tbuckley/cabot-search huggingface dataset:
Adjuvant etoposide plus cisplatin (EP) for pathologic stage (PS) II nonseminomatous germ cell tumor (NSGCT).
Authors: Deaglan Joseph McHugh, Samuel Funt, Deborah Silber, Andrea Knezevic, Sujata Patil, Devon O'Donnell, Stephanie Tsai, Victor E. Reuter, Joel Sheinfeld, Brett Stewart Carver, Robert J. Motzer, Dean F. Bajorin, George J. Bosl, Darren R. Feldman
Journal: Journal of Clinical Oncology (2018)

4552 Background: The risk of relapse after primary retroperitoneal lymph node dissection (RPLND) for patients (pts) with PS IIA NSGCT is 10-20% and increases to over 50% for pts with PS IIB NSGCT. Cisplatin-based chemotherapy reduces the risk of relapse to approximately 1%. Standard adjuvant chemotherapy regimens consist of 2 cycles of EP or 2 cycles of bleomycin plus EP (BEP). Methods: From March 1989 to April 2016, 156 pts with PS II NSGCT seen at Memorial Sloan Kettering Cancer Center and assigned to two cycles of EP chemotherapy following RPLND were included. Pts from a prior analysis (Kondagunta, JCO, 2004) were included with updated survival outcomes and expanded histopathologic parameters. Each treatment cycle consisted of cisplatin 20mg/m2 and etoposide 100mg/m2 administered on days 1 to 5 at 21-day intervals. Demographics, histopathologic features, therapeutic and survival outcomes were recorded. Results: Median age was 28 years (range 15-52). 30 pts (19%) had pN1 disease, 122 (78%) pN2 disease and 4 (3%) pN3 disease. Median number of positive lymph nodes was 3 (range 1-37) and median size of the largest positive node was 2.0cm (range 0.4-7.0cm). 69 pts (45%) had extranodal tumor extension. Embryonal carcinoma, seminoma, mature teratoma and yolk sac were the predominant histological subtypes in the RPLND pathology in 115 (90%), 8 (6%), 4 (3%) and 1 (1%) pts respectively. 150 pts (96%) received 2 cycles of EP, 5 (3%) received 1 cycle of EP and one received 4 cycles of EP due to a transient marker increase following his first cycle. Dose delays occurred in 54 (38%) pts, mostly as a result of neutropenia (44/54 delays). With a median follow-up of 9 years, two pts (1 pN2 and 1 pN3) relapsed; both achieved a CR to TIP and are NED at 65 and 143 months respectively. 3 pts died, all unrelated to GCT or treatment, for 10-year relapse-free and overall survival rates of 98% and 99%, respectively. Conclusions: This is the largest series reported to date on adjuvant chemotherapy with EP for PS II NSGCT and confirms that 2 cycles of EP is highly effective in reducing recurrence with disease-specific survival of 100% and acceptable toxicity. These data suggest that inclusion of bleomycin (e.g., BEP) in this setting is not necessary.
Lectures on the Comparative Physiology of Menstruation
Authors: A. Wiltshire
Journal: BMJ (1883)

LztuCUE II.%)*NTLBMEN,-We may now examine the evidence furnishud by ob- seration upon the females of the lower animals at their periods of heat.It will be apparent that there is singular accord in the Zsttements of competent observers upon the phenomena they present themielves in the various animals; and that, in all the crea- ture subjected to inquiry, some more or less conspicuous flux or exudation occurs; the majority exhibiting manifestations partaking in vring degrees of a sanguineous character.In observing domesticated animals, and still more those in a state of captivity, the same allowances for individual variations should be made as would be made in rogard of women; in whom we find Jaborious life and hard fare to some extent diminish the flow; while eae, luxury, and plenty (not excess) promote it.Again, racial peuliarities, with the lower animals as with the human species, may uquestionably affect the character of the flow.VeW slight changes in normal conditions affect the capacity for reproduction in all animals; hence, many creatures ail to breed in captivity, while, oa the other hand, domesticable creatures have augmented powers.Mr. Darwin's statements to this effect are .numrousand weighty.In Animate and Plants under Donestica- .tinvol.ii, pp.143-4, he says: " It would appear that any change in the habits of life, whatever these habits may be, if great enough, -tods to affect in an inexpUcable manner the powers of reproduction.The result depends more on the constitution of the species than on ;the nature of the change; for certain whole groups are affteded .-orethan others; but exceptions always occur, for some species in the most fertile groups refuse to breed, and some in the most sterile groups.breedfreely......C hsnged conditions of life have an especial ,power of acting injuriously on the reproductive system.The whole -ease is quite peculiar, for these organs, though not diseased, are thus rendered incapable of performing their proper functions, or perform them imperfectly."Ibid., p. 256: " We know that certain groups of 'organic beings, but with exceptions in each group, have their repro- *ductive systems much more easily affected by changed conditions than other groups; for instance, carnivorous birds more readly than -carnivorous mammals, and parrots more readily than pigeons; and htbis fact harmonises with the apparently capricious manner and degree which various groups of animals and plants vary under domestication."Analogous susceptibility is displayed by the human female in the' distkrbance, mostly arrest, of menstruation that so 'often attends
Respiratory symptoms and home environment in children
Authors: F Bellotto, P Chiavacci, F Laveder, A Angelini, G Thiene, R Marcolongo
Journal: Thorax (1999)

The case history is described of a young woman who presented with primary pulmonary hypertension and non-specific inflammatory signs.The patient received prolonged immunosuppressive treatment with low dose methotrexate and prednisone without any vasodilator agent.After one year the pulmonary artery pressure fell from a mean value of 47 mm Hg to 30 mm Hg and there was a corresponding clinical response.This case suggests that, in patients with pulmonary hypertension of unknown origin, immunopathogenetic factors should be sought in order to consider the utility of immunosuppressive therapy.
Global Climate Change and Infectious Diseases
Authors: Robert Shope
Journal: Environmental Health Perspectives (1991)

The effects of global climate change on infectious diseases are hypothetical until more is known about the degree of change in temperature and humidity that will occur. Diseases most likely to increase in their distribution and severity have three-factor (agent, vector, and human being) and four-factor (plus vertebrate reservoir host) ecology. Aedes aegypti and Aedes albopictus mosquitoes may move northward and have more rapid metamorphosis with global warming. These mosquitoes transmit dengue virus, and Aedes aegypti transmits yellow fever virus. The faster metamorphosis and a shorter extrinsic incubation of dengue and yellow fever viruses could lead to epidemics in North America. Vibrio cholerae is harbored persistently in the estuaries of the U.S. Gulf Coast. Over the past 200 years, cholera has become pandemic seven times with spread from Asia to Europe, Africa, and North America. Global warming may lead to changes in water ecology that could enhance similar spread of cholera in North America. Some other infectious diseases such as LaCrosse encephalitis and Lyme disease are caused by agents closely dependent on the integrity of their environment. These diseases may become less prominent with global warming because of anticipated modification of their habitats. Ecological studies will help us to understand more fully the possible consequences of global warming. New and more effective methods for control of vectors will be needed.
Gap junction's role for differential expression of ?-feioprotein and albumin 3rd Dept Int. Med., Kyoto Pref. Univ. Med., Kyoto, Japan
Journal: Hepatology (1995)

Receptor-mediated endocytosis via coated pits is modulated by the activity of protein kinases and protein phosphorylation. We examined the effects of the potent protein kinase inhibitor staurosporine (SSP) on endocytosis of the asialoglycoprotein (ASGP) receptor in HepG2 cells. Staurosporine caused a rapid (<2 min) inhibition of ligand internalization from the cell surface. In contrast the rate of receptor exocytosis from intracellular compartments to the cell surface was not altered (t12 = 8 min). This resulted in increased ASGP receptors at the plasma membrane (140% of control) while the total number of receptors per cell was unchanged. Receptor up-regulation was half-maximal at 30 nM SSP. At this concentration staurosporine also inhibited the internalization of iodinated transferrin by HepG2 cells and SK Hep-1 cells, another human hepatoma-derived cell line. Staurosporine was without effect on the non-receptor-mediated uptake of Lucifer yellow by pinocytosis. We investigated the possible involvement of protein kinase C in the inhibitory effects of staurosporine on receptor endocytosis. The active protein kinase C inhibitor H7 did not inhibit ASGP receptor internalization. Furthermore depletion of cellular protein kinase C by overnight incubation with 1 μM phorbol myristate acetate did not abrogate the SSP effect. Together these data suggest that the mechanism of SSP action is independent of the inhibition of protein kinase C. In conclusion staurosporine is a potent and rapid inhibitor of receptor trafficking which is specific for receptor internalization from the plasma membrane.
INJURIES BY RAILROAD
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SUGAR AND PROGRESS.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correspondence
Authors: Hugh McGuigan
Journal: JAMA (1913)

Ely's Liquid Cream Balm costing 00 cents contains about half n cent's worth of liquid petrolatum.Dr. Boskano's Cough and Lung Syrup Still another "new remedy for the positive cure of con- sumption, coughs, colds, etc." Ab long ago as 1008 the Kansas State Board of Health showed this remedy to be niisbianded, describing it as "a saccharin solution of expec- torant drugs with tar and chloroform."In 1011 it was
Catheter-Fever
Authors: J. Niven
Journal: BMJ (1884)

THE .PRRJTISH MED2WL- JOURN.AL but the patient's temperature and pulse had fallen to 990 and 100 respectively; and, beyond a little sickness and slight pain, her con- dition was most comfortable.This putrid discharge continued for several days; but Mrs. S.'s convalescence was steady, and I ceased attending her on August 17th, leaving her, as I hope, radically cured of her rupture, although she will, as a measure of precaution, wear a truss.Among all the advances in abdominal surgery of the present day, drainage by means of large tubes stands, I think, preeminent.Case Ix, ovariotomy, was a very simple case.The tumour was of the left ovary.The right I found slightly enlarged by several small and thin-walled cysts, and I therefore removed it also, although it is questionable whether it would have taken harm if left.No tube was used, and, by the end of the second week, the patient appeared well, but recovery was hindered by inflammation round the stump of this ovary.The temperature rose on the fourteenth day, the bowels ceased acting, and there was sickness.Further exudation could be felt in the right iliac fossa.The lump, however, disappeared on the twentieth day, synchronously with a fall of temperature; but there was no evidence of any discharge of pus.Case x, ovariotomy, is interesting chiefly on account of the youth of the patient.I saw her first in the end of February.I found a tumour rather high in the abdomen, which I diagnosed to be ovarian.This interfered but little with the child's comfort, although it gradually increased in size.In the beginning of August, she had slight peritonitis, and on the 13th of September ovariotomy was performed.The tumour was made up of so many thick-walled cysts, that it was not possible to lessen its bulk as much as usual before removing it, and I had therefore to enlarge the abdominal
A double-blind trial of oral progesterone, alprazolam, and placebo in treatment of severe premenstrual syndrome
Authors: E. W. Freeman
Journal: JAMA (1995)

<h3>Objective.</h3> —To determine the effectiveness of oral micronized progesterone, alprazolam, and placebo in premenstrual syndrome (PMS) treatment and the effect of clinical contact on treatment responses. <h3>Design.</h3> —Randomized, double-blind, placebo-controlled 3-month parallel treatment arms with flexible dosage and with the length of clinical contact randomized within each treatment group. <h3>Setting.</h3> —University hospital PMS medical treatment outpatient program in obstetrics/gynecology department. <h3>Subjects.</h3> —Among volunteers for PMS treatment, 444 were evaluated and 185 meeting defined PMS criteria were randomized to treatment; treatment data are available for 170. There were no medical withdrawals for adverse events. <h3>Intervention.</h3> —A double-blinded protocol in which 300 mg of oral micronized progesterone, 0.25 mg of alprazolam, or placebo was administered four times a day from day 18 of the menstrual cycle through day 2 of the next cycle, including taper. The mean daily dose at the third treatment was 1760 mg of progesterone or 1.5 mg of alprazolam. Subjects were randomized to brief (&lt;20 minutes) or extended (50 minutes) visits. <h3>Main Outcome Measures.</h3> —Daily symptom report (DSR) scored for total DSR symptoms, four DSR factors. <h3>Results.</h3> —Alprazolam was significantly better than placebo or progesterone for total premenstrual symptoms and DSR factors of mental function, pain, and mood. Thirty-seven percent of the alprazolam group experienced a 50% reduction in total DSR scores. There were no clinically significant withdrawal symptoms when alprazolam administration was restricted to the luteal phase. Oral micronized progesterone therapy was no better than placebo. Brief vs extended visits had no effect on treatment outcome. Treatment response was associated with severity of premenstrual symptoms at baseline but with no other diagnostic variables. <h3>Conclusions.</h3> —Alprazolam has a role in PMS treatment and offers a therapy limited to the luteal phase. Oral micronized progesterone is ineffective for PMS. (<i>JAMA</i>. 1995;274:51-57)
Overdose Treatment
Authors: Richard E. Kaufman
Journal: JAMA (1974)

One hundred addicts were questioned about their methods of recognizing and treating opiate overdosage. They described three categories of treatment: external stimulants, "intravenous homemades," and intravenously given pharmacologics. These remedies were at variance with accepted medical therapy. In addition, where they may have some efficacy in borderline cases, any benefits are outweighed by the possibility of exacerbating the overdose effects. These treatments may also contribute to addict morbidity in the form of aspiration, infection, and trauma.
Memorials to the late Dr. Leidy.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Good Fortunes
Authors: Jenna Smith
Journal: Annals of Internal Medicine (2019)

Ad Libitum19 March 2019Good FortunesJenna SmithJenna SmithRichmond, Texas (J.S.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M18-2945 Audio Reading - “Good Fortunes” Audio. Virginia Hood, MD, reads “Good Fortunes” by Jenna Pashley Smith Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In the specialist's waiting room,plastic joints open like fortune cookiesto reveal my body's capacity for self-destruction.The doctor is brusque and precise.Name: Rheumatoid ArthritisCause and cure: UnknownI am still a teenager, too bent with anxiety to cry.The drug company's sleek brochures calm my fearsuntil I turn to the back page, littered with fine print.Caution: side effects include tuberculosis,cancer, obscure fungal infections, and total baldness.In context, my current trials seem trivial.Swollen hands dismember the prescription asI am initiated into the desperation of the chronically ill.Wading past documented dangers, I choose to swim inuncharted waters. Without warning labels,... Author, Article, and Disclosure InformationAffiliations: Richmond, Texas (J.S.)Current Author Address: Jenna Pashley Smith; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement Audio Reading - “Good Fortunes” Audio. Virginia Hood, MD, reads “Good Fortunes” by Jenna Pashley Smith Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 19 March 2019Volume 170, Issue 6Page: 420KeywordsDietDrugsFatsFearInternetKneesPharynxResearch laboratoriesRheumatoid arthritisTuberculosis ePublished: 19 March 2019 Issue Published: 19 March 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Phospholipase A<SUB>2</SUB> augments contraction and intracellular calcium mobilization through thromboxane A<SUB>2</SUB> in bovine tracheal smooth muscle
Authors: Y. Takata, Y. Nishimura, H. Maeda, M. Yokoyama
Journal: European Respiratory Journal (1999)

A series of monoclonal antibodies which bind to a mucin known as M1 (anti-M1 MAbs) have also been shown to detect the product of the human gene MUC5AC. The aim of this investigation was to determine the concentration of the M1 mucin in the surface epithelium of human bronchial preparations by means of immunohistochemistry and in the bronchial fluid derived from human airways by means of an immunoradiometric assay. Human bronchial ring preparations from the resection material of 20 patients were challenged with methacholine, leukotriene D4, or anti-immunoglobulin E. Experiments were performed in preparations with an intact epithelium as well as in tissues in which the epithelium had been mechanically removed. The anti-M1 MAbs stained the goblet cells in the epithelium intensely and there was also light and less uniform staining in the submucosa. The M1/MUC5AC mucin in the fluids secreted by the bronchial preparations was not modified during either the experimental protocol or stimulation with the different secretagogues. However, in preparations in which the epithelium had been removed, there was a significant reduction in the amount of M1/MUC5AC mucin detected. These data suggest that the M1/MUC5AC mucin detected in the biological fluids produced by human airways in vitro may be released constantly, and principally from the goblet cells in the epithelial layer.
Of breath and spirits
Authors: J. S. Gravenstein
Journal: JAMA (1981)

WORDS are like pots. In their forms, both show their background and culture and both serve as containers. Some old pots, now smooth and shiny on their outside from daily use, still hold traces of ancient residue on the inside. It is similar with some very old words in our language: they still carry the flavor of ancient concepts they conveyed in bygone centuries. Words dealing with respiration and spirits provide an example. Common human experience links breath to life and life to spiritual values. For the Judeo-Christian world, Genesis 2:7 exemplifies this link: "And the Lord God formed man of the dust of the ground and breathed into his nostrils the breath of life; and man became a living soul." Here the Divine breath initiates life. Later, philosophers and physicians thought about this vital force, named it, and tried to identify it. In 1795, J. C. Reil, a German