tbuckley/cabot-search huggingface dataset:
Relationship between blood flow to ischemic regions and extent of myocardial infarction. Serial measurement of blood flow to ischemic regions in dogs.
Authors: FRivas, F RCobb, R JBache, J CGreenfield
Journal: Circulation Research (1976)

This study was designed to measure early sequential changes in blood flow to ischemic regions after acute coronary occlusion and to determine the relationship between blood flow and the extent of subsequent myocardial infarction. Initial studies were carried out on five dogs which verified using radioisotope-labeled microspheres, 7-10 mum in diameter, to measure changes in blood flow in small myocardial regions after acute coronary artery occlusions. Studies then were carried out on 11 awake dogs chronically prepared with dwelling catheters in the aorta and left atrium and occluders on the left circumflex coronary artery. Microspheres were injected via the left atrial catheter 45 seconds and 2, 6, and 24 hours after complete circumflex coronary occlusion. Six days later myocardial blood flow and the extent of histological infarction were determined for multiple samples from four transmural layers of the entire ischemic zone. Average blood flow to the circumflex region was 0.25 +/- 0.03 (SE), 0.39 +/- 0.05...
Development Of Knowledge-Based Clinical Decision Support System For Patients Included In Colorectal Screening Program
Authors: V Lorenzo-Zúñiga, M Bustamante-Balén, L Argüello, N Alonso, S Cristina, G María, PB Vicente
Journal: Endoscopy (2021)

Aims Clinical Decision Support Systems (CDSSs) have recently attracted attention as a method for minimizing medical errors.Colorectal (CRC) screening programs represent a large volume of procedures that need a follow-up endoscopy. A knowledge-based CDDS (K-CDSS) is a technology which contains clinical rules and associations of compiled data that assist with clinical decision-making tasks. Existing CDSSs are limited. To overcome this limitation we develop a K-CDSS based on variables and clinical rules introduced by medical specialist for management of patients included in CRC screening and surveillance of colorectal polyps.
82P Multicenter analysis of neoadjuvant (chemo-)immunotherapy (C-IO) in stage IIB-IVB non-small cell lung cancer (NSCLC) resulting in curative surgery in routine clinical care (KOMPASS neo OP)
Authors: M. Faehling, C. Meyer zum Büschenfelde, M. Sebastian, H. Witte, M. Ulmer, A. Türk, R. Saetzler, K. Steinestel, W.M. Brueckl, A. Bleckmann
Journal: Journal of Thoracic Oncology (2021)
Benefits of Airway Androgen Receptor Expression in Human Asthma
Authors: Joe G. Zein, Jeffrey M. McManus, Nima Sharifi, Serpil C. Erzurum, Nadzeya Marozkina, Timothy Lahm, Olivia Giddings, Michael D. Davis, Mark D. DeBoer, Suzy A. Comhair, Peter Bazeley, Hyun Jo Kim, William Busse, William Calhoun, Mario Castro, Kian Fan Chung, John V. Fahy, Elliot Israel, Nizar N. Jarjour, Bruce D. Levy, David T. Mauger, Wendy C. Moore, Victor E. Ortega, Michael Peters, Eugene R. Bleecker, Deborah A. Meyers, Yi Zhao, Sally E. Wenzel, Benjamin Gaston
Journal: American Journal of Respiratory and Critical Care Medicine (2021)

Rationale: Androgens are potentially beneficial in asthma, but AR (androgen receptor) has not been studied in human airways.Objectives: To measure whether AR and its ligands are associated with human asthma outcomes.Methods: We compared the effects of AR expression on lung function, symptom scores, and fractional exhaled nitric oxide (FeNO) in adults enrolled in SARP (Severe Asthma Research Program). The impact of sex and of androgens on asthma outcomes was also evaluated in the SARP with validation studies in the Cleveland Clinic Health System and the NHANES (U.S. National Health and Nutrition Examination Survey).Measurements and Main Results: In SARP (n = 128), AR gene expression from bronchoscopic epithelial brushings was positively associated with both FEV1/FVC ratio (R2 = 0.135, P = 0.0002) and the total Asthma Quality of Life Questionnaire score (R2 = 0.056, P = 0.016) and was negatively associated with FeNO (R2 = 0.178, P = 9.8 × 10-6) and NOS2 (nitric oxide synthase gene) expression (R2 = 0.281, P = 1.2 × 10-10). In SARP (n = 1,659), the Cleveland Clinic Health System (n = 32,527), and the NHANES (n = 2,629), women had more asthma exacerbations and emergency department visits than men. The levels of the AR ligand precursor dehydroepiandrosterone sulfate correlated positively with the FEV1 in both women and men.Conclusions: Higher bronchial AR expression and higher androgen levels are associated with better lung function, fewer symptoms, and a lower FeNO in human asthma. The role of androgens should be considered in asthma management.
Inhibition of calcium influx in isolated adult rat heart cells by ATP depletion.
Authors: R AHaworth, A BGoknur, D RHunter, J OHegge, H ABerkoff
Journal: Circulation Research (1987)

Using 45Ca, indo1, and quin2, calcium uptake was measured in isolated quiescent adult rat heart cells under different metabolic conditions. Exposure of cells in a medium containing 1 mM CaCl2 to rotenone and uncoupler resulted in adenosine triphosphate (ATP) depletion from 17.08 +/- 2.26 to 0.63 +/- 0.11 nmol/mg within 8 minutes, and the cells went into contracture. In this time, the cells lost 1.65 +/- 0.1 nmol Ca/mg of total rapidly exchangeable cellular calcium, and the level of free cytosolic calcium as measured by indo1 rose from 47.4 +/- 16.3 nM to 79.8 +/- 27.6 nM. The subsequent rate of rise of intracellular free calcium concentration was just 4 nM/min for at least 40 minutes. Therefore, we investigated the effect of ATP depletion on the rate of calcium entry. In cells loaded with sodium by ouabain treatment without calcium, the initial rate of calcium influx on calcium addition was inhibited by 82-84% when cellular ATP was depleted, as measured by 45Ca or indo1. Quin2 also showed a strong inhibit...
Effects of flecainide on ectopic atrial automaticity and conduction.
Authors: J RWindle, R CWitt, G JRozanski
Journal: Circulation (1993)

BACKGROUNDPrevious studies have shown that class Ic antiarrhythmic agents are effective in suppressing ectopic atrial rhythms and accessory pathway conduction.METHODS AND RESULTSTo explore the potential mechanisms for their effectiveness, we investigated the concentration-dependent effects of the Ic agent flecainide acetate (0.5 to 10 micrograms/mL) on atrial ectopic automaticity and exit conduction in isolated rabbit tricuspid valves. This experimental model consists of three major cell types as defined anatomically and by intracellular recordings: pacemaker, transitional, and working atrial muscle. Simultaneous recordings from these cell types before and during flecainide superfusion (n = 7) showed that the drug produced a slight, concentration-dependent slowing of pacemaker-transitional conduction but elicited third-degree transitional-working atrial muscle block in six of seven preparations at 10 micrograms/mL. Flecainide caused a significant dose-dependent reduction in the initial phase of diastolic ...
Wide-Field Endoscopic Submucosal Dissection for Whole-Antral and Whole-Incisura Gastric Multifocal Dysplasia
Authors: G Mavrogenis, F Bazerbachi, I Tsevgas, D Zachariadis
Journal: Endoscopy (2021)

Gastric endoscopic submucosal dissection (ESD) is applied for early gastric cancer (< 3 cm) or isolated visible lesions with dysplasia. In this video-report, we present two cases of whole-antral and whole-incisura ESD application for diffuse enteric metaplasia with multifocal dysplasia. Despite the necessity for technical expertise, this technique can be facilitated by the application of ancillary techniques, such as dynamic multifocal traction and countertraction, as previously described by our team. En-bloc resection offers obvious advantages in terms of decreasing recurrence risk, and obviating repeat interventions.
Effect of Applying the 2020 ESGE Post-Polypectomy Surveillance Guidelines on the Surveillance Recommendations: Study on A Population-Based CRC Screening Program
Authors: M Bustamante-Balén, M García-Campos, N Alonso, VL Zúñiga, C Sanchez, L Argüello, V Pons-Beltrán
Journal: Endoscopy (2021)

Aims Post-polypectomy surveillance is one of the most frequent indications for a colonoscopy, representing a heavy burden for endoscopy units. Our aim was to compare the surveillance intervals recommended by the recent ESGE 2020 guidelines with the ones recommended by the ESGE 2013 and the USMUSTF 2019 guidelines in our CRC screening population.
Phenotype-related alteration in expression of natriuretic peptide receptors in aortic smooth muscle cells.
Authors: SSuga, KNakao, IKishimoto, KHosoda, MMukoyama, HArai, GShirakami, YOgawa, YKomatsu, ONakagawa
Journal: Circulation Research (1992)

To elucidate the physiological and pathophysiological roles of the natriuretic peptide family in vascular smooth muscle cells, in which the natriuretic peptide family is implicated in growth inhibition as well as vasorelaxation, we have examined the phenotype-related expression of three kinds of natriuretic peptide receptors in rat aortic smooth muscle cells. The expression of natriuretic peptide receptors at the mRNA level was studied by Northern blot hybridization, and the expression at the protein level was determined by the cGMP production method and receptor binding assay. In intact aortic media, atrial natriuretic peptide (ANP)-A receptor mRNA and ANP-B receptor mRNA were detected, and the potency of cGMP production by ANP was at least two orders of magnitude stronger than that by C-type natriuretic peptide. Clearance receptor mRNA was undetectable, and only a small amount of the clearance receptor was detected by the binding assay in intact aortic media. By contrast, in cultured aortic smooth muscl...
Responses of the heart to stimulation of aortic body chemoreceptors in dogs.
Authors: FKarim, RHainsworth, O ASofola, L MWood
Journal: Circulation Research (1980)

We stimulated the aortic chemoreceptors in dogs that were anesthetized with chloralose and artificially ventilated by perfusing the isolated aortic arch with venous blood. Inotropic responses were determined by measuring the maximum rate of change of left ventricular pressure (dP/dt max) with aortic pressure and heart rate held constant. Stimulation of the aortic chemoreceptors resulted in an average increase in heart rate of 14 +/- 2.0 beats/min (mean +/- SE) from 166 +/- 7.7 beats/min and an increase in dP/dt max of 501 +/- 85 mm Hg/sec from 3508 +/- 154 mm Hg/sec. These changes were statistically significant (P less than 0.001). The afferent pathway of the reflex was shown to be in the vagus nerves and the efferent pathway in the cardiac sympathetic nerves. In some of the dogs, the carotid chemoreceptors were also stimulated. This resulted in decreases in heart rate and dP/dt max of 48 +/- 24 beats/min and 795 +/- 142 mm Hg/sec. Thus we have shown that stimulation of aortic chemoreceptors evokes chrono...
Presenting pulse pressure predicts thrombolytic therapy-related intracranial hemorrhage. Thrombolytic Predictive Instrument (TPI) Project results.
Authors: H PSelker, J RBeshansky, C HSchmid, J LGriffith, W TLongstreth, C MO'Connor, L RCaplan, E WMassey, R BD'Agostino, M MLaks
Journal: Circulation (1994)

BACKGROUNDIn selecting patients with acute myocardial infarction for thrombolytic therapy, it is important to identify patients who are at high risk for intracranial hemorrhage, for whom thrombolytic therapy is ill advised. We hypothesized that presenting pulse blood pressure, representing the hammer effect on cerebral vessels and the effects of age on arterial compliance, might predict thrombolysis-related intracranial hemorrhage better than systolic, diastolic, or mean arterial blood pressures.METHODS AND RESULTSOf 3483 Thrombolytic Predictive Instrument (TPI) Project subjects receiving thrombolytic therapy for acute infarction, we identified and obtained detailed clinical data on the 19 with treatment-related intracranial hemorrhages confirmed by computed tomography and on 175 matched controls. Systolic, diastolic, mean arterial, and pulse blood pressures were each significantly related to the occurrence of intracranial hemorrhage, with pulse pressure most highly related. The mean pulse pressure in p...
Role of the prostaglandin in norepinephrine release during augmented renal sympathetic nerve activity in the dog.
Authors: J AOliver, R RSciacca, JPinto, P JCannon
Journal: Circulation Research (1981)

To determine the role of the prostaglandins on renal norepinephrine release, the effect of inhibition of prostaglandin synthesis was examined in anesthetized dogs during reflex activation of the renal adrenergic nerves. Hypotension increased the renal vein plasma concentrations of norepinephrine from 380 +/- 59 to 608 +/- 106 pg/ml (mean +/- SEM; P less than 0.01) and of PGE2 from 55 +/- 7 to 81 +/- 41 pg/ml (P less than 0.05). Subsequent administration of indomethacin or meclofenamate lowered the renal venous concentration of PGE2 to 26 +/- 3 pg/ml (P less than 0.01), had no significant effect on the norepinephrine concentration (620 +/- 89 pg/ml). Administration of indomethacin or meclofenamate to dogs with sodium depletion lowered renal venin plasma concentration of PGE2 from 108 +/- 40 to 20 +/- 3 pg/ml (0.05 less than P less than 0.1) but had no effect on the renal venous norepinephrine concentration (475 +/- 50 vs. 397 +/- 46 pg/ml). In dogs fed a normal salt diet, inflation of a balloon placed in t...
Passage of ions and dextran molecules across the rete mirabile of the eel. The effects of charge.
Authors: E ARasio, C AGoresky
Journal: Circulation Research (1985)

The countercurrent-perfused rete mirabile of the eel is a preparation in which capillary permeability values can be determined accurately in broadscale fashion. To provide insight into charge effects on transendothelial passage, the permeability values of small inorganic cations (labeled sodium and rubidium, and stable potassium) and anions (labeled chloride, iodide, sulfate, and ferrocyanide) were compared to those expected for neutral solutes with approximately matched diffusion coefficients, and that of a neutral dextran fraction was compared to that of a negatively charged dextran sulfate with a similar diffusion coefficient. In the small ion experiments, the labeled iodide values were unexpectedly high, apparently due to the contamination of the labeled iodide solution with I-3. The permeabilities of the rest of the ions clustered at a level about 0.5 of the values which would have been expected for neutral solutes with similar diffusion coefficients. The decrement was interpreted to reflect the pres...
Relation between reversal of diastolic creep and recovery of systolic function after ischemic myocardial injury in conscious dogs.
Authors: D DGlower, JSchaper, J SKabas, H MHoffmeister, WSchaper, J ASpratt, J WDavis, J SRankin
Journal: Circulation Research (1987)

Although prolonged functional abnormalities after transient myocardial ischemia have been well described, the interrelationship between postischemic systolic and diastolic alterations remains controversial. Therefore, 24 chronically instrumented conscious dogs were studied with left ventricular and pleural micromanometers, ultrasonic dimension transducers in the left anterior descending (LAD) coronary distribution, and vena caval and coronary artery occluders. The LAD was occluded for 15 minutes and reperfused for 24 hours while vena caval occlusions were performed at intervals to measure myocardial segment length at 0 mm Hg transmural diastolic left ventricular pressure (L0). Coronary occlusion produced an immediate fall in systolic function as assessed by ejection shortening and stroke work and also induced a 16 +/- 4% increase in L0, which was termed diastolic creep. Throughout reperfusion, reversal of diastolic abnormalities correlated strongly with recovery of segmental shortening and stroke work (p ...
Eosinophils from hypereosinophilic patients damage endocardium of isolated feline heart muscle preparations.
Authors: A MShah, D LBrutsaert, A LMeulemans, L JAndries, MCapron
Journal: Circulation (1990)

Persistent eosinophilia in humans is often associated with endocardial damage to the heart, but a causal relation has not been established. We investigated the effect of eosinophils and eosinophil supernatants obtained from eight hypereosinophilic patients on the contractile performance and endocardial morphology of isolated, electrically stimulated cat papillary muscle preparations (n = 16). All these eosinophil suspensions contained high proportions of hypodense or activated cells. Eosinophils (5-15 x 10(6) ml organ bath) or eosinophil culture supernatants (prepared by overnight incubation at 37 degrees C) when added to papillary muscles produced acute changes in contractile behavior of these muscles identical to the previously reported effects of selective endocardial damage: a reduction in time to peak isometric twitch tension causing a reduction in peak isometric tension but with no significant reduction in rate of tension development or in maximum unloaded shortening velocity. All of these muscl...
Echocardiographic evaluation of long-term effects of exercise on left ventricular hypertrophy and function in professional bicyclists.
Authors: TNishimura, YYamada, CKawai
Journal: Circulation (1980)

Echocardiographic examinations were performed in 60 professional bicyclists and control subjects to determine the effects of exercise on left ventricular hypertrophy and function. The athletes were separated by age into three groups: group 1 (n = 14), 20-29 years; group 2 (n = 17), 30-39 years; and group 3 (n = 29), 40-49 years. Echocardiograms showed enlargment of the left ventricular end-diastolic dimensions in all three groups compared with age-matched control groups (p less than 0.001). Thickness of the interventricular septum and the left ventricular posterior wall was more prominent in group 3 of the athletes than groups 1 and 2 of the athletes and control group (p less than 0.001). Resting left ventricular function evaluated with fractional shortening, ejection fraction and mean velocity of circumferential fiber shortening was significantly depressed in group 3 compared with the other groups. Moreover, 14% of group 3 subjects showed enlargement of left atrial dimension and T-wave inversion in the l...
Catheter-mediated electrical ablation of the posterior septum via the coronary sinus: electrophysiologic and histologic observations in dogs.
Authors: FColtorti, G HBardy, DReichenbach, H LGreene, RThomas, D GBreazeale, CAlferness, T DIvey
Journal: Circulation (1985)

In a series of 12 dogs, the electrophysiologic and histologic effects of a single damped sine-wave shock delivered via standard electrocatheters to the region of the coronary sinus orifice were investigated. Six dogs received 200 J and six received 360 J of stored energy. The shock was delivered to two consecutive proximal poles of a standard quadripolar catheter positioned at the coronary sinus orifice and connected to the positive output (anode) of a defibrillator. A disc electrode positioned on the anterior chest wall served as the cathode (negative pole). During the shock, voltage and current were recorded. Electrophysiologic testing was done before and 4 weeks after the shock. At 4 weeks, animals were killed and serial sections of the atrioventricular groove and conduction system were performed. No significant long-term change in atrioventricular conduction, spontaneous or induced atrial or ventricular arrhythmias was observed. However, transient atrioventricular block was seen in five and idioventri...
Abstract 18852: Benefit of Using Proximal Anastomosis Assist Device in Coronary Artery Bypass Grafting for 3-vessel Disease
Authors: Aya Saito, Hiroaki Miyata, Minoru Ono, Noboru Motomura
Journal: Circulation (2017)

Introduction: Anastomosis assist device ('Device') use during coronary artery bypass grafting is thought to be less invasive to the ascending aorta than conventional side-biting clamp ('SBC') use a...
In vivo quantitative ultrasonic evaluation of myocardial fibrosis in humans.
Authors: EPicano, GPelosi, MMarzilli, FLattanzi, ABenassi, LLandini, AL'Abbate
Journal: Circulation (1990)

The aim of this study was to assess in vivo whether the regional ultrasonic reflectivity, evaluated by a real-time integrated backscatter analysis, was related to the local content of connective tissue in human myocardium as estimated by quantitative histology of endomyocardial biopsies. Sixteen patients with presumptive diagnosis of cardiomyopathy were ultrasonically studied by means of an M-mode-based echocardiographic system with quantitative integrated backscatter analysis capabilities. A 2.25-MHz transducer was used. The integrated value of the rectified radiofrequency signal of the interventricular septum was taken as integrated backscatter index and expressed in percent normalized for the pericardial interface (assumed to be 100%). All patients also underwent multiple left ventricular endomyocardial biopsies, which were stained with Masson's trichrome and studied with the use of a computer-assisted image analysis system. The percent integrated backscatter index was significantly higher in the prese...
Hemodynamic evaluation before and after closure of fenestrated Fontan. An acute study of changes in oxygen delivery.
Authors: Z MHijazi, J TFahey, C SKleinman, G SKopf, W EHellenbrand
Journal: Circulation (1992)

BACKGROUNDAcute changes in hemodynamics and oxygen delivery accompanying temporary occlusion of atrial defects in 14 patients after a fenestrated Fontan procedure were evaluated at a median interval of 32 days after surgery to identify candidates for permanent transcatheter closure of their defects.METHODS AND RESULTSPatients ranged in age from 9 months to 33 years and in weight from 7.9 to 69 kg. Right atrial (RA), left atrial (LA), and aortic pressures, mixed venous (SmvO2) and aortic (SaO2) oxygen saturation, and whole-body oxygen consumption (VO2) were measured, and systemic blood flow (Qs), systemic oxygen transport (SOT), and oxygen extraction were calculated before and after occlusion. SmvO2, VO2, and RA pressures did not change, but SaO2 increased from 84 +/- 6% to 95 +/- 3% (p less than 0.05), and LA pressures fell from 5.1 +/- 3.6 to 3.7 +/- 2.2 mm Hg (p less than 0.05). Qs fell from 2.4 +/- 0.7 to 1.8 +/- 0.41.min-1.m-2 (p less than 0.05), SOT fell from 425 +/- 154 to 366 +/- 112 ml.O2.min-1.m-...
Stretch-induced arrhythmias in the isolated canine ventricle. Evidence for the importance of mechanoelectrical feedback.
Authors: D EHansen, C SCraig, L MHondeghem
Journal: Circulation (1990)

Alterations in loading conditions and muscle length influence the electrophysiology of ventricular myocardium and may play a role in arrhythmogenesis in globally dilated or dyskinetic ventricles. To test the hypothesis that stretch can initiate arrhythmias in normal myocardium, the response to graded mechanical stretch was studied in seven isolated blood-perfused canine ventricles. After eight conditioning contractions produced by His bundle pacing (2 Hz), global stretch of the ventricle was produced by a servocontrolled pump that abruptly increased ventricular volume by a precise amount (delta V) during early diastole and then returned ventricular volume to the initial holding volume (Vi). Ventricular premature contractions were readily produced; ventricular couplets and short runs of ventricular tachycardia were occasionally elicited. The probability of a stretch-induced arrhythmia was determined from multiple alternating sequences in which a stretch of known amplitude (delta V) or no stretch was delive...