tbuckley/cabot-search huggingface dataset:
COVID-19
Authors: Joan Baranow
Journal: JAMA (2021)

They like dark, wet places in the house to hide in, dividing, crowding out the prior tenants.Unasked, they plaster over walls, paste the rooms with stucco.O 2 wants to get out but can't push through new sheetrock.Meanwhile, outside, the flow of traffic slows, blood cells en route to the heart sputter, the city lights blink out until the whole power plant shuts down.Auxiliary generators brought in aren't enough.What's left isn't a metaphor.It's us.
Antibody Titers Before and After a Third Dose of the SARS-CoV-2 BNT162b2 Vaccine in Adults Aged ≥60 Years
Authors: Noa Eliakim-Raz, Yaara Leibovici-Weisman, Amos Stemmer, Asaf Ness, Muhammad Awwad, Nassem Ghantous, Salomon M. Stemmer
Journal: JAMA (2021)

Antibody Titers Before and After a Third Dose of the SARS-CoV-2 BNT162b2 Vaccine in Adults Aged ≥60 YearsThe durability of response to the SARS-CoV-2 BNT162b2 vaccine (Pfizer-BioNTech) in adults aged 60 years and older has yet to be determined.The immune response to 2 doses of BNT162b2 is lower in individuals aged 65 to 85 years vs 18 to 55 years. 1 Among 4868 health care workers receiving 2 BNT162b2 doses, a significant waning of the humoral response (IgG, neutralizing antibodies) within 6 months of the second dose was observed, especially among adults aged 65 years and older. 2 After a fourth SARS-CoV-2 wave in Israel, the Israeli Ministry of Health authorized, at the end of July 2021, a third BNT162b2 vaccine dose for individuals aged 60 years and older, which was subsequently expanded to younger age groups.We assessed antispike (anti-S) IgG antibody titers before and after a third BNT162b2 dose in individuals aged 60 years and older because this population is at high risk of developing severe SARS-CoV-2 disease and was the first to receive authorization for a third dose.
Analysis of Performance Trends from 2010–2019 on the American Board of Internal Medicine Nephrology Certifying Exam
Authors: Jeffrey S. Berns, Weifeng Weng, Bernard G. Jaar, Rebecca S. Lipner, Bradley G. Brossman, Furman S. McDonald
Journal: Journal of the American Society of Nephrology (2021)

The pass rate on the American Board of Internal Medicine (ABIM) nephrology certifying exam has declined and is among the lowest of all internal medicine (IM) subspecialties. In recent years, there have also been fewer applicants for the nephrology fellowship match.This retrospective observational study assessed how changes between 2010 and 2019 in characteristics of 4094 graduates of US ACGME-accredited nephrology fellowship programs taking the ABIM nephrology certifying exam for the first time, and how characteristics of their fellowship programs were associated with exam performance. The primary outcome measure was performance on the nephrology certifying exam. Fellowship program pass rates over the decade were also studied.Lower IM certifying exam score, older age, female sex, international medical graduate (IMG) status, and having trained at a smaller nephrology fellowship program were associated with poorer nephrology certifying exam performance. The mean IM certifying exam percentile score among those who subsequently took the nephrology certifying exam decreased from 56.7 (SD, 27.9) to 46.1 (SD, 28.7) from 2010 to 2019. When examining individuals with comparable IM certifying exam performance, IMGs performed less well than United States medical graduates (USMGs) on the nephrology certifying exam. In 2019, only 57% of nephrology fellowship programs had aggregate 3-year certifying exam pass rates ≥80% among their graduates.Changes in IM certifying exam performance, certain trainee demographics, and poorer performance among those from smaller fellowship programs explain much of the decline in nephrology certifying exam performance. IM certifying exam performance was the dominant determinant.
Understanding Associations Between Attention-Deficit/Hyperactivity Disorder and Traumatic Brain Injury—Reply
Authors: Robert F. Asarnow, Nina Newman, Erica Su, Robert E. Weiss
Journal: JAMA Pediatrics (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Lifestyle considerations in multiple myeloma
Authors: Yael N. Shapiro, Jeffrey M. Peppercorn, Andrew J. Yee, Andrew R. Branagan, Noopur S. Raje, Elizabeth K. O’ Donnell
Journal: Blood Cancer Journal (2021)

As the prognosis for multiple myeloma (MM) has significantly improved and patients remain on therapy longer, there is a need for supportive care interventions to optimize patient quality of life (QOL) and functional status over the course of cancer treatment. MM is characterized by a significant symptom burden and a relatively lower QOL compared to other cancers. This review evaluates the role of healthy lifestyle behaviors in improving both the physical functioning and psychological well-being of the MM population. We (1) describe the current literature on physical activity, weight management, diet, sleep, and substance use in the context of MM, (2) present important considerations for incorporating lifestyle factors into clinical practice, and (3) identify directions for future research. Developing MM-specific guidelines for modifiable lifestyle changes that take into account both the length of treatment and the unique disease features (i.e. osteolytic lesions and anemia) may provide a promising path for improved patient QOL and functioning.
AKI in Kuwait: Incidence, Causes, Management, and Outcomes - A Prospective Observational Study
Authors: Ali AlSahow, Anas M. Al Yousef, Bassam A. Alhelal, Heba Al Rajab, Ahmed Alqallaf, Yousif Bahbahani, Monther M. Alsharekh, Basem Said, Mohamed A. Osman, Ahmed M. Mazroue, Ali S. Abdelzaher, Alaa T. Abdelmoteleb, Gamal Nessim, Emad Abdallah, Rajeev K. Malhotra
Journal: Journal of the American Society of Nephrology (2021)

Background: Little is known about AKI epidemiology, causes, management and outcome in Kuwait. We report that. Methods: Demographics, comorbidities, treatment and 4 weeks outcome data for nephrology referrals for AKI in 7 public hospitals from 1/Jan-30/Apr/2021 prospectively collected and analyzed Results: Total number of AKI referrals was 1298, that is 3.3% of hospital admissions. Community acquired cases were 12.5%. Males were 57%, mean age 64 (52% > 65), and Kuwaiti citizens 65%. DM affected 71%, HTN 74%, and cardiac disease 36% of patients. Mean baseline eGFR before AKI was 62. Baseline eGFR   60, had mean baseline eGFR of 35 (vs 90), were older (68 vs 60 with 61% above age 65 vs 41%), 81% had DM (vs 60%), 85% had HTN (vs 63%), 46% had cardiac disease (vs 24%). Cause of AKI was pre-renal / ischemic ATN in 87%, COVID-19 related in 8%, contrast-associated in 6%, drug-induced AIN in 5% of cases. Many had more than one possible cause. Sepsis was most common precipitating factor seen in 67% then volume depletion in 50%. Many had more than one factor. IV fluids used in 73% (less in lower eGFR group), IV diuretics in 46% (more in lower eGFR group), IV vasopressors in 40% (less in lower eGFR group) and steroids in 33%. KRT needed in 33%, more in patients who used diuretics or vasopressors. Volume overload and electrolytes / acid-base disorders were most common indication (75% and 79% respectively). CKRT was modality of choice in 85%, however, in 52% of CKRT, conventional HD not used due to lack of dialysate source in some sites. At 30 days, mean eGFR was 42%, with complete recovery in 34%, and 38% failed to recover at all. Death occurred in 31%, 55% had baseline eGFR > 60, and 50% of deaths occurred while still on KRT. Non-survivors were older and had higher use of vasopressors. AKI associated mortality in 25% of total hospital mortality and in 31% of ICU / CCU mortality. Conclusions: AKI is common. Most cases hospital-acquired. Use of resources (medications, critical care, KRT) and rates of mortality are high. Kuwaiti citizens represent 1/3 of the population and 2/3 of AKI cases and almost 70% of deaths.
TCT-374 Prosthetic Valve Endocarditis Following Low-Risk Transcatheter Aortic Valve Replacement
Authors: Giorgio Medranda, Toby Rogers, Cheng Zhang, Corey Shea, Syed Ali, Brian Case, Itsik Ben-Dor, Lowell Satler, Ron Waksman
Journal: Journal of the American College of Cardiology (2021)
Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease
Authors: Daniel Erny, Nikolaos Dokalis, Charlotte Mezö, Angela Castoldi, Omar Mossad, Ori Staszewski, Maximilian Frosch, Matteo Villa, Vidmante Fuchs, Arun Mayer, Jana Neuber, Janika Sosat, Stefan Tholen, Oliver Schilling, Andreas Vlachos, Thomas Blank, Mercedes Gomez de Agüero, Andrew J. Macpherson, Edward J. Pearce, Marco Prinz
Journal: Cell Metabolism (2021)
生体模倣硝子体代替物としての安定なオキシム架橋ヒアルロナン系ヒドロゲル【JST・京大機械翻訳】
Authors: E G Baker Alexander, Cui Hong, G Ballios Brian, Ing Sonja, Yan Peng, Wolfer Joe, Wright Thomas, Dang Mickael, Y Gan Nicola, J Cooke Michael, Ortin-Martinez Arturo, A Wallace Valerie, van der Kooy Derek, Devenyi Robert, S Shoichet Molly
Journal: Biomaterials (2021)
TCT-283 Large-Bore Arterial Access Closure After Transcatheter Aortic Valve Replacement: A Systematic Review and Network Meta-Analysis
Authors: Claudio Montalto, Andrea Munafò, Luca Arzuffi, Francesco Soriano, Antonio Mangieri, Giovanni Luigi De Maria, Francesco Burzotta, Antonio Colombo, Azeem Latib, Jacopo Oreglia, Adrian Banning, Italo Porto, Gabriele Crimi
Journal: Journal of the American College of Cardiology (2021)
Mucosal‐associated invariant T‐cell tumor infiltration predicts long‐term survival in cholangiocarcinoma
Authors: Christine L. Zimmer, Iva Filipovic, Martin Cornillet, Colm J. O’Rourke, Lena Berglin, Hannes Jansson, Dan Sun, Otto Strauss, Laura Hertwig, Helene Johansson, Erik von Seth, Ernesto Sparrelid, Joana Dias, Hans Glaumann, Espen Melum, Ewa C. Ellis, Johan K. Sandberg, Jesper B. Andersen, Annika Bergquist, Niklas K. Björkström
Journal: Hepatology (2021)

Abstract Background and Aims Cholangiocarcinoma (CCA) is a malignancy arising from biliary epithelial cells of intra‐ and extrahepatic bile ducts with dismal prognosis and few nonsurgical treatments available. Despite recent success in the immunotherapy‐based treatment of many tumor types, this has not been successfully translated to CCA. Mucosal‐associated invariant T (MAIT) cells are cytotoxic innate‐like T cells highly enriched in the human liver, where they are located in close proximity to the biliary epithelium. Here, we aimed to comprehensively characterize MAIT cells in intrahepatic (iCCA) and perihilar CCA (pCCA). Approach and Results Liver tissue from patients with CCA was used to study immune cells, including MAIT cells, in tumor‐affected and surrounding tissue by immunohistochemistry, RNA‐sequencing, and multicolor flow cytometry. The iCCA and pCCA tumor microenvironment was characterized by the presence of both cytotoxic T cells and high numbers of regulatory T cells. In contrast, MAIT cells were heterogenously lost from tumors compared to the surrounding liver tissue. This loss possibly occurred in response to increased bacterial burden within tumors. The residual intratumoral MAIT cell population exhibited phenotypic and transcriptomic alterations, but a preserved receptor repertoire for interaction with tumor cells. Finally, the high presence of MAIT cells in livers of iCCA patients predicted long‐term survival in two independent cohorts and was associated with a favorable antitumor immune signature. Conclusions MAIT cell tumor infiltration associates with favorable immunological fitness and predicts survival in CCA.
Prevalence of multidimensional frailty and pre-frailty in older people in different settings: A systematic review and meta-analysis
Authors: Nicola Veronese, Carlo Custodero, Alberto Cella, Jacopo Demurtas, Sabrina Zora, Stefania Maggi, Mario Barbagallo, Carlo Sabbà, Luigi Ferrucci, Alberto Pilotto
Journal: Ageing Research Reviews (2021)
Enclosed Zone Flow-Mediated Vasodilation (ezFMD) is a Novel Noninvasive Method for Assessment of Endothelial Function
Authors: Idei Naomi, Higashi Yukihito, Fujimura Noritaka, Maruhashi Tatsuya, Mikami Shinsuke, Iwamoto Yumiko, Hata Takaki, Soga Junko, Fujii Yuichi, Hidaka Takayuki, Noma Kensuke, Ukawa Teiji, Tsuji Toshio, Yoshizumi Masao, Kihara Yasuki
Journal: Circulation (2012)
TCT-430 The Impact of Left Ventricular Outflow Tract Calcium on Hemodynamic Status and Clinical Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement With a Contemporary Self-Expanding Valve
Authors: Giorgio Medranda, Toby Rogers, Brian Case, Syed Ali, Cheng Zhang, John Wang, Gaby Weissman, Itsik Ben-Dor, Lowell Satler, Ron Waksman
Journal: Journal of the American College of Cardiology (2021)
COVID-Related Renal Thrombotic Microangiopathy: Role of Plasma Exchange
Authors: Janame J. Kottey, Niraj K. Yadav, Rama Kethineni, Sarah Gilligan, Martin C. Gregory, Tahir Zaman, Marc Barry, Adhish Agarwal, Josephine Abraham
Journal: Journal of the American Society of Nephrology (2021)

Kottey, Janame J.; Yadav, Niraj K.; Kethineni, Rama; Gilligan, Sarah; Gregory, Martin C.; Zaman, Tahir; Barry, Marc; Agarwal, Adhish; Abraham, Josephine Author Information
TCT-271 Outcomes of Transcatheter Aortic Valve Replacement Using Balloon vs Self-Expandable Valves Stratified by Center Valve Preference – Insights From the Multicenter Aortic+Mitral TRAnsCatheter (AMTRAC) Registry
Authors: Guy Witberg, Alexander Sedaghat, Victor Mauri, Dabit Arzamendi, Rodrigo Estevez-Loureiro, Tomás Benito-González, Martin Andreas, Philipp Ruile, Matjaz Bunc, Darren Mylotte, Giuseppe Tarantini, Luis Nombela-Franco, Marco Barbanti, Lars Sondergaard, Nicolas Van Mieghem, Ariel Finkelstein, Ran Kornowski
Journal: Journal of the American College of Cardiology (2021)
Bortezomib, Lenalidomide and Dexamethasone (VRd) Followed By Ciltacabtagene Autoleucel Versus Vrd Followed By Lenalidomide and Dexamethasone (Rd) Maintenance in Patients with Newly Diagnosed Multiple Myeloma Not Intended for Transplant: A Randomized, Phase 3 Study (CARTITUDE-5)
Authors: Dominik Dytfeld, Binod Dhakal, Mounzer Agha, Salomon Manier, Michel Delforge, Steven Kuppens, Salma Afifi, William Deraedt, Agne Taraseviciute-Morris, Jordan M. Schecter, Jane Gilbert, Fevzi Yalniz, Erika Florendo, Lida Pacaud, Vania Hungria, Saad Z. Usmani, Maria-Victoria Mateos
Journal: Blood (2021)
The Tip60 histone acetyltransferase is essential for the acetylation and activation of the ATM protein kinase
Authors: Brendan D. Price, Yingli Sun, Xiaofeng Jiang, Norvin Fernandes
Journal: Cancer Research (2006)

2307  The ATM protein kinase is essential for the repair of DNA strand breaks. The repair of DNA strand breaks involves the remodeling of the chromatin structure. Structural changes in chromatin during DNA repair have been linked to post-translational modification of histones by phosphorylation, methylation or acetylation. These histone modifications can create binding sites for DNA repair complexes, including 53BP1, NuA4 and INO80. In addition, activation of the ATM protein kinase can be brought about by changes in chromatin structure. However, the signal transduction pathway linking DNA strand breaks to activation of ATM’s kinase activity is not clearly defined. Here, we investigated the role of the Tip60 Histone Acetyltranferase (HAT), a component of the NuA4 complex, in the activation of the ATM protein kinase. ATM is rapidly acetylated in a Tip60-dependent manner following DNA damage. Suppression of Tip60 blocks the activation of ATM’s kinase activity and prevents the ATM-dependent phosphorylation of p53 and chk2. Further, inactivation of Tip60 sensitizes cells to DNA damage. ATM and Tip60 exist as a preformed complex in cells; however, interaction between ATM and Tip60 is not regulated in response to DNA damage. Instead, the HAT activity of the ATM-Tip60 complex is specifically activated by DNA damage. This interaction between ATM and Tip60 requires the conserved FATC domain at the c-terminus of the ATM protein. Finally, the activation of Tip60 requires the chromodomain of Tip60, a domain with the potential to associate with methyl-lysine residues on histones at sites of DNA damage. The results demonstrate that Tip60 is required for the acetylation and activation of the ATM-Tip60 complex following DNA damage. Further, our results define the Tip60 histone acetyltransferase as a DNA damage response protein. This activation of ATM requires the chromodomain of Tip60, suggesting that the ATM-Tip60 complex associates with exposed methyl-lysine residues on histones at sites of DNA damage. This interaction between Tip60 and histones at sites of DNA damage may then activate Tip60’s HAT activity, leading to the acetylation and activation of the ATM protein kinase. These results describe a mechanism to link changes in chromatin structure to the activation of ATM-dependent DNA damage response pathways.
The Loneliness of the Long-Term Care Giver
Authors: C Levine
Journal: New England Journal of Medicine (1999)

