tbuckley/cabot-search huggingface dataset:
FRIDAY 11TH SEPTEMBER
Authors: Asha Senaratl, M Thomnson, St Mary', Seow-Chone Af, Eu Kw, H Yh, H Goh, Rose Sa, Smart2 Cj, Trejdosiewicz2 Lk, Howdle2 Pd, R Sturgess, Marsh Mn, Crowe Pt, P Kontakou, J Furlong, S Alani, Ren Apci, Ceronson On, B Saal, V Taylor, D 4urday, P Bishop, C Probert, P Emmett, H Cripps, K Heaton, M Aslam, J Batten, Thj Florn, R Sidebotham, J Baron
Journal: Gut (1992)

Flexible sigmoidoscopy examines 40 cm more colon than a rigid sigmoidoscope.Its universal acceptance has been hindered by the lack of facilities available in clinics to give enemas.As a result we have performed outpatient flexible sigmoidoscopy on the unprepared bowel f or many years.Although views are sometimes excellent they may be poor.This randomised controlled trial compares the effect of an enema administered at home to no preparation on the views obtained at flexible sigmoidoscopy.Patients 118 patients were entered.There were 52 men and 66 women with a mean age of 53 years. 58patients were sent an enema with instructions on its use and an explanatory letter prior to attending out patients. 60patients received an explanatory letter only. 10patients sent letters and/or enemas did not attend the clinic.Results 94% of patients sent enemas used them.The overall percentage view of mucosa seen on flexible sigmoidoscopy after an enema was 85% and without an enema was 74% (p<0.02).The mean length of colon examined both with and without an enema was 52 cm.In the enema group the full distance could not be reached due to faeces in 15% and without an enema in 35% (p<0.02).74% of patients found the enema easy to use.There were no complications and 4 patients had minima] soiling.In those who were not sent an enema 82% said they would have been willingto use one at home had it been sent.Use of an enema at home prior to attending an outpatient clinic is both acceptable to the patients and safe.The views obtained are more satisfactory than without preparation and thexefore is likely to enhance the diagnostic yield of the examination.We recommrend that this be the normal practice prior to outpatient flexible sigmoidoscopy.
Endogeneous nitric oxide in patients with idiopathic dilated cardiomyopathy inhibits positive inotropic response to adenylate cyclase stimulation Soichiro Ota, Katsuya Hata, Hiroya Kawai, Hideyuki Takaoka, Toshiro Shinke, Yoichi Kijima, Takeomi Murata, Yoshiaki Ueda, Hidenari Matsumoto, Yoshio Yamanaka, Yoko Miyata, Ryohei Yoshikawa, Mitsuhiro Yokoyama. First Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
Journal: Journal of the American College of Cardiology (2001)
IN-HOSPITAL MANAGEMENT AND OUTCOMES IN HIV SEROPOSITIVE AND SERONEGATIVE INDIVIDUALS WITH ACUTE NON-ST SEGMENT ELEVATION MYOCARDIAL INFARCTION: RESULTS FROM THE NATIONAL INPATIENT SAMPLE DATABASE
Authors: Reza Masoomi, Zubair Shah, Buddhadeb Dawn, Kamal Gupta
Journal: Journal of the American College of Cardiology (2016)
PHARYNGO-MYCOSIS.
Authors: HOMER M. THOMAS
Journal: JAMA (1894)

The term, pharyngo-mycosis, signifies a fungoid condition of the pharynx. It is a parasitic affection of the mucous membrane of the mouth, and manifests itself in white patches of varying size. These are found to contain epithelial cells and parasitic forms of a vegetable nature, the distinctive ones being called leptothrix threads. The tonsillar crypts of healthy persons are sometimes more or less plugged by these vegetable masses, but it is only when the plugs are large enough to project slightly over the surface that they come under observation. Mycosis leptothrix occurs in two forms, diffused and circumscribed. In the diffuse form the entire tongue is coated with a shiny, milkwhite mass, which is frequently of sufficient density to obscure from view the vtlliform papillæ. Movement of the tongue and sense of taste are not lost, and there is no interference with the general health. In the circumscribed form, white
Evolution of the repression mechanisms in circadian clocks
Authors: Jonathan Tyler, Yining Lu, Jay Dunlap, Daniel B. Forger
Journal: Genome biology (2022)

Abstract Background Circadian (daily) timekeeping is essential to the survival of many organisms. An integral part of all circadian timekeeping systems is negative feedback between an activator and repressor. However, the role of this feedback varies widely between lower and higher organisms. Results Here, we study repression mechanisms in the cyanobacterial and eukaryotic clocks through mathematical modeling and systems analysis. We find a common mathematical model that describes the mechanism by which organisms generate rhythms; however, transcription’s role in this has diverged. In cyanobacteria, protein sequestration and phosphorylation generate and regulate rhythms while transcription regulation keeps proteins in proper stoichiometric balance. Based on recent experimental work, we propose a repressor phospholock mechanism that models the negative feedback through transcription in clocks of higher organisms. Interestingly, this model, when coupled with activator phosphorylation, allows for oscillations over a wide range of protein stoichiometries, thereby reconciling the negative feedback mechanism in Neurospora with that in mammals and cyanobacteria. Conclusions Taken together, these results paint a picture of how circadian timekeeping may have evolved.
Abstract 17133: A Novel, Shear-Thinning and Rapidly Self-Healing Polymer Nanoparticle Hydrogel Diminishes Post-Operative Adhesions in Rodent and Ovine Models of Cardiac Adhesion Formation
Authors: Lyndsay M Stapleton, Amanda N Steele, Hanjay N Wang, Michael J Paulsen, Hector L Hernandez, Haley J Lucian, Anton A Smith, Anthony C Yu, Akshara D Thakore, Anahita Eskandari, Justin M Farry, Kiah N Williams, Camille N Hironaka, Kailey P Totherow, Kevin J Jaatinen, Eric A Appel, Y. J Woo
Journal: Circulation (2018)

Objective: Adhesions develop after 95% of operations, represent a major clinical challenge, and cost the U.S healthcare system $2.5B annually. In cardiac surgery, adhesions are problematic during re-operations, increasing operative times and posing risks of hemorrhage and injury to the heart and lungs during sternal reentry and cardiac dissection. We hypothesized that shear-thinning, self-healing polymer nanoparticle hydrogels (PNP) would provide a viscoelastic barrier, effectively preventing adhesion formation (Fig 1A). Methods: Multiple PNP formulations underwent rheologic characterization. Male Sprague Dawley rats (n=52) underwent permanent ligation of the LAD to induce robust postinfarct adhesions, followed by epicardial application of PNP (200L), Seprafilm®(1cm 2 ), or no treatment. Male Dorset sheep (n=8) underwent an anterolateral epicardial abrasion followed by application of PNP (25mL), Seprafilm® (12 cm 2 ), or no treatment. Degree of adhesion formation, standardized dissection time, heart function, and immune response were assessed 4-weeks following surgery. Results: PNP exhibited formulation-dependent mechanical properties indicating the effect of hydrogel stiffness on adhesion barrier efficacy (Fig 1B). Infarct size and heart function were controlled to ensure similar inflammatory responses contributing to adhesion formation across treatment groups. Treatment with certain PNP formulations significantly reduced the development of adhesions compared to controls (Fig 1C). Ovine hearts treated with the PNP 1:10 revealed a pristine epicardial surface (Fig 1D, 1E, and 1F) and resulted in a shorter dissection time relative to the controls (Fig 1G). Conclusion: Administration of a shear-thinning, self-healing hydrogel reduces the extent of adhesion formation in the thoracic cavity following surgery in small and large animal models. PNP provides an easily delivered, scalable solution for post-operative adhesion prevention.
EXPERT TESTIMONY AND MEDICAL EXPERTS . . .
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Photo Credits
Authors: Timothy O'leary, Sally-Beth Buckner, Curtis Ollayos
Journal: JAMA (1998)

rescreening alone.This is not necessarily true; PAPNET cannot image up to the edges of the glass slides.Side-by-side comparison of manual rescreening and PAPNET-assisted rescreening could only have made PAPNET look worse.Koss, Mango and Radensky, and Schechter believe that our conclusions cannot be generalized because we are a "highquality reference laboratory serving a low-risk population of women. . .."The percentage of abnormal Pap smears found in our laboratory is not unlike that of many health care systems.The careful definition of both our patient population and laboratory practices enables individual health care institutions to determine the applicability of our findings.Seventy-five percent of invasive cervical cancers are diagnosed in women who have not had a Pap smear in the previous 5 years. 5Access to regular Pap screening, such as found in the military health system, is clearly a cost-effective method by which to reduce cervical cancer mortality.Health care dollars are scarce.The benefits and costs of new technological approaches for reducing cervical cancer deaths must be compared with those of effective "low-tech" methods when considering their widespread use.
Successful restoration of blood flow using contiuous infiltration of naked-DNA encoding vascular endothelial growth factor Ariel Roguin, Samy Nitecki, Irit Rubinstein, Mory Resnik, Nina S. Levy, Zaid Abassi, Orit Lache, Aharon Hoffman, Andrew P. Levy. Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
Journal: Journal of the American College of Cardiology (2001)
Incremental prognostic value of gated myocardial perfusion SPECT in elderly patients Sean W. Hayes, Enrique F. Schisterman, Howard C. Lewin, Leslee J. Shaw, Raluca D. Agafitei, John D. Friedman, Guido Germano, Daniel S. Berman. Cedars-Sinai Medical Center, Los Angeles, CA
Journal: Journal of the American College of Cardiology (2001)
Rare Presentation of Inflammatory Lung Disease and Subcutaneous Nodules on FDG PET/CT Scan
Authors: Abtin Doroudinia, Mehrdad Bakhshayesh Karam, Farhad Yousefi, Niloufar Ghadimi
Journal: Clinical Nuclear Medicine (2022)

Abstract We present a 37-year-old man with cough and progressive dyspnea for the past 3 years. According to inconclusive chest CT scan and lung biopsy histopathology findings, the patient referred for 18 F-FDG PET/CT scan for further evaluation. Classic pulmonary manifestations of Langerhans cell histiocytosis were seen on CT images with intense FDG uptake on PET scan. Moreover, PET/CT revealed multiple hypermetabolic subcutaneous foci throughout his body. Finally, the patient was treated with corticosteroids. Follow-up chest CT images demonstrated improvement of lung lesions in accordance with improvement in the patient's symptoms. We are briefly discussing differential diagnoses in this patient.
Has the incidence of myocardial infarction changed over time? A population based study in Olmsted County, MN Veronique L. Roger, Steven J. Jacobsen, Guy S. Reeder, Tauqir Y. Goraya, Susan Weston, Thomas E. Kottke, Barbara P. Yawn, Robert L. Frye. Mayo Clinic, Rochester, MN
Journal: Journal of the American College of Cardiology (2001)
A Tale of 2 Blocks
Authors: Ajay Pillai, Kenneth A. Ellenbogen, Santosh K. Padala
Journal: Circulation (2021)

Figure 1.Presenting ECG demonstrates atrial fibrillation with a ventricular rate of 144 bpm and a QRS duration of 160 milliseconds with a typical left bundle-branch block morphology (QS in V 1 , broad monophasic notched R wave in leads 1, V 5 , and V 6 ).
Estrogen use is associated with reduced need for target lesion revascularization in postmenopausal diabetic women after coronary stenting Partha Manchikalapudi, Masroor Khan, Ramin Arani, Vijay Misra, Ming Liu, Gregory Chapman, Suzanne Oparil, Larry Dean. UAB Medical Center, Birmingham, AL
Journal: Journal of the American College of Cardiology (2001)
A scale to assess the global impact of hand involvement of patients with systemic sclerosis
Journal: British Journal of Dermatology (2022)

Abstract Linked Article: Sibeoni et al. Br J Dermatol 2022; 186:96–105. Systemic sclerosis (or scleroderma) is an autoimmune disease (in which the body’s immune system begins to target its own cells and tissues) potentially affecting multiple organ systems including the skin, lungs, gastrointestinal tract and cardiovascular system. Hand involvement is central in this chronic disease and has a severe impact on patients’ quality of life. As hand involvement is a major cause of pain and disability it is therefore necessary to develop relevant tools to assess this impact. Symptoms may include cold, numb and painful fingers, skin tightening, aching joints, ulcers and swollen hands. This study, from France, aimed to develop and validate a patient-reported outcome measure (a PROM) to assess hand involvement, the Hand scleroDerma lived Experience (HAnDE) scale. First, we conducted a study with 21 patients with systemic sclerosis to explore their lived experience of hand involvement. This phase led to the generation of an 18-item provisional scale based on what the participants had said. Then, we undertook a validation study of the HAnDE scale with 105 patients to ensure that the scale is reliable, consistent and robust enough to be used in future research and daily clinical practice. The HAnDE scale appears to be a useful tool for researchers and clinicians to assess all the dimensions of living with hand involvement in patients with systemic sclerosis. Linked Article: Sibeoni et al. Br J Dermatol 2022; 186:96–105.
TIM-3 blockade enhances IL-12-dependent antitumor immunity by promoting CD8<sup>+</sup>T cell and XCR1<sup>+</sup>dendritic cell spatial co-localization
Authors: Alycia Gardner, Álvaro de Mingo Pulido, Kay Hänggi, Sarah Bazargan, Alexis Onimus, Agnieszka Kasprzak, Jose R Conejo-Garcia, Katarzyna A Rejniak, Brian Ruffell
Journal: Journal for ImmunoTherapy of Cancer (2022)

Background T cell immunoglobulin and mucin domain containing−3 (TIM-3) blocking antibodies are currently being evaluated in clinical trials for solid and hematological malignancies. Despite its identification on T cells, TIM-3 is predominantly expressed by myeloid cells, including XCR1 + type I conventional dendritic cells (cDC1s). We have recently shown that TIM-3 blockade promotes expression of CXCR3 chemokine ligands by tumor cDCs, but how this drives a CD8 + T cell-dependent response to therapy is unclear. Methods T cell infiltration, effector function, and spatial localization in relation to XCR1 + cDC1s were evaluated in a murine orthotopic mammary carcinoma model during response to TIM-3 blockade and paclitaxel chemotherapy. Mixed bone marrow chimeras and diphtheria toxin depletion were used to determine the role of specific genes in cDC1s during therapeutic responses. Results TIM-3 blockade increased interferon-γ expression by CD8 + T cells without altering immune infiltration. cDC1 expression of CXCL9, but not CXCL10, was required for response to TIM-3 blockade. CXCL9 was also necessary for the increased proximity observed between CD8 + T cells and XCR1 + cDC1s during therapy. Tumor responses were dependent on cDC1 expression of interleukin-12, but not MHCI. Conclusions TIM-3 blockade increases exposure of intratumoral CD8 + T cells to cDC1-derived cytokines, with implications for the design of therapeutic strategies using antibodies against TIM-3.
Tumor-derived extracellular vesicles as messengers of natural products in cancer treatment
Authors: Yuanxin Xu, Kuanhan Feng, Huacong Zhao, Liuqing Di, Lei Wang, Ruoning Wang
Journal: Theranostics (2022)

Extracellular vesicles (EVs) are kinds of two-layer vesicles secreted by cells.They play significant roles in mediating component exchange between cells, signal transduction, and pathological development.Among them, the tumor-derived EVs (TDEVs) are found related to the tumor microenvironment and cancer development.TDEVs can be designed as a natural drug carrier with high tumor targeting and permeability.In recent years, drug delivery systems (DDS) based on TDEVs for cancer treatments have received considerable attention.In this review, the biological characteristics of TDEVs are introduced, especially the effect on the tumor.Furthermore, the various approaches to constructing DDS based on TDEVs are summarized.Then we listed examples of TDEVs successfully constructing treatment systems.The use of chemical drugs, biological drugs, and engineered drugs as encapsulated drugs are respectively introduced, particularly the application progress of active ingredients in traditional Chinese medicine.Finally, this article introduces the latest clinical research progress, especially the marketed preparations and challenges of clinical application of TDEVs.
Abstract 320: Apoa1 Binding Protein Regulates Lymphangiogenesis by Control of Caveolin-1
Authors: Renfang Mao
Journal: Circulation Research (2017)

ApoA-1 binding protein (AIBP) plays a vital role in zebrafish angiogenesis by targeting cholesterol effux, which reduces caveolae abundance, inhibits VEGFR2 activation. Although reduced caveolae abundance often attenuates receptor signaling, it has not bee studied whether AIBP affects VEGFR3 signaling and then plays a role in lymphangiogenesis. Thus, we studied the experesion of AIBP in lymphedema patients skin tissue. Interestingly, we found increased AIBP experession in human lymphedematous tissue and it is expressed in the lymphatic vessels as perilymphatic distribution, which indicated that AIBP plays a role in lymphangiogenesis. We then generated Aibp -/- mice, which are viable and fertile and compared dermal lymphatic development in Aibp -/- mice and wild-type control mice by whole mount immunostaining. Our data show that AIBP deficiency in mice results in significantly decreased lymphangiogenesis. In vitro lymphangiogenesis also show that AIBP/apoA1 significantly promote human lymphatic endothelia cell (HLEC) tube formation. These data suggeste that caveolae abundance controls lymphangiogenesis. Because caveolin1, a core protein in caveolae, inhibits VEGFR3 signaling, we thus determined the effect of cav1 deficiency, which results in loss of caveolae, on HLEC tube formation and showed cav1 knockdown promotes tube formation. We also found that VEGFR3 located in caveolae and binds to cav1 in LEC. What’s more, MβCD, which disrupts caveolae by sequestering cholesterol, enhances VEGFR3 activation. Therefore, our study demonstrated that AIBP promotes lymphangiogenesis. Mechanically, AIBP enhances cholesterol efflux from HLEC to apoA1, which might disrupt caveolae and then abolish cav1 inhibition of VEGFR3 signaling in lymphangiogenesis.
Associations of Childhood and Perinatal Blood Metals with Children’s Gut Microbiomes in a Canadian Gestation Cohort
Authors: Yike Shen, Hannah E. Laue, Martha J. Shrubsole, Haotian Wu, Tessa R. Bloomquist, Annie Larouche, Kankan Zhao, Feng Gao, Amélie Boivin, Diddier Prada, Darel J. Hunting, Virginie Gillet, Larissa Takser, Andrea A. Baccarelli
Journal: Environmental Health Perspectives (2022)

The gut microbiome is important in modulating health in childhood. Metal exposures affect multiple health outcomes, but their ability to modify bacterial communities in children is poorly understood.
Death during Dental Anaesthesia
Journal: BMJ (1974)

said: "This will be the much needed break- through for disenchanted consultants.Hos- pital staffs know that the British Medical Association has for some time been pressing for a complete reappraisal of the consultants' contract by setting up a working party for this purpose.We welcome the fact that the Government has recognized the strength of our argument and we look forward to co- operating to the full."We know that the working
Loperamide in acute diarrhoea in childhood: results of a double blind, placebo controlled multicentre clinical trial. Diarrhoeal Diseases Study Group (UK).
Authors: P Evans, R Hendrickse, C Taylor
Journal: BMJ (1984)

A total of 315 young children with acute diarrhoea were included in a double blind, hospital based multicentre trial of loperamide at two dose levels (0.8 mg and 0.4 mg/kg/24 h), given with standard oral rehydration therapy versus placebo plus oral rehydration therapy. The overall recovery rate was slowest in the placebo group and fastest in the group given loperamide 0.8 mg. Comparisons between weights on admission and weights by day 3 showed that a larger proportion of children in the loperamide groups gained weight than in the placebo group. No serious side effects of loperamide were observed, but the drug was withdrawn in one infant because of mild abdominal distention. The results indicate that loperamide, in the doses employed, is safe and may in selected cases be a useful adjunct to oral rehydration in the management of acute diarrhoea in well nourished children.
Oncostatin M expression induced by bacterial triggers drives airway inflammatory and mucus secretion in severe asthma
Authors: Sarah E. Headland, Hart S. Dengler, Daqi Xu, Grace Teng, Christine Everett, Rojo A. Ratsimandresy, Donghong Yan, Jing Kang, Kirthana Ganeshan, Evgeniya V. Nazarova, Sarah Gierke, Christopher J. Wedeles, Riccardo Guidi, Daryle J. DePianto, Katrina B. Morshead, Alison Huynh, Jessica Mills, Sean Flanagan, Shannon Hambro, Victor Nunez, Joanna E. Klementowicz, Yongchang Shi, Jianyong Wang, Jack Bevers, Vladimir Ramirez-Carrozzi, Rajita Pappu, Alex Abbas, Jason Vander Heiden, David F. Choy, Rajbharan Yadav, Zora Modrusan, Reynold A. Panettieri, Cynthia Koziol-White, William F. Jester, Brendan J. Jenkins, Yi Cao, Christine Clarke, Cary Austin, Daniel Lafkas, Min Xu, Paul J. Wolters, Joseph R. Arron, Nathaniel R. West, Mark S. Wilson
Journal: Science Translational Medicine (2022)

Bacterial-associated LPS drives oncostatin M–dependent airway inflammation and mucus hypersecretion in severe asthma.