tbuckley/cabot-search huggingface dataset:
Abstract 17070: Engineering a Novel Ex Vivo Heart Simulator for Biomechanical Analysis of the Aortomitral Junction
Authors: Matthew H Park, Annabel Imbrie-moore, Yuanjia Zhu, Hanjay Wang, Michael J Paulsen, Y Joseph Y Woo
Journal: Circulation (2020)

Introduction: Advances in ex vivo heart simulation have enabled the study of valvular biomechanics, disease pathologies, and repair strategies. However, these simulators test the valves in isolation, which does not fully replicate in vivo physiology. We hypothesize that by engineering a simulator that preserves the aortomitral junction, we can better recreate pathophysiologies such as systolic anterior motion (SAM). Here, we present a new heart simulator that preserves and manipulates the native aortomitral physiology. Methods: Our simulator is comprised of three subsystems: the ventricular chamber, atrial chamber, and aortic chamber (Fig A, B). The heart is excised at the apex to preserve the papillary muscles, and the left ventricle, atrial cuff, and aorta are fixed to their respective chambers via hemostatic suturing to 3D-printed elastomeric rings. The chambers are equipped with pressure and flow sensors, and a linear piston pump generates physiologic pressures and flows. The atrial and aortic chambers are mounted on 5-degree-of-freedom arms. To demonstrate system function, we manipulated the aortomitral angle and measured aortic cardiac output. Results: In our testing, we evaluated two unique configurations of an explanted porcine heart, of which the aortomitral angles spanned the SAM predictive risk threshold of &lt;120° (Fig C, D). From the flow readings, we measured a 36% reduction in aortic cardiac output upon decreasing the aortomitral angle by 25°. Conclusions: This work highlights the design and development of an ex vivo heart simulator capable of modeling native aortomitral physiology. Our results point to a clear direction for future experimentation, particularly evaluating the biomechanical changes of the heart based on the aortomitral angle. Future work will utilize this platform to create new models and repair techniques to ultimately improve clinical care of valvular pathologies.
Abstract 13100: Rescue Myocardial Aging Caused a Progressive Decline in Cardiac Function and β-Adrenergic Reserve With a Selective Beta3-Adrenergic Receptor Antagonist, but Not Beta1-Adrenergic Receptor Blocker in a Murine Model
Authors: Che Cheng, Xiaoqiang Sun, Jing Cao, Yixi Liu, Zhe Chen, Peng Zhou, Satoshi Masutani, Dalane Kitzman, David Zhao, Heng Jie Cheng
Journal: Circulation (2020)

Background: Cardiac aging (CA) leads to the progressive decline in cardiac function- increasing risk for heart failure (HF) and cardiac mortality. Both down-regulation of β 1 -adrenergic receptors (AR) and up-regulation of a newly-described inhibitory pathway mediated by β 3 -AR may play a crucial role in the development of CA. β-AR blockers are a mainstay in the therapy of several cardiovascular diseases, including HF. However the therapeutic effects of different β blockers in CA are unknown. We tested the hypothesis that up-regulation of cardiac β 3 -AR with