tbuckley/cabot-search huggingface dataset:
The Management of Type 1 Diabetes in Adults. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
Authors: Richard I.G. Holt, J. Hans DeVries, Amy Hess-Fischl, Irl B. Hirsch, M. Sue Kirkman, Tomasz Klupa, Barbara Ludwig, Kirsten Nørgaard, Jeremy Pettus, Eric Renard, Jay S. Skyler, Frank J. Snoek, Ruth S. Weinstock, Anne L. Peters
Journal: Diabetes Care (2021)

The American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) convened a writing group to develop a consensus statement on the management of type 1 diabetes in adults. The writing group has considered the rapid development of new treatments and technologies and addressed the following topics: diagnosis, aims of management, schedule of care, diabetes self-management education and support, glucose monitoring, insulin therapy, hypoglycemia, behavioral considerations, psychosocial care, diabetic ketoacidosis, pancreas and islet transplantation, adjunctive therapies, special populations, inpatient management, and future perspectives. Although we discuss the schedule for follow-up examinations and testing, we have not included the evaluation and treatment of the chronic microvascular and macrovascular complications of diabetes as these are well-reviewed and discussed elsewhere. The writing group was aware of both national and international guidance on type 1 diabetes and did not seek to replicate this but rather aimed to highlight the major areas that health care professionals should consider when managing adults with type 1 diabetes. Though evidence-based where possible, the recommendations in the report represent the consensus opinion of the authors.
1055P Prognostic relevance of tumor-infiltrating lymphocytes in early-stage melanoma
Authors: E. Chatziioannou, J. Rossner, H. Niessner, S. Forchhammer, I. Bonzheim, C. Garbe, L. Flatz, T. Eigentler, T. Aung, D. Rimm, T. Sinnberg, T.M.S. Amaral
Journal: Annals of Oncology (2021)
713P Assessment of bleomycin pulmonary toxicity in men with poor-prognosis non-seminomatous germ-cell tumors treated in the GETUG 13 phase III trial
Authors: N. Naoun, G. Le Teuff, L. Pagliaro, A. Fléchon, J. Mardiak, L. Geoffrois, P. Kerbrat, C.M. Chevreau, R. Delva, F. Rolland, C. Theodore, G. Roubaud, G. Gravis, J-C. Eymard, J.P. Malhaire, C. Linassier, M. Reckova, S. Nenan, S. Culine, K. Fizazi
Journal: Annals of Oncology (2021)
6-month follow-up of VIALE-C demonstrates improved and durable efficacy in patients with untreated AML ineligible for intensive chemotherapy
Authors: Andrew H. Wei, Panayiotis Panayiotidis, Pau Montesinos, Kamel Laribi, Vladimir Ivanov, Inho Kim, Jan Novak, Don A. Stevens, Walter Fiedler, Maria Pagoni, Julie Bergeron, Stephen B. Ting, Jing-Zhou Hou, Achilles Anagnostopoulos, Andrew McDonald, Vidhya Murthy, Takahiro Yamauchi, Jianxiang Wang, Brenda Chyla, Yan Sun, Qi Jiang, Wellington Mendes, John Hayslip, Courtney D. DiNardo
Journal: Blood Cancer Journal (2021)

Abstract VIALE-C compared the safety and efficacy of venetoclax or placebo plus low-dose cytarabine (+LDAC) in patients with untreated AML ineligible for intensive chemotherapy. Overall, 211 patients were enrolled ( n = 143, venetoclax; n = 68, placebo). At the primary analysis, the study did not meet its primary endpoint of a statistically significant improvement in overall survival (OS), however, ~60% of patients had been on study for ≤6-months. Here, we present an additional 6-months of follow-up of VIALE-C (median follow-up 17.5 months; range 0.1–23.5). Median OS was (venetoclax +LDAC vs. placebo +LDAC) 8.4 vs. 4.1 months (HR = 0.70, 95% CI 0.50,0.99; P = 0.040); a 30% reduction in the risk of death with venetoclax. Complete response (CR)/CR with incomplete hematologic recovery (CRi) rates were 48.3% vs. 13.2%. Transfusion independence rates (RBC) were 43% vs.19% and median event-free survival was 4.9 vs. 2.1 months (HR = 0.61; 95% CI 0.44,0.84; P = 0.002). These results represent improved efficacy over the primary analysis. Incidence of grade ≥3 adverse events were similar between study arms and overall safety profiles were comparable to the primary analysis. These data support venetoclax +LDAC as a frontline treatment option for patients with AML ineligible for intensive chemotherapy. This trial was registered at www.clinicaltrials.gov as #NCT03069352.
Utility of Dynamic Hepatobiliary Scintigraphy in Identifying a Duct of Luschka Bile Leak
Authors: Connor Crowley, Saeed Elojeimy, William J. Rieter
Journal: Clinical Nuclear Medicine (2021)

Hepatobiliary scintigraphy is a sensitive tool for the detection of a suspected bile leak following cholecystectomy. Traditionally, it has been used to identify, but not localize the source of the leak. Herein we present a case of a bile leak related to a duct of Luschka injury that was identified on dynamic hepatobiliary scintigraphy, but was less evident on a concurrently acquired MRI. This case highlights the scintigraphic features of a bile leak from an accessory duct and underscores the importance of reviewing early dynamic images to potentially identify the source of a leak.
625P TMPRSS2-ERG expression and clinical evolution of metastatic hormone sensitive prostate cancer
Authors: C. Aversa, N. Jimenez, M. Marín-Aguilera, L. Ferrer, L. Rodríguez-Carunchio, S. Diaz-Mercedes, A. Font Pous, A. Rodriguez-Vida, M. Domenech Santasusana, M. Figols Gorina, M.A. Climent Duran, S. Cros Costa, I. Chirivella, D. Herrero Rivera, E. Gonzalez-Billalabeitia, D. Jiménez-Peralta, J. Carles Galceran, C. Suarez Rodriguez, O. Reig Torras, B. Mellado
Journal: Annals of Oncology (2021)
1073P Quality of life (QOL) endpoints from the phase III intergroup S1404 adjuvant melanoma trial
Authors: S. Patel, J.M. Unger, M. Othus, A. Darke, A.A. Tarhini, J.M. Kirkwood, E. Sharon, V. Sondak, A. Ribas, K.F. Grossmann
Journal: Annals of Oncology (2021)
Spotlight influenza: The 2019/20 influenza season and the impact of COVID-19 on influenza surveillance in the WHO European Region
Authors: Cornelia Adlhoch, Miriam Sneiderman, Oksana Martinuka, Angeliki Melidou, Nick Bundle, James Fielding, Sonja J Olsen, Pasi Penttinen, Lucia Pastore, Richard Pebody
Journal: Eurosurveillance (2021)

