tbuckley/cabot-search huggingface dataset:
In Search of a More Accurate Nodal Staging System for Melanoma
Authors: Kirsten Baecher, Keith Delman, Michael Lowe
Journal: JAMA Surgery (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Environmental toxicant-induced maladaptive mitochondrial changes: A potential unifying mechanism in fatty liver disease?
Authors: Regina D. Schnegelberger, Anna L. Lang, Gavin E. Arteel, Juliane I. Beier
Journal: Acta Pharmaceutica Sinica B (2021)

Occupational and environmental exposures to industrial chemicals are well known to cause hepatotoxicity and liver injury. However, despite extensive evidence showing that exposure can lead to disease, current research approaches and regulatory policies fail to address the possibility that subtle changes caused by low level exposure to chemicals may also enhance preexisting conditions. In recent years, the conceptual understanding of the contribution of environmental chemicals to liver disease has progressed significantly. Mitochondria are often target of toxicity of environmental toxicants resulting in multisystem disorders involving different cells, tissues, and organs. Here, we review persistent maladaptive changes to mitochondria in response to environmental toxicant exposure as a mechanism of hepatotoxicity. With better understanding of the mechanism(s) and risk factors that mediate the initiation and progression of toxicant-induced liver disease, rational targeted therapy can be developed to better predict risk, as well as to treat or prevent this disease.
Letter to the editor: More data on vaccine efficacy/effectiveness of COVID-19 vaccines against asymptomatic SARS-CoV-2 infection
Authors: Ying-Wen Chen, Wen-Chien Ko
Journal: Eurosurveillance (2021)

Preview this article: Letter to the editor: More data on vaccine efficacy/effectiveness of COVID-19 vaccines against asymptomatic SARS-CoV-2 infection, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/26/35/eurosurv-26-35-4-1.gif
Non-invasive lung cancer diagnosis and prognosis based on multi-analyte liquid biopsy
Authors: Kezhong Chen, Jianlong Sun, Heng Zhao, Ruijingfang Jiang, Jianchao Zheng, Zhilong Li, Jiaxi Peng, Haifeng Shen, Kai Zhang, Jin Zhao, Shida Zhu, Yuying Wang, Fan Yang, Jun Wang
Journal: Molecular Cancer (2021)

Chest LDCT provides an effective approach for lung cancer screening, yet has been found to generate a large number of false positives during practice due to excessive diagnosis of pulmonary lesions of indeterminate clinical significance. In this study, we performed comprehensive genetic and epigenetic profiling of cfDNA from lung cancer patients and individuals bearing benign lung lesions, using ultra-deep targeted sequencing and targeted bisulfite sequencing. We found that cfDNA mutation profile alone has relatively limited power in distinguishing malignant from benign plasma, while cfDNA methylation profiling showed a better performance for classification of the two groups and combination of genetic and epigenetic features of cfDNA along with serum protein marker further improved the classification accuracy. We also identified novel methylation-based prognostic markers and showed that an integrated model that combined cfDNA mutational status and methylation-based prognostic markers improved prediction for lung cancer survival. Our results highlight the potential of the multi-analyte assay for non-invasive lung cancer diagnosis and prognosis.
Abstract 1929: Mutations in the Cardiac L-Type Calcium Channel Associated With Four Sudden Cardiac Death Syndromes
Authors: Elena Burashnikov, Ryan Pfeiffer, Martin Borggrefe, Michael Eldar, Michael Glikson, Michel Haissaguerre, Ronald Kanter, Ruben Laino, Mark Marieb, Koonlawee Nadmanee, Gi-Byong Nam, Roberto Robles, Rainer Schimpf, Dwight Stapleton, Sami Viskin, Stephen Winters, Christian Wolpert, Samuel Zimmern, Charles Antzelevitch
Journal: Circulation (2009)

Mutations in the Cardiac L-Type Calcium Channel Associated with Inherited Sudden Cardiac Death Syndromes Background: L-Type Calcium Channel (LTCC) mutations have been associated with Timothy (LQT8)...
Changes in Latina Women’s Exposure to Cleaning Chemicals Associated with Switching from Conventional to “Green” Household Cleaning Products: The LUCIR Intervention Study
Authors: Kim G. Harley, Lucia Calderon, James E.S. Nolan, Randy Maddalena, Marion Russell, Katherine Roman, Stephanie Mayo-Burgos, Jessica Cabrera, Norma Morga, Asa Bradman
Journal: Environmental Health Perspectives (2021)

