospective single-center study using the database of the Arthritis Registry of Kecskemét (ARK). 772 RA patients, subclassified according to the presence of RF and anti-MCV into seropositive RA patients (positive to one or both seromarkers), and seronegative RA (negative to both seromarkers), and 656 patients were included as control group without autoimmune diseases. Results: Elevated level of anti-TPO was found in 199/772 (26%) RA patients, compared to controls 32% (209/656). Furthermore, the level of anti-TPO was similar in seropositive and seronegative groups (24% and 27% respectively). RA patients treated with biological therapy presented higher level of anti-TPO in 28%, similarly to RA patients without biological therapy (24%). There was no relevant difference in level of anti-TPO among the groups with different disease activity (high activity: DAS28 &gt; 5.1; - 24%; moderate activity: DAS28 ≤5.1; &gt; 3.2; - 25%; and in low activity DAS28 ≤ 3.2; - 28% respectively). Conclusion: Our present data show that the elevated level of anti-TPO is similarly in patients with serologically different forms of RA and in the control group. The presence of anti-TPO antibody does not affect the severity of RA and the results obtained with the treatment, including that anti-TPO positivity does not increase the need for biological therapy. References: [1]Soliman E, Ghitany K, Bondok M, et al AB0343 Thyroid Autoantibodies in Seropositive Versus Seronegative Rheumatoid Arthritis: Is There a Link? Annals of the Rheumatic Diseases 2015;74:1008. Disclosure of Interests: None declared
Fluid administration and monitoring in ARDS: which management?
Authors: Philippe Vignon, Bruno Evrard, Pierre Asfar, Mattia Busana, Carolyn S. Calfee, Silvia Coppola, Julien Demiselle, Guillaume Geri, Mathieu Jozwiak, Greg S. Martin, Luciano Gattinoni, Davide Chiumello
Journal: Intensive Care Medicine (2020)
Evaluation of ROR1 Targeted Antibody Drug Conjugates in Acute and Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma
Authors: Eileen Hu, Priscilla Do, Rajeswaran Mani, Frank Frissora, Haiyong Peng, Lorenz Waldmeier, Roger Beerli, Christoph Rader, Ulf Grawunder, John C. Byrd, Natarajan Muthusamy
Journal: Blood (2017)
Abstract PO-002: Detection of chemotherapy-resistant pancreatic cancer using a glycan Biomarker
Authors: ChongFeng Gao, Luke Wisniewski, Ying Liu, Ben Staal, Ian Beddows, Dennis Plenker, Mohammed Aldakkak, Johnathan Hall, Daniel Barnett, Mirna Kheir Gouda, Peter Allen, Richard Drake, Amer Zureikat, Ying Huang, Douglas Evans, Aatur Singhi, Randall Brand, David Tuveson, Susan Tsai, Brian Haab
Journal: Cancer Research (2020)

