tbuckley/cabot-search huggingface dataset:
TGF-β1 potentiates Vγ9Vδ2 T cell adoptive immunotherapy of cancer
Authors: Richard E. Beatson, Ana C. Parente-Pereira, Leena Halim, Domenico Cozzetto, Caroline Hull, Lynsey M. Whilding, Olivier Martinez, Chelsea A. Taylor, Jana Obajdin, Kim Ngan Luu Hoang, Benjamin Draper, Ayesha Iqbal, Tom Hardiman, Tomasz Zabinski, Francis Man, Rafael T.M. de Rosales, Jinger Xie, Fred Aswad, Daniela Achkova, Chung-Yang Ricardo Joseph, Sara Ciprut, Antonella Adami, Helge G. Roider, Holger Hess-Stumpp, Balázs Győrffy, Jelmar Quist, Anita Grigoriadis, Anette Sommer, Andrew N.J. Tutt, David M. Davies, John Maher
Journal: Cell Reports Medicine (2021)

Despite its role in cancer surveillance, adoptive immunotherapy using γδ T cells has achieved limited efficacy. To enhance trafficking to bone marrow, circulating Vγ9Vδ2 T cells are expanded in serum-free medium containing TGF-β1 and IL-2 (γδ[T2] cells) or medium containing IL-2 alone (γδ[2] cells, as the control). Unexpectedly, the yield and viability of γδ[T2] cells are also increased by TGF-β1, when compared to γδ[2] controls. γδ[T2] cells are less differentiated and yet display increased cytolytic activity, cytokine release, and antitumor activity in several leukemic and solid tumor models. Efficacy is further enhanced by cancer cell sensitization using aminobisphosphonates or Ara-C. A number of contributory effects of TGF-β are described, including prostaglandin E
Acute Myeloid Leukemia Case after Gene Therapy for Sickle Cell Disease
Authors: Sunita Goyal, John Tisdale, Manfred Schmidt, Julie Kanter, Jennifer Jaroscak, Dustin Whitney, Hans Bitter, Philip D. Gregory, Geoffrey Parsons, Marianna Foos, Ashish Yeri, Maple Gioia, Sarah B. Voytek, Alex Miller, Jessie Lynch, Richard A. Colvin, Melissa Bonner
Journal: New England Journal of Medicine (2021)

Gene therapy with LentiGlobin for sickle cell disease (bb1111, lovotibeglogene autotemcel) consists of autologous transplantation of a patient's hematopoietic stem cells transduced with the BB305 lentiviral vector that encodes the βA-T87Q-globin gene. Acute myeloid leukemia developed in a woman approximately 5.5 years after she had received LentiGlobin for sickle cell disease as part of the initial cohort (Group A) of the HGB-206 study. An analysis of peripheral-blood samples revealed that blast cells contained a BB305 lentiviral vector insertion site. The results of an investigation of causality indicated that the leukemia was unlikely to be related to vector insertion, given the location of the insertion site, the very low transgene expression in blast cells, and the lack of an effect on expression of surrounding genes. Several somatic mutations predisposing to acute myeloid leukemia were present after diagnosis, which suggests that patients with sickle cell disease are at increased risk for hematologic malignant conditions after transplantation, most likely because of a combination of risks associated with underlying sickle cell disease, transplantation procedure, and inadequate disease control after treatment. (Funded by Bluebird Bio.).
US, Canada, and UK Collaborate on New Guidance for Machine Learning
Authors: Rebecca Voelker
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ponatinib and Chemotherapy in Adults with <i>De Novo</i> Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia. Final Results of Ponalfil Clinical Trial
Authors: Josep-Maria Ribera, Olga Garcia, Jordi Ribera, Pau Montesinos, Isabel Cano, Pilar Martínez, Jordi Esteve, Daniel Esteban, María García-Fortes, Natalia Alonso, José González-Campos, Arancha Bermúdez, Anna Torrent, Eulàlia Genescà, Santiago Mercadal, Joaquín Martínez-López, Ramon Garcia-Sanz
Journal: Blood (2021)
Abstract 14159: Characteristics and Outcomes in COVID-19 Pediatric In-Hospital Cardiac Arrest Patients
Authors: Kasper G Lauridsen, Todd Sweberg, Sarah E Haskell, Orsola Gawronski, Dana E Niles, Maya Dewan, Sophie Skellett, Jordan M Duval-arnould, Gabriella Bottari, Vinay M Nadkarni, Anita Sen
Journal: Circulation (2021)

