High-Dose Vitamin C and Iron Overload
Authors: Bill Sardi
Journal: Annals of Internal Medicine (2004)

Letters18 May 2004High-Dose Vitamin C and Iron OverloadBill SardiBill SardiFrom Knowledge of Health, Inc., San Dimas, CA 91773.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-10-200405180-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The report by Mallory and colleagues (1) may have mistakenly attributed a case of iron overload and accompanying fatigue to high-dose vitamin C supplementation (15 000 mg/d) in a 59-year-old woman who also took an iron supplement. The report stated that “overall iron stores were not increased in the setting of supplementation with moderate doses of vitamin C.” However, the reference cited to substantiate this claim was a study conducted among women 20 to 45 years of age who were still controlling iron through monthly menstruation (2). Median age for the onset of menopause is about 52 years ...References1. Mallory MA, Sthapanachai C, Kowdley KV. Iron overload related to excessive vitamin C intake [Letter]. Ann Intern Med. 2003;139:532-3. [PMID: 13679342] LinkGoogle Scholar2. Hunt JR, Gallagher SK, Johnson LK. Effect of ascorbic acid on apparent iron absorption by women with low iron stores. Am J Clin Nutr. 1994;59:1381-5. [PMID: 8198064] CrossrefMedlineGoogle Scholar3. Kato I, Toniolo P, Akhmedkhanov A, Koenig KL, Shore R, Zeleniuch-Jacquotte A. Prospective study of factors influencing the onset of natural menopause. J Clin Epidemiol. 1998;51:1271-6. [PMID: 10086819] CrossrefMedlineGoogle Scholar4. Custer EM, Finch CA, Sobel RE, Zettner A. Population norms for serum ferritin. J Lab Clin Med. 1995;126:88-94. [PMID: 7602240] MedlineGoogle Scholar5. Nishioka E, Funasaka Y, Bito T, Ito A, Tani M, Kawara A, et al . Porphyria cutanea tarda with menopausal exacerbation: the possible role of menstruation as natural phlebotomy. J Am Acad Dermatol. 2003;49:547-50. [PMID: 12963930] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Knowledge of Health, Inc., San Dimas, CA 91773. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoIron Overload Related to Excessive Vitamin C Intake Mark A. Mallory , Chalengpoj Sthapanachai , and Kris V. Kowdley High-Dose Vitamin C and Iron Overload Kris V. Kowdley Metrics Cited byHuman Semen Samples with High Antioxidant Reservoir May Exhibit Lower Post-Cryopreservation Recovery of Sperm MotilityClinical evaluation of endoscopic hemostasis in patients with ulcerative gastroduodenal bleedingAssociation Between Plasma Vitamin C Concentrations and Blood Pressure in the European Prospective Investigation Into Cancer-Norfolk Population-Based StudyEffect of oral esomeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers 18 May 2004Volume 140, Issue 10Page: 846KeywordsFatigueFerritinMenopauseVitamin C ePublished: 18 May 2004 Issue Published: 18 May 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...