tbuckley/cabot-search huggingface dataset:
Economic Costs of Diabetes in the U.S. in 2012
Journal: Diabetes Care (2013)

This study updates previous estimates of the economic burden of diagnosed diabetes and quantifies the increased health resource use and lost productivity associated with diabetes in 2012.The study uses a prevalence-based approach that combines the demographics of the U.S. population in 2012 with diabetes prevalence, epidemiological data, health care cost, and economic data into a Cost of Diabetes Model. Health resource use and associated medical costs are analyzed by age, sex, race/ethnicity, insurance coverage, medical condition, and health service category. Data sources include national surveys, Medicare standard analytical files, and one of the largest claims databases for the commercially insured population in the U.S.The total estimated cost of diagnosed diabetes in 2012 is $245 billion, including $176 billion in direct medical costs and $69 billion in reduced productivity. The largest components of medical expenditures are hospital inpatient care (43% of the total medical cost), prescription medications to treat the complications of diabetes (18%), antidiabetic agents and diabetes supplies (12%), physician office visits (9%), and nursing/residential facility stays (8%). People with diagnosed diabetes incur average medical expenditures of about $13,700 per year, of which about $7,900 is attributed to diabetes. People with diagnosed diabetes, on average, have medical expenditures approximately 2.3 times higher than what expenditures would be in the absence of diabetes. For the cost categories analyzed, care for people with diagnosed diabetes accounts for more than 1 in 5 health care dollars in the U.S., and more than half of that expenditure is directly attributable to diabetes. Indirect costs include increased absenteeism ($5 billion) and reduced productivity while at work ($20.8 billion) for the employed population, reduced productivity for those not in the labor force ($2.7 billion), inability to work as a result of disease-related disability ($21.6 billion), and lost productive capacity due to early mortality ($18.5 billion).The estimated total economic cost of diagnosed diabetes in 2012 is $245 billion, a 41% increase from our previous estimate of $174 billion (in 2007 dollars). This estimate highlights the substantial burden that diabetes imposes on society. Additional components of societal burden omitted from our study include intangibles from pain and suffering, resources from care provided by nonpaid caregivers, and the burden associated with undiagnosed diabetes.
OZONE IN AIRCRAFT
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diaphragmatic Paralysis
Authors: Amos D. Korczyn
Journal: JAMA (1977)

<h3>To the Editor.—</h3> The recent article, "Transient Paralysis of the Phrenic Nerve Associated With Head Injury" by Prasad and Athreya (236:2532, 1976) contains an error in referencing. The authors quote Keltz et al<sup>1</sup>as demonstrating reduced movements of the diaphragm on the side of hemiplegia in patients with stroke. In fact (and as can be seen from the title of the article by Keltz et al), these authors made no observation on hemiplegic patients. Prasad and Athreya may have intended to refer to another paper<sup>2</sup>in which we demonstrated reduced excursions of the hemidiaphragm on the paralyzed side in stroke patients. In another paper<sup>3</sup>we correlated the position of the two hemidiaphragmatic leaves in routine chest x-ray films of stroke patients and compared the results with a control group. Elevation of the left hemidiaphragm was common in patients with left hemiparesis or hemiplegia, while right hemidiaphragm elevation
Abstract 2116: Cariprazine is a potent chemo-adjuvant against multidrug resistant colon and lung cancer
Authors: Noor Hussein, Angelique Nyinawbera, Haneen Amawi, Amit Tiwari
Journal: Cancer Research (2019)

Abstract Multidrug resistance (MDR) is considered a continuing clinical problem, reducing the efficacy of cancer chemotherapy. The over expression of the ATP - binding cassette (ABC) family G2 (ABCG2) transporter is considered to be one of the main mechanisms responsible for mediating MDR in cancer. Molecular modeling studies have shown the significant affinity and binding mode of cariprazine, a dopamine D3-preferring D2/D3 receptor partial agonist, to the drug binding cavity of ABCG2 with a Glide XP score of the -5.761. Therefore, in this in vitro study, we determined the effect of cariprazine in increasing the efficacy of MX (an ABCG2 substrate) in the ABCG2 overexpressing cancer cell lines H460-MX20 and S1M1-80. Also, studies conducted to determine whether cariprazine is a reversal compound that specifically targets the ABCG2 protein. Alone, cariprazine, at concentrations up to 20 μM, did not significantly decrease cell viability. Cariprazine, at concentrations ranging from 1 to 20 μM, did not significantly alter the cytotoxicity of mitoxantrone (MX) in the parental non-small cell cancer cell line, H460 and colon cancer cell S1. However, cariprazine (1-20 μM) significantly enhanced the efficacy of ABCG2 substrate antineoplastic drug MX in the ABCG2- overexpressing MDR cell line, H460-MX20 and S1M1-80, by reducing the resistance fold from 28 to 1 and from 93 to 1.33, respectively. The intracellular accumulation of rhodamine 123 in the ABCG2-overexpressing cells, S1M1-80 was significantly increased by the addition of cariprazine, in a concentration-dependent manner (1 - 20 μM). Interestingly, 10 or 20 μM of cariprazine significantly decreased the expression levels of the ABCG2 protein in the colon and lung cancer cell lines, suggesting that cariprazine inhibits both the function and expression of ABCG2 transporters at non-toxic concentrations. Overall, our results suggest that cariprazine, via several distinct mechanisms, can re-sensitize resistant cancer cells to mitoxantrone. Citation Format: Noor Hussein, Angelique Nyinawbera, Haneen Amawi, Amit Tiwari. Cariprazine is a potent chemo-adjuvant against multidrug resistant colon and lung cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2116.
ORIGINAL INVESTIGATIONS ON THE NATURAL HISTORY, (SYMPTOMS AND PATHOLOGY) OF YELLOW FEVER. 1854-1894.
Authors: JOSEPH JONES
Journal: JAMA (1895)

<h3>Chapter VI.</h3><h3>Case 8.</h3> — Double pneumonia, bloody sputa, recovery. Robert Hanley; Irishman; came to America in 1846 and has been living in New Orleans since 1847. Weighs 150 pounds; florid complexion, light hair and blue eyes. On Jan. 6, 1877, while working in the hold of a ship, which was very close and hot, was thrown into a great heat and profuse perspiration. Being called suddenly, he left the ship without his coat (his shirt being saturated with perspiration), went on shore and was exposed to a cold wind, and in a few minutes was seized with a severe pain in the left side below the seventh rib. The pain continued to increase on the seventh and eighth, and upon the last day he began to cough and to expectorate thick, bright red sputa. Could not lie on the right side in consequence of the pain and oppression of
EDITORIAL NOTES.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of Chlorinated Drinking Water on Human Lipid Metabolism
Authors: Robert G. Wones, Charles J. Glueck
Journal: Environmental Health Perspectives (1986)

Atherosclerosis with its complications is the most important health problem affecting American adults. The levels of serum cholesterol, of high and low density lipoproteins, and of apolipoproteins A1, A2, and B are major risk factors for the development of atherosclerotic lesions. Animal studies suggest that chlorinated drinking water may elevate the serum cholesterol. Studies are too limited to confirm or refute this effect in humans. Since millions of humans have and have had daily exposure to chlorinated drinking water, it is essential to study the effects of such exposure on human lipid metabolism. We have begun a protocol to discover whether consuming chlorinated drinking water elevates serum cholesterol and the other lipid components of blood known to be associated with atherosclerosis. This protocol has been designed to improve the chance of observing an effect while preserving the ability to generalize the data.
Thirty-Seventh Annual Symposium on Fundamental Cancer Research
Journal: JNCI Journal of the National Cancer Institute (1983)

Journal Article Thirty-Seventh Annual Symposium on Fundamental Cancer Research Get access JNCI: Journal of the National Cancer Institute, Volume 71, Issue 5, November 1983, Page 1101, https://doi.org/10.1093/jnci/71.5.1101-b Published: 01 November 1983
Prothrombin Time
Authors: BERNARD A. COOPER
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 April 1982Prothrombin TimeBERNARD A. COOPER, M.D., MAVIS LEZNOFF, R.T.BERNARD A. COOPER, M.D.Search for more papers by this author, MAVIS LEZNOFF, R.T.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-4-535 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We have attempted to duplicate the study of Palmer and associates (1) because of the potential effect in anticoagulant control of change of prothrombin time with storage. Twenty patients receiving warfarin sodium (Coumadin; Endo Laboratories, Inc., Garden City, New York) on long-term anticoagulant therapy were studied at a regular clinic. Duplicate blood samples 4.5 mL each were taken by plastic syringe into 13-by-100-mm glass tubes containing 0.5 mL of buffered citrate solution (Becton Dickinson; Rutherford, New Jersey), and into 12-by-75-mm polypropylene tubes containing 0.5 mL of 3.8% sodium citrate. One of each was centrifuged at 2000 g...Reference1. PALMERKESSLERGRALNICK RCH. Misinterpretation of prothrombin time in warfarin anticoagulation [Letter]. Ann Intern Med. 1981;95:393-4. LinkGoogle Scholar1. PALMERKESSLERGRALNICK RCH. Misinterpretation of prothrombin time in warfarin anticoagulation [Letter]. Ann Intern Med. 1981;95:393-4. LinkGoogle Scholar2. PALMERGRALNICK RH. Cold-induced contact surface activation of the prothrombin time in whole blood. Blood. 1982;59:38-42. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Royal Victoria Hospital Montreal, Quebec PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1982Volume 96, Issue 4Page: 535-536KeywordsAnticoagulant therapyAnticoagulantsBloodProthrombin timeSodium Issue Published: 1 April 1982 PDF downloadLoading ...
Theories of ethics and medical practice
Authors: C. D. Leake
Journal: JAMA (1969)

