tbuckley/cabot-search huggingface dataset:
Aberrant translation regulated by METTL1/WDR4‐mediated tRNA N7‐methylguanosine modification drives head and neck squamous cell carcinoma progression
Authors: Jie Chen, Kang Li, Jianwen Chen, Xiaochen Wang, Rongsong Ling, Maosheng Cheng, Zhi Chen, Fangfang Chen, Qianting He, Shuai Li, Caihua Zhang, Yizhou Jiang, Qianming Chen, Anxun Wang, Demeng Chen
Journal: Cancer Communications (2022)

Cancer cells selectively promote the translation of oncogenic transcripts to stimulate cancer progression. Although growing evidence has revealed that tRNA modifications and related genes participate in this process, their roles in head and neck squamous cell carcinoma (HNSCC) remain largely uncharacterized. Here, we sought to investigate the function and mechanisms of the transfer RNA (tRNA) N7-methylguanosine (m7 G) modification in regulating the occurrence and development of HNSCC.Cell lost-of-function and gain-of-function assays, xenograft models, conditional knockout and knockin mouse models were used to study the physiological functions of tRNA m7 G modification in HNSCC tumorigenesis. tRNA modification and expression profiling, mRNA translation profiling and rescue assays were performed to uncover the underlying molecular mechanisms. Single-cell RNA sequencing (scRNA-seq) was conducted to explore the tumor microenvironment changes.The tRNA m7 G methyltransferase complex components Methyltransferase-like 1 (METTL1)/WD repeat domain 4 (WDR4) were upregulated in HNSCC and associated with a poor prognosis. Functionally, METTL1/WDR4 promoted HNSCC progression and metastasis in cell-based and transgenic mouse models. Mechanistically, ablation of METTL1 reduced the m7 G levels of 16 tRNAs, inhibiting the translation of a subset of oncogenic transcripts, including genes related to the phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling pathway. In addition, chemical modulators of the PI3K/Akt/mTOR signaling pathway reversed the effects of Mettl1 in mouse HNSCC. Furthermore, scRNA-seq results revealed that Mettl1 knockout in mouse tumor cells altered the immune landscape and cell-cell interaction between the tumor and stromal compartment.The tRNA m7 G methyltransferase METTL1 was found to promote the development and malignancy of HNSCC through regulating global mRNA translation, including the PI3K/AKT/mTOR signaling pathway, and found to alter immune landscape. METTL1 could be a promising treatment target for HNSCC patients.
A Textbook of Dietetics
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Development of the gut microbiota in healthy children in the first ten years of life: associations with internalizing and externalizing behavior
Authors: Yangwenshan Ou, Clara Belzer, Hauke Smidt, Carolina de Weerth
Journal: Gut Microbes (2022)

Increasing evidence indicates that psychopathological disorders are associated with the gut microbiota. However, data are largely lacking from long-term longitudinal birth cohorts, especially those comprising low-risk healthy individuals. Therefore, this study aims to describe gut microbiota development in healthy children from birth till age 10 years, as well as to investigate potential associations with internalizing and externalizing behavior.
Antimicrobial production by perifollicular dermal preadipocytes is essential to the pathophysiology of acne
Authors: Alan M. O’Neill, Marc C. Liggins, Jason S. Seidman, Tran H. Do, Fengwu Li, Kellen J. Cavagnero, Tatsuya Dokoshi, Joyce Y. Cheng, Faiza Shafiq, Tissa R. Hata, Johann E. Gudjonsson, Robert L. Modlin, Richard L. Gallo
Journal: Science Translational Medicine (2022)

Innate immune defense against deep tissue infection by Staphylococcus aureus is orchestrated by fibroblasts that become antimicrobial when triggered to differentiate into adipocytes. However, the role of this process in noninfectious human diseases is unknown. To investigate the potential role of adipogenesis by dermal fibroblasts in acne, a disorder triggered by Cutibacterium acnes , single-cell RNA sequencing was performed on human acne lesions and mouse skin challenged by C. acnes . A transcriptome consistent with adipogenesis was observed within specific fibroblast subsets from human acne and mouse skin lesions infected with C. acnes . Perifollicular dermal preadipocytes in human acne and mouse skin lesions showed colocalization of PREF1, an early marker of adipogenesis, and cathelicidin ( Camp ), an antimicrobial peptide. This capacity of C. acnes to specifically trigger production of cathelicidin in preadipocytes was dependent on TLR2. Treatment of wild-type mice with retinoic acid (RA) suppressed the capacity of C. acnes to form acne-like lesions, inhibited adipogenesis, and enhanced cathelicidin expression in preadipocytes, but lesions were unresponsive in Camp −/− mice, despite the anti-adipogenic action of RA. Analysis of inflamed skin of acne patients after retinoid treatment also showed enhanced induction of cathelicidin, a previously unknown beneficial effect of retinoids in difficult-to-treat acne. Overall, these data provide evidence that adipogenic fibroblasts are a critical component of the pathogenesis of acne and represent a potential target for therapy.
Nova et Vetera
Authors: F N POYNTER
Journal: BMJ (1954)

DICKENS, in presenting the annual report, said that the report embodied the principal results of the re- searches of no fewer than 29 independent research centres, each a team of from a few workers to more than 60 at the largest centre, as well as those of 26 individuals in charge of research grants and 15 holders of research fellowships.On the question of tobacco smoking and cancer of the lung the Campaign was actively promoting investigations.No conclusive results were yet available as to the presence of any known carcinogen in tobacco smoke, though it seemed that there was none of an activity comparable with coal tar.So far no suitable method had been devised for inducing lung cancer in animals.In spite of the urgency of this problem, the experimental work was, from its nature.bound to take many months.Research into methods of treatment of cancer, Professor Dickens went on, was proceeding hand in hand with those on causation.Surgery and radiation remained the accepted treatments for most cancers, and in the field of radiotherapy the opening of the new cobalt-60 beam therapy unit, the generous gift to the Campaign of a Canadian benefactor, Mr. J. W. McConnell, had now made available for research the very intense gamma rays produced by that source.After a reference to hormone therapy, he said that there were other new agents now being used in the treatment of certain types of malignant disease.These were the sub-
CONSERVATION OF THE MENSTRUAL FUNCTION
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Poor isometric neck extension strength as a risk factor for concussion in male professional Rugby Union players
Authors: Theo Farley, Ed Barry, Richard Sylvester, Akbar De Medici, Mathew G Wilson
Journal: British Journal of Sports Medicine (2022)

Concussion is one of the highest burden injuries within professional Rugby Union ('rugby') and comes with a high health and financial cost to players and teams. Limited evidence exists as to the existence of modifiable intrinsic risk factors for concussion, leaving athletes and clinicians with few options when developing prevention strategies.To investigate whether neck strength is significantly associated with concussion incidence in professional male rugby players.225 rugby players were assessed for neck strength at three time points throughout the 2018/2019 season using a method of isometric contraction. Associations with clinically diagnosed concussion injuries are presented as incidence rate ratios (IRRs) with 95% CIs.Thirty concussions occurred in 29 players during the study period; a rate of 13.7 concussions per 1000 hours played. Greater neck strength was observed at mid and end of season time points versus preseason across the study population. There was a significant association between extension strength and concussion; a 10% increase for extension strength was associated with a 13% reduction in concussion rate (adjusted IRR (95% CI) 0.87 (0.78 to 0.98). No other significant associations were observed between concussion incidence and any other unique neck strength range or composite score.Higher neck extension strength is associated with lower concussion rates in male rugby players. Neck strength is a modifiable intrinsic risk factor for concussion and may be an important component of a strength and conditioning regime.
Miscellanea Medica
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical News
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Flow cytometry for the assessment of blood tumour burden in cutaneous T‐cell lymphoma: towards a standardized approach
Authors: Maarten H. Vermeer, Helene Moins‐Teisserenc, Martine Bagot, Pietro Quaglino, Sean Whittaker
Journal: British Journal of Dermatology (2022)

Mycosis fungoides (MF) and Sézary syndrome (SS) are the best-studied subtypes of cutaneous T-cell lymphoma, a rare non-Hodgkin lymphoma that primarily presents in the skin but can also involve blood, lymph nodes and viscera. The role of blood involvement in the assessment and staging of MF and SS has evolved in recent years from being classed as simply 'present' or 'absent', with no impact on staging, to full analysis of abnormal peripheral blood T cells using flow cytometry (FC) to detect and quantify aberrant T-cell phenotypes and polymerase chain reaction (PCR) to characterize T-cell receptor gene rearrangements. These sensitive peripheral blood assessments are replacing manual Sézary cell counts and have become an important part of clinical workup in MF and SS, providing the potential for more accurate prognosis and appropriate management. However, although international recommendations now include guidelines for FC analysis of peripheral blood markers for staging purposes, many clinics only perform these analyses in patients with advanced-stage lymphoma, if at all, and there is still a need for standardized use of validated markers. Standardization of a single effective multiparameter FC panel would allow for accurate identification and quantification of blood tumour burden for diagnosis, staging, assessment of therapeutic response, and monitoring of disease progression at all stages of disease. Once defined, validation of an MF/SS biomarker FC panel will enable uptake into clinical settings along with associated standardization of protocols and reagents. This review discusses the evolution of the role of FC in evaluating blood involvement in MF and SS, considers recently published international guidelines and identifies evidence gaps for future research that will allow for standardization of FC in MF and SS.
Miscellanea Medica
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Spontaneous Haematomyelia
Authors: J. M. Holmes
Journal: BMJ (1938)

BRrTiSH X NIEDICAL JOURNAL hand, was much more common (77 per cent. of cases) b_fore the age of 30.6.There was a most striking difference between the mortality rates for the town (5.71 per cent.) and the county (15.4 per cent.).This was supported by the finding that only 3.84 per cent. of county patients, as opposed to 42.9 per cent. of town patients, received ante-natal supervision.7. The total Anaternal mortality rate for this series was 9.84 per cent.This figure was doubled in illegitimate pregnancies.8. The foetal mortality rate, including neo-natal loss, was 39.34 per cent.I wish to record my -thanks to the staff of Aberdeen Maternity Hospital for putting case-records at my disposal aiad to Professor Baird for his helpful suggestions.
Pyloric Stenosis
Authors: J. A. Balint, M. P. Spence
Journal: BMJ (1959)

Pyloric stenosis is a condition in which there is obstruction to the emptying of the stomach due to an organic lesion in the region of the pylorus.The clinical features of a consecutive series of cases in the adult have never been recorded.This lack of study of such an important condition may be due, in part, to the adequacy of standard descriptions based on clinical impression.Their inadequacy in one respect, the incidence of diarrhoea, prompted the present investigation.Methods Major and minor diagnostic criteria were formulated before the review was undertaken.Cases were not included in the series unless two major or one major and' two minor criteria were satisfied.The major criteria were: (1) a classical history-that is, the persistent vomiting of large amounts at times when the stomach should be empty, or nearly so, usually containing recognizable residues of food eaten some hours previously or accompanied by offensive eructaton;(2) the presence of visible gastric peristalsis; (3) the mean daily volume of the gastric residue* exceeding 1,000 ml. on the first or last three days on which aspiration was performed; (4) the stomach emptying by less than one-third in two hours, less than a half in three hours, or less than two-thirds in four hours, as estimated by the radiologist who performed the barium- meal examination; and (5) the finding at operation or necropsy of considerable narrowing of the lumen in the region of the pylorus.The minor criteria were: (1) a suggestive historythat is, persistent vomiting which almost satisfied the first major criterion; (2) the presence of a gastric succussion splash; (3) mean daily gastric residues exceeding 750 ml. on the first or last three days; and
Naval Warfare under Climatic Extremes--I
Authors: M. Critchley
Journal: BMJ (1945)

IIn these lectures an attempt will be made to show how medical research, especially during this war, has assisted the Royal Navy in its function of engaging the enemy in every type of climate.My task is rendered difficult by the fact that for considerations of security one is debarred from referring to the very numerous and important researches which have been prosecuted since the war began.These lectures, therefore, stripped of the names and labours of the many research workers in Australia and the United States, as well as at home-especially in the Medical Research Council-will appear, for that reason, bald, discur- sive, and unscientific.The full story Gannot yet be told.Prevention of tropical and cold-weather disorders will not be discussed, for it is intended to concentrate on three climatic aspects of naval medicine-namely, (1) naval construction;(2) clothing; and (3) efficiency.Under the first heading will be discussed how naval architects enable a ship's company to tolerate both high and low temperatures.This section will also deal with such problems as the cooling of ships, ventilation, and, in short, general habitability.The second heading will concern the modern science of clothing as an ideal means of protection against environment-" ideal " when one is mindful of the Service restrictions imposed by considerations of appearance, ruggedness, and economy in bulk.Lastly, one will discuss the impairment of efficiency under unpropitious environmental conditions; the subtle ill effects which are attributed to long service in polar or tropical waters ; the selection of those best fitted to stand up to Arctic or tropical service, and the early identification of those inherently unsuited for duty under such stresses.On looking back over naval medical history, it is clear that the sea-surgeons of Great Britain during the eighteenth century were in many respects well ahead of their colleagues ashore and that their observations were pioneer efforts in preventive medi- cine.But in the nineteenth century the French marine was * Being the Croonian Lectures delivered to the Royal College of Physicians, July 10 and 12, 1945.Desagulier system should be incorporated within one of the ships, but the idea was turned down by the Naval Surveyor.About that time a Mr. Sutton became interested in marine ventilation, but could not secure the sympathy of the authorities."I particularly remember," he wrote, " that being at a coffee-