tbuckley/cabot-search huggingface dataset:
Prevention of symptomatic recurrences of paroxysmal atrial fibrillation in patients initially tolerating antiarrhythmic therapy. A multicenter, double-blind, crossover study of flecainide and placebo with transtelephonic monitoring. Flecainide Supraventricular Tachycardia Study Group.
Authors: J LAnderson, E MGilbert, B LAlpert, R WHenthorn, A LWaldo, A KBhandari, R WHawkinson, E LPritchett
Journal: Circulation (1989)

Paroxysmal atrial fibrillation (PAF) is a problematic clinical arrhythmia that is usually symptomatic. Unfortunately, few adequate trials and trial methods are available for assessment of the value of therapy, and traditional treatment has often been ineffective or associated with unacceptable side effects. Transtelephonic monitoring is a new method that allows evaluation of paroxysmal arrhythmias and arrhythmia-related symptoms in outpatients. We used a patient-initiated transtelephonic monitor system to evaluate the potential of flecainide, a class 1C antiarrhythmic, in prevention of symptomatic recurrences of PAF. Sixty-four patients qualified for the study (two or more PAF attacks documented within a 4-week baseline period) and entered a dose-finding phase to determine drug tolerance. Dose was incremented at weekly intervals from 200-300 and finally to 400 mg/day. The largest dose that was well tolerated was selected for the 4-month, double-blind, randomized, crossover comparison with placebo. Fifty-f...
The murmur of pulmonic regurgitation in tetralogy of Fallot with absent pulmonic valve.
Authors: M EFontana, C FWooley
Journal: Circulation (1978)

Absent pulmonic valve (APV) in tetralogy of Fallot produces a pulmonic regurgitation murmur (PRM) which is usually late in onset after A2, low pitched, and of crescendo-decrescendo character. We have seen three adult patients with tetralogy of Fallot with APV and have done intracardiac sound and pressure studies in two. The PRM was loudest in the RV outflow tract (RVOT), where the onset was earlier than the murmur recorded on the chest wall. The crescendo portion of the PRM occurred during an abnormally slow decline in the RVOT pressure pulse after the crossover of PA and RVOT pressures. The RVOT pressure reached its minimum 30 msec after the RV body pressure, resulting in a pressure gradient between the two. The PRM peaked 30 msec later in the RV body than in the RVOT. The delayed precordial onset of the PRM after A2 is likely due to failure of transmission of early vibrations through the chest wall. The morphology of the PRM in tetralogy of Fallot with APV may be related to delayed relaxation with alter...
Outcomes of Pregnancy after Bariatric Surgery
Authors: Roland Devlieger, Goele Jans, Christophe Matthys
Journal: New England Journal of Medicine (2015)

n engl j med 372;23 nejm.org june 4, 2015 2266 pregnant women. The high risk of hepatitis E infection for travelers and health care and humanitarian relief workers who are deployed or traveling to areas where there is an ongoing outbreak was also recognized. (It has been reported that hepatitis E infection was diagnosed in health care workers from developed countries who had responded to outbreaks in refugee camps in Africa.3) In the absence of international guidelines, the reliance on local regulatory agencies in outbreak countries that usually have no capacity or experience to conduct qualified evaluations creates obstacles. In the meantime, the current manufacturer of the vaccine lacks the resources to complete registration outside China. One of the possible solutions is to develop a ready-to-go preemptive protocol for future outbreaks.4 Jun Zhang, M.Sc. J. Wai-Kuo Shih, Ph.D. Ning-Shao Xia
Mechanism of the serotonin effect on lung transvascular fluid and protein movement in awake sheep.
Authors: K LBrigham, P JOwen
Journal: Circulation Research (1975)

To see how serotonin affects filtration from lung vessels, we measured vascular pressures, lung lymph flow, lung lymph and blood plasma protein concentrations, arterial blood gases, cardiac output, and lung water content in unanesthetized sheep before and during intravenous serotonin infusions and compared serotonin effects with the effects of inflating a balloon in the left atrium in the same sheep. Serotonin caused a dose-related increase in lung lymph flow and a dose-related decrease in lymph-plasma protein concentration ratios. Steady-state 4-hour serotonin infusions at 4 mu-g/kg min-1 caused lymph flow to increase from 5.4 plus or minus 0.7 (SE) ml/hour to 8.3 plus or minus 1.3 ml/hour, lymph-plasma albumin ratios to fall from 0.78 plus or minus 0.05 to 0.72 plus or minus 0.04, lymph-plasma globulin ratios to fall from 0.64 plus or minus to 0.56 plus or minus 0.02, and pulmonary arterial and left atrial pressures to increase by 3 cm H-20 each. Lymph clearance and permeability-surface area products fo...
EUS-Guided Gallbladder Drainage To The Rescue In A Patient That Recovered From Covid-19
Authors: E Armellini, F Rubertà, I Pezzoli, F Macchini, E Iaculli, L Vescovi, A Piazzini Albani, F Pace
Journal: Endoscopy (2021)

The COVID-19 pandemic has rapidly affected every country and overwhelmed many healthcare systems. Intensive care treatment may be needed for extended durations. Patients experience consequences of respiratory illness and post-intensive care illness (1,2).
IMP production by ATP-depleted adult rat heart cells. Effects of glycolysis and alpha 1-adrenergic stimulation.
Authors: C MHohl, D KWimsatt, G PBrierley, R AAltschuld
Journal: Circulation Research (1989)

A rapid deenergization procedure was used to probe the regulation of in situ adenylate deaminase and 5'-nucleotidase in isolated adult rat heart cells. In cells depleted of ATP, the rate of ionosine monophosphate (IMP) production was fourfold greater in cells that had been respiring prior to deenergization than in cells that had been maintaining ATP stores through anaerobic glycolysis. This effect of respiratory inhibition was fully reversed by reaeration. When phenylephrine was present during preincubation, IMP production during a subsequent 5-minute rapid deenergization was increased by 70% in respiring cells and by 88% in those that had not been respiring. These effects of phenylephrine were abolished by prazosin. Adenosine production by cells without ATP was inversely related to that of IMP, whereas it was positively correlated with the amount of AMP remaining in cells after 5 minutes. We conclude from these data that rat heart adenylate deaminase is regulated by a product(s) of anaerobic glycolysis a...
Abstract 14806: A Kinase Interacting Protein 1 (AKIP1) Promotes Physiological Cardiac Remodeling
Authors: Kirsten T Nijholt, Harmen G Booij, Rudolf A De Boer, Silke U Oberdorf-Maass, Mario G Pavez Giani, Wiek H van Gilst, Herman H Silljé, B. Daan Westenbrink
Journal: Circulation (2019)

Introduction: A Kinase Interacting Protein 1 (AKIP1) has been proposed to serve as a nodal point for physiological cardiac hypertrophy based on studies in cultured cardiomyocytes. Whether AKIP1 reg...
Angiographic studies of atrioventricular discordance.
Authors: FAttie, JSoni, JOvseyevitz, LMuñoz-Castellanos, M RTestelli, ABuendia
Journal: Circulation (1980)

The results and value of conventional and axial angiocardiography were studied in 26 cases of atrioventricular discordance (AVD). The angiographic anatomy of this malformation was analyzed to determine the precise characteristics of atrioventricular and ventriculoarterial connections. The left and right ventricles in atrial situs solitus and levocardia show angiographic features that differ from those seen in atrial situs solitus and dextrocardia. The same differences are found in atrial situs inversus. Regardless of the type of ventriculoarterial connections, the ventricles maintain the same angiographic characteristics. The ventricular septum in AVD in situs solitus and levocardia and situs inversus and dextrocardia has a peculiar orientation. The use of axial angiocardiography facilitates detection and localization of the ventricular septal defect. In cases of malposition of the heart, the conventional frontal view allows visualization of the ventricular septum in all of its length. The axial projectio...
Reentry within the atrioventricular node: surgical cure with preservation of atrioventricular conduction.
Authors: E LPritchett, R WAnderson, D GBenditt, JKasell, LHarrison, A GWallace, W CSealy, J JGallagher
Journal: Circulation (1979)

Paroxysmal supraventricular tachycardia (PSVT) is commonly caused by reentry within the atrioventricular (AV) node. This arrhythmia was abolished by operative dissection of the AV junction in a patient with disabling tachycardia that was not controlled by drugs. The operation was intended to create complete AV block, but AV conduction persisted after surgery. An electrophysiologic study 1 year after the operation revealed that the operation changed AV conduction in both the antegrade and retrograde directions, which may explain the absence of tachycardia. The patient has been free of arrhythmias for 18 months.
Action potential alternans and irregular dynamics in quinidine-intoxicated ventricular muscle cells. Implications for ventricular proarrhythmia.
Authors: H SKaragueuzian, S SKhan, KHong, YKobayashi, TDenton, W JMandel, G ADiamond
Journal: Circulation (1993)

