tbuckley/cabot-search huggingface dataset:
Selected Articles from This Issue
Journal: Clinical Cancer Research (2022)

Highlights| May 02 2022 Selected Articles from This Issue Author & Article Information Online ISSN: 1557-3265 Print ISSN: 1078-0432 ©2022 American Association for Cancer Research2022American Association for Cancer Research Clin Cancer Res (2022) 28 (9): 1743. https://doi.org/10.1158/1078-0432.CCR-28-9-HI Related Content A commentary has been published: Targeted Analysis of Cell-free Circulating Tumor DNA is Suitable for Early Relapse and Actionable Target Detection in Patients with Neuroblastoma A commentary has been published: Diminished Immune Surveillance during Histologic Progression of Intraductal Papillary Mucinous Neoplasms Offers a Therapeutic Opportunity for Cancer Interception A commentary has been published: Dose Escalation Data from the Phase 1 Study of the Liposomal Formulation of Eribulin (E7389-LF) in Japanese Patients with Advanced Solid Tumors View more This is a commentary to: Multiomic Analysis Reveals Comprehensive Tumor Heterogeneity and Distinct Immune Subtypes in Multifocal Intrahepatic Cholangiocarcinoma View less Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Article Versions Icon Versions Version of Record May 2 2022 Citation Selected Articles from This Issue. Clin Cancer Res 1 May 2022; 28 (9): 1743. https://doi.org/10.1158/1078-0432.CCR-28-9-HI Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search Encapsulation of anticancer medications within liposomes is a technique to facilitate drug transportation to the target and accumulation in tumors. Sato and colleagues evaluated the tolerability and efficacy of a liposomal formulation of eribulin (E7389-LF) in patients with advanced solid tumors. E7389-LF was well tolerated overall, and 4/21 of the patients treated achieved a partial response. Endothelial cell, vasculature, and immune-related biomarkers were increased after treatment. Thus E7389-LF may influence tumor vascular remodeling. These findings support further evaluation of E7389-LF for advanced solid tumors. Expansion cohorts are ongoing to evaluate the safety, efficacy, and pharmacodynamics of E7389-LF 2.0 mg/m2 every 3 weeks in specific tumor types. Molecular profiles in solid tumors dynamically evolve in response to endogenous and exogenous pressures. Lodrini and colleagues noninvasively monitored high-risk neuroblastoma evolution using droplet digital PCR assessing MYCN and ALK oncogene status in longitudinally collected biosamples to explore the clinical value of total... You do not currently have access to this content.
Electronic Health Interventions for Patients With Breast Cancer: Systematic Review and Meta-Analyses
Authors: Anna C. Singleton, Rebecca Raeside, Karice K. Hyun, Stephanie R. Partridge, Gian Luca Di Tanna, Nashid Hafiz, Qiang Tu, Justin Tat-Ko, Stephanie Che Mun Sum, Kerry A. Sherman, Elisabeth Elder, Julie Redfern
Journal: Journal of Clinical Oncology (2022)

PURPOSE Ongoing supportive care using electronic health (eHealth) interventions has the potential to provide remote support and improve health outcomes for patients with breast cancer. This study aimed to evaluate the effectiveness of eHealth interventions on patient-reported outcomes (quality of life [QOL], self-efficacy, and mental or physical health) for patients during and after breast cancer treatment and patient-reported experience measures (acceptability and engagement). METHODS Systematic review with meta-analyses (random-effects model) of randomized controlled trials was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Nine databases were searched using a prespecified search strategy. Patient-directed eHealth interventions for adult patients during or after active breast cancer treatment measuring QOL, self-efficacy, and mental (depressive, anxiety, and distress symptoms) or physical (physical activity, nutrition, and fatigue) health outcomes were included. Data from eligible full-text articles were independently extracted by six observers. RESULTS Thirty-two unique studies (4,790 patients) were included. All were health self-management interventions, and most were multicomponent (videos, forums, and electronic reminder systems) websites. Meta-analyses revealed a significant effect of eHealth interventions on QOL (standardized mean difference [SMD], 0.20 [95% CI, 0.03 to 0.36]), self-efficacy (SMD, 0.45 [95% CI, 0.24 to 0.65]), distress (SMD, –0.41 [95% CI,–0.63 to –0.20]), and fatigue (SMD, –0.37 [95% CI, –0.61 to –0.13]). Twenty-five studies (78.1%) measured patient-reported experience measures. Acceptability (n = 9) was high, with high ratings for satisfaction (range, 71%-100%), usefulness (range, 71%-95%), and ease-of-use (range, 73%-92%). Engagement (n = 25) decreased over time, but disease-focused information and interactive support were most engaging. CONCLUSION eHealth interventions may provide an acceptable and effective strategy for improving QOL, distress, self-efficacy, and fatigue among patients with breast cancer.
Early Changes in Billing and Notes After Evaluation and Management Guideline Change
Authors: Nate C. Apathy, Allison J. Hare, Sarah Fendrich, Dori A. Cross
Journal: Annals of Internal Medicine (2022)

The American Medical Association updated guidance in 2021 for frequently used billing codes for outpatient evaluation and management (E/M) visits. The intent was to account for provider time outside of face-to-face encounters and to reduce onerous documentation requirements.
Mortality Outcomes by Fibrosis Stage in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis
Authors: Cheng Han Ng, Wen Hui Lim, Grace En Hui Lim, Darren Jun Hao Tan, Nicholas Syn, Mark D. Muthiah, Daniel Q. Huang, Rohit Loomba
Journal: Clinical Gastroenterology and Hepatology (2022)
PHE Extends Telehealth Services—for Now
Journal: Cancer Discovery (2022)

The Public Health Emergency (PHE) declared by the U.S. Department of Health and Human Services in 2020 allowed coverage of telehealth-the use of electronic communication to deliver care remotely-by federal payers during the COVID-19 pandemic. However, the PHE could end in the coming months, so legislators have introduced bills in Congress to continue coverage for certain types of virtual visits under federal programs. Telehealth measures may be attached to the bill funding the federal government for fiscal year 2022, which could be enacted in mid-March.
Novel genetic variants associated with inhaled corticosteroid treatment response in older adults with asthma
Authors: Alberta L Wang, Lies Lahousse, Amber Dahlin, Ahmed Edris, Michael McGeachie, Sharon M Lutz, Joanne E Sordillo, Guy Brusselle, Jessica Lasky-Su, Scott T Weiss, Carlos Iribarren, Meng X Lu, Kelan G Tantisira, Ann C Wu
Journal: Thorax (2022)

Older adults have the greatest burden of asthma and poorest outcomes. The pharmacogenetics of inhaled corticosteroid (ICS) treatment response is not well studied in older adults.
Antigen-bearing outer membrane vesicles as tumour vaccines produced in situ by ingested genetically engineered bacteria
Authors: Yale Yue, Jiaqi Xu, Yao Li, Keman Cheng, Qingqing Feng, Xiaotu Ma, Nana Ma, Tianjiao Zhang, Xinwei Wang, Xiao Zhao, Guangjun Nie
Journal: Nature Biomedical Engineering (2022)
The future of targeted kinase inhibitors in melanoma
Authors: Signe Caksa, Usman Baqai, Andrew E. Aplin
Journal: Pharmacology & Therapeutics (2022)

Melanoma is a cancer of the pigment-producing cells of the body and its incidence is rising. Targeted inhibitors that act against kinases in the MAPK pathway are approved for BRAF-mutant metastatic cutaneous melanoma and increase patients' survival. Response to these therapies is limited by drug resistance and is less durable than with immune checkpoint inhibition. Conversely, rare melanoma subtypes have few therapeutic options for advanced disease and MAPK pathway targeting agents show minimal anti-tumor effects. Nevertheless, there is a future for targeted kinase inhibitors in melanoma: in new applications such as adjuvant or neoadjuvant therapy and in novel combinations with immunotherapies or other targeted therapies. Pre-clinical studies continue to identify tumor dependencies and their corresponding actionable drug targets, paving the way for rational targeted kinase inhibitor combinations as a personalized medicine approach for melanoma.
Dosing a synbiotic of human milk oligosaccharides and B. infantis leads to reversible engraftment in healthy adult microbiomes without antibiotics
Authors: Julie E. Button, Chloe A. Autran, Abigail L. Reens, Casey M. Cosetta, Steven Smriga, Megan Ericson, Jessica V. Pierce, David N. Cook, Martin L. Lee, Adam K. Sun, Amin M. Alousi, Andrew Y. Koh, David J. Rechtman, Robert R. Jenq, Gregory J. McKenzie
Journal: Cell Host & Microbe (2022)
Imaging response assessment for CNS germ cell tumours: consensus recommendations from the European Society for Paediatric Oncology Brain Tumour Group and North American Children's Oncology Group
Authors: Giovanni Morana, Dennis Shaw, Shannon M MacDonald, Claire Alapetite, Thankamma Ajithkumar, Aashim Bhatia, Hervé Brisse, Camilo Jaimes, Thomas Czech, Girish Dhall, Jason Fangusaro, Cecile Faure-Conter, Maryam Fouladi, Darren Hargrave, Julie H Harreld, Dipayan Mitra, James C Nicholson, Mark Souweidane, Beate Timmermann, Gabriele Calaminus, Ute Bartels, Brigitte Bison, Matthew J Murray
Journal: The Lancet Oncology (2022)
Rapid synthesis of ‘yolk-shell’-like nanosystem for MR molecular and chemo-radio sensitization
Authors: Meirong Hou, Kai Zhu, Honglei Hu, Shuting Zheng, Zede Wu, Yunyan Ren, Bin Wu, Li Qi, Dong Wu, Yikai Xu, Chenggong Yan, Bingxia Zhao
Journal: Journal of Controlled Release (2022)
Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis
Authors: Joseph N. Jarvis, David S. Lawrence, David B. Meya, Enock Kagimu, John Kasibante, Edward Mpoza, Morris K. Rutakingirwa, Kenneth Ssebambulidde, Lillian Tugume, Joshua Rhein, David R. Boulware, Henry C. Mwandumba, Melanie Moyo, Henry Mzinganjira, Cecilia Kanyama, Mina C. Hosseinipour, Chimwemwe Chawinga, Graeme Meintjes, Charlotte Schutz, Kyla Comins, Achita Singh, Conrad Muzoora, Samuel Jjunju, Edwin Nuwagira, Mosepele Mosepele, Tshepo Leeme, Keatlaretse Siamisang, Chiratidzo E. Ndhlovu, Admire Hlupeni, Constantine Mutata, Erik van Widenfelt, Tao Chen, Duolao Wang, William Hope, Timothée Boyer-Chammard, Angela Loyse, Síle F. Molloy, Nabila Youssouf, Olivier Lortholary, David G. Lalloo, Shabbar Jaffar, Thomas S. Harrison
Journal: New England Journal of Medicine (2022)

Cryptococcal meningitis is a leading cause of human immunodeficiency virus (HIV)-related death in sub-Saharan Africa. Whether a treatment regimen that includes a single high dose of liposomal amphotericin B would be efficacious is not known.
Prevalence of Short-Coupled Ventricular Fibrillation in a Large Cohort of Dutch Patients With Idiopathic Ventricular Fibrillation
Authors: Sanne A. Groeneveld, Martijn H. van der Ree, Bart A. Mulder, Jippe Balt, Arthur A.M. Wilde, Pieter G. Postema, Rutger J. Hassink
Journal: Circulation (2022)
Reversing the imbalance in bone homeostasis via sustained release of SIRT-1 agonist to promote bone healing under osteoporotic condition
Authors: Wei Zhang, Xingzhi Zhou, Weiduo Hou, Erman Chen, Chenyi Ye, Mo Chen, Qian Lu, Xiaohua Yu, Weixu Li
Journal: Bioactive Materials (2022)

The imbalance of bone homeostasis is the root cause of osteoporosis. However current therapeutic approaches mainly focus on either anabolic or catabolic pathways, which often fail to turn the imbalanced bone metabolism around. Herein we reported that a SIRT-1 agonist mediated molecular therapeutic strategy to reverse the imbalance in bone homeostasis by simultaneously regulating osteogenesis and osteoclastogenesis via locally sustained release of SRT2104 from mineral coated acellular matrix microparticles. Immobilization of SRT2104 on mineral coating (MAM/SRT) harnessing their electrostatic interactions resulted in sustained release of SIRT-1 agonist for over 30 days. MAM/SRT not only enhanced osteogenic differentiation and mineralization, but also attenuated the formation and function of excessive osteoclasts via integrating multiple vital upstream signals (β-catenin, FoxOs, Runx2, NFATc1, etc.) in vitro. Osteoporosis animal model also validated that it accelerated osteoporotic bone healing and improved osseointegration of the surrounding bone. Overall, our work proposes a promising strategy to treat osteoporotic bone defects by reversing the imbalance in bone homeostasis using designated small molecule drug delivery systems.
Converting Tumoral PD-L1 into a 4-1BB Agonist for Safer and More Effective Cancer Immunotherapy
Authors: Zihai Li, Joseph H. Azar, Mark P. Rubinstein
Journal: Cancer Discovery (2022)

Summary: Dose-limiting toxicities are thought to temper the efficacy of single-agent 4-1BB agonists. To overcome this hurdle, in this issue of Cancer Discovery, Muik and colleagues report preclinical and clinical studies describing a first-in-class bispecific fusion protein targeting 4-1BB and PD-L1. See related article by Muik et al., p. 1248 (9).
Modified chitosan for effective renal delivery of siRNA to treat acute kidney injury
Authors: Weimin Tang, Sudipta Panja, Chinmay M. Jogdeo, Siyuan Tang, Ling Ding, Ao Yu, Kirk W. Foster, Del L. Dsouza, Yashpal S. Chhonker, Heather Jensen-Smith, Hee-Seong Jang, Erika I. Boesen, Daryl J. Murry, Babu Padanilam, David Oupický
Journal: Biomaterials (2022)
A case of HBV-induced liver failure in the REEF-2 phase II trial: Implications for finite treatment strategies in HBV ‘cure’
Authors: Kosh Agarwal, James Lok, Ivana Carey, Yatin Shivkar, Michael Biermer, Thomas Berg, Isabelle Lonjon-Domanec
Journal: Journal of Hepatology (2022)

<h2>Summary</h2> Nucleoside analogues are the mainstay of treatment for patients with chronic HBV infection but have no direct effect on covalently closed circular DNA. Long-term HBV viral suppression is now routine, but the desirable endpoint of functional cure is rarely achieved. Newer therapies, targeting other aspects of the replicative life cycle of HBV, present opportunities to deliver finite therapy and HBV ‘cure'. This is an area of keen focus for the HBV community. We describe a severe case of hepatitis B reactivation, occurring shortly after the withdrawal of a nucleoside analogue within the protocol of a clinical trial (REEF-2). Despite best supportive care and prompt re-introduction of tenofovir, the patient developed subacute liver failure, requiring emergency orthotopic liver transplantation. As we strive to achieve HBV cure, this case highlights the potential risks of finite therapy and highlights the need for improved biomarker-driven strategies and re-evaluation of study protocols.
Diagnosis and Management of Acute Left-Sided Colonic Diverticulitis: A Clinical Guideline From the American College of Physicians
Authors: Amir Qaseem, Itziar Etxeandia-Ikobaltzeta, Jennifer S. Lin, Nick Fitterman, Tatyana Shamliyan, Timothy J. Wilt
Journal: Annals of Internal Medicine (2022)

Description: The American College of Physicians (ACP) developed this guideline to provide clinical recommendations on the diagnosis and management of acute left-sided colonic diverticulitis in adults. This guideline is based on current best available evidence about benefits and harms, taken in the context of costs and patient values and preferences. Methods: The ACP Clinical Guidelines Committee (CGC) developed this guideline based on a systematic review on the use of computed tomography (CT) for the diagnosis of acute left-sided colonic diverticulitis and on management via hospitalization, antibiotic use, and interventional percutaneous abscess drainage. The systematic review evaluated outcomes that the CGC rated as critical or important. This guideline was developed using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) methodology. Target Audience and Patient Population: The target audience is all clinicians, and the target patient population is adults with suspected or known acute left-sided colonic diverticulitis. Recommendation 1: ACP suggests that clinicians use abdominal CT imaging when there is diagnostic uncertainty in a patient with suspected acute left-sided colonic diverticulitis (conditional recommendation; low-certainty evidence). Recommendation 2: ACP suggests that clinicians manage most patients with acute uncomplicated left-sided colonic diverticulitis in an outpatient setting (conditional recommendation; low-certainty evidence). Recommendation 3: ACP suggests that clinicians initially manage select patients with acute uncomplicated left-sided colonic diverticulitis without antibiotics (conditional recommendation; low-certainty evidence).
A D2 to D1 shift in dopaminergic inputs to midbrain 5-HT neurons causes anorexia in mice
Authors: Xing Cai, Hailan Liu, Bing Feng, Meng Yu, Yang He, Hesong Liu, Chen Liang, Yongjie Yang, Longlong Tu, Nan Zhang, Lina Wang, Na Yin, Junying Han, Zili Yan, Chunmei Wang, Pingwen Xu, Qi Wu, Qingchun Tong, Yanlin He, Yong Xu
Journal: Nature Neuroscience (2022)
Maternal Phthalate and Bisphenol Urine Concentrations during Pregnancy and Early Markers of Arterial Health in Children
Authors: Sophia M. Blaauwendraad, Romy Gaillard, Susana Santos, Chalana M. Sol, Kurunthachalam Kannan, Leonardo Trasande, Vincent W.V. Jaddoe
Journal: Environmental Health Perspectives (2022)

Background: Fetal exposure to endocrine-disrupting chemicals such as phthalates and bisphenols might lead to fetal cardiovascular developmental adaptations and predispose individuals to cardiovascular disease in later life. Objectives: We examined the associations of maternal urinary bisphenol and phthalate concentrations in pregnancy with offspring carotid intima-media thickness and distensibility at the age of 10 y. Methods: In a population-based, prospective cohort study of 935 mother–child pairs, we measured maternal urinary phthalate and bisphenol concentrations at each trimester. Later, we measured child carotid intima-media thickness and distensibility in the children at age 10 y using ultrasound. Results: Maternal urinary average or trimester-specific phthalate concentrations were not associated with child carotid intima-media thickness at age 10 y. Higher maternal average concentrations of total bisphenol, especially bisphenol A, were associated with a lower carotid intima-media thickness [differences −0.15 standard deviation score and 95% confidence interval (CI): −0.24, −0.09 and −0.13 (95% CI: −0.22, −0.04) per interquartile range (IQR) increase in maternal urinary total bisphenol and bisphenol A concentration]. Trimester-specific analysis showed that higher maternal third-trimester total bisphenol and bisphenol A concentrations were associated with lower child carotid intima-media thickness [differences −0.13 (95% CI: −0.22, −0.04) and −0.13 (95% CI: −0.22, −0.05) per IQR increase in maternal urinary bisphenol concentration]. Maternal urinary bisphenol or phthalate concentrations were not associated with child carotid distensibility. DISCUSSION: In this large prospective cohort, higher maternal urinary bisphenols concentrations were associated with smaller childhood carotid intima-media thickness. Further studies are needed to replicate this association and to identify potential underlying mechanisms. https://doi.org/10.1289/EHP10293
Association of<i>T</i><i>P53</i>and<i>CDKN2A</i>Mutation Profile with Tumor Mutation Burden in Head and Neck Cancer
Authors: Alexander Y. Deneka, Yasmine Baca, Ilya G. Serebriiskii, Emmanuelle Nicolas, Mitchell I. Parker, Theodore T. Nguyen, Joanne Xiu, W. Michael Korn, Michael J. Demeure, Trisha Wise-Draper, Ammar Sukari, Barbara Burtness, Erica A. Golemis
Journal: Clinical Cancer Research (2022)

Head and neck squamous cell carcinoma (HNSCC) is a frequently devastating cancer that affects more than a half million people annually worldwide. Although some cases arise from infection with human papillomavirus (HPV), HPV-negative HNSCC is more common, and associated with worse outcome. Advanced HPV-negative HNSCC may be treated with surgery, chemoradiation, targeted therapy, or immune checkpoint inhibition (ICI). There is considerable need for predictive biomarkers for these treatments. Defects in DNA repair capacity and loss of cell-cycle checkpoints sensitize tumors to cytotoxic therapies, and can contribute to phenotypes such as elevated tumor mutation burden (TMB), associated with response to ICI. Mutation of the tumor suppressors and checkpoint mediators TP53 and CDKN2A is common in HPV-negative HNSCC.
Enhanced osteoarthritis therapy by nanoengineered mesenchymal stem cells using biomimetic CuS nanoparticles loaded with plasmid DNA encoding TGF-β1
Authors: Yu Cai, Cuixi Wu, Qianhua Ou, Muhui Zeng, Song Xue, Jieli Chen, Yao Lu, Changhai Ding
Journal: Bioactive Materials (2022)

Mesenchymal stem cells (MSCs) therapy shows the potential benefits to relieve clinical symptoms of osteoarthritis (OA), but it is uncertain if it can repair articular cartilage lesions - the main pathology of OA. Here, we prepared biomimetic cupper sulfide@phosphatidylcholine (CuS@PC) nanoparticles (NPs) loaded with plasmid DNA (pDNA) encoding transforming growth factor-beta 1 (TGF-β1) to engineer MSCs for enhanced OA therapy via cartilage regeneration. We found that the NPs not only promoted cell proliferation and migration, but also presented a higher pDNA transfection efficiency relative to commercial transfection reagent lipofectamine 3000. The resultant CuS/TGF-β1@PC NP-engineered MSCs (termed CTP-MSCs) were better than pure MSCs in terms of chondrogenic gene expression, glycosaminoglycan deposition and type II collagen formation, favoring cartilage repair. Further, CTP-MSCs inhibited extracellular matrix degradation in interleukin-1β-induced chondrocytes. Consequently, intraarticular administration of CTP-MSCs significantly enhanced the repair of damaged cartilage, whereas pure MSCs exhibited very limited effects on cartilage regeneration in destabilization of the medial meniscus (DMM) surgical instability mice. Hence, this work provides a new strategy to overcome the limitation of current stem cell therapy in OA treatment through developing more effective nanoengineered MSCs.
PROTAC Shrinks Mutated Prostate Tumors
Journal: Cancer Discovery (2022)

The most clinically advanced proteolysis-targeting chimera, bavdegalutamide, seems to work best against two molecularly defined subtypes of advanced prostate cancer. According to phase I/II trial data presented at the 2022 American Society of Clinical Oncology Genitourinary Cancers Symposium, the androgen receptor degrader most commonly shows antitumor activity among patients with T878X or H875Y mutations.
Clinicopathologic and molecular analyses of cutaneous leiomyosarcoma: A retrospective, multicenter study of 79 cases
Authors: Camille Planet, Stéphane Dalle, Olivier Dereure, Pierre-Emmanuel Stoebner, Marie-Christine Picot, Marion Soler, Laurent Meunier, Nathalie Cardot-Leccia, Valérie Kubiniek, Ilaria Di Mauro, Michael Delhorbe, Jean-Philippe Lacour, Thierry Passeron, Florence Pedeutour, Henri Montaudié, Bérengère Dadone-Montaudié
Journal: Journal of the American Academy of Dermatology (2022)
Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis
Authors: Fadi E. Pulous, Jean C. Cruz-Hernández, Chongbo Yang, Ζeynep Kaya, Alexandre Paccalet, Gregory Wojtkiewicz, Diane Capen, Dennis Brown, Juwell W. Wu, Maximilian J. Schloss, Claudio Vinegoni, Dmitry Richter, Masahiro Yamazoe, Maarten Hulsmans, Noor Momin, Jana Grune, David Rohde, Cameron S. McAlpine, Peter Panizzi, Ralph Weissleder, Dong-Eog Kim, Filip K. Swirski, Charles P. Lin, Michael A. Moskowitz, Matthias Nahrendorf
Journal: Nature Neuroscience (2022)