tbuckley/cabot-search huggingface dataset:
Routine antenatal care for women and their babies: summary of NICE guidance
Authors: Shalmali Deshpande, Maija Kallioinen, Kate Harding
Journal: BMJ (2021)

### What you need to know Around 660 000 women give birth in England and Wales each year. Antenatal care provides women (and their partners) with support and information about pregnancy, birth, and the postnatal period, and assesses their risk of complications. Even in fit and healthy women, concerns and complications can still arise, and good quality antenatal care can enable women to identify and manage potential problems, to reduce the chance of poor outcomes for both the woman and the baby, and to enhance the woman’s (and her partner’s) experience of pregnancy and childbirth. This new guideline from the National Institute for Health and Care Excellence (NICE)1 replaces the previous version of the NICE guideline on antenatal care published in 2008. This article summarises recommendations from the guideline. We use the terms “woman” or “mother” throughout, but the guidance should be taken to include people who do not identify as women but who are pregnant. ### What is new in this guidance
Aerosol emission from the respiratory tract: an analysis of aerosol generation from oxygen delivery systems
Authors: Fergus W Hamilton, Florence K A Gregson, David T Arnold, Sadiyah Sheikh, Kirsty Ward, Jules Brown, Ed Moran, Carrie White, Anna J Morley, Bryan R Bzdek, Jonathan P Reid, Nicholas A Maskell, James William Dodd
Journal: Thorax (2021)

Introduction continuous positive airway pressure (CPAP) and high-flow nasal oxygen (HFNO) provide enhanced oxygen delivery and respiratory support for patients with severe COVID-19. CPAP and HFNO are currently designated as aerosol-generating procedures despite limited high-quality experimental data. We aimed to characterise aerosol emission from HFNO and CPAP and compare with breathing, speaking and coughing. Materials and methods Healthy volunteers were recruited to breathe, speak and cough in ultra-clean, laminar flow theatres followed by using CPAP and HFNO. Aerosol emission was measured using two discrete methodologies, simultaneously. Hospitalised patients with COVID-19 had cough recorded using the same methodology on the infectious diseases ward. Results In healthy volunteers (n=25 subjects; 531 measures), CPAP (with exhalation port filter) produced less aerosol than breathing, speaking and coughing (even with large &gt;50 L/min face mask leaks). Coughing was associated with the highest aerosol emissions of any recorded activity. HFNO was associated with aerosol emission, however, this was from the machine. Generated particles were small (&lt;1 µm), passing from the machine through the patient and to the detector without coalescence with respiratory aerosol, thereby unlikely to carry viral particles. More aerosol was generated in cough from patients with COVID-19 (n=8) than volunteers. Conclusions In healthy volunteers, standard non-humidified CPAP is associated with less aerosol emission than breathing, speaking or coughing. Aerosol emission from the respiratory tract does not appear to be increased by HFNO. Although direct comparisons are complex, cough appears to be the main aerosol-generating risk out of all measured activities.
TCT-334 Ischemic Mitral Regurgitation Following ST-Elevation Myocardial Infarction: Temporal Trends Over a 20-Year Period
Authors: Leor Perl, Tamir Bental, Katia Orvin, Hana Vaknin-Assa, Gabriel Greenberg, Pablo Codner, Yaron Shapira, Mordehay Vaturi, Ran Kornowski
Journal: Journal of the American College of Cardiology (2021)
Effect of Platelet-Rich Plasma Injections vs Placebo on Ankle Symptoms and Function in Patients With Ankle Osteoarthritis
Authors: Liam D. A. Paget, Gustaaf Reurink, Robert-Jan de Vos, Adam Weir, Maarten H. Moen, Sita M. A. Bierma-Zeinstra, Sjoerd A. S. Stufkens, Gino M. M. J. Kerkhoffs, Johannes L. Tol, Simon Goedegebuure, Rover Krips, Peter A. Nolte, Mario Maas, Duncan E. Meuffels
Journal: JAMA (2021)

<h3>Importance</h3> Approximately 3.4% of adults have ankle (tibiotalar) osteoarthritis and, among younger patients, ankle osteoarthritis is more common than knee and hip osteoarthritis. Few effective nonsurgical interventions exist, but platelet-rich plasma (PRP) injections are widely used, with some evidence of efficacy in knee osteoarthritis. <h3>Objective</h3> To determine the effect of PRP injections on symptoms and function in patients with ankle osteoarthritis. <h3>Design, Setting, and Participants</h3> A multicenter, block-randomized, double-blinded, placebo-controlled clinical trial performed at 6 sites in the Netherlands that included 100 patients with pain greater than 40 on a visual analog scale (range, 0-100) and tibiotalar joint space narrowing. Enrollment began on August 24, 2018, and follow-up was completed on December 3, 2020. <h3>Interventions</h3> Patients were randomly assigned (1:1) to receive 2 ultrasonography-guided intra-articular injections of either PRP (n = 48) or placebo (saline; n = 52). <h3>Main Outcomes and Measures</h3> The primary outcome was the validated American Orthopaedic Foot and Ankle Society score (range, 0-100; higher scores indicate less pain and better function; minimal clinically important difference, 12 points) over 26 weeks. <h3>Results</h3> Among 100 randomized patients (mean age, 56 years; 45 [45%] women), no patients were lost to follow-up for the primary outcome. Compared with baseline values, the mean American Orthopaedic Foot and Ankle Society score improved by 10 points in the PRP group (from 63 to 73 points [95% CI, 6-14];<i>P</i> &lt; .001) and 11 points in the placebo group (from 64 to 75 points [95% CI, 7-15];<i>P</i> &lt; .001). The adjusted between-group difference over 26 weeks was −1 ([95% CI, –6 to 3];<i>P</i> = .56). One serious adverse event was reported in the placebo group, which was unrelated to the intervention; there were 13 other adverse events in the PRP group and 8 in the placebo group. <h3>Conclusions and Relevance</h3> Among patients with ankle osteoarthritis, intra-articular PRP injections, compared with placebo injections, did not significantly improve ankle symptoms and function over 26 weeks. The results of this study do not support the use of PRP injections for ankle osteoarthritis. <h3>Trial Registration</h3> Netherlands Trial Register:NTR7261
TCT-302 Optical Coherence Tomography–Derived Changes in Plaque Structural Stress Over the Cardiac Cycle: A New Method for Plaque Biomechanical Assessment
Authors: Jiayue Huang, Fan Yang, Juan Luis Gutiérrez-Chico, Tianxiao Xu, Jigang Wu, Liang Wang, Rui Lv, Yan Lai, Xuebo Liu, Yoshinobu Onuma, Dalin Tang, Patrick Serruys, William Wijns, Shengxian Tu
Journal: Journal of the American College of Cardiology (2021)
TCT-493 Impact of Established Cardiovascular Disease on 10-Year Death After Coronary Revascularization for Complex Coronary Artery Disease
Authors: Rutao Wang, Scot Garg, Chao Gao, Hideyuki Kawashima, Masafumi Ono, Hironori Hara, Robert-Jan Van Geuns, Marie-Claude Morice, Piroze Davierwala, Arie Kappetein, David Holmes, William Wijns, Ling Tao, Yoshinobu Onuma, Patrick Serruys
Journal: Journal of the American College of Cardiology (2021)
TCT-194 Short- and Long-Term Outcomes With Use of Novel Oral Anticoagulants Versus Standard of Care (Vitamin K Antagonist and/or Antiplatelets) After Transcatheter Aortic Valve Replacement: A Meta-Analysis of 10,404 Procedures
Authors: Sonali Sachdeva, Rupak Desai, Akhil Jain, Harshwardhan Khandait, Hasnan Ijaz, Ahmed Mahmood, Muhammad Uzair Lodhi, Gautam Kumar, Rajesh Sachdeva
Journal: Journal of the American College of Cardiology (2021)
Correction: Regulation of FN1 degradation by p62/SQSTM1-dependent autophagy–lysosomal pathway in HNSCC
Authors: Xinchen Liu, Lin Meng, Xing Li, Daowei Li, Qilin Liu, Yumeng Chen, Xiangwei Li, Wenhuan Bu, Hongchen Sun
Journal: International Journal of Oral Science (2021)
Palliative care and catastrophic costs in Malawi after a diagnosis of advanced cancer: a prospective cohort study
Authors: Maya Jane Bates, Miriam R P Gordon, Stephen B Gordon, Ewan M Tomeny, Adamson S Muula, Helena Davies, Claire Morris, Gerald Manthalu, Eve Namisango, Leo Masamba, Marc Y R Henrion, Peter MacPherson, S Bertel Squire, Louis W Niessen
Journal: The Lancet Global Health (2021)

Inclusive universal health coverage requires access to quality health care without financial barriers. Receipt of palliative care after advanced cancer diagnosis might reduce household poverty, but evidence from low-income and middle-income settings is sparse.
Psychosocial Impact of COVID-19 Pandemic on Patients with ESKD on Peritoneal Dialysis
Authors: Jin Joo Cha, Booyeun Park, Sung Gi Yoon, Dae R. Cha, Young Sun Kang
Journal: Journal of the American Society of Nephrology (2021)

Cha, Jin Joo; Park, Booyeun; Yoon, Sung Gi; Cha, Dae R.; Kang, Young Sun Author Information
Re: Sanad Saad, Nadir I. Osman, Christopher R. Chapple. Female Urethra: Is Ventral the True Dorsal? Eur Urol 2020;78:e218–9
Authors: Sanjay B. Kulkarni, Pankaj M. Joshi, Marco Bandini, Allen F. Morey, Richard A. Santucci, Margit Fisch, Rados Djinovic, Francesco Montorsi, Guido Barbagli, Tony Mundy
Journal: European Urology (2021)
Surgical Volumes and Readiness—Challenges of Declining Cases for the Military Surgeon
Authors: Lesly A. Dossett, Justin B. Dimick
Journal: JAMA Surgery (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
TCT-266 Validation of the Valve Academic Research Consortium 3 Technical Success Definition in Patients Undergoing Transcatheter Aortic Valve Implantation
Authors: Daijiro Tomii, Taishi Okuno, Dik Heg, Jonas Lanz, Fabien Praz, Stefan Stortecky, Stephan Windecker, Thomas Pilgrim
Journal: Journal of the American College of Cardiology (2021)
Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2
Authors: Karthickeyan Chella Krishnan, Laurent Vergnes, Rebeca Acín-Pérez, Linsey Stiles, Michael Shum, Lijiang Ma, Etienne Mouisel, Calvin Pan, Timothy M. Moore, Miklós Péterfy, Casey E. Romanoski, Karen Reue, Johan L. M. Björkegren, Markku Laakso, Marc Liesa, Aldons J. Lusis
Journal: Nature Metabolism (2021)
Patient Characteristics, Treatment Patterns and Outcomes Among Black and White Patients with Multiple Myeloma Initiating Daratumumab: A Real-World Chart Review Study
Authors: Shebli Atrash, Philippe Thompson-Leduc, Ming-Hui Tai, Shuchita Kaila, Kathleen Gray, Isabelle Ghelerter, Marie-Hélène Lafeuille, Patrick Lefebvre, Adriana C Rossi
Journal: Blood (2021)
SUBSTANTIAL RISK OF HEPATOCELLULAR CARCINOMA RECURRENCE EVEN AFTER FIVE YEARS OF NO-RECURRENCE PERIOD AMONG EARLY STAGE HEPATOCELLULAR CARCINOMA PATIENTS TREATED WITH RESECTION OR RADIOFREQUENCY ABLATION
Authors: Kim, J[Kim, Jihye], Kim, GH[Kim, Ga Hee], Kang, W[Kang, Wonseok], Sinn, DH[Sinn, Dong Hyun], Gwak, GY[Gwak, Geum-Youn], Paik, YH[Paik, Yong-Han], Choi, MS[Choi, Moon Seok], Lee, JH[Lee, Joon Hyeok], Koh, KC[Koh, Kwang Cheol], Paik, SW[Paik, Seung Woon]
Journal: Hepatology (2019)
NIHR Alerts aim to help busy health and care professionals put research into practice
Authors: Helen Saul, Cat Chatfield
Journal: BMJ (2021)

Unprecedented extra demands on healthcare staff during the covid-19 pandemic have made it more difficult than ever for professionals to keep up to date with research. This time of major upheaval has underlined the need for health and social care to be the best and most efficient possible. To ensure that changes represent progress, they need to be based on sound research. 

With this in mind, The BMJ is restarting its partnership with the National Institute for Health Research (NIHR). The NIHR is one of the UK’s largest funders of health and care research. It is funded …
Glofitamab Step-up Dosing Induces High Response Rates in Patients (pts) with Relapsed or Refractory (R/R) Mantle Cell Lymphoma (MCL), Most of Whom Had Failed Prior Bruton's Tyrosine Kinase Inhibitor (BTKi) Therapy
Authors: Tycel Phillips, Michael Dickinson, Franck Morschhauser, Emmanuel Bachy, Michael Crump, Marek Trněný, Nancy L. Bartlett, Jan Zaucha, Kathryn Humphrey, David Perez-Callejo, Linda Lundberg, James Relf, Audrey Filézac de L'Étang, David Carlile, Emma Clark, Carmelo Carlo-Stella
Journal: Blood (2021)
Intramuscle fat infiltration in non-dialysis CKD: clinical determinants and association with mortality
Authors: Carla M Avesani, Juliana Giglio, Abdul Rashid T Qureshi, Maria A Kamimura, André Bichels, Peter Stenvinkel, Bengt Lindholm, Juan J Carrero, Antonio C Cordeiro
Journal: Journal of the American Society of Nephrology (2018)
Management of acute pulmonary embolism: towards a (truly) global reach
Authors: Stefano Barco, Luca Valerio
Journal: European Respiratory Journal (2021)

<b>The study by Z. Zhai and colleagues provides an overview of the developments observed as risk-adapted management strategies for acute pulmonary embolism have been progressively introduced and optimised in the Chinese healthcare system</b>https://bit.ly/3swGht2
The histone demethylase Lsd1 regulates multiple repressive gene programs during T cell development
Authors: Daniel B. Stamos, Lauren M. Clubb, Apratim Mitra, Laura B. Chopp, Jia Nie, Yi Ding, Arundhoti Das, Harini Venkataganesh, Jan Lee, Dalal El-Khoury, LiQi Li, Avinash Bhandoola, Remy Bosselut, Paul E. Love
Journal: The Journal of Experimental Medicine (2021)

Analysis of the transcriptional profiles of developing thymocytes has shown that T lineage commitment is associated with loss of stem cell and early progenitor gene signatures and the acquisition of T cell gene signatures. Less well understood are the epigenetic alterations that accompany or enable these transcriptional changes. Here, we show that the histone demethylase Lsd1 (Kdm1a) performs a key role in extinguishing stem/progenitor transcriptional programs in addition to key repressive gene programs during thymocyte maturation. Deletion of Lsd1 caused a block in late T cell development and resulted in overexpression of interferon response genes as well as genes regulated by the Gfi1, Bcl6, and, most prominently, Bcl11b transcriptional repressors in CD4+CD8+ thymocytes. Transcriptional overexpression in Lsd1-deficient thymocytes was not always associated with increased H3K4 trimethylation at gene promoters, indicating that Lsd1 indirectly affects the expression of many genes. Together, these results identify a critical function for Lsd1 in the epigenetic regulation of multiple repressive gene signatures during T cell development.
Longitudinal Plasma Lipidome and Risk of Type 2 Diabetes in a Large Sample of American Indians With Normal Fasting Glucose: The Strong Heart Family Study
Authors: Guanhong Miao, Ying Zhang, Zhiguang Huo, Wenjie Zeng, Jianhui Zhu, Jason G. Umans, Gert Wohlgemuth, Diego Pedrosa, Brian DeFelice, Shelley A. Cole, Amanda M. Fretts, Elisa T. Lee, Barbara V. Howard, Oliver Fiehn, Jinying Zhao
Journal: Diabetes Care (2021)

Comprehensive assessment of alterations in lipid species preceding type 2 diabetes (T2D) is largely unknown. We aimed to identify plasma molecular lipids associated with risk of T2D in American Indians.
Blockade of deubiquitinase YOD1 degrades oncogenic PML/RARα and eradicates acute promyelocytic leukemia cells
Authors: Xuejing Shao, Yingqian Chen, Wei Wang, Wenxin Du, Xingya Zhang, Minyi Cai, Shaowei Bing, Ji Cao, Xiaojun Xu, Bo Yang, Qiaojun He, Meidan Ying
Journal: Acta Pharmaceutica Sinica B (2021)

In most acute promyelocytic leukemia (APL) cells, promyelocytic leukemia (PML) fuses to retinoic acid receptor α (RARα) due to chromosomal translocation, thus generating PML/RARα oncoprotein, which is a relatively stable oncoprotein for degradation in APL. Elucidating the mechanism regulating the stability of PML/RARα may help to degrade PML/RARα and eradicate APL cells. Here, we describe a deubiquitinase (DUB)-involved regulatory mechanism for the maintenance of PML/RARα stability and develop a novel pharmacological approach to degrading PML/RARα by inhibiting DUB. We utilized a DUB siRNA library to identify the ovarian tumor protease (OTU) family member deubiquitinase YOD1 as a critical DUB of PML/RARα. Suppression of YOD1 promoted the degradation of PML/RARα, thus inhibiting APL cells and prolonging the survival time of APL cell-bearing mice. Subsequent phenotypic screening of small molecules allowed us to identify ubiquitin isopeptidase inhibitor I (G5) as the first YOD1 pharmacological inhibitor. As expected, G5 notably degraded PML/RARα protein and eradicated APL, particularly drug-resistant APL cells. Importantly, G5 also showed a strong killing effect on primary patient-derived APL blasts. Overall, our study not only reveals the DUB-involved regulatory mechanism on PML/RARα stability and validates YOD1 as a potential therapeutic target for APL, but also identifies G5 as a YOD1 inhibitor and a promising candidate for APL, particularly drug-resistant APL treatment.
Addressing Imaging Pitfalls to Reduce Cardiovascular Disease Misdiagnosis in Patients With Breast Cancer Following Reconstruction
Authors: Ohad Oren, Ron Blankstein, Deepak L. Bhatt
Journal: JAMA Cardiology (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Gastrointestinal Evaluation of Iron Deficiency Anemia
Authors: Nabil M. Abou Baker, Andrew M. Davis
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Can we do better? Towards a child-centred approach in the rehabilitation of paediatric sport injuries
Authors: Lotte Stausgaard Skrubbeltrang, Niels Nygaard Rossing, Michael Skovdal Rathleff, Jean Côté, Sine Agergaard
Journal: British Journal of Sports Medicine (2021)

The American National SAFE KIDS Campaign estimates that >3.5 million children are injured annually during sports or recreational activities.1 More than 50% of these injuries are overuse injuries. This may be caused by an increased adulteration and professionalisation of youth sport,2 which contributes to children often specialising in one sport at an early age and intensifying their time in sport-specific training. Such augmented volume and frequency of training combined with little time to recovery increase the risk of injuries.3 Evidence shows that injuries may persist and force withdrawal from sport, disrupt friendships, lower quality of life and cause physical impairments in children.4 With a high number of sports-related injuries in children, we need effective and meaningful approaches that integrate child -specific needs and challenges into rehabilitation. The aim of this editorial is to issue a call for action towards child-centred rehabilitation for paediatric patients.

Much of the literature on the treatment of paediatric sports injuries focus on the physical injury with load management, strengthening exercises and consideration of surgical/non-surgical interventions.5 6 …
TCT-360 Comparison of Outcomes Using an Overexpanded Under-sized Versus Nominal-Sized SAPIEN 3 Ultra Transcatheter Heart Valve in Patients With Borderline Annulus Area Based on Computed Tomographic Angiography
Authors: Angela Li, Craig Basman, Denny Wang, Hamfreth Rahming, Lucille Lannan, Paley Arnone, Ahmad Mustafa, Arber Kodra, Luigi Pirelli, Sridhar Uttara, Efstathia Mihelis, Bruce Rutkin, Elana Koss, Sean Wilson, Gregory Maniatis, Mohammed Imam, Puneet Gandotra, Robert Kalimi, Azhar Supariwala, Perwaiz Meraj, Jacob Scheinerman, Chad Kliger
Journal: Journal of the American College of Cardiology (2021)