tbuckley/cabot-search huggingface dataset:
<i>Fusobacterium nucleatum</i> drives a pro-inflammatory intestinal microenvironment through metabolite receptor-dependent modulation of IL-17 expression
Authors: Caitlin A. Brennan, Slater L. Clay, Sydney L. Lavoie, Sena Bae, Jessica K. Lang, Diogo Fonseca-Pereira, Kathryn G. Rosinski, Nora Ou, Jonathan N. Glickman, Wendy S. Garrett
Journal: Gut Microbes (2021)

The colorectal cancer (CRC)-associated microbiota creates a pro-tumorigenic intestinal milieu and shapes immune responses within the tumor microenvironment. However, how oncomicrobes – like Fusobacterium nucleatum, found in the oral cavity and associated with CRC tissues– affect these distinct aspects of tumorigenesis is difficult to parse. Herein, we found that neonatal inoculation of ApcMin/+ mice with F. nucleatum strain Fn7-1 circumvents technical barriers preventing its intestinal colonization, drives colonic Il17a expression prior to tumor formation, and potentiates intestinal tumorigenesis. Using gnotobiotic mice colonized with a minimal complexity microbiota (the altered Schaedler's flora), we observed that intestinal Fn7-1 colonization increases colonic Th17 cell frequency and their IL-17A and IL-17F expression, along with a concurrent increase in colonic lamina propria Il23p19 expression. As Fn7-1 stably colonizes the intestinal tract in our models, we posited that microbial metabolites, specifically short-chain fatty acids (SCFA) that F. nucleatum abundantly produces in culture and, as we demonstrate, in the intestinal tract, might mediate part of its immunomodulatory effects in vivo. Supporting this hypothesis, we found that Fn7-1 did not alter RORγt+ CD4+T cell frequency in the absence of the SCFA receptor FFAR2. Taken together, our work suggests that F. nucleatum influences intestinal immunity by shaping Th17 responses in an FFAR2-dependent manner, although further studies are necessary to clarify the precise and multifaceted roles of FFAR2. The potential to increase intestinal Th17 responses is shared by another oncomicrobe, enterotoxigenic Bacteroides fragilis, highlighting a conserved pathway that could potentially be targeted to slow oncomicrobe-mediated CRC.
Treatment of chronic or relapsing COVID-19 in immunodeficiency
Authors: Li-An K. Brown, Ed Moran, Anna Goodman, Helen Baxendale, William Bermingham, Matthew Buckland, Iman AbdulKhaliq, Hannah Jarvis, Michael Hunter, Surendra Karanam, Aisha Patel, Megan Jenkins, Alexander Robbins, Sujoy Khan, Thomas Simpson, Stephen Jolles, Jonathan Underwood, Sinisa Savic, Alex Richter, Adrian Shields, Michael Brown, David M. Lowe
Journal: Journal of Allergy and Clinical Immunology (2021)
Author Correction: A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease
Authors: Douglas P. Wightman, Iris E. Jansen, Jeanne E. Savage, Alexey A. Shadrin, Shahram Bahrami, Dominic Holland, Arvid Rongve, Sigrid Børte, Bendik S. Winsvold, Ole Kristian Drange, Amy E. Martinsen, Anne Heidi Skogholt, Cristen Willer, Geir Bråthen, Ingunn Bosnes, Jonas Bille Nielsen, Lars G. Fritsche, Laurent F. Thomas, Linda M. Pedersen, Maiken E. Gabrielsen, Marianne Bakke Johnsen, Tore Wergeland Meisingset, Wei Zhou, Petroula Proitsi, Angela Hodges, Richard Dobson, Latha Velayudhan, Karl Heilbron, Adam Auton, Michelle Agee, Stella Aslibekyan, Elizabeth Babalola, Robert K. Bell, Jessica Bielenberg, Katarzyna Bryc, Emily Bullis, Briana Cameron, Daniella Coker, Gabriel Cuellar Partida, Devika Dhamija, Sayantan Das, Sarah L. Elson, Teresa Filshtein, Kipper Fletez-Brant, Pierre Fontanillas, Will Freyman, Pooja M. Gandhi, Barry Hicks, David A. Hinds, Karen E. Huber, Ethan M. Jewett, Yunxuan Jiang, Aaron Kleinman, Katelyn Kukar, Vanessa Lane, Keng-Han Lin, Maya Lowe, Marie K. Luff, Jey C. McCreight, Matthew H. McIntyre, Kimberly F. McManus, Steven J. Micheletti, Meghan E. Moreno, Joanna L. Mountain, Sahar V. Mozaffari, Priyanka Nandakumar, Elizabeth S. Noblin, Jared O’Connell, Aaron A. Petrakovitz, G. David Poznik, Morgan Schumacher, Anjali J. Shastri, Janie F. Shelton, Jingchunzi Shi, Suyash Shringarpure, Chao Tian, Vinh Tran, Joyce Y. Tung, Xin Wang, Wei Wang, Catherine H. Weldon, Peter Wilton, Julia M. Sealock, Lea K. Davis, Nancy L. Pedersen, Chandra A. Reynolds, Ida K. Karlsson, Sigurdur Magnusson, Hreinn Stefansson, Steinunn Thordardottir, Palmi V. Jonsson, Jon Snaedal, Anna Zettergren, Ingmar Skoog, Silke Kern, Margda Waern, Henrik Zetterberg, Kaj Blennow, Eystein Stordal, Kristian Hveem, John-Anker Zwart, Lavinia Athanasiu, Per Selnes, Ingvild Saltvedt, Sigrid B. Sando, Ingun Ulstein, Srdjan Djurovic, Tormod Fladby, Dag Aarsland, Geir Selbæk, Stephan Ripke, Kari Stefansson, Ole A. Andreassen, Danielle Posthuma
Journal: Nature Genetics (2021)
Cellular Immune Responses to BNT162b2 mRNA COVID-19 Vaccine in Patients with Chronic Lymphocytic Leukemia
Authors: Gilad Itchaki, Lior Rokach, Ohad Benjamini, Osnat Bairey, Adi Sabag, Helly Vernitsky, Hila Cohen, Shahar Rotem, Uri Elia, Pia Raanani, Erez Bar-Haim, Tamar Tadmor
Journal: Blood (2021)
Venetoclax Plus Azacitidine (VEN-AZA) Vs. Intensive Chemotherapy (IC) As Induction for Patients with Acute Myeloid Leukemia (AML): Retrospective Analysis of an Electronic Medical Records (EMR) Database in the United States
Authors: Amer M. Zeidan, Daniel A. Pollyea, Uma Borate, Alberto Vasconcelos, Ravi Potluri, David Rotter, Zephirin Kiendrebeogo, Lona Gaugler, Gaetano Bonifacio, Clara Chen
Journal: Blood (2021)
Immunotherapeutic Targeting of TSLPR with Chimeric Antigen Receptor T Cells in AML
Authors: Lindsey F Call, Sommer Castro, Thao T. Tang, Cynthia Nourigat-Mckay, LaKeisha Perkins, Laura Pardo, Amanda R. Leonti, Soheil Meshinchi, Quy Le
Journal: Blood (2021)
Outcomes with Hematopoietic Stem Cell Transplantation in Secondary Hemophagocytic Lymphohistiocytosis: A Systematic Review and Meta-Analysis
Authors: Qamar Iqbal, Moazzam Shahzad, Ezza Tariq, Laila Hashim, Abdul Basit, Kashf Zaidi, Muhammad Salman Faisal, Iqra Anwar, Sibgha Gull Chaudhary, Ramesh Balusu, Nausheen Ahmed, Leyla Shune, Peiman Hematti, Joseph P. McGuirk, Muhammad Umair Mushtaq
Journal: Blood (2021)
Safety and Anti-Tumor Activity of Plamotamab (XmAb13676), an Anti-CD20 x Anti-CD3 Bispecific Antibody, in Subjects with Relapsed/Refractory Non-Hodgkin's Lymphoma
Authors: Krish Patel, Jean-Marie Michot, Asher Chanan-Khan, Herve Ghesquieres, Kamal Bouabdallah, John C. Byrd, Guillaume Cartron, Craig A. Portell, Melhem Solh, Hervé Tilly, William G. Wierda, Patricia McGovern, Chelsea Johnson, Raman Garcha, Vincent Ribrag, Gabriel Brisou, David Liebowitz, Tycel Phillips
Journal: Blood (2021)
Engraftment Kinetics and Recipient Chimerism Increase to Predict Leukemia Relapse By Ptcy and Non-Ptcy Transplant
Authors: Ruoheng Zhang, Kevin L Rakszawski, Myles Nickolich, W. Christopher Ehmann, Baldeep Wirk, Seema G Naik, Witold B. Rybka, Hong Zheng, Joseph Mierski, Brooke Silar, Gina Mackey, Jason Liao, Shouhao Zhou, Robert Greiner, Valerie Brown, David F. Claxton, Shin Mineishi, Hiroko Shike, Kentaro Minagawa
Journal: Blood (2021)
Serum Proteomic Analyses Suggest That the HMGB1 and Other Inflammatory Pathways Are Operational in MBL and Are Less in Overt CLL
Authors: Florencia Palacios, Gonzalo Blanco, Kamala Vanarsa, Poojitha Dugyala, Steven L Allen, Yasmine Kieso, Anna Puiggros, Jacqueline Barrientos, Xavier Calvo, Jonathan E Kolitz, Eva Gimeno, Joanna M Rhodes, ANA Ferrer, Kanti R Rai, Blanca Espinet, Chandra Mohan, Nicholas Chiorazzi
Journal: Blood (2021)
Frequency, Histologic, and Prognostic Significance of CD30 Expression in AIDS-associated Diffuse Large B-Cell Lymphoma
Authors: Amina Chaudhry, Muhammad Junaid Tariq, Eshana Shah, Camille E. DeMarco, Erin G. Reid, Ethel Cesarman, Amy Chadburn, Paul Rubinstein
Journal: Blood (2021)
A Phase 1 Study Evaluating ASTX727 (decitabine and cedazuridine) and Venetoclax Combination Therapy in Newly Diagnosed AML Patients Unfit for Intensive Induction Chemotherapy
Authors: Gabriel N. Mannis, Elizabeth A. Griffiths, Michael R. Savona, Olatoyosi Odenike, Gail J. Roboz, Casey L. O'Connell, Jacqueline Dillingham, Prieya Wason, Lixia Zhu, Danna Chan, Harold N. Keer, Aram Oganesian, Kim-Hien Dao, Courtney D. DiNardo
Journal: Blood (2021)
Abstract 9458: Nutritional Status Determines Early versus Late Deaths in Patients With Heart Failure With Preserved Ejection Fraction -Insights from the PURSUIT-HFPEF Registry-
Authors: Masato Okada, Nobuaki Tanaka, Toshinari Onishi, Katsuomi Iwakura, Masahiro Seo, Masamichi Yano, Takaharu Hayashi, Nakagawa Akito, Yusuke Nakagawa, Shunsuke Tamaki, Takahisa Yamada, Yoshio Yasumura, Yohei Sotomi, Shungo Hikoso, Yasushi Sakata
Journal: Circulation (2021)

Introduction: Understanding how patients with heart failure with preserved ejection fraction (HFpEF) die provides insight into the natural history and pathophysiology of this complex syndrome. Factors that influence early death might identify potentially modifiable risk factors that could improve the long-term outcomes Objectives: To investigate whether early and late death are associated with different baseline factors in HFpEF patients. Methods: An analysis was performed from a prospective multicenter observational registry for HFpEF (PURSUIT-HFpEF Registry) conducted in the Osaka region of Japan. A total of 1095 patients hospitalized for acute HF (diagnosed by using Framingham criteria) met the inclusion criteria: a left ventricular ejection fraction (LVEF) ≥50% and brain natriuretic peptide ≥100 pg/ml. We included 195 patients (age, 85±7 years; females, 52%; atrial fibrillation, 43%) who died after a survival discharge. Early and late deaths were defined as deaths within and over 1 year after discharge, respectively. Results: During the median survival period of 11.8 months (IQR, 5.2-24.8), 98 and 97 patients died within and over 1 year, respectively. Patients with early death were older (86±7 vs. 84±7 years, p=0.010) and had a poorer nutritional status (i.e., higher Controlling Nutritional Status [CONUT] score: 5.3±2.3 vs. 4.0±2.3, p &lt;0.001) than those with late death. However, there was no difference in the prevalence of a female gender and the body mass index and LVEF. The cause of death did not differ between early and late deaths. Almost two thirds of deaths were from non-cardiovascular causes. After adjustment for age, gender, body mass index, and LVEF, logistic regression analysis revealed that the CONUT score of &gt;3, above the optimal cut-off value of the score, was the only determinant to predict early death (hazard ratio 2.60, 95% confidence interval 1.20-5.65). Conclusions: A considerable number of patients with HFpEF died within 1 year after discharge. Poor nutritional status determined the early death in HFpEF patients.
