tbuckley/cabot-search huggingface dataset:
Table of Contents
Authors: Tejas Desai, Arvind Conjeevaram, Omar Taco, Sanjeev Nair, Sivakumar Sridharan, Rolando Claure-Del, Brendon Granado, Raju Krishnam, Gopal Penmatsa, Florian Basu, Ernesto Buchkremer, Fernanda Lopez-Almaraz, Xavier Amare, Miguel Parada, Zoran Vargas, Francesco Paunic, Amit Iannuzzella, Hector Langote, Sonia Madariaga, Sibel Rodriguez Ramirez, Carlos Gokcay Bek, Ananda Orantes, Garima Chapagain, Mayuri Aggarwal, Sidharth Trivedi, Deirdre Sawinski, Christina Wyatt, Jayme Locke, Naoto Hamano, Hirotaka Komaba, Masafumi Fukagawa, Wendy Lea, Christopher Ward, Carlo Basile, Carlo Lomonte, Kerstin Amann, Daniel Galvan, Nathanael Green, Farhad Danesh
Journal: Kidney International (2017)
TCT-796 Impact of Nitinol Self-Expanding Stent on the Patency of SubIntimal Angioplasty for Below-The-Knee Occlusions with Critical Limb Ischemia (NEXSIA-BTK): Multicenter, prospective registry
Authors: Jung-Hee Lee, Jaewon Oh, Young-Guk Ko, Seung-Woon Rha, Ki Chang Kim, Sang-Ho Park, Donghoon Choi
Journal: Journal of the American College of Cardiology (2015)
The RSPO‐LGR4/5‐ZNRF3/RNF43 module in liver homeostasis, regeneration, and disease
Authors: Stefano Annunziato, Tianliang Sun, Jan S. Tchorz
Journal: Hepatology (2022)

Abstract WNT/β‐catenin signaling plays pivotal roles during liver development, homeostasis, and regeneration. Likewise, its deregulation disturbs metabolic liver zonation and is responsible for the development of a large number of hepatic tumors. Liver fibrosis, which has become a major health burden for society and a hallmark of NASH, can also be promoted by WNT/β‐catenin signaling. Upstream regulatory mechanisms controlling hepatic WNT/β‐catenin activity may constitute targets for the development of novel therapies addressing these life‐threatening conditions. The R‐spondin (RSPO)–leucine‐rich repeat‐containing G protein‐coupled receptor (LGR) 4/5–zinc and ring finger (ZNRF) 3/ring finger 43 (RNF43) module is fine‐tuning WNT/β‐catenin signaling in several tissues and is essential for hepatic WNT/β‐catenin activity. In this review article, we recapitulate the role of the RSPO‐LGR4/5‐ZNRF3/RNF43 module during liver development, homeostasis, metabolic zonation, regeneration, and disease. We further discuss the controversy around LGR5 as a liver stem cell marker.
Pitfalls in predicting nonfatal outcomes of percutaneous coronary interventions: Lessons from large regional angioplasty registries David J. Malenka, Mauro Moscucci, David E. Wennberg, Hebe B. Quinton, Winthrop D. Piper, Mirle A. Kellet, Andrea Sievers, F. Lee Lucas, Paul D. McGrath, Gerald T. O'Connor. Northern New England Cardivascular Study Group, Lebanon, NH, BC/BS of Michigan Cardiovascular Consortium, Ann Arbor, MI
Journal: Journal of the American College of Cardiology (2001)
Active targeted Janus nanoparticles enable anti-angiogenic drug combining chemotherapy agent to prevent postoperative hepatocellular carcinoma recurrence
Authors: Xiu-Ping Zhang, Xiang-Jun Chen, Bo-Zhao Li, Shuai Xu, Zhou-Liang Wu, Ming-Gen Hu, Zhi-Ming Zhao, Guo-Dong Zhao, Chang-Rong Wang, Wei Hong, Su-Ping Li, Lu Li, Chun-Gang Wang, Guangjun Nie, Rong Liu
Journal: Biomaterials (2022)
Early experience of combining immune checkpoint inhibitor and radiotherapy in heavily pretreated hepatobiliary cancer.
Authors: Yong Tae Kim, Byung Min Lee, Jinsil Seong
Journal: Journal of Clinical Oncology (2022)

457 Background: Promising therapeutic results of immune checkpoint inhibitor (ICI) have been reported in various solid tumors. Radiotherapy (RT) is known to enhance the immunogenic effect. The immunogenic effect of RT is expected to improve the therapeutic effect of ICI. In this study, we aimed to investigate the efficacy and toxicity of combining ICI and RT in hepatobiliary cancer. Methods: Patients who received RT and ICI combination therapy for hepatobiliary cancer from January 2020 to April 2021 were retrospectively reviewed. Baseline patient characteristics such as age at diagnosis, stage, previous treatment, radiation dose, tumor volume, and lymphocyte count were recorded. The primary endpoints were in-field and out-field control rate. The secondary endpoint was treatment-related toxicities. Overall survival and progression-free survival were also evaluated. The disease control rate and survival were assessed using the Kaplan-Meier method. Results: In total, 17 patients and 35 treated lesions were included for analysis. The median follow up period was 5.5 months (range 2.4 – 19.8 months). Of the 17 patients, 14 were diagnosed hepatocellular carcinoma (82.4%). Twelve patients had distant metastasis (70.6%). Various treatments were administered to the patients prior to ICI and RT combination treatment. The 6-month overall survival and progression-free survival was 62.7% and 26.5%, respectively. The 6-month in-field control rate was 67.4% and 6-month out-field control rate was 26.6%. Higher BED (≥ 90 Gy) was a significant prognostic factor for both in-field and out-field control, and lymphopenia (≤ 800 /μL) at the time of RT start was a poor prognostic factor for outfield control. Fractional dose of less than 5 Gy showed improved in-field and out-field control. Treatment related toxicity occurred in 10 patients (58.8%). The most frequent adverse event was GI disorders such as esophagitis (n = 3) and epigastric pain (n = 3). Patients who experienced treatment-related toxicity were well recovered after conservative care. There was no grade 3 or 4 toxicity. Conclusions: The combination of ICI and RT showed substantial efficacy with acceptable toxicity in heavily pretreated advanced hepatobiliary cancer patients. Dose per fraction of less than 5 Gy may be appropriate for better efficacy in future study of combining ICI and RT. The results of this study provides a basis for future prospective study in hepatobiliary cancer.
Association News
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tissue‐Like Optoelectronic Neural Interface Enabled by PEDOT:PSS Hydrogel for Cardiac and Neural Stimulation
Authors: Mertcan Han, Erdost Yildiz, Hümeyra Nur Kaleli, Selcan Karaz, Guncem Ozgun Eren, Itir Bakis Dogru‐Yuksel, Erkan Senses, Afsun Şahin, Sedat Nizamoglu
Journal: Advanced Healthcare Materials (2021)

Abstract Optoelectronic biointerfaces have made a significant impact on modern science and technology from understanding the mechanisms of the neurotransmission to the recovery of the vision for blinds. They are based on the cell interfaces made of organic or inorganic materials such as silicon, graphene, oxides, quantum dots, and π ‐conjugated polymers, which are dry and stiff unlike a cell/tissue environment. On the other side, wet and soft hydrogels have recently been started to attract significant attention for bioelectronics because of its high‐level tissue‐matching biomechanics and biocompatibility. However, it is challenging to obtain optimal opto‐bioelectronic devices by using hydrogels requiring device, heterojunction, and hydrogel engineering. Here, an optoelectronic biointerface integrated with a poly(3,4‐ethylenedioxythiophene):poly(styrene sulfonate), PEDOT:PSS, hydrogel that simultaneously achieves efficient, flexible, stable, biocompatible, and safe photostimulation of cells is demonstrated. Besides their interfacial tissue‐like biomechanics, ≈34 kPa, and high‐level biocompatibility, hydrogel‐integration facilitates increase in charge injection amounts sevenfolds with an improved responsivity of 156 mA W −1 , stability under mechanical bending , and functional lifetime over three years. Finally, these devices enable stimulation of individual hippocampal neurons and photocontrol of beating frequency of cardiac myocytes via safe charge‐balanced capacitive currents. Therefore, hydrogel‐enabled optoelectronic biointerfaces hold great promise for next‐generation wireless neural and cardiac implants.
Survey of challenges in access to diagnostics and treatment for neuroendocrine tumor patients (SCAN): The diagnostic process of GEP-NETs in Australia, Canada, China, France, Germany, the United Kingdom, and the United States of America.
Authors: Mark McDonnell, Catherine Bouvier, Marianne E. Pavel, Harjit Singh, James R. Howe, Simron Singh, Jie Chen, Dirk Van Genechten, Elyse Gellerman, Sugandha Dureja, Simone Leyden, Christine Rodien-Louw, Teodora Kolarova, Dermot O'Toole
Journal: Journal of Clinical Oncology (2022)

502 Background: SCAN assessed the global delivery of NET diagnostics and treatment. This analysis focused on the diagnostic process in gastroenteropancreatic (GEP) neuroendocrine tumor (NET) patients in countries with more robust respondent samples (at least 100 units of analysis): Australia (AU), Canada (CA), China (CH), France (FR), Germany (DE), United Kingdom (UK), and the United States (USA). Methods: During Sept-Nov 2019, 2359 NET patients &amp; caregivers, and 436 healthcare professionals (HCPs) completed a self-reported online survey, available in 14 languages, disseminated via INCA and its partner networks. Results: 71% (1670/2359) were GEP-NET patients, 71% of which were from 7 countries (1188/1670), namely AU (7%, 120/1670), CA (9%, 154/1670), CH (7%, 114/1670), FR (8%, 137/1670), DE (9%, 149/1670), UK (11%, 191/1670) and USA (19%, 323/1670). Primary GEP-NETs were predominantly small intestinal (SI) with similar proportions in AU, CA, DE, FR,, UK and US and smaller in CH (*p &lt; 0.001, Chi-squared). Second most common primary was pancreatic NET (similar across countries). Misdiagnosis was very frequent and occurred at least once but most commonly multiple times (table). The most frequent misdiagnoses were irritable bowel syndrome (AU 60%, CA 34%, CH 14%, FR 27%, DE 31%, UK 55%, USA 55%) and gastritis (AU 42%, CA 37%, CH 51%, FR 51%, DE 37%, UK 30%, USA 51%). Patients presented with stage IV disease in more than half of cases in 5 countries (table). On average three HCPs were involved in the diagnostic process in all above-mentioned countries. The HCPs who most often suggested the test that led to the correct diagnosis were gastroenterologists in CH 28%, FR 43%, DE 34%, USA 28%, and GPs in AU 28%, CA 27%, and UK 24% (45/191). In the majority of cases the diagnosis was received in a hospital without a NET specialist, except for CH (AU 38%; CA 42%; CH 25%; FR 36%, DE 51%, UK 44%, USA 45%). Conclusions: SCAN demonstrates some interesting geographical variations with respect to tumor demographics and stage at presentation. Nonetheless, delayed GEP-NET diagnosis remains a significant global challenge. Enhanced knowledge about GEP-NETs in hospitals without NET specialists, especially among gastroenterologists and family doctors (GPs), will drive improvements in global NET care.[Table: see text]
One in five doctors feels overwhelmed daily by covid and winter pressures, RCP reports
Authors: Gareth Iacobucci
Journal: BMJ (2022)

One in five doctors feels overwhelmed daily by covid and winter pressures, RCP reports Gareth IacobucciOver two thirds of doctors (69%) have felt overwhelmed at work at least once in the past three weeks as rising covid cases and winter illnesses heap pressure on healthcare services, a survey by the Royal College of Physicians (RCP) has found. 1 Of 1218 doctors who responded to the poll, a fifth (20.5%) said that they had felt overwhelmed almost every day during those three weeks.Some 21.5% had done so once or twice a week, and 27.5% had felt overwhelmed once or twice.The survey was conducted from 8 to 11 January 2022.The college said that the results were probably due to high levels of staff absence which, although slightly improved since last month, were still putting "immense pressure" on exhausted and demoralised staff working under "extreme pressure.
Trump versus Biden: a fight for the health of a nation
Authors: None The Lancet
Journal: The Lancet (2020)

With only 73 days until Nov 3, the 2020 presidential election in the US has entered a decisive phase with Democratic candidate Joe Biden's announcement of California Senator Kamala Harris as his running mate. It comes against the backdrop of the COVID-19 pandemic that has revealed a nation of stark inequity, especially in terms of health. Over the past three decades, non-communicable diseases, especially cardiovascular diseases, cancers, neurological disorders, chronic respiratory diseases, diabetes, and chronic kidney disease have been the predominant causes of death and disability in the US.
Notices
Authors: Roberto Groszmann, J Henderson, Daniel Longnecker, John Williams, Sarah Kalser
Journal: Hepatology (1991)

This symposium is sponsored by the Istituto di Ricerche di Biologia Molecolare and will feature a multinational panel of speakers.The topics to be addressed include chromatin, genetically defined loci, transcriptional regulation, posttranscriptional regulation, liver and diseases, cell biology of the liver and hormones and cytokines.
Uninsured children and national health reform
Authors: M. S. Marquis
Journal: JAMA (1992)

THE HEALTH of the nation's children and their access to care has received renewed public policy attention in recent years. A special policy focus on children derives in part from evidence of the cost-effectiveness of preventive and primary care for children.<sup>1</sup>However, lack of health insurance poses a significant financial barrier to the receipt of the recommended levels of preventive care, especially for poor children. An increase in the share of the cost of health care the family has to pay out-of-pocket is associated with a decrease in immunizations for all children less than age 7 years and a decrease in the likelihood of having a general medical examination and a vision examination among poor children.<sup>2,3</sup>Increased patient cost-sharing also deters poor families from seeking ambulatory care for children for acute problems for which medical advice is highly effective, such as otitis media, "strep throat," lacerations, and fractures.<sup>3</sup>
The Lived Experience of Nurses Working in Cardiology Services with Online Continuing Professional Programs in Advancing their Specialized Clinical Practice: Phenomenology Study Analysis
Authors: Issa Salmi
Journal: Clinical Cardiology and Cardiovascular Interventions (2021)

Introduction: Cardiology nursing is one of the most challenging nursing specialties. Online continuing professional development (CPD) programs may allow nurses to fulfil the demand for specialty competency. Methods and materials: This manuscript described the process of data analysis and discusses the philosophical and theoretical frameworks that shape this study. the study was conducted in one of the largest accredited teaching hospitals in South Australia. Results: Volunteer participants were interviewed where each participant was given a pseudonym to protect confidentiality. First, interviews were transcribed manually. Transcription is considered an interpretive act and a perfect way to immerse oneself within the data because it helps create initial meanings. Second, the researcher listened to each interview while checking compatibility with the transcript. Third, the researcher read and re-read transcripts and highlighted essential ideas before the coding process. Repeated transcript reading helped develop main ideas, recognise shared thoughts, meanings, and patterns, and identify potential themes. Furthermore, it was evident during this stage that some of the researcher’s pre-assumptions regarding the phenomena were revealed in certain aspects of nurses’ lived experiences. In addition, audio recordings and a reflective diary were utilised to reveal non-verbal clues of participants, adding depth and transparency to data analysis. The final step involved writing a summary for each transcript containing the main ideas. Conclusions: It is apparent that six main themes were embedded in the lived experiences of the RNs working in cardiac services and using the online CPD course to advance themselves knowledge and skills.
Gut, London
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Marriages.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Utilization of the emergency medical system among patients with myocardial infarction in the reperfusion era: Results from the NRMI 2 John G. Canto, Rob Zalenski, Joseph P. Ornato, William J. Rogers, Catarina I. Kiefe, David Magid, Michael Shlipak, Paul Frederick, Costas G. Lambrew, Hal V. Barron. university of Alabama at Birmingham, Birmingham, AL
Journal: Journal of the American College of Cardiology (2001)
Chemotherapy-induced infiltration of neutrophils promotes pancreatic cancer metastasis via Gas6/AXL signalling axis
Authors: Gaia Bellomo, Carolyn Rainer, Valeria Quaranta, Yuliana Astuti, Meirion Raymant, Elzbieta Boyd, Ruth Stafferton, Fiona Campbell, Paula Ghaneh, Christopher M Halloran, Dean E Hammond, Jennifer P Morton, Daniel Palmer, Dale Vimalachandran, Robert Jones, Ainhoa Mielgo, Michael C Schmid
Journal: Gut (2022)

Objective Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease and cytotoxic chemotherapy is the standard of care treatment for patients with advanced disease. Here, we investigate how the microenvironment in PDAC liver metastases reacts to chemotherapy and its role in metastatic disease progression post-treatment, an area which is poorly understood. Design The impact of chemotherapy on metastatic disease progression and immune cell infiltrates was characterised using flow and mass cytometry combined with transcriptional and histopathological analysis in experimental PDAC liver metastases mouse models. Findings were validated in patient derived liver metastases and in an autochthonous PDAC mouse model. Human and murine primary cell cocultures and ex vivo patient-derived liver explants were deployed to gain mechanistical insights on whether and how chemotherapy affects the metastatic tumour microenvironment. Results We show that in vivo, chemotherapy induces an initial infiltration of proinflammatory macrophages into the liver and activates cytotoxic T cells, leading only to a temporary restraining of metastatic disease progression. However, after stopping treatment, neutrophils are recruited to the metastatic liver via CXCL1 and 2 secretion by metastatic tumour cells. These neutrophils express growth arrest specific 6 (Gas6) which leads to AXL receptor activation on tumour cells enabling their regrowth. Disruption of neutrophil infiltration or inhibition of the Gas6/AXL signalling axis in combination with chemotherapy inhibits metastatic growth. Chemotherapy increases Gas6 expression in circulating neutrophils from patients with metastatic pancreatic cancer and recombinant Gas6 is sufficient to promote tumour cell proliferation ex vivo, in patient-derived metastatic liver explants. Conclusion Combining chemotherapy with Gas6/AXL or neutrophil targeted therapy could provide a therapeutic benefit for patients with metastatic pancreatic cancer.
Correction: The World Health Organization Fetal Growth Charts: A Multinational Longitudinal Study of Ultrasound Biometric Measurements and Estimated Fetal Weight
Authors: Torvid Kiserud, Gilda Piaggio, Guillermo Carroli, Mariana Widmer, José Carvalho, Lisa Neerup Jensen, Daniel Giordano, José Guilherme Cecatti, Hany Abdel Aleem, Sameera A. Talegawkar, Alexandra Benachi, Anke Diemert, Antoinette Tshefu Kitoto, Jadsada Thinkhamrop, Pisake Lumbiganon, Ann Tabor, Alka Kriplani, Rogelio Gonzalez Perez, Kurt Hecher, Mark A. Hanson, A. Metin Gülmezoglu, Lawrence D. Platt
Journal: PLoS Medicine (2021)

The title and caption of Table 12 does not correspond to the table content.
Military looks toward 1985 in ongoing defoliant study
Authors: P. Gunby
Journal: JAMA (1984)

The hot topic at the moment in the ongoing Agent Orange controversy (<i>JAMA</i>[MEDICAL NEWS] 1979; 241:1443-1444) is recently-released preliminary data from an Air Force study. This is a study of men who loaded and flew the aircraft that sprayed the Agent Orange defoliant during the war in Southeast Asia in the 1960s and early 1970s (<i>JAMA</i>[MEDICAL NEWS] 1979;242:593-597). The operation, called "Ranch Hand," was designed to deny cover and crops to opposing forces in Vietnam. The participants are being compared with a control group matched for age, race, military specialty, and service in Vietnam. And, even as these just-released "baseline morbidity study results" are being widely discussed, the Air Force already is at work revising its health history questionnaire and physical examination formats in preparation for next year's followup studies. All of this is against a backdrop of court proceedings beginning in May to try suits brought by