Risk Factors Associated With Mortality and Neurologic Disability After Intracerebral Hemorrhage in a Racially and Ethnically Diverse Cohort
Authors: Daniel Woo, Mary E. Comeau, Simone Uniken Venema, Christopher D. Anderson, Matthew Flaherty, Fernando Testai, Steven Kittner, Michael Frankel, Michael L. James, Gene Sung, Mitchell Elkind, Bradford Worrall, Chelsea Kidwell, Nicole Gonzales, Sebastian Koch, Christiana Hall, Lee Birnbaum, Douglas Mayson, Bruce Coull, Marc Malkoff, Kevin N. Sheth, Jacob L. McCauley, Jennifer Osborne, Misty Morgan, Lee Gilkerson, Tyler Behymer, Elisheva R. Coleman, Jonathan Rosand, Padmini Sekar, Charles J. Moomaw, Carl D. Langefeld
Journal: JAMA Network Open (2022)

<h3>Introduction</h3> Intracerebral hemorrhage (ICH) is the most severe subtype of stroke. Its mortality rate is high, and most survivors experience significant disability. <h3>Objective</h3> To assess primary patient risk factors associated with mortality and neurologic disability 3 months after ICH in a large, racially and ethnically balanced cohort. <h3>Design, Setting, and Participants</h3> This cohort study included participants from the Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study, which prospectively recruited 1000 non-Hispanic White, 1000 non-Hispanic Black, and 1000 Hispanic patients with spontaneous ICH to study the epidemiological characteristics and genomics associated with ICH. Participants included those with uniform data collection and phenotype definitions, centralized neuroimaging review, and telephone follow-up at 3 months. Analyses were completed in November 2021. <h3>Exposures</h3> Patient demographic and clinical characteristics as well as hospital event and imaging variables were examined, with characteristics meeting P &lt; .20 considered candidates for a multivariate model. Elements included in the ICH score were specifically analyzed. <h3>Main Outcomes and Measures</h3> Individual characteristics were screened for association with 3-month outcome of neurologic disability or mortality, as assessed by a modified Rankin Scale (mRS) score of 4 or greater vs 3 or less under a logistic regression model. A total of 25 characteristics were tested in the final model, which minimized the Akaike information criterion. Analyses were repeated removing individuals who had withdrawal of care. <h3>Results</h3> A total of 2568 patients (mean [SD] age, 62.4 [14.7] years; 1069 [41.6%] women and 1499 [58.4%] men) had a 3-month outcome determination available, including death. The final logistic model had a significantly higher area under the receiver operating characteristics curve (<i>C</i> = 0.88) compared with ICH score alone (<i>C</i> = 0.76;<i>P</i> &lt; .001). Among characteristics associated with neurologic disability and mortality were larger log ICH volume (OR, 2.74; 95% CI, 2.36-3.19;<i>P</i> &lt; .001), older age (OR per 1-year increase, 1.04; 95% CI, 1.02-1.05;<i>P</i> &lt; .001), pre-ICH mRS score (OR, 1.62; 95% CI, 1.41-1.87;<i>P</i> &lt; .001), lobar location (OR, 0.22; 95% CI, 0.16-0.30;<i>P</i> &lt; .001), and presence of infection (OR, 1.85; 95% CI, 1.42-2.41;<i>P</i> &lt; .001). <h3>Conclusions and Relevance</h3> The findings of this cohort study validate ICH score elements and suggest additional baseline and interim patient characteristics were associated with variation in 3-month outcome.