tbuckley/cabot-search huggingface dataset:
Association of Serum Aldosterone and Plasma Renin Activity With Ambulatory Blood Pressure in African Americans: The Jackson Heart Study
Authors: Joshua J. Joseph, Neal K. Pohlman, Songzhu Zhao, David Kline, Guy Brock, Justin B. Echouffo-Tcheugui, Mario Sims, Valery S. Effoe, Wen-Chih Wu, Rita R. Kalyani, Gary S. Wand, Bjorn Kluwe, Willa A. Hsueh, Marwah Abdalla, Daichi Shimbo, Sherita H. Golden
Journal: Circulation (2021)

Background: The renin-angiotensin-aldosterone system (RAAS) is an important driver of blood pressure (BP), but the association of the RAAS with ambulatory BP (ABP) and ABP monitoring phenotypes among African Americans has not been assessed. Methods: ABP and ABP monitoring phenotypes were assessed in 912 Jackson Heart Study participants with aldosterone and plasma renin activity (PRA). Multivariable linear and logistic regression analyses were used to analyze the association of aldosterone and PRA with clinic, awake, and asleep systolic BP and diastolic BP (DBP) and ABP monitoring phenotypes, adjusting for important confounders. Results: The mean age of participants was 59±11 years and 69% were female. In fully adjusted models, lower log-PRA was associated with higher clinic, awake, and asleep systolic BP and DBP (all P &lt;0.05). A higher log-aldosterone was associated with higher clinic, awake, and asleep DBP (all P &lt;0.05). A 1-unit higher log-PRA was associated with lower odds of daytime hypertension (odds ratio [OR] 0.59 [95% CI, 0.49–0.71]), nocturnal hypertension (OR, 0.68 [95% CI, 0.58–0.79]), daytime and nocturnal hypertension (OR, 0.59 [95% CI, 0.48–0.71]), sustained hypertension (OR, 0.52 [95% CI, 0.39–0.70]), and masked hypertension (OR 0.75 [95% CI, 0.62–0.90]). A 1-unit higher log-aldosterone was associated with higher odds of nocturnal hypertension (OR, 1.38 [95% CI, 1.05–1.81]). Neither PRA nor aldosterone was associated with percent dipping, nondipping BP pattern, or white-coat hypertension. Patterns for aldosterone:renin ratio were similar to patterns for PRA. Conclusions: Suppressed renin activity and higher aldosterone:renin ratios were associated with higher systolic BP and DBP in the office and during the awake and asleep periods as evidenced by ABP monitoring. Higher aldosterone levels were associated with higher DBP, but not systolic BP, in the clinic and during the awake and asleep periods. Further clinical investigation of novel and approved medications that target low renin physiology such as epithelial sodium channel inhibitors and mineralocorticoid receptor antagonists may be paramount in improving hypertension control in African Americans.
PLoS Medicine Issue Image | Vol. 4(4) April 2007
Journal: PLoS Medicine (2007)

The cover image takes its theme from the paper by Leonidas Koniaris and colleagues. Data from executions in the US suggest that current lethal injection protocols do not effect death through the mechanisms intended, and that potentially aware inmates could die through pancuronium-induced asphyxiation. The humaneness of lethal injection is discussed further in the accompanying Editorial. Image Credit: Image provided by California Department of Corrections and Rehabilitation
Loss of CASK Accelerates Heart Failure Development
Authors: Julian Mustroph, Can M. Sag, Felix Bähr, Anna-Lena Schmidtmann, Shamindra N. Gupta, Alexander Dietz, M.M. Towhidul Islam, Charlotte Lücht, Bo Eric Beuthner, Steffen Pabel, Maria J. Baier, Ali El-Armouche, Samuel Sossalla, Mark E. Anderson, Julia Möllmann, Michael Lehrke, Nikolaus Marx, Peter J. Mohler, Donald M. Bers, Bernhard Unsöld, Tao He, Matthias Dewenter, Johannes Backs, Lars S. Maier, Stefan Wagner
Journal: Circulation Research (2021)

[Figure: see text].
Errors in Table 2
Authors: Yongzhen Fan, Tao Guo, Zhibing Lu
Journal: JAMA Cardiology (2020)

Michel Le May, MD; George Wells, PhD; Derek So, MD; Aun Yeong Chong, MD; Alexander Dick, MD; Michael Froeschl, MD; Christopher Glover, MD; Benjamin Hibbert, MD; Jean-Francois Marquis, MD; Melissa Blondeau, BSc; Christina Osborne, BSc; Andrea MacDougall, MD; Malek Kass, MD; Vernon Paddock, MD; Ata Quraishi, MBBS; Marino Labinaz, MD
Influence of cirrhosis on outcomes of patients with advanced intrahepatic cholangiocarcinoma receiving chemotherapy.
Authors: Constance D'abrigeon, Mairead Geraldine McNamara, Samuel Le Sourd, Angela Lamarca, Astrid Lièvre, Richard A Hubner, Juan W. Valle, Julien Edeline
Journal: Journal of Clinical Oncology (2022)

475 Background: Cirrhosis is a risk factor for intrahepatic cholangiocarcinoma (iCC). However, its impact on the management of advanced disease is not established. Methods: Retrospective analysis of patients (pts) treated with systemic chemotherapy for advanced iCC in the first-line setting at 2 tertiary cancer referral centers, the second center used to validate findings from the first. Cirrhosis was diagnosed based on at least one element among pathological diagnosis, baseline platelet &lt; 150 G/L, portal hypertension and/or dysmorphic liver at imaging. Results: In the first center (n=185), 55 pts (29.7%) had cirrhosis (74.5 % based on pathological diagnosis). Main aetiology of cirrhosis was alcohol for 17 pts (31%), non-alcoolic steato-hepatitis (NASH) for 10 pts (18.2%), and mixed alcohol and NASH for 9 pts (16.4%). 102 (57.0%) pts received gemcitabine-cisplatin, 55 (30.7%) pts received gemcitabine-oxaliplatin, and 11 (6%) pts received gemcitabine, with no difference between cirrhotic and non-cirrhotic pts (p=0.38). Second-line treatment was less frequent in cirrhotic pts (21.8% vs. 50.0%, p=0.001). Cirrhotic pts experienced more grade 3/4 hematologic toxicity than non-cirrhotic pts (38% vs. 20%, respectively, p=0,014), and more grade 3/4 non-hematologic toxicity (28% vs. 15%, respectively, p=0.048). The overall survival (OS) was significantly shorter in cirrhotic pts; median: 9.0 vs. 13.8 months for non-cirrhotic pts (HR = 1.54 [95%CI: 1.09-2.16]; p = 0.014); confirmed on multivariable analysis, adjusted on ALBI-score, ECOG PS, extension of the disease (liver only disease and bilobar) (HR = 1.53 [95% CI: 1.01-2.33]; p=0.046). However, PFS was not significantly shorter in cirrhotic pts: median 9,9 months vs. 11.7 for non-cirrhotics (p = 0.35). In the second center (n=102), similar results were seen: 27 (26.5%) pts had cirrhosis. The cirrhotic pts experienced more grade 3/4 hematologic toxicities than non-cirrhotic pts (55.6% vs. 25.4%, respectively, p=0.005), and more grade 3/4 non-hematologic toxicity (44.4% vs. 12.7%, respectively, p = 0.001). OS was shorter in cirrhotic pts; median 9.1 months vs. 11.7 months for non-cirrhotic pts (HR = 1.81 [95%CI: 1.14-2.87]; p = 0.011). PFS was not significantly shorter in cirrhotic pts: 7.5 months for patients without cirrhosis, and 4.2 months for pts with cirrhosis (p=0.221). Conclusions: Cirrhosis was frequent in pts with advanced iCC, and had a negative impact on patients’ outcomes, with increased chemotherapy-induced toxicity and shorter OS. Formal assessment and consideration of cirrhosis in the therapeutic management should be recommended and could lead to a dose adjustment.
Arboviruses and COVID-19: the need for a holistic view
Authors: None The Lancet Microbe
Journal: The Lancet Microbe (2020)

In June, the Pan American Health Organization (PAHO) and WHO published their latest epidemiological update on dengue and other arboviruses. They state that, during the first few months of 2020 (epidemiological week 1–21), there were more than 1·6 million reported cases of arboviral disease in the WHO region of the Americas. Most of these (about 97%) were dengue and the rest were chikungunya (>2%) and Zika (<1%). This prevalence is much lower than that reported in the same period in 2019. A major factor in this overall decrease was a large reduction in cases of chikungunya and Zika virus infection, although cases of dengue also decreased.
Heart-type fatty acid-binding protein is more useful than cardiac troponin T and CK-MB isoforms for risk stratification in patients with acute coronary syndrome within 3 hrs after onset of chest pain Junnichi Ishii, Masanori Nomura, Hiroyuki Naruse, Yoshihisa Mori, Toshikazu Ando, Hiroshi Kurokawa, Takeshi Kondo, Yoshihiko Watanabe, Hitoshi Hishida. Fujita Health University, Toyoake, Japan
Journal: Journal of the American College of Cardiology (2001)
Engineering pro-angiogenic biomaterials via chemoselective extracellular vesicle immobilization
Authors: Yunhui Xing, Saigopalakrishna S. Yerneni, Weitao Wang, Rebecca E. Taylor, Phil G. Campbell, Xi Ren
Journal: Biomaterials (2021)

Nanoscale extracellular vesicles (EVs) represent a unique cellular derivative that reflect the therapeutic potential of mesenchymal stem cells (MSCs) toward tissue engineering and injury repair without the logistical and safety concerns of utilizing living cells. However, upon systemic administration in vivo,EVs undergo rapid clearance and typically lack controlled targeted delivery, thus reducing their effectiveness in therapeutic regenerative therapies. Here, we describe a strategy that enables long-term in vivo spatial EV retention by chemoselective immobilization of metabolically incoporated azido ligand-bearing EVs (azido-EVs) within a dibenzocyclooctyne-modified collagen hydrogel. MSC-derived azido-EVs exhibit comparable morphological and functional properties as their non-labeled EV counterparts and, when immobilized within collagen hydrogel implants via click chemistry, they elicited more robust host cell infiltration, angiogenic and immunoregulatory responses including vascular ingrowth and macrophage recruitment compared to ten times the higher dose required by non-immobilized EVs. We envision this technology will enable a wide range of applications to spatially promote vascularization and host integration relevant to tissue engineering and regenerative medicine applications.
Acute effects of endovascular photpdynamic therapy on femoral atherosclerotic lesions in hypercholesterolemic rabbits J. William Phillips, Tamara E. Bogetti, Christina A. Waters, Sean E. Hesselbacher, Ross Heath, Robert I. Grove, Steve Rychnovsky, Jeff Walker, Ian J. Sarembock. University of Virginia, Charlottesville, VA, Miravant Medical Technologies, Santa Barbara, CA
Journal: Journal of the American College of Cardiology (2001)
Prescribing protease inhibitors for the homeless
Authors: A. Lyman
Journal: JAMA (1997)

<h3>In Reply.</h3> —We appreciate the comments from Drs Ickowics and Chesney, Frenkel and Melvin, and Fischer with regard to our consensus recommendations for antiretroviral therapy in HIV infection in adults. We concur with the need for prospectively designed adherence assessments during controlled clinical trials of antiretroviral drugs and fully agree that such trials provide a unique opportunity (and a compelling mandate) to carry out interdisciplinary investigations that will enhance clinical practice. The recommendations of our panel are directed toward HIV infection in adults and, as Frenkel and Melvin discuss, there remains an urgent need to conduct detailed studies of potent antiretroviral regimens in infants and in young children. We concur with Fischer's comments with regard to antiretroviral therapy for HIV-infected pregnant women; the US Public Health Service has recently released draft guidelines that provide more specific recommendations for aggressive antiretroviral therapy in this setting,<sup>1</sup>1 which are available from the National
Error in the Methods Section
Journal: JAMA Network Open (2021)

Nikitha K. Menon, BA; Tait D. Shanafelt, MD; Christine A. Sinsky, MD; Mark Linzer, MD; Lindsey Carlasare, MBA; Keri J. S. Brady, MPH, PhD; Martin J. Stillman, MD, JD; Mickey T. Trockel, MD, PhD
JAMA Reference Directories
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phenotypic Heterogeneity in Chronic Obstructive Pulmonary Disease
Authors: Malvika Kaul, Solomon Krow, Ai-Yui M. Tan, Sunit Singla
Journal: American Journal of Respiratory and Critical Care Medicine (2021)

"Phenotypic Heterogeneity in Chronic Obstructive Pulmonary Disease." American Journal of Respiratory and Critical Care Medicine, 205(1), pp. 118–120
COVID-19 in Latin America: a humanitarian crisis
Authors: None The Lancet
Journal: The Lancet (2020)

Latin America has some of the highest COVID-19 death rates in the world. Why? For outsiders, much of the discussion of COVID-19 in Latin America has focused on Brazil and the errors of President Jair Bolsonaro. But the region as a whole is facing a humanitarian crisis borne out of political instability, corruption, social unrest, fragile health systems, and perhaps most importantly, longstanding and pervasive inequality—in income, health care, and education—which has been woven into the social and economic fabric of the region.
Pancreatic cancer: Cutaneous metastases, clinical descriptors and outcomes.
Authors: Lilly Gu, Mehta Paras, Devika Rao, Veronica Rotemberg, Marinela Capanu, Joanne F. Chou, Carlie S. Sigel, Klaus J. Busam, Lindsay Boyce, Allison Gordon, Eileen Mary O'Reilly
Journal: Journal of Clinical Oncology (2022)

615 Background: The occurrence of cutaneous metastasis from pancreatic cancer (PC) is rare, and the exact incidence is unknown. The literature to date is primarily limited to isolated case reports. Herein, we evaluate the clinical, genomic, and other descriptors of patients with PC and cutaneous metastases. Methods: Institutional databases were queried using search terms “pancreas cancer” and “cutaneous mets”. Clinical history, demographics, PC cutaneous metastasis details, and survival outcomes were abstracted. Results were described using descriptive statistics, and overall survival (OS) from the diagnosis of cutaneous metastasis was estimated using Kaplan-Meier methods. Results: Of 140 on initial search, 40 patients met inclusion criteria of PC and cutaneous metastases and were analyzed. The median age (Q1-Q3, IQR) of pancreatic cancer diagnosis was 66.0 (59.3-72.3, 12.9) years. Most common histologic subtype was adenocarcinoma (n= 39, 98%), and one patient had a neuroendocrine malignancy. Most patients had stage IV disease at diagnosis (n=26, 65%). The most common location of the primary tumor was tail of the pancreas (n=17, 43%). Forty-eight percent (n= 19) had cutaneous metastasis at/within one month of cancer diagnosis. Most patients received chemotherapy (n=37, 93%), with 14 patients (35%) patients also receiving local therapy in the form of local excision or radiation. The most common cutaneous metastasis site was the abdomen (n=40, 66%), with umbilical lesions occurring in 58% (n=23) of abdominal lesions. The median interval (Q1-Q3, IQR) between diagnosis of pancreatic cancer and development of cutaneous metastasis was 1.4 (0-14.5, 14.5) months. The median OS (95% CI) from cutaneous metastasis diagnosis was 11 months (7.0, 20). Table details the observed differences between umbilical vs. non-umbilical metastases. Sixteen of 40 (40%) patients underwent somatic testing. The most frequently mutated genes were KRAS (n= 16, 100%), TP53 (n=7, 44%), CDKN2Ap14ARF (n=5, 31%), CDKN2Ap16INK4A (n=5, 31%), and CDKN2B (n=3, 19%). Germline testing was undertaken in 12 (30%) patients, and pathogenic variants were observed in 3: CHEK2 (n=1, 8%), BRCA1 (n=1, 8%), and ATM (n= 1, 8%). Summary of cutaneous metastasis characteristics. Conclusions: Cutaneous metastases from PC are rare and can be present at the time of diagnosis of stage IV disease, occurring most frequently in the umbilicus. Cutaneous metastases can be classified into umbilical and non-umbilical metastases, which may be due to a different biology.[Table: see text]
Medical education in the United States, 1972-1973
Authors: P Jolly
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Section of Ophthalmology: Errata
Journal: BMJ (1903)

ouulLTE OTDr. Hollinder tlhat it is not in England considered proper for a medic al man, when' writing expressly for 'the lay public, to quote from his pro- fessional case-books, as 'is donc for instance on pages I22 and 133 of the book referred to.Secondly, it is surcly soiimewhat misleading for any one professing expert scientific knowledge to state to the public that: "It is a universally accepted fact that the size of the brain is a measure- ment of mental power " (page 25I).Thirdly, theautlhor in several 'places, for example, pages 295 and io6, makes virulent attacks upon vivisection, which naturally affords no support to the fanciful tlheories put :forward by him.We consider that the chlief danger of his book is the effect which it may have upon the non-scientiflc reader.Medical men are lhardly likely to take it seriously.TREATMENT OF PROSTATITIS.
Deaths and Obituaries.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Residency Program Accreditation Advancements
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
High‐Throughput On‐Chip Human Mesenchymal Stromal Cell Potency Prediction (Adv. Healthcare Mater. 2/2022)
Authors: Rebecca S. Schneider, Alexandra C. Vela, Evelyn Kendall Williams, Karen E. Martin, Wilbur A. Lam, Andrés J. García
Journal: Advanced Healthcare Materials (2022)

On-Chip Technologies In article number 2101995, using 3D encapsulation and microfluidics, Andrés J. García and co-workers engineer a high-throughput on-chip human mesenchymal stromal cell (MSC) potency assay with improved functional potency prediction compared to traditional 2D potency assays. Further results demonstrate improved in vivo secretory recapitulation of on-chip MSCs in compared to traditional 2D cultures.