tbuckley/cabot-search huggingface dataset:
Benchmarking sequencing methods and tools that facilitate the study of alternative polyadenylation
Authors: Ankeeta Shah, Briana E. Mittleman, Yoav Gilad, Yang I. Li
Journal: Genome biology (2021)

Alternative cleavage and polyadenylation (APA), an RNA processing event, occurs in over 70% of human protein-coding genes. APA results in mRNA transcripts with distinct 3' ends. Most APA occurs within 3' UTRs, which harbor regulatory elements that can impact mRNA stability, translation, and localization.
Extracellular Matrix‐Based Conductive Interpenetrating Network Hydrogels with Enhanced Neurovascular Regeneration Properties for Diabetic Wounds Repair
Authors: Lei Fan, Cairong Xiao, Pengfei Guan, Yan Zou, Huiquan Wen, Can Liu, Yian Luo, Guoxin Tan, Qiyou Wang, Yangfan Li, Peng Yu, Lei Zhou, Chengyun Ning
Journal: Advanced Healthcare Materials (2021)

The critical effects that impair diabetic wound healing are characterized by poor vascularization and severe peripheral neuropathy. Current management strategies for diabetic wound healing are unsatisfactory, due to the paucity of neurovascular regeneration at the wound site. Importantly, conductivity in skin tissue is reported to be essential for modulating myriad biological processes especially vascular and nerve regeneration. Herein, an extracellular matrix (ECM)-based conductive dressing is synthesized from an interpenetrating polymer network hydrogel composed of gelatin methacryloyl, oxidized chondroitin sulfate (OCS), and OCS-polypyrrole conductive nanoparticles that can promote diabetic wound repairing by enhancing local neurovascular regeneration. The conductive hydrogels combine the advantageous features of water-swollen hydrogels with conductive polymers (CPs) to provide tissue-matching electrical conductivity and mechanical properties for neurovascular regeneration. In vitro and in vivo studies show that the conductive hydrogel can promote neurovascular regeneration by increasing intracellular Ca2+ concentration, which subsequently promotes phosphorylation of proteins in the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) and mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) pathways. Furthermore, the conductive hydrogel stimulates full-thickness diabetic wound repair on day 14 by promoting local neurovascular regeneration and collagen deposition. These findings corroborate that the ECM-based conductive interpenetrating network hydrogel dressing significantly promotes wound repairing due to its neurovascular regeneration properties, suggesting that they are suitable candidates for diabetic wound repair.
Association of Genetic Variants With Outcomes in Patients With Nonischemic Dilated Cardiomyopathy
Authors: Luis Escobar-Lopez, Juan Pablo Ochoa, Jesús G. Mirelis, María Ángeles Espinosa, Marina Navarro, María Gallego-Delgado, Roberto Barriales-Villa, Ainhoa Robles-Mezcua, María Teresa Basurte-Elorz, Laura Gutiérrez García-Moreno, Vicente Climent, Juan Jiménez-Jaimez, María Victoria Mogollón-Jiménez, Javier Lopez, María Luisa Peña-Peña, Ana García-Álvarez, María Brion, Tomas Ripoll-Vera, Julián Palomino-Doza, Coloma Tirón, Uxua Idiazabal, Maria Noël Brögger, Soledad García-Hernández, María Alejandra Restrepo-Córdoba, Esther Gonzalez-Lopez, Irene Méndez, María Sabater, Eduardo Villacorta, José M. Larrañaga-Moreira, Ana Abecia, Ana Isabel Fernández, José M. García-Pinilla, José F. Rodríguez-Palomares, Juan Ramón Gimeno-Blanes, Antoni Bayes-Genis, Enrique Lara-Pezzi, Fernando Domínguez, Pablo Garcia-Pavia
Journal: Journal of the American College of Cardiology (2021)
P24.04 Concordance of Tissue and Cell-Free DNA-Based Next-Generation Sequencing in Patients With Lung Adenocarcinoma
Authors: M. Tran, G. Strohbehn, S. Rouhani, A. Shergill, P. Hoffman, J. Patel, J. Segal, E. Vokes, C. Bestvina
Journal: Journal of Thoracic Oncology (2021)
Comment on Paolisso et al. Impact of Admission Hyperglycemia on Heart Failure Events and Mortality in Patients With Takotsubo Syndrome at Long-term Follow-up: Data From HIGH-GLUCOTAKO Investigators. Diabetes Care 2021;44:2158–2161
Authors: John E. Madias
Journal: Diabetes Care (2021)

I read with interest the contribution by Paolisso et al. (1) about the performance of admission hyperglycemia (AH) (blood glucose >140 mg/dL) as a predictor of long-term prognosis in 76 patients with takotsubo syndrome (TTS), 28 with and 48 without AH. Patients with AH showed lower left ventricular ejection fraction on admission and discharge and higher levels of B-type natriuretic peptide and inflammatory …
Poly(ADP-Ribose) Polymerase Inhibitors and Myeloid Neoplasm Risk—Clues to a Mechanistic Connection?
Authors: Christine Walsh, Ilana Cass
Journal: JAMA Oncology (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Cardiac Transplantation and Mechanical Circulatory Support in Amyloidosis
Authors: Ronald M. Witteles
Journal: JACC CardioOncology (2021)

• Cardiac transplantation for amyloidosis was once considered contraindicated owing to unacceptably high morbidity/mortality rates. • Increased therapeutic options for AL and ATTR amyloidosis and improved pre-transplantation screening practices have led to markedly improved transplant outcomes over the past 10-15 years. • Mechanical circulatory support options remain limited but can be considered in selected patients, particularly for those with larger ventricular cavities. • Transplant prioritization rules may need to be reconsidered for amyloidosis patients to adequately prioritize AL amyloidosis patients, who are at increased risk of pre-transplantation mortality.
Prevalence and risk factors of upper gastrointestinal cancers missed during endoscopy: a nationwide registry-based study
Authors: Wladyslaw Januszewicz, Klaudiusz Witczak, Paulina Wieszczy, Magda Socha, Maryla H. Turkot, Urszula Wojciechowska, Joanna Didkowska, Michal F. Kaminski, Jaroslaw Regula
Journal: Endoscopy (2021)

A significant proportion of upper gastrointestinal cancers (UGICs) remain undetected during esophagogastroduodenoscopy (EGD). We investigated the characteristics and risk factors of UGICs missed during endoscopy.In this nationwide registry-based study, we analyzed two large Polish datasets (National Health Fund and National Cancer Registry) to identify individuals who underwent EGD and were subsequently diagnosed with UGIC. Cancers diagnosed < 6 months after EGD were defined as "prevalent" and those within ≥ 6- < 36 months as "missed." We compared the characteristics of missed and prevalent cancers, and analyzed the risk factors for missed UGICs in a multivariable regression model.We included 4 105 399 patients (mean age 56.0 years [SD 17.4]; 57.5 % female) who underwent 5 877 674 EGDs in 2012-2018. Within this cohort, 33 241 UGICs were diagnosed, of which 1993 (6.0 %) were missed. Within esophageal neoplasms, adenocarcinomas were more frequently missed than squamous cell cancers (6.1 % vs. 4.2 %), with a relative risk of 1.4 (95 % confidence interval [CI] 1.1-1.8, P = 0.01). Most gastric cancers were adenocarcinomas, of which 5.7 % were classified as missed. Overall, a higher proportion of missed UGICs than prevalent cancers presented at an advanced stage (42.2 % vs. 36.2 %, P < 0.001). Risk factors for missed UGICs included initial EGD performed within primary (vs. secondary) care (odds ratio [OR] 1.3, 95 %CI 1.2-1.5), female sex (OR 1.3, 95 %CI 1.2-1.4), and higher comorbidity (Charlson comorbidity index ≥ 5 vs. 0; OR 6.0, 95 %CI 4.7-7.5).Among UGICs, esophageal adenocarcinomas were missed most frequently. Missed cancers occur more frequently within the primary care sector and are found more often in women and individuals with multiple comorbidities.
Effectiveness of the mRNA-1273 Vaccine during a SARS-CoV-2 Delta Outbreak in a Prison
Authors: Elizabeth T Chin, David Leidner, Yifan Zhang, Elizabeth Long, Lea Prince, Ying Li, Jason R Andrews, David M Studdert, Jeremy D Goldhaber-Fiebert, Joshua A Salomon
Journal: New England Journal of Medicine (2021)

