tbuckley/cabot-search huggingface dataset:
The Management of Substance Use Disorders: Synopsis of the 2021 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline
Authors: Christopher Perry, Joseph Liberto, Charles Milliken, Jennifer Burden, Hildi Hagedorn, Timothy Atkinson, James R. McKay, Larissa Mooney, James Sall, Comilla Sasson, Andrew Saxon, Christopher Spevak, Adam J. Gordon, Christopher Perry, Joseph Liberto, Charles Milliken, Jennifer Burden, Hildi Hagedorn, Timothy Atkinson, James R. McKay, Larissa Mooney, James Sall, Comilla Sasson, Andrew Saxon, Christopher Spevak, Adam J. Gordon, Renee Redden, Rachael Coller, Kathleen Stack, Christopher Taylor, Fran Murphy, Jim Smirniotopoulos
Journal: Annals of Internal Medicine (2022)

Description: In August 2021, leadership within the U.S. Department of Veterans Affairs (VA) and U.S. Department of Defense (DoD) approved a joint clinical practice guideline (CPG) for the management of substance use disorders (SUDs). This synopsis summarizes key recommendations. Methods: In March 2020, the VA/DoD Evidence-Based Practice Work Group assembled a team to update the 2015 VA/DoD Clinical Practice Guideline for the Management of Substance Use Disorders that included clinical stakeholders and conformed to the National Academy of Medicine's tenets for trustworthy CPGs. The guideline panel developed key questions, systematically searched and evaluated the literature, created two 1-page algorithms, and distilled 35 recommendations for care using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) system. This synopsis presents the recommendations that were believed to be the most clinically impactful. Recommendations: The scope of the CPG is broad; however, this synopsis focuses on key recommendations for the management of alcohol use disorder, use of buprenorphine in opioid use disorder, contingency management, and use of technology and telehealth to manage patients remotely.
THE FUTURE OF EDUCATION IN INTERVENTIONAL CARDIOLOGY: DEVELOPMENT AND UTILIZATION OF A NOVEL APP-BASED EDUCATIONAL PLATFORM
Authors: Anoop Ninan Koshy, Htoo Kyaw, Ali Farooq, Andriy Vengrenyuk, Joseph M. Sweeny, Parasuram Krishnamoorthy, Sahil Khera, Nitin Barman, Gilbert Hin-Lung Tang, Jagat Narula, Samin K. Sharma, Annapoorna Subhash Kini
Journal: Journal of the American College of Cardiology (2022)
IATROGENIC AORTIC DISSECTION: EXPANDED INSIGHTS FROM THE INTERNATIONAL REGISTRY OF ACUTE AORTIC DISSECTION
Authors: Kevin M. Harris, Kristen M. Westenfield, Neil Parikh, Thomas G. Gleason, Marc Schermerhorn, Maral Ouzounian, Arturo Evangelista, Joseph S. Coselli, Chih-Wen Pai, Marek Ehrlich, Clayton Allen Kaiser, Valerio Tolva, Marco Di Eusanio, Ibrahim Sultan, Kim A. Eagle, Himanshu J. Patel
Journal: Journal of the American College of Cardiology (2022)
SUCCESSFUL ALCOHOL SEPTAL ABLATION FOR DYNAMIC COLLAPSE FOLLOWING TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Yusuke Kobari, Yuta Konami, Shingo Sakata, Shohei Imaeda, Toshinobu Ryuzaki, Sosuke Myojin, Taku Inohara, Hikaru Tsuruta, Takahide Arai, Kentaro Hayashida, Keiichi Fukuda
Journal: Journal of the American College of Cardiology (2022)
Long-Term Longitudinal Patterns of Patient-Reported Fatigue After Breast Cancer: A Group-Based Trajectory Analysis
Authors: Ines Vaz-Luis, Antonio Di Meglio, Julie Havas, Mayssam El-Mouhebb, Pietro Lapidari, Daniele Presti, Davide Soldato, Barbara Pistilli, Agnes Dumas, Gwenn Menvielle, Cecile Charles, Sibille Everhard, Anne-Laure Martin, Paul H. Cottu, Florence Lerebours, Charles Coutant, Sarah Dauchy, Suzette Delaloge, Nancy U. Lin, Patricia A. Ganz, Ann H. Partridge, Fabrice André, Stefan Michiels
Journal: Journal of Clinical Oncology (2022)

PURPOSE Fatigue is recognized as one of the most burdensome and long-lasting adverse effects of cancer and cancer treatment. We aimed to characterize long-term fatigue trajectories among breast cancer survivors. METHODS We performed a detailed longitudinal analysis of fatigue using a large ongoing national prospective clinical study (CANcer TOxicity, ClinicalTrials.gov identifier: NCT01993498 ) of patients with stage I-III breast cancer treated from 2012 to 2015. Fatigue was assessed at diagnosis and year 1, 2, and 4 postdiagnosis. Baseline clinical, sociodemographic, behavioral, tumor-related, and treatment-related characteristics were available. Trajectories of fatigue and risk factors of trajectory-group membership were identified by iterative estimates of group-based trajectory models. RESULTS Three trajectory groups were identified for severe global fatigue (n = 4,173). Twenty-one percent of patients were in the high-risk group, having risk estimates of severe global fatigue of 94.8% (95% CI, 86.6 to 100.0) at diagnosis and 64.6% (95% CI, 59.2 to 70.1) at year 4; 19% of patients clustered in the deteriorating group with risk estimates of severe global fatigue of 13.8% (95% CI, 6.7 to 20.9) at diagnosis and 64.5% (95% CI, 57.3 to 71.8) at year 4; 60% were in the low-risk group with risk estimates of 3.6% (95% CI, 2.5 to 4.7) at diagnosis and 9.6% (95% CI, 7.5 to 11.7) at year 4. The distinct dimensions of fatigue clustered in different trajectory groups than those identified by severe global fatigue, being differentially affected by sociodemographic, clinical, and treatment-related factors. CONCLUSION Our findings highlight the multidimensional nature of cancer-related fatigue and the complexity of its risk factors. This study helps to identify patients with increased risk of severe fatigue and to inform personalized interventions to ameliorate this problem.
Social determinants of the changing tuberculosis prevalence in Việt Nam: Analysis of population-level cross-sectional studies
Authors: Nicola Foster, Hai V. Nguyen, Nhung V. Nguyen, Hoa B. Nguyen, Edine W. Tiemersma, Frank G. J. Cobelens, Matthew Quaife, Rein M. G. J. Houben
Journal: PLoS Medicine (2022)

Background An ecological relationship between economic development and reduction in tuberculosis prevalence has been observed. Between 2007 and 2017, Việt Nam experienced rapid economic development with equitable distribution of resources and a 37% reduction in tuberculosis prevalence. Analysing consecutive prevalence surveys, we examined how the reduction in tuberculosis (and subclinical tuberculosis) prevalence was concentrated between socioeconomic groups. Methods and findings We combined data from 2 nationally representative Việt Nam tuberculosis prevalence surveys with provincial-level measures of poverty. Data from 94,156 (2007) and 61,763 (2017) individuals were included. Of people with microbiologically confirmed tuberculosis, 21.6% (47/218) in 2007 and 29.0% (36/124) in 2017 had subclinical disease. We constructed an asset index using principal component analysis of consumption data. An illness concentration index was estimated to measure socioeconomic position inequality in tuberculosis prevalence. The illness concentration index changed from −0.10 (95% CI −0.08, −0.16; p = 0.003) in 2007 to 0.07 (95% CI 0.06, 0.18; p = 0.158) in 2017, indicating that tuberculosis was concentrated among the poorest households in 2007, with a shift towards more equal distribution between rich and poor households in 2017. This finding was similar for subclinical tuberculosis. We fitted multilevel models to investigate relationships between change in tuberculosis prevalence, individual risks, household socioeconomic position, and neighbourhood poverty. Controlling for provincial poverty level reduced the difference in prevalence, suggesting that changes in neighbourhood poverty contribute to the explanation of change in tuberculosis prevalence. A limitation of our study is that while tuberculosis prevalence surveys are valuable for understanding socioeconomic differences in tuberculosis prevalence in countries, given that tuberculosis is a relatively rare disease in the population studied, there is limited power to explore socioeconomic drivers. However, combining repeated cross-sectional surveys with provincial deprivation estimates during a period of remarkable economic growth provides valuable insights into the dynamics of the relationship between tuberculosis and economic development in Việt Nam. Conclusions We found that with equitable economic growth and a reduction in tuberculosis burden, tuberculosis became less concentrated among the poor in Việt Nam.
WHOM TO BELIEVE? POSITRON EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY AND NEAR-INFRARED SPECTROSCOPY INTRAVASCULAR ULTRASOUND IMAGING IN VULNERABLE CORONARY PLAQUE DETECTION
Authors: Maris Lapšovs, Karlis Trusinskis, Marika Kalnina, Laima Caunite, Evija Knoka, Mairita Karantajere, Rudolfs Roze, Andrejs Erglis, Pauls Stradiņš
Journal: Journal of the American College of Cardiology (2022)
PROGNOSTIC SIGNIFICANCE OF PROXIMAL INVOLVEMENT CAC IN ASYMPTOMATIC PATIENTS: FROM EISNER TRIAL
Authors: Ramyashree Tummala, Donghee Han, Aryabod Razipour, Sean W. Hayes, Louise Thomson, John D. Friedman, Piotr Slomka, Alan Rozanski, Damini Dey, Daniel S. Berman
Journal: Journal of the American College of Cardiology (2022)
Training and Practice Characteristics of International Medical Graduates in Dermatology
Authors: Vijay Kodumudi, Jeffrey M. Cohen, Hao Feng
Journal: JAMA Dermatology (2022)

often easily recognizable at first glance, even for individuals with less experience, and they can be extremely useful in daily clinical practice.A limitation of this study is that it was a single-center study with a limited number of cases and controls.More extensive studies are required to determine the sensitivity and specificity of the ñ sign as well as its predictive values.In this qualitative study, we propose the ñ sign as a visual clue for the histopathologic diagnosis of psoriasis based on the sum of 2 well-characterized histologic criteria.These findings are not specific to psoriasis and can be observed separately in other inflammatory skin conditions such as pityriasis lichenoides or subacute eczema. 1,6 However, the sum of both criteria (ie, the ñ sign) is a distinctive histologic finding of psoriasis.In conclusion, the ñ sign may be a useful mnemonic device for dermatology and pathology residents and even for experienced physicians in distinguishing between psoriasis and other inflammatory skin disorders.
USE AND BENEFIT OF ANGIOTENSIN RECEPTOR NEPRILYSIN INHIBITORS IN SENIOR PATIENTS WITH LEFT VENTRICULAR SYSTOLIC DYSFUNCTION
Authors: Marcelino Cortes, Jose Maria Romero, Jose Antonio Esteban, Nieto Luis, Martinez Juan, Mikel Taibo, Rodriguez Carlos, Balaguer Jorge, Ana Maria Pello, Franco Juan Antonio, Tunon Jose
Journal: Journal of the American College of Cardiology (2022)
Diagnosis and Management of Acute Appendicitis
Authors: David A. Talan
Journal: JAMA (2022)

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IMPELLA VERSUS EXTRA-CORPOREAL MEMBRANE OXYGENATION SUPPORT IN CARDIOGENIC SHOCK: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Waiel Abusnina, Mahmoud Ismayl, Emily Peterson, Qais Radaideh, Abdelrazeg Houssein, Khagendra B. Dahal
Journal: Journal of the American College of Cardiology (2022)
External Validation of the Revised Pretransplant Assessment of Mortality Score in Allogeneic Hematopoietic Cell Transplantation: A Cohort Study
Authors: Nicolas Fattinger, Jan A. Roth, Helen Baldomero, Daiana Stolz, Michael Medinger, Dominik Heim, Michael Tamm, Jörg P. Halter, Jakob R. Passweg, Martina Kleber
Journal: HemaSphere (2022)

Pretransplant risk scores such as the revised Pretransplant Assessment of Mortality (rPAM) score help to predict outcome of patients receiving allogeneic hematopoietic cell transplantation (allo-HCT). Since the rPAM has not been validated externally in a heterogeneous patient population with different diseases, we aimed to validate the rPAM score in a real-world cohort of allo-HCT patients. A total of 429 patients were included receiving their first allo-HCT from 2008 to 2015. The predictive capacity of the rPAM score for 4-year overall survival (OS), nonrelapse mortality (NRM), and cumulative incidence of relapse (CIR) after allo-HCT was evaluated. Moreover, we evaluated the impact of the rPAM score for OS and used uni- and multivariable analyses to identify patient- and transplant-related predictors for OS. In rPAM score categories of <17, 17-23, 24-30, and >30, the OS probability at 4 years differed significantly with 61%, 36%, 26%, and 10%, respectively (P < 0.0001). In contrast to CIR, the NRM increased significantly in patients with higher rPAM scores (P < 0.001). Regarding the OS, the rPAM score had an area under the receiver operating characteristics curve of 0.676 (95% confidence interval [CI], 0.625-0.727) at 4 years. In the multivariable analysis, the rPAM score was associated with OS-independently of conditioning regimens (adjusted hazard ratio per 1-unit increase, 1.10; 95% CI, 1.06-1.10; P < 0.001). Additionally, forced expiratory volume in 1 second and the disease risk index were the components of the rPAM significantly associated with outcome. In our large real-world cohort with extended follow-up, the rPAM score was validated as an independent predictor of OS in patients with hematologic disorders undergoing allo-HCT.
Covid-19: Campaigners accuse Pfizer of blocking access to antiviral for trials in poorer countries
Authors: Jacqui Thornton
Journal: BMJ (2022)

Covid-19: Campaigners accuse Pfizer of blocking access to antiviral for trials in poorer countries Jacqui ThorntonPfizer has been accused of blocking "urgently needed" studies into the use of its novel oral antiviral drug for covid-19 combined with other medicines for use in low and middle income countries.
Association of pre-existing drug allergies with cutaneous immune-related adverse events among patients on immune checkpoint inhibitor therapy
Authors: Ted V. Jacoby, Tracey S. Otto, Maria S. Asdourian, Nishi Shah, Mara Farcasanu, Michael S. Chang, Leah L. Thompson, Kerry L. Reynolds, Steven T. Chen
Journal: British Journal of Dermatology (2022)

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Tri‐Layered and Gel‐Like Nanofibrous Scaffolds with Anisotropic Features for Engineering Heart Valve Leaflets
Authors: Shaohua Wu, Yiran Li, Caidan Zhang, Litao Tao, Mitchell Kuss, Jung Yul Lim, Jonathan Butcher, Bin Duan
Journal: Advanced Healthcare Materials (2022)

3D heterogeneous and anisotropic scaffolds that approximate native heart valve tissues are indispensable for the successful construction of tissue engineered heart valves (TEHVs). In this study, novel tri-layered and gel-like nanofibrous scaffolds, consisting of poly(lactic-co-glycolic) acid (PLGA) and poly(aspartic acid) (PASP), are fabricated by a combination of positive/negative conjugate electrospinning and bioactive hydrogel post-processing. The nanofibrous PLGA-PASP scaffolds present tri-layered structures, resulting in anisotropic mechanical properties that are comparable with native heart valve leaflets. Biological tests show that nanofibrous PLGA-PASP scaffolds with high PASP ratios significantly promote the proliferation and collagen and glycosaminoglycans (GAGs) secretions of human aortic valvular interstitial cells (HAVICs), compared to PLGA scaffolds. Importantly, the nanofibrous PLGA-PASP scaffolds are found to effectively inhibit the osteogenic differentiation of HAVICs. Two types of porcine VICs, from young and adult age groups, are further seeded onto the PLGA-PASP scaffolds. The adult VICs secrete higher amounts of collagens and GAGs and undergo a significantly higher level of osteogenic differentiation than young VICs. RNA sequencing analysis indicates that age has a pivotal effect on the VIC behaviors. This study provides important guidance and a reference for the design and development of 3D tri-layered, gel-like nanofibrous PLGA-PASP scaffolds for TEHV applications.
A CASE REPORT OF TRANSCATHETER MITRAL VALVE CLIP THERAPY IN PATIENT WITH CARDIOGENIC SHOCK DUE TO SEVERE ACUTE MITRAL REGURGITATION
Authors: Jiandong Preference Zhang, Ryan Orgel, Grayson Eubanks, Darryl A. Kalil, John Paul Vavalle, Matthew Aaron Cavender, George A. Stouffer
Journal: Journal of the American College of Cardiology (2022)
Pre- and post-COVID practice of interventional pulmonology in adults in Portugal
Authors: F. Guedes, A.J. Ferreira, J. Dionísio, L.V. Rodrigues, A. Bugalho
Journal: Pulmonology (2022)

There is a lack of information regarding bronchoscopy practice in adults in Portugal. Our objective was to obtain an overview of the characteristics, resources, techniques and behaviors in national interventional pulmonology (IP) units, before and after SARS-CoV-2 outbreak. An online survey was developed by an expert panel with a total of 46 questions comprising the specifications of each unit, namely physical space, equipment, staff, procedure planning, monitoring, technical differentiation, and numbers pre- and post-COVID-19. Forty-one interventional pulmonology centers were invited to participate between April and May 2021. 37 units (90.2%) responded to the survey. The majority (64.9%) have a fully dedicated space with a weekly presence of ≥3 chest physicians (82.1%) and support of an anesthesiologist on specific days (48.6%). There is marked heterogeneity in the IP unit's equipment, and 56.8% acquired disposable bronchoscopes after COVID-19 pandemics. Pre-bronchoscopy hemogram, platelet count and coagulation tests are regularly asked by more than 90% of the units, even when deep sedation or biopsies are not planned. In 97.3% of cases, topical anesthesia and midazolam are utilized. Propofol (21.6%) and fentanyl (29.7%) are occasionally employed in some institutions. Most units use ancillary sampling techniques to diagnose central or peripheral lesions, with radial EBUS being used for guidance of distal procedures in 37.8% of centers, linear EBUS and EUS-B-FNA for mediastinal diagnosis and/or staging in 45.9% and 27.0% of units, respectively. Cryobiopsies are used by 21.6% of respondents to diagnose diffuse lung diseases. Rigid bronchoscopy is performed in 37.8% of centers. There was a decrease in the number of flexible (p < 0.001) and rigid (p = 0.005) bronchoscopies and an upscale of personal protective equipment (PPE) during the COVID-19 outbreak. IP units have variable bronchoscopic practices, but during the COVID-19 pandemic, they complied with most international recommendations, as elective procedures were postponed and PPE levels increased.
UPDATED WILKINS SCORE BETTER PREDICTS PROCEDURAL SUCCESS OF PERCUTANEOUS BALLOON MITRAL VALVULOPLASTY IN RHEUMATIC MITRAL STENOSIS
Authors: Ply Chichareon, Thanapon Nilmoje, Saranyou Suwanugsorn, Noppadol Chamnarnphol, Treechada Wisaratapong, Sirichai Cheewatanakornkul, Sunti Limumpornpetch, Metus Thungthienthong, Watchara Lohawijarn, Woravut Jintapakorn
Journal: Journal of the American College of Cardiology (2022)
Receipt of Early Intervention Services Before Age 3 Years and Performance on Third-Grade Standardized Tests Among Children Exposed to Lead
Authors: Jeanette A. Stingone, Slavenka Sedlar, Sungwoo Lim, Katharine H. McVeigh
Journal: JAMA Pediatrics (2022)

<h3>Importance</h3> Research has shown that early intervention programs can improve academic outcomes of children with developmental delays. It has been suggested that similar programs may combat the deleterious effects of lead on children's neurodevelopment. However, to our knowledge, there are no published studies examining this possibility. <h3>Objective</h3> The objective of this study was to estimate the association between receipt of early intervention services and third-grade standardized test scores among children exposed to lead before age 3 years. <h3>Design, Setting, and Participants</h3> Cohort study including children born in New York City, New York, from 1994 to 1998 within an administrative data linkage of birth, lead monitoring, early intervention, and education data systems. Participants had a blood lead level of 4 μg/dL or greater at any point before age 3 years and later attended public school in New York City. <h3>Exposures</h3> Any use of early intervention services from birth through age 3 years. <h3>Main Outcomes and Measures</h3> Children who did or did not receive early intervention services were matched using propensity scores. Linear and log-binomial regression were used to estimate the association between receipt of early intervention services before age 3 years and standardized test scores in math and English-language arts in third grade. <h3>Results</h3> There were 2986 children exposed to lead who received early intervention services before age 36 months. Of these children, 2757 were propensity score–matched to 8160 children who did not receive services. Children who received early intervention services did 7% (95% CI, 3%-12%) of an SD better on math and 10% (95% CI, 5%-14%) of an SD better on English-language arts tests than children who did not receive services. In addition, children who received services were 14% (95% CI, 9%-19%) and 16% (95% CI, 9%-23%) more likely to meet test-based standards in math and English-language arts, respectively, than children who did not receive services. These associations became larger in magnitude when analyses were restricted to children with higher blood lead levels. <h3>Conclusions and Relevance</h3> By leveraging existing public health data, this study found evidence that receipt of early intervention services may benefit the academic performance of children exposed to lead early in life.
LIPOPROTEIN(A) AND THE RISK FOR ATHEROSCLEROTIC CARDIOVASCULAR EVENTS AMONG ADULTS WITH CHRONIC KIDNEY DISEASE AND A HISTORY OF ATHEROSCLEROTIC CARDIOVASCULAR DISEASE
Authors: Bharat Poudel, Robert S. Rosenson, Shia Kent, Vera Bittner, Orlando Gutierrez, Amanda H. Anderson, Mark Woodward, Elizabeth A. Jackson, Keri L. Monda, Archna Bajaj, Lei Huang, Daniel J. Rader, Mayank Kansal, Mahboob Rahman, Jiang He, Paul Muntner
Journal: Journal of the American College of Cardiology (2022)
AN AGGRESSIVE CASE OF NATIVE MITRAL VALVE ENDOCARDITIS
Authors: Alejandro Sanchez Nadales, Muftawu-Deen Iddrisu, Alejandra Diaz-Sierra, Antonio Lewis, Jose Sleiman, Abdullah Sarkar, Andres Sanchez Nadales, Dipan Uppal, Manojna Nimmagadda, Diana Miranda, Craig R. Asher
Journal: Journal of the American College of Cardiology (2022)