tbuckley/cabot-search huggingface dataset:
Results at Age 8 Years of Early Intervention for Low-Birth-Weight Premature Infants
Authors: Cecelia M. McCarton
Journal: JAMA (1997)

<h3>Objective.</h3> —To reevaluate at age 8 years children who had participated during the first 3 years of life in a randomized clinical trial of special services for low-birthweight (LBW) premature infants. <h3>Design.</h3> —Follow-up of a randomized controlled trial of premature infants (&lt;37 weeks' gestation), stratified by 2 LBW groups (lighter [&lt;2000 g] and heavier [2001 2500 g]) and divided into intervention (n=377) and follow-up only (n=608) groups. <h3>Setting.</h3> —Eight sites serving diverse populations. <h3>Participants.</h3> —At age 8 years, 874 children were assessed: 336 in the intervention group and 538 in the follow-up only group. <h3>Intervention.</h3> —The 3-year intervention consisted of home visits (birth to 3 years), child development center services (ages 1 to 3 years), and parent group meetings (ages 1 to 3 years). <h3>Primary Outcome Measures.</h3> —Cognitive functioning (Weschler Intelligence Scale for Children-Ill; Peabody Picture Vocabulary Test-Revised); academic achievement (Woodcock-Johnson Tests of Achievement-Revised); and parental reports of school performance, behavior (Child Behavior Checklist), and health (Child General Health Survey). <h3>Results.</h3> —At age 8 years, in the entire cohort and in the lighter LBW stratum, the intervention and follow-up only groups were similar on all primary outcome measures. Differences favoring the intervention group were found within the heavier LBW group: full-scale IQ score (4.4 points higher,<i>P</i>=.007), verbal IQ score (4.2 points higher,<i>P</i>=.01 ), performance IQ score (3.9 points higher,<i>P</i>=.02), mathematics achievement score (4.8 points higher,<i>P</i>=.04), and receptive vocabulary score (6.7 points higher,<i>P</i>=.001 ). On a physical functioning subscale, the whole intervention group received less favorable ratings, while the lighter LBW intervention group had lower maternal ratings assessing social limitations caused by behavior. <h3>Conclusion.</h3> —Although at age 8 years there were modest intervention-related differences in the cognitive and academic skills of heavier LBW premature children, attenuation of the large favorable effects seen at 3 years was observed in both the heavier and lighter LBW groups. This indicates a need to develop additional intervention strategies for LBW premature children that can provide sustained benefits.
My Breast: One Woman's Cancer Story
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reengineering GME in a Pandemic — Looking Back, and Forward
Authors: Debra F. Weinstein
Journal: New England Journal of Medicine (2022)

Interview with Dr. Debra Weinstein on the pandemic's effects on graduate medical education and what we can learn from them. (12:35)Download Both the challenges and bright spots of Covid's impact on graduate medical education provide important lessons. We can mine lessons learned during this crisis to better protect trainees and their education during future emergencies and to improve GME overall.
Socioeconomic Factors Play a More Important Role than Clinical Needs in the Use of SGLT2 Inhibitors and GLP-1 Receptor Agonists in People With Type 2 Diabetes
Authors: Hui Shao, Piaopiao Li, Jingchuan Guo, Vivian Fonseca, Lizheng Shi, Ping Zhang
Journal: Diabetes Care (2022)
Primary Treatment of Light Chain (AL) Amyloidosis with Bortezomib, Lenalidomide and Dexamethasone (VRD)
Authors: Eftathios Kastritis, Ioanna Dialoupi, Maria Gavriatopoulou, Maria Roussou, Nikolaos Kanellias, Marini Tselegkidi, Elektra Papadopoulou, Dimitrios C. Ziogas, Kimon Stamatelopoulos, Efstathios Manios, Argyrios Ntalianis, Evangelos Eleutherakis-Papaiakovou, Magdalini Migkou, Fotiou Despina, Asimina Papanikolaou, Charikleia Gakiopoulou, Erasmia Psimenou, Ioanna Tatouli, Ioannis Ntanasis-Stathopoulos, Tina Bagratuni, Alexandra Papathoma, Marilyn Spyropoulou-Vlachou, Stavroula Giannouli, Evangelos Terpos, Meletios A Dimopoulos
Journal: Blood (2018)
Medical News &amp;amp; Perspectives
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Primary Adenosquamous Carcinoma of the Liver on FDG PET/CT
Authors: Nuh Filizoglu, Kevser Oksuzoglu, Salih Ozguven
Journal: Clinical Nuclear Medicine (2021)

Abstract Primary adenosquamous carcinoma (ASC) of the liver is a rare subtype of intrahepatic cholangiocarcinoma. Hepatic ASC consists of both adenocarcinoma and squamous cell carcinoma components. Because hepatic ASC is extremely rare, only a few cases describing the imaging findings of hepatic ASC were reported before. Herein, we present FDG PET/CT findings of hepatic ASC in a 78-year-old woman who was admitted to hospital with a 4-week history of right upper quadrant pain.
Some Concerns About Imputation Methods for Missing Data
Authors: Rie Toyomoto, Satoshi Funada, Toshi A. Furukawa
Journal: JAMA Psychiatry (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Prevalence of cardiac sources of embolism in African Americans with cryptogenic cerebrovascular events Jorge R. Kizer, Frank E. Silvestry, Michael B. Erwin, Stephen E. Kimmel, Susan E. Wiegers, Scott E. Kasner, Stephanie A. Schwalm, John R. Pollard, Ted Plappert, Martin G. Keane, Martin G. St John Sutton. University of Pennsylvania Medical Center, Philadelphia, PA
Journal: Journal of the American College of Cardiology (2001)
INTERNATIONAL ABSTRACTS
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Echocardiography
Authors: Raymond Gramiak
Journal: JAMA (1974)

ULTRASONIC examination of the heart represents one of the new, developing examination modalities that has attracted considerable attention and offers promise as an important diagnostic tool in cardiac disease. Its popularity stems directly from its noninvasive, nonionizing nature, which permits easy examination, even at the bedside if necessary. The unique ability of ultrasound to differentiate solid structures of the heart from the blood<i>without the use of contrast agents</i>can be used to obtain information about cardiac structure. Records of the movement of cardiac elements also offer important information about heart function. I shall describe this examination technique and indicate conditions in which ultrasonic examination is valuable clinically. <h3>History</h3> The development of naval sonar devices in the years after World War I represents the beginning of the technology on which echocardiography is based. High-speed oscilloscopes, developed for the nondestructive testing of metals, provided the link between the long-range sonar devices
Quantitative real-time myocardial contrast echocardiography demonstrates that myocardial blood volume increases during dobutamine stress in normal humans Bettina Kuersten, Peng Li, Thippeswamy H. Murthy, Federico Paz, Elizabeth Locricchio, Mani Vannan. University of Michigan Health System, Ann Arbor, MI
Journal: Journal of the American College of Cardiology (2001)
Encapsulation of Primary Salivary Gland Acinar Cell Clusters and Intercalated Ducts (AIDUCs) within Matrix Metalloproteinase (MMP)‐Degradable Hydrogels to Maintain Tissue Structure and Function
Authors: Yuanhui Song, Azmeer Sharipol, Hitoshi Uchida, Matthew H. Ingalls, Lindsay Piraino, Jared A. Mereness, Tracey Moyston, Lisa A. DeLouise, Catherine E. Ovitt, Danielle S. W. Benoit
Journal: Advanced Healthcare Materials (2022)

Progress in the development of salivary gland regenerative strategies is limited by poor maintenance of the secretory function of salivary gland cells (SGCs) in vitro. To reduce the precipitous loss of secretory function, a modified approach to isolate intact acinar cell clusters and intercalated ducts (AIDUCs), rather than commonly used single cell suspension, is investigated. This isolation approach yields AIDUCs that maintain many of the cell-cell and cell-matrix interactions of intact glands. Encapsulation of AIDUCs in matrix metalloproteinase (MMP)-degradable PEG hydrogels promotes self-assembly into salivary gland mimetics (SGm) with acinar-like structure. Expression of Mist1, a transcription factor associated with secretory function, is detectable throughout the in vitro culture period up to 14 days. Immunohistochemistry also confirms expression of acinar cell markers (NKCC1, PIP and AQP5), duct cell markers (K7 and K5), and myoepithelial cell markers (SMA). Robust carbachol and ATP-stimulated calcium flux is observed within the SGm for up to 14 days after encapsulation, indicating that secretory function is maintained. Though some acinar-to-ductal metaplasia is observed within SGm, it is reduced compared to previous reports. In conclusion, cell-cell interactions maintained within AIDUCs together with the hydrogel microenvironment may be a promising platform for salivary gland regenerative strategies.
Storm-Related Mortality--Central Texas, October 17-31, 1998
Journal: JAMA (2000)

On October 17, 1998, a series of storms moved across the central and south regions of Texas, dropping up to 22 inches of rain in some areas and spawning several tornados. Sixty Texas counties (24%) reported flooding during October 17-19. Thirty-six counties became eligible for federal and/or state assistance as a result of damages suffered from this storm system during October 17-31. Estimated flood damage was approximately $900 million, including damage to 12,000 homes, 700 businesses, and public property. This report summarizes findings of an epidemiologic investigation of 31 deaths associated with the storm system.
High-dose rifamycins in the treatment of TB: a systematic review and meta-analysis
Authors: Omri A Arbiv, JeongMin M Kim, Marie Yan, Kamila Romanowski, Jonathon R Campbell, Anete Trajman, Leyla Asadi, Federica Fregonese, Nicholas Winters, Dick Menzies, James C Johnston
Journal: Thorax (2022)

Background There is growing interest in using high-dose rifamycin (HDR) regimens in TB treatment, but the safety and efficacy of HDR regimens remain uncertain. We performed a systematic review and meta-analysis comparing HDR to standard-dose rifamycin (SDR) regimens. Methods We searched MEDLINE, Embase, CENTRAL, Cochrane Database of Systematic Reviews and clinicaltrials.gov for prospective studies comparing daily therapy with HDRs to SDRs. Rifamycins included rifampicin, rifapentine and rifabutin. Our primary outcome was the rate of severe adverse events (SAEs), with secondary outcomes of death, all adverse events, SAE by organ and efficacy outcomes of 2-month culture conversion and relapse. This study was prospectively registered in the International Prospective Register of Systematic Reviews (CRD42020142519). Results We identified 9057 articles and included 13 studies with 6168 participants contributing 7930 person-years (PY) of follow-up (HDR: 3535 participants, 4387 PY; SDR: 2633 participants, 3543 PY). We found no significant difference in the pooled incidence rate ratio (IRR) of SAE between HDR and SDR (IRR 1.00, 95% CI 0.82 to 1.23, I 2 =41%). There was no significant difference when analysis was limited to SAE possibly, probably or likely medication-related (IRR 1.07, 95% CI 0.82 to 1.41, I 2 =0%); studies with low risk of bias (IRR 0.98, 95% CI 0.79 to 1.20, I 2 =44%); or studies using rifampicin (IRR 1.00, 95% CI 0. 0.75–1.32, I 2 =38%). No significant differences were noted in pooled outcomes of death, 2-month culture conversion and relapse. Conclusions HDRs were not associated with a significant difference in SAEs, 2-month culture conversion or death. Further studies are required to identify specific groups who may benefit from HDR.
Weight cycling. National Task Force on the Prevention and Treatment of Obesity
Authors: Richard L. Atkinson, William H. Dietz, John P. Foreyt, Norma J. Goodwin, James O. Hill, Jules Hirsch, F. Xavier Pi-Sunyer, Roland L. Weinsier, Rena Wing, Jay H. Hoofnagle, James Everhart, Van S. Hubbard, Susan Zelitch Yanovski
Journal: JAMA (1994)

To address concerns about the effects of weight cycling and to provide guidance on the risk-to-benefit ratio of attempts at weight loss, given current scientific knowledge.Original reports obtained through MEDLINE and psychological abstracts searches for 1966 through 1994 on weight cycling, "yo-yo dieting," and weight fluctuation, supplemented by a manual search of bibliographies.English-language articles that evaluated the effects of weight change or weight cycling on humans or animals.Studies were reviewed by experts in the fields of nutrition, obesity, and epidemiology to evaluate study design and the validity of the authors' conclusions based on published data.The majority of studies do not support an adverse effect of weight cycling on metabolism. Many observational studies have shown an association between variation in body weight and increased morbidity and mortality. However, most of these studies did not examine intentional vs unintentional weight loss, nor were they designed to determine the effects of weight cycling in obese, as opposed to normal-weight, individuals.The currently available evidence is not sufficiently compelling to override the potential benefits of moderate weight loss in significantly obese patients. Therefore, obese individuals should not allow concerns about hazards of weight cycling to deter them from efforts to control their body weight. Although conclusive data regarding long-term health effects of weight cycling are lacking, nonobese individuals should attempt to maintain a stable weight. Obese individuals who undertake weight loss efforts should be ready to commit to lifelong changes in their behavioral patterns, diet, and physical activity.
Roles of the BAP1 Tumor Suppressor in Cell Metabolism
Authors: Anna Han, Timothy J. Purwin, Andrew E. Aplin
Journal: Cancer Research (2021)

Abstract BRCA1-associated protein 1 (BAP1) is emerging as an intensively studied cancer-associated gene. Germline mutations in BAP1 lead to a cancer syndrome, and somatic loss is found in several cancer types. BAP1 encodes a deubiquitinase enzyme, which plays key roles in cell-cycle regulation, cell death, and differentiation. Recent studies have demonstrated that BAP1 is also involved in several aspects of cellular metabolism, including metabolic homeostasis, glucose utilization, control of ferroptosis, and stress response. A better knowledge of the metabolic roles of cancer-associated genes is important to understanding tumor initiation and progression, as well as highlighting potential therapeutic avenues. With this review, we summarize the current knowledge regarding BAP1-mediated regulation of metabolic activities that may support new strategies to treat BAP1-mutated cancers.
QUANTIFICATION OF ABSOLUTE MYOCARDIAL PERFUSION IN PATIENTS WITH CORONARY ARTERY DISEASE: COMPARISON BETWEEN CARDIAC MAGNETIC RESONANCE AND POSITRON EMISSION TOMOGRAPHY
Authors: Geraint Morton, Amedeo Chiribiri, Masaki Ishida, Shazia Hussain, Andreas Schuster, Andreas Indermuehle, Divaka Perera, Erik Hedstrom, Sally Barrington, Eike Nagel
Journal: Journal of the American College of Cardiology (2012)
Age plays role in success of aortal coarctation repair
Authors: B. J. Montgomery
Journal: JAMA (1979)

Surgical repair of coarctation of the aorta, first successfully performed more than 30 years ago, generally has been considered curative. Yet persistent hypertension and unexpected mortality in some patients have raised questions about the long-term success of this operation in adults. A 30-year (1947 to 1976) retrospective study of 114 adults who underwent such operations at three University of Toronto hospitals shows that there is a significantly higher rate of complications and mortality in patients who were older than 25 years at the time of surgery. The average age for surgery in the younger-than25-years group was 19.4 years, and the follow-up period was 10.8 years. In the older-than-25-years group, the average age at surgery was 34.97 years, with follow-up carried out 10.0 years later. Reporting in Miami to the American College of Cardiology, chief investigator John P. Rowen, MD, said that of the "over-25" patients, only 28% were normotensive at
Differential roles of BAF and PBAF subunits, Arid1b and Arid2, in MLL-AF9 leukemogenesis
Authors: Theresa Bluemn, Jesse Schmitz, Yongwei Zheng, Robert Burns, Shikan Zheng, Joshua DeJong, Luke Christiansen, Olivia Arnold, Jesus Izaguirre-Carbonell, Demin Wang, Aniruddha J. Deshpande, Nan Zhu
Journal: Leukemia (2022)
PPAR-γ integrates obesity and adipocyte clock through epigenetic regulation of <i>Bmal1</i>
Authors: Shuai Wang, Yanke Lin, Lu Gao, Zemin Yang, Jingpan Lin, Shujing Ren, Feng Li, Jing Chen, Zhigang Wang, Zhiyong Dong, Pinghua Sun, Baojian Wu
Journal: Theranostics (2022)

While growing evidence suggests that circadian clock and obesity are intertwined, the underlying mechanism is poorly understood.Here, we investigate how circadian clock is linked to obesity.Methods: Metabolomics profiling of WAT (white adipose tissue) samples was performed to identify the metabolites altered in obese model.mRNA levels were analyzed by qPCR assays.Proteins were detected by immunoblotting, immunofluorescence and ELISA.ChIP and luciferase reporter assays were used to investigate epigenetic and transcriptional regulation.Results: Obesity causes perturbance of circadian clock in WAT in mice and humans, particularly, BMAL1 is markedly reduced.Metabolomic analysis reveals reduced glutamine and methionine in obese WAT.Glutamine metabolism contributes to production of acetyl-CoA, whereas methionine metabolism generates S-adenosyl methionine (SAM).Acetyl-CoA and SAM are the substrates for histone acetylation and methylation, respectively.Reduced glutamine and methionine in obese WAT are associated with decreased H3K27ac and H3K4me3 at Bmal1 promoter.Consistently, glutamine or methionine administration in vitro and in vivo increases H3K27ac or H3K4me3, promoting Bmal1 transcription and expression.A screen of transport and metabolic genes identifies downregulation of the uptake transporter SLC1A5 as a cause of reduced glutamine or methionine in obese WAT.Moreover, we observe impaired expression of PPAR- in obese WAT.PPAR- trans-activates Slc1a5 via direct binding to a response element in promoter. Conclusion:Impaired PPAR- in obesity provokes downregulation of SLC1A5 and reductions in adipocyte uptake of glutamine and methionine (two epigenetic modulators), leading to disruption of Bmal1.Therefore, PPAR- integrates obesity and adipocyte clock, promoting a vicious cycle between circadian disruption and obesity development.