tbuckley/cabot-search huggingface dataset:
Editorial: Adverse reactions to beta-adrenergic blockade.
Journal: BMJ (1974)

3 she points out, that did not matter since she was already convinced that there is an overwhelming case for their re- placement.Apparently a small car adapted for driving by a disabled person is now cheaper than a three-wheeler and likely to become progressively more so.Add to this the noisi- ness, lack of comfort, and unreliability of the three-wheelers, and the fact that they cannot take passengers, and it is clear that the converted motor car is a far better vehicle for most disabled drivers.
Systemic sclerosis.
Authors: N. Rowell
Journal: BMJ (1968)

mOURNAL prevent the escape of gas.An enema admini- stered in the supine position may occasionally force fluid into the loop, but gas will be un- able to escape.In the early stages of the obstruction, peristaltic contractions in the gut proximal to the distended loop may also have a similar effect.However, if the patient is placed in the prone position the fluid-gas A) relationship will be reversed, thereby provid- ing a more favourable situation for the escape of gas from the distended loop.In a small number of patients a simple enema administered in the prone position has been successful in relieving a colonic volvulus, and it would certainly seem worth trying this pro- cedure in the early stage of a suspected volvulus.Moreover, this simple technique is also applicable to volvulus of the splenic flexure, which is out of reach of the sigmoido- scope.-Iam, etc.,
Lactic acidosis.
Authors: P von Wichert
Journal: BMJ (1971)

admission she was hypothermic (93 °F, 34GC, rectal), extremely dehydrated, blood pressure 120/ 80 mm Hg and pulse rate 66/minute.She was drowsy and confused.The plasma potassium was 5-2 mEq/l., urea 150 mg/ 100 ml, bicarbonate 5 mEq/l.and blood glucose 600 mg/ 100 ml.Arterial Po2 was 92 and Pco, 13 mm Hg with a pH of less than 6-8.The Ketostix test on
Novel insights into contact dermatitis
Authors: Jeanne Duus Johansen, Charlotte Menné Bonefeld, Jakob Ferløv Baselius Schwensen, Jacob Pontoppidan Thyssen, Wolfgang Uter
Journal: Journal of Allergy and Clinical Immunology (2022)

Contact dermatitis is a common disease that is caused by repeated skin contact with contact allergens or irritants, resulting in allergic contact dermatitis (ACD) and/or irritant contact dermatitis. Attempts have been made to identify biomarkers to distinguish irritant and allergic patch test reactions, which could aid diagnosis. Some promising candidates have recently been identified, but verification and validation in clinical cases still need to be done. New causes of ACD are constantly being recognized. In this review, 10 new contact allergens from recent years, several relating to anti-aging products, have been identified. Frequent allergens causing considerable morbidity in the population, such as the preservative methylisothiazolinone, have been regulated in the European Union. A significant drop in the number of cases has been seen, whereas high rates are still occurring in other areas such as North America. Other frequent causes are fragrance allergens, especially the widely used terpenes and acrylates found in medical devices for control of diabetes. These represent unsolved problems. Recent advances in immunology have opened the way for a better understanding of the complexity of contact dermatitis, especially ACD—a disease that may be more heterogenous that previous understood, with several subtypes. With the rapidly evolving molecular understanding of ACD, the potential for development of new drugs for personalized treatment of contact dermatitis is considerable.
SOCIETY NEWS
Authors: Oliver Bögler
Journal: Neuro-Oncology (2008)

Cancer in the Nervous System, 2nd Edition, Now Available OnlineDear Readers, Cancer in the Nervous System, 2nd edition, is now available online at http://www.soc-neuro-onc .org,under "Literature and Book Review."This is an online version of the textbook I originally conceived and developed to address the many and varied clinical problems patients with cancer in the nervous system encounter.In response to our colleagues' preference for online access, the contents of the 2002 edition of the book were converted into a searchable Adobe PDF document and made available for free.The online version of Cancer in the Nervous System will be valuable to the physicians, nurses, psychologists, and all who care for people suffering from cancer that affects the central nervous system.Though this online book may not contain all the latest and most up-to-date thinking in the field, we do believe that much of the basic information and concepts in the book are correct, and we hope that the online book will stimulate colleagues with an interest and expertise in neuro-oncology to write updates.Our intent is to add these updates to the online book as supplements to the existing chapters.In some cases we would be willing to replace some of the current online chapters with updated chapters.Authors interested in providing new and updated content can submit their potential entries to me at vlevin@mdanderson.org.
Non-oncogene Addiction to SIRT5 in Acute Myeloid Leukemia
Authors: Meng Li, Ari M. Melnick
Journal: Blood Cancer Discovery (2021)

In this issue of Blood Cancer Discovery, Yan and colleagues discovered that mitochondrial deacylase, SIRT5, is required in AML cells to support mitochondrial oxidative phosphorylation, maintain redox homeostasis, and drive glutaminolysis. The new SIRT5 inhibitor, NRD167, can efficiently target SIRT5 in AMLs at micromolar range and may constitute a novel therapeutic approach to improve clinical outcomes of patients with AML.See related article by Yan et al., p. 266.
ESGE News and Upcoming Events February 2021
Journal: Endoscopy (2021)

A huge thank you to everyone who submitted their abstracts to ESGE Days 2021. Despite the challenges faced in 2020, and the decision to make the 2021 congress 100 % virtual, ESGE was thrilled to receive 781 abstract submissions. These entries came from a total of 53 different countries, demonstrating what a rich international knowledge base ESGE has. A new abstract topic was introduced this year – Covid19 – and 40 entries on this theme were submitted.
Tamoxifen
Authors: Sewa S. Legha
Journal: JAMA (1979)

Tamoxifen citrate (Nolvadex [Great Britain]; no comparable US product) is a recently developed antiestrogen with significant activity against metastatic breast cancer in postmenopausal women. We investigated its usefulness in breast cancer patients after conventional endocrine therapy and combination chemotherapy had failed. Of the 50 evaluable patients, four (8%) achieved a complete remission, 14 (28%) achieved a partial remission, and ten showed a less than partial response or stabilization of their disease. Median duration of response was eight months, and the survival of responders was significantly prolonged compared to that of the nonresponders. Side effects of the treatment were mild. These results demonstrate that tamoxifen offers the best choice of therapy for patients with metastatic breast cancer after conventional endocrine therapy and combination chemotherapy have failed. (<i>JAMA</i>242:49-52, 1979)
Arctic willy.
Authors: S. Travis, D. Roberts
Journal: BMJ (1989)

Bartholomew's.No hypothesised factors could explain these differences, which persisted after complex corrections for medical school intake.Six medical schools explicitly included nutrition in their curricula.A cross tabulation between these schools and the rest and between a higher than average and lower than average production of nutritionally aware graduates gave x2=001, df=l; NS.Pearson's correlation coefficient between teaching time and number of contributors was -01.These data suggest a likely negative relation between these variables.The number of medically qualified contributors to the Good Food Guide varied with date of graduation and was 31 for 1941-50, 27 for 1951-60, 24 for 1961-70, 17 for 1971-80, and seven for 1980-7 (one unknown).A one sample test showed that the contributors were significantly unevenly distributed by graduation date (X2= 16 83, df=4; p<001).Inspection showed that more older graduates than younger ones were nutri- tionally aware, despite having had little, ifany, teaching in nutrition.
Concurrent Care
Journal: Diabetes Care (1991)

Concurrent Care Diabetes mellitus is a disease that requires frequent medical attention.The hospitalization of a person with diabetes for an incurrent illness mandates ongoing medical evaluation and treatment of the diabetic state.Such close attention is best performed by a physician with special interest and expertise in diabetes.Thus, quality care for the hospitalized patient with diabetes usually requires concurrent care by a physician expert in diabetes and by a physician responsible for the patient's intercurrent illness.
Registry pools reports on ocular side effects
Authors: H. Cole
Journal: JAMA (1985)

"Ocular side effects are one of the more common reasons for a drug in preclinical trials to never reach the marketplace," reports Frederick T. Fraunfelder, MD, professor and chair, Department of Ophthalmology, Oregon Health Sciences University, Portland. Of course, some drugs with known or unknown ocular side effects are marketed; the adverse reaction may be experienced by relatively few patients receiving the drug, and the significance may not be readily apparent to a solo practitioner who has seen only one case. In an effort to pool information from individual practitioners on both ocular side effects of systemic medications and systemic response to ocular medications, a registry was established in 1975. Funded by the Food and Drug Administration and in collaboration with the American Academy of Ophthalmology, the National Registry of Drug Induced Ocular Side Effects (in Portland, Ore) surveys ophthalmologists, the drug industry, and paramedical personnel in the United States
Intestinal Obstruction
Authors: E. Andrew
Journal: BMJ (1878)

QURF.4 S.pt.M, 47t hou after deatb, the body was found to be fat, nd tere was asmall bruise under the left eye.The belly was somewhat prominen, but not hard.There was blood, both fluid and clotted, in the abdomen.The spleen had a long perpendicular rent on the inner side, extending from
An mTOR siRNA‐Loaded Spermidine/DNA Tetrahedron Nanoplatform with a Synergistic Anti‐Inflammatory Effect on Acute Lung Injury
Authors: Chaowang Huang, Qianyi You, Jing Xu, Di Wu, Huaping Chen, Yuhang Guo, Jiancheng Xu, Mingdong Hu, Hang Qian
Journal: Advanced Healthcare Materials (2022)

Acute lung injury (ALI) is characterized by severe inflammation and damage to the lung air-blood barrier, resulting in respiratory function damage and life-threatening outcomes. Macrophage polarization plays an essential role in the occurrence, development, and outcome of ALI. As drug carriers, self-assembled DNA nanostructures can potentially overcome the drawbacks and limitations of traditional anti-inflammatory agents owing to their nontoxicity, programmability, and excellent structural control at the nanoscale. A small interfering RNA (siRNA) and drug dual therapy nanoplatform are proposed and constructed here to combat ALI. The nanoplatform consists of a spermidine-assembled DNA tetrahedron and four mammalian target of rapamycin siRNAs. Spermidine serves as a mediator of drug delivery vehicle synthesis and a drug that alters macrophage polarization. Both spermidine and siRNA exert anti-inflammatory effects in vitro and in vivo by regulating the macrophage phenotype. More importantly, these factors exhibit a synergistic anti-inflammatory effect by promoting macrophage autophagy. For the first time, an anti-inflammatory dual therapy strategy that uses self-assembled DNA nanostructures as nontoxic, programmable delivery vehicles is proposed and demonstrated through this work. Future work on utilizing DNA nanostructures for the treatment of noncancerous diseases such as ALI is highly promising and desirable.
Edward Jenner and his "temple of vaccinia".
Journal: BMJ (1966)

Edward Jenner and his " Temple-of Vaccinia " Edward Jenner was born at Berkeley in Gloucestershire in 1749 and lived there for most of his life.Though he also spent some time in Cheltenham as well (see B.M.7., 8 October, p. 899), most of his work-and particularly that on vaccination-was done at Berkeley.Jenner's old house, the Chantry, is now the vicarage, and the summerhouse he called the " Temple of Vaccinia " is in its garden.A group of doctors in the West Country have recently formed a Jenner Trust, which has three main aims: to restore the Temple of Vaccinia; to ensure that it is kept in permanent repair ; and to form a small museum in Phipps's house, which Jenner built for James Phipps-the boy who at the age of 8 was the first person to be vaccinated.Phipps's cottage.Besides representatives from Berkeley itself, general practi- tioners, and Gloucester Royal Infirmary, members of the Trust also include doctors representing the Royal Society, the Royal College of Physicians, the Royal College of Surgeons, and the College of Pathologists.The first meeting of the Trust, which has already received gifts of over £100, is to be held in Bristol on 23 November, and an appeal for funds is to be launched.The secretary of the Trust is Dr.
Nervous and Mental Diseases.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erythromycin ethylsuccinate hepatotoxicity
Authors: D. Sullivan
Journal: JAMA (1980)

ERYTHROMYCIN is available to the clinician in several forms, each of which differs primarily because of a single substitution at the two-prime position of the desoamine moiety. All commonly available forms can be associated with mild abdominal cramping, nausea and vomiting, diarrhea, and hypersensitivity reactions. Hepatotoxicity presenting dramatically with fever and abdominal pain suggesting an acute surgical abdomen has been associated only with the estolate form of the antibiotic. The following case illustrates a similar syndrome related to the ethylsuccinate preparations.<sup>1</sup> <h3>Report of a Case</h3> A 45-year-old woman was given erythromycin ethylsuccinate (EES-400), 400 mg orally four times daily, after two weeks of rhinitis and productive cough. On the ninth day of therapy, the patient had sudden onset of severe right upper quadrant pain, fever (temperature, 40 °C), shaking chills, nausea, and vomiting. Erythromycin administration was discontinued. As the acute symptoms lessened over the next 24 hours, dark urine
Haemophilus epiglottitis.
Authors: K D Roberts
Journal: BMJ (1972)

troduction of modern, malleable fibre-optic endoscopes has been accompanied by a fall in the incidence of oesophageal injuries.However, even the most skilled endoscopist using the latest apparatus must still be ever awake to the risk of oesophageal damage."Smith and Tanner's' figure of one per- foration in every 300 gastroscopies and one perforation in every 100 oesophagoscopies refers to the use of rigid instruments; Arigae collected information on 123,900 gastro- scopies.The perforation rate with rigid in- struments was 0-065 % and with early fibre- scopes 0 03%.Its apparent safety is con- tributing to the rapid increase in the num- ber of fibre-endoscopies being performed in patients of all ages by endoscopists of varied experience.Instruments are becoming more complex and investigators more ambitious.It is therefore important to obtain accurate and up-to-date knowledge of the incidence of all the complications of modem fibre- endoscopy.We hope that this information will shortly be available from a survey being undertaken among members of the British Society for Digestive Endoscopy.-Weare, etc.,
CONSULTANT, GENERAL PRACTITIONER, OR HALF-AND-HALF?
Journal: BMJ (1910)

z iot 84In the sabe number Dr. Cooper writes: (b) Indigents; that is, those who have ordinarily not enough to live on . . .I would fix the wage limit of this class at £1 a week.Any one earning on an average less than this ... isj in my opinion, quite unable to pay aniything towards the cost of medical attendance.... Nine-tenths of my patients earn from 15s. to 18s. a week, making a little more in harvest, but losing time whenever the weather is unfavourable.Yet they pay me, and pay well, and readily.And Dr. Cooper would sweep them all, and with them all the agricultural workmen, in to the arms of the Poor Law.Is the publication of such opinions as these going to help the general practitioner?I doubt it.Surely it is not too much to ask that when a man is about to put out such ideas in the organ of the profession he should take the trouble to inquire what the effect may
From the Centers for Disease Control and Prevention. Public health focus: physical activity and the prevention of coronary heart disease
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
INTESTINAL OBSTRUCTION
Authors: John A. Hartwell
Journal: The Journal of Experimental Medicine (1913)

Whipple, Stone, and Bernheim I studied the cause of death in dogs with high intestinal obstruction, by producing a closed loop of the duodenum, beginning just below the pancreatic ducts and ending beyond the suspensory ligament.This portion was isolated from • the remainder of the intestinal tract by tying a heavy ligature tightly at these two points, and burying it under an inverted layer of the peritoneum.A gastro-enterostomy was then done.Dogs so treated died in from thirty-six to seventy-two hours.The authors inferred from this that there developed in the closed loop a poisonous material, the absorption of which caused death.Since the closed loop contained neither gastric secretion, bile, nor pancreatic juice, the conclusion seemed inevitable that some alteration in the loop function was responsible for death.A series of careful and well controlled experiments was then undertaken to study the nature, and if possible, to determine the source of the poison.The method employed was to-produce the isolated loop, collect the cor~tents, sterilize them by heating to 60 ° C., filtering them, and then, after autolysis, to inject them into a healthy dog, intravenously, subcutaneously, or intraperitoneally.It was demonstrated in this way that dogs so injected died promptly.Further, the authors were unable to isolate such a poisonous material from the normal intestine by any method o f treatment; and if the mucosa of the loop were first destroyed by a fluoride, the poisons did not appear.Lastly, some dogs died within a few days, when the loop was drained externally, there being an absorption directly from the mucosa, and not from the lumen.
THE PATHOLOGIC ANATOMY OF PARATYPHOID FEVER.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Masthead
Authors: Paul Berk, York Neu, Andres Blei, Herbert Bonkovsky, Worcester Massachusetts, Adrian Di Bisceglie, Maryland Bethesda, A Michael, Robert Glickman, Ann Boston, Albert Jones, Sun Francisco, Willis Maddrey, Esteban Dallas, Kunio Mezey, Allan Wolkoff, New York, Raymond Koff, T Liang, Irwin Arias, Michelle Britton, Kerry Carlyle, John Gollan, Massach Boston, Michael Sorrell, Jay Hoofnagle, D Bissell, Eugene Schiff, Florrda Chairman, John Vierling, Los Angeles, Dawd California, Esteban Mezey, Baltimore Maryland, Anthony Tavill, Nicholas Cleveland, Rochester Larusso, Minnesota Kaplowitz, S Angeles, Scott California, Sun Friedman, Joseph Francisco, Minnesota Bloomer, Glen Klein, Maryland Arm, Steven Boston, Sun Schenker, Anna Antonio
Journal: Hepatology (1994)