tbuckley/cabot-search huggingface dataset:
US nutritionists call for dietary guideline limits on saturated fat intake to be lifted
Authors: Maryanne Demasi
Journal: BMJ (2020)

Leading nutrition scientists have called for an urgent rethink of the 2020 US dietary guidelines, to be published at the end of this year.

In a letter to Congress, nutrition researchers and former members of the dietary guideline advisory committee (DGAC) have urged the departments of health and human services and agriculture to give “serious and immediate consideration” to lifting the cap placed on saturated fat intake.

The letter concludes that “there is no strong scientific evidence that the current population-wide upper limits on commonly consumed saturated fats in the US will prevent cardiovascular disease or reduce mortality. A continued limit on these fats is not justified.”

The conclusion runs counter to the prevailing view that consuming saturated fat raises low density lipoprotein (LDL) cholesterol and increases …
Comparison of MGUS Prevalence By Race and Family History Risk Groups Using a High Sensitivity Screening Method (MASS-FIX)
Authors: Celine M. Vachon, Josiah Murray, Cristine Allmer, Dirk Larson, Aaron D. Norman, Jason P Sinnwell, Angela Dispenzieri, Geffen Kleinstern, Robert A. Kyle, S. Vincent Rajkumar, Susan L. Slager, Shaji K. Kumar, David L. Murray
Journal: Blood (2020)
<i>Platelet-Associated Antibodies By Flow Cytometry in Adult Patients with Immune Thrombocytopenia before and after Splenectomy</i>
Authors: Kseniya A. Nikiforova, Elena K. Egorova, Yuliya O. Davydova, Nikolay M. Kapranov, Elena I. Pustovaya, Olga A. Soboleva, Irina V. Galtseva, Anait L. Melikyan, Karen I. Ntanisian, Valeriy G. Savchenko
Journal: Blood (2020)
Clinical Efficacy and Safety of Oral Decitabine/Cedazuridine in 133 Patients with Myelodysplastic Syndromes (MDS) and Chronic Myelomonocytic Leukemia (CMML)
Authors: Michael R. Savona, James K. McCloskey, Elizabeth A. Griffiths, Karen W.L. Yee, Aref Al-Kali, Amer M. Zeidan, H. Joachim Deeg, Prapti A. Patel, Mitchell Sabloff, Mary-Margaret Keating, Kim-Hien Dao, Nancy Zhu, Nashat Gabrail, Salman Fazal, Joseph Maly, Olatoyosi Odenike, Hagop M. Kantarjian, Amy E. DeZern, Casey L. O'Connell, Gail J. Roboz, Lambert Busque, Richard A. Wells, Harshad Amin, Jasleen K. Randhawa, Brian Leber, Yong Hao, Harold N. Keer, Mohammad Azab, Guillermo Garcia-Manero
Journal: Blood (2020)
Prognostic Impact of PET Findings Post-Transplant in Multiple Myeloma
Authors: Marcella Tschautscher, David Dingli, Francis K. Buadi, Martha Q. Lacy, Morie A Gertz, Angela Dispenzieri, Prashant Kapoor, Yi L. Hwa, Amie Fonder, Miriam A. Hobbs, Suzanne R. Hayman, John A. Lust, Nelson Leung, Ronald S. Go, Yi Lin, Wilson I Gonsalves, Taxiarchis Kourelis, Rahma M Warsame, Robert A. Kyle, Stephen Broski, S. Vincent Rajkumar, Shaji K. Kumar
Journal: Blood (2020)
Novel insights into ferroptosis: Implications for age-related diseases
Authors: Ren-Peng Zhou, Yong Chen, Xin Wei, Bin Yu, Zhi-Gang Xiong, Chao Lu, Wei Hu
Journal: Theranostics (2020)

Rapid increase in aging populations is an urgent problem because older adults are more likely to suffer from disabilities and age-related diseases (ARDs), burdening healthcare systems and society in general. ARDs are characterized by the progressive deterioration of tissues and organs over time, eventually leading to tissue and organ failure. To date, there are no effective interventions to prevent the progression of ARDs. Hence, there is an urgent need for new treatment strategies. Ferroptosis, an iron-dependent cell death, is linked to normal development and homeostasis. Accumulating evidence, however, has highlighted crucial roles for ferroptosis in ARDs, including neurodegenerative and cardiovascular diseases. In this review, we a) summarize initiation, regulatory mechanisms, and molecular signaling pathways involved in ferroptosis, b) discuss the direct and indirect involvement of the activation and/or inhibition of ferroptosis in the pathogenesis of some important diseases, and c) highlight therapeutic targets relevant for ARDs.
<i>Measuring the Impact of COVID-19 on Hematology-Oncology Trainees: A Quantitative and Qualitative Assessment</i>
Authors: Urshila Durani, Ana I. Velazquez Manana, Jori May, Marquita Nelson, Ze Zheng, Anurekha Gollapudi, Sara Taveras Alam, Robby Reynolds, John Colton Thompson, Ashok Kumbamu, Devika G. Das, Martina C. Murphy, Elizabeth Henry, Alfred Ian Lee, Ariela L. Marshall, Ted Wun, Lachelle Weeks
Journal: Blood (2020)
<i>KRAS</i> mutations Frequently Coexist with High-Risk <i>MLL</i> Fusions and Are Independent Adverse Prognostic Factors in <i>MLL</i>-Rearranged Acute Myeloid Leukemia
Authors: Hidemasa Matsuo, Kenichi Yoshida, Kana Nakatani, Yutarou Harata, Moe Higashitani, Yuri Ito, Yasuhiko Kamikubo, Yusuke Shiozawa, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Ai Okada, Yasuhito Nannya, June Takeda, Hiroo Ueno, Nobutaka Kiyokawa, Daisuke Tomizawa, Takashi Taga, Akio Tawa, Satoru Miyano, Manja Meggendorfer, Claudia Haferlach, Seishi Ogawa, Souichi Adachi
Journal: Blood (2020)
Assessment of Minimal Residual Disease By Next-Generation Sequencing and Fluorodeoxyglucose-Positron Emission Tomography in Patients with Relapsed/Refractory Multiple Myeloma Treated with Venetoclax in Combination with Carfilzomib and Dexamethasone
Authors: Luciano J. Costa, Nicholas Burwick, Andrzej Jakubowiak, Jonathan L. Kaufman, Fernando Cabanillas, Monique Dail, Sudeep Karve, Abdullah A. Masud, Xiaoqing Yang, Orlando F. Bueno, Sarah Mudd, Jeremy A. Ross, Faith E. Davies
Journal: Blood (2020)
Abstract MP161: A Calcineurin-hoxb13 Axis Regulates Growth Mode of Mammalian Cardiomyocytes
Authors: Ngoc Uyen Nhi Nguyen, Diana C Canseco, Feng Xiao, Yuji Nakada, Shujuan Li, Nicholas T Lam, Shalini Muralidhar, Jainy J Savla, Joseph A Hill, Zhaoning Wang, Mahmoud S Ahmed, Maimon Hubbi, Ivan Menendez-Montes, Jesung Moon, Shah R Ali, Elisa Villalobos, Waleed M Elhelaly, Suwannee Thet, Wilson Lek Wen Tan, Chukwuemeka George Anene-Nzelu, Roger Foo, Roy Jagoree, Martha S Cyert, Beverly A Rothermel, Hesham A Sadek
Journal: Circulation Research (2020)

A major factor in the progression to heart failure in humans is the inability of the adult heart to repair itself after injury. Our group recently demonstrated that the early postnatal mammalian heart is capable of regeneration following injury through proliferation of preexisting cardiomyocytes1,2. We recently also showed that Meis1, a TALE family homeodomain transcription factor, translocates to cardiomyocyte nuclei shortly after birth and mediates postnatal cell cycle arrest3. Here we report that Hoxb13 acts as a Meis1 cofactor in postnatal cardiomyocytes. Cardiomyocyte-specific deletion of Hoxb13 can both extend the postnatal window of cardiomyocyte proliferation and reactivate cardiomyocyte cell cycle in the adult heart. Moreover, adult Meis1/Hoxb13 double knockout hearts display widespread cardiomyocyte mitosis, sarcomere disassembly and an improvement in left ventricular systolic function following myocardial infarction both by echocardiography and MRI. ChIP-seq analysis demonstrates that Meis1 and Hoxb13 act cooperatively to regulate cardiomyocyte maturation and cell cycle. Finally, we show that the calcium-activated protein phosphatase calcineurin dephosphorylates Hoxb13 at serine-204 (S204), resulting in its nuclear localization and cell cycle arrest. Collectively, these results demonstrate that Meis1 and Hoxb13 act cooperatively to regulate cardiomyocyte maturation and proliferation and provide mechanistic insights into the link between hyperplastic and hypertrophic growth of cardiomyocytes.
HP0037 Establishing a one-stop direct-access joint injection clinic
Authors: PA McEleny, DA Marshall
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> All intra-articular and soft tissue injections were previously carried out at the general rheumatology clinic however due to the increasing patient referrals we developed a direct access, one-stop intra-articular and soft tissue injection clinic. <h3>Plan</h3> Training of the rheumatology nurse specialist (RNS) in intra-articular and soft tissue injection using corticosteroids took place prior to notifying general practitioners of the rapid access clinic. Local general practices were informed of the service and guidelines for referral were developed outlining the appropriate patients to refer. <h3>Action</h3> Twelve months consecutive referrals were seen at a specialist joint injection clinic. 8 patients were appointed for each clinic, allowing adequate time for assessment, education and, if required, injection. Patients were sent the Arthritis and Rheumatism Council information leaflet on intra-articular injection with their appointment and are encouraged to ask questions regarding their treatment. 269 consecutive patients were seen, assessed and treated. All were sent a questionnaire 3 months after their appointment. Referring general practitioners were also questioned to assess their impressions of the service. <h3>Results</h3> Of the 269 questionnaires sent to patients, 189 (71%) were returned. 253 (94%) patients felt that they received sufficient information prior to their appointment. Response duration (as determined by patient) was as follows; three months: 61 patients (32.2%) 172 (91%) patients stated that they would be willing to receive a further injection if required and 185 (98%) patients rated the service overall as good or very good. The survey of general practitioners, carried out six months after the clinic had commenced, returned 65 of 80 questionnaires (81%). 59 (90.8%) stated that they were aware of the clinic, 35 (53.8%) stated that they referred patients directly to the joint injection clinic, 21 (32.3%) had not required to refer patients and 9 (13.8%) continued to refer to the General Rheumatology clinic. 62 (95.4%) thought it was a valuable resource and were satisfied with the service provided. <h3>Conclusions</h3> It can be concluded from the results of the patient questionnaire that overall the joint injection clinic is a well-accepted effective method of organising joint injections, both for patients and referring doctors. This has been achieved through no need for additional funds. Importantly, it reduces pressures on the standard rheumatology clinic and provides an additional educational role, which has proved a valuable resource to health care professionals. Maximum waiting time is two weeks from referral. We are planning to introduce an electronic appointment system, whereby general practitioners can book patients appointments directly via the GPASS desktop system, with emailing of the referral letter to the clinic.
