tbuckley/cabot-search huggingface dataset:
Abstract PO-29: Conserved and unique transcriptional programs in human and canine non-Hodgkin lymphomas inform the judicious applications for the spontaneous canine model of disease
Authors: Aaron L. Sarver, Jaime F. Modiano
Journal: Blood Cancer Discovery (2020)

Abstract Non-Hodgkin lymphomas (NHL) represent a diverse group of tumors that are common in both humans and dogs. Extensive work has documented driver genes and inferred the cell of origin for many subtypes of human NHL, and emerging data suggest that the driver events are distinct for the corresponding subtypes of canine NHL. This raises important questions about how and when spontaneous canine NHLs can or should be considered as models for human NHLs. Here, we show the application of bioinformatics tools that allow us to systematically reduce the dimensionality of complex transcriptional patterns across independent datasets, platforms, and species, and that are capable of identifying conserved and unique traits, as well as outcome associations. The application of these tools to human and canine NHL datasets shows that, for example, the gene expression cluster that defines the germinal center-B-cell (GCB)-like subtype is exclusively present in human samples, but not in dog samples. Conversely, we confirm that non-GCB subtypes (activated B-cell [ABC] or ABC-like) include a heterogeneous group of subtypes defined by expression of shared and species-specific gene clusters, including resident or infiltrating cells that mold the stromal and immune microenvironments. Moreover, we are able to expand this approach to other subtypes of NHL to discern the contributions from stromal transcriptional programs and from lymphocyte transcriptional programs by including samples in the analyses where stromal cells were depleted. Overall, our comparative genomic approach will enhance our understanding of the conserved and species-specific events that underlie the molecular etiology of NHL, informing when spontaneous canine NHL subtypes should be considered as independent, unrelated conditions and improving and refining when and how they can be used as a relevant spontaneous model of human NHL. Citation Format: Aaron L. Sarver, Jaime F. Modiano. Conserved and unique transcriptional programs in human and canine non-Hodgkin lymphomas inform the judicious applications for the spontaneous canine model of disease [abstract]. In: Proceedings of the AACR Virtual Meeting: Advances in Malignant Lymphoma; 2020 Aug 17-19. Philadelphia (PA): AACR; Blood Cancer Discov 2020;1(3_Suppl):Abstract nr PO-29.
105P Prospective, open-label, observational study of cetuximab for metastatic colorectal carcinoma (mCRC): The OPTIM1SE study
Authors: T-S. Yang, H-H. Chen, L. Bo-Wen, T.W. Kim, I.J. Chung, J.G. Kim, J.B. Ahn, M.A. Lee, J. Lin, G.F. Ho, L.T. Anh, S. Temraz, M. Burge, C. Chua, J. Huang, Y.S. Park
Journal: Annals of Oncology (2020)
FRI0182 Catastrophic antiphospholipid antibody syndrome – report of five cases
Authors: P Barbosa, M França, I Almeida, F Farinha, C Vasconcelos
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> The catastrophic antiphospholipid antibody syndrome (CAPS) is an uncommon disorder, characterised by widespread micro and macrovascular changes due to intravascular thrombosis. We report five cases of CAPS occurred at our department over the past 7 years. <h3>Objectives</h3> <h3>Methods</h3> All patients were females between 13 and 49 years, all having SLE; two of them had no identifiable precipitant factor, two underwent major surgery, and the last one had a respiratory tract infection and a SLE flare as probable precipitant events; four women had deep vein thrombosis and the other one a peripheric arterial thrombosis; stroke occurred in 4 patients, one of them concomitantly in the right and left middle cerebral arteries terrritories; intraalveolar haemorrhage occurred in two cases and one patient developed ARDS. Treatment options were different for each patient and all had steroids and anticoagulation. Two had cyclophosphamide synchronised with plasmapheresis. <h3>Results</h3> Unfortunately 4 of the patients died, the only survivor was treated with steroids and anticoagulation therapy. <h3>Conclusion</h3> CAPS is a rare event in our cohort of patients with antiphospholipid antibody syndrome (6,9%), having a high mortality rate. Most of the times it was possible to identify a precipitant factor, namely major surgery or infection. Agressive treatment must be startted as soon as possible.
363P Genetic predisposition for pre-invasive lung adenocarcinoma manifesting as ground-glass nodules with family history of lung cancer
Authors: R. Fu, J-T. Zhang, R-R. Chen, Z-X. Tai, H-X. Lin, J. Su, X-P. Chu, C. Zhang, W-F. Tang, J-T. Lin, Q. Nie, Y-L. Wu, W-Z. Zhong
Journal: Annals of Oncology (2020)
Erratum: A unified definition of clinical resistance/intolerance to hydroxyurea in essential thrombocythemia: results of a consensus process by an international working group
Authors: G Barosi, C Besses, G Birgegard, J Briere, F Cervantes, G Finazzi, H Gisslinger, M Griesshammer, L Gugliotta, C Harrison, H Hasselbalch, E Lengfelder, J T Reilly, J J Michiels, T Barbui
Journal: Leukemia (2007)
Covid-19: UK approves Pfizer and BioNTech vaccine with rollout due to start next week
Authors: Elisabeth Mahase
Journal: BMJ (2020)

The UK’s independent Medicines and Healthcare Products Regulatory Agency (MHRA) has approved Pfizer and BioNTech’s covid-19 vaccine, with rollout now set to begin as early as next week, the government has announced.

The mRNA vaccine, BNT162b2, was found to be up to 95% effective 28 days after the first dose in a phase III trial.1 The study evaluated 170 confirmed cases of covid-19, 162 of which were observed in the placebo group. There were 10 severe cases, nine of which were in the placebo group.

The UK has secured a deal for 40 million doses of the vaccine (enough to vaccinate 20 million people), and delivery will be staggered throughout 2020 and 2021. Care home residents and workers will be prioritised to receive the vaccine first, followed by healthcare workers and people over 80.

A spokesperson for the Department of Health and Social Care said, “The vaccine will be made available across the UK from next week. The NHS has decades of experience in delivering …
Abstract 385: Family Presence During Resuscitation: A Needs Assessment
Authors: Carolina Tennyson
Journal: Circulation (2019)

Introduction: Evidence is mounting that appropriate family presence during resuscitation (FPDR) can be beneficial to patients and their families including lower rates of post-traumatic stress disorder after the event. Despite this, FPDR has not been widely adapted and continues to have legitimate barriers. Therefore, the focus of this quality improvement project was to conduct an organizational needs assessment at Duke University to create a systematic FPDR guideline that can be consistently implemented across the hospital. Methods: A 17-question survey tool was created using Ottowa Decision Making Framework and distributed to all members of a Cardiothoracic Intensive Care Unit code team including physicians, advanced practice providers, nurses, respiratory therapists, chaplains, perfusionists, pharmacists and social workers. The questions addressed FPDR experience, decision making influencers, situational comfort, and demographics. Results: There was a total of 200 responses. 46.6% Registered Nurses, 7.3% were Advanced Practice Providers, 7.8% Attending Physician, 6.2% Resident Physicians, 19.2% Respiratory therapists, 2.5% Chaplains. Four themes emerged - comfort based on experience, support for early chaplain involvement, need of family facilitator role, and absolute resistance. Multiple concerns were raised by the surveyed healthcare providers including logistics, risk for legal retribution, distraction from resuscitation, family suffering, and ill preparedness regarding FPDR. 72% of the respondents endorsed utilizing a family facilitator role to support the practice of FPDR. There was wariness regarding using the term ‘protocol’ for the guideline document. Conclusions: There are varying levels of comfort and support regarding the practice of FPDR amongst the resuscitation team. Many healthcare professionals acknowledge a need for family facilitation with a dedicated staff member, while others respond with a resolute unwillingness to practice FPDR. There is a need for education and publication of guidelines to assist staff in gaining consistency and confidence in the practice of FPDR.
Proton pump inhibitor or famotidine use and severe COVID-19 disease: a propensity score-matched territory-wide study
Authors: Jiandong Zhou, Xiansong Wang, Sharen Lee, William Ka Kei Wu, Bernard Man Yung Cheung, Qingpeng Zhang, Gary Tse
Journal: Gut (2020)

<h3>Introduction</h3> From 2005, lay representatives (‘Research Partners-RPs) have been involved as memebers of the research team in a clinical trials unit, and more recently a Marie Curie facility. However, the impact of their work has not been routinely examined. The TACT study was designed as a means of evaluation. <h3>Aim(s) and method(s)</h3> Semi-structured interviews were conducted with ten RPs and eight researchers to explore RPs’ input; documents from Trial Management Groups (TMGs), emails and relevant outputs were analysed using a Framework approach. <h3>Results</h3> Both the RPs and researchers saw the RP as an advocate for patients. RPs generally felt welcomed into the trials unit with most happy with their level of involvement. However, some RPs spoke about a perceived bias in the unit9s tendency to use more experienced RPs, the RP role being a tokenistic funding requirement, and the need for greater monitoring and support. Researchers were unclear about the degree to which RPs should be involved in their work and the processes involved in working alongside RPs. They recognised greater commitment was required of them in the RP initiative, although time pressures and stresses were barriers to achieving this. Analysis of RP Impact led to generally unfavourable results. Evidence of input in TMGs did not equate with subsequent actions and contributions in outputs were either minimal or absent. <h3>Conclusions</h3> Despite, a structured model of RP involvement, the results show a need for further improvement. Work is currently underway to design and implement a toolkit with which to tackle some of these challenges.
Attenuated Interferon-α Targeted to CD38 Expressing Multiple Myeloma Tumor Cells Induces Robust and Durable Anti-Tumor Responses through Direct Anti-Proliferative Activity in Addition to Indirect Recruitment and Activation of M1 Macrophages
Authors: Sarah Pogue, Mingying Bi, Mark Armanini, Marjan Fatholahi, Tetsuya Taura, Miriam Valencia, Yong Yun, Angela Sho, Anita Jamin, Steffen Nock, David S. Wilson
Journal: Blood (2017)
Who Is David and Who Is Goliath?: There Is an Urgent Need to Improve the Reference Standards for Estimation of Myocardial Infarct Size⁎⁎Editorials published in JACC: Cardiovascular Imaging reflect the views of the authors and do not necessarily represent the views of JACC: Cardiovascular Imaging or the American College of Cardiology.
Authors: Hugo A. Katus, Evangelos Giannitsis
Journal: JACC. Cardiovascular imaging (2011)
The use of observational research to inform clinical practice
Authors: Nigel Paneth, Michael Joyner
Journal: Journal of Clinical Investigation (2020)

Randomized controlled trials are the preferred design for the analysis of health-related interventions. In this Viewpoint, Nigel Paneth and Michael Joyner discuss circumstances when randomized controlled trials might not be feasible and the criteria that should be used when considering applying observational data medicine.
Vertical integration of hospitals and GPs has saved some practices but should not be imposed, evaluation finds
Authors: Gareth Iacobucci
Journal: BMJ (2020)

The process of hospital trusts taking over the running of primary care services has saved some GP surgeries from closure but should not be imposed on practices, an evaluation has concluded.

A study by the University of Birmingham and RAND Europe1 examined the rationale for and the early impact of vertical integration at two locations in England and one in Wales. It combined a review of existing evidence with interviews of 52 people involved in the three case study sites, including GPs and NHS managers.

Across the three sites, the authors found that the main driver and rationale of vertical integration had been …
SP0132 Education can reduce pain experience among elder women with osteoporosis
Authors: TS Søyseth, V Søyseth
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Introduction</h3> Pain and fear of fractures are very common among patients with osteoporosis reducing their activity of daily living and quality of life. We have investigated the effect of education or education in combination with physical training on pain experience in women with osteoporosis. <h3>Methods</h3> Women older than 60 years with osteoporosis (N = 49) were enrolled in the study. All were able to walk indoor without technical support. Bone density was assessed using a DXA-machine. All were hospitalised for five days in a hospital of rheumatology. They were casually put into two different treatment programs: Education (n = 26) Education in combination with physical training (n = 23) The education program was provided by a team of professional health workers and had a multifactorial approach to problems experienced by patient with osteoporosis. The physical training program was leaded by physiotherapists. Health was assessed by SF-36 questionnaire at baseline, and then after 3 and 12 months. <h3>Results</h3> A multivariate analysis for repeated measurements showed an improvement of bodily pain score of 7.4 (95% CI 2.7–12.1) after 3 month and 9.8 (95% CI 4.2–15.4) after 1 year compared with baseline. There were no significant differences between the groups. Physical activity and social function were also statistical improved at 3 month, but the improvement did not persist for the complete follow-up period. <h3>Conclusion</h3> Participation a professional education program reduces the pain experience in women with osteoporosis, and the improvement appear to persist for at least one year. This result needs confirmation by further studies.
Response to Brinkmann et al. “Re-assembly of 19th century smallpox vaccine genomes reveals the contemporaneous use of horsepox and horsepox-related viruses in the United States”
Authors: Ana T. Duggan, Edward C. Holmes, Hendrik N. Poinar
Journal: Genome biology (2020)

Abstract We thank Brinkmann and colleagues for their correspondence and their further investigation into these American Civil War Era vaccination strains. Here, we summarize the difficulties and caveats of work with ancient DNA.
Antibiotics on Par With Surgery for Appendicitis
Authors: Anita Slomski
Journal: JAMA (2020)

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13115 Serum infliximab level in an infant delivered from a mother with psoriatic arthritis receiving infliximab
Authors: Takeko Ishikawa, Shuko Takeuchi, Masahiro Kamata, Hideaki Uchida, Mayumi Nagata, Saki Fukaya, Kotaro Hayashi, Atsuko Fukuyasu, Takamitsu Tanaka, Takamitsu Ohnishi, Yayoi Tada
Journal: Journal of the American Academy of Dermatology (2020)
Bortezomib, thalidomide, and dexamethasone with or without daratumumab for transplantation-eligible patients with newly diagnosed multiple myeloma (CASSIOPEIA): health-related quality of life outcomes of a randomised, open-label, phase 3 trial
Authors: Murielle Roussel, Philippe Moreau, Benjamin Hebraud, Kamel Laribi, Arnaud Jaccard, Mamoun Dib, Borhane Slama, Véronique Dorvaux, Bruno Royer, Laurent Frenzel, Sonja Zweegman, Saskia K Klein, Annemiek Broijl, Kon-Siong Jie, Jianping Wang, Veronique Vanquickelberghe, Carla de Boer, Tobias Kampfenkel, Katharine S Gries, John Fastenau, Pieter Sonneveld
Journal: The Lancet Haematology (2020)
How to Supplement Endpoints of Ventricular Tachycardia Ablation: Is There a Role for Noninvasive Programmed Ventricular Stimulation?⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Authors: Gerhard Hindricks, Christopher Piorkowski
Journal: Journal of the American College of Cardiology (2012)
Abstract PO-026: Analysis of metabolic adaptations in HeLa cells as a function of energy status using a novel, direct ATP chelation methodology
Authors: Ashley P. Brown, Taha Muhammad, Selina Martinez, Shaleen B. Korch, Jeffrey Norris
Journal: Cancer Research (2020)

Abstract Introduction: Since pioneering studies by Otto Warburg demonstrated that cancer cells had markedly reduced oxidative phosphorylation under conditions of high oxygen tension (Warburg Effect/aerobic glycolysis), metabolic reprogramming has become a well-recognized hallmark of cancer. While numerous discoveries have revealed highly specific metabolic differences between cancer cells, utilization of aerobic glycolysis as the primary means of ATP generation remains one of the most common metabolic alterations observed across a range of cancers. Gain-of-function mutations in p53 (mutp53) occur with a frequency of greater than 50% in many types of cancers and promote aerobic glycolysis by activation of glycolysis and inhibition of the tricarboxylic acid cycle. However, the manner by which these mutp53 regulates metabolic shifts in response to energy strain is only beginning to be elucidated. Hypothesis: Increased energy demand by cells caused by direct chelation of ATP by the novel, synthetic ATP-binding protein DX will be met by increases primarily in oxygen consumption. Methods: A cationic lipid mixture was complexed with active, purified DX protein to generate a DX/lipid complex. HeLa cells were incubated with the DX/lipid complex to allow efficient delivery of DX into the cytoplasm of the HeLa cells. The XF Real-Time ATP Rate Assay using Seahorse XF label-free technology was used to measure the rate of ATP production following DX expression and estimate the relative contributions of glycolysis and oxidative phosphorylation to the total ATP production rate. Results: HeLa cells transfected with DX had reduced viability, altered morphology, and decreased bioavailable intracellular ATP following DX expression. Unexpectedly, in response to DX expression and reduction in ATP, total ATP production rates in HeLa cells significantly decreased over time. Importantly, this drop in total ATP production was associated with a metabolic pathway utilization shift. Conclusion: The synthetically derived DX protein is a tool that allows for direct control of the ATP levels in cancer cells and has the potential to reveal novel metabolic adaptive responses to energy stress. Following regulated ATP reduction in HeLa cells, changes observed in the OXPHOS/glycolytic balance represent an overall cellular metabolic shift. Citation Format: Ashley P. Brown, Taha Muhammad, Selina Martinez, Shaleen B. Korch, Jeffrey Norris. Analysis of metabolic adaptations in HeLa cells as a function of energy status using a novel, direct ATP chelation methodology [abstract]. In: Abstracts: AACR Special Virtual Conference on Epigenetics and Metabolism; October 15-16, 2020; 2020 Oct 15-16. Philadelphia (PA): AACR; Cancer Res 2020;80(23 Suppl):Abstract nr PO-026.
Abstract 17935: The Prevalence and Outcome of Diabetic Cardiomyopathy
Authors: Aaron M From, Joshua Slusser, Douglas W Mahoney, Margaret M Redfield, Richard Rodeheffer, Horng H Chen
Journal: Circulation (2010)

Background: Diabetic cardiomyopathy defined as either systolic or diastolic dysfunction in otherwise healthy diabetic persons is not clearly understood. The prevalence and outcome of this disease i...
Low cardiorespiratory and mitochondrial fitness as risk factors in viral infections: implications for COVID-19
Authors: Johannes Burtscher, Grégoire P Millet, Martin Burtscher
Journal: British Journal of Sports Medicine (2020)

<h3>Abstract</h3> The study was conducted on 50 samples of coffee beans from various origins. The samples included green coffee beans, roasted beans, brew coffee drinks and coffee sludge. Three processes were used to prepare these samples: dried, semi-washed, and washed. Three synthetic pyrethroid insecticides and nine heavy metals were subsequently analyzed using modified Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) and acid digestion methods, respectively. The quantification of pyrethroids was performed by GC-μECD whereas those of metals were determined using flame atomic absorption spectrophotometer. According to the results, concentrations of both pyrethroids and heavy metals were predominantly found in green coffee beans except for Cr. Pyrethroid insecticides were not detectable in brew coffee drink and heavy metal concentrations were below the acceptable daily intake (ADI) level. Risk estimations for daily coffee intake using the health risk indices (HRIs) and target hazard quotients (THQs) of normal and the 97.5 percentile Thai consumers were less than 1. This indicated that the coffee drinks from studied samples could not cause potential health risk.
Addition of chemotherapy to local therapy in women aged 70 years or older with triple-negative breast cancer: a propensity-matched analysis
Authors: Jennifer A Crozier, Todd A Pezzi, Caitlin Hodge, Slavica Janeva, Beth-Ann Lesnikoski, Laila Samiian, Amanda Devereaux, William Hammond, Riccardo A Audisio, Christopher M Pezzi
Journal: The Lancet Oncology (2020)
2020 Focused Updates to the Asthma Management Guidelines: A Report from the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group
Authors: Michelle M Cloutier, Alan P Baptist, Kathryn V Blake, Edward G Brooks, Tyra Bryant-Stephens, Emily DiMango, Anne E Dixon, Kurtis S Elward, Tina Hartert, Jerry A Krishnan, Robert F Lemanske, Daniel R Ouellette, Wilson D Pace, Michael Schatz, Neil S Skolnik, James W Stout, Stephen J Teach, Craig A Umscheid, Colin G Walsh
Journal: Journal of Allergy and Clinical Immunology (2020)
Redox-responsive polyethyleneimine/tetrahedron DNA/doxorubicin nanocomplexes for deep cell/tissue penetration to overcome multidrug resistance
Authors: Jianqin Yan, Nan Zhang, Zhuangzhuang Zhang, Wangwei Zhu, Bing Li, Li Li, Yuji Pu, Bin He
Journal: Journal of Controlled Release (2020)