tbuckley/cabot-search huggingface dataset:
Cross-sectional early mitral flow-velocity profiles from color Doppler in patients with mitral valve disease.
Authors: S OSamstad, ORossvoll, H GTorp, TSkjaerpe, LHatle
Journal: Circulation (1992)

BACKGROUNDCross-sectional flow-velocity profiles from early mitral flow in 20 patients (10 with mitral regurgitation and 10 with mitral stenosis) were constructed from the velocity data from each point in sequentially delayed two-dimensional digital Doppler ultrasound maps.METHODS AND RESULTSThe data suggested that the early mitral flow studied in an apical four-chamber view was variably skewed in both patient groups. The maximum flow velocity overestimated the cross-sectional mean velocity at the same time by a factor of 1.12-1.86. The maximum time-velocity integral was 1.13-1.77-fold greater than the cross-sectional mean time-velocity integral. In patients with mitral regurgitation, the cross-sectional flow-velocity profile appeared to be most skewed at the level of the mitral leaflet tips. The level of the mitral annulus appeared to give the most homogenous flow-velocity distribution in both patient groups.CONCLUSIONSWhen calculations of volume flow are based on pulsed Doppler ultrasound recordings wit...
Body Mass Index and Risk of Second Cancer Among Women With Breast Cancer
Authors: Heather Spencer Feigelson, Clara Bodelon, J David Powers, Rochelle E Curtis, Diana S M Buist, Lene H S Veiga, Erin J Aiello Bowles, Amy Berrington de Gonzalez, Gretchen L Gierach
Journal: JNCI Journal of the National Cancer Institute (2021)

Breast cancer survivors are at increased risk for developing second primary cancers compared with the general population. Little is known about whether body mass index (BMI) increases this risk. We examined the association between BMI and second cancers among women with incident invasive breast cancer.This retrospective cohort included 6481 patients from Kaiser Permanente Colorado and Washington of whom 822 (12.7%) developed a second cancer (mean follow-up was 88.0 months). BMI at the first cancer was extracted from the medical record. Outcomes included: 1) all second cancers, 2) obesity-related second cancers, 3) any second breast cancer, and 4) estrogen receptor-positive second breast cancers. Multivariable Poisson regression models were used to estimate relative risks (RRs) and 95% confidence intervals (CIs) for second cancers associated with BMI adjusted for site, diagnosis year, treatment, demographic, and tumor characteristics.The mean age at initial breast cancer diagnosis was 61.2 (SD = 11.8) years. Most cases were overweight (33.4%) or obese (33.8%) and diagnosed at stage I (62.0%). In multivariable models, for every 5 kg/m2 increase in BMI, the risk of any second cancer diagnosis increased by 7% (RR = 1.07, 95% CI = 1.01 to 1.14); 13% (RR = 1.13, 95% CI = 1.05 to 1.21) for obesity-related cancers, 11% (RR = 1.11, 95% CI = 1.02 to 1.21) for a second breast cancer, and 15% (RR = 1.15, 95% CI = 1.04 to 1.27) for a second estrogen receptor-positive breast cancer.We observed a statistically significant increased risk of second cancers associated with increasing BMI. These findings have important public health implications given the prevalence of overweight and obesity in breast cancer survivors and underscore the need for effective prevention strategies.
Gut vascular barrier impairment leads to intestinal bacteria dissemination and colorectal cancer metastasis to liver
Authors: Alice Bertocchi, Sara Carloni, Paola Simona Ravenda, Giovanni Bertalot, Ilaria Spadoni, Antonino Lo Cascio, Sara Gandini, Michela Lizier, Daniele Braga, Francesco Asnicar, Nicola Segata, Chris Klaver, Paola Brescia, Elio Rossi, Achille Anselmo, Silvia Guglietta, Annalisa Maroli, Paola Spaggiari, Noelia Tarazona, Andres Cervantes, Silvia Marsoni, Luca Lazzari, Maria Giovanna Jodice, Chiara Luise, Marco Erreni, Salvatore Pece, Pier Paolo Di Fiore, Giuseppe Viale, Antonino Spinelli, Chiara Pozzi, Giuseppe Penna, Maria Rescigno
Journal: Cancer Cell (2021)
Hemodynamic differences between supine and upright exercise in patients with congestive heart failure.
Authors: BKramer, BMassie, NTopic
Journal: Circulation (1982)

Although the differences in hemodynamic responses to supine and upright exercise have been studied in normal subjects and in patients with angina pectoris, no such comparison has been made in patients with congestive heart failure. Many investigators measure exercise hemodynamics in heart failure patients to assess the effect of vasodilator and inotropic drugs. Both modes of exercise have been used and have often yielded differing results. We compared the hemodynamic response to supine and upright exercise in 14 patients with stable, New York Heart Association class III chronic heart failure. During upright exercise, peak heart rate was higher (124 +/- 15 vs 115 +/- 18 beats/min, p less than 0.025) and peak mean arterial pressure was lower (102 +/- 15 vs 95 +/- 17 mm Hg, p less than 0.25), yielding similar double products. Although the peak left ventricular filling pressure was slightly lower during upright exercise (40 +/- 7 vs 35 +/- 10 mm Hg, p less than 0.05), the maximum cardiac and stroke indexes we...
Microscopic conduction in cultured strands of neonatal rat heart cells measured with voltage-sensitive dyes.
Authors: V GFast, A GKléber
Journal: Circulation Research (1993)

Microscopic discontinuities in electrical activation were assessed in synthetic strands of neonatal rat myocytes cultured on a growth-directing matrix. An optical method using voltage-sensitive dye (RH-237) and a photodiode technique was used for recordings of membrane potential changes with subcellular resolution. Spatial resolution of the method (diameter of measurement area, 5.5 microns; interdiode distance, 30 microns) allowed for simultaneous measurements of cytoplasmic conduction time within a single cell and junctional conduction time across the cell border. In one-dimensional cell chains, where cells were juxtaposed by end-to-end connections but devoid of lateral connections, propagation of the excitation wave was strongly nonuniform: cytoplasmic conduction time was 38 +/- 30 (mean +/- SD) microseconds (n = 37), whereas junctional conduction time was 118 +/- 40 microseconds (n = 27, P < .0001). A mean delay introduced by a single junction was 80 microseconds, or 51% of conduction time. In two-dime...
Dietary iron intake and risk of coronary disease among men.
Authors: AAscherio, W CWillett, E BRimm, E LGiovannucci, M JStampfer
Journal: Circulation (1994)

BACKGROUNDWe prospectively studied iron intake in relation to the incidence of coronary disease in a 4-year follow-up of 44,933 men (with no previous history of cardiovascular disease) aged 40 to 75 years in 1986 who completed a food frequency questionnaire at baseline.METHODS AND RESULTSWe documented 844 incident cases of coronary disease (249 nonfatal myocardial infarctions, 137 coronary disease fatalities, and 458 bypass operations or angioplasties). After adjustment for established risk factors, there was no significant association between total iron intake and risk of coronary heart disease. Men in the highest quintile of total intake (median, 37 mg/d) had a relative risk (RR) of fatal coronary disease or nonfatal myocardial infarction of 0.73 (95% confidence intervals [CI], 0.51, 1.06) compared with men in the lowest quintile of intake (median, 11 mg/d). Dietary intake of heme iron--mainly from red meat--also was not significantly associated with risk of coronary heart disease. However, incidence of...
High-Flow vs Conventional Oxygen Therapy and Risk of Reintubation
Authors: Gaspard Cadier, Stanislas de Guillebon, Alexandre Boyer
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Developmental changes in the effects of lidocaine on the electrophysiological properties of canine Purkinje fibers.
Authors: YMorikawa, M RRosen
Journal: Circulation Research (1984)

Developmental changes in the cardiac effects of antiarrhythmic drugs have been noted in the clinical setting. To study whether these might in part be based on developmental differences in drug effects on the transmembrane potential, we used standard microelectrode techniques to study the effects of lidocaine on the transmembrane potentials of Purkinje fibers from adult and young dogs. Control studies of membrane responsiveness and steady state recovery kinetics of Vmax showed no age-related differences in these variables. Lidocaine reduced Vmax of adult fibers to a greater extent than that of young fibers at basic drive cycle lengths of 1000 and 400 msec. The number of beats to reach steady state Vmax at basic drive cycle length of 400 msec was smaller in adult than in young fibers. Both tonic and use-dependent block appeared to be greater and to develop more rapidly in the adult than the young fibers. Moreover, fibers from young dogs recovered more rapidly from the effects of lidocaine than did adult fib...
Covid-19 vaccines save lives
Authors: Beate Kampmann, Sandra Mounier Jack
Journal: BMJ (2021)

Heroin misuse in pregnancy is a significant health and social problem, and it can have an adverse effect on the mother and the baby. Although heroin and methadone have no specific teratogenic potential, 48–94% of children exposed in utero will have neonatal abstinence syndrome (NAS). The primary aim of this case report is to raise awareness of NAS among clinicians and to remind them that although very common, it is not inevitable. The risk of NAS can be further minimised by offering comprehensive and co-ordinated antenatal care that addresses the various biopsychosocial needs of the pregnant woman. Further, a brief description of NAS and a review of evidence in the field of management of opioid misuse in pregnancy, as relevant to this case, are provided. We have also included the patient’s own reflections on her pregnancy and treatment.
The transmitral pressure-flow velocity relation. Effect of abrupt preload reduction.
Authors: MCourtois, ZVered, BBarzilai, N ARicciotti, J EPérez, P ALudbrook
Journal: Circulation (1988)

Although recent animal and clinical studies suggest that Doppler-derived indexes may be useful for the characterization of ventricular diastolic behavior, the hemodynamic basis for the preload dependency of these indexes has not previously been fully elucidated. Accordingly, effects of reduction of left atrial load on the pressure-flow velocity relation were characterized in 10 anesthetized, closed-chest dogs during transient inferior vena caval occlusion by means of simultaneously recorded left atrial and left ventricular micromanometric pressure measurement and transesophageal Doppler echocardiograms. Within four or five beats after inferior vena caval balloon occlusion, left atrial loading was reduced as evidenced by a decrease in the slope of the left atrial v wave from 21 +/- 4 to 13 +/- 4 mm Hg/sec (p less than 0.001) and by a decrease in the first crossover point of left atrial and left ventricular pressures from 5.6 +/- 1.1 to 2.9 +/- 1.5 mm Hg (p less than 0.001). This decrease in left atrial loa...
Significance of chromosome 2p gain in ibrutinib-treated chronic lymphocytic leukemia patients
Authors: Cecelia R. Miller, Ying Huang, Amy S. Ruppert, Jadwiga Labanowska, Samantha M. Jaglowski, Kami J. Maddocks, Kerry A. Rogers, Seema Bhat, Adam S. Kittai, Michael Grever, Rosa Lapalombella, Lynne V. Abruzzo, Nyla A. Heerema, John C. Byrd, Erin K. Hertlein, Jennifer A. Woyach
Journal: Leukemia (2021)
Safety and Efficacy of Ustekinumab in the Inflammatory Bowel Disease of Chronic Granulomatous Disease
Authors: Sumona Bhattacharya, Beatriz E. Marciano, Harry L. Malech, Martha Quezado, Steven M. Holland, Suk See De Ravin, Christa S. Zerbe, Theo Heller
Journal: Clinical Gastroenterology and Hepatology (2021)
Effect of hyaluronidase and methylprednisolone on myocardial function, glucose metabolism, and coronary flow in the isolated ischemic rat heart.
Authors: M JRovetto
Journal: Circulation Research (1977)

Ischemia in the isolated perfused rat heart resulted in an increase in coronary vascular resistance. Studies were undertaken to determine the effect of hyaluronidase and methylprednisolone on this increase in resistance as well as on glycolytic rate and mechanical function of ischemic hearts. Neither hyaluronidase nor methylprednisolone affected the rate of glucose utilization in working perfused control or ischemic rat hearts. However, both agents prevented a reduction in coronary flow during a 2-hour ischemic period. Associated with the higher coronary flows were higher tissue concentrations of creatine phosphate and lower concentrations of lactate. These agents also prevented accumulation of tissue water in the ischemic hearts. Such changes would appear to be beneficial to the ischemic heart, although mechanical function of post-ischemic hearts was not enhanced by the presence of either hyaluronidase or methylprednisolone. The results, however, suggest that the reduction in myocardial infarct size note...
The vasopressor response to centrally administered ouabain.
Authors: R WCaldwell, ESongu-Mize, S LBealer
Journal: Circulation Research (1984)

Ouabain (80 micrograms/kg) injected into the lateral cerebroventricles (ICV) of rats produced a prompt and sustained increase in arterial blood pressure. A diastolic blood pressure increase of about 40 mm Hg began within 10 minutes of injection and lasted at lest 1 hour. This dose of ouabain had no effect on arterial pressure when given intravenously. The vasopressor response to intracerebroventricularly administered ouabain was not blocked by prior intravenous administration of phentolamine (1 mg/kg) or hexamethonium (3 mg/kg). However, continuous intravenous infusion of saralasin (2 micrograms/kg per min) prevented the pressor response to intracerebroventricularly administered ouabain. In addition, bilateral nephrectomy, adrenalectomy, pretreatment with intravenously administered propranolol (2 mg/kg) or captopril (10 mg/kg) abolished the increase in blood pressure evoked by intracerebroventricularly administered ouabain. Plasma renin and epinephrine levels at the peak of the pressor response to intrace...
Managed Care: Ethical Issues
Authors: Fred Rosner
Journal: JAMA (1995)

To the Editor.  —A recent Editorial 1 in JAMA criticizes the American Medical Association Council on  and Judicial Affairs report, Ethical Issues in Managed Care, 2 for failing to come to terms with the inherent tension between caring for patients and the physician's role in resource allocation.  Most people underestimate the magnitude of the conflict between a physician functioning under traditional medical ethics and the same physician functioning under a managed care system. Dr Pellegrino emphasizes the irreducibility of conflict between cost-driven, as opposed to care-driven, health care policy. Delays in care, postponement of consultation or hospitalization... impersonality, loss of dignity, and magnification of suffering... influence the quality of care, degree of satisfaction, and functional capacity of the ill, 3 but are not easily resolvable issues under a managed care system. These are the care issues and cannot be ignored in a cost-controlled system.  No one disputes that ethical
Aggressive Lipid-Lowering Therapy and Regression of Coronary Atheroma
Authors: Kavitha Rajaram
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Failure of chronic sodium chloride loading to protect against norepinephrine-induced acute renal failure in dogs.
Authors: R WBaehler, T AKotchen, C EOtt
Journal: Circulation Research (1978)

We previously have shown that chronic sodium chloride (NaCl) loading protects against HgCl2-induced acute renal failure (ARF) in dogs. To determine whether NaCl loading protects against an ischemic model of ARF, unilateral oliguric renal failure was produced by the infusion of norepinephrine (NE) into the renal artery of both saline-expanded (SE) and water-drinking (WD) dogs (n = 7). The renal renin content (30 U/g kidney) of SE dogs was suppressed (P less than 0.001) compared to that of WD dogs (132 +/- 18). Forty-eight hours after infusion of NE (1.5 microgram/kg per min X 100 min), inulin clearances from the infused kidney of SE (6 ml/min +/- 2) and WD dogs (7 +/- 2) did not differ; in both groups, respective clearances from the noninfused kidney (43 ml/min +/- 3) and (36 +/- 5) also did not differ from each other. The present fall in renal blood flow to the infused kidney 48 hours after NE in SE (44%) and WD dogs (38%) did not differ. Because of failure to demonstrate protection, a lower dose of NE (0...
Incorporating redox-sensitive nanogels into bioabsorbable nanofibrous membrane to acquire ROS-balance capacity for skin regeneration
Authors: Shihao Zhang, Yamin Li, Xiaofeng Qiu, Anqi Jiao, Wei Luo, Xiajie Lin, Xiaohui Zhang, Zeren Zhang, Jiachan Hong, Peihao Cai, Yuhong Zhang, Yan Wu, Jie Gao, Changsheng Liu, Yulin Li
Journal: Bioactive Materials (2021)

Facing the high incidence of skin diseases, it is urgent to develop functional materials with high bioactivity for wound healing, where reactive oxygen species (ROS) play an important role in the wound healing process mainly
Increased heart rate prevents the isomyosin shift after cardiac transplantation in the rat.
Authors: D LGeenen, AMalhotra, P MButtrick, JScheuer
Journal: Circulation Research (1992)

The heterotopically transplanted rat heart undergoes significant atrophy and a shift from V1 to V3 isomyosin. The purpose of this study was to pace the cardiac isograft and determine whether an increase in heart rate would attenuate the changes in cardiac mass and isoenzyme distribution. Nonpaced transplanted hearts were compared with hearts in which pacing was initiated at 7 Hz, 24 hours after transplantation, and continued for 7 days. There was a 29% decrease in myosin ATPase activity and a 22% decrease in alpha-myosin in the nonpaced isograft; both decreases were completely prevented by pacing. The decrease in cardiac mass was also significantly attenuated. Pacing did not alter intrinsic heart rate, systolic pressure, dP/dt, or norepinephrine concentration in the isograft. These results suggest that the adaptation in both cardiac mass and isoenzymes may be related to the rate or the rate-pressure product in the transplanted paced heart independent of left ventricular pressure, tissue catecholamines, or...
Relation of arteriographically defined coronary artery disease to serum lipoprotein particles mapped with monoclonal antibodies.
Authors: CFiévet, M CNuttens, PDucimetière, J CFruchart, MBertrand, J LSalomez
Journal: Circulation (1991)

BACKGROUNDThis study was designed to investigate the relation of a molecular analysis of apolipoprotein B (apoB)-containing atherogenic lipoprotein particles to coronary artery disease (CAD) in middle-aged men.METHODS AND RESULTSTwo groups of men were studied. The first consisted of 97 patients with angiographically documented CAD (greater than 50% stenosis of at least one coronary artery). The second group consisted of 145 subjects without symptomatic CAD, who served as controls. In both groups, measurements were obtained for total cholesterol level, triglyceride level, cholesterol contents in apoB- and nonapoB-containing particles (LpB, LpnonB), total apoB and apolipoprotein AI (apoAI levels), lipoprotein particles recognized by monoclonal antibodies anti-apoB (LpBL3, LpBL5, LpBL7) and anti-apoAI (LpAI-2GII). Taking into account age, body mass index, hypertension, diabetes, smoking habits, and drug consumption, the analysis showed that the mean levels of cholesterol were identical in both groups but dif...
Characteristics of rat aortic baroreceptors with nonmedullated afferent nerve fibers.
Authors: PThorén, W RSaum, A MBrown
Journal: Circulation Research (1977)

Nervous activity was recorded from nonmedullated afferent baroreceptor fibers in the left aortic nerve of normotensive rats. The aortic arch was perfused in vitro with oxygenated Krebs-Henseleit solution. Two different patterns of aortic C fiber discharge were found. One type (5 of 29 fibers) had a regular discharge at constant pressure whereas the other type had an irregular discharge. The differences between the two types were independent of the mean steady state rates of discharge. The average threshold pressure for the receptors with the regular discharge was 87 mm Hg (range, 65-125); it was 152 mm Hg (range, 85-260) for the irregularly discharging receptors. During a pressure step the receptors in either group normally showed an initial high frequency burst of activity and a sustained discharge which had a lower frequency. Furthermore, the peak discharge and the sustained discharge were lower on the average in the receptors with the irregular type of firing. We also found that addition of norepinephr...