tbuckley/cabot-search huggingface dataset:
Ethics Considerations Regarding Artificial Womb Technology for the Fetonate
Authors: Felix R. De Bie, Sarah D. Kim, Sourav K. Bose, Pamela Nathanson, Emily A. Partridge, Alan W. Flake, Chris Feudtner
Journal: The American Journal of Bioethics (2022)

Since the early 1980's, with the clinical advent of in vitro fertilization resulting in so-called "test tube babies," a wide array of ethical considerations and concerns regarding artificial womb technology (AWT) have been described. Recent breakthroughs in the development of extracorporeal neonatal life support by means of AWT have reinitiated ethical interest about this topic with a sense of urgency. Most of the recent ethical literature on the topic, however, pertains not to the more imminent scenario of a physiologically improved method of neonatal care through AWT, but instead to the remote scenario of "complete ectogenesis" that imagines human gestation occurring entirely outside of the womb. This scoping review of the ethical literature on AWT spans from more abstract concerns about complete ectogenesis to more immediate concerns about the soon-to-be-expected clinical life support of what we term the fetal neonate or fetonate. Within an organizing framework of different stages of human gestational development, from conception to the viable premature infant, we discuss both already identified and newly emerging ethical considerations and concerns regarding AWT and the care of the fetonate.
Multi-crosslinking hydrogels with robust bio-adhesion and pro-coagulant activity for first-aid hemostasis and infected wound healing
Authors: Chen-Yu Zou, Xiong-Xin Lei, Juan-Juan Hu, Yan-Lin Jiang, Qian-Jin Li, Yu-Ting Song, Qing-Yi Zhang, Jesse Li-Ling, Hui-Qi Xie
Journal: Bioactive Materials (2022)
Screening for Anxiety in Adolescent and Adult Women
Authors: Tiffany I. Leung, Adam S. Cifu, Wei Wei Lee
Journal: JAMA (2022)

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INTO THE BRIGHT (AND THEN THE DARK): MULTIMODALITY IMAGING DIAGNOSIS OF MYOCARDIAL LIPOMATOUS METAPLASIA MASQUERADING AS LEFT VENTRICLE THROMBUS
Authors: Perry Wengrofsky, James Gubitosa, Phillip Lim, Tyler Soobryan, Pallavi Solanki, Alfonso H. Waller
Journal: Journal of the American College of Cardiology (2022)
A RARE CASE OF THROMBUS IN TRANSIT HANGING ON A COR TRIATRIATUM DEXTER MANAGED BY INTRACARDIAC ECHOCARDIOGRAPHY GUIDED PERCUTANEOUS ASPIRATION THROMBECTOMY
Authors: Akarsh Parekh, Anthony Teta, Anila Rao, Jay Mohan, Sibin K. Zacharias
Journal: Journal of the American College of Cardiology (2022)
Allergic airway recall responses require IL-9 from resident memory CD4 <sup>+</sup> T cells
Authors: Benjamin J. Ulrich, Rakshin Kharwadkar, Michelle Chu, Abigail Pajulas, Charanya Muralidharan, Byunghee Koh, Yongyao Fu, Hongyu Gao, Tristan A. Hayes, Hong-Ming Zhou, Nick P. Goplen, Andrew S. Nelson, Yunlong Liu, Amelia K. Linnemann, Matthew J. Turner, Paula Licona-Limón, Richard A. Flavell, Jie Sun, Mark H. Kaplan
Journal: Science Immunology (2022)

Asthma is a chronic inflammatory lung disease with intermittent flares predominately mediated through memory T cells. Yet, the identity of long-term memory cells that mediate allergic recall responses is not well defined. In this report, using a mouse model of chronic allergen exposure followed by an allergen-free rest period, we characterized a subpopulation of CD4+ T cells that secreted IL-9 as an obligate effector cytokine. IL-9-secreting cells had a resident memory T cell phenotype, and blocking IL-9 during a recall challenge or deleting IL-9 from T cells significantly diminished airway inflammation and airway hyperreactivity. T cells secreted IL-9 in an allergen recall-specific manner, and secretion was amplified by IL-33. Using scRNA-seq and scATAC-seq, we defined the cellular identity of a distinct population of T cells with a proallergic cytokine pattern. Thus, in a recall model of allergic airway inflammation, IL-9 secretion from a multicytokine-producing CD4+ T cell population was required for an allergen recall response.
COMPARISON OF EXTERNAL ILIAC ARTERY TO COMMON FEMORAL ARTERY SURGICAL ACCESS FOR TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Christopher Hatzis, Justin M. George, Lukas Ritzer, Nicole Ilonzo, Peter Cooke, Sahil Khera, Gilbert Hin-Lung Tang, Annapoorna Subhash Kini, Peter Faries, Rami Tadros
Journal: Journal of the American College of Cardiology (2022)
LONG-TERM IMPACT OF BETA-BLOCKERS FOR SECONDARY PREVENTION IN PATIENTS 60 YEARS OR OLDER WITHOUT PRIOR MYOCARDIAL INFARCTION OR REDUCED EJECTION FRACTION AFTER PERCUTANEOUS CORONARY INTERVENTION
Authors: Tatsuya Fukase, Tomotaka Dohi, Nishio Ryota, Mitsuhiro Takeuchi, Norihito Takahashi, Yuichi Chikata, Hirohisa Endo, Shinichiro Doi, Hiroki Nishiyama, Iwao Okai, Hiroshi Iwata, Shinya Okazaki, Katsumi Miyauchi, Hiroyuki Daida, Tohru Minamino
Journal: Journal of the American College of Cardiology (2022)
First Clinical Results of Fluorescence Lifetime-enhanced Tumor Imaging Using Receptor-targeted Fluorescent Probes
Authors: Rahul Pal, Marisa E. Hom, Nynke S. van den Berg, Thinzar M. Lwin, Yu-Jin Lee, Andrey Prilutskiy, William Faquin, Eric Yang, Srinivas V. Saladi, Mark A. Varvares, Eben L. Rosenthal, Anand T.N. Kumar
Journal: Clinical Cancer Research (2022)

Abstract Purpose: Fluorescence molecular imaging, using cancer-targeted near infrared (NIR) fluorescent probes, offers the promise of accurate tumor delineation during surgeries and the detection of cancer specific molecular expression in vivo. However, nonspecific probe accumulation in normal tissue results in poor tumor fluorescence contrast, precluding widespread clinical adoption of novel imaging agents. Here we present the first clinical evidence that fluorescence lifetime (FLT) imaging can provide tumor specificity at the cellular level in patients systemically injected with panitumumab-IRDye800CW, an EGFR-targeted NIR fluorescent probe. Experimental Design: We performed wide-field and microscopic FLT imaging of resection specimens from patients injected with panitumumab-IRDye800CW under an FDA directed clinical trial. Results: We show that the FLT within EGFR-overexpressing cancer cells is significantly longer than the FLT of normal tissue, providing high sensitivity (&amp;gt;98%) and specificity (&amp;gt;98%) for tumor versus normal tissue classification, despite the presence of significant nonspecific probe accumulation. We further show microscopic evidence that the mean tissue FLT is spatially correlated (r &amp;gt; 0.85) with tumor-specific EGFR expression in tissue and is consistent across multiple patients. These tumor cell-specific FLT changes can be detected through thick biological tissue, allowing highly specific tumor detection and noninvasive monitoring of tumor EFGR expression in vivo. Conclusions: Our data indicate that FLT imaging is a promising approach for enhancing tumor contrast using an antibody-targeted NIR probe with a proven safety profile in humans, suggesting a strong potential for clinical applications in image guided surgery, cancer diagnostics, and staging.
FEMALE-AUTHORED RESEARCH PUBLICATIONS IN HIGH-IMPACT CARDIOLOGY JOURNALS RECEIVE LESS ONLINE ATTENTION BASED ON ALTMETRIC SCORES
Authors: Kristen Brown, Lina Ya'qoub, Ridhima Goel, Joyce Njoroge, Laurette Mbuntum, Erika Squeri, Gleb Haynatzki, Roxana Mehran, Poonam Velagapudi, Dee Dee Wang, Martha Gulati
Journal: Journal of the American College of Cardiology (2022)
Addressing a crisis of generalizability with large-scale construct validation
Authors: Jessica Kay Flake, Raymond Luong, Mairead Shaw
Journal: Behavioral and Brain Sciences (2022)

Because of the misspecification of models and specificity of operationalizations, many studies produce claims of limited utility. We suggest a path forward that requires taking a few steps back. Researchers can retool large-scale replications to conduct the descriptive research which assesses the generalizability of constructs. Large-scale construct validation is feasible and a necessary next step in addressing the generalizability crisis.
Abstract P3-12-22: Socioeconomic position and prognosis in premenopausal breast cancer: A population-based cohort study in Denmark
Authors: Cathrine Hjorth, Per Damkier, Bent Ejlertsen, Timothy L Lash, Henrik T Sørensen, Deirdre Cronin-Fenton
Journal: Cancer Research (2022)

Abstract Background: To investigate how socioeconomic position (SEP) influences the effectiveness of cancer-directed treatment in premenopausal breast cancer patients in terms of breast cancer recurrence and mortality.Methods: Our cohort included all premenopausal women aged 18-55 years diagnosed with non-metastatic breast cancer and prescribed docetaxel-based chemotherapy in Denmark during 2007-2011. Population-based administrative registries provided data on SEP: marital status (married including registered partnership or single including divorced or widowed), cohabitation (cohabiting or living alone), education (low, intermediate or high), income (low, medium or high), and employment status (employed, unemployed or health-related absenteeism). For each SEP measure, we computed incidence rates, cumulative incidence proportions (CIPs) and used Poisson regression to compute incidence rate ratios and 95% confidence intervals (95% CIs) of recurrence and death. We stratified on ER status/tamoxifen to evaluate interaction.Results: Our cohort included 2,616 women; 286 (CIP: 13%) experienced recurrence and 223 (CIP: 11%) died during follow-up (median 6.6 and 7.2 years, respectively). Single women had both increased risks of recurrence (IRR: 1.45, 95% CI: 1.11-1.89) and mortality (IRR: 1.83, 95% CI: 1.32-2.52). Furthermore, we observed increased mortality in women with low education (IRR: 1.49, 95% CI: 0.95-2.33), low income (IRR: 1.37, 95% CI: 0.83-2.28), unemployment (IRR: 1.61, 95% CI: 0.83-3.13) or health-related work absenteeism (IRR: 1.80, 95% CI: 1.14-2.82), but smaller or no increased risk of recurrence. These findings were especially evident among women with ER+ tumors prescribed tamoxifen.Conclusions: Low SEP in premenopausal women with non-metastatic breast cancer was associated with increased mortality, but not always recurrence. This suggests underdetection of recurrences in certain groups. Poor prognosis in women with low SEP, especially single women, may partly be explained by tamoxifen adherence. Citation Format: Cathrine Hjorth, Per Damkier, Bent Ejlertsen, Timothy L Lash, Henrik T Sørensen, Deirdre Cronin-Fenton. Socioeconomic position and prognosis in premenopausal breast cancer: A population-based cohort study in Denmark [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P3-12-22.
Melanoma of the Palpebral Conjunctiva and Eyelid
Authors: Peng Zhang, Lian Chen
Journal: New England Journal of Medicine (2022)

A 47-year-old woman presented with eyelid itching and the sensation of a foreign body in her right eye. A pigmented mass was observed on the eyelid, and a large, pigmented lesion was observed on the palpebral conjunctiva on eyelid eversion. Excisional biopsy was performed, and a malignant melanoma was detected.
DATA-DRIVEN ATHEROSCLEROTIC PLAQUES PROFILES FROM QANGIO-CT ARE ASSOCIATED WITH FUNCTIONAL IMPAIRMENTS ASSESSED WITH PET-CT
Authors: Nilda Espinola-Zavaleta, Erick Alexanderson-Rosas, Enrique C. Guerra, Neftali E. Antonio-Villa, Leopoldo Perez de Isla
Journal: Journal of the American College of Cardiology (2022)
CORRELATION BETWEEN THE SINOTUBULAR JUNCTION AND THE AORTIC ANNULAR MEASUREMENTS BY COMPUTED TOMOGRAPHY ANGIOGRAPHY IN DETERMINING THE TRANSCATHETER AORTIC VALVE SIZE
Authors: Ashequl M. Islam, Khalid Sawalha, Mashrafi Ahmed, Karim Al-Azizi, Vinod Chaubey, Paul F. Visintainer
Journal: Journal of the American College of Cardiology (2022)
LDHA Desuccinylase Sirtuin 5 as a Novel Cancer Metastatic Stimulator in Aggressive Prostate Cancer
Authors: Oh Kwang Kwon, In Hyuk Bang, So Young Choi, Ju Mi Jeon, Ann-Yae Na, Yan Gao, Sam Seok Cho, Sung Hwan Ki, Youngshik Choe, Jun Nyung Lee, Yun-Sok Ha, Eun Ju Bae, Tae Gyun Kwon, Byung-Hyun Park, Sangkyu Lee
Journal: Genomics Proteomics & Bioinformatics (2022)

