tbuckley/cabot-search huggingface dataset:
Public Health and Aging: Retention of Natural Teeth Among Older Adults—United States, 2002
Journal: JAMA (2004)

During the past several decades, the percentage of older adults who have retained their natural teeth has increased steadily. This trend is expected to continue, resulting in improved oral function and quality of life. To estimate the prevalences of tooth retention and total tooth loss in 2002 among adults aged >/=65 years, CDC analyzed data from the Behavioral Risk Factor Surveillance System (BRFSS) survey. This report summarizes the results of that analysis, which indicated that in 26 (52%) states, more than half of older adults reported having most (i.e., losing five or fewer) of their natural teeth. However, rates varied substantially among states and by selected characteristics. With tooth retention, older adults remain at risk for dental caries (i.e., tooth decay) and periodontal disease. To help adults maintain healthy teeth for life, community-based strategies should promote healthy behaviors, optimal use of fluoride, timely examinations and clinical services, and increased research into preventing oral diseases and promoting oral health among adults.
The ups and downs of disease rates and sex
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Artificial Cardiac Pacemakers
Authors: Bernard Lown, Bernard D. Kosowsky
Journal: New England Journal of Medicine (1970)

MYTH and folklore frequently anticipate future developments, for they embody a kernel of objective reality. The medical uses of electricity over the ages attest to this maxim. The unpleasant tingle of an electrical discharge has found numerous applications. Galvanic and faradic currents were used for goiters, nervous conditions and sterility. Promulgation of such uses of electricity identified the charlatan. Yet, at the turn of the 19th century, Allan Burns, in his textbook on heart disease, had already counseled electric discharge for cardiac arrest.1 The use of electricity to regulate heart action has become not only an accepted but an indispensable . . .
Increased Stress-Induced Inflammatory Responses in Male Patients With Major Depression and Increased Early Life Stress
Authors: Thaddeus Pace
Journal: American Journal of Psychiatry (2006)

Objective: The authors sought to determine innate immune system activation following psychosocial stress in patients with major depression and increased early life stress. Method: Plasma interleukin (IL)-6, lymphocyte subsets, and DNA binding of nuclear factor (NF)-kB in peripheral blood mononuclear cells were compared in medically healthy male subjects with current major depression and increased early life stress (N=14) versus nondepressed male comparison subjects (N=14) before and after completion of the Trier Social Stress Test. Results: Trier Social Stress Test-induced increases in IL-6 and NF-κB DNA-binding were greater in major depression patients with increased early life stress and independently correlated with depression severity, but not early life stress. Natural killer (NK) cell percentages also increased following stress. However, there were no differences between groups and no correlation between NK cell percentage and stress-induced NF-κB DNA-binding or IL-6. Conclusions: Male major depression patients with increased early life stress exhibit enhanced inflammatory responsiveness to psychosocial stress, providing preliminary indication of a link between major depression, early life stress and adverse health outcomes in diseases associated with inflammation.
Abstract 1427: IL6 trans-signaling robustly promotes the expansion and antitumor activity of CAR T cells
Authors: Peng Li, Zhiwu Jiang, Rui Liao, Zhaoyang Tang
Journal: Cancer Research (2019)

Abstract Chimeric antigen receptor T (CAR T) cell immunotherapy targeting CD19 positive B cells malignancies induces promising clinical remissions. However, the treatments are often accompanied with high levels of IL-6 characterized cytokine release syndrome (CRS). Previous studies had shown that sIL-6R are constitutively present in high concentrations in serum. Therefore, when the level of IL-6 is elevated (above nomogram per ml), sIL-6R combines with IL6 to form the IL-6/sIL-6R complex (trans-signaling). The IL-6 trans-signaling plays important roles in regulating immune responses, cell survival, apoptosis, and proliferation. To our knowledge, comprehensive assessment of the IL-6 signaling in biologic functions of CAR T has not been well addressed. We thus tested whether the IL-6 trans-signaling promotes expansion and anti-tumor activity of CAR T. We found that the levels of serum IL-6 and IL-6/sIL-6R complex were positively correlated with anti-CD19 CAR T cell expansion and anti-leukemia response in patients. To simulate the IL-6 trans-signaling, we next constructed a constitutively expression of Hyper IL-6 (HIL-6) with various CAR T cells. Anti-tumor efficacy of HIL-6-CAR T cells were confirmed in leukemia (anti-CD19) and solid tumors (anti-MUC1 and anit-GPC3 CAR T cells targeting lung cancer and hepatocellular carcinoma, respectively). Our results demonstrate that HIL-6-CAR T cells are more effective for suppressing tumor growth and more persistent in xenograft models. Transcriptomic profiling analysis revealed that the expression of genes that facilitate T-cell migration, early memory differentiation and the IL-6/GP130/STAT3 signaling was upregulated in HIL-6 simulated CAR T cells compared to the ones without HIL-6 overexpression. Because IL-6 trans-signaling activates downstream signaling via GP130, we also generated a novel CAR vector with constituted GP130 activation and demonstrated the CAR T cells were superior in anti-tumor activity with delayed xGVHD in xenograft models of leukemia, lung cancer and liver cancer. Taken together, these results showed that IL-6 trans-signaling can significantly enhanced the expansion anti-tumor activity of CAR T cells via GP130/STAT3 activation and GP130/CAR T may have the potential to promote anti-tumor effects with reduced toxicity in vivo. Keywords: Chimeric antigen receptor T, cytokine release syndrome, IL-6 trans-signaling, GP130 Citation Format: Peng Li, Zhiwu Jiang, Rui Liao, Zhaoyang Tang. IL6 trans-signaling robustly promotes the expansion and antitumor activity of CAR T cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1427.
Evolution and the cardiac patient
Authors: P. HARRIS
Journal: Cardiovascular Research (1983)

Journal Article Evolution and the cardiac patient Get access PETER HARRIS PETER HARRIS From the Department of Cardiac Medicine, Cardiothoracic Institute, 2 Beaumont Street, W1N2DX Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 17, Issue 7, July 1983, Pages 373–378, https://doi.org/10.1093/cvr/17.7.373 Published: 01 July 1983
A study of REGN3767, an anti-LAG-3 antibody, alone and in combination with cemiplimab (REGN2810), an anti-PD1 antibody in advanced cancers.
Authors: Kyriakos P. Papadopoulos, Nehal Lakhani, Melissa Lynne Johnson, Haeseong Park, Ding Wang, Timothy A. Yap, Kathleen N. Moore, Tasha Nicholle Sims, Chetachi A. Emeremni, Maria Karasarides, Glenn S. Kroog
Journal: Journal of Clinical Oncology (2019)

TPS41 Background: Lymphocyte activation gene 3 (LAG-3) is an immune checkpoint receptor with a biological role in T-cell regulation. Analysis of immune-cell infiltrates from human tumors show that a subset of CD4+ and/or CD8+ cells co-express LAG-3 and PD-1 and may be associated with decreased T-cell effector function and tumor escape (Baitsch, 2011; Jie, 2013). Preclinical models provide evidence that dual inhibition of LAG-3 and PD-1 blockade offer synergistic anti-tumor effects and suggest a promising immunotherapy combination that warrants clinical investigation (Woo, 2012). This first in human study will evaluate the safety and efficacy of REGN3767 alone and in combination with cemiplimab in advanced malignancies. Methods: Phase 1 study enrolling patients with advanced malignancies. Dose escalation phase employs a modified 3+3 (4+3) design to assess the tolerability and pharmacokinetics (PK) of REGN3767 monotherapy and in combination with cemiplimab. Monotherapy and combination therapy are exploring multiple escalating REGN3767 dose levels. After tolerability and PK evaluation, doses of REGN3767 will be selected for monotherapy and combination therapy tumor-specific expansion cohorts. Solid tumor expansion cohorts will enroll per Simon’s two-stage design to evaluate safety and preliminary efficacy. Lymphoma expansion cohorts will enroll 15 patients. Patients who are anti-PD-1/PD-L1 therapy naïve and experienced are eligible for separate cohorts. Patients previously exposed to anti-LAG-3 therapy are not eligible. The primary objectives are the determination of the recommended dose for expansion (dose escalation) and ORR (dose expansion). Secondary objectives include characterization of PK and immunogenicity in all patients, as well as anti-tumor efficacy in dose escalation, and safety in dose expansion. This trial is actively enrolling eligible patients in the US, UK, Ireland, and South Korea. 1. Baitsch L et al. J Clin Investig. 2011;121:2350–2360. 2. Jie HB et al. Br J Cancer. 2013;109:2629–2635. 3. Woo SR et al. Cancer Res. 2012;72(4): 917–927. Clinical trial information: NCT03005782.
Serratia marcescens arthritis requiring amputation
Authors: E. Atlas
Journal: JAMA (1968)

A case of pyogenic arthritis caused by the organism<i>Serratia marcescens</i>is believed to be the first reported in the American literature. The patient presented initially with ocular signs, following by calf pain and tenderness, mistakenly interpreted as thrombophlebitis, and finally refractory pyogenic arthritis which led to amputation.
Suicide in India: from criminalisation to compassion
Authors: None The Lancet
Journal: The Lancet (2014)

The Indian Government has announced that it will overturn Section 309, a controversial law criminalising suicide. The announcement follows a 2008 report from the Indian Law Commission that recommended repeal of the "anachronistic" statute, mandating that people attempting suicide would be presumed to be suffering from mental illness and thus not liable for punishment.
MCJ deficiency results in gut barrier dysfunction and macrophage-elicited inflammation following ethanol consumption, facilitating alcoholic endotoxemia
Authors: Naroa Goikoetxea-Usandizaga, Marc Clos, Leticia Abecia, David Fernández Ramos, Miguel Pascual Itoiz, Ainize Peña Cearra, Begoña Rodriguez Iruretagoyena, Maider Bizkarguenaga, Diego Barriales, Marina Serrano-Macia, Sofia Lachiondo-Ortega, Rubén Rodríguez Agudo, Maria Mercado-Gómez, Oscar Lorenzo, Mercedes Rincón, Juan Falcon-Perez, Marta Varela-Rey, Franz Martin-Bermudo, Juan Anguita, María Luz Martínez-Chantar
Journal: Journal of Hepatology (2020)
Omission in Figure Legend.
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FIBRIN FERMENT IN MILK.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dietetics for Nurses.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: BMJ (1958)

I am the only one who belongs to the depressed class.I have been ejected from an overseas Service," said Dr. J. REvANs, who also summed up the discussion.He suggested that having a pool of "two-years men" might be doomed unless there was a conjoint board between the regional boards, universities, and overseas territories, so that the employing authorities knew the men who were coming to them.The PRESIDENT, in closing the conference, said that what the Association had in mind in convening the meeting was that it might enable Professor Mekie's committee at a later date to approve some action which might be useful in solving the problem.At the present moment there was considerable British influence in determining the shape which medicine would take in the colonial territories; but, unless that British influence was reinforced, the form which it eventually took would not be British, and might well be inspired from sources which at the moment none present would approve.It was true that no one had made any concrete sugges- tion which might help the general-duty officers of the Colonial Medical Service, and that responsibility rested squarely on the Government.However, it was difficult to see why medical schools or universities could not be per- suaded to adopt some of the schemes which had been propounded.
The risk of hepatitis B among select employee groups in an urban hospital
Authors: J. F. Jovanovich
Journal: JAMA (1983)

Hospital employees are at various degrees of risk for development of hepatitis B infections. A retrospective review of surveillance records in five clinical areas at high risk for hepatitis B exposure was carried out to determine its prevalence and incidence in each area. The area surveyed with the highest risk was the emergency department. It was followed, in descending order, by the operating room, the medical and surgical intensive care units, and the dentistry—oral surgery clinic. The surveyed area at the lowest risk was the hemodialysis unit. Strict infection-control guidelines probably minimize the employees' risk to hepatitis in the hemodialysis unit. In the emergency department, however, employees may be increasingly exposed to hepatitis B by dealing with life-threatening problems in an uncontrolled setting. (<i>JAMA</i>1983;250:1893-1894)
Coatesville Physician Sentenced.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Do toxic tetrapeptides play a role in fatal viral diseases?
Authors: Y. Becker
Journal: JAMA (1981)

CERTAIN viruses, such as the hemorrhagic fever viruses, arenaviruses, and togaviruses, are known to cause high mortality in human populations. Marburg and Ebola viruses cause death in most infected persons. During the smallpox era, there was a high fatality rate, and even today, more common viruses, such as influenza virus, can be fatal in young children and elderly people. Attempts to develop antiviral compounds have not as yet yielded a substance that can cure viral infections in the same way that antibiotics cure bacterial infections. In virus diseases with a high mortality, little can be done to save the patients in view of the high pathogenicity and morbidity of the viruses. Analysis of the pathological findings in patients who died after a virus infection indicated that organs were affected in which virus multiplication did not take place. Patients who died of smallpox in the first week of illness often showed
USE OF SALINE IN SOLUTIONS FOR LOCAL ANESTHESIA
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal