tbuckley/cabot-search huggingface dataset:
Axillary pain and swelling
Authors: Laila Bhattacharya, Stuart Enoch
Journal: BMJ (2006)

A 44 year old man with a body mass index of 41 kg/m2 presented to the surgical outpatient clinic with a three month history of swelling, erythema, and small tender lumps in his right axillary region (fig 1). His general practitioner had prescribed oral antibiotics (three courses) and although the symptoms subsided temporarily, the condition soon recurred. He had had this problem on and off for the past 20 years (recurrent abscesses, pain, discharge, and occasional bleeding) and had had three surgical interventions (incision and drainage procedures), but with limited success. The patient had similar problems in the left axilla (fig 2) and both groins. He was a former smoker and his medical history was unremarkable apart from acne, varicose veins, and depression.

1.  What is this condition?

2.  Briefly describe its aetiology and pathophysiology.

3.  What are the differential diagnoses?

4.  What are the management options?

1.  Hidradenitis suppurativa.

2.  It is caused by recurrent infections of the apocrine sweat glands. Although the exact cause of this condition is unclear, it is widely believed that occlusion of the apocrine or follicular …
Abstract 9094: Intensive Lifestyle Medicine for Primary & Secondary Prevention for Cardiovascular Risk Reduction in Patients With Diabetes
Authors: S. Hammad Jafri, Tasnim F Imran, Andrew M Freeman, Dean Ornish, Wen-chih Wu
Journal: Circulation (2021)

Introduction: Cardiovascular disease (CVD) carries significant morbidity and mortality, especially for patients with diabetes. Intensive Cardiac rehabilitation (ICR) has proven benefits for patient...
Oxygen generating scaffolds regenerate critical size bone defects
Authors: Sanika Suvarnapathaki, Xinchen Wu, Tengfei Zhang, Michelle A. Nguyen, Anastasia A. Goulopoulos, Bin Wu, Gulden Camci-Unal
Journal: Bioactive Materials (2021)

Recent innovations in bone tissue engineering have introduced biomaterials that generate oxygen to substitute vasculature. This strategy provides the immediate oxygen required for tissue viability and graft maturation. Here we demonstrate a novel oxygen-generating tissue scaffold with predictable oxygen release kinetics and modular material properties. These hydrogel scaffolds were reinforced with microparticles comprised of emulsified calcium peroxide (CaO
309 Visualizing the immunotherapy-induced spatial reorganization of the tumor-immune microenvironment by CODEX multiplex imaging
Authors: Ruan Medrano, Fei Han, Bassem Ben Cheikh, Patrick Leinert, Wm Pat Leinert, Oliver Braubach, Robert Schreiber
Journal: Journal for ImmunoTherapy of Cancer (2021)

Background Tumors contain spatially organized microenvironments in which the location and composition of the cellular components ultimately determine tumor fate. We previously characterized CD45+ cells infiltrating T3 sarcomas using complementary forms of high-dimensional profiling (scRNAseq and CyTOF) and identified key immune cell populations that became associated either with growing tumors in mice treated with control antibody (cmAb) or rejecting tumors in mice treated with immune-checkpoint therapy (ICT) i.e., anti-PD-1 and/or anti-CTLA-4. To better understand the effects of the intratumoral immune cell populations on one another and on the tumor itself, we used CODEX multiplex imaging to simultaneously characterize expression of 35 distinct immune cell markers on tumor tissue sections thereby maintaining the spatial relationships between effector cells and their cognate tumor cell targets Methods T3 tumor bearing syngeneic mice were treated with cmAb or a-PD-1/a-CTLA-4 on days 6,9 and 12, harvested on different days, fresh frozen, cut in 8µM sections, transferred to coverslips, and stained with a panel of commercially available and custom-made CODEX antibodies following optimized staining conditions using the manufacturer’s protocol. Whole tumor tissue raw TIFF images were subjected to an image processing pipeline developed by Akoya Biosciences, Inc, where dapi+ cells used for cell segmentation by the Startdist method. Unsupervised clustering using Scanpy toolkit based on normalized marker expression profiles identified and validated 12 unique cell clusters Results When compared to the cmAb group, a-PD-1/a-CTLA-4 tumors harvested on day 10 displayed a marked increase in percentage as well as density of CD4+ and CD8+ T cells, Ly6G neutrophils, MHC-II+cd11c+cd24+DCs and a decrease of CD140a+ tumor cells. Spatial analysis indicated statistically significant differences in the organization of these cell types upon treatment with a-PD-1/a-CTLA-4 compared to cmAb treatment. Specifically, immune cells were found at the border of the tumor in cmAb treated mice and heavily infiltrated tumors following ICT. Neighborhood identification analysis revealed changes in the composition of the main neighborhood clusters, of which the top three clusters present in cmAb treated tumors (macrophage, tumor, and other immune cells) were substituted by clusters of CD4+ and CD8+ T cells, neutrophils, and macrophages. Conclusions These results not only confirm the remodeling of both the lymphoid and myeloid compartments previously observed with scRNAseq and CyTOF but also suggest that changes in the spatial organization of immune cells are drivers of the tumor rejection process upon treatment with ICT.
Tipping Cancer Cells Over the Edge: The Context-Dependent Cost of High Ploidy
Authors: Noemi Andor, Philipp M. Altrock, Navami Jain, Ana P. Gomes
Journal: Cancer Research (2021)

Tetraploidy is an aneuploidy-permissive condition that can fuel tumorgenesis. The tip-over hypothesis of cytotoxic therapy sensitivity proposes that therapy is effective if it pushes a cell's aneuploidy above a viable tipping point. But elevated aneuploidy alone may not account for this tipping point. Tissue microenvironments that lack sufficient resources to support tetraploid cells can explain the fitness cost of aneuploidy. Raw materials needed to generate deoxynucleotides, the building blocks of DNA, are candidate rate-limiting factors for the evolution of high-ploidy cancer cells. Understanding the resource cost of high ploidy is key to uncover its therapeutic vulnerabilities across tissue sites with versatile energy supplies.
Characterization of Cytotoxic Macrophages in a Pre-Clinical Model of Epstein-Barr Virus (EBV)-Driven Lymphoproliferative Disease
Authors: John Patton, Emily Smith, Zahary Smith, Andrew Stiff, A. Douglas Kinghorn, Yiping Yang, Michael R Grever, David M. Lucas, Robert Baiocchi
Journal: Blood (2021)
Epor Stimulates Rapid Cycling and Larger Red Cells during Mouse and Human Erythropoiesis
Authors: Daniel Hidalgo, Jacob Bejder, Ramona Pop, Kyle Gellatly, Yung Hwang, S. Maxwell Scalf, Anna Eastman, Jane-Jane Chen, Lihua Julie Zhu, Jules Heuberger, Shangqin Guo, Mark J. Koury, Nikolai Baastrup Nordsborg, Merav Socolovsky
Journal: Blood (2021)
Unraveling the drug distribution in brain enabled by MALDI MS imaging with laser-assisted chemical transfer
Authors: Shuai Guo, Kening Li, Yanwen Chen, Bin Li
Journal: Acta Pharmaceutica Sinica B (2021)

Accurate localization of central nervous system (CNS) drug distribution in the brain is quite challenging to matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI), owing to the ionization competition/suppression of highly abundant endogenous biomolecules and MALDI matrix. Herein, we developed a highly efficient sample preparation technique, laser-assisted chemical transfer (LACT), to enhance the detection sensitivity of CNS drugs in brain tissues. A focused diode laser source transilluminated the tissue slide coated with α-cyano-4-hydroxycinnamic acid, an optimal matrix to highly absorb the laser radiation at 405 nm, and a very thin-layer chemical film mainly containing drug molecule was transferred to the acceptor glass slide. Subsequently, MALDI MSI was performed on the chemical film without additional sample treatment. One major advantage of LACT is to minimize ionization competition/suppression from the tissue itself by removing abundant endogenous lipid and protein components. The superior performance of LACT led to the successful visualization of regional distribution patterns of 16 CNS drugs in the mouse brain. Furthermore, the dynamic spatial changes of risperidone and its metabolite were visualized over a 24-h period. Also, the brain-to-plasma (B/P) ratio could be obtained according to MALDI MSI results, providing an alternative means to assess brain penetration in drug discovery.
Allogeneic Stem Cell Transplantation Conditioned with Myeloablative Regimens Containing Total Body Irradiation in Adolescent and Young Adult Patients with Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia Who Were Treated with Pediatric-Type Chemotherapy
Authors: Hiroaki Shimizu, Jun Kato, Shun-ichi Kimura, Takayoshi Tachibana, Kaoru Hatano, Kensuke Usuki, Jun Taguchi, Maki Hagihara, Nobuhiro Tsukada, Kaito Harada, Satoshi Takahashi, Satoru Takada, Emiko Sakaida, Shin Fujisawa, Masahiro Onoda, Nobuyuki Aotsuka, Hiroshi Handa, Yoshihiro Hatta, Reiko Nakaseko, Shingo Yano, Kazuteru Ohashi, Yoshinobu Kanda
Journal: Blood (2021)
Morphology of Coronary Artery Disease in a Patient with, Psoriasis Presenting with an Acute Coronary Syndrome
Authors: Ranjit Sharma
Journal: Clinical Cardiology and Cardiovascular Interventions (2021)

Background: This study was designed to evaluate the patterns of coronary artery disease in patients with Psoriasis presenting with acute coronary syndrome (ACS). Methods: This was a prospective, observational study, conducted on 28 patients with Psoriasis, presenting with acute coronary syndrome undergoing coronary angiogram from September 2017 to March 2021. All patients had undergone coronary angiogram; severity and morphology of coronary lesion were analyzed. Echocardiography was used to analyze LV wall motion and LV function. Results: The study showed that of 28 patients with Psoriasis who presented with ACS, 45.8% of patients were presented with NSTEMI, 39.2% % STEMI, and Unstable angina 15%. The average time of presentation after the onset of the symptom was 14.8 hours. 66 % of patients were a smoker. Coronary involvement 50% had TVD, 40% DVD, and 10% had SVD. In 77.6% culprit vessel was LAD, 10.4% LCX, and 12% RCA. In 75% of patient's coronary lesion was located in the proximal LAD. Chronic total occlusion was found in almost 26% of patients. Extensive LV wall motion abnormality with severe LV systolic dysfunction was noted in Psoriasis patients at the time of presentation (mean LVEF=28%). Conclusions: Psoriasis patients presenting with ACS, associated with increased severity of coronary lesions, multivessel involvement, and depressed LV systolic function.
A proactive approach to tackling sexism in medical school
Authors: Adam Danquah, Gabrielle Finn, Margaret Kingston, Oyebanji Adewumi, Graham Lord
Journal: BMJ (2021)

We were appalled to read about Webb and colleagues’ experiences of sexism as medical students, and we commend them for their bravery in speaking out.1

They are reporting on a culture that is in plain sight but so normalised that it is almost invisible—not to those at the sharp end of sexism, but to the men and women who turn a blind eye or dismiss it as …
ポックリ病(有意な冠動脈縮窄をもたない突然死)患者からのレムナントリポ蛋白質は,Rhoキナーゼのアップレギュレーションを介して冠動脈血管れん縮活動を強める
Authors: Shimokawa H, Oi K, Hiroki J, Uwatoku T, Abe K, Matsumoto Y, Takeichi S, Takeshita A
Journal: Circulation (2003)
Use of Cryopreserved Allogeneic PBSC Results in Delayed Engraftment and Increased Incidence of Poor Graft Function
Authors: Samar Kulkarni, John Murray, James Clarke, Mike Dennis, Amit Patel, Anna Castleton, James Cavet, Angela Leather, Lyndsey Ashton, Diane Sweeney, Joanna Tomlins, Adrian Bloor, Rita Angelica, Mark Williams
Journal: Blood (2021)
A Prospective Randomized Multicenter Trial Using Either Deferiprone or Deferasirox after an Early Start of Deferiprone or Placebo in Young Children Newly Diagnosed with Transfusion-Dependent Beta-Thalassemia
Authors: Mohsen Saleh Elalfy, Amira Adly, Fatma Soliman Elsayed Ebeid, Amal El-Beshlawy, Neveen Salama, Mona Hamdy
Journal: Blood (2021)
Identifying Long Noncoding RNA Dependencies Using CRISPR <i>Interference</i> (CRISPRi)-Based Platform in Multiple Myeloma
Authors: Eugenio Morelli, Anil Aktas-Samur, Mehmet K. Samur, Annamaria Gulla, Leon Wert-Lamas, Caroline Ribeiro, Jonathan E Henninger, Woojun D Park, Nicola Amodio, Doriana Gramegna, Megan Johnstone, Pierfrancesco Tassone, Yu-Tzu Tai, Carl D. Novina, Richard A. Young, Massimo Loda, Masood A. Shammas, Sergei Gryaznov, Mariateresa Fulciniti, Kenneth C. Anderson, Nikhil C. Munshi
Journal: Blood (2021)
A Multi-Institutional Retrospective Analysis of T-Cell Lymphomas with Central Nervous System Relapse
Authors: Rahul S. Bhansali, Nivetha Ganesan, Robert N. Stuver, Steven M. Horwitz, Kitsada Wudhikarn, Steven R. Hwang, Nora Bennani, Julio C. Chavez, Lubomir Sokol, Hayder Saeed, Priyanka Pullarkat, Neha Mehta-Shah, Rishab Prakash, Swami P. Iyer, Adam J. Olszewski, Caroline Goldin, Brad M. Haverkos, Pamela Allen, Elise A Chong, James N Gerson, Daniel J Landsburg, Sunita Nasta, Stephen J. Schuster, Jakub Svoboda, Stefan K. Barta
Journal: Blood (2021)
Ibrutinib With Rituximab in First-Line Treatment of Older Patients With Mantle Cell Lymphoma
Authors: Preetesh Jain, Shuangtao Zhao, Hun Ju Lee, Holly A. Hill, Chi Young Ok, Rashmi Kanagal-Shamanna, Fredrick B. Hagemeister, Nathan Fowler, Luis Fayad, Yixin Yao, Yang Liu, Omar B. Moghrabi, Lucy Navsaria, Lei Feng, Graciela M. Nogueras Gonzalez, Guofan Xu, Selvi Thirumurthi, David Santos, Cezar Iliescu, Guilin Tang, L. Jeffrey Medeiros, Francisco Vega, Michelle Avellaneda, Maria Badillo, Christopher R. Flowers, Linghua Wang, Michael L. Wang
Journal: Journal of Clinical Oncology (2021)

Most patients with mantle cell lymphoma (MCL) are older. In this study, we investigated the efficacy and safety of a chemotherapy-free combination with ibrutinib and rituximab (IR) in previously untreated older patients with MCL (age ≥ 65 years).We enrolled 50 patients with MCL in this single-institution, single-arm, phase II clinical trial (NCT01880567). Patients with Ki-67% ≥ 50% and blastoid morphology were excluded. Ibrutinib was administered with rituximab up to 2 years with continuation of ibrutinib alone. The primary objective was to assess the overall response rate and safety of IR. In evaluable samples, whole-exome sequencing and bulk RNA sequencing from baseline tissue samples were performed.The median age was 71 years (interquartile range 69-76 years). Sixteen percent of patients had high-risk simplified MCL international prognostic index. The Ki-67% was low (< 30%) in 38 (76%) and moderately high (≥ 30%-50%) in 12 (24%) patients. The best overall response rate was 96% (71% complete response). After a median follow-up of 45 months (interquartile range 24-56 months), 28 (56%) patients came off study for various reasons (including four progression, 21 toxicities, and three miscellaneous reasons). The median progression-free survival and overall survival were not reached, and 3-year survival was 87% and 94%, respectively. None of the patients died on study therapy. Notably, 11 (22%) patients had grade 3 atrial fibrillation. Grade 3-4 myelosuppression was seen in < 5% of patients. Differential overexpression of CCND1, BIRC3, BANK1, SETBP1, AXIN2, and IL2RA was noted in partial responders compared with patients with complete response.IR combination is effective in older patients with MCL. Baseline evaluation for cardiovascular risks is highly recommended. Randomized trial is needed for definitive conclusions.
Outcomes with Mismatched Unrelated Donor Allogeneic Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis
Authors: Muhammad Umair Mushtaq, Moazzam Shahzad, Muhammad Usman Zafar, Muhammad Arslan, Ezza Tariq, Naira Fatima, Syeda Sadia Bokhari, Javeria Shahani, Iqra Anwar, Sibgha Gull Chaudhary, Anurag K. Singh, Sunil Abhyankar, Natalie S. Callander, Peiman Hematti, Joseph P. McGuirk
Journal: Blood (2021)
APOBEC3A drives deaminase domain-independent chromosomal instability to promote pancreatic cancer metastasis
Authors: Sonja M. Wörmann, Amy Zhang, Fredrik I. Thege, Robert W. Cowan, Dhwani N. Rupani, Runsheng Wang, Sara L. Manning, Chris Gates, Weisheng Wu, Rena Levin-Klein, Kimal I. Rajapakshe, Meifang Yu, Asha S. Multani, Ya’an Kang, Cullen M. Taniguchi, Katharina Schlacher, Melena D. Bellin, Matthew H. G. Katz, Michael P. Kim, Jason B. Fleming, Steven Gallinger, Ravikanth Maddipati, Reuben S. Harris, Faiyaz Notta, Susan R. Ross, Anirban Maitra, Andrew D. Rhim
Journal: Nature Cancer (2021)
Romiplostim, Low-Dose Rituximab and High-Dose Dexamethasone Combination in Newly Diagnosed Immune Thrombocytopenia: Another "Total Therapy" Pilot Study
Authors: Perla R. R. Colunga-Pedraza, Mónica Bustillos Muñoz, Fernando De La Garza, Andres Gomez-De Leon, Edgar Ulises Coronado-Alejandro, Eliezer Tomas Gomez Gomez, Ana Varela-Constantino, Gerardo A De la rosa-Flores, Olga Graciela Cantu Rodriguez, Cesar Homero Gutierrez-Aguirre, Luz del Carmen Tarín Arzaga, David Gomez-Almaguer
Journal: Blood (2021)
Limited Access to Transcranial Doppler Screening and Stroke Prevention for Children with Sickle Cell Disease in Europe: Results of a Multinational Eurobloodnet Survey
Authors: Daniela Cuzzubbo, Victoria Gutierrez-Valle, Maddalena Casale, Vincenzo Voi, Corrina McMahon, Maria Del Mar Mañú Pereira, Mariane de Montalembert, Baba PD Inusa, Raffaella Colombatti
Journal: Blood (2021)
Racial, Ethnic, and Socioeconomic Factors Result in Disparities in Outcome Among Children with Acute Lymphoblastic Leukemia Not Fully Attenuated By Disease Prognosticators: A Children's Oncology Group (COG) Study
Authors: Sumit Gupta, David T. Teachey, Meenakshi Devidas, Yunfeng Dai, Richard Aplenc, Lena Winestone, Kira O Bona, Karen R Rabin, Patrick A Zweidler-McKay, Kelly W Maloney, Leonard A. Mattano, Eric C Larsen, Anne L Angiolillo, Reuven J Schore, Michael J. Burke, Wanda L Salzer, Stuart S. Winter, Kimberly P. Dunsmore, Naomi J Winick, William L. Carroll, Stephen P Hunger, Mignon L. Loh
Journal: Blood (2021)
Abstract 9177: Prognostic Value of Chronic Kidney Disease and Cardiac Sympathetic Dysfunction Assessed by 123I-metaiodobenzylguanidine Scintigraphy for Lethal Arrhythmic Events in Chronic Heart Failure
Authors: Kazuaki Amami, Shinya Yamada, Takashi Kaneshiro, Akiomi Yoshihisa, Naoko Hijioka, Minoru Nodera, Yasuchika Takeishi
Journal: Circulation (2021)

Introduction: Clinical implication of chronic kidney disease (CKD) and cardiac sympathetic nerve activity (CSNA) for lethal arrhythmic events has not been fully elucidated in patients with chronic ...
HBV covalently closed circular DNA minichromosomes in distinct epigenetic transcriptional states differ in their vulnerability to damage
Authors: Yang Wang, Yumeng Li, Wenjing Zai, Kongying Hu, Yuanfei Zhu, Qiang Deng, Min Wu, Yaming Li, Jieliang Chen, Zhenghong Yuan
Journal: Hepatology (2021)

HBV covalently closed circular DNA (cccDNA) is a major obstacle for a cure of chronic hepatitis B. Accumulating evidence suggests that epigenetic modifications regulate the transcriptional activity of cccDNA minichromosomes. However, it remains unclear how the epigenetic state of cccDNA affects its stability.
Identification and Development of PHE885: A Novel and Highly Potent Fully Human Anti-BCMA CAR-T Manufactured with a Novel T-Charge TM Platform for the Treatment of Multiple Myeloma
Authors: Dexiu Bu, Paul Bennett, Nathaniel Barton, Laura Bradshaw, Maria Pinon-Ortiz, Xiangen Li, Poonam Vaidya, Xu Zhu, Keith Mansfield, Brian Granda, Carla P Guimaraes, Louise M Treanor, Jennifer L Brogdon
Journal: Blood (2021)
Allogeneic NKT Cells Expressing a CD19-Specific CAR in Patients with Relapsed or Refractory B-Cell Malignancies: An Interim Analysis
Authors: Carlos A. Ramos, Amy N. Courtney, Simon N. Robinson, Olga Dakhova, Premal D. Lulla, Rammurti Kamble, George Carrum, Tao Wang, Chunchao Zhang, Erica Di Pierro, Leonid S. Metelitsa
Journal: Blood (2021)
Immunogenicity of Sars-Cov-2 mRNA 1273 Vaccine in Patients with Lymphoid Malignancies
Authors: Ning Dong, Akriti G Jain, Elaine S Tan, Somedeb Ball, Junmin Whiting, Sameh Gaballa, Leidy Isenalumhe, Celeste Bello, Hayder Saeed, Bijal D. Shah, Frederick L. Locke, Julio C. Chavez, Jeffrey E. Lancet, Lubomir Sokol, Javier Pinilla Ibarz, Anna Giuliano
Journal: Blood (2021)
Presence of Extrachromosomal DNA (ecDNA) Impacts Both Progression Free and Overall Survival and Is an Independent Poor Prognostic Marker in Multiple Myeloma
Authors: Parth Shah, Anil Aktas-Samur, Mariateresa Fulciniti, Raphael Szalat, Masood A. Shammas, Paul G. Richardson, Florence Magrangeas, Stephane Minvielle, Aurore Perrot, Jill Corre, Philippe Moreau, Anjan Thakurta, Kenneth C. Anderson, Herve Avet-Loiseau, Nikhil C. Munshi, Mehmet K. Samur
Journal: Blood (2021)
Categorization of Differing Types of Total Pancreatectomy
Authors: Martin Loos, Mohammed Al-Saeedi, Ulf Hinz, Arianeb Mehrabi, Martin Schneider, Christoph Berchtold, Beat P. Müller-Stich, Thomas Schmidt, Yakup Kulu, Katrin Hoffmann, Oliver Strobel, Thilo Hackert, Markus W. Büchler
Journal: JAMA Surgery (2021)

Comparability of morbidity and mortality rates after total pancreatectomy (TP) reported by different surgical centers is limited. Procedure-specific differences, such as the extent of resection, including additional vascular or multivisceral resections, are rarely acknowledged when postoperative outcomes are reported.To evaluate postoperative outcomes after TP and categorize different types of TP based on the extent, complexity, and technical aspects of each procedure.This single-center study included a retrospective cohort of 1451 patients who had undergone TP between October 1, 2001, and December 31, 2020. Each patient was assigned to 1 of the following 4 categories that reflect increasing levels of procedure-related difficulty: standard TP (type 1), TP with venous resection (type 2), TP with multivisceral resection (type 3), and TP with arterial resection (type 4). Postoperative outcomes among the groups were compared.Categorization of different types of TP based on the procedure-related difficulty and differing postoperative outcomes.Of the 1451 patients who had undergone TP and were included in the analysis, 840 were men (57.9%); median age was 64.9 (IQR, 56.7-71.7) years. A total of 676 patients (46.6%) were assigned to type 1, 296 patients (20.4%) to type 2, 314 patients (21.6%) to type 3, and 165 patients (11.4%) to type 4 TP. A gradual increase in surgical morbidity was noted by TP type (type 1: 255 [37.7%], type 2: 137 [46.3%], type 3: 178 [56.7%], and type 4: 98 [59.4%]; P < .001), as was noted for median length of hospital stay (type 1: 14 [IQR, 10-19] days, type 2: 16 [IQR, 12-23] days, type 3: 17 [IQR, 13-29] days, and type 4: 18 [IQR, 13-30] days; P < .001), and 90-day mortality (type 1: 23 [3.4%], type 2: 17 [5.7%], type 3: 29 [9.2%], and type 4: 20 [12.1%]; P < .001). In the multivariable analysis, type 3 (TP with multivisceral resection) and type 4 (TP with arterial resection) were independently associated with an increased 90-day mortality rate.The findings of this study suggest there are significant differences in postoperative outcomes when the extent, complexity, and technical aspects of the procedure are considered. Classifying TP into 4 different categories may allow for better postoperative risk stratification as well as more accurate comparisons in future studies.
Epidemiology and Risk Factors for the Development of Infectious Complications in Patients with Multiple Myeloma: A Multicenter Prospective Cohort Study in Latin America
Authors: Eloísa Riva, Virginia Bove, Jule Vasquez, Camila Peña, Cristian Seehaus, Cesar Samanez-Figari, Justina Bustos, Marcos Hernandez, Julio Fernandez, Rosa Oliday Rios, Yusaima Rodriguez, Irving Figueredo, Dorotea Fantl
Journal: Blood (2021)