tbuckley/cabot-search huggingface dataset:
Safety and immunogenicity of the SARS-CoV-2 BNT162b1 mRNA vaccine in younger and older Chinese adults: a randomized, placebo-controlled, double-blind phase 1 study
Authors: Jingxin Li, Aimin Hui, Xiang Zhang, Yumei Yang, Rong Tang, Huayue Ye, Ruiru Ji, Mei Lin, Zhongkui Zhu, Özlem Türeci, Eleni Lagkadinou, Siyue Jia, Hongxing Pan, Fuzhong Peng, Zhilong Ma, Zhenggang Wu, Xiling Guo, Yunfeng Shi, Alexander Muik, Uğur Şahin, Li Zhu, Fengcai Zhu
Journal: Nature Medicine (2021)
Abstract 13698: Relationship Between the Carotid Atherosclerotic Burden Score and Stroke in the Postoperative of Myocardial Revascularization Surgery and/or Aortic Valve Replacement
Authors: Diego M Lowenstein Haber, Francisco Martin Perea, Mariano Pipkin, Gustavo Giunta, Fabian Salmo, Gerardo Bozovich, Enrique Gurfinkel, Eduardo Guevara, Jorge M Cors
Journal: Circulation (2010)

Background: Prior studies have shown an association between atherosclerotic burden and vascular events, as well as the relationship among severe carotid obstruction and stroke, in patients undergoi...
An Ultra‐Stable, Oxygen‐Supply Nanoprobe Emitting in Near‐Infrared‐II Window to Guide and Enhance Radiotherapy by Promoting Anti‐Tumor Immunity
Authors: Meng Wang, Hao Li, Biao Huang, Song Chen, Ran Cui, Zhi‐Jun Sun, Mingxi Zhang, Taolei Sun
Journal: Advanced Healthcare Materials (2021)

Abstract Currently, radiotherapy (RT) is the main method for cancer treatment. However, the hypoxic environment of solid tumors is likely to cause resistance or failure of RT. Moreover, high‐dose radiation may cause side effects to surrounding normal tissues. In this study, a new type of nanozyme is developed by doping Mn (II) ions into Ag 2 Se quantum dots (QDs) emitting in the second near‐infrared window (NIR‐II, 1000–1700 nm). Through the catalysis of Mn (II) ions, the nanozymes can trigger the rapid decomposition of H 2 O 2 and produce O 2 . Conjugated with tumor‐targeting arginine‐glycine‐aspartate (RGD) tripeptides and polyethylene glycol (PEG) molecules, the nanozymes are then constructed into in vivo nanoprobes for NIR‐II imaging‐guided RT of tumors. Owing to the radiosensitive activity of the element Ag, the nanoprobes can promote radiation energy deposition. The specific tumor‐targeting and NIR‐II emitting abilities of the nanoprobes facilitate the precise tumor localization, which enables precise RT with low side effects. Moreover, their ultra‐stability in the living body ensures that the nanoprobes continuously produce oxygen and relieve the hypoxia of tumors to enhance RT efficacy. Guided by real‐time and high‐clarity imaging, the nanoprobe‐mediated RT promotes anti‐tumor immunity, which significantly inhibits the growth of tumors or even cures them completely.
It is Women &amp; Sports at #sportfisio2021
Authors: Mario Bizzini, Nicolas Mathieu
Journal: British Journal of Sports Medicine (2021)

The Swiss Sports Physiotherapy Association (SSPA) will hold-hopefully-its 19th annual conference on 19 November 2021 in Bern, capital of Switzerland and home of this event since 2005 (figure 1).The goal of SSPA has always been to organise a high-quality scientific congress featuring international high-profile speakers.We invite you to relive all our conferences (since 2013) on our YouTube channel (https:// www.youtube.com/ channel/
Pro-Tmune, the Next Generation Graft for Allogeneic Hematopoietic Cell Transplantation: Phase 1 Safety and Efficacy Data
Authors: Richard Maziarz, John Edwards, James Essell, Cesar Freytes, Chatchada Karanes, Ayman Saad, Dimitrios Tzachanis, Monica Diaz, Amanda Medcalf, Daniel Fremgen, Chris Storgard, Abhinav Deol
Journal: Blood (2017)
Whole-genome resequencing of 445 Lactuca accessions reveals the domestication history of cultivated lettuce
Authors: Tong Wei, Rob van Treuren, Xinjiang Liu, Zhaowu Zhang, Jiongjiong Chen, Yang Liu, Shanshan Dong, Peinan Sun, Ting Yang, Tianming Lan, Xiaogang Wang, Zhouquan Xiong, Yaqiong Liu, Jinpu Wei, Haorong Lu, Shengping Han, Jason C. Chen, Xuemei Ni, Jian Wang, Huanming Yang, Xun Xu, Hanhui Kuang, Theo van Hintum, Xin Liu, Huan Liu
Journal: Nature Genetics (2021)
Abstract 17088: In-Hospital Complications and Outcomes of Leadless Pacemaker Implantation: A Propensity-Score Matched Analysis From Nationwide Database
Authors: Moghniuddin Mohammed, Amit Noheria, Seth Sheldon, Madhu Reddy
Journal: Circulation (2020)

Introduction: There are no randomized controlled trials that compared the outcomes of leadless pacemaker (L-PPM) implantation with transvenous pacemaker (TV-PPM) and there is scarcity of data on real world outcomes. Methods: We queried National Inpatient Sample to identify all adult patients who had primary discharge diagnosis of conduction disorders or tachy-arrhythmias and excluded patients who had a concomitant procedure for valve replacement, coronary artery bypass grafting, ablation and/or cardiac implantable electronic device removal so that complications can be attributed to the pacemaker implantation. We included only procedures from November 2016 to December 2017 as Micra was the only available L-PPM during that period. For the comparison cohort we selected patients, during the same time period, who had a procedure code for single chamber pacemaker implantation in conjunction with right ventricular lead placement. We performed 1:1 propensity score matching and the variables used for matching are marked with asterisk in Table 1. All the codes used to identify complications has been previously validated from the Micra Post-approval registry and Coverage with Evidence Study. Results: Total of 1,305 patients for L-PPM and 13,905 patients in the TV-PPM group were included. Baseline characteristics with standardized mean difference before and after matching are shown in Table 1. Briefly, patients in L-PPM group were younger but had higher co-morbidities compared to TV-PPM group. The complications before and after matching are shown in Table 2. Conclusions: In conclusion, we found no significant difference between in-hospital complications after propensity score matching, with the exception of deep venous thrombosis. There was no difference between length of stay but cost for L-PPM was significantly higher. In this real-world analysis, we found that the leadless PPM implantation is safe in comparison to transvenous PPM.
Prostate-Specific Membrane Antigen Expression in Patients With Differentiated Thyroid Cancer With Thyroglobulin Elevation and Negative Iodine Scintigraphy Using 68Ga-PSMA-HBED-CC PET/CT
Authors: Priyanka Verma, Gaurav Malhotra, Vilas Meshram, Ashok Chandak, Sunita Sonavane, Anurag R. Lila, Tushar R. Bandgar, Ramesh V. Asopa
Journal: Clinical Nuclear Medicine (2021)

Purpose of the Report Prostate-specific membrane antigen (PSMA) is a member of superfamily of zinc-dependent exopeptidases that is robustly expressed in prostate cancer cells and nonprostatic solid tumor neovasculature including microvessels of thyroid tumors. Its expression in differentiated thyroid cancer (DTC) has been confirmed in many recent studies, but systematic studies exploring PSMA expression in patients with DTC with thyroglobulin elevation and negative iodine scintigraphy (TENIS) are lacking. The aim of the present study was to evaluate the role of PSMA scan in TENIS patients with DTC. Methods Nine consecutive patients with DTC with proven TENIS syndrome (6 men and 3 women with age range 29–68 years and mean age of 48 years) underwent 18 F-FDG PET/CT as per the institution protocol. Thereafter, they were subjected to 68 Ga-PSMA-HBED-CC PET/CT as per the institution protocol within a week of FDG PET imaging. Prostate-specific membrane antigen expression (SUVmax) in the lesions was compared with 18 F-FDG PET and CT scan findings. Results In 5 of 9 patients with TENIS, the metastatic lesions showed PSMA expression. A total of 14 lesions were seen on the CT scan. Prostate-specific membrane antigen PET detected 9 of 14 lesions (64.28%) (SUVmax ranging from 10.1 to 45.67; median SUVmax of 16.31), whereas FDG PET was positive in 11 of 14 lesions (78.57%). The lesions that showed PSMA uptake was localized to bones (5 of 9) and lungs (4 of 9). Two lesions that were localized to iliac crest and acetabulum were missed on FDG PET but were seen on CT and PSMA PET scan. Conclusions The results of this pilot study indicate that 68 Ga-HBED-CC-PSMA PET/CT demonstrates PSMA expression in TENIS patients with lesions being localized to the bones and lungs. 68 Ga-PSMA PET/CT could be useful for the identification of TENIS patients who might benefit from PSMA-targeted radionuclide therapy.
Oxygenated End-Hypothermic Machine Perfusion in Expanded Criteria Donor Kidney Transplant
Authors: Peri Husen, Catherine Boffa, Ina Jochmans, Christina Krikke, Lucy Davies, Laura Mazilescu, Aukje Brat, Simon Knight, Daniel Wettstein, Orsolya Cseprekal, Neal Banga, Maria Irene Bellini, Laszlo Szabo, Elijah Ablorsu, Tom Darius, Isabel Quiroga, Michel Mourad, Johann Pratschke, Vassilios Papalois, Zoltan Mathe, Henri G. D. Leuvenink, Thomas Minor, Jacques Pirenne, Rutger J. Ploeg, Andreas Paul
Journal: JAMA Surgery (2021)

