tbuckley/cabot-search huggingface dataset:
Looking Back
Authors: Lauren Glick, Laura A. Fitzpatrick, Allan S. Detsky, Raphael P. Rush
Journal: New England Journal of Medicine (2022)

An 82-year-old woman presented to the emergency department with a 3-week history of severe low back pain, rigors, anorexia, difficulty ambulating, and a sensation of incomplete urination. She had no numbness, tingling, weakness, saddle anesthesia, or fecal incontinence.
THE SIZE, MANOEUVRABILITY, SITE, HISTORY SCORE (SMSH)—A NEW TOOL FOR PREDICTING THE OUTCOMES OF COLORECTAL ENDOSCOPIC SUBMUCOSAL DISSECTION
Authors: C. Juglard, T. Lambin, T. Wallenhorst, V. Lepilliez, M. Schaefer, T. Degand, S. Chaussade, G. Rahmi, Y. Le Baleur, R. Legros, J. Albouys, J. Rivory, J.B. Chevaux, S. Leblanc, F. Rostain, H. Lepetit, M. Dahan, M. Barret, R. Hallit, P. Lafeuille, G. Perrod, T. Ponchon, M. Pijoan Comas, J. Jacques
Journal: Endoscopy (2022)

Aims Despite its undeniable carcinologic advantages, endoscopic submucosal dissection (ESD) has not replaced piecemeal endoscopic mucosal resection in Western countries because of the technical difficulty, long procedure duration, high complication rate, and steep learning curve. Differentiation of easy and difficult lesions would promote use of ESD. The objective of this study was to try to create a score that predict outcomes after colorectal ESD for large superficial lesions.
SCORE REPRODUCIBILITY AND RELIABILITY IN DIFFERENTIATING SMALL BOWEL SUBEPITHELIAL MASSES FROM INNOCENT BULGES
Authors: M. Sciberras, K. Gatt, L. Elli, L. Scaramella, M.E. Riccioni, C. Marmo, S. Cadoni, M. McAlindon, R. Sidhu, F Ohara, D. McNamara, E. Rondonotti, S. Piccerelli, C. Spada, M. Bruno, M. Keuchel, P. Baltes, N. Calleja, R. Margalit, A Koulaouzidis, P Cortegoso Valdivia, G. de’Angelis, X. Dray, P. Ellul
Journal: Endoscopy (2022)

Aims To assess the reliability, intra- and inter-observer variation of the smooth of the smooth protruding lesions index at capsule endoscopy (SPICE), Mucosal protrusion angle (MPA) and SHYUNG scores in differentiating a subepithelial mass (SEM) from a bulge.
HYPERNEFROMA GASTRIC METASTASIS: RESECTION BY “LOOP-AND-LET-GO” TECHNIQUE
Authors: D. Vazquez Gomez, G. Torres Vicente, N. Zaragoza Velasco, L. Puñal Vidal, E. Pijoan Comas, M.I. Miguel Salas, M.N. Torres Monclús, D.C. Bayas Pástor, J.M. Reñé Espinet, F. Gonzalez-Huix Lladó
Journal: Endoscopy (2022)

A 63-year-old man with previous left partial nephrectomy due to hypernephroma in 2017. A CT scan in 2021 shows a polyp on gastric body. Gastroscopy revealed a 4 cm polypoid mass, friable, with a wide and short pedicle, on greater curvature.
CLINICAL OUTCOMES IN SEVERE OESOPHAGITIS
Authors: R. Grant, W. Brindle, E. Rycroft, O. Oyewole, S. Morgan, E. Watson, G. Masterton, R. Kalla
Journal: Endoscopy (2022)

Aims To determine if there are differences in clinical outcomes between those with LA grades C and grade D oesophagitis at index oesophago-gastro-duodenoscopy (OGD1).
THE YIELD OF BILIARY BRUSH CYTOLOGY IN BILIARY STRICTURES
Authors: C. Belkhayat, F. Amri, M.A. Kaddouri, O. El Mqaddem, Z. Tammouch, M. Oustani, A. Zazour, G. Kharrasse, Z. Ismaili, W. Khannoussi
Journal: Endoscopy (2022)

Aims The aim of this study is to assess the yield of biliary brush cytology into determining malignant causes of biliary stricture.
UNDERWATER TECHNIQUE IMPROVES DISSECTION SPEED IN COLORECTAL ENDOSCOPIC SUBMUCOSAL DISSECTION
Authors: P. Cecinato, M. Lucarini, F. Azzolini, F. Bassi, R. Sassatelli
Journal: Endoscopy (2022)

Aims Colorectal endoscopic submucosal dissection (ESD) is a technically difficult, time-consuming and sometimes risky procedure. Tissue traction and good submucosal exposure are important factors for an effective, safe dissection. Underwater ESD (U-ESD) consists in performing an ESD in water or saline immersion, this technique provides multiple advantages, is inexpensive and easy to perform. This study evaluated underwater ESD (U-ESD) as compared to conventional ESD (C-ESD) for dissection of superficial colorectal tumors.
TUNNELLING AND CLIP-WITH-LINE TECHNIQUES FOR SUCCESSFUL LONG CIRCUMFERENTIAL ESOPHAGEAL ESD
Authors: D. Falcão, J. Alves-Silva, S. Archer, I. Pedroto, R. Marcos-Pinto, R. Küttner-Magalhães
Journal: Endoscopy (2022)

A 67-year-old man was referred due to a circumferential 6cm, Paris 0-IIa, type V3 intrapapillary-capillary-loop classification lesion,from 37 to 43cm from the incisors, with biopsies revealing squamous cell carcinoma. Multiple minor Paris 0-IIb+0-IIc lesions were also observed proximally. Circumferential endoscopic submucosal dissection (ESD) was scheduled. Proximal and distal circumferential mucosal incisions were made. Two contralateral submucosal tunnels were accomplished, leaving two longitudinal lateral bridges.The additional use of clip-with-line technique allowed constant traction of the specimen enabling dissection of the remaining lateral bridges. A 15cm long specimen was retrieved.We demonstrated that combining tunnelling and clip-with-line techniques enables successful circumferential esophageal ESD.
WHICH TYPE OF SMALL-BOWEL CAPSULE ENDOSCOPY IS BETTER? A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: G. Blanco-Velasco, O.M. Solórzano-Pineda, L.F. García-Contreras, C. Martínez-Camacho, E. Murcio-Pérez, O.V. Hernández-Mondragón
Journal: Endoscopy (2022)

Aims Small-bowel capsule endoscopy (SBCE) is a safe and efficient method for the diagnosis of the pathologies of the small-bowel. Since the development of the SBCE in year 2000, different types of SBCE have been created. The aim of this study was to analyze which of the different types of SBCE has a better diagnostic yield.
A fully covered self-expandable metallic stent as a cystic-duct overtube facilitated stone removal from a gallbladder
Authors: Wiriyaporn Ridtitid, Natee Faknak, Krittaya Mekritthikrai, Rungsun Rerknimitr
Journal: Endoscopy (2022)

A 43-year-old woman who had undergone endoscopic cholangiopancreatography (ERCP) with plastic stenting for multiple gallstones and multiple liver cysts compressing the common bile duct (CBD) causing CBD stricture ([Fig. 1], [Fig. 2]) presented with recurrent cholangitis. Repeat ERCP revealed multiple CBD stones with resolution of the CBD stricture ([Fig. 3]). After complete removal of CBD stones, cholangiogram showed dilated cystic duct and a few stones left in a shrunken gallbladder. The patient agreed to endoscopic removal of the residual gallstones, and another ERCP was performed.
WERNICKE ENCEPHALOPATHY AFTER INTRAGASTRIC BALLOON PLACEMENT
Authors: J. Espinel, E. Pinedo
Journal: Endoscopy (2022)

Aims Intragastric balloon (IGB) therapy is a minimally invasive, temporary method of inducing weight loss. During the first week, most patients will develop nausea and vomiting. Wernicke encephalopathy (WE) is an acute syndrome characterized by the classic triad of ataxia, eye movement disorders, and mental status change. It occurs in the setting of poor nutrition, recurrent emesis, and other conditions related to Thiamine deficiency (vitamin B1). WE requires emergent treatment to prevent neurologic morbidity and death. The aim of this case report is to draw attention to the possible onset of Wernicke’s syndrome during IGB therapy.
68P 20-year tamoxifen benefit in ER-positive/HER2-negative breast cancer patients in randomized clinical trials
Authors: H.A. Dar, A. Johansson, A. Nordenskjöld, C. Yau, C. Benz, L. Essermann, K.A. Rodriguez-Wallberg, B.A. Nordenskjöld, G. Perez-Tenorio, O. Stal, T. Fornander, L. Lindström
Journal: Annals of Oncology (2022)
Ukraine: one in three people with chronic conditions have problems accessing healthcare
Authors: Melina Zachariou
Journal: BMJ (2022)

