tbuckley/cabot-search huggingface dataset:
Failure of antiarrhythmic drugs to prevent experimental reperfusion ventricular fibrillation.
Authors: MNaito, E LMichelson, J JKmetzo, EKaplinsky, L SDreifus
Journal: Circulation (1981)

Ninety-nine adult mongrel dogs underwent acute ligation of the proximal left anterior descending coronary artery. Thirty minutes later, the occlusion was released to evaluate the effectiveness of five antiarrhythmic protocols in eliminating reperfusion ventricular fibrillation. The five protocols included: protocol 1 --i.v. lidocaine, preligation and prerelease (n = 19); protocol 2 -- i.v. lidocaine, prereperfusion only (n = 22); protocol 3 -- chronic, oral, daily amiodarone for 2 weeks preligation (n = 19); protocol 4 -- i.v. procainamide, preligation and prereperfusion (n = 21); and protocol 5 -- i.v. verapamil, prereperfusion (n = 18). Each regimen was evaluated with respect to the incidence of reperfusion ventricular fibrillation in dogs that survived to reperfusion, and the results were compared to 77 control dogs that underwent identical coronary artery occlusion and release procedures without drug therapy. The incidence of reperfusion ventricular fibrillation was as follows: protocol 1 -- seven of ...
Modification of human atrioventricular nodal function by selective atrioventricular nodal artery catheterization.
Authors: P JWang, GSosa-Suarez, P LFriedman
Journal: Circulation (1990)

The hypothesis that human atrioventricular (AV) nodal function can be modulated selectively with a new technique of AV nodal artery catheterization was tested in eight subjects referred for diagnostic cardiac catheterization or electrophysiological studies. Three patients had no history of arrhythmias. Three patients had supraventricular tachycardia (SVT) due to reentry confined to the AV node (AVNRT). One patient had SVT due to reentry over a concealed AV bypass tract (AVRT-CBT), and one patient had nonsustained ventricular tachycardia. In each subject, sinus cycle length, AH interval, HV interval, AV nodal effective refractory period (AVN-ERP), and Wenckebach paced cycle length were measured in a control state. A flexible infusion catheter was then positioned selectively in the AV nodal artery of each subject. Through this catheter, a constant infusion of 0.1 mg/min procainamide at a flow rate of 0.125 ml/min (n = 1) or 50 micrograms/min acetylcholine at a flow rate of 0.25 ml/min (n = 4) was administer...
Literacy and Misunderstanding Prescription Drug Labels
Authors: Christopher T. Parker
Journal: Annals of Internal Medicine (2007)

Letters21 August 2007Literacy and Misunderstanding Prescription Drug LabelsChristopher T. Parker, DOChristopher T. Parker, DOFrom Austin Diagnostic Clinic, Austin, TX 78758.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-147-4-200708210-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:After reading with interest the article (1) and accompanying editorial (2) about literacy and patient understanding of prescription labels, I would like to offer an additional suggestion. As a clinical rheumatologist who prescribes medications at many different intervals (daily, weekly, twice monthly, every other month, etc.), I find that prescribing medication is only getting more complex as new drugs are released for the diseases I encounter (systemic autoimmunity and bone and joint disorders). In my experience, patients adhere to the regimen better if they know why they are taking the medication. It is surprising how many patients ...References1. Davis TC, Wolf MS, Bass PF, Thompson JA, Tilson HH, Neuberger M, et al. Literacy and misunderstanding prescription drug labels. Ann Intern Med. 2006;145:887-94. [PMID: 17135578] LinkGoogle Scholar2. Schillinger D. Misunderstanding prescription labels: the genie is out of the bottle [Editorial]. Ann Intern Med. 2006;145:926-8. [PMID: 17135577] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Christopher T. Parker, DOAffiliations: From Austin Diagnostic Clinic, Austin, TX 78758.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoLiteracy and Misunderstanding Prescription Drug Labels Terry C. Davis , Michael S. Wolf , Pat F. Bass III , Jason A. Thompson , Hugh H. Tilson , Marolee Neuberger , and Ruth M. Parker Misunderstanding Prescription Labels: The Genie Is Out of the Bottle Dean Schillinger Literacy and Misunderstanding Prescription Drug Labels David Katz Literacy and Misunderstanding Prescription Drug Labels Ali Jawaid Literacy and Misunderstanding Prescription Drug Labels Munsey S. Wheby Metrics Cited byHealth Literacy, Primary Care Health Care Providers, and CommunicationHealth literacy among patients with poor understanding of prescription drug label instructions in Saudi ArabiaRethinking the Patient Education Council Format to Increase Efficiency 21 August 2007Volume 147, Issue 4Page: 280-281KeywordsAutoimmunityBoneConflicts of interestDrugsGoutLiteracySystemic diseases ePublished: 21 August 2007 Issue Published: 21 August 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Restenosis after successful coronary angioplasty in patients with single-vessel disease.
Authors: P PLeimgruber, G SRoubin, JHollman, G ACotsonis, BMeier, J SDouglas, S BKing, A RGruentzig
Journal: Circulation (1986)

To determine risk factors for restenosis, we studied 998 patients who underwent elective coronary angioplasty (PTCA) to native coronary arteries between July 1980 and July 1984. Restenosis, defined as a luminal narrowing of greater than 50% at follow-up, was present in 302 patients (30.2%). Univariate analysis of 29 factors revealed seven factors related to restenosis: vessel dilated (circumflex coronary artery 18%, right coronary artery 27%, left anterior descending artery 34%; p less than .01), final gradient of 15 mm Hg or less compared with greater than 15 mm Hg (27% vs 38%, p less than .01), duration of angina greater than 2 months compared with angina of shorter duration (27% vs 35%, p = .01), post-PTCA stenosis of 30% or less compared with 31% to 50% (28% vs 36%, p less than .025), stable vs unstable angina (26% vs 34%, p less than .05), presence vs absence of intimal dissection (26% vs 32%, p = .07), and female gender vs male gender (25% vs 32%, p = .08). Multivariate analysis revealed five factor...
Effects of infarcted myocardium on regional blood flow measurements to ischemic regions in canine heart.
Authors: R HMurdock, F RCobb
Journal: Circulation Research (1980)

The present study assesses effects of acutely infarcted myocardium on apparent microsphere loss as a function of time, determines effects of apparent microsphere loss on blood flow measurements to ischemic regions, and determines to what extent apparent microsphere loss alters interpretation of serial measurements of collateral blood flow. Studies were performed in 35 awake mongrel dogs chronically instrumented with catheters in the aorta and left atrium and an occluder on the proximal circumflex coronary artery. Myocardial blood flow was measured before and 15 minutes after complete occlusion. Dogs were randomly divided into four groups to be killed at 6 and 24 hours, and 3 and 6 days. In the 3-day group, an additional blood flow measurement was made 24 hours postocclusion. The entire left ventricle was sectioned into 1- to 2-g samples and myocardial blood flow determined. The ratio of preocclusion blood flow in each ischemic sample to mean nonischemic flow was used to calculate apparent microsphere loss...
Jaundice as a presentation of heart failure
Authors: O M P Jolobe
Journal: Journal of the Royal Society of Medicine (2005)

Jaundice as a presentation of heart failureAs many as 55% of 42 patients with severe congestive cardiac failure (CCF) (characterized by a cardiac index of 1.5 L/ min/m 2 or less) may have raised serum alkaline phosphatase, 1 yielding a prevalence of this liver enzyme derangement twice that documented by van Lingen et al. (September 2005 JRSM 2 ).Accordingly, jaundice and/or serum alkaline phosphatase hotline would be more informative than an exclusively jaundice hotline service for elucidating the distinguishing features (if any) of those patients in whom CCF co-exists with potentially treatable choledocholithiasis.This scenario is especially likely in the elderly, in whom the age-related nature of the two disorders 3,4 makes it increasingly likely that they will co-exist by pure chance; the confusion between the two disorders is compounded when co-prescription of warfarin is complicated either by idiosyncratic warfarin-related cholestasis 5 or by anticoagulant-related haemobilia. 6 I agree that correct evaluation of jugular venous pressure (JVP) is crucial to the differential diagnosis between CCFrelated jaundice and other causes of jaundice.[I would add that the time is long overdue for non-cardiology internists to abandon the so-called 'JVP raised to 2 cm' calibration so widely prevalent in the clerking of CCF patients].However, this is not the whole story.The biochemical stigmata of CCF-related jaundice can be indistinguishable from those of choledocholithiasis, 1 justifying a vigilant awareness of the possibility of the co-existence of the two disorders in every CCF patient in whom serum alkaline phosphatase of hepatic origin is elevated to twice or more of the upper limit of normal, irrespective of the severity of jaundice, and, possibly, even regardless of whether or not the patient is jaundiced. 7
Commentary: Managing clinicians' assessment
Authors: R. Reuss, M. Bolz, U. K Zettl
Journal: BMJ (2009)

When Mrs G presented to the emergency room, clinical examination with transverse spinal cord syndrome, magnetic resonance imaging, and her complete clinical remission after plasmapheresis as well as lack of response to treatment pointed to longitudinally extensive transverse myelitis, representing an inaugural or limited form of neuromyelitis optica. The diagnosis was confirmed by detection of anti-aquaporin 4 (AQP4) antibodies.

In the rapid responses Mike Boggild states that a variety of other autoantibodies are often seen within the spectrum of neuromyelitis optica disorders.1 Conversely, several cases of pregnancy related …
Role of sodium in hypertensive cardiac hypertrophy.
Authors: KLindpaintner, SSen
Journal: Circulation Research (1985)

Cardiac hypertrophy in systemic hypertension may not result simply from increased afterload. Previous studies indicate that factors other than blood pressure may influence cardiac hypertrophy. We evaluated the effects of dietary sodium restriction in two-kidney one-clip renal hypertensive rats. After the renal artery had been clipped, the rats received a normal diet until hypertension was established; thereafter, a sodium-deficient diet was instituted in one group. Clipped rats on a regular diet had significantly higher systolic blood pressures than sham-operated controls (205 +/- 9 vs. 129 +/- 1 mm Hg, respectively). Sodium restriction did not reverse hypertension (190 +/- 8 mm Hg), but led to a significant reduction of relative heart weight compared to rats on the normal diet (2.94 +/- 0.24 vs. 3.86 +/- 0.23 mg/g, respectively; P less than 0.01). The hypertrophied hearts of animals on the regular diet showed depressed tissue catecholamines (significant only for norepinephrine); sodium restriction result...
Acetyl glyceryl ether phosphorylcholine (AGEPC). A putative mediator of cardiac anaphylaxis in the guinea pig.
Authors: RLevi, J ABurke, Z GGuo, YHattori, C MHoppens, L MMcManus, D JHanahan, R NPinckard
Journal: Circulation Research (1984)

Platelet-activating factor is a novel phospholipid that has been implicated as an important mediator of acute allergic reactions. The intravenous administration of acetyl glyceryl ether phosphorylcholine, a pure, synthetic platelet-activating factor, causes electrocardiographic changes in the rabbit similar to those which are characteristic manifestations of systemic anaphylaxis. To determine whether platelet-activating factor contributes to anaphylactic cardiac dysfunction, we measured platelet-activating factor release from the sensitized guinea pig heart challenged in vitro with specific antigen and compared the resulting cardiac dysfunction with that induced by the injection of acetyl glyceryl ether phosphorylcholine into nonsensitized hearts. The results of these studies document that, during anaphylaxis in the isolated guinea pig heart, a platelet-activating factor is released into the coronary effluent that has physicochemical and functional properties similar to those of acetyl glyceryl ether phos...
Effectiveness of right heart catheterization: time for a randomized trial
Authors: R. J. Beale
Journal: JAMA (1997)

To the Editor.  —The analysis of the effectiveness of the RHC by Dr Connors and colleagues 1 raises important questions. The crux of the problem is that RHC is a monitoring device, not a treatment, and the increased risk of death in the RHC group was associated with an increase in intervention. The information the authors provide does not allow RHC effects and treatment effects to be separated. It is possible that the presence of an RHC is harmful and results in a worse outcome, but it is generally accepted that insertion is safe when performed by an experienced physician and that the complication rate is low. 2 Moreover, the relative hazard of death was only 1.02 (95% confidence interval, 0.55-1.89; P =.94) in the patients with congestive cardiac failure, who might be considered most at risk from a direct complication of the RHC. Another possibility, referred to by the authors, is
Surveillance and Endoscopic Recognition of Gastric Intestinal Metaplasia and Atrophic Gastritis: A Retrospective Cohort Study in Two Academic Centers
Authors: J Honing, E Dieninyte, M O’Donovan, LA Brosens, RC Fitzgerald, BL Weusten, M di Pietro
Journal: Endoscopy (2021)

Aims Endoscopic recognition of GIM and GA is challenging and little is known regarding adherence to surveillance guidelines in Western centers, particularly those with low incidence of gastric adenocarcinoma. The aim of this study was to evaluate endoscopic recognition and adequacy of surveillance for GIM and GA.
A new ECG classification system for myocardial infarction based on receiver operating characteristic curve analysis and information theory.
Authors: CAbreu-Lima, D MCorreia, JAlmeida, MAntunes-Lopes, MCerqueira-Gomes
Journal: Circulation (1983)

An optimized three-lead ECG hierarchial decision-tree type of classification system for myocardial infarction is presented. For selection of the best threshold values for each criterion and the best association of features, we developed a procedure based on receiver operating characteristic (ROC) curve data analysis and information theory. Optimization was obtained through maximization of information content of the criteria. The classifier is based on nine measurements that can be easily obtained by hand (QX duration, Q/R Y amplitude, R Y amplitude, Q/R Y duration, Q Z amplitude, QRS and T axes in the horizontal plane, Q Z duration and R Z amplitude) and achieved a satisfactory performance in an independent group of patients (true-positive ratio 0.853, false-positive ratio 0.105, average information content 0.308 bits).
Response of the cerebral circulation in baboons to changing perfusion pressure after indomethacin.
Authors: J DPickard, L AMacDonell, E TMacKenzie, A MHarper
Journal: Circulation Research (1977)

An earlier study has demonstrated that indomethacin, a prostaglandin synthesis inhibitor, blocks the cerebrovascular response to hypercapnia. This response is believed to be mediated by a lowering of pH in the cerebral interstitial fluid. Should autoregulation of cerebral blood flow (CBF) to changing perfusion pressure also be mediated by a changing interstitial pH (the metabolic theory), then indomethacin should impair autoregulation. This hypothesis was tested in anesthetized baboons. CBF was measured by the intracarotid 133Xe clearance technique; the preparation and the indomethacin protocol were identical to those of our previous investigation. Arterial pressure was increased by the intravenous infusion of angiotensin and decreased by controlled hemorrhage. Indomethacin was given by continuous infusion into the internal carotid artery. Although it reduced resting CBF, the cerebrovascular response to changing perfusion pressure was unchanged. Because indomethacin affects the response to changing CO2 ...
Radiofrequency catheter ablation for the treatment of human type 1 atrial flutter. Identification of a critical zone in the reentrant circuit by endocardial mapping techniques.
Authors: G KFeld, R PFleck, P SChen, KBoyce, T DBahnson, J BStein, C MCalisi, MIbarra
Journal: Circulation (1992)

BACKGROUNDRecent studies of human type 1 atrial flutter demonstrated reentry in the right atrium and an area of slow conduction in the low posteroseptal right atrium. Direct-current catheter ablation of this area has been only moderately successful in preventing recurrence. Therefore, we performed endocardial activation mapping and entrainment pace mapping during atrial flutter to determine the critical site for radiofrequency ablation of this arrhythmia.METHODS AND RESULTSTwelve consecutive patients (seven men and five women; age, 21-73 years) with type 1 atrial flutter (mean cycle length, 253 +/- 39 msec) underwent right atrial endocardial activation and entrainment pace mapping using standard transvenous catheter techniques to localize the atrial flutter reentrant circuit, the area of slow conduction, and the exit site from the area of slow conduction. Upon identifying appropriate sites, radiofrequency energy (16-29 W) was applied via a 4-mm tipped catheter. Activation mapping of atrial flutter reveale...
Pityriasis rubra pilaris in Indians
Authors: A.J. Kanwar, Surrinder Kaur
Journal: British Journal of Dermatology (1990)

Journal Article Pityriasis rubra pilaris in Indians Get access A.J. Kanwar, A.J. Kanwar Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India Search for other works by this author on: Oxford Academic Google Scholar Surrinder Kaur Surrinder Kaur Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 123, Issue 5, 1 November 1990, Page 692, https://doi.org/10.1111/j.1365-2133.1990.tb01489.x Published: 01 November 1990
Aortocoronary bypass grafting: an internist's perspective.
Authors: H DMcIntosh
Journal: Circulation (1982)

Seven hundred fifty thousand to 1 million persons in this country have undergone aortocoronary bypass grafting since 1968, but many questions regarding the indications for the procedure and its advantages and disadvantages persist. Based on this surgical experience and on observations made during the last decade regarding nonoperative therapy and changes in the natural history of coronary heart disease, at least eight considerations should influence attitudes regarding the role of surgery: (1) The operation is a significant addition to the management of some patients with coronary heart disease. (2) The operative mortality in many centers is gratifyingly low. (3) Mortality from coronary heart disease in this country has declined strikingly during the past decade. (4) Because of the declining mortality from coronary heart disease, the prognosis of patients with the disease seen in 1980 is uncertain. (5) Coronary heart disease is a progressive disease and surgery does not prevent the progression of the dise...
高血圧症患者の運動に対する心房性ナトリウム利尿ペプチド(ANP)、脳性ナトリウム利尿ペプチド(BNP)及びC型ナトリウム利尿ペプチド(CNP)の別個反応
Authors: Masuda I, Yoshimasa T, Hayashi T, Igaki T, Tanaka I, Itoh H, Nakao K
Journal: Circulation (1994)
Pilot Study of Non-Viral, RNA-Redirected Autologous Anti-CD19 Chimeric Antigen Receptor Modified T-Cells in Patients with Refractory/Relapsed Hodgkin Lymphoma (HL)
Authors: Jakub Svoboda, Susan R. Rheingold, Saar I Gill, Stephan A Grupp, Simon F Lacey, J. Joseph Melenhorst, Irina Kulikovskaya, Brandon Loudon, Naseem Kerr, Katherine T Marcucci, Kim-Marie Shea, Aliza Schmidt, Lester Lledo, Amy Marshall, Anthony R. Mato, Sunita Dwivedy Nasta, Daniel J. Landsburg, Matthew R. Youngman, Bruce L Levine, David L Porter, Carl H June, Stephen J. Schuster
Journal: Blood (2017)
Chemical inactivation of HIV on surfaces.
Authors: J. C. de Jong, B. van Klingeren
Journal: BMJ (1989)

even a hospital paediatric senior house officer post will not necessarily prepare trainees for work in the community.The Hall report clearly argues that such work depends on cultivating an advanced awareness of the way children grow and mature and a sensitivity to family interactions and parental concerns.2There is an urgent need to draw on the experience of doctors who have given decades of committed service to child health work.It is depressing in the extreme to know that those who will inevitably inherit this work as part of primary family health care will be given financial induce- ments to take responsibility for the work but that time and funds to support specific training are not in evidence.
Pulmonary atresia with intact ventricular septum and ventriculocoronary communications: surgical significance.
Authors: W NO'Connor, C MCottrill, G LJohnson, J ANoonan, E PTodd
Journal: Circulation (1982)

The first stage of a repair of pulmonary atresia with intact ventricular septum (type I) was attempted in a 2-day-old infant. At surgery, decompression of the hypertensive small right ventricle was followed by a sudden loss of myocardial contractility and death. Postmortem examination revealed a fistula with a large orifice in the right ventricular infundibulum that communicated directly with the left main coronary artery. Severe hypertensive changes indicative of abnormally high perfusion pressure were noted in the distal left coronary artery branches. The clinical course suggests that the effect of relieving right ventricular outflow obstruction was a reduction of left main coronary artery blood flow, resulting in fatal intraoperative myocardial ischemia. This unusual case draws attention to the anomalous ventriculocoronary communications often present in pulmonary atresia and their potential for limiting a successful surgical repair.
Left ventricular internal resistance and unloaded ejection flow assessed from pressure-flow relations: a flow-clamp study on isolated rabbit hearts.
Authors: S RVaartjes, H BBoom
Journal: Circulation Research (1987)

Left ventricular pressure-flow relations were studied, using excised working rabbit hearts and imposing constant flow ejections (flow-clamps) to separate the effects of flow on pressure from those of time, flow duration, starting volume, ejected volume, and volume at specified time. Pressure-flow data at given volume and time were independent of flow duration, starting volume, and ejected volume for flow-clamp durations exceeding 30 msec. Flow history independent of pressure-flow relations was linear for flow values larger than +/- 5 ml/sec. The time-varying elastance model, E(t), of the ventricle was extended with a resistive component. Transient effects of flow can be explained by including a second elastance. The resulting verified 3-component model is consistent with recent reported experimental findings. The properties of internal resistance correspond to a constant unloaded ejection flow Qmax, which was tested by extrapolating the linear pressure-flow relations to zero pressure. Qmax reached a plate...