tbuckley/cabot-search huggingface dataset:
Oral hymecromone decreases hyaluronan in human study participants
Authors: Joelle I. Rosser, Nadine Nagy, Riya Goel, Gernot Kaber, Sally Demirdjian, Jamie Saxena, Jennifer B. Bollyky, Adam R. Frymoyer, Ana E. Pacheco-Navarro, Elizabeth B. Burgener, Jayakumar Rajadas, Zhe Wang, Olga Arbach, Colleen E. Dunn, Anissa Kalinowski, Carlos E. Milla, Paul L. Bollyky
Journal: Journal of Clinical Investigation (2022)

BACKGROUNDHyaluronan (HA), an extracellular matrix glycosaminoglycan, has been implicated in the pathophysiology of COVID-19 infection, pulmonary hypertension, pulmonary fibrosis, and other diseases, but is not targeted by any approved drugs. We asked whether hymecromone (4-methylumbelliferone [4-MU]), an oral drug approved in Europe for biliary spasm treatment that also inhibits HA in vitro and in animal models, could be repurposed as an inhibitor of HA synthesis in humans.METHODSWe conducted an open-label, single-center, dose-response study of hymecromone in healthy adults. Subjects received hymecromone at 1200 (n = 8), 2400 (n = 9), or 3600 (n = 9) mg/d divided into 3 doses daily, administered orally for 4 days. We assessed safety and tolerability of hymecromone and analyzed HA, 4-MU, and 4-methylumbelliferyl glucuronide (4-MUG; the main metabolite of 4-MU) concentrations in sputum and serum.RESULTSHymecromone was well tolerated up to doses of 3600 mg/d. Both sputum and serum drug concentrations increased in a dose-dependent manner, indicating that higher doses lead to greater exposures. Across all dose arms combined, we observed a significant decrease in sputum HA from baseline after 4 days of treatment. We also observed a decrease in serum HA. Additionally, higher baseline sputum HA levels were associated with a greater decrease in sputum HA.CONCLUSIONAfter 4 days of exposure to oral hymecromone, healthy human subjects experienced a significant reduction in sputum HA levels, indicating this oral therapy may have potential in pulmonary diseases where HA is implicated in pathogenesis.TRIAL REGISTRATIONClinicalTrials.gov NCT02780752.FUNDINGStanford Medicine Catalyst, Stanford SPARK, Stanford Innovative Medicines Accelerator program, NIH training grants 5T32AI052073-14 and T32HL129970.
DIRECT ANORECTAL INTUBATION DURING COLONOSCOPY – A LOGICAL NEW PARADIGM
Authors: K. Mönkemüller, K. Manovski, A. Martínez-Alcalá
Journal: Endoscopy (2022)

Traditionally, endoscopists are trained to introduce the colonoscope blindly through the anus into the rectum and then start the procedure. This practice originated during the era of fiberoptic endoscopy but has remained standard despite availability of wide-angle viewing video colonoscopy techniques, which practically allow for a better inspection of this area. Indeed, esophagogastroduodenoscopy was also inserted blindly until last century, but now it is standard to insert under direct vision. This video demonstrates on the feasibility, practicality and potential advantages of performing direct intubation and visualization of the anorectum with the colonoscope, which we have practiced since 2001.
SPYGLASS-CHOLANGIOSCOPY: ARE THE DAYS OF THE “BARIUM ENEMA OF THE BILIARY TREE” (ERCP) NUMBERED?
Authors: A. Vyas, W.-R. Matull
Journal: Endoscopy (2022)

Aims Direct Cholangioscopy is a relatively new intervention that has been limited to use in Specialist centres. It has proved helpful for endoscopic management of gallstones and bile duct strictures. We present our experience of introducing SpyGlass-Cholangioscopy to our District General Hospital (DGH). We aim to assess applicability, feasibility and safety of SpyGlass-Cholangioscopy in a DGH setting in England, including a cost analysis compared with surgical bile duct exploration (an alternative for gallstones).
Acute Decompensated Heart Failure in the Setting of Acute Coronary Syndrome
Authors: Josephine Harrington, W. Schuyler Jones, Jacob A. Udell, Karen Hannan, Deepak L. Bhatt, Stefan D. Anker, Mark C. Petrie, Ola Vedin, Javed Butler, Adrian F. Hernandez
Journal: JACC Heart Failure (2022)
EXPERIENCE WITH THE USE OF SINGLE-USE EXALT D DUODENOSCOPE IN DAILY PRACTICE IN A TERTIARY HOSPITAL
Authors: L. Guilabert, B. Martínez-Moreno, R. Muñoz, F. Ruiz, L. Compañy, J. Martínez, C. Mangas-Sanjuán, J.R. Aparicio
Journal: Endoscopy (2022)

Aims Endogenous multidrug-resistant (MDR) infections are associated with the use of contaminated duodenoscopes. Disposable duodenoscopes can prevent them. Our aim is to evaluate the functionality of the EXALT D single-use duodenoscope in daily practice.
ENDOSCOPIC SUBMUCOSAL DISSECTION FOR THE TREATMENT OF GIANT COLORECTAL LESIONS. OUTCOMES FROM A PROSPECTIVE MULTICENTER REGISTRY
Authors: J. Santiago Garcia, D. De Frutos Rosa, E. Rodriguez De Santiago, P. De Maria Pallares, E. Albeniz Arbizu, J.C. Marin Gabriel, B. Peñas Garcia, A. Burgos Garcia, A. Herreros de Tejada Echanojauregui
Journal: Endoscopy (2022)

Aims To evaluate the outcomes of endoscopic submucosal dissection (ESD) for the treatment of giant (≥10cm) colorectal lesions (CRL).
Targeting TLR4 during vaccination boosts MAdCAM-1 <sup>+</sup> lymphoid stromal cell activation and promotes the aged germinal center response
Authors: Alice E. Denton, James Dooley, Isabella Cinti, Alyssa Silva-Cayetano, Sigrid Fra-Bido, Silvia Innocentin, Danika L. Hill, Edward J. Carr, Andrew N.J. McKenzie, Adrian Liston, Michelle A. Linterman
Journal: Science Immunology (2022)

The failure to generate enduring humoral immunity after vaccination is a hallmark of advancing age. This can be attributed to a reduction in the germinal center (GC) response, which generates long-lived antibody-secreting cells that protect against (re)infection. Despite intensive investigation, the primary cellular defect underlying impaired GCs in aging has not been identified. Here, we used heterochronic parabiosis to demonstrate that GC formation was dictated by the age of the lymph node (LN) microenvironment rather than the age of the immune cells. Lymphoid stromal cells are a key determinant of the LN microenvironment and are also an essential component underpinning GC structure and function. Using mouse models, we demonstrated that mucosal adressin cell adhesion molecule-1 (MAdCAM-1)-expressing lymphoid stromal cells were among the first cells to respond to NP-KLH + Alum immunization, proliferating and up-regulating cell surface proteins such as podoplanin and cell adhesion molecules. This response was essentially abrogated in aged mice. By targeting TLR4 using adjuvants, we improved the MAdCAM-1
EFFECTIVE SINGLE-SESSION GREEN LASER HEMOSTASIS OF REFRACTORY BLEEDING FROM GASTRIC ADENOCARCINOMA
Authors: D. Luna-Rodriguez, B. Burgueno-Gomez, J. Garcia-Alonso, C. Chavarria-Herbozo, R. Sanchez-Ocana, C. de la Serna, M. Perez-Miranda, R. Busta-Nistal
Journal: Endoscopy (2022)

Radiotherapy is used to control bleeding from gastric malignancy, but it’s inconvenient for frail patients. Neodymium-YAG(“green”) lasers are widely available in Urology. An 89-yo woman with unresectable gastric adenocarcinoma experienced bleeding requiring frequent blood transfusions. Gastroscopy showed large antral ulceration with exposed vessels. Sclerotherapy failed to control bleeding. Patient performance status was otherwise good. A transpyloric duodenal SEMS was placed to treat impending outlet obstruction and a green laser probe was used to ablate visible vessels/bleeding spots within large ulcerated area. The patient did not experience any subsequent bleeding throughout the 5-months she survived on palliative care.
EVALUATING OF CHANGES IN COLONOSCOPY QUALITY INDICATORS SUBSEQUENT TO BOWEL PREPARATION ADEQUACY
Authors: H. Hula, A. Stupnytskyy, M. Artyushenko, V. Vokh, N. Kovalyshyn, A. Patiy, O. Kocherkevych, I. Kozyak
Journal: Endoscopy (2022)

Aims Insufficient bowel preparation (BP) is known to cause a decrease in polyp detection rate (PDR) and adenoma detection rate (ADR). This study aimed to evaluate a statistically significant relationship between BP, rated on the Boston Bowel Preparation Scale (BBPS), with the ADR and the PDR. Primary endpoint was the ADR depending on BP adequacy.
COMPARISON OF DYE-SPRAYING CHROMOENDOSCOPY AND VIRTUAL CHROMOENDOSCOPY FOR COLONIC DYSPLASIA DETECTION IN LONGSTANDING INFLAMMATORY BOWEL DISEASE
Authors: J. Correia, A. Ponte, L. Proença, A. Rodrigues, R. Pinho, S. Leite, C. Fernandes, J. Rodrigues, J.C. Silva, C. Gomes, E. Afecto, M. Estevinho, T. Freitas
Journal: Endoscopy (2022)

Aims This study aimed to compare virtual chromoendoscopy (VCE) and dye-spraying chromoendoscopy (DCE) for colonic surveillance in patients with long-standing extensive Inflammatory Bowel Disease (IBD).
SINGLE-OPERATOR PERORAL CHOLANGIOSCOPY FOR THE TREATMENT OF COMPLEX BILIARY AND PANCREATIC STONES: A SYSTEMATIC REVIEW AND META-ANALYSIS OF 20 YEARS OF EVIDENCE
Authors: A. Al-Lehibi, A. Al Balkhi, A. Alsuleimani, A. Sultan, A. Bashmail, M. AlBalkhi, S. Basalama, A. Almtawa, A. AlEid, A. Alqutub, A. Alamr, A. AlGhamdi, A. AlGhamdi, B. AlIbrahim, M. Al Ahmari, S. AlRajhi, S. Ahmad, N. Alotaibi
Journal: Endoscopy (2022)

Aims The efficacy of peroral cholangioscopy (POC) in the treatment of complex biliary and pancreatic stones has been investigated in numerous studies. This review aims to pool the evidence on the performance of POC in difficult pancreatic/biliary stones, and the overall incidence of adverse events.
Using big data and mobile health to manage diarrhoeal disease in children in low-income and middle-income countries: societal barriers and ethical implications
Authors: Karen H Keddy, Senjuti Saha, Samuel Kariuki, John Bosco Kalule, Farah Naz Qamar, Zoya Haq, Iruka N Okeke
Journal: The Lancet Infectious Diseases (2021)
EFFECTIVENESS AND SAFETY OF TRANSPANCREATIC PAPILLOTOMY: A LARGE SCALE RETROSPECTIVE CROSS-SECTIONAL STUDY
Authors: A. Papaefthymiou, T. Florou, A. Koffas, C. Kateri, K. Pateras, F. Fytsilis, D. Chougias, T. Bektsis, A. Manolakis, A. Kapsoritakis, S. Potamianos
Journal: Endoscopy (2022)

Aims Difficult cannulation represents a common condition during endoscopic retrograde cholangiopancreatography (ERCP). This study assessed the efficacy and adverse events during transpancreatic sphincterotomy (TPS), and investigated confounders associated with those outcomes.
THE ROLE OF ANTIBIOTICS IN ENDOSCOPIC TRANSMURAL DRAINAGE OF POST-INFLAMMATORY PANCREATIC AND PERIPANCREATIC FLUID COLLECTIONS
Authors: M. Jagielski, W. Kupczyk, J. Piątkowski, M. Jackowski
Journal: Endoscopy (2022)

Aims Assessment of the role of antibiotics in endoscopic transmural drainage of post-inflammatory pancreatic and peripancreatic fluid collections (PPPFCs).
MID GUT EXPLORATION: CAN CAPSULE ENDOSCOPY ALWAYS DETERMINE THE INSERTION ROUTE OF DEVICE-ASSISTED ENTEROSCOPY?
Authors: M. Fernandez, Y Viesca, L. Verset, L. Rocq, P. Demetter, M. Arvanitakis
Journal: Endoscopy (2022)

Small bowel capsule endoscopy (SBCE) is a well-known non-invasive technique that has revolutionized the exploration of the midgut as device-assisted enteroscopy (DAE) development. Both procedures are complementary and SBCE can be considered a previous guide before a deep enteroscopy procedure that requires expertise, time and general anesthesia. Which route of insertion (anterograde or retrograde) should be chosen, isn’t simple. Few studies have tried to identify a time index based on SBCE landmarks to help the decision of the route insertion. We illustrated two video cases where those formulas could not determine the correct approach before motorized spiral enteroscopy.
73P Effect of diarrheal prophylaxis or dose escalation on neratinib-associated diarrhea and tolerability in patients with HER2+ early-stage breast cancer: Final findings from the CONTROL trial
Authors: A. Chan, M. Ruiz Borrego, G. Marx, A. Brufsky, A.J. Chien, M.P. Thirlwell, M.E. Trudeau, R. Bose, J.Á. García Saenz, D. Egle, B. Pistilli, J. Wassermann, K.A. Cheong, D. Semsek, C.F. Singer, D. Diprimeo, N. Foruzan, L.M. McCulloch, C.H. Barcenas
Journal: Annals of Oncology (2022)
63P Efficacy and safety results by menopausal status in monarchE: Adjuvant abemaciclib combined with endocrine therapy in patients with HR+, HER2- high-risk early breast cancer
Authors: S. Paluch-Shimon, P. Neven, J. Huober, I. Cicin, Z. Jiang, M.P. Goetz, C. Shimizu, C. Huang, R.J. Wei, S.C. Nabinger, T. Forrester, N. Harbeck
Journal: Annals of Oncology (2022)
CLINICAL AND ENDOSCOPIC FINDINGS IN GASTROINTESTINAL AMYLOIDOSIS: A RETROSPECTIVE SINGLE-CENTER STUDY
Authors: E. Dias, J. Santos-Antunes, M. Marques, F. Vilas-Boas, R. Morais, A.L. Santos, J. Lopes, F. Carneiro, G. Macedo
Journal: Endoscopy (2022)

Aims To describe the main clinical and endoscopic characteristics of gastrointestinal amyloidosis and evaluate its prognostic impact.
THE ROLE OF ENDOSCOPIC SUBMUCOSAL DISSECTION IN THE MANAGEMENT OF GASTRIC INFLAMMATORY FIBROID POLYPS: A SINGLE-CENTER EXPERIENCE
Authors: E. Dias, M. Marques, J. Santos-Antunes, F. Baldaque-Silva, P. Moutinho-Ribeiro, G. Macedo
Journal: Endoscopy (2022)

Aims To evaluate safety and effectiveness of endoscopic submucosal dissection in the management of gastric inflammatory fibroid polyps not amenable to resection with snare polypectomy.
AUTOMATIC IDENTIFICATION OF GASTROSCOPY SURVEILLANCE INTERVAL AND FOLLOW-UP REMINDER FOR HIGH-RISK PATIENTS UNDERGOING SCREENING UPPER ENDOSCOPY
Authors: L. Wu, J. Li, C. Shi, Z. Dong, S. Hu, X. Hu, H. Yu
Journal: Endoscopy (2022)

Aims Gastric adenocarcinoma develops through a cascade of precancerous lesions. Determining surveillance intervals and timely reminding patients with precancerous lesions is critical but time-consuming. We aimed to create a system that automatically categorizes patients into different surveillance intervals and sends patients timely follow-up messages.
Colorectal Cancer Incidence Among Adults Younger Than 50 Years—Understanding Findings From Observational Studies of Lower Gastrointestinal Endoscopy
Authors: Gregory S. Calip, Neal J. Meropol, David S. Weinberg
Journal: JAMA Oncology (2022)

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Immunocompromise and durability of BNT162b2 vaccine against severe outcomes due to omicron and delta variants
Authors: Sara Y Tartof, Jeff M Slezak, Laura Puzniak, Vennis Hong, Fagen Xie, Bradley K Ackerson, Srinivas R Valluri, Luis Jodar, John M McLaughlin
Journal: The Lancet Respiratory Medicine (2022)
ENDOSCOPIC BILIARY DRAINAGE IN THE PALLIATIVE TREATMENT OF KLATSKIN TUMOURS: OUTCOMES AND FACTORS ASSOCIATED WITH SUCCESS OR FAILURE
Authors: S. Rokhsi, T. Addajou, S. Mrabti, A. Benhamdane, A. Sair, A. Touibi, R. Berrida, I. El koti, F. Rouibaa, A. Benkirane, H. Seddik
Journal: Endoscopy (2022)

Aims The aim is to report the results of endoscopic biliary drainage as well as the factors associated with its success or failure.
INTRACHOLEDOCAL BLEEDING DUE TO EPICHOLEDOCAL ARTERY LACERATION AFTER ENDOSCOPIC BALLOON DILATATION
Authors: E. Pijoan Comas, N. Torres Monclús, D.C. Bayas Pástor, M. Alburquerque Miranda, G. Torres Vicente, A. Vargas García, I. Miguel Salas, P. Huelin Álvarez, M. Figa Francesch, F. Gonzalez-Huix Lladó
Journal: Endoscopy (2022)

A 58-year-old man underwent ERCP for symptomatic choledocholithiasis. Dilatated CBD(15mm) with narrowing of intrapancreatic CBD(7mm) and 12mm lithiasis in medium CBD were found. Lithiasis could not be removed with balloon. Endoscopic-balloon-dilatation up to 14mm was performed. Immediately following balloon deflation, a spurting pulsatile bleeding from CBD was seen, probably due to epicholedocal artery laceration. Bleeding could not be controlled by compression. However, adrenalin injection achieved temporary haemostatic control. Lithiasis was removed. cSEMS of 4cm was placed. The bleeding was controlled during ERCP, the patient was discharged in 24h and stent had spontaneously migrated at 4 weeks.
INCLUSION OF ADVANCED SERRATED POLYPS INCREASES THE YIELD OF COLORECTAL CANCER SCREENING BASED ON FECAL IMMUNOCHEMICAL TESTING
Authors: D. Van Toledo, E. Breekveldt, J. Ijspeert, L. De Jonge, H. Van De Schootbrugge-Vandermeer, A. Van Vuuren, F. Van Kemenade, C. Ramakers, I. Nagtegaal, M. Van Leerdam, M. Spaander, I. Lansdorp-Vogelaar, E. Toes-Zoutendijk, E. Dekker
Journal: Endoscopy (2022)

Aims Although advanced serrated polyps (ASPs) have a comparable risk as advanced adenomas (AA) to develop into colorectal cancer (CRC), the yield of most screening programs is based only on AA and CRC. Therefore, we assessed the ASP detection rate within the Dutch screening program and evaluated the yield of screening including ASPs.
Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer
Authors: Huocong Huang, Zhaoning Wang, Yuqing Zhang, Rachana N. Pradhan, Debolina Ganguly, Raghav Chandra, Gilbert Murimwa, Steven Wright, Xiaowu Gu, Ravikanth Maddipati, Sören Müller, Shannon J. Turley, Rolf A. Brekken
Journal: Cancer Cell (2022)

Recent studies have identified a unique cancer-associated fibroblast (CAF) population termed antigen-presenting CAFs (apCAFs), characterized by the expression of major histocompatibility complex class II molecules, suggesting a function in regulating tumor immunity. Here, by integrating multiple single-cell RNA-sequencing studies and performing robust lineage-tracing assays, we find that apCAFs are derived from mesothelial cells. During pancreatic cancer progression, mesothelial cells form apCAFs by downregulating mesothelial features and gaining fibroblastic features, a process induced by interleukin-1 and transforming growth factor β. apCAFs directly ligate and induce naive CD4+ T cells into regulatory T cells (Tregs) in an antigen-specific manner. Moreover, treatment with an antibody targeting the mesothelial cell marker mesothelin can effectively inhibit mesothelial cell to apCAF transition and Treg formation induced by apCAFs. Taken together, our study elucidates how mesothelial cells may contribute to immune evasion in pancreatic cancer and provides insight on strategies to enhance cancer immune therapy.
CAP-SUCTION UNDERWATER ENDOSCOPIC MUCOSAL RESECTION (CAP-UEMR) AS AN EASY-TO-USE AND EFFICIENT TECHNIQUE FOR TREATING FLAT COMPLEX COLORECTAL LESIONS: A PROOF OF CONCEPT PILOT STUDY
Authors: H. Uchima, A. Calm, I. Marín, J. Colán-Hernández, N. Caballero, I. Iborra, M. Puig, M. Fortuny, A. Ortega, R. Turro, M. Da Costa, R. Temiño, M. Rosinach, A. Mata, E. Domenech, V. Moreno, J. Espinos, M. Pellisé
Journal: Endoscopy (2022)

Aims To evaluate the safety, utility and technical success of Cap-suction underwater EMR (CAP-UEMR) for the treatment of complex colorectal lesions.
SHOULD WE RECOMMEND THE PERFORMANCE OF ROUTINE COLONOSCOPIES AFTER ANY EPISODE OF ACUTE DIVERTICULITIS?
Authors: A. Ojeda Gómez, M.D. Pico Sala, J. Barragán Martínez, A. García Soria, J. Sáez Fuster, A.M. Iñigo Chaves, A. Brotons Brotons, M.F. García, J. Sola-Vera Sánchez
Journal: Endoscopy (2022)

Aims The incidence of acute diverticulitis (AD) is rising because of the progressive ageing of the population. Follow-up colonoscopies are usually performed to exclude concomitant colorrectal cancer (CRC). However, recent publications indicate that their real benefit may not compensate for their potential risks. Our aim was to assess if performing colonoscopies to all patients suffering from an AD would improve the CRC detection.
ENDOSCOPIC ULTRASOUND-GUIDED FINE NEEDLE BIOPSY IN PATIENTS WITH SUSPECTED GASTRIC LINITIS PLASTICA
Authors: A. Assaf, B. Terris, L.J. Palmieri, A. Rouquette, F. Beuvon, A. Pellat, E. Abou Ali, C. Ginestet, A. Belle, R. Hallit, A. Dohan, S. Chaussade, R. Coriat, M. Barret
Journal: Endoscopy (2022)

Aims Gastric linitis plastica (GLP) is a diffuse infiltrating type of gastric adenocarcinoma. It is associated with a poor prognosis and a five-year survival of 3-10%. The infiltrating profile of this tumor explains the low yield of the superficial mucosal biospies. The objective of this study was to investigate the role of endoscopic ultrasound-fine needle biopsy (EUS-FNB) in the diagnosis of GLP.
CIRCUMFERENTIAL ENDOSCOPIC SUBMUCOSAL DISSECTION FOR REFRACTORY DYSPLASTIC BARRETT’S ESOPHAGUS AFTER MUCOSAL RESECTIONS AND RADIOFREQUENCY ABLATION – A SALVAGE AND DEFINITIVE TREATMENT APPROACH?
Authors: C. O'Neill, P. Barreiro, R. Mendo, A. Mascarenhas, A.R. Franco, C. Félix, D. Pinto, J. Castela, C. Chagas
Journal: Endoscopy (2022)

77-year-old woman with C5M6 Barrett’s esophagus(BE) and progressive high grade dysplasia (HGD) visible lesions despite sequential endoscopic mucosal resection procedures and radiofrequency ablation of the remaining BE. The patient was referred to our department for endoscopic submucosal dissection (ESD). Regardless of extensive scaring and submucosal fibrosis from previous procedures, en-bloc circumferential excision of a 6cm-length segment encompassing all the dysplastic lesions was successfully achieved. Histological showed extensive HGD, completely resected.
Discontinuation, suboptimal adherence, and reinitiation of oral HIV pre-exposure prophylaxis: a global systematic review and meta-analysis
Authors: Jing Zhang, Chunyan Li, Junjie Xu, Zhili Hu, Sarah E Rutstein, Joseph D Tucker, Jason J Ong, Yongjun Jiang, Wenqing Geng, Sarah T Wright, Myron S Cohen, Hong Shang, Weiming Tang
Journal: The Lancet HIV (2022)
MULTI-METHOD VALIDATION OF AN ARTIFICIAL INTELLIGENCE-BASED BOWEL PREPARATION QUANTITATIVE SYSTEM
Authors: L. Yao, H. Wu, R. Gong, L. Zhang, H. Yu
Journal: Endoscopy (2022)

Aims The effectiveness of colonoscopy is dependent on the cleanliness of the bowel. Mandating the standardization of bowel preparation assessment and objectively identifying inadequate bowel preparation is important to improve colonoscopy patients outcome. With the development of artificial intelligence (AI) technology, automatic bowel preparation assessment systems have been developed. Despite the diversity of algorithms and scoring logics, systematic exploration and verification of the optimal algorithm and scoring logic are still lacking. In this study, we compared the performance among current mainstream models and video output strategies using 816 prospectively enrolled colonoscopy procedures. The aim of this study is to develop an optimum bowel preparation assessment system and improve the standardization of AI-based bowel preparation assessment.