tbuckley/cabot-search huggingface dataset:
Decision Curve Analysis and the Net Benefit of Novel Tests
Authors: Adewole S. Adamson, Ivo Abraham
Journal: JAMA Dermatology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Spatial distribution and network morphology of epicardial, endocardial, interstitial, and Purkinje cell-associated elastin fibers in porcine left ventricle
Authors: Xiaodan Shi, Song Zhang, Yue Liu, Bryn Brazile, Jim Cooley, J. Ryan Butler, Sara R. McMahan, Karla L. Perez, Jiazhu Xu, Timothy Eastep, Kytai T. Nguyen, Pietro Bajona, Matthias Peltz, Huajian Gao, Yi Hong, Jun Liao
Journal: Bioactive Materials (2022)
Aberrant protein synthesis and cancer development: The role of canonical eukaryotic initiation, elongation and termination factors in tumorigenesis
Authors: Angela Rubio, Gavin D. Garland, Aristeidis Sfakianos, Robert F. Harvey, Anne E. Willis
Journal: Seminars in Cancer Biology (2022)

In tumourigenesis, oncogenes or dysregulated tumour suppressor genes alter the canonical translation machinery leading to a reprogramming of the translatome that, in turn, promotes the translation of selected mRNAs encoding proteins involved in proliferation and metastasis. It is therefore unsurprising that abnormal expression levels and activities of eukaryotic initiation factors (eIFs), elongation factors (eEFs) or termination factors (eRFs) are associated with poor outcome for patients with a wide range of cancers. In this review we discuss how RNA binding proteins (RBPs) within the canonical translation factor machinery are dysregulated in cancers and how targeting such proteins is leading to new therapeutic avenues.
Enhanced BNT162b2 vaccine-induced cellular immunity in anti-CD19 CAR T cell–treated patients
Authors: Bernice Ling Zhi Oh, Nicole Tan, Ruklanthi de Alwis, Kamini Kunasegaran, Zhiwei Chen, Michelle Poon, Esther Chan, Jenny G. H. Low, Allen Eng Juh Yeoh, Antonio Bertoletti, Nina Le Bert
Journal: Blood (2022)
Cystine uptake inhibition potentiates front-line therapies in acute myeloid leukemia
Authors: Bryann Pardieu, Justine Pasanisi, Frank Ling, Reinaldo Dal Bello, Justine Penneroux, Angela Su, Romane Joudinaud, Laureen Chat, Hsin Chieh Wu, Matthieu Duchmann, Gaetano Sodaro, Clémentine Chauvel, Florence A. Castelli, Loic Vasseur, Kim Pacchiardi, Yannis Belloucif, Marie-Charlotte Laiguillon, Eshwar Meduri, Camille Vaganay, Gabriela Alexe, Jeannig Berrou, Chaima Benaksas, Antoine Forget, Thorsten Braun, Claude Gardin, Emmanuel Raffoux, Emmanuelle Clappier, Lionel Adès, Hugues de Thé, François Fenaille, Brian J. Huntly, Kimberly Stegmaier, Hervé Dombret, Nina Fenouille, Camille Lobry, Alexandre Puissant, Raphael Itzykson
Journal: Leukemia (2022)
Nationwide hepatitis C virus screening and treatment of adolescents in Egyptian schools
Authors: Ehab Kamal, Noha Asem, Mohamed Hassany, Galal Elshishiney, Wael Abdel-Razek, Heba Said, Sohair Abdel Hamid, Tamer Essam, Ahmed Rehan, Aysam Salah, Tarek Saad, Nasr Shawky, Abdalla Mostafa, Yasser Omar, Islam Ammar, Ramy Saeed, Mohamed AbdAllah, Jean Jabbour, Alaa Hashish, Samah Bastawy, Noha El Qareh, Nahla Gamaleldin, Khaled Kabil, Wahid Doss, Manal H El-Sayed, Hala Zaid
Journal: The Lancet. Gastroenterology & hepatology (2022)
Annual Health Care Utilization and Costs for Treatment of Cutaneous and Anogenital Warts Among a Commercially Insured Population in the US, 2017-2019
Authors: Ronald Berna, David J. Margolis, John S. Barbieri
Journal: JAMA Dermatology (2022)

This cohort study evaluates annual health care utilization and costs associated with common cutaneous and anogenital wart treatments, such as cryotherapy, intralesional immunotherapy, and prescription topical treatments.
The steatosis‐associated fibrosis estimator (SAFE) score: A tool to detect low‐risk NAFLD in primary care
Authors: Pimsiri Sripongpun, W. Ray Kim, Ajitha Mannalithara, Vivek Charu, Anna Vidovszky, Steven Asch, Manisha Desai, Sun H. Kim, Allison J. Kwong
Journal: Hepatology (2022)

Background: NAFLD is common in primary care. Liver fibrosis stage 2 or higher (≥F2) increases future risk of morbidity and mortality. We developed and validated a score to aid in the initial assessment of liver fibrosis for NAFLD in primary care. Methods: Data from patients with biopsy‐proven NAFLD were extracted from the NASH Clinical Research Network observational study ( n = 676). Using logistic regression and machine‐learning methods, we constructed prediction models to distinguish ≥F2 from F0/1. The models were tested in participants in a trial (“FLINT,” n = 280) and local patients with NAFLD with magnetic resonance elastography data ( n = 130). The final model was applied to examinees in the National Health and Nutrition Examination Survey (NHANES) III ( n = 11,953) to correlate with long‐term mortality. Results: A multivariable logistic regression model was selected as the Steatosis‐Associated Fibrosis Estimator (SAFE) score, which consists of age, body mass index, diabetes, platelets, aspartate and alanine aminotransferases, and globulins (total serum protein minus albumin). The model yielded areas under receiver operating characteristic curves ≥0.80 in distinguishing F0/1 from ≥F2 in testing data sets, consistently higher than those of Fibrosis‐4 and NAFLD Fibrosis Scores. The negative predictive values in ruling out ≥F2 at SAFE of 0 were 88% and 92% in the two testing sets. In the NHANES III set, survival up to 25 years of subjects with SAFE &lt; 0 was comparable to that of those without steatosis ( p = 0.34), whereas increasing SAFE scores correlated with shorter survival with an adjusted HR of 1.53 ( p &lt; 0.01) for subjects with SAFE &gt; 100. Conclusion: The SAFE score, which uses widely available variables to estimate liver fibrosis in patients diagnosed with NAFLD, may be used in primary care to recognize low‐risk NAFLD.
Trends in location of death for individuals with primary brain tumors in the United States
Authors: Bhav Jain, Edward Christopher Dee, Urvish Jain, Ayal A Aizer, Wenya Linda Bi, Daphne Haas-Kogan, Rifaquat Rahman
Journal: Neuro-Oncology (2022)

Trends in location of death for individuals with primary brain tumors in the United StatesPrimary brain tumors are associated with severe cognitive effects on quality of life and poor overall survival.End-of-life experiences for these patients are critical 1,2 ; the majority of patients wish to die at home or in a hospice facility, whereas death in hospital settings or nursing homes may be associated with lower rates of adequate symptom management and emotional support. 3Previous literature has revealed racial and sociodemographic disparities in location of death for cancer patients. 2Therefore, we assessed trends in location of death among patients with malignant brain tumors to provide insight into these sociodemographic disparities for the neuro-oncology population.
The added value of peroral cholangioscopy to diagnose intraductal papillary neoplasm of the bile duct
Authors: Florence Anné, Christophe Snauwaert, Lieven Vandeputte, Frederik Berrevoet, Jacques Van Huysse, Jo Van Dorpe, Anne Hoorens
Journal: Endoscopy (2022)

Intraductal papillary neoplasm of the bile duct is a precursor of invasive cholangiocarcinoma [1]. Early identification and intervention may improve the poor prognosis of this disease, but diagnosis by classical imaging is often difficult [2]. Also, as surgery is the therapy of choice, a precise pre-operative evaluation is necessary [3] [4]. Cholangioscopy may contribute to the diagnostic work-up.
Response of Darier Disease Following Treatment With Baricitinib
Authors: José Manuel Busto Leis, Guillermo Servera Negre, Ander Paulo Mayor Ibarguren, Pedro Herranz Pinto
Journal: JAMA Dermatology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
The COVID-19 Pandemic Rages on for People Who Are Immunocompromised
Authors: Rita Rubin
Journal: JAMA (2022)

Brian J. Boyarsky, MD, PhD; William A. Werbel, MD; Robin K. Avery, MD; Aaron A. R. Tobian, MD, PhD; Allan B. Massie, PhD; Dorry L. Segev, MD, PhD; Jacqueline M. Garonzik-Wang, MD, PhD
Effects of early-life poverty on health and human capital in children and adolescents: analyses of national surveys and birth cohort studies in LMICs
Authors: Cesar G Victora, Fernando P Hartwig, Luis P Vidaletti, Reynaldo Martorell, Clive Osmond, Linda M Richter, Aryeh D Stein, Aluisio J D Barros, Linda S Adair, Fernando C Barros, Santosh K Bhargava, Bernardo L Horta, Maria F Kroker-Lobos, Nanette R Lee, Ana Maria B Menezes, Joseph Murray, Shane A Norris, Harshpal S Sachdev, Alan Stein, Jithin S Varghese, Zulfiqar A Bhutta, Robert E Black
Journal: The Lancet (2022)
Residential Green Space and Cognitive Function in a Large Cohort of Middle-Aged Women
Authors: Marcia P. Jimenez, Elise G. Elliott, Nicole V. DeVille, Francine Laden, Jaime E. Hart, Jennifer Weuve, Francine Grodstein, Peter James
Journal: JAMA Network Open (2022)

<h3>Importance</h3> Green space can decelerate cognitive decline by supporting physical activity, psychological restoration, or reducing exposure to air pollution. However, existing studies on the association of green space with cognitive decline are limited. <h3>Objective</h3> To examine whether residential green space was associated with cognitive function in middle-aged women. <h3>Design, Setting, and Participants</h3> Starting in 1989, the Nurses' Health Study II enrolled 116 429 female nurses aged 25 to 42 years residing in the US. In 2014 to 2016, 40 082 women were invited to complete an online cognitive battery. This cohort study analyzed women who had data on both green space exposure and cognitive measures. Data analysis was conducted from June to October 2021. <h3>Exposures</h3> Residential exposure to green space was assessed using the Normalized Difference Vegetation Index, a satellite-derived indicator of the quantity of ground vegetation. Landsat satellite data at 270-m and 1230-m buffers around each participants' residential addresses in 2013 were used. <h3>Main Outcomes and Measures</h3> In 2014 to 2016, cognitive function was measured using a self-administered online battery, the Cogstate Brief Battery, consisting of 4 tasks measuring psychomotor speed, attention, learning, and working memory; 3 composite scores, averaging together all tasks, psychomotor speed/attention, and learning/working memory, were created. In addition, the study evaluated potential mediators, including air pollution, depression, and physical activity. <h3>Results</h3> The analytical sample included 13 594 women, of whom 13 293 (98%) were White. Mean (SD) age was 61.2 (4.6) years. In models adjusted for age at assessment, race, childhood, adulthood, and neighborhood socioeconomic status, green space was associated with higher scores on the global Cogstate composite (mean difference per IQR in green space, 0.05; 95% CI, 0.02 to 0.07), and psychomotor speed/attention (mean difference in score, 0.05 standard units; 95% CI, 0.02 to 0.08). This difference in scores is similar to the difference observed in women 1 year apart in age in the data. By contrast, there was no association between green space and learning/working memory (mean difference, 0.0300; 95% CI, −0.0003 to 0.0500). <h3>Conclusions and Relevance</h3> These findings suggest that increasing residential green space may be associated with modest benefits in cognition in middle-aged women.
Continuous monitoring of surgical bimanual expertise using deep neural networks in virtual reality simulation
Authors: Recai Yilmaz, Alexander Winkler-Schwartz, Nykan Mirchi, Aiden Reich, Sommer Christie, Dan Huy Tran, Nicole Ledwos, Ali M. Fazlollahi, Carlo Santaguida, Abdulrahman J. Sabbagh, Khalid Bajunaid, Rolando Del Maestro
Journal: npj Digital Medicine (2022)

In procedural-based medicine, the technical ability can be a critical determinant of patient outcomes. Psychomotor performance occurs in real-time, hence a continuous assessment is necessary to provide action-oriented feedback and error avoidance guidance. We outline a deep learning application, the Intelligent Continuous Expertise Monitoring System (ICEMS), to assess surgical bimanual performance at 0.2-s intervals. A long-short term memory network was built using neurosurgeon and student performance in 156 virtually simulated tumor resection tasks. Algorithm predictive ability was tested separately on 144 procedures by scoring the performance of neurosurgical trainees who are at different training stages. The ICEMS successfully differentiated between neurosurgeons, senior trainees, junior trainees, and students. Trainee average performance score correlated with the year of training in neurosurgery. Furthermore, coaching and risk assessment for critical metrics were demonstrated. This work presents a comprehensive technical skill monitoring system with predictive validation throughout surgical residency training, with the ability to detect errors.
In vivo labeling reveals continuous trafficking of TCF-1+ T cells between tumor and lymphoid tissue
Authors: Zhi Li, Zewen K. Tuong, Isaac Dean, Claire Willis, Fabrina Gaspal, Rémi Fiancette, Suaad Idris, Bethany Kennedy, John R. Ferdinand, Ana Peñalver, Mia Cabantous, Syed Murtuza Baker, Jeremy W. Fry, Gianluca Carlesso, Scott A. Hammond, Simon J. Dovedi, Matthew R. Hepworth, Menna R. Clatworthy, David R. Withers
Journal: The Journal of Experimental Medicine (2022)

Improving the efficacy of immune checkpoint therapies will require a better understanding of how immune cells are recruited and sustained in tumors. Here, we used the photoconversion of the tumor immune cell compartment to identify newly entering lymphocytes, determine how they change over time, and investigate their egress from the tumor. Combining single-cell transcriptomics and flow cytometry, we found that while a diverse mix of CD8 T cell subsets enter the tumor, all CD8 T cells retained within this environment for more than 72 h developed an exhausted phenotype, revealing the rapid establishment of this program. Rather than forming tumor-resident populations, non-effector subsets, which express TCF-1 and include memory and stem-like cells, were continuously recruited into the tumor, but this recruitment was balanced by concurrent egress to the tumor-draining lymph node. Thus, the TCF-1+ CD8 T cell niche in tumors is highly dynamic, with the circulation of cells between the tumor and peripheral lymphoid tissue to bridge systemic and intratumoral responses.
The Technological Advancement to Engineer Next‐Generation Stent‐Grafts: Design, Material, and Fabrication Techniques
Authors: Ebrahim Vahabli, James Mann, Behzad Shiroud Heidari, Michael Lawrence‐Brown, Paul Norman, Shirley Jansen, Elena De‐Juan‐Pardo, Barry Doyle
Journal: Advanced Healthcare Materials (2022)

Abstract Endovascular treatment of aortic disorders has gained wide acceptance due to reduced physiological burden to the patient compared to open surgery, and ongoing stent‐graft evolution has made aortic repair an option for patients with more complex anatomies. To date, commercial stent‐grafts are typically developed from established production techniques with simple design structures and limited material ranges. Despite the numerous updated versions of stent‐grafts by manufacturers, the reoccurrence of device‐related complications raises questions about whether the current manfacturing methods are technically able to eliminate these problems. The technology trend to produce efficient medical devices, including stent‐grafts and all similar implants, should eventually change direction to advanced manufacturing techniques. It is expected that through recent advancements, especially the emergence of 4D‐printing and smart materials, unprecedented features can be defined for cardiovascular medical implants, like shape change and remote battery‐free self‐monitoring. 4D‐printing technology promises adaptive functionality, a highly desirable feature enabling printed cardiovascular implants to physically transform with time to perform a programmed task. This review provides a thorough assessment of the established technologies for existing stent‐grafts and provides technical commentaries on known failure modes. They then discuss the future of advanced technologies and the efforts needed to produce next‐generation endovascular implants.
Efficacy of Therapies for Actinic Keratosis
Authors: Rachel K. Lim, Thomas A. Trikalinos, Martin A. Weinstock
Journal: JAMA Dermatology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Interrupted subcuticular suture spacing during linear wound closures and the effect on wound cosmesis: a randomized evaluator-blinded split-wound comparative effectiveness trial
Authors: Karin Eshagh, Lindsay R. Sklar, Aunna Pourang, April W. Armstrong, Harshaan Dhaliwal, Daniel B. Eisen
Journal: British Journal of Dermatology (2022)

Abstract Background Surgical reconstructions following Mohs micrographic surgery and standard surgical excisions are often closed with two layers of sutures: a deep subcuticular layer and a superficial cuticular layer. Some surgeons feel the need to place many deep sutures in order to reduce tension on cuticular sutures, as they believe this may decrease incidence of track marks and dehiscence, and lead to better cosmetic outcomes. However, others feel that a higher number of subcuticular sutures increases the risk of a suture reaction, which leads to patient anxiety and poorer wound cosmesis. To our knowledge, there are no studies published on the effect of subcuticular suture spacing on wound cosmesis. Objectives To determine whether suturing with 1-cm interval subcuticular sutures results in better cosmetic outcomes than suturing with 2-cm interval subcuticular sutures. Methods Fifty patients were enrolled in a randomized clinical trial using a split-wound model, where half of the wound was repaired with sutures spaced 2 cm apart and the other half was repaired with sutures spaced 1 cm apart (ClinicalTrials.gov identifier NCT03327922). Both the evaluators and patients were blinded as to which side received which treatment. The scar was evaluated 3 months post-surgery by two blinded observers and the patients themselves using the Patient and Observer Scar Assessment Scale (POSAS), a validated scar assessment instrument. Results The total mean POSAS score for observers for the sides that received 1-cm interval subcuticular sutures and the sides that received 2-cm interval subcuticular sutures did not differ significantly at 3 months (P = 0·34). There was also no significant difference in the patient assessment scale score between the two sides at 3 months (P = 0·084). Conclusions We found that 1-cm suture spacing was not significantly associated with improved overall cosmetic outcome compared with 2-cm suture spacing when evaluated by blinded observers or the patients themselves. Our results support the use of either interval. What is already known about this topic? Surgeons have differing opinions on the ideal frequency of subcuticular sutures for optimizing cosmetic outcomes and minimizing suture reactions. The effect of subcuticular suture spacing on wound cosmesis has not been previously explored in the literature. What does this study add? There was no significant difference in cosmetic outcome between 1-cm suture spacing and 2-cm suture spacing when evaluated by blinded observers and patients. Dermatology surgeons can use 2-cm suture spacing for increased efficiency, without significantly different cosmetic outcomes, detected by blinded observers and patients.