tbuckley/cabot-search huggingface dataset:
Blue Book of Pharmacologic Therapeutics.
Authors: G. E. Johnson
Journal: Annals of Internal Medicine (1985)

Emphasizing the practical aspects of drug therapy, this manual provides a quick, succinct, and comprehensive review of drug therapy. Covers the fundamentals of the disease process, the principles of drug therapy, and the mechanisms of action and pharmacologic effects of each drug system. Excellent 4-column tables list the generic and trade name of each drug, and its therapeutic uses, including dosage, adverse effects, contraindications, precautions, and interactions.
The Value of Estimated Functional Capacity in Estimating Outcome
Authors: Leslee J. Shaw, Marian B. Olson, Kevin Kip, Sheryl F. Kelsey, B. Delia Johnson, Daniel B. Mark, Steven E. Reis, Sunil Mankad, William J. Rogers, Gerald M. Pohost, Christopher B. Arant, Timothy R. Wessel, Bernard R. Chaitman, George Sopko, Eileen Handberg, Carl J. Pepine, C. Noel Bairey Merz
Journal: Journal of the American College of Cardiology (2006)
Abstract 1220: Thioredoxin 1 Negatively Regulates Angiotensin II-Induced Cardiac Hypertrophy through Upregulation of miR-98
Authors: Yanfei Yang, Tetsuro Ago, Danish Sayed, Maha Abdellatif, Junichi Sadoshima
Journal: Circulation (2007)

Thioredoxin 1 (Trx1) is a 12 kD antioxidant, which protects the heart through multiple mechanisms, including suppression of hypertrophy. We examined the effect of Trx1 on angiotensin II (AII)-induced cardiac hypertrophy (CH). Continuous infusion of a subpressor dose (200 ng/kg/min) of AII by osmotic pump for 2 weeks induced CH (+10% in left ventricular weight/body weight, p&lt;0.05) in mice. AII-induced CH was significantly attenuated in cardiac specific Trx1 transgenic mice (Tg-Trx1) (+1%, ns), whereas it was significantly enhanced in dominant negative Trx1 mice (Tg-DN-Trx1) (+26%, p&lt;0.05). These results suggest that Trx1 is a negative regulator of AII-induced CH. MicroRNAs are naturally existing small noncoding RNA molecules that downregulate posttranscriptional gene expression. In order to examine the involvement of microRNA in the anti-hypertrophic effects of Trx1, total RNA was extracted from Tg-Trx1 hearts, enriched for small RNA, and analyzed by microarrays of mature rodent microRNA. Both miR1 and miR98 are upregulated in the Tg-Trx1 heart. Since miR1 negatively regulates CH, we here examined the role of miR98 in regulation of CH. qRT-PCR showed that miR98 is upregulated in both Tg-Trx1 and Trx1 adenovirus transduced cardiac myocytes (CM) (+15 fold, 3.2 fold). Adenovirus-mediated expression of miR98 in CM reduced cell size both at basal levels (−14%, p&lt;0.05) and in response to AII (−20%, p&lt;0.05), suggesting that miR98 negatively regulates CH. Cyclin D2 (ClnD2) is one of the predicted targets of miR98 and has been shown to play an essential role in mediating AII-induced CH. AII significantly upregulated ClnD2 protein (+34%, p&lt;0.05) at 3 to 6 h in CM. Overexpression of Trx1 downregulated, while expression of DN-Trx1 augmented the AII-induced increase in ClnD2 in vitro (+17.4%, +45.3 %). Similarly ClnD2 was downregulated in Tg-Trx1 and upregulated in Tg-DN-Trx1 mouse hearts (−70.2%, +86.7%). Expression of miR98 in CM decreased expression of ClnD2 by 27% as determined by immunoblotting and reduced nuclear immunostaining of ClnD2, suggesting that both Trx1 and miR98 negatively regulate ClnD2 in CM. These results suggest that Trx1 upregulates miR98, which in turn inhibits CH, possibly through negative regulation of ClnD2 in CM.
Abstract 12811: Lipid-Altering Efficacy and Safety Profile of Co-Administered Extended Release Niacin/Laropiprant and Simvastatin Versus Atorvastatin in Patients With Mixed Hyperlipidemia
Authors: Fabian Chen, Darbie Maccubbin, Lizhen Yan, Erluo Chen, Christine Mccrary Sisk, James Mckenney, Michael Davidson, Peder Blomqvist
Journal: Circulation (2011)
Breast Cancer Racial Gap Examined
Authors: Brian Vastag
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1306: Late-outgrowth Endothelial Cells Attenuate Intimal Hyperplasia Contributed By Mesenchymal Stem Cells After Vascular Injury
Authors: Chao Hung Wang, Wen-Jin Cherng, I-Chang Hsieh, Ning-I Yang, Chi-Hsiao Yeh
Journal: Circulation (2007)

Objectives: Mesenchymal stem cells (MSCs) from the bone marrow (BM) are pluripotent and have the capacity to differentiate into cardiomyocytes, endothelial cells (ECs), and smooth muscle cells (SMCs). Currently, MSCs are one of a number of cell types undergoing extensive investigation for cardiac regeneration therapy. However, it has not yet been determined whether this cell therapy also substantially contributes to vascular remodeling of diseased vessels, such as in intimal hyperplasia. Methods and Results: Human MSCs and a variety of progenitor and vascular cells were used for in vitro and in vivo adhesion experiments. To test the contribution of MSCs to intimal hyperplasia, MSCs from eGFP mice were injected via the tail vein of wild-type littermates after femoral artery wire injury. A model of direct BM transplantation of eGFP MSCs into the tibias of irradiated wild-type littermates was also conducted. Wire-induced vascular injury mobilized MSCs into the circulation. Compared to human aortic SMCs, MSCs exhibited a 2.8-fold increase in the adhesion capacity in vitro ( p &lt; 0.001), and a 6.3-fold increase in vivo ( p &lt; 0.001). In all animal models, immunostaining showed that a significant amount of eGFP MSCs contributed to intimal hyperplasia after vascular injury. Furthermore, MSCs were able to differentiate into cells of endothelial or smooth muscle lineage on the injured vessel wall. Co-culture experiments demonstrated that late-outgrowth ECs guided MSCs to differentiate towards an endothelial lineage through a paracrine effects rather than direct cell-cell interactions. In vivo , cell therapy with late-outgrowth ECs significantly attenuated the thickness of the neointima contributed by MSCs (intima/media ratio, from 3.2 ± 0.4 to 0.4 ± 0.1, p &lt; 0.001). Conclusions: This study raises concerns about the detrimental effects of stem cell therapy on injured vessel remodeling. Tissue regeneration therapy with MSCs or cell populations containing MSCs requires a strategy to attenuate the high potential of MSCs to develop intimal hyperplasia on diseased vessels.
Choline acetyltransferase in schizophrenia
Authors: C N Karson, M F Casanova, J E Kleinman, W S Griffin
Journal: American Journal of Psychiatry (1993)

To test the hypothesis that schizophrenia involves altered cholinergic tone in the pons, the authors studied post-mortem brain tissue from subjects with schizophrenia.The authors used Western immunoblot to measure the concentration of choline acetyltransferase, an acetylcholine synthesizing enzyme, in the post-mortem brain tissue of 25 schizophrenic subjects and 28 nonschizophrenic comparison subjects. They also measured the concentration of glial fibrillary acidic protein, a protein from astrocytes, to examine the question of neurodegeneration.The pontine choline acetyltransferase concentrations of the schizophrenic subjects were 46% lower than those of comparison subjects, a significant difference. Glial fibrillary acidic protein concentrations did not differ between the two groups.The lower concentration of choline acetyltransferase in the pontine tegmentum of schizophrenic subjects compared with comparison subjects suggests involvement of pontine cholinergic neurons in schizophrenia.
A Primer on Immunologic Disorders.
Authors: Heinz J. Wittig, William A. Welton, Robert Burrell
Journal: Annals of Internal Medicine (1970)

Book Reviews1 November 1970A Primer on Immunologic Disorders.https://doi.org/10.7326/0003-4819-73-5-878_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail AbstractThe publisher has modestly announced that this very timely primer has been prepared for students and practitioners that require a brief outline on current concepts of immunologic disorders and their application to clinical management. I like the presentation. It is an excellent demonstration of collective intellectual interdisciplinary exchange among the pediatric allergist, dermatologist, and immunologist. It migth appear that the omission of the internist-allergist from authorship would provide gaps in the material presented; there are none. The combined efforts of the authors have produce a readable, informative primer on immunologic disorders with emphasis on the developments in research and their This content is PDF only. To continue reading please click on the PDF icon. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCarbohydrates 1 November 1970Volume 73, Issue 5 Page: 878-878 Keywords Allergy and immunology ePublished: 1 December 2008 Issue Published: 1 November 1970 PDF downloadLoading ...
Toll-like Receptor 4 Polymorphisms and Aspergillosis
Authors: Stuart M. Levitz, Shmuel Shoham, John D. Cleary
Journal: New England Journal of Medicine (2009)

However, there is another possible explana -tion for the findings that should be considered. During much of the period of the study, trans -plant recipients with febrile neutropenia that was unresponsive to antibiotics received amphotericin B. This is significant because conventional and lipid formulations of amphotericin B activate phagocytic cells by stimulating toll-like receptor 2 (TLR2) and TLR4 to release proinflammatory cy -tokines and chemokines.
Phase I trial of vatalanib (PTK787) in combination with standard radiation and temozolomide in patients with newly diagnosed glioblastoma
Authors: T. Batchelor, A. F. Eichler, S. R. Plotkin, J. Drappatz, P. Wen, A. G. Sorensen, E. Gerstner
Journal: Journal of Clinical Oncology (2009)

2035 Background: Anti-vascular endothelial growth factor (VEGF) agents are hypothesized to work synergistically with chemotherapy and radiation (RT). Vatalanib (MW 347, T1/2 4.6 h) is an oral, pan-VEGFR tyrosine kinase inhibitor that has shown activity in patients with recurrent glioblastoma. Methods: This phase I study was designed to determine the maximal tolerated dose of vatalanib in combination with RT and TMZ for patients with newly diagnosed GBM who were taking enzyme-inducing anti-epileptic drugs. RT and TMZ were administered at standard doses. Vatalanib was initiated 5 days prior to the start of RT and continued daily until tumor progression, unacceptable toxicity or a maximum of up to 12 cycles of post-RT TMZ. Cohorts of 3 patients were treated during RT and TMZ at doses of 250mg daily, 250mg BID, or 500mg BID of vatalanib. Following the completion of RT, patients were treated with vatalanib 750mg BID for the remainder of the study. Results: Nineteen patients were enrolled of which 17 took 5 or more days of vatalanib (1 patient withdrew consent prior to start of vatalanib and 1 withdrew consent after only 1 dose). The median age was 58 and the median KPS was 90. Eight patients had a diagnostic biopsy only. The MTD has not been reached. Potentially related grade 3–4 toxicities included elevated transaminases (2 patients), thrombocytopenia (1 patient), leukopenia (1 patient), neutropenia (1 patient), depressed level of consciousness (1 patient), and fatigue (1 patient). Only 1 patient suffered an asymptomatic intracerebral hemorrhage and no patient experienced wound dehiscence or infection. Five patients remain on vatalanib and the median follow-up for all patients is 6.5 months. Seven patients have died. The best responses for the 13 patients who completed combination RT/TMZ/vatalanib was 2 PR, 7 SD, and 2 PD. Two patients were clinically stable with biopsy proven pseudoprogression. Median PFS is 18.4+ months and OS has not been reached. Conclusions: Vatalanib is safe and well tolerated when added to standard RT and TMZ. The MTD has not been reached and dose escalation continues in this population of patients on enzyme inducing anti-epileptic drugs. [Table: see text]
9-Month Clinical, Angiographic, and Intravascular Ultrasound Results of a Prospective Evaluation of the Axxess Self-Expanding Biolimus A9-Eluting Stent in Coronary Bifurcation Lesions
Authors: Stefan Verheye, Pierfrancesco Agostoni, Christophe L. Dubois, Joseph Dens, John Ormiston, Stephen Worthley, Brett Trauthen, Takao Hasegawa, Bon-Kwon Koo, Peter J. Fitzgerald, Roxana Mehran, Alexandra J. Lansky
Journal: Journal of the American College of Cardiology (2009)
Abstract 18059: Papillary Muscle Abnormalities in Apical Hypertrophic Cardiomyopathy and Their Association with Mid-Ventricular Obstruction: Insignt from Cardiac Magnetic Resonance Imaging
Authors: Chi Young Shim, Woo-In Yang, Young Jin Kim, Min-Kyung Kang, Namsik Chung, Seung-Yun Cho, Jong-Won Ha
Journal: Circulation (2011)

Background Abnormal papillary muscles(PM) are often found in hypertrophic cardiomyopathy(HCM) and the significance relating left ventricular(LV) outflow obstruction has been identified. Mid-ventricular obstruction(MVO) can be found in apical HCM and accompanied by apical aneurysm and ventricular tachycardia. We sought to investigate PM structures including numbers, thickness, insertion site and their association with MVO in apical HCM. Methods In 44 patients(30 men, age 57±8 yrs) with apical HCM, cardiac magnetic resonsnce was performed to characterize PM morphology. PM numbers, maximal PM thickness in diastole, and their insertion site on LV were evaluated. Patients with isolated asymmetric apical hypertrophy were classified as a pure type, and those with coexistent hypertrophy of the interventricular septum as a mixed type. MVO were examined using Doppler echocardiography and diagnosed when the systolic peak flow velocity at the mid-ventricle was≥2.5 m/s. Subjects were divided into 2 groups according to the presence of MVO; Group I(n=28): MVO(-), Group II(n=15): MVO(+). Results The mixed type was more prevalent(54 vs 93%, p=0.014) and posterior wall thickness at mid LV was higher(10.2±1.8 vs 12.9±2.1, p&lt;0.001) in group II compared with group I. Apical aneurysm was found in 3 patients in group II. Group II showed higher PM numbers(2.7±0.8 vs 3.3±0.8, p=0.070) and maximal thickness(8.7±0.9 vs 10.8±1.5, p=0.045). PMs were displaced closer to the LV apex(displaced apically: 68 vs 93%, p=0.042) in almost of group II patients. There was no significant difference in heart rate between two groups. Conclusion In apical HCM, patients with MVO showed different PM structures and displacement than those without MVO. Increased number of PMs and their apical displacement can be one of contributors of MVO. Combined with the LV morphologic type, the assessement of PM morphology would be important to predict the development of MVO and its subsequent outcomes in apical HCM.
Handbook of Sleep Medicine.
Authors: John M. Shneerson
Journal: Thorax (2001)

Myositis associated with graft-versus-hostdisease (GVHD) typically presents with proximal muscle weakness, myalgias, and a raised creatinine phosphokinase (CPK) level.We report a case of a 51 year old man who developed respiratory muscle weakness five years after an allogeneic bone marrow transplant for multiple myeloma.His symptoms included tachypnoea, abdominal paradox, and orthopnoea.Pulmonary function tests revealed diminished vital capacity and maximal inspiratory and expiratory pressures.Serum CPK levels were raised and a peripheral muscle biopsy specimen was consistent with GVHD.He improved with immunosuppressive therapy.
The Human Colon: An Experimental Study Based on Direct Observation of Four Fistulous Subjects
Authors: William J. Grace, Stewart Wolf, Harold G. Wolff
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4017: Automated Chart Abstraction Can Provide Highly Accurate Data Extraction For Clinical Quality Measures: Assessment of REMINDTM for CMS Heart Failure Measures
Authors: Trish Wilmes, Kim Bohy, Alexis Gilson, Sriram Krishnan, Romer Rosales, Maleeha Qazi, Stefan Niculescu, Farbod Rahmanian, William Landi, Bharat Rao
Journal: Circulation (2006)
Assessing positive and negative symptoms in children and adolescents
Authors: J H Fields, S Grochowski, J P Lindenmayer, S R Kay, D Grosz, R B Hyman, G Alexander
Journal: American Journal of Psychiatry (1994)

The purpose of this study was to test the reliability and validity of a new assessment instrument for positive and negative symptoms in severely disturbed children and adolescents (Kiddie-PANSS).The Positive and Negative Syndrome Scale for adult schizophrenia was modified through successive field trials on the basis of developmental characteristics of children and adolescents. The scale was then given to 34 inpatients (19 children, mean age = 9.35 years, and 15 adolescents, mean age = 14.33 years) with DSM-III-R diagnoses of schizophrenia, psychosis not otherwise specified, schizoaffective, affective, conduct, personality, and developmental disorders determined independently by child psychiatrists. All patients with schizophrenia were placed in the schizophrenic group, and all others were placed in a general inpatient group. The Kiddie-PANSS ratings were given by three trained child psychiatrists after a 30-35-minute structured interview. The Achenbach Child Behavior Checklist, the Scale for the Assessment of Positive Symptoms, and the Scale for the Assessment of Negative Symptoms were also administered in order to determine criterion-related association.Intraclass correlation coefficients revealed that all subscales and total psychopathology were reliably assessed among raters. The Kiddie-PANSS and Scale for the Assessment of Positive Symptoms/Scale for the Assessment of Negative Symptoms correlated with one another, indicating criterion-related association. Differences on measures of positive, negative, and general psychopathology, as measured by the Kiddie-PANSS, between the patients with schizophrenia and the general inpatient group were highly significant.The Kiddie-PANSS shows good interrater reliability and criterion-related validity. In a cohort of inpatient children and adolescents the scale successfully differentiated schizophrenic patients from nonschizophrenic patients.
Visceral Leishmaniasis
Authors: T A Moore
Journal: New England Journal of Medicine (1997)

本文报告陇南川北山区中华白蛉若干生物学观察的结果及其与人、犬内脏利什曼病的关系。中华白蛉为本区的优势种,具有野栖习性,发生季节自5月至10月,7月为高峰期,峰幅宽和持续时间长为其特点。我们对中华白蛉全季节的性营养周期变动作了观察和分析,指出它是阐明蛉口动力学、预报和预防疾病发生的重要指征。饲血测试表明中华白蛉吸犬血率为61.5%(198/322),当地犬感染内脏利什曼病是与当地中华白蛉吸犬血的习性密切相关。不同垂直高度中华白蛉的发育史比较观察,证明其发育期长短是受自然因素的严格制约。提高温度和增加光照并不能使滞育幼虫提前解除滞育;相反,在自然室温和自然光下饲养的滞育幼虫是实验室饲养越冬幼虫的理想方法。中华白蛉人工感染试验和自然感染调查数据表明,本区中华白蛉是传播人、犬内脏利什曼病的唯一媒介。同时证明本区存在黑热病的自然疫源地。调查说明了媒介生态习性与其传病有直接的关系,并可表达在相互间传播,它们是怎样起着不同的传播作用,因此,研究媒介的生物学及其传病的各种因素有重要的意义。
Community leg ulcer clinics
Authors: R Sheehan-Dare
Journal: BMJ (1996)

skin cancer and melanoma in particular.4In view of such evidence the risk-benefit ratio of using ultraviolet A sunbeds should be re-examined, and the medical profession should be more critical of sunbed salons that operate purely for financial gain.The Health Education Board in Scotland and the Department of Health are unequivocal in their advice that sunbeds should not be used for cosmetic tanning.Disturbingly, a considerable number of sunbeds are still operated by local councils, often in the incongruous setting of a health and fitness suite in a leisure centre.The promotion of machines whose only function is to produce radiation damage to the skin, which may ultimately promote skin cancer, should play no part in the operational policy of modern local councils professing to have the best interest of their constituents at heart.Councils may argue that they are catering for a demand for sunbeds by the public, but this demand is led by ignorance and should be rejected.Caradon Dis- trict Council removed the sunbeds from one of its leisure centres last February, and Dumfries and Galloway Council removed the sunbeds in five locations from south west Scotland in June.These councils are to be congratulated for putting the health of their constituents ahead of financial gain.Now that a precedent has been set, all local authorities should seriously consider closing their sunbed facilities.Doctors, and dermatolo- gists in particular, should pressure them to do so.
Panhandle Polymerase Chain Reaction Amplifies MLL Genomic Translocation Breakpoint Involving Unknown Partner Gene
Authors: Carolyn A. Felix, Caroline S. Kim, Maureen D. Megonigal, Diana J. Slater, Douglas H. Jones, Nancy B. Spinner, Tammy Stump, Matthew R. Hosler, Peter C. Nowell, Beverly J. Lange, Eric F. Rappaport
Journal: Blood (1997)
Prognostic and Bioepidemiologic Implications of Papillary Fibroelastomas
Authors: Syahidah S. Tamin, Joseph J. Maleszewski, Christopher G. Scott, S.K. Khan, William D. Edwards, Charles J. Bruce, Jae K. Oh, Patricia A. Pellikka, Kyle W. Klarich
Journal: Journal of the American College of Cardiology (2015)