tbuckley/cabot-search huggingface dataset:
The panic-agoraphobic spectrum: a descriptive approach to the assessment and treatment of subtle symptoms
Authors: G B Cassano, S Michelini, M K Shear, E Coli, J D Maser, E Frank
Journal: American Journal of Psychiatry (1997)

Psychiatric classification is still a topic of considerable discussion and debate in spite of major advances in the past two decades. The debate involves categorical versus dimensional approaches, cutoff numbers of symptoms to define a case, degree of impairment, objective diagnostic criteria versus more theoretically based criteria, episodic versus trait-like symptoms, and the role of atypical and subclinical symptoms. All of these issues have been raised for the anxiety disorders and depression. This article presents the conceptualization of a relatively novel and testable approach to the diagnosis and classification of panic and agoraphobia, the panic-agoraphobic spectrum, and pilot data on a new questionnaire to assess it.Pilot testing of the Panic-Agoraphobic Spectrum Questionnaire was undertaken with 100 inpatients who had lifetime diagnoses of panic disorder, unipolar depression, comorbid panic and unipolar depressive disorders, or an eating disorder. The instrument emphasizes impairment related to 144 behaviors and experiences in seven panic-agoraphobic symptom domains.Patients with panic disorder scored highest on the questionnaire, and those with comorbid depression showed even greater severity of illness. The scores of the patients with eating disorders and of the depressed patients differed from those of the other groups but also differed from 0.The spectrum model of panic and agoraphobia is a flexible and comprehensive means of describing this clinical complex. The proposed model, complementary to the categorical approach, presumably expresses a unitary pathophysiology. Its usefulness is discussed in terms of its value for patient-therapist communication, outcome measures, identification of subtle personality traits, and subtyping of patients for research and treatment.
冠心病的药物治疗、经皮冠状动脉介入术和冠状动脉旁路移植术？三种方法应互为补充而非互相竞争
Authors: Andre, Lamy, Madhu, Natarajan, Salim, Yusuf, 孟丽, 高润霖
Journal: BMJ (2011)

过去十年，随着他汀类药物、有效的降压药（特别是血管紧张素转换酶抑制剂，ACEI）、钙拮抗剂和抗血小板药物的使用，冠心病的药物治疗疗效已经有了改善。此外，经皮冠状动脉介入术（PCI，包括直接PCI和补救性PCI）的进步已使急性心肌梗死。
Abstract 4191: Impact of Proximal Balloon Occlusion on the Measurement of Luminal Size and Fibrous Cap Thickness by Optical Coherence Tomography
Authors: Takao Sato, Tomoki Kameyama, Takahisa Noto, Hiroshi Inoue
Journal: Circulation (2009)

Background: Optical coherence tomography (OCT) provides accurate measurement of coronary lumen diameter and fibrous cap thickness in vivo. Because OCT requires blood-free zone for imaging, low pressure (−0.5atm) proximal balloon occlusion (PBO) combined with distal flush (0.5–2ml/sec) from the tip of the catheter or bolus injection (2.5– 4ml/sec) of crystalloid fluid through the guiding catheter without PBO is performed during OCT imaging. The purpose of this study was to investigate the effect of PBO on the assessment of the lumen size and the fibrous cap thickness by OCT in patients.  Methods: We performed OCT with and without PBO in 14 patients. The lumen diameter (LD), the lumen cross sectional area (CSA) and the minimal fibrous cap thickness (FCT) were compared between 40 lesion pairs. Presence of the calcified plaque in each lesion was also evaluated. In 5 patients, intracoronary pressure with and without PBO was compared using the pressure wire.  Results: With PBO, intracoronary pressure was diminished from 75.5±29.5 to 19.8±2.9 mmHg (p  Conclusion: The presence of proximal balloon occlusion influences lumen size and fibrous cap thickness assessed by OCT. The differences are further affected by the plaque morphology.
Conjunctival Melanoma
Authors: Colin W McInnes, Lorne Bellan
Journal: New England Journal of Medicine (2015)

A 78-year-old woman with a history of glaucoma, diabetes, and cataracts presented with an erythematous and brown maculopapular lesion in her right eye. She reported that it had been present for about 1 year, during which time it had fluctuated in size and bled occasionally.
Imported human African trypanosomiasis in Europe, 2005-2009
Authors: P Gautret, J Clerinx, E Caumes, F Simon, M Jensenius, L Loutan, P Schlagenhauf, F Castelli, D Freedman, A Miller, U Bronner, P Parola, Collective for EuroTravNet
Journal: Eurosurveillance (2009)

Physicians in Europe are likely to see more African trypanosomiasis cases because of the increasing popularity of travel to Africa. In this paper the literature on imported cases in Europe, since 2005 is reviewed. Because of the high mortality risk associated with acute Rhodesian trypanosomiasis, travellers should be informed about preventive measures and the early disease manifestations.
Reduced frontal cortex inositol levels in postmortem brain of suicide victims and patients with bipolar disorder
Authors: H Shimon, G Agam, R H Belmaker, T M Hyde, J E Kleinman
Journal: American Journal of Psychiatry (1997)

This study aimed to evaluate aspects of second messenger function in the brain of suicide victims and patients with bipolar disorder.Inositol and its synthetic enzyme, inositol monophosphatase, were measured in postmortem brain samples of 10 suicide victims, eight patients with bipolar affective disorder, and 10 normal comparison subjects.The frontal cortex inositol levels of the suicide victims and the patients with bipolar disorder were significantly less than those of the normal comparison group. No differences in cerebellum or occipital cortex inositol levels were found among the three groups. The groups also showed no differences in inositol monophosphatase activity in any brain area.These results could suggest a deficiency of second messenger precursor in patients with bipolar disorder and suicide victims.
ALK+ Lymphoma: Clinico-Pathological Findings and Outcome
Authors: Brunangelo Falini, Stefano Pileri, Pier Luigi Zinzani, Antonino Carbone, Vittorina Zagonel, Chris Wolf-Peeters, Gregor Verhoef, Fabio Menestrina, Giuseppe Todeschini, Marco Paulli, Mario Lazzarino, Roberta Giardini, Antonella Aiello, Hans Dieter Foss, Iguacyra Araujo, Marco Fizzotti, Pier Giuseppe Pelicci, Leonardo Flenghi, Massimo F. Martelli, Antonella Santucci
Journal: Blood (1999)
HENVINET portal: A platform for collaboration between environmental health and oncology in preventing and treating cancer.
Authors: A. Fucic, F. Merlo, M. Gamulin, Z. Ferencic, A. Bartonova
Journal: Journal of Clinical Oncology (2010)

e12053 Background: Environmental health cancer research is focused on the relationship between agents from living and occupational environment and cancer. Oncology in turn treats subjects with cancers caused by carcinogens. However, data on these subjects, collected during diagnostics and therapy, are not communicated to environmental health. One of the reasons may be uncertain etiology of a number of cancers, but the other is weak collaboration between environmental health and oncology professionals. Unlike a few decades ago, when scientific and professional methods differed between the two fields, today both apply similar biomarkers and tools (SNPs, genotoxicology methods, developmental biomarkers, estrogen levels, sex differences, systems biology). Methods: Within the project Health and Environment Network, the European Commission has developed an Internet portal at www.henvinet.eu which covers diseases related to environmental exposures such as asthma, endocrine disruptors, and cancer. For the first time, the portal has posted cause-effect for cancer, using principal of complexity bringing together all known physical and chemical parameters which may play a role in cancerogenesis, including genetic predisposition, enzyme polymorphisms, family cancer history, and statistical relevance, all supported by references and a dictionary. Results: The portal is intended as an interactive platform which enables direct communication between experts and interest groups. Information are given in short, condensed form and allow every portal visitor to share their own information. Conclusions: The portal has a potential to link environmental health and oncology and bring new quality to both fields through more efficient application of biomarkers, new strategies in drug development, resulting from new insights in the interaction mechanisms between environmental carcinogens and the cell, more efficient application of databases from both fields in order to improve treatment, oncology participation in cancer preventive activities and cancer patient therapy on individual basis, taking into account individual environmental radiochemical exposure (Funded: HENVINET EC037019). No significant financial relationships to disclose.
Methicillin-resistant Staphylococcus aureus among players on a high school football team - New York City, 2007.
Authors: P. Kellner, A. Yeung, H. A. Cook, J. Kornblum, M. Wong, F. Eniola, D. Weiss, H. P. Nair
Journal: MMWR Morbidity and Mortality Weekly Report (2009)
Banning smoking would not stop people from buying cigarettes
Authors: D. Cashman
Journal: BMJ (1996)

Telling patients there is nothing wrong Randomised controlled trials are needed EDrroR,-It is still unclear from the literature whether investigative tests reassure patients with anxieties about the presence of serious disease.' 2 Ray Fitzpatrick discusses some of the possible reasons for this, including psychiatric morbidity, poor communication, and the "wild card effects" mentioned in the study by I G McDonald and colleagues.3Other psychological processes in patients are
Abstract 13061: Vascular Smooth Muscle Cell-selective O-GlaNAcylation Protects Arteries Against Acute Injury
Authors: Dongqi Xing, Wenguang Feng, Fadi Hage, Andrew J Paterson, John C Chatham, Suzanne Oparil
Journal: Circulation (2013)

BACKGROUND: We previously demonstrated that acutely increasing protein O-GlcNAcylation via pharmacological approaches inhibited inflammation and neointima formation in balloon injured rat carotid a...
Early Detection of Cardiovascular Autonomic Neuropathy Using Exercise Testing in Patients With Type 2 Diabetes Mellitus
Authors: Smriti Banthia
Journal: Circulation (2008)

Abstract 1132 Smriti Banthia, Jason Ng, Alexandru Chicos, Mark Molitch, Alan H Kadish, Jeffrey J Goldberger, Northwestern Univ, Chicago, IL Smriti Banthia, 2008 Finalist and Presenting Author
Indications for ACE inhibitors in the early treatment of acute myocardial infarction - Systematic overview of individual data from 100,000 patients in randomized trials
Authors: M G Franzosi, E Santoro, G Zuanetti, C Baigent, R Collins, M Flather, J Kjekshus, R Latini, L S Liu, A P Maggioni, P Sleight, K Swedberg, G Tognoni, S Yusuf, L Tavazzi, S Ball, L Kober, C Torp-Pedersen, E Braunwald, L Moye, M Pfeffer, L Santoro, J Pogue, Y Wang, Collaborat Aceimi.
Journal: Circulation (1998)
THE CULTIVATION OF THE TYPHOID BACILLUS FROM ROSE SPOTS.
Authors: Mark W Richardson
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 14790: Polypharmacy is a Predictor of Medication Non-adherence after Acute Coronary Syndrome: An Electronic Medication Monitoring Study
Authors: Siqin Ye, Nina Rieckmann, Ian M Kronish, Manjunath Harlapur, Matthew M Burg, Joseph E Schwartz, William F Chaplin, Karina W Davidson
Journal: Circulation (2010)

Objective: Non-adherence to prescribed medications is common in patients with cardiovascular disease. As cardiac regimens become increasingly complex, polypharmacy may play an important role in non...
Abstract 5890: Runx2 Inhibits TGF{beta}-induced Connective Tissue Growth Factor Gene Expression Through Physical Association With Smad3 in Vascular Smooth Muscle Cells
Authors: Yoshiaki Ohyama, Toru Tanaka, Takehisa Shimizu, Hiroko Sato, Norimichi Koitabashi, Hiroshi Doi, Tatsuya Iso, Masashi Arai, Masahiko Kurabayashi
Journal: Circulation (2009)

