tbuckley/cabot-search huggingface dataset:
Myocardial relaxation and passive diastolic properties in man.
Authors: APasipoularides, IMirsky, O MHess, JGrimm, H PKrayenbuehl
Journal: Circulation (1986)

We have developed a model for assessing the influence of the decaying contractile systolic tension on diastolic wall dynamics and the passive properties of left ventricular muscle. Total measured left ventricular diastolic pressure and stress (sigma T) are determined by two overlapping processes: the decay of actively developed pressure and stress (sigma A) and the buildup of passive filling pressure and stress (sigma*). The decaying contractile stress sigma A is formulated in terms of a relaxation pressure with a time constant (T) assessed during the isovolumic relaxation interval. By subtracting the contribution of sigma A from sigma T we obtain sigma*. With micromanometry, echocardiography, and cineangiography, total and passive stress-strain relations and strain rates were evaluated over the entire filling period in six normal control subjects and in seven patients with aortic stenosis. Elastic stiffness constants (k), the slopes of the linear passive stiffness vs sigma* relations, did not differ in t...
Possible Subclinical Leaflet Thrombosis in Bioprosthetic Aortic Valves
Authors: Hoda Hatoum, Juan A Crestanello, Lakshmi P Dasi
Journal: New England Journal of Medicine (2016)

To the Editor: Makkar et al. (Nov.19 issue) 1 report possible subclinical leaflet thrombosis in up to 40% of patients involved in a clinical trial of transcatheter aortic-valve replacement (TAVR).In contrast, we found a relatively low incidence (7%) of possible subclinical valve leaflet thrombosis among patients in our series in which 255 patients underwent TAVR with the use of a CoreValve prosthesis.A retrospective review of our series (unpublished data) showed that in 104 patients, cardiac computed tomography (CT) at a median of 7 days after implantation (range, 3 to 87) (in 51 patients), transesophageal echocardiography at a median of 45 days (range, 7 to 421) after implantation (in 76 patients), or both (in 23 patients) was performed.In 101 patients, the findings were deemed to be interpretable.Of these patients, 52% were receiving dual antiplatelet therapy, 19% aspirin or thienopyridine monotherapy, and 29% oral anticoagulation.A definite thrombus was identified in three patients (3%; one patient each on days 31, 44, and 87 after implantation).All three patients were receiving continuous dual antiplatelet therapy.An additional four patients (4%) had hypoattenuated leaflet thickening (two patients on day 7 after implantation and one patient each on days 8 and 47 after implantation).We hypothesize that besides the antithrombotic strategy, the valve type (bovine vs. porcine) and design (intraannular vs. supraannular) might also be related to the occurrence of thrombosis, at least in selfexpandable nitinol frames.
Effects of alcohol use and other aspects of lifestyle on blood pressure levels and prevalence of hypertension in a working population.
Authors: P DArkwright, L JBeilin, IRouse, B KArmstrong, RVandongen
Journal: Circulation (1982)

The relationship between alcohol consumption and blood pressure was studied in 491 males, ages 20-45 years, who volunteered to complete a health questionnaire and submit to standardized measurements of blood pressure, heart rate and body size. Average weekly alcohol consumption correlated with systolic pressure (r = 0.18) but not diastolic pressure. Systolic pressure increased progressively with increasing alcohol consumption, with no obvious threshold effect. In moderate and heavy drinkers (53% of the population studied), the prevalence of systolic hypertension (greater than or equal to 140 mm Hg) was four times that of teetotalers. The effect of alcohol on systolic blood pressure was independent of the effects of age, obesity, cigarette smoking and physical activity. Ex-heavy drinkers had blood pressures similar to those of teetotalers, suggesting that the effect of alcohol is reversible. Cigarette smokers had lower diastolic pressures than nonsmokers, an effect independent of obesity. The linear correl...
Admissions integrity preserved
Authors: T. S. Garden
Journal: JAMA (1978)

The recent threat to the integrity of the medical school admissions process posed by the US Congress has eased, temporarily at least, with the passage of a bill that all but rescinds an earlier legislative edict that attempted to force acceptance of transfer students from foreign medical schools. The original law, passed last year, had been contested vigorously by the medical schools, 14 of which were willing to forfeit substantial federal assistance rather than accept such transfer students. Other schools in more precarious financial straits were faced with the decision of compromising their integrity or being overwhelmed by their creditors. In passing the original law, Congress was responding to numerous pressures, the most prominent coming from the parents and friends of American students studying in foreign medical schools with the hope of returning home to conclude their studies and enter practice. The proposal also seemed like an easy way to
Left ventricular diastolic function. Doppler echocardiographic changes soon after cardiac transplantation.
Authors: F GStGoar, RGibbons, ISchnittger, H AValantine, R LPopp
Journal: Circulation (1990)

In acute cardiac rejection, left ventricular diastolic function is altered, and a restrictive ventricular filling pattern occurs. Doppler echocardiographic indexes of mitral inflow have been proposed as sensitive markers of the rejection process. As rejection progresses, the restrictive ventricular filling pattern is reflected by a shortening of isovolumic relaxation time and mitral valve pressure half-time and by an increase in early transmitral filling velocity. Diastolic function is also compromised in the nonrejecting cardiac transplant recipient during the early postoperative period. This study examined the progression in Doppler-derived mitral filling indexes in 25 recent cardiac transplant recipients who demonstrated no histological evidence of transplant rejection. Isovolumic relaxation time, mitral valve pressure half-time, and early transmitral filling velocity were measured at postoperative weeks 1, 2, 4, and 6 on the day that surveillance right ventricular endomyocardial biopsies were performe...
Safety, pharmacokinetics, and antitumor activity of MEDI3617, a selective angiopoietin inhibitor, in adult patients with advanced solid tumors.
Authors: Ronald B. Natale, Naiyer A. Rizvi, Jeffrey R. Infante, Lindsay J. Joseph, Jaye Viner, Jennifer T. McDevitt, Fei Ji, Soyoung Shin, Meina Liang, Howard A. Burris
Journal: Journal of Clinical Oncology (2012)

TPS2621 Background: MEDI3617 is an investigational monoclonal antibody that inhibits angiogenesis by preventing the interaction of angiopoietin-1 and angiopoietin-2 (Ang2) ligands with the Tie2 receptor. Methods: This is an ongoing phase 1 dose-escalation and dose-expansion study in patients with advanced solid tumors, Karnofsky performance status ≥70, and adequate organ function. Patients were treated with escalating IV doses of MEDI3617 on day 1 of each 21 day cycle in cohorts of 3-6 patients. The objectives are to evaluate the safety profile and determine the maximum tolerated dose, dose-limiting toxicities (DLT), pharmacokinetics, pharmacodynamics, and clinical activity of MEDI3617. Results: Preliminary data are presented for 21 patients (14M/7F), median age 65 yrs, evaluable for DLT. One DLT occurred: grade 4 neutropenia lasting more than 7 days. The most frequently reported drug-related adverse events (% of patients) were fatigue (24%), diarrhea (19%), nausea (19%), dysgeusia (14%), and headache (14%), all of which were ≤ grade 2. All monotherapy dose levels have completely enrolled patients without exceeding the maximum tolerated dose. The exposure of MEDI3617 after the first dose showed a more than dose-proportional increase. Suppression of free Ang2 was dose-dependent. Maximum accumulation of total Ang2 was observed at the lowest administered dose. No anti-MEDI3617 neutralizing antibodies were detected. Of the 21 patients, 4 continue on treatment (maximum of 6+ months in a patient with carcinoid tumor of the jejunum) as of the data cut-off date. Of the 17 patients for whom response data are available, 5 had stabilization of disease of 12 weeks or greater. Conclusions: Preliminary safety and activity signals warrant continued evaluation of MEDI3617. This study was funded by MedImmune, LLC.
Low molecular weight heparin in prevention of restenosis after angioplasty. Results of Enoxaparin Restenosis (ERA) Trial.
Authors: D PFaxon, T ESpiro, SMinor, GCoté, JDouglas, RGottlieb, RCaliff, KDorosti, ETopol, J BGordon
Journal: Circulation (1994)

BACKGROUNDHeparin, an anticoagulant, possesses antiproliferative effects and has been shown to reduce neointimal proliferation and restenosis following vascular injury in experimental studies.METHODS AND RESULTSThe primary aim of this double-blind multicenter study was to determine if 40 mg Enoxaparin, a low molecular weight heparin, administered subcutaneously once daily for 1 month after successful angioplasty would reduce the incidence of restenosis. Four hundred fifty-eight patients were randomized at nine clinical centers (231 to placebo and 227 to Enoxaparin). The primary end point was angiographic or clinical restenosis. Angiographic restenosis was defined as a loss of 50% of the initial gain as measured by quantitative coronary angiography (QCA) at a core laboratory. In the absence of QCA, clinical evidence of restenosis was defined as death, myocardial infarction, repeat revascularization, or worsening angina. Using the intention-to-treat analysis for all patients, restenosis occurred in 51% of t...
Delayed PET/CT of Pericardial Synovial Sarcoma
Authors: Antonella Stefanelli, Giordano Savelli, Mattia Bonacina, Alberto Zaniboni
Journal: Clinical Nuclear Medicine (2021)

Abstract Pericardial synovial sarcoma is a rare malignancy. We report the case of a patient who was referred to our institution for a large pericardial effusion requiring pericardiocentesis. CT imaging revealed an inhomogeneous pericardial mass beside the right atrium, and then a PET/CT scan was performed. Standard images were inconclusive whether delayed images showed an FDG-avid pericardial lesion that was surgically removed with histological diagnosis of a poorly differentiated biphasic synovial sarcoma. When considering mediastinal or pericardial mass, a delayed PET/CT may improve lesion-to-background contrast by reducing blood pool activity.
Oscillometric devices are good in routine practice
Authors: Nelson
Journal: BMJ (2011)

Myers and colleagues show that blood pressure recording is better with an automated than a conventional device when multiple recordings are taken in an isolated room.1 However, as Mant and McManus point out, The six readings taken two minutes apart as used in the study will be practically difficult to implement in many primary care settings.2 Space is also a concern in primary care. 

Our earlier cluster randomised controlled trial comparing oscillometric and manual sphygmomanometry for blood pressure management in Australian primary care (24 practices and 824 unselected visits with blood pressure recording) found better recording and management in the oscillometric practices.3 Oscillometric devices can be recommended in primary care even without the additional recommended changes to eliminate white coat effects.
In vivo demonstration of cardiac beta 2-adrenoreceptor sensitization by beta 1-antagonist treatment.
Authors: J AHall, M CPetch, M JBrown
Journal: Circulation Research (1991)

Treatment with beta 1-selective antagonists causes selective sensitization of isolated strips of human atrial myocardium to the inotropic action of epinephrine and beta 2-agonists but not of norepinephrine. To determine whether beta 1-selective antagonist treatment alters the responsiveness of cardiac beta 2-adrenoreceptors in vivo, we measured the positive chronotropic responses to salbutamol injected into the right coronary artery. Ten patients treated with atenolol (50-100 mg daily) were compared with 10 patients not treated with beta-blockers. The mean dose required to cause an increase in heart rate of 30 beats/min was 2.29 micrograms (log dose 0.36 +/- 0.12 micrograms [mean +/- SEM]) in the atenolol-treated patients. In the non-beta-blocker-treated patients, the dose required to cause an increase in heart rate of 30 beats/min was significantly greater, 8.91 micrograms (log dose 0.95 +/- 0.11 micrograms) (p less than 0.005). We conclude that treatment with beta 1-selective beta-blockers leads to incr...
Quantitative comparison of the force-interval relationships of the canine right and left ventricles.
Authors: DBurkhoff, D TYue, M RFranz, W CHunter, KSunagawa, W LMaughan, KSagawa
Journal: Circulation Research (1984)

We quantitatively compared the extrasystolic and postextrasystolic responses of the right ventricle and left ventricle of the same heart, which have vastly different geometries, architectures, and muscle masses. We studied nine isolated, supported canine hearts whose right and left ventricles were made to contract isovolumically with balloons placed in both chambers. The ventricles were paced with the following pattern: 20 regularly timed priming stimulations, followed by a test stimulation at a variable test pulse interval, and, finally, by a second test stimulation which was always delivered 1200 msec after the first test pulse. In each heart, approximately 15 different test pulse intervals between 300 and 1200 msec were investigated. Both the maximum developed pressure and maximum rate of pressure development, expressed as a percentage of their steady state values during the priming period were used to quantify the extra- and postextrasystolic responses. For each extrasystolic and postextrasystolic tes...
Number of Passes and Lymph Node Size Predict Adequate Yield of Tissue in Absence of on-Site Evaluation During EUS Guided Sampling
Authors: S Harindranath, S Sundaram, A Kale, A Singh, A Shukla
Journal: Endoscopy (2021)

Aims Endoscopic ultrasound (EUS) sampling is a vital step in diagnosis of abdominal and mediastinal lymphadenopathy. We performed a retrospective study to study accuracy of EUS guided tissue sampling of lymphadenopathy in absence of On-Site Evaluation (OSE) by cyto-pathologist and predictive factors leading to inadequate sampling.
Oxygen-dependent tension in vascular smooth muscle. Does the endothelium play a role?
Authors: R FCoburn, REppinger, D PScott
Journal: Circulation Research (1986)

We investigated a hypothesis that an oxygen sensor involved in hypoxia-induced relaxation of vascular smooth muscle may reside in endothelial cells. We also determined the oxygen dependence of hypoxia-induced decreases in cyclic guanosine 3',5'-monophosphate concentrations in vascular smooth muscle rings. Rings of canine femoral artery, rabbit thoracic aorta, and lamb ductus arteriosus, either with an intact endothelium or with damaged or absent endothelium, were studied using organ baths that allowed changes in PO2 without a change in pH. Hypoxia-induced relaxations of rabbit thoracic aorta, lamb ductus arteriosus, and canine femoral artery were not dependent on an intact endothelium. The magnitude of hypoxia-induced relaxations was unchanged in rings of canine femoral artery without intact endothelium compared to rings with endothelium. Quasi-steady state organ bath PO2-mechanical tension relationships were unchanged in rings of canine femoral artery without endothelium over an organ PO2 range of 200-20...
Skin Disease from colour developers.
Authors: P. de Graciansky
Journal: British Journal of Dermatology (1966)

Journal Article Skin Disease from colour developers. Get access P. de Graciansky P. de Graciansky Hôpital Saint‐Louis, Place du Docteur Fournier, Paris Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 78, Issue 5, 1 May 1966, Pages 297–298, https://doi.org/10.1111/j.1365-2133.1966.tb12226.x Published: 01 May 1966
Marked reduction of free radical generation and contractile dysfunction by antioxidant therapy begun at the time of reperfusion. Evidence that myocardial "stunning" is a manifestation of reperfusion injury.
Authors: RBolli, M OJeroudi, B SPatel, O IAruoma, BHalliwell, E KLai, P BMcCay
Journal: Circulation Research (1989)

Recent evidence suggests that postischemic myocardial dysfunction (stunning) may be mediated by oxygen free radicals, but the exact time window during which the critical radical-mediated damage develops remains unknown. Furthermore, the evidence for the oxyradical hypothesis is indirect and, therefore, inconclusive. Thus, the potent and cell-permeable antioxidant N-(2-mercaptopropionyl)-glycine (MPG) was administered as an intra-coronary infusion (8 mg/kg/hr) to three groups of open-chest dogs undergoing a 15-minute coronary occlusion followed by 4 hours of reperfusion. In group I (n = 8), the infusion of MPG was started 15 minutes before occlusion and ended 2 hours after reperfusion; in group II (n = 9), MPG was started 1 minute before reperfusion and ended 2 hours thereafter; in group III (n = 10), MPG was started 1 minute after reperfusion and ended 2 hours and 15 minutes thereafter. Control dogs (group IV) (n = 10) received vehicle. Recovery of contractile function (assessed as systolic wall thicken...
Shall The Journal be Removed to Washington?
Authors: W. L. Schenck
Journal: JAMA (1891)

<h3>To the Editor:</h3> —Why shouldThe Journalgo to Washington? The question is full of suggestion. Why should it have been established at Chicago? Clearly because it was a convenient centre, with no East and no West, whence it could most speedily communicate with all points. Has it ceased to be our great central metropolis? Then Congress made a mistake in locating the world's greatest exposition. Are paper, and ink, and printing presses no longer at its command, or are mailing facilities unequal to its demands, or have all the brains of the Nation gravitated to its Eastern slope? We grant "the sun rises in the East to open and illume the day," but she travels westward, and at high noon is its beauty and glory. Whilst Chicago will long remain the central metropolis of America and the most convenient home for its great medical journal, no one section, no
Changes in blood rheology in patients with stable angina pectoris as a result of coronary artery disease.
Authors: CRainer, D TKawanishi, P AChandraratna, R MBauersachs, C LReid, S HRahimtoola, H JMeiselman
Journal: Circulation (1987)

We investigated several rheologic variables in 17 patients (11 men, six women, mean age = 52.1 +/- 9.8 years) with chronic stable angina. None took any medication except for sublingual nitroglycerin for 2 weeks before the study, and all had angiographically proven coronary artery disease with no history of myocardial infarction. Rheologic measurements included hematocrit, whole blood and plasma viscosity (750 and 1500 sec-1), degree of red cell aggregation via the zeta sedimentation ratio, and the extent and rate of red cell aggregation after stasis (Myrenne aggregometer). Compared with normal control donors, salient observations in the patients as a group included: a small (6%) but significant increase in hematocrit, a significant elevation in plasma viscosity (9%), significant increases in whole blood viscosity at both shear rates (14% and 16%), significant increases in the degree (12%), the extent (41%), and the rate (28% faster time constant) of red cell aggregation, an elevated alpha 2 level (15% inc...
Fast-Fourier transform analysis of signal-averaged electrocardiograms for identification of patients prone to sustained ventricular tachycardia.
Authors: M ECain, H DAmbos, F XWitkowski, B ESobel
Journal: Circulation (1984)

Electrocardiograms obtained from patients during arrhythmia-free intervals do not identify those prone to sustained ventricular tachycardia (VT) despite the occult delayed activation that is presumably present. To determine whether frequency-domain analysis facilitates detection of this hallmark of predisposition to VT, fast-Fourier transform analysis (FFTA) procedures were developed and tested with a computer-generated mathematical model. The FFTA approach developed allows inherent limitations of high-gain amplification and a priori filtering used commonly for time-domain analysis to be avoided. After demonstrating that FFTA detected low-amplitude oscillatory waveforms in signal-averaged recordings in the frequency domain, the procedure was applied to signal-averaged X, Y, and Z lead recordings from the following three groups of patients: group I, patients with prior myocardial infarction and episodic sustained VT (n = 16); group II, patients with prior myocardial infarction without overt sustained VT (n...
Nonsynchronous accumulation of alpha-skeletal actin and beta-myosin heavy chain mRNAs during early stages of pressure-overload--induced cardiac hypertrophy demonstrated by in situ hybridization.
Authors: SSchiaffino, J LSamuel, DSassoon, A MLompré, IGarner, FMarotte, MBuckingham, LRappaport, KSchwartz
Journal: Circulation Research (1989)

The development of cardiac hypertrophy secondary to pressure overload is accompanied by isoformic changes of contractile proteins such as myosin and actin. 35S-Labeled complementary RNA (cRNA) probes and in situ hybridization procedures were used for analysis of the regional distribution of newly formed transcripts from alpha-skeletal actin (alpha-sk-actin) and beta-myosin heavy chain (beta-MHC) genes during the early stages of pressure overload. The study was performed in 25-day-old rats submitted to a thoracic aortic stenosis and killed after surgery at times ranging from 4 hours to 3 days. Neither alpha-sk-actin nor beta-MHC messenger RNA (mRNA) was detected in the hearts of normal and sham-operated animals. However, alpha-sk-actin mRNA accumulated throughout the entire left ventricle as early as 4 hours after aortic stenosis, and by 12 hours was also detected in the left atrium. In contrast, beta-MHC mRNA was hardly detectable before day 1, and by days 2-3 was mainly restricted to the inner part of th...
Association of Race With Lung Cancer Risk Among Adults Undergoing Lung Cancer Screening
Authors: Christine S. Shusted, Nathaniel R. Evans, Hee-Soon Juon, Gregory C. Kane, Julie A. Barta
Journal: JAMA Network Open (2021)

This cross-sectional study examines whether race is associated with differences in 6-year lung cancer risk among patients eligible for US Preventive Services Task Force–recommended lung cancer screening.
Decreased magnitude of heart rate spectral components in coronary artery disease. Its relation to angiographic severity.
Authors: JHayano, YSakakibara, MYamada, NOhte, TFujinami, KYokoyama, YWatanabe, KTakata
Journal: Circulation (1990)

We analyzed the spectral components of RR interval variability under controlled respiration (15 breaths/min) in 56 patients (age range, 35-73 years) referred for coronary angiography; 14 patients had multivessel disease (group M), 21 had one-vessel disease (group S), and 21 had nonsignificant disease or normal coronary artery (group N). There were 43 healthy controls (age range, 36-71 years) (group C). The patients had no clinical evidence of heart failure, hypertension, diabetes mellitus, or acute stage of infarction and had taken no medication for 3 days. The autoregressive power spectral density of RR interval variability contains two major components, respiratory sinus arrhythmia (RSA) (0.25 Hz) and Mayer wave-like sinus arrhythmia (MWSA) (0.04-0.15 Hz), which have magnitudes that are quantitative markers of cardiac vagal activity and sympathetic activity with vagal modulation, respectively. We represented the magnitudes by the coefficient of component variance (CCV), which provided the amplitude rela...