Responses to a Neutralizing Monoclonal Antibody for Hospitalized Patients With COVID-19 According to Baseline Antibody and Antigen Levels
Authors: Jens D. Lundgren, Birgit Grund, Christina E. Barkauskas, Thomas L. Holland, Robert L. Gottlieb, Uriel Sandkovsky, Samuel M. Brown, Kirk U. Knowlton, Wesley H. Self, D. Clark Files, Mamta K. Jain, Thomas Benfield, Michael E. Bowdish, Bradley G. Leshnower, Jason V. Baker, Jens-Ulrik Jensen, Edward M. Gardner, Adit A. Ginde, Estelle S. Harris, Isik S. Johansen, Norman Markowitz, Michael A. Matthay, Lars Østergaard, Christina C. Chang, Anna L. Goodman, Weizhong Chang, Robin L. Dewar, Norman P. Gerry, Elizabeth S. Higgs, Helene Highbarger, Daniel D. Murray, Thomas A. Murray, Ven Natarajan, Roger Paredes, Mahesh K.B. Parmar, Andrew N. Phillips, Cavan Reilly, Adam W. Rupert, Shweta Sharma, Kathryn Shaw-Saliba, Brad T. Sherman, Marc Teitelbaum, Deborah Wentworth, Huyen Cao, Paul Klekotka, Abdel G. Babiker, Victoria J. Davey, Annetine C. Gelijns, Virginia L. Kan, Mark N. Polizzotto, B. Taylor Thompson, H. Clifford Lane, James D. Neaton, H. Clifford Lane, John Tierney, Elizabeth S. Higgs, Kevin Barrett, Betsey R. Herpin, Mary C. Smolskis, Susan E. Vogel, Laura A. McNay, Kelly Cahill, Page Crew, Matthew Kirchoff, Ratna Sardana, Sharon Segal Raim, Kathryn Shaw-Saliba, Stacey J. Adam, Sarah Read, Eric Hughes, Rachel H. Harrigan, R. Baseler, Marc J. Teitelbaum, Shelly M. Simpson, Molly J. Buehn, David Vallée, Vanessa Eccard-Koons, Stacey Kopka, Theresa M. Engel, Cynthia Osborne, Leah Giambarresi MacDonald, Liam M. Harmon, Denise M. Shelley, Mi Ha Kim, Joy Beeler-Knights, Lindsey Yeon, Robin L. Dewar, Ven Natarajan, Weizhong Chang, Brad T. Sherman, Adam W. Rupert, Helene Highbarger, Michael Baseler, Perrine Lallemand, Tauseef Rehman, Danielle Lynam, Gregg Mendez, Tom Imamichi, Sylvain Laverdure, Sharada Paudel, Kyndal Cook, Shawn Brown, Ayub Khan, Allison Hazen, Yunden Badralmaa, James D. Neaton, Laura Amos, Anita Carter, Gary Collins, Bionca Davis, Eileen Denning, Alain DuChene, Nicole Engen, Greg Grandits, Birgit Grund, Merrie Harrison, Nancy Hurlbut, Joseph Koopmeiners, Gregg Larson, Sue Meger, Shweta Sharma Mistry, Thomas Murray, Ray Nelson, Kien Quan, Siu Fun Quan, Cavan Reilly, Greg Thompson, David Vock, Deborah Wentworth, Annetine C. Gelijns, Alan J. Moskowitz, Emilia Bagiella, Ellen Moquete, Karen O’Sullivan, Evan Accardi, Emily Kinzel, Gabriela Bedoya, Lopa Gupta, Jessica R. Overbey, Maria L. Padillia, Milerva Santos, Marissa A. Miller, Wendy C. Taddei-Peters, Kathleen Fenton, Peter K. Smith, Christina E. Barkauskas, Andrew M. Vekstein, Emily R. Ko, Tatyana Der, John Franzone, Noel Ivey, Thomas L. Holland, Kathleen Lane, Andrew Bouffler, Lauren M. McGowan, Ben Stallings, Jennifer Stout, Whitney Franz, Beth McLendon-Arvik, Beth A. Hollister, Dana M. Giangiacomo, Uriel Sandkovsky, Robert L. Gottlieb, Michael Mack, Mezgebe Berhe, Clinton Haley, Emma Dishner, Christopher Bettacchi, Kevin Golden, Erin Duhaime, Cedric Spak, Sarah Burris, Felecia Jones, Samantha Villa, Samantha Wang, Raven Robert, Tanquinisha Coleman, Laura Clariday, Rebecca Baker, Mariana Hurutado, Nazia Iram, Michelle Fresnedo, Allyson Davis, Kiara Leonard, Noelia Ramierez, Jon Thammavong, Krizia Duque, Emma Turner, Aaron Killian, Adriana Palacious, Edilia Solis, Janet Jerrow, Matthew Watts, Heather Whitacre, Elizabeth Cothran, Michael E. Bowdish, Zea Borok, Noah Wald-Dickler, Douglass Hutcheon, Amytis Towfighi, May Lee, Meghan R. Lewis, Brad Spellberg, Linda Sher, Aniket Sharma, Anna P. Olds, Chris Justino, Edward Lozano, Chris Romero, Janet Leong, Valentina Rodina, Christine Quesada, Luke Hamilton, Jose Escobar, Brad Leshnower, William Bender, Milad Sharifpour, Jeffrey Miller, Kim T. Baio, Mary K. McBride, Michele Fielding, Sonya Mathewson, Kristina Porte, Missy Maton, Chari Ponder, Elizabeth Haley, Christine Spainhour, Susan Rogers, Derrick Tyler, Jeffrey M. Sturek, Andrew Barros, Kyle B. Enfield, China J. Green, Rachel M. Simon, Kara Thornton, Patrick E. Parrino, Stephen Spindel, Aditya Bansal, Katherine Baumgarten, Jonathan Hand, Derek Vonderhaar, Bobby Nossaman, Sylvia Laudun, DeAnna Ames, Geralyn Isaac, Huan Dinh, Yiling Zheng, Hunter McDaniel, Nicolle Crovetto, Abby Richardson, Vinay Badhwar, J. Awori Hayanga, Sunil Sharma, Brian Peppers, Paul McCarthy, Troy Krupica, Arif Sarwari, Rebecca Reece, Lisa Fornaresio, Chad Glaze, Raquel Evans, Fang Di, Shawn Carlson, Tanja Aucremanne, Connie Tennant, Lisa Giblin Sutton, Sabrina Buterbaugh, Roger Williams, Robin Bunner, Ronson J. Madathil, Joseph Rabin, Andrea Levine, Kapil Saharia, Ali Tabatabai, Christine Lau, James S. Gammie, Maya-Loren Peguero, Kimberly McKernan, Matthew Audette, Emily Fleischmann, Kreshta Akbari, Myounghee Lee, Andrew Chi, Hanna Salehi, Alan Pariser, Phuong Tran Nyguyen, Jessica Moore, Adrienne Gee, Shelika Vincent, Richard A. Zuckerman, Alexander Iribarne, Sara Metzler, Samantha Shipman, Taylor Caccia, Haley Johnson, Crystallee Newton, Doug Parr, Vicente Rodriguez, Gordon Bokhart, Sharon M. Eichman, B. Taylor Thompson, Crystal North, Cathryn Oldmixon, Nancy Ringwood, Laura Fitzgerald, Ariela Muzikansky, Richard Morse, Roy G. Brower, Lora A. Reineck, Neil R. Aggarwal, Peter Hou, Jay S. Steingrub, Mark A. Tidswell, Lori-Ann Kozikowski, Cynthia Kardos, Leslie De Souza, Daniel Talmor, Nathan Shapiro, Alan E. Jones, James Galbraith, Utsav Nandi, Rebekah Peacock, Michael R. Filbin, Kathryn Hibbert, Blair Alden Parry, Justin D. Margolin, Kelsey Brait, Gregory Hendey, Michael A. Matthay, Kirsten N. Kangelaris, Kimberly J. Yee, Alejandra E. Jauregui, Hanjing Zhuo, Eyad Almasri, Alyssa R. Hughes, Rebekah L. Garcia, Kinsley A. Hubel, Angela J. Rogers, Jennifer G. Wilson, Rosemary Vojnik, Jonasel Roque, Henry Wang, Ryan M. Huebinger, Bela Patel, Elizabeth Vidales, Adit A. Ginde, Amiran Baduashvili, Lakshmi Chauhan, David J. Douin, Lani L. Finck, Carrie Higgins, Michelle Howell, Jeffrey McKeehan, Marc Moss, James H. Finigan, William Janssen, Peter Stubenrauch, Christine Griesmer, Robert C. Hyzy, Pauline K. Park, Kristine Nelson, Kelli McDonough, Jake I. McSparron, Ivan N. Co, Bonnie R. Wang, Shijing Jia, Barbara Sullins, Sinan Hanna, Norman Olbrich, Lynne D. Richardson, Michelle N. Gong, Rahul Nair, Jarrod M. Mosier, Cameron Hypes, Elizabeth Salvagio Campbell, Billie Bixby, Christian Bime, Sairam Parthasarathy, R. Duncan Hite, Thomas E. Terndrup, Herbert P. Wiedemann, Abhijit Duggal, Siddharth Dugar, Debasis Sahoo, Kiran Ashok, Alexander H. King, Omar Mehkri, Nicholas J. Johnson, Bryce H. Robinson, Stephanie J. Gundel, Sarah C. Katsandres, Catherine L. Hough, Akram Khan, Olivia F. Krol, Mistry Kinjal, Milad K. Jouzestani, Peter Chen, Sam S. Torbati, Yuri Matusov, June Choe, Niree A. Hindoyan, Susan E. Jackman, Emad Bayoumi, Timothy Wynter, Antonina Caudill, Ethan Pascual, Gregg J. Clapham, Lisa Herrera, Chadwick Miller, D. Clark Files, Keven W. Gibbs, Lori S. Flores, Mary E. LaRose, Leigha D. Landreth, Peter E. Morris, Jamie L. Sturgill, Evan P. Cassity, Sanjay Dhar, Ashley A. Montgomery-Yates, Sara N. Pasha, Kirby P. Mayer, Marjolein de Wit, Jessica Mason, Samuel M. Brown, Joseph Bledsoe, Kirk U. Knowlton, Michael Lanspa, Lindsey Leither, Ithan Pelton, Brent P. Armbruster, Quinn Montgomery, Darrin Applegate, Naresh Kumar, Melissa Fergus, Katie Brown, Mardee Merrill, Erna Serezlic, Ghazal Palmer, Brandon Webb, Valerie T. Aston, Estelle S. Harris, Elizabeth A. Middleton, Macy A.G. Barrios, Jorden Greer, Amber D. Schmidt, Melissa K. Webb, Robert Paine, Sean J. Callahan, Wesley H. Self, Todd W. Rice, Jonathan D. Casey, Jakea Johnson, Christopher Gray, Margaret Hays, Megan Roth, Virginia L. Kan, Adriana Sánchez, Laura Popielski, Heather Rivasplata, Melissa Turner, Michael J. Vjecha, Amy Weintrob, Mamta K. Jain, Tianna Petersen, Claudia Sanchez Lucas, Alexis Avery, Laura Hansen, Natalie DellaValle, Khanh-Hau Moss, Jason V. Baker, Jonathan Klaphake, Shari Mackedanz, Rachael Goldsmith, Hodan Jibrell, Norman Markowitz, Erika Pastor, Mayur Ramesh, Indira Brar, Emanuel Rivers, Edward Gardner, James Scott, David Wyles, Ivor Douglas, Jason Haukoos, Mitch Cohen, Kevin Kamis, Caitlin Robinson, Princy Kumar, Maximilian Menna, Victoria J. Davey, Kousick Biswas, Cristin Harrington, Barbara W. Trautner, Lavannya Pandit, Laura Dillon, Casey Hines-Munson, Biju Johnson, Marilyn Joseph, John Van, Yiqun Wang, Paola Lichtenberger, Gio Baracco, Carol Ramos, Lauren Bjork, Melyssa Sueiro, Phyllis Tien, Heather Freasier, Theresa Buck, Hafida Nekach, Jens D. Lundgren, Dorthe Raben, Daniel D. Murray, Lars Peters, Bitten Aagaard, Charlotte B. Nielsen, Katharina Krapp, Bente Rosdahl Nykjær, Katja Lisa Kanne, Anne Louise Grevsen, Zillah Maria Joensen, Tina Bruun, Thomas Benfield, Clara Lundetoft Clausen, Nichlas Hovmand, Simone Bastrup Israelsen, Louise Krohn-Dehli, Cæcilie Leding, Dorthe Pedersen, Karen Brorup Pedersen, Louise Thorlacius-Ussing, Michaela Tinggaard, Sandra Tingsgård, Signe Villadsen, Jens-Ulrik Stæhr Jensen, Dorthe S. Høgsberg, Christian P. Rønn, Ema Rastoder, Christian Søborg, Christina Bergsøe, Nuria M.S. Hissabu, Bodil C. Arp, Lars Østergaard, Nina Breinholt Stærke, Andreas Arnholdt Pedersen, Inge K. Holden, Marie Helleberg, Jan Gerstoft, Tomas O. Jensen, Birgitte Lindegaard, Birgit Thorup Røge, Henrik Nielsen, Anna Chamorro, Ariadna Figuerola, Maria Exposito, Roger Paredes, Lourdes Mateu, Ana Martínez, Adrian Siles, Eduardo Fernández-Cruz, Javier Carbone, Paco López, José Muñoz, Daniel Camprubí, Almudena Legarda, Jose R. Arribas, Alberto Borobia, Marta Mora-Rillo, Irene García García, Vicente Estrada, Noemi Cabello, Maria Jose Nuñez, Juan P. Horcajada, Elena Sendra, Joan Gómez-Junyent, Mark Polizzotto, Gesalit Cabrera, Catherine Carey, Christina C. Chang, Sally Hough, Sophie Virachit, Amy Zhong, Barnaby E. Young, Po Ying Chia, Tau Hong Lee, Ray J. Lin, David Lye, Sean Ong, Ser Hon Puah, Tsin Wen Yeo, Shiau Hui Diong, Juwinda Ongko, Abdel G. Babiker, Sarah L. Pett, Fleur Hudson, Mahesh K.B. Parmar, Anna L. Goodman, Jonathan Badrock, Adam Gregory, Giota Touloumi, Vicky Gioukari, Joseph Lutaakome, Cissy M. Kityo, Francis Kiweewa, Paul Klekotka, Karen Price, Ajay Nirula, Anu Osinusi, Huyen Cao, Amanda Kubernac, Bhakti Patel, Kenneth Smith, Robert Kubernac, Norman P. Gerry, Marie L. Hoover, Craig Brown, Nadine DuChateau, Adam Flosi, Les Johnson, Amy Treagus, Christine Wenner
Journal: Annals of Internal Medicine (2021)

In a randomized, placebo-controlled, clinical trial, bamlanivimab, a SARS-CoV-2-neutralizing monoclonal antibody, given in combination with remdesivir, did not improve outcomes among hospitalized patients with COVID-19 based on an early futility assessment.