tbuckley/cabot-search huggingface dataset:
Intracerebral hemorrhage, cerebral infarction, and subdural hematoma after acute myocardial infarction and thrombolytic therapy in the Thrombolysis in Myocardial Infarction Study. Thrombolysis in Myocardial Infarction, Phase II, pilot and clinical trial.
Authors: J MGore, MSloan, T RPrice, A MRandall, EBovill, DCollen, SForman, G LKnatterud, GSopko, M LTerrin
Journal: Circulation (1991)

In the Thrombolysis in Myocardial Infarction, Phase II pilot and clinical trial, 908 patients [326 (35.9%) in the pilot study and 582 (64.0%) in the randomized study] were treated with 150 mg recombinant tissue-type plasminogen (rt-PA) activator in combination with heparin and aspirin, and 3,016 patients [64 (2.1%) in the pilot study and 2,952 (97.9%) in the randomized study] were treated with 100 mg rt-PA in combination with heparin and aspirin. Adverse neurological events occurred in 23 patients treated with 150 mg rt-PA (2.5%) [nine cerebral infarctions (1.0%), 12 intracerebral hemorrhages (1.3%), and two subdural hematomas (0.2%)] and in 33 patients treated with 100 mg rt-PA (1.1%) [20 cerebral infarctions (0.7%), 11 intracerebral hemorrhages (0.4%), and two subdural hematomas (0.1%)]. The difference in adverse neurological events observed comparing the two rt-PA regimens was primarily due to a higher frequency of intracerebral bleeding among patients treated with 150 mg rt-PA (1.3% versus 0.4%, p les...
From the authors
Authors: P. N. Chhajed, M. Tamm
Journal: European Respiratory Journal (2007)

Long-term follow-up of thoracoscopic talc pleurodesis for primary spontaneous pneumothoraxTo the Editors:I read with interest the study by GYO ¨RIK et al.[1] of talc pleurodesis for primary spontaneous pneumothorax.The results were not surprising as they confirm previous studies.What was surprising, however, was the lack of a control group, the lack of an intention-to-treat analysis and the failure of the paper's discussion to mention these absences as a weakness.The authors report a 95% long-term success rate for talc pleurodesis, which represents 53 out of 56 patients initially treated successfully with the technique.There were, however, 112 patients who underwent the procedure.The authors were only able to contact 63 of them; the remaining 49 apparently were not contactable because of ''geographical movement.''I am troubled that an intention-to-treat analysis is not reported.Given the 53 long-term successes and 112 original treatments, I arrive at a success rate of 47%, which is half of what the authors report.Together with the lack of a control group of patients who suffered spontaneous pneumothoraces but did not undergo talc pleurodesis, I find it unclear as to what can be reliably concluded from this study.
Abnormal vasomotor changes early after coronary angioplasty. A quantitative arteriographic study of their time course.
Authors: Hel-Tamimi, G JDavies, DHackett, PSritara, OBertrand, FCrea, AMaseri
Journal: Circulation (1991)

BACKGROUNDTo study the impact of percutaneous transluminal coronary angioplasty (PTCA) on coronary vasomotion, we prospectively analyzed spontaneous changes in coronary diameter and the response to the cold pressor test and intracoronary nitroglycerin in 11 patients subjected to successful single-vessel PTCA.METHODS AND RESULTSAll antianginal medications were stopped 48 hours before each study. The minimum diameter of the PTCA segment and the diameter of a distal segment in the angioplastied vessel and of a segment in a control vessel not manipulated by the balloon catheter or guide wire were measured by computerized edge detection immediately before PTCA and 5 minutes after, 4 hours after, and 8 days after PTCA. At 4 hours, PTCA and distal segments were constricted by 38 +/- 9% and 16 +/- 5%, respectively, compared with the values at 5 minutes (p less than 0.01). Before angioplasty, the cold pressor test caused vasoconstriction of PTCA and distal segments by 23 +/- 6% (p less than 0.0001) and 15 +/- 4% (...
Feasibility of tomographic 99mTc-hexakis-2-methoxy-2-methylpropyl-isonitrile imaging for the assessment of myocardial area at risk and the effect of treatment in acute myocardial infarction.
Authors: R JGibbons, M SVerani, TBehrenbeck, P APellikka, M KO'Connor, J JMahmarian, J HChesebro, F JWackers
Journal: Circulation (1989)

99mTc-hexakis-2-methoxy-2-methylpropyl-isonitrile (Tc-Sestamibi), a new myocardial perfusion radiopharmaceutical, was injected intravenously in 11 patients within 4 hours of the onset of acute myocardial infarction before treatment with intravenous tissue-type plasminogen activator and 6-14 days later. Five patients with acute myocardial infarction who did not receive intravenous thrombolytic therapy underwent a similar injection of radiopharmaceutical. The absence of redistribution of Tc-Sestamibi permitted imaging with single-photon emission computed tomography up to 6 hours after intravenous injection to assess the distribution of myocardial perfusion at the time of administration. The region of hypoperfused myocardium on the initial images varied widely from 9% to 68% of the left ventricle and was significantly greater in anterior than in inferior infarcts (p less than 0.01). The region of hypoperfused myocardium on the final images varied widely from 0% to 63% of the left ventricle and was also great...
Multiple endocrine neoplasia type 2: A review
Authors: Jes Sloth Mathiesen, Grigoris Effraimidis, Maria Rossing, Åse Krogh Rasmussen, Lise Hoejberg, Lars Bastholt, Christian Godballe, Peter Oturai, Ulla Feldt-Rasmussen
Journal: Seminars in Cancer Biology (2021)
Effect of platelet-activating factor on microvascular permselectivity: dose-response relations and pathways of action in the hamster cheek pouch microcirculation.
Authors: P KDillon, W NDurán
Journal: Circulation Research (1988)

Platelet-activating factor (PAF) has recently been described as a mediator of inflammatory processes. In this study, we quantitated the dose-response effects of topically applied PAF on microvascular permselectivity and investigated the biochemical pathways of this compound. Permselectivity alterations were assessed by measuring the clearance of macromolecules with fluorescein isothiocyanate dextran 150 (FITC-dx 150) as a tracer. The microvascular bed of the hamster cheek pouch served as a model. PAF was found to induce leakage of macromolecules from postcapillary venules. Control FITC-dx 150 plasma clearance (+/- SEM) was 72 +/- 10 nl/90 min. Clearances of 61 +/- 10 474 +/- 145, 622 +/- 57, 301 +/- 86, and 142 +/- 3 nl/90 min were obtained at PAF concentrations of 10(-9), 10(-8), 10(-7), 10(-6), and 10(-5) M, respectively. A one-way analysis of variance showed that the population means were not equal. Multiple comparison by the Student-Newman-Keuls test demonstrated that the clearances obtained with 10(-...
Efficacy of antiarrhythmic drugs in patients with arrhythmogenic right ventricular disease. Results in patients with inducible and noninducible ventricular tachycardia.
Authors: TWichter, MBorggrefe, WHaverkamp, XChen, GBreithardt
Journal: Circulation (1992)

BACKGROUNDVentricular tachyarrhythmias are the major clinical manifestation of arrhythmogenic right ventricular disease. Although antiarrhythmic therapy has been widely advocated, there is only limited information available on the efficacy of antiarrhythmic drugs in these patients.METHODS AND RESULTSThe short- and long-term efficacies of various antiarrhythmic agents were retrospectively and prospectively analyzed in 81 patients (mean age, 39 +/- 14 years; range, 16-68 years; 61.7% males) with arrhythmogenic right ventricular disease. In 42 patients with inducible ventricular tachycardia during programmed ventricular stimulation, the following efficacy rates were obtained: class Ia and Ib drugs (n = 18), 5.6%; class Ic drugs (n = 25), 12%; beta-blockers (n = 8), 0%; sotalol (n = 38), 68.4%; amiodarone (n = 13), 15.4%; verapamil (n = 5), 0%; and drug combinations (n = 26), 15.4%. Only one of the 10 patients not responding to sotalol was treated effectively by amiodarone, whereas the remaining nine patients...
Effect of naloxone, a specific opioid inhibitor, on blood pressure fall during sleep.
Authors: PRubin, T FBlaschke, CGuilleminault
Journal: Circulation (1981)

The study was designed to investigate the possible role of endogenous opioids in the fall in blood pressure (BP) seen during initial sleep. Seven normal men, ages 20-30 years, were studied for three consecutive nights. Each night, electroencephalogram, chin electromyogram, electrooculogram, heart rate (all continuously), and blood pressure (every 15 minutes) were recorded. Night 1 was used for orientation. On nights 2 and 3, subjects received, in randomized order, an infusion of naloxone 0.2 mg/kg over 1 minute or volume-matched saline. Blood pressure data from the first 4 hours of non-rapid eye movement sleep were combined. On the placebo night, systolic BP fell from 114.6 +/- 6 mm Hg to 103.7 +/- 8 mm Hg (+/- SD) (p < 0.05, Wilcoxon rank-sum test). On the naloxone night, systolic BP did not change. Neither diastolic BP nor heart rate were influenced by naloxone. these data suggest that endogenous opioids could be involved in the fall in systolic BP seen during initial sleep.
Electrophysiologic substrate for ventricular tachycardia: correlation of properties in vivo and in vitro.
Authors: D ARichards, G JBlake, J FSpear, E NMoore
Journal: Circulation (1984)

Cardiac electrophysiologic studies were performed in three control dogs and in nine dogs with previous (8 to 22 days) anterior myocardial infarction. During programmed stimulation, no control dog had more inducible ventricular fibrillation (VF) or tachycardia (VT), three dogs with infarcts had inducible VF and six had inducible VT. Recordings in vivo were made via a plaque electrode containing 10 bipolar electrodes (3.0 x 1.5 cm) placed on the epicardial surface of the anteroapical left ventricle. Subsequently, epicardial strips (2 mm thick) from beneath the plaque were prepared for studies in vitro. Electrogram durations were significantly greater in dogs with infarcts than in control dogs both in vivo (p less than .05) and in vitro (p less than .001). Electrogram amplitudes were significantly lower in dogs with VT in vivo (p less than .05) and in vitro (p less than .001). In control animals activation was continuous and most rapid in the direction of fiber orientation; there were areas of slow and/or di...
Induction of myocardial hypertrophy after coronary ligation in rats decreases ventricular dilatation and improves systolic function.
Authors: S ELitwin, T ERaya, P GAnderson, C MLitwin, RBressler, SGoldman
Journal: Circulation (1991)

BACKGROUNDPrevious studies have shown that hypertrophy of surviving myocytes after myocardial infarction (MI) is limited. Progressive ventricular dilatation after MI may occur when compensatory hypertrophy cannot restore left ventricular (LV) wall stress to normal.METHODS AND RESULTSTo test whether induction of additional myocyte hypertrophy might prevent pathological LV remodeling after large MI, we administered 2-tetradecylglycidic acid (TDGA) 20 mg/kg/day to sham-operated (n = 12) and MI (n = 10) rats for 10 days, beginning the third day after infarction. We have previously shown that chronic inhibition of long-chain fatty acid oxidation with TDGA in rats results in myocardial hypertrophy without any apparent impairment of LV systolic function. When compared with untreated MI rats (n = 9), we found that TDGA-treated MI rats had increases in LV weight/body wt, myocyte cross-sectional area, and peak developed LV pressure during abrupt aortic occlusion. MI rats treated with TDGA had lower LV end-diastolic...
RNA: DNA Ratios in Human Tumors
Authors: Russell Hilf
Journal: JNCI Journal of the National Cancer Institute (1977)

Journal Article RNA: DNA Ratios in Human Tumors Get access JNCI: Journal of the National Cancer Institute, Volume 59, Issue 4, October 1977, Page 1053, https://doi.org/10.1093/jnci/59.4.1053 Published: 01 October 1977
Regional changes in hemodynamics and cardiac myocyte size in rats with aortocaval fistulas. 2. Long-term effects.
Authors: ZLiu, D RHilbelink, A MGerdes
Journal: Circulation Research (1991)

Regional changes in hemodynamics and cardiac myocyte size were examined in adult rats 5 months after creating a large aortocaval fistula. At that time, cardiac output, left and right ventricular pressures, and left and right ventricular dP/dtmax were measured. Subsequently, isolated cardiac myocytes were collected from the left ventricle, right ventricle, and septum for cell size measurements. Compared with sham-operated controls, percent dry weight was reduced in the liver and kidney but was unchanged in the lung. Heart rate, left ventricular systolic pressure, left ventricular dP/dtmax, and systolic aortic pressure were not changed in rats with fistulas. However, cardiac output, stroke volume, left ventricular end-diastolic pressure, and all measured parameters in the right ventricle were significantly increased. Mean cell volume and the ratio of heart weight to body weight were both elevated 92%. Cell volume, cell length, and cross-sectional area increased significantly in each heart region examined. H...
Effect of amiodarone on rat heart myosin isoenzymes.
Authors: NBagchi, T RBrown, D SSchneider, S KBanerjee
Journal: Circulation Research (1987)

The effects of amiodarone on heart weight, production of 14C-CO2 from labelled glucose, myosin ATPase activity, and myosin isoenzyme patterns were determined by comparing control and amiodarone-treated male Wistar rats. Since it has been suggested that amiodarone may interfere with thyroid hormone action on the heart, similar experiments were also carried out in hypothyroid and amiodarone-plus-triiodothyronine(T3)-treated rats, and the data were compared to those obtained in amiodarone-treated rats. Amiodarone treatment for 6 weeks resulted in lower heart weight, decreased atrial production of 14C-CO2 from labelled glucose, decreased myosin Ca-ATPase activity, and preferential synthesis of V3 isomyosin. These effects were similar to those observed in hypothyroid rats but were lesser in magnitude. T3 treatment of amiodarone-treated rats reversed all the changes induced by amiodarone. Serum thyroxine (T4) was higher in amiodarone-treated than in control rats, while serum T3 was similar. Serum T3 was higher ...
A monoclonal antibody against rabbit tissue factor inhibits thrombus formation in stenotic injured rabbit carotid arteries.
Authors: A BPawashe, PGolino, GAmbrosio, FMigliaccio, MRagni, IPascucci, MChiariello, RBach, AGaren, W KKonigsberg
Journal: Circulation Research (1994)

Tissue factor (TF) is a transmembrane protein that binds factor VII/VIIa, thus activating the extrinsic blood coagulation pathway. Since this pathway appears to be involved in the formation of intravascular thrombi, the anti-rabbit TF monoclonal antibody, AP-1, was produced and tested as an antithrombotic agent in a rabbit model of recurrent intravascular thrombosis. In this model, a plastic constrictor is positioned around the injured rabbit carotid arteries, and flow is monitored with a Doppler flow probe. This produces cyclic flow variation (CFV) in the carotid artery, which is caused by recurrent formation and dislodgment of thrombi at the site of the stenosis. After monitoring CFV pattern for 30 minutes, AP-1 was infused intravenously into nine rabbits at doses of 0.05 to 1.5 mg/kg body weight, and a control monoclonal antibody that does not react with rabbit TF was infused into four additional rabbits. In all rabbits receiving AP-1, CFV was abolished, and a steady normal blood flow was restored, ind...
TCTAP A-032 Proper Application Time and Effect of Extracorporeal Membrane Oxygenation in the Patients Who Underwent Percutaneous Coronary Intervention for Acute Myocardial Infarction with Cardiogenic Shock
Authors: Dae Young Hyun, Myung-Ho Jeong, Min Chul Kim, Kyung Hoon Cho, Doo Sun Sim, Young Joon Hong, Youngkeun Ahn
Journal: Journal of the American College of Cardiology (2021)
Monocarboxylate Transporter 1 Deficiency and Ketone Utilization
Authors: Amnon Schlegel
Journal: New England Journal of Medicine (2015)

To the Editor: Van Hasselt et al. (Nov.13 issue) 1 state that fasting, by increasing ketogenesis, is the usual precipitating condition for ketoacidosis in monocarboxylate transporter 1 (MCT1) deficiency through an increase in ketone-body levels when utilization is impaired.Fasting, or actually carbohydrate restriction, 2 works principally through reduced insulin levels and elevated free fatty acid levels, which foster ketogenesis. 3When insulin levels are sufficiently low to permit ketone-body production, increased glucagon levels further stimulate ketogenesis. 3However, the authors also list the catabolic stress of infection as another common precipitant, suggesting that infection increases ketogenesis.It is more likely that the accompanying anorexia and low carbohydrate intake are the primary factors with regard to infection, because insulin levels are stimulated by infection and ketogenesis is impaired. 4This is an important distinction, because ketogenesis can be easily prevented by the intake of small amounts of simple sugar during the prodrome and progression of infectious illness.Furthermore, the greater susceptibility to ketoacidosis in MCT1 deficiency with younger age may be related to the greater susceptibility to ketogenesis with fasting, which correlates inversely with age. 5
Changes in cyclic nucleotide levels and contractile force in the isolated hypoxic rat heart during perfusion with glucagon.
Authors: R WBusuttil, R JPaddock, J WFisher, W JGeorge
Journal: Circulation Research (1976)

Isolated rat hearts were perfused with hormonal concentrations of glucagon during a hypoxic perfusion to determine whether it would enhance recovery after reoxygenation. Rat hearts were divided into two groups: (1) those perfused with glucose-free Tyrode's solution and (2) those perfused with Tyrode's solution containing glucose. During 3 minutes of exposure to hypoxia both untreated hearts and hearts perfused with glucagon demonstrated a decrease in contractile force to 10-20% of control. When glucose was present in the perfusion medium, cardiac performance was better during both the periods of hypoxia and reoxygenation. During reoxygenation, recovery of contractile force was significantly better (P less than 0.05) in glucagon-perfused hearts than in untreated hearts; this improved recovery occurred regardless of whether glucose was included in the medium. The enhanced recovery of the glucagon-perfused hearts was associated with decreases in myocardial levels of guanosine, 3',5'-monophosphate (cyclic GMP...
Harmful Effects of Proton Pump Inhibitors
Authors: Arief Lalmohamed, Niels Vermeer, Frank de Vries
Journal: JAMA Internal Medicine (2013)

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ペースメーカ心室リードによる遅発性右室心尖部穿孔の1例 | 文献情報 | J-GLOBAL 科学技術総合リンクセンター
Authors: 安恒亨, 内田孝之, 安藤廣美, 長嵜悦子, 福村文雄, 田中二郎
Journal: Circulation (2009)
Size and motion of the mitral valve annulus in man. I. A two-dimensional echocardiographic method and findings in normal subjects.
Authors: J AOrmiston, P MShah, CTei, MWong
Journal: Circulation (1981)

Using wide-angle, phased-array, two-dimensional echocardiography, mitral leaflets and their annular attachments were recorded from a view close to the standard apical four-chamber view. The transducer was rotated and recordings were made at 30 degrees rotational intervals around the circumference of the mitral valve annulus. To reconstruct the annulus, the diameters (chords) from each rotational interval were arranged around a reference point. This was done for 12 times during the cardiac cycle. Annular areas were planimetered and circumferences measured. Correlation was good for areas reconstructed and measured by the same observer on separate occasions (r = 0.963) and by two different observers (r = 0.987). In 11 normal subjects the annular area index (area divided by body surface area) increased during diastole to a maximum of 3.8 +/- 0.7 cm2/m2 (mean +/- SD) in late diastole. There was presystolic followed by systolic narrowing to a minimum in midsystole. The mean reduction in area was 26 +/- 3%. The ...
Electrophysiological delineation of the specialized A-V conduction system in patients with corrected transposition of the great vessels and ventricular septal defect.
Authors: A LWaldo, A DPacifico, L MBargeron, T NJames, J WKirklin
Journal: Circulation (1975)

The specialized atrioventricular (A-V) conduction system was electrophysiologically delineated during open-heart surgery in four patients with congenitally corrected transposition of the great vessels and associated ventricular septal defect and one patient with single ventricle. Two consistent observations were made: 1) In no case was the specialized A-V conduction system found in the right atrium, whether or not there was a coronary sinus ostium present. 2) Specialized A-V conduction system electrograms were never delineated posterior to the ventricular septal defect, in contradistinction to this usual location in hearts having ventricular septal defects associated with other congenital lesions. In three of five patients, the initial course of the A-V conduction system of the ventricles was delineated between the anterior aspect of the ventricular septal defect and the pulmonary artery. In one patient the proximal portion of the A-V conduction system was delineated on the anterior aspect of the pulmonar...
Increased endothelin in experimental heart failure.
Authors: K BMargulies, F LHildebrand, ALerman, M APerrella, J CBurnett
Journal: Circulation (1990)

Recent studies demonstrate that endothelin, a potent endogenous vasoconstrictor peptide, circulates in plasma of normal animals and humans. However, the role of this peptide in pathophysiological states remains unclear. The present study was designed to test the hypothesis that circulating endothelin concentrations are increased in experimental congestive heart failure (CHF), a pathophysiological state characterized by activation of vasoconstrictor mechanisms. In anesthetized dogs with CHF produced by 8 days of rapid ventricular pacing (n = 28), circulating plasma endothelin was increased compared with values for normal controls (n = 28; 20.4 +/- 1.4 versus 9.7 +/- 0.9 pg/ml, respectively; p less than 0.0001). A plasma endothelin level of more than 14.0 was a sensitive and specific indicator of significant CHF. Moreover, within the group with experimental CHF, right atrial pressure and pulmonary capillary wedge pressure correlated independently with circulating endothelin levels. Based on recent studies d...