tbuckley/cabot-search huggingface dataset:
Platelet aggregation in the cerebral microcirculation: effect of aspirin and other agents.
Authors: W IRosenblum, FEl-Sabban
Journal: Circulation Research (1977)

After a certain period of  filtered ultraviolet light produces platelet  in microvessels on the cerebral surface of the mouse, but only when sodium fluorescein is first injected intravascularly to provide a light-absorbing, heat-generating target. The platelet aggregates fluoresce. They occur only in the illuminated field and adhere to arteriolar and venular walls. Vasoconstriction is not detected prior to or up to 30 seconds after aggregation. Electron microscopy reveals damaged endothelium and undamaged red cells, as well as aggregates consisting almost exclusively of platelets in varying stages of aggregation, pseudopod formation, and degranulation. The  between onset of the noxious stimulus and recognition of the first aggregate can be measured as the vessels are observed microscopically. This time of aggregation is prolonged by pentobarbital as opposed to urethane anesthesia, and also is related to  elapsed after craniotomy. We also found that aspirin and indomethacin signifi...
Effects of decreasing arterial blood pressure on cerebral blood flow in the baboon. Influence of the sympathetic nervous system.
Authors: WFitch, E TMacKenzie, A MHarper
Journal: Circulation Research (1975)

The influence of the sympathetic nervous system on the cerebral circulatory response to graded reductions in mean arterial blood pressure was studied in anesthetized baboons. Cerebral blood flow was measured by the 133Xe clearance method, and arterial blood pressure was decreased by controlled hemorrhage. In normal baboons, the constancy of cerebral blood flow was maintained until mean arterial blood pressure was approximately 65% of the base-line value; thereafter, cerebral blood flow decreased when arterial blood pressure was reduced. Superior cervical sympathectomy of 2-3 weeks duration did not affect the normal response. In contrast, both acute surgical sympathectomy (cervical trunk division) and alpha-receptor blockade (1.5 mg/kg of phenoxybenzamine) enhanced the maintenance of cerebral blood flow in the face of hemorrhagic hypotension in that cerebral blood flow did not decrease until mean arterial blood pressure was approximately 35% of the base-line value. The results indicate that the sympathetic...
The role of right ventricular systolic dysfunction and elevated intrapericardial pressure in the genesis of low output in experimental right ventricular infarction.
Authors: J AGoldstein, G JVlahakes, E DVerrier, N BSchiller, J VTyberg, T APorts, W WParmley, KChatterjee
Journal: Circulation (1982)

To elucidate the pathophysiology of severe right ventricular infarction (RVI), isolated RVI was produced in 15 dogs with the pericardium intact or open. After RVI in dogs with the pericardium intact, RV systolic pressure decreased by 27%, aortic pressure by 29% and cardiac output by 34%. RV transmural pressure, RV end-diastolic size and intrapericardial pressure increased, left ventricular transmural pressure and end-diastolic size decreased and the diastolic pressures equalized. Pericardiotomy after RVI resulted in increased ventricular transmural pressures and diastolic size, improved cardiac output and resolution of equalized diastolic pressures. RVI in dogs with the pericardium open resulted in similar changes, but of lesser magnitude and without equalization of diastolic pressures. These results indicate that reduced left ventricular preload due to impaired RV systolic function contributes to low cardiac output in RVI. Elevated intra-pericardial pressure further reduced left ventricular preload and p...
Comparison between the effects of nitroprusside and nitroglycerin on ischemic injury during acute myocardial infarction.
Authors: MChiariello, H KGold, R CLeinbach, M ADavis, P RMaroko
Journal: Circulation (1976)

This clinical and experimental investigation was designed to delineate and compare the relative effects of sodium nitroprusside (NP) and nitroglycerin (TNG) on electrocardiographic ischemic injury following acute myocardial infarction in patients and following coronary artery occlusion in dogs. Accordingly, in ten patients with anterior acute myocardial infarction and ST-segment elevation stable for 60 min, the effects of NP (average 95 mug/min i.v.) and TNG (average 0.48 mg sublingually) were studied. The hemodynamic actions of NP and TNG were directionally similar. However, NP increased average ST-segment elevation (ST) by 2.0 +/- 0.2 mm, while TNG reduced ST by 1.4 +/- 0.4 mm. In order to clarify this disparity, coronary artery occlusions were carried out in 14 open-chest dogs. During control, NP and TNG time periods, epicardial electrograms were recorded and regional myocardial blood flow (RMBF) determined by the microsphere technique. Nitropruside increased ST-segment elevation from 4.6 +/- 0.6 to 5....
Cost-effectiveness of a Smoking Cessation Intervention for Parents in Pediatric Primary Care
Authors: Olivier Drouin, Ryoko Sato, Jeremy E. Drehmer, Emara Nabi-Burza, Bethany Hipple Walters, Jonathan P. Winickoff, Douglas E. Levy
Journal: JAMA Network Open (2021)

Parental smoking adversely affects parents' and children's health. There are effective interventions delivered in pediatric settings to help parents quit smoking. The cost-effectiveness of this type of intervention is not known.To evaluate the cost-effectiveness of a parental smoking cessation intervention, the Clinical Effort Against Secondhand Smoke Exposure (CEASE) program, delivered in pediatric primary care, compared with usual care from a health care organization's perspective.This economic evaluation used data on intervention costs and parental smoking cessation collected prospectively as part of the CEASE randomized clinical trial. Data were collected at pediatric offices in 5 US states from April 2015 to October 2017. Participants included parents of children attending 10 pediatric primary care practices (5 control, 5 intervention). Data analysis was performed from October 2019 to August 2020.The trial compared CEASE (practice training and support to address family tobacco use) vs usual care.The overall cost and incremental cost per quit of the CEASE intervention were calculated using microcosting methods. CEASE effectiveness was estimated using 2 trial outcomes measures assessed in repeated cross-sections: (1) change in smoking prevalence assessed by parental report for intervention vs usual care practices at 2 weeks after program initiation (baseline) and at 2-year follow-up and (2) changes in the proportion of smokers who achieved cotinine-confirmed smoking cessation in the previous 2 years at baseline vs follow-up. Monte Carlo analyses were used to provide 95% CIs.The study included a total of 3054 participants (1523 at baseline and 1531 at follow-up); 2163 (70.8%) were aged 25 to 44 years old, and 2481 (81.2%) were women. Over 2 years, the total cost of implementing and sustaining CEASE across 5 intervention practices was $115 778. The incremental cost per quit for CEASE compared with usual care was $1132 (95% CI, $653-$3603), according to the change in parent-reported smoking prevalence, and $762 (95% CI, $418-$2883), according to cotinine-confirmed cessation. CEASE was cost-effective at a willingness-to-pay threshold of $2000 per quit in 88.0% of simulations based on the parent-reported smoking prevalence and 94.6% of simulations based on cotinine-confirmed smoking cessation measures.These findings suggest that the CEASE intervention was associated with an incremental cost per quit that compared favorably with those of other clinical smoking cessation interventions. CEASE is inexpensive to initiate and maintain in the clinical pediatric setting, suggesting that it has the potential for a high impact on population health.
Hyperplastic Gastric Polyps: about 74 Cases
Authors: S Bradai, A Khsiba, M Mahmoudi, A Ben Mohamed, M Medhioub, L Hamzaoui, MM Azzouz
Journal: Endoscopy (2021)

Aims Hyerplastic polyps are among the most common gastric polyps. They are most commonly associated with chronic gastritis (Helicobacter pylori or autoimmune-induced). The aim of this work is to study the clinical, endoscopic and histopathological aspects of hyperplastic gastric polyps.
Pulse wave propagation.
Authors: J KLi, JMelbin, R ARiffle, ANoordergraaf
Journal: Circulation Research (1981)

This report evaluates pulse wave propagation with respect to contributions by vascular wall elastic and geometric properties, vessel wall and blood viscosity, and nonlinearities in system parameters and in the equations of motion. Discrepancies in results obtained with different experimental methods and theory are discussed and resolved. A three-point pressure technique was used to obtain measurements from the abdominal aorta, carotid, iliac, and femoral arteries of dogs. Computations involved linear, as well as nonlinear methods. Results are presented along a continuous path of transmission (abdominal aorta, iliac, femoral), and it is shown that variations in phase velocity can be explained entirely by the geometric variation of these vessels. Phase velocities are shown to be frequency independent at approximately greater than 4 Hz whereas attenuation increases progressively for higher frequencies. Determination of propagation coefficients using maximal, compounded values of reported viscoelastic and geo...
10 Years Of Experience With Eosinophilic Esophagitis In Five Czech Pediatric Endoscopy Centers
Authors: J Pecl, P Jabandziev, L Kunovsky, J Vaculova, E Karaskova, A Sulakova, L Toukalkova, M Zimen
Journal: Endoscopy (2021)

Aims Eosinophilic esophagitis (EoE) is a chronic, progressive inflammatory disease of the esophagus characterized by local eosinophilic infiltration accompanied by symptoms of esophageal dysfunction. EoE may affect individuals at any age, although the clinical presentation and relevant triggers are different among children and adult patients. The aim of this study was to characterize features and management of pediatric EoE diagnosed in Czech Republic.
Shall The Journal be Removed to Washington?
Authors: D. L. Sauerhering
Journal: JAMA (1891)

Chicago is not only the geographic and railroad centre of our country, but is also a great metropolis, with im- mense and constantly increasing medical, literary and business interests springing up within it and flowing toward it from all parts of the Union, will give to The Journal an \l=e'\clatand high professional position, that will add greatly to its power, and widen its influence be- yond anything that could possibly be hoped for were it a fixture in Washington.It is appropriate that the representative of American medicine should have its home in the representative Am- erican city, which is Chicago.This city can also place at the disposal of the management a wealth of resource second to but one in this country, and if not now will very soon be first in this respect.In comparison with this anything Washington could ever offer would seem poverty-stricken.
The effects of shortening on myoplasmic calcium concentration and on the action potential in mammalian ventricular muscle.
Authors: M JLab, D GAllen, C HOrchard
Journal: Circulation Research (1984)

When cardiac muscle shortens during a contraction, the duration of mechanical activity is abbreviated (shortening deactivation), but the duration of the action potential is prolonged. Neither of these phenomena is fully understood, but both may be related to changes in the myoplasmic free calcium concentration. In these experiments, isolated papillary muscles from cats and ferrets were allowed to contract under various mechanical conditions while myoplasmic calcium was monitored with aequorin, or in parallel experiments the membrane potential was recorded with microelectrodes or a sucrose gap. When shortening occurred, myoplasmic calcium was increased and the membrane potential was more positive than in isometric contractions. The changes in calcium apparently precede the depolarization. We propose that muscle shortening reduces calcium binding to the contractile proteins and leads to a rise in myoplasmic calcium, and that this rise in myoplasmic calcium activates an inward current leading to the observed...
Implementing Measurement Science for Electronic Health Record Use
Authors: Edward R. Melnick, Christine A. Sinsky, Harlan M. Krumholz
Journal: JAMA (2021)

Jason S. Adelman, MD, MS; Jo R. Applebaum, MPH; Clyde B. Schechter, MD, MA; Matthew A. Berger, MD; Stan H. Reissman, MSW; Raja Thota, MS; Andrew D. Racine, MD, PhD; David K. Vawdrey, PhD; Robert A. Green, MD, MPH; Hojjat Salmasian, MD, MPH, PhD; Gordon D. Schiff, MD; Adam Wright, PhD; Adam Landman, MD; David W. Bates, MD, MSc; Ross Koppel, PhD; William L. Galanter, MD, PhD, MS; Bruce L. Lambert, PhD; Susan Paparella, MSN, RN; William N. Southern, MD, MS
Prognostic significance of Doppler measures of diastolic function in cardiac amyloidosis. A Doppler echocardiography study.
Authors: A LKlein, L KHatle, C PTaliercio, J KOh, R AKyle, M AGertz, K RBailey, J BSeward, A JTajik
Journal: Circulation (1991)

BACKGROUNDWe have previously characterized the left ventricular diastolic filling abnormalities in cardiac amyloidosis by Doppler methods. The various filling patterns were shown to be related to the degree of cardiac amyloid infiltration. The purpose of this study was to determine the value of Doppler diastolic filling variables for assessing prognosis in cardiac amyloidosis.METHODS AND RESULTSWe performed pulsed-wave Doppler studies of the left ventricular inflow and obtained clinical follow-up data in 63 consecutive patients with biopsy-proven systemic amyloidosis. All patients had typical echocardiographic features of cardiac involvement. The patients were subdivided into two groups according to deceleration time: Group 1 (33 patients) had a deceleration time of 150 msec or less, indicative of restrictive physiology, and group 2 (30 patients) had a deceleration time of more than 150 msec. Of the 63 patients, 32 (51%) died during a mean follow-up period of 18 +/- 12 months. Of these deaths, 25 (78%) we...
To the Editors
Authors: A. Bush, F. M. de Benedictis, G. Hedlin, J. Y. Paton, G. Wennergren, N. M. Wilson
Journal: European Respiratory Journal (2009)

asthma as close to control as possible and is acceptable to both the patient and physician''.''Minimal level'' of treatment and the duration of the periods where asthma control is maintained need to be specified further.An algorithm of this type may fit well with a treatment principle where control is obtained rapidly and diagnosis confirmed in the first step.In the following steps, the treatment is optimised alongside with the education of the patient.
Quantification of intestinal microvascular growth during maturation: techniques and observations.
Authors: J LUnthank, H GBohlen
Journal: Circulation Research (1987)

This study was undertaken to determine what changes occur in the intestinal microvasculature during the rapid growth associated with juvenile maturation. A technique was developed that permitted the comparison of the same microvessels in exactly the same intestinal region at two time periods of an animal's life. A region of the terminal ileum of 5-week-old rats was exposed and marked, and photographs and video recordings were made of the microvessels. Four weeks later, the marked intestinal region was located, and photography and videography of the microvessels were repeated. Comparison of indexes for body, intestinal, and microvascular growth for the treated rats and age- and colony-matched controls revealed no significant differences. The number and branching pattern of arterioles observed in the marked region remained remarkably constant during the 4 weeks between observation periods, even though body and bowel mass of the treated animals increased approximately 2.5 times. The lengths of the arterioles...
Re-entrant ventricular arrhythmias in the late myocardial infarction period. 2. Patterns of initiation and termination of re-entry.
Authors: NEl-Sherif, R RHope, B JScherlag, RLazzara
Journal: Circulation (1977)

The electrophysiologic mechanisms for the initiation and termination of re-entrant ventricular arrhythmias (RVA) were critically analyzed in dogs 3-7 days following ligation of the anterior descending coronary artery, utilizing direct recordings of the re-entrant pathway (RP) from the epicardial surface of the infarction zone. Re-entry could occur during a regular cardiac rhythm if the heart rate is within the narrow critical range during which conduction in a potentially RP exhibits a Wenckebach-like (W) pattern with a beat-to-beat increment of conduction delay until the activation waveform is sufficiently delayed to re-excite normal myocardium. If a regular cardiac rhythm is associated with limited conduction delay in a potentially RP, premature beats within a critical range of coupling intervals could result in sufficient conduction delay to induce re-entry. Re-entrant ventricular arrhythmias may be unmasked on abrupt termination of a critical fast rate of cardiac pacing only if pacing was terminated d...
Development of a EUCAST disk diffusion method for the susceptibility testing of rapidly growing anaerobic bacteria using Fastidious Anaerobe Agar (FAA): a development study using Bacteroides species
Authors: Herjan Bavelaar, Ulrik Stenz Justesen, Trefor E. Morris, Bethan Anderson, Sarah Copsey-Mawer, Tore Taksdal Stubhaug, Gunnar Kahlmeter, Erika Matuschek
Journal: Clinical Microbiology and Infection (2021)
Response to Letter Regarding Article, “Human C-Reactive Protein Does Not Promote Atherosclerosis in Transgenic Rabbits”
Authors: TomonariKoike, YingYu, JifengZhang, JianglinFan, YukioOzaki, ShujiKitajima, KazutoshiNishijima, MasatoshiMorimoto, TeruoWatanabe, SucharitBhakdi, YujiroAsada, Y. EugeneChen
Journal: Circulation (2010)
The role of the renin-angiotensin system in mediation of adrenal catecholamine secretion in the cat induced by intrarenal beta-adrenergic stimulation.
Authors: M MKrausz, GFeuerstein, NFeuerstein, YGutman
Journal: Circulation Research (1980)

Isoproterenol infusion (0.1 microgram/kg per min) into the renal artery of the cat induced an increase in plasma renin concentration (PRC) from 14.3 +/- 5.7 (mean +/- SE) ng angiotensin I/ml per hr to 56.8 +/- 7.7 after 70 minutes (P < 0.05) and an increase in catecholamine secretion rate from 38.7 +/- 6.0 ng/kg per 10 min to 180.0 +/- 40.0 after 70 minutes (P < 0.001). Intravenous infusion of the same dose of isoproterenol had no significant effect on adrenomedullary catecholamine secretion rate. Isoproterenol induced preferential norepinephrine release: the ratio of norepinephrine to epinephrine secretion changed from 11.5:23.7 during the control period to 130.0:40.1 70 minutes after the start of isoproterenol administration. Intrarenal infusion of propranolol (3.0 mg/kg per min) inhibited renal renin release and adrenal catecholamine secretion in response to intrarenal isoproterenol. Intravenous infusion (0.4 microgram/kg per min) of an angiotensin II antagonist [Sar1, Ileu8]angiotensin II abolished th...
Clinical Validation Of Acer, GSSED-RE, GSSED-RE2 Scores For Prediction Of Delayed Bleeding After Endoscopic Mucosal Resection Of Large Colorectal Lesions
Authors: A Kamal, VS Akshintala, DK Rex, Y Ichkanian, MK Hasan, D Pleskow, BJ Elmunzer, PA Elias, A Mathew, M Pellise, R Law, SB Kavuri, MM Kamal, H Pohl, MA Khashab
Journal: Endoscopy (2021)

Aims Several risk factors have been proposed to predict delayed bleeding (DB) after EMR of large colon polyps. Three prediction models (ACER, GSSED-RE, GSSED-RE2) evaluated risk factors, of which GSSED-RE2 reported the highest prediction scores (AUC 0.71). We aimed to validate these three scoring systems for their accuracy to predict DB.
MYC-Activated LncRNA <i>MNX1-AS1</i> Promotes the Progression of Colorectal Cancer by Stabilizing YB1
Authors: Qi-Nian Wu, Xiao-Jing Luo, Jia Liu, Yun-Xin Lu, Yun Wang, Jingjing Qi, Ze-Xian Liu, Qi-Tao Huang, Ze-Kun Liu, Jia-Bin Lu, Ying Jin, Heng-Ying Pu, Pei-Shan Hu, Jia-Bo Zheng, Zhao-Lei Zeng, Huai-Qiang Ju, Dan Xie, Qi Zhao, Ruihua Xu
Journal: Cancer Research (2021)

Abstract Long noncoding RNAs (lncRNA) are involved in tumorigenesis and drug resistance. However, the roles and underlying mechanisms of lncRNAs in colorectal cancer are still unknown. In this work, through transcriptomic profiling analysis of 21 paired tumor and normal samples, we identified a novel colorectal cancer–related lncRNA, MNX1-AS1. MNX1-AS1 expression was significantly upregulated in colorectal cancer and associated with poor prognosis. In vitro and in vivo gain- and loss-of-function experiments showed that MNX1-AS1 promotes the proliferation of colorectal cancer cells. MNX1-AS1 bound to and activated Y-box-binding protein 1 (YB1), a multifunctional RNA/DNA-binding protein, and prevented its ubiquitination and degradation. A marked overlap between genes that are differentially expressed in MNX1-AS1 knockdown cells and transcriptional targets of YB1 was observed. YB1 knockdown mimicked the loss of viability phenotype observed upon depletion of MNX1-AS1. In addition, MYC bound the promoter of the MNX1-AS1 locus and activated its transcription. In vivo experiments showed that ASO inhibited MNX1-AS1, which suppressed the proliferation of colorectal cancer cells in both cell-based and patient-derived xenograft models. Collectively, these findings suggest that the MYC–MNX1-AS1–YB1 axis might serve as a potential biomarker and therapeutic target in colorectal cancer. Significance: This study highlights the discovery of a novel colorectal cancer biomarker and therapeutic target, MNX1-AS1, a long noncoding RNA that drives proliferation via a MYC/MNX1-AS1/YB1 signaling pathway.
Fetal blood volume responses to acute fetal hemorrhage.
Authors: R ABrace
Journal: Circulation Research (1983)

The purpose of this study was to explore the changes in fetal blood volume that occur after fetal hemorrhage. Fifteen unanesthetized, chronically catheterized fetal sheep averaging 130 +/- 3 (SD) days gestation were studied 4 to 6 (average 5) days after catheter implantation. The fetuses were hemorrhaged by continuous withdrawal from an arterial catheter over 5 minutes. On the average (n = 15), 13.9 +/- 5.3% of the initial volume was removed. Fluid gradually entered the fetal circulation during and after the hemorrhage. Thirty minutes after hemorrhage had been initiated, 53.0 +/- 22.0% restitution of the lost volume occurred. Thus, short-term fetal blood volume restitution after fetal hemorrhage averaged about twice that of the adult. Hemorrhages averaging 7.3 +/- 2.3% (n = 3), 12.9 +/- 1.0% (n = 8), and 21.0 +/- 3.3% (n = 4) were followed by 55.7 +/- 13.3%, 54.7 +/- 26.4%, and 47.7 +/- 19.9% restitution, respectively. Thus, fractional volume replacement appears independent of the shed volume over the ran...
Overestimation of pediatric cardiac output by thermal indicator loss.
Authors: G FMaruschak, A MPotter, J FSchauble, M CRogers
Journal: Circulation (1982)

The accurate measurement of pediatric cardiac output by thermodilution requires that the quantity of cold indicator introduced into the central circulation be known. This study defines an important source of error in the correction factor for the amount of heat gained by small volumes of cold injectate during passage through pediatric catheter systems. This error may result in significant overestimation of cardiac output (as much as 59%) when blood at body temperature is withdrawn into the injection lumen of the pediatric catheter before the injection.