Prostate cancer (PCa) is the most commonly diagnosed genital cancer in men worldwide. Around 80% of the patients who developed advanced PCa suffered from bone metastasis, with a sharp drop in the survival rate. Despite great efforts, the detailed mechanisms underlying castration-resistant PCa (CRPC) remain unclear. Sirtuin 5 (SIRT5), an NAD+-dependent desuccinylase, is hypothesized to be a key regulator of various cancers. However, compared to other SIRTs, the role of SIRT5 in cancer has not been extensively studied. Here, we revealed significantly decreased SIRT5 levels in aggressive PCa cells relative to the PCa stages. The correlation between the decrease in the SIRT5 level and the patient's reduced survival rate was also confirmed. Using quantitative global succinylome analysis, we characterized a significant increase in the succinylation at lysine 118 (K118su) of lactate dehydrogenase A (LDHA), which plays a role in increasing LDH activity. As a substrate of SIRT5, LDHA-K118su significantly increased the migration and invasion of PCa cells and LDH activity in PCa patients. This study reveals the reduction of SIRT5 protein expression and LDHA-K118su as a novel mechanism involved in PCa progression, which could serve as a new target to prevent CPRC progression for PCa treatment.
What is exactly the problem with panpsychism?
Authors: Cyriel M. A. Pennartz
Journal: Behavioral and Brain Sciences (2022)

Abstract Merker et al.'s critique calls for a deeper analysis of panpsychism. In principle, the concept of integrated information can be applied to photodiodes and subatomic particles, but I suggest the main obstacle is the lack of any evidence to confirm the presence of consciousness. Also MRW's perspectivalist theory illustrates the difficulties in synthesizing a full-fledged theory of consciousness.
BRADEN SKIN SCORE ON ADMISSION PREDICTS IN-HOSPITAL AND 1-YEAR POST-DISCHARGE MORTALITY IN CARDIAC CARE UNIT PATIENTS: FIRST STUDY IN ASIAN POPULATION
Authors: Thanapon Nilmoje, Saranyou Suwanugsorn, Metus Thungthienthong, Wisanuwee Suriyaamorn, Ittipon Preechawettayakul, Ply Chichareon
Journal: Journal of the American College of Cardiology (2022)
ANTIARRHYTHMIC DRUG PRESCRIPTION: SOCIO-ECONOMIC DISPARITIES AFFECT MORTALITY AND HOSPITALIZATION
Authors: Abdel Hadi El Hajjar, Charbel Noujaim, Mario Mekhael, Yichi Zhang, Tarek Hassan Ayoub, Christopher Pottle, Chao Huang, Chan Ho Lim, Lilas Dagher, Nassir F. Marrouche
Journal: Journal of the American College of Cardiology (2022)
Post-Traumatic Epilepsy and Comorbidities: Advanced Models, Molecular Mechanisms, Biomarkers, and Novel Therapeutic Interventions
Authors: Victoria M. Golub, Doodipala Samba Reddy
Journal: Pharmacological Reviews (2022)

Post-traumatic epilepsy (PTE) is one of the most devastating long-term, network consequences of traumatic brain injury (TBI). There is currently no approved treatment that can prevent onset of spontaneous seizures associated with brain injury, and many cases of PTE are refractory to antiseizure medications. Post-traumatic epileptogenesis is an enduring process by which a normal brain exhibits hypersynchronous excitability after a head injury incident. Understanding the neural networks and molecular pathologies involved in epileptogenesis are key to preventing its development or modifying disease progression. In this article, we describe a critical appraisal of the current state of PTE research with an emphasis on experimental models, molecular mechanisms of post-traumatic epileptogenesis, potential biomarkers, and the burden of PTE-associated comorbidities. The goal of epilepsy research is to identify new therapeutic strategies that can prevent PTE development or interrupt the epileptogenic process and relieve associated neuropsychiatric comorbidities. Therefore, we also describe current preclinical and clinical data on the treatment of PTE sequelae. Differences in injury patterns, latency period, and biomarkers are outlined in the context of animal model validation, pathophysiology, seizure frequency, and behavior. Improving TBI recovery and preventing seizure onset are complex and challenging tasks; however, much progress has been made within this decade demonstrating disease modifying, anti-inflammatory, and neuroprotective strategies, suggesting this goal is pragmatic. Our understanding of PTE is continuously evolving, and improved preclinical models allow for accelerated testing of critically needed novel therapeutic interventions in military and civilian persons at high risk for PTE and its devastating comorbidities. <h3>Significance Statement</h3> Post-traumatic epilepsy is a chronic seizure condition after brain injury. With few models and limited understanding of the underlying progression of epileptogenesis, progress is extremely slow to find a preventative treatment for PTE. This study reviews the current state of modeling, pathology, biomarkers, and potential interventions for PTE and comorbidities. There's new optimism in finding a drug therapy for preventing PTE in people at risk, such as after traumatic brain injury, concussion, and serious brain injuries, especially in military persons.
IN-HOSPITAL OUTCOMES OF TRANSCATHETER AORTIC VALVE REPLACEMENT IN PATIENTS WITH CANCER
Authors: Mohamed Zghouzi, Waqas Ullah, Nada Elmakshbr, Chaitu Dandu, Heba Osman, Rashid Alhusain, Parveen Razvi, Abdul-Rahman M. Suleiman, Yasar Sattar, Wilson Hanna, M. Chadi Alraies
Journal: Journal of the American College of Cardiology (2022)
Abstract CS1-1: Oligometastatic disease: Definitions and practice patterns
Authors: Y Lievens
Journal: Cancer Research (2022)

Abstract Available evidence on oligometastatic disease (OMD) and its treatment, more in particular the use of metastasis directed radiotherapy (MDRT), mostly derives from retrospective, single-center series, with significant heterogeneity in patient inclusion criteria, definition of OMD, and outcomes reported. No molecular biomarker being clinically available for the identification of patients with true OMD, its diagnosis is typically based on imaging findings. However, the presentation on imaging may represent a whole range of different clinical scenarios, depending on the moment in the disease history, and the use - or not - of systemic therapy. Based on the available data, consensus was reached amongst radiation oncology experts representing ASTRO and ESTRO, that OMD can to date be defined as 1-5 metastatic lesions, both occurring synchronously or metachronously, in which a controlled primary tumor is considered optional but with as prerequisite that all metastatic sites must be safely treatable. Moreover, in a collaboration between the ESTRO and EORTC, subclassification into oligorecurrence, oligoprogression, and oligopersistence was suggested, depending on whether OMD is diagnosed during a treatment-free interval or during active systemic therapy and whether or not an oligometastatic lesion is progressing on current imaging.While further evidence is being generated in (randomized) clinical trials as well as through collecting real-world data from clinical practice, it is imperative to use consistent definitions and reporting to further refine and validate the OMD classification and nomenclature, and to acquire a better understanding of the true impact of MDRT in different clinical scenarios. Citation Format: Y Lievens. Oligometastatic disease: Definitions and practice patterns [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr CS1-1.
TRANSCATHETER AORTIC VALVE REPLACEMENT FOR THE TREATMENT OF LEFT VENTRICULAR ASSIST DEVICE-RELATED AORTIC REGURGITATION
Authors: Keerthi Gondi, Marty Tam, Stanley J. Chetcuti, Francis D. Pagani, Paul Michael Grossman, G. Michael Deeb, Daniel S. Menees, Jonathan Haft, Himanshu J. Patel, Keith D. Aaronson, Devraj Sukul
Journal: Journal of the American College of Cardiology (2022)
A facile and general method for synthesis of antibiotic-free protein-based hydrogel: Wound dressing for the eradication of drug-resistant bacteria and biofilms
Authors: Jiang Ouyang, Qingyue Bu, Na Tao, Mingkai Chen, Haijun Liu, Jun Zhou, Jinggong Liu, Bo Deng, Na Kong, Xingcai Zhang, Tianfeng Chen, Yihai Cao, Wei Tao
Journal: Bioactive Materials (2022)