tbuckley/cabot-search huggingface dataset:
COVID-19: a catalyst for flexibility and creativity in neurology
Authors: None The Lancet Neurology
Journal: The Lancet Neurology (2020)

The European Academy of Neurology (EAN) Congress took place virtually this year, on May 23–26. The event attracted more than 42 000 participants, compared with around 6000 participants in previous years. Somewhat surprisingly, the Congress has reached a very different audience—only 30% was European (compared with around 80% in previous years); about 40% were neurology residents or students (few typically participate due to the cost of travel); and around 30% were from South America, which is completely new.
An Oral Contraceptive
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A purine metabolic checkpoint that prevents autoimmunity and autoinflammation
Authors: Svetlana Saveljeva, Gavin W. Sewell, Katharina Ramshorn, M. Zaeem Cader, James A. West, Simon Clare, Lea-Maxie Haag, Rodrigo Pereira de Almeida Rodrigues, Lukas W. Unger, Ana Belén Iglesias-Romero, Lorraine M. Holland, Christophe Bourges, Muhammad N. Md-Ibrahim, James O. Jones, Richard S. Blumberg, James C. Lee, Nicole C. Kaneider, Trevor D. Lawley, Allan Bradley, Gordon Dougan, Arthur Kaser
Journal: Cell Metabolism (2022)

Still's disease, the paradigm of autoinflammation-cum-autoimmunity, predisposes for a cytokine storm with excessive T lymphocyte activation upon viral infection. Loss of function of the purine nucleoside enzyme FAMIN is the sole known cause for monogenic Still's disease. Here we discovered that a FAMIN-enabled purine metabolon in dendritic cells (DCs) restrains CD4+ and CD8+ T cell priming. DCs with absent FAMIN activity prime for enhanced antigen-specific cytotoxicity, IFNγ secretion, and T cell expansion, resulting in excessive influenza A virus-specific responses. Enhanced priming is already manifest with hypomorphic FAMIN-I254V, for which ∼6% of mankind is homozygous. FAMIN controls membrane trafficking and restrains antigen presentation in an NADH/NAD+-dependent manner by balancing flux through adenine-guanine nucleotide interconversion cycles. FAMIN additionally converts hypoxanthine into inosine, which DCs release to dampen T cell activation. Compromised FAMIN consequently enhances immunosurveillance of syngeneic tumors. FAMIN is a biochemical checkpoint that protects against excessive antiviral T cell responses, autoimmunity, and autoinflammation.
Angiotensin II plasma levels during chronic ACE inhibitor therapy are modulated by ACE insertion/deletion gene polymorphism Ralph Winkler, Markus Nauck, Willfried M�rz, Florian Mokler, B�rbel Klein, Rahime G�k, Jochen Senges, Bernhard R. Winkelmann. Herzzentrum Ludwigshafen, Ludwigshafen, Germany, Universit�t Freiburg, Freiburg, Germany
Journal: Journal of the American College of Cardiology (2001)
Deaths and Obituaries.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Beyond Our Pages
Authors: Burton Zweiman, Marc E. Rothenberg
Journal: Journal of Allergy and Clinical Immunology (2005)

Lung fibrosis occurs in numerous disease processes, including the chronic remodeling associated with asthma. Recent insight suggests that the related pathogenesis might involve dysregulated cytokine signaling in fibroblasts. In this article, the authors demonstrate that the Abelson tyrosine kinase (Abl) signals downstream from TGF in fibroblasts. Notably, inhibition of Abl with imatinib mesylate (Gleevec) prevented TGF-induced signaling, including collagen gene expression. In addition, using a mouse model of bleomycin-induced pulmonary fibrosis, the investigators demonstrate significant inhibition of lung fibrosis with imatinib mesylate.
Claims and counterclaims over alleged adverse reaction in covid-19 vaccine in India
Journal: BMJ (2020)

Claims and counterclaims over alleged adverse reaction in covid-19 vaccine in IndiaThe Indian manufacturer of the Oxford-AstraZeneca candidate vaccine against covid-19 (the Serum Institute of India) has threatened to claim Rs1bn (£10m; €11.2m; $13m) in damages from a clinical trial volunteer who alleges he developed a neurological illness after receiving the vaccine and has claimed Rs50m compensation.
Abstract 259: Characteristics of Patients With Sudden in Hospital Cardiac Arrest With a Shockable Initial Rhythm in a System With Mature Rapid Response and Code Blue Teams
Authors: Stephen Chong, Nicole Brenner, Paul Benz, Stephanie Woo, Matthew Wilson, Sheryl Titus, Jeffrey Dubin, Munish Goyal
Journal: Circulation (2018)

