tbuckley/cabot-search huggingface dataset:
Glioma-derived exosomes hijack the blood–brain barrier to facilitate nanocapsule delivery via LCN2
Authors: Chao Yang, Ye Wu, Lin Wang, Sidi Li, Junhu Zhou, Yanli Tan, Jia Song, Huike Xing, Kaikai Yi, Qi Zhan, Jin Zhao, Qixue Wang, Xubo Yuan, Chunsheng Kang
Journal: Journal of Controlled Release (2022)
Exposure Histories and Cancer Risk—What Can We Learn?
Authors: Patrick T. Bradshaw
Journal: JAMA Oncology (2022)

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FimH confers mannose-targeting ability to Bacillus Calmette-Guerin for improved immunotherapy in bladder cancer
Authors: Yang Zhang, Fan Huo, Qiang Cao, Ru Jia, Qiju Huang, Zhu A Wang, Dan Theodorescu, Qiang Lv, Pengchao Li, Chao Yan
Journal: Journal for ImmunoTherapy of Cancer (2022)

Background Bladder cancer is a common disease worldwide with most patients presenting with the non-muscle-invasive form (NMIBC) at initial diagnosis. Postoperational intravesical instillation of BCG is carried out for patients with high-risk disease to reduce tumor recurrence and progression to muscle invasive disease. However, BCG can also have side effects or be ineffective in some patients because it cannot enter the cancer cells. Thus, to improve the efficacy of BCG immunotherapy is the long-term pursuit of the bladder cancer field. Methods To increase the adhesion of BCG to the urothelium we overexpressed FimH, a mannose binding protein naturally used by uropathogenic Escherichia coli to adhere to human urothelium, onto the surface of BCG. The adhesion/internalization ability of rBCG-S.FimH was examined in mouse bladder by fluorescence microscopy. Preclinical evaluation of antitumor efficacy was carried out in orthotopic mouse models of bladder cancer and in human peripheral blood mononuclear cells. Mechanistic studies were carried out using toll-like receptor 4 (TLR4) knockout mice. Immune cells and cytokines in the serum, tumor and lymph nodes were analyzed by flow cytometry, PCR, ELISA and ELISPOT. Results rBCG-S.FimH exhibited markedly improved adhesion and more rapid internalization into urothelial cells than wild-type BCG, resulting in more potent antitumor activity in orthotopic murine models of bladder cancer. To our surprise, rBCG-S.FimH elicited a much more prominent Th1-biased immune response known to be positively correlated with BCG efficacy. Mechanistic studies using TLR4 knockout mouse showed that rBCG-S.FimH could induce enhanced dendritic cell activation and tumor antigen-specific immune response in a TLR4-dependent manner. Furthermore, human peripheral blood mononuclear cells stimulated by rBCG-S.FimH also showed better tumoricidal effects than those using wild-type BCG. Conclusion rBCG-S.FimH is a novel BCG strain with significantly improved efficacy against bladder cancer. Since intravesical BCG immunotherapy is the first-line treatment for NMIBC, which accounts for more than 70% of all bladder cancer cases, our results provide a compelling rationale for clinical development.
PROSPECTIVE COMPARISONS OF CHAMBER AND VALVE QUANTIFICATION BY ECHOCARDIOGRAPHY VERSUS CARDIAC MAGNETIC RESONANCE IMAGING IN AORTIC AND MITRAL REGURGITATION PATIENTS
Authors: Tom Kai Ming Wang, Zoran Popovic, L. Leonardo Rodriguez, Michael Bolen, Laurie Ann Moennich, Katy Rutkowski, Brian P. Griffin, Richard A. Grimm, Scott D. Flamm, Deborah Kwon
Journal: Journal of the American College of Cardiology (2022)
DECREASED RIGHT VENTRICULAR FREE WALL STRAIN PREDICTS INCREASED MORTALITY EVEN IN THE SETTING OF NORMAL FRACTIONAL AREA CHANGE, TRICUSPID ANNULAR PLANE EXCURSION, AND NORMAL RIGHT VENTRICULAR SIZE IN PATIENTS WITH GREATER THAN MODERATE TRICUSPID REGURGITATION
Authors: Vibha Murthy, Uswa Khan, Elizabeth Wright, Shizhen Liu, Pradeep K. Yadav, Vivek Rajagopal, Amy E. Simone, Vibhav S. Rangarajan, Peter Flueckiger, Vinod H. Thourani, Mani A. Vannan
Journal: Journal of the American College of Cardiology (2022)
It is not too late to achieve global covid-19 vaccine equity
Authors: Gavin Yamey, Patricia Garcia, Fatima Hassan, Wenhui Mao, Kaci Kennedy McDade, Madhukar Pai, Senjuti Saha, Philip Schellekens, Andrea Taylor, Krishna Udayakumar
Journal: BMJ (2022)

During the covid-19 pandemic, we have seen the best of international collective action and its limits.Global scientific cooperation drove the development of safe, highly effective covid-19 vaccines in under one year. 1Yet we have also witnessed global vaccine inequity, 2 in which low and middle income countries have "limited supply and limited vaccine brand options." 3 With the omicron wave dissipating, several well vaccinated high income nations with stockpiles of covid-19 vaccines are rushing to declare the pandemic over, reminding us of how things unfolded with tuberculosis, malaria, and HIV/AIDS in the past.But the pandemic is not over and 2.8 billion people remain completely unvaccinated.Now is the time to recommit to, and further invest in, equitable and effective country led vaccination campaigns.In this paper, we briefly examine how global vaccine inequity arose, lay out a renewed case for urgently ramping up our commitment to vaccine equity, and propose principles to ensure no one is left behind in the quest to vaccinate the world.Fig 1 | Booster coverage of total population, by income.Country observations (centre points) of boosters per 100 people by income group and total population size (area) with group averages (lines).HIC=high income countries; UMIC=upper middle income countries; LMIC=lower middle income countries; LIC=low income countries.
Concomitant Urinary Triple Phosphate and Cystine Crystals
Authors: Sebastien Kissling, Olivier Bonny
Journal: New England Journal of Medicine (2022)

A 37-year-old man with cystinuria and a recent urinary tract infection presented to the nephrology clinic for follow-up. Microscopic examination of a spun urine specimen showed concomitant triple phosphate and cystine crystals.
CLO22-041: A Phase 2 Study of Magrolimab Combination Therapy in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
Authors: A. Dimitrios Colevas, John J Park, Bruno Fang, Jiang Shao, Lance U'Ren, Jared Odegard, Indu Lal, Minh Phan, Kyaw Z. Thein, Douglas Adkins
Journal: Journal of the National Comprehensive Cancer Network (2022)

"CLO22-041: A Phase 2 Study of Magrolimab Combination Therapy in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma" published on 31 Mar 2022 by National Comprehensive Cancer Network.
DIFFERENCES IN HEMODYNAMIC MEASUREMENT AND INTERPRETATION BETWEEN HEART FAILURE AND INTERVENTIONAL CARDIOLOGISTS
Authors: Priyesh Ashok Patel, Sriram Rao, Rohan M. Goswami, David Snipelisky, Nicole B. Cyrille-Superville, Eric Jeng, Shashank S. Sinha, Jason P. Feliberti, Adam DeVore, Samer S. Najjar, Jonathan Grinstein
Journal: Journal of the American College of Cardiology (2022)
Is formalism the key to resolving the generalizability crisis? An experimental economics perspective
Authors: Zacharias Maniadis
Journal: Behavioral and Brain Sciences (2022)

Abstract I draw lessons from experimental economics. I argue that the lack of mathematical formalism cannot be usefully thought as the cause of the underappreciation of contextual and generalizability considerations. Instead, this lack is problematic because it hinders a clear relationship between theory and quantitative predictions. I also advocate a pragmatic policy-focused approach as a partial remedy to the generalizability problem.
Premetazoan Origin of Neuropeptide Signaling
Authors: Luis Alfonso Yañez-Guerra, Daniel Thiel, Gáspár Jékely
Journal: Molecular Biology and Evolution (2022)

Abstract Neuropeptides are a diverse class of signaling molecules in metazoans. They occur in all animals with a nervous system and also in neuron-less placozoans. However, their origin has remained unclear because no neuropeptide shows deep homology across lineages, and none have been found in sponges. Here, we identify two neuropeptide precursors, phoenixin (PNX) and nesfatin, with broad evolutionary conservation. By database searches, sequence alignments, and gene-structure comparisons, we show that both precursors are present in bilaterians, cnidarians, ctenophores, and sponges. We also found PNX and a secreted nesfatin precursor homolog in the choanoflagellate Salpingoeca rosetta. PNX, in particular, is highly conserved, including its cleavage sites, suggesting that prohormone processing occurs also in choanoflagellates. In addition, based on phyletic patterns and negative pharmacological assays, we question the originally proposed GPR-173 (SREB3) as a PNX receptor. Our findings revealed that secreted neuropeptide homologs derived from longer precursors have premetazoan origins and thus evolved before neurons.
Mannan-decorated pathogen-like polymeric nanoparticles as nanovaccine carriers for eliciting superior anticancer immunity
Authors: Yudi Xu, Sheng Ma, Jiayu Zhao, Hongyu Chen, Xinghui Si, Zichao Huang, Zhentao Yu, Wantong Song, Zhaohui Tang, Xuesi Chen
Journal: Biomaterials (2022)
A Renal Cyst Invaded by Infiltrating Renal Cell Carcinoma With Multiple Hypermetabolic Bone Metastases as the Initial Presentation
Authors: Shu Wang, Bulin Du, Xuena Li, Yaming Li
Journal: Clinical Nuclear Medicine (2022)

