tbuckley/cabot-search huggingface dataset:
Abstract 16066: Genomic Autopsy of 103 Sudden Deaths in the Young Reveals the Importance of Cardiomyopathy Genes and Non-Mendelian Risk
Authors: Gregory Webster, Megan Puckelwartz, Lorenzo Pesce, Dellefave-Castillo Lisa, Carlos Vanoye, Patrick Page, Samuel D Kearns, Tess Pottinger, Steven M White, Ponni Arunkumar, Rachael Olson, Amber Kofman, Nora Ibrahim, Alexander Ing, Casey Brew, Kai Lee Yap, Sabah Kadri, Alfred L George, Elizabeth M McNally
Journal: Circulation (2020)

Introduction: Genetic testing after sudden death in the young can identify pathogenic cardiac gene variants. Hypothesis: Genomic methods, coupled with phenotype evaluation, reveal non-Mendalian risks. Methods: We conducted clinical analysis and whole genome sequencing on 103 decedents aged 1-40 (mean age at death 23.7 years) accrued prospectively from 2015 to 2019 across 22 states. Postmortem pathological findings were classified as: known cardiac disorders, findings of uncertain significance (FUS), or sudden unexplained death (SUD, indicating no postmortem pathological diagnosis). Parental DNA and clinical data were obtained where possible. Variants were classified by an independent clinical genetic laboratory. Results: Among the 103 decedents, 34 had a postmortem clinical diagnosis, 23 had FUS, and 46 were classified as SUD. Pathogenic/likely pathogenic (P/LP) variants in arrhythmia or cardiomyopathy genes were identified in 17 (16.5%) decedents. The distribution of P/LP variants was not associated with age at death (OR 1.01 [0.97, 1.05], p=0.54); however, a multivariable analysis including decedent phenotype, ancestry and sex demonstrated that younger decedents had a higher burden of curated P/LP/VUS variants (effect size -1.5, p=0.0019). DNA from 31 parent-decedent trios and 14 parent-decedent dyads revealed 9 transmitted P/LP variants and 1 de novo P/LP variant. More than half of parents transmitting a P/LP variant (5/9) did not have clinical findings associated with the genotype. Conclusions: Whole genome sequencing effectively revealed P/LP variants in cases of sudden death in the young, implicating both arrhythmia and cardiomyopathy genes. In addition, both genotype and phenotype analyses suggest additional non-Mendelian risk mechanisms.
Design of a Portable Pulse Oximeter
Authors: Macian Canto Estefanía
Journal: Clinical Cardiology and Cardiovascular Interventions (2021)

Oximetry is a technique that allows the evaluation of oxygen levels in the blood in patients who suffer from a pulmonary disorder or present a respiratory pathology. The main objective of this research is the design of a portable pulse oximeter, which corrects the problems of the oximeter previously developed by the ICID, due to the module used at defined low perfusion levels (modulation index of 0.4% and lower), It had difficulties to synchronize with the patient's pulses and for severe low perfusion conditions (signals with a modulation index of 0.2% and less), the module did not operate. With respect to past designs, this project incorporates an oximetry module produced by recognized companies in this field, thus eradicating the deficiencies of the previous models. The components were updated, using, for example, an LCD screen, a DC / DC converter, optocouplers and the MSP430F2618 microcontroller which is very suitable for this design, as it contains sufficient resources in data and program memory. The design of the schematics of each circuit that makes up the oximeter is carried out. As well as the development of firmware programming, based on the graphic design of the algorithms of the main functions of the equipment.
Abstract 13170: Mechanisms of Slow/No-Reflow Phenomenon During Percutaneous Coronary Intervention: An Intravascular Ultrasound Study
Authors: Yasuhisa Nakao, Shinji Inaba, Takumi Sumimoto, Shuntaro Ikeda, Makoto Saito, Osamu Yamaguchi
Journal: Circulation (2019)

Introduction: Slow/no-reflow phenomenon is a critical complication during PCI that leads to poor outcomes. Distal embolization is a known major contributing factor of slow/no-reflow phenomenon. Fur...
Abstract 13409: Impact of Smoking on Vascular Endothelial Growth Factor D and Mortality in Patients With Suspected or Known Coronary Artery Disease: The ANOX Study
Authors: Hiromichi Wada, masahiro suzuki, Morihiro Matsuda, Yoichi Ajiro, Tsuyoshi Shinozaki, Satoru Sakagami, Kazuya Yonezawa, masatoshi shimizu, JUNICHI FUNADA, Takashi Takenaka, Yukiko Morita, Toshihiro Nakamura, Kazuteru Fujimoto, Hiromi Matsubara, Toru Kato, Takashi Unoki, Daisuke Takagi, Kyohma Wada, Miyaka Wada, Moritake Iguchi, Nobutoyo Masunaga, MITSURU ISHII, Kazuhiko Kotani, Mitsuru Abe, Masaharu Akao, Koji Hasegawa
Journal: Circulation (2020)

Background: Smoking is a risk factor for mortality in the general population and in patients with coronary artery disease (CAD). Vascular endothelial growth factor D (VEGF-D) is a secreted glycoprotein that can act as lymphangiogenic and angiogenic growth factors. Recently, we demonstrated that circulating VEGF-D levels are associated with the risk of mortality in patients with suspected or known CAD. However, whether VEGF-D levels differ according to smoking status and whether smoking modifies the relationship between VEGF-D and mortality in those patients are unknown. Methods: Using data from a multicenter, prospective cohort of 2418 patients with suspected or known CAD, we assessed the association between smoking status and VEGF-D and the impact of smoking status on the association between VEGF-D levels and the risk of all-cause death. VEGF-D was measured in 955 never smokers, 1035 former smokers, and 428 current smokers enrolled in the ANOX Study. Patients were followed up over 3 years. Results: The mean age (standard deviation [SD]) of the patients was 70.6 (10.4) years; 67.2% were men. Current smokers exhibited significantly higher levels of VEGF-D compared to former smokers and never smokers (median [interquartile range], 343 [214-556], 312 [201-500], 291 [182-485] pg/mL, respectively; P =0.006). Stepwise multiple linear regression analysis revealed that the log-transformed VEGF-D level was independently associated with current smoking ( P =0.002), but not with former smoking. After adjusting for potential clinical confounders, the VEGF-D level was significantly associated with all-cause death in never smokers (hazard ratio per 1-SD increase [HR], 1.31; 95% confidence interval [CI], 1.10-1.55) and in former smokers (HR, 1.22; 95% CI, 1.08-1.37), but not in current smokers (HR, 0.92; 95% CI, 0.65-1.22). Furthermore, VEGF-D provided incremental prognostic information to the model with potential clinical confounders and the established cardiovascular biomarkers in never smokers, but not in former smokers or in current smokers. Conclusions: Current smoking was independently associated with higher levels of VEGF-D. The prognostic value of VEGF-D on mortality was most pronounced in never smokers among patients with suspected or known CAD.
Abstract 16177: Race and Sex-specific Long-term Risk of Incident Heart Failure in Adults Stratified by Fasting Glucose Level: Lifetime Risk Pooling Project
Authors: Arjun Sinha, Hongyan Ning, Faraz S Ahmad, Michael Bancks, Mercedes R Carnethon, Norrina B Allen, John T Wilkins, Donald M Lloyd-jones, Sadiya S Khan
Journal: Circulation (2020)

Introduction: While the association of diabetes with heart failure (HF) is well-established, the long-term risk (LR) of incident HF with prediabetes across the life course is not known. Furthermore, race-sex disparities in LR of HF across categories of fasting plasma glucose (FPG) has not been described. To inform HF preventive strategies, we compared the race- and sex-specific LR of HF across categories of FPG in adults. Methods: Individual-level data from adults free of baseline HF was pooled from 6 population-based cohorts stratified by baseline age (40-59, 60-79 years) and race-sex groups. We defined FPG status as normal (&lt;100 mg/dL), prediabetes (FPG 100-125 mg/dL) and diabetes (FPG ≥126 mg/dL or use of antihyperglycemic agents). Modified Kaplan-Meier analysis was performed by FPG strata to estimate the LR of HF (30-year in middle-aged and 20-year in older adults) adjusted for the competing risk of non-HF death. We estimated adjusted hazard ratios (aHR) for HF in each FPG strata using Cox proportional regression models. Results: Of the 40,117 participants, 24% were black and 56% were women. During 638,910 person-years of follow-up, there were 4,846 cases of incident HF. In middle-aged adults, the LR of HF was significantly higher among individuals with prediabetes (6.1 [4.8, 7.4] to 14.4 [9.6, 19.2]%) compared with normal FPG (3.5 [3.0, 4.1] to 11.7 [9.1, 14.3]%). In older adults with prediabetes compared with normal FPG, LR of HF was significantly higher in white men (13.5 [12.0, 14.9]% vs 10.4 [9.2, 11.6]%) and women (12.2 [10.8, 13.6]% vs 7.8 [6.9, 8.7]%) but not in black men (12.2 [9.0, 15.3]% vs 14.6 [11.6, 17.6]%) or women (13.5 [10.1, 16.8]% vs 11.7 [9.4, 14.0]%). Race-sex specific aHR for HF across FPG strata are shown in the table. Conclusions: Compared with normal FPG, prediabetes was associated with significantly greater LR of HF in middle-aged but not in older adults. Of all groups, black women with diabetes qualitatively had a disproportionately higher LR of HF.
Disclosure of Presidential Health Information—Reply
Authors: Robert Klitzman
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Corrigendum to “Sensitivity to antitubulin chemotherapeutics is potentiated by a photoactivable nanoliposome” [Biomaterials 141 (2017) 50–62]
Authors: Xiaobing Wang, Xiufang Liu, Yixiang Li, Pan Wang, Xiaolan Feng, Quanhong Liu, Fei Yan, Hairong Zheng
Journal: Biomaterials (2021)
Abstract 17418: Religious Attendance and Ideal Cardiovascular Health in Older Women
Authors: Jonathan Z Butler, Natalie B Slopen, Alan Zaslavsky, Julie E Buring, Michelle A Albert
Journal: Circulation (2020)

Introduction: Although religious attendance can act as a protective health factor likely through social support and inherent beliefs, little is known about the relationship between the frequency of religious attendance and ideal cardiovascular health (ICH), particularly in older women, many of whom attend religious activities. Methods: We utilized the Women’s Health Study (WHS) follow-up psychosocial stress cohort (n=24360; mean age=71.8, SD= 5.8 years) to evaluate the cross-sectional relationship between current religious service attendance and ICH, as defined by the American Heart Association 2020 ICH score. Frequency of religious attendance was classified as never, at least once a year, at least once a month, and at least once a week. Results: Compared to women who never attend religious services, women who participate in religious services at least once a week are more likely to be hypertensive and hypercholesterolemic, less likely to be smokers or to use alcohol, less physically active, had lower education levels and more likely to earn &lt; $50,000 annually/household. In age-adjusted models, religious service attendance at least once a month and once a week was associated with a 17% and 36 % higher odds of ICH, respectively. This relationship persisted in models that additionally adjusted for race/ethnicity, education, income, psychological status and social support for women who attended religious services at least once a week [Table]. Conclusion: Among women in the Women’s Health Study, compared to non-attenders women who attended religious services weekly displayed a 30% higher odds of ideal cardiovascular health, despite adjustment for social support and other risk factors. These data suggest that religious attendance may be beneficial to the cardiovascular health of older women via additional mechanisms beyond social support.
Abstract #254: The effect of oxygen deficiency on the outcome of radiation treatment in seven human tumor cell lines.
Authors: An Wouters, Bea Pauwels, Hilde Lambrechts, Greet Pattyn, Paul Meijnders, Jan Vermorken, Filip Lardon
Journal: Cancer Research (2009)

Introduction: Over the last decades, it has been well documented that poor oxygenation is a characteristic feature of most human solid tumors. In addition, the efficacy of radiotherapy is directly linked with an adequate oxygen tension and hypoxic regions often contain viable tumor cells that are intrinsically more radioresistant. In this study, the effect of severe hypoxia (anoxia,   Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 254.
A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection
Authors: Fiachra Humphries, Liraz Shmuel-Galia, Zhaozhao Jiang, Ruth Wilson, Philip Landis, Sze-Ling Ng, Krishna Mohan Parsi, Rene Maehr, John Cruz, Angel Morales, Joshi M. Ramanjulu, John Bertin, G. Scott Pesiridis, Katherine A. Fitzgerald
Journal: Science Immunology (2021)

Pharmacological activation of STING protects against SARS-CoV-2 infection.
Abstract 13133: Impact of Circadian Rhythm Disorders on Reparative Angiogenesis
Authors: Kazuhito Tsuzuki, Yuuki Shimizu, Zhongyue Pu, Junya Suzuki, Shukuro Yamaguchi, Rei Shibata, Toyoaki Murohara
Journal: Circulation (2020)

Introduction: Circadian rhythm disorder seen in shift-worker or jet-lag is major social health concerns in advanced industrialized countries. The aim of this study was to examine if circadian rhythm disorders would influence on angiogenesis and blood perfusion recovery in a mouse model of hind limb ischemia (HLI). Methods and Results: First, we established a jet-lag model in C57BL/6J (wild type; WT) mice (8-10 weeks old, N=10 for each) using a light controlled isolation box. Mice were exposed to advanced 8-hr light phase once every 4 days in a jet-lag group as previously described. Conversely, control mice were kept a regular condition of LD 12:12 (12-hr light and 12-hr dark). Then, we surgically induced HLI in each group. The results showed that the condition jet-lag deteriorated capillary formation detected by CD31-immunohistochemistry at post-operative day (POD) 28 and tissue blood perfusion recovery demonstrated by laser Doppler perfusion imaging (LDPI) in HLI. The expression of clock genes (i.e. Clock, Bmal1, Per2, Cry1 and 2 ) in ischemic muscles were regulated by jet-lag condition at POD7.Next, we examined whether inhibition of clock gene had any effects on angiogenesis. For this study, we focused on Cryptochrome ( Cry ), which is well known as one of the core-loop forming clock genes producing circadian rhythm in mammals. Our loss-of-function study revealed that the abilities of proliferation, migration and tube formation were significantly inhibited by CRY1 and CRY2 double knockdown in HUVECs. Interestingly, although the knockdown of CRY1 and CRY2 changed the mRNA expression of PERIOD2 , it did not affect those of BMAL1 and CLOCK in HUVECs. Finally, we tested if Cry1 and Cry2 double knockout ( Cry1/2 -DKO) mice of HLI models displayed worse blood perfusion recoveries with deterioration of angiogenesis. Cry1/2 -DKO mice were reported to display circadian rhythm disorder in previous reports. As results, compared with control WT mice, Cry1/2 -DKO mice revealed suppressed capillary density and tissue blood perfusion recovery in HLI model. Conclusion: Our data suggest that a maintenance of circadian rhythm plays an important role in reparative angiogenesis of the tissue ischemia model.
Abstract 15352: Age-associated Nuclear Remodeling May Contribute to Cardiac Dysfunction
Authors: Natalie J Kirkland, James D Hocker, Sebastian Preissl, Bing Ren, Rolf Bodmer, Adam J Engler
Journal: Circulation (2020)

