tbuckley/cabot-search huggingface dataset:
Assessment of response to cetuximab combined with chemotherapy in metastatic colorectal cancer according to differential expression of biomarkers (EGFR, VEGF, pAKT and PTEN) in a monocentric study
Authors: Julien Domont, Armelle Bardier, Catherine Genestie, Jean-Charles Soria, Julien Taieb, Agnes Bellanger, Laurent Hannoun, David Khayat, Frederique Capron, Jean-Philippe Spano
Journal: Cancer Research (2007)

208  Background: Recent studies have demonstrated that cetuximab is active in metastatic colorectal cancer. Thus far, these studies have been restricted to patients whose tumors expressed EGFR by immunochemistry (IHC). However, there is increasing evidence that EGFR expression is not predictive of response to cetuximab therapy, and does not properly select patients who might benefit from such therapy.Ourgoal was to obtain preliminary data regarding others molecular predictors of cetuximab therapy. Using immunohistochemical analysis, we retrospectively analyzed EGFR, HER2, VEGF, pAKT and PTEN protein expression in specimens from 48 patients with metastatic colorectal cancer (mCRC) treated with cetuximab in combination with chemotherapy for third or fourth line treatment. We obtained 60 paraffin tumoral biopsies from patients with mCRC, 26 from primitive lesions, 34 from hepatic metastasis and 14 from both lesions. These analyses were performed on tissue microarrays.  Methods: Sections of TMA blocks were stained using monoclonal or polyclonal antibodies against EGFR, HER2, pAKT and PTEN. Positive protein expression (PE) was defined as a staining of any intensity in 10% of the cells. We used the Fisher test to assess differences between the expression biomarkers according to sites of biopsy (primary or metastatic lesion) and response to cetuximab-based therapy.  Results: The PE values were 20% for EGFR, 37% for VEGF, 0% for HER2, 73% for pAKT and 58% for PTEN. In patients with dual biopsies (n=14), there was no statistically significant difference in the biomarkers expression between the primary and metastatic lesions for EGFR and pAKT, while VEGF and PTEN are frequently discordant between both lesions. There were no statistically significant difference in the biomarkers expression according to response to cetuximab based therapy: the PE values from patients with partial response (n=6) were 60% for EGFR, 50% for VEGF, 83% for pAKT and 67% for PTEN, and 50% for EGFR, 50% for VEGF, 83% for pAKT and 100% for PTEN for patients with progressive disease (n=6).  Conclusions: These preliminary results suggest thatEGFR, HER2, pAKT PE between primary and secondary lesions are similar except for PTEN and VEGF. However, these several biomarkers do not seem to correlate with response to cetuximab based therapy in metastatic colorectal cancer, with only 12 patients. An updated analysis regarding the 48 patients with clinical data will be presented at the meeting.
WHAT'S IN THE LV? A STORY OF SCAD LEADING TO ANTERIOR APICAL ANEURYSM WITH LEFT VENTRICULAR THROMBUS
Authors: Lekha Racharla, Zeel Patel, Tyler Boozel, Rahul Gupta, Sagar Vadhar, Akhil Kher, Ellina Feiner, Yasotha Rajeswaran, Daniel Makowski
Journal: Journal of the American College of Cardiology (2021)
ADULTS WITH CORONARY ARTERY DISEASE, HEART FAILURE, AND ATRIAL FIBRILLATION. A SYSTEMATIC REVIEW OF THE EFFICACY OF PSYCHOLOGICAL INTERVENTIONS ON HEALTH PARAMETERS
Authors: Nso Nso, Kaveh Rezaei Bookani, Mahmoud Nassar, Daniel Antwi-Amoabeng, Mohsen Alshamam, Anoosh Zafar Gondal, Farshid Radparvar
Journal: Journal of the American College of Cardiology (2021)
Marginal sealing around integral bilayer scaffolds for repairing osteochondral defects based on photocurable silk hydrogels
Authors: Xiaolin Wu, Mingliang Zhou, Fei Jiang, Shi Yin, Sihan Lin, Guangzheng Yang, Yuezhi Lu, Wenjie Zhang, Xinquan Jiang
Journal: Bioactive Materials (2021)

Osteochondral repair remains a major challenge in current clinical practice despite significant advances in tissue engineering. In particular, the lateral integration of neocartilage into surrounding native cartilage is a difficult and inadequately addressed problem that determines the success of tissue repair. Here, a novel design of an integral bilayer scaffold combined with a photocurable silk sealant for osteochondral repair is reported. First, we fabricated a bilayer silk scaffold with a cartilage layer resembling native cartilage in surface morphology and mechanical strength and a BMP-2-loaded porous subchondral bone layer that facilitated the osteogenic differentiation of BMSCs. Second, a TGF-β3-loaded methacrylated silk fibroin sealant (Sil-MA) exhibiting biocompatibility and good adhesive properties was developed and confirmed to promote chondrocyte migration and differentiation. Importantly, this TGF-β3-loaded Sil-MA hydrogel provided a bridge between the cartilage layer of the scaffold and the surrounding cartilage and then guided new cartilage to grow towards and replace the degraded cartilage layer from the surrounding native cartilage in the early stage of knee repair. Thus, osteochondral regeneration and superior lateral integration were achieved in vivo by using this composite. These results demonstrate that the new approach of marginal sealing around the cartilage layer of bilayer scaffolds with Sil-MA hydrogel has tremendous potential for clinical use in osteochondral regeneration.
Decoupling Crisis Response from Policing — A Step Toward Equitable Psychiatric Emergency Services
Authors: Eric Rafla-Yuan, Divya K. Chhabra, Michael O. Mensah
Journal: New England Journal of Medicine (2021)

Decoupling Crisis Response from Policing Obtaining care in a mental health crisis should be as routine and assistive as calling an ambulance for other health crises. Yet for too long, calling 911 f...
Biodegradable ZnLiCa ternary alloys for critical-sized bone defect regeneration at load-bearing sites: In vitro and in vivo studies
Authors: Zechuan Zhang, Bo Jia, Hongtao Yang, Yu Han, Qiang Wu, Kerong Dai, Yufeng Zheng
Journal: Bioactive Materials (2021)

A novel biodegradable metal system, ZnLiCa ternary alloys, were systematically investigated both in vitro and in vivo. The ultimate tensile strength (UTS) of Zn0.8Li0.1Ca alloy reached 567.60 ± 9.56 MPa, which is comparable to pure Ti, one of the most common material used in orthopedics. The elongation of Zn0.8Li0.1Ca is 27.82 ± 18.35%, which is the highest among the ZnLiCa alloys. The in vitro degradation rate of Zn0.8Li0.1Ca alloy in simulated body fluid (SBF) showed significant acceleration than that of pure Zn. CCK-8 tests and hemocompatibility tests manifested that ZnLiCa alloys exhibit good biocompatibility. Real-time PCR showed that Zn0.8Li0.1Ca alloy successfully stimulated the expressions of osteogenesis-related genes (ALP, COL-1, OCN and Runx-2), especially the OCN. An in vivo implantation was conducted in the radius of New Zealand rabbits for 24 weeks, aiming to treat the bone defects. The Micro-CT and histological evaluations proved that the regeneration of bone defect was faster within the Zn0.8Li0.1Ca alloy scaffold than the pure Ti scaffold. Zn0.8Li0.1Ca alloy showed great potential to be applied in orthopedics, especially in the load-bearing sites.
CARDIAC TAMPONADE DUE TO CONCEALED TYPE A AORTIC DISSECTION IN A PATIENT WITH NON-SMALL CELL LUNG CANCER ADJACENT TO THE AORTIC ARCH
Authors: Ryohei Ono, Sho Okada, Yuichi Saito, Hiroyuki Takaoka, Yoshio Kobayashi
Journal: Journal of the American College of Cardiology (2021)
BCOR Mutations in Myelodysplastic Syndromes (MDS): Mutation Characteristics Impact Clinical Outcomes
Authors: Nour Abuhadra, Karam Al-Issa, Sudipto Mukherjee, Cassandra M. Hirsch, Aaron T. Gerds, Babal K Jha, Vera Adema, Hassan Awada, Mohammad Fahad B Asad, Abhinav Goyal, Anjali S. Advani, Yasunobu Nagata, Bartlomiej P. Przychodzen, Hetty E. Carraway, Jaroslaw P. Maciejewski, Mikkael A. Sekeres, Aziz Nazha
Journal: Blood (2017)
The association between heart failure and incident cancer in women: an analysis of the Women's Health Initiative
Authors: Douglas J. Leedy, Kerryn W. Reding, Alexi L. Vasbinder, Garnet L. Anderson, Ana Barac, Jean Wactawski‐Wende, Aladdin H. Shadyab, Charles B. Eaton, Wayne C. Levy, LiHong Qi, Richard K. Cheng
Journal: European Journal of Heart Failure (2021)
Weighting on waiting: Willpower and attribute weighting models of decision making
Authors: Alison Harris
Journal: Behavioral and Brain Sciences (2021)

