tbuckley/cabot-search huggingface dataset:
Molecular characterization of mutant <i>TP53</i> acute myeloid leukemia and high-risk myelodysplastic syndrome
Authors: Tim Grob, Adil S. A. Al Hinai,  Mathijs A. Sanders, François G. Kavelaars, Melissa Rijken, Patrycja L. Gradowska, Bart J. Biemond, Dimitri A. Breems, Johan Maertens, Marinus van Marwijk Kooy, Thomas Pabst, Okke de Weerdt, Gert J. Ossenkoppele, Arjan A. van de Loosdrecht, Gerwin A. Huls, Jan J. Cornelissen, H. Berna Beverloo, Bob Löwenberg, Mojca Jongen-Lavrencic, Peter J. M. Valk
Journal: Blood (2022)

Substantial heterogeneity within mutant TP53 acute myeloid leukemia (AML) and myelodysplastic syndrome with excess of blast (MDS-EB) precludes the exact assessment of prognostic impact for individual patients. We performed in-depth clinical and molecular analysis of mutant TP53 AML and MDS-EB to dissect the molecular characteristics in detail and determine its impact on survival. We performed next-generation sequencing on 2200 AML/MDS-EB specimens and assessed the TP53 mutant allelic status (mono- or bi-allelic), the number of TP53 mutations, mutant TP53 clone size, concurrent mutations, cytogenetics, and mutant TP53 molecular minimal residual disease and studied the associations of these characteristics with overall survival. TP53 mutations were detected in 230 (10.5%) patients with AML/MDS-EB with a median variant allele frequency of 47%. Bi-allelic mutant TP53 status was observed in 174 (76%) patients. Multiple TP53 mutations were found in 49 (21%) patients. Concurrent mutations were detected in 113 (49%) patients. No significant difference in any of the aforementioned molecular characteristics of mutant TP53 was detected between AML and MDS-EB. Patients with mutant TP53 have a poor outcome (2-year overall survival, 12.8%); however, no survival difference between AML and MDS-EB was observed. Importantly, none of the molecular characteristics were significantly associated with survival in mutant TP53 AML/MDS-EB. In most patients, TP53 mutations remained detectable in complete remission by deep sequencing (73%). Detection of residual mutant TP53 was not associated with survival. Mutant TP53 AML and MDS-EB do not differ with respect to molecular characteristics and survival. Therefore, mutant TP53 AML/MDS-EB should be considered a distinct molecular disease entity.
Autoimmmune hepatitis
Authors: Benedetta Terziroli Beretta-Piccoli, Giorgina Mieli-Vergani, Diego Vergani
Journal: Cellular and Molecular Immunology (2021)

