tbuckley/cabot-search huggingface dataset:
Association Between the Sulfur Microbial Diet and Risk of Colorectal Cancer
Authors: Yiqing Wang, Long H. Nguyen, Raaj S. Mehta, Mingyang Song, Curtis Huttenhower, Andrew T. Chan
Journal: JAMA Network Open (2021)

<h3>Importance</h3> Sulfur-metabolizing bacteria that reduce dietary sulfur to hydrogen sulfide have been associated with colorectal cancer (CRC). However, there are limited studies investigating the association between diet and sulfur-metabolizing bacteria in the development of CRC. <h3>Objective</h3> To develop a dietary score that correlates with gut sulfur–metabolizing bacteria and to examine its association with CRC risk. <h3>Design, Setting, and Participants</h3> This prospective cohort study included data from the Health Professionals Follow-up Study (1986-2014), Nurses' Health Study (1984-2016), and Nurses' Health Study II (1991-2017). Participants were US male health professionals and female registered nurses who were free of inflammatory bowel disease and cancer at baseline, with a subsample of participants who provided stool samples from 2012 to 2014. Statistical analysis was conducted from September 1, 2020, to June 1, 2021. <h3>Exposure</h3> A dietary pattern, assessed by a food-frequency questionnaire, that most correlated with 43 sulfur-metabolizing bacteria identified through taxonomic and functional profiling of gut metagenome data. <h3>Main Outcomes and Measures</h3> Incident CRC. <h3>Results</h3> Among 214 797 participants comprising 46 550 men (mean [SD] age at baseline, 54.3 [9.7] years) and 168 247 women (mean [SD] age at baseline, 43.0 [9.2] years), 3217 incident cases of CRC (1.5%) were documented during 5 278 048 person-years of follow-up. The sulfur microbial diet, developed in a subsample of 307 men (mean [SD] age, 70.5 [4.3] years) and 212 women (mean [SD] age, 61.0 [3.8] years), was characterized by high intakes of low-calorie beverages, french fries, red meats, and processed meats and low intakes of fruits, yellow vegetables, whole grains, legumes, leafy vegetables, and cruciferous vegetables. After adjustment for other risk factors, greater adherence to the sulfur microbial diet was associated with an increased risk of CRC, with a hazard ratio (HR) of 1.27 (95% CI, 1.12-1.44) comparing the highest vs the lowest quintile of the diet score (linear trend of diet score quintiles;<i>P</i> &lt; .001 for trend). When assessed by anatomical subsites, greater adherence to the sulfur microbial diet was positively associated with distal CRC (HR, 1.25; 95% CI, 1.05-1.50;<i>P</i> = .02 for trend) but not proximal colon cancer (HR, 1.13; 95% CI, 0.93-1.39;<i>P</i> = .19 for trend). <h3>Conclusions and Relevance</h3> Adherence to the sulfur microbial diet was associated with an increased risk of CRC, suggesting a potential mediating role of sulfur-metabolizing bacteria in the associaton between diet and CRC. Further research is needed to confirm these findings and to determine the underlying mechanisms.
One‐Step Synthesis of Multifunctional Chitosan Hydrogel for Full‐Thickness Wound Closure and Healing
Authors: Shen Guo, Minghao Yao, Dan Zhang, Yuanmeng He, Rong Chang, Yikun Ren, Fangxia Guan
Journal: Advanced Healthcare Materials (2021)

Multifunctional hydrogel as a sealant or wound dressing with high adhesiveness and excellent antibacterial activity is highly desirable in clinical applications. In this contribution, one-step synthetic hydrogel based on quaternized chitosan (QCS), tannic acid (TA), and ferric iron (Fe(III)) is developed for skin incision closure and Staphylococcus aureus (S. aureus)-infected wound healing. In this hydrogel system, the ionic bonds and hydrogen bonds between QCS and TA form the main backbone of hydrogel, the metal coordination bonds between TA and Fe(III) (catechol-Fe) endow hydrogel with excellent adhesiveness and (near-infrared light) NIR-responsive photothermal property, and these multiple dynamic physical crosslinks enable QCS/TA/Fe hydrogel with flexible self-healing ability and injectability. Moreover, QCS/TA/Fe hydrogel possesses superior antioxidant, anti-inflammatory, hemostasis, and biocompatibility. Also, it is safe for vital organs. The data from the mouse skin incision model and infected full-thickness skin wound model presented the high wound closure effectiveness and acceleration of the wound healing process by this multifunctional hydrogel, highlighting its great potential in wound management.
Abstract PO-060: N-terminal RHAMM cooperates with dysfunctional p53 to accelerate the progression of pancreatic cancer
Authors: Anthony Lin, Jennifer Feng, Xiang Chen, Dunrui Wang, Megan Wong, George Zhang, Joseph Na, Tiantian Zhang, Zhengming Chen, Yao-Tseng Chen, Yi-Chieh Nancy Du
Journal: Cancer Research (2021)

Abstract Pancreatic cancer has the lowest survival rate in all types of cancer. Pancreatic cancer patients are often diagnosed at advanced stages. A better therapeutic development for this devastating disease is urgently needed. Receptor for hyaluronan-mediated motility (RHAMM), not expressed in adult normal pancreas, has been suggested as a prognostic factor and a potential therapeutic target for pancreatic ductal adenocarcinoma (PDAC) and pancreatic neuroendocrine tumor (PNET). In this study, we initially sought to determine whether genetic deletion of RHAMM would slow down pancreatic cancer progression using Rhamm−/− mice. However, we found that Rhamm−/− mice expressed a N-terminal RHAMM protein. While N-terminal RHAMM did not enable malignant progression of pancreatic intraepithelial neoplasia in p48-Cre; LSL-KRASG12D mice, it accelerated the formation of invasive PDAC and shortened the survival of p48-Cre; LSL-KRASG12D mice with heterozygous p53 knockout. KrasG12D PDAC mice with homozygous p53 knockout mice died around 10 weeks, and the effect of N-terminal RHAMM was not apparent in these mice with short life span. In addition, N-terminal RHAMM shortened the survival of PNET-bearing RIP-Tag mice, which had inactivated p53. In our analysis of TCGA dataset, pancreatic cancer patients with mutant TP53 or loss of one copy of TP53 had higher RHAMM expression, which, combined, predicted worse outcomes. Taken together, by collaborating with dysfunctional p53, N-terminal RHAMM that lacks the centrosome targeting domain and degrons for interaction with the Anaphase-Promoting Complex (APC) accelerated pancreatic cancer progression. Citation Format: Anthony Lin, Jennifer Feng, Xiang Chen, Dunrui Wang, Megan Wong, George Zhang, Joseph Na, Tiantian Zhang, Zhengming Chen, Yao-Tseng Chen, Yi-Chieh Nancy Du. N-terminal RHAMM cooperates with dysfunctional p53 to accelerate the progression of pancreatic cancer [abstract]. In: Proceedings of the AACR Virtual Special Conference on Pancreatic Cancer; 2021 Sep 29-30. Philadelphia (PA): AACR; Cancer Res 2021;81(22 Suppl):Abstract nr PO-060.
Updated Phase 1 Results of C-CAR088, an Anti-BCMA CAR T-Cell Therapy in Relapsed or Refractory Multiple Myeloma
Authors: Xiaoyan Qu, Gang An, Weiwei Sui, Tingyu Wang, Xian Zhang, Junfang Yang, Yan Zhang, Lu Zhang, Judy Zhu, Jiaqi Huang, Jing Li, Shirley Zheng, Kevin Zhu, Liping Lan, Shiyi Chen, Michael Humphries, Yihong Yao, Daobin Zhou, Peihua LU, Lugui Qiu, Jianyong Li
Journal: Blood (2021)
Mapping Human Pluripotent Stem Cell-Derived Erythroid Differentiation by Single-Cell Transcriptome Analysis
Authors: Zijuan Xin, Wei Zhang, Shangjin Gong, Junwei Zhu, Yanming Li, Zhaojun Zhang, Xiangdong Fang
Journal: Genomics Proteomics & Bioinformatics (2021)

There is an imbalance between the supply and demand of functional red blood cells (RBCs) in clinical applications. This imbalance can be addressed by regenerating RBCs using several in vitro methods. Induced pluripotent stem cells (iPSCs) can handle the low supply of cord blood and the ethical issues in embryonic stem cell research, and provide a promising strategy to eliminate immune rejection. However, no complete single-cell level differentiation pathway exists for the iPSC-derived erythroid differentiation system. In this study, we used iPSC line BC1 to establish a RBC regeneration system. The 10X Genomics single-cell transcriptome platform was used to map the cell lineage and differentiation trajectory on day 14 of the regeneration system. We observed that iPSC differentiation was not synchronized during embryoid body (EB) culture. The cells (on day 14) mainly consisted of mesodermal and various blood cells, similar to the yolk sac hematopoiesis. We identified six cell classifications and characterized the regulatory transcription factor (TF) networks and cell-cell contacts underlying the system. iPSCs undergo two transformations during the differentiation trajectory, accompanied by the dynamic expression of cell adhesion molecules and estrogen-responsive genes. We identified erythroid cells at different stages, such as burst-forming unit erythroid (BFU-E) and orthochromatic erythroblast (ortho-E) cells, and found that the regulation of TFs (e.g., TFDP1 and FOXO3) is erythroid-stage specific. Immune erythroid cells were identified in our system. This study provides systematic theoretical guidance for optimizing the iPSC-derived erythroid differentiation system, and this system is a useful model for simulating in vivo hematopoietic development and differentiation.
How Effective Are the Immunosuppressive Therapies Rituximab and Mycophenolate Mofetil in Immune Thrombocytopenia? Real World Evidence from the UK ITP Registry
Authors: Vickie McDonald, Gerorge Loughlin, Andrew Laws, Duncan Stacey, Jeffrey Spears, Atiqa Miah, Haroon Miah, Quentin Hill, Nichola Cooper, Michael Makris, Charlotte Bradbury, Adrian C. Newland
Journal: Blood (2021)
Resolving Interference of Direct Oral Anticoagulants (DOACs) on Routine Coagulation, Thrombophilia, and Lupus Anticoagulant Testing Using Activated Carbon
Authors: Pierre Toulon, Mathilde Vannini, Anny Appert-Flory, Florence Fischer, Didier Jambou, Bouadjar Dahmani
Journal: Blood (2021)
<i>High Plasma Apolipoprotein(a) Concentration and Low Plasmin Tpa Enzymatic Activity in Hospitalized Patients with COVID-19</i>
Authors: Ziyu Zhang, Wen Dai, Wen Zhu, Maya Rodriguez, Mary Rau, Hayley Lund, Lisa Baumann Kreuziger, Renren Wen, Roy L. Silverstein, Ze Zheng
Journal: Blood (2021)
Large-Scale Mass Cytometry Reveals Significant Activation of Innate and Adaptive Immunity in Bone Marrow Tumor Microenvironment of Iberdomide-Treated Myeloma Patients
Authors: Oliver Van Oekelen, Michael Amatangelo, Manman Guo, Bhaskar Upadhyaya, Geoffrey Kelly, Manishkumar Patel, Seunghee Kim-Schulze, Alessandro Lagana, Sarah Gooding, Sundar Jagannath, William E. Pierceall, Udo Oppermann, Samir Parekh, Anjan Thakurta
Journal: Blood (2021)
Outcomes for Myelofibrosis Patients Following Myeloablative Allogeneic Stem Cell Transplantation Using the Orca-T Graft from HLA-Matched Related and Unrelated Donors
Authors: Arpita Gandhi, Anna Moroz, Lori Muffly, Parveen Shiraz, Levanto Schachter, Nathaniel B Fernhoff, J Scott McClellan, Robert S. Negrin, Jason Gotlib, Everett H Meyer
Journal: Blood (2021)
Improving surgical training: Establishing a surgical anatomy programme in Scotland
Authors: Ross A. Jones, Jeremy W. Mortimer, Christopher S.G. Thompson, Saskia Clark-Stewart, Gemma Hogg, Shivank Keni, Victoria McCulloch, Abduelmenem Alashkham, Sameer Dhumale, Stephen J. Maclean, Mark Vella, Gordon S. Findlater, David W. Sinclair, Satheesh Yalamarthi, Thomas H. Gillingwater
Journal: International Journal of Surgery (2021)

It is well recognized that a sound foundation in surgical anatomy is a cornerstone of safe surgical practice, yet many trainees struggle with the upskilling in anatomy that is required to support their day-to-day practice. In the context of the UK-wide Improving Surgical Training pilot, we set out to establish a surgical anatomy programme for core surgical trainees in the Scotland Deanery. The aim was to enable all trainees to review the surgical anatomy of the whole body to MRCS level at least once during core surgical training.Teaching was delivered in Edinburgh, with trainees commuting from all parts of the Scotland Deanery. Individual teaching days focused on the surgical anatomy of the head and neck, trunk and limbs, using a combination of lectures (principles and cases) and interactive demonstrations on prosected specimens. Faculty comprised a balance of surgical demonstrators and senior academic staff, including MRCS examiners.In total, 16 individual teaching sessions were attended by over 300 trainees across the first 2 years of the programme. Evaluation form response rate was nearly 80%. The programme was highly rated by trainees in relation to the method of delivery, level of teaching and surgical focus.Surgical anatomy remains an integral part of surgical training. Our experience in developing a deanery-wide surgical anatomy programme highlights the crucial links between medical school, training deanery and surgical college. This collaborative approach can be extended to higher surgical training and continuing professional development, and the methods can be adapted to meet the needs of trainees in different parts of the globe.
Sudden or Cardiac Deaths on Ibrutinib-Based Therapy Were Associated with a Prior History of Hypertension or Cardiac Disease and the Use of ACE-Inhibitors at Study Entry: Analysis from the Phase III NCRI FLAIR Trial
Authors: Talha Munir, Alexandra Pitchford, Adrian Bloor, Angus Broom, Moya Young, Ben Kennedy, Renata Walewska, Michelle Furtado, Gavin Preston, Jeffrey R. Neilson, Nicholas Pemberton, Gamal Sidra, Nicholas Morley, Kate Cwynarski, Anna Schuh, Francesco Forconi, Simona Gatto, Shankara Paneesha, Christopher P. Fox, Dena Howard, Anna Hockaday, David Cairns, Sharon Jackson, Natasha Greatorex, Piers EM Patten, David Allsup, Peter Hillmen
Journal: Blood (2021)
Clonal Evolution Pattern and Prognostic Significance of Clonal Architecture in <i>KMT2A</i>-Rearranged Acute Myeloid Leukemia
Authors: Hidemasa Matsuo, Kenichi Yoshida, Yasuhito Nannya, Yuri Ito, Shoji Saito, Yuhki Koga, Hiroshi Moritake, Kiminori Terui, Koji Kawaguchi, Yasuhiro Okamoto, Hideki Nakayama, Kanno Miyako, Moeko Hino, Yusuke Akane, Akiko Inoue, Akira Shimada, Hiroaki Goto, Hiroo Ueno, Junko Takita, Genki Yamato, Norio Shiba, Yasuhide Hayashi, Yuichi Shiraishi, Satoru Miyano, Nobutaka Kiyokawa, Daisuke Tomizawa, Takashi Taga, Akio Tawa, Seishi Ogawa, Souichi Adachi
Journal: Blood (2021)
A Phase II Study of the Efficacy and Tolerance of Azacytidine (AZA) in Steroid Dependent/Refractory Systemic Autoimmune and Inflammatory Disorders (SAID) Associated with MDS or CMML (GFM- AZA-SAID -trial)
Authors: Arsène Mékinian, Lin-Pierre Zhao, Kristell Desseaux, Rose Rose, Laurent Pascal, Pierre Peterlin, Thibault Comont, Alexandre Maria, Louis Terriou, Maud d'Aveni, Marie-Pierre Gourin, Norbert Vey, Odile bayne Rouzy, Sophie Dimicoli Salazar, Anne Banos, Stefan Wickenhauser, Benoit De Renzis, Eric Durot, Shanti Ame, Laurent Voillat, Fatiha Chermat, Anne Vekhoff, Karine Lemaire, Vincent Jachiet, Sylvie Chevret, Lionel Ades, Olivier Fain, Pierre Fenaux
Journal: Blood (2021)
European Leukemianet (ELN) Response Predicts Disease Progression but Not Thrombosis or Death in Polycythemia Vera (PV): An Analysis of a Multicenter Database
Authors: Douglas Tremblay, Andrew Srisuwananukorn, Lukas Ronner, Nikolai Podoltsev, Jason Gotlib, Mark L. Heaney, Andrew T. Kuykendall, Casey L. O'Connell, Jamile M. Shammo, Angela Fleischman, Ruben A. Mesa, Abdulraheem Yacoub, Ronald Hoffman, Erin Moshier, Nicole Zubizarreta, John Mascarenhas
Journal: Blood (2021)
Abstract 8999: Impact of Coronavirus 2019 on Pediatric and Adult Heart Transplantation Waitlist Activity and Mortality in the United States
Authors: Awais Ashfaq, Geoffrey Gray, Jennifer Carapellucci, Ernest K Amankwah, Luis M Ahumada, Michael PUCHALSKI, Andrew Smith, Mohamed Rehman, James A Quintessenza, Alfred Asante-Korang
Journal: Circulation (2021)

Introduction: Transplant centers saw a reduction in solid organ transplantation since the beginning of the coronavirus 2019 (COVID-19) pandemic in the United States. Limited data exists on the impact of COVID-19 on pediatric heart transplant volume and variation in transplant practices. We hypothesized that pediatric heart transplant activity decreased during COVID-19 with associated increased waitlist mortality. Methods: The United Network for Organ Sharing (UNOS) database was used to identify waitlisted patients from 2017-2020. Regional and Statewide data was obtained from US Census Bureau. CovidActNow project was used for Covid-19 mortality rates. Results: Among pediatric patients, average time on the waiting list decreased by 28 days. Even though the average number of pediatric transplants (n=39) did not change during 2020, there was a temporal decline in the first quarter followed by an increase. Overall pediatric waitlist mortality decreased from 5.31 to 4.73, however female mortality increased by 2%. Regional differences in pediatric mortality included: Northeast, decreased by 7.5%; Midwest, decreased by 9%; West, increased by 3.5%; and South, increased by 13%. North Dakota (0.55), Oklahoma (0.21) and Hawaii (0.33) showed higher mortality per 100,000 than other states. In adults, average time on waiting list increased by 40 days and there was an increase in the number of transplants from 242.06 to 266.09. Adult waitlist mortality had a larger decrease from 18.44 to 15.70 with increase in female mortality of 7%. Regional differences in adult mortality included: Northeast, decreased by 3%; Midwest, increased by 5.5%; West, increased by 4.5% and South, decreased by 5%. Iowa (0.37), Wyoming (0.22), Arkansas (0.18) and Vermont (0.19) had higher mortality per 100,000 than other states . Conclusions: Pediatric heart transplant volume declined in early 2020 followed by an increase, while transplant volume in adults increased. Although, overall waitlist mortality for pediatrics decreased, female waitlist mortality increased. Regional differences in waitlist mortality were also observed. Future studies are needed to understand this initial correlation and to determine the impact of COVID-9 on heart transplant recipients.
Quality of Life and Life Satisfaction in AML Long-Term Survivors: Primary Results of the AMLCG-Survivorship Study
Authors: Eva Telzerow, Dennis Görlich, Maja Rothenberg-Thurley, Maria Cristina Sauerland, Anna Sophia Moret, Friederike H. A. Mumm, Susanne Amler, Wolfgang E. Berdel, Bernhard J. Wörmann, Utz Krug, Jan Braess, Pia Heußner, Wolfgang Hiddemann, Karsten Spiekermann, Klaus H. Metzeler
Journal: Blood (2021)
Complete Versus Incomplete Hematologic Recovery after CAR T Cell Therapy: Implications for Relapse Free Survival and Overall Survival in Pediatric and Young Adult Patients with Relapsed/Refractory B-ALL
Authors: Benjamin J Lerman, Yimei Li, Hongyan Liu, Regina M. Myers, Kaitlin Devine, Colleen Callahan, Diane Baniewicz, Stephan Kadauke, Amanda M. DiNofia, Susan R. Rheingold, Lisa Wray, Richard Aplenc, Stephan A. Grupp, Shannon L. Maude, Allison Barz Leahy
Journal: Blood (2021)
Abstract 9214: β-arrestin-biased Receptor CXCR7 in Cardiomyocytes Acts on Cell Survival and Inhibits Post-Infarction Remodeling
Authors: Masato Ishizuka, Mutsuo Harada, Seitaro Nomura, Toshiyuki Ko, Satoshi Bujo, Jiaxi Guo, Bowen Zhai, Risa Kishikawa, Haruhiro TOKO, Issei Komuro
Journal: Circulation (2021)

Introduction: Seven transmembrane receptors (7TMRs) play various important roles in the heart in which β-arrestin-biased agonism has been recently reported to be cardioprotective. Chemokine receptor CXCR7 is a 7TMR expressed in the heart and binds not to G protein but only to β-arrestin, serving as a β-arrestin-biased receptor. The expression levels of CXCL12, the ligand of CXCR7, are increased in myocardial infarction (MI) but the role of CXCL12/CXCR7 in MI remains elusive. Hypothesis: CXCR7 protects the heart from myocardial infarction as a β-arrestin-biased receptor. Methods and Results: First, we performed bulk RNA sequencing (RNAseq) in murine hearts and found Cxcr7 to be the most abundantly expressed 7TMR. We next used single-cell RNAseq and demonstrated that Cxcr7 was strongly expressed in cardiomyocytes and fibroblasts but not in the other type of cells. Second, we generated cardiomyocyte-specific Cxcr7 knockout (cKO) mice and induced MI by left anterior descending artery ligation. Cxcr7 cKO mice showed significantly exacerbated cardiac dilation and dysfunction at 4 weeks after MI compared to controls. In contrast, fibroblast-specific knockout mice showed no such difference. Third, we revealed that CXCL12 recruited β-arrestin to CXCR7 in CXCR7 expressing cells. We stimulated cultured neonatal rat ventricular myocytes with CXCL12 and induced cell death by oxygen glucose deprivation. ERK was activated and cell death was suppressed by CXCR7 stimulation. In the border zone of mouse infarcted hearts, Cxcr7 expression was increased and ERK was activated, which was attenuated in Cxcr7 cKO hearts. Finally, CXCR7 expression was also increased in human failing hearts, suggesting CXCR7 is also associated with human heart failure. Conclusion: CXCR7 is predominantly expressed in cardiomyocytes, acts on cell survival through ERK activation, and inhibits post-infarction remodeling. CXCR7 may be a new therapeutic target for MI.
Safety and Efficacy of Off-the-Shelf CD30.CAR-Modified Epstein-Barr Virus-Specific T Cells in Patients with CD30-Positive Lymphoma
Authors: David H. Quach, Carlos A. Ramos, Premal D. Lulla, Sandhya Sharma, Haran R. Ganesh, Yezan F. Hadidi, Sachin G. Thakkar, Luis Becerra-Dominguez, Birju Mehta, Silvana Perconti, Eric Anderson, Emily M. Hsieh, Olga Dakhova, Huimin Zhang, Bambi J. Grilley, Malcolm K. Brenner, Helen E. Heslop, Rayne H. Rouce, Natalia Lapteva, Cliona M. Rooney
Journal: Blood (2021)
Role of Mir-192-5p during Response to Azacitidine and Lenalidomide Therapy in Myelodysplastic Syndromes
Authors: Matilde Y Follo, Alessia De Stefano, Sara Mongiorgi, Valentina Indio, Annalisa Astolfi, Stefano Ratti, Andrea Pellagatti, Miriam Fogli, Andrea Pession, Michele Cavo, Lucia Manzoli, Lucio Cocco, Jacqueline Boultwood, Sarah Parisi, Stefania Paolini, Carlo Finelli
Journal: Blood (2021)
Mesenchymal Stromal Cells Plus Anti-CD25 Antibody and Calcineurin Inhibitors for Steroid-Resistant Acute Graft-Versus-Host Disease: A Multicenter, Randomized, Phase 3 Trial
Authors: Ke Zhao, Ren Lin, Zhiping Fan, Xiaoyong Chen, Yu Wang, Fen Huang, Na Xu, Xi Zhang, Xin Zhang, Li Xuan, Shunqing Wang, Dongjun Lin, Lan Deng, Danian Nie, Jianyu Weng, Yonghua Li, Xiaohui Zhang, Yuhua Li, Andy Peng Xiang, Qifa Liu
Journal: Blood (2021)
Frequency, Pattern, and Associations of Renal Iron Accumulation in Sickle Beta-Thalassemia
Authors: Alessia Pepe, Luigi Barbuto, Laura Pistoia, Vincenzo Positano, Francesco Massei, Letizia Tedesco, Valentina Carrai, Angelantonio Vitucci, Aurelio Maggio, Giuseppe Peritore, Priscilla Fina, Antonella Meloni
Journal: Blood (2021)
Manufacturing Bispecific LV20.19 CAR T-Cells with IL-7 &amp; IL-15 for a Shorter Duration Improves CAR T-Cell Immunophenotype While Maintaining Target Cell Dose
Authors: Joanna C. Zurko, Katherine Chaney, Huiqing Xu, Dina Schneider, Parameswaran Hari, Bryon Johnson, Nirav N. Shah
Journal: Blood (2021)
Biomaterial-mediated modulation of oral microbiota synergizes with PD-1 blockade in mice with oral squamous cell carcinoma
Authors: Di-Wei Zheng, Wei-Wei Deng, Wen-Fang Song, Cong-Cong Wu, Jie Liu, Sheng Hong, Ze-Nan Zhuang, Han Cheng, Zhi-Jun Sun, Xian-Zheng Zhang
Journal: Nature Biomedical Engineering (2021)
A simple clinical score to promote and enhance ferroportin disease screening
Authors: Amandine Landemaine, Houda Hamdi-Roze, Séverine Cunat, Véronique Loustaud-Ratti, Xavier Causse, Si Nafa Si Ahmed, Bernard Drénou, Christophe Bureau, Gilles Pelletier, Caroline De Kerguenec, Nathalie Ganne-Carrie, Stéphane Durupt, Fabrice Laine, Olivier Loréal, Martine Ropert, Lenaick Detivaud, Jeff Morcet, Patricia Aguilar-Martinez, Yves M. Deugnier, Edouard Bardou-Jacquet
Journal: Journal of Hepatology (2021)