Abstract A subset of pancreatic ductal adenocarcinomas (PDACs) is highly resistant to systemic chemotherapy, but no markers are available in clinical settings to identify this subset. In this study, we evaluate the role of sTRA, a glycan biomarker for PDAC, in predicting chemotherapeutic responses. We tested the correlation between chemosensitivity and glycan expression in PDACs in multiple systems including sets of cell lines, organoids, and isogenic cell lines; primary tumors; and blood plasma from human subjects. The sTRA-expressing models tended to have stem-like gene expression and the capacity for mesenchymal differentiation, in contrast to the non-expressing models. The sTRA cell lines also had significantly increased resistance to seven different chemotherapeutics commonly used against pancreatic cancer. Patients with primary tumors that were positive for a gene-expression classifier for sTRA received no statistically significant benefit from adjuvant chemotherapy, in contrast to those negative for the signature. In another cohort, based on direct measurements of sTRA in tissue microarrays, the patients who were high in sTRA again had no statistically significant benefit from adjuvant chemotherapy. Furthermore, a blood-plasma test for the sTRA glycan identified the PDACs that showed rapid relapse following neoadjuvant chemotherapy. This research demonstrates that a glycan biomarker could have value to detect chemotherapy resistant PDAC in clinical settings. This capability could aid in the development of stratified treatment plans and facilitate biomarker-guided trials targeting resistant PDAC. Citation Format: ChongFeng Gao, Luke Wisniewski, Ying Liu, Ben Staal, Ian Beddows, Dennis Plenker, Mohammed Aldakkak, Johnathan Hall, Daniel Barnett, Mirna Kheir Gouda, Peter Allen, Richard Drake, Amer Zureikat, Ying Huang, Douglas Evans, Aatur Singhi, Randall Brand, David Tuveson, Susan Tsai, Brian Haab. Detection of chemotherapy-resistant pancreatic cancer using a glycan Biomarker [abstract]. In: Proceedings of the AACR Virtual Special Conference on Pancreatic Cancer; 2020 Sep 29-30. Philadelphia (PA): AACR; Cancer Res 2020;80(22 Suppl):Abstract nr PO-002.
When the Stomach Rules the Heart: Dyspnea as a Neglected Complication of a Large Hiatal Hernia⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Authors: Thomas H. Marwick
Journal: Journal of the American College of Cardiology (2011)
Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial
Authors: Phillip D Monk, Richard J Marsden, Victoria J Tear, Jody Brookes, Toby N Batten, Marcin Mankowski, Felicity J Gabbay, Donna E Davies, Stephen T Holgate, Ling-Pei Ho, Tristan Clark, Ratko Djukanovic, Tom M A Wilkinson, Michael G Crooks, Davinder PS Dosanjh, Salman Siddiqui, Najib M Rahman, Jacklyn A Smith, Alexander Horsley, Timothy W Harrison, Dinesh Saralaya, Lorcan McGarvey, Alastair Watson, Edmund Foster, Adam Fleet, Dave Singh, Sophie Hemmings, Sandra Aitken, Sarah Dudley, Rona Beegan, Angela Thompson, Pedro MB Rodrigues
Journal: The Lancet Respiratory Medicine (2020)
Abstract 16340: Atrial Wall Thickness Features Predefine Human Right Atrial Driver: Insights Gained From Novel Structural Analysis
Authors: Jichao Zhao, Aleksei Mikhailov, Megan Subr, Aaqel Nalar, James Kennelly, nawshin dastagir, Roshan Sharma, Anuradha Kalyanasundaram, Ning LI, Brian Hansen, Bryan Whitson, John Hummel, Vadim V Fedorov
Journal: Circulation (2020)

Introduction: Atrial fibrillation (AF) is not effectively treated in clinics due to a lack of adequate tools for identifying AF drivers as targets in ablation treatment. Recent studies revealed that 30-50% of patients with persistent AF have drivers not only in the left atrium (LA) but also in the right atrium (RA). However, the precise substrate underlying RA AF drivers remains elusive. Hypothesis: High-resolution analysis of human atrial wall 3D structure can predict the occurrence of right atrial drivers. Methods: Coronary perfused explanted human atria (N=10, 46.2±14.7 y.o.;40% female) were optically mapped with high-resolution CMOS cameras. Sustained AF was induced by fast pacing and perfusion of adenosine and/or isoproterenol. Hearts were imaged at ~170μm 3 resolution by 9.4T gadolinium-enhanced MRI (Fig. A). A coupled PDE approach was utilized to estimate the atrial wall thickness (Fig. B). Fibrosis was identified above a signal intensity threshold validated by histology; and fibrosis density was constructed for each voxel by determining the percent of neighboring fibrotic voxels within a radius of 5 voxels. Results: Optical mapping identified 9 RA drivers in 6 hearts (H1-6) and 7 LA drivers in 5 hearts (H5, 6 and 8-10, Fig. C). All 9 RA AF drivers were anchored in myobundle structure in close proximity to the crista terminalis (CT). Wall thickness distribution in RA excluding the CT was similar to that in the LA (N=10, Fig. D). Structural analysis showed that RA with AF drivers (N=6) was thicker with greater wall variation and higher fibrosis density than RA without AF drivers (N=4, Fig. E). Furthermore, RA driver regions (N=9) were thicker and varied more than other RA regions (4.64±2.86 mm vs 4.56±2.57mm, p&lt;0.05). Conclusions: For the first time, the 3D structural analysis demonstrates that structural features including atrial wall thickness and its variation near the CT can predict RA driver occurrences in human hearts and be used to improve targeted ablation.
Piecemeal cold snare polypectomy versus conventional endoscopic mucosal resection for large sessile serrated lesions: a retrospective comparison across two successive periods
Authors: W Arnout van Hattem, Neal Shahidi, Sergei Vosko, Imogen Hartley, Kaushali Britto, Mayenaaz Sidhu, Iddo Bar-Yishay, Scott Schoeman, David James Tate, Karen Byth, David G Hewett, María Pellisé, Luke F Hourigan, Alan Moss, Nicholas Tutticci, Michael J Bourke
Journal: Gut (2020)

Large (≥20 mm) sessile serrated lesions (L-SSL) are premalignant lesions that require endoscopic removal. Endoscopic mucosal resection (EMR) is the existing standard of care but carries some risk of adverse events including clinically significant post-EMR bleeding and deep mural injury (DMI). The respective risk-effectiveness ratio of piecemeal cold snare polypectomy (p-CSP) in L-SSL management is not fully known.Consecutive patients referred for L-SSL management were treated by p-CSP from April 2016 to January 2020 or by conventional EMR in the preceding period between July 2008 and March 2016 at four Australian tertiary centres. Surveillance colonoscopies were conducted at 6 months (SC1) and 18 months (SC2). Outcomes on technical success, adverse events and recurrence were documented prospectively and then compared retrospectively between the subsequent time periods.A total of 562 L-SSL in 474 patients were evaluated of which 156 L-SSL in 121 patients were treated by p-CSP and 406 L-SSL in 353 patients by EMR. Technical success was equal in both periods (100.0% (n=156) vs 99.0% (n=402)). No adverse events occurred in p-CSP, whereas delayed bleeding and DMI were encountered in 5.1% (n=18) and 3.4% (n=12) of L-SSL treated by EMR, respectively. Recurrence rates following p-CSP were similar to EMR at 4.3% (n=4) versus 4.6% (n=14) and 2.0% (n=1) versus 1.2% (n=3) for surveillance colonoscopy (SC)1 and SC2, respectively.In a historical comparison on the endoscopic management of L-SSL, p-CSP is technically equally efficacious to EMR but virtually eliminates the risk of delayed bleeding and perforation. p-CSP should therefore be considered as the new standard of care for L-SSL treatment.
Abstract 13467: Vasodilatation Stress Cardiovascular Magnetic Resonance: Feasibility and Safety in a Monocentric Prospective Study
Authors: Theo Pezel, Philippe Garot, Thomas Hovasse, Thierry Unterseeh, Solenn Toupin, Marie Claude Morice, Stephane Champagne, Yves Louvard, Francesca Sanguineti, Jerome Garot
Journal: Circulation (2020)

Introduction: Cardiovascular magnetic resonance imaging (CMR) has emerged as an accurate technique that can assess ventricular function, stress myocardial perfusion, and viability, without radiation. Recent studies have shown that stress CMR would be the best test to predict obstructive coronary artery disease (CAD) with a good safety. Hypothesis: To assess the feasibility and incidence of immediate complications of stress CMR in a tertiary Cardiovascular Center with CMR Laboratory dedicated. Methods: Prospective registry of vasodilator stress CMR in a French center with CMR expertise included all consecutive patients referred for vasodilator stress perfusion CMR to detect an obstructive CAD between 2008 and 2020. Stress CMR was performed at 1.5 T using dipyridamole. The clinical and demographic data, quality of test, CMR findings, haemodynamic data, and complications were prospectively recorded. Results: Stress CMR was performed in 35,157 patients (98.2% of requested). The study could not be performed due to claustrophobia in 0.3%. Quality was optimal in 93.1%, suboptimal in 6.4%, and poor in 0.5% of studies. Images were diagnostic in 97.9% of patients. No patient died or had acute myocardial infarction during the test. Moreover, 56 patients (0.16%) had severe immediate complications, and one anaphylactic shock post-gadolinium. The only factor significantly associated with higher incidence of serious complications was the detection of inducible ischaemia (p&lt;0.001). Incidence of non-severe complications was low (1.5%), severe controlled chest pain being the most frequent. Minor symptoms occurred frequently (35.5%). Conclusions: Performance of stress CMR is safe with very high image rate of satisfactory quality to perform the diagnosis in a referral population. Inducible ischaemia was the only factor identified which was associated with serious complications.
Abstract 14631: Assessment and Resolution of Complex Coronary Configurations by the Multi-artery Fractional Flow Reserve Method
Authors: Ilan A Yaeger
Journal: Circulation (2020)

Introduction: Statistical studies have shown that an FFR method is superior to the traditional coronary assessment method based on angiographic appearance. The current FFR-oriented methods (resting P d / P a , wave-free iFR and hyperemic FFR) however, share a common downside: They do not consider inter arterial interactions and therefore cannot resolve multi-artery configurations, a vital capability provided by the novel multi-artery FFR method. Methods: An independent stand-alone stenotic coronary artery is characterized by its intrinsic FFR (denoted FFR true ). In a multi-artery configuration however, it is influenced by interconnected arteries and the treatment decision criteria apply to the actual FFR (denoted FFR real ) that reflects the arterial current condition. Seeking an optimal resolution of a stenotic configuration, outcomes (FFR true and FFR real ) of optional revascularizations are predicted and evaluated by the multi-artery FFR method. Results: In this work the multi-artery FFR method is applied to the stenotic unprotected configuration LMCA-LCx-LAD-M 2 (second obtuse marginal). The initial characteristics of the configuration are: FFR true (LMCA)=0.87 FFR true (LCx)=0.76 FFR true (LAD)=0.92 FFR true (M 2 )=0.93 FFR real (LMCA)=0.75 FFR real (LCx)=0.67 FFR real (LAD)=0.82 FFR real (M 2 )=0.63 After optimal resolution (by hyperemic FFR criteria), the final characteristics are: FFR true (LMCA)=0.87 FFR true (LCx)=1.00 FFR true (LAD)=1.00 FFR true (M 2 )=0.93 FFR real (LMCA)=0.87 FFR real (LCx)=0.87 FFR real (LAD)=0.87 FFR real (M 2 )=0.80 Conclusions: This work shows that a prerequisite for a successful resolution of a stenotic coronary configuration is a prior numerical simulation of the whole process in which the multi-artery FFR method is applied to the measured intracoronary pressures. This holds for each FFR-oriented method, preserving its specific experimental technique and treatment decision criteria. In conclusion, the multi-artery FFR method has the potential to introduce the PCI practice into an all new era in which the practitioner can devise a resolution strategy and test it by predicting outcomes (in terms of FFR true and FFR real of the arteries) of potential revascularizations, prior to actual implementation.
Implications of Early Health Care Spending Reductions for Expected Spending as the COVID-19 Pandemic Evolves
Authors: J. Michael McWilliams, Ali Russo, Ateev Mehrotra
Journal: JAMA Internal Medicine (2020)

This cohort study examines how early spending changes vary by incidence of coronavirus disease 2019 and how implementation of policies to limit transmission affect health care spending as the pandemic evolves.
Abstract 13508: Left Ventricular Contractile and Kinetic Changes in Failing Human Myocardium Due to Anthracycline Toxicity
Authors: Mohammed Mashali, Nancy Saad, Salome Kiduko, Kyra Peczkowski, Amanda Huang, Farbod Fazlollahi, Austin Hare, Gina Torres Matias, Bryan Whitson, Nahush Mokadam, Courtney Campbell, Paul Janssen
Journal: Circulation (2020)

Introduction: Anthracyclines are used effectively to treat many cancers. However, cumulative and irreversible cardiotoxicity can limit anthracyclines’ clinical benefit. Mechanisms of cardiotoxicity have been assessed in murine models, but no studies directly assess human heart contractility. Our objective was to assess left ventricular contractile force, kinetics of contraction and relaxation, and frequency-dependent activation in anthracycline-induced failing human myocardium. Methods: From 2009-2019, we assessed live tissue-level contractile forces and kinetics in isolated left ventricular intact trabeculae from failing and non-failing human hearts. After the trabeculae were transferred to and stabilized in a custom setup, baseline contractile force and kinetic parameters were assessed at 1 Hz (normal resting in vivo heart rate), followed by frequency-dependent activation (0.5-3.0 Hz) under near-physiological conditions. Retrospectively, we analyzed muscles from three cohorts of individuals: (1) with non-ischemic cardiomyopathy due to anthracycline toxicity (NICM-AC; n =14), (2) with NICM and history of cancer without anthracycline or known cardiotoxic treatments (NICM; n =14), and (3) with non-failing myocardium and no history of cancer (NF; n =14). Results: At stimulation of 1 Hz, active developed force (Fdev) of NICM-AC trabeculae was significantly lower than NF and NICM trabeculae. NICM-AC trabeculae exhibited prolonged 90% relaxation time (RT90), significantly slower maximal rate of force decay (-dF/dt), and slower maximal kinetic rate of relaxation (-dF/dt/Fdev). In addition, frequency-dependent activation and relaxation were markedly impaired in both failing groups. Conclusions: Human myocardium failing due to anthracycline toxicity had significantly decreased force and slower relaxation kinetics compared to non-ischemic failing myocardium. With increase in stimulation frequency, anthracycline treated myocardium exhibited impaired activation and relaxation kinetics. These findings suggest that cardio-protection strategies should aim to improve not only contractile force, but also kinetics of relaxation.
Abstract 15439: Lesion Complexity and Long-term Outcomes According to Mean Observed Blood Pressure After Percutaneous Coronary Intervention
Authors: Jong Il Park, Byung Jun Kim, Hun Tae Kim, Jung Hee Lee, Ung Kim, Jong Seon Park
Journal: Circulation (2020)

Background: The guideline recommended strict blood pressure (BP) control for the patients treated with percutaneous coronary intervention (PCI). We aimed to evaluate the relationship between mean observed BP and long-term outcomes for patients with or without lesion complexity. Methods: A total of 1,470 patients who underwent PCI were investigated. We categorized the study population into four groups based on mean observed BP and lesion complexity (left main &amp; three-vessel disease, chronic total occlusion, total stent length ≥60mm, or bifurcation two stenting): Group A (non-complex &amp; systolic BP ≤120mmHg, n=310), Group B (non-complex &amp; systolic BP &gt;120mmHg, n=674), Group C (complex &amp; systolic BP ≤120mmHg, n=131), and Group D (complex &amp; systolic BP &gt;120mmHg, n=355). We evaluated major adverse cardiovascular and cerebrovascular events (MACCEs), defined as cardiac death, myocardial infarction (MI), repeat target vessel revascularization, or stroke. Results: Well-controlled BP group (Group A&amp;C) showed significantly lower systolic BP than uncontrolled BP group (Group B&amp;D) (114.3±6.1mmHg vs. 130.7±7.6mmHg, p&lt;0.001). MACCEs occurred less frequently in Group A (18.9%) than Group B (23.6%), Group C (22.7%), and Group D (33.6%) (p=0.001) at 8 years. After multivariate analysis, with Group A as a reference, the adjusted hazard ratio (HR) for MACCEs was 1.382 (95% confidence interval [CI] 0.978-1.954, p=0.067) for Group B, 1.559 (95% CI 0.957-2.540, p=0.075) for Group C, and 1.872 (95% CI 1.296-2.705, p=0.001) for Group D. In Cox regression model, although lesion complexity was not associated with MACCE, systolic BP≤120mmHg was an independent predictor for reduced rate of MACCE (HR 0.667, 95% CI 0.485-0.918, p=0.013). Conclusions: Mean observed systolic BP ≤120mmHg after PCI was independent predictor for reduced MACCEs regardless of lesion complexity. Key Words: Blood Pressure; Percutaneous Coronary Intervention; Lesion Complexity; Treatment Outcome
Abstract 14623: Phase Angle as an Indicator of Sarcopenia, Undernutrition, and Cachexia in Inpatients With Cardiovascular Diseases
Authors: Suguru Hirose, Toshiaki Nakajima, Akiko Haruyama, Tomohiro Yasuda, Suomi Yamaguchi, Shigeru Toyoda, Ikuko Shibasaki, Hirotsugu Fukuda, Teruo Inoue
Journal: Circulation (2020)

Introduction: In patients with heart failure, malnutrition is often associated with sarcopenia, and cachexia, closely related to the prognosis of the disease. Phase angle(PA) is an angle that expresses the resistance of the cell membrane, and is related to the health of the cell and the nutritional state of the cell membrane. It is attracting attention as a prognostic factor and nutritional index for various diseases. We investigated the clinical usefulness of PA as markers of sarcopenia, cachexia and malnutrition in hospitalized patients with cardiovascular disease. Methods: Total 412 patients(277 males and 135 females) who underwent cardiac rehabilitation on admission due to cardiovascular diseases were included in this study. We performed body composition analysis(Inbody S10) such as PA, and skeletal muscle mass index(SMI). The nutritional states were evaluated by BMI, CONUT score, blood albumin level(Alb), and Hb. The blood concentration of BNP and eGFR were also measured. Sarcopenia was judged by the AWGS algorithm, and cachexia was judged by using BMI&lt;20 and serum parameters of Alb, Hb, and CRP. Results: Both SMI and PA negatively correlated with age, and positively correlated with BMI, grip strength, knee extension strength, and SPPB score in both sexes. SMI and PA were also significantly associated with CONUT score, Hb, and Alb in males, but PA was more strongly associated with these nutritional aspects. In females, PA was correlated with Hb and Alb, but not with SMI. Sarcopenia was found in 31.6% of men and 32.4% of women. The cut-off values of PA obtained from the ROC curve in patients with sarcopenia were 4.55°for males and 4.25°for females. The cut-off values for PA in ROC curves for those with cachexia were 4.15°for males and 4.25°for females. When grip strength, knee extension strength, CRP, BNP, eGFR, Hb, and Alb were independent factors, multiple regression analysis showed that grip strength and BNP were the independent determinants of SMI, whereas grip strength, BNP, and Hb were the independent determinants of PA, after adjusting for age and BMI in males. Conclusions: This study provides the evidence showing that PA can be highly useful as a marker for sarcopenia, malnutrition and then cachexia in hospitalized patients with cardiovascular disease.