I am standing at a bank of phones, desperately punching in codes and numbers. Each time, the line goes dead. “Why can't I get through to anyone?” I think. “I must be doing something wrong.”I wake up. This time it's only a dream. But the dream originated in a real experience. On the icy morning of January 15, 1990, my husband lay comatose in the emergency room of a community hospital after an automobile accident. Uninjured but dazed, I stood at a bank of hospital phones trying to reach people who could help me transfer him to a major . . .
Annual Report to the Nation on the Status of Cancer, Part 2: Patient Economic Burden Associated With Cancer Care
Authors: K Robin Yabroff, Angela Mariotto, Florence Tangka, Jingxuan Zhao, Farhad Islami, Hyuna Sung, Recinda L Sherman, S Jane Henley, Ahmedin Jemal, Elizabeth M Ward
Journal: JNCI Journal of the National Cancer Institute (2021)

The American Cancer Society, National Cancer Institute, Centers for Disease Control and Prevention, and North American Association of Central Cancer Registries provide annual information about cancer occurrence and trends in the United States. Part 1 of this annual report focuses on national cancer statistics. This study is part 2, which quantifies patient economic burden associated with cancer care.We used complementary data sources, linked Surveillance, Epidemiology, and End Results-Medicare, and the Medical Expenditure Panel Survey to develop comprehensive estimates of patient economic burden, including out-of-pocket and patient time costs, associated with cancer care. The 2000-2013 Surveillance, Epidemiology, and End Results-Medicare data were used to estimate net patient out-of-pocket costs among adults aged 65 years and older for the initial, continuing, and end-of-life phases of care for all cancer sites combined and separately for the 21 most common cancer sites. The 2008-2017 Medical Expenditure Panel Survey data were used to calculate out-of-pocket costs and time costs associated with cancer among adults aged 18-64 years and 65 years and older.Across all cancer sites, annualized net out-of-pocket costs for medical services and prescriptions drugs covered through a pharmacy benefit among adults aged 65 years and older were highest in the initial ($2200 and $243, respectively) and end-of-life phases ($3823 and $448, respectively) and lowest in the continuing phase ($466 and $127, respectively), with substantial variation by cancer site. Out-of-pocket costs were generally higher for patients diagnosed with later-stage disease. Net annual time costs associated with cancer were $304.3 (95% confidence interval = $257.9 to $350.9) and $279.1 (95% confidence interval = $215.1 to $343.3) for adults aged 18-64 years and ≥65 years, respectively, with higher time costs among more recently diagnosed survivors. National patient economic burden, including out-of-pocket and time costs, associated with cancer care was projected to be $21.1 billion in 2019.This comprehensive study found that the patient economic burden associated with cancer care is substantial in the United States at the national and patient levels.
Immune and inflammatory mechanisms mediate cardiovascular diseases from head to toe
Authors: Peter Libby, Ziad Mallat, Cornelia Weyand
Journal: Cardiovascular Research (2021)

Practitioners have long recognized the involvement of inflammation in certain acute cardiovascular diseases such as endocarditis, myocarditis, and pericarditis.Attention to the participation of immune and inflammatory mechanisms in chronic cardiovascular diseases has generally lagged.Yet, these pathways contribute to a broad swath of clinically important cardiovascular conditions, both acute and chronic (Figure 1).Understanding of these complex mechanisms can aid specialists in cardiovascular research and practice immeasurably by providing new concepts and illuminating novel diagnostic and therapeutic strategies.The collection of essays presented in this focused issue of Cardiovascular Research aims to promote this goal.
Longitudinal Changes in MR Elastography–based Biomarkers in Obese Patients Treated with Bariatric Surgery
Authors: Jiahui Li, Alina M. Allen, Vijay H. Shah, Armando Manduca, Richard L. Ehman, Meng Yin, Terry M. Therneau, Taofic Mounajjed, Kevin J. Glaser, Sudhakar K. Venkatesh
Journal: Clinical Gastroenterology and Hepatology (2021)
TCT-110 Fifteen-Year Trends in the Rates of Elective Percutaneous Coronary Intervention and Impact of COURAGE and ORBITA Trials: Insights From British Cardiovascular Intervention Society Dataset
Authors: Muhammad Rashid, Chris Stevens, Harindra Wijeysundera, Nick Curzen, Chee Khoo, Mohamed Mohamed, Suleman Aktaa, Peter Ludman, Mamas Mamas
Journal: Journal of the American College of Cardiology (2021)