tbuckley/cabot-search huggingface dataset:
Correction: Recommended Childhood Immunization Schedule—United States, 2000
Journal: JAMA (2000)

indirectly related death was defined as one that did not result from physical contact with a storm product, but would not have happened if the storm had not occurred.Thirty-one deaths were considered directly or indirectly related to the storm (29 directly and two indirectly).Deaths occurred in 24 separate incidents in nine Texas counties.Thirty of the victims were Texas residents, and one was a Louisiana resident visiting Texas.Decedents ranged in age from 2 months to 83 years (median: 38 years); 20 decedents were males.Cause of death for the 31 decedents included drowning (24 [77%]), cardiac origin (three [10%]), multiple trauma (three [10%]), and hypothermia (one [3%]).Of the 29 deaths directly related to the storm, 24 were caused by drowning.Three persons died of multiple trauma, one of hypothermia after submersion in water, and one of cardiac arrhythmia induced after he became trapped in a water crossing (i.e., a road traversing a low-lying area that is subject to flooding).Two died indirectly from the storm: one man died while awaiting rescue by emergency personnel who were unable to reach his residence because of flooding, and a second man died in his truck in a water crossing on his property.Twenty-two of the 29 cases with known circumstances occurred because a vehicle was driven into high water.These deaths occurred in 16 separate incidents.Four of these incidents resulted in multiple deaths.Of the 16 water-crossing incidents, 11 (69%) occurred at locations known to reporting authorities to have a history of flooding.Of the 16 water-crossing incidents, 10 (63%) involved trucks and/or sport-utility vehicles.
Radiology, Detroit
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of the degree of left ventricular hypertrophy on hemodynamic adaptation to exercise in hypertrophic cardiomiopathy Quirino Ciampi, Sandro Betocchi, Anna Violante, Fiore Manganelli, Maria A. Losi, Giulia Sica, Carlo G. Tocchetti, Raffaella Lombardi, Teresa Pellegrino, Esther Campopiano, Mariano Aversa, Alberto Cuocolo, Massimo Chiariello. Federico II University school of Medicine, Naples, Italy
Journal: Journal of the American College of Cardiology (2001)
Infectious disease surveillance update
Authors: Pam Das
Journal: The Lancet Infectious Diseases (2003)

A cholera epidemic is just one part of the mounting health crisis that civilians are facing in war-torn Liberia. More than 97 000 displaced people live in temporary camps in and around the Liberian capital of Monrovia, where access to clean water, basic sanitary facilities, food, and health care is rudimentary at best. Several camps have no health services whatsoever to offer.
Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection
Authors: Chansavath Phetsouphanh, David R. Darley, Daniel B. Wilson, Annett Howe, C. Mee Ling Munier, Sheila K. Patel, Jennifer A. Juno, Louise M. Burrell, Stephen J. Kent, Gregory J. Dore, Anthony D. Kelleher, Gail V. Matthews
Journal: Nature Immunology (2022)
Echocardiographic probability of pulmonary hypertension: a validation study
Authors: Michele D'Alto, Marco Di Maio, Emanuele Romeo, Paola Argiento, Ettore Blasi, Alessandro Di Vilio, Gaetano Rea, Antonello D'Andrea, Paolo Golino, Robert Naeije
Journal: European Respiratory Journal (2022)

According to current guidelines, the diagnosis of pulmonary hypertension (PH) relies on echocardiographic probability followed by right heart catheterisation (RHC). How echocardiography predicts PH recently redefined by mean pulmonary arterial pressure (mPAP) >20 mmHg instead of ≥25 mmHg and pulmonary vascular disease defined by pulmonary vascular resistance (PVR) ≥3 or >2 WU has not been established.A total of 278 patients referred for PH underwent comprehensive echocardiography followed by RHC. 15 patients (5.4%) were excluded because of insufficient quality echocardiography.With PH defined by mPAP >20 mmHg, 23 patients had no PH, 146 had pre-capillary PH and 94 had post-capillary PH. At univariate analysis, maximum tricuspid regurgitation velocity (TRV) 2.9-3.4 m·s-1, left ventricle (LV) eccentricity index >1.1, right ventricle outflow tract acceleration time (RVOT-AT) <105 ms or notching, RV/LV basal diameter >1 and pulmonary artery diameter predicted PH, whereas inferior vena cava diameter and right atrial area did not. At multivariable analysis, only TRV ≥2.9 m·s-1 independently predicted PH. Additional independent prediction of PVR ≥3 WU was offered by LV eccentricity index >1.1, and RVOT-AT <105 ms and/or notching, but with no improvement of optimal combination of specificity and sensitivity or positive prediction.Echocardiography as recommended in current guidelines can be used to assess the probability of redefined PH in a referral centre. However, the added value of indirect signs is modest and sufficient quality echocardiographic signals may not be recovered in some patients.
Endothelin-A receptor antagonism prevents progression of hypertensive myocardial remodeling and impairment of myocardial function more effectively than ACE inhibition in stroke-prone spontaneously hypertensive rats Alexander Reinecke, Marc Dorenkamp, Quingui Xia, Harro Bitterling, Sussane Penz, Christian Storz, Netja Weisner, Oliver Chung, R�diger W.R. Simon and Thomas Unger. Clinic of Cardiology, University of Kiel, Kiel, Germany, Institute of Pharmacology, University of Kiel, Kiel, Germany
Journal: Journal of the American College of Cardiology (2001)
From the Surgeon General, US Public Health Service
Authors: A. C. Novello
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Utilization Rates of SGLT2 Inhibitors and GLP-1 Receptor Agonists and Their Facility-Level Variation Among Patients With Atherosclerotic Cardiovascular Disease and Type 2 Diabetes: Insights From the Department of Veterans Affairs
Authors: Dhruv Mahtta, David J. Ramsey, Michelle T. Lee, Liang Chen, Mahmoud Al Rifai, Julia M. Akeroyd, Elizabeth M. Vaughan, Michael E. Matheny, Karla Rodrigues do Espirito Santo, Sankar D. Navaneethan, Carl J. Lavie, Yochai Birnbaum, Christie M. Ballantyne, Laura A. Petersen, Salim S. Virani
Journal: Diabetes Care (2022)

OBJECTIVE There is mounting evidence regarding the cardiovascular benefits of sodium–glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide 1 receptor agonists (GLP-1 RA) among patients with atherosclerotic cardiovascular disease (ASCVD) and type 2 diabetes mellitus (T2DM). There is paucity of data assessing real-world practice patterns for these drug classes. We aimed to assess utilization rates of these drug classes and facility-level variation in their use. RESEARCH DESIGN AND METHODS We used the nationwide Veterans Affairs (VA) health care system data set from 1 January 2020 to 31 December 2020 and included patients with established ASCVD and T2DM. Among these patients, we assessed the use of SGLT2i and GLP-1 RA and the facility-level variation in their use. Facility-level variation was computed using median rate ratios (MRR), a measure of likelihood that two random facilities differ in use of SGLT2i and GLP-1 RA in patients with ASCVD and T2DM. RESULTS Among 537,980 patients with ASCVD and T2DM across 130 VA facilities, 11.2% of patients received an SGLT2i while 8.0% of patients received a GLP-1 RA. Patients receiving these cardioprotective glucose-lowering drug classes were on average younger and had a higher proportion of non-Hispanic Whites. Overall, median (10th–90th percentile) facility-level rates were 14.92% (9.31–22.50) for SGLT2i and 10.88% (4.44–17.07) for GLP-1 RA. There was significant facility-level variation among SGLT2i use—MRRunadjusted: 1.41 (95% CI 1.35–1.47) and MRRadjusted: 1.55 (95% CI 1.46 –1.63). Similar facility-level variation was observed for use of GLP-1 RA—MRRunadjusted: 1.34 (95% CI 1.29–1.38) and MRRadjusted: 1.78 (95% CI 1.65–1.90). CONCLUSIONS Overall utilization rates of SGLT2i and GLP-1 RA among eligible patients are low, with significantly higher residual facility-level variation in the use of these drug classes. Our results suggest opportunities to optimize their use to prevent future adverse cardiovascular events among these patients.
Identification of Gut Bacteria such as Lactobacillus johnsonii that Disseminate to Systemic Tissues of Wild Type and MyD88–/– Mice
Authors: Sreeram Udayan, Panagiota Stamou, Fiona Crispie, Ana Hickey, Alexandria N. Floyd, Chyi-Song Hsieh, Paul D. Cotter, Orla O’Sullivan, Silvia Melgar, Paul W. O’Toole, Rodney D. Newberry, Valerio Rossini, Ken Nally
Journal: Gut Microbes (2022)

In healthy hosts the gut microbiota is restricted to gut tissues by several barriers some of which require MyD88-dependent innate immune sensor pathways. Nevertheless, some gut taxa have been reported to disseminate to systemic tissues. However, the extent to which this normally occurs during homeostasis in healthy organisms is still unknown. In this study, we recovered viable gut bacteria from systemic tissues of healthy wild type (WT) and MyD88−/− mice. Shotgun metagenomic-sequencing revealed a marked increase in the relative abundance of L. johnsonii in intestinal tissues of MyD88−/− mice compared to WT mice. Lactobacillus johnsonii was detected most frequently from multiple systemic tissues and at higher levels in MyD88−/− mice compared to WT mice. Viable L. johnsonii strains were recovered from different cell types sorted from intestinal and systemic tissues of WT and MyD88−/− mice. L. johnsonii could persist in dendritic cells and may represent murine immunomodulatory endosymbionts.
Hyperthyroidism
Authors: Irwin Klein
Journal: Annals of Internal Medicine (1995)

Letters1 March 1995HyperthyroidismIrwin Klein, David V. Becker, and Gerald S. LeveyIrwin KleinSearch for more papers by this author, David V. BeckerSearch for more papers by this author, and Gerald S. LeveySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-5-199503010-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Bohlmann described a case of thrombocytopenia in a pregnant woman with Graves disease who was treated with propylthiouracil. Although the association of Graves disease and thrombocytopenia is well known, it is not clear from the case that the decrease in the platelet count was related to the propylthiouracil therapy or, alternatively, the manifestation of coexistent autoimmune thrombocytopenia. If treatment with propylthiouracil was continued, it would be interesting to know if the patient was still receiving propylthiouracil when she responded to prednisone. Propylthiouracil-mediated agranulocytosis is presumably immunologically mediated. A report from Magner and Snyder [1] provides additional evidence ...References1. Magner JA, Snyder DK. Methimazole-induced agranulocytosis treated with recombinant human granulocyte colony-stimulating factor (G-CSF). Thyroid. 1994; 4:295-6. Google Scholar2. Klein I, Becker DV, Levey GS. Treatment of hyperthyroid disease. Ann Intern Med. 1994; 121:281-8. Google Scholar3. Nakazawa K, Sakurai K, Hamada N, Momotani N, Ito K. Management of atrial fibrillation in the post-thyrotoxic state. Am J Med. 1982; 306:1018-22. Google Scholar4. Presti CF, Hart RG. Thyrotoxicosis, atrial fibrillation, and embolism, revisited. Am Heart J. 1989; 117:976-7. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHigh power metal hydride bipolar battery 1 March 1995Volume 122, Issue 5Page: 393-394KeywordsAtrial fibrillationCardiovascular therapyHyperthyroidismPatientsPituitary tumorsPlateletsPregnancyRisk managementStem cellsSurgery ePublished: 15 August 2000 Issue Published: 1 March 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
US Medical School Finances
Authors: Paul Jolly
Journal: JAMA (1988)

The 28th annual review of medical school finances is intended to reflect, through financial analysis of revenues and expenditures, the secular trends in medical education in the United States. The 28-year interval may be viewed as two distinct periods, from academic year 1958-1959 to academic year 1978-1979 and from academic year 1979-1980 to academic year 1986-1987, the latest year for which data are available. The first period can be characterized by huge absolute and relative increases in all aspects of medical education. Some sense of growth in the enterprise over the 20-year interval from 1958-1959 to 1978-1979 may be gleaned from an examination of a few of its dimensions shown in Table 1. The number of schools increased, the number of candidates for professional and academic doctorates doubled and tripled, respectively, and the population of postdoctoral students mushroomed. The eight-year period from 1979-1980 to 1986-1987, on the other hand, exhibits
The Propaganda for Reform
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOCIETY NEWS.
Authors: James Moores Ball
Journal: JAMA (1894)

<h3>Mississippi Valley Medical Association.</h3> —The twentieth annual meeting of this well-known organization will be held, as previously announced, at Hot Springs, Ark., November 20, 21, 22 and 23, 1894. The general committee of arrangements held their final meeting on September 1, in the city of St. Louis, there being present, in addition to the committee, President Scott, of Cleveland, Vice-President Strauss of St. Louis and Secretary Woodburn, of Indianapolis. Dr. T. E. Holland, of Hot Springs, presided. All of the preliminary arrangements for the meeting of the Association were completed. Owing to the hearty coöperation of the railroads, the arrangements in this direction will surpass those of any previous meeting. On motion of Dr. I. N. Love, of St. Louis, a committee of five railroad officials was appointed to secure the desired reduction of rates. This committee consists of Messrs. Townsend, Crane, Snyder, Wishard and Ives. The interest and enthusiasm
Patient-centred approaches for the management of unpleasant symptoms in kidney disease
Authors: Kamyar Kalantar-Zadeh, Mark B. Lockwood, Connie M. Rhee, Ekamol Tantisattamo, Sharon Andreoli, Alessandro Balducci, Paul Laffin, Tess Harris, Richard Knight, Latha Kumaraswami, Vassilios Liakopoulos, Siu-Fai Lui, Sajay Kumar, Maggie Ng, Gamal Saadi, Ifeoma Ulasi, Allison Tong, Philip Kam-Tao Li
Journal: Nature Reviews Nephrology (2022)
Circulating nucleosomes for detection of colorectal cancer and high-risk advanced adenomas.
Authors: Li-Chun Chang, Marielle Herzog, Nathalie Hardat, Dorian Pamart, Han Mo Chiu
Journal: Journal of Clinical Oncology (2022)

169 Background: Detection and treatment of early colorectal cancer (CRC) or advanced adenomas (AA) is the key for superior outcomes and fecal immunochemical testing (FIT)-based screening has proven effective in reducing CRC death and the risk of advanced-stage CRC but the discrepancy in the effectiveness was observed between proximal and distal cancers. On the other hand, false-positive results of FIT with 60 % of negative colonoscopy is another concern, considering the burden to the screening participants and the healthcare providers. A blood-based test as an alternative or supplement to FIT has the potential to concurrently enhance the detection of high-risk neoplasms and identify individuals at risk who should then be referred to colonoscopy. We investigated the levels of circulating free nucleosomes containing different epigenetic modifications in patients referred for colonoscopy. Methods: 10mls whole blood was obtained from 520 asymptomatic patients prior to colonoscopy at National Taiwan University Hospital. Patients were classified into 5 groups based on their colonoscopy reports: (i) patient with CRC (n = 33), (ii) patients with AA (n = 123, including 18 with AA &gt; 2cm); (iii) patients with non-AA (n = 168); (iv) patients with non-neoplastic polyps (n = 30); (vi) healthy controls with no endoscopic lesion (n = 166). Plasma samples were analyzed for nucleosome levels using 7 different quantitative immunoassays (Nu.Q assays; Belgian Volition SRL, Belgium) targeting H3.1-nucleosomes or different histone modifications (H3K27Me3-, H3K36Me3-, H3K9Me3-, H3K14Ac-, H3K27Ac- or H3R8Cit-nucleosomes). All study subjects were asked to collect a stool sample at home within 48-hours before the colonoscopy. The fecal samples were assayed with the Eiken OC-SENSOR FIT kit (Eiken Chemical Co., Ltd., Tokyo, Japan) for all study subjects. Results: At a cut-off of 20µg/g feces, the FIT test showed a sensitivity of 92,9% at 17.5% specificity for CRC +AA vs. Controls. All the CRC patients and 83.3% of the high-risk AA (&gt; 2cm) patients were FIT positive. A combination of 2 Nu.Q biomarkers: H3K27Me3 and H3R8Cit with FIT in a logistic regression model showed improved sensitivity of 95% at 20.6% specificity allowing the detection of all CRC patients and 94.3% of AA patients including all the high-risk adenomas. The FIT test detected 46 out of 55 proximal adenomas whereas the combined model could detect 50 proximal adenomas including 3 proximal AA &gt; 2cm not being detected by FIT (p &lt; 0.05). The same combination would reduce unnecessary colonoscopies by 21.8% of the control and 23.3% of the non-neoplastic polyps subgroups compared to 17.5% and 6.7%, respectively with the FIT test alone. Conclusions: Our results indicate that H3K27Me3 and H3R8Cit-nucleosome levels in combination with FIT could improve the detection of proximal high-risk AA and could also provide a non-invasive method to reduce unnecessary colonoscopy.
Transactions of the Fifty-first Annual Meeting of the Ohio State Medical Society, held at Columbus, May 27, 28 and 29, 1896.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A CONSIDERATION OF THE GASTRIC TEST MEAL FROM EXPERIMENTAL DATA
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal