tbuckley/cabot-search huggingface dataset:
Epidemiology of Heart Failure
Authors: Véronique L. Roger
Journal: Circulation Research (2021)

Designated as an emerging epidemic in 1997, heart failure (HF) remains a major clinical and public health problem. This review focuses on the most recent studies identified by searching the Medline database for publications with the subject headings HF, epidemiology, prevalence, incidence, trends between 2010 and present. Publications relevant to epidemiology and population sciences were retained for discussion in this review after reviewing abstracts for relevance to these topics. Studies of the epidemiology of HF over the past decade have improved our understanding of the HF syndrome and of its complexity. Data suggest that the incidence of HF is mostly flat or declining but that the burden of mortality and hospitalization remains mostly unabated despite significant ongoing efforts to treat and manage HF. The evolution of the case mix of HF continues to be characterized by an increasing proportion of cases with preserved ejection fraction, for which established effective treatments are mostly lacking. Major disparities in the occurrence, presentation, and outcome of HF persist particularly among younger Black men and women. These disturbing trends reflect the complexity of the HF syndrome, the insufficient mechanistic understanding of its various manifestations and presentations and the challenges of its management as a chronic disease, often integrated within a context of aging and multimorbidity. Emerging risk factors including omics science offer the promise of discovering new mechanistic pathways that lead to HF. Holistic management approaches must recognize HF as a syndemic and foster the implementation of multidisciplinary approaches to address major contributors to the persisting burden of HF including multimorbidity, aging, and social determinants of health.
Late effects of low-energy gamma emitting stents in a rabbit iliac injury model Bradley H. Strauss, Chris Li, Heather A. Whittingham, Fermin O. Tio, Michael J. B. Kutryk, John D. Sparkes, Todd Turnlund, William L. Sweet. St. Michael's Hospital, Toronto, ON, Canada, University of Texas Health Science Center, San Antonio, TX
Journal: Journal of the American College of Cardiology (2001)
Leads from the MMWR. Rubella outbreaks in prisons--New York City, West Virginia, California
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Quantitative ultraharmonic myocardial contrast echocardiography: Human subjects with normal angiography Anita M. Kelsey, Francis J. Kiernan, Daniel B. Fram, Emily Schopick, Lisa V. Carl, Bridget Smith, Alwyn D'Sa, Marc Filerman, Linda D. Gillam. Hartford Hospital, Hartford, CT, Agilent Technologies, Andover, MA
Journal: Journal of the American College of Cardiology (2001)
PLGA's Plight and the Role of Stealth Surface Modification Strategies in Its Use for Intravenous Particulate Drug Delivery
Authors: Violet V. Sheffey, Emily B. Siew, Eden E. L. Tanner, Omolola Eniola‐Adefeso
Journal: Advanced Healthcare Materials (2022)

Numerous human disorders can benefit from targeted, intravenous (IV) drug delivery. Polymeric nanoparticles have been designed to undergo systemic circulation and deliver their therapeutic cargo to target sites in a controlled manner. Poly(lactic-co-glycolic) acid (PLGA) is a particularly promising biomaterial for designing intravenous drug carriers due to its biocompatibility, biodegradability, and history of clinical success across other routes of administration. Despite these merits, PLGA remains markedly absent in clinically approved IV drug delivery formulations. A prominent factor in PLGA particles' inability to succeed intravenously may lie in the hydrophobic character of the polyester, leading to the adsorption of serum proteins (i.e., opsonization) and a cascade of events that end in their premature clearance from the bloodstream. PEGylation, or surface-attached polyethylene glycol chains, is a common strategy for shielding particles from opsonization. Polyethylene glycol (PEG) continues to be regarded as the ultimate "stealth" solution despite the lack of clinical progress of PEGylated PLGA carriers. This review reflects on some of the reasons for the clinical failure of PLGA, particularly the drawbacks of PEGylation, and highlights alternative surface coatings on PLGA particles. Ultimately, a new approach will be needed to harness the potential of PLGA nanoparticles and allow their widespread clinical adoption.
Positive Selection and Enhancer Evolution Shaped Lifespan and Body Mass in Great Apes
Authors: Daniela Tejada-Martinez, Roberto A Avelar, Inês Lopes, Bruce Zhang, Guy Novoa, João Pedro de Magalhães, Marco Trizzino
Journal: Molecular Biology and Evolution (2021)

Within primates, the great apes are outliers both in terms of body size and lifespan, since they include the largest and longest-lived species in the order. Yet, the molecular bases underlying such features are poorly understood. Here, we leveraged an integrated approach to investigate multiple sources of molecular variation across primates, focusing on over 10,000 genes, including approximately 1,500 previously associated with lifespan, and additional approximately 9,000 for which an association with longevity has never been suggested. We analyzed dN/dS rates, positive selection, gene expression (RNA-seq), and gene regulation (ChIP-seq). By analyzing the correlation between dN/dS, maximum lifespan, and body mass, we identified 276 genes whose rate of evolution positively correlates with maximum lifespan in primates. Further, we identified five genes, important for tumor suppression, adaptive immunity, metastasis, and inflammation, under positive selection exclusively in the great ape lineage. RNA-seq data, generated from the liver of six species representing all the primate lineages, revealed that 8% of approximately 1,500 genes previously associated with longevity are differentially expressed in apes relative to other primates. Importantly, by integrating RNA-seq with ChIP-seq for H3K27ac (which marks active enhancers), we show that the differentially expressed longevity genes are significantly more likely than expected to be located near a novel "ape-specific" enhancer. Moreover, these particular ape-specific enhancers are enriched for young transposable elements, and specifically SINE-Vntr-Alus. In summary, we demonstrate that multiple evolutionary forces have contributed to the evolution of lifespan and body size in primates.
Prolonged oral antimicrobial administration prevents doxorubicin-induced loss of active intestinal stem cells
Authors: Breanna J Sheahan, Casey M Theriot, Jocsa E. Cortes, Christopher M Dekaney
Journal: Gut Microbes (2022)

Acute intestinal mucositis is a common off-target effect of chemotherapy, leading to co-morbidities such as vomiting, diarrhea, sepsis, and death. We previously demonstrated that the presence of enteric bacteria modulates the extent of jejunal epithelial damage induced by doxorubicin (DXR) in mice. Despite conventional thinking of the crypt as a sterile environment, recent evidence suggests that bacterial signaling influences aISC function. In this study, we labeled aISCs using transgenic Lgr5-driven fluorescence or with immunostaining for OLFM4. We examined the effect of DXR in both germ free (GF) mice and mice depleted of microbiota using an established antimicrobial treatment protocol (AMBx). We found differences in DXR-induced loss of aISCs between GF mice and mice treated with AMBx. aISCs were decreased after DXR in GF mice, whereas AMBx mice retained aISC expression after DXR. Neither group of mice exhibited an inflammatory response to DXR, suggesting the difference in aISC retention was not due to differences in local tissue inflammation. Therefore, we suspected that there was a protective microbial signal present in the AMBx mice that was not present in the GF mice. 16S rRNA sequencing of jejunal luminal contents demonstrated that AMBx altered the fecal and jejunal microbiota. In the jejunal contents, AMBx mice had increased abundance of Ureaplasma and Burkholderia. These results suggest pro-survival signaling from microbiota in AMBx-treated mice to the aISCs, and that this signaling maintains aISCs in the face of chemotherapeutic injury. Manipulation of the enteric microbiota presents a therapeutic target for reducing the severity of chemotherapy-associated mucositis.
Early recurrence of atrial fibrillation following ambulatory shock conversion by an implanted atrial arrhythmia management device: Incidence and predictors David Schwartzman, Shaileshkumar Musley, Eduardo Warman, Charles D. Swerdlow, Rahul Mehra. Atrial Arrhythmia Center, University of Pittsburgh, Pittsburgh, PA, Medtronic. Inc., Minneapolis, MN
Journal: Journal of the American College of Cardiology (2001)
Error in Author’s Name
Authors: John Betjemann, J Hemphill, Urmimala Sarkar, Zuckerberg San
Journal: JAMA Neurology (2020)

Aaron F. Struck, MD; Mohammad Tabaeizadeh, MD; Sarah E. Schmitt, MD; Andres Rodriguez Ruiz, MD; Christa B. Swisher, MD; Thanujaa Subramaniam, MD; Christian Hernandez, MD; Safa Kaleem, BS; Hiba A. Haider, MD; Abbas Fodé Cissé, MD; Monica B. Dhakar, MD; Lawrence J. Hirsch, MD; Eric S. Rosenthal, MD; Sahar F. Zafar, MD; Nicholas Gaspard, MD, PhD; M. Brandon Westover, MD, PhD
Leads from the MMWR. Update: universal precautions for prevention of transmission of human immunodeficiency virus, hepatitis B virus, and other bloodborne pathogens in health-care settings
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Excess Deaths From COVID-19 and Other Causes, March-July 2020
Authors: Steven H. Woolf, Derek A. Chapman, Roy T. Sabo, Daniel M. Weinberger, Latoya Hill, DaShaunda D. H. Taylor
Journal: JAMA (2020)

This study updates a previous report of the estimated number of excess deaths in the US during the coronavirus disease 2019 (COVID-19) pandemic through August 1, 2020, and describes causes of those deaths and temporal relationships with state lifting of coronavirus restrictions.
Classic Pages
Journal: Circulation Research (1968)

11 risultato di questo espei'imento si vede sul diagramma che riproduco : In esso si vede che per ottenere ancora il polso alia radiale -nelle condizioni cadaveriche in cui operavo -fui obbligato ad adoperare una pulsazioiie assai alta all'ascellare; si vede, nello stesso tempo, tenendo conto degli zeri dei rispettivi manometri, che la pressione sfigmomanometrica e un po' superiors alia pressione.staticasegnata dalla linea orizzontale; se non raggiunge l'acrae delle pulsazioni del manometro superiore, conviene anche ricordare che alia produzione di que.steultime doveva intervenire non indifferente il fenomeno della proiezione in misura molto niaggiore nel tubo uniformemente calibrate del manometro che nelle arterie delParto.Adunque, per quanto e possibile, con le disposizioni artificial!, mi pare resti confermato che il mio strumento segna, nel momento in cui cessa il polso, la pressione massima, il carico totale, e, sovratutto, la segnanelle condizioni sperimentali csposte -con esattezza.Si pud fare la doinanda se avviene lo stesso nell'uoino.L'esperienza diretta non e materialinente e moralmente concessa.Ho tentato di sostituirla coH'esperienza sull'aniinale che tracopio dal protocollo.I. -23 luglio 1890.-Cane piccolo.Ore 9 -Gr.0,005 di cloridrato di morfina per via ipodermica.D 9,15' -Cloroformizzazione.Si applica un chimiografo a mercurio nell'arteria crurale sinistra, a pressione terminate; sulla coscia destra viene applicato lo sfigmomanometro.B 9,32' -Manometro del -chimiografo mm.86-88.Sfigmomanometro 87.Per un incidente, dovuto al movimento dell'animale, I'esperienza viene interrotta.II.-26 luglio 189G.-Coniglio grosso.Ore 15,15' -Si applica nell'arteria crurale sinistra un manometroterminate, snlla coscia destra lo sfigmomanometro.9 15,38' -Manometro 81 mm.Hg.Sfigmomanometro 80 mm.Hg. • 15,40' -Si iniettano 3 /io di siringa di una soluzione di cloruiodi bario al 5 % n e l l a v e n a dell'orecchio.» 15,42'-Manometro 141-142.Sfigmomanometro 141.» 15,45'-»
Medicaid Cut
Authors: Mike Mitka
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P086: The Association between Psychological Distress and Diabetes Prevalence among Foreign-Born Blacks in the United States: An Examination of the 2010-2014 National Health Interview Survey
Authors: Nwakaego Ukonu, Ruth-Alma Turkson-Ocran, Yvonne Commodore-Mensah
Journal: Circulation (2017)

Background: Psychological distress, a leading cause of disability globally, is highly prevalent in people diagnosed with diabetes. Blacks in the U.S. are disproportionately affected by chronic conditions such as diabetes. Taken together, psychological distress and diabetes constitute an immense health burden and result in poor health outcomes, increased mortality and decreased quality of life. While the association between psychological distress and diabetes is documented among U.S.-born Blacks, this relationship remains poorly examined among the growing foreign-born Black population in the U.S. Hypothesis: We hypothesized that psychological distress (non-specific) would be associated with a higher prevalence of diabetes among a sample of foreign-born Blacks in the U.S. Methods: We analyzed data on adult foreign-born Blacks in the 2010-2014 National Health Interview Survey which is a national in-person survey of non-institutionalized persons in the U.S. The main independent variable was psychological distress which was defined as a score of ≥ 12 on the Kessler Psychological Distress Scale (K-6 Scale) . The main outcome variable was diabetes. Multivariable logistic regression was performed to examine the association between psychological distress and diabetes prevalence adjusting for known confounders. Results: A total of 2,974 foreign-born Blacks were included in this study. The mean age (±SE) was 43.9 (±15.3)and nearly half (53.3%) were female. Among the individuals who received the K-6 Scale, 13.3% indicated experiencing symptoms of depression within the last 30 days and 10% had diabetes. After adjusting for age, sex, body mass index, poverty status, and marital status, we observed that foreign-born Blacks with higher levels of psychological distress had 2.30 (95% CI: 1.69-3.12) higher odds of being diabetic in comparison to those without psychological distress. Conclusion: In a sample of contemporary foreign-born Blacks in the U.S., we observed that psychological distress was associated with prevalence of diabetes, such that individuals with elevated levels of psychological distress were twice as likely to be diabetic. Additional barriers may be associated with managing diabetes when a co-morbid mental health condition such as depression is present. Thus, culturally-tailored behavioral health interventions should be developed and utilized among foreign-born Black sub-populations to help promote adherence to complex behavioral and medical regimens associated with diabetes management.
Predicting pandemics
Authors: None The Lancet
Journal: The Lancet (2016)

"The world is ill prepared to respond to a severe influenza pandemic or to any similarly global, sustained and threatening public-health emergency", concluded an investigation into WHO's response to the 2009 H1N1 pandemic. In 2014, this unpreparedness was again exposed when the Ebola virus struck west Africa and claimed more than 11 000 lives. The continuing Zika virus epidemic highlights that lessons still need to be learned.
CAROTID REVASCULARIZATION IMMEDIATELY PRIOR TO URGENT CARDIAC SURGERY: CLINICAL OUTCOMES ASSOCIATED WITH THE CHOICE OF CAROTID ARTERY STENTING (CAS) OR ENDARTERECTOMY (CEA) FROM THE NCDR-CARE REGISTRY
Authors: Creighton W. Don, John House, Kevin Kennedy, Christopher White, Al Woodward, Mary Weideman, Kenneth Rosenfield
Journal: Journal of the American College of Cardiology (2010)
TCT-859 Transcatheter Aortic Valve Implantation with Edwards SAPIEN™ versus Medtronic CoreValve Revalving System® Devices: a Multi-Center Collaborative Study The PRAGMATIC Initiative – Pooled RotterdAm-Milano-Toulouse In Collaboration
Authors: Alaide Chieffo, Gill Buchanan, Nicolas Van Mieghem, Azeem Latib, Didier Tchetche, Nicolas Dumonteil, Robert M.A. Van der Boon, Olivier Vahdat, Bertrand Marcheix, Patrick Serruys, Didier Carrié, Jean Fajadet, Peter De Jaegere, Ottavio Alfieri, Antonio Colombo
Journal: Journal of the American College of Cardiology (2012)
Allergy: Principles and Practice
Authors: N. R. Rose
Journal: JAMA (1989)

When von Pirquet coined the term "allergy" at the beginning of this century, he had in mind a general designation of "altered reactivities" to external stimuli. Some responses may be beneficial to the host, ie, prophylactic, Whereas other responses may be harmful or anaphylactic. By common usage, "allergy" has come to mean a group of human diseases based on exaggerated immune responses to inhaled, ingested, or injected foreign substances. The most striking of these overexuberant responses are attributable to elevated production of antibodies of the IgE class, although other immunoglobulin classes are known to produce signs of allergy. Sometimes other mechanisms are involved, including the production of immune complexes and of antigenspecific effector T cells. Allergy as a medical specialty, then, has grown up around the diagnosis and treatment of this group of disorders. The fact that allergy is a medical specialty based on etiology rather than on anatomic location
Anlotinib combined with mXELIRI as second-line treatment in advanced colorectal cancer pretreated with bevacizumab plus standard chemotherapy: A single-arm, phase IB/II study.
Authors: Xin Qu, Xian Chen, Yong Li, Li-rong Liu, Yan-chun Qu, Fang-fang Hou, Wen-zhu Li, Yi-hong Liu, Yan-juan Zhu, Haibo Zhang
Journal: Journal of Clinical Oncology (2022)

TPS220 Background: For advanced colorectal cancer (CRC), fluoropyrimidine-based chemotherapy (5-FU or capecitabine combined with oxaliplatin) with VEGF inhibitors (bevacizumab) is standard first-line treatment. However, once this treatment had been used, the second line treatment is limited. Although continuation of bevacizumab after first progression can improve PFS and OS, the benefit of bevacizumab may be reduced compared with who never pre-treated with bevacizumab (the ML18147 study). Anlotinib is an oral small molecule tyrosine kinases inhibitor, targeting VEGF receptors 1/2/3, FGF receptors 1-4, PDGF receptors α/β and c-kit. mXELIRI is a chemotherapy regimen consisting of irinotecan and capecitabine. The trial is to investigate the efficacy and safety of anlotinib combined with mXELIRI as second-line treatment in advanced colorectal cancer pre-treated with bevacizumab plus standard chemotherapy. Methods: This is a multi-center, prospective, single-arm, 2-part, phase Ib/II study. Eligible pts are aged 18-75 years with histologically and radiographically confirmed mCRC who had progressed or intolerant with bevacizumab plus FOLFOX or CAPEOX regimen chemotherapy treatment. ECOG performance status 0 - 1, and adequate organ function. Treatment: anlotinib (8mg, 10mg or 12mg), po, qd, on days 1-14 every 3 weeks; irinotecan 180-200 mg/m 2 , iv, on day 1 every 3 weeks; capecitabine, 800 mg/m 2 , po, bid, on days 1-14 every 3 weeks. For the phase 1b segment, a standard 3+3 dose-escalation design is used to determine the maximum tolerated dose or recommended phase 2 dose (RP2D) of anlotinib. 3 patients are enrolled and treated per dose level (8mg,10mg,12mg). If no DLT, dose is escalated for the next cohort of 3 patients; If 1 DLT, 3 additional patients are treated at this level with dose escalation only if no additional DLTs；If ≥ 2 DLTs, prior dose level is defined as MTD. MTD decided when 6 patients are treated at a dose level with &lt; 2 DLTs. Primary endpoint is objective response rate (ORR) according to RECIST v1.1. Secondary endpoints are progression-free survival (PFS), overall survival (OS), disease control rate (DCR), duration of response (DOR) and quality of life (QoL). Based on a one-sided one sample log-rank test with 2.5% Type I error, 80% power to detect an improvement in ORR from 5.4% to 15%, there will be 94 patients consider 20% of patients fall off. Research Sponsor: Guangdong Provincial Hospital of Chinese Medicine Clinical trial information: NCT05035914.