Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia
Authors: Stefanie Kreutmair, Susanne Unger, Nicolás Gonzalo Núñez, Florian Ingelfinger, Chiara Alberti, Donatella De Feo, Sinduya Krishnarajah, Manuel Kauffmann, Ekaterina Friebel, Sepideh Babaei, Benjamin Gaborit, Mirjam Lutz, Nicole Puertas Jurado, Nisar P. Malek, Siri Goepel, Peter Rosenberger, Helene A. Häberle, Ikram Ayoub, Sally Al-Hajj, Jakob Nilsson, Manfred Claassen, Roland Liblau, Guillaume Martin-Blondel, Michael Bitzer, Antoine Roquilly, Burkhard Becher
Journal: Immunity (2022)

(Immunity 54, 1578–1593.e1–e5; July 13, 2021) In our original article, the FlowSOM-generated CD3+CD56+CD4−CD8− T cell cluster was named NKT cells. CD3+CD56+ cells do not exclusively describe NKT cells, but rather a heterogeneous collection of unconventional T cells. As we had not included iNKT-specific CD1d tetramers loaded with α-galactosylceramide in our panels, to be more precise, we corrected the term NKT cells with CD56+ T cells throughout the text and in the listed figures, as well as Tables S1, S3, and S4 and the graphical abstract. This error does not affect the overall conclusions of the paper. Additionally, to more appropriately reflect this change, reference Zhang et al., 2020a has been replaced with Notarbartolo et al., 2021Notarbartolo S. Ranzani V. Bandera A. Gruarin P. Bevilacqua V. Putignano A.R. Gobbini A. Galeota E. Manara C. Bombaci M. et al.Integrated longitudinal immunophenotypic, transcriptional and repertoire analyses delineate immune responses in COVID-19 patients.Sci Immunol. 2021; 6: eabg5021Crossref PubMed Scopus (21) Google Scholar.The authors apologize for any confusion caused.Figure 2BShared T cell features between severe pathogen-induced RSs highlight the emergence of hyperinflammatory and exhausted subsets in COVID-19s (corrected)View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure 5Distinct signatures of COVID-19s are exclusive to the lymphocyte compartment (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure 5Distinct signatures of COVID-19s are exclusive to the lymphocyte compartment (corrected)View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure 6HLA profile links COVID-19 immunopathology to impaired virus recognition (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure 6HLA profile links COVID-19 immunopathology to impaired virus recognition (corrected)View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure 7BACE2 expression in a CD4+ T cell subset increases after ex vivo stimulation (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure 7BACE2 expression in a CD4+ T cell subset increases after ex vivo stimulation (corrected)View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure S2(original)View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure S2(corrected)View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure S7(original)View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure S7(corrected)View Large Image Figure ViewerDownload Hi-res image Download (PPT) Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumoniaKreutmair et al.ImmunityMay 9, 2021In BriefThe pathogen-specific immune alterations in severe COVID-19 remain unknown. Using longitudinal, high-dimensional, single-cell spectral cytometry and algorithm-guided comparison of COVID-19 versus non-SARS-CoV-2-pneumonia patient samples, Kreutmair et al. identify T and NK cell immune signatures specific to SARS-CoV-2. They furthermore reveal CD56+T cell frequency as a predictive biomarker for COVID-19 outcome prediction and link impaired virus recognition to HLA genetics. Full-Text PDF Open Access