tbuckley/cabot-search huggingface dataset:
Aerobic Exercise and Resting Blood Pressure in Older Adults: A Meta-Analytic Review of Randomized Controlled Trials
Authors: George A. Kelley, Kristi S. Kelley
Journal: Circulation (2001)

P98 OBJECTIVE: Use the meta-analytic approach to examine the effects of aerobic exercise on resting systolic and diastolic blood pressure in older adults. METHODS: Studies were retrieved from (1) computer searches (MEDLINE, Current Contents, Sport Discus), (2) cross-referencing from bibliographies of retrieved studies and review articles, and (3) expert review of reference list. Inclusion criteria for this study were (1) randomized trials, (2) aerobic activity as the only intervention, (3) nonexercise control group included, (4) changes in resting systolic and/or diastolic blood pressure assessed, (5) within study ages of subjects ≥ 50 years, (6) English-language studies published in journals between January 1966 and January 1998. All studies were coded by both authors, independent of each other. The authors then met and reviewed every item coded. Discrepancies were resolved by consensus. Net changes in blood pressure were calculated as the exercise minus control group difference. RESULTS: A total of 14 primary outcomes were derived from 7 studies. Using a random-effects model, decreases of approximately 2% and 1% were found for resting systolic and diastolic blood pressure, respectively, with only changes in systolic blood pressure statistically significant (systolic, mean ± SD = -2 ± 3 mmHg, 95% confidence interval = -4 to -1; diastolic, mean ± SD = -1 ± 2 mmHg, 95% confidence interval = -2 to 0 mmHg). No statistically significant publication bias was observed for changes in either resting systolic or diastolic blood pressure. Regression analyses revealed a statistically significant association between changes in resting systolic blood pressure and initial systolic blood pressure (R = 0.73, SEE = 0.57, p = 0.003). Changes in blood pressure were independent of changes in body weight, body fat, and body mass index. CONCLUSIONS: Aerobic exercise is efficacious for reducing resting systolic blood pressure in older adults. However, a need exists for additional studies that address the effectiveness of this intervention for reducing resting blood pressure in older adults.
International Symposium on Medical Radionuclide Imaging
Journal: JNCI Journal of the National Cancer Institute (1979)

International Symposium on Medical Radionuclide Imaging Get access JNCI: Journal of the National Cancer Institute, Volume 63, Issue 4, October 1979, Page 1105, https://doi.org/10.1093/jnci/63.4.1105-d Published: 01 October 1979
MIR-223 IS SUPPRESSED IN EXOSOMES OF PATIENTS WITH HIGH-RISK MYELODYSPLASTIC SYNDROMES AND MAY BE A MARKER OF RESIDUAL GRANULOCYTIC-MONOCYTIC DIFFERENTIATION
Authors: B. Benites, A. Duarte, M. Alvarez, I. Santos, L. Ribeiro, E. de Paula, S. Saad
Journal: HemaSphere (2019)
Poziotinib Shows Promise for Rare Lung Cancer
Journal: Cancer Discovery (2017)

Abstract Poziotinib, an EGFR inhibitor that was previously shelved as ineffective against non–small cell lung cancer, is showing promising activity in a subset of patients with EGFR exon 20 insertions. According to preliminary data from a phase II trial, the drug led to a 73% overall response rate in patients with this disease subtype, which is typically highly resistant to standard therapy.
Biochimica et Biophysica Acta, Amsterdam
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cancer Outcomes
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
临床上无肌病性皮肌炎的治疗
Authors: J. Callander, Y. Robson, J. Ingram, V. Piguet
Journal: British Journal of Dermatology (2018)

皮肌炎是一种不寻常的自体免疫疾病(其中身体的免疫系统不能正常运作),而典型的皮疹与肌肉炎症有关。然而,有些患者患有与肌肉疾病无关的皮肤病,这就是所谓的无肌病性皮肌炎,而且对于治疗这些患者的最佳方法并没有定论。来自威尔士加的夫的作者回顾了关于无肌病性皮肌炎患者治疗的文献。他们确定了 18 个病例系列(来自不止一名患者的信息)和 42 个病例报告(来自一名患者的信息),但没有随机对照试验,而它们是研究的黄金标准。抗疟药(如羟氯喹)曾是最常用的药物,但在 55% 的患者中无效。其他药物包括局部和全身性皮质激素、甲氨蝶呤、氨苯砜、霉酚酸酯和局部他克莫司。静脉注射免疫球蛋白可以改善甚至缓解大多数皮肤肌炎患者,不论是否涉及肌肉。作者强调需要更有力、更公正的研究来评估这种情况下的治疗效果。
Colchicine Antimitosis Abolishes Resiliency of Postnatally Developing Rats to Chlordecone-Amplified Carbon Tetrachloride Hepatotoxicity and Lethality
Authors: Abraham Dalu, Prathibha S. Rao, Harihara M. Mehendale
Journal: Environmental Health Perspectives (1998)

We have previously reported that rats are resilient to the hepatotoxic and lethal combination of chlordecone (CD) and carbon tetrachloride (CCl4) during early postnatal development. The overall findings pointed to stimulated cell division and tissue repair mechanisms as the underlying cause of resistance. The objective of the current study was to investigate if the antimitotic effect of colchicine (CLC) abolishes this resiliency to CD + CCl4 by inhibiting ongoing and stimulated cell division. We used 45-day-old rats in this study because this age group exhibited partial sensitivity to CD + CCl4 in our previous studies. Male Sprague-Dawley rats were treated with a single low intraperitoneal dose of CCl4 (100 microl/kg) or corn oil after exposure to either 10 ppm CD in the diet or a normal diet (ND) for 15 days. CLC (1 mg/kg) was administered 6 or 30 hr after CCl4 to ND or CD rats, respectively. Administration of CLC resulted in increased CCl4-induced mortality from 25% to 85% in rats pretreated with CD, in contrast to 100% survival in ND rats. Liver injury was assessed by plasma alanine transaminase (ALT) and sorbitol dehydrogenase (SDH) elevations as well as by histopathology. Hepatocellular regeneration was assessed by 3H-thymidine (3H-T) incorporation into hepatonuclear DNA and proliferating cell nuclear antigen (PCNA) studies during 0-96 hr after CCl4. Administration of CLC to ND + CCl4 rats resulted in a slight delay in cell division and tissue repair, as indicated by 3H-T incorporation and PCNA, thereby leading to prolonged liver injury as revealed by elevations in plasma ALT, SDH, and histopathological lesions. In contrast, CLC administration to CD + CCl4-treated rats further delayed and diminished cell division by 80%, which led to unrestrained progression of CCl4-induced liver injury, resulting in 85% mortality. These findings underscore the importance of ongoing and toxicant-stimulated cell division and tissue repair mechanisms in hepatotoxicity, and the need for the inclusion of age factors in risk assessment of exposure to environmental and other chemicals.
Our Debt to Sir John McMichael
Authors: E. J. H.
Journal: Annals of Internal Medicine (1968)

Editorial Notes1 May 1968Our Debt to Sir John McMichaelE. J. H.E. J. H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1133 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAmerican Medical Science owes much of its style to the physiological attack on clinical problems so characteristic of the best of British and Scandinavian medicine. And it owes much of its vigor to those investigators trained in that setting who subsequently came to our medical schools and institutes. Both of these contributions from abroad are illustrated in the January 1968 issue of Postgraduate Medical Journal, a Festschrift for Sir John McMichael, formerly Director of the Department of Medicine, Postgraduate Medical School of London, and now Director of the British Postgraduate Medical Federation.Dr. McMichael is, himself, an exemplar of the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1133-1133 ePublished: 1 December 2008 Issue Published: 1 May 1968 PDF downloadLoading ...
Cost and Effectiveness of Hepatitis B Immunization
Authors: Bernard S. Bloom
Journal: Annals of Internal Medicine (1993)

