Sixty-Day Outcomes Among Patients Hospitalized With COVID-19
Authors: Vineet Chopra, Scott A. Flanders, Megan O’Malley, Anurag N. Malani, Hallie C. Prescott
Journal: Annals of Internal Medicine (2020)

Letters11 November 2020Sixty-Day Outcomes Among Patients Hospitalized With COVID-19FREEVineet Chopra, MD, MSc, Scott A. Flanders, MD, Megan O’Malley, PhD, Anurag N. Malani, MD, and Hallie C. Prescott, MD, MScVineet Chopra, MD, MScUniversity of Michigan Health System and The Michigan Hospital Medicine Safety Collaborative, Ann Arbor, MichiganSearch for more papers by this author, Scott A. Flanders, MDUniversity of Michigan Health System and The Michigan Hospital Medicine Safety Collaborative, Ann Arbor, MichiganSearch for more papers by this author, Megan O’Malley, PhDUniversity of Michigan Health System and The Michigan Hospital Medicine Safety Collaborative, Ann Arbor, MichiganSearch for more papers by this author, Anurag N. Malani, MDSt. Joseph Mercy Health System and The Michigan Hospital Medicine Safety Collaborative, Ann Arbor, MichiganSearch for more papers by this author, and Hallie C. Prescott, MD, MScUniversity of Michigan Health System and The Michigan Hospital Medicine Safety Collaborative, Ann Arbor, MichiganSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M20-5661 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Although characteristics and in-hospital outcomes for persons with coronavirus disease 2019 (COVID-19) have been well described, less is known about the longer-term outcomes of hospitalized patients.Objective: To describe 60-day postdischarge clinical, financial, and mental health outcomes of patients with COVID-19.Methods: This observational cohort study looked at patients hospitalized with COVID-19 (discharged between 16 March and 1 July 2020) at 38 hospitals participating in the MI-COVID19 initiative. The aim of MI-COVID19, a Michigan statewide collaboration sponsored by Blue Cross Blue Shield of Michigan (BCBSM) and Blue Care Network, is to improve care for patients hospitalized with COVID-19. Trained quality abstractors (often registered nurses) collect data from patient medical records using structured templates. For hospitals unable to abstract all COVID-19 hospitalizations, a sample is selected for inclusion by using a pseudo-randomization procedure (minute of hospital discharge).At 60 days after discharge, abstractors review the medical record to collect data on clinical events, including readmission (to the index hospital or any hospital viewable in the medical record) and postdischarge death. In addition, for all patients alive and not residing in a health care or correctional facility, abstractors contact patients by telephone to complete a survey about primary care follow-up, ongoing cardiopulmonary symptoms, return to normal activity, financial impact, and emotional and mental health outcomes. At least 3 attempts are made to contact patients. The study was deemed “not regulated” by the University of Michigan institutional review board (HUM 00179611).Findings: Of 1648 patients with COVID-19 admitted to 38 hospitals, 398 (24.2%) died during hospitalization and 1250 (75.8%) survived. Of 1250 patients discharged alive, 975 (78.0%) went home whereas 158 (12.6%) were discharged to a skilled nursing or rehabilitation facility (Table 1). By 60 days after discharge, an additional 84 patients (6.7% of hospital survivors and 10.4% of intensive care unit [ICU]-treated hospital survivors) had died, bringing the overall mortality rate for the cohort to 29.2%, and 63.5% for the 405 patients who received treatment in an ICU. Within 60 days of discharge, 189 patients (15.1% of hospital survivors) were rehospitalized.Table 1. Demographic and Clinical Characteristics of 1250 Survivors of COVID-19 HospitalizationOf patients alive 60 days after discharge, 488 (41.8%) were successfully contacted and completed the 60-day postdischarge telephone survey. Of these, 265 reported seeing a primary care physician within 2 weeks (Table 2). Most follow-up visits (304 of 382) occurred virtually by videoconference (161 of 382) or telephone (143 of 382), whereas 77 occurred in person and 1 was of unknown format.Table 2. 