tbuckley/cabot-search huggingface dataset:
Hepatic FoxOs link insulin signaling with plasma lipoprotein metabolism through an apolipoprotein M/sphingosine-1-phosphate pathway
Authors: María Concepción Izquierdo, Niroshan Shanmugarajah, Samuel X. Lee, Michael J. Kraakman, Marit Westerterp, Takumi Kitamoto, Michael Harris, Joshua R. Cook, Galina A. Gusarova, Kendra Zhong, Elijah Marbuary, InSug O-Sullivan, Nikolaus Rasmus, Stefania Camastra, Terry G. Unterman, Ele Ferrannini, Barry E. Hurwitz, Rebecca A. Haeusler
Journal: Journal of Clinical Investigation (2022)

Multiple beneficial cardiovascular effects of HDL depend on sphingosine-1-phosphate (S1P). S1P associates with HDL by binding to apolipoprotein M (ApoM). Insulin resistance is a major driver of dyslipidemia and cardiovascular risk. However, the mechanisms linking alterations in insulin signaling with plasma lipoprotein metabolism are incompletely understood. The insulin-repressible FoxO transcription factors mediate key effects of hepatic insulin action on glucose and lipoprotein metabolism. This work tested whether hepatic insulin signaling regulates HDL-S1P and aimed to identify the underlying molecular mechanisms. We report that insulin-resistant, nondiabetic individuals had decreased HDL-S1P levels, but no change in total plasma S1P. This also occurred in insulin-resistant db/db mice, which had low ApoM and a specific reduction of S1P in the HDL fraction, with no change in total plasma S1P levels. Using mice lacking hepatic FoxOs (L-FoxO1,3,4), we found that hepatic FoxOs were required for ApoM expression. Total plasma S1P levels were similar to those in controls, but S1P was nearly absent from HDL and was instead increased in the lipoprotein-depleted plasma fraction. This phenotype was restored to normal by rescuing ApoM in L-FoxO1,3,4 mice. Our findings show that insulin resistance in humans and mice is associated with decreased HDL-associated S1P. Our study shows that hepatic FoxO transcription factors are regulators of the ApoM/S1P pathway.
THE ASSOCIATION OF APPENDICITIS WITH DISEASES OF THE GALL BLADDER,
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Definitive Prognostication System for Patients With Thoracic Malignancies Diagnosed With Coronavirus Disease 2019: An Update From the TERAVOLT Registry
Authors: Jennifer G. Whisenant, Javier Baena, Alessio Cortellini, Li-Ching Huang, Giuseppe Lo Russo, Luca Porcu, Selina K. Wong, Christine M. Bestvina, Matthew D. Hellmann, Elisa Roca, Hira Rizvi, Isabelle Monnet, Amel Boudjemaa, Jacobo Rogado, Giulia Pasello, Natasha B. Leighl, Oscar Arrieta, Avinash Aujayeb, Ullas Batra, Ahmed Y. Azzam, Mojca Unk, Mohammed A. Azab, Ardak N. Zhumagaliyeva, Carlos Gomez-Martin, Juan B. Blaquier, Erica Geraedts, Giannis Mountzios, Gloria Serrano-Montero, Niels Reinmuth, Linda Coate, Melina Marmarelis, Carolyn J. Presley, Fred R. Hirsch, Pilar Garrido, Hina Khan, Alice Baggi, Celine Mascaux, Balazs Halmos, Giovanni L. Ceresoli, Mary J. Fidler, Vieri Scotti, Anne-Cécile Métivier, Lionel Falchero, Enriqueta Felip, Carlo Genova, Julien Mazieres, Umit Tapan, Julie Brahmer, Emilio Bria, Sonam Puri, Sanjay Popat, Karen L. Reckamp, Floriana Morgillo, Ernest Nadal, Francesca Mazzoni, Francesco Agustoni, Jair Bar, Federica Grosso, Virginie Avrillon, Jyoti D. Patel, Fabio Gomes, Ehab Ibrahim, Annalisa Trama, Anna C. Bettini, Fabrice Barlesi, Anne-Marie Dingemans, Heather Wakelee, Solange Peters, Leora Horn, Marina Chiara Garassino, Valter Torri
Journal: Journal of Thoracic Oncology (2022)
Urologic Surgery
Authors: Irving M. Bush
Journal: JAMA (1969)

During the last 20 years urologic surgery has come of age. Combining basic principles with newer techniques and refinements, this ancient yet youthful specialty has recently become the focal point of dramatic surgical and endoscopic developments.<i>Urologic Surgery</i>reflects this growth. It will be of value to anyone concerned with one or more of the 19 major aspects of urology which it covers. It is an up-to-date condensation of the surgical fundamentals of daily urological practice, written by 33 authors. Well written, referenced, and indexed, it stresses clinical considerations rather than research. The large number of clear anatomical drawings, operative illustrations, and well-chosen x-ray films form an integral part of the didactic presentation. No single volume can be expected to detail every surgical technique or nuance. But very few are missing, and I was pleasantly surprised by the depth and breadth of most chapters. Most chapters are divided into surgical
GI immunology
Authors: Donal Maguire, Gerald O'sullivan
Journal: Gut (1994)

We previously characterised Na+, K+, Clchannels; a Cl-: HCO3-anion ex- changer, a Na+: K+: Cl-cotransporter and a Na+: K+ pump in the sodium absorptive cells of the human colonic epithelium.In this study we examined regulation of K+ recycling which is an important step in Na+ absorption.Hu- man colonic epithelium dissected off freshly resected colectomy specimens was mounted in Ussing chambers.The transepithelial voltage was clamped to 0 mV and the resultant short-circuit current (SCC) recorded.To study the basolateral membrane in isolation, the apical membrane was perforated by the ionophore nystatin (allows bi-directional passage of monovalent cations between the mucosal bath solution and the cytoplasm).A mucosa to serosa K+ gradient was imposed.Since nystatin pores are also permeable to Cl- and Ca2+ ions -these were reduced in the apical bath to 20 mM and 10 nM respectively.Post addition of nystatin, the SCC stabilised at 50-70 sA/cm2.91% of the K+ dependent SCC was inhibited by tolbutamide (100 AM) added to the serosal bath and the remaining basolateral K+ current was inhibited by tetrapentylammonium (TPA) (inhibitors of ATP regulated K+ channels (KATP)
The discovAIR project: a roadmap towards the Human Lung Cell Atlas
Authors: Malte D. Luecken, Laure-Emmanuelle Zaragosi, Elo Madissoon, Lisa Sikkema, Alexandra B. Firsova, Elena De Domenico, Louis Kümmerle, Adem Saglam, Marijn Berg, Aurore C.A. Gay, Janine Schniering, Christoph H. Mayr, Xesús M. Abalo, Ludvig Larsson, Alexandros Sountoulidis, Sarah A. Teichmann, Karen van Eunen, Gerard H. Koppelman, Kourosh Saeb-Parsy, Sylvie Leroy, Pippa Powell, Ugis Sarkans, Wim Timens, Joakim Lundeberg, Maarten van den Berge, Mats Nilsson, Peter Horváth, Jessica Denning, Irene Papatheodorou, Joachim L. Schultze, Herbert B. Schiller, Pascal Barbry, Ilya Petoukhov, Alexander V. Misharin, Ian M. Adcock, Michael von Papen, Fabian J. Theis, Christos Samakovlis, Kerstin B. Meyer, Martijn C. Nawijn
Journal: European Respiratory Journal (2022)

The Human Cell Atlas (HCA) consortium aims to establish an atlas of all organs in the healthy human body at single-cell resolution to increase our understanding of basic biological processes that govern development, physiology and anatomy, and to accelerate diagnosis and treatment of disease. The Lung Biological Network of the HCA aims to generate the Human Lung Cell Atlas as a reference for the cellular repertoire, molecular cell states and phenotypes, and cell–cell interactions that characterise normal lung homeostasis in healthy lung tissue. Such a reference atlas of the healthy human lung will facilitate mapping the changes in the cellular landscape in disease. The discovAIR project is one of six pilot actions for the HCA funded by the European Commission in the context of the H2020 framework programme. discovAIR aims to establish the first draft of an integrated Human Lung Cell Atlas, combining single-cell transcriptional and epigenetic profiling with spatially resolving techniques on matched tissue samples, as well as including a number of chronic and infectious diseases of the lung. The integrated Human Lung Cell Atlas will be available as a resource for the wider respiratory community, including basic and translational scientists, clinical medicine, and the private sector, as well as for patients with lung disease and the interested lay public. We anticipate that the Human Lung Cell Atlas will be the founding stone for a more detailed understanding of the pathogenesis of lung diseases, guiding the design of novel diagnostics and preventive or curative interventions.
THE PREVENTION OF TYPHUS FEVER IN HOSPITAL PERSONNEL
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
JAMA Reference Directories
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Association News
Journal: JAMA (1923)

<h3>THE ACADEMY OF MEDICINE OF ATLANTA, GA.</h3> For many years the Fulton County Medical Society has cherished the ambition to own a home suitably located and of a dignity befitting its purpose. In spite of the financial difficulties involved, the problem was attacked with enthusiasm and the cooperation of virtually every member of the society was secured. The outcome has been the purchase of a spacious building at 32 Howard Street, which has been remodeled to provide an adequate assembly hall, an attractive library, several committee rooms and a number of smaller rooms suitable for offices or living apartments. The name selected is the Academy of Medicine of Atlanta, Georgia. The first meeting in this new home was held Dec. 7, 1922, when Dr. J. Shelton Horsley of Richmond, Va., delivered an address on "The Relation of Biology to Medicine." The dedicatory services took place, December 15, when the hall
Real-World Safety Analysis of Preschool Tree Nut and Sesame Oral Immunotherapy
Authors: Alexandra Baaske, Lianne Soller, Raymond Mak, Tiffany Wong, Victoria Cook, Gregory Rex, Sandy Kapur, Mary McHenry, Joanne Yeung, Scott Cameron, Stephanie Erdle, Edmond Chan
Journal: Journal of Allergy and Clinical Immunology (2022)
Children's exposure to second-hand smoke 10 years on from smoke-free legislation in England: Cotinine data from the Health Survey for England 1998-2018
Authors: Harry Tattan-Birch, Martin J. Jarvis
Journal: The Lancet Regional Health - Europe (2022)

We aimed to investigate trends in children's exposure to second-hand tobacco smoke in England from 1998 to 2018.We used twenty-one years of data from the Health Survey for England, a yearly repeated cross-sectional population study. A total of 49,460 children participated between 1998 and 2018, of whom 17,463 were biochemically confirmed non-smokers aged 4-15. We examined changes in (i) the proportion of children living in reported smoke-free homes and (ii) second-hand smoke uptake, measured quantitatively using saliva cotinine concentration.The percentage of children living in a home reported to be smoke-free increased from 63.0% (95% CI 60.5%-65.2%) in 1998 to 93.3% (91.8%-94.6%) in 2018. This increase was most pronounced among children with a smoker parent, rising from 17.1% (14.7%-19.8%) to 75.9% (70.8%-80.4%). Segmented regression showed that the rate of adoption of smoke-free homes accelerated leading up to the 2007 ban on smoking in public places, growing most rapidly in the four years after its entry into law. Between 1998 and 2018, there was a ten-fold decline in geometric mean cotinine among non-smoking children, from 0.50 ng/ml (0.46-0.56) to 0.05 ng/ml (0.04-0.06). A total of 65.0% (61.2%-68.6%) of children had undetectable cotinine in 2018, up from 14.3% (12.7%-16.0%) in 1998. Children living in rented accommodation were more exposed than those from owner-occupied households, but they experienced similar relative declines across years.Cotinine data show that children's exposure to second-hand smoke has fallen by some 90% since 1998, with an apparent acceleration in adoption of smoke-free homes since the 2007 ban on smoking in public places. A norm has emerged that sees smoking in the home as inappropriate, almost universally where parents are non-smokers, but also increasingly among smoking parents.Public Health England, now the Office for Health Improvement and Disparities, and Cancer Research UK.
Urticaria and/or angioedema events secondary to mRNA COVID-19 vaccinations - Updates from a national case registry
Authors: Sara Anvari, Upeka Samarakoon, Xiaoqing Fu, Jordon Jaggers, Alexei Gonzalez-Estrada, Hey Jin Chong, Sara Van Meerbeke, Andrej Petrov, Linette Milkovich, Elizabeth Harigan, David Khan, Kimberly Blumenthal
Journal: Journal of Allergy and Clinical Immunology (2022)
TSH-TSHR axis promotes tumor immune evasion
Authors: Zhenghao Wu, Zihan Xi, Yunxiao Xiao, Xiangwang Zhao, Jiexiao Li, Nan Feng, Longqing Hu, Renjing Zheng, Ning Zhang, Shuntao Wang, Tao Huang
Journal: Journal for ImmunoTherapy of Cancer (2022)

