tbuckley/cabot-search huggingface dataset:
Universal definition and classification of heart failure: a report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure
Authors: Biykem Bozkurt, Andrew J.S. Coats, Hiroyuki Tsutsui, Ca Magdy Abdelhamid, Stamatis Adamopoulos, Nancy Albert, Stefan D. Anker, John Atherton, Michael Böhm, Javed Butler, Mark H. Drazner, G. Michael Felker, Gerasimos Filippatos, Mona Fiuzat, Gregg C. Fonarow, Juan‐Esteban Gomez‐Mesa, Paul Heidenreich, Teruhiko Imamura, Ewa A. Jankowska, James Januzzi, Prateeti Khazanie, Koichiro Kinugawa, Carolyn S.P. Lam, Yuya Matsue, Marco Metra, Tomohito Ohtani, Massimo Francesco Piepoli, Piotr Ponikowski, Giuseppe M.C. Rosano, Yasushi Sakata, Petar Seferović, Randall C. Starling, John R. Teerlink, Orly Vardeny, Kazuhiro Yamamoto, Clyde Yancy, Jian Zhang, Shelley Zieroth
Journal: European Journal of Heart Failure (2021)
Abstract 18639: Implantable Cardioverter-defibrillator Use is Associated With Improved Survival on the Waitlist for Heart Transplantation: A UNOS/ OPTN Registry Analysis of 36,397 Patients
Authors: Kairav Vakil, Rebecca Cogswell, Sue Duval, Wayne Levy, Peter Eckman, Inder Anand, Todd Dardas, Selcuk Adabag
Journal: Circulation (2015)

Background: Current guidelines do not support routine use of implantable cardioverter-defibrillators (ICDs) in patients (pts) with end-stage heart failure (HF), unless these pts are awaiting advanced HF therapies such as left ventricular assist devices (LVADs) or a heart transplantation (HT). Whether ICDs improve survival in end-stage HF pts awaiting HT has not been previously examined in a large, multicenter cohort. Hypothesis: Presence of ICDs at time of listing for HT is associated with lower waitlist mortality. Methods: The United Network for Organ Sharing registry was used to identify adults (≥18 years) listed for HT between January 4, 1999 &amp; September 30, 2014. Pts with congenital heart disease, total artificial heart, restrictive cardiomyopathy, prior HT, or missing covariates were excluded. Cox regression analysis was used to assess the impact of an ICD at the time of listing on waitlist mortality. Results: The analysis included 36,397 pts (mean age 53±12; 77% males) listed for HT. The prevalence of ICDs at listing has steadily increased over time before reaching a plateau in 2006 (27% in 1999, and range 76-82% between 2006-2014). In the unadjusted model, ICD use was associated with a 36% reduction in waitlist mortality (HR 0.64, 95% CI 0.60-0.68, p&lt;0.001). After adjustment for covariates such as age, sex, race, creatinine, ischemic cardiomyopathy, and listing status, this association was nearly unchanged (HR 0.67, 95% CI 0.62-0.72, p&lt;0.001). Test for interaction by listing era (pre- and post-2006) was non-significant (p=0.28). In the final adjusted model, that included listing era and LVAD status in addition to the above listed covariates, ICD use continued to remain associated with a mortality benefit on the waitlist for HT (HR 0.84, 95% CI 0.78-0.91, p&lt;0.001). Conclusion: ICDs are increasingly prevalent in pts listed for HT; however many pts are still listed for HT without these devices. The presence of an ICD at the time of listing is associated with lower mortality on the waitlist. Although the magnitude of ICD efficacy diminishes slightly, its benefit continues to remain significant even after adjustment for listing era and LVAD use. Further analyses are required to identify specific sub-groups of pts where ICD use is most beneficial and appropriate.
Endoscopic submucosal dissection for polyps in the anal transitional zone after ileoanal anastomosis in a patient with familial adenomatous polyposis
Authors: Catarina O’Neill, Pedro Barreiro, Rui Mendo, Catarina Félix, Iala Costa, Cristina Chagas
Journal: Endoscopy (2021)

