tbuckley/cabot-search huggingface dataset:
Pleural recurrence after transthoracic needle lung biopsy in stage I lung cancer: a systematic review and individual patient-level meta-analysis
Authors: Hyunsook Hong, Seokyung Hahn, Haruhisa Matsuguma, Masayoshi Inoue, Yasushi Shintani, Osamu Honda, Yotaro Izumi, Keisuke Asakura, Hisao Asamura, Tetsuya Isaka, Kyungjong Lee, Yong Soo Choi, Young Tae Kim, Chang Min Park, Jin Mo Goo, Soon Ho Yoon
Journal: Thorax (2021)

Introduction Conflicting results exist regarding whether preoperative transthoracic biopsy increases the risk of pleural recurrence in early lung cancer. We conducted a systematic, patient-level meta-analysis to evaluate the risk of pleural recurrence in stage I lung cancer after percutaneous transthoracic lung biopsy. Methods A systematic search of OVID-MEDLINE, Embase and the Cochrane Database of Systematic Reviews was performed through October 2018. Eligible studies were original articles on the risk of pleural recurrence in stage I lung cancer after transthoracic biopsy. We contacted the corresponding authors of eligible studies to obtain individual patient-level data. We used the Fine-Gray model for time to recurrence and lung cancer-specific survival and a Cox proportional hazards model for overall survival. Results We analysed 2394 individual patient data from 6 out of 10 eligible studies. Compared with other diagnostic procedures, transthoracic biopsy was associated with a higher risk for ipsilateral pleural recurrence, which manifested solely (subdistribution HR (sHR), 2.58; 95% CI 1.15 to 5.78) and concomitantly with other metastases (sHR 1.99; 95% CI 1.14 to 3.48). In the analysis of secondary outcomes considering a significant interaction between diagnostic procedures and age groups, reductions of time to recurrence (sHR, 2.01; 95% CI 1.11 to 3.64), lung cancer-specific survival (sHR 2.53; 95% CI 1.06 to 6.05) and overall survival (HR 2.08; 95% CI 1.12 to 3.87) were observed in patients younger than 55 years, whereas such associations were not observed in other age groups. Discussion Preoperative transthoracic lung biopsy was associated with increased pleural recurrence in stage I lung cancer and reduced survival in patients younger than 55 years.
P76.59 Rationale and Design of a Phase II Trial of Dacomitinib in Advanced NSCLC Patients with Uncommon EGFR Mutations
Authors: B. Han, B. Zhang, C. Shi, Z. Gao, H. Zhong, L. Xiong, A. Gu, W. Wang, T. Chu, W. Zhang, H. Wang, X. Zhang, R. Zhong
Journal: Journal of Thoracic Oncology (2021)
American College of Rheumatology Guidance for COVID‐19 Vaccination in Patients With Rheumatic and Musculoskeletal Diseases: Version 1
Authors: Jeffrey R. Curtis, Sindhu R. Johnson, Donald D. Anthony, Reuben J. Arasaratnam, Lindsey R. Baden, Anne R. Bass, Cassandra Calabrese, Ellen M. Gravallese, Rafael Harpaz, Rebecca E. Sadun, Amy S. Turner, Eleanor Anderson Williams, Ted R. Mikuls
Journal: Arthritis & Rheumatology (2021)

To provide guidance to rheumatology providers on the use of coronavirus disease 2019 (COVID-19) vaccines for patients with rheumatic and musculoskeletal diseases (RMDs).
QIM21-083: Quantitative Evaluation of Methods Designed to Improve the Accuracy and Quality of Multi-Gene Panel Testing for Hereditary Cancer
Authors: Carolyn Horton, Holly LaDuca, Lily Hoang, Elizabeth Chao, Jill Dolinsky, Jefferey Chen, Adam Chamberlin, Rachid Karam
Journal: Journal of the National Comprehensive Cancer Network (2021)

