tbuckley/cabot-search huggingface dataset:
Abstract 16921: Relationship Between Biomarkers and Different Types of Myocardial Fibrosis in Severe Aortic Valvular Heart Disease
Authors: Lucas J Pires, Vitor E Rosa, THAMARA C MORAIS, Antonio S de Santis, Joao Ricardo C Fernandes, berta p boer, eduardo rossi, Paulo d Lavitola, Carlos E Rochitte, Cesar H Nomura, Pablo M Pomerantzeff, Flavio Tarasoutchi
Journal: Circulation (2020)

Introduction: Aortic stenosis (AS) and aortic regurgitation (AR) patients develop both myocardial hypertrophia and fibrosis. B-type natriuretic peptide (BNP) and troponin are biomarkers whose value in aortic valvular heart disease (VHD) remains controversial. Cardiac magnetic resonance (CMR) imaging can detect replacement myocardial fibrosis (MF) by using late gadolinium enhancement (LGE), and diffuse MF by using extracellular volume (ECV) based measures (relative - ECV fraction - and absolute - indexed ECV) calculated from T1 mapping. Data evaluating the relationship of these biomarkers with both types of MF are scarce in AS, and are missing in AR patients. Hypothesis: There is an association between preoperative BNP and troponin and preoperative MF measures in severe aortic VHD patients. Methods: Patients with isolated severe AS or AR were prospectively recruited to be submitted to CMR before surgery, including LGE and ECV measures quantifications. They also collected blood samples for quantification of BNP and high sensitivity T troponin. The relationship between biomarkers and MF parameters was evaluated using linear regression and nonparametric conventional tests. Results: The study population included 99 patients, 67 with AS and 32 with AR. BNP median was 63 (39-103) pg/mL and troponin median was 17 (5-34) ng/L, no difference between AS and AR (p=0.31 and p=0.88, respectively). BNP and troponin were associated with presence of LGE. BNP median was 47 (32-87) pg/mL without LGE vs. 87 (47-190) pg/mL with LGE (p=0.002). Troponin median was 13 (5-25) ng/L without LGE vs. 30 (10-71) ng/L with LGE (p=0.001). Regarding ECV measures, patients with ECV fraction higher than 28.25% had higher BNP levels (p&lt;0.001) and patients with indexed ECV higher than 24.21mL/m 2 had higher troponin levels (p=0.015) (Figure 1). Conclusions: BNP and troponin are associated with quantity of MF in patients with severe aortic VHD with indication of intervention.
Abstract 13341: Systolic Time Intervals and Alternative Echocardiographic Parameters to Evaluate Bioprosthetic Aortic Valve Function
Authors: Charles Caron, Philippe Pibarot, Anne-sophie Zenses
Journal: Circulation (2020)

Background: Bioprosthesis (BP) used for aortic valve replacement (AVR) in aortic valve disease are subject to structural valve deterioration (SVD) after 20 years or less which leads to reintervention. The diagnostic of SVD can be challenging in the presence of patient-prosthesis mismatch (PPM) which occurs when the effective orifice area (EOA) of the BP is too small for the metabolic needs of a patient. Both SVD and PPM are mainly diagnosed with echocardiography and are characterized by high transprosthetic mean and peak pressure gradients (MG and PG) and maximal velocity (Vmax) as well as reduced EOA. Easily accessible parameters are needed to distinguish SVD from PPM. Acceleration time (AT), ejection time (ET) and AT/ET have been proposed as accurate to identify SVD in presence of PPM. However, these parameters need to be validated. Objectives: The main goal of the present study is to determine the accuracy of AT and AT/ET and to validate new echocardiographic parameters that can distinguish SVD from PPM. New parameters proposed for this study are MG/EOA and PG over mean flow rate (PG/MFR). Methods: In a retrospective study, we analyzed echocardiographic data of 653 patients who underwent AVR. PPM was defined as a projected EOA to body surface area inferior to 0.85 cm 2 /m 2 . SVD was defined using a multiparametric integrative approach including morphological (fibrocalcific remodeling, thickening and stiffening of valve leaflets) criteria and hemodynamic changes according to American Society of Echocardiography/European Association for Cardiovascular Imaging recommendations. Results: EOA was lower and MG higher for patients with SVD compared to those with pure PPM. PG/Q and MG/EOA were significantly higher in patients with SVD compared to patients presenting pure PPM (PG/MFR: 0.22 mm Hg/ml/s ± 0.01 vs 0.15 mm Hg/ml/s ± 0.01; MG/EOA: 31 mm Hg/cm 2 ±2 vs 16 mm Hg/cm 2 ±2, p&lt;0.001) respectively. ROC analysis showed that PG/Q and MG/EOA were the best echocardiographic parameters to distinguish pure PPM from SVD with AUC of 0.872 and 0.876 respectively. AT and AT/ET achieved AUC of 0.682 and 0.663. Conclusion: AT and AT/ET are not accurate parameters to identify SVD in presence of PPM. MG/EOA and PG/MFR represent interesting alternatives to conventional parameters.
内因性CaMKII必要の速度論光遺伝学的キナーゼ阻害剤により明らかにされたシナプス可塑性【Powered by NICT】
Authors: Murakoshi Hideji, Shin Myung Eun, Parra-Bueno Paula, M Szatmari Erzsebet, C E Shibata Akihiro, Yasuda Ryohei
Journal: Neuron (2017)
Abstract 057: Beyond Convenience: Video Visits Can Increase The Efficiency Of Preventive Care Delivery
Authors: Neil M Kalwani, Katherine M Wang, Jahnavi Deb, Thomas Gold, Akhil Maddukuri, Emily Savage, David Scheinker, Rajesh Dash, Fatima Rodriguez
Journal: Circulation (2021)

Introduction: In response to the COVID-19 pandemic, medical practices have expanded utilization of telehealth. Little is known about the operational impacts of transitioning from in-person to video visits in specialty clinics. In 2018, the Stanford South Asian Translational Heart Initiative (SSATHI), a preventive cardiology clinic focused on high-risk South Asian adults, introduced CardioClick, a program replacing in-person follow-up visits with video visits. Hypothesis: We hypothesized that implementation of video visits increased the efficiency of clinic operations. Methods: We extracted visit-level data from the EHR for 134 patients enrolled in CardioClick with video follow-up visits from June 14, 2018 to April 21, 2020 and a cohort of 276 patients enrolled in the in-person SSATHI prevention program with follow-up visits from September 11, 2014 to March 6, 2020. Results: Patients in CardioClick and the in-person cohort were similar in terms of age (mean 45 years), gender balance (23 vs 21% female), and cardiometabolic risk profiles. There were 181 video and 637 in-person follow-up visits. Video visits were shorter than in-person visits, both in terms of total clinic time [median 22 min (IQR 16, 29) vs 67 min (48, 100)] and provider time required [median 22 min (IQR 16, 29) vs 30 min (12, 58)]. Video visits were more likely to end on time (71 vs 11%, p&lt;0.001). The median video visit ended on time while the median in-person visit ended 32 min late (13, 70) (see Figure). Providers were also more likely to complete video visit documentation the same day (56 vs 42%, p=0.001). Conclusions: In a preventive cardiology clinic, video follow-up visits required less clinic and provider time than in-person visits, were more likely to end on time, and were associated with increased same-day provider documentation completion. In conclusion, video visits offer benefits beyond their convenience and may increase the operational efficiency of specialty care practices focused on disease prevention, improving value in care delivery.
Allogeneic Haematopoietic Cell Transplantation in Aplastic Anaemia: A Dataset of 240 Cases
Authors: Parvez Ahmed, Tariq Mahmood Satti, Qamar Un Nisa Chaudhry, Syed Kamran Mahmood, Humayoon Shafique Satti, Tariq Ghafoor, Nighat Shahbaz, Mehreen Ali Khan, Raheel Iftikhar
Journal: Blood (2017)
Targeting the Epigenetic and Metabolic Vulnerabilities of Ezh2-Deficiency-Induced Myeloid Neoplasms
Authors: Zhimin Gu, Yuxuan Liu, Hui Cao, Mingyi Chen, Yuannyu Zhang, Le Qi, Xin Liu, Kailong Li, Kathryn Dickerson, Feng Cai, Weina Chen, Min Ni, Ralph Deberardinis, Jian Xu
Journal: Blood (2017)
Abstract 16235: Rhythmic Disturbances in Patients With Cardiac Amyloidosis: Analysis From Cedars-Sinai Amyloidosis Registry
Authors: Jae Hyung Cho, Natasha Cuk, Derek Leong, Ashkan Ehdaie, Eugenio Cingolani, Michael Shehata, Jignesh Patel
Journal: Circulation (2020)

Introduction: Cardiac arrhythmias are frequent complications of patients with cardiac amyloidosis. The burden and nature of cardiac arrhythmias in patients with cardiac amyloidosis have not been investigated in a large patient population. Hypothesis: Cardiac amyloidosis is a highly arrhythmogenic disorder requiring implantation of cardiac electronic devices. Methods: Cedars-Sinai amyloidosis registry was analyzed to investigate the prevalence and nature of cardiac arrhythmias in patients with cardiac amyloidosis. Ambulatory ECG monitoring data, implantable cardioverter-defibrillator or pacemaker implantation, and interrogation data were reviewed to study the burden of cardiac arrhythmias in patients with cardiac amyloidosis. Results: A total of 156 patients were analyzed in the registry: 51 patients (32.7%) with AL amyloidosis, 101 patients (64.7%) with ATTR amyloidosis, and 4 patients with AA amyloidosis (2.6%). Thirty-seven patients (23.7%) were implanted with cardioverter-defibrillator; 23 patients (14.7%) for primary prevention, 11 patients (7.1%) for secondary prevention of ventricular tachycardia, and 3 patients (1.9%) for secondary prevention of ventricular fibrillation. Twenty-two patients (12.1%) needed pacemaker implantation; 9 patients (5.8%) for high-grade or complete heart block, and 13 patients (8.3%) due to sick sinus syndrome. The most common arrhythmias were atrial fibrillation occurring in 80 patients (51.3%) followed by first-degree AV block in 31 patients (19.9%). Sustained ventricular tachycardia occurred in 14 patients (8.9%) during hospitalization, device interrogation or ambulatory monitoring. Conclusions: Both atrial and ventricular arrhythmias are common manifestations of cardiac amyloidosis, frequently necessitating implantation of cardiac electronic devices.
Abstract 14838: Diagnostic Referral Biases Affect Black and Female Patients With Severe Aortic Stenosis
Authors: John P Skendelas, Joseph J DeRose, Daniel J Goldstein, Stephen J Forest
Journal: Circulation (2020)

Introduction: The role of racial and socioeconomic factors, using the novel distressed communities index (DCI), on referral patterns in patients with severe aortic stenosis (AS) is poorly characterized. Hypothesis: Non-White patients are less likely to be referred for possible aortic valve intervention (AVI). Methods: Between January 1, 2010 and December 31, 2019 all adult patients with evidence of severe AS on echocardiogram were identified. Patients with prior aortic valve replacement were excluded. Referral and non-referral were determined in the electronic medical record (EMR) up to 14 days after index echocardiogram. In absence of referral, patients who died within 14 days were excluded. All patients were included in a multivariate logistic regression model of non-referral to adjust for statistically significant differences in age, sex, pre-existing medical comorbidities, DCI score, and AS hemodynamics. Results: Of the 179,483 patients identified, 1535 met inclusion criteria for the study. The overall mean age was 80.2 years (95% CI [79.6-80.8]) and was composed of White/Caucasian (50.7%), Black/African American (17.9%), Hispanic/Latino (26.1%), Asian (2.8%), and majority female (58.5%) patients. Female (OR 1.442, 95% CI [1.113-1.866] and Black (OR 1.468, 95% CI [1.023-2.106]) patients faced referral disparities, in spite of adjustment for advanced age (OR 3.739, 95% CI [2.556-5.470]) and dementia (OR 3.114, 95% CI [2.053-4.722]). Pre-existing stroke was collinear with dementia and excluded. In contrast, patients with history of coronary artery disease and those who were evaluated after initiation of the electronic medical record were more likely to be referred. Conclusions: When adjusted for medical comorbidities and socioeconomic factors, Black and female patients were less likely to be referred for possible AVI. Additional studies are required to characterize disparities at other levels of healthcare utilization.
Abstract P130: Association Between Ready-to-eat Cereal Consumption And Nutrient Intakes Among Children 2 To 18 Years, Stratified By Household Income: Results From The National Health And Nutrition Examination Survey 2015-2018
Authors: Jessica Smith, Neha Jain, James Normington, Norton Holschuh, Yong Zhu
Journal: Circulation (2021)

Ready-to-eat (RTE) cereal has been associated with higher diet quality and dairy intake (it is often consumed with milk) in children and is an affordable source of under-consumed nutrients and whole grains. Because of its affordability and accessibility, the contribution of RTE cereal to nutrient and whole grain intake could potentially differ by household income level. We hypothesized that children living in low income households, which may be more susceptible to poor dietary intakes due to food insecurity, may differentially benefit, in terms of nutrient intake, from RTE cereal consumption compared to children in higher income households. The objective of this study was to quantify the nutrient intakes of U.S. children who reported consuming RTE cereal eater versus those that did not according to household income. We used data from the 2015-2016 and 2017-2018 National Health and Nutrition Examination Survey, a nationally representative, cross-sectional survey. Children 2 to 18 years (n=5,028) were stratified into six groups according to RTE cereal consumption (cereal eaters vs non-eaters) and poverty-to-income ratio (PIR; low-, mid-, and high-income). We calculated the difference in intakes of 28 nutrients between cereal eaters and non-eaters stratified by PIR. Overall, it appeared that there was a greater difference in intake of nutrients between RTE cereal eaters and non-eaters for the low-income compared to the high-income children. For example, in the low-income group, RTE cereal eaters had 23% higher calcium, 70% higher iron, and 90% higher vitamin D intake compared to non-RTE cereal eaters (p&lt;0.0001 for all). In the high-income group, these differences were attenuated with cereal eaters having 12% higher calcium (p=0.03), 58% higher iron (p&lt;0.0001), and 62% higher vitamin D intake (p&lt;0.0001) compared to non-RTE cereal eaters. These data suggest that although cereal eaters had higher intake of under-consumed nutrients across all incomes, children in the low-income group particularly benefited.
Macrophage-mediated tumor homing of hyaluronic acid nanogels loaded with polypyrrole and anticancer drug for targeted combinational photothermo-chemotherapy
Authors: Tingting Xiao, Wei Hu, Yu Fan, Mingwu Shen, Xiangyang Shi
Journal: Theranostics (2021)

Development of nanosystems that can be integrated with macrophages (MAs), an emerging carrier system, for effective tumor therapy remains to be challenging. We report here the development of MAs specifically loaded with hyaluronic acid (HA) nanogels (NGs) encapsulated with a photothermal agent of polypyrrole (PPy) and anticancer drug doxorubicin (DOX) (HA/DOX@PPy NGs) for tumor homing and combination photothermo-chemotherapy.
Assessment of the FilmArray ME panel in 4199 consecutively tested cerebrospinal fluid samples
Authors: Johan Lindström, Kristina Elfving, Magnus Lindh, Johan Westin, Marie Studahl
Journal: Clinical Microbiology and Infection (2021)

In central nervous system infections, early and correct management is of utmost importance. Rapid syndromic panel testing can potentially provide valuable guidance. The FilmArray meningitis/encephalitis (ME) panel detects 14 pathogens through multiplex PCR. Our study objectives were to assess its performance compared with established diagnostic procedures, especially real-time quantitative PCR for detection of viruses, and to determine the diagnostic and clinical significance of discrepant results.All cerebrospinal fluid samples sent for viral diagnostics to our microbiological laboratory over 34 months were analysed with the ME panel and in-house real-time PCR for herpes simplex virus type 1 (HSV-1), HSV-2, varicella zoster virus and enteroviruses. Other pathogens detected by the panel were confirmed by routine diagnostic procedures. Discrepant results were analysed through interpretation of biological and clinical data, and performance data were calculated for individual pathogens.Altogether, 315 pathogens were detected by the ME panel in 4199 cerebrospinal fluid samples (7.5%) and an additional 21 viral targets were identified using real-time PCR. Thirty-four ME panel detections were not confirmed, totalling 55 discrepant results. After discrepancy analysis, 20 false-positive and 21 false-negative ME panel results remained. Performance varied between pathogens. Sensitivity for HSV-1 was calculated at 82.4% (59.0%-93.8%) with three false-negative results. Also noteworthy were 13 false-negative enterovirus and eight false-positive Streptococcus pneumoniae results.Our analysis shows good performance for the ME panel in diagnosing central nervous system infection. The risk of false-negative HSV-1 results, however, warrants additional testing when encephalitis is suspected. Uncertainties in interpretation of enterovirus and S. pneumoniae results represent other limitations.
Abstract 060: Cardiovascular Disease Burden In A Psychiatric Outpatient Population
Authors: Radha Dhingra, Fan He, Erika F Saunders, Daniel A Waschbusch, Amanda M Pearl, Dahlia Mukherjee, Edward O Bixler, Jody L Greaney, Duanping Liao
Journal: Circulation (2021)

Objective: To understand the burden of cardiovascular diseases (CVDs) in a psychiatric outpatient population. Methods: We used baseline data from the ongoing Penn State Psychiatry Clinical Assessment and Rating Evaluation System (PCARES) Registry, which is comprised of adult patients who were seen at a psychiatric outpatient clinic affiliated with the Department of Psychiatry and Behavioral Health and the Penn State Milton S. Hershey Medical Center. The Electronic Medical Record (EMR) data from 3,024 patients who sought psychiatric care between 02/17/2015 and 09/18/2019 were included in this report. We compared the prevalence of CVDs and the mean levels of major CVD risk factors in our sample with that reported in the 2013-2016 National Health and Nutrition Examination Survey (NHANES). Results: The mean age of the study population was 42.7 (16.7) years, with 63% female and 85% Caucasians. The most common psychiatric diagnoses at baseline were Major Depressive Disorder [ICD-10: F32 &amp; F33] (45%), Generalized Anxiety Disorder [ICD-10: F41.1] (20%), and Bipolar Disorder [ICD-10: F31] (12%). Eighteen percent of patients reported using tobacco products and 1.7% reported using alcohol. The prevalence (%) of CVDs, type 2 diabetes, hypertension, and dyslipidemia in our sample were 9.1, 20, 48, and 41%, respectively (all significantly higher than the NHANES reports, all p &lt; 0.0001). The baseline means (mg/dl) of total cholesterol (C), LDL-C, HDL-C, and triglycerides (TG) were 186, 108, 48, and 156, respectively (all are significantly lower than that reported from the NHANES, except for TG, which was higher than that of the NHANES, all p &lt; 0.0001), while 22% of all patients had prescriptions for lipid-lowering medications. Baseline mean level of glucose and HbA1C were 111 mg/dl and 6.2% (both significantly higher than that from the NHANES, p &lt; 0.0001). Conclusions: In this systematic registry of psychiatric outpatients from a mid-Atlantic academic medical center, the baseline CVD burden as measured by common cardiovascular diseases, comorbidities and risk factors are significantly higher than the CVD burden in the general US population. Considering that the mean age of this patient population is 5 years younger than that of the NHANES population, our data underscores the need for control and prevention of CVD in patients with psychiatric conditions, and suggests the potential of integrating mental and physical health care in this type of special population.
Abstract 16927: Cardiovascular Magnetic Resonance Stress Perfusion Imaging Predicts One Year Outcomes Following Equivocal or Uncertain Stress Study
Authors: Arun Iyer, Michael Tao, Erik B Schelbert, Timothy C Wong
Journal: Circulation (2020)

Introduction: Patients with equivocal nuclear stress test (SPECT) results are at higher risk for cardiac events compared to those with normal studies. Cardiovascular magnetic resonance stress perfusion imaging (SCMR) identifies individuals with coronary artery disease (CAD) with high sensitivity and specificity, with excellent spatial resolution, and without ionizing radiation. The utility of SCMR testing is uncertain in individuals with prior equivocal stress results. Hypothesis: SCMR provides high prognostic capability to risk stratify patients after equivocal or uncertain SPECT studies. Methods: We retrospectively analyzed patients from 2011 to 2019 with equivocal or uncertain SPECT studies subsequently referred for SCMR within a 6 month window. Equivocal studies included qualifying wording such as significant artifact or technical difficulty. Uncertain studies included documented suspicion of false positive or false negative results. Adverse outcomes were defined as cardiovascular death or obstructive CAD found on unplanned coronary angiography (CA). Results: 151 patients met inclusion criteria: mean age 58, male 88 (58%). At one year, the negative predictive value of SCMR was 0.97; 122 patients with negative SCMR had a total of 4 events including 1 cardiovascular death and 3 obstructive CAD on CA. 27 patients had positive SCMR for ischemia, of which 9 patients were referred for CA and all demonstrated obstructive CAD. 18 patients were medically managed without adverse events. 2 patients were noted to have non-diagnostic SCMR and subsequent CA showed no significant CAD. Conclusion: Following equivocal or uncertain SPECT, SCMR demonstrated high 1-year prognostic capability with negative predictive value of 0.97 for adverse outcomes and high positive predictive value for obstructive CAD. SCMR may represent a reasonable, noninvasive option should additional risk stratification be required in this clinical setting.