tbuckley/cabot-search huggingface dataset:
Reply to Suzuki <i>et al.</i>
Authors: Wytske W. Geense, Mark van den Boogaard
Journal: American Journal of Respiratory and Critical Care Medicine (2021)

We were impressed by the article by Geense and colleagues, which clarified the baseline characteristics of patients admitted to the ICU (1).Their work will contribute to further epidemiological studies on post-intensive care syndrome (PICS).However, we would like to point out three concerns regarding this study.First, there is insufficient information regarding ICU rehabilitation, although the authors emphasized the importance of rehabilitation for clinical practice in the discussion.Early mobilization may improve functional outcomes in patients admitted to the ICU (2).The long-term effects of early mobilization are unclear based on a previous systematic review (3).Did the prevalence of PICS differ between patients in the ICU who were provided early mobilization and those who were not?This information will help readers to acknowledge the importance of rehabilitation in the ICU.Second, there is insufficient information about the disposition of participants, which may affect patient-reported outcomes (4).We would like to suggest including the following information to assess the significance of this study: 1) were the patients transferred or discharged?And 2) where did the participants live a year later (back in their original living place, or returning to work or not)?Third, the authors did not report the number of cases imputed for missing values or conduct a complete case analysis.Imputation underestimates the SD, resulting in inappropriate confidence intervals (5).However, a complete case analysis assesses the significance of imputation by comparing each regression model.Addressing the aforementioned concerns can help readers interpret the results and further understand the importance of newly recognized physical, mental, and cognitive dysfunction in PICS.
Abstract P124: Neighborhood Density of Hispanic/Latinos and Left Ventricular Structure: ECHO-SOL and SOL-CASAS
Authors: Sonia Ponce, Matthew A Allison, Jordan A Carlson, Krista M Perreira, Matthew S Loop, Franklyn Gonzalez, Carmen Isasi, Barry E Hurwitz, Frank J Penedo, Mayank M Kansal, Martha L Daviglus, Gregory A Talavera, Carlos J Rodriguez, Linda G Gallo
Journal: Circulation (2018)

Introduction: Heart failure represents a significant public health problem because of increasing prevalence and lack of effective medical treatment. Hispanic/Latinos have a high burden of cardio-metabolic comorbidities and adverse socioeconomic conditions that place them at risk for heart failure. However, some literature indicates that among Hispanics/Latinos, residing in areas with high Hispanic/Latino ethnic density is associated with better health outcomes. There is a paucity of data on the effect of Hispanic/Latino ethnic density and risk markers for heart failure. Therefore, we evaluated the association between Hispanic/Latino ethnic concentration and several echocardiographic measures of left ventricular structure and function. Methods: Data on baseline characteristics from the Hispanic Communities Health Study/Study of Latinos (HCHS/SOL), echocardiographic measures of cardiac structure and function (ECHO-SOL), and neighborhood Hispanic/Latino ethnic density (San Diego SOL-CASAS) were analyzed. Hispanic/Latino ethnic density was calculated for each person based on an 800-m buffer around their home. Hispanic/Latino ethnic density was then calculated using data from the 2010 Census as the percent of Hispanic/Latinos divided by the total population at the Census block level and calculating an average value for all Census blocks that overlapped with the participant's address. Multivariable linear regression analysis adjusting for personal demographics and cardiovascular risk factors was conducted. Results: A total of 350 participants with data from all three databases were included in the analysis. The mean age was 55±7 years, 69% were female, and 26%, 38%, and 43% had diabetes, hypertension, and dyslipidemia, respectively. Thirty-six percent had less than high school education, and 58% were low income. In models adjusting for age, sex, education level, income, acculturation, and cardiovascular risk factors, a 1-percent higher Hispanic/Latino ethnic density was associated with lower left ventricular mass (0.47, p-value = 0.02). Other echocardiographic measures of cardiac structure and function were not significantly related to Hispanic/Latino ethnic density. Conclusion: Higher Hispanic/Latino ethnic density was associated with lower LVM independent of personal SES and common cardiovascular risk factors. These findings suggest that Hispanic/Latinos residing in areas with higher Hispanic/Latino ethnic density might have a lower risk of future HF. However, further research to understand the specific factors that mediate the observed associations are necessary.
27568 Maintenance of repigmentation after discontinuation of ruxolitinib cream in patients with vitiligo
Authors: David Rosmarin, Amit G. Pandya, Pearl Grimes, Mark Lebwohl, Alice B. Gottlieb, Iltefat Hamzavi, Kathleen Butler, Fiona Kuo, Shaoceng Wei, Beth Rumberger, John E. Harris
Journal: Journal of the American Academy of Dermatology (2021)
Protein Phosphatase 2A Activation Via ApoER2 in Trophoblasts Drives Preeclampsia in a Mouse Model of the Antiphospholipid Syndrome
Authors: Haiyan Chu, Anastasia Sacharidou, An Nguyen, Chun Li, Ken L. Chambliss, Jane E. Salmon, Yu-Min Shen, Julie Lo, Gustavo W. Leone, Joachim Herz, David Y. Hui, Denise K. Marciano, Vikki M. Abrahams, Bryony V. Natale, Alina P. Montalbano, Xue Xiao, Lin Xu, David R. Natale, Philip W. Shaul, Chieko Mineo
Journal: Circulation Research (2021)

