tbuckley/cabot-search huggingface dataset:
Clinical significance and hemodynamic correlates of the third heart sound gallop in aortic regurgitation. A guide to optimal timing of cardiac catheterization.
Authors: A MAbdulla, M JFrank, R AErdin, M ICanedo
Journal: Circulation (1981)

The hemodynamic and clinical data of 42 patients with chronic significant aortic regurgitation and 31 normal subjects were examined. Of the patients with aortic regurgitation, 28 had a third heart sound (S3) gallop and 14 did not. There was no significant difference in the severity of regurgitation between the patients with or without an S3 gallop. However, all patients with an S3 gallop had an abnormality increased left ventricular residual volume and depressed contractile state. These findings were supported by the hemodynamic data of two patients who underwent cardiac catheterization before and after the development of an S3 gallop. We conclude that the S3 gallop in patients with chronic AR reflects left ventricular dysfunction, rather than more severe degrees of regurgitation per se, and may therefore be useful for selecting patients for cardiac catheterization and consideration for prosthetic aortic valve replacement.
特異な転移がみられた原発性肝癌 切除後,肝門部リンパ節再発病巣から門脈腫よう塞栓を来した肝細胞癌の1例
Authors: 塙勝博, 森川賢一, 小西一男, 西田均, 荒瀬強, 亀山真一朗, 加藤博久, 草野満夫, 三田村圭二
Journal: Liver Cancer (2001)
Epigenetic age acceleration changes 2 years after antiretroviral therapy initiation in adults with HIV: a substudy of the NEAT001/ANRS143 randomised trial
Authors: Andrés Esteban-Cantos, Javier Rodríguez-Centeno, Pilar Barruz, Belén Alejos, Gabriel Saiz-Medrano, Julián Nevado, Artur Martin, Francisco Gayá, Rosa De Miguel, Jose I Bernardino, Rocío Montejano, Beatriz Mena-Garay, Julen Cadiñanos, Eric Florence, Fiona Mulcahy, Denes Banhegyi, Andrea Antinori, Anton Pozniak, Cédrick Wallet, François Raffi, Berta Rodés, Jose R Arribas
Journal: The Lancet HIV (2021)
Heterogeneity of myosin isozyme content of rabbit heart.
Authors: R ZLitten, B JMartin, R HBuchthal, RNagai, R BLow, N RAlpert
Journal: Circulation Research (1985)

A detailed study was carried out to measure the relative contents of V1 and V3 myosin isozymes in different regions of rabbit ventricle as a function of age, to assess animal-to-animal variability, and to compare different experimental approaches aimed at minimizing the effects of such variability. In addition, comparisons were made in normal developing hearts between ventricular isozyme composition and myofibrillar myosin calcium-stimulated adenosine triphosphatase. V1 isozyme predominated relative to V3 isozyme in the hearts of 2-week-old rabbits, decreasing to become a minor component in 10-week-old animals. Despite this trend, there was considerable variability in relative isozyme content of whole ventricular tissue among different rabbits of the same age. This variability was reduced in comparisons of littermates and by use of cardiac biopsies to measure changes in isozyme content in the same animal over time. Within different regions of a given heart, there also were small but significant difference...
Shall The Journal be Removed to Washington?
Authors: W. F, Rochelle
Journal: JAMA (1891)

<h3>To the Editor:</h3> —From a common-sense view of the subject, it does appear that a petty rivalry plays a prominent part in the controversy. If there is one cause more patent than all others whyThe Journalshould be moved, it perhaps lies in this query: Is it more profitable to cater to the whims of one faction rather than observe the old adage, " let well enough alone? " Whilst it is probable thatThe Journalwould receive an additional support, both in contributors and readers, if moved, yet this gain would most likely be at the expense of losing some of the present support. But for a solution of this problem, much of course depends on a proper appreciation of the rivalry existing between the two sections, and the bearing of this rivalry on the medical profession. A medical journal in any section of the country, receives most of the
Coronary microvascular responses to reductions in perfusion pressure. Evidence for persistent arteriolar vasomotor tone during coronary hypoperfusion.
Authors: W MChilian, S MLayne
Journal: Circulation Research (1990)

The goals of this study were to test the following hypotheses: 1) Coronary autoregulatory adjustments to decreases in perfusion pressure occur primarily in coronary arterioles (less than 150 microns in diameter). 2) Small coronary arteries (greater than 150 microns in diameter) can be recruited to participate in the autoregulatory adjustments as perfusion pressure is progressively lowered. 3) Small arterioles are the location of vasodilator reserve in the coronary microcirculation during hypoperfusion. Studies were performed in anesthetized open-chest dogs in which coronary perfusion pressures were reduced to 80, 60, 40, and 30 mm Hg. During reductions in coronary perfusion pressure, measurements were made of systemic hemodynamics, myocardial blood flow (radioactive microspheres), and coronary microvascular diameters. Arterial pressure and heart rate were largely unchanged during the experimental maneuvers. Measurements of microvascular diameters in the beating heart were performed during epi-illumination...
Abstract 20164: Profiling of Circulating MicroRNAs After Heart Transplantation and During Acute Cellular and Antibody-Mediated Rejection
Authors: RaymondGivens, DanielleTempleton, RuipingJi, PeterKennel, DonnaMancini, YoshifumiNaka, HirooTakayama, IsaacGeorge, P. CSchulze
Journal: Circulation (2014)

Introduction: Heart transplantation (HTx) is the definitive treatment for advanced heart failure. Despite universal immunosuppressive therapy, the threat of allograft rejection is persistent. Rejection is generally diagnosed by histology of graft myocardium obtained by biopsy which is invasive and prone to sampling error. Study of novel biomarkers such as circulating microRNAs (miRs) may allow noninvasive diagnosis of rejection. Methods: We studied serum levels of miRs associated with immune cell function (miR-155, 125b, 142-3p, 144, 223-3p, 27a and 101), myocardial damage (miR-1) and immunosuppression (let-7a). Blood was obtained from HTx recipients >2 months post-HTx. Rejection was defined by histology of cardiac biopsy specimens and graded according to ISHLT guidelines. MiRs were analyzed with RT-PCR and normalized to 5S rRNA. Results: We analyzed samples from 12 healthy volunteers (44±6 yrs), 12 HTx recipients without evidence of rejection (54±11 yrs), 11 patients with acute cellular rejection (ACR; 4...
Victims of Crime
Authors: Neill F. David
Journal: JAMA (1976)

<h3>To the Editor.—</h3> Rodstein's article, "Crime and the Aged: 1. The Victims" (234:533-534, 1975), proposes "remedies" for the protection of older persons from assault or other crimes. At no point does the author consider the need for societal changes suggested by an editorial in the same issue ofThe Journal(234:521, 1975). Perhaps Rodstein believed such changes impossible of achievement.
AIDS and human rights
Authors: R. Voelker
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neutrophil function in ischemic heart disease.
Authors: JMehta, JDinerman, PMehta, T GSaldeen, DLawson, W HDonnelly, RWallin
Journal: Circulation (1989)

Neutrophils contribute to the healing of and scar formation in myocardium after ischemic injury. Many recent studies indicate that neutrophils may be involved in the genesis and propagation of myocardial ischemia. To characterize neutrophil function in ischemic heart disease, neutrophil chemotaxis, leukotriene B4 (LTB4) generation, and elastase release in plasma were measured in 20 patients with stable angina, 17 patients with unstable angina or acute myocardial infarction (AMI), and 20 age-matched control subjects. Neutrophils from patients with stable angina exhibited markedly increased chemotactic activity and LTB4 generation as compared with the age-matched control subjects (p less than 0.01). Neutrophils of nine of 17 patients with unstable angina or AMI clumped spontaneously ex vivo and exhibited marked pseudopod formation and granule extrusion on electron microscopy. Subsequent chemotactic activity and LTB4 generation by neutrophils from these patients was less than in patients with stable angina, ...
Trends in survival of hospitalized myocardial infarction patients between 1970 and 1985. The Minnesota Heart Survey.
Authors: P GMcGovern, A RFolsom, J MSprafka, G LBurke, K MDoliszny, JDemirovic, J DNaylor, HBlackburn
Journal: Circulation (1992)

BACKGROUNDThe Minnesota Heart Survey is a population-based study designed to monitor and explain trends in cardiovascular mortality, morbidity, and risk factors. As part of this effort, a 50% sample of patients hospitalized for myocardial infarction (MI) in the seven-county Twin Cities (Minneapolis and St. Paul) metropolitan area was reviewed in 1970, 1980, and 1985. Those with a validated definite MI were followed for 4-year mortality. The purpose was to determine whether the improved survival observed between 1970 and 1980 was extended to the 1980-1985 period.METHODS AND RESULTSCrude 28-day mortality in men changed from 18% in 1970 to 12% in 1980 to 13% in 1985; in women it changed from 27% in 1970 to 22% in 1980 to 18% in 1985. After adjustment for severity factors (e.g., age, previous MI, and admission heart rate and systolic blood pressure), 28-day mortality was significantly lower in 1980 than in 1970 in men (RR, 0.66; 95% CI, 0.47, 0.92) and in women (RR, 0.69; 95% CI, 0.46, 1.04), but no change oc...
Effects of lung inflation on blood flow during cardiopulmonary resuscitation in the canine isolated heart-lung preparation.
Authors: M JHausknecht, R AWise, R GBrower, CHassapoyannes, M LWeisfeldt, JSuzuki, SPermutt
Journal: Circulation Research (1986)

Using an isolated, fibrillated canine heart-lung preparation, we studied the effects of simultaneous lung inflation and chest compression on blood flow in a model of cardiopulmonary resuscitation. The heart and lungs were placed in an artificial thorax with the great vessels and trachea exteriorized and attached to an artificial perfusion circuit and respirator, respectively. The blood volume of the system was adjusted to obtain various levels of static equilibrium pressure. Blood flow was obtained by cyclically raising and lowering the pressure in the artificial thorax, simulating the changes in pleural pressure that occur during cardiopulmonary resuscitation. Lung inflation during the compression phase caused an increase in cardiopulmonary resuscitation blood flow when the change in pleural pressure was small and when static equilibrium pressure was high. In contrast, lung inflation caused a decrease in blood flow when changes in pleural pressure were high and when blood volume was low. These results su...
Deaths certified as due to coronary artery disease.
Journal: BMJ (1991)

SIR,-Dr K R Sumner suggests that examination ofthe brain is not included in the coroner's necropsy in his area and that some deaths are therefore wrongly attributed to coronary artery disease.I can assure him that this is not standard practice.In most places, including my own department, full examination of the brain is routinely performed in both coroners' and hospital necropsies.In some cases the brain may even be suspended in formalin and examined after fixation.Only in exceptional circumstances-for example, a hospital necropsy for which permission to open the head is refused - would this practice be altered.Pathologists, more than anyone, recognise the limitations of a necropsy in establishing cause of death.Often it may be more appropriate simply to record the gross abnormalities present, accepting that the role of cardiac arrhythmias, metabolic disorders, etc, may be impossible to establish.This is particularly so if procedures such as full dissection and histological examination of the cardiac conducting system, not feasible as a routine in district general hospitals' pathology departments, are not performed.The coroner, however, will require the pathologist to give a cause of death at the end of the necropsy.Failure to do
Macrophage inhibitory cytokine‐1 induced by a high‐fat diet promotes prostate cancer progression by stimulating tumor‐promoting cytokine production from tumor stromal cells
Authors: Mingguo Huang, Shintaro Narita, Atsushi Koizumi, Taketoshi Nara, Kazuyuki Numakura, Shigeru Satoh, Hiroshi Nanjo, Tomonori Habuchi
Journal: Cancer Communications (2021)

Abstract Background Recent studies have indicated that a high‐fat diet (HFD) and/or HFD‐induced obesity may influence prostate cancer (PCa) progression, but the role of HFD in PCa microenvironment is unclear. This study aimed to delineate the molecular mechanisms of PCa progression under HFD milieus and define the stromal microenvironment focusing on macrophage inhibitory cytokine‐1 (MIC‐1) activation. Methods We investigated the effects of HFD on PCa stromal microenvironment and MIC‐1 signaling activation using PC‐3M‐luc‐C6 PCa model mice fed with HFD or control diet. Further, we explored the effect of periprostatic adipocytes derived from primary PCa patients on activation and cytokine secretion of prostate stromal fibroblasts. Expression patterns and roles of MIC‐1 signaling on human PCa stroma activation and progression were also investigated. Results HFD stimulated PCa cell growth and invasion as a result of upregulated MIC‐1 signaling and subsequently increased the secretion of interleukin (IL)‐8 and IL‐6 from prostate stromal fibroblasts in PC‐3M‐luc‐C6 PCa mouse model. In addition, periprostatic adipocytes directly stimulated MIC‐1 production from PC‐3 cells and IL‐8 secretion in prostate stromal fibroblasts through the upregulation of adipose lipolysis and free fatty acid release. The increased serum MIC‐1 was significantly correlated with human PCa stroma activation, high serum IL‐8, IL‐6, and lipase activity, advanced PCa progression, and high body mass index of the patients. Glial‐derived neurotrophic factor receptor α‐like (GFRAL), a specific receptor of MIC‐1, was highly expressed in both cytoplasm and membrane of PCa cells and surrounding stromal fibroblasts, and the expression level was decreased by androgen deprivation therapy and chemotherapy. Conclusion HFD‐mediated activation of the PCa stromal microenvironment through metabolically upregulated MIC‐1 signaling by increased available free fatty acids may be a critical mechanism of HFD and/or obesity‐induced PCa progression.
Re: Guido Giusti, Silvia Proietti, Moises E. Rodríguez-Socarrás, et al. Simultaneous Bilateral Endoscopic Surgery (SBES) for Patients with Bilateral Upper Tract Urolithiasis: Technique and Outcomes. Eur Urol 2018;74:810–5
Authors: Jie Gu, Dongjie Li, Xiaobo Zhang
Journal: European Urology (2018)
Angiotensin II induces fibronectin expression associated with cardiac fibrosis in the rat.
Authors: D CCrawford, A VChobanian, PBrecher
Journal: Circulation Research (1994)

Fibronectin expression was studied in the heart of rats given a continuous infusion of angiotensin II (Ang II). Northern blot analysis showed that left ventricular fibronectin steady-state mRNA increased fivefold to eightfold in response to pressor doses of Ang II after 24 hours. Accumulation of immunodetectable fibronectin in the ventricles occurred after the mRNA levels increased. The changes in fibronectin expression were reversible when Ang II treatment was withdrawn. The Ang II-induced increase in fibronectin mRNA accompanied similar increases for collagen type I, collagen type IV, and atrial natriuretic factor steady-state mRNA. Interstitial and perivascular fibrosis was identified in both ventricles of angiotensin-treated rats within 3 days. In situ hybridization identified cells associated with areas of fibrosis as the principal site of fibronectin mRNA accumulation in treated animals. By comparison, normal hearts showed fibronectin expression primarily within ventricular vascular tissue and the a...
A method for measuring the rate of oxygen release from single microvessels.
Authors: NTateishi, NMaeda, TShiga
Journal: Circulation Research (1992)

A system determining the rate of oxygen release from erythrocytes flowing in single microvessels was constructed with an inverted microscope by connecting 1) a scanning/grating spectrophotometer equipped with a photon-counting detector through a thin light guide, to obtain the visible absorption spectrum of a spot (5 microns in diameter) focused on a microvessel, 2) two photomultipliers (connected to a microcomputer via an analog-to-digital converter) through two light guides, to determine the flow velocity of erythrocytes by calculating the cross correlation between the light-intensity changes of two spots (3 microns in diameter, 5 microns apart from each other) focused on the microvessel, and 3) an image processor through a video camera, to estimate the diameter of microvessel from the digitized video images. The rate of oxygen release from single microvessels 7-25 microns in diameter in rat mesentery was measured under the superfusion of deoxygenated solution: 1) The maximal rate was obtained in capill...
A fatal trip with ecstasy: a case of 3,4-methylenedioxymethamphetamine/3,4- methylenedioxyamphetamine toxicity.
Authors: Coore
Journal: Journal of the Royal Society of Medicine (1996)

Abstract
Since the late 1980s there have been a number of reports about the complications associated with using the designer drug 3,4-methylenedioxymethamphetamine (MDMA) or 'ecstasy'. Although this drug has been widely abused in the past, the potentially fatal complications have arisen recently mainly due to the circumstances of its use at all-night dance sessions or 'raves'. A combination of direct toxicity and strenuous physical exertion can lead to hyperthermia and its attendant complications. The following case illustrates some of the possible consequences following ingestion of 'ecstasy', and reiterates the importance of prompt recognition and treatment in preventing the development of irreversible sequelae.
Endoscopic Pemr Resection Large Duodenum Neoplasms, Effective And Safe Method Endoscopic Treatment Patients With Large Duodenum Lesion
Authors: K Aleksandr, S Andrii, D Aleksandr, K Aleksandr, S Andrii, D Aleksandr, B Dmitriy
Journal: Endoscopy (2021)

Aims Patients with large duodenum neoplasms can be operated on surgically with a high risk of complications and mortality. Endoscopic piece EMR resection large duodenum lesions are effective and safe method endoscopic treatment. An increasing number of nonampullary duodenal neoplasm (NADM) made possible by increasing screening gastroduodenoscopy and used higher definition endoscopy with magnification and NBI examination.
Analysis of creatine kinase, CK-MB, myoglobin, and troponin T time-activity curves for early assessment of coronary artery reperfusion after intravenous thrombolysis.
Authors: MZabel, S HHohnloser, WKöster, MPrinz, WKasper, HJust
Journal: Circulation (1993)

BACKGROUNDThrombolysis has become the standard therapeutic approach in patients with acute myocardial infarction. To identify patients who may benefit from early invasive procedures, reliable noninvasive assessment of success or failure of thrombolytic therapy is mandatory.METHODS AND RESULTSIn a prospective study in 63 consecutive patients undergoing thrombolysis for their first myocardial infarction, serial measurements of creatine kinase (CK), its isoenzyme CK-MB, myoglobin, and troponin T were done to determine their value for noninvasive prediction of coronary artery patency. Blood samples were drawn every 15 minutes during the first 90 minutes, every 30 minutes during the first 4 hours, every 4 hours during the first 24 hours, and every 8 hours during the first 72 hours. The perfusion status of the infarct-related artery was assessed angiographically 90 minutes after initiation of thrombolysis. For each marker, time to its peak concentration and its early initial slope (start of thrombolysis to 90 m...
Pulmonary vascular responses to forebrain stimulation in the cat.
Authors: A LHyman, C WDempesy, CFontana, D ERichardson, R WRieck, P JKadowitz
Journal: Circulation Research (1988)

The effects of forebrain stimulation on the pulmonary vascular bed were investigated in the intact-chest cat under conditions of controlled blood flow and constant left atrial pressure. When pulmonary vascular tone was raised to a high steady level, direct electrical stimulation of the forebrain elicited a biphasic change in lobar arterial pressure. The response was characterized by an initial transient increase in lobar arterial pressure that was followed by a prolonged secondary decrease in pressure. When a delay coil was added to the extracorporeal perfusion circuit, the secondary vasodilator response was separated into initial brief and delayed prolonged components, suggesting that it was mediated in part by the release of a humoral factor. The entire response to forebrain stimulation was abolished by cervical cord section or freezing. The initial constrictor response and early brief dilator response were not blocked by classic pharmacological blocking agents. The delayed humorally mediated vasodilato...
Cardiac sarcoplasmic reticulum chloride channels regulated by protein kinase A.
Authors: SKawano, FNakamura, TTanaka, MHiraoka
Journal: Circulation Research (1992)

In heart cells, several plasma membrane ion channels are targets for phosphorylation. However, it is not known whether sarcoplasmic reticulum (SR) ion channels, which are also essential in the regulation of cardiac function, are regulated by second-messenger systems. Here, we show that a Cl- channel in the cardiac SR membrane is activated by the catalytic subunit of protein kinase A (PKA). Purified cardiac heavy SR vesicles were incorporated into planar lipid bilayers. This channel spontaneously inactivated within a few minutes after the channel was incorporated into the bilayer. Mg-ATP (2-5 mM), but not the nonhydrolyzable ATP analogue 5'-adenylylimidodiphosphate, added to the cis solution prevented this spontaneous channel inactivation. After the inactivation process occurred, the catalytic subunit of PKA (with 0.05 mM Mg-ATP) reactivated this channel. These effects of Mg-ATP and PKA on the Cl- channel were prevented by an inhibitor of PKA. Thus, these results suggest that this SR Cl- channel is a novel...
TCT-69 Transcatheter Aortic Heart Valves: Histological Analysis Providing Insight to Leaflet Thickening and Structural Valve Degeneration
Authors: Stephanie Sellers, Christropher Turner, Tim Cartlidge, Janarthanan Sathananthan, Frances Sin, Rihab Bouchareb, John Mooney, Bjarne Norgaard, Jeroen Bax, Pascal Bernatchez, Marc Dweck, David Granville, David Newby, Sandra Lauck, John Webb, Geoffrey Payne, Philippe Pibarot, Philipp Blanke, Michael Seidman, Jonathon Leipsic
Journal: Journal of the American College of Cardiology (2018)