tbuckley/cabot-search huggingface dataset:
Characteristics and Precipitating Circumstances of Suicide Among Children Aged 5 to 11 Years in the United States, 2013-2017
Authors: Donna A. Ruch, Kendra M. Heck, Arielle H. Sheftall, Cynthia A. Fontanella, Jack Stevens, Motao Zhu, Lisa M. Horowitz, John V. Campo, Jeffrey A. Bridge
Journal: JAMA Network Open (2021)

Suicide is the eighth leading cause of death among children aged 5 to 11 years, with rates increasing during the past decade. A better understanding of factors associated with childhood suicide can inform developmentally appropriate prevention strategies.To examine characteristics and precipitating circumstances of childhood suicide.This qualitative study examined restricted-use data from the National Violent Death Reporting System (NVDRS) regarding child suicide decedents aged 5 to 11 years in the US from 2013 to 2017. The NVDRS is a state-based surveillance system that collects data on suicide and violent deaths in 50 states, with restricted-use data available from 37 states. Details and context related to suicide deaths were identified through a content analysis of case narratives from coroner or medical examiner and law enforcement reports associated with each incident.Characteristics and precipitating circumstances associated with suicide cited in the coroner, medical examiner, and law enforcement case narratives.Suicide incidence and risk factors for suicide including mental health, prior suicidal behavior, trauma, and peer, school, or family-related problems.Analyses included 134 child decedents (101 [75.4%] males; 79 [59.0%] White individuals; 109 [81.3%] non-Hispanic individuals; mean [SD] age, 10.6 [0.8] years). Most suicides occurred in the child's home (95.5% [n = 128]), and more specifically in the child's bedroom. Suicide by hanging or suffocation (78.4% [n = 105]) was the most frequent method, followed by firearms (18.7% [n = 25]). Details on gun access were noted in 88.0% (n = 22) of suicides by firearm, and in every case, the child obtained a firearm stored unsafely in the home. Findings revealed childhood suicide was associated with numerous risk factors accumulated over time, and suggest a progression toward suicidal behavior, especially for youth with a history of psychopathology and suicidal behavior. An argument between the child and a family member and/or disciplinary action was often a precipitating circumstance of the suicide.This qualitative study found that childhood suicide was associated with multiple risk factors and commonly preceded by a negative precipitating event. Potential prevention strategies include improvements in suicide risk assessment, family relations, and lethal means restriction, particularly safe firearm storage. Future research examining the myriad aspects of childhood suicide, including racial/ethnic and sex differences, is needed.
Low oxygen levels decrease adaptive immune responses and ameliorate experimental asthma in mice
Authors: Mathias Hochgerner, Eva M. Sturm, Diana Schnoegl, Grazyna Kwapiszewska, Horst Olschewski, Leigh M. Marsh
Journal: Allergy (2021)

High-altitude therapy has been used as add-on treatment for allergic asthma with considerable success. However, the underlying mechanisms remain unclear. In order to investigate the possible therapeutic effects of high-altitude therapy on allergic asthma, we utilized a new in vivo mouse model.Mice were treated with house dust mite (HDM) extract over 4 weeks and co-exposed to 10% oxygen (Hyp) or room air for the final 2 weeks. Experimental asthma was assessed by airway hyper-responsiveness, mucus hypersecretion and inflammatory cell recruitment. Isolated immune cells from mouse and allergic patients were stimulated in vitro with HDM under Hyp and normoxia in different co-culture systems to analyse the adaptive immune response.Compared to HDM-treated mice in room air, HDM-treated Hyp-mice displayed ameliorated mucosal hypersecretion and airway hyper-responsiveness. The attenuated asthma phenotype was associated with strongly reduced activation of antigen-presenting cells (APCs), effector cell infiltration and cytokine secretion. In vitro, hypoxia almost completely suppressed the HDM-induced adaptive immune response in both mouse and human immune cells. While hypoxia did not affect effector T-cell responses per-se, it interfered with antigen-presenting cell (APC) differentiation and APC/effector cell crosstalk.Hypoxia-induced reduction in the Th2-response to HDM ameliorates allergic asthma in vivo. Hypoxia interferes with APC/T-cell crosstalk and confers an unresponsive phenotype to APCs.
A fluid-supported 3D hydrogel bioprinting method
Authors: Cyrus W. Beh, Dionis S. Yew, Ruth J. Chai, Sau Yin Chin, Yiqi Seow, Shawn S. Hoon
Journal: Biomaterials (2021)

Hydrogels are used in many biomedical applications, including regenerative medicine and surgical training phantoms. However, the ability to shape these materials into complex anatomical structures using additive manufacturing is limited in part by their low mechanical stiffness. We developed a hydrogel 3D printer, that projects patterns directly onto a thin layer of fluid-supported hydrogel precursor, which serves as a floating, liquid projection screen. This approach avoids inadvertent adhesion that affects typical resin-based 3D printers, and enables fast, continuous printing. As a consequence, we can print smooth objects free of layering artifacts, at rates of 200 mm/h along the Z-axis. We demonstrate the versatility of our approach by printing various complex structures, including free-standing channel networks with 500 μm-thick walls, using hydrogels with a wide range of stiffness from 7 kPa to more than 4 MPa. Lastly, because the printer features a free surface, we combined it with an extruder to perform multi-material printing. We use this strategy to create centimeter-scale, cell-laden hydrogels containing channels, that help address the key nutrient supply problem in bioprinting.
Resident cardiac macrophages mediate adaptive myocardial remodeling
Authors: Nicole R. Wong, Jay Mohan, Benjamin J. Kopecky, Shuchi Guo, Lixia Du, Jamison Leid, Guoshuai Feng, Inessa Lokshina, Oleksandr Dmytrenko, Hannah Luehmann, Geetika Bajpai, Laura Ewald, Lauren Bell, Nikhil Patel, Andrea Bredemeyer, Carla J. Weinheimer, Jessica M. Nigro, Attila Kovacs, Sachio Morimoto, Peter O. Bayguinov, Max.R. Fisher, W. Tom Stump, Michael Greenberg, James A.J. Fitzpatrick, Slava Epelman, Daniel Kreisel, Rajan Sah, Yongjian Liu, Hongzhen Hu, Kory J. Lavine
Journal: Immunity (2021)
P30-1 The influence of thiamine declines on neuropsychiatric symptoms in patients with hematological cancer
Authors: Yohei Iimura, Shohei Andoh, Toyotaka Kawamata, Aki Sato, Kazuaki Yokoyama, Yoichi Imai, Arinobu Tojo, Masanori Nojima, Munetoshi Sugiura, Seiichiro Kuroda
Journal: Annals of Oncology (2021)
Recommendations in the American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis Related to the Use of Biologic Agents in Patients With a History of Cancer Need Reconsideration: Comment on the Article by Singh et al
Authors: Hasan Yazici, Yesim Ozguler, Gulen Hatemi, Yusuf Yazici
Journal: Arthritis & Rheumatology (2016)
Abstract 15608: IL-1 Beta Signaling Characterization in Human Immune Cells by Mass Cytometry
Authors: Hema Kothari, Chantel McSkimming, Corey Williams, Mythili Vigneshwar, Eli Zunder, Coleen McNamara
Journal: Circulation (2019)

Introduction: Aberrant IL-1β production leads to immune-inflammatory activation in atherothrombosis. IL-1β inhibition has emerged as a novel therapy for reducing cardiovascular events. In vitro and...
Mapping each pre-existing condition’s association to short-term and long-term COVID-19 complications
Authors: A. J. Venkatakrishnan, Colin Pawlowski, David Zemmour, Travis Hughes, Akash Anand, Gabriela Berner, Nikhil Kayal, Arjun Puranik, Ian Conrad, Sairam Bade, Rakesh Barve, Purushottam Sinha, John C. O‘Horo, Andrew D. Badley, John Halamka, Venky Soundararajan
Journal: npj Digital Medicine (2021)

Abstract Understanding the relationships between pre-existing conditions and complications of COVID-19 infection is critical to identifying which patients will develop severe disease. Here, we leverage ~1.1 million clinical notes from 1803 hospitalized COVID-19 patients and deep neural network models to characterize associations between 21 pre-existing conditions and the development of 20 complications (e.g. respiratory, cardiovascular, renal, and hematologic) of COVID-19 infection throughout the course of infection (i.e. 0–30 days, 31–60 days, and 61–90 days). Pleural effusion was the most frequent complication of early COVID-19 infection (89/1803 patients, 4.9%) followed by cardiac arrhythmia (45/1803 patients, 2.5%). Notably, hypertension was the most significant risk factor associated with 10 different complications including acute respiratory distress syndrome, cardiac arrhythmia, and anemia. The onset of new complications after 30 days is rare and most commonly involves pleural effusion (31–60 days: 11 patients, 61–90 days: 9 patients). Lastly, comparing the rates of complications with a propensity-matched COVID-negative hospitalized population confirmed the importance of hypertension as a risk factor for early-onset complications. Overall, the associations between pre-COVID conditions and COVID-associated complications presented here may form the basis for the development of risk assessment scores to guide clinical care pathways.
VICTOR: Vinflunine in advanced metastatic transitional cell carcinoma of the urothelium (TCCU): a retrospective analysis of the use of vinflunine in multi-centre real life setting as second line chemotherapy through free of charge programme (FOCP) for patients in the UK and Ireland
Authors: S. Hussain, J. Ansari, R. Huddart, D. Power, J. Lyons, J. Wylie, M. Vilarino-Varela, N. Elander, R. McMenemin, L. Pickering, G. Faust, S. Chauhan, R. Jakson
Journal: Annals of Oncology (2016)
眼表面の膜関連ムチン:新しい遺伝子,新しい蛋白質機能およびヒトとマウスにおける新しい生物学的役割【JST・京大機械翻訳】
Authors: Fini M. Elizabeth, Jeong Shinwu, Gong Haiyan, Martinez-Carrasco Rafael, M V Laver Nora, Hijikata Minako, Keicho Naoto, Argueeso Pablo
Journal: Progress in Retinal and Eye Research (2020)
Effect of Ventral vs Dorsal Spinal Surgery in Patients With Cervical Spondylotic Myelopathy
Authors: Hiroyuki Inose, Toshitaka Yoshii, Atsushi Okawa
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>TCF7L2</i> Genetic Variants Do Not Influence Insulin Sensitivity or Secretion Indices in Autoantibody-Positive Individuals at Risk for Type 1 Diabetes
Authors: Maria J. Redondo, Megan V. Warnock, Ingrid M. Libman, Laura E. Bocchino, David Cuthbertson, Susan Geyer, Alberto Pugliese, Andrea K. Steck, Carmella Evans-Molina, Dorothy Becker, Jay M. Sosenko, Fida Bacha
Journal: Diabetes Care (2021)

We aimed to test whether type 2 diabetes (T2D)-associated
Bispecific Antibodies on Hematological Malignancies: A Novel Mechanism of Action That May Contribute to Therapeutic Efficacy
Authors: Daniel Primo, Pilar Hernandez, Javier de la Serna, Josep-Maria Ribera, Susana Vives, Juan Bergua, Jaime Perez de Oteyza, Josefina Serrano, Julian Gorrochategui, Vicente María Luisa, David Martínez-Cuadron, Pau Montesinos, Joaquin Martinez Lopez, Joan Ballesteros
Journal: Blood (2017)
CD40 stimulation as a molecular adjuvant for cancer vaccines and other immunotherapies
Authors: Timothy N. J. Bullock
Journal: Cellular and Molecular Immunology (2021)

Abstract The substantial advances attained by checkpoint blockade immunotherapies have driven an expansion in the approaches used to promote T cell access to the tumor microenvironment to provide targets for checkpoint immunotherapy. Inherent in any T cell response to a tumor antigen is the capacity of dendritic cells to initiate and support such responses. Here, the rationale and early immunobiology of CD40 as a master regulator of dendritic cell activation is reviewed, with further contextualization and appreciation for the role of CD40 stimulation not only in cancer vaccines but also in other contemporary immune-oncology approaches.
Toward predicting CYP2D6-mediated variable drug response from <i>CYP2D6</i> gene sequencing data
Authors: Maaike van der Lee, William G. Allard, Rolf H. A. M. Vossen, Renée F. Baak-Pablo, Roberta Menafra, Birgit A. L. M. Deiman, Maarten J. Deenen, Patrick Neven, Inger Johansson, Stefano Gastaldello, Magnus Ingelman-Sundberg, Henk-Jan Guchelaar, Jesse J. Swen, Seyed Yahya Anvar
Journal: Science Translational Medicine (2021)

A neural network model trained on full CYP2D6 gene sequences increases the ability to predict CYP2D6-mediated tamoxifen metabolism.
The Hand as a Mirror of Systemic Disease.
Journal: Annals of Internal Medicine (1964)

The human hand is a fascinating subject, an actor of many roles and disguises: the man in miniature, revealing its owner's story.Here is a book which sets out to teach us how best to examine it.This book has had an immediate appeal to everyone who has seen it.All doctors are, from time to time, called upon to see patients quickly, when facilities and time for a full general examination are missing.A guide to what could be regarded as "how-not-to-miss-systemic-diseasewithout-undressing-the-patient" will obviously have a wide market.The book is excellently printed, beauti- ully bound, and most of the pictures are clear and com-
A review in radiomics: Making personalized medicine a reality via routine imaging
Authors: Julien Guiot, Akshayaa Vaidyanathan, Louis Deprez, Fadila Zerka, Denis Danthine, Anne‐Noelle Frix, Philippe Lambin, Fabio Bottari, Nathan Tsoutzidis, Benjamin Miraglio, Sean Walsh, Wim Vos, Roland Hustinx, Marta Ferreira, Pierre Lovinfosse, Ralph T.H. Leijenaar
Journal: Medicinal Research Reviews (2021)

Radiomics is the quantitative analysis of standard-of-care medical imaging; the information obtained can be applied within clinical decision support systems to create diagnostic, prognostic, and/or predictive models. Radiomics analysis can be performed by extracting hand-crafted radiomics features or via deep learning algorithms. Radiomics has evolved tremendously in the last decade, becoming a bridge between imaging and precision medicine. Radiomics exploits sophisticated image analysis tools coupled with statistical elaboration to extract the wealth of information hidden inside medical images, such as computed tomography (CT), magnetic resonance (MR), and/or Positron emission tomography (PET) scans, routinely performed in the everyday clinical practice. Many efforts have been devoted in recent years to the standardization and validation of radiomics approaches, to demonstrate their usefulness and robustness beyond any reasonable doubts. However, the booming of publications and commercial applications of radiomics approaches warrant caution and proper understanding of all the factors involved to avoid "scientific pollution" and overly enthusiastic claims by researchers and clinicians alike. For these reasons the present review aims to be a guidebook of sorts, describing the process of radiomics, its pitfalls, challenges, and opportunities, along with its ability to improve clinical decision-making, from oncology and respiratory medicine to pharmacological and genotyping studies.
Chronic fatigue syndrome and long covid: individualisation, not compartmentalisation
Authors: Russell S Malcolm
Journal: BMJ (2021)

Newman’s investigation of chronic fatigue syndrome and long covid supports the development of specialised multidisciplinary support for patients with long covid.1 But compartmentalisation of a problem like chronic fatigue syndrome can sometimes miss the point.

Dysregulated systems, by their nature, cannot be manipulated into functionality, so the clinical modelling of a system disturbance …
ブファリンはステロイド受容体活性化補助因子SRC-3およびSRC-1の強力な小分子阻害剤である
Authors: Wang Ying, M Lonard David, Yu Yang, Chow Dar-Chone, G Palzkill Timothy, Wang Jin, QI Ruogu, J Matzuk Alexander, Song Xianzhou, Madoux Franck, Hodder Peter, Chase Peter, R Griffin Patrick, Zhou Suoling, Liao Lan, XU Jianming, W O’Malley Bert
Journal: Cancer Research (2014)
Percutaneous DLC-Based Total Cavopulmonary Assist Achieves 96-Hour Survival in Lethal Cavopulmonary Failure Sheep
Authors: Li Li, Jingkun Wang, Guangfeng Zhao, Stephen Topaz, David Morales, Ajit Yoganathan, Cherry Ballard-Croft, Joseph B. Zwischenberger, Dongfang Wang
Journal: Journal of the American College of Cardiology (2021)
Src/lck inhibitor dasatinib reversibly switches off cytokine release and T cell cytotoxicity following stimulation with T cell bispecific antibodies
Authors: Gabrielle Leclercq, Hélène Haegel, Anneliese Schneider, Anna Maria Giusti, Estelle Marrer-Berger, Christophe Boetsch, Antje-Christine Walz, Vesna Pulko, Johannes Sam, John Challier, Cristiano Ferlini, Alex Odermatt, Pablo Umaña, Marina Bacac, Christian Klein
Journal: Journal for ImmunoTherapy of Cancer (2021)

T cell engagers are bispecific antibodies recognizing, with one moiety, the CD3ε chain of the T cell receptor and, with the other moiety, specific tumor surface antigens. Crosslinking of CD3 upon simultaneous binding to tumor antigens triggers T cell activation, proliferation and cytokine release, leading to tumor cell killing. Treatment with T cell engagers can be associated with safety liabilities due to on-target on-tumor, on-target off-tumor cytotoxic activity and cytokine release syndrome (CRS). Tyrosine kinases such as SRC, LCK or ZAP70 are involved in downstream signaling pathways after engagement of the T cell receptor and blocking these kinases might serve to abrogate T cell activation when required (online supplemental material 1). Dasatinib was previously identified as a potent kinase inhibitor that switches off CAR T cell functionality.Using an in vitro model of target cell killing by human peripheral blood mononuclear cells, we assessed the effects of dasatinib combined with 2+1 T cell bispecific antibodies (TCBs) including CEA-TCB, CD19-TCB or HLA-A2 WT1-TCB on T cell activation, proliferation and target cell killing measured by flow cytometry and cytokine release measured by Luminex. To determine the effective dose of dasatinib, the Incucyte system was used to monitor the kinetics of TCB-mediated target cell killing in the presence of escalating concentrations of dasatinib. Last, the effects of dasatinib were evaluated in vivo in humanized NSG mice co-treated with CD19-TCB. The count of CD20+ blood B cells was used as a readout of efficacy of TCB-mediated killing and cytokine levels were measured in the serum.Dasatinib concentrations above 50 nM prevented cytokine release and switched off-target cell killing, which were subsequently restored on removal of dasatinib. In addition, dasatinib prevented CD19-TCB-mediated B cell depletion in humanized NSG mice. These data confirm that dasatinib can act as a rapid and reversible on/off switch for activated T cells at pharmacologically relevant doses as they are applied in patients according to the label.Taken together, we provide evidence for the use of dasatinib as a pharmacological on/off switch to mitigate off-tumor toxicities or CRS by T cell bispecific antibodies.
Neuronal-driven glioma growth requires Gαi1 and Gαi3
Authors: Yin Wang, Yuan-yuan Liu, Min-bin Chen, Kai-Wen Cheng, Li-na Qi, Zhi-qing Zhang, Ya Peng, Ke-ran Li, Fang Liu, Gang Chen, Cong Cao
Journal: Theranostics (2021)

Neuroligin-3 (NLGN3) is necessary and sufficient to promote glioma cell growth.The recruitment of Gαi1/3 to the ligand-activated receptor tyrosine kinases (RTKs) is essential for mediating oncogenic signaling.Methods: Various genetic strategies were utilized to examine the requirement of Gαi1/3 in NLGN3-driven glioma cell growth.Results: NLGN3-induced Akt-mTORC1 and Erk activation was inhibited by decreasing Gαi1/3 expression.In contrast ectopic Gαi1/3 overexpression enhanced NLGN3-induced signaling.In glioma cells, NLGN3-induced cell growth, proliferation and migration were attenuated by Gαi1/3 depletion with shRNA, but facilitated with Gαi1/3 overexpression.Significantly, Gαi1/3 silencing inhibited orthotopic growth of patient-derived glioma xenografts in mouse brain, whereas forced Gαi1/3-overexpression in primary glioma xenografts significantly enhanced growth.The growth of brain-metastatic human lung cancer cells in mouse brain was largely inhibited with Gαi1/3 silencing.It was however expedited with ectopic Gαi1/3 overexpression.In human glioma Gαi3 upregulation was detected, correlating with poor prognosis. Conclusion:Gαi1/3 mediation of NLGN3-induced signaling is essential for neuronal-driven glioma growth.
The geroscience agenda: Toxic stress, hormetic stress, and the rate of aging
Authors: Elissa S. Epel
Journal: Ageing Research Reviews (2020)

Geroscience offers a counterpoint to the challenged pursuit of curing diseases of aging, by focusing on slowing the biological aging process for extended healthspan earlier in life. Remarkable progress has led this field toward animal trials and the next challenge lies with translation to humans. There is an emerging number of small human trials that can take advantage of new models integrating behavioral and social factors. Understanding dynamic aging mechanisms, given the powerful social determinants of aging (Crimmins, 2020) and human variability and environmental contexts (Moffitt, 2020), will be critical. Behavioral and social factors are intrinsic to aging. Toxic stressors broadly defined can lead to stress-acceleration of aging, either directly impacting aging processes or by shaping poor behavioral health, and underlie the socioeconomic disparities of aging. In contrast, hormetic stressors, acute intermittent stressors of moderate intensity, can produce stress resilience, the ability for quick recovery and possibly rejuvenation of cells and tissues. Although health research usually examines static biomarkers, aging is reflected in dynamic ability to recover from challenges pointing to new interventions and targets for examining mechanisms. A fuller model incorporating stress resilience provides innovative biobehavioral interventions, both for bolstering response to challenges, such as COVID-19, and for improving healthspan.
Morphological Subtype According to the FAB Classification Correlates with Molecular Subtype Using Genomic Risk Classification Based on Somatic Mutation Profiles in Normal Karyotype AML
Authors: Jae-Sook Ahn, Hyeoung-Joon Kim, Yeo-Kyeoung Kim, Seung-Shin Lee, Seo-Yeon Ahn, Sung-Hoon Jung, Deok-Hwan Yang, Je-Jung Lee, Seunghyun Choi, Chul Won Jung, Jun-Ho Jang, Heeje Kim, Joon Ho Moon, Sang Kyun Sohn, Yoojin Lee, Jong-Ho Won, Sung-Hyun Kim, Taehyung Kim, Zhaolei Zhang, Dennis Kim
Journal: Blood (2017)