tbuckley/cabot-search huggingface dataset:
Intrathoracic Meningocele
Authors: J. C. A. Raison
Journal: Thorax (1956)

The diagnosis of intrathoracic meningocele, lying primarily in the paravertebral gutter and radiologically resembling a neurofibroma, has been said to be easy if the existence of the con- dition is previously considered.In view of the rarity of the condition, however, it is understand- able that in many of the cases described the diagnosis has been made unexpectedly at operation or necropsy.Apart from a mention by Groedel (1936) in a textbook of radiological diagnosis, intrathoracic meningocele has not found a place in any major works of radiology or thoracic disease.An extensive study of hourglass tumours by Heuer (1929) and that by Schmorl and Junghanns (1932) describe only solid intrathoracic tumours.A wide review of the literature upon spina bifida by Ingraham and others (1944) like- wise did not include thoracic meningocele.Twenty-six cases have received mention in the world literature, not all of them fully documented.Two further cases are now presented, one being of particular interest, having been discovered at about the time Pohl (1933) first described the con- dition.CASE REPORTS CASE 1.-H.B., a healthy male postal superintendent, aged 39, was found to have a neurofibroma-like shadow in the right hemithorax at mass miniature radiography.He was entirely asymptomatic.He had never had a chest radiograph before this.There was no relevant previous medical history.The patient was admitted to the Thoracic Surgical Unit, Warwick.on December 1, 1954.There was no evidence of von Recklinghausen's disease superficially, nor of cafe-au-lait spots on the skin.Skeletal development was normal.There was no family history of cutaneous neurofibromatosis or of congenital bony deformity.There was no history of severe trauma.Physical signs were normal in the chest and abdomen.A full neurological examination was carried out and no abnormalities shown.The patient denied any pains or any recurrent chest infections.A radio- graph of the chest (Fig. I) showed a fairly well- defined, apparently solid opacity in relation to the eighth and ninth vertebral bodies in the right hemi- thorax.A lateral film showed enlargement of the
Painful Sequelae of Peripheral Nerve Trauma
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Novel and founder variants of <scp> <i>SERPINA12</i> </scp> in Chinese patients with autosomal recessive palmoplantar keratoderma
Authors: Yihe Liu, Yingjian Tan, Juan Liu, Zhongya Song, Linghan Hu, Ran Mo, Zhiming Chen, Yong Yang
Journal: British Journal of Dermatology (2022)

1. We extend the spectrum of SERPINA12 variants in palmoplantar keratodermas. 2. The recurrent variant c.970_971del, mainly prevalent in the East Asia population, was proved to be a founder variant. 3. Considerable SERPINA12-related palmoplantar keratoderma patients could be identified from autosomal recessive, non-mutilating, diffused palmoplantar keratoderma patients. 4. Other serpin family members or their co-effect may participate in the etiologies of underexplored hereditary palmoplantar keratodermas.
Hyperviscosity syndrome secondary to a myeloma‐associated IgG1κ paraprotein strongly reactive against the HIV‐1 p24 gag antigen
Authors: David K. Jin, Maja Nowakowski, Martin Kramer, David W. Essex
Journal: American Journal of Hematology (2000)

Hyperviscosity syndrome secondary to hypergammaglobulinemia is a rare and potentially fatal complication in patients with human immunodeficiency virus type-1 (HIV-1) infection. We studied an HIV-1-positive patient with symptomatic hyperviscosity attributable to IgG1κ multiple myeloma. The patient initially responded to plasmapheresis and was subsequently treated with cytotoxic immunosuppressive chemotherapy. The patient remained asymptomatic during a 3-year follow-up period. The monoclonal IgG1κ gammopathy evolved to a biclonal variant of the same subtype with an expansion of marrow plasma cell population. Western blot analysis demonstrated that this myeloma-associated paraprotein was strongly reactive against the HIV-1 p24 gag antigen. Am. J. Hematol. 64:210–213, 2000. © 2000 Wiley-Liss, Inc.
Elephant genotypes reveal the size and connectivity of transnational ivory traffickers
Authors: Samuel K. Wasser, Charles J. Wolock, Mary K. Kuhner, John E. Brown, Chris Morris, Ryan J. Horwitz, Anna Wong, Charlene J. Fernandez, Moses Y. Otiende, Yves Hoareau, Zofia A. Kaliszewska, Eunjin Jeon, Kin-Lan Han, Bruce S. Weir
Journal: Nature Human Behaviour (2022)
Best Practices for the Conduct of Antiracist Research
Authors: Diana Montoya-Williams, Kate E. Wallis, Andrea F. Duncan
Journal: JAMA Pediatrics (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Investigations of Equivocal suicides
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Novel use of ctDNA to identify locally advanced and metastatic upper tract urothelial carcinoma.
Authors: Heather L. Huelster, Elizabeth A. Green, Alex C. Soupir, Esther N. Katende, Kyle M. Rose, Shreyas U. Naidu, Scott Michael Gilbert, Brandon J. Manley, Michael Adam Poch, Wade J. Sexton, Philippe E. Spiess, Alice Yu, Youngchul Kim, Pan Du, Shidong Jia, Il-Jin Kim, Lu Tan, Liang Wang, Roger Li
Journal: Journal of Clinical Oncology (2022)

543 Background: Upper tract urothelial carcinoma (UTUC) is an aggressive cancer for which use of neoadjuvant chemotherapy (NAC) is limited by suboptimal clinical staging prior to nephroureterectomy. Detection of circulating tumor DNA (ctDNA) is associated with locally advanced and metastatic urothelial carcinoma of the bladder and may help identify UTUC patients who would benefit from NAC. Here we examine the feasibility and utility of plasma ctDNA in the diagnosis of non-organ confined high-risk UTUC. Methods: Patients with high-grade cTa-T2 UTUC without radiographic evidence of metastatic disease undergoing up-front radical nephroureterectomy (RNU) were prospectively accrued. Blood was collected preoperatively on the day of surgery, and plasma and buffy coat were processed for extraction of ctDNA. FFPE samples from RNU were used for tissue genomic DNA extraction. Next-generation sequencing (NGS) was used for variant profiling. Plasma and somatic tissue mutations were called by comparing with matched buffy coat samples. Detection of cancer variants with a mutation allele frequency (MAF) ≥ 0.25% and hotspot variants with a MAF down to 0.1% were reported for plasma samples targeted by a NGS panel (PredicineCARE). Variants with a MAF ≥ 5% and hotspot variants with a MAF down to 2% were reported for FFPE samples. Results: NGS analyses of matched FFPE and plasma samples were successfully performed for all 15 accrued UTUC patients. Alterations in MYC amplification (62%), TERT promoter (62%), TP53 (38%), FGFR3 (31%), ERBB2 (25%), ARID1A (19%), and PIK3CA (19%) were demonstrated in urothelial tumor tissue. Matched plasma ctDNA showed prevalent alterations in the TERT promoter (47%), TP53 (30%), ARID1A (20%), ERBB2 (20%), FGFR3 (20%), and PIK3CA (17%). Five patients (33%) had detectable plasma ctDNA mutations concordant with tumor-based genotypes using the targeted NGS panel. All patients with detectable preoperative ctDNA had advanced staging (≥pT2 or ≥pN1) and lymphovascular invasion on final pathology, resulting in a 71.4% sensitivity. The panel was 100% specific with no patients with pTis, pTa, or pT1 and pN0 having detectable concordant ctDNA mutations. Conclusions: Prospective ctDNA analysis using a targeted NGS panel is a feasible nonsurgical approach to prediction of high-risk UTUC and has the potential for identification of upper tract urothelial cancer patients that may benefit from NAC.
Cervical Spondylosis With Radiculopathy
Authors: Bernard Jacobs
Journal: JAMA (1970)

We have analyzed the results of 90 anterior cervical diskectomies combined with fusion of the spine in 62 patients with cervical spondylosis. Good to excellent results were obtained in 82% (51) of patients who returned for follow-up examinations. The results were superior in the presence of single-level disk disease, and were better following multilevel rather than limited surgical eradication in the presence of multilevel disk disease. Myelography was found to be a useful adjunct to preoperative clinical assessment of the symptomatic disk levels. The low incidence of complications encountered in this series further confirms the ease and efficacy of the anterior approach in the surgical treatment of cervical spondylotic radiculopathy.
MALARIAL HEMOGLOBINURIA.
Authors: WILLIAM BRITT. BURNS
Journal: JAMA (1900)

We are accustomed to using this term—the principal symptom of the disease—because it overshadows all others. Under ordinary circumstances it makes the diagnosis, and the layman knows its import. The synonyms are, black-water fever (Das Schwarzwasser Fieber), hematuria, hemoglobinuric fever, swamp fever, icterohematuric fever; fièvre bilieuse hématurique, first described by French naval surgeons stationed at Nossibe, a French settlement off the northwest coast of Madagascar. The pathology and pathologic anatomy of malarial hemoglobinuria is in all essential particulars the same as—and in fact is—that of a malignant malaria, with the addition of hemoglobin in the urine and rapidly increasing jaundice. There is always a history of one or more paroxysms—chills and fever—with insufficient or no treatment. A cachectic may have had no active manifestations of malaria for months, and after undue exposure or fatigue, have a violent hemoglobinuria and die in twenty-four hours. Usually, however, there are two, three or four,
Prognostic factors associated with malignant somatic transformation (MST) of germ cell tumors (GCT) in a Mexican cohort: The experience of the Instituto Nacional de Cancerología, Mexico (NCIM).
Authors: Nora Sobrevilla-Moreno, Delia Pérez-Montiel, Diego López-Macias, Diana Gonzalez-Rodriguez, Pedro Sobrevilla-Calvo, Miguel Angel Alvarez Avitia
Journal: Journal of Clinical Oncology (2022)

427 Background: MST is a rare entity defined as the development of somatic non-germ cell malignancies within GCT, its incidence varies between 2.7% and 8.6% of GCT’s. Previously reported favorable prognostic factors include synchronous diagnosis of MST and GCT, absence of non-pulmonary visceral metastases (NPVM) and presence of rhabdomyosarcoma. Methods: Retrospective study to describe prognostic factors of MST in GCT in a Hispanic population. Patients (pts) with diagnosis of MST from 2006 to 2019 were identified from the GCT database of the NCIM. Pts’ characteristics and outcomes were collected from clinical charts and recorded. Overall survival (OS) was performed with the Kaplan Meier (KM) method in the whole cohort and in patients with advanced disease (AD) (stage II and III). Comparisons were calculated with the log-rank test for KM and Chi squared test for categorical factors. Results: Seventy-one pts with MST were included in the overall population (OP). Non-seminoma 95.8%; testicular primary 97.2%; clinical stage (CS) I 32.4%, II 16.3%, III 49.3%; S2-S3 42.3%, 39.6% poor IGCCCG prognosis, 11.3% NPVM. Type of MST: 56.3% rhabdomyosarcoma (RMS), 21.1% spindle cell sarcoma, 12.7% PNET, 9.9% adenocarcinoma. 18.3% more than 1 MST histology. Median follow-up: 43.8 months (m). For the OP, mOS 71.1m (95% CI 80.0 – 119.2). OS for CS I have not been reached (NR). Forty-seven pts with AD were included, mOS 37m (95% CI 9.69 – 64.36). Characteristics associated with prognosis for OS for the OP and the AD cohorts are summarized in table. Pts with AD and RMS had more frequently a synchronous tumor (87.5% vs 58.3%, p=0.02) and absence of surgery for MST (70.8% vs 37.5%, p=.02). Conclusions: As far as we know, this is the largest cohort of hispanic pts with MST. Prognostic factors differed between OP and AD cohorts. Pts with MST and AD have a poor prognosis. Synchronous diagnosis of MST and presence of rhabdomyosarcoma are adverse prognostic factors for AD pts. Further study with a larger population is needed to verify these findings. Univariate analysis for OS.[Table: see text]
Tcf1 preprograms the mobilization of glycolysis in central memory CD8+ T cells during recall responses
Authors: Qiang Shan, Shengen Shawn Hu, Shaoqi Zhu, Xia Chen, Vladimir P. Badovinac, Weiqun Peng, Chongzhi Zang, Hai-Hui Xue
Journal: Nature Immunology (2022)
THE AMERICAN MEDICAL ASSOCIATION.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Narcolepsy
Authors: H. A. Palmer
Journal: BMJ (1941)

obvious reason'why different kinds of bacteria should be carried into them at the time of their infliction.Failure to isolate a given kind of bacterium from a wound is not conclusive proof that no bacteria of that kind were present; oii thp other hand, the methods of culture employed in this investigation are reasonably sensitive, and the most probable explanation of the failure to isolate pyogenic cocci from more than three wounds seems to be that theyi were not present in those from which they were no.obtained.Summary Str.pyogenies and coagulase-positive staphylococci were each obtained from two wounds out of 31 early air-raid wounds examined within forty-eight hours of their infliction.Cl. welchii was obtained from 8, of which 6 showed no clinical evidence of its presence.Six of the wounds yielded no bacteria of any kind.Thanks are due to the six surgeons who kindly allowed the collection of material in their operating theatres, and tp Prof.
Book Review Spontaneous and Experimental Leukaemia in Animals . By Julius Engelbreth-Holm, M.D., director of the Cancer Research Laboratory, Danish Anti-Cancer League, and chief pathologist of the Finsen Institute and Radium Station, Copenhagen. 8°, cloth, 245 pp., with 44 illustrations and 3 tables. Edinburgh: Oliver and Boyd, 1942. 15 shillings.
Journal: New England Journal of Medicine (1943)
Antipneumococcic Serum
Authors: J. W. Washbourn
Journal: BMJ (1897)

ANTIPNEUMOCOCCIC SERUM.F 2 swelling appeared at the spot of inoculation, and lasted nine days.February 7th; 150 c.cm. living broth cultivation.A diffase swelling appeared, but soon subsided.The temperature reachecd 104.20 F. February 21st; 100 c.cm. living broth cultivation injected into both sides of the neck.A swelling appeared on both sides, more marked on right side.This subsided in a few days.The temperature reached Io3°F.March 3rd; I 12 c.cm. living brothicultivation injected into both sides of neck.The animal appeared ill for twenty-four hours, and there was some swelling at the spot of injection.March 14th; 850 c.cm. broth cultivation injected into both sides of the neck.Some swelling occurred on both sides, but soon disappeared.Animal ill for twenty-four hours.March 27th; 200 c.cm. broth cultivation injected into both sides of the neck.Marked swelling occurred on both sides, and lasted two days.On April 3rd the near fore leg became hot, swollen, and tender, and in a few days an abscess formed and burst.The pus contained streptococci.Probably the infection was
Dueling KRASG12C Inhibitors Achieve Responses
Journal: Cancer Discovery (2019)

Abstract Clinical trials of two KRASG12C inhibitors, MRTX849 and AMG 510, have shown robust efficacy in phase I trials including patients with non-small cell lung cancer. Data on the effectiveness of the drugs in other tumor types, such as colorectal cancer, have been more limited. Regardless, researchers are excited about the possibility of targeting proteins long thought “undruggable.”
MANAGEMENT OF DIABETES MELLITUS
Authors: H. P. Himsworth
Journal: BMJ (1936)

PART I Diabetes mellitus is a disease that can now be treated as efficiently in general -practice as in the clinic or hospital.The whole treatment can be summed upg in two simple rules: (1) Eliminate and keep entirely absent -from the urine every trace of acetone (ketone) bodies.(2) Remove or reduce to the smallest proportion loss of sugar in the urine.These rules are carried out by giving sufficient carbohydrate to prevent the production of acetone bodies and, if necessary, insulin to enable the patient to utilize this carbohydrate.Before proceeding further the tests for acetonuria and glycosuria, by which treatment is, con- trolled, will be outlined. TESTS FOR ACETONE BODIESFerric Chloride Test.-Fill a test tube two-thirds full of urine and add drop by drop a 10 per cent.aqueous solution of ferric chloride.If the test is positive a deep Burgundy-red colour develops.Similar colours are given by various drugs -for example, salicylates-so a positive reaction must always be checked by the nitroprusside test, which gives no reaction with such drugs.The ferric chloride test only detects acetone bodies when they are present in large amounts.Cases in which this test is positive must be regarded as medical emergencies; they are within the danger zone of coma, aid therefore will not be discussed in this article.Nitroprusside Test.-(For this test it is convenient to powder together 100 parts of ammonium sulphate and 1 part of sodium nitroprusside crystals.This mixture keeps well in a tightly stoppered bottle.)Put one inch of the crystalline mixture in the test tube, add one inch of urine, shake well, add one inch of strong (0.88) ammonia, shake, and allow to stand for five minutes.*If the test is positive a permanganate * Many normal urines give with this test a transient pink colour which is not due to acetone, but the colour always fades within five minutes.Diet 1.