tbuckley/cabot-search huggingface dataset:
Dynamic Epigenetic Landscapes Define Multiple Myeloma Progression and Drug Resistance
Authors: Rafael Renatino-Canevarolo, Mark B. Meads, Maria Silva, Praneeth Reddy Sudalagunta, Christopher Cubitt, Gabriel De Avila, Raghunandan R Alugubelli, Amit Kulkarni, Qi Zhang, Oliver Hampton, Kenneth H. Shain, Ariosto Siqueira Silva
Journal: Blood (2020)
Abstract 12669: Endocardial Metastasis of Urothelial Carcinoma Masquerading as ST-segment Elevation Myocardial Infarction
Authors: Gary S Ma, Quan M Bui, Lori Daniels
Journal: Circulation (2019)

Cardiac metastasis of urothelial carcinoma is a rare clinical phenomenon seen in 3.9% of cases via post-mortem evaluation and only a handful of case reports involving living patients. We present th...
Pretreatment Next-Generation Sequencing Is Associated with Response to Induction Chemotherapy in Patients Newly Diagnosed with Acute Myeloid Leukemia
Authors: Anastasia Tsagianni, Konstantinos Lontos, Mounzer Agha, Anastasios Raptis, Jing-Zhou Hou, Rafic J. Farah, Robert L. Redner, Annie Im, Kathleen A. Dorritie, Alison R. Sehgal, James M. Rossetti, Melissa Saul, William Gooding, Michael Boyiadzis
Journal: Blood (2020)
Genomic Complexity in Chronic Lymphocytic Leukemia Defined By Array-Based Analysis: Definitions, Associations with Other Biomarkers and Clinical Impact
Authors: Alexander Leeksma, Panagiotis Baliakas, Clemens Mellink, Theodoros Moysiadis, Anna Puiggros, Karla Plevova, Eva van den Berg, Eric Eldering, Aron Skaftason, Larry Mansouri, Rebeqa Gunnarsson, Paolo Ghia, Blanca Espinet, Sarka Pospisilova, Florence Nguyen-Khac, David Oscier, Kostas Stamatopoulos, Claudia Haferlach, Richard Rosenquist, Jonathan C Strefford, Marian Stevens-Kroef, Arnon P. Kater
Journal: Blood (2017)
Prospective Study Reveals Increased Platelet Function Associated with Multiple Myeloma and Its Treatment
Authors: Dalia Khan, Joanne Mitchell, Rekha Rana, Neline Kriek, Amanda Unsworth, Tanya Sage, Michael Laffan, Susie Shapiro, Anjan Thakurta, Karthik Ramasamy, Jonathan Gibbins
Journal: Blood (2020)
Associations between physical frailty and dementia incidence: a prospective study from UK Biobank
Authors: Fanny Petermann-Rocha, Donald M Lyall, Stuart R Gray, Irene Esteban-Cornejo, Terence J Quinn, Frederick K Ho, Jill P Pell, Carlos Celis-Morales
Journal: The Lancet Healthy Longevity (2020)

BackgroundDementia is associated with a high burden of dependency and disability. Physical frailty (hereafter referred to as frailty) is a multisystem dysregulation that has been identified as a risk factor for dementia. The aim of this study was to examine the association of frailty and its individual components with all-cause dementia incidence in a cohort of UK adults.MethodsParticipants in UK Biobank with data available for dementia incidence and without any form of dementia at baseline were included in this prospective study. Frailty was defined using a modified version of the frailty phenotype based on five individual components (weight loss, tiredness, physical activity, gait speed, and grip strength), with participants classified as pre-frail if they fulfilled one or two criteria or frail if they fulfilled three or more. Associations between frailty and dementia incidence were investigated using Cox proportional hazard models adjusted for sociodemographic factors, lifestyle factors, and morbidity count. The population attributable fraction was also estimated.FindingsOf 502 535 participants in UK Biobank, 143 215 met the inclusion criteria and were included in our analyses. 68 500 (47·8%) of the participants were pre-frail and 5565 (3·9%) were frail. During a median follow-up period of 5·4 years, 726 individuals developed dementia. Compared with non-frail individuals, the risk of dementia incidence was increased for individuals with pre-frailty (hazard ratio 1·21 [95% CI 1·04–1·42]) and frailty (1·98 [1·47–2·67]) in the fully adjusted model. Of the five components used to define frailty, weight loss (1·31 [1·09–1·58]), tiredness (1·48 [1·18–1·86]), low grip strength (1·38 [1·17–1·63]), and slow gait speed (1·55 [1·22–1·96]) were independently associated with incident dementia. Based on population attributable fraction analyses, in the study sample, pre-frailty and frailty accounted for 9·9% and 8·6% of dementia cases, respectively.InterpretationIndividuals with pre-frailty and frailty were at a higher risk of dementia incidence even after adjusting for a wide range of confounding factors. Early detection and interventions for frailty could translate into prevention or delayed onset of dementia.FundingNone.
A Phase I Trial Assessing the Feasibility of Romidepsin Combined with Brentuximab Vedotin for Patients Requiring Systemic Therapy for Cutaneous T-Cell Lymphoma
Authors: Stefan K. Barta, Tatyana A. Feldman, Jennifer A. DeSimone, Ellen Kim, Karthik Devajaran, David Wiest, Henry C.H. Fung, Richard I. Fisher, Carlyn Tan, Nadia Khan
Journal: Blood (2020)
Post-Remission Treatment (Tx) Patterns for Patients (Pts) with Newly Diagnosed (ND) Acute Myeloid Leukemia (AML) in the Connect® MDS/AML Disease Registry
Authors: Gail J. Roboz, Christopher R. Cogle, Daniel A. Pollyea, Mehrdad Abedi, Michael A. Thompson, Melissa Nifenecker, E. Dawn Flick, Pavel Kiselev, Chrystal U. Louis, Michelle Little, Harry P. Erba
Journal: Blood (2020)
Quality of Life after Diagnosis in Survivors of Aggressive Lymphomas
Authors: Robert M. Kraft, Melissa C. Larson, Kathleen J. Yost, Thomas M. Habermann, Matthew J. Maurer, William R. Macon, Umar Farooq, David J. Inwards, Gita Thanarajasingam, Brian K. Link, James R. Cerhan, Carrie A. Thompson
Journal: Blood (2020)
Ubiquitinome Profiling Reveals the Landscape of Ubiquitination Regulation in Rice Young Panicles
Authors: Liya Zhu, Han Cheng, Guoqing Peng, Shuansuo Wang, Zhiguo Zhang, Erdong Ni, Xiangdong Fu, Chuxiong Zhuang, Zexian Liu, Hai Zhou
Journal: Genomics Proteomics & Bioinformatics (2020)

Abstract Ubiquitination, an essential post-transcriptional modification (PTM), plays a vital role in nearly every biological process, including development and growth. Despite its functions in plant reproductive development, its targets in rice panicles remain unclear. In this study, we used proteome-wide profiling of lysine ubiquitination in rice (O. sativa ssp. indica) young panicles. We created the largest ubiquitinome dataset in rice to date, identifying 1638 lysine ubiquitination sites on 916 unique proteins. We detected three conserved ubiquitination motifs, noting that acidic glutamic acid (E) and aspartic acid (D) were most frequently present around ubiquitinated lysine. Enrichment analysis of Gene Ontology (GO) annotations and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of these ubiquitinated proteins revealed that ubiquitination plays an important role in fundamental cellular processes in rice young panicles. Interestingly, enrichment analysis of protein domains indicated that ubiquitination was enriched on a variety of receptor-like kinases and cytoplasmic tyrosine and serine-threonine kinases. Furthermore, we analyzed the crosstalk between ubiquitination, acetylation, and succinylation, and constructed a potential protein interaction network within our rice ubiquitinome. Moreover, we identified ubiquitinated proteins related to pollen and grain development, indicating that ubiquitination may play a critical role in the physiological functions in young panicles. Taken together, we reported the most comprehensive lysine ubiquitinome in rice so far, and used it to reveal the functional role of lysine ubiquitination in rice young panicles.
Cytokine-Induced Memory-like NK Cells Exhibit Massive Expansion and Long-Term Persistence after Infusion Post-Haploidentical Stem Cell Transplantation: A Report of the First Three Cases in a Phase I Trial
Authors: Roman M Shapiro, Sarah Nikiforow, Benedetta Rambaldi, Juliana Vergara, Heather Daley, Haesook T. Kim, Corey Cutler, Vincent T. Ho, John Koreth, Mahasweta Gooptu, Joseph H. Antin, Jennifer Brock, Catherine J. Wu, Robert J. Soiffer, Jerome Ritz, Rizwan Romee
Journal: Blood (2020)
Dietary Supplement Use in Children and Adolescents Aged ≤19 Years — United States, 2017–2018
Authors: Bryan Stierman, Suruchi Mishra, Jaime J. Gahche, Nancy Potischman, Craig M. Hales
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

Dietary supplement use is common among children and adolescents. During 2013-2014, approximately one third of children and adolescents (persons aged ≤19 years) in the United States were reported to use a dietary supplement in the past 30 days, and use varied by demographic characteristics (1,2). Dietary supplements can contribute substantially to overall nutrient intake, having the potential to both mitigate nutrient shortfalls as well as to lead to nutrient intake above recommended upper limits (3). However, because nutritional needs should generally be met through food consumption according to the 2015-2020 Dietary Guidelines for Americans, only a few dietary supplements are specifically recommended for use among children and adolescents and only under particular conditions (4). The most recently released data from the National Health and Nutrition Examination Survey (NHANES) during 2017-2018 were used to estimate the prevalence of use among U.S. children and adolescents of any dietary supplement, two or more dietary supplements, and specific dietary supplement product types. Trends were calculated for dietary supplement use from 2009-2010 to 2017-2018. During 2017-2018, 34.0% of children and adolescents used any dietary supplement in the past 30 days, with no significant change since 2009-2010. Use of two or more dietary supplements increased from 4.3% during 2009-2010 to 7.1% during 2017-2018. Multivitamin-mineral products were used by 23.8% of children and adolescents, making these the products most commonly used. Because dietary supplement use is common, surveillance of dietary supplement use, combined with nutrient intake from diet, will remain an important component of monitoring nutritional intake in children and adolescents to inform clinical practice and dietary recommendations.
Safety and Efficacy of Salvage Therapies for Relapse/Refractory AML/MDS after First Allogeneic Hematopoietic Stem Cell Transplant: A Systematic Review
Authors: Farwah N. Fatima, Muhammad Ashar Ali, Anum Javaid, Rimsha Ali, Aqsa Mumtaz, Wajeeha Aiman, Nayab Mirza, Sana Khan, Hamza Hashmi, Faiz Anwer
Journal: Blood (2020)
FRI0146 Deforming arthropathy of the hands (jaccoud?s arthropathy) in 20 patients with systemic lupus erythematosus (sle)
Authors: G Hayem, F Roux, SA Rouidi, E Palazzo, M Debandt, MF Kahn, O Meyer
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> Jaccoud?s arthropathy (JA) is a deforming but non erosive arthropathy that can affect patients with systemic lupus erythematosus (SLE). <h3>Objectives</h3> To characterise SLE-associated JA (SLE-JA), and to compare the clinical and laboratory manifestations of SLE patients, with or without JA. <h3>Methods</h3> From our cohort of 860 SLE patients, we selected all patients with clinical JA, as well as 86 patients without JA. Patients with erosive arthropathy were excluded. Clinical and laboratory manifestations were compared between the two groups. <h3>Results</h3> We found 20 patients with SLE-JA (19 females, 1 male, all caucasians). Their mean age at SLE onset was 29.3 ± 12.5 yrs; mean duration of arthritis was 20.1 ± 8.6 yrs; mean number of 1982 ARA criteria for SLE was 5.9 ± 1.5 (range 4–9). Main deformations were ulnar drift (75%), swan neck deformities (85%), Z deformity of the thumbs (80%) and boutonniere deformities (5%). JA of the feet was present in 4 patients, with hallux valgus (15%) or hammer toes (5%) deformities. Major hyperlaxity of other joints was noted in 2 patients (10%) and tendon rupture in 5 (25%). Five patients underwent hand surgery for correction of deformities. Compared to SLE cases without JA, patients with SLE-JA had a higher frequency of Raynaud's phenomenon (50% vs 15%; p &lt; 0.002) and IgM rheumatoid factor positivity (37% vs 15%; p &lt; 0.04), and a lower frequency of lymphopenia (45% vs 71%; p &lt; 0.03). No SLE-JA patient had antikeratin or antiperinuclear antibodies (ab). Anti-RA33 ab was absent in all 14 SLE-JA patients tested. The prevalence of other manifestations, including those related to antiphospholipid syndrome or SJÖGREN'S syndrome, was not different in the two groups. <h3>Conclusion</h3> SLE-JA seems a rare condition. Rheumatoid factor inconstantly identifies this SLE subset, but the absence of other RA-associated ab, such as antifilaggrin ab, helps to differentiate SLE-JA from RA associated with SLE.
Abstract 225: Coordinated Transcriptome and Cell State Dynamics of Non-myocytes in Heart Regeneration
Authors: Hong Ma, Ziqing Liu, Yuchen Yang, Dong Feng, Yanhan Dong, Andrea A Rivis, Tiffany A Garbutt, Zhiyuan Hu, Li Wang, Cynthia D Cooper, Yun Li, Welch Joshua, Li Qian, Jiandong Liu
Journal: Circulation Research (2020)

Cardiac regeneration occurs primarily through proliferation of existing cardiomyocytes, yet the regenerative response also involves complex interactions between distinct cardiac cell types including not only cardiomyocytes, but also non-cardiomyocytes (nonCMs). However, the subpopulations, distinguishing molecular features, cellular functions, and intercellular interactions of nonCMs in heart regeneration remain largely unexplored. Using the LIGER algorithm, we assembled an atlas of cell states from 61,977 individual nonCM scRNA-seq profiles isolated at multiple time points during heart regeneration in both wildtype and mutant fish. This analysis revealed extensive nonCM cell diversity, including multiple macrophage, fibroblast and endothelial subpopulations with unique spatiotemporal distributions and cooperative interactions during the process of cardiac regeneration. Genetic and pharmacological perturbation of macrophage functional dynamics compromised interactions among nonCM subpopulations, reduced cardiomyocyte proliferation, and caused defective cardiac regeneration. Furthermore, we developed a computational algorithm called Topologizer to map the topological relationships and dynamics of nonCMs during heart regeneration. We uncovered dynamic transitions between macrophage functional states and identified factors involved in mRNA processing and transcriptional regulation associated with the transition. Together, our single-cell transcriptomic analysis of nonCMs during cardiac regeneration provides a blueprint for interrogating the molecular and cellular basis of cardiac regeneration.
Ultra-low Dose Aerosol Infection of Mice with Mycobacterium tuberculosis More Closely Models Human Tuberculosis
Authors: Courtney R. Plumlee, Fergal J. Duffy, Benjamin H. Gern, Jared L. Delahaye, Sara B. Cohen, Caleb R. Stoltzfus, Tige R. Rustad, Scott G. Hansen, Michael K. Axthelm, Louis J. Picker, John D. Aitchison, David R. Sherman, Vitaly V. Ganusov, Michael Y. Gerner, Daniel E. Zak, Kevin B. Urdahl
Journal: Cell Host & Microbe (2020)
Cxcl8/PKC Signaling in the Endothelial Cell Niche Regulates Long-Term Hematopoietic Stem Cell Fate
Authors: Jami L Shaffer, Donn L Calkins, Emily M Teets, Muhammad Faisal, William Deruelle, Elliott J. Hagedorn, Julie R. Perlin, Serine Avagyan, Leonard I. Zon, Bradley W Blaser
Journal: Blood (2020)
Abstract 344: Circulating MicroRNA Signature as a Predictive Biomarker for Postoperative Heart Failure
Authors: Farhan Rizvi, Stacie Kroboth, Larisa Emelyanova, Gracious R Ross, Maharaj Singh, David Kress, A. Jamil Tajik, Arshad Jahangir
Journal: Circulation Research (2020)

Background: Advancements in cardiac surgical techniques have led to decreasing operative risk. However, postoperative heart failure (PoHF) continues to be a major risk factor for adverse cardiac events in 20-35% of patients after cardiac surgery, with a 10-fold increase in 30-day mortality. Prediction of PoHF is challenging, particularly in patients with preserved ventricular function. Circulating microRNAs (miRNAs) recently were identified to predict HF or AF after surgery, but their role in predicting PoHF is not known. This study aimed to find novel noninvasive circulating biomarkers along with clinical factors that can identify patients at risk of developing PoHF immediately after surgery. Methods: Patients undergoing CABG surgery with no previous history of HF, ventricular or supraventricular tachycardia were recruited, and preoperative blood assessed for circulating levels of protein biomarkers using ELISA. Differences in relative plasma levels of 13 miRNAs between the PoHF and no-PoHF groups were assessed by qPCR. Preoperative echocardiography was obtained. SAS was used for statistical analysis and ROC curve. Results: Out of 68 patients, 13 developed PoHF (19.1%, mean age 64.1±11.6y, 53.8% males), whereas 55 (mean age 68.3±12.4y) remained free of HF. Patients who developed PoHF had lower LVEF (51.4±13.7 vs 58.2±9.9, P&lt;0.05) with no differences in prevalence of hypertension, diabetes, hyperlipidemia, obesity, previous myocardial infarction, stroke, COPD, sleep apnea, or use of cardiac medications. The correlation matrix of all 13 miRNAs was transformed in a principal component (PC), resulting in 3 main clusters with eigenvalue &gt;1. PC cluster2 consisted of miR-23a, -23b, -25 and -26a2, principally involved in oxidatives stress, fibrosis and contractility, and had the strongest association (AUC=0.797; P&lt;0.01) with PoHF. A model combining PC cluster2 with age and LVEF improved sensitivity and specificity of the model to identify patients at risk of PoHF (AUC=0.880; 95% CL, 0.761-0.991; P&lt;0.001) Conclusion: Our study demonstrates that miR-23a, -23b, -25 and -26a2 may be useful predictors of PoHF. Circulating miRNA as biomarkers may have diagnostic potential to preoperatively, noninvasively identify patients at risk of developing PoHF.
Dissecting Multicellular Ecosystems of HTLV-1 Infection and ATL By Multi-Omics Single Cell Analysis
Authors: Junji Koya, Yuki Saito, Takuro Kameda, Yasunori Kogure, Marni B McClure, Sumito Shingaki, Mariko Tabata, Ayako Kamiunten, Kotaro Shide, Kazuya Shimoda, Keisuke Kataoka
Journal: Blood (2020)
Bone Marrow Infiltration at Diffuse Large B-Cell Lymphoma NOS Diagnosis: Comparative Study between PET, Histology and Flow Cytometry