There is much popular and professional confusion over ethics. It is important at once to realize that "ethics" is not a single agreed-upon system of moral conduct, but rather that there are many ethics and many theories of how it is best to behave. In medical practice, the confusion is heightened by the frequent tendency to think of etiquette as ethics. <h3>Social and Professional Control of Medicine</h3> Current technical advance in biomedical endeavor, such as organ transplantation and fertility control, has brought a bewildering shift in our understanding of moral problems associated with medical practice. No longer are there solid and immutable absolutes for our comfort. We are increasingly facing the necessity of making wise judgments promptly on the spot, on the basis of as many of the factors in the immediate situation as we can recognize and with as full an understanding as possible of the consequences of our
Infant Mortality—United States, 1990
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pneumocystis carinii pneumonia: a major complication of immunosuppressive therapy in patients with Wegener's granulomatosis.
Authors: F Vincent, T A Bensoussan
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

"Pneumocystis carinii pneumonia: a major complication of immunosuppressive therapy in patients with Wegener's granulomatosis.." American journal of respiratory and critical care medicine, 152(6), p. 2202
DISLOCATIONS OF THE CARPAL SEMILUNAR BONE
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dark plaques in nether regions. A sign of carcinoma in situ
Authors: J. M. Burket
Journal: JAMA (1974)

UNDER the title "Multicentric Pigmented Bowen's Disease of the Groin," Lloyd<sup>1</sup>reported a case of squamous cell carcinoma in situ in a 22-year-old Yemenite man. The eruption consisted of jet-black plaques on either side of the scrotum and inner aspects of the thighs. The plaques were sharply demarcated, with the larger lesions coalescing and showing a velvety surface. Matta and Kaidbey<sup>2</sup>described a 32-year-old Lebanese man who had two brownish-black pruritic plaques of the prepuce. Both patients had biopsy specimens that showed Bowen disease, with an increased amount of epidermal and dermal pigment. I report two cases of similar multicentric eruptions in female patients. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 37-year-old white woman had a leukoplakic area of the vulva. Bowen disease was diagnosed on biopsy. A radical vulvectomy and an inguinal and iliac lymphadenectomy were performed. The pathologic report was carcinoma in situ without invasion and without
Letter: Community health specialists.
Authors: J Lucke, David Lister, G Hall
Journal: BMJ (1975)

biopsy of patients or hyperthermic indiividuals would provide material of doubtful value for detailed biochemical investigations in vitro.We have used nitrous oxide in conjunction with thiopentone to anaesthetize more than 150 susceptible pigs without triggering M.H.Our experience in pigs therefore appears to conflict with that of Ellis et al.} which incriminated nitrous oxide in a single human patient.This suggests that the aetiology is not entirely a pharmacological effect but may be associated with some other aspect of anaesthesia.The observation of Ellis et al. that M.H. may be satisfactorily treated with large doses of glucocorticoids will no doubt lead to the development of several hypotheses on the mode of action of these drugs, as occurred following the use of procaine.It should also be remembered that when no specific therapy could be recommended 36% of the patients survived.9Thus isolated case reports should be considered with caution until any new therapy can be critically appraised.'0-We are, etc.,
Medicolegal.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Updated Recommendations From the Advisory Committee on Immunization Practices in Response to Delays in Supply of Influenza Vaccine for the 2000-01 Season
Journal: JAMA (2000)

On July 14, CDC reported a substantial delay in the availability of a proportion of influenza vaccine for the 2000-01 season and the possibility of a vaccine shortage. Since then, resolution of manufacturing problems and improved yields of the influenza A (H3N2) vaccine component have averted a shortage. Although safe and effective influenza vaccine will be available in similar quantities as last year, much of the vaccine will be distributed later in the season than usual. This update provides information on the influenza vaccine supply situation and updated influenza vaccination recommendations by the Advisory Committee on Immunization Practices (ACIP) for the 2000-01 influenza season.
Is there a case for an international medical scientific press council?
Authors: D. G. Altman
Journal: JAMA (1994)

Serious abuse of editorial power is rarely publicized, but evidence that it occurs is accumulating. Authors who believe that they have been dealt with unfairly have little possibility of a hearing of their complaint, and cases cannot easily be publicized because of fears of legal action. We describe briefly three cases in which the alleged misdeeds indicate that there were legitimate questions that needed answers. In the first case, an editor republished a previously published article without the authors' permission (but stated the opposite), attacked it in an accompanying editorial, and then denied the authors the right of reply. The other cases concerned a commissioned review article that was plagiarized and an editor with an undisclosed vested interest. An appeal process is needed for authors who think that they are victims of editorial abuse of power. We suggest that the International Committee of Medical Journal Editors turn its attention to editorial misconduct and explore possible procedures for allowing authors' grievances to be heard and for possible sanctions if complaints are upheld. An International Medical Scientific Press Council might be established to produce a code of conduct for editors and a corresponding taxonomy of inappropriate editorial behavior. (<i>JAMA</i>. 1994;272:166-167)