The impact of COVID-19 on hepatitis services and civil society organisations
Authors: Chris Wingrove, Cary James, Su Wang
Journal: The Lancet. Gastroenterology & hepatology (2021)

Every 30 seconds, someone dies from viral hepatitis. With the disruptions caused by COVID-19, this health crisis has become even more urgent. We can no longer wait to act on hepatitis. People are dying because they did not receive simple interventions. People who are unaware that they are living with viral hepatitis cannot wait for testing and treatment. Pregnant mothers cannot wait for screening and prophylactic treatment. Newborn babies cannot wait for the hepatitis B birth-dose vaccination. The COVID-19 pandemic has affected hepatitis prevention, testing, treatment, and vaccination services globally.1WHOGlobal progress report on HIV, viral hepatitis and sexually transmitted infections, 2021. Accountability for the global health sector strategies 2016-2021: actions for impact.https://www.who.int/publications/i/item/9789240027077Date: 2021Date accessed: July 15, 2021Google Scholar Even before COVID-19, very few countries were on track to reach the 2030 elimination goals set by WHO.2WHOGlobal health sector strategy on viral hepatitis 2016–2021.https://apps.who.int/iris/handle/10665/246177Date: 2016Date accessed: July 15, 2021Google Scholar The pandemic has put elimination efforts further behind. Interruptions in the provision of services, coupled with delays in implementing major programmes, such as the anticipated support from Gavi, the Vaccine Alliance, for the hepatitis B birth-dose vaccine, will have dire consequences.3WHOFast-tracking the elimination of hepatitis B among mothers and children.https://www.who.int/news/item/27-07-2020-world-hepatitis-day-fast-tracking-the-elimination-of-hepatitis-b-among-mothers-and-childrenDate: 2020Date accessed: July 15, 2021Google Scholar The World Hepatitis Alliance (WHA), a global network of more than 300 community-based organisations across 100 countries, conducted a survey at the onset of the COVID-19 pandemic (March–April, 2020) about the effect of the pandemic on hepatitis services and on the people and communities that need them.4Wingrove C Ferrier L James C Wang S The impact of COVID-19 on hepatitis elimination.Lancet Gastroenterol Hepatol. 2020; 5: 792-794Summary Full Text Full Text PDF PubMed Scopus (53) Google Scholar We conducted a follow-up survey a year later to understand how front-line hepatitis services continue to be affected. The survey also sought to assess the effect of COVID-19 on organisation's planning and finances and the respondent's country's progress on hepatitis elimination. The online nine-question questionnaire (appendix pp 1–2) was distributed by email to WHA members between Jan 3 and March 23, 2021. There were 63 respondents from 33 countries representing all WHO global regions (appendix p 3). Most (55 [90%] of 61 analysable responses) respondents reported that COVID-19 had a negative impact on the hepatitis services available in their country. This finding reflects other global surveys,5Laury J Hiebert L Ward JW Impact of COVID-19 response on hepatitis prevention care and treatment: results from global survey of providers and program managers.Clin Liver Dis. 2021; 17: 41-46Crossref PubMed Scopus (21) Google Scholar including one by WHO6WHOPulse survey on continuity of essential health services during the COVID-19 pandemic.https://www.who.int/docs/default-source/coronaviruse/finalupdate_22-april-2021_summary-ppt_ehs-pulse-survey_second-round.pdf?sfvrsn=a965e121_8Date: 2021Date accessed: July 15, 2021Google Scholar on the continuity of essential health services in May to July, 2020, with a follow-up survey in 2021. Respondents to the WHO survey were government officials representing more than 100 countries. Of all the communicable diseases measured (including HIV, malaria, and tuberculosis), hepatitis had the highest ranking of disruption. Notably, the proportion of respondents who answered "do not know" for the impact of COVD-19 on the hepatitis response was much higher than for HIV. Thus, the gaps we are seeing might only be a small part of a larger problem. COVID-19 has potentially jeopardised national elimination planning for viral hepatitis due to diverted resources and attention. 43 (77%) of 56 analysable respondents to our survey reported that their country's progress towards hepatitis elimination has been affected. With governments facing the economic fallout of the COVID-19 pandemic, there is a real risk that funding will be reduced or lost for the foreseeable future. If this is the case, then many of the hard-fought advocacy wins that saw increases in domestic budget allocations would need to start again. Fear of COVID-19 has been a substantial barrier to hepatitis testing and treatment throughout the crisis. 22 (73%) of 30 respondents reported that people did not have access to their medication because they avoided health-care facilities due to COVID-19. In the 2020 survey, this fear was reported by 50% of respondents.4Wingrove C Ferrier L James C Wang S The impact of COVID-19 on hepatitis elimination.Lancet Gastroenterol Hepatol. 2020; 5: 792-794Summary Full Text Full Text PDF PubMed Scopus (53) Google Scholar Fear also affects testing, with 24 (86%) of 28 respondents reporting that the reason for people not accessing testing was avoidance of going to testing facilities due to COVID-19. In our 2020 survey, 65% of respondents cited this fear of attending testing facilities.4Wingrove C Ferrier L James C Wang S The impact of COVID-19 on hepatitis elimination.Lancet Gastroenterol Hepatol. 2020; 5: 792-794Summary Full Text Full Text PDF PubMed Scopus (53) Google Scholar Throughout the pandemic, civil society organisations have played a key role in overcoming this barrier and evolved their services to provide opportunities to test for hepatitis in settings where the community feels safe and confident during the COVID-19 crisis. Decentralised, simplified services delivered at the community level are needed more than ever for viral hepatitis. We must innovate and find ways to provide life-giving care to people in locations they trust in a person-centred approach, which might require different approaches. Differentiated care models have been successful for HIV and represent a growing trend in hepatitis C care. Our survey revealed signs that some services had returned over the pandemic, albeit not to previous levels. 27 (48%) of 56 responses reported community education and awareness raising had stopped but had now resumed at a reduced level. 28 (50%) of 56 responses reported hepatitis B vaccination had stopped but had resumed at a reduced capacity. Childhood vaccines have been substantially disrupted in many areas, jeopardising children's protection and leading to the tragic rise in hepatitis B infections in children born during the pandemic.3WHOFast-tracking the elimination of hepatitis B among mothers and children.https://www.who.int/news/item/27-07-2020-world-hepatitis-day-fast-tracking-the-elimination-of-hepatitis-b-among-mothers-and-childrenDate: 2020Date accessed: July 15, 2021Google Scholar Modelling conducted at Imperial College London showed that in a worst-case scenario, with a 60% reduction in administration of birth dose and a 20% reduction of childhood hepatitis B immunisation at age 1 year, there would be an additional 5·3 million chronic hepatitis B infections in children born between 2020 and 2030, and 1 million additional hepatitis B-related deaths among those children later on in life.3WHOFast-tracking the elimination of hepatitis B among mothers and children.https://www.who.int/news/item/27-07-2020-world-hepatitis-day-fast-tracking-the-elimination-of-hepatitis-b-among-mothers-and-childrenDate: 2020Date accessed: July 15, 2021Google Scholar 46 (81%) of 57 analysable responses reported that COVID-19 had a negative impact on their organisation's plans in 2021. Respondents reported that the restrictions implemented to tackle the pandemic would affect their ability to deliver services, raise awareness in the community, and fundraise. Most concerningly, 45 (79%) of 57 responses reported that the COVID-19 pandemic had a negative effect on their organisation's finances. Although the global health agenda looks at how we can build back better after COVID-19, there is a real danger that many viral hepatitis community organisations might not survive because of substantial financial hardship. Countries must include support of civil society organisations in their elimination planning to ensure that the vital work of community-level awareness and involvement of the affected community continues. If governments do not engage with civil society and the affected community, equity, and the reaching of key populations for viral hepatitis elimination will be at risk. This World Hepatitis Day, the global viral hepatitis community is calling for urgent action on viral hepatitis to reach elimination. The Hepatitis Can't Wait campaign calls on governments, international donors, decision-makers, and medical professionals to accelerate action to eliminate viral hepatitis and to prevent millions more infections and avoidable deaths. It is time to act. Hepatitis can't wait. CW and CJ declare grants from Gilead, AbbVie, Janssen, and Kedrion, outside the submitted work. SW declares grants from Gilead, outside the submitted work. Download .pdf (.48 MB) Help with pdf files Supplementary appendix