Letters15 September 1993Cost and Effectiveness of Hepatitis B ImmunizationBernard S. Bloom, MD, Alan J. Hillman, MD, A. Mark Fendrick, MD, and J. Sanford Schwartz, MDBernard S. Bloom, MDSearch for more papers by this author, Alan J. Hillman, MDSearch for more papers by this author, A. Mark Fendrick, MDSearch for more papers by this author, and J. Sanford Schwartz, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-6-199309150-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree with Dr. Asch that we probably underestimated the cost-effectiveness of hepatitis B virus vaccination by not incorporating the effects of herd immunity in our analysis [1]. We also agree that quantifying the effects of herd immunity is extremely difficult when examining any vaccination strategy. Our study evaluated three strategies (universal vaccination, screening and vaccination of those with negative test results, no vaccination) in four populations (newborns, adolescents, general adults, high-risk adults).We took conservative positions wherever possible; that is, we purposely underestimated benefits and increased costs, thereby reducing cost-effectiveness ratios of all vaccination strategies examined. We ...References1. Bloom BS, Hillman AL, Fendrick AM, Schwartz JS. A reappraisal of hepatitis B virus vaccination using cost-effectiveness analysis. Ann Intern Med. 1993; 118:298-306. Google Scholar2. Hillman AL, Eisenberg JM, Pauly MV, Bloom BS, Glick H, Kinosian B, et al. Avoiding bias in the conduct of cost-effectiveness research sponsored by pharmaceutical companies. N Engl J Med. 1991; 324: 1362-5. Google Scholar Author, Article, and Disclosure InformationAuthors: Bernard S. Bloom, MD; Alan J. Hillman, MD; A. Mark Fendrick, MD; J. Sanford Schwartz, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 September 1993Volume 119, Issue 6 Page: 536-537 Keywords Adolescents Adults Children Hepatitis B Hepatitis B virus Immunity Population statistics ePublished: 15 August 2000 Issue Published: 15 September 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Childhood bereavement.
Journal: BMJ (1967)

Hong Kong, found duration and severity of paralysis unrelated to toxicity and suggest that basic defect may be genetically determined (p. 451).Respiratory Disease: Professor N. R. Grist and colleagues found that influenza in adults and respiratory syncytial virus infections in children were important causes of pneumonia (p.456).Dr. T. Feizi and colleagues report an outbreak of acute respiratory disease in Scotland due to M. pneumoniae (p.457).Thymectomy in Autoimmune Disease: Dr. J. A. Milne and colleagues report no improve- ment after thymectomy in three cases of systemic lupus erythematosus and two cases of rheu- matoid arthritis resistant to therapy (p.461).Behget's Syndrome: Dr. T. Lehner suggests two aetiologically distinguishable groups (p.465).Gangrene in Infants: Dr. Anne Lloyd and col- leagues report four infants with gangrene of the extremities due to polyarteritis nodosa treated with immunosuppressants (p.468).
Bias estimates of mortality using MedisGroups
Journal: JAMA (1991)

<h3>To the Editor.</h3> —Dr Blumberg<sup>1</sup>recently described "bias" in the 1987 MedisGroups admission severity score. One conclusion was that severity is not a sufficient adjuster for interhospital comparisons. We studied three factors discussed by Blumberg using the 1991 MedisGroups system. Our study confirms the results of his analysis relative to the presence of bias, but suggests that bias does not have a practical effect on interhospital comparisons for two of the three factors. We used data from 32 hospitals in the current MedisGroups database with at least 100 acute myocardial infarction (AMI) (<i>International Classification of Diseases, Ninth Revision, Clinical Modification [ICD-9-CM]</i>codes 410.0 to 410.9) Medicare admissions greater than age 65 years (4653 cases). We studied location of AMI, congestive heart failure (CHF) status, and patient age using the categories in Blumberg's article and calculating X<sup>2</sup>values. We then measured the effect of bias on interhospital comparisons by
Does aggressive surgery only benefit patients with less advanced ovarian cancer? Results from an international comparison within the SCOTROC-1 trial
Authors: S. C. Crawford, P. A. Vasey, J. Paul, A. Hay, J. A. Davis, S. B. Kaye
Journal: Journal of Clinical Oncology (2005)

5003 Background: Many small, retrospective clinical studies indicate that patients with ovarian cancer who have been ‘optimally’ debulked after primary surgery survive longer, and that although in most of these the chemotherapy has been variable, they have defined the standard of care with respect to the aims of surgery. In addition, it has been suggested that patients with ovarian cancer from the United Kingdom have an inferior survival compared to some other countries, possibly due to differences in surgical practice. We explored this within the context of a large international prospective randomised trial of 1st-line chemotherapy in advanced ovarian cancer (docetaxel/carboplatin vs. paclitaxel/carboplatin; SCOTROC-1). The SCOTROC surgical study is a prospective observational study. The aim was to evaluate the impact on progression free survival (PFS) of (a) cytoreductive surgery and (b) international variations in surgical practice. Methods: 1077 patients were recruited into SCOTROC-1; 689 from the UK and 388 from centres in Europe, USA and Australasia. Detailed surgical data were available for 889 patients. They were analysed within a Cox model. Results: There are three main observations: (1) More extensive surgery was performed in patients from non-UK centres and those patients were more likely to be optimally debulked (≤2cm) [71.3% vs 58.4%; p<.001]. (2) Optimal debulking is associated with an increase in PFS mainly for patients with less extensive disease at the outset [test for interaction p=0.003]. (3) Patients from the UK with no visible residual disease after surgery had a less favourable PFS compared to patients recruited from non-UK centres, who were similarly debulked [HR=1.85; 95%CI 1.16–2.97: p=0.010]. This observation appears to be related to surgical practice, and primarily lymphadenectomy. Conclusions: Increased PFS associated with ‘optimal’ surgery is mainly seen in those patients with less advanced disease. This argues for case selection rather than aggressive debulking in all cases irrespective of the extent of disease. Additionally lymphadenectomy may have beneficial effects on PFS in optimally debulked patients. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Chief Scientist Office, Edinburgh UK
Chronic Beryllium Disease: Uncommon Disease, Less Common Diagnosis
Authors: Dannie C. Middleton
Journal: Environmental Health Perspectives (1998)

Chronic beryllium disease (CBD) is typically considered only when occupational exposure to beryllium is a certainty; however, CBD has also occurred in occupational and environmental settings where exposure was unexpected. When the etiology of a case of granulomatous pulmonary disease is not determined, sarcoidosis is the
Caring for the Uninsured and Underinsured
Authors: Dimitrios G. Spigos, Bradley G. Langer
Journal: JAMA (1991)

<h3>To the Editor.—</h3> We have been fortunate to work at Cook County Hospital in Chicago, Ill, for the past 5 years and therefore have observed firsthand the care provided to the indigents of our city. While almost every other hospital avoids admitting or even transfers to us patients in unstable condition, our doors are open for every patient who seeks medical care. Both inpatient and outpatient care is based on what is best for our patients, not on DRGs (diagnosis related groups) or other reimbursement schemes. Public hospitals have chronic problems with recruiting and maintaining professional staff. Part of the problem, of course, is attributable to low salaries. The public health care commitment must include realistic professional salaries, such as those listed in the guidelines published by the Association of American Medical Colleges. Part of this cost can be defrayed by medical staff affiliation with medical schools. Such associations can
Erratum
Authors: Andrew Ghio, William Bennett, Robin Herbert, Gwen Skloot, Kristina Metzger, Philip Landrigan, Jacqueline Moline, Diane Stein, Andrew Todd, Stephen Levin, Sherry Baron, Iris Udasin
Journal: Environmental Health Perspectives (2007)

the value for the 75th percentile of monobenzyl phthalate (MBzP) was incorrect; the correct value is 0.92.The authors regret the error.
Hautkrankheiten.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PROCEEDINGS OF THE NEW YORK STATE MEDICAL ASSOCIATION.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PUBLIC HEALTH.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal