tbuckley/cabot-search huggingface dataset:
Genetic characterisation of the emerging invasive Neisseria meningitidis serogroup Y in Sweden, 2000 to 2010
Authors: S Thulin Hedberg, B Törös, H Fredlund, P Olcén, P Mölling
Journal: Eurosurveillance (2011)

Neisseria meningitidis serogroups B and C have been responsible for the majority of invasive meningococcal disease in Europe. Recently, an increase of N. meningitidis disease due to serogroup Y has been noted in Sweden (in 2010, the proportion was 39%, with an incidence of 0.23 per 100,000 population), as well as in other northern European countries. We aimed to investigate the clonal pattern of the emerging serogroup Y in Sweden during 2000 to 2010. The serogroup Y isolates identified during this time (n=85) were characterised by multilocus sequence typing and sequencing of the fetA, fHbp, penA, porA and porB genes. The most frequent clone (comprising 28 isolates) with identical allele combinations of the investigated genes, was partly responsible for the observed increased number of N. meningitidis serogroup Y isolates. It was sulfadiazine resistant, with genosubtype P1.5-2,10-1,36-2, sequence type 23, clonal complex 23, porB allele 3-36, fetA allele F4-1, fHbp allele 25 and penA allele 22. The first case with disease due to this clone was identified in 2002: there was a further case in 2004, six during 2006 to 2007, eight during 2008 to 2009, with a peak of 12 cases in 2010. An unusual increase of invasive disease in young adults (aged 20–29 years) caused by this clone was shown, but no increase in mortality rate was observed.
Pitfalls in Plaque Characterization by OCT
Authors: Gijs van Soest, Evelyn Regar, Thadé P.M. Goderie, Nieves Gonzalo, Senada Koljenović, Geert J.L.H. van Leenders, Patrick W. Serruys, Anton F.W. van der Steen
Journal: JACC. Cardiovascular imaging (2011)
Prolactin in Vertebrate Function and Organization
Authors: Oscar Riddle
Journal: JNCI Journal of the National Cancer Institute (1963)

Journal Article Prolactin in Vertebrate Function and Organization Get access Oscar Riddle, Ph.D. Oscar Riddle, Ph.D. Plant City, Florida Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 31, Issue 5, November 1963, Pages 1039–1110, https://doi.org/10.1093/jnci/31.5.1039 Published: 01 November 1963 Article history Received: 03 April 1963 Published: 01 November 1963
Molecular Defects In BRCC3 Complex, a Novel Pathogenic Pathway In MDS
Authors: Dayong Huang, Hideki Makishima, Yang Du, Naoko Hosono, Wenyi Shen, Chantana Polprasert, Mikkael A. Sekeres, Bartlomiej Przychodzen, Richard A Padgett, Jarnail Singh, Kathryn M Guinta, Michael J. Clemente, Brittney Dienes, Manuel Afable, Holleh D Husseinzadeh, Sarah Mcmahon, Yogen Saunthararajah, Kenichi Yoshida, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Seishi Ogawa, Jaroslaw P. Maciejewski
Journal: Blood (2013)
Effects of recombinant human interleukin-3 on CD34-enriched normal hematopoietic progenitors and on myeloblastic leukemia cells
Authors: S Saeland, C Caux, C Favre, JP Aubry, P Mannoni, MJ Pebusque, O Gentilhomme, T Otsuka, T Yokota, N Arai
Journal: Blood (1988)
Abstract 3001: Regression of the Electrocardiographic Strain Pattern Between Baseline and One Year of Antihypertensive Treatment is Strongly Associated With Regression of Electrocardiographic Left Ventricular Hypertrophy: The LIFE Study
Authors: Peter M Okin, Lasse Oikarinen, Matti Viitasalo, Lauri Toivonen, Sverre E Kjeldsen, Markku S Nieminen, Jonathan M Edelman, Bjorn Dahlof, Richard B Devereux
Journal: Circulation (2006)
M-Ras, a Widely Expressed 29-kD Homologue of p21 Ras: Expression of a Constitutively Active Mutant Results in Factor-Independent Growth of an Interleukin-3–Dependent Cell Line
Authors: Götz R.A. Ehrhardt, Kevin B. Leslie, Frances Lee, James S. Wieler, John W. Schrader
Journal: Blood (1999)
Hospitalisation leads to functional decline in the over 70s, study finds
Authors: Judy Siegel-Itzkovich
Journal: BMJ (2015)

Two in five patients aged over 70 who are hospitalised with acute conditions are discharged with reduced functioning compared with when they were admitted, a study has found.

Staying in bed, being attached to urinary catheters unnecessarily, taking sleeping pills, and inadequate nutrition are some of the reasons for a decline in function, the researchers wrote in the Journal of the American Geriatrics Society .1

“We wanted to examine why people who come into the hospital on their feet sometimes leave in a wheelchair,” said Anna Zisberg and Efrat Shadmi and colleagues, of the University of Haifa in Israel. “A patient who is …
Marrow transplantation from HLA-identical siblings for treatment of aplastic anemia: is exposure to marrow donor blood products 24 hours before high-dose cyclophosphamide needed for successful engraftment?
Authors: R Storb, RL Prentice, M Banaji, RP Witherspoon, KM Sullivan, P Stewart, JE Sanders, M Mason, K Doney, J Deeg, RA Clift, CD Buckner, FR Appelbaum, ED Thomas
Journal: Blood (1983)
Abstract MP55: Genetic Loci Associated with Ideal Cardiovascular Health: A Meta-Analysis of Genome-wide Association Studies
Authors: Norrina B Allen, Laura Rasmussen-Torvik, Lester M Arguelles, Shih-Jen Hwang, L. Adrienne Cupples, Myriam Fornage, Alanna Morrison, Rhiannon Dodge, Martha Daviglus, Daniel Levy, Caroline Fox, Jerome Rotter, Walter Palmas, Mathew Allison, Jim Pankow, Donald Lloyd-Jones, Christopher O'Donnell
Journal: Circulation (2013)

Background: Genetic loci have been associated with individual cardiovascular risk factors; however little is known about potential genes which may be involved in overall cardiovascular (CV) health....
Lessons from a cyclist
Authors: W. H Dietz, R. Davis
Journal: BMJ (1999)

One hundred years ago the BMJ reported that “In France the bicycle has done wonders, as those who remember Paris, Fontainebleau, and the intervening districts thirty years ago can bear witness if they once more revisit that pleasant part of the world.”1 For three weeks in July the bicycle in France was, once again, the source of wonderment, as Lance Armstrong won the world's premier cycling race, the Tour de France. Armstrong's quest for victory during the gruelling event not only captured the attention of sports enthusiasts but also that of the media and the public at large, because just three years ago Armstrong was diagnosed …
Pneumococcal disease surveillance in Europe
Authors: R  G Pebody, W Hellenbrand, F D'Ancona, P Ruutu
Journal: Eurosurveillance (2006)

Pneumococcal disease (Pnc) is responsible for invasive pneumococcal disease (IPD) – mainly meningitis and septicaemia - and is an infection of public health importance in Europe. Following the licensure of an effective conjugate vaccine (PCV) in Europe, several European countries, including France, Germany, the Netherlands, Norway, Spain and the United Kingdom, are introducing universal Pnc childhood immunisation programmes. As part of a European Union (EU) funded project on pneumococcal disease (Pnc-EURO), a questionnaire was distributed in late 2003 to each of the current 25 European Union member states as well as Norway and Switzerland to get a clearer picture of national surveillance for invasive pneumococcal disease (IPD) in Europe. All respondents were contacted in 2006 and asked to provide an update to the questionnaire. Twenty two of the 27 countries targeted completed and returned the questionnaire. Four of the 22 responding countries have no reporting requirement for IPD. Eighteen countries reported a total of 27 national surveillance systems. Case definitions employed in these systems differed. Fourteen of the 18 countries reported collection of IPD strains to a single reference lab for serotyping and in 12 countries to a single laboratory for susceptibility testing. Thirteen countries undertook laboratory quality assurance. Information on age and sex were widely collected, but only 11/27 systems collected information on pneumococcal polysaccharide vaccine status, while 5/27 systems collected information on pneumococcal conjugate vaccine status. The incidence of IPD reported in each of the 18 countries ranged from 0.4 to 20/100 000 in the general population, with a total of 23 470 IPD cases reported over a 12 month period. Surveillance for IPD in Europe is very heterogeneous. Several countries lack surveillance systems. Large differences in reported disease incidence may reflect both true differences, and also variations in patient and healthcare factors, including surveillance. If IPD surveillance in Europe can be strengthened, countries will be able to make informed decisions regarding the introduction of new pneumococcal vaccines and also to monitor and compare the impact and effectiveness of new programmes.
Enriching Careers in General Practice: Building morale through personal development
Authors: S Handysides
Journal: BMJ (1994)

Once general practitioners have established themselves as principals it may seem there is little else to work for. Lack of stimulation may lead to demoralisation, and it is essential that they have other ways to continue to develop their careers. Meeting other doctors to discuss cases and problems and postgraduate education often help but many doctors want to take on extra roles. The options available include undergraduate teacher, tutor for postgraduate education, and participation in medical audit advisory groups, local medical committees, or royal college faculties. Some general practitioners work part time to allow them to fit in these activities. It may also be possible to obtain extended study leave or a sabbatical to broaden experience. Others even more practice to provide new challenges.
Phase II trial of bevacizumab plus erlotinib for patients with recurrent malignant gliomas: Final results.
Authors: S. Sathornsumetee, A. Desjardins, J. J. Vredenburgh, R. E. McLendon, J. Marcello, J. E. Herndon, J. Norfleet, S. Gururangan, H. S. Friedman, D. A. Reardon
Journal: Journal of Clinical Oncology (2010)

2055 Background: Bevacizumab has antiglioma activity as single agent and in combination with cytotoxic therapy. Erlotinib may exhibit antitumor activity in some malignant glioma (MG) patients. Bevacizumab plus erlotinib was associated with clinical benefit in several solid tumors. Here we reported the final study results of bevacizumab plus erlotinib in patients with recurrent MG. Methods: The primary endpoint was 6-month progression-free survival (PFS-6). Radiographic response, pharmacokinetics and correlative biomarkers were secondary endpoints. Erlotinib was orally administered daily at 200 mg/day for patients not on enzyme-inducing anticonvulsants (EIAC) and 500 mg/day for patients on EIAC. All patients received 10 mg/kg of bevacizumab intravenously every two weeks. Key eligibility criteria included: age ≥ 18 years; KPS ≥ 60; > 4 weeks from prior surgery, XRT or chemotherapy. Patients with either > 3 prior progressions, requirement for therapeutic anti-coagulation or acute hemorrhage on pre-treatment imaging were excluded. Results: Fifty-six (98%) patients were assessable for outcome. The PFS-6 rates were 29% for GBM and 44% for anaplastic gliomas (AG). The median overall survival was 45 weeks and 76 weeks for GBM and AG patients, respectively. Twelve (50%) GBM patients and ten (31%) AG patients experienced at least partial radiographic responses. Pharmacokinetic analyses showed no difference of erlotinib exposure between EIAC and non-EIAC groups. Rash, mucositis, diarrhea and fatigue were common but mostly grade 1-2. Serious side effects were rare and included single patients who developed either intestinal perforation, arterial thrombosis, pulmonary embolism or nasal septal perforation. Grade 3 rash was found in 39% of patients and was associated with survival benefit in GBM patients. High levels of HIF-2 alpha and VEGFR-2 in archival tumors were associated with poor survival outcome in GBM patients. Conclusions: Bevacizumab plus erlotinib was adequately tolerated in recurrent MG patients. However, the addition of erlotinib to bevacizumab did not improve progression-free survival, when historically compared with other bevacizumab-containing regimens. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Genentech Genentech Genentech
Effects of novel retinoic acid compound, 9-cis-retinoic acid, on proliferation, differentiation, and expression of retinoic acid receptor-alpha and retinoid X receptor-alpha RNA by HL-60 cells
Authors: M Kizaki, Y Ikeda, R Tanosaki, H Nakajima, M Morikawa, A Sakashita, HP Koeffler
Journal: Blood (1993)
Abstract 17436: Reporting Trends and Outcomes in ST-elevation Myocardial Infarction National Hospital Quality Assessment Programs
Authors: James M McCabe, Kevin F Kennedy, Frederic S Resnic, Robert W Yeh
Journal: Circulation (2013)

Background: For patients who undergo primary PCI (pPCI) for ST-segment Elevation Myocardial Infarction (STEMI), the door-to-balloon time is an important performance measure reported to the Centers ...
Kenneth Geoffrey Wormsley
Authors: E. B. J. Penston
Journal: BMJ (2015)

Kenneth Geoffrey Wormsley (“Ken”) was born in Bielefeld, Westphalia. When he was 9 years old, his family emigrated to England. He was educated at Leighton Park School in Reading, a public school with a reputation for academic excellence that had been founded by Quakers in 1890.

In 1945 he obtained a place at Guy’s Hospital Medical School, London, where he soon established himself as a talented medical student, winning the junior proficiency prize, the Sand-Cox prize in physiology, the Michael Harris prize in anatomy, and the Beaney prize in pathology. Three years later, he gained a BSc (Hons) in chemistry before qualifying in medicine.

After house jobs in Romford, Essex, and Enfield, Ken spent his two year period of national service in British military hospitals in Wuppertal, Hostert, and Munster, Germany.

On his return to England, in 1955, he was appointed a junior lecturer to Professor W R Spurrell at Guy’s, who was actively involved in the study of gastric …
Editors pledge support for African journals
Authors: Tessa Richards
Journal: BMJ (2002)

A group of African medical editors has set up a forum to support and strengthen medical journals in Africa.

The forum, known as FAME, will be chaired by Dr James Tumwine of Makerere University, Kampala, Uganda, who is editor of the journal African Health Sciences. FAME was set up last week at a meeting in Geneva convened by the World Health Organization to discuss how information published in African journals can be disseminated more widely.

Currently, most of the medical literature published in Africa is not widely “visible.” Difficulties in journal production, coupled with huge distribution problems, mean that dissemination within individual countries is poor and across the continent as a whole is even worse. In addition, the African Index Medicus, an online resource for African health research, has all but collapsed.

Globally, access to African journals is limited by the fact that few are indexed in Medline, although access is possible to some via African Journals On Line (www.inasp.info/ajol/) and on CD Roms via ExtraMED.

Pledges of support for the forum were made at the meeting by the WHO, the World Association of Medical Editors, the Council of Science Editors, the International Network for the Availability of Scientific Publications, the Fogarty International Centre, Latin- American medical journals online, BiomedCentral, JAMA, and the BMJ.
Dissociation and hypnotizability in posttraumatic stress disorder
Authors: D Spiegel, T Hunt, H E Dondershine
Journal: American Journal of Psychiatry (1988)

The authors compared the hypnotizability of 65 Vietnam veteran patients with posttraumatic stress disorder (PTSD) to that of a normal control group and four patient samples using the Hypnotic Induction Profile. The patients with PTSD had significantly higher hypnotizability scores than patients with diagnoses of schizophrenia (N = 23); major depression, bipolar disorder--depressed, and dysthymic disorder (N = 56); and generalized anxiety disorder (N = 18) and the control sample (N = 83). This finding supports the hypothesis that dissociative phenomena are mobilized as defenses both during and after traumatic experiences. The literature suggests that spontaneous dissociation, imagery, and hypnotizability are important components of PTSD symptoms.
Pandemic influenza A(H1N1)v viruses currently circulating in New Zealand are sensitive to oseltamivir
Authors: R J Hall, M P Peacey, J C Ralston, J Bocacao, M Ziki, W Gunn, A Quirk, Q S Huang
Journal: Eurosurveillance (2009)

New Zealand, like other southern hemisphere countries with a temperate climate, has been in the winter period with seasonal influenza activity. New Zealand has also experienced a dramatic increase in the number of cases of pandemic influenza A(H1N1)v virus. Early reports from the northern hemisphere at the beginning of the pandemic showed that the virus was sensitive to the antiviral drug oseltamivir. In this study we report that pandemic influenza A(H1N1)v viruses currently circulating in New Zealand are sensitive to oseltamivir, but seasonal influenza A(H1N1) viruses – the co-circulating predominant seasonal strain, is resistant to oseltamivir.
Abstract 839: A Common Allele at the <i>GRB14</i> Locus is Associated with Increased Cardiovascular Risk in Type 2 Diabetes: Evidence from a Pooled DNA GWA Study
Authors: Rui Xu, Joanna Wojcik, Ernest V Gervino, Thomas H Hauser, Celeste A Amundsen, Christine Powers, Brian P Matthews, James H Warram, Alessandro Doria
Journal: Circulation (2008)

Genetics factor have long been recognized as important modulators of the risk of coronary artery disease (CAD) in both the general and the diabetic population. Evidence from our group indicates that some of these genes may act synergistically with the diabetic milieu, resulting into an especially strong effect among diabetic individuals. To search the genome for variants having a major effect on CAD risk in type 2 diabetes (T2D), we conducted a 300K SNP genome-wide association (GWA) study using DNA pools made from 322 CAD-positive and 412 CAD-negative individuals with T2D of European origin from the Joslin Heart Study (JHS). SNPs associated with CAD were found to cluster on chromosomes 2q24, 5p14, 9p21, and 14q31. These association signals were confirmed by genotyping of individual DNA samples, with additive ORs in the 1.4–1.6 range. The signal on chromosome 9p21 corresponded to the CAD locus that had been identified in the general population in the vicinity of the CDKN2A/CDKN2B genes. Of the other three regions emerging from the GWA screen, chromosome 2q24 showed the strongest association with CAD. The most representative SNP at this location (rs631871, additive OR=1.53, 95%CI=1.24–1.88, p=7.5 × 10 −5 ) was placed in the 3′ flanking region of the Growth Factor Receptor-Bound 14 ( GRB14 ) gene, which codes for an adapter protein with inhibitory effects on insulin receptor signaling. A similar association was found between rs631871 and cardiovascular mortality in an independent group of 475 type 2 diabetic patients (mean age at baseline=57±10 y) who were recruited at the Joslin Clinic for genetic studies in 1994–1996. In this cohort, the cumulative 10-year cardiovascular mortality was 28.1% among homozygotes for the risk allele, 20.0% among heterozygotes, and 15.8% among homozygotes for the protective allele (age and sex adjusted additive HR=1.41, 95%CI 1.04–1.90, p=0.026). By contrast, the association with increased cardiovascular risk was not confirmed in this cohort for the signals on 5p14 and 14q31. These findings point to the insulin signaling inhibitor GRB14 as a possible modulator of cardiovascular risk among individuals with T2D.
Guide to Hospitals
Authors: Martha E. Stone
Journal: BMJ (1967)

Guide to Hospitals. Washington, D.C.: Consumers' Checkbook (Center for the Study of Services), 2002. www.checkbook.org/hospital. $19.95 for two years of online access. Guide to Top Doctors. Washington, D.C.: Consumers' Checkbook (Center for the Study of Services), 2002. www.checkbook.org/cgi-bin/health/topdoctors/ default.cfm. $19.95 for two years of online access. Requirements: Internet Explorer 4.0 or higher, AOL 4.0 or higher, or Netscape 5.0 or higher. The Center for the Study of Services is, per its Web site, an independent, nonprofit consumer organization founded in 1974 with the help of funding from the U.S. Office of Consumer Affairs. Supported entirely by subscriptions, donations, and fees, it does not accept advertising. It publishes a number of guides including the two under review. There are a number of free Web sites that rate hospitals, including U.S. News and World Report (www. usnews.com/usnews/nycu/health/ho sptl/tophosp.htm), which ranks 205 medical centers. The American Hospital Directory (www.ahd.com) contains rating information for more than six thousand hospitals, but detailed reports are available by subscription only, at a cost of $395 per year for a single-user license. The Leapfrog Group (www.leapfroggroup.org) rates hospitals on three quality measures and contains information on only 672 hospitals. Free information on hospital quality will soon be available via Medicare (www.medicare.gov). Guide to Hospitals is a very easy-to-use site that rates 4,500 American acute care hospitals. It includes comparisons by death or adverse outcome from more than twenty types of procedures, and diagnoses include kidney failure, stroke, and heart attack; a rating of more than 1,300 acute care hospitals for such topics as high-risk delivery and low-risk adult surgery; JCAHO (Joint Commission on the Accreditation of Healthcare Organizations) scores; and a detailed report on each hospital including accreditation, medical school affiliation, and number of beds. The user starts by either displaying all hospitals within a two- to seventy-five-mile radius of any zip code, or if a broader geographic range is desired, choosing to compare hospitals in different parts of the country (including U.S. territories), and then as many hospitals as desired. Listings can be sorted in a variety of ways including alphabetically or by scores in such categories as Desirability Scores for High-Risk Delivery of a Baby or Desirability Scores for Complex Adult Medical Care. …