tbuckley/cabot-search huggingface dataset:
Therapeutics
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
College of Surgeons, Ireland
Journal: BMJ (1841)

The Royal College of Surgeons of Edinburglh havitng transmitted a report on the proposed measure of AMedical Reform to the Roval College of Surgeons in Ireland, with4 a requiest that it should be considered, and if approved of; that the two colleges should cooperate to attain the ohject § contemplated-tlhe subject was referred to a commi ttee.''Ihis comniittee presented their report last week, recoin- mending that the college shQW4l unite with the college of Edinburgh in their efforts, and that the bill of Mr. War- buirton, with certain modifications, and certain portions of AMr.Ilawes's draft, should be suipported."
Diagnostic and Therapeutic Challenges for Infants with Radiosensitive (RS)-SCID Identified by Newborn Screening (NBS)
Authors: David Potts, Shannon Sullivan, Melis Yilmaz, Kady Palmer, Mary Ann Miranda, Priyanka Timothy, Carla Duff, Gretchen Vaughn, Gauri Sunkersett, Deepakbabu Chellapandian, Benjamin Oshrine, Panida Sriaroon, Stanton Goldman, Morton Cowan, Jennifer Puck, Roshini Abraham, Jennifer Leiding, Jolan Walter
Journal: Journal of Allergy and Clinical Immunology (2022)
Combined intense lifestyle and pharmacologic lipid treatment further reduce coronary events and myocardial perfusion abnormalities compared to usual care cholesterol loweing drugs in coronary artery disease
Authors: Stefano Sdringola, Keiichi Nakagawa, Yuko Nakagawa, Wamique S. Yusuf, Fernando Boccalandro, Nizar Mullani, Mary Haynie, Mary Jane Hess, K.Lance Gould
Journal: Journal of the American College of Cardiology (2003)
Use of Basophil Activation Test in Peach Allergy Diagnosis
Authors: José Cañas, Leticia Lopera-Doblas, Ana Molina, Natalia Pérez-Sánchez, Francisa Gómez, Francisca Palomares, Anyith Cruz-Amaya, Marina Labella, Carmen Rondón, Ibón Eguiluz-Gracia, María Torres, Cristobalina Mayorga
Journal: Journal of Allergy and Clinical Immunology (2022)
RITZ 5: R andomized intravenous T e Z osentan (an endothelin ET-A/B antagonist) for the treatment of pulmonary edema: a prospective multicenter double blind Placebo controlled study
Authors: Edo Kaluski, Reuven Tzimilchman, Alon Marmur, Oscar Krakov, Olga Milovanov, Avi Caspi, Zvi Vered, Gad Cotter
Journal: Journal of the American College of Cardiology (2002)
Bronchorrhea responsive to aerosolized atropine
Authors: M. M. Wick
Journal: JAMA (1976)

THE ROLE of parasympathetic stimulation of the tracheobronchial tree in the obstructive pulmonary disorders of asthma and chronic bronchitis has not been separated from the multiple factors involved in the pathophysiologic characteristics of these conditions. Parasympathetic stimulation results in constriction of bronchial smooth muscle and enhanced glandular secretory activity.<sup>1</sup>Occasionally, parasympatholytic agents have been used as bronchodilators but have been mainly avoided because of the potential danger of drying secretions. Most current bronchodilator therapy for obstructive airway disease is based on the use of sympathomimetic or methylxanthine agents or both. This report describes a patient with severe bronchorrhea as the primary manifestation of his obstructive airway disease. The prompt response to aerosolized atropine sulfate suggested that increased parasympathetic efferent activity was largely responsible for his bronchorrhea. <h3>Report of a Case</h3> A 54-year-old man was hospitalized for evaluation of a chronic productive cough of eight months' duration. The cough had
P106: EARLY PREVENTIVE DIAGNOSIS OF HEMOLYTIC ANEMIA IN SICKLE CELL PATIENTS BY DETECTING THE TRIGGERING OF ERYPTOSIS.
Authors: K Khalfaoui, I Moumni, M Chebbi, I Safra, M Barmate, D Chaouechi, M Benkhaled, M Ouederni, F Mellouli, S Menif
Journal: HemaSphere (2022)

Background/Aims: Sickle cell disease (SCD) also known as sickle cell anemia is one of the most worldwide-disseminated hereditary hemoglobinopathies. It is caused by a single amino acid substitution at the sixth residue of β globin gene (Glu6Val), which results in an abnormal hemoglobin called hemoglobin S (HbS). The acceleration of HbS polymerization induces rigid and dysfunctional erythrocytes that play a central role in acute and chronic clinical manifestations of SCD(Conran et al.,2009). Vaso-occlusion and hemolytic anemia are the hallmarks of SCD. We aim to explore the cellular environment of red blood cells to explain the physiopathology of SCD. In fact, the life span of circulating erythrocytes in healthy individuals vary from 100 to 120 days. In SCD, red blood cells undergo a form of cell death, namely, eryptosis before they reach their full life span. Eryptosis is triggered by a wide variety of factors as hyperosmolarity, oxidative stress and energy depletion. It is characterized by the presence of membrane blebbing, cell shrinkage, and phosphatidylserine (PS) exposure (Lang et al.,2012). In this study, we will explore the mechanism of triggering of eryptosis in Sickle cell disease. Methods: Following clinical diagnosis, 50 homozygous SCD patients and 30 healthy donors were identified for hematological and cellular assays. Flow cytometry was performed in order to determine the viability parameters of erythrocytes. The morphology of red blood cells and the externalization of phosphatidylserine was detected by labeling red blood cells with Annexine V. Moreover, we had identified intracellular calcium concentration and ceramide level by labeling erythrocytes with Fluo3-am and anti-ceramide antibodies. Finally, we had quantified reactive oxygen species (ROS) by labeling red blood cells with CM-H2DCFDA. Results and Discussion: Eryptosis in sickle cell patients is accelerated. In fact, PS (+) red blood cells are more present in patients than in healthy subjects. Therefore, eryptosis is triggered by oxidative stress, which stimulates the increase of calcium activity and subsequent externalization of PS and red blood cells shrinkage in sickle cell patients. However, the pathway of ceramide can also be considered a potential stimulating factor of eryptosis in SCD. Eryptosis ensures healthy erythrocyte quantity in circulation, whereas excessive eryptosis is the cause of acute anemia and may contribute to vaso-occlusive crisis in SCD patients. References 1. Conran et al, Hemoglobin 2009;33:1–16 2. Lang et al, Transfusion Medicine and Hemotherapy 2012; 39: 308
Airway Hyperresponsiveness and Eosinophilic Airway Inflammation In Patients With Atopic Dermatitis
Authors: Ruth Cusack, Christiane Whetstone, Karen Howie, Caitlin Stevens, Jennifer Wattie, Lesley Wiltshire, Paul O'Byrne, Roma Sehmi, Hermenio Lima
Journal: Journal of Allergy and Clinical Immunology (2022)
Non-Atopic Infants Have Distinct Plasma Cytokine Profiles Compared to Atopic Infants
Authors: Michael Phillips, Carolyn Baloh, Guglielmo Venturi, Bernard Fischer, Kristina De Paris, John Sleasman, Julie Kim-Chang
Journal: Journal of Allergy and Clinical Immunology (2022)

Discrete cytokine profiles in infancy have shown to predict development of atopy but biomarkers of non-atopic infants have not been established. A cohort of 82 healthy, vaginally delivered, term newborns were evaluated at birth, 6 months, and 12 months and monitored for development of atopic conditions (eczema, food allergy, allergic rhinitis and/or asthma) until age 5. Plasma levels of APRIL, BAFF, IL-2, sCD40L, IL-1β, IL-4, IL-17, IL-21, IL-22, IL-25, IL-31, IL-33, IFN-ɣ, sCD163, and sCD14 were measured using multiplex/ELISA assays. Cytokine levels were compared between study groups using unpaired nonparametric t test. A post hoc power analysis was conducted to determine sample size needed to reach significance. Clinical outcomes were available from 39 participants (48% of total enrolled), of whom 20 (51%) had evidence of atopy and 19 (49%) did not. While there was no significant difference in any of the biomarkers between atopic and non-atopic infants, IL-25, IFNγ, IL-21, and sCD163 showed differences approaching significance at 6 months (p = 0.06 - 0.08). An exploratory power analysis indicated that approximately 30 participants in each group are needed to detect meaningful differences between two groups for IL-25 and IFNγ, with an effect size 0.68, alpha 0.1, and power 0.8. In contrast, IL-21, and sCD163 had larger distribution and smaller effect sizes requiring samples of 50 to 60 per group. Early biomarkers of immunity can assess risk for atopic conditions, even with small sample sizes. Infants without atopy need to be included as a comparison group to establish reference ranges.
Pulmonary function characteristics in children with symptoms of asthma and its implications for asthma diagnosis
Authors: Mireu Park, Yun Young Roh, Ha Min Kim, Jae Hwa Jung, Soo Yeon Kim, Jong Deok Kim, Yong Ju Lee, Min Jung Kim, Yoon Hee Kim, Kyung Won Kim, Myung Hyun Sohn
Journal: Journal of Allergy and Clinical Immunology (2022)
Reducing errors in guided implant surgery to optimize treatment outcomes
Authors: Tali Chackartchi, Georgios E. Romanos, Laszlo Parkanyi, Frank Schwarz, Anton Sculean
Journal: Periodontology 2000 (2022)

Abstract Clinical considerations and treatment criteria in implant placement are constantly evolving. Prosthetically driven implant surgery has become the standard of care to improve short and long‐term functional and esthetic outcomes. Therefore, implant position and angulation are planned according to the available bone, anatomical structures, and the requirements of the future prosthetic superstructure. In parallel with these developments, significant progress has been made in data imaging and different software technologies to allow the integration of data within a digital file format. Digitalization in implant surgery enables optimal planning of implant position, as well as the ability to transfer this planning to the surgical field—a process defined as “computer‐supported implant planning and guided surgery.” The aims of the present review are as follows: (a) to critically appraise the indications and potential “added value” of guided implant surgery, elaborating the main differences between dynamic and static guidance; and (b) to discuss the most important clinical considerations relevant for the different steps of the workflow that might influence the surgical outcome and to offer recommendations on how to avoid or reduce process errors in order to optimize treatment outcomes.
The Mechanism of the Larynx.
Journal: JAMA (1930)

This is the report, if one may so term it, of a stupendous research conducted over a period of ten years. There is a foreword by Dr. Max A. Goldstein of St. Louis, with an introduction by Sir Arthur Keith, conservator of the museum, Royal College of Surgeons of England, in whose laboratory the work was done. The author states expressly that his description of the mechanism of the larynx as set forth is purely unconnected, and not a research into the causes of pathologic disturbances of the human organ or as an aid to the singing master. To him it seems of the greatest interest to make this study from a biologic point of view and to consider man merely in his right place; namely, as a member of the animal kingdom. At the end of the book, however, a summary is given of the structure and function of
Antithrombotic Therapy in Patients With Atrial Fibrillation After Acute Coronary Syndromes or Percutaneous Intervention
Authors: Ralf E. Harskamp, Alexander C. Fanaroff, Renato D. Lopes, Daniel M. Wojdyla, Shaun G. Goodman, Laine E. Thomas, Ronald Aronson, Stephan Windecker, Roxana Mehran, Christopher B. Granger, John H. Alexander
Journal: Journal of the American College of Cardiology (2022)
Functional gastroduodenal disorders
Authors: N J Talley, V Stanghellini, R C Heading, K L Koch, J R Malagelada, G N J Tytgat
Journal: Gut (1999)

While widely used in research, the 1991 Rome criteria for the gastroduodenal disorders, especially symptom subgroups in dyspepsia, remain contentious. After a comprehensive literature search, a consensus-based approach was applied, supplemented by input from international experts who reviewed the report. Three functional gastroduodenal disorders are defined. Functional dyspepsia is persistent or recurrent pain or discomfort centered in the upper abdomen; evidence of organic disease likely to explain the symptoms is absent, including at upper endoscopy. Discomfort refers to a subjective, negative feeling that may be characterized by or associated with a number of non-painful symptoms including upper abdominal fullness, early satiety, bloating, or nausea. A dyspepsia subgroup classification is proposed for research purposes, based on the predominant (most bothersome) symptom: (<i>a</i>) ulcer-like dyspepsia when pain (from mild to severe) is the predominant symptom, and (<i>b</i>) dysmotility-like dyspepsia when discomfort (not pain) is the predominant symptom. This classification is supported by recent evidence suggesting that predominant symptoms, but not symptom clusters, identify subgroups with distinct underlying pathophysiological disturbances and responses to treatment. Aerophagia is an unusual complaint characterized by air swallowing that is objectively observed and troublesome repetitive belching. Functional vomiting refers to frequent episodes of recurrent vomiting that is not self-induced nor medication induced, and occurs in the absence of eating disorders, major psychiatric diseases, abnormalities in the gut or central nervous system, or metabolic diseases that can explain the symptom. The current classification requires careful validation but the criteria should be of value in future research.
The age of AIDS: a great time for defensive living
Authors: G. D. Lundberg
Journal: JAMA (1985)

It was the age of overindulgence. It was the age of tolerance for anything in anybody. It was the age of fear of imposing one's own social values on someone else. It was the age of the trivialization of sex. It was the age of anticelibacy. It was the age when early teenage sex was commonplace. It was the age when homosexuality came out of the closet and became almost acceptable to those who once found it intolerable. It was the age of easy, irresponsible oversex, abortion on demand, chlamydia, and genital herpes. And it was the age of AIDS. Not since syphilis among the Spanish, plague among the French, tuberculosis among the Eskimos, and smallpox among the American Indians has there been the threat of such a scourge. Yet, the acquired immunodeficiency syndrome (AIDS) is different from any disease previously seen clinically and epidemiologically. After the torrents of words
Aim of Medical Education, and Its Relation to Research Work by Medical Students.
Authors: W. S. Christopher
Journal: JAMA (1901)

Chicago, Sept. 23, 1901. <h3>To the Editor:</h3> —The editorial in your issue of Sept. 21st, commenting upon my paper on "The Aim of Medical Education, and Its Relation to Research Work by Medical Students," which appeared in the same issue, shows such a lack of understanding of the points of the paper that I beg the privilege of reply. The writer of the editorial has distinctly misunderstood my use of the expression: "Original research has for its object the determining of new truths of a more or less general character." I do not blame him for this, as the language is imperfect, and I felt it at the time of writing. The language would have been better had I omitted the limiting phrase, "of a more or less general character." What I had in mind, however, which gave rise to the phrase was this: Every truth in one of the
Geburtshilfe und Frauenheilkunde, Stuttgart
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
It is all about peri‐implant tissue health
Authors: Frank Schwarz, Ausra Ramanauskaite
Journal: Periodontology 2000 (2022)

Abstract Healthy peri‐implant tissues have become synonymous with implant success and a major challenge in contemporary implant dentistry. Numerous local and systemic factors, as well as iatrogenic and other hitherto underappreciated factors of potential clinical relevance may influence the outcome of implant therapy. In this volume of Periodontology 2000, a group of outstanding experts has elaborated on the latest insights on the prevention and management of major surgical, biological and technical complications, to facilitate the establishment and maintenance of peri‐implant health. This volume focusses on factors affecting early and late implant loss and the potential role of systemic diseases and local conditions. It comprehensively discusses the implementation of guided implant surgery to facilitate the cleansibility of implant‐supported restorations, as well as iatrogenic factors related to bone augmentation/sinus grafting procedures. The challenges associated with soft‐tissue grafting and the prevention of esthetic complications are also reviewed as the paradigm of success in implant dentistry shifts from implant survival towards a greater focus on patient‐reported outcomes. Prosthetic failures remain a significant challenge and are discussed in light of new evidence, as is the relevance of the structural dimensions of the peri‐implant mucosa. The volume closes with detailed and well‐illustrated appraisals of the surgical management of peri‐implantitis, the management and sequelae of dental implant removal, and the latest evidence for the oral health related quality of life in patients treated with dental implants.
<scp>Transfusion‐dependent</scp> anemia secondary to vitamin C deficiency
Authors: Allison M. Angeli, Bryant Megna, Marshall Mazepa, Zalaya K. Ivy, Shahnaz Sultan, Joshua A. Sloan
Journal: American Journal of Hematology (2022)

Transfusion-dependent anemia secondary to vitamin C deficiencyTo the Editor: Scurvy, or the syndrome of vitamin C deficiency, is rare in industrialized nations though is still seen in underserved populations and those with risk factors for severe malnutrition.It presents with fatigue, myalgias, arthralgias, skin and mucosal bleeding, perifollicular hemorrhage, gingivitis, and coiled body hair.2][3][4] We present a case of scurvy manifesting with profound transfusion-dependent anemia.A 57-year-old man presented to the emergency department due to symptomatic anemia (hemoglobin 5.7 g/dl).He noted 2 weeks of dyspnea on exertion, dizziness, arthralgias, myalgias, and easy bruising.Vitals were notable for hypotension at 72/54 mmHg.Physical exam demonstrated bilateral lower extremity edema, tenderness, and ecchymoses.Hemoglobin was 5.1 g/dl and reticulocyte
Old King Coal — molecular mechanisms underlying an ancient treatment for atopic eczema
Authors: W.H. Irwin McLean, Alan D. Irvine
Journal: Journal of Clinical Investigation (2013)

Traditional remedies for common disorders have been known for centuries, but insight into their mechanism of action is often limited. In this issue of the JCI, Joost Schalkwijk’s research group at the Radboud University Nijmegen Medical Centre in The Netherlands advances our understanding of why topical coal tar is an effective treatment for atopic dermatitis (AD), both rationalizing the use of this traditional medicine, and providing the scientific basis for new therapeutic approaches.
AB1356 Observed dosing and refill compliance in bio-naÏve and bio-experienced rheumatoid arthritis patients treated with golimumab
Authors: L. Ellis, S. Haas, S. Bolge, N. Tandon
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Little information on dosing, and refill compliance in golimumab-treated patients with rheumatoid arthritis has been published. <h3>Objectives</h3> This study reports golimumab (GLM) dosing and refill compliance observed in rheumatoid arthritis (RA) patients. <h3>Methods</h3> This retrospective database analysis assessed GLM use in adult RA patients with ≥2 GLM prescriptions between 4/24/2009 and 12/31/2010; ≥1 RA diagnosis during the study period; continuous activity in the Source® LX database (≥6 months pre; ≥6 months post index prescription) and a 28-31 day GLM supply. Refill compliance was defined as refills occurring ± 1 week of the expected 28-31 day (d) interval. The percent of compliant GLM refill intervals and the percent of patients demonstrating refill compliance at the 6th GLM dose were assessed in the overall population and in bio-naïve/bio-experienced subgroups. Descriptive statistics were used to characterize the study population (mean ± SD, median, n and %). <h3>Results</h3> A total of 1,103 RA patients and 6,432 GLM refill intervals were observed. The sample was 82% female; mean age of 53 years with 63% bio-experienced. A 50 mg GLM dose was found in 98% of all fills. The mean ± SD refill interval for the overall population was 35.7±22.0 d with a median of 31 d. Bio-experienced patients had slightly more frequent refill intervals (35.4±21.3 d) as compared to bio-naïve patients (36.3±23.0 d), but the median was 31 d in both subgroups. Refill compliance was observed in 80% of all intervals for the overall population. Refill compliance at the 6th GLM dose was achieved by 84% of patients overall. <h3>Conclusions</h3> In this retrospective analysis of a large national administrative claims database, 98% of GLM doses were 50 mg with approximately once monthly refill intervals. Overall refill compliance was observed in 80% of all GLM refills and in greater than 80% of RA patients at the sixth GLM dose. Median refill interval and refill compliance appeared similar in bio-experienced and bio-naïve subgroups. Further study of these trends using additional data sources are desired to substantiate these preliminary findings. <h3>Disclosure of Interest</h3> L. Ellis Employee of: Janssen Scientific Affairs, LLC, S. Haas Consultant for: Janssen Scientific Affairs, LLC, S. Bolge Employee of: Janssen Scientific Affairs, LLC, N. Tandon Employee of: Janssen Scientific Affairs, LLC