tbuckley/cabot-search huggingface dataset:
Exosome-mediated delivery of inflammation-responsive <i>Il-10</i> mRNA for controlled atherosclerosis treatment
Authors: Te Bu, Zhelong Li, Ying Hou, Wenqi Sun, Rongxin Zhang, Lianbi Zhao, Mengying Wei, Guodong Yang, Lijun Yuan
Journal: Theranostics (2021)

Rationale: Tailored inflammation control is badly needed for the treatment of kinds of inflammatory diseases, such as atherosclerosis. IL-10 is a potent anti-inflammatory cytokine, while systemic and repeated delivery could cause detrimental side-effects due to immune repression. In this study, we have developed a nano-system to deliver inflammation-responsive Il-10 mRNA preferentially into macrophages for tailored inflammation control. Methods:Il-10 was engineered to harbor a modified HCV-IRES (hepatitis C virus internal ribosome entry site), in which the two miR-122 recognition sites were replaced by two miR-155 recognition sites. The translational responsiveness of the engineered mRNA to miR-155 was tested by Western blot or ELISA. Moreover, the engineered Il-10 mRNA was passively encapsulated into exosomes by forced expression in donor cells. Therapeutic effects on atherosclerosis and the systemic leaky expression effects in vivo of the functionalized exosomes were analyzed in ApoE-/- (Apolipoprotein E-deficient) mice. Results: The engineered IRES-Il-10 mRNA could be translationally activated in cells when miR-155 was forced expressed or in M1 polarized macrophages with endogenous miR-155 induced. In addition, the engineered IRES-Il-10 mRNA, when encapsulated into the exosomes, could be efficiently delivered into macrophages and some other cell types in the plaque in ApoE-/- mice. In the recipient cells of the plaque, the encapsulated Il-10 mRNA was functionally translated into protein, with relatively low leaky in other tissues/organs without obvious inflammation. Consistent with the robust Il-10 induction in the plaque, exosome-based delivery of the engineered Il-10 could alleviate the atherosclerosis in ApoE-/- mice. Conclusion: Our study established a potent platform for controlled inflammation control via exosome-based systemic and repeated delivery of engineered Il-10 mRNA, which could be a promising strategy for atherosclerosis treatment.
Avatrombopag: A Review in Thrombocytopenia
Authors: Anthony Markham
Journal: Drugs (2021)

Avatrombopag (Doptelet®) is an orally administered second generation thrombopoietin receptor agonist (TPO-RA) approved for the treatment of primary chronic immune thrombocytopenia (ITP) in adult patients who are refractory or have an unsatisfactory response to other treatments, as well as for the treatment of thrombocytopenia in adult patients with chronic liver disease (CLD) scheduled to undergo an invasive procedure. In phase III studies, avatrombopag was associated with a significantly greater platelet response than placebo in patients with chronic ITP, and was superior to placebo in reducing the requirement for platelet transfusion or rescue procedures for bleeding caused by surgery in patients with CLD with a platelet count < 50 × 109/L at baseline. Longer term data indicate that avatrombopag is associated with high durable response rates in ITP and may have corticosteroid-sparing effects. The drug was generally well tolerated in both indications. Avatrombopag thus represents a convenient and effective second-line treatment for patients with chronic ITP and can prevent bleeding events in patients with CLD scheduled to undergo a procedure, offering a useful alternative to other available treatments in both indications.Avatrombopag (Doptelet®) is an orally administered drug that mimics the natural compound (thrombopoietin) responsible for stimulating the production of platelets, an essential component of the clotting process that prevents excessive bleeding. Several conditions can cause reduced platelet levels (thrombocytopenia) to the point that intervention is needed to prevent excessive blood loss. Avatrombopag is approved for the treatment of primary chronic immune thrombocytopenia (ITP) and to prevent bleeding caused by surgery in patients with low platelet levels caused by chronic liver disease (CLD). Clinical trials in patients with ITP show that avatrombopag quickly increases platelet levels and that this increase is maintained in the longer term in many patients. Similarly, clinical trials in patients with low platelet levels because of CLD showed that giving avatrombopag prior to surgery reduced the need for platelet transfusions or rescue procedures for bleeding. Avatrombopag is thus a convenient and effective treatment for patients with chronic ITP and can prevent bleeding events in patients with CLD scheduled to undergo a procedure. In both indications avatrombopag offers a useful alternative to other available treatments.
<i>Salmonella</i> Typhi Vi capsule prime-boost vaccination induces convergent and functional antibody responses
Authors: Lindsay C. Dahora, Marije K. Verheul, Katherine L. Williams, Celina Jin, Lisa Stockdale, Guy Cavet, Eldar Giladi, Jennifer Hill, Dongkyoon Kim, Yvonne Leung, Benjamin G. Bobay, Leonard D. Spicer, Sheetal Sawant, Sjoerd Rijpkema, S. Moses Dennison, S. Munir Alam, Andrew J. Pollard, Georgia D. Tomaras
Journal: Science Immunology (2021)