Introduction: Survival of adult patients with COVID-19 who had an in-hospital cardiac arrest (IHCA) are poor. Characteristics and outcomes for pediatric IHCA patients with COVID-19 are unknown. Hypothesis: We hypothesized that pediatric COVID-19 patients would have worse survival outcomes when compared to non-COVID patients. Methods: A multicenter, multinational cohort of pediatric IHCA in the pediRES-Q collaborative were reviewed (March 1, 2020 - April 1, 2021). We characterized patients with COVID-19 compared to patients without COVID-19 and investigated whether COVID-19 was associated with survival outcomes using multivariate logistic regression with mixed effects. Results: We identified 362 pediatric IHCAs of which 14 were COVID-19 positive. For non-COVID-19 vs COVID-19 patients respectively, median [Q1; Q3] age was 1.0 [0.3; 7.1] vs. 7.1 [1.5; 14.0] years and 42% vs. 43% were female. Immediate cause of arrest was hypotension: 8% vs. 43%, respiratory decompensation: 19% vs. 21%, and hypoxia 22% vs. 36% for non-COVID-19 vs. COVID-19 patients. For non-COVID-19 vs COVID-19 patients, total CPR duration was 10 [4; 33] min vs 19 [5; 33] min (for non-return of spontaneous circulation (ROSC) cases only: 35 [20; 55] min vs 34 [24; 34] min). For non-COVID-19 vs COVID-19 patients, ROSC was 79% vs. 57%, aOR: 0.48 (95% CI: 0.24-0.98), survival to hospital discharge was 45% vs. 29%, aOR: 0.63 (95% CI: 0.25-1.57) and survival with favorable neurological outcome was 39% vs. 21%, aOR: 0.51 (95% CI: 0.16-1.65). Conclusions: In a pediatric resuscitation quality improvement collaborative, pediatric IHCA patients with COVID-19 were older when compared to non-COVID-19 patients. Median CPR duration was &gt;30 minutes for COVID-19 non-survivors, COVID-19 patients had lower chance of ROSC when compared to non-COVID-19 patients but considerably better survival outcomes than those reported for adults.
Antiadenovirus Antibodies Predict Response Durability to Nadofaragene Firadenovec Therapy in BCG-unresponsive Non–muscle-invasive Bladder Cancer: Secondary Analysis of a Phase 3 Clinical Trial
Authors: Anirban P. Mitra, Vikram M. Narayan, Sharada Mokkapati, Tanner Miest, Stephen A. Boorjian, Mehrdad Alemozaffar, Badrinath R. Konety, Neal D. Shore, Leonard G. Gomella, Ashish M. Kamat, Trinity J. Bivalacqua, Jeffrey S. Montgomery, Seth P. Lerner, J. Erik Busby, Michael Poch, Paul L. Crispen, Gary D. Steinberg, Anne K. Schuckman, Tracy M. Downs, Robert S. Svatek, Joseph Mashni, Brian R. Lane, Thomas J. Guzzo, Gennady Bratslavsky, Lawrence I. Karsh, Michael E. Woods, Gordon A. Brown, Daniel Canter, Adam Luchey, Yair Lotan, Tracey Krupski, Brant A. Inman, Michael B. Williams, Michael S. Cookson, Kirk A. Keegan, Gerald L. Andriole, Alexander I. Sankin, Alan Boyd, Michael A. O'Donnell, Richard Philipson, Seppo Ylä-Herttuala, David Sawutz, Nigel R. Parker, David J. McConkey, Colin P.N. Dinney
Journal: European Urology (2021)
Erratum to: Hippocampal avoidance whole-brain radiotherapy without memantine in preserving neurocognitive function for brain metastases: a phase II blinded randomized trial
Authors: Wen-Chi Yang, Ya-Fang Chen, Chi-Cheng Yang, Pei-Fang Wu, Hsing-Min Chan, Jenny Ling-Yu Chen, Guann-Yiing Chen, Jason Chia-Hsien Cheng, Sung-Hsin Kuo, Feng-Ming Hsu
Journal: Neuro-Oncology (2021)
Crystalloid Composition and Rate of Fluid Administration When Resuscitating Patients in the Intensive Care Unit—Reply
Authors: Craig M. Coopersmith, Michael J. Connor
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lung Cancer in Nepal
Authors: Ramila Shilpakar, Bishnu Dutta Paudel, Rajeev Sharma, Sudhir Raj Silwal, Ranjan Sapkota, Prajowl Shrestha, Soniya Dulal, Madan Kumar Piya, Sampurna Man Tuladhar, Prakash Neupane, Meghnath Dhimal, Abesh Niroula, Dipesh Uprety
Journal: Journal of Thoracic Oncology (2021)
Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1
Authors: Piao Luo, Dandan Liu, Qian Zhang, Fan Yang, Yin-Kwan Wong, Fei Xia, Junzhe Zhang, Jiayun Chen, Ya Tian, Chuanbin Yang, Lingyun Dai, Han-Ming Shen, Jigang Wang
Journal: Acta Pharmaceutica Sinica B (2021)

Ferroptosis is a form of regulated cell death, characterized by excessive membrane lipid peroxidation in an iron- and ROS-dependent manner. Celastrol, a natural bioactive triterpenoid extracted from Tripterygium wilfordii, shows effective anti-fibrotic and anti-inflammatory activities in multiple hepatic diseases. However, the exact molecular mechanisms of action and the direct protein targets of celastrol in the treatment of liver fibrosis remain largely elusive. Here, we discover that celastrol exerts anti-fibrotic effects via promoting the production of reactive oxygen species (ROS) and inducing ferroptosis in activated hepatic stellate cells (HSCs). By using activity-based protein profiling (ABPP) in combination with bio-orthogonal click chemistry reaction and cellular thermal shift assay (CETSA), we show that celastrol directly binds to peroxiredoxins (PRDXs), including PRDX1, PRDX2, PRDX4 and PRDX6, through the active cysteine sites, and inhibits their anti-oxidant activities. Celastrol also targets to heme oxygenase 1 (HO-1) and upregulates its expression in activated-HSCs. Knockdown of PRDX1, PRDX2, PRDX4, PRDX6 or HO-1 in HSCs, to varying extent, elevated cellular ROS levels and induced ferroptosis. Taken together, our findings reveal the direct protein targets and molecular mechanisms via which celastrol ameliorates hepatic fibrosis, thus supporting the further development of celastrol as a promising therapeutic agent for liver fibrosis.
Tackling population health challenges as we build back from the pandemic
Authors: Gerry McCartney, Margaret Douglas, Martin Taulbut, S Vittal Katikireddi, Martin McKee
Journal: BMJ (2021)

No amount of positive spin can detract from the numbers.The UK has not done well in the pandemic, whether measured in terms of mortality, 1 economic performance, 2 or social protection.This should not have happened.In 2019, the UK came in second place in the Global Health Security Index. 3Yet, when the pandemic arrived, decision making was confused and slow, 4 existing structures were sidelined, and new ones, exemplified by the "eye wateringly expensive" test and trace system, 5 were flawed by design, paying inadequate attention to the needs of those isolating. 6Weak social safety nets offered little support.
Error in the Abstract
Authors: Wenjie Ma, Mingyang Song, Andrew Chan, Arpit Chhabra
Journal: JAMA Oncology (2021)

Kevin Kalinsky, MD, MS; Fangxin Hong, PhD; Carolyn K. McCourt, MD; Jasgit C. Sachdev, MD; Edith P. Mitchell, MD; James A. Zwiebel, MD; L. Austin Doyle, MD; Lisa M. McShane, PhD; Shuli Li, PhD; Robert J. Gray, PhD; Larry V. Rubinstein, PhD; David Patton, MD; Paul M. Williams, PhD; Stanley R. Hamilton, MD; Barbara A. Conley, MD; Peter J. O’Dwyer, MD; Lyndsay N. Harris, MD; Carlos L. Arteaga, MD; Alice P. Chen, MD; Keith T. Flaherty, MD
Reconstituted HDL-apoE3 promotes endothelial cell migration through ID1 and its downstream kinases ERK1/2, AKT and p38 MAPK
Authors: Eftaxia-Konstantina Valanti, Katerina Dalakoura-Karagkouni, Panagiotis Fotakis, Elizabeth Vafiadaki, Christos S. Mantzoros, Angeliki Chroni, Vassilis Zannis, Dimitris Kardassis, Despina Sanoudou
Journal: Metabolism (2021)
Exosomes-loaded thermosensitive hydrogels for corneal epithelium and stroma regeneration
Authors: Qiaomei Tang, Bing Lu, Jian He, Xiao Chen, Qiuli Fu, Haijie Han, Chenqi Luo, Houfa Yin, Zhenwei Qin, Danni Lyu, Lifang Zhang, Min Zhou, Ke Yao
Journal: Biomaterials (2021)
Comparison of Current and Enhanced Risk Stratification of 21,199 Children, Adolescents, and Young Adults with Acute Lymphoblastic Leukemia Using Objective Risk Categorization Criteria: A Children's Oncology Group Report
Authors: Natalie Delrocco, Mignon L. Loh, Michael Borowitz, Karen R Rabin, Patrick A Zweidler-McKay, Kelly W Maloney, Leonard A. Mattano, Eric C Larsen, Anne L Angiolillo, Reuven J Schore, Michael J. Burke, Wanda L Salzer, Brent L. Wood, Andrew J Carroll, Nyla A. Heerema, Shalini C Reshmi, Julie M Gastier-Foster, Richard C Harvey, I-Ming L Chen, Kathryn G Roberts, Charles G. Mullighan, Cheryl L Willman, Naomi J Winick, William L. Carroll, Stephen P. Hunger, Elizabeth A. Raetz, Meenakshi Devidas, John Kairalla
Journal: Blood (2021)
Improvement of Cutaneous Hereditary Hemorrhagic Telangiectasia With Pazopanib—A Multikinase Inhibitor
Authors: June Young Moon, Etsubdenk M. Ajebo, James R. Gossage, Matthew D. Belcher
Journal: JAMA Dermatology (2021)

This case report describes a patient with hereditary hemorrhagic telangiectasia that was complicated by cutaneous telangiectasias, gastrointestinal arteriovenous malformations with bleeding, nosebleeds, and liver and pulmonary arteriovenous malformations.
<i>Erratum: Vol. 70, No. 42</i>
Journal: MMWR Morbidity and Mortality Weekly Report (2021)

on page 1474, in the second column, first continued paragraph, the sentence beginning on line 12 should have read, "Low or undetectable antigen levels in vaccine samples support the theory of a single diluent that might have been introduced during preparation, thereby reducing vaccine antigen levels found in tested predrawn syringes, though none of the four involved vaccines require reconstitution or dilution and company A did not report use of a diluent."
Exposing T Cell Secrets Inside and Outside the Thymus
Authors: Pamela J. Fink
Journal: Annual Review of Immunology (2021)

I've had serious misgivings about writing this article, because from living the experience day by day, it's hard to believe my accomplishments merit the attention. To skirt this roadblock, I forced myself to pretend I was in a conversation with my trainees, trying to distill the central driving forces of my career in science. The below chronicles my evolution from would-be astronaut/ballerina to budding developmental biologist to devoted T cell immunologist. It traces my work from a focus on intrathymic events that mold developing T cells into self–major histocompatibility complex (MHC)-restricted lymphocytes to extrathymic events that fine-tune the T cell receptor (TCR) repertoire and impose the finishing touches on T cell maturation. It is a story of a few personal attributes multiplied by generous mentors, good luck, hard work, perseverance, and knowing when to step down.
Standards for Objectivity and Reproducibility in High-Impact Developmental Studies—The COVID-19 Pandemic and Beyond
Authors: Moriah E. Thomason
Journal: JAMA Pediatrics (2021)

health.This recent change in legislation is a once-in-a-generation opportunity to advocate for an expanded Child Tax Credit that applies to families, particularly families with immigrant children and those with very low income, who would otherwise earn too little to qualify but could benefit substantially from these monthly payments.These Child Tax Credit payments are essential to addressing inequities in child health and to decrease the number of families experiencing poverty.We call on all pediatricians to implore legislators to make these changes to the Child Tax Credit a permanent part of the strategy to care for US children because it has been proven that the changes are associated with not only healthier children but also healthier parents and families.
Covid-19: Runny nose, headache, and fatigue are commonest symptoms of omicron, early data show
Authors: Gareth Iacobucci
Journal: BMJ (2021)

Covid-19: Runny nose, headache, and fatigue are commonest symptoms of omicron, early data show Gareth IacobucciThe UK government has been urged to update its list of symptoms for covid-19, after early data showed that cold-like symptoms were the most commonly reported by people with the new omicron variant.
Vincristine Sulfate Liposome Injection (VSLI, Marqibo®) in Combination with UK ALL-R3 Induction Chemotherapy for Children, Adolescents and Young Adults with Relapsed Acute Lymphoblastic Leukemia (ALL): A Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL) Consortium Trial
Authors: Nirali N. Shah, Eric S Schafer, Kenneth Matthew Heym, Andrew E. Place, Melissa A. Burns, Nathan Gossai, Peter Shaw, Michael J. Burke, Bill H. Chang, Michelle L. Hermiston, Reuven J Schore, Teresa Rushing, Paul F Jarosinski, Richard Sposto, Ellynore Florendo, Jemily Malvar, Yueh-Yun Chi, James A. Whitlock, Lewis B. Silverman, Deepa Bhojwani, Alan S. Wayne
Journal: Blood (2021)
Analysis of Attitudes About COVID-19 Contact Tracing and Public Health Guidelines Among Undocumented Immigrants in the US
Authors: Hye Young Choi, May Sudhinaraset
Journal: JAMA Network Open (2021)

We found that numerous questions in the Centers for Disease Control and Prevention's sample contact tracing script have the potential to elicit fear, discomfort, inaccuracies, or nonresponse among undocumented immigrants based on participant concerns about breach of information, protecting undocumented parents from deportation and language discrimination, and distrust in government agencies (Table 1).For example, both Asian and Latinx participants doubted the quality of language access that could be offered to their parents and said their parents' lack of DACA status, and thus greater vulnerability to deportation, made them reluctant to share information on their parents' behalf.Participants also described a lack of resources to follow referrals or recommendations to access health care, quarantine, and negotiate work-based leave policies with employers.For example, when asked about informing employers about incident COVID-19 symptoms, participants mentioned they were denied sick leave or were immediately fired and felt financial pressure to keep working.We found considerable discordance between public health guidelines and undocumented immigrants' retrospective or prospective abilities to follow the guidelines because of lack of access to immigrantfriendly health care, limited space to quarantine, low neighborhood assets, job insecurity, and lack of employee benefits and workplace protections (Table 2).Table 1.Participant Responses to Questions From the Centers for Disease Control and Prevention Sample Contact Tracing Script
The role of cellular senescence in female reproductive aging and the potential for senotherapeutic interventions
Authors: Laura Secomandi, Michela Borghesan, Michael Velarde, Marco Demaria
Journal: Human Reproduction Update (2021)

Advanced maternal age is associated with decreased oocyte quantity and quality as well as uterine and placental dysfunctions. These changes lead to infertility, pregnancy complications and birth defects in the offspring. As the mean age of giving birth is increasing worldwide, prevention of age-associated infertility and pregnancy complications, along with the more frequent use of ART, become extremely important. Currently, significant research is being conducted to unravel the mechanisms underlying female reproductive aging. Among the potential mechanisms involved, recent evidence has suggested a contributing role for cellular senescence, a cellular state of irreversible growth arrest characterized by a hypersecretory and pro-inflammatory phenotype. Elucidating the role of senescence in female reproductive aging holds the potential for developing novel and less invasive therapeutic measures to prevent or even reverse female reproductive aging and increase offspring wellbeing.
Covid-19: Omicron is causing more infections but fewer hospital admissions than delta, South African data show
Authors: Owen Dyer
Journal: BMJ (2021)

Covid-19: Omicron is causing more infections but fewer hospital admissions than delta, South African data show Owen DyerData from South Africa's largest private health insurer suggest that omicron is spreading faster than any previous coronavirus variant and showing signs of immune escape, with both vaccinated and previously infected people more at risk than in previous waves.More than 90% of newly sequenced infections in South Africa now involve the omicron variant, and as it displaced delta, vaccine effectiveness dipped, revealed data presented by the insurer Discovery Health at a 14 December briefing. 11 Analysis of omicron outbreak based on 211 000 covid-19 test results in South Africa.Discovery Health.14 December 2021.www.discovery.co.za/corporate/news-room. 2 HKUMed finds Omicron SARS-CoV-2 can infect faster and better than delta in human bronchus but with less severe infection in lung.15 December 2021.