tbuckley/cabot-search huggingface dataset:
Establishing the severity of personality disorder
Authors: P Tyrer, T Johnson
Journal: American Journal of Psychiatry (1996)

The authors developed a simplified method of rating the severity of personality disorder.The new rating method is based on four levels of severity: no personality disorder, personality difficulty, simple personality disorder, and diffuse personality disorder. The new method was applied to different diagnostic systems and was then compared with an old rating system based on six severity levels. Data were derived from a longitudinal study in which 163 patients with anxiety and depressive disorders had initial assessments of personality status and were followed up over 2 years. Ratings of psychiatric symptoms were made by using the Comprehensive Psychopathological Rating Scale over this period. The results were analyzed with special attention to linear and quadratic trends.The new system was clinically useful in separating patients' initial assessments and outcomes. Patients with no personality disorder had the lowest initial symptom scores and the best outcomes, and those with diffuse personality disorder had the highest initial levels of symptoms and improved least over the 2 years. When the patients were separated by the old classification system, 72% of the variation between groups was accounted for by linear and quadratic trends; the comparable percentage was 97% when the patients were categorized by the new system.The new system of rating severity of personality disturbance is an improvement on existing methods and allows ratings to be made easily from DSM-IV and ICD-10.
Are selective COX 2 inhibitors superior to traditional NSAIDs?
Authors: B. R Budenholzer
Journal: BMJ (2002)

# Rofecoxib did not provide unequivocal benefit over traditional NSAIDs {#article-title-2} EDITOR—In their editorial Jüni et al say that celecoxib is no safer than diclofenac or ibuprofen and that the CLASS authors “spun” their analysis to suggest otherwise.1 They also state: “In contrast with the CLASS trial, the VIGOR trial, which was similar in design and outcomes, found an unequivocal benefit of another selective COX 2 inhibitor, rofecoxib, over traditional non-steroidal anti-inflammatory agents [NSAIDs].”2 I disagree. Although serious gastrointestinal adverse effects were less frequent in rofecoxib users than in patients with rheumatoid arthritis treated with naproxen (number needed to treat to prevent one serious upper gastrointestinal event 191; 95% confidence interval 114 to 586), rofecoxib was in fact less safe than naproxen. The published version of the VIGOR trial focused on the narrow outcome of serious gastrointestinal complications. The US Food and Drug Administration took the unprecedented step of presenting its review of both the CLASS trial and the VIGOR trial on its website.3 Review of the complete data presented there shows that when all serious adverse events are included—not just gastrointestinal events—patients treated with naproxen had fewer serious events. Among patients treated with rofecoxib, 9.3% experienced a serious adverse event compared with 7.8% of those treated with naproxen (relative risk 0.81; 0.62 to 0.97). When all serious adverse events are counted, the number needed to harm when rofecoxib is used compared with naproxen is 66 (36 to 332). The increased risk of serious adverse events was due to an increase of serious adverse cardiovascular events, including a 300% greater risk of myocardial infarction in those treated with rofecoxib. The VIGOR results, examined fully, show that at least one traditional non-steroidal anti-inflammatory drug—naproxen—is unequivocally safer than rofecoxib, albeit with an increased risk of adverse events limited to the gastrointestinal tract. ![Graphic][1]</img>Three other responses on bmj.com (bmj.com/cgi/eletters/324/7349/1287) made similar … [1]: /embed/inline-graphic-1.gif
Schistosoma mansoni excretory circulating cathodic antigen shares Lewis- x epitopes with a human granulocyte surface antigen and evokes host antibodies mediating complement-dependent lysis of granulocytes
Authors: GJ van Dam, FH Claas, M Yazdanbakhsh, YC Kruize, AC van Keulen, ST Ferreira, JP Rotmans, AM Deelder
Journal: Blood (1996)
Abstract 17892: Network-Driven Integrative Genomics Analysis of the Cardiogram Gwas Reveals Key Drivers and Subnetworks of Coronary Artery Disease
Authors: Xia Yang, Tianxiao Huan, Seraya Maouche, Jun Zhu, Bin Zhang, Michael Preuss, Jeanette Erdmann, Christopher P Nelson, Kym I Snell, Ayellet V Segrè, Ruth McPherson, Thomas Quertermous, Nilesh J Samani, Heribert Schunkert, Themistocles L Assimes
Journal: Circulation (2011)

Objective: The molecular mechanisms underlying most CAD susceptibility loci remain unclear and a large proportion of the heritability of CAD remains unexplained. We hypothesize that genetic variation with both strong and subtle effects drives gene subnetworks that affect risk of CAD. Methods: We surveyed CAD related molecular interactions by integrating CARDIoGRAM GWAS associations, expression SNPs (eSNPs), and gene networks constructed from 6 tissues of orthogonal mouse and human studies. We first mapped eSNPs to 12 established CAD gene sets or expression signatures from the literature (positive controls) and 2652 coexpression network modules to derive corresponding eSNP sets. We assessed the degree of enrichment for low p value associations with CAD within each eSNP set using Fisher's exact and Kolmogorov-Smirnov (KS) tests. We screened coexpression modules in the Wellcome Trust case control cohort and took 18 forward for testing in all of CARDIoGRAM. Enriched eSNP sets were in turn integrated with tissue-specific Bayesian networks and a protein-protein interaction (PPI) network to identify central network nodes driving these CAD-related gene sets (key drivers or KDs). Top KDs were then used as seeds to derive subnetworks linking KDs. Results: We found 11 of 12 positive control gene sets and 12 of 18 coexpression network modules to be significantly enriched for eSNPs with low p values (Bonferroni-corrected p&lt;0.05 for both tests). We identified both tissue-specific KDs and KDs common to multiple tissues and found them to be enriched for CAD-related biological processes such as circulation, inflammatory response, and coagulation. The top KDs across tissues are IL1RN, EGR2, NCF2, and LDLR, and the tissue-specific KDs include LPL and APOE from liver, ALOX5AP and ACE from kidney, F7 and ANAX2 from adipose, BACH1 and FER1L3 from blood, and CD36 and PPARG from the PPI network. We found KDs to be highly connected in the networks. We derived representative subnetworks of the top KDs (21 known and 27 novel). Conclusions: Our network-driven integrative analysis not only identified known and novel CAD risk genes but also defined a network structure that sheds light on the molecular interactions of CAD risk genes within, between and across tissues.
Dear Provider
Authors: David Paydarfar, William J. Schwartz
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Unsupported Preference for Intravenous Antibiotics
Authors: Ho Kwong Li, Ambrose Agweyu, Mike English, Philip Bejon
Journal: PLoS Medicine (2015)

Points• Antibiotics that are well absorbed after oral administration are available, and the best current evidence suggests they are safe and effective for many conditions.• Belief in the superiority of intravenous antibiotics is widespread among health professionals and patients, but it is not supported by good evidence.Expanding the evidence base will provide patients and clinicians with further reassurance in specific situations, but reasons for the belief in the strength of intravenous therapy also need to be understood and addressed.
Surveillance des infections à E. coli entérohémorragiques (EHEC) et du syndrome hémolytique et urémique (SHU) en Europe
Authors: A Ammon
Journal: Eurosurveillance (1997)

Depuis leur premiere description (1), les souches d'Escherichia coli O157:H7 et autres E. coli enterohemorragiques (EHEC) sont connues pour etre les principaux agents infectieux responsables des diarrhees hemorragiques. Ces E. coli produisent une ou plusieurs shiga-toxines (stx) ou Vero cytotoxines. Au sens strict, le terme EHEC se rapporte uniquement aux serotypes responsables d'une maladie clinique similaire a celle causee par E. coli O157:H7 et la definition qui considere qu'un E. coli produisant des shiga-toxines est un EHEC n'est pas largement acceptee.
Charlson Comorbidity Index (CCI) and Hematopoietic Cell Transplantation Specific-Comorbidity Index (HCT-CI) Do Not Predict Transplant Related Mortality (TRM) and Post-Transplant Outcomes In Young Patients Undergoing Reduced Intensity Conditioning (RIC) Umbilical Cord Blood (UCB) Transplantation
Authors: Oana V. Paun, Tamila L. Kindwall-Keller, Hillard M. Lazarus, Mary J. Laughlin, Paolo F. Caimi, Merle J. Kolk, Richard J. Creger, Pharm D, Huda Salman, Stanton L. Gerson, Brenda W Cooper
Journal: Blood (2013)
Marine Science: Surf’s Yuck
Authors: Tina Adler
Journal: Environmental Health Perspectives (2004)

To get the real skinny on the health effects of coastal water pollution, talk to a surfer. While catching the waves, surfers are also catching colds, stomach bugs, and more. Surfers long ago made the connection between sick days and urban storm drains dumping untreated runoff from streets, yards, and waterways into beach water. But researchers have now calculated the likelihood of surfers succumbing to waterborne bacteria and viruses.

Environmental scientist Ryan H. Dwight of the University of California, Irvine, and colleagues interviewed 1,873 surfers in two California surfing hot spots: rural Santa Cruz County and urban northern Orange County. The researchers interviewed the surfers in April 1998, following a very wet El Nino winter with greater runoff than usual, and again in April 1999, following a very dry La Nina winter with less runoff than usual.

The first year, Orange County surfers reported almost twice as many symptoms over the previous three months compared with Santa Cruz surfers. Their symptoms included fever, nausea, stomach pain, sore throats, and eye, ear, and skin infections, the team reported in the April 2004 American Journal of Public Health. But even Santa Cruz surfers weren’t entirely safe that spring. Every additional 2.5 hours that surfers in either county spent in the water increased by 10% their likelihood of developing symptoms, the team writes. In the spring following the drier La Nina winter, Orange County surfers reported only slightly more symptoms than Santa Cruz participants.

All of the participants, whose mean age was 30, surfed at least once a week. For their water quality data, the researchers used mean monthly total coliform counts collected by the two counties’ health agencies. Orange County scored much worse on water quality tests in the first year than did Santa Cruz, which is a small, less-developed watershed.

Since the study was done, California has expanded its water quality testing requirements. In 1999, in accordance with updated state standards, California began measuring for enterococci, bacteria that inhabit the intestine. Dwight and others say that although overall water quality may not have improved, the change did result in many more beach closings, particularly in Orange County.

The work by Dwight and colleagues helps confirm in a tangible way what swimmers and surfers know from experience, says Cheryl McGovern, a program manager with the U.S. Environmental Protection Agency in San Francisco. People need studies to quantify the health risks associated with various recreational waters, especially if they will be paying for pollution cleanup, she says. She would like to see a follow-up study that uses more sophisticated water quality data, including measurements of enterococci.

Dwight notes that surfers are not the only people exposed to the waters in these or other coastal counties—several millions of tourists and local residents swim in these waters every year. “If the surfers are getting sick—and they are young and healthy—then the public is at risk as well,” he says.
Preliminary Evidence Of Anti Tumor Activity Of Selinexor (KPT-330) In a Phase I Trial Ofa First-In-Class Oral Selective Inhibitor Of Nuclear Export (SINE) In Patients (pts) With Relapsed / Refractory Non Hodgkin’s Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)
Authors: John Kuruvilla, Martin Gutierrez, Bijal D. Shah, Nashat Y. Gabrail, Peter de Nully Brown, Richard M. Stone, Ramiro Garzon, Michael Savona, David S. Siegel, Rachid Baz, Morten Mau-Sorensen, Matthew S. Davids, John C. Byrd, Sharon Shacham, Tami Rashal, Cindy YF Yau, Dilara McCauley, Jean-Richard Saint-Martin, John McCartney, Yosef Landesman, Boris Klebanov, Greg Pond, Amit M. Oza, Michael Kauffman, Mansoor R Mirza
Journal: Blood (2013)
Preclinical Studies Of SL-401, a Targeted Therapy Directed To The Interleukin-3 Receptor (IL3-R), In Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN): Potent Activity In BPDCN Cell Lines, Primary Tumor, and In An In Vivo Model
Authors: Delettre Fanny, Arthur E. Frankel, Estelle Seilles, Sabeha Biichle, Eric Deconninck, Francis Bonnefoy, Baptiste Lamarthee, Christopher L. Brooks, Eric Rowinsky, Philippe Saas, Francine Garnache Ottou
Journal: Blood (2013)
Eating pathology and DSM-III-R bulimia nervosa: a continuum of behavior
Authors: A Drewnowski, D K Yee, C L Kurth, D D Krahn
Journal: American Journal of Psychiatry (1994)

This longitudinal survey study of 557 college women used the new Eating Pathology Scale to classify respondents as nondieters, casual dieters, intensive dieters, dieters at risk, and bulimic. Shifts in the severity of dieting behavior over a 6-month period occurred primarily between adjacent scale categories. While new cases of bulimia were drawn from intensive dieters and dieters at risk, those women who no longer met DSM-III-R criteria for bulimia nervosa continued to engage in bulimic behavior.
<sup>32</sup>P-Postlabeling Detection of Thymine Glycols: Evaluation of Adduct Recoveries After Enhancement With Affinity Chromatography, Nuclease P1, Nuclease S1, and Polynucleotide Kinase
Authors: M. Vijayaraj Reddy, William T. Bleicher, Gary R. Blackbum
Journal: Cancer Communications (1991)

Thymine glycol (Tg) is a product of DNA damage by oxygen radicals generated by oxidative mutagens and carcinogens and ionizing radiation. The highly sensitive 32P-postlabeling assay was validated and optimized for the measurement of Tg generated in vitro by the reaction of dTp or calf thymus DNA with osmium tetroxide (OsO4). Adduct detection was enhanced by purification of Tg adducts using phenylboronate affinity chromatography or by preferential dephosphorylation of unmodified 3'-nucleotides with nuclease P1, nuclease S1, or polynucleotide kinase; Tg nucleotides were found to be resistant to limited enzymatic 3'-dephosphorylation. Two adducts were seen with OsO4-modified dTp, which may have been cis-Tg adducts, because they were retained on a phenylboronate column, and because OsO4 selectively forms cis-Tg adducts. With OsO4-modified DNA, several adducts were detected, two major derivatives of which coincided chromatographically with those seen in OsO4-modified dTp. The recoveries of major adducts were similar before and after enrichment by different methods, indicating that Tg adducts were resistant to enzymatic dephosphorylation. The efficacy of labeling of the two major Tg adducts by polynucleotide kinase was optimal at 60 microM ATP and higher, whereas it was about 3%, 50%, and 80% of the optimal rate at 2, 10, and 30 microM, respectively. This was in contrast to our previous finding that only 0.25 microM ATP was needed for optimal labeling of benzoquinone-DNA adducts.(ABSTRACT TRUNCATED AT 250 WORDS)
Spectrin Jendouba: an alpha II/31 spectrin variant that is associated with elliptocytosis and carries a mutation distant from the dimer self- association site
Authors: N Alloisio, R Wilmotte, L Morlé, F Baklouti, J Maréchal, MT Ducluzeau, L Denoroy, C Féo, BG Forget, R Kastally, J Delaunay
Journal: Blood (1992)
Multistate outbreak of human Salmonella Typhimurium infections associated with aquatic frogs - United States, 2009.
Authors: J. Hall, M. Poulson, L. Fawcett, S. Cosgrove, K. Lujan, P. Torres, M. Adams-Cameron, K. Winpisinger, J. Yeager, P. Hudecek, E. Hyytia-Trees, N. Garrett, J. Adams, G. Ewald, B. Le, L. Hausman, C. B. Behravesh, I. Williams, S. Sodha, L. Capewell, S. Mettee
Journal: MMWR Morbidity and Mortality Weekly Report (2009)
Glucocorticoids transform CD40-triggering of dendritic cells into an alternative activation pathway resulting in antigen-presenting cells that secrete IL-10
Authors: Delphine Rea, Cees van Kooten, Krista E. van Meijgaarden, Tom H. M. Ottenhoff, Cornelis J. M. Melief, Rienk Offringa
Journal: Blood (2000)
Impact of Plaque Morphology and Vessel Opacification on Quantitative Coronary Angiography with 64-slice Computed Tomography
Authors: Lars Husmann
Journal: Circulation (2007)

Abstract 1771 Lars Husmann, Oliver Gaemperli, Tiziano Schepis, Hans Scheffel, Ines Valenta, Tobias Hoefflinghaus, Paul Stolzmann, Lotus Desbiolles, Sebastian Leschka, Hatem Alkadhi, Philipp A Kaufm...
Abstract P85: Out-of-hospital Cardiac Arrests With Extracorporeal Cardiopulmonary Resuscitation In Japan: Systematic Literature Review
Authors: Tetsuya Sakamoto, Yasufumi Asai, Ken Nagao, Yoshio Tahara, Takahiro Atsumi, Naoto Morimura, Satoshi Nara
Journal: Circulation (2008)

Background: In Japan, extracorporeal cardiopulmonary resuscitation (ECPR) became popular for cardiac arrest patients who resist conventional advanced life supports. Regardless of many clinical experiences, there has been no previous systematic literature review. Methods: Case series, reports and proceedings of scientific meeting about ECPR for out-of-hospital cardiac arrest written in Japanese between January 1, 1983 and July 31, 2007 were collected with Japana Centra Revuo Medicina (medical publication database in Japan) and review by experts. The outcome and characteristics of the patients were investigated, and the influence of publication bias of the case series study was also examined by the Funnel Plot method. Results: There were 951 out-of-hospital cardiac arrest patients who received ECPR in 92 reports (including 59 case series and 33 case reports) during the period. The average of age was 38.1 (4 – 88) years old and 76.1% was male. Three hundreds and eighty-one cases (40.1%) were arrests of cardiac etiology, and 212 were non-cardiac (22.3%). The cause of arrest was not described in other 37.6%. Excluding reports for only one case, weighted survival rate at discharge of 792 cases those were clearly described the outcome was 39.5±10.0%. When the relationship between the number of cases and the survival rate at discharge in each 59 case series study was shown in figure by the Funnel Plot method, the plotted data presented the reverse-funnel type that centered on the average of survival rate of all. Conclusions: The influence of publication bias of previous reports in Japan was relatively low. ECPR can greatly contribute to improve the outcome of out-of hospital cardiac arrests.
Simultaneous Transapical Implantation of an Inverted Transcatheter Aortic Valve-in-Ring in the Mitral Position and Transcatheter Aortic Valve Replacement
Authors: Ricardo Ladeiras-Lopes, Luís Vouga, Pedro Braga, Nélson Paulo, Ana Isabel Azevedo, Paulo Neves, José Ribeiro, Marlene Fonseca, Vasco Gama
Journal: Journal of the American College of Cardiology (2014)
Abortion: Between Freedom and Necessity
Authors: Janet Hadley
Journal: BMJ (1997)

Every day 150,000 pregnancies are terminated worldwide. Around 500 women, many of them young, lose their lives as a result of unsafe abortions. A quarter of the world's population live in countries where abortions are completely or almost completely prohibited. This book analyzes the international politics of abortion, the medical and social pressures and the impact of restricting or liberalizing abortion policies. It looks at questions such as: does abortion encourage teenage pregnancies?; does it harm a woman's physical or mental health?; how late should abortion be permitted?; and does a foetus have a right to life?
Cost of employing general practitioners in department may outweigh savings
Authors: D. P Burke, N. Rashid
Journal: BMJ (1995)

with splenomegaly but, unexpectedly, bone marrow fibrosis and hypocholesterolaemia (total cholesterol concentration 2-4 mmol/l, low density lipoprotein cholesterol concentration 1-5 mmol/l).It seems to us that the common denominator in low proliferating disorders with hypocholesterolaemia -that is, hairy cell leukaemia, myelofibrosis, and Gaucher's disease-is splenomegaly with an expanded reticuloendothelial system.Acute myeloid leukaemia, in contrast, is a disease of rapidly proliferating tumour cells, in which hypocholesterolaemia is associated with tumour cell burden and increased degradation by tumour cells mediated by low density lipoprotein receptors.
Peritoneoscopy
Authors: R. Herrera-Llerandi
Journal: BMJ (1961)

<h3>OBJECTIVE:</h3> A sensitive and accurate dot blot assay using recombinant p24 (gag), gp41 and gp120 (env) proteins of HIV-1 and also recombinant gp36, the specific HIV-2 antigen was developed to confirm the presence of antibodies in sera reactive in screening enzyme-linked immunosorbent assays. <h3>METHODS:</h3> We collected sera from Iranian 125 confirmed HIV positive Iranian samples (seropositive group) from AIDS patients, asymptomatic HIV-infected subjects, HIV-infected intravenous drug users and also hemophilic infected subjects. The samples were obtained from the AIDS Specimen Bank, Pasture Institute, Iran during 2002 to 2003. We also obtained 180 samples (seronegative group) from healthy blood donors. Recombinant antigens were expressed in Escherichia coli. By use of highly purified antigens, the dot blot procedure was developed. Analysis of the results was accomplished by capturing the dot blot images. <h3>RESULTS:</h3> We established and interpreted the results using Centers for Disease Control criteria. We defined the positive test result as the presence of antibody against at least 2 different HIV gene products, one of which had to be an env gene product while a negative test result was defined as no antibodies against any of the HIV gene products and an indeterminate result was defined as antibodies reacting with only one HIV env gene product or against gag gene product only. <h3>CONCLUSION:</h3> The recombinant HIV dot blotting assay identified seropositive individuals with a high degree of accuracy; none of the HIV-seropositive subjects had a negative test result. Reactivity with these antigens, demonstrated 100% sensitivity and specificity in distinguishing seronegative from seropositive sera. The different sets of Western blot interpretative accepted criteria did not make a difference in interpretation of the seronegative and seropositive samples.