tbuckley/cabot-search huggingface dataset:
Scranton Mothers in War Industries
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Performance of Vibration-Controlled Transient Elastography and Clinical Prediction Models In Liver Transplant Recipients
Authors: Mohammad Shadab Siddiqui, Anh T. Bui, Taseen Syed, Michael Tseng, Ramzi Hassouneh, Chandra S. Bhati, Cheng Han Ng, Tamoore Arshad, Austin Miller, Sean Flynn, Vaishali Patel, Amon Asgharpour, Sohum Patel, Michael O. Idowu, Mark Muthiah
Journal: Clinical Gastroenterology and Hepatology (2022)
Abstract 203: A Pilot Study of Using Ice Slurry to Rapidly Induce Hypothermia in a Swine Model of Cardiac Arrest
Authors: Yue Shao, Lynn Bailey, Yue Wu
Journal: Circulation (2018)

Background: Therapeutic Hypothermia has been recommended by AHA to treat Out of Hospital Cardiac Arrest (OHCA) patients. Animal studies shown that the less time to reach target temperature (TT), the better the clinical outcome. Some animal experiments even suggested that there is an optimal time window that within which the TT should be reached for optimal outcome. In this pilot study, we developed a medical device to infuse a novel medical coolant, ice slurry which is a partially frozen saline, into the blood vessel to rapidly cool the brain. We aimed to evaluate the time to cool the brain temperature down to TT, which is 3°C below normal body temperature, in a swine model of OHCA protocol. Methods: Three Yorkshire swine between 40-50 kg were anesthetized. Bilateral temporal craniotomies were performed for placement of thermocouples at a depth of 1.25 cm for recording cortical temperatures. Two additional thermocouples were placed in esophageal and rectal for measuring the body temperature. A 9.5 French catheter was placed in the right femoral vein for ice slurry infusion. Ventricular fibrillation (VF) was induced by the occlusion of left anterior descending artery. After the onset of VF, there was a 3-minute stand-by followed by a 7-minute chest compression. Ice slurry infusion started at 10 minutes after the onset of VF. Ice slurry with a dosage of 50mL/kg body weight (up to 2L) was infused at constant flow rate while chest compression continues. Chest compressions continued throughout the slurry administration and for 3 minutes post infusion. Thermocouple data were recorded every second for offline processing. Results: In swine 1, 1970mL of ice slurry with 13% of ice fraction was infused into a 40kg pig at a flow rate of 120mL/min. The TT was reached at 22 minutes after the start of infusion. In swine 2 and 3, 2000mL of ice slurry with 25% of ice fraction was infused at 150mL/min into pigs with 49.7 kg and 41.7kg body weight, respectively. The TT were reached at 13min and 15min, respectively. Conclusions: Ice slurry infusion rapidly lowered the cortical temperature of young swine model in cardiac arrest. This rapid cooling method may meet the optimal time window suggested by animal experiment for dramatically improve the survival rate and neurologic outcome of OHCA.
A Clinical Manual of Skin Diseases, with Especial Reference to Diagnosis and Treatment. For the use of students and general practitioners.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Spinal Anaesthesia
Authors: L. Doyle
Journal: BMJ (1936)

TREATMEINT o01 ASTHMA BY t3LThA-IOLET LG{ i reason of the greater wealth of ultra-violet rays in the solar spectrum at those heights.Unfortunately, even this mechainism fails to explain all the clinical phenomena.For example, Case I, during his asthmatic attack, was apparently suffering from acute suprarenal dysfunction which means either that there was an inadequacy of dopa- substance, or else that the suprarenals were failing to convert it to adrenaline.The fact that he did not pigment in an Addisonian manner does not necessarily indicate the latter; it may have been too slight to be noticeable.He was given suprarenal extract (empirically) by mouth, and this was followed by improvement.But we do not know the real effect of suprarenal extract given by mouth.It may be the adrenaline content that is absorbed, or a ferment-in which the suprarenals are temporarily deficient-for converting dopa-substance into adrenaline.Whichever it may be, the whole scheme breaks down when the patient-on regaining his supra- renal function and normal blood pressure-develops an attack of asthma.One would have expected him to do this earlier, when his adrenaline production was at a low ebb.The only possible (and to my mind rather weak) plea is that he may not have had the allergic provocation during that time.Then the coma by which Case II distinguished himself cannot be explained by this mechanism.Summary 1.The beneficial effects of actinotherapy in cases of asthma cannot be attributed alone to the suggestibility of the patient.2. At present no theory can be propounded which covers all the clinical observations.3. The most striking clinical observation-that is, the relation between immunity and pigmentation-leads me to propound a theory involving the relation of adrenaline and melanin.4. It is perhaps noteworthy that in none of these twelve asthmatic patients or in any of the fifty to sixty patients treated by ultra-violet rays for other conditions has pulmonary tuberculosis manifested itself either during treatment or subsequently.
Necrobacillosis
Authors: S Hudson, A C Maddocks, A Stacey
Journal: BMJ (1984)

<h3>Abstract</h3> 3D single-molecule localization microscopy relies on fitting the shape of point-spread-functions (PSFs) recorded on a wide-field detector. However, optical aberrations distort those shapes, which compromise the accuracy and precision of single-molecule localization microscopy. Here we employ a computational phase retrieval based on a vectorial PSF model to quantify the spatially-variance of optical aberrations in a two-channel ultrawide-field single-molecule localization microscope. The use of a spatially-variant PSF model enables accurate and precise emitter localization in <i>x</i>, <i>y</i>- and <i>z</i>-directions throughout the entire field-of-view. <h3>OCIS Codes</h3> (100.6640) Superresolution; (180.2520) Fluorescence microscopy; (180.6900) Three-dimensional microscopy; (100.5070) Phase retrieval; (150.1135) Algorithms; (220.1010) Aberrations (global).
Diagnostic and therapeutic technology assessment. Transrectal ultrasonography--reassessment
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 160: End-Tidal Carbon Dioxide &gt; 20mmHg During Pediatric In-Hospital Cardiopulmonary Resuscitation is not Associated With Survival
Authors: Robert A Berg, Ronald W Reeder, Kathleen L Meert, Andrew R Yates, John T Berger, Christopher J Newth, Joseph A Carcillo, Patrick S McQuillen, Rick E Harrison, Frank W Moler, Murray M Pollack, Todd C Carpenter, Daniel A Notterman, Richard Holubkov, Michael Dean, Vinay M Nadkarni, Robert M Sutton
Journal: Circulation (2018)

Introduction: Based on laboratory CPR investigations and limited adult data, the American Heart Association Consensus Statement on CPR Quality recommends titrating end-tidal carbon dioxide (ETCO2) to &amp;gt; 20 mmHg during CPR. Hypothesis: ETCO2 &amp;gt; 20 mmHg during pediatric in-hospital CPR is associated with survival to hospital discharge. Methods: Children &amp;gt; 37 weeks gestation in Collaborative Pediatric Critical Care Research Network intensive care units with chest compressions for &amp;gt; 1 minute and ETCO2 monitoring prior to and during CPR between July 1, 2013 and June 31, 2016 were included. ETCO2 and Utstein-style cardiac arrest data were collected. Multivariable Poisson regression models with robust error estimates were used to estimate relative risk of outcomes. Results: Investigators blinded to outcome analyzed ETCO2 waveforms from 43 children for the first (up to) 10 minutes of CPR. During CPR, the median ETCO2 was 23 mmHg (quartiles, 16 and 28 mmHg), median ventilation rate was 29 breaths/minute (quartiles, 24 and 35 bpm), and median duration of CPR was 5 minutes [quartiles, 2 and 16 minutes]. Return of spontaneous circulation occurred after 71% of CPR events and 37% of patients survived to hospital discharge. For children with mean ETCO2 during CPR &amp;gt; 20 mmHg, the adjusted relative risk for return of spontaneous circulation was 1.32 (0.89, 1.95), p= 0.16 and for survival to hospital discharge was 0.92 (0.41, 2.08), p= 0.84. Further sensitivity analyses were unable to demonstrate an association between mean ETCO2 &amp;gt; 25 mmHg or &amp;gt; 30 mmHg and ROSC or survival to hospital discharge. The median mean ETCO2 among children who survived to hospital discharge was 20 mmHg [quartiles; 15, 28 mmHg] versus 23 mmHg [16, 28 mmHg] among non-survivors. Conclusion: Mean ETCO2 &amp;gt; 20 mmHg during pediatric in-hospital CPR was not associated with ROSC or survival to hospital discharge. ETCO2 was not demonstrably different among survivors versus non-survivors.
Instructions to Authors
Journal: Hepatology (2022)

HepatologyVolume 75, Issue 3 ISSUE INFORMATIONFree Access Instructions to Authors First published: 14 February 2022 https://doi.org/10.1002/hep.31935AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume75, Issue3March 2022 RelatedInformation
Abstract 250: Pre-Hospital Factors and Survival After Out-of-Hospital Cardiac Arrest According to Patient Income and Education; a Danish Nationwide Study
Authors: Sidsel Møller, Fredrik Folke, Carolina Malta Hansen Hansen, Steen Møller Hansen, Freddy Lippert, Lars Køber, Shahzleen Rajan, Kristian Kragholm, Lena Karlsson, Gunnar Gislason, Christian Thorp-Pedersen, Mads Wissenberg
Journal: Circulation (2018)

Introduction: Little is known about how patient socioeconomic status (income and education), relates to chance of bystander cardiopulmonary resuscitation (CPR) and survival after out-of-hospital cardiac arrest (OHCA). We assessed the association between patient socioeconomic status and bystander CPR as well as 30-day survival. Methods: OHCA patients ≥30 years of age and of presumed cardiac cause were identified through the nationwide Danish Cardiac Arrest Register, 2001-2014, and divided into high, medium and low subgroups according to 1) tertiles of household income from the year prior to OHCA and 2) highest degree of education according to the International Standard Classification of Education (ISCED) (&lt;10 years, 10-12 years and &gt;12 years of education). Associations of income and education with bystander CPR and 30-day survival were estimated using logistic multivariable logistic regression analysis adjusted for age, gender and calendar year. Results: In total, 25,233 OHCAs were included. Comparing patients in the highest group with patients in the lowest group of income and education, patients in the highest groups were younger, less often female and had less comorbidities. Patients in the highest groups were more likely to have: public arrests (income: 31.6% vs. 22.5%, education: 30.9% vs. 24.3%), witnessed arrests (income: 55.3% vs. 50.2%, education: 56.6% vs. 50.4%), bystander CPR (income: 52.4% vs. 34.7%, education: 51.6% vs. 40.9%) and an initial shockable heart rhythm (income: 37.6% vs. 22.1%, education: 35.7% vs. 24.1%), all p&lt;0.001. High income and education compared to low were also associated with higher survival upon hospital arrival (income: 23.4% vs. 13.1%, education: 23.8% vs. 15.0%) and 30-day survival (income: 15.8% vs. 4.5%, education: 15.4% vs. 6.3%), p&lt;0.001. Differences persisted in adjusted analyses: bystander CPR (high vs. low, income OR 1.43 95%CI 1.32-1.54, education OR 1.27 95%CI 1.17-1.39) and for 30-day survival (high vs. low, income OR 2.01 95%CI 1.74-2.31, education OR 2.08 95%CI 1.83-2.36). Conclusions: In this nationwide study of OHCA patients, higher socioeconomics status (income and education) was associated with higher rates of bystander CPR and 30-day survival, compared with those with lower socioeconomic status.
Genomic characterization of patients (pts) with de-novo high-volume metastatic castration-sensitive prostate cancer (dn-hv-mCSPC) compared to those without dn-hv-mCSPC.
Authors: Nicolas Sayegh, Yeonjung Jo, Nishita Tripathi, Taylor Ryan McFarland, Adam Kessel, Roberto Nussenzveig, Beverly Chigarira, Haoran Li, Clara Tandar, Kamal Kant Sahu, Benjamin Haaland, Benjamin L. Maughan, Umang Swami, Neeraj Agarwal
Journal: Journal of Clinical Oncology (2022)

186 Background: Dn-hv-mCSPC have the poorest survival outcomes among various subsets pts with mCSPC (Fizazi, Lancet Oncol 2019). However, the molecular underpinnings behind the poor prognosis is not entirely understood. In this study, we aimed to assess the tumoral genomic characteristics in pts with dn-hv-mCSPC. Methods: In this IRB-approved study, patient-level data were collected retrospectively. Eligibility: patients with mCSPC with availability of tumor comprehensive genomic profiling (CGP) from a CLIA-certified lab before start of ADT. Clinically relevant genes previously reported to be associated with prognosis in metastatic prostate cancer were included: TP53, PTEN, RB1, BRCA2, CDK12, MYC, PIK3CA, SPOP, APC, CTNNB1, and, ATM. Variants of unknown significance and genomic aberrations present in &lt; 5% pts were excluded. High-volume disease was defined per CHAARTED criteria. Genomic aberration prevalence was compared using a Chi-square test and was adjusted for false discovery (Benjamini-Hochberg). Results: 304 pts were eligible: dn-hv-mCSPC (N = 100) vs non-dn-hv-mCSPC (N = 204); median age 67 vs 63 years, median PSA at baseline 35 vs 14 ng/mL, median Gleason score 9 vs 9, visceral metastases 15% vs 3%. 41% and 27% of pts had ≥2 mutations in the dn-hv-mcSPC and non-dn-hv-mCSPC respectively (P = 0.01). Overall, most commonly mutated genes were TP53, TMPRSS2, and PTEN. Pts with dn-hv-mCSPC had higher frequency of TP53 (P = 0.016) and BRCA2 (P = 0.03) mutations. Conclusions: In this real-world patient population, dn-hv-mCSPC pts were shown to have a greater number of clinically relevant genomic aberrations. Detailed genomic landscape of these pts will be presented in the meeting. These hypotheses-generating data need external validation.
Decline of immune humoral response after BNT162b2 vaccine
Authors: Sonia Ferri, Alessandro Polidoro, Marco Ciacciarelli, Umberto Ceratti, Viviana Congedo, Maria Mele, Graziella Coluzzi, Alessandra Spagnoli, Luigi Iuliano
Journal: Journal of Infection (2022)

Highlights•There is the need to better understand the humoral immunity response to mRNA vaccines against SARS-CoV-2 in a real world setting.•In response to BNT162b2 we observed that at peak immunity anti-SP IgG titer range was wide, spanning more than two orders of magnitude.•Anti-spike IgG declined over time to reach a residual value of about 18% at 28 weeks.•Our results support the use of booster doses.
Münchener Medizinische Wochenschrift
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Statistical properties of normal distribution
Authors: E. Markowitz
Journal: JAMA (1969)

<h3>To the Editor:—</h3> I have some doubts that electroencephalographic tracings always tell the exact truth about the viability of the brain. It seems possible that portions of the recordings obtained after pupillary fixation are due to artifacts. The thought of spurious effects comes to mind after reading about EEGs obtained from cat brain stored for more than a month at below zero temperatures. Recent advances in technology concerning remnant electric effects point in the same direction. Many briefly electrified biological substances display long-lasting electrical "excitability" which persists even after short-circuiting and extended periods of storage. In view of these observations we may wish to reevaluate the present medical consensus that the "flat" EEG is the only reliable proof of brain death and, conversely, that all electrocortical activity is a sign of life. Such study may improve the understanding of the terminal phenomena of life and lessen the extraordinary measures to
Respiratory sequelae of whooping cough. Swansea Research Unit of the Royal College of General Practitioners.
Journal: BMJ (1985)

Eight hundred and thirteen children who had had whooping cough when under 5 years of age in the 1977-9 epidemic were compared with a control group roughly four and a half years later, each child being matched by age and sex and from the same class in school. The index group showed long term respiratory sequelae of whooping cough--namely, deterioration in lung function, increase in respiratory symptoms, and increased admission to hospital for both upper and lower respiratory conditions. Asthma was significantly more common in the index group, suggesting that asthma was being regarded as a contraindication to pertussis vaccination. Only 3.5% of the asthmatic children in the index group had been vaccinated as against 29.1% of the controls.
Umbilical Hernia
Authors: Y. H. Misomali
Journal: BMJ (1966)

child to hospital if it seems possible that it has been deliberately injured, whether by parents or baby-minder or older sibling.The child is then in a " place of safety " and can be kept there, as the B.P.A. memorandum makes clear.But once it is there, the best interests of the baby and the rehabilitation of the parents are not contradictory aims: they are joint ones, and the apparatus for dealing with both is available.-Iam, etc.,
Subclinical brucellosis.
Authors: E Williams
Journal: BMJ (1973)

severe pre-eclampsia may occur early enough to retard fetal growth.It is therefore im- portant to distinguish between pre-eclawpsia and eclampsia in such comparisons.The relatively small percentage of Yoruba primigravidae who are over 25 years of age tend to be overweight and to show a higher than average incidence of pre-eclampsia during pregnancy of the type seen in Europe.These women are usually in non- manual occupations.There is good evidence that hy,pertension is common in Yoruba women in middle life.-I am, etc.,