tbuckley/cabot-search huggingface dataset:
Homosexuality in Males with Particular Reference to Marriage
Authors: K. Imielinski
Journal: Psychotherapy and Psychosomatics (1969)

Research Articles| February 12 2010 Homosexuality in Males with Particular Reference to Marriage Subject Area: Psychiatry and Psychology K. Imielinski K. Imielinski Section of Sexuology, Department of Motherhood Welfare, Research Institute of Mother and Child Health, Warsaw, Poland (Head of the Department: Prof. Dr. I. Roszkowski) Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1969) 17 (2): 126–132. https://doi.org/10.1159/000286022 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation K. Imielinski; Homosexuality in Males with Particular Reference to Marriage. Psychother Psychosom 1 February 1969; 17 (2): 126–132. https://doi.org/10.1159/000286022 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search This content is only available via PDF. 1969Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
The use or uselessness of annual public health reports
Authors: A. Davies, A Rouse
Journal: BMJ (1998)

Editor—I scarcely recognise my paper Reporting the Public Health from reading Scally’s editorial.1,2 I do not argue for centralisation of funding, merely that the budget for the production and dissemination of annual reports should be administered, and thereby ring fenced as a protected public health function, by the minister for public health. This could elevate the exercise in those authorities where it has often been done on the cheap with little attention to impact. It would also prevent any further merging of annual public health reports with those of health authorities. In other words, it would safeguard their independence. 

Scally is therefore wrong to suggest that the net effect of several of my recommendations would be to reduce the independence of the public health report. The whole thrust of my report is towards a more independent public health function. In arguing for reorganisation of the public health infrastructure (with some prescience, as it turns out) I propose a distinct pyramidal structure independent of the NHS Executive whose “ethos would be one of independence to monitor and publicly criticise not only Department of Health policies, as implemented by health authorities, but any area of policy which has a bearing on health.” 

In commenting on the least substantial of my recommendations (that the reports could be published every two or three years instead of annually) Scally suggests that there is no shortage of public health issues to be tackled and that annual reports can and should be a catalyst to action. That is my point exactly. I propose low cost annual statistical updates and two or three yearly in depth reports yielding a minimum set of comparable data relevant to national policy initiatives, such as a strategy to tackle health inequalities. This is far from being the “greater government specification of content” which Scally sees as constraining. It would simply enable annual reports to be a tool for monitoring progress towards agreed targets appropriate to local populations. Directors of public health should be free to report on any issue they consider relevant to the public health, and I also propose designating the director of public health with the lead role in developing local, multisectoral strategies for health.
Variant Genotypes of the Low-Affinity Fcγ Receptors in Two Control Populations and a Review of Low-Affinity Fcγ Receptor Polymorphisms in Control and Disease Populations
Authors: Thomas Lehrnbecher, Charles B. Foster, Shaoxian Zhu, Susan F. Leitman, Lynn R. Goldin, Konrad Huppi, Stephen J. Chanock
Journal: Blood (1999)
United Kingdom prospective diabetes study
Authors: B. M Margetts
Journal: BMJ (1995)

Relation between various factors and response to mammographic screening 1991-2 Did not respond Responded Characteristic (n=34) (n=217) Age range (average) (years) 52-65 (57) 50-65 (57) Non-response for cervical screening 20** 16** Not known personally to general practitioner 22* 77* Marital status: Married 24 176 Widowed 5 29 Divorced 4 5 Single 1 7 *P=0*01, **P=0 001.ascertained whether the following factors were associated with non-attendance: non-response for cervical screening, marital status, and whether the patient had personal knowledge of the general practitioner.The only factors that reached signifi- cance (table) were non-attendance for cervical screening (P< 0 001) and no personal knowledge of the general practitioner (P < 001)).
Vocational rehabilitation
Authors: G. Paschkes-Bell, J. Leach, I. McCurdie, N. Carter
Journal: BMJ (2001)

Nodular thyroid disease Abnormal thyroid function may be positive discriminator for malignancyEditor-Keston Jones states that testing of thyroid function is still one of the cornerstones of investigation in nodular thyroid disease. 1 He also states that overt thyroid dysfunction effectively rules out the possibility of malignancy.Thyroid function tests will not help in the discrimination of a nodule as they give no description of the nodule.In addition, malignancy may occur in patients with hyperthyroidism and a palpable thyroid nodule.Kraimps et al report that in patients with a cold nodule and Graves' disease the incidence of malignancy is as high as 15%, and that malignancy should be taken as an indication for total thyroidectomy, although in this group the nodules were mainly nonpalpable. 2ore impressively, Carnell and Valente report that 19% of palpable cold nodules were malignant in a retrospective review of 468 patients with Graves' disease. 3Thus in some instances abnormal thyroid function seems to be a positive discriminator for malignancy, although in the most euthyroid patients it will give no further diagnostic information.
Abstract 8115: Circadian Rhythm Pattern of Events in Tako-tsubo Cardiomyopathy
Authors: Scott W Sharkey, Victoria R Pink, John R Lesser, Ross F Garberich, Martin S Maron, Barry J Maron
Journal: Circulation (2011)

Background. Tako-tsubo cardiomyopathy (TTC) is an acute reversible cardiac condition, usually triggered by stressful events, with predilection for older women and a distinctive left ventricular contraction profile. Definition of the diurnal hourly pattern of TTC events may contribute to our understanding of the pathogenesis of this complex entity, but is presently unresolved. Methods. We prospectively enrolled 186 consecutive TTC patients at the Minneapolis Heart Institute and (for comparison) 2,975 patients with ST-segment myocardial infarction (STEMI) over the same time period. Circadian periodicity was analyzed for hourly occurrence of events throughout the 24-hour day, in 4-hour interval blocks. Results. In TTC, the hourly occurrence of events was not uniformly distributed, but showed a distinct and statistically significant afternoon peak between 12:00 pm (noon) and 4:00 pm, comprising 28% of all TTC events, with a nadir at 12 am - 4 am (chi-square = 25.6; p &lt; 0.001), and uninfluenced by age (Figure 1). In contrast, STEMI patients showed a peak occurrence in the early morning hours, 8:00 am to 12:00 noon, comprising 24% of all events (chi-square = 248; p &lt; 0.001), and consistent with prior literature in coronary artery disease. While TTC patients were predominantly female (i.e., 95%), men and women with STEMI showed no difference in circadian pattern. Conclusions. Circadian rhythm of TTC events showed a novel peak in the afternoon hours, distinctive from the STEMI pattern. This hourly timing of TCC events is consistent with environmental factors (i.e., stressful life situations) as the trigger for this condition.
Abstract 2693: An Inflammatory Paradox in Acute Respiratory Distress Syndrome? Plasma C-reactive Protein Concentrations are Strongly Associated with Survival in ARDS
Authors: James L Januzzi, Ednan Bajwa, Uzma Khah, Michelle Gong, B. T Thompson, David Christiani
Journal: Circulation (2008)

C-reactive protein (CRP) is a marker of systemic inflammation, and potently predicts adverse outcome in a number of diseases, but little is known about its characteristics in Acute Respiratory Distress Syndrome (ARDS). Experimental data suggest CRP may play a protective role in alveolitis; clinical correlates are lacking. We measured CRP in 177 patients within 48 hours of ARDS onset and tested the association of protein level with 60-day mortality, 28-day daily organ dysfunction scores, and number of ventilator-free days. CRP was significantly lower in non-survivors when compared with survivors (176.5 [IQR 173.0] vs.133.5 [IQR 161.0] mg/L; P = .02). Mortality rate decreased with increasing C-reactive protein decile ( P = .02). After adjustment for age, APACHE score, and relevant covariates in a multivariable model, plasma CRP concentrations independently and potently predicted survival in ARDS (Hazard ratio=0.996; P = .009). When stratified into groups by higher or lower CRP level, patients with CRP had significantly higher probability of survival at 60 days ( P = .005). Also, patients with higher CRP levels had lower organ dysfunction scores ( P = .001) and more ventilator-free days ( P = .02). Consistent with experimental data suggesting a possible protective role of CRP in experimental alveolitis, higher plasma levels of CRP within 48 hours of ARDS are associated with improved survival, lower organ failure scores, and fewer days of mechanical ventilation. These data appear to be contrary to the established view of CRP solely as a non-specific marker of systemic inflammation, and raise the potential for a therapeutic role for CRP in ARDS.
Abstract 281: Initial Illness Severity Not Hypothermia Treatment is Associated With Outcome After Cardiac Arrest
Authors: Jon C Rittenberger, Margo B Holm, Francis X Guyette, Samuel Tisherman, Clifton W Callaway
Journal: Circulation (2010)

Background: The effect of illness severity on response to therapeutic interventions for cardiac arrest such as therapeutic hypothermia (TH) is unknown. This study examined the effects of TH on surv...
Chemotherapy for advanced colorectal cancer : Please aim for accuracy rather than hard hitting headlines
Authors: Magdi M Kirollos
Journal: BMJ (2001)

Editor—Michael and Zalcberg's editorial on chemotherapy for advanced colorectal cancer and the Colorectal Cancer Collaborative Group's systematic review of palliative chemotherapy for advanced colorectal cancer agree superficially.1,2 This makes the discrepancy between their conclusions surprising and raises certain questions of accuracy and presentation. The editorial overplays the value of such treatment, which was more scientifically assessed by the paper.

Firstly, the editorial's statement that there is a 35% reduction in the risk of death for treated patients is an oversimplification of the results. In the systematic review, from which this conclusion was derived, fig 2 unambiguously shows that the risk of death is only about 16% less in the treated group.2 This translates to a median survival advantage of only four months and applies only to a period between 5 and 15 months from the start of treatment. This summary is more accurate than the one derived from the more complicated and inferred statistics used in the editorial.

Secondly, the editorial tries to make a case for a palliative value of the treatment where the paper fails to find such a benefit. It makes that case for two subgroups of patients in single studies (references 4, 5, 6 in the editorial corresponding to references 15, 22, 17 in the paper). The result of this “splitting” contradicts the overall result in the paper: “data on the effect of chemotherapy on quality of life are inadequate to draw firm conclusions about the palliative benefit of chemotherapy.”

Thirdly, the editorial glosses over the toxicity of chemotherapy, which could not be meaningfully summarised in the systematic review.2 Additionally, the literature possibly underestimates the toxicity of chemotherapy in view of the relatively younger population of the reviewed studies.

The editorial lacks the expected balance of opinion. The impact of an editorial with a gripping headline in a journal such as the BMJ should be more seriously considered. The now freely available access to such an unbalanced message can lead to conflict between a terminally ill and vulnerable group of patients and their medical carers, resulting in unnecessary suffering and a possible break of trust.
Abstract 1301: NFATc- And SRF-induced Early Growth Response (Egr)-3 Is Essential For VEGF-mediated Endothelial Cell Migration And Tube Formation
Authors: Jun-ichi Suehiro, Mai Miura, Tatsuhiko Kodama, Takashi Minami
Journal: Circulation (2007)

Endothelium is a dynamic cell layer constantly responding to changes in the various extracellular mediators. Responses are usually beneficial to host, but oversustained or dysregulated responses can result in vascular dysfunction, leading to the initiation of atherosclerosis, tumor growth, and inflammation. Such endothelial cell activation and dysfunction are mediated in large part by alterations in gene expression. Here we show, using comprehensive transcriptome analyses, that VEGF, thrombin and TNF-α each induces a dramatic and rapid up-regulation of early growth response (Egr)-3 in human umbilical vein endothelial cells (HUVEC). The effect of VEGF on Egr-3 was similar in human coronary artery, pulmonary artery, and dermal microvascular endothelial cells. In chemical inhibitor studies, VEGF-mediated induction of Egr-3 (mRNA peak 300-fold at 45 min) depended on MEK1/2, JNK, PI3K, PKA, and Ca-calcineurin. Egr-3 promoter luciferase and electrophoretic mobility shift analysis revealed that the 5′-flanking region at −57 to −130 was necessary and sufficient for transducing of VEGF-mediated Egr-3 upregulation and that region could bind NFATc1, c2, and SRF. Co-transfection assays with Egr-3 reporter and either NFATc or SRF expression plasmids resulted in 4 and 2 -fold Egr-3 promoter activation, respectively. In DNA microarray studies, HUVEC treated with VEGF for 1 and 4 hours in the presence of two independent siRNAs against Egr-3, 25 and 70 VEGF-inducible genes were strikingly downregulated, respectively. The pro-angiogenesis factors Ets-1, CXCL1, and tissue factor were among those genes downregu-lated. SiRNA knockdown of Egr-3 markedly impaired VEGF-mediated cell migration and tube formation, as determined by in vitro wound healing, boyden chamber, and collagen gel assays. Moreover in aortic ring assays, VEGF-stimulated neo-angiogenesis from the extracted mice aorta was completely abolished by administration of adenoviral-transferred miRNA against Egr-3. Collectively, these findings suggest that NFATc and SRF cooperatively upregulate Egr-3. Egr-3 might have an important function as a signal transducer in VEGF-mediated angiogenesis in activated endothelium.
Differential Association of Insulin Resistance and Metabolic Syndrome With Acute Myocardial Infarction and All-Cause Mortality in Older Adults
Authors: Ravi V Desai, Prakash Deedwania, Mustafa I Ahmed, Marjan Mujib, Yan Zhang, Wilbert S Aronow, Gregg Fonarow, Ali Ahmed
Journal: Circulation (2010)

Background: Insulin resistance (IR) and metabolic syndrome (MetS) often coexist and both are considered risk factors for adverse cardiovascular (CV) outcomes. However, recent evidence suggests the ...
Abstract 16727: A First Description of Increased Glutaminolysis in Experimental Right Ventricular Hypertrophy; Association With Ischemia-Induced Activation of cMyc
Authors: Lin Piao, Yong-Hu Fang, Kishan Parikh, Peter T Toth, Glenn Marsboom, Stephen L Archer
Journal: Circulation (2011)

INTRODUCTION We have previously showed that in right ventricular hypertrophy (RVH) and RV failure there is a maladaptive metabolic switch from glucose oxidation to glycolysis. A similar metabolic shift occurs in many cancers. Another metabolic derangement in cancer that is a metabolic shift to use glutamine as a substrate, glutaminolysis, has not been studied in RVH. cMyc, an oncogenic transcription factor, cooperating with hypoxia-induced factor 1, induces both glycolysis and glutaminolysis in cancer cells. We hypothesized that cMyc activation induces glutaminolysis in RVH. METHODS AND RESULTS 3 groups of Sprague-Dawley rats were studied: 1) Control; 2) Pulmonary artery banding (PAB), in which RVH is induced by a 1.3mm pulmonary artery band; 3) Monocrotaline-induced RVH, elicited by subcutaneous injection of monocrotaline (60mg/Kg). RVH occurred with PAB and monocrotaline, evident from increased RV/LV+septum ( P &lt;0.001 vs control). In an RV Langendorff model, total coronary flow collected from coronary sinus was reduced in PAB and monocrotaline models vs control ( P &lt;0.01). Staining for CD31 and lectin (both markers of endothelial cells) demonstrated that capillary density was reduced in both RVH models vs control ( P &lt;0.05). The RV in monocrotaline model had lower capillary densities than RV in PAB model ( P &lt;0.05). cMyc expression was significantly increased in RV in both RVH models ( P &lt;0.05 vs control). cMyc also was increased in LV in monocrotaline model ( P &lt;0.05 vs control) but was unchanged in LV in PAB model. mRNA expression of the glutamine transporters, SLC7A5 and SLC1A5, were increased in both RV and LV in monocrotaline RVH ( P &lt;0.05 vs control); whereas only SLC7A5 expression was elevated in PAB RVs ( P &lt;0.05 vs control). CONCLUSION There is an increase of glutaminolysis in RV in RVH models. This is associated with RV ischemia and capillary rarefaction. It is unclear whether the observed cMyc activation is caused by or induces the capillary rarefaction. However, it is likely cMyc accounts for the increased glutaminolysis which is a newly recognized metabolic abnormality in RVH models. Our study suggests the potential of therapeutic inhibition of glutaminolysis as a treatment for RVH and RV failure.
Abstract 10299: Influence of Diabetes Mellitus on the Presentation Symptoms and In-hospital Outcomes of Patients With Atrial Fibrillation: From a 20-year Registry
Authors: Amar M Salam, Hajar AlBinali, Rajvir Singh, Awad Al-Qahtani, Nidal Asaad, Jassim Al Suwaidi
Journal: Circulation (2013)

Objectives: The aim of this study was to identify whether patients with Diabetes Mellitus (DM) have different presentation symptoms and in-hospital outcome compared to non-diabetic patients when pr...
Abstract 18496: Disruption of Prolyl Hydroxylase-1 Attenuates Ischemia/Reperfusion Injury by Stabilizing HIF-1 Alpha Transcription Factor Followed by Activation of Beta-Catenin/VEGF/Ang-1 and NF-kappaB Signaling in Mice
Authors: Ram Sudheer Adluri, Mahesh Thirunavukkarasu, Nageswara Rao Dunna, Gautam Maulik, Guo-Hua Fong, Nilanjana Maulik
Journal: Circulation (2010)
Abstract 3076: Effects of Exercise on Ventricular Mechanical Dyssynchrony in Patients with Heart Failure Currently not Recommended for Resynchronization - Results from the Dyssynchrony Induced by Ventricular Exertion in Heart Failure (DIVE-HF) Study.
Authors: Yi-Chih Wang, Chih-Chieh Yu, Juey-Jen Hwang, Ling-Ping Lai, Chia-Ti Tsai, Chuen-Den Tseng, Rodolphe P. Katra, Jiunn-Lee Lin
Journal: Circulation (2007)

Background. Resynchronization therapy has been proven to improve exercise tolerance only in heart failure (HF) patients (pts) with profoundly impaired left ventricular ejection fraction (LVEF). Whether it could be useful to other spectrum of HF pts may depend on the existence of ventricular dyssynchrony, either at rest or exercise-induced. Methods. We studied clinical features, ECG, and echocardiography coupled with tissue Doppler imaging (TDI) in 70 pts (38 men and 32 women, mean age 62±13 years). Among them, 60 pts with compensated HF (functional class II–III) for at least 3 months were grouped into systolic HF (SHF; EF=35–50 %, N=30) and diastolic HF (DHF; EF=50 % plus diastolic dysfunction, N=30) groups. The other 10 pts had no systolic or diastolic dysfunction are the control group. Six-minutes (stage 2) treadmill exercise tests were performed for SHF pts by modified Bruce protocol and for DHF and control pts by Bruce protocol. Dyssynchrony index (DI) represented by standard deviation of electromechanical delays of 12 LV segments was measured before and immediately after exercise. Results. Except for diverse clinical features and conventional echo-parameters as expected, the QRS duration was similar (mean: 93±16 ms) between the 3 groups. TDI studies showed that baseline synchronized LV contraction remained unchanged after exercise (DI: 12.4±3.6 vs. 11.8±2.9 ms, p =ns) in control group. With regard to the DHF group, the preexisting ventricular dyssynchrony got significantly exacerbated (DI: 52.4±10.0 vs. 62.4±12.8 ms, p&lt; 0.001) including 21 pts (70%) with a ≥ 10% increase of DI after exercise provocation. With a more complex response to exercise, the DI in SHF pts didn’t worsen significantly (27.0±19.2 vs. 32.8±20.6 ms, p&lt; 0.06). However, the proportion of DI&gt;33 ms, considered as presence of dyssynchrony, increased from 37% at baseline to 50% after exercise, including 6 pts (20%) with post-exercise new development and 2 pts (7%) with post-exercise disappearance of ventricular dyssynchrony. Conclusions. Exercise-exacerbated ventricular dyssynchrony in DHF pts, and a 50% incidence of post-exercise dyssynchrony in SHF pts with LVEF between 35 to 50% may support the potential utility of resynchronization therapy to these non-indicated HF groups.
Azacitidine and Donor Lymphocyte Infusions As Treatment For Relapse After Allogeneic Stem Cell Transplantation - a Retrospective Multicenter Analysis In 115 Patients On Behalf Of The German Cooperative Transplant Study Group
Authors: Thomas Schroeder, Elena Rachlis, Gesine Bug, Matthias Stelljes, Stefan A. Klein, Dominik Wolf, Mark Ringhoffer, Akos G. Czibere, Kathrin Nachtkamp, Ariane Dienst, Mustafa Kondakci, Michael Stadler, Uwe Platzbecker, Lutz Uharek, Thomas Luft, Roland Fenk, Ulrich Germing, Martin Bornhäuser, Nicolaus Kröger, Rainer Haas, Guido Kobbe
Journal: Blood (2013)