tbuckley/cabot-search huggingface dataset:
Surgeon’s Sex Affects the Number and Types of Referrals Received—We Know the System Is Broken…Now Let’s Fix It
Authors: Patricia Martinez Quinones, Caprice C. Greenberg, L. Renee Hilton
Journal: JAMA Surgery (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Comparison between R-COMP and R-CHOP in Older Patients with Diffuse Large B-Cell Lymphoma (DLBCL): A Substudy of the Elderly Project By the Fondazione Italiana Linfomi
Authors: Francesco Merli, Michele Spina, Alessandra Tucci, Luigi Rigacci, Federica Cavallo, Maria Giuseppina Cabras, Isabel Alvarez, Alberto Fabbri, Alessandro Re, Benedetta Puccini, Simone Ferrero, Sara Veronica Usai, Angela Ferrari, Emanuele Cencini, Elsa Pennese, Vittorio Ruggero Zilioli, Dario Marino, Monica Balzarotti, M. Christina Cox, Manuela Zanni, Alice Di Rocco, Arben Lleshi, Barbara Botto, Stefan Hohaus, Michele Merli, Roberto Sartori, Guido Gini, Luca Nassi, Gerardo Musuraca, Monica Tani, Chiara Bottelli, Sofia Kovalchuk, Francesca Re, Leonardo Flenghi, Anna Lia Molinari, Giuseppe Tarantini, Emanuela Chimienti, Luigi Marcheselli, Caterina Mammi, Stefano Luminari, Annalisa Arcari
Journal: Blood (2021)
Causes and Circumstances of Death: Analysis in 266 Sickle Cell Adult Patients
Authors: Anoosha Habibi, Stephanie Ngo, Keyvan Razazi, Vincent Audard, Gonzalo De Luna, Marc Michel, France Pirenne, Henri Guillet, Christian Kassasseya, Frédéric Galactéros, Armand Mekontso-Dessap, Pablo Bartolucci
Journal: Blood (2021)
A Prospective Survey to Understand the Preferences and Perspectives of Patients with Hematological Malignancies in a Tertiary Cancer Care Setting in India (CANCOV SURVEY)
Authors: Dr. Neha Sharma, Dr. Hasmukh Jain, Dr. Hemanth Muthuluri, Dr. Avinash Bonda, Dr. Manju Sengar, Dr. Jayashree Thorat, Dr. Lingaraj Nayak, Dr. Bhausaheb Bagal
Journal: Blood (2021)
TAMI-17. INDUCTION OF SYNTHETIC LETHALITY BY ACTIVATION OF MITOCHONDRIAL CLPP AND INHIBITION OF HDAC1/2 IN GLIOBLASTOMA
Authors: Trang Nguyen, Enyuan Shang, Salveena Schiffgens, Consuelo Torrini, Elena Bianchetti, Chang Shu, Hasan Orhan Akman, Varun Prabhu, Joshua Allen, Mike-Andrew Westhoff, Georg Karpel-Massler, Markus D Siegelin
Journal: Neuro-Oncology (2021)

