tbuckley/cabot-search huggingface dataset:
Private outpatient consultations in the NHS--where do we stand?
Journal: BMJ (1978)

In October 1977 the Health Services Board reported that it intended to withdraw certain authorisations for the use of NHS accommodation and services by private patients (Cmnd 6963).These included the use of consulting rooms at particular hospitals where it had been "established beyond doubt" (though not always correctly) that the facilities had not been used in 1975 or 1976.In some cases consultants had used accommodation under rental agreements not covered by Section 66* of the 1977 NHS Act.But in November 1977 the DHSS decided that health authorities should be advised not to make any new arrangements for leasing, renting, or licensing hospital accommodation to consultants for private con- sultations, or to renew existing arrangements.The Joint Consultants Committee main- tained that this deCision could mean health authorities refusing to renew a rental agree- ment for a consulting room or similar accom- modation earlier than would have been recom- mended by the board on the basis of usage, demand, and/or availability of alternative facilities.The DHSS accepted this and agreed that a rental agreement should not be ended without consultation with the Health Services Board, taking account of the principles of Section 70t of the 1977 Act.Even so, the Department still intended to advise authori- ties not to make new agreements or to extend any existing ones to newly appointed con- sultants if Section 66 facilities co-existed at the hospital.The JCC rejected this proposal
Leg-lengthening
Authors: F. G. Allan
Journal: BMJ (1951)

SUBACUTE BACTERIAL ENDOCARDITIS JBRJouaNo growth occurred in ordinary media or media enriched with glucose, starch, human serum, human plasma, or horse plasma, or on Loeffler's inspissated serum.As growth had been obtained only in the presence of blood, the organism was assigned provisionally to the Haemoph.lus group and the growth requirements were investigated in some detail.On "chocolate blood agar" (heated to 80' C.) growth was slower and weaker than on blood agar; no growth occurred on autoclaved blood agar.On the other hand, the organism grew on ordinary agar around colonies of staphylococci, and in broth to which staphylococcus filtrate was added; abundant growth took place in media containing 10% yeast extract.Thus the organism required the presence of the V or co-enzyme factor, and was independent of the X or haematin factor.It was therefore identified as a non-haemolytic H. para-influenzae (Valentine and Rivers, 1927).Fermentation tests were carried out in peptone water with 100% yeast extract-prepared according to the method of Miles and Gray (1938)-which by itself does not srlit saccharose or maltose.The organism grew well in this medium and produced acid, without gas, from glucose, saccharose, and maltose, but not from lactose, mannitol, or dulcitol.No change occurred in litmus milk, and indole was not produced.This organism died out on agar plates in 48-72 hours but survived for 11 weeks in blood-culture bottles which.after five days' incubation at 370 C., were left at room temperature.It survived heating to 56' C. for five minutes, but not for 10 minutes.The organism was completely resistant to penicillin (10 units per ml.), was highly sensitive to streptomycin in the " ditch test," and in fluid media growth was inhibited by 1.6 yg. of streptomycin per ml. of medium.On May 22 the patient's serum was tested for antibodies.Miles -and Gray (1938) reported agglutination of H. para- influenzae by their patient s serum to a titre of 1 in 90, but stressed the difficulty of preparing a stable suspension of the organism.The same difficulty, due to roughness of the colonies, was experienced with our strain.Unsuccessful attempts were made to emulsify colonies in saline by raising the pH to 8.2.Fine susne-sions of organisms or fragmented
Association of History of Spontaneous or Induced Abortion With Subsequent Risk of Gestational Diabetes
Authors: Yan Zhao, Yongbo Zhao, Kechen Fan, Liping Jin
Journal: JAMA Network Open (2022)

<h3>Importance</h3> Gestational diabetes (GD) is one of the most common and important complications of pregnancy. Identifying pregnant women who are at high risk of GD is crucial for implementing early prevention and intervention. <h3>Objective</h3> To examine whether a history of spontaneous abortion (SAB) or induced abortion is associated with increased risk of GD in subsequent pregnancies. <h3>Design, Setting, and Participants</h3> This retrospective cohort study was conducted at a tertiary hospital in Shanghai, China. Pregnant women who received routine antenatal care between January 2014 and December 2019 were included. Data analysis was performed from December 2020 to June 2021. <h3>Exposures</h3> Maternal history of abortion, including SAB and induced abortion, were extracted from medical records. <h3>Main Outcomes and Measures</h3> GD was diagnosed with a 75-g diagnostic oral glucose tolerance test. A multivariable-adjusted log-binomial analysis was used to estimate relative risks (RRs) and 95% CIs of GD associated with history of abortion. <h3>Results</h3> Among the 102 259 included pregnant women (mean [SD] age, 29.8 [3.8] years), 14 579 (14.3%) experienced only SAB, 17 935 (17.5%) experienced only induced abortion, and 4017 (3.9%) experienced both SAB and induced abortion. A total of 12 153 GD cases were identified, and the prevalence of GD was 11.9% (12 153 of 102 259 women) in this cohort. Pregnant women who experienced only SAB (RR, 1.25; 95% CI, 1.18-1.31) or both SAB and induced abortion (RR, 1.15; 95% CI, 1.05-1.27) were at higher risk of developing GD. The association of SAB history with GD occurred in a number-dependent manner. Compared with pregnant women with no history of abortion, the RR for GD increased by 18% (RR, 1.18; 95% CI, 1.11-1.26) for pregnant women with 1 SAB, by 41% (RR, 1.41; 95% CI, 1.27-1.57) for those with 2 SABs, and by 43% (RR, 1.43; 95% CI, 1.22-1.67) for those more than 2 SABs. However, no association between history of induced abortion and GD was observed. <h3>Conclusions and Relevance</h3> This study found that a history of SAB was associated with increased risk of GD in subsequent pregnancies. Further research is needed to clarify this association and explore the potential biological mechanisms underlying the association.
ON THE SEROLOGICAL SPECIFICITY OF PEPTIDES. III
Authors: K. Landsteiner, J. van der Scheer
Journal: The Journal of Experimental Medicine (1939)

Experiments are described dealing with immune sera to pentapeptides and peptide amides. Absorption and inhibition tests gave no indication of the presence in the immune sera of special antibodies for portions of a peptide molecule but the antibodies appeared to be specific for an entire pentapeptide even though the sera contained qualitatively different fractions. Marked disparity was found between the reactions of peptides and corresponding amides indicating differences between acid and other polar groups in their influence on serological specificity.
Strategies to overcome the main challenges of the use of CRISPR/Cas9 as a replacement for cancer therapy
Authors: Mohammed Fatih Rasul, Bashdar Mahmud Hussen, Abbas Salihi, Bnar Saleh Ismael, Paywast Jamal Jalal, Anna Zanichelli, Elena Jamali, Aria Baniahmad, Soudeh Ghafouri-Fard, Abbas Basiri, Mohammad Taheri
Journal: Molecular Cancer (2022)

Abstract CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats-associated protein 9) shows the opportunity to treat a diverse array of untreated various genetic and complicated disorders. Therapeutic genome editing processes that target disease-causing genes or mutant genes have been greatly accelerated in recent years as a consequence of improvements in sequence-specific nuclease technology. However, the therapeutic promise of genome editing has yet to be explored entirely, many challenges persist that increase the risk of further mutations. Here, we highlighted the main challenges facing CRISPR/Cas9-based treatments and proposed strategies to overcome these limitations, for further enhancing this revolutionary novel therapeutics to improve long-term treatment outcome human health.
Effects of metformin and lutheinizing hormone receptor agonists on steroidogenesis and spermatogenesis in rats with type 2 diabetes with their separate and combined administration
Authors: A.A. Bakhtyukov, K.V. Derkach, A.M. Stepochkina, V.N. Sorokoumov, L.V. Bayunova, I.A. Lebedev, A.O. Shpakov
Journal: Metabolism (2022)
Insulin resistance and miR-143/miR-145 relative expression profile is associated with dysregulation in the pathological adiposity setting in aging
Authors: Jesús-Aureliano Robles-De Anda, Fernanda-Isadora Corona-Meraz, Perla-Monserrat Madrigal-Ruíz, Jorge Castro-Albarran, Miltón-Omar Guzman-Ornelas, Jaqueline-Alejandra Noboa-Velasteguic, Ana-Lilia Fletes-Rayas, Rosa-Elena Navarro-Hernández
Journal: Metabolism (2022)
ABC of Asthma: Asthma in children: treatment
Journal: BMJ (1984)

Diseases (Scotland) Unit was set up in 1977, and in that year detected 15 infections.The numbers doubled each subsequent year,3 and in 1982 reached 1033 reported infections (table II), including 519 indigenous infections (half of the total) in which the consort was also infected in Britain: 154 of these indigenous infections were contracted in Greater London, 30 in Birmingham, 28 in Liverpool, 20 in Bristol, 18 in Leeds, and fewer cases in other areas.
Sports Medicine
Authors: Jack B. Ryan
Journal: JAMA (1992)

Sports medicine combines nonsurgical and surgical subspecialties that deal with the health care issues of athletes (young or old, competitive or recreational, professional or amateur, and healthy or injured). This update reviews the recent advances in the care of the female athlete, the drug problem in sports, new techniques of knee rehabilitation, and treatment of meniscus tears. Engstrom et al<sup>1</sup>noted that 41 elite female soccer players experienced a higher rate of injuries (12 per 1000 hours of exposure) than a comparable group of male soccer players (five per 1000 hours). Approximately one in six of these female players sustained a major knee ligament or meniscus tear. Ireland and Wall<sup>2</sup>investigated Olympic trial basketball players and found a higher incidence of knee injuries among women (34 of 64) than among men (11 of 80). The severity and requirement for surgery were also statistically higher. These studies indicate the
5. Testing for Replication Competent Lentivirus Associated with HIV1 Lentiviral Vectors
Journal: Molecular Therapy (2003)

CONSIDERATIONStransduced.Ten years after the last cell infusion, real-time PCR analysis for the presence of vector sequences in these patients revealed that ∼18% of peripheral blood mononuclear cells (PBMCs) from patient 1 carried the vector, whereas <0.1% of LASN-marked PBMCs were detectable in the second patient.Although no serious adverse events have been observed in either patient, the recent events of insertional oncogenesis in X-linked severe combined immunodeficiency patients treated with retroviral-mediated gene transfer prompted us to study the integration sites in lymphocytes from our patients with the aim of mapping the regions involved by the retroviral integration events, determining their localization with respect to known genes, and assessing whether recurrent patterns could be identified.Genomic DNA was prepared from stored PBMCs samples dating 1991, 1992, 1995, and 1996 and from 9 lymphocytic single cell clones established in 1998.Using the "inverse PCR" technique (Nolta et al.PNAS 1996; 93: 2414) we isolated ∼105 integration sites from bulk PBMC samples and ∼20 integration sites from single cell clones.To date, 34 of these sequences have subjected to detailed analysis.We used MegaBLAST (http:// www.ncbi.nlm.nih.gov/blast/megablast.html) to compare the sequences to the Nov 2002 (build 31) assembly of the human genome and identified eleven sequences that mapped to a unique position in the human genome.The positions of 15,000 known genes have been determined by aligning mRNA Reference Sequences to the human genome (genome.ucsc.edu).We determined whether any of the eleven integration sites occurred within 10 kb of one of these known genes.We found one sequence within an intron of the androgen induced protein (AIG-1) gene, one sequence within an intron of the ubiquitinconjugating enzyme E2L 3 (UBE2L3) gene, and one sequence 9 kb upstream of interleukin 1 receptor antagonist (IL1RN) gene.The remaining sequences mapped >10 kb from known genes or did not return significant similarities.Overall, our results indicate that this technique can be used to map retroviral integration sites both from bulk PBMC populations as well as single cell clones.In addition, this preliminary analysis would suggest that the integration events of the LASN vector largely did not occur within the coding regions of genes.Finally, one integration site isolated from the 1996 bulk PBMC sample was recovered also from two of the single cell clones generated 2 years later, thus demonstrating that this approach can be applied to tracking and longevity studies.
Erratum. 2022 National Standards for Diabetes Self-Management Education and Support. Diabetes Care 2022;45:484–494
Authors: Jody Davis, Amy Hess Fischl, Joni Beck, Lillian Browning, Amy Carter, Jo Ellen Condon, Michelle Dennison, Terri Francis, Peter J. Hughes, Stephen Jaime, Ka Hei Karen Lau, Teresa McArthur, Karen McAvoy, Michelle Magee, Olivia Newby, Stephen W. Ponder, Uzma Quraishi, Kelly Rawlings, Julia Socke, Michelle Stancil, Sacha Uelmen, Suzanne Villalobos
Journal: Diabetes Care (2022)
Book Listings
Journal: Annals of Internal Medicine (2002)

Book Listings20 August 2002Book ListingsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-4-200208200-00032 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail CardiologyAlcohol and Heart DiseaseR Watson and AK Myers, eds. 261 pages. Philadelphia: Taylor & Francis; 2002. $80.00. ISBN 0415273471. Order phone 800-821-8312.Beta-Blockers in Heart FailureJ McMurray and MJ Kendall. 108 pages. Philadelphia: Taylor & Francis; 2002. $15.00. ISBN 1853179027. Order phone 800-821-8312.Blackwell's Primary Care Essentials: CardiologyJ Sutherland. 304 pages. Cambridge, MA: Blackwell Science; 2001. $40.00. ISBN 0632044756. Order phone 800-759-6102.Cardiac Arrythmias: Practical Notes on Interpretation and Treatment6th edition. DH Bennett. 340 pages. Boston: Arnold; 2002. $30.00. ISBN 0340807318. Order phone 800-759-6102.Cardiogenic Shock: Diagnosis and TreatmentD Hasdai, PB Berger, A Battler, and DR Holmes Jr, eds. ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 August 2002Volume 137, Issue 4Page: B1 ePublished: 20 August 2002 Issue Published: 20 August 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.Loading ...
Characterization of distinct circular RNA signatures in solid tumors
Authors: Chengdi Wang, Wen-Rong Liu, Shuangyan Tan, Jian-Kang Zhou, Xiaomin Xu, Yue Ming, Jian Cheng, Jiao Li, Zhen Zeng, Yuanli Zuo, Juan He, Yong Peng, Weimin Li
Journal: Molecular Cancer (2022)

Abstract Background Circular RNAs (circRNAs) are differentially expressed between normal and cancerous tissues, contributing to tumor initiation and progression. However, comprehensive landscape of dysregulated circRNAs across cancer types remains unclear. Methods In this study, we conducted Ribo-Zero transcriptome sequencing on tumor tissues and their adjacent normal samples including glioblastoma, esophageal squamous cell carcinoma, lung adenocarcinoma, thyroid cancer, colorectal cancer, gastric cancer and hepatocellular carcinoma. CIRCexplorer2 was employed to identify circRNAs and dysregulated circRNAs and genes were determined by DESeq2 package. The expression of hsa_circ_0072309 (circLIFR) was measured by reverse transcription and quantitative real-time PCR, and its effect on cell migration was examined by Transwell and wound healing assays. The role of circLIFR in tumor metastasis was evaluated via mouse models of tail-vein injection and spleen injection for lung and liver metastasis, respectively. Results Distinct circRNA expression signatures were identified among seven types of solid tumors, and the dysregulated circRNAs exhibited cancer-specific expression or shared common expression signatures across cancers. Bioinformatics analyses indicated that aberrant expression of host genes and/or RNA-binding proteins contributed to circRNA dysregulation in cancer. Finally, circLIFR was experimentally validated to be downregulated in six solid tumors and to significantly inhibit cell migration in vitro and tumor metastasis in vivo. Conclusions Our results provide a comprehensive landscape of differentially expressed circRNAs in solid tumors and highlight that circRNAs are extensively involved in cancer pathogenesis.
Correction: Functional <i>Ex Vivo</i> Assay Reveals Homologous Recombination Deficiency in Breast Cancer Beyond BRCA Gene Defects
Authors: Titia G. Meijer, Nicole S. Verkaik, Anieta M. Sieuwerts, Job van Riet, Kishan A.T. Naipal, Carolien H.M. van Deurzen, Michael A. den Bakker, Hein F.B.M. Sleddens, Hendrikus-Jan Dubbink, T. Dorine den Toom, Winand N.M. Dinjens, Esther Lips, Petra M. Nederlof, Marcel Smid, Harmen J.G. van de Werken, Roland Kanaar, John W.M. Martens, Agnes Jager, Dik C. van Gent
Journal: Clinical Cancer Research (2019)
Epipodophyllotoxin VP 16213 in Treatment of Acute Leukaemia--Haematosarcoma and Solid Tumours
Journal: BMJ (1973)

Epipodophyllotoxin VP 16213 (4-demethyl-epipodophyllotoxin-β-D-ethylidene glucoside), given to 250 patients with various types of malignant disease, induced apparently complete remissions in four out of eight cases of acute monocytoid and acute myelomonocytoid leukaemia but only one complete regression and six incomplete remissions in 21 cases of reticulosarcoma. Incomplete regressions occurred in patients with Hodgkin9s disease, lymphosarcoma, melanoma, and carcinoma of the breast, ovary, testis, bladder, kidney, and thyroid. Seemingly complete regressions of malignant pleural effusion occurred when the drug was given systemically. Toxic side effects interfered with treatment in 40 patients but stopped it in only nine. No signs of toxicity were seen in 114 patients and in 85 the side effects were negligible. VP 16213 represents an advance in the treatment of acute monocytoid leukaemia, which has been up till now insensitive to any drug.
Antiserum for Rabies, or Pasteur Revisited
Authors: J. R. E.
Journal: Annals of Internal Medicine (1963)

Editorials1 May 1963Antiserum for Rabies, or Pasteur RevisitedJ. R. E.J. R. E.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-5-899 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOne of the great stories in medicine is that of Pasteur's discovery of the vaccine treatment of rabies. As told in his biography by his son-in-law (1), the first treatment in 1885 of little Joseph Meister from Alsace is one of the moments of high suspense in medical history. As the time approached for the final and twelfth injection of the new vaccine, Pasteur was haggard and sleepless with worry: would the little boy contract the dread disease—from his vaccine or in spite of it? As all the world knows, little Joseph remained well and happy and lived to be...References1. VALLERY-RADOT R: Life of Pasteur, Constable and Company, Ltd., London, 1911. Google Scholar2. Expert Committee on Rabies, fourth report. WHO Techn. Rep. Ser. no. 201, 1960. Google Scholar3. Annual report. Pennsylvania Department of Health, Harrisburg, 1961. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPrevention of Rabies 1 May 1963Volume 58, Issue 5Page: 899-900KeywordsRabiesVaccines ePublished: 1 December 2008 Issue Published: 1 May 1963 PDF downloadLoading ...
Continuous Glucose Monitoring and Glycemic Control in People With Type 2 Diabetes: Real-World Study
Authors: Alondra Nicole Maldonado Reyes, Arely Joseline Lugo de la Cruz, Cecilia Nohemí Ramírez Frias, Martha Evelyn Mirafuentes Ríos, Eliud Salvador Aguilar Barrera
Journal: Metabolism (2022)
Five-year findings of the hypertension detection and follow-up program. III. Reduction in stroke incidence among persons with high blood pressure. Hypertension Detection and Follow-up Program Cooperative Group
Journal: JAMA (1982)

The Hypertension Detection and Follow-up Program (HDFP) previously reported a 16.9% reduction in all-cause mortality among its Stepped Care (SC) group, relative to the community-treated Referred Care (RC) group. The current report compares cerebrovascular disease (CV) morbidity and mortality in the SC and RC populations. The SC five-year stroke incidence (1.9 per 100 persons) is significantly lower than that found among the RC (2.9 per 100 persons). Reductions in stroke rates among SC were experienced for all race-sex groups, all diastolic blood pressure strata, all ages, and among those with or without evidence of long-standing hypertension. Comparisons of the CV death rates for SC (1.06 per 1,000 persons) and RC (1.91 per 1,000 persons) with those obtained for the general US population (0.83 per 1,000 persons) indicate that the CV death rate decreased in the SC hypertensive population to a level approaching that of the general US population.