Background Hormones are identified as key biological variables in tumor immunity. However, previous researches mainly focused on the immune effect of steroid hormones, while the roles that thyroid-stimulating hormone (TSH) played in the antitumor response were far from clear. Methods The source of TSH was determined using single-cell transcriptomic, histologic, quantitative PCR, and ELISA analysis. The influence of TSH on tumor proliferation, invasion, and immune evasion was evaluated in multiple cell lines of thyroid cancer, glioma, and breast cancer. Then transcriptomic sequencing and cellular experiments were used to identify signaling pathways. TSH receptor (TSHR) inhibitor was injected into homograft mouse tumor models with or without anti-programmed cell death protein-1 antibody. Results Monocyte-derived dendritic cells (moDCs) highly expressed TSHα and TSHβ2 and were the primary source of TSH in the tumor microenvironment. TSH released by moDCs promoted proliferation and invasion of tumors with high TSHR expressions, such as thyroid cancers and glioma. TSH also induced tumor programmed death-ligand 1 (PD-L1) expression through the TSHR-AC-PKA-JNK-c-JUN pathway. TSHR inhibitors reversed tumor immune evasion by inhibiting PD-L1 expression in tumor and myeloid cells and enhancing Teff activation. Conclusions TSH–TSHR axis promotes tumor evasion in thyroid cancers and glioma. TSH suppression therapy is an effective therapeutic strategy for combination in immune checkpoint blockades.
MEDICAL NEWS
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reversal of myelofibrosis in Hodgkin disease
Authors: M. V. Viola
Journal: JAMA (1973)

A 31-year-old woman had Hodgkin disease associated with extensive myelofibrosis. Peripheral-blood examination revealed pancytopenia with circulating, immature white blood cells and abnormal red blood cell forms. Following four courses of quadruple chemotherapy the patient had a normal peripheral-blood picture, and a single bone marrow needle biopsy specimen was normal.
Influence of α‐thalassemia trait on spleen function in sickle cell anemia patients with high HbF
Authors: A.D. Adekile, M. Tuli, M.Z. Haider, K. Al‐Zaabi, S. Mohannadi, A. Owunwanne
Journal: American Journal of Hematology (1996)

Spleen function was studied in a group of 20 Kuwaiti SS patients (aged 2–12 years), using 99mTc-labeled tin colloid scintigraphy. They were screened for the α-thalassemia determinants which are prevalent in the Arabian Peninsula [-α (3.7 kb) deletion, α2-globin gene polyadenylation signal (AATAAA → AATAAG) mutation, and 5′ IVS-I splice junction pentanucleotide (GAGGTGAGG → GAGG) deletion] with a combination of polymerase chain reaction and allele-specific oligonucleotide (ASO) hybridization techniques. The patients were divided into three groups depending on the result of their colloid uptake. Group I consisted of 7 patients (35.0%) with normally visualized spleens, Group II consisted of 5 (25.0%) with partial visualization, and in Group III there were 8 (40.0%) in whom the spleen was not visualized at all. The significant distinguishing features among those in Groups I and III were mean corpuscular volumes (MCVs) of 74.1 ± 5.1 and 90.1 ± 6.6 fl (P < 0.0001) and mean corpuscular hemoglobins (MCHs) of 22.4 ± 2.7 and 27.5 ± 4.0 pg (P < 0.05), respectively. The overall frequency of α-thalassemia determinants in the study was 35.0%; however, the frequencies in Groups I, II, and III were 57.1, 30.0, and 18.8%, respectively. α-Thalassemia trait, therefore, appears to be associated with normal splenic function in these patients. © 1996 Wiley-Liss, Inc.
Handbuch der pathogenen Mikroorganismen.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Deaths
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal