tbuckley/cabot-search huggingface dataset:
Non-alcoholic fatty liver disease increases risk of carotid atherosclerosis and ischemic stroke: An updated meta-analysis with 135,602 individuals
Authors: Ansel Shao Pin Tang, Kai En Chan, Jingxuan Quek, Jieling Xiao, Phoebe Tay, Margaret Teng, Keng Siang Lee, Snow Yunni Lin, May Zin Myint, Benjamin Tan, Vijay K Sharma, Darren Jun Hao Tan, Wen Hui Lim, Apichat Kaewdech, Daniel Huang, Nicholas WS Chew, Mohammad Shadab Siddiqui, Arun J Sanyal, Mark Muthiah, Cheng Han Ng
Journal: Clinical and Molecular Hepatology (2022)

Non-alcoholic fatty liver disease (NAFLD) is associated with the development of cardiovascular disease. While existing studies have examined cardiac remodeling in NAFLD, there has been less emphasis on the development of carotid atherosclerosis and stroke. We sought to conduct a meta-analysis to quantify the prevalence, risk factors, and degree of risk increment of carotid atherosclerosis and stroke in NAFLD.Embase and Medline were searched for articles relating to NAFLD, carotid atherosclerosis, and stroke. Proportional data was analysed using a generalized linear mixed model. Pairwise meta-analysis was conducted to obtain odds ratio or weighted mean difference for comparison between patients with and without NAFLD.From pooled analysis of 30 studies involving 7,951 patients with NAFLD, 35.02% (95% confidence interval [CI], 27.36-43.53%) had carotid atherosclerosis with an odds ratio of 3.20 (95% CI, 2.37-4.32; P<0.0001). Pooled analysis of 25,839 patients with NAFLD found the prevalence of stroke to be 5.04% (95% CI, 2.74-9.09%) with an odds ratio of 1.88 (95% CI, 1.23-2.88; P=0.02) compared to non-NAFLD. The degree of steatosis assessed by ultrasonography in NAFLD was closely associated with risk of carotid atherosclerosis and stroke. Older age significantly increased the risk of developing carotid atherosclerosis, but not stroke in NAFLD.This meta-analysis shows that a stepwise increment of steatosis of NAFLD can significantly increase the risk of carotid atherosclerosis and stroke development in NAFLD. Patients more than a third sufferred from carotid atherosclerosis and routine assessment of carotid atherosclerosis is quintessential in NAFLD.
PNEUMOCOCCAL POLYARTHRITIS
Authors: A. S. Gubb
Journal: BMJ (1924)

V'Anious views have been put forward as to the cause of the morning vomitinog of pregnanicy, which occur's from the sixth to the fourteenith week, and is more common in primigravidae than in multipaiae.It usually occurs in the eai-ly mnorning, anid wlhero tlhe conidition becomes aggra- vated it occurs thlroughout tlhe day.In the severest cases it miiay become almost continuous.The view-s that have been held inlclude as causes toxaemia, I,ivsteria, an-id a ieflex type.The view that it is due to a deficiency of glycogeni in the maternal liver was put forward by Duncan anid Haiding in 1918, and the case given below -as treated in accordaince with it.Mrs. H., aged 27, eight weeks pregnant, was admitted to the Hull Royal Infirmary on November 4th, 1923.Her last period had been on Septemnber 7th.She had been vomiting for three w-eeks, first after bieakfast, then after every meal, then all day, and lat-terly all niight, at short intervals.On the date mentioned she lhad been vomiting every half-hour.The vomit was green, con- tained mucus, and some specimens digested blood also.The pulse was 88, temperature 99.80; heart and lbangs normal, abdomen lrather retracted; niothing abnormal was felt.The tongue was clean.Oni vaainal examination the os uteri wvas found soft and enlarged, ecesistent witlh two months' pregnancy.Urine: specific gravity 1030, acid, no albumin, no blood, no pus, no bile, no diacetic acid or acetone present.The blood was examined by Dr.Adamson, honorary pathologist, for the blood sugar content, which was found to be normal (0.095).The patient was very exhausted and was suiffering from lack of sleep, not having slept for two or three nights owing to the almost continuous vomiting.Treatment was started at 3 p.m. on November 4th by gastric lavage with sodium bicarbonate solution (1 draclim to the pint), one or two pints being used.Rectal salines, with half an ounce each of sodium bicarbonate and glucose to the pint, were adminis- tered, 1 pint every four hours.Solution of adrenaline, 5 minims lhypodermically, was ordered every three hours for four doses or
Letter: Consultant contract.
Authors: D Gibbons, M Phillips, D Sumner, J Kalk, B Whiting, A Bartholomay, In Physicomathematical, Yournal Garrett, A Adam, Peter Jones, Peter Brunnen, Robert Main, P Brunt, Norman Matheson, L Davidson, W Michie, Allan Downie, R Milne, W Emslie, Ashley Mowat, N Fraser, C Needham, W Gauld, Alec Rennie, F Sambrook Gowar, David Short, N Hendry, J Wyper, J Hern
Journal: BMJ (1975)

Acute Calf Swelling SIR,-Dr.B. Thalayasingam and others (21 December, p. 719) point out that acute synovial rupture of the knee joint may cause an acute swelling of the calf which closely mimics deep vein thrombosis.They add that this condition is underdiagnosed and blame in part its poor documentation in the general medical literature.However, there may be a further reason for its underdiagnosis.We have recently described a patient who presented with an acute swelling of the calf.'This was diagnosed as due to a deep vein thrombosis and the diagnosis was apparently confirmed by the elevated uptake of '5I-radiofibrinogen measured over the affected area.During treatment with heparin he developed a haematoma of the calf, and the true diagnosis of ruptured synovium of the knee joint was then established by arthrography.The false positive result of the radiofibrinogen test was probably due to the radioactive material in blood and synovial fluid trucking down into the muscles of the calf.125I-radiofibrinogen uptake is an estab- lished test for deep vein thrombosis.2If such false positive results were common, this would contribute to the widespread underdiagnosis of acute synovial rupture of the knee joint.-Weare, etc.,
Suppressing fatty acid synthase by type I interferon and chemical inhibitors as a broad spectrum anti-viral strategy against SARS-CoV-2
Authors: Saba R. Aliyari, Amir Ali Ghaffari, Olivier Pernet, Kislay Parvatiyar, Yao Wang, Hoda Gerami, Ann-Jay Tong, Laurent Vergnes, Armin Takallou, Adel Zhang, Xiaochao Wei, Linda D. Chilin, Yuntao Wu, Clay F. Semenkovich, Karen Reue, Stephen T. Smale, Benhur Lee, Genhong Cheng
Journal: Acta Pharmaceutica Sinica B (2022)

SARS-CoV-2 is an emerging viral pathogen and a major global public health challenge since December of 2019, with limited effective treatments throughout the pandemic. As part of the innate immune response to viral infection, type I interferons (IFN-I) trigger a signaling cascade that culminates in the activation of hundreds of genes, known as interferon stimulated genes (ISGs), that collectively foster an antiviral state. We report here the identification of a group of type I interferon suppressed genes, including fatty acid synthase (FASN), which are involved in lipid metabolism. Overexpression of FASN or the addition of its downstream product, palmitate, increased viral infection while knockout or knockdown of FASN reduced infection. More importantly, pharmacological inhibitors of FASN effectively blocked infections with a broad range of viruses, including SARS-CoV-2 and its variants of concern. Thus, our studies not only suggest that downregulation of metabolic genes may present an antiviral strategy by type I interferon, but they also introduce the potential for FASN inhibitors to have a therapeutic application in combating emerging infectious diseases such as COVID-19.
PARACELSUS AFTER FOUR HUNDRED YEARS
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lectures on Certain Diseases of the Jaws
Authors: C. Heath
Journal: BMJ (1887)

Cysts in conaection with undeveloped teeth, or De,,ntigerous Cysts (coronary cysts of Magitot), may occur in either jaw.These, as already mentioned, may suppurate and give rise to abscess, which mav be confounded with suppuration within the antrum, or may project into the antrum, filling the cavity or communicating with it.Dentigerous cysts arise in connection with teeth which from some cause have remained within the jaw, and have undergone a certain amount of irritation.They are almost invariably connected with permanent teeth, thongh Mr. Salter mentions a case in connection with a temporary molar occurring in the practice of Mr. Alexander Edwards, late of Edinburgh; and in a remarkable specimen belonging to Mr. Cartwright, which will be afterwards referred to, the tooth is a supernumerary one.I have also myself met with an example of cyst coDnected with a temporary tooth in a boy aged 4, brought to me by Mr. 0. J. Fox.In this case the temporary right canine tooth was wanting, and there was a cyst developed in its situation, on cutting into which I extracted seven small irregular nodules of dentine and enamel, but no complete tooth, this being, therefore, an example of the odonto-plastic cyst of Magitot.Mr. Tomes explains the tormation of cysts in connection with retained teeth by referring to the fact that, when the development of the enamel of a tooth is completed, its outer surface becomes perfectly detached from the investing soft tissue, and a small quantity.oftrans- parent fluiid not uncommonly collects in the interval so formed.This fluid ordinarily is discharged when the tooth is cut; but when from some cause the eruption of the tooth is prevented, it increases in quantity, gradually distending the surrounding tissues in the form of a cyst.
Age-dependent effects of <i>Igf2bp2</i> on gene regulation, function, and aging of hematopoietic stem cells in mice
Authors: Miaomiao Suo, Megan K. Rommelfanger, Yulin Chen, Elias Moris Amro, Bing Han, Zhiyang Chen, Karol Szafranski, Sundaram Reddy Chakkarappan, Bernhard O. Boehm, Adam L. MacLean, K. Lenhard Rudolph
Journal: Blood (2022)

Abstract Increasing evidence links metabolism, protein synthesis, and growth signaling to impairments in the function of hematopoietic stem and progenitor cells (HSPCs) during aging. The Lin28b/Hmga2 pathway controls tissue development, and the postnatal downregulation of this pathway limits the self-renewal of adult vs fetal hematopoietic stem cells (HSCs). Igf2bp2 is an RNA binding protein downstream of Lin28b/Hmga2, which regulates messenger RNA stability and translation. The role of Igf2bp2 in HSC aging is unknown. In this study, an analysis of wild-type and Igf2bp2 knockout mice showed that Igf2bp2 regulates oxidative metabolism in HSPCs and the expression of metabolism, protein synthesis, and stemness-related genes in HSCs of young mice. Interestingly, Igf2bp2 expression and function strongly declined in aging HSCs. In young mice, Igf2bp2 deletion mimicked aging-related changes in HSCs, including changes in Igf2bp2 target gene expression and impairment of colony formation and repopulation capacity. In aged mice, Igf2bp2 gene status had no effect on these parameters in HSCs. Unexpectedly, Igf2bp2-deficient mice exhibited an amelioration of the aging-associated increase in HSCs and myeloid-skewed differentiation. The results suggest that Igf2bp2 controls mitochondrial metabolism, protein synthesis, growth, and stemness of young HSCs, which is necessary for full HSC function during young adult age. However, Igf2bp2 gene function is lost during aging, and it appears to contribute to HSC aging in 2 ways: the aging-related loss of Igf2bp2 gene function impairs the growth and repopulation capacity of aging HSCs, and the activity of Igf2bp2 at a young age contributes to aging-associated HSC expansion and myeloid skewing.
P1-106: Evaluation of SV-40 as a biological prognostic factor in Egyptian patients with malignant pleural mesothelioma
Authors: Abeer A. Bahnassy, Rabab M. Gaafar, Abdel-Rahman N. Zekri, Nelly A. Hassan, Fatma Aboulkassem, Mohamed Abdel-Rahman, Waleed S. Mohammad
Journal: Journal of Thoracic Oncology (2007)
Erratum. COVID-19 Severity Is Tripled in the Diabetes Community: A Prospective Analysis of the Pandemic’s Impact in Type 1 and Type 2 Diabetes. Diabetes Care 2021;44:526–532
Authors: Justin M. Gregory, James C. Slaughter, Sara H. Duffus, T. Jordan Smith, Lauren M. LeStourgeon, Sarah S. Jaser, Allison B. McCoy, James M. Luther, Erin R. Giovannetti, Schafer Boeder, Jeremy H. Pettus, Daniel J. Moore
Journal: Diabetes Care (2022)
FIBROSCAN IN ASSOCIATION WITH FIB-4, APRI, AND AST/ALT RATIO FOR ASSESSMENT OF LIVER FIBROSIS IN NON ALCOHOLIC FATTY LIVER DISEASE IN WOMEN WITH T2DM
Authors: Dakshata Padhye, Snehal Tanna, Ms Aleyamma James, Ms Nithya Nair, Ms Muskan Shah, Ms Reva Kovil
Journal: Metabolism (2022)
COUNCIL ON MEDICAL EDUCATION AND HOSPITALS
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Has the covid pandemic changed the debate about nationalising GPs?
Authors: Azeem Majeed, Simon Hodes
Journal: BMJ (2022)

The pandemic has led the UK health secretary into a debate on whether GPs should be directly employed by the NHS. <b>Azeem Majeed</b> argues that this is an opportunity to correct a flawed model, but <b>Simon Hodes</b> says that partnerships are still the best model for primary care
VACCINATION DURING ERUPTIVE STAGE OF SMALLPOX.
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Air pollution susceptibility in children with asthma and obesity: tidal volume as key player?
Authors: Judith M. Vonk, Jolt Roukema
Journal: European Respiratory Journal (2022)

<b>The higher susceptibility to air pollution of asthmatic children with a higher BMI can (partly) be explained by differences in breathing patterns that result in a higher (alveolar) lung deposition of PM<sub>2.5</sub></b>https://bit.ly/3FuNpxM
Secretary of County Society.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum. Effects of the SGLT2 Inhibitor Dapagliflozin on Energy Metabolism in Patients With Type 2 Diabetes: A Randomized, Double-Blind Crossover Trial. Diabetes Care 2021;44:1334–1343
Authors: Yvo J.M. Op den Kamp, Marlies de Ligt, Bas Dautzenberg, Esther Kornips, Russell Esterline, Matthijs K.C. Hesselink, Joris Hoeks, Vera B. Schrauwen-Hinderling, Bas Havekes, Jan Oscarsson, Esther Phielix, Patrick Schrauwen
Journal: Diabetes Care (2022)
Value of biopsy and brush cytology in the diagnosis of gastric cancer. Shanghai Gastrointestinal Endoscopy Cooperative Group, People's Republic of China.
Journal: Gut (1982)

Abstract This report presents the diagnostic value of brush cytology in gastric cancer. Gastric biopsies and brush cytology were performed in 155 patients with gastric cancer and 48 with benign gastric disease. The positive rate for biopsy and brush cytology in cancer patients (including 11 cases of early gastric cancer) was 74.2% and 76.8% respectively. The positive rate of biopsy with concomitant brush cytology was 87.7, which was superior to that of biopsy or brush cytology alone (p less than 0.01). In 29 cases of gastric cancer involving the cardiac region. 20 were biopsy positive (69%) and 22 were brush cytology positive (75.9%). Biopsy with brush cytology was positive in 27 cases (93.1%) and gave better results than biopsy alone (p less than 0.01). The positive rate of biopsy with concomitant brush cytology in Borrmann type I, II, and III lesions (89.7%) was significantly higher than in Borrmann type IV lesions (50%). In the 48 patients with benign gastric lesion, biopsy and brush cytology each provided two false positives. The study shows that the combination of biopsy and brush cytology increases diagnostic accuracy for gastric cancer.
RNA profiling of blood platelets noninvasively differentiates colorectal cancer from healthy donors and noncancerous intestinal diseases: a retrospective cohort study
Authors: Luming Xu, Xinbo Li, Xiangchun Li, Xingyue Wang, Qian Ma, Dan She, Xiaohuan Lu, Jiao Zhang, Qianqian Yang, Shijun Lei, Lin Wang, Zheng Wang
Journal: Genome Medicine (2022)

The RNA profiles of tumor-educated platelets (TEPs) possess pathological features that could be used for early cancer detection. However, the utility of TEP RNA profiling in detecting early colorectal cancer (CRC) versus noncancerous colorectal diseases has not yet been investigated. This study assesses the diagnostic capacity of TEP RNA profiles in a cohort of patients with CRC and noncancerous diseases.Transcriptome sequencing for platelets isolated from 132 patients with CRC at early and late stages and 190 controls consisting of healthy donors and patients with ulcerative disease, Crohn's disease, polyps, and adenomas was performed and analyzed using binary particle swarm optimization coupled with support vector machine to identify genes that contributed to the classification of CRC patients versus controls. The area under the receiver operating curves (AUROCs) and the accuracy of TEP RNA profiles in CRC diagnosis were assessed.TEP RNA profiling achieved high performance in distinguishing and staging CRC patients from the controls. Using the swarm intelligence algorithm, the 921 most contributive genes that classified CRC patients from the controls were identified. AUROCs of 0.928 for the training set via leave-one-out cross-validation and 0.92 for the validation set were achieved, both of which were significantly higher than the clinically utilized serum biomarkers: carcinoembryonic antigen and cancer antigen 19-9. Notably, an AUROC of 0.915 in an external validation set was achieved. For predicting different CRC stages, an AUROC of 0.984 was achieved in the training set and 1.000 in the internal validation set.RNA profiles of TEPs are of potential diagnostic value for identifying early CRC from noncancerous diseases. Prospective studies are needed to validate its clinical relevance.
Drug abuse in the United States. Strategies for prevention
Journal: JAMA (1991)

Efforts to curtail abuse of alcohol and other drugs concentrate on activities designed for supply-and-demand reduction. Many law enforcement and health officials agree that the reduction in supply of drugs cannot succeed as long as the demand for drugs for purposes of abuse occurs in a significant segment of society. Critical to reducing this demand is prevention. Only through an understanding of the correlates and risk factors associated with the use of alcohol and other drugs, along with the identification and implementation of sound strategies, can change occur. Although research has uncovered a considerable body of knowledge about the interplay of personal behavior, risk factors, and health in the prevention of substance abuse, many questions remain unanswered. Until those answers are known, efforts that have proven most effective need to be more widely emphasized.
Putting Genetics to Work in the Psychiatric Clinic
Authors: Francis J. McMahon
Journal: American Journal of Psychiatry (2022)

The rapid progress in psychiatric genetics over the past 10 years, while exciting from a research perspective, has not yet had an impact on clinical practice. How will we really be able to put genetics to work in the psychiatric clinic? This overview will attempt to answer this question. A survey of widely used methods and major study designs highlights key findings that have emerged so far. These findings inform a broad conceptual model of how genetic risk may act to influence dimensions of psychopathology and clinical presentations. The overview concludes with highlights of some of the most clinically relevant findings to date and their implications for psychiatric practice in the near future.