tbuckley/cabot-search huggingface dataset:
BOOK REVIEWS
Authors: D. R. PARKINSON, M. SZNOL
Journal: JNCI Journal of the National Cancer Institute (1992)

BOOK REVIEWS Get access Biologic Therapy of Cancer V.T. Devita S. Hellman S.A. Rosenberg eds. Philadelphia : J.B. Lippincott 1991 . 800 pp., illus. $125 Principles of Cancer Biotherapy, 2nd Edition Robert K. Oldham ed. New York : Marcel Dekker , 1991 . 679 pp., illus.$135 DAVID R. PARKINSON, M.D., DAVID R. PARKINSON, M.D. Investigational Drug Branch Cancer Therapy Evaluation Program National Cancer Institute National Institutes of HealthExecutive Plaza N., Rm. 715 Bethesda, Rm. 715 Bethesda, MD 20892 Search for other works by this author on: Oxford Academic PubMed Google Scholar MARIO SZNOL, M.D. MARIO SZNOL, M.D. Investigational Drug Branch Cancer Therapy Evaluation Program National Cancer Institute National Institutes of HealthExecutive Plaza N., Rm. 715 Bethesda, Rm. 715 Bethesda, MD 20892 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 19, 7 October 1992, Pages 1527–1528, https://doi.org/10.1093/jnci/84.19.1527 Published: 07 October 1992
Correction to: Education to save lives: C19SPACE, the COVID19 Skills PrepAration CoursE
Authors: Stefan J. Schaller, Johannes Mellinghoff, Maurizio Cecconi, Cecconi Maurizio, Jozef Kesecioglu, Elie Azoulay, Lui Forni, Jean-Louis Teboul, Armand R. J. Girbes, Duska Frantisek, Adrian Wong, Jan De Waele, Johannes Mellinghoff, Giuseppe Citerio, Nicole Juffermans, Melania Istrate, Joel Alexandre, Stefan J. Schaller
Journal: Intensive Care Medicine (2022)
A randomized, controlled, phase 3 study of darolutamide in addition to androgen deprivation therapy (ADT) versus ADT alone in metastatic hormone-sensitive prostate cancer (ARANOTE).
Authors: Haresh KP, Egils Vjaters, Daniel Castellano, David Olmos, Neal D. Shore, Liina Nevalaita, Isabella Testa, Christian Kappeler, Iris Kuss, Fred Saad
Journal: Journal of Clinical Oncology (2022)

TPS200 Background: Previous randomized, phase 3 trials have shown the efficacy of adding docetaxel, abiraterone acetate, enzalutamide, or apalutamide to ADT in improving overall survival and/or radiologic progression-free survival (rPFS) in patients with metastatic hormone-sensitive prostate cancer (mHSPC). However, these combinations are associated with an increased risk of adverse events (eg, fatigue, rash, and cardiovascular events). Darolutamide is a structurally distinct and highly potent androgen receptor inhibitor. In the ARAMIS study, darolutamide has been shown to significantly reduce the risk of death by 31% and have a favorable safety profile in men with nonmetastatic castration-resistant prostate cancer. It has a low incidence of central nervous system−related adverse events, which may be explained by its distinct low blood−brain barrier penetration. Darolutamide has also been shown to have a low potential for drug−drug interactions, allowing flexibility with concomitant medications. ARANOTE will evaluate the efficacy and safety of darolutamide plus ADT in patients with mHSPC (NCT04736199). Methods: ARANOTE is an international, multicenter (ex-US), randomized, double-blind, placebo-controlled, phase 3 study in patients with histologically or cytologically confirmed adenocarcinoma of the prostate and documented metastatic disease by conventional imaging (eg, computed tomography or magnetic resonance imaging) who started ADT ≤12 weeks before randomization. In total, 555 patients will be randomized 2:1 to darolutamide 600 mg twice daily or placebo, plus ADT. Patients will be stratified by the presence of visceral metastases, assessed by central review, and prior local therapy. Patients will be evaluated every 12 weeks for efficacy, safety, and quality of life (using the FACT-P questionnaire) during treatment and active follow-up post treatment. For long-term follow-up, patients will be contacted by telephone every 12 weeks. The primary endpoint is rPFS; secondary endpoints include overall survival, time to castration-resistant prostate cancer, time to prostate-specific antigen progression, and safety. Recruitment is ongoing, and the first patient first visit was on February 23, 2021. The estimated study completion date is September 2025. Clinical trial information: NCT04736199.
Splenosis pleurae.
Authors: A G Jariwalla, N K Al-Nasiri
Journal: Thorax (1979)

