tbuckley/cabot-search huggingface dataset:
From the authors:
Authors: O. Oxlade, D. Menzies
Journal: European Respiratory Journal (2011)

Predicting outcomes and drug resistance with new standardised treatmentTo the Editors:In their hypothetical cohorts OXLADE et al.[1] predicted significant public-health benefits by changing from the 8-month to the 6-month (2HRZE/6HE to 2HRZE/4HR; where H5isoniazid, R5rifampicin, Z5pyrazinamide and E5ethambutol) regimen.Data from 2008 on drug-resistance surveillance from five World Health Organization (WHO) regions, i.e.Africa (Botswana), Western Pacific (China), Africa (Mozambique), South-East Asia (Burma) and Europe (Tajikistan), has shown isoniazid resistances among newly diagnosed cases varies from 9.0% to 26.6% and among previously treated cases from 11.7% to 74.4% [2].India and China carry the greatest estimated burden of multidrugresistant (MDR)-tuberculosis (TB), together accounting for almost 50% of the total cases worldwide [2] The incidence of mono-drug resistance among new cases in tuberculosis endemic countries is also high [3].Relapse cases (from all previously mentioned sites) had 5.5 times higher odds of harbouring MDR-TB strains when compared with new cases (95% CI 4.4-6.8),after adjusting for the clustering effect at the country level [2].
Hydrogen peroxide contrast echocardiography: quantification in vivo of myocardial risk area during coronary occlusion and of the necrotic area remaining after myocardial reperfusion.
Authors: A JKemper, J EO'Boyle, C ACohen, ATaylor, A FParisi
Journal: Circulation (1984)

During sustained coronary occlusion in canine preparations, the extent of regions that fail to show contrast enhancement when imaged by supra-aortic hydrogen peroxide contrast echocardiography (SHPCE) has been shown to correlate well for single cross sections with the extent of malperfused myocardium   of infarction. In the present study, SHPCE was investigated as a means of determining the fraction of total left ventricular mass at risk during occlusion. Since necrotic tissue has low blood flow even when reperfused, we also investigated the potential of quantitating the extent of infarcted myocardium by measuring the extent of contrast defects seen with SHPCE performed during reperfusion. In 20 dogs the fraction of the left ventricle showing a contrast defect during coronary occlusion correlated well with the fraction of the left ventricular mass   by an autoradiographic technique (autoradiography = 0.83 echocardiography + 8.6%; r = .89, SEE = 4.5%). SHPCE was also performed after 3 hr of...
Evaluation of a Strength-Training Program on Clinical Outcomes in Older Adults
Authors: Johannes Burtscher, Grégoire P. Millet, Martin Burtscher
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparison of cardiovascular responses to static-dynamic effort and dynamic effort alone in patients with chronic ischemic heart disease.
Authors: RDeBusk, WPitts, WHaskell, NHouston
Journal: Circulation (1979)

Thirty men, mean age 55 years, known to have treadmill-induced ischemic ST-segment depression, performed static and dynamic effort, i.e., forearm lifting and treadmill exercise, separately and combined. Static effort was sustained at 20%, 25% or 30% of maximal forearm lifting capacity. Two symptom-limited treadmill tests, one with and one without added static effort, were performed on each of two visits. Compared with dynamic effort alone, combined static-dynamic effort decreased treadmill work load and increased heart rate, systolic blood pressure and rate-pressure product at the onset of ischemic ST-segment depression or angina pectoris: 7.1 +/- 0.4 vs 8.0 +/- 0.5 (SEM) multiples of resting oxygen consumption (mets), estimated; 141 +/- 3 vs 134 +/- 3 beats/min; 170 +/- 4 vs. 162 +/- 4 mm Hg and 239 +/- 8 vs 218 +/- 9 (p less than 0.001). The prevalence of angina pectoris was significantly less with combined static-dynamic effort than with dynamic effort alone. Static effort causes a resetting of the thr...
Recurrent Subcutaneous Ewing Sarcoma on 18F-FDG PET/CT
Authors: Junhao Wu, Ya Liu, Weidong Gong, Taiping Liao, Chunyin Zhang
Journal: Clinical Nuclear Medicine (2021)

Subcutaneous Ewing sarcoma is very rare. This report presents the case of a 23-year-old woman with a history of primary subcutaneous Ewing sarcoma who recently found a gradually increasing mass. Recurrent subcutaneous Ewing sarcoma was thus suspected. 18F-FDG PET/CT was performed and showed an FDG-avid mass in her buttocks. Subsequent histopathological and immunohistochemical tests were consistent with subcutaneous Ewing sarcoma.
Survey-Based Investigation Of Potential Organisational Issues Associated With Reusable Colonoscopes And Gastroscopes in Europe
Authors: S Larsen, L Klinten Ockert, D Kryger Rindorf, S Adamsen
Journal: Endoscopy (2021)

Aims Disposable endoscopes are entering the market as an attempt to ease potential availability, portability, and degradation issues associated with reusable colonoscopes and gastroscopes (rCG). We aimed to identify potential organisational issues associated with rCG.
Clonal Tracking of the Source of Red Cell and Platelet Production in Rhesus Macaques
Authors: Xing Fan, Chuanfeng Wu, Diego Espinoza, Stephanie Sellers, Aylin Bonifacino, Robert E Donahue, Luca Schifanella, Genoveffa Franchini, Cynthia E Dunbar
Journal: Blood (2017)
Relation between physical training and ambulatory blood pressure in stage I hypertensive subjects. Results of the HARVEST Trial. Hypertension and Ambulatory Recording Venetia Study.
Authors: PPalatini, G RGraniero, PMormino, LNicolosi, LMos, PVisentin, A CPessina
Journal: Circulation (1994)

BACKGROUNDThis study was undertaken to assess whether ambulatory blood pressure (BP) in a population of stage I hypertensive individuals was lower in the subjects performing regular exercise training.METHODS AND RESULTSThe study was carried out in 796 young hypertensive patients (592 men) who had never been treated who took part in the HARVEST trial. The diagnosis of stage I hypertension was made on the basis of six office BP measurements. Subjects underwent noninvasive 24-hour ambulatory BP monitoring, 24-hour urine collection for catecholamine assessment, and echocardiography (n = 457). They were classified as exercisers if they reported at least one session of aerobic sports per week and as nonexercisers if they did not engage regularly in sports activities. Age (P < .0001), body mass index (P = .002), 24-hour heart rate (P < .0001), alcohol intake (P = .02), smoking (P = .02), and norepinephrine output (P = .04) were lower in the active (n = 153) than the inactive (n = 439) men. Physically active men ...
Quantitative studies on plasmalemmal folds and caveolae of rabbit ventricular myocardial cells.
Authors: K RLevin, EPage
Journal: Circulation Research (1980)

Plasmalemmal folds and caveolae were investigated by qualitative and quantitative analysis of electron micrographs obtained by freeze fracture and transmission electron microscopy (TEM) of rabbit right ventricular papillary muscles whose mean sarcomere lengths ranged from 1.64 to 2.28 micron. In passively extended muscles, folds were observed at sarcomere lengths of 2.3 micron and could be shown by extrapolation to become completely extended at a maximum sarcomere length of 2.8 micron. It was concluded that the plasmalemma does not contribute to resting tension in the physiological range of sarcomere lengths. Caveolae are present in both the external plasmalemmal envelope and T-tubular plasmalemma. They show no preferential distribution with respect to underlying myofibrillar striations or membrane folds and are nearly devoid of membrane particles in freeze-fractured material. The surface density of caveolar necks (4.0/micron2 apparent plasmalemmal area) is only 16-20% of that reported for frog skeletal m...
The New Generation of Mirocam Express View is Highly Accurate and Effective to Reduce the Capsule Endoscopy Reading Time
Authors: S Piccirelli, A Mussetto, A Bellumat, R Cannizzaro, M Pennazio, A Pezzoli, A Bizzotto, N Fusetti, F Valiante, C Spada
Journal: Endoscopy (2021)

Aims CE reading is time-consuming and still represents a main limitation in CE. A new generation Express View(EV) algorithm has been disegned by Mirocam to shorten CE videos. Primary aim was to evaluate EV diagnostic accuracy in detection of small bowel lesions. Secondary objective was to compare median reading time in EV mode vs Standard Reading(SR)
Identification and Clinical Exploration of Individualized Targeted Therapeutic Approaches in Acute Myeloid Leukemia Patients By Integrating Drug Response and Deep Molecular Profiles
Authors: Disha Malani, Ashwini Kumar, Bhagwan Yadav, Mika Kontro, Swapnil Potdar, Samuli Eldfors, Jani Saarela, Bjørn Tore Gjertsen, Riikka Karjalainen, Tero Aittokallio, Astrid Murumagi, Maija Wolf, Simon Anders, Krister Wennerberg, Caroline A Heckman, Kimmo Porkka, Olli Kallioniemi
Journal: Blood (2017)
酸化ストレス応答性アポトーシス誘導蛋白質(ORAIP)は低酸素/再酸素化に応答性のニューロンアポトーシスを仲介する
Authors: Seko Yoshinori, Yao Takako, Fukuda Shuichi, Fujimura Tsutomu, Murayama Kimie
Journal: Circulation (2010)
Successful surgical excision of focal paroxysmal atrial tachycardia. Observations in vivo and in vitro.
Authors: C RWyndham, M FArnsdorf, SLevitsky, T CSmith, R CDhingra, PDenes, K MRosen
Journal: Circulation (1980)

A 41-year-old man had chronic, recurrent, drug-resistant paroxysmal right atrial tachycardia. Electrophysiologic studies revealed features suggesting atrial reentrance, including induction and termination of tachycardia with rapid atrial pacing and atrial extrastimuli. Endocardial catheter mapping localized the origin of tachycardia to the right atrial appendage. Intraoperative epicardial mapping refined the localization to the posterolateral rim of the appendage. The appendage was excised and the tachycardia was permanently cured. Microelectrode studies on the excised tissue revealed an inducible rhythm localized to a small area of the atrial endocardium, characterized by rapid pacing induction, rhythmicity generated from a suprathreshold afterdepolarization, low maximum diastolic potential, low overshoot potential and a smooth transition from phase 4 to phase 0, suggesting triggered automaticity. This is the first observation in man of probable triggerable atrial automaticity, which may be a direct coun...
Abstract 16816: Direct Oral Anticoagulants Compared to Warfarin for the Treatment of Left Ventricular Thrombus: A Multi-Center Experience
Authors: Andrei Minciunescu, Naila Ijaz, Nisha Donthi, Leonard D Genovese, Behnam N Tehrani, Henry A Tran
Journal: Circulation (2020)

Introduction: Left ventricular thrombus (LVT) is associated with high risk of major adverse cardiovascular events (MACE) and mortality. Although warfarin is standard of care for LVT prevention and treatment, there is rising interest in the role of direct oral anticoagulants (DOACs). The goal of this study is to evaluate clinical outcomes of patients with LVT treated with DOACs compared to those treated with warfarin. Methods: Patients within a regional, multi-center health care system diagnosed with LVT from 2014-2018 were retrospectively identified through search of the electronic medical record. Demographic data, comorbidities, anticoagulation treatment, ejection fraction, and LVT etiology were recorded. Clinical outcomes including LV thrombus resolution, bleeding, and all-cause mortality were determined. Results: Demographic data is summarized in Table 1. Of 212 identified patients, 140 (66%) were treated with warfarin, 57 (26.9%) with DOAC, and 7 (3.3%) with low molecular weight heparin. Of these, 158 (74.5%) were on concomitant antiplatelet therapy. One patient was treated with antiplatelet therapy alone, and 7 patients received neither anticoagulation nor antiplatelet therapy. Patients treated with DOAC had no significant differences compared to those treated with VKA with respect to LVT resolution (69.3% vs 64.9, p = 0.95), hemorrhagic stroke (2.1% vs 1.8%, p = 0.86), ischemic stroke (2.1% vs 3.5%, p = 0.58), significant bleed (9.2% vs 12.3%, p = 0.78), and all-cause mortality (13.6% vs 15.8%, p = 0.17). Conclusions: In this large, multi-center retrospective study, clinical outcomes and adverse events of patients treated with DOAC for LVT are similar to VKA-treated patients. Given the observational nature of this study, randomized controlled studies are needed to validate these findings.
Hypertension and ascorbic acid (multiple letters)
Authors: A. Ness, J. Sterne, G. Rolla, L. Brussino, R. Carra, E. Garbella, C. Bucca, J. B. Kostis, A. C. Wilson, C. R. Lacy, A. Ceriello, E. Motz, D. Giugliano, U. N. Das, S. J. Duffy, J. A. Vita
Journal: The Lancet (2000)
KDM5 inhibition offers a novel therapeutic strategy for the treatment of <i>KMT2D</i> mutant lymphomas
Authors: James Heward, Lola Koniali, Annalisa D’Avola, Karina Close, Alison Yeomans, Martin Philpott, James Dunford, Tahrima Rahim, Ahad F. Al Seraihi, Jun Wang, Koorosh Korfi, Shamzah Araf, Sameena Iqbal, Findlay Bewicke-Copley, Emil Kumar, Darko Barisic, Maria Calaminici, Andrew Clear, John Gribben, Peter Johnson, Richard Neve, Pedro Cutillas, Jessica Okosun, Udo Oppermann, Ari Melnick, Graham Packham, Jude Fitzgibbon
Journal: Blood (2021)
Influence of acute alterations in heart rate and systemic arterial pressure on echocardiographic measures of left ventricular perfornmance in normal human subjects.
Authors: JHirshleifer, MCrawford, R AO'Rourke, J SKarliner
Journal: Circulation (1975)

To study the effects of acute alterations in heart rate and systemic arterial pressure on the mean velocity of left ventricular circumferential fiber shortening (Vcf) and on mean posterior wall velocity (Vpw), we performed ultrasound studies in 25 normal human subjects between the ages of 21 and 29 years. When heart rate was augmented by the administration of intravenous atropine from 64 +/- 2.2 (SEM) to 98 +/- 2.7 beats/min, mean normalized Vcf increased from 1.22 +/- 0.05 to 1.38 +/- 0.06 circumferences (circ)/sec(P less than 0.001). Mean normalized Vpw increased from 0.76 +/- 0.03 to 0.89 +/- 0.04 sec-1 (P less than 0.001). Mean Vcf and mean Vpw uncorrected for end-diastolic diameter increased in a similar fashion (P less than 0.01). After atropine administration, systemic arterial pressure was augmented by means of a phenylephrine infusion in 23 subjects by an average of 39 mm Hg (range 20-50 mm Hg). During the phenylephrine infusion, average heart rate decreased from 96 +/- 2.6 to 91 +/- 3.1 beats/mi...
8th European Conference on Infections in Leukaemia: 2020 guidelines for the use of antibiotics in paediatric patients with cancer or post-haematopoietic cell transplantation
Authors: Thomas Lehrnbecher, Dina Averbuch, Elio Castagnola, Simone Cesaro, Roland A Ammann, Carolina Garcia-Vidal, Jukka Kanerva, Fanny Lanternier, Alessio Mesini, Malgorzata Mikulska, Dorothea Pana, Nicole Ritz, Monica Slavin, Jan Styczynski, Adilia Warris, Andreas H Groll
Journal: The Lancet Oncology (2021)
18F-FET PET/CT in Early Subventricular Zone Recurrence of Adult Glioblastoma
Authors: Gurvan Dissaux, Brieg Dissaux, David Bourhis, Ulrike Schick, Solène Querellou
Journal: Clinical Nuclear Medicine (2021)

Abstract Glioma stem cells (GSCs) are the source of tumor recurrence in glioblastoma and are capable of whole tumor regeneration once the treatment has concluded. Compelling evidence from the last decade suggests that GSC may arise from neural stem cells residing in the adult subventricular zone (SVZ). We report the findings of an 18 F-FET PET/CT showing pathological uptake in SVZ with a tumor-background ratio of greater than 1.6, giving evidence for glioblastoma recurrence. This case highlights the particular attention to be paid to the SVZ given the possible development of GSC.
The effects of oral hydralazine on right ventricular end-diastolic pressure in patients with right ventricular failure.
Authors: L JRubin, FHandel, R HPeter
Journal: Circulation (1982)

Hydralazine reduces pulmonary vascular resistance in patients with primary and secondary pulmonary hypertension, but the effects on right ventricular function of a change in resistance without a reduction in pulmonary arterial pressure are not known. We evaluated the hemodynamic effects of hydralazine, 50 mg, administered orally every 6 hours for 48 hours in 14 patients with right ventricular failure and pulmonary hypertension resulting from various causes. Hydralazine reduced mean right ventricular end-diastolic pressure from 17.4 +/- 5.6 to 11.6 +/- 5.3 mm Hg (p less than 0.001) and increased cardiac output and stroke volume by more than 40%. In nine patients who had no change in mean pulmonary arterial pressure after hydralazine, total pulmonary resistance decreased from 15.9 +/- 6.0 to 10.6 +/- 4.3 (p less than 0.001) and cardiac index increased from 2.07 +/- 0.51 to 2.97 +/- 0.91 (p less than 0.005). There was a close correlation between the reductions in total pulmonary resistance and right ventricu...
Right atrial and right ventricular transmural pressures in dogs and humans. Effects of the pericardium.
Authors: D RHamilton, R SDani, R ASemlacher, E RSmith, T MKieser, J VTyberg
Journal: Circulation (1994)

BACKGROUNDTo determine the transmural pressure-dimension relations of the right atrium (RA) and right ventricle (RV) before and after pericardiectomy, six open-chest dogs were instrumented with pericardial balloons placed over the RA and RV free walls.METHODS AND RESULTSPA appendage dimensions and RV free-wall segment lengths were measured using sonomicrometry. Intact-pericardium RA and RV transmural pressures were calculated by subtracting the pericardial pressures (measured using balloons) from the cavitary pressures. Pooled data from six animals with pericardium intact indicate that at RA and RV cavitary pressures of 5, 10, and 15 mm Hg, RV pericardial pressure was 4.3 +/- 0.3, 8.6 +/- 1.0, and 13.3 +/- 1.5 mm Hg, respectively, and RA pericardial pressure was 4.8 +/- 0.3, 9.6 +/- 0.6, and 14.6 +/- 0.6 mm Hg, respectively (mean +/- SD). With calculated unstressed dimensions, the cavity dimension data were normalized to strain (in percent). We determined that in the dog, RV strain would increase by 14% a...
Coordination of mural elements and myofilaments during arteriolar constriction.
Authors: G ESleek, B RDuling
Journal: Circulation Research (1986)

Arterioles undergo major morphological changes during vasoconstriction. We used transmission electron microscopy to study wall morphology in both dilated and constricted microvessels to understand the cellular basis of these changes. The relation between the orientation and density of myofilaments and the distribution of dense bodies was analyzed with respect to the level of microvessel tone. The data show a strong correlation between the degree of arteriolar constriction and both the orientation and density of myofilaments. In dilated arterioles, myofilament orientation was predominantly circumferential across the entire smooth muscle cell, averaging 84 +/- 2 degrees (SEM) relative to a radial reference line. In vessels constricted to 50% of their maximal diameter, myofilament orientation was dependent upon the location within the cell, being largely circumferential at the adventitial border (77 +/- 4 degrees) and shifting to a radial arrangement at the intimal border (36 +/- 5 degrees). The reorganizati...
Relationship of regional myocardial perfusion to segmental wall motion: a physiologic basis for understanding the presence and reversibility of asynergy.
Authors: B MMassie, E HBotvinick, B HBrundage, BGreenberg, DShames, HGelberg
Journal: Circulation (1978)

Experimental work has shown that even small reductions in myocardial perfusion impair contractile performance. We, therefore, studied the relationship between regional perfusion, assessed by thallium-201 scintigraphy and segmental wall motion, quantitated on biplane contrast ventriculograms, in patients with coronary artery disease. We evaluated 270 segments in 54 patients, including 27 without evidence of myocardial infarction. Most normally perfused regions (125 of 140) contracted normally, whereas those with scintigraphic defects at rest were usually asynergic (42 of 46). Surprisingly, 57% (48 of 84) of regions with exercise-induced perfusion defects were also asynergic, including 48% (25 of 52) of those in patients without myocardial infarction. In 22 patients who had intervention ventriculograms, improvement of perfusion abnormalities at rest correlated closely with reversibility of asynergy. Although there was an association between the location and severity of coronary artery stenosis and segmental...
Intermediate-term effectiveness of balloon valvuloplasty for congenital aortic stenosis. A prospective follow-up study.
Authors: B KO'Connor, R HBeekman, A PRocchini, ARosenthal
Journal: Circulation (1991)

BACKGROUNDPercutaneous balloon valvuloplasty has proven to be acutely effective in the treatment of congenital valvar aortic stenosis; however, the intermediate- and long-term effectiveness of the procedure remain to be documented.METHODS AND RESULTSTo assess the intermediate-term effectiveness of balloon valvuloplasty, repeat catheterization was performed in 27 of 30 children 1.7 +/- 0.1 years after balloon valvuloplasty for congenital aortic stenosis (AS). In 33 children the peak AS gradient was reduced acutely by 55% from 77 +/- 4 to 35 +/- 3 mm Hg (p less than 0.001), and left ventricular systolic pressure was reduced from 176 +/- 4 to 138 +/- 4 mm Hg (p less than 0.001). Despite a technically adequate valvuloplasty procedure, three patients had inadequate relief of obstruction and required complex surgical intervention. Twenty-seven of the 30 patients available for late reevaluation (90%) enrolled in the follow-up study. The peak AS gradient remained significantly reduced compared with that present b...
Relevance of location of defect and pulmonary vascular resistance to the intracardiac pattern of left-to-right shunt flow in dogs with experimental ventricular septal defect.
Authors: SOkubo, MNakai, TTomino
Journal: Circulation (1986)

Left-to-right (L-R) shunting across a ventricular septal defect (VSD) often involves a direct VSD-pulmonary arterial component (jet) that surges from the VSD immediately into the pulmonary artery. We used the thermodilution technique in dogs with acute experimental VSD to quantify this component. In dogs with supracristal VSD (n = 7), the direct component represented 76 +/- 4% (mean +/- SE) of the total L-R shunt on average, vs 39 +/- 7% (p less than .001) of the total in dogs with infracristal VSD and the same level of L-R shunting (n = 6). The direct component can be expected to impose additional hyperkinetic forces on the pulmonary artery since it is driven by the left ventricular pressure. Although not yet clinically proven, we speculate therefore that patients with supracristal VSD may be at greater risk of becoming jeopardized by late-onset pulmonary vascular obstructive disease. Since a part of the total shunt other than the direct component dropped into the right ventricle, the right ventricle bor...