Colorectal Cancer Screening in Young Adults: About Carcinoid Tumors and Cancer
Authors: Michael Bretthauer, Mette Kalager, David S. Weinberg
Journal: Annals of Internal Medicine (2020)

EditorialsFebruary 2021Colorectal Cancer Screening in Young Adults: About Carcinoid Tumors and CancerMichael Bretthauer, MD, PhD, Mette Kalager, MD, PhD, and David S. Weinberg, MD, MScMichael Bretthauer, MD, PhDUniversity of Oslo and Oslo University Hospital Oslo, Norway, Mette Kalager, MD, PhDUniversity of Oslo and Oslo University Hospital Oslo, Norway, and David S. Weinberg, MD, MScFox Chase Cancer Center Philadelphia, PennsylvaniaAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M20-7244 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In May 2018, the American Cancer Society (ACS) issued a new recommendation to start screening for colorectal cancer (CRC) at age 45 rather than 50 years in persons at average risk (1). That guideline increased the number of Americans eligible for screening by 22 million and prompted many questions about risks and benefits for patients as well as the consequences for providers and the health care system.The revised ACS guidance relied on analyses of the SEER (Surveillance, Epidemiology, and End Results) database highlighting a 22% relative increase in CRC incidence from 2000 to 2013 in persons aged 40 to ...References1. Wolf AMD, Fontham ETH, Church TR, et al. Colorectal cancer screening for average-risk adults: 2018 guideline update from the American Cancer Society. CA Cancer J Clin. 2018;68:250-81. [PMID: 29846947] doi:10.3322/caac.21457 Google Scholar2. Siegel RL, Miller KD, Fedewa SA, et al. Colorectal cancer statistics, 2017. CA Cancer J Clin. 2017;67:177-93. [PMID: 28248415] doi:10.3322/caac.21395 Google Scholar3. Bretthauer M, Kalager M, Weinberg DS. From colorectal cancer screening guidelines to headlines: beware. Ann Intern Med 2018;169:405-6. doi:10.7326/M18-1720 Google Scholar4. Liang PS, Allison J, Ladabaum U, et al. Potential intended and unintended consequences of recommending initiation of colorectal cancer screening at age 45 years [Editorial]. Gastroenterology. 2018;155:950-4. [PMID: 30138614] doi:10.1053/j.gastro.2018.08.019 Google Scholar5. Montminy EM, Zhou M, Maniscalco L, et al. Contributions of adenocarcinoma and carcinoid tumors to early-onset colorectal cancer incidence rates in the United States. Ann Intern Med. 2021;174:157-66. doi:10.7326/M20-0068 Google Scholar6. Siegel RL, Miller KD, Goding Sauer, et al. Colorectal cancer statistics, 2020. CA Cancer J Clin. 2020;70:145-64. [PMID 32133645] doi:10.3322/caac.21601 Google Scholar7. Kothari ST, Huang RJ, Shaukat A, et al; ASGE Standards of Practice Committee Chair. ASGE review of adverse events in colonoscopy. Gastrointest Endosc. 2019;90:863-76.e33. [PMID: 31563271] doi:10.1016/j.gie.2019.07.033 Google Scholar8. Peterse EFP, Meester RGS, Siegel RL, et al. The impact of the rising colorectal cancer incidence in young adults on the optimal age to start screening: microsimulation analysis I to inform the American Cancer Society colorectal cancer screening guideline. Cancer. 2018;124:2964-73. [PMID:29846933] doi:10.1002/cncr.31543 Google Scholar9. Bell KJL, Doust J, Glasziou P, et al. Recognizing the potential for overdiagnosis: are high-sensitivity cardiac troponin assays an example. Ann Intern Med. 2019;170:259-61. doi:10.7326/M18-2645 Google Scholar10. U.S. Preventive Services Task Force. Draft recommendation statement. Colorectal cancer: screening. Accessed at www.uspreventiveservicestaskforce.org/uspstf/draft-recommendation/colorectal-cancer-screening3#fullrecommendationstart on 27 October 2020. Google Scholar11. Fedewa SA, Siegel RL, Goding Sauer, et al. Colorectal cancer screening patterns after the American Cancer Society's recommendation to initiate screening at age 45 years. Cancer. 2020;126:1351-3. [PMID:31850529] doi:10.1002/cncr.32662 Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Oslo and Oslo University Hospital Oslo, NorwayFox Chase Cancer Center Philadelphia, PennsylvaniaDisclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M20-7244.Corresponding Author: Michael Bretthauer, MD, PhD, Institute of Health and Society, Department of Health Management and Health Economics, University of Oslo, Postbox 1089 Blindern, 0318 Oslo, Norway; e-mail, michael.[email protected]uio.no.Current Author Addresses: Drs. Bretthauer and Kalager: Institute of Health and Society, Department of Health Management and Health Economics, University of Oslo, Postbox 1089 Blindern, 0318 Oslo, Norway.Dr. Weinberg: Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111.This article was published at Annals.org on 15 December 2020. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoContributions of Adenocarcinoma and Carcinoid Tumors to Early-Onset Colorectal Cancer Incidence Rates in the United States Eric M. Montminy , Meijiao Zhou , Lauren Maniscalco , Wesal Abualkhair , Michelle Kang Kim , Rebecca L. Siegel , Xiao-Cheng Wu , Steven H. Itzkowitz , and Jordan J. Karlitz Colorectal Cancer Screening in Young Adults Amy B. Knudsen , Carolyn M. Rutter , Reinier G.S. Meester , Iris Lansdorp-Vogelaar , Ann G. Zauber , and Karen M. Kuntz Metrics Cited bySynthesis, in silico and in vitro studies of piperazinyl thiourea derivatives as apoptosis inducer for the treatment of colorectal carcinomaDescripción de la variación en el tiempo del cáncer gastrointestinal en el centro occidente de ColombiaAdenocarcinomas, as Opposed to Carcinoids, Are Primarily Driving Increases in Early-Onset Colorectal Cancer RatesColorectal Cancer Screening in Young AdultsAmy B. Knudsen, PhD, Carolyn M. Rutter, PhD, Reinier G.S. Meester, PhD, Iris Lansdorp-Vogelaar, PhD, Ann G. Zauber, PhD, Karen M. Kuntz, ScD February 2021Volume 174, Issue 2Page: 263-264KeywordsAcute coronary syndromeAdenocarcinomaCancer screeningCarcinoid tumorClinical trialsColorectal cancerHealth economicsRisk managementSurveillance Epidemiology and End ResultsYoung adults ePublished: 15 December 2020 Issue Published: February 2021 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...