tbuckley/cabot-search huggingface dataset:
Endothelial cell storage and release of endothelin as a cardioregulatory mechanism.
Authors: GMcClellan, AWeisberg, DRose, SWinegrad
Journal: Circulation Research (1994)

Coronary vascular endothelial cells release substances into the coronary circulation that modify the contractile system of cardiac myocytes, and cardiac myocytes may release factors that modulate the secretion of cardioregulatory substances by endothelial cells. This regulatory loop is sensitive to the rate of coronary flow and tissue oxygen tension. In the present study, coronary venous effluent from isolated perfused hearts and the contents of the coronary vascular endothelial cells have been collected, the latter by disrupting the cells with coronary perfusion at high pressure. The relative amounts of upregulating and downregulating factors in both collections have been estimated by assaying their effects on the contractility of isolated cardiac trabeculas. The amount of upregulating factor stored in the endothelial cells is sensitive to the rate of coronary flow just before disruption of the cells. The quantity of endothelin in the coronary venous effluent and in the vascular endothelial cell contents...
Noninvasive quantitative evaluation of the morphology of the major pulmonary artery branches in cyanotic congenital heart disease. Angiocardiographic and echocardiographic correlative study.
Authors: SHiraishi, HMisawa, HHirota, YAgata, YHoriguchi, NFujino, L HYi, KYashiro, SNakae, MKawada
Journal: Circulation (1994)

BACKGROUNDPrecise noninvasive evaluation of pulmonary artery (PA) morphology is extremely important for medical and surgical management of patients with cyanotic heart disease. In this study, the accuracy of two-dimensional echocardiography combined with color Doppler flow mapping to assess the size, stenosis, and atresia of the major PA branches was examined using a new parasternal approach.METHODS AND RESULTSWith the use of right and left high parasternal windows, we visualized each of the major portions along the right (R-PA) and left (L-PA) pulmonary arteries in 45 of the 47 examinations (96%) in 38 patients with cyanotic heart disease. The patients were between 13 days and 20 years old (mean age, 2.9 years). The internal diameters of the major PA branches were measured at three points along the R-PA (the proximal, mid, and distal portions) and at the proximal and distal portions on the L-PA in systole by both two-dimensional echocardiography and angiography. In addition, the diameter of the stenosis ...
Somatic mutations in lymphocytes in patients with immune-mediated aplastic anemia
Authors: Sofie Lundgren, Mikko A. I. Keränen, Matti Kankainen, Jani Huuhtanen, Gunilla Walldin, Cassandra M. Kerr, Michael Clemente, Freja Ebeling, Hanna Rajala, Oscar Brück, Harri Lähdesmäki, Sari Hannula, Tiina Hannunen, Pekka Ellonen, Neal S. Young, Seishi Ogawa, Jaroslaw P. Maciejewski, Eva Hellström-Lindberg, Satu Mustjoki
Journal: Leukemia (2021)

Abstract The prevalence and functional impact of somatic mutations in nonleukemic T cells is not well characterized, although clonal T-cell expansions are common. In immune-mediated aplastic anemia (AA), cytotoxic T-cell expansions are shown to participate in disease pathogenesis. We investigated the mutation profiles of T cells in AA by a custom panel of 2533 genes. We sequenced CD4+ and CD8+ T cells of 24 AA patients and compared the results to 20 healthy controls and whole-exome sequencing of 37 patients with AA. Somatic variants were common both in patients and healthy controls but enriched to AA patients’ CD8+ T cells, which accumulated most mutations on JAK-STAT and MAPK pathways. Mutation burden was associated with CD8+ T-cell clonality, assessed by T-cell receptor beta sequencing. To understand the effect of mutations, we performed single-cell sequencing of AA patients carrying STAT3 or other mutations in CD8+ T cells. STAT3 mutated clone was cytotoxic, clearly distinguishable from other CD8+ T cells, and attenuated by successful immunosuppressive treatment. Our results suggest that somatic mutations in T cells are common, associate with clonality, and can alter T-cell phenotype, warranting further investigation of their role in the pathogenesis of AA.
Intermittent coronary sinus occlusion after coronary arterial ligation results in venous retroperfusion.
Authors: RBeyar, A DGuerci, H RHalperin, J ETsitlik, M LWeisfeldt
Journal: Circulation Research (1989)

Coronary sinus occlusion retards necrosis of ischemic myocardium. To test the hypothesis that coronary sinus occlusion induces retrograde venoarterial flow, the coronary arteriovenous pressure gradient and the coronary arterial oxygen saturation were measured distal to a left anterior descending coronary artery ligature in dogs. In parallel, we constructed a mathematical model of known coronary physiology to characterize pressure and flow patterns during coronary sinus occlusion. In dogs, coronary sinus occlusion produced a systolic pressure gradient between the coronary artery and the coronary sinus of -20 +/- 9 mm Hg (higher venous pressure, p less than 0.0001) and a positive diastolic gradient of 3 +/- 5 mm Hg (lower venous pressure p less than 0.01). An average reduction in the oxygen saturation in the ligated coronary artery of 20 +/- 13% was also observed (p less than 0.005) consequent to admixture of venous (desaturated) blood. By graded inflation of the coronary sinus balloon, it was demonstrated ...
Letter to the editor: Distinguishing between hantavirus-induced haemorrhagic fever with renal syndrome and pregnancy-induced liver pathologies (AFLP and HELLP syndromes)
Authors: J Clement, V Vergote, L Laenen, M Van Ranst
Journal: Eurosurveillance (2013)

Preview this article: Letter to the editor: Distinguishing between hantavirus-induced haemorrhagic fever with renal syndrome and pregnancy-induced liver pathologies (AFLP and HELLP syndromes), Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/18/22/art20493-en-1.gif
Reentrant ventricular arrhythmias in the late myocardial infarction period. 6. Effect of the autonomic system.
Authors: NEl-Sherif
Journal: Circulation (1978)

The effect of the autonomic system on conduction disorders in the infarction zone (IZ) and related reentrant ventricular arrhythmias (RVA) in the late myocardial infarction period in the dog was studied utilizing averaged recordings of the reentrant pathways from the epicardial surface of the IZ. Vagal (V) stimulation was found to have no significant direct electrophysiologic effect while sympathetic (S) stimulation resulted in a direct slight improvement of conduction in the IZ. However, because of the marked rate-dependency of conduction in the IZ, the effects of both V and S stimulation were modified through changes in the heart rate. The bradycardia produced by V stimulation resulted in improvement of conduction in the IZ and disappearance of RVA, while the tachycardia induced by S stimulation resulted in worsening of conduction in the IZ and the occurrence of RVA. Thus, in spite of its slight enhancing effect on conduction in the IZ, the propensity of S stimulation to induce RVA was primarily due to ...
Risk Factors for Metachronous Lesions After Gastric Endoscopic or Surgical Resection - A Systematic Review And Meta-Analysis
Authors: R Ortigão, G Figueirôa, P Pimentel-Nunes, M Dinis-Ribeiro, D Libânio
Journal: Endoscopy (2021)

Aims Metachronous gastric lesions (MGL) is a major concern after curative resection of early gastric cancer (EGC) by endoscopic resection (ER) or partial gastrectomy (PG), and endoscopic surveillance is needed after treatment. Risk factors for its development could help in individualizing surveillance schedule, but are controversial in literature. Our aim was to identify significant risk factors for MGL and compare the incidence of MGC after ER and PG.
T-type Ca2+ channels are abnormal in genetically determined cardiomyopathic hamster hearts.
Authors: LSen, T WSmith
Journal: Circulation Research (1994)

Although there is substantial evidence of abnormal Ca2+ homeostasis in heart cells of the cardiomyopathic Syrian hamster (Bio 14.6 strain), the mechanism by which these myocytes become Ca(2+)-overloaded is not known. To elucidate the role of voltage-sensitive Ca2+ channels in the pathogenesis of myopathy, whole-cell Ca2+ currents were measured in myopathic and normal control cardiac myocytes. These studies demonstrate the presence of two voltage-sensitive Ca2+ channel types in ventricular myocytes isolated from 200- to 300-day-old cardiomyopathic and age-matched normal hamsters. The two Ca2+ channel types were identified by their unitary conductance properties and pharmacologic sensitivities. Both L-type and T-type Ca2+ channels were present in cardiomyopathic and normal cells. Current density through L-type Ca2+ channels was the same in cardiomyopathic and normal control myocytes. However, the mean current density of T-type Ca2+ channels in cardiomyopathic cells was significantly higher than in normal ce...
Shortening of fast pathway refractoriness after slow pathway ablation. Effects of autonomic blockade.
Authors: ANatale, GKlein, RYee, RThakur
Journal: Circulation (1994)

BACKGROUNDShortening of the anterograde effective refractory period (ERP) of the fast pathway has been reported after radiofrequency ablation of the slow pathway. We hypothesized that ERP shortening may be related to autonomic changes, possibly catecholamine release, as a result of ablation.METHODS AND RESULTSTo test this, 10 consecutive patients with atrioventricular node reentry undergoing slow pathway ablation were given autonomic blockade before the ablation procedure. This was achieved by atropine 0.03 mg/kg and propranolol 0.15 mg/kg IV supplemented by half the initial dose after ablation and before the final study. A control group of 10 patients underwent the protocol without autonomic blockade. Before ablation, autonomic blockade did not alter the ERP of either the fast pathway (295 +/- 22 versus 298 +/- 26 milliseconds) or the slow pathway (264 +/- 36 versus 269 +/- 38 milliseconds). Autonomic blockade obscured dual pathway physiology in 2 patients and brought it out in another 2 without dual pat...
Effects of sympathetic tone on vagally induced phasic changes in heart rate and atrioventricular node conduction in the anesthetized dog.
Authors: J JSalata, R MGill, R FGilmour, D PZipes
Journal: Circulation Research (1986)

We examined the effects of stellate ganglia stimulation on the phase-dependent chronotropic and dromotropic responses to brief vagal bursts in open-chest anesthetized dogs. Stellate stimulation affected the phasic vagal effects on heart rate by shortening the latent period, shifting the phase at which maximum decrease in heart rate occurred to earlier phases, and reducing the maximum decrease in heart rate. These effects were due primarily to an increase in the basic heart rate. No significant sympathetic-parasympathetic interaction occurred for heart rate, indicating that accentuated antagonism did not occur with brief vagal bursts. Stellate stimulation primarily decreased the amplitude of the phasic vagal effects on atrioventricular nodal conduction, regardless of the underlying heart rate, and a significant sympathetic-parasympathetic interaction was associated with this effect. The peak of the phase-dependent vagal effects on heart rate and atrioventricular nodal conduction were phase-shifted with one...
Comment on “Interruption of oral clindamycin plus rifampicin therapy in patients with hidradenitis suppurativa: An observational study to assess prevalence and causes”
Authors: Claudio Marasca, Anna Masarà, Maria Carmela Annunziata, Davide Fattore, Gabriella Fabbrocini
Journal: Journal of the American Academy of Dermatology (2019)
Re: Niels J. van Casteren, Hans Stoop, Gert R. Dohle, Ronald de Wit, J. Wolter Oosterhuis, Leendert H.J. Looijenga. Noninvasive Detection of Testicular Carcinoma In Situ in Semen Using OCT3/4. Eur Urol 2008;54:153–60
Authors: Klaus-Peter Dieckmann
Journal: European Urology (2008)
Small Bowel Capsule Endoscopy, Systematic Review and Pairwise Meta- Analysis: the Key Point is the Timing
Authors: C Marmo, A Tortora, G Costamagna, ME Riccioni
Journal: Endoscopy (2021)

Aims The aim of the current study is to evaluate the preparation type and the modality of administration to provide an adequate small bowel cleansing in patients undergoing small bowel capsule endoscopy.
Differential effects of pH on calcium activation of myofilaments of adult and perinatal dog hearts. Evidence for developmental differences in thin filament regulation.
Authors: R JSolaro, PKumar, E MBlanchard, A FMartin
Journal: Circulation Research (1986)

Our results show that calcium activation of myofilament preparations of dog heart in the perinatal period is unaffected by a reduction in pH from 7.0 to 6.5, which, in adult heart myofilaments, induces a 0.4 pCa unit (-log molar free calcium concentration) rightward shift in the relation between pCa and myofibrillar adenosine triphosphatase activity. Acidic pH also had no effect on calcium binding to myofibrillar troponin C of perinatal hearts. The stoichiometry of troponin C bound calcium at full myofilament activation (about 3 mol calcium/mol troponin C) was the same for adult and perinatal heart myofibrils, as was their myofibrillar troponin C content. Moreover, there were no differences in isoelectric pH of troponin C from adult and perinatal hearts. We tested whether variants of myofilament proteins other than troponin C could account for the differential effects of acidic pH. In adult and perinatal dog heart preparations, myosin heavy chain isoenzymes appeared the same as measured, using native pyro...
Right atrial myxoma: unusual clinical presentation and atypical glandular histology.
Authors: WFrishman, SFactor, AJordan, CHellman, UElkayam, TLeJemtel, JStrom, HUnschuld, RBecker
Journal: Circulation (1979)

A 57-year-old black female presented with a 1-month of right-sided congestive heart failure and clinical evidence of pulmonic and tricuspid valvular stenosis and insufficiency. The echocardiographic examination and ventriculography demonstrated a large right atrial tumor interfering with the function of both right-sided valves. The patient underwent successful surgical resection of the tumor. Histologically, the tumor had cellular areas typical of myxoma, as well as glandular areas, a feature which has been described very rarely in this lesion. Electron microscopy of the glandular zones, which has never been reported previously, shown cells having essential homology with the usual myxoma elements. The atypical histopathology of this lesion supports the theory that atrial myxomas are true neoplasms, and are not derived from unusually organized mural thrombi.
Results of ophthalmosonometry and supraorbital photoplethysmography in evaluating carotid arterial stenoses.
Authors: L JDuke, E ESlaymaker, W CLamberth, C BWright
Journal: Circulation (1979)

A total of 263 patients underwent either periorbital ophthalmosonometry (Doppler ultrasound) or a combination of ophthalmosonometry and supraorbital photoplethysmography (SOPPG) to determine the presence or absence of a hemodynamically significant lesion (occlusion or greater than 50% reduction in lumen diameter). There were 522 vessels studied with Doppler ultrasound and 272 vessels with a combination of the two modalities. The tests were correlated with carotid arteriography to determine their accuracy. Overall accuracy of the Doppler ultrasound examination was 95%. A normal Doppler ultrasound examination was obtained in 367 vessels and arteriography confirmed the absence of a hemodynamically significant lesion in 93%. Of 155 vessels with an abnormal Doppler examination, 149 (96%) were proven on arteriography to have hemodynamically significant lesions. The Doppler ultrasound examination had a high incidence of false-negative examinations (26%) in those vessels that were between 50% and 99% stenotic, ho...
The effect of graded coronary flow reduction in the left anterior descending and septal arteries on left ventricular function in the canine heart.
Authors: YKoiwa, TNunokawa, NIshide, SIsoyama, SKitaoka, KTamaki, SSatoh, HSuzuki, YShimizu, YKakuta, EIno-Oka, TTakishima
Journal: Circulation (1980)

WE quantitatively analyzed the effect of graded left anterior descending and septal coronary flow (LAD + septal flow) reduction on left ventricular function with a left ventricular end-diastolic pressure (LVEDP) of 6 mm Hg and 12 mm Hg. We used an isolated, ejecting, canine heart preparation ( n = 8), the coronary flow of which could be controlled independently of the aortic pressure. We kept the other hemodynamic variables - heart rate, left circumflex coronary flow, right coronary flow and aortic input impendance - constant within their normal physiologic range. We considered this reduction in LAD + septal flow to be analogous to that of the most frequent lesion in ischemic heart disease. There was no plateau in the left ventricular work caused by this reduction of the regional coronary flow. Therefore, the plateau commonly reported in previous studies may be partially a result of the compensatory elevation of LVEDP, which is necessary to maintain the left ventricular work.
Cystic Neoplasms of the Pancreas
Authors: William R. Brugge, Gregory Y. Lauwers, Dushyant Sahani, Carlos Fernandez-del Castillo, Andrew L. Warshaw
Journal: New England Journal of Medicine (2004)

Owing to improvements in imaging techniques, cystic lesions of the pancreas are being identified more often, even in patients who are asymptomatic. These lesions range from benign to premalignant to highly malignant. This review offers guidance on the strategies for establishing the diagnosis, assessing risk, and making difficult decisions about when surgical resection is indicated.
Interaction between angiotensin II and the baroreceptor reflex in the control of adrenocorticotropic hormone secretion and heart rate in conscious dogs.
Authors: V LBrooks, I AReid
Journal: Circulation Research (1986)

The present studies were designed to examine the effect of angiotensin II on baroreflex control of adrenocorticotropic hormone secretion and heart rate in conscious dogs. Baroreflex function was assessed by examining the relationship between blood pressure and plasma corticosteroid concentration (used as an index of adrenocorticotropic hormone secretion) and between blood pressure and pulse interval (the inverse of heart rate). Blood pressure was varied by intravenous infusion of four doses (0.3, 0.6, 1.5, and 3.0 micrograms/kg per min) of the vasodilator nitroprusside. Nitroprusside infusion produced an increase in plasma corticosteroid concentration and a decrease in pulse interval, both of which were linearly related to the fall in arterial blood pressure. During infusion of angiotensin II (10 ng/kg per min), however, the lines relating blood pressure to plasma corticosteroid concentration or blood pressure to pulse interval were shifted to a higher pressure level, suggesting that angiotensin II resets...
A cause of paired ventricular extrasystoles.
Authors: SKinoshita, KFujita, KKanda, YTanabe, TKawasaki
Journal: Circulation (1979)

Eight patients with ventricular extrasystoles are reported in whom coupling intervals of the extrasystoles to the proceding sinus beats were variable and in whom paired ventricular extrasystoles were occasionally seen. In all patients, paired ventricular extrasystoles were initiated only by comparatively late coupled ventricular extrasystoles. However, the interval between the first and the second of these paired extrasystoles was always much shorter than the coupling interval of this first extrasystole to the preceding sinus beat, so that the latter extrasystole often interrupted the T wave of the first one, indicating the R-on-T phenomenon. In two patients there was a gap between the ranges of coupling intervals for single extrasystoles and for the first ones of paired extrasystoles. These observations suggest the presence of longitudinal dissociation in the reentrant pathway as one of the causes of paired ventricular extrasystoles.
Detection and quantitation of constriction of the fetal ductus arteriosus by Doppler echocardiography.
Authors: J CHuhta, K JMoise, D JFisher, D SSharif, NWasserstrum, CMartin
Journal: Circulation (1987)

Pulmonary hypertension may occur in the fetus in the presence of constriction of the ductus arteriosus. The feasibility of detection and quantitation of fetal ductal constriction by Doppler echocardiography was assessed in an animal preparation in which ductal constriction was created in the fetal lamb with a variable ligature causing varying degrees of fetal pulmonary hypertension (fetal pulmonary arterial systolic pressure 57 to 97 mm Hg and ductal gradient 9 to 42 mm Hg). Comparison of blinded, continuous-wave peak Doppler velocity (V) measurements of the ductal gradient with the modified Bernoulli assumption (gradient = 4V2) compared well with direct catheter measurements of instantaneous peak systolic gradient (r = .99, catheter = 0.95 X Doppler + 0.6), peak-to-peak gradient (r = .97), and mid-diastolic gradient (r = .85). Ductal constriction was characterized by an increase in the peak systolic and diastolic velocities. The normal human fetal ductus arteriosus blood flow velocity pattern was assesse...
Real-time and simultaneous measurement of tricuspid orifice and tricuspid anulus areas in anesthetized dogs.
Authors: KTamiya, MHigashidate, SKikkawa
Journal: Circulation Research (1989)

Tricuspid valve orifice and tricuspid valve anulus areas were measured simultaneously in the anesthetized dog with a newly developed area-measuring system based on electromagnetic induction. This system permitted real-time monitoring of the area enclosed by the edges of valve leaflets and by the juncture of the valve leaflet and the cardiac wall in situ, without artificial constraint to the valve motion. Right atrial and right ventricular pressures were measured with two catheter-tipped micromanometers. During control state, tricuspid valve orifice area (TOA) increased up to its peak [1.38 +/- 0.26 cm2 (mean +/- SD)] coincidently with either atrial systole or rapid ventricular filling. Atrial contraction evoked distinct presystolic tricuspid anulus narrowing with concomitant slow TOA reduction. This slow TOA reduction began 30.0 +/- 16.1 msec before systolic atrioventricular pressure crossover, and the following rapid TOA decrease was completed 38.7 +/- 12.2 msec after systolic atrioventricular pressure c...
Reply to: Subclinical renal dysfunction is independently associated with cardiovascular events in rheumatoid arthritis: the CARRÉ Study
Authors: Tomoyuki Kawada
Journal: Annals of the Rheumatic Diseases (2012)

I read with great interest the paper by van Sijl et al ,1 a 3-year longitudinal study by following patients with rheumatoid arthritis (RA) to know the effect of the estimated renal function on cardiovascular (CV) events. Out of 330 participants, 23 had a CV event (7%). They mentioned the study limitation of low statistical power derived from the small number of CV events, and the restriction of confounding variables for the analysis. This limitation reflects on the number of independent variables in their study presented in Table 2. Furthermore, …