tbuckley/cabot-search huggingface dataset:
Intubation Practices and Adverse Peri-intubation Events in Critically Ill Patients
Authors: Takahiro Masuda, Nobuyuki Nosaka, Michio Nagashima
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Family cluster of three cases of monkeypox imported from Nigeria to the United Kingdom, May 2021
Authors: Gemma Hobson, James Adamson, Hugh Adler, Richard Firth, Susan Gould, Catherine Houlihan, Christopher Johnson, David Porter, Tommy Rampling, Libuse Ratcliffe, Katherine Russell, Ananda Giri Shankar, Tom Wingfield
Journal: Eurosurveillance (2021)

Most reported cases of human monkeypox occur in Central and West Africa, where the causing virus is endemic. We describe the identification and public health response to an imported case of West African monkeypox from Nigeria to the United Kingdom (UK) in May 2021. Secondary transmission from the index case occurred within the family to another adult and a toddler. Concurrent COVID-19-related control measures upon arrival and at the hospital, facilitated detection and limited the number of potential contacts.
Effect of antibiotic stewardship interventions in primary care on antimicrobial resistance of Escherichia coli bacteraemia in England (2013–18): a quasi-experimental, ecological, data linkage study
Authors: Shirin Aliabadi, Philip Anyanwu, Elizabeth Beech, Elita Jauneikaite, Peter Wilson, Russell Hope, Azeem Majeed, Berit Muller-Pebody, Céire Costelloe
Journal: The Lancet Infectious Diseases (2021)
LATE TOXICITY AND LYMPH-NODE ENLARGEMENT AFTER CHEMORADIOTHERAPY FOR CLINICAL STAGE I ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Authors: Hayashi N, Doki Y, Takehara T, Tsuiji M, Miyata H, Konishi K, Yamazaki M, Tsutsui S, Nishida T, Hayashi Y
Journal: Annals of Oncology (2010)
SO-23 The genomic temporal heterogeneity of circulating tumor DNA in metastatic colorectal cancer under first-line treatment
Authors: Y. Huang, H. Wu, Z. Wang, Y. Jin, Y. Yao, Y. Chen, Q. Zhao, S. Chen, M. He, H. Luo, M. Qiu, D. Wang, F. Wang, Y. Li, M. Xu, F. Wang, R. Xu
Journal: Annals of Oncology (2021)
蛋白尿症のエンドセリン-1(ET-1)の尿中排泄の役割と慢性腎疾患患者のナトリウム排泄
Authors: Takayama M, Nonoguchi H, Terada Y, Koike J, Owada A, Ujiie K, Shinohara M, Kaminaga C, Tomita K, Marumo F
Journal: Journal of the American Society of Nephrology (1994)
HM1.24抗原におけるHLA-A24分子によって現れる新しい細胞障害性T細胞エピトープ
Authors: Jalili A, Ozaki S, Kosaka M, Asano J, Hara T, Kitazoe K, Tanaka Y, Sekimoto E, Shibata H, Ohshima T, Hashimato T, Abe M, Matsumoto T
Journal: Blood (2003)
Abstract 14361: Anthracycline-Induced Cardiomyopathy Patients Treated with Ventricular Assist Devices Frequently Need Biventricular Support: Data from the INTERMACS Registry
Authors: Matthias Dupont, Guilherme H Oliveira, David C Naftel, Ya Yuan, Susan L Meyers, Darlene Schmuhl, Tiffany Buda, Maria Mountis, Nicholas Smedira, Wilson W Tang, Gonzalo Gonzalez-Stawinski, Randall C Starling
Journal: Circulation (2011)

Introduction: Patients previously treated with high dose anthracyclines may develop anthracycline-induced cardiomyopathy (AC) involving both ventricles. The use of mechanical circulatory support (M...
Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction without Gut Toxicity
Authors: Hayley M. Sabol, Adam J. Ferrari, Manish Adhikari, Tânia Amorim, Kevin McAndrews, Judith Anderson, Michele Vigolo, Rajwinder Lehal, Meloney Cregor, Sharmin Khan, Pedro L. Cuevas, Jill A. Helms, Noriyoshi Kurihara, Venkat Srinivasan, Frank H. Ebetino, Robert K. Boeckman, G. David Roodman, Teresita Bellido, Jesus Delgado-Calle
Journal: Cancer Research (2021)

Systemic inhibition of Notch with γ-secretase inhibitors (GSI) decreases multiple myeloma tumor growth, but the clinical use of GSI is limited due to its severe gastrointestinal toxicity. In this study, we generated a GSI Notch inhibitor specifically directed to the bone (BT-GSI). BT-GSI administration decreased Notch target gene expression in the bone marrow, but it did not alter Notch signaling in intestinal tissue or induce gut toxicity. In mice with established human or murine multiple myeloma, treatment with BT-GSI decreased tumor burden and prevented the progression of multiple myeloma-induced osteolytic disease by inhibiting bone resorption more effectively than unconjugated GSI at equimolar doses. These findings show that BT-GSI has dual anti-myeloma and anti-resorptive properties, supporting the therapeutic approach of bone-targeted Notch inhibition for the treatment of multiple myeloma and associated bone disease. SIGNIFICANCE: Development of a bone-targeted Notch inhibitor reduces multiple myeloma growth and mitigates cancer-induced bone destruction without inducing the gastrointestinal toxicity typically associated with inhibition of Notch.
Unusual anemias
Authors: Pradyumna D. Phatak, JoAnn S. Janas, Peter A. Kouides, Ronald L. Sham, Victor J. Marder
Journal: American Journal of Hematology (1997)

Case DescriptionThe peripheral blood and bone marrow morphology in The patient is a 52-year-old white female who was this case were diagnostic of a sideroblastic anemia.In seen in consultation for anemia.Past medical history was addition, the leukopenia and the presence of vacuoles in remarkable for multiple abdominal surgeries including the myeloid and erythroid precursors were typical of those hysterectomy, partial gastrectomy for peptic ulcer disease, described in copper deficiency states [1] but are also seen cholecystectomy, and two bowel resections to relieve obin ethanol abuse, chloramphenicol exposure, stem cell struction and perforation.Since her last bowel resection disorders, and chemotherapy effect.The potential causes one year prior, she had developed dumping syndrome, of both acquired sideroblastic anemia and the vacuolated malnutrition, and weight loss of more than 20 pounds.She changes include copper deficiency, ethanol use, and mywas placed on antibiotics as well as Donnatal, Pancrease, elodysplastic syndromes.This patient had no history of ferrous sulfate, folic acid, and monthly Vitamin B 12 injecethanol use but the malnutrition secondary to bowel resections, and on her own, she took multivitamins, zinc, and tion and the history of zinc ingestion represented a potencalcium supplements.Over the ensuing months, she retial for copper deficiency as the cause of the sideroblastic gained weight from 73 to 90 pounds at about one month anemia and neutropenia [2].prior to evaluation.On physical examination, she wasThe ubiquitous distribution of copper and low daily somewhat malnourished, pulse rate and blood pressure requirements make dietary copper deficiency extremely were normal, hair was thin, lungs clear to percussion and rare.As copper absorption occurs in the small intestine, auscultation, heart normal, abdomen soft and non-tender copper deficiency may occur after prolonged parenteral without palpable organomegaly or masses, no petechiae alimentation without copper supplementation, in adults present, and neurologic exam unremarkable.Review of with short bowel and malabsorption syndromes [3], and prior laboratory data revealed a hematocrit of 26% one in marasmic infants.Dietary zinc and especially suppleyear before and 31% one month before, but only 25% at mental zinc interact with copper in a competitive manner, the time of evaluation, with a mean red blood cell volume thereby increasing fecal copper loss [2].(MCV) of 105 fl.The white blood cell count was 2,500/ This patient was instructed to discontinue zinc supplel, down from 7,000/l one month previously, but the mentation and begin copper sulfate at 5 mg each day platelet count was 334,000/l.Serum LDH was slightly orally.Her serum copper level normalized over the course elevated at 274 MU/ml (normal 100-240); serum uric acid, creatinine, total protein, and albumin were all normal.Her serum copper level was 20 g/ml (normal 80-155) and zinc level 114 g/ml (normal 50-160).
Inhibition of temperature-sensitive TRPV3 channel by two natural isochlorogenic acid isomers for alleviation of dermatitis and chronic pruritus
Authors: Hang Qi, Yuntao Shi, Han Wu, Canyang Niu, Xiaoying Sun, KeWei Wang
Journal: Acta Pharmaceutica Sinica B (2021)

Genetic gain-of-function mutations of warm temperature-sensitive transient receptor potential vanilloid 3 (TRPV3) channel cause Olmsted syndrome characterized by severe itching and keratoderma, indicating that pharmacological inhibition of TRPV3 may hold promise for therapy of chronic pruritus and skin diseases. However, currently available TRPV3 tool inhibitors are either nonselective or less potent, thus impeding the validation of TRPV3 as therapeutic target. Using whole-cell patch-clamp and single-channel recordings, we report the identification of two natural dicaffeoylquinic acid isomers isochlorogenic acid A (IAA) and isochlorogenic acid B (IAB) that selectively inhibit TRPV3 currents with IC50 values of 2.7 ± 1.3 and 0.9 ± 0.3 μmol/L, respectively, and reduce the channel open probability to 3.7 ± 1.2% and 3.2 ± 1.1% from 26.9 ± 5.5%, respectively. In vivo evaluation confirms that both IAA and IAB significantly reverse the ear swelling of dermatitis and chronic pruritus. Furthermore, the isomer IAB is able to rescue the keratinocyte death induced by TRPV3 agonist carvacrol. Molecular docking combined with site-directed mutations reveals two residues T636 and F666 critical for the binding of the two isomers. Taken together, our identification of isochlorogenic acids A and B that act as specific TRPV3 channel inhibitors and gating modifiers not only provides an essential pharmacological tool for further investigation of the channel pharmacology and pathology, but also holds developmental potential for treatment of dermatitis and chronic pruritus.
Scalable Manufacturing of CAR T Cells for Cancer Immunotherapy
Authors: Mohamed Abou-el-Enein, Magdi Elsallab, Steven A. Feldman, Andrew D. Fesnak, Helen E. Heslop, Peter Marks, Brian G. Till, Gerhard Bauer, Barbara Savoldo
Journal: Blood Cancer Discovery (2021)

Abstract As of April 2021, there are five commercially available chimeric antigen receptor (CAR) T cell therapies for hematologic malignancies. With the current transition of CAR T cell manufacturing from academia to industry, there is a shift toward Good Manufacturing Practice (GMP)–compliant closed and automated systems to ensure reproducibility and to meet the increased demand for patients with cancer. In this review, we describe current CAR T cell clinical manufacturing models and discuss emerging technologic advances that embrace scaling and production optimization. We summarize measures being used to shorten CAR T cell manufacturing times and highlight regulatory challenges to scaling production for clinical use. Significance: As the demand for CAR T cell cancer therapy increases, several closed and automated production platforms are being deployed, and others are in development. This review provides a critical appraisal of these technologies, which can be leveraged to scale and optimize the production of next-generation CAR T cells. See related video: https://aacrjournals.org/content/webinar-car-t-cell-manufacturing
Oncostatin M Receptor–Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth
Authors: Anjali Geethadevi, Ajay Nair, Deepak Parashar, Zhiqiang Ku, Wei Xiong, Hui Deng, Yongsheng Li, Jasmine George, Donna M. McAllister, Yunguang Sun, Ishaque P. Kadamberi, Prachi Gupta, Michael B. Dwinell, William H. Bradley, Janet S. Rader, Hallgeir Rui, Robert F. Schwabe, Ningyan Zhang, Sunila Pradeep, Zhiqiang An, Pradeep Chaluvally-Raghavan
Journal: Cancer Research (2021)

Abstract Although patients with advanced ovarian cancer may respond initially to treatment, disease relapse is common, and nearly 50% of patients do not survive beyond five years, indicating an urgent need for improved therapies. To identify new therapeutic targets, we performed single-cell and nuclear RNA-seq data set analyses on 17 human ovarian cancer specimens, revealing the oncostatin M receptor (OSMR) as highly expressed in ovarian cancer cells. Conversely, oncostatin M (OSM), the ligand of OSMR, was highly expressed by tumor-associated macrophages and promoted proliferation and metastasis in cancer cells. Ovarian cancer cell lines and additional patient samples also exhibited elevated levels of OSMR when compared with other cell types in the tumor microenvironment or to normal ovarian tissue samples. OSMR was found to be important for ovarian cancer cell proliferation and migration. Binding of OSM to OSMR caused OSMR–IL6ST dimerization, which is required to produce oncogenic signaling cues for prolonged STAT3 activation. Human monoclonal antibody clones B14 and B21 directed to the extracellular domain of OSMR abrogated OSM-induced OSMR–IL6ST heterodimerization, promoted the internalization and degradation of OSMR, and effectively blocked OSMR-mediated signaling in vitro. Importantly, these antibody clones inhibited the growth of ovarian cancer cells in vitro and in vivo by suppressing oncogenic signaling through OSMR and STAT3 activation. Collectively, this study provides a proof of principle that anti-OSMR antibody can mediate disruption of OSM-induced OSMR–IL6ST dimerization and oncogenic signaling, thus documenting the preclinical therapeutic efficacy of human OSMR antagonist antibodies for immunotherapy in ovarian cancer. Significance: This study uncovers a role for OSMR in promoting ovarian cancer cell proliferation and metastasis by activating STAT3 signaling and demonstrates the preclinical efficacy of antibody-based OSMR targeting for ovarian cancer treatment.
Report from the fourth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative)
Authors: J.R. Chalmers, E. Simpson, C.J. Apfelbacher, K.S. Thomas, L. Kobyletzki, J. Schmitt, J.A. Singh, Å. Svensson, H.C. Williams, K. Abuabara, V. Aoki, M. Ardeleanu, M. Awici‐Rasmussen, S. Barbarot, T.L. Berents, J. Block, A. Bragg, T. Burton, K.K. Bjerring Clemmensen, A. Creswell‐Melville, M. Dinesen, A. Drucker, L. Eckert, C. Flohr, M. Garg, L.A.A. Gerbens, A.L.B. Graff, J. Hanifin, D. Heinl, R. Humphreys, H.A. Ishii, Y. Kataoka, Y.A. Leshem, B. Marquort, M.‐A. Massuel, S. Merhand, H. Mizutani, H. Murota, D.F. Murrell, T. Nakahara, I. Nasr, K. Nograles, Y. Ohya, I. Osterloh, J. Pander, C. Prinsen, L. Purkins, M. Ridd, T. Sach, M.‐L. A. Schuttelaar, S. Shindo, J. Smirnova, A. Sulzer, E. Synnøve Gjerde, R. Takaoka, H. Vestby Talmo, M. Tauber, F. Torchet, A. Volke, C.‐F. Wahlgren, S. Weidinger, E. Weisshaar, A. Wollenberg, K. Yamaga, C.Y. Zhao, P.I. Spuls
Journal: British Journal of Dermatology (2016)

This article is a report of the fourth meeting of the Harmonising Outcome Measures for Eczema (HOME) initiative held in Malmö, Sweden on 23–24 April 2015 (HOME IV). The aim of the meeting was to achieve consensus over the preferred outcome instruments for measuring patient‐reported symptoms and quality of life for the HOME core outcome set for atopic eczema (AE). Following presentations, which included data from systematic reviews, consensus discussions were held in a mixture of whole group and small group discussions. Small groups were allocated a priori to ensure representation of different stakeholders and countries. Decisions were voted on using electronic keypads. For the patient‐reported symptoms, the group agreed by vote that itch, sleep loss, dryness, redness/inflamed skin and irritated skin were all considered essential aspects of AE symptoms. Many instruments for capturing patient‐reported symptoms were discussed [including the Patient‐Oriented SCOring Atopic Dermatitis index, Patient‐Oriented Eczema Measure (POEM), Self‐Administered Eczema Area and Severity Index, Itch Severity Scale, Atopic Dermatitis Quickscore and the Nottingham Eczema Severity Score] and, by consensus, POEM was selected as the preferred instrument to measure patient‐reported symptoms. Further work is needed to determine the reliability and measurement error of POEM. Further work is also required to establish the importance of pain/soreness and the importance of collecting information regarding the intensity of symptoms in addition to their frequency. Much of the discussion on quality of life concerned the Dermatology Life Quality Index and Quality of Life Index for Atopic Dermatitis; however, consensus on a preferred instrument for measuring this domain could not be reached. In summary, POEM is recommended as the HOME core outcome instrument for measuring AE symptoms.
The NIVO score: can it help to improve noninvasive ventilation in daily clinical practice?
Authors: Judith Elshof, Marieke L. Duiverman, Peter J. Wijkstra
Journal: European Respiratory Journal (2021)

<b>The study of Hartley designed an easy-to-use score to predict mortality in noninvasively ventilated COPD patients. More information about NIV is gained, but the exact measures on how to improve NIV in clinical practice remains uncertain.</b>https://bit.ly/3tFfg8F
P-274 Exploratory analysis of potential clinical, molecular and analytical prognostic factors of real-world patients with gastrointestinal stromal tumors: A single center study
Authors: I. Perez Criado, M. Matas Garcia, M. Delany Tijera, C. Martinez Vila, E. Cillan Narvaez, E. Casado Gonzalez
Journal: Annals of Oncology (2021)
P-276 Sex and regorafenib toxicity in refractory colorectal cancer: A safety analysis of the RegARd-C trial
Authors: C. Vandeputte, G. Bregni, G. Paraskevas, T. Guiot, P. Kehagias, A. Deleporte, K. Geboes, T. Delaunoit, G. Demolin, M. Peeters, L. D'Hondt, J. Janssens, J. Carrasco, S. Holbrechts, J. Goeminne, P. Vergauwe, J. Van Laethem, P. Flamen, A. Hendlisz, F. Sclafani
Journal: Annals of Oncology (2021)
1年(13サイクル)酢酸セゲステロンとエチニルエストラジオール避妊膣系の有効性:2つの多施設,オープンラベル,単腕,第3相試験の結果【JST・京大機械翻訳】
Authors: Archer David F, Merkatz Ruth B, Bahamondes Luis, Westhoff Carolyn L, Darney Philip, Apter Dan, Jensen Jeffrey T, Brache Vivian, Nelson Anita L, Banks Erika, Bartfai Gyorgy, Portman David J, Plagianos Marlena, Dart Clint, Kumar Narender, Creasy George W, Sitruk-Ware Regine, Blithe Diana L
Journal: The Lancet Global Health (2019)
Performance of saliva and mid-turbinate swabs for detection of the beta variant in South Africa
Authors: Chun Yat Chu, Gert Marais, Christoffel Opperman, Deelan Doolabh, Arash Iranzadeh, Carisa Marais, Helen Cox, Carolyn Williamson, Diana Hardie, Adrian Brink
Journal: The Lancet Infectious Diseases (2021)
Trust boss gets GMC warning for failing to mention that doctor he referred had raised concerns
Authors: Clare Dyer
Journal: BMJ (2021)

An NHS boss who wrongly assured the General Medical Council that a doctor he was reporting to the regulator was not a whistleblower has received a formal warning from the GMC for making a misleading and inaccurate statement.

David Rosser, then medical director of Heart of England NHS Foundation Trust, referred consultant ophthalmic surgeon Tristan Reuser to the GMC in June 2017 after the trust had decided to dismiss him. He told the GMC that Reuser had not been involved in any whistleblowing episode or other attempts to raise concerns within the organisation.

But the previous January Reuser and another consultant had made a “protected disclosure” under …
N−3 fatty acid supplementation in asthma management: A systematic review and meta‐analysis
Authors: Yu‐Hsin Wang, Shih‐Yi Huang, Han‐Pin Kuo, Hsien‐Yu Fan, André Moreira, Maria Michelle Papamichael, Yang‐Ching Chen
Journal: Allergy (2021)

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Decompression with or without Fusion in Degenerative Lumbar Spondylolisthesis
Authors: Ivar M. Austevoll, Erland Hermansen, Morten W. Fagerland, Kjersti Storheim, Jens I. Brox, Tore Solberg, Frode Rekeland, Eric Franssen, Clemens Weber, Helena Brisby, Oliver Grundnes, Knut R.H. Algaard, Tordis Böker, Hasan Banitalebi, Kari Indrekvam, Christian Hellum
Journal: New England Journal of Medicine (2021)

In patients with lumbar spinal stenosis and degenerative spondylolisthesis, it is uncertain whether decompression surgery alone is noninferior to decompression with instrumented fusion.
The etiquette of hijab: recommendations to improve care in dermatology clinics
Authors: R. Rehman, A. Chabaan, I. Hamzavi, F. Fahs, T.F. Mohammad
Journal: British Journal of Dermatology (2021)

A strong physician-patient relationship is the foundation of providing excellent patient care, as it improves providers' job satisfaction and patients' confidence, which influences their health outcomes. 1,2 Strong relationships also prompt more accurate identification of patients' needs and perceptions, which may be used as
Rapid and coagulation-independent haemostatic sealing by a paste inspired by barnacle glue
Authors: Hyunwoo Yuk, Jingjing Wu, Tiffany L. Sarrafian, Xinyu Mao, Claudia E. Varela, Ellen T. Roche, Leigh G. Griffiths, Christoph S. Nabzdyk, Xuanhe Zhao
Journal: Nature Biomedical Engineering (2021)
Chronic administration of ethanol with high vitamin A supplementation in a liquid diet to rats does not cause liver fibrosis
Authors: W.F. Seifert, A. Bosma, H.F.J. Hendriks, W.S. Blaner, R.E.W. van Leeuwen, G.C.F. van Thiel-de Ruiter, J.H.P. Wilson, D.L. Knook, A. Brouwer
Journal: Journal of Hepatology (1991)