tbuckley/cabot-search huggingface dataset:
Sexual and reproductive health information and referrals for resettled refugee women: A survey of resettlement agencies in the United States
Authors: Tonya Katcher, Rebecca Thimmesch, Alison Spitz, Leena Kulkarni, Neelima Panth, Arlen Weiner, Michelle Woodford Martin
Journal: PLoS Medicine (2021)

Background Refugee resettlement offices are the first point of contact for newly arrived refugees and play a significant role in helping refugees acclimate and settle into life in the United States. Available literature suggests that refugee women are vulnerable to poor sexual and reproductive health (SRH) outcomes, including sexually transmitted infections and HIV infections as well as adverse pregnancy outcomes, but little is known about the role that refugee resettlement offices play in supporting refugee women’s SRH. This study examines the capacity and interest of resettlement offices in providing SRH information and referrals to newly arrived refugees. Methods and findings The research team conducted an online survey of staff members at refugee resettlement offices throughout the US in 2018 to determine (1) available SRH resources and workshops; (2) referrals to and assistance with making appointments for SRH and primary care appointments; (3) barriers to addressing SRH needs of clients; and (4) interest in building the capacity of office staff to address SRH issues. The survey was created for this study and had not been previously used or validated. Survey data underwent descriptive analysis. A total of 236 resettlement offices were contacted, with responses from 100 offices, for a total response rate of 42%. Fifteen percent ( N = 15) of refugee resettlement agencies (RRAs) who responded to the survey provide materials about SRH to clients, and 49% ( N = 49) incorporate sexual health into the classes they provide to newly arrived refugee clients. Moreover, 12% ( N = 12) of responding RRAs screen clients for pregnancy intention, and 20% ( N = 20) directly refer to contraceptive care and services. This study is limited by the response rate of the survey; no conclusions can be drawn about those offices that did not respond. In addition, the survey instrument was not validated against any other sources of information about the practices of refugee resettlement offices. Conclusions In this study, we observed that many resettlement offices do not routinely provide information or referrals for SRH needs. Responding offices cite lack of time and competing priorities as major barriers to providing SRH education and referrals to clients.
A framework for prospective, adaptive meta-analysis (FAME) of aggregate data from randomised trials
Authors: Jayne F. Tierney, David J. Fisher, Claire L. Vale, Sarah Burdett, Larysa H. Rydzewska, Ewelina Rogozińska, Peter J. Godolphin, Ian R. White, Mahesh K. B. Parmar
Journal: PLoS Medicine (2021)

Background The vast majority of systematic reviews are planned retrospectively, once most eligible trials have completed and reported, and are based on aggregate data that can be extracted from publications. Prior knowledge of trial results can introduce bias into both review and meta-analysis methods, and the omission of unpublished data can lead to reporting biases. We present a collaborative framework for prospective, adaptive meta-analysis (FAME) of aggregate data to provide results that are less prone to bias. Also, with FAME, we monitor how evidence from trials is accumulating, to anticipate the earliest opportunity for a potentially definitive meta-analysis. Methodology We developed and piloted FAME alongside 4 systematic reviews in prostate cancer, which allowed us to refine the key principles. These are to: (1) start the systematic review process early, while trials are ongoing or yet to report; (2) liaise with trial investigators to develop a detailed picture of all eligible trials; (3) prospectively assess the earliest possible timing for reliable meta-analysis based on the accumulating aggregate data; (4) develop and register (or publish) the systematic review protocol before trials produce results and seek appropriate aggregate data; (5) interpret meta-analysis results taking account of both available and unavailable data; and (6) assess the value of updating the systematic review and meta-analysis. These principles are illustrated via a hypothetical review and their application to 3 published systematic reviews. Conclusions FAME can reduce the potential for bias, and produce more timely, thorough and reliable systematic reviews of aggregate data.
Hare’s Archangel, Human Fallibility, and Utilitarian Justification(?) of Deception
Authors: Thomas May, William Paul Kabasenche
Journal: The American Journal of Bioethics (2021)

