tbuckley/cabot-search huggingface dataset:
Epitope convergence of broadly HIV-1 neutralizing IgA and IgG antibody lineages in a viremic controller
Authors: Valérie Lorin, Ignacio Fernández, Guillemette Masse-Ranson, Mélanie Bouvin-Pley, Luis M. Molinos-Albert, Cyril Planchais, Thierry Hieu, Gérard Péhau-Arnaudet, Dominik Hrebík, Giulia Girelli-Zubani, Oriane Fiquet, Florence Guivel-Benhassine, Rogier W. Sanders, Bruce D. Walker, Olivier Schwartz, Johannes F. Scheid, Jordan D. Dimitrov, Pavel Plevka, Martine Braibant, Michael S. Seaman, François Bontems, James P. Di Santo, Félix A. Rey, Hugo Mouquet
Journal: The Journal of Experimental Medicine (2022)

Decrypting the B cell ontogeny of HIV-1 broadly neutralizing antibodies (bNAbs) is paramount for vaccine design. Here, we characterized IgA and IgG bNAbs of three distinct B cell lineages in a viremic controller, two of which comprised only IgG+ or IgA+ blood memory B cells; the third combined both IgG and IgA clonal variants. 7-269 bNAb in the IgA-only lineage displayed the highest neutralizing capacity despite limited somatic mutation, and delayed viral rebound in humanized mice. bNAbs in all three lineages targeted the N332 glycan supersite. The 2.8-Å resolution cryo-EM structure of 7-269-BG505 SOSIP.664 complex showed a similar pose as 2G12, on an epitope mainly composed of sugar residues comprising the N332 and N295 glycans. Binding and cryo-EM structural analyses showed that antibodies from the two other lineages interact mostly with glycans N332 and N386. Hence, multiple B cell lineages of IgG and IgA bNAbs focused on a unique HIV-1 site of vulnerability can codevelop in HIV-1 viremic controllers.
Serum Diagnosis of Syphilis and Luetin Reaction.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Allergic Contact Dermatitis
Authors: Brandon L. Adler, Vincent A. DeLeo
Journal: JAMA Dermatology (2021)

Allergic Contact DermatitisAllergic contact dermatitis (ACD) is a rash caused by an immune reaction to various substances that touch the skin.Allergic contact dermatitis is common, occurring in up to 1 in 5 people.Although anyone can be affected at any age, people with eczema since childhood may be more likely to develop ACD. Signs and SymptomsAfter becoming allergic to a substance, further contact causes itchy, red, and flaky rashes, sometimes with blisters or oozing.Rashes are delayed, usually taking hours or days to appear and weeks to heal.They are most intense at areas of direct skin contact, but may spread.The shape of the rash might hint at its cause, such as streaks from brushing against leaves, or a round patch next to jean snaps.Indirect exposures (eg, substances transferred from one body part to another or carried in the air) can also be involved, causing more widespread reactions.Allergic contact dermatitis can be mildly annoying or severely affect daily life and even the ability to work.Allergic contact dermatitis is complicated by common misconceptions.New and old products can be responsible, and allergy can develop after using the same product for years.Also, ingredients may be changed by manufacturers over time.The responsible product, contacted as little as once weekly, can cause a constant rash.Additionally, allergy can develop to expensive and natural/ organic products.Finally, switching products often does not clear the rash, because similar ingredients may be contained in multiple products.
Balancing Risk and Efficiency in Drug Development for Rare and Challenging Tumors: A New Paradigm for Glioma
Authors: Ingo K. Mellinghoff, Timothy F. Cloughesy
Journal: Journal of Clinical Oncology (2022)

The process of developing cancer therapies is well established and has enabled the incorporation of many new drugs and classes of agents into the standard of care for common cancers. Clinical drug development is fundamentally different for rare and difficult-to-treat solid tumors, such as glioma or pancreatic cancer. The failure to develop effective new agents for the latter diseases has discouraged the development of therapeutics for these cancers. Using glioma as an example, we describe a process toward obtaining more reliable early-stage signals of drug activity and a process toward translating those signals into clinical benefits with more efficient late-stage development. If linked together, these processes should increase the likelihood of benefit in late-stage settings at a lower cost and encourage more drug development for patients with rare and difficult-to-treat cancers.
RBBP4-p300 axis modulates expression of genes essential for cell survival and is a potential target for therapy in glioblastoma
Authors: Ann C Mladek, Huihuang Yan, Shulan Tian, Paul A Decker, Danielle M Burgenske, Katrina Bakken, Zeng Hu, Lihong He, Margaret A Connors, Brett L Carlson, Jonathan Wilson, Archana Bommi-Reddy, Andy Conery, Jeanette E Eckel-Passow, Jann N Sarkaria, Gaspar J Kitange
Journal: Neuro-Oncology (2022)

Abstract Background RBBP4 activates transcription by histone acetylation, but the partner histone acetyltransferases are unknown. Thus, we investigated the hypothesis that RBBP4 interacts with p300 in a complex in glioblastoma (GBM). Methods shRNA silencing of RBBP4 or p300 and RNAseq was used to identify genes co-regulated by RBBP4 and p300 in GBM43 patient-derived xenograft (PDX). RBBP4/p300 complex was demonstrated using proximity ligation assay (PLA) and ChIPseq delineated histone H3 acetylation and RBBP4/p300 complex binding in promoters/enhancers. Temozolomide (TMZ)-induced DNA double strand breaks (DSBs) were evaluated by γ-H2AX and proliferation by CyQuant and live cell monitoring assays. In vivo efficacy was based on survival of mice with orthotopic tumors. Results shRBBP4 and shp300 downregulated 4768 genes among which 1485 (31%) were commonly downregulated by both shRNAs, while upregulated genes were 2484, including 863 (35%) common genes. The pro-survival genes were the top-ranked among the downregulated genes, including C-MYC. RBBP4/p300 complex was demonstrated in the nucleus, and shRBBP4 or shp300 significantly sensitized GBM cells to TMZ compared to the control shNT in vitro (P &amp;lt; .05). Moreover, TMZ significantly prolonged the survival of mice bearing GBM22-shRBBP4 orthotopic tumors compared with control shNT tumors (median shNT survival 52 days vs. median shRBBP4 319 days; P = .001). CREB-binding protein (CBP)/p300 inhibitor CPI-1612 suppressed H3K27Ac and RBBP4/p300 complex target proteins, including C-MYC, and synergistically sensitized TMZ in vitro. Pharmacodynamic evaluation confirmed brain penetration by CPI-1612 supporting further investigation to evaluate efficacy to sensitize TMZ. Conclusions RBBP4/p300 complex is present in GBM cells and is a potential therapeutic target.
Gliptin-associated bullous pemphigoid shows peculiar features of anti-BP180 and -BP230 humoral response: Results of a multicenter study
Authors: Adele Salemme, Luca Fania, Alessandra Scarabello, Marzia Caproni, Angelo Valerio Marzano, Emanuele Cozzani, Claudio Feliciani, Clara De Simone, Manuela Papini, Rosanna Rita Satta, Aurora Parodi, Feliciana Mariotti, Stefania Lechiancole, Giovanni Genovese, Francesca Passarelli, Francesca Festa, Barbara Bellei, Alessia Provini, Donatella Sordi, Sabatino Pallotta, Damiano Abeni, Cinzia Mazzanti, Biagio Didona, Giovanni Di Zenzo
Journal: Journal of the American Academy of Dermatology (2022)
H influenzae vaccines gain favor
Authors: C. Marwick
Journal: JAMA (1990)

IN THE RACE to get a vaccine against<i>Haemophilus influenzae</i>type b that will protect the very youngest infants, two leading candidates have emerged. Although they are made by different manufacturers and have significantly different characteristics, they appear to complement each other. One vaccine raises antibody levels almost immediately after the first injection at 2 months of age; the second takes longer to induce protective antibody levels but, once having reached a protective level, stays there for at least 2 years in more than 80% of subjects. After hearing the reports of studies showing the efficacy and immunogenicity of these vaccines in preventing disease in infants younger than 6 months, presented at a Food and Drug Administration (FDA) committee meeting, Floyd Denny, MD, University of North Carolina School of Medicine, Chapel Hill, chair of the Vaccine and Related Biological Products Advisory Committee, said it appears that the ideal way to
RICKETS.
Journal: JAMA (1892)

The bane of children artificially fed is malnutrition. Most of the malnutrition of infancy takes the form of rickets. While we are not yet in position to speak authoritatively upon the effect of infantile rickets upon the future adult, we are ready to admit that it probably has some effect, most likely in increasing the individual's tendency to disease, diminishing his resisting power, with possibly playing a powerful<i>rôle</i>in putting him into the great class of defectives. The importance, therefore, of detecting the first signs of rickets is apparent. It is too late to be of the best service to make the diagnosis of rickets when advanced bony changes are present Anybody can make the diagnosis of rickets when the head is squared, the ribs compressed, the abdomen distended, the wrists and ankles broadened, and the long bones bent. So can anybody passing in the train of a tornado
Booknotes
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Kinins and Endothelial Control of Vascular Smooth Muscle
Authors: J.-V. Mombouli
Journal: The Annual Review of Pharmacology and Toxicology (1995)

Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive HO-1 isoenzyme affords protection against programmed cell death. The mechanism ...Read More
Chalones and cancer
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Remarks on Modified Linear Extraction
Authors: A. Von Graefe
Journal: BMJ (1867)

i) TT' <IflT A ,+IJTI lT( T ,-"." 0, A,ry.all i;F ~13~L'JPJJI1~LI~JJJ JJtL±N IV4N ~Wi this most fori u '6alth acdes which may accompaniy a :ctamiatcperation, I became Jhte4ante thvo)u~A y *fAteemO6j * TPBIOFESS-OR -A.VOK_ff ('IUPE-A yow'iipVc BERLi*.'~~~~~~'s_1 U1,0 it sOix-tme We s4v ima4tor -flp.extrLc-H~~~,.~tio%tAMid-onde after =odifieo extraAi t1on--'on- VILL-ESOAPE OF VITitEOtf~~~~~~~f our-were obviously diseasedṽ i.,wo,aretedw~fth WAIIAT aong the first hundr-ed of ity,q ratibots I ,;A 4hj'1 degeofcicdt stjr,oeeio4l had'tliirteen times esc,%pe o~vteu uour, in! ttete'for eqwprR qii9p,a~oesifrn the lAklhunded t~aeideit ~i~di~dysix from chronic-glaucoma; the~fifhyeai,blnd times.Thus, the perc~~~~~~entage is no lon n 41
Elective upper-neck versus whole-neck irradiation of the uninvolved neck in patients with nasopharyngeal carcinoma: an open-label, non-inferiority, multicentre, randomised phase 3 trial
Authors: Ling-Long Tang, Cheng-Long Huang, Ning Zhang, Wei Jiang, Yi-Shan Wu, Shao Hui Huang, Yan-Ping Mao, Qing Liu, Ji-Bin Li, Shao-Qiang Liang, Guan-Jie Qin, Wei-Han Hu, Ying Sun, Fang-Yun Xie, Lei Chen, Guan-Qun Zhou, Jun Ma
Journal: The Lancet Oncology (2022)
Questions and Answers
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recent historic increase of infant mortality in France: A time-series analysis, 2001 to 2019
Authors: Nhung T.H. Trinh, Sophie de Visme, Jérémie F. Cohen, Tim Bruckner, Nathalie Lelong, Pauline Adnot, Jean-Christophe Rozé, Béatrice Blondel, François Goffinet, Grégoire Rey, Pierre-Yves Ancel, Jennifer Zeitlin, Martin Chalumeau
Journal: The Lancet Regional Health - Europe (2022)

The infant mortality rate (IMR) serves as a key indicator of population health.We used data from the French National Institute of Statistics and Economic Studies on births and deaths during the first year of life from 2001 to 2019 to calculate IMR aggregated by month. We ran joinpoint regressions to identify inflection points and assess the linear trend of each segment. Exploratory analyses were performed for overall IMR, as well as by age at death subgroups (early neonatal [D0-D6], late neonatal [D7-27], and post-neonatal [D28-364]), and by sex. We performed sensitivity analyses by excluding deaths at D0 and using other time-series modeling strategies.Over the 19-year study period, 53,077 infant deaths occurred, for an average IMR of 3·63/1000 (4·00 in male, 3·25 in female); 24·4% of these deaths occurred during the first day of life and 47·8% during the early neonatal period. Joinpoint analysis identified two inflection points in 2005 and 2012. The IMR decreased sharply from 2001 to 2005 (slope: -0·0167 deaths/1000 live births/month; 95%CI: -0·0219 to -0·0116) and then decreased slowly between 2005 and 2012 (slope: -0·0041; 95%CI: -0·0065 to -0·0016). From 2012 onwards, a significant increase in IMR was observed (slope: 0·0033; 95%CI: 0·0011 to 0·0056). Subgroup analyses indicated that these trends were driven notably by an increase in the early neonatal period. Sensitivity analyses provided consistent results.The recent historic increase in IMR since 2012 in France should prompt urgent in-depth investigation to understand the causes and prepare corrective actions.No financial relationships with any organizations that might have an interest in the submitted work in the previous three years, no other relationships or activities that could appear to have influenced the submitted work.
Medical News
Journal: JAMA (1918)

(Physicians will confer a favor by sending for this department items of news of more or less general interest; such as relate to society activities, new hospitals, education, public health, etc.) <h3>DISTRICT OF COLUMBIA</h3><h3>Inroads of the War on School Medical Inspection Staff.</h3> -Soon after the entrance of the United States into the war, Dr. Prentiss Willson and Dr. Albert Ridgely, medical inspectors of schools, entered the Army Medical Service. During the past summer, Dr. John Thomas was commissioned and sent to camp, and during the past few weeks Dr. Joseph A. Murphy, chief medical and sanitary inspector of schools, was ordered to Camp Jackson, S. C., and Dr. H. C. Macatee, to duty at U. S. Naval Dispensary, Washington, D. C. <h3>Curtailment of Medical Society Activities.</h3> —The Medical Society of the District of Columbia has long prided itself on maintaining meetings every week from October to May, always with
Increased 30-day mortality in very old ICU patients with COVID-19 compared to patients with respiratory failure without COVID-19
Authors: Bertrand Guidet, Christian Jung, Hans Flaatten, Jesper Fjølner, Antonio Artigas, Bernardo Bollen Pinto, Joerg C. Schefold, Michael Beil, Sviri Sigal, Peter Vernon van Heerden, Wojciech Szczeklik, Michael Joannidis, Sandra Oeyen, Eumorfia Kondili, Brian Marsh, Finn H. Andersen, Rui Moreno, Maurizio Cecconi, Susannah Leaver, Dylan W. De Lange, Ariane Boumendil, Philipp Eller, Michael Joannidis, Dieter Mesotten, Pascal Reper, Sandra Oeyen, Walter Swinnen, Helene Brix, Jens Brushoej, Maja Villefrance, Helene Korvenius Nedergaard, Anders Thais Bjerregaard, Ida Riise Balleby, Kasper Andersen, Maria Aagaard Hansen, Stine Uhrenholt, Helle Bundgaard, Jesper Fjølner, Aliae A. R. Mohamed Hussein, Rehab Salah, Yasmin Khairy Nasr Eldin Mohamed Ali, Kyrillos Wassim, Yumna A Elgazzar, Samar Tharwat, Ahmed Y. Azzam, Ayman Abdelmawgoad Habib, Hazem Maarouf Abosheaishaa, Mohammed A. Azab, Susannah Leaver, Arnaud Galbois, Tomas Urbina, Cyril Charron, Emmanuel Guerot, Guillaume Besch, Jean-Philippe Rigaud, Julien Maizel, Michel Djibré, Philippe Burtin, Pierre Garcon, Saad Nseir, Xavier Valette, Nica Alexandru, Nathalie Marin, Marie Vaissiere, Gaëtan Plantefeve, Thierry Vanderlinden, Igor Jurcisin, Buno Megarbane, Anais Caillard, Arnaud Valent, Marc Garnier, Sebastien Besset, Johanna Oziel, Jean-herlé Raphalen, Stéphane Dauger, Guillaume Dumas, Bruno Goncalves, Gaël Piton, Eberhard Barth, Ulrich Goebel, Eberhard Barth, Anselm Kunstein, Michael Schuster, Martin Welte, Matthias Lutz, Patrick Meybohm, Stephan Steiner, Tudor Poerner, Hendrik Haake, Stefan Schaller, Stefan Schaller, Stefan Schaller, Detlef Kindgen-Milles, Christian Meyer, Muhammed Kurt, Karl Friedrich Kuhn, Winfried Randerath, Jakob Wollborn, Zouhir Dindane, Hans-Joachim Kabitz, Ingo Voigt, Gonxhe Shala, Andreas Faltlhauser, Nikoletta Rovina, Zoi Aidoni, Evangelia Chrisanthopoulou, Antonios Papadogoulas, Mohan Gurjar, Ata Mahmoodpoor, Abdullah Khudhur Ahmed, Brian Marsh, Ahmed Elsaka, Sigal Sviri, Vittoria Comellini, Ahmed Rabha, Hazem Ahmed, Silvio A. Namendys-Silva, Abdelilah Ghannam, Martijn Groenendijk, Marieke Zegers, Dylan de Lange, Alexander Daniel Cornet, Mirjam Evers, Lenneke Haas, Tom Dormans, Willem Dieperink, Luis Romundstad, Britt Sjøbø, Finn H. Andersen, Hans Frank Strietzel, Theresa Olasveengen, Michael Hahn, Miroslaw Czuczwar, Ryszard Gawda, Jakub Klimkiewicz, Maria de Lurdes Campos Santos, André Gordinho, Henrique Santos, Rui Assis, Ana Isabel Pinho Oliveira, Mohamed Raafat Badawy, David Perez-Torres, Gemma Gomà, Mercedes Ibarz Villamayor, Angela Prado Mira, Patricia Jimeno Cubero, Susana Arias Rivera, Teresa Tomasa, David Iglesias, Eric Mayor Vázquez, Cesar Aldecoa, Aida Fernández Ferreira, Begoña Zalba-Etayo, Isabel Canas-Perez, Luis Tamayo-Lomas, Cristina Diaz-Rodriguez, Susana Sancho, Jesús Priego, Enas M. Y. Abualqumboz, Momin Majed Yousuf Hilles, Mahmoud Saleh, Nawfel Ben-Hamouda, Andrea Roberti, Alexander Dullenkopf, Yvan Fleury, Bernardo Bollen Pinto, Joerg C. Schefold, Mohammed Al-Sadaw
Journal: Intensive Care Medicine (2022)
Cerebral Ventricular Enlargement
Authors: Jacob H. Fox
Journal: JAMA (1976)

Computerized tomography was used to measure cerebral ventricular size in hospitalized alcoholic patients, all of whom had evidence of liver disease. Twelve alcoholic patients with neurologic symptoms such as withdrawal seizures, neuropathy, and drug overdose were included. All these patients had normal results from the mental status examinations by the time of discharge. Alcoholic patients had a much higher mean ventricular size compared to 60 control patients. One third of the alcoholics had markedly enlarged ventricles as opposed to only one of the 60 controls. (<i>JAMA</i>236:365-368, 1976)