tbuckley/cabot-search huggingface dataset:
Bacterial antimicrobial resistance and dermatological ramifications*
Authors: Fiorinda F. Muhaj, Saira J. George, Stephen K. Tyring
Journal: British Journal of Dermatology (2022)

The spread of COVID-19 serves as a reminder of the might of microbes in the era of modern medicine. For years, another threat has preoccupied infectious disease experts and public health officials alike: rising antimicrobial resistance (AMR). Resistance is exceeding stewardship efforts as well as the rates of new drug development and approval in the market. A dry antimicrobial pipeline is threatening regression to a preantibiotic era. While the consequences of resistance may seem far removed from daily clinical practice, awareness of AMR is essential to dermatological care given that dermatologists prescribe more antibiotics per physician than other providers. Antibiotics in dermatology are often used for prolonged courses, with significant potential for microbiome alteration and antibiotic-related adverse effects. Through this review we hope to contribute to efforts of bringing the crisis of AMR to the forefront of daily dermatological practice.
Craniopharyngioma Presenting with Acute Blindness
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Progress Toward Poliomyelitis Eradication — Nigeria, January 2014–July 2015
Authors: Andrew Etsano, Rajni Gunnala, Faisal Shuaib, Eunice Damisa, Pascal Mkanda, Johnson M. Ticha, Richard Banda, Charles Korir, Ana Elena Chevez, Ogu Enemaku, Melissa Corkum, Lora B. Davis, Gatei-wa Nganda, Cara C. Burns, Steven G.F. Wassilak, John F. Vertefeuille
Journal: MMWR Morbidity and Mortality Weekly Report (2015)

August 24-28, 2015, marks the second annual Contact Lens Health Week.In collaboration with partners from clinical, public health, industry, and regulatory sectors, CDC is promoting healthy contact lens wear and care practices to reduce the risk for eye infections and complications associated with poor contact lens hygiene.Research following outbreaks of rare but serious eye infections in the United States showed that these types of infections occur most often in contact lens wearers who do not take proper care of their contact lenses and cases.This finding signaled that action needed to be taken to promote safer contact lens wear and care.A report in this issue of MMWR provides an updated population-based estimate of the number of contact lens wearers in the United States.The report finds that there are 40.9 million contact lens wearers aged ≥18 years.It also includes results of a survey that found more than 99% of contact lens wearers report at least one contact lens hygiene habit that could put them at risk for an eye infection, with the majority of respondents reporting behaviors that can raise the risk for eye infection.Nearly one third of contact lens wearers reported ever experiencing a contact lens-related red or painful eye that required a doctor's visit.Contact lens wearers represent a significant proportion of the U.S. population, and their contact lens hygiene habits put them at risk for painful, costly eye infections that could lead to vision problems.This year's observance targets teenage contact lens wearers, who have been associated with lower contact lens compliance and higher risk for serious eye infections.Proper contact lens hygiene habits, supplies, and regular visits to the eye doctor are all essential to keeping contact lens wearers' eyes healthy.
Expanded Prenatal Testing: Maintaining a Non-Directive Approach to Promote Reproductive Autonomy
Authors: Vardit Ravitsky, Marie-Christine Roy, Julie Richer, Marie-Françoise Malo, Tierry M. Laforce, Anne-Marie Laberge
Journal: The American Journal of Bioethics (2022)

This article is referred to by:Access to Expanded Prenatal Genetic Testing: Response to Open Peer Commentaries
Twisting mice move the dystonia field forward
Authors: Åsa Petersén, Deniz Kirik
Journal: Journal of Clinical Investigation (2014)

A common form of the hyperkinetic movement disorder dystonia is caused by mutations in the gene TOR1A (located within the DYT1 locus), which encodes the ATPase torsinA. The underlying neurobiological mechanisms that result in dystonia are poorly understood, and progress in the field has been hampered by the absence of a dystonia-like phenotype in animal models with genetic modification of Tor1a. In this issue of the JCI, Liang et al. establish the first animal model with a dystonic motor phenotype and link torsinA hypofunction to the development of early neuropathological changes in distinct sensorimotor regions. The findings of this study will likely play an important role in elucidating the neural substrate for dystonia and should stimulate systematic neuropathological and imaging studies in carriers of TOR1A mutations.
Medicolegal
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Linking Structural Racism and Discrimination and Breast Cancer Outcomes: A Social Genomics Approach
Authors: Ruth C. Carlos, Samilia Obeng-Gyasi, Steven W. Cole, Bradley J. Zebrack, Etta D. Pisano, Melissa A. Troester, Lava Timsina, Lynne I. Wagner, Jon A. Steingrimsson, Ilana Gareen, Christoph I. Lee, Alyce S. Adams, Consuelo H. Wilkins
Journal: Journal of Clinical Oncology (2022)

Despite breast cancer screening rates that exceed those of White women, 26 Black women are diagnosed with more advanced stages of breast cancer.More worrisome, Black women endure higher rates of falsepositive screening results, an unfavorable outcome implicated in an increased risk of breast cancer.Additionally, elevated anxiety, stress, financial burden, [27][28][29][30][31][32] and paradoxically, reduced breast cancer screening 33
Mechanisms of motor symptom improvement by long-term Tai Chi training in Parkinson’s disease patients
Authors: Gen Li, Pei Huang, Shi-Shuang Cui, Yu-Yan Tan, Ya-Chao He, Xin Shen, Qin-Ying Jiang, Ping Huang, Gui-Ying He, Bin-Yin Li, Yu-Xin Li, Jin Xu, Zheng Wang, Sheng-Di Chen
Journal: Translational Neurodegeneration (2022)

Abstract Background Tai Chi has been shown to improve motor symptoms in Parkinson’s disease (PD), but its long-term effects and the related mechanisms remain to be elucidated. In this study, we investigated the effects of long-term Tai Chi training on motor symptoms in PD and the underlying mechanisms. Methods Ninety-five early-stage PD patients were enrolled and randomly divided into Tai Chi ( n = 32), brisk walking ( n = 31) and no-exercise ( n = 32) groups. At baseline, 6 months and 12 months during one-year intervention, all participants underwent motor symptom evaluation by Berg balance scale (BBS), Unified PD rating-scale (UPDRS), Timed Up and Go test (TUG) and 3D gait analysis, functional magnetic resonance imaging (fMRI), plasma cytokine and metabolomics analysis, and blood Huntingtin interaction protein 2 ( HIP2 ) mRNA level analysis. Longitudinal self-changes were calculated using repeated measures ANOVA. GEE (generalized estimating equations) was used to assess factors associated with the longitudinal data of rating scales. Switch rates were used for fMRI analysis. False discovery rate correction was used for multiple correction. Results Participants in the Tai Chi group had better performance in BBS, UPDRS, TUG and step width. Besides, Tai Chi was advantageous over brisk walking in improving BBS and step width. The improved BBS was correlated with enhanced visual network function and downregulation of interleukin-1β. The improvements in UPDRS were associated with enhanced default mode network function, decreased L -malic acid and 3-phosphoglyceric acid, and increased adenosine and HIP2 mRNA levels. In addition, arginine biosynthesis, urea cycle, tricarboxylic acid cycle and beta oxidation of very-long-chain fatty acids were also improved by Tai Chi training. Conclusions Long-term Tai Chi training improves motor function, especially gait and balance, in PD. The underlying mechanisms may include enhanced brain network function, reduced inflammation, improved amino acid metabolism, energy metabolism and neurotransmitter metabolism, and decreased vulnerability to dopaminergic degeneration. Trial registration This study has been registered at Chinese Clinical Trial Registry (Registration number: ChiCTR2000036036; Registration date: August 22, 2020).
ANTIRABIC INOCULATIONS AT THE PATIENT'S HOME.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Childhood Allergy and the NeOnatal Environment (CANOE) Research Protocol and Recruitment Redesign during the COVID-19 Pandemic
Authors: Tonia Afshan, Ajit Kulkarni, Talissa Blackshere, Jennifer Smith, Elizabeth Tesson, Tina Hartert, Katherine Rivera-Spoljaric, Edward Zoratti, Christine Joseph, James Gern, Anne Marie Singh
Journal: Journal of Allergy and Clinical Immunology (2022)
Inhibition of hereditary hepatitis and liver tumor development in Long-Evans cinnamon rats by the copper-chelating agent trientine dihydrochloride
Authors: K Sone, M Maeda, K Wakabayashi, N Takeichi, M Mori, T Sugimura, M Nagao
Journal: Hepatology (1996)

Trientine dihydrochloride (trientine) is an alternative medicinal copper chelating agent for patients with Wilson’s disease of penicillamine intolerance. We examined the effects of trientine on the spontaneous development of hepatitis and hepatic tumors, by its short- term and long-term administration to Long-Evans cinnamon (LEC) rats with an accumulation of copper in the liver, as animal models of Wilson’s disease. Male rats were given trientine in their drinking water at 1500 ppm for 18 weeks, from 6 weeks to 24 weeks of age in short-term experiment, and 1500 ppm for 27 weeks then 750 ppm for 52 weeks, from 8 to 87 weeks of age in the long-term experiment. Development of hepatitis was observed in the control LEC rats at 18 weeks of age. They had high levels of plasma transaminases (glutamic oxaloacetic transaminase [GOT], glutamic pyruvic transaminase [GPT]), and on pathological examination, hepatocyte destruction was observed. Histological findings revealed that short-term administration of trientine inhibited the development of hepatitis remarkably. The plasma GOT and GPT levels of treated animals were only slightly higher than those of normal LEA (Long-Evans with agouti coat color) rats, a sibling line of LEC rats. Copper levels in the liver were decreased by a maximum of 50 percent. In the long-term administration of trientine, the incidence of hepatic cell carcinoma (HCC) in the treated rats was 67 percent that of the untreated LEC rats, and the number of HCCs per rat in the treated group was 0.7 +/- 0.5, being significantly lower as compared with 4.7 +/- 3.5 in the untreated rats. Additionally, the development of cholangiofibrosis in LEC rats was completely prevented by long-term administration of the agent. The copper level in the liver of treated rats was reduced by 33 percent at 87 weeks of age. Development of HCC in LEC rats might be partly, but not totally, because of copper accumulation. No effects on the levels of copper, iron, or zinc in the liver of LEA rats was detected, and no adverse effects were detected in either LEC or LEA rats after both short- and long-term administration of trientine in drinking water.
Prevalence of Anti-lymphocyte Antibodies in Patients with Good Syndrome and Partial RAG Deficiency
Authors: Chen Wang, Boglarka Ujhazi, Ainhoa Perez Diez, Sumai Gordon, Xiangdong Liu, Manish Butte, Attila Kumanovics, Krisztian Csomos, Irini Sereti, Jolan Walter
Journal: Journal of Allergy and Clinical Immunology (2022)
Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer
Authors: Lisa Derosa, Bertrand Routy, Andrew Maltez Thomas, Valerio Iebba, Gerard Zalcman, Sylvie Friard, Julien Mazieres, Clarisse Audigier-Valette, Denis Moro-Sibilot, François Goldwasser, Carolina Alves Costa Silva, Safae Terrisse, Melodie Bonvalet, Arnaud Scherpereel, Hervé Pegliasco, Corentin Richard, François Ghiringhelli, Arielle Elkrief, Antoine Desilets, Felix Blanc-Durand, Fabio Cumbo, Aitor Blanco, Romain Boidot, Sandy Chevrier, Romain Daillère, Guido Kroemer, Laurie Alla, Nicolas Pons, Emmanuelle Le Chatelier, Nathalie Galleron, Hugo Roume, Agathe Dubuisson, Nicole Bouchard, Meriem Messaoudene, Damien Drubay, Eric Deutsch, Fabrice Barlesi, David Planchard, Nicola Segata, Stéphanie Martinez, Laurence Zitvogel, Jean-Charles Soria, Benjamin Besse
Journal: Nature Medicine (2022)
Frataxin fracas
Authors: Mireille Cossée, Victoria Campuzano, Hana Koutnikova, Kurt Fischbeck, Jean-Louis Mandel, Michel Koenig, Sanjay I. Bidichandani, Pragna I. Patel, Maria Dolores Moltè, Joaquin Cañizares, Rosa De Frutos, Luigi Pianese, Francesca Cavalcanti, Antonella Monticelli, Sergio Cocozza, Laura Montermini, Massimo Pandolfo
Journal: Nature Genetics (1997)
UNFIT FOR MILITARY SERVICE.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anti‐CD19 and anti‐BCMA CAR T cell therapy followed by lenalidomide maintenance after autologous stem‐cell transplantation for high‐risk newly diagnosed multiple myeloma
Authors: Xiaolan Shi, Lingzhi Yan, Jingjing Shang, Liqing Kang, Zhi Yan, Song Jin, Mingqing Zhu, Huirong Chang, Feiran Gong, Jiazi Zhou, Guanghua Chen, Jinlan Pan, Dandan Liu, Xiaming Zhu, Fang Tang, Minghong Liu, Wei Liu, Feirong Yao, Lei Yu, Depei Wu, Chengcheng Fu
Journal: American Journal of Hematology (2022)

Abstract Few prospective studies have examined posttransplant chimeric antigen receptor (CAR) T cell infusion as candidates for front‐line consolidation therapy for high‐risk multiple myeloma (MM) patients. This single‐arm exploratory clinical trial is the first to evaluate the safety and efficacy of sequential anti‐CD19 and anti‐BCMA CAR‐T cell infusion, followed by lenalidomide maintenance after autologous stem cell transplantation (ASCT), in 10 high‐risk newly diagnosed multiple myeloma (NDMM) patients. The treatment was generally well tolerated, with hematologic toxicities being the most common grade 3 or higher adverse events. All patients had cytokine release syndrome (CRS), which was grade 1 in 5 patients (50%) and grade 2 in 5 patients (50%). No neurotoxicity was observed after CAR‐T cell infusion. The overall response rate was 100%, with the best response being 90% for a stringent complete response (sCR), and 10% for a complete response (CR). At a median follow‐up of 42 (36–49) months, seven (70%) of 10 patients showed sustained minimal residual disease (MRD) negativity for more than 2 years. The median progression‐free survival (PFS) and overall survival (OS) were not reached. Although the sample size was small and there was a lack of control in this single‐arm study, the clinical benefits observed warrant ongoing randomized controlled trials.
This Month's Highlights
Journal: Journal of the American Society of Nephrology (2021)

### SARS-CoV-2 Antibodies in Hemodialysis A study of the antibody response to the virus (specifically, IgG against nucleocapsid and spike antigens) in 83 hemodialysis patients who recovered from coronavirus disease 2019 (COVID-19) found that most patients maintained antispike antibodies, but about
CONTEMPORARY IN-HOSPITAL OUTCOMES OF CHRONIC TOTAL OCCLUSION INTERVENTIONS UPDATE FROM THE PROGRESS-CTO (PROSPECTIVE GLOBAL REGISTRY FOR THE STUDY OF CHRONIC TOTAL OCCLUSION INTERVENTION) INTERNATIONAL REGISTRY
Authors: Evangelia Vemmou, Dimitrios Karmpaliotis, Oleg Krestyaninov, Dmitrii Khelimskii, James Choi, Farouc Jaffer, Jeffrey Moses, Nicholas J. Lembo, Manish Parikh, Ziad Ali, Ajay Kirtane, Robert W. Yeh, Mitul P. Patel, Iosif Xenogiannis, Ilias Nikolakopoulos, Michael Koutouzis, Ioannis Tsiafoutis, Barry F. Uretsky, Basem Elbarouni, Michael Love, Bavana Rangan, M. Nicholas Burke, Shuaib Abdullah, Subhash Banerjee, Emmanouil Brilakis
Journal: Journal of the American College of Cardiology (2020)
Three Allergens Subcutaneous Inmunotherapy In Polen-Allergic Patients: Our Experience
Authors: Isabel Torres Rojas, Paula López-Gonzalez, Diana Pérez-Alzate, Elisa Haroun-Díaz, Natalia Blanca-López, Maria Luisa Somoza Álvarez, Ana Prieto-Moreno Pfeifer, Maria Desamparados Cervera, Carlos Blanco Mota, María Vázquez de la Torre, Francisco Javier Ruano
Journal: Journal of Allergy and Clinical Immunology (2022)
Fish and shellfish allergy: Are they different in different countries?
Authors: Alla Nakonechna, Ard van Bergen, Ariharan Anantharachagan, Dilani Arnold, Nicole Johnston, Kari Nadeau, Chris Rutkowski, Sayantani Sindher, Panida Sriaroon, Iason Thomas, Pavaladurai Vijayadurai, Annette Wagner
Journal: Journal of Allergy and Clinical Immunology (2022)
AORTIC VALVE REINTERVENTION AFTER BALLOON AORTIC VALVULOPLASTY FOR CONGENITAL AORTIC STENOSIS: INTERMEDIATE AND LATE FOLLOW-UP
Authors: David W. Brown, Amy E. Dipilato, Erin C. Chong, James E. Lock, Doff B. McElhinney
Journal: Journal of the American College of Cardiology (2010)
Tezepelumab Treatment Reduced Asthma Symptomatic Days in Adults and Adolescents with Severe, Uncontrolled Asthma in the Phase 3 NAVIGATOR Study
Authors: Warner Carr, Neal Jain, Chris Ambrose, Nicole Clarke, Neil Martin, Kamil Kmita, Pooja Desai, Jean-Pierre Llanos-Ackert, Sandhia Ponnarambil
Journal: Journal of Allergy and Clinical Immunology (2022)
Coxiella burnetii infection may be linked to cardiovascular disease
Journal: BMJ (1999)

Community exercise classes help people with back painAlthough patients with back pain should return to normal activities as soon as possible, many are afraid of further injury or making their pain worse and therefore reduce their activities.This can lead to chronic disability.Klaber Moffett et al (p 279) show that referring patients to a progressive exercise programme of eight evening sessions led by physiotherapists helped patients to cope better with their pain and function better.The benefits were maintained for at least a year, and patients' initial preferences for type of management did not affect outcome.Coxiella burnetii infection may be linked to cardiovascular disease