tbuckley/cabot-search huggingface dataset:
Abstract 304: The Impact of the National Heart Foundation’s Warning Signs Campaign on Health-Seeking Behaviour in Acute Coronary Syndrome Patients
Authors: Janet Bray, Ziad Nehme, Judith Finn, Karen Smith, Michael Lim, Christopher Bladin, Dion Stub, Peter Cameron
Journal: Circulation (2018)

Introduction: Improving acute coronary syndrome (ACS) patient’s recognition and response to symptoms is key to reducing prehospital deaths. Between 2009 and 2013, the Heart Foundation of Australia ran paid mass media campaigns to improve Australians awareness of ACS symptoms and to call emergency medical services (EMS) if symptoms were experienced. This study aimed to examine the impact of this campaign on EMS use and referrals from general practitioners (GPs) in emergency department (ED) presentations in Victoria (Australia). Methods: The Department of Health and Human Services provided data from 39 public EDs contributing data to the Victorian Emergency Minimum Dataset between 2003 and 2015. We included admissions diagnosed with ACS in the dataset, and excluded presentations from aged-care facilities and inter-hospital transfers. We used logistic regression to examine the association between the campaign period and 1) EMS use and 2) patients referred to ED by GPs. Models were adjusted for the increasing population size and known predictors available in the dataset (age, sex, preferred language of English, resident of major city and presentation in winter). Results: Over the study period, there were 127,176 eligible ACS presentations (66,555 acute myocardial infarctions): 64% were male, 58% were aged over 64 years, 70% were a resident of a major city and in 90% English was their preferred language. Overall, 62% of ACS patients arrived by EMS and 8% presented via GPs. After adjusting for confounders, a significant increase in EMS use was seen during the period of campaign activity in ACS patients: adjusted odds ratio (AOR) =1.05 (95% CI:1.02-1.09, p=0.003). While, ACS ED presentations via GPs were seen to decrease (AOR=0.89, 95%CI:0.84-0.95, p&lt;0.001). Patients presenting via their GP were less likely to arrive by EMS (42% vs. 64%, p&lt;0.001). Conclusion: The Warning Signs Campaign was associated with an increase in EMS use and a decrease in ED presentations via GPs in ACS patients. Our study supports the use of public campaigns to change health seeking-behaviour for ACS. Future interventions need to focus on improving EMS use in patients presenting to GPs.
Abstract 177: Resuscitation Team Challenges During In-Hospital Cardiac Arrest: A Prospective Multicenter Study
Authors: Kasper G Lauridsen, Anders S Schmidt, Vinay M Nadkarni, Robert A Berg, Leif Bach, Dorthe S Møller, Mette Qvortrup, Betina Ø Sørensen, Karen K Dodt, Niels H Krarup, Hans Kirkegaard, Rikke Højbjerg, Rasmus P Nielsen, Bo Løfgren
Journal: Circulation (2018)

Introduction: Measured quality of CPR is often substandard compared to guideline recommendations during adult in-hospital cardiac arrest. Aim: To investigate the self-perceived CPR quality, teamwork and communication and to identify the most frequently reported challenges experienced during in-hospital cardiac arrest. Methods: Prospective multicenter study including self-reported data from resuscitation attempts treated by cardiac arrest teams in 5 Danish hospitals (1 university hospital, 4 regional hospitals). Data from October 2016 to May 2018 was included. Following each resuscitation attempt, all cardiac arrest team members were questioned by an online questionnaire, specifically on perceived CPR quality, teamwork and communication on a Likert scale. In addition, challenges experienced during the resuscitation attempt were inquired. Results: Of 491 cardiac arrests, the cardiac arrest team was actively involved in 387 cases (79%). Of 2,271 questionnaires there were 1,639 responses (response rate: 72%). Overall, 87% agreed or partially agreed that the CPR quality was optimal, 89% agreed or partially agreed that the teamwork was optimal, and 88% agreed or partially agreed that the communication was optimal. The most frequently reported challenges experienced were: too many health care providers present in the room (26%), healthcare providers poorly placed relative to each other in the room during resuscitation (16%), lacking space for resuscitation equipment (16%), problems finding resuscitation equipment (14%), problems finding the location of cardiac arrest (5%), and other challenges (10%). Challenges with too many healthcare providers in the room were associated with the total amount of persons in the room (p&lt;0.001), amount of non-team members present (P&lt;0.001) but not the number of members on the cardiac arrest team (p=0.70). Conclusions: During in-hospital resuscitation, most cardiac arrest team members perceive that CPR quality, teamwork, and communication are optimal. However, Challenges during resuscitation are not uncommon and include overcrowding, lack of space and problems locating resuscitation equipment.
Correction: Medical Civil Service
Journal: BMJ (1983)

with an acute rise in the serum aluminium concentration.Dr Small and others describe abnormalities on the electroencephalogram and seizures in their haemophiliac patient, and they comment that he had received large quantities of factor VIII over 14 years and that he tended to inject the concentrate too rapidly.He may thus have gradually accumulated a substantial amount of aluminium in his body and an acute further exposure to a high concentration of aluminium may then have proved sufficient to provoke seizures.
Physical Measures of Growth and Nutrition.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Enuresis
Authors: D. Hubble
Journal: BMJ (1950)

Involuntary micturition is the normal infantile habit both by night and by day.Children should acquire day-time control in the second year, and during the third year the dry bed should also be achieved.If, in the absence of disease, repeated involuntary micturition occurs after the third year, then to this disorder of function the name enuresis is given.To this same symptom occurring in organic disease, whether in children or in adults, the description " incontinence of urine " is applied.By its frequency alone, enuresis must be regarded as the most important disorder of function in childhood, and
Correction: Rifampicin-associated pseudomembranous colitis
Journal: BMJ (1980)

did not influence infection or inflammation, and 39 cannulae had been used once or not at all.No medication had been given through four of the 15 infected cannulae, including the septicaemic case.Significantly more of the infected than non-infected cannulae, however, had been used for blood transfusion (four out of 15 compared with four out of 87: p <0-002; y2 test with Yates's correction).We studied a second group of 20 patients to determine the risks of using the Venflon injection port for giving intravenous medication during opera- tions.The cannulae were in situ for up to two hours and no cannula infection or local inflammation occurred.
Association of Maternal Antidepressant Prescription During Pregnancy and Danish School-aged Children’s Standardized Test Scores
Authors: Huang-Lung Tsou, Mu-Hong Chen, Chih-Sung Liang
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Percutaneous nephrolithotomy.
Authors: J E Wickham, M J Kellet
Journal: BMJ (1981)

A new method of removing calculi from the renal collecting system, in which the large and traumatic incision in the loin currently used is unnecessary, was attempted in 31 patients. Small dilators were introduced over a guide wire through a nephrostomy tube into the renal pelvis and a catheter inserted. The track was dilated in stages and two days later the nephrostomy tube was removed and a cystoscope introduced into the interior of the kidney. A stone basket was introduced down the operating channel of the cystoscope and maneuvered to secure the stone; the cystoscope, stone basket, and stone were then removed. The procedure failed in 11 of the 31 patients, in five because the needle could not be placed accurately initially and in six because the stone could not be removed despite the establishment of a nephrostomy track. In the remaining 20 patients the procedure was successful. This procedure is far less traumatic than the conventional operation. With the development of a flexible nephroscope and an ultrasonic stone disintegrator it will be possible also to remove larger stones and stones in the peripheral calices using this method.
First-in-Human Phase I/IB Dose-Finding Study of Adagrasib (MRTX849) in Patients With Advanced <i>KRAS</i><sup><i>G12C</i></sup> Solid Tumors (KRYSTAL-1)
Authors: Sai-Hong Ignatius Ou, Pasi A. Jänne, Ticiana A. Leal, Igor I. Rybkin, Joshua K. Sabari, Minal A. Barve, Lyudmila Bazhenova, Melissa L. Johnson, Karen L. Velastegui, Cornelius Cilliers, James G. Christensen, Xiaohong Yan, Richard C. Chao, Kyriakos P. Papadopoulos
Journal: Journal of Clinical Oncology (2022)

Adagrasib (MRTX849) is an oral, highly selective, small-molecule, covalent inhibitor of KRASG12C. We report results from a phase I/IB study of adagrasib in non-small-cell lung cancer, colorectal cancer, and other solid tumors harboring the KRASG12C mutation.Patients with advanced KRASG12C-mutant solid tumors were treated with adagrasib 150 mg orally once daily, 300 mg once daily, 600 mg once daily, 1,200 mg once daily, or 600 mg orally twice a day using an accelerated titration design, which transitioned to a modified toxicity probability interval design when a predefined degree of toxicity was observed or target adagrasib exposure was achieved. Safety, pharmacokinetics, and clinical activity were evaluated.Twenty-five patients were enrolled and received at least one dose of adagrasib. The recommended phase II dose (RP2D) was 600 mg twice a day on the basis of safety, tolerability, and observed pharmacokinetics properties. No maximum tolerated dose was formally defined. After a median follow-up of 19.6 months, eight of 15 patients (53.3%; 95% CI, 26.6 to 78.7) with RECIST-evaluable KRASG12C-mutant non-small-cell lung cancer treated at 600 mg twice a day achieved a confirmed partial response. The median duration of response was 16.4 months (95% CI, 3.1 to not estimable). The median progression-free survival was 11.1 months (95% CI, 2.6 to not estimable). One of two patients with KRASG12C-mutant colorectal cancer treated at 600 mg twice a day achieved a partial response (duration of response, 4.2 months). At the RP2D, the most common treatment-related adverse events (any grade) were nausea (80.0%), diarrhea (70.0%), vomiting (50.0%), and fatigue (45.0%). The most common grade 3-4 treatment-related adverse event was fatigue (15.0%).Adagrasib 600 mg twice a day was well tolerated and exhibited antitumor activity in patients with advanced solid tumors harboring the KRASG12C mutation.
A phase II trial evaluating the efficacy of cabozantinib in the treatment of patients with refractory germ-cell tumors (GCT).
Authors: Jennifer King, S Dropcho, Sherry Beeler, Jessica Sastre, Nasser H. Hanna, Lawrence H. Einhorn, Nabil Adra
Journal: Journal of Clinical Oncology (2022)

TPS428 Background: While the majority of patients with metastatic testicular cancer are cured with first-line cisplatin-based chemotherapy, 20-30% of patients will relapse following initial treatment. Many will still be cured with second and even third-line chemotherapy options, but there remains a need for new therapeutic approaches for patients with relapsed/refractory disease. Cabozantinib is an oral tyrosine-kinase inhibitor (TKI) with multiple targets including c-MET, VEGF, RET, and AXL. Testicular GCT have low rates of somatic mutations, though have been shown to be associated with a gain of chromosome 7, a portion of which encodes c-MET. When hepatocyte growth factor (HGF) binds to its c-MET receptor, cell proliferation, migration, invasion, and apoptosis escape occurs. In addition, compared to normal testicular tissue, testicular GCT have been shown to have higher rates of VEGF expression. Based on these findings, we proposed a phase 2 trial with cabozantinib in patients with relapsed/refractory GCT. Methods: This phase II, single arm, open label trial with a Simon two-stage design is evaluating cabozantinib 60mg daily in patients with relapsed/refractory GCT. Eligible patients are adult men and women with GCT (seminoma, non-seminoma, or ovarian GCT) that have progressed after first-line cisplatin-based combination chemotherapy in addition to at least 1 salvage regimen and are considered incurable with standard therapies. Patients with primary mediastinal non-seminoma, late relapse, and treated stable brain metastases are eligible. 12 patients will be enrolled initially in the first stage of the Simon two-stage design. If at least one complete response (CR), partial response (PR), or stable disease (SD) for ≥3 months is achieved, the trial will be deemed worthy of further investigation and 9 additional patients will be enrolled. Patients will be treated daily with cabozantinib until time of progression or unacceptable toxicity. Primary outcome is clinical benefit rate (proportion of CR, PR, and SD for ≥3 months using RECIST 1.1, modified to include tumor markers, AFP and hCG). Secondary outcomes include objective response rate, progression-free survival, overall survival, and tolerability and toxicity of cabozantinib. Exploratory evaluation of MET overexpression by IHC and amplification by next generation sequencing in correlation with response will be performed. This study is currently enrolling patients. As of September 20, 2021, the prespecified goal for the Simon stage 1 has been met, and 7 of planned 21 patients have enrolled. Clinical trial information: NCT04876456.
Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia
Authors: Melissa M. Berrien-Elliott, Jennifer A. Foltz, David A. Russler-Germain, Carly C. Neal, Jennifer Tran, Margery Gang, Pamela Wong, Bryan Fisk, Celia C. Cubitt, Nancy D. Marin, Alice Y. Zhou, Miriam T. Jacobs, Mark Foster, Timothy Schappe, Ethan McClain, Samantha Kersting-Schadek, Sweta Desai, Patrick Pence, Michelle Becker-Hapak, Jeremy Eisele, Matthew Mosior, Lynne Marsala, Obi L. Griffith, Malachi Griffith, Saad M. Khan, David H. Spencer, John F. DiPersio, Rizwan Romee, Geoffrey L. Uy, Camille N. Abboud, Armin Ghobadi, Peter Westervelt, Keith Stockerl-Goldstein, Mark A. Schroeder, Fei Wan, Wen-Rong Lie, Patrick Soon-Shiong, Allegra A. Petti, Amanda F. Cashen, Todd A. Fehniger
Journal: Science Translational Medicine (2022)

Natural killer (NK) cells are innate lymphoid cells that eliminate cancer cells, produce cytokines, and are being investigated as a nascent cellular immunotherapy. Impaired NK cell function, expansion, and persistence remain key challenges for optimal clinical translation. One promising strategy to overcome these challenges is cytokine-induced memory-like (ML) differentiation, whereby NK cells acquire enhanced antitumor function after stimulation with interleukin-12 (IL-12), IL-15, and IL-18. Here, reduced-intensity conditioning (RIC) for
Radon in Homes
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 319: Return of Spontaneous Circulation is Not Affected by Gastric Distension
Authors: Hiroaki Hanafusa, Hiromichi Naito, Yoshiyuki Ueda, Tetsuya Yumoto, Takashi Yorifuji, Alexandra Weissman, Jon C Rittenberger, Francis X Guyette, Mamoru Fujishima, Makoto Kobayashi, Naoki Morimoto, Atsunori Nakao
Journal: Circulation (2018)

Introduction: Gastric distension is a common complication after CPR and is caused by excess gastric inflation. Consequently, regurgitation of gastric contents and diaphragmatic eventration with increased intrathoracic pressure can occur, which may lead to anoxia and ventricular diastolic dysfunction. We measured gastric volume of out-of-hospital cardiac arrest (OHCA) patients using computed tomography (CT) scan images, and examined the effect of gastric distension on the return of spontaneous circulation (ROSC). Hypothesis: Gastric distension from over-inflation is associated with decreased incidence of ROSC. Methods: We conducted a retrospective observational study with OHCA patients transported to Tsuyama Chuo Hospital from 2014 - 2017. We included cases with total body CT scan examined after ROSC or death. We excluded inter-facility transport and insertion of gastric tube before CT. We measured the total gastric volume using 3D imaging software (FUJIN Anatomia, AZE, Tokyo). Primary outcome: Comparison of gastric volume between patients with and without ROSC. Secondary outcome: Factors associated with increased gastric volume. Mann Whitney U-test was used for the primary outcome. Multivariable regression analysis was used for the secondary outcome. Results: 446 cases were included in the study. Median age was 79 [IQR: 68 - 86], 55% was male, 4% with initial rhythm VF/VT, 45% was estimated cardiac origin, 37% was witnessed arrest, 27% had ROSC. The total gastric volume was 400ml [192 - 793]. There was no difference in gastric volume between ROSC group and no-ROSC group (418 [232 - 733] vs 389 [183 - 824], p = 0.46). Airway management maneuver on arrival did not affect gastric volume (bag-valve-mask β: -99; 95% CI: -250 - 52, laryngeal tube β: -85; 95% CI: -228 - 59, endotracheal intubation: reference). Longer transport time was associated with increased the gastric volume (β: 5.6; 95% CI: 1.0 - 10) as was a non-cardiac origin of arrest (β: 121; 95% CI: 34 - 208). Conclusion: Abdominal distention was not associated with ROSC. Type of initial airway management did not significantly affect gastric volume. Factors associated with increased gastric volume at emergency department arrival were longer transportation time and non-cardiac origin of arrest.