A 48-year-old man with a history of familial adenomatous polyposis (FAP) underwent prophylactic restorative proctocolectomy and ileal-pouch anal anastomosis 16 years ago and was subsequently lost to follow-up. He re-presented with rectal bleeding and endoscopy revealed multiple coalescent polypoid lesions (T0-Is + IIa), circumferentially occupying the anal transitional zone ([Fig. 1 a]) and the area of the surgical anastomosis ([Fig. 1 b]). Biopsy specimens showed a tubulovillous adenoma with low grade dysplasia and focal high grade dysplasia. The patient was referred for treatment by endoscopic submucosal dissection (ESD).
Antibiotic prophylaxis and the gastrointestinal resistome in paediatric patients with acute lymphoblastic leukaemia: a cohort study with metagenomic sequencing analysis
Authors: Elisa B Margolis, Hana Hakim, Ronald H Dallas, Kim J Allison, Jose Ferrolino, Yilun Sun, Ching-Hon Pui, Jiangwei Yao, Ti-Cheng Chang, Randall T Hayden, Sima Jeha, Elaine I Tuomanen, Li Tang, Jason W Rosch, Joshua Wolf
Journal: The Lancet Microbe (2021)

Although antibiotic prophylaxis with levofloxacin can reduce the risk of serious infection in immunocompromised patients, the potential contribution of prophylaxis to antibiotic resistance is a major drawback. We aimed to identify the effects of levofloxacin prophylaxis, given to paediatric patients with acute lymphoblastic leukaemia to prevent infections during induction chemotherapy, on antibiotic resistance in gastrointestinal microbiota after completion of induction and consolidation therapy.
Incidentally Diagnosed Esophago-Pulmonary Fistula on 18F-FDG PET/CT in a Case of Carcinoma Esophagus
Authors: Mudalsha Ravina, Himanshu Bansal, Tinu Thadiyananickal Lukose, Ajit Kumar Mishra, Amal Moideen
Journal: Clinical Nuclear Medicine (2021)

Abstract Esophago-pulmonary fistulas are very less reported in literature. 18 F-FDG PET/CT scan is routinely used for evaluation of patients of carcinoma esophagus. We present a case of carcinoma esophagus with acquired esophago-pulmonary fistula diagnosed on 18 F-FDG PET/CT scan.
Abstract 12831: Impact of Fondaparinux vs Low Molecular Weight Heparin on In-hospital Bleeding and One-year Death in Non-ST-segment Elevation Myocardial Infarction: Should we Apply the ESC Guidelines? Real-world Data from FAST-MI 2010
Authors: Etienne Puymirat, Pierre-Vladimir Ennezat, Yves Cottin, Pierre Coste, Francois Schiele, Jean-Philippe Collet, Eric Bonnefoy-Cudraz, Gerald Roul, Pascal Richard, Tabassome Simon, Nicolas Danchin
Journal: Circulation (2013)

Background: ESC guidelines recommend fondaparinux as the best anticoagulant in patients with non-ST-elevation Acute Myocardial Infarction (NSTEMI), whereas ACC/AHA guidelines do not favor fondapari...
Abstract 19252: Onset Scenarios of Paroxysmal Atrial Fibrillation in Patients with Ischemic Stroke
Authors: Hendrik Bonnemeier, Franziska Kurtz, Sarah Sandrock, Thomas Demming
Journal: Circulation (2012)

The characterization of onset scenarios of paroxysmal atrial fibrillation (pAF) has recently gained prominence to determine various underlying arrhythmogenic trigger mechanisms. It is hypothesized that there might be specific onset scenarios of pAF in patients with ischemic stroke, however, onset scenarios of pAF have not yet been systematically analysed in a broad patient population without pacemaker indication and especially those patients after ischemic stroke. Methods and Results: From a total of 20.546 consecutive ambulatory 24-hour-Holter-ECG-recordings, 668 episodes of pAF (lasting &gt; 1 minute) were identified in 343 patients without previous stroke (155 females; 71±10years) and 35 pAF episodes in 20 patients after ischemic stroke (8 females; 67±15 years). The dominant portion of episodes of pAF was preceded by atrial ectopy [single atrial premature beats (APB), blocked APB, multiple APB, short atrial runs, short-long-short sequences] or heart rate alterations [bradycardia, tachycardia, sudden rate drop, ventricular premature beats (VPB)]. Almost one third of all pAF episodes were not preceded by either ectopy or heart rate alterations (i.e. sudden-onset pAF). There were no significant differences between patients with or without stroke regarding the distribution of pAF-onset patterns. Mean RR-interval during sinus-rhythm tended to be higher in patients after ischemic stroke (866±184ms vs 845±190ms; p=0.1) Conclusion: There are no significant differences regarding specific onset-scenarios of pAF patients after ischemic stroke and in patients without stroke. Interestingly, patients with stroke tended to have lower heart rates during sinus rhythm.
Regulating PFAS as a Chemical Class under the California Safer Consumer Products Program
Authors: Simona Andreea Bălan, Vivek Chander Mathrani, Dennis Fengmao Guo, André Maurice Algazi
Journal: Environmental Health Perspectives (2021)

BACKGROUND: Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a group of manmade chemicals containing at least one fully fluorinated carbon atom.The widespread use, large number, and diverse chemical structures of PFAS pose challenges to any sufficiently protective regulation, emissions reduction, and remediation at contaminated sites.Regulating only a subset of PFAS has led to their replacement with other members of the class with similar hazards, that is, regrettable substitutions.Regulations that focus solely on perfluoroalkyl acids (PFAAs) are ineffective, given that nearly all other PFAS can generate PFAAs in the environment.OBJECTIVES: In this commentary, we present the rationale adopted by the State of California's Department of Toxic Substances Control (DTSC) for regulating PFAS as a class in certain consumer products.DISCUSSION: We at the California DTSC propose regulating certain consumer products if they contain any member of the class of PFAS because: a) all PFAS, or their degradation, reaction, or metabolism products, display at least one common hazard trait according to the California Code of Regulations, namely environmental persistence; and b) certain key PFAS that are the degradation, reaction or metabolism products, or impurities of nearly all other PFAS display additional hazard traits, including toxicity; are widespread in the environment, humans, and biota; and will continue to cause adverse impacts for as long as any PFAS continue to be used.Regulating PFAS as a class is thus logical, necessary, and forward-thinking.This technical position may be helpful to other regulatory agencies in comprehensively addressing this large class of chemicals with common hazard traits.
Abstract 20710: MSCs Preserve RV Function in a PA Banding Swine Model by GDF15-miR132 Enriched Exosomes
Authors: Rachana Mishra, Greg Bittle, Sudhish Sharma, Progyaparamita Saha, Sunjay Kaushal
Journal: Circulation (2017)

Background: Hypoplastic left heart syndrome (HLHS) patients have the highest morbidity and mortality rates of all congenital heart disease (CHD) patients in spite of significant medical and surgica...
Effectiveness and cost-effectiveness of reactive, targeted indoor residual spraying for malaria control in low-transmission settings: a cluster-randomised, non-inferiority trial in South Africa
Authors: David Bath, Jackie Cook, John Govere, Phillemon Mathebula, Natashia Morris, Khumbulani Hlongwana, Jaishree Raman, Ishen Seocharan, Alpheus Zitha, Matimba Zitha, Aaron Mabuza, Frans Mbokazi, Elliot Machaba, Erik Mabunda, Eunice Jamesboy, Joseph Biggs, Chris Drakeley, Devanand Moonasar, Rajendra Maharaj, Maureen Coetzee, Catherine Pitt, Immo Kleinschmidt
Journal: The Lancet (2021)

BackgroundIncreasing insecticide costs and constrained malaria budgets could make universal vector control strategies, such as indoor residual spraying (IRS), unsustainable in low-transmission settings. We investigated the effectiveness and cost-effectiveness of a reactive, targeted IRS strategy.MethodsThis cluster-randomised, open-label, non-inferiority trial compared reactive, targeted IRS with standard IRS practice in northeastern South Africa over two malaria seasons (2015–17). In standard IRS clusters, programme managers conducted annual mass spray campaigns prioritising areas using historical data, expert opinion, and other factors. In targeted IRS clusters, only houses of index cases (identified through passive surveillance) and their immediate neighbours were sprayed. The non-inferiority margin was 1 case per 1000 person-years. Health service costs of real-world implementation were modelled from primary and secondary data. Incremental costs per disability-adjusted life-year (DALY) were estimated and deterministic and probabilistic sensitivity analyses conducted. This study is registered with ClinicalTrials.gov, NCT02556242.FindingsMalaria incidence was 0·95 per 1000 person-years (95% CI 0·58 to 1·32) in the standard IRS group and 1·05 per 1000 person-years (0·72 to 1·38) in the targeted IRS group, corresponding to a rate difference of 0·10 per 1000 person-years (–0·38 to 0·59), demonstrating non-inferiority for targeted IRS (p<0·0001). Per additional DALY incurred, targeted IRS saved US$7845 (2902 to 64 907), giving a 94–98% probability that switching to targeted IRS would be cost-effective relative to plausible cost-effectiveness thresholds for South Africa ($2637 to $3557 per DALY averted). Depending on the threshold used, targeted IRS would remain cost-effective at incidences of less than 2·0–2·7 per 1000 person-years. Findings were robust to plausible variation in other parameters.InterpretationTargeted IRS was non-inferior, safe, less costly, and cost-effective compared with standard IRS in this very-low-transmission setting. Saved resources could be reallocated to other malaria control and elimination activities.FundingJoint Global Health Trials.
Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation
Authors: Daniel F. Dwyer, Jose Ordovas-Montanes, Samuel J. Allon, Kathleen M. Buchheit, Marko Vukovic, Tahereh Derakhshan, Chunli Feng, Juying Lai, Travis K. Hughes, Sarah K. Nyquist, Matthew P. Giannetti, Bonnie Berger, Neil Bhattacharyya, Rachel E. Roditi, Howard R. Katz, Martijn C. Nawijn, Marijn Berg, Maarten van den Berge, Tanya M. Laidlaw, Alex K. Shalek, Nora A. Barrett, Joshua A. Boyce
Journal: Science Immunology (2021)

Mast cells in type 2 airway inflammation exhibit heterogeneous inflammation-associated phenotypes and proliferate in situ.
Correspondence on ‘Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm syndrome: results of the CHIC study’
Authors: Pierre Charles
Journal: Annals of the Rheumatic Diseases (2021)

I was surprised when I read your web page promoting the study ‘Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm syndrome: results of the CHIC study’.1 The methodology of this study (comparison of a treatment with a historical control) is known to lead to major biases. The results were positive, consistent with …
Proteosome inhibitor Bortezomib (Velcade®) induces apoptosis via degradation of SKP2 in ovarian cancer
Authors: Maqbool Ahmed, Azhar Hussain, Prashant Bavi, Mona Ibrahim, Rafat El-Sayed, Adnan Munkarah, Shahab Uddin, Khawla Al-Kuraya
Journal: Cancer Research (2008)

1182  Ubiquitin-depends proteolysis of cyclins plays a critical role in cell cycle progression and tumorigenesis in varieties of cancer. SKP2, an F-box protein targets cell cycle regulators including cycle-dependent kinase inhibitor p27kip1 via ubiquitin-mediated degradation. SKP2 is frequently overexpressed in variety of cancers. We investigated the role of SKP2 and its Ubiquitin Proteasome pathway in epithelial ovarian cancer using a panel of cell lines, and Nude mouse model. Treatment of epithelial ovarian cancer cell lines with Bortezomib, an inhibitor of proteasomal pathway causes downregulation of SKP2 and accumulation of p27kip1 leading to apoptosis. Bortezomib induces activation of caspase-8 and cleavage of Bid subsequently leading to loss of mitochondrial membrane potential and release of cytochrome c into cytosol, resulting in activation of caspase-3 and cleavage of PARP. In addition, treatment of epithelial ovarian cancer cells with Bortezomib downregulated the expression of XIAP, and survivin. The expression of SKP2 is suppressed by targeted knock-down with small interfering RNA. The ablation of SKP2 activity causes a dramatic down-regulation of Skp2 protein leading to upregulation of p27Kip1. In addition, we demonstrate that pretreatment of epithelial ovarian cancer cells with z-VAD-fmk, a universal inhibitor of caspases abrogates caspase and PARP activation and prevents cell death induced by Bortezomib. Finally, treatment of ovarian cancer cell line Xenograft with Bortezomib resulted in growth inhibition of tumors in Nude mice via down regulation of SKP2 and accumulation of p27kip1. Altogether, these results suggest that SKP2 and ubiquitin-proteasome pathway may be a potential target for therapeutic intervention for treatment of epithelial ovarian cancer.
Ovariectomy induces bone loss via microbial-dependent trafficking of intestinal TNF+ T cells and Th17 cells
Authors: Mingcan Yu, Subhashis Pal, Cameron W. Paterson, Jau-Yi Li, Abdul Malik Tyagi, Jonathan Adams, Craig M. Coopersmith, M. Neale Weitzmann, Roberto Pacifici
Journal: Journal of Clinical Investigation (2021)

Estrogen deficiency causes a gut microbiome–dependent expansion of BM Th17 cells and TNF-α–producing T cells. The resulting increased BM levels of IL-17a (IL-17) and TNF stimulate RANKL expression and activity, causing bone loss. However, the origin of BM Th17 cells and TNF+ T cells is unknown. Here, we show that ovariectomy (ovx) expanded intestinal Th17 cells and TNF+ T cells, increased their S1P receptor 1–mediated (S1PR1-mediated) egress from the intestine, and enhanced their subsequent influx into the BM through CXCR3- and CCL20-mediated mechanisms. Demonstrating the functional relevance of T cell trafficking, blockade of Th17 cell and TNF+ T cell egress from the gut or their influx into the BM prevented ovx-induced bone loss. Therefore, intestinal T cells are a proximal target of sex steroid deficiency relevant for bone loss. Blockade of intestinal T cell migration may represent a therapeutic strategy for the treatment of postmenopausal bone loss.
Response to systemic therapies in granulomatous cheilitis: Retrospective multicenter series of 61 patients
Authors: Frédéric Jaouen, Marie-Hélène Tessier, Loic Vaillant, Selma Azib-Meftah, Laurent Misery, Nathalie Bénéton, Emmanuel Delaporte, Amina Kaddour, Saskia Ingen-Housz-Oro, Stéphane Nahon, Marie Masson-Regnault, Vincent Sibaud, Jean-Christophe Fricain, Didier Bessis, Celine Girard, Mahtab Samimi
Journal: Journal of the American Academy of Dermatology (2021)
Reply to Claudia Signorini and Massimo Maffezzini’s Letter to the Editor re: Maria S. Lindgren, Peter Bue, Nessn Azawi, et al. The DaBlaCa-13 Study: Short-term, Intensive Chemoresection Versus Standard Adjuvant Intravesical Instillations in Non–muscle-invasive Bladder Cancer—A Randomized Controlled Trial. Eur Urol 2020;78:856–62
Authors: Maria S. Lindgren, Jørgen B. Jensen
Journal: European Urology (2021)
Abstract PS14-28: Core−shell structured gold nanorods@iron-based metal-organic framework for magnetic resonance imaging guided photothermal therapy in triple-negative breast cancer
Authors: Jingchao He, Haijun Zhang
Journal: Cancer Research (2021)

Abstract Background/Objective: As the most aggressive subtype of breast cancer, triple-negative breast cancer (TNBC) with high mortality lacks effective treatment options and results in poor prognosis. Photothermal therapy (PTT) has emerged as a potential anticancer strategy. Until now, the construction of multifunctional photothermal agents is vital importance for effective PTT generally. In this work, the novel core-shell gold nanorods (GNs)@iron-based metal-organic framework (Fe-MOF) was firstly successfully fabricated for magnetic resonance imaging (MRI) guided PTT in TNBC. The inner GNs have excellent photothermal properties and the outer Fe-MOF shell endow the nanocomposite with superior T2 MRI property.Methods: The GNs @ Fe-MOF was firstly prepared by a layer-by-layer technique. Prepared nanocomposite was characterized by measuring measuring measuring transmission electron microscope (TEM), UV-Vis-NIR absorption spectra, powder X-radiffraction (XRD) patterns. MR imaging of nanocomposite was assessed in vitro and in vivo. The biocompatibility and photothermal cytotoxicity of the nanocomposite was assessed by a CCK-8 assay. The photothermal effect of nanocomposite in vivo was evaluated by monitoring tumor growth. The tumor tissues were analyzed by Hema-toxylin and eosin (H&amp;E) to further analyze photothermal effect. The toxicity of the materials in major organs was also investigated by H&amp;E.Result: The core-shell GNs @ Fe-MOF was successfully prepared and displayed excellent dispersion. The nanocomposite possessed good biocompatibility and effectively killed tumor cells under laser irradiation. Meanwhile, the nanocomposite showed clear signal contrast in T2-weighted images in vitro and in vivo. Moreover, the nanocomposite significantly inhibited tumor growth under laser irradiation in vivo. H&amp;E showed that the nanocomposite caused serious damage to tumor tissue under laser irradiation.Conclusion: The current work developed a novel multifunctional core-shell GNs @ Fe-MOF with good biocompatibility for MRI guided PTT in TNBC.Keywords : Magnetic resonance imaging, Photothermal therapy,gold nanorods@iron-based metal-organic Framework Citation Format: Jingchao He, Haijun Zhang. Core−shell structured gold nanorods@iron-based metal-organic framework for magnetic resonance imaging guided photothermal therapy in triple-negative breast cancer [abstract]. In: Proceedings of the 2020 San Antonio Breast Cancer Virtual Symposium; 2020 Dec 8-11; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2021;81(4 Suppl):Abstract nr PS14-28.