Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk
Authors: Bonnie F. Liebman, Martijn B. Katan, Michael F. Jacobson
Journal: Annals of Internal Medicine (2014)

Letters16 September 2014Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary RiskBonnie F. Liebman, MS, Martijn B. Katan, PhD, and Michael F. Jacobson, PhDBonnie F. Liebman, MSFrom Center for Science in the Public Interest, Washington, DC; VU University Amsterdam, Amsterdam, the Netherlands; and Center for Science in the Public Interest, Washington, DC.Search for more papers by this author, Martijn B. Katan, PhDFrom Center for Science in the Public Interest, Washington, DC; VU University Amsterdam, Amsterdam, the Netherlands; and Center for Science in the Public Interest, Washington, DC.Search for more papers by this author, and Michael F. Jacobson, PhDFrom Center for Science in the Public Interest, Washington, DC; VU University Amsterdam, Amsterdam, the Netherlands; and Center for Science in the Public Interest, Washington, DC.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L14-5018-4 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Chowdhury and colleagues (1) concluded that evidence is insufficient to support guidelines that encourage high intake of PUFAs and low intake of SFAs by misrepresenting the strongest evidence for those guidelines.An earlier meta-analysis (2) found a 19% reduction in CHD risk in RCTs that replaced saturated fat with ω-6 PUFAs. In their Supplement Figure 14, Chowdhury and colleagues found no significant risk reduction because they included 1 additional trial, the SDHS, which provided participants with margarine high in trans fatty acids. Without the SDHS, Chowdhury and colleagues found the same 19% risk reduction. Was that critical ...References1. Chowdhury R, Warnakula S, Kunutsor S, Crowe F, Ward HA, Johnson L, et al. Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis. Ann Intern Med. 2014;160:398-406. [PMID: 24723079] doi:10.7326/M13-1788 LinkGoogle Scholar2. Mozaffarian D, Micha R, Wallace S. Effects on coronary heart disease of increasing polyunsaturated fat in place of saturated fat: a systematic review and meta-analysis of randomized controlled trials. PLoS Med. 2010;7:e1000252. [PMID: 20351774] doi:10.1371/journal.pmed.1000252 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Center for Science in the Public Interest, Washington, DC; VU University Amsterdam, Amsterdam, the Netherlands; and Center for Science in the Public Interest, Washington, DC.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L14-0320. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAssociation of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Rajiv Chowdhury , Samantha Warnakula , Setor Kunutsor , Francesca Crowe , Heather A. Ward , Laura Johnson , Oscar H. Franco , Adam S. Butterworth , Nita G. Forouhi , Simon G. Thompson , Kay-Tee Khaw , Dariush Mozaffarian , John Danesh , and Emanuele Di Angelantonio Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Rajiv Chowdhury , Samantha Warnakula , Setor Kunutsor , Francesca Crowe , Heather A. Ward , Laura Johnson , Oscar H. Franco , Adam S. Butterworth , Nita G. Forouhi , Simon G. Thompson , Kay-Tee Khaw , Dariush Mozaffarian , John Danesh , and Emanuele Di Angelantonio Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Christine Dawczynski , Marcus E. Kleber , Winfried März , Gerhard Jahreis , and Stefan Lorkowski Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Frank Davidoff and Irwin H. Rosenberg Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Lisa Te Morenga , Jim Mann , and Murray Skeaff Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Lukas Schwingshackl and Georg Hoffmann Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Mark McCaulley Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Connie Diekman , Gerard Hornstra , Bethold V. Koletzko , Anna Lartey , and Joyce Nettleton Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Johanna M. Geleijnse , Ingeborg A. Brouwer , and Daan Kromhout Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Adrienne O’Neil and Catherine Itsiopoulos Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Emanuele Di Angelantonio , Rajiv Chowdhury , Nita G. Forouhi , and John Danesh Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Adrienne O’Neil and Catherine Itsiopoulos Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Walter C. Willett , Meir J. Stampfer , and Frank M. Sacks Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Emanuele Di Angelantonio , Rajiv Chowdhury , Nita G. Forouhi , and John Danesh Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Frank Davidoff and Irwin H. Rosenberg Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Christine Dawczynski , Marcus E. Kleber , Winfried März , Gerhard Jahreis , and Stefan Lorkowski Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Johanna M. Geleijnse , Ingeborg A. Brouwer , and Daan Kromhout Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Mark McCaulley Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Lisa Te Morenga , Jim Mann , and Murray Skeaff Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Lukas Schwingshackl and Georg Hoffmann Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Connie Diekman , Gerard Hornstra , Bethold V. Koletzko , Anna Lartey , and Joyce Nettleton Metrics Cited ByPathways and mechanisms linking dietary components to cardiometabolic disease: thinking beyond caloriesSaturated Fats Versus Polyunsaturated Fats Versus Carbohydrates for Cardiovascular Disease Prevention and TreatmentNew Insights or Confusion—Is Butter Really Back? 16 September 2014Volume 161, Issue 6Page: 454-455KeywordsCardiovascular therapyDisclosureFatsFatty acids ePublished: 16 September 2014 Issue Published: 16 September 2014 CopyrightCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...