tbuckley/cabot-search huggingface dataset:
DOUBTS CLEARING AWAY.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical News
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute respiratory distress syndrome. A presenting symptom of malignant lymphoma
Authors: M. Ravid
Journal: JAMA (1979)

POSTMORTEM evidence of pulmonary involvement was found in 40% of patients with malignant lymphoma.<sup>1</sup>During the course of the disease, approximately 7% of the patients showed hilar lymphadenopathy. Pulmonary parenchymal infiltration is rare.<sup>2</sup>A clinical syndrome directly related to pulmonary infiltration was described in a few single cases as a terminal event of a rapidly progressive disease.<sup>3</sup>In this report, we describe three patients in whom an acute respiratory distress syndrome was the presenting symptom of malignant lymphoma. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 72-year-old man had severe respiratory distress that had developed over the previous four days. On examination, there were tachypnea, cyanosis, and tachycardia, but no fever. Coarse crepitations and occasional rhonchi were audible over both lungs. There was no venous congestion, and the liver and the spleen were not enlarged. The left anterior cervical lymph nodes were enlarged. There was a necrotic area on
Traumatic intracranial hematomas. Role of CSF leakage
Authors: J. E. Woodford
Journal: JAMA (1974)

Three patients had posttraumatic cerebrospinal fluid leakage and each developed an intracranial hematoma. All were operated on after three to ten days of neurologic stability. Two were found to have extradural hematomas and one had a subdural hematoma. Our experience emphasizes the need for care in observing the patient with a head injury and a leakage of spinal fluid. Neurologic deterioration may occur even after a period of days.
In Reply
Authors: Pablo Mojica, David Smith, Joshua D.I. Ellenhorn
Journal: Journal of Clinical Oncology (2007)

and adjuvant radiation therapy, excluding those patients who died within 4 months of diagnosis. 2Adjuvant radiation therapy was not associated with a significant mortality hazard ratio (HR) in the Cox proportional hazard multivariate analysis.The mortality HR for radiation therapy was 0.83 (95% CI, 0.63 to 1.09). 2 The mortality HR for radiation therapy by MSKCC stage was: stage I HR, 1.01 (95% CI, 0.65 to 1.56), stage II HR, 0.82 (95% CI, 0.46 to 1.45), and stage III HR, 0.73 (95% CI, 0.46 to 1.15). 2 The analysis offered by Mojica et al is limited by selection bias.Once correcting for the selection bias, adjuvant radiation therapy does not significantly improve overall survival based on our independent analysis.SEER is an excellent resource, but because of the inability to access and evaluate potentially confounding data based on the limitations of the SEER registry (as mentioned by the authors), any definitive results related to therapeutic maneuvers must be considered with extraordinary caution.Variables such as chemotherapy use, margin status, radiation therapy dose, technical radiation therapy detail, comorbidities, and local control are not readily available from the SEER registry.These factors and those we described earlier, may have substantial influence over survival findings.Definitive therapeutic conclusions should be tempered by the lack of access to these potentially important pieces of information.
PARIS
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Surgical Aspects in Rehabilitation of Patients with Congenital Malformation Associated with Thalidomide
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nitrates in Heart Failure with Preserved Ejection Fraction
Journal: New England Journal of Medicine (2016)

isolates in this patient may have arisen from the spread of the resistance element within the host, from exposure to other KPE-colonized patients (since KPC-3 is the dominant carbapenemase in this hospital), or both.This report illustrates the limitations of conducting investigations of carbapenemase outbreaks with traditional epidemiologic and molecular tools.
SOME REMARKS ABOUT ASEPSIS IN MILITARY SERVICE.
Authors: EDWARD BOECKMANN
Journal: JAMA (1896)

Very recently something has been written about catgut, which can be boiled after treatment with formalin, a 40 per cent. solution of formol (formaldehyd), a tanning agent of pronounced antiseptic properties. Thereby nothing is accomplished. Formalin evaporates during the boiling; the catgut, which formalin has converted into a sort of absorbable wormgut, is sterilized like the last only on the surface. Those microörganisms, not destroyed during the hardening with formalin, whose germicidal power in a given time is very feeble, are liberated, as the catgut is absorbed, from the interior which is not affected by the boiling water. Consequently I do not hope much for formalized catgut which can be boiled. Tanned catgut, either formalized or chromicized, has, however, an apparent advantage in being absorbed slowly; I, for my part, do not see any reason for using any but the fat-containing, sterile catgut, which resists absorption sufficiently long. In order
Non-A, non-B hepatitis
Authors: S. M. Feinstone
Journal: JAMA (1978)

Sensitive serologic tests capable of diagnosing essentially all infections with hepatitis A virus and hepatitis B virus (HBV) have shown that certain patients with a viral hepatitis-like syndrome have neither hepatitis A nor hepatitis B. Such cases of non-A, non-B hepatitis have been most frequently recognized in studies of transfusion-associated hepatitis. Less than 20% of posttransfusion hepatitis is due to HBV if only blood from voluntary donors that has been screened by thirdgeneration tests for the presence of hepatitis B surface antigen is used for transfusion. Type A hepatitis rarely, if ever, results from blood transfusion.<sup>1,2</sup>Thus, most transfusion-associated hepatitis in the United States has an unknown cause. Non-A, non-B hepatitis resembles type B disease in several respects. First, the common route of infection by blood or blood products indicates that a chronic carrier state must exist in relatively asymptomatic persons. Second, non-A, non-B hepatitis has been found to
Comprehensive Neurotoxicity Assessment
Authors: Beverly M. Kulig
Journal: Environmental Health Perspectives (1996)

Significant progress has been made in recent years in terms of both the conceptualization of neurotoxicity assessment strategies as well as in the development of behavioral techniques for evaluating neurotoxic exposures.A tiered approach, for example, has been advocated as an assessment strategy in which testing would proceed in a stepwise fashion from general screening using simple behavioral methods and neuropathology (tier 1) to the characterization of effects (tier 2) using more specific testing techniques.With respect to tier-1 testing, behavioral observational methods have been standardized for screening purposes, and these technically simple techniques, together with automated methods for motor activity assessment, are being increasingly incorporated into chemical and drug safety evaluations for regulatory purposes.With respect to tier-2 testing, more technically sophisticated techniques and behavioral paradigms are available for characterizing the behavioral effects of chemical exposures on motor, sensory, and cognitive processes.Paradigms involving learned and unlearned behavior, for example, have been described for quantifying a variety of clinical signs of motor impairment including paretic gait disorders, tremor, and coordination deficits.Likewise, robust noninvasive behavioral methods capable of tracking changes in visual, auditory, and somatosensory thresholds during the course of exposure are also available.With respect to cognitive testing, numerous maze and operant techniques and paradigms measuring different aspects of performance, learning, and memory have been elaborated.This paper presents an overview of behavioral techniques currently used to assess neurotoxicity in adult laboratory animals and discusses their application to hazard identification and other areas of risk assessment.
Epidemiology, features and outcome of patients transplanted for hepatocellular carcinoma in the last decade: a single-center experience
Authors: Federica Invernizzi, Massimo Iavarone, Daniele Dondossola, Barbara Antonelli, Arianna Zefilippo, Tullia De Feo, Marco Maggioni, Angelo Sangiovanni, Pietro Lampertico, Giorgio Rossi, Maria Francesca Donato
Journal: Journal of Hepatology (2020)
Ferritin Levels and Their Association With Regional Brain Volumes in Tourette’s Syndrome
Authors: Daniel A. Gorman, Hongtu Zhu, George M. Anderson, Mark Davies, Bradley S. Peterson
Journal: American Journal of Psychiatry (2006)

Objective: A previous small study showed lower serum ferritin levels in subjects with Tourette’s syndrome than in healthy subjects. The authors measured peripheral iron indices in a large group of Tourette’s syndrome and comparison subjects and explored associations of ferritin levels with regional brain volumes. Method: Ferritin was measured in 107 children and adults (63 Tourette’s syndrome, 44 comparison); serum iron was measured in 73 (41 Tourette’s syndrome, 32 comparison). Magnetic resonance imaging scans were used to measure volumes of the basal ganglia and cortical gray matter. Results: Ferritin and serum iron were significantly lower in the Tourette’s syndrome subjects, although still within the normal range. No association was found between tic severity and either iron index. In the Tourette’s syndrome subjects, ferritin did not correlate significantly with caudate volume but did correlate positively with putamen volume. In the comparison subjects, ferritin correlated inversely with caudate volume but did not correlate significantly with putamen volume. Irrespective of diagnosis, ferritin correlated positively with volumes of the sensorimotor, midtemporal, and subgenual cortices. Conclusions: The lower peripheral ferritin and iron levels in persons with Tourette’s syndrome are consistent with findings in other movement disorders and suggest that lower iron availability may have a causal role in the pathophysiology of tic disorders. Lower iron stores may contribute to hypoplasia of the caudate and putamen, increasing vulnerability to developing tics or to having more severe tics. Lower iron stores may also contribute to smaller cortical volumes and consequently to reduced inhibitory control of tics.
Distribution of cholesterol between vesicles and micelles in human gallbladder bile: Influence of treatment with chenodeoxycholic acid and ursodeoxycholic acid
Authors: S Sahlin
Journal: Hepatology (1991)

The present study aimed at determining the relative distribution of cholesterol between the vesicular and micellar phases in gallbladder bile of gallstone patients (n = 23) and gallstone-free subjects (n = 7). Nine of the gallstone patients were treated with chenodeoxycholic acid and seven were treated with ursodeoxycholic acid, 15 mg/kg/day, for 3 wk before cholecystectomy. The vesicular and micellar fractions in bile were separated by sucrose density gradient ultracentrifugation, and a clear separation between the two phases was obtained. The vesicles were further identified by quasielastic light scattering spectroscopy and appeared to be of a uniform size with a mean hydrodynamic radius of 760 Å. The proportion of cholesterol in the vesicular fraction was significantly higher in the untreated gallstone group (40% ± 4%) compared with the gallstone-free (28% ± 3%), ursodeoxycholic acid (28% ± 3%) and chenodeoxycholic acid (18%± 4%) groups. Despite a low cholesterol saturation of bile in the latter three groups (88% ± 12%, 51% ± 9% and 65% ± 5%, respectively), a considerable part of the biliary cholesterol was carried in the vesicular fraction. The cholesterol/phospholipid ratio in the vesicular fraction averaged between 0.49 and 0.58 in the gallstone, gallstone-free and chenode-oxycholic acid groups, whereas the ursodeoxycholic acid group had a significantly lower ratio of 0.24. The cholesterol/phospholipid ratio was about 0.15 in all micellar fractions. The nucleation time of bile from the gallstone group was short (2 ± 1 days) compared with the gallstone-free, chenodeoxycholic acid and ursodeoxycholic acid groups (23 ± 3, 24 ± 6 and 14 ± 3 days, respectively). These observations give further support to the concept that the mechanism for gallstone dissolution is complex and different for chenodeoxycholic acid and ursodeoxycholic acid. (HEPATOLOGY 1991;13:104–110).
Comparative effectiveness of treatments for patellofemoral pain: a living systematic review with network meta-analysis
Authors: Marinus Winters, Sinéad Holden, Carolina Bryne Lura, Nicky J Welton, Deborah M Caldwell, Bill T Vicenzino, Adam Weir, Michael Skovdal Rathleff
Journal: British Journal of Sports Medicine (2020)

Objective To investigate the comparative effectiveness of all treatments for patellofemoral pain (PFP). Design Living systematic review with network meta-analysis (NMA). Data sources Sensitive search in seven databases, three grey literature resources and four trial registers. Eligibility criteria Randomised controlled trials evaluating any treatment for PFP with outcomes ‘any improvement’, and pain intensity. Data extraction Two reviewers independently extracted data and assessed risk of bias with Risk of Bias Tool V.2. We used Grading of Recommendations, Assessment, Development and Evaluation to appraise the strength of the evidence. Primary outcome measure ‘Any improvement’ measured with a Global Rating of Change Scale. Results Twenty-two trials (with forty-eight treatment arms) were included, of which approximately 10 (45%) were at high risk of bias for the primary outcome. Most comparisons had a low to very low strength of the evidence. All treatments were better than wait and see for any improvement at 3 months (education (OR 9.6, 95% credible interval (CrI): 2.2 to 48.8); exercise (OR 13.0, 95% CrI: 2.4 to 83.5); education+orthosis (OR 16.5, 95% CrI: 4.9 to 65.8); education+exercise+patellar taping/mobilisations (OR 25.2, 95% CrI: 5.7 to 130.3) and education+exercise+patellar taping/mobilisations+orthosis (OR 38.8, 95% CrI: 7.3 to 236.9)). Education+exercise+patellar taping/mobilisations, with (OR 4.0, 95% CrI: 1.5 to 11.8) or without orthosis (OR 2.6, 95% CrI: 1.7 to 4.2), were superior to education alone. At 12 months, education or education+any combination yielded similar improvement rates. Summary/conclusion Education combined with a physical treatment (exercise, orthoses or patellar taping/mobilisation) is most likely to be effective at 3 months. At 12 months, education appears comparable to education with a physical treatment. There was insufficient evidence to recommend a specific type of physical treatment over another. All treatments in our NMA were superior to wait and see at 3 months, and we recommend avoiding a wait-and-see approach. PROSPERO registeration number PROSPERO registration CRD42018079502.
FOOD AND DRINK.
Authors: ELMER LEE
Journal: JAMA (1900)

The larger part of the activities of man are spent in search of nutriment. In his diligence nothing escapes attention either in the animal or vegetable kingdom. A ceaseless and relentless hand is laid on almost every living or growing thing to provide material to appease and satisfy human appetite. Nothing great nor small, of either real or fancied value as nutriment, is missed by man, determined to have all there is to eat and drink. The animal cell has not changed in any particular during the period of its existence, and the requirements for growth and repair remain as ever the same. Even with the vast modifications since the advent of steam and electricity, primitive and simple limitations at this time govern a considerable proportion of the human family in its food-supply. There are whole races of men of sturdy and enduring structure subsisting on one or more natural
Descriptive epidemiology of primary brain and CNS tumors: Results from the Central Brain Tumor Registry of the United States, 1990-1994
Authors: T. S. Surawicz
Journal: Neuro-Oncology (1999)

The Central Brain Tumor Registry of the United States (CBTRUS) obtained 5 years of incidence data (1990-1994)-including reports on all primary brain and CNS tumors-from 11 collaborating state cancer registries.Data were available for 20,765 tumors located in the brain, meninges, and other CNS sites, including the pituitary and pineal glands.The average annual incidence was estimated at 11.5 cases per 100,000 person-years.The higher incidence of tumors in male patients (12.1 per 100,000 person-years) than in female patients (11.0 per 100,000 person-years) was statistically signi cant (P<0.05); the higher incidence in whites (11.6 per 100,000 person-years) compared with blacks (7.8 per 100,000 person-years) was statistically signi cant (P<0.05).The most frequently reported histologies were meningiomas (24.0%) and glioblastomas (22.6%).Higher rates for glioblastomas, anaplastic astrocytomas, oligoden-drogliomas, anaplastic oligodendrogliomas, ependymomas, mixed gliomas, astrocytomas not otherwise speci ed, medulloblastomas, lymphomas, and germ cell tumors in male than in female patients were statistically signi cant (P<0.05), with relative risks (RR) ranging from 1.3 to 3.4.Meningiomas were the only tumors with a signi cant excess in females (RR=0.5).We noted higher occurrence rates in whites than in blacks for the following histologies: diffuse astrocytomas, anaplastic astrocytomas, glioblastomas, oligodendrogliomas, ependymomas, mixed gliomas, astrocytomas NOS, medulloblastomas, nerve sheath tumors, hemangioblastomas, and germ cell tumors, with RRs ranging from 1.5 to 3.4.Racial differences in occurrence rates were not observed for predominately benign meningiomas or pituitary tumors.This study represents the largest compilation of data on primary brain and CNS tumors in the United States.Standard reporting de nitions and practices must be universally adopted to improve the quality and use of cancer registry data.
Paroxysmal Atrial Tachycardia with Block Around the Ectopic Pacemaker: Report of a Case
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal