tbuckley/cabot-search huggingface dataset:
Characteristics of glioblastoma long-term survivors
Authors: Tamara Ali, Farouk Olubajo, Nitika Rathi, Piyali Pal, Michael Jenkinson, Andrew Brodbelt
Journal: Neuro-Oncology (2021)

Abstract Aims Glioblastoma (GBM) is the commonest and most aggressive primary malignant brain tumour in adults. A small number of patients survive for &amp;gt;5 years and are referred to as long-term survivors (LTS). This study aimed to quantify and characterise GBM LTS in a single large UK centre. Method A retrospective observational cohort study was performed. Patients diagnosed with GBM in a single UK centre between 2000–2011 (inclusive) who survived &amp;gt;5 years from diagnosis were included. Histopathological samples were re-examined as per the WHO 2016 classification criteria and tested for molecular biomarkers including MGMT promoter methylation, IDH1/2 mutations, 1p19q codeletion and ATRX. Demographic, imaging, treatment and outcome data were collected. Results 1130 patients diagnosed with GBM were identified, 30 of whom survived for &amp;gt;5 years. Twenty-three were re-confirmed as GBM histologically and seven were reclassified as anaplastic oligodendroglioma or anaplastic astroctyoma. Median overall survival for this cohort was 6.2 years. We report a 2% 5-year survival, and a 0.7% 7-year survival. LTS-associated factors were younger age (&amp;lt;65 years old), frontal unilateral tumours, maximal management (surgery and chemoradiotherapy), good post-operative performance status (WHO &amp;lt;2), MGMT promoter methylation and IDH1/2 mutation. Conclusion A small subset of GBM patients survive for &amp;gt;5 years. Most still succumb to the disease, implying 5-year survival is not indicative of a cure. On applying current molecular markers, a quarter of previously diagnosed glioblastoma in this LTS population were revised to be WHO grade III gliomas.
Bowel Preparation for Colorectal Surgery
Authors: Olle Ljungqvist, Dileep N. Lobo
Journal: JAMA Surgery (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
EGR1 promotes androgen-independent growth and prothrombotic state in prostate cancer
Authors: Shan-Zhong Yang, Isam-Eldin Eltoum, Sarki A Abdulkadir
Journal: Cancer Research (2005)

976  During hormone therapy for prostate cancer, a major clinical problem is the development of androgen-independent prostate cancer. The molecular mechanisms underlying the transition from androgen dependence to independence are poorly understood and represent a major therapeutic challenge. Our previous study shows that Early Growth Response Gene (EGR1), which plays an oncogenic role in prostate cancer, binds to the androgen receptor (AR) in prostate carcinoma cells, and modulates AR signaling. In the present study, we further examined the effects of EGR1 on the growth of LNCaP androgen-dependent prostate cancer cells. EGR1 overexpression confers on hormone-sensitive LNCaP cells the ability to grow in low androgen concentrations, while EGR1 knockdown inhibits their growth. LNCaP-EGR1 cells were also resistant to androgen antagonists. These results were confirmed in vivo. In intact mice, there was no significant difference in tumor incidence between LNCaP-Neo and LNCaP-EGR1 cells; however, EGR1 overexpression significantly promoted tumor formation of LNCaP cells in castrated animals. These finding indicate that EGR1 plays a critical role in the transition from androgen-dependence to androgen-independence of prostate cancer by modulating androgen signaling. In addition, we found that there were obvious thrombosis, hemorrhage and fibrin deposition in EGR1 xenografts. EGR1 overexpression increased the expression of some angiogenesis and inflammation factors in LNCaP cells, including fibroblast growth factor 2 (FGF2), transforming growth factor beta 1 (TGF-beta1), IL-2 and endomucin. EGR1 xenografts also showed higher mRNA levels of mouse chemokines and procoagulatants, such as IL-8, macrophage chemotatic protein 2 (MCP2), tissue factor (TF), and plasminogen activator inhibitor 1(PAI-1), indicating that EGR1 may contribute to prothrombotic state in prostate cancer through the interaction of tumor cells with host cells. These results may also help to explain the well-known association between prostate carcinoma and thrombosis.
Corrigendum to ‘Detection of SARS-CoV-2 N-antigen in blood during acute COVID-19 provides a sensitive new marker and new testing alternatives’ [Clinical Microbiology and Infection 27/5 (2021) 789–790]
Authors: Le Hingrat, Quentin, Visseaux, Benoit, Laouenan, Cédric, Tubiana, Sarah, Bouadma, Lila, Yazdanpanah, Yazdan, Duval, Xavier, Burdet, Charles, Ichou, Houria, Damond, Florence, Bertine, Mélanie, Benmalek, Nabil, Choquet, Christophe, Timsit, Jean-François, Ghosn, Jade, Charpentier, Charlotte, Descamps, Diane, Houhou-Fidouh, Nadhira
Journal: Clinical Microbiology and Infection (2021)
Peroxidase from foxtail millet bran exerts anti-colorectal cancer activity via targeting cell-surface GRP78 to inactivate STAT3 pathway
Authors: Shuhua Shan, Jinping Niu, Ruopeng Yin, Jiangying Shi, Lizhen Zhang, Caihong Wu, Hanqing Li, Zhuoyu Li
Journal: Acta Pharmaceutica Sinica B (2021)

Molecular targeted therapy has become an emerging promising strategy in cancer treatment, and screening the agents targeting at cancer cell specific targets is very desirable for cancer treatment. Our previous study firstly found that a secretory peroxidase of class III derived from foxtail millet bran (FMBP) exhibited excellent targeting anti-colorectal cancer (CRC) activity in vivo and in vitro, whereas its underlying target remains unclear. The highlight of present study focuses on the finding that cell surface glucose-regulated protein 78 (csGRP78) abnormally located on CRC is positively correlated with the anti-CRC effects of FMBP, indicating it serves as a potential target of FMBP against CRC. Further, we demonstrated that the combination of FMBP with the nucleotide binding domain (NBD) of csGRP78 interfered with the downstream activation of signal transducer and activator of transcription 3 (STAT3) in CRC cells, thus promoting the intracellular accumulation of reactive oxygen species (ROS) and cell grown inhibition. These phenomena were further confirmed in nude mice tumor model. Collectively, our study highlights csGRP78 acts as an underlying target of FMBP against CRC, uncovering the clinical potential of FMBP as a targeted agent for CRC in the future.
P22.03 Role of Circulating Tumor Cell Subpopulations in Operable Non-Small Cell Lung Cancer Diagnosis and Prognosis
Authors: E. Fina, D. Federico, P. Novellis, E. Dieci, S. Monterisi, F. Cioffi, G. Mangiameli, G. Finocchiaro, M. Alloisio, G. Veronesi
Journal: Journal of Thoracic Oncology (2021)
Economic Incentives for Administrative Simplification
Authors: Bob Kocher, Anuraag Chigurupati
Journal: JAMA (2021)

Economic Incentives for Administrative SimplificationAdministrative complexity in the US health system has been identified as the source of enormous spending and potential cost savings. 1In a new report, Sahni and colleagues 2 provided a detailed evaluation of administrative cost-savings opportunities, including an estimated $175 billion that could be addressed without new laws or regulatory changes.Health care is complicated because complexity is profitable.In the US health care system, payers, health systems, physicians, other clinicians, drug companies, pharmacies, and pharmacy benefit managers all earn more revenue because of administrative complexity.Moreover, unlike virtually any other sector of the economy, except higher education, health care can raise prices annually faster than inflation. 3This means that revenues, margins, and profits can all improve without addressing administrative efficiency.In most other sectors, organizations can only improve margins if they improve labor productivity or simplify administration. 4hat administrative spending is greater in health care than other service industries is not new.Of the $3.8 trillion spent in 2019, an estimated $935 billion was on administrative spending. 1This percentage, approximately 25%, has been roughly constant for more than a decade. 5This Viewpoint explores the misaligned incentives that have made it difficult to make progress in reducing administrative spending and suggests potential changes necessary for administrative simplification to occur.
P52.02 High SHP2 Expression Determines the Efficacy of PD-1/PD-L1 Inhibitors in Advanced KRAS Mutant Non-Small Cell Lung Cancer
Authors: H. Feng, Y. Chen, Z. Xie, J. Jiang, Y. Zhong, L. Gao, W. Zhou, W. Guo, W. Yan, Z. Lv, D. Lu, H. Liang, F. Xu, J. Yang, X. Yang, Q. Zhou, D. Zhang, Z. Zhang, S. Chuai, H. Zhang, Y. Wu, X. Zhang
Journal: Journal of Thoracic Oncology (2021)
タンパク質代謝産物仮説、腎不全の進行のモデル:非透析された尿毒症性患者でインドキシル硫酸レベルを低下させる経口吸着剤
Authors: Niwa T, Nomura T, Sugiyama S, Miyazaki T, Tsukushi S, Tsutsui S
Journal: Kidney International (1997)
Electrostatic Flocking of Insulative and Biodegradable Polymer Microfibers for Biomedical Applications (Adv. Healthcare Mater. 19/2021)
Authors: Alec McCarthy, Johnson V. John, Lorenzo Saldana, Hongjun Wang, Matthew Lagerstrom, Shixuan Chen, Yajuan Su, Mitchell Kuss, Bin Duan, Mark A. Carlson, Jingwei Xie
Journal: Advanced Healthcare Materials (2021)

Flock Fibers In article number 2100766 by Jingwei Xie and co-workers, a new technique for electrostatic flocking is used to create anisotropic structures and surfaces for regenerative medicine applications. Using this method, electrospun nanofiber mats, 3D-printed meshes, and nanofiber tubes are surface-coated with flock fibers. Such materials are evaluated in vitro and in vivo and show promise as tissue engineering scaffolds.
Balint groups can support and invigorate GPs
Authors: Caroline M Spencer-Palmer
Journal: BMJ (2021)

I write in response to Helen Salisbury’s pertinent and timely column in which she states that few GPs have the time or energy for the Balint groups that once fulfilled the debriefing function in general practice.1

While it is true that only a minority of GPs attend Balint groups, the Balint Society is still growing, …
Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives
Authors: Xiaoqi Mao, Jin Xu, Wei Wang, Chen Liang, Jie Hua, Jiang Liu, Bo Zhang, Qingcai Meng, Xianjun Yu, Si Shi
Journal: Molecular Cancer (2021)

Abstract Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin, phenotypic and functional heterogeneity, are the most essential components of the tumor microenvironment (TME). Through multiple pathways, activated CAFs can promote tumor growth, angiogenesis, invasion and metastasis, along with extracellular matrix (ECM) remodeling and even chemoresistance. Numerous previous studies have confirmed the critical role of the interaction between CAFs and tumor cells in tumorigenesis and development. However, recently, the mutual effects of CAFs and the tumor immune microenvironment (TIME) have been identified as another key factor in promoting tumor progression. The TIME mainly consists of distinct immune cell populations in tumor islets and is highly associated with the antitumor immunological state in the TME. CAFs interact with tumor-infiltrating immune cells as well as other immune components within the TIME via the secretion of various cytokines, growth factors, chemokines, exosomes and other effector molecules, consequently shaping an immunosuppressive TME that enables cancer cells to evade surveillance of the immune system. In-depth studies of CAFs and immune microenvironment interactions, particularly the complicated mechanisms connecting CAFs with immune cells, might provide novel strategies for subsequent targeted immunotherapies. Herein, we shed light on recent advances regarding the direct and indirect crosstalk between CAFs and infiltrating immune cells and further summarize the possible immunoinhibitory mechanisms induced by CAFs in the TME. In addition, we present current related CAF-targeting immunotherapies and briefly describe some future perspectives on CAF research in the end.
MA16.03 CRISPR Screen Reveals XPO1 as a Therapeutic Target Strongly Sensitizing to First and Second Line Therapy in Small Cell Lung Cancer
Authors: A. Quintanal-Villalonga, H. Taniguchi, Y. Hao, A. Chow, Y. Zhan, S. Chavan, F. Uddin, V. Allaj, P. Manoj, N. Shah, J. Chan, M. Offin, J. Egger, U. Bhanot, J. Qiu, E. De Stanchina, T. Sen, J.t. Poirier, C. Rudin
Journal: Journal of Thoracic Oncology (2021)
A 10-year retrospective cohort study of ruxolitinib and association with nonmelanoma skin cancer in patients with polycythemia vera and myelofibrosis
Authors: John Q. Lin, Shirley Q. Li, Shufeng Li, Eileen F. Kiamanesh, Sumaira Z. Aasi, Bernice Y. Kwong, Anne Lynn Su Chang
Journal: Journal of the American Academy of Dermatology (2021)
Immunovascular classification of HCC reflects reciprocal interaction between immune and angiogenic tumor microenvironments
Authors: Yutaka Kurebayashi, Kosuke Matsuda, Akihisa Ueno, Hanako Tsujikawa, Ken Yamazaki, Yohei Masugi, Wit Thun Kwa, Kathryn Effendi, Yasushi Hasegawa, Hiroshi Yagi, Yuta Abe, Minoru Kitago, Hidenori Ojima, Michiie Sakamoto
Journal: Hepatology (2021)

Immune cells and tumor vessels constitute important elements in tumor tissue; however, their detailed relationship in human tumors, including HCC, is still largely unknown. Consequently, we expanded our previous study on the immune microenvironment of HCC and analyzed the relationship among the immune microenvironment, inflammatory/angiostatic factor expression, angiogenic factor expression, and tumor vessel findings, including vessels encapsulating tumor clusters (VETC) and macrotrabecular-massive (MTM) patterns.We classified HCC into four distinct immunovascular subtypes (immune-high/angiostatic [IH/AS], immune-mid/angio-mid [IM/AM], immune-low/angiogenic [IL/AG], and immune-low/angio-low [IL/AL]). IH/AS, IM/AM, and IL/AG subtypes were associated with decreasing lymphocytic infiltration and increasing angiogenic factor expression and VETC/MTM positivity, reflecting their reciprocal interaction in the tumor microenvironment of HCC. IL/AG subtype was further characterized by CTNNB1 mutation and activation of Wnt/β-catenin pathway. IL/AL subtype was not associated with increased lymphocyte infiltration or angiogenic factor expression. Prognostically, IH/AS subtype and VETC/MTM positivity were independently significant in two independent cohorts. Increased angiogenic factor expression was not necessarily associated with VETC/MTM positivity and poor prognosis, especially when inflammatory/angiostatic milieu coexisted around tumor vessels. These results may provide insights on the therapeutic effects of immunotherapy, antiangiogenic therapies, and their combinations. The potential of evaluating the immunovascular microenvironment in predicting the clinical effect of these therapies in nonresectable HCC needs to be analyzed in the future study.HCC can be classified into four distinct immunovascular subtypes (IH/AS, IM/AM, IL/AG, and IL/AL) that reflect the reciprocal interaction between the antitumor immune microenvironment and tumor angiogenesis. In addition to its clinicopathological significance, immunovascular classification may also provide pathological insights on the therapeutic effect of immunotherapy, antiangiogenic therapy, and their combination.
P62.01 PREVALUNG: Evaluation of Lung Cancer Prevalence in Patients With Smocking-associated Atherosclerotic Cardiovascular Diseases
Authors: D. Boulate, J. Issard, C. Caramella, P. Pradere, M. Fidelle, O. Hache, J. Pignon, B. Besse, L. Zitvogel, O. Mercier
Journal: Journal of Thoracic Oncology (2021)
FP05.03 Multiomic, Plasma-Only ctDNA NGS Assay Developed for Minimal Residual Disease (MRD) Detection in Early-Stage NSCLC
Authors: J. Kurata, K. Price, K. Banks, E. Zotenko, T. Dinman, P. Parsana, Z. Miao, J. Ju, D. Hite, D. Cheng, A. Talasaz
Journal: Journal of Thoracic Oncology (2021)
Automatic oxygen titration versus constant oxygen flow rates during walking in COPD: a randomised controlled, double-blind, crossover trial
Authors: Tessa Schneeberger, Inga Jarosch, Daniela Leitl, Rainer Gloeckl, Wolfgang Hitzl, Clancy John Dennis, Tatjana Geyer, Carl-Peter Criée, Andreas Rembert Koczulla, Klaus Kenn
Journal: Thorax (2021)

In patients with COPD, oxygen (O
Abstract 1872: New Fusion Technique Significantly Improves Image Quality and Completeness of Datasets in Real Time 3 Dimensional Echocardiography
Authors: Cezary Szmigielski, Vicente Grau, Martin Hoeschen, J. A Noble, Richard Kerber, Harald Becher
Journal: Circulation (2007)

