tbuckley/cabot-search huggingface dataset:
Abstract PO-44: Past infection and risk of adolescent/young adult HL
Authors: Maryam Saleh, Amie Hwang, Julia Simon, Thomas M. Mack, Tim Waterboer, Wendy Cozen
Journal: Blood Cancer Discovery (2020)

Abstract Background: Adolescent/young adult (AYA) Hodgkin lymphoma (HL) risk is increasingly linked to a deficit of microbial exposure in early life, especially from fecal-oral transmission. Methods: In this cross-sectional study, we examined past exposure to 15 infections in serum samples from 291 AYA HL cases and 194 of their unaffected family members. We measured antibodies to HSV1, HSV2, VZV, EBV, HHV7, HCMV, HHV6, KSHV, S. gallolyticus, F. nucleatum, T. gondii, H. pylori, Rubella virus, and Parvovirus B19 using a multiplex serology bead array (Luminex). A positive history was determined by a titer threshold specific for each infection. A logistic regression model was used to calculate the odds ratio (OR) of AYA HL risk for each infection separately adjusted for sex and age at sampling. We then applied the same logistic regression model, adding an adjustment for family. Results: Evidence of past HHV6 infection was associated with an increased risk of AYA HL (OR= 1.80; 95% CI= 1.06-3.07). Having antibodies to H. pylori was associated with a decreased risk (OR= 0.49; 95% CI= 0.25-0.98). An increasing number of fecal-oral infections (H. pylori, T. gondii) was associated with a decreasing risk of AYA HL (ptrend&amp;lt;0.001), while an increasing number of respiratory-transmitted infections (Rubella virus, Parvovirus) was not significantly associated (ptrend=0.062). After adjusting for family, infection with Parvovirus was the only significant risk factor for AYA HL (OR=3.8,1.06-13.6). Conclusions: We show preliminary evidence for an inverse association between fecal-oral transmitted agents and risk of AYA HL, supporting the hypothesis that a deficit of early life fecal-oral transmitted microbes may be associated with increased risk. HHV6 and Parvovirus were associated with an increased risk, possibly due to a subclinical immune deficiency or an unknown mechanism. In the final presentation, we will add data from 40 additional unaffected family members currently missing age, and results by histology and EBV status. Citation Format: Maryam Saleh, Amie Hwang, Julia Simon, Thomas M. Mack, Tim Waterboer, Wendy Cozen. Past infection and risk of adolescent/young adult HL [abstract]. In: Proceedings of the AACR Virtual Meeting: Advances in Malignant Lymphoma; 2020 Aug 17-19. Philadelphia (PA): AACR; Blood Cancer Discov 2020;1(3_Suppl):Abstract nr PO-44.
Effect of Bruton tyrosine kinase inhibitor on efficacy of adjuvanted recombinant hepatitis B and zoster vaccines
Authors: Christopher Pleyer, Mir A. Ali, Jeffrey I. Cohen, Xin Tian, Susan Soto, Inhye E. Ahn, Erika M. Gaglione, Pia Nierman, Gerald E. Marti, Charles Hesdorffer, Jennifer Lotter, Jeanine Superata, Adrian Wiestner, Clare Sun
Journal: Blood (2020)
Re: Ashley M. Hopkins, Ganessan Kichenadasse, Christos S. Karapetis, et al. Concomitant Antibiotic Use and Survival in Urothelial Carcinoma Treated with Atezolizumab. Eur Urol 2020;78:540–3
Authors: Satoshi Funada, Takashi Yoshioka, Yan Luo
Journal: European Urology (2020)
Abstract 11113: Alcohol Consumption and Ideal Cardiovascular Health in the General Population: From the Third National Health and Nutrition Examination Survey
Authors: Muhammadimtiaz Ahmad, Parag A Chevli, Mohamed F Almahmoud, Morgana Mongraw-Chaffin, Kristina H Lewis, Elsayed Z Soliman
Journal: Circulation (2019)

Introduction: While it is established that excess alcohol consumption is associated with poor cardiovascular health (CVH), the association of moderate consumption with ideal CVH and whether this as...
18245 Polymicrobial composition of psoriatic skin
Authors: Kory P. Schrom, Iman Salem, CWRU, Sherman Chu, Mauricio Retuerto, Seunghee P. Margevicius, Ming Li, Neil J. Korman, Mahmoud Ghannoum, Thomas S. McCormick, Kevin D. Cooper
Journal: Journal of the American Academy of Dermatology (2020)
Coaxial-printed small-diameter polyelectrolyte-based tubes with an electrostatic self-assembly of heparin and YIGSR peptide for antithrombogenicity and endothelialization
Authors: Zhiwen Zeng, Chengshen Hu, Qingfei Liang, Lan Tang, Delin Cheng, Changshun Ruan
Journal: Bioactive Materials (2020)