<h3>Abstract</h3> Traumatic brain injury (TBI) is a serious condition, potentially causing seizures and other lifelong disabilities. Patients who experience at least one seizure one week after TBI (late seizure) are at high risk for lifelong complications of TBI, such as post-traumatic epilepsy (PTE). Identifying which TBI patients are at risk of developing seizures remains a challenge. Although magnetic resonance imaging (MRI) methods that probe structural and functional alterations after TBI are promising for biomarker detection, physical deformations following moderate-severe TBI present problems for standard processing of neuroimaging data, complicating the search for biomarkers. In this work, we consider a prediction task to identify which TBI patients will develop late seizures, using fractional anisotropy (FA) features from white matter tracts in diffusion-weighted MRI (dMRI). To understand how best to account for brain lesions and deformations, four preprocessing strategies are applied to dMRI, including the novel application of a lesion normalization technique to dMRI. The pipeline involving the lesion normalization technique provides the best prediction performance, with a mean accuracy of 0.819 and a mean area under the curve of 0.785. Finally, following statistical analyses of selected features, we recommend the dMRI alterations of a certain white matter tract as a potential biomarker.
An epidemic of acute toxoplasmosis
Authors: B. H. Kean
Journal: JAMA (1969)

An epidemic of acute lymphadenitic toxoplasmosis involved five medical students. Fever, headache, myalgia, lymphadenopathy, splenomegaly, and extremely high and rising Sabin-Feldman dye test and complement fixation titers characterized the illness. The students all ate rare hamburger at the same place, on the same night, and evidence indicates that this was the way in which the infections were acquired.
OUR POPULATION
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gonococcal Infection in the Male.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of calcium deposition on copper IUDs.
Authors: R Ikonen, Kirsti Maki
Journal: BMJ (1977)

Bacteriological cultures of human milk samples Growth of bacteria No of Per cent cases No growth .. .528 49 <10000/ml .. .408 38 10 000-20 000/ml 88 8 >20000ml ...51 5 Total .1075 100was put together and used without heating.The milk with growth less than 20 000 bacteria/ml was also pooled but used only after heating.Milk with growth of more than 20 000 bacteria/ml was discarded.We believe that the most important point in achieving "clean" milk is to give the mothers adequate instructions about how to collect and store their breast milk properly.This information can best be given at home if the milk is brought from there.The goal should be milk without bacteria.If growth of bacteria is found the reason must be discussed with the donor.When donors are informed that "clean" milk can be given to infants without harmful heating they really try and usually succeed in keeping their milk uncontaminated.According to our experience carefully collected breast milk can be kept in a refrigerator for at least three days without any growth of bacteria.So, depending on the way milk is collected and stored, pooled human milk can also be used without heating.The question to be answered, however, remains how much contaminated milk needs to be pasteurised and in what way.
Immunological control of ovarian carcinoma by chemotherapy and targeted anticancer agents
Authors: Jitka Fucikova, Lenka Palova-Jelinkova, Vanessa Klapp, Peter Holicek, Tereza Lanickova, Lenka Kasikova, Jana Drozenova, David Cibula, Beatriz Álvarez-Abril, Elena García-Martínez, Radek Spisek, Lorenzo Galluzzi
Journal: Trends in cancer (2022)
Recent progress in novel macrolides, quinolones, and 2‐pyridones to overcome bacterial resistance
Authors: Daniel T. W. Chu
Journal: Medicinal Research Reviews (1999)

Macrolides, such as clarithromycin and azithromycin, having good activity against pathogens such as Legionella, Chlamydia, Campylobacter spp, Branhamella spp, Pasteurella multocida and streptococci, have gained wide acceptance for the treatment of both upper and lower respiratory tracts, as well as cutaneous infections. Emergence of bacterial resistance, particularly in gram-positive bacteria, has been observed. Macrolide-resistant Streptococcus pneumoniae and S. pyogenes are found in France and many other countries, resulting in failure of therapy for pneumonia, pharyngitis, and skin infection. RU 004, HMR 3647, and TE 802 were reported to be active against these resistant strains. Research at Abbott produced several macrolide derivatives in the anhydrolide, tricyclic and tetracyclic ketolides as well as 6-O-alkyl ketolides series having potent activity against macrolide resistant S. pyogenes and S. pneumoniae . Research on streptogramins to overcome bacterial resistance in gram-positive bacteria has produced interesting compounds. Another class of antibacterial agent called quinolones is useful for the treatment of bacterial infections of respiratory tract, urinary tract, skin and soft tissues, as well as sexually transmitted diseases. Ciprofloxacin, the market leader, however, has low potency against anaerobes. Bacterial resistance ( such as Pseudomonas aeruginosa and methicillin- resistant Staphylococcus aureus ) to ciprofloxacin is increasing rapidly. Many quinolone compounds are being synthesized to address these drawbacks. The new quinolones currently under development are characterized by enhanced activities against streptococci, staphylococci, enterococci, and anaerobes. This presentation reviews the current research in the identification of agents to overcome the macrolide and quinolone resistance. © 1999 John Wiley & Sons, Inc. Med Res Rev, 19, No. 6, 497–520, 1999
TCTAP A-201 Impact of Simvastatin on Development of New-onset Diabetes Mellitus in Asian Population: Three-year Clinical Follow up Results
Authors: Yoonjee Park, Seung-Woon Rha, Byoung Geol Choi, Se Yeon Choi, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh
Journal: Journal of the American College of Cardiology (2014)
Facilitating prevention in primary care.
Authors: E Fullard, G Fowler, M Gray
Journal: BMJ (1984)

We believe that many general practitioners would practice preventive medicine if they had the opportunity to organise their practice to do this. We therefore provided a "facilitator," who understands the work of a general practice, to help practices that were interested in prevention to set up programmes. She, for example, helped the primary care team to set up objectives, trained practice nurses to measure blood pressure, and set up a system to measure the progress of the programme.
Physical Activity and Cardiovascular Health
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prescription ω-3 Therapy to Reduce Triglyceride Levels—A New Horizon for Cost-effective Therapy
Authors: Dariush Mozaffarian
Journal: JAMA Network Open (2022)

William S. Weintraub, MD; Deepak L. Bhatt, MD, MPH; Zugui Zhang, PhD; Sarahfaye Dolman, MPH; William E. Boden, MD; Adam P. Bress, PharmD, MS; Jordan B. King, PharmD, MS; Brandon K. Bellows, PharmD, MS; Gabriel S. Tajeu, DrPH, MPH; Catherine G. Derington, PharmD, MS; Jonathan Johnson, MS; Katherine Andrade, MPH; P. Gabriel Steg, MD; Michael Miller, MD; Eliot A. Brinton, MD; Terry A. Jacobson, MD; Jean-Claude Tardif, MD; Christie M. Ballantyne, MD; Paul Kolm, PhD
Animal Rabies—South Dakota, 1995
Journal: JAMA (1996)

On July 28, 1995, the South Dakota Public Health Laboratory diagnosed rabies in an 8-week-old puppy; on July 23, the puppy had had onset of neurologic signs (e.g., head tilt, ataxia, and somnolence) that culminated in seizures, and the puppy was euthanized. A clinically normal littermate owned by a neighboring family was euthanized on July 31 and tested positive for rabies. This report summarizes the epidemiologic investigation and follow-up management by the South Dakota Department of Health (SDDH), with assistance from CDC, of persons and domestic animals potentially exposed to rabies.
B.C.G. Vaccination
Authors: J. A. Young
Journal: BMJ (1948)

additional nursing staff is coming from.The best use must be made of our limited resources.Much can be achieved by the efficient organization of tuberculosis arrangements at both regional and hospital level.And it would help immediately and enormously if every large general hospital, both teaching and non-teaching, could be induced to open a male and a female tuberculosis ward.No big hospital can avoid having odd cases of phthisis passing through its wards.Better by far to nurse these in wards properly organized for the purpose and thus reduce the chances of infection of staff and possibly other patients.The training of nurses and of medical students would benefit, and the great increase in the total number of beds available for the disease would go far towards solving this grave problem.-I am, etc.,
How Sex and Gender Differences Relate to Medical Devices
Authors: Rita Rubin
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The radiotoxicology of Radithor. Analysis of an early case of iatrogenic poisoning by a radioactive patent medicine
Authors: R. M. Macklis
Journal: JAMA (1990)

Radithor was a radioactive patent medicine that was touted as a metabolic stimulant and aphrodisiac. We have obtained several original samples of Radithor and have used these historical specimens and a computer-based calculation model to perform a retrospective analysis of a famous case of Radithorrelated radium poisoning. Our data suggest that the victim's cumulative skeletal radiation dose may have exceeded 350 Sv by the time he died. This figure far exceeds most current estimates of what radiation exposure level would constitute a rapidly lethal dose if given acutely. The physiological response to long-term internal radiation exposure and the highly localized nature of alpha particle irradiation may require the development of new models for the assessment of risk in cases of internal alpha particle irradiation. (<i>JAMA.</i>1990;264:619-621)
Call for consensus in Chlamydia trachomatis nomenclature: moving from biovars, serovars, and serotypes to genovariants and genotypes
Authors: Henry J.C. de Vries, Yvonne Pannekoek, Debora Dean, Patrick M. Bavoil, Nicole Borel, Gilbert Greub, Servaas A. Morré
Journal: Clinical Microbiology and Infection (2022)
Impact of neoadjuvant immune checkpoint inhibitor therapy on primary tumor size and complexity: Correlation with surgical quality and short term oncological outcomes.
Authors: Ava Saidian, Kevin Hakimi, Justine Panian, Archana Ajmera, Pedro C. Barata, Stephanie A. Berg, Steven Lee Chang, Toni K. Choueiri, Hannah Elizabeth Dzimitrowicz, Hamid Emamekhoo, Evan Gross, Deepak Kilari, Elaine Tat Lam, Taylor Nonato, Sarah P. Psutka, Bicky Thapa, Nicole Weise, Tian Zhang, Rana R. McKay, Ithaar Derweesh
Journal: Journal of Clinical Oncology (2022)

390 Background:The concept of primary systemic therapy has gained increasing traction in the management of metastatic and locally advanced Renal Cell Carcinoma (RCC). Most series have evaluated the use of tyrosine-kinase inhibitors, however, with the emergence of immune checkpoint inhibitor therapy as first line agents in advanced RCC, further assessment of efficacy is warranted. We examined the effects of immunotherapy (IO) combinations on the primary tumor and consequent surgical quality and short-term oncological outcomes. Methods: We conducted a multi-center, retrospective analysis of patients with advanced/metastatic RCC having received IO followed by Radical (RN) or partial nephrectomy (PN). Primary outcome was achievement of Bifecta (composite outcome of complete resection and no 30-day post-operative complications). Predictors for achievement of Bifecta were assessed with logistic regression multivariable analysis. Secondary outcomes were change in maximal tumor dimension, RENAL nephrometry score and disease progression. Kaplan-Meier analysis was used to assess progression-free survival (PFS) for Bifecta and non-Bifecta patients. Results: We identified 52 patients with advanced RCC across 9 institutions who were eligible. The median age was 63 years and 60.4% were males. Median tumor size at diagnosis was 9.3 cm. 19.6% had T4 disease and 75% had AJCC Stage IV disease. IO treatment resulted in significant reductions in median tumor size (-25.4%; 9.7 cm vs. 7.3cm p = 0.0129) and RENAL nephrometry score (9 to 8, p = 0.032). 43 (83%) of patients underwent RN and (9) 17% had PN. Median tumor size was smaller for PN (8 vs. 4.1 cm, p &lt; 0.001), and 30 day complication rates were higher (p = 0.024). Bifecta was achieved in 39 patients [33/42 (78.6%) RN and 6/9 (67%) PN, p = 0.264). Predictors for achievement of Bifecta were younger age (OR 1.06, p = 0.01), increasing reduction in tumor size (OR 1.187, p &lt; 0.001), and shorter time between therapy and surgery (OR 1.07, p &lt; 0.001). Kaplan-Meier analysis demonstrated longer median time to progression in the Bifecta-positive group compared to patients who failed to achieve Bifecta (75 vs. 30 months, p = 0.04). Conclusions: Pre-surgical therapy resulted in tumor size and complexity reduction. Tumor size reduction was predictive for achievement of Bifecta, which was associated with improved short term oncological outcomes. To our knowledge, this is the first series evaluating the effect of neoadjuvant systemic therapy on the primary tumor prior to surgical intervention.
Familial concentration of ischaemic heart disease.
Journal: BMJ (1967)

MEDBCAL JOURNAIconditions in Belfast, Alexandria, and Bombay, where the incidence of defects of the neural tube is high, might be well worth while.The effects of the high consanguinity and twinning rates in Alexandria would also repay further investi- gation.Two other large centres which are considered to be worth special study are Mexico City, where maternal diabetes seems to be unusually prevalent, and Singapore, because of the ethnic diversity of its inhabitants.But even without these developments this work will be well received everywhere as a welcome example of international co-operation in epidemio- logical research.