tbuckley/cabot-search huggingface dataset:
Divergence between refractoriness of His-Purkinje system and ventricular muscle with abrupt changes in cycle length.
Authors: SDenker, M HLehmann, RMahmud, CGilbert, MAkhtar
Journal: Circulation (1983)

The concept that refractoriness of the His-Purkinje system (HPS) and ventricular muscle both vary directly with cycle length is based on observations during the use of constant cycle length. During abrupt changes in ventricular cycle length, refractoriness of the ventricular muscle is known to reflect the cumulative durations of preceding cycle lengths. The effect of such changes on retrograde refractoriness of the HPS is not known. In this study refractoriness of ventricular muscle and of the HPS was evaluated in 30 patients with normal intraventricular conduction by the ventricular extrastimulus (V2) technique during constant cycle length (method I) and during abrupt cycle length changes (method II). During method II the cycle length immediately before V2 was identical to the constant cycle length of method I and therefore was designated as the reference cycle length (CLR); however, the cycle length preceding (CLP) CLR was either longer than CLR (method IIA) by 100 to 300 msec in 11 patients or shorter ...
Digitalis-induced augmentation of cardiopulmonary baroreflex control of forearm vascular resistance.
Authors: TImamura, ATakeshita, TAshihara, KYamamoto, SHoka, MNakamura
Journal: Circulation (1985)

We sought to determine whether digitalis augments cardiopulmonary baroreflex control of forearm vascular resistance in normal young men. Cardiopulmonary baroreceptor input was reduced with lower body negative pressure (LBNP) at 10 and 20 mm Hg, which decreased central venous pressure but did not alter blood pressure or heart rate. Decreases in forearm blood flow and increases in forearm vascular resistance with LBNP were greater after administration of lanatoside C (Cedilanid) than before, and the slope of the regression line relating changes in central venous pressure and those in forearm vascular resistance was steeper after lanatoside C. Vasoconstrictor responses to the cold pressor test did not differ before and after lanatoside C, which suggested that augmented responses to LBNP after the drug were not caused by a generalized change in reflex control. These results suggest that lanatoside C augments the tonic inhibitory influence of cardiopulmonary baroreceptors in normal men.
Demonstration that the atria, ventricles, and lungs each are responsible for a tonic inhibition of the vasomotorcenter in the dog.
Authors: GMancia, D EDonald
Journal: Circulation Research (1975)

To localize the areas of the cardiopulmonary region involved in tonic inhibition of the vasomotor center, anesthetized dogs were subjected to sinoaortic denervation and diaphragmatic vagotomy. Afferent vagal nerve traffic was interrupted in the neck by cooling. With the venous return taken from the venae cavae, oxygenated extracorporeally, and returned to the aorta, the heart was removed, leaving the ventilated lungs (condition 1), and the lungs and the ventricles were removed, leaving the beating atria (condition 3). With the venous return taken from the pulmonary arteries, oxygenated extracorporeally, and returned to the left atrium, the lungs were removed, leaving the intact working heart (condition 2), and the lungs were removed and the atria were denervated, leaving the working innervated ventricles (condition 4). Vagal cooling increased aortic pressure by 25 plus or minus 2 (SE) mm Hg in condition 1, by 36 plus or minus 2 mm Hg in condition 2, by 29 plus or minus 2 mm Hg in condition 3, and by 29 pl...
Copper loading of hearts increases postischemic reperfusion injury.
Authors: S RPowell, DHall, AShih
Journal: Circulation Research (1991)

We studied the role of copper as a potential mediator of postischemic reperfusion injury in the isolated, perfused rat heart. Hearts were equilibrated with Krebs-Henseleit buffer for 10 minutes and then loaded with copper by way of perfusion with buffer containing 20 microM copper(II)-bis-histidial for 30 minutes. Control hearts were perfused with Krebs-Henseleit buffer alone during the loading period. Hearts than were washed with buffer for 10 minutes and subjected to 20 minutes of normothermic global ischemia followed by 30 minutes of reperfusion. Atomic absorption spectroscopy revealed a 67% increase in total copper content in loaded hearts by the end of the wash. By the end of the 30-minute period of reperfusion, control hearts demonstrated a 50-60% recovery of myocardial function as determined by peak systolic pressure, contractility, and heart rate. In contrast, copper-loaded hearts exhibited virtually no functional recovery within the 30-minute time period. Using salicylate as a probe, we determine...
Phase I study of AMG 160, a half-life extended bispecific T-cell engager (HLE BiTE immune therapy) targeting prostate-specific membrane antigen, in patients with metastatic castration-resistant prostate cancer (mCRPC).
Authors: Ben Tran, Lisa Horvath, Matthew Rettig, Karim Fizazi, Martijn P. Lolkema, Tanya B. Dorff, Richard Greil, Jean-Pascal H. Machiels, Karen A. Autio, Sylvie Rottey, Nabil Adra, Rohan Garje, Felicia Roncolato, Scott T. Tagawa, Shahrokh F. Shariat, Mark Salvati, Shirley Poon, Hosein Kouros-Mehr
Journal: Journal of Clinical Oncology (2020)

TPS5590 Background: Prostate-specific membrane antigen (PSMA) is a clinically validated therapeutic target for the imaging and treatment of mCRPC. AMG 160 is an HLE BiTE immune therapy designed to redirect T cells to cancer cells by binding to PSMA on cancer cells and CD3 on T cells. BiTE immune therapy leads to direct tumor cell killing, T-cell activation and expansion, and the creation of a pro-inflammatory tumor microenvironment. Combining AMG 160 with a PD-1 inhibitor may enhance antitumor activity by enabling sustained T-cell-dependent killing of tumor cells in the inflamed tumor microenvironment. Methods: NCT03792841 is a phase I study of AMG 160 as monotherapy (part 1) and in combination with pembrolizumab (part 2) in men with histologically/cytologically confirmed mCRPC who are refractory to a novel hormonal therapy (abiraterone, enzalutamide, and/or apalutamide) and have failed 1–2 taxane regimens (or are medically unsuitable or have refused taxanes), who have ongoing castration with total serum testosterone ≤ 50 ng/dL, and have evidence of progressive disease. Patients who received prior PSMA radionuclide therapy may be eligible. Patients with CNS metastases, leptomeningeal disease, spinal cord compression, or active autoimmune disease will be excluded. Primary objectives are to evaluate safety and tolerability and determine the maximum tolerated dose (MTD) or recommended phase II dose (RP2D) of AMG 160 given as monotherapy or in combination with pembrolizumab. Secondary objectives are to characterize pharmacokinetics and preliminary antitumor activity. Exploratory objectives include evaluation of potential pharmacodynamic and patient selection biomarkers, immunogenicity, and patient-reported pain and functional outcomes. The part 1 dose exploration will determine the MTD/RP2D of AMG 160. The part 1 dose expansion will confirm the safety and tolerability of the MTD/RP2D. The part 2 dose exploration will estimate the MTD/RP2D of AMG 160 in combination with pembrolizumab. Evaluation of preliminary antitumor activity will be based on RECIST 1.1 with Prostate Cancer Working Group 3 modifications, PSA response, CTC response, progression-free survival (radiographic and PSA), and overall survival. PSMA PET/CT and FDG PET/CT imaging will be used for evaluation of exploratory objectives. The study opened in February 2019 and is currently recruiting patients into both part 1 and part 2. Clinical trial information: NCT03792841 .
Transfer of human myocarditis into severe combined immunodeficiency mice.
Authors: P LSchwimmbeck, CBadorff, H PSchultheiss, B EStrauer
Journal: Circulation Research (1994)

Severe combined immunodeficiency (SCID) mice possess neither T nor B lymphocytes and are thus suitable recipients for lymphocytes of different species. Because autoimmune mechanisms are suspected in the pathogenesis of myocarditis (MC), we attempted to determine whether peripheral blood lymphocytes (PBLs) from patients with MC could be transferred into SCID mice and whether they had an autoimmunologic effect. Groups of three mice each were injected intraperitoneally with up to 50 million PBLs from five MC patients with autoantibodies against the adenine nucleotide translocator (ANT), a myocardial autoantigen. The PBLs from three healthy blood donors were used as controls. After 60 days, human PBLs could be demonstrated in the peripheral blood of the SCID mice transfused with the PBLs of MC patients, representing up to 9.9% of the peripheral blood mononuclear cells. The transfused SCID mice sera showed human immunoglobulin levels of up to 3 mg/mL, both IgG and IgM. Autoantibodies against ANT were present i...
In older adults, adding fall-risk screening with targeted interventions to mailed advice did not reduce fractures
Authors: Eric B. Larson
Journal: Annals of Internal Medicine (2021)

ACP Journal ClubApril 2021In older adults, adding fall-risk screening with targeted interventions to mailed advice did not reduce fracturesEric B. Larson, MD, MPHEric B. Larson, MD, MPHKaiser Permanente WA Health Research Institute, Seattle, Washington, USA (E.B.L.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJ202104200-046 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationLamb SE, Bruce J, Hossain A, et al. Screening and intervention to prevent falls and fractures in older people. N Engl J Med. 2020;383:1848-59. https://pubmed.ncbi.nlm.nih.gov/33211928Clinical Impact RatingsGIM/FP/GP: Geriatrics: Public Health: References1 Bhasin S, Gill TM, Reuben DB, et al. A randomized trial of a multifactorial strategy to prevent serious fall injuries. N Engl J Med. 2020;383:129-40. [PMID: 32640131] Google Scholar2 Tricco AC, Thomas SM, Veroniki AA, et al. Comparisons of interventions for preventing falls in older adults: a systematic review and meta-analysis. JAMA. 2017;318:1687-99. [PMID: 29114830] Google Scholar Author, Article, and Disclosure InformationAffiliations: Kaiser Permanente WA Health Research Institute, Seattle, Washington, USA (E.B.L.)Disclosures: The commentator has disclosed no conflicts of interest. The form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M20-7315.This article was published at Annals.org on 6 April 2021. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics April 2021Volume 174, Issue 4Page: JC46KeywordsElderlyExerciseFallsPrimary careResearch assessmentRisk managementStatistical dataVisual impairmentsWalking ePublished: 6 April 2021 Issue Published: April 2021 Copyright & PermissionsCopyright © 2021 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Plasma lipoproteins and progression of coronary artery disease evaluated by angiography and clinical events.
Authors: N RPhillips, DWaters, R JHavel
Journal: Circulation (1993)

BACKGROUNDThere is considerable evidence that remnants of triglyceride-rich lipoproteins may be particularly atherogenic.METHODS AND RESULTSLevels of lipoprotein lipids and of apolipoprotein B in low-density lipoproteins were measured in 335 men and women enrolled in a study in which quantitative coronary angiography was carried out at 2-year intervals. Clinical events related to coronary disease occurred in 129 patients during the trial and in the subsequent follow-up period of 4 to 6 years. In multivariate analysis controlled for a number of nonlipid risk factors, high-density lipoprotein cholesterol was inversely related to the mean percentage increase in coronary artery stenosis in both men and women. Neither plasma triglycerides nor low-density lipoprotein cholesterol, triglycerides, or apolipoprotein B was related to change in stenosis, but a measure of remnants of triglyceride-rich lipoproteins, which included cholesterol in intermediate-density lipoproteins, was directly related to lesion progress...
The TRITON clinical trial programme: Evaluation of the PARP inhibitor rucaparib in patients (Pts) with metastatic castration-resistant prostate cancer (mCRPC) associated with homologous recombination deficiency (HRD)
Authors: S. Chowdhury, W. Abida, J. Arranz Arija, G. Daugaard, K. Fizazi, E. Gez, A. Heidenreich, F. Joly Lobbedez, R. McDermott, A.S. Merseburger, J.M. Piulats Rodriguez, B. Sautois, S. Sridhar, C.N. Sternberg, S. Watkins, A. Simmons, S. Shetty, A. Golsorkhi, C.J. Ryan, H. Scher
Journal: Annals of Oncology (2017)
Innate Interferons and Plasmacytoid Dendritic Cells constrain Th2 Cytokine Responses to Rhinoviruses: a Regulatory Mechanism with Relevance to Asthma
Authors: J.W. Upham, M.L. Carroll, J.G. Burel, A.L. Pritchard
Journal: Journal of Allergy and Clinical Immunology (2012)
Perspectives on systolic hypertension. The Framingham study.
Authors: W BKannel, T RDawber, D LMcGee
Journal: Circulation (1980)

Diastolic hypertension has been widely and justifiably accepted as a cause of cardiovascular mortality. However, it has also been accepted that the cardiovascular sequelae of hypertension derive chiefly from the diastolic component. Because systolic and diastolic pressure are usually highly correlated it is not easy to dissociate the effects of each. Statistical analysis suggests that systolic pressure is actually the more potent contributor to cardiovascular sequelae. Even isolated systolic pressure elevation is associated witn an excess cardiovascular mortality. At low diastolic pressures (i.e., less than 95 mm Hg), risk rises with the level of systolic pressure. Also, isolated systolic hypertension is most ominous in the elderly, in whom it is highly prevalent. Isolated systolic hypertension was related to the occurrence of direct complications as well as to atherosclerotic sequelae. It was also associated with excess mortality, taking into account rigid vessels as judged from pulse-wave recordings. ...
Hypercontractile cardiac states simulating hypertrophic cardiomyopathy.
Authors: P CCome, B HBulkley, Z DGoodman, G MHutchins, BPitt, N JFortuin
Journal: Circulation (1977)

Hypertrophic cardiomyopathy (HCM) or idiopathic hypertrophic subaortic stenosis (IHSS) has been defined as an autosomal dominant myocardial disease characterized by specific physical findings, echocardiographic features, asymmetric septal hypertrophy and disordered myocardial architecture. Echocardiographic and scintiphotographic studies failed to reveal evidence of asymmetric septal hypertrophy in four patients with systolic anterior movement of the mitral valve and the typical ausculatory and peripheral pulse abnormalities characteristic of HCM. Postmortem examimination in one patient demonstrated mild concentric left ventricular hypertrophy and a normal arrangement of myocardial muscle fibers. These observations in four patients demonstrate that both systolic anterior movement of the mitral valve and the physical findings characteristic of HCM are not specific for the autosomal dominant myocardial disease characterized by asymmetric septal hypertrophy and abnormal septal histology.
Normal exercise capacity in patients with severe left ventricular dysfunction: compensatory mechanisms.
Authors: R LLitchfield, R EKerber, J WBenge, A LMark, JSopko, R KBhatnagar, M LMarcus
Journal: Circulation (1982)

About one-third of patients who have severe left ventricular dysfunction can achieve normal levels of exercise. To elucidate the mechanisms that permit this to occur, we studied six patients with severe left ventricular dysfunction (average left ventricular ejection fraction 17 +/- 2.5% [mean +/- SEM]) who achieved nearly normal levels of exercise tolerance (greater than 11 minutes of treadmill exercise, Sheffield protocol). All patients had normal pulmonary function at rest and during exercise. Hemodynamics were measured at rest and during supine and upright exercise. The major mechanisms of the preserved exercise capacity in these patients were chronotropic competence, ability to tolerate elevated wedge pressures (33 +/- 3 mm Hg) without dyspnea, ventricular dilation, and increased levels of plasma norepinephrine at rest and during exercise. Also, whereas peripheral vascular resistance was unchanged during supine exercise, it decreased by 50% during similar levels of upright exercise. As a consequence, ...
Radiofrequency catheter ablation of Mahaim fibers at the tricuspid annulus.
Authors: L SKlein, F KHackett, D PZipes, W MMiles
Journal: Circulation (1993)

BACKGROUNDThe purpose of this study was to test the feasibility of radiofrequency catheter ablation of Mahaim fibers at the tricuspid annulus.METHODS AND RESULTSFour patients who fulfilled criteria for having Mahaim fibers and preexcited reciprocating tachycardia underwent radiofrequency catheter ablation. Three patients had atriofascicular connections, and one patient had an atrioventricular connection. The mean age was 27 years (age range, 11-48 years). All patients had highly symptomatic tachycardias, producing syncope in one patient and presyncope in the remaining three patients. Symptoms were present for a mean of 13 years (range, 4-23 years). All pathways conducted only anterogradely, and preexcitation resulted in a left bundle branch block QRS morphology. Adenosine caused block in the accessory pathway in the three patients in whom it was tested. The stimulus to delta interval increased by 75 msec (range, 35-90 msec) during rapid atrial pacing. The atrial insertion of the Mahaim fiber was in the ri...
Glomerular filtration rate in schoolgirls with covert bacteriuria.
Authors: K Verrier Jones, A W Asscher, E R Verrier Jones, K Mattholie, K Leach, G M Thomson
Journal: BMJ (1982)

Clearance of technetium-99m-labelled diethylenetriaminepenta-acetic acid was used to measure total and individual kidney glomerular filtration rates in 48 girls with covert bacteriuria. The mean (+/- SD) of the total rates of 18 girls with scarred kidneys (99 +/- 24 ml/min/1.73 m2) was significantly (0.005 greater than p greater than 0.002) lower than that in 30 girls with unscarred kidneys (119 +/- 18 ml/min/1.73 m2). This reduction in glomerular filtration was related to the loss of kidney substance associated with scarring rather than to vesicoureteric reflux. The glomerular filtration rate was unrelated to the duration of bacteriuria. These findings suggest that in girls aged 4 and over neither vesicoureteric reflux nor covert bacteriuria contributes to the progression of kidney damage.
An ultrasound Doppler technique for the noninvasive determination of the pressure gradient in the Björk-Shiley mitral valve.
Authors: JHolen, SSimonsen, TFrøysaker
Journal: Circulation (1979)

The accuracy in determining the pressure gradient in the Bjork-Shiley mitral implant from noninvasive ultrasound Doppler data was explored in nine adult patients. Manometric and ultrasound data were collectd simultaneously, and identical diastolic periods were used to compare the manometric gradient (delta Pm) with the gradient obtained from ultrasound data (delta Pu). In the nine patients the mean diastolic value of delta Pm ranged from 2-12.5 mm Hg and the difference between the mean diastolic values of delta Pm and delta Pu was 0.3 +/- 1.0 mm Hg(SD). The results of the investigation indicated that the method is accurate and reliable in the nonivasive determination of the mean diastolic gradient in the Bjork-Shiley mitral implant.
Persistent responsiveness of the neonatal ductus arteriosus in immature lambs: a possible cause for reopening of patent ductus arteriosus after indomethacin-induced closure.
Authors: R IClyman, DCampbell, M AHeymann, FMauray
Journal: Circulation (1985)

Reopening of the ductus arteriosus after successful indomethacin-induced closure has become a major problem with indomethacin treatment. In full-term human newborns and lambs, the ductus behaves like ischemic tissue after its initial constriction. Its ability to continue to relax or contract depends on the amount of left-to-right shunt through the ductus lumen. To see if ductus constriction in preterm lambs would produce the same loss of ductus responsiveness, we delivered 42 lambs by cesarean section and ventilated them for 6.6 +/- 0.5 (+/- SE) hr. We measured ductus arteriosus resistance and left-to-right shunt with the use of radionuclide-labeled microspheres. After the hemodynamic measurements were obtained, the ductus was studied in vitro. Immature lambs were more likely to have reactive ductus (after their initial ductus constriction) than were more mature lambs. This was due to a diminished degree of ductus constriction as well as persistence of ductus responsiveness in immature lambs when compared...
Shall The Journal be Removed to Washington?
Authors: A. M. Vail
Journal: JAMA (1891)

<h3>To the Editor:</h3> —It seems strange that the whole membership of the American Medical Association should be so aroused over the question of the removal of the home ofThe Journal, if it is to be such a gain as some would make it appear. Is it possible that Washington City can furnish us so much better editorial material and the Association not find it out until it has been told to us by themselves or their allies in<i>intrigant?</i> When a question of so much moment as the resigning of so important a journal to an ignominious death to furnish a stepping-stone for somebody to raise themselves into greater prominence is to be met, it seems as if the whole membership ought to be questioned, and each allowed himself to answer. A selfish motive, cloaked as this was at birth, cannot expect to meet with any other answer from
TCTAP A-020 Prognostic Impact of Residual SYNTAX Score After Successful Percutaneous Coronary Intervention of Left Main Coronary Artery Bifurcational Stenosis
Authors: Batmyagmar Khuyag, Oyunkhand Buyankhishig, Bum-Erdene Batbayar, Surenjav Chimed, Lkhagvasuren Zundui
Journal: Journal of the American College of Cardiology (2021)
Retraction Note: HGF and TGFβ1 differently influenced Wwox regulatory function on Twist program for mesenchymal-epithelial transition in bone metastatic versus parental breast carcinoma cells
Authors: Paola Bendinelli, Paola Maroni, Emanuela Matteucci, Maria Alfonsina Desiderio
Journal: Molecular Cancer (2020)

This article has been retracted. Please see the retraction notice for more detail: https://doi.org/10.1186/s12943-015-0389-y
Reactive Infectious Mucocutaneous Eruption Associated With SARS-CoV-2 Infection
Authors: Zachary E. Holcomb, Sadaf Hussain, Jennifer T. Huang, Sophia Delano
Journal: JAMA Dermatology (2021)

This case report describes a 17-year-old patient with confirmed SARS-CoV-2 infection with erosions of the vermilion lips and hard palate, circumferential erythematous erosions of the periurethral glans penis, and small vesicles on the trunk and upper extremities.
Radiolabeled acetate as a tracer of myocardial tricarboxylic acid cycle flux.
Authors: D BBuxton, MSchwaiger, ANguyen, M EPhelps, H RSchelbert
Journal: Circulation Research (1988)

The kinetics of [1-14C]acetate oxidation in isolated perfused rat hearts have been determined over a range of perfusion conditions. Effluent measurements demonstrated that 14CO2 cleared biexponentially over 50 minutes after bolus injection of [1-14C]acetate into normoxic hearts perfused with 5 mM glucose and 10 mU/ml insulin. The clearance half-time (t1/2) for the predominant initial clearance phase was 3.1 +/- 0.5 minutes (n = 4). MVO2 was varied over a fourfold range by hypoxia and phenylephrine stimulation (t1/2, 7.2 +/- 1.2 and 2.2 +/- 0.2 minutes, respectively) and in the presence of alternate substrates (lactate, 2 mM; DL-3-hydroxybutyrate, 20 mM; and palmitate, 0.1 mM), which did not modify either tricarboxylic acid (TCA) cycle flux or acetate kinetics. A good correlation (r = 0.93) was observed between k, the rate constant for the initial phase of 14CO2 clearance, and TCA cycle flux, estimated from oxygen consumption. In contrast to results with [1-14C]acetate, lactate (2 mM) increased t1/2 for 14...