tbuckley/cabot-search huggingface dataset:
Zero Childhood Cancer: A comprehensive precision medicine platform for children with high-risk cancer in Australia
Authors: Michelle Haber, Mark J Cowley, Paul Ekert, Loretta Lau, Emily Mould, Andrew Gifford, Richard B Lock, Glenn M Marshall, Murray D Norris, Tracey O'Brien, Anh Khuong Quang Dong, David Thomas, Toby Trahair, Katherine Tucker, David S Ziegler, Vanessa Tyrrell
Journal: Cancer Research (2020)
Hepatocyte SH3RF2 Deficiency Is a Key Aggravator for NAFLD
Authors: Xia Yang, Dating Sun, Hui Xiang, Sichen Wang, Yongping Huang, Ling Li, Xu Cheng, Hui Liu, Fengjiao Hu, Yanjie Cheng, Tengfei Ma, Manli Hu, Han Tian, Song Tian, Yan Zhou, Peng Zhang, Xiao‐Jing Zhang, Yan‐Xiao Ji, Yufeng Hu, Hongliang Li, Zhi‐Gang She
Journal: Hepatology (2021)

Background and Aims NAFLD has become the most common liver disease worldwide but lacks a well‐established pharmacological therapy. Here, we aimed to investigate the role of an E3 ligase SH3 domain‐containing ring finger 2 (SH3RF2) in NAFLD and to further explore the underlying mechanisms. Methods and Results In this study, we found that SH3RF2 was suppressed in the setting of NAFLD across mice, monkeys, and clinical individuals. Based on a genetic interruption model, we further demonstrated that hepatocyte SH3RF2 deficiency markedly deteriorates lipid accumulation in cultured hepatocytes and diet‐induced NAFLD mice. Mechanistically, SH3RF2 directly binds to ATP citrate lyase, the primary enzyme promoting cytosolic acetyl–coenzyme A production, and promotes its K48‐linked ubiquitination‐dependent degradation. Consistently, acetyl–coenzyme A was significantly accumulated in Sh3rf2 ‐knockout hepatocytes and livers compared with wild‐type controls, leading to enhanced de novo lipogenesis, cholesterol production, and resultant lipid deposition. Conclusion SH3RF2 depletion in hepatocytes is a critical aggravator for NAFLD progression and therefore represents a promising therapeutic target for related liver diseases.
Re: Hoffer et al.: Update on intraocular lens power calculation study protocols: the better way to design and report clinical trials (Ophthalmology. 2020 Jul 9 [Epub ahead of print])
Authors: Marko M Popovic, Austin Pereira, Matthew B Schlenker
Journal: Ophthalmology (2021)

We read the updated recommendations for designing and reporting studies on intraocular lens (IOL) power calculation formulas by Hoffer and Savini.1 We thank the authors and the IOL Power Club for their valuable contributions to this field.
Emergency Intubation in Covid-19
Authors: Nicolas Herzog, Christophe Giacardi, Marc Danguy des Déserts
Journal: New England Journal of Medicine (2021)

To the Editor: The video by Shrestha et al. (Feb.18 issue) 1 shows a method for emergency intubation in a patient with Covid-19 that includes the use of a negative-pressure isolation room.This measure was initially recommended to prevent hospital-acquired infections.However, negative air pressure in rooms in the intensive care unit could increase the risk of invasive pulmonary aspergillosis, 2 which has been reported in 10 to 30% of patients with Covid-19 in the intensive care unit. 3 Positive-pressure isolation rooms are used to reduce the risk of invasive pulmonary aspergillosis in immunocompromised patients, but their use is not suitable for patients with Covid-19 owing to the risk of airborne transmission.Air quality can be controlled through other solutions, such as portable high-efficiency particulate air (HEPA) filters. 4 These filters have proven efficiency in the capture of SARS-CoV-2 particles, and some results have suggested that their use leads to a reduction in the incidence of invasive pulmonary aspergillosis among high-risk patients. 5 We suggest that patients with Covid-19 undergo intubation in a neutral-pressure, rather than negative-pressure, room with a portable HEPA filtration system to reduce the incidence of invasive pulmonary aspergillosis.
Interventions and outcomes of adult patients with B-ALL progressing after CD19 chimeric antigen receptor T-cell therapy
Authors: Kitsada Wudhikarn, Jessica R. Flynn, Isabelle Rivière, Mithat Gönen, Xiuyan Wang, Brigitte Senechal, Kevin J. Curran, Mikhail Roshal, Peter G. Maslak, Mark B. Geyer, Elizabeth F. Halton, Claudia Diamonte, Marco L. Davila, Michel Sadelain, Renier J. Brentjens, Jae H. Park
Journal: Blood (2021)
Race, Policing, and History — Remembering the Freedom House Ambulance Service
Authors: Matthew L. Edwards
Journal: New England Journal of Medicine (2021)

to set standards for RPM devices to qualify for coverage.Furthermore, private-sector efforts to create transparency regarding the usability, validation, and data-security profiles of biosensors will support clinicians and researchers in technology-adoption decisions.The CMS rule changes and the pandemic have resulted in rapid and sweeping expansion of reimbursement for telehealth and RPM technologies and services without evidence-based coverage decisions.Given social-distancing recommendations and the desire to enhance patient safety, RPM provides promising solutions for accessible, data-driven care while reducing exposure risks.As RPM tools evolve, we may have opportunities to learn from other countries; for example, Germany's 2019 Digital Healthcare Act, which provides for insurance coverage of certain digital health applications, includes provisions for evidence generation as a requirement for ongoing reimbursement.Rig-orous, ongoing evaluation of RPM devices and platforms will be essential for elucidating their value and driving coverage decisions and adoption programs for the most effective solutions.
Abstract 14823: Prevalence and Natural History of Incidentally Diagnosed Pulmonary Embolism in Patients Undergoing Coronary Computed Tomography Angiography
Authors: Tomohiko Taniguchi, Masashi Kato, Takafumi Yokomatsu, Shuzo Ueda, Akihiro Kushiyama, Hidenori Yaku, Yutaka Kohno, Tetsu Mizoguchi, Shinji Miki, Akira Yoshida
Journal: Circulation (2012)

Introduction: Although clinically unsuspected pulmonary embolism (PE) can be detected in patients undergoing coronary computed tomography angiography (CTA), the natural history of these incidentall...
Dynamic microangiography of the gastrointestinal mucosa using magnifying Blue Light Imaging
Authors: Shunsuke Yamamoto, Helmut Neumann
Journal: Endoscopy (2021)

With the emergence of image-enhanced endoscopy (IEE), it is no longer difficult to visualize the microvasculature in the gastrointestinal (GI) tract [1] [2]. Magnifying Blue Light Imaging (BLI; Fujifilm, Tokyo, Japan) provides enhanced images of superficial vessels in the GI tract as hemoglobin absorbs light with a narrow wavelength. A substantial number of studies using Blue Light Imaging have been conducted, but none of them have focused on its advantage in visualizing the dynamic microvascular architecture with the microcirculation of red blood cells.
International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in Western Europe
Authors: Dearbhla M. Kelly, Hans-Joachim Anders, Aminu K. Bello, Gabriel Choukroun, Rosanna Coppo, Gavin Dreyer, Kai-Uwe Eckardt, David W. Johnson, Vivekanand Jha, David C.H. Harris, Adeera Levin, Meaghan Lunney, Valerie Luyckx, Hans-Peter Marti, Piergiorgio Messa, Thomas F. Mueller, Syed Saad, Benedicte Stengel, Raymond C. Vanholder, Talia Weinstein, Maryam Khan, Deenaz Zaidi, Mohamed A. Osman, Feng Ye, Marcello Tonelli, Ikechi G. Okpechi, Eric Rondeau
Journal: Kidney International Supplements (2021)
Allergens and their associated small molecule ligands—their dual role in sensitization
Authors: Maksymilian Chruszcz, Fook Tim Chew, Karin Hoffmann‐Sommergruber, Barry K. Hurlburt, Geoffrey A. Mueller, Anna Pomés, Juha Rouvinen, Mayte Villalba, Birgitta M. Wöhrl, Heimo Breiteneder
Journal: Allergy (2021)

Abstract Many allergens feature hydrophobic cavities that allow the binding of primarily hydrophobic small‐molecule ligands. Ligand‐binding specificities can be strict or promiscuous. Serum albumins from mammals and birds can assume multiple conformations that facilitate the binding of a broad spectrum of compounds. Pollen and plant food allergens of the family 10 of pathogenesis‐related proteins bind a variety of small molecules such as glycosylated flavonoid derivatives, flavonoids, cytokinins, and steroids in vitro. However, their natural ligand binding was reported to be highly specific. Insect and mammalian lipocalins transport odorants, pheromones, catecholamines, and fatty acids with a similar level of specificity, while the food allergen β‐lactoglobulin from cow's milk is notably more promiscuous. Non‐specific lipid transfer proteins from pollen and plant foods bind a wide variety of lipids, from phospholipids to fatty acids, as well as sterols and prostaglandin B2, aided by the high plasticity and flexibility displayed by their lipid‐binding cavities. Ligands increase the stability of allergens to thermal and/or proteolytic degradation. They can also act as immunomodulatory agents that favor a Th2 polarization. In summary, ligand‐binding allergens expose the immune system to a variety of biologically active compounds whose impact on the sensitization process has not been well studied thus far.
The detection and prediction of circulating tumor cells in breast cancer patients
Authors: Tim Molloy, Helgi Helgason, Astrid Bosma, Laura van't Veer
Journal: Cancer Research (2008)

3696A  Abstract 3696A has been selected for inclusion in the AACR’s Annual Meeting press program and is therefore embargoed until date and time of press briefing or scientific presentation, whichever comes first. The abstract is scheduled for scientific presentation and will be posted to this site at or after the following date and time: 4/15/2008 8:00 AM.
Esophageal lumen recreated with a self-expanding metal stent in a deep submucosal tunnel: a successful way to treat a refractory stricture
Authors: Caroline Dellestable, Thomas Lambin, Jérôme Rivory, Jean-Christophe Saurin, Jérémie Jacques, Thierry Ponchon, Mathieu Pioche
Journal: Endoscopy (2021)

Esophageal strictures can be refractory to endoscopic dilations, making the goal of achieving oral feeding challenging. Self-expandable metal stents (SEMS) have been disappointing, with low success rates [1] [2] [3]. For complete esophageal obstruction, recanalization by endoscopic submucosal dissection (ESD) has been described, bridging between the upper and the lower edges of the stricture beneath the mucosa [4]. Previous experience of ESD for recurrent lesions has taught us that a residual nonfibrotic submucosal layer can be present close to the muscle [5].
A novel technique for endoscopic removal of foreign bodies using a balloon and transparent cap
Authors: Wenyue Wu, Yi Han, Derun Kong
Journal: Endoscopy (2021)

The presence of foreign bodies in the esophagus is a common clinical emergency and induces discomfort in patients, including chest pain or dysphagia, but may also result in more severe complications, such as hemorrhage and esophageal perforation [1]. We report a novel method of removing large foreign bodies using a balloon with the assistance of a transparent cap.
A Call to Action for New Global Approaches to Cardiovascular Disease Drug Solutions
Authors: Gemma A. Figtree, Keith Broadfoot, Barbara Casadei, Robert Califf, Filippo Crea, Grant R. Drummond, Jane E. Freedman, Tomasz J. Guzik, David Harrison, Derek J. Hausenloy, Joseph A. Hill, James L. Januzzi, Bronwyn A. Kingwell, Carolyn S.P. Lam, Calum A. MacRae, Frank Misselwitz, Tetsuji Miura, Rebecca H. Ritchie, Maciej Tomaszewski, Joseph C. Wu, Junjie Xiao, Faiez Zannad
Journal: Circulation (2021)

While we continue to wrestle with the immense challenge of implementing equitable access to established evidence-based treatments, substantial gaps remain in our pharmacotherapy armament for common forms of cardiovascular disease including coronary and peripheral arterial disease, heart failure, hypertension, and arrhythmia. We need to continue to invest in the development of new approaches for the discovery, rigorous assessment, and implementation of new therapies. Currently, the time and cost to progress from lead compound/product identification to the clinic, and the success rate in getting there reduces the incentive for industry to invest, despite the enormous burden of disease and potential size of market. There are tremendous opportunities with improved phenotyping of patients currently batched together in syndromic "buckets." Use of advanced imaging and molecular markers may allow stratification of patients in a manner more aligned to biological mechanisms that can, in turn, be targeted by specific approaches developed using high-throughput molecular technologies. Unbiased "omic" approaches enhance the possibility of discovering completely new mechanisms in such groups. Furthermore, advances in drug discovery platforms, and models to study efficacy and toxicity more relevant to the human disease, are valuable. Re-imagining the relationships among discovery, translation, evaluation, and implementation will help reverse the trend away from investment in the cardiovascular space, establishing innovative platforms and approaches across the full spectrum of therapeutic development.
THU0081 MIR-17-5P REDUCES INFLAMMATION AND BONE EROSIONS IN COLLAGEN INDUCED ARTHRITIS MICE AND DIRECTLY TARGETS THE JAK-STAT PATHWAY IN RHEUMATOID ARTHRITIS FIBROBLAST-LIKE SYNOVIOCYTES.
Authors: A. Najm, F. M. Masson, P. Preuss, S. Georges, B. Ory, T. Quillard, D. Veale, U. Fearon, B. Le Goff, F. Blanchard
Journal: Annals of the Rheumatic Diseases (2020)

Background: micro-RNAs (miR) are strong regulators of gene expression. Their involvement in RA key cytokines pathway regulation entitles them as important players in RA pathophysiology. The miR 17-92 cluster has been widely studied in cancer as they regulate cell apoptosis. Objectives: The aims of this study were to screen miR 17-92 cluster’s expression in different RA phenotypes (erosive and non erosive), further elucidate the mechanisms and direct targets involved in miR-17-5p anti-inflammatory role and to investigate miR-17-5p therapeutic effect in arthritis. Methods: A miR array was performed in synovial tissue from naïve erosive and non-erosive RA patients. Intra-articular delivery of miR-17 lipoplex was performed in collagen induced arthritis model in mice. Clinical, histological and structural effects were studied over the course of arthritis. In depth studies of miR-17 mechanisms of action were performed in primary RA-FLS isolated from RA synovial tissue. Results: Among others, miR-17-5p expression was reduced in erosive RA. miR-17 transfection in arthritic paws significantly reduced clinical inflammation. Moreover, synovial B cells, T cells, macrophages and polynuclear neutrophils infiltrates were significantly reduced. Structural damage was also decreased as shown by a reduction in the number of osteoclasts and erosion score by CT analysis. Pro-inflammatory cytokines of the IL-6 family, STAT3 target genes and IL-1β expression were also significantly reduced, but not TNF-alpha. miR17 directly targeted the 3’-untranslated region of STAT3 and JAK1. STAT3 and JAK1 mRNA and protein expression were reduced in RA-FLS following miR-17 transfection. STAT3 and JAK1 mRNA and activation of STAT3 as assessed by immunohistochemistry were also reduced in injected paws. Conclusion: We demonstrate an anti-inflammatory and anti-erosive role of miR-17 in vivo. This effect involves the suppression of the IL-6 family autocrine amplifying loop through the direct targeting of JAK1 and STAT3 as shown in RA-FLS. Figure Effect of miR-17 lipoplex injection in Collagen induced arthritis (CIA) mice’s ankles. Disclosure of Interests: None declared
Vascularized Microfluidics and Their Untapped Potential for Discovery in Diseases of the Microvasculature
Authors: David R. Myers, Wilbur A. Lam
Journal: Annual Review of Biomedical Engineering (2021)

Microengineering advances have enabled the development of perfusable, endothelialized models of the microvasculature that recapitulate the unique biological and biophysical conditions of the microcirculation in vivo. Indeed, at that size scale (<100 μm)-where blood no longer behaves as a simple continuum fluid; blood cells approximate the size of the vessels themselves; and complex interactions among blood cells, plasma molecules, and the endothelium constantly ensue-vascularized microfluidics are ideal tools to investigate these microvascular phenomena. Moreover, perfusable, endothelialized microfluidics offer unique opportunities for investigating microvascular diseases by enabling systematic dissection of both the blood and vascular components of the pathophysiology at hand. We review (a) the state of the art in microvascular devices and (b) the myriad of microvascular diseases and pressing challenges. The engineering community has unique opportunities to innovate with new microvascular devices and to partner with biomedical researchers to usher in a new era of understanding and discovery of microvascular diseases.
Drop in biological initiation for patients with psoriasis during the COVID‐19 pandemic
Authors: L. Penso, R. Dray‐Spira, A. Weill, M. Zureik, E. Sbidian
Journal: British Journal of Dermatology (2021)

Biologics have become the backbone of chronic inflammatory diseases treatment, including psoriasis. Post-approval studies allowed to better understand their safety profile demonstrating a favorable risk-benefit ratio despite an increased risk of infection, and especially an increased risk of bacterial infection with anti-TNF agents.
Rapid corticosteroid taper versus standard of care for immune checkpoint inhibitor induced nephritis: a single-center retrospective cohort study
Authors: Meghan D Lee, Harish Seethapathy, Ian A Strohbehn, Sophia H Zhao, Genevieve M Boland, Riley Fadden, Ryan Sullivan, Kerry L Reynolds, Meghan E Sise
Journal: Journal for ImmunoTherapy of Cancer (2021)

Current guidelines for treatment of immune checkpoint inhibitor (ICI)-induced nephritis are not evidence based and may lead to excess corticosteroid exposure. We aimed to compare a rapid corticosteroid taper to standard of care.
Impact of Pathogenic Germline DNA Damage Repair alterations on Response to Intense Neoadjuvant Androgen Deprivation Therapy in High-risk Localized Prostate Cancer
Authors: Jacob E Berchuck, Zhenwei Zhang, Rebecca Silver, Lucia Kwak, Wanling Xie, Gwo-Shu Mary Lee, Matthew L Freedman, Adam S Kibel, Eliezer M Van Allen, Rana R McKay, Mary-Ellen Taplin
Journal: European Urology (2021)
PROGNOSTIC VALUE OF ELEVATED HIGH-SENSITIVITY TROPONIN LEVEL IN COVID-19 ASSOCIATED HOSPITALIZATIONS IN THE SOUTH BRONX
Authors: Bing Yue, Preeti Jadhav, Niel Shah, Miguel Rodriguez Guerra, Haiming Tang, Haozhe Sun, Shoaib Ashraf, Nikee Shrestha, Sameer Kandhi, Harika Kalangi, Siddharth Chinta, Sunita Karki, Chayakrit Krittanawong, Timothy J. Vittorio, Jonathan N. Bella, Amandeep Singh
Journal: Journal of the American College of Cardiology (2021)
The Geometry of Information Coding in Correlated Neural Populations
Authors: Rava Azeredo da Silveira, Fred Rieke
Journal: Annual Review of Neuroscience (2021)

Neurons in the brain represent information in their collective activity. The fidelity of this neural population code depends on whether and how variability in the response of one neuron is shared with other neurons. Two decades of studies have investigated the influence of these noise correlations on the properties of neural coding. We provide an overview of the theoretical developments on the topic. Using simple, qualitative and general arguments, we discuss, categorize, and relate the various published results. We emphasize the relevance of the fine structure of noise correlation, and we present a new approach to the issue. Throughout we emphasize a geometrical picture of how noise correlations impact the neural code.
Chronic suppurative skin lesions in a young woman
Authors: Paul Arkell, Tanizio E Florindo, Rob Baird, Christopher Babua
Journal: BMJ (2021)

A woman in her early 20s presented with skin ulcers and swellings on her neck, right axilla, and chest, which had gradually worsened over six months. Her presentation was delayed because she was anxious about receiving medical care, and travel to the clinic was difficult and costly.

The lesions began as painful swellings, which later ulcerated and produced a cream coloured discharge. The patient had no fever or respiratory symptoms. Ten years earlier she had received eight weeks of empirical antituberculosis treatment for similar skin eruptions. This had resulted in some improvement, but she had stopped treatment early because her family thought that a longer course was not necessary.

On examination she weighed 35 kg, with a body mass index of 16.6 kg/m2, and muscle wasting was evident. She had no pallor or jaundice, and vital signs were within normal limits. The patient had bilateral …
A clinical and biological review of keratoacanthoma*
Authors: A. Tisack, A. Fotouhi, C. Fidai, B.J. Friedman, D. Ozog, J. Veenstra
Journal: British Journal of Dermatology (2021)

Keratoacanthoma (KA) is a common skin tumour that remains controversial regarding classification, epidemiology, diagnosis, prognosis and management. Classically, a KA manifests as a rapidly growing, well-differentiated, squamoid lesion with a predilection for sun-exposed sites in elderly people and a tendency to spontaneously regress. Historically, KAs have been considered a variant of cutaneous squamous cell carcinoma (cSCC) and are often reported as KA-type cSCC. However, the penchant for regression has led many to categorize KAs as biologically benign tumours with distinct pathophysiological mechanisms from malignant cSCC. The clinical and histopathological similarities between KA and cSCC, particularly the well-differentiated variant of cSCC, have made definitive differentiation difficult or impossible in many cases. The ambiguity between entities has led to the general recommendation for surgical excision of KAs to ensure a potentially malignant cSCC is not left untreated. This current standard creates unnecessary surgical morbidity and financial strain for patients, especially the at-risk elderly population. There have been no reports of death from a definitive KA to date, while cSCC has an approximate mortality rate of 1·5%. Reliably distinguishing cSCC from KA would shift management strategies for KAs towards less-invasive treatment modalities, prevent unnecessary surgical morbidity, and likely reduce associated healthcare costs. Herein, we review the pathophysiology and clinical characteristics of KA, and conclude on the balance of current evidence that KA is a benign lesion and distinct from cSCC.
日本におけるKeysスコア,食事脂質,血清総コレステロール間の関係における時間関連変化-NIPPON DATA80/90/2010-
Authors: Okami Yukiko, Ueshima Hirotsugu, Nakamura Yasuyuki, Kondo Keiko, Kadota Aya, Okuda Nagako, Okamura Tomonori, Miura Katsuyuki
Journal: Circulation (2018)
HYPERDYNAMIC LEFT VENTRICULAR EJECTION FRACTION IS A POOR PROGNOSTIC SIGN IN COVID-19 INFECTION
Authors: Max Ruge, Joanne Michelle D. Gomez, Jeanne Du Fay de Lavallaz, J. Alan Simmons, Jessica Canzolino, Annabelle Santos Volgman, Kim Williams, Anupama Rao, Karolina Marinescu, Tisha Suboc
Journal: Journal of the American College of Cardiology (2021)