tbuckley/cabot-search huggingface dataset:
원저 / 급성 A 형 간염의 군인에서의 다발생 ( Outbreak ) : 암상, 역학적 연구
Authors: 한성희(Sung Hee Han), 이숭환(Soong Hwan Lee), 노병주(Byung Joo Roh), 심성춘(Seong Chun Shim), 조승철(Seung Chul Cho), 손주현(Joo Hyun Sohn), 이동후(Dong Hoo Lee), 기춘석(Choon Suhk Kee)
Journal: Clinical and Molecular Hepatology (2001)

Background / Aims : Increasing the susceptibility of young populations to HAV infection could result in an outbreak in a high-risk group. The author investigated the characteristics of hepatitis A outbreaks among Korean military personnel to obtain the fundamental data for determining the necessity for selective HAV vaccination. Methods : A case was defined as a person who had an onset of an illness compatible with acute viral hepatitis A between 4 February and 6 April 1998. Results : A widespread outbreak of hepatitis A affected 102 military personnel. The epidemic curve indicated a common-source exposure in the initial stage. At the end of the first month of the initial onset, the occurrence was specific to the location of the military post. Investigation suggested that contamination most likely occurred prior to the local distribution of food. The mean age was 23 years. The overall attack rate was 91 cases per 10000 persons at risk. All cases were jaundiced. The most frequently reported symptoms included icteric sclerae, daek urine,anorexia, malaise and fatigue, nausea, fever,abdominal pain, headache, upper respiratory symptoms, vomiting, itching, diarrhea, light-colores stools, myalgia, arthralgia, and skinrash. The laboratory test showed the serum total bilirubin of 5.5 mg./dL, AST of 344 IU/L, and ALT of 868 IU/L(mean value). Conclusion : All patients were clinically apparently diseased with jaundice and were completely recovered. The outbreak was food borne common-source exposure. The changing epidemiology hepatitis A in Korea calls for the economic evaluation of costs and benefits for selective HAV vaccination in high risk adult groups including military personnel.
Long-term survival of patients with mantle cell lymphoma after autologous haematopoietic stem-cell transplantation in first remission: a post-hoc analysis of an open-label, multicentre, randomised, phase 3 trial
Authors: Anna-Katharina Zoellner, Michael Unterhalt, Stephan Stilgenbauer, Kai Hübel, Catherine Thieblemont, Bernd Metzner, Max Topp, Lorenz Truemper, Christian Schmidt, Kamal Bouabdallah, Jürgen Krauter, Georg Lenz, Jan Dürig, Vibeke Vergote, Kerstin Schäfer-Eckart, Marc André, Hanneke C Kluin-Nelemans, Achiel van Hoof, Wolfram Klapper, Wolfgang Hiddemann, Martin Dreyling, Eva Hoster
Journal: The Lancet Haematology (2021)
Intakes of Fish and Long-Chain n-3 Polyunsaturated Fatty Acid Supplements During Pregnancy and Subsequent Risk of Type 2 Diabetes in a Large Prospective Cohort Study of Norwegian Women
Authors: Jannike Øyen, Anne Lise Brantsæter, Ole Jakob Nøstbakken, Kåre I. Birkeland, Margareta Haugen, Lise Madsen, Grace M. Egeland
Journal: Diabetes Care (2021)

OBJECTIVE To investigate associations between intakes of total fish, lean fish, fatty fish, and long-chain n-3 polyunsaturated fatty acid (LCn-3PUFA) supplements and risk of type 2 diabetes in women after pregnancy. Furthermore, we sought to compare the estimated intakes of methylmercury (MeHg) and sum of dioxins and dioxin-like polychlorinated biphenyls (dl-PCBs) with tolerable weekly intakes (TWI). RESEARCH DESIGN AND METHODS Women free of diabetes at baseline (n = 60,831) who participated in the population-based Norwegian Mother, Father and Child Cohort Study (MoBa) were prospectively evaluated for incident type 2 diabetes, identified on the basis of medication usage &amp;gt;90 days after delivery, ascertained through the Norwegian Prescription Database. Dietary intake data were obtained with a validated 255-item food-frequency questionnaire (FFQ), which assessed habitual diet during the first 4–5 months of pregnancy. Intakes of MeHg and sum of dioxins and dl-PCBs were derived with use of a contaminant database and the FFQ. RESULTS Median age was 31 years (interquartile range 27, 34) at time of delivery, and follow-up time was 7.5 years (6.5, 8.5). Type 2 diabetes occurred in 683 (1.1%) participants. Multivariable Cox regression analyses identified lower risk of type 2 diabetes with increasing energy-adjusted lean fish intake (25 g/1,000 kcal: hazard ratio 0.71, 95% CI 0.53–0.95, P = 0.022). However, in stratified analyses, a lower risk was found only in women with prepregnancy BMI ≥25 kg/m2. There were no associations between intake of total fish, fatty fish, or LCn-3PUFA supplements and type 2 diabetes. MeHg intake was low, but the intake of the sum of dioxins and dl-PCBs (picograms of toxic equivalents/kilograms of body weight/week) exceeded the TWI set by the European Food Safety Authority (EFSA) for the majority of participants. CONCLUSIONS Intake of lean fish, but not fatty fish or LCn-3PUFA supplements, was associated with lower risk of pharmacologically treated type 2 diabetes in Norwegian women who were overweight or obese. Fatty fish, which contain dioxins and dl-PCBs, did not increase the risk of type 2 diabetes, but the exceedance of the EFSA TWI for dioxins and dl-PCBs is a health concern.
Effectiveness of psychological interventions in prison to reduce recidivism: a systematic review and meta-analysis of randomised controlled trials
Authors: Gabrielle Beaudry, Rongqin Yu, Amanda E Perry, Seena Fazel
Journal: The Lancet Psychiatry (2021)

Repeat offending, also known as criminal recidivism, in people released from prison has remained high over many decades. To address this, psychological treatments have been increasingly used in criminal justice settings; however, there is little evidence about their effectiveness. We aimed to evaluate the effectiveness of interventions in prison to reduce recidivism after release.
Primary Cutaneous Endometriosis Presenting as an Umbilical Nodule
Authors: Peter G. Bittar, Katherine T. Hrynewycz, Elizabeth A. Bryant
Journal: JAMA Dermatology (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Abstract 17193: Absence of Thoracic Aortic Disease In ACTA2R149C/+ Mice is Associated With Defective Release of Mutant Smooth Muscle α-actin From the Chaperonin Complex
Authors: Dianna M Milewicz, Jiyuan Chen, Kaveeta Kaw, Abhijnan Chattopadhyay, Xue Yan Duan, Zhen Zhou, Callie Kwartler, Kathleen Trybus, James Stull, Kristine Kamm, Shuangtao Ma
Journal: Circulation (2019)

Rationale: The most common mutation in ACTA2 is p.Arg149Cys, which predisposes individuals to either thoracic aortic disease or premature onset coronary artery disease but rarely both diseases. Obj...
The Gut Microbiome, Metformin, and Aging
Authors: Sri Nitya Reddy Induri, Payalben Kansara, Scott C. Thomas, Fangxi Xu, Deepak Saxena, Xin Li
Journal: The Annual Review of Pharmacology and Toxicology (2021)

Metformin has been extensively used for the treatment of type 2 diabetes, and it may also promote healthy aging. Despite its widespread use and versatility, metformin's mechanisms of action remain elusive. The gut typically harbors thousands of bacterial species, and as the concentration of metformin is much higher in the gut as compared to plasma, it is plausible that microbiome-drug-host interactions may influence the functions of metformin. Detrimental perturbations in the aging gut microbiome lead to the activation of the innate immune response concomitant with chronic low-grade inflammation. With the effectiveness of metformin in diabetes and antiaging varying among individuals, there is reason to believe that the gut microbiome plays a role in the efficacy of metformin. Metformin has been implicated in the promotion and maintenance of a healthy gut microbiome and reduces many age-related degenerative pathologies. Mechanistic understanding of metformin in the promotion of a healthy gut microbiome and aging will require a systems-level approach.
Abstract 5900: Differential Effect of Ticagrelor versus Clopidogrel on the Prevalence of High On-Treatment Platelet Reactivity: Results From the Onset-offset Study
Authors: Kevin Bliden, Udaya Tantry, Mark Antonino, Elizabeth Mahla, Tania Gesheff, Kathleen Butler, Cheryl Wei, Paul Gurbel
Journal: Circulation (2009)

Background: High on-treatment platelet reactivity to ADP (HPR) has been strongly linked to adverse event occurrence following coronary artery stenting in patients treated with aspirin and clopidogr...
A New Triple Threat
Authors: Jayshil J. Patel
Journal: Annals of Internal Medicine (2021)

On Being a DoctorAugust 2021A New Triple ThreatJayshil J. Patel, MDJayshil J. Patel, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M21-1042 Audio Reading - “A New Triple Threat” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads “A New Triple Threat” by Jayshil J. Patel, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Since the 1960s, the ideal academic physician has been referred to as an “academic triple threat.” Despite the word “threat,” the term is meant to have a positive connotation. It describes a physician who conducts original research, teaches medical students and residents, and provides exemplary clinical care.I aspired to be an academic triple threat. About 9 years ago, I expanded upon my role as a clinical educator. In addition to caring for critically ill patients and teaching, I began conducting original clinical research. I learned study design and grantsmanship. Observational studies led to an investigator-initiated randomized controlled trial. Modest ... Author, Article, and Disclosure InformationAffiliations: Corresponding Author: Jayshil J. Patel, MD, Associate Professor of Medicine, Division of Pulmonary & Critical Care Medicine, Medical College of Wisconsin, 8701 West Watertown Plank Road, HUB for Collaborative Medicine, Eighth Floor, Milwaukee, WI 53226; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement Audio Reading - “A New Triple Threat” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads “A New Triple Threat” by Jayshil J. Patel, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics August 2021Volume 174, Issue 8Page: 1175-1176 ePublished: 17 August 2021 Issue Published: August 2021 Copyright & PermissionsCopyright © 2021 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
COVID-19 Case Age Distribution: Correction for Differential Testing by Age
Authors: David N. Fisman, Amy L. Greer, Gabrielle Brankston, Michael Hillmer, Sheila F. O’Brien, Steven J. Drews, Ashleigh R. Tuite
Journal: Annals of Internal Medicine (2021)

Despite expected initial universal susceptibility to a novel pandemic pathogen like SARS-CoV-2, the pandemic has been characterized by higher observed incidence in older persons and lower incidence in children and adolescents.To determine whether differential testing by age group explains observed variation in incidence.Population-based cohort study.Ontario, Canada.Persons diagnosed with SARS-CoV-2 and those tested for SARS-CoV-2.Test volumes from the Ontario Laboratories Information System, number of laboratory-confirmed SARS-CoV-2 cases from the Integrated Public Health Information System, and population figures from Statistics Canada. Demographic and temporal patterns in incidence, testing rates, and test positivity were explored using negative binomial regression models and standardization. Sources of variation in standardized ratios were identified and test-adjusted standardized infection ratios (SIRs) were estimated by metaregression.Observed disease incidence and testing rates were highest in the oldest age group and markedly lower in those younger than 20 years; no differences in incidence were seen by sex. After adjustment for testing frequency, SIRs were lowest in children and in adults aged 70 years or older and markedly higher in adolescents and in males aged 20 to 49 years compared with the overall population. Test-adjusted SIRs were highly correlated with standardized positivity ratios (Pearson correlation coefficient, 0.87 [95% CI, 0.68 to 0.95]; P < 0.001) and provided a case identification fraction similar to that estimated with serologic testing (26.7% vs. 17.2%).The novel methodology requires external validation. Case and testing data were not linkable at the individual level.Adjustment for testing frequency provides a different picture of SARS-CoV-2 infection risk by age, suggesting that younger males are an underrecognized group at high risk for SARS-CoV-2 infection.Canadian Institutes of Health Research.
The Evolving Genomic Landscape of Esophageal Squamous Cell Carcinoma Under Chemoradiotherapy
Authors: Hidenari Hirata, Atsushi Niida, Nobuyuki Kakiuchi, Ryutaro Uchi, Keishi Sugimachi, Takaaki Masuda, Tomoko Saito, Shun-Ichiro Kageyama, Yushi Motomura, Shuhei Ito, Tadamasa Yoshitake, Daisuke Tsurumaru, Yusuke Nishimuta, Akira Yokoyama, Takanori Hasegawa, Kenichi Chiba, Yuichi Shiraishi, Junyan Du, Fumihito Miura, Masaru Morita, Yasushi Toh, Masakazu Hirakawa, Yoshiyuki Shioyama, Takashi Ito, Tetsuo Akimoto, Satoru Miyano, Tatsuhiro Shibata, Masaki Mori, Yutaka Suzuki, Seishi Ogawa, Kousei Ishigami, Koshi Mimori
Journal: Cancer Research (2021)

Esophageal squamous cell carcinoma (ESCC) often recurs after chemoradiotherapy, and the prognosis of ESCC after chemoradiotherapy has not improved over the past few decades. The mutation process in chemoradiotherapy-resistant clones and the functional relevance of genetic alterations remain unclear. To address these problems, we performed whole-exome sequencing of 52 tumor samples from 33 patients with ESCC who received radiotherapy combined with 5-fluorouracil/platinum. In multiregion analyses of pretreatment and locally recurrent lesions from five cases, most driver gene-altered clones remained under chemoradiotherapy selection pressure, while few driver gene alterations were acquired at recurrence. The mutation signatures of recurrent ESCC, including increased deletion frequency and platinum dose-dependent base substitution signatures, were substantially different from those of primary ESCC and reflected the iatrogenic impacts of chemoradiotherapy. Single-region analysis of 28 pretreatment tumors indicated that focal copy-number gain at the MYC locus was significantly associated with poor progression-free survival and overall survival after chemoradiotherapy. MYC gain remained throughout the chemoradiotherapy course and potentially contributes to intrinsic resistance to chemoradiotherapy. Consistent with these findings, MYC copy number and mRNA and protein levels in ESCC cell lines correlated positively with resistance to radiotherapy, and MYC knockdown improved sensitivity to radiotherapy. Overall, these data characterize the clonal evolution process induced by chemoradiotherapy and clinically relevant associations for genetic alterations in ESCC. These findings increase our understanding of therapeutic resistance and support the rationale for precision chemoradiotherapy. SIGNIFICANCE: Whole-exome sequencing reveals the genetic evolution of ESCC during chemoradiotherapy, highlighting MYC gain in pretreatment tumors as a potential marker of therapy resistance.
Effect of Low-Intensity vs High-Intensity Walking Exercise on Walk Distance in Patients With Peripheral Artery Disease
Authors: Azmi Rahman, Sajeenth Vishnu K
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
27510 Dysbiotic skin microbiome network of individual mediated host response to pollution stress
Authors: Lu Wang, Yi-Ning Xu, Yabin Chen, Jinsong Zhang, Mingming Pu, Tingyan Mi, Yaping Du, Chandraprabha Doraiswamy, Tao Zeng, Luonan Chen
Journal: Journal of the American Academy of Dermatology (2021)
FILIP1L Loss Is a Driver of Aggressive Mucinous Colorectal Adenocarcinoma and Mediates Cytokinesis Defects through PFDN1
Authors: Mijung Kwon, Genesaret Rubio, Nicholas Nolan, Peter Auteri, Jean Arly Volmar, Asha Adem, Parisa Javidian, Zhongren Zhou, Michael P. Verzi, Sharon R. Pine, Steven K. Libutti
Journal: Cancer Research (2021)

Abstract Aneuploid mucinous colorectal adenocarcinoma (MAC) is an aggressive subtype of colorectal cancer with poor prognosis. The tumorigenic mechanisms in aneuploid MAC are currently unknown. Here we show that downregulation of Filamin A–interacting protein 1-like (FILIP1L) is a driver of MAC. Loss of FILIP1L increased xenograft growth, and, in colon-specific knockout mice, induced colonic epithelial hyperplasia and mucin secretion. The molecular chaperone prefoldin 1 (PFDN1) was identified as a novel binding partner of FILIP1L at the centrosomes throughout mitosis. FILIP1L was required for proper centrosomal localization of PFDN1 and regulated proteasome-dependent degradation of PFDN1. Importantly, increased PFDN1, caused by downregulation of FILIP1L, drove multinucleation and cytokinesis defects in vitro and in vivo, which were confirmed by time-lapse imaging and 3D cultures of normal epithelial cells. Overall, these findings suggest that downregulation of FILIP1L and subsequent upregulation of PFDN1 is a driver of the unique neoplastic characteristics in aggressive aneuploid MAC. Significance: This study identifies FILIP1L as a tumor suppressor in mucinous colon cancer and demonstrates that FILIP1L loss results in aberrant stabilization of a centrosome-associated chaperone protein to drive aneuploidy and disease progression.
Anticancer bispecific antibody R&amp;D advances: a study focusing on research trend worldwide and in China
Authors: Zhonghan Zhang, Fan Luo, Jiaxin Cao, Feiteng Lu, Yang Zhang, Yuxiang Ma, Kangmei Zeng, Li Zhang, Hongyun Zhao
Journal: Journal of Hematology & Oncology (2021)

The bispecific antibody (bsAbs) research around the world has undergone great changes. We analyzed the global trend of bsAbs research and compared the differences in clinical research of bsAbs between China and worldwide. BsAbs research clinical trials information was retrieved through the online open-resource clinical trial registration platform. Research information including organizations, identity numbers, locations, phases, participating centers, conditions, status, enrollment, targets, spectrums of mechanism of action (MOA), and start date was collected. Clinical trials were divided into two categories based on the attributes of pharmaceutical companies (international or China-initiated or involved). From 1997 to 2020, 272 clinical trials regarding bsAbs research were retrieved. Twenty-nine percent of the studies were contributed by companies from Chinese institutions, which followed the USA and ranked second. The clinical trials of bsAbs are mainly concentrated on phase I (n = 161), phase I/II (n = 54), and phase II (n = 51), and the number of phase III trials is still rare (n = 4). Tumor species distribution analysis shows that there are significantly higher focuses on gastric cancer (n = 18), esophageal/gastroesophageal junction cancer (n = 16), bladder cancer (n = 10), biliary malignant tumor (n = 8), nasopharyngeal cancer (n = 6), and thymic cancer (n = 2) in China. BsAbs target and spectrums of MOA analysis showed that international companies mainly focus on bsAbs with CD3-based (n = 63) target with MOA of T-cell redirection, while researches in China pay more attention to PD-1 (n = 9)/PD-L1 (n = 7) axises with MOA of double immune checkpoint blocking. Global bsAbs research increased rapidly during the 1997 to 2020 period. The developed countries in America and Europe are leading the trend of bsAbs research. Anticancer bsAbs clinical research in China is booming and chasing after the world trend.
Right Ventricular Function in Transcatheter Edge-to-Edge Tricuspid Valve Repair
Authors: Mathias Orban, Stefanie Wolff, Daniel Braun, Lukas Stolz, Satoshi Higuchi, Konstantin Stark, Michael Mehr, Thomas J. Stocker, Dominic Dischl, Clemens Scherer, Enzo Lüsebrink, Julius Steffen, Martin Orban, Christian Hagl, Steffen Massberg, Michael Näbauer, Jörg Hausleiter
Journal: JACC. Cardiovascular imaging (2021)