POS1440 ASSOCIATION BETWEEN SERUM URATE AND INFLAMMATORY MARKERS IN YOUNG ADULTS: CROSS-SECTIONAL FINDINGS FROM A BIRTH COHORT
Authors: T. Loyola Correa, I. Oliveira de Oliveira
Journal: Annals of the Rheumatic Diseases (2021)

Background: Uric acid is the end product of purine metabolism and an abruptly increase or decrease on its serum concentrations can form free urate crystals and precipitate a gout attack. Serum urate (SU) has been positively and independently associated with cardiometabolic diseases in observational studies, but causal roles remain unclear. 1 In addition, inflammatory markers are deeply associated with cardiometabolic diseases, such as essential hypertension and type 2 diabetes mellitus. 2 However, little has been published about the association of SU and subclinical inflammation. Objectives: To assess the associations of SU with interleukin 6 (IL-6), C-reactive protein (CRP), and adiponectin at 22-year-old individuals belonging to the 1993 birth cohort of Pelotas (Brazil). Methods: During 1993, all live born babies in the city were invited to take part in a prospective study and sub-samples of this cohort were followed-up since then. At the 22-year follow-up, interviews and clinical measurements were performed and non-fasting blood samples were drawn from the participants. SU was evaluated by enzymatic-colorimetric assay; IL-6 and adiponectin, by immunoassay; and CRP by immunoturbidimetric assay. The co-variables taken into consideration were skin color; asset index at 22 years; cardiometabolic risk factors (body mass index, systolic and diastolic blood pressure); presence of cardiometabolic diseases (hypertension, diabetes and dyslipidemia); and behavioral variables (alcohol use disorder, smoking status and physical inactivity). Exposition variables were categorized into tertiles. Sex-stratified linear regressions have been performed using STATA 13 and p&lt;0.05 was considered statistically significant. Results: The sample was composed by 1657 (46.3%) men and 1921 (53.7%) women of 22 years old. The median (25-75 IQR) for IL-6 (pg/mL) was higher in women than in men [1.26 (0.85; 2.02) vs. 1.07 (0.76; 1.69)]; the same was observed for CRP (mg/dL) [1.6 (0.6; 4.1) vs. 0.6 (0.3; 1.4)]. The mean (95%CI) for adiponectin (μg/mL) was also higher in women [10.72 (10.50; 10.94) vs. 7.97 (7.78; 8.16)]. As expected, the mean (±SD) for SU (mg/dL) was higher in men (5.2±1.2 vs. 3.9±1.1). In adjusted analysis, IL-6 was positively associated with SU only in women; p=0.018 (Table 1). CRP was positively associated with SU in crude and adjusted analyses for both sexes; p=0.002 (Table 1). In addition, higher adiponectin was independently associated with lower concentrations of SU for men (p&lt;0.001) and women (p=0.013) (Table 1). Conclusion: The increase of SU is associated with IL-6 and CRP increasing and adiponectin decreasing since early adult age. References: [1]Mortada I. Curr Hypertens Rep. 2017;19(9):69. [2]Pouvreau C et al. J Inflamm Res. 2018;19(11):61-68. Table 1. Mean SU concentrations (mg/dL) according to physiological markers ’ tertiles Physiological marker Tertile Men Women Crude Adjusted Crude Adjusted Mean CI95% Mean CI95% Mean CI95% Mean CI95% p&lt;0.001 p=0.12 p&lt;0.001 p=0.018 IL-6 1 5.01 (4.91; 5.12) 5.16 (5.06; 5.26) 3.67 (3.58; 3.77) 3.85 (3.76; 3.95) 2 5.29 (5.19; 5.40) 5.30 (5.19; 5.40) 3.81 (3.72; 3.90) 3.88 (3.79; 3.97) 3 5.46 (5.35; 5.58) 5.30 (5.18; 5.42) 4.23 (4.14; 4.31) 4.03 (3.94; 4.12) p&lt;0.001 p=0.002 p&lt;0.001 p=0.002 CRP 1 5.01 (4.93; 5.09) 5.14 (5.05; 5.22) 3.57 (3.47; 3.66) 3.77 (3.67; 3.87) 2 5.37 (5.26; 5.47) 5.31 (5.20; 5.41) 3.89 (3.80; 3.98) 3.95 (3.86; 4.03) 3 5.62 (5.48; 5.75) 5.42 (5.28; 5.56) 4.13 (4.06; 4.20) 3.99 (3.92; 4.06) p&lt;0.001 p&lt;0.001 p&lt;0.001 p=0.013 Adiponectin 1 5.45 (5.37; 5.54) 5.36 (5.27; 5.45) 4.26 (4.16; 4.36) 4.06 (3.95; 4.16) 2 5.09 (4.99; 5.20) 5.19 (5.09; 5.30) 3.93 (3.84; 4.01) 3.91 (3.83; 3.99) 3 4.97 (4.84; 5.09) 5.07 (4.94; 5.19) 3.75 (3.67; 3.82) 3.86 (3.79; 3.93) Disclosure of Interests: None declared