tbuckley/cabot-search huggingface dataset:
Norepinephrine turnover in the heart and spleen of the cardiomyopathic Syrian hamster.
Authors: M JSole, C MLo, C WLaird, E HSonnenblick, R JWurtman
Journal: Circulation Research (1975)

Although a reduction in myocardial norepinephrine stores in cardiac hypertrophy and congestive failure is well documented, norepinephrine turnover has been inadequately studied in such hearts. We compared norepinephrine turnover in control and cardiomyopathic hamsters by following the decline in specific activity of myocardial norepinephrine after labelling with an intraperitoneal tracer dose of 3H-norepinephrine. Adult myocardial norepinephrine concentrations were not attained until 4 weeks of age in both strains. There was no difference in the rate of constant (K) for myocardial norepinephrine turnover (0.107+/-0.004 hours-1 vs. 0.100+/-0.005 hours-1) in the two strains of hamsters during the neonatal period. In young control hamsters, K fell to 0.064+/-0.004 hours-1, but that for age-matched hamsters with mild cardiac hypertrophy was 0.102+/-0.001 hours-1 (P less than 0.001). There was little change in K as control hamsters aged. With the development of more severe hypertrophy in cardiomyopathic hamste...
Focusing on Core Patient-Reported Outcomes in Cancer Clinical Trials—Response
Authors: Paul G. Kluetz, Elektra J. Papadopoulos, Laura Lee Johnson, Martha Donoghue, Virginia E. Kwitkowski, Wen-Hung Chen, Rajeshwari Sridhara, Ann T. Farrell, Patricia Keegan, Geoffrey Kim, Richard Pazdur
Journal: Clinical Cancer Research (2016)

We thank Grønvold and colleagues for comments on our publication presenting a U.S. regulatory perspective on patient-reported outcome (PRO) data in cancer clinical trials (1). In this article, we propose to focus our analysis of submitted PRO data on symptomatic adverse events, symptoms of disease, and physical function as a starting point to address calls to incorporate rigorous PRO data in FDA product labeling. Information in FDA product labeling must be generated from well-defined and reliable assessments and should aim to distinguish the effect of the drug from other influences (2, 3).Tailoring PRO assessments using a selection of questions from an item library or item bank can provide needed flexibility to address increasing heterogeneity in disease and treatment contexts. We use the PRO version of the NCI's Common Terminology Criteria for Adverse Events (PRO-CTCAE) and PRO Management Information System physical function measures as examples of an item library and item bank, respectively. We acknowledge the PRO tools cited in our article and the FDA's clinical outcome assessment compendium (4) are not the only tools available, and we encourage sponsors to engage FDA early in drug development to discuss their PRO measurement strategy.Our article does not advocate for analysis of patient-reported symptoms alone. We propose analyzing physical function as a core PRO concept that is important to patients and can capture the tradeoff between disease symptom improvement and symptomatic adverse events. Furthermore, although we propose to focus on three core concepts to analyze for labeling consideration, we are clear that they may not be the only concepts to assess in a clinical trial. Other concepts may be needed to address trial objectives, and international drug development stakeholders often request other health-related quality of life domains and/or utility scores to provide supportive data on the broader patient experience.Similar to Grønvold and colleagues, we favor a thoughtful combination of static questionnaires and item banks or libraries to create a balanced, flexible, and modular approach to PRO assessment to address targeted trial objectives and accommodate the needs of multiple stakeholders. Rigorous PRO collection to minimize missing data and international collaboration toward best practices for trial design and PRO data analysis methods remains critical. As our article states, "the goal should be to achieve a comprehensive evaluation of the patient experience most affected by the therapy, while maximizing the relevance of individual questions and minimizing overall burden and duplication."See the original Letter to the Editor, p. 5617No potential conflicts of interest were disclosed.
THE WATER-SUPPLY OF CITIES.
Authors: C. F. ULRICH
Journal: JAMA (1898)

bring into tho world nine beings, as I have stated, to live a lifetime of suffering.An insane man may go home to his family during his better periods from a hospital and resume his family relations and cause the birth of other beings, who stand much more than a chance of a miserable life.And in very few States is this discouraged.The imbecile may marry, and marry pretty often, and the taxpayer supports the fruits of such a union, often with money that represents much self-denial, and perhaps should be spent in the better education of his own promising offspring.A woman recently wrote me, "My husband died, and as I had no other means of getting a living, I married again.That man left me and I have married another!"She wished to dispose of her imbecile boy.As I have already said, there are three methods of meeting this evil. 1.The woman may be seques- trated.The question of "personal liberty" may come up here.But personal liberty is not desirable when it can bring nothing but harm to its possessor.Let the imbecile woman gratify her maternal instinct of
Complementary Role of 68Ga–Prostate-Specific Membrane Antigen and 18F-FDG PET/CT for Evaluation of Metastases and Treatment Response in Renal Cell Carcinoma
Authors: Duygu Has Simsek, Caner Civan, Selcuk Erdem, Yasemin Sanli
Journal: Clinical Nuclear Medicine (2021)

Abstract We present a case of clear cell renal cell carcinoma, which demonstrates complementary FDG and prostate-specific membrane antigen (PSMA) uptake on metastases in PET/CT, as an example of tumor heterogeneity. The patient had non–FDG-avid lung and bone metastases with PSMA uptake, whereas metastatic cervical and axillary lymph nodes showed vice versa, and skeletal muscle metastasis to vastus lateralis, which is an unusual region for metastasis, showed both PSMA and FDG positivity. In response assessment, mix response was detected. It seems that 68 Ga-PSMA and 18 F-FDG may have a complementary role in demonstration of metastasis accurately and assessment of treatment response in clear cell renal cell carcinoma.
Diagnosis of prosthetic mitral valve malfunction with combined echo-phonocardiography.
Authors: B RBrodie, WGrossman, LMcLaurin, P JStarek, ECraige
Journal: Circulation (1976)

Fifty-three patients were studied with combined echo-phonocardiography or phonocardiography alone following prosthetic valve replacement. In sixteen of these patients, clinical deterioration developed, and all subsequently underwent cardiac catheterization and/or surgery. Two patients came to autopsy. Included in this group of sixteen patients were five with obstructed prosthesis, six with paravalvular regurgitation, and five with left ventricular dysfunction. Measurements were made of the time interval from the aortic valve closure sound to the peak opening of the mitral prosthesis determined echocardiographically or to the mitral prosthetic opening click (A2-MVO). Echocardiographic studies of left ventricular wall motion were also performed. The A2-MVO interval was significantly shortened (P less than 0.01) with prosthetic valve obstruction (.05 +/- .02 sec) and paravalvular regurgitation (.05 +/- .01 sec) compared with normally functioning prostheses (Starr-Edwards ball valves .10 +/- .02 sec, Lillehei...
Hemodynamic, renal, and hormonal responses to brain natriuretic peptide infusion in patients with congestive heart failure.
Authors: MYoshimura, HYasue, EMorita, NSakaino, MJougasaki, MKurose, MMukoyama, YSaito, KNakao, HImura
Journal: Circulation (1991)

BACKGROUNDThis study was designed to examine the hemodynamic, renal, and hormonal effects of brain natriuretic peptide (BNP) infusion in patients with congestive heart failure (CHF) and in control subjects.METHODS AND RESULTSWe infused synthetic human BNP at a rate of 0.1 micrograms/kg/min. BNP infusion decreased pulmonary capillary wedge pressure (control, from 5 +/- 1 to 2 +/- 1 mm Hg, p less than 0.01; CHF, from 21 +/- 3 to 14 +/- 4 mm Hg, p less than 0.05) and systemic vascular resistance (control, from 1,264 +/- 75 to 934 +/- 52 dyne.sec.cm-5; CHF, from 2,485 +/- 379 to 1,771 +/- 195 dyne.sec.cm-5; p less than 0.01, respectively) and increased stroke volume index (control, from 49.9 +/- 2.7 to 51.5 +/- 2.3 ml/m2, p = NS; CHF, from 25.6 +/- 3.8 to 32.0 +/- 3.9 ml/m2, p less than 0.01). BNP infusion significantly increased urine volume (control, from 2.3 +/- 0.7 to 7.5 +/- 1.9 ml/min; CHF, from 0.8 +/- 0.2 to 5.3 +/- 1.0 ml/min; p less than 0.01, respectively), excretion of sodium (control, from 79.2 +...
Sutimlimab in Cold Agglutinin Disease
Authors: Alexander Röth, Wilma Barcellini, Shirley D’Sa, Yoshitaka Miyakawa, Catherine M. Broome, Marc Michel, David J. Kuter, Bernd Jilma, Tor H.A. Tvedt, Joachim Fruebis, Xiaoyu Jiang, Stella Lin, Caroline Reuter, Jaime Morales-Arias, William Hobbs, Sigbjørn Berentsen
Journal: New England Journal of Medicine (2021)

Cold agglutinin disease is a rare autoimmune hemolytic anemia characterized by hemolysis that is caused by activation of the classic complement pathway. Sutimlimab, a humanized monoclonal antibody, selectively targets the C1s protein, a C1 complex serine protease responsible for activating this pathway.
Type 1 conventional dendritic cell fate and function are controlled by DC-SCRIPT
Authors: Shengbo Zhang, Hannah D. Coughlan, Mitra Ashayeripanah, Simona Seizova, Andrew J. Kueh, Daniel V. Brown, Wang Cao, Nicolas Jacquelot, Angela D’Amico, Andrew M. Lew, Yifan Zhan, Christopher J. Tonkin, Jose A. Villadangos, Gordon K. Smyth, Michaël Chopin, Stephen L. Nutt
Journal: Science Immunology (2021)

DC-SCRIPT is a key transcription factor controlling type 1 conventional dendritic cell fate and function.
Cardiac myosin heavy chain mRNA expression and myocardial function in the mouse heart.
Authors: W ANg, I LGrupp, ASubramaniam, JRobbins
Journal: Circulation Research (1991)

The vertebrate heart contains two myosin heavy chain isoforms, alpha and beta, which are differentially expressed. To establish a murine model for gene-targeting experiments, we defined the precise temporal expression of the myosin isoforms during cardiogenesis and obtained quantitative measurements of cardiac performance. The relative levels of the alpha- and beta-cardiac transcripts were determined by isolating the RNA from the hearts of CD-1 mice during development and hybridizing the preparations to probes that detect specifically the alpha- or beta-cardiac myosin heavy chain mRNAs. The data indicate that, although both isoforms are present from the onset of cardiogenesis, the beta-isoform predominates during embryogenesis and fetal development. This relation is reversed after the first day of life with a significant drop in the absolute transcript levels during the switch; and alpha/beta ratio of 16:1 is maintained in the neonate, and the relatively high levels of the alpha-transcript remain througho...
From the authors
Authors: L. Welker
Journal: European Respiratory Journal (2005)

We would like to thank S. Greco and coworkers for their comments on our paper about the predictive value of bronchoalveolar lavage (BAL) cell differentials in the diagnosis of interstitial lung disease (ILD) [1].In their study, which they discuss in their letter to the Editors, they tested the feasibility of our data for the differential diagnosis of pulmonary tuberculosis (TB) and sarcoidosis.In contrast to our study, they retrospectively analysed 88 patients with biopsy-proven sarcoidosis and 76 patients with culture-positive pulmonary TB.
Modulation of an inactivating human cardiac K+ channel by protein kinase C.
Authors: K TMurray, S AFahrig, K KDeal, S SPo, N NHu, D JSnyders, M MTamkun, P BBennett
Journal: Circulation Research (1994)

The transient outward current (ITO) is an important repolarizing component of the cardiac action potential. In native cardiac myocytes, ITO is modulated after activation of protein kinase C, although the molecular nature of this effect is not well understood. A channel recently cloned from human ventricular myocardium (Kv1.4, HK1) produces a rapidly inactivating K+ current, which has phenotypic similarities to the 4-aminopyridine-sensitive component of ITO. Therefore, we examined whether this recombinant channel was also modulated by protein kinase C activation by investigating the effects of the diacylglycerol analogue phorbol 12-myristate 13-acetate (PMA) on Kv1.4 K+ current expressed in Xenopus oocytes. At a concentration of 10 nmol/L, PMA caused a biphasic response with an initial increase (14 +/- 4%, mean +/- SEM) in current, which peaked in 14 minutes. This was followed by a significant reduction (40 +/- 11%) in the current within 30 minutes. There was no significant change in cell membrane electric...
Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia
Authors: Daria V Babushok, Timothy S Olson, Monica Bessler
Journal: New England Journal of Medicine (2015)

In patients with acquired aplastic anemia, destruction of hematopoietic cells by the immune system leads to pancytopenia.Patients have a response to immunosuppressive therapy, but myelodysplastic syndromes and acute myeloid leukemia develop in about 15% of the patients, usually many months to years after the diagnosis of aplastic anemia. METHODSWe performed next-generation sequencing and array-based karyotyping using 668 blood samples obtained from 439 patients with aplastic anemia.We analyzed serial samples obtained from 82 patients. RESULTSSomatic mutations in myeloid cancer candidate genes were present in one third of the patients, in a limited number of genes and at low initial variant allele frequency.Clonal hematopoiesis was detected in 47% of the patients, most frequently as acquired mutations.The prevalence of the mutations increased with age, and mutations had an age-related signature.DNMT3A-mutated and ASXL1-mutated clones tended to increase in size over time; the size of BCOR-and BCORL1-mutated and PIGA-mutated clones decreased or remained stable.Mutations in PIGA and BCOR and BCORL1 correlated with a better response to immunosuppressive therapy and longer and a higher rate of overall and progression-free survival; mutations in a subgroup of genes that included DNMT3A and ASXL1 were associated with worse outcomes.However, clonal dynamics were highly variable and might not necessarily have predicted the response to therapy and long-term survival among individual patients. CONCLUSIONSClonal hematopoiesis was prevalent in aplastic anemia.Some mutations were related to clinical outcomes.A highly biased set of mutations is evidence of Darwinian selection in the failed bone marrow environment.The pattern of somatic clones in individual patients over time was variable and frequently unpredictable.
Circulatory reflexes from carotid and extracarotid baroreceptor areas in man.
Authors: GMancia, AFerrari, LGregorini, RValentini, JLudbrook, AZanchetti
Journal: Circulation Research (1977)

The carotid sinus baroreceptor reflex was studied in 11 normotensive subjects, using a variable pressure neck chamber and correcting for imperfect pressure transmission to the carotid sinus. Decreased carotid baroreceptor stimulation caused a sustaineded rise in arterial pressure, and increased carotid baroreceptor stimulation caused a sustain fall. The responses were in linear relation to the stimulus, and, after reaching the steady state, greater for the reduced than for the increased baroreceptor stimulation. Thus the carotid sinus baroreceptor reflex of the normotensive man is an effective antihypotensive and antihypertensive feedback system, though the former function may have more sensitivity. The increased and decreased baroreceptor stimulation by the neck chamber also caused bradycardia and tachycardia which were modest in magnitude and often transient. In eight subjects the reflex changes in heart rate induced by the neck chamber were compared with those induced by altering transmural pressure no...
Open access echocardiography
Authors: E. C. Corbella, J. J. R. Alonso, C. Q. Luzon, M. Gonzalez
Journal: BMJ (1995)

Despite these findings and the well documented data on adults, pulse oximetry and cardiac monitoring have not been universally used in children undergoing endoscopy under sedation.4Clearly, if paediatric endoscopy is performed in this way similar recommendations concerning careful monitoring and supplemental oxygen must apply.There is, however, a safer and possibly better alternative.After witnessing several major hypoxic events and a respiratory arrest in centres where paediatric gastrointestinal endoscopy is performed under sedation, we have made it our policy to undertake these procedures under short general anaesthesia.This permits both detailed cardio- respiratory monitoring and constant supervision of the patient's airway by the anaesthetist.The procedure is well tolerated (and much preferred by those who have previously undergone endoscopy or jejunal biopsy under sedation) and can usually be carried out on a day case basis.General anaes- thesia allows the endoscopist to concentrate on the examination without distraction, and therapeutic interventions such as dilatation of an oesophageal stricture or injection of oesophageal varices can be undertaken during the same session.In a personal audit of over 300 diagnostic or therapeutic flexible gastrointestinal endoscopies performed in children aged 1 month to 17 years under general anaesthesia since January 1994 there were no major adverse events and all patients recovered fully.The patients included children with severe cerebral palsy, congenital heart disease, and other complex medical problems, who are at greater risk of cardiorespiratory disturbances.
PRISMA Reporting Guidelines for Meta-analyses and Systematic Reviews
Authors: Shipra Arya, Amy H. Kaji, Marja A. Boermeester
Journal: JAMA Surgery (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Therapeutic and Diagnostic Translation of Extracellular Vesicles in Cardiovascular Diseases
Authors: Susmita Sahoo, Marta Adamiak, Prabhu Mathiyalagan, Franziska Kenneweg, Sabine Kafert-Kasting, Thomas Thum
Journal: Circulation (2021)

Exosomes are small membrane-bound vesicles of endocytic origin that are actively secreted. The potential of exosomes as effective communicators of biological signaling in myocardial function has previously been investigated, and a recent explosion in exosome research not only underscores their significance in cardiac physiology and pathology, but also draws attention to methodological limitations of studying these extracellular vesicles. In this review, we discuss recent advances and challenges in exosome research with an emphasis on scientific innovations in isolation, identification, and characterization methodologies, and we provide a comprehensive summary of web-based resources available in the field. Importantly, we focus on the biology and function of exosomes, highlighting their fundamental role in cardiovascular pathophysiology to further support potential applications of exosomes as biomarkers and therapeutics for cardiovascular diseases.
Baroreflex sensitivity and heredity in essential hypertension.
Authors: R JParmer, J HCervenka, R AStone
Journal: Circulation (1992)

BACKGROUNDAbnormalities in baroreflex control of heart rate may be important in the pathogenesis of essential hypertension.METHODS AND RESULTSTo investigate the influence of heredity on baroreflex function, we measured baroreflex sensitivity in 40 untreated patients with essential hypertension grouped by the presence (FH+) or absence (FH-) of a family history of hypertension and in 24 normotensive counterparts. Baroreflex sensitivity was assessed by both high-pressure (phenylephrine bolus) and low-pressure (amyl nitrite inhalation) stimuli. Subject groups were matched for age, blood pressure, body weight, and race. Baroreflex sensitivity (in milliseconds per millimeter of mercury) assessed by amyl nitrite inhalation was 24.3 +/- 2.8 in FH- normotensives, 12.3 +/- 1.7 in FH+ normotensives, 15.4 +/- 3.3 in FH- hypertensives, and 8.1 +/- 1.2 in FH+ hypertensives. Baroreflex sensitivity assessed by phenylephrine bolus was 28.8 +/- 5.6 in FH- normotensives, 19.3 +/- 2.8 in FH+ normotensives, 19.1 +/- 2.0 in FH...
Factors influencing the long-term prognosis of treated patients with variant angina.
Authors: D DWaters, D DMiller, JSzlachcic, ABouchard, MMéthé, JKreeft, PThéroux
Journal: Circulation (1983)

To determine the prognosis of variant angina and the factors influencing it, 169 consecutive patients hospitalized in our coronary unit were followed for a mean of 15.3 months (range 1 to 68). Survival at 1, 2, and 3 years was 95%, 90%, and 87%, respectively; survival without myocardial infarction was 80%, 78%, and 75%. Twenty of the 22 myocardial infarctions and eight of the 14 deaths occurred within the first 3 months. Mantel-Haenszel log-rank analysis demonstrated that coronary disease, ventricular function, and the degree of disease activity were significant interdependent variables that influenced both survival and survival without infarction. At 1, 2, and 3 years, survival for patients with multivessel disease was 81%, 76%, and 66%; for patients with one-vessel disease, 97%, 92%, and 92%; and for patients without stenoses greater than or equal to 70%, 98% at each year (p = .0003). Survival without infarction at 1 year was 88% in patients with no stenoses greater than or equal to 70% and 82% in patie...