tbuckley/cabot-search huggingface dataset:
Cost-Effectiveness of a Diabetes Self-Management Education and Support Intervention Led by Community Health Workers and Peer Leaders: Projections From the Racial and Ethnic Approaches to Community Health Detroit Trial
Authors: Wen Ye, Shihchen Kuo, Edith C. Kieffer, Gretchen Piatt, Brandy Sinco, Gloria Palmisano, Michael S. Spencer, William H. Herman
Journal: Diabetes Care (2020)

OBJECTIVE To simulate the long-term cost-effectiveness of a peer leader (PL)–led diabetes self-management support (DSMS) program following a structured community health worker (CHW)–led diabetes self-management education (DSME) program in reducing risks of complications in people with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS The trial randomized 222 Latino adults with T2D to 1) enhanced usual care (EUC); 2) a CHW-led, 6-month DSME program and 6 months of CHW-delivered monthly telephone outreach (CHW only); or 3) a CHW-led, 6-month DSME program and 12 months of PL-delivered weekly group sessions with telephone outreach to those unable to attend (CHW + PL). Empirical data from the trial and the validated Michigan Model for Diabetes were used to estimate cost and health outcomes over a 20-year time horizon from a health care sector perspective, discounting both costs and benefits at 3% annually. The primary outcome measure was the incremental cost-effectiveness ratio (ICER). RESULTS Over 20 years, the CHW + PL intervention had an ICER of $28,800 and $5,900 per quality-adjusted life-year (QALY) gained compared with the EUC and CHW-only interventions, respectively. The CHW-only intervention had an ICER of $430,600 per QALY gained compared with the EUC intervention. In sensitivity analyses, the results comparing the CHW + PL with EUC and CHW-only interventions were robust to changes in intervention effects and costs. CONCLUSIONS The CHW + PL–led DSME/DSMS intervention improved health and provided good value compared with the EUC intervention. The 6-month CHW-led DSME intervention without further postintervention CHW support was not cost effective in Latino adults with T2D.
Mycoplasma-induced Stevens-Johnson syndrome/toxic epidermal necrolysis: Case-control analysis of a cohort managed in a specialized center
Authors: Yasmin Chia Chia Liew, Karen Jui Lin Choo, Choon Chiat Oh, Shiu Ming Pang, Yi Wei Yeo, Haur Yueh Lee
Journal: Journal of the American Academy of Dermatology (2021)
Bimekizumab Offers Rapid and Durable Psoriasis Treatment
Authors: Anita Slomski
Journal: JAMA (2021)

Bimekizumab was highly effective for treating patients with moderate to severe plaque psoriasis in 2 phase 3 trials published in The Lancet. Bimekizumab is a novel, subcutaneously injected monoclonal IgG1 antibody that selectively inhibits interleukin 17F (IL-17F) in addition to IL-17A.
DOUBLE WHAMMY: A RARE PRESENTATION OF DUAL MECHANICAL COMPLICATIONS (VENTRICULAR SEPTAL RUPTURE AND MITRAL REGURGITATION) DUE TO THE DELAYED PRESENTATION OF INFERIOR STEMI
Authors: Jay Shah, Sachin Shah, Shiv Bagga, Paolo Mascari, David Venesy, Sourbha Dani, Gautam Gadey, Paul Pirundini, Arjun Majithia
Journal: Journal of the American College of Cardiology (2021)
Microglial lnc-U90926 facilitates neutrophil infiltration in ischemic stroke via MDH2/CXCL2 axis
Authors: Jian Chen, Jiali Jin, Xi Zhang, Hailong Yu, Xiaolei Zhu, Linjie Yu, Yanting Chen, Pinyi Liu, Xiaohong Dong, Xiang Cao, Yue Gu, Xinyu Bao, Shengnan Xia, Yun Xu
Journal: Molecular Therapy (2021)

Dysregulated long non-coding RNAs (lncRNAs) have been shown to contribute to the pathogenesis of ischemic stroke. However, the potential role of lncRNAs in post-stroke microglial activation remains largely unknown. Here, we uncovered that lncRNA-U90926 was significantly increased in microglia exposed to ischemia/reperfusion both in vivo and in vitro. In addition, adenovirus-associated virus (AAV)-mediated microglial U90926 silencing alleviated neurological deficits and reduced infarct volume in experimental stroke mice. Microglial U90926 knockdown could reduce the infiltration of neutrophils into ischemic lesion site, which might be attributed to the downregulation of C-X-C motif ligand 2 (CXCL2). Mechanistically, U90926 directly bound to malate dehydrogenase 2 (MDH2) and competitively inhibited the binding of MDH2 to the CXCL2 3' untranslated region (UTR), thus protecting against MDH2-mediated decay of CXCL2 mRNA. Taken together, our study demonstrated that microglial U90926 aggravated ischemic brain injury via facilitating neutrophil infiltration, suggesting that U90926 might be a potential biomarker and therapeutic target for ischemic stroke.
Suppressing the intestinal farnesoid X receptor/sphingomyelin phosphodiesterase 3 axis decreases atherosclerosis
Authors: Qing Wu, Lulu Sun, Xiaomin Hu, Xuemei Wang, Feng Xu, Bo Chen, Xianyi Liang, Jialin Xia, Pengcheng Wang, Daisuke Aibara, Shaofei Zhang, Guangyi Zeng, Chuyu Yun, Yu Yan, Yicheng Zhu, Michael Bustin, Shuyang Zhang, Frank J. Gonzalez, Changtao Jiang
Journal: Journal of Clinical Investigation (2021)

Intestinal farnesoid X receptor (FXR) signaling is involved in the development of obesity, fatty liver disease, and type 2 diabetes. However, the role of intestinal FXR in atherosclerosis and its potential as a target for clinical treatment have not been explored. The serum levels of fibroblast growth factor 19 (FGF19), which is encoded by an FXR target gene, were much higher in patients with hypercholesterolemia than in control subjects and were positively related to circulating ceramide levels, indicating a link between intestinal FXR, ceramide metabolism, and atherosclerosis. Among ApoE-/- mice fed a high-cholesterol diet (HCD), intestinal FXR deficiency (in FxrΔIE ApoE-/- mice) or direct FXR inhibition (via treatment with the FXR antagonist glycoursodeoxycholic acid [GUDCA]) decreased atherosclerosis and reduced the levels of circulating ceramides and cholesterol. Sphingomyelin phosphodiesterase 3 (SMPD3), which is involved in ceramide synthesis in the intestine, was identified as an FXR target gene. SMPD3 overexpression or C16:0 ceramide supplementation eliminated the improvements in atherosclerosis in FxrΔIE ApoE-/- mice. Administration of GUDCA or GW4869, an SMPD3 inhibitor, elicited therapeutic effects on established atherosclerosis in ApoE-/- mice by decreasing circulating ceramide levels. This study identified an intestinal FXR/SMPD3 axis that is a potential target for atherosclerosis therapy.
Diagnosis of Pseudoprogression Following Lomustine–Temozolomide Chemoradiation in Newly Diagnosed Glioblastoma Patients Using FET-PET
Authors: Jan-Michael Werner, Johannes Weller, Garry Ceccon, Christina Schaub, Caroline Tscherpel, Philipp Lohmann, Elena K. Bauer, Niklas Schäfer, Gabriele Stoffels, Christian Baues, Eren Celik, Simone Marnitz, Christoph Kabbasch, Gerrit H. Gielen, Gereon R. Fink, Karl-Josef Langen, Ulrich Herrlinger, Norbert Galldiks
Journal: Clinical Cancer Research (2021)

The CeTeG/NOA-09 phase III trial demonstrated a significant survival benefit of lomustine-temozolomide chemoradiation in patients with newly diagnosed glioblastoma with methylated O6-methylguanine-DNA methyltransferase (MGMT) promoter. Following lomustine-temozolomide chemoradiation, late and prolonged pseudoprogression may occur. We here evaluated the value of amino acid PET using O-(2-[18F]fluoroethyl)-l-tyrosine (FET) for differentiating pseudoprogression from tumor progression.We retrospectively identified patients (i) who were treated off-study according to the CeTeG/NOA-09 protocol, (ii) had equivocal MRI findings after radiotherapy, and (iii) underwent additional FET-PET imaging for diagnostic evaluation (number of scans, 1-3). Maximum and mean tumor-to-brain ratios (TBRmax, TBRmean) and dynamic FET uptake parameters (e.g., time-to-peak) were calculated. In patients with more than one FET-PET scan, relative changes of TBR values were evaluated, that is, an increase or decrease of >10% compared with the reference scan was considered as tumor progression or pseudoprogression. Diagnostic performances were evaluated using ROC curve analyses and Fisher exact test. Diagnoses were confirmed histologically or clinicoradiologically.We identified 23 patients with 32 FET-PET scans. Within 5-25 weeks after radiotherapy (median time, 9 weeks), pseudoprogression occurred in 11 patients (48%). The parameter TBRmean calculated from the FET-PET performed 10 ± 7 days after the equivocal MRI showed the highest accuracy (87%) to identify pseudoprogression (threshold, <1.95; P = 0.029). The integration of relative changes of TBRmean further improved the accuracy (91%; P < 0.001). Moreover, the combination of static and dynamic parameters increased the specificity to 100% (P = 0.005).The data suggest that FET-PET parameters are of significant clinical value to diagnose pseudoprogression related to lomustine-temozolomide chemoradiation.
Genomic stratification of myelodysplastic/myeloproliferative neoplasms, unclassifiable: Sorting through the unsorted
Authors: Abhishek A. Mangaonkar, David M. Swoboda, Terra L. Lasho, Christy Finke, Rhett P. Ketterling, Kaaren K. Reichard, Eric Padron, Chetasi Talati, Mrinal M. Patnaik
Journal: Leukemia (2021)
Abstract 416: Pluripotent Stem Cell Signaling in Pediatric Heart Failure Patients
Authors: Kathleen C Woulfe, Phillip Tatman, Anis Karimpour-Fard, Xuan Jiang, Karin Nunley, Shelley D Miyamoto, Brian L Stauffer, Carmen C Sucharov
Journal: Circulation Research (2016)

Pediatric heart failure is a heterogeneous disease process with congenital heart disease being the most common indication for heart transplantation in infants, and dilated cardiomyopathy (DCM) the most common indication in older children. Due to limitations of studying pediatric populations, there is no specific therapy for children with DCM. Importantly, the application of proven adult therapies to pediatric patients with DCM has resulted in no substantial improvement in survival over the past three decades. Therefore, there is a clear need for new approaches to better understand this disease process. In this study, we investigated global cardiac transcriptome and circulating serum proteome changes in pediatric patients with idiopathic dilated cardiomyopathy (IDC) and non-failing controls. Changes were identified in cytokine signaling, signal transduction, and transcription in pediatric IDC patients when compared to non-failing controls. Interestingly, these changes closely resemble the induction of stem cell pluripotency and signaling in resting stem cell populations. Importantly, the transcriptome changes are age-specific and were not observed in adult IDC patients. In addition, the protein profile in serum from pediatric IDC patients identified several factors related to inflammation, and treatment of cardiomyocyte-derived induced pluripotent stem cells (iPSC) with pediatric IDC serum recapitulated pathologic changes in gene expression, including expression of genes altered in the failing pediatric heart. These findings suggest that pathologic changes in cardiomyocytes may be triggered by circulating factors present in the serum resulting in pluripotent and stem cell signaling. These results provide several novel targets for future research and therapeutic intervention.
RIGHT VENTRICULAR HEART FAILURE SECONDARY TO SEVERE PULMONARY HYPERTENSION AFTER RUPTURED BREAST IMPLANTS
Authors: Amandeep Goyal, Maya Safarova, Tarun Dalia, Venugopal Brijmohan Bhattad, Sagar Ranka, Nadish Garg, Zubair Shah
Journal: Journal of the American College of Cardiology (2021)
Efficacy of NVX-CoV2373 Covid-19 Vaccine against the B.1.351 Variant
Authors: Vivek Shinde, Sutika Bhikha, Zaheer Hoosain, Moherndran Archary, Qasim Bhorat, Lee Fairlie, Umesh Lalloo, Mduduzi S.L. Masilela, Dhayendre Moodley, Sherika Hanley, Leon Fouche, Cheryl Louw, Michele Tameris, Nishanta Singh, Ameena Goga, Keertan Dheda, Coert Grobbelaar, Gertruida Kruger, Nazira Carrim-Ganey, Vicky Baillie, Tulio de Oliveira, Anthonet Lombard Koen, Johan J. Lombaard, Rosie Mngqibisa, As’ad E. Bhorat, Gabriella Benadé, Natasha Lalloo, Annah Pitsi, Pieter-Louis Vollgraaff, Angelique Luabeya, Aliasgar Esmail, Friedrich G. Petrick, Aylin Oommen-Jose, Sharne Foulkes, Khatija Ahmed, Asha Thombrayil, Lou Fries, Shane Cloney-Clark, Mingzhu Zhu, Chijioke Bennett, Gary Albert, Emmanuel Faust, Joyce S. Plested, Andreana Robertson, Susan Neal, Iksung Cho, Greg M. Glenn, Filip Dubovsky, Shabir A. Madhi
Journal: New England Journal of Medicine (2021)

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants threatens progress toward control of the coronavirus disease 2019 (Covid-19) pandemic. In a phase 1–2 trial involving healthy adults, the NVX-CoV2373 nanoparticle vaccine had an acceptable safety profile and was associated with strong neutralizing-antibody and antigen-specific polyfunctional CD4+ T-cell responses. Evaluation of vaccine efficacy was needed in a setting of ongoing SARS-CoV-2 transmission.
Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations
Authors: Silvia Affo, Ajay Nair, Francesco Brundu, Aashreya Ravichandra, Sonakshi Bhattacharjee, Michitaka Matsuda, LiKang Chin, Aveline Filliol, Wen Wen, Xinhua Song, Aubrianna Decker, Jeremy Worley, Jorge Matias Caviglia, Lexing Yu, Deqi Yin, Yoshinobu Saito, Thomas Savage, Rebecca G. Wells, Matthias Mack, Lars Zender, Nicholas Arpaia, Helen E. Remotti, Raul Rabadan, Peter Sims, Anne-Laure Leblond, Achim Weber, Marc-Oliver Riener, Brent R. Stockwell, Jellert Gaublomme, Josep M. Llovet, Raghu Kalluri, George K. Michalopoulos, Ekihiro Seki, Daniela Sia, Xin Chen, Andrea Califano, Robert F. Schwabe
Journal: Cancer Cell (2021)
RNA-Seq Revealed an Integration of Multiple Resistance Functions for Predicting Response to the 7+3 Induction Chemotherapy of De Novo Acute Myeloid Leukemia
Authors: Yu-Chiao Chiu, Tzu-Chieh Ho, Jia-Rong Tsai, Li-Ju Wang, Shih-Lan Hsu, Yidong Chen, Chieh-Lin Teng, Tzu-Hung Hsiao
Journal: Blood (2017)
SEX DIFFERENCES IN CARDIAC REMODELING IN RESPONSE TO ISCHEMIC MITRAL REGURGITATION PATIENTS WITH ADVANCED ISCHEMIC CARDIOMYOPATHY
Authors: Ramya Vajapey, Nancy Obuchowski, Zoran Popovic, Brian Griffin, WH Wilson Tang, Scott Flamm, Deborah Kwon
Journal: Journal of the American College of Cardiology (2021)
Nonsense-mediated RNA decay and its bipolar function in cancer
Authors: Gonçalo Nogueira, Rafael Fernandes, Juan F. García-Moreno, Luísa Romão
Journal: Molecular Cancer (2021)

Abstract Nonsense-mediated decay (NMD) was first described as a quality-control mechanism that targets and rapidly degrades aberrant mRNAs carrying premature termination codons (PTCs). However, it was found that NMD also degrades a significant number of normal transcripts, thus arising as a mechanism of gene expression regulation. Based on these important functions, NMD regulates several biological processes and is involved in the pathophysiology of a plethora of human genetic diseases, including cancer. The present review aims to discuss the paradoxical, pro- and anti-tumorigenic roles of NMD, and how cancer cells have exploited both functions to potentiate the disease. Considering recent genetic and bioinformatic studies, we also provide a comprehensive overview of the present knowledge of the advantages and disadvantages of different NMD modulation-based approaches in cancer therapy, reflecting on the challenges imposed by the complexity of this disease. Furthermore, we discuss significant advances in the recent years providing new perspectives on the implications of aberrant NMD-escaping frameshifted transcripts in personalized immunotherapy design and predictive biomarker optimization. A better understanding of how NMD differentially impacts tumor cells according to their own genetic identity will certainly allow for the application of novel and more effective personalized treatments in the near future.
TWO YEAR SAFETY AND EFFICACY OF CARDIAC NEUROMODULATION THERAPY IN HYPERTENSIVE PATIENTS INDICATED FOR A PACEMAKER
Authors: Zbigniew Kalarus, Merkely P. Bela, Petr Neuzil, Przemyslaw Mitkowski, Andrejs Erglis, Marcin Grawobski, Germanas Marinskis, Jaroslaw Kazmierczak, Slawomir Pluta, Laszlo Geller, Istvan Osztheimer, Filip Malek, Libor Dujka, Lidia Chmielewska-Michalak, Agnieska Kolodzinska, Ieva Anasberga, Jurate Barysiene, Diana Paskusdzka, Milosz Stepien, Adam Sokal
Journal: Journal of the American College of Cardiology (2021)
T-Cell Replete Peripheral Blood Haploidentical Transplant Using Immunogenic Dose of Cyclophosphamide with Fludarabine and Melphalan Results in Enhanced Cytokine Release Syndrome (CRS) with Robust Immune Recovery and Low Relapse Rates
Authors: Yasser Khaled, Jason C. Chandler, Joshua Boss, Arnel Pallera, Michael G. Martin, Robert Bradley, Robert Johnson
Journal: Blood (2017)
Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension
Authors: Tim Gruber, Chenchen Pan, Raian E. Contreras, Tobias Wiedemann, Donald A. Morgan, Alicja A. Skowronski, Sandrine Lefort, Cahuê De Bernardis Murat, Ophelia Le Thuc, Beata Legutko, Francisco J. Ruiz-Ojeda, María de la Fuente-Fernández, Angel Luis García-Villalón, Daniel González-Hedström, Melanie Huber, Klara Szigeti-Buck, Timo D. Müller, Siegfried Ussar, Paul Pfluger, Steve C. Woods, Ali Ertürk, Charles A. LeDuc, Kamal Rahmouni, Miriam Granado, Tamas L. Horvath, Matthias H. Tschöp, Cristina García-Cáceres
Journal: Cell Metabolism (2021)

Pathologies of the micro- and macrovascular systems are a hallmark of the metabolic syndrome, which can lead to chronically elevated blood pressure. However, the underlying pathomechanisms involved still need to be clarified. Here, we report that an obesity-associated increase in serum leptin triggers the select expansion of the micro-angioarchitecture in pre-autonomic brain centers that regulate hemodynamic homeostasis. By using a series of cell- and region-specific loss- and gain-of-function models, we show that this pathophysiological process depends on hypothalamic astroglial hypoxia-inducible factor 1α-vascular endothelial growth factor (HIF1α-VEGF) signaling downstream of leptin signaling. Importantly, several distinct models of HIF1α-VEGF pathway disruption in astrocytes are protected not only from obesity-induced hypothalamic angiopathy but also from sympathetic hyperactivity or arterial hypertension. These results suggest that hyperleptinemia promotes obesity-induced hypertension via a HIF1α-VEGF signaling cascade in hypothalamic astrocytes while establishing a novel mechanistic link that connects hypothalamic micro-angioarchitecture with control over systemic blood pressure.
Predicting anti-PD-1 responders in malignant melanoma from the frequency of S100A9+ monocytes in the blood
Authors: Soudabeh Rad Pour, Yago Pico de Coaña, Xavier Martinez Demorentin, Jeroen Melief, Manjula Thimma, Maria Wolodarski, David Gomez-Cabrero, Johan Hansson, Rolf Kiessling, Jesper Tegner
Journal: Journal for ImmunoTherapy of Cancer (2021)

While programmed cell death receptor 1 (PD-1) blockade treatment has revolutionized treatment of patients with melanoma, clinical outcomes are highly variable, and only a fraction of patients show durable responses. Therefore, there is a clear need for predictive biomarkers to select patients who will benefit from the treatment.To identify potential predictive markers for response to PD-1 checkpoint blockade immunotherapy, we conducted single-cell RNA sequencing analyses of peripheral blood mononuclear cells (PBMC) (n=8), as well as an in-depth immune monitoring study (n=20) by flow cytometry in patients with advanced melanoma undergoing treatment with nivolumab at Karolinska University Hospital. Blood samples were collected before the start of treatment and at the time of the second dose.Unbiased single-cell RNA sequencing of PBMC in patients with melanoma uncovered that a higher frequency of monocytes and a lower ratio of CD4+ T cells to monocyte were inversely associated with overall survival. Similarly, S100A9 expression in the monocytic subset was correlated inversely with overall survival. These results were confirmed by a flow cytometry-based analysis in an independent patient cohort.Our results suggest that monocytic cell populations can critically determine the outcome of PD-1 blockade, particularly the subset expressing S100A9, which should be further explored as a possible predictive biomarker. Detailed knowledge of the biological role of S100A9+ monocytes is of high translational relevance.
Abstract 13588: Clinical Outcomes of Remote Magnetic Navigation Ablation of Papillary Muscle Versus Right Ventricular Outflow Tract Premature Ventricular Contractions
Authors: Neil Beri, Xin Zhang, Pankaj Malhotra, Dali Fan, Nayereh Pezeshkian, Uma Srivatsa
Journal: Circulation (2019)

Introduction: Remote magnetic navigation (RMN) is sometimes used in conjunction with a mapping system for ablation of arrhythmias including premature ventricular contractions (PVCs). Published data...
EPIGENETIC BET READER INHIBITOR APABETALONE (RVX-208) COUNTERS PROINFLAMMATORY AORTIC GENE EXPRESSION IN A DIET INDUCED OBESITY MOUSE MODEL
Authors: Sylwia Wasiak, Emily Daze, Laura Tsujikawa, Dean Gilham, Christopher Sarsons, Stephanie Stotz, Brooke Rakai, Salman Azhar, Ravi Jahargirdar, Michael Sweeney, Jan Johansson, Norman Wong, Ewelina Kulikowski
Journal: Journal of the American College of Cardiology (2021)
Endoscopic resection of a complex gastric duplication cyst using a submucosal tunneling technique
Authors: Radhika Chavan, Zaheer Nabi, Jahangeer Basha, Anuradha Sekaran, Santosh Darisetty, Palle Manohar Reddy, D. Nageshwar Reddy
Journal: Endoscopy (2021)

A 48-year-old woman was incidentally found to have a submucosal lesion (~3 cm) in the antrum, while being evaluated for dyspeptic symptoms ([Fig. 1]). Imaging including endoscopic ultrasound and computed tomography suggested a cystic lesion in the antrum ([Fig. 2]).
CHANGES IN COMPUTED-TOMOGRAPHY DERIVED SEGMENTAL LEFT VENTRICULAR LONGITUDINAL STRAIN AFTER TRANSCATHETER AORTIC VALVE IMPLANTATION
Authors: Gurpreet Singh, Federico Fortuni, Jurrien H. Kuneman, Elise M. Vollema, Frank van der Kley, Nina Ajmone Marsan, Victoria Delgado, Jeroen Bax
Journal: Journal of the American College of Cardiology (2021)
IMPACT OF UPPER GASTROINTESTINAL HEMORRHAGE ON ADULT PATIENTS ADMITTED WITH ACUTE CORONARY SYNDROME (FROM THE NATIONAL INPATIENT SAMPLE 2016-2017)
Authors: Dimeji Williams, Iriagbonse Asemota, Emmanuel Akuna, Raquel Soon-Shiong, Cyra Kang, Muhammad Usman Almani, Muhammad Usman, Mahmoud Elbermawy, Smriti Khanal, Bharosa Sharma, Ibrahim Maghari
Journal: Journal of the American College of Cardiology (2021)
REAL-WORLD HOSPITALIZATION RATES AND ASSOCIATED FACTORS BETWEEN ATRIAL FIBRILLATION PATIENTS TREATED WITH AND WITHOUT CATHETER ABLATION
Authors: Zhaojie Dong, Xin Du, Chao Jiang, Shijun Xia, Liu He, Jianzeng Dong, Bojing Cai, Changsheng Ma
Journal: Journal of the American College of Cardiology (2021)
EVALUATION OF DISCORDANCES BETWEEN FRACTIONAL FLOW RESERVE AND RESTING FULL-CYCLE RATIO IN INTERMEDIATE CORONARY ARTERY STENOSIS
Authors: Xiaomeng Deng, Joshua Rezkalla, Aditya Goud, Pooya Bokhoor, Rushi Parikh, Olcay Aksoy, Marcella Calfon-Press, Ravi Dave, Asim Rafique
Journal: Journal of the American College of Cardiology (2021)
IMPROVEMENT OF THE 10-YEAR ATHEROSCLEROTIC CARDIOVASCULAR DISEASE RISK WITH ONCE-WEEKLY SEMAGLUTIDE 2.4 MG IN ADULTS WITH OVERWEIGHT OR OBESITY - POST-HOC ANALYSIS OF THE STEP 1 TRIAL
Authors: Subodh Verma, Meena Bhatta, Melanie Davies, John Deanfield, Tim Garvey, Robert Kushner, Domenica M. Rubino, Usman Khalid, Niels Zeuthen, Mikhail Kosiborod
Journal: Journal of the American College of Cardiology (2021)