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25529 Secukinumab demonstrates a consistent safety profile in patients with psoriasis, psoriatic arthritis and ankylosing spondylitis over long term: Updated pooled safety analyses
Authors: Alice Gottlieb, Atul Deodhar, Iain B. McInnes, Xenofon Baraliakos, Kristian Reich, Stefan Schreiber, Weibin Bao, Hanno B. Richards, Luminita Pricop, Philip J. Mease, Mark Lebwohl
Journal: Journal of the American Academy of Dermatology (2021)
Abstract 12712: Arrhythmia-Free Survival in Early-Persistent Atrial Fibrillation Patients Undergoing Radiofrequency Catheter Ablation
Authors: Domenico G Della Rocca, Alessio Gasperetti, Chintan Trivedi, Sanghamitra Mohanty, Veronica N Natale, Ahmin Al-Ahmad, Mustafa Abdul-Moheeth, Fahim A Choudhury, Carola Gianni, John D Burkhardt, G. Joseph Gallinghouse, Patrick Hranitzky, Javier Sanchez, Rodney Horton, Luigi Di Biase, Andrea Natale
Journal: Circulation (2018)

Introduction: Despite advances in success rate of paroxysmal atrial fibrillation (PAF) ablation, outcomes of radiofrequency catheter ablation (RFCA) in patients with persistent AF are highly variab...
Clinical features and outcomes of 1845 patients with follicular lymphoma: a real-world multicenter experience in China
Authors: Jie Zha, Liyuan Fan, Shuhua Yi, Haifeng Yu, Zhong Zheng, Wei Xu, Manman Deng, Zhijuan Lin, Zhifeng Li, Lingyan Ping, Xiaohua He, Feili Chen, Ying Xie, Biyun Chen, Huilai Zhang, Li Wang, Kaiyang Ding, Wenyu Li, Haiyan Yang, Weili Zhao, Lugui Qiu, Zhiming Li, Yuqin Song, Bing Xu
Journal: Journal of Hematology & Oncology (2021)

Abstract Clinical features and outcomes of FL patients in Chinese population are limited, thus promoting us to perform this analysis on a large cohort of 1845 patients with FL enrolled from nine medical centers nationwide in China. In this cohort, the median age of patients at diagnosis was 53 years, which was comparable to that reported previously for Chinese FL patients (49–51 years) but younger than that for Western FL patients (60–65 years). In contrast with Western patients, Chinese FL patients more likely involved extranodal sites but less frequently infiltrated bone marrow. Other clinical characteristics were comparable between two populations. In this study, 91% of patients were managed with chemotherapy, yielding 72% and 46% of overall-response rate and complete remission. After median 55-month follow-up, 5-year progressive-free and overall survival were 61% and 89%, respectively. Both were analogous to those reported in prior Chinese and Western studies. Consistent with published data, addition of rituximab into both induction ( R i ) and maintenance ( R m ) treatment led to the most favorable outcomes. Interestingly, R i only had better outcomes than R m only. Notably, 7% of patients experienced histologic transformation (HT) and correlated with poor survival. Of the transformed FL cases, 3% and 4% of HT events occurred prior to or post-treatment, respectively. Importantly, the latter displayed worse outcomes than the former. Altogether, this study provides real-world information of the largest cohort of FL patients so far in China, which might lay a foundation for clinical investigation of Chinese FL in future.
Preoperative Myocardial Strain Distribution and The Difference of Post-operative Response of Left Ventricular Function between in Aortic Regurgitation and Mitral Regurgitation
Authors: Iida Noriko, Seo Yoshihiro, Ishizu Tomoko, Yamamoto Masayoshi, Atsumi Akiko, Kawamura Ryo, Enomoto Mami, Yanaka Satomi, Nakajima Hideki, Sakamaki Fumiko, Aonuma Kazutaka
Journal: Circulation (2012)
Postoperative hiatal herniation after open vs. minimally invasive esophagectomy; a systematic review and meta-analysis
Authors: Himam Murad, Biying Huang, Nelson Ndegwa, Ioannis Rouvelas, Fredrik Klevebro
Journal: International Journal of Surgery (2021)

Post-esophagectomy hiatal hernia (PEHH) is a known, but relatively uncommon, complication after esophagectomies. The incidence of PEHH seems to be increasing since the introduction of minimally invasive esophagectomy. This systematic review and meta-analysis aimed to determine the pooled incidence of PEHH after esophagectomy, and to evaluate if minimally invasive technique is associated with increased risk for PEHH compared to open esophagectomy.A systematic search of PubMed, Medline via Ovid and Web of Science was performed. Retrospective and prospective studies in English language describing the incidence or risk factors for PEHH were included. Weighted incidence of PEHH after all types of esophagectomy, and after open or minimally invasive technique was calculated.A total of 7943 esophagectomy patients were included in the analysis. In total, 310 patients (3.9%) were diagnosed with PEHH. The estimated weighted incidence rate for PEHH after open esophagectomy was 0.024 (95% confidence interval: 0.012-0.045) compared to 0.065 (95% confidence interval: 0.040-0.106) after minimally invasive esophagectomy. Odds ratio for PEHH after minimally invasive esophagectomy compared to open esophagectomy was 2.76 (95% confidence interval: 1.49-5.11).The risk for post-esophagectomy hiatal hernia was significantly higher after minimally invasive esophagectomy compared to open technique. Heterogeneity and retrospective designs of the included studies were important limitations of the analysis. Future studies should investigate preventive measures to reduce PEHH after minimally invasive esophagectomy.
Stromal cell–derived DEL-1 inhibits Tfh cell activation and inflammatory arthritis
Authors: Hui Wang, Xiaofei Li, Tetsuhiro Kajikawa, Jieun Shin, Jong-Hyung Lim, Ioannis Kourtzelis, Kosuke Nagai, Jonathan M. Korostoff, Sylvia Grossklaus, Ronald Naumann, Triantafyllos Chavakis, George Hajishengallis
Journal: Journal of Clinical Investigation (2021)

The secreted protein developmental endothelial locus 1 (DEL-1) regulates inflammatory cell recruitment and protects against inflammatory pathologies in animal models. Here, we investigated DEL-1 in inflammatory arthritis using collagen-induced arthritis (CIA) and collagen Ab-induced arthritis (CAIA) models. In both models, mice with endothelium-specific overexpression of DEL-1 were protected from arthritis relative to WT controls, whereas arthritis was exacerbated in DEL-1-deficient mice. Compared with WT controls, mice with collagen VI promoter-driven overexpression of DEL-1 in mesenchymal cells were protected against CIA but not CAIA, suggesting a role for DEL-1 in the induction of the arthritogenic Ab response. Indeed, DEL-1 was expressed in perivascular stromal cells of the lymph nodes and inhibited Tfh and germinal center B cell responses. Mechanistically, DEL-1 inhibited DC-dependent induction of Tfh cells by targeting the LFA-1 integrin on T cells. Overall, DEL-1 restrained arthritis through a dual mechanism, one acting locally in the joints and associated with the anti-recruitment function of endothelial cell-derived DEL-1; the other mechanism acting systemically in the lymph nodes and associated with the ability of stromal cell-derived DEL-1 to restrain Tfh responses. DEL-1 may therefore be a promising therapeutic for the treatment of inflammatory arthritis.
Adjustable Sutures in the Treatment of Strabismus
Authors: Gena Heidary, Vinay K. Aakalu, Gil Binenbaum, Melinda Y. Chang, David G. Morrison, Deborah K. VanderVeen, Scott R. Lambert, Rupal H. Trivedi, Jennifer A. Galvin, Stacy L. Pineles
Journal: Ophthalmology (2021)
Opioid Use and Its Relationship to Cardiovascular Disease and Brain Health: A Presidential Advisory From the American Heart Association
Authors: Sheryl L. Chow, Comilla Sasson, Ivor J. Benjamin, Robert M. Califf, Wilson M. Compton, Elizabeth M. Oliva, Chester Robson, Eduardo J. Sanchez
Journal: Circulation (2021)

The misuse of opioids continues to be epidemic, resulting in dependency and a recent upsurge in drug overdoses that have contributed to a significant decrease in life expectancy in the United States. Moreover, recent data suggest that commonly used opioids for the management of pain may produce undesirable pharmacological actions and interfere with critical medications commonly used in cardiovascular disease and stroke; however, the impact on outcomes remains controversial. The American Heart Association developed an advisory statement for health care professionals and researchers in the setting of cardiovascular and brain health to synthesize the current literature, to provide approaches for identifying patients with opioid use disorder, and to address pain management and overdose. A literature and internet search spanning from January 1, 2012, to February 15, 2021, and limited to epidemiology studies, reviews, consensus statements, and guidelines in human subjects was conducted. Suggestions and considerations listed in this document are based primarily on published evidence from this review whenever possible, as well as expert opinion. Several federal and institutional consensus documents and clinical resources are currently available to both patients and clinicians; however, none have specifically addressed cardiovascular disease and brain health. Although strategic tools and therapeutic approaches for recognition of opioid use disorder and safe opioid use are available for health care professionals who manage patients with cardiovascular disease and stroke, high-quality evidence does not currently exist. Therefore, there is an urgent need for more research to identify the most effective approaches to improve care for these patients.
Something to Crow About!
Authors: Margaret Tempero
Journal: Journal of the National Comprehensive Cancer Network (2021)

Something to Crow About!E very summer, I start becoming a bit uneasy.When I got the privilege of serv- ing as editor-in chief of JNCCN, I set some goals to measure my success.The metrics were pretty simple, and so was the plan to achieve at least one of them: by better focusing journal content, the number of submissions should rise.With more submissions, we could curate for better content.And publishing better content would raise the impact factor of the journal accordingly.The impact factor report comes out in June or July, and for the weeks in advance of it, I start to worry.It's like waiting for your report card.Did I pass or fail?Honestly, I take this seriously!I'm proud of the journal and if I am not improving it, I should step aside.If you are not familiar with the impact factor, let me fill you in.It was devised by Eugene Garfield, the founder of the Institute for Scientific Information, and the impact factor has been calculated annually for journals since 1975. 1 It is based on the volume of citations that articles in the journal generate, and many see it as roughly akin to the quality of the journal.
Confronting the Delta Variant of SARS-CoV-2, Summer 2021
Authors: Carlos del Rio, Preeti N. Malani, Saad B. Omer
Journal: JAMA (2021)

This Viewpoint discusses the Delta variant of SARS-CoV-2, including its epidemiology, transmissibility, how uneven vaccination coverage in the US encouraged its spread, and the most effective public health responses to curb it.
Accuracy of Cardiac Magnetic Resonance Imaging in Diagnosing Pediatric Cardiac Masses
Authors: Rebecca S. Beroukhim, Sunil Ghelani, Ravi Ashwath, Sowmya Balasubramanian, David M. Biko, Sujatha Buddhe, M. Jay Campbell, Russell Cross, Pierluigi Festa, Lindsay Griffin, Heynric Grotenhuis, Keren Hasbani, Sassan Hashemi, Sanjeet Hegde, Tarique Hussain, Supriya Jain, Maria Kiaffas, Shelby Kutty, Christopher Z. Lam, Gabriela Liberato, Anthony Merlocco, Nilanjana Misra, Katie L. Mowers, Juan Carlos Muniz, Arni Nutting, David A. Parra, Jyoti K. Patel, Antonio R. Perez-Atayde, Deepa Prasad, Carlos F. Rosental, Amee Shah, Margaret M. Samyn, Lynn A. Sleeper, Timothy Slesnick, Emanuela Valsangiacomo, Tal Geva
Journal: JACC. Cardiovascular imaging (2021)
Lessons on COVID-19 from Indigenous and remote communities of the Arctic
Authors: Andrey N. Petrov, Mark Welford, Nikolay Golosov, John DeGroote, Michele Devlin, Tatiana Degai, Alexander Savelyev
Journal: Nature Medicine (2021)

Lessons on COVID-19 from Indigenous and remote communities of the ArcticTo the Editor-The Arctic provides unique insights into the COVID-19 pandemic that are of considerable importance to government policies around the world, yet experiences from the Arctic are missing from the global public-health debate 1 .Arctic remote settlements have limited access to healthcare and possess few healthcare resources with which to fight the disease 2 .In addition, Arctic populations often demonstrate higher rates of hypertension, diabetes, heart disease, tuberculosis, hepatitis and other conditions 3,4 .Despite this, in most cases, Arctic regions have fared better in the COVID-19 pandemic than have temperate areas south of the Arctic in the same countries 5 (Fig. 1a).
27082 Upadacitinib in moderate-to-severe atopic dermatitis: Combined safety analysis of phase 3 studies (Measure Up 1, Measure Up 2, and AD Up)
Authors: Emma Guttman-Yassky, Alan D. Irvine, Jonathan I. Silverberg, Kim A. Papp, Amy S. Paller, Brian Waterhouse, Allan R. Tenorio, Barry Ladizinski, Alvina D. Chu, John Liu, Kristian Reich
Journal: Journal of the American Academy of Dermatology (2021)
Magnetically assisted capsule endoscopy as a mass screening tool: is it ready for prime time?
Authors: Khek Yu Ho
Journal: Endoscopy (2021)

In their study entitled “Screening for upper gastrointestinal cancers with magnetically controlled capsule gastroscopy: a feasibility study,” Li et al. report on the use of magnetically controlled capsule gastroscopy (MCCG) to screen 6627 asymptomatic individuals in Shandong, a province in China where the incidence of upper gastrointestinal (UGI) cancer is considered to be high [1]. This was a feasibility study that reported success in detecting UGI cancers in 0.48 % of participants, among whom four had early gastric cancer and one had early esophageal cancer. The five early cancers were amenable to endoscopic resection. Ulcers were also detected in 3.76 % of these asymptomatic individuals. There were no complications associated with the examination. It is worth noting that the study population may not be extrapolated to the general population as it was a relatively young group, with a relatively low prevalence of smokers and drinkers.
Cardiovascular effects of non-insulin glucose-lowering agents: a comprehensive review of trial evidence and potential cardioprotective mechanisms
Authors: Gianluigi Savarese, Javed Butler, Lars H Lund, Deepak L Bhatt, Stefan D Anker
Journal: Cardiovascular Research (2021)

Abstract Type 2 diabetes mellitus (T2DM) is highly prevalent and associated with a two-fold increased mortality, mostly explained by cardiovascular diseases. Trial evidence on older glucose-lowering agents such as metformin and sulfonylureas is limited in terms of cardiovascular efficacy. Since 2008, after rosiglitazone was observed to increase the risk of myocardial infarction and heart failure (HF), cardiovascular outcome trials (CVOTs) have been required by regulators for licensing new glucose-lowering agents. In the following CVOTs, dipeptidyl peptidase 4 inhibitors (DPP4i) have been shown to be safe but not to improve mortality/morbidity, except for saxagliptin which increased the risk of HF. Several glucagon-like peptide-1 receptor agonists (GLP1-Ra) and sodium-glucose cotransporter-2 inhibitors (SGLT2i) have been demonstrated to reduce the risk of cardiovascular mortality and morbidity. SGLT2i have shown a class effect for the reduction in risk of HF events in patients with T2DM, leading to trials testing their efficacy/safety in HF regardless of T2DM. In the DAPA-HF and the EMPEROR-Reduced trials dapagliflozin and empagliflozin, respectively, improved cardiovascular mortality/morbidity in patients with HF with reduced ejection fraction (HFrEF), with and without T2DM. Therefore, these drugs are now key part of HFrEF pharmacotherapy. In the SOLOIST-WHF, sotagliflozin reduced cardiovascular mortality/morbidity in patients with T2DM and a recent acute episode of HF regardless of ejection fraction (EF). In the EMPEROR-Preserved, empagliflozin reduced CV mortality/morbidity in patients with heart failure with mildly reduced (HFmrEF) and preserved (HFpEF) EF regardless of comorbid T2DM. The DELIVER is currently testing dapagliflozin in patients with HFmrEF and HFrEF. A strong renal protective role of SGLT2i has also emerged in trials enrolling patients with and without T2DM.
Neutralization of the SARS-CoV-2 Delta variant after heterologous and homologous BNT162b2 or ChAdOx1 nCoV-19 vaccination
Authors: Swantje I. Hammerschmidt, Berislav Bosnjak, Günter Bernhardt, Michaela Friedrichsen, Inga Ravens, Alexandra Dopfer-Jablonka, Markus Hoffmann, Stefan Pöhlmann, Georg M. N. Behrens, Reinhold Förster
Journal: Cellular and Molecular Immunology (2021)
A new framework for developing and evaluating complex interventions: update of Medical Research Council guidance
Authors: Kathryn Skivington, Lynsay Matthews, Sharon Anne Simpson, Peter Craig, Janis Baird, Jane M Blazeby, Kathleen Anne Boyd, Neil Craig, David P French, Emma McIntosh, Mark Petticrew, Jo Rycroft-Malone, Martin White, Laurence Moore
Journal: BMJ (2021)

The UK Medical Research Council's widely used guidance for developing and evaluating complex interventions has been replaced by a new framework, commissioned jointly by the Medical Research Council and the National Institute for Health Research, which takes account of recent developments in theory and methods and the need to maximise the efficiency, use, and impact of research.