tbuckley/cabot-search huggingface dataset:
Sex differences in proteomic correlates of coronary microvascular dysfunction among patients with heart failure and preserved ejection fraction
Authors: Chanchal Chandramouli, Tay W. Ting, Jasper Tromp, Anubha Agarwal, Sara Svedlund, Antti Saraste, Camilla Hage, Ru‐San Tan, Lauren Beussink‐Nelson, Maria Lagerström Fermer, Li‐Ming Gan, Lars Lund, Sanjiv J. Shah, Carolyn S.P. Lam
Journal: European Journal of Heart Failure (2022)

Little information is available on sex differences in coronary microvascular dysfunction (CMD) in heart failure with preserved ejection fraction (HFpEF). We investigated sex-specific proteomic profiles associated with CMD in patients with HFpEF.
Engineered extracellular vesicle-based sonotheranostics for dual stimuli-sensitive drug release and photoacoustic imaging-guided chemo-sonodynamic cancer therapy
Authors: Thuy Giang Nguyen Cao, Ji Hee Kang, Wangyu Kim, Junha Lim, Su Jin Kang, Jae Young You, Quan Truong Hoang, Won Jong Kim, Won Jong Rhee, Chulhong Kim, Young Tag Ko, Min Suk Shim
Journal: Theranostics (2022)

Sonodynamic therapy has shown promise as an effective alternative to conventional photodynamic therapy owing to its ability to treat deep-seated tumors.However, the development of stimuli-responsive sonosensitizers with high biocompatibility faces a significant challenge.Methods: In this study, we developed dual stimuli-responsive sonosensitizers with desirable biosafety using extracellular vesicles (EVs), a class of naturally occurring nanoparticles.Indocyanine green (ICG), which functions as both a sonosensitizer and photoacoustic (PA) imaging agent, was loaded into EVs, together with paclitaxel (PTX) and sodium bicarbonate (SBC), to achieve pH-responsive PA imaging-guided chemo-sonodynamic combination therapy.Results: The EVs significantly improved the cellular uptake of ICG, thus triggering enhanced sonodynamic effects in breast cancer cells.SBC-, ICG-, and PTX-loaded EV [SBC-EV(ICG/PTX)] efficiently released the PTX in response to acidic pH in the endo/lysosomes because CO2 bubbles generated from the SBC caused the EV membranes to burst.The drug release was further facilitated by ultrasound (US) treatment, demonstrating dual pH/US-responsive drug release.The ICG-and PTX-loaded EVs exhibited efficient anticancer activity against breast tumor cells owing to the combination of chemo-sonodynamic therapy.High-resolution PA imaging visualized the preferential tumor accumulation of SBC-EV(ICG/PTX) in tumor-bearing mice.Notably, a single intravenous injection of SBC-EV(ICG/PTX) with US irradiation significantly suppressed tumor growth in mice without systemic toxicity.Conclusions: Our findings demonstrate that dual stimuli-responsive SBC-EV(ICG/PTX) are promising sonotheranostic nanoplatforms for safe and efficient chemo-sonodynamic combination cancer therapy and photoacoustic imaging.
Harnessing Bifunctional Ferritin with Kartogenin Loading for Mesenchymal Stem Cell Capture and Enhancing Chondrogenesis in Cartilage Regeneration
Authors: En Ren, Haimin Chen, Zainen Qin, Siwen Guan, Lai Jiang, Xin Pang, Yi He, Yang Zhang, Xing Gao, Chengchao Chu, Li Zheng, Gang Liu
Journal: Advanced Healthcare Materials (2022)

Methods that leverage bone marrow mesenchymal stem cells (BMSCs) and stimulating factor kartogenin (KGN) for chondrocyte differentiation have paved the way for cartilage repair. However, the scarce carriers for efficiently bridging the two components significantly impede their further application. Therefore, one kind of bifunctional ferritin has designed and synthesized: RC-Fn, a genetically engineered ferritin nanocage with RGD peptide and WYRGRL peptide on the surface. The RGD can target the integrin αvβ3 of BMSCs and promote proliferation, and the WYRGRL peptide has an inherent affinity for the cartilage matrix component of collagen II protein. RC-Fn nanocages have an ideal size for penetrating the proteoglycan network of cartilage. Thus, intra-articularly injected RC-Fn with KGN loading can convert the articular cavity from a barrier into a reservoir to prevent rapid release and clearance of KGN and exogenous BMSCs, which results in efficient and persistent chondrogenesis in cartilage regeneration.
Myocardial contrast echocardiography in conjuction with dipyridamole thallium SPECT in assessing myocardial perfusion in patients with suspected coronary artery disease Miguel Zabalgoitia, John Erikson, Mohamed A. Oraby, Albert Delgado. University of Texas Health Science Center, San Antonio, TX, Audie L Murphy Memorial Veterans Hospital, San Antonio, TX
Journal: Journal of the American College of Cardiology (2001)
Liver stromal cells restrict macrophage maturation and stromal IL-6 limits the differentiation of cirrhosis-linked macrophages
Authors: Erica L. Buonomo, Shenglin Mei, Samantha R. Guinn, Isabelle R. Leo, Michael J. Peluso, Mei-An Nolan, Frank A. Schildberg, Lei Zhao, Christine Lian, Shuyun Xu, Joseph Misdraji, Peter V. Kharchenko, Arlene H. Sharpe
Journal: Journal of Hepatology (2022)
Current Comment
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Outcomes after first relapse of children with intracranial ependymoma treated on the second l’Associazione Italiana di Ematologia e Oncologia Pediatrica (AIEOP) protocol
Authors: Nicholas K Foreman
Journal: Neuro-Oncology (2021)

A new paper1 from this Italian group in the current issue of Neuro-Oncology looks at the 64 children who had a first relapse out of the 160 originally treated on the previously published 2nd AIEOP protocol.2 Of these 64 discussed in the current paper,1 there were only 17 surviving at a median follow-up of 84-month post-relapse. This confirms the poor overall prognosis post-first relapse in childhood ependymoma seen by others.3,4 The paper1 selects for further analysis a cohort of 55 of these 64 children, excluding 4 who received no therapy at relapse and 5 with both tumor at the primary site and metastatic disease at relapse. This cohort of 55 children1 had 5-year EFS (event-free survival)/OS (overall survival) rates of 26.2%/30.8%, suggesting a potential for salvage in a minority, although potential for recurrence remains even after 5 years. This is a predominantly male cohort with 44 males and only 11 females, reflecting not only a male predominance in ependymoma2 but also a higher relapse rate in males compared to females.1 In the detailed analysis girls had a significantly favorable prognosis compared to boys, but only if they were asymptomatic at relapse. Girls presenting with symptoms did very badly.
References and Reviews
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Interaction of Blood Lead and d-Aminolevulinic Acid Dehydratase Genotype on Markers of Heme Synthesis and Sperm Production in Lead Smelter Workers
Authors: Bruce H. Alexander, Harvey Checkoway, Paola Costa-Mallen, Elaine M. Faustman, James S. Woods, Karl T. Kelsey, Chris van Netten, Lucio G. Costa
Journal: Environmental Health Perspectives (1998)
Transplantable Sarcomas Induced in Rats by &lt;italic&gt;N,N&lt;/italic&gt;-Dimethyl-&lt;italic&gt;p&lt;/italic&gt;-(l-naphthylazo)aniline
Authors: A. S. Mulay, R. W. O'Gara
Journal: JNCI Journal of the National Cancer Institute (1957)

Transplantable Sarcomas Induced in Rats by N,N-Dimethyl-p-(l-naphthylazo)aniline A. S. Mulay, A. S. Mulay National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar R. W. O'Gara R. W. O'Gara National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 18, Issue 6, June 1957, Pages 843–855, https://doi.org/10.1093/jnci/18.6.843 Published: 01 June 1957 Article history Received: 05 March 1957 Published: 01 June 1957
Foreshadowing Diabetes
Authors: Joan Stephenson
Journal: JAMA (2009)

Changes in blood glucose and insulin sensitivity are evident several years before a patient is diagnosed with type 2 diabetes, according to findings from a team of European researchers (Tabák AG et al. Lancet. doi:10.1016/S0140-6736(09)60619-X [published online ahead of print June 8, 2009]).
Weight-based dosing of thrombolysis: How well do we estimate weight? How often would this translate into errors with administration of thrombolytic drugs? A comparison of single-bolus TNK with t-PA in TIMI B Christopher P. Cannon, Michael Gibson, Sabina A. Murphy, Frans Van de Werf, Carolyn H. McCabe. Brigham and Women's Hospital, Boston, MA
Journal: Journal of the American College of Cardiology (2001)
Abstract 457: Comparison of Effect of Audio-Instructed and Video-Instructed Dispatcher-Assisted Cardiopulmonary Resuscitation on Resuscitation Outcomes After Out-Of-Hospital Cardiac Arrest
Authors: Sun Young Lee, Kyoung Jun Song, Sang Do Shin, Ki Jeong Hong, Kim Jong Hwan, Jieun Pak
Journal: Circulation (2019)

Introduction: This study aimed to compare the effect of audio-instructed dispatcher-assisted cardiopulmonary resuscitation (DA-CPR) and video-instructed DA-CPR on resuscitation outcome after out-of-hospital cardiac arrest (OHCA) in the real world. Methods: A cross-sectional study was conducted for resuscitation-attempted adult OHCAs of 2017 in Seoul, Korea. Seoul implemented video-instructed DA-CPR program in 2017. According to the protocol, when dispatcher detected OHCA, they checked two condition: 1) more than two bystanders were in the scene, 2) they could handle a video-call. If both conditions were met, dispatcher initiated the CPR instruction and called back a video-call to the caller for instructing CPR via video (video group). Unless, standard audio-instructed DA-CPR was provided (audio group). The primary outcome was survival to discharge. The secondary outcome was good neurological outcome at hospital discharge. The tertiary outcome was early instruction time interval (ITI, time from call to the initiation of CPR instruction≤ 90 seconds). The study outcomes were compared between audio and video group. A multivariable logistic regression analysis was performed and adjusted odds ratios (AORs) with 95% confidence intervals (CIs) were calculated adjusting for potential confounders. Propensity score matching (PSM) method was used to increase comparability of two groups and same logistic regression model was analyzed for the PSM population. Results: A total of 1,720 eligible OHCA cases (1,489 in audio and 231 in video group) were evaluated. The median seconds of ITI was 136 seconds in audio group and 122 seconds in the video group (p=0.12). Survival to discharge was 8.9% in audio group and 14.3% in video group (p&lt;0.01). Good neurological outcome was 5.8% in audio group and 10.4% in video group (p&lt;0.01). Compared with audio group, the AORs (95% CIs) for survival to discharge, good neurological outcome and early ITI of the video group were 1.20 (0.74 to 1.94), 1.28 (0.73 to 2.26) and 1.00 (0.70 t0 1.43), respectively. PSM population showed similar results with original population. Conclusion: Compared with audio-instructed DA-CPR, video-instructed DA-CPR was not associated with survival improvement in the observational study.
RETROPHARYNGEAL ABSCESS
Authors: Muhammad Asghar
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chirurg, Berlin
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of early postoperative shear stress on late postoperative remodeling of aortocoronary bypass graft Hiroshi Sato, Masao Okamura, Takeyoshi Ohta, Keiji Kurogane, Ryouhei Kuroda, Takashi Kajiura. Takatsuki General Hospital, Takatsuki-city, Japan
Journal: Journal of the American College of Cardiology (2001)
Systems-level conservation of the proximal TCR signaling network of mice and humans
Authors: Philippe Nicolas, Jocelyn Ollier, Daiki Mori, Guillaume Voisinne, Javier Celis-Gutierrez, Claude Gregoire, Jeanne Perroteau, Régine Vivien, Mylène Camus, Odile Burlet-Schiltz, Anne Gonzalez de Peredo, Béatrice Clémenceau, Romain Roncagalli, Henri Vié, Bernard Malissen
Journal: The Journal of Experimental Medicine (2022)

We exploited traceable gene tagging in primary human T cells to establish the composition and dynamics of seven canonical TCR-induced protein signaling complexes (signalosomes) using affinity purification coupled with mass spectrometry (AP-MS). It unveiled how the LAT adaptor assembles higher-order molecular condensates and revealed that the proximal TCR-signaling network has a high degree of qualitative and quantitative conservation between human CD4+ and CD8+ T cells. Such systems-level conservation also extended across human and mouse T cells and unexpectedly encompassed protein–protein interaction stoichiometry. Independently of evolutionary considerations, our study suggests that a drug targeting the proximal TCR signaling network should behave similarly when applied to human and mouse T cells. However, considering that signaling differences likely exist between the distal TCR-signaling pathway of human and mouse, our fast-track AP-MS approach should be favored to determine the mechanism of action of drugs targeting human T cell activation. An opportunity is illustrated here using an inhibitor of the LCK protein tyrosine kinase as a proof-of-concept.
Correlation of circulating tumor DNA (ctDNA) with clinical outcomes in appendiceal cancers (AC).
Authors: Vishesh Kothary, Oliver Eng, Blase N. Polite, Chih-Yi Liao, Daniel V.T. Catenacci, Ankit Dhiman, Kiran Turaga, Ardaman Shergill
Journal: Journal of Clinical Oncology (2022)

29 Background: Appendiceal Cancers are a heterogenous group of rare tumors with distinct histopathologic and genomic alterations. These often have peritoneal spread that might not be easily detected on current imaging modalities, and conventional tumor markers may not lend diagnostic support. Hence, novel diagnostic techniques are needed. Measurement of ctDNA for recurrence risk prediction, response to therapy and and early diagnosis is a promising technique. However, limited published data exist in AC to validate the role and utility of ctDNA in clinical practice. Here we present a single institution experience of ctDNA analysis in patients with AC. Methods: ctDNA measurements of 37 pts with stage II-IV AC treated between 1/1/2019 and 9/15/2021 were reviewed retrospectively. ctDNA analysis was done using Signatera bespoke mPCR NGS assay. ctDNA results were compared to crossectional imaging, CEA levels, and clinical evaluation. Results: 19/37 patients (51%) had at least one positive ctDNA test result. Of those, 8 had testing done during the surveillance setting (two with grade 3, one with grade 2, two with grade 1, and three with unknown grade). Of those, 5 pts (62.5%) had positive ctDNA detected, while 33.33% had elevated CEA level, 25% had radiographic and 42.9% had clinical evidence of recurrence (Table). 7/14 (50%) pts had high-grade pathology and positive ct-DNA, 3/6 (50%) patients had low-grade (grade 1) pathology and positive ct-DNA findings. 4 patients had longitudinal ct-DNA measurements available which correlated well with their disease course. Median duration to recurrence (radiographic or laparoscopic) was 376 days. Median duration to the first positive ctDNA test was 370 days. Median duration to positive CEA after initial treatment was 475 days. Conclusions: Measurement of ctDNA can be a useful tool to follow disease course and to guide management decision-making in patients with AC. Prospective studies with serial measurements of ctDNA are planned. [Table: see text]
Abstract P339: Volunteering and Favorable Cardiovascular Health in Hispanic/Latinos: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Sociocultural Ancillary Study
Authors: Mayra L Estrella, Ramon A Durazo, Michele A Kelley, Linda C Gallo, Aida L Giachello, Krista M Perreira, Carmen R Isasi, Earle C Chambers, Donglin Zeng, Violeta Carrion, James P Lash, Martha L Daviglus
Journal: Circulation (2017)

Introduction: Volunteering - a social capital indicator - has been associated with a lower burden of CVD risk factors in middle-aged and older adults . The prevalence of volunteering and its association with favorable cardiovascular health (i.e., low CV risk, LR ) has not been examined among diverse Hispanic/Latino adults. Hypothesis: Volunteering is positively associated with LR independent of sociodemographic and lifestyle factors; this association is modified by acculturation. Methods: Our analysis included 4,385 participants, ages 18-74 years, from the HCHS/SOL Sociocultural Ancillary Study (2010-2011), a population-based cohort of US Hispanics/Latinos. Multivariate logistic regression (survey weighted) was used to examine cross-sectional associations of self-reported current regular volunteering (yes vs. no) with LR (definition in Table). We tested whether these associations varied by acculturation (assessed as language preference [English vs. Spanish] and length of residence in the US [&lt;10 vs.≥10 years]). Results: The prevalence of regular volunteering was 15.4%. Volunteers were more likely to be English speakers, have lived in the US ≥10 years, and had higher income and education than non-volunteers.Association of volunteering with LR varied by length of residence in the US but not with language preference (P for interactions=0.06 and 0.77, respectively). Among persons with ≥10 years of residence in the US, volunteering was associated with more than 2 times higher odds of being at LR vs. non-volunteering in the fully adjusted model (Table). No association of volunteering with LR was observed among those living in the US &lt;10 years. Conclusions: Volunteering was associated with LR among Hispanic/Latino adults who have lived in the US for ≥10 years independent of sociodemographic and lifestyle factors. Future research should examine the mechanisms underlying this association, as well as the longitudinal associations of volunteering with incidence of CVD risk factors to assess reverse causality.
Selected New Books
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal