tbuckley/cabot-search huggingface dataset:
Unilateral proptosis with thyrotoxicosis resulting from solitary retroorbital soft tissue metastasis from follicular carcinoma thyroid.
Authors: SANDIP BASU, NARENDRA NAIR, NOTTOTH ARAVIND
Journal: Clinical Nuclear Medicine (2001)

Unilateral proptosis can be of neoplastic origin, even if the results of thyroid function tests suggest hyperthyroid disease, and it needs proper investigation with a computed tomographic scan of the orbit. The authors present a case of left-sided proptosis resulting from a metastasis in the retroorbital soft tissue from follicular carcinoma of the thyroid. A nodular goiter involving the left lobe and isthmus was found. The initial thyroid function test values suggested hyperthyroid disease and the patient had clinical signs of toxicity. A computed tomographic scan of the orbit revealed a left-sided retroorbital soft tissue mass, part of which was resected and found be to a metastasis from follicular carcinoma of thyroid. Total thyroidectomy was performed and the patient was treated with I-131 after operation. The proptosis resolved with I-131 treatment.
Abstract 2607: TGF-beta 1 as a Diagnostic Biomarker for Acute Aortic Dissection Type A in a Mouse Model of Marfan Syndrome
Authors: Peter Matt, Jennifer Habashi, Florian Schoenhoff, James Black, Martin Grapow, Friedrich Eckstein, Thierry Carrel, David Huso, Jennifer E Van Eyk, Harry C Dietz
Journal: Circulation (2008)

Objectives: Acute aortic dissection type A is the main cause of mortality in patients with Marfan Syndrome (MFS). The aim of this study was to develop a procedure to surgically induce an acute aortic dissection type A in a mouse model of MFS, and to discover a diagnostic biomarker of the aortic lesion. Methods: Ten fibrillin-1 deficient (Fbn1C1039G/+) and ten wild-type (WT) mice at 8 months of age were intubated, ventilated and the aorta exposed via hemisternotomy. We hypothesized that an aortic dissection type A could be induced by performing an aortic clamp injury. Serum samples were collected before and after induction (30 min) of the aortic lesion from the right femoral vein. Total (acid activated) TGF-beta 1 concentrations were measured by ELISA. Echo measurements of the aortic root were obtained from a parasternal long axis view in all mice. Results: Transthoracic echocardiography of the aortic root performed prior to surgery showed significantly larger diameters in Fbn1C1039G/+ mice compared to WT (p&lt;0.0001). Aortic clamp injury led in Fbn1C1039G/+ and WT mice to a reproducible aortic wall hematoma, and intimal tears. Hematoxylin-eosin stained histological sections revealed aortic dissection of the medial layer in Fbn1C1039G/+ mice but not in WT (p&lt;0.001). Elastin-stained sections revealed a significantly higher elastic fiber fragmentation and disarray in Fbn1C1039G/+ aortas compared to WT (p&lt;0.001). Aortic dissection in Fbn1C1039G/+ mice was limited to the ascending aorta. Mean TGF-beta 1 serum concentrations significantly increased after inducing the aortic lesion in Fbn1C1039G/+ mice (p=0.01; 130 ng/ml vs 412.9 ng/ml) but not in WT mice (p=0.2). Sham operated Fbn1C1039G/+ and WT mice showed no difference in TGF-beta 1 serum concentrations before and after surgery (p=0.7; n=4). Conclusions: We present a reproducible and in the short-term non-lethal mouse model of a surgically induced acute aortic dissection type A in MFS. TGF-beta 1 serum concentrations after inducing the aortic lesion significantly increased in Fbn1C1039G/+ mice but not in WT and Sham operated mice. TGF-beta 1 is a promising diagnostic biomarker for an acute aortic dissection type A in MFS.
Staring into the abyss: walking the nuclear tightrope in south Asia
Authors: Z. A. Bhutta
Journal: BMJ (1998)

Pokaran and Chagai, two remote wastelands in India and Pakistan, convulsed painfully under the impact of 11 nuclear explosions in May this year, as both countries overtly crossed the nuclear threshold. In the weeks that followed the widespread euphoria and irresponsible jingoism witnessed in the streets of Delhi and Islamabad has given way to introspection and the beginnings of a real debate on the implications of a nuclear arms race in the subcontinent.

Although the genie of nuclear capability in both countries has been well and truly let out, it is imperative that India and Pakistan refrain from embarking on a nuclear weapons build up. It may already be too late to prevent such a build up, but there are several compelling reasons why such a programme in the subcontinent may not serve as a real deterrent to war but greatly enhance its risks and costs.

The analogy with the nuclear stalemate between the United States and the Soviet Union is misguided, as neither India nor Pakistan possesses the technology or resources for the requisite safeguards and early warning systems that the United States and Soviet Union eventually established. …
Shifts in oxidation states of cerium oxide nanoparticles detected inside intact hydrated cells and organelles
Authors: Craig J. Szymanski, Prabhakaran Munusamy, Cosmin Mihai, Yumei Xie, Dehong Hu, Mary K. Gilles, Tolek Tyliszczak, Suntharampillai Thevuthasan, Donald R. Baer, Galya Orr
Journal: Biomaterials (2015)
Impact of number of lymph nodes (LN) examined at the time of surgical resection (Sx) on the survival of stage IA non-small cell lung cancer (NSCLC) patients (pts)
Authors: A. M. Ingle, P. Kumar, M. M. Griggs, C. A. Erangey, S. P. Thomas
Journal: Journal of Clinical Oncology (2008)

7534 Background: Despite complete Sx pts with stage IA have an approx. 5yr survival of only 61%. Better prognostic factors need to be identified in this stage. In this study we evaluated the effect of detailed surgical LN exam on Progression Free Survival (PFS) and Overall Survival (OS) of these pts. Methods: All pts with pT1pN0M0 (stage IA) NSCLC from 11/2000 to 12/2006 at OSF Saint Francis Medical Center, Peoria, IL were deemed eligible. Log rank and Cox proportional hazard model (CPHM) was used to estimate survival rates and relative risks. For the purpose of analyses, number of LN examined was broken down in 4 groups; 1–3 (group1or G1), 4–6 (G2), 7–9 (G3), > 9 lymph nodes (G4). Results: Of the 112 eligible pts, analyses were performed on 98 pts with complete data on pathologic tumor stage, number of LN, grade, differentiation and race. Demographics are as follows: median age: 71 (33–83 yrs), median follow-up time: 2.08 years (0.07–5.31 yrs). LN groups pts numbers: G1: 33 (33.7%) pts, G2; 33 (33.7%) pts, G3: 19 (19.3%) and G4: 13 (13.3%). We observed a statistically significant increasing trend in PFS with increase in number of LN examined (Log Rank p-value=0.039). No significant trend in OS was observed with increase in number of LN (log-rank p-value=0.2). 4 yr PFS for G1, G2, G3, G4 was18.1%, 67.9%, 52.6%, 72.7%. 4 yr OS for G1, G2, G3, G4 was 38.3%, 73.8%, 52.6%, 87.5%. CPHM demonstrated an increase in survival of G2, G3 and G4 as compared to G1 (PF Hazard ratios: 0.37, 0.53, 0.26; Overall Hazard Ratios: 0.44, 0.74 and 0.33 respectively). Conclusions: This data suggests that there is a significant increase in PFS survival with increase in number of LN examined at surgery in stage IA NSCLC pts. No significant financial relationships to disclose.
Diffuse Myocardial Fibrosis and Inflammation in Rheumatoid Arthritis
Authors: Ntobeko A.B. Ntusi, Stefan K. Piechnik, Jane M. Francis, Vanessa M. Ferreira, Paul M. Matthews, Matthew D. Robson, Paul B. Wordsworth, Stefan Neubauer, Theodoros D. Karamitsos
Journal: JACC. Cardiovascular imaging (2015)
Clinical Pathology of the Jaws with a Histologic and Roentgen Study of Practical Cases
Authors: Kurt Hermann Thoma
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 9963: The A2B Adenosine Receptor Antagonist (GS-6201) Improves Cardiac Remodeling and Dysfunction after Myocardial Infarction (MI) in Rat
Authors: Haiyun Ling, Liguo Chi, Hongyan Zhong, Aliya Zeng, Jason Oliver, John Liles, Dewan Zeng, Luiz Belardinelli, Arvinder Dhalla
Journal: Circulation (2012)

Activation of A 2B adenosine receptors in cardiac cells stimulates the release of inflammatory cytokines and fibrotic mediators. Adenosine concentration is elevated and A 2B receptor expression is increased in hypoxic /ischemic myocardium. In the present study, the effect of GS-6201 (GS), a selective and potent A 2B adenosine receptor antagonist (Ki 8.3 nM), alone or in combination with enalapril (ENL), was evaluated in a rat model of MI-induced cardiac remodeling and dysfunction (25-min myocardial ischemia followed by 5-wk reperfusion). Starting one week after MI, animals (n=8-13/group) were treated with GS (30 mg/kg), ENL (6 mg/kg), GS+ ENL or placebo via oral gavage once daily for 4 weeks. Serial echocardiographic assessments of LV geometry and function were conducted at baseline, 1, 3 and 5 weeks after MI. Significant cardiac dysfunction, hypertrophy and fibrosis developed in placebo treated animals. Compared to the placebo, GS, ENL and GS+ENL significantly improved LV ejection fraction (EF) and fractional shortening (FS), reduced LV end-systolic volume and decreased myocardial fibrosis at 5 week post MI. GS, ENL and GS+ ENL also significantly ameliorated plasma biomarkers including IL-6, TGF-β1 and BNP. Data were shown in Table 1. In summary, A 2B adenosine receptor antagonist GS-6201 effectively reduced MI-induced LV remodeling and dysfunction in a rat model, possibly mediated through anti-inflammatory and anti-fibrotic mechanisms. The effects of GS-6201 and ENL were comparable, while the combination of GS-6201 with ENL provided an additional benefit.
Comparison Of Allogeneic Hematopoietic Cell Transplantation Versus Chemotherapy In Patients With Acute Myeloid Leukemia In First Remission
Authors: Xiaoyu Lai, Mingyu Zhu, Yi Luo, Yamin Tan, Weiyan Zheng, Yuanyuan Zhu, Jimin Shi, He Huang
Journal: Blood (2013)
Problems in Geriatric Medicine.
Authors: Anthony Martin
Journal: Annals of Internal Medicine (1983)

1 Demographic and social factors.- 2 Disorders of the cardiovascular system (I) Myocardial and valvular disease blood pressure.- 3 Disorders of the cardiovascular system (II) Disorders of cardiac rhythm and conduction pacemakers.- 4 Disorders of the cardiovascular system (III) Diseases of the arteries.- 5 Strokes.- 6 Fits, faints and falls.- 7 Failing mobility ('gone off his feet syndrome').- 8 Incontinence.- 9 Memory, confusion and sleep.- 10 The use and misuse of drug treatment.- 11 Bone disease and fractures.- 12 Disorders of the blood.- 13 Endocrine diseases.
Abstract 21162: Subcostal Exchange of Left Ventricular Assist Devices - A Novel Approach
Authors: George J Arnaoutakis, Jeremiah G Allen, Pramod Bonde, Stuart D Russell, Ashish S Shah, John V Conte
Journal: Circulation (2010)

Introduction: A limitation of long-term left ventricular assist device(LVAD) support is the need for device exchange, with risks of a redo-sternotomy. We describe LVAD exchange through a novel, les...
Abstract 237: Do We Treat Women Differently? Health Care Providers’ Perspectives on Gender Differences in Post-arrest Care
Authors: Janet Parsons, Valeria E Rac, Natalie A Baker, Elizabeth Racz, Michelle Gaudio, Paul Dorian, Robert Fowler, Arthur Slutsky, Katie Dainty, Damon Scales, Arlene S Bierman, Beth L Abramson, Sheldon Cheskes, Sara Gray, Alex Kiss, Laurie J Morrison
Journal: Circulation (2013)

Objective: To explore the perspectives of health care providers (HCP) on previously observed gender-related differences in post-arrest care, and to identify potential barriers to care delivery amenable to modification that may minimize disparities in care. Methods: Qualitative study based on semi-structured interviews conducted with 27 HCPs at six hospitals in southern Ontario from July 2012 through March of 2013. A combination of purposeful and snowball sampling was used to recruit representative participants: gender, age, professional designation, and practice settings). Interviews were conducted by phone or in-person and lasted from 15-60 minutes. All interviews were audio-taped, transcribed, and coded inductively using a descriptive content analytic approach to identify common themes and patterns (constant comparison). Results: Most HCPs indicated that they did not feel that the care offered to female and male post-arrest patients was markedly different; rather each patient is treated as “a life to be saved” where treatment is by protocol and each arrest is context-dependent. In attempting to address potential differences in care, participants characterized gender as one of many contributing factors (clinical, social and individual circumstances), that are entangled with other social determinants of health (age, family structure, ethnicity). Factors operating at the individual-, institutional- and social structural levels may explain any observed differences. For example, once patients are transferred to the ICU for ongoing management, many HCPs felt that decision-making surrounding withdrawal of life support might differ based on gender, but intersects closely with other factors including family support, ethnicity and religion. Conclusion: HCPs do not perceive gender-based differential access to evidence-based resuscitation care is occurring. They do not believe differential access is contributing to observed differences in post-arrest outcomes between men and women. Rather, gender was portrayed as embedded within an array of social determinants of health as well as clinical and physiological factors that were difficult to separate. Future studies should focus on these other factors and explore how they relate to gender.
Medicine on the Lewis and Clark Trail
Authors: Brian Vastag
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3347: Sirolimus Eluting Stents In Single Vessel Versus Multi-vessel Percutaneous Coronary Intervention: Results From The Matrix Registry
Authors: Satya R Atmakuri, Roxana Mehran, Kotaro Obunai, Anuj Gupta, George Syros, Edward M Kreps, Michael B Collins, William A Gray, Jeffrey W Moses, Martin B Leon, Gregg W Stone, George D Dangas
Journal: Circulation (2007)

Background The efficacy of sirolimus eluting stents (SES) to reduce in-stent restenosis compared to bare metal stents has been studied in single coronary vessels. However, the long-term efficacy and safety of SES implantation in multiple coronary vessels has not been well studied. We compared the efficacy and safety of SES implanted in single vessel versus multi-vessel PCI. Methods The MATRIX registry prospectively evaluates the efficacy and safety of SES in a “real world” population. In this registry, SES was implanted in single vessel PCI in 1103 patients and in multi-vessel PCI in 321 patients. Dual anti-platelet therapy with aspirin and clopidogrel was recommended for at least one year. All clinical events are source-documented and adjudicated by an independent committee. Results The multi-vessel PCI group had more patients with diabetes (38.4% vs. 32.4%, p=0.04), but less patients with prior PCI (37.7% vs. 46.6%, p=0.006) and prior CABG (17% vs. 22.3%, p=0.04). The mean number of stents implanted was 1.7 ± 0.9 vs. 3.1 ± 1.1 with procedural success of 96.7% vs. 95.6% in single and multi-vessel PCI groups respectively. The two-year clinical outcomes are shown in the table . Conclusions We documented no significant differences in single vs. multi-vessel PCI with sirolimus DES. Therefore, with appropriate patient selection and PCI technique, the treatment with multi-vessel PCI appears to be as safe and effective as single vessel PCI.
Antithrombin Plasma Levels and Fibtem Determination in Children with Acute Lymphoblastic Leukemia Undergoing Asparaginase Treatment
Authors: Giada Biddeci, Giovanna Sanna, Giulia Geranio, Stefania Varotto, Elena Varotto, Maria Gabelli, Mariagrazia Petris, Sara Maggiolo, Elena Campello, Maria Bon, Paolo Simioni, Luca Spiezia, Sartori Maria Teresa, Giuseppe Basso, Maria Caterina Putti
Journal: Blood (2014)
Abstract 16484: Maintaining Cardiac Fatty Acid Oxidation in Pressure-Overload Hypertrophy Preserves Function and Energetics
Authors: Stephen C Kolwicz, David P Olson, Luke Marney, Lorena Garcia-Menendez, Soeun Ngoy, Robert E Synovec, Ronglih Liao, Rong Tian
Journal: Circulation (2011)

The reversion to the fetal metabolic profile in the hypertrophied heart is well documented, although whether this shift is adaptive or maladaptive is still questioned. Since malonyl CoA production ...
Safety, tolerability, and pharmacokinetics of TAK-701, a humanized anti-hepatocyte growth factor (HGF) monoclonal antibody, in patients with advanced nonhematologic malignancies: First-in-human phase I dose-escalation study.
Authors: S. F. Jones, R. B. Cohen, J. C. Bendell, C. S. Denlinger, R. D. Harvey, S. Parasuraman, X. Chi, C. Scholz, T. Wyant, J. Kauh
Journal: Journal of Clinical Oncology (2010)

3081 Background: TAK-701 binds to HGF and inhibits HGF/C-MET-mediated human tumor proliferation in preclinical studies. Methods: Patients aged ≥18 y with advanced nonhematologic malignancies for which standard curative or life-prolonging treatment was not available or no longer effective received up to twelve 28-d cycles of TAK-701 at 5 dose levels: 2, 5, 10, 20 and 30 mg/kg. In cycle 1, pts received a single IV infusion of TAK-701 at twice the assigned dose level on day 1; in subsequent cycles pts received TAK-701 at the assigned dose level on days 1 and 15 of 28-d cycles. Dose escalation was based on dose-limiting toxicities (DLTs) during cycle 1. Primary objectives were to assess safety and serum pharmacokinetics (PK), and determine the maximum tolerated dose (MTD). Secondary objectives included blood pharmacodynamics (PD) and response assessments. Results: At data cut-off (Dec 8, 2009), 20 pts had been enrolled to the first 4 dose levels: 3, 3, 3 and 11 to the 2, 5, 10 and 20 mg/kg cohorts, respectively. Pts received a median of 2 cycles (range 1–6). 4 of 8 evaluable pts achieved investigator-assessed stable disease. The most common adverse events (AEs) were cough (4 pts), abdominal pain, constipation and fatigue (3 pts each), all grade 1/2. There were 3 grade 3 AEs (gastrointestinal ileus, pleural effusion, urinary tract infection) and 1 grade 4 AE (dyspnea). There were 4 deaths, all due to progressive disease. There were no DLTs; the MTD has not been reached. No pt discontinued due to AEs. Preliminary PK/PD analyses for the 2, 5 and 10 mg/kg cohorts indicate dose-proportional PK (Cmax and AUC(0–28 d)). Mean (SD) half-life estimates based on day 1 dosing were 9.56 (2.93), 8.64 (4.19) and 14.1 (4.76) days, respectively. All pts showed increases in total serum HGF following TAK-701 administration; no free serum HGF was detected throughout the dosing interval. Human antihuman antibody analyses are ongoing. Conclusions: TAK-701 up to 20 mg/kg bi-weekly was well tolerated; enrolment to the 30 mg/kg dose level is ongoing. Updated safety, PK/PD, and preliminary response data for all phase I pts will be presented. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Millennium Millennium Millennium Millennium
Abstract 13931: Effects of PGE2 on Renal CD44+ Mesenchymal Stem Cell (CD44+ MSC) Migration
Authors: Yanqiang Yang, Hao Wang, Jose Gomez, Zhiping Zhang, Richard Pratt, Maria Mirotsou, Victor J Dzau
Journal: Circulation (2011)

Background: Recent studies have identified a reservoir of stem and progenitor cells in the adult kidney. However, the significance of these observations for renal function remains unclear. Our labo...
Differences in hepatitis B infection rate between ethnic groups in antenatal women in Birmingham, United Kingdom, May 2004 to December 2008
Authors: M Caley, T Fowler, S Greatrex, A Wood
Journal: Eurosurveillance (2012)

Hepatitis B virus (HBV) is a major cause of morbidity and mortality worldwide. Although the United Kingdom (UK) prevalence of HBV is low, it is increasing. There is some evidence that the rate of infection is much higher in some populations living in Britain of non-white ethnicity or who were not born in Britain, compared with the British-born white population. We examined the prevalence of HBV infection in pregnant women through hepatitis B surface antigen (HBsAg) or e-antigen (HBeAg) in Birmingham UK between May 2004 and December 2008 and the effect of ethnicity on the relative risk of infection. There was a significant increase in the number of antenatal HBV infections detected over the study period from 106 cases in 2005 to 161 cases in 2008 (p=0.037). Women who define themselves as of black African, non-British white and Pakistani ethnicity had a markedly elevated rate of HBV infection (relative risk (RR): 11.25, 5.87 and 2.33 respectively) compared to the England average. Health organisations that serve populations with a high or increasing proportion of women originating from intermediate and high HBV prevalence areas of the world such as Africa, some parts of Europe and Asia, should anticipate a need for perinatal and postnatal prophylaxis to children born to HBV infected mothers.
Any academy should stay away from realpolitik
Authors: T. Keable-Elliott
Journal: BMJ (1994)

EDITOR,—When Tony Grabham confines himself to ethical issues (incidentally, I believe that performance related pay in medicine is primarily an ethical issue) I broadly agree with his view that the profession needs to present a united front.1 The BMA's ethical committee has worked wonders over the past few years, but the BMA's council does not provide the ideal forum in which to debate the broad issues: time …