Low patency ratio of small-diameter vascular grafts remains a major challenge due to the occurrence of thrombosis formation and intimal hyperplasia after transplantation. Although developing the functional coating with release of bioactive molecules on the surface of small-diameter vascular grafts are reported as an effective strategy to improve their patency ratios, it is still difficult for current functional coatings cooperating with spatiotemporal control of bioactive molecules release to mimic the sequential requirements for antithrombogenicity and endothelialization. Herein, on basis of 3D-printed polyelectrolyte-based vascular grafts, a biologically inspired release system with sequential release in spatiotemporal coordination of dual molecules through an electrostatic self-assembly was first described. A series of tubes with tunable diameters were initially fabricated by a coaxial extrusion printing method with customized nozzles, in which a polyelectrolyte ink containing of ε-polylysine and sodium alginate was used. Further, dual bioactive molecules, heparin with negative charges and Tyr-Ile-Gly-Ser-Arg (YIGSR) peptide with positive charges were layer-by-layer assembled onto the surface of these 3D-printed tubes. Due to the electrostatic interaction, the sequential release of heparin and YIGSR was demonstrated and could construct a dynamic microenvironment that was thus conducive to the antithrombogenicity and endothelialization. This study opens a new avenue to fabricate a small-diameter vascular graft with a biologically inspired release system based on electrostatic interaction, revealing a huge potential for development of small-diameter artificial vascular grafts with good patency.
Abstract 15496: Young Female With Chest Pain: Going Beyond the Obvious
Authors: Sebastian Gallo-Bernal, Azucena Martinez Caballero, Juan F Vásquez, Nicolas Isaza, Daniel Isaza, Claudia Jaimes
Journal: Circulation (2019)

A 19-year-old woman presented to the emergency department with sudden onset of substernal, oppressive chest pain accompanied by severe shortness of breath. Three months earlier, after a spontaneous...
Abstract PO-055: Pan-cancer metabolic profiling of the tumor microenvironment
Authors: Neha Rohatgi, Umesh Ghoshdastider, Probhonjon Baruah, Anders Jacobsen Skanderup
Journal: Cancer Research (2020)

Abstract Tumors are heterogeneous cellular environments with entwined metabolic dependencies. However, it is challenging to differentially profile metabolism in cancer and infiltrating non-malignant cells inside patient tumors. Here, we used a tumor transcriptome deconvolution approach to profile the metabolic states of cancer and non-cancer (stromal) cells in bulk tumors of 20 solid tumor types. This analysis highlighted metabolic genes and processes recurrently upregulated in cancer cells across tumor types, including the mitochondrial dicarboxylate carrier SLC25A10. Intriguingly, the tryptophan-degrading dioxygenase, IDO1, was highly recurrently overexpressed in stroma compared to cancer cells and normal tissue, suggesting that tryptophan-mediated suppression of antitumor immune response is predominantly constrained by the stroma. Oxidative phosphorylation was unexpectedly the most upregulated metabolic process in cancer cells compared to both stromal cells and a large atlas of cancer cell lines, suggesting that the warburg effect may be less pronounced in cancer cells in vivo. Overall, our analysis highlights fundamental differences in metabolic states of cancer and stromal cells inside tumors and establishes a pan-cancer resource to interrogate tumor metabolism. Citation Format: Neha Rohatgi, Umesh Ghoshdastider, Probhonjon Baruah, Anders Jacobsen Skanderup. Pan-cancer metabolic profiling of the tumor microenvironment [abstract]. In: Abstracts: AACR Special Virtual Conference on Epigenetics and Metabolism; October 15-16, 2020; 2020 Oct 15-16. Philadelphia (PA): AACR; Cancer Res 2020;80(23 Suppl):Abstract nr PO-055.
Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities
Authors: Xiufang Xu, Miaofeng Zhang, Faying Xu, Shaojie Jiang
Journal: Molecular Cancer (2020)

Abstract Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling embryonic and organ development, as well as cancer progression. Genome-wide sequencing and gene expression profile analyses have demonstrated that Wnt signaling is involved mainly in the processes of breast cancer proliferation and metastasis. The most recent studies have indicated that Wnt signaling is also crucial in breast cancer immune microenvironment regulation, stemness maintenance, therapeutic resistance, phenotype shaping, etc. Wnt/β-Catenin, Wnt–planar cell polarity (PCP), and Wnt–Ca 2+ signaling are three well-established Wnt signaling pathways that share overlapping components and play different roles in breast cancer progression. In this review, we summarize the main findings concerning the relationship between Wnt signaling and breast cancer and provide an overview of existing mechanisms, challenges, and potential opportunities for advancing the therapy and diagnosis of breast cancer.
Influence of socioeconomic deprivation on interventions and outcomes for patients admitted with COVID-19 to critical care units in Scotland: A national cohort study
Authors: Nazir I Lone, Joanne McPeake, Neil I Stewart, Michael C Blayney, Robert Chan Seem, Lorraine Donaldson, Elaine Glass, Catriona Haddow, Ros Hall, Caroline Martin, Martin Paton, Alison Smith-Palmer, Callum T Kaye, Kathryn Puxty
Journal: The Lancet Regional Health - Europe (2021)

Coronavirus disease 2019 (COVID-19) can lead to significant respiratory failure with between 14% and 18% of hospitalised patients requiring critical care admission. This study describes the impact of socioeconomic deprivation on 30-day survival following critical care admission for COVID-19, and the impact of the COVID-19 pandemic on critical care capacity in Scotland.This cohort study used linked national hospital records including ICU, virology testing and national death records to identify and describe patients with COVID-19 admitted to critical care units in Scotland. Multivariable logistic regression was used to assess the impact of deprivation on 30-day mortality. Critical care capacity was described by reporting the percentage of baseline ICU bed utilisation required.There were 735 patients with COVID-19 admitted to critical care units across Scotland from 1/3/2020 to 20/6/2020. There was a higher proportion of patients from more deprived areas, with 183 admissions (24.9%) from the most deprived quintile and 100 (13.6%) from the least deprived quintile. Overall, 30-day mortality was 34.8%. After adjusting for age, sex and ethnicity, mortality was significantly higher in patients from the most deprived quintile (OR 1.97, 95%CI 1.13, 3.41, p=0.016). ICUs serving populations with higher levels of deprivation spent a greater amount of time over their baseline ICU bed capacity.Patients with COVID-19 living in areas with greatest socioeconomic deprivation had a higher frequency of critical care admission and a higher adjusted 30-day mortality. ICUs in health boards with higher levels of socioeconomic deprivation had both higher peak occupancy and longer duration of occupancy over normal maximum capacity.None.
Management of fistula between neobladder and rectum using an atrial septal defect closure device
Authors: Ashlee Sidhu, Nagoor Basha Shaik, Malay Sharma
Journal: Endoscopy (2020)

Radiation therapy is widely used to treat malignancies in the pelvic cavity such as cancers of the colorectum, urinary tract, uterus, adnexa, and prostate. Studies have reported pelvic radiotherapy to have been closely associated with gastrointestinal complications such as mucosal ulcers, stenosis, perforation, and fistula formation [1].
Diversity of human papillomavirus in the anal canal of HIV-positive and HIV-negative men
Authors: Luisa Galati, Rosario N. Brancaccio, Purnima Gupta, Eugenie Lohmann, Alexis Robitaille, Racheal S. Dube Mandishora, Cyrille Cuenin, Raffaele Filotico, Jean-Damien Combes, Anna R. Giuliano, Maria Gabriella Donà, Massimo Tommasino, Tarik Gheit
Journal: Journal of Infection (2020)
Abstract 13088: Human Telomerase M-RNA Rescues Cellular Functions, Gene Regulation, and Chromatin Structure in Progeria Ipsc- Derived Endothelial Cells
Authors: Anahita Mojiri, Gianfranco Matrone, Brandon K Walther, Crystina Kriss, John P Cooke
Journal: Circulation (2019)

Hutchinson-Gilford progeria syndrome (HGPS) is a progressive aging syndrome caused by a single mutation (C1824T) in the Lamin A/C gene (LMNA). These patients succumb in their teen years to accelera...
Mixed Apnea Metrics in Obstructive Sleep Apnea Predict Treatment-Emergent Central Sleep Apnea
Authors: Katja Pavsic, Simon Herkenrath, Marcel Treml, Lars Hagmeyer, Rami N. Khayat, Martin Hellmich, Winfried J. Randerath
Journal: American Journal of Respiratory and Critical Care Medicine (2020)

"Mixed Apnea Metrics in Obstructive Sleep Apnea Predict Treatment-Emergent Central Sleep Apnea." American Journal of Respiratory and Critical Care Medicine, 203(6), pp. 772–775
<i>Notes from the Field:</i>Interpretation of Rapid Diagnostic Tests for Leptospirosis During a Dengue Outbreak — Yap State, Federated States of Micronesia, 2019
Authors: Patrick Dawson, Maria Marfel, Renee Galloway, Aileen Tareg, Gabriela Paz-Bailey, Jorge L. Muñoz-Jordán, Tyler M. Sharp, Laura E. Adams, William A. Bower
Journal: MMWR Morbidity and Mortality Weekly Report (2020)
Complementary and synergistic effects on osteogenic and angiogenic properties of copper-incorporated silicocarnotite bioceramic: In vitro and in vivo studies
Authors: Qiang Wu, Shunxiang Xu, Xin Wang, Bo Jia, Yu Han, Yifu Zhuang, Ye Sun, Zhenyu Sun, Yaping Guo, Huamin Kou, Congqin Ning, Kerong Dai
Journal: Biomaterials (2020)
A Text-Book Upon Pathogenic Bacteria for Students of Medicine and Physicians.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
320P Psychometric interplay of the perception of the real-life impact of COVID-19 pandemic: A cross-sectional survey of patients with newly diagnosed malignancies
Authors: K. Bao, K.M. Cheung, J.C.H. Chow, T.Y.M. Tsui, A. Lau, W. Tsui, K.H. Wong
Journal: Annals of Oncology (2020)
Magnesium-pretreated periosteum for promoting bone-tendon healing after anterior cruciate ligament reconstruction
Authors: Jiali Wang, Jiankun Xu, Xinluan Wang, Liyuan Sheng, Lizhen Zheng, Bin Song, Ge Wu, Ri Zhang, Hao Yao, Nianye Zheng, Michael Tim Yun Ong, Patrick Shu-hang Yung, Ling Qin
Journal: Biomaterials (2020)
Recent patents in allergy and immunology: New pyrazinones for the diagnosis of allergies to aminocephalosporins
Authors: Angela Martin‐Serrano, Ezequiel Perez‐Inestrosa, Cristobalina Mayorga, María José Torres, Maria Isabel Montañez
Journal: Allergy (2020)

The authors declare no other relevant conflicts of interest. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Association of Neighborhood Deprivation Index With Success in Cancer Care Crowdfunding
Authors: Elisabeth R. Silver, Han Q. Truong, Sassan Ostvar, Chin Hur, Nicholas P. Tatonetti
Journal: JAMA Network Open (2020)

<h3>Importance</h3> Financial toxicity resulting from cancer care poses a substantial public health concern, leading some patients to turn to online crowdfunding. However, the practice may exacerbate existing socioeconomic cancer disparities by privileging those with access to interpersonal wealth and digital media literacy. <h3>Objective</h3> To test the hypotheses that higher county-level socioeconomic status and the presence (vs absence) of text indicators of beneficiary worth in campaign descriptions are associated with amount raised from cancer crowdfunding. <h3>Design, Setting, and Participants</h3> This cross-sectional analysis examined US cancer crowdfunding campaigns conducted between 2010 and 2019 and data from the American Community Survey (2013-2017). Data analysis was performed from December 2019 to March 2020. <h3>Exposures</h3> Neighborhood deprivation index of campaign location and campaign text features indicating the beneficiary’s worth. <h3>Main Outcomes and Measures</h3> Amount of money raised. <h3>Results</h3> This study analyzed 144 061 US cancer crowdfunding campaigns. Campaigns in counties with higher neighborhood deprivation raised less (–26.07%; 95% CI, –27.46% to –24.65%;<i>P</i> &lt; .001) than those in counties with less neighborhood deprivation. Campaigns raised more funds when legitimizing details were provided, including clinical details about the cancer type (9.58%; 95% CI, 8.00% to 11.18%;<i>P</i> &lt; .001) and treatment type (6.58%; 95% CI, 5.44% to 7.79%;<i>P</i> &lt; .001) and financial details, such as insurance status (1.39%; 95% CI, 0.20% to 2.63%;<i>P</i> = .02) and out-of-pocket costs (7.36%; 95% CI, 6.18% to 8.55%;<i>P</i> &lt; .001). Campaigns raised more money when beneficiaries were described as warm (13.80%; 95% CI, 12.30% to 15.26%;<i>P</i> &lt; .001), brave (15.40%; 95% CI, 14.11% to 16.65%;<i>P</i> &lt; .001), or self-reliant (5.23%; 95% CI, 3.77% to 6.72%;<i>P</i> &lt; .001). <h3>Conclusions and Relevance</h3> These findings suggest that cancer crowdfunding success ay disproportionately benefit those in high–socioeconomic status areas and those with the internet literacy necessary to portray beneficiaries as worthy. By rewarding those with existing socioeconomic advantage, cancer crowdfunding may perpetuate socioeconomic disparities in cancer care access. The findings also underscore the widespread nature of financial toxicity resulting from cancer care.
Two doctors are restored to the medical register, matching total for 2019
Authors: Clare Dyer
Journal: BMJ (2020)

Two doctors who were struck off the UK medical register years ago have been restored in successive days, matching the total for all of 2019. The pace of restorations has accelerated during the covid-19 pandemic.

Last year two applications were granted and 11 refused. So far in 2020 the Medical Practitioners Tribunal Service has heard 17 applications for restoration, of which seven were granted.

Mostafa Karam Sorour Mahmoud won restoration in a hearing that was held in private, a common practice when questions of medical confidentiality are involved. Mahmoud worked for St Helens and Knowsley Teaching Hospitals NHS Trust and was struck off in 2013 for unknown disciplinary reasons. Details of the case will be …
<i>SRP54</i>mutations induce congenital neutropenia via dominant-negative effects on<i>XBP1</i>splicing
Authors: Christoph Schürch, Thorsten Schaefer, Joëlle S. Müller, Pauline Hanns, Marlon Arnone, Alain Dumlin, Jonas Schärer, Irmgard Sinning, Klemens Wild, Julia Skokowa, Karl Welte, Raphael Carapito, Seiamak Bahram, Martina Konantz, Claudia Lengerke
Journal: Blood (2020)
The effect of different coatings on bone response and degradation behavior of porous magnesium-strontium devices in segmental defect regeneration
Authors: Nan Zhang, Weidan Wang, Xiuzhi Zhang, Krishna. C. Nune, Ying Zhao, Na Liu, R.D.K. Misra, Ke Yang, Lili Tan, Jinglong Yan
Journal: Bioactive Materials (2020)

Regeneration of long-bone segmental defects remains a challenge for orthopedic surgery. Current treatment options often require several revision procedures to maintain acceptable alignment and achieve osseous healing. A novel hollow tubular system utilizing magnesium-strontium (Mg-Sr) alloy with autogenous morselized bone filled inside to repair segmental defects was developed. To improve the corrosion and biocompatible properties, two coatings, Ca-P and Sr-P coatings, were prepared on surface of the implants. Feasibility of applying these coated implants was systematically evaluated
地方のウガンダとケニアのコミュニティにおけるHIV RNAの個体群レベルと地理的分布,抗体検査結果が異なるカップルを含む:横断的解析【Powered by NICT】
Authors: Jain Vivek, Petersen Maya L, Liegler Teri, Byonanebye Dathan M, Kwarisiima Dalsone, Chamie Gabriel, Sang Norton, Black Doug, Clark Tamara D, Ladai Andras, Plenty Albert, Kabami Jane, Ssemmondo Emmanuel, Bukusi Elizabeth A, Cohen Craig R, Charlebois Edwin D, Kamya Moses R, Havlir Diane
Journal: The Lancet HIV (2017)
15938 Tildrakizumab efficacy by metabolic syndrome status in psoriasis: Post hoc analysis of 3-year data from the phase 3 reSURFACE 1 study
Authors: Mark G. Lebwohl, Alice B. Gottlieb, Alan M. Mendelsohn, Jeff Parno, Stephen J. Rozzo, Martin Menter
Journal: Journal of the American Academy of Dermatology (2020)
Homo-PROTAC mediated suicide of MDM2 to treat non-small cell lung cancer
Authors: Shipeng He, Junhui Ma, Yuxin Fang, Ying Liu, Shanchao Wu, Guoqiang Dong, Wei Wang, Chunquan Sheng
Journal: Acta Pharmaceutica Sinica B (2020)

The dose-related adverse effects of MDM2‒P53 inhibitors have caused significant concern in the development of clinical safe anticancer agents. Herein we report an unprecedented homo-PROTAC strategy for more effective disruption of MDM2‒P53 interaction. The design concept is inspired by the capacity of sub-stoichiometric catalytic PROTACs enabling to degrade an unwanted protein and the dual functions of MDM2 as an E3 ubiquitin ligase and a binding protein with tumor suppressor P53. The new homo-PROTACs are designed to induce self-degradation of MDM2. The results of the investigation have shown that PROTAC 11a efficiently dimerizes MDM2 with highly competitive binding activity and induces proteasome-dependent self-degradation of MDM2 in A549 non-small cell lung cancer cells. Furthermore, markedly, enantiomer 11a-1 exhibits potent in vivo antitumor activity in A549 xenograft nude mouse model, which is the first example of homo-PROTAC with in vivo therapeutic potency. This study demonstrates the potential of the homo-PROTAC as an alternative chemical tool for tumorigenic MDM2 knockdown, which could be developed into a safe therapy for cancer treatment.