Effect of Slower vs Faster Intravenous Fluid Bolus Rates on Mortality in Critically Ill Patients
Authors: Fernando G. Zampieri, Flávia R. Machado, Rodrigo S. Biondi, Flávio G. R. Freitas, Viviane C. Veiga, Rodrigo C. Figueiredo, Wilson J. Lovato, Cristina P. Amêndola, Murillo S. C. Assunção, Ary Serpa-Neto, Jorge L. R. Paranhos, José Andrade, Michele M. G. Godoy, Edson Romano, Felipe Dal Pizzol, Emerson B. Silva, Miqueias M. L. Silva, Miriam C. V. Machado, Luiz Marcelo S. Malbouisson, Airton L. O. Manoel, Marlus M. Thompson, Lanese M. Figueiredo, Rafael M. Soares, Tamiris A. Miranda, Lucas M. de Lima, Eliana V. Santucci,, Thiago D. Corrêa, Luciano C. P. Azevedo, John A. Kellum, Lucas P. Damiani, Nilton B. Silva, Alexandre B. Cavalcanti, Rodrigo Biondi, Bruno C. R. Amaral, Edvar Ferreira R., Andrea Z. Abdalla, Flávio G. R. de Freitas, Nathaly F. Nunes, Rodrigo C. da Cunha, Elijane F. Alves, Rodrigo C. Figueiredo, Rodrigo B. Bortolini, Cintia L. Sartori, Eduardo S. Marques, Maria A de Sousa, Danieri Y. V. Tomotani, Airton L. O. Manoel, Wilson J. Lovato, Bruno G. Dantas, Leonardo C. Palma, Fábio L. da Silva, Cristina P. Amendola, Luciana C. Sanches, Fernanda A. M. Scuoteguazza, Ligia Z. de Britto, Ary Serpa, Niklas S. Campos, Fabio B. Hohmann, Guilherme B. Olivato, Jorge L.R. Paranhos, Iany G. da Silva, Adilson de C. Meireles, Viviane C. Veiga, Juliana C. Coelho, Maiko M. Silveira, Agnes C. Lisboa, Marco A.V. Guedes, Luiz C.S. Passos, Daniela C. Dorta, Ramana A. Rangel, Péricles Duarte, Eraldo de A. Lúcio, Eduardo B. Tondo, Pablo A.A. Vaz, Paula K. de Oliveira, Lúcio C. de Oliveira, Paulo H.P. Ferreira, Patrick H.S. Sampaio, Maurício G.S. Serra, Thiago C. Lisboa, Caroline Fachini, André P. Torelly, Alldren Souza, Fábio H. Lacerda, Eliana V. N. Martins, Bruno A.M.P. Besen, Carlos E. Brandão, João M. Silva, Flávio W.F. Melo, Flávio A. dos Santos, Israel S. Maia, Cássio L. Zandonai, Eduardo Berbigier, Cíntia M.C. Grion, Josiane Festti, Ana Luiza Mezzaroba, José Andrade, Marianne S. Camargo, Adriano F. Teixeira, José de S. Andrade, Michele M.G. de Godoy, Andréia de F. T. de Mendonça, Mara L.F.S. Mendes, Renata C.I.C. Beltrão, Edson Romano, Marcelo L.P. Romano, Andre F. Costa, Jorge Farran, Felipe Dal-Pizzol, Danusa Damásio, Renata Gonçalves, Émerson B. da Silva, Luiz de F. Ferreira, Rafael L. da Costa, Kellen Lopes, Miquéias M.L. Silva, Douglas L.A.B. de Matos, Renata de A. Marques, Glauco A. Westphal, Miriam C. Machado, Juliano Ramos, Luiz M.S. Malbouisson, Bruno N. Lucena, Marlus M. Thompson, Lanese M. Figueiredo, Luana F. Mourão, Thiago S. Garces, Israel da S. Maia, Jaqueline F. Rohr, Fernanda Fontanela, Cassia P. B. Martins, Álvaro Rea, Fernanda Reese, Mirella Oliveira, André L. N. Gobatto, Luciana S. de Mattos, Carolaine B. de Oliveira, Meton S. de Alencar, Jussara A. Arraes, João G.T. Alves, Thiago C. De Morais, Antônio A. P. Fagundes, Roberta T. Tallarico, Thais Coutinho, Ronald Torres, Fernando J.S. Ramos, Fernanda C. Athalla, Mauricio H.C. dos Santos, Paulo M.G. Nose, Cássia R. Shinotsuka, Pedro Kurtz, Bruno Guimarães, Luciana G. Pereira, Raquel B. Jupato, Bruno de A. Bravim, Marcos F. Knibel, Allan S. da Silva, Vinícius G. de Luca, Niklas Soderberg, Roseny dos R. Rodrigues, Luis E.P. Pfingsten, Cassiano Teixeira, José H.D. Barth, Giselle C. Pratini, Luiz Dalfior, Márcio H. Kai, Sérgio Blecher, Hugo C. A. Urbano, Lucas L. Carvalho, Danielle C. A. Moreira, Ana L. S. Bernardes, Vandack A. Nobre, Paula F. Vassallo, Cecília G. Ravetti, Ho Y. Li, Vivian V. T. Sales, Renata Guazzelli, Rafael D. de Oliveira, Leandro Pozzo, Leandro U. Taniguchi, Pedro V. Mendes, Suzana M. A. Lobo, Miriam Machado, Ana B. B. Camacho, Pablo O. Tomba, Fred C. T. Lizidatti, Walter C. G. Baptista, Aline R. Moreira, Manoela M. de Sousa, Marcelo O. Santos, Karla Moretto, Priscilla A. de Martins, Liz M. L. de Souza, Thiago R. Sequeira, Manoel M. S. Pedrinha, Marcone L. S. da Rocha, Francisco R. V. Saleiro, Tatiana M. Clementino, Hélio P. Guimarães, Marcos C. R. Mello, Mirella C. de Oliveira, Fernanda B. Reese, Denise M. Ferreira, Fernanda A. F. Gonçalves, Roberta M. L. Roepke, Bruno M. Tomazini, Sidiner M. Vaz, Miria Bonjour Laviola, Thiago D. Correa, Roger M. Alencar, Denise N. Freitas, Heitor P. Póvoas, Liliane B. S. Passos, Juliane de M. Silva
Journal: JAMA (2021)

Slower intravenous fluid infusion rates could reduce the formation of tissue edema and organ dysfunction in critically ill patients; however, there are no data to support different infusion rates during fluid challenges for important outcomes such as mortality.To determine the effect of a slower infusion rate vs control infusion rate on 90-day survival in patients in the intensive care unit (ICU).Unblinded randomized factorial clinical trial in 75 ICUs in Brazil, involving 11 052 patients requiring at least 1 fluid challenge and with 1 risk factor for worse outcomes were randomized from May 29, 2017, to March 2, 2020. Follow-up was concluded on October 29, 2020. Patients were randomized to 2 different infusion rates (reported in this article) and 2 different fluid types (balanced fluids or saline, reported separately).Patients were randomized to receive fluid challenges at 2 different infusion rates; 5538 to the slower rate (333 mL/h) and 5514 to the control group (999 mL/h). Patients were also randomized to receive balanced solution or 0.9% saline using a factorial design.The primary end point was 90-day survival.Of all randomized patients, 10 520 (95.2%) were analyzed (mean age, 61.1 years [SD, 17.0 years]; 44.2% were women) after excluding duplicates and consent withdrawals. Patients assigned to the slower rate received a mean of 1162 mL on the first day vs 1252 mL for the control group. By day 90, 1406 of 5276 patients (26.6%) in the slower rate group had died vs 1414 of 5244 (27.0%) in the control group (adjusted hazard ratio, 1.03; 95% CI, 0.96-1.11; P = .46). There was no significant interaction between fluid type and infusion rate (P = .98).Among patients in the intensive care unit requiring fluid challenges, infusing at a slower rate compared with a faster rate did not reduce 90-day mortality. These findings do not support the use of a slower infusion rate.ClinicalTrials.gov Identifier: NCT02875873.