tbuckley/cabot-search huggingface dataset:
EUS-Guided Tissue Acquisition Of GI Subepithelial Lesions With Macroscopic On-Site Evaluation (MOSE): Adequacy With FNA And FNB Needles
Authors: T Togliani, S Pilati
Journal: Endoscopy (2021)

Aims EUS imaging, even if coupled with FNA, has a suboptimal accuracy in diagnosing subepithelial lesions; to increase the performance of EUS-guided tissue acquisition the use of FNB needles, or the addition of macroscopic (MOSE) or microscopic (ROSE) evaluation of the specimen have been proposed. The aim of this study is to compare the adequacy of FNA with MOSE and FNB with MOSE in this setting.
Postural changes in diastolic blood pressure and the risk of myocardial infarction: the Normative Aging Study.
Authors: DSparrow, C PTifft, BRosner, S TWeiss
Journal: Circulation (1984)

To assess the relationship of postural changes in blood pressure to risk of myocardial infarction, 1359 men were followed for an average of 8.7 years. The men were participants in the Normative Aging Study, a longitudinal study of aging initiated in 1963 at the Veterans Administration Outpatient Clinic in Boston. It was found that the relationship of sitting blood pressure to the subsequent incidence of myocardial infarction was modified by a variable formed by subtracting supine from standing diastolic blood pressure (delta DBP). The effect of sitting diastolic blood pressure on risk of myocardial infarction was confined primarily to men with a delta DBP of 10 mm Hg or more. The effect of sitting systolic blood pressure on risk of myocardial infarction was apparent in all categories of delta DBP (less than 1, 1 to 9, greater than or equal to 10 mm Hg), but the gradient of risk became stronger with increasing levels of delta DBP. The modifying influence of delta DBP remained even when standard coronary ri...
The relation of localized myocardial warming to changes in cardiac surface electrograms in dogs.
Authors: M JBurgess, R LLux, R FWyatt, J AAbildskov
Journal: Circulation Research (1978)

We studied the relationship of the size and severity of alteration of recovery properties in localized areas to changes in cardiac surface electrograms in experiments on six open-chest dogs. Alterations in recovery properties were induced thermally because size and severity of the affected area could be controlled on the basis of physical principles which were modeled. We recorded unipolar electrograms from 75 cardiac surface sites simultaneously during stimulation of atria and pulmonary conus in control periods and in the presence of warmed areas of varying sizes and intensities. Size of the areas was controlled by the diameter of an aperture through which a light source was directed. Intensity was controlled by the light source excitation voltage. Myocardial temperature was monitored with a thermistor. The QRS, STT, and QRST deflection areas were determined by computer processing and displayed as isoarea maps. Difference maps also were determined by subtracting control QRST isoarea maps from those obtai...
Prospective Study of Type 1 and Type 2 Diabetes and Risk of Stroke Subtypes: the Nurses’ Health Study
Authors: Mohsen Janghorbani, Kathryne M. Rexrode, Giancarlo Logroscino
Journal: Diabetes Care (2007)

We thank Tuttolomondo et al. (1) for their interest in our study (2). In response, we would like to clarify several points. First, coding of strokes has been ongoing in the Nurses’ Health Study since 1976. We have not had funding to implement coding by TOAST (Trial of Org 10172 in Acute Stroke Treatment) classification (3) but hope to do so in the future. In an internal comparison of coding …
Modulation of Ca2+ release in cultured neonatal rat cardiac myocytes. Insight from subcellular release patterns revealed by confocal microscopy.
Authors: PLipp, ENiggli
Journal: Circulation Research (1994)

It is well established that in heart muscle the influx of Ca2+ through Ca2+ channels during the action potential is the main trigger for Ca2+ release from the sarcoplasmic reticulum (SR), but intact cardiac tissue and single myocytes are also known to exhibit spontaneous Ca2+ release from the SR under a variety of circumstances. Although conditions favoring spontaneous activity have been examined extensively, mechanisms modulating or regulating spontaneous as well as triggered Ca2+ release are still largely unknown. Using the high spatial and temporal resolution of laser-scanning confocal microscopy, we investigated subcellular aspects of spontaneous and triggered Ca2+ release in isolated rat neonatal myocytes loaded with the Ca(2+)-sensitive fluorescent dye fluo 3. Three distinct patterns of spontaneous Ca2+ release were identified: (1) a homogeneous Ca2+ release, presumably corresponding to Ca2+ release during a spontaneous action potential, (2) a focal or spatially restricted Ca2+ release with no or on...
Increased coronary mortality in relatives of hypercholesterolemic school children: the Muscatine study.
Authors: H GSchrott, W RClarke, D AWiebe, W EConnor, R MLauer
Journal: Circulation (1979)

From 2,874 school children participating in the 1971 and 1973 Muscatine Coronary Risk Factor Survey, we selected three groups of index cases for detailed family study: the HIGH group (n = 56), with cholesterol levels greater than the 95th percentile twice; the MIDDLE group (n = 46), cholesterol levels between the 5th and 95th percentile; and the LOW group (n = 46), cholesterol levels less than the 5th percentile twice. Coronary mortality determined from death certificates was increased in the young relatives (ages 30-59) of the HIGH group index cases, as follows: twofold excess in HIGH male relatives compared with the MIDDLE or LOW group (p less than 0.05); tenfold excess in the HIGH female relatives compared with the MIDDLE and LOW group combined (p less than 0.01). After correction for years at risk, there was an approximately twofold significantly-increased coronary mortality. Stroke mortality was higher, although not significantly, in the older relatives (ages greater than or equal to 60) of the HIGH ...
20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries.
Authors: Y HMa, DGebremedhin, M LSchwartzman, J RFalck, J EClark, B SMasters, D RHarder, R JRoman
Journal: Circulation Research (1993)

Recent studies have indicated that renal arteries can produce 20-hydroxyeicosatetraenoic acid (20-HETE) and suggest the potential involvement of a P450 metabolite of arachidonic acid in the myogenic activation of canine renal arteries. In the present study, the effects of 20-HETE on isolated canine renal arcuate arteries were studied. Administration of 20-HETE to the bath or the lumen at concentrations of 0.01-1 microM produced a graded reduction in the diameter of these vessels. In contrast, 19(R)-HETE was a vasodilator, whereas 19(S)-HETE was relatively inactive. The vasoconstrictor response to 20-HETE was not altered by the cyclooxygenase inhibitor indomethacin, endoperoxide/thromboxane receptor antagonist SQ29548, or combined blockade of the cyclooxygenase, lipoxygenase, and P450 pathways using indomethacin, baicalein, and 7-ethoxyresorufin. The response to 20-HETE was associated with depolarization and a sustained increase in the intracellular calcium concentration in renal vascular smooth muscle cel...
Results of coronary artery surgery in patients with poor left ventricular function (CASS).
Authors: E LAlderman, L DFisher, PLitwin, G CKaiser, W OMyers, CMaynard, FLevine, MSchloss
Journal: Circulation (1983)

We identified 420 medically treated and 231 surgically treated patients (coronary graft plus myocardial surgery in 30%) who had severe left ventricular dysfunction manifest by an ejection fraction below 0.36 and markedly abnormal wall motion. Compared with medically treated patients, those treated surgically had more severe angina (56.7% vs 29.0% class III or IV; p less than .001), less heart failure as predominant symptom (11.1% vs 18.8%; p less than .003), more severe coronary disease (66.7% vs 50.2% three-vessel disease; p less than .001), a greater concentration of left main coronary artery lesions greater than 70% (12.6% vs 3.8%: p less than .001), and a greater estimated extent of jeopardized myocardium (p less than .001). Multivariate regression analysis of survival, which adjusts for the above covariates, showed that surgical treatment prolonged survival (p less than .05), although it ranked below severity of heart failure symptoms, age, ejection fraction, and left main stenosis greater than 70% i...
A CASE OF GONORRHŒAL KERATOSIS
Authors: W. HERBERT BROWN, H. HARGREAVES
Journal: British Journal of Dermatology (1917)

Journal Article A CASE OF GONORRHŒAL KERATOSIS Get access W. HERBERT BROWN, M.D., R.A.M.C. Capt., W. HERBERT BROWN, M.D., R.A.M.C. Capt. Search for other works by this author on: Oxford Academic Google Scholar H. HARGREAVES, R.A.M.C. Capt. H. HARGREAVES, R.A.M.C. Capt. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 29, Issue 2, 1 April 1917, Pages 107–110, https://doi.org/10.1111/j.1365-2133.1917.tb09660.x Published: 01 April 1917
Prospective Evaluation of Complications After Endoscopic Mucosal Resection (EMR) of Superficial Non-Ampullary Duodenal Epithelial Tumors (Snadets)
Authors: M Amoyel, A Belle, M Dhooge, E Abou Ali, R Hallit, B Terris, S Leblanc, F Prat, R Coriat, S Chaussade, M Barret
Journal: Endoscopy (2021)

Aims SNADETs are rare lesions, with poorly standardized resection techniques. The complication rates after EMR range from 10.5 to 41.3 %. The aim of our work was to evaluate the efficacy and safety of EMR of non-ampullary duodenal adenomas.
Mechanism of cocaine-induced myocardial depression in dogs.
Authors: T DFraker, P NTemesy-Armos, P SBrewster, R DWilkerson
Journal: Circulation (1990)

Cocaine causes pronounced depression of left ventricular function in conscious dogs immediately after intravenous administration. To examine this effect, 14 mongrel dogs were anesthetized with pentobarbital sodium (32 mg/kg) and instrumented with arterial and venous catheters and a Doppler blood flow transducer on the left circumflex coronary artery. Two weeks later, heart rate, blood pressure, coronary blood flow, and regional left ventricular ejection fraction (by two-dimensional echocardiography) were measured before and 1, 2, 5, and 10 minutes after cocaine (4 mg/kg i.v.), while the animals were fully conscious. Heart rate, blood pressure, and coronary blood flow were increased significantly at each time after cocaine. Regional ejection fraction, however, was depressed by 50 +/- 7%, 35 +/- 4%, and 21 +/- 4% at 1, 2, and 5 minutes after cocaine treatment, respectively. Ten minutes after cocaine treatment, regional ejection fraction had recovered to a level not significantly different from baseline. Bec...
Improved clinical outcome in a randomized phase II study of anti-PD-1 camrelizumab plus decitabine in relapsed/refractory Hodgkin lymphoma
Authors: Yang Liu, Chunmeng Wang, Xiang Li, Liang Dong, Qingming Yang, Meixia Chen, Fengxia Shi, Malcolm Brock, Miao Liu, Qian Mei, Jiejie Liu, Jing Nie, Weidong Han
Journal: Journal for ImmunoTherapy of Cancer (2021)

Background Programmed death-1 (PD-1) blockade monotherapy induced durable remission in a subset of patients with relapsed/refractory classical Hodgkin lymphoma (cHL). We asked whether the anti-PD-1 agent, camrelizumab, combined with the DNA demethylating agent, decitabine, improves progression-free survival (PFS) in patients with relapsed/refractory cHL over camrelizumab alone. Methods This extended follow-up of an ongoing randomized phase II trial analyzed PFS among patients enrolled from January 2017 through July 2018. Sixty-one patients with relapsed/refractory cHL who were clinically naïve to PD-1 blockade and had received ≥2 previous therapies were randomized 1:2 to receive either camrelizumab (200 mg) monotherapy or camrelizumab (200 mg, day 8) combined with decitabine (10 mg/day, days 1–5) every 3 weeks. Results With a median follow-up of 34.5 months, complete remission was 79% (95% CI 63% to 90%) in the decitabine-plus-camrelizumab group versus 32% (95% CI 13% to 57%) in the camrelizumab group (p=0.001). Median duration of response was not reached in the decitabine-plus-camrelizumab group, with an estimated 63% (95% CI 46% to 75%) of patients maintaining a response at 24 months. Median PFS with decitabine-plus-camrelizumab therapy was 35.0 months (95% CI not reached) and 15.5 months (95% CI 8.4 to 22.7 months) with camrelizumab monotherapy (HR, 0.46; 95% CI 0.21 to 1.01; p=0.02). Female gender, lower tumor burden, and fewer previous therapies were favorable prognostic factors for durable remission with camrelizumab monotherapy. The PFS benefits of decitabine-plus-camrelizumab versus camrelizumab were observed in most subgroups, especially in patients with relative larger tumor burdens and those treated with ≥3 prior therapies. After decitabine-plus-camrelizumab treatment, the percentage increase of circulating peripheral central memory T-cells correlated with both improved clinical response and PFS, suggesting a putative biomarker of decitabine-plus-camrelizumab therapy for cHL. Conclusions Decitabine-plus-camrelizumab results in longer PFS compared with camrelizumab alone in patients with relapsed/refractory cHL. Trial registration numbers NCT02961101 and NCT03250962 .
Contribution of vagal pathways to the renal responses to head-out immersion in the nonhuman primate.
Authors: J PGilmore, I HZucker
Journal: Circulation Research (1978)

Studies were carried out to determine the contribution of cardiopulmonary receptors to the renal responses to head-out water immersion in the nonhuman primate. Immersion to the suprasternal notch was associated with significant increases in central venous pressure, urine flow, and sodium excretion. The increased sodium excretion was due primarily to a significant increase in the percent of the filtered sodium excreted. Deoxycorticosterone acetate (DOCA) and antiduretic hormone (ADH) had no substantial effects on these responses. The finding of a vasopressin-resistant hyposthenuria is consistent with the natriuresis of immersion being due, at least in part, to a decrease in sodium reabsorption proximal to the diluting segment, possibly the proximal tubule. Bilateral cervical vagotomy had no substantial influence on the renal responses to immersion, demonstrating that cardiopulmonary receptors whose axons traverse the vagus nerves are not necessary for the homeostatic adjustments to central hypervolemia in ...
Isoproterenol antagonizes prolongation of refractory period by the class III antiarrhythmic agent E-4031 in guinea pig myocytes. Mechanism of action.
Authors: M CSanguinetti, N KJurkiewicz, AScott, P KSiegl
Journal: Circulation Research (1991)

The mechanism by which isoproterenol (ISO) prevents the prolongation of action potential duration (APD) and refractory period (RP) by the class III antiarrhythmic agent E-4031 was studied. E-4031 (1 microM) increased RP by 50% with no effect on contractile force in papillary muscles isolated from guinea pig heart. ISO (1 microM) increased force of contraction more than fivefold and decreased RP by 25%. The prolongation of RP by E-4031 was prevented by pretreatment of muscles with ISO. The prolongation of APD in isolated guinea pig ventricular myocytes by 5 microM E-4031 also was antagonized by prior exposure of the cells to 1 microM ISO. Instantaneous currents and delayed rectifier K+ currents, IK, were measured in isolated myocytes using the suction microelectrode voltage-clamp technique. Currents were measured in response to 225-msec depolarizing pulses from a holding potential of -40 mV. Previous studies have demonstrated that IK in these cells results from activation of two distinct outward K+ current...
Survival Outcomes After Portal Vein Embolization and Liver Resection Compared With Liver Transplant for Patients With Extensive Colorectal Cancer Liver Metastases
Authors: Svein Dueland, Sheraz Yaqub, Trygve Syversveen, Ulrik Carling, Morten Hagness, Kristoffer W. Brudvik, Pål-Dag Line
Journal: JAMA Surgery (2021)

Portal vein embolization (PVE) has been implemented in patients with extensive colorectal liver metastases to increase the number of patients able to undergo liver resection. Liver transplant could be an alternative in selected patients with extensive liver-only disease, and we have recently shown promising survival outcomes.To compare overall survival (OS) among patients with colorectal cancer and high liver metastasis tumor load who were treated with liver transplant or with PVE and liver resection.This comparative effectiveness research study assessed 50 patients with colorectal cancer liver metastases who were previously enrolled in liver transplant studies between November 2006 and August 2019 at Oslo University Hospital in Norway. Those patients were compared with a retrospective cohort of 53 patients in the Oslo University Hospital PVE database from March 2006 through November 2015 with similar selection criteria who underwent PVE and liver resection.The OS among patients with high tumor load after liver transplant was compared with that among patients with high tumor load who underwent PVE and liver resection. High tumor load was defined as 9 or more metastatic tumors or a diameter of 5.5 cm or longer for the largest liver lesion.In the PVE cohort of 53 patients, the median age was 61.8 years (range, 34.3-71.3 years), and 36 patients (68%) were men. The 5-year OS rate among 38 patients who underwent liver resection after PVE was 44.6%. The 5-year OS rate for patients with high tumor load was 33.4% for those who underwent liver transplant and 6.7% for those who underwent PVE. Among patients with high tumor load and left-sided primary tumors, the 5-year OS rate was 45.3% for those receiving a liver allograft and 12.5% for those treated with PVE and liver resection.Patients with nonresectable disease, an extensive liver tumor load, and left-sided primary tumors had long OS after liver transplant, exceeding the survival outcome for those patients treated with PVE and liver resection.
Time-invariant oxygen cost of mechanical energy in dog left ventricle: consistency and inconsistency of time-varying elastance model with myocardial energetics.
Authors: YYasumura, TNozawa, SFutaki, NTanaka, HSuga
Journal: Circulation Research (1989)

We studied whether the oxygen cost of mechanical energy is time-invariant in the excised, cross-circulated canine heart. The total mechanical energy generated by ventricular contraction can be quantified by the total pressure-volume area (PVA) according to the time-varying elastance model. In this model, mechanical energy generated until a specified time (t) during systole can be quantified by the partial pressure-volume area, PVA(t). PVA(t) was obtained by quickly releasing ventricular volume at a varied time during isovolumic contraction. The quick release aborted further development of mechanical energy. We found that PVA(t) at a constant end-diastolic volume linearly correlated with myocardial oxygen consumption (VO2). This indicates that the oxygen cost of mechanical energy is time-invariant. However, we also found that the slope of the VO2-PVA(t) relation decreased with increasing quick-release speed. This indicates a decrease in VO2 by the quick release despite the same PVA(t). The time-invariant o...
Cholesterol potentiates the coronary artery response to norepinephrine in anesthetized and conscious dogs.
Authors: CRosendorff, J IHoffman, E DVerrier, JRouleau, L EBoerboom
Journal: Circulation Research (1981)

We investigated the effect of hypercholesterolemia on coronary and cardiac hemodynamic responses to intracoronary norepinephrine (NE) (0.01 to 10.0 micrograms/min as the bitartrate) in a Gregg cannula autoperfusion system. Coronary blood flow was measured by the radioactive microsphere technique in two groups of open-chest dogs anesthetized with pentobarbital: 10 controls and 8 that were fed a cholesterol-rich diet (CD) which doubled the serum cholesterol level. In the control dogs, NE in doses of 0.01 to 1.0 micrograms/min had no effect on coronary vascular resistance (CVR) but 10 micrograms/min caused a significant decrease to 0.58 +/- 0.12 of control. In the CD dogs, NE at doses of 1.0 and 10.0 micrograms/min significantly reduced CVR, to 0.72 +/- 0.06 and 0.52 +/- 0.11 of control, respectively. There was no consistent effect of NE, at these doses, on myocardial oxygen uptake, left ventricular stroke work index, or maximal positive dP/dt. In a second series of experiments we measured coronary flow with...
Effects of 12 months of intense exercise training on ischemic ST-segment depression in patients with coronary artery disease.
Authors: A AEhsani, G WHeath, J MHagberg, B ESobel, J OHolloszy
Journal: Circulation (1981)

This study was undertaken to determine whether adaptation to 12 months of intense endurance exercise training could alter the relationship between the product of heart rate and systolic blood pressure (double product) and the extent of ischemic ST-segment depression during exercise in patients with coronary artery disease. True (i.e., not symptom-limited) maximum oxygen uptake capacity increased from 25.5 +/- 4.2 ml/kg/min (mean +/- SD) to 35.3 +/- 4.4 ml/Kg/min with training. The maximum degree of ST-segment depression during exercise averaged 0.20 +/- 0.04 mV before and 0.16 +/- 0.08 mV after training despite a 20% increase in maximum double product. The double product at which ST depression (0.1 mV) first appeared was 22% greater after training. The extent of ST-segment displacement at the same double product was less after training. These findings suggest that training, if sufficiently intense and prolonged, can result in a reduction in myocardial ischemia at the same or a higher double product.
Intracardiac repair of cardiac malformations with atrioventricular discordance.
Authors: L SFox, J WKirklin, A DPacifico, A LWaldo, L MBargeron
Journal: Circulation (1976)

Twenty-six patients with atrioventricular discordance and a variety of ventriculo-arterial connections have had appropriate intracardiac repairs. Seven of 26 patients (26.9%) died early postoperatively, but only two (11.1%) of 18 patients operated upon since May 1972 have died. Ten patients (40%) developed permanent complete heart block. Two patients died late postoperatively; 16 (84.1% of those surviving the early postoperative period) were in NYHA Class I or II at late follow-up. Seventeen of the patients had corrected transposition. Six developed tricuspid incompetence with regurgitation into the left atrium after repair. Two patients with atrioventricular discordance and double outlet right ventricle survived operation and are asymptomatic but have permanent pacemakers. One patient died after repair of double outlet left ventricle with atrioventricular discordance. Three of four patients with atrioventricular discordance and pseudotruncus arteriosus survived repair with valved external conduits an...
日本人冠動脈疾患(JCAD)研究における冠動脈疾患患者の心血管イベントに対するニコランジルの効果
Authors: Toyofuku Mamoru, Ueda Hironori, Masaoka Yoshiko, Muraoka Yuji, Hirao Hidekazu, Okimoto Tomokazu, Ohtsuka Masaya, Tamekiyo Hiromichi, Mito Shinji, Takeda Ryo, Motoda Chikaaki, Watanabe Noriaki, Hayashi Yasuhiko
Journal: Circulation (2010)
Can NBI Alone Accurately Identify GIM In a Low Risk Population Compared with Sydney Protocol? Preliminary Data From a Pilot Study In A Non-Academic Center
Authors: P Kourkoulis, C Kapizioni, G Koutoufaris, K Manoloudaki, P Giannelis, A Mellos, S Vrakas, G Michalopoulos, I Vougadiotis, V Xourgias
Journal: Endoscopy (2021)

Aims The evaluation of Narrow Band Imaging (NBI) outside a tertiary center environment as an assessment method for Gastric Intestinal Metaplasia (GIM) when compared with the established standard of White Light Imaging (WLI) endoscopy with random, Sydney protocol biopsies.