Study Objectives: Every year 33,000 people suffer an IHCA with an initial shockable rhythm in the US. Rapid Response Teams may increase time to defibrillation and are not associated with lower in-hospital mortality. We sought to describe characteristics of sudden IHCAs with a shockable initial rhythm in a system with mature Rapid Response and Code Blue teams, in particular, time to defibrillation. Methods: Retrospective chart review at a large, urban teaching hospital with mature Rapid Response and Code Blue teams. Adults in whom a “Code Blue” was called with confirmed cardiac arrest between Jan 2017 and Mar 2018 were included. Codes with incomplete data or that occurred in the ED or ICU were excluded. The “Code Blue” team consists of 1-3 Nurse Responders, a nursing supervisor, a respiratory therapist, Anesthesiology, a critical care resident, and a surgical resident. Each ward has a defibrillator and standardized code cart. Trained and supervised research assistants used a standardized data collection tool to extract demographic information, comorbidities and event related data from code sheets, history and physical, progress notes, discharge and death summaries. Events were categorized by initial rhythm as shockable or non-shockable. Time to defibrillation was defined as the interval from reported time of initial recognition of cardiac arrest to the reported time of first attempted defibrillation. Fisher’s exact testing was used to test for statistical significance. Results: A total of 183 “Code Blues” met criteria. Demographics: 71% black; mean age 65; and 46% women. Fifty-five (30%) survived to hospital discharge. Forty (21.3%) had an initial shockable rhythm of whom 21 (52.5%) survived to hospital discharge. Of the 40 patients that had an initial shockable rhythm, 36 were defibrillated. Median time to defibrillation was 2 minutes [IQR = 1-4]. Of those defibrillated within 2 minutes, survival was 64% vs 33% (P = 0.102) among those defibrillated in &gt; 2 minutes. Of the 143 patients that had a nonshockable initial rhythm, 34 (23.8%) survived to hospital discharge. Conclusion: In a system with mature Rapid Response and Code Blue teams, time to defibrillation among IHCA patients with a shockable initial rhythm is 2 minutes.
HSP47 in early vascular remodeling Alexander Jabs, Silvia Lentini, Juan J. Badimon, Valentin Fuster, Berndt L�deritz, Gerhard Bauriedel. Department of Cardiology, University of Bonn, Bonn, Germany, Cardiovascular Institute, Mount Sinai Medical Center, New York, NY
Journal: Journal of the American College of Cardiology (2001)
Neuroendocrine tumors: Ten years of experience in a Mexican oncology reference center.
Authors: Eduardo Rey Torres-Cisneros, Alan Burguete-Torres, Sergio Buenaventura Cisneros, Carla Renata Bruni-Guerrero, Blanca Otilia Wimer-Castillo, David Hernández-Barajas, Oscar Vidal-Gutiérrez, Carlos Eduardo Salazar-Mejía
Journal: Journal of Clinical Oncology (2022)

503 Background: Neuroendocrine tumors (NETs) are infrequent neoplasms that originate in the neuroendocrine cells of the embryological endoderm. Few data exist about the epidemiology and clinical characteristics of these tumors in the Mexican population. Methods: We performed a retrospective analysis of patients with pathology-confirmed NET treated at an Oncology Reference Center in North-East Mexico from 2010 to 2019. Clinical characteristics were recorded and an evaluation of overall survival (OS) using the Kaplan-Meier method was performed. Results: Fifty-three patients were included in the final analysis. The mean age at diagnosis was 54 +/- 16.36 years and 53% were men. Primarily affected sites were the gastroenteropancreatic tract [GEP] (47%), lung and mediastinum (21%), unknown primary (21%), and others (11%). Regarding the clinical stage at presentation, 22.6% of patients with NETs had localized disease, while 22.6% had regional spread and 54.7% were considered to have metastatic disease at diagnosis. Median OS was 42 months for all patients with NETs. In the GEP group, the median OS was 64 months, whereas for the lung/ mediastinum group was 8 months and for the unknown primary group was 5 months. Median OS stratified by stage was as follows: Localized disease: Not reached (NR), locoregional (20 months), and metastatic disease (8 months). Conclusions: To our knowledge, this is the first study published in English literature reporting the clinical characteristics and survival of Mexican patients with NETs. It is necessary to expand the information regarding these neoplasms to improve access of these patients to standard treatments and therefore improve their outcomes.
Manuscripts Approved for JNCI During March–April 1976
Journal: JNCI Journal of the National Cancer Institute (1976)

Manuscripts Approved for JNCI During March–April 1976 JNCI: Journal of the National Cancer Institute, Volume 56, Issue 5, May 1976, Pages 1087–1089, https://doi.org/10.1093/jnci/56.5.1087-d Published: 01 May 1976
Abstract 86: Mapping and Inducing Ventricular Tachycardia in Cardiomyopathic Animal Models
Authors: Ike Chinyere, Kyle Weigand, Talal Moukabary, Russell Witte, Miensheng Chu, Stefanie Novak, Mathew Hutchinson, Jordan Lancaster, Carol Gregorio, Steven Goldman, Elizabeth Juneman
Journal: Circulation Research (2017)

Introduction: In the United States, one in three deaths is attributed to cardiovascular disease (CVD). With CVD, sudden cardiac death is a common cause of mortality, specifically by way of ventricular tachycardia (VT) and ventricular fibrillation. We propose the application of our custom software to evaluate the electrophysiologic (EP) properties of animal models of ischemic and non-ischemic dilated cardiomyopathies. Methods: Adult male Sprague-Dawley rats with left coronary artery ligation and adult male and female transgenic Fragile X cardiomyopathic mice were sedated with Inactin and Isoflurane, respectively, and underwent hemodynamic measurements and/or EP testing. Using a PowerLab system and LabChart software, three-lead electrocardiograms were recorded. Using a pressure catheter, hemodynamic parameters were calculated. Using a concentric microelectrode (World Precision Inc.), a clinical EP catheter (Bard Inc.), and custom MATLAB software, local epicardial monophasic action potentials (MAP) and local epicardial voltages were recorded. Using custom MATLAB software for programmed electrical stimulation (PES), VT was induced epicardially with a clinically-accepted drivetrain. Animals underwent eight equidistant ‘S1’ stimulations followed by a premature ‘S2’ stimulation. The S2 stimulation was decreased by 5 milliseconds until loss of capture, indicating the effective refractory period. Sustained ventricular tachycardia (sVT) has been defined as more than fifteen consecutive premature ventricular contractions. Results: The chronic heart failure (CHF) rats had documented hemodynamic heart failure with elevated LV EDPs, and decreased EFs. Mapping and PES was performed on the two groups of rats, namely CHF and Sham-operated. In the CHF group, 71% (27/39) of the rats exhibited sVT, while 0% (0/10) of the Sham-operated rats exhibited sVT. Mapping was also performed on the two groups of mice, namely Wild-Type and Fragile X. Conclusions: We have performed clinically-relevant EP studies in CHF rats and in Fragile X dilated cardiomyopathic mice. These EP studies demonstrate our ability to evaluate and validate the phenotypes of animal models of cardiomyopathies and demonstrate the potential to evaluate the effectiveness of new therapies.
Pandemic school closures: risks and opportunities
Authors: None The Lancet Child & Adolescent Health
Journal: The Lancet Child & Adolescent Health (2020)

The novel coronavirus disease 2019 (COVID-19) has swept across 210 countries and territories with over 1·2 million cases and 67 594 deaths reported by April 6, 2020. Most countries have implemented social distancing measures to curb the spread of infection and minimise the impact of the virus.
More time and better continuity improve outcome at general practice consultations
Journal: BMJ (1999)

Decision aids do improve patients' decision makingTrials of aids to help patients consider the benefits and harms of medical treatments show that they improve patients' knowledge, comfort, and participation in decision making without increasing anxiety.The systematic review by O'Connor et al (p 731) also found that decision aids had little effect on satisfaction and an inconsistent effect on patients' decisions.The trials of decision aids focused on hormone therapy, circumcision, screening for cancer and genetic disorders, and treatments for prostate cancer, breast cancer, and heart disease.The results consistently showed that decision aids were better than usual practice.
Online-Only Abstracts
Authors: P Gautret, R Charrel, K Belhouchat, T Drali, S Benkouiten, A Nougairede, C Zandotti, Z Memish, M Al Masri, C Gaillard, P Brouqui, P Parola, F Falasca, C Montagna, P Maida, M Bucci, A Fantauzzi, I Mezzaroma, G Antonelli, O Turriziani
Journal: Clinical Microbiology and Infection (2013)
Obituary Listing
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A multi-omics approach to identify molecular alterations in a mouse model of heart failure
Authors: Xiang Zhou, Shuchen Zhang, Yiheng Zhao, Wenjing Wang, Hao Zhang
Journal: Theranostics (2022)

