tbuckley/cabot-search huggingface dataset:
Retraction and Replacement of: Effect of Adding Ticagrelor to Standard Aspirin on Saphenous Vein Graft Patency in Patients Undergoing Coronary Artery Bypass Grafting (POPular CABG): A Randomized, Double-Blind, Placebo-Controlled Trial
Journal: Circulation (2021)

The authors contacted Circulation to identify the errors that occurred at within the article.Specifically: • The error concerns the use of an incorrect randomization code list for analyzing the data of the patients of one participating site (the St Antonius Hospital) after completion of the study.In all patients, including those in the St Antonius Hospital, randomization to the treatment groups was performed correctly.However, a wrong second randomization list for the St Antonius Hospital alone was used for the analysis.This randomization code list was erroneously generated 2 years after the start of the study, when code lists were generated for three new participating centers.We regret these errors as well as the confusion caused to Circulation and its readers.All parts of the article that were affected by the error (abstract, methods, results, discussion, Table 1,Table 2,Table 3,Figure 1, Figure 2, as well as the Table III-VII and Figure II in the Data Supplement) have been corrected and replaced online.
Utility of optical see-through head mounted displays in augmented reality-assisted surgery: A systematic review
Authors: Manuel Birlo, P.J. Eddie Edwards, Matthew Clarkson, Danail Stoyanov
Journal: Medical Image Analysis (2022)

This article presents a systematic review of optical see-through head mounted display (OST-HMD) usage in augmented reality (AR) surgery applications from 2013 to 2020. Articles were categorised by: OST-HMD device, surgical speciality, surgical application context, visualisation content, experimental design and evaluation, accuracy and human factors of human-computer interaction. 91 articles fulfilled all inclusion criteria. Some clear trends emerge. The Microsoft HoloLens increasingly dominates the field, with orthopaedic surgery being the most popular application (28.6\%). By far the most common surgical context is surgical guidance (n=58) and segmented preoperative models dominate visualisation (n = 40). Experiments mainly involve phantoms (n = 43) or system setup (n = 21), with patient case studies ranking third (n = 19), reflecting the comparative infancy of the field. Experiments cover issues from registration to perception with very different accuracy results. Human factors emerge as significant to OST-HMD utility. Some factors are addressed by the systems proposed, such as attention shift away from the surgical site and mental mapping of 2D images to 3D patient anatomy. Other persistent human factors remain or are caused by OST-HMD solutions, including ease of use, comfort and spatial perception issues. The significant upward trend in published articles is clear, but such devices are not yet established in the operating room and clinical studies showing benefit are lacking. A focused effort addressing technical registration and perceptual factors in the lab coupled with design that incorporates human factors considerations to solve clear clinical problems should ensure that the significant current research efforts will succeed.
Predictors of stent and stent-edge restenosis after Sr-90 radiation in the START trial Alexandra J. Lansky, Kartik Desai, Costantino Costantini-Ortiz, Mohan Suntharalingam, Ian Crocker, Kalon Ho, Larry S. Dean, John Lasala, Mark Reisman, Richard E. Kuntz, Raoul Bonan, Martin B. Leon. Cardiovascular Research Foundation, New York, NY, Lenox Hill Heart &amp; Vascular Institute, New York, NY
Journal: Journal of the American College of Cardiology (2001)
Comparative Effectiveness of Sodium-Glucose Cotransporter 2 Inhibitors vs Sulfonylureas in Patients With Type 2 Diabetes—Reply
Authors: Ziyad Al-Aly, Yan Xie
Journal: JAMA Internal Medicine (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
COMMERCIAL BIAS AND SCIENTIFIC EXACTNESS.
Journal: JAMA (1907)

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Deaths
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Silver Stools
Authors: Ying Ying T. Ong
Journal: JAMA (1979)

A STOOL specimen was sent to the laboratory with a request for a heavymetal screen. On examination, a metallic silver sheen was noted (Figure). The test for occult blood was positive, and the test for bile was negative. <h3>Report of a Case</h3> A 78-year-old woman was admitted to the hospital because of jaundice, weight loss, and dehydration. Physical examination showed she was cachectic and deeply jaundiced with icteric scleras. No abdominal masses were palpated. Rectal examination showed 4+ guaiac-positive stools. Pertinent laboratory findings included the following: hemoglobin, 12 g/dL; hematocrit, 34.7%; total bilirubin, 10 mg/dL; direct bilirubin, 7.3 mg/dL; SGOT, 67 IU/L; and alkaline phosphatase, 668 IU/L. Abdominal ultrasonography showed massive dilation of the common duct, an obstruction presumably caused by a neoplasm in the head of the pancreas. Percutaneous transhepatic cholangiography showed complete obstruction of the distal common bile duct, characterized by tapered, slightly asymmetric narrowing consistent with compression
ABSORPTION OF VITAMIN B12
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ensemble voting decreases false positives in AI second-observer reads for detecting colorectal cancer.
Authors: Brandon Salinel, Matthew Grudza, Sarah Zeien, Matthew Murphy, Jake Adkins, Corey Jensen, Curt Bay, Vikram Kodibagkar, Phillip Koo, Tomislav Dragovich, Michael A. Choti, Madappa N. Kundranda, Hongzhi Wang, Tanveer Syeda-Mahmood, John Chang
Journal: Journal of Clinical Oncology (2022)

141 Background: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths, and survival can be improved if early, suspect imaging features on CT of the abdomen and pelvis (CTAP) can be routinely identified. At present, up to 40% of these features are undiagnosed on routine CTAP, but this can be improved with a second observer. In this study, we developed a deep ensemble learning method for detecting CRC on CTAP to determine if increasing agreement between ensemble models can decrease the false positives detected by artificial intelligence (AI) second-observer. Methods: 2D U-Net convolutional neural network (CNN) containing 31 million trainable parameters was trained with 58 CRC CT images from Banner MD Anderson (AZ) and MD Anderson Cancer Center (TX) (51 used for training and 7 for validation) and 59 normal CT scans from Banner MD Anderson Cancer Center. 20 of the 25 CRC cases from public domain data (The Cancer Genome Atlas) were used to evaluate the performance of the models. The CRC was segmented using ITK-SNAP open-source software (v. 3.8). To apply the deep ensemble approach, five CNN models were trained independently with random initialization using the same U-Net architect and the same training data. Given a testing CT scan, each of the five trained CNN models was applied to produce tumor segmentation for the testing CT scan. The tumor segmentation results produced by the trained CNN models were then fused using a simple majority voting rule to produce consensus tumor segmentation results. The segmentation was analyzed by the percentage of correct detection, the number of false positives per case, and the Dice similarity coefficient (DSC). If parts of the CRC were flagged by AI, then it was considered correct. A detection was considered false positive if the marked lesion did not overlap with any CRC; contiguous false positives across different slices of CT image were considered a single false positive. DSC measures the quality of the segmentation by measuring the overlap between the ground-truth and AI detected lesion. Results: Our results showed that increasing the agreement between the 5 models dramatically decreases the number of false positives per CT at the expense of slight decrease in accuracy and DSC. This is described in the table. Conclusions: Our results show that AI-based second observer can potentially detect CRC on routine CTAP. Although the initial result yields high false positives per case, ensemble voting is an effective method for decreasing the false positives with a slight decrease in accuracy. This technique can be further improved for eventual clinical application.[Table: see text]
Predictors of heart failure after incident myocardial infarction: Have they changed in the reperfusion Era? A population-based study in Omsted County, MN Jens P. Hellermann, Steven J. Jacobsen, Barbara P. Yawn, Susan Weston, Margaret M. Redfield, Richard J. Rodeheffer, Guy S. Reeder, Veronique L. Roger. Mayo Clinic, Rochester, MN, Olmsted Medical Center, Rochester, MN
Journal: Journal of the American College of Cardiology (2001)
Genomic landscape of hyperleukocytic acute myeloid leukemia
Authors: Laetitia Largeaud, Sarah Bertoli, Emilie Bérard, Suzanne Tavitian, Muriel Picard, Stéphanie Dufrechou, Naïs Prade, François Vergez, Jean Baptiste Rieu, Isabelle Luquet, Audrey Sarry, Françoise Huguet, Jean Ruiz, Véronique De Mas, Eric Delabesse, Christian Récher
Journal: Blood Cancer Journal (2022)
Efficacy of ertapenem, gentamicin, fosfomycin, and ceftriaxone for the treatment of anogenital gonorrhoea (NABOGO): a randomised, non-inferiority trial
Authors: Henry J C de Vries, Myrthe de Laat, Vita W Jongen, Titia Heijman, Carolien M Wind, Anders Boyd, Jolinda de Korne-Elenbaas, Alje P van Dam, Maarten F Schim van der Loeff, Sylvia Bruisten, Elske Hoornenborg, Mirjam Knol, Ron A.A. Mathôt, Jan M. Prins
Journal: The Lancet Infectious Diseases (2022)
An Increase in Adolescent Cannabis Vaping Is Reported
Authors: Anita Slomski
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pseudonormalized doppler total ejection isovolume (TEI) index in patients with severe right ventricular infarction Shiro Yoshifuku, Yutaka Otsuji, Kunitsugu Takasaki, Toshinori Yuasa, Eiji Kuwahara, Kouichi Toyonaga, Souki Lee, Hitoshi Toda, Toshiro Kumanohoso, Hitoshi Nakashima, Tatsuru Matsuoka, Shinichi Minagoe, Chuwa Tei. Kagoshima University, Kagoshima, Japan
Journal: Journal of the American College of Cardiology (2001)
Evaluation of N-terminal pro-brain natriuretic peptide as marker of impaired left ventricular function after myocardial infarction Andreas Luchner, Christian Hengstenberg, Hannelore Loewel, Juergen Trawinski, Matthias Baumann, Heribert Schunkert, Guenter A. J. Riegger, Stephan R. Holmer. Klinik Innere Med. II, Regensburg, Germany, Roche Integrated Health Care Solutions, Basel, Switzerland
Journal: Journal of the American College of Cardiology (2001)
Books, Journals, New Media Received
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Serum erythropoietin levels in 696 patients investigated for erythrocytosis with <scp><i>JAK2</i></scp> mutation analysis
Authors: Benjamin Chin‐Yee, Ian Cheong, Maxim Matyashin, Alejandro Lazo‐Langner, Ian Chin‐Yee, Vipin Bhayana, Pratibha Bhai, Hanxin Lin, Bekim Sadikovic, Cyrus C. Hsia
Journal: American Journal of Hematology (2022)
Associations Between Glycemic Traits and Colorectal Cancer: A Mendelian Randomization Analysis
Authors: Neil Murphy, Mingyang Song, Nikos Papadimitriou, Robert Carreras-Torres, Claudia Langenberg, Richard M Martin, Konstantinos K Tsilidis, Inês Barroso, Ji Chen, Timothy M Frayling, Caroline J Bull, Emma E Vincent, Michelle Cotterchio, Stephen B Gruber, Rish K Pai, Polly A Newcomb, Aurora Perez-Cornago, Franzel J B van Duijnhoven, Bethany Van Guelpen, Pavel Vodicka, Alicja Wolk, Anna H Wu, Ulrike Peters, Andrew T Chan, Marc J Gunter
Journal: JNCI Journal of the National Cancer Institute (2022)

Glycemic traits-such as hyperinsulinemia, hyperglycemia, and type 2 diabetes-have been associated with higher colorectal cancer risk in observational studies; however, causality of these associations is uncertain. We used Mendelian randomization (MR) to estimate the causal effects of fasting insulin, 2-hour glucose, fasting glucose, glycated hemoglobin (HbA1c), and type 2 diabetes with colorectal cancer.
Landmark analysis of overall survival (OS) by objective response (OR) in previously treated patients (pts) with advanced hepatocellular carcinoma (aHCC): Post hoc analysis of the randomized, phase 3 KEYNOTE-240 study.
Authors: Andrew X. Zhu, Stéphane Cattan, Philippe Merle, Bruno Daniele, Stephen Lam Chan, Thomas Yau, Mohamed Bouattour, Ho Yeong Lim, Yee Chao, Jennifer J. Knox, Sadahisa Ogasawara, Marcelo Garrido, Ann-Lii Cheng, Julien Edeline, Richard S. Finn, Abby B. Siegel, Ahmadur Rahman, Chih-Chin Liu, Masatoshi Kudo
Journal: Journal of Clinical Oncology (2021)

e16122 Background: Studies have shown that OR is prognostic of OS in pts with HCC. KEYNOTE-224 (NCT02702414) evaluated pembrolizumab (pembro; anti–PD-1) in sorafenib (sora)-treated pts with aHCC and showed an ORR of 17% that was durable in responders receiving pembro, ultimately leading to FDA approval. In KEYNOTE-224, a landmark analysis showed that OR in pembro-treated pts was prognostic of longer OS. The KEYNOTE-240 (NCT02702401) study evaluated pembro + best supportive care (BSC) vs placebo (pbo) + BSC in sora-treated pts with aHCC. Although clinical benefit was observed in KEYNOTE-240 with pembro vs pbo, prespecified statistical significance criteria for OS and PFS were not met. This post hoc analysis of KEYNOTE-240 was performed to determine whether OR at landmark is prognostic of longer survival after landmark time. Methods: Eligible pts were aged ≥18 y, had confirmed aHCC, and experienced progression during or after sora treatment or intolerance to sora. Landmark analyses of OS according to OR at 6, 12, and 18 wk after randomization were performed on the pembro arm to evaluate the association between survival after the landmark with response achieved before the landmark. OR was assessed by blinded independent central review per RECIST v1.1. Responders at each landmark were defined as pts with any response assessment of CR or PR before the landmark date; all other pts were defined as nonresponders. HR and 95% CI for survival after the landmark were calculated from the Cox proportional hazards model using Efron method of tie handling, with responder status as a single covariate. Analysis was performed on the ITT population. Results: As of Jan 2, 2019, median time from randomization to data cutoff was 21.2 mo (range 13.4-30.4) for pembro. In the pembro arm, 51 pts (18.3%) had a best OR of CR or PR and 6 pts (4.4%) in the pbo arm had a best OR of PR (no CR) (excluded from landmark analyses). OS after landmark time was longer for responders than nonresponders at the wk 6, 12, and 18 time points (Table). The HR for OS after landmark time for responders vs nonresponders was 0.37 (95% CI 0.18-0.75), 0.39 (95% CI 0.23-0.66), and 0.37 (95% CI 0.21-0.63) at wk 6, 12, and 18, respectively. Conclusions: This post hoc analysis showed that pts with sora-treated aHCC who achieved OR by landmark time with pembro have longer OS after the landmark time, confirming the prognostic association between OR with pembro and OS observed in KEYNOTE-224. Clinical trial information: NCT02702401. [Table: see text]
Transparency during global health emergencies
Authors: None The Lancet Digital Health
Journal: The Lancet Digital Health (2020)

Medical research and publishing communities have been admonished for the lack of transparency in the reporting of COVID-19 data, exemplified by two recent retractions of COVID-19 papers published in The Lancet and The New England Journal of Medicine. These studies reported proprietary data from electronic health records allegedly obtained from hundreds of hospitals around the world by the company, Surgisphere. Post-publication analysis of these papers revealed multiple inconsistencies in the data and questions about the provenance of the data sources.
Erratum: Quantitative Microbial Risk Assessment for Airborne Transmission of SARS-CoV-2 via Breathing, Speaking, Singing, Coughing, and Sneezing
Authors: Jack Schijven, Lucie C. Vermeulen, Arno Swart, Adam Meijer, Erwin Duizer, Ana Maria de Roda Husman
Journal: Environmental Health Perspectives (2021)

Equation 9 contains the variable p i , which represents number of exposed persons.However, the text incorrectly defines n i as the number of exposed persons.The text in the last sentence of the second paragraph of the "Methods" section that reads "Numbers of expelled virus particles in a ventilated room" should instead read ". ..and p i is the number of exposed persons."The following text was added to the description of Equation 11 in the "Methods" section "Dose" for clarification: "The number N in Equation 11 represents the time-integrated numbers of expelled RNA copies of the virus and therefore has the dimension of time, and not the number of expelled RNA copies of the virus.Division of N as presented in Equation 11 by the exposure time T provides the numbers of expelled virus RNA copies."