tbuckley/cabot-search huggingface dataset:
Abstract MP19: Academic-community Partnership To Evaluate The Effectiveness Of The Greater Boston Food Bank’s Healthy Pantry Program
Authors: Jenny Jia, Rachel Caty, Lauren Fiechtner, Rachel Zack, Anne N Thorndike
Journal: Circulation (2021)

Background: Food pantries are a significant nutrition source for food-insecure households. Traffic-light labeling is a new strategy in some pantries to help clients and staff identify healthier food choices. Healthy Pantry Program (HPP) is an online training designed by The Greater Boston Food Bank (GBFB) to teach staff of its affiliated pantries how to promote healthier choices by implementing traffic-light labels using Supporting Wellness at Pantries and behavioral nudges, such as placing healthy foods at eye level. Our academic research team partnered with GBFB to evaluate HPP by assessing if food pantries that participated in HPP increased their GBFB purchases of healthier (green and yellow) foods more than matched control pantries. Methods: We conducted an observational study of 107 food pantries in the GBFB network in eastern Massachusetts, including 10 pantries that completed HPP training and 97 control pantries matched by organizational characteristics and baseline food purchases. Five HPP pantries participated during Wave 1 (Oct 2018-Jan 2019), and 5 participated during Wave 2 (May 2019-Aug 2019). Outcomes were changes in percentage of pantries’ monthly green and yellow purchases from GBFB at 6-month (Waves 1 and 2) and 12-month (Wave 1 only) follow-ups compared to baseline purchases (6 months pre-HPP). We used a difference-in-differences analysis to examine whether HPP pantries increased green-yellow food purchases more than control pantries. Results: In Wave 1, HPP pantries had small but nonsignificant increases in green-yellow purchases at 6 and 12 months compared to matched controls (Table). In Wave 2, HPP and control pantries had similar increases in green-yellow purchases at 6 months. Conclusions: An online training implemented by a food bank to improve healthy choices in food pantries did not significantly improve pantries’ purchases of healthier foods. Academic-community organization partnerships to evaluate health promotion initiatives can help guide effective program design and development.
Abstract 15534: Fully Automated "Hands-off" Evaluation of Left Atrial Volume in Children
Authors: Hunter Kauffman, Kevin K Whitehead, Michael Convery, Matthew J O’Connor, Michael Quartermain, Anirban Banerjee
Journal: Circulation (2020)

Introduction: Three-dimensional echocardiography (3DE) has been shown to be superior to two-dimensional echocardiography (2DE) for the quantification of chamber volumes and dimensions. However, the utility of 3DE in routine clinical practice has been restricted by time-consuming analysis and the need for 3D-specific training. This study aims to assess the accuracy and clinical utility of Philips Dynamic Heart ModelA.I. (DHM), a “hands off” automated software program, that may be used to measure LA chamber dimensions. This is notable, as indexed LA volume has been used as a predictor of heart failure in adults. Hypothesis: We hypothesize that DHM will be able to quickly and accurately calculate left atrial chamber volume when compared to Cardiac MRI (CMRI) used as a gold standard. Methods: To date, 10 patients (Average Age 14.8±1.9) have undergone clinically indicated CMRI, immediately followed by 3DE, at the Children’s Hospital of Philadelphia. 3D images were analyzed via DHM without manual editing (hands-off approach). DHM automatically calculated maximum LA volume. LA volume was also calculated from CMRI images using the biplane method. LA volume measurements by DHM were correlated with CMRI. Results: DHM was able to calculate LA volume in an average time of 32±8 seconds, without additional human input. Furthermore, inter-technique correlations showed that LA volume measurements made via DHM correlated very well with LA volume measurements made via CMRI (R=0.85, p&lt;0.005). (Figure 1) Conclusions: In children, fully automated evaluation of LA volume based on artificial intelligence is a viable alternative to time-consuming 3D analysis when compared to a CMRI gold standard. This method of “hands-off” analysis may prove to be useful in situations where trained 3D personnel are unavailable. Furthermore, the utilization of this method may result in a greater integration of 3D LA volume into routine clinical practice.
Abstract 17004: Using mHealth to Capture Patient-Reported Sexual Satisfaction in Heart Failure
Authors: Brittany N Taylor, Meghan Reading Turchioe, Parag Goyal, Ruth M Masterson Creber
Journal: Circulation (2020)

Introduction: Over 60% of heart failure (HF) patients have reported problems with sexual satisfaction, which is a major reason for medication non-adherence. While many patients are reticent to verbally self-report impaired sexual satisfaction, mobile health (mHealth) technology may improve patient comfort in reporting these symptoms. We aimed to evaluate the feasibility of HF patients using mHealth to self-report sexual satisfaction by comparing responders to non-responders and evaluating symptom burden. Methods: We prospectively recruited HF patients from inpatient and outpatient cardiology clinics at an urban academic medical center from October 2016 to January 2017. Patients completed Patient Reported Outcomes Measurement Information System (PROMIS ® ) questionnaires via an mHealth application, mi.Symptoms . The specific outcomes of interest were fatigue- and pain-related impairment of sexual satisfaction, due to the prevalence of those symptoms in HF. Data were analyzed using descriptive statistics and Chi-square tests to evaluate differences between responders and non-responders. Results: The mean age of participants (n=168) was 59 years (±12.5); 37% were female; 37% were Latino; 32% were Black, 32% White, and 36% Other Race . Few significant differences in demographic characteristics of responders and non-responders were noted ( Table ). Of the 117 participants (69.6%) who responded regarding fatigue, 59 (50.4%) indicated that fatigue affected sexual satisfaction “quite a bit” or “very much.” Of the 114 participants (67.9%) who responded regarding pain, 44 (38.6%) indicated that pain affected sexual satisfaction “quite a bit” or “very much.” Conclusion: This study showed that mHealth can be a feasible way to collect sexual satisfaction data with fairly high response rates and few differences between responders and non-responders. Participants’ reported high burden of impairment underscores the importance of measuring this symptom.
Recent Advances in Printing Technologies of Nanomaterials for Implantable Wireless Systems in Health Monitoring and Diagnosis
Authors: Robert Herbert, Hyo‐Ryoung Lim, Sehyun Park, Jong‐Hoon Kim, Woon‐Hong Yeo
Journal: Advanced Healthcare Materials (2021)

Abstract The development of wireless implantable sensors and integrated systems, enabled by advances in flexible and stretchable electronics technologies, is emerging to advance human health monitoring, diagnosis, and treatment. Progress in material and fabrication strategies allows for implantable electronics for unobtrusive monitoring via seamlessly interfacing with tissues and wirelessly communicating. Combining new nanomaterials and customizable printing processes offers unique possibilities for high‐performance implantable electronics. Here, this report summarizes the recent progress and advances in nanomaterials and printing technologies to develop wireless implantable sensors and electronics. Advances in materials and printing processes are reviewed with a focus on challenges in implantable applications. Demonstrations of wireless implantable electronics and advantages based on these technologies are discussed. Lastly, existing challenges and future directions of nanomaterials and printing are described.
Abstract 045: Declines In Acute Myocardial Infarction And Stroke Emergency Department Visits Observed During Covid-19 Restrictions In North Carolina
Authors: Eugenia Wong, Wayne D Rosamond, Mehul D Patel, Anna Waller
Journal: Circulation (2021)

Introduction: Efforts to control the COVID-19 pandemic brought sweeping social change, with stay-at-home orders and physical distancing mandates in 43 of 50 states by April 2020. Early on, isolated studies around the world described reduced hospital admissions. Reports from some US hospitals also described declines in catheterization laboratory activations, and acute myocardial infarction (AMI) and stroke admissions. However, there have been few population-based analyses of emergency department (ED) visits to verify these initial reports and describe longer term impacts of the pandemic on care seeking behavior. Hypothesis: We hypothesized that AMI and stroke ED visits in North Carolina (NC) would decrease substantially after a statewide stay-at-home order was announced on March 27, 2020. Methods: We analyzed all ED visits from January 5 to August 28, 2020 using data collected by the NC Disease Event Tracking and Epidemiologic Collection Tool, a syndromic surveillance system that automatically gathers ED data in near-real time for all EDs in NC. Counts of AMI and stroke/transient ischemic attack (TIA) were ascertained using ICD-10-CM diagnosis codes. We compared weekly 2020 ED visit data before and after NC’s stay-at-home order, and to 2019 ED visit data. Results: Overall ED volume declined by 44% in the weeks before and after the stay-at-home order ( Figure ) while the prior year’s ED volume stayed steady at ~100,000 visits per week. From January 5 to March 28, there were 593 AMI and 791 stroke/TIA visits per week on average. By April 11, ED visits reached a nadir at 426 AMI and 543 stroke/TIA visits per week, representing a 28% and 31% decrease, respectively. Since June, AMI and stroke/TIA ED visits have rebounded slightly but have yet to reach pre-pandemic levels. Conclusions: We observed swift declines in AMI and stroke/TIA ED visits following NC’s stay-at-home order. These findings potentially reflect the avoidance of medical care due to fears of COVID-19 exposure and may eventually result in higher associated case fatality.
Postoperative acute kidney injury in adult non-cardiac surgery: joint consensus report of the Acute Disease Quality Initiative and PeriOperative Quality Initiative
Authors: John R. Prowle, Lui G. Forni, Max Bell, Michelle S. Chew, Mark Edwards, Morgan E. Grams, Michael P. W. Grocott, Kathleen D. Liu, David McIlroy, Patrick T. Murray, Marlies Ostermann, Alexander Zarbock, Sean M. Bagshaw, Raquel Bartz, Samira Bell, Azra Bihorac, Tong J. Gan, Charles E. Hobson, Michael Joannidis, Jay L. Koyner, Denny Z. H. Levett, Ravindra L. Mehta, Timothy E. Miller, Michael G. Mythen, Mitra K. Nadim, Rupert M. Pearse, Thomas Rimmele, Claudio Ronco, Andrew D. Shaw, John A. Kellum
Journal: Nature Reviews Nephrology (2021)

Postoperative acute kidney injury (PO-AKI) is a common complication of major surgery that is strongly associated with short-term surgical complications and long-term adverse outcomes, including increased risk of chronic kidney disease, cardiovascular events and death. Risk factors for PO-AKI include older age and comorbid diseases such as chronic kidney disease and diabetes mellitus. PO-AKI is best defined as AKI occurring within 7 days of an operative intervention using the Kidney Disease Improving Global Outcomes (KDIGO) definition of AKI; however, additional prognostic information may be gained from detailed clinical assessment and other diagnostic investigations in the form of a focused kidney health assessment (KHA). Prevention of PO-AKI is largely based on identification of high baseline risk, monitoring and reduction of nephrotoxic insults, whereas treatment involves the application of a bundle of interventions to avoid secondary kidney injury and mitigate the severity of AKI. As PO-AKI is strongly associated with long-term adverse outcomes, some form of follow-up KHA is essential; however, the form and location of this will be dictated by the nature and severity of the AKI. In this Consensus Statement, we provide graded recommendations for AKI after non-cardiac surgery and highlight priorities for future research.
Single-cell multiomics dissection of basal and antigen-specific activation states of CD19-targeted CAR T cells
Authors: Zhiliang Bai, Stefan Lundh, Dongjoo Kim, Steven Woodhouse, David M Barrett, Regina M Myers, Stephan A Grupp, Marcela V Maus, Carl H June, Pablo G Camara, J Joseph Melenhorst, Rong Fan
Journal: Journal for ImmunoTherapy of Cancer (2021)

Background Autologous T cells engineered to express a chimeric antigen receptor (CAR) specific for CD19 molecule have transformed the therapeutic landscape in patients with highly refractory leukemia and lymphoma, and the use of donor-generated allogeneic CAR T is paving the way for further breakthroughs in the treatment of cancer. However, it remains unknown how the intrinsic heterogeneities of these engineered cells mediate therapeutic efficacy and whether allogeneic products match the effectiveness of autologous therapies. Methods Using single-cell mRNA sequencing in conjunction with CITE-seq, we performed multiomics characterization of CAR T cells generated from healthy donor and patients with acute lymphoblastic leukemia. CAR T cells used in this study were manufactured at the University of Pennsylvania through lentiviral transduction with a CD19-4-1BB-CD3ζ construct. Besides the baseline condition, we engineered NIH-3T3 cells with human CD19 or mesothelin expression to conduct ex vivo antigen-specific or non-antigen stimulation of CAR T cells through 6-hour coculture at a 1:1 ratio. Results We delineated the global cellular and molecular CAR T landscape and identified that transcriptional CAR tonic signaling was regulated by a mixture of early activation, exhaustion signatures, and cytotoxic activities. On CD19 stimulation, we illuminated the disparities of CAR T cells derived from different origins and found that donor CAR T had more pronounced activation level in correlation with the upregulation of major histocompatibility complex class II genes compared with patient CAR T cells. This finding was independently validated in additional datasets from literature. Furthermore, GM-CSF( CSF2 ) expression was found to be associated with functional gene productions, but it induced little impact on the CAR T activation. Conclusions Through integrated multiomics profiling and unbiased canonical pathway analyses, our results unveil heterogeneities in the transcriptional, phenotypic, functional, and metabolic profiles of donor and patient CAR T cells, providing mechanistic basis for ameliorating clinical outcomes and developing next-generation ‘off- the-shelf’ allogeneic products.
Identification of differentially expressed genes using ACP-based Gene Fishing in human squamous cell cervical carcinoma
Authors: Seung Won Huh, Su Mi Bae, Jeong Namkoong, Jeong Hoon Bae, Soo Young Hur, Gye Hyun Nam, Woong Shick Ahn
Journal: Cancer Research (2007)

3717  Aims: The aim of this study was to compare the different gene expression between the Korean women with squamous cell cervical carcinoma (SCC) and normal cervix tissue, and to identify genes that specifically or predominantly expressed by employing annealing control primer (ACP)-based GeneFishing PCR.  Materials and methods: Cervical cancer specimens were obtained from patients enrolled at the department of obstetrics and gynecology, KangNam St. Mary’s hospital, the Catholic university of Korea. Of the 18 patients with cervical cancer, 6 patients were classified as having Stage IA, 6 patients were classified as having Stage IIA, and 6 patients were classified as having Stage IIB. We used a common reference that was mixed with an equal amount of RNA extracted from non-cervical cancer patients. The profiles of expression genes between SCC and normal cervix were identified using GeneFishingTM DEG Kits, screened by BLAST search, and confirmed by semi-quantitative RT-PCR.  Results: Almost 100 differentially expressed genes (DEG) were identified in control and cervical squamous cell carcinoma. After image analysis and BLAST database search, 50 transcripts represented by at least above 2-fold change were identified. In contrast, the rest of clones and transcripts within 2-fold change were not used. Of the identified 50 DEGs, 30 up-regulated expressions and 20 down-regulated expressions were sequenced. Among 50 clones selected by performing ACP-based GeneFishing PCR, six genes of different expression patterns were determined and confirmed by semi-quantitative RT-PCR. Functional roles of 2 up-regulated genes, fibrillarin and calgranulin A, and 1 down-regulated gene, clusterin, were previously known, however, functional roles of 2 up-regulated and 1 down-regulated were previously unknown.  Conclusion: We identified distinctive gene expression profiles in cervical SCC using ACP-based GeneFishing PCR in Korean women.
Consistency Between State Medical License Applications and Recommendations Regarding Physician Mental Health
Authors: Daniel Saddawi-Konefka, Ariel Brown, Isabella Eisenhart, Katharine Hicks, Eileen Barrett, Jessica A. Gold
Journal: JAMA (2021)

