tbuckley/cabot-search huggingface dataset:
Desulfurization of Gasoline
Authors: Jerry E. Berger
Journal: Environmental Health Perspectives (1975)

Although gasoline blending streams exhibit widely varying sulfur concentrations, significant quantities of low-sulfur motor gasoline cannot be manufactured by reallocation of existing components without substantial sacrifices in the useful properties of the remaining fuels having normal sulfur levels. To meet the anticipated demand for low-sulfur unleaded gasoline which may be required for catalyst-equipped automobiles it will be necessary to install process equipment based on known hydrotreating technology. The effects which this construction program would exert on the activities, abilities and needs of one petroleum refiner are sketched for two degrees of sulfur removal. The impacts of installing the process facilities which would be necessary are discussed in terms of time requirements, capital needs, and added energy expenditures.
TUMOR MODELS (IN VIVO/IN VITRO)
Authors: E. Brognaro, S. Chang, J. Cha, K. Choi, C. Choi, J. DePetro, C. Binding, M. Blough, J. Kelly, S. Lawn, J. Chan, S. Weiss, G. Cairncross, A. Eisenbeis, R. Goldbrunner, M. Timmer, K. Gabrusiewicz, N. Cortes-Santiago, X. Fan, M. B. Hossain, B. Kaminska, A. Heimberger, G. Rao, W. K. A. Yung, F. Marini, J. Fueyo, C. Gomez-Manzano, B. Halle, E. Marcusson, C. Aaberg-Jessen, S. S. Jensen, M. Meyer, M. K. Schulz, C. Andersen, None Bjarne, W. Kristensen, R. Hashizume, Y. Ihara, T. Ozawa, A. Parsa, J. Clarke, N. Butowski, M. Prados, A. Perry, M. McDermott, D. James, R. Jensen, D. Gillespie, T. Martens, M. Zamykal, M. Westphal, K. Lamszus, E. Monsalves, S. Jalali, T. Tateno, S. Ezzat, G. Zadeh, M. K. Nedergaard, K. Kristoffersen, H. S. Poulsen, M.-T. Stockhausen, U. Lassen, A. Kjaer, F. Ohka, A. Natsume, H. Zong, C. Liu, A. Hatanaka, K. Katsushima, K. Shinjo, T. Wakabayashi, Y. Kondo, K. Picotte, L. Li, B. Westerhuis, H. Zhao, S. Plotkin, M. James, M. Kalamarides, W.-n. Zhao, J. Kim, A. Stemmer-Rachamimov, S. Haggarty, J. Gusella, V. Ramesh, F. Nunes, G. Rao, T. Doucette, Y. Yang, G. Fuller, A. Rao, N. O. Schmidt, N. Humke, H. Meissner, F.-J. Mueller, M. Westphal, O. Schnell, I. Jaehnert, V. Albrecht, P. Fu, J.-C. Tonn, C. Schichor, G. Shackleford, K. Swanson, X.-H. Shi, M. D'Apuzzo, I. Gonzalez-Gomez, R. Sposto, R. Seeger, A. Erdreich-Epstein, R. Moats, R. W. Sirianni, J. M. Heffernan, D. J. Overstreet, L. Sleire, B. S. Skeie, I. A. Netland, J. Heggdal, P.-H. Pedersen, P. O. Enger, C. Stiles, Y. Sun, S. Mehta, C. Taylor, J. Alberta, T. Sundstrom, I. Wendelbo, I. Daphu, E. Hodneland, A. Lundervold, H. Immervoll, K. O. Skaftnesmo, M. Babic, P. Jendelova, E. Sykova, M. Lund-Johansen, R. Bjerkvig, F. Thorsen, M. Synowitz, M.-C. Ku, S. A. Wolf, D. Respondek, V. Matyash, A. Pohlmann, S. Waiczies, H. Waiczies, T. Niendorf, R. Glass, H. Kettenmann, N. Thompson, D. Elder, K. Hopkins, V. Iyer, N. Cohen, J. Tavare, F. Thorsen, B. Fite, L. M. Mahakian, J. W. Seo, S. Qin, V. Harrison, T. Sundstrom, P. N. Harter, S. Johnson, E. Ingham, C. Caskey, T. Meade, K. O. Skaftnesmo, K. W. Ferrara, B. R. Tschida, A. R. Lowy, C. A. Marek, T. Ringstrom, T. J. Beadnell, S. M. Wiesner, D. A. Largaespada, C. Wenger, P. C. Miranda, A. Mekonnen, R. Salvador, P. Basser, J. Yoon, H. Shin, K. Choi, C. Choi
Journal: Neuro-Oncology (2013)
A homemade endoscopic guillotine strikes again: removal of a nasogastric tube mysteriously knotted in the proximal third of the esophagus
Authors: Fabio Pinto do Couto, Aurélie Cavin, Olivier Pittet, Paraskevi Archanioti, Sébastien Godat, Domenico Galasso
Journal: Endoscopy (2022)

A 63-year-old woman with a past history of gastric bypass a few years ago was referred to our hospital with a mechanical ileus. A 14-Fr Salem nasogastric tube (NGT) was already in place for abdominal decompression at the time of admission. An ileal resection including a Meckel’s diverticulum was performed with an ileoileal laterolateral mechanical anastomosis. Postoperatively NGT removal was impossible owing to strong resistance and the patient experiencing thoracic pain. A chest radiograph ([Fig. 1]) and an upper gastrointestinal endoscopy ([Fig. 2 a]) showed coiling of the distal end of the tube, which had formed a knot in the proximal esophagus. Endoscopic removal of the NGT was attempted with the patient under general anesthesia. The NGT knot was pushed down into the gastric pouch to give more space for endoscopic maneuvers but, despite this, the knot could not be untied.
Interpreting Weight, Height, and Body Mass Index Percentiles in the US Centers for Disease Control and Prevention Growth Charts—Reply
Authors: Marissa A. Hendrickson, Michael B. Pitt
Journal: JAMA Pediatrics (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Nearly half reported hepatic adverse drug reactions are unrelated to incriminated drug
Journal: BMJ (1999)

Alcohol lowers risk of heart disease through effect on lipids and haemostatic factors Results from observational studies provide strong evidence that people who drink moderate amounts of alcohol have a lower risk of developing coronary heart disease than those who abstain, but some have suggested that this association is spurious.Rimm et al (p 1523) conducted a meta-analysis of all experimental studies of alcohol intake to summarise the effects of alcohol on lipid and haemostatic factors and to explain the inverse association between alcohol intake and risk of coronary disease.With an alcohol intake of 30 g a day the authors project a 24.7% reduction in risk of coronary heart disease mediated through changes in concentrations of high density lipoprotein cholesterol, fibrinogen, and triglyceride.
CD103 and Intratumoral Immune Response in Breast Cancer
Authors: Zhi-Qiang Wang, Katy Milne, Heather Derocher, John R. Webb, Brad H. Nelson, Peter H. Watson
Journal: Clinical Cancer Research (2016)

CD103 is expressed in several immune cell types but in the context of the intratumoral immune response may be most important as a marker of antigen-activated CD8 T cells.We have examined the prognostic significance of CD103 TILs in breast cancer by IHC in a cohort of 424 breast cancer patients.CD103 TILs were present in all subtypes but were more abundant in ER-negative tumors where CD103 TILs were preferentially localized to the intraepithelial compartment. CD103 was associated with tumor size, tumor grade, and ER/PR status (P < 0.05). CD103 TIL density and the epithelial to stromal ratio was highest in the basal-like tumors. Intraepithelial CD103 but not intrastromal CD103 was associated with better relapse-free and overall survival in basal-like subtype tumors [HR = 0.28; 95% confidence interval (CI), 0.17-0.72; P = 0.0047 and HR = 0.25; 95% CI, 0.17-0.66; P = 0.0017, respectively). CD8 status showed similar but less significant associations, but the combination of dual CD103+CD8+ TIL status was the most strongly prognostic combination for relapse-free and overall survival (HR = 0.10; 95% CI, 0.07-0.62; P = 0.006 and HR = 0.09; 95% CI, 0.07-0.57; P = 0.003, respectively).CD103 TILs are indicative of a good prognosis specifically within the basal-like subtype of breast cancer. Clin Cancer Res; 22(24); 6290-7. ©2016 AACR.
Guy's Hospital
Authors: J. Birkett
Journal: BMJ (1858)

The patient went on wvell for the next two days, but on the l 20th the scrotuin loolked red and swollen.This was the comn- inencement of an erysipelatous attack, followed by an ab- scess in the cellular tissue, at the lower and back part of the scrotum, which was opened by a free incision on the 25th.The wvound of the operation was still open.He was ordered to talke wvine andl diffusible stimulants.The skin of the scroturn slotifflged to a considerable extent, leaving the testicle exposed.Hle was r-ather weak, but went on well till February 13th, wlhen secondary hiuimorrhage came on, and he lost about a pint of blood before it was discovered.As the bleeding vessel could not be found olu the surface, an incision was made, extend- ing from about anl in-chi below the wound of the operation into the out mlade to open the abscess.The principal artery which was bleedin, was in the cord, abouit an inch from the testicle.This was tied, and another vessel was found bleeding in the sloughy tissue of the scrotum.This would not hold a liaature, and was tlherefore treated with the actual cautery, under chloroform.Thlie hbemorrhagre did not recur; and as soon as the slouglhing process had entirely ceased (February 24tlh), the edges of the lIlaps of the scrotum were pared, and brought together with sutures over the testicle.They united by the first intention in a considerable part of their extent; and, on MIarch 3rd, the remainder of the edg-es were ag,ain united, ex- cept a small part whieli was left to form an exit for the pus whiclh vas still coming, from the wounid made for openingc, the abscess.This latter proceeding, however, did not succeed; but the wound is now filling up by granulations, and the man gets about the ward, and is convalescent.REMAPKS.The hLmo-rhage in this case appears to have teen due to ulceration, the consequence of sloughing in the oinelntmiuni, Which hald beenl attached to the cord, or to the in- flammnrlation set ul) by thie operation.The fact that the testicle did not become atrophied shows that the vessel wlhich was tied in the cord could inot have been the trunik of the spermatic artery; but, froem its size and position, it seemed impossible that it could lhave been oTne of the small branclhes supplied to its coverings.It is prlobable, therefore, that in this case the spermatic artery (as it very often does) bifurcated before ie-aching the testicle; aud thlat, therefore, after the ligature, a vessel remained capable of carrying on the nutrition of the gland.The plastic operation for expediting the covering of the testicle, atter its exposuire by the sloughing, was so far suc- cessftul that no doubt now remains on that point, and the man m-ay be regarded as beyond the danger of any further sloughing.
"Painless" Intussusception
Authors: R. P. Cumming
Journal: BMJ (1962)

MEDICAL JOURNALwith typical large cosinophilic cytoplasmic inclusions, while the intervening placental tissue was normal.Scrapings from one of the skin lesions, when cultured on the allantoic membrane of developing chick embryos, grew vaccinia virus.COMMENT The appearance of the foetus and its weight suggest that death had probably occurred rather later than the date of cessation of movements would indicate.While nobody would dispute the overriding need for protection against smallpox in all contacts, this case demonstrates that the foetus is at risk from maternal vaccinia in mid-term.It is not an isolated example, for similar cases have been reported by Wielenga et al. (1961), Lynch (1932), MacDonald andMacArthur (1955), andWiersum (1956).There are probably others that have not been recorded.
Methaqualone.
Authors: R. De Alarcon
Journal: BMJ (1969)

JOUNiALinstances gave rise to suicidal attempts.It was always relieved by discontinuing the drug.A mild, ephemeral depression was also observed in several other patients.The disproportionately high incidence of side-effects as compared with psychotic relapses is very striking.While many of these were undoubtedly due to early inexperience in managing doses, and time intervals between injections, it was felt that they were a considerable obstacle to the widespread accept- ance of the drug.We found that acute side- effects generally responded to intravenous pro- cyclidine hydrochloride (Kemadrin), and this treatment is always available at the outpatient department in the hospital; benzhexol (Artane) is used for more chronic Parkinsonian side- effects, and promethazine hydrochloride (Phenergan) for akathisia.It is important to recognize side-effects before these give rise to serious disabilities and possibly hospital admission.We are presently trying out a newer preparation, fluphenazine decanoate (Modecate), reported to give fewer adverse effects.
Abstract 02: Association Between Hospital Volume of Cardiopulmonary Resuscitation for In-Hospital Cardiac Arrest and Survival to Hospital Discharge
Authors: Emmanuel O Akintoye, Ando Tomo, Oluwole Adegbala, Adedotun Alade, Alexandros Briasoulis, Alexander Egbe, Luis Afonso
Journal: Circulation (2018)

Background: Prior studies have shown that hospital case volume is not associated with survival in patients with out-of-hospital cardiac arrest (OHCA). However, how case volume impact on survival for in-hospital cardiac arrest (IHCA) is unknown Methods: We queried the National Inpatient Sample (NIS) in the U.S. 2005-2011 to identify cases in which in-hospital CPR was performed for IHCA. Years &gt; 2011 were excluded due to redesign of NIS that precludes case volume calculation. Restricted cubic spine was used to evaluate the association between hospital annual CPR volume and survival to hospital discharge. Further analysis was conducted with case volume in quartiles. Results: Across more than 1000 hospitals in NIS, we identified 137,466 cases (mean age 67, 45% female) of IHCA for which CPR was performed over the study period. Median [Q1, Q3] case volume was 68 [34, 100]. Compared to those in the 1 st quartile (q1) of case volume, hospitals in the 4 th quartile (q4) tends to have younger patients (mean=66 vs 68 yrs), higher comorbidities (median Elixhauser score=4 vs 3), large bed size (89 vs 37%), and in low income areas (37 vs 32%). After adjustment for patient and hospital factors, higher hospital case volume was inversely associated with lower rates of survival (Fig1). Risk-adjusted rates of survival from q1 through q4 were: 28.1%, 25.5%, 25.4% and 23.7%. We arrived at similar results when analysis was stratified by age, gender and hospital bed size (not shown) except that the difference across quartiles was more pronounced among small bed size hospitals (survival rate=27.4% in q1 vs 8.1% in q4). However, among those who survived to hospital discharge, nonroutine home discharge was higher among patients in q1 (73.9%) vs q4 (69.6%) Conclusion: Unlike OHCA, hospital case volume is inversely associated with survival to hospital discharge in patients undergoing CPR for IHCA. Hence, quality measures to reduce the incidence of CPR/IHCA have the potential to reduce in-hospital mortality
Surgical Anatomy and Physiology
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Significance of the Rh Factor -- II
Authors: K. E. Boorman, B. E. Dodd, P. L. Mollison
Journal: BMJ (1942)

MEDICALJOURNAL 569 vascular disease.The healthiest doctors at the age of 65 have had a similar family history of cardiovascular disease, and much the same may be said of those who develop pulmonary tuberculosis; my inference is that the same experience would be found in the same number of doctors suffering from other diseases.Also, it can be generally stated that the medical men who develop pulmonary tuberculosis between the ages of 30 and 65 have no worse tuberculous family history than the healthiest doctors, nor indeed than those who develop coronary thrombosis.I believe the converse is true: that a family history of tuberculosis is negligible after the age of 30, and even before that age.,Onset of Coronary Thrombosis.-The records were then searched to find at what ages coronary thrombosis occurred, how many died of this illness, how many survived and were unfit to work again, and how long those worked who com- pleted their convalescence. Ages at Onset
St. Mary's Hospital
Authors: C. H. Jones
Journal: BMJ (1862)

THE following observations have reference chiefly to the pathology and treatment of skin-diseases, which ought certainly to be the main objects of our attention, rather than the arrangement and grouping of these affections according to minute distinctions.Among 1500 cases of all kinds taken indiscriminately, and chiefly from the out-patients of St. Mary's Hospital, there were 142 cases of skin-diseases, exclusive of sy- philitic.Of these, eczema numbers 38, impetigo 7, psoriasis 24, lichen 23, pemphigus 4, acne 4, lupoid dis- ease 4, prurigo '2, pruritus 4, herpes zoster 5, parasitic disease 0, alopecia areata 3, purpura 3, pityriasis 2; while there remain ten cases of various other affections.Of course, a very much larger number of cases of skin- diseases have been treated, of which, for various reasons, it was not thought worth while to preserve a record.These have been chiefly the cases of eczema or impetigo, so common among children.The proportion of skin-diseases to other disorders is not, however, disturbed by their omission, as a vast number of other cases of all kinds have been similarly omitted.The following table shows the influence of sex.M. F.
Association between CD47 expression and clinicopathologic characteristics and survival outcomes in MIBC.
Authors: Zin Myint, Rani Jayswal, Zena Chahine, Sara E Bachert, Robert J McDonald, Derek B. Allison
Journal: Journal of Clinical Oncology (2022)

534 Background: CD47 is an antiphagocytic molecule that plays a critical role in immune surveillance. A variety of malignancies have been shown to evade the immune system by increasing the expression of CD47 on the cell surface. As a result, anti-CD47 therapy is under clinical investigation for these. CD47 overexpression is associated with negative clinical outcomes in lung and gastric cancers; however, the expression and functional significance of CD47 in bladder cancer is not fully understood. Methods: We retrospectively studied patients with muscle invasion bladder cancer (MIBC) on transurethral resection of bladder tumor (TURBT) who subsequently underwent radical cystectomy (RC) with or without neoadjuvant chemotherapy (NAC). CD47 expression was examined by immunohistochemistry in both TURBT and matched RC specimens. Expression levels ≥1% were considered positive. The difference between CD47 expression levels between TURBT and RC were also compared. The association of CD47 levels (TURBT) with clinicopathological parameters and survival outcomes were evaluated by Person’s chi-squared test and Kaplan-Meier method respectively. Results: A total of 87 MIBC patients were included. The median age was 66 (39-84) years. The majority of patients were Caucasian (95%), male (79%), and age &gt; 60 (63%). Most patients (75%) underwent NAC prior to RC. Of those who received NAC, 35% were responders and 64% were non-responders. Responders includes those with a pathologic complete response (T0) or partial response (Tis or T1); non-responders included those with stage ≥ T2. The final reported stages for all patients were as follows: stage 0 (32%), stage I (1%), stage II (20%), stage III (43%), and stage IVA (5%). 60% of patients were alive, 40% died from bladder cancer, and 30% had disease recurrence at a median follow-up of 3.1 (0.2-14.2) years. CD47 levels were detectable in 38 (44%) TURBT samples. There was no association between CD47 levels and clinicopathological parameters such as age, gender, race, NAC, final stage, disease recurrence, and overall survival (OS). Patients &gt; 60 (p = 0.006), non-responders (p = 0.002), stage ≥ III (p &lt; 0.001) were associated with worse OS by univariate analysis. There was no significance with multivariate analysis. There was a slight positive trend for decreased CD47 levels between TURBT and RC in patients who received NAC (p = 0.5), though this did not reach statistical significance. Conclusions: CD47 expression is not a prognostic marker for MIBC patients. However, expression of CD47 was detected in nearly half of MIBCs, and future studies are needed to explore a potential role for anti-CD47 therapy in these patients. Furthermore, there was a slight positive trend between decreased CD47 levels (from TURBT to RC) in patients receiving NAC. More research is needed to understand how NAC may or may not modify immune surveillance mechanisms in MIBC.
Pre-Existing Autoimmune Disease and Mortality in Patients Treated with Anti-PD-1 and Anti-PD-L1 Therapy
Authors: Kimberly Tang, Bruce C Tiu, Guihong Wan, Shijia Zhang, Nga Nguyen, Bonnie Leung, Alexander Gusev, Kerry L Reynolds, Shawn G Kwatra, Yevgeniy R Semenov
Journal: JNCI Journal of the National Cancer Institute (2022)

Although indications for immune checkpoint inhibitors (ICIs) have dramatically increased in the past decade, ICIs have been associated with autoinflammatory immune-related adverse events, which can resemble autoimmune diseases (ADs). Little is known about the impact of baseline AD on mortality in cancer patients treated with ICIs. Here, we identified 17 497 patients with preexisting autoimmune diagnoses prior to treatment with antiprogrammed cell death receptor-1 or antiprogrammed cell death ligand-1 therapy and 17 497 matched controls through the TriNetX Diamond network of more than 200 million patients across the United States and Europe. Using a Cox proportional hazards model, we found that patients with history of AD were not at higher risk of mortality than non-AD patients (hazard ratio [HR] = 1.03, 95% confidence interval [CI] = 1 to 1.07; P = .05). Additionally, history of Hashimoto disease (HR = 0.75, 95% CI = 0.62 to 0.90; P = .002) and vitiligo (HR = 0.52, 95% CI = 0.34 to 0.81; P = .003) were statistically significantly associated with decreased mortality. This suggests that underlying AD need not be a contraindication to inclusion in clinical trials and administration of ICI for treatment of cancer.