tbuckley/cabot-search huggingface dataset:
Effect of bio-control agents on yield, yield components and root rot control in two wheat cultivars at New Valley region, Egypt
Authors: M Y Moubarak, M F Abdel-Monaim
Journal: Journal of Clinical Oncology (2011)

The main aim of this study is to evaluate efficiency of four bioagents, Bacillus subtilis(isolate BSM1), Bacillus megaterium (isolate BMM5), Trichoderma viride (isolate TVM2) and Trichoderma harzianum (isolate THM4) for the control of rot pathogensFusarium graminearum, Drechslera halodes and Rhizoctonia solani on two wheat cultivars (Sakha 93 and Bani Suif 5) under greenhouse conditions. Moreover, their effect on wheat growth and yield were also studied under field conditions. In vitro, all tested bioagents significantly reduced redial growth of the pathogenic fungi. T. viridewas active more than the other tested bioagents followed by T. harzianum, while B. subtilis was the least ones. Under greenhouse conditions, all tested bioagents were able to reduce significantly damping-off and root rot caused by the tested pathogens compared with control and increased fresh and dry weight of the survival plants when applied as soil or grain treatments however, there was variation among bioagent isolates effect on reduction of disease severity both application methods. T. viride andB. megaterium were recorded the highest effective in this respect compared with other tested bioagents. Under field conditions, analysis of variance and mean performance were estimated for four characters: grain yield 4.8 m-2, No. of spikes m-2, No. of kernels spike-1 and 1000-kernel weight. Significant mean squares were obtained for all studied characters between the seasons (S), methods (M), (S) × (M), treatments (T), (S) × (T), (M) (T) and interaction (S) × (M) × (T) for Sakha 93 cultivar and Bani Suif 5 cultivars except application methods and (S) × (M) for number of kernels spike-1 and 1000-kernel weight, respectively. While the treatments T. harzianum and B. megaterium were best treatments to increase grain yield, the treatments B. subtilis and T. harzianum were best treatments to increase number of spikes and the treatments B. subtilis and B. megaterium were best treatments to increase number of kernels for  soil and grain application methods, respectively.

	 

	Key words:  Bio-agents, root rot disease, wheat growth, yield and yield components
STINGing Viral Tumors: What We Know from Head and Neck Cancers
Authors: Emma Saulters, John F. Woolley, Shankar Varadarajan, Terence M. Jones, Lekh N. Dahal
Journal: Cancer Research (2021)

Abstract It has now become increasingly clear that viruses, which may not be directly oncogenic, can affect the biology of tumors as well as immune behavior against tumors. This has led to a fundamental question: Should tumors associated with viral infection be considered distinct from those without? Typically, viruses activate the host innate immune responses by stimulating pathogen recognition receptors and DNA-sensing pathways, including the stimulator of interferon genes (STING) pathway. However, regulation of the STING pathway in a virus-associated tumor microenvironment is poorly understood. Human papillomavirus (HPV) infection within a subset of head and neck squamous cell carcinomas (HNSCC) promotes a unique etiology and clinical outcome. For reasons currently not well understood, patients with HPV+ tumors have a better outcome in terms of both overall survival and reduced risk of recurrence compared with HPV− HNSCC. This observation may reflect a greater intrinsic immunogenicity associated with HPV infection, pertaining to innate immune system pathways activated following recognition of viral nucleotides. Here we discuss how HNSCC provides a unique model to study the STING pathway in the context of viral-induced tumor type as well as recent advances in our understanding of this pathway in HSNCC.
Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts
Authors: Nick A Weaver, Hugo J Kuijf, Hugo P Aben, Jill Abrigo, Hee-Joon Bae, Mélanie Barbay, Jonathan G Best, Régis Bordet, Francesca M Chappell, Christopher P L H Chen, Thibaut Dondaine, Ruben S van der Giessen, Olivier Godefroy, Bibek Gyanwali, Olivia K L Hamilton, Saima Hilal, Irene M C Huenges Wajer, Yeonwook Kang, L Jaap Kappelle, Beom Joon Kim, Sebastian Köhler, Paul L M de Kort, Peter J Koudstaal, Gregory Kuchcinski, Bonnie Y K Lam, Byung-Chul Lee, Keon-Joo Lee, Jae-Sung Lim, Renaud Lopes, Stephen D J Makin, Anne-Marie Mendyk, Vincent C T Mok, Mi Sun Oh, Robert J van Oostenbrugge, Martine Roussel, Lin Shi, Julie Staals, Maria del C Valdés-Hernández, Narayanaswamy Venketasubramanian, Frans R J Verhey, Joanna M Wardlaw, David J Werring, Xu Xin, Kyung-Ho Yu, Martine J E van Zandvoort, Lei Zhao, J Matthijs Biesbroek, Geert Jan Biessels
Journal: The Lancet Neurology (2021)
PROGNOSTIC VALUE OF RIGHT VENTRICULAR REMODELING IN PATIENTS UNDERGOING CONCOMITANT AORTIC AND MITRAL VALVE SURGERY
Authors: Yi Kei Stephanie Tse, Yu Juan Yu, Hang Long Li, Mei Zhen Wu, Qing Wen Ren, Yan Chen, Shuk Yin Yu, Pui Fai Wong, Si Yeung Yu, Lok Yee Lam, Kwan Yu Li, Ka Lam Leung, Hung-Fat Tse, Kai Hang Yiu
Journal: Journal of the American College of Cardiology (2021)
SARS-CoV-2 vaccination responses in untreated, conventionally treated and anticytokine-treated patients with immune-mediated inflammatory diseases
Authors: David Simon, Koray Tascilar, Filippo Fagni, Gerhard Krönke, Arnd Kleyer, Christine Meder, Raja Atreya, Moritz Leppkes, Andreas E Kremer, Andreas Ramming, Milena L Pachowsky, Florian Schuch, Monika Ronneberger, Stefan Kleinert, Axel J Hueber, Karin Manger, Bernhard Manger, Carola Berking, Michael Sticherling, Markus F Neurath, Georg Schett
Journal: Annals of the Rheumatic Diseases (2021)

To better understand the factors that influence the humoral immune response to vaccination against SARS-CoV-2 in patients with immune-mediated inflammatory diseases (IMIDs).Patients and controls from a large COVID-19 study, with (1) no previous history of COVID-19, (2) negative baseline anti-SARS-CoV-2 IgG test and (3) SARS-CoV-2 vaccination at least 10 days before serum collection were measured for anti-SARS-CoV-2 IgG. Demographic, disease-specific and vaccination-specific data were recorded.Vaccination responses from 84 patients with IMID and 182 controls were analysed. While all controls developed anti-SARS-CoV-2 IgG, five patients with IMID failed to develop a response (p=0.003). Moreover, 99.5% of controls but only 90.5% of patients with IMID developed neutralising antibody activity (p=0.0008). Overall responses were delayed and reduced in patients (mean (SD): 6.47 (3.14)) compared with controls (9.36 (1.85); p<0.001). Estimated marginal means (95% CI) adjusted for age, sex and time from first vaccination to sampling were 8.48 (8.12-8.85) for controls and 6.90 (6.45-7.35) for IMIDs. Significantly reduced vaccination responses pertained to untreated, conventionally and anticytokine treated patients with IMID.Immune responses against the SARS-CoV-2 are delayed and reduced in patients with IMID. This effect is based on the disease itself rather than concomitant treatment.
びまん性大細胞型B細胞リンパ腫(DLBCL)における血清可溶性インターロイキン2受容体(sIL-2R)レベル:重要な予後因子
Authors: Nakamura S, Yokota A, Takagi T, Yoshino T, Niitsu N, Sawada U, Kodama F, Asaoku H, Kuraishi Y, Okamoto M, Yoshida T
Journal: Annals of Oncology (2000)
ZERO FLUOROSCOPY APPROACH VERSUS CONVENTIONAL FLUOROSCOPY APPROACH FOR CARDIAC ARRHYTHMIA ABLATION: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Chanavuth Kanitsoraphan, Chol Techorueangwiwat, Jakrin Kewcharoen, Pattara Rattanawong, Thomas Bunch, Leenhapong Navaravong
Journal: Journal of the American College of Cardiology (2021)
Difference in Survival Outcome of Primary Central Nervous System Lymphoma By Histologic Types
Authors: Dai Chihara, Nathan H. Fowler, Yasuhiro Oki, Michelle A. Fanale, Loretta Nastoupil, Jason R. Westin, Luis E. Fayad, Sattva S. Neelapu, Chan Yoon Cheah
Journal: Blood (2017)
SHORT-TERM CLINICAL OUTCOMES OF TRANSCATHETER TRICUSPID VALVE REPAIR WITH THE 3RD GENERATION MITRACLIP XTR SYSTEM
Authors: Tobias Friedrich Ruf, Rebecca Hahn, Andres Beiras-Fernandez, Felix Kreidel, Michaela Hell, Gerdes Patrick, Markus Vosseler, Martin Geyer, Alexander Tamm, Thomas Münzel, Ralph Stephan Von Bardeleben
Journal: Journal of the American College of Cardiology (2021)
Vaccine-induced ICOS+CD38+ circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways
Authors: Ramin Sedaghat Herati, Luisa Victoria Silva, Laura A. Vella, Alexander Muselman, Cecile Alanio, Bertram Bengsch, Raj K. Kurupati, Senthil Kannan, Sasikanth Manne, Andrew V. Kossenkov, David H. Canaday, Susan A. Doyle, Hildegund C.J. Ertl, Kenneth E. Schmader, E. John Wherry
Journal: Cell Reports Medicine (2021)
TEN-YEAR TRENDS IN PERCUTANEOUS BALLOON MITRAL VALVULOPLASTY COMPLICATIONS IN THE US - THE NATIONAL INPATIENT SAMPLE (2008-2017)
Authors: Trisha Slehria, Michael Hendrickson, Krishan Sivaraj, Sameer Arora, Michael Yeung, Matthew Cavender, John Vavalle
Journal: Journal of the American College of Cardiology (2021)
Securing a sustainable and fit-for-purpose UK health and care workforce
Authors: Michael Anderson, Ciaran O'Neill, Jill Macleod Clark, Andrew Street, Michael Woods, Charlotte Johnston-Webber, Anita Charlesworth, Moira Whyte, Margaret Foster, Azeem Majeed, Emma Pitchforth, Elias Mossialos, Miqdad Asaria, Alistair McGuire
Journal: The Lancet (2021)
Ponder of concern and long-term safety of infants from mothers with chronic hepatitis B treated with tenofovir disoproxil
Authors: Ankur Jindal, Ashish Vyas, Garima Dubey
Journal: Gut (2021)

We read with interest the important article by Pan CQ and colleagues, wherein they demonstrated the long-term safety of infants whose mothers were treated with tenofovir disoproxil fumarate (TDF) during pregnancy.1 However, we feel that the findings are not universally applicable and may not have an influence on clinical practice.

In this study, infants were exposed to TDF for a short median duration of 8.2 weeks. It is known that the adverse effects of TDF on bone mineral density …
EXOSOMES FROM HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES (ICMS) AND MESENCHYMAL STEM CELLS (MSCS) RECOVER HEART FUNCTION IN PORCINE ACUTE MYOCARDIAL INFARCTION (MI) MODEL
Authors: Nathan Bayardo, Connor O'Brien, Evgeniya Vaskova, Jennifer Lyons, Yuko Tada, Phillip Yang
Journal: Journal of the American College of Cardiology (2021)
EFFICACY AND SAFETY OF DIRECT ORAL ANTICOAGULANTS VERSUS LOW MOLECULAR WEIGHT HEPARIN IN CANCER ASSOCIATED VENOUS THROMBOEMBOLISM; A SYSTEMATIC REVIEW AND METAANALYSIS
Authors: Mohammed Mhanna, Pinang Shastri, Cameron Burmeister, Jermey C. Tomcho, Mitra M. Patel, Elzanaty M. Ahmed, Sapan Bhuta, Neha J. Patel, Omar Sajdeya, Sami Ghazaleh, Azizullah Beran
Journal: Journal of the American College of Cardiology (2021)
HEART FAILURE HOSPITALIZATION RATE REDUCTION DURING COVID-19 PANDEMIC
Authors: Andrea D’Amato, Paolo Severino, Andrea Saglietto, Fabrizio D’Ascenzo, Claudia Marini, Marco Schiavone, Nicolò Ghionzoli, Filippo Pirrotta, Francesca Troiano, Margherita Cannillo, Marco Mennuni, Andrea Rognoni, Francesco Rametta, Alessandro Galluzzo, Gianluca Agnes, Fabio Infusino, Mariateresa Pucci, Carlo Lavalle, Luca Cacciotti, Paul Mather, Walter Grosso Marra, Fabrizio Ugo, Giovanni Forleo, Maurizio Viecca, Nuccia Morici, Giuseppe Patti, Gaetano Maria De Ferrari, Alberto Palazzuoli, Massimo Mancone, Francesco Fedele
Journal: Journal of the American College of Cardiology (2021)
CARDIOVASCULAR COMPLICATIONS ASSOCIATED WITH NOVEL AGENTS IN THE CHRONIC LYMPHOCYTIC LEUKEMIA ARMAMENTARIUM
Authors: Udhayvir Grewal, Subhash Garikipati, Aakash Sheth, Shiva Jashwanth Gaddam, Sahith Thotamgari, Kavitha Beedupalli, Paari Dominic Swaminathan
Journal: Journal of the American College of Cardiology (2021)
Drug diffusivities in nanofibrillar cellulose hydrogel by combined time-resolved Raman and fluorescence spectroscopy
Authors: Jacopo Zini, Jere Kekkonen, Ville A. Kaikkonen, Timo Laaksonen, Pekka Keränen, Tuomo Talala, Anssi J. Mäkynen, Marjo Yliperttula, Ilkka Nissinen
Journal: Journal of Controlled Release (2021)

Hydrogels, natural and synthetic origin, are actively studied for their use for implants and payload carriers. These biomaterials for delivery systems have enormous potential in basic biomedical research, drug development, and long-term delivery of biologics. Nanofibrillated cellulose (NFC) hydrogels, both natural and anionic (ANFC) ones, allow drug loading for immediate and controlled release via the slow drug dissolution of solid drug crystals into hydrogel and its subsequent release. This property makes NFC originated hydrogels an interesting non-toxic and non-human origin material as drug reservoir for long-term controlled release formulation or implant for patient care. A compelling tool for studying NFC hydrogels is Raman spectroscopy, which enables to resolve the chemical structures of different molecules in a high-water content like hydrogels, since Raman spectroscopy is insensitive to water molecules. That offers real time investigation of label-free drugs and their release in high-water-content media. Despite the huge potential of Raman spectroscopy in bio-pharmaceutical applications, the strong fluorescence background of many drug samples masking the faint Raman signal has restricted the widespread use of it. In this study we used a Raman spectrometer capable of suppressing the unpleasant fluorescence background by combining a pulsed laser and time-resolved complementary metal-oxide-semiconductor (CMOS) single-photon avalanche diode (SPAD) line sensor for the label-free investigation of Metronidazole and Vitamin C diffusivities in ANFC. The results show the possibility to modulate the ANFC-based implants and drug delivery systems, when the release rate needs to be set to a desired value. More importantly, the now developed label free real-time method is universal and can be adapted to any hydrogel/drug combination for producing reliable drug diffusion coefficient data in complex and heterogeneous systems, where traditional sampling-based methods are cumbersome to use. The wide temporal range of the time-resolved CMOS SPAD sensors makes it possible to capture also the fluorescence decay of samples, giving rise to a combined time-resolved Raman and fluorescence spectroscopy, which provides additional information on the chemical, functional and structural changes in samples.
COMMUNITY-CENTRIC STUDY TO MITIGATE CARDIOVASCULAR DISEASE IN RURAL NEPAL: THE NON-COMMUNICABLE DISEASE IN NEPAL STUDY
Authors: Gagan Neupane, Sameer Acharya, Ada Thapa, Sudim Sharma, Shatakshi Pokharel, Manoj Bhattarai, Ashish Upadhyay, Nona Sotoodehnia, Biraj Karmacharya, Lava Timsina, Yashashwi Pokharel
Journal: Journal of the American College of Cardiology (2021)
Sociodemographic factors and uncomplicated cystitis in women aged 15–50 years: a nationwide Swedish cohort registry study (1997–2018)
Authors: Filip Jansåker, Xinjun Li, Kristina Sundquist
Journal: The Lancet Regional Health - Europe (2021)

Symptoms suggestive of uncomplicated cystitis constitutes one of the most common reasons to seek health care in otherwise healthy women. Previous studies regarding the relationship between sociodemographic factors and uncomplicated cystitis are limited, mainly because of the lack of nationwide population-based data from primary healthcare settings, where most uncomplicated cystitis are diagnosed.A Swedish nation-wide open cohort study consisting of 2 044 065 females who were 15-50 years of age during the study period (1997-2018) was conducted. The outcome was first event uncomplicated cystitis diagnosed in primary health care rather than an assessment of the "true" incidence, which is not feasible in nationwide datasets. Cox regression models were used in the statistical analyses.The study identified 546 076 first events of uncomplicated cystitis (26•7% of the study population), corresponding to an incidence rate per 100 person-years of 2•91 (95% CI 2•90-2•91). In fully adjusted models, rural living was associated with lower risks of uncomplicated cystitis (Hazard ratio, HR, 0•67; 95% CI, 0•66-0•68) compared to urban living, while both Middle Eastern/North African (HR, 1•15; 95% CI, 1•14-1•16) and Latin American/Caribbean (HR, 1•24; 95% CI, 1•22-1•27) women had higher risks compared to Swedish women. Low education and low income were also associated with higher risks compared to high education and high income.This study presents novel risk factors associated with uncomplicated cystitis in women. The findings may help health care workers in the treatment of women with symptoms of uncomplicated cystitis.The Primary Healthcare Management and ALF funding (Region Skåne, Sweden) and the Swedish Research Council.
IMPACT OF DIABETES MELLITUS ON CLINICAL OUTCOMES OF PATIENTS WITH NATIVE VALVE INFECTIVE ENDOCARDITIS
Authors: Gabrielle de Allie, Temidayo Abe, Mtanis Khoury, Harry Onoriode Eyituoyo, Ndausung Udongwo, Valery Effoe, Titilope Olanipekun, Paul Mather
Journal: Journal of the American College of Cardiology (2021)
Remote management of covid-19: we could do more, more widely
Authors: Andrew J Ashworth
Journal: BMJ (2021)

Greenhalgh and colleagues’ useful guidance1 on the remote management of covid-19 using home pulse oximetry and virtual ward support might further be improved by embracing new technology and thinking.

Provision of suitable pulse oximeters to patients in their homes could easily be organised with a firm such as Amazon (decent negotiators would organise a no-profit arrangement with …
INCIDENCE, PREDICTOR AND CLINICAL OUTCOMES OF MULTIPLE RESHEATHING WITH SELF-EXPANDING VALVES DURING TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Fernando Bernardi, Josep Rodés-Cabau, Gabriela Tirado-Conte, Ignacio Amat Santos, Claudia Plachtzik, Fernando Cura, Matias Sztejfman, Fernanda Mangione, Rogerio Tumeleiro, Vinícius Esteves, Eduardo Pessoa de Mello, Alejandro Chauvet, Felipe Fuchs, Rogerio Sarmento-Leite, Estevão Martins, Luis Nombela-Franco, José Raul Delgado-Arana, Wolfgang Bocksch, Pablo Lamelas, Carlos Giuliani, Salvador Cristóvão, Diego Carter Campanha-Borges, Fábio Sândoli de Brito, Alexandre Abizaid, Henrique Ribeiro
Journal: Journal of the American College of Cardiology (2021)
Association of Drug Rebates and Competition With Out-of-Pocket Coinsurance in Medicare Part D, 2014 to 2018
Authors: Darius Lakdawalla, Meng Li
Journal: JAMA Network Open (2021)

<h3>Importance</h3> Prior research has documented the increase in prescription drug rebates and the coincident increase in out-of-pocket burden for patients paying coinsurance tied to list prices. <h3>Objective</h3> To describe the out-of-pocket burden on patients with coinsurance and assess its association with pharmaceutical competition, which increases payers' leverage to seek higher rebates. <h3>Design, Setting, and Participants</h3> This retrospective cohort study used branded prescription drugs with US sales reported by publicly traded companies. The study included drugs with nonmissing, nonnegative rebates between 2014 and 2018 from SSR Health. Data analysis was conducted from June to December 2020. <h3>Exposures</h3> Level of branded and generic competition and calendar year. <h3>Main Outcomes and Measures</h3> Retail price markup (ie, the ratio of rebate to net price) paid by patients at the point of sale and effective out-of-pocket share (ie, coinsurance multiplied by list price divided by net price) of a standard Part D plan. Trends in these outcomes were examined and then stratified by degree of competition. <h3>Results</h3> There were 3322 unique National Drug Codes in the analysis, representing 232 distinct molecules from 138 therapeutic classes in 34 disease areas. The ratio of rebate to net prices was higher and increased faster for drugs with branded and generic competitors (from 83% to 172%) than for drugs with only branded competitors (from 61% to 115%) and those without generic equivalents (from 33% to 49%). Hypothetical patients paying standard Part D coinsurance on drug list prices would have experienced an effective out-of-pocket share increase from 48% to 64% in the initial coverage phase, and from 10% to 13% in the catastrophic coverage phase between 2014 and 2018. In the coverage gap, the share increased from 92% in 2014 to 98% in 2016 and then decreased to 90% in 2018. Compared with drugs with no competition, effective out-of-pocket share paid by patients grew 50% faster for drugs with branded competitors and 100% faster for those with branded and generic competitors. <h3>Conclusions and Relevance</h3> This study found substantial increases in cost-sharing burden for patients paying coinsurance on drug list prices between 2014 and 2018, especially in markets with more pharmaceutical competition. Payers passing rebates through to patients at the point of sale could restore the benefits of competition and rebates.
Patient profiling in heart failure for tailoring medical therapy. A consensus document of the <scp>Heart Failure Association of the European Society of Cardiology</scp>
Authors: Giuseppe M.C. Rosano, Brenda Moura, Marco Metra, Michael Böhm, Johann Bauersachs, Tuvia Ben Gal, Stamatis Adamopoulos, Magdy Abdelhamid, Vasiliki Bistola, Jelena Čelutkienė, Ovidiu Chioncel, Dimitrios Farmakis, Roberto Ferrari, Gerasimos Filippatos, Loreena Hill, Ewa A. Jankowska, Tiny Jaarsma, Pardeep Jhund, Mitja Lainscak, Yuri Lopatin, Lars H. Lund, Davor Milicic, Wilfried Mullens, Fausto Pinto, Piotr Ponikowski, Gianluigi Savarese, Thomas Thum, Maurizio Volterrani, Stefan D. Anker, Petar M. Seferovic, Andrew J.S. Coats
Journal: European Journal of Heart Failure (2021)
RISK ASSESSMENT OF EMERGENCY DEPARTMENT PATIENTS WITH HIGH SENSITIVITY CARDIAC TROPONIN I CONCENTRATIONS BELOW THE 99TH PERCENTILE SEX-SPECIFIC UPPER REFERENCE LIMITS
Authors: Fred S. Apple, Yader Sandoval, Richard Nowak, Christopher DeFilippi, Robert Christenson, W. Frank Peacock, James McCord, Alexander Limkakeng, Karen Schulz
Journal: Journal of the American College of Cardiology (2021)
SURFACE ECG-BASED MACHINE LEARNING MODEL FOR PREDICTING PATIENT SUBGROUP AT A HIGH RISK FOR MAJOR ADVERSE CARDIAC EVENTS
Authors: Heenaben Patel, Naveena Yanamala, Marton Tokodi, Nobuyaki Kagiyama, Marco Piccirilli, Sirish Shrestha, Peter Farjo, Grace Casaclang-Verzosa, Wadea Tarhuni, Negin Nezarat, Matthew Budoff, Jagat Narula, Partho Sengupta
Journal: Journal of the American College of Cardiology (2021)
An artificial intelligence‐assisted diagnostic platform for rapid near‐patient hematology
Authors: Neta Bachar, Dana Benbassat, David Brailovsky, Yochay Eshel, Dan Glück, Daniel Levner, Sarah Levy, Sharon Pecker, Evgeny Yurkovsky, Amir Zait, Cordelia Sever, Alexander Kratz, Carlo Brugnara
Journal: American Journal of Hematology (2021)

Abstract Hematology analyzers capable of performing complete blood count (CBC) have lagged in their prevalence at the point‐of‐care. Sight OLO (Sight Diagnostics, Israel) is a novel hematological platform which provides a 19‐parameter, five‐part differential CBC, and is designed to address the limitations in current point‐of‐care hematology analyzers using recent advances in artificial intelligence (AI) and computer vision. Accuracy, repeatability, and flagging capabilities of OLO were compared with the Sysmex XN‐Series System (Sysmex, Japan). Matrix studies compared performance using venous, capillary and direct‐from‐fingerprick blood samples. Regression analysis shows strong concordance between OLO and the Sysmex XN, demonstrating that OLO performs with high accuracy for all CBC parameters. High repeatability and reproducibility were demonstrated for most of the testing parameters. The analytical performance of the OLO hematology analyzer was validated in a multicenter clinical laboratory setting, demonstrating its accuracy and comparability to clinical laboratory‐based hematology analyzers. Furthermore, the study demonstrated the validity of CBC analysis of samples collected directly from fingerpricks.