Willpower is often conceptualized as incorporating effortful and momentary suppression of immediate but ultimately inferior rewards. Yet, growing evidence instead supports a process of attribute weighting, whereby normatively optimal choices arise from separable evaluation of different attributes (e.g., time and money). Strategic allocation of attention settles conflicts between competing choice-relevant attributes, which could be expanded to include self-referential predictions ("resolve").
ACUTE PERICARDITIS AND PERICARDIAL EFFUSION IS ASSOCIATED WITH WORSE OUTCOMES IN PATIENTS UNDERGOING TRANSCATHETER AORTIC VALVE REPLACEMENT. AN INSIGHT FROM THE MOST RECENT NATIONAL INPATIENT SAMPLE 2016-2018
Authors: Kashyap Shah, Harshith Thyagaturu, Vivek Modi, Matthew Krinock, Purujit Thacker
Journal: Journal of the American College of Cardiology (2021)
EFFICACY AND SAFETY OF RIVAROXABAN IN ELDERLY PATIENTS WITH SYMPTOMATIC PAD UNDERGOING REVASCULARIZATION: INSIGHTS FROM VOYAGER PAD
Authors: Mori Krantz, William Hiatt, Sonia Anand, E. Sebastian Debus, Manesh Patel, Mark Nehler, Connie Hess, Warren H. Capell, Taylor Bracken, Scott Berkowitz, Eva Muehlhofer, Lloyd P. Haskell, Rupert Bauersachs, Marc Bonaca
Journal: Journal of the American College of Cardiology (2021)
THE ROLE OFATHERECTOMY IN CRITICAL LIMB ISCHEMIA FROM INFRAPOPLITEAL DISEASE
Authors: Irfan Helmy, Shilpkumar Arora, Zachary Zuzek, Chinmay Jani, Rahul Jaswaney, Jun Li, Mehdi Shishehbor
Journal: Journal of the American College of Cardiology (2021)
Prognostic Value of RCA Pericoronary Adipose Tissue CT-Attenuation Beyond High-Risk Plaques, Plaque Volume, and Ischemia
Authors: Pepijn A van Diemen, Michiel J Bom, Roel S Driessen, Stefan P Schumacher, Henk Everaars, Ruben W de Winter, Peter M van de Ven, Moti Freiman, Liran Goshen, Dennis Heijtel, Eran Langzam, James K Min, Jonathon A Leipsic, Pieter G Raijmakers, Albert C van Rossum, Ibrahim Danad, Paul Knaapen
Journal: JACC. Cardiovascular imaging (2021)
INCIDENCE AND DIAGNOSIS OF DEEP VEIN THROMBOSIS AND PULMONARY EMBOLISM IN COVID-19-A RETROSPECTIVE COHORT STUDY OF 1000 PATIENTS IN A COMMUNITY HOSPITAL IN CENTRAL NEW JERSEY
Authors: Kavin Raj, Sanya Chandna, Abi Watts, Anil Anandam, Kesavan Sankaramangalam, Moninuola Oluwatoba
Journal: Journal of the American College of Cardiology (2021)
Abstract 15760: Network Analysis Identifies MicroRNA 532-5p and EphrinA4 as Mediators of Vascular Smooth Muscle Calcification
Authors: Joseph Loscalzo, Amit Jhaveri, Ruisheng Wang, Jane A Leopold
Journal: Circulation (2018)

MicroRNAs (miR) play a role in vascular smooth muscle cell (VSMC) calcification by affecting expression of master regulatory proteins. We hypothesized that utilizing a systems biology approach to b...
Bariatric Surgery in Patients With Idiopathic Intracranial Hypertension—The Silver Bullet?
Authors: Deborah I. Friedman
Journal: JAMA Neurology (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
PHARMACODYNAMIC PROFILES OF DUAL ANTIPLATELET THERAPY VERSUS DUAL PATHWAY INHIBITION IN PATIENTS WITH ATHEROSCLEROTIC DISEASE MANIFESTATIONS
Authors: Francesco Franchi, Fabiana Rollini, Latonya Been, Patrick Abou Jaoude, Andrea Rivas, Xuan Zhou, Sida Jia, Naji Maaliki, Chang Hoon Lee, Andres Pineda Maldonado, Siva Suryadevara, Daniel Soffer, Martin Zenni, Lisa Jennings, Theodore Bass, Dominick Angiolillo
Journal: Journal of the American College of Cardiology (2021)
THREE-DIMENSIONAL CARDIAC REMODELLING AFTER RESTORATION TO SINUS RHYTHM IN ATRIAL FIBRILLATION: ONE YEAR FOLLOW UP
Authors: Laurie Soulat-Dufour, Sylvie Lang, Karima Addetia, Stephane Ederhy, Saroumadi Adavane-Scheuble, Marion Chauvet-Droit, Marie-Liesse Jean, Pascal Nhan, Rim Ben Said, Iris Kamami, Pauline Issaurat, Victor Mor-Avi, Franck Boccara, Roberto Lang, Ariel Cohen
Journal: Journal of the American College of Cardiology (2021)
Gene Duplication and Loss of<i>AANAT</i>in Mammals Driven by Rhythmic Adaptations
Authors: Daiqing Yin, RuRu Zhou, Mengxin Yin, Yue Chen, Shixia Xu, Guang Yang
Journal: Molecular Biology and Evolution (2021)

Arylalkylamine N-acetyltransferase (AANAT) plays a crucial role in synchronizing internal biological functions to circadian and circannual changes. Generally speaking, only one copy of AANAT gene has been found in mammals, however, three independent duplications of this gene were detected in several cetartiodactyl lineages (i.e., Suidae, Hippopotamidae, and Pecora), which originated in the middle Eocene, a geological period characterized with the increased climate seasonality. Lineage-specific expansions of AANAT and the associated functional enhancement in these lineages strongly suggest an improvement in regulating photoperiodic response to adapt to seasonal climate changes. In contrast, independent inactivating mutations or deletions of the AANAT locus were identified in the four pineal-deficient clades (cetaceans, sirenians, xenarthrans, and pangolins). Loss of AANAT function in cetaceans and sirenians could disrupt the sleep-promoting effects of pineal melatonin, which might contribute to increasing wakefulness, adapting these clades to underwater sleep. The absence of AANAT and pineal glands in xenarthrans and pangolins may be associated with their body temperature maintenance. The present work demonstrates a far more complex and intriguing evolutionary pattern and functional diversity of mammalian AANAT genes than previously thought and provides further evidence for understanding AANAT evolution as driven by rhythmic adaptations in mammals.
Management of severe covid-19: progress and promise
Authors: Cheryl K Lee, Jeffrey A Linder, Khalilah L Gates
Journal: BMJ (2021)

Management of SARS-CoV-2 infection continues to evolve.For patients requiring hospital treatment, mortality can be high (up to 20%) but has decreased over the course of the pandemic.Death rates depend on many factors, including age, gender, ethnicity, comorbidities, region, and the community prevalence of covid-19. 1 -4 Current therapeutic approaches are largely focused on one of the two phases of SARS-CoV-2 infection.The initial phase is marked by viral replication followed by a second phase associated with immune dysregulation, worsening respiratory symptoms, sepsis, organ dysfunction, and higher mortality.
Incorporating Adult Evidence Into Pediatric Research and Practice
Authors: Srinivas Murthy, Patricia Fontela, Scott Berry
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IgG Levels and Mortality in Chronic Obstructive Pulmonary Disease
Authors: Nawaf M. Alotaibi, Fernando Sergio Leitao Filho, Andre Mattman, Zsuzsanna Hollander, Virginia Chen, Raymond Ng, Janice M. Leung, Don D. Sin
Journal: American Journal of Respiratory and Critical Care Medicine (2021)

"IgG Levels and Mortality in Chronic Obstructive Pulmonary Disease." American Journal of Respiratory and Critical Care Medicine, 204(3), pp. 362–365
FIRST REPORT OF SUBCUTANEOUS HYALURONIDASE FOR RAPID RESOLUTION OF FOREARM AND HAND HEMATOMA CAUSED BY CANGRELOR IV INFILTRATION AND ACCESS SITE BLEEDING, FOLLOWING TRANSRADIAL APPROACH (TRA) PERCUTANEOUS CORONARY INTERVENTION (PCI)
Authors: Alissa Shega, Sajni Patel, Pamela Simone, Sandeep Nathan
Journal: Journal of the American College of Cardiology (2021)
SAFETY AND EFFICACY OF 1-MONTH VERSUS 3-MONTH DUAL ANTIPLATELET THERAPY IN HIGH BLEEDING RISK PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTIONS WITH AN EVEROLIMUS ELUTING STENT: INSIGHTS FROM THE XIENCE SHORT DAPT PROGRAM
Authors: Marco Valgimigli, Davide Cao, Roxana Mehran
Journal: Journal of the American College of Cardiology (2021)
Sustained fetal hemoglobin induction in vivo is achieved by <i>BCL11A</i> interference and coexpressed truncated erythropoietin receptor
Authors: Naoya Uchida, Francesca Ferrara, Claire M. Drysdale, Morgan Yapundich, Jackson Gamer, Tina Nassehi, Julia DiNicola, Yoshitaka Shibata, Matthew Wielgosz, Yoon-Sang Kim, Matthew Bauler, Robert E. Throm, Juan J. Haro-Mora, Selami Demirci, Aylin C. Bonifacino, Allen E. Krouse, N. Seth Linde, Robert E. Donahue, Byoung Ryu, John F. Tisdale
Journal: Science Translational Medicine (2021)

In xenograft mice and nonhuman primates, BCL11A interference and coexpression of a truncated erythropoietin receptor led to sustained hemoglobin F.
Anxiety-Related Adverse Event Clusters After Janssen COVID-19 Vaccination — Five U.S. Mass Vaccination Sites, April 2021
Authors: Anne M. Hause, Julianne Gee, Tara Johnson, Amelia Jazwa, Paige Marquez, Elaine Miller, John Su, Tom T. Shimabukuro, David K. Shay
Journal: MMWR Morbidity and Mortality Weekly Report (2021)

On April 7, 2021, after 5 weeks' use of the Janssen COVID-19 vaccine under the Food and Drug Administration (FDA) Emergency Use Authorization (EUA), CDC received reports of clusters of anxiety-related events after administration of Janssen COVID-19 vaccine from five mass vaccination sites, all in different states. To further investigate these cases, CDC interviewed vaccination site staff members to gather additional information about the reported events and vaccination site practices. Four of the five sites temporarily closed while an investigation took place. Overall, 64 anxiety-related events, including 17 reports of syncope (fainting), an anxiety-related event, among 8,624 Janssen COVID-19 vaccine recipients, were reported from these sites for vaccines administered during April 7-9. As a follow-up to these interviews, CDC analyzed reports of syncope shortly after receipt of Janssen COVID-19 vaccine to the Vaccine Adverse Event Reporting System (VAERS), the vaccine safety monitoring program managed by CDC and FDA. To compare the occurrence of these events with those reported after receipt of other vaccines, reports of syncopal events after influenza vaccine administered in the 2019-20 influenza season were also reviewed. Syncope after Janssen COVID-19 vaccination was reported to VAERS (8.2 episodes per 100,000 doses). By comparison, after influenza vaccination, the reporting rate of syncope was 0.05 episodes per 100,000 doses. Anxiety-related events can occur after any vaccination. It is important that vaccination providers are aware that anxiety-related adverse events might be reported more frequently after receipt of the Janssen COVID-19 vaccine than after influenza vaccination and observe all COVID-19 vaccine recipients for any adverse reactions for at least 15 minutes after vaccine administration.
Ibrutinib Has Time-dependent On- and Off-target Effects on Plasma Biomarkers and Immune Cells in Chronic Lymphocytic Leukemia
Authors: Tom A. Mulder, Lucía Peña-Pérez, Anna Berglöf, Stephan Meinke, H. Yesid Estupiñán, Kia Heimersson, Rula Zain, Robert Månsson, C. I. Edvard Smith, Marzia Palma
Journal: HemaSphere (2021)

Ibrutinib is a covalently binding inhibitor of the B-cell receptor signaling-mediator Bruton’s tyrosine kinase (BTK) with great efficacy in chronic lymphocytic leukemia (CLL). Common side effects like atrial fibrillation (AF), bleeding and infections might be caused by ibrutinib’s inhibition of other kinases in non-B cells. Five-year follow-up of plasma biomarkers by proximity extension assay and immune cell numbers by flow cytometry during ibrutinib treatment revealed that 86 of the 265 investigated plasma biomarkers significantly changed during treatment, 74 of which decreased. Among the 12 markers that increased, 6 are associated with cardiovascular diseases and therefore potentially involved in ibrutinib-induced AF. Comparison between healthy donors and X-linked agammaglobulinemia (XLA) patients, who have nonfunctional BTK and essentially lack B cells, showed indicative changes in 53 of the 265 biomarkers while none differed significantly. Hence, neither B cells nor BTK-dependent pathways in other cells seem to influence the levels of the studied plasma biomarkers in healthy donors. Regarding immune cells, the absolute number of T cells, including subsets, decreased, paralleling the decreasing tumor burden. T helper 1 (Th1) cell numbers dropped strongly, while Th2 cells remained relatively stable, causing Th2-skewing. Thus, long-term ibrutinib treatment has a profound impact on the plasma proteome and immune cells in patients with CLL.