tbuckley/cabot-search huggingface dataset:
CHARACTERISTICS AND OUTCOMES OF PATIENTS WITH MILDLY-ELEVATED PRESSURES (MEP) AND PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION (PAH): INSIGHTS FROM OPUS/ORPHEUS
Authors: Matthew Lammi, Richard Channick, Kelly Chin, Nick Kim, Rose Ong, Mark Rocco, Graham Wetherill, Vallerie McLaughlin
Journal: Journal of the American College of Cardiology (2021)
Ultrasmall Ga-ICG nanoparticles based gallium ion/photodynamic synergistic therapy to eradicate biofilms and against drug-resistant bacterial liver abscess
Authors: Tingting Xie, Yuchen Qi, Yangyang Li, Feilu Zhang, Wanlin Li, Danni Zhong, Zhe Tang, Min Zhou
Journal: Bioactive Materials (2021)

Pyogenic liver abscess and keratitis are aggressive bacterial infections and the treatment has failed to eradicate bacteria in infectious sites completely owing to the currently severe drug resistance to existing antibiotics. Here, we report a simple and efficient one-step development of ultrasmall non-antibiotic nanoparticles (ICG-Ga NPs) containing clinically approved gallium (III) (Ga3+) and liver targeting indocyanine green (ICG) molecules to eradicate multi-drug resistant (MDR) bacteria thought the synergetic effect of photodynamic therapy and iron metabolism blocking. The ICG-Ga NPs induced photodynamic effect could destroy the bacterial membrane, further boost the endocytosis of Ga3+, then replace iron in bacteria cells to disrupt bacterial iron metabolism, and demonstrate the synergetic bacterial killing and biofilm disrupting effects. The ICG-Ga NPs show an excellent therapeutic effect against extended spectrum β-lactamases Escherichia coli (ESBL E. coli) and significantly improve treatment outcomes in infected liver abscess and keratitis. Meanwhile, the ultrasmall size of ICG-Ga NPs could be cleared rapid via renal clearance route, guaranteeing the biocompatibility. The protective effect and good biocompatibility of ICG-Ga NPs will facilitate clinical treatment of bacteria infected diseases and enable the development of next-generation non-antibiotic antibacterial agents.
USE OF SPECTRAL DOPPLER TO LOCALIZE LEVEL OF OBSTRUCTION IN LATENT LEFT VENTRICULAR OUT FLOW TRACT OBSTRUCTION
Authors: Kirtivardhan Vashistha, Jayshiv Badlani, Abhas Khurana, Adee Elhamdani, Pietro Bajona, Jennifer Keeley, Srinivas Murali, Craig Alpert, Vinh Nguyen
Journal: Journal of the American College of Cardiology (2021)
UNDERUTILIZATION OF STATIN THERAPY IN PATIENTS WITH END-STAGE LIVER DISEASE AND CORONARY ARTERY CALCIFICATION
Authors: Gregory J. Sinner, Do Hyun Yun, Mihir G. Shah, Vedant Gupta, Malay B. Shah, Roberto Gedaly, Vincent Sorrell, Steve Leung
Journal: Journal of the American College of Cardiology (2021)
DIFFERENTIAL PROGRESSION OF CORONARY ATHEROSCLEROSIS ACCORDING TO PLAQUE COMPOSITION: CLUSTER ANALYSIS OF THE PARADIGM REGISTRY
Authors: Yeonyee Elizabeth Yoon, Lohendran Baskaran, Benjamin C. Lee, Mohit Kumar Pandey, Benjamin Goebel, Sang-Eun Lee, Daniele Andreini, Matthew Budoff, Kavitha Chinnaiyan, Jung Hyun Choi, Eun Ju Chun, Conte Edoardo, Martin Hadamitzky, Yong Jin Kim, Byoung Kwon Lee, Jonathon Leipsic, Erica Maffei, Pedro de Araújo Gonçalves, Gianluca Pontone, Sanghoon Shin, Jagat Narula, Jeroen Bax, Fay Lin, Leslee Shaw, Hyuk-Jae Chang
Journal: Journal of the American College of Cardiology (2021)
2012 ACCF/AHA/ACR/SCAI/SIR/STS/SVM/SVN/SVS Key Data Elements and Definitions for Peripheral Atherosclerotic Vascular Disease
Authors: Mark A. Creager, Michael Belkin, Edward I. Bluth, Donald E. Casey, Seemant Chaturvedi, Michael D. Dake, Jerome L. Fleg, Alan T. Hirsch, Michael R. Jaff, John A. Kern, David J. Malenka, Edward T. Martin, Emile R. Mohler, Timothy Murphy, Jeffrey W. Olin, Judith G. Regensteiner, Robert H. Rosenwasser, Peter Sheehan, Kerry J. Stewart, Diane Treat-Jacobson, Gilbert R. Upchurch, Christopher J. White, Jack A. Ziffer
Journal: Circulation (2011)
RELATIONSHIP OF C-PADDLE ORIENTATION AND HAT-MARKER POSITIONING WITH NEOCOMMISSURAL OVERLAP AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Makoto Takamatsu, Yasushi Fuku, Kazushige Kadota, Masanobu Ohya, Akihiro Ikuta, Tatsuhiko Komiya
Journal: Journal of the American College of Cardiology (2021)
Enterocutaneous fistula closure using a balloon-assisted enteroscope preloaded with an over-the-scope clip – narrowing the gap
Authors: Ramzi Mulki, Ali Ahmed, Kondal Kyanam, Shajan Peter
Journal: Endoscopy (2021)

Enterocutaneous fistulas (ECFs) are abnormal connections between the intestinal tract and the skin. The over-the-scope (OTS) clip system is an effective tool in closing gastrointestinal leaks, perforations, and fistulas [1] [2].
Atrial Fibrillation and Ischemic Stroke With the Amyloidogenic V122I Transthyretin Variant Among Black Americans
Authors: Senthil Selvaraj, Brian Claggett, Masatoshi Minamisawa, B. Gwen Windham, Lin Y. Chen, Riccardo M. Inciardi, Joel N. Buxbaum, Thomas H. Mosley, Amil M. Shah, Scott D. Solomon
Journal: Journal of the American College of Cardiology (2021)
Weight Change and the Development of Nonalcoholic Fatty Liver Disease in Metabolically Healthy Overweight Individuals
Authors: In Young Cho, Yoosoo Chang, Eunju Sung, Jae-Heon Kang, Hocheol Shin, Sarah H. Wild, Christopher D. Byrne, Seungho Ryu
Journal: Clinical Gastroenterology and Hepatology (2021)
COVID-19 OUTCOMES AND CLINICAL CORRELATION WITH MYOCARDIAL INJURY ON ADMISSION TO HOSPITAL
Authors: Gavin Manmathan, Debbie Falconer, Samuel Conway, Athanasios Kosovitsas, Zakee Abdi, Alan Hunter, Callum Little, Colette Smith, Sabine Kinloch de Loes, Margaret A. Johnson, Roby Rakhit
Journal: Journal of the American College of Cardiology (2021)
CONTINUED TREATMENT WITH SEMAGLUTIDE 2.4 MG LEADS TO SUSTAINED IMPROVEMENTS IN CARDIOMETABOLIC RISK FACTORS IN THE STEP 4 TRIAL
Authors: Subodh Verma, Meena Bhatta, Melanie Davies, John Deanfield, Tim Garvey, Camilla Jensen, Usman Khalid, Robert Kushner, Domenica M. Rubino, Mikhail Kosiborod
Journal: Journal of the American College of Cardiology (2021)
Trastuzumab deruxtecan (DS-8201) in patients with HER2-expressing metastatic colorectal cancer (DESTINY-CRC01): a multicentre, open-label, phase 2 trial
Authors: Salvatore Siena, Maria Di Bartolomeo, Kanwal Raghav, Toshiki Masuishi, Fotios Loupakis, Hisato Kawakami, Kensei Yamaguchi, Tomohiro Nishina, Marwan Fakih, Elena Elez, Javier Rodriguez, Fortunato Ciardiello, Yoshito Komatsu, Taito Esaki, Ki Chung, Zev Wainberg, Andrea Sartore-Bianchi, Kapil Saxena, Eriko Yamamoto, Emarjola Bako, Yasuyuki Okuda, Javad Shahidi, Axel Grothey, Takayuki Yoshino
Journal: The Lancet Oncology (2021)
Phylogroup stability contrasts with high within sequence type complex dynamics of Escherichia coli bloodstream infection isolates over a 12-year period
Authors: Guilhem Royer, Mélanie Mercier Darty, Olivier Clermont, Bénédicte Condamine, Cédric Laouenan, Jean-Winoc Decousser, David Vallenet, Agnès Lefort, Victoire de Lastours, Erick Denamur
Journal: Genome Medicine (2021)

Abstract Background Escherichia coli is the leading cause of bloodstream infections, associated with a significant mortality. Recent genomic analyses revealed that few clonal lineages are involved in bloodstream infections and captured the emergence of some of them. However, data on within sequence type (ST) population genetic structure evolution are rare. Methods We compared whole genome sequences of 912 E . coli isolates responsible for bloodstream infections from two multicenter clinical trials that were conducted in the Paris area, France, 12 years apart, in teaching hospitals belonging to the same institution (“Assistance Publique-Hôpitaux de Paris”). We analyzed the strains at different levels of granularity, i.e., the phylogroup, the ST complex (STc), and the within STc clone taking into consideration the evolutionary history, the resistance, and virulence gene content as well as the antigenic diversity of the strains. Results We found a mix of stability and changes overtime, depending on the level of comparison. Overall, we observed an increase in antibiotic resistance associated to a restricted number of genetic determinants and in strain plasmidic content, whereas phylogroup distribution and virulence gene content remained constant. Focusing on STcs highlighted the pauci-clonality of the populations, with only 11 STcs responsible for more than 73% of the cases, dominated by five STcs (STc73, STc131, STc95, STc69, STc10). However, some STcs underwent dramatic variations, such as the global pandemic STc131, which replaced the previously predominant STc95. Moreover, within STc131, 95 and 69 genomic diversity analysis revealed a highly dynamic pattern, with reshuffling of the population linked to clonal replacement sometimes coupled with independent acquisitions of virulence factors such as the pap gene cluster bearing a papGII allele located on various pathogenicity islands. Additionally, STc10 exhibited huge antigenic diversity evidenced by numerous O:H serotype/ fimH allele combinations, whichever the year of isolation. Conclusions Altogether, these data suggest that the bloodstream niche is occupied by a wide but specific phylogenetic diversity and that highly specialized extra-intestinal clones undergo frequent turnover at the within ST level. Additional worldwide epidemiological studies overtime are needed in different geographical and ecological contexts to assess how generalizable these data are.
Correspondence on ‘Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm syndrome: results of the CHIC study’
Authors: Aimilios Kaklamanos, Panagiotis Karamichalos, Panayiotis G Vlachoyiannopoulos, Athanasios G Tzioufas
Journal: Annals of the Rheumatic Diseases (2021)

<h3>Background</h3> The UK Quality and Outcomes Framework (QOF) offers financial incentives to deliver high-quality care for individual diseases, but the single-disease focus takes no account of multimorbidity. <h3>Aim</h3> To examine variation in QOF payments for two indicators incentivised in ≥1 disease domain. <h3>Design and setting</h3> Modelling study using cross-sectional data from 314 general practices in Scotland. <h3>Method</h3> Maximum payments that practices could receive under existing financial incentives were calculated for blood pressure (BP) control and influenza immunisation according to the number of coexisting clinical conditions. Payments were recalculated assuming a single new indicator. <h3>Results</h3> Payment varied by condition (£4.71–£11.08 for one BP control and £2.09–£5.78 for one influenza immunisation). Practices earned more for delivering the same action in patients with multimorbidity: in patients with 2, 3, and ≥4 conditions mean payments were £13.95, £21.92, and £29.72 for BP control, and £7.48, £11.21, and £15.14 for influenza immunisation, respectively. Practices in deprived areas had more multiple incentivised patients. When recalculated so that each incentivised action was only paid for once, all practices received less for BP control: affluent practices received more and deprived practices received less for influenza immunisation. <h3>Conclusion</h3> For patients with single conditions, existing QOF payment methods have more than twofold variation in payment for delivering the same process. Multiple payments were common in patients with multimorbidity. A payment method is required that ensures fairness of rewards while maintaining adequate funding for practices based on actual workload.
