tbuckley/cabot-search huggingface dataset:
The m6A RNA methylation regulates oncogenic signaling pathways driving cell malignant transformation and carcinogenesis
Authors: Mohammad Burhan Uddin, Zhishan Wang, Chengfeng Yang
Journal: Molecular Cancer (2021)

Abstract The m 6 A RNA methylation is the most prevalent internal modification in mammalian mRNAs which plays critical biological roles by regulating vital cellular processes. Dysregulations of the m 6 A modification due to aberrant expression of its regulatory proteins are frequently observed in many pathological conditions, particularly in cancer. Normal cells undergo malignant transformation via activation or modulation of different oncogenic signaling pathways through complex mechanisms. Accumulating evidence showing regulation of oncogenic signaling pathways at the epitranscriptomic level has added an extra layer of the complexity. In particular, recent studies demonstrated that, in many types of cancers various oncogenic signaling pathways are modulated by the m 6 A modification in the target mRNAs as well as noncoding RNA transcripts. m 6 A modifications in these RNA molecules control their fate and metabolism by regulating their stability, translation or subcellular localizations. In this review we discussed recent exciting studies on oncogenic signaling pathways that are modulated by the m 6 A RNA modification and/or their regulators in cancer and provided perspectives for further studies. The regulation of oncogenic signaling pathways by the m 6 A modification and its regulators also render them as potential druggable targets for the treatment of cancer.
Myocardial and cerebral hemodynamics during tachyarrhythmia-induced hypotension in the rat.
Authors: AHagendorff, CDettmers, PDanos, LPizzulli, HOmran, MManz, AHartmann, BLüderitz
Journal: Circulation (1994)

BACKGROUNDThe different vulnerabilities of heart and brain to hypotension and hypoxia have been discussed. Hemorrhagic or cardiogenic hypotension appears to cause greater cerebral lesions than drug-induced hypotension. The present model was established to evaluate myocardial blood flow (MBF) and function of the heart and cerebral blood flow (CBF) during tachyarrhythmias and to characterize the capacity of blood flow regulation in the heart and brain during tachycardia-induced borderline hypotension.METHODS AND RESULTSMBF and CBF were determined with radiolabeled microspheres. Coronary and central venous oxygen tensions were measured to estimate myocardial and cerebral oxygen consumption (MVO2 and CVO2). Measurements were performed in 62 Sprague-Dawley rats during sinus rhythm and high-rate left ventricular pacing and after hemorrhage. In control rats, MBF and CBF were 5.08 +/- 1.07 and 1.09 +/- 0.29 mL.g-1.min-1. MBF increased (7.21 +/- 1.98 mL.g-1.min-1, P < .05), whereas CBF decreased (0.99 +/- 0.29 mL....
Plummer-Vinson Syndrome: Epidemiological Characteristics and Endoscopic Dilation Outcomes
Authors: S Bradai, M Mahmoudi, A Khsiba, M Medhioub, A Ben Mohamed, l Hamzaoui, MM Azouz
Journal: Endoscopy (2021)

Aims Plummer-Vincent syndrome (PVS) is a rare condition, defined by the association of dysphagia, iron deficiency anemia and a post-cricoid esophageal web. It is considered as a precancerous condition. Although correcting the anemia may improve these symptoms, endoscopic dilation of the esophageal web is sometimes necessary. The goal of our work is to study the clinical, endoscopic, therapeutic and evolutionary characteristics of this condition.
New aspects in ultrasound-guided compression repair of postcatheterization femoral artery injuries.
Authors: FSchaub, WTheiss, MHeinz, MZagel, ASchömig
Journal: Circulation (1994)

BACKGROUNDThis study was undertaken to expand the understanding of ultrasound-guided compression repair (UGCR) of postcatheterization femoral artery injuries.METHODS AND RESULTSIn a series of 62 patients with pseudoaneurysms (n = 53) or arteriovenous (AV) fistulas (n = 9), UGCR was performed as a nonsurgical method in the treatment of postcatheterization femoral artery injuries. When the communicating channel could be visualized (43 cases), pressure was focused on it; otherwise (10 cases) the extraluminal cavity itself was compressed. In 45 cases, the elimination of flow in the pseudoaneurysm and/or the communicating channel could be achieved only with simultaneous temporary complete occlusion of the femoral artery. UGCR was successfully performed in 25 of 27 cases of false aneurysms (93%) in patients without anticoagulation and in 14 of 26 patients (54%) on anticoagulants. Three of 9 AV fistulas could be repaired by this method. No apparent correlation could be found between the therapeutic success and t...
Physical Medicine and Rehabilitation
Authors: Barry S. Smith
Journal: JAMA (1989)

CONTEMPO last reviewed the specialty of physical medicine and rehabilitation (physiatry) in October 1986.<sup>1</sup>During that seemingly brief span of time, changes in the field have been remarkable. It has expanded in numbers, in breadth, and in scientific application. The most obvious track of the numerical growth in physiatry can be seen through the rapid increase in residency positions.<sup>2</sup>In the 1985-1986 academic year, there were 819 residency positions available; 795 of these (97%) were filled. For the 1988-1989 academic year, there were 1005 positions offered, and 984 (98%) were filled. This is an increase of 23% in only 3 years. Similarly, there has been an increasing percentage of American medical graduates filling these positions. In 1981, only 51% of residents were graduates of American medical schools. For the 1988-1989 academic year, 91% are American graduates. The specialty is composed largely of young physicians. In 1988, Gonzalez et
Redistribution of regional and organ blood volume and effect on cardiac function in relation to upright exercise intensity in healthy human subjects.
Authors: S DFlamm, JTaki, RMoore, S FLewis, FKeech, FMaltais, MAhmad, RCallahan, SDragotakes, NAlpert
Journal: Circulation (1990)

To determine the effect of relative exercise intensity on organ blood volume and its relation to cardiac function, changes in relative blood volume and cardiac function were monitored with radionuclide techniques in 14 healthy volunteers. After labeling the subject's red cells with technetium 99m, we acquired data at rest, zero-load cycling, and at 50%, 75%, and 100% of maximal oxygen uptake. From rest to zero-load cycling, leg blood volume decreased 32 +/- 2% (mean +/- SEM), whereas relative end-diastolic blood volume increased 9.6 +/- 1.2%, and lung blood volume increased 18 +/- 2%, suggesting that the lungs may act as a blood volume buffer during periods of acutely increased venous return. With relative increasing exercise, leg blood volume stabilized, and then the blood volume in the abdominal organs decreased, further augmenting cardiopulmonary blood volume; leg blood volume and abdominal blood volume decreased by 23 +/- 2% and 19 +/- 2% from baseline, respectively, whereas thoracic blood volume incr...
99mTc-pyrophosphate imaging in patients with acute myocardial infarction: comparison of planar imaging with single-photon tomography with and without blood pool overlay.
Authors: J RCorbett, MLewis, J TWillerson, P HNicod, R LHuxley, TSimon, R ERude, EHenderson, RParkey, J SRellas
Journal: Circulation (1984)

To test the hypothesis that single-photon emission computed tomography (SPECT) of 99mTc-pyrophosphate (99mTc-PPi) with and without the overlay of tomographic blood pool scintigrams might detect small infarcts not identified by planar imaging, 52 patients were studied 3.2 +/- 2.0(SD) days after hospital admission for suspected acute myocardial infarction. Patients were chosen prospectively for tomographic study primarily, but not exclusively, because planar four-view imaging with 99mTc-PPi was either negative or equivocal. SPECT was performed with a commercial rotating detector system immediately after planar imaging on one occasion. Corresponding 99mTc-PPi and blood pool sections were mapped into opposite halves of a bichromic color table and displayed as an overlay. Planar images, SPECT and SPECT with blood pool overlay were interpreted separately and in random order without knowledge of clinical data. Seventeen patients had transmural infarcts (four anterior, 13 inferior), 19 had nontransmural infarcts,...
Ductus arteriosus. Advanced differentiation of smooth muscle cells demonstrated by myosin heavy chain isoform expression in rabbits.
Authors: H SKim, MAikawa, KKimura, MKuro-o, KNakahara, TSuzuki, HKatoh, EOkamoto, YYazaki, RNagai
Journal: Circulation (1993)

