tbuckley/cabot-search huggingface dataset:
Abstract 2261: Long-term Survival After Coronary Revascularization With Or Without Mitral Valve Repair In Chronic Ischemic Mitral Regurgitation. A Propensity Analysis.
Authors: Jolanta Biernat, Krzysztof S Golba, Marek A Deja, Wojciech Domaradzki, Kazimierz Widenka, Marek Jasiński, Anna Maria Dalecka, Marcin Malinowski, Tomasz Roleder, Romuald Twardowski, Stanislaw Wos
Journal: Circulation (2007)

Good results are reported after the mitral valve (MV) repair for ischemic mitral regurgitation (MR). The aim of the study was to assess results of the mitral annuloplasty (MVpl) in addition to CABG...
Outcomes of Combination of HLA-Haploidentical Hematopoietic SCT with an Unrelated Cord Blood Unit for 127 Patients with Acquired Severe Aplastic Anemia
Authors: Miao Miao, Limin Liu, Huiying Qiu, XiaoWen Tang, Yue Han, Chengcheng Fu, Zhengming Jin, Aining Sun, Depei Wu
Journal: Blood (2017)
Statin use and risk of severe bacterial infection in a population living with HIV: prospective cohort study of the ANRS CO3 Aquitaine Cohort 2000–2018
Authors: Eva Teruel, Marie-Anne Vandenhende, Didier Neau, Estibaliz Lazaro, Pierre Duffau, Marc-Olivier Vareil, Charles Cazanave, Adélaïde Perrier, Fabien le Marec, Olivier Leleux, Fabrice Bonnet, Linda Wittkop
Journal: Clinical Microbiology and Infection (2020)
14087 Integrating genomics for the diagnosis and prognosis of melanoma into clinical practice
Authors: Graham H. Litchman, Brian Berman, Roger I. Ceilley, Clay J. Cockerell, Laura Ferris, Whitney A. High, Mark Lebwohl, Mark Nestor, Theodore Rosen, Ryan M. Svoboda, Darrell S. Rigel
Journal: Journal of the American Academy of Dermatology (2020)
Effect of a Proposed Modification of the Type 1 and Type 2 Myocardial Infarction Definition on Incidence and Prognosis
Authors: Hadrien Schoepfer, Thomas Nestelberger, Jasper Boeddinghaus, Raphael Twerenbold, Pedro Lopez-Ayala, Luca Koechlin, Desiree Wussler, Tobias Zimmermann, Oscar Miro, Javier F. Martín-Sánchez, Michael Christ, Dagmar I. Keller, Maria Rubini Gimenez, Christian Mueller, Danielle M. Gualandro, Ketina Arslani, Paul David Ratmann, Petra Hillinger, Mario Meier, Tania Coscia, Michael Freese, Joan Elias Walter, Valentina Troester, Noemi Glarner, Christian Puelacher, Patrick Badertscher, Karin Wildi, Eliska Potlukova, Damian Kawecki, Beata Morawiec, Franz Buergler, Nicolas Geigy, Tobias Reichlin
Journal: Circulation (2020)
Factors Associated With the Risk of Progression of Low-Risk Branch-Duct Intraductal Papillary Mucinous Neoplasms
Authors: Gabriele Capurso, Stefano Crippa, Giuseppe Vanella, Mariaemilia Traini, Giulia Zerboni, Piera Zaccari, Giulio Belfiori, Manuel Gentiluomo, Tommaso Pessarelli, Maria Chiara Petrone, Daniele Campa, Massimo Falconi, Paolo Giorgio Arcidiacono
Journal: JAMA Network Open (2020)