REPRODUCTIBILITY OF A METABOLITE RISK SCORE TO PREDICT CORONARY HEART DISEASE IN A MIDDLE EASTERN POPULATION
Authors: Ayman El-Menyar, Ehsan Ullah, Khalid Kunji, Reem Elsousy, Amna Al-Nesf, Nada Ali Al-Tamimi, Maryam Ali Yousef Al-Nesf, Alka Beotra, Mohammed Al-Maadheed, Vidya Mohamed-Ali, Mohamad Saad, Jassim Al Suwaidi
Journal: Journal of the American College of Cardiology (2021)
マウス肝臓におけるエタノール誘発DNA損傷およびDNA修復遺伝子のアップレギュレーションのための、NADPHオキシダーゼでなくシトクロムp450 2E1の必要性
Authors: Rusyn I, Kono H, Kosyk O, Bradford Bu
Journal: Hepatology (2003)
UNICUSPID AORTIC VALVE CONCOMITANT WITH INFECTIVE ENDOCARDITIS AND SEVERE AORTIC REGURGITATION IN A PATIENT WITH COVID-19
Authors: Gunjan S. Joshi, Hiten Patel, William Sanchez-Garcia, Haitham Mazek, Manoj Bhandari, Amudhan Jyothidasan, Divyang Patel, Amol Bahekar
Journal: Journal of the American College of Cardiology (2021)
WHOLE GENOME SEQUENCING OF A MIDDLE EASTERN COHORT REPLICATES KNOWN LOCI FOR CORONARY HEART DISEASE AND IDENTIFIES POTENTIAL NOVEL ONES
Authors: Khalid Kunji, Ayman El-Menyar, Ehsan Ullah, Iftikhar Kullo, Mohamad Saad, Jassim Al Suwaidi
Journal: Journal of the American College of Cardiology (2021)
STATIN USE AND OUTCOMES IN HOSPITALIZED PATIENTS WITH SARS-COV-2 INFECTION
Authors: Hasan Siddiqi, Jefferson Vieira, Brittany Weber, Andy Kim, Henry Rutherford, Anubodh Varshney, Ankeet Bhatt, Mandeep Mehra, Ann Woolley, Garrick Stewart
Journal: Journal of the American College of Cardiology (2021)
Transgenerational effect of mutants in the RNA-directed DNA methylation pathway on the triploid block in Arabidopsis
Authors: Zhenxing Wang, Nicolas Butel, Juan Santos-González, Lauriane Simon, Cecilia Wärdig, Claudia Köhler
Journal: Genome biology (2021)

Hybridization of plants that differ in number of chromosome sets (ploidy) frequently causes endosperm failure and seed arrest, a phenomenon referred to as triploid block. In Arabidopsis, loss of function of NRPD1, encoding the largest subunit of the plant-specific RNA polymerase IV (Pol IV), can suppress the triploid block. Pol IV generates short RNAs required to guide de novo methylation in the RNA-directed DNA methylation (RdDM) pathway. Recent work suggests that suppression of the triploid block by mutants in RdDM components differs, depending on whether the diploid pollen is derived from tetraploid plants or from the omission in second division 1 (osd1) mutant. This study aims to understand this difference.
18F-fluciclovine-PET/CT imaging versus conventional imaging alone to guide postprostatectomy salvage radiotherapy for prostate cancer (EMPIRE-1): a single centre, open-label, phase 2/3 randomised controlled trial
Authors: Ashesh B Jani, Eduard Schreibmann, Subir Goyal, Raghuveer Halkar, Bruce Hershatter, Peter J Rossi, Joseph W Shelton, Pretesh R Patel, Karen M Xu, Mark Goodman, Viraj A Master, Shreyas S Joshi, Omer Kucuk, Bradley C Carthon, Mehmet A Bilen, Olayinka A Abiodun-Ojo, Akinyemi A Akintayo, Vishal R Dhere, David M Schuster
Journal: The Lancet (2021)
ROLE OF TELEMEDICINE NETWORK PROVIDED BY PHARMACIES TO DETECT ACUTE MYOCARDIAL INFARCTION IN PATIENTS WITH CHEST PAIN DURING CORONAVIRUS PANDEMIA
Authors: Savina Nodari, Francesco Fioretti, Mariangela Piazzani, Andrea Dell’Aquila, Giuliana Cimino, Antonino Milidoni, Angelica Cersosimo, Alberto Madureri, Laura Lupi, Gianbattista Bollani, Fulvio Glisenti, Gian Franco Gensini, Francesco Gabbrielli
Journal: Journal of the American College of Cardiology (2021)
TARGETED TEMPERATURE MANAGEMENT IN OHCA WITH SHOCKABLE RHYTHM AND ABSENCE OF ST-SEGMENT ELEVATION: A SUBSTUDY OF THE COACT TRIAL
Authors: Eva Marie Spoormans, Jorrit Lemkes, Gladys Janssens, Nina van der Hoeven, Lucia Jewbali, Martijn Meuwissen, Hans Bosker, Gabe Bleeker, Georgios Vlachojannis, Pim van der Harst, Michiel Voskuil, Albertus Beishuizen, Cyril Camaro, José Henriques, Maarten Vink, Ton Heestermans, Thijs Delnoij, Gillian Jessurun, Pranobe Oemrawsingh, Marcel Gosselink, Koos Plomp, Michael Magro, Peter van de Ven, Niels Van Royen, Paul Elbers
Journal: Journal of the American College of Cardiology (2021)
ASSOCIATION BETWEEN NPC1L1 AND HMGCR GENETIC VARIANTS AND DIABETES IN PREMATURE TRIPLE-VESSEL CORONARY DISEASE
Authors: Xueyan Zhao, Xiaofang Tang, Jingjing Xu, Ru Liu, Jiawen Li, Keyong Huang, Yuejin Yang, Lei Song, Jinqing Yuan
Journal: Journal of the American College of Cardiology (2021)
Healthy Intestinal Function Relies on Coordinated Enteric Nervous System, Immune System, and Epithelium Responses
Authors: Fatima B. Saldana-Morales, Dasom V. Kim, Ming-Ting Tsai, Gretchen E. Diehl
Journal: Gut Microbes (2021)

During both health and disease, a coordinated response between the epithelium, immune system, and enteric nervous system is required for proper intestinal function. While each system responds to a number of common stimuli, their coordinated responses support digestion as well as responses and recovery following injury or pathogenic infections. In this review, we discuss how individual responses to common signals work together to support these critical functions.
ATRIAL FIBRILLATION IN YOUNG PATIENTS: ANALYSIS FROM THE JORDAN ATRIAL FIBRILLATION REGISTRY
Authors: Ramzi Tabbalat, Zaid Abdulelah, Raad Al-Muhaisen, Omran Abukhalaf, Sulafa Saffarini, Sara Althunaibat, Ayman Hammoudeh
Journal: Journal of the American College of Cardiology (2021)
Endoscopic ultrasound-guided rendezvous for extrahepatic bile duct recanalization after surgical transection
Authors: Diego Martínez-Acitores de la Mata, Lucía Zabalza, Verónica Ubieto, José Luis Moya, Juan Carrascosa, Soledad Montón, Juan J. Vila
Journal: Endoscopy (2021)

A 36-year-old woman developed jaundice, fever, and biliary leak after laparoscopic cholecystectomy. Endoscopic retrograde cholangiopancreatography (ERCP) ([Video 1]) identified massive extravasation of contrast into the peritoneum through a large fistula, without filling of the proximal biliary tract ([Fig. 1]). Cholangioscopy (SpyGlass; Boston Scientific Corp., Marlborough, Massachusetts, USA) showed the confluence between the hepatic and cystic ducts, and the peritoneal space was accessed through a complete transection of the hepatic duct ([Fig. 2]), with identification of the percutaneous surgical catheter and the liver. The proximal aspect of the transected hepatic duct could not be found with the cholangioscope. Using endoscopic ultrasound (EUS), the proximal and distal segments of the extrahepatic bile duct were identified, separated by a 1.5-cm-diameter collection. Transgastric puncture of the intrahepatic bile duct with a 22-G needle was performed, hindered by lack of duct dilation. A 0.018-inch guidewire was advanced anterogradely through the transection into the distal common bile duct and duodenum. The EUS-guided rendezvous was finally completed and an 80 × 10-mm fully covered metal stent was deployed in the subsequent ERCP ([Fig. 3]). The proximal end was placed immediately distal to the biliary confluence and the distal end into the duodenal lumen, securing bilateral biliary drainage. The patientʼs jaundice resolved within a few days, and 6 months after discharge the patient remains asymptomatic.
GENDER DISPARITY IN OUTCOMES OF PATIENTS UNDERGOING MITRACLIP THERAPY: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Chanavuth Kanitsoraphan, Jakrin Kewcharoen, Chol Techorueangwiwat, Pattara Rattanawong, Sittinun Thangjui, Somsupha Kanjanauthai
Journal: Journal of the American College of Cardiology (2021)
Screening for Hypertension in Adults
Authors: Jill Jin
Journal: JAMA (2021)

US Preventive Services Task Force; Alex H. Krist, MD, MPH; Karina W. Davidson, PhD, MASc; Carol M. Mangione, MD, MSPH; Michael Cabana, MD, MA, MPH; Aaron B. Caughey, MD, PhD; Esa M. Davis, MD, MPH; Katrina E. Donahue, MD, MPH; Chyke A. Doubeni, MD, MPH; Martha Kubik, PhD, RN; Li Li, MD, PhD, MPH; Gbenga Ogedegbe, MD, MPH; Lori Pbert, PhD; Michael Silverstein, MD, MPH; James Stevermer, MD, MSPH; Chien-Wen Tseng, MD, MPH, MSEE; John B. Wong, MD
POLYGENIC RISK SCORE FOR CORONARY ARTERY DISEASE ASSOCIATES WITH INCIDENCE OF CALCIFIC AORTIC STENOSIS
Authors: Shady Abohashem, Michael Osborne, Taimur Abbasi, Hadil Zureigat, Tawseef Dar, Ahmed Ghoneem, Muhammad Etiwy, Krishna Aragam, Sammy Elmariah, Amit Khera, Ahmed Tawakol
Journal: Journal of the American College of Cardiology (2021)
ICOSAPENT ETHYL REDUCES ISCHEMIC EVENTS IN PATIENTS WITH HIGH TRIGLYCERIDES AND LOW HIGH-DENSITY LIPOPROTEIN CHOLESTEROL LEVELS: REDUCE-IT HIGH TG/LOW HDL-C ANALYSES
Authors: Xiaowen Wang, Deepak Bhatt, Michael Miller, Ph. Gabriel Steg, Eliot Brinton, Terry Jacobson, Steven Ketchum, Rebecca Juliano, Lixia Jiao, Ralph Doyle, Craig Granowitz, Christina Copland, Jean Claude Tardif, Christie Ballantyne, Matthew Budoff, R. Preston Mason, William Boden
Journal: Journal of the American College of Cardiology (2021)
OUT-OF-HOURS SERVICE HAS NO EFFECT ON TIME TO FIRST EKG, DOES AFFECT TIME FROM EKG TO REVASCULARIZATION, IN PATIENTS WHO SELF-PRESENT TO THE EMERGENCY ROOM WITH ACUTE CORONARY SYNDROME: A REVIEW OF THE IRISH NATIONAL ACS REGISTRY
Authors: Jack J. Laffan, Hafiz Hussein, Mark Kennedy
Journal: Journal of the American College of Cardiology (2021)
The Risks and Benefits of Myopia Control
Authors: Mark A. Bullimore, Eric R. Ritchey, Sunil Shah, Nicolas Leveziel, Rupert R.A. Bourne, D. Ian Flitcroft
Journal: Ophthalmology (2021)

The prevalence of myopia is increasing around the world, stimulating interest in methods to slow its progression. The primary justification for slowing myopia progression is to reduce the risk of vision loss through sight-threatening ocular pathologic features in later life. The article analyzes whether the potential benefits of slowing myopia progression by 1 diopter (D) justify the potential risks associated with treatments.First, the known risks associated with various methods of myopia control are summarized, with emphasis on contact lens wear. Based on available data, the risk of visual impairment and predicted years of visual impairment are estimated for a range of incidence levels. Next, the increased risk of potentially sight-threatening conditions associated with different levels of myopia are reviewed. Finally, a model of the risk of visual impairment as a function of myopia level is developed, and the years of visual impairment associated with various levels of myopia and the years of visual impairment that could be prevented with achievable levels of myopia control are estimated.Assuming an incidence of microbial keratitis between 1 and 25 per 10 000 patient-years and that 15% of cases result in vision loss leads to the conclusion that between 38 and 945 patients need to be exposed to 5 years of wear to produce 5 years of vision loss. Each additional 1 D of myopia is associated with a 58%, 20%, 21%, and 30% increase in the risk of myopic maculopathy, open-angle glaucoma, posterior subcapsular cataract, and retinal detachment, respectively. The predicted mean years of visual impairment ranges from 4.42 in a person with myopia of -3 D to 9.56 in a person with myopia of -8 D, and a 1-D reduction would lower these by 0.74 and 1.21 years, respectively.The potential benefits of myopia control outweigh the risks: the number needed to treat to prevent 5 years of visual impairment is between 4.1 and 6.8, whereas fewer than 1 in 38 will experience a loss of vision as a result of myopia control.
TNF Drives AKI-to-CKD Transition Downstream of Proximal Tubule EGFR
Authors: Mai Abdelmageed, Eirini Kefalogianni, Akshayakeerthi Arthanarisami, Fatima Zohra Khamissi, Jeffrey J. Atkinson, Andreas Herrlich
Journal: Journal of the American Society of Nephrology (2021)

Abdelmageed, Mai; Kefalogianni, Eirini; Arthanarisami, Akshayakeerthi; Khamissi, Fatima Zohra; Atkinson, Jeffrey J.; Herrlich, Andreas Author Information
Polycomb Repressor Complex 2 Regulates HOXA9 and HOXA10, Activating ID2 in NK/T-Cell Lines.
Authors: Stefan Nagel, Letizia Venturini, Marquez E. Victor, Corinna Meyer, Maren Kaufmann, Michaela Scherr, Roderick A.F. MacLeod, Hans G. Drexler
Journal: Blood (2009)
SOCIOECONOMIC STATUS AND TRENDS IN ATRIAL FIBRILLATION HOSPITALIZATION IN THE UNITED STATES
Authors: Chaitanya Rojulpote, Shivaraj Patil, Karthik Gonuguntla, Manish Kumar, Srinivas Nadadur, Abhishek Achunair, Paco Bravo, Tapan Buch, Pranav Karambelkar, Purveshkumar Patel, Ajinkya Buradkar, Vijay Pratap Singh, Samir Pancholy
Journal: Journal of the American College of Cardiology (2021)