tbuckley/cabot-search huggingface dataset:
Volumetric Analysis and Three-Dimensional Glucose Metabolic Mapping of the Striatum and Thalamus in Patients With Autism Spectrum Disorders
Authors: M. Mehmet Haznedar, Monte S. Buchsbaum, Erin A. Hazlett, Elizabeth M. LiCalzi, Charles Cartwright, Eric Hollander
Journal: American Journal of Psychiatry (2006)

In patients with autism, behavioral deficits as well as neuroimaging studies of the anterior cingulate cortex suggest ventral rather than dorsal striatal and thalamic abnormalities in structure and function. The authors used imaging studies to map volumetric and metabolic differences within the entire dorsoventral extent of the striatum and thalamus.Magnetic resonance imaging (MRI) and positron emission tomography (PET) were used to measure volumes and metabolic activity in the thalamus, caudate, and putamen in 17 patients with autism or Asperger's disorder and 17 age- and sex-matched comparison subjects. Subjects performed a serial verbal learning test during the [(18)F]-fluorodeoxyglucose uptake period. The regions of interest were outlined on contiguous axial MRI slices. After PET/MRI coregistration, region-of-interest coordinates were applied to the PET scan for each individual. Between-group differences in metabolism were assessed by three-dimensional statistical probability mapping.The patients with autism spectrum disorders had greater volumes of the right caudate nucleus than comparison subjects as well as a reversal of the expected left-greater-than-right hemispheric asymmetry. Patients also had lower relative glucose metabolic rates bilaterally in the ventral caudate, putamen, and thalamus. Patients with autism had lower metabolic activity in the ventral thalamus than those with Asperger's disorder, but they did not differ from comparison subjects in metabolic activity in the caudate nucleus.These results are consistent with a deficit in the anterior cingulate-ventral striatum-anterior thalamic pathway in patients with autism spectrum disorders. The results also suggest an important role for the caudate in helping support working-memory demands.
House for Sale
Authors: H. CLARKE
Journal: Annals of Internal Medicine (1981)

Ad Libitum1 June 1981House for SaleH. CLARKE, M.D.H. CLARKE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-6-825_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe old woman and I exchanged autobiographiesAs we moved from room to roomIn the white cottage,With the opening of each doorI was led in on a glossary of eventsThinly outlined in old photographsNow grown yellow with the years,The sound of the clockAdded to the silence of the gardenias,Silver tea sets and delicate embroideriesA thirty calibre deer rifle in a cornerSeemed there to fit and blend togetherLike pieces from a puzzleTheirs had been a conversation of flowersThey had parted company that DecemberBut the garden had been... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: St. John's, Newfoundland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1981Volume 94, Issue 6Page: 825-825KeywordsFirearm injuriesTea ePublished: 1 December 2008 Issue Published: 1 June 1981 PDF downloadLoading ...
Incorrect Table Entries
Journal: JAMA (1998)

Merck & Co, Inc, the makers of Zocor, provided funding for the mailing.Wal-Mart's concern for their customers' health is certainly a worthy gesture, but it appears that the true motivation for this campaign lies in the drawers of their cash registers.It was not very long ago that Miles Pharmaceutical had to pay 11 states $605 000 because of its program of paying pharmacists who were able to switch patients to its Adalat CC (nifedipine).Miles also reportedly had paid pharmacists for the names of their patients. 1 Since the technology obviously exists to allow the pharmacist to track medication adherence, I would suggest that if Wal-Mart truly wishes to help its customers, it should review the database for all patients taking cholesterol-lowering agents on a regular basis.Limiting this service to a select group because of funding from a pharmaceutical company is, in my view, unethical and should not be supported by physicians.
Effects of Selective Left Ventricular Bypass
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the NIH: Clinical trials provide new information
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Cheatle-Henry Approach for Inguinal Herniotomy in Infants and Children
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Munchausen
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
'Tricks' of trade aid kidney transplants
Authors: E. Blume
Journal: JAMA (1983)

Monoclonal antibodies directed against specific T-lymphocyte antigens, donor-specific blood transfusions, and cyclosporine are permitting many patients to be successfully transplanted with poorly matched kidneys, according to reports at a recent National Kidney Foundation meeting in Washington, DC. Thus, use of these methods is further improving graft survival rates. (Even between 1977 and 1980—before these methods came into general use—graft survival rates increased substantially. In an interview with<i>JAMA</i>MEDICAL NEWS, Henry Krakauer, MD, PhD, noted that rates increased from 52% to 61% at one year for cadaveric transplants and from 70% to 82% for grafts from living related donors. Krakauer, of the Genetics and Transplantation Branch, National Institute of Allergy and Infectious Diseases, Bethesda, Md, derived his figures from various sources, including raw data from the Health Care Financing Administration.) Because mature T lymphocytes appear to be the principal effector cells in most cases of graft rejection, eliminating or suppressing
Urinary Gnathostomiasis
Authors: James J. Horohoe
Journal: JAMA (1984)

WITH THE recent immigration of Indochinese refugees into the United States, parasitic infection indigenous to this population is being recognized more frequently.<sup>1-4</sup>We report a case of urinary tract gnathostomiasis in a Laotian refugee who immigrated to the United States in 1979. To our knowledge, this is the first such case to be reported in this country and only the fifth on record.<sup>5</sup>The parasite, identified as<i>Gnathostoma spinigerum</i>, was also somewhat unusual in that it was a nearly mature male worm. This form of larvae migrans more commonly yields smaller, thirdstage larvae somewhere on the body in subcutaneous tissue.<sup>6</sup> <h3>Report of a Case</h3> A 46-year-old native of Laos immigrated to the United States from a refugee camp in Thailand. His medical history was unremarkable and he was in good health until early July 1982, when he had bilateral costovertebral pain, gross hematuria, terminal dysuria, and temperature
Current Comment
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Old Men
Authors: ABRAHAM VERGHESE
Journal: Annals of Internal Medicine (1984)

Ad Libitum1 September 1984Old MenABRAHAM VERGHESE, M.D.ABRAHAM VERGHESE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-3-407_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptI will never forget the face of the wizened old farmer as he stood in the rural clinic. He wore only a loincloth and carried a cane. He had been waiting patiently and now, as his turn came, he saluted me by bringing his palms together and bowing gently, his eyes lowered. It was not an obsequious gesture but a dignified salute. The clinic in India was miles from any sort of sophisticated care, my armamentarium consisted of my senses for diagnosis, and a scabicidal ointment and a plentiful supply of vitamin A and sulfa tablets for treatment. My compounder... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ABRAHAM VERGHESE, M.D.Affiliations: Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1984Volume 101, Issue 3 Page: 407-407 Keywords Ointments Vitamin A ePublished: 1 December 2008 Issue Published: 1 September 1984 PDF downloadLoading ...
In Memoriam, Arlette Darfeuille-Michaud, PhD
Authors: Jennifer Raisch, Adeline Sivignon, Benoit Chassaing, Pierre Lapaquette, Sylvie Miquel, Frédéric Carvalho, Nathalie Rolhion, Marie-Agnès Bringer, Nicolas Barnich, Jérôme Boudeau, Patrick Di Martino
Journal: Gut (2014)

following a 15-month battle against cancer
Contents
Authors: K Quinn, J Tabibian, S Sweetser, M Hasan, A Ponte, R Pinho, J Carvalho, C Triantos, I Yoo, H Chun, B Keum, M Vela, K Patel, S Cummings, J Sellin, L Scott, H El-Serag, D Francis, M Vaezi, Y Wang, L Tai, E Yazaki, J Jafari, R Sweis, E Tucker, K Knowles, J Wright, S Ahmad, M Kasi, K Hamlett, M Fox, D Sifrim, H Song, M Held, S Sandin, H Rautelin, M Eliasson, S Söderberg, G Hallmans, L Engstrand, O Nyrén, W Ye, R Genta, M Rugge, A Sabatino, U Volta, C Salvatore, P Biancheri, G Caio, R De Giorgio, M Stefano, G Corazza, S Shiota, R Reddy, A Alsarraj, D Graham, K Frankwich, J Egnatios, M Kenyon, T Rutledge, P Liao, S Gupta, K Herbst, A Zarrinpar, C Gilletta, M Lewin, A Bourrier, I Nion-Larmurier, S Rajca, L Beaugerie, H Sokol, B Pariente, P Seksik, J Cosnes, S Oza, V Pabby, L Dodge, V Moragianni, M Hacker, J Fox, K Correia, S Missmer, Y Ibrahim, A Penzias, R Burakoff, S Friedman, A Cheifetz, F Bholah, D Chowdhury, A Sanders, E Mooiweer, A Van Der Meulen
Journal: Clinical Gastroenterology and Hepatology (2015)
Reversal of behavioral changes in rats subjected to portacaval shunt with oral neomycin therapy
Authors: H Conjeevaram
Journal: Hepatology (1994)

The portacaval shunt rat is often used as a model of human portal-systemic encephalopathy, but its relevance to human portal-systemic encephalopathy remains uncertain. Specifically, it has not been demonstrated that the behavioral changes seen in this model respond to measures known to improve portal-systemic encephalopathy in human subjects. Accordingly, the aim of this study was to establish whether neomycin (an effective treatment for portal-systemic encephalopathy in human beings) added to the drinking water of rats subjected to portacaval shunt reversed or ameliorated the reduction in spontaneous motor activity, which represents a measure of encephalopathy in this animal model. A randomized, placebocontrolled crossover design was used, with each animal serving as its own control. After establishment of baseline activities, 12 rats with portacaval shunt and 12 sham-operated rats were divided into two equal groups: Group A animals received neomycin for 1 wk; this was followed by 1 wk off neomycin; in group B rats, the sequence was reversed. Spontaneous intake of neomycin for 7 days at doses comparable to human usage (0.1 to 0.2 gm/kg/day) was associated with a significant increase in spontaneous motor activity in rats subjected to portacaval shunt (26.4% in group A, 66.3% in group B; p<0.01 for each protocol) with no significant effect in sham-operated animals. Withdrawal of neomycin resulted in reversal of this effect in group A rats subjected to portacaval shunt. Similar significant improvements for exploratory activity as measured on the basis of nose-hole pokes was also seen in rats subjected to portacaval shunt and given neomycin. These neomycin-associated changes in the motor activity of rats subjected to portacaval shunt could not be attributed to any effect of neomycin on serum ammonia level. These findings support the concept that the rat subjected to portacaval shunt is a valid model of human portal-systemic encephalopathy that can be used to explore the pathophysiology of this syndrome. (HEPATOLOGY 1994;19:1245–1250.)
A MEMORABLE PATIENT
Authors: J. Zorab
Journal: BMJ (1996)

<h3>SUMMARY</h3> The 1000 Genomes Project (1kGP) is the largest fully open resource of whole genome sequencing (WGS) data consented for public distribution of raw sequence data without access or use restrictions. The final release of the 1kGP included 2,504 unrelated samples from 26 populations and was based primarily on low coverage WGS. Here, we present a new, <i>high coverage</i> 3,202-sample WGS 1kGP resource, sequenced to a targeted depth of 30X using the Illumina NovaSeq 6000 system, which now includes 602 complete trios. We performed SNV/INDEL calling against the GRCh38 reference using GATK’s HaplotypeCaller, and generated a comprehensive set of SVs by integrating multiple analytic methods through a sophisticated machine learning model. We make all the data generated as part of this project publicly available and we envision it to become the new de facto public resource for the worldwide genomics and genetics community.
Disclosure
Authors: John Chamberlain
Journal: Annals of Internal Medicine (2010)

On Being a Doctor1 June 2010DisclosureJohn Chamberlain, MDJohn Chamberlain, MDFrom University of Rochester, Rochester, NY 14626.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-11-201006010-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail It was Thursday, and I was late. The usual delays. I couldn't wait for the elevator. I'd taken the stairs. I felt overwhelmingly weary. My mind pleaded for sleep, my spirit for absolution. My heart wouldn't stop racing. Must be the stairs. I sought balance by focusing on my breathing and the moment. Sun shone through the windows as I passed open doors, its warmth lost on me. Glancing smiles faded as I passed the nurses' station. Did I look that glum? It had been a long 2 days.His wife had called on Tuesday. He was having atypical chest ... Author, Article, and Disclosure InformationAffiliations: From University of Rochester, Rochester, NY 14626.Corresponding Author: John Chamberlain, MD, University of Rochester, 3101 Ridge Road West, Rochester, NY 14626. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 2010Volume 152, Issue 11Page: 751-752KeywordsChartsComputed axial tomographyDiagnostic radiologyEmotionsHeartIschemiaLiver diseasesPancreatitisRadiologistsThorax ePublished: 1 June 2010 Issue Published: 1 June 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Cancer Treatment Symposia (Volume 2, 1983): “Workshop on Patterns of Failure After Cancer Treatment” Available
Journal: JNCI Journal of the National Cancer Institute (1984)

Cancer Treatment Symposia (Volume 2, 1983): “Workshop on Patterns of Failure After Cancer Treatment” Available Get access JNCI: Journal of the National Cancer Institute, Volume 72, Issue 3, March 1984, Page 770, https://doi.org/10.1093/jnci/72.3.770 Published: 01 March 1984
Classified Advertising
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
On Rare Diseases and Exceptional Symptoms
Authors: J. Hutchinson
Journal: BMJ (1888)

in disordered t.hermolysis without other change, the temperature mi*ht rise and remvain hliglh.But there was good ground for the behXt f that suclh noni-I,yrexial elevation of temperature was not in itself danigerols.Take, for example, the cases of aseptic opera- tion, (lescribed 1b Volkniiann annd other surgeons, in whlich a tem- peratuire of 104"or 1t'°wais aCcoml)anie(l by no loss of appetite, nio distress, ino symiptom such as could be called characteristically febrile.Many of the current beliefs as to the beneficial effects, func- tiona;ll and(I texturial, of mere hiigh1 temperatutre were based on ex- perimenits in wlicil aInimals were forcibly overheated.These expelriment,s were examinied critically, ndi in the liglht of fresh researclie;.suchl ais those of Naunyn, and Welch of Baltimore,shown-j to be calpble of otlher ilnterpretation.With due precau- tioins, suchl animals ctoild he k-ept in comifort and withiout per- maneiit dlamage, for days or weeks, their rectal temperatuire being, on the average, 106' .Danger dlid not arise till a muclh highier poinit was meached; and tlheni the evidence proved that the over- strain oni tlhei tlhermal system broke down the regulating mechlanism, anil conmplete thermal dissolutionl or hyperpyrexia set in,The phenomeni of relapsing fever were adlduced as bearing in the same direction.In thiis disease, the subjects of wlich were often weak and anfxic, temiperatures of 1070, enduring for five or six days, were common, and were tolerated well, as was shown by, among otlher things, the small mortality (4 or 5per cent.).Tlhe conclusion iultimately reached was: That highi temperature in itself wvas not proven to be salutary, neither was it in itself the efficient cause of ILll the morbid phenomena commonly described as febrile.