tbuckley/cabot-search huggingface dataset:
Getting bugs out of military operations is job of environmental health specialty team
Authors: C. Marwick
Journal: JAMA (1989)

WHEN THE US MARINES were sent into Lebanon in 1958, more than 55% of that force became ill from contaminated food or water, or from insect-borne diseases. But when they again were sent to Lebanon in 1982, the troops had only a 2% morbidity from these environmentally associated illnesses during the 21 months they served there. Playing a major role in reducing the illness rate when the Marines returned was a group of experts, including an environmental health officer, an entomologist, and several preventive medicine technicians combined into what is called a "Mobile Medical Augmentation Readiness Team." The US Navy has 10 such teams. "In 1982, in that Marine encampment in Lebanon, we took care of our water, we made sure we had good clean food, we saw to it that refuse was disposed of properly, and we kept the fly population down," says Douglas A. Ehrhardt, PhD, a US
Genetics of Recurrent Early-Onset Major Depression (GenRED): Final Genome Scan Report
Authors: Peter Holmans
Journal: American Journal of Psychiatry (2007)

Objective: The authors carried out a genomewide linkage scan to identify chromosomal regions likely to contain genes that contribute to susceptibility to recurrent early-onset major depressive disorder, the form of the disorder with the greatest reported risk to relatives of index cases. Method: Microsatellite DNA markers were studied in 656 families with two or more such cases (onset before age 31 in probands and age 41 in other relatives), including 1,494 informative “all possible” affected relative pairs (there were 894 independent affected sibling pairs). Analyses included a primary multipoint allele-sharing analysis (with ALLEGRO) and a secondary logistic regression analysis taking the sex of each relative pair into account (male-male, male-female, female-female). Results: Genomewide suggestive evidence for linkage was observed on chromosome 15q25-q26 (at 105.4 centimorgans [cM]). The authors previously reported genomewide significant linkage in this region in the first 297 families. In the secondary analysis, after empirical genomewide correction for multiple testing, suggestive linkage results were observed on chromosome 17p12 (28.0 cM, excess sharing in male-male and male-female pairs) and on chromosome 8p22-p21.3 (25.1 cM, excess sharing in male-male pairs). Conclusions: These regions of chromosomes 15q, 17p, and 8p might contain genes that contribute to susceptibility to major depression and related disorders. Evidence for linkage has been reported independently in the same regions of chromosome 15q for major depression and of chromosome 8p for related personality traits.
PLoS Medicine Issue Image | Vol. 2(4) April 2005
Journal: PLoS Medicine (2005)

John Patrick McKenzie is a visual poet—a writer and artist creating striking images utilizing text as the sole formal element. His words are powerful statements from his inner world and interpretations of what is occurring in his immediate community, as well as the rich landscape of popular culture and global politics. John expresses himself on paper, plexiglass, wood, glass, found objects, and furniture using markers, colored pens, watercolors, acrylics, and cray-pas. John has created a unique lettering style of open and closed spaces. His word collages may be read in any direction, from any starting point, and multiple meanings may be found in the variety of ways the words interact. He has exhibited nationally and internationally. PLoS Medicine asked John, who is autistic, what he thought of the state of health care and he created this piece in response. It speaks to disease caused by environmental pollution, the personal experience of illness, and the prohibitive cost of medication. John was born in 1962 in the Philippines. He moved to the United States with his family in 1964 and currently lives in San Francisco's Mission District. Since 1989, he has been making art at Creativity Explored, a non-profit visual arts center in San Francisco, where artists with developmental disabilities create, exhibit, and sell art. Creativity Explored provides studio space, materials, and instruction for 125 artists working in a wide range of media. To learn more, visit www.creativityexplored.org Image Credit: John Patrick McKenzie
Incorrect Values
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CASES IN MIDWIFERY
Authors: T. Radford
Journal: BMJ (1856)

as VA as th exteral wond), he gradually oak, and died aout thr mnths after the opertion.-Poe iwtAm examination showed the ileum and colon, ter- nati3 g separately in the wound, the mucous membrane of te stn@ being oontinuous with the rest of the wound, so as to shut off the cavity of the gut from that of the peitoneum.
"IS CODEIN A HABIT-FORMING DRUG?"
Journal: JAMA (1922)

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Books Received
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EP1.14-18 NGS-Molecular Characterization of Lung Adenocarcinomas from Hispanic Patients: Level of Evidence for Therapeutic Actionability
Authors: O.G. Arrieta, R. Gerson, C. Blanco, J. Alexander Meza, A. Silva, S. Rivera Rivera, C. Zuloaga Fernández, M. Lazaro, E. Kazakova, A. Villa
Journal: Journal of Thoracic Oncology (2019)
Miscellany
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MEDICAL PREPAREDNESS
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RATS IN RELATION TO PLAGUE
Authors: B. Skinner
Journal: BMJ (1905)

THE connexion of domestic rats with plague requires for its elucidation some further remarks on 'the distribution and life history of the tick, iyalomma aegyptium, and also on the cattle diseases referred to on p. 624 of the BRITISH MEDICAL JOURNAL.It is necessary to mention certain points indicative of the possibility of the transference of a cattle-Eeuche to rats and men by the agency of ticks.Although Burmah has up to the preeent not suffered severely from plague, the more recent returns indicate a ten- dency to invasion of that province.It will be intereating to note if this invasion coincides with an invasion of H. aegyptium, which has hitherto not been found in Burmah, although several species of ticks from that country have been recorded by Professor Neumann.Dr. YersinI records plague as e-xisting in Yunnan from March to July yearly since 187x.Previous to that date the record is not reliable, but tradition points to outbreaks of plague having occurred in Yunnan frequently in the past.It has been obeerved above that H. aegyptium has
FORMALDEHYDE DISINFECTION.
Authors: W. K. JAQUES
Journal: JAMA (1900)

In formaldehyde we have a most valuable agent with which to control and destroy infectious germs, but the properties of this gas and its effects on living cells must be understood to apply it within its limitations. It is a well-known fact that, even in small quantities, it has a peculiar effect on fibrin, hardening and otherwise changing its physical properties. A small amount added to egg albumin or blood serum so changes them that they will not coagulate on heating. To the power of this gas to penetrate the cell wall of bacteria and alter its properties are we indebted for its germicidal qualities. The destructive power of many pathogenic germs depends on their ability to multiply rapidly and overwhelm their host before resisting forces can be brought to bear. But it is a universal law of Nature that things of rapid growth are also of delicate structure, and
Abstract A36: TP53 loss creates therapeutic vulnerability in colorectal cancer
Authors: Yunhua Liu, Xiongbin Lu
Journal: Clinical Cancer Research (2017)

Abstract TP53, a well-known tumor suppressor gene, is frequently inactivated by mutation or deletion in a majority of human tumors. A tremendous effort has been made to restore p53 activity in cancer therapies. However, no effective p53-based therapy has been successfully translated into clinical cancer treatment due to the complexity of p53 regulators and their poor drugability. Here, we demonstrate that genomic deletion of TP53 frequently encompasses neighboring essential genes, rendering cancer cells with hemizygous TP53 deletion vulnerable to further suppression of such genes. POLR2A is identified as such an essential house-keeping gene that is virtually co-deleted with TP53 in many types of human cancer. It encodes the largest and catalytic subunit of RNA polymerase II complex, which is specifically inhibited by α-amanitin. Our analysis of clinical samples and cancer cell lines in The Cancer Genome Atlas (TCGA) and Cancer Cell Line Encyclopedia (CCLE) reveals that POLR2A expression levels are tightly correlated with its gene copy numbers in human colorectal tumors. Suppression of POLR2A with α-amanitin or short-hairpin RNAs, selectively inhibits proliferation, survival and tumorigenic potential of colorectal cancer cells with hemizygous TP53 loss in a p53-independent manner. Previous clinical applications of α-amanitin have been limited due to its liver toxicity. However, we found that α-amanitin-based antibody drug conjugates (ADCs) are highly effective therapeutic agents with dramatically reduced toxicity. Here, we show that low doses of α-amanitin-conjugated anti-EpCAM (Epithelial Cell Adhesion Molecule) antibody lead to complete tumor regression in murine models of human colorectal cancer with hemizygous deletion of POLR2A. We anticipate that inhibiting POLR2A will be a novel therapeutic approach for cancers harboring such common genomic alterations. Note: This abstract was not presented at the conference. Citation Format: Yunhua Liu, Xiongbin Lu. TP53 loss creates therapeutic vulnerability in colorectal cancer. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Targeting the Vulnerabilities of Cancer; May 16-19, 2016; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2017;23(1_Suppl):Abstract nr A36.
Jaundice due to hepatitis A virus.
Journal: BMJ (1981)

Gastroenteritis in developing countriesIn developing countries the continuation of breast-feeding may be essential for survival.Although infants who are completely breast-fed rarely have severe gastroenteritis weaning foods made up with water may infect a breast-fed infant.These infants can be managed by continuing the breast-feeding and supplementing the fluid intake to prevent dehydration until the infant spontaneously recovers.Supplements may be given by mouth in mild cases and intravenously in severe cases.An easier method is to give them by continuous intragastric infusion, for which the fluid does not have to be sterile.Oral rehydrating fluids can be made up using specially designed spoons to measure the sugar and salt.Mothers and older siblings can be taught to use this mixture at the beginning of an episode of diarrhoea rather than ~~~wait until the child is dehydrated.Simple slogans such as "a cup of fluid for every stool" are effective.
Syncope
Authors: Wishwa N. Kapoor
Journal: New England Journal of Medicine (2000)

Syncope is a sudden and brief loss of consciousness associated with a loss of postural tone, from which recovery is spontaneous. The pathophysiology of all forms of syncope consists of a sudden decrease in or brief cessation of cerebral blood flow. Syncope is common, disabling, and possibly associated with a risk of sudden death, but its causes are difficult to diagnose.13 Consequently, syncope often leads to hospital admission, multiple consultations, and the performance of many diagnostic tests.4 This article provides an approach to the evaluation of syncope.Is It Syncope?The first important issue is distinguishing syncope from several . . .
Délimitation de l’étendue des cancers gastriques superficiels par imagerie à bande spectrale étroite avec magnification (M-NBI) et chromoendoscopie: une étude multicentrique randomisée controlee
Journal: Endoscopy (2018)

Introduction: la délimitation exacte des marges tumorales est nécessaire pour la résection curative des cancers gastriques superficiels (CGS). L’objectif de cette étude multicentrique randomisée contrôlée était de comparer la précision avec laquelle l’imagerie à bande spectrale étroite avec magnification (M-NBI) et la chromoendoscopie à l’indigo carmin permettaient de délimiter les marges des CGS.
Archives of Neurology, Chicago
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comprehensive Gynecology
Authors: Allan G. Charles
Journal: JAMA (1997)

<b>Comprehensive Gynecology Review</b>, by Frank W Ling, Louis A. Vontver, Roger P. Smith, and Sharon T. Phelan, 3rd ed, 277 pp, with illus, paper, $33.95, ISBN 0-8151-5512-3, St Louis, Mosby, 1997. The third edition of<i>Comprehensive Gynecology</i>by Mishell, Stenchever, Droegemueller, and Herbst is an out-standing review of the entire field and a monumental effort by four distinguished authors. The book has five parts: "Basic Sciences," "Comprehensive Evaluation of the Female," "General Gynecology," "Gynecologic Oncology," and "Reproductive Endocrinology and Infertility." Each author brings his special expertise to this comprehensive edition. Any resident studying for the boards or any practicing physician who wants to update or refresh knowledge on any aspect of current practices in gynecology would do well to read this outstanding volume. Particularly effective are the "Key Terms and Definitions" that begin each chapter. Also, each chapter ends with a summary of key points and has an alphabetical bibliography.
May 24, 2000
Journal: JAMA (2000)

Ken Nagaya, MD; Michael D. Fetters, MD, MPH, MA; Mutsuo Ishikawa, MD; Takahiko Kubo, MD; Takashi Koyanagi, MD; Yoshiharu Saito, MD; Hiroshi Sameshima, MD; Mitsuhiro Sugimoto, MD; Koichiro Takagi, MD; Yoshihide Chiba, MD; Hiroshi Honda, MD; Masaaki Mukubo, MD; Mitsuhiro Kawamura, MD; Shoji Satoh, MD; Reiko Neki, MD
PARIS
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOCIETY PROCEEDINGS.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal