tbuckley/cabot-search huggingface dataset:
The 2021 report of the Lancet Countdown on health and climate change: code red for a healthy future
Authors: Marina Romanello, Alice McGushin, Claudia Di Napoli, Paul Drummond, Nick Hughes, Louis Jamart, Harry Kennard, Pete Lampard, Baltazar Solano Rodriguez, Nigel Arnell, Sonja Ayeb-Karlsson, Kristine Belesova, Wenjia Cai, Diarmid Campbell-Lendrum, Stuart Capstick, Jonathan Chambers, Lingzhi Chu, Luisa Ciampi, Carole Dalin, Niheer Dasandi, Shouro Dasgupta, Michael Davies, Paula Dominguez-Salas, Robert Dubrow, Kristie L Ebi, Matthew Eckelman, Paul Ekins, Luis E Escobar, Lucien Georgeson, Delia Grace, Hilary Graham, Samuel H Gunther, Stella Hartinger, Kehan He, Clare Heaviside, Jeremy Hess, Shih-Che Hsu, Slava Jankin, Marcia P Jimenez, Ilan Kelman, Gregor Kiesewetter, Patrick L Kinney, Tord Kjellstrom, Dominic Kniveton, Jason K W Lee, Bruno Lemke, Yang Liu, Zhao Liu, Melissa Lott, Rachel Lowe, Jaime Martinez-Urtaza, Mark Maslin, Lucy McAllister, Celia McMichael, Zhifu Mi, James Milner, Kelton Minor, Nahid Mohajeri, Maziar Moradi-Lakeh, Karyn Morrissey, Simon Munzert, Kris A Murray, Tara Neville, Maria Nilsson, Nick Obradovich, Maquins Odhiambo Sewe, Tadj Oreszczyn, Matthias Otto, Fereidoon Owfi, Olivia Pearman, David Pencheon, Mahnaz Rabbaniha, Elizabeth Robinson, Joacim Rocklöv, Renee N Salas, Jan C Semenza, Jodi Sherman, Liuhua Shi, Marco Springmann, Meisam Tabatabaei, Jonathon Taylor, Joaquin Trinanes, Joy Shumake-Guillemot, Bryan Vu, Fabian Wagner, Paul Wilkinson, Matthew Winning, Marisol Yglesias, Shihui Zhang, Peng Gong, Hugh Montgomery, Anthony Costello, Ian Hamilton
Journal: The Lancet (2021)
Deprogram and reprogram to solve the riddle of insulin resistance
Authors: Victoria L. Tokarz, Paul Delgado-Olguín, Amira Klip
Journal: Journal of Clinical Investigation (2021)

Skeletal muscle preeminently determines whole-body glycemia. However, the molecular basis and inheritable influence that drive the progression of insulin resistance to type 2 diabetes remain debated. In this issue of the JCI, Haider and Lebastchi report on their use of induced pluripotent stem cell-derived (iPSC-derived) myoblasts (iMyos) to uncover multiple phosphoproteomic changes that carried over from the human to the cell-culture system. In this system devoid of in vivo influences, the researchers annotated changes between the sexes and between the most and least insulin-sensitive quintiles of a healthy population (defined by steady-state blood glucose levels). Many phosphoproteomic differences were detected in the absence of insulin, revealing that changes in the basal landscape of cells determine the efficiency of insulin action. Basal and insulin-dependent deficiencies of iPSCs and iMyos likely involve genetic and epigenetic determinants that modulate insulin sensitivity.
IL-1 and IL-6 inhibition affects the neutralising activity of anti-SARS-CoV-2 antibodies in patients with COVID-19
Authors: Emanuel Della-Torre, Elena Criscuolo, Marco Lanzillotta, Massimo Locatelli, Nicola Clementi, Nicasio Mancini, Lorenzo Dagna
Journal: The Lancet Rheumatology (2021)
TCT-438 Transcatheter Versus Surgical Aortic Valve Replacement in Patients With Rheumatic Heart Disease
Authors: Mohammad Altujjar, Bishoy Abraham, Majd Jazaerly, Sara Samaan, Mohammed Mhanna, Azizullah Beran, Raid Saco, Bassent Botros, Philip Vendittelli, Sushruth Edla, Hassan Alkhawam, Thomas Lalonde, Bruce Andrus, Cynthia Taub
Journal: Journal of the American College of Cardiology (2021)
Hypoxia Reduction Sensitizes Refractory Cancers to Immunotherapy
Authors: Priyamvada Jayaprakash, Paolo Dario Angelo Vignali, Greg M. Delgoffe, Michael A. Curran
Journal: Annual Review of Medicine (2021)

In order to fuel their relentless expansion, cancers must expand their vasculature to augment delivery of oxygen and essential nutrients. The disordered web of irregular vessels that results, however, leaves gaps in oxygen delivery that foster tumor hypoxia. At the same time, tumor cells increase their oxidative metabolism to cope with the energetic demands of proliferation, which further worsens hypoxia due to heightened oxygen consumption. In these hypoxic, nutrient-deprived environments, tumors and suppressive stroma evolve to flourish while antitumor immunity collapses due to a combination of energetic deprivation, toxic metabolites, acidification, and other suppressive signals. Reversal of cancer hypoxia thus has the potential to increase the survival and effector function of tumor-infiltrating T cells, as well as to resensitize tumors to immunotherapy. Early clinical trials combining hypoxia reduction with immune checkpoint blockade have shown promising results in treating patients with advanced, metastatic, and therapeutically refractory cancers.
Comparison of Duration of Postapproval vs Pivotal Trials for Therapeutic Agents Granted US Food and Drug Administration Accelerated Approval, 2009-2018
Authors: Joshua D. Wallach, Reshma Ramachandran, Till Bruckner, Joseph S. Ross
Journal: JAMA Network Open (2021)

This cross-sectional study compares the duration of postapproval trials with that of the pivotal trials used as the basis for the US Food and Drug Administration's (FDA's) approval for all indications receiving accelerated approval from 2009-2018.
Abstract 13095: Persistent Impairment in Peripheral but Not Cerebral Vascular Function in Young Healthy Adults With Long-Term Symptoms From COVID-19
Authors: Damsara Nandadeva, Benjamin E Young, Brandi Y Stephens, Ann-Katrin Grotle, Rachel J Skow, Angela J Middleton, Florence P Haseltine, Paul J Fadel
Journal: Circulation (2021)

Vascular dysfunction and inflammation are precursors to cardiovascular disease (CVD). Notably, young adults who were symptomatic from COVID-19 during the acute phase of illness (within 4 weeks from diagnosis) have shown to exhibit peripheral vascular dysfunction. Importantly, many young adults report persistent symptoms from COVID-19 for several months, including cognitive difficulties. However, it remains unknown whether vascular dysfunction persists beyond the acute phase of COVID-19 in symptomatic young adults. We tested the hypothesis that peripheral and cerebral vascular function would be blunted in symptomatic (SYM) young adults who are beyond 4 weeks from a COVID-19 diagnosis, compared to asymptomatic adults (ASYM). Since COVID-19 causes inflammation that may negatively impact vascular function, we also hypothesized that serum hsCRP would be elevated in SYM compared to ASYM. We studied 15 otherwise healthy adults (age = 23 ± 1 years; mean ± SE) with a positive lab diagnosis of COVID-19. Eight were SYM (14 ± 1 weeks from diagnosis) while seven were ASYM (13 ± 2 weeks from diagnosis) at time of testing. Brachial artery flow-mediated dilation (FMD; duplex Doppler ultrasound) was performed, and macro- and microvascular function were quantified as FMD% and peak blood velocity after cuff release, respectively. Cerebral vasomotor reactivity (CVMR) was quantified as percent increase in middle cerebral artery blood velocity (transcranial Doppler ultrasound) to rebreathing induced hypercapnia. Serum hsCRP level was measured. FMD was lower in SYM (3.81 ± 0.60%) compared to ASYM (7.10 ± 0.94%, P = 0.010). Likewise, peak blood velocity after cuff release was lower in SYM (47 ± 3 cm/s vs. ASYM: 65 ± 8 cm/s, P = 0.037). However, CVMR was not different between the two groups (P = 0.91). Serum hsCRP was higher in SYM (3.4 ± 1.0 mg/L vs. ASYM: 0.7 ± 0.1 mg/L, P = 0.036). These preliminary results indicate that peripheral macro- and microvascular function remain blunted beyond the acute phase in young adults with persistent symptoms from COVID-19, whereas cerebral vascular function appears unaffected. The extent to which this sustained vascular impairment and elevated hsCRP contributes to increased CVD risk in these otherwise healthy young adults remains to be determined.
Optimizing Chemotherapy Choice in the Treatment of Advanced Pancreatic Cancer—It Is Complicated
Authors: Nguyen H. Tran, Tanios Bekaii-Saab
Journal: JAMA Network Open (2021)

Michael J. Raphael, MD, MSc; William Raskin, MD; Steven Habbous, PhD; Xiaochen Tai, MSc; Jaclyn Beca, MSc; Wei F. Dai, MSc; Jessica Arias; Leta Forbes, MD; Scott Gavura, MBA, RPh; James J. Biagi, MD; Craig C. Earle, MD, MSc; Kelvin K. W. Chan, MD, PhD
Final Long-Term Results from the Defifrance Registry Study: Efficacy and Safety of Defibrotide for the Treatment of Severe/Very Severe Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome after Hematopoietic Cell Transplantation
Authors: Mohamad Mohty, Didier Blaise, Regis Peffault De Latour, Myriam Labopin, Marie Detrait, Stephane Girault, Anne Huynh, Hélène Labussière-Wallet, Thierry Lamy, Delphine Lebon, Sébastien Maury, Cecile Renard, Kobby Asubonteng, Floriane Delaval, Ibrahim Yakoub-Agha, Jean-Hugues Dalle
Journal: Blood (2021)
Cytomegalovirus and Epstein Barr Virus Reactivation after Allogeneic Stem Cell Transplantation in Pre- and Post-Letermovir Era
Authors: Elisabetta Metafuni, Sabrina Giammarco, Maria Assunta Limongiello, Filippo Frioni, Rosaria Santangelo, Federica Sora, Eugenio Galli, Idanna Innocenti, Francesco Autore, Luca Laurenti, Andrea Bacigalupo, Giuseppe Leone, Patrizia Chiusolo, Simona Sica
Journal: Blood (2021)
Bradykinin Is a Proximal Event in Experimental Cerebral Malaria
Authors: Alessandro S Pinheiro, Douglas E Teixeira, Alona A. Merkulova, Keith R. McCrae, Philip J Rosenthal, Olena S Skomorovska-Prokvolit, Peng Zeng, Julio Scharfstein, D Midem, Sidney Ogalla, Arlene S Dent, Ana Acasia Pinheiro, James W Kazura, Alvin H. Schmaier
Journal: Blood (2021)
Hospitalization As a Risk Factor for Bleeding: The Medical Inpatients Thrombosis and Hemostasis (MITH) Study
Authors: Mansour Gergi, Katherine Wilkinson, Insu Koh, Jordan Munger, Hanny Al-Samkari, Nicholas L Smith, Nicholas S Roetker, Timothy B Plante, Allen B Repp, Mary Cushman, Chris E. Holmes, Neil A. Zakai
Journal: Blood (2021)
Once Weekly Oral Selinexor, Pomalidomide, and Dexamethasone in Relapsed Refractory Multiple Myeloma
Authors: Darrell J White, Christine I. Chen, Muhamed Baljevic, Sascha A. Tuchman, Nizar J. Bahlis, Gary J. Schiller, Brea Lipe, Rami Kotb, Heather J. Sutherland, William I. Bensinger, Sumit Madan, Michael Sebag, Suzanne Lentzsch, Natalie S. Callander, Noa Biran, Christopher P. Venner, Richard Leblanc, Jorge Monge, Evgeni Chubar, Tamar Tadmor, Noa Lavi, Merav Leiba, Andrew DeCastro, Dane R. Van Domelen, Chris Zhang, Moran Mishal, Ohad S. Bentur, Jatin J. Shah, Sharon Shacham, Michael G. Kauffman, Cristina J. Gasparetto
Journal: Blood (2021)
Abstract 9564: Zeb2 Shapes the Epigenetic Landscape of Atherosclerosis and Modulates the Risk of Myocardial Infarction
Authors: Paul Cheng, Robert Wirka, Quanyi Zhao, Juyong B Kim, Trieu Nguyen, Shoa L CLARKE, Ramendra K Kundu, Disha Sharma, Hyun-jung Kim, Huitong Shi, Themistocles L Assimes, Thomas Quertermous
Journal: Circulation (2021)

Smooth muscle cells (SMC) transition into a number of different phenotypes during atherosclerosis, including those that resemble fibroblasts and chondrocytes, and make up the majority of cells in atherosclerotic plaque. To better understand the epigenetic and transcriptional mechanisms that mediate these cell state changes, and how they relate to risk for coronary artery disease (CAD), we have investigated the causality and function of transcription factors (TFs) at genome wide associated loci. Employing in vitro CRISPR-Cas 9 genome and epigenome editing we show that complex genetic signals within a gene desert at 2q22.3 lie within novel smooth muscle long-distance enhancers for ZEB2 , a TF extensively studied in the context of epithelial mesenchymal transition (EMT) in development and cancer. Single-cell epigenetic and transcriptomic profiling demonstrated that Zeb2 regulates SMC phenotypic transition through chromatin remodeling that obviates accessibility and disrupts both Notch and TGFβ signaling, altering the epigenetic trajectory of SMC transitions. These changes resulted in an inability for transition SMC to turn off contractile programing and take on a fibroblast-like phenotype, and accelerated chondromyocyte differentiation, mirroring features of high-risk atherosclerotic plaques in human coronary arteries. Parallel epigenetic alterations are observed in human coronary artery smooth muscle cells, with ZEB binding motifs preferentially enriched for human genetic signals for coronary artery disease, affirming its role as a master epigenetic regulator of atherosclerosis pathology.
Abstract 9422: Assessment of Cardiotoxicity Following Thoracic Radiotherapy and Systemic Stem-Cell Derived Extracellular Vesicle Treatments
Authors: Ramin Badiyan, Pierre Montay-Gruel, Anjan S Batra, Charles Limoli
Journal: Circulation (2021)

Introduction: Radiotherapeutic management of certain cancers provides distinct benefits, but also results in variable degrees of cardiac exposure. Resultant radiation-induced heart disease (RIHD) typically manifests at protracted post-irradiation times and can involve a wide range of underlying pathologies including heart failure. Past work from our lab has identified an intervention involving systemic administration of human embryonic stem cell (hESC) derived extracellular vesicles (EV) shown to resolve radiation-induced lung disease (RILD). However, potential treatment-associated complications to the heart were not investigated. Hypothesis: In this study, we hypothesized that 1) radiation would cause a certain level of heart dysfunction, and 2) that stem cell-derived EV would not further confound RIHD. Methods: Separate cohorts of control (no radiation +/- EV) and treated (radiation +/- EV) mice were implemented in this study. For the treatment groups, mice were subjected to a single dose of image guided thoracic irradiation (14 Gy) and then systemically injected with hESC-derived EV at different time points. Echocardiography was performed in 4 cohorts (n=46); control arm (n=9), radiation alone arm (n=24), EV alone arm (no radiation) (n=5) and toxicity control arm involving 4 EV doses at weeks 0, 1, 2, 3) (n=8). The following parameters were compared between the 4 cohorts: E/A ratio, ejection fraction (EF), shortening fraction (SF), left ventricular mass (LV mass), end diastolic volume (EDV). Results: Radiation caused statistically significant lower E/A ratios compared with mice that did not receive radiation, with non-significant changes in other key indicators of cardiac function. Importantly, EV treatments had no effect on E/A ratio or any other indices of cardiac function among the different cohorts. Conclusions: Irradiated mice had lower E/A ratios but EF was unchanged, suggesting that thoracic exposures compromised diastolic function without impacting EF. Diastolic dysfunction was most likely linked to increased radiation-induced fibrosis and myocardium stiffness. Importantly, EV treatments were not observed to adversely impact cardiac function, pointing to the safety of this potential intervention for RILD.
Conditioning Intensity and Probability of Live Birth after Blood or Marrow Transplantation (BMT) - a Report from the BMT Survivor Study (BMTSS)
Authors: Nora Balas, Lindsey Hageman, Jessica Wu, Liton F. Francisco, Elizabeth Schlichting, Alysia Bosworth, Hok Sreng Te, Lennie Wong, Wendy Landier, Donna Salzman, Daniel J. Weisdorf, Stephen J Forman, Mukta Arora, Saro H. Armenian, Smita Bhatia
Journal: Blood (2021)
Prognostic Relevance of Tumor-Infiltrating T-Lymphocytes on Total Metabolic Tumor Volume-Based Risk Stratification of Patients with Diffuse Large B-Cell Lymphoma
Authors: Daisuke Ikeda, Kentaro Narita, Ami Fukumoto, Ayumi Kuzume, Yuya Kamura, Rikako Tabata, Toshiki Terao, Takafumi Tsushima, Daisuke Miura, Masami Takeuchi, Youichi Machida, Kosei Matsue
Journal: Blood (2021)
The Complex History of Genome Duplication and Hybridization in North American Gray Treefrogs
Authors: William W Booker, H Carl Gerhardt, Alan R Lemmon, Margaret B Ptacek, Alyssa T B Hassinger, Johannes Schul, Emily Moriarty Lemmon
Journal: Molecular Biology and Evolution (2021)

Polyploid speciation has played an important role in evolutionary history across the tree of life, yet there remain large gaps in our understanding of how polyploid species form and persist. Although systematic studies have been conducted in numerous polyploid complexes, recent advances in sequencing technology have demonstrated that conclusions from data-limited studies may be spurious and misleading. The North American gray treefrog complex, consisting of the diploid Hyla chrysoscelis and the tetraploid H. versicolor, has long been used as a model system in a variety of biological fields, yet all taxonomic studies to date were conducted with only a few loci from nuclear and mitochondrial genomes. Here, we utilized anchored hybrid enrichment and high-throughput sequencing to capture hundreds of loci along with whole mitochondrial genomes to investigate the evolutionary history of this complex. We used several phylogenetic and population genetic methods, including coalescent simulations and testing of polyploid speciation models with approximate Bayesian computation, to determine that H. versicolor was most likely formed via autopolyploidization from a now extinct lineage of H. chrysoscelis. We also uncovered evidence of significant hybridization between diploids and tetraploids where they co-occur, and show that historical hybridization between these groups led to the re-formation of distinct polyploid lineages following the initial whole-genome duplication event. Our study indicates that a wide variety of methods and explicit model testing of polyploid histories can greatly facilitate efforts to uncover the evolutionary history of polyploid complexes.
Authenticity—An Uphill Battle for a Black Woman in Cardiology
Authors: Zainab Mahmoud
Journal: JAMA Cardiology (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
P12.06 Computational Omics Biology Model (CBM) Identifies PD-L1 Immunotherapy Response Criteria Based on Genomic Signature of NSCLC
Authors: M. Castro, A.K. Ganti, H. Grover, A. Kumar, S. Mohapatra, K. Basu, D. Sahu, A. Tyagi, P. Nair, S. Prasad, P. Kumari, N. Mundkur, S. Patel, M. Sauban, L. Behura, S. Kulkarni, M. Patil, Y. Narvekar, A. Ghosh, Y. Ullal, A.R. Amara, S. Kapoor, V. Velcheti
Journal: Journal of Thoracic Oncology (2021)
Transcriptomic Features of Immune Exhaustion and Senescence Predict Outcomes and Define Checkpoint Blockade-Unresponsive Microenvironments in Acute Myeloid Leukemia
Authors: Sergio Rutella, Jayakumar Vadakekolathu, Francesco Mazziotta, Stephen Reeder, Tung On Yau, Rupkatha Mukhopadhyay, Heidi Altmann, Michael Kramer, Hanna A. Knaus, Joshua F. Zeidner, Vedran Radojcic, Andrea Arruda, Mark D. Minden, Sarah K Tasian, Martin Bornhäuser, Ivana Gojo, Leo Luznik
Journal: Blood (2021)
Implantable Insulin Pump vs Multiple-Dose Insulin for Non—Insulin-Dependent Diabetes Mellitus
Authors: C D Saudek, W C Duckworth, A Giobbie-Hurder, W G Henderson, R R Henry, D E Kelley, S V Edelman, F J Zieve, R A Adler, J W Anderson, R J Anderson, B P Hamilton, T W Donner, M S Kirkman, N A Morgan
Journal: JAMA (1996)

To determine whether implantable insulin pump (IIP) therapy and multiple daily insulin (MDI) injections could equally attain improved blood glucose control, and to compare the 2 treatments with respect to reducing daily blood glucose fluctuations, reducing serious hypoglycemic insulin reactions, and improving patients' quality of life.Randomized clinical trial.Seven Veterans Affairs medical centers.One hundred twenty-one male type II diabetic patients between the ages of 40 and 69 years, receiving at least 1 injection of insulin per day and having hemoglobin A1c (HbA1c) levels of 8% or above.Intensive therapy (IIP or MDI) for 1 year.Hemoglobin A1c and blood glucose levels.Blood glucose levels declined to 7.96+/-1.08 mmol/L (143.4+/-19.5 mg/dL) and 8.30+/-1.52 mmol/L (149.6+/-27.4 mg/dL) (mean +/- SD) for IIP and MDI, respectively (P=.57). Hemoglobin A1c levels improved in both groups (time effect P<.001), to means of 7.54%+/-0.83% (MDI) vs 7.34%+/-0.79% (IIP). IIP reduced blood glucose fluctuations compared with MDI (P<.001), and reduced the incidence of mild clinical hypoglycemia by 68% (P<.001); IIP also eliminated the weight gain associated with MDI therapy and yielded better overall quality-of-life (P=.03) and impact-of-disease subscale scores (P=.05). Adverse events included 25% of subjects with episodes of insulin underdelivery due to microprecipitates of insulin within the pump.Intensive insulin therapy with IIP and MDI is effective in controlling non-insulin-dependent diabetes mellitus. IIP has significant advantages in reducing glycemic variability, clinical hypoglycemia, and weight gain, while improving aspects of quality of life.