tbuckley/cabot-search huggingface dataset:
Abstract 19102: Cardiac Specific Ablation of SAP97 Alters Normal Excitability of the Murine Heart
Authors: Hassan Musa, Lena Carleton, Ryan P O’Connell, Mario Gomez, Guadalupe Guerrero-Serna, Michelle Milstein, Todd Herron, Adam Stein, Justus M Anumonwo
Journal: Circulation (2013)

Synapse-associated protein 97 (SAP97) is a scaffolding protein and is the archetypical MAGUK. In vitro studies suggest that SAP97 regulates expression of cardiac Na and K channels, and may be important for cardiac excitation. OBJECTIVES: To generate a model for inducible, targeted SAP97 ablation, and to investigate arrhythmia susceptibility and the underlying cellular/molecular mechanisms. Methods: SAP97 targeted deletion was generated using the Cre-Lox system. Animals were subjected to biochemistry, electrophysiology, echo- and electrocardiographic analyses. Results: Western blot analyses demonstrated SAP97 ablation was specific to the myocardium. Test animals showed several ECG abnormalities; including changes in P waves, premature atrial contractions, and prolongations in ST and QT intervals. ST interval averaged (ms) 22.3±2.53 (heterozygote) compared to 15.9±0.98 (control; p=0.03). ST prolongation was more pronounced (34.8±2.22 ms) in homozygote than in heterozygote mice; p&lt; 0.001. Similarly, QT interval was much longer in homozygote than in heterozygote animals, both of which were longer than control values (p&lt;0.001; n=13-15 in each group). In isolated ventricular cells, action potential duration at 80% repolarization; (APD80) were significantly longer in test animals compared to controls. Thus, control APD80 (ms) was 11.6±2.38 versus 47.19±11.27 in heterozygote animals (p=0.012). APD prolongation was more severe in homozygote animals. Early after depolarizations were more prevalent in test mice, compared to control. Data in cells isolated from control and homozygote mouse hearts showed significant changes in INa, ITO and IK1 current densities following SAP97 ablation. Control densities of ITO and IK1 were (pA/pF) 43.68±3.91 (+60mV) and -18.13±0.95 (-120mV) and were 19.96±2.48 and -12.38±0.64 after SAP97 ablation. In contrast, INa density was upregulated, averaging (pA/pF) -32.52±4.60 (-50mV) in control and -47.53±4.47 after SAP97 ablation. Conclusion: SAP97 is important for normal functionality of cardiac ion channels in the murine myocardium, and its ablation predisposes to arrhythmogenicity. Our model of targeted SAP97 ablation is important for understanding the role of SAP97 in cardiac excitation.
Immunohistochemical analysis of transforming growth factor β3 expression in solitary morphoea profunda with histological membranocystic changes
Authors: T. Kawakami, Y. Soma, T. Baba, M. Mizoguchi, K. Matsuzaki, N. Kumagai
Journal: British Journal of Dermatology (2002)

Journal Article Immunohistochemical analysis of transforming growth factor β3 expression in solitary morphoea profunda with histological membranocystic changes Get access British Journal of Dermatology, Volume 146, Issue 1, 1 January 2002, Pages 171–173, https://doi.org/10.1046/j.1365-2133.2002.4513_7.x Published: 01 January 2002
Abstract 3729: High-Dose Atorvastatin Attenuates Cardiovascular Risk Prediction of the Metabolic Syndrome Components
Authors: Prakash Deedwania, Scott M Grundy, John J Kastelein, Andrei Breazna
Journal: Circulation (2007)

The relative predictive power of individual components of the metabolic syndrome (MS) likely differs before and after therapy. The current analysis investigates the impact of intensive lipid loweri...
Soundings: Sudan in winter
Authors: James Owen Drife
Journal: BMJ (2005)

The Khartoum Hilton, last month, was a comfortable pied-a-terre for an external examiner. Downstairs in the business centre I caught up on my emails. The Sunset Lounge had plenty of drinks, all non-alcoholic, and the lobby had a Christmas tree.

I felt surrounded by history. Along the Blue Nile was the palace where General Gordon died. Across the Nile itself were the Madhi's tomb and the Khalifa's house, now a museum, where a smiling guide showed me Kitchener's Gatling gun. Shock and awe, Victorian style. At Omdurman in 1898 the Anglo-Egyptians lost 43 dead, while the Mahdists' casualties were 27 000.

Incredibly, the conflict left no hard feelings but only mutual respect. The British built Gordon Memorial College in 1902 and the Kitchener Medical School in 1924. After independence in 1956 these became Khartoum University and its medical faculty, which now admits about 280 students annually.

Medical graduates do house jobs and military service, and then specialise. Young obstetricians may face spectacular pathology. I heard about a patient with a ruptured uterus who waited for days by the roadside for a lift to hospital. She survived. What right had I to examine these doctors, in English, at the end of their training?

My fellow examiners, from local centres, were keen to maintain standards. Many had done part of their training in the United Kingdom and spoke affectionately of their time there. As so often, I apologised for the loss of professorial power, which once facilitated overseas exchanges.

Was the trip worth while? For me, yes. The laughter and hospitality were wonderful. For Sudan? The nation got 26 more obstetricians and gynaecologists, most of whom, I gathered, would probably stay in Khartoum. Dispersing doctors around the country will have to await peace but hopes are high.

Although the hospital now has easy web access, personal contacts are prized. One professor described external examiners as “a straw connecting us to the world and letting us breathe.”

At dinner the vice chancellor said he had heard that UK consultants were retiring early. “They could do lots of good by spending short spells here. Fares and accommodation but no salary, I'm afraid.” I said I was sure they would enjoy it and I would pass his request on.
Tranylcypromine Isomers and Parkinson's Disease: New Aspects of an Old Drug
Authors: G P Reynolds, P Riederer, M Sandler
Journal: Journal of the Royal Society of Medicine (1981)

The tranylcypromine stereoisomers have been investigated in a series of comparative trials in Parkinson's disease and the results indicate that doses below 3 mg/day, of the (+)-isomer in particular, are effective as adjuvant antiparkinsonian therapy. Biochemical results, monitoring platelet monoamine oxidase (MAO) activity and plasma concentrations of drugs and phenylethylamine, an MAO substrate, showed such low doses of the (+)-isomer to inhibit MAO without inducing the hypertensive reaction sometimes observed at higher dosage. These findings, along with the observation of substantial pharmacokinetic differences between the two isomers are discussed, particularly in relation to reports on their efficacy in depressive illness.
Abstract 3200: Free Fatty Acid Infusion and Vascular Function in Obese African-Americans with the Metabolic Syndrome
Authors: Andres Palacio, Dawn Smiley, Gonzalo Robalino, Faiz A Cheema, Bobby V Khan, Guillermo E Umpierrez
Journal: Circulation (2006)

Background: Increased levels of free fatty acids (FFA) are thought to contribute to the pathogenesis of hypertension (HTN); however, the mechanisms are poorly understood. Accordingly, we evaluated ...
Abstract 9432: Superior Long-term Prognostic Impact of Angiotensin Converting Enzyme Inhibitors to Angiotensin II Receptor Blockers After ST-Elevation Myocardial Infarction
Authors: Masahiko Hara, Yasuhiko Sakata, Daisaku Nakatani, Shinichiro Suna, Masaya Usami, Sen Matsumoto, Masami Nishino, Hiroshi Sato, Tetsuhisa Kitamura, Shinsuke Nanto, Masatsugu Hori, Issei Komuro
Journal: Circulation (2013)

Background: Although international guidelines recommend angiotensin-converting enzyme inhibitor (ACEI) as the first-line therapy after ST-elevation myocardial infarction (STEMI), the prescription of angiotensin II receptor blockers (ARB) is surpassing that of ACEI worldwide. Here, we examined whether the long-term benefits of ARB are comparable with those of ACEI in post-STEMI patients in the real-world setting. Methods: We compared 5-year survival benefits of ACEI and ARB in 7,547 consecutive STEMI patients registered with the Osaka Acute Coronary Insufficiency study between 1998 and 2010. Study subjects were divided into 3 groups: patients treated with ACEI (n=3,794), ARB (n=1,786), or without either drug (n=1,967) at survival discharge. Results: A total of 545 deaths were recorded during a median follow-up period of 3.9 years after survival discharge. The prescription rate of ARB at discharge increased from 1998 to 2010, whereas that of ACEI decreased (p&lt;0.001). Cox regression analysis revealed that treatment with either ACEI or ARB at discharge was associated with reduced 5-year mortality (adjusted hazard ratio (HR) 0.67, 95% confidence interval (CI) 0.56-0.81, p&lt;0.001; and HR 0.76, 95% CI 0.60-0.96, p=0.021, respectively). However, Kaplan-Meier estimates and Cox regression analyses based on propensity score (PS) revealed that ACEI was associated with significantly better survival than ARB from 2 to 5 years after survival discharge (adjusted HR 0.57, 95% CI 0.40-0.81, p=0.002) despite comparable prognostic impacts for the first 2 years (adjusted HR 1.03, 95% CI 0.71-1.49, p=0.878). These findings were also confirmed in a PS-matched population. Conclusions: Although ACEI and ARB treatment showed comparable prognostic impacts in the first 2 years after STEMI onset, treatment with ACEI was associated with better survival from 2 to 5 years. Further investigations are warranted to confirm the results.
Clinical efficacy of treatment for head lice
Authors: M. Stallbaumer, J. Ibarra
Journal: BMJ (1995)

into question the concentration of efforts to prevent suicide on health care services.While supporting the need for good planning for patients' discharge, we believe that efforts should continue to identify other routes of intervention in the great majority of those dying by suicide, who have not been in contact with primary care or inpatient psychiatric services.Detailed examination of high risk groups, such as younger people and those in deprived communities,4 together with review of the scope for structural interventions, such as limiting the availability of popular methods of suicide,' may offer the greatest population benefits.
What is said may not convey what is intended
Authors: J. Lister
Journal: BMJ (1996)

Telling patients there is nothing wrong Randomised controlled trials are needed EDrroR,-It is still unclear from the literature whether investigative tests reassure patients with anxieties about the presence of serious disease.' 2 Ray Fitzpatrick discusses some of the possible reasons for this, including psychiatric morbidity, poor communication, and the "wild card effects" mentioned in the study by I G McDonald and colleagues.3Other psychological processes in patients are
Abstract P413: Do Methodological Issues Account for the Inconsistent Results Observed in Cohort Studies of Sodium Intake and Clinical Cardiovascular Disease Outcomes?
Authors: Laura K Cobb, Cheryl A Anderson, Paul Elliot, Jiang He, Frank B Hu, Joachim H Ix, Kiang Liu, Paul K Whelton, Mark Woodward, Lawrence J Appel
Journal: Circulation (2013)

Introduction: As sodium intake (Na) rises, so does blood pressure. However, the results of cohort studies that relate Na to cardiovascular disease (CVD) are inconsistent. We systematically reviewed the quality of cohort studies for methodological issues that could bias assessments of the relationship between Na and CVD. Hypothesis: Methodological limitations are common in cohort studies assessing the link between Na and CVD. Methods: We included all known articles that examined the association between Na and CVD or all-cause mortality, coronary heart disease, stroke or heart failure. We divided articles based on 1) type of study population, i.e. general population versus targeted samples at elevated risk of CVD and 2) method of Na assessment. We looked for the presence of random and systematic error in Na assessment, analytic issues such as under-adjustment, and potential for residual confounding and reverse causality. Results: We identified 26 studies with 31 independent samples. Of the samples, 13 found at least one direct association between Na and CVD, 10 at least one inverse or J-shaped association, and eight only null associations. 20 were from the general population and 11 from targeted groups. Urine collection was used to assess Na in 13 (24-hour collections in 11) and diet-based measures in 18. Overall, 81% of the 31 samples had a high potential for random errors in sodium assessment, eight of the 17 with sufficient information had systematic errors in Na assessment, 29% were conducted in targeted groups with high potential for reverse causality, and 52% were inadequately adjusted. Conclusions: Methodological issues are common in observational studies linking Na and CVD.
Long-term Oncologic Outcomes Following Robot-assisted Radical Cystectomy: Results from the International Robotic Cystectomy Consortium
Authors: Syed Johar Raza, Timothy Wilson, James O. Peabody, Peter Wiklund, Douglas S. Scherr, Ali Al-Daghmin, Shiva Dibaj, Muhammad Shamim Khan, Prokar Dasgupta, Alex Mottrie, Mani Menon, Bertram Yuh, Lee Richstone, Matthias Saar, Michael Stoeckle, Abolfazl Hosseini, Jihad Kaouk, James L. Mohler, Koon-Ho Rha, Gregory Wilding, Khurshid A. Guru
Journal: European Urology (2015)
Abstract P114: Association of Psychosocial Wtress with Incident Coronary Heart Disease and All-cause Mortality among Low and High Income Individuals in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study
Authors: Nicole Redmond, Joshua Richman, Christopher Gamboa, Michelle A Albert, Mario Sims, Raegan Durant, Stephen Glasser, Monika M Safford
Journal: Circulation (2013)

Introduction: Stress may increase risk for coronary heart disease (CHD) and death, especially for individuals living in poverty. Few prospective studies have examined the relationships between stress, CHD and mortality among minorities, who are more likely to be poor. We studied the association of perceived stress with incident CHD and mortality in a large biracial cohort. Methods: REGARDS includes 30,239 community-dwelling black and white participants age &gt;45 years recruited from 2003-07. Recruitment oversampled the Stroke Belt and Buckle and included residents of 48 states. Participants were telephoned every 6 months for CVD endpoints, with retrieval of medical records, death certificates, interviews with next-of-kin, and expert adjudication. CHD was defined as definite or probable myocardial infarction or CHD death. Stress was assessed using the 4-item Cohen’s Perceived Stress Scale (PSS). Among participants free of CHD at baseline, Cox models estimated hazard ratios for incident CHD and all-cause mortality through 12/31/2009, adjusting for socioedemographic, clinical, and behavioral CHD risk factors, and testing for interactions by race and income. Results: The analytic sample included 24,439 subjects with mean age 64.1 years (SD+9.3), with 58% women and 42% blacks. Over a mean follow-up of 4.2 (maximum 6.9) years, there were 659 incident acute CHD events and 1320 deaths. Analyses were stratified by income (Table) due to significant interactions with stress; no significant interactions were found by race. The highest quartile of stress was associated with higher risk for incident CHD among those with low income (HR 1.36, {95% CI 1.04, 1.78}) but not high income (HR 0.82, {95% CI 0.57, 1.16}). This relationship was slightly attenuated with full adjustment. Each increasing quartile of stress was associated with increasingly higher risk of death for those with low but not high income. Conclusion: Stress may confer greater risks of CHD and death for individuals with low but not high income.
Expression of Macrophage Inflammatory Protein-1 Receptors in Human CD34+ Hematopoietic Cells and Their Modulation by Tumor Necrosis Factor- and Interferon-γ
Authors: Jan Dürig, Erika A. de Wynter, Christoph Kasper, Michael A. Cross, James Chang, Nydia G. Testa, Clare M. Heyworth
Journal: Blood (1998)
Abstract 18039: Cardiac Catheterization in the Early Postoperative Period Following Congenital Cardiac Surgery
Authors: George T Nicholson, Alex Ehrlich, Dennis W Kim, Robert N Vincent, Michelle Glanville, Christopher J Petit
Journal: Circulation (2013)

Background: Early postoperative cardiac catheterization (EPOCC) is regarded as high-risk, particularly when patients are unstable or when interventions upon suture lines are anticipated. There are little data available demonstrating safety of EPOCC. Objective: The purpose of this study was to describe the safety of catheterizations performed in ≤ 30 days after congenital heart surgery. Methods/Results: All EPOCC performed within 30 days after congenital heart surgery between November 2004 and May 2013 were retrospectively reviewed. One-hundred and ninety-one patients, median age 0.4 years (range 0-18.5 years), weight 5.3 kg (range 2.2-98.5 kg) underwent EPOCC on median postoperative day 6 (range 0-30 days). One-hundred and twenty-seven catheterizations were diagnostic while 64 pts underwent a total of 89 interventional procedures. At time of EPOCC, 21 patients were receiving extracorporeal cardiopulmonary (ECMO) support. Among the 89 interventions were 64 dilation procedures, 60 of which were at surgical anastomotic areas. There was one procedural mortality due to tear during angioplasty. In addition, there were 4 major complications including need for ECMO support (n=2) and need for resuscitation (n=2). There were 42 deaths (21%) prior to hospital discharge. Interventional EPOCC was not associated with increased risk of mortality (p=0.87) as compared to those who only underwent a diagnostic catheterization. Binary logistic regression demonstrated that ECMO support at time of EPOCC (p=0.001), lower weight at EPOCC (p&lt;0.001), and younger age at EPOCC (p&lt;0.001) were associated with mortality. Conclusion: EPOCC is in most cases safe, even in small, critically ill children. Interventions, including angioplasty and stenting across suture lines, can be safely performed, though caution is essential. Interventional EPOCC is not associated with increased risk of mortality.
West Nile Virus Activity—New York and New Jersey, 2000
Authors: A. Novello, D. White, L. Kramer, C. Trimarchi, M. Eidson, D. Morse, P. Smith, W. Stone, J. Miller, M. Layton, W. Crans, F. Sorhage, E. Bresnitz
Journal: JAMA (2000)
Exposure to Endocrine-Disrupting Chemicals during Pregnancy and Weight at 7 Years of Age: A Multi-pollutant Approach
Authors: Keren Agay-Shay, David Martinez, Damaskini Valvi, Raquel Garcia-Esteban, Xavier Basagaña, Oliver Robinson, Maribel Casas, Jordi Sunyer, Martine Vrijheid
Journal: Environmental Health Perspectives (2015)

BackgroundPrenatal exposure to endocrine-disrupting chemicals (EDCs) may induce weight gain and obesity in children, but the obesogenic effects of mixtures have not been studied.ObjectiveWe evaluated the associations between pre- and perinatal biomarker concentrations of 27 EDCs and child weight status at 7 years of age.MethodsIn pregnant women enrolled in a Spanish birth cohort study between 2004 and 2006, we measured the concentrations of 10 phthalate metabolites, bisphenol A, cadmium, arsenic, and lead in two maternal pregnancy urine samples; 6 organochlorine compounds in maternal pregnancy serum; mercury in cord blood; and 6 polybrominated diphenyl ether congeners in colostrum. Among 470 children at 7 years, body mass index (BMI) z-scores were calculated, and overweight was defined as BMI &gt; 85th percentile. We estimated associations with EDCs in single-pollutant models and applied principal-component analysis (PCA) on the 27 pollutant concentrations.ResultsIn single-pollutant models, HCB (hexachlorobenzene), βHCH (β-hexachlorocyclohexane), and polychlorinated biphenyl (PCB) congeners 138 and 180 were associated with increased child BMI z-scores; and HCB, βHCH, PCB-138, and DDE (dichlorodiphenyldichloroethylene) with overweight risk. PCA generated four factors that accounted for 43.4% of the total variance. The organochlorine factor was positively associated with BMI z-scores and with overweight (adjusted RR, tertile 3 vs. 1: 2.59; 95% CI: 1.19, 5.63), and these associations were robust to adjustment for other EDCs. Exposure in the second tertile of the phthalate factor was inversely associated with overweight.ConclusionsPrenatal exposure to organochlorines was positively associated with overweight at age 7 years in our study population. Other EDCs exposures did not confound this association.CitationAgay-Shay K, Martinez D, Valvi D, Garcia-Esteban R, Basagaña X, Robinson O, Casas M, Sunyer J, Vrijheid M. 2015. Exposure to endocrine-disrupting chemicals during pregnancy and weight at 7 years of age: a multi-pollutant approach. Environ Health Perspect 123:1030–1037; http://dx.doi.org/10.1289/ehp.1409049
Abstract 3466: Hypertension Treatment and Control Among Patients Hospitalized with Heart Failure: An Analysis of Get With The Guidelines Heart Failure
Authors: Daniel T Lackland, Christopher P Cannon, Brent M Egan, Gregg Fonarow, Yanglin Yu, Adrian F Hernandez, Rose Marie Robertson, Daniel W Jones
Journal: Circulation (2007)

Background: Hypertension is a major factor associated with heart failure (HF).While effective blood pressure (BP) control is recommended in patients with HF, little is known regarding treatment and control rates in these patients. Methods: The analyses assessed HF patients from 195 hospitals participating in the GWTG-HF quality improvement program from January 2005 through September 2006. Patients with hypertension were assessed for number and type of hypertension treatment as well as BP control rates. Analyses were stratified by race-sex groups with multivariate logistic regression models using the generalized estimating equations methods assessed the factors associated with multiple treatment, type of therapy, and BP control levels. Results: Of 37,318 HF patients, 62.3% (23,257) had diagnosed hypertension. The majority (67.3%) of these high-risk individuals were treated with 3 or more hypertension drugs, which was significantly varied by race-sex groups. The use of ACEI (64.6%), beta blockers (79.9%), angiotensin receptor blockers (18.5%), diuretics (62.4%), loop diuretic (73.8%), and calcium channel blockers (13.3%) significantly varied by race-sex groups. BP control rates (&lt; 140/90 mm Hg) at discharge significantly varied by race-sex group (total 70.8%; white males (WM) 76.3%; white females (WF) 71.1%; black males (BM) 63.0%; and black females (BF) 62.9%). Significant factors associated with BP control at discharge included age, race-sex (WF vs. BF, WM vs. BF), atrial fibrillation, hyperlipidemia, coronary heart disease, ICD, pacemaker, history of MI, and not having one or more of the following co-morbid conditions: diabetes, peripheral vascular disease, CVA and renal disease. Control rates considering BP &lt; 130/80 mm Hg (52.3%) showed similar significant variation by race-sex group (WM 57.4%; WF 53.7%; BM 42.3%.; and BF 44.4%). Conclusions: The less than optimal blood pressure control levels and the gender/racial disparities support continued emphasis on hypertension treatment and control among patients with heart failure.
The Effect of Age on Outcomes of Coronary Artery Bypass Surgery Compared With Balloon Angioplasty or Bare-Metal Stent Implantation Among Patients With Multivessel Coronary Disease
Authors: Marcus Flather, June-Wha Rhee, Derek B. Boothroyd, Eric Boersma, Maria Mori Brooks, Didier Carrié, Tim C. Clayton, Nicholas Danchin, Christian W. Hamm, Whady A. Hueb, Spencer B. King, Stuart J. Pocock, Alfredo E. Rodriguez, Patrick Serruys, Ulrich Sigwart, Rodney H. Stables, Mark A. Hlatky
Journal: Journal of the American College of Cardiology (2012)