Ukraine: one in three people with chronic conditions have problems accessing healthcare Melina ZachariouTwo in five households remaining in Ukraine have at least one person with a chronic illness and a third of these are finding it difficult to access the care they need because of the ongoing war, a World Health Organization survey has found.Fewer than a third of the 1000 households that have so far responded to the needs assessment survey said that they have sought health services recently, mainly (39% of respondents) because of the security situation, although around a third (27%) said there were no healthcare services in their area.Jarno Habicht, WHO representative and head of the WHO country office in Ukraine, said that the findings show the urgent need for continued health systems support in Ukraine.Most households (70%) surveyed are sheltering in their own homes, while one in 10 (11%) are staying with friends and family members in relatively safer areas, 8% are on the move within Ukraine, and 3% are in a shelter or camp for internally displaced people.
Evaluation of Safety of Treatment With Anti–Epidermal Growth Factor Receptor Antibody Drug Conjugate MRG003 in Patients With Advanced Solid Tumors
Authors: Miao-Zhen Qiu, Yang Zhang, Ye Guo, Wei Guo, Weiqi Nian, Wangjun Liao, Zhongyuan Xu, Wenxue Zhang, Hong-Yun Zhao, Xiaoli Wei, Liqiong Xue, Wenbo Tang, Yunteng Wu, Guoxin Ren, Ling Wang, Jingle Xi, Yongshuai Jin, Hu Li, Chaohong Hu, Rui-Hua Xu
Journal: JAMA Oncology (2022)

The antibody drug conjugate drug MRG003 comprises an anti-epidermal growth factor receptor (EGFR) humanized immunoglobulin G1 monoclonal antibody that is conjugated with monomethyl auristatin E via a valine-citrulline linker. There is currently insufficient evidence of this drug's safety and efficacy.To evaluate the safety and maximum tolerated dose of MRG003 in a phase 1a study and investigate the preliminary antitumor activity in EGFR-expressing patients in a phase 1b study.This nonrandomized open-label, single-arm, phase 1, multicenter study of solid tumors was divided into 2 parts, phase 1a dose escalation and phase 1b dose expansion. Patients with advanced or metastatic solid tumors who had failed outcomes from or were not able to receive standard treatment were enrolled in phase 1a without EGFR prescreening. Phase 1b recruited EGFR-positive patients with refractory advanced squamous cell carcinomas of the head and neck (SCCHN), nasopharyngeal carcinoma (NPC), and colorectal cancer (CRC). This study was conducted at 7 Chinese centers between April 11, 2018, and March 29, 2021 (data cutoff date). Data analysis took place between April 2021 and June 2021.An intravenous dose of 0.1 to 2.5 mg/kg of MRG003 was administered every 3 weeks during phase 1a. During phase 1b, patients were administered the recommended dose identified in phase 1a.The primary end points were dose-limiting toxic effects in phase 1a and objective response rate in phase 1b. The safety, tolerability, immunogenicity, and pharmacokinetics of MRG003 were assessed. Tumor assessment was evaluated by RECIST 1.1.Twenty-two patients (mean [range] age, 54.5 [32.0-67.0] years; 9 women [41%]) were enrolled in phase 1a and 39 patients (mean [range] age, 50.4 [27.0-75.0] years; 8 women [21%]) in phase 1b. The recommended dose was identified as 2.5 mg/kg. Eighty-nine percent of adverse events (AEs) were associated with MRG003 treatment, and most AEs were grade 1 to 2. Nineteen patients (31%) reported grade 3 or greater treatment-related AEs, including hyponatremia, leukocytopenia, neutropenia, increased aspartate aminotransferase levels, and febrile neutropenia. In phase 1a, 1 patient (5%) achieved a partial response, and 5 (23%) achieved stable disease. In phase 1b, 8 patients (21%) achieved a confirmed partial response, and 12 (31%) achieved stable disease. The objective response rates for SCCHN, NPC, and CRC were 40%, 44%, and 0%, and the disease control rates were 100%, 89%, and 25%, respectively.The findings of this nonrandomized clinical trial suggest that MRG003 showed a manageable safety profile and promising antitumor activity in patients with EGFR-positive NPC and SCCHN.Clinicaltrials.gov Identifier: NCT04868344.
Efficacy and Safety of the RBD-Dimer–Based Covid-19 Vaccine ZF2001 in Adults
Authors: Lianpan Dai, Lidong Gao, Lifeng Tao, Sri R. Hadinegoro, Musabaev Erkin, Zhifang Ying, Peng He, Rodman T. Girsang, Hugo Vergara, Javed Akram, Hindra I. Satari, Tanwir Khaliq, Ume Sughra, Ana P. Celi, Fangjun Li, Yan Li, Zhiwei Jiang, Dilbar Dalimova, Jaloliddin Tuychiev, Shahlo Turdikulova, Aamer Ikram, Nancy Flores Lastra, Fan Ding, Mahendra Suhardono, Eddy Fadlyana, Jinghua Yan, Zhongyu Hu, Changgui Li, Ibrokhim Y. Abdurakhmonov, George F. Gao
Journal: New England Journal of Medicine (2022)

The ZF2001 vaccine, which contains a dimeric form of the receptor-binding domain of severe acute respiratory syndrome coronavirus 2 and aluminum hydroxide as an adjuvant, was shown to be safe, with an acceptable side-effect profile, and immunogenic in adults in phase 1 and 2 clinical trials.
ENDOSCOPIC SUBMUCOSAL DISSECTION IN THE DUODENUM – RESULTS OF THE GERMAN ESD REGISTRY
Authors: C. Fleischmann, A. Probst, A. Ebigbo, J. Schirra, J. Albert, S. Faiss, I. Wallstabe, R. Reinehr, H. Messmann
Journal: Endoscopy (2022)

Aims In Europe, endoscopic submucosal dissection (ESD) is not yet the standard treatment for premalignant or early malignant lesions in the gastrointestinal (GI)-tract. High quality data is mostly limited to single center studies, especially when it comes to duodenal ESD. In this study, we present results of the German ESD registry.
Zbtb20 identifies and controls a thymus-derived population of regulatory T cells that play a role in intestinal homeostasis
Authors: Agata K. Krzyzanowska, Rashade A. H. Haynes II, Damian Kovalovsky, Hsin-Ching Lin, Louis Osorio, Karen L. Edelblum, Lynn M. Corcoran, Arnold B. Rabson, Lisa K. Denzin, Derek B. Sant’Angelo
Journal: Science Immunology (2022)

The expression of BTB-ZF transcription factors such as ThPOK in CD4 + T cells, Bcl6 in T follicular helper cells, and PLZF in natural killer T cells defines the fundamental nature and characteristics of these cells. Screening for lineage-defining BTB-ZF genes led to the discovery of a subset of T cells that expressed Zbtb20. About half of Zbtb20 + T cells expressed FoxP3, the lineage-defining transcription factor for regulatory T cells (T regs ). Zbtb20 + T regs were phenotypically and genetically distinct from the larger conventional T reg population. Zbtb20 + T regs constitutively expressed mRNA for interleukin-10 and produced high levels of the cytokine upon primary activation. Zbtb20 + T regs were enriched in the intestine and specifically expanded when inflammation was induced by the use of dextran sodium sulfate. Conditional deletion of Zbtb20 in T cells resulted in a loss of intestinal epithelial barrier integrity. Consequently, knockout (KO) mice were acutely sensitive to colitis and often died because of the disease. Adoptive transfer of Zbtb20 + T regs protected the Zbtb20 conditional KO mice from severe colitis and death, whereas non-Zbtb20 T regs did not. Zbtb20 was detected in CD24 hi double-positive and CD62L lo CD4 single-positive thymocytes, suggesting that expression of the transcription factor and the phenotype of these cells were induced during thymic development. However, Zbtb20 expression was not induced in “conventional” T regs by activation in vitro or in vivo. Thus, Zbtb20 expression identified and controlled the function of a distinct subset of T regs that are involved in intestinal homeostasis.
BALLOON EXPANDABLE BIODEGRADABLE STENT USING EUS-ANTEGRADE APPROACH IN PATIENTS WITH BENIGN BILIARY STRICTURE AND SURGICALLY ALTERED ANATOMY
Authors: C. Robles-Medranda, R.C. Merfea, J. Alcivar-Vasquez, R. Del-Valle, M. Arevalo-Mora, J. Barreto-Perez
Journal: Endoscopy (2022)

Aims: Therapy of benign biliary strictures due to altered anatomy may be challenging. We report the first two cases of biodegradable metallic stent placement through EUS-HGS (endoscopic-ultrasound-hepaticogastrostomy)
THE ECONOMIC IMPACT OF THE REDUCTION IN THE NUMBER OF COLONOSCOPIES PERFORMED IN BRAZIL DURING THE COVID-19 PANDEMIC
Authors: T. Correa
Journal: Endoscopy (2022)

Aims During the COVID-19 pandemic, health systems can become overwhelmed and the lack of resources is a special concern in low- and middle-income countries. The number of colonoscopies performed may be reduced by the health system oversaturation and its financial resources can be redistributed to other areas. The aim of this study was to evaluate the number of colonoscopies performed in Brazil during the COVID-19 pandemic and its economic impact.
ARTIFICIAL INTELLIGENCE FOR LEAVING-IN-SITU COLORECTAL POLYPS: RESULTS OF A REAL-TIME CLINICAL TRIAL
Authors: C. Hassan, G. Balsamo, R. Lorenzetti, A. Zullo, G. Antonelli
Journal: Endoscopy (2022)

Aims Artificial Intelligence (AI) enables cost-saving strategies for screening colonoscopy using optical diagnosis, even in white-light endoscopy (WLE) with no need of advanced imaging. However, AI must match predefined criteria in order to be implemented in clinical setting.
Emerging experience with selected new categories in the <scp>ICD</scp>‐11: complex <scp>PTSD</scp>, prolonged grief disorder, gaming disorder, and compulsive sexual behaviour disorder
Authors: Geoffrey M. Reed, Michael B. First, Joël Billieux, Marylene Cloitre, Peer Briken, Sophia Achab, Chris R. Brewin, Daniel L. King, Shane W. Kraus, Richard A. Bryant
Journal: World Psychiatry (2022)

Among the important changes in the ICD-11 is the addition of 21 new mental disorders. New categories are typically proposed to: a) improve the usefulness of morbidity statistics; b) facilitate recognition of a clinically important but poorly classified mental disorder in order to provide appropriate management; and c) stimulate research into more effective treatments. Given the major implications for the field and for World Health Organization (WHO) member states, it is important to examine the impact of these new categories during the early phase of the ICD-11 implementation. This paper focuses on four disorders: complex post-traumatic stress disorder, prolonged grief disorder, gaming disorder, and compulsive sexual behaviour disorder. These categories were selected because they have been the focus of considerable activity and/or controversy and because their inclusion in the ICD-11 represents a different decision than was made for the DSM-5. The lead authors invited experts on each of these disorders to provide insight into why it was considered important to add it to the ICD-11, implications for care of not having that diagnostic category, important controversies about adding the disorder, and a review of the evidence generated and other developments related to the category since the WHO signaled its intention to include it in the ICD-11. Each of the four diagnostic categories appears to describe a population with clinically important and distinctive features that had previously gone unrecognized as well as specific treatment needs that would otherwise likely go unmet. The introduction of these categories in the ICD-11 has been followed by a substantial expansion of research in each area, which has generally supported their validity and utility, and by a significant increase in the availability of appropriate services.
ACCURACY AND SAFETY OF LOWER GI EUS-GUIDED FNA/FNB: A RETROSPECTIVE SINGLE-CENTER STUDY
Authors: M. Galanopoulos, K. Balendran, A. Paterson, S. Varghese, N. Carroll, E. Godfrey
Journal: Endoscopy (2022)

Aims The aim was to analyze the performance characteristics and safety of EUS-guided fine-needle aspiration/fine needle biopsy (FNA/FNB) via the lower GI tract.
94P Patient quality of life (QoL) from the GeparX trial on the addition of denosumab (Dmab) added to two different nab-paclitaxel (nP) regimens as neoadjuvant chemotherapy (NACT) in primary breast cancer (BC)
Authors: M. Reinisch, J-U. Blohmer, T. Link, M. Just, M. Untch, O. Stötzer, P.A. Fasching, A. Schneeweiss, P. Wimberger, S. Seiler, J. Huober, M. Thill, C. Jackisch, K. Rhiem, C. Solbach, C. Hanusch, C. Denkert, K. Engels, V. Nekljudova, S. Loibl
Journal: Annals of Oncology (2022)
18P Comparative genomic profiling of primary and locally recurrent luminal breast cancers (BC)
Authors: E. Rassy, I.J. Garberis, A. Tran Dien, V. Scott, I. Bouakka, J.J. Bassil, M. Lacroix-Triki, F. Zanconati, F. Giudici, D. Generali, E. Rouleau, L. Lacroix, F. André, B. Pistilli
Journal: Annals of Oncology (2022)
95P PAM50 HER2-enriched phenotype as a predictor of early response to neoadjuvant lapatinib plus trastuzumab HER2-positive breast cancer: Survival results of the SOLTI-PAMELA study
Authors: T. Pascual, B. Bermejo De Las Heras, N. Martinez, M. Oliveira, S. Pernas Simon, R. Lopez Lopez, I. Ruiz Cabrero, J.D. Alarcon, E. Martinez De Dueñas, D. Malon Gimenez, M. Gonzalez Cao, L.M. Manso Sanchez, S. Morales Murillo, H. Lopez de Ceballos, J. Cortés, A. Llombart Cussac, A. Prat
Journal: Annals of Oncology (2022)
How Protein Methylation Regulates Steroid Receptor Function
Authors: Lucie Malbeteau, Ha Thuy Pham, Louisane Eve, Michael R Stallcup, Coralie Poulard, Muriel Le Romancer
Journal: Endocrine Reviews (2021)

Abstract Steroid receptors (SRs) are members of the nuclear hormonal receptor family, many of which are transcription factors regulated by ligand binding. SRs regulate various human physiological functions essential for maintenance of vital biological pathways, including development, reproduction, and metabolic homeostasis. In addition, aberrant expression of SRs or dysregulation of their signaling has been observed in a wide variety of pathologies. SR activity is tightly and finely controlled by post-translational modifications (PTMs) targeting the receptors and/or their coregulators. Whereas major attention has been focused on phosphorylation, growing evidence shows that methylation is also an important regulator of SRs. Interestingly, the protein methyltransferases depositing methyl marks are involved in many functions, from development to adult life. They have also been associated with pathologies such as inflammation, as well as cardiovascular and neuronal disorders, and cancer. This article provides an overview of SR methylation/demethylation events, along with their functional effects and biological consequences. An in-depth understanding of the landscape of these methylation events could provide new information on SR regulation in physiology, as well as promising perspectives for the development of new therapeutic strategies, illustrated by the specific inhibitors of protein methyltransferases that are currently available.
A prospective pilot study of narrowband UV-B treatment of lichen planopilaris
Authors: James T. Pathoulas, Kelly E. Flanagan, Mack Y. Su, Sarina B. Elmariah, Yao Zhan, Chloe J. Walker, Laura J. Burns, Athena Manatis-Lornell, Lauren Penzi, Daniel D. Miller, Maria K. Hordinsky, Maryanne M. Senna
Journal: Journal of the American Academy of Dermatology (2022)
ELIAKIM AND CECDAIIC SCORES ARE USEFUL PAN-INTESTINAL TOOLS FOR CROHN’S DISEASE DIAGNOSIS AND ACTIVITY MONITORING
Authors: M. Freitas, T. Capela, V. Macedo Silva, C. Arieira, S. Xavier, T. Cúrdia Gonçalves, P. Boal Carvalho, F. Dias de Castro, B. Rosa, M. João Moreira, J. Cotter
Journal: Endoscopy (2022)

Aims Capsule endoscopy is a valuable tool in the diagnosis and monitoring of Crohn’s disease (CD). Recently, a new panenteric capsule (pan-CE), PillCam Crohn’s (Medtronic, USA) was approved. A novel quantitative score of inflammation for PillCam Crohn’s, the Eliakim score, has emerged. However, the optimal index for panenteric monitoring disease activity is far from being completely defined. We aimed to evaluate the correlation and accuracy between the pan-CE Eliakim and capsule endoscopy Crohn’s disease activity index (CECDAIic) scores and inflammatory parameters.
COMPARISON OF ENDOSCOPIC HEALING, HISTOLOGIC HEALING AND INTESTINAL BARRIER HEALING FOR PREDICTING LONG TERM DISEASE BEHAVIOUR IN IBD PATIENTS
Authors: T. Rath, R. Atreya, J. Bodenschatz, W. Uter, F. Vitali, S. Fischer, M. Waldner, A. Hartmann, M.F. Neurath
Journal: Endoscopy (2022)

Aims Endocopic healing is a key therapeutic goal in the management of inflammatory bowel diseases (IBD) that is associated with favorable disease outcome. Here, we prospectively compared the predictive value of endoscopic healing with histologic and barrier healing for predicting long-term disease behavior in a large cohort of clinical remittent IBD patients