Autoimmune hepatitis (AIH) is a T-cell mediated, inflammatory liver disease affecting all ages and characterized by female preponderance, elevated serum transaminase and immunoglobulin G levels, positive circulating autoantibodies, and presence of interface hepatitis at liver histology. AIH type 1, affecting both adults and children, is defined by positive anti-nuclear and/or anti-smooth muscle antibodies, while type 2 AIH, affecting mostly children, is defined by positive anti-liver-kidney microsomal type 1 and/or anti-liver cytosol type 1 antibody. While the autoantigens of type 2 AIH are well defined, being the cytochrome P4502D6 (CYP2D6) and the formiminotransferase cyclodeaminase (FTCD), in type 1 AIH they remain to be identified. AIH-1 predisposition is conferred by possession of the MHC class II HLA DRB1*03 at all ages, while DRB1*04 predisposes to late onset disease; AIH-2 is associated with possession of DRB1*07 and DRB1*03. The majority of patients responds well to standard immunosuppressive treatment, based on steroid and azathioprine; second- and third-line drugs should be considered in case of intolerance or insufficient response. This review offers a comprehensive overview of pathophysiological and clinical aspects of AIH.
Household air pollution: a call to action
Authors: Alison Lee, Paul R O C Adobamen, Orighomisan Agboghoroma, Fahmi Oumer Ahmed, Adesuwa Aigbokhaode, Ganiyu Adeniyi Amusa, Euripide Avokpaho, Babatunde Awokola, Joy Ibeh, Godsent Isiguzo, Jacqueline Kagima, Bankole Peter Kuti, Hervé Lawin, Norman Lufesi, Ndubuisi Mokogwu, Esther Ngadaya, Motto Malea Nganda, Ogonna Nwota Nwankwo, Perpetua Obiajunwa, Sunday Oghuvwu, Obianuju Ozoh
Journal: The Lancet Respiratory Medicine (2015)
Translating lessons learned on the role of HLA in immunological responses in LEAP to peanut OIT Trials: IMPACT and POISED
Authors: Kanika Kanchan, Gautam Shankar, Michelle Huffaker, Henry Bahnson, R Sharon Chinthrajah, Srinath Sanda, Monali Manohar, George Du Toit, Ingo Ruczinski, Gideon Lack, Kari Nadeau, Stacie Jones, Gerald Nepom, Rasika Mathias
Journal: Journal of Allergy and Clinical Immunology (2022)
Abstract 286: Factors Associated with Non-survival From In-hospital Maternal Cardiac Arrest: An Analysis of Get with the Guidelines (gwtg) Data
Authors: Carolyn M Zelop, Richard E Shaw, Dana P Edelson, Steven S Lipman, Jill M Mhyre, Farida Jeejeebhoy, Sharon Einav
Journal: Circulation (2020)

Introduction: Maternal mortality has risen in the United States during the 21 st century. Factors influencing outcome of maternal cardiac arrest (MCA) remain largely unexplored. Hypothesis: We sought to further elucidate the factors affecting maternal death from in-hospital (IH) MCA. Methods: Our query of the American Heart Association’s GWTG ® -Resuscitation voluntary registry from 2000-2017 revealed 561 index cases of in IH MCA with complete outcome data. Logistic regression was performed using hospital death as the primary outcome and included variables with a p value = 0.1 or less based upon univariate analysis. Age, race, year of arrest, pre-existing conditions, first documented pulseless rhythm, and location of arrest were used in the model. Sensitivity analyses and assessment of variable interaction were also performed to test model stability. Results: Among 561 cases of MCA, 57.2% (321/561) did not survive to hospital discharge. In-hospital death was not associated with maternal age, race and year of event. In the final model (see table), IH death was significantly associated with prearrest hypotension/hypoperfusion (p=0.009). While MCA cases with a shockable vs non-shockable first documented pulseless rhythm had similar outcomes, those with an indeterminate rhythm were less likely to die, (p=0.014). The occurrence of MCA outside of the delivery suite (referent group) or operating room was associated with a significantly higher risk of death: ICU/Recovery Room (p=0.001) and ER/other (p= 0.012). In a sensitivity analysis, removal of the indeterminate group did not alter outcomes regarding first documented pulseless rhythm or arrest location. Area under the curve for the final model was 0.715 (95% CI 0.673-0.757). Conclusions: Our study identified several novel factors associated with IH death of our MCA cohort. More research is required to further understand the pathophysiologic dynamics affecting outcomes of IHCA in this unique population.
Spindle‐Like Zinc Silicate Nanoparticles Accelerating Innervated and Vascularized Skin Burn Wound Healing
Authors: Hongjian Zhang, Wenping Ma, Hongshi Ma, Chen Qin, Jiajie Chen, Chengtie Wu
Journal: Advanced Healthcare Materials (2022)

The treatment of severe burn injuries is a crucial challenge in skin tissue engineering. Severe burns are always accompanied with large-area neurovascular networks damage, leading to the lack of excitation functions and difficulty in self-healing. Therefore, it is of great importance to develop biomaterials which can not only promote wound healing but also simultaneously reconstruct cutaneous neurovascular networks. In this study, Zn2 SiO4 (ZS) nanoparticles-incorporated bioactive nanofibrous scaffolds are designed for innervated and vascularized skin burn wound healing. ZS nanoparticles with spindle-like morphology are synthesized via a facile hydrothermal method. The incorporation of ZS nanoparticles endows the scaffolds with excellent angiogenic and neurogenic activities in vitro. Additionally, in vivo results show that the ZS nanoparticles-incorporated scaffolds have favorable re-epithelialization, innervation, and vascularization abilities through local release of bioactive Zn and Si ions from ZS nanoparticles, leading to rapid wound healing featuring with newly formed blood vessels and nerve fibers. Taken together, this study suggests that the spindle-like ZS nanoparticles are useful bioactive agents for stimulating vascularization and innervation of functional skin repair. The bioactive inorganic nanoparticles may be used for multifunctional tissue regeneration.
National HIV Testing Day — June 27, 2019
Journal: MMWR Morbidity and Mortality Weekly Report (2019)

National HIV Testing Day, observed each year on June 27, highlights the importance of testing in detecting, treating, and preventing human immunodeficiency virus (HIV) infection. Early diagnosis is critical to controlling HIV transmission in the United States (1). With the aim of reducing the number of new infections in the United States by 90% in 10 years, the Ending the HIV Epidemic initiative initially will focus on the 50 local jurisdictions where approximately half of diagnoses made in 2016 and 2017 were concentrated and in seven states with a disproportionate occurrence of HIV in rural areas (2). An analysis of 2016 and 2017 population-based survey data reported in this issue of MMWR found that overall, 38.9% of the U.S. population had ever tested for HIV infection, including 46.9% in the 50 local jurisdictions with the majority of diagnoses and 35.5% in the seven states with disproportionate occurrence of HIV in rural areas. To control HIV transmission, health care providers and public health practitioners need to develop HIV testing strategies to reach segments of the population that have never tested for HIV infection and offer at least annual testing of persons at risk for infection.
A super-stable homogeneous Lipiodol-hydrophilic chemodrug formulation for treatment of hepatocellular carcinoma
Authors: Pan He, En Ren, Biaoqi Chen, Hu Chen, Hongwei Cheng, Xing Gao, Xiaoliu Liang, Hao Liu, Jingdong Li, Bo Li, Aizheng Chen, Chengchao Chu, Xiaoyuan Chen, Jingsong Mao, Yang Zhang, Gang Liu
Journal: Theranostics (2022)

Though lipiodol formulations are major options in transcatheter arterial chemoembolization (TACE) of advanced unresectable hepatocellular carcinoma (HCC) in the clinic, their application is severely limited by insufficient physical stability between the hydrophobic lipiodol and hydrophilic drugs; thus, most chemotherapeutic drugs are quickly released into systemic circulation resulting in poor therapeutic outcomes and serious side effects.
Zenocutuzumab Shines in PDAC
Journal: Cancer Discovery (2021)

Zenocutuzumab, an investigational bispecific antibody, has shown early efficacy in an ongoing phase I/II study of patients with tumors harboring NRG1 fusions. The data so far appear particularly promising in NRG1 fusion-positive pancreatic ductal adenocarcinoma, which tends to occur in younger patients.
Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signaling Pathway Determines The Outcome Of T Cell Antigen Receptor Occupancy
Authors: D. Mueller
Journal: Annual Review of Immunology (1989)

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, ...Read More
TRIGGER FINGER.
Authors: ROBERT F. WEIR
Journal: JAMA (1907)

