POS0124 QUALITY OF LIFE FOR PATIENTS WITH KNEE OSTEOARTHRITIS WITH OR WITHOUT PAIN SENSITIZATION
Authors: W. R. Goh, W. J. Ong, D. Chan, Y. Y. Leung
Journal: Annals of the Rheumatic Diseases (2021)

Background: Patients with central sensitization (CS) may have poorer quality of life (QOL). Objectives: We aim to evaluate whether different ways of classifying CS have an impact on a patient’s QOL among patients with knee osteoarthritis (KOA). Methods: We use the baseline pre-operative data from a cohort of consecutive KOA patients enlisted for knee replacement surgery (1). We collected demographics, number and position of painful sites of body. Quality of life was assessed by the Medical Outcome Survey Short-Form 36 (SF-36). Pain pressure threshold was measured at volar side of right forearm. We classify CS using three sets of criteria: 1). widespread pain (pain involving both upper/ lower trunk, and both side of body), 2). lowest 10 th percentile of pressure pain threshold (PPT) measured at the forearm and 3) the painDETECT questionnaire &gt;=13/38. Results: Of 233 patients (79.8% women) with complete data set for analysis, mean (standard deviation, SD) age was 66.0 (8.3) years. 15.5%, 25.8%, and 4.7% of patients were classified as having CS by widespread pain, low PPT and painDETECT criteria. KOA patients with CS have poorer QoL compared with those without. Low PPT identified patients with poorer general health, while widespread pain and PainDETECT criteria identified patients with poorer QoL in more domains including vitality mental health (Table 1). Table 1. Quality of life comparing patients with or without CS Widespread pain lowest 10 th percentile of forearm PPT PainDETECT &gt;=13/38 No (n = 197) Yes (n= 36) No (n= 206) Yes (n= 27) No (n= 222) Yes (n= 11) SF-Physical functioning 39.0 (21.8) 32.6 (19.0) 38.7 (21.8) 32.8 (17.8) 38.8 (21.3) 22.3 (19.2)* SF-Role physical 21.6 (33.3) 8.3 (22.4)* 20.3 (32.2) 13.9 (32.0) 19.7 (32.6) 15.9 (23.1) SF-Bodily pain 36.3 (19.5) 28.1 (14.0)* 35.1 (19.5) 34.0 (14.7) 35.5 (19.1) 24.2 (13.3) SF-General health 68.9 (21.1) 64.6 (20.3) 69.4 (20.6) 59.3 (22.4)* 68.7 (20.7) 58.4 (25.7) SF-Vitality score 69.7 (22.4) 59.3 (20.4)** 68.8 (22.5) 63.1 (21.1) 69.0 (21.8) 51.8 (29.2)* SF-Social functioning 57.7 (37.2) 48.3 (39.2) 57.3 (38.0) 48.1 (33.7) 56.7 (37.7) 47.7 (42.1) SF-Role emotion 86.1 (34.4) 86.1 (33.2) 86.7 (33.5) 79.0 (38.3) 86.9 (32.9) 63.6 (50.5) SF-Mental health 82.4 (16.2) 77.4 (19.2) 82.2 (16.8) 77.8 (15.8) 82.2 (16.3) 70.2 (22.2)* Physical component score 32.5 (10.1) 30.3 (8.0) 32.4 (9.8) 30.6 (9.7) 32.4 (9.9) 28.8 (8.7) Mental component score 53.0 (10.5) 48.3 (10.0)* 52.7 (10.6) 48.5 (9.2) 52.6 (10.2) 44.2 (13.7)** * p&lt;0.05; **p&lt;0.01 Conclusion: KOA patients who have CS have poorer QoL compared to those without. Different criteria defined patients with different pattern of QoL impacts. In general, KOA patients who have CS have poorer QoL compared to those without. This highlight the importance of additional impact of CS to QoL References: [1]Leung YY, Lim Z, Fan Q, et al. Pre-operative pressure pain thresholds do not meaningfully explain satisfaction or improvement in pain after knee replacement: a cohort study. Osteoarthritis and cartilage 2019;27(1):49-58. Disclosure of Interests: None declared