<h3>Importance</h3> Branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs) are common pancreatic preneoplastic lesions, but their surveillance is not personalized. <h3>Objective</h3> To investigate patient- and cyst-related factors associated with progression into worrisome features (WFs) or high-risk stigmata (HRS) categories of BD-IPMNs. <h3>Design, Setting, and Participants</h3> Cyst- and patient-related factors of consecutive BD-IPMNs without WFs or HRS in 540 patients diagnosed from 2009 to 2018 with at least 12 months' surveillance until February 28, 2020, were registered in a 2-center ambispective cohort study in Italy. In a subgroup, the ABO blood group was studied for the first time in this setting. <h3>Exposure</h3> Cyst-related and patients-related factors and ABO blood group. <h3>Main Outcomes and Measures</h3> The study outcome was the appearance of WFs or HRS according to the 2017 International Association of Pancreatology guidelines. Survival probability was calculated using Kaplan-Meier curve and risk factors identified by Cox proportional hazards regression. ABO blood group was inferred through genotypes with DNA extraction. <h3>Results</h3> Of 540 patients with BD-IPMNs (median age, 66 years [interquartile range, 58.5-72.0 years]; 337 women [62.4%]) undergoing surveillance for a median of 51.5 months (interquartile range, 28-84 months) for 2758 person-years, 130 patients (24.1%) experienced progression. Probability of progression was 3.7% at 1 year, 23.4% at 5 years, and 43.3% at 10 years; 15 patients (2.8%) underwent surgery, 7 patients (1.3%) had malignant histologic findings, and 3 patients (0.56%) died of pancreatic-associated disease. Initial cyst size greater than 15 mm (hazard ratio [HR], 2.05; 95% CI, 1.44-2.91), body mass index greater than 26.4 (HR, 1.72; 95% CI, 1.19-2.50), and heavy smoking (HR, 1.81; 95% CI, 1.14-2.86) were significant independent factors associated with progression risk. The AA blood genotype was also associated with progression risk (HR, 3.49; 95% CI, 1.04-11.71) compared with the OO genotype in the investigated subgroup. <h3>Conclusions and Relevance</h3> This analysis of factors associated with progression of BD-IPMNs according to recent guidelines suggests that cyst size alone is not a reliable factor for estimation of progression risk; however, along with other readily available data, size is helpful for planning personalized surveillance of BD-IPMNs.
15319 52-week evaluation of the efficacy of dupilumab for moderate to severe atopic dermatitis in clinical practice: A Canadian multicenter retrospective study
Authors: Christine E. Jo, Jorge R. Georgakopoulos, Matthew Ladda, Arvin Ighani, Aaron Drucker, Asfandyar Mufti, Jensen Yeung, Vincent Piguet
Journal: Journal of the American Academy of Dermatology (2020)
Abstract 16484: Intervening With the Nitric Oxide Pathway to Alleviate Pulmonary Hypertension in Pulmonary Vein Stenosis
Authors: Daphne Merkus, Richard W van Duin, Kelly Stam, AH J Danser, Dirk J Duncker
Journal: Circulation (2019)

Introduction: Type 2 Pulmonary hypertension (PH) as a result of pulmonary vein stenosis (PVS) is extremely difficult to treat. The ideal therapy should not target the high pressure/low flow (HP/LF)...
196TiP Perioperative sintilimab in combination with concurrent chemoradiotherapy for patients with locally advanced gastric or gastroesophageal junction (GEJ) adenocarcinoma
Authors: J. Wei, X. Lu, Q. Liu, L. Li, S. Liu, F. Liu, Y. Fu, X. Fan, J. Yang, Y. Yang, Y. Zhao, W. Guan, B. Liu
Journal: Annals of Oncology (2020)
AB0372 PREGNANCY OUTCOME IN WOMEN WITH SJÖGREN SYNDROME IS OFTEN COMPLICATED BY PLACENTA INSUFFICIENCY
Authors: I. Troester, F. Kollert, A. Zbinden, L. Raio, F. Foerger
Journal: Annals of the Rheumatic Diseases (2020)

Background: Chronic inflammatory rheumatic diseases are often associated with a negative effect on pregnancy outcome. Most obstetrical complications are placenta-mediated such as preterm delivery and growths restrictions. In women with Sjögren syndrome, data on placenta- mediated complications are scarce and conflicting (1,2). Objectives: To analyse neonatal outcome in women with Sjögren syndrome with focus on preterm delivery and growth restriction. Methods: We retrospectively analysed 23 pregnancies of 16 patients with Sjögren syndrome that were followed at our centre with regard to pregnancy outcome, medication and disease characteristics. Small for gestational age was defined as birthweight percentile &lt;10 th . Preterm delivery was defined as delivery before 37, early term as delivery between 37-39 and term as delivery between 39-42 weeks of gestation. Results: Of 23 pregnancies, one ended in a miscarriage and 22 resulted in live births including one set of twins. Treatment used during pregnancy was hydroxychloroquine (20 pregnancies), prednisone (8), azathioprine (5) and cyclosporine (2). Concomitant treatment with low-dose aspirin was used in 9 pregnancies. Of the 22 live births, 17 were born at early term and 5 at term. There were no preterm deliveries. Median birth weight was 2820g (range 2095-3845g). Nine newborns (40.9%) were small for gestational age (SGA). Maternal treatment during these pregnancies was hydroxychloroquine in all cases and additional low-dose aspirin in three cases. Elevated CRP levels during pregnancy were found in 57% of the cases with SGA outcome. Only one woman with an SGA infant had positive anti-phospholipid antibodies. Regarding delivery mode, most patients had caesarean sections. Conclusion: In our cohort of women with Sjögren syndrome the prevalence of small for gestational age infants was high despite maternal treatment with hydroxychloroquine. Inflammatory markers could help to identify the patients at risk for placental insufficiency, yet prospective studies of larger cohorts are needed. References: [1]Gupta S et al; Sjögren Syndrome and Pregnancy: A literature review. Perm J 2017; 21:16-047 [2]De Carolis S et al; The impact of primary Sjögren’s syndrome on pregnancy outcome: Our series and review of the literature. Autoimmun Rev 2014; 13(2):103-7 Disclosure of Interests: Isabella Troester: None declared, Florian Kollert Employee of: Novartis, Astrid Zbinden: None declared, Luigi Raio: None declared, Frauke Foerger Grant/research support from: unrestricted grant from UCB, Consultant of: UCB, GSK, Roche, Speakers bureau: UCB, GSK
Re: Marcus J. Drake, Amanda L. Lewis, Grace J. Young, et al. Diagnostic Assessment of Lower Urinary Tract Symptoms in Men Considering Prostate Surgery: A Noninferiority Randomised Controlled Trial of Urodynamics in 26 Hospitals. Eur Urol 2020;78:701–10
Authors: Sachin Malde, Arun Sahai, Eskinder Solomon
Journal: European Urology (2020)
16829 Risk of major cardiovascular events with interleukin-12/23 inhibition compared with tumor necrosis factor α in patients with psoriasis: Pharmacovigilance analysis within a large Midwestern US patient population from the RADAR program
Authors: Nari Lee, Sara Majewski, Yasmeen Ali, Jennifer J. Parker, Shatil Amin, Ahmad Amin, Dennis P. West, Beatrice Nardone
Journal: Journal of the American Academy of Dermatology (2020)
14148 Pharmacokinetics, safety, and efficacy of dupilumab in children aged ≥2 to &lt;6 years with severe uncontrolled atopic dermatitis (LIBERTY AD PRE-SCHOOL)
Authors: Eric L. Simpson, Mohamed Ahmed Kamal, John D. Davis, Xian Sun, Abhijit Gadkari, Laurent Eckert, Ana Beatris Rossi, Ashish Bansal
Journal: Journal of the American Academy of Dermatology (2020)
Abstract 15554: Mechanical Dispersion Differences Among Vendors in Patients With Left Ventricular Hypertrophy
Authors: Yoshihito Saijo, Brett Sperry, Dermot Phelan, Milind Desai, Brian P Griffin, Richard A Grimm, Kimi Sato, Zoran B Popovic
Journal: Circulation (2019)

