tbuckley/cabot-search huggingface dataset:
CAN ROUTINE BIOPSY OF COLORECTAL ENDOSCOPIC MUCOSAL RESECTION SCARS BE ABANDONED? – PRELIMINARY DATA OF A MULTICENTRE RANDOMIZED SINGLE-BLINDED CROSSOVER TRIAL
Authors: M. João, T. Pinto Pais, M. Areia, S. Alves, D. Brito, L. Elvas, S. Saraiva, M. Dinis Ribeiro, A.T. Cadime
Journal: Endoscopy (2022)

Aims Current ESGE guideline suggests that routine biopsy of endoscopic mucosal resection (EMR) scars can be abandoned provided that a standardized imaging protocol with virtual chromoendoscopy is used. However, few studies have examined the accuracy of advanced endoscopic imaging for the prediction of histological recurrence. We aimed to assess the incremental benefit of narrow band imaging (NBI) versus white light endoscopy (WLE) by randomizing the initial technique for the endoscopic detection of post-EMR recurrence and to assess if NBI achieves a diagnostic accuracy that replaces the need for biopsy.
ABSENCE OF CHOLEDOCHUS: AN EXCEPTIONAL ABNORMALY OF THE BILIARY TRACT
Authors: N. Torres Monclús, E. Pijoan Comas, I. Miguel Salas, G. Torres Vicente, D. Bayas Pastor, D. Vazquez Gomez, N. Zaragoza Velasco, F. Gonzalez-Huix Llado
Journal: Endoscopy (2022)

Results 77-year-old patient with acute cholangitis. In the imaging study, a variant of normality is detected: right and left hepatic ducts converge at the distal intrapancreatic level with the consequent absence of a common hepatic duct. Likewise, the cystic duct has a very low implantation, in the same region of confluence. A 5mm stone was observed in the cystic duct and another in the duct confluence area. ERCP was performed with removal of the impacted stone at the suprapapillary level. On injecting contrast, cystic and what appears to be choledochus, repleniced. Contrast reflux into a third duct, suspecting a malformation of the choledochus insertion. It was not possible to extract the lithiasis located in cystic, so a double pigtail plastic stent was placed in the gallbladder. He was readmitted for a new episode of cholangitis. A second ERCP is performed: spontaneous migration of the cystic stent. At 7-8mm from the papilla, confluence of right and left hepatic ducts was observed that cross between them: the right goes to the left and the left goes to the right, with the absence of common bile ducts and choledochus. Cystic with obstructive lithiasis implanted about 5-6 mm from the bifurcation in the left hepatic duct.
Safety and efficacy of ganaxolone in patients with CDKL5 deficiency disorder: results from the double-blind phase of a randomised, placebo-controlled, phase 3 trial
Authors: Elia M Pestana Knight, Sam Amin, Nadia Bahi-Buisson, Tim A Benke, J Helen Cross, Scott T Demarest, Heather E Olson, Nicola Specchio, Thomas R Fleming, Alex A Aimetti, Maciej Gasior, Orrin Devinsky
Journal: The Lancet Neurology (2022)
ADDED VALUE OF SECRETIN DURING MAGNETIC RESONANCE IMAGING TO IDENTIFY DUCTAL COMMUNICATION IN PANCREATIC CYSTIC NEOPLASMS (IMAGE-S): PROSPECTIVE STUDY
Authors: M. Gorris, N. van Huijgevoort, M. Besselink, F. Struik, M. Engelbrecht, J. van Hooft
Journal: Endoscopy (2022)

Aims The key feature of side-branch intraductal papillary mucinous neoplasms (SB-IPMN) is its connection with the pancreatic ductal system. This feature could be helpful to distinguish potentially premalignant SB-IPMN from benign lesions. This study aimed to investigate if secretin-enhanced magnetic resonance cholangiopancreatography (s-MRCP) improved visualization of ductal connection in PCN.
MRI PRIOR TO PRECISE ENDOSCOPIC EVALUATION OF RECTAL LESIONS MAY LEAD TO UNNECESSARY RADICAL TREATMENT
Authors: D. Osuská, B. Pekárek, A. Orságh, J. Letkovský, Ľ. Žitňan, B. Kunčak
Journal: Endoscopy (2022)

Aims Proper preprocedural staging of rectal lesions is crucial for the patient’s future outcomes and quality of life. Early rectal tumors with a depth of neoplastic invasion up to stage T1 may be curatively treated endoscopically; deeper tumors require more invasive treatment. Endoscopic assessment of the depth of neoplastic invasion is often challenging and occasionally additional radiological imaging is used. The aim of this work was to assess the accuracy of pelvic magnetic resonance imaging (MRI) to distinguish stages T0/TIS-T1, where curative endoscopic resection is possible, from stages T2-T4, in the preoperative staging of rectal neoplasia.
21P Metabolomic profiling and response to neoadjuvant therapy in operable breast cancer
Authors: A. Gennari, V. Martini, R. Boldorini, C. Saggia, V. Rossi, F. D'Avanzo, I. Dodaro, E. Gallarotti, A. Rua, C. Branni, A. Stella, A. Tassone, E. Gioffi, P. Maggiora, A. Gambaro, A. Rampi, A. Sica, S. Khoso, E. Barberis, M. Manfredi
Journal: Annals of Oncology (2022)
ARTIFICIAL INTELLIGENCE FOR REAL-TIME OPTICAL DIAGNOSIS OF NEOPLASTIC POLYPS DURING COLONOSCOPY
Authors: I. Barua, P. Wieszczy, S.-e. Kudo, M. Misawa, Ø. Holme, S. Gulati, S. Williams, K. Mori, H. Itoh, K. Takishima, K. Mochizuki, Y. Miyata, K. Mochida, Y. Akimoto, T. Kuroki, Y. Morita, O. Shiina, S. Kato, T. Nemoto, B. Hayee, M. Patel, N. Gunasingam, A. Kent, A. Emmanuel, C. Munck, J.A. Nilsen, S. Astrup Hvattum, S.O. Frigstad, P. Tandberg, M. Løberg, M. Kalager, A. Haji, M. Bretthauer, Y. Mori
Journal: Endoscopy (2022)

Aims Artificial intelligence using computer-aided diagnosis (CADx) may enable colonoscopists to distinguish between neoplastic polyps requiring removal and non-neoplastic polyps not requiring removal during colonoscopy. This may reduce costs and resources and prevent polyp overtreatment in colorectal cancer screening.
ENDOSCOPIC PANCREATIC SPHINCTEROTOMY IN PATIENTS WITH IPMN-RELATED RECURRENT PANCREATITIS: A SINGLE CENTER EXPERIENCE
Authors: T. Schepis, A. Tringali, F. D'Aversa, E.C. Nista, P. Familiari, I. Boskoski, V. Perri, G. Costamagna
Journal: Endoscopy (2022)

Aims Intraductal Papillary Mucinous Neoplasms (IPMNs) are a mucin producing subtype of pancreatic cysts arising from the pancreatic duct system. The tick mucous produced by IPMNs can cause an obstruction of the main pancreatic duct leading to recurrent acute pancreatitis (RAP). Endoscopic pancreatic sphincterotomy (EPS) can reduce the frequency of RAP. The aim of this study is to assess the safety and effectiveness of EPS in reducing the episodes of RAP in patients with IPMNs related RAP.
SUCCESSFUL ENDOSCOPIC MANAGEMENT OF A SLEEVE GASTRECTOMY LEAK UTILIZING LUMINAL STENTING, PNEUMATIC DILATIONS, ABSCESS DRAINAGE AND SEPTOTOMY
Authors: M. Lajin
Journal: Endoscopy (2022)

Day 23: Stents removal, pneumatic dilation to an angulation at the incisura, abscess lavage/drainage with 2 transgastric double pigtail stents, and placement of a nasoduodenal feeding tube.
Improving polygenic prediction in ancestrally diverse populations
Authors: Yunfeng Ruan, Yen-Feng Lin, Yen-Chen Anne Feng, Chia-Yen Chen, Max Lam, Zhenglin Guo, Yong Min Ahn, Kazufumi Akiyama, Makoto Arai, Ji Hyun Baek, Wei J. Chen, Young-Chul Chung, Gang Feng, Kumiko Fujii, Stephen J. Glatt, Kyooseob Ha, Kotaro Hattori, Teruhiko Higuchi, Akitoyo Hishimoto, Kyung Sue Hong, Yasue Horiuchi, Hai-Gwo Hwu, Masashi Ikeda, Sayuri Ishiwata, Masanari Itokawa, Nakao Iwata, Eun-Jeong Joo, Rene S. Kahn, Sung-Wan Kim, Se Joo Kim, Se Hyun Kim, Makoto Kinoshita, Hiroshi Kunugi, Agung Kusumawardhani, Jimmy Lee, Byung Dae Lee, Heon-Jeong Lee, Jianjun Liu, Ruize Liu, Xiancang Ma, Woojae Myung, Shusuke Numata, Tetsuro Ohmori, Ikuo Otsuka, Yuji Ozeki, Sibylle G. Schwab, Wenzhao Shi, Kazutaka Shimoda, Kang Sim, Ichiro Sora, Jinsong Tang, Tomoko Toyota, Ming Tsuang, Dieter B. Wildenauer, Hong-Hee Won, Takeo Yoshikawa, Alice Zheng, Feng Zhu, Lin He, Akira Sawa, Alicia R. Martin, Shengying Qin, Hailiang Huang, Tian Ge
Journal: Nature Genetics (2022)
LONG TERM OUTCOME OF GASTROINTESTINAL ENDOSCOPIC RESECTION IN PATIENTS WITH LIVER CIRRHOSIS
Authors: S.H. Kim, D.H. Kim, S.-Y. Park, H.S. You, S.Y. Cho, J.H. Yoon, C.H. Park, H.S. Kim, S.K. Choi
Journal: Endoscopy (2022)

Aims Endoscopic resection has developed over the years. The main complications are perforation and bleeding. This study aimed to evaluate safety and effectiveness of digestive endoscopic resection in patients with cirrhosis
ENDOSCOPIC SUBMUCOSAL DISSECTION (ESD) VERSUS PIECE-MEAL ENDOSCOPIC MUCOSAL RESECTION (EMR) FOR LARGE LATERALLY SPREADING LESIONS (LSL): FRENCH RANDOMIZED CONTROLLED TRIAL (RESECT-COLON)
Authors: J. Jacques, T. Wallenhorst, J.-B. Chevaux, V. Lepilliez, S. Chaussade, J. Rivory, R. Legros, M. Schaefer, S. Leblanc, F. Rostain, M. Barret, J. Albouys, A. Belle, S. Crepin, J. Magne, P.M. Preux, H. Lepetit, M. Dahan, T. Ponchon, M. Pioche
Journal: Endoscopy (2022)

Aims The optimal endoscopic resection strategy for large LSL is debated between Japanese (ESD) and western (PM-EMR) attitudes. No randomized trial is available about this daily topic.
NURSE-LED ENDOSCOPIC TRIAGE OF THE SUSPECTED UPPER GASTROINTESTINAL CANCER REFERRALS DURING THE COVID-19 PANDEMIC
Authors: M.G. Shiha, L. Alleyne, L. Wookey
Journal: Endoscopy (2022)

Aims The COVID-19 pandemic had a profound negative impact on endoscopic services and capacity leading to concerns regarding delayed cancer diagnosis. We aimed to assess the efficacy and outcomes of nurse-led endoscopic telephone triage of suspected upper gastrointestinal (UGI) cancer referrals.
Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management
Authors: Hedi L Claahsen - van der Grinten, Phyllis W Speiser, S Faisal Ahmed, Wiebke Arlt, Richard J Auchus, Henrik Falhammar, Christa E Flück, Leonardo Guasti, Angela Huebner, Barbara B M Kortmann, Nils Krone, Deborah P Merke, Walter L Miller, Anna Nordenström, Nicole Reisch, David E Sandberg, Nike M M L Stikkelbroeck, Philippe Touraine, Agustini Utari, Stefan A Wudy, Perrin C White
Journal: Endocrine Reviews (2021)

Abstract Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders affecting cortisol biosynthesis. Reduced activity of an enzyme required for cortisol production leads to chronic overstimulation of the adrenal cortex and accumulation of precursors proximal to the blocked enzymatic step. The most common form of CAH is caused by steroid 21-hydroxylase deficiency due to mutations in CYP21A2. Since the last publication summarizing CAH in Endocrine Reviews in 2000, there have been numerous new developments. These include more detailed understanding of steroidogenic pathways, refinements in neonatal screening, improved diagnostic measurements utilizing chromatography and mass spectrometry coupled with steroid profiling, and improved genotyping methods. Clinical trials of alternative medications and modes of delivery have been recently completed or are under way. Genetic and cell-based treatments are being explored. A large body of data concerning long-term outcomes in patients affected by CAH, including psychosexual well-being, has been enhanced by the establishment of disease registries. This review provides the reader with current insights in CAH with special attention to these new developments.
CLOSE THE HOLE AND BACK ON TRACK
Authors: G. Bastens, O. Plomteux, B. Feytmans, Y. Lamani, A.-C. Dandrifosse, R. Bisschops, P. Leclercq
Journal: Endoscopy (2022)

We report the videocase of a refractory and delayed esophageal ulcer healing after endoscopic submucosal dissection of an early esophageal adenocarcinoma developed on a C10M10 Barrett’s esophagus in a patient with previous history of Roux-en-Y gastric bypass.Gastro-gastric fistula related to gastric minimizer was found to be responsible for PPI refractory GERD. Endoscopic closure of the gastro-gastric fistula allowed healing of the post-ESD esophageal ulcer. This endoscopic treatment allowed the patient to proceed to the next step of the Barrett’s esophagus endoscopic treatment (by radiofrequency ablation).
Comparison of the phenotypic characteristics between responders and non-responders to obstructive sleep apnea treatment using mandibular advancement devices in adult patients: Systematic review and meta-analysis
Authors: Sara Camañes-Gonzalvo, Carlos Bellot-Arcís, Rocío Marco-Pitarch, Jose M. Montiel-Company, Marina García-Selva, Rubén Agustín-Panadero, Vanessa Paredes-Gallardo, Francisco J. Puertas-Cuesta
Journal: Sleep Medicine Reviews (2022)

Mandibular advancement device (MAD) therapy is the most commonly used second-line treatment for obstructive sleep apnea (OSA), but MAD may be ineffective in a subgroup of patients. The aim of this systematic review is to identify predictors of the efficacy of oral appliance (OA) therapy for OSA in adult patients. This review focuses on performing the quantitative analysis by subgroups based on the response criteria used in the literature and based on the type of device. PubMed, EMBASE, Scopus, Web of Science and Cochrane databases was conducted to identify potentially relevant studies published until Dec 2021. The search identified 1343 preliminary references. A total of 99 studies met the eligibility criteria and were included in the review, and 60 in the meta-analysis. The quality of studies was assessed using the Newcastle–Ottawa scale and the Cochrane scale. Based on meta-analysis, and considering a low to moderate evidence profile according to the GRADE scale, responders are younger patients, with smaller neck circumference, lower body mass index. Responders have shorter maxillary length, lower anterior and posterior facial height, a shorter distance from the hyoid bone to the third cervical vertebra, a shorter airway length, a smaller minimum airway cross-sectional area and a higher minimum oxygen saturation during sleep. Responders needed a lower optimal continuous positive airway pressure than non-responders. The type of device has not affected the results of the meta-analysis. The criterion "AHI <10 and reduction AHI >50%" is the one that provides the "weight" of significance for several variables. This criterion should be taken into consideration for future studies to predict OSA treatment by OA.
SCREENING FOR HEAD AND NECK TUMOURS IN PATIENTS WITH OESOPHAGEAL SQUAMOUS CELL CARCINOMA AND VICE VERSA: A NATIONWIDE SURVEY AMONG MEDICAL SPECIALISTS
Authors: L. van Tilburg, S.A. van den Ban, S.E. van de Ven, A. Sewnaik, M.J. Bruno, M.C. Spaander, R.J. Baatenburg de Jong, A.D. Koch
Journal: Endoscopy (2022)

Aims In retrospective studies, minimally 5% of oesophageal (ESCC) and 11% of head and neck squamous cell carcinoma (HNSCC) patients in Western countries developed a second primary tumour (SPT). This study aimed to assess the knowledge and opinions regarding screening for head and neck SPTs (HNSPTs) in ESCC patients and oesophageal SPTs (ESPTs) in HNSCC patients in the Netherlands.
ACETIC ACID WITH NBI/BLI FOR PIT PATTERN DIAGNOSIS OF THE COLORECTAL POLYPS
Authors: S. Yamamoto, H. Ishida, E. Mita
Journal: Endoscopy (2022)

Aims Kudo's pit pattern classification has been used for endoscopic evaluation of colorectal polyps. Our aim is to analyze the feasibility of acetic acid together with NBI or BLI (aceto-electrical chromoendoscopy; AEC) for inspecting the pit pattern.
REVIEW OF A SINGLE MONTH OF COLONOSCOPIES IN A SECONDARY HOSPITAL IN THE EAST OF IRELAND
Authors: C. Kinsella, S. Kahn, N. O'Donovan, C. Ryan
Journal: Endoscopy (2022)

Methods A retrospective study of 100 colonoscopies was performed. Patients were identified through HIPE records. Endorad was then employed to review reports and collect the data.
INTEREST OF COLONOSCOPY IN PATIENTS WITH CONSTIPATION: A COMPARATIVE STUDY ACCORDING TO AGE
Authors: A. Sair, A. Benhamdane, T. Addajou, M. Osman, S. Mrabti, R. Berraida, S. Sentissi, I. Elkoti, F. Rouibaa, A. Benkirane, H. Seddik
Journal: Endoscopy (2022)

Aims Constipation is probably the most common digestive symptom. It may be the expression of an organic or functional pathology. The etiologies are multiple and must be eliminated.The aim of our study is to evaluate the interest of colonoscopy in the exploration of constipation according to the age of the patient.
Nanomaterials in cancer: Reviewing the combination of hyperthermia and triggered chemotherapy
Authors: Tiago P. Ribeiro, J. Agostinho Moreira, Fernando J. Monteiro, Marta S. Laranjeira
Journal: Journal of Controlled Release (2022)

Nanoparticle mediated hyperthermia has been explored as a method to increase cancer treatment efficacy by heating tumours inside-out. With that purpose, nanoparticles have been designed and their properties tailored to respond to external stimuli and convert the supplied energy into heat, therefore inducing damage to tumour cells. Moreover, the combination of hyperthermia with chemotherapy has been described as a more effective strategy due to the synergy between the high temperature and the drug's effects, also associated with a remote controlled and on-demand drug release. In this review, the methods behind nanoparticle mediated hyperthermia, namely material design, external stimuli response and energy conversion will be discussed and critically analysed. We will address the most relevant studies on hyperthermia and temperature triggered drug release for cancer treatment. Finally, the advantages, difficulties and challenges of this therapeutic strategy will be discussed, while giving insight for future developments.
MUCINOUS CYSTADENOMA INFECTION AFTER EUS AND MORAY MICROFORCEPS BIOPSIES
Authors: E. Pijoan Comas, A. Vargas García, N. Torres Monclús, D.C. Bayas Pástor, I. Miguel Salas, M. Alburquerque Miranda, G. Torres Vicente, N. Zaragoza Velasco, M. Figa Francesch, F. Gonzalez-Huix Lladó
Journal: Endoscopy (2022)

A 74-year-old woman underwent EUS for pancreatic isthmus cyst with increasing size (up to 62x54mm). Punction with cytologic 16G needle was performed, obtaining liquid and biopsies of the cystic wall with Moray microforceps (5 bites). Mucinous cystadenoma with low grade dysplasia was diagnosed.
Adenovirus type 5 SARS-CoV-2 vaccines delivered orally or intranasally reduced disease severity and transmission in a hamster model
Authors: Stephanie N. Langel, Susan Johnson, Clarissa I. Martinez, Sarah N. Tedjakusuma, Nadine Peinovich, Emery G. Dora, Philip J. Kuehl, Hammad Irshad, Edward G. Barrett, Adam D. Werts, Sean N. Tucker
Journal: Science Translational Medicine (2022)

Transmission-blocking strategies that slow the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and protect against coronavirus disease 2019 (COVID-19) are needed. We have developed an orally delivered adenovirus type 5-vectored SARS-CoV-2 vaccine candidate that expresses the spike protein. Here, we demonstrated that hamsters vaccinated by the oral or intranasal route had robust and cross-reactive antibody responses. We then induced a postvaccination infection by inoculating vaccinated hamsters with SARS-CoV-2. Orally or intranasally vaccinated hamsters had decreased viral RNA and infectious virus in the nose and lungs and experienced less lung pathology compared to mock-vaccinated hamsters after SARS-CoV-2 challenge. Naïve hamsters exposed in a unidirectional air flow chamber to mucosally vaccinated, SARS-CoV-2-infected hamsters also had lower nasal swab viral RNA and exhibited fewer clinical symptoms than control animals, suggesting that the mucosal route reduced viral transmission. The same platform encoding the SARS-CoV-2 spike and nucleocapsid proteins elicited mucosal cross-reactive SARS-CoV-2-specific IgA responses in a phase 1 clinical trial (NCT04563702). Our data demonstrate that mucosal immunization is a viable strategy to decrease SARS-CoV-2 disease and airborne transmission.
Association of Task-Shared Psychological Interventions With Depression Outcomes in Low- and Middle-Income Countries
Authors: Eirini Karyotaki, Ricardo Araya, Ronald C. Kessler, Ahmed Waqas, Arvin Bhana, Atif Rahman, Camila T. Matsuzaka, Clara Miguel, Crick Lund, Emily C. Garman, Etheldreda Nakimuli-Mpungu, Inge Petersen, John A. Naslund, Marguerite Schneider, Siham Sikander, Mark J. D. Jordans, Melanie Abas, Pauline Slade, Stephen Walters, Traolach S. Brugha, Toshi A. Furukawa, Yagmur Amanvermez, Marcelo F. Mello, Milton L. Wainberg, Pim Cuijpers, Vikram Patel
Journal: JAMA Psychiatry (2022)

Task sharing, the training of nonspecialist workers with no formal experience in counseling, is a promising strategy for addressing the large gap in treatment for depression in low- and middle-income countries (LMICs).
PRD-Class Homeobox Genes in Bovine Early Embryos: Function, Evolution, and Overlapping Roles
Authors: Thomas D. Lewin, Ali A. Fouladi-Nashta, Peter W.H. Holland
Journal: Molecular Biology and Evolution (2022)

Eutherian Totipotent Cell Homeobox (ETCHbox) genes are mammalian-specific PRD-class homeobox genes with conserved expression in the preimplantation embryo but fast-evolving and highly divergent sequences. Here, we exploit an ectopic expression approach to examine the role of bovine ETCHbox genes and show that ARGFX and LEUTX homeodomain proteins upregulate genes normally expressed in the blastocyst; the identities of the regulated genes suggest that, in vivo, the ETCHbox genes play a role in coordinating the physical formation of the blastocyst structure. Both genes also downregulate genes expressed earlier during development and genes associated with an undifferentiated cell state, possibly via the JAK/STAT pathway. We find evidence that bovine ARGFX and LEUTX have overlapping functions, in contrast to their antagonistic roles in humans. Finally, we characterize a mutant bovine ARGFX allele which eliminates the homeodomain and show that homozygous mutants are viable. These data support the hypothesis of functional overlap between ETCHbox genes within a species, roles for ETCHbox genes in blastocyst formation and the change of their functions over evolutionary time.
Hair follicle-targeting drug delivery strategies for the management of hair follicle-associated disorders
Authors: Yueting Gu, Qiong Bian, Yanjun Zhou, Qiaoling Huang, Jianqing Gao
Journal: Asian Journal of Pharmaceutical Sciences (2022)

The hair follicle is not only a critical penetration route in percutaneous absorption but also has been recognized to be a target for hair follicle-associated disorders, such as androgenetic alopecia (AGA) and acne vulgaris. Hair follicle-targeting drug delivery systems allow for controlled drug release and enhance therapeutic efficacy with minimal side effects, exerting a promising method for the management of hair follicle-associated dysfunctions. Therefore, they have obtained much attention in several fields of research in recent years. This review gives an overview of potential follicle-targeting drug delivery formulations currently applied based on the particularities of the hair follicles, including a comprehensive assessment of their preclinical and clinical performance.
PROTEIN KINASE B AS A PREDICTOR OFMETASTATIC GASTRIC ADENOCARCINOMA
Authors: R. Dardor, S. Abd El Moniem, H. Shabana, M. Elbaiomy, N. Megahed
Journal: Endoscopy (2022)

Methods Enrolled Patients were divided into 2 groups, group (1) included 23 patients with metastatic gastric adenocarcinoma and group (2) included 10 patients with non metastatic disease. Liver and renal biochemical tests, CBC, H. pylori testing ,CEA , CA19-9 & metastatic radiological work up were done. Histopathologic examination and immunohistochemistry staining of samples from gastric adenocarcinoma obtained through upper GI endoscopy were done. Immunohistochemistry score for the expression of PI3K, AKT (protein kinase B) & mTOR (ranging from 0 to 12) was calculated as follows: grade of stain intensity×grade of coloration rate. A score≥4 was considered positive.
VALIDATION OF REAL-TIME CAD SYSTEM FOR COLORECTAL POLYP DETECTION AND CHARACTERIZATION DURING COLONOSCOPY IN CROATIAN COHORT OF PATIENTS – PRELIMINARY DATA
Authors: R. Prijic, K. Grubelic Ravic, I. Huml, I. Skrlec, Z. Krznaric
Journal: Endoscopy (2022)

Aims From January to February 2021 real-time computer-aided diagnosis (CAD) system (FujiFilm CAD Eye) for polyp detection (CADe) and characterization (CADx) was used in an out-patient clinic for colonoscopy procedures for validation in Croatian cohort of patients. This system works with integrated image enhancement technologies for supporting detection and characterization.