tbuckley/cabot-search huggingface dataset:
Antibody Status, Disease History, and Incidence of SARS-CoV-2 Infection Among Patients on Chronic Dialysis
Authors: Dena E. Cohen, Scott Sibbel, Gilbert Marlowe, Kelsey Bludorn, Dawn Miller, Tara Kelley, Jeffrey Connaire, Amy Young, Francesca Tentori, Steven M. Brunelli
Journal: Journal of the American Society of Nephrology (2021)

Significance Statement Among the general population, infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) robustly protects against subsequent reinfection. Whether this finding extends to patients with ESKD was not previously known. Here, we prospectively studied patients treated with hemodialysis in the United States, and compared SARS-CoV-2 infection rates among patients with and without evidence of prior SARS-CoV-2 infection (either baseline antibodies or history of disease). We found that although prior SARS-CoV-2 infection protected against subsequent reinfection, the effect was not as strong as in the general population. This study indicates that prior infection with SARS-CoV-2 provides incomplete protection in patients with ESKD, and argues in favor of prioritizing such patients for vaccination regardless of prior infection status. Background Although reinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is rare among individuals with few coronavirus disease 2019 (COVID-19) risk factors, the ability of naturally acquired immunity to prevent reinfection among patients with ESKD is not known. Methods This prospective study was conducted among adults with ESKD treated with in-center hemodialysis (ICHD) in the United States. Exposure was ascribed on the basis of the presence or absence of IgG against SARS-CoV-2 at baseline, and separately, a history of documented COVID-19 before study entry. Outcomes were assessed after an infection-free period, and were any SARS-CoV-2 infection ( i.e., detected by protocolized PCR tests or during routine clinical surveillance), and clinically manifest COVID-19 (consisting of only the latter). Results Of 2337 consented participants who met study inclusion criteria, 9.5% were anti–SARS-CoV-2 IgG positive at baseline; 3.6% had a history of COVID-19. Over 6679 patient-months of follow-up, 263 participants had evidence of any SARS-CoV-2 infection, including 141 who had clinically manifest COVID-19. Presence of anti–SARS-CoV-2 IgG (versus its absence) at baseline was associated with lower risk of any SARS-CoV-2 infection (incidence rate ratio, 0.55; 95% confidence interval, 0.32 to 0.95) and clinically manifest COVID-19 0.21 (95% confidence interval, 0.07 to 0.67). Conclusion Among patients with ESKD, naturally acquired anti–SARS-CoV-2 IgG positivity is associated with a 45% lower risk of subsequent SARS-CoV-2 infection, and a 79% lower risk of clinically manifest COVID-19. Because natural immunity is incomplete, patients with ESKD should be prioritized for SARS-CoV-2 vaccination, independent of their COVID-19 disease history.
Persistence of the Minimal Residual Disease at the End of Induction Is Not a Factor of Poor Prognosis If Imatinib Was Changed to the Dasatinib By Ph+ RALL Protocol in Ph-Positive Acute Lymphoblastic Leukemia Patients
Authors: Olga A. Gavrilina, Elena N. Parovichnikova, Vera V. Troitskaya, Larisa A. Kuzmina, Sergey N. Bondarenko, Valery Lapin, Tatiana N. Obukhova, Andrey Sudarikov, Valery G. Savchenko
Journal: Blood (2017)
WT-1の新規ペプチドのマッピングおよびWT-1 + 白血病に対する細胞毒性作用を有するエピトープ特異的HLA制限T細胞を誘発するHLAアレルの呈示
Authors: Doubrovina Ekaterina, Carpenter Taissia, Pankov Dmitry, Selvakumar Annamalai, Hasan Aisha, J O’Reilly Richard
Journal: Blood (2012)
Abstract 13074: Hypoxia-Driven Long Noncoding RNA KMT2E-AS1 Modulates Histone Methylation to Control Endothelial Metabolic Reprogramming and Pulmonary Hypertension
Authors: Qiujun Yu, Yi Yin Tai, Ying Tang, Jingsi Zhao, Vinny Negi, Adam L Handen, Catherine G Corey, Frances R Belmonte, Brian Schwartz, Balkrishen Bhat, B. Nelson Chau, Gil Speyer, Bing Wang, Sruti Shiva, Brett A Kaufman, Seungchan Kim, Thomas Bertero, Stephen Y Chan
Journal: Circulation (2019)

Background: Pulmonary hypertension (PH) is a deadly vascular disease with poorly defined molecular origins. While evidence is emerging in regard to dysregulation of long non-coding RNAs (lncRNAs) i...
Abstract LB077: Adrenergic signaling induces neuroendocrine differentiation of prostate adenocarcinoma cells
Authors: Anand Krishnan, Shubham Dwivedi, Maricris Bautista, Tauqeer Iftikhar
Journal: Cancer Research (2021)

Abstract Prostate cancer is the leading cancer diagnosed among men worldwide. The prostate cancer-associated mortality is due to the development of aggressive neuroendocrine prostate cancer (NEPC). Unfortunately, there is no effective treatment available for NEPC at present. This is due to the lack of proper understanding of the molecular switch that triggers neuroendocrine changes in prostate adenocarcinoma cells. Recent research demonstrated that peripheral nerves promote prostate cancer progression and metastasis. However, there is no clear understanding of the involvement of sympathetic nerves or their signaling in facilitating NEPC. In this work, we examined the effect of the sympathetic neurotransmitter norepinephrine (NE) in inducing neuroendocrine differentiation (NED) of prostate cancer cells in vitro. We used androgen-sensitive LNCaP and androgen-insensitive DU145 cells for the study. We examined the dose and time-dependent effect of NE in inducing NED-related phenotypic alterations in these cells using bright field and fluorescence imaging. NED-related molecular alterations were assessed using real-time PCR, western bot and immunocytochemistry. We found that NE induces characteristic NEPC morphological changes, such as compact cell bodies and neurite-like extensions, in both DU145 and LNCaP cells. At the mRNA level, NE induced the expression of the NED markers chromogranin B, synaptophysin and βIII tubulin in both cell types. Further immunoblot and immunostaining showed the upregulation of chromogranin B in these cells. We repeated the experiments in growth factor deprived conditions by avoiding fetal bovine serum in the cultures to mimic growth deprivation to prostate cancer cells, which they experience during androgen deprivation therapy. Surprisingly, the NE induced NED changes were more pronounced in the growth factor deprived conditions. Overall, our result indicates the potential of NE in inducing NED in prostate cancer cells and point towards a critical role for this sympathetic neurotransmitter in facilitating the development of NEPC. Citation Format: Anand Krishnan, Shubham Dwivedi, Maricris Bautista, Tauqeer Iftikhar. Adrenergic signaling induces neuroendocrine differentiation of prostate adenocarcinoma cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr LB077.
Hancock resigns after covid guideline breach and Sajid Javid becomes new health secretary
Authors: Gareth Iacobucci
Journal: BMJ (2021)

Matt Hancock resigned as England’s health secretary on Saturday evening after he was caught breaking his own covid-19 rules on social distancing by kissing an aide in his ministerial office.

Former chancellor Sajid Javid has been reappointed to the cabinet as the new secretary of state for health and social care after Hancock’s resignation.

Hancock had admitted breaking social distancing guidelines after the Sun newspaper published pictures of him kissing Gina Coladangelo, a long time friend of his and a non-executive director of the health department.1

But while the prime minister defended Hancock and said on Friday 25 June that he considered the matter …
Short-course 177Lu-PSMA-617 Radioligand Therapy in High-volume Metastatic Hormone-sensitive Prostate Cancer: Time to Take the Leap?
Authors: Swayamjeet Satapathy, Namrata Das, Ashwani Sood, Shrawan Kumar Singh, Shikha Goyal, Renu Madan, Bhagwant R Mittal
Journal: European Urology (2021)
Applying Neural Networking Identifies Antiphospholipid Syndrome Patients with an Accuracy of 98.7
Authors: Romy Kremers, Stéphane Zuily, Hilde Kelchtermans, Philip G. de Groot, Tessa Peters, Saartje Bloemen, Coenraad Hemker, Denis Wahl, Bas De Laat
Journal: Blood (2017)
Optical Frequency Domain Imaging Guidance for Coronary Stent Implantation in Comparison with Intra Ultrasound Guidance
Authors: Kobayashi Tomoko, Sasaki Satoru, Takahashi Hideaki, Otagaki Munemitsu, Hano Yoshifumi, Mizobuchi Masahiro, Funatsu Atsushi, Nakamura Shigeru
Journal: Circulation (2014)
Test–Retest Reliability and Consistency of HVPG and Impact on Trial Design
Authors: Wayne Bai, Mustafa Al‐Karaghouli, Jesse Stach, Shuen Sung, Granville J. Matheson, Juan G. Abraldes
Journal: Hepatology (2021)

Portal hypertension (PH) is a major driver for cirrhosis complications. Portal pressure is estimated in practice by the HVPG. The assessment of HVPG changes has been used for drug development in PH. This study aimed at quantifying the test-retest reliability and consistency of HVPG in the specific context of randomized controlled trials (RCTs) for the treatment of PH in cirrhosis and its impact on power calculations for trial design.We conducted a search of published RCTs in patients with cirrhosis reporting individual patient-level data of HVPG at baseline and after an intervention, which included a placebo or an untreated control arm. Baseline and follow-up HVPGs in the control groups were extracted after digitizing the plots. We assessed reliability and consistency and the potential impact of study characteristics. We retrieved a total of 289 before and after HVPG measurements in the placebo/untreated groups from 20 RCTs. The time span between the two HVPG measurements ranged between 20 minutes and 730 days. Pre-/post-HVPG variability was lower in studies including only compensated patients; therefore, modeled sample size calculations for trials in compensated cirrhosis were lower than for decompensated cirrhosis. A higher proportion of alcohol-associated cirrhosis and unicentric trials was associated with lower differences between baseline and follow-up measurements. The smallest detectable difference in an individual was 26% and 30% in compensated and decompensated patients, respectively.The test-retest reliability of HVPG is overall excellent. Within-individual variance was higher in studies including higher proportions of decompensated patients. These findings should be taken into account when performing power analysis for trials based on the effects on HVPG or when considering HVPG as a tool to guide therapy of PH.
Abstract 12693: P66Shc Signaling Pathway in the Heart Subjected to Ischemia/reperfusion Injury
Authors: Huamei He, Hui Xiong, Francis X McGowan
Journal: Circulation (2019)

Introduction: p66Shc, a splice variant of the ShcA adaptor protein family, is an important regulator of mitochondrial reactive oxygen species (ROS) generation in the cells subjected to oxidant inju...
Mussel-inspired adhesive antioxidant antibacterial hemostatic composite hydrogel wound dressing via photo-polymerization for infected skin wound healing
Authors: Yutong Yang, Yongping Liang, Jueying Chen, Xianglong Duan, Baolin Guo
Journal: Bioactive Materials (2021)

With the increasing prevalence of drug-resistant bacterial infections and the slow healing of chronically infected wounds, the development of new antibacterial and accelerated wound healing dressings has become a serious challenge. In order to solve this problem, we developed photo-crosslinked multifunctional antibacterial adhesive anti-oxidant hemostatic hydrogel dressings based on polyethylene glycol monomethyl ether modified glycidyl methacrylate functionalized chitosan (CSG-PEG), methacrylamide dopamine (DMA) and zinc ion for disinfection of drug-resistant bacteria and promoting wound healing. The mechanical properties, rheological properties and morphology of hydrogels were characterized, and the biocompatibility of these hydrogels was studied through cell compatibility and blood compatibility tests. These hydrogels were tested for the in vitro blood-clotting ability of whole blood and showed good hemostatic ability in the mouse liver hemorrhage model and the mouse-tail amputation model. In addition, it has been confirmed that the multifunctional hydrogels have good inherent antibacterial properties against Methicillin-resistant Staphylococcus aureus (MRSA). In the full-thickness skin defect model infected with MRSA, the wound closure ratio, thickness of granulation tissue, number of collagen deposition, regeneration of blood vessels and hair follicles were measured. The inflammation-related cytokines (CD68) and angiogenesis-related cytokines (CD31) expressed during skin regeneration were studied. All results indicate that these multifunctional antibacterial adhesive hemostatic hydrogels have better healing effects than commercially available Tegaderm™ Film, revealing that they have become promising alternative in the healing of infected wounds.
Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy
Authors: Marie Siwicki, Nicolas A. Gort-Freitas, Marius Messemaker, Ruben Bill, Jeremy Gungabeesoon, Camilla Engblom, Rapolas Zilionis, Christopher Garris, Genevieve M. Gerhard, Anna Kohl, Yunkang Lin, Angela E. Zou, Chiara Cianciaruso, Evangelia Bolli, Christina Pfirschke, Yi-Jang Lin, Cecile Piot, John E. Mindur, Nilesh Talele, Rainer H. Kohler, Yoshiko Iwamoto, Mari Mino-Kenudson, Sara I. Pai, Claudio deVito, Thibaud Koessler, Doron Merkler, Alexander Coukos, Alexandre Wicky, Montserrat Fraga, Christine Sempoux, Rakesh K. Jain, Pierre-Yves Dietrich, Olivier Michielin, Ralph Weissleder, Allon M. Klein, Mikael J. Pittet
Journal: Science Immunology (2021)

Resident macrophages and recruited neutrophils cause toxicities in tumor-free tissues after immunotherapy.
NAFLD and Alcohol‐Associated Liver Disease Will Be Responsible for Almost All New Diagnoses of Cirrhosis in Canada by 2040
Authors: Jennifer A. Flemming, Maya Djerboua, Patti A. Groome, Christopher M. Booth, Norah A. Terrault
Journal: Hepatology (2021)

Background and Aims Mortality secondary to cirrhosis in North America is increasing. We describe the incidence of cirrhosis stratified by birth cohort and cirrhosis etiology and project disease burden to 2040. Approach and Results This is a retrospective cohort study in Ontario, Canada, using population-based administrative health care data. Individuals with incident cirrhosis (2000-2017) were identified, and etiology was defined as HCV, HBV, NAFLD, alcohol-associated liver disease (ALD), or autoimmune liver disease/other using validated case definitions. Annual age/sex-adjusted cirrhosis incidence rate per 100,000 person-years was calculated with incidence projection to 2040 using age-period-cohort modeling along with average annual percent change (AAPC) in cirrhosis incidence stratified by birth cohort and etiology. In total, 159,549 incident cases of cirrhosis were identified. Incidence increased by 26% with an AAPC of 2%/year (95% CI, 1.6-2.4; P < 0.001). The largest increases were for HCV (AAPC, 4.1%/year; 95% CI, 2.6-5.7; P < 0.001) and NAFLD (AAPC, 3.3%/year; 95% CI, 2.6-4.1%; P < 0.001). ALD and HCV cirrhosis in those born >1980 increased by 11.6%/year (95% CI, 9.3-13.9; P < 0.001) and 9.5%/year (95% CI, 6.2-13.0; P < 0.001), respectively. However, by 2040, cirrhosis incidence is projected to continue to increase, driven mostly by NAFLD, especially in postmenopausal women, and ALD in individuals born >1980. Conclusions Cirrhosis incidence will continue to increase over the next two decades secondary to NAFLD with a worrisome rapid rise in ALD cirrhosis among young adults. Public education, policy, and intervention targeting NAFLD risk factors and alcohol use in young adults are urgently needed.
Intratumor CMS Heterogeneity Impacts Patient Prognosis in Localized Colon Cancer
Authors: Laetitia Marisa, Yuna Blum, Julien Taieb, Mira Ayadi, Camilla Pilati, Karine Le Malicot, Côme Lepage, Ramon Salazar, Daniela Aust, Alex Duval, Hélène Blons, Valérie Taly, David Gentien, Audrey Rapinat, Janick Selves, Sophie Mouillet-Richard, Valérie Boige, Jean-François Emile, Aurélien de Reyniès, Pierre Laurent-Puig
Journal: Clinical Cancer Research (2021)

Abstract Purpose: The consensus molecular subtypes (CMS) represent a significant advance in the understanding of intertumor heterogeneity in colon cancer. Intratumor heterogeneity (ITH) is the new frontier for refining prognostication and understanding treatment resistance. This study aims at deciphering the transcriptomic ITH of colon cancer and understanding its potential prognostic implications. Experimental Design: We deconvoluted the transcriptomic profiles of 1,779 tumors from the PETACC8 trial and 155 colon cancer cell lines as weighted sums of the four CMSs, using the Weighted In Silico Pathology (WISP) algorithm. We assigned to each tumor and cell line a combination of up to three CMS subtypes with a threshold above 20%. Results: Over 55% of tumors corresponded to mixtures of at least two CMSs, demonstrating pervasive ITH in colon cancer. Of note, ITH was associated with shorter disease-free survival (DFS) and overall survival, [HR, 1.34; 95% confidence interval (CI; 1.12–1.59), 1.40, 95% CI (1.14–1.71), respectively]. Moreover, we uncovered specific combinations of CMS associated with dismal prognosis. In multivariate analysis, ITH represents the third parameter explaining DFS variance, after T and N stages. At a cellular level, combined WISP and single-cell transcriptomic analysis revealed that most colon cancer cell lines are a mixture of cells falling into different CMSs, indicating that ITH may correspond to distinct functional statuses of colon cancer cells. Conclusions: This study shows that CMS-based transcriptomic ITH is frequent in colon cancer and impacts its prognosis. CMS-based transcriptomic ITH may correspond to distinct functional statuses of colon cancer cells, suggesting plasticity between CMS-related cell populations. Transcriptomic ITH deserves further assessment in the context of personalized medicine.
Parenthood Rates and Use of Assisted Reproductive Techniques in Younger Hodgkin Lymphoma Survivors: A Danish Population-Based Study
Authors: Andreas K. Øvlisen, Lasse H. Jakobsen, Sandra Eloranta, Kristian H. Kragholm, Martin Hutchings, Henrik Frederiksen, Peter Kamper, Rasmus Bo Dahl-Sørensen, Danny Stoltenberg, Caroline E. Weibull, Joshua P. Entrop, Ingrid Glimelius, Karin E. Smedby, Christian Torp-Pedersen, Marianne T. Severinsen, Tarec C. El-Galaly
Journal: Journal of Clinical Oncology (2021)

The majority of young adults with Hodgkin lymphoma (HL) are cured, but chemotherapy-induced infertility can have profound psychosocial consequences. Providing data on parenthood rates and use of assisted reproductive techniques (ARTs) after contemporary HL treatment is important for patient counseling and survivorship care.All Danish patients with HL diagnosed during 2000-2015 at the ages 18-40 years who achieved remission after first-line therapy were included and matched on age, sex, and parenthood status to five random persons from the general population. Parenthood rates were defined as the rate of first live birth per 1,000 person years, starting 9 months after HL diagnosis. Nationwide birth and patient registers were used to capture parenthood outcomes and ARTs use.A total of 793 HL survivors and 3,965 comparators were included (median follow-up 8.7 years). Similar parenthood rates were observed for male and female HL survivors when compared with matched comparators (56.2 v 57.1; P = .871 for males and 63.8 v 61.2; P = .672 for females). For male HL survivors, BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone) therapy was associated with lower parenthood rates as compared to the matched comparators (28.1 v 60.8; P = .020). Live birth after ARTs were more common for HL survivors than for comparators (males 21.6% v 6.3%; P < .001; females 13.6% v 5.5%; P = .001). There were no differences in gestational age, Apgar score, or newborn measurements between HL survivors and matched comparators.The parenthood rates for HL survivors who have not experienced relapse were generally similar to the general population. However, ARTs were used more often before the first live birth in HL survivors, which is relevant information when discussing possible long-term side effects and fertility-preserving treatment options.
Association between Airport-Related Ultrafine Particles and Risk of Malignant Brain Cancer: A Multiethnic Cohort Study
Authors: Anna H. Wu, Scott Fruin, Timothy V. Larson, Chiu-Chen Tseng, Jun Wu, Juan Yang, Jennifer Jain, Salma Shariff-Marco, Pushkar P. Inamdar, Veronica W. Setiawan, Jacqueline Porcel, Daniel O. Stram, Loic Le Marchand, Beate Ritz, Iona Cheng
Journal: Cancer Research (2021)

Ultrafine particles (UFP; diameter less than or equal to 100 nm) may reach the brain via systemic circulation or the olfactory tract and have been implicated in the risk of brain tumors. The effects of airport-related UFP on the risk of brain tumors are not known. Here we determined the association between airport-related UFP and risk of incident malignant brain cancer (n = 155) and meningioma (n = 420) diagnosed during 16.4 years of follow-up among 75,936 men and women residing in Los Angeles County from the Multiethnic Cohort study. UFP exposure from aircrafts was estimated for participants who lived within a 53 km × 43 km grid area around the Los Angeles International Airport (LAX) from date of cohort entry (1993-1996) through December 31, 2013. Cox proportional hazards models were used to estimate the effects of time-varying, airport-related UFP exposure on risk of malignant brain cancer and meningioma, adjusting for sex, race/ethnicity, education, and neighborhood socioeconomic status. Malignant brain cancer risk in all subjects combined increased 12% [95% confidence interval (CI), 0.98-1.27] per interquartile range (IQR) of airport-related UFP exposure (∼6,700 particles/cm3) for subjects with any address in the grid area surrounding the LAX airport. In race/ethnicity-stratified analyses, African Americans, the subgroup who had the highest exposure, showed a HR of 1.32 (95% CI, 1.07-1.64) for malignant brain cancer per IQR in UFP exposure. UFP exposure was not related to risk of meningioma overall or by race/ethnicity. These results support the hypothesis that airport-related UFP exposure may be a risk factor for malignant brain cancers. SIGNIFICANCE: Malignant brain cancer risk increases with airport-related UFP exposure, particularly among African Americans, suggesting UFP exposure may be a modifiable risk factor for malignant brain cancer.
Sodium-Glucose Cotransporter 2 Inhibitors vs Sulfonylureas
Authors: Vinay Guduguntla, Richard W. Grant
Journal: JAMA Internal Medicine (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal