tbuckley/cabot-search huggingface dataset:
Shall The Journal be Removed to Washington?
Authors: J. A. Hines
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Optimal Use Of Limited Colonoscopy Capacity in a Fit-Based Crc Screening Program During Covid-19 Pandemic
Authors: L de Jonge, HJ van de Schootbrugge-Vandermeer, ECH Breekveldt, MCW Spaander, AJ van Vuuren, FJ van Kemenade, CRB Ramakers, E Dekker, ID Nagtegaal, ME Van Leerdam, I Lansdorp-Vogelaar
Journal: Endoscopy (2021)

Aims A second wave of the COVID-19 pandemic may force many health care providers to downscale their services again, including colonoscopies which may impact capacity for colorectal cancer (CRC) screening. This study aimed to determine the optimal measure to handle these temporary shortages in colonoscopy capacity in the Dutch national CRC screening program to retain as much of the preventive effect of the screening program as possible.
Consequences of reocclusion after successful reperfusion therapy in acute myocardial infarction. TAMI Study Group.
Authors: E MOhman, R MCaliff, E JTopol, RCandela, CAbbottsmith, SEllis, K NSigmon, DKereiakes, BGeorge, RStack
Journal: Circulation (1990)

To determine the clinical consequences of reocclusion of an infarct-related artery after reperfusion therapy, we evaluated 810 patients with acute myocardial infarction. Patients were admitted into four sequential studies with similar entry criteria in which patency of the infarct-related artery was assessed by coronary arteriography 90 minutes after onset of thrombolytic therapy. Successful reperfusion was established acutely in 733 patients. Thrombolytic therapy included tissue-type plasminogen activator (t-PA) in 517, urokinase in 87, and a combination of t-PA and urokinase in 129 patients. All patients received aspirin, intravenous heparin and nitroglycerin, and diltiazem during the recovery phase. A repeat coronary arteriogram was performed in 88% of patients at a median of 7 days after the onset of symptoms. Reocclusion of the infarct-related artery occurred in 91 patients (12.4%), and 58% of these were symptomatic. Angiographic characteristics at 90 minutes after thrombolytic therapy that were asso...
Randomized study to evaluate the relation between oral isosorbide dinitrate dosing interval and the development of early tolerance to its effect on left ventricular filling pressure in patients with chronic heart failure.
Authors: UElkayam, ARoth, AMehra, EOstrzega, AShotan, DKulick, MJamison, J VJohnston, S HRahimtoola
Journal: Circulation (1991)

BACKGROUNDEarly development of nitrate tolerance has been shown in patients with chronic congestive heart failure (CHF) receiving continuous nitroglycerin therapy. The influence of dosing interval of oral isosorbide dinitrate (ISDN), the nitrate preparation most widely used for the treatment of CHF, has not been investigated.METHODS AND RESULTSWe performed a prospective, randomized study to evaluate the effect of various regimens of oral ISDN on the development of early tolerance to its effect on left ventricular filling pressure in patients with moderate to severe CHF. Forty-four responders (20% or greater reduction in mean pulmonary artery wedge pressure lasting 1 hour or longer) were divided into four groups of 11 patients each, and randomized to receive their effective ISDN dose (40-120 mg) Q 4 hours, Q 6 hours, Q 8 hours, or t.i.d. (drug given at 0, 6, 12, and 24 hours allowing 12 hours of ISDN washout interval between the third and fourth doses). All groups demonstrated a significant and comparable ...
Physiologic mechanisms in aortic insufficiency. I. The effect of changing heart rate on flow dynamics. II. Determinants of Austin Flint murmur.
Authors: SLaniado, E LYellin, CYoran, JStrom, MHori, SGabbay, RTerdiman, R WFrater
Journal: Circulation (1982)

We studied the dynamic changes in mitral flow patterns and in mitral valve motion before and after producing acute, reversible aortic insufficiency (AI) in nine open-chest dogs. Phasic mitral flow, the mitral valve echocardiogram, and intracardiac phonocardiogram and other hemodynamic variables were measured. During moderate AI (mean regurgitant fraction 52 +/- 5%) (+/- SD), the antegrade filling volume decreased from 31 +/- 7 to 24 +/- 6 ml (p less than 0.01), but the peak protodiastolic mitral flow rate increased from 139 +/- 37 to 157 +/- 42 ml/sec (p less than 0.01), reflecting the shift of a larger fraction of total mitral filling volume to early diastole. In six dogs, atrial pacing was used to examine the hemodynamic effects of tachycardia. Increasing the heart rate from 90 to 120 beats/min increased cardiac output from 2.64 +/- 0.56 to 3.3 +/- 0.831/min (p less than 0.05) and decreased left atrial pressure from 24 +/- 8 to 17 +/- 7 mm Hg (p less than 0.05). Increasing heart rate to 150 beats/min co...
Quantitative analysis of infarct size, contraction band necrosis, and coagulation necrosis in human autopsied hearts with acute myocardial infarction after treatment with selective intracoronary thrombolysis.
Authors: MMatsuda, HFujiwara, TOnodera, MTanaka, D JWu, TFujiwara, YHamashima, CKawai
Journal: Circulation (1987)

To assess the importance of contraction band necrosis (CBN) in patients with acute myocardial infarction (AMI) treated with selective intracoronary thrombolysis, CBN, coagulation necrosis, and infarct size (expressed as CBN + coagulation necrosis) were analyzed quantitatively in 16 autopsied hearts. Intracoronary thrombolysis was performed from 2 to 6 hr after the onset of AMI, and the time from the onset of AMI to death was 7 to 168 hr. Cineangiography revealed no evidence of good collateral circulation in any of the patients. The 16 patients were classified into three groups: six patients with successful thrombolysis (100% to 99% stenosis, group I), five patients with unsuccessful thrombolysis (100% to 100%, group II), and five patients with 99% stenosis before thrombolysis (group III). Among the three groups, there were no significant differences in the time from the onset of AMI to thrombolysis, the time from the onset of AMI to death, the cause of death, or the degree of collateral circulation. The p...
High-density lipoprotein cholesterol and premature coronary heart disease in urban Japanese men.
Authors: AKitamura, HIso, YNaito, MIida, MKonishi, A RFolsom, SSato, MKiyama, MNakamura, TSankai
Journal: Circulation (1994)

BACKGROUNDThe objective of this study was to examine the relation of high-density lipoprotein cholesterol (HDL-C) to coronary heart disease in Japanese men whose serum total cholesterol is low by Western standards.METHODS AND RESULTSA prospective, observational study based on 7.7 years of follow-up for incidence of coronary heart disease and stroke was conducted. The subjects were 6408 middle-aged male workers aged 40 to 59 years at baseline in urban companies in Osaka, Japan, whose mean serum total cholesterol was 5.10 mmol/L. Mean HDL-C adjusted for age, total cholesterol, systolic blood pressure, alcohol intake, cigarette smoking, and body mass index was 1.27 to 1.28 mmol/L for men who developed coronary heart disease (n = 46) or definite myocardial infarction (n = 21) compared with 1.46 mmol/L for those free of cardiovascular disease (n = 6256; difference, P < .01). There was no significant difference in mean HDL-C between stroke cases (n = 33) and those free of cardiovascular disease. The incidence r...
Deep Neural Network for Cecum Achievement Confirmation During Screening Colonoscopy
Authors: S Kashin, D Zavyalov, R Kuvaev, V Khryashchev, A Lebedev, S Guseinova, C Hassan
Journal: Endoscopy (2021)

Aims According to ESGE guidelines, reaching the cecum is a basic aspect of the quality of screening colonoscopy. An artificial intelligence-based approach can be useful in real-time confirmation of cecal achievement and in monitoring the quality of colonoscopy in an endoscopy unit. We checked the ability of computerized image analysis using deep neural network to confirm reaching the cecum in screening colonoscopy.
Heart rate variability during the acute phase of myocardial infarction.
Authors: G CCasolo, PStroder, CSignorini, FCalzolari, MZucchini, EBalli, ASulla, SLazzerini
Journal: Circulation (1992)

BACKGROUNDAfter acute myocardial infarction (AMI), several abnormalities of the autonomic control to the heart have been described. Heart rate (HR) variability has been used to explore the neural control to the heart. A low HR variability count measured 7-13 days after AMI is significantly related to a poor outcome. Little information is available on HR variability early after AMI and its relation to clinical and hemodynamic data.METHODS AND RESULTSWe studied 54 consecutive patients (42 men and 12 women; mean age, 60.4 +/- 11 years) with evidence of AMI by collecting the 24-hour HR SD from Holter tapes recorded on day 2 or 3. We also measured HR variability in 15 patients with unstable angina and in 35 age-matched normal subjects. HR variability was lower in AMI than in unstable angina patients (57.6 +/- 21.3 versus 92 +/- 19 msec; p less than 0.001) and controls (105 +/- 12 msec; p less than 0.001). Also, HR variability was greater in non-Q-wave than in Q-wave AMI (p less than 0.0001) and in recombinant ...
Difference in persistence of efficacy of two antiemetic regimens on acute emesis during cisplatin chemotherapy
Authors: A. Del Favero, E. Ballatori, A. Olivieri, M. Tonato, F. Roila, V. De Angelis, C. Basurto, S. Bracarda, E. Corgna, M. Picciafuoco, L. Patoia, G. Favalli, R. Garbelli, U. A. Bianchi, G. Scarfone, C. Ferraris, M. C. Bolis, F. Cognetti, E. Colella
Journal: Journal of Clinical Oncology (1993)
A plasmatic factor may cause platelet activation in acute ischemic stroke.
Authors: RJoseph, K MWelch, S BOster, SGrunfeld, GD'Andrea
Journal: Circulation Research (1989)

To study the pathogenesis of platelet activation in ischemic stroke, ionized calcium ([Cai2+]) was measured in aequorin-loaded gel-filtered platelets in the basal and stimulated state. Basal [Cai2+] was increased in stroke patients maximally 36-72 hours after onset. The increase in [Cai2+] after stimulation with thrombin, collagen, and platelet-activating factor were also greater in stroke patients, but the profiles of these [Cai2+] changes were parallel to control. Cross incubation of control platelets with plasma from stroke patients resulted in raised basal [Cai2+] and caused the release of serotonin from platelets. These results indicate that the higher platelet basal [Cai2+] in stroke patients represents a lowered threshold for activation and that this may be due to a plasmatic factor rather than a primary platelet defect.
Are clinical trials in coronary heart disease oversold or undersold
Authors: K MDetre, JWare, NMantel
Journal: Circulation (1981)

Randomized clinical trials constitute the formal experiments in therapeutics. Many such trials in coronary heart disease have terminated inconclusively or in controversy. In this editorial, we analyze some of the methodologic issues that may lead to controversy; the main reason for the low success rate may lie in insufficient understanding of the complex biology of the disease and in failure to select the appropriate models for therapy. We argue that these difficulties only strengthen the need for the rigorous experimental approach to the evaluation of therapies for coronary heart disease.
Acquisition Patterns and Interaction of Molecular, Obvious and Cryptic Cytogenetic Abnormalities in Myelodysplastic Syndromes
Authors: Christina Ganster, Katayoon Shirneshan, Sascha Dierks, Roman Martin, Bertram Glass, Haifa Kathrin Al-Ali, Michael Metz, Ulrich Germing, Uwe Platzbecker, Nicolaus Kroeger, Friederike Braulke, Julie Schanz, Lorenz Truemper, Detlef Haase
Journal: Blood (2017)
Recording of diastolic slope with catheters during junctional rhythm in humans.
Authors: R JHariman, J AGomes, NEl-Sherif
Journal: Circulation (1984)

Junctional diastolic slopes were recorded in 11 of 15 patients (73.3%) with junctional rhythm that occurred spontaneously, after intravenous administration of atropine (1 mg), or during carotid sinus massage. The diastolic slopes were recorded through a unipolar lead consisting of a terminal of an electrode catheter placed in the His bundle area paired with an indifferent terminal on the superior vena cava. The slope of these diastolic deflections -0.18 +/- 0.06 m V/sec (mean +/- SD). Overdrive atrial and ventricular stimulations were followed by slowing of the junctional rate and decrease in the diastolic slope. Strong negative correlations (r values from -.71 to -.95) were found between the junctional cycle lengths and the diastolic slopes after atrial or ventricular pacing. Carotid sinus massage decreased the junctional rate and the junctional diastolic slope, whereas atropine increased the junctional rate and the junctional diastolic slope. Since prolongation of junctional cycle lengths after atrial p...
Hemodynamic and neuroendocrine responses to acute and chronic alpha-adrenergic blockade with prazosin and phenoxybenzamine.
Authors: JMulvihill-Wilson, F AGaffney, W APettinger, C GBlomqvist, SAnderson, R MGraham
Journal: Circulation (1983)

We investigated the relevance of the selective alpha 1-adrenergic receptor blockade produced by prazosin to its blood pressure-lowering efficacy in man. The hemodynamic and neuroendocrine responses to the acute and chronic oral administration of prazosin and phenoxybenzamine were compared in a randomized, double-blind, placebo-controlled, crossover study of 11 patients with essential hypertension. These responses were also evaluated during lower body negative pressure and dynamic bicycle exercise, which produce potent but diversified activation of the sympathetic nervous system. In the acute studies, arterial blood pressure decreased to similar levels with prazosin or phenoxybenzamine; however, hemodynamic and neuroendocrine responses differed both before and during sympathetic nervous system activation. Prazosin lowered arterial blood pressure by reducing total peripheral resistance (p less than 0.05). In contrast, phenoxybenzamine produced a modest reduction in cardiac output (8%, p less than 0.05) with...
Lipid solubility modulates pH potentiation of local anesthetic block of Vmax reactivation in guinea pig myocardium.
Authors: ABroughton, A OGrant, C FStarmer, J KKlinger, B SStambler, H CStrauss
Journal: Circulation Research (1984)

Current theories envision recovery from local anesthetic block of sodium channels via slow hydrophilic and fast hydrophobic paths. Extracellular pH reduction which increases cationic/neutral anesthetic form should especially prolong recovery kinetics of highly lipid soluble compounds that could readily exit via the hydrophobic pathway at normal extracellular pH. To test this hypothesis, we compared the effects of three related compounds with similar pKa on the time course of Vmax reactivation in guinea pig papillary muscle at pHo 7.4 and 6.95. The compounds were lidocaine and its two desethylation products, monoethylglycinexylidide and glycinexylidide. Judged from the octanol:water partition coefficient, lidocaine was the most lipid soluble (log partition coefficient 2.39 +/- 0.10), followed by monoethylglycinexylidide (log partition coefficient 1.32 +/- 0.09) and glycinexylidide was the least lipid soluble (log partition coefficient 0.41 +/- 0.09). At 30 microM and pHo 7.4, the potency order for Vmax dep...
Tumor-promoting phorbol esters inhibit cardiac functions and induce redistribution of protein kinase C in perfused beating rat heart.
Authors: S HYuan, F ASunahara, A KSen
Journal: Circulation Research (1987)

Activation of protein kinase C has been implicated in the regulation of a variety of cellular reactions. Although we, and others, have found protein kinase C and its substrate proteins to be present in both membrane and cytosolic fractions in the heart, the physiologic role of this kinase in the regulation of cardiac functions remains unknown. In the present study, we found that in isolated perfused rat heart, administration of phorbol esters 4 beta-phorbol 12,13-dibutyrate(PDBu) and 12-0-tetradecanoylphorbol 13-acetate(TPA), which are specific activators of protein kinase C, produced marked dose-dependent negative changes in inotropy and chronotropy. A dose-dependent decrease in coronary flow was also observed. The diacylglycerol analogues, 1,2-oleoylacetyl-glycerol and 1,2-dioctanoylglycerol, produced similar effects as the active phorbol esters on these isolated perfused hearts. An inactive analogue of phorbol ester, 4 alpha-phorbol, failed to produce any effect. Protein kinase C activity in both membr...
Effects of tissue-type plasminogen activator and anisoylated plasminogen streptokinase activator complex on mortality in acute myocardial infarction.
Authors: P HHeld, K KTeo, SYusuf
Journal: Circulation (1990)

An overview of eight randomized controlled trials of tissue-type plasminogen activator (Alteplase or Duteplase) and 10 of anisoylated plasminogen streptokinase activator complex (Anistreplase) showed that the odds of early death were reduced by 29% by tissue-type plasminogen activator and 46% by anisoylated plasminogen streptokinase activator complex, with overlapping 95% confidence intervals. Although the beneficial effects of both agents are consistent and are strengthened when all the trials are considered together, the available data do not permit comparisons of the relative efficacy of these two agents with each other or with streptokinase.
Mixed malarial infection due to Plasmodium falciparum and P vivax.
Authors: L Savioli, A de Felici, M Grazia Paglia, G Visco
Journal: BMJ (1985)

Une observation: un homme de 29 ans, revenant de l'Inde, semble atteint de paludisme du a la fois a P. falcifarum resistant a la chloroquine et a P. vivax resistant a la primaquine
Recurrence risks in children having one parent with a congenital heart disease.
Authors: J JNora, A HNora
Journal: Circulation (1976)

The risk of recurrence of a congenital cardiovascular malformation in a child having one parent with congenital heart disease has been determined for each of the seven most common anomalies presently compatible with survival to reproductive age. The range of risk is 2.5% to 4.3% depending on the lesion. This is within the range of expectation for the model of multifactorial inheritance previously used to predict recurrence in other first-degree relatives of probands (siblings and parents) with congenital heart disease. The cardiovascular abnormality occurring in the child was most often the same as in the parent or was a closely related variant of it.
Interventricular septal motion in patients with proximal and distal left anterior descending coronary artery lesions.
Authors: M JGordon, R EKerber
Journal: Circulation (1977)

In order to evaluate the ability of the echocardiogram to detect and localize left main or left anterior descending (LAD) coronary artery lesions, 43 patients were studied. The systolic excursion of the left side of the septum and the ratio of posterior wall to septal excursion were measured. Seventeen patients had no LAD lesions; all had systolic septal excursion of 3 mm or greater. Twelve patients with septal excursion of 2 mm or less all had left main or LAD lesions, but 14 other patients with LAD lesions had septal excursions of 3 mm or greater. Nine of 16 patients with LAD lesions proximal to the first septal branch had reduced or absent septal excursion, as did three of ten with LAD lesions distal to the first septal branch. In a setting of coronary artery disease reduced or absent septal motion on echocardiography suggests involvement of the left main or left anterior descending coronary. However, the technique is relatively insensitive, with 54% of the LAD patients having normal septal motion.
Effect of continuing or finishing high-level sports on airway inflammation, bronchial hyperresponsiveness, and asthma: A 5-year prospective follow-up study of 42 highly trained swimmers
Authors: Ilkka Helenius, Paula Rytilä, Seppo Sarna, Aki Lumme, Miia Helenius, Ville Remes, Tari Haahtela
Journal: Journal of Allergy and Clinical Immunology (2002)
Defining trajectories of response in patients with psoriasis treated with biologic therapies
Authors: N. Geifman, N. Azadbakht, J. Zeng, T. Wilkinson, N. Dand, I. Buchan, D. Stocken, P. Di Meglio, R.B. Warren, J.N. Barker, N.J. Reynolds, M.R. Barnes, C.H. Smith, C.E.M. Griffiths, N. Peek
Journal: British Journal of Dermatology (2021)

The effectiveness and cost-effectiveness of biologic therapies for psoriasis are significantly compromised by variable treatment responses. Thus, more precise management of psoriasis is needed.To identify subgroups of patients with psoriasis treated with biologic therapies, based on changes in their disease activity over time, that may better inform patient management.We applied latent class mixed modelling to identify trajectory-based patient subgroups from longitudinal, routine clinical data on disease severity, as measured by the Psoriasis Area and Severity Index (PASI), from 3546 patients in the British Association of Dermatologists Biologics and Immunomodulators Register, as well as in an independent cohort of 2889 patients pooled across four clinical trials.We discovered four discrete classes of global response trajectories, each characterized in terms of time to response, size of effect and relapse. Each class was associated with differing clinical characteristics, e.g. body mass index, baseline PASI and prevalence of different manifestations. The results were verified in a second cohort of clinical trial participants, where similar trajectories following the initiation of biologic therapy were identified. Further, we found differential associations of the genetic marker HLA-C*06:02 between our registry-identified trajectories.These subgroups, defined by change in disease over time, may be indicative of distinct endotypes driven by different biological mechanisms and may help inform the management of patients with psoriasis. Future work will aim to further delineate these mechanisms by extensively characterizing the subgroups with additional molecular and pharmacological data.