[Background]Balance between the synthesis and degradation of extracellular matrix (ECM) by vascular smooth muscle cells (VSMC) is a critical determinant of the plaque stability. We recently reporte...
Antisense to the Epstein-Barr Virus (EBV)-Encoded Latent Membrane Protein 1 (LMP-1) Suppresses LMP-1 and Bcl-2 Expression and Promotes Apoptosis in EBV-Immortalized B Cells
Authors: Jamie L. Kenney, Mary E. Guinness, Tyler Curiel, Jill Lacy
Journal: Blood (1998)
Abstract 16364: Improvement of Left Ventricular Ejection Fraction After Cardiac Resynchronization Therapy Can Be Predicted Based on Biventricular Capture on Electrocardiogram
Authors: Weeranun D Bode, Michael F Bode, Ross Simpson, Anil Gehi, Jennifer Schwartz, Paul Mounsey, Eugene Chung
Journal: Circulation (2013)

Background: CRT is associated with reduced morbidity and mortality. Predicting the approximately 30% of patients who will be non-responders to BiV pacing remains challenging. Ammann et al (Ann Inte...
General considerations regarding the in vitro and in vivo properties of block copolymer micelle products and their evaluation
Authors: Kumiko Sakai-Kato, Nobuhiro Nishiyama, Masato Kozaki, Takeshi Nakanishi, Yoshihiro Matsuda, Mai Hirano, Hiroyuki Hanada, Shigeru Hisada, Hiroshi Onodera, Hideyoshi Harashima, Yasuhiro Matsumura, Kazunori Kataoka, Yukihiro Goda, Haruhiro Okuda, Toru Kawanishi
Journal: Journal of Controlled Release (2015)
Association of PML-RARα Fusion mRNA Type With Pretreatment Hematologic Characteristics But Not Treatment Outcome in Acute Promyelocytic Leukemia: An Intergroup Molecular Study
Authors: Robert E. Gallagher, Cheryl L. Willman, James L. Slack, Janet W. Andersen, Yun Ping Li, David Viswanatha, Clara D. Bloomfield, Frederick R. Appelbaum, Charles A. Schiffer, Martin S. Tallman, Peter H. Wiernik
Journal: Blood (1997)
Abstract 16220: Baroreflex Failure Predisposes to Pulmonary Edema In Conscious Rats with Normal Left Ventricular Function
Authors: Kazuo Sakamoto, Kazuya Hosokawa, Tomoyuki Tobushi, Ken Onitsuka, Takeo Fujino, Keita Saku, Takamori Kakino, Masataka Ikeda, Tomomi Ide, Kenji Sunagawa
Journal: Circulation (2012)

Backgrounds: In heart failure with preserved ejection fraction (HFPEF), diastolic dysfunction was the central dogma. However, recent investigations have indicated that the complex mechanisms are in...
Abstract 4216: Non-invasive Prediction of Localization and Progression of Coronary Disease in Man Using Shear Stress Profiles Derived from 320-Row Detector Computed Tomography: Implications for Widespread Screening
Authors: Simone Melchionna, Frank J Rybicki, Dimitrios Mitsouras, Ahmet U Coskun, Sauro Succi, Massimo Bernaschi, Efthimios Kaxirias, Peter H Stone, Charles L Feldman
Journal: Circulation (2008)

Introduction: Low endothelial shear stress (ESS) is the local stimulus for the development and progression of atherosclerosis. In-vivo identification of areas of low ESS using coronary angiography ...
Issuing private prescriptions to non-exempt patients
Authors: N Maskrey, S Grant, P H Fitton
Journal: BMJ (1994)

Peptic ulceration has always been a clear contraindication to working on an offshore installation, and ready access to H2 antagonists over the counter would have two consequences: firstly, people would treat symptoms without a definitive diag- nosis being made, and, secondly, people would not take the drug properly even when the treatment was correct.These facts would increase the risks of employees continuing to work offshore with undiagnosed or masked peptic ulceration.The incidence ofmedical evacuations for gastrointestinal emergencies is not insignificant, and if the patient is in the remoter regions of the North Sea, for example, evacuation may result in considerable danger to the many people involved.
Tackling violence
Authors: J. P Shepherd
Journal: BMJ (1998)

Violence is now on the public health agenda in Britain largely because of increases in injury and homicide rates, particularly among men, and an increase in reports of domestic violence. In the absence of a national system of violence surveillance in accident and emergency departments, surveys such as the British Crime Survey are a starting point for understanding the circumstances and extent of assault, and one lesson that emerges is that health professionals need to do more to help prevent violence.

In 1995 the British Crime Survey data showed that the most common type of violence was that by acquaintances (40% of violent offences), followed by domestic violence (25%), violence by strangers (25%) and during robberies (10%) and that men were most at risk (6.7% of men; 3.8% of women).1 Importantly in a medical context, repeat victimisation is more common for violence than for other crimes: 30% of victims in the 1995 survey (and 43% in a 1989 …
Transplant Outcomes of 9/10 HLA Matched Unrelated Donors (MUD) Treated with Post-Transplant Cyclophosphamide for Prevention of Graft Versus Host Disease
Authors: Sai Ravi Pingali, Denai Milton, Uday R. Popat, Chitra M. Hosing, Qaiser Bashir, Amin M. Alousi, Roy Jones, Yago Nieto, Partow Kebriaei, Muzaffar H. Qazilbash, Borje S Andersson, Elizabeth J Shpall, Issa F. Khouri, Richard E. Champlin, Stefan O. Ciurea
Journal: Blood (2014)
Abstract 717: Spatial And Temporal Nonuniformity Of The Normal Left Ventricle During Isovolumic Contraction And Ejection By 2D Speckle Tracking Imaging
Authors: Anders Hodt, Marie Stugaard, Jonny Hisdal, Einar Stranden, Dan Atar, Kjetil Steine
Journal: Circulation (2008)

Background: The main purpose of this study was by novel 2D speckle tracking imaging (STI) to determine regional distribution of circumferential shortening, rotation and torsion (twist) and their relation to area ejection fraction (EF) during isovolumic contraction (IVC) and ejection phases in the normal left ventricle (LV). Methods: Twelve healthy subjects (22 ±3 years) were included. M-mode of atrio-ventricular level was used to describe LV longitudinal shortening, while circumferential strain, rotation and area EF were determined at four different LV short axis levels (basal, papillary, sub-papillary, apical) by STI. LV torsion was calculated as apical minus basal rotation. Results: See figure . During IVC, LV torsion demonstrated an “untwist pattern”, and LV shortened more in longitudinal than in circumferential direction. During ejection, the counter clockwise rotation increased from papillary level towards apex, −0.4 ± 3.3° and 9.6 ± 3.4° (p&lt;0.05), respectively, while circumferential shortening was larger in apex than papillary level, −25.4 ± 5.0 and −19.3 ± 2.4% (p&lt;0.05), respectively. EF increased from papillary level to apex, 52 ± 6.1 % and 65 ± 8.4 % (p&lt;0.05), respectively. Conclusion: This study has showed a regional nonuniform pattern of rotation and circumferential shortening, with corresponding changes in regional EF in normal LV through systole. The increased counter clockwise rotation and circumferential shortening towards apex during ejection may be of mechanistic importance for distribution of blood towards LV outflow tract. The greater extent of longitudinal- than circumferential shortening and untwisting suggest a LV spherical form during IVC.
CD44-Mediated Adhesiveness of Human Hematopoietic Progenitors to Hyaluronan Is Modulated by Cytokines
Authors: Stéphane Legras, Jean-Pierre Lévesque, Rachida Charrad, Kohji Morimoto, Caroline Le Bousse, Denis Clay, Claude Jasmin, Florence Smadja-Joffe
Journal: Blood (1997)
Rapid tranquillisation for agitated patients in emergency psychiatric rooms: a randomised trial of midazolam versus haloperidol plus promethazine
Journal: BMJ (2003)

Abstract Objective To compare two widely used drug treatments for people with aggression or agitation due to mental illness. Design Pragmatic, randomised clinical trial. Setting Three psychiatric emergency rooms in Rio de Janeiro, Brazil. Subjects 301 aggressive or agitated people. Interventions Open treatment with intramuscular midazolam or intramuscular haloperidol plus promethazine. Main outcome measures Patients tranquil or sedated at 20 minutes. Secondary outcomes: patients tranquil or asleep by 40, 60, and 120 minutes; restrained or given extra drugs within 2 hours; severe adverse events; another episode of agitation or aggression; needing extra visits from doctor during first 24 hours; overall antipsychotic load in first 24 hours; and not discharged by two weeks. Results 151 patients were randomised to midazolam, and 150 to haloperidol-promethazine mix. Follow up for the primary outcome was available for 298 (99%): 134/151 (89%) of patients given midazolam were tranquil or asleep after 20 minutes compared with 101/150 (67%) of those given haloperidol plus promethazine (relative risk 1.32 (95% confidence interval 1.16 to 1.49)). By 40 minutes, midazolam still had a statistically and clinically significant 13% relative advantage (1.13 (1.01 to 1.26)). After 1 hour, about 90% of both groups were tranquil or asleep. One important adverse event occurred in each group: a patient given midazolam had transient respiratory depression, and one given haloperidol-promethazine had a grande mal seizure. Conclusions Both treatments were effective. Midazolam was more rapidly sedating than haloperidol-promethazine, reducing the time people are exposed to aggression. Adverse effects and resources to deal with them should be considered in the choice of the treatment.
Abstract 4058: A longitudinal Study of Risk Factors for the Incident Abnormal Albuminuria in Diabetic American Indians: The Strong Heart Study
Authors: Jiaqiong (Susan) Xu, Elisa T Lee, Richard B Devereux, William C Knowler, Jeunliang Yeh, Jason G Umans, Momotaz Begum, Richard R Fabsitz, Barbara V Howard
Journal: Circulation (2006)

Objective: Using longitudinal analysis method to identify significant risk factors for incident abnormal albuminuria (urinary albumin/creatinine ratio [UACR] ≥ 30 mg/g) in diabetic American Indians...
Transcranial–facial Approach for Tumours of Superior Paranasal Sinuses and Orbit
Authors: Peter Clifford
Journal: Journal of the Royal Society of Medicine (1980)

A monobloc resection of the fronto-ethmoid sphenoid area may be performed through a combined cranial and facial approach. Osmotic cerebral dehydration increases the exposure of the anterior cranial fossa. The results of treatment in 26 patients (24 with malignant disease of the ethmoid area who had disease recurrence after previous radiotherapy with or without surgery) and the complications encountered are described. The clinical details of 9 of these patients have been included in an earlier report (Clifford 1977).
进行性肌无力-肌萎缩-肝功能损害
Authors: 陈艳, 沈敏
Journal: BMJ (2011)

患者男,37岁,因肌无力4个月于2011年3月收入本院.患者2010年11月初无明显诱因逐渐出现四肢无力,健身时需减少杠铃重量,上楼梯费力,伴四肢酸胀,无发热、皮疹、关节痛.患者中年男性,隐匿起病,慢性病程,主要表现为四肢近端对称性肌无力.肌无力常见的原因可以分为肌源性损害、神经-肌接头肌病、神经源性损害和其他全身性或先天性疾病。
Erythropoietin Receptor Mutations Associated With Familial Erythrocytosis Cause Hypersensitivity to Erythropoietin in the Heterozygous State
Authors: Stephanie S. Watowich, Xiaoling Xie, Ursula Klingmuller, Juha Kere, Mikael Lindlof, Stig Berglund, Albert de la Chapelle
Journal: Blood (1999)