Household cleaning products may be a significant source of chemical exposures, including carcinogens and suspected endocrine disruptors.We characterized exposures during routine household cleaning and tested an intervention to reduce exposures to cleaning product chemicals.The Lifting Up Communities with Interventions and Research (LUCIR) Study is a youth-led, community-based intervention project. Youth researchers conducted personal air monitoring with 50 Latina women while they cleaned their homes with their regular cleaning products (preintervention visit) and then 1 week later while they used "green" cleaning products provided by the study (postintervention visit). Air samples were analyzed for volatile and semivolatile organic compounds using gas chromatography-mass spectrometry and high-performance liquid chromatography. We compared pre- and postintervention air concentrations of 47 chemicals of concern, selected because they were on California's Proposition 65 list of carcinogens or reproductive/developmental toxicants or were suspected endocrine disruptors. Youth researchers were integrally involved in the study design, data collection, interpretation, and dissemination of findings.We observed statistically significant decreases in air concentrations of 17 chemicals of concern when participants switched to green cleaning products, including decreases in geometric mean concentrations of 1,4-dioxane (-46.4%), chloroform (-86.7%), benzene (-24.8%), naphthalene (-40.3%), toluene (-24.2%), and hexane (-35.5%). We observed significant increases in air concentrations of three fragrance compounds: the plant-derived terpene, beta-myrcene (221.5%), and the synthetic musks celestolide (31.0%) and galaxolide (79.6%). Almost all participants (98%) said the replacement products worked as well as their original products, and 90% said that they would consider buying the replacement products in the future.This study demonstrates that choosing cleaning products that are marketed as green may reduce exposure to several carcinogens and endocrine disruptors. Future studies should determine whether use of unscented green products would further reduce exposure to terpenes and musks. https://doi.org/10.1289/EHP8831.
Abstract 11347: Beneficial Effects of Drug-eluting Stents With Bioabsorbable Polymer Coating on Coronary Hyperconstricting Responses and Adventitial Vasa Vasorum Formation in Patients With Angina Pectoris -An Intracoronary OCT Study-
Authors: Kiyoto Mitsuishi, Kensuke Nishimiya, Yasuharu Matsumoto, Tasuku Watanabe, Satoshi Tsuchiya, Jun Sugisawa, Koichi Satoh, Akira Suda, Tomohiko Shindo, Shigeo Godo, Shohei Ikeda, Kiyotaka Hao, Yoku Kikuchi, Jun Takahashi, Hiroaki Shimokawa
Journal: Circulation (2019)

Introduction: Drug-eluting stents (DES) cause coronary hyperconstricting responses with resultant unremitting angina after stenting. We have previously demonstrated that residual polymer coating ca...
RETRACTED ARTICLE: SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion
Authors: Xinling Wang, Wei Xu, Gaowei Hu, Shuai Xia, Zhiping Sun, Zezhong Liu, Youhua Xie, Rong Zhang, Shibo Jiang, Lu Lu
Journal: Cellular and Molecular Immunology (2020)

conclusions being considered invalid.
Group 2 innate lymphoid cells in patients with nonasthmatic eosinophilic bronchitis
Authors: Chen Zhan, Jiaxing Liu, Bizhou Li, Rong Xu, Wanqin Liang, Shengfang Zhang, Liman Fang, Shuxin Zhong, S. Dushinka Shaniya Helen de Silva, Dhinesan Sivapalan, Wei Luo, Hongyu Wang, Jing Li, Kefang Lai, Nanshan Zhong, Roma Sehmi, Paul M O’Byrne, Ruchong Chen
Journal: Allergy (2021)

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Lysosomes in acute myeloid leukemia: potential therapeutic targets?
Authors: Sreoshee Rafiq, Sharon L. McKenna, Sylviane Muller, Mario P. Tschan, Magali Humbert
Journal: Leukemia (2021)

Abstract Lysosomes, since their discovery, have been primarily known for degrading cellular macromolecules. However, in recent studies, they have begun to emerge as crucial regulators of cell homeostasis. They are at the crossroads of catabolic and anabolic pathways and are intricately involved in cellular trafficking, nutrient signaling, energy metabolism, and immune regulation. Their involvement in such essential cellular functions has renewed clinical interest in targeting the lysosome as a novel way to treat disease, particularly cancer. Acute myeloid leukemia (AML) is an aggressive blood cancer with a low survival probability, particularly in older patients. The genomic landscape of AML has been extensively characterized but few targeted therapies (with the exception of differentiation therapy) can achieve a long-term cure. Therefore, there is an unmet need for less intensive and more tolerable therapeutic interventions. In this review, we will give an overview on the myriad of functions performed by lysosomes and their importance in malignant disease. Furthermore, we will discuss their relevance in hematopoietic cells and different ways to potentially target them in AML.
Biochemically deleterious human <i>NFKB1</i> variants underlie an autosomal dominant form of common variable immunodeficiency
Authors: Juan Li, Wei-Te Lei, Peng Zhang, Franck Rapaport, Yoann Seeleuthner, Bingnan Lyu, Takaki Asano, Jérémie Rosain, Boualem Hammadi, Yu Zhang, Simon J. Pelham, András N. Spaan, Mélanie Migaud, David Hum, Benedetta Bigio, Maya Chrabieh, Vivien Béziat, Jacinta Bustamante, Shen-Ying Zhang, Emmanuelle Jouanguy, Stephanie Boisson-Dupuis, Jamila El Baghdadi, Vishukumar Aimanianda, Katharina Thoma, Manfred Fliegauf, Bodo Grimbacher, Anne-Sophie Korganow, Carol Saunders, V. Koneti Rao, Gulbu Uzel, Alexandra F. Freeman, Steven M. Holland, Helen C. Su, Charlotte Cunningham-Rundles, Claire Fieschi, Laurent Abel, Anne Puel, Aurélie Cobat, Jean-Laurent Casanova, Qian Zhang, Bertrand Boisson
Journal: The Journal of Experimental Medicine (2021)

Autosomal dominant (AD) NFKB1 deficiency is thought to be the most common genetic etiology of common variable immunodeficiency (CVID). However, the causal link between NFKB1 variants and CVID has not been demonstrated experimentally and genetically, and there has been insufficient biochemical characterization and enrichment analysis. We show that the cotransfection of NFKB1-deficient HEK293T cells (lacking both p105 and its cleaved form p50) with a κB reporter, NFKB1/p105, and a homodimerization-defective RELA/p65 mutant results in p50:p65 heterodimer–dependent and p65:p65 homodimer–independent transcriptional activation. We found that 59 of the 90 variants in patients with CVID or related conditions were loss of function or hypomorphic. By contrast, 258 of 260 variants in the general population or patients with unrelated conditions were neutral. None of the deleterious variants displayed negative dominance. The enrichment in deleterious NFKB1 variants of patients with CVID was selective and highly significant (P = 2.78 × 10−15). NFKB1 variants disrupting NFKB1/p50 transcriptional activity thus underlie AD CVID by haploinsufficiency, whereas neutral variants in this assay should not be considered causal.
Overdiagnosis of Chronic Kidney Disease in Older Adults—An Inconvenient Truth
Authors: Ann M. O’Hare, Rudolph A. Rodriguez, Andrew D. Rule
Journal: JAMA Internal Medicine (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
SERUM AND VACCINE THERAPY IN CONNEXION WITH DISEASES OF THE EYE: The Middlemore Prize Essay, British Medical Association, 1911
Authors: C. W. G. Bryan
Journal: BMJ (1912)

tMARCH 30, 19T2. MIIDICAL JOURNA and( miiale a lunmbar puncture.In January this childl much im- prov-ed, but cannot use right leg.A. B.. aged 1l years, occupyinig the same room, became ill with loss of power in back, cannot sit up and cries if benit.' Temperature nornmal, limbs uiiaffected.Case vI (lie(l in Janiuary from bronchopneumonia.. CASE VIII (
Steps per Day and All-Cause Mortality in Middle-aged Adults in the Coronary Artery Risk Development in Young Adults Study
Authors: Amanda E. Paluch, Kelley Pettee Gabriel, Janet E. Fulton, Cora E. Lewis, Pamela J. Schreiner, Barbara Sternfeld, Stephen Sidney, Juned Siddique, Kara M. Whitaker, Mercedes R. Carnethon
Journal: JAMA Network Open (2021)

Steps per day is a meaningful metric for physical activity promotion in clinical and population settings. To guide promotion strategies of step goals, it is important to understand the association of steps with clinical end points, including mortality.To estimate the association of steps per day with premature (age 41-65 years) all-cause mortality among Black and White men and women.This prospective cohort study was part of the Coronary Artery Risk Development in Young Adults (CARDIA) study. Participants were aged 38 to 50 years and wore an accelerometer from 2005 to 2006. Participants were followed for a mean (SD) of 10.8 (0.9) years. Data were analyzed in 2020 and 2021.Daily steps volume, classified as low (<7000 steps/d), moderate (7000-9999 steps/d), and high (≥10 000 steps/d) and stepping intensity, classified as peak 30-minute stepping rate and time spent at 100 steps/min or more.All-cause mortality.A total of 2110 participants from the CARDIA study were included, with a mean (SD) age of 45.2 (3.6) years, 1205 (57.1%) women, 888 (42.1%) Black participants, and a median (interquartile range [IQR]) of 9146 (7307-11 162) steps/d. During 22 845 person years of follow-up, 72 participants (3.4%) died. Using multivariable adjusted Cox proportional hazards models, compared with participants in the low step group, there was significantly lower risk of mortality in the moderate (hazard ratio [HR], 0.28 [95% CI, 0.15-0.54]; risk difference [RD], 53 [95% CI, 27-78] events per 1000 people) and high (HR, 0.45 [95% CI, 0.25-0.81]; RD, 41 [95% CI, 15-68] events per 1000 people) step groups. Compared with the low step group, moderate/high step rate was associated with reduced risk of mortality in Black participants (HR, 0.30 [95% CI, 0.14-0.63]) and in White participants (HR, 0.37 [95% CI, 0.17-0.81]). Similarly, compared with the low step group, moderate/high step rate was associated with reduce risk of mortality in women (HR, 0.28 [95% CI, 0.12-0.63]) and men (HR, 0.42 [95% CI, 0.20-0.88]). There was no significant association between peak 30-minute intensity (lowest vs highest tertile: HR, 0.98 [95% CI, 0.54-1.77]) or time at 100 steps/min or more (lowest vs highest tertile: HR, 1.38 [95% CI, 0.73-2.61]) with risk of mortality.This cohort study found that among Black and White men and women in middle adulthood, participants who took approximately 7000 steps/d or more experienced lower mortality rates compared with participants taking fewer than 7000 steps/d. There was no association of step intensity with mortality.
High Grade B Cell Lymphoma with MYC and BCL2 and/or BCL6 Rearrangements Depict a High Complexity on the Cytogenetic, but Not on the Molecular Genetic Level and Show MYC Mutations As Prognostic Marker
Authors: Anna Stengel, Wolfgang Kern, Manja Meggendorfer, Torsten Haferlach, Claudia Haferlach
Journal: Blood (2017)
Using Wastewater Surveillance Data to Support the COVID-19 Response — United States, 2020–2021
Authors: Amy E. Kirby, Maroya Spalding Walters, Wiley C. Jennings, Rebecca Fugitt, Nathan LaCross, Mia Mattioli, Zachary A. Marsh, Virginia A. Roberts, Jeffrey W. Mercante, Jonathan Yoder, Vincent R. Hill
Journal: MMWR Morbidity and Mortality Weekly Report (2021)

Wastewater surveillance, the measurement of pathogen levels in wastewater, is used to evaluate community-level infection trends, augment traditional surveillance that leverages clinical tests and services (e.g., case reporting), and monitor public health interventions (1). Approximately 40% of persons infected with SARS-CoV-2, the virus that causes COVID-19, shed virus RNA in their stool (2); therefore, community-level trends in SARS-CoV-2 infections, both symptomatic and asymptomatic (2) can be tracked through wastewater testing (3-6). CDC launched the National Wastewater Surveillance System (NWSS) in September 2020 to coordinate wastewater surveillance programs implemented by state, tribal, local, and territorial health departments to support the COVID-19 pandemic response. In the United States, wastewater surveillance was not previously implemented at the national level. As of August 2021, NWSS includes 37 states, four cities, and two territories. This report summarizes NWSS activities and describes innovative applications of wastewater surveillance data by two states, which have included generating alerts to local jurisdictions, allocating mobile testing resources, evaluating irregularities in traditional surveillance, refining health messaging, and forecasting clinical resource needs. NWSS complements traditional surveillance and enables health departments to intervene earlier with focused support in communities experiencing increasing concentrations of SARS-CoV-2 in wastewater. The ability to conduct wastewater surveillance is not affected by access to health care or the clinical testing capacity in the community. Robust, sustainable implementation of wastewater surveillance requires public health capacity for wastewater testing, analysis, and interpretation. Partnerships between wastewater utilities and public health departments are needed to leverage wastewater surveillance data for the COVID-19 response for rapid assessment of emerging threats and preparedness for future pandemics.
Publisher Correction: Global epidemiology of systemic lupus erythematosus
Authors: Megan R. W. Barber, Cristina Drenkard, Titilola Falasinnu, Alberta Hoi, Anselm Mak, Nien Yee Kow, Elisabet Svenungsson, Jonna Peterson, Ann E. Clarke, Rosalind Ramsey-Goldman
Journal: Nature Reviews Rheumatology (2021)
The genomic architecture of EBV and infected gastric tissue from precursor lesions to carcinoma
Authors: Zhang-Hua Chen, Shu-Mei Yan, Xi-Xi Chen, Qi Zhang, Shang-Xin Liu, Yang Liu, Yi-Ling Luo, Chao Zhang, Miao Xu, Yi-Fan Zhao, Li-Yun Huang, Bin-Liu Liu, Tian-Liang Xia, Da-Zhi Xu, Yao Liang, Yong-Ming Chen, Wei Wang, Shu-Qiang Yuan, Hui-Zhong Zhang, Jing-Ping Yun, Wei-Wei Zhai, Mu-Sheng Zeng, Fan Bai, Qian Zhong
Journal: Genome Medicine (2021)

Epstein-Barr virus (EBV)-associated gastric carcinomas (EBVaGCs) present unique molecular signatures, but the tumorigenesis of EBVaGCs and the role EBV plays during this process remain poorly understood.
Deoxyhypusine synthase promotes a pro-inflammatory macrophage phenotype
Authors: Emily Anderson-Baucum, Annie R Piñeros, Abhishek Kulkarni, Bobbie-Jo Webb-Robertson, Bernhard Maier, Ryan M Anderson, Wenting Wu, Sarah A Tersey, Teresa L Mastracci, Isabel Casimiro, Donalyn Scheuner, Thomas O Metz, Ernesto S Nakayasu, Carmella Evans-Molina, Raghavendra G Mirmira
Journal: Cell Metabolism (2021)

The metabolic inflammation (meta-inflammation) of obesity is characterized by proinflammatory macrophage infiltration into adipose tissue. Catalysis by deoxyhypusine synthase (DHPS) modifies the translation factor eIF5A to generate a hypusine (Hyp) residue. Hypusinated eIF5A (eIF5AHyp) controls the translation of mRNAs involved in inflammation, but its role in meta-inflammation has not been elucidated. Levels of eIF5AHyp were found to be increased in adipose tissue macrophages from obese mice and in murine macrophages activated to a proinflammatory M1-like state. Global proteomics and transcriptomics revealed that DHPS deficiency in macrophages altered the abundance of proteins involved in NF-κB signaling, likely through translational control of their respective mRNAs. DHPS deficiency in myeloid cells of obese mice suppressed M1 macrophage accumulation in adipose tissue and improved glucose tolerance. These findings indicate that DHPS promotes the post-transcriptional regulation of a subset of mRNAs governing inflammation and chemotaxis in macrophages and contributes to a proinflammatory M1-like phenotype.
Inherently nitric oxide containing polymersomes remotely regulated by NIR for improving multi-modal therapy on drug resistant cancer
Authors: Zhihong Liu, Yinan Zhong, Xiang Zhou, Xin Huang, Jingjing Zhou, Dechun Huang, Yanfei Li, Zhixiang Wang, Bin Dong, Haishi Qiao, Wei Chen
Journal: Biomaterials (2021)