tbuckley/cabot-search huggingface dataset:
Universal Suicide Prevention for Health Care Professionals—Reply
Authors: Yisi D. Ji, Faith C. Robertson, Nisarg A. Patel
Journal: JAMA Surgery (2020)

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Neural Remodeling and Myocardial Infarction: The Stellate Ganglion as a Double Agent⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Authors: Olujimi A. Ajijola, Kalyanam Shivkumar
Journal: Journal of the American College of Cardiology (2012)
Coronary Plaque Neovascularization and Hemorrhage: A Potential Target for Plaque Stabilization?⁎⁎Editorials published in JACC: Cardiovascular Imaging reflect the views of the authors and do not necessarily represent the views of JACC: Cardiovascular Imaging or the American College of Cardiology.
Authors: Aloke V. Finn, Rakesh K. Jain
Journal: JACC. Cardiovascular imaging (2010)
Letter to the Editor: Living Donor Liver Transplantation or Deceased Donor Liver Transplantation in High Model for End‐Stage Liver Disease Score—Which Is Better?
Authors: Anand V. Kulkarni, Pramod Kumar, Mithun Sharma, Balachandran Menon, D. Nageshwar Reddy, P. Nagaraja Rao
Journal: Hepatology (2020)
Covid-19 has harmed poorest countries the most across Asia Pacific, says OECD
Authors: Lynn Eaton
Journal: BMJ (2020)

Covid-19 has harmed poorest countries the most across Asia Pacific, says OECD Lynn EatonThe covid-19 pandemic has highlighted existing gaps in healthcare within the Asia Pacific region and reinforced differences between rich and poor, a report from the Organisation for Economic Co-operation and Development (OECD) has concluded.
Post-Translational Modifications of G Protein–Coupled Receptors Control Cellular Signaling Dynamics in Space and Time
Authors: Anand Patwardhan, Norton Cheng, JoAnn Trejo
Journal: Pharmacological Reviews (2020)

G protein–coupled receptors (GPCRs) are a large family comprising &gt;800 signaling receptors that regulate numerous cellular and physiologic responses. GPCRs have been implicated in numerous diseases and represent the largest class of drug targets. Although advances in GPCR structure and pharmacology have improved drug discovery, the regulation of GPCR function by diverse post-translational modifications (PTMs) has received minimal attention. Over 200 PTMs are known to exist in mammalian cells, yet only a few have been reported for GPCRs. Early studies revealed phosphorylation as a major regulator of GPCR signaling, whereas later reports implicated a function for ubiquitination, glycosylation, and palmitoylation in GPCR biology. Although our knowledge of GPCR phosphorylation is extensive, our knowledge of the modifying enzymes, regulation, and function of other GPCR PTMs is limited. In this review we provide a comprehensive overview of GPCR post-translational modifications with a greater focus on new discoveries. We discuss the subcellular location and regulatory mechanisms that control post-translational modifications of GPCRs. The functional implications of newly discovered GPCR PTMs on receptor folding, biosynthesis, endocytic trafficking, dimerization, compartmentalized signaling, and biased signaling are also provided. Methods to detect and study GPCR PTMs as well as PTM crosstalk are further highlighted. Finally, we conclude with a discussion of the implications of GPCR PTMs in human disease and their importance for drug discovery. <h3>Significance Statement</h3> Post-translational modification of G protein–coupled receptors (GPCRs) controls all aspects of receptor function; however, the detection and study of diverse types of GPCR modifications are limited. A thorough understanding of the role and mechanisms by which diverse post-translational modifications regulate GPCR signaling and trafficking is essential for understanding dysregulated mechanisms in disease and for improving and refining drug development for GPCRs.
Abstract 15864: Whole Body Periodic Acceleration (pGz); A Novel Therapeutic Approach in Dystrophin <sup>-/-</sup> Utrophin <sup>-/-</sup> (DKO) Cardiomyopathy
Authors: Alfredo Mijares, Juan Kolster, Jose A Adams, Jose R Lopez
Journal: Circulation (2015)

Duchenne Muscular Dystrophy cardiomyopathy (DMDC) is a progressive lethal disease. The dystrophin and utrophin double knock-out ( DKO ) mice ( dystrophin –/– /utrophin –/– ) share histopathological markers with DMDC. DKO is a very severe model of DMDC. pGz is the sinusoidal head to foot motion of the body, inducing pulsatile shear stress to the vascular endothelium activating endothelial nitric oxide synthase (eNOS) to produce small quantities of cardiac eNO. eNO has been shown to reduce ROS production, modulate intracellular Ca 2+ and Na + concentrations and inhibit calpain mediated proteolysis. We previously showed that pGz decreases diastolic Ca 2+ and Na + overload in cardiomyocytes from mdx mice, and confers cardioprotection. Hypothesis: We tested the hypothesis that pGz may also confer cardioprotection in the most severe form of DMDC, the DKO. Methods: DKO mice were randomized at 3-mo of age to daily pGz (ƒ=480 cpm,Gz ± 3.0 mt/sec 2 ,1hr/day for 2 weeks) (DKO+pGz) or none (DKO), a separate age matched non-diseased group of wt (CONT) and CONT treated with pGz (CONT+pGz). Cardiomyocytes where isolated from each group and intracellular diastolic Ca 2+ ([Ca 2+ ] d ) and Na + ([Na + ] d ) measured with microelectrodes. Calpain activity (Calpain-Glo), ROS production (DCFH-DA), were also measured. Results: DKO mice had a 5X and 4X fold(X) elevation in [Ca 2+ ] d and [Na + ] d, respectively compared to CONT . pGz significantly reduced this elevation. Calpain activity was significantly increased (3X) in DKO compared to CONT and it was reduced by pGz. ROS production which was increased in DKO (3X) was blunted by pGz. pGz did not affect [Ca 2+ ] d, [Na + ] d , Calpain activity or ROS production in CONT. [(Figure, M±SD )***p&lt; 0.001] Conclusion: pGz markedly improves intracellular Ca 2+ and Na + as well as decreasing Calpain and ROS production in DKO cardiomyocytes. These finding suggest that pGz has therapeutic potential as a novel therapeutic intervention in DMD cardiomyopathy.
Prophylactic Resuscitative Endovascular Occlusion of the Aorta (REBOA) for Morbidly Adherent Placenta and Hysterectomy; a Tertiary Care Center’s Experience
Authors: S. Siskind, D. Thompson, T. Migdal, N. Hoffman, S. Pachtman, A. Fleischer, M. Bank, I. Botwinick, R. Dela Cruz, V. Patel, G. Coppa, P. Wang, M. Giangola
Journal: International Journal of Surgery (2020)
Survey of Teen Noise Exposure and Efforts to Protect Hearing at School — United States, 2020
Authors: John Eichwald, Franco Scinicariello
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

Noise-induced hearing loss (NIHL) is a substantial, often unrecognized, health problem. Various learning environments and activities in school settings are loud. Researchers have reported the prevalence of NIHL among U.S. adolescents ranging between 12.8% and 17.5%, suggesting that one in every six to eight middle and high school students (aged 12-19 years) has measurable hearing loss likely resulting from excessive noise exposure (1). Evidence suggests that even mild levels of hearing loss negatively affect auditory perception and cognitive skills.* CDC analyzed data from a sample of 817 youths aged 12-17 years who responded to the web-based YouthStyles survey in 2020. The survey measured the frequency of exposure to loud noise in school settings, the provision of hearing protection devices (HPDs) during exposure, and whether prevention techniques were part of their educational curriculum. Approximately three in four teenage students reported being exposed to loud sound at school, and nearly one half (46.5%) of respondents reported exposure to loud sounds at school on a regular basis. A majority of students (85.9%) reported that their school did not provide HPDs during classes or activities where they were exposed to loud sounds, and seven out of 10 reported they were never taught how to protect their hearing. Increasing youth's awareness about the adverse health effects of excessive noise exposure and simple preventive measures to reduce risk can help prevent or reduce NIHL. Health care providers and educators have resources and tools available to prevent NIHL among school-aged children. Increased efforts are needed to promote prevention.
13035 Multiple carotenoids supplementation enhances human skin protection against ultraviolet A–induced skin pigmentation: A randomized, double-blind, placebo-controlled clinical trial
Authors: Sudhir M. Baswan, Alessandra Marini, Allison E. Klosner, Thomas Jaenicke Dr, Jesse Leverett, Mary Murray, Kevin W. Gellenbeck, Jean Krutmann
Journal: Journal of the American Academy of Dermatology (2020)
Prevalence and Trends in Cigarette Smoking Among Adults with Epilepsy — United States, 2010–2017
Authors: Sanjeeb Sapkota, Rosemarie Kobau, Janet B. Croft, Brian A. King, Craig Thomas, Matthew M. Zack
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

Cigarette smoking remains the leading cause of preventable disease and death in the United States (1).Although the percentage of all U.S. adults who smoke cigarettes has declined substantially since the mid-1960s (1,2), marked disparities persist, and declines have not been consistent across population groups (1,2).Studies have shown that cigarette smoking is as common, and sometimes more so, among adults with a history of epilepsy compared with those without a history of epilepsy, but reasons for this are unclear (3-6).Compared with adults without epilepsy, adults with epilepsy report lower household income, more unemployment and disability, worse psychological health, and reduced health-related quality of life (3,4,6,7).Trends in cigarette smoking among U.S. adults with epilepsy have not been previously assessed.CDC analyzed National Health Interview Survey (NHIS) data among 121,497 U.S. adults from 2010, 2013, 2015, and 2017 to assess current cigarette smoking by epilepsy status.From 2010 through 2017, the age-standardized percentages of current smoking were 24.9% among adults with active epilepsy, 25.9% among adults with inactive epilepsy, and 16.6% among adults with no history of epilepsy.After accounting for differences in data collection intervals and patterns in smoking status among subgroups, CDC found that current cigarette smoking declined significantly from 2010 to 2017 among adults with no history of epilepsy (19.3% to 14.0% [p<0.001]) and inactive epilepsy (29.2% to 16.2% [p = 0.03]), but declines among adults with active epilepsy were not statistically significant (26.4% to 21.8% [p = 0.2]).Epilepsy health and social service providers should promote smoking cessation resources to adults with active epilepsy who smoke cigarettes to help them quit smoking and to reduce their risk of smoking-related disease and death.*NHIS is an annual, nationally representative, in-person survey of the noninstitutionalized U.S. civilian population.The NHIS Sample Adult core questionnaire is administered to a randomly selected adult aged ≥18 years in each family within the selected household.Sample sizes and final response rates for sample adults in each of the 4 years were as follows: 2010 (27,157; 72
Abstract 16319: Comparison of In-Stent Responses Between Durable Polymer and Bioabsorbable Polymer Everolimus-Eluting Stent in a Human-Like Coronary Atherosclerotic Porcine Model
Authors: Daisuke Kitano, Yuxin Li, Suguru Migita, Hiroyuki Hao, Atsushi Hirayama, Yasuo Okumura
Journal: Circulation (2019)

Introduction: Clinical trials reported that there were no significant differences in 12-month outcome between durable polymer everolimus-eluting stent (DP-EES) and bioabsorbable polymer everolimus-...
Abstract 16909: Anonymity Brings Out the Truth in Social Behavior in Heart Transplantation
Authors: Sadia Dimbil, Angela Velleca, Michelle Kittleson, Jignesh Patel, Ryan Levine, Elizabeth Passano, Jon A Kobashigawa
Journal: Circulation (2018)

Introduction: In our heart transplant program, drugs (marijuana) alcohol and smoking are not allowed. Recidivism for drugs, alcohol, and smoking in heart transplant patients is not firmly established as many reported surveys are not anonymous. Anonymity allows patients to freely admit indulgence in these frowned upon activities. We performed an anonymous survey for patients greater than 1 year after transplant to assess their actual use of drugs, alcohol, and smoking. Methods: Between December 2016 and May 2018, we administered surveys to 104 patients more than 1-year post transplant. Patients directly entered their answers into a handheld computer so as to maintain anonymity. The survey included questions on use of drugs (marijuana), alcohol and smoking; and whether they quit within 6 months prior to transplant. Other questions included activity/quantity of use after transplant. Results: Of 24/104 patients who smoked prior to surgery, only 2 returned to smoking and 1 started smoking after heart transplant. For alcohol use, 48/104 had a history of drinking alcohol prior to transplant. 59/104 patients stated that they drank alcohol after transplant, averaging only 0-3 drinks per week, and usually beginning after 6 months post-transplant. In terms of marijuana, 8/104 smoked prior to heart transplant. Post-transplant, 12 patients used marijuana, mostly due to pain relief and recreation. Most patients (83.3%) began to use marijuana beginning 12 months post-transplant. Conclusion: In an anonymous survey of heart transplant patients more than 1-year post-transplant, initiation and recidivism to smoking and marijuana is low with renewal of social drinking post-transplant being common. This survey reveals real-life social activities of heart transplant patients.
Ischemic Versus Nonischemic Chest Pain in the Emergency Room: Echoes of Contrast**Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Authors: Mani A. Vannan, Jagat Narula
Journal: Journal of the American College of Cardiology (2005)
Racial Differences in Population Attributable Risk for Epithelial Ovarian Cancer in the OCWAA Consortium
Authors: Lauren C Peres, Traci N Bethea, Tareq F Camacho, Elisa V Bandera, Alicia Beeghly-Fadiel, Deanna L Chyn, Holly R Harris, Charlotte E Joslin, Patricia G Moorman, Evan Myers, Heather M Ochs-Balcom, Will Rosenow, V Wendy Setiawan, Anna H Wu, Lynn Rosenberg, Joellen M Schildkraut
Journal: JNCI Journal of the National Cancer Institute (2020)