Ibrutinib Plus Rituximab (IR) Followed By Short Course R-Hypercvad/MTX in Patients (age ≤ 65 years) with Previously Untreated Mantle Cell Lymphoma - Phase-II Window-1 Clinical Trial
Authors: Michael Wang, Preetesh Jain, Yixin Yao, Yang Liu, Shuangtao Zhao, Holly Hill, Omar Moghrabi, Hun Ju Lee, Felipe Samaniego, Jason Westin, Loretta J. Nastoupil, Rashmi Kanagal-Shamanna, Chi Young Ok, Wendy Chen, Onyeka Oriabure, Yuxuan Che, Yijing Li, Lei Feng, Graciela M. Nogueras González, Guofang Xu, Nicolaus Wagner-Bartak, Selvi Thirumurthi, David Santos, Guilin Tang, Francisco Vega, C. Cameron Yin, Michelle Avellaneda, Maria Badillo, Christopher Flowers, Linghua Wang
Journal: Blood (2020)
Prognostic Value of Circulating Tumor DNA (ctDNA) in Autologous Stem Cell Graft and Post-Transplant Plasma Samples Among Patients with Diffuse Large B-Cell Lymphoma
Authors: Reid W Merryman, Robert A. Redd, Eleanor Taranto, Gulrayz Ahmed, Erin Jeter, Kristin M McHugh, Jennifer R. Brown, Jennifer Crombie, Matthew S. Davids, David C. Fisher, Arnold S. Freedman, Eric Jacobsen, Caron Jacobson, Austin I. Kim, Ann S. LaCasce, Benjamin L. Lampson, Samuel Ng, Oreofe O. Odejide, Parastoo B. Dahi, Yago Nieto, Robin M. Joyce, Yi-Bin Chen, Alex F. Herrera, Philippe Armand
Journal: Blood (2020)
Role of Neutrophil Lymphocyte Ratio [NLR] As a Biomarker of Frailty and Predictor of Survival Among Older Adults with Multiple Myeloma (MM)
Authors: Smith Giri, Susan Bal, Kelly N. Godby, Joshua Richman, Adam J Olszewski, Grant R Williams, Luciano J. Costa, Smita Bhatia
Journal: Blood (2020)
ATG and Post-Transplant Cyclophosphamide Do Not Abrogate the Inferior Outcome Risk Conferred By HLA-Α and HLA-B Mismatched Unrelated Donors
Authors: Igor Nicolas Novitzky-Basso, Remberger Mats, Carol Chen, Ivan Pasic, Zeyad Al-Shaibani, Wilson Lam, Arjun Law, Armin Gerbitz, Auro Viswabandya, Jeffrey H. Lipton, Dennis Dong Hwan Kim, Rajat Kumar, Fotios Michelis, Jonas Mattsson
Journal: Blood (2020)
AB0180 Follow up study to determinate the achievement of the peak bone mass at 18–25 years old young people
Authors: G László
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> The aim of our study was to follow up and determinate the achievement of the bone mass in young age. We wanted to study, what can influence the growth of the bone mass. <h3>Objectives</h3> We began our study 3 years ago. We made examinations among 18 years old young men and women, who begun the first class in two military academies just then. The physical education is an important part of the programme of the military academies, that?s why these groups are ideal to establish the statement, that the sport results the increasing of the bone mass in this age. We organised a control group too, in a civil university, where sporting not obligatory. The participation was voluntary. <h3>Methods</h3> Every participant filled a questionnaire about his/her earlier diseases, good and bad habits (e.g.: sport, smoking), and about his/her alimentary habits (e.g. milk and dairy products). We measured the bone density in their arms and ankle. We made anthropometrical and staying power examinations too. Finally we made laboratory tests to determinate the elements of the calcium household. The examinations were repeated two times. <h3>Results</h3> We found, that according to the osteodensitometry the bone mass have grown in all of the groups. At the soldier men’s group the increase was more significant, than at the others. The degree of bone mass growth connected with the body mass index, exactly with the growing of the body weight. According to the anthropometrical examinations the growth of the body weight came rather from the growth of the muscle mass than bone mass. Though the bone density grew, its weight did not grow significantly. <h3>Conclusion</h3> It seems that, neither the nutrition, nor the bad habits cannot influence the bone mass significantly in this young age. But the moving, sporting play important roles in the achievement of the peak bone mass.
<i>IKZF1</i> alterations predict poor prognosis in adult and pediatric T-ALL
Authors: Mathieu Simonin, Ludovic Lhermitte, Marie-Emilie Dourthe, Etienne Lengliné, Carlos Graux, Nathalie Grardel, Jean-Michel Cayuela, Isabelle Arnoux, Virginie Gandemer, Norbert Ifrah, Hervé Dombret, André Baruchel, Elizabeth Macintyre, Arnaud Petit, Nicolas Boissel, Vahid Asnafi
Journal: Blood (2020)
Isatuximab Plus Carfilzomib and Dexamethasone Versus Carfilzomib and Dexamethasone in Relapsed Multiple Myeloma Patients with Renal Impairment: Ikema Subgroup Analysis
Authors: Marcelo Capra, Thomas Martin, Philippe Moreau, Ross Baker, Ludek Pour, Chang-Ki Min, Xavier Leleu, Mohamad Mohty, Marta Reinoso Segura, Mehmet Turgut, Richard Leblanc, Marie-Laure Risse, Laure Malinge, Sandrine Schwab, Meletios A Dimopoulos
Journal: Blood (2020)
Carfilzomib Thalidomide and Dexamethasone Is Safe and Effective in the Treatment of Relapsed/Refractory Multiple Myeloma: An Open Label Phase II Australasian Leukaemia and Lymphoma Group (ALLG) MM 018/ Asian Myeloma Network (AMN) 002 Study
Authors: Hang Quach, Simon J Harrison, Je-Jung Lee, Nichloas Murphy, Jae Hoon Lee, Kim Kihyun, Jane Estell, Noemi Horvath, Richard Eek, Bradley Augustson, Philip Campbell, Rajeev Rajagopal, Soo-Mee Bang, Jeffrey SY Huang, Yoon Sung Soo, Belinda Butcher, Brian G.M. Durie, Wee Joo Chng
Journal: Blood (2020)
Trends in the Use of Telehealth During the Emergence of the COVID-19 Pandemic — United States, January–March 2020
Authors: Lisa M. Koonin, Brooke Hoots, Clarisse A. Tsang, Zanie Leroy, Kevin Farris, Brandon Jolly, Peter Antall, Bridget McCabe, Cynthia B.R. Zelis, Ian Tong, Aaron M. Harris
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

In February 2020, CDC issued guidance advising persons and health care providers in areas affected by the coronavirus disease 2019 (COVID-19) pandemic to adopt social distancing practices, specifically recommending that health care facilities and providers offer clinical services through virtual means such as telehealth.* Telehealth is the use of two-way telecommunications technologies to provide clinical health care through a variety of remote methods.† To examine changes in the frequency of use of telehealth services during the early pandemic period, CDC analyzed deidentified encounter (i.e., visit) data from four of the largest U.S. telehealth providers that offer services in all states.§ Trends in telehealth encounters during January-March 2020 (surveillance weeks 1-13) were compared with encounters occurring during the same weeks in 2019. During the first quarter of 2020, the number of telehealth visits increased by 50%, compared with the same period in 2019, with a 154% increase in visits noted in surveillance week 13 in 2020, compared with the same period in 2019. During January-March 2020, most encounters were from patients seeking care for conditions other than COVID-19. However, the proportion of COVID-19-related encounters significantly increased (from 5.5% to 16.2%; p<0.05) during the last 3 weeks of March 2020 (surveillance weeks 11-13). This marked shift in practice patterns has implications for immediate response efforts and longer-term population health. Continuing telehealth policy changes and regulatory waivers might provide increased access to acute, chronic, primary, and specialty care during and after the pandemic.
Global Initiative for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease. The 2020 GOLD Science Committee Report on COVID-19 and Chronic Obstructive Pulmonary Disease
Authors: David M. G. Halpin, Gerard J. Criner, Alberto Papi, Dave Singh, Antonio Anzueto, Fernando J. Martinez, Alvar A. Agusti, Claus F. Vogelmeier
Journal: American Journal of Respiratory and Critical Care Medicine (2020)

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has raised many questions about the management of patients with chronic obstructive pulmonary disease (COPD) and whether modifications of their therapy are required. It has raised questions about recognizing and differentiating coronavirus disease (COVID-19) from COPD given the similarity of the symptoms. The Global Initiative for Chronic Obstructive Lung Disease (GOLD) Science Committee used established methods for literature review to present an overview of the management of patients with COPD during the COVID-19 pandemic. It is unclear whether patients with COPD are at increased risk of becoming infected with SARS-CoV-2. During periods of high community prevalence of COVID-19, spirometry should only be used when it is essential for COPD diagnosis and/or to assess lung function status for interventional procedures or surgery. Patients with COPD should follow basic infection control measures, including social distancing, hand washing, and wearing a mask or face covering. Patients should remain up to date with appropriate vaccinations, particularly annual influenza vaccination. Although data are limited, inhaled corticosteroids, long-acting bronchodilators, roflumilast, or chronic macrolides should continue to be used as indicated for stable COPD management. Systemic steroids and antibiotics should be used in COPD exacerbations according to the usual indications. Differentiating symptoms of COVID-19 infection from chronic underlying symptoms or those of an acute COPD exacerbation may be challenging. If there is suspicion for COVID-19, testing for SARS-CoV-2 should be considered. Patients who developed moderate-to-severe COVID-19, including hospitalization and pneumonia, should be treated with evolving pharmacotherapeutic approaches as appropriate, including remdesivir, dexamethasone, and anticoagulation. Managing acute respiratory failure should include appropriate oxygen supplementation, prone positioning, noninvasive ventilation, and protective lung strategy in patients with COPD and severe acute respiratory distress syndrome. Patients who developed asymptomatic or mild COVID-19 should be followed with the usual COPD protocols. Patients who developed moderate or worse COVID-19 should be monitored more frequently and accurately than the usual patients with COPD, with particular attention to the need for oxygen therapy.
Safety of Emapalumab in Children with Primary Hemophagocytic Lymphohistiocytosis: Results of the Primary Analysis of the Pivotal Phase 2/3 Study
Authors: Franco Locatelli, Michael B. Jordan, Carl Allen, Simone Cesaro, Carmelo Rizzari, Anupama Rao, Barbara Degar, Tim Garrington, Julian Sevilla, Maria Caterina Putti, Franca Fagioli, Martina Ahlmann, Jose-Luis Dapena Diaz, Michael Henry, Fabrizio De Benedetti, Alexei Grom, Cristina de Min
Journal: Blood (2020)
The Dysregulation of Hepcidin-Ferroportin Axis in Childhood Acute Lymphoblastic Leukemia Survivors after Completion of Chemotherapy
Authors: Hsi-Che Liu, Ting-Chi Yeh, Jen-Yin Hou, Ting-Huan Huang, Chia-Yu Sung, Chun-Hui Lin, Syuan-You Ye, Tsai-Ying Chen
Journal: Blood (2020)
Rapid and Deep Hematologic Responses Are Associated with Improved Major Organ Deterioration Progression-Free Survival in Newly Diagnosed AL Amyloidosis: Results from Andromeda
Authors: Ashutosh D. Wechalekar, Giovanni Palladini, Giampaolo Merlini, Raymond L. Comenzo, Arnaud Jaccard, NamPhuong Tran, Huiling Pei, Sandra Y. Vasey, Brenda Tromp, Brendan M. Weiss, Jessica Vermeulen, Efstathios Kastritis
Journal: Blood (2020)
Improving Donor Selection for Haploidentical Stem Cell Transplantation with Post-Transplant Cyclophosphamide through Selective HLA-Mis/Matching
Authors: Ephraim J. Fuchs, Shannon R McCurdy, Scott R. Solomon, Tao Wang, Michelle Kuxhausen, Yvette L Kasamon, MHD Monzr Al Malki, Shahinaz Gadalla, Sophie Paczesny, Steven GE Marsh, Bronwen E. Shaw, Stephen R. Spellman, Stephanie J. Lee, Effie Petersdorf
Journal: Blood (2020)
Cigarette Smoke or Cigarette Condensate Exposure Enhances Growth of FLT3-ITD AML Models and Alters DNA Methylation and Leukemic Gene Expression
Authors: Mary Figueroa, Maninder Khosla, Yue Lu, Marcos Estecio, Seyed Javad Moghaddam, Elias Jabbour, Marina Konopleva, Courtney D. DiNardo, Joya Chandra
Journal: Blood (2020)