tbuckley/cabot-search huggingface dataset:
1802MO Influence of preoperative chemoradiation on tumor-infiltrating lymphocytes in locally advanced rectal cancer: The STAR-01 cohort
Authors: L. Gnetti, F. Negri, L. Bottarelli, N. Campanini, M.E. Negru, F. Bergamo, M. Frisinghelli, G. Chiaulon, A. Tagliagambe, A. Morabito, V. Smiroldo, G.A.C. Vita, S. Tamberi, S.S. Cordio, E.M. Silini, C. Azzoni, F. Gaiani, None G.L. de’Angelis, L. Boni, C. Aschele
Journal: Annals of Oncology (2021)
1567MO COVID-19 and cancer: First report of the ESMO international, registry-based, cohort study (ESMO CoCARE)
Authors: E. Romano, S. Gennatas, J. Rogado, M. Sekacheva, D. Viñal, R. Lee, A-E. Croitoru, M. Vitorino, S.M. Khallaf, S. Susnjar, S. Widyanti, A. Cardeña, M. Djerouni, M. Rossi, D. Arnold, L. Castelo-Branco, K.J. Harrington, O.A. Michielin, G. Pentheroudakis, S. Peters
Journal: Annals of Oncology (2021)
500P Molecular features in liquid biopsy of early (EO) and late-onset colorectal cancer (LO)
Authors: J. Alcaide-Garcia, M. Benavides, M. Alvarez, I. Sevilla, I.C. Ales Diaz, M. Robles Lasarte, C. Muriel Lopez, V. Navarro Perez, A. Miranda, M. Kushnir, I. Faull, C. Fernandez de Sousa, E. Alba
Journal: Annals of Oncology (2021)
Strategies to reduce the risk of SARS-CoV-2 importation from international travellers: modelling estimations for the United Kingdom, July 2020
Authors: Samuel Clifford, Billy J Quilty, Timothy W Russell, Yang Liu, Yung-Wai D Chan, Carl A B Pearson, Rosalind M Eggo, Akira Endo, Stefan Flasche, W John Edmunds
Journal: Eurosurveillance (2021)

Background To mitigate SARS-CoV-2 transmission risks from international air travellers, many countries implemented a combination of up to 14 days of self-quarantine upon arrival plus PCR testing in the early stages of the COVID-19 pandemic in 2020. Aim To assess the effectiveness of quarantine and testing of international travellers to reduce risk of onward SARS-CoV-2 transmission into a destination country in the pre-COVID-19 vaccination era. Methods We used a simulation model of air travellers arriving in the United Kingdom from the European Union or the United States, incorporating timing of infection stages while varying quarantine duration and timing and number of PCR tests. Results Quarantine upon arrival with a PCR test on day 7 plus a 1-day delay for results can reduce the number of infectious arriving travellers released into the community by a median 94% (95% uncertainty interval (UI): 89–98) compared with a no quarantine/no test scenario. This reduction is similar to that achieved by a 14-day quarantine period (median &gt; 99%; 95% UI: 98–100). Even shorter quarantine periods can prevent a substantial amount of transmission; all strategies in which travellers spend at least 5 days (mean incubation period) in quarantine and have at least one negative test before release are highly effective (median reduction 89%; 95% UI: 83–95)). Conclusion The effect of different screening strategies impacts asymptomatic and symptomatic individuals differently. The choice of an optimal quarantine and testing strategy for unvaccinated air travellers may vary based on the number of possible imported infections relative to domestic incidence.
238P BOLERO-5: A phase II study of everolimus and exemestane combination in Chinese post-menopausal women with ER+/HER2- advanced breast cancer
Authors: Z. Shao, L. Cai, S. Wang, X. Hu, K. Shen, H. Wang, H. Li, J. Feng, Q. Liu, J. Cheng, X. Wu, X. Wang, H. Li, T. Luo, J. Liu, K. Amin, K. Slimane, Y. Qiao, Y. Liu, Z. Tong
Journal: Annals of Oncology (2021)
Assisted dying: have public opinion polls captured a cross section of all society?
Authors: Sharif Al-Ghazal
Journal: BMJ (2021)

Godlee argues for a stance of neutrality on the debate around introducing assisted suicide in the UK.1

The arguments for assisted suicide are primarily based on accommodating individual choice and control, as a means to confront fears of suffering associated with dying.