BACKGROUNDCardiac cells display rate-dependent beat-to-beat variations in action-potential duration (APD), action potential amplitude (APA), and excitability during periodic stimulation. We hypothesized that quinidine causes a marked increase in the variability of APD, APA, and excitability of ventricular cells isolated from quinidine-toxic, arrhythmic ventricles.METHODS AND RESULTSAction potentials were recorded from right ventricular endocardial tissues (2 x 1 cm, < 2 mm thick) isolated from dogs in which ventricular tachycardia and ventricular fibrillation (VT/VF) were induced with intravenous quinidine (80-100 mg/kg) over a 5-hour period in vivo (n = 7). As the basic cycle length (BCL) of stimulation was progressively shortened, rate-dependent variations in APD and APA occurred. The initial dynamic change was alternans of APD and APA that could be either in or out of phase between two cells. The magnitude of alternans was a function of the BCL and the strength of the stimulation current. At critically...
SARS-CoV-2 mRNA vaccines induce broad CD4+ T cell responses that recognize SARS-CoV-2 variants and HCoV-NL63
Authors: Bezawit A. Woldemeskel, Caroline C. Garliss, Joel N. Blankson
Journal: Journal of Clinical Investigation (2021)

Recent studies have shown T cell cross-recognition of SARS-CoV-2 and common cold coronavirus spike proteins. However, the effect of SARS-CoV-2 vaccines on T cell responses to common cold coronaviruses (CCCs) remains unknown. In this study, we analyzed CD4+ T cell responses to spike peptides from SARS-CoV-2 and 3 CCCs (HCoV-229E, HCoV-NL63, and HCoV-OC43) before and after study participants received Pfizer-BioNTech (BNT162b2) or Moderna (mRNA-1273) mRNA-based COVID-19 vaccines. Vaccine recipients showed broad T cell responses to the SARS-CoV-2 spike protein, and we identified 23 distinct targeted peptides in 9 participants, including 1 peptide that was targeted in 6 individuals. Only 4 of these 23 targeted peptides would potentially be affected by mutations in the UK (B.1.1.7) and South African (B.1.351) variants, and CD4+ T cells from vaccine recipients recognized the 2 variant spike proteins as effectively as they recognized the spike protein from the ancestral virus. Interestingly, we observed a 3-fold increase in the CD4+ T cell responses to HCoV-NL63 spike peptides after vaccination. Our results suggest that T cell responses elicited or enhanced by SARS-CoV-2 mRNA vaccines may be able to control SARS-CoV-2 variants and lead to cross-protection against some endemic coronaviruses.
Basic polyamino acids rich in arginine, lysine, or ornithine cause both enhancement of and refractoriness to formation of endothelium-derived nitric oxide in pulmonary artery and vein.
Authors: L JIgnarro, M EGold, G MBuga, R EByrns, K SWood, GChaudhuri, GFrank
Journal: Circulation Research (1989)

The objective of this study was to elucidate the mechanism by which polyamino acids containing L-arginine, L-lysine or L-ornithine cause endothelium-dependent relaxation of bovine intrapulmonary artery and vein. Basic but not acidic or neutral polypeptides ranging in average molecular weights from 17 to 225 kDa elicited time- and concentration-dependent relaxation and cyclic GMP accumulation in precontracted rings of artery and vein by endothelium-dependent mechanisms. Vascular responses were markedly inhibited by oxyhemoglobin, methylene blue, or potassium. The basic polyamino acids stimulated the formation and/or release of an endothelium-derived relaxing factor (EDRF) identified as nitric oxide (NO) in perfused segments of both artery and vein as assessed by bioassay. The polyamino acids and A23187 released a similar endothelium-derived NO (EDNO) from artery and vein, as assessed by the similar half-life (3-5 seconds), antagonism by superoxide anion or oxyhemoglobin, enhancement by superoxide dismutase...
Successful Radical Endoscopic Resection of a Rare “Octopus Head Like” Symptomatic Giant Lipoma of the Sigmoid Colon
Authors: R Di Mitri, D Scimeca, A Bonaccorso, E Conte, M Lo Mastro, E Unti, F Mocciaro, M Amata
Journal: Endoscopy (2021)

A Nigerian 29-year-old-female was admitted for hematochezia and obstructive symptoms. CT-scan showed a sigmoid intussusception with huge hypodense mass of adipose density.Colonoscopy/EUS confirmed a semi-peduncolated ulcerated submucosal mass (third layer). The lesion was resected “en-bloc” with large diathermic snare, using high-voltage mixed Endocut to overcome the poor electrical conductivity of fat. A small solution in the cutting edge was closed positioning endoclips.Macroscopically, the piece appeared as a smooth lesion, 7x4cm, resembling the head of an octopus. Histology showed radical resection of giant lipoma with characteristic fatty cells S-100 protein positive in the submucosal layer. Clinical course was regular.
Atrial reentry around an anatomic barrier with a partially refractory excitable gap. A canine model of atrial flutter.
Authors: L HFrame, R LPage, B FHoffman
Journal: Circulation Research (1986)

We have characterized, in dogs, a model of inducible regular atrial tachycardia that resembles atrial flutter. The model involves creating a Y-shaped lesion comprised of an intercaval incision and a connected incision across the right atrium. It is suitable for serial studies of the effects of pacing or antiarrhythmic drugs in chronically instrumented animals studied in the awake state for at least several months. The postoperative cycle length of the induced tachycardia varies from 143 to 188 msec, depending on the size of the dog. The tachycardia cycle length was consistent for each dog, and the rhythm--once induced--was very stable until terminated by pacing. The mechanism of the tachycardia was reentry due to circus movement based on the ability to induce and terminate it by premature impulses or overdrive, the ability to reset the tachycardia by single premature stimuli, the pattern of entrainment during overdrive stimulation, and the ability to terminate the tachycardia by interrupting the conductio...
Dynamic determinants of letf ventricular diastolic pressure-volume relations in man.
Authors: W HGaasch, J SCole, M AQuinones, J KAlexander
Journal: Circulation (1975)

Left ventricular (LV) diastolic pressure (P), volume (V), and rate of change of volume (dV/dt) were determined at 16.7 msec intervals in 17 patients (simultaneous micromanometer and single plane volume angiography). Four patients had mitral stenosis with atrial fibrillation and 13 patients (three normal, two congestive cardiomyophathy, three LV hypertrophy, and five coronary artery disease) were in normal sinus rhythm. Maximum early diastolic filling rates (max dV/dt) in the normal and cardiomyopathy patients were similar and ranged from 269 to 370 cc/m-2/sec; in coronary artery disease and LV hypertrophy, max dV/dt ranged from 197 to 290 cc/m-2/sec and 213 to 255 cc/m-2/sec respectively; in mitral stenosis, max dV/dt ranged from 215 to 270 cc/m-2 sec. The peak filling rate during atrial systole ranged form 60 to 240 cc/m-2/sec in the 13 patients with sinus rhythm. The instantaneous diastolic P-V data were fit by an exponential equation (P = be-kV) and the P-V relation throughout diastole was represented ...
Disorders of Porphyrin Metabolism.
Journal: Annals of Internal Medicine (1988)

The History, Classification, and Incidence of the Porphyrias.- Porphyrins and Enzymes of the Heme Biosynthetic Pathway.- The Acute Porphyrias.- Pathogenesis of the Neuropathy of Acute Porphyria.- Drugs, Chemicals, and Porphyria.- The Photochemistry, Photobiology, and Phototherapeutic Use of Porphyrins.- Cutaneous Hepatic Porphyria.- Erythropoietic Protoporphyria.- Congenital Porphyria.- Porphyrins in Diseases Other than the Porphyrias.- Porphyria in Animals.- Perspective.- References.
Modification of ventricular fibrillation latency following coronary artery occlusion in the conscious pig.
Authors: J ESkinner, J TLie, M LEntman
Journal: Circulation (1975)

Abrupt occlusion of the left anterior descending coronary artery was performed on 45 unanesthetized farm pigs in order to evaluate the relative effects on the latency to ventricular fibrillation (VFL) of 1) adaptation of the animals to the laboratory, and 2) beta-receptor blockade by propranolol. Compared to control values, VFL was greatly lengthened (i.e., VF delayed or prevented) by adaptation (P smaller than 0.01), was shortened by large (2 MG/KG) doses of racemic propranolol in unadapted animals (P smaller than 0.02), and was again increased while under the influence of the drug, by adaptation (P smaller than 0.051). Neither a lower (0.02 mg/kg) dose of racemic propranolol, 2 mg/kg of dextropropranolol, nor ventricular pacing to a higher heart rate had an effect on VFL. The results suggest that reduced psychological stress was very effective in retarding or preventing the onset of VF, that low doses of propranolol were ineffective, and that higher doses were deleterious in unadapted animals.
Transcatheter electrical ablation of right bundle branch. A method of treating macroreentrant ventricular tachycardia attributed to bundle branch reentry.
Authors: PTchou, MJazayeri, SDenker, JDongas, JCaceres, MAkhtar
Journal: Circulation (1988)

The present study describes the clinical and electrophysiological characteristics of sustained bundle branch reentrant ventricular tachycardia treated with electrical ablation of the right bundle branch. Seven patients presented with syncopal episodes, and six of the seven had documented episodes of ventricular tachycardia. All patients had depressed left ventricular ejection fraction with cardiomegaly. Six of the seven had dilated cardiomyopathy in the absence of significant coronary disease. Twelve-lead electrocardiograms in all seven patients during sinus rhythm were remarkably similar; six demonstrated intraventricular conduction defect resembling left bundle branch block, and one showed left anterior fascicular block. All patients showed prolonged His-to-ventricle intervals during sinus rhythm. Sustained ventricular tachycardia (with atrioventricular dissociation) because of bundle branch reentry was induced in all patients during baseline electrophysiological study. The His-to-ventricle intervals du...
The Arthritis Handbook—A Patient's Manual on Arthritis, Rheumatism and Gout.
Journal: Annals of Internal Medicine (1972)

doyens of French Rheumatology, played an active part.In this small book Dr. Frangon presents reminiscences of his own, and of his father and grand- father, all of whom practised with conspicuous success at Aix-les-Bains, and who are now succeeded in tum by Dr. Fran9on's son Jean.Dr. Francon describes vividly some of the many personalities who have visited Aix-les-Bains and have taken 'the cure', among them Balzac, Lamartine, Maupaussant, Verlaine, Queen Victoria, and Dom Pedron, the Emperor of Brazil.Dr. Frangon paints a convincing and charming picture of these celebrities and of their annual sojourn at Aix-les- Bains.He points out that these were the private patients of the past, the predecessors of those sent by the Securite Sociale-the French National Health Service.Today 90 per cent. of those who are treated at Aix are paid for by the State.He discusses the benefit they received from their treatment and briefly notes that taking the waters is sans risques iatrogenes, suggesting that 'the cure' at Aix may well be less dangerous than swallowing some of the pills that we are accustomed to prescribe for our rheumatic patients.
Single and two-dimensional echocardiographic visualization of the effects of septal myectomy in idiopathic hypertrophic subaortic stenosis.
Authors: J NSchapira, D RStemple, R PMartin, HRakowski, E BStinson, R LPopp
Journal: Circulation (1978)

Although the postoperative hemodynamic and echocardiographic features of idiopathic hypertrophic subaortic stenosis have been studied, the expected consistent postoperative thinning of the interventricular septum has not been reported. In this study, the short-term effects of septal myectomy were evaluated in 16 patients. All patients were assessed with pre- and postoperative hemodynamic studies and M-mode echocardiograms, and six of the 16 patients had pre- and postoperative two-dimensional echocardiograms. The mean resting preoperative gradient of 74 mm Hg (range 10--190 mm Hg), which fell to a mean resting postoperative gradient of 8 mm Hg (range 0--25 mm Hg), was associated with decreased end-diastolic interventricular septal thickness at the midventricular level in 14 of 16 patients and at the subaortic level in 16 of 16 patients by M-mode echocardiography. The group also demonstrated changes in left ventricular outflow tract configuration and dimension, mitral valve systolic anterior motion, mitral ...
Isolation, characterization, and localization of cardiac collagen type VI. Associations with other extracellular matrix components.
Authors: R IBashey, AMartinez-Hernandez, S AJimenez
Journal: Circulation Research (1992)

We have isolated and characterized collagen type VI from murine, canine, and nonhuman primate hearts. In the three species studied, collagen type I was the major collagenous component of the cardiac interstitium (80% of total collagen), whereas collagen type VI represented approximately 5% of total collagen. To define the exact distribution of collagen type VI and its possible interactions with other components of the cardiac extracellular matrix, collagen types I, III, IV, and VI, laminin, and fibronectin were localized in the rat myocardium by immunohistochemistry, using monospecific antibodies. In the rat myocardium, collagen type VI was prevalent in the media and adventitia of muscular arteries, in fine connective tissue septa, in the area surrounding capillaries, and in the delicate endomysium in proximity to myocardial cells. When compared with the immunohistochemical localization of collagen types I, III, and IV, laminin, and fibronectin, the continuity and hierarchical organization of the cardiac ...
Shall The Journal be Removed to Washington?
Authors: S. E. Hampton
Journal: JAMA (1891)

<h3>To the Editor:</h3> —The<i>location</i>is of much less interest than the<i>character</i>ofThe Journal. The members of Congress are very careful about their journal. It is a record of their doings. It is a photograph, so to speak, of each individual as well as the whole. A journal goes into history as the exponent of this or that body of men. Now, Sir, I submit that all this squabble about<i>location</i>, will not appear upon the page of history as reflecting a very bright halo of glory from the A. M. A. Therefore, I move the previous question. Let us have no more of it. Milton, Ky., March 12, 1891.