tbuckley/cabot-search huggingface dataset:
Fatty acid synthesis is required for breast cancer brain metastasis
Authors: Gino B. Ferraro, Ahmed Ali, Alba Luengo, David P. Kodack, Amy Deik, Keene L. Abbott, Divya Bezwada, Landry Blanc, Brendan Prideaux, Xin Jin, Jessica M. Posada, Jiang Chen, Christopher R. Chin, Zohreh Amoozgar, Raphael Ferreira, Ivy X. Chen, Kamila Naxerova, Christopher Ng, Anna M. Westermark, Mark Duquette, Sylvie Roberge, Neal I. Lindeman, Costas A. Lyssiotis, Jens Nielsen, David E. Housman, Dan G. Duda, Elena Brachtel, Todd R. Golub, Lewis C. Cantley, John M. Asara, Shawn M. Davidson, Dai Fukumura, Véronique A. Dartois, Clary B. Clish, Rakesh K. Jain, Matthew G. Vander Heiden
Journal: Nature Cancer (2021)
The effect of diltiazem on coronary flow reserve in humans.
Authors: J DRossen, ISimonetti, M LMarcus, PBraun, M DWinniford
Journal: Circulation (1989)

Calcium channel antagonists have been shown to blunt maximal coronary flow after brief coronary occlusion and during pharmacologic coronary dilation in animals. This property, if present in humans, would result in a reduction in coronary flow reserve in the absence of intrinsic abnormalities of the coronary circulation. A reduction of maximal vasodilator capacity by calcium channel antagonists could also constitute an important anti-ischemic mechanism of action of these agents. To evaluate the effect of calcium channel antagonists on coronary flow reserve in awake humans, we measured coronary flow reserve using the coronary Doppler catheter and intracoronary papaverine at baseline and after diltiazem administered by intravenous (125 or 250 micrograms/kg bolus, 5 micrograms/kg/min infusion, n = 8) or intracoronary (150-600 micrograms bolus, n = 10) routes. Intravenous diltiazem reduced heart rate from 77 +/- 18 to 72 +/- 17 beats/min (mean +/- SD, p less than 0.005) and reduced mean arterial pressure from ...
Demonstration of a widely distributed atrial pacemaker complex in the human heart.
Authors: J PBoineau, T ECanavan, R BSchuessler, M ECain, P BCorr, J LCox
Journal: Circulation (1988)

Atrial depolarization was analyzed in 14 patients with the Wolff-Parkinson-White syndrome undergoing surgery to ablate accessory atrioventricular pathways associated with tachyarrhythmias. Bipolar potentials were recorded simultaneously from 156 atrial epicardial electrodes arranged in three templates to fit the anterior and posterior aspects of both atria. Spontaneous or sinus rhythms were recorded, as were atrial escape rhythms after overdrive pacing at rates of 150 and 200 beats/min. Atrial activation maps revealed different patterns of impulse initiation varying from typical unifocal sinus node impulse origin, unifocal extranodal impulse origin, and multicentric impulse origin from two to four widely distributed atrial pacemaker sites. In subjects demonstrating only unifocal impulse origin during control or sinus rhythm, other widely divergent pacemaker sites were recorded in other maps during subsequent rhythms. In addition to sites located at the upper superior vena cava-right atrium junction, pacem...
Examination of the estrogenicity of 2,4,6,2',6'-pentachlorobiphenyl (PCB104), its hydroxylated metabolite 2,4,6,2',6'-pentachloro-4-biphenylol (HO-PCB104), and a further chlorinated derivative, 2,4,6,2',4',6'-hexachlorobiphenyl (PCB155)
Authors: Fielden
Journal: Environmental Health Perspectives (1997)
Relative location of alpha- and beta-adrenoceptors to sites of release of sympathetic transmitter in the rabbit facial vein.
Authors: R JWinquist, J ABevan
Journal: Circulation Research (1981)

We studied alpha- and beta-adrenoceptor-mediated responses of rabbit facial vein rings to adrenergic stimulation to determine the location of the two types of receptors in relation to the sympathetic nerve terminals. Transmural electrical nerve stimulation (TNS) at low frequency elicited large beta-receptor-mediated relaxation responses in rings pretreated with phentolamine (6 x 10(-7)M). These responses were significantly greater than the corresponding alpha-receptor-mediated contractions in rings pretreated with propranolol (10(-6)M). Blockade of neuronal uptake with desmethylimipramine (DMI, 10(-7)M) increased significantly the neurogenic relaxation but had little effect on neurogenic contractility. DMI pretreatment caused a shift to the left (x 5.6) in the relaxant dose-response curve to exogenous l-norepinephrine (NE). The NE contractile dose-response curve was also shifted to the left after DMI pretreatment but by a significantly smaller amount (x 3.1). Neurogenic activation of beta-receptors evoked...
Effect of loading conditions, contractile state, and heart rate on early diastolic left ventricular filling in conscious dogs.
Authors: C PCheng, G LFreeman, W PSantamore, M SConstantinescu, W CLittle
Journal: Circulation Research (1990)

We investigated left ventricular (LV) early diastolic filling in 10 normal conscious dogs that had been previously instrumented to measure LV and left atrial (LA) pressures and three orthogonal LV internal dimensions. LV volume was calculated as a general ellipsoid. The pressure within a passive structure increases as it is filled. If myocardial relaxation is rapid enough to substantially aid LV diastolic filling, it may overcome this effect and cause LV pressure to fall despite an increase in volume. Thus, we defined the amount of LV filling that occurred while LV pressure was falling as relaxation filling, which is a measure of the importance of LV relaxation during early diastolic filling. The time constant of relaxation (T) was derived from the exponential fall of LV pressure during isovolumic relaxation. While LV pressure was falling early in diastole (the relaxation filling period), all three LV diameters increased. Autonomic blockade with hexamethonium (5 mg/kg) and atropine (0.1 mg/kg) reduced rel...
Assessment of the human splanchnic venous volume-pressure relation using radionuclide plethysmography. Effect of nitroglycerin.
Authors: D EManyari, ZWang, JCohen, J VTyberg
Journal: Circulation (1993)

BACKGROUNDNo method exists to assess human splanchnic venous function, the most important region in terms of vascular capacity.METHODS AND RESULTSWe studied 25 stable patients without heart failure or hypertension to develop a method to assess the splanchnic venous volume-pressure (V-P) relation and to determine the effect of nitroglycerin (GTN). We used blood pool scintigraphy to assess changes in regional splanchnic vascular volume (SVV) and low levels of continuous positive airway pressure (CPAP) to passively alter venous pressure and thus, SVV. We postulated that the relation between SVV and the CPAP used would reflect the capacitance of the splanchnic venous bed and that changes in the position of this relation would provide a relative measurement of any change in capacitance. In 12 patients (group 1), the splanchnic vascular V-P curves were recorded before and 2, 9, and 20 minutes after 0.6 mg sublingual GTN; in eight patients (group 2), recordings were made at similar times before and after subling...
Association of Sociodemographic Factors and Blood Group Type With Risk of COVID-19 in a US Population
Authors: Jeffrey L. Anderson, Heidi T. May, Stacey Knight, Tami L. Bair, Joseph B. Muhlestein, Kirk U. Knowlton, Benjamin D. Horne
Journal: JAMA Network Open (2021)

suggested that blood group A was associated with increased susceptibility and blood group O was associated with reduced susceptibility to SARS-CoV-2 infection.These reports motivated widespread interest in examining ABO blood groups as potential COVID-19 risk factors.Subsequent studies from Italy and Spain 2 reported that blood group A was associated with an increased risk of severe COVID-19 and blood group O was associated with a reduced risk.In contrast, a large Danish study 3 implicated disease susceptibility but not severity.However, observations from Boston, Massachussets, 4 and New York, New York, 5 did not confirm any specific associations between ABO blood group and disease.The controversy raised by these contrasting reports led to this casecontrol study. MethodsOur objective in this case-control study was to independently test whether blood type is associated with SARS-CoV-2 susceptibility and COVID-19 severity.The study was approved by the Intermountain Medical Center institutional review board with a waiver of consent because the study represented no more than minimal privacy risk to individuals.This study is reported following the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline.Intermountain Healthcare, a nonprofit, integrated health care system of 24 hospitals and 215 clinics in Utah, Idaho, and Nevada, generated a SARS-CoV-2 and COVID-19-specific electronic health records database.We searched this database for individuals who were tested for SARS-CoV-2 between March 3 and November 2, 2020, and had a recorded blood type.For individuals who underwent multiple tests, the first test with a positive result was chosen, otherwise the first test with a negative result was used.We compared positive vs negative test results, hospitalized vs nonhospitalized patients, and intensive care unit (ICU) vs non-ICU patients.Infectivity was determined by SARS-CoV-2-specific polymerase chain reaction testing of nasal swabs or saliva samples.Analysis of variance assessed associations across ABO groups.Odds ratios (ORs) between ABO groups were assessed by logistic regression adjusted for age, sex, and Rh factor.P values were 2-sided, and statistical significance was set at P < .167for each of the 3 primary comparisons.Statistical significance was set at P = .006for assessment of ORs because each set underwent 9 comparisons.Data were analyzed from November 20, 2020, to February 26, 2021. ResultsA total of 107 796 individuals (mean [SD] age, 42.0 [17.8] years; 82 875 [76.9%] women) who had been tested for SARS-CoV-2 infection were included in the study.Further demographic characteristics of the studied population and ABO blood group associations are shown in Table 1.
Modeling and Understanding the Biology of Transplant-Mediated HIV Cure in a Non-Human Primate Model
Authors: Lucrezia Colonna, John B Schell, Christopher Peterson, Judith M Carlson, Melanie Brown, Victor Tkachev, Agne Taraseviciute, Scott N. Furlan, Hengqi Zheng, Daniel J Hunt, Alison Yu, Jennifer Lane, Cassie Moats, Keith Vogel, Charlotte E Hotchkiss, Robert Murnane, Audrey Baldessari, Christopher English, Michelle Hoffman, Katie Zeleski, Joe Olvera, Cliff A Astley, Solomon Wangari, Brian Agricola, Joel Ahrens, Naoto Iwayama, Patricia S Polacino, Heather M Mack, Laurence Stensland, Meei-Li Huang, Shiu-Lok Hu, Hans-Peter Kiem, Leslie Kean
Journal: Blood (2017)
Endoscopic Ultrasound Guided Drainage Of Patients With Infected Walled Off Necrosis: Which Stent To Choose?
Authors: G Muktesh, J Samanta, J Dhar, R Agarwala, BL Bellum, P Gupta, TD Yadav, V Gupta, SK Sinha, R Kochhar
Journal: Endoscopy (2021)

Aims We aimed to compare clinical outcomes of endoscopic ultrasound (EUS) guided drainage procedure using biflanged metal stents (BFMS) or double pigtail plastic stents (DPPS) amongst patients with pancreatic fluid collections and subgroup with infected walled off necrosis (WON).
Noninvasive determination of coronary artery bypass graft patency by cine magnetic resonance imaging.
Authors: G PAurigemma, NReichek, LAxel, MSchiebler, CHarris, H YKressel
Journal: Circulation (1989)

Cine magnetic resonance imaging (MRI) is a gradient-recalled, retrospectively gated, fast-scan technique that depicts laminar flowing blood as bright signal and has been proposed as a useful method for determination of coronary artery bypass graft (CABG) patency. Therefore, we performed a blinded prospective study to assess the value of cine MRI determination of CABG patency in 20 patients with 45 CABG proximal anastomoses who were undergoing repeat angiography. Ten normal subjects served as controls to define normal intrathoracic vascular patterns. There were 21 left anterior descending (LAD) grafts, of which four were left internal mammary (LIMA), 12 left circumflex (Cx), and 12 right coronary (RCA) grafts. After localizing spin-echo coronal images were obtained, multiple axial multislice interleaved cine MRI acquisitions, each consisting of two to four 5-10-mm-thick slices at eight to 24 frames per cardiac cycle, were obtained from the superior main pulmonary artery to the inferior left ventricle. Each...
Hypoxia stimulates prostacyclin synthesis in newborn pulmonary artery endothelium by increasing cyclooxygenase-1 protein.
Authors: A JNorth, T SBrannon, L BWells, W BCampbell, P WShaul
Journal: Circulation Research (1994)

In newborn lambs, pulmonary prostacyclin (PGI2) production increases acutely in response to low oxygen. We tested the hypothesis that decreased oxygenation directly stimulates PGI2 synthesis in arterial segments and cultured endothelial cells from newborn lamb intrapulmonary arteries. In segments studied at PO2 of 680 mm Hg, the synthesis of PGI2 exceeded prostaglandin E2 (PGE2) by 73%. Endothelium removal lowered PGI2 by 77% and PGE2 by 66%. At low oxygen tension (PO2, 40 mm Hg), PGI2 and PGE2 synthesis rose by 96% and 102%, respectively. Similarly, in endothelial cells studied at PO2 of 680 mm Hg, the synthesis of PGI2 exceeded PGE2 by 50%, and at low oxygen tension both PGI2 and PGE2 increased (89% and 64%, respectively). Endothelial cell PGI2 synthesis maximally stimulated by bradykinin, A23187, or arachidonic acid was also increased at low PO2 by 50%, 66%, and 48%, respectively. PGE2 synthesis was similarly altered, increasing by 33%, 37%, and 41%, respectively. In contrast, lowering oxygen had minim...
Dietary therapy for different forms of hyperlipoproteinemia.
Authors: S MGrundy
Journal: Circulation (1987)

Diet is the first line of therapy for hypercholesterolemia. The major dietary factors raising the plasma cholesterol are saturated fatty acids, cholesterol, and excess total calories. For almost all forms of hyperlipidemia, the first principle of dietary therapy is to reduce saturated fatty acids, decrease cholesterol, and curtail excess calories. In patients with severe hypercholesterolemia, marked restrictions of diet may be necessary. For these patients, drugs may be required to control cholesterol levels. However, the majority of patients with elevated plasma cholesterol can achieve a satisfactory reduction of cholesterol levels by diet, and drugs will not be necessary. Dietary therapy alone is adequate for most patients with familial forms of hypertriglyceridemia, but for a few patients drugs are required.
Hepatology. A Textbook of Liver Disease
Journal: Annals of Internal Medicine (1990)

Section I: Anatomy, Physiology and Biochemistry of Liver Function. Section II: Systemic Effects of Liver Disease. Section III: Evaluation of Liver Function. Section IV: Etiologies, Clinical Characteristics, Diagnosis and Management of Specific Liver Diseases. A: Toxic Injury. B: Acute Liver Disease Due to Infectious Agents. C: Chronic Liver Disease. D: Tumors of the Liver. E: Liver Disease Primarily of Children. F: Special Topics. G: Biliary Tract Disease.
The conduction system in double outlet right ventricle with subpulmonic ventricular septal defect and related hearts (the Taussig-Bing group).
Authors: SBharati, MLev
Journal: Circulation (1976)

The Taussig-Bind group of hearts is that group in which the aorta emerges completely from the right ventricle, unrelated to the position of the ventricular septal defect (VSD), while the pulmonary trunk emerges at varying degrees from the right ventricle related to the location of the VSD. Several types of surgical procedures involve the VSD in these hearts. The conduction systems in six of these hearts were therefore studied. The atrioventricular (A-V) bundle lies in the inferior (posterior) wall of the defect on the left side beneath the summit of the ventricular septum. In some cases, the bundle may be proximal to the defect, thus lying intramuscularly, and only the right and left bundle branches are related to the defect. The pattern od development of the atrioventricular (A-V) node, bundle and bundle branches is related primarily to the development of the endocardial cushions and posterior ventricular septum, and not to that of the absorption of the bulbus.
A Woman With Fetal Loss
Authors: Mandy Sander-Prather, Martin De Ruyter
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Characteristics of left ventricular receptors with nonmedullated vagal afferents in cats.
Authors: P NThorén
Journal: Circulation Research (1977)

Activity from left ventricular receptors with non-medullated afferents was recorded in the right cervical vagus in anesthetized, thoracotomized cats. Probing of the open heart demonstrated that the receptors were distributed throughout the free wall and the interventricular septum. Fibers from posterior receptors pass along the posterior descending coronary artery and the lateral surface of the right atrium to join the right main cardiac nerve; those from the anteriolateral region pass behind the aorta and the pulmonary trunk. The control receptor discharge was 1.4 (range, 0-6) impulses/sec at a mean left ventricular end-diastolic pressure (LVEDP) of 4.5 (range, 2-10) mm Hg. It was observed that receptor discharge increased with progressive increase in LVEDP produced either by transfusion or by aortic occlusion. At a mean LVEDP of 8 mm Hg, the mean discharge rate was 3.2 impulses/sec, and at 16 mm Hg it was 7.0 impulses/sec. It was also found that propranolol reduced and isoproterenol increased the discha...
Mechanisms of improved ischemic regional dysfunction by bradycardia. Studies on UL-FS 49 in swine.
Authors: CIndolfi, B DGuth, TMiura, SMiyazaki, RSchulz, JRoss
Journal: Circulation (1989)

In anesthetized swine, the left anterior descending coronary artery was cannulated and perfused at constant blood flow levels during two grades of ischemia. In one group (n = 10), moderate ischemia reduced percent systolic wall thickening (by sonomicrometry) from 25 +/- 7% to 6 +/- 2%, whereas in the other group (n = 7), severe ischemia reduced percent wall thickening from 24 +/- 6% to -0.5 +/- 4%. Heart rate was paced in both groups at 91 beats/min. After reperfusion and complete return to control conditions, administration of the bradycardic agent UL-FS 49 (0.37 mg/kg i.v.) decreased the heart rate to 55 +/- 5 beats/min. During subsequent ischemia at the same coronary inflow as before bradycardia, percent wall thickening in the ischemic zone during moderate ischemia was increased from 6 +/- 2% to 25 +/- 6% (p less than 0.01) (not significantly different from control without ischemia), and during severe ischemia, percent wall thickening increased from -0.5 +/- 4% to 13 +/- 7% (p less than 0.01). During m...
Assessment of left ventricular relaxation by Doppler echocardiography. Comparison of isovolumic relaxation time and transmitral flow velocities with time constant of isovolumic relaxation.
Authors: YMyreng, O ASmiseth
Journal: Circulation (1990)

Isovolumic relaxation time (IVRT) and events of early transmitral flow measured by Doppler echocardiography were validated against the time constant of left ventricular relaxation (tau) in open-chest dogs. During increased inotropy (by isoproterenol infusion) at constant preload, enhancement of relaxation was indicated by a decrease in tau from 48 +/- 12 (mean +/- SD) to 33 +/- 5 msec (p = 0.04) with a concomitant decrease in IVRT from 74 +/- 18 to 38 +/- 8 msec (p = 0.03). During decreased inotropy (by propranolol infusion) at constant preload, slowing of relaxation was indicated by an increase in tau from 40 +/- 8 to 51 +/- 13 msec (p = 0.02) with a concomitant increase in IVRT from 71 +/- 15 to 83 +/- 21 msec (p less than 0.05). A significant correlation between changes in tau and changes in IVRT was found (r = 0.66, p less than 0.001). In contrast, when left ventricular end-diastolic pressure was increased from 7 +/- 2 to 24 +/- 4 mm Hg at constant inotropy, tau increased from 47 +/- 14 to 64 +/- 25 m...
Prehospital Tranexamic Acid Administration in Injured Patients
Authors: Shaoyun Zhang, Cong Xiao, Zhixiang Gao
Journal: JAMA Surgery (2021)

To the Editor As Guyette and colleagues1 report, prehospital administration of tranexamic acid (TXA) in injured patients at risk for hemorrhage is safe and associated with lower 30-day mortality in specific subgroups of patients. However, some results require further explanation.
Work Of The Endoscopic Department Of A Multi-Specialty Hospital In The Context Of A Pandemic Covid-19
Authors: M Antipova, D Rusanov, A Ogloblin, I Zarubova, A Taronishvili, M Korolev
Journal: Endoscopy (2021)

Aims To analyze the results of the endoscopic department of a large multi-specialty city hospital in the context of the COVID-19 pandemic and assess the prospects for further effective functioning of the endoscopic service.
Subpopulations of rat vascular smooth muscle cells as discriminated by calcium release mechanisms from internal stores.
Authors: W SShin, TToyo-oka, MMasuo, YOkai, HFujita, TSugimoto
Journal: Circulation Research (1991)

Transsarcolemmal influx and release from the sarcoplasmic reticulum (SR) through specific Ca2+ channels are the two main pathways to elevate cytosolic Ca2+ (Ca2+i) in vascular smooth muscle cells (VSMCs). To elucidate intercellular distribution and function of the Ca2+ channel in SR in cultured VSMCs, we observed Ca2+i transients by digital two-dimensional imaging with a fluorescent Ca2+ indicator, fura-2, and found an alternative response to either caffeine or angiotensin II under the condition that selectively enabled Ca2+ release from SR. Caffeine (20 mM) increased the Ca2+i by 292 +/- 36% (mean +/- SEM) over the basal level in one third of the VSMC population (n = 19), while the remaining cells in the same observation field showed no or very weak response (110 +/- 4%). In contrast, after the treatment with caffeine plus ryanodine (30 microM), which inactivates the caffeine-sensitive channel, and with 1 mM Ca2+ chelator (EGTA) instead of Ca2+ in the incubation medium to block the CA2+ entry from outsid...
Phase I study of pharmacologically based dosing of carboplatin with filgrastim support in women with epithelial ovarian cancer
Authors: Lind, GhazalAswad, Gumbrell, Fishwick, Craigs, Millward, Bailey, DoreGreen, Chapman, Simmons, Proctor, Oakey, Robson, Middleton, McCann, Sinha, Calvert
Journal: Journal of Clinical Oncology (1996)