tbuckley/cabot-search huggingface dataset:
TCT-151 Five-Year Clinical Outcome of the Biodegradable Polymer Ultrathin Strut Sirolimus-Eluting Stent Compared With the Biodegradable Polymer Biolimus-Eluting Stent in Patients Treated With Percutaneous Coronary Intervention: From the SORT OUT VII Trial
Authors: Kirstine Hansen, Lisette Okkels Jensen, Michael Maeng, Martin Kirk Christensen, Johnny Kahlert, Lars Jakobsen, Anders Junker, Phillip Freeman, Manijeh Noori, Julia Ellert, Bent Raungaard, Christian Terkelsen, Henrik Hansen, Evald Christiansen
Journal: Journal of the American College of Cardiology (2021)
Vision redemption: Self-reporting AIEgens for combined treatment of bacterial keratitis
Authors: Chen Peng, Wenjie Sun, Chengcheng Zhou, Sujing Qiang, Meijuan Jiang, Jacky W.Y. Lam, Zheng Zhao, Ryan T.K. Kwok, Wenting Cai, Ben Zhong Tang
Journal: Biomaterials (2021)
Efficacy of antibiotic short course for bloodstream infections in acute myeloid leukemia patients with febrile neutropenia: A retrospective comparative study
Authors: Agathe Metais, Jose Miguel Torregrosa Diaz, Maria Pilar Gallego Hernanz, Maxime Pichon, Deborah Desmier, France Roblot, Blandine Rammaert
Journal: Journal of Infection (2021)
Estimating dynamic vascular perfusion based on Er-based lanthanide nanoprobes with enhanced down-conversion emission beyond 1500 nm
Authors: Qian Jia, Zheng Li, Mingli Bai, Haohao Yan, Ruili Zhang, Yu Ji, Yanbin Feng, Zuo Yang, Zhongliang Wang, Jianxiong Li
Journal: Theranostics (2021)

Peripheral artery disease (PAD) is a common, yet serious, circulatory condition that can increase the risk of amputation, heart attack or stroke. Accurate identification of PAD and dynamic monitoring of the treatment efficacy of PAD in real time are crucial for optimizing therapeutic outcomes. However, current imaging techniques do not enable these requirements.
The impact of school opening model on SARS-CoV-2 community incidence and mortality
Authors: Zeynep Ertem, Elissa M. Schechter-Perkins, Emily Oster, Polly van den Berg, Isabella Epshtein, Nathorn Chaiyakunapruk, Fernando A. Wilson, Eli Perencevich, Warren B. P. Pettey, Westyn Branch-Elliman, Richard E. Nelson
Journal: Nature Medicine (2021)

The role that traditional and hybrid in-person schooling modes contribute to the community incidence of SARS-CoV-2 infections relative to fully remote schooling is unknown. We conducted an event study using a retrospective nationwide cohort evaluating the effect of school mode on SARS-CoV-2 cases during the 12 weeks after school opening (July–September 2020, before the Delta variant was predominant), stratified by US Census region. After controlling for case rate trends before school start, state-level mitigation measures and community activity level, SARS-CoV-2 incidence rates were not statistically different in counties with in-person learning versus remote school modes in most regions of the United States. In the South, there was a significant and sustained increase in cases per week among counties that opened in a hybrid or traditional mode versus remote, with weekly effects ranging from 9.8 (95% confidence interval (CI) = 2.7–16.1) to 21.3 (95% CI = 9.9–32.7) additional cases per 100,000 persons, driven by increasing cases among 0–9 year olds and adults. Schools can reopen for in-person learning without substantially increasing community case rates of SARS-CoV-2; however, the impacts are variable. Additional studies are needed to elucidate the underlying reasons for the observed regional differences more fully. Results from a nationwide cohort study in the United States indicates that schools can reopen for in-person learning without substantially increasing community case rates of SARS-CoV-2.
The clinical and microbiological efficacy of temocillin versus cefotaxime in adults with febrile urinary tract infection, and its effects on the intestinal microbiota: a randomised multicentre clinical trial in Sweden
Authors: Charlotta Edlund, Anders Ternhag, Gunilla Skoog Ståhlgren, Petra Edquist, Åse Östholm Balkhed, Simon Athlin, Emeli Månsson, Maria Tempé, Jakob Bergström, Christian G Giske, Håkan Hanberger, Charlotta Edlund, Anders Ternhag, Gunilla Skoog Ståhlgren, Petra Edquist, Åse Östholm Balkhed, Simon Athlin, Emeli Månsson, Maria Tempé, Jakob Bergström, Christian G Giske, Daniel Holmström, Anna-Karin Lindgren, Gisela Otto, Maria Furberg, Johan Fält, Elin Hedman, Håkan Hanberger
Journal: The Lancet Infectious Diseases (2021)
Post-translational Modifications: The Signals at the Intersection of Exercise, Glucose Uptake, and Insulin Sensitivity
Authors: Ben Stocks, Juleen R Zierath
Journal: Endocrine Reviews (2021)

Abstract Diabetes is a global epidemic, of which type 2 diabetes makes up the majority of cases. Nonetheless, for some individuals, type 2 diabetes is eminently preventable and treatable via lifestyle interventions. Glucose uptake into skeletal muscle increases during and in recovery from exercise, with exercise effective at controlling glucose homeostasis in individuals with type 2 diabetes. Furthermore, acute and chronic exercise sensitizes skeletal muscle to insulin. A complex network of signals converge and interact to regulate glucose metabolism and insulin sensitivity in response to exercise. Numerous forms of post-translational modifications (eg, phosphorylation, ubiquitination, acetylation, ribosylation, and more) are regulated by exercise. Here we review the current state of the art of the role of post-translational modifications in transducing exercise-induced signals to modulate glucose uptake and insulin sensitivity within skeletal muscle. Furthermore, we consider emerging evidence for noncanonical signaling in the control of glucose homeostasis and the potential for regulation by exercise. While exercise is clearly an effective intervention to reduce glycemia and improve insulin sensitivity, the insulin- and exercise-sensitive signaling networks orchestrating this biology are not fully clarified. Elucidation of the complex proteome-wide interactions between post-translational modifications and the associated functional implications will identify mechanisms by which exercise regulates glucose homeostasis and insulin sensitivity. In doing so, this knowledge should illuminate novel therapeutic targets to enhance insulin sensitivity for the clinical management of type 2 diabetes.
Reducing ammonia emissions could cheaply cut pollution linked with severe health impacts
Authors: Elisabeth Mahase
Journal: BMJ (2021)

Researchers have found that reducing ammonia emissions could be a cost effective way to limit fine particulate matter air pollution, identified by the World Health Organization as the single largest environmental threat to human health.1

Ammonia—widely used in the production of agricultural fertilisers—is critical to the world food supply, but when released into the air, it bonds with nitrogen oxide and sulphur dioxide to form fine particulates. These particulates, less than 2.5 µm in diameter (PM2.5) are often associated with severe health impacts, including death.

A research team—led by scientists from Zhejiang University in China—used a novel metric called the “nitrogen share” (N-share) of PM2.5 pollution—which is the relative change of total PM2.5 concentration with and without emissions from reactive nitrogens (Nr) …
Proteomics and metabolic phenotyping define principal roles for the aryl hydrocarbon receptor in mouse liver
Authors: Jian Jin, Banrida Wahlang, Monika Thapa, Kimberly Z. Head, Josiah E. Hardesty, Sudhir Srivastava, Michael L. Merchant, Shesh N. Rai, Russell A. Prough, Matthew C. Cave
Journal: Acta Pharmaceutica Sinica B (2021)

Dioxin-like molecules have been associated with endocrine disruption and liver disease. To better understand aryl hydrocarbon receptor (AHR) biology, metabolic phenotyping and liver proteomics were performed in mice following ligand-activation or whole-body genetic ablation of this receptor. Male wild type (WT) and Ahr-/- mice (Taconic) were fed a control diet and exposed to 3,3',4,4',5-pentachlorobiphenyl (PCB126) (61 nmol/kg by gavage) or vehicle for two weeks. PCB126 increased expression of canonical AHR targets (Cyp1a1 and Cyp1a2) in WT but not Ahr-/-. Knockouts had increased adiposity with decreased glucose tolerance; smaller livers with increased steatosis and perilipin-2; and paradoxically decreased blood lipids. PCB126 was associated with increased hepatic triglycerides in Ahr-/-. The liver proteome was impacted more so by Ahr-/- genotype than ligand-activation, but top gene ontology (GO) processes were similar. The PCB126-associated liver proteome was Ahr-dependent. Ahr principally regulated liver metabolism (e.g., lipids, xenobiotics, organic acids) and bioenergetics, but it also impacted liver endocrine response (e.g., the insulin receptor) and function, including the production of steroids, hepatokines, and pheromone binding proteins. These effects could have been indirectly mediated by interacting transcription factors or microRNAs. The biologic roles of the AHR and its ligands warrant more research in liver metabolic health and disease.
A Novel Soluble ACE2 Protein Protects from Lethal SARS-CoV-2 Infection
Authors: Luise Hassler, Jan Wysocki, Ian A. Gelarden, Anastasia Tomatsidou, Haley Gula, Vlad I. Nicolaescu, Glenn Randall, Anjana Yeldandi, Daniel Batlle
Journal: Journal of the American Society of Nephrology (2021)

Background: Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) uses full-length angiotensin converting enzyme 2 (ACE2) as the main receptor to enter the target cells. A novel soluble ACE2 protein with increased duration of action and binding capacity to exert a decoy effect as a way to intercept SARS-CoV-2 from binding to membrane-bound ACE2 was generated. The protein was administered to a lethal mouse model of COVID-19 to examine its efficacy. Methods: A human soluble ACE2 variant fused with a 5kD albumin binding domain (ABD) was linked via a dimerization motif hinge-like 4-cysteine dodecapeptide to improve binding capacity to the SARS-CoV-2. This novel protein (ACE2 1-618-DDCABD) was administered intranasally and intraperitoneally prior to viral inoculation and on the two following consecutive days. Infected animals were observed for weight, clinical score and mortality in a BSL-3 facility. Upon sacrifice, lung histopathology was evaluated, and viral loads were measured by plaque assay. Results: Infected mice that received ACE2-1-618-DDC-ABD developed only moderate disease assessed by a clinical score, modest weight loss and lung histology. At 6 days, mortality was totally prevented in the treated group (figure), lung histopathology was markedly improved and viral lung and brain titers reduced or non-detectable. By contrast, in untreated animals, lung histology revealed extensive pulmonary alveolar hemorrhage and mononuclear infiltrates, and they all became severely ill and had to be euthanized by day 6/7 (figure). Conclusions: This study demonstrates for the first time in vivo the preventative/ therapeutic efficacy of a soluble ACE2 protein in a preclinical animal model.
Abstract 15177: Baseline Testing Does Not Reduce Major Clinical Events After Amiodarone Initiation
Authors: Namrita Trivedi, Kristina Gifft, Jacob Morgan, Greg Petroski, Noelle Al-Khashti, Greg Flaker
Journal: Circulation (2018)

Introduction: Amiodarone can cause many severe multi-organ toxicities. Strategies to ensure safe use include the performance of lung, liver, and thyroid studies at initiation of amiodarone. If radi...
Molecular Pathogenesis of Gastrointestinal Stromal Tumor: A Paradigm for Personalized Medicine
Authors: Josephine K. Dermawan, Brian P. Rubin
Journal: Annual Review of Pathology Mechanisms of Disease (2021)

Over the past three to four decades, the molecular pathogenesis of gastrointestinal stromal tumors (GISTs) has been elucidated in great detail. In this review, we discuss the biological genesis of GISTs, identification of the various primary activating driver mutations (focusing on KIT and PDGFRA), oncogene addiction and targeted therapies with imatinib and other tyrosine kinase inhibitors, and the subsequent characterization of the various mechanisms of drug resistance. We illustrate how GIST has become a quintessential paradigm for personalized medicine.
TCT-281 Reasons for Less Than Maximal Target Doses of Heart Failure Medications in Patients Enrolled in the COAPT Trial
Authors: Sandip Zalawadiya, Zachary Cox, Matheus Simonato, Bjorn Redfors, Michael Zile, Scott Lim, Zhipeng Zhou, Lak Kotinkaduwa, Michael Mack, William Abraham, Gregg Stone, JoAnn Lindenfeld
Journal: Journal of the American College of Cardiology (2021)
PHQ-8 scores and estimation of depression prevalence
Authors: Brooke Levis, Felix Fischer, Andrea Benedetti, Brett D Thombs
Journal: The Lancet Public Health (2021)

In the Article by Jorge Arias-de la Torre and colleagues,1 the authors used data for 258 888 individuals obtained from the second wave of the European Health Interview Survey to estimate depression prevalence in 27 European countries based on scores of 10 or higher on the eight-item Patient Health Questionnaire (PHQ-8). The authors reported an overall prevalence of current depressive disorder of 6·38% (95% CI 6·24–6·52) with substantial heterogeneity across countries.1
2-Year Outcomes of Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation
Authors: David W M Muller, Paul Sorajja, Alison Duncan, Brian Bethea, Gry Dahle, Paul Grayburn, Vasilis Babaliaros, Mayra Guerrero, Vinod H Thourani, Francesco Bedogni, Paolo Denti, Nicolas Dumonteil, Thomas Modine, Paul Jansz, Michael L Chuang, Philipp Blanke, Jonathon Leipsic, Vinay Badhwar
Journal: Journal of the American College of Cardiology (2021)
LocoMMotion: A Prospective, Non-Interventional, Multinational Study of Real-Life Current Standards of Care in Patients With Relapsed/Refractory Multiple Myeloma Who Received ≥3 Prior Lines of Therapy
Authors: Philippe Moreau, Katja Weisel, Valerio De Stefano, Hartmut Goldschmidt, Michel Delforge, Mohamad Mohty, Michele Cavo, Ravi Vij, Joanne Lindsey-Hill, Dominik Dytfeld, Emanuele Angelucci, Aurore Perrot, Reuben Benjamin, Niels W.C.J. Van de Donk, Enrique Ocio, Christof Scheid, Francesca Gay, Wilfried Roeloffzen, Paula Rodriguez-Otero, Annemiek Broyl, Anna Potamianou, Caline Sakabedoyan, Maria Semerjian, Sofia Keim, Vadim Strulev, Jordan M. Schecter, Martin Vogel, Robert Wapenaar, Tonia Nesheiwat, Jesus San-Miguel, Pieter Sonneveld, Hermann Einsele, Maria-Victoria Mateos
Journal: Blood (2021)
TCT-181 Trends, Predictors, and Outcomes of Transcatheter Aortic Valve Implantation in Patients With Aortic Insufficiency: A National Inpatient Sample Database Analysis
Authors: Heba Osman, Waqas Ullah, Abdul-Rahman Suleiman, Mohamed Zghouzi, Yasar Sattar, Salman Zahid, Chaitu Dandu, Adam Chalek, David Fischman, M. Chadi Alraies
Journal: Journal of the American College of Cardiology (2021)
Heart Rate Recovery after Submaximal Exercise Test and 20 Year All-Cause Mortality Test in Asymptomatic Russian and American Men: The Lipid Research Clinics Study
Authors: Georgeta D Vaidean, Alexander Deev, Jeffrey Abolafia, Dmitri Shestov, Edward C Davis
Journal: Circulation (2001)

P76 Background. Heart Rate Recovery at two minutes post exercise (HRR2) was reported to be a predictor of death in the US-Lipid Research Clinics (LRC) Study. Objective. To extend study of HRR2 to the USSR-LRC population, with higher mortality rates and cardiovascular (CVD) risk factor levels. Design and methods. Among the LRC cohorts, using a standardized protocol, HRR2 after a treadmill submaximal test and CVD risk factors was measured in 1294 Russian and 1589 American men ages 39-60 years, free of coronary disease at baseline, not taking cardio-active drugs, followed for an average of 17.5 years for all cause mortality. Kaplan-Meier curves and stratified Cox proportional hazard models were employed for analysis. Results.There were 391 (30.2%) deaths in the Russian and 232 (14.6%) in the American men, and mean HRR2 was 59.6 bpm (95% CI 58.3-60.3) and 53.2 (CI 52.6-53.8) respectively. All cause mortality increased monotonically with decreasing HRR2 and was predicted by HRR2 adjusting for age, physical fitness, ST-T response, cholesterol and blood pressure, and alcohol intake in both samples. For each 15 bpm (1 SD) decrease in HRR2 the crude hazard rate ratio was 1.61 (95% CI 1.37, 1.89) in Russian and 1.37 (1.23, 1.51) in American men among smokers; upon adjustment the values were 1.34 (95% CI 1.16-1.56) and 1.39 (1.13-1.70) respectively. Conclusion. Delay in the recovery of heart rate after a submaximal exercise test was associated with all cause mortality, statistically independent of cardiovascular risk factors in both Russian and American men.The extension of these associations to a higher risk population, suggests the potential utility of HRR2 for CVD risk assessment.
Impact of a rare respiratory diseases reference centre set-up on primary ciliary dyskinesia care pathway
Authors: Salome Epaud, Ralph Epaud, Noemie Salaün-Penquer, Ekaterina Belozertseva, Natascha Remus, Benoit Douvry, Emilie Bequignon, Andre Coste, Virginie Prulière-Escabasse, Frédéric Schlemmer, Camille Jung, Matthieu Ortala, Bernard Maitre, Céline Delestrain
Journal: European Respiratory Journal (2021)

<b>This study shows that the creation of the Rare Lung Diseases Centre impacted the PCD patient care pathway with an increase in physiotherapist and paediatric pulmonology consultations, and a decrease of emergency department visits</b>https://bit.ly/3BfsVWr
Quantitative conservation geography
Authors: Enrico Di Minin, Ricardo A. Correia, Tuuli Toivonen
Journal: Trends in Ecology & Evolution (2021)

Ongoing biodiversity loss represents the erosion of intrinsic value of living nature, reduces the contributions nature provides to people, and undermines efforts to move towards sustainability. We propose the recognition of quantitative conservation geography as a subfield of conservation science that studies where, when, and what conservation actions could be implemented in order to mitigate threats and promote sustainable people-nature interactions. We outline relevant methods and data needed in quantitative conservation geography. We also discuss the importance of filling information gaps, for example by using emerging technologies and digital data sources, for the further advancement of this subfield. Quantitative conservation geography can help inform the implementation of national and international conservation actions and policy to help stem the global biodiversity crisis.
A programmable hierarchical-responsive nanoCRISPR elicits robust activation of endogenous target to treat cancer
Authors: Chao Liu, Ning Wang, Rui Luo, Lu Li, Wen Yang, Xiye Wang, Meiling Shen, Qinjie Wu, Changyang Gong
Journal: Theranostics (2021)

Despite promising progress of cancer gene therapy made, these therapeutics were still limited by the diversity of gene sizes and types. CRISPR/dCas9 mediated activation of tumor endogenous gene has shown great potential to surmount hinders of genetic varieties during the process of cancer gene therapy. However, the blood interference along with complicated tumor extra/intracellular microenvironment substantially compromise the performance of CRISPR/dCas9-based therapeutics
Coronary flowに影響する血栓の特徴~PercuSurgeにて吸引された血栓所見による検討~
Authors: 森田康弘, 曽根孝仁, 坪井英之, 武川博昭, 森島逸郎, 里田雅彦, 上杉道伯, 高木健督, 林英次郎
Journal: Circulation (2004)
The biological effect of recombinant humanized collagen on damaged skin induced by UV-photoaging: An in vivo study
Authors: Jing Wang, He Qiu, Yang Xu, Yongli Gao, Peijie Tan, Rui Zhao, Zhanhong Liu, Yajun Tang, Xiangdong Zhu, Chongyun Bao, Hang Wang, Hai Lin, Xingdong Zhang
Journal: Bioactive Materials (2021)

The application of medical devices to repair skin damage is clinically accepted and natural polymer enjoys an important role in this field, such as collagen or hyaluronic acid, etc. However, the biosafety and efficacy of these implants are still challenged. In this study, a skin damage animal model was prepared by UV-photoaging and recombinant humanized type III collagen (rhCol III) was applied as a bioactive material to implant in vivo to study its biological effect, comparing with saline and uncrosslinked hyaluronic acid (HA). Animal skin conditions were non-invasively and dynamically monitored during the 8 weeks experiment. Histological observation, specific gene expression and other molecular biological methods were applied by the end of the animal experiment. The results indicated that rhCol III could alleviate the skin photoaging caused by UV radiation, including reduce the thickening of epidermis and dermis, increase the secretion of Collagen I (Col I) and Collagen III (Col III) and remodel of extracellular matrix (ECM). Although the cell-material interaction and mechanism need more investigation, the effect of rhCol III on damaged skin was discussed from influence on cells, reconstruction of ECM, and stimulus of small biological molecules based on current results. In conclusion, our findings provided rigorous biosafety information of rhCol III and approved its potential in skin repair and regeneration. Although enormous efforts still need to be made to achieve successful translation from bench to clinic, the recombinant humanized collagen showed superiorities from both safety and efficacy aspects.
Clinical Translation of Basic Science in Asthma
Authors: Philip G. Bardin, Paul S. Foster
Journal: New England Journal of Medicine (2021)

Basic science has enriched our understanding of the pathophysiology of severe asthma. Clinical translation of these discoveries has resulted in biologic therapies that target key components of asthma-related disease pathways. For example, identification and validation of biomarkers such as elevated blood eosinophil counts made it possible to implement tailored biologic treatments targeting the function of cytokines such as interleukin-5, interleukin-4, and interleukin-13.1 The success of these strategies has prompted investigations of other molecules that are active in the pathogenesis of severe asthma. The results of two pertinent trials are reported in this issue of the Journal. In a randomized, controlled, . . .
Askochensky brothers: Arystarkh — a doctor, Victor — a publicist
Authors: M.P. Chaban, Z.I. Shevtsova, V.V. Gaponov
Journal: GASTROENTEROLOGY (2021)

The article presents the life path and professional activity of Askochensky brothers from the clergy family. The elder brother Victor (1813–1879) chose for himself the mission of improving and developing the spiritual sphere of a person. The younger brother Arystarkh (1817–1896) received medical education. He worked as a zemstvo doctor in the Yekaterynoslav region (modern Dnipro-petrovsk region). He became a doctor of medicine, a military doctor. The Askochensky brothers made a significant contribution to the development of medical science and practice, to the journalistic and cultural-educational spheres.