tbuckley/cabot-search huggingface dataset:
CHANGE IN INVASIVELY MEASURED MEAN PULMONARY ARTERY PRESSURE AFTER TRANSCATHETER MITRAL VALVE REPAIR IS ASSOCIATED WITH HEART FAILURE READMISSIONS
Authors: David Tehrani, Parntip Chertboonmuang, Pooja Desai, Jiexi Wang, Heajung Nguyen, Lisa Bang, Eric Yang, Gabriel Vorobiof, Ali Nsair, Olcay Aksoy, Marcella Calfon-Press, Rushi Parikh
Journal: Journal of the American College of Cardiology (2021)
DIFFERENTIAL OUTCOMES IN LAD AND NON-LAD VASCULAR TERRITORY BASED ON POST-PCI FFR
Authors: Shiv Kumar Agarwal, Abdul Hakeem, Malek Al-Hawwas, Negar Salehi, Kristin G. Miller, Rimsha Hasan, Mohamed Ayan, Barry Uretsky
Journal: Journal of the American College of Cardiology (2021)
Infant gut microbiome is enriched with <i>Bifidobacterium longum</i><i>ssp. infantis</i> in Old Order Mennonites with traditional farming lifestyle
Authors: Antti E. Seppo, Kevin Bu, Madina Jumabaeva, Juilee Thakar, Rakin A. Choudhury, Chloe Yonemitsu, Lars Bode, Camille A. Martina, Maria Allen, Sabrina Tamburini, Enrica Piras, David S. Wallach, R. John Looney, Jose C. Clemente, Kirsi M. Järvinen
Journal: Allergy (2021)

Abstract Background Growing up on traditional, single‐family farms is associated with protection against asthma in school age, but the mechanisms against early manifestations of atopic disease are largely unknown. We sought determine the gut microbiome and metabolome composition in rural Old Order Mennonite (OOM) infants at low risk and Rochester, NY urban/suburban infants at high risk for atopic diseases. Methods In a cohort of 65 OOM and 39 Rochester mother‐infant pairs, 101 infant stool and 61 human milk samples were assessed by 16S rRNA gene sequencing for microbiome composition and qPCR to quantify Bifidobacterium spp. and B . longum ssp. infantis ( B. infantis ), a consumer of human milk oligosaccharides (HMOs). Fatty acids (FAs) were analyzed in 34 stool and human 24 milk samples. Diagnoses and symptoms of atopic diseases by 3 years of age were assessed by telephone. Results At a median age of 2 months, stool was enriched with Bifidobacteriaceae , Clostridiaceae , and Aerococcaceae in the OOM compared with Rochester infants. B . infantis was more abundant ( p &lt; .001) and prevalent, detected in 70% of OOM compared with 21% of Rochester infants ( p &lt; .001). Stool colonized with B . infantis had higher levels of lactate and several medium‐ to long/odd‐chain FAs. In contrast, paired human milk was enriched with a distinct set of FAs including butyrate. Atopic diseases were reported in 6.5% of OOM and 35% of Rochester children ( p &lt; .001). Conclusion A high rate of B . infantis colonization, similar to that seen in developing countries, is found in the OOM at low risk for atopic diseases.
Sleep in hospitalized children and adolescents: A scoping review
Authors: Jane Hybschmann, Martha K. Topperzer, Line K. Gjærde, Peter Born, René Mathiasen, Astrid M. Sehested, Poul J. Jennum, Jette L. Sørensen
Journal: Sleep Medicine Reviews (2021)

Hospitalized children and adolescents are at risk of short sleep and subsequent adverse health effects, but little is known about actual sleep duration, the factors that cause sleep disturbances in an inpatient pediatric setting, and what has been done to promote sleep in this population. The aim of this review was to systematically identify, categorize, and synthesize the literature on sleep in children and adolescents in an inpatient setting. We searched five electronic databases (PubMed, CENTRAL, CINAHL, PsycINFO, and Scopus) and of the 3770 references identified, 28 were eligible for inclusion. From studies reporting age-specific sleep durations, we found that four out of nineteen fell within the National Sleep Foundations recommendations for age-specific sleep durations. Reported causes of sleep disturbances were primarily related to modifiable, external factors, e.g., nursing care activities and noise from equipment and other patients. Sleep-promoting interventions seemed acceptable to patients, parents, and healthcare professionals. However, the literature in this area is heterogeneous regarding methodology, reporting, and population characteristics. Our findings underline the importance of prioritizing and optimizing sleep in hospitalized pediatric patients and highlight the need for standardization in the planning and reporting of studies within this field.
Confronting Racism in Environmental Health Sciences: Moving the Science Forward for Eliminating Racial Inequities
Authors: Devon C. Payne-Sturges, Gilbert C. Gee, Deborah A. Cory-Slechta
Journal: Environmental Health Perspectives (2021)

Background: The twin pandemics of COVID-19 and systemic racism during 2020 have forced a conversation across many segments of our society, including the environmental health sciences (EHS) research community. We have seen the proliferation of statements of solidarity with the Black Lives Matter movement and commitments to fight racism and health inequities from academia, nonprofit organizations, governmental agencies, and private corporations. Actions must now arise from these promises. As public health and EHS scientists, we must examine the systems that produce and perpetuate inequities in exposure to environmental pollutants and associated health effects. Objectives: We outline five recommendations the EHS research community can implement to confront racism and move our science forward for eliminating racial inequities in environmental health. Discussion: Race is best considered a political label that promotes inequality. Thus, we should be wary of equating race with biology. Further, EHS researchers should seriously consider racism as a plausible explanation of racial disparities in health and consider structural racism as a factor in environmental health risk/impact assessments, as well as multiple explanations for racial differences in environmental exposures and health outcomes. Last, the EHS research community should develop metrics to measure racism and a set of guidelines on the use and interpretation of race and ethnicity within the environmental sciences. Numerous guidelines exist in other disciplines that can serve as models. By taking action on each of these recommendations, we can make significant progress toward eliminating racial disparities. https://doi.org/10.1289/EHP8186
META-ANALYSIS COMPARING OUTCOME COMPARISON BETWEEN DE-ESCALATED ANTIPLATELET THERAPY FROM TICAGRELOR TO CLOPIDOGREL AND CONTINUOUS THERAPY WITH TICAGRELOR FOR PATIENTS DIAGNOSED WITH ACUTE CORONARY SYNDROME STATUS POST PERCUTANEOUS CORONARY INTERVENTION
Authors: Hong Seok Lee, Reza Arsanjani, David Majdalany
Journal: Journal of the American College of Cardiology (2021)
Oncolytic adenovirus and gene therapy with EphA2-BiTE for the treatment of pediatric high-grade gliomas
Authors: Claudia Manuela Arnone, Vinicia Assunta Polito, Angela Mastronuzzi, Andrea Carai, Francesca Camassei Diomedi, Laura Antonucci, Lucia Lisa Petrilli, Maria Vinci, Francesco Ferrari, Elisa Salviato, Marco Scarsella, Cristiano De Stefanis, Gerrit Weber, Concetta Quintarelli, Biagio De Angelis, Malcolm K Brenner, Stephen Gottschalk, Valentina Hoyos, Franco Locatelli, Ignazio Caruana, Francesca Del Bufalo
Journal: Journal for ImmunoTherapy of Cancer (2021)

Background Pediatric high-grade gliomas (pHGGs) are among the most common and incurable malignant neoplasms of childhood. Despite aggressive, multimodal treatment, the outcome of children with high-grade gliomas has not significantly improved over the past decades, prompting the development of innovative approaches. Methods To develop an effective treatment, we aimed at improving the suboptimal antitumor efficacy of oncolytic adenoviruses (OAs) by testing the combination with a gene-therapy approach using a bispecific T-cell engager (BiTE) directed towards the erythropoietin-producing human hepatocellular carcinoma A2 receptor (EphA2), conveyed by a replication-incompetent adenoviral vector (EphA2 adenovirus (EAd)). The combinatorial approach was tested in vitro, in vivo and thoroughly characterized at a molecular level. Results After confirming the relevance of EphA2 as target in pHGGs, documenting a significant correlation with worse clinical outcome of the patients, we showed that the proposed strategy provides significant EphA2-BiTE amplification and enhanced tumor cell apoptosis, on coculture with T cells. Moreover, T-cell activation through an agonistic anti-CD28 antibody further increased the activation/proliferation profiles and functional response against infected tumor cells, inducing eradication of highly resistant, primary pHGG cells. The gene-expression analysis of tumor cells and T cells, after coculture, revealed the importance of both EphA2-BiTE and costimulation in the proposed system. These in vitro observations translated into significant tumor control in vivo, in both subcutaneous and a more challenging orthotopic model. Conclusions The combination of OA and EphA2-BiTE gene therapy strongly enhances the antitumor activity of OA, inducing the eradication of highly resistant tumor cells, thus supporting the clinical translation of the approach.
The ingenious mast cell: Contemporary insights into mast cell behavior and function
Authors: Joakim S. Dahlin, Marcus Maurer, Dean D. Metcalfe, Gunnar Pejler, Ronit Sagi‐Eisenberg, Gunnar Nilsson
Journal: Allergy (2021)

Mast cells are (in)famous for their role in allergic diseases, but the physiological and pathophysiological roles of this ingenious cell are still not fully understood. Mast cells are important for homeostasis and surveillance of the human system, recognizing both endogenous and exogenous agents, which induce release of a variety of mediators acting on both immune and non-immune cells, including nerve cells, fibroblasts, endothelial cells, smooth muscle cells, and epithelial cells. During recent years, clinical and experimental studies on human mast cells, as well as experiments using animal models, have resulted in many discoveries that help decipher the function of mast cells in health and disease. In this review, we focus particularly on new insights into mast cell biology, with a focus on mast cell development, recruitment, heterogeneity, and reactivity. We also highlight the development in our understanding of mast cell-driven diseases and discuss the development of novel strategies to treat such conditions.
CLINICAL OUTCOMES OF UNPROTECTED LEFT MAIN CORONARY ARTERY PERCUTANEOUS CORONARY INTERVENTION IN AUSTRALIAN NON-SURGICAL CENTRES
Authors: Laura Hanson, Sara Vogrin, Samer Noaman, Cheng Yee Goh, Diem Dinh, Jeffrey Lefkovits, Christopher Reid, Angela Brennan, Wayne Zheng, Jason Bloom, Riley Batchelor, Kawa Haji, Youlin Koh, Dion Stub, Nicholas Cox, William Chan
Journal: Journal of the American College of Cardiology (2021)
Interacting Gene Clusters and the Evolution of the Vertebrate Immune System
Authors: T. Makino, A. McLysaght
Journal: Molecular Biology and Evolution (2008)

The accession number for the GO term ''response to stimulus'' was reported inaccurately.The correct accession number is GO:0050896.This should be corrected in the caption for Table 2 and in the text in section ''Function of Genes in Interacting Gene Clusters''.This was a clerical error in the preparation of
ASPIRIN VERSUS ASPIRIN PLUS CLOPIDOGREL AS ANTITHROMBOTIC TREATMENT FOLLOWING TRANSCATHETER AORTIC VALVE IMPLANTATION- A SYSTEMATIC REVIEW AND META ANALYSIS
Authors: Aminah Abdul Razzack, Suveenkrishna Pothuru, Mounika Pusa, Krishna Teja Challa, Syed Adeel Hassan, Farah Yasmin, Tariq Jamal Siddiqui
Journal: Journal of the American College of Cardiology (2021)
SAFETY AND EFFICACY OF COLCHICINE FOR SECONDARY PREVENTION AFTER ACUTE MYOCARDIAL INFARCTION: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Kevin Buda, Michael Megaly, Jessica Padniewski, Philippe Fernand Nyembo, Maen Assali, Samuel Shabtaie, Yader Sandoval, Rawad Nasr, Santiago Garcia, Mengistu Simegn
Journal: Journal of the American College of Cardiology (2021)
CONVERSION OF CARDIOVASCULAR RANDOMIZED CONTROL TRIALS PRESENTED AT MAJOR CONFERENCES TO PUBLICATIONS
Authors: Farah Yasmin, Muhammad Khan, Pankaj Kumar, Sameer Hirji, Abdul Mannan Khan Minhas, Vanessa Blumer, Marat Fudim, Safi Khan, Ambarish Pandey, Khurram Nasir, Salim Virani, Richard Krasuski
Journal: Journal of the American College of Cardiology (2021)
LEFT VENTRICULAR ASSIST DEVICE PUMP SPEED, AORTIC VALVE CLOSURE AND INCIDENCE OF AORTIC INSUFFICIENCY
Authors: Neha Mukunda, Edo Y. Birati, Bryce V. Johnson, Joyce Wald, Pavan Atluri, Lee Goldberg, Kimberly Urgo, Sriram D. Rao, Michael Genuardi
Journal: Journal of the American College of Cardiology (2021)
CRYOABLATION VERSUS ANTIARRHYTHMIC DRUG THERAPY AS INITIAL TREATMENT FOR ATRIAL FIBRILLATION: IMPACT ON QUALITY OF LIFE
Authors: Oussama M. Wazni, Gopi Dandamudi, Nitesh Sood, Robert Hoyt, Jaret Tyler, Sarfraz Durrani, Mark Niebauer, Kevin Makati, Blair Halperin, Andre Gauri, Gustavo Morales, Jeffrey Cerkvenik, Rachelle Kaplon, Steven Nissen
Journal: Journal of the American College of Cardiology (2021)
DIFFERENCES IN MYOCARDIAL REMODLING AND TISSUE CHARACTERISTICS IN AORTIC AND MITRAL REGURGITATION
Authors: Maan Malahfji, Valentina Laura Crudo, Danai Kitkungvan, Alpana Senapati, Priyanka Bhugra, Bhupendar Tayal, Dany Debs, Mary Klosterman, Mohamad Ghosn, Duc Nguyen, Edward Graviss, Dipan Shah
Journal: Journal of the American College of Cardiology (2021)
REDUCTION IN HEART FAILURE READMISSION AND EXPECTED COST SAVINGS IN A SNF POPULATION FOLLOWING IMPLEMENTATION OF A VIRTUAL CARDIOLOGY PROGRAM
Authors: Daniel Friedman, Jana Goldberg, Syed-Samar Raza, Nodar Janas, Pete Celano, Karen Kapoor, Jina Telaraja, Maria Torres, Adam Castano, Mark Hanson, Nayan Jain, Jeffrey Wessler
Journal: Journal of the American College of Cardiology (2021)
Mumps Outbreak on a University Campus—California, 2011
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The bizarre appearance of intrathoracic extramedullary hematopoiesis during an endoscopic ultrasound examination
Authors: Rocco Trisolini, Alberto Larghi, Vanina Livi, Daniela Paioli, Alessandra Cancellieri
Journal: Endoscopy (2021)

A 61-year-old man was referred for evaluation of bilateral, intrathoracic, paravertebral masses suspicious for malignancy ([Fig. 1 a, b]). The lesions had been incidentally detected in the thoracic slices of an abdominal computed tomography (CT) performed to investigate suspected kidney stones. The patient had no thoracic complaints and had an unremarkable past medical history. Given the proximity to the esophagus, an endoscopic ultrasound (EUS) with bronchoscope was performed to rule out lung cancer. It showed the right-sided lesion as a 5.5-cm, heterogeneous mass characterized by the bizarre alternation of thick linear hyperechoic and iso-hypoechoic areas (“zebra-like” appearance) ([Video 1]). Several passes with a 22-gauge needle were performed without any complication, and the pathologic examination of both tissue cores and smears led to the diagnosis of an intrathoracic extramedullary hematopoiesis ([Fig. 2 a, b]). Hematologic laboratory tests were performed and an underlying beta thalassemia minor was finally diagnosed.
PROGNOSTIC VALUE OF ELEVATED PULSE PRESSURE FOR INHOSPITAL MORTALITY AND SHORT TERM READMISSIONS IN PATIENTS WITH SEVERE ACUTE HEART FAILURE
Authors: Miguel A. Quintana, Jose Giménez Negrete, Daniel Viveros Filártiga, Juan Ojeda Ruiz Díaz, Jorge Martínez, Leticia Gutierrez
Journal: Journal of the American College of Cardiology (2021)
TREATING TRANSTHYRETIN AMYLOID CARDIOMYOPATHY: A COMPARISON OF DIFLUNISAL AND TAFAMIDIS
Authors: Amir Gilad, Tracy Joshi, Lisa Mendelson, John Berk, Vaishali Sanchorawala, Frederick Ruberg, Omar Siddiqi, Deepa Gopal
Journal: Journal of the American College of Cardiology (2021)
REDUCTION IN HOSPITAL ADMISSIONS ASSOCIATED WITH CORONARY EVENTS DURING THE COVID-19 PANDEMIC IN THE BRAZILIAN PRIVATE HEALTH
Authors: Bruno Ramos Nascimento, Luiz Eduardo V. Fróes, Ana Cristina T. Castro, Eduardo T. Fróes, Andrea Beaton, Craig Sable, Cynthia B.M. Araújo, Charles F. Souza, Larissa V. Cruz, Luisa Brant, Clara L. Fraga, Frederico V.B. Macedo, Antonio Ribeiro, Soraya D. Souza
Journal: Journal of the American College of Cardiology (2021)
Boosting 5-ALA-based photodynamic therapy by a liposomal nanomedicine through intracellular iron ion regulation
Authors: Airong Li, Chenglin Liang, Lihua Xu, Yiyang Wang, Wei Liu, Kaixiang Zhang, Junjie Liu, Jinjin Shi
Journal: Acta Pharmaceutica Sinica B (2021)

5-Aminolevulinic acid (5-ALA) has been approved for clinical photodynamic therapy (PDT) due to its negligible photosensitive toxicity. However, the curative effect of 5-ALA is restricted by intracellular biotransformation inactivation of 5-ALA and potential DNA repair of tumor cells. Inspired by the crucial function of iron ions in 5-ALA transformation and DNA repair, a liposomal nanomedicine ([email protected]/DFO) with intracellular iron ion regulation property was developed for boosting the PDT of 5-ALA, which was prepared by co-encapsulating 5-ALA and DFO (deferoxamine, a special iron chelator) into the membrane fusion liposomes (MFLs). [email protected]/DFO showed an improved pharmaceutical behavior and rapidly fused with tumor cell membrane for 5-ALA and DFO co-delivery. [email protected]/DFO could efficiently reduce iron ion, thus blocking the biotransformation of photosensitive protoporphyrin IX (PpIX) to heme, realizing significant accumulation of photosensitivity. Meanwhile, the activity of DNA repair enzyme was also inhibited with the reduction of iron ion, resulting in the aggravated DNA damage in tumor cells. Our findings showed [email protected]/DFO had potential to be applied for enhanced PDT of 5-ALA.
SAPIEN S3 ULTRA STENT STRUTS DEFORMATION SECONDARY TO SEVERELY CALCIFIED AND STENOSED ILIAC ARTERY
Authors: Sunny Goel, Faisal Saiful, Gurpreet Johal, Amit Hooda, Parasuram Melarcode Krishnamoorthy, Samin Sharma, Annapoorna Kini, George Dangas
Journal: Journal of the American College of Cardiology (2021)
THE ASSOCIATION OF PRETERM BIRTH AND CARDIOVASCULAR RISK FACTORS WITH MATERNAL NATIVITY AND DURATION OF RESIDENCE IN THE UNITED STATES AMONG NON-HISPANIC BLACK WOMEN
Authors: Garima Sharma, Ellen Boakye, Omar Dzaye, Yaa Adoma Kwapong, Sammy Zakaria, Arthur Vaught, Andreea Creanga, Laxmi Mehta, Miguel Cainzos-Achirica, Khurram Nasir, Michael Blaha, Roger Blumenthal, Xiaobin Wang
Journal: Journal of the American College of Cardiology (2021)
Dermatologist influencers on social media: Instagram Reels and TikTok interactive short videos
Authors: Mindy D. Szeto, Colby L. Presley, Kayd J. Pulsipher, Taylor Harp, Chandler W. Rundle, Torunn E. Sivesind, Melissa R. Laughter, Robert P. Dellavalle
Journal: Journal of the American Academy of Dermatology (2021)
Detect and destroy: CRISPR-based technologies for the response against viruses
Authors: Catherine A. Freije, Pardis C. Sabeti
Journal: Cell Host & Microbe (2021)

Despite numerous viral outbreaks in the last decade, including a devastating global pandemic, diagnostic and therapeutic technologies remain severely lacking. CRISPR-Cas systems have the potential to address these critical needs in the response against infectious disease. Initially discovered as the bacterial adaptive immune system, these systems provide a unique opportunity to create programmable, sequence-specific technologies for detection of viral nucleic acids and inhibition of viral replication. This review summarizes how CRISPR-Cas systems—in particular the recently discovered DNA-targeting Cas12 and RNA-targeting Cas13, both possessing a unique trans-cleavage activity—are being harnessed for viral diagnostics and therapies. We further highlight the numerous technologies whose development has accelerated in response to the COVID-19 pandemic.
IMPACT OF RENAL FAILURE ON OUTCOMES IN PATIENTS ON VA-ECMO FOR CARDIOGENIC SHOCK
Authors: Pradeep Dayanand, Edwin Grajeda Silvestri, Baher Al-abbasi, Pedro Torres, Samineh Sehatbakhsh, Mohamed Abdul Qader, Riya Job, Karla Avila, Jesus Pino, Robert Chait, Waqas Ghumman, Sajid Mirza
Journal: Journal of the American College of Cardiology (2021)
Single-cell Profiles and Prognostic Impact of Tumor-Infiltrating Lymphocytes Coexpressing CD39, CD103, and PD-1 in Ovarian Cancer
Authors: Céline M. Laumont, Maartje C.A. Wouters, Julian Smazynski, Nicole S. Gierc, Elizabeth A. Chavez, Lauren C. Chong, Shelby Thornton, Katy Milne, John R. Webb, Christian Steidl, Brad H. Nelson
Journal: Clinical Cancer Research (2021)

Abstract Purpose: Tumor-infiltrating lymphocytes (TIL) are strongly associated with survival in most cancers; however, the tumor-reactive subset that drives this prognostic effect remains poorly defined. CD39, CD103, and PD-1 have been independently proposed as markers of tumor-reactive CD8+ TIL in various cancers. We evaluated the phenotype, clonality, and prognostic significance of TIL expressing various combinations of these markers in high-grade serous ovarian cancer (HGSC), a malignancy in need of more effective immunotherapeutic approaches. Experimental Design: Expression of CD39, CD103, PD-1, and other immune markers was assessed by high-dimensional flow cytometry, single-cell sequencing, and multiplex immunofluorescence of primary and matched pre/post-chemotherapy HGSC specimens. Results: Coexpression of CD39, CD103, and PD-1 (“triple-positive” phenotype) demarcated subsets of CD8+ TIL and CD4+ regulatory T cells (Treg) with a highly activated/exhausted phenotype. Triple-positive CD8+ TIL exhibited reduced T-cell receptor (TCR) diversity and expressed genes involved in both cytolytic and humoral immunity. Triple-positive Tregs exhibited higher TCR diversity and a tumor-resident phenotype. Triple-positive TIL showed superior prognostic impact relative to TIL expressing other combinations of these markers. TIGIT was uniquely upregulated on triple-positive CD8+ effector cells relative to their CD4+ Treg counterparts. Conclusions: Coexpression of CD39, CD103, and PD-1 demarcates highly activated CD8+ and CD4+ TIL with inferred roles in cytolytic, humoral, and regulatory immune functions. Triple-positive TIL demonstrate exceptional prognostic significance and express compelling targets for combination immunotherapy, including PD-1, CD39, and TIGIT.
AORTIC VALVE PAPILLARY FIBROELASTOMA CAUSING RECURRENT CEREBROVASCULAR ACCIDENT
Authors: Michael Ahlers, Vishnu Nair, David Tehrani, Pratyaksh K. Srivastava, Jesse Currier, Jin Zhong, Alberta Warner, Marineh Bojalian, Donald Chang, Michael Ong
Journal: Journal of the American College of Cardiology (2021)
US Pediatric Emergency Department Visits for Mental Health Conditions During the COVID-19 Pandemic
Authors: Polina Krass, Evan Dalton, Stephanie K. Doupnik, Jeremy Esposito
Journal: JAMA Network Open (2021)

This cross-sectional study describes the changes in the demographic characteristics and clinical outcomes of pediatric emergency department (ED) visits for mental health conditions during the COVID-19 pandemic.