The target article by Christopher Meyers (2021) concerning justification of deception for clinical ethicists is both well-reasoned and plausible. Clearly grounded in utilitarian considerations, its...
Exploiting an Asp-Glu Switch in Glycogen Synthase Kinase 3 to Design Paralog Selective Inhibitors for Acute Myeloid Leukemia Treatment
Authors: Lina Benajiba, Florence Wagner, Arthur Campbell, Michel Weiwer, Sacher Joshua, Jennifer Gale, Linda Ross, Alexandre Puissant, Gabriela Alexe, Amy Conway, Morgan Back, Yana Pikman, Ilene Galinsky, Daniel J. DeAngelo, Richard M. Stone, Taner Kaya, Xi Shi, Matthew Robers, Thomas Machleidt, Olivier Hermine, Andrew L. Kung, Adam Stein, Michael Hemann, Edward Scolnick, Yan-Ling Zhang, Jen Pan, Edward Holson, Kimberly Stegmaier
Journal: Blood (2017)
RECURRENT HEMOLYTIC ANEMIA SECONDARY TO PROSTHETIC MITRAL VALVE: A RARE PRESENTATION
Authors: Tamer Salhab Altamimi, Devesh Rai, Zauraiz Anjum, Muhammad Waqas Tahir, Samarthkumar Thakkar, Bipul Baibhav
Journal: Journal of the American College of Cardiology (2021)
Diagnostic value of D‐dimers for limb deep vein thrombosis in children: A prospective study
Authors: Laura Avila, Nour Amiri, Eleanor Pullenayegum, Victoria Abigail Sealey, Riddhita De, Suzan Williams, Jennifer Vincelli, Leonardo R. Brandão
Journal: American Journal of Hematology (2021)

The present study sought to evaluate the discriminative and predictive ability of D-dimer for pediatric limb DVT. Children aged 28 days-18 years requiring imaging to rule out limb DVT, as per the treating clinical team, were enrolled in the study. The outcome was ultrasound proven DVT. The D-dimer levels were obtained around the time of imaging. Receiver operating characteristic (ROC) curves and logistic regression models were used for data analyses. In total, 296 patients were enrolled between 2017-2020; 204 patients were diagnosed with DVT (DVT[+]). Median D-dimer levels were 2.3 μg/ml FEU (25th-75th percentile 0.9-3.9) among DVT(+) and 1.9 μg/ml FEU (25th-75th percentile 0.8-4.0) among DVT(-) patients (p = 0.60). The area under the ROC curve (AUC) was 0.52 (95% confidence interval [CI] 0.45-0.59). The odds ratio for D-dimer levels was 1.00 (95% CI 0.99-1.01), holding confounders constant. In a sub-group exploratory analysis including 23 patients with no underlying conditions or co-morbidities, the AUC curve was 0.90 (95% CI 0.76-1.00). In conclusion, in this prospective cohort study of consecutive children with suspected limb DVT, D-dimer levels had poor discriminative and predictive ability for DVT. However, D-dimer levels showed better discriminative and predictive ability for DVT in an exploratory sample of patients with no underlying conditions or co-morbidities at the time of diagnosis.
REMOTE HOME MONITORING POST TRANSCATHETER AORTIC VALVE REPLACEMENT REDUCES 30 DAY HOSPITAL READMISSIONS
Authors: Sonja Paschke, Michael Querijero, Yuxin He, Hasan Jilaihawi, Cezar Staniloae, Homam Ibrahim, Joseph Tovar, Illya Pushkar, Stephanie Gaudio, Mathew Williams
Journal: Journal of the American College of Cardiology (2021)
THE USE OF SOLUBLE LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-1 LEVELS IN THE DIFFERENTIAL DIAGNOSIS OF MYOPERICARDITIS VERSUS ACUTE CORONARY SYNDROMES
Authors: Furkan Bölen, Oguz Konal, Rabia Korkmaz, Adem Atici, Ilkay Kartal, Ayse Senalp, Ensar Senalp, Ferruh İsman, Mehmet Agirbasli
Journal: Journal of the American College of Cardiology (2021)
Overlap of immunotherapy-related pneumonitis and COVID-19 pneumonia: diagnostic and vaccine considerations
Authors: Muhammad Bilal Abid
Journal: Journal for ImmunoTherapy of Cancer (2021)

The clinically indistinguishable overlap between pneumonitis caused due to immune checkpoint inhibition (ICI) and pneumonia associated with COVID-19 has posed considerable challenges for patients with cancer and oncologists alike. The cancer community continues to face the challenges that lay at the complex immunological intersection of immune-based cancer therapy and immune dysregulation that results from COVID-19. Is there compounded immune dysregulation that could lead to poor outcomes? Could ICIs, in fact, ameliorate SARS-CoV-2-driven T-cell exhaustion? A little more is known about the kinetics of the viral replication in immunocompromised patients now as compared with earlier during the pandemic. Working knowledge of the diagnostic and therapeutic nuances of SARS-CoV-2 infection in patients with active cancers, issues related to viability and replication potential of the virus, unclear role of corticosteroids among those with diminished or dysfunctional effector T-cell repertoire, and the type of immunotherapy with differential risk of pneumonitis will inform decision making related to immunotherapy choices and decision for ICI continuation in the era of COVID-19.
Reconstitution of biosynthetic pathway for mushroom-derived cyathane diterpenes in yeast and generation of new “non-natural” analogues
Authors: Ke Ma, Yuting Zhang, Cui Guo, Yanlong Yang, Junjie Han, Bo Yu, Wenbing Yin, Hongwei Liu
Journal: Acta Pharmaceutica Sinica B (2021)

Mushroom-derived cyathane-type diterpenes possess unusual chemical skeleton and diverse bioactivities. To efficiently supply bioactive cyathanes for deep studies and explore their structural diversity, de novo synthesis of cyathane diterpenes in a geranylgeranyl pyrophosphate engineered Saccharomyces cerevisiae is investigated. Aided by homologous analyses, one new unclustered FAD-dependent oxidase EriM accounting for the formation of allyl aldehyde and three new NADP(H)-dependent reductases in the biosynthesis of cyathanes are identified and elucidated. By combinatorial biosynthetic strategy, S. cerevisiae strains generating twenty-two cyathane-type diterpenes, including seven "unnatural" cyathane xylosides (12, 13, 14a, 14b, 19, 20, and 22) are established. Compounds 12-14, 19, and 20 show significant neurotrophic effects on PC12 cells in the dose of 6.3-25.0 μmol/L. These studies provide new insights into the divergent biosynthesis of mushroom-originated cyathanes and a straightforward approach to produce bioactive cyathane-type diterpenes.
SARS-CoV-2 Vaccine-Induced Immune Thrombotic Thrombocytopenia (Apr, 10.1056/NEJMe2106315, 2021)
Authors: D. B. Cines, J. B. Bussel
Journal: New England Journal of Medicine (2021)

The coronavirus disease 2019 (Covid-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) stimulated the development of highly effective vaccines that were produced with unprecedented speed with the use of diverse technologies  No major safety warnings, other than rare cases of anaphylaxis, were reported in the initial trials, which involved tens of thousands of adults, and the risk of serious adverse effects has remained remarkably low after vaccination of more than 400 million people worldwide to date (1) It is not surprising, however, that new reports of adverse events have emerged as many additional people are vaccinated and follow-up
ASSESSMENT OF BIOPROSTHETIC VALVE REMODELING WITH FRACTURE PROCEDURE IN VALVE-IN-VALVE TAVR BY COMPUTED TOMOGRAPHY ANGIOGRAPHY
Authors: Go Hashimoto, Joao Cavalcante, Miho Fukui, Bernardo B.C. Lopes, Hirotomo Sato, Christian Schmidt, Marcus Burns, Mario Gossl, Paul Sorajja, Mauruce Enriquez Sarano, John Lesser, Vinayak Bapat, Santiago Garcia
Journal: Journal of the American College of Cardiology (2021)
Senescence mechanisms and targets in the heart
Authors: Maggie S Chen, Richard T Lee, Jessica C Garbern
Journal: Cardiovascular Research (2021)

Abstract Cellular senescence is a state of irreversible cell cycle arrest associated with ageing. Senescence of different cardiac cell types can direct the pathophysiology of cardiovascular diseases (CVDs) such as atherosclerosis, myocardial infarction, and cardiac fibrosis. While age-related telomere shortening represents a major cause of replicative senescence, the senescent state can also be induced by oxidative stress, metabolic dysfunction, and epigenetic regulation, among other stressors. It is critical that we understand the molecular pathways that lead to cellular senescence and the consequences of cellular senescence in order to develop new therapeutic approaches to treat CVD. In this review, we discuss molecular mechanisms of cellular senescence, explore how cellular senescence of different cardiac cell types (including cardiomyocytes, cardiac endothelial cells, cardiac fibroblasts, vascular smooth muscle cells, and valve interstitial cells) can lead to CVD, and highlight potential therapeutic approaches that target molecular mechanisms of cellular senescence to prevent or treat CVD.
PREDICTIVE PERFORMANCE OF A POLYGENIC RISK SCORE FOR CORONARY HEART DISEASE IN A HEALTHY ELDERLY POPULATION
Authors: Johannes Neumann, Moeen Riaz, Andrew Bakshi, Galina Polekhina, Le Thao, Mark Nelson, Robyn Woods, Gad Abraham, Michael Inouye, Christopher Reid, Andrew Tonkin, John McNeil, Paul Lacaze
Journal: Journal of the American College of Cardiology (2021)
ANALYSIS OF ADMISSION ELECTROCARDIOGRAMS (EKGS) OF HOSPITALIZED COVID-19 PATIENTS THAT DEVELOPED SHOCK
Authors: Taya V. Glotzer, Sameer Jamal, Joseph Parrillo, Noha Gayed, Jana Tancredi, Ronaldo C. Go, Steven Hollenberg, David Landers, Lucy Safi, Zoltan Turi, Matthew Fata, Brent Klinkhammer, Roshan Shah, Themba Nyirenda, Elli Gourna Paleoudis, Michael Marafelias
Journal: Journal of the American College of Cardiology (2021)
Abstract 12904: NT-proBNP Predicts Risk for Developing Heart Failure and Cardiovascular Disease Events According to Glucose Status in the Multi-Ethnic Study of Atherosclerosis (MESA)
Authors: Khoa Nguyen, Alain Bertoni, Matthew Budoff, Christopher deFilippi, Wenjun Fan, Dawn Lombardo, Alan Maisel, Moyses Szklo, Nathan Wong
Journal: Circulation (2018)

Background: NT-proBNP and glucose status are both independent risk predictors for incident heart failure (HF) and cardiovascular disease (CVD) events. We sought to determine the prognostic role of ...
ELUCIDATION OF OBSTRUCTIVE SLEEP APNEA RELATED BLOOD PRESSURE RESPONSE USING CONTINUOUS BEAT TO BEAT BLOOD PRESSURE MONITORING
Authors: Cooper Kersey, Martin Baruch, Andrew Pattock, Patrick Stafford, Sula Mazimba, Heather Bonner, Richard Berry, David Calhoun, Younghoon Kwon
Journal: Journal of the American College of Cardiology (2021)
<i>FGFR2</i>Extracellular Domain In-Frame Deletions Are Therapeutically Targetable Genomic Alterations That Function as Oncogenic Drivers in Cholangiocarcinoma
Authors: James M. Cleary, Srivatsan Raghavan, Qibiao Wu, Yvonne Y. Li, Liam F. Spurr, Hersh V. Gupta, Douglas A. Rubinson, Isobel J. Fetter, Jason L. Hornick, Jonathan A. Nowak, Giulia Siravegna, Lipika Goyal, Lei Shi, Lauren K. Brais, Maureen Loftus, Atul B. Shinagare, Thomas A. Abrams, Thomas E. Clancy, Jiping Wang, Anuj K. Patel, Franck Brichory, Anne Vaslin Chessex, Ryan J. Sullivan, Rachel B. Keller, Sarah Denning, Emma R. Hill, Geoffrey I. Shapiro, Anna Pokorska-Bocci, Claudio Zanna, Kimmie Ng, Deborah Schrag, Pasi A. Jänne, William C. Hahn, Andrew D. Cherniack, Ryan B. Corcoran, Matthew Meyerson, Antoine Daina, Vincent Zoete, Nabeel Bardeesy, Brian M. Wolpin
Journal: Cancer Discovery (2021)

We conducted next-generation DNA sequencing on 335 biliary tract cancers and characterized the genomic landscape by anatomic site within the biliary tree. In addition to frequent FGFR2 fusions among patients with intrahepatic cholangiocarcinoma (IHCC), we identified FGFR2 extracellular domain in-frame deletions (EID) in 5 of 178 (2.8%) patients with IHCC, including two patients with FGFR2 p.H167_N173del. Expression of this FGFR2 EID in NIH3T3 cells resulted in constitutive FGFR2 activation, oncogenic transformation, and sensitivity to FGFR inhibitors. Three patients with FGFR2 EIDs were treated with Debio 1347, an oral FGFR1/2/3 inhibitor, and all showed partial responses. One patient developed an acquired L618F FGFR2 kinase domain mutation at disease progression and experienced a further partial response for 17 months to an irreversible FGFR2 inhibitor, futibatinib. Together, these findings reveal FGFR2 EIDs as an alternative mechanism of FGFR2 activation in IHCC that predicts sensitivity to FGFR inhibitors in the clinic. SIGNIFICANCE: FGFR2 EIDs are transforming genomic alterations that occur predominantly in patients with IHCC. These FGFR2 EIDs are sensitive to FGFR inhibition in vitro, and patients with these alterations benefited from treatment with FGFR inhibitors in the clinic.This article is highlighted in the In This Issue feature, p. 2355.
CLINICAL CHARACTERISTICS AND OUTCOMES IN CARDIO-ONCOLOGY PATIENTS WITH COVID-19: ANALYSIS FROM THE COVID-19 AND CANCER CONSORTIUM (CCC19) DATABASE
Authors: Melissa YY Moey, Dimpy Shah, Benjamin French, Jeanne DeCara, Toni Chouieri, Susan Dent, Nausheen Akhter, Roohi Ismail-Khan, Alicia Morgans, Anju Nohria
Journal: Journal of the American College of Cardiology (2021)
ADVERSE PROGNOSIS FOR DIABETICS VERSUS NON-DIABETICS IN NON-ISCHEMIC CARDIOMYOPATHY
Authors: Nicholas Chan, Tom Kai Ming Wang, Harry Choi, Duygu Kocyigit, Jennifer Bullen, Zoran Popovic, Scott Flamm, Brian Griffin, Wai Hong Tang, Deborah Kwon
Journal: Journal of the American College of Cardiology (2021)
LEFT VENTRICULAR THROMBOSIS FORMATION IN THE PATIENT WITH OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY FOLLOWING SARS-COV-2 INFECTION A CASE REPORT AND LITERATURE REVIEW
Authors: Ashkan Tadayoni, Ajibola Adedayo, Muhammad Dogar, Adam S Budzikowski
Journal: Journal of the American College of Cardiology (2021)
Surveillance to Track Progress Toward Polio Eradication — Worldwide, 2019–2020
Authors: Jude N. Tuma, Amanda L. Wilkinson, Ousmane M. Diop, Jaume Jorba, Tracie Gardner, Cynthia J. Snider, Abhijeet Anand, Jamal Ahmed
Journal: MMWR Morbidity and Mortality Weekly Report (2021)

When the Global Polio Eradication Initiative (GPEI) was established in 1988, an estimated 350,000 poliomyelitis cases were reported worldwide. In 2020, 140 wild poliovirus (WPV) cases were confirmed, representing a 99.99% reduction since 1988. WPV type 1 transmission remains endemic in only two countries (Pakistan and Afghanistan), but outbreaks of circulating vaccine-derived poliovirus (cVDPV) occurred in 33 countries during 2019-2020 (1,2). Poliovirus transmission is detected primarily through syndromic surveillance for acute flaccid paralysis (AFP) among children aged <15 years, with confirmation by laboratory testing of stool specimens. Environmental surveillance supplements AFP surveillance and plays an increasingly important role in detecting poliovirus transmission. Within 2 weeks of COVID-19 being declared a global pandemic (3), GPEI recommended continuing surveillance activities with caution and paused all polio supplementary immunization activities (4). This report summarizes surveillance performance indicators for 2019 and 2020 in 42 priority countries at high risk for poliovirus transmission and updates previous reports (5). In 2020, 48% of priority countries* in the African Region, 90% in the Eastern Mediterranean Region, and 40% in other regions met AFP surveillance performance indicators nationally. The number of priority countries rose from 40 in 2019 to 42 in 2020.† Analysis of 2019-2020 AFP surveillance data from 42 countries at high risk for poliovirus transmission indicates that national and subnational nonpolio AFP rates and stool specimen adequacy declined in many priority countries, particularly in the African Region, suggesting a decline in surveillance sensitivity and quality. The findings in this report can be used to guide improvements to restore a sensitive surveillance system that can track poliovirus transmission and provide evidence of interruption of transmission.
Hydrogels and Their Role in Biosensing Applications
Authors: Anna Herrmann, Rainer Haag, Uwe Schedler
Journal: Advanced Healthcare Materials (2021)

Hydrogels play an important role in the field of biomedical research and diagnostic medicine. They are emerging as a powerful tool in the context of bioanalytical assays and biosensing. In this context, this review gives an overview of different hydrogels and the role they adopt in a range of applications. Not only are hydrogels beneficial for the immobilization and embedding of biomolecules, but they are also used as responsive material, as wearable devices, or as functional material. In particular, the scientific and technical progress during the last decade is discussed. The newest hydrogel types, their synthesis, and many applications are presented. Advantages and performance improvements are described, along with their limitations.
HEMODYNAMIC AND CLINICAL CHANGES FOLLOWING TRANSCUTANEOUS MITRAL VALVE-IN-VALVE IN A PATIENT IN CARDIOGENIC SHOCK
Authors: Mohamed M. Gad, William Parker, Hassan Mehmood Lak, Nicholas Kamp, Joshua Cohen, Vinayak Nagaraja, Penelope Rampersad, Samir Kapadia
Journal: Journal of the American College of Cardiology (2021)
DETERMINANTS OF TELEMEDICINE UTILIZATION IN AMBULATORY CARDIOVASCULAR CARE DURING THE COVID-19 PANDEMIC
Authors: Njambi Mathenge, Kemar Brown, Daniela Crousillat, Jaclyn Pagliaro, Connor Grady, Nava Katz, Jagmeet Singh, Ami Bhatt
Journal: Journal of the American College of Cardiology (2021)
Genetic Studies of Atrial Fibrillation in Diverse Cohorts and Identification of Diverse Phenotypes Associated With Single Genes
Authors: Sadiya S. Khan, Elizabeth M. McNally
Journal: JAMA Cardiology (2021)

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PREDICTIVE VALUE OF AORTIC VALVE CALCIUM SCORE IN TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Mohamed E. Abdul Qader, Kai Chen, Riya Job, Carlos Vergara, David Saez, Sweet Gerlie A. Smith, Alberto Sabates, Jesus Pino, Mark Rothenberg, Elie Donath, Marcos Nores, Robert Chait
Journal: Journal of the American College of Cardiology (2021)
SIX MONTHS PUMP TREATMENT IMPROVES ARTERIAL STIFFNESS AND ENDOTHELIAL GLYCOCALYX VS INTENSIFICATION WITH MULTIPLE DAILY INSULIN INJECTIONS IN PATIENTS WITH TYPE 1 DIABETES INDEPENDENTLY OF GLYCEMIC CONTROL
Authors: Aikaterini Kountouri, John Thymis, Emmanouil Korakas, Konstantinos Balampanis, Loukia Pliouta, Foteini Kousathana, Konstantinos Katogiannis, Gavriela Kostelli, Aikaterini Barmpagianni, Stavros Liatis, Ignatios Ikonomidis, Vaia Lambadiari
Journal: Journal of the American College of Cardiology (2021)