tbuckley/cabot-search huggingface dataset:
Systematic Review of Counseling and Behavioral Interventions for Healthy Weight and Weight Gain in Pregnancy From the US Preventive Services Task Force—Reply
Authors: Amy G. Cantor, Rebecca M. Jungbauer, Roger Chou
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract #5206: Molecular features and therapeutic targets in stage 1 epithelial ovarian cancer
Authors: Takayo Ota, Debra Bell, Jesus Gonzalez-Bosquet, Vijayalakshmi Shridhar, Lynn Hartmann, Jian-Bing Fan, Jeremy Chien
Journal: Cancer Research (2009)

Epithelial ovarian cancer represents the most aggressive gynecologic cancer, being the foremost cause of death from gynecologic malignancies in the developed countries. Two reasons mainly explain this aggressive behavior: most patients present with advanced cancer at time of diagnosis, and die of recurrences that become untreatable by conventional chemotherapies. Recent studies proposed that epithelial ovarian cancer (EOC) can be classified into two types based on the two main pathways of tumorigenesis: low-grade neoplasms that arise in a stepwise manner from borderline tumors are considered type I, whereas high-grade neoplasms without definable precursor lesions are considered type II (Shih Ie, 2004). In these two types of tumors, loss of p53 function is suggested to be an early molecular event associated with de novo carcinogenesis of type II EOC, whereas type I EOC arising from the progression of borderline tumors frequently contain wild type p53. However, detailed gene expression analysis of type I and type II EOC is still needed to identify additional characteristic differences between type I and type II cancer. Using whole-genome DASL technology from Illumina, Inc., we analyzed gene expression from formalin-fixed paraffin-embedded (FFPE) biospecimens collected from 5 patients with stage I EOC and 5 patients with borderline tumors. As preliminary results, we found that WG-DASL analysis of gene expression, consisting of 24,000 annotated probes correctly classified serous borderline tumors from stage I serous carcinoma of the ovary. Two different blocks of the same patient, also clustered together, demonstrating the robustness of the assays. Gene set class comparison analysis of differentially expressed genes between cancer and borderline tumors identified critical known pathways, such as p53 and E2F pathways to be altered in cancer. These results demonstrate the validity of gene expression analysis to define altered pathways. We applied a gene set of 477 genes, obtained from class prediction analysis, to three independent data sets available at Gene Expression Omnibus website. Class prediction analysis indicates that our gene set can correctly classify borderline tumors from cancer with over 80% accuracy, sensitivity and specificity for each class. These results therefore demonstrate the feasibility of performing gene expression analysis and classification of tumors based on gene expression obtained from FFPE samples.  Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 5206.
The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis
Authors: Christiaan J. Stavast, Iris van Zuijen, Elena Karkoulia, Arman Özçelik, Antoinette van Hoven-Beijen, Leticia G. Leon, Jane S. A. Voerman, George M. C. Janssen, Peter A. van Veelen, Monika Burocziova, Rutger W. W. Brouwer, Wilfred F. J. van IJcken, Alex Maas, Eric M. Bindels, Vincent H. J. van der Velden, Christopher Schliehe, Peter D. Katsikis, Meritxell Alberich-Jorda, Stefan J. Erkeland
Journal: Leukemia (2021)

Abstract MIR139 is a tumor suppressor and is commonly silenced in acute myeloid leukemia (AML). However, the tumor-suppressing activities of miR-139 and molecular mechanisms of MIR139 -silencing remain largely unknown. Here, we studied the poorly prognostic MLL-AF9 fusion protein-expressing AML. We show that MLL-AF9 expression in hematopoietic precursors caused epigenetic silencing of MIR139 , whereas overexpression of MIR139 inhibited in vitro and in vivo AML outgrowth. We identified novel miR-139 targets that mediate the tumor-suppressing activities of miR-139 in MLL-AF9 AML. We revealed that two enhancer regions control MIR139 expression and found that the polycomb repressive complex 2 (PRC2) downstream of MLL-AF9 epigenetically silenced MIR139 in AML. Finally, a genome-wide CRISPR-Cas9 knockout screen revealed RNA Polymerase 2 Subunit M (POLR2M) as a novel MIR139 -regulatory factor. Our findings elucidate the molecular control of tumor suppressor MIR139 and reveal a role for POLR2M in the MIR139 -silencing mechanism, downstream of MLL-AF9 and PRC2 in AML. In addition, we confirmed these findings in human AML cell lines with different oncogenic aberrations, suggesting that this is a more common oncogenic mechanism in AML. Our results may pave the way for new targeted therapy in AML.
The H2A.Z-nucleosome code in mammals: emerging functions
Authors: Yolanda Colino-Sanguino, Susan J. Clark, Fatima Valdes-Mora
Journal: Trends in Genetics (2021)

