Rosuvastatin Myotoxicity After Starting Canagliflozin Treatment
Authors: Rao N.V.S. Mamidi, Damayanthi Devineni, Don Sun, Yshai Yavin, Norman Rosenthal
Journal: Annals of Internal Medicine (2021)

LettersMarch 2021Rosuvastatin Myotoxicity After Starting Canagliflozin TreatmentRao N.V.S. Mamidi, PhD, Damayanthi Devineni, PhD, Don Sun, MD, Yshai Yavin, MBChB, Norman Rosenthal, MDRao N.V.S. Mamidi, PhDJanssen Research & Development, Raritan, New JerseySearch for more papers by this author, Damayanthi Devineni, PhDJanssen Research & Development, Raritan, New JerseySearch for more papers by this author, Don Sun, MDJanssen Research & Development, Raritan, New JerseySearch for more papers by this author, Yshai Yavin, MBChBJanssen Research & Development, Raritan, New JerseySearch for more papers by this author, Norman Rosenthal, MDJanssen Research & Development, Raritan, New JerseySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L20-1455 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR: Brailovski and colleagues (1) report the first drug–drug interaction (DDI) between canagliflozin and a statin. However, no myotoxicity signal was seen in the clinical development program (which consisted of >19 000 participants receiving canagliflozin) or during postmarketing use (which totaled more than 4.9 million patient-years of exposure). This program included the long-term CREDENCE study in patients with type 2 diabetes and stage 2 to 3 chronic kidney disease and the CANVAS (CANagliflozin cardioVascular Assessment Study) Program in patients with type 2 diabetes at high cardiovascular risk, both with approximately 70% concomitant statin use ( >9% received rosuvastatin; data on ...References1. Brailovski E, Kim RB, Juurlink D. Rosuvastatin myotoxicity after starting canagliflozin treatment: a case report [Letter]. Ann Intern Med. 2020;173:585-7. doi:10.7326/L20-0549 LinkGoogle Scholar2. Birmingham BK, Bujac SR, Elsby R, et al. Rosuvastatin pharmacokinetics and pharmacogenetics in Caucasian and Asian subjects residing in the United States. Eur J Clin Pharmacol. 2015;71:329-40. [PMID: 25630984] doi:10.1007/s00228-014-1800-0 CrossrefMedlineGoogle Scholar3. Mamidi RNVS, Dallas S, Sensenhauser C, et al. In vitro and physiologically-based pharmacokinetic based assessment of drug-drug interaction potential of canagliflozin. Br J Clin Pharmacol. 2017;83:1082-96. [PMID: 27862160] doi:10.1111/bcp.13186 CrossrefMedlineGoogle Scholar4. Elsby R, Martin P, Surry D, et al. Solitary inhibition of the breast cancer resistance protein efflux transporter results in a clinically significant drug-drug interaction with rosuvastatin by causing up to a 2-fold increase in statin exposure. Drug Metab Dispos. 2016;44:398-408. [PMID: 26700956] doi:10.1124/dmd.115.066795 CrossrefMedlineGoogle Scholar5. Prueksaritanont T, Chu X, Evers R, et al. Pitavastatin is a more sensitive and selective organic anion-transporting polypeptide 1B clinical probe than rosuvastatin. Br J Clin Pharmacol. 2014;78:587-98. [PMID: 24617605] doi:10.1111/bcp.12377 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Janssen Research & Development, Raritan, New JerseyDisclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L20-1455. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoRosuvastatin Myotoxicity After Starting Canagliflozin Treatment: A Case Report Eugene Brailovski , Richard B. Kim , and David Juurlink Rosuvastatin Myotoxicity After Starting Canagliflozin Treatment Eugene Brailovski , Richard B. Kim , and David Juurlink Rosuvastatin Myotoxicity After Starting Canagliflozin Treatment Ahmad Alamer , Charisse Te , and Maryam T. Fazel Metrics March 2021Volume 174, Issue 3Page: 431-432 ePublished: 16 March 2021 Issue Published: March 2021 Copyright & PermissionsCopyright © 2021 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...