tbuckley/cabot-search huggingface dataset:
Surface densities of diaphragmed fenestrae and transendothelial channels in different murine capillary beds.
Authors: A JMilici, NL'Hernault, G EPalade
Journal: Circulation Research (1985)

Fenestrated capillaries are provided with two types of regular discontinuities: fenestrae with negatively charged diaphragms, and transendothelial channels fitted with two diaphragms, of which the luminal one is uncharged. These structures are expected to affect macromolecular exchanges on the basis of size and charge. We have detected variations in the surface density of fenestrations and transendothelial channels (normalized to 1 micron of capillary endothelial profiles in sections) in selected areas of different murine organs, i.e., kidney cortex, duodenal mucosa, and exocrine pancreas. The survey was limited to endothelial segments less than or equal to 400 nm thick, and covered a total length of endothelial profiles of 1180 microns, 730 microns, and 1189 microns in the exocrine pancreas, intestinal mucosa, and kidney cortex, respectively. At least 1000 transendothelial openings were recorded by scoring for easily recognizable fenestrations, transendothelial channels, and unknowns, the latter represen...
Abstract BS01-1: Genetic and non-genetic mechanisms contribute to longterm clonal growth dynamics and therapy resistance
Authors: JE Dick
Journal: Cancer Research (2013)

Abstract The cellular and molecular basis for intra-tumoral heterogeneity is poorly understood. Tumor cells can be genetically diverse due to mutations and clonal evolution resulting in intra-tumoral functional heterogeneity. Often proposed as mutually exclusive, cancer stem cell (CSC) models postulate that tumors are cellular hierarchies sustained by CSC heterogeneity due to epigenetic differences (i.e. long term tumor propagation only derives from CSC). Two lines of evidence support the CSC model in leukemia. We have recently developed gene signatures specific to either AML LSC or normal HSC and found they share a set of genes that define a common stemness program. Only these stem cell related gene signatures were significant independent predictors of patient survival in large clinical databases. Thus, determinants of stemness influence clinical outcome of AML across a spectrum of mutations indicating that many genetic abnormalities coalesce around stem cell properties. Second, we have carried out a series of combined genetic and functional studies of the LSC from either B-ALL or AML that point to commonalities between clonal evolution and CSC models of cancer. LSC from diagnostic patient samples were genetically diverse and reconstruction of their genetic ancestry showed that multiple LSC subclones were related through a complex branching evolutionary process. The discovery that specific genetic events influence L-IC frequency and that genetically distinct L-IC evolve through a complex evolutionary process indicates that genetic and functional heterogeneity are highly inter-related. Finally, we have also begun to study paired diagnostic (Dx) and relapse (Rx) samples and found that rare Dx subclones are chemotherapy resistant and become enriched at Rx. Collectively, our study points to the need to develop therapies that effective target all genetic subclones present in a tumor and also ensure that cells possessing stemness properties are eliminated to prevent further evolution and recurrence. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr BS01-1.
Chromoendoscopy Using Blue Laser Imaging in the Prediction of Submucosal Invasion In Colorectal Neoplastic Lesions
Authors: J Estorninho, E Gravito-Soares, P Amaro, P Figueiredo
Journal: Endoscopy (2021)

Aims Endoscopic diagnosis of submucosal invasion allows an optimized treatment strategy for colorectal polyps. Virtual chromoendoscopy, namely with Narrow Band Imaging, can help to predict the presence and depth of submucosal invasion.Data regarding Blue Laser Imaging (BLI) for predicting deep submucosal invasive carcinoma (dSMC) are still missing. The present research aimed to evaluate the diagnostic performance of endoscopic classifications when using BLI.
Abstract 12032: Implantable Loop Recorders: Sensitive but Not Specific
Authors: Mustafa AlQaysi, Navid Berenji, Jennifer Logan, Stacy Saldivar, Manoj Panday, Auroa Badin, Dhanunjaya Lakkireddy, Arun Sridhar, Jayasree Pillarisetti
Journal: Circulation (2019)

Introduction: Implantable loop recorders (ILRs) are useful long-term monitors to detect arrhythmias in real time with remote monitoring. However, false positive (FP) alerts can add to significant d...
Role of central catecholamines on the potentiation of the baroreflex produced with vasopressin. A study using 6-hydroxydopamine.
Authors: K PUndesser, A JTrapani, W WMorgan, V SBishop
Journal: Circulation Research (1986)

This study compares the effect of arginine-vasopressin and phenylephrine on renal sympathetic nerve activity, arterial pressure, and heart rate in vehicle- and intraventricular 6-hydroxydopamine-treated conscious rabbits. In addition, this study examines the involvement of forebrain structures on these variables. In vehicle-treated rabbits, compared to phenylephrine, vasopressin produces a greater decrease in renal sympathetic nerve activity and heart rate for a given increase in pressure. After administration of intraventricular 6-hydroxydopamine, the responses produced with vasopressin are similar to those produced with phenylephrine. Analysis of catecholamine content in the nucleus of the solitary tract, parabrachial nucleus, area postrema, and spinal cord indicates that the only regions of significant catecholamine depletion are in the nucleus of the solitary tract and the spinal cord. Transection at the mid-collicular level does not alter significantly the responses of vasopressin or phenylephrine on...
Overnight Oximetry–derived Pulse Rate Variability Predicts Stroke Risk in Patients with Obstructive Sleep Apnea
Authors: Abdelkebir Sabil, Chloé Gervès-Pinquié, Margaux Blanchard, Mathieu Feuilloy, Wojciech Trzepizur, François Goupil, Thierry Pigeanne, Emmanuel Oger, Jean-Marc Girault, Frédéric Gagnadoux, Nicole Meslier, Christine Person, Pascaline Priou, Olivier Molinier, Audrey Paris
Journal: American Journal of Respiratory and Critical Care Medicine (2021)

"Overnight Oximetry–derived Pulse Rate Variability Predicts Stroke Risk in Patients with Obstructive Sleep Apnea." American Journal of Respiratory and Critical Care Medicine, 204(1), pp. 106–109
Extrahepatic Manifestations of Hepatitis C Virus Infection
Authors: Jeffrey L. Pollock
Journal: Annals of Internal Medicine (1996)

Letters15 August 1996Extrahepatic Manifestations of Hepatitis C Virus InfectionJeffrey L. Pollock, MDJeffrey L. Pollock, MDChurchville, PA 18966Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-4-199608150-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Two extrahepatic manifestations of HCV should be added to those described in the recent review by Gumber and Chopra [1].A significant prevalence of HCV markers (5% to 20%) has been reported in several series of patients with polyarteritis nodosa [2-4]. This finding suggests that HCV may occasionally cause this disorder. Cases of autoimmune thrombocytopenic purpura have been noted in patients with chronic hepatitis C. Serum HCV antibodies have been detected in 19% of 112 patients with autoimmune thrombocytopenic purpura [5].Thus, HCV markers should be monitored in patients with polyarteritis nodosa and autoimmune thrombocytopenic purpura.References1. Gumber SC, Chopra S. Hepatitis C: a multifaceted disease. Review of extrahepatic manifestations. Ann Intern Med. 1995; 123:615-20. Google Scholar2. Cacoub P, Lunel-Fabiani F, Le Thi Huong D. Polyarteritis nodosa and hepatitis C virus infection. Ann Intern Med. 1992; 116:605-6. Google Scholar3. Deny P, Bonacorsi S, Guillevin L, Quint L. Association between hepatitis C virus and polyarteritis nodosa. Clin Exp Rheumatol. 1992; 10:319-24. Google Scholar4. Carson CW, Conn DL, Czaja AJ, Wright TL, Brecher ME. Frequency and significance of antibodies to hepatitis C virus in polyarteritis nodosa. J Rheumatol. 1993; 20:304-9. Google Scholar5. Silva M, Li X, Cheinquer H, et al. HCV-associated idiopathic thrombocytopenic purpura (ITP) [Abstract]. Gastroenterology. 1992; 102:A889. Google Scholar Author, Article, and Disclosure InformationAffiliations: Churchville, PA 18966 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHepatitis C virus-induced leuko-thrombocytopenia and haemolysis 15 August 1996Volume 125, Issue 4Page: 345KeywordsAntibodiesChronic hepatitis CHepatitis C virusIdiopathic thrombocytopenic purpuraInfectious hepatitis Issue Published: 15 August 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Changes in cholesterol and triglyceride as predictors of ischemic heart disease in men.
Authors: R JGlynn, BRosner, J ESilbert
Journal: Circulation (1982)

We examined the relation of longitudinal changes in cholesterol and triglyceride to the subsequent development of heart disease. The data were from 1437 participants of the Normative Aging Study, a prospective study of men from the Boston area who were free of ischemic heart disease on two examinations approximately 5 years apart. Forty-four had symptoms or ECG findings of ischemic heart disease after their second but before their third examination, a period of 3-5 years. The risk of heart disease was studied using a multiple logistic risk model that took into account smoking and other risk factors. Changes in cholesterol and triglyceride levels between Exams 1 and 2, when corrected for regression to the mean, were better predictors of heart disease incurred between Exams 2 and 3 than initial levels of cholesterol, triglyceride or systolic blood pressure. When two age groups (28-52 years and 53-85 years) were considered, changes were important predictors in each age group. These findings suggest the impor...
<i>MMP12</i>, Lung Function, and COPD in High-Risk Populations
Authors: Paul T. Elkington, Graham S. Cooke
Journal: New England Journal of Medicine (2010)

Hunninghake et al. (Dec. 31 issue)1 report an association between single-nucleotide polymorphisms (SNPs) in MMP12 and lung function in children with asthma and in adults who smoke, as well as an association with a reduced risk of chronic obstructive pulmonary disease (COPD) in adult smokers. However, a statistical genetic association may be observed when the implicated SNP is in strong linkage disequilibrium with another ungenotyped, but “causative,” SNP, often one that is in close proximity to the implicated SNP. To determine whether their findings could be explained by linkage disequilibrium, the authors present data for neighboring genes MMP3 and MMP13. Surprisingly, the authors did not present data for MMP1 (encoding interstitial collagenase), which is adjacent to MMP3 on chromosome 11 and is closer to MMP12 than is MMP13. Moreover, MMP1 has been strongly implicated in the pathogenesis of both COPD2 and asthma.3 It is a testable hypothesis that MMP1 encodes the protease that drives lung pathology. The association described by Hunninghake et al. could be attributable to SNPs within MMP1.
Different reactivity and structure of the prestenotic and poststenotic aorta in human coarctation. Implications for baroreceptor function.
Authors: JSehested, UBaandrup, EMikkelsen
Journal: Circulation (1982)

In eight humans with coarctation, fresh aortic tissue was examined pharmacodynamically. In four of these patients, and in 12 additional patients, the aorta above and below the coarctation was studied morphologically and compared with eight control aortas. By in vitro stimulation with potassium (127 mM), noradrenaline (18 microM), and prostaglandin F2 alpha (28 microM), postcoarctational aortic ring preparations showed a significantly greater contractility than precoarctational rings (p less than 0.05). Volumetric analysis showed significantly more collagen (P less than 0.01) and les smooth muscle mass (p less than 0.01) in the aorta above than below the coarctation. No significant differences were found between sections from the arch and distal to the ligamentum arteriosum in the normal aortas. We conclude that the precoarctational aortic wall is more rigid than the postcoarctational wall. This may influence baroreceptors in the upper vascular bed in such a way as to tolerate a higher pressure. This would...
Histamine H1 receptor antagonists inhibit autoregulation of renal blood flow in the dog.
Authors: R OBanks, E WInscho, E DJacobson
Journal: Circulation Research (1984)

Histamine H1 and H2 receptors are present in the canine renal circulation. We have examined the effects of H1 and H2 receptor antagonists on autoregulation of renal blood flow in the dog. Renal arterial pressure was reduced in a step-wise fashion to 80 mm Hg by means of an adjustable aortic clamp positioned above the left renal artery. Infusion of H2 antagonists, cimetidine or ranitidine, into the left renal artery at 10(-5) mol/min had no effect on autoregulation of renal blood flow or on the reactive hyperemia that occurred when the aortic constriction was released. By contrast, intrarenal infusion of 10(-5) mol/min chlorpheniramine, an H1 receptor antagonist, reversibly attenuated reactive hyperemia and the ability of the kidney to autoregulate renal blood flow. Similar results were obtained with other, chemically dissimilar H1 antagonists (terfenadine, diphenhydramine, and pyrilamine). The effects of chlorpheniramine on autoregulation of glomerular filtration rate also were evaluated. Before chlorphen...
A model of the ventricular cardiac action potential. Depolarization, repolarization, and their interaction.
Authors: C HLuo, YRudy
Journal: Circulation Research (1991)

A mathematical model of the membrane action potential of the mammalian ventricular cell is introduced. The model is based, whenever possible, on recent single-cell and single-channel data and incorporates the possibility of changing extracellular potassium concentration [K]o. The fast sodium current, INa, is characterized by fast upstroke velocity (Vmax = 400 V/sec) and slow recovery from inactivation. The time-independent potassium current, IK1, includes a negative-slope phase and displays significant crossover phenomenon as [K]o is varied. The time-dependent potassium current, IK, shows only a minimal degree of crossover. A novel potassium current that activates at plateau potentials is included in the model. The simulated action potential duplicates the experimentally observed effects of changes in [K]o on action potential duration and rest potential. Physiological simulations focus on the interaction between depolarization and repolarization (i.e., premature stimulation). Results demonstrate the impor...
A novel protein encoded by circMAPK1 inhibits progression of gastric cancer by suppressing activation of MAPK signaling
Authors: Tianlu Jiang, Yiwen Xia, Jialun Lv, Bowen Li, Ying Li, Sen Wang, Zhe Xuan, Li Xie, Shengkui Qiu, Zhongyuan He, Linjun Wang, Zekuan Xu
Journal: Molecular Cancer (2021)

Abstract Background A novel type of noncoding RNA, circRNA has been reported to participate in the occurrence and development of diseases through many mechanisms. The MAPK pathway is a common signal transduction pathway involved in cell proliferation, inflammation and apoptosis and plays a particularly important role in cancers. However, the role of circRNAs related to the MAPK pathway in gastric cancer has not been explored. Methods A bioinformatics analysis was performed to profile and identify the circRNAs involved in the MAPK pathway in gastric cancer. The tumor-suppressive role of circMAPK1 was confirmed both in vitro and in vivo. Mass spectrometry, Western blot and immunofluorescence staining assays were used to validate the existence and expression of MAPK1–109aa. The molecular mechanism of circMAPK1 was investigated by mass spectrometry and immunoprecipitation analyses. Results In this study, we identified that circMAPK1 (hsa_circ_0004872) was downregulated in gastric cancer tissues compared with adjacent normal tissues. Importantly, lower circMAPK1 expression predicted poor survival in GC patients. CircMAPK1 inhibited the proliferation and invasion of gastric cancer cells in vitro and in vivo. Next, we found that circMAPK1 encoded a novel protein with 109 amino acids in length. Through a series of functional experiments, we confirmed that circMAPK1 exerted a tumor-suppressing effect via the encoded protein MAPK1–109aa. Mechanistically, the tumor suppressor MAPK1–109aa inhibited the phosphorylation of MAPK1 by competitively binding to MEK1, thereby suppressing the activation of MAPK1 and its downstream factors in MAPK pathway. Conclusions Our study revealed that circMAPK1 inhibits the malignant biological behavior of gastric cancer cells through its encoded protein MAPK1–109aa. More importantly, circMAPK1 is a favorable predictor for gastric cancer patients and may provide a new therapeutic target in the treatment of gastric cancer.
Early postoperative reduction of monoclonal antimyosin antibody uptake is associated with absent rejection-related complications after heart transplantation.
Authors: MBallester, DObrador, ICarrió, CMoya, J MAugè, RBordes, VMartí, IBosch, LBernà-Roqueta, MEstorch
Journal: Circulation (1992)

BACKGROUNDDetection and treatment for rejection after transplantation are based on the identification of myocyte damage upon endomyocardial biopsy. Noninvasive detection of such damage is possible with 111In-labeled monoclonal antimyosin antibodies (MAA). Although the presence and degree of MAA uptake parallels the rejection activity detected by biopsy, the relation between the degree of uptake and the occurrence of severe rejection-related complications has not been previously assessed.METHODS AND RESULTSTwo hundred forty-seven MAA studies were performed coinciding with biopsies in 52 patients 1-71 months after transplantation. A heart-to-lung ratio (HLR) was used as a measure of relative MAA uptake, with an HLR of 1.55 discriminating normal from abnormal studies. Of the 247 antimyosin studies, 149 coincided with absent, 38 with mild, and 60 with moderate rejection at biopsy. HLR was 1.68 +/- 0.27, 1.79 +/- 0.22, and 1.91 +/- 0.33 in the three biopsy groups, respectively (p less than 0.0001). Two hundred...
26P Analysis of prognostic and predictive factors of response in squamous cell carcinoma using NGS techniques
Authors: P. Cruz Castellanos, L. Gutierrez Sainz, O. Higuera Gomez, C. Antolin, R. Rosas Alonso, I. Ibañez, B. Castelo, X. Mielgo Rubio, J. De Castro Carpeno
Journal: Journal of Thoracic Oncology (2021)
Faecal microbiota transplantation in clinical practice
Authors: Giovanni Cammarota, Gianluca Ianiro, Antonio Gasbarrini
Journal: Gut (2017)

Faecal microbiota transplantation in clinical practiceWe thank Dr Terveer and colleagues for their correspondence on our faecal microbiota transplantation (FMT) consensus report. 1 2 Their comments enrich the discussion on this topic, which was not fully developed in the paper because of word count limitations.Our report aimed at providing evidence-based statements on the application of FMT in clinical practice.Thus, consensus experts were chosen according to their scientific profiles in the field of FMT (including the various procedural steps) and its possible clinical application (IBD, IBS, metabolic syndrome, etc).The experts were also representative of the different European countries.
Factors that affect the reproducibility of measurements of left ventricular function from first-pass radionuclide ventriculograms.
Authors: D SDymond, AElliott, DStone, GHendrix, RSpurrell
Journal: Circulation (1982)

To examine which factors affect the reproducibility of ejection fraction (EF), pulmonary transit time (PTT) and segmental wall motion assessed from first-pass radionuclide angiograms (FPRA), 32 patients who had FPRA were randomized for site of injection of isotope (right or left arm) and projection (right or left anterior oblique [RAO or LAO]). The quality of injected bolus was measured from the full width at half maximum (FWHM) of the bolus time-activity curve in the superior vena cava. All patients had two sequential studies on each of two consecutive days, and each study was analyzed independently by two observers. For EF, inter- and intraobserver correlations ranged from 0.94-0.98. EF was higher in the RAO than the LAO projection (mean 47.4% vs 40.3%, p less than 0.001), but neither injection site nor bolus FWHM affected the results. For PTT, interobserver correlations ranged from 0.75-0.93 and intraobserver correlations from 0.61-0.85. Variability in PTT was large, and inter- and intraobserver variab...
Carotid sinus hypersensitivity: evaluation of the vasodepressor component.
Authors: AAlmquist, CGornick, WBenson, ADunnigan, D GBenditt
Journal: Circulation (1985)

The basis of the vasodepressor response in patients with carotid sinus hypersensitivity (CSH) is unknown, and prevention of recurrent vasodepressor-induced hypotension in these patients has not been possible. In this study we assessed the effectiveness of atrioventricular sequential pacing and pharmacologic interventions in the prevention of carotid sinus massage (CSM)-induced vasodepressor responses in eight patients with CSH. Maintenance of constant heart rate (80 beats/min) and atrioventricular synchrony (atrioventricular interval 150 msec) with sequential pacing did not significantly alter mean CSM-induced fall in systolic pressure (CSM control, -60 +/- 12 mm Hg vs CSM with atrioventricular sequential pacing, -48 +/- 19 mm Hg). Similarly, neither pharmacologic muscarinic blockade nor combined muscarinic and beta-adrenergic blockade significantly attenuated CSM-induced fall in systolic pressure (CSM with atropine, -43 +/- 16 mm Hg; CSM with atropine plus propranolol, -47 +/- 18 mm Hg; both p = NS vs at...
Autoradiographic characterization of beta-adrenergic receptor subtype in the canine conduction system.
Authors: K HMuntz
Journal: Circulation Research (1992)

It has been hypothesized, based on physiological evidence, that there is a greater proportion of beta 2-adrenergic receptors on the myocytes of the conduction system when compared with the working myocardium. The purpose of these studies was to examine beta-adrenergic receptor subtype in the conduction system of the dog by using the technique of coverslip autoradiography. Scintillation studies of [125I]pindolol binding to ventricular sections demonstrated that binding was saturable (dissociation constant of 116 pM), had the correct order of potency for a beta-receptor, and was stereoselective. Both betaxolol (beta 1-selective) and ICI-118,551 (beta 2-selective) competition curves fit a two-site model in nonlinear curve-fitting analyses (78% beta 1-receptors). Autoradiographic studies determined that the myocytes of the sinoatrial node had approximately twice as many autoradiographic grains as the surrounding atrial myocytes. The myocytes of the atrioventricular bundle had a number of grains similar to the...