BackgroundAnnual seasonal influenza activity in the northern hemisphere causes a high burden of disease during the winter months, peaking in the first weeks of the year.AimWe describe the 2019/20 influenza season and the impact of the COVID-19 pandemic on sentinel surveillance in the World Health Organization (WHO) European Region.MethodsWe analysed weekly epidemiological and virological influenza data from sentinel primary care and hospital sources reported by countries, territories and areas (hereafter countries) in the European Region.ResultsWe observed co-circulation of influenza B/Victoria-lineage, A(H1)pdm09 and A(H3) viruses during the 2019/20 season, with different dominance patterns observed across the Region. A higher proportion of patients with influenza A virus infection than type B were observed. The influenza activity started in week 47/2019, and influenza positivity rate was ≥ 50% for 2 weeks (05-06/2020) rather than 5-8 weeks in the previous five seasons. In many countries a rapid reduction in sentinel reports and the highest influenza activity was observed in weeks 09-13/2020. Reporting was reduced from week 14/2020 across the Region coincident with the onset of widespread circulation of SARS-CoV-2.ConclusionsOverall, influenza type A viruses dominated; however, there were varying patterns across the Region, with dominance of B/Victoria-lineage viruses in a few countries. The COVID-19 pandemic contributed to an earlier end of the influenza season and reduced influenza virus circulation probably owing to restricted healthcare access and public health measures.
346MO Safety of idroxioleic acid in combination with standard of care (temozolomide and/or radiation therapy) in newly diagnosed glioblastoma patients: A phase Ib trial
Authors: C. Balaña, S. del Barco Berrón, A. Stradella, R. Villanueva Vazquez, A. Cuesta, J.V. Torres, J. Roma, R. Taylor, P.V. Escriba, E. Llobet, A.G. McNicholl
Journal: Annals of Oncology (2021)
247P Efficacy and safety of ribociclib (RIB) in combination with letrozole (LET) in patients with estrogen receptor–positive advanced breast cancer (ABC): Secondary and exploratory results of phase 3b RIBECCA study
Authors: T. Decker, P.A. Fasching, A. Nusch, A. Hartkopf, B.J. Heinrich, C.M. Kurbacher, R. Fuchs, H. Tesch, P. Krabisch, J. Huober, S. Kümmel, S.Y. Brucker, W. Janni, A. Schneeweiss, M. Schuler, T.N. Fehm, D. Lüftner, None C. Quiering, J. Kreuzeder, M. Reinisch
Journal: Annals of Oncology (2021)
474P Genomic characterization and clinical outcomes of patients (pts) with metastatic colorectal cancer (mCRC) with peritoneal metastases (PM) in AACR project GENIE
Authors: E. Sanz Garcia, G.J. Riely, E.M. Lepisto, M.L. LeNoue-Newton, J.L. Warner, S.M. Sweeney, C.G. McCarthy, J. Weiss, C. Yu, P.J. Voon, D. Schrag, A. Govindarajan, P. Bedard
Journal: Annals of Oncology (2021)
COVID-19 Vaccine Decision-making Factors in Racial and Ethnic Minority Communities in Los Angeles, California
Authors: Savanna L. Carson, Alejandra Casillas, Yelba Castellon-Lopez, Lisa N. Mansfield, D’Ann Morris, Juan Barron, Ejiro Ntekume, Raphael Landovitz, Stefanie D. Vassar, Keith C. Norris, Steven M. Dubinett, Nanibaa’ A. Garrison, Arleen F. Brown
Journal: JAMA Network Open (2021)

The COVID-19 pandemic has had disproportionate effects on racial and ethnic minority communities, where preexisting clinical and social conditions amplify health and social disparities. Many of these communities report lower vaccine confidence and lower receipt of the COVID-19 vaccine. Understanding factors that influence the multifaceted decision-making process for vaccine uptake is critical for narrowing COVID-19-related disparities.
Immediate versus Postponed Intervention for Infected Necrotizing Pancreatitis
Authors: Lotte Boxhoorn, Sven M. van Dijk, Janneke van Grinsven, Robert C. Verdonk, Marja A. Boermeester, Thomas L. Bollen, Stefan A.W. Bouwense, Marco J. Bruno, Vincent C. Cappendijk, Cornelis H.C. Dejong, Peter van Duijvendijk, Casper H.J. van Eijck, Paul Fockens, Michiel F.G. Francken, Harry van Goor, Muhammed Hadithi, Nora D.L. Hallensleben, Jan Willem Haveman, Maarten A.J.M. Jacobs, Jeroen M. Jansen, Marnix P.M. Kop, Krijn P. van Lienden, Eric R. Manusama, J. Sven D. Mieog, I. Quintus Molenaar, Vincent B. Nieuwenhuijs, Alexander C. Poen, Jan-Werner Poley, Marcel van de Poll, Rutger Quispel, Tessa E.H. Römkens, Matthijs P. Schwartz, Tom C. Seerden, Martijn W.J. Stommel, Jan Willem A. Straathof, Hester C. Timmerhuis, Niels G. Venneman, Rogier P. Voermans, Wim van de Vrie, Ben J. Witteman, Marcel G.W. Dijkgraaf, Hjalmar C. van Santvoort, Marc G. Besselink
Journal: New England Journal of Medicine (2021)

Infected necrotizing pancreatitis is a potentially lethal disease that is treated with the use of a step-up approach, with catheter drainage often delayed until the infected necrosis is encapsulated. Whether outcomes could be improved by earlier catheter drainage is unknown.
DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing
Authors: Yufeng Li, Junyu Xu, Yuting Lu, Hua Bian, Lin Yang, Honghong Wu, Xinwen Zhang, Beilei Zhang, Maoqian Xiong, Yafei Chang, Jie Tang, Fan Yang, Lei Zhao, Jing Li, Xin Gao, Mingfeng Xia, Minjia Tan, Jingya Li
Journal: Cell Metabolism (2021)

Nonalcoholic steatohepatitis (NASH) is an advanced stage of nonalcoholic fatty liver disease (NAFLD) with serious consequences that currently lacks approved pharmacological therapies. Recent studies suggest the close relationship between the pathogenesis of NAFLD and the dysregulation of RNA splicing machinery. Here, we reveal death-associated protein kinase-related apoptosis-inducing kinase-2 (DRAK2) is markedly upregulated in the livers of both NAFLD/NASH patients and NAFLD/NASH diet-fed mice. Hepatic deletion of DRAK2 suppresses the progression of hepatic steatosis to NASH. Comprehensive analyses of the phosphoproteome and transcriptome indicated a crucial role of DRAK2 in RNA splicing and identified the splicing factor SRSF6 as a direct binding protein of DRAK2. Further studies demonstrated that binding to DRAK2 inhibits SRSF6 phosphorylation by the SRSF kinase SRPK1 and regulates alternative splicing of mitochondrial function-related genes. In conclusion, our findings reveal an indispensable role of DRAK2 in NAFLD/NASH and offer a potential therapeutic target for this disease.
6-wk vs. 12-wk antibiotic therapy increased persistent infection in prosthetic joint infections managed surgically
Authors: Vincent J. Mariano, Eleftherios Mylonakis
Journal: Annals of Internal Medicine (2021)

ACP Journal ClubOctober 20216-wk vs. 12-wk antibiotic therapy increased persistent infection in prosthetic joint infections managed surgicallyVincent J. Mariano, MD, Eleftherios Mylonakis, MD, PhDVincent J. Mariano, MDRhode Island Hospital/ Brown University, Providence, Rhode Island, USA (V.J.M., E.M.)Search for more papers by this author, Eleftherios Mylonakis, MD, PhDRhode Island Hospital/ Brown University, Providence, Rhode Island, USA (V.J.M., E.M.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJ202110190-116 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationBernard L, Arvieux C, Brunschweiler B, et al. Antibiotic therapy for 6 or 12 weeks for prosthetic joint infection. N Engl J Med. 2021;384:1991-2001. https://pubmed.ncbi.nlm.nih.gov/34042388Clinical Impact RatingsInfectious Disease: References1. Osmon DR, Berbari EF, Berendt AR, et al. Diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis. 2013;56:e1-25. [PMID: 23223583] Google Scholar2. Lee RA, Centor RM, Humphrey LL, et al. Appropriate use of short-course antibiotics in common infections: best practice advice from the American College of Physicians. Ann Intern Med. 2021;174:822-7. [PMID: 33819054] Google Scholar3. Li HK, Rombach I, Zambellas R, et al. Oral versus intravenous antibiotics for bone and joint infection. N Engl J Med. 2019;380:425-36. [PMID: 30699315] Google Scholar Author, Article, and Disclosure InformationAffiliations: Rhode Island Hospital/ Brown University, Providence, Rhode Island, USA (V.J.M., E.M.)Disclosures: The commentators have reported no disclosures of interest. The forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M20-7321.This article was published at Annals.org on 5 October 2021. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics October 2021Volume 174, Issue 10Page: JC116 ePublished: 5 October 2021 Issue Published: October 2021 Copyright & PermissionsCopyright © 2021 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
1192MO Amivantamab monotherapy and in combination with lazertinib in post-osimertinib EGFR-mutant NSCLC: Analysis from the CHRYSALIS study
Authors: N.B. Leighl, C.A. Shu, A. Minchom, E. Felip, S. Cousin, B.C. Cho, K. Park, J-Y. Han, M. Boyer, C.K. Lee, V. Moreno Garcia, P. Tomasini, S. Viteri, J. Xie, J. Mertz, E. Artis, R.W. Schnepp, R.E. Knoblauch, M. Thayu, J.M. Trigo Perez
Journal: Annals of Oncology (2021)
1122TiP A phase II trial to evaluate the safety and dosimetry of [177Lu]Lu-DOTA-TATE in adolescent patients with somatostatin receptor (SSTR)-positive gastroenteropancreatic neuroendocrine tumours (GEP-NETs), pheochromocytomas and paragangliomas (PPGLs)
Authors: M.N. Gaze, M.S. O'Dorisio, C. Sábado, F. Brouri, I. Folitar
Journal: Annals of Oncology (2021)
If music be the food of love, play on: Four ways that music may lead to social connection
Authors: Shira Gabriel, Elaine Paravati
Journal: Behavioral and Brain Sciences (2021)

Abstract The hypothesis that music is well suited to facilitate social bonding (Savage et al., target article) is highly consistent with social psychological research on the need to belong. We explore how music is uniquely placed to increase feelings of connections to large collectives by increasing collective effervescence, providing narratives, reminding one of others, and providing social surrogates.
Whole-body and muscle responses to aerobic exercise training and withdrawal in ageing and COPD
Authors: Lorna E. Latimer, Dumitru Constantin-Teodosiu, Bhavesh Popat, Despina Constantin, Linzy Houchen-Wolloff, Charlotte E. Bolton, Michael C. Steiner, Paul L. Greenhaff
Journal: European Respiratory Journal (2021)

Background Chronic obstructive pulmonary disease (COPD) patients exhibit lower peak oxygen uptake ( V ′ O 2 peak ), altered muscle metabolism and impaired exercise tolerance compared with age-matched controls. Whether these traits reflect muscle-level deconditioning (impacted by ventilatory constraints) and/or dysfunction in mitochondrial ATP production capacity is debated. By studying aerobic exercise training (AET) at a matched relative intensity and subsequent exercise withdrawal period we aimed to elucidate the whole-body and muscle mitochondrial responsiveness of healthy young (HY), healthy older (HO) and COPD volunteers to whole-body exercise. Methods HY (n=10), HO (n=10) and COPD (n=20) volunteers were studied before and after 8 weeks of AET (65% V ′ O 2 peak ) and after 4 weeks of exercise withdrawal. V ′ O 2 peak , muscle maximal mitochondrial ATP production rate (MAPR), mitochondrial content, mitochondrial DNA (mtDNA) copy number and abundance of 59 targeted fuel metabolism mRNAs were determined at all time-points. Results Muscle MAPR (normalised for mitochondrial content) was not different for any substrate combination in HO, HY and COPD at baseline, but mtDNA copy number relative to a nuclear-encoded housekeeping gene (mean± sd ) was greater in HY (804±67) than in HO (631±69; p=0.041). AET increased V ′ O 2 peak in HO (17%; p=0.002) and HY (21%; p&lt;0.001), but not COPD (p=0.603). Muscle MAPR for palmitate increased with training in HO (57%; p=0.041) and HY (56%; p=0.003), and decreased with exercise withdrawal in HO (−45%; p=0.036) and HY (−30%; p=0.016), but was unchanged in COPD (p=0.594). mtDNA copy number increased with AET in HY (66%; p=0.001), but not HO (p=0.081) or COPD (p=0.132). The observed changes in muscle mRNA abundance were similar in all groups after AET and exercise withdrawal. Conclusions Intrinsic mitochondrial function was not impaired by ageing or COPD in the untrained state. Whole-body and muscle mitochondrial responses to AET were robust in HY, evident in HO, but deficient in COPD. All groups showed robust muscle mRNA responses. Higher relative exercise intensities during whole-body training may be needed to maximise whole-body and muscle mitochondrial adaptation in COPD.
Abstract 13207: Re-Imagining the Engaged Visit With Emergent Technology
Authors: Jake Delatorre-Reimer, Cory Mosser, Hannah Husby, Xiaowei (Sherry) Yan, Shuting (Lily) Liang, JB Jones, Karen MacDonald
Journal: Circulation (2018)

Introduction: Burdensome administrative tasks and ballooning panel sizes have made managing the increasing prevalence of cardiometabolic (CM) conditions such as diabetes, hypertension, and dyslipid...
112P Prognostic impact of five serum biomarkers in patients with advanced non-small cell lung cancer (NSCLC): An exploratory analysis
Authors: Y.M. Nassar, F.W. Ojara, S. Holdenrieder, K. Krueger, M. Joerger, R. Michelet, W. Huisinga, C. Kloft
Journal: Annals of Oncology (2021)
763P Treatment response to non-platinum therapies in ovarian cancer patients according to BRCA status: A retrospective analysis of a large multicentric cohort
Authors: G. Giannone, E. Ghisoni, D. Katsaros, G. Scotto, U. De Giorgi, A. Farolfi, F. Borella, A. Ferrero, S. Gemmiti, S. Cosma, M. Villa, V. Tuninetti, M. Turinetto, G. Mittica, L. Zavallone, M. Aglietta, B. Pasini, M. Di Maio, G. Valabrega
Journal: Annals of Oncology (2021)
Annals Graphic Medicine - Dr. Mom: T-Shirts I Would Like
Authors: Grace E. Farris
Journal: Annals of Internal Medicine (2021)

Web ExclusivesOctober 2021Annals Graphic Medicine - Dr. Mom: T-Shirts I Would LikeFREEGrace E. Farris, MDGrace E. Farris, MDUniversity of Texas, Austin, Texas (G.E.F.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/G21-0058 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Download figure Download PowerPoint Comments0 CommentsSign In to Submit A Comment Cornelia Taylorassistant professor of medicine at Dell Medical School at the University of Texas in Austin, Texas27 September 2021 T shirts I'd like to have I love, love, love Dr. Farris' creativity and sense of humor. It brings a big smile to my face when I see her work. Please keep up the good work! Author, Article, and Disclosure InformationAffiliations: University of Texas, Austin, Texas (G.E.F.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=G21-0024.Author/Illustrator Information: Grace E. Farris, MD, is an assistant professor of medicine at Dell Medical School at the University of Texas in Austin, Texas. You can view her work at her website: www.farrisgrace.com.About Dr. Mom: In Dr. Mom, physician and cartoonist Grace Farris examines work–life balance while mothering and doctoring. Dr. Mom appears monthly in Annals Graphic Medicine at Annals.org.This article was published at Annals.org on 28 September 2021. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics October 2021Volume 174, Issue 10Page: W92-W93 ePublished: 28 September 2021 Issue Published: October 2021 Copyright & PermissionsCopyright © 2021 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Musical bonds are orthogonal to symbolic language and norms
Authors: Connor Wood
Journal: Behavioral and Brain Sciences (2021)

Abstract Both Mehr et al.'s credible signaling hypothesis and Savage et al.'s music and social bonding hypothesis emphasize the role of multilevel social structures in the evolution of music. Although empirical evidence preferentially supports the social bonding hypothesis, rhythmic music may enable bonding in a way uniquely fitted to the normative and language-based character of multilevel human societies.
40P Evolutionary trajectories and clonal migration underlying tumor progression and lymph node metastasis in resectable lung cancer
Authors: S. Wang, C. Wang, J. Zhang, M. Li, F. Jiang, X. Fan, M. Wu, H. Bao, R. Yu, X. Wu, Y. Shao, L. Xu, R. Yin
Journal: Annals of Oncology (2021)