tbuckley/cabot-search huggingface dataset:
Targeting the nasty nestin to shoot lung fibrosis
Authors: Olivier Burgy, Bruno Crestani, Philippe Bonniaud
Journal: European Respiratory Journal (2022)

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal lung disease [1]. Therapeutic options are limited to pirfenidone and nintedanib, which can slow down but not halt or reverse disease progression. The biology of IPF is highly complex and not fully elucidated, although many actors and mechanisms have been identified in the past decades [2]. Notably, the reactivation of developmental signalling pathways such as transforming growth factor (TGF)-β or WNT signalling has been repeatedly observed during IPF [3–5]. The seminal role of TGF-β in organ fibrogenesis, and more particularly in pulmonary fibrosis, has been known for more than a quarter of century [6]. Nevertheless, the reasons why these observations have not yet turned into effective therapy in IPF raise questions. Nestin promotes TGF-β signalling and is a therapeutic target in IPF https://bit.ly/3Km1rEy
ENDOSCOPIC TREATMENT OF ZENKER'S DIVERTICULUM WITH A SURGICAL DEVICE FOR TISSUE SEALING
Authors: G. Rizzo
Journal: Endoscopy (2022)

Using a standard or pediatric gastroscope, we expose the cricopharingeal septum with a “duck’s beak” overtube. Under endoscopic view, we use the Ligasure (a surgical device normally used in laparoscopic surgery) to cut the septum. This allow a precise section, sealing and hemostasis of the tissue. The tip of the device is about 2 cm long, usually no more than 2-3 cuts are necessary.
The health-adjusted dependency ratio as a new global measure of the burden of ageing: a population-based study
Authors: Vegard Skirbekk, Joseph L Dieleman, Marcin Stonawski, Krystian Fejkiel, Stefanos Tyrovolas, Angela Y Chang
Journal: The Lancet Healthy Longevity (2022)

The old-age dependency ratio (OADR), which is the ratio of older people (aged ≥65 years) to working age people (aged 20-64 years), is the most common way to assess and compare the burden of population ageing in different countries. However, the relationship between chronological age and dependency varies widely across countries. We therefore present the health-adjusted dependency ratio (HADR), a new measure of ageing burden based on the ageing-related health of the adult population.In this population-based study we used health data for diseases and injuries for 2017 from the Global Burden of Disease project and population data for 2017 from the UN's Population Division to identify the number of adults (aged >20 years) in each country who have the same or higher ageing-related disease burden as the global average 65-year-old. We then calculated the HADR as the ratio of adults who were less healthy than the average 65-year-old (dependent population) to those in better health (supporting population) and compared the HADR with the OADR for 188 countries. We also used cross-sectional, bivariate regression analysis to investigate whether the HADR is a more powerful predictor of changes in per capita health-care expenditure than the OADR as a measure of predictive validity.Many demographically younger populations have an earlier onset of ageing-related disease, and many demographically older populations have a later onset. For instance, Pakistan has an OADR of 0·09 and an HADR of 0·19, and France has an OADR of 0·35 and an HADR of 0·13. Relative to the OADR, the HADR suggests that Asia, western Europe, and North America have a lower ageing burden, whereas central Asia, southern Asia, and Africa have a greater burden. While Japan and countries in western Europe have the highest OADR, Russia, Papua New Guinea, and countries in southeast Europe have the highest HADR. Relative to the OADR, the HADR suggests that there is much less variation in the burden of ageing across countries than has previously been assumed. HADR was also more closely associated with growth in health spending than the OADR. A 0·1 increase in the HADR was associated with a 2·9 percentage points larger growth rate in per capita spending (p=0·0001), and a 0·1-point increase in the OADR was associated with a 1·8 percentage point larger growth rate.The OADR probably overestimates the burden of population ageing in many demographically older countries and underestimates the ageing burden in many demographically younger countries, which implies that the challenges associated with ageing are more universal than previously thought, and that the world cannot easily be divided in a young and an old groups of nations.None.
160TiP A randomized controlled phase III study of bevacizumab and paclitaxel in combination with atezolizumab as a treatment for patients with locally advanced or metastatic hormone receptor-positive HER2-negative breast cancer: JCOG1919E/AMBITION study
Authors: F. Hara, M. Ono, S. Kitano, T. Nakayama, H. Kawabata, K. Watanabe, K. Sasaki, T. Kataoka, S. Saji, K. Yonemori, T. Shien, H. Iwata
Journal: Annals of Oncology (2022)
200P Increase of vertebral fractures in patients with metastatic breast cancer treated with endocrine therapy combined with CDK 4/6 inhibitor
Authors: L. Lorini, E. Conforti, M. Frigerio, L. Laini, V. Amoroso, A. Alberti, G. Schivardi, P. Di Mauro, D. Cosentini, L. Vassalli, V. Cremaschi, A. Esposito, E.L. Simoncini, R. Gasparotti, A. Berruti, R. Pedersini
Journal: Annals of Oncology (2022)
IMPACT OF ANTIBIOTIC PROPHYLAXIS ON INFECTION RATE AFTER ENDOSCOPIC ULTRASOUND THROUGH-THE-NEEDLE BIOPSY OF PANCREATICCYSTS: A PROPENSITY SCORE MATCHED STUDY
Authors: A. Facciorusso, M. Arevalo-Mora, M.C. Conti Bellocchi, L. Bernardoni, D. Ramai, P. Gkolfakis, D. Loizzi, N. Muscatiello, A. Ambrosi, N. Tartaglia, C. Robles-Medranda, S.F. Crinò
Journal: Endoscopy (2022)

Aims Despite the weak evidence, antibiotic prophylaxis prior to endoscopic ultrasound-guided through-the-needle biopsy (EUS-TTNB) of pancreatic cystic lesions (PCLs) is routinely used in the clinical practice. We aim to compare a group of patients treated with antibiotics before EUS-TTNB of PCLs and a group who did not undergo antimicrobial prophylaxis.
G-POEM IN REFRACTORY GASTROPARESIS, FOR WHOM? LONG TERM OUTCOMES AND PREDICTIVE SCORE TO IMPROVE PATIENT SELECTION
Authors: A. Labonde, G. Lades, A. Debourdeau, O. Ragi, L. Lehmann, V. Vitton, M. Barthet, R. Legros, J. Albouys, S. Geyl, V. Loustaud-Ratti, J. Monteil, S. Gonzalez, J.M. Gonzalez, J. Jacques
Journal: Endoscopy (2022)

Aims Limited data exist concerning the long-term efficiency of G-POEM as a treatment of refractory gastroparesis. This study evaluates the 3-year results of G-POEM in patients with refractory gastroparesis, then investigated predictive factors for procedure success or failure.
THE IMPACT OF COVID-19 ON SURVEILLANCE OF PATIENTS WITH PANCREATIC CYSTIC NEOPLASMS (PCN)
Authors: S. Sengupta, B. Kelleher, J. Leyden, G. Bennett, C. Murphy
Journal: Endoscopy (2022)

Aims Correct surveillance of Pancreatic cystic neoplasms (PCN) may prevent progression to pancreatic cancer. European guidelines recommend MRI surveillance of PCN's in suitable patients. The COVID-19 pandemic has impacted cancer surveillance programs in Ireland.
CLINICOPATHOLOGIC PROFILES, ENDOSCOPIC FEATURES AND OUTCOMES OF PATIENTS WITH YOUNG-ONSET COLORECTAL CANCER AT THE UNIVERSITY OF THE PHILIPPINES – PHILIPPINE GENERAL HOSPITAL
Authors: M.D. Velasco, D.B. Sacdalan, D. Sacdalan, F. Zano
Journal: Endoscopy (2022)

Aims This study aims to describe endoscopic findings in young CRC patients (in addition to the clinical, pathologic features and outcomes).
SAFETY OF A NOVEL 1L-POLYETHYLENE GLYCOL-ASCORBATE SOLUTION FOR COLONOSCOPY CLEANSING (REAL STUDY)
Authors: M. Manno, P. Biancheri, G.F. Bonura, T. Gabbani, J. Rainer, A. Curatolo, S. Deiana, G. Impellizzeri, L. Ottaviani, C. Hassan, A. Repici, P. Soriani
Journal: Endoscopy (2022)

Aims Very low-volume bowel preparation (BP) for colonoscopy with one liter polyethylene glycol plus ascorbate (1L-PEG-Asc) has displayed high tolerability, compliance, and quality of bowel cleansing. However, concerns have been raised regarding the safety of 1L-PEG-Asc. In our study, we aimed to evaluate the incidence of adverse events (AEs) following BP with 1L-PEG-Asc or 2L-PEG-Asc.
LOW COST REAL-TIME COLONOSCOPY PROCESSING WITH DEEP LEARNING
Authors: V. Drug, A. Ciobanu, M. Luca, R. Vulpoi, A. Olteanu, O. Barboi
Journal: Endoscopy (2022)

Aims Developing a low cost microsystem that can automatically identify in real-time different entities during a colonoscopy. It is based on a pre-trained deep learning neural network retrained on 700 annotated frames. The trained network works on a Jetson Xavier NX microsystem from NVIDIA.
BLACK ESOPHAGUS – ACUTE NECROTIZIN ESOPHAGITIS (ANE)
Authors: J. Válek
Journal: Endoscopy (2022)

Aims Acute necrotizing esophagitis is a rare disease diagnosed in critically ill patients. It arises from the corrosive effect of gastric juices on the susceptible, ischemic esophageal mucosa. The main symptoms are coffee ground emesis, melena, dysphagia and epigastric pain. Typically in the distal esophagus we see circumferential, black-appearing esophageal mucosa that sharply stops at the GEJ. The patient is kept nil per os and sufficiently intravenously hydrated. Antibiotics and PPI are also given intravenously. Mediastinitis due to esophageal perforation is a severe complication. Chronic complication is a stenosis treated by balloon dilation.
PROVIDING THE PATHOLOGIST WITH CLINICAL INFORMATION IMPROVES THE READING AND INTERPRETATION OF EUS-GUIDED TISSUE ACQUISITION OF SOLID PANCREATIC LESIONS
Authors: H.M. Schutz, R. Quispel, M. van Velthuysen, M.J. Bruno, L.M. van Driel
Journal: Endoscopy (2022)

Aims EUS-guided tissue acquisition is the most sensitive method to collect tissue samples of solid pancreatic lesions. The availability of clinical information might aid the pathologist’s ability to establish a diagnosis. The aim of this study was to investigate the diagnostic accuracy and agreement of cytotechnicians and pathologists in the evaluation of EUS-FNA samples of solid pancreatic lesions and the impact of clinical information on agreement and diagnostic accuracy.
IMPACT OF COVID-19 PANDEMIC ON COLONOSCOPY ACTIVITY
Authors: R. Tababi, S. Mrabet, A. Hassine, R. Harbi, A. Imen, A. Hassine, E. Ben Jazia
Journal: Endoscopy (2022)

Aims Coronavirus disease 2019 (COVID19) pandemic has plainly restrained activities in healthcare facilities, notably the ability to carry out colonoscopy. The purpose of this study was to assess the repercussions on colonoscopy load as well as its indications and findings.
SAFETY AND EFFICACY OF DEVICE-ASSISTED ENTEROSCOPY (DOUBLE BALLOON) FOR EXTRACTION OF PLASTIC STENTS
Authors: R. Barreto- Zuniga, L.E. Zamora-Nava, X. Sanchez-Chavez
Journal: Endoscopy (2022)

Aims Evaluate safety and efficacy of device-assisted enteroscopy (double balloon) for removal plastic stents retained in the small intestine.
DEVELOPMENT AND VALIDATION OF DEEP LEARNING-BASED AUTOMATIC SEMI-STRUCTURED UPPER GASTROINTESTINAL ENDOSCOPIC REPORTING SYSTEM
Authors: L. Zhang, Z. Lu, L. Yao, H. Yu
Journal: Endoscopy (2022)

Aims Gastrointestinal endoscopy is one of the most common technique for gastrointestinal disorders. The endoscopy report is essential for facilitating diagnosis, therapy strategic decision, clinical recommendations, further consultation and following-up. To ensure adequate quality of endoscopy report, minimal standard terminology and semi-structured formation were recommended by guidelines. However, manual endoscopic reporting is time-consuming, with significant heterogeneity among endoscopists and clinical environment. We aimed to develop and validate a deep learning-based automatic semi-structured upper gastrointestinal endoscopic reporting system.
147P Breast cancer in women with germline pathogenic variants: Frequency, clinical behavior, and outcomes of a consecutive series of patients from Spain
Authors: A. Rodriguez Hernandez, F. Braso Maristany, B. Pastor, M. Potrony, L. Moreno, E. Grau, J.A. Puig-Butille, O. Martinez Saez, B. Conte, N. Chic, M.J. Vidal Losada, M. Munoz, F. Balaguer, A. Prat, B. Adamo
Journal: Annals of Oncology (2022)
171P Biomarker and multivariate analyses results from AIPAC: A phase IIb study comparing eftilagimod alpha (a soluble LAG-3 protein) vs placebo in combination with weekly paclitaxel in HR+ HER2- metastatic breast cancer
Authors: F. Marmé, H. Wildiers, L. Dirix, A. Armstrong, E. De Cuypere, F. Dalenc, C. Pia Schröder, P. Vuylsteke, E. Brain, S. Kuemmel, Z. Pápai, C. Mueller, C. Brignone, F. Triebel
Journal: Annals of Oncology (2022)
Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV): a randomised controlled trial
Authors: Javier Delgado-Lista, Juan F Alcala-Diaz, Jose D Torres-Peña, Gracia M Quintana-Navarro, Francisco Fuentes, Antonio Garcia-Rios, Ana M Ortiz-Morales, Ana I Gonzalez-Requero, Ana I Perez-Caballero, Elena M Yubero-Serrano, Oriol A Rangel-Zuñiga, Antonio Camargo, Fernando Rodriguez-Cantalejo, Fernando Lopez-Segura, Lina Badimon, Jose M Ordovas, Francisco Perez-Jimenez, Pablo Perez-Martinez, Jose Lopez-Miranda, Juan F Alcala-Diaz, Yolanda Almaden Peña, Enrique Aranda, Antonio P Arenas de Larriva, Lina Badimon, Juan J Badimon, Angeles Blanco-Molina, Ruth Blanco-Rojo, Julia Bolivar-Muñoz, Javier Caballero-Villarraso, Antonio Camargo, Javier Chica, Andreea Corina, Juan Criado-Garcia, Cristina Cruz-Teno, Antonio Daponte-Codina, Eduardo de Teresa Galvan, Nieves Delgado-Casado, Javier Delgado-Lista, Ramon Estruch, Juan M Fernandez, Carolina Fernandez-Gandara, Francisco Fuentes-Jimenez, Sonia Garcia-Carpintero Fernandez-Pacheco, Antonio Garcia-Rios, Francisco Gomez-Delgado, Angela Gomez-Garduño, Purificacion Gomez-Luna, Maria J Gomez-Luna, Lorena Gonzalez-Guardia, Ana I. Gonzalez-Requero, Francisco M Gutierrez-Mariscal, Carmen M Haro-Mariscal, Rosa Jimenez-Lucena, Ana I. Jimenez-Morales, Ana Leon-Acuña, Jose Lopez-Miranda, Fernando Lopez-Segura, Carmen Marin-Hinojosa, Maria E Meneses Alvarez, Dolores Mesa-Luna, Maria N Moya-Garrido, Ignacio Muñoz-Carvajal, Vanessa Navarro-Martos, Juan J Ochoa, Jose M Ordovas, Juan A Ortiz-Minuesa, Ana M Ortiz-Morales, Manuel Pan, Patricia Peña-Orihuela, Ana I Perez-Caballero, Isabel Perez-Corral, Francisco Perez-Jimenez, Pablo Perez-Martinez, Francesc X Pi-Sunyer, Gracia M Quintana-Navarro, Irene Ramirez-Lara, Oriol A Rangel-Zuñiga, Fernando Rodriguez-Artalejo, Fernando Rodriguez-Cantalejo, Miguel A Romero, Irene Roncero-Ramos, Juan A. Ruano-Ruiz, Joaquin Ruiz de Castroviejo, Pablo Sanchez-Villegas, Jose Suarez de Lezo, Javier Suarez de Lezo, Jose D Torres-Peña, Cristina Vals-Delgado, Roberto Valverde, Francisco Visioli, Elena M Yubero-Serrano
Journal: The Lancet (2022)
112P Patients’ knowledge about ductal carcinoma in situ
Authors: E.G. Engelhardt, R. Schmitz, M. Gerritsma, C. Sondermeijer, E. Verschuur-van der Voort, M. van Oirsouw, V. Retel, F.H. van Duijnhoven, J. Wesseling, E. Bleiker
Journal: Annals of Oncology (2022)
JAGGED-NOTCH3 signaling in vascular remodeling in pulmonary arterial hypertension
Authors: Yu Zhang, Moises Hernandez, Jonathan Gower, Nolan Winicki, Xena Morataya, Sebastian Alvarez, Jason X.-J. Yuan, John Shyy, Patricia A. Thistlethwaite
Journal: Science Translational Medicine (2022)

Within the pulmonary arterial tree, the NOTCH3 pathway is crucial in controlling vascular smooth muscle cell proliferation and maintaining smooth muscle cells in an undifferentiated state. Pulmonary arterial hypertension (PAH) is a fatal disease without cure, characterized by elevated pulmonary vascular resistance due to vascular smooth muscle cell proliferation in precapillary arteries, perivascular inflammation, and asymmetric neointimal hyperplasia. Here, we show that human PAH is characterized by overexpression of the NOTCH ligand JAGGED-1 (JAG-1) in small pulmonary artery smooth muscle cells and that JAG-1 selectively controls NOTCH3 signaling and cellular proliferation in an autocrine fashion. In contrast, the NOTCH ligand DELTA-LIKE 4 is minimally expressed in small pulmonary artery smooth muscle cells from individuals with PAH, inhibits NOTCH3 cleavage and signaling, and retards vascular smooth muscle cell proliferation. A new monoclonal antibody for the treatment of PAH, which blocks JAG-1 cis- and trans-induced cleavage of the NOTCH3 receptor in the pulmonary vasculature, was developed. Inhibition of JAG-1-induced NOTCH3 signaling in the lung reverses clinical and pathologic pulmonary hypertension in two rodent models of disease, without toxic side effects associated with nonspecific NOTCH inhibitors. Our data suggest opposing roles of NOTCH ligands in the pulmonary vasculature in pulmonary hypertension. We propose that selectively targeting JAG-1 activation of NOTCH3 may be an effective, safe strategy to treat PAH.
CT-COLONOGRAPHY IN FECAL IMMUNOCHEMICAL TEST POSITIVE PATIENTS IN A COLORECTAL CANCER SCREENING PROGRAM – YIELD AND INCIDENCE OF INTERVAL CARCINOMAS
Authors: S. Moen, F.E. Marijnissen, J.S. Terhaar Sive Droste, W.H. de Vos tot Nederveen Cappel, M.B.W. Spanier, J.F. Huisman, E. Dekker, J. Stoker, E.J. Kuipers, M.G.J. Thomeer, M.C.W. Spaander
Journal: Endoscopy (2022)

Aims In the Dutch colorectal cancer (CRC) screening program, fecal immunochemical test (FIT) positive screenees are offered CT-colonography (CTC) when colonoscopy is not possible due to contraindications or patient preferences. Literature on CTC screening in FIT-positives is scarce and incidence of interval carcinomas for this population is yet unknown.
Dual-functional hydrogel system for spinal cord regeneration with sustained release of arylsulfatase B alleviates fibrotic microenvironment and promotes axonal regeneration
Authors: Hee Hwan Park, Young-Min Kim, Le Thi Anh Hong, Hyung Soon Kim, Sung Hoon Kim, Xuelian Jin, Dong Hoon Hwang, Min Jung Kwon, Soo-Chang Song, Byung Gon Kim
Journal: Biomaterials (2022)

Traumatic damage to the spinal cord does not spontaneously heal, often leading to permanent tissue defects. We have shown that injection of imidazole-poly(organophosphazene) hydrogel (I-5) bridges cystic cavities with the newly assembled fibronectin-rich extracellular matrix (ECM). The hydrogel-created ECM contains chondroitin sulfate proteoglycans (CSPGs), collagenous fibrils together with perivascular fibroblasts, and various fibrotic proteins, all of which could hinder axonal growth in the matrix. In an in vitro fibrotic scar model, fibroblasts exhibited enhanced sensitivity to TGF-β1 when grown on CSPGs. To alleviate the fibrotic microenvironment, the I-5 hydrogel was equipped with an additional function by making a complex with ARSB, a human enzyme degrading CSPGs, via hydrophobic interaction. Delivery of the I-5/ARSB complex significantly diminished the fibrotic ECM components. The complex promoted serotonergic axonal growth into the hydrogel-induced matrix and enhanced serotonergic innervation of the lumbar motor neurons. Regeneration of the propriospinal axons deep into the matrix and to the lumbar spinal cord was robustly increased accompanied by improved locomotor recovery. Therefore, our dual-functional system upgraded the functionality of the hydrogel for spinal cord regeneration by creating ECM to bridge tissue defects and concurrently facilitating axonal connections through the newly assembled ECM.
CONTRIBUTION OF ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY (ERCP) IN THE MANAGEMENT OF RUPTURED LIVER HYDATIDOSIS CYST IN THE BILE DUCTS
Authors: I. Ferchichi, M. Yakoubi, K. Ben Abdallah, A. Khsiba, A. Ben Mohamed, M. Mahmoudi, M. Medhioub, M.l. Hamzaoui, M.M. Azouz
Journal: Endoscopy (2022)

Aims Assess the contribution of retrograde cholangiopancreatography (ERCP) in the management of liver hydatitosis cyst in the bile ducts.
MAKING AND ENDOSCOPIC ULTRASONOGRAFIC GUIDED COLO-RECTAL NEO-ANASTOMOSIS: THE CLOSE ENCOUNTER OF TWO LIGHTS
Authors: A.L. Vargas García, M. Alburquerque, E. Pijoan, M. Figa, F. González-Húix
Journal: Endoscopy (2022)

A 75 years-old female underwent anterior resection for rectosigmoid adenocarcinoma 3 months ago with the appearance of anastomotic leak so a loop ileostomy was made. During follow-up colonoscopy, an insurmountable anastomotic stricture was observed. Due to this finding, patient was referred to our center. We performed a transanal colonoscopy where a close anastomosis at 3-4cm from pectinate line was identified and other colonoscopy through stoma till the anastomosis where only a blind hole was observed. After many attempts to pass the guidewire through both anastomotic sides and patient’s refuse to surgery, an endoscopic ultrasonographic guided colorectal neo-anastomosis was made.
SALVAGING EUS-GUIDED HEPATICOGASTROSTOMY UTILIZING “CONTROLLING THE TWO ENDS OF THE WIRE” TECHNIQUE IN THE TREATMENT OF A COMPLEX MALIGNANT HILAR STRICTURE
Authors: M. Lajin
Journal: Endoscopy (2022)

A 70-year-old male presented with stage 4 cholangiocarcinoma resulting in hilar obstruction. After a failed ERCP, EUS-guided hepaticogastrostomy was attempted.
ACCESSIBILITY TO ENDOSCOPIC RESECTION OF COLORECTAL NEOPLASTIC LESIONS≥20MM IN A REFERRAL CENTER: WHAT WAS THE COVID-19 PANDEMIC IMPACT?
Authors: M. Sarmento Costa, A.R. Graça, E. Gravito-Soares, M. Gravito-Soares, P. Amaro, P. Figueiredo
Journal: Endoscopy (2022)

Aims Advanced endoscopic resection (ER) for complex colorectal polyps is accessible only in referral centers. Accessibility is not yet stated in quality European guidelines for colonoscopy.
212P A cohort study on the immunogenicity and safety of the inactivated SARS-CoV-2 vaccine (BBIBP-CorV) in patients with breast cancer: Does trastuzumab interfere with the outcome?
Authors: S.A. Javadinia, M. Dehghani, M. Ariamanesh, Z. Roudsarabi
Journal: Annals of Oncology (2022)
178P Assessment of side effects (SEs) impacting quality of life (QoL) in patients (pts) undergoing treatment (tx) for advanced breast cancer (ABC) in clinical practice: A real-world (RW) multi-country survey
Authors: F. Cardoso, J. Rihani, D. Aubel, J. de Courcy, V. Harmer, N. Harbeck, A. Casas, H.S. Rugo, P.A. Fasching, S. Haftchenary, P. Pathak, E. Schumacher-Wulf
Journal: Annals of Oncology (2022)
180P A doubling in overall survival of patients with de novo HER2+ advanced breast cancer in the Netherlands
Authors: S.M.E. Geurts, K. Ibragimova, M. Meegdes, F.L.G. Erdkamp, J.B. Heijns, J. Tol, B.E.P.J. Vriens, W. Dercksen, K.N.A. Aaldering, M.J.A.E. Pepels, L.V.D. Winkel, N. Peters, A.J. van de Wouw, A. Hochstenbach, M. De Boer, V.C.G. Tjan-Heijnen
Journal: Annals of Oncology (2022)
3MO Association of the research-based HER2DX signatures with survival in early-stage triple-negative breast cancer (eTNBC)
Authors: B. Conte, F. Brasó-Maristany, T. Pascual, F. Schettini, J. Staaf, L. Paré, M. Marín-Aguilera, O. Martínez-Sáez, A. Rodriguez Hernandez, M.J. Vidal Losada, P.F. Conte, A. Vivancos, P. Villagrasa Gonzalez, J. Parker, C.M. Perou, A. Prat
Journal: Annals of Oncology (2022)
CORRELATION OF FINDINGS OF COLITIS ON CT COMPARED TO COLONOSCOPY
Authors: T. Kahn
Journal: Endoscopy (2022)

Aims Colonic wall thickening (“colitis”) is often reported on CT scans and poses a dilemma on whether colonoscopy is required. Previous studies show that CT “colitis” has a correlation of 69% with abnormal colonoscopic findings. We aimed to correlate CT findings of colitis with colonoscopy findings.
SECOND-LOOK UPPER ENDOSCOPY AS THE INITIAL APPROACH TO SUBEPITHELIAL LESIONS: A REASSURING AND RELIABLE STRATEGY
Authors: T. Lima Capela, V. Macedo Silva, M. Freitas, T. Cúrdia Gonçalves, F. Dias de Castro, J. Magalhães, S. Leite, J. Cotter
Journal: Endoscopy (2022)

Aims Subepithelial lesions(SEL) of upper gastrointestinal tract are frequent on upper gastrointestinal endoscopy(UGE) but robust data regarding their management is lacking. Although endoscopic ultrasound(EUS) is important in the diagnosis and management of SEL, many can be classified only by a thorough UGE, reducing the burden of additional studies. We aimed to analyze the impact of a stepwise approach starting with an UGE prior to the decision of EUS in patients with suspected SEL.