tbuckley/cabot-search huggingface dataset:
Sixty seconds on . . . nasal vaccines
Authors: Elisabeth Mahase
Journal: BMJ (2022)

Sixty seconds on . . . nasal vaccines Elisabeth Mahase Haven't my nostrils been through enough?Now, now.You must admit the nasal swab has proved invaluable in the pandemic.And it seems vaccine developers are interested in this orifice too.Trials on 12 potential nasal vaccine candidates against SARS-CoV-2 are currently underway.1 Lancaster University intranasal vaccine offers promise to block covid-19 where it starts.www.lancaster.ac.uk
Effect of a Novel Online Group-Coaching Program to Reduce Burnout in Female Resident Physicians
Authors: Tyra Fainstad, Adrienne Mann, Krithika Suresh, Pari Shah, Nathalie Dieujuste, Kerri Thurmon, Christine D. Jones
Journal: JAMA Network Open (2022)

Female resident physicians are disproportionately affected by burnout, which can have serious consequences for their well-being and career trajectory. Growing evidence supports the use of professional coaching to reduce burnout in resident physicians, yet individual coaching is resource intensive and infeasible for many training programs.
PANCREATIC SOLID MASSES: SHOULD WE USE ENDOSCOPIC ULTRASOUND FINE-NEEDLE ASPIRATION WITHOUT RAPID ONSITE EVALUATION?
Authors: M. João, D. Brito, L. Elvas, S. Alves, M. Areia, S. Saraiva, A.T. Cadime
Journal: Endoscopy (2022)

Aims Current ESGE guideline recommends fine-needle aspiration (FNA) and biopsy (FNB) equally for sampling of solid pancreatic masses, however, suggests FNB needles when rapid onsite evaluation (ROSE) is not available. We aimed to compare diagnostic accuracy of cytology, cellblock and both of samples obtained by FNA in the absence of ROSE.
92MO Neoadjuvant nivolumab (NIVO) + palbociclib (PALBO) + anastrozole (ANA) for estrogen receptor-positive (ER+)/human epidermal growth factor receptor 2-negative (HER2−) primary breast cancer (BC): CheckMate 7A8
Authors: G. Jerusalem, A. Prat, R.F. Salgado, M. Reinisch, C. Saura, M. Ruiz Borrego, P. Nikolinakos, J. Filian, F. Ades, N. Huang, A. Mazzei-Abba, S.M. Tolaney
Journal: Annals of Oncology (2022)
174P Clinical effectiveness and safety of olaparib in BRCA-mutated, HER2-negative metastatic breast cancer in a real-world setting: Phase IIIb LUCY final analysis
Authors: J. Balmana, P.A. Fasching, S. Delaloge, Y.H. Park, A. Eisen, H. Bourgeois, Z. Kemp, T. Jankowski, J. Sohn, S. Aksoy, C.V. Timcheva, T-W. Park-Simon, A. Anton Torres, E. John, K. Baria, G. Walker, K.A. Gelmon
Journal: Annals of Oncology (2022)
CLIP WITH RUBBER BAND MODIFICATION FOR DYNAMIC TRACTION IN COLONIC ENDOSCOPIC SUBMUCOSAL DISSECTION (ESD)
Authors: J.I. Alves da Silva, D. Falcão, S. Ponte, R. Marcos-Pinto, I. Pedroto, R. Küttner-Magalhães
Journal: Endoscopy (2022)

63-year-old-woman referred to ESD due to 40-mm-laterally-spreading-tumor, nongranular, Paris 0-Is+IIa, JNET-type-2B, consistent with residual lesion from previous resection, with tattoo adjacent, in the descending colon. Partial mucosal incision was done. Inadequate submucosal layer exposure was noted despite pocket-creation method and underwater strategy. After complete circumferential incision, a clip grasping a rubber-band with 3nylon rings (handmade with fishing line)attached, was applied to the lesion. One nylon ring was grasped, secured to the opposite wall, and then cut with a loop cutter after ESD. Another clip grasping a remaining ring was applied in a different location in the colonic wall, readjusting traction.
BRUSH CYTOLOGY IN ERCP PATIENTS – FEATURES AND PERFORMANCE AS A DIAGNOSIS TOOL
Authors: M. Topala, V. Ionescu, R. Iacob, C. Gheorghe
Journal: Endoscopy (2022)

Aims Brush cytology is widely used in endoscopic retrograde cholangiopancreatography (ERCP) for the evaluation of indeterminate biliary strictures, although its moderate sensitivity represents a challenge in clinical practice. We aim to evaluate the performance of brush cytology as a diagnosis test for neoplastic strictures, as well as factors associated with malignancy in brush cytology results.
TT-Mars: structural variants assessment based on haplotype-resolved assemblies
Authors: Jianzhi Yang, Mark J.P. Chaisson
Journal: Genome biology (2022)

Abstract Variant benchmarking is often performed by comparing a test callset to a gold standard set of variants. In repetitive regions of the genome, it may be difficult to establish what is the truth for a call, for example, when different alignment scoring metrics provide equally supported but different variant calls on the same data. Here, we provide an alternative approach, TT-Mars, that takes advantage of the recent production of high-quality haplotype-resolved genome assemblies by providing false discovery rates for variant calls based on how well their call reflects the content of the assembly, rather than comparing calls themselves.
CHROMOENDOSCOPY WITH IODINE-POTASSIUM IODINE SOLUTION IMPROVES THE DETECTION OF EOSINOPHILIC ESOPHAGITIS
Authors: K.D.-C. Pham, S.S. Lauritzen, E. Tjora, H. Sætran, O.H. Gilja, J.G. Hatlebakk, R.F. Havre
Journal: Endoscopy (2022)

Aims Eosinophilic esophagitis (EoE) is a chronic immune-mediated condition characterized by eosinophilic infiltration of the esophageal mucosa. Endoscopic findings in EoE may be non-specific. The diagnosis is confirmed on histology. Multiple biopsies from≥2 segments are generally recommended but are occasionally negative due to a patchy distribution of EoE. This study aimed to evaluate whether chromoendoscopy with Iodine-Potassium iodine (IPIS) in the esophagus can improve the detection of EoE.
Feno differentiates epithelial gene expression clusters: Exploratory analysis from the MESOS randomized controlled trial
Authors: Sarah Diver, Sriram Sridhar, Latifa C. Khalfaoui, Richard J. Russell, Claire Emson, Janet M. Griffiths, Melissa de los Reyes, Da Yin, Gene Colice, Christopher E. Brightling
Journal: Journal of Allergy and Clinical Immunology (2022)

Understanding how asthma biomarkers relate to gene expression signatures could help identify drivers of pathogenesis.This post hoc exploratory analysis of the phase II tralokinumab trial MESOS (ClinicalTrials.gov identifier NCT02449473) aimed to profile baseline airway inflammation in patients with moderate-to-severe asthma.The T2 and T17 gene expression signatures, 3-gene mean and 5-gene mean, were calculated through transcriptomic analysis of baseline bronchial brushing samples. Clustering analysis using these signatures identified 3 distinct inflammatory subgroups: T2LOW/T17HIGH (n = 33), T2HIGH/T17LOW (n = 10), and T2LOW/T17LOW (n = 27).Fractional exhaled nitric oxide (Feno) levels were highest for T2HIGH/T17LOW and lowest for T2LOW/T17HIGH (median = 52.0 [range 42.5-116.3] and median = 18.8 [range 6.6-128.6] ppb, respectively; P = .003). High Feno levels were strongly correlated with high T2 gene expression (Spearman ρ = 0.5537; P < .001). Individual genes differentially expressed in patients with elevated levels of Feno, blood and bronchial submucosal eosinophil counts, and IgE level were explored, with cystatin SN (CST1) being the most upregulated gene in all subgroups (4.49- to 34.42-fold upregulation across clinically defined subgroups with high biomarker expression).Feno level may be useful to differentiate patients with T2 or T17 gene expression. Elevated Feno levels are associated with high CST1 expression.
INTESTINAL PREPARATION FOR CAPSULE ENDOSCOPY, DOES IT IMPROVE WITH SIMETHICONE?
Authors: M.M. Díaz Alcázar
Journal: Endoscopy (2022)

Methods A retrospective descriptive study. Review of 30 procedures. In 15 the preparation was only 8-hour fast. In another 15 the patients also received 100mg of oral simethicone. Solid intake is restarted after 4 hours. The preparation is categorized as adequate or inadequate according to the adequacy assessment of Brotz.
CONTRAST MEDIUM INJECTION THROUGH HOT-AXIOS STENT: SMALL TRICK, GREAT SAFETY FOR ENDOSCOPIC ULTRASOUND-GUIDED GASTROENTEROSTOMY (PRELIMINARY RESULTS)
Authors: M. Heilmaier, R.M. Schmid, M. Abdelhafez
Journal: Endoscopy (2022)

Aims Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) is a promising technique for management of gastric outlet obstruction. One of the major challenges regarding this technique is the loss of sonographic visualization when puncturing the gastric and intestinal wall with the electrocautery tip of the Hot-AXIOS-stent. This leads to increased risk of stent misdeployment and thus to complications like peritonitis. Injection of contrast medium through the wire-channel of the stent under fluoroscopic guidance can confirm correct positioning of the stent in the small intestine after the puncture and before it is deployed. The aim of this study was to assess the feasibility and efficacy of the technique.
CONTRIBUTION OF ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY IN LITHIASIS PATHOLOGY IN THE ELDERLY OVER 75 YEARS : RESULTS OF A RETROSPECTIVE STUDY
Authors: S. Rokhsi, T. Addajou, S. Mrabti, A. Benhamdane, A. Sair, A. Touibi, R. Berrida, I. El koti, F. Rouibaa, A. Benkirane, H. Seddik
Journal: Endoscopy (2022)

Aims The aim is to determine the particularities and safety of ERCP in patients over 75 years old by comparing its results with those of younger subjects.
SUCCESSFUL REMOVAL OF A BURIED OVER-THE-SCOPE CLIP IN THE ESOPHAGEAL WALL
Authors: A. Kuellmer, M. Schiemer, J. Mueller, A. Schmidt
Journal: Endoscopy (2022)

We performed an ESD on a patient with a barrett‘s adenocarcinoma of the distal esophagus. Resection was successful (T1a, L0, V0, Pn0; R0), but an OTSC had to be placed in the resection surface due to massive bleeding. Eight weeks later, the patient presented with severe dysphagia, caused by inflammation and scaring due to the buried OTSC. To overcome the stenosis and to faciliate radiofrequency ablation of the remaining barrett‘s esophagus, the decision for removal was made. A follow-up examination 4 weeks later showed no stenosis and an almost complete mucosal healing, so radiorequency ablation can be performed.
DUAL EMISSION LASER TREATMENT AND ARGON PLASMA COAGULATION IN SMALL BOWEL VASCULAR LESIONS ABLATION: A PILOT STUDY
Authors: G.E. Tontini, A. Rimondi, L. Scaramella, M. Topa, R. Penagini, M. Vecchi, L. Elli
Journal: Endoscopy (2022)

Aims The 1.9/1.5μmDEELT is a recent technology with promising results in treating gastrointestinal bleedings. In this manuscript, we describe our experience with this tool in ablating small bowel angioectasias through a double balloon enteroscope, comparing clinical outcomes with a matched cohort of Argon Plasma Coagulation (APC)-treated patients.
CORRELATION BETWEEN PORTAL HYPERTENSIVE GASTROPATHY AND SEVERITY OF CIRRHOSIS
Authors: A. Hassine, S. Mrabet, R. Tababi, R. Harbi, I. Akkari, A. Hassine, E. Ben Jazia
Journal: Endoscopy (2022)

Aims Portal hypertensive gastropathy (PHG) is a common endoscopic finding in cirrhotic patients. its relation with the severity of liver disease is controversial. The aim of this study was to determine the association of PHG with cirrhosis severity.
POST-POLYPECTOMY COLORECTAL CANCER RISK IN IMMUNOCHEMICAL FAECAL TEST SCREENING PROGRAMS
Authors: G. Antonelli, M. Zorzi, J. Battagello, C. Hassan
Journal: Endoscopy (2022)

Aims Post-Faecal Immunochemical Test (FIT) colonoscopy represents a highly disease-enriched setting, where nearly 1/3 of all examinations harbour an advanced adenoma. Post-polypectomy endoscopic surveillance is one of the major drivers of endoscopic services work overload but its efficacy in terms of CRC risk reduction can be limited. Aim of our study was to investigate the post-polypectomy CRC incidence and mortality risk in a well-defined screening population of FIT+subjects after resection of low- (LRA) or high-risk adenomas (HRA).
8P An immunological signature to predict outcome in patients with triple-negative breast cancer with residual disease after neoadjuvant chemotherapy
Authors: C. Blaye, E. Darbo, M. Debled, V. Brouste, V. Vélasco, C. Pinard, I. Pellegrin, A. Tarricone, M. Arnedos, J. Commeny, H. Bonnefoi, C. Larmonier, G. Macgrogan
Journal: Annals of Oncology (2022)
Increase in BNP in Response to Endothelin-Receptor Antagonist Atrasentan Is Associated With Incident Heart Failure
Authors: J. David Smeijer, Jeroen Koomen, Donald E. Kohan, John J.V. McMurray, George L. Bakris, Ricardo Correa-Rotter, Fan-Fan Hou, James L. Januzzi, Dalane W. Kitzman, Daniel M. Kolansky, Hirofumi Makino, Vlado Perkovic, Sheldon Tobe, Hans-Henrik Parving, Dick de Zeeuw, Hiddo J.L. Heerspink
Journal: JACC Heart Failure (2022)

The endothelin receptor antagonist atrasentan reduced the risk of kidney failure in patients with type 2 diabetes mellitus and chronic kidney disease (CKD) in the SONAR (Study of Diabetic Nephropathy with Atrasentan) trial, although with a numerically higher incidence of heart failure (HF) hospitalization. The purpose of this study was to assess if early changes in B-type natriuretic peptide (BNP) and body weight during atrasentan treatment predict HF risk. Participants with type 2 diabetes and CKD entered an open-label enrichment phase to assess response to atrasentan 0.75 mg/day. Participants without substantial fluid retention (>3 kg body weight increase or BNP increase to >300 pg/mL), were randomized to atrasentan 0.75 mg/day or placebo. Cox proportional hazards regression was used to assess the effects of atrasentan vs placebo on the prespecified safety outcome of HF hospitalizations. Among 3,668 patients, 73 (4.0%) participants in the atrasentan and 51 (2.8%) in the placebo group developed HF (HR: 1.39; 95% CI: 0.97-1.99; P = 0.072). In a multivariable analysis, HF risk was associated with higher baseline BNP (HR: 2.32; 95% CI: 1.81-2.97) and percent increase in BNP during response enrichment (HR: 1.46; 95% CI: 1.08-1.98). Body weight change was not associated with HF. Exclusion of patients with at least 25% BNP increase during enrichment attenuated the risk of HF with atrasentan (HR: 1.02; 95% CI: 0.66-1.56) while retaining nephroprotective effects (HR: 0.58; 95% CI: 0.44-0.78). In patients with type 2 diabetes and CKD, baseline BNP and early changes in BNP in response to atrasentan were associated with HF hospitalization, highlighting the importance of natriuretic peptide monitoring upon initiation of atrasentan treatment. (Study Of Diabetic Nephropathy With Atrasentan [SONAR]; NCT01858532)
SAME-DAY MORNING-ONLY DOSING OF 1L NER1006, A POLYETHYLENE GLYCOL BOWEL PREPARATION, NEARLY DOUBLES THE CHANCE OF HIGH-QUALITY CLEANSING VERSUS STANDARD 2L-POLYETHYLENE GLYCOL AND ASCORBATE
Authors: J. Manning, M. Epstein, C. Allen, M.A. Álvarez-González
Journal: Endoscopy (2022)

Aims NER1006 is a 1L polyethylene glycol (PEG)-based bowel preparation with approved morning-only dosing in adults across Europe and the United States. NER1006 is indicated for bowel cleansing starting 4–6 hours before colonoscopy, safeguarding sleep and nutritional status. We compared the colon-cleansing efficacy of morning-only NER1006 versus overnight split dosing with standard 2LPEG and ascorbate (2LPEG).
KNOWLEDGE, PERCEPTIONS AND BEHAVIOURS OF ENDOSCOPISTS TOWARDS THE USE OF ARTIFICIAL INTELLIGENCE AIDED COLONOSCOPY
Authors: S. Tham, F.H Koh, S. Endoscopy Centre, E.-K. Teo, C.-L. Lin, F.-J. Foo
Journal: Endoscopy (2022)

Aims Recent developments in artificial intelligence (AI) systems have enabled advancements in endoscopy. Deep learning systems, using convolutional neural networks, have allowed for real-time AI-aided detection of polyps with higher sensitivity than the average endoscopist. However, not all endoscopists welcome the advent of AI systems.
COMBINED ENDOSCOPIC-FLUOROSCOPIC ASSESSMENT OF A SUPRADIAPHRAGMATIC CAVITY (MIS)DIAGNOSED AS COVID-19-RELATED LUNG ABSCESS
Authors: A. Koffas, D. Chougias, A. Papaefthymiou, I. Dimeas, K. Tourlakopoulos, E. Karakasidis, R. Moisidou, K. Argyriou, A. Kapsoritakis, S. Potamianos, A. Manolakis
Journal: Endoscopy (2022)

An inpatient treated for COVID-19 was referred for esophagogastroduodenoscopy,after cross-sectional imaging demonstrated a ‘left-lower-lobe lung abscess’,spontaneously draining into the stomach.Gastroscopy revealed a paradoxical torsion of the proximal stomach and engulfment of converging proximal gastric folds through a diaphragmatic defect.Contrast was infused into the ‘presumed abscess cavity’ via a through-the-scope catheter.Upon fluoroscopy,no contrast leak was documented.The presence of a well-demarcated cavity became evident.The endoscope was advanced into the cavity revealing ulcerated gastric mucosa.The findings were compatible with the occurrence of a ‘paraesophageal’ hiatal hernia,following traumatic diaphragmatic laceration during a car accident 14 months ago.The patient was referred for surgical management.
EFFICACY OF A NOVEL PEPTIDE HAEMOSTATIC GEL IN PREVENTION OF BLEEDING POST ENDOSCOPIC RESECTION OF LARGE DUODENAL ADENOMAS
Authors: M. Woolley, D. Subhaharan, M. Bassan, J. Hwang, J. Huang, S. John
Journal: Endoscopy (2022)

Aims Post procedural bleeding (PPB) after endoscopic mucosal resection (EMR) of duodenal lesions is significant and can occur in 5-25% of patients. Several factors affect this including lesion location, type of resection, lesion size and comorbidities. Endoscopic removal of ampullary lesions or large lesions (>10 mm) have high risk of delayed bleeding. We aimed to assess the efficacy of a novel self-assembling peptide matrix gel in preventing PPB after resection of large duodenal adenomas.
REDUCING HEALTH CARE LOAD DURING THE COVID-19 PANDEMIC: BIODEGRADABLE STENTS MAKE FOLLOW-UP ENDOSCOPIES VANISH
Authors: A. Maieron, L. Erhart, P. Pramhofer, R. Schöfl, G. Spaun, E. Steiner, F. Wewalka, A. Ziachehabi
Journal: Endoscopy (2022)

Aims A major advantage of biodegradable stents is the reduction of follow-up endoscopies for removal. In light of limited interventional and surgical resources due to COVID-19, we used ARCHIMEDES stents (ABPS) for a range of pancreatic and biliary diseases. This study aimed to evaluate technical and clinical safety.
CARBON FOOTPRINT DETERMINATION OF SINGLE-USE ENDOSCOPE
Authors: P. López-Muñóz, R. Martín-Cabezuelo, V. Pons-Beltrán, G. Vilariño, P.A. Betín, I. Tort, A. Vidaurre, V. Lorenzo-Zúñiga
Journal: Endoscopy (2022)

Aims The current COVID-19 crisis has forced us to increase the presence of non-reusable instruments which makes mandatory to analyze our ecological footprint. Gastrointestinal endoscopy represents one of the largest procedure volumes of single-use consumables.One-time use endoscopes and duodenoscopes already exists and are gaining presence in the GI industry. We aimed to analyze carbon footprint of these instruments to determine its environmental effect.
SMALL BOWEL POLYPOSIS. ROLE OF MOTORIZED SPIRAL ENTEROSCOPY
Authors: R. Muñoz Pérez, L. Compañy Catalá, F. Ruiz Gómez, M. Roger Ibáñez, A. Rodríguez Angulo, L. Guilabert Sanz, E. Álvarez Arroyo, J. Martínez Sempere, L. Medina Prado, B. Martínez Moreno, C. Mangas Sanjuán, J.R. Aparicio Tormo
Journal: Endoscopy (2022)

A 61-year-old female on anticoagulant treatment presented with anaemia and positive FOBT. No findings on gastroscopy and colonoscopy. Capsule endoscopy showed an angiodysplasia in jejunum and four polypoid lesions in ileum.
LARGE SUPERFICIAL SQUAMOUS CELL CARCINOMA IN THE SETTING OF ACHALASIA TREATED BY ENDOSCOPIC SUBMUCOSAL DISSECTION: PARTICULAR FEATURES OF SUPERFICIAL CARCINOMA ON STASIS RELATED ESOPHAGEAL HYPERKERATOSIS
Authors: L. Mesureur, R. Yared, L. Verset, J.-L. Van Laethem, H. Louis, J. Deviere, A. Lemmers
Journal: Endoscopy (2022)

Results A 69-years-old man presented dysphagia and weight loss for several years was referred after the discovery of a 6mm lesion with high-grade dysplasia.
REAL-TIME COMPUTER AIDED DETECTION-ASSISTED COLONOSCOPY ELIMINATES DIFFERENCES IN ADENOMA DETECTION RATE BETWEEN TRAINEE AND EXPERIENCED ENDOSCOPISTS
Authors: F. Cocomazzi, M. Gentile, I. Loconte, A. Mileti, R. Paolillo, A. Marra, S. Castellana, T. Mazza, A. Di Leo, F. Perri, G. Biscaglia
Journal: Endoscopy (2022)

Aims Adenoma detection rate (ADR) is a well-accepted quality indicator of screening colonoscopy. In recent years, artificial intelligence (AI) showed its added value in terms of ADR and adenoma miss rate (AMR). To date, there are no studies evaluating the impact of AI on the performance of trainee endoscopists (TE). Aim of this study was to evaluate whether AI may eliminate any difference in ADR or AMR between TE and experienced endoscopists (EE).
In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan
Authors: Rui Ribeiro, Joana C. Macedo, Madalena Costa, Vladimir Ustiyan, Anastasia V. Shindyapina, Alexander Tyshkovskiy, Rita N. Gomes, José Pedro Castro, Tanya V. Kalin, Francisco Vasques-Nóvoa, Diana S. Nascimento, Sergey E. Dmitriev, Vadim N. Gladyshev, Vladimir V. Kalinichenko, Elsa Logarinho
Journal: Nature Aging (2022)
Covid-19: Stockpiling antivirals risks repeating Tamiflu mistakes, experts warn
Authors: Gareth Iacobucci
Journal: BMJ (2022)

Covid-19: Stockpiling antivirals risks repeating Tamiflu mistakes, experts warnThe UK government has made a huge investment in antivirals to fight covid, but some experts are concerned the waste and overspending of the 2000s will recur.Gareth Iacobucci reports Gareth IacobucciThe government's Antivirals Taskforce has procured more antivirals per population than any other country in Europe, with over 4.98 million courses ordered so far. 1 Included within this is 2.75 million courses of Pfizer's oral antiviral drug Paxlovid (a combination of nirmatrelvir and ritonavir tablets).Andrew Hill, senior visiting research fellow in the Department of Pharmacology and Therapeutics at the University of Liverpool, has estimated, using publicly available drug prices in the US, that the UK has spent £2.2bn (€2.6bn; $2.8bn) so far on procuring antivirals."There's a vast amount of money involved," he told The BMJ. "As usual, all government contracts are confidential, so maybe they got some discount.But if the UK paid US prices, which it has with vaccines, then it has spent around £2.2bn on antivirals for covid.
Is it time to include older adults in inflammatory bowel disease trials? A call for action
Authors: Sophie Vieujean, Bénédicte Caron, Vipul Jairath, Athanase Benetos, Silvio Danese, Edouard Louis, Laurent Peyrin-Biroulet
Journal: The Lancet Healthy Longevity (2022)

The therapeutic management of older patients with inflammatory bowel disease (IBD) is challenging, particularly because of the absence of evidence-based guidelines for these patients, who seem to frequently be excluded from clinical trials. In this systematic review we investigated the exclusion of older patients with IBD from phase 3 studies registered on PubMed and ClinicalTrials.gov, by assessing the upper limit of age exclusion criteria and the percentage of patients older than 65 years included in the trials. Exclusion criteria other than age were also recorded, and comorbidities were analysed separately. Our review of 222 phase 3 studies shows that older patients are frequently excluded from IBD clinical trials because of their age, which was used as an exclusion criterion in 129 (58%) of the 222 assessed trials. Of the 32 trials that detailed the percentage of included patients who were 65 years or older, only 763 (5·4%) patients of the 14 124 patients included were older than 65 years. In addition to age, patients were also excluded because of comorbidities (mainly renal, hepatic, and cardiovascular, and used as an exclusion criterion in 76% of trials), a history of dysplasia (45% of trials), and previous treatment for IBD (19% of trials). We propose a three-step process that should enable the inclusion of all older patients in IBD clinical trials, regardless of their age, comorbidities, and frailty.
LOW RISK OF HYPOKALEMIA IN ADULTS TREATED WITH 1 LITER POLYETHYLENE GLYCOL (PEG)–BASED BOWEL PREPARATION NER1006: POOLED ANALYSIS OF 2 RANDOMIZED PHASE 3 TRIALS
Authors: B. Cash, C. Oneto, C. Allen, D. Poppers, R. Bisschops
Journal: Endoscopy (2022)

Aims Data suggest a risk of hypokalemia in patients taking PEG-based bowel preparations. The current aim was to evaluate the incidence of hypokalemia in patients who received the 1L PEG-based bowel preparation NER1006 compared with other bowel preparations.