60-Day Outcomes Among 1250 Survivors of COVID-19 Hospitalization, 488 of Whom Completed the Telephone SurveyCardiopulmonary symptoms (such as cough and dyspnea) were reported by 159 patients, including 92 with new or worsening symptoms and 65 with persistent loss of taste or smell. Fifty-eight patients reported new or worsening difficulty completing activities of daily living. Among 195 patients who were employed before hospitalization, 117 had returned to work whereas 78 could not because of ongoing health issues or job loss. Of the 117 patients who returned to work, 30 reported reduced hours or modified duties due to health reasons.Nearly half of all patients (238 of 488) reported being emotionally affected by their health, and 28 sought care for mental health after discharge. Moreover, 179 patients reported at least a mild financial impact from their hospitalization, with 47 reporting use of most or all of their savings and 35 rationing food, heat, housing, or medications due to cost.Discussion: In this multihospital cohort of patients hospitalized with COVID-19 in Michigan, nearly 1 in 3 patients died during hospitalization or within 60 days of discharge. For most patients who survived, ongoing morbidity, including the inability to return to normal activities, physical and emotional symptoms, and financial loss, was common (1). These data confirm that the toll of COVID-19 extends well beyond hospitalization, a finding consistent with long-term sequelae from sepsis (2) and other severe respiratory viral illnesses (3). Although most patients saw a primary care provider after discharge, 1 in 5 had no primary care follow-up visit within 60 days of discharge. Collectively, these findings suggest that better models to support COVID-19 survivors are necessary (4).Our study has limitations. Although postdischarge chart review was completed for all patients, telephone contact occurred in fewer than half. Loss to follow-up may be nonrandom; thus, the proportion of patients who had adverse outcomes may be biased. We therefore report numbers of events, which should be interpreted as the minimum known number of patients with a given outcome. Despite these limitations, our study conveys that adverse events after COVID-19 hospitalization are common. Policies and clinical and research programs targeting these aspects are needed.References1. Carfì A, Bernabei R, Landi F; Gemelli Against COVID-19 Post-Acute Care Study Group. Persistent symptoms in patients after acute COVID-19. JAMA. 2020;324:603-5. [PMID: 32644129] doi:10.1001/jama.2020.12603 CrossrefMedlineGoogle Scholar2. Prescott HC, Angus DC. Enhancing recovery from sepsis: a review. JAMA. 2018;319:62-75. [PMID: 29297082] doi:10.1001/jama.2017.17687 CrossrefMedlineGoogle Scholar3. Ahmed H, Patel K, Greenwood DC, et al. Long-term clinical outcomes in survivors of severe acute respiratory syndrome and Middle East respiratory syndrome coronavirus outbreaks after hospitalisation or ICU admission: a systematic review and meta-analysis. J Rehabil Med. 2020;52:jrm00063. [PMID: 32449782] doi:10.2340/16501977-2694 MedlineGoogle Scholar4. Prescott HC, Girard TD. Recovery from severe COVID-19: leveraging the lessons of survival from sepsis. JAMA. 2020;324:739-40. [PMID: 32777028]doi:10.1001/jama.2020.14103 CrossrefMedlineGoogle Scholar Comments 0 Comments Sign In to Submit A Comment Steve Caritas, Professor Emeritus of Maternal Fetal Medicine, Magee-Women's Hospital, University of School of MedicineUniversity of Pittsburgh School of Medicine16 November 2020 Pennsylvania licensed physician My comment is quite short. After reviewing all charts and grafts for treatment: There is absolutely no documentation of all the various OUTPATIENT treatments available prior to hospitalization that may well have precluded becoming an inpatient. I find this totally unacceptable. Dr Joseph BellIHS23 December 2020 Follow up on comment Thank you Dr Caritas for your comment-- could you share the names of various outpatient medications that may be effective? Author, Article, and Disclosure InformationAuthors: Vineet Chopra, MD, MSc; Scott A. Flanders, MD; Megan O’Malley, PhD; Anurag N. Malani, MD; Hallie C. Prescott, MD, MScAffiliations: University of Michigan Health System and The Michigan Hospital Medicine Safety Collaborative, Ann Arbor, MichiganSt. Joseph Mercy Health System and The Michigan Hospital Medicine Safety Collaborative, Ann Arbor, MichiganAcknowledgment: The authors thank all the BCBSM Collaborative Quality Initiatives that partnered together on data collection and all the hospitals that volunteered to be part of MI-COVID19.Financial Support: From BCBSM and Blue Care Network as part of the BCBSM Value Partnerships program.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M20-5661.Reproducible Research Statement: Study protocol: Information available at https://mi-hms.org/quality-initiatives/mi-covid19-initiative. Statistical code: Available on request from Dr. O’Malley (e-mail, meganom@med.umich.edu). Data set: Not available.Corresponding Author: Vineet Chopra, MD, MSc, 2800 Plymouth Road, Building 16, #432 W, Ann Arbor, MI 48109; e-mail, vineetc@umich.edu.This article was published at Annals.org on 11 November 2020. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPathogenesis of Pulmonary Long COVID-19The effect of COVID-19 on cancer immunotherapy and cancer careLong COVID-19 Syndrome and Sudden Cardiac Death: The Phantom MenaceThe potential clinical impact and cost-effectiveness of the updated COVID-19 mRNA fall 2023 vaccines in the United StatesIntrinsic factors behind long COVID: III. 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rehabilitation measures on patients, who have undergone COVID-19, in post-acute periodManagement of Diabetes Complications During and After COVID-19Post-Pulmonary Embolism Syndrome and Functional Outcomes after Acute Pulmonary EmbolismFactors Contributing to Delayed Return to Work among French Healthcare Professionals Afflicted by COVID-19 at a Hospital in the Rhône-Alpes Region, 2021Postacute coronavirus disease‐2019 syndrome: Review of the literature and role of the pharmacistPost COVID-19 complications and follow up biomarkersComprehensive Risk Assessment of Infection Induced by SARS-CoV-2Post-COVID-19 fatigue and health-related quality of life in Saudi Arabia: a population-based studyA Prospective Study of Patients with Persistent Symptoms after SARS-CoV-2 Infection Referred to Physical Medicine and RehabilitationSolanum nigrum L. in COVID-19 and post-COVID complications: a propitious candidateLong COVID-19 Pathophysiology: What Do We Know So Far?Prevalence and risk factors of psychological symptoms and quality of life in COVID‐19 survivors: A cross‐sectional study of three different populationsReported long-term effects of COVID-19 patients after hospital discharge in JordanLong COVID: what is known and what gaps need to be addressedPulmonary rehabilitation in post COVID-19 syndromeImplementing a Multidisciplinary Post-COVID Clinic in a Small Community EnvironmentLong COVID: Clinical Findings, Pathology, and Endothelial Molecular MechanismsTCM “medicine and food homology” in the management of post-COVID disordersWorkplace factors that promote and hinder work ability and return to work among individuals with long-term effects of COVID-19: A qualitative studyLong term risk of death and readmission after hospital admission with covid-19 among older adults: retrospective cohort studyReview of Hyperpolarized Pulmonary Functional 129 Xe MR for Long‐COVIDLong COVID Incidence in a Large US Ambulatory Electronic Health Record SystemCOVID-19 and Acute Cardiac Injury: Clinical Manifestations, Biomarkers, Mechanisms, Diagnosis, and TreatmentInfluence of vaccination on adverse health outcomes after SARS‐CoV‐2 infection among individuals with alcohol use disorder: a population‐based studyReadmissions for Myocardial Infarction Among Survivors of COVID-19 HospitalizationThe SARS-CoV-2 spike protein induces long-term transcriptional perturbations of mitochondrial metabolic genes, causes cardiac fibrosis, and reduces myocardial contractile in obese micePost-COVID-19 Syndrome and Related Dysautonomia: Reduced Quality of Life, Increased Anxiety and Manifestation of Depressive Symptoms: Evidence from GreeceMyocarditis and Myocardial Injury in Long COVID Syndrome: A Comprehensive Review of the LiteratureImpact of COVID-19 on employment: sociodemographic, medical, psychiatric and neuropsychological correlatesImmunoglobulin A as a Key Immunological Molecular Signature of Post-COVID-19 ConditionsComparing severe COVID-19 outcomes of first and second/third waves: a prospective single-centre cohort study of health-related quality of life and pulmonary outcomes 6 months after infection30-Day Cardiovascular Readmissions Following Discharge With COVID-19: A US Nationwide Readmission Database Analysis From the Pandemic Year 2020Impacts of SARS-CoV-2 on diabetes mellitus: A pre and post pandemic evaluationTransitional and aftercare needs of persons recovering from COVID ‐19 using the Omaha System: A Scoping ReviewPost-COVID-19 and Mental HealthPotential Impact of Long COVID-19 on Orthodontic TreatmentThe role of immune activation and antigen persistence in acute and long COVIDPost-COVID-19 Syndrome in Neurology Patients: A Single Center ExperienceRadiological lung sequelae, functional status and symptoms in older patients 3 and 6 months after hospitalization for COVID-19 pneumoniaCardiovascular Considerations in the Management of People With Suspected Long COVIDPost-COVID Interstitial Lung Disease and Other Lung SequelaeClinical characterization and factors associated with quality of life in Long COVID patients: Secondary data analysis from a randomized clinical trialPost-COVID-19 syndrome and quality of life impairment in severe COVID-19 Mexican patientsAcute inpatient rehabilitation for COVID-19 survivors: A retrospective case seriesPost-COVID Symptoms in Occupational Cohorts: Effects on Health and Work AbilityFactors associated with oxygen requirement and persistent symptoms 1 year after severe COVID-19 infectionEuropean Working Group on SARS-CoV-2: Current Understanding, Unknowns, and Recommendations on the Neurological Complications of COVID-19Serum KL-6 levels predict clinical outcomes and are associated with MUC1 polymorphism in Japanese patients with COVID-19Post-COVID impact: Misery of the indisposedThe presence of symptoms within 6 months after COVID-19: a single-center longitudinal studyRevisiting the COVID-19 Pandemic: An Insight into Long-Term Post-COVID Complications and Repurposing of DrugsLong COVID and rehabilitationImpact of heart failure on all‐cause mortality in COVID‐19: findings from the Eurasian International RegistryLong COVID symptoms in hospital employees after post-vaccination SARS-CoV-2 infection in Austria: A study on self-reported incidence and associated factorsPrevalence of Post Recovery Symptoms among Recovered Cases of COVID-19 in PakistanLong COVID and the cardiovascular system—elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: a joint Scientific Statement of the ESC Working Groups on Cellular Biology of the Heart and Myocardial and Pericardial DiseasesSARS-COV-2 Pandemic: How to Maintain a COVID-free HospitalDietary Intake in Older Patients with Dementia Prior to and After the Onset of Coronavirus Disease 2019Neurological manifestations of long COVID: clinical aspects and impact on quality of lifePost Acute Corona Virus (Covid-19) SyndromeLong COVID Clinical ManifestationsOne-Year Adverse Outcomes Among US Adults With Post–COVID-19 Condition vs Those Without COVID-19 in a Large Commercial Insurance DatabasePsychological Wellbeing and Perceived Fatigue in Competitive Athletes after SARS-CoV-2 Infection 2 Years after Pandemic Start: Practical IndicationsEpidemiology and Clinical Presentation of COVID-19 in Older AdultsThe Very Long COVID: Persistence of Symptoms after 12–18 Months from the Onset of Infection and HospitalizationExercise tolerance, fatigue, mental health, and employment status at 5 and 12 months following COVID-19 illness in a physically trained populationPhysical function and fatigue recovery at 6 months after hospitalization for COVID ‐19Post–Acute COVID-19 Respiratory Symptoms in Patients With Asthma: An Electronic Health Records–Based StudyRationale, Design, and Characteristics of the VALIANT (COVID‐19 in Older Adults: ALongitudinal Assessment) CohortPOST-COVID SYNDROME, ETIOPATOGENESIS OF ORGANS DEFECTS IN CHILDREN LIVING IN THE CONDITIONS OF LOCAL MILITARY CONFLICTClinical features of post-COVID period. Results of an International Register "Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors (ACTIV SARS-CoV-2)" (12-month follow-up)Duration of Replication-Competent Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Shedding Among Patients With Severe or Critical Coronavirus Disease 2019 (COVID-19)Readmissions, Postdischarge Mortality, and Sustained Recovery Among Patients Admitted to Hospital With Coronavirus Disease 2019 (COVID-19)Clinical Anatomical Characteristics of Patients with Rhino-Orbit-Cerebral MucormycosisPrevalence, Patterns, and Clinical Severity of Long COVID among Chinese Medicine Telemedicine Service Users: Preliminary Results from a Cross-Sectional StudyShort- and long-term noninvasive cardiopulmonary exercise assessment in previously hospitalised COVID-19 patientsPresence of symptoms 6 weeks after COVID-19 among vaccinated and unvaccinated US healthcare personnel: a prospective cohort studyRole of the