tbuckley/cabot-search huggingface dataset:
OP0110 A COHORT STUDY ON THE BIDIRECTIONAL RELATIONSHIP BETWEEN PERIODONTITIS AND OSTEOARTHRITIS OVER A 15-YEAR FOLLOW-UP
Authors: K. S. K. MA, E. Thota, T. Van Dyke
Journal: Annals of the Rheumatic Diseases (2021)

Background: Recently, osteoarthritis has been proposed to be driven by complement-mediated inflammatory cascades. That is, in addition to the conventional degenerative model, our knowledge of osteoarthritis pathogenesis has been expanded with an inflammation-dependent theory. Objectives: To identify the relationship between osteoarthritis and periodontitis. Methods: 144,788 periodontitis patients and 144,788 propensity score-matched controls without history of periodontitis were enrolled in this cohort study. A Cox proportional hazard model was used to estimate the risk of osteoarthritis. Survival analysis was utilized to assess the time-dependent effect of periodontitis on osteoarthritis. Age and gender were stratified to identify susceptible subgroups. A symmetrical case-control analysis was designed to determine the relationship between periodontitis and history of osteoarthritis. Results: Patients with periodontitis had higher risk of osteoarthritis (HR =1.15, 95% CI =1.12–1.17, P &lt; 0.001) and severe osteoarthritis that led to total knee/hip replacement (HR =1.12, 95% CI =1.03–1.21, P &lt; 0.01) than controls, which was time-dependent (log-rank test P &lt; 0.01). The effect of periodontitis on osteoarthritis was significant in both genders and age subgroups over 30 years old (all P &lt; 0.001). Among them, females (HR=1.27, 95% CI = 1.13–1.42, P &lt; 0.001) and patients aged over 51 (HR= 1.21, 95% CI =1.10-1.33, P &lt; 0.001) with periodontitis were predisposed to severe osteoarthritis that led to total knee/hip replacement. In addition, periodontitis patients were more likely to have a history of osteoarthritis (OR = 1.11, 95% CI = 1.06 - 1.17, P &lt; 0.001). Conclusion: These findings suggest a bidirectional relationship between osteoarthritis and periodontitis. Patients with periodontitis presented with a higher risk of osteoarthritis, including severe osteoarthritis that led to total knee/hip replacement. Likewise, periodontitis was more likely to develop following osteoarthritis. References: [1]Wang Q, Rozelle AL, Lepus CM, et al. Identification of a central role for complement in osteoarthritis. Nat Med 2011;17:1674-9. Temoin S, Chakaki A, Askari A, et al. [2]Identification of oral bacterial DNA in synovial fluid of patients with arthritis with native and failed prosthetic joints. J Clin Rheumatol 2012;18:117-21. Disclosure of Interests: None declared
Composite of Relevant Endpoints for Sjögren's Syndrome (CRESS): development and validation of a novel outcome measure
Authors: Suzanne Arends, Liseth de Wolff, Jolien F van Nimwegen, Gwenny M P J Verstappen, Jelle Vehof, Michele Bombardieri, Simon J Bowman, Elena Pontarini, Alan N Baer, Marleen Nys, Jacques-Eric Gottenberg, Renaud Felten, Neelanjana Ray, Arjan Vissink, Frans G M Kroese, Hendrika Bootsma
Journal: The Lancet Rheumatology (2021)
Venous overload choroidopathy: A hypothetical framework for central serous chorioretinopathy and allied disorders
Authors: Richard F. Spaide, Chui Ming Gemmy Cheung, Hidetaka Matsumoto, Shoji Kishi, Camiel J.F. Boon, Elon H.C. van Dijk, Martine Mauget-Faysse, Francine Behar-Cohen, M. Elizabeth Hartnett, Sobha Sivaprasad, Tomohiro Iida, David M. Brown, Jay Chhablani, Peter M. Maloca
Journal: Progress in Retinal and Eye Research (2021)

In central serous chorioretinopathy (CSC), the macula is detached because of fluid leakage at the level of the retinal pigment epithelium. The fluid appears to originate from choroidal vascular hyperpermeability, but the etiology for the fluid is controversial. The choroidal vascular findings as elucidated by recent optical coherence tomography (OCT) and wide-field indocyanine green (ICG) angiographic evaluation show eyes with CSC have many of the same venous patterns that are found in eyes following occlusion of the vortex veins or carotid cavernous sinus fistulas (CCSF). The eyes show delayed choroidal filling, dilated veins, intervortex venous anastomoses, and choroidal vascular hyperpermeability. While patients with occlusion of the vortex veins or CCSF have extraocular abnormalities accounting for the venous outflow problems, eyes with CSC appear to have venous outflow abnormalities as an intrinsic phenomenon. Control of venous outflow from the eye involves a Starling resistor effect, which appears to be abnormal in CSC. Similar choroidal vascular abnormalities have been found in peripapillary pachychoroid syndrome. However, peripapillary pachychoroid syndrome has intervortex venous anastomoses located in the peripapillary region while in CSC these are seen to be located in the macular region. Spaceflight associated neuro-ocular syndrome appears to share many of the pathophysiologic problems of abnormal venous outflow from the choroid along with a host of associated abnormalities. These diseases vary according to their underlying etiologies but are linked by the venous decompensation in the choroid that leads to significant vision loss. Choroidal venous overload provides a unifying concept and theory for an improved understanding of the pathophysiology and classification of a group of diseases to a greater extent than previous proposals.
AB0266 METHOTREXATE AND CARDIOVASCULAR RISK IN RHEUMATIC DISEASES:A COMPREHENSIVE REVIEW
Authors: F. Verhoeven, C. Prati, M. Chouk, C. Demougeot, D. Wendling
Journal: Annals of the Rheumatic Diseases (2021)

Background: The management of inflammatory rheumatic disease has evolved in the last decade with the importance of the management of comorbidities. Methotrexate is the cornerstone of inflammatory rheumatic disease management, but its cardiovascular effects are still poorly understood Objectives: To assess the cardiovascular impact of methotrexate in inflammatory rheumatic disease. Methods: A systematic review of the literature, following the prisma recommandations, was performed on the PubMed and Embase databases with the following keywords: (“Methotrexate”) AND (“cardiovascular”). We included papers written in English and including patients older than 18 years. Results: 570 references were identified and, 36 articles were kept for analysis. The mechanism of action of methotrexate lies mainly on the antagonism of purines. It reduces systemic inflammation, oxidative stress. In Rheumatoid arthritis, the use of methotrexate was associated with a decreased incidence of high blood pressure, an improvement of the lipid profile and of the insulin resistance. Major adverse cardiovascular events were decreased with methotrexate. The effects of methotrexate on the endothelial function were more controversial and available data did not argue for a direct vascular effect of MTX in RA. In psoriatic arthritis, evidences were more scarce. A meta-analysis showed that methotrexate was associated with a reduction of cardiovascular events in patients with psoriatic arththritis. In psoriatic arthritis, methotrexate did not improve the endothelial function. In plaque psoriasis, available data were rare. The use of methotrexate in this condition was not associated with a reduction of cardiovascular events. Nevertheless, a decrease in circulating VCAM-1 and in E selectin levels was described with the use of methotrexate. In HIV infection, a model of pro inflammatory state, the use of methotrexate did not change the endothelial function and thus the cardiovascular events. Finally, in general population, the use of methotrexate did not decrease the occurrence of cardiovascular events after a myocardial infarction. Conclusion: The cardiovascular effects of methotrexate are poorly understood at this time. Nevertheless, it seems clear that methotrexate can reduce the occurrence of cardiovascular events in inflammatory disease. The mechanisms explaining this good issue are poorly understood, but it seems possible that the essential effect of methotrexate lies in the reduction of the inflammatory syndrome without a direct vascular impact. Disclosure of Interests: None declared
The Role of Oxidative Stress in Chemical Carcinogenesis
Authors: James E. Klaunig, Yong Xu, Jason S. Isenberg, Stephen Bachowski, Kyle L. Kolaja, Jiazhong Jiang, Donald E. Stevenson, Earl F. Walborg
Journal: Environmental Health Perspectives (1998)

Oxidative stress results when the balance between the production of reactive oxygen species (ROS) overrides the antioxidant capability of the target cell; oxidative damage from the interaction of reactive oxygen with critical cellular macromolecules may occur.ROS may interact with and modify cellular protein, lipid, and DNA, which results in altered target cell function.The accumulation of oxidative damage has been implicated in both acute and chronic cell injury including possible participation in the formation of cancer.Acute oxidative injury may produce selective cell death and a compensatory increase in cell proliferation.This stimulus may result in the formation of newly initiated preneoplastic cells and/or enhance the selective clonal expansion of latent initiated preneoplastic cells.Similarly, sublethal acute oxidative injury may produce unrepaired DNA damage and result in the formation of new mutations and, potentially, new initiated cells.In contrast, sustained chronic oxidative injury may lead to a nonlethal modification of normal cellular growth control mechanisms.Cellular oxidative stress can modify intercellular communication, protein kinase activity, membrane structure and function, and gene expression, and result in modulation of cell growth.We examined the role of oxidative stress as a possible mechanism by which nongenotoxic carcinogens may function.In studies with the selective mouse liver carcinogen dieldrin, a species-specific and dose-dependent decrease in liver antioxidant concentrations with a concomitant increase in ROS formation and oxidative damage was seen.This increase in oxidative stress correlated with an increase in hepatocyte DNA synthesis.Antioxidant supplementation prevented the dieldrin-induced cellular changes.Our findings suggest that the effect of nongenotoxic carcinogens (if they function through oxidative mechanisms) may be amplified in rodents but not in primates because of rodents' greater sensitivity to ROS.These results and findings reported by others support a potential role for oxidative-induced injury in the cancer process specifically during the promotion stage.
Sustainability of neutralising antibodies induced by bivalent or quadrivalent HPV vaccines and correlation with efficacy: a combined follow-up analysis of data from two randomised, double-blind, multicentre, phase 3 trials
Authors: Filipe Colaço Mariz, Penelope Gray, Noemi Bender, Tiina Eriksson, Hanna Kann, Dan Apter, Jorma Paavonen, Emma Pajunen, Kristina M Prager, Peter Sehr, Heljä-Marja Surcel, Tim Waterboer, Martin Müller, Michael Pawlita, Matti Lehtinen
Journal: The Lancet Infectious Diseases (2021)
Treatment of Glucagonoma-Related Necrolytic Migratory Erythema With Peptide Receptor Radionuclide Therapy
Authors: Mehmet Emin Mavi, Murat Tuncel
Journal: Clinical Nuclear Medicine (2021)

Glucagonomas are rare types of pancreatic neuroendocrine tumors. They may present with a clinical entity called glucagonoma syndrome, which includes necrolytic migratory erythema as a skin component. Here we present a 26-year-old woman experiencing ongoing skin lesions, excessive weight loss, and nausea. She was diagnosed with metastatic glucagonoma. Her 68Ga-DOTATATE PET/CT showed increased uptake at the primary pancreatic lesion and hepatic metastases. She received 2 cycles of peptide receptor radionuclide therapy and had a partial response with a near-complete regression of her skin lesions.
POS0704 LONG-TERM CLINICAL OUTCOMES OF PATIENTS WITH LUPUS NEPHRITIS TREATED WITH AN INTENSIFIED B-CELL DEPLETION PROTOCOL: A PROSPECTIVE STUDY
Authors: D. Roccatello, S. Sciascia, C. Naretto, M. Alpa, R. Fenoglio, M. Ferro, G. Quattrocchio, E. Rubini, E. Rahbari, D. Rossi
Journal: Annals of the Rheumatic Diseases (2021)

Background: B cells play a key role In the pathogenesis of Lupus Nephritis (LN). Objectives: we aim to investigate the safety and efficacy of an intensified B-cell depletion induction therapy (IBCDT)without immunosuppressive maintenance regimen compared to standard of care in biopsy-proven LN. Methods: Thirty patients were administered an IBCDT (4 weekly Rituximab 375mg/m2 and 2more doses after 1&amp;2 months;2 infusions of 10 mg/kg cyclophosphamide (CYC),3 methylprednisolone pulses), followed by oral prednisone (tapered to 5 mg/day by the 3rd month). No immunosuppressive maintenance therapy was given. Thirty patients matched for LN class and age were selected as controls: 20 received 3 methylprednisolone pulses days followed by oral prednisone and mycophenolate mofetil (MMF) 2-3 g/day, while 10 were given the Euro Lupus CYC. Results: At 12 months, complete renal remission was observed in 93% of patients on IBCDT, in 62.7% on MMF, and in 75% on CYC (p=0,03); the dose of oral prednisone was lower in the IBCDT group (mean±SD 2.9±5.0mg/dl) than MMF (10.5±8.0 mg/day,p&lt;0.01) or CYC group (7.5±9.0mg/day,p&lt;0.01). Mean follow-up after treatment was 44.5 months (IQR 36–120months), 48.6 months (IQR36–120months), and 45.3 (IQR36–120months) for IBCDT, MMF and CYC, respectively. At their last follow-up visit, we observed no significant differences in proteinuria and serum creatinine, nor in the frequency of new flares among the three groups. Conclusion: In biopsy proven LN, the IBCDT without further immunosuppressive maintenance therapy was shown to be as effective as conventional regimen of MMF or CYC followed by a 3-year maintenance MMF regimen. Moreover, the use of IBCDT was associated with a marked reduction of glucocorticoid cumulative dose. Disclosure of Interests: None declared
Type 1 Brugada Pattern Is Associated With Echocardiography-Detected Delayed Right Ventricular Outflow Tract Contraction
Authors: Filippo Trevisan, Matteo Bertini, Cristina Balla, Gabriele Pestelli, Andrea Luisi, Vittorio Smarrazzo, Marianna Farnè, Alessandra Ferlini, Francesca Gualandi, Donato Mele
Journal: Journal of the American College of Cardiology (2021)
Bone-targeted pH-responsive cerium nanoparticles for anabolic therapy in osteoporosis
Authors: Ce Dou, Jianmei Li, Jian He, Fei Luo, Tao Yu, Qijie Dai, Yueqi Chen, Jianzhong Xu, Xiaochao Yang, Shiwu Dong
Journal: Bioactive Materials (2021)

Antiresorptive drugs are widely used for treatment of osteoporosis and cancer bone metastasis, which function mainly through an overall inhibition of osteoclast. However, not all osteoclasts are "bone eaters"; preosteoclasts (pOCs) play anabolic roles in bone formation and angiogenesis through coupling with osteoblasts and secreting platelet derived growth factor-BB (PDGF-BB). In this study, a bone-targeted pH-responsive nanomaterial was designed for selectively eliminating mature osteoclasts (mOCs) without affecting pOCs. Biocompatible cerium nano-system (CNS) was guided to the acidic extracellular microenvironment created by mOCs and gained oxidative enzymatic activity. Oxidative CNS decreased the viability of mOCs through accumulating intracellular reactive oxygen species and enhancing calcium oscillation. Non-acid secreting anabolic pOCs were thus preserved and kept producing PDGF-BB, which lead to mesenchymal stem cell osteogenesis and endothelial progenitor cell angiogenesis via PI3K-Akt activated focal adhesion kinase. In treating osteoporotic ovariectomized mice, CNS showed better protective effects compare with the current first line antiresorptive drug due to the better anabolic effects marked by higher level of bone formation and vascularization. We provided a novel anabolic therapeutic strategy in treating bone disorders with excessive bone resorption.
Ventral pallidum DRD3 potentiates a pallido-habenular circuit driving accumbal dopamine release and cocaine seeking
Authors: Horia Pribiag, Sora Shin, Eric Hou-Jen Wang, Fangmiao Sun, Paul Datta, Alexander Okamoto, Hayden Guss, Akanksha Jain, Xiao-Yun Wang, Bruna De Freitas, Patrick Honma, Stefan Pate, Varoth Lilascharoen, Yulong Li, Byung Kook Lim
Journal: Neuron (2021)

Drugs of abuse induce persistent remodeling of reward circuit function, a process thought to underlie the emergence of drug craving and relapse to drug use. However, how circuit-specific, drug-induced molecular and cellular plasticity can have distributed effects on the mesolimbic dopamine reward system to facilitate relapse to drug use is not fully elucidated. Here, we demonstrate that dopamine receptor D3 (DRD3)-dependent plasticity in the ventral pallidum (VP) drives potentiation of dopamine release in the nucleus accumbens during relapse to cocaine seeking after abstinence. We show that two distinct VP DRD3+ neuronal populations projecting to either the lateral habenula (LHb) or the ventral tegmental area (VTA) display different patterns of activity during drug seeking following abstinence from cocaine self-administration and that selective suppression of elevated activity or DRD3 signaling in the LHb-projecting population reduces drug seeking. Together, our results uncover how circuit-specific DRD3-mediated plasticity contributes to the process of drug relapse.
Lung Cancer in Singapore
Authors: Yvonne L.E. Ang, Puey Ling Chia, Kevin L.M. Chua, Anantham Devanand, Cheng Nang Leong, Charlene J.Y. Liew, Boon Hean Ong, Jens Samol, Ju Ee Seet, John K.C. Tam, Daniel S.W. Tan, Lynette L.S. Teo, Ross A. Soo
Journal: Journal of Thoracic Oncology (2021)
AB0066 MECHANISMS OF TOTAL SAPONINS OF PANAX JAPONICUS MITIGATES COLLAGEN-INDUCED ARTHRITIS
Authors: Z. Feng, X. Guo, J. Ji, X. Hou, Y. Luo, X. Fu
Journal: Annals of the Rheumatic Diseases (2021)

Background: Total saponins of Panax japonicus (TSPJ) are extracted from Panax japonicus (T.Nees) C.A.Mey and have achieved a good therapeutic effect in the treatment of rheumatoid arthritis (RA). Unfortunately, the mechanism of TSPJ acting on RA is not clear. Objectives: To investigate the potential mechanisms and key targets of TSPJ on RA. Methods: The raw data were downloaded from the Gene Expression Omnibus (GEO) database, and the RStudio3.6.1 software was used to identify differentially expressed genes (DEGs). The potential targets of active compounds from TSPJ were predicted by the Pharmmapper and SwissTargetPrediction databases. Based on the overlapping genes, we used Cytoscape 3.7.2 software to construct a protein-protein interactions (PPI) network and to determine the mechanisms of the treatment by Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Collagen-induced arthritis (CIA) model was established and treated with different doses of TSPJ. Arthritis index (AI) and histology score were used to evaluate the symptoms of CIA. The levels of vascular endothelial growth factor (VEGF), hypoxia-inducible factor 1 (HIF-1), IL-1β, and IL-17A tested by enzyme linked immunosorbent assay and real time-quantitative Polymerase Chain Reaction. Results: A total of 2670 DEGs and 371 TSPJ targets were obtained, including 52 overlapping genes. 41 genes had protein interactions that are used to build the PPI network. The results of the KEGG enrichment analysis included VEGF and HIF-1 signaling pathway. Seven negative correlation genes and 16 positive correlation genes were obtained by correlational analysis of DEGs in VEGF and HIF-1 signaling pathway. SRC proto-oncogene, nonreceptor tyrosine kinase (SRC), and the signal transducer and the activator of transcription 3 (STAT 3) had a higher value of degree in PPI and showed a significant correlation in the pathways; they were regarded as key targets. Compared with the CIA model group, TSPJ significantly decreased the AI and histology scores. Moreover, the expression of VEGF-A, HIF-1α, IL-1β, and IL-17A in serum or spleens significantly reduced in a dose-dependent. Conclusion: Present study show that SRC and STAT 3 may be the key targets of TSPJ acting on the VEGF and HIF-1 signaling pathways, thus inhibiting angiogenesis and improving RA. Disclosure of Interests: None declared
We Are Not Immune: Racial and Ethnic Disparities in Autoimmune Liver Diseases
Authors: Brian T. Lee, Michele M. Tana, Jeffrey A. Kahn, Lily Dara
Journal: Hepatology (2021)

Autoimmune liver diseases are attributed to a complex interplay of biologic, acquired, and environmental factors. Increased prevalence, later stage at presentation, worse response to standard therapy, and transplant‐related disparities have all been reported in racial and ethnic minorities such as Black and Latinx patients with autoimmune liver diseases. While biology and inherited genetic predispositions may partly explain these disparities, definitive and universal genetic variations underlying these differences in outcomes have not been defined. Nonetheless, socioeconomic status, access to health care, environmental and societal factors, and implicit provider bias can all contribute to poor patient outcomes. There remains an unmet need to understand and mitigate the factors contributing to health inequity in autoimmune liver diseases. In this review, we summarize the data on racial and ethnic disparities in presentation, treatment response, and outcomes pertaining to autoimmune liver diseases in minority populations, on the premise that understanding disparities is the first step toward reaching health equity.
Five-year survival after an acute episode of decompensated pulmonary arterial hypertension in the modern management era of right heart failure
Authors: Laurent Savale, Constance Vuillard, Jérémie Pichon, Athénaïs Boucly, Anne Roche, Mitja Jevnikar, Nathan Ebstein, Xavier Jaïs, Jérôme Le Pavec, David Montani, Olaf Mercier, Olivier Sitbon, Elie Fadel, Marc Humbert
Journal: European Respiratory Journal (2021)

<b>Novel medical, instrumental and surgical management of right heart failure translate to improvements in long-term survival of the youngest patients with acute decompensated PAH</b>https://bit.ly/34CyJLF
Abstract 16167: Assessment of Cardiac Rejection Grade via Machine Learning Derived Features From Digital Biopsy Images
Authors: Sara ArabYarmohammadi, Andrew Janowczyk, Eliot G Peyster, Sepideh Azarianpour, Priti Lal, Michael D. Feldman, Kenneth Margulies, Anant Madabhushi
Journal: Circulation (2019)

Introduction: Cardiac allograft rejection is a serious concern, occurring in 30-40% of patients in the first-year post-transplant and increase risk of graft failure. The international society for h...