tbuckley/cabot-search huggingface dataset:
Endothelial dysfunction and thromboembolism in children, adolescents, and young adults with acute lymphoblastic leukemia
Authors: Liv Andrés-Jensen, Kathrine Grell, Cecilie Utke Rank, Birgitte Klug Albertsen, Ruta Tuckuviene, Rikke Linnemann Nielsen, Line Stensig Lynggaard, Kirsten Brunsvig Jarvis, Petter Quist-Paulsen, Sonata Saulyte Trakymiene, Rūta Semaškevičienė, Kadri Saks, Olafur Gisli Jonsson, Thomas Leth Frandsen, Pär Ingemar Johansson, Kjeld Schmiegelow
Journal: Leukemia (2021)
The Prognostic Significance of Body Mass Index and Metabolic Parameter Variabilities in Predialysis CKD: A Nationwide Observational Cohort Study
Authors: Sehoon Park, Semin Cho, Soojin Lee, Yaerim Kim, Sanghyun Park, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Kyungdo Han, Dong Ki Kim
Journal: Journal of the American Society of Nephrology (2021)

The association between variabilities in body mass index (BMI) or metabolic parameters and prognosis of patients with CKD has rarely been studied.In this retrospective observational study on the basis of South Korea's national health screening database, we identified individuals who received ≥3 health screenings, including those with persistent predialysis CKD (eGFR <60 ml/min per 1.73 m2 or dipstick albuminuria ≥1). The study exposure was variability in BMI or metabolic parameters until baseline assessment, calculated as the variation independent of the mean and stratified into quartiles (with Q4 the highest quartile and Q1 the lowest). We used Cox regression adjusted for various clinical characteristics to analyze risks of all-cause mortality and incident myocardial infarction, stroke, and KRT.The study included 84,636 patients with predialysis CKD. Comparing Q4 versus Q1, higher BMI variability was significantly associated with higher risks of all-cause mortality (hazard ratio [HR], 1.66; 95% confidence interval [95% CI], 1.53 to 1.81), P [for trend] <0.001), KRT (HR, 1.20; 95% CI, 1.09 to 1.33; P<0.001), myocardial infarction (HR, 1.19; 95% CI, 1.05 to 1.36, P=0.003), and stroke (HR, 1.19; 95% CI, 1.07 to 1.33, P=0.01). The results were similar in the subgroups divided according to positive or negative trends in BMI during the exposure assessment period. Variabilities in certain metabolic syndrome components (e.g., fasting blood glucose) also were significantly associated with prognosis of patients with predialysis CKD. Those with a higher number of metabolic syndrome components with high variability had a worse prognosis.Higher variabilities in BMI and certain metabolic syndrome components are significantly associated with a worse prognosis in patients with predialysis CKD.
ホスホリパーゼCΔ1活性の増強により誘発された細胞内Ca2+濃度上昇におけるTRP-Cチャンネルの重要性:冠動脈攣縮におけるその役割
Authors: Murakami Kazuo, Osanai Tomohiro, Ishida Yuji, Suzuki Akiko, Endo Tomohide, Nishizaki Fumie, Sukekawa Takanori, Tomita Hirofumi, Okumura Ken
Journal: Circulation (2013)
Decreased neutralization of the Eta SARS-CoV-2 variant by sera of previously infected and uninfected vaccinated individuals
Authors: Adele Boccuto, Filippo Dragoni, Annalisa Bergna, Carla Della Ventura, Federica Giammarino, Francesco Saladini, Laura Pezzati, Gianguglielmo Zehender, Maurizio Zazzi, Ilaria Vicenti, Alessia Lai
Journal: Journal of Infection (2021)
The circular RNA circINPP4B acts as a sponge of miR-30a to regulate Th17 cell differentiation during progression of experimental autoimmune encephalomyelitis
Authors: Jingjing Han, Wei Zhuang, Wanhua Feng, Fuxing Dong, Fang Hua, Ruiqin Yao, Xuebin Qu
Journal: Cellular and Molecular Immunology (2021)
Combined Impact of Chronic Kidney Disease and Contrast-Induced Nephropathy on Long-term Outcomes in Patients with Acute Myocardial Infarction
Authors: Nakahashi Hidefumi, Kosuge Masami, Kiyokuni Masayoshi, Ebina Toshiaki, Hibi Kiyoshi, Tsukahara Kengo, Iwahashi Noriaki, Maejima Nobuhiko, Akiyama Eiichi, Umemura Satoshi, Kimura Kazuo
Journal: Circulation (2016)
Endoscopic Ultrasonography
Authors: A Das, A Chak
Journal: Endoscopy (2004)

Increasing research related to endoscopic ultrasonography is published every year. A welcome trend towards outcomes-oriented research, evaluating the impact of endoscopic ultrasonography on patient management, is continuing. As experience regarding the safety and efficacy of endosonography-guided fine-needle aspiration in different clinical settings accumulates, this procedure is rapidly becoming a key component of endoscopic ultrasonography. Although promising developments in the fields of guided tissue sampling and image acquisition and analysis are being reported, innovative technical ideas need to be incorporated into the existing endoscopic ultrasound technology to take it to the next level of applications, such as endosurgery.
Impaired CD4 T-cell Response to SARS-CoV-2: Rationale for PD-1 Blockade in Patients with Cancer and COVID-19?
Authors: Bérengère Salomé, Amir Horowitz
Journal: Cancer Discovery (2021)

Abstract Summary: Cancer is a strong risk factor for severe COVID-19 disease. In this issue of Cancer Discovery, Bilich and colleagues demonstrate impaired preexisting and newly generated CD4 T-cell response to SARS-CoV-2 in patients with cancer. See related article by Bilich et al., p. 1982.
Integrative analysis of lung molecular signatures reveals key drivers of systemic sclerosis-associated interstitial lung disease
Authors: Seung Min Jung, Kyung-Su Park, Ki-Jo Kim
Journal: Annals of the Rheumatic Diseases (2021)

Interstitial lung disease is a significant comorbidity and the leading cause of mortality in patients with systemic sclerosis. Transcriptomic data of systemic sclerosis-associated interstitial lung disease (SSc-ILD) were analysed to evaluate the salient molecular and cellular signatures in comparison with those in related pulmonary diseases and to identify the key driver genes and target molecules in the disease module.A transcriptomic dataset of lung tissues from patients with SSc-ILD (n=52), idiopathic pulmonary fibrosis (IPF) (n=549), non-specific interstitial pneumonia (n=49) and pulmonary arterial hypertension (n=81) and from normal healthy controls (n=331) was subjected to filtration of differentially expressed genes, functional enrichment analysis, network-based key driver analysis and kernel-based diffusion scoring. The association of enriched pathways with clinical parameters was evaluated in patients with SSc-ILD.SSc-ILD shared key pathogenic pathways with other fibrosing pulmonary diseases but was distinguishable in some pathological processes. SSc-ILD showed general similarity with IPF in molecular and cellular signatures but stronger signals for myofibroblasts, which in SSc-ILD were in a senescent and apoptosis-resistant state. The p53 signalling pathway was the most enriched signature in lung tissues and lung fibroblasts of SSc-ILD, and was significantly correlated with carbon monoxide diffusing capacity of lung, cellular senescence and apoptosis. EEF2, EFF2K, PHKG2, VCAM1, PRKACB, ITGA4, CDK1, CDK2, FN1 and HDAC1 were key regulators with high diffusion scores in the disease module.Integrative transcriptomic analysis of lung tissues revealed key signatures of fibrosis in SSc-ILD. A network-based Bayesian approach provides deep insights into key regulatory genes and molecular targets applicable to treating SSc-ILD.
Part 6: Defibrillation
Authors: Ian Jacobs, Kjetil Sunde, Charles D. Deakin, Mary Fran Hazinski, Richard E. Kerber, Rudolph W. Koster, Laurie J. Morrison, Jerry P. Nolan, Michael R. Sayre, Mark Angelos, Michael Baubin, M. Fernanda Bellolio, Paul A. Berlin, Richard N. Bradley, Steven M. Bradley, Saul Drajer, Trygve Eftestøl, Chokoh Genka, Erik P. Hess, Ian Jacobs, Richard Kerber, Rudolph W. Koster, Toshihiko Mayumi, Saman Nazarian, Jerry Nolan, Mark Peele, Claudia Ranniger, Giuseppe Ristagno, Comilla Sasson, Shijie Sun
Journal: Circulation (2010)
Microbiota from young mice counteracts selective age-associated behavioral deficits
Authors: Marcus Boehme, Katherine E. Guzzetta, Thomaz F. S. Bastiaanssen, Marcel van de Wouw, Gerard M. Moloney, Andreu Gual-Grau, Simon Spichak, Loreto Olavarría-Ramírez, Patrick Fitzgerald, Enrique Morillas, Nathaniel L. Ritz, Minal Jaggar, Caitlin S. M. Cowan, Fiona Crispie, Francisco Donoso, Evelyn Halitzki, Marta C. Neto, Marzia Sichetti, Anna V. Golubeva, Rachel S. Fitzgerald, Marcus J. Claesson, Paul D. Cotter, Olivia F. O’Leary, Timothy G. Dinan, John F. Cryan
Journal: Nature Aging (2021)
Ptpn2 and KLRG1 regulate the generation and in skin
Authors: Katharina Hochheiser, Florian Wiede, Teagan Wagner, David Freestone, Matthias H Enders, Moshe Olshansky, Brendan Russ, Simone Nussing, Emma Bawden, Asolina Braun, Annabell Bachem, Elise Gressier, Robyn McConville, Simone L Park, Claerwen M Jones, Gayle M Davey, David E Gyorki, David Tscharke, Ian A Parish, Stephen Turner, Marco J Herold, Tony Tiganis, Sammy Bedoui, Thomas Gebhardt
Journal: The Journal of Experimental Medicine (2021)

Tissue-resident memory T cells (TRM cells) are key elements of tissue immunity. Here, we investigated the role of the regulator of T cell receptor and cytokine signaling, Ptpn2, in the formation and function of TRM cells in skin. Ptpn2-deficient CD8+ T cells displayed a marked defect in generating CD69+ CD103+ TRM cells in response to herpes simplex virus type 1 (HSV-1) skin infection. This was accompanied by a reduction in the proportion of KLRG1- memory precursor cells and a transcriptional bias toward terminal differentiation. Of note, forced expression of KLRG1 was sufficient to impede TRM cell formation. Normalizing memory precursor frequencies by transferring equal numbers of KLRG1- cells restored TRM generation, demonstrating that Ptpn2 impacted skin seeding with precursors rather than downstream TRM cell differentiation. Importantly, Ptpn2-deficient TRM cells augmented skin autoimmunity but also afforded superior protection from HSV-1 infection. Our results emphasize that KLRG1 repression is required for optimal TRM cell formation in skin and reveal an important role of Ptpn2 in regulating TRM cell functionality.
Trimethylamine N-oxide induces osteogenic responses in human aortic valve interstitial cells <i>in vitro</i> and aggravates aortic valve lesions in mice
Authors: Jiaying Li, Qingchun Zeng, Zhenyu Xiong, Gaopeng Xian, Zuheng Liu, Qiong Zhan, Wenyan Lai, Lihua Ao, Xianzhong Meng, Hao Ren, Dingli Xu
Journal: Cardiovascular Research (2021)

Abstract Aims Recent studies have shown that the choline-derived metabolite trimethylamine N-oxide (TMAO) is a biomarker that promotes cardiovascular disease through the induction of inflammation and stress. Inflammatory responses and stress are involved in the progression of calcified aortic valve disease (CAVD). Here, we examined whether TMAO induces the osteogenic differentiation of aortic valve interstitial cells (AVICs) through endoplasmic reticulum (ER) and mitochondrial stress pathways in vitro and in vivo. Methods and results Plasma TMAO levels were higher in patients with CAVD (n = 69) than in humans without CAVD (n = 263), as examined by liquid chromatography–tandem mass spectrometry. Western blot and staining probes showed that TMAO-induced an osteogenic response in human AVICs. Moreover, TMAO promoted ER stress, mitochondrial stress, and nuclear factor-κB (NF-κB) activation in vitro. Notably, the TMAO-mediated effects were reversed by the use of ER stress, mitochondrial stress, and NF-κB activation inhibitors and small interfering RNA. Mice treated with supplemental choline in a high-fat diet had markedly increased TMAO levels and aortic valve thicknesses, which were reduced by 3,3-dimethyl-1-butanol (an inhibitor of trimethylamine formation) treatment. Conclusions Choline-derived TMAO promotes osteogenic differentiation through ER and mitochondrial stress pathways in vitro and aortic valve lesions in vivo.
Contributions of the EURO 2020 football championship events to a third wave of SARS-CoV-2 in Scotland, 11 June to 7 July 2021
Authors: Kimberly Marsh, Emily Griffiths, Johanna J. Young, Carrie-Anne Gibb, Jim McMenamin
Journal: Eurosurveillance (2021)

Public Health Scotland used Scottish national contact tracing data to estimate the European football championship (EURO 2020) contributions to a third wave of SARS-CoV-2 infections. From 11 June to 7 July 2021, 2,632 (4%) of 63,874 SARS-CoV-2 cases self-reported attending a EURO 2020 event; 90% were male, of whom 73% were 20-39-year-olds. Most cases attended unofficial gatherings and averaged more contacts than the general population. Targeted guidance on celebrating safely in closed spaces is key.
Poster Discussions
Authors: J. Kraßler, A. Meier-Hellmann, F. Bloos, K. Reinhart, M. Heringlake, J. Sehested, P. B. de Munck, J. H. Rommes, Th. G. M. A. van Deursen, J. Bakker, G. M. Joynt, C. D. Gomersall, T. E. Oh, P. Lahtinen, P. Valta, J. Takala, M. Gama de Abreu, M. Ragaller, M. Quintel, D. M. Albrecht
Journal: Intensive Care Medicine (1996)
Abstract 14187: Blockade of Connexin43 by Carbenoxolone Increases Arrhythmias under Modulation of Mitochondrial KATP Channels
Authors: Masahito Miura, Tetsuya Handoh, Taiki Hasegawa, Riho Ozawa, Chiyohiko Shindoh
Journal: Circulation (2016)

Connexin43 (Cx43) forms gap junction (GJ) channels in the heart and is also present in the inner mitochondrial membrane. The presence of Cx43 is needed for cardioprotection by pharmacological preco...
Diagnosis of Meckel’s diverticulum at the age of 54 by capsule endoscopy
Authors: Ines Trucco, Veronica Guido, José Alvite, Alexandra Duffau, Susana Reyes, Carolina Olano
Journal: Endoscopy (2021)

We report the case of a 54-year-old man who presented with hematochezia and acute anemia (hemoglobin level 5 g/dL). Upper endoscopy and colonoscopy were negative. Capsule endoscopy (Pillcam SB3; Given Imaging, Yoqneam, Israel) performed 7 days after the bleeding episode revealed a double lumen image in the ileum ([Video 1]). No active bleeding was found. A probable diagnosis of Meckel's diverticulum was suggested. Technetium-99 m pertechnetate scintigraphy (Meckel's scan) was negative. The patient was referred for surgery for Meckel's diverticulectomy. The Meckel's diverticulum was in the ileum, 40 cm proximal to the ileocecal valve, and measured 4 cm ([Fig. 1], [Fig. 2]). Histological findings confirmed Meckel's diverticulum.
Nine-Year Follow-up of Patients with Relapsed Follicular Lymphoma after Nonmyeloablative Allogeneic Stem Cell Transplant and Autologous Transplant
Authors: Issa F. Khouri, Denái R. Milton, Alison M. Gulbis, Elias J. Jabbour, Loretta Nastoupil, Celina Ledesma, Paolo Anderlini, Qaiser Bashir, May Daher, Jin S. Im, Swaminathan P. Iyer, David Marin, Rohtesh S. Mehta, Amanda L. Olson, Uday R. Popat, Muzaffar Qazilbash, Neeraj Saini, Felipe Samaniego, Gabriela Rondon, L. Jeffrey Medeiros, Richard E. Champlin
Journal: Clinical Cancer Research (2021)

Abstract Purpose: To compare outcomes between patients with relapsed follicular lymphoma who received a nonmyeloablative allogeneic stem cell transplant (alloSCT) and those who received an autologous transplant (autoSCT). Patients and Methods: We evaluated 194 patients with follicular lymphoma who received an alloSCT (n = 98) or autoSCT (n = 96) at MD Anderson Cancer Center (Houston, TX). The transplant type used was based on donor availability and by Medicare reimbursement guidelines. Patients who received an alloSCT were enrolled in four consecutive trials in which they received fludarabine, cyclophosphamide (or bendamustine), and rituximab conditioning. autoSCT patients received R-BEAM (rituximab, carmustine, etoposide, cytarabine, and melphalan). Results: The median follow-up of survivors was 108 months for the alloSCT group and 102 months for the autoSCT group. Overall survival was significantly better for patients who received an alloSCT compared with those who received an autoSCT (62% vs. 46%; P = 0.048). Similarly, progression-free survival rates were 52% in patients who received an alloSCT and 31% in those who received an autoSCT (P &amp;lt; 0.001), and the 8-year relapse rates were 11% and 43%, respectively (P &amp;lt; 0.0001). Only three patients in the alloSCT group relapsed beyond 3.5 years. In the alloSCT group, the rates for grade 2 to 4 acute graft-versus-host disease (GVHD), grade 3 to 4 acute GVHD, and extensive chronic GVHD were 22%, 9%, and 38%, respectively. In the autoSCT group, the 8-year incidence of secondary myelodysplasia was 11%. Nonrelapse mortality was similar between the two groups (15% vs. 11% at 8 years; P = 0.27). Conclusions: This study shows that alloSCT is curative and confers superior survival compared with autoSCT in patients with follicular lymphoma.
Bioinspired urease-powered micromotor as an active oral drug delivery carrier in stomach
Authors: Hyunsik Choi, Sang Hoon Jeong, Tae Yeon Kim, Jeeyoon Yi, Sei Kwang Hahn
Journal: Bioactive Materials (2021)

Self-propelling micro- and nano-motors (MNMs) have been extensively investigated as an emerging oral drug delivery carrier for gastrointestinal (GI) tract diseases. However, the propulsion of current MNMs reported so far is mostly based on the redox reaction of metals (such as Zn and Mg) with severe propulsion gas generation, remaining non-degradable residue in the GI tract. Here, we develop a bioinspired enzyme-powered biopolymer micromotor mimicking the mucin penetrating behavior of Helicobacter pylori in the stomach. It converts urea to ammonia and the subsequent increase of pH induces local gel-sol transition of the mucin layer facilitating the penetration into the stomach tissue layer. The successful fabrication of micromotors is confirmed by high-resolution transmission electron microscopy, electron energy loss spectroscopy, dynamic light scattering analysis, zeta-potential analysis. In acidic condition, the immobilized urease can efficiently converted urea to ammonia, comparable with that of neutral condition because of the increase of surrounding pH during propulsion. After administration into the stomach, the micromotors show enhanced penetration and prolonged retention in the stomach for 24 h. Furthermore, histological analysis shows that the micromotors are cleared within 3 days without causing any toxicity in the GI tract. The enhanced penetration and retention of the micromotors as an active oral delivery carrier in the stomach would be successfully harnessed for the treatment of various GI tract diseases.
Terminal decline in objective and self-reported measures of motor function before death: 10 year follow-up of Whitehall II cohort study
Authors: Benjamin Landré, Aurore Fayosse, Céline Ben Hassen, Marcos D Machado-Fragua, Julien Dumurgier, Mika Kivimaki, Séverine Sabia, Archana Singh-Manoux
Journal: BMJ (2021)

Abstract Objectives To examine multiple objective and self-reported measures of motor function for their associations with mortality. Design Prospective cohort study. Setting UK based Whitehall II cohort study, which recruited participants aged 35-55 years in 1985-88; motor function component was added at the 2007-09 wave. Participants 6194 participants with motor function measures in 2007-09 (mean age 65.6, SD 5.9), 2012-13, and 2015-16. Main outcome measures All cause mortality between 2007 and 2019 in relation to objective measures (walking speed, grip strength, and timed chair rises) and self-reported measures (physical component summary score of the SF-36 and limitations in basic and instrumental activities of daily living (ADL)) of motor function. Results One sex specific standard deviation poorer motor function in 2007-09 (cases/total, 610/5645) was associated with an increased mortality risk of 22% (95% confidence interval 12% to 33%) for walking speed, 15% (6% to 25%) for grip strength, 14% (7% to 23%) for timed chair rises, and 17% (8% to 26%) for physical component summary score over a mean 10.6 year follow-up. Having basic/instrumental ADL limitations was associated with a 30% (7% to 58%) increased mortality risk. These associations were progressively stronger when measures were drawn from 2012-13 (mean follow-up 6.8 years) and 2015-16 (mean follow-up 3.7 years). Analysis of trajectories showed poorer motor function in decedents (n=484) than survivors (n=6194) up to 10 years before death for timed chair rises (standardised difference 0.35, 95% confidence interval 0.12 to 0.59; equivalent to a 1.2 (men) and 1.3 (women) second difference), nine years for walking speed (0.21, 0.05 to 0.36; 5.5 (men) and 5.3 (women) cm/s difference), six years for grip strength (0.10, 0.01 to 0.20; 0.9 (men) and 0.6 (women) kg difference), seven years for physical component summary score (0.15, 0.05 to 0.25; 1.2 (men) and 1.6 (women) score difference), and four years for basic/instrumental ADL limitations (prevalence difference 2%, 0% to 4%). These differences increased in the period leading to death for timed chair rises, physical component summary score, and ADL limitations. Conclusion Motor function in early old age has a robust association with mortality, with evidence of terminal decline emerging early in measures of overall motor function (timed chair rises and physical component summary score) and late in basic/instrumental ADL limitations.
Synaptic correlates of associative fear memory in the lateral amygdala
Authors: Dong Il Choi, Jooyoung Kim, Hoonwon Lee, Ji-il Kim, Yongmin Sung, Ja Eun Choi, S. Jayakumar Venkat, Pojeong Park, Hyunsu Jung, Bong-Kiun Kaang
Journal: Neuron (2021)
Diabetes mellitus and hearing loss: A review
Authors: Dorit Samocha-Bonet, Buffy Wu, David K. Ryugo
Journal: Ageing Research Reviews (2021)

Diabetes (type 2) and sensorineural hearing loss are common health problems manifested with ageing. While both type 1 and type 2 diabetes have been associated with hearing loss, a causal link has been difficult to establish. Individuals with diabetes have twice the incidence of hearing loss compared to those without diabetes and those with prediabetes have a 30% higher rate of hearing loss. Whether hearing loss is associated with diabetes independent of glycemic control remains to be determined. Hearing loss has its own set of risk factors and shares others with diabetes. This review will summarize the complex relationship between diabetes and sensorineural hearing loss.
Outcomes of Patients Denied Extracorporeal Membrane Oxygenation during the COVID-19 Pandemic in Greater Paris, France
Authors: David Levy, Guillaume Lebreton, Marc Pineton de Chambrun, Guillaume Hékimian, Juliette Chommeloux, Nicolas Bréchot, Charles-Edouard Luyt, Pascal Leprince, Alain Combes, Matthieu Schmidt
Journal: American Journal of Respiratory and Critical Care Medicine (2021)