tbuckley/cabot-search huggingface dataset:
Voltage- and use-dependent effects of lidocaine on sodium current in rat single ventricular cells.
Authors: JSanchez-Chapula, YTsuda, I RJosephson
Journal: Circulation Research (1983)

We compared the blocking effects of the local anesthetics, lidocaine and benzocaine, on the sodium current, using single rat ventricular cells to obtain further information about the voltage dependence and kinetics of local anesthetic interaction with cardiac sodium channels. We used a hybrid voltage clamp system which employed a suction pipette for passing current and internal perfusion, and a microelectrode for membrane potential measurement. Lidocaine (20 microM) and benzocaine (100 microM) produced qualitatively similar effects on sodium current when test pulses were applied infrequently. Both of these agents decreased the peak sodium current without producing a shift of the current-voltage curve. They did, however, shift the inactivation curves of sodium current to hyperpolarized potentials; the V0.5 was shifted by -9.5 mV for lidocaine and by -5 mV for benzocaine. Lidocaine produced a significant use-dependent effect that was proportional to the duration of the voltage step. Benzocaine produced only...
Patient Willingness to Enroll in Cancer Clinical Trials When Sites Return to Prepandemic Status
Authors: Arnaud Bayle, Fabrice Barlesi, Christophe Massard
Journal: JAMA Oncology (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Potassium influx in the frog atrium during the cardiac cycle.
Authors: D FJuncker, P YLee, E AGreene, RStish, VLorber
Journal: Circulation Research (1975)

A method for measuring inwardly directed transmembrane tracer flow during the cardiac cycle was developed and applied to a study of 42K influx in frog atrial trabeculae. A fine frog atrial fiber was suspended in a stream of nonisotopic perfusate into which a smaller tracer-containing bolus could be injected, subjecting the fiber to a brief, controlled exposure to the tracer at any desired point in the cardiac cycle. In an experiment, the tissue was exposed to a fixed number of radioactive pulses at a selected point in the cardiac cycle; a brief flush with nonradioactive perfusate removed ambient and extracellular label and an extended wash and removed the remaining intracellular tracer for radioassay. The same procedure was repeated at different points in the cycle, and the resulting tracer uptake at each point measured the relative influx of the particular ion. In this way, a characteristic and reproducible 42K influx profile was demonstrated which exhibited a marked drop below diastolic values during th...
A simple ultrasound approach for detection of recurrent proximal-vein thrombosis.
Authors: PPrandoni, ACogo, EBernardi, SVillalta, PPolistena, PSimioni, FNoventa, LBenedetti, AGirolami
Journal: Circulation (1993)

BACKGROUNDThe objective of this study was to develop a simple ultrasound method for measuring thrombus regression in patients with proximal deep-vein thrombosis (DVT) and to test its utility for the detection of DVT recurrence.METHODS AND RESULTSThe study comprised a cross-sectional survey and a prospective investigation (149 and 145 patients, respectively). In both phases, the normalization rate of a previously abnormal ultrasound test, applying the criterion of full compressibility of the common femoral and popliteal veins (C-US method), was assessed. In the prospective study, the vein diameter under maximum compression (thrombus thickness) was measured in the abnormal venous segments at scheduled times (1, 3, 6, and 12 months). In patients presenting with suspected DVT recurrence, the procedure was repeated and results were compared with those available from the previous examination. Noncompressibility of a previously normal(ized) venous segment and enlargement of thrombus thickness (> or = 2 mm) were ...
Coexistence of beta 1- and beta 2-adrenoceptors in human right atrium. Direct identification by (+/-)-[125I]iodocyanopindolol binding.
Authors: O EBrodde, KKarad, H RZerkowski, NRohm, J CReidemeister
Journal: Circulation Research (1983)

The highly specific beta-adrenoceptor radioligand, (+/-)-[125I]iodocyanopindolol, has been used to subclassify beta-adrenoceptors in membranes from human right atrial appendage obtained during open heart surgery. Binding of (+/-)-[125I]iodocyanopindolol was saturable (Bmax = 86.4 +/- 7.4 fmol (+/-)-[125I]iodocyanopindolol bound/mg protein, n = 4), of high affinity (KD = 53 +/- 6 pM, n = 4), rapid, reversible, and stereospecific. The relative potencies of isoprenaline, adrenaline, and noradrenaline for inhibition of (+/-)-[125I]iodocyanopindolol binding and activation of adenylate cyclase were 1:10:10, indicating a population composed mainly of beta 1-adrenoceptors. Inhibition of (+/-)-[125I]iodocyanopindolol binding by beta 1- (practolol, metoprolol, betaxolol) and beta 2- (IPS 339, ICI 118,551, zinterol, procaterol) selective drugs, however, resulted in biphasic displacement curves with slope factors (nH, pseudo Hill coefficients) significantly less than 1.0. Nonlinear regression analysis of these curves...
Alterations in transmural blood flow and body surface ST segment abnormalities produced by ischemia in the circumflex and left anterior descending coronary arterial beds of the dog.
Authors: D MMirvis, K BRamanathan
Journal: Circulation (1987)

Previous studies have documented a quantitative relation between alterations in transmural myocardial blood flow and body surface electrocardiographic distributions during rapid atrial pacing after chronic occlusion of the left circumflex coronary artery (LCx). Because other studies have described functional differences between the left anterior descending (LAD) and the LCx perfusion beds, we tested the hypothesis that these two territories exhibit quantitative differences in their responses to demand-dependent myocardial ischemia. To do so, 25 sedated dogs were studied 3 weeks after implantation of an ameroid constrictor around the proximal LCx (15 dogs, group I) or the LAD (group II). Oxygen demand was increased by rapid atrial pacing at rates of 90 to 210 beats/min, myocardial blood flow was measured by serial injections of radiolabeled microspheres, and the electrocardiographic consequences were evaluated by isopotential body surface mapping. Endocardial flows and the endocardial/epicardial flow ratio...
Scintigraphic and electrophysiological evidence of canine myocardial sympathetic denervation and reinnervation produced by myocardial infarction or phenol application.
Authors: J DMinardo, M MTuli, B HMock, R EWeiner, H PPride, H NWellman, D PZipes
Journal: Circulation (1988)

Epicardial phenol application or transmural myocardial infarction in dogs produces sympathetic denervation of myocardium apical to the site of the intervention. Because efferent denervation is probably postganglionic, reinnervation most likely occurs but has not been shown. We investigated whether 123I-labeled metaiodobenzylguanidine (MIBG), a norepinephrine analogue taken up by sympathetic nerve terminals, could provide a scintigraphic image that would detect apical sympathetic denervation and possible reinnervation. Dogs underwent MIBG scintigraphic imaging at various times after phenol application or transmural myocardial infarction. The results of MIBG scintigraphy were correlated with electrophysiological responses obtained during ansae subclaviae and norepinephrine stimulation to establish the presence of neural denervation and reinnervation. Apical defects in the MIBG scan, which were associated with either normal perfusion by thallium or a smaller-sized defect, were found consistently in dogs that...
Abstract 20245: Fluoropyrimidine-Induced Cardiac Toxicity: Challenging the Current Paradigm
Authors: Suparna Clasen, Bonnie Ky, Rupal O'Quinn, Bruce Giantonio, Ursina Teitelbaum, Joseph R Carver
Journal: Circulation (2017)

Introduction: Fluoropyrimidine chemotherapy (5-FU and capecitabine) are used to treat of various solid malignancies. Their use has been limited by cardiac toxicity, presenting as a spectrum of asym...
再発,プラチナ感受性高悪性度卵巣癌(ARIEL2第1報)ルカパリブ:国際的多施設,非盲検,第2相試験【Powered by NICT】
Authors: Swisher Elizabeth M, Lin Kevin K, Oza Amit M, Scott Clare L, Giordano Heidi, Sun James, Konecny Gottfried E, Coleman Robert L, Tinker Anna, O’Malley David M, Kristeleit Rebecca S, Ma Ling, Bell-McGuinn Katherine M, Brenton James D, Cragun Janiel M, Oaknin Ana, Ray-Coquard Isabelle, Harrell Maria I, Mann Elaina, Kaufmann Scott H, Floquet Anne, Leary Alexandra, Harding Thomas C, Goble Sandra, Maloney Lara, Isaacson Jeff, Allen Andrew R, Rolfe Lindsey, Yelensky Roman, Raponi Mitch, McNeish Iain A
Journal: The Lancet Oncology (2017)
Body building by drugs.
Journal: BMJ (1967)

Articlessources include saline," soap and antiseptic solutions,1' eyedrops," creams,'4 jellies,'5 and equipment which contains standing water or retains moisture (especially respirators and resuscitation equipment for premature infants),"-" moist brushes (for example, shaving-brushes used for depilation of the scalp before craniotomy),'8 and surgical instruments and catheters " sterilized " with an inadequate disinfectant. 20Dry sources (dust, air) are uncommon but may on occasion be important.21The hands of nurses in wards where the infection occurs are often found to carry Ps. aeruginosa and are likely to contaminate uninfected patients if the nurses do not wear rubber or plastic gloves when attending to them.22The importance of some sites which are commonly contami- nated-for example, sinks and drains-has not been clearly established.
Use of thallium-201 redistribution scintigraphy in the preoperative differentiation of reversible and nonreversible myocardial asynergy.
Authors: ARozanski, D SBerman, RGray, RLevy, MRaymond, JMaddahi, NPantaleo, A DWaxman, H JSwan, JMatloff
Journal: Circulation (1981)

Thallium-201 (201Tl) redistribution scintigraphy might differentiate reversibly from nonreversibly asynergic myocardial segments and thus predict the response of these segments to coronary artery bypass grafting (CABG). To test this hypothesis, 25 consecutive patients undergoing CABG, preoperative stress-redistribution 201Tl scintigraphy, and both pre- and postoperative resting equilibrium radionuclide ventriculography were evaluated. For both types of scintigraphic study, each patient was imaged in the same three views. Because of the effects of CABG on septal motion, this region was considered separately. Postoperative improvement was noted in 54% of 72 preoperative asynergic segments. Improvement was common not only in hypokinetic but also in akinetic and dyskinetic segments, and occurred in a similar proportion of studies performed early (less than 2 weeks) or late (3-6 months) after CABG. Thallium-201 redistribution scintigraphy was highly predictive of the pattern of postoperative asynergy: The redi...
Findings Linking Mismatch Repair Mutation With Age at Endometrial and Ovarian Cancer Onset in Lynch Syndrome—Reply
Authors: Emma J. Crosbie, Neil A. J. Ryan, D. Gareth Evans
Journal: JAMA Oncology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
A Glimpse into Diagnostic to Therapeutic EUS, With or Without Complications
Authors: IF Cherciu Harbiyeli, ET Ivan, ED Burtea, M Calita, Cazacu IM, C Popescu, V Surlin, A Saftoiu
Journal: Endoscopy (2021)

Aims Endoscopic ultrasound (EUS) gained a wide acceptance as the diagnostic and minimally invasive therapeutic approach of intra-luminal, extraluminal gastrointestinal and various non- gastrointestinal lesions. Since its introduction, EUS has undergone substantial and constant technological advances. Hence, the aim of this study was to extensively assess in dynamic the EUS experience of our tertiary referral centre.
Dissociation between renin and arterial pressure responses to beta-adrenergic blockade in human essential hypertension.
Authors: E LBravo, R CTarazi, H PDustan, J WLewis
Journal: Circulation Research (1975)

Studies were carried out in 69 patients with essential hypertension to examine the relationship between changes in plasma renin activity (PRA) and arterial pressure (BP) in response to a beta-adrenergic blocking agent, propranolol. PRA had no consistent relationship with BP during treatment, either in patients receiving propranolol alone (r = 0.12) or in those receiving a combination of diuretics and propranolol (r = 0.18). Furthermore, long-term beta-adrenergic blockade failed to inhibit increases of PRA induced by diuretics or rapid sodium depletion. These results indicate that (1) beta-adrenergic blockade can reduce BP by mechanisms other than PRA suppression; and (2) the beta-adrenergic nervous system is important, but not essential, for renin release.
Increased exercise tolerance after nitroglycerin oral spray: a new and effective therapeutic modality in angina pectoris.
Authors: AKimchi, GLee, EAmsterdam, KFujii, PKrieg, D TMason
Journal: Circulation (1983)

The prophylactic antianginal efficacy of nitroglycerin (NTG) oral spray was assessed in 20 patients with angiographically documented coronary disease and stable angina pectoris. The evaluation was by a randomized crossover trial involving treadmill exercise testing. On study day 1, a control treadmill exercise test was performed, followed 30 minutes later by a second exercise test 2 minutes after administration of either placebo (group A, 10 patients) or NTG spray 0.8 mg (group B, 10 patients). One week later, on study day 2, the patients again underwent control treadmill exercise testing followed by a second exercise test after either NTG spray (group A) or placebo (group B). NTG spray delayed the onset of anginal pain during exercise by a mean of 100 +/- 64 seconds (p less than 0.001) in 13 patients and prevented pain entirely in seven. Placebo did not significantly delay the appearance of angina and prevented chest pain in only one patient. NTG spray increased treadmill exercise duration by 31% before ...
Nonexocytotic release of endogenous noradrenaline in the ischemic and anoxic rat heart: mechanism and metabolic requirements.
Authors: ASchömig, SFischer, TKurz, GRichardt, ESchömig
Journal: Circulation Research (1987)

The release of endogenous noradrenaline and its deaminated metabolite dihydroxyphenylglycol in the myocardium have been studied in the isolated perfused heart of the rat subjected to three models of energy depletion: ischemia, anoxia, and cyanide intoxication. Anoxia and cyanide intoxication were combined with substrate deficiency at constant perfusion flow. All three energy-depleting procedures caused a similar overflow of noradrenaline which, following a constant delay of 10 minutes without increased release, amounted to more than 25% of total heart content within 40 minutes. This noradrenaline overflow was not diminished in the absence of extracellular calcium and was inhibited by the uptake1 blocker desipramine in all three experimental models, indicating a common and nonexocytotic release mechanism. In the presence of glucose, neither anoxia nor cyanide intoxication resulted in a measurable noradrenaline overflow. Conversely, blockade of glycolysis or glucose depletion prior to ischemia or cyanide po...
117P Family history of cancer and improved outcomes with first-line immunotherapy in NSCLC patients
Authors: A. Cortellini, S. Buti, M. Di Maio, R. Giusti, O. Nigro, L. Cantini, E. Bria, F. Grossi, M. Torniai, M. De Tursi, F. Citarella, F. Mazzoni, A.J. Gelibter, M. Macerelli, M.R. Migliorino, A. Russo, A. Addeo, G. Porzio, C. Ficorella, D.J. Pinato
Journal: Journal of Thoracic Oncology (2021)
Response to Comment on Garofolo et al. Insulin Resistance and Risk of Major Vascular Events and All-Cause Mortality in Type 1 Diabetes: A 10-Year Follow-up Study. Diabetes Care 2020;43:e139–e141
Authors: Monia Garofolo, Elisa Gualdani, Cristina Bianchi, Michele Aragona, Fabrizio Campi, Daniela Lucchesi, Giuseppe Daniele, Roberto Miccoli, Paolo Francesconi, Stefano Del Prato, Giuseppe Penno
Journal: Diabetes Care (2021)

Gonzalez-Clemente et al. (1) claim that a simpler though efficient assessment of cardiovascular risk in people with type 1 diabetes (T1D) is much needed. Since we showed that the estimated glucose disposal rate (eGDR) was an independent predictor of cardiovascular (CVD) and coronary artery disease (CAD) in people with T1D, they evaluated whether cutoff eGDR values could be calculated to be used in clinical practice to stratify CVD risk. They used the Steno Type 1 Risk Engine (ST1RE) (2) in 179 T1D subjects without CVD to identify 10-year risk level for a first CVD event: low (<10%), moderate (10–20%), and high (≥20%) risk. An eGDR <8.52 mg/kg/min was associated with moderate/high …
Association of Treatment Facility Characteristics With Overall Survival After Mohs Micrographic Surgery for T1a-T2a Invasive Melanoma
Authors: Shayan Cheraghlou, Sean R. Christensen, David J. Leffell, Michael Girardi
Journal: JAMA Dermatology (2021)

<h3>Importance</h3> Early-stage melanoma, among the most common cancers in the US, is typically treated with wide local excision. However, recent advances in immunohistochemistry have led to an increasing number of these cases being excised via Mohs micrographic surgery (MMS). Although studies of resections for other cancers have reported that facility-level factors are associated with patient outcomes, it is not yet established how these factors may affect outcomes for patients treated with Mohs micrographic surgery. <h3>Objective</h3> To evaluate the association of treatment center academic affiliation and case volume with long-term patient survival after MMS for T1a-T2a invasive melanoma. <h3>Design, Setting, and Participants</h3> In a retrospective cohort study, 4062 adults with nonmetastatic, T1a-T2a melanoma diagnosed from 2004 to 2014 and treated with MMS in the National Cancer Database (NCDB) were identified. The NCDB includes all reportable cases from Commission on Cancer–accredited facilities and is estimated to capture approximately 50% of all incident melanomas in the US. Multivariable survival analyses were conducted using Cox proportional hazards models. Data analysis was conducted from February 27 to August 18, 2020. <h3>Exposures</h3> Treatment facility characteristics. <h3>Main Outcomes and Measures</h3> Overall survival. <h3>Results</h3> The study population included 4062 patients (2213 [54.5%] men; median [SD] age, 60 [16.3] years) treated at 462 centers. Sixty-two centers were top decile–volume facilities (TDVFs), which treated 1757 patients (61.9%). Most TDVFs were academic institutions (37 of 62 [59.7%]). On multivariable analysis, treatment at an academic center was associated with a nearly 30% reduction in hazard of death (hazard ratio, 0.730; 95% CI, 0.596-0.895). In a separate analysis, treatment at TDVFs was also associated with improved survival (hazard ratio, 0.795; 95% CI, 0.648-0.977). <h3>Conclusions and Relevance</h3> In this cohort study, treatment of patients with T1a-T2a invasive melanoma excised with MMS at academic and top decile–volume (≥8 cases per year) facilities was associated with improved long-term survival compared with those excised by MMS at nonacademic and low-volume facilities. Identification and protocolization of the practices of these facilities may help to reduce survival differences between centers.
Outcome measures in asthma
Authors: N. Barnes
Journal: Thorax (2000)

on behalf of the FACET International Study GroupThe identification, prevention, and prompt treatment of exacerbations are major objectives of asthma management.We looked at change in PEF, symptoms, and use of rescue agonists during the 425 severe exacerbations that occurred during a 12-month parallel group study (FACET) in which low and high doses of budesonide with and without formoterol were compared in patients with asthma.Oral corticosteroids were prescribed for severe exacerbations, the main study end point, defined as the need for a course of oral corticosteroids (n=311) or a reduction in morning PEF of >30% on two consecutive days, PEF, symptoms, and bronchodilator use over the 14 days before and after the exacerbation were obtained from diary cards.Exacerbations were characterized by a gradual fall in PEF over several days, followed by more rapid changes over 2-3 days: an increase in symptoms and rescue agonist use occurred in parallel, and both the severity and time course of the changes were similar in all treatment groups.Exacerbations identified by the need for oral corticosteroids were associated with more symptoms and smaller changes in PEF than those identified on the basis of PEF criteria.Female sex was the main patient characteristic associated with an increased risk of having a severe exacerbation.Exacerbations may be characterized predominantly by change in symptoms or change in PEF, but the pattern was not affected by the dose of inhaled corticosteroid or by whether the patient was taking formoterol.(
Impact of the Sars-Cov-2 Pandemic on Gastroenterology Units in Italy: a National Survey
Authors: M Maida, S Sferrazza, E Savarino, L Ricciardiello, A Repici, F Morisco, M Furnari, L Fuccio, GC Morreale, A Vitello, P Burra, S Marchi, B Annibale, A Benedetti, D Alvaro, G Ianiro
Journal: Endoscopy (2021)

Aims This is a prospective observational web-based survey aimed to assess the impact of SARS-CoV-2 pandemic on Gastroenterology Units in Italy.