Abstract Cystic renal cell carcinoma (RCC) refers to an indolent version of RCC composed predominantly of cysts, and it is associated with good prognosis. We showed the FDG PET/CT findings in a patient with multiple hypermetabolic bone metastases presenting with pain in the left shoulder and upper abdomen, who was later found to have cystic RCC. FDG PET/CT demonstrated hypermetabolic bone lesions and slight thickening of the renal cyst wall with light metabolism. This report indicates the risk of misdiagnosing cystic RCC as a renalcyst.
EPR22-117: Evaluation of the Influence of the BRAF V600E Mutation and of the Microsatellite Instability on the Overall Survival (OS) of Metastatic CRC Patients Based on Real World Data
Authors: Aparna Parikh, Maria Cecilia Vieira, Benjamin Li, Neil Lamarre, Anup Abraham, Craig Parzynski, Michelle Edwards
Journal: Journal of the National Comprehensive Cancer Network (2022)

"EPR22-117: Evaluation of the Influence of the BRAF V600E Mutation and of the Microsatellite Instability on the Overall Survival (OS) of Metastatic CRC Patients Based on Real World Data" published on 31 Mar 2022 by National Comprehensive Cancer Network.
REMOTE MICROSAMPLE BLOOD COLLECTION AND PROTEOMIC ANALYSIS OF PATIENTS WITH PRIOR TAKOTSUBO CARDIOMYOPATHY SHOWS PROFILE DISTINCT FROM NORMAL CONTROLS
Authors: Kirstin Washington, Paul Marano, Blandine Chazarin, Jenna Maughan, Okezi Obrutu, Benita Tjoe, Romana Herscovici, Prizzi Moy, Chrisandra Shufelt, Thomas Rutledge, Janet Wei, Jennifer Van Eyk, C. Noel Bairey Merz
Journal: Journal of the American College of Cardiology (2022)
THE BURDEN OF UNCONTROLLED CARDIOVASCULAR RISK FACTORS IN MEN WITH PROSTATE CANCER: A RADICAL PC ANALYSIS
Authors: Harry Klimis, Jehonathan Pinthus, Bobby Shayegan, Laurence Klotz, Robert Siemens, Patrick Luke, Tamim Niazi, Vincet Fradet, Emmanuelle Duceppe, Luke Lavallee, Negareh Mousavi, Robert Hamilton, Ian Brown, Joseph Chin, Darin Gopaul, Philippe Violette, Margot Davis, Nawar Hanna, Robert Sabbagh, Osnat Itzhaki Ben Zadok, Joseph Brindaban Selvanayagam, Ludhmila Hajjar, Ariel Kann, Darryl Leong
Journal: Journal of the American College of Cardiology (2022)
Neuroimmune communication regulating pruritus in atopic dermatitis
Authors: Martin Steinhoff, Fareed Ahmad, Atul Pandey, Angeliki Datsi, Ayda AlHammadi, Sara Al-Khawaga, Aysha Al-Malki, Jianghui Meng, Majid Alam, Joerg Buddenkotte
Journal: Journal of Allergy and Clinical Immunology (2022)

Atopic dermatitis (AD) is a common, chronic-relapsing inflammatory skin disease with significant disease burden. Genetic and environmental trigger factors contribute to AD, activating 2 of our largest organs, the nervous system and the immune system. Dysregulation of neuroimmune circuits plays a key role in the pathophysiology of AD, causing inflammation, pruritus, pain, and barrier dysfunction. Sensory nerves can be activated by environmental or endogenous trigger factors, transmitting itch stimuli to the brain. On stimulation, sensory nerve endings also release neuromediators into the skin, contributing again to inflammation, barrier dysfunction, and itch. In addition, dysfunctional peripheral and central neuronal structures contribute to neuroinflammation, sensitization, nerve elongation, and neuropathic itch, thus chronification and therapy resistance. Consequently, neuroimmune circuits in skin and central nervous system may be targets to treat pruritus in AD. Cytokines, chemokines, proteases, lipids, opioids, and ions excite/sensitize sensory nerve endings, which not only induces itch but further aggravates/perpetuates inflammation, skin barrier disruption, and pruritus as well. Thus, targeted therapies for neuroimmune circuits as well as pathway inhibitors (eg, kinase inhibitors) may be beneficial to control pruritus in AD either in systemic and/or in topical form. Understanding neuroimmune circuits and neuronal signaling will optimize our approach to control all pathological mechanisms in AD, inflammation, barrier dysfunction, and pruritus.
The determinants of planetary health: an Indigenous consensus perspective
Authors: Nicole Redvers, Yuria Celidwen, Clinton Schultz, Ojistoh Horn, Cicilia Githaiga, Melissa Vera, Marlikka Perdrisat, Lynn Mad Plume, Daniel Kobei, Myrna Cunningham Kain, Anne Poelina, Juan Nelson Rojas, Be'sha Blondin
Journal: The Lancet Planetary Health (2022)

Indigenous Peoples have resiliently weathered continued assaults on their sovereignty and rights throughout colonialism and its continuing effects. Indigenous Peoples' sovereignty has been strained by the increasing effects of global environmental change within their territories, including climate change and pollution, and by threats and impositions against their land and water rights. This continuing strain against sovereignty has prompted a call to action to conceptualise the determinants of planetary health from a perspective that embodied Indigenous-specific methods of knowledge gathering from around the globe. A group of Indigenous scholars, practitioners, land and water defenders, respected Elders, and knowledge-holders came together to define the determinants of planetary health from an Indigenous perspective. Three overarching levels of interconnected determinants, in addition to ten individual-level determinants, were identified as being integral to the health and sustainability of the planet, Mother Earth.
PREDICTIVE VALUE OF INDIVIDUAL CORONARY CT-DERIVED CAD CHARACTERISTICS VARIES ACROSS ASCVD RISK STRATA: RESULTS FROM THE PROMISE TRIAL
Authors: Borek Foldyna, Michael T. Lu, Maros Ferencik, Julia Karady, Thomas Mayrhofer, Svati Shah, Neha J. Pagidipati, Pamela S. Douglas, Udo Hoffmann
Journal: Journal of the American College of Cardiology (2022)
A RARE CASE OF THROMBUS LODGED IN PATENT FORAMEN OVALE MIMICKING LEFT ATRIAL MYXOMA - A CLINICAL CONUNDRUM, DECIPHERED BY MULTIMODALITY IMAGING.
Authors: Sai Vikram Alampoondi Venkataramanan, Michael Cundiff, Sherif B. Labib
Journal: Journal of the American College of Cardiology (2022)
SACUBITRIL/VALSARTAN PROTEOMIC BIOMARKERS FOR HEART FAILURE WITH PRESERVED EJECTION FRACTION: MOLECULAR INSIGHTS ASSOCIATED WITH SEX DIFFERENCES IN DRUG RESPONSE
Authors: Thanh Thanh Nguyen, Min Wang, Duan Liu, Seethalakshmi Iyer, Nancy Acker, Hilda Mariana Gonzalez Bonilla, Vishakantha Murthy, Sanskriti Shrivastava, Viral Desai, John C. Burnett, Margaret M. Redfield, Richard Weinshilboum, Naveen L. Pereira
Journal: Journal of the American College of Cardiology (2022)
A RARE CASE OF VERY LATE LEAFLET THROMBOSIS AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT (TAVR)
Authors: Kapil Hemant Painter, Hamza Lodhi, Mohamed Hamed, Adithya Thomas Mathews, Harris Khan, Enrique Rodriguez-Paz, Anand Desai, Ramez Morcos, Brijeshwar Singh Maini, Houman Khalili
Journal: Journal of the American College of Cardiology (2022)
MANAGEMENT AND OUTCOME OF PATIENTS WITH NON-ST ELEVATION MYOCARDIAL INFARCTION AND INTERCURRENT NONCORONARY PRECIPITATING EVENTS
Authors: Amir Sharon, Boris Fishman, Edward Itelman, Meir Mouallem, Israel Barbash, Paul Fefer, Amit Segev, Shlomi Matetzky, Victor Guetta, Ehud Grossman, Elad Maor
Journal: Journal of the American College of Cardiology (2022)
Humoral Responses Against Variants of Concern by COVID-19 mRNA Vaccines in Immunocompromised Patients
Authors: Michel Obeid, Madeleine Suffiotti, Celine Pellaton, Hasna Bouchaab, Anne Cairoli, Vanja Salvadé, Caroline Stevenel, Rosemary Hottinger, Catherine Pythoud, Lucie Coutechier, Laura Molinari, Didier Trono, Camillo Ribi, Raphael Gottardo, Craig Fenwick, Manuel Pascual, Michel A. Duchosal, Solange Peters, Giuseppe Pantaleo
Journal: JAMA Oncology (2022)

There are limited comparative data on the durability of neutralizing antibody (nAb) responses elicited by messenger RNA (mRNA) vaccines against the SARS-CoV-2 variants of concern (VOCs) in immunocompromised patients and healthy controls.
EFFECTS OF SALT SUBSTITUTES ON BLOOD PRESSURE AND CLINICAL OUTCOMES IN DIFFERENT POPULATION GROUPS: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Xuejun Yin, Anthony Rodgers, Adam Perkovic, Liping Huang, Ka-Chun Li, Jie Yu, Yangfeng Wu, Jason Wu, Matti Marklund, J. Jaime Miranda, Gian Luca Di Tanna, Darwin Labarthe, Paul Elliott, Maoyi Tian, Bruce Charles Neal
Journal: Journal of the American College of Cardiology (2022)
Cardiorespiratory management of Duchenne muscular dystrophy: emerging therapies, neuromuscular genetics, and new clinical challenges
Authors: David J Birnkrant, Luca Bello, Russell J Butterfield, John C Carter, Linda H Cripe, Timothy P Cripe, Douglas A McKim, Deipanjan Nandi, Elena Pegoraro
Journal: The Lancet Respiratory Medicine (2022)
The N6-methyladenosine modification of circALG1 promotes the metastasis of colorectal cancer mediated by the miR-342-5p/PGF signalling pathway
Authors: Changwei Lin, Min Ma, Yi Zhang, Liang Li, Fei Long, Canbin Xie, Hua Xiao, Teng Liu, Buning Tian, Kaiyan Yang, Yihang Guo, Miao Chen, Jin Chou, Ni Gong, Xiaorong Li, Gui Hu
Journal: Molecular Cancer (2022)

Previous studies have shown that the N6-methyladenosine (m6A) modification enhances the binding ability of mRNAs/long noncoding RNAs (lncRNAs) to microRNAs (miRNAs), but the impact of this modification on the competitive endogenous RNA (ceRNA) function of circular RNAs (circRNAs) is unclear.We used a human circRNA microarray to detect the expression profiles of circRNAs in 3 pairs of cancer and paracancerous tissues from patients with colorectal cancer (CRC) and 3 pairs of peripheral blood specimens from patients with CRC and healthy individuals. The circRNAs highly expressed in both peripheral blood and tumour tissues of patients with CRC, including circALG1, were screened. A quantitative reverse-transcription polymerase chain reaction (qRT-PCR) analysis of an expanded sample size was performed to detect the expression level of circALG1 in peripheral blood and tumour tissues of patients with CRC and determine its correlation with clinicopathological features, and circRNA loop-forming validation and stability assays were then conducted. Transwell assays and a nude mouse cancer metastasis model were used to study the function of circALG1 in CRC and the role of altered m6A modification levels on the regulation of circALG1 function. qRT-PCR, western blot (WB), Transwell, RNA-binding protein immunoprecipitation (RIP), RNA antisense purification (RAP), and dual-luciferase reporter gene assays were performed to analyse the ceRNA mechanism of circALG1 and the effect of the m6A modification of circALG1 on the ceRNA function of this circRNA.CircALG1 was highly expressed in both the peripheral blood and tumour tissues of patients with CRC and was closely associated with CRC metastasis. CircALG1 overexpression promoted the migration and invasion of CRC cells, and circALG1 silencing and reduction of the circALG1 m6A modification level inhibited CRC cell migration and invasion. In vivo experiments further confirmed the prometastatic role of circALG1 in CRC. Further mechanistic studies showed that circALG1 upregulated the expression of placental growth factor (PGF) by binding to miR-342-5p and that m6A modification enhanced the binding of circALG1 to miR-342-5p and promoted its ceRNA function.M6A modification enhances the binding ability of circALG1 to miR-342-5p to promote the ceRNA function of circALG1, and circALG1 could be a potential therapeutic target in and a prognostic marker for CRC.