tbuckley/cabot-search huggingface dataset:
Inhibition of plasma‐mediated adherence of sickle erythrocytes to microvascular endothelium by conformationally constrained RGD‐containing peptides
Authors: Anjali Kumar, James R. Eckman, Timothy M. Wick
Journal: American Journal of Hematology (1996)

Adherence of sickle erythrocytes to vascular endothelium likely initiates or participates in microvascular occlusion, leading to ischemic tissue and organ damage characteristic of sickle-cell pain episodes. In vitro, sickle-cell adherence to endothelium involves adhesive plasma proteins and integrin and nonintegrin receptors on sickle cells and endothelial cells. The involvement of arginine-glycine-aspartic acid (RGD) sequences in adhesive plasma proteins and integrin receptors suggests that RGD-containing peptides may inhibit sickle-cell/endothelial-cell adherence. In the present study, inhibition of plasma-mediated sickle-erythrocyte adherence to endothelium using conformationally constrained RGD-containing peptides was quantified in vitro under continuous flow at a shear stress of 1.0 dyn/cm2. Two conformationally constrained RGD peptides were investigated: 6Z (which has high affinity for α5β1, αvβ3, and αIIIbβ3 integrin receptors), and TP9201 (which preferentially binds to αIIbβ3). Peptide 6Z at 50 μM inhibited plasma-mediated sickle-cell adherence to microvascular endothelium 70% when incubated with sickle red cells, and 63% when incubated with endothelium. Under similar conditions, peptide TP9201 inhibited plasma-mediated sickle-cell adherence up to 85% at concentrations from 250 to 500 μM TP9201. The inhibition of plasma-mediated adherence by conformationally constrained RGD peptides, but not by linear or circular constructs, suggests that the tertiary structure of the peptide containing the binding sequence is important. Inhibition of plasma-mediated sickle-cell adhesion with these peptides in vitro suggests that such conformationally constrained RGD peptides could provide therapeutic interventions in the course of the disease by inhibiting receptor-ligand interactions. © 1996 Wiley-Liss, Inc.
A piece of my mind. Check kiting: lessons from a master
Authors: M. A. LaCombe
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Listings
Journal: Annals of Internal Medicine (2001)

Book Listings20 November 2001Book ListingsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-10-200111200-00033 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail CardiologyCardioFaxDA Tighe, JR Cook, MJ Schweiger, and EK Chung. 239 pages. Cambridge, MA: Blackwell Science; 2001. $30.00. ISBN 0865425639. Order phone 800-759-6102.Coronary Artery Stenting: A Case-Oriented ApproachN Curzen and MT Rothman, eds. 194 pages. Philadelphia: Taylor&Francis; 2001. $120.00. ISBN 1853177180. Order phone 800-821-8312.Evidence-Based Manual of Coronary Care ManagementM Connaughton. 195 pages. Philadelphia: WB Saunders; 2001. $35.00. ISBN 0443064156. Order phone 215-238-7800.Fundamental Approaches to the Management of Cardiac ArrhythmiasRJ Sung and MR Lauer. 804 pages. Boston: Kluwer; 2000. $350.00. ISBN 0792365593. Order phone 781-871-1660.Heart Disease: Review and Assessment4th edition. LS Lilly. 268 pages. Philadelphia: WB Saunders; ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 November 2001Volume 135, Issue 10Page: B1KeywordsBehaviorCellsPrevention, policy, and public health ePublished: 20 November 2001 Issue Published: 20 November 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.Loading ...
Extrapolating neurogenesis of mesenchymal stem/stromal cells on electroactive and electroconductive scaffolds to dental and oral-derived stem cells
Authors: Boon Chin Heng, Yunyang Bai, Xiaochan Li, Xuehui Zhang, Xuliang Deng
Journal: International Journal of Oral Science (2022)

The high neurogenic potential of dental and oral-derived stem cells due to their embryonic neural crest origin, coupled with their ready accessibility and easy isolation from clinical waste, make these ideal cell sources for neuroregeneration therapy. Nevertheless, these cells also have high propensity to differentiate into the osteo-odontogenic lineage. One strategy to enhance neurogenesis of these cells may be to recapitulate the natural physiological electrical microenvironment of neural tissues via electroactive or electroconductive tissue engineering scaffolds. Nevertheless, to date, there had been hardly any such studies on these cells. Most relevant scientific information comes from neurogenesis of other mesenchymal stem/stromal cell lineages (particularly bone marrow and adipose tissue) cultured on electroactive and electroconductive scaffolds, which will therefore be the focus of this review. Although there are larger number of similar studies on neural cell lines (i.e. PC12), neural stem/progenitor cells, and pluripotent stem cells, the scientific data from such studies are much less relevant and less translatable to dental and oral-derived stem cells, which are of the mesenchymal lineage. Much extrapolation work is needed to validate that electroactive and electroconductive scaffolds can indeed promote neurogenesis of dental and oral-derived stem cells, which would thus facilitate clinical applications in neuroregeneration therapy.
Lumbar Discography
Authors: Oscar Sugar
Journal: JAMA (1963)

The author has utilized the statistics drawn from Gardner's 1,014 cases of lumbar discography done at the Cleveland Clinic. The essential part of the monograph was presented at the Cushing Society Meeting in Mexico in 1961 (published in<i>J Neurosurg</i><b>19</b>:452-461, 1962). In this amplification there is more detail on the embryology, anatomy, and physiology of the disc; an atlas of roentgenograms and line drawings taken from 6 normal and 20 abnormal cases; and a chapter on statistical analysis in which correlations are drawn concerning the discogram, pain on injection in the disc, clinical findings, operative findings, and plain roentgenograms. The technique of discography is presented along with a table which permits the procedure to be done in a kneeling position. Collis stresses the importance of leaving the needles in place until the roentgenograms are done, lest backleakage of dye obscure the findings. In his opinion, no damage is
Magnetic Resonance Imaging
Authors: Alex M. Aisen
Journal: JAMA (1993)

This two-volume set is a welcome and first-rate revision of what has become one of the standard texts on the burgeoning radiological subspecialty of magnetic resonance imaging, or MRI. The book attempts to be inclusive and succeeds reasonably well. It begins with 500-odd pages providing some overview material on physics, safety, and economics. The remainder of the work is divided in the traditional manner, by organ system. Thus, a large section on the brain is followed by material on the spine. Chapters then progress from the heart, through the abdomen, and into the pelvis. The concluding material covers the musculoskeletal system, which has become one of MRI's major applications. Most of the chapters are well written. The large introductory section provides a good summary of magnetic resonance physics and imaging phenomenology and will be especially helpful to those new to MRI. The remainder is concerned with the diagnostic applications of
Fracture of the Month 24
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SARS-CoV-2 B.1.1.529 (Omicron) Variant Transmission Within Households — Four U.S. Jurisdictions, November 2021–February 2022
Authors: Julia M. Baker, Jasmine Y. Nakayama, Michelle O’Hegarty, Andrea McGowan, Richard A. Teran, Stephen M. Bart, Katie Mosack, Nicole Roberts, Brooke Campos, Alina Paegle, John McGee, Robert Herrera, Kayla English, Carla Barrios, Alexandria Davis, Christine Roloff, Lynn E. Sosa, Jessica Brockmeyer, Lindsey Page, Amy Bauer, Joshua J. Weiner, Manjeet Khubbar, Sanjib Bhattacharyya, Hannah L. Kirking, Jacqueline E. Tate
Journal: MMWR Morbidity and Mortality Weekly Report (2022)

The B.1.1.529 (Omicron) variant, first detected in November 2021, was responsible for a surge in U.S. infections with SARS-CoV-2, the virus that causes COVID-19, during December 2021-January 2022 (1). To investigate the effectiveness of prevention strategies in household settings, CDC partnered with four U.S. jurisdictions to describe Omicron household transmission during November 2021-February 2022. Persons with sequence-confirmed Omicron infection and their household contacts were interviewed. Omicron transmission occurred in 124 (67.8%) of 183 households. Among 431 household contacts, 227 were classified as having a case of COVID-19 (attack rate [AR] = 52.7%).† The ARs among household contacts of index patients who had received a COVID-19 booster dose, of fully vaccinated index patients who completed their COVID-19 primary series within the previous 5 months, and of unvaccinated index patients were 42.7% (47 of 110), 43.6% (17 of 39), and 63.9% (69 of 108), respectively. The AR was lower among household contacts of index patients who isolated (41.2%, 99 of 240) compared with those of index patients who did not isolate (67.5%, 112 of 166) (p-value <0.01). Similarly, the AR was lower among household contacts of index patients who ever wore a mask at home during their potentially infectious period (39.5%, 88 of 223) compared with those of index patients who never wore a mask at home (68.9%, 124 of 180) (p-value <0.01). Multicomponent COVID-19 prevention strategies, including up-to-date vaccination, isolation of infected persons, and mask use at home, are critical to reducing Omicron transmission in household settings.
Rev Française d'Études Clin Biol, Paris
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Issue Information
Authors: Daniel Solomon, Richard Bucala, New Haven, Mariana Kaplan, Peter Nigrovic, Boston Co, Karen Costenbader, David Felson, Richard Loeser, Chapel Hill, Paul Sufka, St Paul, Shervin Assassi, Vivian Bykerk, New York, Kristin D'silva, Deborah Feldman, Meenakshi Jolly, Linda Li, Uyen-Sa Nguyen, Worth Fort, Oklahoma Scofield, Jane Diamond, Atlanta Ilani, S Lorber, Atlanta Lesley, W Allen, Atlanta Barraza, Emily Wehby, Atlanta Stefanie, L Mckain, Atlanta Swett, Haven Galanis, Marta Alarcón-Riquelme, Heather Allore, Neal Basu, Bryce Binstadt, John Carrino, Lisa Christopher-Stine, Baltimore Cope, Nicola Dalbeth, Brian Feldman, Richard Furie, Great Neck, J Kahlenberg, Ann Arbor, Benjamin Leder, Yvonne Lee, Katherine Liao, Anne-Marie Malfait, Stephen Messier, Winston-Salem Janet, E Pope, Christopher Ritchlin, Rochester Robinson, Georg Schett, Sakae Tanaka, Maria Trojanowska, Betty Tsao, Fredrick Wigley, Abhishek Abhishek, Nottingham Aghayev, Tom Appleton, Joshua Baker, Bonnie Bermas, Dallas Denton, Anisha Dua, John Fitzgerald, Angeles Haroon, Monique Hinchcliff, Hui-Chen Hsu, Vasileios Kyttaris, Rik Lories, Suresh Mahalingam, Dennis Mcgonagle, Aridaman Pandit, Kevin Winthrop, Julie Zikherman, Francisco American, Ellen Gravallese, David Karp, Douglas White, La Crosse, Kenneth Saag, Steven Echard, Lauren Henderson, Scott Canna, Kevin Friedman, Mark Gorelik, Sivia Lapidus, Hamid Bassiri, Edward Behrens, Anne Ferris, Kate Kernan, Grant Schulert, Philip Seo, Mary Beth, F Son, Adriana Tremoulet, Rae Yeung, Dawn Wahezi, Mindy Lo, Tamar Rubinstein, Sarah Ringold, Stacy Ardoin, Kevin Downes, Karla Jones, Ronald Laxer, Rebecca Madan, Andrea Matteo, Kulveer Mankia, Laurence Duquenne, Michael Mahler, Diane Corscadden, Katie Mbara
Journal: Arthritis & Rheumatology (2020)
BET-bromodomain and EZH2 inhibitor–treated chronic GVHD mice have blunted germinal centers with distinct transcriptomes
Authors: Michael C. Zaiken, Ryan Flynn, Katelyn G. Paz, Stephanie Y. Rhee, Sujeong Jin, Fathima A. Mohamed, Asim Saha, Govindarajan Thangavelu, Paul M. C. Park, Matthew L. Hemming, Peter T. Sage, Arlene H. Sharpe, Michel DuPage, Jeffrey A. Bluestone, Angela Panoskaltsis-Mortari, Corey S. Cutler, John Koreth, Joseph H. Antin, Robert J. Soiffer, Jerome Ritz, Leo Luznik, Ivan Maillard, Geoffrey R. Hill, Kelli P. A. MacDonald, David H. Munn, Jonathan S. Serody, William J. Murphy, Leslie S. Kean, Yi Zhang, James E. Bradner, Jun Qi, Bruce R. Blazar
Journal: Blood (2022)
Incorrect Ampicillin Form
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Global, regional, and national minimum estimates of children affected by COVID-19-associated orphanhood and caregiver death, by age and family circumstance up to Oct 31, 2021: an updated modelling study
Authors: H Juliette T Unwin, Susan Hillis, Lucie Cluver, Seth Flaxman, Philip S Goldman, Alexander Butchart, Gretchen Bachman, Laura Rawlings, Christl A Donnelly, Oliver Ratmann, Phil Green, Charles A Nelson, Alexandra Blenkinsop, Samir Bhatt, Chris Desmond, Andrés Villaveces, Lorraine Sherr
Journal: The Lancet Child & Adolescent Health (2022)

In the 6 months following our estimates from March 1, 2020, to April 30, 2021, the proliferation of new coronavirus variants, updated mortality data, and disparities in vaccine access increased the amount of children experiencing COVID-19-associated orphanhood. To inform responses, we aimed to model the increases in numbers of children affected by COVID-19-associated orphanhood and caregiver death, as well as the cumulative orphanhood age-group distribution and circumstance (maternal or paternal orphanhood).
This Week in &lt;EMPH&gt;JAMA&lt;/EMPH&gt;
Journal: JAMA (2001)

Contempo UpdatesChoosing a revascularization method for treatment of patients with coronary artery disease. SEE PAGE 992 Medical News & PerspectivesFormer injection drug users receiving methadone maintenance therapy who are infected with hepatitis C virus face barriers to getting treatment for their illness. SEE PAGE 1003 Prenatal Diagnosis of Down SyndromeMeta-analysis of data from 56 articles indicates that second-trimester ultrasonographic markers are not sufficiently sensitive for detection of fetuses with Down syndrome to be useful as a screening test.
A guide for the diagnosis of rare and undiagnosed disease: beyond the exome
Authors: Shruti Marwaha, Joshua W. Knowles, Euan A. Ashley
Journal: Genome Medicine (2022)

Abstract Rare diseases affect 30 million people in the USA and more than 300–400 million worldwide, often causing chronic illness, disability, and premature death. Traditional diagnostic techniques rely heavily on heuristic approaches, coupling clinical experience from prior rare disease presentations with the medical literature. A large number of rare disease patients remain undiagnosed for years and many even die without an accurate diagnosis. In recent years, gene panels, microarrays, and exome sequencing have helped to identify the molecular cause of such rare and undiagnosed diseases. These technologies have allowed diagnoses for a sizable proportion (25–35%) of undiagnosed patients, often with actionable findings. However, a large proportion of these patients remain undiagnosed. In this review, we focus on technologies that can be adopted if exome sequencing is unrevealing. We discuss the benefits of sequencing the whole genome and the additional benefit that may be offered by long-read technology, pan-genome reference, transcriptomics, metabolomics, proteomics, and methyl profiling. We highlight computational methods to help identify regionally distant patients with similar phenotypes or similar genetic mutations. Finally, we describe approaches to automate and accelerate genomic analysis. The strategies discussed here are intended to serve as a guide for clinicians and researchers in the next steps when encountering patients with non-diagnostic exomes.
Abstracts
Authors: A Meikle, William Jubiz, Shigeru Matsukura, Charles West, Frank Tyler, Salt Lake, Harold Menkes, Robert Rogers, Kazuaki Sera, Richard Hyde, Robert Forster, Arthur Dubois, Pa Sexual, Ateliotic Dwarfism, Diabetes Mellitus, J Thomas, Judith Hall, David Rimoin, Samuel Fineberg, Victor Mc- Kusicr
Journal: Journal of Clinical Investigation (1969)

After chronic diphenylhydantoin (DPH) therapy the conventional oral metyrapone test is known to produce sub- normal responses.In this study we investigated whether DPH interferes with inhibition of ll1,-hydroxylation induced by metyrapone, the release of ACTH, the absorption of oral metyrapone, or its splanchnic metabolism.With the standard oral metyrapone dose, 750 mg q. 4 hr-6 times, the decrease of plasma cortisol and the increases of li-deoxycortisol, ACTH, and free metyrapone in plasma were all significantly less in the DPH-treated group.The double oral dose, 750 mg q. 2 hr 12 times, and the standard 5.0 g i.v.infusion produced normal steroid and ACTH responses.The dis- appearance of i.v.administered metyrapone was not significantly faster.We concluded that after chronic DPH treatment (1) ACTH release is normal, (2) oral metyrapone produces a lower plasma level of metyrapone, and (3) the splanchnic metabolism of oral metyrapone and/or gastrointestinal absorption may be altered.
THE MULTIPLE DISCIPLINE RESEARCH FORUM
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Handbuch der Hals-Nasen-Ohren-Heilkunde.
Journal: JAMA (1926)

It is impossible in an ordinary review to give any adequate idea of the stupendous work involved in this volume. The mere mention of the names of some of the contributors gives some index of the caliber of the publications: Prof. William Brock on comparative anatomy; Prof. Gustav Alexander on embryology and anthropology; Dr. Herman Marx on malformations of the ear; Professor Koerner on applied anatomy of the ear; Dr. Eckert Moebius on microscopic examination and histology of the ear; Dr. G. Anton on the centers and tracks of the nervus cochlearis and the nervus vestibuli; Karl L. Schaefer and Max Giesswein on physiology of the ear; Prof. H. Neumann and Dr. F. Fremel on physiology of the semicircular canal. Under the heading of pathology and therapy we find such names as Dozent Oscar Beck and Prof. F. R. Nager. This encyclopedic volume holds a world of information and a