tbuckley/cabot-search huggingface dataset:
DECONGESTION, QUALITY OF LIFE, AND CLINICAL OUTCOMES AMONG PATIENTS HOSPITALIZED FOR HEART FAILURE WITH REDUCED VERSUS PRESERVED EJECTION FRACTION
Authors: Anthony Peters, Robert John Mentz, Jie Sun, Josephine Harrington, Marat Fudim, Brooke Alhanti, Adrian F. Hernandez, Javed Butler, Randall C. Starling, Christopher M. O’Connor, Stephen J. Greene
Journal: Journal of the American College of Cardiology (2022)
HSR22-149: Adverse Events Among Cancer Patients Treated With a Combination of Nivolumab and Ipilimumab as Compared to Nivolumab Monotherapy: A Systematic Review and Meta-Analysis
Authors: Shweta Kamat, Jay Patel, Britny Brown, Ami Vyas
Journal: Journal of the National Comprehensive Cancer Network (2022)

"HSR22-149: Adverse Events Among Cancer Patients Treated With a Combination of Nivolumab and Ipilimumab as Compared to Nivolumab Monotherapy: A Systematic Review and Meta-Analysis" published on 31 Mar 2022 by National Comprehensive Cancer Network.
CARDIOVASCULAR OUTCOMES OF ST-ELEVATION MYOCARDIAL INFARCTION (STEMI) PATIENTS WITHOUT STANDARD MODIFIABLE RISK FACTORS (SMURF-LESS): THE INTERMOUNTAIN HEALTHCARE EXPERIENCE
Authors: Jeffrey L. Anderson, Stacey Knight, Heidi Thomas May, Viet T. Le, Jawad Almajed, Tami L. Bair, Kirk U. Knowlton, J. Brent Muhlestein
Journal: Journal of the American College of Cardiology (2022)
PSYCHOSOCIAL CHARACTERISTICS OF SMIDT HEART INSTITUTE TAKOTSUBO REGISTRY PARTICIPANTS
Authors: Okezi Obrutu, Jenna Maughan, Benita Tjoe, Romana Herscovici, Prizzi Moy, Natalie Rojas, Paul Marano, Janet Wei, Chrisandra Shufelt, Thomas Rutledge, C. Noel Bairey Merz
Journal: Journal of the American College of Cardiology (2022)
Solitary Nasopharyngeal Metastasis From Papillary Thyroid Carcinoma Shown on FDG PET/CT
Authors: Anqi Xu, Xiao Jie, Yan Xiu, Hongcheng Shi
Journal: Clinical Nuclear Medicine (2022)

Abstract It is very rare for papillary thyroid cancer metastasize to nasopharynx. We report FDG PET/CT findings of a solitary nasopharyngeal metastasis from papillary thyroid cancer 4 decades after the initial diagnosis in a 66-year-old woman, which mimics nasopharyngeal carcinoma. The final diagnosis was confirmed by pathological examination from the biopsy of nasopharyngeal lesion.
SYSTOLIC HEART FAILURE PATIENTS HOSPITALIZED WITH COPD EXACERBATION HAVE A GREATER RISK FOR CARDIOGENIC SHOCK AND MACE COMPARED TO PATIENTS WITH DIASTOLIC HEART FAILURE
Authors: Leanne Pereira, Michael A. Fatuyi, Vahid Namdarizandi, Awfa Zain Elabidin, Vivek Sharma, Leonid Khokhlov, Kamal Shemisa
Journal: Journal of the American College of Cardiology (2022)
Hyperpigmentation in Vitamin B <sub>12</sub> Deficiency
Authors: Sandeep Maharajh, Surujpal Teelucksingh
Journal: New England Journal of Medicine (2022)

A 59-year-old man presented with fatigue and hyperpigmentation on his palms and soles. Physical examination showed a smooth tongue with areas of darkening. Laboratory tests showed pancytopenia, a low vitamin B12 level, and an elevated intrinsic factor antibody level, findings consistent with vitamin B12 deficiency due to autoimmune gastritis.
Risk factors for metastatic cutaneous squamous cell carcinoma: Refinement and replication based on 2 nationwide nested case-control studies
Authors: Selin Tokez, Zoe C. Venables, Loes M. Hollestein, Hongchao Qi, Edo M. Bramer, Barbara Rentroia-Pacheco, Renate R. van den Bos, Brian Rous, Irene M. Leigh, Tamar Nijsten, Antien L. Mooyaart, Marlies Wakkee
Journal: Journal of the American Academy of Dermatology (2022)

Risk factors for cutaneous squamous cell carcinoma (cSCC) metastasis have been investigated only in relatively small data sets.To analyze and replicate risk factors for metastatic cSCC.From English and Dutch nationwide cancer registry cohorts, metastatic cases were selected and 1:1 matched to controls. The variables were extracted from pathology reports from the National Disease Registration Service in England. In the Netherlands, histopathologic slides from the Dutch Pathology Registry were revised by a dermatopathologist. Model building was performed in the English data set using backward conditional logistic regression, whereas replication was performed using the Dutch data set.In addition to diameter and thickness, the following variables were significant risk factors for metastatic cSCC in the English data set (n = 1774): poor differentiation (odds ratio [OR], 4.56; 95% CI, 2.99-6.94), invasion in (OR, 1.69; 95% CI, 1.05-2.71)/beyond (OR, 4.43; 95% CI, 1.98-9.90) subcutaneous fat, male sex (OR, 2.59; 95% CI, 1.70-3.96), perineural/lymphovascular invasion (OR, 2.12; 95% CI, 1.21-3.71), and facial localization (OR, 1.57; 95% CI, 1.02-2.41). Diameter and thickness showed significant nonlinear relationships with metastasis. Similar ORs were observed in the Dutch data set (n = 434 cSCCs).Retrospective use of pathology reports in the English data set.cSCC staging systems can be improved by including differentiation, clinical characteristics such as sex and tumor location, and nonlinear relationships for diameter and thickness.
Pellagra
Authors: Murali Alagesan, Yoganathan Chidambaram
Journal: New England Journal of Medicine (2022)

A 48-year-old woman from rural India presented with a 6-month history of diarrhea and a symmetric, photosensitive rash on her neck and forearms. On the basis of her symptoms and the typical appearance of the Casal’s necklace rash, pellagra was diagnosed. Her condition improved with intravenous vitamin B complex.
Covid-19: Is the UK heading for another omicron wave?
Authors: Elisabeth Mahase
Journal: BMJ (2022)

Covid-19: Is the UK heading for another omicron wave?With covid cases and hospital admissions again rising, Elisabeth Mahase examines what is driving the trend Elisabeth MahaseAfter several weeks of decline, global covid-19 case numbers are rising again.Parts of Asia such as Hong Kong are experiencing huge and deadly surges of the virus. 1 In the UK, cases and hospital admissions, which had been falling since the omicron peak in January, are now increasing.The latest figures from NHS Test and Trace show that in England a total of 323 032 people tested positive for SARS-CoV-2 between 3 and 9 March 2022, an increase of 55.5% from the previous week.
CXCR6-based immunotherapy in autoimmune, cancer and inflammatory infliction
Authors: Tingting Li, Jie Pan, Hongqi Chen, Yongliang Fang, Yang Sun
Journal: Acta Pharmaceutica Sinica B (2022)

T cells, including both CD4+ and CD8+ T cells, play a pivotal role in mediating various inflammation and immune disorders. A long-standing challenge in T cell-based immunotherapy is to precisely inactivate or delete the pathogenic T cells in inflammation and autoimmune diseases, or to selectively expand the immunocompetent T cell in tumor or other immune compromised situations, without inducing global immunosuppression or zealous immune activation respectively. To achieve this, a specific marker is needed to differentiate the pathogenic or immunocompetent T cell among the rests. Indeed, recent progress of immunology strongly suggests that CXC chemokine receptor 6 (CXCR6, CD186) is such a kind of marker. Here, we review the emerging role of CXCR6 as a novel target for immunotherapy and discuss the underlying mechanism. We propose that CXCR6-based immunotherapy will play a significant role in autoimmune, nonalcoholic steatohepatitis (NASH), tumor, coronavirus disease 2019 (COVID-19) and even ageing-related inflammatory infliction.
IMPACT OF IN-HOSPITAL BLEEDING EVENTS ON MORTALITY IN STEMI PATIENTS WITH RADIAL PCI
Authors: Raunak M. Nair, Anirudh Kumar, Chetan Prakash Huded, Michael Joseph Johnson, Amar Krishnaswamy, A. Michael Lincoff, Venu Menon, Stephen Meldon, Grant W. Reed, Damon Kralovic, Samir R. Kapadia, Umesh Khot
Journal: Journal of the American College of Cardiology (2022)
NOVEL RABBIT ILIAC OPTICAL COHERENCE TOMOGRAPHY METHOD FOR SERIAL ASSESSMENT OF THE EFFICACY OF VASCULAR DISEASE THERAPIES
Authors: Mordechai Golomb, Allison L. Tsao, Patrick Boldenow, Matthew Hilden, Barbora Zvarova, scott Smith, Nick Rydberg, Lori Foley, Tarun Bomma, Diaa El din A. Hakim, Kevin J. Croce
Journal: Journal of the American College of Cardiology (2022)
OUTCOMES AND CHARACTERISTICS OF PATIENTS UNDERGOING PERICARDIOCENTESIS WITH CONCOMITANT BLOOD TRANSFUSION
Authors: Ruthvik Srinivasamurthy, Sundeep Kumar, Hiren Patel, Ali Ghani, Lolita Golemi, Akhil Mogalapalli, Sarika Kumari, Ammar Nasir, Sayed Tahir Hussain, Elsayed Abo-Salem
Journal: Journal of the American College of Cardiology (2022)
Intestinal Tuft-2 cells exert antimicrobial immunity via sensing bacterial metabolite N-undecanoylglycine
Authors: Zhen Xiong, Xiaoxiao Zhu, Jingjing Geng, Yuwei Xu, Runyuan Wu, Cunzhen Li, Dongdong Fan, Xiwen Qin, Ying Du, Yong Tian, Zusen Fan
Journal: Immunity (2022)
PEMBROLIZUMAB INDUCED MYOCARDITIS AND COMPLETE HEART BLOCK; A CASE REPORT
Authors: Olusola Olubowale, Ebubechukwu Ezeh, Esiemoghie J. Akhigbe, Kelechukwu U. Okoro, Mehair El-Hamdani, Paul I. Okhumale
Journal: Journal of the American College of Cardiology (2022)
TYPES OF ATRIAL FIBRILLATION AND DEVICE-RELATED THROMBUS AFTER LEFT ATRIAL APPENDAGE OCCLUSION DEVICE IMPLANTATION: A META-ANALYSIS
Authors: Chanavuth Kanitsoraphan, Chol Techorueangwiwat, Parthav Shah, Jason Kuniyoshi, Todd Nagamine, Witina Techasatian, Jihun Yeo, Somsupha Kanjanauthai
Journal: Journal of the American College of Cardiology (2022)
Colocolonic intussusception identified during endoscopy: an incidental diagnosis
Authors: Steve Hu, William K. Carson, Jaya Krishna Chintanaboina, Devang N. Prajapati
Journal: Endoscopy (2022)

A 42-year-old man with no prior medical history presented with perianal pain and pustular drainage over the course of 1 week. On physical examination, he had a perianal abscess with a draining sinus tract, but no abdominal tenderness to palpation. Laboratory tests showed severe iron deficiency anemia. As part of a workup for this, an upper gastrointestinal endoscopy was performed, which was unremarkable. Subsequently, a colonoscopy was performed, which revealed no mucosal inflammation but did show a large focal region of the mid-transverse colon, which spontaneously protruded and retracted ([Video 1]). To evaluate this further, a computed tomography (CT) scan was performed, which revealed a colocolonic intussusception of the transverse colon, without any focal neoplasm ([Fig. 1]). The patient's perianal abscess improved on antibiotics without the development of any further symptoms and he was discharged home.
COMBINING MULTIPLE CARDIOVASCULAR RISK PREDICTION MODELS IMPROVES MODEL PERFORMANCE: A NOVEL FLEXIBLE FRAMEWORK APPROACH APPLIED TO A CONTEMPORARY AND DIVERSE EHR COHORT
Authors: Aniket N. Zinzuwadia, Chunying Li, Hesam Dashti, Lin Chen, Brian Cade, Elizabeth Karlson, Samia Mora, Nina Paynter, Olga Demler
Journal: Journal of the American College of Cardiology (2022)
GEOGRAPHIC DISTRIBUTION &amp; CLINICAL OUTCOMES AMONG PATIENTS ADMITTED WITH TAKOTSUBO CARDIOMYOPATHY ACROSS THE UNITED STATES.
Authors: Michael A. Fatuyi, Awfa Zain Elabidin, Leanne Pereira, Vahid Namdarizandi, Vivek Sharma, Leonid Khokhlov, Mubarak H. Yusuf, Olukayode Ahmed Busari, Asimul H. Ansari, Kamal Shemisa
Journal: Journal of the American College of Cardiology (2022)
Evaluation of Trends in Preexposure Prophylaxis Prescriptions During the First 6 Months of the COVID-19 Pandemic in New York State
Authors: Thomas J. O’Grady, James M. Tesoriero, Yingchao Yuan, Thomas M. Grisham, Seung Jun Seo, Charles J. Gonzalez, Johanne E. Morne
Journal: JAMA Network Open (2022)
Endothelial OCT4 is atheroprotective by preventing metabolic and phenotypic dysfunction
Authors: Junchul Shin, Svyatoslav Tkachenko, Malay Chaklader, Connor Pletz, Kanwardeep Singh, Gamze B Bulut, Young min Han, Kelly Mitchell, Richard A Baylis, Andrey A Kuzmin, Bo Hu, Justin D Lathia, Olga Stenina-Adognravi, Eugene Podrez, Tatiana V Byzova, Gary K Owens, Olga A Cherepanova
Journal: Cardiovascular Research (2022)

Abstract Aims Until recently, the pluripotency factor Octamer (ATGCAAAT)-binding transcriptional factor 4 (OCT4) was believed to be dispensable in adult somatic cells. However, our recent studies provided clear evidence that OCT4 has a critical atheroprotective role in smooth muscle cells. Here, we asked if OCT4 might play a functional role in regulating endothelial cell (EC) phenotypic modulations in atherosclerosis. Methods and results Specifically, we show that EC-specific Oct4 knockout resulted in increased lipid, LGALS3+ cell accumulation, and altered plaque characteristics consistent with decreased plaque stability. A combination of single-cell RNA sequencing and EC-lineage-tracing studies revealed increased EC activation, endothelial-to-mesenchymal transitions, plaque neovascularization, and mitochondrial dysfunction in the absence of OCT4. Furthermore, we show that the adenosine triphosphate (ATP) transporter, ATP-binding cassette (ABC) transporter G2 (ABCG2), is a direct target of OCT4 in EC and establish for the first time that the OCT4/ABCG2 axis maintains EC metabolic homeostasis by regulating intracellular heme accumulation and related reactive oxygen species production, which, in turn, contributes to atherogenesis. Conclusions These results provide the first direct evidence that OCT4 has a protective metabolic function in EC and identifies vascular OCT4 and its signalling axis as a potential target for novel therapeutics.
Plasma proteins as a predictor of chronological age in people living with HIV: a cross-sectional study
Authors: Adriana Navas, Vasiliki Matzaraki, Quirijn de Mast, André J A M van der Ven, Leo A B Joosten, Mihai G Netea
Journal: The Lancet Healthy Longevity (2022)

BackgroundAgeing is associated with an impaired immune response and shares many physiological alterations observed in HIV chronic infection; therefore, we hypothesised that people living with HIV exhibit a premature ageing phenotype, reflected by age-related changes in the plasma proteome.MethodsWe profiled the plasma proteome in two cohorts of virally suppressed people living with HIV, the 2000HIV cohort (n=65; median age 53 years [IQR 45–60]; 91% male [n=597] and 8% female [n=59]) and the 200HIV cohort (n=218; 52 years [45–59]; 91% [n=199] and 9% [n=19]), and in 100 age-matched and sex-matched people without HIV, the 200FG cohort (n=100; 50 years [38–59]; 75% [n=75] and 25% [n=25]). Patients were recruited from the following Dutch HIV Treatment Centres: Radboudumc (Nijmegen), ErasmusMC (Rotterdam), Onze Lieve Vrouwe Gasthuis (Amsterdam), Elisabeth-TweeSteden Ziekenhuis (Tilburg). Clinical information was collected from all participants using standard questionnaires and interviews on lifestyle, health, and clinical symptoms, and samples from blood, urine, saliva and stool were obtained for further analytical measurements. We characterised the proteins that are associated with chronological age and explored the extent to which the plasma proteome predicts age in people with or without HIV. Using a multiplex proximity extension assay (Olink Proteomics), the relative abundance of 1472 proteins was assessed across four different panels (inflammatory, cardiometabolic, neurology, and oncology). The cohort of people without HIV was used to build a prediction model for age, based on elastic net regression and using a common proteomic signature between people living with HIV and people without HIV.FindingsThe number of proteins significantly associated with age was 569 in the 2000 HIV cohort, 322 in the 200 HIV cohort, and 101 in the 200FG cohort (adjusted p<0·05). 78 proteins were common to all cohorts and some of these proteins (LTBP2, EDA2R, WNT9A, NEFL, SCARF2, KLK4, GDF15, CXCL14, HAVCR1, and GFAP) are involved in immune-related processes and secretory senescence-associated phenotype. The correlation between proteomic age prediction and chronological age was 0·92 in 200FG, 0·82 in 2000 HIV, and 0·8 in 200 HIV (p<0·001). According to this proteomic-age predictive model, people living with HIV showed an increased inflammatory age compared with people without HIV.InterpretationThis targeted proteomics analysis showed a common proteomic signature of chronological age in people with HIV and people without HIV. This proteomic signature of age could predict premature ageing in people with HIV, which warrants further investigation of its role in the development of inflammatory comorbidities and disease severity.FundingViiV Healthcare.
Transient astrocytic mGluR5 expression drives synaptic plasticity and subsequent chronic pain in mice
Authors: Yosuke Danjo, Eiji Shigetomi, Yukiho J. Hirayama, Kenji Kobayashi, Tatsuya Ishikawa, Yugo Fukazawa, Keisuke Shibata, Kenta Takanashi, Bijay Parajuli, Youichi Shinozaki, Sun Kwang Kim, Junichi Nabekura, Schuichi Koizumi
Journal: The Journal of Experimental Medicine (2022)

Activation of astrocytes has a profound effect on brain plasticity and is critical for the pathophysiology of several neurological disorders including neuropathic pain. Here, we show that metabotropic glutamate receptor 5 (mGluR5), which reemerges in astrocytes in a restricted time frame, is essential for these functions. Although mGluR5 is absent in healthy adult astrocytes, it transiently reemerges in astrocytes of the somatosensory cortex (S1). During a limited spatiotemporal time frame, astrocytic mGluR5 drives Ca2+ signals; upregulates multiple synaptogenic molecules such as Thrombospondin-1, Glypican-4, and Hevin; causes excess excitatory synaptogenesis; and produces persistent alteration of S1 neuronal activity, leading to mechanical allodynia. All of these events were abolished by the astrocyte-specific deletion of mGluR5. Astrocytes dynamically control synaptic plasticity by turning on and off a single molecule, mGluR5, which defines subsequent persistent brain functions, especially under pathological conditions.
Melanoma Epidemiology—Pivoting to Low- and Middle-Income Countries
Authors: Mavis Obeng-Kusi, Ivo Abraham
Journal: JAMA Dermatology (2022)

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“Randomized phase II study of azacitidine ± lenalidomide in higher-risk myelodysplastic syndromes and acute myeloid leukemia with a karyotype including Del(5q)”
Authors: Bengt Rasmussen, Gudrun Göhring, Elsa Bernard, Lars Nilsson, Magnus Tobiasson, Martin Jädersten, Hege Garelius, Ingunn Dybedal, Kirsten Grønbaek, Elisabeth Ejerblad, Fryderyk Lorenz, Max Flogegård, Claus Werenberg Marcher, Annette Öster Fernström, Lucia Cavelier, Elli Papaemmanuil, Freja Ebeling, Astrid Olsnes Kittang, Jan Maxwell Nørgaard, Leonie Saft, Lars Möllgård, Eva Hellström-Lindberg
Journal: Leukemia (2022)
HEART TISSUE IS THE ISSUE: A RARE CASE OF EOSINOPHILIC MYOCARDITIS DUE TO EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS DIAGNOSED ON ENDOMYOCARDIAL BIOPSY
Authors: Simon Pinsky, Alyeesha Wilhelm, Shahzad Ahmad, Heather L. Stevenson, Khaled F. Chatila
Journal: Journal of the American College of Cardiology (2022)
COMPARISONS OF THE PRONE-POSITION AND THE STANDARD 12-LEADS ELECTROCARDIOGRAM: A PROSPECTIVE STUDY IN COVID-19 PATIENTS WITH PULMONARY INVOLVEMENT
Authors: Praew Kotruchin, Krissanachai Chimtim, Pattarapong Makarawate, Piroon Mutsikapun
Journal: Journal of the American College of Cardiology (2022)
Digital biomarkers: Convergence of digital health technologies and biomarkers
Authors: Srikanth Vasudevan, Anindita Saha, Michelle E. Tarver, Bakul Patel
Journal: npj Digital Medicine (2022)

Increasing digitization across the healthcare continuum has revolutionized medical research, diagnostics, and therapeutics. This digitization has led to rapid advancements in the development and adoption of Digital Health Technologies (DHT) by the healthcare ecosystem. With the proliferation of DHTs, the term 'digital biomarker' has been increasingly used to describe a broad array of measurements. Our objectives are to align the meaning of 'digital biomarker' with established biomarker terminology and to highlight opportunities to enable consistency in evidence generation and evaluation, improving the assessment of scientific evidence for future digital biomarkers.
Genetic associations at regulatory phenotypes improve fine-mapping of causal variants for 12 immune-mediated diseases
Authors: Kousik Kundu, Manuel Tardaguila, Alice L. Mann, Stephen Watt, Hannes Ponstingl, Louella Vasquez, Dominique Von Schiller, Nicholas W. Morrell, Oliver Stegle, Tomi Pastinen, Stephen J. Sawcer, Carl A. Anderson, Klaudia Walter, Nicole Soranzo
Journal: Nature Genetics (2022)
META-ANALYSIS OF THE OUTCOMES OF PERCUTANEOUS CORONARY INTERVENTION PRIOR TO TAVR VERSUS TAVR ALONE IN PATIENTS WITH SEVERE AORTIC STENOSIS AND SIGNIFICANT CORONARY ARTERY DISEASE
Authors: Aravdeep Jhand, M. Chadi Alraies, Emmanouil S. Brilakis, Mamas A. Mamas, J Dawn Abbott, Deepak L. Bhatt, Poonam Velagapudi
Journal: Journal of the American College of Cardiology (2022)
CEREBRAL INFARCT, PULMONARY EMBOLISM, OR BOTH? AN INTRICATE CASE REVEALED BY TIMELY UTILIZATION OF TRANSTHORACIC ECHOCARDIOGRAPHY
Authors: Nicole Parellada, Sukhpreet Kaur, Vanessa Hurtado, Ayi B. Eta, Marian Calfa
Journal: Journal of the American College of Cardiology (2022)