H2A.Z is a histone variant that provides specific structural and docking-side properties to the nucleosome, resulting in diverse and specialised molecular and cellular functions. In this review, we discuss the latest studies uncovering new functional aspects of mammalian H2A.Z in gene transcription, including pausing and elongation of RNA polymerase II (RNAPII) and enhancer activity; DNA repair; DNA replication; and 3D chromatin structure. We also review the recently described role of H2A.Z in embryonic development, cell differentiation, neurodevelopment, and brain function. In conclusion, our cumulative knowledge of H2A.Z over the past 40 years, in combination with the implementation of novel molecular technologies, is unravelling an unexpected and complex role of histone variants in gene regulation and disease.
Depressive Symptom Assessment in Medically Ill Patients
Authors: Mu-Hong Chen, Ping-Tao Tseng, Chih-Sung Liang
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heightened turnover and failed maturation of monocyte-derived macrophages in murine chronic granulomatous disease
Authors: Sophie L. Gibbings, Kelsey C. Haist, Heidi Nick, S. Courtney Frasch, Teagan H. Glass, Brian Vestal, Thomas Danhorn, Kara J. Mould, Peter M. Henson, Donna L. Bratton
Journal: Blood (2021)
TCT-94 Clinical Outcomes of Left Atrial Appendage Occlusion Versus Direct Oral Anticoagulation in Atrial Fibrillation Patients With Previous Ischemic Stroke
Authors: Kasper Korsholm, Jan Valentin, Dorte Damgaard, Hans-Christoph Diener, John Camm, Ulf Landmesser, David Hildick-Smith, Søren Johnsen, Jens Erik Nielsen-Kudsk
Journal: Journal of the American College of Cardiology (2021)
TCT-376 Clopidogrel Versus Aspirin for Long-Term Secondary Prevention of Atherosclerosis: A Meta-Analysis
Authors: Ahmad Al-Abdouh, Waiel Abusnina, Mohammed Mhanna, Qais Radaideh, Ahmad Jabri, Anan Abu Rmilah, Hossam Alzu'bi, Mahmoud Barbarawi
Journal: Journal of the American College of Cardiology (2021)
Strong Predictors of Chromosomal Aberrations and Myeloid Neoplasia Following Immunosuppression Therapy for Severe Aplastic Anemia: A Retrospective Cohort Study
Authors: Emma M. Groarke, Bhavisha A. Patel, Ruba Shalhoub, Fernanda Gutierrez-Rodrigues, Parth Desai, Harshraj Leuva, Casey Paton, Nina Spitofsky, Jennifer Lotter, Olga Rios, Richard W. Childs, David J. Young, Alina Dulau-Florea, Cynthia E. Dunbar, Katherine R. Calvo, Colin O. Wu, Neal S. Young
Journal: Blood (2021)
Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus
Authors: Damien J. Downes, Amy R. Cross, Peng Hua, Nigel Roberts, Ron Schwessinger, Antony J. Cutler, Altar M. Munis, Jill Brown, Olga Mielczarek, Carlos E. de Andrea, Ignacio Melero, Deborah R. Gill, Stephen C. Hyde, Julian C. Knight, John A. Todd, Stephen N. Sansom, Fadi Issa, James O. J. Davies, Jim R. Hughes
Journal: Nature Genetics (2021)
Comparison of Rates of AKI Between Two COVID-19 Surges in Hospitalized Patients in the Bronx
Authors: Bruna Taveras Garcia, Maria V. Avendano, Tianying Li, John D. Wagner, Natalia Cavin, Rosalba Y. Santana De Roberts, Kisra Anis, Naheed Ansari, Belinda Jim, Nidhi Varma, Sneha Chelimeda, Anjali Acharya
Journal: Journal of the American Society of Nephrology (2021)

Background: The incidence of AKI in COVID 19 is very variable across the world. In New York City it was as high as 36% in a large series in early 2020. However, the incidence of AKI during the second surge between Oct of 2020 to early 2021 is unknown. In this study, we compared these two COVID-19 periods for the incidence of AKI amongst hospitalized patients. Methods: This was a multi-center, retrospective cohort study of patients hospitalized with COVID-19 between March 1st and July 16th 2020 (n=1,719), and between October 15th 2020 and February 28th 2021(n=997) in two NYC public hospitals, (total n= 2,716). Patients   50 (Ref range: <50) presented in the first surge than the second surge (p<0.0001). No differences in the peak potassium and peak D-Dimer, or ICU admission rates were seen between two surges. However, significantly more AKI patients in the first surge were on mechanical ventilation as compared to the second surge (p=0.0196). Conclusions: To our knowledge this is the first comparison reported between rates of AKI in hospitalized patients with COVID-19 during two different surge periods. The difference may be related to less severe disease during the second surge, though ICU admission rate was the same. Better care established by the time of the second surge and improved therapeutics such as early use of anti-viral agents, corticosteroids, and anticoagulation may have contributed to better outcomes. Improvement in care of COVID-19 in the second surge may have contributed to a decline in the incidence of AKI. Future studies are needed to see if this trend towards lower AKI incidence continues.
26823 A giant facial plexiform neurofibromatosis is driven by RAF1 gain mutation
Authors: Minh Van Hoang, Phung Kim Thi Ngo, Anh Quynh Ngoc Phan, Bao Chi Bui, Dung Tu Phan Nguyen, Vien The Tran, Giang Huong Tran
Journal: Journal of the American Academy of Dermatology (2021)
The double-edged sword: Harnessing PD-1 blockade in tumor and autoimmunity
Authors: Juhi R. Kuchroo, David A. Hafler, Arlene H. Sharpe, Liliana E. Lucca
Journal: Science Immunology (2021)

Immune checkpoint blockade has demonstrated success in treating cancer but can lead to immune-related adverse events (irAEs), illustrating the centrality of these pathways in tolerance. Here, we describe programmed cell death protein 1 (PD-1) control of T cell responses, focusing on its unique restraint of regulatory T cell function. We examine successes and limitations of checkpoint blockade immunotherapy and review clinical and mechanistic features of irAEs. Last, we discuss strategies to modulate PD-1 blockade to enhance antitumor immunity while limiting autoimmunity.
The context-specific role of germline pathogenicity in tumorigenesis
Authors: Preethi Srinivasan, Chaitanya Bandlamudi, Philip Jonsson, Yelena Kemel, Shweta S. Chavan, Allison L. Richards, Alexander V. Penson, Craig M. Bielski, Christopher Fong, Aijazuddin Syed, Gowtham Jayakumaran, Meera Prasad, Jason Hwee, Selcuk Onur Sumer, Ino de Bruijn, Xiang Li, JianJiong Gao, Nikolaus Schultz, Roy Cambria, Jesse Galle, Semanti Mukherjee, Joseph Vijai, Karen A. Cadoo, Maria I. Carlo, Michael F. Walsh, Diana Mandelker, Ozge Ceyhan-Birsoy, Jinru Shia, Ahmet Zehir, Marc Ladanyi, David M. Hyman, Liying Zhang, Kenneth Offit, Mark E. Robson, David B. Solit, Zsofia K. Stadler, Michael F. Berger, Barry S. Taylor
Journal: Nature Genetics (2021)
TCT-235 Annular Size and Its Interaction With Self-Expandable Versus Balloon-Expandable Transcatheter Heart Valves for the Treatment of Patients With Severe Bicuspid Aortic Valve Stenosis: Insights from the BEAT Registry
Authors: Alfonso Ielasi, Elisabetta Moscarella, Antonio Mangieri, Francesco Giannini, Didier Tchetche, Won-Keun Kim, Jan-Malte Sinning, Uri Landes, Ran Kornowski, Ole de Backer, Georg Nickenig, Chiara de Biase, Lars Sondergaard, Federico de Marco, Francesco Bedogni, Marco Ancona, Matteo Montorfano, Damiano Regazzoli, Giulio Stefanini, Stefan Toggweiler, Corrado Tamburino, Sebastiano Immè, Giuseppe Tarantini, Horst Sievert, Ulrich Schaefer, Jörg Kempfert, Azeem Latib, Paolo Calabrò, Massimo Medda, Maurizio Tespili, Antonio Colombo
Journal: Journal of the American College of Cardiology (2021)
Double-lung transplantation followed by delayed percutaneous repair for atrial septal defect-associated pulmonary arterial hypertension
Authors: Pierre Gazengel, Sébastien Hascoët, Myriam Amsallem, Laurent Savale, David Montani, Olaf Mercier, Marc Humbert, Elie Fadel, Jérôme Le Pavec
Journal: European Respiratory Journal (2021)

<b>In pulmonary hypertension with right heart failure due to atrial septal defect, double-lung transplantation then percutaneous defect closure 3–6 months later compared favourably with the standard approach consisting of heart–lung transplantation</b>https://bit.ly/3BjdLzw
TCT-15 Management and Outcomes of Patients With Left Atrial Appendage Thrombus Before Percutaneous Closure: LAPTOP Registry
Authors: Gabriela Tirado-Conte, Luis Alfonso Marroquin-Donday, Witold Streb, Hipolito Gutierrez, Giacomo Boccuzzi, Dabit Arzamendi, Ignacio Cruz-Gonzalez, Jung-Sun Kim, Xavier Freixa, Jose Ramon Lopez-Minguez, Ole De Backer, Angela McInerney, Rodrigo Estevez-Loureiro, Afonso Freitas-Ferraz, Francesco Saia, Zenon Huczek, Livia L. Gheorghe, Pablo Salinas, Marcin Demkow, Jose Raul Delgado Arana, Zbigniew Kalarus, Ana Laffond, Yangsoo Jang, Jose Fernandez Camacho, Oh-Hyun Lee, Jose Maria Hernandez, Caterina Mas-Lladó, Berenice Caneiro-Queija, Ignacio Amat-Santos, Maciej Dabrowski, Luis Nombela-Franco
Journal: Journal of the American College of Cardiology (2021)
TCT-414 Safety and Efficacy of Dedicated Guidewire, Microcatheter, and Guide Catheter Extension Technologies for Chronic Total Coronary Occlusion Revascularization: Primary Results of the Teleflex Chronic Total Occlusion Study
Authors: David Kandzari, Khaldoon Alaswad, Farouc Amin Jaffer, Emmanouil Brilakis, Kevin Croce, Kathleen Kearney, Anthony Spaedy, Robert Yeh, Craig Thompson, William Nicholson, R. Michael Wyman, Robert Riley, Alexandra Lansky, Dimitri Karmpaliotis
Journal: Journal of the American College of Cardiology (2021)
The enhanced photocatalytic sterilization of MOF-Based nanohybrid for rapid and portable therapy of bacteria-infected open wounds
Authors: Chaofeng Wang, Yue Luo, Xiangmei Liu, Zhenduo Cui, Yufeng Zheng, Yanqin Liang, Zhaoyang Li, Shengli Zhu, Jie Lei, Xiaobo Feng, Shuilin Wu
Journal: Bioactive Materials (2021)

Open wounds are prone to infection and difficult to heal, which even threatens the life of patients because bacterial infections can induce other lethal complications without prompt treatment. The commonly used antibiotics treatment for bacterial infections has been reported to cause globally bacterial resistance and even the occurrence of superbacteria. The highly effective and antibiotic-independent therapeutic strategies are urgently needed for treating various kinds of bacteria-infected diseases. In this work, we synthesized an eco-friendly nanohybrid material (ZnDMZ) consisting of a kind of biodegradable metal organic framework (MOF, ZIF-8) combined with Zn-doped MoS2 (Zn-MoS2) nanosheets, which exhibited great ability to kill bacteria and promote the healing of bacteria-infected wounds under 660 nm light irradiation. The underlying mechanism is that besides the local hyperthermia, the nanohybrid material exhibits enhanced photocatalytic performance than single component in it, i.e., it can also be excited by 660 nm light to produce more oxygen radical species (ROS) due to the following factors. On one hand, the Zn doping can reduce the work function and the band gap of MoS2, which promotes the movement of photoexcited electrons to the surface of the material. On the other hand, the combination between Zn-MoS2 and MOF induces the formation of a built-in electric field due to their work function difference, thus accelerating the separation of photoexcited electron-hole pairs. Because of the synergy of photocatalytic effect, photothermal effect and the released Zn ions, the synthesized ZnDMZ possessed a highly effective antibacterial efficacy of 99.9% against Staphylococcus aureus under 660 nm light irradiation for 20 min without cytotoxicity. In vivo tests showed that this nanohybrid material promoted the wound healing due to the released Zn ions. This nanohybrid will be promising for rapid and portable treatment of bacteria-infected open wounds in pathogenic bacteria contaminated environments.
Partha Kar: Making sense of the health multiverse
Authors: Partha Kar
Journal: BMJ (2021)

The world of Marvel movies and comics involves a whole multiverse where it can be hard to make sense of what’s really happening—which Spider-Man exists in which reality, or which main characters are actually dead or alive. As it’s a fantasy world, we can enjoy the moviemakers’ artistic licence in the spirit intended.

A problem arises when that sort of fantastical approach starts to take hold in the NHS, when people create a parallel universe where the pandemic has been overcome, with no shred of the virus left. It’s in this world that government pronouncements on GP access have arrived. Amid some well meant intentions by the NHS to look at variation, along with “offers of help,” one initiative has caused much consternation—a government drive for more face-to-face consultations, despite an escalating infection rate and the near complete dismantling of social distancing rules and mask use.

It’s as though Daily Mail readers or the tweets of a Paul3467 with two followers on Twitter have convinced everyone that, during a pandemic, face-to-face GP consultations are exactly the area to concentrate on. Add in the …
In men with rectal chlamydia, 7-d doxycycline increased microbiologic cure at 4 wk vs. 1-dose azithromycin
Authors: Thomas Fekete
Journal: Annals of Internal Medicine (2021)

ACP Journal ClubNovember 2021In men with rectal chlamydia, 7-d doxycycline increased microbiologic cure at 4 wk vs. 1-dose azithromycinThomas Fekete, MDThomas Fekete, MDLewis Katz School of Medicine of Temple University, Philadelphia, Pennsylvania, USA (T.F.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJ202111160-129 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationLau A, Kong FYS, Fairley CK, et al. Azithromycin or doxycycline for asymptomatic rectal chlamydia trachomatis. N Engl J Med. 2021;384:2418-27. https://pubmed.ncbi.nlm.nih.gov/34161706Clinical Impact RatingsGIM/FP/GP: Infectious Disease: Reference1. Bachmann LH, Stephens J, Richey CM, et al. Measured versus self-reported compliance with doxycycline therapy for chlamydia-associated syndromes: high therapeutic success rates despite poor compliance. Sex Transm Dis. 1999;26:272-8. [PMID: 10333280] Google Scholar Author, Article, and Disclosure InformationAffiliations: Lewis Katz School of Medicine of Temple University, Philadelphia, Pennsylvania, USA (T.F.)Disclosures: The commentator has reported no disclosures of interest. The form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M20-7322.This article was published at Annals.org on 2 November 2021. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics November 2021Volume 174, Issue 11Page: JC129 ePublished: 2 November 2021 Issue Published: November 2021 Copyright & PermissionsCopyright © 2021 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Biophysical insights into modulating lipid digestion in food emulsions
Authors: Alejandra Acevedo-Fani, Harjinder Singh
Journal: Progress in Lipid Research (2021)

During the last decade, major scientific advances on understanding the mechanisms of lipid digestion and metabolism have been made, with a view to addressing health issues (such as obesity) associated with overconsumption of lipid-rich and sucrose-rich foods. As lipids in common foods exist in the form of emulsions, the structuring of emulsions has been one the main strategies for controlling the rate of lipid digestion and absorption, at least from a colloid science viewpoint. Modulating the kinetics of lipid digestion and absorption offers interesting possibilities for developing foods that can provide control of postprandial lipaemia and control the release of lipophilic compounds. Food emulsions can be designed to achieve considerable differences in the kinetics of lipid digestion but most research has been applied to relatively simple model systems and in in vitro digestion models. Further research to translate this knowledge into more complex food systems and to validate the results in human studies is required. One promising approach to delay/control lipid digestion is to alter the stomach emptying rate of lipids, which is largely affected by interactions of emulsion droplets with the food matrices. Food matrices with different responses to the gastric environment and with different interactions between oil droplets and the food matrix can be designed to influence lipid digestion. This review focuses on key scientific advances made during the last decade on understanding the physicochemical and structural modifications of emulsified lipids, mainly from a biophysical science perspective. The review specifically explores different approaches by which the structure and stability of emulsions may be altered to achieve specific lipid digestion kinetics.