Introduction: Cardiac performance depends on proper function of the extracellular matrix, cytoskeleton and nucleus to regulate systolic contraction and diastolic relaxation. As we age, the mechanical properties of these structures change, but their influence on tissue-level function is unclear. Nuclear Lamins (Lam), intermediate filaments that underly the nuclear envelope, change in expression and localization with age, leading to irregularly shaped nuclei. Mutations in LamA/C can cause premature aging and cardiomyopathy but whether Lamin changes with age contribute to cardiac dysfunction is unknown. Hence, we hypothesize that age-associated LamA/C reduction remodels nuclear shape, force propagation, and gene accessibility to reduce cardiac function. Methods: We profiled nuclear morphology and protein expression in hearts from two wildtype Drosophila melanogaster strains for up to 5 weeks, when median survival is less than 50%. We performed live imaging to assess heart performance in wildtype flies and flies with Lamin knock-down using the Gal4-UAS system. To profile chromatin accessibility changes we use an ATAC-seq protocol that we optimized for frozen heart nuclei. Results: Cardiomyocyte nuclei become smaller and more circular with age in contrast to skeletal nuclei across w 1118 and yw wildtype fly strains. Expression of both LamB and LamC ( Drosophila LamA/C) decrease with age and differentially regulate nucleus size and circularity. LamC knockdown, but not LamB, induces contractile dysfunction, measured by fractional shortening, at 1-week, and shortens lifespan. LamB and LamC knockdown also mimicked DNA decondensation observed in aged wildtype flies, suggesting that reduced DNA packaging could result from fewer contacts with the nuclear lamina. Thus, we developed a novel ATAC-seq pipeline that will identify how age-related nuclear architecture may influence the epigenome and contribute to pathogenic heart remodeling. Conclusions: Cardiomyocyte nuclei decrease in size and increase in circularity upon aging as a result of diminished Lamin expression. Loss of Lamin expression induces cardiac dysfunction. Our future work aims to elucidate the mechanism by which nuclear aging contributes to age-related cardiac dysfunction.
Prevalence of Immunosuppressive Drug Use Among Commercially Insured US Adults, 2018-2019
Authors: Beth I. Wallace, Brooke Kenney, Preeti N. Malani, Daniel J. Clauw, Brahmajee K. Nallamothu, Akbar K. Waljee
Journal: JAMA Network Open (2021)

This cross-sectional study uses direct pharmaceutical claims data from a commercial claims database to assess the use of 6 types of immunosuppressive drugs among commercially insured US adults in 2018 and 2019.
ストローク発生率およびCV死亡率の予測手段としてのAmbulatoryおよび臨床的BP:イタリア、日本および米国からの研究の分析
Authors: Schwartz Je, Imai Y, Verdecchio P, Pickering Tg, Ohkubo T, Hozawa A, Whyte J, L’Italien Gj, Lapuerta P, Chen Rs
Journal: Circulation (2002)
Sixty seconds on . . . calorie labelling
Authors: Gareth Iacobucci
Journal: BMJ (2021)

In a manner of speaking. As part of its wider obesity strategy, the government has decided to make it compulsory for larger businesses in England to put calorie information on the products they serve.

Only to products sold in shops. The government wants to go further, so has put legislation on the table1 to make calorie labelling on menus and …
Intention-to-Treat Analysis of Allogeneic Stem Cell Transplantation for Relapsed/Refractory Peripheral T-Cell Non-Hodgkin Lymphomas: A Large Italian Single-Center Experience
Authors: Nicoletta Cieri, Anna Dodero, Martina Pennisi, Alberto Mussetti, Lucia Farina, Anna Guidetti, Paolo Corradini
Journal: Blood (2017)
66P Baseline menopausal status, Ki-67 and stromal tumour-infiltrating lymphocytes (TILs) and association with outcome in triple-negative breast cancer (TNBC): Exploratory analysis in GeparSixto
Authors: S.I. Labidi-Galy, A. Schneeweiss, H.P. Sinn, J-U. Blohmer, L. Romanens, D-M. Zahm, J. Huober, D. Dohnal, T. Link, C. Hanusch, C. Jackisch, P.A. Fasching, C. Solbach, K.E. Rhiem, C. Denkert, K.E. Weber, B. Lederer, M. Untch, S. Loibl, J. Furlanetto
Journal: Annals of Oncology (2021)
Poster Exhibition : Effects of Amlodipine, Captopril and Bezafibrate on Splenic Histology and Splenocytes Apoptosis in Rats with Fatty Liver (초)
Authors: Maria Grozovski, Oron Herman M, T Rosenthal, B A Sela, G Amir, Zvi Ackerman
Journal: Clinical and Molecular Hepatology (2009)
Universal Genetic Testing to Identify Pathogenic Germline Variants in Patients With Cancer
Authors: Steven Sorscher
Journal: JAMA Oncology (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal