tbuckley/cabot-search huggingface dataset:
3D Printed Bone Scaffolds: Delivering Proangiogenic Factors from 3D‐Printed Polycaprolactone Scaffolds for Vascularized Bone Regeneration (Adv. Healthcare Mater. 23/2020)
Authors: Haoming Liu, Yingying Du, Gaojie Yang, Xixi Hu, Lin Wang, Bin Liu, Jianglin Wang, Shengmin Zhang
Journal: Advanced Healthcare Materials (2020)
136P Modified ypTNM staging classification for gastric cancer after neoadjuvant therapy: A multi-institutional study
Authors: W-W. Qiu, Q. Zhong, Z-K. Wang, Q-Y. Chen, C-H. Zheng, P. Li, J-W. Xie, J-B. Wang, J-X. Lin, J. Lu, L-L. Cao, M. Lin, R-H. Tu, Z-N. Huang, J-L. Lin, H-L. Zheng, C. Huang
Journal: Annals of Oncology (2020)
Abstract 14347: A New Risk Model for Prognostic Prediction After Transcatheter Aortic Valve Replacement
Authors: Koichi Maeda, Toru Kuratani, Kyongsun Pak, Kazuo Shimamura, Junpei Yamamoto, Isamu Mizote, Yasuhiro Ichibori, Koichi Toda, Yasushi Sakata, Yoshiki Sawa
Journal: Circulation (2018)

Introduction: Current recommendations for transcatheter aortic valve replacement (TAVR) by the guidelines are that TAVR should be carried out in patients with a life expectancy >1 year. Furthermore...
Sexual Violence in the Media: An Exploration of Traditional Print Media Reporting in the United States, 2014–2017
Authors: Olivia Egen, Laura M. Mercer Kollar, Jenny Dills, Kathleen C. Basile, Bethlehem Besrat, Laura Palumbo, Kellie E. Carlyle
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

Sexual violence is prevalent and, for many victims, begins early in life (1). In the United States, one in five women and one in 38 men report completed or attempted rape victimization during their lifetime, with 43.2% of female and 51.3% of male victims reporting that their first rape victimization occurred before age 18 years (1). Media have been shown to act as a socializing agent for a range of health and social behaviors (2). Media portrayals might influence, reinforce, or modify how the public responds to incidents of sexual violence and their support for prevention efforts and media might construct a lens through which the public can understand who is affected by sexual violence, what forms it takes, why it happens, and who is responsible for addressing it (3). Media portrayals of sexual violence were assessed using a systematic random sample of newspaper articles from 48 of the top 50 distributed traditional print media outlets that were examined for sexual violence content and potential differences by geographic region and year of publication. Differences by year and region in type of sexual violence covered, media language used, and outcomes reported were identified, highlighting an opportunity for public health officials, practitioners, and journalists to frame sexual violence as a preventable public health issue and to incorporate best practices from CDC and the National Sexual Violence Resource Center's Sexual Violence Media Guide (4).
What is the burden of proof for tumor mutational burden in gliomas?
Authors: Mustafa Khasraw, Kyle M Walsh, Amy B Heimberger, David M Ashley
Journal: Neuro-Oncology (2020)

Abstract The treatment of patients with a variety of solid tumors has benefitted from immune checkpoint inhibition targeting the anti-programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) axis. The US Food and Drug Administration (FDA) granted accelerated approval of PD-1 inhibitor, pembrolizumab, for the treatment of adult and pediatric patients with high tumor mutational burden (TMB-H), solid tumors that have progressed following prior treatment, and who have no other treatment options, including the extension to tumors of the central nervous system (CNS). In general, pan-cancer approvals are viewed positively to empower patients and clinicians. There are subsets (eg, BRAF, NTRK) for which this pathway for approval is appropriate. However, the pan-cancer FDA approval of pembrolizumab raises several concerns regarding the generalizability of the evidence to other tumor types, including managing patients with gliomas and other CNS tumors. The cutoff for TMB-H is not well defined. There are intrinsic immunological differences between gliomas and other cancers types, including the immunosuppressive glioma microenvironment, the tumor’s effects on systemic immune function, and the transformation of the T-cell populations to an exhausted phenotype in glioma. Here, we address the caveats with pan-cancer approvals concerning gliomas and complexities of the unique CNS immune environment, discuss potential predictive biomarkers, including TMB, and explain why the recent approval should be applied with caution in CNS tumors.
Possible Reverse Causation and Confounding in Study of the Association of Sedentary Behavior With Cancer Mortality—Reply
Authors: Keith M. Diaz, Susan C. Gilchrist
Journal: JAMA Oncology (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Environmental factors and periodontal microbiome
Authors: Nurcan Buduneli
Journal: Periodontology 2000 (2020)

Abstract Periodontal diseases are chronic inflammatory, multifactorial diseases where the major triggering factors for disease onset are bacteria and their toxins, but the major part of tissue destruction occurs as a result of host response towards the periodontal microbiome. Periodontal microbiome consists of a wide range of microorganisms including obligate and facultative anaerobes. In health, there is a dynamic balance between the host, environment, and the microbiome. Environmental factors, mainly tobacco smoking and psychological stress, disrupt the symbiotic relationship. Tobacco smoke and its components alter the bacterial surface and functions such as growth. Psychological stressors and stress hormones may affect the outcome of an infection by changing the virulence factors and/or host response. This review aims to provide currently available data on the effects of the major environmental factors on the periodontal microbiome.
Phase I and Pharmacologic Study of Olaparib in Combination with High-dose Radiotherapy with and without Concurrent Cisplatin for Non–Small Cell Lung Cancer
Authors: Rosemarie de Haan, Michel M. van den Heuvel, Judi van Diessen, Heike M.U. Peulen, Erik van Werkhoven, Adrianus J. de Langen, Ferry Lalezari, Dick Pluim, Manon Verwijs-Janssen, Conchita Vens, Jan H.M. Schellens, Neeltje Steeghs, Marcel Verheij, Baukelien van Triest
Journal: Clinical Cancer Research (2020)

To identify an MTD of olaparib, a PARP inhibitor, in combination with loco-regional radiotherapy with/without cisplatin for the treatment of non-small cell lung cancer (NSCLC).Olaparib dose was escalated in two groups: radiotherapy (66 Gy/24 fractions in 2.75 Gy/fraction) with and without daily cisplatin (6 mg/m2), using time-to-event continual reassessment method with a 1-year dose-limiting toxicity (DLT) period. The highest dose level with a DLT probability <15% was defined as MTD. Poly ADP-ribose (PAR) inhibition and radiation-induced PAR-ribosylation (PARylation) were determined in peripheral blood mononuclear cells.Twenty-eight patients with loco-regional or oligometastatic disease (39%) were treated: 11 at olaparib 25 mg twice daily and 17 at 25 mg once daily. The lowest dose level with cisplatin was above the MTD due to hematologic and late esophageal DLT. The MTD without cisplatin was olaparib 25 mg once daily. At a latency of 1-2.8 years, severe pulmonary adverse events (AE) were observed in 5 patients across all dose levels, resulting in 18% grade 5 pulmonary AEs. Exploratory analyses indicate an association with the radiation dose to the lungs. At the MTD, olaparib reduced PAR levels by more than 95% and abolished radiation-induced PARylation. Median follow-up of survivors was 4.1 years. Two-year loco-regional control was 84%, median overall survival in patients with locally advanced NSCLC was 28 months.Combined mildly hypofractionated radiotherapy and low-dose daily cisplatin and olaparib was not tolerable due to esophageal and hematologic toxicity. Severe pulmonary toxicity was observed as well, even without cisplatin. More conformal radiotherapy schedules with improved pulmonary and esophageal sparing should be explored.
The role of gut vascular barrier in experimental alcoholic liver disease and A. muciniphila supplementation
Authors: Christoph Grander, Felix Grabherr, Ilaria Spadoni, Barbara Enrich, Georg Oberhuber, Maria Rescigno, Herbert Tilg
Journal: Gut Microbes (2020)

The translocation of bacterial components from the intestinal lumen into the portal circulation is crucial in the pathogenesis of alcoholic liver disease (ALD). Recently the important role of the gut vascular barrier (GVB) was elucidated in alcoholic liver disease. Here we report about the influence of A. muciniphila supplementation in experimental ALD on the GVB. Ethanol feeding was associated with increased Pv-1, indicating altered endothelial barrier function, whereas A. muciniphila administration tended to restore GVB. To further investigate GVB in experimental ALD, β-catenin gain-of-function mice, which display an enhanced GVB, were ethanol-fed. β-catenin gain-of-function mice were not protected from ethanol-induced liver injury, suggest an alternative mechanism of ethanol-induced GVB disruption. The description of the GVB in ALD could pave the way for new therapeutic options in the future.
Cell relay-delivery improves targeting and therapeutic efficacy in tumors
Authors: Ye Feng, Qianqian Liu, Yi Li, Yang Han, Meng Liang, Hao Wang, Qing Yao, Yuli Wang, Meiyan Yang, Zhiping Li, Wei Gong, Yang Yang, Chunsheng Gao
Journal: Bioactive Materials (2020)

Cell-mediated drug delivery system (CDDS) has shown great potential for cancer therapy. However, a single cell-mediated drug delivery mechanism has not generally been successful, particularly for systemic administration. To augment the antitumor therapy efficacy, herein, we propose a strategy of cell relay-delivery for the use of artificially damaging/aging erythrocytes to hitchhike on circulating monocytes/macrophages for intratumoral accumulation of anticancer drugs. This biomimetic relay-delivery strategy was derived from the manner in which circulating monocytes/macrophages in body specifically engulf damaged/senescent erythrocytes and actively transmigrate into the tumor bulk. The strategy elegantly combines the natural functions of both cells, which therefore provides a new perspective to challenge current obstacles in drug delivery. According to the strategy, we developed biotinylated erythrocyte-poly (lactic-co-glycolic acid) (PLGA) nanoparticle hybrid DDSs (bE-NPs) using avidin-biotin coupling. In such a system, biotinylated erythrocytes can mimic the natural property of damaged/senescent erythrocytes, while PLGA NPs are capable of encapsulating anticancer drugs and promoting sustained drug release. Anticancer drugs can effectively target tumor sites by two steps. First, by using biotinylated erythrocytes as the carrier, the drug-loaded PLGA NPs could be specifically phagocytized by monocytes/macrophages. Second, by taking advantage of the tumor-tropic property of monocytes/macrophages, the drug-loaded PLGA NPs could be efficiently transported into the tumor bulk. After encapsulating vincristine (VIN) as the model drug, bE-NPs exhibited the most favorable antitumor effects in vitro and in vivo by the cell relay-delivery effect. These results demonstrate that the cell relay-delivery provides a potential method for improving tumor treatment efficacy.
A Cool Heart Protected From Infarction: Clinical Translation of Breathing Chilled Liquids⁎⁎Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Authors: Wilbur Y.W. Lew
Journal: Journal of the American College of Cardiology (2007)
15788 The standardized extract of Centella asiatica, ECa 233, enhances post-laser resurfacing wound healing on the face: A split-face, double-blind, randomized, placebo-controlled trial
Authors: Wilawan Damkerngsuntorn, Pawinee Rerknimitr, Pravit Asawanonda, Ratchathorn Panchaprateep, Chanat Kumtornrut, Stephen Kerr, Natsinee Tangkijngamvong, Phisit Khemawoot
Journal: Journal of the American Academy of Dermatology (2020)
Impact of the COVID-19 pandemic on the diagnosis, management and prognosis of infective endocarditis
Authors: Laura Escolà-Vergé, Guillermo Cuervo, Arístides de Alarcón, Dolores Sousa, Laura Varela Barca, Nuria Fernández-Hidalgo, Arístides de Alarcón, Encarnación Gutiérrez-Carretero, Rafael Luque-Márquez, Blanca Anaya Baz, Luis Eduardo López-Cortés, Zaira Palacios Baena, María Victoria García López, Guillermo Ojeda Burgos, Antonio Pláta Ciézar, José María Reguera Iglesias, Ricardo Vivancos Delgado, Carmen Hidalgo-Tenorio, Sergio Sequera, None Ch, María Carmen Fariñas, Claudia González-Rico, José Francisco Gutiérrez-Díez, Gonzalo Cabezón, Javier López, Alberto San Román, Benito Almirante, Laura Escolà-Vergé, Rubén Fernández, Nuria Fernández-Hidalgo, Maria Teresa Gonzàlez-Alujas, Olga Maisterra, Gerard Oristrell, María Nazarena Pizzi, Pau Rello, Remedios Ríos, Albert Roque, Antonia Sambola, Toni Soriano, Guillermo Cuervo, Immaculada Grau, Sara Grillo, Lourdes Mateu Pruñonosa, Maria Lluïsa Pedro-Botet Montoya, Nuria Vallejo Camazón, Marta Hernández-Meneses, Jose M. Miro, Eduard Quintana, Antonio José Barros, Mercè Gurgui, Alba Rivera, María Laura Castelo Corral, Efrén Sánchez Vidal, Dolores Sousa, María Teresa Pérez-Rodríguez, Adrián Sousa, Milagros Suárez, Maria Àngels Ribas Fernández, Laura Varela Barca, Laura Vidal Bonet, Lara García-Álvarez, José A. Oteo, Adrián Jerónimo Baza, Carmen Olmos, Isidre Vilacosta, Laura Domínguez-Pérez, Francisco López-Medrano, Javier T. Solera Rallo, José Luis Moya Mur, Enrique Navas Elorza, Andrea Kallmeyer Mayor, Ana María Pello, Luis Nieto Roca, María Aguilera García, Carmen de las Cuevas Torres, Carmen Sáez Béjar, Daniel de Castro Campos, Fernando Domínguez, Antonio Ramos-Martínez, Patricia Muñoz García, María Olmedo Samperio, Maricela Valerio Minero, Elisa García Vázquez, Alicia Hernández Torres, Encarnación Moral Escudero, Miguel Ángel Goenaga Sánchez, Xavier Kortajarena Urkola, Karlos Reviejo Jaka, Elena Bereciartua, Josune Goikoetxea, Regino Rodríguez, Martín Reyes Acevedo
Journal: Clinical Microbiology and Infection (2020)
15117 Quality of life impact in adolescent patients with moderate to severe atopic dermatitis: Screening data from the LIBERTY AD ADOL trial
Authors: Marjolein de Bruin-Weller, Mette Deleuran, Eric L. Simpson, Laurent Eckert, Ashish Bansal, Zhen Chen, Randy Prescilla, Susan H. Boklage, Paola Mina-Osorio
Journal: Journal of the American Academy of Dermatology (2020)
Polyphosphazenes enable durable, hemocompatible, highly efficient antibacterial coatings
Authors: Victoria Albright, Daniel Penarete-Acosta, Mary Stack, Jeremy Zheng, Alexander Marin, Hanna Hlushko, Hongjun Wang, Arul Jayaraman, Alexander K. Andrianov, Svetlana A. Sukhishvili
Journal: Biomaterials (2020)
137P Clinical utility of circulating tumour DNA (ctDNA) in resectable gastric cancer (GC)
Authors: M. Fedyanin, E. Ignatova, U. Boyarskikh, E. Polyanskaya, A. Kechin, I. Osccorobin, D. Shamovskaya, A. Popova, A. Trigolosov, M. Nikulin, S. Nered, A. Kalinin, I. Stilidi, E. Moroz, M. Filipenko, S. Tjulandin
Journal: Annals of Oncology (2020)
174P A real-world study of PD-1 inhibitors combined with TKIs for HCC with major vascular invasion as the conversion therapy: A prospective, non-randomized, open-label cohort study
Authors: W. Zhang, B. Hu, J. Han, H. Wang, Z. Wang, H. Ye, G. Ma, M. Chen, S. Cai, X. Wang, J. Cao, Y. Cheng, S. Lu
Journal: Annals of Oncology (2020)
391P Economic impact of next-generation sequencing (NGS) versus single-gene testing modalities to detect genomic alterations (GAs) in metastatic non-small cell lung cancer (mNSCLC) in Asia
Authors: H. Loong, C.K.H. Wong, L.K.S. Leung, C.P.K. Chan, A. Chang, Z-Y. Zhou, W. Tang, M. Gibbs
Journal: Annals of Oncology (2020)
Gerotechnology for Older Adults With Cardiovascular Diseases
Authors: Ashok Krishnaswami, Craig Beavers, Michael P. Dorsch, John A. Dodson, Ruth Masterson Creber, Spyros Kitsiou, Parag Goyal, Mathew S. Maurer, Nanette K. Wenger, Deborah S. Croy, Karen P. Alexander, John A. Batsis, Mintu P. Turakhia, Daniel E. Forman, Gwen M. Bernacki, James N. Kirkpatrick, Nicole M. Orr, Eric D. Peterson, Michael W. Rich, Andrew M. Freeman, Sanjeev P. Bhavnani
Journal: Journal of the American College of Cardiology (2020)
Current Status of and Perspectives on the Application of Marmosets in Neurobiology
Authors: Hideyuki Okano
Journal: Annual Review of Neuroscience (2020)

The common marmoset ( Callithrix jacchus), a small New World primate, is receiving substantial attention in the neuroscience and biomedical science fields because its anatomical features, functional and behavioral characteristics, and reproductive features and its amenability to available genetic modification technologies make it an attractive experimental subject. In this review, I outline the progress of marmoset neuroscience research and summarize both the current status (opportunities and limitations) of and the future perspectives on the application of marmosets in neuroscience and disease modeling.
A Randomized Phase IIb Study of Low-dose Tamoxifen in Chest-irradiated Cancer Survivors at Risk for Breast Cancer
Authors: Smita Bhatia, Melanie R. Palomares, Lindsey Hageman, Yanjun Chen, Wendy Landier, Kandice Smith, Heidi Umphrey, Caroline A. Reich, Kathryn W. Zamora, Saro H. Armenian, Therese B. Bevers, Anne Blaes, Tara Henderson, David Hodgson, Melissa M. Hudson, Larissa A. Korde, Susan A. Melin, Sofia D. Merajver, Linda Overholser, Sandhya Pruthi, F. Lennie Wong, Judy E. Garber
Journal: Clinical Cancer Research (2020)

Low-dose tamoxifen reduces breast cancer risk, but remains untested in chest-irradiated cancer survivors-a population with breast cancer risk comparable with BRCA mutation carriers. We hypothesized that low-dose tamoxifen would be safe and efficacious in reducing radiation-related breast cancer risk.We conducted an investigator-initiated, randomized, phase IIb, double-blinded, placebo-controlled trial (FDA IND107367) between 2010 and 2016 at 15 U.S. sites. Eligibility included ≥12 Gy of chest radiation by age 40 years and age at enrollment ≥25 years. Patients were randomized 1:1 to low-dose tamoxifen (5 mg/day) or identical placebo tablets for 2 years. The primary endpoint was mammographic dense area at baseline, 1 and 2 years. IGF-1 plays a role in breast carcinogenesis; circulating IGF-1 and IGF-BP3 levels at baseline, 1 and 2 years served as secondary endpoints.Seventy-two participants (low-dose tamoxifen: n = 34, placebo: n = 38) enrolled at a median age of 43.8 years (35-49) were evaluable. They had received chest radiation at a median dose of 30.3 Gy. Compared with the placebo arm, the low-dose tamoxifen arm participants had significantly lower mammographic dense area (P = 0.02) and IGF1 levels (P < 0.0001), and higher IGFBP-3 levels (P = 0.02). There was no difference in toxicity biomarkers (serum bone-specific alkaline phosphatase, lipids, and antithrombin III; urine N-telopeptide cross-links) between the treatment arms. We did not identify any grade 3-4 adverse events related to low-dose tamoxifen.In this randomized trial in chest-irradiated cancer survivors, we find that low-dose tamoxifen is effective in reducing established biomarkers of breast cancer risk and could serve as a risk-reduction strategy.
Abstract IA18: Clock Control of HIF Activity and Muscle Tissue Regeneration
Authors: Clara Bien Peek
Journal: Cancer Research (2020)

Abstract Circadian clocks generate rhythmic pulses of glucose metabolism and respiration to divide energy-producing and energy-consuming processes into separate periods in the light-dark cycle. At the cellular level, clocks direct the expression of thousands of genes involved in metabolism, tissue growth, and repair, yet our understanding of how clocks detect signals in the environment to coordinate transcription and metabolic flux at precise stages during development and in post-mitotic cells remains poorly understood. A breakthrough in understanding circadian mechanisms in metabolic plasticity came from our discovery that molecular clock transcription factors respond to changes in environmental oxygen. We uncovered a link between circadian clocks and the control of the oxygen- and mitochondrial stress-responsive hypoxia-inducible factor (HIF) pathway, which controls adaptation to low oxygen environments, such as during tumorigenesis and ischemic injury. Here, we demonstrate a role for the circadian clock in post-muscle injury myogenesis and tissue regeneration. Indeed, loss of Bmal1 in adult muscle stem cell populations leads to impaired regeneration after ischemic muscle injury in mice. Furthermore, we observe time-of-day differences in muscle regeneration rates, with more rapid tissue repair following injury during the dark (active) phase. In addition, myogenesis is reduced in primary Bmal1-/- myoblasts compared to controls, a phenotype that is exaggerated in hypoxic conditions. Finally, we observe that loss of Bmal1 in myoblasts leads to chromatin remodeling that alters transcription of genes involved in metabolic flux and myogenic gene expression. Together, our studies demonstrate that circadian clocks in muscle stem cells control metabolic and genomic reprogramming under hypoxia to regulate in vitro myogenesis and in vivo skeletal muscle regeneration. Citation Format: Clara Bien Peek. Clock Control of HIF Activity and Muscle Tissue Regeneration [abstract]. In: Abstracts: AACR Special Virtual Conference on Epigenetics and Metabolism; October 15-16, 2020; 2020 Oct 15-16. Philadelphia (PA): AACR; Cancer Res 2020;80(23 Suppl):Abstract nr IA18.
Diagnosing the Mechanism of Supraventricular Tachycardia: Restoring the Luster of a Fading Art⁎⁎Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Authors: Francis E. Marchlinski
Journal: Journal of the American College of Cardiology (2009)
Abstract 1437: Target Deletion of Class A Macrophage Scavenger Receptor Contributes to Susceptibility of Cardiac Rupture After Experimental Myocardial Infarction in Mice
Authors: Kenichi Tsujita, Koichi Kaikita, Takanori Hayasaki, Naomi Sakashita, Motohiro Takeya, Hisao Ogawa
Journal: Circulation (2006)

Background Cardiac rupture remains a serious complication of acute myocardial infarction (MI), and has been shown to be caused by disruption of extracellular matrix (ECM) structures, which is trigg...
13861 Human tissue engineered skin substitutes based on hyaluronic acid for wound healing: Epidermal barrier study
Authors: Álvaro Sierra-Sánchez, Antonio Lizana Moreno, Ana Fernández-González, Olga Espinosa-Ibáñez, Antonio Martinez-Lopez, Jorge Guerrero Calvo, Natividad Fernández-Porcel, Antonio Ruiz-Garcia, Alexandra Ordóñez-Luque, Salvador Arias-Santiago
Journal: Journal of the American Academy of Dermatology (2020)