Sucralfate
Authors: CHARLES T. RICHARDSON
Journal: Annals of Internal Medicine (1982)

Editorials1 August 1982SucralfateCHARLES T. RICHARDSON, M.D.CHARLES T. RICHARDSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-2-269 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSucralfate has been approved by the Food and Drug Administration for use in treating patients with active duodenal ulcers. Although sucralfate is new in the United States, it has been used for several years in Japan. Sucralfate neither reduces acid secretion nor neutralizes acid. Instead, it is believed to act primarily at the ulcer crater, forming a protective coat that shields the lesion from pepsin and, perhaps, acid (1-3).Sucralfate is the salt of sucrose octasulfate- and [A12(OH)5]+. When the drug reaches the acidic environment (pH, < 3 to 4) of the stomach, some [A12(OH)5] + ions dissociate from sucrose...References1. NAGASHIMA R. Development and characteristics of sucralfate. J Clin Gastroenterol. 1981;3(suppl 2):103-10. MedlineGoogle Scholar2. NAGASHIMA R. Mechanisms of action of sucralfate. J Clin Gastroenterol. 1981;3(suppl 2):117-27. MedlineGoogle Scholar3. MCGRAW B and CALDWELL E. Sucralfate. Drug Intelligence Clin Pharm. 1981;15:578-80. CrossrefMedlineGoogle Scholar4. NAGASHIMA R, HINOHARA Y, and HIRANO T. Selective binding of sucralfate to ulcer lesion: III. Experiments in rats with duodenal ulcer receiving 14C-sucralfate. Arzneim Forsch. 1980;30:88-91. MedlineGoogle Scholar5. GIESING D, BIGHLEY L, and ILES R. Effect of food and antacid on binding of sucralfate to normal and ulcerated gastric and duodenal mucosa in rats. J Clin Gastroenterol. 1981;3(suppl 2):111-6. MedlineGoogle Scholar6. NAKAZAWA S, NAGASHIMA R, and SAMLOFF I. Selective binding of sucralfate to gastic ulcer in man. Dig Dis Sci. 1981;26:297-300. CrossrefMedlineGoogle Scholar7. MASUDA M, TANIGUCHI M, TAKAFUJI H, ULDA M, SUZUKI S, and MORINO T. Clinical effect of ulcermin on peptic ulcer. Shinyro (Diagnosis and Therapy). 1970;23:93-8. Google Scholar8. TERAO N, YOSHIDA N, and NAGASHIMA R. Sucralfate, a basic salt of sucrose sulfate: III. Inhibition of peptic hydrolysis of fibrinogen by sucrose sulfate. Arzneim Forsch. 1980;30:76-8. MedlineGoogle Scholar9. NAGASHIMA R, YOSHIDA N, and TERAO N. Sucralfate, a basic aluminum salt of sucrose sulfate. II. Inhibition of peptic hydrolysis as it results from sucrose sulfate interaction with protein substrate, serum albumins. Arzneim Forsch. 1980;30:73-6. MedlineGoogle Scholar10. FORDTRAN J, MORAWSKI S, and RICHARDSON C. In vivo and in vitro evaluation of liquid antacids. N Engl J Med. 1973;288:923-8. CrossrefMedlineGoogle Scholar11. CASPARY W. The influence of glycocholic acid and sucralfate on transmural potential difference of the stomach. In: CASPARY WF, ed. Duodenal Ulcer, Gastric Ulcer: Sucralfate, A New Therapeutic Concept. Baltimore: Urban & Schwarzenberg; 1981:22-7. Google Scholar12. HARRINGTON S, SCHLEGEL J, and CODE C. The protective effect of sucralfate on the gastric mucosa of rats. J Clin Gastroenterol. 1981;3(suppl 2):129-34. MedlineGoogle Scholar13. BLACK R, RHODES J, DAVIES G, GRAVELLE H, and SWEETNAM P. A controlled clinical trial of cholestyramine in the treatment of gastric ulcer. Gastroenterology. 1971;61:821-5. CrossrefMedlineGoogle Scholar14. MESHKINPOUR H, ELASHOFF J, STEWART H, and STURDEVANT R. Effect of cholestyramine on the symptoms of reflux gastritis: a randomized, double blind, crossover study. Gastroenterology. 1977;73:441-3. CrossrefMedlineGoogle Scholar15. MCHARDY G. A multicenter, double-blind trial of sucralfate and placebo in duodenal ulcer. J Clin Gastroenterol. 1981;3(suppl 2): 147-52. MedlineGoogle Scholar16. HOLLANDER D. Efficacy of sucralfate for duodenal ulcers: a multicenter, double-blind trial. J Clin Gastroenterol. 1981;3(suppl 2):153-7. MedlineGoogle Scholar17. MOSHAL M, SPITAELS J, and KHAN F. Sucralfate in the treatment of duodenal ulcers: a double-blind endoscopically controlled trial. 5 Afr Med J. 1980;57:742-4. MedlineGoogle Scholar18. FIXA B and KOMAROVA O. Aluminum sucrose sulphate (sucralfate) in the treatment of peptic ulcer (Double-blind Study). In: CASPARY WF, ed. Duodenal Ulcer, Gastric Ulcer: Sucralfate: A New Therapeutic Concept. Baltimore: Urban & Schwarzenberg; 1981:80-84. Google Scholar19. MARKS I, WRIGHT J, DENYER M, GARISCH J, and LUCKE W. Comparison of sucralfate with Cimetidine in the short-term treatment of chronic peptic ulcers. S Afr Med J 1980;57:567-73. MedlineGoogle Scholar20. MARTIN F, FARLEY A, GAGNON M, and BENSEMANA D. Comparison of the healing capacities of sucralfate and Cimetidine in the short-term treatment of duodenal ulcer: a double-blind randomzied trial. Gastroenterology. 1982;82:401-5. CrossrefMedlineGoogle Scholar21. PETERSON W, STURDEVANT R, and FRANKL H. Healing of duodenal ulcer with an antacid regimen. N Engl J Med. 1977;297:341-5. CrossrefMedlineGoogle Scholar22. ISHIMORI A and ARAKAWA H. A placebo-controlled, double-blind trial using sucralfate for the treatment of peptic ulcer. A multicenter Japanese study. In: CASPARY WF, ed. Duodenal Ulcer, Gastric Ulcer: Sucralfate, A New Therapeutic Concept. Baltimore: Urban & Schwarzenberg; 1981:93-100. Google Scholar23. ORCHARD R and ELLIOT C. A double-blind placebo-controlled study of sucralfate in the treatment of gastric and duodenal ulcer. In CASPARY WF, ed. Duodenal Ulcer, Gastric Ulcer: Sucralfate, A New Therapeutic Concept. Baltimore: Urban & Schwarzenberg; 1981:85-8. Google Scholar24. RHODES J, MAYBERRY J, WILLIAMS R, and LAWRIE B. Clinical trial of sucralfate in the treatment of gastric ulcer. In: CASPARY WF, ed. Duodenal Ulcer, Gastric Ulcer: Sucralfate, A New Therapeutic Concept. Baltimore: Urban & Schwarzenberg; 1981:101-4. Google Scholar25. MOSHAL M, SPITAELS J, and KHAN F. Short- and long-term studies of duodenal ulcer with sucralfate. J Clin Gastroenterol. 1981;3(suppl 2):159-61. MedlineGoogle Scholar26. ISHIMORI A. Safety experience with sucralfate in Japan. J Clin Gastroenterol. 1981;3(suppl 2):169-73. MedlineGoogle Scholar27. FISHER R. Sucralfate: a review of drug tolerance and safety. J Clin Gastroenterol. 1981;3(suppl 2):181-4. MedlineGoogle Scholar28. MCGUIGAN J. A consideration of the adverse effects of Cimetidine. Gastroenterology 1981;80:181-92. CrossrefMedlineGoogle Scholar29. KINOSHITA H, KUMAKI K, NAKANO H, TSUYAMA K, NAGASHIMA R, and OKADA M. Plasma aluminum levels of patients on long term sucralfate therapy, as determined by Zeeman effect flameless atomic absorption spectrometry. Res Commun Clinical Pathol Pharmacol. 1982. (In press). Google Scholar30. KAEHNY W, HEGGS A, and ALFREY A. Gastrointestinal absorption of aluminum from aluminum-containing antacids. N Engl J Med. 1977;296:1389-90. CrossrefMedlineGoogle Scholar31. LACZ J, GROSCHANG A, GEISING D, and BROWNE R. The effect of sucralfate on drug absorption in dogs [Abstract]. Gastroenterology. 1982. (In press). Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CHARLES T. RICHARDSON, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPrevention and treatment of chemotherapy- and radiotherapy-induced oral mucositis: a reviewPERIOPERATIVE PHARMACOLOGYEfficacy of Sucralfate in Refractory Reflux Esophagitis:Results of a Pilot StudyEfficacy of oral sucralfate suspension in prevention and treatment of chemotherapy-induced mucositisPrevention of Duodenal Ulcer RecurrenceWILLIAMSON B. 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BRONZO, M.D. 1 August 1982Volume 97, Issue 2Page: 269-272KeywordsDrugsDuodenal ulcersFood and Drug AdministrationLesionsPepsinsSaltsStomachSucroseUlcers ePublished: 1 December 2008 Issue Published: 1 August 1982 PDF downloadLoading ...