enhanced negative inotropic actions, rather than the desensitization of β 1 -AR, is the critical determinant of the dysfunctional β-AR regulation that occurs in CA. Thus, β 3 -AR antagonists (β 3 ANT), but not β 1 Blockade, may reverse the progression of age-associated deficits in LV myocyte functional performance. Methods: LV myocyte basal and isoproterenol (ISO)-stimulated functional and [Ca 2+ ] i transient ([Ca 2+ ] iT ) responses were compared in 4 groups (7/group) of wild-type (WT) mice: 1) YWT , young (Y, 6 mo); 2) Aβ 3 ANT , aged (A, 26 mo) treated with β 3 ANT (L-748,337, 10 -7 M/kg/day, mini-pump) for 12 weeks (W);3) Aβ 1 Blockade , metoprolol XL (1.5 mg/kg/day, po), a selective β 1 blocker was given for 12 W and 4) AWT , aged sham control. Results: Compared with YWT, AWT myocytes had about 30% decreases in basal cell contraction (dL/dt max , 85.9 vs 122.3 μm/s) and relaxation (dR/dt max , 69.4 vs 99.2 μm/s) with reduced the peak [Ca 2+ ] iT (0.17 vs 0.21). ISO (10 -8 M)-stimulated increases in dL/dt max (33% vs 69%), dR/dt max (31% vs 62%) and [Ca 2+ ] iT (15% vs 34%) also significantly reduced. In Aβ 1 Blockade group, metoprolol therapy failed to improve basal dL/dt max (86.3 μm/s), dR/dt max (68.9 μm/s) and [Ca 2+ ] iT (0.18). ISO-stimulated increases in dL/dt max (34%), dR/dt max (35%) and [Ca 2+ ] iT (17%) remained attenuated. By contrary, Aβ 3 ANT myocytes showed normal basal cell contraction (131.0 μm/s), relaxation (101.9 μm/s) and [Ca 2+ ] iT (0.21) with preserved ISO-stimulated increases in dL/dt max (68%), dR/dt max (59%) and [Ca 2+ ] iT (32%). Conclusions: Chronic β 3 -AR antagonist, but not β 1 -AR blocker leads to the preservation of myocyte function, [Ca 2+ ] iT , and β-adrenergic responsiveness in a murine model of cardiac aging.
Cemiplimab in locally advanced basal cell carcinoma after hedgehog inhibitor therapy: an open-label, multi-centre, single-arm, phase 2 trial
Authors: Alexander J Stratigos, Aleksandar Sekulic, Ketty Peris, Oliver Bechter, Sorilla Prey, Martin Kaatz, Karl D Lewis, Nicole Basset-Seguin, Anne Lynn S Chang, Stèphane Dalle, Almudena Fernandez Orland, Lisa Licitra, Caroline Robert, Claas Ulrich, Axel Hauschild, Michael R Migden, Reinhard Dummer, Siyu Li, Suk-Young Yoo, Kosalai Mohan, Ebony Coates, Vladimir Jankovic, Nathalie Fiaschi, Emmanuel Okoye, Ioannis D Bassukas, Carmen Loquai, Vincenzo De Giorgi, Zeynep Eroglu, Ralf Gutzmer, Jens Ulrich, Susana Puig, Frank Seebach, Gavin Thurston, David M Weinreich, George D Yancopoulos, Israel Lowy, Timothy Bowler, Matthew G Fury
Journal: The Lancet Oncology (2021)
Roderick William Somerville Brooks
Authors: Gillian Brooks, Peter Mayer
Journal: BMJ (2021)

Roderick William Somerville Brooks was born in the West Country and qualified from Bristol University in 1976. During his training he worked with Geoffrey Burston, who instilled him that older people often have the ability to improve from awful illness, that they always have an interesting story to tell because they have been around on the planet long enough, and that working within a multidisciplinary team even the most stubborn “sow’s ear” can be turned into at least a serviceable “silk purse.”

He had a lifelong involvement with Forest School Camps, an educational charity that takes children light weight camping. At 21, when he was a …
RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells
Authors: Taisho Yamada, Seiichi Sato, Yuki Sotoyama, Yasuko Orba, Hirofumi Sawa, Hajime Yamauchi, Michihito Sasaki, Akinori Takaoka
Journal: Nature Immunology (2021)
Abstract 13025: Methotrexate Carried in Lipid Core Nanoparticles Prevented the Dilation and Dissection of the Aortic Arch in Mice With Marfan Syndrome by Increasing the Bioavailability of Intracellular Adenosine
Authors: Maria Carolina Guido, Natalia M Lopes, Camila I Albuquerque, Elaine R Tavares, Leonardo Jensen, Lygia V Pereira, Francisco R Laurindo, Raul C Maranhao
Journal: Circulation (2020)

Introduction: Mutations in the fibrillin-1 gene result in aneurysms and rupture of the aorta, the main cause of mortality in patients with Marfan syndrome (MFS). Inflammation is associated with dissection and rupture of the aorta. We showed that methotrexate (MTX) carried in lipid core nanoparticles (LDE) had powerful anti-inflammatory effects on atherosclerotic lesions and myocardial infarction. Hypothesis: To investigate whether treatment with LDE-MTX can prevent the development of aortic arch lesions in MFS. Methods: mgΔloxPneo MFS murine model and wild-type mice were allocated in 3 groups of treatment: LDE only; MTX in commercial formulation; LDE-MTX. The treatment occurred weekly at a dose of 1mg/kg ip, between the 3rd and 6th month of life, period in which both dilation and dissection of the aortic arch are observed. After 12 weeks, animals were submitted to analysis of the aortic arch. Results: Compared to LDE and MTX groups, LDE-MTX treatment showed smaller lumen area of ascending and descending aorta and aortic arch segments in MFS mice. LDE-MTX also decreased collagen volume fraction and the amount of aortic dissections, but did not affect the thickness of the vessel wall and the number of elastic fiber ruptures. Protein expression of the inflammatory markers CD68 (macrophages), CD3 (lymphocytes) and tumor necrosis factor alpha, of the apoptotic marker caspase 3 and of type 1 collagen were lower in LDE-MTX group when compared to LDE and MTX. Moreover, treatment with LDE-MTX reduced TGF-β, ERK and SMAD3 protein expression. Of note, CD68 and CD3 protein expression were positively correlated with the lumen area of the aortic arch (r2=0.36; p&lt;0.001), indicating the importance of inflammation for the aortic dilation. The increase in bioavailability of intracellular adenosine was suggested by higher expression of A2a adenosine receptor and lower levels of adenosine deaminase in the aortic arch. Conclusions: Possibly by increasing the bioavailability of intracellular adenosine, LDE-MTX treatment had the ability to reduce the processes of inflammation, apoptosis and fibrosis that are consequent to fibrillin-1 mutation. By these means, LDE-MTX may conceivably prevent the development of the dilation and dissection in the aortic arch, the hallmarks of MFS.
Endothelial Dysfunction after Percutaneous Coronary Intervention-Is it Different According to the Kind of Stent?-
Authors: Maruhashi Tatsuya, Teragawa Hiroki, Mitsuba Naoya, Mikami Shinsuke, Ishibashi Ken, Nishioka Kenji, Soga Junko, Fujii Yuichi, Okada Takenori, Shokawa Tomoki, Nakano Yukiko, Tadehara Futoshi, Yamamoto Hideya, Ishida Takafumi, Higashi Yukihito, Kihara Yasuki
Journal: Circulation (2010)
LBA4 Datopotamab deruxtecan (Dato-DXd), a TROP2-directed antibody-drug conjugate (ADC), for triple-negative breast cancer (TNBC): Preliminary results from an ongoing phase I trial
Authors: A. Bardia, D. Juric, T. Shimizu, A. Tolcher, R. Karim, A. Spira, T. Mukohara, A.E. Lisberg, T. Kogawa, I. Krop, K.P. Papadopoulos, E. Hamilton, S. Damodaran, J. Greenberg, W. Gu, F. Kobayashi, F. Guevara, T. Jikoh, Y. Kawasaki, F. Meric-Bernstam
Journal: Annals of Oncology (2021)
Constant Infusion of Diltiazem in Acute Congestive Heart Failure with Atrial Tachyarryhthmia and Impaired Systolic function Is Safe and Effective
Authors: Ohishi Shogo, Shimane Akira, Chimura Misato, Saita Ten, Takahashi Hachidai, Aoki Kosuke, Toba Takayoshi, Teranishi Jin, Miyoshi Naoki, Tsukishiro Yasue, Yokoi Kiminobu, Kanda Gaku, Takaya Tomofumi, Fukuzawa Koji, Kobayashi Seiichi, Okajima Katsunori, Yamada Shinichiro, Taniguchi Yasuyo, Hayashi Takatoshi, Yokoyama Mitsuhiro
Journal: Circulation (2012)
Abstract 14868: Promises of Transcatheter Tricuspid Valvular Interventions in Patients With Clinically Significant Tricuspid Regurgitation: A Meta-analysis
Authors: Kaveh Rezaei Bookani, Nso Nso, Farshid Radparvar, Mark Ricciardi
Journal: Circulation (2020)

Introduction: Clinically significant tricuspid regurgitation is common especially in patients with structural heart disease and is independently associated with poor outcomes. Several transcatheter interventions for tricuspid valve repair are under investigation. We aimed to illustrate and summarize the efficacy and safety of these interventions. Methods: We conducted a literature search for relevant clinical registries and trials published until April 2020. We searched PubMed, Scopus, Web of Science, and Cochrane CENTRAL. We performed the analysis of continuous outcomes using the mean difference (MD) while used the risk ratio (RR) for analysis of dichotomous outcomes. We included the following outcomes: Tricuspid annular plane systolic excursion (TAPSE), Vena Contracta (VC), Tricuspid Annulus diameter (TAD), Tricuspid regurgitation volume (TRV), Left ventricular ejection fraction (LVEF), and mortality rates. The random-effects model was used for the analysis of heterogeneous data, while homogeneous data were analyzed under the fixed-effects model. Results: We obtained fifteen clinical registries/trials and included a total of 1329 patients. We found that tricuspid valve interventional devices improved LVEF (MD = 1.46%, 95% CI [0.45, 2.47], p=0.005), led to smaller VC (MD = -4.69, 95% CI [-5.50, -3.88], p=0.005), lower TRV (MD = -11.68, 95% CI [-21.25, -2.11], p=0.02), and smaller TAD (MD = -3.78mm, 95% CI [-5.09, -2.47], p&lt;0.001). No significant difference was noted regarding TAPSE (MD=0.07mm, 95% CI [-0.29, 0.44], p=0.7). Results of the six minutes walking test showed that patients could walk 40 more meters after intervention (MD = 40.64, 95% CI [23.89, 57.40], p&lt;0.001). Pooled mortality rate was 8.2%, stroke 1%, and bleeding 5% during the mean 12 months follow up. Conclusions: Transcatheter tricuspid valve repair devices prove to be effective interventions in decreasing regurgitation and improving functional capacity in patients with clinically significant TR. Mortality (8% during mean 12 months follow up) seems to be related to underlying cardiovascular disease.
Abstract 16624: Gender Disparities Based on Time to Revascularization in the Treatment of Non-st-segment Elevation Myocardial Infarction: An Analysis of 748,439 Nstemi Admissions
Authors: Charan Yerasi, Brian C Case, Yanying Wang, Brian Forrestal, Joshua Hahm, Sarahfye Dolman, William S Weintraub, Ron Waksman
Journal: Circulation (2020)

Background: Multiple studies on Non-ST-segment elevation myocardial infarction (NSTEMI) have shown that women tend to have delayed revascularization, with associated worse outcomes, when compared to men. However, there are no studies to date, evaluating the clinical characteristics and outcomes of men versus (vs.) women based on time to revascularization. Methods: The study cohort was obtained from the 2016 Nationwide Readmissions Database. We used the International Classification of Diseases, Tenth Revision, to identify patients who underwent diagnostic angiography and subsequently received either percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). Finally, mortality and 30-day readmissions rates based on gender and time to revascularization were extracted. Results: In 2016, there were a total of 748,439 weighted admissions for NSTEMI (57% men and 43% women). Compared to men, women were older and had higher percentage of baseline comorbidities. Women tended to be managed less invasively with only 45% undergoing coronary angiogram as compared to 54% in men (p&lt;0.001). Furthermore, there was a difference in revascularization rates, PCI (men 30% vs. women 21%, p&lt;0.001) or CABG (men 10% vs. women 5%, p&lt;0.001). Majority of men (34%) were revascularized by PCI on same day, while majority of women (30%) were revascularized next-day of admission. In both men and women, patients with more comorbidities tend to have delay in revascularization. Compared to men, in-hospital mortality and 30-day readmission is higher in women as the revascularization is delayed (Figure 1). Conclusions: Currently, there exists wide disparity among men and women in the treatment of NSTEMI. Women tend to have worse outcomes as the revascularization gets delayed. Randomized clinical trials are needed to evaluate if a strategy of urgent revascularization (&lt;90 minutes) in women is associated with improved outcomes.
Abstract 15580: The Impact of Sex and Gender-related Factors on Length-of-stay Following NSTEMI: A Multicountry Analysis
Authors: Uri Bender, Colleen M Norris, Valeria Raparelli, Tadiri Christina, Louise Pilote
Journal: Circulation (2020)

Introduction: Gender refers to psycho-socio-cultural characteristics typically ascribed to men, women and gender-diverse individuals and has been shown to be associated with adverse clinical outcomes in AMI independent of sex. Substantial heterogeneity in hospital length of stay exists among patients admitted with NSTEMI. Whether sex and gender-based differences contribute to length-of-stay (LOS) among patients with NSTEMI remains unknown. Methods: To examine the relationship between sex, gender-related factors and LOS in adults hospitalized for NSTEMI, data from the GENESIS-PRAXY (n=1,210, Canada, U.S. and Switzerland), EVA (n=430, Italy) and VIRGO (n=3,572, U.S., Spain and Australia) studies of adults hospitalized for AMI were combined and analyzed. A best-fit linear regression model was selected through incremental analysis by stepwise addition of gender-related variables thought to be different in either impact or distribution between men and women. Results: Among the overall cohort (n=5,212), 2,218 participants with a diagnosis of NSTEMI were included in the final cohort (66% women, mean age 48.5 years, 67.8% U.S.). Half of the patients had a LOS of longer than 4 days (n=1,124) and were more likely to be white and have a clustering of cardiac risk factors in comparison to those with shorter LOS. No association between sex and LOS was observed in the bivariate analysis (p=0.87). In the multivariable model adjusted for sex, age, country of hospitalization, level of education, marital status, employment status, income, and social support, age (0.062 days/year, p=0.0002), being employed (-0.63 days in workers, p=0.01) and the treatment country relative to Canada (Italy=4.1 days; Spain=1.7 days; and the U.S.=-1.0 days, all p-value&lt;0.001) were significant predictors of LOS. Conclusions: Employed individuals are more likely to experience a shorter LOS following NSTEMI. Variation in LOS exists across different countries and is likely due to institutional policy, resource allocation, and differences in cultural and psychosocial influences.
Abstract P103: Association Of Lipid Variability With Incident Alzheimers Disease And Alzheimers Disease Related Dementias
Authors: Ethan D Moser, Sheila M Manemann, Nicholas B Larson, Jennifer L St Sauver, Paul Y Takahashi, Michelle M Mielke, Walter A Rocca, Janet E Olson, Veronique L Roger, Paul A Decker, Jill M Killian, Suzette J Bielinski
Journal: Circulation (2021)

Background: Prevention strategies for Alzheimer’s disease and Alzheimer’s disease related dementias (AD/ADRDs) are urgently needed for reducing incidence. Intra-patient variability in lipid levels is a potentially modifiable risk factor for incident AD/ADRD. Although regular lipid measurements are a part of common clinical practice and longitudinal data routinely available in electronic health records (EHR), research examining this association between AD/ADRD and lipid variability across multiple lipid types remains scarce. Methods: All residents living in Olmsted County, MN on 1/1/2006 age ≥60 years without an AD/ADRD diagnosis were identified using Centers for Medicare &amp; Medicaid Services diagnostic codes. Persons with ≥3 lipid measurements (total cholesterol or triglycerides) in the 5 years prior to index date were retained. Lipid variability was quantified using variability independent of the mean (VIM). Models were adjusted for traditional risk factors. Associations between lipid variability quintiles and incident AD/ADRD were assessed using Cox proportional hazards regression. Multiple imputation was used for missing covariates. Participants were followed through 2018 for incident AD/ADRD. Results: The final analysis included data on 11,551 participants with total cholesterol and 11,502 participants with triglycerides. Participants had a mean age of 71 (range 60-99) years, and were primarily white (96%). Females (54%) were also slightly more frequent than males. Median follow up was 12.9 years (range: 0-13). Participants in the highest quintile of variability for total cholesterol and triglycerides had a 20% increased risk of incident AD/ADRD. Similar results were found in the subset with complete covariate data. Conclusion: In a large EHR derived cohort, persons in the highest quintile of lipid variation had an increased risk of incident AD/ADRD. Further studies to identify the mechanisms behind this risk factor and replication of these results across a more diverse population are needed.
Mask Use and Ventilation Improvements to Reduce COVID-19 Incidence in Elementary Schools — Georgia, November 16–December 11, 2020
Authors: Jenna Gettings, Michaila Czarnik, Elana Morris, Elizabeth Haller, Angela M. Thompson-Paul, Catherine Rasberry, Tatiana M. Lanzieri, Jennifer Smith-Grant, Tiffiany Michelle Aholou, Ebony Thomas, Cherie Drenzek, Duncan MacKellar
Journal: MMWR Morbidity and Mortality Weekly Report (2021)

COVID-19 incidence was 37% lower in schools that required teachers and staff to use masks and 39% lower in schools that improved ventilation. Ventilation strategies associated with lower school incidence included dilution methods alone (35% lower incidence) or in combination with filtration methods (48% lower incidence).
Treatment Patterns and Health/Economic Outcomes in Relapsed/Refractory Follicular Lymphoma: A Real-World Study
Authors: Richard van der Jagt, Caroline Hamm, Isabelle Fleury, Véronique Lambert-Obry, Avril Gouault Laliberté, Alex Castonguay, Dennis Wagner, Lisa Toltl, Jean Lachaine
Journal: Blood (2017)
Islatravir in combination with doravirine for treatment-naive adults with HIV-1 infection receiving initial treatment with islatravir, doravirine, and lamivudine: a phase 2b, randomised, double-blind, dose-ranging trial
Authors: Jean-Michel Molina, Yazdan Yazdanpanah, Alejandro Afani Saud, Christopher Bettacchi, Carolina Chahin Anania, Edwin DeJesus, Stephanie Olsen Klopfer, Anjana Grandhi, Karen Eves, Michael N Robertson, Todd Correll, Carey Hwang, George J Hanna, Peter Sklar
Journal: The Lancet HIV (2021)
Social media use and self-injurious thoughts and behaviors: A systematic review and meta-analysis
Authors: Jacqueline Nesi, Taylor A. Burke, Alexandra H. Bettis, Anastacia Y. Kudinova, Elizabeth C. Thompson, Heather A. MacPherson, Kara A. Fox, Hannah R. Lawrence, Sarah A. Thomas, Jennifer C. Wolff, Melanie K. Altemus, Sheiry Soriano, Richard T. Liu
Journal: Clinical Psychology Review (2021)
162P Unique challenges and outcomes of young breast cancers from a tertiary care cancer centre in India
Authors: J. Bajpai, V. Pradeep, R. Nandhana, S. Mohanty, Q. Chougle, M.A. Engineer, S. Rath, S. Joshi, T. Wadasadawala, P. Popat, R. Pathak, S. Gulia, J. Ghosh, P.G. Bhargava, S. Srinivas, T. Shet, R. Sarin, R. Badwe, S. Gupta
Journal: Annals of Oncology (2021)