POS0165 STUDY OF VERTEBRAL AND FEMUR FRACTURE PREVALENCE AND SCANOGRAPHIC BONE ATTENUATION COEFFICIENT OF THE FIRST LUMBAR VERTEBRA IN AN ACADEMIC HOSPITAL SETTING
Authors: Z. Vaghaiwalla, P. Wasserman, G. Kaeley
Journal: Annals of the Rheumatic Diseases (2021)

Background: Patients with osteoporosis are prone to suffer fragility fractures leading to an increased risk of future fractures. Detection of osteoporosis has been led by dual energy-ray absorptiometry (DEXA) as the gold standard. However, in acute fracture incidents, DEXA imaging is typically unavailable, and treatment is often delayed. In recent years scanographic bone attenuation coefficient of the first lumbar vertebra (SBAC-L1) on incidental computed tomography (CT) scans of the lumbar spine has been utilized as an alternative assessment of bone density. In particular, SBAC-L1 ≤ 145 HU correlates with osteoporotic bone density on DEXA imaging. 2 Objectives: This study aims to assess the SBAC-L1 in HU of incidental CT scans in patients presenting with vertebra or femur fragility fractures in an academic hospital as it relates to osteoporosis. Methods: We conducted a retrospective chart review of patients aged ≥ 45 admitted to an academic hospital for active vertebral or femur fracture between 1/1/2017- 1/31/2019, excluding traumatic and pathological fractures. Measurement of SBAC-L1 in HU was obtained on incidental CT scan imaging. Sex, race, prior and post diagnoses of osteoporosis, prior and post DEXA scan orders, use of calcium, vitamin D, and steroids were abstracted. Results: There were 297 patients with vertebral or femur fractures from 1/1/2017- 1/31/2019. Of 297 patients, 85 deemed appropriate after excluding pathological, traumatic fractures, and lack of CT scan on the admission for fracture. Average SBAC-L1 for all patients was 100.4 ± standard deviation (SD) of 46.5 HU. 82% of all patients had SBAC-L1 ≤ 145 HU. Caucasian patients had a lower average SBAC-L1 [99.4 HU] than African American (AA) patients [122.1 HU]. More Caucasian [n=15] had prior diagnoses of osteoporosis than AA [n=2]. Caucasian patients were prescribed Calcium and Vitamin D more often [n=39] than AA [n=3]. DEXA scan orders were placed more often in Caucasian patients [n=4] than AA patients [n=1]. Osteoporosis medications were prescribed more often in Caucasian patients [n=8] than AA patients [n=0]. Male average SBAC-L1 was 97.4 HU compared to females at 106.3 HU. Females were prescribed calcium and vitamin D more often [n=38] than males [n=8]. DEXA scan orders were placed more frequently in females [n=5] than males [n=2]. Osteoporosis medications were prescribed more often in females [n=9] than male patients [n=0]. Table 1. Study Characteristics Total Patients [n=85] Caucasian Patients [n=67] AA Patients [n=16] Male Patients [n=31] Female Patients [n=54] SBAC- L1 Average ± SD (HU) 100.4 ± 46.5 99.4 ± 44.1 122.1 ± 49.9 97.4 ± 44.3 106.3 ± 47.2 Patients with SBAC- L1 ≤ 145 HU 70 58 10 26 44 Patients with SBAC- L1 &gt; 145 HU 15 9 6 5 10 Vertebral Fractures 57 47 8 19 38 Femur Fractures 28 20 8 12 16 Age Average 71.7 72 70.9 74 70.4 Prior diagnosis of osteoporosis 16 15 1 2 14 Post diagnosis of osteoporosis 6 2 2 2 4 Calcium 20 16 2 2 18 Vitamin D 26 23 1 6 20 Osteoporosis medication 9 8 0 0 9 Steroid use 5 4 1 2 3 DEXA prior 13 12 1 0 13 DEXA after 7 4 1 2 5 Conclusion: 70 of 85 patients with incidental fragility fractures exhibited SBAC-L1 ≤ 145 HU. This is consistent with osteoporotic bone density on DEXA imaging supporting the use of SBAC-L1 measurement to corroborate the diagnosis osteoporosis. SBAC-L1 ≤ 145 HU can be utilized to increase inpatient diagnostic confidence of osteoporosis in the setting of acute fragility fractures to allow initiation of treatment prior to awaiting outpatient DEXA imaging. The results here also highlight health disparities present among African Americans and males of all races when considering bone health. References: [1]Lewiecki, E. Michael, et al. “Healthcare policy changes in osteoporosis can improve outcomes and reduce costs in the United States.” JBMR plus 3.9 (2019): e10192. [2]Fauny, Marine, et al. “Study of vertebral fracture and Scanographic Bone Attenuation Coefficient in rheumatoid arthritis and ankylosing spondylitis vs. controls.” Scientific reports 9.1 (2019): 1-9. Disclosure of Interests: None declared