Introduction: Real time 3 dimensional echocardiography (RT3DE) still presents a challenge for full volume acquisition in many patients because of incomplete datasets due to inadequate sector width and/or limited acoustic windows. Hypothesis: We assessed the hypothesis that fusion of standard datasets from different transducer positions improves the completeness and image quality of RT3DE. Methods: We studied 14 patients (mean age 47.0±22 yrs, 9 men, 5 women) referred for echocardiographic assessment of LV function. Standard full volume RT3DE was performed with an iE33 scanner with X3 probe (Philips Medical Systems, Andover, USA). We fused at least 2 standard RT3DE datasets from different transducer positions using a new, developed on site technique. All standard and fused datasets were processed with research software (Research Arena, TomTec, Germany). Readings were done by an experienced echocardiographer, who graded endocardial border definition and wall thickening: good quality: grade 2; intermediate: 1; poor or out of sector: 0. We studied separately segments in the short axis view (PSAX) and in apical views, yielding 32 segments per patient and total 896 cardiac segments for standard and fused datasets. Results: Table 1 summarizes the segmental quality assessments using the 2 techniques, and the number of segments per patient (mean±SD). Quality gains from grade 0 to 1 and 1 to 2 in the fused images were similarly distributed among PSAX and apical segments. Conclusions: The new fusion technique improved analysis of segmentation of the heart with RT3DE when compared with standard datasets. It increased the number of segments available for assessment and upgraded their image quality. Table 1
Imputation of missing values for electronic health record laboratory data
Authors: Jiang Li, Xiaowei S. Yan, Durgesh Chaudhary, Venkatesh Avula, Satish Mudiganti, Hannah Husby, Shima Shahjouei, Ardavan Afshar, Walter F. Stewart, Mohammed Yeasin, Ramin Zand, Vida Abedi
Journal: npj Digital Medicine (2021)

Abstract Laboratory data from Electronic Health Records (EHR) are often used in prediction models where estimation bias and model performance from missingness can be mitigated using imputation methods. We demonstrate the utility of imputation in two real-world EHR-derived cohorts of ischemic stroke from Geisinger and of heart failure from Sutter Health to: (1) characterize the patterns of missingness in laboratory variables; (2) simulate two missing mechanisms, arbitrary and monotone; (3) compare cross-sectional and multi-level multivariate missing imputation algorithms applied to laboratory data; (4) assess whether incorporation of latent information, derived from comorbidity data, can improve the performance of the algorithms. The latter was based on a case study of hemoglobin A1c under a univariate missing imputation framework. Overall, the pattern of missingness in EHR laboratory variables was not at random and was highly associated with patients’ comorbidity data; and the multi-level imputation algorithm showed smaller imputation error than the cross-sectional method.
FP08.01 Lung Stereotactic Body Radiation Therapy for Treatment of Oligoprogressive and Oligorecurrent Metastatic Disease: A Multi-Center Analysis
Authors: S. Tian, B. Kazzi, A. Mccook, J. Switchenko, W. Stokes, J. Shelton, S. Kahn, J. Carlisle, C. Steuer, T. Owonikoko, S. Ramalingam, J. Bradley, K. Higgins
Journal: Journal of Thoracic Oncology (2021)
Viral infection/reactivation during long-term follow-up in multiple myeloma patients with anti-BCMA CAR therapy
Authors: Di Wang, Xia Mao, Yimei Que, Menglei Xu, Yuhang Cheng, Liang Huang, Jue Wang, Yi Xiao, Wen Wang, Guang Hu, Shangkun Zhang, Tongcun Zhang, Chunrui Li, Jianfeng Zhou
Journal: Blood Cancer Journal (2021)

To the
P47.10 Neoadjuvant Osimertinib in EGFR-Mutant Stage IIIA/B NSCLC - A Phase 2 Open-Label Pilot Study
Authors: W. Kian, L.C. Roisman, E. Chernomordikov, A.M. Allen, B. Corn, E. Dudnik, S. Keren, M. Zemel, K. Lavrenkov, N. Peled
Journal: Journal of Thoracic Oncology (2021)
The Subjective Experience of Childhood Maltreatment in Psychopathology
Authors: Andrea Danese, Cathy Spatz Widom
Journal: JAMA Psychiatry (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Covid-19: Gun violence in US increased 30% during pandemic
Authors: Janice Hopkins Tanne
Journal: BMJ (2021)

Gun violence in the United States increased by 30% during 2020-21 from pre-pandemic levels, researchers have reported in Scientific Reports, 1 describing the situation as a public health emergency.The study found that gun related homicides, suicides, and injuries all increased during the period from 1 March 2020 to 31 March 2021 when compared with the same period in 2019-20.The authors compared gun related violence nationally, at the state level, and at different times during the pandemic.They used data compiled by the Gun Violence Archive, an independent non-profit organisation, covering all 50 US states and the District of Columbia.During the pandemic period studied the US recorded 51 063 gun related incidents, including 21 504 deaths and 43 288 injuries.This compares with 38 919 such incidents before the pandemic, including 16 687 deaths and 32 348 injuries.