tbuckley/cabot-search huggingface dataset:
Abstract 2312: High Prevalence of Novel Amyloid Protein Deposition in Surgically Removed Heart Valves
Authors: Arnt V Kristen, Bettina Winter, Burkhard M Helmke, Philipp A Schnabel, Stefan Hardt, Achim Koch, Falk-Udo Sack, Hugo A Katus, Thomas J Dengler
Journal: Circulation (2008)

Amyloid deposition has been described in degenerative cardiac valve failure, but the prevalence, pathophysiology, and clinical indicators have not been clarified yet. Extensive histological analysis of 150 consecutive, surgically resected heart valve specimens (aortic n = 119, mitral n ± 31; 67.4 ± 1.0 years) was performed. Amyloid deposition was graded semi-quantitatively and classified by specific antisera identifying the most common amyloid proteins. Histological findings were correlated with clinical data. 119 patients had aortic valve disease: aortic stenosis (AS; 100/119; 84%), aortic regurgitation (19/119; 16%); 31 patients had mitral valve disease: mitral stenosis (7/31; 22.6%), mitral regurgitation (24/3177.4%). Amyloid was found in 83/150 (55.3%) specimens with the highest prevalence in aortic stenosis (74/100; 74%), intermediate in mitral stenosis (n = 2/7; 28.6%) and mitral regurgitation (n = 7/24; 29.2%), and lowest in aortic regurgitation (2/19; 10.5%). Moderate to severe amyloid deposition was almost exclusively found in aortic stenosis. Similarily coarse polymorphic amyloid deposits by morphologic analysis were most abundant in aortic stenosis (n = 35/100; 35%). Filamentous cloudy amyloid patterns occurred with the same frequency in aortic stenosis (n = 29/100; 29%). A combination of both was only found in aortic stenosis (n = 7/100; 7%). By immunohistochemical staining none of the most common amyloid proteins was identified. Some of the specimens were weakly stained by the apolipoprotein-AI antibody, more markedly adjacent to the amyloid fibrils. Amyloid deposition in aortic stenosis depended on hyperlipidemia, echocardiographic valvular thickening, and - by trend - on the presence of coronary artery disease, and obesity. Dystrophic valvular amyloidosis appears to represent an underestimated local manifestation of progressive destruction and scarring with diverse deposition pattern predominantly affecting stenotic aortic valves. It appears to depend on risk factors for atheroinflammatory processes and high shear-stress hemodynamic. The underlying protein structure has to be clarified in further studies.
Values and leadership
Authors: P. P Bapat
Journal: BMJ (2003)

Editor—My consultancy, the Values Partnership, will be working with some NHS organisations on leadership development and change. Pendleton and King articulate well the enormous benefits of aligning an organisation around a shared set of values.1-1 In our work with companies we have found that this alignment is the fundamental lever for driving change.

Without it, the only tools are manipulation, force, or domination, explaining the conflict that many organisations currently experience in trying to drive change. Three additional points are drawn from our experience.

Firstly, most NHS employees are personally aligned with the ultimate aims of the organisation, but this commitment seems to be manipulated by management. Basic factors such as trust and relationship are missing.

Secondly, the only way management and clinicians are going to find ways to deliver quality care for patients while adhering to budgetary constraints and hitting Whitehall targets is through alignment on higher level values and vision. Everyone is on the same side; problems become shared issues; and collaboration can happen. We have done this with clients many times, and it works.

Thirdly, the chief executive is critical in driving this process. Without a chief executive willing to participate in the conversation on values, to communicate the values, and to live them in his or her daily life, nothing will happen. We have seen many initiatives such as this one fail because management try to “do” values on the rest of the organisation without personally getting into the conversation seriously.

This values led approach to change is validated by the results of our clients and no doubt those of the authors, and proved by a lot of management research.1-2,1-3
Abstract 13246: Data Quality in the American Heart Association Get With the Guidelines-Stroke: Results from a National Data Validation Audit
Authors: Ying Xian, Gregg C Fonarow, Mathew J Reeves, Laura E Webb, Jason Blevins, Vladimir S Demyanenko, DaiWai M Olson, Adrian F Hernandez, Eric D Peterson, Lee H Schwamm, Eric E Smith
Journal: Circulation (2011)

Background: Get With The Guidelines-Stroke (GWTG-Stroke) is a national stroke registry and quality improvement program developed by the AHA. We examined the accuracy and reliability of data entered...
Neutrophil cathepsin G modulates the platelet surface expression of the glycoprotein (GP) Ib-IX complex by proteolysis of the von Willebrand factor binding site on GPIb alpha and by a cytoskeletal-mediated redistribution of the remainder of the complex
Authors: CA LaRosa, MJ Rohrer, SE Benoit, MR Barnard, AD Michelson
Journal: Blood (1994)
Handbuch der praktischen Therapie als Ergebnis experimenteller Forschung.
Authors: Paul Wolff, Reinhard von den Velden
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vulnerability to psychopathology in nicotine-dependent smokers: an epidemiologic study of young adults
Authors: N Breslau, M M Kilbey, P Andreski
Journal: American Journal of Psychiatry (1993)

In a previous article the authors reported associations between nicotine dependence and psychiatric disorders in a community sample of young adults. Increased lifetime rates of major depression and anxiety disorders were found in persons with DSM-III-R nicotine dependence but not in nondependent smokers. The purpose of the present study was to examine the associations of nicotine dependence with four measures of psychologic vulnerability to nonpsychotic psychiatric disorders.A randomly chosen group of 1,007 21- to 30-year-old members of a large health maintenance organization were interviewed with the National Institute of Mental Health Diagnostic Interview Schedule, revised for DSM-III-R diagnoses. Self-ratings of neuroticism, negative affect, hopelessness, and general emotional distress were obtained.Nicotine dependence, but not nondependent smoking, was associated with higher scores on all four measures of vulnerability to psychopathology. With one exception the associations between nicotine dependence and these psychologic measures remained significant when the variables current smoking status, history of major depression or anxiety disorders, alcohol and drug use disorders, race, and level of education were controlled; the association of nicotine dependence with general emotional distress was not significant.Neuroticism and the correlated psychologic vulnerabilities may commonly predispose to nicotine dependence and major depression or anxiety disorders.
Abstract 5545: An Experimental Study With Microwave Thermography for the Assessment of Atherosclerotic Vascular Disease
Authors: Konstantinos Toutouzas, Andreas Synetos, Maria Drakopoulou, Eleftherios Tsiamis, Antonis Karanasos, Archontoula Michelongona, Haris Grassos, Elli Stefanadi, Elias Siores, Christodoulos Stefanadis
Journal: Circulation (2009)

Background: Intravascular thermography (IVT) is the only method currently available, which can measure heat generation from atheromatic plaques indicating local inflammation. Thermal heterogeneity of the atheromatic plaque has been correlated with mophological characteristics of the culprit lesion in patients with coronary artery disease. Microwave radiometry (MR) is a new non-invasive method. We investigated whether thermal heterogeneity measured by MR is correlated with IVT findings in an experimental model of atherosclerotic disease. Methods: Microwave radiometry (RTM-01-RES system) was applied noninvasively in 18 atherosclerotic segments of the aorta (3 segments, 5cm long in 6 rabbits) that were clearly separated from each other, as well as in 18 control segments. Microwave radiometry measures natural electromagnetic radiation from the internal tissues at microwave frequencies that is proportional to the temperature of tissue. The system consists of an internal temperature sensor with the antenna, a skin temperature sensor and the data processing unit. The accuracy of measuring the internal temperature of the device is±0.2°C and the depth of temperature detection is 1–7 cm. Thereafter, IVT was performed in the same segments. For both techniques temperature difference (ΔT) was calculated by subtracting the mean temperature of proximal healthy vessel wall from the maximal temperature of each segment. Results: Thermal heterogeneity was detected by both methods in the rabbits with the high atherogenic diet. Microwave radiometry detected that ΔT of the atherosclerotic aortas was significantly higher compared to the ΔT of the controls (0.98±0.27 °C versus 0.40±0.14°C, p&lt;0.001). These findings were confirmed by the measurements acquired by IVT. Mean temperature difference was 0.07±0.01 °C for the atherosclerotic aortas versus 0.02±0.01°C, (p&lt;0.001) for the control group. The segments that had the highest ΔT were those that were recognized in angiography as having significant atheromatosis. Conclusion: Microwave radiometry is the first non-invasive method for detection of local inflammatory activation in arterial segments in an experimental model. Further studies in humans should be performed for the evaluation of this method.
Abstract 2539: Cardiac {beta}-adrenergic Remodeling in the Early Phase of Endotoxemic Shock
Authors: Leslie Audigane, Bertrand Rozec, Emmanuelle Lavazais-Blancou, Nolwenn Merlet, Morteza Erfanian, Hatsumi Yoshiki, Ikunobu Muramatsu, Chantal Gauthier
Journal: Circulation (2009)
Abstract 4378: More Than 10 Years Clinical Follow-up After Endovascular Therapy in Patients With Intermittent Claudication
Authors: Yoshimitsu Soga, Hiroyoshi Yokoi, Kenji Ando, Shinichi Shirai, Koyu Sakai, Masashi Iwabuchi, Masakiyo Nobuyoshi
Journal: Circulation (2009)

Background: A little is known about long-term outcomes of patients with intermittent claudication (IC) undergoing endovascular therapy (EVT). In this study, we sought to investigate its impact on s...
Workgroup Report: Public Health Strategies for Reducing Aflatoxin Exposure in Developing Countries
Authors: Heather Strosnider, Eduardo Azziz-Baumgartner, Marianne Banziger, Ramesh V. Bhat, Robert Breiman, Marie-Noel Brune, Kevin DeCock, Abby Dilley, John Groopman, Kerstin Hell, Sara H. Henry, Daniel Jeffers, Curtis Jolly, Pauline Jolly, Gilbert N. Kibata, Lauren Lewis, Xiumei Liu, George Luber, Leslie McCoy, Patience Mensah, Marina Miraglia, Ambrose Misore, Henry Njapau, Choon-Nam Ong, Mary T.K. Onsongo, Samuel W. Page, Douglas Park, Manish Patel, Timothy Phillips, Maya Pineiro, Jenny Pronczuk, Helen Schurz Rogers, Carol Rubin, Myrna Sabino, Arthur Schaafsma, Gordon Shephard, Joerg Stroka, Christopher Wild, Jonathan T. Williams, David Wilson
Journal: Environmental Health Perspectives (2006)

Consecutive outbreaks of acute aflatoxicosis in Kenya in 2004 and 2005 caused &gt; 150 deaths. In response, the Centers for Disease Control and Prevention and the World Health Organization convened a workgroup of international experts and health officials in Geneva, Switzerland, in July 2005. After discussions concerning what is known about aflatoxins, the workgroup identified gaps in current knowledge about acute and chronic human health effects of aflatoxins, surveillance and food monitoring, analytic methods, and the efficacy of intervention strategies. The workgroup also identified public health strategies that could be integrated with current agricultural approaches to resolve gaps in current knowledge and ultimately reduce morbidity and mortality associated with the consumption of aflatoxin-contaminated food in the developing world. Four issues that warrant immediate attention were identified: a) quantify the human health impacts and the burden of disease due to aflatoxin exposure; b) compile an inventory, evaluate the efficacy, and disseminate results of ongoing intervention strategies; c) develop and augment the disease surveillance, food monitoring, laboratory, and public health response capacity of affected regions; and d) develop a response protocol that can be used in the event of an outbreak of acute aflatoxicosis. This report expands on the workgroup’s discussions concerning aflatoxin in developing countries and summarizes the findings.
Abstract 1581: Patient Compliance With Single Pill, Dual and Triple Antihypertensive Combinations
Authors: Feride H Frech-Tamas, Winnie Zhang, Homa B Dastani, Douglas Gause
Journal: Circulation (2009)

Patient adherence is essential to achieve blood pressure control and favorable patient outcomes. Our objective was to compare the compliance of patients taking a single pill combination (SPC) of valsartan+amlodipine versus dual and triple therapy with an angiotensin receptor blocker (ARB) + a dihydropyridine calcium channel blocker (CCB) with or without hydrochlorothiazide (HCTZ). A retrospective cohort study of pharmacy and medical claims (Medstat MarketScan ® ) was conducted. Patients included in the study were continuously insured from January 2007 to September 2008, were ≥18 years of age with a hypertension medical claim and with 2 or more fills for valsartan+amlodipine (“SPC”), an ARB+CCB free combination (“dual”) or an ARB+CCB+HCTZ free combination (“triple”) concomitantly between July 2007 and September 2008. “Concomitant” was defined as prescriptions filled within 30 days of each other. All patients were initiating therapy, meaning they had no prescriptions for these agents 6 months prior to the first fill. Compliance was measured using the medication possession ratio (MPR), defined as the percent of days’ supply between the initial and last fill dates. Descriptive statistics and 95% Bootstrap confidence intervals were calculated using SAS software. The study population consisted of 29,627 individuals (11,588 SPC, 17,868 dual, 171 triple) with mean age 61.7 years and 49% female. The top three prevalent comorbid conditions were ischemic heart disease (18.2%), cerebrovascular disease (11.3%) and diabetes (4.0%). Mean compliance (95% CI) was 0.85 (0.84, 0.85), 0.63 (0.63, 0.64), and 0.54 (0.51, 0.58) for SPC, dual and triple, respectively. Patients taking single pill combinations were significantly more compliant than patients taking dual and triple antihypertensive therapy. The findings support existing evidence suggesting a negative impact of pill burden on compliance and the value of single pill combinations.
The Temptation of the Magdalene
Authors: M. Therese Southgate
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myocardial Contrast Echocardiography Evolving as a Clinically Feasible Technique for Accurate, Rapid, and Safe Assessment of Myocardial Perfusion
Authors: Pieter A. Dijkmans, Roxy Senior, Harald Becher, Thomas R. Porter, Kevin Wei, Cees A. Visser, Otto Kamp
Journal: Journal of the American College of Cardiology (2006)
Abstract 3127: The Impact of Glycemic Control on the Risk of Macrovascular Complications among Primary Care Patients with Type 2 Diabetes
Authors: Edward Ewen, Rani Singh, Xiaozhang Jiang, William S Weintraub
Journal: Circulation (2008)

Background: The role of aggressive diabetic management in the prevention of macrovascular complications remains unclear. This study of longitudinal electronic medical records (EMR) examines the ris...
Abstract 11209: The Onset of Heart Failure is Associated With The Extent of LV Fibrosis in Hypertrophic Cardiomyopathy: Insights From Cardiac Magnetic Resonance Analysis
Authors: Takashi Nakamura, Yoshitaka Iwanaga, Masakazu Yasuda, Tomoyuki Ikeda, Hanako Morooka, Shunichi Miyazaki
Journal: Circulation (2013)

Background: The patients with hypertrophic cardiomyopathy (HCM) are frequently complicated with heart failure (HF), which is associated with the patient’ prognosis. However, the onsets are diverse ...
Abstract 3529: Early Detection of Transplant Rejection by in vivo 19F MRI
Authors: Ulrich Flogel, Song Su, Inga Kreideweiss, Zhaoping Ding, Andre Horning, Oliver Witzke, Jurgen Schrader
Journal: Circulation (2009)

Introduction: Diagnosis of transplant rejection requires endomyocardial biopsy and entails risks. Here, we describe a new 19F MRI approach for detection of organ rejection making use of emulsified ...
TAVI in Patients Unsuitable for Surgery
Authors: Olaf Wendler, Rafal Dworakowski
Journal: Journal of the American College of Cardiology (2013)

Since Alain Cribier performed the first human transcatheter aortic valve implantation (TAVI) in 2002 [(1)][1], the procedure has evolved into a reproducible and safe technique with >100,000 procedures performed worldwide. Early experience with new devices and techniques in Europe led to advanced
Addressing Human Variability in Next-Generation Human Health Risk Assessments of Environmental Chemicals
Authors: Lauren Zeise, Frederic Y. Bois, Weihsueh A. Chiu, Dale Hattis, Ivan Rusyn, Kathryn Z. Guyton
Journal: Environmental Health Perspectives (2012)

Characterizing variability in the extent and nature of responses to environmental exposures is a critical aspect of human health risk assessment.Our goal was to explore how next-generation human health risk assessments may better characterize variability in the context of the conceptual framework for the source-to-outcome continuum.This review was informed by a National Research Council workshop titled "Biological Factors that Underlie Individual Susceptibility to Environmental Stressors and Their Implications for Decision-Making." We considered current experimental and in silico approaches, and emerging data streams (such as genetically defined human cells lines, genetically diverse rodent models, human omic profiling, and genome-wide association studies) that are providing new types of information and models relevant for assessing interindividual variability for application to human health risk assessments of environmental chemicals.One challenge for characterizing variability is the wide range of sources of inherent biological variability (e.g., genetic and epigenetic variants) among individuals. A second challenge is that each particular pair of health outcomes and chemical exposures involves combinations of these sources, which may be further compounded by extrinsic factors (e.g., diet, psychosocial stressors, other exogenous chemical exposures). A third challenge is that different decision contexts present distinct needs regarding the identification-and extent of characterization-of interindividual variability in the human population.Despite these inherent challenges, opportunities exist to incorporate evidence from emerging data streams for addressing interindividual variability in a range of decision-making contexts.
Advertising by pharmaceutical companies in eBMJ
Authors: S. McKechnie, R. Smith
Journal: BMJ (1999)

Editor—It is regrettable that the BMJ has taken the decision to accept advertising from the pharmaceutical industry on its website. This will serve only to under- mine the spirit and intended practice of the Medicines Act and the industry code of practice that explicitly prohibits the advertising of prescription drugs to the public.

Whereas the Medicines Control Agency might think that advertising by pharmaceutical companies on the BMJ’s website is acceptable because the intended audience is doctors and not the public, in reality far more patients will visit the online journal than read the subscription only paper version.

In the United States the impact on health of the billion dollar business of advertising prescription drugs to consumers has raised serious concerns. The implications of advertising prescription drugs to consumers must be considered, particularly in the light of rational prescribing and clinical excellence.

I urge you to reconsider your decision and to ensure that we do not slide into a situation in which the pharmaceutical industry has direct and unmanaged links with consumers before there has been a proper debate on the issue.