"QIM21-083: Quantitative Evaluation of Methods Designed to Improve the Accuracy and Quality of Multi-Gene Panel Testing for Hereditary Cancer" published on 17 Mar 2021 by National Comprehensive Cancer Network.
Molecular mechanisms of osteoblastic differentiation induced by PSA in SaOS-2 osteosarcoma cells
Authors: Nagalakshmi Nadiminty, Wei Lou, Soo Ok Lee, Jason S. Kirk, Allen C. Gao
Journal: Cancer Research (2006)

1152  The high prevalence of osteoblastic bone metastases in prostate cancer involves the production of osteoblast-stimulating factors by prostate cancer cells. Prostate specific antigen (PSA) is a serine protease uniquely produced by prostate cancer cells and is an important serological marker for prostate cancer. In this study, we examined the role of PSA in the induction of osteoblast differentiation. Human cDNA containing the full coding region of PSA was stably transfected into human osteosarcoma SaOS-2 cells. SaOS-2 cells were also treated with exogenously added enzymatically active PSA. We evaluated changes in global gene expression using cDNA microarrays and northern blot analysis resulting from expression of PSA in human osteosarcoma SaOS-2 cells. The molecular mechanisms involved in mediating the effect of PSA on bone cells were examined. SaOS-2 cells expressing PSA had markedly upregulated expression of genes associated with osteoblast differentiation including runx-2 and osteocalcin compared to the controls. Consistent with these results, the stable clones expressing PSA showed increased mineralization and increased activity of alkaline phosphatase in vitro compared to controls, suggesting that these cells undergo osteoblastic differentiation. We also found that osteoprotegerin (OPG) expression was downregulated and RANKL expression upregulated in the cells expressing PSA compared to controls. Treatment of SaOS cells with exogenous enzymatically active PSA also produced similar results, suggesting that osteoblastic differentiation may be regulated by PSA. PSA-overexpressing as well as PSA-treated cells showed elevated levels of reporter activity with TGFβ-responsive luciferase, indicating that PSA may exert its effects through the activation of the TGFβ pathway. The PSA-expressing clones, which possess high levels of Wif-1, showed a reduction in TGFβ-responsive reporter activity with siRNA against Wif-1, indicating that the TGFβ and the Wnt-β-catenin pathways might participate in a cross talk and regulate the process of osteoblastic differentiation of these cells. Modulation of the expression of osteogenic genes and alteration of the balance between OPG-RANKL by PSA suggests that PSA produced by metastatic prostate cancer cells may participate in bone remodeling in favor of development of osteoblastic metastases in the heterogeneous mixture of osteolytic and osteoblastic lesions. These findings provide a molecular basis for understanding the high prevalence of osteoblastic bone metastases in prostate cancer.
Exosomal miR-125b-5p deriving from mesenchymal stem cells promotes tubular repair by suppression of p53 in ischemic acute kidney injury
Authors: Jing-Yuan Cao, Bin Wang, Tao-Tao Tang, Yi Wen, Zuo-Lin Li, Song-Tao Feng, Min Wu, Dan Liu, Di Yin, Kun-Ling Ma, Ri-Ning Tang, Qiu-Li Wu, Hui-Yao Lan, Lin-Li Lv, Bi-Cheng Liu
Journal: Theranostics (2021)

Mesenchymal stem cells-derived exosomes (MSC-exos) have attracted great interest as a cell-free therapy for acute kidney injury (AKI). However, the
Clinical and immunological effects of mRNA vaccines in malignant diseases
Authors: Annkristin Heine, Stefan Juranek, Peter Brossart
Journal: Molecular Cancer (2021)

Abstract In vitro -transcribed messenger RNA-based therapeutics represent a relatively novel and highly efficient class of drugs. Several recently published studies emphasize the potential efficacy of mRNA vaccines in treating different types of malignant and infectious diseases where conventional vaccine strategies and platforms fail to elicit protective immune responses. mRNA vaccines have lately raised high interest as potent vaccines against SARS-CoV2. Direct application of mRNA or its electroporation into dendritic cells was shown to induce polyclonal CD4+ and CD8+ mediated antigen-specific T cell responses as well as the production of protective antibodies with the ability to eliminate transformed or infected cells. More importantly, the vaccine composition may include two or more mRNAs coding for different proteins or long peptides. This enables the induction of polyclonal immune responses against a broad variety of epitopes within the encoded antigens that are presented on various MHC complexes, thus avoiding the restriction to a certain HLA molecule or possible immune escape due to antigen-loss. The development and design of mRNA therapies was recently boosted by several critical innovations including the development of technologies for the production and delivery of high quality and stable mRNA. Several technical obstacles such as stability, delivery and immunogenicity were addressed in the past and gradually solved in the recent years. This review will summarize the most recent technological developments and application of mRNA vaccines in clinical trials and discusses the results, challenges and future directions with a special focus on the induced innate and adaptive immune responses.
Clonal Evolution Mechanisms and Collateral Sensitivity to Impdh Inhibitor Therapy in Relapsed Lymphoblastic Leukemia
Authors: Chelsea Dieck, Gannie Tzoneva, Koichi Oshima, Alberto Ambesi-Impiombato, Marta Sanchez-Martin, Maria Luisa Sulis, Motohiro Kato, Katsuyoshi Koh, Maddalena Paganin, Giuseppe Basso, Julie M. Gastier-Foster, Mignon L. Loh, Renate Kirschner-Schwabe, Chioma Madubata, Raul Rabadan, Adolfo A. Ferrando
Journal: Blood (2017)
CGE21-031: Genomic Biomarker Testing, Treatments, and Survival Outcomes Among Patients With Advanced or Metastatic NSCLC in the US: A Retrospective Cohort Study
Authors: Yajun Zhu, Yimei Han, Naleen Raj Bhandari, Lisa Hess
Journal: Journal of the National Comprehensive Cancer Network (2021)

"CGE21-031: Genomic Biomarker Testing, Treatments, and Survival Outcomes Among Patients With Advanced or Metastatic NSCLC in the US: A Retrospective Cohort Study" published on 17 Mar 2021 by National Comprehensive Cancer Network.
Browning white adipose tissue using adipose stromal cell-targeted resveratrol-loaded nanoparticles for combating obesity
Authors: Yujiao Zu, Ling Zhao, Lei Hao, Yehia Mechref, Masoud Zabet-Moghaddam, Peter A. Keyel, Mehrnaz Abbasi, Dayong Wu, John A. Dawson, Ruiwen Zhang, Shufang Nie, Naima Moustaid-Moussa, Mikhail G. Kolonin, Alexes C. Daquinag, Luis Brandi, Irfan Warraich, Susan K. San Francisco, Xiaocun Sun, Zhaoyang Fan, Shu Wang
Journal: Journal of Controlled Release (2021)
P04.06 Early Surgical and Oncological Outcomes After Single Port Video Assisted Thoracoscopic Surgery Lung Resection; KHCC Experience
Authors: R. Abdeljalil, M.K.A. Chaar, O. Almajali, O. Al-Qudah, A. Al-Edwan, H. Al-Najjar, H. Ababneh, A. U’Wais
Journal: Journal of Thoracic Oncology (2021)
Efficacy of the ChAdOx1 nCoV-19 Covid-19 Vaccine against the B.1.351 Variant
Authors: Shabir A. Madhi, Vicky Baillie, Clare L. Cutland, Merryn Voysey, Anthonet L. Koen, Lee Fairlie, Sherman D. Padayachee, Keertan Dheda, Shaun L. Barnabas, Qasim E. Bhorat, Carmen Briner, Gaurav Kwatra, Khatija Ahmed, Parvinder Aley, Sutika Bhikha, Jinal N. Bhiman, As’ad E. Bhorat, Jeanine du Plessis, Aliasgar Esmail, Marisa Groenewald, Elizea Horne, Shi-Hsia Hwa, Aylin Jose, Teresa Lambe, Matt Laubscher, Mookho Malahleha, Masebole Masenya, Mduduzi Masilela, Shakeel McKenzie, Kgaogelo Molapo, Andrew Moultrie, Suzette Oelofse, Faeezah Patel, Sureshnee Pillay, Sarah Rhead, Hylton Rodel, Lindie Rossouw, Carol Taoushanis, Houriiyah Tegally, Asha Thombrayil, Samuel van Eck, Constantinos K. Wibmer, Nicholas M. Durham, Elizabeth J. Kelly, Tonya L. Villafana, Sarah Gilbert, Andrew J. Pollard, Tulio de Oliveira, Penny L. Moore, Alex Sigal, Alane Izu
Journal: New England Journal of Medicine (2021)

Assessment of the safety and efficacy of vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in different populations is essential, as is investigation of the efficacy of the vaccines against emerging SARS-CoV-2 variants of concern, including the B.1.351 (501Y.V2) variant first identified in South Africa.
P84.18 Primary Resistance to Brigatinib in a Patient with Lung Adenocarcinoma Harboring ALK G1202R Mutation and LIPI-NTRK1 Rearrangement
Authors: Z. Xiao, X. Huang, B. Xie, W. Xie, M. Huang, L. Lin
Journal: Journal of Thoracic Oncology (2021)
P35.05 The Monitoring of Mutated EGFR Levels in Liquid Biopsy from Patients on EGFR-TKIs – Early Detection of NSCLC Progression
Authors: A. Szpechcinski, M. Bryl, G. Czyzewicz, E. Wojda, M. Szwiec, D. Swiniuch, S. Rudzinski, K. Duk, R. Ramlau, P. Sliwinski, A. Barinow-Wojewodzki, J. Chorostowska-Wynimko
Journal: Journal of Thoracic Oncology (2021)
Dexamethasone plus oseltamivir versus dexamethasone in treatment-naive primary immune thrombocytopenia: a multicentre, randomised, open-label, phase 2 trial
Authors: Lu Sun, Juan Wang, Linlin Shao, Chenglu Yuan, Hongguo Zhao, Daqi Li, Zhencheng Wang, Panpan Han, Yafei Yu, Miao Xu, Hongyu Zhao, Jihua Qiu, Hai Zhou, Xinguang Liu, Yu Hou, Jun Peng, Ming Hou
Journal: The Lancet Haematology (2021)
Left cardiac sympathetic denervation in the therapy of congenital long QT syndrome. A worldwide report.
Authors: P JSchwartz, E HLocati, A JMoss, R SCrampton, RTrazzi, URuberti
Journal: Circulation (1991)

BACKGROUNDLong QT syndrome (LQTS) is a congenital disorder accompanied by a high incidence of sudden cardiac death. beta-Adrenergic blockade is the therapy of choice, and it is successful in 75-80% of patients. For those in whom cardiac events (syncope or cardiac arrest) are not prevented by beta-blockade, experimental studies suggest that left cardiac sympathetic denervation (LCSD) may be useful.METHODS AND RESULTSWe identified 85 LQTS patients worldwide who underwent LCSD, and we provide here the first large-scale evaluation of its efficacy. The time interval between the first cardiac event and LCSD and the follow-up period after LCSD were similar (5.6 +/- 6.1 versus 5.9 +/- 5.7 years). The mean age of the patients at surgery was 20 +/- 13 years. LCSD was followed by highly significant (p less than 0.0001) decreases in the number of patients with cardiac events (from 99% to 45%), in the number of cardiac events per patient (from 22 +/- 32 to 1 +/- 3), and in the number of patients with five or more card...
Mechanisms of vasoconstriction induced by 9,11-epithio-11,12-methano-thromboxane A2 in the rabbit coronary artery.
Authors: YKanmura, TItoh, HKuriyama
Journal: Circulation Research (1987)

The vasoconstrictor effects of 9,11-epithio-11,12-methano-thromboxane A2 (STA2) on smooth muscle strips of the rabbit coronary artery have been investigated in vitro. Right coronary artery (RCA) was more responsive to STA2 than either the left anterior descending or the circumflex coronary artery. On endothelium-denuded RCA strips, the sensitivity and responsiveness to STA2 were greater than observed on intact muscle strips. A thromboxane(Tx)-antagonist, (9,11), (11,12)-dideoxa-9 alpha, 11 alpha-dimethylmethano-11,12-methano-13,14-dihydro-13-aza-14-oxo-15 - cyclopenthyl-16,17,18,19,20-pethanol-15-epi-TxA2 (ONO-3708), inhibited the STA2-induced contraction, whereas atropine or prazosin had no effect. Nifedipine partly inhibited the STA2-induced contraction, one half of which was still evoked in Ca2+-free solution. When acetylcholine was applied prior to the application of STA2 in Ca2+-free solution, the STA2-vasoconstriction disappeared. In saponin-treated chemically skinned muscle strips, STA2 itself had ...
The influence of constitutional variables on orthogonal electrocardiograms of normal women.
Authors: MNemati, DMcCaughan, J TDoyle, H VPipberger
Journal: Circulation (1977)

Correlations between 276 orthogonal electrocardiographic measurements and constitutional variables were made in 450 normal women, aged 18 to 90 years. Advancing age led to decreases in amplitudes, left QRS axis shift, rightward and superior displacement of the ST segment, and anterior shift of the T wave. QZ was absent in 1% of normal women over age 40. In the oldest subjects, Ry amplitude was 71% and RZ amplitude was 80% of the respective values in the youngest group. Whereas QRS amplitude decreases with age leveled off at the sixth decade of life, they continued to old age for ST-T measurements. Men revealed steeper age trends than women. Blacks had larger QRS amplitudes and smaller Q/R ratios than whites. Stratification of electrocardiographic criteria according to age, sex, and race appears essential for routine interpretations and for epidemiological studies where new events, such as myocardial infarcts, need to be differentiated from normal age trends.
Underwater Endoscopic Papillectomy
Authors: D Rodriguez, A Jesús
Journal: Endoscopy (2021)

Endoscopic examination reveals a benign-looking lesion in the papillary region. Technique: We proceed to instill abundant intraluminal fluid. This measure facilitates the lesion protrudes into the duodenal lumen, which practically floats on the liquid intraluminal, easily fit inside the loop. The lesion is cut and extracted.
A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes.
Authors: C HLuo, YRudy
Journal: Circulation Research (1994)

A mathematical model of the cardiac ventricular action potential is presented. In our previous work, the membrane Na+ current and K+ currents were formulated. The present article focuses on processes that regulate intracellular Ca2+ and depend on its concentration. The model presented here for the mammalian ventricular action potential is based mostly on the guinea pig ventricular cell. However, it provides the framework for modeling other types of ventricular cells with appropriate modifications made to account for species differences. The following processes are formulated: Ca2+ current through the L-type channel (ICa), the Na(+)-Ca2+ exchanger, Ca2+ release and uptake by the sarcoplasmic reticulum (SR), buffering of Ca2+ in the SR and in the myoplasm, a Ca2+ pump in the sarcolemma, the Na(+)-K+ pump, and a nonspecific Ca(2+)-activated membrane current. Activation of ICa is an order of magnitude faster than in previous models. Inactivation of ICa depends on both the membrane voltage and [Ca2+]i. SR is d...
Reduction in experimental infarct size by recombinant human superoxide dismutase: insights into the pathophysiology of reperfusion injury.
Authors: GAmbrosio, L CBecker, G MHutchins, H FWeisman, M LWeisfeldt
Journal: Circulation (1986)

To determine the importance of reperfusion injury and the ability of the free-radical scavenger recombinant human superoxide dismutase (h-SOD) to prevent it, open-chest dogs underwent 90 min of proximal circumflex coronary artery occlusion, and only at the moment of reperfusion received either h-SOD (400,000 IU bolus into the left atrium followed by a 300,000 IU iv infusion over 1 hr) or saline. After 48 hr the surviving animals were killed and measurements were made of the risk region (by postmortem angiography) and infarct size (by gross pathology). All measurements were made by investigators blinded to treatment given, and the code was broken only at the end of the study. Hemodynamic variables and collateral flow during ischemia were similar in the two groups. Infarct size in control animals (n = 8) averaged 22.4 +/- 3.1% of the left ventricle and 52.2 +/- 7.1% of the risk region, compared with 13.3 +/- 0.8% of the left ventricle and 33.6 +/- 2.1% of the risk region in h-SOD-treated dogs (n = 8) (p les...
IFNγ Is Critical for CAR T Cell–Mediated Myeloid Activation and Induction of Endogenous Immunity
Authors: Darya Alizadeh, Robyn A. Wong, Sharareh Gholamin, Madeleine Maker, Maryam Aftabizadeh, Xin Yang, Joseph R. Pecoraro, John D. Jeppson, Dongrui Wang, Brenda Aguilar, Renate Starr, Claire B. Larmonier, Nicolas Larmonier, Min-Hsuan Chen, Xiwei Wu, Antoni Ribas, Behnam Badie, Stephen J. Forman, Christine E. Brown
Journal: Cancer Discovery (2021)

Abstract Chimeric antigen receptor (CAR) T cells mediate potent antigen-specific antitumor activity; however, their indirect effects on the endogenous immune system are not well characterized. Remarkably, we demonstrate that CAR T-cell treatment of mouse syngeneic glioblastoma (GBM) activates intratumoral myeloid cells and induces endogenous T-cell memory responses coupled with feed-forward propagation of CAR T-cell responses. IFNγ production by CAR T cells and IFNγ responsiveness of host immune cells are critical for tumor immune landscape remodeling to promote a more activated and less suppressive tumor microenvironment. The clinical relevance of these observations is supported by studies showing that human IL13Rα2–CAR T cells activate patient-derived endogenous T cells and monocytes/macrophages through IFNγ signaling and induce the generation of tumor-specific T-cell responses in a responding patient with GBM. These studies establish that CAR T-cell therapy has the potential to shape the tumor microenvironment, creating a context permissible for eliciting endogenous antitumor immunity. Significance: Our findings highlight the critical role of IFNγ signaling for a productive CAR T-cell therapy in GBM. We establish that CAR T cells can activate resident myeloid populations and promote endogenous T-cell immunity, emphasizing the importance of host innate and adaptive immunity for CAR T-cell therapy of solid tumors. This article is highlighted in the In This Issue feature, p. 2113
Euthanasia for Minors in Belgium
Authors: Judith A. C. Rietjens, Lenzo Robijn, Agnes van der Heide
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Detection of Breast Cancer
Authors: Robert J. Glaser
Journal: JAMA (1978)

To the Editor.—  In the letter entitled Detection of Breast Cancer (238:1247, 1977) from Jerome Urban, MD, it seems to me that the course of action outlined in the last sentence is not logical. It is suggested that in a patient with suspicious clinical findings and a normal mammogram, the latter ought to be disregarded and biopsy performed. Why subject the patient to a mammogram at all? In the presence of suspicious clinical findings, why not move immediately to the biopsy? If the mammogram is positive, one would certainly do the biopsy, and as indicated by Dr Urban, if the mammogram were negative, one would likewise do the biopsy. It seems to me that one of our problems in medicine these days is that we overuse technology, and a mammogram in a patient such as Dr Urban describes seems to fall in that category.