This affection, which is generally known by the title trigger finger, is also called variously digitus recellens or lock or snapping finger and sometimes spasm of the finger<sup>1</sup>. The original title given to it by Notta and Nélaton was "doigt à ressort" (spring finger), and in Germany it is called "schnellender" or "federnen finger" (snapping or spring finger). It is nearly always met with in flexion (Fig. 1), and particularly in flexion sufficiently great to allow the tip of the finger to rest or to press firmly on the palm of the hand. When the trigger action is present the finger can only be extended by a considerable muscular effort, or by the aid of the other hand. In overcoming the hitch by the action of the extensor muscles the finger springs back suddenly and usually with more or less pain, though when arrested or replaced by the sound
Contents
Authors: Daniel Zander, Daniel Böhringer, Marianne Fritz, Viviane Grewing, Philip Maier, Thabo Lapp, Thomas Reinhard, Katrin Wacker, Mark Christopher, Christopher Bowd, James Proudfoot, Akram Belghith, Michael Goldbaum, Jasmin Rezapour, Massimo Fazio, Christopher Girkin, Gustavo De Moraes, Jeffrey Liebmann, Robert Weinreb, Linda Zangwill, Ling Zhen, Edin Teo, Yih-Chung Tham, Marco Yu, Miao Chee, Tyler Rim, Ning Cheung, Mukharram Bikbov, Ya Wang, Yating Tang, Yi Lu, Ian Wong, Daniel Shu, Wei Ting, Gavin Siew, Wei Tan, Jost Jonas, Charumathi Sabanayagam, Tien Wong, Ching-Yu Cheng, Clement Chan, Calvin Mein, Adam Glassman, Wesley Beaulieu, Claire Calhoun, Glenn Jaffe, Lee Jampol, Mathew Maccumber, Maureen Maguire, Raj Maturi, Hani Salehi-Had, Soraya Rofagha, Jennifer Sun, Daniel Martin, Retina Network, Anita De Breuk, Ilhan Acar, Eveline Kersten, Mascha Schijvenaars, Johanna Colijn, Lonneke Haer-Wigman, Bjorn Bakker, Sarah De Jong, Magda Meester-Smoor, Timo Verzijden, Tom Missotten, Jordi Monés, Marc Biarnés, Daniel Pauleikhoff, Hans Hense, Rufino Silva, Sandrina Nunes, Joana Melo, Sascha Fauser, Carel Hoyng, Marius Ueffing, Marieke Coenen, Caroline Klaver, Anneke Den Hollander, Koushik Tripathy, Rohan Chawla, Reply Daich Varela, Brian Brooks
Journal: Ophthalmology (2021)
Intracoronary adenosine administered during rotational atherectomy of complex lesions in native coronary arteries reduce the incidence of ‘no reflow’ phenomenon
Authors: G.P. Hanna, P. Yhip, K. Fujise, G.W. Schroth, O.R. Rosales, H.V. Anderson, R.W. Smelling
Journal: Journal of the American College of Cardiology (1998)
Galactose-Deficient IgA1 B cells in the Circulation of IgA Nephropathy Patients Carry Preferentially Lambda Light Chains and Mucosal Homing Receptors
Authors: Katerina Zachova, Jana Jemelkova, Petr Kosztyu, Yukako Ohyama, Kazuo Takahashi, Josef Zadrazil, Jiri Orsag, Karel Matousovic, Dana Galuszkova, Nadezda Petejova, Jiri Mestecky, Milan Raska
Journal: Journal of the American Society of Nephrology (2022)

IgA nephropathy (IgAN) primary glomerulonephritis is characterized by the deposition of circulating immune complexes composed of polymeric IgA1 molecules with altered O-glycans (Gd-IgA1) and anti-glycan antibodies in the kidney mesangium. The mesangial IgA deposits and serum IgA1 contain predominantly λ light (L) chains, but the nature and origin of such IgA remains enigmatic.We analyzed λ L chain expression in peripheral blood B cells of 30 IgAN patients, 30 healthy controls (HCs), and 18 membranous nephropathy patients selected as disease controls (non-IgAN).In comparison to HCs and non-IgAN patients, peripheral blood surface/membrane bound (mb)-Gd-IgA1+ cells from IgAN patients express predominantly λ L chains. In contrast, total mb-IgA+, mb-IgG+, and mb-IgM+ cells were preferentially positive for kappa (κ) L chains, in all analyzed groups. Although minor in comparison to κ L chains, λ L chain subsets of mb-IgG+, mb-IgM+, and mb-IgA+ cells were significantly enriched in IgAN patients in comparison to non-IgAN patients and/or HCs. In contrast to HCs, the peripheral blood of IgAN patients was enriched with λ+ mb-Gd-IgA1+, CCR10+, and CCR9+ cells, which preferentially home to the upper respiratory and digestive tracts. Furthermore, we observed that mb-Gd-IgA1+ cell populations comprise more CD138+ cells and plasmablasts (CD38+) in comparison to total mb-IgA+ cells.Peripheral blood of IgAN patients is enriched with migratory λ+ mb-Gd-IgA1+ B cells, with the potential to home to mucosal sites where Gd-IgA1 could be produced during local respiratory or digestive tract infections.
a Phase I Study of BKM120 (Buparlisib) and Rituximab in Patients with Relapsed or Refractory (R/R) B-Cell Non-Hodgkin's Lymphoma (NHL)
Authors: Kami J. Maddocks, Jonathon B. Cohen, Ying Huang, Beth A Christian, Don M Benson, Jeffrey Jones, Christopher Flowers, Leonard T. Heffner, Cynthia Jenkins, Jennfer Sexton, Alison Neal, Melissa Kives, Kristie A. Blum
Journal: Blood (2016)
Children With Shellfish Allergy Have A Higher Risk Of Cockroach Sensitization
Authors: Aame Andy Nweye, Rishi Jaswaney, Susan Fox, Mary Tobin, Neil Thivalapill, Khalid Ibrahim, Annika Chura, Izeris Ortiz Rodriguez, Pamela Newmark, Jialing Jiang, Haley Hultquist, Sai Nimmagadda, Andrea Pappalardo, Christopher Warren, Jacqueline Pongracic, Hemant Sharma, Amal Assa'ad, Lucy Bilaver, Ruchi Gupta, Mahboobeh Mahdavinia
Journal: Journal of Allergy and Clinical Immunology (2022)
Source of Firearms Used by Students in School-Associated Violent Deaths—United States, 1992-1999
Journal: JAMA (2003)

During July 1, 1992-June 30, 1999, a total of 323 school-associated violent death events occurred in the United States, resulting in 358 deaths. To guide prevention efforts, CDC examined school-associated firearm violent death events committed by students in elementary and secondary schools in the United States and determined the sources of the firearms used in these events. The findings indicate that, among the incidents for which data are available, the majority of the firearms used in these events were obtained from perpetrators' homes or from friends or relatives. The safe storage of firearms is critically important and should be continued. In addition, other strategies that might prevent firearm-related injuries and deaths among students, such as safety and design changes for firearms, should be evaluated.
The years of living dangerously
Authors: B. B. Dan
Journal: JAMA (1987)

Since the first report of<i>Pneumocystis carinii</i>pneumonia in five homosexual men in Los Angeles in 1981,<sup>1</sup>more than 10 000 citations about aspects of the acquired immunodeficiency syndrome (AIDS) have appeared in the medical and scientific literature. The appearance of several compilations of previously published journal articles, including that of the more than 600 citations appearing inThe Journal,<sup>2</sup>attest to the level of scientific preoccupation with this new entity. The intense medical interest during the last few years and the frightening potential of an unprecedented pandemic have led to attempts to outline methods for halting the spread of AIDS. In this issue ofThe Journal, Francis and Chin<sup>3</sup>describe a strategy to prevent AIDS in the United States. Not surprisingly, one major thrust of the battle plan for the war on AIDS revolves around preventing the transmission of the causative agent, the human immunodeficiency virus,
Effect of Angiotensin II on the Intact Forearm Veins of Man
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Microenvironment Is a Key Determinant of Immune Checkpoint Inhibitor Response
Authors: Shih-Feng Cho, Kenneth C. Anderson, Yu-Tzu Tai
Journal: Clinical Cancer Research (2022)

