tbuckley/cabot-search huggingface dataset:
Quality of Life of Adult Patients With Attention-Deficit/Hyperactivity Disorder Taking Methylphenidate—Reply
Authors: Alexandra Philipsen, Ludger Tebartz van Elst, Erika Graf
Journal: JAMA Psychiatry (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Comparison of bone marrow and PBPC FOU allogeneic sct in myelodysplastic syndromes. A retrospective study on behalf of the EBMT
Authors: Ph Guardiola, V. Runde, A. Bacigalupo, T. Ruutu, F. Locatelli, M. A. Boogaerts, A. Pagliuca, J. J. Cornelissen, A. Van Biezen, R. Brand, D. Niederwieser, E. Gluckman, Th M. De Witte
Journal: Blood (2000)
Evaluation of mid-term (6-12 months) neurotoxicity in B-cell lymphoma patients treated with CAR T cells: a prospective cohort study
Authors: Didier Maillet, Catherine Belin, Christine Moroni, Stefania Cuzzubbo, Renata Ursu, Lila Sirven-Villaros, Roberta Di Blasi, Catherine Thieblemont, Antoine F Carpentier
Journal: Neuro-Oncology (2021)

Chimeric antigen receptor-modified T (CAR T) cells are profoundly changing the standard of care in B-cell malignancies. This new therapeutic class induces a significant number of acute neurotoxicity, but data regarding mid- and long-term neurological safety are scarce. We evaluated mid-term neurological safety, with special emphasis on cognitive functions, in a series of adults treated with CAR T cells.Patients treated in a single center with CD19-targeted CAR T cells for a relapsing B-cell lymphoma were prospectively followed up by neurologists. Before CAR T-cell infusion, all patients underwent neurological examinations with neuropsychological testing and filled out questionnaires assessing anxiety, depression, and cognitive complaints. Patients surviving without tumor progression were re-evaluated similarly, 6-12 months later.In this prospective cohort of 56 consecutive adult patients treated with CAR T cells, 27 were eligible for mid-term evaluation (median time 7.6 months). Twelve patients developed an acute and reversible neurotoxicity with median duration time of 5.5 days. In all patients, neurological examination on mid-term evaluation was similar to baseline. In self-assessment questionnaires, 63% of patients reported clinically meaningful anxiety, depression, or cognitive difficulties at baseline, a number reduced to 44% at the time of mid-term evaluation. On cognitive assessments, no significant deterioration was found when compared to baseline, in any cognitive functions assessed (verbal and visual memory, executive functions, language, and praxis), even in patients who developed acute neurotoxicity.In this cohort of patients treated with CD19-targeted CAR T cells, we found no evidence for neurological or cognitive toxicity, 6-12 months after treatment.
Recurrent sustained ventricular tachycardia: structure and ultrastructure of subendocardial regions in which tachycardia originates.
Authors: J JFenoglio, T DPham, A HHarken, L NHorowitz, M EJosephson, A LWit
Journal: Circulation (1983)

Surgical resection of the endocardium and subendocardium often abolishes chronic recurrent sustained ventricular tachycardia in patients with healed myocardial infarcts or ventricular aneurysms, presumably by interrupting the reentrant pathway. To define the morphologic characteristics of cells in the reentrant pathway, we studied the histology and ultrastructure of the endocardial resections of 23 patients who underwent this procedure. Bundles of apparently viable myocardial fibers embedded in dense fibrous tissue were identified throughout the endocardial resections from all patients. These bundles of cells were separated from one another by fibrous tissue but extended uninterrupted to the margins of the surgical resection. In 14 patients Purkinje fibers were identified beneath the thickened endocardium whereas the remaining bundles were composed of ventricular muscle. The Purkinje fibers appeared to have normal ultrastructure and ventricular cells with both normal and abnormal ultrastructures were pres...
Technetium 99m stannous pyrophosphate myocardial imaging in patients with and without left ventricular aneurysm.
Authors: MAhmad, J PDubiel, T AVerdon, R HMartin
Journal: Circulation (1976)

To further explore the usefulness of technetium 99m pyrophosphate (99mTc-PYP) myocardial imaging and test its validity in the diagnosis of acute myocardial infarction, 99mTc-PYP myocardial scintigrams were performed in 50 patients. Out of 28 patients with acute myocardial infarction, myocardial scintigrams demonstrated localized activity in the 15 patients with transmural, and diffuse activity in the 13 patients with subendocardial myocardial infarction. Twenty-two patients with significant coronary artery disease documented by coronary angiography but without acute myocardial infarction were also studied. Nine of ten patients with clinical evidence of left ventricular aneurysm from previous myocardial infarction and definite left ventricular dyskinesis had positive scintigrams with activity localized to the site of the wall motion abnormality. Two of five patients without definite aneurysm but with left ventricular akinesis also had localized uptake in the involved area of the left ventricle. Seven patie...
Simplitigs as an efficient and scalable representation of de Bruijn graphs
Authors: Karel Břinda, Michael Baym, Gregory Kucherov
Journal: Genome biology (2021)

Abstract de Bruijn graphs play an essential role in bioinformatics, yet they lack a universal scalable representation. Here, we introduce simplitigs as a compact, efficient, and scalable representation, and ProphAsm, a fast algorithm for their computation. For the example of assemblies of model organisms and two bacterial pan-genomes, we compare simplitigs to unitigs, the best existing representation, and demonstrate that simplitigs provide a substantial improvement in the cumulative sequence length and their number. When combined with the commonly used Burrows-Wheeler Transform index, simplitigs reduce memory, and index loading and query times, as demonstrated with large-scale examples of GenBank bacterial pan-genomes.
Double ligation-assisted endoscopic submucosal resection for rectal neuroendocrine tumors
Authors: Wei Liu, Xiang-Lei Yuan, Bing Hu
Journal: Endoscopy (2021)

Rectal neuroendocrine tumors (NETs) are rare neoplasms with a relatively good prognosis. Currently, the first choice of treatment is endoscopic resection if the rectal NET is ≤ 10 mm because of the low risk of metastasis [1] [2]. Although conventional endoscopic mucosal resection (EMR) was considered an option for rectal NETs, it is difficult to achieve deep resection margins because most rectal NETs invade the submucosal layer. Therefore, modified EMR, including EMR with ligation (EMR-L) and EMR after circumferential incision, is widely performed because it has a low technical burden and short procedure time compared with endoscopic submucosal dissection [3]. EMR-L was recently introduced for securing a deep resection margin easily and safely; however, according to previous reports, the R0 resection rate varies from 86.2 % to 92.5 % [4] [5].
Gastrointestinal Bleeding In Covid-19 Patients: A Systematic Review And Meta-Analysis
Authors: G Marasco, M Maida, GC Morreale, M Licata, C Cremon, V Stanghellini, G Barbara
Journal: Endoscopy (2021)

Aims The novel SARS-CoV-2 disease (COVID-19) has been reported to affect the gastrointestinal (GI) system with a wide variety of symptoms, including GI bleeding. The aim of this meta-analysis is to estimate the rate of GI bleeding of patients infected with SARS-CoV-2.
Mechanism of abnormal interventricular septal motion during delayed left ventricular activation.
Authors: W CLittle, R CReeves, JArciniegas, R EKatholi, E WRogers
Journal: Circulation (1982)

To evaluate the mechanism of the abnormal motion of the interventricular septum (IVS) seen echocardiographically in some patients with relatively delayed ventricular activation, we simultaneously recorded high-fidelity left and right ventricular pressures and electrograms and echocardiograms of the IVS in nine open-chest dogs. During sinus rhythm and during left IVS pacing, the IVS was activated from left to right, preejection left ventricular pressure exceeded right ventricular pressure, and IVS motion was normal. During right ventricular pacing from the outflow tract, apex, free wall or right IVS was activated from right to left, right ventricular pressure increased before left ventricular pressure and simultaneously there was an abrupt posterior IVS motion. Simultaneous pacing from the right IVS and left ventricular free wall activated the IVS from right to left and produced a normal transseptal preejection pressure gradient and normal IVS motion. Simultaneous pacing from the left IVS and right ventric...
Transient intermittent lymphocyte activation is responsible for the instability of angina.
Authors: G GSerneri, RAbbate, A MGori, MAttanasio, FMartini, BGiusti, PDabizzi, LPoggesi, P AModesti, FTrotta
Journal: Circulation (1992)

BACKGROUNDBlood clotting activation is an important component of the inflammatory response; the outbursts of unstable angina are usually associated with increased thrombin formation and coronary mural thrombosis.METHODS AND RESULTSTo investigate 1) whether monocyte activation is responsible for the enhanced thrombin formation during bursts of unstable angina and 2) what mechanism(s) might be responsible for monocyte activation, we studied patients with unstable angina (n = 31), stable effort angina (n = 23), left endoventricular thrombosis (n = 8), and control subjects (n = 44), measuring plasma fibrinopeptide A (FPA) levels and the capacity of monocytes to express procoagulant activity (PCA) and of lymphocytes to modulate this expression. Patients with unstable angina and patients with endoventricular thrombosis had significantly (p less than 0.0001) higher FPA plasma levels than patients with effort angina and control subjects. However, only monocytes from unstable angina patients expressed significantl...
Preliminary Results of Artificial Intelligent Application in Colonoscopic Polyps Detection in Vietnam
Authors: H Dao, H Le, B Nguyen, H Nguyen, H Lam, L Dao, T Nguyen, S Dinh, H Vu
Journal: Endoscopy (2021)

Aims The data from AI applications in colorectal polyps detection in developing countries like Vietnam is still lacking. This study aims to build a deep learning model for colorectal polyps detection in colonoscopy images and validate the accuracy in testing dataset.
Intermittent ischemia produces a cumulative depletion of mitochondrial adenine nucleotides in the isolated perfused rat heart.
Authors: G KAsimakis, G SSandhu, V RConti, L ASordahl, J BZwischenberger
Journal: Circulation Research (1990)

The purpose of the present study was to determine if repetitive myocardial ischemia would result in the cumulative loss of mitochondrial adenine nucleotides. Isolated perfused rat hearts were subjected to continuous or intermittent ischemia. A single 5-minute period of continuous ischemia did not result in a significant decrease in the mitochondrial adenine nucleotide pool; a single 10-minute period of ischemia resulted in a decrease of approximately 17%. Next, the adenine nucleotide content of mitochondria from preischemic and 30-minute continuous ischemic hearts was compared with two groups of hearts undergoing intermittent ischemia (both groups receiving a total of 30 minutes of ischemia). One group received three 10-minute episodes of ischemia interrupted by 5-minute periods of reperfusion (3 x 10-minute intermittent ischemia); the other intermittent ischemic group received six 5-minute episodes of ischemia interrupted by 5-minute periods of perfusion (6 x 5-minute intermittent ischemia). The mitochon...
Catecholamine metabolic pathways and exercise training. Plasma and urine catecholamines, metabolic enzymes, and chromogranin-A.
Authors: P JRogers, G MTyce, R MWeinshilboum, D TO'Connor, K RBailey, A ABove
Journal: Circulation (1991)

BACKGROUNDBecause acute exercise increases systemic catecholamines, we sought to determine whether exercise training would alter daily or exercise-related catecholamine release and inactivation.METHODS AND RESULTSIn 24-hour urine collections, catecholamines and metabolites provided indexes of overall oxidative deamination, sulfation, and O-methylation. Plasma catecholamines, the sulfoconjugates of each, and chromogranin-A were determined at rest and during exercise in 10 well-trained male subjects and nine minimally trained male subjects (maximal oxygen uptake 55.2 and 42.5 ml/kg/min, respectively), and levels of activities of catechol-O-methyltransferase (COMT), monoamine oxidase B (MAO-B), and thermolabile phenolsulfotransferase (TL-PST) were also determined. Plasma-free catecholamines showed minimal differences between the two groups at submaximal exercise (4 minutes) but large differences at maximal exercise, reflecting the different exercise levels attained. Inactivation of plasma catecholamines by s...
Balloon occlusion of atrial septal defect to assess right ventricular capability in hypoplastic right heart syndrome.
Authors: J LBass, B PFuhrman, J ELock
Journal: Circulation (1983)

Early surgery for forms of hypoplastic right heart syndrome may increase right ventricular size but could leave the patient with a residual right-to-left atrial shunt. Previous attempts to assess the capability of the right ventricle to accept systemic venous return have relied on angiographic estimates of tricuspid valve and right ventricular sizes. Since the minimum adequate sizes have not been established, we used a more physiologic technique of temporarily occluding the interatrial communication with a balloon-tipped catheter at cardiac catheterization in six consecutive patients. Five patients tolerated complete occlusion, although the tricuspid valve anulus diameter was less than the fifth percentile in all, and right ventricular volume was less than the fifth percentile in four. These five underwent surgical closure of an interatrial communication without evidence of postoperative systemic venous hypertension. Attempted occlusion in the sixth patient caused profound systemic venous hypoxia and surg...
Reply to Thomson, to Neder <i>et al</i>., and to Wouters
Authors: MeiLan K. Han, Alvar Agusti, Bartolome R. Celli, Gerard J. Criner, David M. G. Halpin, Nicolas Roche, Alberto Papi, Robert A. Stockley, Jadwiga Wedzicha, Claus F. Vogelmeier
Journal: American Journal of Respiratory and Critical Care Medicine (2021)
Active cytomegalovirus infection of arterial smooth muscle cells in immunocompromised rats. A clue to herpesvirus-associated atherogenesis?
Authors: M CPersoons, M JDaemen, J HBruning, C ABruggeman
Journal: Circulation Research (1994)

The susceptibility of medial and neointimal arterial smooth muscle cells (SMCs) to acute cytomegalovirus (CMV) infection was investigated in immunocompetent and immunocompromised rats. The left common carotid artery of all the rats was injured by balloon catheterization. On days 14 and 17 after injury, rats were either intravenously infected with a rat CMV (RCMV) or mock-infected. Active RCMV infection was shown in the neointima of the injured arteries of immunosuppressed rats, characterized by specific cytopathological changes in hematoxylin-eosin-stained sections and by the presence of early viral antigens and the presence of the virus at different stages of maturation at the electron-microscopic level. Viral genome was shown as well by use of in situ hybridization procedures. However, medial cells were hardly ever infected, and RCMV did not infect neointimal parts that were recovered by endothelial cells. No infection was seen in control right carotid arteries or in the injured arteries of immunocompet...
Risk stratification for 1 year survival based on characteristics identified in the early hours of acute myocardial infarction. The Western Washington Intracoronary Streptokinase Trial.
Authors: M LStadius, KDavis, CMaynard, J LRitchie, J WKennedy
Journal: Circulation (1986)

We evaluated the relationship between baseline factors defined at 4.6 +/- 2.1 hr after onset of acute myocardial infarction and 1 year survival in 245 patients entered in the Western Washington Intracoronary Streptokinase Trial. Univariate statistics identified a significant relationship between 10 of these factors and survival. Multivariate analysis identified three factors as being most closely related to survival: (1) left ventricular ejection fraction (LVEF) (p less than .0001), (2) treatment with streptokinase (p = .03), and (3) location of infarction (p = .04). Mathematic models based on this analysis and applied to our patients identified high- and low-risk subgroups for 1 year mortality. Patients receiving standard, not interventional, therapy with anterior infarction and an LVEF of 50% or less and those with inferior infarction and an LVEF of 39% or less comprised the high-risk group. For patients receiving standard therapy, 1 year mortality was 41% in the high-risk group and 4% in the low-risk g...
Nonuniform course of left ventricular pressure fall and its regulation by load and contractile state.
Authors: A FLeite-Moreira, T CGillebert
Journal: Circulation (1994)

BACKGROUNDEffects of systolic left ventricular pressure (LVP) on rates of pressure fall remain incompletely understood. This study analyzed phase-plane dP/dt versus LVP plots to differentiate between accelerating and decelerating effects and to investigate the variability in reported load effects on rates of LVP fall.METHODS AND RESULTSAbrupt aortic occlusions were performed by inflating a balloon positioned in the ascending aorta of anesthetized open-chest dogs (n = 17). The occlusions resulted in clamp elevations of systolic LVP. In protocol A, the elevations of systolic LVP induced by total aortic occlusions were timed at early, mid, and late ejection. The magnitude of the elevations was 36.0 +/- 3.6 mm Hg for early, 11.6 +/- 0.6 mm Hg for mid, and negligible for late occlusions. The course of LVP fall appeared to be more complex than previously appreciated. Pressure fall might be subdivided in an initial accelerative phase, an intermediate decelerative phase, and a terminal decelerative phase. The ini...
Fixed coupling: different mechanisms revealed by exercise-induced changes in cycle length.
Authors: E LMichelson, JMorganroth, J FSpear, J AKastor, M EJosephson
Journal: Circulation (1978)

Fixed coupled ventricular premature depolarizations (VPDs) are usually considered reentrant; recent experimental models have demonstrated that parasystolic rhythms may also appear in fixed coupled patterns. To analyze the mechanisms of fixed coupled VPDs, 60 exercise tests were chosen to evaluate the response of VPD coupling intervals to changes in cycle length of the dominant supraventricular rhythm. Selection criteria included the presence of frequent, unifocal VPDs that were fixed coupled (variation less than or equal to 80 msec) at any one cycle length, with the persistence of VPDs at several different cycle lengths. Three patterns of response of coupling intervals to changes in cycle length were noted: 1) 32 patients with a direct linear relation (r greater than or equal to 0.9) of coupling intervals to cycle length; 2) 16 patients with coupling intervals fixed, independent of cycle length; and 3) 12 patients with no consistent relation over a wide range of cycle lengths. Two patients in group 2 and ...
ACC/AHA guidelines for the early management of patients with acute myocardial infarction. A report of the American College of Cardiology/American Heart Association Task Force on Assessment of Diagnostic and Therapeutic Cardiovascular Procedures (subcommittee to develop guidelines for the early management of patients with acute myocardial infarction).
Authors: R MGunnar, P DBourdillon, D WDixon, VFuster, R BKarp, J WKennedy, F JKlocke, E RPassamani, BPitt, ERapaport
Journal: Circulation (1990)
Migraine: epidemiology and systems of care
Authors: Messoud Ashina, Zaza Katsarava, Thien Phu Do, Dawn C Buse, Patricia Pozo-Rosich, Aynur Özge, Abouch V Krymchantowski, Elena R Lebedeva, Krishnamurthy Ravishankar, Shengyuan Yu, Simona Sacco, Sait Ashina, Samaira Younis, Timothy J Steiner, Richard B Lipton
Journal: The Lancet (2021)
Intrarenal Resistive Index after Renal Transplantation
Authors: Nagaraju Sarabu
Journal: New England Journal of Medicine (2014)

Naesens et al. (Nov. 7 issue)1 published their findings of a well-conducted study looking at the relationship between intrarenal resistive indexes in renal allografts and allograft dysfunction. With regard to the protocol-specified measurements, higher resistive indexes were not associated with allograft dysfunction but were associated with older recipient age and increased mortality. After reading the article, my colleagues and I had a few questions and comments. First, what is the rationale for using a cutoff value of 0.80 to distinguish a lower resistive index from a higher resistive index and for treating the resistive index as a categorical variable when it is in fact a continuous variable? Second, the intraobserver variability and interobserver variability in the study were very low at less than 5% each, but we wonder if this will hold true for the external validity of the results. Third, noninvasive assessment of renal-allograft function is an actively pursued area of investigation in many centers, including ours. In that regard, various types of magnetic resonance imaging (MRI), including blood oxygen level–dependent MRI,2 arterial spin labeling MRI,3 and diffusion-weighted MRI,4 also seem to have shown promising results.