tbuckley/cabot-search huggingface dataset:
Abstract P274: Cross-sectional Analysis of Baseline Characteristics for New Users of Vorapaxar (PAR-1 Antagonist) and P2Y <sub>12</sub> Inhibitors
Authors: Cathy Anne Pinto, Gregory P. Hess, Eileen Fonseca, John Acquavella
Journal: Circulation (2018)

Introduction: Vorapaxar is indicated for the reduction of thrombotic events in patients with a prior myocardial infarction (MI) or peripheral arterial disease (PAD), and contraindicated in patients with a prior stroke, transient ischemic attack (TIA), or intracranial hemorrhage (ICH). This is the first descriptive study of vorapaxar in US clinical practice. Objectives: Main objective was to describe baseline characteristics of vorapaxar new users. For context, P2Y 12 new users were also examined, with indications summarized in Table 1. Methods: Cross-sectional analysis of vorapaxar new users ≥18 years with ≥1 prescription between June 2014 - June 2016 identified in Symphony Health’s outpatient pharmacy claims database linked to private practitioner claims and hospital data. Concomitant clopidogrel use was defined with overlapping days of supply. Medical history was defined using a 1-year baseline period. Results: The analysis included 1,362 vorapaxar (44% with clopidogrel), 975,023 clopidogrel, 133,724 ticagrelor, and 98,101 prasugrel new users (Table 1). Most ticagrelor (87%) and prasugrel (85%) users had evidence of coronary artery disease (CAD) compared with 52% of clopidogrel and 58% of vorapaxar users. In contrast, &lt;1% of ticagrelor and prasugrel users had PAD but no CAD vs. 6% of clopidogrel and 15% of vorapaxar users. The proportion of vorapaxar users (44%) with PAD, alone or with CAD, was 3-5 times larger than P2Y 12 users. PAD was more prevalent for vorapaxar with (50%) vs. without (39%) clopidogrel. Contraindications were infrequent for vorapaxar users - no ICH, &lt;4% with stroke or TIA. Median time from recent MI to therapy start was 6 months for vorapaxar vs. 3 days for ticagrelor and prasugrel and 7 days for clopidogrel. Vorapaxar users were mostly male and on average ~65 years old. Conclusions: The majority of vorapaxar new users had a history of CAD and/or PAD, with PAD prevalence more than twice that of P2Y 12 new users. Contraindications were infrequent.
Cystic Hepatic Neuroendocrine Tumor
Authors: Fabian Haupt, Ali Afshar-Oromieh, Verena Carola Obmann, Adrian Thomas Huber, Martin Maurer
Journal: Clinical Nuclear Medicine (2021)

Abstract A 70-year-old man presented with unspecific abdominal symptoms and weight loss was referred for a sonographic examination. Sonography revealed 3 cystic hepatic masses in an otherwise unremarkable liver. Contrast-enhanced MRI of the liver was performed to characterize the hepatic lesions and elucidate their etiology. The differential diagnosis was primarily parasitic disease or metastases with cystic transformations. 68 Ga-DOTATOC PET/CT revealed the neuroendocrine origin of these lesions, confirmed by biopsy. However, the primary site of the neuroendocrine tumor remained unclear, leaving primary hepatic neuroendocrine tumor and neuroendocrine cancer of unknown primary as possible diagnostic options.
Antibodies against viral nucleo-, phospho-, and X protein contribute to serological diagnosis of fatal Borna disease virus 1 infections
Authors: Bernhard Neumann, Klemens Angstwurm, Ralf A. Linker, Gertrud Knoll, Lisa Eidenschink, Dennis Rubbenstroth, Kore Schlottau, Martin Beer, Patrick Schreiner, Erwin Soutschek, Merle M. Böhmer, Benedikt M.J. Lampl, Matthias Pregler, Alexander Scheiter, Katja Evert, Saida Zoubaa, Markus J. Riemenschneider, Benedikt Asbach, André Gessner, Hans Helmut Niller, Barbara Schmidt, Markus Bauswein
Journal: Cell Reports Medicine (2022)

Borna disease virus 1 (BoDV-1) causes rare but often fatal encephalitis in humans. Late diagnosis prohibits an experimental therapeutic approach. Here, we report a recent case of fatal BoDV-1 infection diagnosed on day 12 after hospitalization by detection of BoDV-1 RNA in the cerebrospinal fluid. In a retrospective analysis, we detect BoDV-1 RNA 1 day after hospital admission when the cell count in the cerebrospinal fluid is still normal. We develop a new ELISA using recombinant BoDV-1 nucleoprotein, phosphoprotein, and accessory protein X to detect seroconversion on day 12. Antibody responses are also shown in seven previously confirmed cases. The individual BoDV-1 antibody profiles show variability, but the usage of three different BoDV-1 antigens results in a more sensitive diagnostic tool. Our findings demonstrate that early detection of BoDV-1 RNA in cerebrospinal fluid and the presence of antibodies against at least two different viral antigens contribute to BoDV-1 diagnosis. Physicians in endemic regions should consider BoDV-1 infection in cases of unclear encephalopathy and initiate appropriate diagnostics at an early stage.
Endogenous Anorectic Agents--Satietins
Authors: J Knoll
Journal: The Annual Review of Pharmacology and Toxicology (1988)

Over the past two decades, deadly coronaviruses, with the most recent being the severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) 2019 pandemic, have majorly challenged public health. The path for virus invasion into humans and other ...Read More
A new public health world order
Authors: None The Lancet Infectious Diseases
Journal: The Lancet Infectious Diseases (2004)

The International Health Regulations (IHR) have long been considered to be an inadequate tool for policing international public health. As far back as 1969 the then WHO Deputy Director-General pronounced the IHR's legal duties "a dead letter". Now in the process of revision, and the subject of six regional WHO meetings in mid-June, can the IHR keep pace with modern global public health governance?
Erratum
Journal: BMJ (1906)

urine is excreted.Under such circumstances, pure blood or blood clot may be passed through the mouth of the ureter, or pus may escape in putty-like bands which issue slowly from the ureter.When haemorrhage takes place into the pelvis of the kidney, and the blood is retained there for a considerable time, it becomes so altered that it does not mix freely with the contents of the bladder.When it passes from the ureter it may appear like a ribbon or band of melted red wax, which flows slowly from the mouth, and, after it has attained a certain length, breaks off and floats away.
Table of Contents
Authors: Mayra Maymone, Melissa Laughter, Samantha Venkatesh, Mara Dacso, P Rao, Barbara Stryjewska, Jeremy Hugh, Robert Dellavalle, Cory Dunnick, Rana Abdat, Dirk Elston, Warren Heymann, Shamir Geller, Andrea Chiricozzi, Martina Maurelli, Niccolo Gori, Giuseppe Argenziano, Clara De Simone, Giulia Calabrese, Giampiero Girolomoni, Ketty Peris, Reid Waldman, Valeria De Bedout, Annette Czernik, Michael Mcleod, Brett King, Samantha Gordon, Razzaque Ahmed, Anna Nichols, Marti Rothe, David Rosmarin, Takashi Hashimoto, Christina Kursewicz, Rachel Fayne, Sonali Nanda, Serena Shah, Leigh Nattkemper, Hiroo Yokozeki, Gil Yosipovitch, Michelle Min, Jianni Wu, Helen He, Juan Luis Sanz-Cabanillas, Ester Duca, Ning Zhang, Yael Renert-Yuval, Ana Pavel, Mark Lebwohl, Emma Guttman-Yassky, Jeffrey Hu, Steven Billings, Di Yan, Anthony Fernandez, Andrew Song, Ashley Gochoco, Tingting Zhan, Joya Sahu, Onder Alpdogan, Pierluigi Porcu, Neda Nikbakht, Wenyin Shi, Shannon Humphrey, Derek Jones, Jean Carruthers, Alastair Carruthers, Katie Beleznay, Naissan Wesley, Jeanette Black, Sherri Vanderveen, Ardalan Minokadeh, Abby Van Voorhees, Linda Gold, Bruce Strober, Charles Lynde, Stephen Tyring, Ashley Cauthen, Howard Sofen, Zuoshun Zhang, Maria Paris, Yao Wang, John Barbieri, Andrea Roe, Arash Mostaghimi, Ryoji Tsuboi, Shiro Niiyama, Ryokichi Irisawa, Kazutoshi Harada, Yosuke Nakazawa, Jiro Kishimoto, Kimberly Bowerman, David Med, Joyce Pearson, Victoria Okawa, Alexandra Vent, Christian Surber, Phil Nat, Nicole Graf Johansen, Verena Figueiredo, Georg Scho¨nba¨chler, Laurence Imhof, Caroline Buset, J€ Urg Hafner, Murad Alam, Brandon Worley, Rohit Gupta, Marina Ibraheim, Hung Doan, Ha Kong, Jane Grant-Kels, Benjamin Stoff, Leo Wang, Ata Moshiri, Roberto Novoa, Cory Simpson, Junko Takeshita, Aimee Payne, Emily Chu, Elliott Campbell, Chad Straughan, Diana Antonovich, Karyn Haitz, Hasan Khosravi, Jennifer Lin, Tyler Menge, Vinod Nambudiri, Meera Jain, Kavita Goyal, Daniel O'leary, Nathan Rubin, Kimberly Bohjanen, Amrita Goyal, Arianne Kourosh, Lynda Schneider, Elena Hawryluk, Lana Tong, Corinna Rea, Joseph Kvedar, Solomon Geizhals, Victoria Cooley, Shari Lipner, Charlotte Bernigaud, Deepani Fernando, Hieng Lu, Sara Taylor, Gunter Hartel, Olivier Chosidow, Katja Fischer, Laurent Misery, Jason Shourick, Charles Taieb, Ariana Ellis, Urmi Khanna, Abdulaziz Galadari, Sujay Khandpur, Prateek Sondhi, Neha Taneja, Preeti Sharma, Dayasagar Das, Alpana Sharma, Vishnubatla Sreenivas, Robin Rolader, Lauren Daugherty, Yuan Liu, Ron Feldman, Teo Soleymani, Susan Swetter, S Hollmig, Sumaira Aasi, Partik Singh, Jonathan Silverberg
Journal: Journal of the American Academy of Dermatology (2020)
Journal Club
Authors: James Kent Bramer
Journal: Thorax (2020)

DeteCting lung CanCer using exhaleD breath analysisVolatile organic compounds (VOC) in the breath have been identified as potential biomarkers of lung cancer.Phillips and colleagues (J Breath Res 2019;13:036013) investigated whether a breath VOC biomarker of lung cancer could also predict pulmonary nodules on low-dose chest CT (LDCT).The study enrolled patients undergoing LDCT screening for lung cancer.The initial phase employed an unblinded analysis of the exhaled breath of 301 subjects.Analysis identified a mass ion biomarker, termed mass abnormalities in gaseous ions with imaging correlates (MAGIIC).Crossreferencing with a library of mass spectra, it appeared MAGIIC may be related to metabolic products of oxidative stress.Subsequent blinded validation in a separate group of 161 lung cancer screening participants demonstrated optimum sensitivity and specificity for biopsy-proven lung cancer of 75% and 85%, respectively.Accuracy for pulmonary nodules was 77% and 81%, based on analysis from two separate laboratories.The level of MAGIIC in breath was not significantly affected by smoking history.MAGIIC and other similar biomarkers may be useful as a supplement to LDCT to assess the likelihood that a pulmonary nodule is malignant.
Medicolegal.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Grass-roots entrepreneurship complements traditional top-down innovation in lung and breast cancer
Authors: Khalil B. Ramadi, Rhea Mehta, David He, Sichen Chao, Zen Chu, Rifat Atun, Freddy T. Nguyen
Journal: npj Digital Medicine (2022)

The majority of biomedical research is funded by public, governmental, and philanthropic grants. These initiatives often shape the avenues and scope of research across disease areas. However, the prioritization of disease-specific funding is not always reflective of the health and social burden of each disease. We identify a prioritization disparity between lung and breast cancers, whereby lung cancer contributes to a substantially higher socioeconomic cost on society yet receives significantly less funding than breast cancer. Using search engine results and natural language processing (NLP) of Twitter tweets, we show that this disparity correlates with enhanced public awareness and positive sentiment for breast cancer. Interestingly, disease-specific venture activity does not correlate with funding or public opinion. We use outcomes from recent early-stage innovation events focused on lung cancer to highlight the complementary mechanism by which bottom-up "grass-roots" initiatives can identify and tackle under-prioritized conditions.
N4-acetyldeoxycytosine DNA modification marks euchromatin regions in Arabidopsis thaliana
Authors: Shuai Wang, Hairong Xie, Fei Mao, Haiyan Wang, Shu Wang, Zhenglin Chen, Yuxia Zhang, Zhihui Xu, Jinming Xing, Zhaokang Cui, Xiquan Gao, Hongmei Jin, Jian Hua, Bo Xiong, Yufeng Wu
Journal: Genome biology (2022)

Abstract Background Direct analogs of chemically modified bases that carry important epigenetic information, such as 5-methylcytosine (m5C)/5-methyldeoxycytosine (5mC), 5-hydroxymethylcytosine (hm5C)/5-hydroxymethyldeoxycytosine (5hmC), and N 6 -methyladenosine (m6A)/ N 6 -methyldeoxyadenosine (6mA), are detected in both RNA and DNA, respectively. The modified base N 4 -acetylcytosine (ac4C) is well studied in RNAs, but its presence and epigenetic roles in cellular DNA have not been explored. Results Here, we demonstrate the existence of N 4 -acetyldeoxycytosine (4acC) in genomic DNA of Arabidopsis with multiple detection methods. Genome-wide profiling of 4acC modification reveals that 4acC peaks are mostly distributed in euchromatin regions and present in nearly half of the expressed protein-coding genes in Arabidopsis . 4acC is mainly located around transcription start sites and positively correlates with gene expression levels. Imbalance of 5mC does not directly affect 4acC modification. We also characterize the associations of 4acC with 5mC and histone modifications that cooperatively regulate gene expression. Moreover, 4acC is also detected in genomic DNA of rice, maize, mouse, and human by mass spectrometry. Conclusions Our findings reveal 4acC as a hitherto unknown DNA modification in higher eukaryotes. We identify potential interactions of this mark with other epigenetic marks in gene expression regulation.
JAMA Reference Directories
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cigarette Smoking Among Adults—United States, 1998
Journal: JAMA (2000)

WORLD HEALTH ASSEMbly resolved to eradicate poliomyelitis globally by 2000. 1 Following the signing of the Yaounde Declaration on Polio Eradication in Africa in 1996, Ethiopia joined global efforts toward polio eradication. 2Since then, Ethiopia has accelerated implementation of polio eradication strategies.This report summarizes progress toward polio eradication in Ethiopia during 1997-August 2000 and highlights the remaining challenges toward achieving the goal. Routine Vaccination CoverageDuring 1990-1999, reported coverage of children aged 0-11 months with 3 doses of oral poliovirus vaccine (OPV3) ranged from 20%-90%.The last comprehensive coverage survey conducted in 1995 estimated OPV3 coverage at 36%.Preliminary data from the 2000 Ethiopia Demographic and Health Survey estimates average OPV3 coverage at 35%.
CCT3-<i>LINC00326</i>axis regulates hepatocarcinogenic lipid metabolism
Authors: Jonas Nørskov Søndergaard, Christian Sommerauer, Ionut Atanasoai, Laura C Hinte, Keyi Geng, Giulia Guiducci, Lars Bräutigam, Myriam Aouadi, Lovorka Stojic, Isabel Barragan, Claudia Kutter
Journal: Gut (2022)

Objective To better comprehend transcriptional phenotypes of cancer cells, we globally characterised RNA-binding proteins (RBPs) to identify altered RNAs, including long non-coding RNAs (lncRNAs). Design To unravel RBP-lncRNA interactions in cancer, we curated a list of ~2300 highly expressed RBPs in human cells, tested effects of RBPs and lncRNAs on patient survival in multiple cohorts, altered expression levels, integrated various sequencing, molecular and cell-based data. Results High expression of RBPs negatively affected patient survival in 21 cancer types, especially hepatocellular carcinoma (HCC). After knockdown of the top 10 upregulated RBPs and subsequent transcriptome analysis, we identified 88 differentially expressed lncRNAs, including 34 novel transcripts. CRISPRa-mediated overexpression of four lncRNAs had major effects on the HCC cell phenotype and transcriptome. Further investigation of four RBP-lncRNA pairs revealed involvement in distinct regulatory processes. The most noticeable RBP-lncRNA connection affected lipid metabolism, whereby the non-canonical RBP CCT3 regulated LINC00326 in a chaperonin-independent manner. Perturbation of the CCT3- LINC00326 regulatory network led to decreased lipid accumulation and increased lipid degradation in cellulo as well as diminished tumour growth in vivo . Conclusions We revealed that RBP gene expression is perturbed in HCC and identified that RBPs exerted additional functions beyond their tasks under normal physiological conditions, which can be stimulated or intensified via lncRNAs and affected tumour growth.
TCTAP A-081 Percutaneous Coronary Intervention vs. Coronary Artery Bypass Graft for Multi-Vessel Coronary Artery Disease in Patients with Chronic Renal Failure and Renal Replacement Therapy
Authors: Se Hun Kang, Seung-Jung Park, Seong-Wook Park, Cheol Whan Lee, Young-Hak Kim, Seung-Whan Lee, Duk-Woo Park, Soo-Jin Kang, Jung-Min Ahn, Pil Hyung Lee, Cheol Hyun Lee, Min Soo Cho, Jae Seok Bae, Yu Na Kim, Sung Han Yoon, Do-Yoon Kang, Mineok Chang
Journal: Journal of the American College of Cardiology (2016)
Unsung Hero
Authors: Lola Oberman
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pathophysiological pathways related to high plasma growth differentiation factor 15 concentrations in patients with heart failure
Authors: Daan Ceelen, Adriaan A. Voors, Jasper Tromp, Dirk J. van Veldhuisen, Kenneth Dickstein, Rudolf A. de Boer, Chim C. Lang, Stefan D. Anker, Leong L. Ng, Marco Metra, Piotr Ponikowski, Sylwia M. Figarska
Journal: European Journal of Heart Failure (2022)
Substance Abuse
Authors: Sidney H. Schnoll
Journal: JAMA (1989)

In recent years there has been growing recognition of the problems that substance abuse is causing individuals and our society. These problems exist in many areas, such as health care, social function, and criminal justice. In the past, most federal support for drug abuse was targeted toward law enforcement to reduce the supply of drugs. Now, increasing funds are being appropriated for treatment, research, and prevention. Numerous approaches have been tried to reduce the supply of and demand for drugs. One effort to reduce the demand has been to increase the amount of random urine testing done by employers and government agencies. Although the data are not entirely clear whether this will be effective in reducing the drug problem, significant effort is being put into increasing the number of urine tests performed. Testing procedures can result in a high degree of accuracy, but it is difficult to maintain such accuracy