tbuckley/cabot-search huggingface dataset:
Abstract 177: Testing of a Novel Pelvic Hemostasis Belt to Control Lethal Pelvic Arterial Hemorrhage
Authors: Mohamad H Tiba, Gerard T Draucker, Brendan M McCracken, Hasan B Alam, Jonathan L Eliason, Kevin R Ward
Journal: Circulation (2014)

Objectives: Hemorrhage is the leading cause of death for both battlefield and injuries civilian. Hemorrhage caused by pelvic vascular injuries is of particular concern since it is challenging to manage or control prior to surgical intervention. Recently, there has been renewed interest in developing pre-surgical endovascular interventions to control such hemorrhage. However, other short-term techniques may be needed as a conduit to such endovascular approaches. Attempts at external tamponade of these complex injuries as a bridge to definitive surgical care of such injuries is not new. We tested a prototype device called the Pelvic Hemostasis Belt (PHB) for its ability to reduce or stop blood flow in a lethal model of pelvic arterial injury. Methods: Twelve male swine, 43(5.6) kg were utilized in this study. Animals were anesthetized, instrumented then randomized into two groups, Military Anti Shock Trousers group (MAST) and Pelvic Hemostasis Belt group (PHB). Through laparotomy, a stainless-steel monofilament suture was placed through the right iliac artery, the abdomen was closed and the suture was exteriorized. Hemorrhage was produced by pulling the suture through the iliac artery. In both groups, the hemostasis devices (MAST or BHP) were applied over the pelvis and lower abdomen for 60 minutes followed by release and monitoring for 30 minutes or until the animal expired. An infusion of 500 mL of hetastarch was started immediately after initiation of hemorrhage. Results: All animals in the PHB group and only two from the MAST group survived for 60 minutes. Average survival time for the rest of the MAST group was 44(17.9) minutes. The log-rank (Mantel-Cox) survival analysis demonstrated a significant difference in survival time between PHB and MAST group (p = 0.018). Significant differences were noted between the two groups in mean arterial pressure, lactate and central venous hemoglobin oxygen saturation levels. Conclusion: The PHB was successful in improving survival for 60 minutes after a lethal vascular injury. The Pelvic Hemostasis Belt might be helpful to bridge endovascular methods of hemorrhage control.
Drug-Eluting Stents Show Promise
Authors: Mike Mitka
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Microcirculation MR imaging for the prediction of long-term outcome in cervical cancer
Authors: N. A. Mayr, W. T. C. Yuh, D. Wu, J. Z. Wang, S. M. Edwards, V. A. Magnotta, J. F. Montebello, J. C. Grecula, M. V. Knopp
Journal: Journal of Clinical Oncology (2005)

5025 Background: The ability to predict efficacy prior to or early during the course of a therapeutic modality can lead to improved outcome by avoiding ineffectual therapies. The purpose of this study was to test if in-vivo functional MR imaging can, by reflecting microcirculatory response of tumor to cytotoxic therapy, predict failure early during the course of treatment in cervical cancer. Methods: One-hundred and one patients with cervical cancer stages IB2-IV treated with radiation/chemotherapy (RT/CT) underwent Dynamic Contrast Enhanced (DCE) MRI before (1st MRI) and during RT at 2 weeks (2nd MRI) and 4 weeks of RT (3rdMRI). Mean follow up was 4.9 years (1.5–8.0 years). Pelvic tumor control and disease-free survival were correlated with imaging parameters derived from the time/signal-intensity curve of the DCE-MRI of each tumor pixel. These included the signal intensity (SI) of the plateau phase (SIp), the lowest 2.5th and 5.0th percentiles of the entire tumor pixels (SI 2.5 and SI 5.0), the slope of SI during contrast bolus arrival, and tumor volume. Results: Logistic regression analysis of the DCE-MRI data produced correct classification of pelvic tumor recurrence in 85%. The distribution pattern of the lowest SI pixels (SI 5.0) at 2 weeks after RT start was most significant for predicting long-term pelvic tumor control and was superior to the other parameters (Table). Pre-treatment volume was of borderline significance. For survival, slope and tumor volume predicted outcome (Table). Conclusions: Based on this limited data, DCE-MR imaging parameters can predict long-term treatment outcome as early as 2 weeks after starting RT/CT - providing an opportunity to modify treatment early and optimize outcome. SI 2.5 and SI 5.0 may reflect the magnitude of poor-microcirculation regions in the tumor that are hypoxic and resistant to RT/CT. The correlation of slope and survival suggests a combined effect of tumor microcirculation on local and metastatic failure. No significant financial relationships to disclose.
Prevention of bacterial endocarditis : a statement for health professionals from the committee on rheumatic fever, endocarditis, and Kawasaki disease of the council on cardiovascular disease in the young, the American heart association
Authors: Adnan S. Dajani, Alan L. Bisno, Kyung J. Chung, David T. Durack, Michael Freed, Michael A. Gerber, Adolf W. Karchmer, H. Dean Millard, Shahbudin Rahimtoola, Stanford T. Shulman, Chatrchai Watanakunakorn, Kathryn A. Taubert
Journal: Circulation (1991)
STUDIES OF URINARY PIGMENTS IN PELLAGRA AND OTHER PATHOLOGICAL STATES. III. CERTAIN TOLUENE SOLUBLE PIGMENTS OF HUMAN AND CANINE URINE
Authors: Samuel Schwartz, James F. Marvin, John A. Layne, Cecil James Watson
Journal: Annals of Internal Medicine (1943)

Article1 August 1943STUDIES OF URINARY PIGMENTS IN PELLAGRA AND OTHER PATHOLOGICAL STATES. III. CERTAIN TOLUENE SOLUBLE PIGMENTS OF HUMAN AND CANINE URINESAMUEL SCHWARTZ, M.D., JAMES F. MARVIN, M.S., JOHN A. LAYNE, M.D., CECIL JAMES WATSON, M.D., F.A.C.P.SAMUEL SCHWARTZ, M.D.Search for more papers by this author, JAMES F. MARVIN, M.S.Search for more papers by this author, JOHN A. LAYNE, M.D.Search for more papers by this author, CECIL JAMES WATSON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-19-2-206 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptToluene preservatives of urine from pellagrins and from certain other patients suffering from malnutrition of one cause or another have been observed in many instances to develop a pink or deep red color upon standing.1, 2, 3The development of this red pigment appears not to depend upon the presence of nicotinic acid deficiency, since it was observed in the preservatives of urines from patients who did not have any evidence of this deficiency.3No change was seen in the toluene preservatives of 72 urines from 54 individuals who were normal, or who had arthritis, but no evidence of other...Bibliography1. WATSON CJ: The urinary pigments in four cases of alcoholic pellagra, Proc. Soc. Exper. Biol. and Med., 1938, xxxix, 514-518. CrossrefGoogle Scholar2. WATSON CJ: Further observations on the red pigments of pellagra urines, Proc. Soc. Exper. Biol. and Med., 1939, xli, 591-595. CrossrefGoogle Scholar3. WATSONLAYNE CJJA: Studies of urinary pigments in pellagra and other pathological states. I. Clinical observations, ANN. INT. MED., 1943, xviii, 183-199. II. The excretion of porphyrin and the urorosein reaction in dogs with experimental blacktongue, ANN. INT. MED., 1943, xviii, 200-205. Google Scholar4. CHOLEWINSKIMARCHLEWSKI JL: Absorption kurzwelligen Lichtes durch Indirubin und Indigotin, Biochem. Ztschr., 1938, ccc, 56. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, Minnesota*Received for publication August 13, 1942.From the Division of Internal Medicine, University of Minnesota Hospital, Minneapolis, Minnesota. Aided by grants from the John and Mary R. Markle Foundation, and the Research Fund of the Graduate School, University of Minnesota.†Merck & Company. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIsolierung des indigoiden Pigmentes Candidin aus Urin und Hämofiltrat von Urämikern 1 August 1943Volume 19, Issue 2Page: 206-212KeywordsArthritisGraduate medical educationHospital medicineMalnutritionNiacinPreservativesResearch fundingUrine ePublished: 1 December 2008 Issue Published: 1 August 1943 PDF downloadLoading ...
Abstract 3500: Low Molecular Weight Heparin versus Unfractionated Heparin for Anticoagulation of All Cause Atrial Fibrillation: A Comparative Cost Analysis from the NADROPAF Trial
Authors: Habib Gamra, Faouzi Addad, Mohamed Derdabi, Khaldoun Ben Hamda, Zohra Dridi, Fethi Betbout, Faouzi Maatouk, Sabri Maaoui, Hatem Bouraoui, Mohamed A Majdoub, Mohamed Ben Farhat
Journal: Circulation (2006)
Abstract 15440: A Mechanical Model Using the Law of Laplace Explains the Localization of Late Gadolinium Enhancement in the Right Ventricle in Pulmonary Arterial Hypertension
Authors: Sorin Lazar, Amit Patel, Roberto Lang, Stephen Archer
Journal: Circulation (2011)

B: Cardiac MRI (CMR) is becoming the the gold standard to evaluate the right ventricular (RV) structure and function in Pulmonary Arterial hypertension (PAH). Prior studies have identified that lat...
An investigation of neuroinflammation in the brains of patients with psoriasis: a [11C]-(R)-PK11195 positron-emission tomography study.
Authors: H.J.A. Hunter, R. Hinz, Z. Su, P.S. Talbot, A. Gerhard, C.E.M. Griffiths, C.E. Kleyn
Journal: British Journal of Dermatology (2014)
Le sinus carotidien et la zone homologue cardio-aortique: Physiologie, pharmacologie, pathologie, clinique
Authors: Corneille Heymans, J.J. Bouckaert, P. Regniers
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue
...and Crossroads Association
Authors: P. Wallace, P Mayer
Journal: BMJ (1996)

three times a day a relative who is totally incapacitated by a stroke, or of being in constant contact with a person whose mind has long gone.What carers need is financial assistance to buy the help they need to retain their sanity and to provide them with a reasonable quality of life.FRADA ESKIN Consultant in public health medicine 62 The Glen, Sheffield S10 3FN 1 Travers AF.Caring for older people: carers.BMY 1996;313:482-6. (24August.
Das Problem der Tuberkulosebehandlung mit Fettstoffen.
Authors: Ferdinand Mattausch
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2499: Effects of Nebivolol versus Carvedilol in Hypertensive Patients with Chronic Heart Failure
Authors: Giuseppe Marazzi, Maurizio Volterrani, Giuseppe Caminiti, Rosalba Massaro, Luigi Iaia, Romina Ciolli, Caterina Mammi, Lucia Gatta, Giuseppe M Rosano
Journal: Circulation (2007)
Safety and logistical use of filgrastim (FG) mobilised granulocytes (FMG) in early management of severe neutropenic sepsis (SNS) in acute leukemia (AL) autograft
Authors: K Taylor, D Moore, C Kelly, S Wright, R Rodwell, J Bashford, P Marlton, I Bunce, A Rentoul, N Williams, N Price, AJ Morton, F Passuello, J Renwick, K Lape, J Thompson
Journal: Blood (1996)
Abstract 20775: Value of Multislice Computed Tomography to Evaluate Aortic Annulus Diameter and Shape in Patients Referred for Transcathter Aortic Valve Implantation: A Comparison With TTE and TTE and Potential Impact on the Choice of the Prosthesis Diameter
Authors: Morsal Samim, Mariam Samim, Pieter R Stella, Jolanda Kluin, Faiez Ramjankhan, Gertjan Sieswerda, Pierfrancesco Agostoni, Marijke van der Linden, Lex van Herwerden, Pieter A Doevendans, Eric van Belle
Journal: Circulation (2010)

The present study evaluates the aortic annulus diameter and shape in patients with aortic stenosis referred for transcatheter aortic valve implantation (TAVI) with the Edwards SAPIEN valve using mu...
Abstract 16645: Abcc9 Contributes to Mitochondrial Katp Function and Protection From Cardiomyopathy
Authors: John Fahrenbach, Douglas Stoller, Gene Kim, Nitin Aggarwal, Babatunde Yerokun, Judy Earley, Michele Hadhazy, Nian-Qing Shi, Jonathan Makielski, Elizabeth McNally
Journal: Circulation (2011)

In response to intracellular energy supply, ATP-sensitive potassium (KATP) channels alter membrane potential and mediate cell stress response. The Abcc9 gene encodes the major regulatory subunit in the heart, sulfonylurea receptor 2 (SUR2), as well as smaller mitochondria-enriched proteins that contribute to sulfonylurea-insensitive KATP channels. Pharmacological studies suggest mitochondrial KATP channels are critical regulators of cell stress, however the molecular composition of this channel has been unclear. We now studied the role of KATP channels by deleting exon 5 of Abcc9 . This strategy ablated expression of both full length SUR2 protein as well as the smaller mitochondrial 55 KDa protein. Homozygous exon 5 (Ex5) mice died within 14 days of birth with progressive cardiac contractile dysfunction. Diazoxide was found to depolarize mitochondria from wildtype cardiomyocytes but not Ex5 mitochondria, consistent with disrupted mitochondrial KATP channels. Ex5 mitochondria had a reduced cross sectional area (WT: 1.27±0.11 vs. Ex5: 0.67±0.04µm 2 , p&lt;0.05), and Ex5 cardiomyocytes also exhibited reduced oxygen consumption(WT: 1.86±0.41 vs. Ex5: 0.61±0.14nmO 2 /s, p&lt;0.05). Deletion of exons 14 to 18 in Abcc9 disrupts full length SUR2 but leaves intact the 55 KDa protein. To determine the contribution of the mitochondrial 55 KDa protein, we compared the ability of Ex14/18 and Ex5 cardiomyocytes to withstand H2O2-induced stress. H 2 O 2 application resulted in a more rapid collapse of mitochondria membrane potential in Ex5 mitochondria (5.2±0.3s) compared to wildtype (15.1±0.6s) and Ex14/18 (13.1±0.6s) mitochondria. We conclude the Abcc9 -encoded 55 KDa protein contributes to mitochondrial KATP channels, and that mitochondrial KATP channels mediate the acute stress associated with cardiac function in the neonatal window.
A phase II study of systemic chemotherapy with TS-1 combined with cisplatin followed by surgery in advanced gastric cancer (OGSG0004).
Authors: S. Okano, Y. Nakane, K. Inoue, K. Fujitani, Y. Kimura, M. Kogire, M. Imano, T. Shimokawa, Y. Kurokawa, H. Furukawa
Journal: Journal of Clinical Oncology (2010)

e14562 Background: Some patients (pts) have locally advanced gastric cancer (LAGC) at diagnosis. S-1 combined cisplatin (CDDP) chemotherapy is an effective therapy for advanced or recurrent gastric cancer pts. It is expected that neoadjuvant chemotherapy using S-1 and CDDP will improve the prognosis of pts with LAGC. This study evaluated the feasibility and efficacy of S-1 combined CDDP followed by surgery. Methods: Eligibility criteria: pathologically confirmed gastric cancer, not type 4, no prior therapy, potentially operable disease with excessive lymph node metastases and/or invasion to adjacent organs, measurable metastatic lymph nodes on CT, 20 ≤ age < 75, ECOG PS < 2, adequate organ functions, written informed consent. S-1 was administered orally twice daily on days 1-21 at a dose of 80 mg/m2/day, and CDDP was administered intravenously at a dose of 60 mg/m2 on day 8, repeated every 5 weeks. RECIST criteria were used to assess the tumor response (TR). The TR was evaluated at the fourth or fifth week of every cycle. If the TR did not achieve a level beyond the previous state, surgery was conducted 3 to 5 weeks after the end of chemotherapy. We investigated the pts during the 3 years after surgery. Primary endpoints were the feasibility and efficacy of this regimen, and secondary endpoints were the curative operation rate, recurrent sites, and overall survival. Results: Twenty-seven pts were enrolled between 8/2001-10/2007. The median number of treatment cycles was 3 (range:1-9). The most common grade 3/4 hematologic toxicity was neutropenia (7%). Grade 3/4 nonhematologic toxicities were infrequent. There was no complete response, but a partial response was obtained in 17 pts (63.0%, CI: 42.4-80.6%). In 13 of 18 patients who underwent surgery, curative operation was performed (72.2%, CI: 46.5%-90.3%). Postoperative complications occurred in 4 of 18 patients (22.2%, CI: 6.4%-47.6%). There was neither chemotherapy- nor operation-related death. The sites of recurrence were lymphatic, 6 pts; peritoneal, 1 pt; and hematogenic, 3 pts. The median survival time was 958 days. Conclusions: This regimen was well tolerated and highly active. It could be one of the optimal neoadjuvant chemotherapies for LAGC pts. No significant financial relationships to disclose.
Successful Treatment of Invasive Aspergillosis in Chronic Granulomatous Disease by Bone Marrow Transplantation, Granulocyte Colony-Stimulating Factor–Mobilized Granulocytes, and Liposomal Amphotericin-B
Authors: Hülya Ozsahin, Maya von Planta, Irene Müller, Hans C. Steinert, David Nadal, Roger Lauener, Peter Tuchschmid, Ulrich V. Willi, Mahmut Ozsahin, Nigel E.A. Crompton, Reinhard A. Seger
Journal: Blood (1998)
Abstract 4093: CXCL16 is Marker of Inflammation, Atherosclerosis and Acute Coronary Syndromes in Humans (NPAM Young Investigator Awardee)
Authors: Michael Lehrke, Reshmaal Gomes Cumaranatunge, Martina I Lefterova, Segan C Millington, Philippe O Szapary, Robert Wilensky, Daniel J Rader, Mitchell A Lazar, Muredach P Reilly
Journal: Circulation (2006)

Background: Vascular inflammation coincides with uptake of modified lipoproteins in the pathogenesis of atherosclerosis. CXCL16 is a protein which shares scavenger receptor function, promoting upta...
Dysphagia: Diagnosis and Treatment
Authors: O. Ekberg
Journal: Annals of Internal Medicine (1989)

Anatomy and physiology.- Saliva.- Feeding respiratory pattern.- Evaluation of symptoms.- Imaging techniques and some principles of interpretation.- Neuroimaging in swallowing.- The clinical and radiological approach to dysphagia.- Neurology of swallowing and dysphagia.- Oral and pharyngeal function and dysfunction.- Pharyngeal morphology.- Pharyngeal manometry.- Surgical aspects of oral and pharyngeal dysfunction and dysphagia.- The postoperative pharynx.- Evaluation and treatment after head and neck surgery and/or chemo-radiotherapy of head and neck malignancy.- Indirect treatment of oral and pharyngeal dysfunction.- Rheologic aspects of swallowing and dysphagia.- Indirect treatment of oral and pharyngeal dysfunction.- The dietician's role in diagnosis and treatment of dysphagia.- The therapeutic swallowing study.- Transcranial magnetic stimulation (TMS).- Malnutrition in dysphagia.- Pulmonary complications in dysphagia.- Dehydration in dysphagia.- The importance of enteral nutrition.- Radiologic evaluation of esophageal function.- Esophageal morphology.- Esophageal manometry and pH-monitoring.- Intervention on the esophagus.- Gastroesophageal reflux disease, globus and dysphagia.- Endoscopy of the pharynx and esophagus.- Cross-sectional imaging of the hypopharynx and esophagus.- Pediatric aspects on dysphagia.- The pediatric esophagus.- Dysphagia in systemic disease.- The geriatric pharynx and esophagus.- Voice and dysphagia.- Psychiatric aspects of dysphagia.
A comparison of overall and disease-specific survivals following adjuvant radiotherapy with neo-adjuvant radiotherapy for rectal cancer
Authors: I. Ahmed, M. Howard, Z. Rehman, F. Ofar, P. Marley, E. O’Doherty, M. J. Martin
Journal: Journal of Clinical Oncology (2009)

e15008 Background: Preoperative radiotherapy is the preferred treatment for stage II-III rectal cancer. This arose following publication of the results of the German Rectal Cancer Study Group. It demonstrated a statistically significantly reduced local recurrence rate, and reduced toxicity for preoperative treatment compared with postoperative treatment. However, it failed to demonstrate improved overall survival. This study used the Surveillance, Epidemiology, and End Results (SEER) Program to compare overall and disease specific survival in rectal cancer patients treated with preoperative versus those receiving postoperative radiotherapy. Methods: 14,553 patients were identified with stage II-III rectal cancer, treated with either preoperative (5,136 patients) or postoperative radiotherapy (9,417 patients). Kaplan-Meier survival analyses and Cox multivariate analyses were used to compare 5 and 10 year overall and disease specific survival rates. Cause of death (COD) recorded as ‘Rectum and Rectosigmoid Junction’ was used to calculate rectal-specific survival. CODs recorded as ‘Colon excluding Rectum’ and ‘Rectum and Rectosigmoid Junction’ were used for colorectal-specific survival. Results: Kaplan-Meier analysis failed to demonstrate any statistical significant differences in survival figures. Cox multivariate analysis returned hazard ratios for overall survival of 1.207 (95% CI 1.122 - 1.298) and 1.180 (95% CI 1.103 - 1.263) at 5 and 10 years respectively for preoperative radiotherapy when compared with postoperative radiotherapy. For rectal-specific survival, 5 and 10 year hazard ratios of 1.381 (95% CI 1.239 - 1.539) and 1.342 (95% CI 1.210 - 1.489) respectively were obtained. Colorectal-specific survival returned 5 and 10 year hazard ratios of 1.222 (95% CI 1.124 - 1.329) and 1.193 (95% CI 1.101–1.292) respectively. Conclusions: Preoperative radiotherapy is the preferred treatment for stages II-III rectal cancer. This is because of its decreased risk of local recurrence and more optimal toxicity profile. However, this study suggests that preoperative radiotherapy is associated with poorer survival when compared with postoperative radiotherapy in the treatment of stage II-III rectal cancer. No significant financial relationships to disclose.