tbuckley/cabot-search huggingface dataset:
WASHINGTON NEWS
Journal: JAMA (1964)

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MISCELLANEA MEDICA
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ocular Manifestations of Nasopharyngeal Tumors
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of intraduodenal infusion of lauric acid and L-tryptophan, alone and combined, on glucoregulatory hormones, gastric emptying and glycaemia in healthy men
Authors: M. Hajishafiee, C. McVeay, K. Lange, J.F. Rehfeld, M. Horowitz, C. Feinle-Bisset
Journal: Metabolism (2022)
Authors’ Reply
Authors: Thibaut Vaulet, Olivier Thaunat, Maarten Naesens
Journal: Journal of the American Society of Nephrology (2021)

We thank Matas et al. for their interest in our algorithm for reclassification of acute kidney transplant rejection.[1][1] We agree that data-driven approaches may add value to the iteratively developed Banff classification.[2][2] Moreover, our approach not only provides an easily accessible system
Camrelizumab plus apatinib as second-line treatment for advanced oesophageal squamous cell carcinoma (CAP 02): a single-arm, open-label, phase 2 trial
Authors: Xiangrui Meng, Tao Wu, Yonggui Hong, Qingxia Fan, Zhonghai Ren, Yanzhen Guo, Xiuli Yang, Pei Shi, Jiamei Yang, Xianzhe Yin, Zhiquan Luo, Jin Xia, Yue Zhou, Mengli Xu, Enjie Liu, Guozhong Jiang, Shenglei Li, Feng Zhao, Chi Ma, Chuanxiang Ma, Zhiguo Hou, Jing Li, Junsheng Wang, Feng Wang
Journal: The Lancet. Gastroenterology & hepatology (2022)
Local Anaesthesia Methods and Results in Abdominal Surgery.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Association between C-reactive protein and polymorphisms in the interleukin-1 gene cluster and coronary artery disease on angiography Peter B. Berger, Martha Nunn, Katherine Stephenson, Gordon W. Duff, George G. Klee, Joseph P. McConnell. Mayo Clinic, Rochester, MN, Interleukin Genetics, Boston, MA
Journal: Journal of the American College of Cardiology (2001)
Postresuscitation care in survivors with acute coronary syndrome complicated by out-of-hospital cardiac arrest Ken Nagao, Katsuo Kanmatsuse, Kazuyoshi Satou, Ikuyoshi Watanabe, Ken Arima, Sumito Oguchi, Satoru Kikuchi, Kimio Kikushima, Sigemasa Tani, Takeo Anazawa, Takashi Miyamoto. Department of Emergency &amp; Critical Care Medicine, Nihon University School of Medicine, Tokyo, Japan, Department of Cardiology, Nihon University School of Medicine, Tokyo, Japan
Journal: Journal of the American College of Cardiology (2001)
Somatic Mutations in Cardiovascular Disease
Authors: J. Brett Heimlich, Alexander G. Bick
Journal: Circulation Research (2022)

Advances in population-scale genomic sequencing have greatly expanded the understanding of the inherited basis of cardiovascular disease (CVD). Reanalysis of these genomic datasets identified an unexpected risk factor for CVD, somatically acquired DNA mutations. In this review, we provide an overview of somatic mutations and their contributions to CVD. We focus on the most common and well-described manifestation, clonal hematopoiesis of indeterminate potential. We also review the currently available data regarding how somatic mutations lead to tissue mosaicism in various forms of CVD, including atrial fibrillation and aortic aneurism associated with Marfan Syndrome. Finally, we highlight future research directions given current knowledge gaps and consider how technological advances will enhance the discovery of somatic mutations in CVD and management of patients with somatic mutations.
Correction to “Sex- and Gender-Based Pharmacological Response to Drugs”
Journal: Pharmacological Reviews (2021)

In the above article [Mauvais-Jarvis F, Berthold HK, Campesi I, Carrero J-J, Dakal S, Franconi F, Gouni-Berthold I, Heiman ML, Kautzky-Willer A, Klein SL, Murphy A, Regitz-Zagrosek V, Reue K, and Rubin JB (2021) Pharmacol Rev , 73: [730-762][1]; DOI: <https://doi.org/10.1124/pharmrev.120.000206> ],
Discordant Metabolic Response on 18F-FDG PET/CT in Synchronous Primary Gastric Lymphoma and Gastric Adenocarcinoma
Authors: Wanting Hao, Yaming Li, Bulin Du, Xuena Li
Journal: Clinical Nuclear Medicine (2022)

An 84-year-old man presented with dysphagia for 20 days. The biopsies of the multiple lesions through gastroscopy revealed gastric diffuse large B-cell lymphoma and gastric adenocarcinoma. Staging 18F-FDG PET/CT showed multiple hypermetabolic lesions in the stomach, abdomen, and pelvis. After 4 courses of chemotherapy, except for the lesion of biopsy-proven gastric adenocarcinoma, other hypermetabolic lesions in stomach and other sites returned to normal on posttherapy 18F-FDG PET/CT. This case indicated that 18F-FDG PET/CT can track differential treatment response of synchronous gastric tumors and guide subsequent therapy.
Reporting of Physicians’ or Investigators’ Choice of Treatment in Oncology Randomized Clinical Trials
Authors: Timothée Olivier, Alyson Haslam, Vinay Prasad
Journal: JAMA Network Open (2022)

This cross-sectional study adhered to Strengthening the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline.Because we used publicly available data, and this was not human subjects research, in accordance with 45 CFR §46.102(f), we did not submit this study to an institutional review board or require informed consent procedures.We sought to determine the total number of published oncology RCTs reporting a physician's (or investigator's) choice, their evolution over time, whether the choice was real (unrestricted) or restricted.We systematically reviewed all reports on RCTs mentioning physician's or investigator's choice (eMethods and eFigure in the Supplement).To be included, articles had to report on RCTs studying anticancer intervention, mentioning "physician's choice" or "investigator's choice" within the title or the abstract.We excluded nononcology reports, phase 1 studies, commentaries, perspectives, and subsequent publication of the same trial.We did not restrict the period of inclusion.The analysis was descriptive, and frequencies were calculated for categorical variables throughout.Statistical analysis was performed using R software version 4.0.4(R Project for Statistical Computing) on November 1, 2021. ResultsOut of the 284 initially identified studies, 92 studies met our inclusion criteria, published between 2007 and 2021 (Table ).Of these 92 oncology RCTs, the most common tumor type studied was breast cancer (22 of 92 RCTs; 23.9%).Over time, there was an increase in the number of published studies mentioning a physician's or investigator's choice in the control group of oncology RCTs (eg, 2 studies in 2007, 3 studies in 2014, and 12 studies in 2021).There were 82 industry-sponsored trials (89.1%) and 10 nonprofit sponsored trials (10.9%).Among the 82 industry-sponsored trials, there
MEDICAL LITERATURE ABSTRACTS
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Trimethoprim in the urinary tract.
Journal: BMJ (1969)

PointersAdverse Reactions to Drugs: Study of over 1,200 hospital patients showed that 10% of those receiving drugs developed reactions to them (p.531).Women and older patients were more commonly affected and so were those with a history of allergy (p.536).The com- monest drugs implicated were corticosteroids, cardiac glycosides, analgesics, antibiotics, and tranquilizers (p.539).Leader at p. 527.Trimethoprim Mixture: In urinary infections sulphamethoxazole and trimethoprim shown to be far superior to sulphonamide alone (p. 541).Combining the two drugs in different proportions gave no obvious benefits (p.545).Leader this page.Letter reporting agranulo- cytosis (p.578).Neuropathy and Diet: Tropical neuropathy in Nigeria was seen where cassava consumption was high and the plasma thiocyanate level raised (p.547).Renal Damage: Reduction in renal mass seen radiographically following acute pyelonephritis (p.550).Asthma: In a double-blind trial of disodium cromoglycate symptoms and peak expiratory flow improved (p. 552).Pill and Coagulation: Women on combined oestrogen-progesterone preparation had signifi- cantly raised levels of factors VII and X, which after change over to progesterone alone fell pro- gressively to normal (p.554).Case Reports: Corticosteroids during preg- nancy (p.556).Late complication of renal transplantation (p.558).
Vascular Stress Signaling in Hypertension
Authors: Stephanie M. Cicalese, Josiane Fernandes da Silva, Fernanda Priviero, R. Clinton Webb, Satoru Eguchi, Rita C. Tostes
Journal: Circulation Research (2021)

Cells respond to stress by activating a variety of defense signaling pathways, including cell survival and cell death pathways. Although cell survival signaling helps the cell to recover from acute insults, cell death or senescence pathways induced by chronic insults can lead to unresolved pathologies. Arterial hypertension results from chronic physiological maladaptation against various stressors represented by abnormal circulating or local neurohormonal factors, mechanical stress, intracellular accumulation of toxic molecules, and dysfunctional organelles. Hypertension and aging share common mechanisms that mediate or prolong chronic cell stress, such as endoplasmic reticulum stress and accumulation of protein aggregates, oxidative stress, metabolic mitochondrial stress, DNA damage, stress-induced senescence, and proinflammatory processes. This review discusses common adaptive signaling mechanisms against these stresses including unfolded protein responses, antioxidant response element signaling, autophagy, mitophagy, and mitochondrial fission/fusion, STING (signaling effector stimulator of interferon genes)-mediated responses, and activation of pattern recognition receptors. The main molecular mechanisms by which the vasculature copes with hypertensive and aging stressors are presented and recent advancements in stress-adaptive signaling mechanisms as well as potential therapeutic targets are discussed.
Freshwater salinisation: a research agenda for a saltier world
Authors: David Cunillera-Montcusí, Meryem Beklioğlu, Miguel Cañedo-Argüelles, Erik Jeppesen, Robert Ptacnik, Cihelio A. Amorim, Shelley E. Arnott, Stella A. Berger, Sandra Brucet, Hilary A. Dugan, Miriam Gerhard, Zsófia Horváth, Silke Langenheder, Jens C. Nejstgaard, Marko Reinikainen, Maren Striebel, Pablo Urrutia-Cordero, Csaba F. Vad, Egor Zadereev, Miguel Matias
Journal: Trends in Ecology & Evolution (2022)

The widespread salinisation of freshwater ecosystems poses a major threat to the biodiversity, functioning, and services that they provide. Human activities promote freshwater salinisation through multiple drivers (e.g., agriculture, resource extraction, urbanisation) that are amplified by climate change. Due to its complexity, we are still far from fully understanding the ecological and evolutionary consequences of freshwater salinisation. Here, we assess current research gaps and present a research agenda to guide future studies. We identified different gaps in taxonomic groups, levels of biological organisation, and geographic regions. We suggest focusing on global- and landscape-scale processes, functional approaches, genetic and molecular levels, and eco-evolutionary dynamics as key future avenues to predict the consequences of freshwater salinisation for ecosystems and human societies.
Government Services
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P062: The Impact of High Fasting Plasma Glucose on Cardiovascular Health at the State-level in the United States
Authors: Kanyin Ong, Ashkan Afshin
Journal: Circulation (2018)

Introduction: High fasting plasma glucose (FPG) is an established risk factor for cardiovascular disease (CVD). However, the impact of FPG on CVD mortality and morbidity at the state-level in the US has not been systematically evaluated. Objective: To quantify the number of CVD deaths and disability adjusted life years (DALYs) attributable to high FPG by age, sex, year and state among US adults from 1990 to 2016. Methods: We used a spatio-temporal Gaussian process regression (ST-GPR) to estimate the mean FPG level by age, sex, year and state. The inputs to the ST-GPR model included data from National Health and Nutrition Examination Survey, state-specific prevalence of obesity, and per-capita lag-distributed income in each state. Using the mean FPG and prevalence of diabetes in each state, we characterized the distribution of the FPG at the state-level. Then, we used the Global Burden of Disease study comparative risk assessment framework to estimate the CVD deaths and DALYs attributable to high FPG. Results: In 2016, there were 180,440 CVD deaths attributable to high FPG in the United States: 77% due to ischemic stroke, 21% due to cerebrovascular disease, and &lt;1% due to peripheral artery disease. Alaska had the lowest attributable death rate for both males and females (66.9 per 100,000 and 55.4 per 100,000, respectively) and West Virginia had the highest attributable death rate for both males and females (227.3 per 100,000 and 186.4 per 100,000, respectively). This is contrasted to DALYS, where Colorado had the lowest attributable DALYS rate for both males and females (1,732 DALYS per 100,000 1,379 DALYS per 100,000, respectively) and West Virginia had the highest attributable DALY rate for both males and females (5,219 DALYS per 100,000 and 3,965 DALYS per 100,000, respectively). (Figure) Conclusions: Our results highlight the need for evidence-based intervention to control FPG to effectively prevent CVD.
Multi-omic analysis in injured humans: Patterns align with outcomes and treatment responses
Authors: Junru Wu, Yoram Vodovotz, Sultan Abdelhamid, Francis X. Guyette, Michael B. Yaffe, Danielle S. Gruen, Anthony Cyr, David O. Okonkwo, Upendra K. Kar, Neha Krishnamoorthi, Robert G. Voinchet, Isabel M. Billiar, Mark H. Yazer, Rami A. Namas, Brian J. Daley, Richard S. Miller, Brian G. Harbrecht, Jeffrey A. Claridge, Herbert A. Phelan, Brian S. Zuckerbraun, Pär I. Johansson, Jakob Stensballe, James H. Morrissey, Russell P. Tracy, Stephen R. Wisniewski, Matthew D. Neal, Jason L. Sperry, Timothy R. Billiar
Journal: Cell Reports Medicine (2021)
Interactions and substrate selectivity within the SctRST complex of the type III secretion system of enteropathogenic <i>Escherichia coli</i>
Authors: Irit Tseytin, Shir Lezerovich, Nofar David, Neta Sal-Man
Journal: Gut Microbes (2021)

Many bacterial pathogens employ a protein complex, termed the type III secretion system (T3SS), to inject bacterial effectors into host cells. These effectors manipulate various cellular processes to promote bacterial growth and survival. The T3SS complex adopts a nano-syringe shape that is assembled across the bacterial membranes, with an extracellular needle extending toward the host cell membrane. The assembly of the T3SS is initiated by the association of three proteins, known as SctR, SctS, and SctT, which create an entry portal to the translocation channel within the bacterial inner membrane. Using the T3SS of enteropathogenic Escherichia coli, we investigated, by mutational and functional analyses, the role of two structural construction sites formed within the SctRST complex and revealed that they are mutation-resistant components that are likely to act as seals preventing leakage of ions and metabolites rather than as substrate gates. In addition, we identified two residues in the SctS protein, Pro23, and Lys54, that are critical for the proper activity of the T3SS. We propose that Pro23 is critical for the physical orientation of the SctS transmembrane domains that create the tip of the SctRST complex and for their positioning with regard to other T3SS substructures. Surprisingly, we found that SctS Lys54, which was previously suggested to mediate the SctS self-oligomerization, is critical for T3SS activity due to its essential role in SctS-SctT hetero-interactions.