tbuckley/cabot-search huggingface dataset:
Multifunctional nanoplatforms co-delivering combinatorial dual-drug for eliminating cancer multidrug resistance
Authors: Xiao Wei, Mingzhu Song, Weijie Li, Jing Huang, Guang Yang, Yi Wang
Journal: Theranostics (2021)

Clinically, the primary cause of chemotherapy failure belongs to the occurrence of cancer multidrug resistance (MDR), which directly leads to the recurrence and metastasis of cancer along with high mortality. More and more attention has been paid to multifunctional nanoplatform-based dual-therapeutic combination to eliminate resistant cancers. In addition to helping both cargoes improve hydrophobicity and pharmacokinetic properties, increase bioavailability, release on demand and enhance therapeutic efficacy with low toxic effects, these smart co-delivery nanocarriers can even overcome drug resistance. Here, this review will not only present different types of co-delivery nanocarriers, but also summarize targeted and stimuli-responsive combination nanomedicines. Furthermore, we will focus on the recent progress in the co-delivery of dual-drug using such intelligent nanocarriers for surmounting cancer MDR. Whereas it remains to be seriously considered that there are some knotty issues in the fight against MDR of cancers via using co-delivery nanoplatforms, including limited intratumoral retention, the possible changes of combinatorial ratio under complex biological environments, drug release sequence from the nanocarriers, and subsequent free-drug resistance after detachment from the nanocarriers. It is hoped that, with the advantage of continuously developing nanomaterials, two personalized therapeutic agents in combination can be better exploited to achieve the goal of cooperatively combating cancer MDR, thus advancing the time to clinical transformation.
Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms
Authors: Eric Song, Christopher M. Bartley, Ryan D. Chow, Thomas T. Ngo, Ruoyi Jiang, Colin R. Zamecnik, Ravi Dandekar, Rita P. Loudermilk, Yile Dai, Feimei Liu, Sara Sunshine, Jamin Liu, Wesley Wu, Isobel A. Hawes, Bonny D. Alvarenga, Trung Huynh, Lindsay McAlpine, Nur-Taz Rahman, Bertie Geng, Jennifer Chiarella, Benjamin Goldman-Israelow, Chantal B.F. Vogels, Nathan D. Grubaugh, Arnau Casanovas-Massana, Brett S. Phinney, Michelle Salemi, Jessa R. Alexander, Juan A. Gallego, Todd Lencz, Hannah Walsh, Anne E. Wapniarski, Subhasis Mohanty, Carolina Lucas, Jon Klein, Tianyang Mao, Jieun Oh, Aaron Ring, Serena Spudich, Albert I. Ko, Steven H. Kleinstein, John Pak, Joseph L. DeRisi, Akiko Iwasaki, Samuel J. Pleasure, Michael R. Wilson, Shelli F. Farhadian
Journal: Cell Reports Medicine (2021)

Individuals with coronavirus disease 2019 (COVID-19) frequently develop neurological symptoms, but the biological underpinnings of these phenomena are unknown. Through single-cell RNA sequencing (scRNA-seq) and cytokine analyses of cerebrospinal fluid (CSF) and blood from individuals with COVID-19 with neurological symptoms, we find compartmentalized, CNS-specific T cell activation and B cell responses. All affected individuals had CSF anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies whose target epitopes diverged from serum antibodies. In an animal model, we find that intrathecal SARS-CoV-2 antibodies are present only during brain infection and not elicited by pulmonary infection. We produced CSF-derived monoclonal antibodies from an individual with COVID-19 and found that these monoclonal antibodies (mAbs) target antiviral and antineural antigens, including one mAb that reacted to spike protein and neural tissue. CSF immunoglobulin G (IgG) from 5 of 7 patients showed antineural reactivity. This immune survey reveals evidence of a compartmentalized immune response in the CNS of individuals with COVID-19 and suggests a role of autoimmunity in neurologic sequelae of COVID-19.
Evolution of delayed resistance to immunotherapy in a melanoma responder
Authors: David Liu, Jia-Ren Lin, Emily J. Robitschek, Gyulnara G. Kasumova, Alex Heyde, Alvin Shi, Adam Kraya, Gao Zhang, Tabea Moll, Dennie T. Frederick, Yu-An Chen, Shu Wang, Denis Schapiro, Li-Lun Ho, Kevin Bi, Avinash Sahu, Shaolin Mei, Benchun Miao, Tatyana Sharova, Christopher Alvarez-Breckenridge, Jackson H. Stocking, Tommy Kim, Riley Fadden, Donald Lawrence, Mai P. Hoang, Daniel P. Cahill, Mohsen Malehmir, Martin A. Nowak, Priscilla K. Brastianos, Christine G. Lian, Eytan Ruppin, Benjamin Izar, Meenhard Herlyn, Eliezer M. Van Allen, Katherine Nathanson, Keith T. Flaherty, Ryan J. Sullivan, Manolis Kellis, Peter K. Sorger, Genevieve M. Boland
Journal: Nature Medicine (2021)
PERFORMANCE OF A NOVEL MULTI-BIOMARKER BASED SCORING MODEL FOR THE PREDICTION OF INCIDENT CARDIOVASCULAR EVENTS: A POOLED MULTI-NATIONAL VALIDATION STUDY
Authors: Emmanuel Ekanem, Cian McCarthy, Johannes Neumann, Palak Shah, Craig Magaret, Grady Barnes, Rhonda Rhyne, Dirk Westermann, Christopher DeFilippi, James Januzzi
Journal: Journal of the American College of Cardiology (2021)
Mass screening for asymptomatic SARS-CoV-2 infection
Authors: Angela E Raffle, Mike Gill
Journal: BMJ (2021)

Grape glycosides are, in part, important aroma and flavor precursors. Their quantification may offer a means of determining the impact of viticultural practices, such as leaf removal, on potential wine quality. Fruit zone leaf removal of Riesling and Chardonnay grapevines grown at two sites for two seasons was evaluated for its influence on total and phenol-free grape glycosides at harvest. Vines were trained to a low bilateral cordon system at one vineyard and a high bilateral cordon at the other. The concentrations of total and phenol-free glycosides were higher in Riesling and Chardonnay fruit from leaf-pulled <i>vs</i> control vines at three of four harvest dates. Phenol-free glycosides averaged 80% of the total in Riesling juice and 66% of the total in Chardonnay. Grapevine canopy microclimate plays an important role in determining fruit composition, although knowledge about the relationship between microclimate and aroma/flavor development is limited. This study illustrates the affect of microclimate manipulation on grape glycosides, important components of fruit quality.
Neutrophil oxidative stress mediates obesity-associated vascular dysfunction and metastatic transmigration
Authors: Sheri A. C. McDowell, Robin B. E. Luo, Azadeh Arabzadeh, Samuel Doré, Nicolas C. Bennett, Valérie Breton, Elham Karimi, Morteza Rezanejad, Ryan R. Yang, Katherine D. Lach, Marianne S. M. Issac, Bozena Samborska, Lucas J. M. Perus, Dan Moldoveanu, Yuhong Wei, Benoit Fiset, Roni F. Rayes, Ian R. Watson, Lawrence Kazak, Marie-Christine Guiot, Pierre O. Fiset, Jonathan D. Spicer, Andrew J. Dannenberg, Logan A. Walsh, Daniela F. Quail
Journal: Nature Cancer (2021)
Assessing Child Abuse Hotline Inquiries in the Wake of COVID-19
Authors: Robin Ortiz, Rachel Kishton, Laura Sinko, Michelle Fingerman, Diane Moreland, Joanne Wood, Atheendar Venkataramani
Journal: JAMA Pediatrics (2021)

Assessing Child Abuse Hotline Inquiries in the Wake of COVID-19: Answering the CallExperts are concerned about increasing child distress and maltreatment alongside decreasing exposure to mandated child abuse reporters, such as teachers, during the COVID-19 pandemic. 1Hotlines may serve as alternate means to identify family violence and support at-risk children.This study assessed the volume of calls and texts to a national child abuse hotline during the pandemic compared with the prior year.Methods | This cross-sectional study was conducted using restricted-access data from Childhelp, the only national hotline with a primary focus on child abuse and neglect.Childhelp has offered 24-hour multilingual counseling across all US states via phone call inquiries from youth and concerned adults since 1982 and via text message since 2019. 2,3Users anonymously provide optional demographic information, including their relationship to the youth (eg, themselves, parent, neighbor, or teacher).Users are then connected to a crisis counselor.Study data included the number of inquiries, modality (call or text), and demographic characteristics (inquirer's age category, sex, and identifier type).The University of Pennsylvania Institutional Review Board deemed this study nonhuman subjects research.Given the initiation of school closures on March 5, 2020, we examined differences in demographic information by modality between March 1, 2019, and May 27, 2019, and March 1, 2020, and May 26, 2020, using χ 2 and Fischer exact tests.We then assessed inquiries for each full year beginning
Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients
Authors: Carole Le Coz, David N. Nguyen, Chun Su, Brian E. Nolan, Amanda V. Albrecht, Suela Xhani, Di Sun, Benjamin Demaree, Piyush Pillarisetti, Caroline Khanna, Francis Wright, Peixin Amy Chen, Samuel Yoon, Amy L. Stiegler, Kelly Maurer, James P. Garifallou, Amy Rymaszewski, Steven H. Kroft, Timothy S. Olson, Alix E. Seif, Gerald Wertheim, Struan F.A. Grant, Linda T. Vo, Jennifer M. Puck, Kathleen E. Sullivan, John M. Routes, Viktoria Zakharova, Anna Shcherbina, Anna Mukhina, Natasha L. Rudy, Anna C.E. Hurst, T. Prescott Atkinson, Titus J. Boggon, Hakon Hakonarson, Adam R. Abate, Joud Hajjar, Sarah K. Nicholas, James R. Lupski, James Verbsky, Ivan K. Chinn, Michael V. Gonzalez, Andrew D. Wells, Alex Marson, Gregory M.K. Poon, Neil Romberg
Journal: The Journal of Experimental Medicine (2021)

The pioneer transcription factor (TF) PU.1 controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing nonpioneer TFs to enter otherwise inaccessible genomic sites. PU.1 deficiency fatally arrests lymphopoiesis and myelopoiesis in mice, but human congenital PU.1 disorders have not previously been described. We studied six unrelated agammaglobulinemic patients, each harboring a heterozygous mutation (four de novo, two unphased) of SPI1, the gene encoding PU.1. Affected patients lacked circulating B cells and possessed few conventional dendritic cells. Introducing disease-similar SPI1 mutations into human hematopoietic stem and progenitor cells impaired early in vitro B cell and myeloid cell differentiation. Patient SPI1 mutations encoded destabilized PU.1 proteins unable to nuclear localize or bind target DNA. In PU.1-haploinsufficient pro-B cell lines, euchromatin was less accessible to nonpioneer TFs critical for B cell development, and gene expression patterns associated with the pro- to pre-B cell transition were undermined. Our findings molecularly describe a novel form of agammaglobulinemia and underscore PU.1's critical, dose-dependent role as a hematopoietic euchromatin gatekeeper.
CLINICAL CHARACTERISTICS AND OUTCOMES IN ASIAN PATIENTS WITH HEART FAILURE AND MID-RANGE EJECTION FRACTION
Authors: Julian Tay Cheong Kiat, Shaw Yang Chia, Siew Hui Michelle Koh, David Sim, Ping Chai, Seet Yoong Loh, Fazlur Rehman Jaufeerally, Sheldon Lee Shao Guang, Zhan Yun Patrick Lim, Jonathan Yap
Journal: Journal of the American College of Cardiology (2021)
PERSISTANT ANGINA IN WOMEN WITH ISCHEMIA AND NO OBSTRUCTIVE CORONARY ARTERIES—RESULTS FROM THE WOMEN'S ISCHEMIA SYNDROME EVALUATION-CORONARY VASCULAR DYSFUNCTION (WISE-CVD) CONTINUATION PROJECT
Authors: Judy Luu, Janet Wei, Chrisandra Shufelt, Anum Asif, Benita Tjoe, Galen Cook-Wiens, Eileen Handberg, Puja Mehta, Jenna Maughan, Daniel Berman, Louise Thomson, Carl Pepine, C. Noel Bairey Merz
Journal: Journal of the American College of Cardiology (2021)
DIGEORGE SYNDROME IS A SIGNIFICANT RISK FACTOR FOR THE DEVELOPMENT OF INFECTIOUS ENDOCARDITIS FOLLOWING TRANSCATHETER PULMONARY VALVE REPLACEMENT WITH THE MELODY VALVE
Authors: Graham Stockdale, Joseph Graziano, Wayne Franklin, Jordan Awerbach, Byron Garn, John Breinholt, Theresa Grebe, Jonathan D. Plasencia, Hallie Meador, Colby Nielsen, Stephen Pophal
Journal: Journal of the American College of Cardiology (2021)
RISK ASSESSMENT IN CARDIAC SURGICAL PROCEDURES USING THE SP-SCORE (SAO PAULO RISK SCORE) - AN INDEPENDENT VALIDATION
Authors: Marcelo Arruda Nakazone, Maurício N. Machado, Laura O. Machado, Júlia O. Machado, Omar A.V. Mejía, Luiz A.F. Lisboa, Lilia N. Maia
Journal: Journal of the American College of Cardiology (2021)
Nanomedicine for acute respiratory distress syndrome: The latest application, targeting strategy, and rational design
Authors: Qi Qiao, Xiong Liu, Ting Yang, Kexin Cui, Li Kong, Conglian Yang, Zhiping Zhang
Journal: Acta Pharmaceutica Sinica B (2021)

Acute respiratory distress syndrome (ARDS) is characterized by the severe inflammation and destruction of the lung air-blood barrier, leading to irreversible and substantial respiratory function damage. Patients with coronavirus disease 2019 (COVID-19) have been encountered with a high risk of ARDS, underscoring the urgency for exploiting effective therapy. However, proper medications for ARDS are still lacking due to poor pharmacokinetics, non-specific side effects, inability to surmount pulmonary barrier, and inadequate management of heterogeneity. The increased lung permeability in the pathological environment of ARDS may contribute to nanoparticle-mediated passive targeting delivery. Nanomedicine has demonstrated unique advantages in solving the dilemma of ARDS drug therapy, which can address the shortcomings and limitations of traditional anti-inflammatory or antioxidant drug treatment. Through passive, active, or physicochemical targeting, nanocarriers can interact with lung epithelium/endothelium and inflammatory cells to reverse abnormal changes and restore homeostasis of the pulmonary environment, thereby showing good therapeutic activity and reduced toxicity. This article reviews the latest applications of nanomedicine in pre-clinical ARDS therapy, highlights the strategies for targeted treatment of lung inflammation, presents the innovative drug delivery systems, and provides inspiration for strengthening the therapeutic effect of nanomedicine-based treatment.
THIRTY-DAY READMISSION RISK IN HEART FAILURE PATIENTS WHO RECEIVED A PALLIATIVE CARE CONSULT DURING HOSPITALIZATION COMPARED WITH THOSE WHO DID NOT RECEIVE A PALLIATIVE CARE CONSULT - AN INSIGHT FROM A NATIONWIDE DATABASE
Authors: Radhika Deshpande, Yasser Al-Khadra, Prashanth Singanallur, Basma Al-bast, Venkata Missula, Raad Al Tamimi, Manasik Abdu, Nour Albast, Abhishek Kulkarni, Kalyan Potu
Journal: Journal of the American College of Cardiology (2021)
CARDIOVASCULAR RISK PROFILES IN MARIJUANA SMOKERS
Authors: Precious Akanyirige, Ashley Ezema, Ellen Boakye, Alana Bryant, Kamari Jackson, Edwin Mandieka, Ramael Ohiomoba, Oluseyi Princewill, Quentin Youmans, Michael Blaha, Roger Blumenthal, Alana Lewis, Ike Okwuosa
Journal: Journal of the American College of Cardiology (2021)
QUANTITATIVE CARDIOVASCULAR MAGNETIC RESONANCE AND TECHNETIUM PYROPHOSPHATE IN PATIENTS WITH SUSPECTED CARDIAC AMYLOIDOSIS
Authors: Golnaz Roshankar, Geneva White, Sebastien Cadet, Nowell Fine, Denise Chan, James White, Victor Jimenez-Zepeda, Piotr Slomka, Robert Miller
Journal: Journal of the American College of Cardiology (2021)
Abstract 2501: Anaemia is associated with poor outcome in patients with heart failure and preserved ejection fraction (HF PEF). Findings from the Irbesartan in Heart Failure with Preserved Systolic Function Trial (I-PRESERVE).
Authors: Michel Komajda, Robert S McKelvie, John J McMurray, Michael R Zile, Mark Donovan, Agatha Ptaszynska, Barry M Massie, Peter Carson
Journal: Circulation (2007)

Background: Anaemia is frequent in patients with HF and reduced left ventricular ejection fraction and is an independent predictor of mortality and rehospitalisation. The prevalence of anaemia and ...
Self-curling electroconductive nerve dressing for enhancing peripheral nerve regeneration in diabetic rats
Authors: Can Liu, Lei Fan, Zhenming Tian, Huiquan Wen, Lei Zhou, Pengfei Guan, Yian Luo, Chuncheung Chan, Guoxin Tan, Chengyun Ning, Limin Rong, Bin Liu
Journal: Bioactive Materials (2021)

Conductive scaﬀolds have been shown to exert a therapeutic effect on patients suffering from peripheral nerve injuries (PNIs). However, conventional conductive conduits are made of rigid structures and have limited applications for impaired diabetic patients due to their mechanical mismatch with neural tissues and poor plasticity. We propose the development of biocompatible electroconductive hydrogels (ECHs) that are identical to a surgical dressing in this study. Based on excellent adhesive and self-healing properties, the thin film-like dressing can be easily attached to the injured nerve fibers, automatically warps a tubular structure without requiring any invasive techniques. The ECH offers an intimate and stable electrical bridge coupling with the electrogenic nerve tissues. The in vitro experiments indicated that the ECH promoted the migration and adhesion of the Schwann cells. Furthermore, the ECH facilitated axonal regeneration and remyelination in vitro and in vivo through the MEK/ERK pathway, thus preventing muscle denervation atrophy while retaining functional recovery. The results of this study are likely to facilitate the development of non-invasive treatment techniques for PNIs in diabetic patients utilizing electroconductive hydrogels.
OUTCOMES OF PATIENTS ADMITTED FOR ACUTE AORTIC DISSECTION BASED ON LOCATION OF THE HOSPITAL, RURAL VS. URBAN: ANALYSIS OF NATIONAL INPATIENT SAMPLE
Authors: Muhammad Usman Almani, Muhammad Usman, Cyra-Yoonsun Kang, Emmanuel Akuna, Iriagbonse Rotimi Asemota, Mahmoud Elbermawy, Raquel Soon-Shiong, Dimeji Williams, Smriti Khanal, Bharosa Sharma, Muhammad Talha Ayub, John H. Stroger
Journal: Journal of the American College of Cardiology (2021)
FINAL TWO-YEAR RESULTS FROM THE RANDOMIZED ONYX ONE TRIAL IN HIGH BLEEDING RISK PATIENTS TREATED WITH 1-MONTH DAPT
Authors: Stephan Windecker, Elvin Kedhi, Azeem Latib, David Kandzari, Ajay Kirtane, Roxana Mehran, Matthew Price, Alexandre Abizaid, Daniel Simon, Stephen Worthley, Azfar Zaman, Gwenn Wetzels, Te-Hsin Lung, Steven Marx, Ziad Ali, Gregg Stone
Journal: Journal of the American College of Cardiology (2021)
Extracellular Signal‐Regulated Kinase 5 Regulates the Malignant Phenotype of Cholangiocarcinoma Cells
Authors: Alessandra Gentilini, Giulia Lori, Alessandra Caligiuri, Chiara Raggi, Giovanni Di Maira, Mirella Pastore, Benedetta Piombanti, Tiziano Lottini, Annarosa Arcangeli, Stefania Madiai, Nadia Navari, Jesus M. Banales, Sabina Di Matteo, Domenico Alvaro, Lea Duwe, Jesper B. Andersen, Alessandro Tubita, Ignazia Tusa, Luca Di Tommaso, Claudia Campani, Elisabetta Rovida, Fabio Marra
Journal: Hepatology (2021)

Background and Aims Cholangiocarcinoma (CCA) is characterized by high resistance to chemotherapy and poor prognosis. Several oncogenic pathways converge on activation of extracellular signal‐regulated kinase 5 (ERK5), whose role in CCA has not been explored. The aim of this study was to investigate the role of ERK5 in the biology of CCA. Approach and Results ERK5 expression was detected in two established (HuCCT‐1 and CCLP‐1) and two primary human intrahepatic CCA cell lines (iCCA58 and iCCA60). ERK5 phosphorylation was increased in CCA cells exposed to soluble mediators. In both HuCCT‐1 and CCLP‐1 cells, ERK5 was localized in the nucleus, and exposure to fetal bovine serum (FBS) further increased the amount of nuclear ERK5. In human CCA specimens, ERK5 mRNA expression was increased in tumor cells and positively correlated with portal invasion. ERK5 protein levels were significantly associated with tumor grade. Growth, migration, and invasion of CCA cells were decreased when ERK5 was silenced using specific short hairpin RNA (shRNA). The inhibitory effects on CCA cell proliferation, migration and invasion were recapitulated by treatment with small molecule inhibitors targeting ERK5. In addition, expression of the angiogenic factors VEGF and angiopoietin 1 was reduced after ERK5 silencing. Conditioned medium from ERK5‐silenced cells had a lower ability to induce tube formation by human umbilical vein endothelial cells and to induce migration of myofibroblasts and monocytes/macrophages. In mice, subcutaneous injection of CCLP‐1 cells silenced for ERK5 resulted in less frequent tumor development and smaller size of xenografts compared with cells transfected with nontargeting shRNA. Conclusions ERK5 is a key mediator of growth and migration of CCA cells and supports a protumorigenic crosstalk between the tumor and the microenvironment.
SEX DIFFERENCES IN CATHETER ABLATION OUTCOME AND HEART FAILURE IN ATRIAL FIBRILLATION PATIENTS: INSIGHTS FROM THE KANSAI PLUS ATRIAL FIBRILLATION REGISTRY
Authors: Nobuaki Tanaka, Koichi Inoue, Atsushi Kobori, Kazuaki Kaitani, Takeshi Morimoto, Toshiya Kurotobi, Itsuro Morishima, Yumie Matsui, Hirosuke Yamaji, Yuko Nakazawa, Kengo Kusano, Masato Okada, Koji Tanaka, Yuko Hirao, Yasushi Koyama, Atsunori Okamura, Katsuomi Iwakura, Kenshi Fujii, Takeshi Kimura, Satoshi Shizuta
Journal: Journal of the American College of Cardiology (2021)
Intron 4–5 hTERT DNA Hypermethylation in Merkel Cell Carcinoma: Frequency, Association with Other Clinico-pathological Features and Prognostic Relevance
Authors: Costantino Ricci, Luca Morandi, Francesca Ambrosi, Alberto Righi, Dino Gibertoni, Francesca Maletta, Claudio Agostinelli, Angelo Gianluca Corradini, Silvia Uccella, Silvia Asioli, Fausto Sessa, Stefano La Rosa, Mauro Giulio Papotti, Sofia Asioli
Journal: Endocrine Pathology (2021)

Abstract Merkel cell carcinoma (MCC) is an aggressive skin tumor with neuroendocrine differentiation, mainly affecting elderly population or immunocompromised individuals. As methylation of the human telomerase reverse transcriptase (m hTERT ) has been shown to be a prognostic factor in different tumors, we investigated its role in MCC, in particular in intron 4–5 where rs10069690 has been mapped and recognized as a cancer susceptibility locus. DNA methylation analysis of hTERT gene was assessed retrospectively in a cohort of 69 MCC patients from the University of Bologna, University of Turin and University of Insubria. Overall mortality was evaluated with Kaplan-Meier curves and multivariable Royston-Parmar models. High levels of m hTERT (m hTERT high ) (HR = 2.500, p = 0.015 ) and p63 (HR = 2.659, p = 0.016 ) were the only two clinico-pathological features significantly associated with a higher overall mortality at the multivariate analysis. We did not find different levels of m hTERT between MCPyV (+) and (−) cases (21 vs 14, p = 0.554 ); furthermore, m hTERT high was strongly associated with older age (80.5 vs 72 years, p = 0.026 ), no angioinvasion (40.7% vs 71.0%, p = 0.015 ), lower Ki67 (50 vs 70%, p = 0.005 ), and PD-L1 expressions in both tumor (0 vs 3%, p = 0.021 ) and immune cells (0 vs 10%, p = 0.002 ). m hTERT is a frequently involved epigenetic mechanism and a relevant prognostic factor in MCC. In addition, it belongs to the shared oncogenic pathways of MCC (MCPyV and UV-radiations) and it could be crucial, together with other epigenetic and genetic mechanisms as gene amplification, in determining the final levels of hTERT mRNA and telomerase activity in these patients.
ALK Inhibitors in Neuroblastoma: A Sprint from Bench to Bedside
Authors: Johannes H. Schulte, Angelika Eggert
Journal: Clinical Cancer Research (2021)

Abstract Activating mutations of the anaplastic lymphoma kinase (ALK) gene were identified in the pediatric tumor neuroblastoma, in 2008. Rapid translation of this finding into targeted neuroblastoma therapy was facilitated by the availability of ALK inhibitors developed for adult malignancies and an efficient preclinical and clinical research program. See related article by Foster et al., p. 3543
Integration of Equipoise into Eligibility Criteria in the STARRT-AKI Trial
Authors: Ron Wald, Sean M. Bagshaw, Sean M. Bagshaw, Ron Wald, Neill K. J. Adhikari, Rinaldo Bellomo, Didier Dreyfuss, Bin Du, Martin P. Gallagher, Stéphane Gaudry, Eric A. Hoste, François Lamontagne, Michael Joannidis, Kathleen D. Liu, Daniel F. McAuley, Shay P. McGuinness, Alistair D. Nichol, Marlies Ostermann, Paul M. Palevsky, Haibo Qiu, Ville Pettilä, Antoine G. Schneider, Orla M. Smith, Suvi Vaara, Matthew Weir
Journal: American Journal of Respiratory and Critical Care Medicine (2021)