Oral Pharmacologic Treatment of Type 2 Diabetes Mellitus
Authors: Silvio E. Inzucchi, Mikhail Kosiborod
Journal: Annals of Internal Medicine (2017)

Letters4 July 2017Oral Pharmacologic Treatment of Type 2 Diabetes MellitusSilvio E. Inzucchi, MD and Mikhail Kosiborod, MDSilvio E. Inzucchi, MDFrom Yale School of Medicine and Yale—New Haven Hospital, New Haven, Connecticut, and Saint Luke's Mid America Heart Institute and University of Missouri—Kansas City, Kansas City, Missouri.Search for more papers by this author and Mikhail Kosiborod, MDFrom Yale School of Medicine and Yale—New Haven Hospital, New Haven, Connecticut, and Saint Luke's Mid America Heart Institute and University of Missouri—Kansas City, Kansas City, Missouri.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L17-0231 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read with great anticipation Qaseem and colleagues' (1) update of the American College of Physicians' clinical practice guideline on oral therapy in type 2 diabetes. However, as with the first iteration of this well-considered set of recommendations in 2012, the authors continue to focus predominantly on control of hemoglobin A1c levels. Although this has been the raison d'être of diabetes therapy for decades, data amassed over the past 1 to 2 years will probably change such a traditional approach, particularly as it relates to the prevention of cardiovascular death and other adverse sequelae of cardiovascular disease ...References1. Qaseem A, Barry MJ, Humphrey LL, Forciea MA; Clinical Guidelines Committee of the American College of Physicians. Oral pharmacologic treatment of type 2 diabetes mellitus: a clinical practice guideline update from the American College of Physicians. Ann Intern Med. 2017;166:279-90. [PMID: 28055075]. doi:10.7326/M16-1860 LinkGoogle Scholar2. Zinman B, Wanner C, Lachin JM, Fitchett D, Bluhmki E, Hantel S, et al; EMPA-REG OUTCOME Investigators. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med. 2015;373:2117-28. [PMID: 26378978] doi:10.1056/NEJMoa1504720 CrossrefMedlineGoogle Scholar3. Kernan WN, Viscoli CM, Furie KL, Young LH, Inzucchi SE, Gorman M, et al; IRIS Trial Investigators. Pioglitazone after ischemic stroke or transient ischemic attack. N Engl J Med. 2016;374:1321-31. [PMID: 26886418] doi:10.1056/NEJMoa1506930 CrossrefMedlineGoogle Scholar4. Marso SP, Daniels GH, Brown-Frandsen K, Kristensen P, Mann JF, Nauck MA, et al; LEADER Steering Committee. Liraglutide and cardiovascular outcomes in type 2 diabetes. N Engl J Med. 2016;375:311-22. [PMID: 27295427] doi:10.1056/NEJMoa1603827 CrossrefMedlineGoogle Scholar5. Marso SP, Bain SC, Consoli A, Eliaschewitz FG, Jódar E, Leiter LA, et al; SUSTAIN-6 Investigators. Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med. 2016;375:1834-44. [PMID: 27633186] MedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Yale School of Medicine and Yale—New Haven Hospital, New Haven, Connecticut, and Saint Luke's Mid America Heart Institute and University of Missouri—Kansas City, Kansas City, Missouri.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L17-0231. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoOral Pharmacologic Treatment of Type 2 Diabetes Mellitus: A Clinical Practice Guideline Update From the American College of Physicians Amir Qaseem , Michael J. Barry , Linda L. Humphrey , Mary Ann Forciea , and Oral Pharmacologic Treatment of Type 2 Diabetes Mellitus David S.H. Bell Oral Pharmacologic Treatment of Type 2 Diabetes Mellitus Michael J. Barry , Linda L. Humphrey , and Amir Qaseem Metrics 4 July 2017Volume 167, Issue 1Page: 73-74KeywordsCardiovascular diseasesGlucoseHeart failureHospitalizationsIschemic strokeMortalityMyocardial infarctionQuality of lifeTreatment guidelinesType 2 diabetes ePublished: 4 July 2017 Issue Published: 4 July 2017 Copyright & PermissionsCopyright © 2017 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...