tbuckley/cabot-search huggingface dataset:
Abstract 12330: Effects of Diabetes on Left Ventricular Diastolic Dysfunction in Patients with Hypertension; A Substudy of Calvloc Study
Authors: Katsuomi Iwakura, Hiroshi Ito, Motoo Date, Katsuhisa Ishii, Fumiaki Nakamura, Toshihiko Nagano, Shin Takiuchi, Kei Tawarahara, Mikio Mukai, Masanori Shinoda, Taro Minagawa, Naoki Goto
Journal: Circulation (2011)

Background: Coexistence of diabetes mellitus (DM) worsens prognosis of hypertensive patients, but its mechanisms are still not fully elucidated. We previously performed a multicenter trial (CALVLOC...
Chronological Analysis of Clonal Evolution in Acquired Aplastic Anemia
Authors: Tetsuichi Yoshizato, Bogdan Dumitriu, Kohei Hosokawa, Hideki Makishima, Kenichi Yoshida, Aiko Sato, Yusuke Okuno, Keisuke Kataoka, Kenichi Chiba, Hiroko Tanaka, Yuichi Shiraishi, Yasunobu Nagata, Hiromichi Suzuki, Yusuke Sato, Yusuke Shiozawa, Takamasa Katagiri, Ayana Kon, Michael Clemente, Masashi Sanada, Satoru Miyano, Jaroslaw P. Maciejewski, Shinji Nakao, Neal S. Young, Seishi Ogawa
Journal: Blood (2014)
Abstract 005: Prevalence, Awareness, Treatment, and Control of Hypertension in China: The China Metabolic Risk Factor Study
Authors: Yu Xu, Yufang Bi, Mian Li, Weiqing Wang, Tiange Wang, Limin Wang, Yong Jiang, Min Xu, Jieli Lu, Jianhong Li, Shengquan Mi, Chung-Shiuan Chen, Linhong Wang, Jiajun Zhao, Yiming Mu, Guangwei Li, Jiang He, Jialun Chen, Lingzhi Kong, Wenhua Zhao, Guang Ning
Journal: Circulation (2013)

Objective: Hypertension is the leading preventable risk factor for premature death in the world. We estimated the prevalence and distribution of hypertension and determined the status of hypertension awareness, treatment, and control in the general population in China. Methods: We conducted a cross-sectional survey in a nationally representative sample of 98,658 Chinese adults aged ≥18 years in 2010. Three blood pressure (BP) measurements were obtained by trained observers using a calibrated automatic electronic device (OMRON Model HEM-7071) after a 5-minute sitting rest. Information on history of hypertension and use of antihypertensive medications was obtained by use of a standard questionnaire. Hypertension was defined as a mean systolic BP ≥140 mm Hg and/or diastolic BP ≥90 mm Hg and/or use of antihypertensive medications. Prevalence of hypertension was calculated by weighting sampling factors derived from China population census data in 2010 to obtain national estimates. Results: An estimated total o...
CONSTRICTIVE PERICARDITIS
Authors: 幸一 紀, 一志 久間, 英生 古田, 俊二 佐野, 雅春 重信, 泰治 村上, 俊爾 川上, 清人 名和, 嘉昌 妹尾, 滋 寺本
Journal: The Lancet (1983)
Abstract 19696: Hypertension and Elevated hs-CRP Predict Occult Cardiovascular Disease in Asymptomatic Survivors of Hodgkin's Lymphoma Treated with Chest Radiation
Authors: Ming Hui Chen, Andrea K Ng, Jing Zhou, Kimberlee Gauvreau, Peter Mauch
Journal: Circulation (2012)

Background: Cardiovascular disease (CVD) is the leading cause of mortality in Hodgkin’s lymphoma (HL) survivors treated with chest radiation therapy (RT). The contribution of traditional cardiovascular risk factors (CRFs) to CVD development in this irradiated population is unclear since most studies are retrospective. Methods: Two hundred and ten asymptomatic HL survivors treated with RT at 3 Harvard hospitals were recruited and assessed for treatment- and patient-related CRFs. Each patient underwent an outpatient cardiology visit and laboratory testing. Blood pressure (BP) measurement, electrocardiogram, and resting and stress echocardiography were performed. CVD detected on screening was correlated with patient-related CRFs. Results: One hundred eighty-two HL survivors (59% female, mean age 44.1 ± 8.7 years, follow-up time 15.1 ± 7.2years) completed cardiac screening and formed the cohort. 81% of patients had ≥ 1 modifiable CRF. 26% (47) of patients (53% female, mean age 45.3 ± 9.0 years, follow-up time 16.9 ± 8.3 years) had occult coronary artery disease (CAD), at least moderate valve disease, or left ventricular systolic dysfunction (LVSD). Hypertension (OR=4.9, p=0.0003), elevated high-sensitivity C-reactive protein (hs-CRP) (OR=2.9, p=0.01), and older age (OR= 1.1, p=0.006) were correlated with CAD/valve disease. LVSD was not correlated with patient CRFs. For every 5mmHg decrease in systolic BP or in diastolic BP, the odds of CAD/valve disease decrease 22% or 26% respectively. Conclusions: This is one of the most comprehensive prospective assessments of CRFs in HL survivors. Hypertension and hs-CRP are common and sensitive markers of CAD/valve disease in asymptomatic survivors treated with chest RT, and may allow better identification of those with occult CVD treated with chest radiation.
The Nervous Housewife.
Authors: Abraham Myerson
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Interaction of microbes with mucus and mucins
Authors: Julie Naughton, Gina Duggan, Billy Bourke, Marguerite Clyne
Journal: Gut Microbes (2013)

Due to the recent rapid expansion in our understanding of the composition of the gut microflora and the consequences of altering that composition the question of how bacteria colonise mucus layers and interact with components of mucus, such as mucin, is now receiving widespread attention. Using a combination of mucus secreting cells, and a novel mucin microarray platform containing purified native mucins from different sources we recently demonstrated that two gastrointestinal pathogens, Helicobacter pylori and Campylobacter jejuni, colonise mucus by different mechanisms. This result emphasizes the potential for even closely related bacteria to interact with mucus in divergent ways to establish successful infection. Expanding the use of the mucin arrays described in the study to other microorganisms, both pathogenic and commensal, should lead to the discovery of biologically important motifs in bacterial-host interactions and complement the use of novel in vitro cell models, such as mucus secreting cell lines.
The Effect of Carcinogenic Hydrocarbons and Related Compounds on the Autoxidation of Oils
Authors: H. F. Deutsch, D. L. Miner, H. P. Rusch
Journal: Cancer Research (1941)

The theory that the carcinogenic hydrocarbons might exert an influence on the tissues by affecting the lipid part of the cell is suggested by the fact that these compounds are insoluble in water but are soluble in most fats and fat solvents. However, very little is known regarding the cellular metabolism of fats, and it is difficult to find a satisfactory system on which to test this theory. One possible mode of action of the carcinogens on fat metabolism might be through their effect on phospholipid oxidation. Rusch and Kline (6) have demonstrated that the oxidation of phospholipids in the presence of glutathione, cysteine, ascorbic acid, thiamin, riboflavin, or pyridoxine can be inhibited by carcinogenic chemicals. It is not known, however, whether the antioxygenic action of the carcinogens is specific for catalyzed phospholipid oxidation or whether other types of fat oxidation are also affected by the hydrocarbons. Accordingly, the following experiments were designed to determine the effect of the carcinogenic chemicals and related compounds on the autoxidation of fats.
Abstract 15154: Interaction of Krueppel-Like Factor (klf) 15 and Wnt-Signaling Pathway and its Role in Adult Cardiac Precursor Cell Regulation
Authors: Claudia Noack, Anke Renger, Maria-Patapia Zafiriou, Rainer Dietz, Hans-Jörg Schäffer, Martin Bergmann, Laura Zelarayan
Journal: Circulation (2011)

Wnt/β-catenin signaling controls early cardiac development as well as adult heart remodeling in part via regulation of cardiac progenitor cell (CPC) differentiation. We characterized the effect of ...
Cost-Effectiveness Of Antithrombin Repletion In Adult Patients With Acute Lymphoblastic Leukemia (ALL) Treated With Asparaginase-Containing Combination Chemotherapy; A Single Center Experience
Authors: Kristen B. McCullough, Jason N. Barreto, Candy S Peskey, Dennis A. Gastineau, Michelle Elliott, Naseema Gangat, Mrinal M Patnaik, Mark R. Litzow, William J Hogan
Journal: Blood (2013)
Infradiaphragmatic Hodgkin Lymphoma In Patients Treated With State-Of-The-Art Therapies: A Risk Factor Analysis From The German Hodgkin Study Group (GHSG) HD13 and HD14 Trials
Authors: Bastian von Tresckow, Helen Görgen, Annette Plütschow, Boris Böll, Dennis A. Eichenauer, Stephanie Sasse, Achim Rothe, Michael Fuchs, Karolin Behringer, Andreas Engert, Peter Borchmann
Journal: Blood (2013)
Therapeutic Approach to Advanced Follicular Lymphoma at Diagnosis: An Argentinian Survey
Authors: German R. Stemmelin, Marta Dragosky, Adriana Vitriu, maria Julia Caffaro, Miguel A Pavlovsky, Marisa Marquez, Astrid Pavlovsky, Dardo Alberto Riveros, Lucia Zoppegno, Rivas maria Marta, Garatte Gonzalo, Georgina Bendek, Marta Zerga, Andrea Rodriguez, Susana Cerana, Diego Fernandez, Maria amoroso Copello, Graciela Alfonso, Virginia Canonico, Mercedes Gomez, Emilio Lanari, Claudio d'Antonio, Florencia Baglioni, Sebastian Prieto, Silvina Palmer, Daniel Gotta, Isabel Cristina Annetta, Norma E. Tartas
Journal: Blood (2014)
Abstract 2458: Atorvastatin Reduces Sympathetic Activity in Hypertensive Patients
Authors: Marc E Gomes, Cees J Tack, Freek W Verheugt, Paul Smits, Jacques W Lenders
Journal: Circulation (2008)

Background In hypertension, a state of increased (central) sympathetic activity exists. This high sympathetic activity is associated with worse prognosis and refractoriness to pharmacological interventions. Animal experimental data suggest that HMG CoA reductase inhibitors (statins) can reduce sympathetic activity at a central level. We hypothesized that atorvastatin 80 mg/day could reduce sympathetic activity in human patients with hypertension. Methods Using a prospective, randomized, placebo-controlled, double-blind, cross-over design, patients were randomly assigned to atorvastatin 80 mg/day or placebo, for 3 weeks. Sympathetic nervous system activity was measured at the end of each treatment period, in 13 patients with mild to moderate hypertension by microneurography for direct muscle sympathetic nerve recording (MSNA) and plasma norepinephrine concentrations. Effects on blood pressure were assessed by 24 hour ambulatory blood pressure measurement. Results Atorvastatin significantly reduced MSNA (atorvastatin: 58.5±2.0 vs. placebo: 64.7±3.0 bursts/100 beats, P=0.02). Although MSNA values and plasma cholesterol levels were correlated, reduction in MSNA was independent of the degree of reduction in plasma cholesterol. Atorvastatin had no effect on plasma norepinephrine levels nor on daytime and night time blood pressure. Conclusion: In patients with mild to moderate hypertension, atorvastatin treatment reduces central sympathetic nervous outflow. This finding supports the concept that HMG CoA reductase regulates sympathetic nervous system activity at the central level and indicates a sympathoinhibitory role for atorvastatin in human hypertensive patients.
Impact of Intensive Lifestyle and Metformin Therapy on Cardiovascular Disease Risk Factors in the Diabetes Prevention Program
Authors: Robert Ratner, Ronald Goldberg, Steven Haffner, Santica Marcovina, Trevor Orchard, Sarah Fowler, Marinella Temprosa
Journal: Diabetes Care (2005)

OBJECTIVE—The Diabetes Prevention Program demonstrated the ability to delay or prevent type 2 diabetes in participants with impaired glucose tolerance (IGT). Participants with IGT are at high risk for cardiovascular disease (CVD), with a marked increase in the number and severity of CVD risk factors. We prospectively assessed the impact of our interventions on hypertension, dyslipidemia, and CVD events. RESEARCH DESIGN AND METHODS—The study group consisted of 3,234 individuals with IGT randomly assigned to receive intensive lifestyle intervention, metformin, or placebo. Annual assessment of blood pressure, lipids, electrocardiogram, and CVD events was undertaken. RESULTS—Hypertension was present in 30% of participants at study entry and then increased in the placebo and metformin groups, although it significantly decreased with intensive lifestyle intervention. Triglyceride levels fell in all treatment groups, but fell significantly more with intensive lifestyle intervention. Total cholesterol and LDL cholesterol levels were similar among treatment groups. Intensive lifestyle intervention significantly increased the HDL cholesterol level and reduced the cumulative incidence of the proatherogenic LDL phenotype B. At 3 years of follow-up, the use for pharmacologic therapy to achieve established goals in the intensive lifestyle group was 27–28% less for hypertension and 25% less for hyperlipidemia compared with placebo and metformin groups. Over an average of 3 years, 89 CVD events from 64 participants were positively adjudicated studywide, with no differences among treatment groups. CONCLUSIONS—Lifestyle intervention improves CVD risk factor status compared with placebo and metformin therapy. Although no differences in CVD events were noted after 3 years, achieved risk factor modifications suggest that longer intervention may reduce CVD event rates.
Abstract 12180: Effectiveness of Nicorandil, a K-ATP Channel Opener, Against Contrast-Induced Nephropathy After Percutaneous Coronary Intervention in Patients with Poor Renal Function
Authors: Takahide Nawa, Kazuhiko Nishigaki, Arihiro Hattori, Takuma Aoyama, Masanori Kawasaki, Shinya Minatoguchi
Journal: Circulation (2011)

Background: Contrast-induced nephropathy (CIN) has become a significant source of hospital morbidity and mortality due to the ever-increasing use of iodinated contrast media with percutaneous coron...
Impaired Generation of Bone Marrow B Lymphocytes in Mice Deficient in C/EBPβ
Authors: Xueni Chen, Weimin Liu, Concetta Ambrosino, Maria R. Ruocco, Valeria Poli, Luigina Romani, Ileana Quinto, Susan Barbieri, Kevin L. Holmes, Salvatore Venuta, Giuseppe Scala
Journal: Blood (1997)
NHS Direct
Authors: S. Kempley
Journal: BMJ (2000)

NHS Direct Doctors may gain time to use their true skills if people start using NHS DirectEditor-O'Cathain et al's paper confirming that advice offered by nurses through NHS Direct was useful to callers 1 should make us question the generally hostile opinions on this service propounded in free publications that derive their income from pharmaceutical advertising. 2elephone advice can form an important part of an NHS that needs to meet people's concerns, even if some of these concerns seem trivial to doctors working under pressure.The primary end point of NHS Direct should be whether it meets the needs of its callers for information not whether it reduces work for any sector of the medical profession.If an increasingly information hungry population cannot get information from the NHS it will turn to other sources, which may be less reliable or relevant.Too often, medical staff see their role as tough gatekeepers of the NHS, excluding a public that would demand too much.This demeans the public and those working in the front line of the NHS.If the NHS develops several different front doors doctors may be freed to use their skills without waging a continual battle to persuade members of the public that they do not need further investigation, treatment, or referral.
The Mutational Status Of Genes Involved In DNA Repair and Folate Pathway Predicts Overall Survival Of Patients With Low-Risk, Untreated Myelodysplastic Syndrome
Authors: Alessandro Isidori, Annamaria Ruzzo, Federica Loscocco, Maria Teresa Voso, Francesco Graziano, Sara Barulli, Emanuele Canestrari, Antonio Volpe, Domenico Magro, Pier Paolo Piccaluga, Fabio Fuligni, Stefania Paolini, Teresa Ricciardi, Paola Picardi, Elisa Giacomini, Marco Rocchi, Mauro Magnani, Giuseppe Visani
Journal: Blood (2013)
Indian rotavirus vaccine concern over intussusception is unfounded, say researchers
Authors: P. Pulla
Journal: BMJ (2015)

Researchers testing an Indian rotavirus vaccine have said that concerns linking it to an increased risk of intussusceptions are unfounded. They were responding to an online campaign that has called for them to release raw data on the rates of intussusception seen during the trial.1 

Gagandeep Kang, professor of gastrointestinal sciences at Christian Medical College, Vellore, who worked on the trial, said that the trial data cannot be used to estimate the risk of intussusception from the vaccine as the campaigners have argued. “This was not a study powered to detect rare events. If you want to find the rate of intussusception, you need to evaluate the vaccine in hundreds of thousands of children,” she told The BMJ .

Kang’s group conducted the trial in 6800 children to measure the efficacy of the Indian rotavirus vaccine, Rotavac, which was developed by the Hyderabad based company Bharat Biotech and tested with funding from India’s Department of Biotechnology. During the two year trial Kang’s team also collected data on intussusception, a rare side effect in which the intestine folds into itself, …
Failure to diagnose acute myocardial infarction
Authors: Sara Bird
Journal: JAMA (1984)

Case histories are based on actual medical negligence claims, however, certain facts have been omitted or changed by the author to ensure the anonymity of the parties involved. An allegation of failure to diagnose acute myocardial infarction is a relatively common cause of medical negligence claims against general practitioners. The main factors contributing to these claims are failure to order appropriate investigations (including electrocardiograms), failure to suspect myocardial infarction, failure or delay in hospital admission and/or referral and misinterpretation of investigations. This article outlines risk management strategies for GPs to minimise the possibility of a claim arising from the failure to diagnose acute myocardial infarction.
Abstract 3892: Persistent Impairment of Endothelial Vasomotor Function Has an Adverse Effect on Long-term Outcomes in Patients With Chronic Ischemic Heart Failure
Authors: Isao Takishima, Yoshinobu Kitta, Mitsumasa Hirano, Takamitsu Nakamura, Kiyotaka Kugiyama
Journal: Circulation (2009)
Artificial Light and Photography: A Treatise on Artificial Light Sources and Their Application in Photography.
Authors: Gerard Daniel Rieck, Leo Henricus Verbeek, G. Ducloux
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anti-CCP antibodies and IGA-rheumatoid factor predict the development of rheumatoid arthritis
Authors: Solbritt Rantapää Dahlqvist, B A W De Jong, E Berglin, G Hallmans, G Wadell, H Stenlund, U Sundin
Journal: Annals of the Rheumatic Diseases (2003)

Anti-CCP antibodies and IGA-rheumatoid factor predict the development of rheumatoid arthritis
関節リウマチ(RA)臨床試験におけるX線画像上の進行評価の測定誤差: 検出可能最小変化(SDC)の再検討
Authors: Navarro-Compan, Van Der Heijde D, Ahmad Harris A, Miller Colin G, Wolterbeek R, Landewe R
Journal: Annals of the Rheumatic Diseases (2014)
Splanchnic Vein Thrombosis Associated With Myeloproliferative Neoplasms. A Study Of The IWG-MRT In 475 Subjects
Authors: Lisa Pieri, Paola Guglielmelli, Massimo Primignani, Cecilia Brambilla, Maria Luigia Randi, Claudia Santarossa, Mario Cazzola, Elisa Rumi, Francisco Cervantes, Martin Ellis, Frederick Chen, Dhiraj Tripathi, Neil Rajoriya, Tiziano Barbui, Federica Delaini, Valerio De Stefano, Elena Rossi, Silvia Betti, Giorgina Specchia, Alessandra Ricco, Heinz Gisslinger, Bettina Gisslinger, Nicola Vianelli, Nicola Polverelli, Marco Ruggeri, Francois Girodon, Ayalew Tefferi, Alessandro M Vannucchi
Journal: Blood (2013)