tbuckley/cabot-search huggingface dataset:
Clinical Audiometry
Authors: Lyle M. Sellers
Journal: JAMA (1961)

Out of the literal spate of works on audiology now issuing from publishing houses, this book stands preeminent as a basic hand tool of the American practicing otologist. This work is elemental in its simplicity and profound in the scholarship entered into its preparation. It is the result of the collaboration of a justly, world renowned otologist and a physician-audiologist. Nothing is presented that is of only theoretical interest. The basic anatomy and physiology of the conductive and perceptive hearing mechanisms is presented clearly and concisely. The various clinical tests of these mechanisms and their raison d' etre are presented by definitive explanation or by explanatory definition so that the tyro may digest them, and the advanced otologist may feast and savor of their finer applications to the clinical problems of every day as well as every other day practice. Here is an ideal of otologic-audiologic practice that reaches full
Symptom Burden of Busulfan + Melphalan Versus Melphalan Alone for Multiple Myeloma
Authors: Loretta A. Williams, Muzaffar H. Qazilbash, Qiuling Shi, Nina Shah, Qaiser Bashir, Richard E. Champlin, Uday R. Popat, Partow Kebriaei, Simrit Parmar, Achala R. Limaye, Charles S. Cleeland
Journal: Blood (2014)
Current Comment
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
COPD: cells and genes
Authors: Elastase Activity, R Carter, R Mumford, K Treonze, R Stockley, N Chaudhuri, L Parker, I Sabroe, K Donaldson, A Soltani, S Sohal, D Reid, S Muller, R Weston, Walters Wood-Baker, Jes Park, P Upton, P De Souza, R Davies, N Morrell, Mjd Griffiths
Journal: Thorax (2009)

experience and evaluate the clinical efficacy and safety of removable SEMS.Methods We conducted a retrospective study between January 2005 and July 2009.Data analysis was carried out using SPSS.Results 36 stents were inserted in a total of 33 patients (20 males and 13 females).The mean age was 59.7¡14.4 years (range 22-81).32 stents (84.2%) were deployed for malignant conditions and 4 (10.5%) for benign diseases.81.8% of patients had malignant airway obstruction and 6.1% had tracheo-oesophageal fistulae.Obstruction was located to the trachea in 44.4% of cases.88.9% of patients reported improvement in symptoms in the first 24 h.62.9% of patients were in severe respiratory distress prior to SEMS insertion, with immediate improvement thereafter.Complications were reported in 14 stents, with 2 presenting within 24 h.We recorded 1 case of stent fracture, 6 cases of migration, 5 cases of mucus plugging, 1 minor bronchial tear associated with stent placement, and 1 case of stent-associated respiratory tract infection.12 stents were easily removed, with no associated complications.17 deaths were reported, none related to stent insertion and all were in patients with advanced malignant disease.Survival for these patients ranged from 7 to 430 days poststent insertion.Conclusions SEMS provide an effective, safe and feasible therapeutic modality in patients with benign and malignant airway stenoses.Although associated with significant complications, they have the advantage of providing immediate relief from breathlessness and imminent asphyxia.In patients with malignancy, SEMS enable definitive oncological treatment to be given electively, and in greater safety, and are easily removed after completion of treatment.
Racial Inequality in Prescription Opioid Receipt — Role of Individual Health Systems
Authors: Nancy E. Morden, Deanna Chyn, Andrew Wood, Ellen Meara
Journal: New England Journal of Medicine (2021)

Historically, the receipt of prescription opioids has differed among racial groups in the United States. Research has not sufficiently explored the contribution of individual health systems to these differences by examining within-system prescription opioid receipt according to race.We used 2016 and 2017 Medicare claims data from a random 40% national sample of fee-for-service, Black and White beneficiaries 18 to 64 years of age who were attributed to health systems. We identified 310 racially diverse systems (defined as systems with ≥200 person-years each for Black and White patients). To test representativeness, we compared patient characteristics and opioid receipt among the patients in these 310 systems with those in the national sample. Within the 310 systems, regression models were used to explore the difference between Black and White patients in the following annual opioid measures: any prescription filled, short-term receipt of opioids, long-term receipt of opioids (one or more filled opioid prescriptions in all four calendar quarters of a year), and the opioid dose in morphine milligram equivalents (MME); models controlled for patient characteristics, state, and system.The national sample included 2,197,153 person-years, and the sample served by 310 racially diverse systems included 896,807 person-years (representing 47.4% of all patients and 56.1% of Black patients in the national sample). The national sample and 310-systems sample differed meaningfully only in the percent of person-years contributed by Black patients (21.3% vs. 25.9%). In the 310-systems sample, the crude annual prevalence of any opioid receipt differed slightly between Black and White patients (50.2% vs. 52.2%), whereas the mean annual dose was 36% lower among Black patients than among White patients (5190 MME vs. 8082 MME). Within systems, the adjusted race differences in measures paralleled the population trends: the annual prevalence of opioid receipt differed little, but the mean annual dose was higher among White patients than among Black patients in 91% of the systems, and at least 15% higher in 75% of the systems.Within individual health systems, Black and White patients received markedly different opioid doses. These system-specific findings could facilitate exploration of the causes and consequences of these differences. (Funded by the National Institute on Aging and the Agency for Healthcare Research and Quality.).
Table of Contents
Journal: Acta Pharmaceutica Sinica B (2015)

Hydrogen sulfide (H 2 S) is recognized as one of three gasotransmitters together with nitric oxide (NO) and carbon monoxide (CO).As a signaling molecule, H 2 S plays an important role in physiology and shows great potential in pharmaceutical applications.Along this line, there is a need for the development of H 2 S prodrugs for various reasons.In this review, we summarize different H 2 S prodrugs, their chemical properties, and some of their potential therapeutic applications.
LETTER FROM NEW YORK.
Authors: None P. B. P.
Journal: JAMA (1889)

(FROM OUR OWN CORRESPONDENT.) Fifth Annual Meeting of the Fifth District Branch of the New York State Medical Association — The President, Prof. Wm. T. Lusk, delivers an admirable Address, in which he treats principally on the subject of Rupture of the Uterus and its Prevention and Treatment—Dr. T. M. Manley, of New York, on the Genesis of Tumors—Dr. F. E. Martindale, of Staten Island, reports a Case of Calcification of the Cardiac Left Ventricular Wall —Dr. T. H. Allen, of New York, on Traumatic Pelvic Cellulitis—Dr. J. G. Truax, of New York, on The Treatment of Acute Lobar Pneumonia— Discussion thereon by Drs. Alfred L. Carroll, E. R. Squibb, S. J. Murray and C. S. Wood, The fifth annual meeting of the Fifth District Branch of the New York State Medical Association, recently held in Brooklyn, was characterized by much good scientific work. In his opening address the
Cost-effectiveness of abciximab and stenting in acute myocardial infarction: Results from the CADILLAC trial David J. Cohen, Cindy Grines, David Cox, Thomas Stuckey, John Carroll, John Griffin, Roberta S. Cosgrove, Louise Githiora, Ronna H. Berezin, James Tcheng, Gregg Stone, CADILLAC Investigators. Beth Israel Deaconess Medical Center, Boston, MA, Cardiovascular Data Analysis Center, Boston, MA
Journal: Journal of the American College of Cardiology (2001)
Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 4: Congenital Heart Disease
Authors: George F. Van Hare, Michael J. Ackerman, Juli-anne K. Evangelista, Richard J. Kovacs, Robert J. Myerburg, Keri M. Shafer, Carole A. Warnes, Reginald L. Washington
Journal: Journal of the American College of Cardiology (2015)
DEATH IS NOT UNANNOUNCED
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Scenes From a Mammogram
Authors: Lisa Michelle Sieczkowski
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Commentary
Authors: Marcin Polkowski
Journal: Endoscopy (2020)

Clinically significant hemorrhage occurs in about 2 % of patients undergoing endoscopic sphincterotomy and is severe in a quarter of cases (i. e., necessitates transfusion of ≥ 5 units of blood, surgery, or angiography). Endoscopic therapies (epinephrine injection, thermal methods, clipping, or tamponade with a covered self-expanding metal stent [SEMS]) are effective in all but rare cases, in which angiographic embolization or surgery may be required. Endoscopic ultrasound (EUS)-guided deployment of an embolization coil as a means to stop bleeding, as in the presented case, is an interesting, outside-the-box approach. The feeding vessel, although small (around 1 mm) was well-visualized on color flow Doppler, it was not obscured by the SEMS, and was favorably located for targeting with an EUS needle. The coil was most likely deployed around the vessel rather than in its lumen; however, this was effective in achieving hemostasis.
Vitamin C and E retard the progression of transplant associated coronary arteriosclerosis-impact of baseline endothelial function Dominik Behrendt, Marco Wainstein, Peter Ganz, Scott Kinlay, James C. Fang. Brigham and Women's Hospital, Boston, MA, Linus Pauling Institute, Corvallis, OR
Journal: Journal of the American College of Cardiology (2001)
THE INFLUENCE OF DEFECTIVE NASAL BREATHING ON GROWTH AND DEVELOPMENT.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New England Journal of Medicine, Boston
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Topical therapy with negative allosteric modulators of the calcium-sensing receptor (calcilytics) for the management of asthma: the beginning of a new era?
Authors: Daniela Riccardi, Jeremy P.T. Ward, Polina L. Yarova, Luke J. Janssen, Tak Hong Lee, Sun Ying, Chris J. Corrigan
Journal: European Respiratory Journal (2022)

In this review article we present the evidence to date supporting the role of the calcium-sensing receptor (CaSR) as a key, pluripotential molecular trigger for asthma and speculate on the likely benefits of topical therapy of asthma with negative allosteric modulators of the CaSR: calcilytics.
408-4 B-type natriuretic peptide levels predict postoperative atrial fibrillation in patients undergoing cardiac surgery
Authors: Oussama M Wazni, David Martin, Nassir Marrouche, Ahmed Abdel Latif, Walid Saliba, Robert Schweikert, A Marc Gillinov, Gary Francis, James Young, Andrea Natale
Journal: Journal of the American College of Cardiology (2004)
Baby Doctor
Authors: Nell Pape Waring
Journal: JAMA (1993)

"Benjamin, I have to tell you something. Boys can be doctors, too, if they want to. If they go to school and learn how, boys can be very good doctors, really." Perri Klass, in the autobiographical account of her pediatric training at Boston Children's Hospital, is about to tell her 4-year-old that his pediatrician is a 'Boys can be doctors, too, if they want to.' "I thought about the doctors my son knows—me, my close friends, mostly female. I picked my words carefully; it was clearly one of those critical moments when all of a mother's wisdom and tact is required." I read that on p 284 and I was already crazy about Perri Klass and her commitment to "wisdom and tact," not only in dealing with Benjamin but also with her peers and supervisors and, most of all, with the children and parents that she encounters in the three
Genomics of Chernobyl Cancers Revealed
Journal: Cancer Discovery (2021)

Abstract The 1986 Chernobyl nuclear power plant disaster in Ukraine exposed millions of people in the region to ionizing radiation, leading to an increased rate of papillary thyroid cancer. Researchers have taken an in-depth look at the molecular profile of these cancers—revealing, among other things, the presence of DNA double-strand breaks that correlate with greater and earlier exposure to radiation.
TREATMENT OF IMPETIGO WITH FRANKLINIZATION.
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis
Authors: Bruce E. Sands, William J. Sandborn, Remo Panaccione, Christopher D. O’Brien, Hongyan Zhang, Jewel Johanns, Omoniyi J. Adedokun, Katherine Li, Laurent Peyrin-Biroulet, Gert Van Assche, Silvio Danese, Stephan Targan, Maria T. Abreu, Tadakazu Hisamatsu, Philippe Szapary, Colleen Marano
Journal: New England Journal of Medicine (2019)

The efficacy of ustekinumab, an antagonist of the p40 subunit of interleukin-12 and interleukin-23, as induction and maintenance therapy in patients with ulcerative colitis is unknown.We evaluated ustekinumab as 8-week induction therapy and 44-week maintenance therapy in patients with moderate-to-severe ulcerative colitis. A total of 961 patients were randomly assigned to receive an intravenous induction dose of ustekinumab (either 130 mg [320 patients] or a weight-range-based dose that approximated 6 mg per kilogram of body weight [322]) or placebo (319). Patients who had a response to induction therapy 8 weeks after administration of intravenous ustekinumab were randomly assigned again to receive subcutaneous maintenance injections of 90 mg of ustekinumab (either every 12 weeks [172 patients] or every 8 weeks [176]) or placebo (175). The primary end point in the induction trial (week 8) and the maintenance trial (week 44) was clinical remission (defined as a total score of ≤2 on the Mayo scale [range, 0 to 12, with higher scores indicating more severe disease] and no subscore >1 [range, 0 to 3] on any of the four Mayo scale components).The percentage of patients who had clinical remission at week 8 among patients who received intravenous ustekinumab at a dose of 130 mg (15.6%) or 6 mg per kilogram (15.5%) was significantly higher than that among patients who received placebo (5.3%) (P<0.001 for both comparisons). Among patients who had a response to induction therapy with ustekinumab and underwent a second randomization, the percentage of patients who had clinical remission at week 44 was significantly higher among patients assigned to 90 mg of subcutaneous ustekinumab every 12 weeks (38.4%) or every 8 weeks (43.8%) than among those assigned to placebo (24.0%) (P = 0.002 and P<0.001, respectively). The incidence of serious adverse events with ustekinumab was similar to that with placebo. Through 52 weeks of exposure, there were two deaths (one each from acute respiratory distress syndrome and hemorrhage from esophageal varices) and seven cases of cancer (one each of prostate, colon, renal papillary, and rectal cancer and three nonmelanoma skin cancers) among 825 patients who received ustekinumab and no deaths and one case of cancer (testicular cancer) among 319 patients who received placebo.Ustekinumab was more effective than placebo for inducing and maintaining remission in patients with moderate-to-severe ulcerative colitis. (Funded by Janssen Research and Development; UNIFI ClinicalTrials.gov number, NCT02407236.).
Impaired Ang II mediated activation of ERK1/ERK2 and SAPK/JNK pathways with normal AT1 receptor binding and mRNA expression in myocytes from failing human hearts Pietro A. Modesti, Simone Vanni, Brunella Bandinelli, Rita Paniccia, Iacopo Bertolozzi, Gianluca Polidori, Ilaria Cecioni, Gian Gastone Neri Serneri. Clinica Medica Generale e Cardiologia, Florence, Italy
Journal: Journal of the American College of Cardiology (2001)