Authors: Fernando Martin Moro, Miguel Piris-Villaespesa, Juan Marquet Palomanes, Claudia Lopez Prieto, Federico Santiago Herrera, Maria Isabel Delgado Trillo, Monica Garcia-Cosio, Alberto Martinez Lorca, Ana Lario Arribas, Ernesto Roldan Santiago, Eulalia Rodriguez Martin, Jose A. Garcia-Marco, Javier Lopez Jimenez, Jose Antonio Garcia Vela
Journal: Blood (2020)
Impact of COVID19 Pandemic on an International MPN Patient Population: Survey Results from 1560 MPN Patients
Authors: Jeanne M. Palmer, Carolyn Mead-Harvey, Claire Harrison, Amylou C. Dueck, Ryan Eckert, Heidi E. Kosiorek, Pablo Muxi, Naveen Pemmaraju, Guillermo Ruiz Arguelles, Alessandro M. Vannucchi, Vikas Gupta, John Mascarenhas, Kerry Taylor, Krisstina L. Gowin, Holly L. Geyer, Kazuya Shimoda, Jean-Jacques Kiladjian, Norio Komatsu, Grace Kam Li Shan, Virginia Abello, David Gomez-Almaguer, Robyn M. Scherber, Qian Jiang, Xuelan Zuo, Jennifer Huberty, Lesley Anderson, Blake T. Langlais, Ann Brazeau, Michelle Woehrle, Michael J. Mauro, Ruben Mesa
Journal: Blood (2020)
VRd Versus KRd Safety Profiles in Newly Diagnosed Multiple Myeloma Patients Using Real-World Evidence Data from a Single Institution: VRd Has High Rates of Chronic Neuropathy, and KRd Has Low Rates of Cardiopulmonary or Renal Toxicities When Using Optimized IV Fluid Management Coupled with Baseline Cardiac Workup
Authors: Carlyn Tan, Benjamin Diamond, Malin Hultcrantz, Neha Korde, Alexander M. Lesokhin, Sham Mailankody, Hani Hassoun, Urvi A Shah, Sydney X. Lu, Dhwani Patel, Heather J Landau, Michael Scordo, David J. Chung, Gunjan Shah, Oscar B Lahoud, Andriy Derkach, Sergio A. Giralt, Ola Landgren
Journal: Blood (2020)
New directions for emerging therapies in acute myeloid leukemia: the next chapter
Authors: Naval Daver, Andrew H. Wei, Daniel A. Pollyea, Amir T. Fathi, Paresh Vyas, Courtney D. DiNardo
Journal: Blood Cancer Journal (2020)

Abstract Conventional therapy for acute myeloid leukemia is composed of remission induction with cytarabine- and anthracycline-containing regimens, followed by consolidation therapy, including allogeneic stem cell transplantation, to prolong remission. In recent years, there has been a significant shift toward the use of novel and effective, target-directed therapies, including inhibitors of mutant FMS-like tyrosine kinase 3 (FLT3) and isocitrate dehydrogenase (IDH), the B-cell lymphoma 2 inhibitor venetoclax, and the hedgehog pathway inhibitor glasdegib. In older patients the combination of a hypomethylating agent or low-dose cytarabine, venetoclax achieved composite response rates that approximate those seen with standard induction regimens in similar populations, but with potentially less toxicity and early mortality. Preclinical data suggest synergy between venetoclax and FLT3- and IDH-targeted therapies, and doublets of venetoclax with inhibitors targeting these mutations have shown promising clinical activity in early stage trials. Triplet regimens involving the hypomethylating agent and venetoclax with FLT3 or IDH1/2 inhibitor, the TP53-modulating agent APR-246 and magrolimab, myeloid cell leukemia-1 inhibitors, or immune therapies such as CD123 antibody-drug conjugates and programmed cell death protein 1 inhibitors are currently being evaluated. It is hoped that such triplets, when applied in appropriate patient subsets, will further enhance remission rates, and more importantly remission durations and survival.
Interim Analysis of ZUMA-12: A Phase 2 Study of Axicabtagene Ciloleucel (Axi-Cel) as First-Line Therapy in Patients (Pts) With High-Risk Large B Cell Lymphoma (LBCL)
Authors: Sattva S. Neelapu, Michael Dickinson, Matthew L. Ulrickson, Olalekan O. Oluwole, Alex F. Herrera, Catherine Thieblemont, Chaitra S. Ujjani, Yi Lin, Peter A. Riedell, Natasha Kekre, Sven de Vos, Yin Yang, Francesca Milletti, Lovely Goyal, Jun Kawashima, Julio C. Chavez
Journal: Blood (2020)