Prime-boost vaccination with S. Typhi Vi capsule induces convergent antibodies whose function depends on specificity and avidity.
A commentary on “Endoscopic versus percutaneous biliary drainage for resectable pancreatic head cancer with hyperbilirubinemia and impact on pancreaticoduodenectomy: A randomized controlled study” [Int. J. Surg. 93 (2021 Sept 1) 106043]
Authors: Aleksandar Radulović, Sharmananthan Ganesananthan, Zoe Oakley
Journal: International Journal of Surgery (2021)
Abstract 16276: Carbon Tetrachloride Injection Induces Liver Fibrosis in Apoe-/- Mice and Increases Atherosclerosis Using a Model of Accelerated Atherosclerosis
Authors: Yu Wang, He-Ying Sun, Amir Rezvan
Journal: Circulation (2019)

Introduction: There is evidence that liver fibrosis correlates with atherosclerosis and a large body of clinical evidence supports strong association between non-alcoholic fatty liver disease and r...
Abstract 1685: Clinical and Angiographic Outcomes following Percutaneous Coronary Intervention with Sirolimus-Eluting Stents vs. Bare Metal Stents in Hemodialysis Patients
Authors: Sen Yachi, Kengo Tanabe, Hirosada Yamamoto, Shuji Otsuki, Atsuhiko Yagishita, Satoru Kishi, Shunsuke Sasaki, Masanori Taniwaki, Masataka Nakano, Hiroyoshi Nakajima, Kazuhiro Hara
Journal: Circulation (2007)

Background Percutaneous coronary intervention in hemodialysis patients has been hampered by high rate of major adverse cardiac events (MACE). It remains uncertain whether sirolimus-eluting stent (SES) improves clinical outcomes in hemodialysis patients compared to bare metal stent (BMS). Methods The present study consisted of consecutive 46 hemodialysis patients with 57 lesions treated with SES from August 2004 to April 2006. For comparison, the control group was composed of 67 hemodialysis patients with 70 lesions who were treated with BMS in three years before the introduction of SES. Clinical and angiographic follow-up were performed after 8 months. MACE included all-cause death, myocardial infarction and repeat target vessel revascularization. Results Baseline characteristics were comparable between the 2 groups except for lesion length. Clinical follow-up was available in all patients. Angiographic follow-up was obtained in 39 patients (84.8%) in the SES group and 49 patients (73.1%) in the BMS group. There was no difference in MACE between the 2 groups (SES;28.3%, BMS;40.3%, p=0.19). As shown in the table , quantitative angiographic analysis revealed a significant difference in late lumen loss (SES;0.66±0.80mm, BMS;1.07±0.75mm, p=0.01), however, the rate of binary restenosis was identical (SES;31.9%, BMS;40.4%, p=0.38). Of the angiographic restenosis lesions analyzed, focal restenosis pattern was frequently observed in the SES group than the BMS group(SES;93.3%, BMS;23.8%, p&lt;0.0001), whereas diffuse restenosis pattern was dominant in the BMS group. Conclusion Angiographic parameters favored inhibition of neointimal hyperplasia by SES. However, the inhibitory effect of sirolimus was not translated into clinical superiority over BMS in hemodialysis patients. Table. Serial QCA data
TCT-148 Outcomes After Emergent Intraprocedural Surgical Conversion During Transcatheter Aortic Valve Replacement: The Importance of On-Site Cardiac Surgery
Authors: Philipp Kiefer, Mateo Marin-Cuartas, Stefanie Naumann, Salil Deo, Thilo Noack, Alexandro Hoyer, Mohamed Abdel-Wahab, Holger Thiele, Michael Borger, David Holzhey
Journal: Journal of the American College of Cardiology (2021)
TCT-363 Does Minimalist Transcatheter Aortic Valve Replacement Miss Paravalvular Regurgitation? Incidence and Echocardiographic Distribution of “Missed” Paravalvular Regurgitation
Authors: Syed Zaid, Ahmed Abu Haniyeh, Akiva Rosenzveig, Aaqib Malik, Jayakumar Sreenivasan, Cenap Undemir, Joshua Goldberg, Steven Lansman, Gilbert Tang, Hasan Ahmad
Journal: Journal of the American College of Cardiology (2021)
Retinopathy in Malignant Hypertension
Authors: Federica Poli, Imran H Yusuf
Journal: New England Journal of Medicine (2021)

A 55-year-old man presented with a 1-week history of headache and blurred vision. His blood pressure was 250/170 mm Hg. Funduscopic examination revealed disk edema in both eyes, flame-shaped hemorrhages, hard exudates, and cotton-wool spots, findings that were consistent with malignant hypertensive retinopathy.
AKI and Collapsing Focal Segmental Glomerulosclerosis in an Immunocompetent Patient with Cytomegalovirus and COVID-19 Infection
Authors: Milton Ray, Sudhanshu Jain, Suhaib A. Andrabi, Marco Ramos
Journal: Journal of the American Society of Nephrology (2021)

Journal of the American Society of Nephrology 32(10S):p 141, October 2021. | DOI: 10.1681/ASN.20213210S1141c
Primary Membranous Nephropathy Flare After COVID-19 Vaccination
Authors: Kelly V. Liang, Elizabeth C. Kurtz, Matthew Pittappilly, Syeda B. Ahmad, Marta I. Minervini
Journal: Journal of the American Society of Nephrology (2021)

Poster: Glomerular Diseases: Clinical Features and Outcomes in Nephrotic Syndromes and Complement-Mediated Diseases
Single-cell sequencing unveils distinct immune microenvironments with CCR6-CCL20 crosstalk in human chronic pancreatitis
Authors: Bomi Lee, Hong Namkoong, Yan Yang, Huang Huang, David Heller, Gregory L Szot, Mark M Davis, Sohail Z Husain, Stephen J Pandol, Melena D Bellin, Aida Habtezion
Journal: Gut (2021)

Chronic pancreatitis (CP) is a potentially fatal disease of the exocrine pancreas, with no specific or effective approved therapies. Due to difficulty in accessing pancreas tissues, little is known about local immune responses or pathogenesis in human CP. We sought to characterise pancreatic immune responses using tissues derived from patients with different aetiologies of CP and non-CP organ donors in order to identify key signalling molecules associated with human CP.We performed single-cell level cellular indexing of transcriptomes and epitopes by sequencing and T-cell receptor (TCR) sequencing of pancreatic immune cells isolated from organ donors, hereditary and idiopathic patients with CP who underwent total pancreatectomy. We validated gene expression data by performing flow cytometry and functional assays in a second patient with CP cohort.Deep single-cell sequencing revealed distinct immune characteristics and significantly enriched CCR6+ CD4+ T cells in hereditary compared with idiopathic CP. In hereditary CP, a reduction in T-cell clonality was observed due to the increased CD4+ T (Th) cells that replaced tissue-resident CD8+ T cells. Shared TCR clonotype analysis among T-cell lineages also unveiled unique interactions between CCR6+ Th and Th1 subsets, and TCR clustering analysis showed unique common antigen binding motifs in hereditary CP. In addition, we observed a significant upregulation of the CCR6 ligand (CCL20) expression among monocytes in hereditary CP as compared with those in idiopathic CP. The functional significance of CCR6 expression in CD4+ T cells was confirmed by flow cytometry and chemotaxis assay.Single-cell sequencing with pancreatic immune cells in human CP highlights pancreas-specific immune crosstalk through the CCR6-CCL20 axis, a signalling pathway that might be leveraged as a potential future target in human hereditary CP.
Microfluidic Tandem Mechanical Sorting System for Enhanced Cancer Stem Cell Isolation and Ingredient Screening (Adv. Healthcare Mater. 20/2021)
Authors: Yuanyuan Jia, Peiliang Shen, Tao Yan, Weijia Zhou, Jia Sun, Xin Han
Journal: Advanced Healthcare Materials (2021)

Cancer Stem Cells In article number 2100985 by Jia Sun, Xin Han, and co-workers, a microfluidic tandem mechanical sorting strategy is reported to enrich cancer stem cells (CSCs) with high flexibility and low adhesive capacity. The method achieves robust isolation of CSCs in a high-throughput, label-free manner, which has promising potential for facilitating drug screening targeting CSCs and developing novel therapeutic strategies overcoming drug resistance.
TCT-444 Sex-Based Outcomes in Patients Undergoing Watchman Device Implantation
Authors: Sundeep Kumar, Ali Ghani, Hiren Patel, Ziad SayedAhmad, Ruthvik Srinivasamurthy, Sarika Kumari, Akhil Mogalapalli, Mohsin Mughal, Sayed Hussain, Philip Mar, Ammar Nasir, Kishore Harjai
Journal: Journal of the American College of Cardiology (2021)
A Case of Posterior Reversible Encephalopathy Syndrome (PRES) in an ESKD Patient with COVID-19
Authors: Victor J. Martinez, Daranee Chewaproug
Journal: Journal of the American Society of Nephrology (2021)

Journal of the American Society of Nephrology 32(10S):p 306, October 2021. | DOI: 10.1681/ASN.20213210S1306b
Pushing the frontier of endoscopic submucosal dissection in the management of colorectal lesions
Authors: André Mascarenhas, Rui Mendo, Pedro Barreiro, Cristina Chagas
Journal: Endoscopy (2021)

A 41-year-old man with familial adenomatous polyposis (FAP) recommended for prophylactic colectomy with ileorectal anastomosis was proposed for endoscopic submucosal dissection (ESD) of a superficial neoplastic colorectal lesion ([Fig. 1], [Fig. 2]). The lesion extended from the pectinate line to the distal sigmoid colon and involved 70 % of the luminal circumference. After thorough endoscopic evaluation with virtual chromoendoscopy, no evidence of invasive disease was found ([Fig. 3]).
A hybrid bacterium with tumor-associated macrophage polarization for enhanced photothermal-immunotherapy
Authors: Jingya Zhao, Huabei Huang, Jinyan Zhao, Xiang Xiong, Sibo Zheng, Xiaoqing Wei, Shaobing Zhou
Journal: Acta Pharmaceutica Sinica B (2021)

Remodeling the tumor microenvironment through reprogramming tumor-associated macrophages (TAMs) and increasing the immunogenicity of tumors via immunogenic cell death (ICD) have been emerging as promising anticancer immunotherapy strategies. However, the heterogeneous distribution of TAMs in tumor tissues and the heterogeneity of the tumor cells make the immune activation challenging. To overcome these dilemmas, a hybrid bacterium with tumor targeting and penetration, TAM polarization, and photothermal conversion capabilities is developed for improving antitumor immunotherapy in vivo. The hybrid bacteria (B.b@QDs) are prepared by loading Ag2S quantum dots (QDs) on the Bifidobacterium bifidum (B.b) through electrostatic interactions. The hybrid bacteria with hypoxia targeting ability can effectively accumulate and penetrate the tumor tissues, enabling the B.b to fully contact with the TAMs and mediate their polarization toward M1 phenotype to reverse the immunosuppressive tumor microenvironment. It also enables to overcome the intratumoral heterogeneity and obtain abundant tumor-associated antigens by coupling tumor penetration of the B.b with photothermal effect of the QDs, resulting in an enhanced immune effect. This strategy that combines B.b-triggered TAM polarization and QD-induced ICD achieved a remarkable inhibition of tumor growth in orthotopic breast cancer.
マウスでcDNAマイクロアレイ・テクニックにより検出される、主に心筋虚血による心臓遺伝子発現の変化:内因性アデノシンの役割
Authors: Asakura M, Kitakaze M, Takashima S, Sakata Y, Ogai A, Fukushima T, Yamada J, Kuzuya T, Tada M, Hori M
Journal: Circulation (1999)
TCT-288 Trends and Outcomes of Utilization of Thrombectomy During Primary Percutaneous Coronary Intervention
Authors: Michael Megaly, Ramy Sedhom, Ayman Elbadawi, Marwan Saad, Mohamed Omer, Emmanouil Brilakis, Mir Basir, Farouc Amin Jaffer, Mohammad Zaidan, Mohammad Alqarqaz, Khaldoon Alaswad
Journal: Journal of the American College of Cardiology (2021)
TCT-267 Cusp Overlap Versus Conventional Coplanar View for Deployment of Self-Expendable Evolut Prosthesis
Authors: Sunny Goel, Amit Hooda, Aakash Garg, Timothy Lee, Parasuram Krishnamoorthy, Sahil Khera, Samin Sharma, Annapoorna Kini, Gilbert Tang
Journal: Journal of the American College of Cardiology (2021)
미만성 간질환 진단에 있어서 초음파 유도하 간침생검의 정확도 - 수술 후 간조직과의 비교 -
Authors: 이영두(Young Doo Lee), 전성우(Seong Woo Jeon), 이승엽(Seung yup Lee), 박재홍(Jae Hong Park), 하승수(Seung Soo Ha), 김대현(Dae Hyun Kim), 탁원영(Won Young Tak), 권영오(Young Oh Kwon), 김성국(Sung Kuk Kim), 최용환(Yong Hwan Choi), 정준모(Joon Mo Chung), 김동자(Dong Ja Kim), 배한익(Han Ik Bae)
Journal: Clinical and Molecular Hepatology (2000)

목적: 초음파 유도하 간침생검은 합병증이 적으며 비교적 쉽게 시행할 수 있어 오늘날 간질환의 진단에 널리 이용되는 진단방법이다. 그러나 간침생검을 통하여 얻어진 간조직은 전체 간조직의 극히 일부분으로서 미만성 간질환인 간경변증과 같은 질병의 진단에 있어서는 보고자마다 상당한 진단율의 차이를 보인다. 이에 저자들은 초음파 유도하 간침생검과 수술 후 간조직의 병리조직학적 소견을 비교분석하여 간침생검의 정확도를 알아보았다. 대상과 방법: 초음파 유도하 간침생검을 통해 간세포암으로 진단받은 40예를 대상으로 배경 간조직생검을 동시에 시행하였고 이후 수술을 통해 얻어진 조직의 병리조직학적 진단의 일치율을 비교하였다. 조직학적 진단이 일치한 만성간염 6예에서 stage와 grade로 나누어 염증 및 섬유화의 정도에 대한 일치율을 비교하였고 아울러 초음파 유도하 간침생검을 통해 얻은 조직의 크기, 문맥구역수, 원인에 따른 일치율도 알아보았다. 결과: 초음파 유도하 간침생검과 수술 후 간조직의 조직학적 진단의 일치율은 75.0%였으며 원인에 따른 진단율의 차이는 없었으나 조직의 평균 크기는 조직학적 일치율을 보인 30예의 경우 1.87±0.10 cm, 불일치를 보인 10예의 경우 1.33±0.31 cm로 통계학적으로 유의한 차이를 보였으며(p<0.05), 문맥구역수에 따른 일치율은 문맥구역수가 4개 이상인 경우 79.2%, 5개 이상인 경우 100%로 4개 미만인 경우(0%)에 비해 통계학적으로 유의한 진단율의 차이를 보였다(p<0.05). 초음파 유도하 간침생검과 수술 후 간조직 소견이 일치하지 않은 경우는 10예로서 간침생검에서 간경변 8예를 만성간염으로, 그리고 간경변 1예와 만성간염 1예를 정상조직으로 판독하였는바 이는 조직의 파편화 및 부적절한 조직채취의 결과였다. 초음파 유도하 간침생검과 수술후 간조직의 진단결과가 일치했던 만성간염 6예의 경우 염증 및 섬유화 정도의 비교에서 grade는 4예(67%)에서 일치하였으나 stage는 3예(50%)에서 일치하였다. 수술 후 간조직 소견과 비교하여 간침생검소견의 조직학적 진단별 정확도는 간경변 20예 중 20예(100%), 만성간염 14예 중 6예(42.8%), 정상조직 6예 중 4예(66.7%)였다. 결론: 초음파 유도하 간침생검은 전체 간조직소견을 대변하는 비교적 정확한 검사방법으로 생각되나 간경변증이 있는 경우에는 실제 조직소견보다 경하게 나타날 수 있으므로 정확한 판독을 위해서는 적어도 4개이상의 문맥구역이 채취되어야 할 것으로 생각한다. 아울러 조직의 파편을 최소화 하여 진단의 위음성률을 줄이고 조직학적 진단과 임상적 진단이 일치하지 않는 경우, 조직의 파편이 심하거나 문맥구역이 4개 미만인 경우에는 반복적 생검 혹은 복강경하 생검 등 보다 적극적인 진단이 필요할 것으로 생각한다.
Eradication of Potential In-Transit Metastasis in Breast-Conserving Surgery—Reply
Authors: Jana de Boniface, Robert Szulkin, Anna L. V. Johansson
Journal: JAMA Surgery (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Potent Antiviral and Antimicrobial Polymers as Safe and Effective Disinfectants for the Prevention of Infections
Authors: Jiayu Leong, Danrong Shi, Jeremy Pang Kern Tan, Chuan Yang, Shengcai Yang, Yanming Wang, Yeen Shian Ngow, Jessica Kng, Nithiyaa Balakrishnan, Shu Qin Peng, Chun Siang Yeow, Balamurugan Periaswamy, Shrinivas Venkataraman, Andrea Lay‐Hoon Kwa, Xiaoli Liu, Hangping Yao, Yi Yan Yang
Journal: Advanced Healthcare Materials (2021)

Disinfection using effective antimicrobials is essential in preventing the spread of infectious diseases. This COVID-19 pandemic has brought the need for effective disinfectants to greater attention due to the fast transmission of SARS-CoV-2. Current active ingredients in disinfectants are small molecules that microorganisms can develop resistance against after repeated long-term use and may penetrate the skin, causing harmful side-effects. To this end, a series of membrane-disrupting polyionenes that contain quaternary ammoniums and varying hydrophobic components is synthesized. They are effective against bacteria and fungi. They are also fast acting against clinically isolated drug resistant strains of bacteria. Formulating them with thickeners and nonionic surfactants do not affect their killing efficiency. These polyionenes are also effective in preventing infections caused by nonenveloped and enveloped viruses. Their effectiveness against mouse coronavirus (i.e., mouse hepatitis virus-MHV) depends on their hydrophobicity. The polyionenes with optimal compositions inactivates MHV completely in 30 s. More importantly, the polyionenes are effective in inhibiting SARS-CoV-2 by >99.999% within 30 s. While they are effective against the microorganisms, they do not cause damage to the skin and have a high oral lethal dose. Overall, these polyionenes are promising active ingredients for disinfection and prevention of viral and microbial infections.
TCT-445 Feasibility and Utility of 3D Intracardiac Echocardiography to Guide Mitral and Tricuspid Transcatheter Interventions: Preliminary Experience
Authors: Pradeep Yadav, Vivek Rajagopal, Hassan Sayegh, Sara Mobasseri, Vibhav Rangarajan, Peter Flueckiger, Brandon Elliot, Matthew Brady, Shizhen Liu, Vinod Thourani, Mani Vannan
Journal: Journal of the American College of Cardiology (2021)
Potato trait development going fast-forward with genome editing
Authors: Per Hofvander, Erik Andreasson, Mariette Andersson
Journal: Trends in Genetics (2021)

Implementations and improvements of genome editing techniques used in plant science have increased exponentially. For some crops, such as potato, the use of transcription activator-like effector nucleases (TALEN) and clustered regularly interspaced short palindromic repeats (CRISPR) has moved to the next step of trait development and field trials, and should soon be applied to commercial cultivation.
Regulation of the NKG2D immunoreceptor by soluble mica during transcatheter arterial embolization for hepatocellular carcinoma
Authors: Kohga K, Takehara T, Hikita H, Sasakawa A, Uemura A, Sokamori R, Yamaguchi S, Tatsumi T, Ohkawa K, Kanto T, Hiromatu N, Katoyama K, Kato M, Hayashi N
Journal: Hepatology (2007)
BPI overexpression suppresses Treg differentiation and induces exosome-mediated inflammation in systemic lupus erythematosus
Authors: Huai-Chia Chuang, Ming-Han Chen, Yi-Ming Chen, Huang-Yu Yang, Yi-Ru Ciou, Chia-Hsin Hsueh, Ching-Yi Tsai, Tse-Hua Tan
Journal: Theranostics (2021)

Serum-derived exosomes are correlated with disease severity of human systemic lupus erythematosus (SLE). The proteins in the T-cell-derived exosomes from SLE patients could contribute to inflammation.