tbuckley/cabot-search huggingface dataset:
Uptake of 99mTc-DTPA in Bone Metastases from Renal Cancer
Authors: Taisong Wang, Jinhua Zhao, Yan Xing
Journal: Clinical Nuclear Medicine (2015)

A 67-year-old man with left renal cell carcinoma underwent Tc-DTPA renal scintigraphy to evaluate the kidney function. The images incidentally identified a large focus of abnormal activity in the right pelvic region, which corresponded to the site of metastasis in the right ilium revealed on CT image.
Selective treatment of SCID mice bearing methotrexate-transport- resistant human acute lymphoblastic leukemia tumors with trimetrexate and leucovorin protection
Authors: JF Lacerda, E Goker, A Kheradpour, D Dennig, Y Elisseyeff, C Jagiello, RJ O'Reilly, JR Bertino
Journal: Blood (1995)
Abstract 6191: Efficacy and Safety Assessment of Anticoagulation Strategies in Peripheral Percutaneous Intervention
Authors: Imran Sheikh, S. Hinan Ahmed, Mubashir Ahmed, Athar Saeed, Jennifer Dochee, Atif Saeed, Imraan Ansaarie, Jayant Khitha, Mark W Mewissen, Ramagopal Tumuluri, Anjan Gupta, Suhail Allaqaband, Tanvir Bajwa
Journal: Circulation (2008)

Background: Anticoagulation strategies used in peripheral percutaneous intervention (PPI) are based primarily on percutaneous coronary intervention. In these studies, relatively higher doses of heparin were used, usually in combination with a GP IIb/IIIa agent. There are no studies comparing PPIs done with low-dose heparin alone versus bivalirudin in PPI. We compared the efficacy and safety (i.e. bleeding complications) of low-dose heparin versus bivalirudin in PPI. Methods: We assessed prospectively 160 consecutive patients who underwent PPI from January through April 2008 during their index hospitalization for bleeding and thrombotic complications. Inclusion criteria included patients age &gt;18 undergoing PPI for subclavian, renal or lower extremity arterial stenosis. Exclusion criteria included acute limb ischemia, use of fibrinolytic agents or GP IIb/IIIa antagonists, recent MI or CVA, and contraindication to heparin or bivalirudin. Out of 160 patients, 79 patients were dosed with heparin at 50 u/kg (goal ACT of 180 –225) and 81 patients were dosed with bivalirudin at 0.75 mcg/kg bolus followed by 1.75-mcg/kg infusion. Bivalirudin infusions were discontinued at the end of the procedure. Procedural success was defined as less than 30% post procedure residual stenosis. Major bleeding was defined as intracranial or retroperitoneal hemorrhage, or fall in Hgb ≥3 g/dl. All other bleeding was considered a minor bleed. In addition, anticoagulation cost analysis was conducted. Results: Procedural success in 100% and 96.2% patients (p=NS) (no patient suffered acute vessel occlusion or any intraprocedural thrombotic complications), major bleeding occurred in 0% and 3.7% patients (p=NS), minor bleeding occurred in 5.1% and 11% patients (p=NS), who received heparin and bivalirudin, respectively. There was no statistical difference in time to sheath removal, time-to-ambulation, and length of hospital stay. The average charge to patients for heparin was $66, whereas the charge for bivalirudin was $2727. Conclusion: Low-dose heparin is equally as safe and effective as bivalirudin in PPI. PPI with heparin is considerably more cost-effective than PPI with bivalirudin. Larger randomized studies are required to further evaluate this issue.
Abstract 3231: Esophageal Capsule Endoscopy: Different Findings Based On The Anesthesia Protocol
Authors: Luigi Di Biase, Stacy Poe, Luis Carlos Saenz, Miguel Vacca, Mauricio Cabrales, Dimpi Patel, Luciana Armaganijan, Chia-Tung Wu, Sonnie Kai, Lucie Riedlbauchova, Moataz El hallage, Claude S. Elayi, Chi Keong Ching, Conor Barrett, John Meulet, Karen Phillips, Sandeep Duggal, Oussama M. Wazni, Mohamed Kanj, Robert A. Schweikert, Jennifer E. Cummings, J. David Burkhardt, Walid I. Saliba, Mauricio Arruda, Andrea Natale
Journal: Circulation (2007)

Introduction: Left atrioesophageal fistula is a rare but devastating complication that can occur following catheter ablation of atrial fibrillation. Methods : Fifty patients undergoing AF ablation for paroxysmal and persistent/permanent symptomatic atrial fibrillation refractory to AAD have been enrolled and randomized into 2 groups: those undergoing the procedure under conscious sedation with fentanil or midazolam (25 patients, group and those receiving general anesthesia (25 patients, group All patients underwent esophageal temperature monitoring during the procedure. Radiofrequency energy was discontinued when the luminal temperature reached 39 C. After ablation all patients had capsule endoscopy to assess the presence for endoluminal tissue damage of the esophagus. Results : The results are shown in the table below Conclusion : The use of general anesthesia increases the risk of positive esophageal findings by capsule endoscopy
Abstract 13629: MicroRNAs May Control MRNA Networks in Circulating PBMCs During the Acute Phase of Kawasaki Disease
Authors: Kazuyoshi Saito, Ichiro Takasaki, Keiichi Hirono, Keijiro Ibuki, Kazuhiro Watanabe, Neil E Bowles, Fukiko Ichida, Toshio Miyawaki
Journal: Circulation (2010)

Background: MicroRNAs (miRs) are small noncoding RNAs of 18-25 nucleotides that mediate gene silencing through imperfect hybridization to 3’ untranslated regions (3’UTR) in target mRNAs. MiRs modul...
Abstract 18109: Primary Angioplasty in Nonagenarian Patients. Results From a Spanish Multicenter Registry
Authors: Pablo Salinas, Raul Moreno, Guillermo Galeote, Luis Calvo, Santiago Jimenez-Valero, Angel Sanchez-Recalde, Roberto Martin-Reyes, Ignacio Plaza, Jose Lopez-Sendon
Journal: Circulation (2010)

Introduction: In spite of the increasing number of very elderly patients admitted with STEMI there are very few published data about nonagenarian patients treated with primary angioplasty (PA). Methods: we conducted a multicenter registry focused on nonagenarian (≥ 90 years old) patients treated with PCI, gathering data from 5 tertiary centers in Spain. We selected those patients admitted with STEMI who presented within 12 hours after symptoms onset and who were treated with PA. Results: A total of 36 patients were included. Mean age was 91.5 (range 90–98). Baseline characteristics: 56% women, 39% hypertension, 14% dyslipidemia, 14% diabetes, 11% smokers, 8% prior myocardial infarction, 8% prior revascularization, mean LVEF 43.5±11%. At admission, 83% were in Killip class 1 or 2, and 11% in shock. Coronary multivessel disease was found in 57% of the patients, but the mean number of vessels treated per patient was 1.1±0.5 vessels, showing a strategy of treating the culprit vessel only. An average of 1.3±0....
Abstract 9832: Individualized Patient Education Program for Prevention of Venous Thromboembolism in Hospitalized Medical Patients
Authors: Gregory Piazza, Thanh N Nguyen, Ruth Morrison, Deborah Cios, Benjamin Hohlfelder, John Fanikos, Samuel Z Goldhaber
Journal: Circulation (2011)

Introduction: Up to 15% of clinician-ordered doses of injectable prophylactic unfractionated or low-molecular weight heparin to prevent venous thromboembolism (VTE) are not administered. Patient refusal accounts for nearly 50% of these omitted doses. Hypothesis: We hypothesized that a pharmacist-led individualized patient education program will improve medication adherence to clinician-ordered doses of injectable prophylactic anticoagulation. Methods: Using our hospital's Electronic Health Record, we identified 528 hospitalized medical patients who were ordered for injectable pharmacological VTE prophylaxis. We evaluated the impact of pharmacist-led individualized patient education sessions, conducted within 24 hours of the initial order for prophylactic anticoagulation, on medication adherence (defined as the ratio of doses administered to doses scheduled). Results: Unfractionated heparin was the most frequent clinician-ordered injectable prophylactic anticoagulant (55%) followed by dalteparin (45%). Individualized patient education sessions were conducted within 24 hours of the first dose of prophylactic anticoagulation in 99% of patients. The patient education program improved adherence to clinician-ordered pharmacological VTE prophylaxis from 89.9% in our historical cohort to 94.4% (p&lt;0.0001). The proportion of patients receiving 100% of scheduled doses of pharmacological prophylaxis increased from 82.8% to 91.9% (p=0.001). Patient refusal as a reason for omitted doses decreased from 43.7% to 29.3% after the patient education program (p=0.001). Conclusion: Pharmacist-led individualized patient education sessions improved medication adherence to clinician-ordered pharmacological VTE prophylaxis and reduced patient refusal as a cause of omitted doses. Efforts to enhance VTE prevention among hospitalized medical patients should focus on patient education to improve adherence to pharmacological VTE prophylaxis.
CONSORT statement on the reporting standards of clinical trials
Authors: T W Meade, N. Wald, R. Collins, H. J Bromhead, N. W Goodman, L. B O'Toole, D. G Altman, D. Moher, D. Rennie
Journal: BMJ (1997)

Recommendations are inappropriate for trial reports Editor—In his editorial on the CONSORT statement Douglas G Altman states that since “only randomised trials have the potential directly to affect patient care ... it is ... reasonable to require higher standards for papers reporting randomised trials than those describing other types of study.” 1 But although randomised trials are usually the preferred approach for the unbiased evalua› tion of treatments, non›randomised obser› vational studies also influence treatment. Because the correct interpretation of obser› vational studies is much more difficult, largely due to uncontrollable biases, their description and analysis call for at least as much care as do randomised trials. Some› times, of course, randomised comparisons are unnecessary—for example, to determine the value of AE fetoprotein screening for neural tube defects. CONSORT is the product of delibera› tions conducted almost entirely through North American journals.
Effect of Amlodipine on the Survival of Patients With Severe Chronic Heart Failure Due to a Nonischemic Cardiomyopathy
Authors: Milton Packer, Peter Carson, Uri Elkayam, Marvin A. Konstam, Gordon Moe, Christopher O'Connor, Jean-Lucien Rouleau, Douglas Schocken, Susan A. Anderson, David L. DeMets
Journal: JACC Heart Failure (2013)
Abstract P38: Just-In-Time Simulation Training Improves ICU Physician Trainee Airway Resuscitation Participation without Compromising Procedural Success or Safety
Authors: Akira Nishisaki, Shawn Colborn, Christine Watson, Dana Niles, Susan Ferry, Sujatha Devale, Ram Bishnoi, Aaron Donoghue, Andrew Meyer, Mark Helfaer, Ron Walls, Vinay Nadkarni
Journal: Circulation (2008)

Introduction : Competence in orotracheal intubation is a requirement for Pediatric residency. However, opportunities for residents are limited. We hypothesize Just-in-Time simulation-based multi-disciplinary team training for acute airway resuscitation in a pediatric ICU (PICU) would improve physician trainee intubation participation and success, and decrease undesired T racheal I ntubation A ssociated E vents ( TIAE ) such as esophageal intubation, or mainstem intubation. Methods : With IRB approval, on-call residents in a tertiary PICU received 30 minute airway resuscitation multidisciplinary simulation training before 24 hour on-call duties. Airway resuscitation performance was captured in both simulated and real airway resuscitations using a validated airway registry (NEAR-4-KIDS) tool. Resident participation, success, first attempt success, and the incidence of TIAE were compared before and after this intervention (Pre: Jan 2005–Jun11, 2007; Post: Jun12, 2007–May2008). Analysis by time series analysis, and Fisher’s exact test. Results : 150 simulation training sessions were conducted, and 123 consecutive real orotracheal intubations were evaluated. Resident participation significantly increased: Pre 23 % vs Post 36 % (p=0.016). Overall resident airway resuscitation success (58% vs. 68%, p=0.39) and first attempt success (44% vs. 56%, p= 0.30) improvement were not statistically significant. Despite the increased participation by resident trainees, there was no increase in TIAE (23% vs. 21%, p=0.78) in real airway resuscitation. Conclusion : Simulation-based “Just-in-Time” multidisciplinary training for pediatric advanced airway resuscitation improved actual resident trainee participation in real ICU intubations, but did not compromise airway resuscitation procedural success or patient safety. Supported by Agency for Healthcare Research and Quality (AHRQ), and CHOP Endowed Chair, Critical Care Medicine
Abstract 20873: A Multipotent Cardiovascular Progenitor Population Identified by the SRF Cardiac-Specific Enhancer is Detected Prior to Mesoderm Formation
Authors: Matthew R Barron, Matthew George, Michelina Lacovino, Jayne M Squirrell, Pratik A Lalit, Brett Tortelli, Michael Kyba, Gary E Lyons, Timothy J Kamp
Journal: Circulation (2010)

Cardiac progenitors hold appeal for repair of diseased hearts because they are highly proliferative and can potentially generate all major cell types in the adult heart. Serum response factor (SRF) is a transcription factor expressed prior to appearance of mesoderm and is necessary for gastrulation. Although SRF is expressed in multiple tissues, we identified an enhancer sequence that confines expression to the cardiac lineage. To test the hypothesis that this SRF cardiac enhancer can be used to isolate multi-potent cardiac progenitors (SRF GFP  cells), we generated SRF GFP  cells using a construct consisting of the SRF promoter and cardiac enhancer flanking eGFP. This was targeted to the HRPT locus in mouse ES cells using an inducible cassette exchange strategy with Cre recombinase. Positive SRF GFP  clones, confirmed by RT-PCR, were differentiated in embryoid bodies (EBs) to monitor GFP expression. GFP expression was first observed at 8 hours. RT-qPCR confirmed that GFP+ cells from day 1 EBs express SRF but not early mesoderm markers brachyury (T) or Mesp1, indicating that these cells are detectable prior to mesoderm formation. Importantly, SRF GFP  cells do not express pluripotency markers Oct4 or Nanog, thus are not residual ES cells. Multiphoton microscopy demonstrated that SRF GFP  cells proliferate in permissive areas of live EBs, forming localized clusters by day 4 and ultimately GFP+ contracting regions. Flow cytometry analysis of day 2–5 EBs revealed that 3–6% of cells express GFP. Isolated day 2 SRF GFP  cells have the capacity to differentiate  in vitro  into cell types found within the adult heart, including cardiac myocytes (anti-cTnT), endothelial cells (anti-CD31), fibroblasts (anti-fibroblast) and smooth muscle cells (anti-sm-MHC). SRF GFP  cells isolated from day 4 EBs express markers of cardiac precursors, including Nkx2.5, Flk1, Isl1, T and Tbx18. SRF GFP  cells, when serially passaged, maintain expression of cardiac progenitor proteins and differentiation capacity, introducing the possibility of expansion pre-transplantation. These results demonstrate a reporter system to identify and isolate cardiac progenitors specified prior to mesoderm formation, and this early population of progenitors holds unique promise for cardiac repair.
Prolonged Remission After TPO-Receptor Agonist Discontinuation In Adults With Chronic ITP. Results Of a French Observational Study
Authors: Matthieu Mahévas, Olivier Fain, Mikael Ebbo, Medhi Khellaf, Nicolas Limal, Nicolas Schleinitz, Corinne Haioun, Philippe Bierling, Bertrand Godeau, Marc Michel
Journal: Blood (2013)
Abstract 19: Targeted Education Can Change Paramedics' Attitudes to CPR
Authors: Andres Neset, Eric Beairsto, Edgar Goulette, Susan Dugas, Mathieu Hachée, Jo Kramer-Johansen
Journal: Circulation (2011)

Objectives: One reason for sub-standard CPR quality may be linked to long-held beliefs and lack of knowledge. We wanted to study if targeted education could change these attitudes among paramedics. Methods: Ambulance New Brunswick introduced a continuous quality improvement system (CQI) for out-of-hospital cardiac arrest in 2008 based on CPR-performance recordings. Shortly after this, all paramedics were invited to answer a survey, to study the attitudes and knowledge towards CPR. Learning objectives were constructed from the survey to address attitudes and lack of knowledge, and were used in the following training sessions. The survey was repeated in 2011 to evaluate the effect training had on attitudes. Respondents graded statements on a five-point Likert scale from strongly agree to strongly disagree. Chi-square tests with continuity correction (SPSS v16) were used to test for changes in proportions between the combined agree and disagree answers. Results: Of 761 invited paramedics, 288 answered in 2008; in 2011 233 of 967 answered. Learning objectives on three subjects were identified: importance of compression depth, confidence in the importance of pre-hospital cardiac arrest care and acceptance of CQI system. A positive change was seen for all three learning objectives, see table 1. Conclusion: It is possible to change long-held beliefs and attitudes towards CPR trough targeted education.
Abstract 4890: Myocardial Fibrosis and Diastolic Dysfunction Following Calcium-Channel Blockers or Angiotensin II Receptor Blockers in Hypertensive Patients
Authors: Chikako Yoshida, Takeshi Tsujino, Akiko Goda, Mika Matsumoto, Yoshiro Naito, Shinji Nakao, Akira Ezumi, Masaaki Lee-Kawabata, Tohru Masuyama
Journal: Circulation (2008)

Objectives : Myocardial fibrosis develops in the hypertensive heart, and brings about LV diastolic dysfunction. Myocardial fibrosis is regulated by collagen production and degradation. Collagen degradation is regulated by matrix metalloproteinases (MMPs), a family of zinc-dependent interstitial enzymes, and their tissue inhibitors (TIMPs). We investigated how long-term administration of calcium-channel blockers (CCB) or Angiotensin II receptor blockers (ARB) affects collagen production/degradation and LV diastolic dysfunction. Methods : Study population consisted of 44 untreated hypertensive patients (31 females, 13 males, mean age:57±11 years). They were randomly assigned to one of the 2 groups: CCB group in which Amlodipine of 5–10mg was given daily (n=22) and ARB group in which Losartan of 50–100mg was given daily (n=22). LV mass index (LVMI) and tissue Doppler early diastolic mitral annular velocity (E′) were echocardiographically assessed before and 6 and 12 months after treatment. Procollagen type I C-terminal propeptide (PICP) was determined with enzyme immunoassay as a serum marker of collagen production, while MMP-2 and TIMP-1 were determined with ELISA as makers of collagen degradation. Results (table ): E′ increased in the ARB group but not in the CCB group while reductions in blood pressure (BP) and LVMI were comparable between the group. PICP did not change after treatment in either group, but MMP-2 increased only in the ARB group. TIMP-1 did not change in either group. Conclusions : In spite of similar reduction of SBP and LVMI, ARB provided larger benefits on LV diastolic function than CCB. Collagen production was constant in both groups, but ARB facilitated more collagen degradation than CCB, and the difference should have contributed to the impact on LV diastolic function.
Characteristics of psychoanalytic patients under a nationalized health plan: DSM-III-R diagnoses, previous treatment, and childhood trauma
Authors: N Doidge, B Simon, L A Gillies, R Ruskin
Journal: American Journal of Psychiatry (1994)

This article reports the results of a survey to collect data on the characteristics of patients in psychoanalysis under a nationalized health insurance scheme.A questionnaire, to be answered anonymously, was sent to all 174 accredited psychoanalysts in Ontario, Canada. Part 1 of the questionnaire consisted of 38 questions on the analyst's pattern of practice. Part 2, also to be filled out by the analyst, consisted of 452 questions on the demographic characteristics, childhood traumas, DSM-III-R diagnoses, and indications for psychoanalysis of each of the analyst's patients.One hundred seventeen analysts responded--a survey response rate of 67%--with data on 580 patients. Fifty-nine percent (N = 344) of patients were women, and 41% (N = 236) were men. Eighty-two percent had attempted other forms of treatment, including briefer forms of psychotherapy and medication, prior to psychoanalysis. During childhood, 23% had had traumatic separations, 23% had been sexually abused, 22% had been physically abused, and 21% had had a parent or sibling die. The mean number of adult psychiatric disorders at the beginning of analysis was four, and the mode was two.In a nationalized health insurance scheme, the psychoanalytic patients were mostly women, they had high rates of trauma and psychopathology, and they had attempted other forms of briefer treatment before resorting to psychoanalysis.
Abstract 1037: Plasminogen Activator Inhibitor-1 Protects Coronary Vessel Wall and Prevents Cardiac Fibrosis in PAI-1 / , ApoE / Mice
Authors: Takeaki Kaneko, Mesut Eren, Douglas Vaughan
Journal: Circulation (2007)

Introduction:  Plasminogen activator inhibitor (PAI)-1, the physiologic inhibitor of fibrinolysis, preserves extracellular matrix scaffold permissive for cell migration and induces proliferation in vascular wall. On the other hand, several studies implicate elevated plasminogen activity causes cardiac fibrosis. However it is unclear whether deficiency of PAI-1 in vascular wall or macrophages can also initiate vascular remodeling and cardiac fibrosis. We assessed the hypothesis that deficiency of PAI-1 causes cardiac fibrosis in double knockout (DKO) (PAI-1−/−, ApoE−/−) mice.   Methods:  We administered saline as control and angiotensin II (Ang II) (600ng/kg/min) to DKO mice by using osmotic pump for 2 weeks. After 8 weeks we harvested the hearts for histology. To determine the effect of PAI-1 in the vessel wall, we administered same dose Ang II to PAI-1 heterozygote (PAI-1+/−, ApoE−/−) mice and PAI-1 KO mice. To determine the effect of macrophages in development of cardiac fibrosis, we used DKO mice and ApoE KO mice as recipients. And we transplanted bone marrow from DKO, ApoE KO, PAI-1 KO and Wild type mice to DKO and ApoE KO mice after lethal irradiation. Then we administered same dose Ang II for 2 weeks and after 8 weeks we harvested the hearts.   Results:  Ang II caused remarkable cardiac fibrosis (subepicardial fibrosis and myocardial fibrosis) in DKO mice (DKO + Ang II: 60%, n=10) and DKO mice receiving DKO BM (DKO (DKOBM) + Ang II: 77.8%, n=9). Cardiac fibrosis was not almost observed in DKO mice given saline. (DKO + Saline: 7.7%, n=13) Ang II didn’t cause cardiac fibrosis in ApoE KO mice and PAI-1 heterozygote mice (PAI-1 Hetero mice: 0%, n=10). 30% of PAI-1 KO mice administered Ang II caused cardiac fibrosis (PAI-1 KO mice: 30%, n=10). The ratio of cardiac fibrosis in DKO mice receiving ApoE KO BM, PAI-1 KO BM and WT BM were significantly reduced. (ApoE KO BM: 44.4%, n=9), (PAI-1 KO BM: 30.0%, n=10), (WT BM: 14.2%, n=7)   Conclusions:  Ang II causes cardiac fibrosis in DKO mice. PAI-1 in the vascular wall completely protects cardiac fibrosis. PAI-1 and ApoE secretion from macrophages partially protects cardiac fibrosis. PAI-1 protects degradation of laminin and prevents structural disorganization of capillary basement membranes in DKO Mice.
Abstract 13671: The Presence of Supraventricular Premature Complexes is Associated with Increased Risks for Atrial Fibrillation Incidence and Death in Community-Based Health Checkups: The Ibaraki Prefectural Health Study
Authors: Nobuyuki Murakoshi, DongZhu Xu, Toshimi Sairenchi, Miyako Igarashi, Fujiko Irie, Takuji Tomizawa, Kazumasa Yamagishi, Hiroyasu Iso, Iwao Yamaguchi, Junko Gunji, Hitoshi Ota, Kazutaka Aonuma
Journal: Circulation (2012)

Introduction: Supraventricular premature complex (SVPC) is considered as benign arrhythmias, while SVPC is an independent electrocardiographic predictor for new onset of atrial fibrillation (AF). T...