Physicians have higher rates of depression, burnout, and suicide than the general population. 1 Despite this, physicians infrequently seek mental health care, consistently citing fear of negative ramifications for licensing. 2,3State medical license applications often ask broad questions about mental health history or its hypothetical effect on competency, even though asking violates the Americans With Disabilities Act.In states with license applications that ask such questions, physicians are more reluctant to seek help. 4n 2018, the Federation of State Medical Boards (FSMB), an umbrella organization that advises state medical boards, published recommendations on physician wellness and burnout, 5 some of which directly relate to licensing applications.We reviewed the consistency of medical license applications with those FSMB recommendations.Methods | In July 2020, publicly available initial medical license applications from 50 states in the US; Washington, DC; Guam; the Northern Mariana Islands; and the US Virgin Islands (referred to as states hereafter) were obtained.Of 10 FSMB recommendations to state medical boards, 5 4 were evaluable in license applications (eTable in the Supplement).These recommendations included "only if impaired" (if mental health questions are asked, they are limited to conditions resulting in impairment), "only current" (if mental health questions are asked, they are limited to questions about conditions within the last 2 years), "safe haven nonreporting" (if mental health questions are asked, safe haven nonreporting is offered [ie, allowing physicians to not report diagnoses or treatment history if they are being monitored by and are in good standing with a Physician Health Program]), and "supportive language" (inclusion of supportive or normalizing language regarding seeking mental health care).If no questions were asked that could require disclosure of a mental health condition, the application was coded as consistent with the first 3 of these recommendations.Data from each application were coded for consistency with each of these 4 recommendations by 2 authors (I.E.and K.H.), with discrepancies resolved by a third author (D.S.-K.).Each state received an overall score for consistency ranging from 0 (consistent with none of the evaluable recommendations) to 4 (consistent with all evaluable recommendations).Data related exclusively to substance use were excluded from our analysis.
The Relationship between the Volume of Epicardial Adipose Tissue and Infarct Size in Patients with a First STEMI: Cardiac MRI Study
Authors: Gohbara Masaomi, Iwahashi Noriaki, Kataoka Shunsuke, Konishi Masaaki, Maejima Nobuhiko, Tsukahara Kengo, Tahara Yoshio, Hibi Kiyoshi, Kosuge Masami, Ebina Toshiaki, Umemura Satoshi, Kimura Kazuo
Journal: Circulation (2014)
REPLY:
Authors: Binu V. John, Yangyang Deng, Paul Martin, Cynthia Levy, Tamar H. Taddei, David E. Kaplan, Bassam Dahman
Journal: Hepatology (2021)

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Vascular mechanisms and manifestations of COVID-19
Authors: Marcel Levi, Michiel Coppens
Journal: The Lancet Respiratory Medicine (2021)

process is dominant in a given patient at a given time.Corticosteroids can have a deleterious effect in the context of immunosuppression by promoting viral replication and prolonging viral infections. 12In contrast, a recent study suggested that corticosteroids might be beneficial only in patients with severe COVID-19 and a hyperinflammatory response. 13Likewise, a glaring absence in many conceptual immunobiological frameworks is the consistent and robust association of COVID-19 severity with older age.Although the reasons for this association remain incompletely understood, the immense protection from severe COVID-19 afforded by youth might imply that immunosenescence plays a crucial part in the host response, which is responsible for viral clearance in severe COVID-19. 14Analysis of data that are able to distill these many competing factors at an individual level might be needed to fully realise the potential of immunotherapies in COVID-19.Taken together, the first three papers in this Series 2,3,5 suggest that a precision-based approach to treatment might be needed, which is one of the central challenges facing the field.Phenotypes based on a systemic inflammatory response or an immunosuppressive state, or on biological markers of coagulopathy and endothelial dysfunction, might help to identify treatment-responsive subgroups of patients.COVID-19 phenotypes based on the temporal kinetics of immunological markers or disease trajectories are also of interest, and might be key to unlocking the optimum timing and type of immunomodulatory therapy.The role of different SARS-CoV-2 variants and the resulting host response also warrant further evaluation.Finally, studying host immune responses in the lungs will be important, although this comes with its own technical challenges.Future clinical practice is likely to involve targeted therapies based on biological, genetic, or functional immunophenotyping.Until such a time, researchers and clinicians must continue to carry out careful and well planned RCTs, acknowledge the complexity of the challenge we face, and assiduously collect biological specimens to better understand host immune responses to pathogens and their implications for the treatment of patients.