tbuckley/cabot-search huggingface dataset:
Biocompatible reduced graphene oxide stimulated BMSCs induce acceleration of bone remodeling and orthodontic tooth movement through promotion on osteoclastogenesis and angiogenesis
Authors: Delong Jiao, Jing Wang, Wenting Yu, Ke Zhang, Ning Zhang, Lingyan Cao, Xinquan Jiang, Yuxing Bai
Journal: Bioactive Materials (2022)

We has synthesized the biocompatible gelatin reduced graphene oxide (GOG) in previous research, and in this study we would further evaluate its effects on bone remodeling in the aspects of osteoclastogenesis and angiogenesis so as to verify its impact on accelerating orthodontic tooth movement. The mouse orthodontic tooth movement (OTM) model tests in vivo showed that the tooth movement was accelerated in the GOG local injection group with more osteoclastic bone resorption and neovascularization compared with the PBS injection group. The analysis on the degradation of GOG in bone marrow stromal stem cells (BMSCs) illustrated its good biocompatibility in vitro and the accumulation of GOG in spleen after local injection of GOG around the teeth in OTM model in vivo also didn't influence the survival and life of animals. The co-culture of BMSCs with hematopoietic stem cells (HSCs) or human umbilical vein endothelial cells (HUVECs) in transwell chamber systems were constructed to test the effects of GOG stimulated BMSCs on osteoclastogenesis and angiogenesis in vitro. With the GOG stimulated BMSCs co-culture in upper chamber of transwell, the HSCs in lower chamber manifested the enhanced osteoclastogenesis. Meanwhile, the co-culture of GOG stimulated BMSCs with HUVECs showed a promotive effect on the angiogenic ability of HUVECs. The mechanism analysis on the biofunctions of the GOG stimulated BMSCs illustrated the important regulatory effects of PERK pathway on osteoclastogenesis and angiogenesis. All the results showed the biosecurity of GOG and the biological functions of GOG stimulated BMSCs in accelerating bone remodeling and tooth movement.
Confirmation of endotypes based on levels of eosinophil, mast cell and basophil microparticles in nasal lavage fluids in chronic rhinosinusitis with nasal polyps using two Northwestern Memorial Hospital cohorts
Authors: Toru Takahashi, Lydia Suh, Roderick Carter, Kris Erickson, Julia Huang, James Norton, Atsushi Kato, Sergejs Berdnikovs, Whitney Stevens, Anju Peters, Leslie Grammer, Stephanie Shintani Smith, Bruce Tan, David Conley, Kevin Welch, Robert Kern, Robert Schleimer
Journal: Journal of Allergy and Clinical Immunology (2022)
The Diseases of Society (The Vice and Crime Problem).
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>Recherches Cliniques et Thérapeutiques sur L'Epilepsie, L'Hystérie, L'Idiotie et L'Hydrocéphalie</i>.—Compte Rendu du Service des Enfants Idiots, Epileptiques et Arrières de Bicètre pendant l'annèe 1893. Par Bourneville, Médecin de Bicètre. Avec la collaboration de M.M. Boncourt, Cornet, Lenoir, Jules Noir, et P. Sollier. Vol. XIV. Avec 89 figures dans le texte et un planche, Paris, 1894
Journal: American Journal of Psychiatry (1894)
Air Pollution Could Be An Insignificant Problem
Journal: JAMA (1964)

Modern technology has made it possible to control air pollution "to the point where it is no longer a significant problem," the Los Angeles County air pollution control officer told participants in the American Medical Association Congress on Environmental Health Problems, May 1-2 in Chicago. S. Smith Griswold said that use of all available techniques of reducing the pollutants in automobile exhausts, combined with a large-scale control program for industries, can make any city with a pollution problem more healthy and more comfortable for its residents. "Ignorance and apathy are the real limitations upon the control of air pollution," Griswold said. "A community endures air pollution because it lacks leadership and the will to act." He commented that the most frequent objection to air pollution control programs is the expense. "Spokesmen for industry have standard objections such as, 'Our industry can't afford such investments in nonproductive equipment,' or 'We won't
New ‘Antigens’ in Membranous Nephropathy
Authors: Sanjeev Sethi
Journal: Journal of the American Society of Nephrology (2020)

Membranous nephropathy (MN) occurs due to deposition of immune complexes along the subepithelial region of glomerular basement membrane. Two previously identified target antigens for the immune complexes, PLA2R (identified in 2009) and THSD7A (in 2014), account for approximately 60% of all MN, both primary and secondary. In the remaining MN, target antigens were unknown. Use of laser microdissection and mass spectrometry enabled identification of new “antigens.” This approach led to the identification of four novel types of MN: exotosin 1 (EXT1)– and exotosin 2 (EXT2)–associated MN, NELL1-associated MN, Sema3B-associated MN, and PCDH7-associated MN. Each of these represents a distinct disease entity, with different clinical and pathologic findings. In this review, the structure of the proteins and the clinical and pathologic findings of the new types of MN are discussed. The role of mass spectrometry for accurate diagnosis of MN cannot be overemphasized. Finally, any classification of MN should be made on the basis of the antigens that are detected. Further studies are required to understand the pathophysiology, response to treatment, and outcomes of these new MNs.
Fasciculation
Authors: Samuel J. Belfer
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
P113: INCIDENCE OF HAEMOGLOBINOPATHY IN SLOVAKIA
Authors: V Fabryova, A Vasiľová, A Kollárová, K Gbúrová, B Fabry
Journal: HemaSphere (2022)

Background: The paper presents results of 27- year epidemiological study of screening and follow-up haemoglobinopathies in Slovakia. Aims: The incidence of haemoglobinopathies in Slovek Republic Methods: Between 1993 – 2020, in two centres in Bratislava and in one centre in Kosice, carriers of beta-thalassaemic genes or other haemoglobinopathies were searched for. Patients with a probability of having a haemoglobinopathy were sent to the research facilities. Diagnosis was performed by haematologists, whereby the family history was evaluated, together with overall clinical condition, blood count and blood smear, iron and haemolysis parameters, mutations of hereditary haemochromatosis, and haemoglobin electrophoresis testing. Results: A clinical suspicion of the heterozygous form of beta-thalassaemia or other haemoglobinopathies was documented in 694 patients. Of them 25 (6.04%) patients were foreigners. 415 (59.85%) patients were genetically examined. In 385 (92.99%) of them heterozygote beta-thalassaemia was confirmed (in 98 families). Five patients (1.21%) were diagnosed for delta,beta-thalassaemia, 4 patients (0,97%) for delta,beta-gama1-thalasaemia or persistent hereditary fetal haemoglobin. In total we diagnosed 20 mutations of beta-globin gene. The most frequent mutations were IVS 1.110 (G-A), IVS II-1(G-A) and codon 39. Evidence of haemoglobin S (heterozygote sickle cell anaemia) was also notable in two non-relative children, whose fathers were of African origin, in one patient of Ghana and in one patient from Nigeria. One female patient was followed up for haemoglobin Santa Ana (mutation de novo), one family for haemoglobin Bishopstown and one patient for mutation KLF1 gene. In our group were 14 patients (3.14%) diagnosed for alpha-thalassaemia. All patients were heterozygotes, only one female patient from Macedonia was a double heterozygote for beta-thalasaemie. Clinicaly all of the patients had a minor or intermedia form. In the years of 2012–2019 we observed 12 pregnant patients with beta-thalasaemie. One of them had multiple pregnancies, all deliveries were without haematological complications. Conclusions: The study showed that in the west and eastern Slovakia there is a higher number for thalassaemia and other haemoglobinopathies. Mutations are of historical origin or over the past years we have recorded an increase number of mutations from areas with high incidence of haemoglobinopathies. It is necessary to continue in search of pathological gene carriers to avoid serious forms of the disease. Key words: thalassaemia – sickle cell disease – prevention- epidemiological study – Slovakia References 1. Divoka et al, Hemoglobin 2016;40:156–162 2. Engert et al, Haematologica 2016;101:115–208 3. Fabryova et al, Centr Eur J Public Health 2017;25:67–71 4. Pinto et al, Internal and emergency medicine 2019;7:1051–64 5. Fabryova et al, J Hematol Transf 2020;7(1):1086 6. Vieves Corrons et al, Acta Biomed 2020;91:2
Myosteatosis, but not Sarcopenia, Predisposes NAFLD Subjects to Early Steatohepatitis and Fibrosis Progression
Authors: Yun-Cheng Hsieh, Sae Kyung Joo, Bo Kyung Koo, Han-Chieh Lin, Dong Hyeon Lee, Mee Soo Chang, Jeong Hwan Park, Young Ho So, Won Kim
Journal: Clinical Gastroenterology and Hepatology (2022)
Cannabis‐related allergies: An international overview and consensus recommendations
Authors: Isabel J. Skypala, Samira Jeimy, Hannelore Brucker, Ajay P. Nayak, Ine I. Decuyper, Jonathan A. Bernstein, Lori Connors, Amin Kanani, Ludger Klimek, Shun Chi Ryan Lo, Kevin R. Murphy, Anil Nanda, Jill. A. Poole, Jolanta Walusiak‐Skorupa, Gordon Sussman, Joanna S. Zeiger, Richard E. Goodman, Anne K. Ellis, William S. Silvers, Didier G. Ebo
Journal: Allergy (2022)

Cannabis is the most widely used recreational drug in the world. Cannabis sativa and Cannabis indica have been selectively bred to develop their psychoactive properties. The increasing use in many countries has been accelerated by the COVID-19 pandemic. Cannabis can provoke both type 1 and type 4 allergic reactions. Officially recognized allergens include a pathogenesis-related class 10 allergen, profilin, and a nonspecific lipid transfer protein. Other allergens may also be relevant, and recognition of allergens may vary between countries and continents. Cannabis also has the potential to provoke allergic cross-reactions to plant foods. Since cannabis is an illegal substance in many countries, research has been hampered, leading to challenges in diagnosis since no commercial extracts are available for testing. Even in countries such as Canada, where cannabis is legalized, diagnosis may rely solely on the purchase of cannabis for prick-to-prick skin tests. Management consists of avoidance, with legal issues hindering the development of other treatments such as immunotherapy. Education of healthcare professionals is similarly lacking. This review aimed to summarize the current status of cannabis allergy and proposes recommendations for the future management of this global issue.
Regulation of Tumor Invasion by the Physical Microenvironment: Lessons from Breast and Brain Cancer
Authors: Garrett F. Beeghly, Kwasi Y. Amofa, Claudia Fischbach, Sanjay Kumar
Journal: Annual Review of Biomedical Engineering (2022)

The success of anticancer therapies is often limited by heterogeneity within and between tumors. While much attention has been devoted to understanding the intrinsic molecular diversity of tumor cells, the surrounding tissue microenvironment is also highly complex and coevolves with tumor cells to drive clinical outcomes. Here, we propose that diverse types of solid tumors share common physical motifs that change in time and space, serving as universal regulators of malignancy. We use breast cancer and glioblastoma as instructive examples and highlight how invasion in both diseases is driven by the appropriation of structural guidance cues, contact-dependent heterotypic interactions with stromal cells, and elevated interstitial fluid pressure and flow. We discuss how engineering strategies show increasing value for measuring and modeling these physical propertiesfor mechanistic studies. Moreover, engineered systems offer great promise for developing and testing novel therapies that improve patient prognosis by normalizing the physical tumor microenvironment.
Evaluating the Findings of the IMPACT-C Randomized Clinical Trial to Improve COVID-19 Vaccine Coverage in Skilled Nursing Facilities
Authors: Sarah D. Berry, Keith S. Goldfeld, Kevin McConeghy, David Gifford, H. Edward Davidson, Lisa Han, Maggie Syme, Ashvin Gandhi, Susan L. Mitchell, Jill Harrison, Amy Recker, Kimberly S. Johnson, Stefan Gravenstein, Vincent Mor
Journal: JAMA Internal Medicine (2022)

Identifying successful strategies to increase COVID-19 vaccination among skilled nursing facility (SNF) residents and staff is integral to preventing future outbreaks in a continually overwhelmed system. To determine whether a multicomponent vaccine campaign would increase vaccine rates among SNF residents and staff. This was a cluster randomized trial with a rapid timeline (December 2020-March 2021) coinciding with the Pharmacy Partnership Program (PPP). It included 133 SNFs in 4 health care systems across 16 states: 63 and 70 facilities in the intervention and control arms, respectively, and participants included 7496 long-stay residents (>100 days) and 17 963 staff. Multicomponent interventions were introduced at the facility level that included: (1) educational material and electronic messaging for staff; (2) town hall meetings with frontline staff (nurses, nurse aides, dietary, housekeeping); (3) messaging from community leaders; (4) gifts (eg, T-shirts) with socially concerned messaging; (5) use of a specialist to facilitate consent with residents' proxies; and (6) funds for additional COVID-19 testing of staff/residents. The primary outcomes of this study were the proportion of residents (from electronic medical records) and staff (from facility logs) who received a COVID-19 vaccine (any), examined as 2 separate outcomes. Mixed-effects generalized linear models with a binomial distribution were used to compare outcomes between arms, using intent-to-treat approach. Race was examined as an effect modifier in the resident outcome model. Most facilities were for-profit (95; 71.4%), and 1973 (26.3%) of residents were Black. Among residents, 82.5% (95% CI, 81.2%-83.7%) were vaccinated in the intervention arm, compared with 79.8% (95% CI, 78.5%-81.0%) in the usual care arm (marginal difference 0.8%; 95% CI, -1.9% to 3.7%). Among staff, 49.5% (95% CI, 48.4%-50.6%) were vaccinated in the intervention arm, compared with 47.9% (95% CI, 46.9%-48.9%) in usual care arm (marginal difference: -0.4%; 95% CI, -4.2% to 3.1%). There was no association of race with the outcome among residents. A multicomponent vaccine campaign did not have a significant effect on vaccination rates among SNF residents or staff. Among residents, vaccination rates were high. However, half the staff remained unvaccinated despite these efforts. Vaccination campaigns to target SNF staff will likely need to use additional approaches. ClinicalTrials.gov Identifier: NCT04732819.
Medical Missionary Work in China.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sofosbuvir‐velpatasvir‐voxilaprevir in adolescents 12 to 17 years old with HCV infection
Authors: Guiseppe Indolfi, Deirdre Kelly, Gabriella Nebbia, Raffaele Iorio, Anna Mania, Vania Giacomet, Leszek Szenborn, Jiang Shao, Mun Sang Yue, Chia‐Hsiang Hsueh, Bandita Parhy, Kathryn Kersey, Alessandra Mangia, Malgorzata Pawlowska, Sanjay Bansal
Journal: Hepatology (2022)

Abstract Background and Aims Sofosbuvir‐velpatasvir‐voxilaprevir is a pangenotypic regimen for chronic HCV infection. In the USA and Europe, sofosbuvir‐velpatasvir‐voxilaprevir once daily for 12 weeks is indicated for adults who previously received an HCV NS5A inhibitor. In Europe, sofosbuvir‐velpatasvir‐voxilaprevir is also indicated in the absence of prior HCV direct‐acting antiviral (DAA) therapy as an 8‐week or 12‐week regimen. In an open‐label study, we evaluated the safety, efficacy, and pharmacokinetics of sofosbuvir‐velpatasvir‐voxilaprevir in adolescents 12 to 17 years with chronic HCV of any genotype. Methods In this Phase 2, multicenter study, sofosbuvir‐velpatasvir‐voxilaprevir 400/100/100 mg daily was administered to adolescents for 8 weeks if DAA‐naïve or for 12 weeks for cirrhosis or prior DAA failure. The key efficacy endpoint was sustained virologic response 12 weeks after therapy (SVR12). Intensive pharmacokinetic sampling was done in 14 patients at week 2 or 4, and samples for population pharmacokinetics were collected in all patients. Results All patients ( n = 21) were naïve to HCV DAAs, and none had cirrhosis. HCV genotype 3a infection was most common, occurring in 43% of patients. Overall, 100% of patients (21 of 21) reached SVR12. The most common adverse events were abdominal pain and headache (24% each) and nausea (19%); no adverse events led to discontinuation. The only serious adverse event, hypotension, was considered related to study drug and resolved the same day without interruption of treatment. Sofosbuvir‐velpatasvir‐voxilaprevir exposures were similar to those observed in adults. Conclusions The pangenotypic regimen of sofosbuvir‐velpatasvir‐voxilaprevir is highly efficacious and well‐tolerated in treating chronic HCV infection in adolescents.
The crosstalk between reactive oxygen species and noncoding RNAs: from cancer code to drug role
Authors: Jing Zuo, Zhe Zhang, Maomao Li, Yun Yang, Bohao Zheng, Ping Wang, Canhua Huang, Shengtao Zhou
Journal: Molecular Cancer (2022)

Abstract Oxidative stress (OS), characterized by the excessive accumulation of reactive oxygen species (ROS), is an emerging hallmark of cancer. Tumorigenesis and development driven by ROS require an aberrant redox homeostasis, that activates onco-signaling and avoids ROS-induced programmed death by orchestrating antioxidant systems. These processes are revealed to closely associate with noncoding RNAs (ncRNAs). On the basis of the available evidence, ncRNAs have been widely identified as multifarious modulators with the involvement of several key redox sensing pathways, such as NF-κB and Nrf2 signaling, therefore potentially becoming effective targets for cancer therapy. Furthermore, the vast majority of ncRNAs with property of easy detected in fluid samples (e.g., blood and urine) facilitate clinicians to monitor redox homeostasis, indicating a novel method for cancer diagnosis. Herein, focusing on carcinoma initiation, metastasis and chemoradiotherapy resistance, we aimed to discuss the ncRNAs-ROS network involved in cancer progression, and the potential clinical application as biomarkers and therapeutic targets.
Peptic Ulcer: Clinical Aspects, Diagnosis, Management
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal