tbuckley/cabot-search huggingface dataset:
A First in Surgical Devices for Transvaginal Hysterectomy
Authors: Rebecca Voelker
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Early loss of postextrasystolic potentiation in acutely ischemic myocardium: evaluation by contrast two-dimensional echocardiography.
Authors: TForce, A JKemper, CCohen, A FParisi
Journal: Circulation (1985)

Studies in animals with acutely ischemic hearts have suggested that postextrasystolic potentiation (PESP) may predict the viability of dysfunctional myocardium. Most of these data have been obtained with sonomicrometers and therefore the presence and extent of PESP throughout the entire region at risk has not been defined. In this study we used contrast two-dimensional echocardiography (2DE) to define region at risk in vivo, and then with quantitative 2DE we examined the proportion of the region at risk that demonstrated PESP, the degree of the potentiation, and the time course of this response. The region at risk was divided into a central (inner 50%) and two peripheral (25% each) ischemic zones. Adjacent contrast-enhanced myocardium was divided into near and far border zones that were equal in size to the adjacent peripheral ischemic zone. Systolic thickening was analyzed within each zone along multiple radii at 5, 30, and 120 min after coronary occlusion. PESP was absent in the central ischemic zone at...
Hypothermic coronary venous phased retroperfusion: a closed-chest treatment of acute regional myocardial ischemia.
Authors: SMeerbaum, R VHaendchen, ECorday, MPovzhitkov, M CFishbein, JY-Rit, T WLang, TUchiyama, NAosaki, JBroffman
Journal: Circulation (1982)

Hypothermic synchronized retroperfusion (HSRP) was applied in closed-chest dogs after acute coronary occlusion to determine whether this intervention can significantly retard the otherwise rapidly developing irreversible ischemic injury. The left anterior descending coronary artery (LAD) was occluded for 3 hours in 22 dogs and for 6 hours in 16 dogs. Starting 30 minutes after occlusion, HSRP was applied during maintained coronary occlusion in 21 dogs. The remaining dogs served as untreated controls. Arterial blood was cooled to 20 degrees C and retroperfused in diastole into the regional coronary veins. Hemodynamics, contrast cineangiography and two-dimensional echocardiography were measured sequentially. Glycogen-depleted ischemic areas and necrotic zones were delineated in transverse slices of the left ventricle. Untreated controls dogs further deteriorated; in contrast, HSRP between 30 minutes and 3- and 6-hour LAD occlusion significantly reduced the rate-pressure product (21.3 +/- 4.0% or 26.8 +/- 8.2...
The Efficacy of Endocuff Vision in Endoscopic Mucosal Resection to the Full Extent of the Colon - a Feasibility Case Series
Authors: P Nicolaou, M Fragaki, M Velegraki, A Mpitouli, A Psistakis, G Paspatis
Journal: Endoscopy (2021)

Aims There are limited data indicating that ENDOCUFF VISIONTM is safe and useful to facilitate complex polypectomy in the sigmoid colon by retracting the colonic folds [1]. However, data concerning its safety and efficacy in cases of large sessile/flat polyps to the full extent of the colon and particularly in the right colon, are lacking.
Early Discharge of Newborns
Authors: Joseph V. Cook
Journal: JAMA (1997)

<h3>To the Editor.</h3> —Two articles<sup>1,2</sup>concerning early discharge of newborns came to contradictory conclusions concerning whether early discharge is associated with increased risk of rehospitalization, as discussed in the accompanying Commentary.<sup>3</sup>This prompted us to relate the experience of MedSpan, a Connecticut-based, provider-sponsored managed care organization, with a voluntary early discharge program offered to our policyholders and the effect of Connecticut state legislation. Mothers and their healthy infants who met physician-established criteria and volunteered to be discharged from the hospital within 30 hours of normal vaginal delivery were offered 2 skilled nursing visits at home, 16 hours of nanny care, and 1 extra pediatric office visit. We analyzed utilization of services among 77 consecutive mothers who used the program during a 19-month period beginning January 1, 1996 (unpublished data, August 1997). We found that 1 mother did not use any nursing visits, 5 used 1 visit, 70 used 2 visits, and 1
Exercise-induced upward shift of diastolic left ventricular pressure-volume relation in patients with dilated cardiomyopathy. Effects of beta-adrenoceptor blockade.
Authors: HSato, MHori, HOzaki, HYokoyama, KImai, MMorikawa, HTakeda, MInoue, TKamada
Journal: Circulation (1993)

BACKGROUNDThe effectiveness of beta-blocker therapy for dilated cardiomyopathy (DCM) may be attributed to the inhibition of detrimental effects on the failing heart of sympathetic stimulation during exertion. However, the harmful effects of activity as well as the protective effects of beta-blockers have not been demonstrated. Diastolic ventricular function is known to be sensitive to transient myocardial metabolic insult. In this study, we investigated the effect of modest exercise with or without beta-blockade on the diastolic left ventricular pressure-volume (P-V) relation in patients with DCM.METHODS AND RESULTSThe diastolic left ventricular P-V relation was obtained by high-fidelity pressure measurements and digital subtraction left ventriculography at rest and immediately after modest supine bicycle exercise in 12 patients with DCM. The effects of intravenous administration of 0.1 mg/kg propranolol on resting and exercise P-V relations were studied. The end-diastolic and lowest left ventricular pres...
Targeting the resolution pathway of inflammation using Ac2–26 peptide-loaded PEGylated lipid nanoparticles for the remission of rheumatoid arthritis
Authors: Xianyan Qin, Liming He, Donghao Fan, Wenlang Liang, Qin Wang, Jiyu Fang
Journal: Asian Journal of Pharmaceutical Sciences (2021)

Rheumatoid arthritis (RA) is a common autoimmune disease characterized by joint inflammation and immune dysfunction. Although various therapeutic approaches have been utilized for the treatment of RA in clinical applications, the low responsiveness of RA patients and undesired systemic toxicity are still unresolved problems. Targeting the resolution pathway of inflammation with pro-resolving mediators would evoke the protective actions of patient for combating the inflammation. Ac2-26, a 25-amino acid peptide derived from Annexin A (a pro-resolving mediator), has shown good efficacy in the treatment of inflammatory disorders. However, the low bioavailability of Ac2-26 peptides hinders their efficacy
Abstract 16051: Pattern and Behavior of Electrocardiographic Changes in Patients Undergoing Repair of Anomalous Aortic Origin of Coronary Arteries
Authors: Stephen B Williams, Tam Doan, Tam Dan Pham, Dana Reaves, Carlos Bonilla, Ziyad Binsalamah, Emmett D McKenzie, Christopher Caldarone, Silvana M Molossi
Journal: Circulation (2020)

Introduction: Surgical repair in anomalous aortic origin of a coronary artery (AAOCA) aims at mitigating the risk of sudden cardiac death in a subset of patients (pts). The pattern and behavior of electrocardiogram (ECG) changes in a large cohort of these pts is lacking. We aim to describe post-operative (post-op) ECG changes in this population with medium term follow up (f/u). Methods: Observational study evaluating ECGs before and after surgery to describe peri-operative changes through f/u. All patients &lt;21 years (yrs) with AAOCA were prospectively evaluated and managed following a standardized approach from 12/2012-11/2019. A subset underwent repair given high-risk features. ECGs were reviewed at 5 specific time intervals from pre-operative (pre-op) to 90-day post-op f/u. Significant findings included new ST elevation (STE), T wave inversion (TWI) and/or new q waves. Results: A total of 64 pts were identified (median age 13.7 yrs, 64% male). Two patients had evidence of STE and TWI pre-op and were not included. Of 62 pts: 47 (75%) had new STE early post-op and all but 1 had resolution at 90-day f/u; 50 (81%) had no evidence of new TWI or q waves early post-op and 96% of these remained stable at 90-day f/u. Conversely, 12 (19%) had new TWI in the early post-op: 8 had isolated changes (75% resolved at 90 days) and 4 associated with new q waves (50% resolved at 90 days). Including all ECG changes in the total cohort, 92% resolved completely at 90-day f/u. In those pts (8%) with persistent changes, none required late reintervention and all but 1 were cleared for return to exercise. All patients were alive at medium f/u of 4 yrs (IQR 2-6) with normal ventricular function. Conclusions: New STE is a common finding in the early post-op period following repair of AAOCA and is not correlated with persistent ECG changes at 90-day follow up. TWI is infrequently seen but less likely to resolve if associated with new q waves. Despite these changes in the early post-op, clinical outcomes medium-term are excellent.
AB0067 ASSOCIATION BETWEEN INTERLEUKIN-6–174 G/C POLYMORPHISMS AND VASCULITIS: A META-ANALYSIS
Authors: Jae Hyun Jung, Gwan Gyu Song, Jae-Hoon Kim, Sung Jae Choi
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> Interleukin (IL)-6 is associated with the development and progression of vasculitis, and inhibitors of this cytokine are used to treat this disease. Polymorphisms of the promoter region of IL-6 are associated with the production and expression of IL-6. <h3>Objectives</h3> The aim of this study was to perform a meta-analysis of eligible studies to derive a precise estimate of the association between IL-6 polymorphisms and susceptibility to vasculitis. <h3>Methods</h3> A meta-analysis was conducted on the associations between IL-6-174 G/C and vasculitis. The literature was searched using the PubMed and Embase databases to identify available articles in which IL-6 polymorphisms were analyzed in vasculitis patients. The associations between the -174 G/C alleles and vasculitis were estimated by evaluating odds ratio (OR) and 95% confidence interval (CI). We performed meta-analyses using the 1) allelic contrast (C vs. G), 2) recessive (CC vs. GC+GG), and 3) dominant (CC+GC vs. GG) models, and 4) heterozygote vs. dominant homozygote (GC vs. GG), 5) heterozygote vs. recessive homozygote (GC vs. CC), and 6) homozygote comparison (CC vs. GG). <h3>Results</h3> A total of 13 studies involving 1,294 vasculitis patients and 1,594 controls were considered in the meta-analysis. There were significant associations between IL-6-174 G/C polymorphisms and vasculitis in allele contrast, dominant genetic model, and heterozygote vs. dominant homozygote comparison (OR 0.80, 95% CI 0.67–0.94, <i>P</i> =0.009 and OR 0.76, 95% CI 0.63–0.92, <i>P</i> =0.005, respectively). In subgroup analysis based on subtype, there were significant associations between IL-6 polymorphisms and susceptibility in large and medium vessel vasculitis, but not in small and variable vessel vasculitis. <h3>Conclusion</h3> The GC genotype of IL-6-174 G/C was suggested by the analyses to be related to low prevalence of vasculitis, especially for large and medium vessels. <h3>References</h3> [1] Assari R, Aghighi Y, Ziaee V, Sadr M, Rahmani F, Rezaei A, Sadr Z, Moradinejad MH, Raeeskarami SR, Rezaei N. (2018) Pro-inflammatory cytokine single nucleotide polymorphisms in Kawasaki disease. Int J Rheum Dis21:1120-6. [2] Berti A, Cavalli G, Campochiaro C, Guglielmi B, Baldissera E, Cappio S, Sabbadini MG, Doglioni C, Dagna L. (2015) Interleukin-6 in ANCA-associated vasculitis: Rationale for successful treatment with tocilizumab. Semin Arthritis Rheum45:48-54. [3] Salvarani C, Casali B, Farnetti E, Pipitone N, Nicoli D, Macchioni P, Cimino L, Bajocchi G, Catanoso MG, Boiardi L. (2005) Interleukin-6 promoter polymorphism at position -174 in giant cell arteritis. J Rheumatol32:2173-7. <h3>Acknowledgement</h3> No grant or other support was received for this study. <h3>Disclosure of Interests</h3> None declared
Trastuzumab Deruxtecan in Previously Treated HER2-Positive Gastric Cancer
Authors: Kohei Shitara, Yung-Jue Bang, Satoru Iwasa, Naotoshi Sugimoto, Min-Hee Ryu, Daisuke Sakai, Hyun-Cheol Chung, Hisato Kawakami, Hiroshi Yabusaki, Jeeyun Lee, Kaku Saito, Yoshinori Kawaguchi, Takahiro Kamio, Akihito Kojima, Masahiro Sugihara, Kensei Yamaguchi
Journal: New England Journal of Medicine (2020)

Trastuzumab deruxtecan (DS-8201) is an antibody-drug conjugate consisting of an anti-HER2 (human epidermal growth factor receptor 2) antibody, a cleavable tetrapeptide-based linker, and a cytotoxic topoisomerase I inhibitor. The drug may have efficacy in patients with HER2-positive advanced gastric cancer.In an open-label, randomized, phase 2 trial, we evaluated trastuzumab deruxtecan as compared with chemotherapy in patients with HER2-positive advanced gastric cancer. Patients with centrally confirmed HER2-positive gastric or gastroesophageal junction adenocarcinoma that had progressed while they were receiving at least two previous therapies, including trastuzumab, were randomly assigned in a 2:1 ratio to receive trastuzumab deruxtecan (6.4 mg per kilogram of body weight every 3 weeks) or physician's choice of chemotherapy. The primary end point was the objective response, according to independent central review. Secondary end points included overall survival, response duration, progression-free survival, confirmed response (response persisting ≥4 weeks), and safety.Of 187 treated patients, 125 received trastuzumab deruxtecan and 62 chemotherapy (55 received irinotecan and 7 paclitaxel). An objective response was reported in 51% of the patients in the trastuzumab deruxtecan group, as compared with 14% of those in the physician's choice group (P<0.001). Overall survival was longer with trastuzumab deruxtecan than with chemotherapy (median, 12.5 vs. 8.4 months; hazard ratio for death, 0.59; 95% confidence interval, 0.39 to 0.88; P = 0.01, which crossed the prespecified O'Brien-Fleming boundary [0.0202 on the basis of number of deaths]). The most common adverse events of grade 3 or higher were a decreased neutrophil count (in 51% of the trastuzumab deruxtecan group and 24% of the physician's choice group), anemia (38% and 23%, respectively), and decreased white-cell count (21% and 11%). A total of 12 patients had trastuzumab deruxtecan-related interstitial lung disease or pneumonitis (grade 1 or 2 in 9 patients and grade 3 or 4 in 3), as adjudicated by an independent committee. One drug-related death (due to pneumonia) was noted in the trastuzumab deruxtecan group; no drug-related deaths occurred in the physician's choice group.Therapy with trastuzumab deruxtecan led to significant improvements in response and overall survival, as compared with standard therapies, among patients with HER2-positive gastric cancer. Myelosuppression and interstitial lung disease were the notable toxic effects. (Funded by Daiichi Sankyo; DESTINY-Gastric01 ClinicalTrials.gov number, NCT03329690.).
8th European Conference on Infections in Leukaemia: 2020 guidelines for the diagnosis, prevention, and treatment of invasive fungal diseases in paediatric patients with cancer or post-haematopoietic cell transplantation
Authors: Andreas H Groll, Dorothea Pana, Fanny Lanternier, Alessio Mesini, Roland A Ammann, Dina Averbuch, Elio Castagnola, Simone Cesaro, Dan Engelhard, Carolina Garcia-Vidal, Jukka Kanerva, Nicole Ritz, Emmanuel Roilides, Jan Styczynski, Adilia Warris, Thomas Lehrnbecher
Journal: The Lancet Oncology (2021)
Regurgitant jet size by transesophageal compared with transthoracic Doppler color flow imaging.
Authors: M DSmith, M RHarrison, RPinton, HKandil, O LKwan, A NDeMaria
Journal: Circulation (1991)

Combined echocardiography and Doppler color flow mapping from transthoracic imaging windows has become the standard method for the noninvasive assessment of valvular regurgitation. This study compared regurgitant jet areas by Doppler color flow imaging derived from the newer transesophageal approach with measurements obtained from conventional transthoracic apical views. Maximal regurgitant jet area determinations and an overall visual estimate of lesion severity were obtained from 42 patients who underwent color flow examination by both techniques. Seventy-three regurgitant lesions were visualized by transesophageal flow imaging: 34 mitral, 22 aortic, and 17 tricuspid jets. Transthoracic studies in the same patients revealed fewer regurgitant lesions for each valve; 20 mitral, 16 aortic, and 12 tricuspid (p = 0.0009). A comparison of maximal jet areas determined by transesophageal and transthoracic studies showed a good overall correlation (r = 0.85, SEE = 2.8 cm2) and a systematic overestimation by the ...
Sudden death after repair of tetralogy of Fallot. Electrocardiographic and electrophysiologic abnormalities.
Authors: P CGillette, M AYeoman, C EMullins, D GMcNamara
Journal: Circulation (1977)

In order to try to determine the mechanism of sudded death in patients after surgical repair of tetralogy of Fallot, electrocardiographic, intracardiac electrophysiologic, and clinical data of 51 children who had postoperative intracardiac electrophysiologic studies were reviewed. Ninety-four percent had developed right bundle branch block (RBBB) and 16 percent had additional left anterior hemiblock (LAH). Two had had transient complete A-V block (CAVB) and one had permanent CAVB. Six had a first degree A-V block and nine had premature ventricular contractions (PVC). Nine patients were found to have prolonged intra-atrial conduction times, four prolonged A-V nodal conduction, four prolonged His-Purkinje conduction, and five prolonged corrected sinus node recovery times. Patients with first degree A-V block or LAH did not have an increased incidence of abnormalities on electrophysiologic study. No patient with RBBB and LAH developed complete A-V block or died. Three of the nine patients with PVCs died, one...
Is EUS-Guided Single-Step Complete-Aspiration Useful In The Management Of Abdominal Collections?
Authors: JG Velasquez-Rodriguez, S Maisterra, J Colan Hernandez, JB Gornals
Journal: Endoscopy (2021)

Aims Most endoscopic management of abdominal collections includes Endoscopic Ultrasound (EUS)-guided transmural drainage or transpapillary drainage via ERCP. EUS-guided single-step complete-aspiration (SSCA) is little reported and there are some doubts about its real effectiveness.
In vivo myocardial kinetics of air-filled albumin microbubbles during myocardial contrast echocardiography. Comparison with radiolabeled red blood cells.
Authors: A RJayaweera, NEdwards, W PGlasheen, F SVillanueva, R DAbbott, SKaul
Journal: Circulation Research (1994)

Myocardial contrast echocardiography (MCE) is a new technique for assessing myocardial perfusion that uses intracoronary injections of microbubbles of air. Because these microbubbles have a mean diameter of 4.3 +/- 0.3 microns and an intravascular rheology similar to that of red blood cells (RBCs), we hypothesized that their mean myocardial transit rates recorded on echocardiography would provide an estimation of regional myocardial blood flow in the in vivo beating heart. Accordingly, blood flow to the left anterior descending coronary artery (LAD) of 12 open-chest anesthetized dogs (group I) was adjusted to 4 to 6 flows (total of 60 flows), and microbubbles and radiolabeled RBCs were injected into the LAD in a random order at each stage. The mean myocardial RBC transit rates were measured by fitting a gamma-variate function to time-activity plots generated by placing a miniature CsI2 probe over the anterior surface of the heart, and the mean myocardial microbubble transit rates were measured from time-i...
3D bioprinting of engineered breast cancer constructs for personalized and targeted cancer therapy
Authors: Majid Sharifi, Qian Bai, Mohammad Mahdi Nejadi Babadaei, Farhan Chowdhury, Mahbub Hassan, Akbar Taghizadeh, Hossein Derakhshankhah, Suliman Khan, Anwarul Hasan, Mojtaba Falahati
Journal: Journal of Controlled Release (2021)
Acute effects of nitroglycerin depend on both plasma and intracellular sulfhydryl compound levels in vivo. Effect of agents with different sulfhydryl-modulating properties.
Authors: SBoesgaard, H EPoulsen, JAldershvile, SLoft, M EAnderson, AMeister
Journal: Circulation (1993)

BACKGROUNDChanges in sulfhydryl (SH) compound availability may alter the hemodynamic effect of nitroglycerin (NTG). Data on the relation between NTG effect and thiol levels are, however, limited to in vitro experiments. The present study investigates how intracellular and extracellular changes in SH group concentrations (cysteine and glutathione [GSH]) affect the responsiveness to NTG in vivo.METHODS AND RESULTSGSH and cysteine levels in plasma, vena cava, and aorta were measured after administration of N-acetylserine (placebo, n = 6), N-acetylcysteine (NAC, extracellular and intracellular SH donor, n = 6), oxothiazolidine (OXO, intracellular SH donor, n = 6), buthionine sulfoximine (BSO, intracellular GSH-depleting agent, n = 6), BSO+NAC (n = 6), and BSO+OXO (n = 6) in chronically catheterized conscious rats. In addition, the effect of 2.5 mg NTG/kg i.v. on mean arterial pressure (MAP) was determined before and after the same treatment. NAC (5 mmol/kg i.v. for 2 hours) significantly (p < 0.05) increased ...
Shall The Journal be Removed to Washington?
Authors: G. L. Pritchett
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal