tbuckley/cabot-search huggingface dataset:
QUADAS-C: A Tool for Assessing Risk of Bias in Comparative Diagnostic Accuracy Studies
Authors: Bada Yang, Sue Mallett, Yemisi Takwoingi, Clare F. Davenport, Christopher J. Hyde, Penny F. Whiting, Jonathan J. Deeks, Mariska M.G. Leeflang
Journal: Annals of Internal Medicine (2021)

Comparative diagnostic test accuracy studies assess and compare the accuracy of 2 or more tests in the same study. Although these studies have the potential to yield reliable evidence regarding comparative accuracy, shortcomings in the design, conduct, and analysis may bias their results. The currently recommended quality assessment tool for diagnostic test accuracy studies, QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies-2), is not designed for the assessment of test comparisons. The QUADAS-C (Quality Assessment of Diagnostic Accuracy Studies-Comparative) tool was developed as an extension of QUADAS-2 to assess the risk of bias in comparative diagnostic test accuracy studies. Through a 4-round Delphi study involving 24 international experts in test evaluation and a face-to-face consensus meeting, an initial version of the tool was developed that was revised and finalized following a pilot study among potential users. The QUADAS-C tool retains the same 4-domain structure of QUADAS-2 (Patient Selection, Index Test, Reference Standard, and Flow and Timing) and comprises additional questions to each QUADAS-2 domain. A risk-of-bias judgment for comparative accuracy requires a risk-of-bias judgment for the accuracy of each test (resulting from QUADAS-2) and additional criteria specific to test comparisons. Examples of such additional criteria include whether participants either received all index tests or were randomly assigned to index tests, and whether index tests were interpreted with blinding to the results of other index tests. The QUADAS-C tool will be useful for systematic reviews of diagnostic test accuracy addressing comparative questions. Furthermore, researchers may use this tool to identify and avoid risk of bias when designing a comparative diagnostic test accuracy study.
Delivery of MiR335‐5p‐Pendant Tetrahedron DNA Nanostructures Using an Injectable Heparin Lithium Hydrogel for Challenging Bone Defects in Steroid‐Associated Osteonecrosis
Authors: Donghai Li, Zhouyuan Yang, Yue Luo, Xin Zhao, Meng Tian, Pengde Kang
Journal: Advanced Healthcare Materials (2021)

Corticosteroids-induced Dickkopf-1 (DKK1) upregulation and Wnt signaling inhibition result in bone metabolism disorder and steroid-associated osteonecrosis (SAON). Implanting biomaterials to regulate the Wnt pathway is a promising method to repair challenging bone defects associated with SAON. Here, tetrahedral DNA nanostructures (TDNs) are fabricated as gene carriers to deliver MiR335-5p, which targets DKK1 translation. Heparin lithium hydrogel (Li-hep-gel) is synthesized to act as a lithium and MiR@TDNs delivery agent. Finally, the repair effects on challenging bone defect in SAON using a MiR@TDNs/Li-hep-gel composite are assessed in vivo. The results reveal that MiR@TDNs are absorbed by bone mesenchymal stem cells (BMSCs) and increase cell viability and reduce apoptosis. Moreover, MiR@TDNs promote alkaline phosphatase expression and calcium nodular deposition, decrease lipid droplet expression of BMSCs, and improve vascular endothelial growth factor secretion and vascular-like structure formation in vitro. After MiR@TDNs/Li-hep-gel is implanted into the SAON model, the internal bone defect of osteonecrosis is repaired with a large area of new bone accompanied with neovascularization and reduced empty lacunae. In conclusion, MiR@TDNs/Li-hep-gel can provide dual delivery of lithium and MiR@TDNs, which synergistically upregulate the Wnt signaling pathway, enhancing bone regeneration in challenging bone defects, and can be potentially used in SAON repair.
Association of COVID-19 With New Waiting List Registrations and Liver Transplantation for Alcoholic Hepatitis in the United States
Authors: Maia S. Anderson, Valeria S. M. Valbuena, Craig S. Brown, Seth A. Waits, Christopher J. Sonnenday, Michael Englesbe, Jessica L. Mellinger
Journal: JAMA Network Open (2021)

ResultsA total of 51 488 new waiting list registrations and 32 320 DDLTs from January 1, 2016, to January 31, 2021, were assessed.The median (IQR) age was 58.0 (50-64) years among pre-COVID-19 waiting list registrants and liver transplant recipients.The median (IQR) age was 58.0 (49-64) years for new waiting list registrants during COVID-19 and 58.0 (48-64) years for transplant recipients during COVID-19.Among new waiting list registrants, 15 247 (36.1%) were women and 26 930 (63.9%) were
Personalized and Programmable Microneedle Dressing for Promoting Wound Healing
Authors: Yuqiu Wang, Huihui Lu, Maoze Guo, Jianlin Chu, Bingbing Gao, Bingfang He
Journal: Advanced Healthcare Materials (2021)

Microneedle (MN) dressings, with the ability of transdermal drug delivery, have played an essential role in the field of wound healing. However, patients may still feel uncomfortable when sensitive unhealing wounds are pieced by strong needles. Here, inspired by the structure of mosquito mouthparts, which possess a fixation part and a liquid-transferring part, we present a novel MN wound dressing with superfine needle tips, personalized pattern design, programmable needle length, and multiple mechanical strengths for intelligent and painless drug delivery. By simply stretching the silicone rubber (Ecoflex) molds before engraving, superfine MNs can be formed in the restored molds. Meanwhile, by utilizing intelligent image recognition, precise treatment for irregular wounds is achieved. Notably, combined with temperature-responsive N-isopropylacrylamide (NIPAM) hydrogel and inverse opal (IO) photonic crystals (PCs), a controllable drug release system has been achieved on MN dressings. Moreover, the performance of the MN dressing in facilitating wound recovery has been demonstrated by full-thickness skin wounds of a mouse model. These results indicate that novel personalized and programmable MN wound dressings are of considerable value in the field of wound management.
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses
Authors: Mohamad-Gabriel Alameh, István Tombácz, Emily Bettini, Katlyn Lederer, Sonia Ndeupen, Chutamath Sittplangkoon, Joel R. Wilmore, Brian T. Gaudette, Ousamah Y. Soliman, Matthew Pine, Philip Hicks, Tomaz B. Manzoni, James J. Knox, John L. Johnson, Dorottya Laczkó, Hiromi Muramatsu, Benjamin Davis, Wenzhao Meng, Aaron M. Rosenfeld, Shirin Strohmeier, Paulo J.C. Lin, Barbara L. Mui, Ying K. Tam, Katalin Karikó, Alain Jacquet, Florian Krammer, Paul Bates, Michael P. Cancro, Drew Weissman, Eline T. Luning Prak, David Allman, Botond Z. Igyártó, Michela Locci, Norbert Pardi
Journal: Immunity (2021)
TCT-435 Validation of In Vivo Prosthetic Mitral Regurgitation Quantification Using a Novel Videodensitometric Angiographic Platform by In Vitro Mock Circulation
Authors: Hideyuki Kawashima, Patrick Serruys, Rodrigo Modolo, Yoshinobu Onuma, Osama Soliman
Journal: Journal of the American College of Cardiology (2021)
Abstract 15309: The 5-HT2A Receptor Antagonist Sarpogrelate Suppresses Pressure Overload-Induced Development of Heart Failure in Mice
Authors: Kana Shimizu, Masafumi Funamoto, Yoichi Sunagawa, Yasufumi Katanasaka, Yusuke Miyazaki, Noriyuki Murai, Hiroki Honda, Satoshi Shimizu, Nurmila Sari, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto
Journal: Circulation (2019)

Purpose: Seretonin (5-HT), a neurohormone involved in a wide range of physiological functions, has generated much interest in recent years regarding its potential role in cardiac function; however,...
TCT-125 Incidence and Outcomes of Cardiogenic Shock Among Women With Spontaneous Coronary Artery Dissection
Authors: Mohammed Osman, Moinuddin Syed, Timothy Simpson, Bhaskar Bhardwaj, Babikir Kheiri, Punag Divanji, Harsh Golwala, Firas Zahr, Joaquin Cigarroa
Journal: Journal of the American College of Cardiology (2021)
TCT-173 FFR-Guided PCI Optimization Directed by High-Definition Intravascular Ultrasound: Baseline Findings From the FFR REACT Trial
Authors: Tara Neleman, Laurens Zandvoort, Maria Tovar Forero, Kaneshka Masdjedi, Jurgen Ligthart, Karen Witberg, Mattie Lenzen, Eric Boersma, Wijnand den Dekker, Roberto Diletti, Jeroen Wilschut, Peter de Jaegere, Felix Zijlstra, Nicolas van Mieghem, Joost Daemen
Journal: Journal of the American College of Cardiology (2021)
ドナー白血球輸血(DLT)による致命的移植片対宿主病(GVHD)が移植後急性白血病の再発に及ぼす移植片対白血病(GVL)効果:2症例の報告
Authors: Takahashi S, Nagayama H, Nagamura F, Inoue T, Okamoto S, Tani K, Ikebuchi K, Sato N, Ozawa K, Hirano T, Oshimi K, Asano S
Journal: Blood (1994)
The 2021 WHO Classification of Tumors of the Thymus and Mediastinum: What Is New in Thymic Epithelial, Germ Cell, and Mesenchymal Tumors?
Authors: Alexander Marx, John K.C. Chan, Lara Chalabreysse, Sanja Dacic, Frank Detterbeck, Christopher A. French, Jason L. Hornick, Hiroshi Inagaki, Deepali Jain, Alexander J. Lazar, Mirella Marino, Edith M. Marom, Andre L. Moreira, Andrew G. Nicholson, Masayuki Noguchi, Daisuke Nonaka, Mauro G. Papotti, Stefan Porubsky, Lynette M. Sholl, Hisashi Tateyama, Vincent Thomas de Montpréville, William D. Travis, Arun Rajan, Anja C. Roden, Philipp Ströbel
Journal: Journal of Thoracic Oncology (2021)

This overview of the fifth edition of the WHO classification of thymic epithelial tumors (including thymomas, thymic carcinomas, and thymic neuroendocrine tumors [NETs]), mediastinal germ cell tumors, and mesenchymal neoplasms aims to (1) list established and new tumor entities and subtypes and (2) focus on diagnostic, molecular, and conceptual advances since publication of the fourth edition in 2015. Diagnostic advances are best exemplified by the immunohistochemical characterization of adenocarcinomas and the recognition of genetic translocations in metaplastic thymomas, rare B2 and B3 thymomas, and hyalinizing clear cell carcinomas. Advancements at the molecular and tumor biological levels of utmost oncological relevance are the findings that thymomas and most thymic carcinomas lack currently targetable mutations, have an extraordinarily low tumor mutational burden, but typically have a programmed death-ligand 1high phenotype. Finally, data underpinning a conceptual advance are illustrated for the future classification of thymic NETs that may fit into the classification scheme of extrathoracic NETs. Endowed with updated clinical information and state-of-the-art positron emission tomography and computed tomography images, the fifth edition of the WHO classification of thymic epithelial tumors, germ cell tumors, and mesenchymal neoplasms with its wealth of new diagnostic and molecular insights will be a valuable source for pathologists, radiologists, surgeons, and oncologists alike. Therapeutic perspectives and research challenges will be addressed as well.
A nationwide study of the incidence and trends of first and multiple basal cell carcinomas in the Netherlands and prediction of future incidence*
Authors: K. Schreuder, L. Hollestein, T.E.C. Nijsten, M. Wakkee, M.W.J. Louwman
Journal: British Journal of Dermatology (2021)

Basal cell carcinoma (BCC) is the most frequently diagnosed malignancy worldwide and an ever increasing annual incidence is observed. However, nationwide registries of BCCs are very rare, and often extrapolation of the data has been necessary to estimate the absolute number of diagnoses. As of September 2016, all histopathologically confirmed BCCs are registered in the Netherlands, due to developments in automatic notification and import in the Netherlands Cancer Registry. This offers the unique possibility to assess the nationwide population-based incidence of first and multiple BCCs.To assess the nationwide incidence and trends of first and multiple BCCs in the Netherlands and to predict incidence rates up to 2029.All patients with histopathologically confirmed BCC between 2001 and 2019 were selected from the population-based Netherlands Cancer Registry. Age-standardized incidence rates were calculated and trends were analysed with use of the estimated annual percentage change. Prediction of BCC incidence rates up to 2029 was based on a regression model.In total, 601 806 patients were diagnosed with a first BCC over the period 2001-2019. The age-standardized incidence rates for both men and women with a first BCC increased over these years, from 157 to 304 and from 124 to 274 per 100 000 person-years, respectively. For male and female patients aged 30-39 years, decreases in annual incidences of -3·6% and -3·0%, respectively, were found in recent years. For patients aged 50 years or older an ever increasing trend was found. One-quarter of the patients with a first primary BCC developed one or more subsequent BCCs within 3 years. Increases in incidence of 30·4% (male) and 25·3% (female) are expected in the next 10 years.BCC incidence has doubled over the past two decades. Trends have seemed to stabilize in recent years for patients aged < 50 years. This might be a first sign of a decreasing trend. The incidence continues to rise in patients aged 50 years and older. In the next decade a further increase in BCC incidence is expected.
Trends in Outpatient Care for Medicare Beneficiaries and Implications for Primary Care, 2000 to 2019
Authors: Michael L. Barnett, Asaf Bitton, Jeff Souza, Bruce E. Landon
Journal: Annals of Internal Medicine (2021)

Despite the central role of primary care in improving health system performance, there are little recent data on how use of primary care and specialists has evolved over time and its implications for the range of care coordination needed in primary care.
TCT-372 The Prevalence and Inpatient Outcomes of ST-Elevation Myocardial Infarction in the Absence of Traditional Modifiable Cardiovascular Risk Factors: A National Inpatient Analysis
Authors: Garba Rimamskep Shamaki, Israel Safiriyu, Chimezie Mbachi, Mercy Anyanwu, Sanjana Nagraj, David Corteville, Richard Alweis
Journal: Journal of the American College of Cardiology (2021)
2021 Dietary Guidance to Improve Cardiovascular Health: A Scientific Statement From the American Heart Association
Authors: Alice H. Lichtenstein, Lawrence J. Appel, Maya Vadiveloo, Frank B. Hu, Penny M. Kris-Etherton, Casey M. Rebholz, Frank M. Sacks, Anne N. Thorndike, Linda Van Horn, Judith Wylie-Rosett
Journal: Circulation (2021)

Poor diet quality is strongly associated with elevated risk of cardiovascular disease morbidity and mortality. This scientific statement emphasizes the importance of dietary patterns beyond individual foods or nutrients, underscores the critical role of nutrition early in life, presents elements of heart-healthy dietary patterns, and highlights structural challenges that impede adherence to heart-healthy dietary patterns. Evidence-based dietary pattern guidance to promote cardiometabolic health includes the following: (1) adjust energy intake and expenditure to achieve and maintain a healthy body weight; (2) eat plenty and a variety of fruits and vegetables; (3) choose whole grain foods and products; (4) choose healthy sources of protein (mostly plants; regular intake of fish and seafood; low-fat or fat-free dairy products; and if meat or poultry is desired, choose lean cuts and unprocessed forms); (5) use liquid plant oils rather than tropical oils and partially hydrogenated fats; (6) choose minimally processed foods instead of ultra-processed foods; (7) minimize the intake of beverages and foods with added sugars; (8) choose and prepare foods with little or no salt; (9) if you do not drink alcohol, do not start; if you choose to drink alcohol, limit intake; and (10) adhere to this guidance regardless of where food is prepared or consumed. Challenges that impede adherence to heart-healthy dietary patterns include targeted marketing of unhealthy foods, neighborhood segregation, food and nutrition insecurity, and structural racism. Creating an environment that facilitates, rather than impedes, adherence to heart-healthy dietary patterns among all individuals is a public health imperative.
The Lancet and Financial Times Commission on governing health futures 2030: growing up in a digital world
Authors: Ilona Kickbusch, Dario Piselli, Anurag Agrawal, Ran Balicer, Olivia Banner, Michael Adelhardt, Emanuele Capobianco, Christopher Fabian, Amandeep Singh Gill, Deborah Lupton, Rohinton P Medhora, Njide Ndili, Andrzej Ryś, Nanjira Sambuli, Dykki Settle, Soumya Swaminathan, Jeanette Vega Morales, Miranda Wolpert, Andrew W Wyckoff, Lan Xue, Aferdita Bytyqi, Christian Franz, Whitney Gray, Louise Holly, Micaela Neumann, Lipsa Panda, Robert D Smith, Enow Awah Georges Stevens, Brian Li Han Wong
Journal: The Lancet (2021)
Thrombotic Microangiopathy Following COVID-19 Infection
Authors: Mahdis Ghahramanpouri, Amir Abdi Pour, Mita Zahra E. Co, Sayna Norouzi
Journal: Journal of the American Society of Nephrology (2021)

Ghahramanpouri, Mahdis; Pour, Amir Abdi; Co, Mita Zahra E.; Norouzi, Sayna Author Information
Association of Oliguria With Acute Kidney Injury Diagnosis, Severity Assessment, and Mortality Among Patients With Critical Illness
Authors: Nathan Axel Bianchi, Louis Léon Stavart, Marco Altarelli, Tatiana Kelevina, Mohamed Faouzi, Antoine Guillaume Schneider
Journal: JAMA Network Open (2021)

The current definition and staging of acute kidney injury (AKI) considers alterations in serum creatinine (sCr) level and urinary output (UO). However, the relevance of oliguria-based criteria is disputed.To determine the contribution of oliguria, as defined by the Kidney Disease: Improving Global Outcomes (KDIGO) criteria, to AKI diagnosis, severity assessment, and short- and long-term outcomes.This cohort study included adult patients admitted to a multidisciplinary intensive care unit from January 1, 2010, to June 15, 2020. Patients receiving long-term dialysis and those who declined consent were excluded. Daily sCr level and hourly UO measurements along with sociodemographic characteristics and severity scores were extracted from electronic medical records. Long-term mortality was assessed by cross-referencing the database with the Swiss national death registry. The onset and severity of AKI according to the KDIGO classification was determined using UO and sCr criteria separately, and their agreement was assessed.Using a multivariable model accounting for baseline characteristics, severity scores, and sCr stages, the association of UO criteria with 90-day mortality was evaluated. Sensitivity analyses were conducted to assess how missing sCr, body weight, and UO values, as well as different sCr baseline definitions and imputations methods, would affect the main results.Among the 15 620 patients included in the study (10 330 men [66.1%] with a median age of 65 [IQR, 53-75] years, a median Simplified Acute Physiology Score II score of 40.0 [IQR, 30.0-53.0], and a median follow-up of 67.0 [IQR, 34.0-100.0] months), 12 143 (77.7%) fulfilled AKI criteria. Serum creatinine and UO criteria had poor agreement on AKI diagnosis and staging (Cohen weighted κ, 0.36; 95% CI, 0.35-0.37; P < .001). Compared with the isolated use of sCr criteria, consideration of UO criteria enabled identification of AKI in 5630 patients (36.0%). Those patients had a higher 90-day mortality than patients without AKI (724 of 5608 [12.9%] vs 288 of 3462 [8.3%]; P < .001). On multivariable analysis accounting for sCr stage, comorbidities, and illness severity, UO stages 2 and 3 were associated with a higher 90-day mortality (odds ratios, 2.4 [95% CI, 1.6-3.8; P < .001] and 6.2 [95% CI, 3.7-10.5; P < .001], respectively). These results remained significant in all sensitivity analyses.The findings of this cohort study suggest that oliguria lasting more than 12 hours (KDIGO stage 2 or 3) has major AKI diagnostic implications and is associated with outcomes irrespective of sCr elevations.
TCT-8 Prasugrel De-Escalation Therapy After Complex Percutaneous Coronary Intervention in Acute Coronary Syndrome: A Subgroup Analysis of the HOST-REDUCE-POLYTECH-ACS Randomized Clinical Trial
Authors: Doyeon Hwang, Kyung Woo (KW) Park, Kook-Jin Chun, Jung-Kyu Han, Han-Mo Yang, Hyun-Jae Kang, Bon-Kwon Koo, Jeehoon Kang, Yun-Kyeong Cho, Soon Jun Hong, Sang-Hyun Kim, Sang-Ho Jo, Yong Hoon Kim, Weon Kim, Seok-Kyu Oh, Jung-Hee Lee, Hyo-Soo Kim
Journal: Journal of the American College of Cardiology (2021)
Abstract P132: Impact of Location and Social Context on the Probability of a Dietary Lapse Among Adults in Weight Loss Treatment
Authors: Lora E Burke, Saul Shiffman, Dara Mendez, Eileen Chasens, Asim Smailagic, Dan P Siewiorek, Linda J Ewing, Julie Mancino, Stephen Rathbun
Journal: Circulation (2017)

Background: Ecological momentary assessment (EMA) assesses individuals’ current experiences, location and social context in which behaviors occur. During a 12-mo behavioral weight loss intervention and using an EMA app, we asked participants to report any instances of temptations or a lapse from their weight management diet. Objective: Estimate the rate of temptations per unit time and the probability that a lapse will follow based on the location (restaurant, home, work) and the social context ( with others who are eating, completely alone ). Methods: Using a smartphone, participants initiated a report when they experienced a temptation and reported if this led to a lapse. Their location and the social context were recorded during the 5,211 self-reported temptations as well as during 106,960 random assessments over 12 mos. Analyses: A frailty model was used to estimate the rate at which temptations occurred per unit of time and a logistic regression model was used to estimate the probability that a temptation led to a lapse both as a function of location and social context. Results: The sample (N = 150) was predominantly female (90.7%) and White (80.7%), 56.4% were married with 16.4 (2.8) years of education and a mean BMI of 34.0 kg/m 2 (4.6). Temptations occurred most often in a restaurant and the person was with others who were eating or in sight of others who were eating (Fig 1). While temptations occurred infrequently in another person’s home, there was nearly a 65% probability that a lapse would occur there. When with others who are eating , the temptation rate and probability of a lapse were high. Conclusions: Temptations to eat in a manner that is inconsistent with a weight loss plan occur more frequently in certain locations, e.g., restaurants; however, the probability a temptation leads to a lapse is high in a variety of locations and social contexts, e.g., with others who are eating . Interventions need to focus on empowering individuals trying to manage their weight to resist temptations in these at risk locations and social contexts.
Updated Phase 1 Results from MonumenTAL-1: First-in-Human Study of Talquetamab, a G Protein-Coupled Receptor Family C Group 5 Member D x CD3 Bispecific Antibody, in Patients with Relapsed/Refractory Multiple Myeloma
Authors: Amrita Y. Krishnan, Monique C. Minnema, Jesús G. Berdeja, Albert Oriol, Niels W.C.J. van de Donk, Paula Rodriguez-Otero, Elham Askari, Maria-Victoria Mateos, Luciano J. Costa, Raluca I. Verona, Xuewen Ma, Suzette Girgis, Shiyi Yang, Brandi W. Hilder, Jeffery Russell, Jenna D. Goldberg, Ajai Chari
Journal: Blood (2021)
Disparities in attendance of virtual and in-person pediatric dermatology clinics in minority populations: A cross-sectional analysis
Authors: Danny W. Linggonegoro, Abigail Kempf, Casey R. Cai, Damilola M. Shobiye, Phillip D. Hahn, Dionne Graham, Maria Alfieri, Xavier Sanchez Flores, Luis Alvernaz, Brittany Esty, Sophia Delano, Jennifer T. Huang
Journal: Journal of the American Academy of Dermatology (2021)
Abstract 1458: Dyslipidemia and Risk of Atrial Fibrillation: The Niigata Preventive Medicine Study
Authors: Hiroshi Watanabe, Toru Watanabe, Shigeru Sasaki, Yoshifusa Aizawa
Journal: Circulation (2009)

Background: Dyslipidemia is an important risk factor for cardiovascular disease, and an association of dyslipidemia with atrial fibrillation (AF) has also been suggested. However, the results of cr...