tbuckley/cabot-search huggingface dataset:
Shared Decision-making in Dermatology
Authors: Tessalyn Morrison, Jacob Johnson, Wenelia Baghoomian, Andrew Hamilton, Eric Simpson, Teri Greiling, Erin Foster
Journal: JAMA Dermatology (2021)

<h3>Importance</h3> Shared decision-making (SDM) can improve the quality of care for patients. The extent to which this tool has been used and the evidence supporting its use in dermatology have not been systematically examined. <h3>Objective</h3> To perform a scoping review of the literature regarding SDM in dermatology. <h3>Evidence Review</h3> Searches of Ovid MEDLINE, PsycINFO, PsycARTICLES, Sciverse Scopus, and EBM Reviews were conduced on July 11, 2019, and March 6, 2020. There were no limits on date, type of article, language, or subject for the initial search. A total of 1673 titles and abstracts were screened by 2 independent reviewers in the Covidence mixed-methods platform. Forty-one full-text studies were assessed for eligibility. For inclusion, articles needed to include a dermatologic diagnosis as well as discussion of SDM or patient decision aids. Two independent reviewers screened 29 full-text articles for inclusion and extracted qualitative data using a set of 26 predefined codes. Qualitative coding was applied to excerpts to categorize the article, define and describe advantages and disadvantages of SDM, understand patient and physician requests for SDM, and discuss methods of implementation. <h3>Findings</h3> Despite a small number of articles on SDM (n = 29) in dermatology, the selected literature provided consistent messages regarding the importance of SDM for dermatology and a number of strategies and tools for implementation. Medical dermatology was the most common subspecialty studied, with melanoma, psoriasis, and connective tissue diseases most examined. Only 5 publications introduced SDM tools specifically for dermatologic conditions; of these, only 2 tools were validated. Barriers to implementation that were cited included time and a lack of training for clinicians, although the literature also provided potential solutions to these issues. All articles emphasized the value of SDM for both patients and physicians. <h3>Conclusions and Relevance</h3> The literature regarding SDM in dermatology consistently suggests that it is a useful tool for providing patient-centered care. Established tools have been proposed since 2012. More research is needed to implement better practices, especially in dermatologic subspecialties. However, there are substantial suggestions from the literature for strategies and tools with which to begin a shared decision-making practice.
Absolute Coronary Blood Flow Measured by Continuous Thermodilution in Patients With Ischemia and Nonobstructive Disease
Authors: Regina E. Konst, Suzette E. Elias-Smale, Dario Pellegrini, Mariëlle Hartzema-Meijer, Bas J.C. van Uden, Tijn P.J. Jansen, Priya Vart, Helmut Gehlmann, Angela H.E.M. Maas, Niels van Royen, Peter Damman
Journal: Journal of the American College of Cardiology (2021)
Correspondence on ‘Non-surgical and surgical treatments for rotator cuff disease: a pragmatic randomised clinical trial with 2-year follow-up after initial rehabilitation’
Authors: Pietro Randelli, Lavinia Agra Coletto, Alessandra Menon, Roberto Caporali
Journal: Annals of the Rheumatic Diseases (2021)

With great interest, we read the relevant results of a randomised clinical trial designed to compare conservative and surgical approach for treating rotator cuff disease (RCD), leading cause of shoulder pain and disability in adult’s population. The study highlighted the superiority of surgery, by means of shoulder pain (Visual Analogue Scale) and function (Constant Murley Score) improvement after 2 years, in patients with full-thickness rotator cuff tear.1 Whereas, as already stated in other studies,2 3 RCD without full-thickness tendon tear benefits equally from either non-surgical treatment or subacromial decompression.

Based on the experience of our hospital, where orthopaedics and rheumatologists work everyday side by side, we would like to make some comments and to share our point of view.

The power of the study lies in the fact that potential eligible patients underwent a systematic adequately performed 3-month rehabilitation, after which only who was still symptomatic was randomised.

The trial was designed in order to distinguish, right from the …
Agreement Between 18F-FDG PET/CT and Whole-Body Magnetic Resonance Compared With Skeletal Survey for Initial Staging and Response at End-of-Treatment Evaluation of Patients With Multiple Myeloma
Authors: Nieves Gómez León, Beatriz Aguado Bueno, María Herreros Pérez, Luisa F. León Ramírez, Adrián Alegre, Patrick M. Colletti, Domenico Rubello, José L. Carreras, Roberto C. Delgado Bolton
Journal: Clinical Nuclear Medicine (2021)

Purpose To compare the agreement between whole-body (WB) magnetic resonance (MR) imaging, 18 F-FDG PET/CT, and skeletal survey (SS) in patients with multiple myeloma (MM) for diagnosis, initial staging, response evaluation, and early detection of complications. Methods This is a retrospective cohort study including MM patients who were diagnosed, treated, and followed in 2 institutions. These patients were studied with SS, WB-MR, and/or 18 F-FDG PET/CT. We studied bone lesions by anatomical locations and analyzed the concordance between SS and a tomographic technique (WB-MR or 18 F-FDG PET/CT) and between both tomographic techniques (WB-MR and PET/CT). Results Forty-four MM patients with a mean age of 62.6 years (range, 38–85 years) were included from January 2012 to February 2016. Whole-body MR and 18 F-FDG PET/CT found more lesions than SS in every location except in the skull. Concordance between WB-MR and 18 F-FDG PET/CT was either good or excellent in most of the locations and in plasmacytoma studies. However, WB-MR was better than 18 F-FDG PET/CT in the study of complications (medullar compression and vascular necrosis). Conclusions Our results suggest the study of MM patients should include WB-MR and/or 18 F-FDG PET/CT, whereas SS is only useful for the skull. Whole-body MR and 18 F-FDG PET/CT are complementary techniques, because both of them show good concordance in almost every location. It is still necessary to individualize the indication of each technique according to patient characteristics.
Aldehyde dehydrogenase inhibitors promote DNA damage in ovarian cancer and synergize with ATM/ATR inhibitors
Authors: Edward Grimley, Alexander J Cole, Thong T Luong, Stacy C McGonigal, Sarah Sinno, Dongli Yang, Kara A Bernstein, Ronald J Buckanovich
Journal: Theranostics (2021)

Rationale: Aldehyde dehydrogenase (ALDH) enzymes are often upregulated in cancer cells and associated with therapeutic resistance. ALDH enzymes protect cells by metabolizing toxic aldehydes which can induce DNA double stand breaks (DSB). We recently identified a novel ALDH1A family inhibitor (ALDHi), 673A. We hypothesized that 673A, via inhibition of ALDH1A family members, could induce intracellular accumulation of genotoxic aldehydes to cause DSB and that ALDHi could synergize with inhibitors of the ATM and ATR, proteins which direct DSB repair. Methods: We used immunofluorescence to directly assess levels of the aldehyde 4-hydroxynonenal and comet assays to evaluate DSB. Western blot was used to evaluate activation of the DNA damage response pathways. Cell counts were performed in the presence of 673A and additional aldehydes or aldehyde scavengers. ALDH inhibition results were confirmed using ALDH1A3 CRISPR knockout. Synergy between 673A and ATM or ATR inhibitors was evaluated using the Chou-Talalay method and confirmed in vivo using cell line xenograft tumor studies. Results: The ALDHi 673A cellular accumulation of toxic aldehydes which induce DNA double strand breaks. This is exacerbated by addition of exogenous aldehydes such as vitamin-A (retinaldehyde) and ameliorated by aldehyde scavengers such as metformin and hydralazine. Importantly, ALDH1A3 knockout cells demonstrated increased sensitivity to ATM/ATR inhibitors. And, ALDHi synergized with inhibitors of ATM and ATR, master regulators of the DSB DNA damage response, both in vitro and in vivo. This synergy was evident in homologous recombination (HR) proficient cell lines. Conclusions: ALDHi can be used to induce DNA DSB in cancer cells and synergize with inhibitors the ATM/ATR pathway. Our data suggest a novel therapeutic approach to target HR proficient ovarian cancer cells.
Abstract 15970: Examining Patients’ Knowledge With Regards to Peripheral Artery Disease Treatments and Outcomes: Insights From the PORTRAIT Registry
Authors: Jeremy B Provance, John A Spertus, Carole Decker, Kim G Smolderen
Journal: Circulation (2018)

Introduction: Lower extremity peripheral artery disease (PAD) requires multifaceted disease management to lower cardiovascular risk and to obtain symptom relief, most of which requires active engag...
Public Health Interventions, Epidemic Growth, and Regional Variation of the 1918 Influenza Pandemic Outbreak in a Swiss Canton and Its Greater Regions
Authors: Kaspar Staub, Peter Jüni, Martin Urner, Katarina L. Matthes, Corina Leuch, Gina Gemperle, Nicole Bender, Sara I. Fabrikant, Milo Puhan, Frank Rühli, Oliver Gruebner, Joël Floris
Journal: Annals of Internal Medicine (2021)

Public health interventions implemented during the coronavirus disease 2019 (COVID-19) pandemic are based on experience gained from past pandemics. The 1918 influenza pandemic is the most extensively researched historical influenza outbreak. All 9335 reports available in the State Archives on 121 152 cases of influenza-like illness from the canton of Bern from 473 of 497 municipalities (95.2%) were collected; the cases were registered between 30 June 1918 and 30 June 1919. The overall incidence rates of newly registered cases per week for the 9 greater regions of Bern for both the first and second waves of the pandemic were calculated. Relative incidence rate ratios (RIRRs) were calculated to estimate the change in the slope of incidence curves associated with public health interventions. During the first wave, school closures (RIRR, 0.16 [95% CI, 0.15 to 0.17]) and restrictions of mass gatherings (RIRR, 0.57 [CI, 0.54 to 0.61]) were associated with a deceleration of epidemic growth. During the second wave, in autumn 1918, cantonal authorities initially reacted hesitantly and delegated the responsibility to enact interventions to municipal authorities, which was associated with a lack of containment of the second wave. A premature relaxation of restrictions on mass gatherings was associated with a resurgence of the epidemic (RIRR, 1.18 [CI, 1.12 to 1.25]). Strikingly similar patterns were found in the management of the COVID-19 outbreak in Switzerland, with a considerably higher amplitude and prolonged duration of the second wave and much higher associated rates of hospitalization and mortality.
Dual-ligand supramolecular nanofibers inspired by the renin-angiotensin system for the targeting and synergistic therapy of myocardial infarction
Authors: Zhanpeng Wen, Jie Zhan, Hekai Li, Guanghui Xu, Shaodan Ma, Jianwu Zhang, Zehua Li, Caiwen Ou, Zhimou Yang, Yanbin Cai, Minsheng Chen
Journal: Theranostics (2021)

Rationale: The compensatory activation of the renin-angiotensin system (RAS) after myocardial infarction (MI) plays a crucial role in the pathogenesis of heart failure. Most existing studies on this subject focus on mono- or dual-therapy of blocking the RAS, which exhibit limited efficacy and often causes serious adverse reactions. Few studies have been conducted on targeted therapy based on the activated RAS post-MI. Thus, the development of multiple-functional nanomedicine with concurrent targeting ability and synergistic therapeutic effect against RAS may show great promise in improving cardiac function post-MI. Methods: We utilized a cooperative self-assembly strategy constructing supramolecular nanofibers- telmisartan-doped co-assembly nanofibers ( TDCNfs ) to counter-regulate RAS through targeted delivery and combined therapy. TDCNfs were prepared through serial steps of solvent exchange, heating incubation, gelation, centrifugation, and lyophilization, in which the telmisartan was doped in the self-assembly process of Ang1-7 to obtain the co-assembly nanofibers wherein they act as both therapeutic agents and target-guide agents. Results: TDCNfs exhibited the desired binding affinity to the two different receptors, AT1R and MasR. Through the dual ligand-receptor interactions to mediate the coincident downstream pathways, TDCNfs not only displayed favorably targeted properties to hypoxic cardiomyocytes, but also exerted synergistic therapeutic effects in apoptosis reduction, inflammatory response alleviation, and fibrosis inhibition in vitro and in vivo, significantly protecting cardiac function and mitigating post-MI adverse outcomes. Conclusion: A dual-ligand nanoplatform was successfully developed to achieve targeted and synergistic therapy against cardiac deterioration post-MI. We envision that the integration of multiple therapeutic agents through supramolecular self-assembly would offer new insight for the systematic and targeted treatment of cardiovascular diseases.
Anti‐Bacterial Hydrogels: A Hydrogen‐Bonded Extracellular Matrix‐Mimicking Bactericidal Hydrogel with Radical Scavenging and Hemostatic Function for pH‐Responsive Wound Healing Acceleration (Adv. Healthcare Mater. 3/2021)
Authors: Zainab Ahmadian, Alexandra Correia, Masoud Hasany, Patrícia Figueiredo, Faramarz Dobakhti, Mohammad Reza Eskandari, Seyed Hojjat Hosseini, Ramin Abiri, Shiva Khorshid, Jouni Hirvonen, Hélder A. Santos, Mohammad‐Ali Shahbazi
Journal: Advanced Healthcare Materials (2021)

Extracellular matrix-mimicking hydrogels with antioxidant, hemostasis, and antibacterial properties offer translating avenues towards wound repair through the promotion of fibroblast proliferation. In article number 2001122 by Hélder A. Santos, Mohammad-Ali Shahbazi, and co-workers, hydrogen bonding among the functional groups of gelatin and tannic acid creates a biocompatible hydrogel, where the improvement of re-epithelialization and collagen deposition are its main features to treat full-thickness wounds.
Seroprevalence of antibodies against SARS-CoV-2 in a large national hospital and affiliated facility in Tokyo, Japan
Authors: Akihito Tanaka, Shohei Yamamoto, Kengo Miyo, Tetsuya Mizoue, Kenji Maeda, Wataru Sugiura, Hiroaki Mitsuya, Haruhito Sugiyama, Norio Ohmagari
Journal: Journal of Infection (2021)
Abstract 16190: Trends in Admissions and Outcomes in Patients With Chronic Limb-threatening Ischemia-a National Inpatient Sample Analysis
Authors: Mahesh Anantha Narayanan, Rajkumar P Doshi, Krunalkumar Patel, Azfar B Sheikh, Fiorella Llanos-Chea, Jinnette D Abbott, Raul J Guzman, Mehdi H Shishehbor, William R Hiatt, Sue Duval, Carlos Mena-hurtado, Kim G Smolderen
Journal: Circulation (2020)

Introduction: Chronic limb threatening ischemia (CLTI) morbidity and mortality rates have historically been higher, however recent trends have not been reported. In patients admitted with CLTI, we aimed to examine trends in in-hospital mortality, major amputations, length of stay, and cost of admissions overall, and stratified by type of revascularization procedures. Hypothesis: We hypothesized there would be an increase in CLTI-related admissions, with outcomes only marginally improving. Methods: Using 2011-2017 National Inpatient Sample data, we identified CLTI-related admissions based on ICD-9 and 10-CM codes. We stratified outcomes based on endovascular or open surgical interventions. We also performed multivariable regression analyses based on age, sex, race, hospital size, type and location. Results: We identified 2,643,087 CLI-related admissions between 2011 and 2017. CLI admissions increased from 0.9% to 1.4% P trend &lt;0.0001 as well as overall PAD admissions (4.5% to 8.9%, P trend &lt;0.0001). In-hospital mortality for the entire CLTI cohort decreased from 3.3% to 2.7%, P trend &lt;0.0001 and major amputations decreased from 10.9% to 7%, P trend &lt;0.0001. A decline was also noted for length of stay from 5.7 (3.1-10.1) to 5.4 (3.0-9.2) (P trend &lt;0.0001), whereas admission costs increased from 11,791 (6,676 - 21,712) to 12,597 (7,248 - 22,748) (P trend &lt;0.0001). The volume of endovascular interventions increased (P&lt;0.0001) against a decline in surgical interventions (P&lt;0.0001). Black race, female sex and age ≥60 years were associated with higher in-hospital mortality. Conclusions: A relatively small decrease in absolute numbers for mortality and major amputations were observed against a backdrop of increasing CLTI admission volumes over recent years. As patients with CLTI receive more endovascular interventions than surgical interventions over time, mortality rates and length of stay have generally improved.
What’s Wrong With You?
Authors: Caren J. Blacker
Journal: JAMA Neurology (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Sixty seconds on . . . Contagion
Authors: Gareth Iacobucci
Journal: BMJ (2021)

As in, when a disease is spread by touching someone or something?Well, yes.But the term contagion can also refer to situations in which ideas spread from one place to another.Which brings us neatly on to Matt Hancock. Has he been spreading the gospel about technology again?No, not this time.England's health secretary has in fact revealed that the UK's swift response to rolling out a vaccine for covid-19 was influenced by Contagion, the 2011 Steven Soderbergh film starring Gwyneth Paltrow and Matt Damon, which is about the spread of a deadly virus and the ensuing global response. Sounds eerily familiarIndeed.There was a surge in interest in the film last year because of covid-19, and Hancock clearly picked something up after watching it.He told LBC Radio 1 that after observing the film's portrayal of the huge scramble for the vaccine once it became available, he insisted the UK order 100m doses of the Oxford AstraZeneca vaccine, rather than 30m. How does this fit in with "following the science"?Hancock insisted that the Hollywood blockbuster was not his "primary" source of advice, but he said it did open his eyes to the "huge" demand for a vaccine once approved."He would keep referring to the end of the film," one former Department of Health adviser told Sky News. 2 Wow. Is Hancock after part in Contagion 2?Well, Soderburgh has revealed that he is working on what he described as a "philosophical sequel" to Contagion, but set in a different context.If that context requires an enthusiastic go getting individual with a love of apps, then maybe Hancock could be the new Damon. Does he have any acting experience?Based on a recent TV clip 3 in which he cried at the news of the first covid-19 vaccine being delivered, a mid-career transition from the green benches to the silver screen might not be out of the question. 1 Grafton-Green P. Matt Hancock tells LBC how film Contagion alerted him to global vaccine scramble.LBC. 3 February 2021.www.lbc.co
Gyandev Punyadev Sheth
Authors: Hiten G Sheth
Journal: BMJ (2021)

Gyandev Punyadev Sheth was born in India. He and his wife, Jyotika, moved to England in 1973 after initial ophthalmology training in Ahmedabad, Gujarat. He spent further happy years in training posts in England (Wolverhampton and Exeter), Wales (St Asaph), and Scotland (Tennent Institute, Glasgow). He then held various locum …
Testimony of the Beirut Explosion—A White Coat Soaked in Blood and Tears
Authors: Bachar El-Baba
Journal: JAMA Internal Medicine (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Biomarkers for Desensitization in Patients Undergoing Sublingual Immunotherapy for Peanut Allergy
Authors: Suzanne Barshow, Barry Hurlburt, Jane McBride, Soheila Maleki, Ping Ye, Quefeng Li, A. Wesley Burks, Michael Kulis, Edwin Kim
Journal: Journal of Allergy and Clinical Immunology (2021)
Covid-19: social and behavioural responses to chaotic decision making
Authors: Koula Asimakopoulou, Neil Coulson, Dave Gilbert, Sasha Scambler
Journal: BMJ (2021)

“Chaotic decision making,” as well as undermining the government’s response to the pandemic,1 also lowers behavioural adherence to lockdown restrictions.

Lockdown adherence can be compromised by comparative optimism fuelled beliefs,2 such as “covid will affect others, but not me”34 and “if it has not happened yet, it is unlikely to happen now.”5 This comparative optimism is an ongoing threat to lockdown adherence, potentially augmented by the knowledge …