The causes of racial disparities in epithelial ovarian cancer (EOC) incidence remain unclear. Differences in the prevalence of ovarian cancer risk factors may explain disparities in EOC incidence among African American (AA) and White women.We used data from 4 case-control studies and 3 case-control studies nested within prospective cohorts in the Ovarian Cancer in Women of African Ancestry Consortium to estimate race-specific associations of 10 known or suspected EOC risk factors using logistic regression. Using the Bruzzi method, race-specific population attributable risks (PAR) were estimated for each risk factor individually and collectively, including groupings of exposures (reproductive factors and modifiable factors). All statistical tests were 2-sided.Among 3244 White EOC cases and 9638 controls and 1052 AA EOC cases and 2410 controls, AA women had a statistically significantly higher PAR (false discovery rate [FDR] P < .001) for first-degree family history of breast cancer (PAR = 10.1%, 95% confidence interval [CI] = 6.5% to 13.7%) compared with White women (PAR = 2.6%, 95% CI = 0.8% to 4.4%). After multiple test correction, AA women had a higher PAR than White women when evaluating all risk factors collectively (PAR = 61.6%, 95% CI = 48.6% to 71.3% vs PAR = 43.0%, 95% CI = 32.8% to 51.4%, respectively; FDR P = .06) and for modifiable exposures, including body mass index, oral contraceptives, aspirin, and body powder (PAR = 36.0%, 95% CI = 21.0% to 48.8% vs PAR = 13.8%, 95% CI = 4.5% to 21.8%, respectively; FDR P = .04).Collectively, the selected risk factors accounted for slightly more of the risk among AA than White women, and interventions to reduce EOC incidence that are focused on multiple modifiable risk factors may be slightly more beneficial to AA women than White women at risk for EOC.
37P Correlation between haematological toxicity with quality of life in breast cancer patients after first-cycle chemotherapy
Authors: F. Wijovi, A. Kurniawan, B.A. Baskoro, H. Putri, A. Tancherla, F. Dharmaraja, O.J.D.A. Saroso, W.M. Rafaello, J. Fahman, C. Cindy, M. Claudia
Journal: Annals of Oncology (2020)
ギニアにおける母子保健サービスへのエボラウイルス疾患の影響:後向き観察的コホート研究【Powered by NICT】
Authors: Delamou Alexandre, Ayadi Alison M El, Sidibe Sidikiba, Delvaux Therese, Camara Bienvenu S, Sandouno Sah D, Beavogui Abdoul H, Rutherford Georges W, Okumura Junko, Zhang Wei-Hong, De Brouwere Vincent
Journal: The Lancet Global Health (2017)
257O Intercontinental cooperative non-Hodgkin T-cell lymphoma prospective registry study in Asia: ICT study
Authors: S.E. Yoon, S.J. Kim, D.H. Yoon, T-Y. Chen, Y. Koh, K.W. Kang, H.S. Lee, K. Kuang Wei Tay, S.T. Lim, M. Poon, C. Irawan, W. Zhao, Y.R. Do, M.H. Lee, S.C. Ng, W-S. Lee, Y. Guo, H. Zhang, J. Zhu, W.S. Kim
Journal: Annals of Oncology (2020)
Favorable response to immunotherapy in a pancreatic neuroendocrine tumor with temozolomide‐induced high tumor mutational burden
Authors: Yanshuo Cao, Yutong Ma, Jiangyuan Yu, Yu Sun, Tingting Sun, Yang Shao, Jie Li, Lin Shen, Ming Lu
Journal: Cancer Communications (2020)

Abstract Neuroendocrine neoplasm of the pancreas is a rare tumor with limited treatment options. Among such tumors, treatment for pancreatic neuroendocrine tumor (PanNET) G3 is the most difficult. Temozolomide (TMZ) is commonly used to treat PanNET. However, TMZ may cause tumor gene alkylation, which induces drug resistance and rapid disease progression. Herein, we present a case of a female who was diagnosed with PanNET G3 and achieved a partial response to toripalimab, an anti‐programmed cell death‐ligand 1 (anti‐PD‐L1) monoclonal antibody, after multiple cycles of TMZ treatment. Genomic profiling revealed that compared with the patient's samples collected at baseline, the post‐TMZ‐treatment samples had markedly higher levels of tumor mutational burden (TMB) associated with characteristic alkylating mutational signature representing a positive correlation with favorable response to anti‐PD‐1 treatment. In addition, we observed a germline truncating mutation of MUTYH (W156*) that was considered to be pathogenic and potentially conferred to genomic instability. This case suggests that anti‐PD‐1 therapy could be a treatment option for PanNET patients with increased TMB after TMZ‐based treatment.
SARS-CoV-2 (COVID-19) superspreader events
Authors: Dasha Majra, Jayme Benson, Jennifer Pitts, Justin Stebbing
Journal: Journal of Infection (2020)

A significant number of reported COVID-19 cases can be traced back to superspreader events (SSEs), where a disproportionally large number of secondary cases relative to the standard reproductive rate, R0, are initiated. Although a superspreader is an individual who undergoes more viral shedding and transmission than others, it appears likely that environmental factors have a substantial role in SSEs. We categorise SSEs into two distinct groups: 'societal' and 'isolated' SSEs.
Myocardial Infarction in the ISCHEMIA Trial
Authors: Bernard R. Chaitman, Karen P. Alexander, Derek D. Cyr, Jeffrey S. Berger, Harmony R. Reynolds, Sripal Bangalore, William E. Boden, Renato D. Lopes, Marcin Demkow, Gian Piero Perna, Robert K. Riezebos, Edward O. McFalls, Subhash Banerjee, Akshay Bagai, Gilbert Gosselin, Sean M. O’Brien, Frank W. Rockhold, David D. Waters, Kristian A. Thygesen, Gregg W. Stone, Harvey D. White, David J. Maron, Judith S. Hochman
Journal: Circulation (2020)

Background: In the ISCHEMIA trial (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches), an initial invasive strategy did not significantly reduce rates of cardiovascular events or all-cause mortality in comparison with a conservative strategy in patients with stable ischemic heart disease and moderate/severe myocardial ischemia. The most frequent component of composite cardiovascular end points was myocardial infarction (MI). Methods: ISCHEMIA prespecified that the primary and major secondary composite end points of the trial be analyzed using 2 MI definitions. For procedural MI, the primary MI definition used creatine kinase-MB as the preferred biomarker, whereas the secondary definition used cardiac troponin. Procedural thresholds were &gt;5 times the upper reference level for percutaneous coronary intervention and &gt;10 times for coronary artery bypass grafting. Procedural MI definitions included (1) a category of elevated biomarker only events with much higher biomarker thresholds, (2) new ST-segment depression of ≥1 mm for the primary and ≥0.5 mm for the secondary definition, and (3) new coronary dissections &gt; National Heart, Lung, and Blood Institute grade 3. We compared MI type, frequency, and prognosis by treatment assignment using both MI definitions. Results: Procedural MIs accounted for 20.1% of all MI events with the primary definition and 40.6% of all MI events with the secondary definition. Four-year MI rates in patients undergoing revascularization were more frequent with the invasive versus conservative strategy using the primary (2.7% versus 1.1%; adjusted hazard ratio [HR], 2.98 [95% CI, 1.87–4.73]) and secondary (8.2% versus 2.0%; adjusted HR, 5.04 [95% CI, 3.64–6.97]) MI definitions. Type 1 MIs were less frequent with the invasive versus conservative strategy using the primary (3.40% versus 6.89%; adjusted HR, 0.53 [95% CI, 0.41–0.69]; P &lt;0.0001) and secondary (3.48% versus 6.89%; adjusted HR, 0.53 [95% CI, 0.41–0.69]; P &lt;0.0001) definitions. The risk of subsequent cardiovascular death was higher after a type 1 MI than after no MI using the primary (adjusted HR, 3.38 [95% CI, 2.03–5.61]; P &lt;0.001) or secondary MI definition (adjusted HR, 3.52 [2.11–5.88]; P &lt;0.001). Conclusions: In ISCHEMIA, type 1 MI events using the primary and secondary definitions during 5-year follow-up were more frequent with an initial conservative strategy and associated with subsequent cardiovascular death. Procedural MI rates were greater in the invasive strategy and with the use of the secondary MI definition. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01471522.
400P Sequential afatinib and osimertinib in real-world EGFR mutation positive (EGFRm+) NSCLC: Final analysis of Asian patients in the GioTag study
Authors: M.J. Hochmair, A. Morabito, D. Hao, C-T. Yang, R.A. Soo, J.C-H. Yang, R. Gucalp, B. Halmos, A. Märten, T. Cufer
Journal: Annals of Oncology (2020)