POS1077 CLINICAL AND RADIOLOGICAL FEATURES OF SEROPOSITIVE PSORIATIC ARTHRITIS
Authors: H. EL Moutaouakil, K. Nassar, S. Janani
Journal: Annals of the Rheumatic Diseases (2021)

Background: Rheumatoid factor (RF) and anti-cyclic citrullinated peptides (anti-CCP) are two highly specific laboratory markers for rheumatoid arthritis. However, they can also be found in other chronic inflammatory arthritis such as psoriatic arthritis (Psa). Objectives: The aim of our study is to analyze the different epidemiological and paraclinical characteristics of seropositive psoriatic arthritis. Methods: Descriptive and analytical retrospective study from January 2010 to December 2020 conducted in the Department of Rheumatology of the University Hospital of Ibn Rochd, Casablanca. Inclusion criteria: patients diagnosed with psoriatic arthritis according to the CASPAR or ASAS 2009 criteria, regardless of the immunological status (RF/anti-CCP). The patients were then divided into two groups: seropositive (positive anti-CCP and / or positive RF) and seronegative. A univariate analytical study was performed by jamovi version 1.2.27 Results: 80 patients were enrolled. 22 patients were seropositive (Group 1) and 58 were seronegative (Group 2). In the group 1, the mean age was 51.1 years (+/- 9.45). The sex ratio M/F was 0.29, the mean age of onset was 43.5 years (+/- 10.4), the mean duration of disease was 9.55 +/- 8 years. All patients had skin involvement. Polyarticular involvement was present in all cases; axial involvement was present in 68.18% of cases and enthesitis in 68.18% of cases. All patients were HLA B 27 negative. The presence of X-ray and / or ultrasound bone erosions in addition to signs of destruction was in 81.8% of cases. The response to treatment with (corticosteroids / NSAIDs / DMARDs) was partial in 70.58%. In group 2, the mean age was 50.7 years (+/- 15.8). The sex ratio M/F was 1.14, the mean age of onset was 37.4 years (+/- 16.5), the mean duration of disease was 13.3 years (+/- 9.5). Skin involvement was present in 50% of patients. Polyarticular involvement was present in all cases, axial involvement was present in 67.24% of cases and enthesitis in 56.9% of cases. All patients were HLA B 27 negative. The presence of X-ray and / or ultrasound bone erosions in addition to signs of destruction was in 56.9% of cases. The response to treatment with (corticosteroids / NSAIDs / DMARDs) was partial in 57.14%. Conclusion: The presence of anti-CCP according to several studies is linked to the presence of deformities, dactylites and radiological erosions (1,2). In our series, seropositivity was accompanied by the erosive nature of the destruction, as well as a tendency to resistance to treatment. References: [1]Kim KY, Lee YH. Anti-cyclic citrullinated peptide antibody in psoriatic arthritis: a meta-analysis of its frequency and association with clinical features. Z Rheumatol. mai 2020;79(4):397-403. [2]Hagiwara S, Tsuboi H, Terasaki T, Terasaki M, Toko H, Shimizu M, et al. Association of anti-cyclic citrullinated peptide antibody with clinical features in patients with psoriatic arthritis. Modern Rheumatology. 3 mars 2020;30(2):365-72. Table 1. Comparison of characteristics of seropositive and seronegative PsA patients Items Group 1 Seropositive patients (n=22) Group 2 Seronegative patients (n=58) p-value Age (years) 51.1 +/-9.45 50.7 +/- 15.8 0.9 Sex ratio M/F 0.29 1.14 0.013 Age onset (years) 43.5 +/- 10.4 37.4+/- 16.5 0.123 Skin involvement (%) 100 50 0.009 Bone erosions (%) 81.1 56.9 &lt;0.001 Response to treatment (%) 70.58 51.14 &lt;0.001 Disclosure of Interests: None declared.