BACKGROUNDThe closure of the ductus arteriosus (DA) is one of the most striking cardiovascular events that occur at birth. It has been attributed to oxygenation and intrinsic prostaglandins. However, selective constriction of DA suggests the presence of highly specialized contractile mechanisms in DA. We previously reported that smooth muscle myosin heavy chain isoforms, SM1 and SM2, are molecular markers for smooth muscle differentiation because of their unique expression pattern during vascular development. SM1 and SM2 are generated from a single gene through developmentally regulated alternative RNA splicing; SM1 is expressed in almost all stages of differentiation of the vascular smooth muscles, but SM2 is found only after birth.METHODS AND RESULTSImmunohistochemistry was performed to study the expression of the different types of myosin heavy chain isoforms in DA of fetal and neonatal rabbits. Electron microscopic examinations were also carried out to demonstrate ultrastructural characteristics of du...
Response to Comment on Burrows et al. Declining Rates of Hospitalization for Selected Cardiovascular Disease Conditions Among Adults Aged ≥35 Years With Diagnosed Diabetes, U.S., 1998–2014. Diabetes Care 2018;41:293–302
Authors: Nilka Ríos Burrows, YanFeng Li, Linda S. Geiss, Edward W. Gregg
Journal: Diabetes Care (2018)

As noted by de Miguel-Yanes et al. (1), we reported a decline in hospitalization rates from 1998 to 2014 for several cardiovascular disease (CVD) conditions in the U.S. population with diabetes (2). Similar to their report on cardiovascular events in people with diabetes in Spain (3), we found that during the study period hospitalization rates for acute coronary …
Suppression of calcific fibrous-fatty plaque formation in rabbits by agents not affecting elevated serum cholesterol levels. The effect of thiophene compounds.
Authors: C TChan, HWells, D MKramsch
Journal: Circulation Research (1978)

We tested the suppressive effect of antihypercalcemic-hyperphosphatemic agents on atherogenesis. We studied five groups of rabbits for 8 weeks, one control group and four groups on a fibrogenic atherogenic diet. One group received the atherogenic diet alone, and the remaining three atherogenic groups were treated simultaneously with 2-thiophenecarboxylic acid (ThCA), 5-methyl-2-thiophenecarboxylic acid (5-CH3-ThCA), and 5-bromo-2-thiophenecarboxaldehyde (5-Br-ThCA). Rabbits receiving the atherogenic diet alone developed: (1) elevations of serum cholesterol, calcium, and phosphorus; (2) massive fibrous-fatty aortic plaques with excessive accumulation of aortic collagen, elastin, and lipids; (3) marked deposition of calcium and phosphorus in both aortic tissue and elastin; and (4) severe lipid infiltration of the liver. Treatment with all three drugs normalized the elevated serum calcium but not the cholesterol levels, and effectively inhibited all aspects of the atherosclerotic process as determined morpho...
Telomere Shortening, TP53 Mutations and Deletions in Chronic Lymphocytic Leukemia Result in Increased Chromosomal Instability and Breakpoint Clustering in Heterochromatic Regions
Authors: Gudrun Göhring, Kathrin Thomay, Caroline Fedder, Winfried Hofmann, Hans Heinrich Kreipe, Brigitte Schlegelberger
Journal: Blood (2016)
Angled tip ERCP Guidewires Appear To Be Advantageous for Intrahepatic Stenosis in Comparison to Straight tip Guidewires: Results from a Randomized Multicentre Study
Authors: J Hausmann, F Lefa, N Filmann, A Eickhoff, M Tantau, J Albert
Journal: Endoscopy (2021)

Aims Endoscopic retrograde cholangiopancreatography (ERCP) is the mainstay for treating many bilio-pancreatic diseases and highly effective guidewires are essential for treatment success. However, performance of different types of guidewires remains ambiguous in most indications.
Dual action of FRC8653, a novel dihydropyridine derivative, on the Ba2+ current recorded from the rabbit basilar artery.
Authors: MOike, YInoue, KKitamura, HKuriyama
Journal: Circulation Research (1990)

Actions of FRC8653 on the macroscopic and unitary Ba2+ currents were studied using the rabbit basilar artery. Application of (+/-)-FRC8653 (less than 1 microM) increased the amplitude of the inward current when depolarization pulses more negative than -10 mV were applied but inhibited it when depolarization was more positive than 0 mV (in each case from a holding potential of -80 mV). At a holding potential of -40 mV, (+/-)-FRC8653 (greater than 0.1 nM) consistently inhibited the inward current. (-)-FRC8653 (greater than 1 nM) inhibited the amplitude of the inward current evoked by a depolarizing pulse more positive than -10 mV (the holding potential being -80 mV). At the holding potential of -80 mV, but not at -40 mV, (+)-FRC8653 (1 microM) enhanced the current amplitude evoked by a depolarizing pulse more negative than -10 mV but inhibited the current evoked by a pulse more positive than 0 mV. (+/-)-FRC8653 shifted the voltage-dependent inhibition curves to the left, and the slope of the curve became st...
Shall The Journal be Removed to Washington?
Authors: J. H. Lyon
Journal: JAMA (1891)

<h3>To the Editor:</h3> —The pride of the American physician consists in his success, his success in his advantages, and his advantages of readingThe Journalat an early date will be greater if allowed to remain in Chicago than if taken to Washington. I mean the M.D's of the West. Roslyn, Washington, Jan. 22, 1891.
Re-entry due to manifest and concealed. His bundle ectopic systoles. Report of a case.
Authors: NEl-Sherif, BBefeler, JAranda, ACastellanos, RLazzara
Journal: Circulation (1976)

Concealed (C) His bundle ectopic systoles (H') have been shown in man to give rise to first and second degree atrioventricular (A-V) block and to simulate nonconducted atrial premature beats (P'). This report outlines a hitherto undescribed electrophysiologic consequence of H' in a 69-year-old man with arteriosclerotic heart disease and a Wenckebach type second degree A-V block in the His-Purkinje system. During a His bundle study, H' were shown to conduct either to the atria and ventricles with varying relationships to P' and QRS, or to conduct only to the atria, simulating nonconducted P' or atrial fusion beats. Both types of H' could initiate a re-entrant arrhythmia during retrograde conduction. Of particular interest are late coupled H' that failed to conduct to the ventricles and also failed to activate the atria because of prior capture by the sinus impulse (CH'). These CH' could also initiate re-entry by conducting retrogradely to engage the subatrial re-entry circuit. Evidence is presented to sugg...
Cardiac morbidity and mortality due to Chagas' disease: prospective electrocardiographic study of a Brazilian community.
Authors: J HMaguire, RHoff, ISherlock, A CGuimarães, A CSleigh, N BRamos, K EMott, T HWeller
Journal: Circulation (1987)

The evolution of Chagas' cardiomyopathy is poorly understood. We therefore examined the development of cardiac lesions in a rural Brazilian community for a period of 7 years. Initially, 42% of 1017 residents were seropositive for infection with Trypanosoma cruzi. Age-specific infection rates indicated that most had become infected before the age of 20 years. On follow-up, it appeared that those persons who developed cardiac lesions did so soon after infection, since the incidence of right bundle branch block and other ventricular conduction defects (VCDs) was also highest before age 20 years. The progressive nature of these lesions was demonstrated by frequent development of additional electrocardiographic abnormalities and high mortality among infected adults with VCDs. In contrast, mortality was low and approximately the same for seropositive and seronegative adults under 60 years who had normal electrocardiograms. Electrocardiography during the early asymptomatic stage of infection was able to distingu...
Importance of sympathetic innervation in the positive inotropic effects of bradykinin and ramiprilat.
Authors: R DMinshall, V PYelamanchi, ADjokovic, D JMiletich, E GErdös, S FRabito, S MVogel
Journal: Circulation Research (1994)

Isolated rat left atria or right ventricular strips were electrically stimulated at a constant frequency. The amplitude of twitch contractions, thus elicited, rose as a function of stimulation intensity because of increases in the evoked release of sympathetic catecholamines. Bradykinin had no effect on contractile force in preparations paced at a minimal intensity (threshold). By contrast, bradykinin (1 nmol/L to 1 mumol/L) markedly increased twitch contractile force when the preparations were paced at a high intensity (two to three times threshold). The EC50 for the positive inotropic action of bradykinin averaged 42 nmol/L. Ramiprilat (1 mumol/L), an angiotensin I-converting enzyme/kinase II inhibitor, shifted the EC50 for bradykinin to approximately 2 nmol/L. Ramiprilat (1 mumol/L) per se also produced a modest positive inotropic effect. The effects of bradykinin and/or ramiprilate were inhibited by HOE 140 (300 nmol/L), a bradykinin B2-receptor antagonist. Propranolol (1 mumol/L), a beta-adrenoceptor...
Effects of calcium channel blockade on renal vascular resistance responses to changes in perfusion pressure and angiotensin-converting enzyme inhibition in dogs.
Authors: L GNavar, W JChampion, C EThomas
Journal: Circulation Research (1986)

We conducted these experiments to evaluate the selectivity of calcium channel blockade on the renal autoregulatory mechanism and on angiotensin II-mediated renal vasoconstriction. Experiments were performed in anesthetized dogs in which renal arterial pressure, renal blood flow, and glomerular filtration rate were measured at normal and reduced renal arterial pressure. At control arterial pressures, renal arterial infusions of verapamil increased renal blood flow and glomerular filtration rate significantly. The decreases in renal vascular resistance elicited with verapamil (n = 13) and nifedipine (n = 4) occurred only at renal arterial pressure levels within the normal autoregulatory range. Renal blood flow autoregulatory efficiency was markedly attenuated, and the pressure-flow relationship obtained during calcium channel blockade approached that of a passive system. Systemic infusions of an angiotensin-converting enzyme inhibitor (captopril) during continued verapamil infusion caused further vasodilati...
Intubation With Video Laryngoscopy vs Direct Laryngoscopy
Authors: Ne-Hooi Will Loh, Joanna Tan
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The role of adenosine in prolonged vasodilation following flow-restricted exercise of canine skeletal muscle.
Authors: F LBelloni, R DPhair, H VSparks
Journal: Circulation Research (1979)

A period of prolonged vasodilation follows flow-restricted exercise of skeletal muscle. We tested the hypothesis that adenosine participates in mediating this vascular response. Vascularly isolated, anterior calf muscles of anesthetized dogs were stimulated to contract at a rate of 4 twitches/sec. Blood flow was held constant at 12.5 +/- 1.3 ml/min per 100 g which was about 14% of the expected free flow for this exercise level. Skeletal muscle tissue adenosine was measured with the an enzymatic, spectophotometric assay of trichloroacetic acid extracts of congruent to 50 mg biopsy samples. Tissue adenosine rose from 2.30 +/- 0.90 nmol/g in resting muscle to 22.5 +/- 5.8 nmol/g by the end of the 22-minute exercise. Following exercise, tissue adenosine fell toward its baseline value with a time course very similar to the early portion of the return of skeletal muscle vascular resistance to its control level. Thus, skeletal muscle adenosine content (1) increases to a sufficient magnitude and (2) falls with an...
99O_PR KRYSTAL-1: Activity and preliminary pharmacodynamic (PD) analysis of adagrasib (MRTX849) in patients (Pts) with advanced non–small cell lung cancer (NSCLC) harboring KRASG12C mutation
Authors: G.J. Riely, S-H.I. Ou, I. Rybkin, A. Spira, K. Papadopoulos, J.K. Sabari, M. Johnson, R.S. Heist, L. Bazhenova, M. Barve, J.M. Pacheco, K. Velastegui, C. Cilliers, P. Olson, J.G. Christensen, T. Kheoh, R.C. Chao, P.A. Jänne
Journal: Journal of Thoracic Oncology (2021)
Effects of coronary artery reperfusion on myocardial infarct size and survival in conscious dogs.
Authors: K LBaughman, P RMaroko, S FVatner
Journal: Circulation (1981)

The effects of coronary artery reperfusion at 1 and 3 hours after coronary artery occlusion were examined on myocardial infarct size and survival in conscious dogs. Left circumflex coronary artery occlusion was induced by inflating an hydraulic occluder and confirmed thereafter by measuring the absence of coronary blood flow. Of the 77 dogs that underwent coronary artery occlusion, 18 died within 1 hour. Of the 59 remaining dogs, permanent coronary artery occlusion was carried out in 31 dogs, 12 underwent reperfusion after 1 hour and 16 underwent reperfusion after 3 hours. Survival at 1 week was enhanced significantly (p < 0.01) by reperfusion carried out at either 1 or 3 hours; only 29% of dogs with permanent coronary artery occlusion survived, whereas 83% and 75% of dogs survived 1 week with reperfusion at 1 hour and 3 hours, respectively. Average infarct size at 1 week was smaller in dogs with reperfusion (NS). The inability to reach statistical significance was most likely the result of two factors: (...