tbuckley/cabot-search huggingface dataset:
Human Germline HLTF E259K Mutation Identified in Familial MDS Patients Accumulates DNA Damage through Impaired PCNA Polyubiquitination
Authors: Kensuke Takaoka, Masahito Kawazu, Junji Koya, Akihide Yoshimi, Yosuke Masamoto, Hiroaki Maki, Takashi Toya, Takashi Kobayashi, Yasuhito Nannya, Shunya Arai, Hironori Ueno, Kenshi Suzuki, Hironori Harada, Atsushi Manabe, Yasuhide Hayashi, Hiroyuki Mano, Mineo Kurokawa
Journal: Blood (2017)
The Therapeutic Response of Chidamide Was Associated with Elevated H3 Acetylation Level in Patients with Refractory/Relapsed Non-Hodgkin Lymphoma (R/R-NHL)
Authors: Hui-qiang Huang, Pengfei Li, Yan Gao, Bai Bing, Wang Xiaoxiao, Rong Qixiang, Su Li, Wenqi Jiang
Journal: Blood (2017)
Abstract 340: Effect of the 2015 CPR Guidelines for Patients With Out-Of-Hospital Cardiac Arrest Due to Non-Shockable Rhythm: Results From the All-Japan Utstein Registry
Authors: Tsukasa Yagi, Ken Nagao, Eizo Tachibana, Naohiro Yonemoto, Yoshio Tahara, Hiroshi Nonogi, Takanori Ikeda, Naoki Sato, Hiroyuki Tsutsui
Journal: Circulation (2019)

Background: The 2015 cardiopulmonary resuscitation (CPR) guidelines have stressed that high-quality CPR improves survival from cardiac arrest (CA). In particular, the guidelines recommended that it is reasonable for rescuers to perform chest compressions at a rate of 100 to 120/min in adult CA patients. However, it is unknown whether the 2015 guidelines contributed to favorable neurological outcome in adult CA patients. The present study aimed to clarify the effects of the 2015 guidelines in adult CA patients, using the data of the All-Japan Utstein Registry, a prospective, nationwide, population-based registry of out-of-hospital CA (OHCA). Methods: From the data of this registry between 2011 and 2016, we included adult witnessed OHCA patients due to cardiac etiology, who had non-shockable rhythm, PEA and asystole, as an initial rhythm. Study patients were divided into two groups based on the different CPR guidelines; the era of the 2010 guidelines (2010G), and the era of the 2015 guidelines (2015G). The endpoint was the favorable neurological outcome at 30 days after OHCA. Results: The 109,175 patients who met the inclusion criteria comprised 18,764 who received CPR based on 2015G and 90,411 who received CPR based on 2010G. The figure showed favorable neurological outcomes at 30 days in the two groups. In the multivariate analysis, the adjusted odds ratio for 30-day favorable neurological outcome in 2015G patients as compared to 2010G patients was 1.28 (95%CI 1.11-1.46, p&lt;0.001). Conclusion: In the OHCA patients with non-shockable rhythm, the 2015 guidelines were superior to the 2010 guidelines, in terms of neurological benefits.
Abstract 285: Analysis of Neurological Prognosis After Cardiac Arrest Patients by Using Cerebral Regional Oxygen Saturation Monitoring
Authors: Jotaro Tachino, Tadahiko Shiozaki, Ryosuke Takegawa, Tomohiko Sakai, Shunichiro Nakao, Mitsuo Ohnishi, Takeshi Shimazu
Journal: Circulation (2019)

Objective: To clarify the neurological prognosis of post-resuscitation hypoxic encephalopathy patients on the basis of cerebral autoregulation. Methods: We conducted a prospective, observational cohort study of patients admitted to our urban emergency and critical care center in Japan between 2017 and 2019. Cerebral regional oxygen saturation (rSO 2 ) was measured in patients with cardiopulmonary arrest on hospital arrival or return of spontaneous circulation (ROSC) before hospital arrival. Included in the analysis were patients aged ≥16 years who were transported to our hospital. Patients dying within 24 h of hospitalization were excluded. Immediately after arrival, the cerebral rSO 2 sensor was attached to the patient’s forehead and continuous monitoring was started. Continuous monitoring of cerebral rSO 2 and mean arterial pressure (MAP) was conducted until extubation or 96 hours after ROSC. We divided the patients into the good neurological prognosis group (cerebral performance category: CPC 1, 2) and poor neurological prognosis group (CPC 3-5) and compared them. Results: Among the 37 patients with a mean age (± SD) of 68.9 (± 14.8) years, 12 had a good neurological prognosis and 25 had a poor neurological prognosis. In the good neurological cases, we found that the cerebral rSO 2 value showed biphasic changes followed by a long plateau around the lower limit of the normal rSO 2 range from 12 h after ROSC. However, in the poor neurological prognosis cases, we observed that the cerebral rSO 2 value was unstable. In addition, our data showed that the cerebral rSO 2 values in the good neurological prognosis cases remained almost constant even if MAP changed (Figure). Conclusions: We observed the transition of cerebral rSO 2 and its characteristics after resuscitation in cases with good neurological prognosis. Focusing on the cerebral autoregulation may be useful to predict neurological prognosis in post-resuscitation hypoxic encephalopathy.
Quantification of adverse skin reactions secondary to mask wearing using 3-dimensional imaging technology: A prospective cohort study
Authors: Rachel Elsanadi, Fiore Casale, Katerina Yale, Cristina Nguyen, Niki Nourmohammadi, Vardit Eckhouse, Yoav Cohen, Natasha Atanaskova Mesinkovska
Journal: Journal of the American Academy of Dermatology (2021)
Early Change in Epithelial Neutrophilic Infiltrate Predicts Long-Term Response to Biologics in Ulcerative Colitis
Authors: Neeraj Narula, Emily C.L. Wong, Jean-Frederic Colombel, Robert Riddell, John K. Marshall, Walter Reinisch, Parambir S. Dulai
Journal: Clinical Gastroenterology and Hepatology (2021)
Abstract 301: Identifying Critical Care Unit Organizational Factors That Impact Cardiac Arrest Incidence and Outcomes: A Report From the Pediatric Cardiac Critical Care Consortium
Authors: Javier J Lasa, Jeffrey A Alten, Mousumi Banerjee, Wenying Zhang, Kurt Schumacher, Michael G Gaies
Journal: Circulation (2019)

Introduction: Patient factors leading to cardiac arrest (CA) in the pediatric cardiac critical care unit (CICU) are well understood, but may be unmodifiable. Our understanding of the impact of CICU organizational factors (OFs) such as staffing models, health care provider education, and CICU bed management is limited. The association between these potentially modifiable CICU OFs on CA prevention and rescue outcomes is unknown. Hypothesis: CICU OFs associate with CA prevention and rescue. Methods: Retrospective analysis of Pediatric Cardiac Critical Care Consortium (PC4) clinical registry including data for all patients admitted to CICUs from August 2014 to March 2019. Prevention was defined as the prevalence of subjects not suffering CA. Rescue was defined as survival after CA. CICU OFs were captured via questionnaire distributed to PC4 participants in 2017 (100% response). Stratified, multivariable regression was used to evaluate associations between OFs and outcome in medical and surgical admission subgroups: competing time-to-events framework (to assess prevention) and multinomial regression (to assess rescue), accounting for clustering of patients within hospitals. Results: We analyzed 54,521 CICU admissions (59% surgical, 41% medical) from 29 hospitals with 1398 CA events (2.5%). We studied 12 OFs that varied across centers after accounting for collinearity. For both surgical and medical admissions, lower average daily occupancy (&lt;80%) was associated with better arrest prevention for all admissions, and better rescue in the surgical cohort. Increased proportion of nurses with &gt;2 years experience, increased proportion of nurses with critical care certification, % of full-time intensivists, % of intensivists with critical care training, dedicated respiratory therapists, quality/safety resources, and annual CICU admission volume were not associated with improved prevention or rescue. Conclusion: Our multi-institutional analysis suggests that lower average CICU occupancy was the only consistent OF evaluated that was associated with CA prevention and rescue. CICUs that have average daily occupancy &gt;80% may need specific strategies to mitigate the risks of CA.
Prognostic factors for adverse outcomes in patients with COVID-19: a field-wide systematic review and meta-analysis
Authors: Vanesa Bellou, Ioanna Tzoulaki, Maarten van Smeden, Karel G.M. Moons, Evangelos Evangelou, Lazaros Belbasis
Journal: European Respiratory Journal (2021)

Introduction The individual prognostic factors for coronavirus disease 2019 (COVID-19) are unclear. For this reason, we aimed to present a state-of-the-art systematic review and meta-analysis on the prognostic factors for adverse outcomes in COVID-19 patients. Methods We systematically reviewed PubMed from 1 January 2020 to 26 July 2020 to identify non-overlapping studies examining the association of any prognostic factor with any adverse outcome in patients with COVID-19. Random-effects meta-analysis was performed, and between-study heterogeneity was quantified using I 2 statistic. Presence of small-study effects was assessed by applying the Egger's regression test. Results We identified 428 eligible articles, which were used in a total of 263 meta-analyses examining the association of 91 unique prognostic factors with 11 outcomes. Angiotensin-converting enzyme inhibitors, obstructive sleep apnoea, pharyngalgia, history of venous thromboembolism, sex, coronary heart disease, cancer, chronic liver disease, COPD, dementia, any immunosuppressive medication, peripheral arterial disease, rheumatological disease and smoking were associated with at least one outcome and had &gt;1000 events, p&lt;0.005, I 2 &lt;50%, 95% prediction interval excluding the null value, and absence of small-study effects in the respective meta-analysis. The risk of bias assessment using the Quality in Prognosis Studies tool indicated high risk of bias in 302 out of 428 articles for study participation, 389 articles for adjustment for other prognostic factors and 396 articles for statistical analysis and reporting. Conclusions Our findings could be used for prognostic model building and guide patient selection for randomised clinical trials.
Levothyroxine Use in the United States, 2008-2018
Authors: Juan P. Brito, Joseph S. Ross, Omar M. El Kawkgi, Spyridoula Maraka, Yihong Deng, Nilay D. Shah, Kasia J. Lipska
Journal: JAMA Internal Medicine (2021)

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The association between SARS-CoV-2 RT-PCR cycle threshold and mortality in a community cohort
Authors: Rupert Waudby-West, Benjamin J. Parcell, Colin N.A. Palmer, Samira Bell, James D. Chalmers, Moneeza K. Siddiqui
Journal: European Respiratory Journal (2021)

<b>Ct values from RT-PCR tests are associated with risk of mortality in SARS-CoV-2 infection. Hazards of Ct values &lt;20 compared to &gt;30 were 2.20 (95% CI 1.28–3.76) in a model adjusted for age, sex, comorbidities and hospitalisation.</b>https://bit.ly/3gjuqdU
Comment on Ferrannini and Rosenstock. Clinical Translation of Cardiovascular Outcome Trials in Type 2 Diabetes: Is There More or Is There Less Than Meets the Eye? Diabetes Care 2021;44:641–646
Authors: Stavros Liatis
Journal: Diabetes Care (2021)

I read with great interest the recent Perspective by Ferrannini and Rosenstock (1), which provides thoughtful insight on the interpretation of the numerous recent cardiovascular outcome trials (CVOT) in the field of type 2 diabetes.

As far as I understand, though, there are some numerical mistakes in both Table 1 and Fig. 2 A and B that may seriously affect the overall understanding of the article. Specifically, in Table 1, although the incidence rates (IRs) of all the reported outcomes are expressed per 1,000 patient years (py), the corresponding values derived from the Liraglutide Effect and Action in Diabetes: Evaluation of …
Consolidative Radiation with Chemotherapy in Early Stage Classical Hodgkin Lymphoma with Unfavorable Risk: The Kentucky Experience
Authors: Zin W Myint, Runa Shrestha, Jaclyn Nee, Bin Huang, Eric Durbin, Stacey Slone, Amit Goldberg, Maryam Zia, Reshma Ramlal, Gregory Monohan, Roger H. Herzig, Roger A. Fleischman, Gerhard Carl Hildebrandt, Hayder Saeed
Journal: Blood (2017)
PRAISE: providing a roadmap for automated infection surveillance in Europe
Authors: Maaike S.M. van Mourik, Stephanie M. van Rooden, Mohamed Abbas, Olov Aspevall, Pascal Astagneau, Marc J.M. Bonten, Elena Carrara, Aina Gomila-Grange, Sabine C. de Greeff, Sophie Gubbels, Wendy Harrison, Hilary Humphreys, Anders Johansson, Mayke B.G. Koek, Brian Kristensen, Alain Lepape, Jean-Christophe Lucet, Siddharth Mookerjee, Pontus Naucler, Zaira R. Palacios-Baena, Elisabeth Presterl, Miquel Pujol, Jacqui Reilly, Christopher Roberts, Evelina Tacconelli, Daniel Teixeira, Thomas Tängdén, John Karlsson Valik, Michael Behnke, Petra Gastmeier
Journal: Clinical Microbiology and Infection (2021)

Healthcare-associated infections (HAI) are among the most common adverse events of medical care. Surveillance of HAI is a key component of successful infection prevention programmes. Conventional surveillance - manual chart review - is resource intensive and limited by concerns regarding interrater reliability. This has led to the development and use of automated surveillance (AS). Many AS systems are the product of in-house development efforts and heterogeneous in their design and methods. With this roadmap, the PRAISE network aims to provide guidance on how to move AS from the research setting to large-scale implementation, and how to ensure the delivery of surveillance data that are uniform and useful for improvement of quality of care.The PRAISE network brings together 30 experts from ten European countries. This roadmap is based on the outcome of two workshops, teleconference meetings and review by an independent panel of international experts.This roadmap focuses on the surveillance of HAI within networks of healthcare facilities for the purpose of comparison, prevention and quality improvement initiatives. The roadmap does the following: discusses the selection of surveillance targets, different organizational and methodologic approaches and their advantages, disadvantages and risks; defines key performance requirements of AS systems and suggestions for their design; provides guidance on successful implementation and maintenance; and discusses areas of future research and training requirements for the infection prevention and related disciplines. The roadmap is supported by accompanying documents regarding the governance and information technology aspects of implementing AS.Large-scale implementation of AS requires guidance and coordination within and across surveillance networks. Transitions to large-scale AS entail redevelopment of surveillance methods and their interpretation, intensive dialogue with stakeholders and the investment of considerable resources. This roadmap can be used to guide future steps towards implementation, including designing solutions for AS and practical guidance checklists.
Vaccinating undocumented migrants against covid-19
Authors: Yot Teerawattananon, Yik Ying Teo, Jeremy Fung Yen Lim, Li Yang Hsu, Saudamini Dabak
Journal: BMJ (2021)

The world is starting to glimpse a possible end to the covid-19 pandemic, thanks to the international rollout of vaccines against SARS-CoV-2.But as these vaccines are delivered around the globe, some groups are being left out, putting everyone in harm's way.Undocumented migrants, including migrant workers, refugees, and other displaced people, are one such group.
The Epidemiology of Microscopic Colitis in Olmsted County, Minnesota: Population-Based Study From 2011 to 2019
Authors: June Tome, Kanika Sehgal, Amrit K Kamboj, William S Harmsen, Patricia P Kammer, Edward V Loftus, William J Tremaine, Sahil Khanna, Darrell S Pardi
Journal: Clinical Gastroenterology and Hepatology (2021)
Single-cell atlas of tumor cell evolution in response to therapy in hepatocellular carcinoma and intrahepatic cholangiocarcinoma
Authors: Lichun Ma, Limin Wang, Subreen A. Khatib, Ching-Wen Chang, Sophia Heinrich, Dana A. Dominguez, Marshonna Forgues, Julián Candia, Maria O. Hernandez, Michael Kelly, Yongmei Zhao, Bao Tran, Jonathan M. Hernandez, Jeremy L. Davis, David E. Kleiner, Bradford J. Wood, Tim F. Greten, Xin Wei Wang
Journal: Journal of Hepatology (2021)
VP6-2021: IMpassion050: A phase III study of neoadjuvant atezolizumab + pertuzumab + trastuzumab + chemotherapy (neoadj A + PH + CT) in high-risk, HER2-positive early breast cancer (EBC)
Authors: J. Huober, C.H. Barrios, N. Niikura, M. Jarzab, Y-C. Chang, S.L. Huggins-Puhalla, V. Graupner, D. Eiger, V. Henschel, N. Gochitashvili, C. Lambertini, E. Restuccia, H. Zhang
Journal: Annals of Oncology (2021)
Abstract 392: Decreased ARNT Mediates Cardiovascular Endothelial Dysfunction in Diabetic Cardiomyopathy
Authors: Maura Knapp, Mei Zheng, Hao Huang, James K Liao, Rongxue Wu
Journal: Circulation Research (2016)

Background: Endothelial dysfunction is thought to be one of the key risk factors leading to cardiac dysfunction. We have previously shown that ARNT is a critical regulator of cardiac metabolism and its deletion in the heart mimics diabetic cardiomyopathy. Here, we hypothesize that reduced ARNT expression in the endothelium may lead to endothelial dysfunction and contribute to diabetic cardiomyopathy. Methods and Results: Primary cardiac endothelial cells (mCVEC) were isolated from DB/DB mouse hearts and confirmed using vWF staining and flow cytometry. Isolated mCVEC from DB/DB mice showed more than a 50% reduction in ARNT protein levels, suggesting that endothelial ARNT may play a role in diabetic hearts. We generated a mouse with an endothelial specific ARNT deletion (ecARNT -/- ) by crossing ARNT flox/flox mice with Cre recombinase mice under the control of the VE-Cadherin promoter. Deletion of ARNT in the endothelium was achieved by the administration of oral tamoxifen chow. ecARNT -/- mice displayed cardiac hypertrophy and worsened cardiac function after high-fat chow feeding. In vitro studies were done using siRNA technology to knockdown ARNT in mCVEC. Knockdown of ARNT did not increase cell viability at base level, but led to impaired capillary-like endothelial tube formation and reduced cell migration in response to high glucose treatment. Nitric oxide (NO) production (a marker of endothelial dysfunction) and eNOS expression were also reduced after ARNT knockdown. To determine the underlying mechanisms by which ARNT may regulate endothelial metabolism we performed a DNA microarray and confirmed our results using RT-PCR. We discovered a significant induction of NF-kB and its target genes, including ELAM-1 and ICAM-1. These changes are similar to those we observed in mCVEC from DB/DB mouse hearts. Taken together, this data shows that a reduction in ARNT may regulate endothelial dysfunction in the diabetic heart through an inflammatory pathway. Conclusion: Endothelial ARNT may be a critical mediator of endothelial function and could serve as a therapeutic target for diabetic cardiomyopathy.
Identifying acute exacerbations of chronic obstructive pulmonary disease using patient-reported symptoms and cough feature analysis
Authors: Scott Claxton, Paul Porter, Joanna Brisbane, Natasha Bear, Javan Wood, Vesa Peltonen, Phillip Della, Claire Smith, Udantha Abeyratne
Journal: npj Digital Medicine (2021)

Abstract Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are commonly encountered in the primary care setting, though the accurate and timely diagnosis is problematic. Using technology like that employed in speech recognition technology, we developed a smartphone-based algorithm for rapid and accurate diagnosis of AECOPD. The algorithm incorporates patient-reported features (age, fever, and new cough), audio data from five coughs and can be deployed by novice users. We compared the accuracy of the algorithm to expert clinical assessment. In patients with known COPD, the algorithm correctly identified the presence of AECOPD in 82.6% (95% CI: 72.9–89.9%) of subjects ( n = 86). The absence of AECOPD was correctly identified in 91.0% (95% CI: 82.4–96.3%) of individuals ( n = 78). The diagnostic agreement was maintained in milder cases of AECOPD (PPA: 79.2%, 95% CI: 68.0–87.8%), who typically comprise the cohort presenting to primary care. The algorithm may aid early identification of AECOPD and be incorporated in patient self-management plans.
Low-Level SAMHD1 Expression in Acute Myeloid Leukemia Blasts Correlates with Favorable Outcome in Patients with Diploid Cytogenetics Treated with Cytarabine-Based Chemotherapy Regimens
Authors: George Rassidakis, Herold Nikolas, Ida Hed Hed Myrberg, Nikolaos Tsesmetzis, Dan Grander, Hagop M. Kantarjian, L. Jeffrey Medeiros, Ioanna Xagoraris, Joseph David Khoury
Journal: Blood (2017)
Abstract 49: A Proposed Role for Transmembrane Activator and Cyclophilin Ligand Interactor (TACI) in Cardiovascular Disease: Adaptive Immunity and Atherosclerosis
Authors: Omar A Meelu
Journal: Circulation Research (2016)

Objective: To elucidate a proposed role of TACI, a tumor necrosis factor (TNF) family member of human B cells, in atherosclerosis. Whereas atherosclerosis has been characterized by inflammation, adaptive immunity, and specifically the role of B cells and their respective cytokine processes have not, and thus we focused on the role of a B cell homeostasis regulator, TACI. We chose TACI because it has been shown, in combination with immunoglobulins, to inhibit cells involved in the innate response, known to be the initial responders to atherosclerosis. Approach and Results: As there are two isoforms of TACI in mice, we needed to first confirm whether human B cells had one or two isoforms, before understanding preferential expression. To this end, we examined peripheral blood mononuclear cells (PBMCs), multiple myeloma cell lines and Hodgkin’s disease cells and found that both the longer and the shorter isoform of TACI are expressed. We did this by: stimulation of cell lines with IL-6, western blot analysis and densitometry, polymerase chain reaction. Student’s t-test, with the use of Statistical Analysis System (Cray, NC), for statistical analysis. Conclusion: Thus, based on our findings of the existence of both isoforms, functional analyses in cardiomyocytes would shed light on any proposed role of TACI in the context if coronary artery disease.