Rationale:The morbidity and mortality of heart failure (HF) have been increasing rapidly in recent years.However, the molecular events that link to the phenotype of HF remain unclear.This study aimed to investigate the molecular alterations in the pathogenesis of HF induced by pressure overload.Methods: Transverse aortic constriction was conducted to generate the HF mouse model.A multi-omics study was performed, including integrative analysis of scRNA-seq, scATAC-seq, bulk ATAC-seq and miRNA-seq data.The results of omics analysis were verified by immunofluorescence staining.Results: scRNA-seq analysis identified five major cell types, which exhibits consistency with previous studies.Integrative analysis of ATAC-seq and miRNA-seq showed the alterations of gene expression in HF.Activation of genes involved in immune response at transcriptional level and perturbed expression of their upstream miRNAs confirmed the function of immune cells in the pathogenesis of HF.Analysis of scATAC-seq revealed a NO biosynthetic related gene regulation pattern in endothelial cells of failing hearts. Conclusion:We performed a multi-omics analysis, comparing the transcriptomic, miRNA expression, and chromatin accessibility profile between the HF and control mice, thus providing mechanistic insights into the pathogenesis of pressure overload-induced HF.
Is IIb/IIIa blockade state-of-the-art for catheter based reperfusion? A meta-analysis of five randomized trials in acute myocardial infarction Umesh N. Khot, Franz-Josef Neumann, Sorin J. Brener, Albert Schomig, Gilles Montalescot, Shelly Sapp, Eric J. Topol. The Cleveland Clinic Foundation, Cleveland, OH
Journal: Journal of the American College of Cardiology (2001)
Accessibility and Accuracy of Web Page References in 5 Major Medical Journals—Correction
Authors: Peter Breese, William Burman
Journal: JAMA (2005)

institution.It is possible that the patient population of some institutions differs from the surrounding population in important ways.Despite these limitations, our study demonstrates that notices of privacy practices are lengthy and contain complex language that is unlikely to be understood by a considerable proportion of the populations served by topranked US health care institutions.If the purpose of the HIPAA legislation is to improve communication between patient and clinician, the documents used to do so need to be changed.
Age-associated mutations in RAS-mutated versus RAS-nonmutated metastatic colorectal cancer.
Authors: Madappa N. Kundranda, Ariane C. Kemkes, Josh Routh, Jean-Paul De La O, Mark C. Evans, Cynthia A. Flannery, David W. Hall, Nishitha Therala, Michelle Turner, Snehal Govind Thakkar
Journal: Journal of Clinical Oncology (2022)

171 Background: Mutational profiling is recommended for selecting targeted therapy for metastatic colorectal cancer (mCRC). Evidence suggests that among patients with mutations in one of three RAS genes who underwent resection of liver metastasis, those with early onset mCRC had worse outcomes compared to those with late onset mCRC. The goal of this study was to explore whether other mutated genes in mCRC exhibit an association between age and wild type versus mutant RAS status. Methods: Between October 2018 and October 2020, 974 tumor samples from patients with mCRC were identified. Samples meeting requirements were profiled with the Oncotype MAP Pan-Cancer Tissue test, which sequences 257 genes from tumor tissue, including all 3 RAS genes ( HRAS, KRAS, NRAS). Using the Oncotype MAP assay, single base variants, indels, copy number alterations and structural variants/fusions were identified. Tumor mutational burden (TMB) and microsatellite instability (MSI) were also determined. To identify genes for which there was an association between age group (patients ≤50 years vs &gt;50 years) and RAS status we used Fisher’s Exact Test. Results: Of the 974 samples, 840 met minimum tumor tissue requirements for DNA sequencing (3mm 2 and 15% tumor cellularity). Of these, 759 samples were successfully sequenced for NGS. Median turnaround time from the date of sample accessioning to the date of laboratory report was 5 days (interquartile range, IQR, 4-6 days). TMB varied from 0-227 mutations per megabase (median 6, IQR 4-8), and was high (≥10 mut/Mb) in 117 samples (15%). Of 775 specimens processed for MSI, 714 could be measured and approximately 7% were MSI-high. A total of 496 RAS variants were identified, of which 391 were pathogenic, likely pathogenic, or variants of unknown significance (349 KRAS, 34 NRAS, 8 HRAS). Of the 27 genes with at least 78 mutations in the data set, there was an association between RAS status and patient age for mutations at SMAD4, ABCC1, and RICTOR (Fisher’s Exact test, P &lt; 0.05). For all three, mutations at these genes are relatively more prevalent in samples from young RAS wild type patients compared to young RAS mutant patients (Table). Conclusions: The Oncotype MAP Pan-Cancer Tissue test identified numerous genomic changes in mCRC samples. There appears to be an association between age group and RAS status for three mutated genes, SMAD4, ABCC1, and RICTOR. The clinical implication is unclear and warrants further investigation with outcomes data.[Table: see text]
Scalpel, Sword and Stretcher: Forty Years of Work and Play.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal