tbuckley/cabot-search huggingface dataset:
Estimation of Breast Cancer Overdiagnosis in a U.S. Breast Screening Cohort
Authors: Marc D. Ryser, Jane Lange, Lurdes Y.T. Inoue, Ellen S. O’Meara, Charlotte Gard, Diana L. Miglioretti, Jean-Luc Bulliard, Andrew F. Brouwer, E. Shelley Hwang, Ruth B. Etzioni
Journal: Annals of Internal Medicine (2022)

Background: Mammography screening can lead to overdiagnosis—that is, screen-detected breast cancer that would not have caused symptoms or signs in the remaining lifetime. There is no consensus about the frequency of breast cancer overdiagnosis. Objective: To estimate the rate of breast cancer overdiagnosis in contemporary mammography practice accounting for the detection of nonprogressive cancer. Design: Bayesian inference of the natural history of breast cancer using individual screening and diagnosis records, allowing for nonprogressive preclinical cancer. Combination of fitted natural history model with life-table data to predict the rate of overdiagnosis among screen-detected cancer under biennial screening. Setting: Breast Cancer Surveillance Consortium (BCSC) facilities. Participants: Women aged 50 to 74 years at first mammography screen between 2000 and 2018. Measurements: Screening mammograms and screen-detected or interval breast cancer. Results: The cohort included 35 986 women, 82 677 mammograms, and 718 breast cancer diagnoses. Among all preclinical cancer cases, 4.5% (95% uncertainty interval [UI], 0.1% to 14.8%) were estimated to be nonprogressive. In a program of biennial screening from age 50 to 74 years, 15.4% (UI, 9.4% to 26.5%) of screen-detected cancer cases were estimated to be overdiagnosed, with 6.1% (UI, 0.2% to 20.1%) due to detecting indolent preclinical cancer and 9.3% (UI, 5.5% to 13.5%) due to detecting progressive preclinical cancer in women who would have died of an unrelated cause before clinical diagnosis. Limitations: Exclusion of women with first mammography screen outside BCSC. Conclusion: On the basis of an authoritative U.S. population data set, the analysis projected that among biennially screened women aged 50 to 74 years, about 1 in 7 cases of screen-detected cancer is overdiagnosed. This information clarifies the risk for breast cancer overdiagnosis in contemporary screening practice and should facilitate shared and informed decision making about mammography screening. Primary Funding Source: National Cancer Institute.
A COMPUTER-ASSISTED AUTOMATED APPORACH FOR OPTICAL CLASSIFICATION OF COLORECTAL POLYPS INCLUDING SERRATED ADENOMAS – THE CASSANDRA STUDY
Authors: P. Klare, R.D Soberanis-Mukul, B. Haller, B. Walter, T. Rath, S. Albarquoni, N. Navab, A. Poszler, R.M. Schmid, A.-M. Zvereva
Journal: Endoscopy (2022)

Aims Computer-assisted models (CAM) aim to differntiate neoplastic and non-neoplastic polyps based on their optical features. However, differentiation of serrated adenomas (SA) from hyperplastic polyps (HP) and adenomas (AD) is still challenging. We aspired to develop a CAM for automated polyp classification between said polyp classes.
Genetic Subtyping and Phenotypic Characterization of the Immune Microenvironment and MYC/BCL2 Double Expression Reveal Heterogeneity in Diffuse Large B-cell Lymphoma
Authors: Zijun Y. Xu-Monette, Li Wei, Xiaosheng Fang, Qingyan Au, Harry Nunns, Máté Nagy, Alexandar Tzankov, Feng Zhu, Carlo Visco, Govind Bhagat, Karen Dybkaer, April Chiu, Wayne Tam, Youli Zu, Eric D. Hsi, Fredrick B. Hagemeister, Xiaoping Sun, Xin Han, Heounjeong Go, Maurilio Ponzoni, Andrés J.M. Ferreri, Michael B. Møller, Benjamin M. Parsons, J. Han van Krieken, Miguel A. Piris, Jane N. Winter, Yong Li, Bing Xu, Maher Albitar, Hua You, Ken H. Young
Journal: Clinical Cancer Research (2022)

Abstract Purpose: Diffuse large B-cell lymphoma (DLBCL) is molecularly and clinically heterogeneous, and can be subtyped according to genetic alterations, cell-of-origin, or microenvironmental signatures using high-throughput genomic data at the DNA or RNA level. Although high-throughput proteomic profiling has not been available for DLBCL subtyping, MYC/BCL2 protein double expression (DE) is an established prognostic biomarker in DLBCL. The purpose of this study is to reveal the relative prognostic roles of DLBCL genetic, phenotypic, and microenvironmental biomarkers. Experimental Design: We performed targeted next-generation sequencing; IHC for MYC, BCL2, and FN1; and fluorescent multiplex IHC for microenvironmental markers in a large cohort of DLBCL. We performed correlative and prognostic analyses within and across DLBCL genetic subtypes and MYC/BCL2 double expressors. Results: We found that MYC/BCL2 double-high-expression (DhE) had significant adverse prognostic impact within the EZB genetic subtype and LymphGen-unclassified DLBCL cases but not within MCD and ST2 genetic subtypes. Conversely, KMT2D mutations significantly stratified DhE but not non-DhE DLBCL. T-cell infiltration showed favorable prognostic effects within BN2, MCD, and DhE but unfavorable effects within ST2 and LymphGen-unclassified cases. FN1 and PD-1–high expression had significant adverse prognostic effects within multiple DLBCL genetic/phenotypic subgroups. The prognostic effects of DhE and immune biomarkers within DLBCL genetic subtypes were independent although DhE and high Ki-67 were significantly associated with lower T-cell infiltration in LymphGen-unclassified cases. Conclusions: Together, these results demonstrated independent and additive prognostic effects of phenotypic MYC/BCL2 and microenvironment biomarkers and genetic subtyping in DLBCL prognostication, important for improving DLBCL classification and identifying prognostic determinants and therapeutic targets.
ASYMMETRICALLY DOSED 1L PEG+ASC DEMONSTRATES HIGH-QUALITY CLEANSING EFFICACY COMPARED WITH COMPARATOR SOLUTIONS ACROSS CLINICAL TRIALS
Authors: D. Poppers, C. Allen, P. Sharma, C. Hassan
Journal: Endoscopy (2022)

Aims High-quality (HQ) cleansing may be associated with more favourable colonoscopy outcomes, such as improvement in adenoma detection rate, than adequate level cleansing. In randomised trials, 1L polyethylene glycol and ascorbate (asymmetrically dosed PEG+ASC, or ner1006) showed additional efficacy in achieving HQ cleansing compared with 2L PEG+ASC, trisulphate or sodium picosulphate (1,2). The aim of this study was to indirectly compare the HQ cleansing efficacy of 1L PEG+ASC with comparators including 4L, 2L and lower volume preparations.
A VIRTUAL CHROMOENDOSCOPY ARTIFICIAL INTELLIGENCE SYSTEM TO DETECT ENDOSCOPIC AND HISTOLOGIC REMISSION IN ULCERATIVE COLITIS
Authors: M. Iacucci, R. Cannatelli, T.L. Parigi, A. Buda, N. Labarile, O.M. Nardone, G.E. Tontini, A. Rimondi, A. Bazarova, P. Bhandari, R. Bisschops, G. De Hertogh, R. del Amor, J.G Ferraz, M. Goetz, X. Gui, B. Hayee, R. Kiesslich, M. Lazarev, V. Naranjo, R. Panaccione, A. Parra-Blanco, L. Pastorelli, T. Rath, E.S Røyset, M. Vieth, V. Villanacci, D. Zardo, S. Ghosh, E. Grisan
Journal: Endoscopy (2022)

Aims We aimed to develop an artificial intelligence (AI) system to assess endoscopic remission (ER) and histologic remission (HR) of ulcerative colitis (UC) in both white light (WL, using Ulcerative Colitis Endoscopic Index of Severity [UCEIS]) and virtual chromoendoscopy (VCE, using Paddington International Virtual ChromoendoScopy ScOre [PICaSSO]).
59MO Adjuvant abemaciclib combined with endocrine therapy (ET): Efficacy results in monarchE cohort 1
Authors: M. Toi, F. Boyle, Y.-H. Im, M. Reinisch, D. Molthrop, Z. Jiang, R.J. Wei, F. Sapunar, B. Grimes, S.C. Nabinger, S.R.D. Johnston
Journal: Annals of Oncology (2022)
EFFECTIVENESS AND TOLERABILITY OF COLONOSCOPY PREPARATION WITH 1L PEG+ASCORBIC ACID VERSUS SODIUM PICOSULPHATE WITH MAGNESIUM CITRATE IN ELDERLY PATIENTS IN A REAL LIFE SETTING
Authors: E. Perez Arellano, M.I. Rodríguez García, A.B. Galera Ródano, A. Flores, E. de la Morena Madrigal
Journal: Endoscopy (2022)

Aims Inadequate intestinal cleansing is significantly more common in elderly patients, so colonoscopy is considered more challenging than usual due to the difficulty of preparation in this population. This study aims to compares the effectiveness and tolerability of a low volume 1L polyethylene glycol (PEG)+ascorbic acid (1L PEG+A) versus Sodium Picosulphate with Magnesium Citrate (SPMC) in patients≥65 years old.
IMPLEMENTATION OF BOTH BSG 2019 AND ESGE 2020 POLYPECTOMY SURVEILLANCE GUIDELINES SAFELY REDUCES THE BURDEN OF SURVEILLANCE IN A SCREENING COHORT – A VIRTUAL MODEL STUDY
Authors: R. Stack, J. Doherty, N. O'Morain, B. Nolan, G. Horgan, J. Sheridan, M. Buckley, E. Mc Dermott, H. Mulcahy, G. Cullen, G. Doherty
Journal: Endoscopy (2022)

Aims To evaluate the impact of BSG 2019 and ESGE 2020 polypectomy surveillance guidelines within a national FIT-based bowel cancer screening (BS) cohort on surveillance activity and detection of pathology by retrospective virtual application.
EUS-GUIDED HEPATOGASTROSTOMY FOR AFFERENT LOOP SYNDROME
Authors: M. Borahma, I. Benelbarhdadi, F.Z. Ajana
Journal: Endoscopy (2022)

A 61 old-year-male, with a medical history of Whipple surgery for pancreatic head adenocarcinoma nine months ago, was admitted for acute cholangitis. The clinical examination noted cholestatic jaundice and scratching lesions. CT scan showed a malignant relapse on the afferent loop with dilation of this afferent loop and upstream dilation of the common bile duct and intrahepatic duct. we performed an endoscopic ultrasound-guided hepatogastrostomy for this afferent loop syndrome
CHRONIC DIARRHEA OVER THE AGE OF 65: THE VALUE OF COLONOSCOPY
Authors: A. Benhamdane, A. Sair, A. Touibi, T. Addajou, S. Rokhsi, S. Mrabti, R. Berraida, I. El Koti, F. Rouibaa, A. Benkirane, H. Seddik
Journal: Endoscopy (2022)

Aims Our objective is to determine the pertinence of colonoscopy in the exploration of chronic diarrhea in the elderly and the particularity compared to younger subjects.
Gestational Perfluoroalkyl Substance Exposure and DNA Methylation at Birth and 12 Years of Age: A Longitudinal Epigenome-Wide Association Study
Authors: Yun Liu, Melissa N. Eliot, George D. Papandonatos, Karl T. Kelsey, Ruby Fore, Scott Langevin, Jessie Buckley, Aimin Chen, Bruce P. Lanphear, Kim M. Cecil, Kimberly Yolton, Marie-France Hivert, Sharon K. Sagiv, Andrea A. Baccarelli, Emily Oken, Joseph M. Braun
Journal: Environmental Health Perspectives (2022)

Background: DNA methylation alterations may underlie associations between gestational perfluoroalkyl substances (PFAS) exposure and later-life health outcomes. To the best of our knowledge, no longitudinal studies have examined the associations between gestational PFAS and DNA methylation. Objectives: We examined associations of gestational PFAS exposure with longitudinal DNA methylation measures at birth and in adolescence using the Health Outcomes and Measures of the Environment (HOME) Study (2003–2006; Cincinnati, Ohio). Methods: We quantified serum concentrations of perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoate (PFNA), and perfluorohexane sulfonate (PFHxS) in mothers during pregnancy. We measured DNA methylation in cord blood (n=266) and peripheral leukocytes at 12 years of age (n=160) using the Illumina HumanMethylation EPIC BeadChip. We analyzed associations between log2-transformed PFAS concentrations and repeated DNA methylation measures using linear regression with generalized estimating equations. We included interaction terms between children's age and gestational PFAS. We performed Gene Ontology enrichment analysis to identify molecular pathways. We used Project Viva (1999–2002; Boston, Massachusetts) to replicate significant associations. Results: After adjusting for covariates, 435 cytosine–guanine dinucleotide (CpG) sites were associated with PFAS (false discovery rate, q<0.05). Specifically, we identified 2 CpGs for PFOS, 12 for PFOA, 8 for PFHxS, and 413 for PFNA; none overlapped. Among these, 2 CpGs for PFOA and 4 for PFNA were replicated in Project Viva. Some of the PFAS-associated CpG sites annotated to gene regions related to cancers, cognitive health, cardiovascular disease, and kidney function. We found little evidence that the associations between PFAS and DNA methylation differed by children's age. Discussion: In these longitudinal data, PFAS biomarkers were associated with differences in several CpGs at birth and at 12 years of age in or near genes linked to some PFAS-associated health outcomes. Future studies should examine whether DNA methylation mediates associations between gestational PFAS exposure and health. https://doi.org/10.1289/EHP10118
SELF-EXPANDABLE METAL STENTS IN ESOPHAGEAL CANCER BEFORE PREOPERATIVE NEOADJUVANT THERAPY: EFFICACY, SAFETY AND LONG-TERM OUTCOMES
Authors: J. Ferreira-Silva, E. Rodrigues-Pinto, P. Pereira, G. Macedo
Journal: Endoscopy (2022)

Aims Evaluate self-expandable metal stent (SEMS) placement impact on clinical and oncologic outcomes in patients with esophageal cancer who underwent surgery after neoadjuvant therapy (NT).
PERFORMANCE OF ABDOMINAL ULTRASOUND AND ALBUMIN, BILIRUBIN, AND PLATELETS CRITERIA IN PREDICTING THE ABSENCE OF HIGH-RISK ESOPHAGEAL VARICES
Authors: N. Trad, G. Mohamed, S. Bizid, I. Gamgami, B. Ben Slimane, K. Boughoula, H. Ben Abdallah, R. Bouali, M.N. Abdelli
Journal: Endoscopy (2022)

Aims Esophageal varices are a serious complication of portal hypertension(PHT). Their diagnosis is based on upper digestive endoscopy(UGIE) which is an invasive examination. We aimed to evaluate the performance of abdominal ultrasound(AU) and ABP in the prediction of the absence of high-risk esophageal varices(HRV).
EFFICACY OF AGGRESSIVE PERIPROCEDURAL HYDRATION IN THE PREVENTION OF POST-ERCP PANCREATITIS: AN OBSERVATIONAL STUDY
Authors: G. Tripodi, S. Giannitti, G. D'ambra, B. Annibale, S. Angeletti
Journal: Endoscopy (2022)

Aims Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is the most common complication of ERCP. Aggressive periprocedural hydration (APH) in addition to rectal administration of NSAIDs has been proposed to further reduce incidence of PEP with discordant results. We aimed to evaluate the added value of APH in reducing incidence of PEP in patients undergoing ERCP.
ENDOSCOPIC ULTRASOUND-GUIDED GASTROENTERIC ANASTOMOSIS: A SINGLE CENTER SERIES EMPHASIZING BENIGN INDICATIONS
Authors: J.-M. Gonzalez, S. Ouazzani, M. Gasmi, M. Barthet
Journal: Endoscopy (2022)

Aims Endoscopic ultrasound-guided gastroenteric anastomosis (EUS-GEA) is a minimally invasive alternative to surgery for treating gastric outlet obstruction (GOO). This series is a single center cohort performing EUS-GE with the same manner, highlighting the rate of benign indications and management of stent dislodgement.
FEASIBILITY OF IMPLEMENTING THE USE OF REGULAR ARRANGEMENT OF COLLECTING VENULES IN DAILY ENDOSCOPY PRACTICE WITHOUT PRIOR TRAINING: RESULTS FROM A PROSPECTIVE OBSERVATIONAL STUDY
Authors: G. Rasschaert, L. Vandermeulen, M. Schils
Journal: Endoscopy (2022)

Aims Identification of regular arrangement of collecting venules (RAC) has been proposed an accurate tool for detection of Helicobacter pylori (Hp) negative patients. Its use is not implemented widespread in daily endoscopy practice. Although suggested easy to apply, a potential barrier is the supposed necessity of training for this type of optical diagnosis. Can the concept of RAC be implemented in daily practice without prior training?
POEM, SEPTOTOMY AND RESTORATION OF ESOPHAGEAL LUMEN WITH OTSC. CLOSING THE CIRCLE OF ESOPHAGEAL DIVERTICULA MANAGEMENT
Authors: E. Albéniz, F. Estremera-Arévalo, M. Gómez Alonso, P.J. Rosón, F.J. Gallego Rojo, J. Vila, S. Montori
Journal: Endoscopy (2022)

A patient with type III achalasia with three diverticula was treated by POEM. An uninterrupted posterior myotomy was performed to ensure complete dissection of the spastic segment. The myotomy was also driven to dissect the diverticula septum. The two bigger diverticula pouches were everted with over-scope clips (OTSC). Early barium swallow demonstrated restored esophageal anatomy with normal contrast flow. The patient remains asymptomatic on a full texture diet. A multimodal one-session endoscopic procedure treating both the underlying motility disorder and the diverticula, with restoration of the lumen mechanically (OTSC), will lead to better rates of therapeutic success.
10P Survival according to early ctDNA dynamics in advanced breast cancer (ABC) treated with endocrine therapy (ET) and a CDK4/6 inhibitor (CDK4/6i)
Authors: O. Martinez Saez, E. Felip Falgas, M. Cappelletti, P. Tolosa, F. Brasó-Maristany, E. Sanfeliu Torres, T. Pascual, N. Chic, M. Vidal, B. Adamo, M. Munoz, I. Faull, J. Odegaard, G. Patel, R. McEwen, D. Carroll, E.M. Ciruelos, D.G. Generali, M. Margeli Vila, A. Prat
Journal: Annals of Oncology (2022)
COMPARISON OF PREOPERATIVE AND POSTOPERATIVE FUNCTIONAL LUMINAL IMAGING PROBE MEASUREMENTS IN PATIENTS UNDERGOING PERORAL ENDOSCOPIC MYOTOMY FOR ACHALASIA
Authors: K. Gröhl, A. Ebigbo, E. Schnoy, H. Messmann, S. Nagl
Journal: Endoscopy (2022)

Aims The functional luminal imaging probe (FLIP) is a catheter-based device that measures esophagogastric junction (EGJ) distensibility. Previous studies have demonstrated that impedance planimetry measurements can predict clinical response following peroral endoscopic myotomy (POEM). This study aims to assess changes in distensibility index (DI), intraballoon pressure (IBP), cross-sectional Area (CSA) and minimum diameter (Dmin) in patients with untreated achalasia before, during and after POEM and to determine the most predictive measures for clinical response.
NIVOLUMAB-INDUCED ACUTE NEUTROPHILIC GASTRITIS: CASE REPORT IN A TERTIARY HOSPITAL
Authors: A. Ojeda Gómez, N. Jimenez García, A.M. Íñigo Chaves, A. Brotons Brotons, M.I. Pamies Ramon, P. Rodríguez Paya, J. Barragán Martinez, A. García Soria, J. Saez Fuster, M.F. García Sepulcre, J. Sola-Vera Sánchez
Journal: Endoscopy (2022)

Aims Immune-check-point blockade agents are extendedly used in the oncology field. Lower tract gastrointestinal toxicity is more frequent for anti-CTLA-4 than for anti-PD-L1, the target of Nivolumab. The immune-mediated gastritis or the esophagitis remain sporadic adverse events. However, two cases of acute pangastritis have been reported in six months in our center.
Oral and long‐acting antipsychotics for relapse prevention in schizophrenia‐spectrum disorders: a network meta‐analysis of 92 randomized trials including 22,645 participants
Authors: Giovanni Ostuzzi, Federico Bertolini, Federico Tedeschi, Giovanni Vita, Paolo Brambilla, Lorenzo del Fabro, Chiara Gastaldon, Davide Papola, Marianna Purgato, Guido Nosari, Cinzia Del Giovane, Christoph U. Correll, Corrado Barbui
Journal: World Psychiatry (2022)

According to current evidence and guidelines, continued antipsychotic treatment is key for preventing relapse in people with schizophrenia‐spectrum disorders, but evidence‐based recommendations for the choice of the individual antipsychotic for maintenance treatment are lacking. Although oral antipsychotics are often prescribed first line for practical reasons, long‐acting injectable antipsychotics (LAIs) are a valuable resource to tackle adherence issues since the earliest phase of disease. Medline, EMBASE, PsycINFO, CENTRAL and CINAHL databases and online registers were searched to identify randomized controlled trials comparing LAIs or oral antipsychotics head‐to‐head or against placebo, published until June 2021. Relative risks and standardized mean differences were pooled using random‐effects pairwise and network meta‐analysis. The primary outcomes were relapse and dropout due to adverse events. We used the Cochrane Risk of Bias tool to assess study quality, and the CINeMA approach to assess the confidence of pooled estimates. Of 100 eligible trials, 92 (N=22,645) provided usable data for meta‐analyses. Regarding relapse prevention, the vast majority of the 31 included treatments outperformed placebo. Compared to placebo, “high” confidence in the results was found for (in descending order of effect magnitude) amisulpride‐oral (OS), olanzapine‐OS, aripiprazole‐LAI, olanzapine‐LAI, aripiprazole‐OS, paliperidone‐OS, and ziprasidone‐OS. “Moderate” confidence in the results was found for paliperidone‐LAI 1‐monthly, iloperidone‐OS, fluphenazine‐OS, brexpiprazole‐OS, paliperidone‐LAI 1‐monthly, asenapine‐OS, haloperidol‐OS, quetiapine‐OS, cariprazine‐OS, and lurasidone‐OS. Regarding tolerability, none of the antipsychotics was significantly worse than placebo, but confidence was poor, with only aripiprazole (both LAI and OS) showing “moderate” confidence levels. Based on these findings, olanzapine, aripiprazole and paliperidone are the best choices for the maintenance treatment of schizophrenia‐spectrum disorders, considering that both LAI and oral formulations of these antipsychotics are among the best‐performing treatments and have the highest confidence of evidence for relapse prevention. This finding is of particular relevance for low‐ and middle‐income countries and constrained‐resource settings, where few medications may be selected. Results from this network meta‐analysis can inform clinical guidelines and national and international drug regulation policies.
MULTI-FEATURE FITTING METHOD OUTPERFORMED DEEP LEARNING METHOD ON DIAGNOSING GASTRIC NEOPLASMS
Authors: Z. Dong, D. Gong, J. Wang, L. Wu, H. Yu
Journal: Endoscopy (2022)

Aims Applying the machine-learning-based multi-feature fitting method to diagnose gastric neoplasms under white light endoscopy. Compare the diagnostic performance of the method with the sole deep-learning-based algorithm.
EUS-GUIDED DIAGNOSIS OF SUBEPITHELIAL GASTROINTESTINAL LESIONS: A MONOCENTRIC EXPERIENCE IN THE ERA OF THE NEW FNB NEEDLES
Authors: M. Sacco, F. Fimiano, A. Mauriello, F. Castellano, M. Gesualdo, F. Cravero, M.T. Staiano, E. Dall'Amico, A. Gambella, S. Gaia, M. Bruno, C.G. De Angelis
Journal: Endoscopy (2022)

Aims Subepithelial lesions (SLs) are found in about 1% of all upper endoscopies; although the majority of them are benign, gastrointestinal stromal tumors (GISTs) have malignant potential and surgery is often needed. Diagnosis of GISTs relies on immunohistochemical staining (IHCS) and achieving adequate tissue from suspected GISTs by EUS-FNA/FNB remains a limitation. Aim of this study is to evaluate diagnostic yield of EUS+FNA/FNB in diagnosis of gastrointestinal SLs.
Endoscopic ultrasound-guided gastroenterostomy versus duodenal stenting: the retrospective story’s been told, now it’s time for a prospective one
Authors: Shayan Irani
Journal: Endoscopy (2022)

Historically, surgical gastrojejunostomy was considered the standard of care for patients with gastric outlet obstruction (GOO) and good functional status, regardless of etiology. Endoscopic placement of a luminal self-expandable metal stent (SEMS) is efficacious and minimally invasive, and remains the widely accepted alternative to surgery for the management of malignant GOO. However, patency of luminal SEMSs due to tumor ingrowth/overgrowth remains a significant limitation. Recently, endoscopic ultrasonography (EUS)-guided gastroenterostomy (EUS-GE) has emerged as a viable alternative to both the above options for malignant and benign etiologies, with early data demonstrating high technical and clinical success and acceptable rates of adverse events [1].
SPYGLASSDS-GUIDED LITHOTRIPSY FOR PANCREATIC DUCT STONES IN SYMPTOMATIC, TREATMENT REFRACTORY CHRONIC PANCREATITIS – LONG-TERM (3-5 YEARS) FOLLOW-UP ON CLINICAL SUCCESS AND QUALITY OF LIFE
Authors: T. Dertmann, P. Siersema, E.-J. Geenen, L. Schmitz, M. Schneider, H. Neuhaus, T. Beyna, C. Gerges
Journal: Endoscopy (2022)

Aims Digital-single-operator-video-pancreatoscopy (d-SOVP) guided lithotripsy was shown to achieve high technical and clinical success rates (95%) in a short-term follow-up(FU). There is only little evidence of mid-and long-term success or impact on quality of life.