tbuckley/cabot-search huggingface dataset:
Chemotherapy
Authors: David A. Karnofsky
Journal: JAMA (1965)

The optimal management of localized or regional histologically proved Hodgkin's disease (stages I and II, respectively<sup>7</sup>) is a difficult therapeutic problem because of uncertainty concerning the extent of the disease. If Hodgkin's disease can begin unifocally and then spread with varying rapidity from its site of origin to adjacent areas, it is reasonable to apply vigorous measures to try to cure the disease during its localized phase. Before undertaking a therapeutic program, it is essential to determine, as far as present techniques permit, if the disease is confined to a single area. This requires, as a minimum, a careful symptomatic history, a complete physical examination, necessary laboratory studies, which include a complete blood count, kidney and liver function tests, and certain roentgenographic procedures—chest, skeletal survey, lymphangiography of pelvic and lower abdominal areas, intravenous pyelography, and inferior vena cavography. The lymphangiogram has been particularly useful; Lee, Nelson, and Schwarz<sup>13</sup>
Pulmonary Chemodectomatosis
Authors: Frederick G. Zak, Alvaro Chabes
Journal: JAMA (1963)

FOR MANY YEARS, tumors of the carotid body occupied a unique position among the so-called nonchromaffin paragangliomas, although paraganglionic or, as we prefer to call it, glomic tissue had long been known to occur in other places, eg, in relation to the ascending aorta and the main pulmonary artery. In recent years, reports have appeared about solitary mediastinal neoplasms arising from these aortic and pulmonary glomera or from within the lung proper.<sup>1-3</sup>Glomic tissue is chemoreceptive and phylogenetically traceable to the vessels supplying gills and thus follows branchial arteries and their sensory nerves (Fig 1). The Roman numerals in the right half of the diagram show the correlation of glomic tissue with branchial arteries (I and II are hypothetical); those in the left half refer to the glossopharyngeal and vagus nerves (the nervous connections of the ciliary glomus are a matter of conjecture). The letters stand for (a) ciliary,
Is primary angioplasty the optimal treatment for acute myocardial infarction in elderly patients? Edward J. Kosinski, Bardia Asgari, Maria Capasso, Caroline Lawler, Jeffrey N. Berman, Karl Alcan, Corina Marcu, Kathleen Harper. St. Vincent's Medical Center, Bridgeport, CT
Journal: Journal of the American College of Cardiology (2001)
P1.16-21 Phase I / II Study of Carboplatin, Nab-Paclitaxel, and Concurrent Radiotherapy for Patients with Locally Advanced NSCLC
Authors: Y. Kawano, T. Sasaki, H. Yamaguchi, K. Hirano, M. Nishio, M. Satouchi, S. Hosokawa, R. Morinaga, K. Komiya, K. Inoue, Y. Fujita, R. Toyozawa, T. Kimura, K. Takahashi, K. Nishikawa, J. Kishimoto, Y. Nakanishi, I. Okamoto
Journal: Journal of Thoracic Oncology (2018)
Abstract 846: Gsk3β Inhibition Is Required For Postconditioning To Modulate Mitochondrial Permeability Transition Pore Opening
Authors: Ludovic Gomez, Abdallah Gharib, Michel Ovize
Journal: Circulation (2007)

Introduction: Activation of the PI3kinase pathway and subsequent Inhibition of GSK3β by phosphorylation at serine-9 residue has recently been shown to protect against myocardial lethal reperfusion injury. Hypothesis: We hypothesized that GSK3β may play a key role in protection afforded by postconditioning. We used transgenic mice (Tg) that express a constitutively active (i.e. that cannot be inactivated by phosphorylation at serine 9) form of GSK-3β. Methods: Anesthetized WT and Tg mice underwent 60 minutes of coronary artery occlusion followed by 24 hrs of reperfusion (n=9/gr). At reflow, mice received either no intervention (controls: C-WT and C-Tg), postconditioning (postC) by 3 cycles of [1 min ischemia / 1 min reperfusion], or an IV bolus injection (1 minute before reflow) of either 10 mg/kg of cyclosporine A (CsA), a potent inhibitor of the mitochondrial permeability transition pore (mPTP) opening, or 70μg/kg of SB 216763 (SB), a specific inhibitor of GSK3β. Infarct size (%of area at risk) was measured by TTC staining. CRC, an index of Ca 2+ -induced mPTP opening in isolated mitochondria was measured by a fluorimetric approach. Results: PostC, CsA and SB significantly reduced infarct to 29%, 36% and 34% respectively (p&lt;0.05 vs. C: 56±5%) in WT mice. In contrast, postC failed to significantly reduce infarct size in Tg mice (51±5%), while as expected CsA limited necrosis (36±6%). In WT, CRC was significantly decreased in C versus sham (75±14 nmol Ca 2+ /mg), but improved in postC, CsA and SB mice, averaging 155±31, 267±11 and 183±37 nmol Ca 2+ /mg respectively (p&lt;0.05). In Tg mice, CRC was not significantly changed in postC versus control (139±44 nmol Ca 2+ /mg), but improved in CsA. Conclusion: These results suggest that inhibition of GSK3β is involved in postconditioning’s protection against infarction, likely by preventing mPTP opening during the first minutes of reperfusion.
Fortschr Roentgenstr &amp;amp; Nuklearmed, Stuttgart
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contents
Authors: Martin Gliem, Philipp Müller, Elisabeth Mangold, Hanno Bolz, Heidi Stöhr, Bernhard Weber, Frank Holz, Peter Charbel Issa, Stephanie Hagstrom, Gui-Shuang Ying, Maureen Maguire, Daniel Martin, Research Group, Jane Gibson, Andrew Lotery, Usha Chakravarthy, Carlos Veloso, Tereza Kanadani, Frederico Pereira, Márcio Nehemy, Nakul Biscotti, Arun Singh, Laura Hope-Stone, Stephen Cpsychol, Heinrich Brown, Bertil Heimann, Peter Salmon, Vincent Daien, Annick Le Pape, Isabelle Carriere, Marianne Price, Matthew Feng, Yuri Mckee, Francis Price, Katrin Wacker, Jay Mclaren, Sejal Amin, Keith Baratz, Sanjay Patel, Esteban Fuentes, Otman Sandali, Mohamed Sanharawi, Elena Basli, Taous Hamiche, Isabelle Goemaere, Vincent Borderie, Nacim Bouheraoua, Laurent Laroche, Emilio Pedrotti, Mattia Passilongo, Adriano Fasolo, Mario Nubile, Graziella Parisi, Rodolfo Mastropasqua, Sara Ficial, Marina Bertolin, Enzo Di Iorio, Diego Ponzin, Giorgio Marchini
Journal: Ophthalmology (2015)
Monilial Vaginitis
Authors: Gordon C. Sauer
Journal: JAMA (1974)

<h3>To the Editor.—</h3> A physician asked about his recent observation of an increased incidence of monilial vaginitis in the university where he is a health officer and in the surrounding community (226:800, 1973). Dr. Donald Dukelow replied to the subject very nicely but left out some factors that should be mentioned. It has been my impression that there has been an increased incidence of monilial vaginitis in teen-age and college-age girls. A factor is the wearing of pantyhose, usually worn over or under other panties. The presence of two fabrics in this already warm and moist area predisposes it to increased heat and moisture with resultant tendency to moniliasis. Another factor arises when young girls wear a panty brief in bed under their nightgown or pajamas. This then means an additional nocturnal eight hours of more moist warmth. Thus, the change in the mode of dress has brought on a
Corrections to Numbering, Abstract, and Methods
Journal: JAMA Surgery (2017)

Sandra I. Berríos-Torres, MD; Craig A. Umscheid, MD, MSCE; Dale W. Bratzler, DO, MPH; Brian Leas, MA, MS; Erin C. Stone, MA; Rachel R. Kelz, MD, MSCE; Caroline E. Reinke, MD, MSHP; Sherry Morgan, RN, MLS, PhD; Joseph S. Solomkin, MD; John E. Mazuski, MD, PhD; E. Patchen Dellinger, MD; Kamal M. F. Itani, MD; Elie F. Berbari, MD; John Segreti, MD; Javad Parvizi, MD; Joan Blanchard, MSS, BSN, RN, CNOR, CIC; George Allen, PhD, CIC, CNOR; Jan A. J. W. Kluytmans, MD; Rodney Donlan, PhD; William P. Schecter, MD; for the Healthcare Infection Control Practices Advisory Committee
Biochemistry of Intestinal Development
Authors: Susan J. Henning
Journal: Environmental Health Perspectives (1979)

In biochemical terms, the rat small intestine is relatively immature at birth and for the first two postnatal weeks. Then during the third week a dramatic array of enzymic changes begins, and by the end of the fourth week the intestine has the digestive and absorptive properties of the adult. Selective examples of these changes are discussed with emphasis on their implications for toxicological studies. The review also includes a detailed consideration of the roles of the dietary change of weaning and of glucocorticoid and thyroid hormones in the regulation of intestinal development.
Sixth Multidiscipline Research Forum of the American Medical Association
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Just Words
Authors: Alexander Gode
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New England Journal of Medicine, Boston
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply to Diana A. Castillo-Jimenez and Herney A. García-Perdomo's Letter to the Editor re: Niranjan J. Sathianathen, Badrinath R. Konety, Fernando Alarid-Escudero, Nathan Lawrentschuk, Damien M. Bolton, Karen M. Kuntz. Cost-effectiveness Analysis of Active Surveillance Strategies for Men with Low-risk Prostate Cancer. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2018.10.055. Standardized Reporting for Economic Analyses Should be Mandatory
Authors: Niranjan J. Sathianathen, Badrinath R. Konety
Journal: European Urology (2019)
Global climate controversy
Authors: S. F. Singer
Journal: JAMA (1996)

<h3>To the Editor.</h3> —Readers of JAMA deserve a balanced account on whether global warming (because of increases in greenhouse gases) will be good or bad for human health. The article by Dr Patz and colleagues<sup>1</sup>fails to do this. First, dealing with climate science, the article presents ice core data of carbon dioxide (CO<sub>2</sub>) and temperature for the last 180 000 years (Figure 1) and notes the close correlation, implying that past increases of CO<sub>2</sub>have led to strong warming and that the current increase will do the same. This is misleading. Readers should be warned that the compressed time scale (100000 years per inch) cannot show the cases where temperature increases preceded the CO<sub>2</sub>increases. Nevertheless, one can discern a CO<sub>2</sub>increase 125 000 years ago associated with a drop in temperature. Figure 1 in the article shows a dramatic (projected) doubling of CO<sub>2</sub>, but the
Obituary Listing
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phospholipid metabolism rewiring in liver regeneration and hepatocellular carcinoma
Authors: Zoe Hall, Jack Leslie, Emma Scott, Davide Chiarugi, Evelina Charidemou, Luca Pelligrinet, Gerard Evan, Michael Allison, Antonio Vidal-Puig, Quentin Anstee, Matthew Hoare, Fiona Oakley, Julian Griffin, Michele Vacca
Journal: Journal of Hepatology (2020)
Hope and prognostic disclosure
Authors: J. W. Mack, E. F. Cook, J. Wolfe, H. E. Grier, P. D. Cleary, J. C. Weeks
Journal: Journal of Clinical Oncology (2007)

6510 Background: Physicians sometimes selectively convey prognostic information to support patients’ hopes. However, the relationship between prognostic disclosure and hope is not known. Methods: We surveyed 194 parents of children with cancer (overall response rate 70%) in their first year of cancer treatment at the Dana-Farber Cancer Institute and Children’s Hospital, Boston, Mass, and the children’s physicians. We evaluated relationships between parents’ recall of prognostic disclosure by the physician and the extent to which physician communications “always” made them feel hopeful. A five-item index of prognostic disclosure assessed whether prognostic information was provided in any form, in quantitative terms, and in written form, whether the physician gave prognostic information before the parent asked, and whether parents wanted additional prognostic information beyond what they had already received. Results: Parents were less likely to report hopeful communication when the child’s likelihood of cure was low (OR .70 per category of decreasing likelihood of cure, P=.0003). However, parents who reported having received more extensive prognostic information were more likely to report hopeful communication, even when the prognosis was poor. In a multivariable model, parental report that physician communication “always” made them feel hopeful was associated with increased prognostic disclosure (OR 1.67 per element of disclosure, P=.009) and higher perceived communication quality (OR 5.39, P&lt;.0001). In contrast, communication-related hope was inversely associated with the child’s likelihood of cure (OR .67, P=.006). Conclusions: Although physicians sometimes selectively convey prognostic information to preserve hope, we found no evidence that prognostic disclosure makes parents less hopeful. Instead, disclosure of prognosis by the physician can support hope for parents of children with cancer, even when the child’s prognosis is poor. No significant financial relationships to disclose. [Table: see text]
Environmental Standards for Ionizing Radiation: Theoretical Basis for Dose-Response Curves
Authors: Arthur C. Upton
Journal: Environmental Health Perspectives (1983)

The types of injury attributable to ionizing radiation are subdivided, for purposes of risk assessment and radiological protection, into two broad categories: stochastic effects and nonstochastic effects. Stochastic effects are viewed as probablistic phenomena, varying in frequency but not severity as a function of the dose, without any threshold; nonstochastic effects are viewed as deterministic phenomena, varying in both frequency and severity as a function of the dose, with clinical thresholds. Included among stochastic effects are heritable effects (mutations and chromosome aberrations) and carcinogenic effects. Both types of effects are envisioned as unicellular phenomena which can result from nonlethal injury of individual cells, without the necessity of damage to other cells. For the induction of mutations and chromosome aberrations in the low-to-intermediate dose range, the dose-response curve with high-linear energy transfer (LET) radiation generally conforms to a linear nonthreshold relationship and varies relatively little with the dose rate. In contrast, the curve with low-LET radiation generally conforms to a linear-quadratic relationship, rising less steeply than the curve with high-LET radiation and increasing in slope with increasing dose and dose rate. The dose-response curve for carcinogenic effects varies widely from one type of neoplasm to another in the intermediate-to-high dose range, in part because of differences in the way large doses of radiation can affect the promotion and progression of different neoplasms. Information about dose-response relations for low-level irradiation is fragmentary but consistent, in general, with the hypothesis that the neoplastic transformation may result from mutation, chromosome aberration or genetic recombination in a single susceptible cell.
Archives of Neurology, Chicago
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TOXIC PROTEIN END-PRODUCTS, THE CAUSE OF SO-CALLED INANITION FEVER
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal