tbuckley/cabot-search huggingface dataset:
Doxycycline versus azithromycin for the treatment of anorectal Chlamydia trachomatis infection in women concurrent with vaginal infection (CHLAZIDOXY study): a multicentre, open-label, randomised, controlled, superiority trial
Authors: Olivia Peuchant, Edouard Lhomme, Pervenche Martinet, Anne Grob, Dounia Baïta, Claire Bernier, Sophie Anne Gibaud, Isabelle Le Hen, Erwan Le Naour, Nathalie Trignol-Viguier, Philippe Lanotte, Philippe Lefebvre, Anne Vachée, Thomas Girard, Julien Loubinoux, Cécile Bébéar, Bellabes Ghezzoul, Caroline Roussillon, Marion Kret, Bertille de Barbeyrac, Catherine Ouziel-Duretz, Béatrice Poudens, Raquel Brun, Sophie Jouvert, Aurore Tesson, Jennifer Carrière, Marie Diaz, Camille Forget, France Ahano-Ducourneau, Delphine Ha Van, Pauline Robert, Fabienne Brun, Estelle Lhospital, Julie Bardou, Annaïg Guegan, Sandy Ramloll Moura, Céline Leriche, Alix De Cussy, Marlène Malfait, Charlotte Rychen, Audrey Kugeler, Lisa Barriere, Laura Gutierrez, Jean-Luc Robert, Julie Saule, Viviana Bergamaschi, Sana Ben Soltana, Dominique Aymar-Moulene, Anne-Sophie Lecompte, Antoine Grégoire, Marie-Astrid Naccache, Pauline Crombe, Christine Bulot, Anne-Laure Rolland, Elisabeth Blin-Zbiegiel, Mélanie Boissinot, Bruno Joly, Anne Dubreuil, Camille Mathieu, David Pragout, Sophie Zaffreya, Arabella Touati, Carla Balcon, Frédéric Perry, Christelle Turuban, Sabine Rapin, Christine Pastor, Morane Cavellec, Ernesto Paredes Manyari, Soria Albane, Katy Dernivoix, Camille Trouillet, Eva Ghiringelli, Karen Pantin, Damien Garreau, Jérôme Galet
Journal: The Lancet Infectious Diseases (2022)
Favorable vaccine-induced SARS-CoV-2–specific T cell response profile in patients undergoing immune-modifying therapies
Authors: Martin Qui, Nina Le Bert, Webber Pak Wo Chan, Malcolm Tan, Shou Kit Hang, Smrithi Hariharaputran, Jean Xiang Ying Sim, Jenny Guek Hong Low, Weiling Ng, Wei Yee Wan, Tiing Leong Ang, Antonio Bertoletti, Ennaliza Salazar
Journal: Journal of Clinical Investigation (2022)

BACKGROUNDPatients undergoing immune-modifying therapies demonstrate a reduced humoral response after COVID-19 vaccination, but we lack a proper evaluation of the effect of such therapies on vaccine-induced T cell responses.METHODSWe longitudinally characterized humoral and spike-specific T cell responses in patients with inflammatory bowel disease (IBD), who were on antimetabolite therapy (azathioprine or methotrexate), TNF inhibitors, and/or other biologic treatment (anti-integrin or anti-p40) for up to 6 months after completing 2-dose COVID-19 mRNA vaccination.RESULTSWe demonstrate that a spike-specific T cell response was not only induced in treated patients with IBD at levels similar to those of healthy individuals, but also sustained at higher magnitude for up to 6 months after vaccination, particularly in those treated with TNF inhibitor therapy. Furthermore, the spike-specific T cell response in these patients was mainly preserved against mutations present in SARS-CoV-2 B.1.1.529 (Omicron) and characterized by a Th1/IL-10 cytokine profile.CONCLUSIONDespite the humoral response defects, patients under immune-modifying therapies demonstrated a favorable profile of vaccine-induced T cell responses that might still provide a layer of COVID-19 protection.FUNDINGThis study was funded by the National Centre for Infectious Diseases (NCID) Catalyst Grant (FY2021ES) and the National Research Fund Competitive Research Programme (NRF-CRP25-2020-0003).
Breakthrough SARS-CoV-2 infections with the delta (B.1.617.2) variant in vaccinated patients with immune-mediated inflammatory diseases using immunosuppressants: a substudy of two prospective cohort studies
Authors: Laura Boekel, Eileen W Stalman, Luuk Wieske, Femke Hooijberg, Koos P J van Dam, Yaëlle R Besten, Laura Y L Kummer, Maurice Steenhuis, Zoé L E van Kempen, Joep Killestein, Adriaan G Volkers, Sander W Tas, Anneke J van der Kooi, Joost Raaphorst, Mark Löwenberg, R Bart Takkenberg, Geert R A M D'Haens, Phyllis I Spuls, Marcel W Bekkenk, Annelie H Musters, Nicoline F Post, Angela L Bosma, Marc L Hilhorst, Yosta Vegting, Frederike J Bemelman, Alexandre E Voskuyl, Bo Broens, Agner Parra Sanchez, Cécile A C M van Els, Jelle de Wit, Abraham Rutgers, Karina de Leeuw, Barbara Horváth, Jan J G M Verschuuren, Annabel M Ruiter, Lotte van Ouwerkerk, Diane van der Woude, Cornelia F Allaart, Y K Onno Teng, Pieter van Paassen, Matthias H Busch, Papay B P Jallah, Esther Brusse, Pieter A van Doorn, Adája E Baars, Dirk Jan Hijnen, Corine R G Schreurs, W Ludo van der Pol, H Stephan Goedee, Erik H Vogelzang, Maureen Leeuw, Sadaf Atiqi, Ronald van Vollenhoven, Martijn Gerritsen, Irene E van der Horst-Bruinsma, Willem F Lems, Mike T Nurmohamed, Maarten Boers, Sofie Keijzer, Jim Keijser, Carolien van de Sandt, Arend Boogaard, Olvi Cristianawati, Anja ten Brinke, Niels J M Verstegen, Koos A H Zwinderman, S Marieke van Ham, Theo Rispens, Taco W Kuijpers, Gertjan Wolbink, Filip Eftimov, Rivka de Jongh, Carolien van de Sandt, Lisan Kuijper, Mariel Duurland, Ruth Hagen, Jet van den Dijssel, Christine Kreher, Amelie Bos, Viriginia Palomares Cabeza, Veronique Konijn, George Elias, Juan Vallejo, Marrit van Gils, Tom Ashhurst, Sergey Nejentsev, Elham Mirfazeli
Journal: The Lancet Rheumatology (2022)
Single-cell profiling of human dura and meningioma reveals cellular meningeal landscape and insights into meningioma immune response
Authors: Anthony Z. Wang, Jay A. Bowman-Kirigin, Rupen Desai, Liang-I Kang, Pujan R. Patel, Bhuvic Patel, Saad M. Khan, Diane Bender, M. Caleb Marlin, Jingxian Liu, Joshua W. Osbun, Eric C. Leuthardt, Michael R. Chicoine, Ralph G. Dacey, Gregory J. Zipfel, Albert H. Kim, David G. DeNardo, Allegra A. Petti, Gavin P. Dunn
Journal: Genome Medicine (2022)

Recent investigations of the meninges have highlighted the importance of the dura layer in central nervous system immune surveillance beyond a purely structural role. However, our understanding of the meninges largely stems from the use of pre-clinical models rather than human samples.
Temperamental and Theoretical Contributions to Clinical Psychology
Authors: Jerome Kagan
Journal: Annual Review of Clinical Psychology (2022)

This review considers two themes. The first section describes the influence of two temperamental biases detectable in infants that render children vulnerable to maladaptive behavior if the rearing environment invites such responses. Infants who display high levels of limb activity and crying in response to unexpected events are likely to be shy and fearful as children and are at risk for an anxiety disorder. Infants who display little limb movement and crying are susceptible to assuming risks and vulnerable to asocial behavior if the rearing environment invites these actions. The second section criticizes three common research practices: failure to examine patterns of measures for predictors and outcomes, an indifference to the power of the setting on the evidence recorded, and the distortions that semantic terms in questionnaires impose on replies.
From the past zemstvo medicine in the outback: Zhovte village in Katerynoslavshchina
Authors: M.P. Chaban, Z.I. Shevtsova, V.V. Gaponov
Journal: GASTROENTEROLOGY (2022)

