DICOUMAROL THERAPY
Authors: J B LEVAN
Journal: Annals of Internal Medicine (1946)

Article1 December 1946DICOUMAROL THERAPYJOHN B. LEVAN, M.D., F.A.C.P.JOHN B. LEVAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-25-6-941 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Excerpt1. This study discusses the factors concerned with dicoumarol therapy.2. The initial dosage and a practical way of estimating maintenance dosage are shown.3. The daily plasma prothrombin times, factors affecting them, and the need for dependable laboratory technic are emphasized.4. The variation in degree of response, the lag period, and the therapeutic level are discussed.5. Hemorrhage the only toxic manifestation of dicoumarol, is considered, and the methods of treatment are stated.6. The contraindications are listed.7. The results of therapy in 60 patients including 13 cases of pulmonary embolism are discussed.The rationale for dicoumarol...Bibliography1. DETAKATSFOWLER GEF: The problem of thrombo-embolism, Surgery, 1945, xvii, 153-157. Google Scholar2. SMITHALLEN LAEV: Vascular clinics. XIV: Studies on the rate of venous blood flow: Physiologic studies and relation to postoperative venous thrombosis and pulmonary embolism, Proc. Staff Meet. Mayo Clin., 1941, xvi, 53-56. Google Scholar3. VEALHUSSEY JRHH: Surgery of deep venous thrombosis of the lower extremity, Surgery, 1945, xvii, 218-231. Google Scholar4. REICHYAHREGGERSLIPKIN CMDCR: Dicoumarol in the prevention of postoperative thrombosis and embolism, Surgery, 1945, xviii, 238-243. Google Scholar5. HUNTERKRYGIERKENNEDYSNEEDEN WCJJJCVD: Etiology and prevention of thrombosis of the deep leg veins, Surgery, 1945, xvii, 178-190. Google Scholar6. EVANS JA: Anticoagulation therapy of postoperative venous thrombosis and pulmonary embolism, Surg. Clin. 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PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTHE SIGNIFICANCE OF HAEMORRHAGE DURING THE TREATMENT OF PATIENTS WITH THE COUMARIN ANTICOAGULANTSProblems and Practices in a Community HospitalThe erythrocyte sedimentation rate in human subjects receiving dicumarolAntagonism of Dicumarol by Vitamin K PreparationsPlasma prothrombin times in normal human subjects. The effect of certain factors on the prothrombin timeThromboembolism 1 December 1946Volume 25, Issue 6Page: 941-949KeywordsBlood plasmaHemorrhageProthrombin timePulmonary embolismResearch laboratories ePublished: 1 December 2008 Issue Published: 1 December 1946 PDF downloadLoading ...