<h3>Importance</h3> Continuous hypothermic machine perfusion during organ preservation has a beneficial effect on graft function and survival in kidney transplant when compared with static cold storage (SCS). <h3>Objective</h3> To compare the effect of short-term oxygenated hypothermic machine perfusion preservation (end-HMPo<sub>2</sub>) after SCS vs SCS alone on 1-year graft survival in expanded criteria donor kidneys from donors who are brain dead. <h3>Design, Setting, and Participants</h3> In a prospective, randomized, multicenter trial, kidneys from expanded criteria donors were randomized to either SCS alone or SCS followed by end-HMPo<sub>2</sub>prior to implantation with a minimum machine perfusion time of 120 minutes. Kidneys were randomized between January 2015 and May 2018, and analysis began May 2019. Analysis was intention to treat. <h3>Interventions</h3> On randomization and before implantation, deceased donor kidneys were either kept on SCS or placed on HMPo<sub>2</sub>. <h3>Main Outcome and Measures</h3> Primary end point was 1-year graft survival, with delayed graft function, primary nonfunction, acute rejection, estimated glomerular filtration rate, and patient survival as secondary end points. <h3>Results</h3> Centers in 5 European countries randomized 305 kidneys (median [range] donor age, 64 [50-84] years), of which 262 kidneys (127 [48.5%] in the end-HMPo<sub>2</sub>group vs 135 [51.5%] in the SCS group) were successfully transplanted. Median (range) cold ischemia time was 13.2 (5.1-28.7) hours in the end-HMPo<sub>2</sub>group and 12.9 (4-29.2) hours in the SCS group; median (range) duration in the end-HMPo<sub>2</sub>group was 4.7 (0.8-17.1) hours. One-year graft survival was 92.1% (n = 117) in the end-HMPo<sub>2</sub>group vs 93.3% (n = 126) in the SCS group (95% CI, −7.5 to 5.1;<i>P</i> = .71). The secondary end point analysis showed no significant between-group differences for delayed graft function, primary nonfunction, estimated glomerular filtration rate, and acute rejection. <h3>Conclusions and Relevance</h3> Reconditioning of expanded criteria donor kidneys from donors who are brain dead using end-HMPo<sub>2</sub>after SCS does not improve graft survival or function compared with SCS alone. This study is underpowered owing to the high overall graft survival rate, limiting interpretation. <h3>Trial Registration</h3> isrctn.org Identifier:ISRCTN63852508
The Impact of Stuttering—Hiding in Plain Sight
Authors: Patrick M. Briley, Charles Ellis, Molly M. Jacobs
Journal: JAMA Neurology (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Hyperventilation/Breath-Hold Maneuver to Detect Myocardial Ischemia by Strain-Encoded CMR
Authors: Marco M Ochs, Isabelle Kajzar, Janek Salatzki, Andreas T Ochs, Johannes Riffel, Nael Osman, Hugo A Katus, Matthias G Friedrich
Journal: JACC. Cardiovascular imaging (2021)
人工知能支援システムは結腸直腸新生物の内視鏡同定を改善する【JST・京大機械翻訳】
Authors: Kudo Shin-ei, Misawa Masashi, Mori Yuichi, Hotta Kinichi, Ohtsuka Kazuo, Ikematsu Hiroaki, Saito Yutaka, Takeda Kenichi, Nakamura Hiroki, Ichimasa Katsuro, Ishigaki Tomoyuki, Toyoshima Naoya, Kudo Toyoki, Hayashi Takemasa, Wakamura Kunihiko, Baba Toshiyuki, Ishida Fumio, Inoue Haruhiro, Itoh Hayato, Oda Masahiro, Mori Kensaku
Journal: Clinical Gastroenterology and Hepatology (2020)
Could NAD+ Precursor Supplements Induce a Legacy of Protection against Diabetic Nephropathy?
Authors: Kelly A. Hyndman, Matthew D. Griffin
Journal: Journal of the American Society of Nephrology (2021)

Diabetic nephropathy (DN) is a complex disease with microvascular complications, profound changes in metabolism, inflammation, and redox status, leading to structural and functional changes that can culminate in ESKD. Early DN is defined by glomerular hyperfiltration and albuminuria, and
The role of Autotaxin in glioblastoma multiforme invasion.
Authors: Dominique B. Hoelzinger, Christian Beaudry, Tim Demuth, Luigi Mariani, Mitsutoshi Nakada, Michael E. Berens
Journal: Cancer Research (2005)

251  One of the salient features of malignant astrocytomas is the propensity to diffusely invade brain parenchyma; it is from these invading cells that the tumor invariably recurs. A better understanding of the molecular mechanisms of this locally invasive behavior could yield potential therapeutic targets aimed exclusively at this tumor cell sub-population. To this end, a gene expression profile of GBM invasion was created by comparing mRNA from invasive cells to that of matched non-invasive cells from the tumor core. Differences in expression patterns between the two laser capture microdissected cell populations revealed multiple genes related to invasion. Amongst these was the autocrine motility factor Autotaxin (ATX, also known as ectonucleotide pyrophosphatase/ phosphodiesterase 2, ENPP2), which was first described in invasive melanoma. ATX has also been reported in metastatic breast carcinoma, neuroblastoma and several others carcinomas. Recently its role as a lysophospholipase D was identified, catalyzing lysophosphatidyl choline (LPC) into the bioactive lipid lysophosphatidic acid (LPA). LPA stimulates motility in various cell types, including glioma cells, which express high levels of LPA1 receptor. Evaluation of ATX expression in a glioma specific tissue microarray revealed a high expression in the invading cells of astrocytic tumors of all grades. To investigate the functional role of ATX in astrocytoma invasion stable transfectants carrying wild type ATX and a catalytically inactive form (H316Q-U251), were created using the U251 glioma cell line. ATX-U251 migrated significantly faster than H316Q-U251 in a radial migration assay, an effect that was not reversed by LPA dependent motility stimulation. Cells expressing high levels of ATX also proved more adherent to laminin specifically in the presence of its substrate LPC. To test the property of invasion we used an orthotopic rat brain slice assay, which showed ATX-U251 to be more highly invasive than H316Q-U251 or control cells. ATX knockdown with siRNA resulted in lowered invasion of spheroids in a collagen I matrix, an effect that was reversed with the addition of LPA. Changes in motility that are induced by LPA receptors result in cytoskeltal rearrangements brought about by the rho family of GTPases. We examined cytoskeletal changes in the poorly motile H316Q-U251 cells and found normal stress fibers, enhanced filopodia formation and severely reduced membrane ruffles, suggesting modulation of rac signaling. Further studies consist of elucidating whether the motility inhibition of the secreted protein H316QATX functions in a paracrine or autocrine manner. Supported by NIH NS-42262
Effect of Early Recombinant Human Erythropoietin on Neurodevelopmental Outcomes at Age 5 Years—Reply
Authors: Giancarlo Natalucci, Hans Ulrich Bucher, Jean-Claude Fauchère
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Discussion of DNACPR processes in medical education would improve practice
Authors: Angelica Sharma, Arun Sharma
Journal: BMJ (2021)

Do not attempt cardiopulmonary resuscitation (DNACPR) decisions are a vital component of medical care.1 General Medical Council guidelines state that doctors have a duty to consult patients regarding this decision unless such discussion is thought to cause physical or psychological harm.2

Consultants and seniors hold responsibility for overseeing discussions and documentation. It’s usually junior doctors—including foundation year 1s (FY1s)—who …
Abstract 12517: Endothelial Cell Specific Hspa12b Alters Resident and Infiltrated Macrophages in the Myocardium Following Myocardial Infarction
Authors: Yana Wang, Spencer P Gill, Fei Tu, Xiaohui Wang, Jingjing Xu, Min Fan, Kun Yang, Tuanzhu Ha, Li Liu, John Kalbfleisch, David Williams, Chuanfu Li
Journal: Circulation (2018)

Introduction: HSPA12B is a newly discovered member of HSP70 family and plays a role in angiogenesis. Increased expression of endothelial HSPA12B preserved cardiac function following myocardial infa...
An integrated approach to COVID-19 follow up in stockport;our experience so far
Authors: D. Tanase, K. McEwan, R. Wiggans, N. Alkemade, M. Gregory, C. Betts, A. Newey, H. Sunderland, S. Gaduzo, M. Childs, F. Gardiner, B. Currer, L. Gifford, T. Curtis, P. Hood, V. Gupta
Journal: Gut (2021)

Background/Aims The long-term physical and psychological impact on patients admitted with Covid-19 is unknown  NHSE1 and BTS2 released guidance on aftercare of these patients  In Stockport, a Covid-19 recovery group was established to optimise pathways and ensure seamless, joined up care for patients on discharge  Methods The group included consultants (respiratory, ICU, geriatrician), GPs, CCG leads, LMC members, a psychologist, fatigue specialists, OTs/physiotherapists, the PR/COPD team and Life leisure  A Covid recovery and fatigue management Patient Information Leaflet (PIL) were designed supporting self-care with signposting to local services  Patients were triaged2 and all received letters explaining their follow up and a Covid recovery PIL  The pathway ensured all patients had a planned telephone consultation with their GP or respiratory consultant at 6 weeks  If admitted to critical care, they received an ICU clinic and clinical psychologist review at 12 weeks  Secondary care Covid-19 clinics were established to see patients according to BTS guidance, with slots available for urgent GP referrals  Patients were signposted to appropriate specialties/services (fatigue, psychology, physiotherapy, SALT) and a dedicated EMIS Covid review template in primary care was designed;the template facilitated standardised coding, improving understanding of longer-term effects of Covid-19  An online webinar was organised launching the pathway and highlighting available resources  Activity packs were provided for frailer patients, both individual patients and those in care homes supporting rehabilitation and preventing readmission  Patients were referred to PR if appropriate and one off fatigue management appointments were available  Results To date around 350 patients have been sent letters/ PILs  29 have been seen/telephoned in Covid-19 Clinics and 26 in ICU clinics  Initial patient feedback has been extremely positive, with 92% patients finding the PIL very/extremely useful and feeling the leaflet provided everything they needed to know about Covid-19 recovery  83% patients were completely happy with the care they received post discharge and didn't feel it could be improved  Conclusion We have developed a novel, multi-disciplinary and integrated approach to following up Covid-19 patients  Whilst many long-term effects remain unknown, the pathway allows patients to rapidly access services when needed  Feedback has been extremely positive from patients to date
Identification of a novel subset of alveolar type 2 cells enriched in PD-L1 and expanded following pneumonectomy
Authors: Negah Ahmadvand, Farhad Khosravi, Arun Lingampally, Roxana Wasnick, Ana Ivonne Vazquez-Armendariz, Gianni Carraro, Monika Heiner, Stefano Rivetti, Yuqing Lv, Jochen Wilhelm, Andreas Gunther, Susanne Herold, Denise Al Alam, Chengshui Chen, Parviz Minoo, Jin-San Zhang, Saverio Bellusci
Journal: European Respiratory Journal (2021)

Alveolar type 2 (AT2) cells are heterogeneous cells, with specialised AT2 subpopulations within this lineage exhibiting stem cell properties. However, the existence of quiescent, immature cells within the AT2 lineage that are activated during lung regeneration is unknown.
Comprehensive Analysis of CMV pp65 Antigen-Specific CD8+ T Cell Responses According to HLA Class I Alleles and Intra-Individual Dominance
Authors: Seung-Joo Hyun, Hyun-Jung Sohn, Hyun-Joo Lee, Seon-Duk Lee, Dea-Hee Sohn, Sueon Kim, Cheol-Hwa Hong, Haeyoun Choi, Hyun-Il Cho, Il-Hoan Oh, Tai-Gyu Kim
Journal: Blood (2017)
Can Biomarkers Guide Oncolytic Virus Immunotherapy?
Authors: Howard L. Kaufman
Journal: Clinical Cancer Research (2021)

Abstract Defects in tumor cell IFNγ signaling is associated with resistance to immune checkpoint inhibitors. Recently, these defects were found to confer increased sensitivity to oncolytic virus infection. Differential expression of innate sensing elements in tumor cells may serve as predictive biomarkers of oncolytic virus immunotherapy in patients with cancer. See related article by Nguyen et al., p. 3432