tbuckley/cabot-search huggingface dataset:
Two-dimensional echocardiographic assessment of Ebstein's anomaly.
Authors: T APorts, N HSilverman, N BSchiller
Journal: Circulation (1978)

Nine patients with Ebstein's anomaly of the tricuspid valve were studied by two-dimensional echocardiography, using the standard long and short axis views as well as the apex four chamber view. With this latter view, the displacement of the tricuspid valve into the right ventricle was clearly seen in all nine cases of Ebstein's anomaly and was not noted in a control population. The severity of the tricuspid displacement was assessed by comparing the position of the mitral and tricuspid valves relative to the cardiac apex. The apex four chamber view allowed visualization of the atrioventricular (AV) ring simultaneously with the displaced tricuspid valve, and therefore the size of the atrialized right ventricle, true right ventricle and right atrium could be determined. These dimensions compared favorably with angiography.
Annals Story Slam - Voices of Medical Students and Residents: What Can Be Done to Build Trust
Authors: Andrew Ikhyun Kim
Journal: Annals of Internal Medicine (2020)

Web Exclusives18 February 2020Annals Story Slam - Voices of Medical Students and Residents: What Can Be Done to Build TrustFREEAndrew Ikhyun KimAndrew Ikhyun KimUniversity of California, San Francisco, San Francisco, California (A.I.K.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/W20-0012 SectionsAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Video. Annals Story Slam - Voices of Medical Students and Residents: What Can Be Done to Build Trust "Voices of Medical Students and Residents: What Can Be Done to Build Trust," by Andrew Ikhyun Kim (Duration 4:32)Building on the popular Annals feature “On Being a Doctor,” storytellers share stories about the experience of doctoring on video.For more videos from and information on Annals Story Slam, visit go.annals.org/StorySlam. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: University of California, San Francisco, San Francisco, California (A.I.K.)Current Author Address: Andrew Ikhyun Kim; e-mail, andrew.[email protected]edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Relationship of Cobalamin and/or Folate to the Patient-Centred Outcomes in Multiple Sclerosis: A Systematic Review and Meta-analysis 18 February 2020Volume 172, Issue 4Page: SS1 ePublished: 18 February 2020 Issue Published: 18 February 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.Loading ...
Left atrial enlargement. Echocardiographic assessment of electrocardiographic criteria.
Authors: A DWaggoner, A VAdyanthaya, M AQuinones, J KAlexander
Journal: Circulation (1976)

A comparison of electrocardiographic manifestations of left atrial enlargement (LAE) and left atrial size by echocardiography was made in 307 patients in sinus rhythm. Electrocardiographic criteria used were L:P wave duration in lead II equal to or greater than 0.12 sec; Va: the ratio of the duration of negative terminal P in V1 to the P-R segment equal to or greater than 1.0; Vb: a negative P terminal force in V1 less than -0.03 mm sec. The echocardiographic diagnosis of left atrial enlargement was based on 1) transverse dimension greater than 4.0 cm; or 2) a ratio of transverse atrial to transverse aortic root dimension greater than 1.17. In the presence of left atrial enlargement, a combination of criteria occurred more often than a single criterion. The overall predictive index of the electrocardiogram for left atrial enlargement was 63% (excluding criterion Vb raised probability to 80%); and that for absence of left atrial enlargement was 78%. The index of coarse versus fine fibrillary waves was unre...
Renin-angiotensin system inhibition in acute myocardial infarction in dogs. Effects on systemic hemodynamics, myocardial blood flow, segmental myocardial function and infarct size.
Authors: C SLiang, HGavras, JBlack, L GSherman, W BHood
Journal: Circulation (1982)

Acute left anterior descending coronary artery occlusion was produced in 21 conscious, chronically instrumented dogs. Forty minutes after coronary occlusion, nine dogs were given i.v. teprotide, 25 micrograms/kg/min, followed by oral doses of captopril, 10 mg/kg every 8 hours for 24 hours. The remaining 12 dogs served as saline-infused controls. In all dogs, acute coronary occlusion increased plasma renin activity and peripheral vascular resistance and reduced cardiac output, but did not change mean aortic blood pressure significantly. Teprotide significantly (p less than 0.05) decreased peripheral vascular resistance (from 3804 +/- 1158 to 2876 +/- 816 dy-sec-cm-5) (+/- SD) and mean aortic pressure (from 117 +/- 12 to 107 +/- 15 mm Hg), and increased cardiac output (from 2.63 +/- 0.67 to 3.12 +/- 0.74 l/min). Teprotide also produced a relative increase in flow to the renal and splanchnic circulations compared with the saline-treated controls. There were, however, no differences in segmental systolic shor...
Nicardipine prevents calcium loading and "oxygen paradox" in anoxic single rat myocytes by a mechanism independent of calcium channel blockade.
Authors: OHano, H SSilverman, P SBlank, E DMellits, RBaumgardner, E GLakatta, M DStern
Journal: Circulation Research (1991)

The protective effect of nicardipine (1 and 4 microM) against reoxygenation injury was studied in an unstimulated rat single myocyte oxygen paradox model in comparison with control (no drug) or nifedipine (1 microM). Either concentration of nicardipine was strongly protective, approximately doubling the duration of ATP depletion (rigor) that cells could withstand without undergoing hypercontracture when reoxygenated. Nifedipine (1 microM), which matched the negative inotropic effect of nicardipine (4 microM) (as measured by extent of shortening when stimulated), had no protective effect against reoxygenation injury. Neither drug affected the time to rigor, which is a measure of the rate at which the resting cell consumes its endogenous glycogen stores during anaerobic metabolism. Intracellular calcium, measured with the fluorescent probe indo-1, which partitions into both cytosol and mitochondria, rose progressively throughout the rigor period. This rise in calcium was almost totally suppressed by nicardi...
Prognostic implications of baseline electrocardiographic features and their serial changes in subjects with left ventricular hypertrophy.
Authors: DLevy, MSalomon, R BD'Agostino, A JBelanger, W BKannel
Journal: Circulation (1994)

BACKGROUNDDuring the past half-century, the ECG has been used extensively for the diagnosis of left ventricular hypertrophy. Persons with ECG evidence of left ventricular hypertrophy are at increased risk for the development of cardiovascular disease.METHODS AND RESULTSSubjects from the Framingham Heart Study with ECG evidence of left ventricular hypertrophy were eligible for this investigation if they were free of cardiovascular disease and did not have complete bundle-branch block or Wolff-Parkinson-White syndrome. Logistic regression analyses of pooled biennial examinations were used to determine risk for cardiovascular disease as a function of baseline voltage (sum of R wave in aVL plus S wave in V3) and repolarization and as a function of serial changes in these ECG features of hypertrophy. The eligible sample consisted of 274 men (mean age, 60 years) and 250 women (mean age, 64 years) who contributed 2660 person-examinations. During follow-up, there were 269 new cardiovascular events. Compared with ...
Clinical Characteristics and Prognosis of Patients with Non-Type 1 Brugada-Pattern Electrocardiogram and a History of Ventricular Fibrillation
Authors: Kamakura Tsukasa, Wada Mitsuru, Ishibashi Kohei, Inoue Yuko, Miyamoto Koji, Nagase Satoshi, Noda Takashi, Aiba Takeshi, Anzai Toshihisa, Noguchi Teruo, Yasuda Satoshi, Ogawa Hisao, Kamakura Shiro, Kusano Kengo
Journal: Circulation (2016)
Horizontal transmission of HTLV-1 causing uveitis
Authors: Koju Kamoi, Noe Horiguchi, Hisako Kurozumi-Karube, Isao Hamaguchi, Yoshihisa Yamano, Kaoru Uchimaru, Arinobu Tojo, Toshiki Watanabe, Kyoko Ohno-Matsui
Journal: The Lancet Infectious Diseases (2021)
Localization of beta 1- and beta 2-adrenergic receptors in rat kidney by autoradiography.
Authors: D PHealy, P AMünzel, P AInsel
Journal: Circulation Research (1985)

beta-Adrenergic receptor subtypes were localized and differentiated in rat kidney slices by in vitro autoradiography using the nonselective beta-antagonist [125I]iodocyanopindolol in the presence of the selective agents betaxolol (beta 1) and zinterol (beta 2). [125I]Iodocyanopindolol binding to kidney sections in the presence of these agents could be differentiated into high- and low-affinity components as predicted by the subtype selectivity of the compounds. Autoradiography revealed that: beta-adrenergic receptors were highly concentrated within the renal cortex, especially in glomeruli and juxtaglomerular granule cells, and to tubular sites in the cortex and medulla; [125I]iodocyanopindolol labeling of the juxtaglomeruluar granule cells was abolished at lower concentrations (10(-8) M) of betaxolol than was the labeling of glomeruli (10(-6)--10(-4) M); and zinterol had little effect on labeling of juxtaglomerular granule cells and glomeruli unless high concentrations were used, whereas the tubular labe...
3P AZ12756122, a novel fatty acid synthase (FASN) inhibitor, reduces resistance properties in gefitinib- and osimertinib-resistant EGFR-mutated non-small cell lung cancer models
Authors: E. Polonio, S. Palomeras, R. Porta-Balanya, J. Bosch-Barrera, C.A. Vásquez, J. Ciurana, S. Ruiz-Martínez, T. Puig
Journal: Journal of Thoracic Oncology (2021)
Congenital coronary arteriovenous fistula. Report of 13 patients, review of the literature and delineation of management.
Authors: R RLiberthson, KSagar, J PBerkoben, R MWeintraub, F HLevine
Journal: Circulation (1979)

Thirteen new patients and 174 patients previously reported with coronary arteriovenous fistula (CAVF) were reviewed to delineate the course and management of CAVF and to clarify the role of surgical ligation in the young asymptomatic patient. Patients were grouped according to age: 99 patients (four new and 95 reported) were less than 20 years old and 88 (nine new and 79 reported) were greater than or equal to 20 years old. Of those under 20 years of age, 19% had preoperative symptoms or CAVF-related complications, including congestive heart failure (CHF) in 6%, subacute bacterial endocarditis in 3% and death in one patient. Seventy-six patients younger than 20 years old had CAVF ligation with only one significant complication. In contrast, 63% of the older group and all of our nine older patients had preoperative symptoms or complications, including CHF in 19%, SBE in 4%, myocardial infarction (MI) in 9%, death in 14% and fistula rupture in one patient. Of the 43 ligated older patients, 23% had surgical ...
The course of the conduction system in dextrocardia.
Authors: SBharati, MLev
Journal: Circulation (1978)

This is a serial section examination of the conduction system of five hearts of various types of dextrocardia. In one case of dextroversion the conduction system was found to be normal. In one case of mirror-image dextrocardia the conduction system was normal but in the opposite spatial position. In one heart of mixed (discordant) dextrocardia, the sinoatrial node was in correct morphologic position. There were two atrioventricular nodes - a posterior node close to the coronary sinus and an anterior node in the roof of the morphologic right atrium. They formed two separate bundles which joined in the left ventricle to form a  In two cases of presumptive mirror-image dextrocardia, with a common atrium in situs inversus according to the morphology of the atrial appendages, with common atrioventricular orifice (CAVO), the sinoatrial node was situated in wrong positions. Two atrioventricular nodes and bundles again formed a sling. There are various types of slings in discordant dextrocardia.
Clinical pharmacokinetics and efficacy of amiodarone for refractory tachyarrhythmias.
Authors: C IHaffajee, J CLove, A TCanada, L JLesko, GAsdourian, J SAlpert
Journal: Circulation (1983)

Using a high-pressure liquid chromatographic assay, we measured serum amiodarone concentrations serially in 122 patients treated with amiodarone for 1.5-53 months (mean 9.3 months) for control of refractory symptomatic atrial or symptomatic and life-threatening ventricular tachyarrhythmias. The atrial tachyarrhythmias were successfully controlled in 45 of 54 patients (83%) during a mean follow-up of 10.0 months. In the ventricular tachyarrhythmia group, which included 22 survivors of sudden cardiac death, 38 of 50 patients (76%) responded to amiodarone during a mean follow-up of 10.9 months. Although the mean serum amiodarone concentration did not differ between responders and nonresponders, eight responders relapsed when their serum concentration fell below 1.0 mg/l. Side effects resulted in withdrawal of amiodarone in only 10 of 122 patients (9%) despite a 30% overall incidence of side effects. Central nervous system and gastrointestinal side effects became more frequent with serum concentrations greate...
Stimulation of fibroblast collagen and total protein formation by an endothelial cell-derived factor.
Authors: A GVillanueva, H WFarber, SRounds, R HGoldstein
Journal: Circulation Research (1991)

We investigated the effect of medium conditioned by bovine aortic endothelial cells on collagen accumulation and total protein formation by human embryonic fibroblasts or bovine smooth muscle cells in cultures. The conditioned medium at a 1:10 dilution induced a twofold increase in collagen and total protein accumulation in fibroblast cultures. At low concentration (1:50 dilution), the conditioned medium stimulated collagen accumulation preferentially; at high concentration (1:10 dilution), overall protein synthesis also was increased. The increase in type I collagen accumulation was associated with an increase in the steady-state level of alpha 1 (I) mRNA for collagen. The conditioned medium increased the production of types I and III collagen without affecting the proportion of collagen types in both fibroblast and smooth muscle cell cultures. Partial purification of the endothelial cell-derived factor disclosed it to be a heat-stable protein with an apparent molecular weight of 8-10 kDa. The stimulatio...
Prevalence of Hypertension Among Pregnant Women When Using the 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines and Association With Maternal and Fetal Outcomes
Authors: Natalie A. Bello, Hui Zhou, T. Craig Cheetham, Eliza Miller, Darios Getahun, Michael J. Fassett, Kristi Reynolds
Journal: JAMA Network Open (2021)

<h3>Importance</h3> Hypertensive disorders of pregnancy are a leading cause of maternal morbidity and mortality. The impact of applying recent guideline definitions for nonpregnant adults to pregnant women is unclear. <h3>Objective</h3> To determine whether reclassification of hypertensive status using the 2017 American College of Cardiology/American Heart Association (ACC/AHA) guideline definition better identifies women at risk for preeclampsia or eclampsia and adverse fetal/neonatal events compared with the current American College of Obstetricians and Gynecologists (ACOG) definition of hypertension. <h3>Design, Setting, and Participants</h3> This cohort study used electronic medical record data of women who delivered singleton infants between 2009 and 2014 at a large US regional health system. Data analysis was performed from July 2020 to September 2020. <h3>Exposure</h3> Application of ACC/AHA and ACOG guidelines for the definition of chronic and gestational hypertension. <h3>Main Outcomes and Measures</h3> The primary maternal end point was the development of preeclampsia or eclampsia, and the primary fetal/neonatal end point was a composite of preterm birth, small for gestational age, and neonatal intensive care unit admission within 28 days of delivery. Net reclassification indices were calculated to examine how well the lower ACC/AHA diagnostic threshold reclassifies outcomes of pregnancy compared with the current ACOG definition of hypertension. <h3>Results</h3> Applying the ACC/AHA criteria to 137 389 pregnancies of women (mean [SD] age at time of delivery, 30.1 [5.8] years) resulted in a 14.3% prevalence of chronic hypertension (19 621 pregnancies) and a 13.8% prevalence of gestational hypertension (18 998 pregnancies). A 17.8% absolute increase was found in the overall prevalence of hypertension from 10.3% to 28.1%. The 2.1% of women who were reclassified with chronic rather than gestational hypertension had the highest risk of developing preeclampsia compared with women without hypertension by either criterion (adjusted risk ratio, 13.58; 95% CI, 12.49-14.77). Overall, the use of the ACC/AHA criteria to diagnose hypertension resulted in a 20.8% improvement in the appropriate identification of future preeclampsia, but only a 3.8% improvement of appropriate fetal/neonatal risk classification. <h3>Conclusions and Relevance</h3> Using the lower diagnostic threshold for hypertension recommended in the 2017 ACC/AHA guideline increased the prevalence of chronic and gestational hypertension, markedly improved the appropriate identification of women who would go on to develop preeclampsia, and was associated with the identification of adverse fetal/neonatal risk.
Novel approach for enhancing atrioventricular nodal conduction delay mediated by endogenous adenosine.
Authors: CKollias-Baker, JXu, APelleg, LBelardinelli
Journal: Circulation Research (1994)

The 2-amino-3-benzoylthiophene derivative PD 81,723 potentiates the A1 receptor-mediated negative dromotropic effect of exogenous adenosine and adenosine receptor agonists in guinea pig isolated perfused and in situ hearts. The objective of this study was to determine whether PD 81,723 could amplify the cardiac actions of endogenous adenosine. Two approaches known to increase the myocardial interstitial concentration of adenosine--hypoxia, which increases the production of adenosine and the inhibition of adenosine kinase, which decreases its metabolism--were used to test this hypothesis. In guinea pig hearts in situ, PD 81,723 (2 mg/kg i.v.) potentiated the atrioventricular (AV) nodal conduction delay caused by hypoxemia (PaO2, 14 to 19 mm Hg). In guinea pig isolated hearts, PD 81,723 (5 mumol/L) increased by twofold the stimulus-to-His bundle (S-H) interval prolongations induced by both a 5-minute period of hypoxia (25% O2/70% N2/5% CO2) and the administration of the adenosine kinase inhibitor iodotuberc...
The neurological implication of the intervertebral foramen
Authors: S. R. Greenberg
Journal: JAMA (1979)

<h3>To the Editor.—</h3> It has always been our practice to determine serum calcium levels in patients who have undergone thyroid surgery to exclude the possibility of postsurgical hypoparathyroidism. In three cases, however, we were surprised to find hypercalcemia, after thyroid surgery, later demonstrated to be previously undetected hyperparathyroidism. We apprehensively advised parathyroid surgery in these three cases, knowing quite well that the risk of an unsuccessful operation is greater in patients with prior neck surgery. In one case, we elected to do parathyroid catheterization studies with differential parathyroid hormone determinations to accurately localize the lesion prior to surgery because the patient had severe angina. Fortunately, all three patients had successful parathyroid surgery with resumption of normal calcium values. Because of this experience, we have recently started to determine serum calcium values in all patients with thyroid nodules to exclude possible coexisting hyperparathyroidism prior to thyroid surgery. Recently, we encountered a
Extracellular and intracellular actions of adenosine and related compounds in the reperfused rat intestine.
Authors: P MKaminski, K GProctor
Journal: Circulation Research (1992)

By using pharmacological tools, the biological actions of adenosine (ADO) were manipulated in rat intestine that had been rendered ischemic for 5 or 15 minutes and reperfused for 1 or 24 hours. With 100 microM ADO topically administered for 30 minutes after ischemia and then washed out, intestinal arteriolar blood flow (BF) and tissue ATP were restored to preocclusion levels, and histological damage was minimal after 1 hour of reperfusion. For comparison, with vehicle treatment after ischemia, BF was reduced by 50%, tissue ATP was reduced by 50%, myeloperoxidase levels in the intestine and lung were increased at least twofold, and mucosal villi were shortened and thickened after 1 hour of reperfusion. Furthermore, with vehicle treatment, both baseline BF and reactivity to endothelium-dependent (acetylcholine) and endothelium-independent (2-chloroadenosine) vasodilators were significantly depressed after 24 hours of reperfusion. In contrast, with ADO, baseline BF remained near normal, and vascular reactivi...
Echographic determination of left ventricular volumes in pediatric patients.
Authors: R AMeyer, JStockert, SKaplan
Journal: Circulation (1975)

The purpose of this study was to validate the accuracy of determining left ventricular (LV) volumes by echocardiography in infants and children. Thirty-one patients between the ages of two months and 15 years underwent left ventriculography (biplane antero-posterior and lateral cine). Ventricular volumes using an ellipsoidal model were calculated for end diastole from the cineangiograms. There was a strong correlation (r = 0.856) between the echographic minor dimension (Be) and the minor lateral cine dimension (Bc) at end diastole. A similar correlation (r = 0.889) existed between the LV volume in end diastole measured by cineangiography and Be. The correlation coefficient between the echo minor dimension and the lateral minor cine dimension in end systole was 0.753. A relation between ejection fraction (EF) and the echo minor dimension measurements in end diastole and end systole was formulated, which permitted estimation of the EF from the echo measurements. As a result of this study, it was concluded t...