True autonomy and “choice” devoid of external influences and pressures is a fragile and philosophical concept at best, …
An evolutionary theory of music needs to care about developmental timing
Authors: Erin E Hannon, Alyssa N Crittenden, Joel S Snyder, Karli M Nave
Journal: Behavioral and Brain Sciences (2021)

Abstract Both target papers cite evidence from infancy and early childhood to support the notion of human musicality as a somewhat static suite of capacities; however, in our view they do not adequately acknowledge the critical role of developmental timing, the acquisition process, or the dynamics of social learning, especially during later periods of development such as middle childhood.
1306P Real-world data of first-line treatment with pembrolizumab for highly PD-L1 expressing NSCLC (HOT/NJLCG2001)
Authors: A. Nakamura, H. Mizugaki, Y. Ikezawa, R. Morita, K. Tateishi, K. Yokoo, T. Sumi, H. Kikuchi, Y. Kitamura, M. Morita, M. Aso, Y. Tsukita, F. Yoshiike, M. Furuta, H. Tanaka, M. Sekikawa, T. Hachiya, K. Nakamura, H. Yokouchi
Journal: Annals of Oncology (2021)
1244P Real-world EGFR and T790M testing patterns in patients from Central Eastern Europe with advanced non-small cell lung cancer: Results from a large retrospective study (REFLECT)
Authors: M. Dediu, U. Janzic, M.V. Marinca, A. Pluzanski, N. Turnsek, R. Lupu, G. Teodorescu, I. Shterev Donev
Journal: Annals of Oncology (2021)
860MO Preoperative durvalumab (D) with or without tremelimumab (T) for resectable head and neck squamous cell carcinoma (HNSCC)
Authors: M.H. Hong, C.G. Kim, D.H. Kim, S.M. Lim, B-C. Ahn, S-H. Kim, Y.M. Park, H. Park, G. Park, I. Jung, B.C. Cho, Y.W. Koh, H.R. Kim
Journal: Annals of Oncology (2021)
985P Advanced safety and efficacy data from stratum D of the phase I INSIGHT platform trial evaluating feasibility and safety of eftilagimod alpha combined with avelumab in advanced solid tumors
Authors: T.O. Goetze, M.W. Daniel, M-R. Rafiyan, D. Kiselicki, T. Habibzade, M. Schaaf, R. Eickhoff, E. Jaeger, S-E. Al-Batran
Journal: Annals of Oncology (2021)
1455P Clinical factors influencing place of death of oncology patients in palliative care in a primary care district of Cadiz
Authors: J.M. Martinez-Nieto, A. Delgado-Romero, C. Sancho-Salvatierra, M.D.M. Leon-Grima, M.J. Gomez-Plana, L. Arias-Velarde, B. Ardaiz-Flamarique, M.I. Barberan-Montiano, L. Diaz-Martinez, F.J. Perez-Cabezas, J.A. Rubio-Muñoz, F. Moreno-Castro, J. Fernandez-Rodriguez, M.A. Ramirez-Castillo, C. Tello-Meneses, P. Ruiz-Cayuso, J.M. Caparros-Garcia, A.D. Romero
Journal: Annals of Oncology (2021)
Human parainfluenza virus evolution during lung infection of immunocompromised individuals promotes viral persistence
Authors: Alexander L. Greninger, Ksenia Rybkina, Michelle J. Lin, Jennifer Drew-Bear, Tara C. Marcink, Ryan C. Shean, Negar Makhsous, Michael Boeckh, Olivia Harder, Francesca Bovier, Shana R. Burstein, Stefan Niewiesk, Bert K. Rima, Matteo Porotto, Anne Moscona
Journal: Journal of Clinical Investigation (2021)

The capacity of respiratory viruses to undergo evolution within the respiratory tract raises the possibility of evolution under the selective pressure of the host environment or drug treatment. Long-term infections in immunocompromised hosts are potential drivers of viral evolution and development of infectious variants. We showed that intrahost evolution in chronic human parainfluenza virus 3 (HPIV3) infection in immunocompromised individuals elicited mutations that favored viral entry and persistence, suggesting that similar processes may operate across enveloped respiratory viruses. We profiled longitudinal HPIV3 infections from 2 immunocompromised individuals that persisted for 278 and 98 days. Mutations accrued in the HPIV3 attachment protein hemagglutinin-neuraminidase (HN), including the first in vivo mutation in HN's receptor binding site responsible for activating the viral fusion process. Fixation of this mutation was associated with exposure to a drug that cleaves host-cell sialic acid moieties. Longitudinal adaptation of HN was associated with features that promote viral entry and persistence in cells, including greater avidity for sialic acid and more active fusion activity in vitro, but not with antibody escape. Long-term infection thus led to mutations promoting viral persistence, suggesting that host-directed therapeutics may support the evolution of viruses that alter their biophysical characteristics to persist in the face of these agents in vivo.
567O First International Randomized Study in Malignant Progressive Pheochromocytoma and Paragangliomas (FIRSTMAPPP): An academic double-blind trial investigating sunitinib
Authors: E. Baudin, B. Goichot, A. Berruti, J. Hadoux, S. Moalla, S. Laboureau, S. Noelting, C. de la Fouchardière, T. Kienitz, T. Deutschbein, S. Zovato, L. Amar, A. Tabarin, H.J. Timmers, P. Niccoli, A. Faggiano, F. Beuschlein, M. Attard, M. Texier, M. Fassnacht
Journal: Annals of Oncology (2021)
912P Results of a randomized phase II study comparing pembrolizumab with methotrexate in elderly, frail or cisplatin-ineligible patients with relapsed or metastatic squamous cell carcinoma of the head and neck (RM-SCCHN) (ELDORANDO-AIO-KHT-0115)
Authors: V. Gruenwald, U. Graeven, P. Ivanyi, A. Dietz, D. Hahn, S. Hackenberg, S. Kasper, R. Fietkau, J-C. Moulin, D. Pink, M. Schaaf, K. Klinghammer
Journal: Annals of Oncology (2021)
Injectable Acylhydrazone‐Linked RAFT Polymer Hydrogels for Sustained Protein Release and Cell Encapsulation
Authors: Fang‐Yi Lin, Nathan H. Dimmitt, Mariana Moraes de Lima Perini, Jiliang Li, Chien‐Chi Lin
Journal: Advanced Healthcare Materials (2021)

A new class of temperature responsive polymer, termed PADO, is synthesized by reversible addition-fragmentation chain-transfer polymerization. Synthesized from copolymerization of diacetone acrylamide (DAAM), di(ethylene glycol) ethyl ether acrylate, and oligo(ethylene glycol) methyl ether acrylate, PADO polymer phase separates at temperature above its lower critical solution temperature (36-42 °C) due to enhanced hydrophobic interactions between the short ethylene glycol side chains. Solution of PADO polymers exhibit injectable shear-thinning properties and reach sol-gel transition rapidly (<5 min) at 37 °C. When the ketone moieties on DAAM are linked by adipic acid dihydrazdie, PADO polymers form crosslinked and injectable acylhydrazone hydrogels, which are hydrolytically degradable at a mild acidic environment owing to the pH sensitive acylhydrazone bonds. The pH-responsive degradation kinetics can be controlled by tuning polymer contents and ketone/hydrazide ratio. Importantly, the injectable PADO hydrogels are highly cytocompatible and can be easily formulated for pH-responsive sustained protein delivery.
1336P Anlotinib in elderly patients with advanced non-squamous non-small cell lung cancer (NSCLC) who had not received systemic chemotherapy: A single-arm, multi-center, phase II study
Authors: D. Zhao, X. Hou, Z. Li, L. Yang, X. Hou, H. Li, L. Yan, H. Liu, Z. Li, X. Liu, F. Song, G. Li, Y. Zhang
Journal: Annals of Oncology (2021)
769P Urinary microRNAs as biomarkers for early detection of ovarian cancer
Authors: S. Tate, K. Nishikimi, A. Matsuoka, S. Otsuka, K. Takayama, Y. Chen, H. Yamaguchi, T. Yasui, Y. Ichikawa, M. Shozu
Journal: Annals of Oncology (2021)
Image‐Guided TME‐Improving Nano‐Platform for Ca<sup>2+</sup> Signal Disturbance and Enhanced Tumor PDT (Adv. Healthcare Mater. 19/2021)
Authors: Yuping Jiang, Wei Meng, Lijuan Wu, Kai Shao, Lili Wang, Mengchao Ding, Jinsheng Shi, Xiaoying Kong
Journal: Advanced Healthcare Materials (2021)

Photodynamic Therapy In article number 2100789 by Jinsheng Shi, Xiaoying Kong, and co-workers, the combined strategy of UCRSPH and SA CaO2 nano platform strategy achieves the combined application of self reinforcing PDT, Ca2+ ion interference therapy and multi means in situ imaging in the diagnosis and treatment of tumors, which is of great significance for improving the clinical therapeutic effect of tumors for precise in tumor imaging and therapy in vivo.
963MO Naxitamab for the treatment of refractory/relapsed high-risk neuroblastoma (HR NB): Updated efficacy and safety data from the international, multicenter phase II trial 201
Authors: J. Mora, M. Bear, G. Chan, D.A. Morgenstern, K. Nysom, K. Tornøe, N. Losic, B. Kushner
Journal: Annals of Oncology (2021)
90P Longitudinal circulating tumor DNA profiling of metastatic urothelial carcinoma in the POLARIS-03 trial
Authors: H. Chen, R. Zhang, F. Xie, Y. Zhang, Y. Wang, A. Shahatiaili, J. Zang, P. Du, S. Jia, W. Xue, G. Zhuang, Y. Huang
Journal: Annals of Oncology (2021)
595P Correlation between genomic alterations and germline mutations in men with metastatic castration-resistant prostate cancer (mCRPC)
Authors: C. Llacer Perez, L. Oliva Fernandez, E. Cañada-Higueras, M.I. Sáez, R. Villatoro, A. Montesa Pino, B. Herrera Imbroda, D. Hernández, R. Lozano Mejorada, N. Romero Laorden, M. Marquez, G. Grau, A. Pineda, F.J. López, P. Peinado, D. Alameda, D. Olmos, E. Castro
Journal: Annals of Oncology (2021)
1746P Health-related quality-of-life (HRQoL) analyses from study 211: A phase 2 study in patients (pts) with radioiodine-refractory differentiated thyroid cancer (RR-DTC) treated with 2 starting doses of lenvatinib (LEN)
Authors: M.H. Taylor, S. Leboulleux, Y. Panaseykin, B. Konda, C. de la Fouchardiere, B.G.M. Hughes, A.G. Gianoukakis, Y.J. Park, I. Romanov, M.K. Krzyzanowska, D. Garbinsky, B. Sherif, J.J. Pan, T.A. Binder, N. Sauter, R. Xie, M.S. Brose
Journal: Annals of Oncology (2021)
1868P Real-world safety of the 6-weekly pembrolizumab regimen in cancer patients treated in South East London
Authors: M. Kapiris, L. Cain, M. Khan, C. Aversa, D. Josephs, K. Zaki, M. Harries, S. Papa, C. Nikolaou, D. Enting, S.M. Rudman, S. Ghosh, A. Montes, L. Karapanagiotou, J. Spicer, E. Pintus, A. Georgiou
Journal: Annals of Oncology (2021)
1160P Efficacy and biomarker identification of neoadjuvant chemo-immunotherapy in potentially resectable non-small cell lung cancer
Authors: Y. Zhang, L. Zeng, X. Zhang, Y. Zhou, B. Zhang, L. Guo, Y. Guan, X. Gao, H. Wang, X. Xia, C. Zhou, N. Yang
Journal: Annals of Oncology (2021)
Genome-Wide Analysis of Cadmium-Induced, Germline Mutations in a Long-Term <i>Daphnia pulex</i> Mutation-Accumulation Experiment
Authors: Nathan Keith, Craig E. Jackson, Stephen P. Glaholt, Kimberly Young, Michael Lynch, Joseph R. Shaw
Journal: Environmental Health Perspectives (2021)

Germline mutations provide the raw material for all evolutionary processes and contribute to the occurrence of spontaneous human diseases and disorders. Yet despite the daily interaction of humans and other organisms with an increasing number of chemicals that are potentially mutagenic, precise measurements of chemically induced changes to the genome-wide rate and spectrum of germline mutation are lacking.
The Alpha variant was not associated with excess nosocomial SARS-CoV-2 infection in a multi-centre UK hospital study
Authors: Florencia A.T. Boshier, Cristina Venturini, Oliver Stirrup, José Afonso Guerra-Assunção, Adela Alcolea-Medina, Angela H. Becket, Matthew Byott, Themoula Charalampous, Ana da Silva Filipe, Dan Frampton, Sharon Glaysher, Tabassum Khan, Raghavendran Kulasegara-Shylini, Beatrix Kele, Irene M. Monahan, Guy Mollett, Matthew Parker, Emanuela Pelosi, Paul Randell, Sunando Roy, Joshua F. Taylor, Sophie J. Weller, Eleri Wilson-Davies, Phillip Wade, Rachel Williams, Andrew J. Copas, Teresa Cutino-Moguel, Nick Freemantle, Andrew C. Hayward, Alison Holmes, Joseph Hughes, Tabitha W. Mahungu, Gaia Nebbia, Eleni Nastouli, David G. Partridge, Cassie F. Pope, James R. Price, Samuel C. Robson, Kordo Saeed, Gee Yen Shin, Thushan I. de Silva, Luke B. Snell, Emma C. Thomson, Adam A. Witney, Judith Breuer
Journal: Journal of Infection (2021)

ObjectivesRecently emerging SARS-CoV-2 variants have been associated with an increased rate of transmission within the community. We sought to determine whether this also resulted in increased transmission within hospitals.MethodsWe collected viral sequences and epidemiological data of patients with community and healthcare associated SARS-CoV-2 infections, sampled from 16th November 2020 to 10th January 2021, from nine hospitals participating in the COG-UK HOCI study. Outbreaks were identified using ward information, lineage and pairwise genetic differences between viral sequences.ResultsMixed effects logistic regression analysis of 4184 sequences showed healthcare-acquired infections were no more likely to be identified as the Alpha variant than community acquired infections. Nosocomial outbreaks were investigated based on overlapping ward stay and SARS-CoV-2 genome sequence similarity. There was no significant difference in the number of patients involved in outbreaks caused by the Alpha variant compared to outbreaks caused by other lineages.ConclusionsWe find no evidence to support it causing more nosocomial transmission than previous lineages. This suggests that the stringent infection prevention measures already in place in UK hospitals contained the spread of the Alpha variant as effectively as other less transmissible lineages, providing reassurance of their efficacy against emerging variants of concern.
LBA10 Nal-IRI with 5-fluorouracil (5-FU) and leucovorin or gemcitabine plus cisplatin in advanced biliary tract cancer: Final results of the NIFE-trial (AIO-YMO HEP-0315), a randomized phase II study of the AIO biliary tract cancer group
Authors: L. Perkhofer, J.K. Striefler, M. Sinn, B. Opitz, T.O. Goetze, E. Gallmeier, L. Fischer von Weikersthal, L. Jacobasch, D. Waldschmidt, M. Niedermeier, M. Sohm, D. Sookthai, A. Berger, A. Beutel, T. Seufferlein, T.J. Ettrich
Journal: Annals of Oncology (2021)
Gram-negative neonatal sepsis in low- and lower-middle-income countries and WHO empirical antibiotic recommendations: A systematic review and meta-analysis
Authors: Sophie C. H. Wen, Yukiko Ezure, Lauren Rolley, Geoff Spurling, Colleen L. Lau, Saba Riaz, David L. Paterson, Adam D. Irwin
Journal: PLoS Medicine (2021)

Background Neonatal sepsis is a significant global health issue associated with marked regional disparities in mortality. Antimicrobial resistance (AMR) is a growing concern in Gram-negative organisms, which increasingly predominate in neonatal sepsis, and existing WHO empirical antibiotic recommendations may no longer be appropriate. Previous systematic reviews have been limited to specific low- and middle-income countries. We therefore completed a systematic review and meta-analysis of available data from all low- and lower-middle-income countries (LLMICs) since 2010, with a focus on regional differences in Gram-negative infections and AMR. Methods and findings All studies published from 1 January 2010 to 21 April 2021 about microbiologically confirmed bloodstream infections or meningitis in neonates and AMR in LLMICs were assessed for eligibility. Small case series, studies with a small number of Gram-negative isolates (&lt;10), and studies with a majority of isolates prior to 2010 were excluded. Main outcomes were pooled proportions of Escherichia coli , Klebsiella , Enterobacter , Pseudomonas , Acinetobacter and AMR. We included 88 studies (4 cohort studies, 3 randomised controlled studies, and 81 cross-sectional studies) comprising 10,458 Gram-negative isolates from 19 LLMICs. No studies were identified outside of Africa and Asia. The estimated pooled proportion of neonatal sepsis caused by Gram-negative organisms was 60% (95% CI 55% to 65%). Klebsiella spp. was the most common, with a pooled proportion of 38% of Gram-negative sepsis (95% CI 33% to 43%). Regional differences were observed, with higher proportions of Acinetobacter spp. in Asia and Klebsiella spp. in Africa. Resistance to aminoglycosides and third-generation cephalosporins ranged from 42% to 69% and from 59% to 84%, respectively. Study limitations include significant heterogeneity among included studies, exclusion of upper-middle-income countries, and potential sampling bias, with the majority of studies from tertiary hospital settings, which may overestimate the burden caused by Gram-negative bacteria. Conclusions Gram-negative bacteria are an important cause of neonatal sepsis in LLMICs and are associated with significant rates of resistance to WHO-recommended first- and second-line empirical antibiotics. AMR surveillance should underpin region-specific empirical treatment recommendations. Meanwhile, a significant global commitment to accessible and effective antimicrobials for neonates is required.
736P Preliminary results of anlotinib and niraparib dual therapy evaluation in platinum-resistant recurrent ovarian cancer (ANNIE): A multicenter, single-arm, phase II trial
Authors: J. Liu, G. Liu, J. Li, Y. Feng, H. Huang, T. Wan, Q. Huang, B. Xian, B. Kong, A. Lin
Journal: Annals of Oncology (2021)
1468P POLO: Subsequent therapy after maintenance olaparib in patients with a germline BRCA mutation and metastatic pancreatic cancer
Authors: T. Golan, P. Hammel, M. Reni, E. Van Cutsem, T. Macarulla Mercade, M.J. Hall, J.O. Park, D. Hochhauser, D. Arnold, D-Y. Oh, A. Reinacher-Schick, G. Tortora, H. Algül, E.M. O'Reilly, S. Bordia, D. McGuinness, K.Y. Cui, G. Locker, H. Kindler
Journal: Annals of Oncology (2021)
Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas
Authors: Adem Y. Dawed, Sook Wah Yee, Kaixin Zhou, Nienke van Leeuwen, Yanfei Zhang, Moneeza K. Siddiqui, Amy Etheridge, Federico Innocenti, Fei Xu, Josephine H. Li, Joline W. Beulens, Amber A. van der Heijden, Roderick C. Slieker, Yu-Chuan Chang, Josep M. Mercader, Varinderpal Kaur, John S. Witte, Ming Ta Michael Lee, Yoichiro Kamatani, Yukihide Momozawa, Michiaki Kubo, Colin N.A. Palmer, Jose C. Florez, Monique M. Hedderson, Leen M. ‘t Hart, Kathleen M. Giacomini, Ewan R. Pearson, Ewan Pearson, Adem Dawed, Kaixin Zhou, Rury Holman, Ruth Coleman, Leen ‘t Hart, Roderick Slieker, Joline Beulens, Amber van der Heijden, Giel Nijpels, Petra Elders, Femke Rutters, Bruno Stricker, Fariba Ahmadizar, Catherine de Keyser, Adriaan Koov, Mattijs Out, Jānis Kloviņš, Linda Zaharenko, Martin Javorsky, Ivan Tkac, Jose Florez, Kathy Giacomini, Sook Wah Yee, Monique Hedderson, Michiaki Kubo, Alison Motsinger-Reif, Michael Wagner, Sabina Semiz, Tanja Dujic, Mette Christensen, Kim Brøsen, Dawn Waterworth, Meg Ehm, Ronald Ma, Bruce Psaty, James Floyd
Journal: Diabetes Care (2021)

Sulfonylureas, the first available drugs for the management of type 2 diabetes, remain widely prescribed today. However, there exists significant variability in glycemic response to treatment. We aimed to establish heritability of sulfonylurea response and identify genetic variants and interacting treatments associated with HbA
1784P Targeting FGFR signaling with FGFR inhibitor-based regimens: UCSD molecular tumor board experience
Authors: Y. Uehara, I. Sadakatsu, J.K. Sicklick, H. Persha, R. Jimenez, K.H. Kim, H.J. Lim, S. Lee, R. Okamura, S. Kato, R. Kurzrock
Journal: Annals of Oncology (2021)
Abstract 10591: Post-traumatic Stress Disorder, Metabolic Syndrome and Cardiovascular Mortality;the Role of Selective Serotonin Reuptake Inhibitor
Authors: Naser Ahmadi, Hormoz Babaei, Rachel Yehuda, David Garfield, Ramin Ebrahimi
Journal: Circulation (2012)

Background: Lifetime prevalence of combat post-traumatic stress disorder (PTSD) is 5% to 20% in the United States. We recently reported a significant relation of PTSD with subclinical and cardiovas...
1017P Preclinical evaluation of KD033, a human anti-PD-L1/IL-15 bispecific protein, in human PD-1/PD-L1 transgenic C57/Bl6 mice with PD-L1 positive and negative tumors
Authors: S. Martomo, D. Lu, Z. Polonskaya, X. Luna, Z. Zhang, G. Regev, O. Schueller, J. Patel
Journal: Annals of Oncology (2021)
关节痛-多发淋巴结肿大-发热-血小板减少
Authors: 孙芳芳, 沈敏
Journal: BMJ (2011)

患者男,57岁,因“关节痛1年,发热5个月,皮肤出血点1个月”于2011年2月12日入院.1年前患者无诱因出现全身多关节疼痛,主要累及肩、肘、腕、膝、踝度双手小关节,伴右踝关节肿胀,夜间为著,无晨僵.5个月前开始间断发热,最高体温38℃,多于夜间达峰,伴乏力、盗汗、纳差、消瘦,近1年体重下降11 kg,无畏寒、寒战、咳嗽.血常规:白细胞7 7×109/L,血红蛋白115 g/L,血小板189×109/L;肝功能:乳酸脱氢酶(LDH) 512 U/L,余正常;血肌酐201 μmol/L;C反应蛋白(CRP) 3.2 mg/L,血红细胞沉降率(血沉)115 mm/1 h;尿常规:尿蛋白(+),红细胞(±);肿瘤标志物(-);巨细胞病毒(CMV)抗体(-);胸部CT(图1):右肺中下叶炎性病变,右侧胸腔积液伴右肺下叶膨胀不全,纵隔淋巴结及双侧腋窝淋巴结增大.骨扫描(-).正电子发射断层显像(PET):全身多发淋巴结肿大,脾、双肾体积增大,淋巴结、鼻咽部软组织、肝、脾及双肾氟脱氧葡萄糖(FDG)代谢异常增高,标准摄取值(SUV)最高达11,符合恶性病变特征,考虑恶性淋巴瘤.外院针对“肺炎”予抗感染治疗无效。