tbuckley/cabot-search huggingface dataset:
Quantitative Myocardial Cytokine Expression and Activation of the Apoptotic Pathway in Patients Who Require Left Ventricular Assist Devices
Authors: Emma J. Birks, Najma Latif, Virginia Owen, Christopher Bowles, Leanne E. Felkin, Anthony J. Mullen, Asghar Khaghani, Paul J.R. Barton, Julia M. Polak, John R. Pepper, Nicholas R. Banner, Magdi H. Yacoub
Journal: Circulation (2001)

Background Molecular mechanisms underlying the deterioration of patients undergoing LV assist device (LVAD) implantation remain poorly understood. We studied the cytokines tumor necrosis factor (TNF)-α and interleukin (IL)-1β and IL-6 and the terminal stage of the apoptotic pathway in patients with decompensating heart failure who required LVAD support and compared them with patients with less severe heart failure undergoing elective heart transplantation. Methods and Results Myocardial and serum samples from 23 patients undergoing LVAD implantation were compared with those from 36 patients undergoing elective heart transplantation. Myocardial TNF-α mRNA (1.71-fold; P &lt;0.05) and protein (3.43±0.19 versus 2.95±0.10 pg/mg protein; P &lt;0.05) were elevated in the LVAD patients. Immunocytochemistry demonstrated TNF expression in the myocytes. Serum TNF-α was also elevated (12.5±1.9 versus 4.0±0.4 pg/mL; P &lt;0.0001) in the LVAD patients. IL-6 mRNA (2.57-fold higher; P &lt;0.005) and protein (27.83±9.35 versus 4.26±1.24 pg/mg protein; P &lt;0.001) were higher in the LVAD candidates, as was serum IL-6 (79.3±23.6 versus 7.1±1.6 pg/mL; P &lt;0.0001). Interleukin-1β mRNA expression was 9.78-fold higher in the LVAD patients ( P &lt;0.001). iNOS mRNA expression was similar to that in advanced heart failure patients and was not further elevated in the LVAD patients. Levels of procaspase-9 (8.02±0.91 versus 6.16±0.43 oligodeoxynucleotide [OD] units; P &lt;0.01), cleaved caspase-9 (10.02±1.0 versus 7.34±0.40 OD units; P &lt;0.05), intact and spliced DFF-45 (4.58±0.75 versus 2.84±0.23 OD units; P &lt;0.05) were raised in LVAD patients, but caspase-3 and human nuclease CPAN were not. Conclusions Elevated TNF-α, IL-1β, and IL-6 and alterations in the apoptotic pathway were found in the myocardium and elevated TNF-α and IL-6 in serum of deteriorating patients who required LVAD support. These occurrences may have therapeutic implications and influence the timing of LVAD insertion.
Social Ties and Susceptibility to the Common Cold
Authors: Sheldon Cohen
Journal: JAMA (1997)

<h3>Objective.</h3> —To examine the hypothesis that diverse ties to friends, family, work, and community are associated with increased host resistance to infection. <h3>Design.</h3> —After reporting the extent of participation in 12 types of social ties (eg, spouse, parent, friend, workmate, member of social group), subjects were given nasal drops containing 1 of 2 rhinoviruses and monitored for the development of a common cold. <h3>Setting.</h3> —Quarantine. <h3>Participants.</h3> —A total of 276 healthy volunteers, aged 18 to 55 years, neither seropositive for human immunodeficiency virus nor pregnant. <h3>Outcome Measures.</h3> —Colds (illness in the presence of a verified infection), mucus production, mucociliary clearance function, and amount of viral replication. <h3>Results.</h3> —In response to both viruses, those with more types of social ties were less susceptible to common colds, produced less mucus, were more effective in ciliary clearance of their nasal passages, and shed less virus. These relationships were unaltered by statistical controls for prechallenge virus-specific antibody, virus type, age, sex, season, body mass index, education, and race. Susceptibility to colds decreased in a dose-response manner with increased diversity of the social network. There was an adjusted relative risk of 4.2 comparing persons with fewest (1 to 3) to those with most (6 or more) types of social ties. Although smoking, poor sleep quality, alcohol abstinence, low dietary intake of vitamin C, elevated catecholamine levels, and being introverted were all associated with greater susceptibility to colds, they could only partially account for the relation between social network diversity and incidence of colds. <h3>Conclusions.</h3> —More diverse social networks were associated with greater resistance to upper respiratory illness.
Council on Pharmacy and Chemistry
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Books Received
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
X-Ray Interpretation. By H. Cecil H. Bull, M.A., M.B., M.R.C.P
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
March 27, 2002
Journal: JAMA (2002)

Shiliang Liu, MB, PhD; K. S. Joseph, MD, PhD; Michael S. Kramer, MD; Alexander C. Allen, MD; Reg Sauve, MD, MPH; I. D. Rusen, MD, MSc; Shi Wu Wen, MB, PhD; for the Fetal and Infant Health Study Group of the Canadian Perinatal Surveillance System
Correction: Negative Regulation of the Hippo Pathway by E3 Ubiquitin Ligase ITCH Is Sufficient to Promote Tumorigenicity
Authors: Zaidoun Salah, Gerry Melino, Rami I. Aqeilan
Journal: Cancer Research (2019)

In the original version of this article (1), an error occurred in figure assembly during manuscript preparation, resulting in a duplication between the 0 hour control and ITCH Sh89 panels in Fig. 5B. The error has been corrected in the latest online HTML and PDF versions of the article. The authors regret this error.
Does taking vitamins at the time of conception prevent neural tube defects?
Authors: L. B. Holmes
Journal: JAMA (1988)

The prevention of birth defects is discussed frequently but achieved rarely. Mulinare et al<sup>1</sup>report, in this issue ofTHE JOURNAL, the exciting possibility that the occurrence of anencephaly and spina bifida may be prevented if the pregnant woman takes a multivitamin preparation around the time of conception. Such a simple solution is almost too good to be true. To their credit, Mulinare et al outline several concerns and reservations about their findings. Most important of all, we need confirmation of this finding from other studies. At this time, spina bifida and anencephaly, the most common of the neural tube defects, occur almost always as a surprise in the children of healthy parents. The defects are present by the fourth week of gestation, which is often before the woman knows she is pregnant. If all women were taking a multivitamin preparation at the time of conception, would this birth
Cyanide production from laetrile in the presence of megadoses of ascorbic acid
Authors: R. C. Backer
Journal: JAMA (1979)

<h3>To the Editor.—</h3> As previously reported inThe Journal(240:1139, 1978), the "antineoplastic diet" of laetrile proponents calls for megadoses of ascorbic acid (vitamin C) among other dietary requirements. We performed a series of experiments designed to see if ascorbic acid would increase the hydrolysis of laetrile (amygdalin) to benzaldehyde and hydrocyanic acid (HCN), and therefore increase the probability that the patient would suffer from cyanide poisoning while receiving laetrile therapy. Six Conway microdiffusion cells were prepared as shown in the Table. A plastic cover was sealed in place with a water-soluble starch-glycerol paste. The sealed cells were incubated at 37 °C for one hour and then left an additional hour at room temperature. The potassium hydroxide solutions were then analyzed for cyanide levels by the method of Valentour.<sup>1</sup>The results are also shown in the Table. The Table shows that the presence of ascorbic acid did increase the
Small GTPase RBJ mediates nuclear entrapment of MEK1/MEK2 in tumor progression
Authors: Taoyong Chen, Mingjin Yang, Zhou Yu, Songqing Tang, Chen Wang, Xuhui Zhu, Jun Guo, Nan Li, Weiping Zhang, Jin Hou, Haibo Liu, Chaofeng Han, Qiuyan Liu, Yan Gu, Cheng Qian, Tao Wan, Long Cui, Minghua Zhu, Weiqiang Zheng, Xuetao Cao
Journal: Cancer Cell (2021)
Live Attenuated Varicella Vaccine
Authors: Anne A. Gershon
Journal: JAMA (1984)

One hundred ninety-one varicella-susceptible children with leukemia in remission were immunized with live attenuated varicella vaccine. There was serological evidence of an immune response in approximately 80% after one dose and in more than 90% after two doses. The major side effect was mild to moderate rash, seen especially in children with maintenance chemotherapy suspended for one week before and one week after vaccination. Children with rash had higher antibody titers than those without rash, but those with rash were also at risk (10%) to transmit vaccine virus to others. Twenty-two vaccinees subsequently had household exposures to varicella or zoster. The attack rate of clinical varicella in these vaccinees was 18%, significantly lower than the attack rate of approximately 90% in varicella-susceptible persons with household exposures. All cases of clinical illness were extremely mild, with an average of about 50 vesicles. The mild character of the illness was clearly different than varicella in unimmunized children receiving chemotherapy for leukemia. Varicella vaccine was approximately 80% effective in preventing clinical varicella in children with leukemia and completely effective in preventing severe varicella in this high-risk group. (<i>JAMA</i>1984;252:355-362)
Cultural Exchange
Authors: Jack Coulehan
Journal: Annals of Internal Medicine (2020)

Ad Libitum21 January 2020Cultural ExchangeJack Coulehan, MDJack Coulehan, MDCenter for Medical Humanities, Compassionate Care, and Bioethics at Stony Brook University, Stony Brook, New York (J.C.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M19-0932 Audio Reading - “Cultural Exchange” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “Cultural Exchange” by Jack Coulehan, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Mmatseke, South AfricaThe Cuban doctor intends to amazethe visitor with the guinea wormhe's winding from Mkale's abdomenonto a dial stick, each dayturning a single time. And the scanfrom the Cape—echinococcal cystsblossoming in Dikobo's liver.He's brought a tin of tea biscuitsto offer the American doctor,whose diffidence disappoints him.He had expected them all to beloud and physically large. This onemight be concealing arrogance,but the Cuban is masking distain.The American lavishes praiseon Cuban advances. He dismisseshis own nation's excessive spendingon medical fads and foolishness.When he complements the hospital'scleanliness, fatigue radiatesof new patients is pulling ... Author, Article, and Disclosure InformationAffiliations: Center for Medical Humanities, Compassionate Care, and Bioethics at Stony Brook University, Stony Brook, New York (J.C.)Current Author Address: Jack Coulehan, MD; e-mail, john.[email protected]edu. PreviousarticleNextarticle Advertisement Audio Reading - “Cultural Exchange” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “Cultural Exchange” by Jack Coulehan, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics Cited byThe Genetic Structure and East-West Population Admixture in Northwest China Inferred From Genome-Wide Array Genotyping 21 January 2020Volume 172, Issue 2Page: 158KeywordsBrainFatigueLiverTea ePublished: 21 January 2020 Issue Published: 21 January 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Medicolegal
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Staging of breast cancer and survival rates
Authors: C. M. Sutherland
Journal: JAMA (1983)

<h3>To the Editor.—</h3> We read the article by Ferguson and associates in the Sept 17 issue entitled "Staging of Breast Cancer and Survival Rates" (1982;248:1337). The authors are to be congratulated for providing us with valuable information in this difficult area of evaluating the long-term effects of breast cancer. However, we must question the use of relative survival rates to determine the long-range effects of breast cancer. The relative survival rate at time X is given by the following equation: Probability of Surviving in Study Population to Time X/ Probability of Surviving in Control Population to Time X This ratio is then the proportion of the population escaping the<i>excess</i>(not absolute) risk of death caused by breast cancer if the risk of death by other causes is equal in both the study and the general population. It is known that patients from higher socioeconomic conditions have lower death rates
Microtubule-Associated Proteins: Their Potential Role In Determining Neuronal Morphology
Authors: A Matus
Journal: Annual Review of Neuroscience (1988)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
Author' response
Authors: K. L ENGLER
Journal: Cardiovascular Research (1993)

Journal Article Author' response Get access KOBERT L ENGLER KOBERT L ENGLER UCSD School of Medicine ACOS for Research San Diego VAMC, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 27, Issue 5, May 1993, Page 730, https://doi.org/10.1093/cvr/27.5.730 Published: 01 May 1993 Article history Received: 07 July 1992 Accepted: 28 October 1992 Published: 01 May 1993
State Boards of Registration.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Eighth European Symposium on Hormones and Cell Regulation
Journal: JNCI Journal of the National Cancer Institute (1983)

Journal Article Eighth European Symposium on Hormones and Cell Regulation Get access JNCI: Journal of the National Cancer Institute, Volume 70, Issue 5, May 1983, Page 987, https://doi.org/10.1093/jnci/70.5.987-c Published: 01 May 1983
Polymorphic light eruption sine eruptione
Authors: J.S. Dover, M.A. Garmyn, J.L.M. Hawk
Journal: British Journal of Dermatology (1985)

Seven patients, four female and three male, who develop intense pruritus without visible skin changes in light‐exposed areas after sun exposure are reviewed. Onset in all cases has been in childhood or adolescence and the condition has persisted indefinitely except in one patient who has been in remission‐for I year and one who was in remission for 5 years before relapse. Itching occurs on sun‐exposed areas within 45 min to 24 h and lasts for 1–5 days. No patient has taken photosensitizing medications or suffered from any significant systemic illness. There is a positive family history of polymorphic light eruption (PLE) in one, and of sunlight‐induced pruritus in another. Porphyrin studies and antinuclear factor titres are normal. Cutaneous phototesting of the back by monochromator is normal in the UV‐B, UV‐A and visible light ranges. Irradiation from a xenon arc solar simulator in one patient induced intense pruritus with no visible skin changes on the tested sites of the anterior forearm and back in a time course mimicking that of sun‐induced symptoms. Treatment by sun avoidance, topical sunscreens and antihistamines has been only partially effective. Two patients have subsequently developed occasional typical PLE upon sun exposure, but sun‐induced pruritus alone occurs most frequently. This suggests that polymorphic light eruption sine eruptione is a variant of PLE and, to our knowledge, is the first report of this condition.
Hepatocellular carcinoma in patients with autoimmune hepatitis: prevalence and risk factors
Authors: Nayana Fonseca Vaz, Julia Fadini Margon, Bruna Damasio Moutinho, Michele Harriz Braga, Claudia Megumi Tani, Regiane Saraiva de Souza Melo Alencar, Lisa Rodrigues da Cunha Saud, Denise Cerqueira Paranaguá Vezozzo, Marta Deguti, Natally Horvat, Eduardo Luiz Rachid Cançado, Flair Jose Carrilho, Aline Lopes Chagas, Débora Terrabuio
Journal: Journal of Hepatology (2020)
Reverse targeting of preventive care due to lack of health insurance
Authors: S. Woolhandler
Journal: JAMA (1988)

We analyzed patterns of receipt of preventive services among middle-aged women, with particular attention to health insurance coverage, based on data from the National Health Interview Survey. Lack of insurance was most prevalent among socioeconomically disadvantaged women at high risk for disease and was the strongest predictor of failure to receive screening tests. The relative risk of inadequate screening for uninsured compared with insured women was 1.60 (95% confidence interval [CI], 1.40 to 1.83) for blood pressure checkups, 1.55 (95% CI, 1.43 to 1.68) for cervical smears, 1.52 (95% CI, 1.41 to 1.63) for glaucoma testing, and 1.42 (95% CI, 1.33 to 1.51) for clinical breast examination. Controlling for demographic and health status variables did not diminish the effect of insurance coverage. We conclude that inadequate insurance coverage leads to "reverse targeting" of preventive care—that is, populations at highest risk are least likely to be screened. This compromises both the effectiveness and the cost-effectiveness of screening. (<i>JAMA</i>1988;259:2872-2874)
Contents
Authors: Hana Takusagawa, Liang Liu, Kelly Ma, Yali Jia, Simon Gao, Miao Zhang, Beth Edmunds, Mansi Parikh, Shandiz Tehrani, John Morrison, David Huang, Yu Sawada, Makoto Araie, Makoto Ishikawa, Takeshi Yoshitomi, Jithin Yohannan, Jiangxia Wang, Jamie Brown, Balwantray Chauhan, Michael Boland, David Friedman, Pradeep Ramulu, John Guy, William Feuer, Janet Davis, Vittorio Porciatti, Phillip Gonzalez, Rajeshwari Koilkonda, Huijun Yuan, William Hauswirth, Byron Lam, Claudia Becker, Susan Jick, Christoph Meier, Steven Brooks, June Lee, Hae Kim, Ki Park, Yong Kim, Michael Girard, Jean Martial Mari, Seung-Ki Kim, Ji Phi, Jin Jeoung, Thomas Oetting
Journal: Ophthalmology (2017)