Low-Molecular-Weight Heparin for Women With Unexplained Recurrent Pregnancy Loss
Authors: Elisabeth Pasquier, Luc de Saint Martin
Journal: Annals of Internal Medicine (2015)

Letters15 September 2015Low-Molecular-Weight Heparin for Women With Unexplained Recurrent Pregnancy LossElisabeth Pasquier, MD, PhD and Luc de Saint Martin, MD, PhDElisabeth Pasquier, MD, PhDFrom Brest University Hospital, Brest, France.Search for more papers by this author and Luc de Saint Martin, MD, PhDFrom Brest University Hospital, Brest, France.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-5137-2 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The results of Schleussner and colleagues' open-label trial (1) agree with those of our double-blind, placebo-controlled study published in April 2015 (2). According to both studies, LMWH did not increase the chance of a live birth in women with unexplained recurrent miscarriage. Cocooning remains the only validated therapeutic option.Of note, the live-birth rate in Schleussner and colleagues' study (approximately 86%) was higher than that reported in our study (70%) (2) and in the ALIFE (Anticoagulants for Living Foetuses) and HABENOX (Thromboprophylaxis for Recurrent Miscarriage in Women With or Without Thrombophilia) trials (3, 4). Most women with ...References1. Schleussner E, Kamin G, Seliger G, Rogenhofer N, Ebner S, Toth B, et al; ETHIG II group. Low-molecular-weight heparin for women with unexplained recurrent pregnancy loss: a multicenter trial with a minimization randomization scheme. Ann Intern Med. 2015;162:601-9. [PMID: 25938990] doi:10.7326/M14-2062 LinkGoogle Scholar2. Pasquier E, de Saint Martin L, Bohec C, Chauleur C, Bretelle F, Marhic G, et al. Enoxaparin for prevention of unexplained recurrent miscarriage: a multicenter randomized double-blind placebo-controlled trial. Blood. 2015;125:2200-5. [PMID: 25636341] doi:10.1182/blood-2014-11-610857 CrossrefMedlineGoogle Scholar3. Kaandorp SP, Goddijn M, van der Post JA, Hutten BA, Verhoeve HR, Hamulyák K, et al. Aspirin plus heparin or aspirin alone in women with recurrent miscarriage. N Engl J Med. 2010;362:1586-96. [PMID: 20335572] doi:10.1056/NEJMoa1000641 CrossrefMedlineGoogle Scholar4. Visser J, Ulander VM, Helmerhorst FM, Lampinen K, Morin-Papunen L, Bloemenkamp KW, et al. Thromboprophylaxis for recurrent miscarriage in women with or without thrombophilia. HABENOX: a randomised multicentre trial. Thromb Haemost. 2011;105:295-301. [PMID: 21103659] doi:10.1160/TH10-05-0334 CrossrefMedlineGoogle Scholar5. Schisterman EF, Silver RM, Lesher LL, Faraggi D, Wactawski-Wende J, Townsend JM, et al. Preconception low-dose aspirin and pregnancy outcomes: results from the EAGeR randomised trial. Lancet. 2014;384:29-36. [PMID: 24702835] doi:10.1016/S0140-6736(14)60157-4 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Brest University Hospital, Brest, France.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L15-0353. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoLow-Molecular-Weight Heparin for Women With Unexplained Recurrent Pregnancy Loss Ekkehard Schleussner , Gabriele Kamin , Gregor Seliger , Nina Rogenhofer , Susanne Ebner , Bettina Toth , Michael Schenk , Melanie Henes , Michael K. Bohlmann , Thorsten Fischer , Oana Brosteanu , Rupert Bauersachs , David Petroff , and Low-Molecular-Weight Heparin for Women With Unexplained Recurrent Pregnancy Loss Rucha Patil , Kanjaksha Ghosh , and Shrimati Shetty Low-Molecular-Weight Heparin for Women With Unexplained Recurrent Pregnancy Loss Ekkehard Schleussner and David Petroff Low-Molecular-Weight Heparin for Women With Unexplained Recurrent Pregnancy Loss Rucha Patil , Kanjaksha Ghosh , and Shrimati Shetty Low-Molecular-Weight Heparin for Women With Unexplained Recurrent Pregnancy Loss Ekkehard Schleussner and David Petroff Metrics 15 September 2015Volume 163, Issue 6Page: 484-485KeywordsBirthCaregiversConflicts of interestDisclosureForecastingLongitudinal studiesLow molecular weight heparinMiscarriagePregnancyUltrasound imaging ePublished: 15 September 2015 Issue Published: 15 September 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...