MicroRNAs in the Pathogenic Mechanism of Painful 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Observational StudyLong COVID: A New Challenge for Prevention of Obesity in WomenTreatment and prevention of the post-COVID syndromePost-COVID-19 syndrome and fibromyalgiaSevere Acute Respiratory Syndrome Coronaviruses-2 (SARS-CoV-2)Epidemiology, Symptomatology, and Risk Factors for Long COVID Symptoms: Population-Based, Multicenter StudyHuman CoronavirusesThe impact of COVID-19 pandemic on the quality of life of healthcare workers and the associated factors: A systematic reviewAppropriate Care and Post-COVID-19 SyndromePost-COVID symptoms and recovery times in hospitalized mild and moderate COVID-19 patientsSevere Acute Respiratory Syndrome Coronaviruses-2 (SARS-CoV-2)Clinical phenotypes and features of the post-COVID syndrome courseNanomedicines for the Pulmonary Delivery of AntibioticsAirway Sequelae After Mechanical Ventilation for COVID-19: Protocol for a Scoping ReviewThe long-term effects of COVID-19 on pulmonary status and quality of lifeThree Cases of Post-Covid-19 Dry Cough Treated with Maekmundong-tangPULMONARY COMPLICATIONS OF COVID-19 INFECTION POST-SIX MONTHSOne-year follow-up of the CAPSID randomized trial for high-dose convalescent plasma in severe COVID-19 patientsRussian medical society expert consensus on arterial hypertension: arterial hypertension and Post-COVID syndromeRelief of chest pain after SARS-CоV-2 vaccinationA distinct symptom pattern emerges for COVID-19 long-haul: a nationwide studyProspective telehealth analysis of functional performance, frailty, quality of life, and mental health after COVID-19 hospitalizationLong-haul COVID: healthcare utilization and medical expenditures 6 months post-diagnosisGlobal prevalence of chronic fatigue syndrome among long COVID-19 patients: A systematic review and meta-analysisFunctional, imaging, and respiratory evaluation (FIRE) of patients post-hospitalization for COVID-19: protocol for a pilot observational studyPhysiotherapeutic evaluation of patients with post COVID-19 condition: current use of measuring instruments by physiotherapists working in Austria and South TyrolHealth-related quality of life and social determinants of health following COVID-19 infection in a predominantly Latino populationEconomic evaluation of COVID-19 rapid antigen screening programs in the workplaceStudying the clinical, radiological, histological, microbiological, and immunological evolution during the different COVID-19 disease stages using minimal invasive autopsyLong COVID occurrence in COVID-19 survivorsLong COVID and symptom trajectory in a representative sample of Americans in the first year of the pandemicInternational electronic health record-derived post-acute sequelae profiles of COVID-19 patientsA multi-disciplinary rehabilitation approach for people surviving severe COVID-19—a case series and literature reviewPost‐COVID-19 syndrome: assessment of short- and long-term post-recovery symptoms in recovered cases in Saudi ArabiaLong COVID-19 Myocarditis and Various Heart Failure Presentations: A Case SeriesQuality of Life and Persistence of Symptoms in Outpatients after Recovery from COVID-19Risk of Malnutrition in Hospitalized COVID-19 Patients: A Systematic Review and Meta-AnalysisThe utility of telemedicine in managing patients after COVID-19Telerehabilitation in the Transitional Care of Patients with Sequelae Associated with COVID-19: Perception of Portuguese NursesPost-acute sequelae of COVID-19 (PASC): a meta-narrative review of pathophysiology, prevalence, and managementConsensus elements for observational research on COVID-19-related long-term outcomesPatterns of sleep disorders after a new coronavirus infection COVID-19An overview of post COVID sequelaeThe effect of Pirfenidone on pulmonary function parameters in post recovery COVID-19 patients with pulmonary fibrosis compared to placebo in a Government Medical College, West BengalThe COVID HOME study research protocol: Prospective cohort study of non-hospitalised COVID-19 patientsGlobal Prevalence of Post-Coronavirus Disease 2019 (COVID-19) Condition or Long COVID: A Meta-Analysis and Systematic ReviewLong COVID-19 syndrome: a 14-months longitudinal study during the two first epidemic peaks in Southeast BrazilCOVID Symptoms, Symptom Clusters, and Predictors for Becoming a Long-Hauler Looking for Clarity in the Haze of the PandemicReadmission Risk after COVID-19 Hospitalization: A Moderation Analysis by Vital SignsThromboprophylaxis with standard-dose vs. flexible-dose heparin for hospitalized COVID-19 patients: a target trial emulationLong-term cardiac surveillance and outcomes of COVID-19 patientsPOST COVID-19 CONDITION: NEEN FOR CONSENSUS DEFINITIONEstimated Global Proportions of Individuals With Persistent Fatigue, Cognitive, and Respiratory Symptom Clusters Following Symptomatic COVID-19 in 2020 and 2021Returning to work and the impact of post COVID-19 condition: A systematic reviewEligibility for Posthospitalization Venous Thromboembolism Prophylaxis in Hospitalized Patients With COVID‐19: A Retrospective Cohort StudyComorbidities associated with 30-day readmission following index coronavirus disease 2019 (COVID-19) hospitalization: A retrospective cohort study of 331,136 patients in the United StatesNeurological manifestations in patients with new coronavirus infection COVID-19Acute COVID-19 Syndrome Predicts Severe Long COVID-19: An Observational StudySequelae of COVID-19 among previously hospitalized patients up to 1 year after discharge: a systematic review and meta-analysisHerbal Medicines for Post-Acute Sequelae (Fatigue or Cognitive Dysfunction) of SARS-CoV-2 Infection: A Phase 2 Pilot Clinical Study ProtocolBrain Fog and Quality of Life at Work in Non-Hospitalized Patients after COVID-19Clinical Management of New-Onset Atrial Fibrillation in COVID-19 Patients Referred to a Tertiary Cardiac Arrhythmia Center after Hospital DischargeEndothelial Dysfunction in COVID-19: Potential Mechanisms and Possible Therapeutic OptionsPost-COVID-19 SyndromePost–Coronavirus Disease 2019 Pulmonary Fibrosis: Wait or Needs InterventionAn Overview of Clinical Features, and Medical Access Among Patients with Post-Acute COVID-19 Syndromes: Analysis of a Nationwide Survey in KoreaCurrent Status of Korean Medicine Treatment for Post-acute COVID-19 Syndrome: A Survey of Korean Medicine DoctorsPost-COVID syndrome? COVID-19 survivors suffer from cognitive difficulties, somatic complaints and anxietyEvaluate Post-Covid-19 Syndrome from A Biological PerspectiveEvaluating Primary Endpoints for COVID-19 Therapeutic Trials to Assess RecoveryVentilation and perfusion abnormalities following recovery from noncritical COVID-19Hypoechogenicity of brainstem raphe in long-COVID syndrome–less common but independently associated with depressive symptoms: a cross-sectional studyPost-COVID-19 condition 3 months after hospitalisation with SARS-CoV-2 in South Africa: a prospective cohort studyPost-acute COVID and long-COVID among adults and older adults in the State of Paraná, Brazil: protocol for an ambispective cohort studyMental health implications for aviators from COVID-19Durable functional limitation in patients with coronavirus disease-2019 admitted to intensive care and the effect of intermediate-dose vs standard-dose anticoagulation on functional outcomesPost COVID-19 burden: focus on the short-term conditionThe prevalence of inverse health consequences of COVID-19 vaccines: A post-vaccination studyThe prevalence of inverse health consequences of COVID-19 vaccines: A post-vaccination studyOral Sabizabulin for High-Risk, Hospitalized Adults with Covid-19: Interim AnalysisComparison between the persistence of post COVID-19 symptoms on critical patients requiring invasive mechanical ventilation and non-critical patientsImproving the Quality of Health Care through 25 Years of Statewide Collaboration in MichiganComparative efficacy of ivabradine and beta-blockers in the treatment of tachycardia in patients after COVID-19Lung Transplantation for Patients with COVID-19 Acute Respiratory Distress SyndromeEmergency medical admissions and COVID-19: impact on 30-day mortality and hospital length of stayPost-acute COVID-19 syndrome and its prolonged effects: An updated systematic reviewLong COVID endotheliopathy: hypothesized mechanisms and potential therapeutic approachesCardiac impairments in postacute COVID ‐19 with sustained symptoms: A review of the literature and proof of conceptInterstitial Lung Fibrosis Following COVID-19 PneumoniaPathogenic Connections in Post-COVID Conditions: What Do We Know in the Large Unknown? A Narrative ReviewClinical characteristics and social determinants of health associated with 30-day hospital readmissions of patients with COVID-19Clinical outcomes of COVID-19 infection in patients with pre-existing cardiovas