tbuckley/cabot-search huggingface dataset:
Abstract 17250: Underestimation of RV Volume by 3D Echocardiography in Patients With Severe PAH
Authors: Saad Kubba, Sophia Airhart, Kelly Wickstrom, Jose Rosado-Toro, Raj Janardhanan, Rebecca Vanderpool, Franz Rischard
Journal: Circulation (2018)

Background: Right ventricular (RV) volume is a significant predictor of mortality in pulmonary arterial hypertension (PAH). RV volume measured by 3D echocardiography (3DE) an attractive imaging modality because it is faster and cheaper than cardiac MRIs. However, newer semi-automated speckle tracking 3DE has not been validated against cardiac MRI (CMR) in patients with severe PAH and dilated RVs. This study investigated the feasibility of 3DE to measure RV volumes in a prevalent cohort of patients with severe PAH. Methods: Patients with severe PAH with a 3DE and CMR within 30 days were included. RV endocardial contours were performed using TomTec 4D RV analysis© for 3DE and Circle Cardiovascular Imaging 42© for CMR. Results: Patients (n = 11) had severe PAH as classified as having high sPAP (66.4±5.0 mmHg), and reduced RV ejection fraction as measured by CMR (37.7±2.9%). In two patients, 3DE was not obtainable due to suboptimal definition of ventricular walls. In the remaining patients, there were systematic underestimation of volumes by 3DE (EDV bias: -71.5 LOA: 63.7; ESV -58.7: LOA: 72.7) and appears to be volume dependent (Fig 1A ). Lack of agreement seemed to possibly be related to extrapolation of poorly defined lateral wall RV endocardium by 3DE in patients with a large right ventricle (Fig 1B). Conclusion: Lack of agreement between CMR and 3DE derived RV volumes suggests the need for further validation of 3DE in patients with severe PAH.
Heparin-binding EGF-like growth factor (HB-EGF) plays a critical role in the EGFR transactivation after angiotensin II stimulation in vascular smooth muscle cells Masanori Asakura, Masafumi Kitakaze, Seiji Takashima, Shigeki Higashiyama, Hiroshi Asanuma, Shoji Sanada, Yasuhiko Sakata, Hisakazu Ogita, Yulin Liao, Toshihiko Toyofuku, Tsunehiko Kuzuya, Michihiko Tada, Masatsugu Hori. Osaka University, Osaka, Japan
Journal: Journal of the American College of Cardiology (2001)
Women do have an increased risk of contrast media-associated nephrotoxicity after coronary angioplasty Christian M�ller, Gerd B�rkle, Heinz J. B�ttner, Andre P. Perruchoud, Helmut Roskamm. Medizinische Universit�tsklinik, Basel, Switzerland, Herz Zentrum, Bad Krozingen, Germany
Journal: Journal of the American College of Cardiology (2001)
Treatment of Progressive Nodular Histiocytosis With Baricitinib
Authors: Yuqi Huang, Zeqiao Zhang, Lei Zhu, Yongfeng Chen
Journal: JAMA Dermatology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Breath of Life: Heart Disease Link to Developmental Hypoxia
Authors: Dino A. Giussani
Journal: Circulation (2021)

Heart disease remains one of the greatest killers. In addition to genetics and traditional lifestyle risk factors, we now understand that adverse conditions during pregnancy can also increase susceptibility to cardiovascular disease in the offspring. Therefore, the mechanisms by which this occurs and possible preventative therapies are of significant contemporary interest to the cardiovascular community. A common suboptimal pregnancy condition is a sustained reduction in fetal oxygenation. Chronic fetal hypoxia results from any pregnancy with increased placental vascular resistance, such as in preeclampsia, placental infection, or maternal obesity. Chronic fetal hypoxia may also arise during pregnancy at high altitude or because of maternal respiratory disease. This article reviews the short- and long-term effects of hypoxia on the fetal cardiovascular system, and the importance of chronic fetal hypoxia in triggering a developmental origin of future heart disease in the adult progeny. The work summarizes evidence derived from human studies as well as from rodent, avian, and ovine models. There is a focus on the discovery of the molecular link between prenatal hypoxia, oxidative stress, and increased cardiovascular risk in adult offspring. Discussion of mitochondria-targeted antioxidant therapy offers potential targets for clinical intervention in human pregnancy complicated by chronic fetal hypoxia.
Point-of-Care Ultrasonography
Authors: José L. Díaz-Gómez, Paul H. Mayo, Seth J. Koenig
Journal: New England Journal of Medicine (2021)

POCUS is performed by the treating clinician at the bedside, with immediate interpretation and clinical integration of the imaging results. This review discusses POCUS technology, clinical applications, and the complementarity of POCUS and consultative ultrasonography in primary imaging specialties.
Efficacy of immune checkpoint inhibitors for gastrointestinal cancers with SWI/SNF complex genetic alterations.
Authors: Akinobu Nakata, Yukiya Narita, Ryosuke Kumanishi, Taiko Nakazawa, Takatsugu Ogata, Yuki Matsubara, Hiroyuki Kodama, Kazunori Honda, Toshiki Masuishi, Hiroya Taniguchi, Shigenori Kadowaki, Masashi Andoh, Rui Yamaguchi, Masahiro Tajika, Kei Muro
Journal: Journal of Clinical Oncology (2022)

346 Background: SWI/SNF chromatin-remodeling complex is encoded by multi-gene families that are recurrently mutated in cancer. Previous studies reported that tumors harboring SWI/SNF complex genetic alterations (GA) are sensitive to immune checkpoint inhibitors (ICIs), but the clinical significance of SWI/SNF complex GA in patients with gastrointestinal cancers (GICs) is unclear. Methods: We reviewed patients with metastatic GICs who underwent comprehensive genomic profiling (CGP) and received ICIs at our institution between July 2014–June 2021. SWI/SNF complex GA were defined as ARID1A, ARID1B, ARID2, PBRM1, SMARCA4, and SMARCB1 alterations. Results: Of 292 patients receiving CGP, 136 patients received ICIs, of which 10 (7.4%) had SWI/SNF GA, including 8 ARID1A (5.9%), 1 ARID2 (0.7%) and 2 SMARCA4 (1.5%) alterations. The subjects included 50 esophageal cancers, 84 gastric cancers, and 2 small intestine cancers. The patients with SWI/SNF complex GA had significantly higher proportions of microsatellite instability-high ( p = 0.004) and lower proportions of esophageal cancer ( p = 0.002), compared with patients without SWI/SNF complex GA. During the median follow-up time of 7.5 months (M), the median overall survival (OS), time-to-treatment failure (TTF), and progression-free survival (PFS) in all patients was 13.2 M ([95% confidence interval [CI] 7.7-21.8 M), 2.2 M (95%CI, 1.8-2.5 M), and 2.3 M (95%CI, 1.9-2.8 M), respectively. The patients with SWI/SNF complex GA had better OS (median, not reached vs 10.3 M; hazard ratio [HR], 0.40 [95% confidence interval [CI] 0.19–0.86]; p = 0.019) than those without SWI/SNF complex GA. The patients with SWI/SNF complex GA tended to have longer TTF (median, 4.7 M vs 2.1 M; HR, 0.67 [95%CI 0.38–1.17]; p = 0.16) and PFS (median, 5.4 M vs 2.2 M; HR, 0.70 [95%CI 0.39–1.27], p = 0.24) than those without SWI/SNF GA. The objective response rate (ORR) and disease control rate (DCR) in all patients was 13.2% (95%CI, 8.0-20.1) and 40.4% (95%CI, 32.1-49.2), respectively. The ORR and DCR of patients with SWI/SNF complex GA tended to be higher than those without SWI/SNF complex GA (ORR, 30.0% vs 11.9%; p = 0.13: DCR, 70.0% vs 38.1%; p = 0.09), with 1 complete response and 2 partial responses in the patients with SWI/SNF complex GA. Conclusions: The patients with GICs who had SWI/SNF complex GA were more likely to benefit from ICI therapy, suggesting that novel ICI-containing chemotherapies targeting SWI/SNF complex GA are needed for GICs.[Table: see text]
Military-Civilian Partnerships to Expand Emergency Obstetric Care for Both Civilian and Military Mothers-to-Be
Authors: M. Margaret Knudson
Journal: JAMA Network Open (2022)

Tarsicio Uribe-Leitz, MD, MPH; Bridget Matsas, BS; Michael K. Dalton, MD, MPH; Monica A. Lutgendorf, MD; Esther Moberg, MPH; Andrew J. Schoenfeld, MD, MSc; Eric Goralnick, MD, MS; Joel S. Weissman, PhD; Lynette Hamlin, PhD, RN; Zara Cooper, MD, MSc; Tracey P. Koehlmoos, PhD, MHA; Molly P. Jarman, PhD, MPH
PANICKY SANITATION.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Role of inflammation in cardiac valve calcification for patients on long-term continuous ambulatory peritoneal dialysis (CAPD) Angela Y. M. Wang, J Woo, M Wang, P Ho, E Wong, SF Lui, KS Woo, JE Sanderson. Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Hong Kong
Journal: Journal of the American College of Cardiology (2001)
Correction: Endoscopic management of gastrointestinal motility disorders – part 2: European Society of Gastrointestinal Endoscopy (ESGE) Guideline
Authors: Bas L. A. M. Weusten, Maximilien Barret, Albert J. Bredenoord, Pietro Familiari, Jean-Michel Gonzalez, Jeanin E. van Hooft, Vicente Lorenzo-Zúñiga, Hubert Louis, Jan Martinek, Suzanne van Meer, Helmut Neumann, Daniel Pohl, Frederic Prat, Daniel von Renteln, Edoardo Savarino, Rami Sweis, Jan Tack, Radu Tutuian, Sauid Ishaq
Journal: Endoscopy (2020)

Correction to:Endoscopic management of gastrointestinal motility disorders – part 2: European Society of Gastrointestinal Endoscopy (ESGE) GuidelineEndoscopy 2020; 52(07): 600-614DOI: 10.1055/a-1171-3174
Severely decreased cardiac 123 I-metaiodobenzylguanidine uptake predicts future deterioration of heart failure in patients with idiopathic dilated cardiomyopathy Shinichiro Yamada, Kenji Kaihotsu, Akira Takarada, Takatoshi Hayashi, Yasuhiro Tsumura, Akihiro Yoshida, Kohei Yamashiro, Teishi Kajiya. Himeji cardiovascular center, Himeji, Japan
Journal: Journal of the American College of Cardiology (2001)
Gender-based differences in left ventricular structure, remodeling, and function after myocardial infarction Franco Macor, Rita Piazza, Pierluigi Temporelli, Eugenio Cervesato, Pantaleo Giannuzzi, Ioanna Stoian, Aldo P. Maggioni, Gianluigi Nicolosi. Centro Studi ANMCO, Firenze, Italy, Cardiology Dpt A.R.C., Pordenone, Italy
Journal: Journal of the American College of Cardiology (2001)
Antibody detects lymphoma cells in 'normal' blood
Authors: W. A. Check
Journal: JAMA (1979)

A recently developed, highly sensitive method of detecting lymphoma cells in peripheral blood may enable more accurate diagnosis of aplasia following chemotherapy as well as earlier detection of relapse. In two published studies the method has been highly efficient in finding abnormal cells in cases where none had been found by conventional methods. The new technique depends on the facts that (1) 80% of lymphomas, which are solid tumors of the lymph nodes, are composed of B lymphocytes, and (2) these malignant B cells are monoclonal in origin. This means that the immunoglobulin on the surface of the malignant B lymphocytes is all of one type and contains either κ or λ light chains exclusively. Since in the normal state there are approximately equal numbers of lymphocytes expressing κ or λ chains, the presence of malignant cells will skew the distribution of lymphocytes toward an excess of those bearing one
Filling a gap in UK health services: the role of charities
Authors: None The Lancet Haematology
Journal: The Lancet Haematology (2020)

The global economic downturn caused by the COVID-19 pandemic is still evolving, but what is clear is that this impact is already being felt within the charity sector. A report in June by Pro Bono Economics indicated that UK charities could be facing a £10·1 billion funding gap over the next 6 months, with incomes expected to drop by £6·7 billion as demand for their support rises by £3·4 billion. On Aug 17, the UK-based transplant charity Anthony Nolan announced that it was proposing changes to its organisational structure, partly in response to the COVID-19 pandemic and the loss of income that the organisation has experienced.
Kompendium der Kinderheilkunde mit besonderer Berücksichtigung der Säuglingskrankheiten.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The cancer-testis lncRNA lnc-CTHCC promotes hepatocellular carcinogenesis by binding hnRNP K and activating YAP1 transcription
Authors: Anliang Xia, Wenwen Yuan, Qiang Wang, Jianbo Xu, Yayun Gu, Liansheng Zhang, Chen Chen, Zhangding Wang, Di Wu, Qifeng He, Weiwei Yu, Fei Wang, Cailin Xue, Yan Zhang, Guojian Bao, Xuewen Tao, Siyuan Liu, Shouyu Wang, Zhibin Hu, Beicheng Sun
Journal: Nature Cancer (2022)
Prognostic value of amino-terminal pro-atrial natriuretic peptide assessed by sandwich enzyme-linked immunosorbent assay compared to big endothelin in chronic heart failure Rudolf M. Berger, Karin Strecker, Martin Huelsmann, Bernhard Frey, Anja Bojic, Richard Pacher, Brigitte Stanek. University of Vienna, Department of Cardiology, Vienna, Austria
Journal: Journal of the American College of Cardiology (2001)
NHL Progression Risk Cut with Copanlisib–Rituximab Combo
Journal: Cancer Discovery (2021)

According to results from the phase III CHRONOS-3 trial, patients with relapsed indolent non-Hodgkin lymphoma may benefit significantly from the addition of copanlisib, a pan-PI3K inhibitor, to standard rituximab. The combination was safe and nearly halved the risk of disease progression or death, compared with placebo and rituximab.
化脓性汗腺炎患者从生物药物中获益多长时间?
Journal: British Journal of Dermatology (2021)

化脓性汗腺炎是一种慢性皮肤病, 其中表现为持续的、疼痛的、沸腾样病变, 尤其是在腋窝和腹股沟处。通常难以治疗, 重度疾病患者符合接受所谓的生物治疗。唯一注册的生物制剂是阿达木单抗, 这是一种被称为肿瘤坏死因子 a (TNF‐α) 的炎性介质单克隆抗体, 尽管也使用了其他生物制剂, 如英夫利昔单抗 (另一种 TNF‐a 拮抗剂) 。遗憾的是, 这些药物有时可能会随着时间的推移而失效, 因为患者会产生抗药物抗体, 或可能出现副作用。对化脓性汗腺炎患者使用这些治疗的长期结果仍知之甚少。
Peripartum Cardiomyopathy
Authors: Zolt Arany, Uri Elkayam
Journal: Circulation (2016)

Peripartum cardiomyopathy is a potentially life-threatening pregnancy-associated disease that typically arises in the peripartum period and is marked by left ventricular dysfunction and heart failure. The disease is relatively uncommon, but its incidence is rising. Women often recover cardiac function, but long-lasting morbidity and mortality are not infrequent. Management of peripartum cardiomyopathy is largely limited to the same neurohormonal antagonists used in other forms of cardiomyopathy, and no proven disease-specific therapies exist yet. Research in the past decade has suggested that peripartum cardiomyopathy is caused by vascular dysfunction, triggered by late-gestational maternal hormones. Most recently, information has also indicated that many cases of peripartum cardiomyopathy have genetic underpinnings. We review here the known epidemiology, clinical presentation, and management of peripartum cardiomyopathy, as well as the current knowledge of the pathophysiology of the disease.
Abstract P240: Clinical Outcomes in Patients With Takotsubo’s Cardiomyopathy Who Have Undergone Cardiac Catherterization at Presentation vs. Those Who Have Not: A Two Community Based Hospitals Experience
Authors: Umama Gorsi, Muhammad Shafi, Mary Roberts, Chester Hedgepeth
Journal: Circulation (2017)

Background: Diagnosis of Takotsubo’s Cardiomyopathy (TC) remains a challenge due to similar presentation to acute coronary syndrome. Coronary catheterization (CC) proven clean coronaries is important to diagnose TC. However, it is not uncommon that CC is occasionally delayed due to unstable medical condition and/or high risk for CC. We hypothesized that patients with TC had similar outcomes whether they underwent CC at presentation or were diagnosed using non-invasive imaging techniques. Methods: Retrospective chart review of data from Memorial Hospital of Rhode Island and Kent Hospital, two community based hospitals, from June 2008 to March 2016 was done. Thirty nine adult patients &gt; 18 years of age admitted to the intensive care unit or medical floor with chest pain, shortness of breath, elevated troponin, EKG changes, and new non-regional wall motion abnormalities or reduce ejection fraction, with suspected TC were enrolled. Patients were divided into 2 groups based on diagnostic approach of TC: Baseline echo findings suggestive of TC with EF improvement at follow up (non-CC) vs. clean coronaries by CC. Outcomes of the two groups were compared using Chi-square analysis, analysis of variance (ANOVA) and Mann-Whitney Test appropriately. Results: Out of 39 patients, 20 underwent CC while 19 did not. Mean age was not different between the 2 groups (69.1±11.8 vs. 62.4±14.0, p= NS) but CC group had more females (95 %, 19 of 20 vs 68.4%, 13 of 19; p=0.031). Most common chief complaint at the time of admission in both groups was shortness of breath (60.0%, 12 of 20 vs 68.4%, 13 of 19; p=0.548). Admission heart rate was significantly higher in non-CC vs. CC patients (102.3± 19.3 vs 85.4±85.4; p=0.007). Third troponin was higher in non-CC group (1.926 ± 2.667 vs 0.775± 1.378, p=0.017). All other admission and in-hospital findings and drug management in both groups were similar. Both CC and non-CC groups had comparable outcomes: intubation (15%, 3 of 20 vs 21.1%, 4 of 19) , heart failure (21.2 %, 4 of 20 vs 15.8%, 3 of 19), shock (0 %, 0 of 20 vs 5.3% 1 of 19 ), stroke (5 %, 1 of 20 vs 0%, 0 of 19), death (5.3 % 1 of 20 vs 5.3% 1 of 19 ), recovery (65%,13 of 20 vs 52.9 % 10 of 19) p=NS for all. ICU admission (42.1%, 8 of 20 vs 52.6%, 10 of 19; p=NS) and length of stay (8.21±7.82 days vs 5.75±5.67 days; p=NS) was not significantly different between the 2 groups. Both groups showed analogous improvement in ejection fraction (21.92 ± 13.96 vs 20.63 ± 13.21; p= 0.835) on a follow up Echo done within 2 weeks to 6 months. Conclusion: This study shows no difference in outcomes between TC patients diagnosed with CC or TTE on admission. However, CC should still be done on admission for diagnosis of TC until large non-invasive diagnostic imaging modalities (such as myocardial perfusion echocardiogram) trials show high specificity for diagnosis of TC.
Union Internationale Contre le Cancer (UICC)
Journal: JNCI Journal of the National Cancer Institute (1964)

Union Internationale Contre le Cancer (UICC) JNCI: Journal of the National Cancer Institute, Volume 33, Issue 6, December 1964, Pages 1081–1082, https://doi.org/10.1093/jnci/33.6.1081 Published: 01 December 1964
Mortality and clinical cure rates for pneumonia: a systematic review, meta-analysis, and trial sequential analysis of randomized control trials comparing bactericidal and bacteriostatic antibiotic treatments
Authors: Naveed Saleem, Francis Ryckaert, Timothy Arthur Chandos Snow, Giovanni Satta, Mervyn Singer, Nishkantha Arulkumaran
Journal: Clinical Microbiology and Infection (2022)
Correction
Journal: BMJ (1921)

IODINE TREATMENT.W. T.," who desires to resort to the intensive iodine treatment for tuberculosis and arthritis, finids that thie tincture of the Frenich Codex wbich is recommended for this purpose con- tains no potassium iodide.The proportion of iodine is 1 grain in 10 minims; when this amount is added to a small quautity of water a precipitate occurs.*.*We learn that at University College Hospital,'where the colicentrated 10 per cent.tincture of the French Codex is used, it is customary to dispense it undiluted and to direct the patient to mieasure the drops into water or milk and drink off the mixture at once.The preparation " Iodinosol " (E.T. Pearson and Co., London Road, Mitcham, Surrey), contains 6 per cent.iodine (approximately) and can be diluted with liquid paraffin, or dispensed in full strength to be taken in milk or on sugar.It is more difficult to measure than an alcoholic solution.INCOME TAX."G.P." inquires whether the forthcoming reduction in the -capitation fees for panel patients is a "specific cause" eutitling him to a reduction from the average basis of assessment.
Superiority
Authors: Jeremy Hugh Baron
Journal: BMJ (2004)

There is increasing evidence that treatment with atypical antipsychotics may be associated with metabolic disturbances such as impaired glucose metabolism and hyperlipidaemia. 20The trials we reviewed did not find evidence of such metabolic disturbances, but it is unlikely that these events would become apparent over only 6-12 weeks. ConclusionsAlthough atypical antipsychotic drugs are being used with increasing frequency, only a few randomised trials have evaluated their use in BPSD.Additional evidence is required to support the perception of an improved efficacy and adverse event profile relative to typical antipsychotic agents.In light of concern regarding the potential adverse events associated with treatment with these drugs, further evidence is required before their use can be endorsed in the management of BPSD.