Introduction: Mechanical dispersion (MD), a measure of heterogeneity of left ventricular (LV) myocardial contraction, is an emerging noninvasive marker of ventricular arrhythmias, and may be releva...
15661 Dermoscopy of localized argyria
Authors: Julian Boix-Vilanova, L.J. del Pozo Hernando, Juan Escalas, Daniel Ramos, Ines Gracia-Darder, Marco Antonio Martínez Ortega, María Concepción Montis Palos, Ana Bauza, Noelia Izquierdo Herce, Carles Saus, Ana Martin-Santiago
Journal: Journal of the American Academy of Dermatology (2020)
387P Phase Ib study of savolitinib ± osimertinib in Japanese patients (pts) with advanced solid malignancies &amp; EGFRm NSCLC: TATTON part C
Authors: T. Hirashima, K. Yoh, H. Saka, T. Kurata, Y. Ohe, T. Hida, A. Mellemgaard, R.B. Verheijen, X. Ou, M. Hayama, K. Sugibayashi, G. Oxnard
Journal: Annals of Oncology (2020)
Nanotools for Sepsis Diagnosis and Treatment
Authors: Lana Papafilippou, Andrew Claxton, Paul Dark, Kostas Kostarelos, Marilena Hadjidemetriou
Journal: Advanced Healthcare Materials (2020)

Abstract Sepsis is one of the leading causes of death worldwide with high mortality rates and a pathological complexity hindering early and accurate diagnosis. Today, laboratory culture tests are the epitome of pathogen recognition in sepsis. However, their consistency remains an issue of controversy with false negative results often observed. Clinically used blood markers, C reactive protein (CRP) and procalcitonin (PCT) are indicators of an acute‐phase response and thus lack specificity, offering limited diagnostic efficacy. In addition to poor diagnosis, inefficient drug delivery and the increasing prevalence of antibiotic‐resistant microorganisms constitute significant barriers in antibiotic stewardship and impede effective therapy. These challenges have prompted the exploration for alternative strategies that pursue accurate diagnosis and effective treatment. Nanomaterials are examined for both diagnostic and therapeutic purposes in sepsis. The nanoparticle (NP)‐enabled capture of sepsis causative agents and/or sepsis biomarkers in biofluids can revolutionize sepsis diagnosis. From the therapeutic point of view, currently existing nanoscale drug delivery systems have proven to be excellent allies in targeted therapy, while many other nanotherapeutic applications are envisioned. Herein, the most relevant applications of nanomedicine for the diagnosis, prognosis, and treatment of sepsis is reviewed, providing a critical assessment of their potentiality for clinical translation.
Treating Coronary Artery Disease: Beyond Statins, Ezetimibe, and PCSK9 Inhibition
Authors: Kiran Musunuru
Journal: Annual Review of Medicine (2020)

Statins, ezetimibe, and PCSK9 inhibitors are currently the standard of care for the prevention and treatment of coronary artery disease. Despite their widespread use, coronary artery disease remains the leading cause of death worldwide, a fact that pleads for the development of new protective therapies. In no small part due to advances in the field of human genetics, many new therapies targeting various lipid traits or inflammation have recently received approval from regulatory agencies such as the US Food and Drug Administration or fared favorably in clinical trials. This wave of new therapies promises to transform the care of patients at risk for life-threatening coronary events.
Comparative bench study evaluation of a modified snorkeling mask used during COVID-19 pandemic and standard interfaces for non-invasive ventilation
Authors: G. Ferrone, G. Spinazzola, R. Costa, A. Gullì, A. Scapigliati, M. Antonelli, G. Conti
Journal: Pulmonology (2021)

The aim of this bench study is to compare the standard NIV and nCPAP devices (Helmet, H; Full face mask, FFM) with a modified full face snorkeling mask used during COVID-19 pandemic.A mannequin was connected to an active lung simulator. The inspiratory and expiratory variations in airways pressure observed with a high simulated effort, were determined relative to the preset CPAP level. NIV was applied in Pressure Support Mode at two simulated respiratory rates and two cycling-off flow thresholds. During the bench study, we measured the variables defining patient-ventilator interaction and performance.During nCPAP, the tested interfaces did not show significant differences in terms of ∆Pawi and ∆Pawe. During NIV, the snorkeling mask demonstrated a better patient-ventilator interaction compared to FFM, as shown by significantly shorter Pressurization Time and Expiratory Trigger Delay (p < 0.01), but no significant differences were found in terms of Inspiratory Trigger Delay and Time of Synchrony between the interfaces tested. At RR 20sim, the snorkeling mask presented the lower ΔPtrigger (p < 0.01), moreover during all the conditions tested the snorkeling mask showed the longer Pressure Time Product at 200, 300, and 500 ms compared to FFM (p < 0.01). A major limitation of snorkeling mask is that during NIV with this interface it is possible to reach maximum 18 cmH2O of peak inspiratory pressure.The modified snorkeling mask can be used as an acceptable alternative to other interfaces for both nCPAP and NIV in emergencies.
Dyspnoea from a rapidly growing intrathoracic mass
Authors: Ria Itty, Hau Chieng, Ammoura Ibrahim, John P Nabagiez, John Fantauzzi, Amit Chopra
Journal: Thorax (2020)

A 54-year-old man presented with progressive dyspnoea and non-productive cough for 2 months. A physical examination revealed diminished breath sounds and dullness to percussion on the right side. A preoperative chest radiograph for elective left knee arthroplasty 2 months prior to this presentation showed a 16 mm nodule in the right middle lung field (figure 1A).



Figure 1 
(A) Chest radiograph showing a 16 mm right-sided lung nodule in the mid-lung field (red arrow). (B) Chest CTPA revealing a 4.5 cm solid, homogeneous, pleural-based mass with clear borders forming an obtuse angle with the chest wall. (C) Chest radiograph 2 months after the initial CT chest showing significant progression of the mass. (D) PET-CT chest demonstrating hypermetabolic uptake of the fluorodeoxyglucose of the large right pleural base mass. CTPA, CT pulmonary angiogram; PET-CT, positron emission tomography-CT.



A CT pulmonary angiogram obtained 1 month after left knee arthroplasty for the complaint of dyspnoea did not reveal pulmonary embolism, however, a well-circumscribed, homogeneous 5.2 cm pleural-based mass was found in right lower haemithorax (figure 1B). A core-needle …
Improved Risk Assessment for Abdominal Aortic Aneurysm Rupture: Off-the-Wall Imaging⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Authors: Thomas A. Hope, Michael D. Hope
Journal: Journal of the American College of Cardiology (2011)
A Phase 2, International, Multicenter, Prospective Clinical Trial of Subcutaneous Tbo-Filgrastim in Pediatric Patients with Solid Tumors Undergoing Chemotherapy
Authors: Noah Federman, Monica Desiree Dragomir, Zoryana Kizyma, Vladimir Lebedev, Jelena Roganovic, Peter Bias, Andreas Lammerich, Zipi Roth-Ben Arie, Linglong Zou, Anton Buchner
Journal: Blood (2017)
13838 Benefits of apremilast treatment in patients with plaque psoriasis, including scalp and nail manifestations, in patients who failed to achieve adequate response or were intolerant to methotrexate treatment
Authors: Kristian Reich, Stefanie Fritzlar, Bernhard Korge, Uwe Schwichtenberg, Stephan Morys, Katrin Lorenz-Baath, Josefine Roemmler-Zehrer, Natalie Núnez Gómez
Journal: Journal of the American Academy of Dermatology (2020)
Doctors welcome report’s call for universities to tackle racism
Authors: Abi Rimmer
Journal: BMJ (2020)

The BMA has welcomed a report offering practical guidance to UK universities on tackling racial harassment.

The report by Universities UK,1 which represents 140 universities, said that medical placements had been identified by the Equality and Human Rights Commission as “a common situation when students may experience racial harassment.”

Universities should review their procedures for handling racial harassment complaints, define clear channels for reporting incidents of racial harassment, and systematically collect data on reports of racial harassment, …
Abstract 15027: Infliximab Decreases FDG Uptake on Cardiac PET in Refractory Cardiac Sarcoidosis
Authors: N Gurukripa Kowlgi, Robert Meredith, Huzaefah Syed, Aamer Syed, Thomas Iden, Kenneth Ellenbogen, Jordana Kron
Journal: Circulation (2017)

Introduction: Cardiac sarcoidosis (CS) is characterized by granulomatous inflammation and fibrosis that may cause heart block, ventricular arrhythmias or heart failure. Corticosteroids are the main...
LAD冠状動脈直径の新規,小型トランスデューサを用いる経胸腔内心エコー検査法による評価:定量的冠状動脈血管造影法との比較
Authors: Hirano K, Nakao S, Goda A, Yoshida Y, Yuba M, Ohyanagi M, Iwasaki T
Journal: Circulation (2003)
Hydroxyurea does not affect the spermatogonial pool in prepubertal patients with sickle cell disease
Authors: Anne-Sophie Gille, Corinne Pondarré, Jean-Hugues Dalle, Françoise Bernaudin, Céline Chalas, Mony Fahd, Camille Jean, Harry Lezeau, Lydia Riou, Véronique Drouineaud, Annabel Paye-Jaouen, Annie Kamdem, Bénédicte Neven, Cécile Arnaud, Saba Azarnoush, Karima Yakouben, Sabine Sarnacki, Mariane de Montalembert, Eva Maria Comperat, Gilles Lenaour, Mathilde Sibony, Nathalie Dhédin, Daniel Vaiman, Jean-Philippe Wolf, Catherine Patrat, Pierre Fouchet, Catherine Poirot, Virginie Barraud-Lange
Journal: Blood (2020)
Cases in Precision Medicine: The Role of Polygenic Risk Scores in Breast Cancer Risk Assessment
Authors: Nur Zeinomar, Wendy K. Chung
Journal: Annals of Internal Medicine (2020)

Polygenic risk scores (PRSs) have been consistently associated with elevated breast cancer risk in cohort studies and are associated with risk in both women with and those without a family history of breast cancer. However, before clinical implementation, several issues must be addressed, including understanding the potential clinical utility and optimal method to communicate personalized screening recommendations that incorporate the PRS. Several trials are under way to answer some of these questions and facilitate clinical implementation. Because these PRSs have been developed in women of European ancestry, it is important to understand the limitations of their predictive ability in other ancestral groups. Finally, the value of the PRS will lie in considering it along with other clinical, familial, and rare genetic factors that are currently used in personalized risk assessment of breast cancer.
15433 Assessment of cytochrome P450 3A inhibition and induction of abrocitinib: Midazolam drug-drug interaction (DDI) study and oral contraceptive DDI study
Authors: Xiaoxing Wang, Yeamin Huh, Madelyn Curto, Gary Chan, Martin E. Dowty, Melissa O'Gorman, Sakambari Tripathy, Bimal Malhotra, Pankaj Gupta
Journal: Journal of the American Academy of Dermatology (2020)
Targeting the Four Pillars of Enterohepatic Bile Salt Cycling; Lessons From Genetics and Pharmacology
Authors: Roni F. Kunst, Henkjan J. Verkade, Ronald P.J. Oude Elferink, Stan F.J. van de Graaf
Journal: Hepatology (2020)

Bile salts play a pivotal role in lipid homeostasis, are sensed by specialized receptors, and have been implicated in various disorders affecting the gut or liver. They may play a role either as culprit or as potential panacea. Four very efficient transporters mediate most of the hepatic and intestinal bile salt uptake and efflux, and are each essential for the efficient enterohepatic circulation of bile salts. Starting from the intestinal lumen, conjugated bile salts cross the otherwise impermeable lipid bilayer of (primarily terminal ileal) enterocytes through the apical sodium-dependent bile acid transporter (gene SLC10A2) and leave the enterocyte through the basolateral heteromeric organic solute transporter, which consists of an alpha and beta subunit (encoded by SLC51A and SLC51B). The Na+ -taurocholate cotransporting polypeptide (gene SLC10A1) efficiently clears the portal circulation of bile salts, and the apical bile salt export pump (gene ABCB11) pumps the bile salts out of the hepatocyte into primary bile, against a very steep concentration gradient. Recently, individuals lacking either functional Na+ -taurocholate cotransporting polypeptide or organic solute transporter have been described, completing the quartet of bile acid transport deficiencies, as apical sodium-dependent bile acid transporter and bile salt export pump deficiencies were already known for years. Novel pathophysiological insights have been obtained from knockout mice lacking functional expression of these genes and from pharmacological transporter inhibition in mice or humans. Conclusion: We provide a concise overview of the four main bile salt transport pathways and of their status as possible targets of interventions in cholestatic or metabolic disorders.