The article covers the formation of zemstvo medicine in the Verkhnyodniprovskdistrict of Ekaterinoslav province on the example of the village Zhovte. Historical and local lore information about this region has been provided. The development of the medical service in the early twentieth century has been presented. The life and professional path of ascetic physicians Mykhailo Dudkevych, Gavrilo Kossovsky, Volodymyr Tatarynov and others have been studied.
A glucose-like metabolite deficient in diabetes inhibits cellular entry of SARS-CoV-2
Authors: Liangqin Tong, Xiaoping Xiao, Min Li, Shisong Fang, Enhao Ma, Xi Yu, Yibin Zhu, Chunli Wu, Deyu Tian, Fan Yang, Jing Sun, Jing Qu, Nianzhen Zheng, Shumin Liao, Wanbo Tai, Shengyong Feng, Liming Zhang, Yuhan Li, Lin Wang, Xuelian Han, Shihui Sun, Long Yang, Hui Zhong, Jincun Zhao, Wenjun Liu, Xiaohui Liu, Penghua Wang, Liang Li, Guangyu Zhao, Renli Zhang, Gong Cheng
Journal: Nature Metabolism (2022)
Clinical and radiological improvement of protracted COVID-19 and Good syndrome secondary to advanced thymoma
Authors: M. Tenorio Cerezoli, J.A. Gonçalves Garreta Prats, A. Kreling Medeiros, D.V. Gonçalves Santana, F. Marques da Costa, U.S. Torres, W.N. William Jr.
Journal: Pulmonology (2022)
The European response to control and manage multi- and extensively drug-resistant Neisseria gonorrhoeae
Authors: Michelle J Cole, Michaela Day, Susanne Jacobsson, Andrew J Amato-Gauci, Gianfranco Spiteri, Magnus Unemo
Journal: Eurosurveillance (2022)

Because cefixime and ceftriaxone resistance in Neisseria gonorrhoeae and gonorrhoea treatment failures were increasing, a response plan to control and manage multidrug-resistant N. gonorrhoeae (MDR-NG) in Europe was published in 2012. The three main areas of the plan were to: (i) strengthen surveillance of antimicrobial resistance (AMR), (ii) implement monitoring of treatment failures and (iii) establish a communication strategy to increase awareness and disseminate AMR results. Since 2012, several additional extensively drug-resistant N. gonorrhoeae (XDR-NG) strains have emerged, and strains with high-level ceftriaxone resistance spread internationally. This prompted an evaluation and review of the 2012 European Centre for Disease Prevention and Control (ECDC) response plan, revealing an overall improvement in many aspects of monitoring AMR in N. gonorrhoeae; however, treatment failure monitoring was a weakness. Accordingly, the plan was updated in 2019 to further support European Union/European Economic Area (EU/EEA) countries in controlling and managing the threat of MDR/XDR-NG in Europe through further strengthening of AMR surveillance and clinical management including treatment failure monitoring. The plan will be assessed biennially to ensure its effectiveness and its value. Along with prevention, diagnostic, treatment and epidemiological surveillance strategies, AMR surveillance is essential for effective control of gonorrhoea.
Phosphoinositide-Binding Protein TIPE1 Promotes Alternative Activation of Macrophages and Tumor Progression via PIP3/Akt/TGFβ Axis
Authors: Yang Cheng, Fuxiang Bai, Xiaolei Ren, Renhui Sun, Xiaowei Guo, Wen Liu, Bo Wang, Yongheng Yang, Xiaolu Zhang, Yong Xu, Chunyang Li, Xiaoyun Yang, Lifen Gao, Chunhong Ma, Xueen Li, Xiaohong Liang
Journal: Cancer Research (2022)

Macrophages perform key and distinct functions in maintaining tissue homeostasis by finely tuning their activation state. Within the tumor microenvironment, macrophages are reshaped to drive tumor progression. Here we report that tumor necrosis factor α-induced protein 8-like 1 (TIPE1) is highly expressed in macrophages and that depletion of TIPE1 impedes alternative activation of macrophages. TIPE1 enhanced activation of the PI3K/Akt pathway in macrophages by directly binding with and regulating the metabolism of phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). Accordingly, inhibition of the PI3K/Akt pathway significantly attenuated the effect of TIPE1 on macrophage alternative activation. Tumor-associated macrophages (TAM) in human liver cancer and melanoma tissues showed significantly upregulated TIPE1 expression that negatively correlated with patient survival. In vitro and in vivo, TIPE1 knockdown in macrophages retarded the growth and metastasis of liver cancer and melanoma. Furthermore, blockade or depletion of TGFβ signaling in macrophages abrogated the effects of TIPE1 on tumor cell growth and migration. Together, these results highlight that the phosphoinositide-related signaling pathway is involved in reprogramming TAMs to optimize the microenvironment for cancer progression.This work provides insight into the fine tuning of macrophage polarization and identifies a potential target for macrophage-based antitumor therapy.
Bridging the gap with the UK Genomics Pathology Imaging Collection
Authors: Charlotte N. Jennings, Matthew P. Humphries, Suzanne Wood, Monit Jadhav, Robbie Chabra, Christopher Brown, Georgia Chan, Danny Kaye, Daljeet Bansal, Catherine Colquhoun, Nour Merzouki, Prabhu Arumugam, David R. Westhead, Darren Treanor
Journal: Nature Medicine (2022)
Promoting the genomic revolution in Africa through the Nigerian 100K Genome Project
Authors: Segun Fatumo, Aminu Yakubu, Olubukunola Oyedele, Jumi Popoola, Delali Attiogbe Attipoe, Golibe Eze-Echesi, Fatima Z Modibbo, Nabila Ado-Wanka, Yemisi Osakwe, Onome Braimah, Eramoh Julius-Enigimi, Terver Mark Akindigh, Bolutife Kusimo, Chinenye Akpulu, Chiamaka Nwuba, Ofonime Ebong, Chinyere Anyika, Oluwatimilehin Adewunmi, Yusuf Ibrahim, Janet Kashimawo, Ogochukwu Francis Osifo, Chidi Nkwocha, Peter Iyitor, Temi Abiwon, Adeola Adeleye, Abayomi Ode, Anjola Ayo-Lawal, Kasiena Akpabio, Emame Edu, Chiemela Njoku, Bari Ballew, Cameron Palmer, Abdullahi Musa, Abdulrasheed M. Mujtaba, Abiodun Popoola, Abubakar M. Bello, Anthony Anyanwu, Ashiru Yusuf, Gesiye EL Bozimo, Goddy Bassey, Hadiza Bala, Istifanus Bala Bosan, Jemimah Edah, Mutiu Alani Jimoh, Kenneth Nwankwo, Olalekan Ojo, Marcus Inyama, Maryam Apanpa, Mohammed Mustapha, Musa Ali-Gombe, Olubukola Ojo, Oludare Adeyemi, Samuel Ajayi, Sanusi Bala, Temitope Ojo, Usman Malami Aliyu, Yemi Raji, Zainab Tanko, Amina Mohammed, David Oladele, Muhammed Hamzat, Emmanuel Agaba, Emeka Nwankwo, Ifeoma Ulasi, Jonah Musa, Umeora Odidika, Omolola Salako, Oyekanmi Nashiru, Babatunde L Salako, Colm O’Dushlaine, Abasi Ene-Obong
Journal: Nature Genetics (2022)
Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker
Authors: Aslan Mansurov, Peyman Hosseinchi, Kevin Chang, Abigail L. Lauterbach, Laura T. Gray, Aaron T. Alpar, Erica Budina, Anna J. Slezak, Seounghun Kang, Shijie Cao, Ani Solanki, Suzana Gomes, John-Michael Williford, Melody A. Swartz, Juan L. Mendoza, Jun Ishihara, Jeffrey A. Hubbell
Journal: Nature Biomedical Engineering (2022)
Care of the Patient After Metabolic and Bariatric Surgery
Authors: Carolyn Bramante, Eric Wise, Zoobia Chaudhry
Journal: Annals of Internal Medicine (2022)

Weight loss surgery, also known as metabolic and bariatric surgery (MBS), is an effective weight loss treatment and is associated with reduced mortality and improvements in obesity-related health conditions and quality of life. Postsurgical anatomical and physiologic changes include decreased absorption of micronutrients and alterations in gut–brain hormonal regulation that affect many aspects of health. Patients require ongoing monitoring of their physical and mental health for lasting success. Internists, particularly primary care clinicians, are in an ideal position to monitor for nonserious complications in the short and long term, adjust management of chronic diseases accordingly, and monitor for mental health changes. This article reviews key issues that internists should be aware of for supporting patients' health in the short and long term after MBS.
Screening for Chronic Obstructive Pulmonary Disease
Authors: Elizabeth M. Webber, Jennifer S. Lin, Rachel G. Thomas
Journal: JAMA (2022)

<h3>Importance</h3> Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality in the US. <h3>Objective</h3> To conduct a targeted systematic review to update the evidence on the effectiveness of screening for COPD and the treatment of COPD to inform the US Preventive Services Task Force (USPSTF) update of the 2016 recommendation statement on COPD screening. <h3>Data Sources</h3> MEDLINE, the Cochrane Central Register of Controlled Trials, and CINAHL for relevant studies published between January 1, 2015, to January 22, 2021; surveillance through March 25, 2022. <h3>Study Selection</h3> English-language studies of screening in individuals who do not recognize or report respiratory symptoms; studies of treatment in persons with mild or moderate, or minimally symptomatic, COPD. <h3>Data Extraction and Synthesis</h3> Two reviewers independently appraised the articles and extracted relevant data from fair- or good-quality studies; no quantitative synthesis was conducted. <h3>Main Outcomes and Measures</h3> COPD-related morbidity or mortality, measures of health-related quality of life, and adverse events. <h3>Results</h3> The review included no trials on the effectiveness of screening, 3 trials or analyses (n = 20 058) of pharmacologic treatment published since 2015, 13 trials (n = 3657) on nonpharmacologic interventions, and 2 large observational studies (n = 243 517) addressing the harms of pharmacologic treatment published since 2015. The results from the clinical trials of pharmacologic therapy are consistent with the previous review supporting the USPSTF that bronchodilators with or without inhaled corticosteroids can reduce COPD exacerbations and tiotropium can improve health-related quality of life in adults with moderate COPD. Overall, there was no consistent benefit observed for any type of nonpharmacologic intervention across a range of patient outcomes. None of the included treatment trials that reported adverse effects found significant harms. Two large observational studies in a screen-relevant population demonstrated an association of the initiation of a long-acting muscarinic antagonist or long-acting beta agonist with the risk of a serious cardiovascular event in treatment-naïve patients and an association of inhaled corticosteroids use with the risk of developing diabetes. <h3>Conclusions and Relevance</h3> The findings of this targeted evidence update are generally consistent with the findings of the previous systematic review supporting the 2016 USPSTF recommendation. Evidence of pharmacologic treatment was still largely limited to persons with moderate airflow obstruction, and there was no consistent benefit observed for a range of nonpharmacologic interventions in mild to moderate COPD or in minimally symptomatic persons with COPD.
Case 13-2022: A 56-Year-Old Man with Myalgias, Fever, and Bradycardia
Authors: Molly L. Paras, Shaan Khurshid, Borek Foldyna, Alex L. Huang, Elizabeth L. Hohmann, Leslie T. Cooper, Bianca B. Christensen
Journal: New England Journal of Medicine (2022)

A 56-year-old man presented in early autumn with a 1-month history of myalgias and fever. His heart rate was 48 beats per minute. An electrocardiogram showed sinus bradycardia and complete heart block; cardiac imaging showed inflammatory changes in the epicardial fat abutting the noncoronary sinus of the aortic valve. A diagnostic test was performed.
FAM64A promotes HNSCC tumorigenesis by mediating transcriptional autoregulation of FOXM1
Authors: Xinyuan Zhao, Huan Chen, Yu Qiu, Li Cui
Journal: International Journal of Oral Science (2022)

Abstract Head and neck squamous cell carcinoma (HNSCC) still lacks effective targeted treatment. Therefore, exploring novel and robust molecular targets is critical for improving the clinical outcome of HNSCC. Here, we reported that the expression levels of family with sequence similarity 64, member A (FAM64A) were significantly higher in HNSCC tissues and cell lines. In addition, FAM64A overexpression was found to be strongly associated with an unfavorable prognosis of HNSCC. Both in vitro and in vivo evidence showed that FAM64A depletion suppressed the malignant activities of HNSCC cells, and vice versa. Moreover, we found that the FAM64A level was progressively increased from normal to dysplastic to cancerous tissues in a carcinogenic 4-nitroquinoline-1-oxide mouse model. Mechanistically, a physical interaction was found between FAM64A and forkhead box protein M1 (FOXM1) in HNSCC cells. FAM64A promoted HNSCC tumorigenesis not only by enhancing the transcriptional activity of FOXM1, but also, more importantly, by modulating FOXM1 expression via the autoregulation loop. Furthermore, a positive correlation between FAM64A and FOXM1 was found in multiple independent cohorts. Taken together, our findings reveal a previously unknown mechanism behind the activation of FOXM1 in HNSCC, and FAM64A might be a promising molecular therapeutic target for treating HNSCC.
Association Between Toy Type and Parent Language Input Provided to Children With Autism Spectrum Disorder and Age-Matched Children With Typical Development
Authors: Mackenzie Sturman, Kendra Peffers, Jennifer R. Johnson, Courtney E. Venker
Journal: JAMA Pediatrics (2022)

This comparative effectiveness research study evaluates the association between toy type and parent language input during play with children with autism spectrum disorder (ASD) and those with typical development.
Peri-intubation Cardiovascular Collapse in Patients Who Are Critically Ill: Insights from the INTUBE Study
Authors: Vincenzo Russotto, Elena Tassistro, Sheila N. Myatra, Matteo Parotto, Laura Antolini, Philippe Bauer, Jean Baptiste Lascarrou, Konstanty Szułdrzyński, Luigi Camporota, Christian Putensen, Paolo Pelosi, Massimiliano Sorbello, Andy Higgs, Robert Greif, Antonio Pesenti, Maria Grazia Valsecchi, Roberto Fumagalli, Giuseppe Foti, Giacomo Bellani, John G. Laffey
Journal: American Journal of Respiratory and Critical Care Medicine (2022)

Rationale: Cardiovascular instability/collapse is a common peri-intubation event in patients who are critically ill. Objectives: To identify potentially modifiable variables associated with peri-intubation cardiovascular instability/collapse (i.e., systolic arterial pressure <65 mm Hg [once] or <90 mm Hg for >30 minutes; new/increased vasopressor requirement; fluid bolus >15 ml/kg, or cardiac arrest). Methods: INTUBE (International Observational Study to Understand the Impact and Best Practices of Airway Management In Critically Ill Patients) was a multicenter prospective cohort study of patients who were critically ill and undergoing tracheal intubation in a convenience sample of 197 sites from 29 countries across five continents from October 1, 2018, to July 31, 2019. Measurements and Main Results: A total of 2,760 patients were included in this analysis. Peri-intubation cardiovascular instability/collapse occurred in 1,199 out of 2,760 patients (43.4%). Variables associated with this event were older age (odds ratio [OR], 1.02; 95% confidence interval [CI], 1.02-1.03), higher heart rate (OR, 1.008; 95% CI, 1.004-1.012), lower systolic blood pressure (OR, 0.98; 95% CI, 0.98-0.99), lower oxygen saturation as measured by pulse oximetry/FiO2 before induction (OR, 0.998; 95% CI, 0.997-0.999), and the use of propofol as an induction agent (OR, 1.28; 95% CI, 1.05-1.57). Patients with peri-intubation cardiovascular instability/collapse were at a higher risk of ICU mortality with an adjusted OR of 2.47 (95% CI, 1.72-3.55), P < 0.001. The inverse probability of treatment weighting method identified the use of propofol as the only factor independently associated with cardiovascular instability/collapse (OR, 1.23; 95% CI, 1.02-1.49). When administered before induction, vasopressors (OR, 1.33; 95% CI, 0.84-2.11) or fluid boluses (OR, 1.17; 95% CI, 0.96-1.44) did not reduce the incidence of cardiovascular instability/collapse. Conclusions: Peri-intubation cardiovascular instability/collapse was associated with an increased risk of both ICU and 28-day mortality. The use of propofol for induction was identified as a modifiable intervention significantly associated with cardiovascular instability/collapse.Clinical trial registered with clinicaltrials.gov (NCT03616054).
Serrated polyp detection and risk of interval post-colonoscopy colorectal cancer: a population-based study
Authors: David E F W M van Toledo, Joep E G IJspeert, Patrick M M Bossuyt, Arne G C Bleijenberg, Monique E van Leerdam, Manon van der Vlugt, Iris Lansdorp-Vogelaar, Manon C W Spaander, Evelien Dekker
Journal: The Lancet. Gastroenterology & hepatology (2022)