tbuckley/cabot-search huggingface dataset:
Correction and Republication: New COVID-19 Cases and Hospitalizations Among Adults, by Vaccination Status — New York, May 3–July 25, 2021
Journal: MMWR Morbidity and Mortality Weekly Report (2021)

On, August 18, 2021, MMWR published "New COVID-19 Cases and Hospitalizations Among Adults, by Vaccination Status - New York, May 3-July 25, 2021" (1). On August 25, 2021, the authors informed MMWR that some analyses were inaccurate because vaccination records of persons with a birth date between two vaccination dates could be counted as two distinct persons with different ages. This resulted in an artificial inflation of the population of partially vaccinated persons, which in turn affected the number of unvaccinated persons because that number is estimated as the total population size minus the fully vaccinated and the partially vaccinated groups. Programming code was adjusted to address this issue as well as three uncommon issues that had a relatively minor impact on findings. First, unvaccinated persons who received positive test results for SARS-CoV-2 who subsequently received a first vaccination dose were not always counted towards the tally of unvaccinated COVID-19 cases. Second, persons who received additional doses before such doses were authorized had their date of full vaccination assigned based on final dose date, rather than series completion date. Third, persons who received doses in both New York City and the other areas of New York required additional deduplication. Using current data from the continuously updated surveillance databases, the authors have corrected the MMWR report accordingly and confirmed that the interpretation and the conclusions of the original report were not affected by these changes (the updated results are highly similar to those of the primary analysis and sensitivity analyses as reported in the original paper). MMWR has republished the report (2), which includes the original report with clearly marked corrections in supplementary materials.
Oral pemphigus and bullous pemphigold. Immunofluorescent studies of two patients
Authors: S. F. Bean
Journal: JAMA (1971)

A patient with oral pemphigus vulgaris and a patient with oral bullous pemphigoid were studied with immunofluorescence. The serum from both patients contained no demonstrable circulating antibodies, but direct staining of specimens obtained from the oral mucosa revealed characteristic fluorescence and established the diagnosis. The lack of circulating epidermal antibodies, therefore, does not rule out pemphigus and bullous pemphigoid. Direct immunofluorescence must be performed in order to exclude these diseases as a cause of chronic blistering of the oral cavity.
Accelerated Approval Is Not Conditional Approval
Authors: Gautam U. Mehta, R. Angelo de Claro, Richard Pazdur
Journal: JAMA Oncology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
LONDON
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The role of vessel size in determining debulking efficiency after directional coronary atherectomy Issam Moussa, Antonio Colombo, Carlo Di Mario, Yoshio Kobayashi, Michael Collins, Milena Adamian, Jeffery W. Moses. Lenox Hill Heart and Vascular Institute, New York, NY, Centro Cuore Columbus, Milan, Italy
Journal: Journal of the American College of Cardiology (2001)
“Dependency Map” Bears Fruit for Childhood Cancers
Journal: Cancer Discovery (2021)

The first comprehensive catalog of genetic vulnerabilities in pediatric tumors has identified dozens of potential new therapeutic targets, mostly in genes not known to harbor activating mutations-many unique to childhood cancers. The findings, part of the Cancer Dependency Map Project, reveal that pediatric cancers, despite their lower mutational burden relative to adult tumors, harbor just as many genes that cancer cells rely upon for growth and survival.
Governing Council Meets With Federal Representatives
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
What's new in the other general journals
Authors: Alison Tonks
Journal: BMJ (2006)

Dehydroepiandrosterone (DHEA) is one of our body's most abundant sex steroids. The abundance declines slowly with age, however, and replacing it has become a fashionable way of maintaining eternal youth. It doesn't work, but that doesn't stop DHEA being peddled as an antiageing panacea by manufacturers happy to exploit a regulatory loophole that defines it as a food supplement rather than a drug. This loophole should be closed, writes one commentator. His Google search for DHEA returned five million hits, many from online vendors making exaggerated and unsubstantiated claims. Credit: N ENGL J MED There is no evidence that replacing DHEA has any effect on the processes of ageing, he writes. A handful of trials have already been published, and the latest simply confirms their negative findings—physiological doses of the hormone taken for two years had no meaningful effect on body composition, physical performance, insulin sensitivity, or quality of life in elderly men or women. Its effect on bone mass was minimal and inconsistent. Physiological doses of testosterone were equally disappointing for the men. Credit: JAMA No one should be taking either DHEA or testosterone to regain lost youth, the commentator concludes. They don't work and may not be safe. DHEA should be reclassified as a drug and properly regulated “or quackery will prevail.” N Engl J Med 2006; 355: 1724–6 1647–59 [OpenUrl][1][CrossRef][2][PubMed][3] More than half of children with acute otitis media could be safely treated with watchful waiting, according to a meta-analysis of randomised trials. Antibiotics should be reserved largely for those with otorrhoea (21% of children, relative risk 0.52 (95% CI 0.37 to 0.73)) and those under the age of 2 years with bilateral infections (20% of children, 0.64 (0.62 to 0.8)), the two subgroups most likely to benefit. In these subgroups, children given antibiotics were significantly less likely to have pain, fever, or both between three … [1]: {openurl}?query=rft.jtitle%253DNew%2BEngland%2BJournal%2Bof%2BMedicine%26rft.stitle%253DNEJM%26rft.issn%253D0028-4793%26rft.aulast%253DStewart%26rft.auinit1%253DP.%2BM.%26rft.volume%253D355%26rft.issue%253D16%26rft.spage%253D1724%26rft.epage%253D1726%26rft.atitle%253DAging%2Band%2BFountain-of-Youth%2BHormones%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMe068189%26rft_id%253Dinfo%253Apmid%252F17050897%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1056/NEJMe068189&link_type=DOI [3]: /lookup/external-ref?access_num=17050897&link_type=MED&atom=%2Fbmj%2F333%2F7574%2F904.atom
Caffeine and benign breast disease
Authors: M. F. Jacobson
Journal: JAMA (1986)

<h3>In Reply.—</h3> We are surprised and gratified by the responses to our small survey,<sup>1</sup>as they reflect continued keen interest in the field of clinical decision theory. Although we recognize the deficiencies and limitations of our informal study, our conclusion that clinicians need further educational support to continue appropriately using prevalence data in the decision to order laboratory testing seems valid. Considering the similarity of our survey to that of Casscells et al,<sup>2</sup>it is not surprising that the objections raised by Drs Fung and Lo and Drs Critchfield and Connelly are reminiscent of those put forth to the previous study.<sup>3</sup>We did, in fact, assume the false-positive rate could be quantified as 1 minus specificity, as is generally accepted.<sup>4</sup>We also believe that the complementary concepts of "falseand true-positive rates" may be easier to remember and be used by clinicians than is "specificity." We did
<b>Highlights</b>
Journal: JAMA Psychiatry (2013)

Benzoate for Schizophrenia 1267Lane and colleagues demonstrate that sodium benzoate, as a D-amino acid oxidase inhibitor, can substantially improve the symptoms and neurocognition of schizophrenia, presumably by improving N-methyl-D-aspartate function by raising D-serine levels.By inhibiting the catabolic enzyme, the treatment is analogous to monoamine oxidase inhibitors, which upregulate monoamine for central nervous system disorders. Boundaries of Schizoaffective Disorder 1276Kotov and colleagues examined the natural boundaries among psychotic disorders by evaluating associations between symptom course and long-term outcome in a sample of 413 first-admission patients with psychosis followed up for 10 years.A sharp distinction between psychotic mood disorders and schizophrenia was observed, but no boundary was found between schizoaffective disorder and schizophrenia.
Comprehensive Management of Cardiovascular Risk Factors for Adults With Type 2 Diabetes: A Scientific Statement From the American Heart Association
Authors: Joshua J. Joseph, Prakash Deedwania, Tushar Acharya, David Aguilar, Deepak L. Bhatt, Deborah A. Chyun, Katherine E. Di Palo, Sherita H. Golden, Laurence S. Sperling
Journal: Circulation (2022)

Cardiovascular disease remains the leading cause of death in patients with diabetes. Cardiovascular disease in diabetes is multifactorial, and control of the cardiovascular risk factors leads to substantial reductions in cardiovascular events. The 2015 American Heart Association and American Diabetes Association scientific statement, "Update on Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes Mellitus in Light of Recent Evidence," highlighted the importance of modifying various risk factors responsible for cardiovascular disease in diabetes. At the time, there was limited evidence to suggest that glucose-lowering medications reduce the risk of cardiovascular events. At present, several large randomized controlled trials with newer antihyperglycemic agents have been completed, demonstrating cardiovascular safety and reduction in cardiovascular outcomes, including cardiovascular death, myocardial infarction, stroke, and heart failure. This AHA scientific statement update focuses on (1) the evidence and clinical utility of newer antihyperglycemic agents in improving glycemic control and reducing cardiovascular events in diabetes; (2) the impact of blood pressure control on cardiovascular events in diabetes; and (3) the role of newer lipid-lowering therapies in comprehensive cardiovascular risk management in adults with diabetes. This scientific statement addresses the continued importance of lifestyle interventions, pharmacological therapy, and surgical interventions to curb the epidemic of obesity and metabolic syndrome, important precursors of prediabetes, diabetes, and comorbid cardiovascular disease. Last, this scientific statement explores the critical importance of the social determinants of health and health equity in the continuum of care in diabetes and cardiovascular disease.
Bulletin Johns Hopkins Hospital, Baltimore
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Performance of lateral flow assays for SARS-CoV-2 compared to RT-qPCR
Authors: Matthias Pilecky, Stephan Harm, Christoph Bauer, Jennifer Zottl, Robert Emprechtinger, Tanja Eichhorn, Claudia Schildböck, Michael Ecker, Martin Willheim, Viktoria Weber, Jens Hartmann
Journal: Journal of Infection (2022)
Infectious disease surveillance update
Authors: Ruth Zwizwai
Journal: The Lancet Infectious Diseases (2016)

Public health officials in Kenya have reported cutaneous anthrax disease in residents who fell ill after eating meat from the carcasses of infected cows. The residents were from Nakuru province, where public health officials are on high alert. As of July 3, 70 cases had been reported; all patients are being treated with antibiotics at health centres in Rongal subcounty, as well as anyone else who consumed or handled the meat. The residents reported that they consumed meat from ten infected cow carcasses in the period of June 17–20.
Psychotropic Drug Use in Children and Adolescents Before and During the COVID-19 Pandemic
Authors: Christine Leong, Laurence Y. Katz, James M. Bolton, Murray W. Enns, Joseph Delaney, Qier Tan, Jitender Sareen
Journal: JAMA Pediatrics (2022)

included bronchiolitis, pneumonia, asthma, and major depressive disorder.
Does CB-1 in hepatic stellate cells contribute to liver fibrosis?
Authors: Sophie Lotersztajn, Ariane Mallat
Journal: Journal of Clinical Investigation (2022)

To the Editor: The development of drugs targeting the peripheral cannabinoid receptor 1 (CB-1) has been identified as a major therapeutic opening for the management of nonalcoholic fatty liver disease (NAFLD) and liver fibrosis (1).Studies from our laboratory and that of George Kunos identified the endocannabinoid system and CB-1 in hepatic stellate cells (HSCs) and hepatocytes as major drivers of fibrogenesis and steatogenesis, findings that were confirmed by several teams (1, 2).The article by Wang et al.(3) challenges this current view, but we have concerns regarding their data and conclusions.Wang et al. claim that CB-1 was not induced in hepatocytes or HSCs in their NAFLD and fibrosis models.However, their study was limited to the analysis of CB-1 mRNA variations, and their results contradict a large number of studies involving rodent and human liver samples as well as isolated hepatocytes and HSCs that combined mRNA and protein analysis and functional studies (1, 2).Moreover, we have several methodological concerns: (a) single-cell RNA-Seq was performed in HSCs from high-fat diet-fed mice, a model in which HSCs are hardly activated; (b) the lack of detection of CB-1 in HSCs in human liver samples is questionable, since their histological images did not show fibrosis or markers of HSC activation.Finally, the authors used mice deficient for CB-1 in HSCs to evaluate the role of these cells in fibrogenesis and found no differences in the amount of fibrosis between KO and wild-type mice.On the basis of these findings, they questioned the antifibrogenic potential of peripherally restricted CB-1 antagonists.However, they did not perform functional studies to validate the impact of CB-1 deletion in HSCs on CB-1 signaling and/or fibrogenic properties.Moreover, Picrosirius red staining quantification of fibrosis was performed on a limited number (n = 3) of animals per group.Finally, we believe that their conclusion is simplistic, since liver fibrosis results from coordinated interactions of HSCs with macrophages, endothelial cells, and hepatocytes, all of which express CB-1.In fact, the antifibrogenic efficacy of peripherally restricted CB-1 antagonists has been well demonstrated in rodents (4).
THE BATTLING EDITOR
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Feasibility of open heart surgery in a community hospital
Authors: A. H. Khazei
Journal: JAMA (1975)

A program for open heart surgery in one community hospital was formulated and put into practice. Experience gained indicates that such services are a necessity in hospitals that fulfill certain criteria. The program is safe and inexpensive. A house staff is not a prerequisite. Finally, the analysis of data obtained from the first 100 cases compares very favorably with results in large medical centers, indicating that the patient's recovery is not compromised. (<i>JAMA</i>232:154-156, 1975)
SOCIETY NEWS.
Authors: E. J. Overend
Journal: JAMA (1898)

micro-organisms gain access to the bladder; the treatment of suppurative cystitis; cystitis due to specific organisms.Moullin is well known through his system of surgery (which has had a wide circulation in this country) as a practitioner of ability and vast experience.The monograph under consider- ation is one deserving of the highest consideration.We com- mend the work to our readers.
Re: Jean F.P. Lestingi, Giuliano B. Guglielmetti, Quoc-Dien Trinh, et al. Extended Versus Limited Pelvic Lymph Node Dissection During Radical Prostatectomy for Intermediate- and High-risk Prostate Cancer: Early Oncological Outcomes from a Randomized Phase 3 Trial. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.11.040
Authors: Alberto Briganti, Giorgio Gandaglia, Markus Graefen, Steven Joniau, R. Jeffrey Karnes, Francesco Montorsi
Journal: European Urology (2021)
Attenuated endothelium-dependent vasodilation in patients with coronary artery disease: Impact of G894T polymorphism of the endothelial nitric oxide synthase Rainer Hambrecht, Sandra Erbs, Volker Adams, Axel Linke, Stephan Gielen, Gerhard Schuler. University Leipzig, Heart Center, Leipzig, Germany
Journal: Journal of the American College of Cardiology (2001)
Numerical Error in Associated Review Article in: Circumcision and HIV Prevention Among Men Who Have Sex With Men: No Final Word
Journal: JAMA (2009)

a numerical error was published.On page 1698, in sentence 5 of paragraph 4, the odds ratio should have read "0.95 (95% confidence interval, 0.81-1.11)."This incorrect odds ratio occurred because of an error in the spreadsheet computations of the random-effects variance estimate in the asso