Abstract Activation of the mitochondrial ClpP protease is an innovative therapeutic concept and the identification of synthetic lethal interactions may foster the development of novel therapies for glioblastoma (GBM). By integration of a transcriptome, metabolite and U-13C-glucose tracing analyses, we showed that activation of the mitochondrial ClpP protease through constitutively active ClpP (Y118A) or utilization of second-generation imipridone compounds (ONC206 and ONC212) in combination with genetic interference of HDAC1 and HDAC2 as well as with global (Panobinostat) and selective (Romidepsin) HDAC inhibitors caused synergistic reduction of viability in established, neuro-sphere and patient-derived xenograft (PDX) cultures of human GBM, which was mediated by interference with tricarboxylic acid cycle activity and GBM cell respiration. Notably, human astrocytes were significantly less susceptible to the combination treatment of HDAC-inhibitors and ClpP activators. The reduction of GBM viability occurred independent of TP53 status and was accompanied by activation of cell death with apoptotic features along with cleavage of caspases regulated chiefly by Bcl-xL and Mcl-1. Importantly, knockdown of the ClpP protease or ectopic expression of a ClpP D190A mutant almost completely rescued from the inhibition of oxidative energy metabolism as well as from the reduction of cellular viability by ClpP activators and the combination treatment, suggesting critical involvement of this protein. Finally, utilizing GBM PDX models, we demonstrated that the combination treatment of HDAC-inhibitors and imipridones reduced tumor growth and prolonged host survival more potently than single treatments or vehicle in vivo. Collectively, these observations suggest that the efficacy of HDAC inhibitors might be significantly enhanced through ClpP activators in model systems of human GBM.
Long-Term Safety and Efficacy of Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura (aTTP): The Post-HERCULES Study
Authors: Marie Scully, Javier de la Rubia, Katerina Pavenski, Ara Metjian, Paul Knoebl, Flora Peyvandi, Spero Cataland, Paul Coppo, Johanna A. Kremer Hovinga Strebel, Jessica Minkue Mi Edou, Rui de Passos Sousa, Filip Callewaert, Sriya Gunawardena, Julie Lin
Journal: Blood (2021)
GABAergic neuronal IL-4R mediates T cell effect on memory
Authors: Jasmin Herz, Zhongxiao Fu, Kyungdeok Kim, Taitea Dykstra, Morgan Wall, Huiping Li, Andrea Francesca Salvador, Bende Zou, Ni Yan, Susan M Blackburn, Patrick H Andrews, Dylan H Goldman, Zachary Papadopoulos, Igor Smirnov, Xinmin S Xie, Jonathan Kipnis
Journal: Neuron (2021)
Reduced Intensity Hematopoietic Cell Transplantation Improves Cerebral Hemodynamics in Children with Sickle Cell Disease
Authors: Akshay Sharma, Matthew Scoggins, Ping Zou, Amanda Kennedy, Richard Lovins, Sanjay Verma, Stacy High, Ranganatha Sitaram, Brandon M Triplett, Jane S Hankins, Zoltan Patay
Journal: Blood (2021)
Mortality comparison between the first and second/third waves among 3,795 critical COVID-19 patients with pneumonia admitted to the ICU: A multicentre retrospective cohort study
Authors: Raquel Carbonell, Silvia Urgelés, Alejandro Rodríguez, María Bodí, Ignacio Martín-Loeches, Jordi Solé-Violán, Emili Díaz, Josep Gómez, Sandra Trefler, Montserrat Vallverdú, Josefa Murcia, Antonio Albaya, Ana Loza, Lorenzo Socias, Juan Carlos Ballesteros, Elisabeth Papiol, Lucía Viña, Susana Sancho, Mercedes Nieto, Maria del Carmen Lorente, Oihane Badallo, Virginia Fraile, Fernando Arméstar, Angel Estella, Laura Sanchez, Isabel Sancho, Antonio Margarit, Gerard Moreno
Journal: The Lancet Regional Health - Europe (2021)
Impact of Molecular Features of Diffuse Large B-Cell Lymphoma on Treatment Outcomes with Anti-CD19 Chimeric Antigen Receptor (CAR) T-Cell Therapy
Authors: Brian T. Hill, Caroline J Roth, Rachel Kositsky, Tushar Dave, Cassandra Love, Matthew McKinney, Ahmed Galal, Jadee L Neff, Agrima Mian, Ellen Kendall, Sarah L. Ondrejka, Matthew Chiaramonte, Govind Bhagat, Kenneth Ofori, Ran Reshef, Alexandra E. Kovach, Tarsheen Sethi, Emily F Mason, Shakthi Bhaskar, Olalekan O. Oluwole, Christopher Pallas, Nilanjan Ghosh, Robert Ferdman, George L. Chen, Francisco J. Hernandez-Ilizaliturri, Joanna C. Zurko, Ashley Cunningham, Nirav N. Shah, Boyu Hu, Deborah M. Stephens, Monalisa Ghosh, Neil Bailey, Krish Patel, John M. Pagel, Kavya Kannamma Kannan, Eric D. Hsi, Rakhee Vaidya, Andrew Ip, Andre H. Goy, Swetha Kambhampati, Robert S. Ohgami, Charalambos Andreadis, Elizabeth Thacker, Chrissie Rozzi, Clay Parker, Lanie Happ, Sandeep S. Dave
Journal: Blood (2021)
The East Asian Parkinson Disease Genomics Consortium
Authors: Kin Y Mok, Ji-Feng Guo, Bei-Sha Tang, Huifeng Shang, Chunyu Li, Huong Thi Thanh Nguyen, Thi Thanh Huyen Vu, Anh Tuan Nguyen, Nancy Y Ip, Amy KY Fu, Fanny CF Ip, Xiaopu Zhou, Han Cao, Kin Ying Mok, John Hardy, Germaine Hiu Fai Chan, Nelson Yuk-Fai Cheung, Phillip Chan, Wing Chi Fong, Norlinah Mohamed Ibrahim, Shahrul Azmin, Nor Azian Abdul Murad, Siti Aishah Sulaiman, Siti Hajar Md Desa, Wael Mohamed, Sulev Koks, Abigail Pfaff, Lewis Singleton, Yun Joong Kim, Seok Jong Chung, Seong-Min Choi, Yu Chen, Yuewen Chen, Tao Ye, Yih-Ru Wu, Hsiu-Chuan Wu, Ruey-Meei Wu, Chin-Hsein Lin, Yu-An Su, Mong-Hsun Tsai, Tomotaka Shiraishi, Hidetomo Murakami, Renpei Sengoku, Nobutaka Hattori, Manabu Funayama, Tatsushi Toda, Wataru Satake, Kotaro Ogaki, Kenya Nishioka, Andrew Singleton, Mike Nalls, Cornelis Blauwendraat
Journal: The Lancet Neurology (2021)
Cancer cell-derived exosomal circUSP7 induces CD8+ T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC
Authors: Shi-Wei Chen, Shu-Qiang Zhu, Xu Pei, Bai-Quan Qiu, Dian Xiong, Xiang Long, Kun Lin, Feng Lu, Jian-Jun Xu, Yong-Bing Wu
Journal: Molecular Cancer (2021)

CD8+ T cells play a critical role in the innate antitumour immune response. Recently, CD8+ T cell dysfunction has been verified in various malignant cancers, including non-small cell lung cancer (NSCLC). However, the molecular biological mechanisms of CD8+ T cell dysfunction in human NSCLC are still unclear.The expression of circular ubiquitin-specific protease-7 (circUSP7) in NSCLC tissues, exosomes, and cell lines was detected by quantitative real-time polymerase chain reaction (qRT-PCR). Exosomes were isolated from the culture medium of NSCLC cells and the plasma of NSCLC patients using an ultracentrifugation method and the ExoQuick Exosome Precipitation Solution kit. The exosomes were then characterized by transmission electronic microscopy (TEM), NanoSight and western blotting. The role of circUSP7 in CD8+ T cell dysfunction was assessed by enzyme-linked immunosorbent assay (ELISA). In vivo circular RNA (circRNA) precipitation (circRIP), RNA immunoprecipitation (RIP), and luciferase reporter assays were performed to explore the molecular mechanisms of circUSP7 in CD8+ T cells. In a retrospective study, the clinical characteristics and prognostic significance of circUSP7 in NSCLC tissues were determined.The expression levels of circUSP7 were higher in human NSCLC tissues than in matched adjacent nontumour tissues. Increased levels of circUSP7 indicate poor clinical prognosis and CD8+ T cell dysfunction in patients with NSCLC. The circUSP7 found in NSCLC patient plasma is predominantly secreted by NSCLC cells in an exosomal manner, and circUSP7 inhibits IFN-γ, TNF-α, Granzyme-B and Perforin secretion by CD8+ T cells. Furthermore, circUSP7 inhibits CD8+ T cell function by upregulating the expression of Src homology region 2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2) via sponging miR-934. Finally, we show that circUSP7 may promote resistance to anti-PD1 immunotherapy in NSCLC patients.Exosomal circUSP7 is predominantly secreted by NSCLC cells and contributes to immunosuppression by promoting CD8+ T cell dysfunction in NSCLC. CircUSP7 induces resistance to anti-PD1 immunotherapy, providing a potential therapeutic strategy for NSCLC patients.
Ciprofloxacin versus ceftriaxone in the prophylaxis of infections in patients with decompensated Liver cirrhosis and hemorrhage
Authors: 김병익 ( Byung Ik Kim ), Hong Joo Kim, Yong Kyun Cho, Woo Kyu Jeon, Hong Soo Kim, Dong Joon Kim
Journal: Clinical and Molecular Hepatology (2010)

Background: There have been no trials comparing the prophylactic effect of oral quinolone and intravenous cephalosporin antibiotics and elucidating the predictive factors for the occurrence of bacterial infections in cirrhotic patients with gastrointestinal bleeding in Asian-Pacific region. Methods: One hundred thirteen patients with advanced liver cirrhosis and active gastrointestinal hemorrhage were enrolled in our study. The patients were randomly allocated into either the oral ciprofloxacin group (n=50, 500 mg every 12 hours) or the intravenous ceftriaxone group (n=63, 2.0 g per day for 7 days). Results: Proven or possible infections were significantly more frequent in the patients in the oral ciprofloxacin group (34.0%) than the intravenous ceftriaxone group (14.3%, P=0.002). The intestinal permeability index [IPI, mean (SD)] measured the day after admission was significantly higher in the patients with proven or possible infections [1.45 (0.96)] compared to the no infection group [0.46 (0.48), p<0.01]. By multivariate analysis, oral ciprofloxacin prophylaxis and higher IPI at the time of inclusion were independent and significant predictors for proven or possible infections. By receiver operating characteristic curve analysis, the best cutoff value of IPI for the prediction of the occurrence of bacterial infection was 0.62%. Conclusions: The frequency of proven or possible infections was significantly lower in the intravenous ceftriaxone group compared to the oral ciprofloxacin group. The IPI measured the day after admission is a good clinical parameter predicting the occurrence of infection in these patients.
Abstract 13456: Characterizing Changes in Quality of Life and in Older Patients With Acute Decompensated Heart Failure Enrolled in a Rehab Intervention Clinical Trial
Authors: David J Whellan, Dalane W Kitzman, Haiying Chen, Michael B Nelson, Amy M Pastva, Melissa McCarey, Pamela W Duncan, Robert J Mentz, Shelby D Reed
Journal: Circulation (2021)

Introduction: Older patients with acute decompensated heart failure (ADHF) have severely impaired QOL. We recently reported that a novel physical rehab intervention improves QOL. Here we report trajectories of improvement and relationship to participation in a rehab intervention. Methods: Patients with ADHF, regardless of EF and ≥ 60 years old were randomized to either attention control (AC) or rehab intervention (RI). Participants completed the KCCQ, a disease-specific QOL instrument, and 12-Item Short-Form Health Survey (SF-12), a general QOL instrument composed of a mental and physical composite score, at baseline (inpatient), 1 month and 3 months. Effects of the intervention were assessed using linear mixed effects models including the main effect of intervention, follow-up visit, and interaction term with adjustment for EF category, age, and sex. Results: The REHAB-HF trial enrolled 349 patients with a mean age of 72.7±8.1 years, 52% women and 49% non-white. Baseline KCCQ scores were low for both arms (Figure 1). There was a substantial increase in KCCQ score at 1 month in both arms. However, in contrast to the AC participants who showed no further improvement, RI participants continued to experience an increase in QOL at 3 months creating a significant difference between arms (p&lt; 0.01). Both SF-12 composite scores also increased in both arms at 1 month with continued improvement only in the RI arm; reaching significance for the mental composite at 1 month (50.8±1.1 vs. 46.9±1.1, p &lt; 0.01) and at 3 months (52.7±1.1 vs. 48.2±1.1, p&lt; 0.01). Conclusions: Older patients hospitalized with ADHF have severely impaired disease-specific and general QOL that improves soon after discharge. Patients receiving a novel physical rehabilitation intervention experienced an early benefit in terms of QOL that continued to improve throughout the 3 months trial period. Future studies will help determine if these benefits are sustained with longer term follow-up.
Abstract 9489: Echocardiographic Characteristics, Cardiovascular Factors, and Disease-Directed Therapy Do Not Explain Differences in Covid-19 Related Hispanic Outcomes
Authors: Joseph Isaac S Wong, Ramy Sadek, Armeen Mehrabani, Anthony Koppula, Jonathan Soverow
Journal: Circulation (2021)

Introduction: Severe coronavirus disease 2019 (COVID-19) is associated with cardiovascular injury and disparate outcomes in different ethnic groups. However, the reason for this difference has not been elucidated. Methods: A retrospective cross-sectional study was done on adult COVID-19 patients at a single center from April 2020 to January 2021. Mortality, length of stay, mechanical ventilation use, and intensive care unit (ICU) status were compared across demographic groups, echocardiographic indices, and COVID-19-specific treatments. Results: One hundred fifty patients were included. In univariate analysis, elevated cardiac biomarkers, COVID-19 directed therapies, and elevated right-sided pressures were associated with higher mortality, mechanical ventilation use, length of stay, and ICU admission. Multivariable logistic regression predicted higher mortality for Hispanic ethnicity (odds ratio, OR, 6.7) even when adjusting for advanced age (OR 5.3), mechanical ventilation use (OR 18), and right ventricular systolic pressure (OR 1.1 per 1mmHg). There were no differences in underlying comorbidities, echocardiographic indices, cardiac biomarkers, or treatments between Hispanic and non-Hispanic patients. Conclusions: Despite being a younger cohort, Hispanic patients had a higher rate of mortality even when controlling for age, biomarkers, and echocardiographic indices. This suggests Hispanic ethnicity is an independent risk factor for mortality in COVID-19 infection, highlighting an important health inequity that warrants further investigation.
VIP152, a Selective CDK9 Inhibitor, Induces Complete Regression in a High-Grade B-Cell Lymphoma (HGBL) Model and Depletion of Short-Lived Oncogenic Driver Transcripts, MYC and MCL1, with a Once Weekly Schedule
Authors: Melanie M. Frigault, Harvey Wong, Hermes Garban, Joy M. Greer, Stuart Hwang, Raquel Izumi, Amy J. Johnson, Beatrix Stelte-Ludwig, Ahmed Hamdy
Journal: Blood (2021)
A High Sensitivity aCD22 CAR Combined with aCD19 CAR to Generate Dual Targeting CAR T Cells for the Treatment of r/r B-ALL
Authors: Evangelia K Kokalaki, Biao Ma, Mathieu Ferrari, Thomas Grothier, Warren Hazelton, Somayya Manzoor, Eren Costu, Saket Srivastava, Ram Jha, Rosalind Gealy, Lukas Stanczuk, Mathew Robson, Julia Taylor, Mohamed El-Kholy, Vania Baldan, Matteo Righi, James Sillibourne, Shimobi Onuoha, Sara Ghorashian, Shaun P Cordoba, Persis J Amrolia, Martin Pule
Journal: Blood (2021)
Super-Enhancer Driven Regulation of CKS1B in Multiple Myeloma: Implications in Mediating Response to BET Inhibitor and Celmod Agent Combination
Authors: Aarif Ahsan, Ann Polonskaia, Chih-Chao Hsu, Chad C Bjorklund, Maria Ortiz Estevez, Fadi Towfic, Nizar J. Bahlis, Michael Pourdehnad, Erin Flynt, Aarif Ahsan, Anjan Thakurta
Journal: Blood (2021)
Obstructive sleep apnoea/hypopnoea syndrome and obesity hypoventilation syndrome in over 16s: summary of NICE guidance
Authors: Sharangini Rajesh, David Wonderling, Anita K Simonds
Journal: BMJ (2021)

### What you need to know

Obstructive sleep apnoea/hypopnoea syndrome (OSAHS) affects around 5% of adults in the UK, while obesity hypoventilation syndrome (OHS) is estimated to affect 0.3-0.4% of the general population.1 In addition to sleepiness, OSAHS may present with a range of symptoms including insomnia and difficulties concentrating, and it can lead to hypertension and exacerbate pre-existing cardiovascular disease. People with OHS are at higher risk of cardiovascular complications and have higher mortality compared with non-obese people.2

This article summarises the most recent recommendations from the National Institute for Health and Care Excellence (NICE) guideline for obstructive sleep apnoea/hypopnoea syndrome and obesity hypoventilation syndrome in adults (over 16 years old).3 The guideline, published in August 2021, covers diagnosis and management of OSAHS, OHS, and COPD-OSAHS overlap syndrome. This guideline summary discusses only selected recommendations on OSAHS and OHS, focusing on those most relevant to primary care. 

NICE recommendations are based on systematic reviews of best available evidence and explicit consideration of cost effectiveness. When minimal evidence is available, recommendations are based on the guideline committee’s experience and opinion of what constitutes good practice. Evidence levels for the recommendations are given in italic in square brackets.

### Obstructive sleep apnoea/hypopnoea syndrome (OSAHS)

In this condition the upper airway is narrowed or closes during sleep when muscles relax, causing under-breathing (hypopnoea) or stopping breathing …
A Predictive Endothelial-Leukemia Pre-Clinical Platform to Uncover Drug Vulnerabilities for Personalized Treatments
Authors: Luca Vincenzo Cappelli, Danilo Fiore, Jude M Phillip, Liron Yoffe, Filomena Di Giacomo, Yang Hu, Clarisse Kayembe, Michael Ginsberg, Lorena Consolino, José Gabriel Barcia Durán, Nahuel Zamponi, Ari Melnick, Francesco Boccalatte, Wayne Tam, Olivier Elemento, Sabina Chiaretti, Anna Guarini, Robin Foa, Leandro Cerchietti, Shahin Rafii, Giorgio Inghirami
Journal: Blood (2021)
FLGS-04. Fluorescence lifetime imaging (FLIm) is a dye-free, high sensitivity approach for fluorescence guided surgery in high-grade and low-grade gliomas
Authors: Orin Bloch, Alba Alfonso Garcia, Silvia Noble Anbunesan, Roberto Frusciante, Julien Bec, Laura Marcu
Journal: Neuro-Oncology (2021)

Abstract INTRODUCTION Fluorescence-guided surgery can improve tumor identification and extent of surgical resection. 5-ALA is the standard for GBM, but is limited by lack of quantitative fluorescence, a need to work in the dark, and a lack of sensitivity for low grade tumors. We have developed a novel instrument for dye-free tissue autofluorescence lifetime imaging (FLIm) to identify glioma tissue during resection. This approach utilizes time-resolved autofluorescence measurements in narrow-band channels to assess markers of tissue metabolism. Compared to intensity-based imaging of exogenous fluorophores, FLIm has greater sensitivity without dependence on background lighting. The advantages of FLIm include quantitative tissue analysis, the ability to work under full light conditions, sensitivity for high and low grade gliomas, and the potential ability to identify IDH mutational status. In this study, we validated the use of FLIm for identification of glioma tissue at tumor resection margins. METHODS FLIm was used to image tissue margins during glioma resections and compared to microbiopsies from imaged regions to correlate fluorescence with histopathology. RESULTS FLIm was applied intraoperatively to 11 GBM and 5 LGG patients (7 imaged biopsies per patient). In GBM, tumor infiltration of cortex was associated with significantly decreased fluorescence lifetime (FL) in channels 2 (470/28nm;p&amp;lt;0.05) and 3 (542/50nm;p&amp;lt;0.002). In subcortical margins, FL was inversely proportional to the density of tumor in channels 2,3 (p&amp;lt;0.05). When IDH wild-type GBMs were compared to IDH1-mutant tumors, FL was noted to be significantly longer in channel 1 (390/40nm;p&amp;lt;0.05), and trended towards longer FL in channel 2, shorter FL in channel 3. In LGG, FL was significantly correlated with tumor density in channel 2 (p&amp;lt;0.01). CONCLUSIONS FLIm is a dye-free, quantitative alternative to 5-ALA for fluorescence guided glioma resections with sensitivity to high and low-grade tumors, and the ability to predict IDH mutations in GBM. Further validation studies are on-going.
Factors Associated with Outcomes Among Refractory/Relapsed TP53-Mutated/Chromosome 17p Deletion Acute B-Cell Lymphoblastic Leukemia (B-ALL) Patients Treated with CD19-Targeted Chimeric Antigen Receptor (CAR)-T Therapy
Authors: Xian Zhang, Gailing Zhang, Wenqian Li, Yang Zhang, Tong Wang, Junfang Yang, Jingjing Li, Peihua Lu
Journal: Blood (2021)
Baseline Serum Ferritin Differentially Predicts W24 Transfusion Independence Response for Momelotinib and Ruxolitinib in Patients with Myelofibrosis
Authors: Stephen T. Oh, Aaron T. Gerds, Ruben A. Mesa, Vikas Gupta, Mei Huang, Sunhee Ro, Bryan Strouse, Barbara Jane Klencke, Srdan Verstovsek
Journal: Blood (2021)