Single-Cell Clonal Tracking in Allogeneic Hematopoietic Stem Cell Transplantation Reveals Time Dependent and Distinct Functional Patterns in Traceable Donor T Cell Clones
Authors: Friedrich Wittenbecher, Luisa Keilholz, Benedikt Obermayer, Thomas Conrad, Marco Frentsch, Igor Wolfgang Blau, Lam Giang Vuong, Franziska Borchert, Stella Lesch, Kamran Movasshagi, Carola Tietze-Bürger, Olaf Penack, Johann Ahn, Dieter Beule, Lars Bullinger, Il-Kang Na
Journal: Blood (2021)
Abstract 9848: Image Guided Computational Model of the Mitral Valve in Heart Failure with Functional Mitral Regurgitation - A Platform for Preclinical Procedure Planning
Authors: Gediminas Gaidulis, Muralidhar Padala
Journal: Circulation (2021)

Introduction: Therapeutic benefit of correcting functional mitral regurgitation (FMR) is increasingly recognized, since positive results from COAPT trial indicate a significant reduction in hospitalization rate and mortality. However, this benefit is strongly dependent on the extent of reduction in FMR with the MitraClip system, which is often variable and unpredictable. We report a patient-specific, 3D echo derived computational model of the mitral valve that faithfully mimics the FMR-like valve for procedure planning. Methods: FMR datasets were obtained in two pigs that received a myocardial infarction via percutaneous occlusion of the left circumflex artery. 3D echo was performed 3 months after infarction, and images were segmented to obtain annular and leaflet geometry, and papillary muscle (PM) locations in the ventricle. Chordal distribution was developed (Fig. A) based on anatomical measurements in hearts as they are not visible on echo. The PMs were sub-divided into three heads with marginal, strut and basal chordae emerging from these heads as seen in real hearts (Fig. B) . In FMR state, the PM locations are displaced, imposing a pre-strain on the chordae. Valve closure simulation was modeled by pre-straining the chordae and applying transvalvular pressure gradient on the leaflets, and stress analysis was performed. Results: Agreement in the truth dataset (echo image) and the model (simulated data) are shown in Fig. C , indicating fidelity of the model. Peak stresses were observed on A2 and P2 segments near the strut chordae insertion regions with maximum values of 7.62 and 4.93 MPa for each dataset (Fig. D) , which corresponds well with the previously reported findings. Conclusions: A proposed FMR modeling workflow allowed to obtain a realistic systolic configuration of the mitral valve. Such models may be used to virtually implement various FMR repair techniques, allowing to predict post-repair outcomes and optimize FMR repair at a patient-specific level.
Eomes and T-Bet Expression Are Required By Mature Primary Human NK Cells for Anti-Leukemia Responses In Vivo
Authors: Pamela Wong, Carly C. Neal, Lily Chang, Julia A Wagner, Melissa M. Berrien-Elliott, Celia C. Cubitt, Jennifer Tran, David A. Russler-Germain, Nancy D. Marin, Jennifer A Foltz-Stringfellow, Lynne Marsala, Timothy Schappe, Todd A. Fehniger
Journal: Blood (2021)
Bypass of dG-AAF in the Y-family Dpo4 polymerase: Molecular dynamics studies.
Authors: Lihua Wang, Robert Shapiro, Suse Broyde
Journal: Cancer Research (2006)

5239  Primer extension studies have shown that the Y-family DNA polymerase Dpo4 can bypass the dG-AAF adduct with preferential incorporation of normal partner C, followed by mismatched A [Boudsocq et al. (2001) Nucleic Acids Res. 29:4607]. This polymerase contains major and minor groove pockets that may accommodate a bulky adduct. The major groove pocket is much more spacious and open. Decades of studies have indicated that dG-AAF favors the syn glycosidic torsion conformation. However, this conformation precludes Watson-Crick base-pairing in B-DNA, presenting a challenge to the polymerase in selection of the complementary incoming nucleotide, and in accommodating a C8 substituted bulky adduct which then would be placed in the small minor groove pocket. Our goal in the current study is to elucidate on a structural level how dG-AAF can be harbored in the Dpo4 DNA polymerase active site opposite an incoming dCTP or dATP, using molecular modeling and molecular dynamics simulations. Both anti and syn conformations of the templating dG-AAF in Dpo4 were investigated, employing a Type I Dpo4 ternary complex crystal structure [Ling et al., (2004) Proc. Natl. Acad. Sci.U.S.A. 101:2265] as initial model. We found that a structure with unusual anti glycosidic torsion and C1’-exo deoxyribose conformation allows dG-AAF to be Watson-Crick hydrogen-bonded with dCTP, or form two hydrogen bonds with an incoming syn dATP. In these structures, the fluorenyl rings of dG-AAF are comfortably situated in the Dpo4 large major groove open pocket. With dG-AAF syn, the fluorenyl rings are in the small minor groove pocket and the active site region is highly distorted. Thus, flexibilities inherent in DNA structure can be utilized by the Dpo4 DNA polymerase to facilitate bypass of a bulky adduct. The novel anti AAF-dG conformation can explain the preferential incorporation of dC and dA by Dpo4, and also may be relevant to observed dCTP incorporation opposite AAF-dG in other polymerases. This work is supported by NIH 2R01 CA75449.
Two-Year Follow-up of Keynote-087 Study: Pembrolizumab Monotherapy in Relapsed/Refractory Classic Hodgkin Lymphoma
Authors: Pier Luigi Zinzani, Robert W. Chen, Hun Ju Lee, Philippe Armand, Nathalie A Johnson, Pauline Brice, John Radford, Vincent Ribrag, Daniel Molin, Theodoros P. Vassilakopoulos, Akihiro Tomita, Bastian Von Tresckow, Margaret A. Shipp, Eunhee Kim, Akash Nahar, Arun Balakumaran, Craig H. Moskowitz
Journal: Blood (2018)
Abstract 6991: Impaired Systemic Oxygen Extraction Relates to Reduced Exercise Capacity in Post-COVID-19 Long Hauler Syndrome
Authors: Max J Biondi, Phillip Joseph, Mridu Gulati, Jennifer Possick, Denyse Lutchmansingh, Marjorie Cullinan, Paul M Heerdt, Inderjit Singh
Journal: Circulation (2021)

Introduction: Following acute coronavirus 2019 (COVID-19) disease, at least 10% of patients report some form of residual limitation, most commonly dyspnea and fatigue. These COVID-19 “long haulers” experience symptoms that are largely unexplained by pulmonary function testing (PFT), echocardiogram and chest computed tomography (CT). Using invasive cardiopulmonary exercise testing, this pilot study characterized exercise limitation in 5 patients with persistent symptoms 1 year following mild COVID-19 illness. Methods: Following written informed consent, data were obtained in accordance with an IRB-approved protocol entailing placement of radial and pulmonary arterial catheters for pressure monitoring and blood sampling prior to and during maximum upright incremental exercise. Rest and exercise pulmonary hemodynamics, ventilation and gas exchange were recorded. Aerobic exercise capacity was estimated by peak O 2 consumption (VO 2 ). Results: All patients had normal biventricular and valvular function on resting echocardiogram, no evident parenchymal lung disease on CT, and normal PFTs. Resting mean pulmonary arterial pressure was ≤20 mmHg for all patients with pulmonary vascular resistance &lt;3 Woods units. At maximum exercise, all patients exhibited normal respiratory, cardiac output (% predicted), and total pulmonary vascular resistance responses, but demonstrated clearly depressed aerobic capacity (peak VO 2 &lt;80% predicted). Reduced peak VO 2 was associated with impaired systemic O 2 extraction as indicated by an arterial-venous O 2 content difference (adjusted for hemoglobin) of &lt;80% ( Figure 1 ). Conclusion: This case series provides preliminary evidence that reduced peak aerobic capacity among long haulers is primarily attributable to a peripheral (i.e., impaired systemic O 2 extraction), rather than central cardiopulmonary, limitation. These results suggest that systemic microcirculatory dysfunction contributes to exercise limitation.
過剰運動スペクトル障害または過可動性Ehlers-Danlos症候群患者におけるローマIV機能性胃腸障害と健康障害【JST・京大機械翻訳】
Authors: Y Lam Ching, S Palsson Olafur, E Whitehead William, D Sperber Ami, Tornblom Hans, Simren Magnus, Aziz Imran
Journal: Clinical Gastroenterology and Hepatology (2021)
Abstract 9420: A Striking Contrast Between Lipid Therapy Prescribing Patterns versus Achieving Optimal Lipid Levels in Black and Hispanic Populations Following Acute Coronary Events
Authors: Maxwell Ambrosino, Sydney Emerson, Patricia Hernandez, Douglas Jacoby
Journal: Circulation (2021)

Introduction: Guideline directed lipid therapy (GDLT) for patients following acute coronary syndrome (ACS) is well-established secondary prevention. Historically disparities in secondary prevention have been observed among minority populations, however there is limited understanding of GDLT and resultant impact on achieving optimal LDL levels. Hypothesis: GDLT may not proportionally result in achievement of LDL &lt;70 mg/dL. Methods: A cross-sectional study was employed across all University of Pennsylvania Health System from 2018 to 2019. Electronic medical records were queried for all admitted patients diagnosed with ACS. Data was collected for age, gender, race, GDLT, and lipid profiles up to 1-year post-discharge. Results: We identified 3386 patients with whom 2264 (66.8%) were male and 1122 (33.1%) were female. The majority was white representing 63.5% (2152), followed by 21.2% (718) Black, &lt;4% (119) Asian, &lt;3% (89) Hispanic, &lt;2% (50) East Indian, and &lt;1% (7) American Indian. At discharge 75.23% of White patients, 82.60% of Black patients, and 85.80% of Hispanic patients were prescribed GDLT. Non-statin therapy (including Ezetimibe and PCSK9-inhibitors) were prescribed post-discharge to 13.38% White patients, 12.26% Black patients, and 12.76% Hispanic patients. The rate of achieving optimal LDL was 53.89% in White patients, 41.07% in Black patients, and 44.40% in Hispanic patients. Conclusions: Black and Hispanic groups were prescribed GDLT at a greater rate than the White population. Despite this, less than 50% of Black and Hispanic groups achieved optimal LDL levels, about 10% less than the White population. Furthermore, non-statin therapy was prescribed slightly less than the White population. We observed disparities among racial groups in achieving optimal LDL levels despite being prescribed GDLT at a higher rate. Future investigation and a holistic approach to existing racial disparities will allow for improved secondary prevention.
Efanesoctocog Alfa Half-Life and Clearance Are Independent of von Willebrand Factor in Severe Hemophilia A: A Post Hoc Analysis from Phase 1/2a Studies
Authors: Janice M. Staber, Toshko Lissitchkov, Barbara A. Konkle, Amy D. Shapiro, Doris V. Quon, Roshni Kulkarni, Melinda Hamilton, Ekta Seth Chhabra, Suresh Katragadda, Arman Altincatal, Annemieke Willemze, Jennifer Dumont, Margaret V. Ragni
Journal: Blood (2021)
Systematic Omission of Pregnant and Lactating Women from Malignant Haematology Trials Perpetuates a Cycle of Exclusion, Data Shortage and Disadvantage
Authors: Georgia Mills, Catherine Tang, Pietro R Di Ciaccio, Verity L Chadwick, Barbara Withers, Orly Lavee, Sam Milliken, Jacinta Perram, Georgia J McCaughan, Nada Hamad
Journal: Blood (2021)
Imaging Biomarkers to Predict Outcomes in Patients with Large B-Cell Lymphoma with a Day 28 Partial Response By PET/CT Imaging Following CAR-T Therapy
Authors: Forat Lutfi, Olga Goloubeva, Dong Won Kim, Amer Kowatli, Anton Gryaznov, Philip Margiotta, Lisa R Matsumoto, David Gottlieb, Ali Bukhari, Caroline Dunne, Jennie Y. Law, Seung-Tae Lee, Kathleen Ruehle, Jean A. Yared, Mehmet Hakan Kocoglu, Djordje Atanackovic, Nancy M. Hardy, Wengen Chen, Aaron P. Rapoport, Saurabh Dahiya
Journal: Blood (2021)
Inhibition of Pre-BCR Signaling Mediates a Metabolic Switch in B-Cell Progenitor Acute Lymphoblastic Leukemia
Authors: Yuxuan Liu, Lucille Stuani, Dorra Jedoui, Milton Merchant, Astraea Jager, Jolanda Sarno, Charles G. Mullighan, Felix J. Hartmann, Sean Bendall, Kara L. Davis
Journal: Blood (2021)
The Presence of <i>SETBP1</i>, <i>RUNX1</i> or <i>EZH2</i> Mutation in MDS/MPN Is Associated with Absence of Response to Hypo-Methylating Agents
Authors: Theodoros Karantanos, Hua-Ling Tsai, Mark Levis, Ravi Varadhan, Richard J. Jones, Tania Jain
Journal: Blood (2021)