tbuckley/cabot-search huggingface dataset:
N-of-1 Trial Finds No Effect of Statins on Muscle Symptoms
Authors: Anita Slomski
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOLUBLE ST2 AND ITS ASSOCIATION WITH ECHOCARDIOGRAPHIC MEASURES OF DIASTOLIC DYSFUNCTION IN AMBULATORY PATIENTS WITH HFPEF
Authors: Alexander Gong, James O. Onwuzurike, Nina Balac, Sagar V. Patel, Jina Sohn, Luanda P. Grazette
Journal: Journal of the American College of Cardiology (2021)
ENDOGENOUS ACTIVATION OF THROMBIN GENERATION IN ATRIAL FIBRILLATION AND ITS RELEVANCE TO PROTHROMBIN FRAGMENT 1.2 AND D-DIMER
Authors: Fakiha Siddiqui, Mushabbar Syed, Emily Bontekoe, Debra Hoppensteadt, Amir Darki, Keaton Wieschhaus, Omer Iqbal, Jeffrey Liles, Jawed Fareed
Journal: Journal of the American College of Cardiology (2021)
Corinne Alison Rees
Authors: Gareth Rees
Journal: BMJ (2021)

Corinne Alison Rees (nee Illingworth) often stressed the importance of listening and believed that diminishing the roles of careful history taking and clinical examination carries considerable risk. She was wary of increasing specialisation and overreliance on investigations and protocols: she was always ready to challenge orthodoxy. She thought that safe practice should be as robust in addressing gaps in knowledge as in applying knowledge prudently. She maintained that friendliness, thinking about the wider picture, and using common sense are crucial to good doctoring. Feedback from children, adoptive parents, and colleagues showed she practised what she preached.

Corinne was the youngest of three children in a medical family. Her father, Ronald Illingworth, was the first professor of child health in Sheffield, an internationally renowned paediatrician and prolific author. Her mother, Cynthia, was the first paediatric accident and emergency consultant in the UK. All three children qualified as doctors, married doctors, and became fellows of the Royal College of Physicians.

Corinne grew up with a love of the countryside, especially hills and mountains, lakes and fjords, developed through family outings to the Peak District and holidays in the Lake District, Scotland, the Alps, and Norway. She was a Queen’s Guide, deputy head girl …
THE RISK OF CANCER AFTER ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION
Authors: Nathalie I. Bouwer, Mark-David Levin, Auke P. J.D. Weevers, M. Arfan Ikram, Eric Boersma, Jaap W. Deckers, Maarten J.G. Leening
Journal: Journal of the American College of Cardiology (2021)
Deep Learning Estimation of 10-2 and 24-2 Visual Field Metrics Based on Thickness Maps from Macula OCT
Authors: Mark Christopher, Christopher Bowd, James A. Proudfoot, Akram Belghith, Michael H. Goldbaum, Jasmin Rezapour, Massimo A. Fazio, Christopher A. Girkin, Gustavo De Moraes, Jeffrey M. Liebmann, Robert N. Weinreb, Linda M. Zangwill
Journal: Ophthalmology (2021)
Predicting In-Hospital Mortality in Patients Undergoing Percutaneous Coronary Intervention
Authors: Yulanka S. Castro-Dominguez, Yongfei Wang, Karl E. Minges, Robert L. McNamara, John A. Spertus, Gregory J. Dehmer, John C. Messenger, Kimberly Lavin, Cornelia Anderson, Kristina Blankinship, Nestor Mercado, Julie M. Clary, Anwar D. Osborne, Jeptha P. Curtis, Matthew A. Cavender
Journal: Journal of the American College of Cardiology (2021)
LONG-TERM OUTCOMES OF STEMI PATIENTS WITH DIABETES MELLITUS: INSIGHTS FROM THE MIDWEST STEMI CONSORTIUM
Authors: Michael Megaly, Christian Schmidt, Marshall Dworak, Ross Garberich, Larissa Stanberry, Scott Sharkey, Emmanouil Brilakis, Frank Aguirre, Roberto Pacheco, Mark Tannenbaum, Teresa Coulson, Raviteja Guddeti, Timothy Smith, Timothy Henry, Santiago Garcia
Journal: Journal of the American College of Cardiology (2021)
The blueprint of disaster: COVID-19, the Flint water crisis, and unequal ecological impacts
Authors: Jerel M Ezell, Delilah Griswold, Elizabeth C Chase, Evan Carver
Journal: The Lancet Planetary Health (2021)

COVID-19 is unique in the scope of its effects on morbidity and mortality. However, the factors contributing to its disparate racial, ethnic, and socioeconomic effects are part of an expansive and continuous history of oppressive social policy and marginalising geopolitics. This history is characterised by institutionally generated spatial inequalities forged through processes of residential segregation and neglectful urban planning. In the USA, aspects of COVID-19's manifestation closely mirror elements of the build-up and response to the Flint crisis, Michigan's racially and class-contoured water crisis that began in 2014, and to other prominent environmental injustice cases, such as the 1995 Chicago (IL, USA) heatwave that severely affected the city's south and west sides, predominantly inhabited by Black people. Each case shares common macrosocial and spatial characteristics and is instructive in showing how civic trust suffers in the aftermath of public health disasters, becoming especially degenerative among historically and spatially marginalised populations. Offering a commentary on the sociogeographical dynamics that gave rise to these crises and this institutional distrust, we discuss how COVID-19 has both inherited and augmented patterns of spatial inequality. We conclude by outlining particular steps that can be taken to prevent and reduce spatial inequalities generated by COVID-19, and by discussing the preliminary steps to restore trust between historically disenfranchised communities and the public officials and institutions tasked with responding to COVID-19.
Questions About DNR Orders
Authors: Bernard Lo
Journal: JAMA (1991)

<h3>In Reply.</h3> —We agree with Ventres and Nichter that physicians need to appreciate the concerns and images that patients and families have about cardiopulmonary resuscitation. Leivers raises the important issue of DNR orders in the operating room, particularly in patients undergoing palliative surgery. We agree that decisions about resuscitation in this setting need to be discussed before surgery and documented clearly. Furthermore, it would be appropriate to discuss before the operation what should be done if postoperative complications develop and cannot be successfully treated. Decisions should be individualized and should respect both the patient's preferences and the anesthesiologist's or surgeon's own ethical principles. As in this case, some mutually acceptable plan is usually possible. Our natural reaction as physicians to intervene, to try to correct iatrogenic illness, should be tempered if a patient chooses to forgo the maximum application of medical technology.
Functional electrical stimulation‐assisted cycle ergometry-based progressive mobility programme for mechanically ventilated patients: randomised controlled trial with 6 months follow-up
Authors: Petr Waldauf, Natália Hrušková, Barbora Blahutova, Jan Gojda, Tomáš Urban, Adéla Krajčová, Michal Fric, Kateřina Jiroutková, Kamila Řasová, František Duška
Journal: Thorax (2021)

Purpose Functional electrical stimulation-assisted cycle ergometry (FESCE) enables in-bed leg exercise independently of patients’ volition. We hypothesised that early use of FESCE-based progressive mobility programme improves physical function in survivors of critical care after 6 months. Methods We enrolled mechanically ventilated adults estimated to need &gt;7 days of intensive care unit (ICU) stay into an assessor-blinded single centre randomised controlled trial to receive either FESCE-based protocolised or standard rehabilitation that continued up to day 28 or ICU discharge. Results We randomised in 1:1 ratio 150 patients (age 61±15 years, Acute Physiology and Chronic Health Evaluation II 21±7) at a median of 21 (IQR 19–43) hours after admission to ICU. Mean rehabilitation duration of rehabilitation delivered to intervention versus control group was 82 (IQR 66–97) versus 53 (IQR 50–57) min per treatment day, p&lt;0.001. At 6 months 42 (56%) and 46 (61%) patients in interventional and control groups, respectively, were alive and available to follow-up (81.5% of prespecified sample size). Their Physical Component Summary of SF-36 (primary outcome) was not different at 6 months (50 (IQR 21–69) vs 49 (IQR 26–77); p=0.26). At ICU discharge, there were no differences in the ICU length of stay, functional performance, rectus femoris cross-sectional diameter or muscle power despite the daily nitrogen balance was being 0.6 (95% CI 0.2 to 1.0; p=0.004) gN/m 2 less negative in the intervention group. Conclusion Early delivery of FESCE-based protocolised rehabilitation to ICU patients does not improve physical functioning at 6 months in survivors. Trial registration number NCT02864745 .
Pancytopenia in a Patient With Metastatic Well-Differentiated Neuroendocrine Tumor After Peptide Receptor Radionuclide Therapy
Authors: Satya Das, Jordan Berlin, Michael Savona
Journal: JAMA Oncology (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Immune cell composition and functional marker dynamics from multiplexed immunohistochemistry to predict response to neoadjuvant chemotherapy in the WSG-ADAPT-TN trial
Authors: Monika Graeser, Friedrich Feuerhake, Oleg Gluz, Valery Volk, Michael Hauptmann, Katarzyna Jozwiak, Matthias Christgen, Sherko Kuemmel, Eva-Maria Grischke, Helmut Forstbauer, Michael Braun, Mathias Warm, John Hackmann, Christoph Uleer, Bahriye Aktas, Claudia Schumacher, Cornelia Kolberg-Liedtke, Ronald Kates, Rachel Wuerstlein, Ulrike Nitz, Hans Heinrich Kreipe, Nadia Harbeck
Journal: Journal for ImmunoTherapy of Cancer (2021)

Background The association of early changes in the immune infiltrate during neoadjuvant chemotherapy (NACT) with pathological complete response (pCR) in triple-negative breast cancer (TNBC) remains unexplored. Methods Multiplexed immunohistochemistry was performed in matched tumor biopsies obtained at baseline and after 3 weeks of NACT from 66 patients from the West German Study Group Adjuvant Dynamic Marker-Adjusted Personalized Therapy Trial Optimizing Risk Assessment and Therapy Response Prediction in Early Breast Cancer - Triple Negative Breast Cancer (WSG-ADAPT-TN) trial. Association between CD4, CD8, CD73, T cells, PD1-positive CD4 and CD8 cells, and PDL1 levels in stroma and/or tumor at baseline, week 3 and 3-week change with pCR was evaluated with univariable logistic regression. Results Compared with no change in immune cell composition and functional markers, transition from ‘cold’ to ‘hot’ (below-median and above-median marker level at baseline, respectively) suggested higher pCR rates for PD1-positive CD4 (tumor: OR=1.55, 95% CI 0.45 to 5.42; stroma: OR=2.65, 95% CI 0.65 to 10.71) and PD1-positive CD8 infiltrates (tumor: OR=1.77, 95% CI 0.60 to 5.20; stroma: OR=1.25, 95% CI 0.41 to 3.84; tumor+stroma: OR=1.62, 95% CI 0.51 to 5.12). No pCR was observed after ‘hot-to-cold’ transition in PD1-positive CD8 cells. pCR rates appeared lower after hot-to-cold transitions in T cells (tumor: OR=0.26, 95% CI 0.03 to 2.34; stroma: OR=0.35, 95% CI 0.04 to 3.25; tumor+stroma: OR=0.00, 95% CI 0.00 to 1.04) and PD1-positive CD4 cells (tumor: OR=0.60, 95% CI 0.11 to 3.35; stroma: OR=0.22, 95% CI 0.03 to 1.92; tumor+stroma: OR=0.32, 95% CI 0.04 to 2.94). Higher pCR rates collated with ‘altered’ distribution (levels below-median and above-median in tumor and stroma, respectively) of T cell (OR=3.50, 95% CI 0.84 to 14.56) and PD1-positive CD4 cells (OR=4.50, 95% CI 1.01 to 20.14). Conclusion Our exploratory findings indicate that comprehensive analysis of early immune infiltrate dynamics complements currently investigated predictive markers for pCR and may have a potential to improve guidance for individualized de-escalation/escalation strategies in TNBC.
Platelet heterogeneity enhances blood clot volumetric contraction: An example of asynchrono-mechanical amplification
Authors: Yueyi Sun, David R. Myers, Svetoslav V. Nikolov, Oluwamayokun Oshinowo, John Baek, Samuel M. Bowie, Tamara P. Lambert, Eric Woods, Yumiko Sakurai, Wilbur A. Lam, Alexander Alexeev
Journal: Biomaterials (2021)
Quality of Life in Patients With Heart Failure With Recovered Ejection Fraction
Authors: Peter Wohlfahrt, Jose Nativi-Nicolau, Mingyuan Zhang, Craig H. Selzman, Thomas Greene, Jorge Conte, Joshua E. Biber, Rachel Hess, Favel L. Mondesir, Omar Wever-Pinzon, Stavros G. Drakos, Edward M. Gilbert, Line Kemeyou, Bernie LaSalle, Benjamin A. Steinberg, Rashmee U. Shah, James C. Fang, John A. Spertus, Josef Stehlik
Journal: JAMA Cardiology (2021)

Heart failure with recovered ejection fraction (HFrecEF) is a recently recognized phenotype of patients with a history of reduced left ventricular ejection fraction (LVEF) that has subsequently normalized. It is unknown whether such LVEF improvement is associated with improvements in health status.To examine changes in health-related quality of life in patients with heart failure with reduced ejection fraction (HFrEF) whose LVEF normalized, compared with those whose LVEF remains reduced and those with HF with preserved EF (HFpEF).This prospective cohort study was conducted at a tertiary care hospital from November 2016 to December 2018. Consecutive patients seen in a heart failure clinic who completed patient-reported outcome assessments were included. Clinical data were abstracted from the electronic health record. Data analysis was completed from February to December 2020.Changes in Kansas City Cardiomyopathy Questionnaire overall summary score, Visual Analog Scale score, and Patient-Reported Outcomes Measurement Information System domain scores on physical function, fatigue, depression, and satisfaction with social roles over 1-year follow-up.The study group included 319 patients (mean [SD] age, 60.4 [15.5] years; 120 women [37.6%]). At baseline, 212 patients (66.5%) had HFrEF and 107 (33.5%) had HFpEF. At a median follow-up of 366 (interquartile range, 310-421) days, LVEF had increased to 50% or more in 35 patients with HFrEF (16.5%). Recovery of systolic function was associated with heart failure-associated quality-of-life improvement, such that for each 10% increase in LVEF, the Kansas City Cardiomyopathy Questionnaire score improved by an mean (SD) of 4.8 (1.6) points (P = .003). Recovery of LVEF was also associated with improvement of physical function, satisfaction with social roles, and a reduction in fatigue.Among patients with HFrEF in this study, normalization of left ventricular systolic function was associated with a significant improvement in health-related quality of life.
THE FIRST ADULT CONGENITAL HEART DISEASE REGISTRY IN THE CARIBBEAN
Authors: Monica Rosario, Aaron Villegas, Humberto Gómez, Nicole Vasquez, Gloria Hermón, Pamela Piña, Adabeyda Báez, Rebeca Pérez, Dhamelisse Then, Janet Toribio, Cesar Herrera
Journal: Journal of the American College of Cardiology (2021)
Next‐generation sequencing and genotype association studies reveal the association of <i>HLA‐DRB3*02:02</i> with delayed hypersensitivity to penicillins
Authors: Antonino Romano, Abderrahim Oussalah, Celine Chery, Rosa‐Maria Guéant‐Rodriguez, Francesco Gaeta, Jose‐Antonio Cornejo‐Garcia, Pierre Rouyer, Thomas Josse, Cristobalina Mayorga, Maria‐Jose Torres, Jean‐Louis Guéant
Journal: Allergy (2021)

Nonimmediate (delayed)-allergic reactions to penicillins are common and some of them can be life-threatening. The genetic factors influencing these reactions are unknown/poorly known/poorly understood. We assessed the genetic predictors of a delayed penicillin allergy that cover the HLA loci.Using next-generation sequencing (NGS), we genotyped the MHC region in 24 patients with delayed hypersensitivity compared with 20 patients with documented immediate hypersensitivity to penicillins recruited in Italy. Subsequently, we analyzed in silico Illumina Immunochip genotyping data that covered the HLA loci in 98 Spanish patients with delayed hypersensitivity and 315 with immediate hypersensitivity compared to 1,308 controls.The two alleles DRB3*02:02:01:02 and DRB3*02:02:01:01 were reported in twenty cases with delayed reactions (83%) and ten cases with immediate reactions (50%), but not in the Allele Frequency Net Database. Bearing at least one of the two alleles increased the risk of delayed reactions compared to immediate reactions, with an OR of 8.88 (95% CI, 3.37-23.32; p < .0001). The haplotype (ACAA) from rs9268835, rs6923504, rs6903608, and rs9268838 genetic variants of the HLA-DRB3 genomic region was significantly associated with an increased risk of delayed hypersensitivity to penicillins (OR, 1.7; 95% CI: 1.06-1.92; p = .001), but not immediate hypersensitivity.We showed that the HLA-DRB3 locus is strongly associated with an increased risk of delayed penicillin hypersensitivity, at least in Southwestern Europe. The determination of HLA-DRB3*02:02 alleles in the risk management of severe delayed hypersensitivity to penicillins should be evaluated further in larger population samples of different origins.
CRUSHED VERSUS INTEGRAL P2Y12 INHIBITORS LOADING IN MANAGEMENT OF STEMI PATIENTS UNDERGOING PRIMARY PERCUTANEOUS CORONARY INTERVENTION: A SYSTEMATIC REVIEW AND METAANALYSIS OF RANDOMIZED CONTROLLED TRIALS
Authors: Ahmed Elzanaty, Eman Elsheikh, Sapan Bhuta, Neha Patel, Mahmoud Khalil, Salik Nazir, Mohammed Mhanna, Sami Ghazaleh, Azizullah Beran, Ehab Eltahawy
Journal: Journal of the American College of Cardiology (2021)
RACIAL/ETHNIC DIFFERENCES IN RISK FACTORS, TREATMENTS, AND OUTCOMES IN YOUNG ADULTS PRESENTING WITH ACUTE MYOCARDIAL INFARCTION
Authors: Sarah Chiu, Malini Nadadur, Derek Phan, Bryan Lin, Bryant Hammershaimb, Karo Gyurjian, Yuh-Jer Shen, Ming Sum Lee
Journal: Journal of the American College of Cardiology (2021)
CALF SKELETAL MUSCLE MICROVASCULAR REACTIVITY MEASURED BY BLOOD OXYGEN LEVEL DEPENDENT (BOLD) MAGNETIC RESONANCE IMAGING PREDICTS WALKING ENDURANCE IN SUBJECTS WITH PERIPHERAL ARTERY DISEASE
Authors: Adam Behroozian, Manus J. Donahue, Crystal Coolbaugh, Jorge Gamboa, Emily Shardelow, Joshua Beckman
Journal: Journal of the American College of Cardiology (2021)
CATHAI: FULLY AUTOMATED CORONARY ANGIOGRAPHY INTERPRETATION AND STENOSIS DETECTION USING A DEEP LEARNING-BASED ALGORITHMIC PIPELINE
Authors: Robert Avram, Jeffrey Olgin, Alvin Wan, Zeeshan Ahmed, Louis Verreault-Julien, Sean Abreau, Derek Wan, Joseph E. Gonzalez, Derek So, Krishan Soni, Geoffrey Tison
Journal: Journal of the American College of Cardiology (2021)
Multicenter Case Series of Primary Adrenal Lymphoma (PAL)
Authors: Fatemeh Majidi, Samuela Martino, Matthias Haase, Vasileios Chortis, Wiebke Arlt, Cristina Lucia Ronchi, Martin Fassnacht, Claire Laurent, Olivier Casasnovas, Jean-Michel Petit, Mouhammed Amir Habra, Aleem Kanji, Roberto Salvatori, An Thi Nhat Ho, Ariadni Spyroglou, Felix Beuschlein, Martina Rudelius, Matthias Schott, Ulrich Germing, Rainer Haas, Norbert Gattermann
Journal: Blood (2017)
Abstract 13501: Thin-Strut Bioresorbable Scaffold Promotes Rapid Arterial Healing Through Endothelial Shear Stress-Mediated Immune Modulation: A Serial Multi-Modal Optical Coherence Tomography-Near Infrared Fluorescence (OCT-NIRF) Molecular Imaging Study
Authors: Sunwon Kim, Hyun-Sang Park, Hyeong Soo Nam, Joon Woo Song, Jeongmoo Han, Jae Won Ahn, Gyounghwan Kim, Yeon Hoon Kim, Hongki Yoo, Kyeongsoon Park, Wang-Yuhl Oh, Jin Won Kim
Journal: Circulation (2019)

Introduction: Stent healing involves a series of cellular reactions such as thrombosis, inflammation, neointimal proliferation, however, there is a lack of in vivo imaging study regarding this proc...
Myelocytomatosis‐Protein Arginine N‐Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma
Authors: Yuhong Luo, Yuqing Gao, Weiwei Liu, Yuan Yang, Jie Jiang, Ying Wang, Wei Tang, Shoumei Yang, Lulu Sun, Jie Cai, Xiaozhen Guo, Shogo Takahashi, Kristopher W. Krausz, Aijuan Qu, Lei Chen, Cen Xie, Frank J. Gonzalez
Journal: Hepatology (2021)

Background and Aims HCC is a leading cause of cancer‐related deaths globally with poor outcome and limited therapeutic options. Although the myelocytomatosis ( MYC ) oncogene is frequently dysregulated in HCC, it is thought to be undruggable. Thus, the current study aimed to identify the critical downstream metabolic network of MYC and develop therapies for MYC‐driven HCC. Approach and Results Liver cancer was induced in mice with hepatocyte‐specific disruption of Myc and control mice by administration of diethylnitrosamine. Liquid chromatography coupled with mass spectrometry‐based metabolomic analyses revealed that urinary dimethylarginine, especially symmetric dimethylarginine (SDMA), was increased in the HCC mouse model in an MYC‐dependent manner. Analyses of human samples demonstrated a similar induction of SDMA in the urines from patients with HCC. Mechanistically, Prmt5 , encoding protein arginine N‐methyltransferase 5, which catalyzes SDMA formation from arginine, was highly induced in HCC and identified as a direct MYC target gene. Moreover, GSK3326595, a PRMT5 inhibitor, suppressed the growth of liver tumors in human MYC‐overexpressing transgenic mice that spontaneously develop HCC. Inhibition of PRMT5 exhibited antiproliferative activity through up‐regulation of the tumor suppressor gene Cdkn1b /p27 , encoding cyclin‐dependent kinase inhibitor 1B. In addition, GSK3326595 induced lymphocyte infiltration and major histocompatibility complex class II expression, which might contribute to the enhanced antitumor immune response. Combination of GSK3326595 with anti–programed cell death protein 1 (PD‐1) immune checkpoint therapy (ICT) improved therapeutic efficacy in HCC. Conclusions This study reveals that PRMT5 is an epigenetic executer of MYC, leading to repression of the transcriptional regulation of downstream genes that promote hepatocellular carcinogenesis, highlights a mechanism‐based therapeutic strategy for MYC‐driven HCC by PRMT5 inhibition through synergistically suppressed proliferation and enhanced antitumor immunity, and finally provides an opportunity to mitigate the resistance of “immune‐cold” tumor to ICT.