tbuckley/cabot-search huggingface dataset:
ISCHEMIC COLITIS AFTER COVID MRNA VACCINE
Authors: K. Mönkemüller, E. Abdulalleyava, K. Manovski, M. Cacho-Díaz
Journal: Endoscopy (2022)

An 82-year female patient was admitted with abdominal pain and hematochezia 7 days after her second mRNA vaccination (BioNTech, Germany). There was severe abdominal tenderness and leukocytosis (18,000). Abdominal ultrasound revealed massive edema of the colon but no atherosclerosis of the aorta. Sigmoidoscopy revealed deep ulcers luminal narrowing and frank mucosal necrosis starting at the rectosigmoid and extending into the entire sigmoid colon. Extensive evaluation including stool cultures, histology, studies for viral and autoimmune diseases did not reveal any other cause for the ischemic colitis. Thrombosis after mRNA may occur in the setting of vaccine-induced thrombocytopenia, vasculitis autoimmune or thrombosis.
STOOL-BASED TESTING TO REDUCE THE NUMBER OF UNNECESSARY SURVEILLANCE COLONOSCOPIES: THE MOCCAS STUDY
Authors: B. Carvalho, W. de Klaver, F. van Wifferen, M. van Lanschot, A.J.P. van de Wetering, Q.E.W. van der Zander, G.M. Lemmens, A.S. Bolijn, M. Tijssen, P. Delis-van Diemen, N. Buekers, K. Daenen, J. van der Meer, P.G. van Mulligen, B. Hijmans, S. de Ridder, R.W.M. van der Hulst, J.P. Kuijvenhoven, A.-M. van Berkel, A.C.T.M. Depla, M.E. van Leerdam, J.M. Jansen, C.A. Wientjes, J.W.A Straathof, E.T.P. Keulen, D. Ramsoekh, L.M.G. Moons, B.M. Berger, G.P. Lidgard, M. Zacherl, A.A.M. Masclee, M.J.E. Greuter, V.M.H. Coupé, M. van Engeland, E. Dekker, G.A. Meijer
Journal: Endoscopy (2022)

Aims The yield of colonoscopy surveillance after colorectal cancer screening is limited. To lower patient burden and healthcare costs, there is a need to reduce colonoscopies in which no advanced neoplasia is detected. The MOlecular stool testing for Colorectal CAncer Surveillance (MOCCAS) study evaluated whether stool-based testing could safely reduce the number of surveillance colonoscopies.
AN ASSESSMENT OF THE COMPLIANCE WITH THE UPPER GASTROINTESTINAL BLEED CARE BUNDLE IN AN INPATIENT SETTING WITH DAILY ENDOSCOPY LISTS
Authors: C. Rhead, H. Light, K. Besherdas
Journal: Endoscopy (2022)

Aims To assess whether the British Society of Gastroenterology Upper Gastrointestinal Bleed (UGIB) bundle [1] was being followed in a centre with access to emergency endoscopy lists between monday-friday.
DEEP LEARNING AND DIGITAL SINGLE-OPERATOR CHOLANGIOSCOPY (DSOC): AUTOMATIC DIAGNOSIS OF MALIGNANCY STATUS AND MORPHOLOGICAL CHARACTERIZATION OF BILIARY STRICTURES
Authors: J.P. Afonso, M. Mascarenhas, T. Ribeiro, J. Ferreira, F. Vilas-Boas, P. Pereira, G. Macedo
Journal: Endoscopy (2022)

Aims Patients with indeterminate biliary strictures (BS) constitute a significant diagnostic challenge. DSOC has enabled morphologic characterization and guided biopsies. However, the diagnostic yield of DSOC remains suboptimal, and the characterization of these lesions has significant interobserver variability.
SMALL BOWEL CLEANSING ASSESSMENT AND REPORT (SB-CLEAR): STANDARDIZING THE REPORT OF BOWEL PREPARATION’S QUALITY IN CAPSULE ENDOSCOPY
Authors: V. Macedo Silva, T. Lima Capela, M. Freitas, R. Sousa Magalhães, C. Arieira, S. Xavier, P. Boal Carvalho, B. Rosa, M.J. Moreira, J. Cotter
Journal: Endoscopy (2022)

Aims Small-bowel (SB) cleansing is crucial to assess reliability of capsule endoscopy (CE) findings. However, the existence of multiple grading scales for SB preparation in CE hampers their appliance in clinical practice. In 2020, Colon CLeansing Assessment and Report (CC-CLEAR) was created. We sought to validate an adapted version for evaluation of SB cleansing, aiming to standardize CE reporting regarding quality of preparation.
RECURRENCE AFTER ILEOCOLIC RESECTION IN CROHN´S DISEASE: THE PERFORMANCE OF RUTGEERTS SCORE
Authors: S. Zaouga, M. Zakhama, F. Zine El Abidine, A. Guediche, M. Abdelwahed, R. Baklouti, W. Bouhlel, N. Ben Chaabane, L. Safer
Journal: Endoscopy (2022)

Aims The aim of this study was to evaluate the performance of Rutgeerts score for predicting disease recurrence and treatment adjustment in CD patients.
MANAGEMENT OF CHOLANGIOHYDATIDOSIS WITH ENDOSCOPIC RETROGRADE CHOLANGIOGRAPHY
Authors: A. Volkanovska Nikolovska, U. Isahi, D. Nikolova, E. Nikolovska Trpchevska, M. Trajkovska
Journal: Endoscopy (2022)

A serious complication of hepatic hydatid disease is intrabiliary rupture (IBR). We present a 19-year-old male patient with acute cholangitis. His abdominal ultrasound (US) revealed multiple liver cystic lesions, two of which large and partially collapsed, and impaction of membranes into common bile duct. Endoscopic biliary drainage resulted in significantly improved patient’s condition, with control US disclosing complete evacuation of one of the large collapsed liver cysts. Endoscopic retrograde cholangiopancreatography as a minimally invasive procedure has become preferred approach of IBR management, with remarkable success rates, and additional advantage of permitting elective surgery, associated with decreased morbidity and mortality.
THE ACCURACY OF HUMAN DETECTION OF SUBMUCOSAL INVASIVE CANCER – ANALYSIS OF 739 INDIVIDUAL ASSESSMENTS OF LARGE NON-PEDUNCULATED COLORECTAL POLYPS USING A NOVEL CLINICAL DECISION TOOL
Authors: L. Debels, C. Schoonjans, J. Anderson, R. Valori, L. Desomer, D. Tate
Journal: Endoscopy (2022)

Aims Current tools to detect submucosal invasive cancer (SMI) within large (>=20mm) non-pedunculated colorectal polyps (LNPCPs) are complex. This potentially leads to incorrect decision-making (e.g. piecemeal resection of SMI necessitating surgery or surgery for benign disease).
REAL-TIME COMPUTER AIDED DETECTION OF SOLID FOCAL PANCREATIC MASSES IN ENDOSCOPIC ULTRASOUND IMAGING BASED ON CONVOLUTIONAL NEURAL NETWORKS
Authors: A.L. Udristoiu, C.E. Constantinescu, I.M. Cazacu, L.G. Gruionu, G. Gruionu, A.V. Iacob, D.E. Burtea, A. Constantin, N. Podina, N. Bejinariu, S. Udristoiu, V. Surlin, C. Copaescu, A. Saftoiu
Journal: Endoscopy (2022)

Aims Endoscopic ultrasound (EUS) imaging has a high accuracy for detection of solid focal pancreatic masses. However, the learning curve to master EUS is prolonged. The aim of our pilot project was to develop a real-time deep learning system used to detect and differentiate solid focal pancreatic masses as compared to normal pancreas.
DISEASE COURSE OF SEGMENTAL COLITIS ASSOCIATED TO DIVERTICULOSIS
Authors: E. Sinagra, R. Alloro, M. Maida, F. Rossi, G. Conoscenti, S. Testai, M. Marasà, S. Cristofalo, P. Purpura, A. Calandra, G. Pompei, R. Genova, D. Taormina, S. Di Ganci, I. Tarantino, D. Raimondo
Journal: Endoscopy (2022)

Aims This study aims to provide new data about the prevalence and the disease course of segmental colitis associated with diverticulosis (SCAD)
THE ROLE OF ENDOSCOPIC ULTRASOUND FINE-NEEDLE ASPIRATION (EUS-FNA) IN THE DIAGNOSIS OF MEDIASTINAL NODAL DISEASE
Authors: I. Budimir, T. Pavić, N. Baršić, D. Bakula, S. Pelajić, Z. Juroš, I. Vulić, D. Hrabar
Journal: Endoscopy (2022)

Aims EUS-FNA should be the first choice in diagnosis of mediastinal nodal disease after suspicious findings on CT or PET. Primary goal was confirmation of distribution mediastinal nodal disease considering on age, sex, node lenght and elastography, while secondary goal was determination of sensitivity, specificity and accuracy of the method in enlarged mediastinal lymph nodes.
AUTOMATED MEASUREMENT OF COLONOSCOPY WITHDRAWAL TIME USING CONVOLUTIONAL NEURAL NETWORKS
Authors: R. Kader, T.d. Carvalho, Y. Oh Ga, P. Brandao, S.-P. Leung, D. Toth, R. Vega, E. Seward, P. Mountney, D. Stoyanov, L.B. Lovat
Journal: Endoscopy (2022)

Aims Withdrawal time (WT) is defined as the time taken from reaching the caecum to exiting the anal canal minus time spent cleaning and performing interventions. Recent years has demonstrated the potential of artificial intelligence (AI) to detect caecal landmarks, however, its ability to detect phases of withdrawal is unexplored.
ARTIFICIAL NEURAL NETWORK FOR THE PREDICTION OF MORTALITY IN PATIENTS PRESENTED WITH NON-VARICEAL UPPER GASTROINTESTINAL BLEEDING
Authors: B.S. Ungureanu, A. Saftoiu, A. Turcu-Stiolica, S.M. Cazacu, D.I. Gheonea
Journal: Endoscopy (2022)

Aims Upper gastrointestinal bleeding (UGIB) represents a common cause of gastroenterological admission and usually requires risk stratification for level of care determination as well as a rapid decision management. The aim of our study is to assess the use of an artificial neuronal network (ANN) that may help predict mortality in patients which present with non-variceal UGIB.
ENDOSCOPIC ULTRASOUND-GUIDED ANGIOTHERAPY USING COIL AND CYANOACRYLATE GLUE FOR THE MANAGEMENT OF VISCERAL ARTERY PSEUDOANEURYSMS IN PATIENTS OF PANCREATITIS: A SAFE AND EFFECTIVE TECHNIQUE
Authors: J. Samanta, J. Dhar, C.L. Birda, H.S Mandavdhare, P. Gupta, U. Gorsi, K.H. Kumar, V. Gupta, R. Kochhar
Journal: Endoscopy (2022)

Aims Visceral artery pseudoaneurysms (PSA) can develop in patients with acute (AP) and chronic pancreatitis (CP) and EUS-guided angioembolisation (EUS-A) using coil and glue injection is a relatively newer modality with limited experience. This study aimed at studying the safety and efficacy of this modality for management of PSA in AP/CP patients.
INCIDENCE OF EARLY ONSET COLORECTAL CANCER AND ADVANCED NEOPLASIA DOES NOT HAVE MALE PREDOMINANCE – RETROSPECTIVE OBSERVATIONAL STUDY
Authors: I. Mikoviny Kajzrlikova, P. Vitek, P. Klvana, J. Kuchar, J. Platos, J. Chalupa
Journal: Endoscopy (2022)

Aims To assess the real-life incidence of early onset colorectal cancer and advanced neoplasias in a single non-university endoscopic center.
Artificial intelligence in endoscopy: transition from academic development to integration into daily endoscopic practice
Authors: A. Jeroen de Groof
Journal: Endoscopy (2022)

Over the past decade we have seen a rapid increase in the use of artificial intelligence (AI) systems in the endoscopic literature, most of which has been focused on colonic applications. The field is now moving forward rapidly, with implementation of the first clinical studies and an expansion of the research focus to a variety of endoscopic applications. Given its subtle endoscopic appearance and the corresponding diagnostic challenge, early gastric cancer is a logical application of AI. Several systems have recently been described, mainly focusing on primary detection systems [1] [2] [3].
LOW POWER FORCED COAGULATION OF LARGER VESSELS WITH ESD KNIFE REDUCES HEMOSTATIC FORCEPS USE DURING ENDOSCOPIC SUBMUCOSAL DISSECTION (ESD) AND PERORAL ENDOSCOPIC MYOTOMY (POEM)
Authors: N. Baršić, I. Budimir, D. Hrabar
Journal: Endoscopy (2022)

Aims Precoagulation of larger vessels is important in preventing bleeding and reducing operative time of third-space endoscopy procedures. Coagulation forceps is traditionally used for that purpose, requiring repeated device exchange. Precoagulation method using low power forced coagulation with ESD knife has been described by Japanese authors. Our study evaluated efficacy of 1-10 forced precoagulation during ESD and POEM procedures and its influence on coagulation forceps use.
101P Proteome and RNA-Seq changes in breast cancer patients with higher levels of progesterone receptor A than B after mifepristone treatment
Authors: A.M. Elia, J. Sanchez, P. Rojas, L. Saldain, P. Martínez Vazquez, J. Burruchaga, E.A. Spengler, I. Caillet Bois, M.D. Liguori, H. Gass, M. Abba, J. Muñoz, L. Helguero, C.C. Lanari
Journal: Annals of Oncology (2022)
LBA3 Patritumab deruxtecan (HER3-DXd) in early-stage HR+/HER2- breast cancer: Final results of the SOLTI TOT-HER3 window of opportunity trial
Authors: A. Prat, C. Falato, L. Pare Brunet, O. Martinez Saez, J.M. Cejalvo Andujar, M. Margeli Vila, P. Tolosa, F.J. Salvador Bofill, J. Cruz Jurado, B. Gonzalez-Farre, E. Sanfeliu Torres, E.M. Ciruelos, M. Espinosa-Bravo, Y. Izarzugaza Peron, S. Pernas Simon, S. Esker, P-D. Fan, J.M. Ferrero Cafiero, T. Pascual, M. Oliveira
Journal: Annals of Oncology (2022)
PERFORATION DURING DIAGNOSTIC COLONOSCOPY: OTSC AND DECOMPRESSIVE AIR PARACENTESIS FOR SUCCESSFUL RESOLUTION
Authors: A Martins Pinto da Costa, D de Frutos Rosa, M Gonzalez-Haba Ruiz, J Santiago Garcia, B Agudo Castillo, E Santos Pérez, S Blanco Rey, I El Hajra Martinez, A Garrido Botella, A Herreros de Tejada Echanojauregui
Journal: Endoscopy (2022)

Iatrogenic perforation during diagnostic colonoscopy is a rare complication (0.03-0.8%). A 77-year-old man with myelodysplastic syndrome is scoped for melena. During colonoscope insertion, sigmoid transmural perforation occurs. Given the poor manoeuvrability and the risk of complete collapse of the intestinal lumen, a 0.035” guidewire is progressed proximally. Secondly, using an OTSC clip and the twin grasper (Ovesco​), transmural defect is closed. Then, decompressive air paracentesis is performed reducing pneumoperitoneum. Although marginal, the risk of perforation during diagnostic colonoscopy exists. OTSC clips are useful in these scenarios. Decompressive air paracentesis helps controlling secondary pneumoperitoneum.
EFFECTIVENESS AND SAFETY OF 1L PEG-ASC VERSUS STANDARD BOWEL PREPARATIONS FOR COLONOSCOPY: A META-ANALYSIS
Authors: M. Maida, M. Ventimiglia, A. Vitello, E. Sinagra
Journal: Endoscopy (2022)

Aims This meta-analysis aims to estimate the effectiveness of 1L polyethylene glycol plus ascorbate (PEG-ASC) versus other bowel preparations for colonoscopy.
FOCAL CRYOBALLOON ABLATION WITH 8SEC DOSE HAS SIMILAR EFFICACY AS 10SEC FOR TREATMENT OF BARRETT’S ESOPHAGUS RELATED NEOPLASIA
Authors: C.N. Frederiks, A. Overwater, L. Alvarez Herrero, A. Alkhalaf, B.E. Schenk, A. Repici, J.J. Bergman, R.E. Pouw, R. Bisschops, R.J. Haidry, T. Beyna, H. Neuhaus, B.L.A.M. Weusten
Journal: Endoscopy (2022)

Aims Focal cryoballoon ablation (FCBA) is currently investigated for treatment of Barrett’s esophagus (BE) related neoplasia in a European multicenter study (Euro-Coldplay; NTR NL7253). After inclusion of 28/107 patients, the initial dose of 10sec was lowered to 8sec. In this current study, we compared the efficacy and safety of single FCBA treatment with 10sec versus 8sec in patients with limited BE (C≤2/M≤5).
HEMOSTATIC POWDER SPRAY – A GOOD OPTION TO PREVENT BLEEDING AFTER ENDOSCOPIC SUBMUCOSA DISSECTION?
Authors: I. Garrido, R. Morais, M. Marques, G. Macedo
Journal: Endoscopy (2022)

Aims Endoscopic submucosal dissection (ESD) has been recommended as a standard treatment for gastrointestinal neoplasms and can provide excellent long-term survival. However, post-ESD bleeding is a severe adverse event. The aim of this study was to investigate whether hemostatic powder spray (hemospray) can prevent post-ESD bleeding.
ENDOSCOPIC VACUUM THERAPY FOR THE TREATMENT OF LEAKS OR FISTULAS POST BARIATRIC SURGERY: A SYSTEMATIC REVIEW AND META –ANALYSIS
Authors: J.M. Vera Intriago, F.X. Hinostroza Duenãs, C. Flaksbaum Moll, M.F. Shinin Merchan, E.S. Do Monte Junior, I. Mendonça Proença, W. Marques Bernardo, D.T. Hourneaux De Moura, E.G. Hourneaux De Moura
Journal: Endoscopy (2022)

Aims The aim of this study is to perform a systematic review and meta-analysis to investigate the efficacy and safety of EVT in the treatment of leaks and fistulas after bariatric surgery.
Measuring the effects of COVID-19-related disruption on dengue transmission in southeast Asia and Latin America: a statistical modelling study
Authors: Yuyang Chen, Naizhe Li, José Lourenço, Lin Wang, Bernard Cazelles, Lu Dong, Bingying Li, Yang Liu, Mark Jit, Nikos I Bosse, Sam Abbott, Raman Velayudhan, Annelies Wilder-Smith, Huaiyu Tian, Oliver J Brady
Journal: The Lancet Infectious Diseases (2022)
Linguistic features of suicidal thoughts and behaviors: A systematic review
Authors: Stephanie Homan, Marion Gabi, Nina Klee, Sandro Bachmann, Ann-Marie Moser, Martina Duri', Sofia Michel, Anna-Marie Bertram, Anke Maatz, Guido Seiler, Elisabeth Stark, Birgit Kleim
Journal: Clinical Psychology Review (2022)

Language is a potential source of predictors for suicidal thoughts and behaviors (STBs), as changes in speech characteristics, communication habits, and word choice may be indicative of increased suicide risk. We reviewed the current literature on STBs that investigated linguistic features of spoken and written language. Specifically, we performed a search in linguistic, medical, engineering, and general databases for studies that investigated linguistic features as potential predictors of STBs published in peer-reviewed journals until the end of November 2021.We included 75 studies that investigated 279,032 individuals with STBs (age = 29.53 ± 10.29, 35% females). Of those, 34 (45%) focused on lexicon, 20 (27%) on prosody, 15 (20%) on lexicon and first-person singular, four (5%) on (morpho)syntax, and two (3%) were unspecified. Suicidal thoughts were predicted by more intensifiers and superlatives, while suicidal behaviors were predicted by greater usage of pronouns, changes in the amount of verb usage, more prepend and multifunctional words, more nouns and prepositions, and fewer modifiers and numerals. A diverse field of research currently investigates linguistic predictors of STBs, and more focus is needed on their specificity for either suicidal thoughts or behaviors.
ANALYZING EFFECTIVENESS AND SAFETY OF BOWEL PREPARATION USING SAME-DAY PICOSOLUTION AND BISACODYL
Authors: J.Y. Yoon, E.S. Kim, H.J. Chun, Y.T. Jeen, B. Keum, H.S. Choi
Journal: Endoscopy (2022)

Aims Since PS/MC and BIS/PEG has lesser volume to intake, the patient's compliance is high and the usage rate is increasing.Concerning about electrolyte imbalance, usually a split-dose regimen was used,in which whichever preparation was taken in the evening of the previous day and in the morning of the procedure. However, the patients’ quality of sleep decrease, nowadays the idea of same day-PS/MC and same day-BIS/PEG is emerging as alternative method.
COLORECTAL CANCER SCREENING IN PATIENTS BETWEEN 45-49 YEARS OLD: IS IT WORTHWHILE?
Authors: J. Revés, C. Nascimento, B. Morão, C. Frias Gomes, N. Abreu, L. Glória, A. Ferreira
Journal: Endoscopy (2022)

Aims Colorectal cancer (CRC) incidence is rising in young adults and recent US guidelines recommend CRC screening in individuals between 45-49yo. We aim to assess the utility of CRC screening colonoscopy in a younger Portuguese population.
EUS- GUIDED RENDEZVOUS TECHNIQUE VERSUS PRECUT PAPILLOTOMY AS SALVAGE TECHNIQUE IN PATIENTS OF BENIGN BILIARY DISEASE WITH DIFFICULT BILIARY CANNULATION: A RANDOMIZED CONTROLLED TRIAL
Authors: A. Choudhury, J. Samanta, G. Muktesh, J. Dhar, A. Kumar, J. Shah, P. Gupta, V. Gupta, T.d. Yadav, R. Kochhar
Journal: Endoscopy (2022)

Aims Standard salvage technique used for difficult bile duct cannulation (DBDC) is pre-cut papillotomy (PcP), while endoscopic ultrasound-guided rendezvous technique (EUS-RV) is a relatively newer modality. Prospective comparative data between these two techniques as salvage for biliary access in patients of benign biliary disease with DBDC is lacking and hence, this study was planned.
HIGH-RESOLUTION IMPEDANCE MANOMETRY METRICS OF THE EG-JUNCTION FOR PREDICTING CLINICAL RESPONSE FOLLOWING PERORAL ENDOSCOPIC MYOTOMY IN ACHALASIA
Authors: K. Gröhl, A. Ebigbo, E. Schnoy, H. Messmann, S. Nagl
Journal: Endoscopy (2022)

Aims Peroral endoscopic myotomy (POEM) is an effective treatment for achalasia. There is still controversy, which method is the best to predict clinical response following POEM. We aimed to evaluate changes at esophagogastric junction pressure (EGJP) and integrated relaxation pressure (IRP4) in high resolution manometry (HRM) in patients with achalasia before and after POEM as indicators for treatment response.
SMALL BOWEL EXPLORATION WITH CAPSULE ENDOSCOPY, DOES THE INDICATION FIT THE CLINICAL PRACTICE GUIDELINES?
Authors: M.M. Díaz Alcázar, A. García Robles
Journal: Endoscopy (2022)

Aims To assess if the indications of the capsule endoscopy made in our center adjust to the recommendations of the clinical practice guidelines (ESGE, 2015).
ENDOSCOPIC DILATATION OF ESOPHAGEAL STRICTURE IN A YOUNG ADULT WITH EPIDERMOLYSIS BULLOSA DYSTROPHICA
Authors: A. Pappa, T. Florou, A. Manolakis
Journal: Endoscopy (2022)

Aims A 26-year-old patient with a history of epidermolysis bullosa, visited our department due to gradually worsening dysphagia, mainly in solid foods, with multiple episodes of bolus infractions within a year.
REAL-TIME ARTIFICIAL INTELLIGENCE (AI)-AIDED ENDOSCOPY IMPROVES ADENOMA DETECTION RATES EVEN IN EXPERIENCED ENDOSCOPISTS – A COHORT STUDY IN SINGAPORE
Authors: F. Koh, J. Ladlad, C.-L. Lin, E.-K. Teo, F.-J. Foo, SK H Endoscopy Centre
Journal: Endoscopy (2022)

Aims Colonoscopy is a mainstay to detect premalignant neoplastic lesions in the colon. Real-time Artificial Intelligence (AI)-aided colonoscopy purportedly improves the polyp detection rate, especially for small flat lesions. The aim of this study is to evaluate the performance of real-time AI-aided colonoscopy in the detection of colonic polyps.
DETECTION OF GASTRIC PREMALIGNANT CONDITIONS AMONG NON-EXPERT ENDOSCOPISTS ON OPTICAL DIAGNOSIS USING A NEW VIRTUAL CHROMOENDOSCOPY DEVELOPED BY SONOSCAPE
Authors: P.G. Delgado-Guillena, G. Vinagre-Rodríguez, V. Sanchez-Jara, A. Henao-Carrasco, J.L. Gutierrez-Cierco, S. Pabón-Carrasco, J.A. Borrallo-Cruz, E. García-Martos, H. Córdova, G. Fernández- Esparrach
Journal: Endoscopy (2022)

Aims Endoscopic recognition of gastric premalignant conditions (GPC) is the first step before taking biopsies. High-definition (HD) endoscopes and virtual chromoendoscopy (VC) improve the detection of GPC. We aimed to evaluate the diagnostic accuracy for GPC among non-expert endoscopists.
No efficacy of anti-IL-23 therapy for axial spondyloarthritis in randomised controlled trials but in post-hoc analyses of psoriatic arthritis-related ‘physician-reported spondylitis’?
Authors: Juergen Braun, Robert BM Landewé
Journal: Annals of the Rheumatic Diseases (2021)

The three monoclonal antibodies ustekinumab, guselkumab and risankizumab targeting the p 40 or the 19 subunit of interleukin -23 have now been approved for the indication psoriasis and the former two also for psoriatic arthritis (PsA). Ustekinumab and risankizumab have appeared ineffective in randomised controlled trials with patients with axial spondyloarthritis (axSpA), but post-hoc analyses of PsA trials have now suggested that they may improve back pain symptoms potentially induced by axial inflammation based on PsA. Here we argue that, based on the absence of efficacy in axSpA, this is unlikely and more probably due to generic, non-specific effects, which are not adequately covered by the tools developed for the assessment of inflammation in axSpA.