The Metabolic Syndrome as a Predictor of Nonalcoholic Fatty Liver Disease
Authors: Yujiro Kida, Tetsuji Sato
Journal: Annals of Internal Medicine (2006)

Letters7 March 2006The Metabolic Syndrome as a Predictor of Nonalcoholic Fatty Liver DiseaseYujiro Kida, MD, PhD and Tetsuji Sato, DMD, PhDYujiro Kida, MD, PhDFrom Tsurumi University School of Dental Medicine and Tokyo Medical and Dental University, Yokohama 230-8501, Japan.Search for more papers by this author and Tetsuji Sato, DMD, PhDFrom Tsurumi University School of Dental Medicine and Tokyo Medical and Dental University, Yokohama 230-8501, Japan.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-144-5-200603070-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Hamaguchi and colleagues (1) reported that the metabolic syndrome is a strong predictor of NAFLD; however, only a small portion of patients with NAFLD have features of nonalcoholic steatohepatitis (NASH). The authors referred to the roles of adipocytokines, such as leptin and adiponectin; however, serum leptin levels in patients with NASH were not statistically different from those in their matched controls (2). In addition, the investigators observed no correlation between serum leptin levels and hepatic histologic findings (2). In comparison, multivariate analysis revealed that patients with NASH had serum adiponectin levels that were lower than those in ...References1. Hamaguchi M, Kojima T, Takeda N, Nakagawa T, Taniguchi H, Fujii K, et al. The metabolic syndrome as a predictor of nonalcoholic fatty liver disease. Ann Intern Med. 2005;143:722-8. [PMID: 16287793] LinkGoogle Scholar2. Chalasani N, Crabb DW, Cummings OW, Kwo PY, Asghar A, Pandya PK, et al. Does leptin play a role in the pathogenesis of human nonalcoholic steatohepatitis? Am J Gastroenterol. 2003;98:2771-6. [PMID: 14687831] CrossrefMedlineGoogle Scholar3. Hui JM, Hodge A, Farrell GC, Kench JG, Kriketos A, George J. Beyond insulin resistance in NASH: TNF-alpha or adiponectin? Hepatology. 2004;40:46-54. [PMID: 15239085] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Tsurumi University School of Dental Medicine and Tokyo Medical and Dental University, Yokohama 230-8501, Japan.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Metabolic Syndrome as a Predictor of Nonalcoholic Fatty Liver Disease Masahide Hamaguchi , Takao Kojima , Noriyuki Takeda , Takayuki Nakagawa , Hiroya Taniguchi , Kota Fujii , Tatsushi Omatsu , Tomoaki Nakajima , Hiroshi Sarui , Makoto Shimazaki , Takahiro Kato , Junichi Okuda , and Kazunori Ida The Metabolic Syndrome as a Predictor of Nonalcoholic Fatty Liver Disease Masahide Hamaguchi , Noriyuki Takeda , and Takao Kojima The Metabolic Syndrome as a Predictor of Nonalcoholic Fatty Liver Disease Norberto C. Chavez-Tapia , Nahum Mendez-Sanchez , and Misael Uribe Metrics Cited ByNonalcoholic fatty liver disease: An overview of current insights in pathogenesis, diagnosis and treatmentDefinition of the Metabolic Syndrome: What's New and What Predicts Risk? 7 March 2006Volume 144, Issue 5Page: 379-380KeywordsAdipokinesAdiponectinConflicts of interestInsulin resistanceLeptinMetabolic syndromeMultivariate analysisNon-alcoholic fatty liver diseaseNonalcoholic steatohepatitisSteatosis ePublished: 7 March 2006 Issue Published: 7 March 2006 CopyrightCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...