tbuckley/cabot-search huggingface dataset:
Compensatory CSF2-driven macrophage activation promotes adaptive resistance to CSF1R inhibition in breast-to-brain metastasis
Authors: Florian Klemm, Aylin Möckl, Anna Salamero-Boix, Tijna Alekseeva, Alexander Schäffer, Michael Schulz, Katja Niesel, Roeltje R. Maas, Marie Groth, Benelita T. Elie, Robert L. Bowman, Monika E. Hegi, Roy T. Daniel, Pia S. Zeiner, Jenny Zinke, Patrick N. Harter, Karl H. Plate, Johanna A. Joyce, Lisa Sevenich
Journal: Nature Cancer (2021)
Binge Drinking Among Adults, by Select Characteristics and State — United States, 2018
Authors: Michele K. Bohm, Yong Liu, Marissa B. Esser, Jessica B. Mesnick, Hua Lu, Yi Pan, Kurt J. Greenlund
Journal: MMWR Morbidity and Mortality Weekly Report (2021)

Excessive alcohol use* is associated with disease, injury, and poor pregnancy outcomes and is responsible for approximately 95,000 deaths in the United States each year (1). Binge drinking (five or more drinks on at least one occasion for men or four or more drinks for women) is the most common and costly pattern of excessive alcohol use (2). CDC analyzed data from the 2018 Behavioral Risk Factor Surveillance System (BRFSS) to estimate past 30-day binge drinking prevalence, frequency, and intensity (number of drinks per occasion), overall and by select characteristics and state. The overall unadjusted prevalence of binge drinking during the past 30 days was 16.6%, representing an estimated 38.5 million U.S. adults aged ≥18 years; prevalence was highest (26.0%) among those aged 25-34 years. The age-standardized binge drinking prevalence was higher among men (22.5%) than among women (12.6%), increased with income, and was highest among non-Hispanic White adults and adults in the Midwest Census region. State-level age-standardized binge drinking prevalence ranged from 10.5% (Utah) to 25.8% (Wisconsin). Among adults who reported binge drinking, 25.0% did so at least weekly, on average, and 25.0% consumed at least eight drinks on an occasion. To reduce binge drinking, the Community Preventive Services Task Force recommends increasing alcohol taxes and implementing strategies that strengthen regulations to reduce alcohol availability.† The U.S. Preventive Services Task Force recommends clinicians screen adults for alcohol misuse in primary care settings and provide counseling as needed.§.
The TeloDIAG: how telomeric parameters can help in glioma rapid diagnosis and liquid biopsy approaches
Authors: P. Billard, C. Guerriau, C. Carpentier, F. Juillard, N. Grandin, P. Lomonte, P. Kantapareddy, N. Dufay, M. Barritault, R. Rimokh, P. Verrelle, D. Maucort-Boulch, D. Figarella-Branger, F. Ducray, C. Dehais, M. Charbonneau, D. Meyronet, D.A. Poncet
Journal: Annals of Oncology (2021)
P11.03 SHR-1316 in Combination With Fluzoparib in Relapsed Small-Cell Lung Cancer: An Open-Label, Multicenter, Two-Stage, Phase Ⅰb Trial
Authors: Y. Fan, Z. Huang, J. Fang, A. Liu, Y. Xu, X. Ma, Y. Shen
Journal: Journal of Thoracic Oncology (2021)
MA07.01 Dynamic Liquid Biopsy During Immunotherapy Anticipates Hyperprogression And Early Death in Advanced Non-Small Cell Lung Cancer
Authors: L. Bonanno, E. Zulato, P. Del Bianco, G. Nardo, I. Attili, A. Pavan, A. Boscolo Bragadin, L. Marra, F. Calabrese, M. Fassan, G. Pasello, V. Guarneri, P. Conte, S. Indraccolo
Journal: Journal of Thoracic Oncology (2021)
Therapeutic supramolecular tubustecan hydrogel combined with checkpoint inhibitor elicits immunity to combat cancer
Authors: Feihu Wang, Hao Su, Dongqing Xu, Maya K. Monroe, Caleb F. Anderson, Weijie Zhang, Richard Oh, Zongyuan Wang, Xuanrong Sun, Han Wang, Fengyi Wan, Honggang Cui
Journal: Biomaterials (2021)
The role of PDGF-BB in the bone-vascular relationship during aging
Authors: Mone Zaidi, Daria Lizneva, Tony Yuen
Journal: Journal of Clinical Investigation (2021)

Cardiovascular disease (CVD) and osteoporosis often occur together, suggesting an association between CVD and bone loss. Similarly, the correlation of bone loss, atherosclerosis, and aortic calcification, especially in patients with chronic kidney disease, exemplifies a bone-vessel connection. In this issue of the JCI, Santhanam et al. investigated the role of the angiogenesis factor platelet-derived growth factor-BB (PDGF-BB) in vascular stiffening. Serum levels of bone-derived PDGF-BB differed between young and aged mice, and in mice fed a high-fat diet (HFD) compared with those fed normal chow. Experiments with genetic models led the authors to conclude that bone-derived PDGF-BB mediates the hallmark arterial stiffening of aging and metabolic stress. Notably, excessive preosteoclast-derived PDGF-BB production during aging inhibited osteoblastic bone formation and increased circulating PDGF-BB, which in turn, accelerated vascular stiffness. These findings suggest that modifying circulating PDGF-BB levels may benefit patients with CVD, osteoporosis, and other age-related diseases.
Differences in clinical deterioration among three sub-phenotypes of COVID-19 patients at the time of first positive test: results from a clustering analysis
Authors: Matthieu Legrand, Rachael V. Phillips, Ivana Malenica, Lauren Eyler, Nicholas Fong, Alessandro Martinino, Carmen Navas Jimenez, Juan-Pablo Scarano Pereira, Benjamin Lefevre, Antoine Kimmoun, Bridgette LaFaye, Andrew Bishara, Alan E. Hubbard, Vincent Mallet, Romain Pirracchio
Journal: Intensive Care Medicine (2020)
MA07.02 Evaluating Circulating Tumor DNA to Predict Overall Survival Risk in Non-Squamous Non-Small Cell Lung Cancer in IMpower150
Authors: Z.J. Assaf, A. Fine, W. Zou, M. Socinski, A. Young, J. Freidin, M. Kennedy, E. Polisecki, M. Nishio, G. Oxnard, C. Cummings, A. Rode, M. Reck, N. Patil, D. Shames, K. Schulz
Journal: Journal of Thoracic Oncology (2021)
P53.02 Efficacy and Safety of Larotrectinib in Patients With Tropomyosin Receptor Kinase (TRK) Fusion-Positive Lung Cancer
Authors: A. Drilon, J. Lin, U. Lassen, S. Leyvraz, Y. Liu, J. Patel, L. Rosen, B. Solomon, R. Norenberg, L. Dima, N. Brega, L. Shen, V. Moreno, S. Kummar, D. Tan
Journal: Journal of Thoracic Oncology (2021)
MA02.07 T-DM1 and Osimertinib (TRAEMOS) To Target HER2 Bypass Track Resistance in EGFRm+ NSCLC: Interim Analysis of a Phase II Trial
Authors: M. Jebbink, A.J. De Langen, K. Monkhorst, M.c. Boelens, D. Van Den Broek, V. Van Der Noort, C.J. De Gooijer, A.J. Van Der Wekken, L. Hendriks, S.M.S. Hashemi, M.S. Paats, A. Dingemans, E. Smit
Journal: Journal of Thoracic Oncology (2021)
Abstract 15694: Decreased Quality of Life in Patients and Families Following a Diagnosis of Anomalous Aortic Origin of a Coronary Artery
Authors: Hitesh Agrawal, Carlos M Mery, Sarah Sami, S Kristen Sexson Tejtel, Athar M Qureshi, Cory V Noel, Prakash Masand, Charles D Fraser, Silvana Molossi
Journal: Circulation (2017)

Introduction: Anomalous aortic origin of a coronary artery (AAOCA) may be associated with sudden cardiac arrest. We sought to determine whether quality of life (QOL) is impacted after a diagnosis o...
Navigating Nodal Metrics for Node-Positive Gastric Cancer in the United States: An NCDB-Based Study and Validation of AJCC Guidelines
Authors: Derek J. Erstad, Mariela Blum, Jeannelyn S. Estrella, Prajnan Das, Bruce D. Minsky, Jaffer A. Ajani, Paul F. Mansfield, Naruhiko Ikoma, Brian D. Badgwell
Journal: Journal of the National Comprehensive Cancer Network (2021)

Background: The optimal number of examined lymph nodes (ELNs) and the positive lymph node ratio (LNR) for potentially curable gastric cancer are not established. We sought to determine clinical benchmarks for these values using a large national database. Methods: Demographic, clinicopathologic, and treatment-related data from patients treated using an R0, curative-intent gastrectomy registered in the National Cancer Database during 2004 to 2016 were evaluated. Patients with node-positive (pTxN+M0) disease were considered for analysis. Results: A total of 22,018 patients met the inclusion criteria, with a median follow-up of 2.2 years. Mean age at diagnosis was 65.6 years, 66% were male, 68% were White, 33% of tumors were located near the gastroesophageal junction, and 29% of patients had undergone preoperative therapy. Most primary tumors (62%) were category pT3–4, 67% had a poor or anaplastic grade, and 19% had signet features. Clinical nodal staging was inaccurate compared with staging at final pathology. The mean [SD] number of nodes examined was 19 [11]. On multivariable analysis, the pN category, ELNs, and LNR were independently associated with survival (all P &lt;.0001). Using receiver operating characteristic (ROC) analysis, an optimal ELN threshold of ≥30 was established for patients with pN3b disease and was applied to the entire cohort. Node positivity and LNR had minimal change beyond 30 examined nodes. Stage-specific LNR thresholds calculated by ROC analysis were 11% for pN1, 28% for pN2, 58% for pN3a, 64% for pN3b, 30% for total combined. By using an ELN threshold of ≥30, prognostically advantageous stage-specific LNR values could be determined for 96% of evaluated patients. Conclusions: Using a large national cancer registry, we determined that an ELN threshold of ≥30 allowed for prognostically advantageous LNRs to be achieved in 96% of patients. Therefore, ≥30 examined nodes should be considered a clinical benchmark for practice in the United States.
<i>Akkermansia muciniphila</i>: is it the Holy Grail for ameliorating metabolic diseases?
Authors: Juan Yan, Lili Sheng, Houkai Li
Journal: Gut Microbes (2021)

The increasing prevalence of metabolic diseases has become a severe public health problem. Gut microbiota play important roles in maintaining human health by modulating the host's metabolism. Recent evidences demonstrate that Akkermansia muciniphila is effective in improving metabolic disorders and is thus considered as a promising "next-generation beneficial microbe". In addition to the live A. muciniphila, similar or even stronger beneficial effects have been observed in pasteurized A. muciniphila and its components, including the outer membrane protein Amuc_1100, A. muciniphila-derived extracellular vesicles (AmEVs), and secreted protein P9. Hence, this paper presents a systemic review of recent progress in the effects and mechanisms of A. muciniphila and its components in the treatment of metabolic diseases, including obesity, type 2 diabetes mellitus, cardiovascular disease, and nonalcoholic fatty liver disease, as well as perspectives on its future study.
“Exhausted and depleted” staff pose risk to quality of NHS and social care, warns CQC
Authors: Ingrid Torjesen
Journal: BMJ (2021)

The health and social care workforce is drained of resilience and capacity, from sustained pressure during the pandemic, and this will have consequences for the quality of care if it is not tackled, the Care Quality Commission has warned.

“The negative impact of working under this sustained pressure, including anxiety, stress, and burnout, cannot be underestimated,” said the CQC in its annual assessment of the state of health and social care in England.1 “As we approach winter, the workforce who face the challenges ahead are exhausted and depleted, which has implications for the quality of care. They cannot work any harder—they need support to work differently.”

NHS staff were surrounded by serious illness and death at unprecedented levels during the pandemic, while often struggling for support and resources, the report said. Around 19% were redeployed, and 34% were working on covid-19 …
Helen Salisbury: Sajid Javid’s missed opportunity
Authors: Helen Salisbury
Journal: BMJ (2021)

England’s secretary of state for health and social care did not attend his face-to-face appointment with 1500 GPs at their annual conference last week. He was offered the opportunity of a video consultation, but he turned that down too.

When patients don’t turn up, GPs have mixed reactions. The first usually includes relief, as it gives us some time to catch up. The second is irritation, as another patient would gladly have used that slot. The third is an awareness of a wasted opportunity to build a relationship with a patient (it’s often our more difficult patients who miss appointments) or to help them improve their health.

It would have been good if Sajid …
Relationship between type 2 cytokine and inflammasome responses in obesity-associated asthma
Authors: James W. Pinkerton, Richard Y. Kim, Alexandra C. Brown, Brittany E. Rae, Chantal Donovan, Jemma R. Mayall, Olivia R. Carroll, Md. Khadem Ali, Hayley A. Scott, Bronwyn S. Berthon, Katherine J. Baines, Malcolm R. Starkey, Nazanin Z. Kermani, Yi-Ke Guo, Avril A.B. Robertson, Luke A.J. O’Neill, Ian M. Adcock, Matthew A. Cooper, Peter G. Gibson, Lisa G. Wood, Philip M. Hansbro, Jay C. Horvat
Journal: Journal of Allergy and Clinical Immunology (2021)
P57.03 Cellular Engagement and Interaction in the Tumor Microenvironment (TME) Predicts Response to ICI in Metastatic NSCLC
Authors: A. Qin, F. Lima, S. Bell, G. Kalemkerian, B. Schneider, N. Ramnath, M. Lew, A. Rao, T. Frankel
Journal: Journal of Thoracic Oncology (2021)
P31.06 Impact of Covid-19 Infection on Lung Cancer Patients: Experience in Latin-American Country ACHOCC-19L Study
Authors: A.V. Ospina Serrano, R. Bruges, W. Mantilla, I. Triana, P. Ramos, S. Aruachan, A. Quiroga, I. Munevar, J. Ortiz, N. Llinas, P. Pinilla, H. Vargas, H. Idrobo, A. Russi, R. Manneh, G. Rivas, H. Gonzalez, D. Santa, J. Insuasty, L. Bernal, J. Otero, C. Vargas, J. Pacheco, C. Alcala, P. Jimenez, M. Lombana, F. Contreras, J. Segovia, L. Pino, J. Lobaton, M. Gonzalez, J. Cuello, J. Bogoya, R. Duarte, A. Barrero
Journal: Journal of Thoracic Oncology (2021)
Aberrant hepatic trafficking of gut‐derived T cells is not specific to primary sclerosing cholangitis
Authors: Jonathon J. Graham, Sujit Mukherjee, Muhammad Yuksel, Rebeca Sanabria Mateos, Tengfei Si, Zhenlin Huang, Xiahong Huang, Hadil Abu Arqoub, Vishal Patel, Mark McPhail, Yoh Zen, Nigel Heaton, Maria Serena Longhi, Michael A. Heneghan, Rodrigo Liberal, Diego Vergani, Giorgina Mieli‐Vergani, Yun Ma, Bu’Hussain Hayee
Journal: Hepatology (2021)

The "gut homing" hypothesis suggests the pathogenesis of primary sclerosing cholangitis (PSC) is driven by aberrant hepatic expression of gut adhesion molecules and subsequent recruitment of gut-derived T cells to the liver. However, inconsistencies lie within this theory including an absence of investigations and comparisons with other chronic liver diseases (CLD). Here, we examine "the gut homing theory" in patients with PSC with associated inflammatory bowel disease (PSC-IBD) and across multiple inflammatory liver diseases.Expression of MAdCAM-1, CCL25, and E-Cadherin were assessed histologically and using RT-PCR on explanted liver tissue from patients with CLD undergoing OLT and in normal liver. Liver mononuclear cells were isolated from explanted tissue samples and the expression of gut homing integrins and cytokines on hepatic infiltrating gut-derived T cells was assessed using flow cytometry. Hepatic expression of MAdCAM-1, CCL25 and E-Cadherin was up-regulated in all CLDs compared with normal liver. There were no differences between disease groups. Frequencies of α4β7, αEβ7, CCR9, and GPR15 expressing hepatic T cells was increased in PSC-IBD, but also in CLD controls, compared with normal liver. β7 expressing hepatic T cells displayed an increased inflammatory phenotype compared with β7 negative cells, although this inflammatory cytokine profile was present in both the inflamed and normal liver.These findings refute the widely accepted "gut homing" hypothesis as the primary driver of PSC and indicate that aberrant hepatic recruitment of gut-derived T cells is not unique to PSC, but is a panetiological feature of CLD.
Lung cancer survival and sex-specific patterns in Portugal: A population-based analysis
Authors: T. Guerreiro, G. Forjaz, L. Antunes, J. Bastos, A. Mayer, P. Aguiar, A. Araújo, C. Nunes
Journal: Pulmonology (2021)

In Portugal, lung cancer (LC) is the first cause of cancer-related death and of death and disability combined. This study aims to analyze the overall survival (OS) and relative survival (RS) of patients diagnosed with LC in 2009-2011 by socio-demographic and tumor characteristics, and analyze sex-specific patterns.We estimated 5-year OS using the Kaplan-Meier method and 5-year net survival through the RS framework. Cox regression modeling was used to determine the hazard ratio (HR) of death associated with each independent variable.For the 11,523 cases analyzed, median 5-year OS was 264 days (95% confidence interval [CI]: 254.8-273.2), the cumulative OS was 13.6% and RS was 15.1%. Males had a lower median survival (237 days; 95% CI: 228.2-245.7) compared to females (416 days; 95% CI: 384.4-447.6) (p < 0.0001) and lower 5-year RS proportions (12.1% vs. 24.9%). RS progressively decreased with age (41.7% for age-group <40 to 7.2% for ≥80) and stage (66.6% for stage I to 2.4% for stage IV). As predictors of decreased survival, we identified male gender, increasing age >50, histologic types (squamous cell carcinoma, non-small cell lung cancer not otherwise specified, other unspecified and small cell lung cancer), and increasing stage. Compared to women, the risk of death in men was 37.7% higher (HR = 1.386; 95% CI: 1.295-1.484).The differences between OS and RS were small, reflecting the high lethality of LC. Male gender and older age are factors related to poor prognosis. Histology also plays a role in survival prognosis and varies with gender, but the factor related to the worst survival is stage. Although the study reflects data from a decade ago, and major changes occurred in diagnosis, staging and treatment, particularly for advanced disease, as LC mortality is strongly correlated with late stage diagnosis, all efforts should be made to secure early diagnosis and improve survival prospects.
Trend of Diabetes-Related Hospital Admissions During the Transition Period From Adolescence to Adulthood in the State of California
Authors: Angel Siu Ying Nip, Maya Lodish
Journal: Diabetes Care (2021)

This study examined the incidence of diabetes-related hospital admissions and described the characteristics among youth and emerging adults with type 1 (T1D) and type 2 diabetes (T2D) in California.A retrospective study was conducted using the statewide inpatient database during the years 2014-2018. Individuals aged 13-24 years hospitalized with diabetic ketoacidosis (DKA) or severe hypoglycemia (SH) were recorded. Demographic characteristics and health measures among youth (ages 13-18) and young adults (ages 19-24) were compared.A total of 34,749 admission encounters for T1D and 3,304 for T2D were analyzed. Hospitalization rates significantly increased with age during the transition to adulthood, from 70/100,000 California population at age 17 to 132/100,000 at age 19 in T1D. Higher hospitalization rates were demonstrated in young adults than in youth in T1D, and the rate was significantly higher in Black young adults (23.9%) than in youth (12.0%) among the age-adjusted population with diabetes (P < 0.0001). More young adults admitted were on public insurance, and approximately half were from the lowest income quartile. No difference was observed in hospital length of stay; however, hospital charges were higher among young adults. Young adults were three times more likely to be admitted for severe conditions.We demonstrated a significant rise in hospital admission during the transition period in individuals with T1D. There were significantly more Black young adults who were on public insurance and had lower socioeconomic status. Our findings suggest that the health care system fails many emerging adults with diabetes, particularly for people of color, and that improving medical transition is crucial.
The Reliability of Clinical Methods, Data and Judgments
Authors: Lorrin M. Koran
Journal: New England Journal of Medicine (1975)

Interpreting Diagnostic ProceduresElectrocardiograph (Table 3)Efforts are under way to minimize sources of observer disagreement in electrocardiographic interpretation by use of codes, averaging of readings, computer analysis, and other methods.35 36 37 Even with completely reliable computerized reading, the diagnostic implications of electrocardiographic changes depend on the patient's age, sex, and clinical situation. In the following studies, the clinical information available to the readers varied.Gorman and his associates30 compared two independent interpretations of an unselected series of 561 electrocardiograms of adult inpatients. The tracings were read first by one of three electrocardiographers and then by one . . .
Synergistic stimulation of surface topography and biphasic electric current promotes muscle regeneration
Authors: Indong Jun, Na Li, Jaehee Shin, Jaeho Park, Young Jun Kim, Hojeong Jeon, Hyuk Choi, Jae-Gu Cho, Byoung Chan Choi, Hyung-Seop Han, Jae-Jun Song
Journal: Bioactive Materials (2021)

Developing a universal culture platform that manipulates cell fate is one of the most important tasks in the investigation of the role of the cellular microenvironment. This study focuses on the application of topographical and electrical field stimuli to human myogenic precursor cell (hMPC) cultures to assess the influences of the adherent direction, proliferation, and differentiation, and induce preconditioning-induced therapeutic benefits. First, a topographical surface of commercially available culture dishes was achieved by femtosecond laser texturing. The detachable biphasic electrical current system was then applied to the hMPCs cultured on laser-textured culture dishes. Laser-textured topographies were remarkably effective in inducing the assembly of hMPC myotubes by enhancing the orientation of adherent hMPCs compared with flat surfaces. Furthermore, electrical field stimulation through laser-textured topographies was found to promote the expression of myogenic regulatory factors compared with nonstimulated cells. As such, we successfully demonstrated that the combined stimulation of topographical and electrical cues could effectively enhance the myogenic maturation of hMPCs in a surface spatial and electrical field-dependent manner, thus providing the basis for therapeutic strategies.