Summary Utilizing advanced RNA-sequencing techniques and rigorous bioinformatics analysis, this study identified gene signatures predicting responsiveness to pembrolizumab monotherapy. T-cell–inflamed gene expression profile was predictive for better treatment response, while angiogenesis, monocytic myeloid–derived suppressor cell, and stroma/epithelial–mesenchymal transition/TGFβ gene signatures were associated with lower treatment response. See related article by Cristescu et al., p. 1680
Serum levels of Galectin-10 increase in active eosinophilic granulomatosis with polyangiitis
Authors: Yosuke Kamide, Shigeharu Ueki, Mineyo Fukuchi, Norihiro Fujita, Akio Mori, Masami Taniguchi, Kiyoshi Sekiya
Journal: Journal of Allergy and Clinical Immunology (2022)
Do Oral Challenges Alter Prescribing Practices? A MarketScan Study Evaluating Use of First-Line Antibiotics for Sinus Infections
Authors: Kevin Diehl, Matthew Norris, Timothy Craig, Jennifer Kraschnewski, Morgan Kim, Maria Paula Henao
Journal: Journal of Allergy and Clinical Immunology (2022)

Patients with drug allergy labels have increased length of hospitalizations, healthcare costs, multidrug-resistant organisms, and surgical site infections. Oral challenges can be used to remove drug allergy labels in patients that are not truly allergic or that have outgrown their allergy. No prior studies to our knowledge have evaluated the effects of challenges on prescribing practices. We aimed to determine the effect of oral challenges on use of beta-lactam antibiotics, which are the first-line antibiotics for treatment of acute bacterial sinusitis.
Interstitial lung abnormalities are associated with decreased mean telomere length
Authors: Rachel K. Putman, Gisli Thor Axelsson, Samuel Y. Ash, Jason L. Sanders, Aravind A. Menon, Tetsuro Araki, Mizuki Nishino, Masahiro Yanagawa, Elías F. Gudmundsson, Dandi Qiao, Raúl San José Estépar, Josée Dupuis, George T. O'Connor, Ivan O. Rosas, George R. Washko, Souheil El-Chemaly, Benjamin A. Raby, Vilmundur Gudnason, Dawn L. DeMeo, Edwin K. Silverman, Hiroto Hatabu, Immaculata De Vivo, Michael H. Cho, Gunnar Gudmundsson, Gary M. Hunninghake
Journal: European Respiratory Journal (2022)

Background Interstitial lung abnormalities (ILA) share many features with idiopathic pulmonary fibrosis; however, it is not known if ILA are associated with decreased mean telomere length (MTL). Methods Telomere length was measured with quantitative PCR in the Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene) and Age Gene/Environment Susceptibility Reykjavik (AGES-Reykjavik) cohorts and Southern blot analysis was used in the Framingham Heart Study (FHS). Logistic and linear regression were used to assess the association between ILA and MTL; Cox proportional hazards models were used to assess the association between MTL and mortality. Results In all three cohorts, ILA were associated with decreased MTL. In the COPDGene and AGES-Reykjavik cohorts, after adjustment there was greater than twofold increase in the odds of ILA when comparing the shortest quartile of telomere length to the longest quartile (OR 2.2, 95% CI 1.5–3.4, p=0.0001, and OR 2.6, 95% CI 1.4–4.9, p=0.003, respectively). In the FHS, those with ILA had shorter telomeres than those without ILA (−767 bp, 95% CI 76–1584 bp, p=0.03). Although decreased MTL was associated with chronic obstructive pulmonary disease (OR 1.3, 95% CI 1.1–1.6, p=0.01) in COPDGene, the effect estimate was less than that noted with ILA. There was no consistent association between MTL and risk of death when comparing the shortest quartile of telomere length in COPDGene and AGES-Reykjavik (HR 0.82, 95% CI 0.4–1.7, p=0.6, and HR 1.2, 95% CI 0.6–2.2, p=0.5, respectively). Conclusion ILA are associated with decreased MTL.