Effectiveness of the mRNA-1273 Vaccine during a SARS-CoV-2 Delta Outbreak in a PrisonTo the Editor: The mRNA vaccines have been shown to be highly effective in preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and associated illness, 1,2 although recent reports suggest reduced effectiveness against infection with the B.1.617.2 (or delta) variant. 3,4We assessed the effectiveness of the mRNA-1273 (Moderna) vaccine among incarcerated men during a coronavirus disease 2019 (Covid-19) outbreak that was dominated by transmission of the delta variant.The Sierra Conservation Center (SCC), in Jamestown, California, is a low-to-medium security prison for men.No SARS-CoV-2 infections were detected among residents between April 23 and July 15, 2021.A substantial outbreak began on July 16, which resulted in 15% of the exposed population becoming infected by August 15, 2021 (Fig. S1 in the Supplementary Appendix, available with the full text of this letter at NEJM .org).The delta variant was identified in all 13 successfully sequenced positive samples that had been obtained from SCC residents from July 16 to July 21, 2021.The delta variant was also identified in all 6 successfully assayed positive samples obtained from SCC staff during this period.We tracked infections over a 30-day period (July 16 to August 15, 2021) among SCC residents who had close exposure during that time; close exposure was defined as residence in a housing unit in which at least one case had been detected.Our goal was to estimate vaccine effectiveness against SARS-CoV-2 infection (with infection confirmed by means of polymerasechain-reaction or antigen test) and symptomatic infection, defined as a case involving symptoms observed by prison health care staff or objective signs of fever (a temperature of ≥37.8°C) or hypoxemia (an oxygen saturation of <94%) within 3 days before to 10 days after the collection date of a sample that tested positive.The mRNA-1273 vaccine accounted for 75% of all vaccines administered to SCC residents as of July 16, 2021.Residents who were fully vaccinated with the mRNA-1273 vaccine (i.e., had received a second dose at least 14 days previously) were matched with unvaccinated controls with the use of propensity scores (details are provided in the Supplementary Appendix).Vaccine effectiveness was calculated as one minusThe New England Journal of Medicine Downloaded from nejm.org
P57.09 Common Oncogenic Driver Mutations and PD-L1 Expression in Non-Small Cell Lung Cancer of Smokers and Never Smokers
Authors: C.K. Liam, C.Y. Yew, Y.K. Pang, C.K. Wong, M.E. Poh, J.L. Tan, C.I. Soo, T.C. Loh, K.K. Chin, V. Munusamy, N.H. Ibrahim
Journal: Journal of Thoracic Oncology (2021)
Response to Comment on Paolisso et al. Impact of Admission Hyperglycemia on Heart Failure Events and Mortality in Patients With Takotsubo Syndrome at Long-term Follow-up: Data From HIGH-GLUCOTAKO Investigators. Diabetes Care 2021;44:2158–2161
Authors: Pasquale Paolisso, Luca Bergamaschi, Pietro Rambaldi, Gianluca Gatta, Alberto Foà, Francesco Angeli, Michele Fabrizio, Gianni Casella, Michelangela Barbieri, Nazzareno Galiè, Raffaele Marfella, Carmine Pizzi, Celestino Sardu
Journal: Diabetes Care (2021)

In a letter in this issue of Diabetes Care , Madias suggests that norepinephrine, as mediator of admission hyperglycemia (AH), is an index of increased underlying sympathetic overactivity and/or diabetes comorbidity in patients with takotsubo syndrome (TTS) (1). Indeed, the 28 patients with AH versus the 48 patients without AH had a higher prevalence of diabetes (39.3% vs. 14.6%) (1,2). Notably, AH was a predictor of long-term prognosis in TTS patients (2). Moreover, the patients with AH showed lower left ventricular ejection fraction on admission and discharge and higher B-type natriuretic peptide and inflammatory markers, with the glucose values correlating with serum norepinephrine levels …
Expression status of folate receptor α (FOLR1) and reduced folate carrier (RFC1) can predict clinical outcome in non-small cell lung cancers (NSCLC).
Authors: Shotaro Iwakiri, Makoto Sonobe, Ryo Miyahara, Shinjiro Nagai, Masatsugu Nakagawa, Eiji Ogawa, Nobuya Mino, Toshiki Hirata, Hiromi Wada
Journal: Cancer Research (2007)

2694  Purpose: The folate receptor α (FOLR1) and the reduced folate carrier 1 (RFC1) are well-characterized folate transporters. FOLR1 and RFC1 are highly expressed in the lung. Furthermore, FOLR1 is highly expressed in some solid epithelial tumors, such as mesothelioma and adenocarcinoma of the lung. It may be leading to the development of diagnostic agents and therapy target at FOLR1 or RFC1 overexpressing tumors, but no clinical study on RFC1 expression and only one clinical study on FOLR1 expression in non small cell lung cancer (NSCLC) has been reported, which showed by immunohistochemistry. The purpose of this study is to evaluate prognostic significance of FOLR1 expression and RFC1 expression in completely resected NSCLC.  Patients and methods : We quantitatively examined gene expression of the FOLR1 and RFC1 in surgical specimens resected from NSCLC patients. A total of 119 consecutive patients with NSCLC who underwent resection at our institute, from January 2003 to June 2004 were included in this study.  Results : In adenocarcinoma, the FOLR1 gene expression was down-regulated in smokers and male patients (P = 0.006 and P  Conclusion : The higher levels of FOLR1 appear to be associated with better prognosis of the patients in lung adenocarcinoma.
Exhausted local lactate accumulation via injectable nanozyme-functionalized hydrogel microsphere for inflammation relief and tissue regeneration
Authors: Jieliang Shen, Ao Chen, Zhengwei Cai, Zhijie Chen, Ruichao Cao, Zongchao Liu, Yuling Li, Jie Hao
Journal: Bioactive Materials (2021)

Local lactate accumulation greatly hinders tissue repair and regeneration under ischemic condition. Herein, an injectable microsphere (MS@MCL) for local lactate exhaustion was constructed by grafting manganese dioxide (MnO2) -lactate oxidase (LOX) composite nanozyme on microfluidic hyaluronic acid methacrylate (HAMA) microspheres via chemical bonds, achieving a long-term oxygen-promoted lactate exhaustion effect and a long half-life in vivo. The uniform and porous microspheres synthesized by microfluidic technology is beneficial to in situ injection therapy and improving encapsulation efficiency. Furthermore, chemical grafting into HAMA microspheres through amide reactions promoted local enzymatic concentration and activity enhancement. It was showed that the MS@MCL eliminated oxidative and inflammatory stress and promoted extracellular matrix metabolism and cell survival when co-cultured with nucleus pulposus cells (NPCs) in vitro. In the rat degenerative intervertebral disc model caused by lactate injection, MS@MCL showed a long-term therapeutic effect in reducing intervertebral height narrowing and preventing extracellular matrix (ECM) degradation as well as inflammatory damage in vivo. Altogether, this study confirms that this nanozyme-functionalized injectable MS@MCL effectively improves the regenerative and reparative effect in ischemic tissues by disposing of enriched lactate in local microenvironment.
28450 Longitudinal brush pigmentation: A dermoscopic feature on hyponychium in 3 cases of melanocytic nevi in children
Authors: Jongeun Lee, Young Hwan Choi, Jaihee Bae, Dong Min Shin, Donghwi Jang Dokyoung, Yoon Jongeun Lee, Se Jin Oh, Hyun Je Kim, Dong-Youn Lee
Journal: Journal of the American Academy of Dermatology (2021)
Efficacy and Safety of Adalimumab and Infliximab for Noninfectious Uveitis
Authors: Felicia Tai, Parsa Mehraban Far, Petros Pechlivanoglou, Lauren C. Ramsay, Jorge R. Georgakopoulos, Beate Sander, Larissa A. Derzko-Dzulynsky, Tina Felfeli
Journal: Ophthalmology (2021)
MA13.01 Camrelizumab Plus Apatinib in Treatment-Naive Patients With Advanced Non-Squamous NSCLC: A Multicenter, Open-Label, Single-Arm, Phase 2 Trial
Authors: S.(. Ren, J. He, Y. Fang, G. Chen, Z. Ma, J. Chen, R. Guo, X. Lin, Y. Yao, G. Wu, Q. Wang, C. Zhou
Journal: Journal of Thoracic Oncology (2021)
The role of diffusion tensor imaging metrics in machine learning-based characterisation of paediatric brain tumors and their practicality for multicentre clinical assessment
Authors: Heather Rose, Huijun Li, Christopher D Bennett, Jan Novak, Yu Sun, Lesley MacPherson, Shivaram Avula, Theodoros Arvanitis, Christopher Clark, Simon Bailey, Dipayan Mitra, Dorothee Auer, Richard Grundy, Andrew Peet
Journal: Neuro-Oncology (2021)

Abstract Aims Magnetic resonance imaging (MRI) is a valuable tool for non-invasive diagnosis of paediatric brain tumours. The rarity of the disease dictates multi-centre studies and imaging biomarkers that are robust to protocol variability. We investigated diffusion tensor MRI (DT-MRI), combined with machine learning, as an aid to diagnosis and evaluated the robustness of the imaging metrics. Method A multi-centre cohort of 52 clinical DT-MRI scans (20 medulloblastomas (MB), 21 pilocytic astrocytomas (PA), 11 ependymomas (EP)) were analysed retrospectively. Histograms for regions of solid tumour for fractional anisotropy (FA), mean diffusivity (MD), pure anisotropic diffusion (q) and pure isotropic diffusion (p) were compared to assess diagnostic capability. Linear discriminate analysis (LDA) was used for classification and validated using leave-one-out-cross-validation (LOOCV). Results Histogram medians for FA, MD, q and p were all different between tumor groups (P&amp;lt;.0001, Kruskal Wallis test). Median MD, p and q values were highest in PA, then EP and lowest in MB (P&amp;lt;.0001, Pairwise Wilcox test). FA median was higher for EP than PA (P=.004) with no significant difference between EP and MB (P=.591). ROC analysis showed that median MD, q and p perform best as a diagnostic marker (AUC= 0.92 to 0.99). LOOCV showed an overall accuracy of the LDA classification, ranging between 67% - 87%. FA values were highly dependent on protocol parameters, whereas pure anisotropic diffusion, q, was not. Conclusion DT-MRI metrics from multi-centre acquisitions can classify paediatric brain tumours. FA is the least robust metric to protocol variability and q provides the most robust quantification of anisotropic behaviour.
A global call for talaromycosis to be recognised as a neglected tropical disease
Authors: Shanti Narayanasamy, Vu Quoc Dat, Nguyen Tat Thanh, Vo Trieu Ly, Jasper Fuk-Woo Chan, Kwok-Yung Yuen, Chuanyi Ning, Hao Liang, Linghua Li, Anuradha Chowdhary, Sirida Youngchim, Khuanchai Supparatpinyo, Ne Myo Aung, Josh Hanson, Alex Andrianopoulos, John Dougherty, Nelesh P Govender, David W Denning, Tom Chiller, Guy Thwaites, H Rogier van Doorn, John Perfect, Thuy Le
Journal: The Lancet Global Health (2021)

Talaromycosis (penicilliosis) is an invasive mycosis that is endemic in tropical and subtropical Asia. Talaromycosis primarily affects individuals with advanced HIV disease and other immunosuppressive conditions, and the disease disproportionally affects people in low-income and middle-income countries, particularly agricultural workers in rural areas during their most economically productive years. Approximately 17 300 talaromycosis cases and 4900 associated deaths occur annually. Talaromycosis is highly associated with the tropical monsoon season, when flooding and cyclones can exacerbate the poverty-inducing potential of the disease. Talaromycosis can present as localised or disseminated disease, the latter causing cutaneous lesions that are disfiguring and stigmatising. Despite up to a third of diagnosed cases resulting in death, talaromycosis has received little attention and investment from regional and global funders, policy makers, researchers, and industry. Diagnostic and treatment modalities remain extremely insufficient, however control of talaromycosis is feasible with known public health strategies. This Viewpoint is a global call for talaromycosis to be recognised as a neglected tropical disease to alleviate its impact on susceptible populations.
Prevalence and Prognostic Implications of Diabetes With Cardiomyopathy in Community-Dwelling Adults
Authors: Matthew W. Segar, Muhammad Shahzeb Khan, Kershaw V. Patel, Javed Butler, W.H. Wilson Tang, Muthiah Vaduganathan, Carolyn S.P. Lam, Subodh Verma, Darren K. McGuire, Ambarish Pandey
Journal: Journal of the American College of Cardiology (2021)

Diabetes is associated with abnormalities in cardiac remodeling and high risk of heart failure (HF). The purpose of this study was to evaluate the prevalence and prognostic implications of diabetes with cardiomyopathy (DbCM) among community-dwelling individuals. Adults without prevalent cardiovascular disease or HF were pooled from 3 cohort studies (ARIC [Atherosclerosis Risk In Communities], CHS [Cardiovascular Health Study], CRIC [Chronic Renal Insufficiency Cohort]). Among participants with diabetes, DbCM was defined using different definitions: 1) least restrictive: ≥1 echocardiographic abnormality (left atrial enlargement, left ventricle hypertrophy, diastolic dysfunction); 2) intermediate restrictive: ≥2 echocardiographic abnormalities; and 3) most restrictive: elevated N-terminal pro–B-type natriuretic peptide levels (>125 in normal/overweight or >100 pg/mL in obese) plus ≥2 echocardiographic abnormalities. Adjusted Fine-Gray models were used to evaluate the risk of HF. Among individuals with diabetes (2,900 of 10,208 included), the prevalence of DbCM ranged from 67.0% to 11.7% in the least and most restrictive criteria, respectively. Higher fasting glucose, body mass index, and age as well as worse kidney function were associated with higher risk of DbCM. The 5-year incidence of HF among participants with DbCM ranged from 8.4%-12.8% in the least and most restrictive definitions, respectively. Compared with euglycemia, DbCM was significantly associated with higher risk of incident HF with the highest risk observed for the most restrictive definition of DbCM (HR: 2.55 [95% CI: 1.69-3.86]; least restrictive criteria HR: 1.99 [95% CI: 1.50-2.65]). A similar pattern of results was observed across cohort studies, across sex and race subgroups, and among participants without hypertension or obesity. Regardless of the criteria used to define cardiomyopathy, DbCM identifies a high-risk subgroup for developing HF.
P70.02 Clinicopathological and Genetic Ancestry Impact of TP53 Mutations in Brazilian Lung Adenocarcinoma Patients
Authors: R. De Oliveira Cavagna, F. Escremim De Paula, G. Noriz Berardinelli, D. Sant'Anna, I. Santana, V. Duval Da Silva, E.C. Albino Da Silva, J.E. Miziara, J. Mourão Dias, P. De Marchi, L. Ferro Leal, R.M. Vieira Reis
Journal: Journal of Thoracic Oncology (2021)
P57.07 The Scottish Immunotherapy Prognostic Score (SIPS) Predicts Response to First-Line Pembrolizumab for Metastatic Non-Small Cell Lung Cancer
Authors: M. Stares, T. Ding, C. Stratton, F. Thomson, M. Mackean, K. Cumming, C. Barrie, K. Maclennan, S. Campbell, T. Evans, A. Tufail, I. Phillips
Journal: Journal of Thoracic Oncology (2021)