tbuckley/cabot-search huggingface dataset:
Abstract 14229: Northern New England’S Multicenter Experience With Percutaneous Coronary Intervention Among Patients With Coronary Artery Disease Undergoing Transcatheter Aortic Valve Replacement
Authors: Jay Shah, Jessica Kvasic, Paul Frey, David Butzel, Michael P Robich, Reed Quinn, John Jayne, David J Malenka, Samip Vasaiwala
Journal: Circulation (2019)

Introduction and Background: The incidence of coronary artery disease in patients undergoing transcatheter aortic valve replacement (TAVR) averages nearly 70%. According to current guidelines, coro...
Brentuximab Vedotin Combined With Chemotherapy in Patients With Newly Diagnosed Early-Stage, Unfavorable-Risk Hodgkin Lymphoma
Authors: Anita Kumar, Carla Casulo, Ranjana H. Advani, Elizabeth Budde, Paul M. Barr, Connie L. Batlevi, Philip Caron, Louis S. Constine, Savita V. Dandapani, Esther Drill, Pamela Drullinsky, Jonathan W. Friedberg, Clare Grieve, Audrey Hamilton, Paul A. Hamlin, Richard T. Hoppe, Steven M. Horwitz, Ashlee Joseph, Niloufer Khan, Leana Laraque, Matthew J. Matasar, Alison J. Moskowitz, Ariela Noy, Maria Lia Palomba, Heiko Schöder, David J. Straus, Shreya Vemuri, Joanna Yang, Anas Younes, Andrew D. Zelenetz, Joachim Yahalom, Craig H. Moskowitz
Journal: Journal of Clinical Oncology (2021)

To improve curability and limit long-term adverse effects for newly diagnosed early-stage (ES), unfavorable-risk Hodgkin lymphoma.In this multicenter study with four sequential cohorts, patients received four cycles of brentuximab vedotin (BV) and doxorubicin, vinblastine, and dacarbazine (AVD). If positron emission tomography (PET)-4-negative, patients received 30-Gy involved-site radiotherapy in cohort 1, 20-Gy involved-site radiotherapy in cohort 2, 30-Gy consolidation-volume radiotherapy in cohort 3, and no radiotherapy in cohort 4. Eligible patients had ES, unfavorable-risk disease. Bulk disease defined by Memorial Sloan Kettering criteria (> 7 cm in maximal transverse or coronal diameter on computed tomography) was not required for cohorts 1 and 2 but was for cohorts 3 and 4. The primary end point was to evaluate safety for cohort 1 and to evaluate complete response rate by PET for cohorts 2-4.Of the 117 patients enrolled, 116 completed chemotherapy, with the median age of 32 years: 50% men, 98% stage II, 86% Memorial Sloan Kettering-defined disease bulk, 27% traditional bulk (> 10 cm), 52% elevated erythrocyte sedimentation rate, 21% extranodal involvement, and 56% > 2 involved lymph node sites. The complete response rate in cohorts 1-4 was 93%, 100%, 93%, and 97%, respectively. With median follow-up of 3.8 years (5.9, 4.5, 2.5, and 2.2 years for cohorts 1-4), the overall 2-year progression-free and overall survival were 94% and 99%, respectively. In cohorts 1-4, the 2-year progression-free survival was 93%, 97%, 90%, and 97%, respectively. Adverse events included neutropenia (44%), febrile neutropenia (8%), and peripheral neuropathy (54%), which was largely reversible.BV + AVD × four cycles is a highly active and well-tolerated treatment program for ES, unfavorable-risk Hodgkin lymphoma, including bulky disease. The efficacy of BV + AVD supports the safe reduction or elimination of consolidative radiation among PET-4-negative patients.
MINOCA AT ITS WORST: IMPLANTABLE CARDIAC DEFIBRILLATOR AS A LIFE SAVING DEVICE IN A RARE CASE OF VASOSPASTIC ANGINA
Authors: Anil Kumar Jonnalagadda, Aadhar Patil, Philip Lavenburg, Brian O'Murchu, Edmond Cronin, Michael Gannon
Journal: Journal of the American College of Cardiology (2021)
SAFETY AND EFFICACY OF SOLUBLE GUANYLATE CYCLASE STIMULATORS IN PATIENTS WITH HEART FAILURE
Authors: Mohamed Zghouzi, Waqas Ullah, Bachar Ahmad, Yasar Sattar, Nathan Zaher, Tanveer Mir, Nada Elmakshbr, Omar Ali, Delair Gardi, Zaher Hakim, M. Chadi Alraies
Journal: Journal of the American College of Cardiology (2021)
Deconditioning as main mechanism of impaired exercise response in COVID-19 survivors
Authors: Rocco Francesco Rinaldo, Michele Mondoni, Elena Maria Parazzini, Federica Pitari, Elena Brambilla, Simone Luraschi, Maurizio Balbi, Giuseppe Francesco Sferrazza Papa, Giovanni Sotgiu, Marco Guazzi, Fabiano Di Marco, Stefano Centanni
Journal: European Respiratory Journal (2021)

<b>CPET reveals only a mild impairment of exercise capacity, with preserved ventilatory and gas exchange response at 3 months follow-up in COVID-19 survivors, due to deconditioning</b>https://bit.ly/3sI8e0Y
ASSESSING THE PERFORMANCE OF MACHINE LEARNING MODELS IN PREDICTING MORTALITY OF PATIENTS WITH CONNECTIVE TISSUE DISEASES UNDERGOING TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Mohamed M. Gad, Toshiaki Isogai, Anas Saad, Agam Bansal, Devora Lichtman, Shashank Shekhar, Abdelrahman Abushouk, Serge Harb, Samir Kapadia, Venu Menon, Heba Wassif
Journal: Journal of the American College of Cardiology (2021)
MACHINE LEARNING TO IDENTIFY HIGH-RISK PATIENTS AFTER STEMI IN LOW/MIDDLE INCOME COUNTRIES
Authors: Mohit Dayal Gupta, Manu Kumar Shetty, Girish MP, Sameer Arora, Arman Qamar, Muthiah Vaduganathan, Michael Hendrickson, Puneet Gupta, Ankit Bansal, Vardhmaan Jain, Vishal Batra, Saibal Mukhopadhyay, Jamal Yusuf, Sanjay Tyagi, Ranjitha Prasad, Anubha Gupta, Bhushan Shah, Prattay Sarkar, Deepak Bhatt
Journal: Journal of the American College of Cardiology (2021)
High Prevalence of Depressive Symptoms in Patients With Type 1 and Type 2 Diabetes in Developing Countries: Results From the International Diabetes Management Practices Study
Authors: Pablo Aschner, Juan José Gagliardino, Hasan Ilkova, Fernando Lavalle, Ambady Ramachandran, Jean Claude Mbanya, Marina Shestakova, Yann Bourhis, Jean-Marc Chantelot, Juliana C.N. Chan
Journal: Diabetes Care (2020)

OBJECTIVE Depression is common in people with diabetes, but data from developing countries are scarce. We evaluated the prevalence and risk factors for depressive symptoms in patients with diabetes using data from the International Diabetes Management Practices Study (IDMPS). RESEARCH DESIGN AND METHODS IDMPS is an ongoing multinational, cross-sectional study investigating quality of care in patients with diabetes in real-world settings. Data from wave 5 (2011), including 21 countries, were analyzed using the 9-item Patient Health Questionnaire (PHQ-9) to evaluate depressive symptoms. Logistic regression analyses were conducted to identify risk factors of depressive symptoms. RESULTS Of 9,865 patients eligible for analysis, 2,280 had type 1 and 7,585 had type 2 diabetes (treatment: oral glucose-lowering drugs [OGLD] only, n = 4,729; OGLDs plus insulin, n = 1,892; insulin only, n = 964). Depressive symptoms (PHQ-9 score ≥5) were reported in 30.7% of those with type 1 diabetes. In patients with type 2 diabetes, the respective figures were 29.0% for OGLDs-only, 36.6% for OGLDs-plus-insulin, and 46.7% for insulin-only subgroups. Moderate depressive symptoms (PHQ-9 score 10–19) were observed in 8–16% of patients with type 1 or type 2 diabetes. Female sex, complications, and low socioeconomic status were independently associated with depressive symptoms. In type 1 diabetes and in the type 2 diabetes OGLDs-only group, depression was associated with poor glycemic control. CONCLUSIONS Depressive symptoms are common in patients with diabetes from developing countries, calling for routine screening, especially in high-risk groups, to reduce the double burden of diabetes and depression and their negative interaction.
Between inflammation and thrombosis: endothelial cells in COVID-19
Authors: Anna Birnhuber, Elisabeth Fließer, Gregor Gorkiewicz, Martin Zacharias, Benjamin Seeliger, Sascha David, Tobias Welte, Julius Schmidt, Horst Olschewski, Malgorzata Wygrecka, Grazyna Kwapiszewska
Journal: European Respiratory Journal (2021)

<b>Elevated levels of several endothelial markers, including CD31, VEGFR-2, ICAM-1, VCAM-1, E-selectin, P-selectin and vWF, in lung tissue and circulation support an important role of the pulmonary endothelium in local and systemic COVID-19 pathology</b>https://bit.ly/3eQObIR
Deficiency of myeloid PHD proteins aggravates atherogenesis via macrophage apoptosis and paracrine fibrotic signalling
Authors: Kim van Kuijk, Jasper A F Demandt, Javier Perales-Patón, Thomas L Theelen, Christoph Kuppe, Elke Marsch, Jenny de Bruijn, Han Jin, Marion J Gijbels, Ljubica Matic, Barend M E Mees, Chris P M Reutelingsperger, Ulf Hedin, Erik A L Biessen, Peter Carmeliet, Andrew H Baker, Rafael K Kramann, Leon J Schurgers, Julio Saez-Rodriguez, Judith C Sluimer
Journal: Cardiovascular Research (2021)

Atherosclerotic plaque hypoxia is detrimental for macrophage function. Prolyl hydroxylases (PHDs) initiate cellular hypoxic responses, possibly influencing macrophage function in plaque hypoxia. Thus, we aimed to elucidate the role of myeloid PHDs in atherosclerosis.Myeloid-specific PHD knockout (PHDko) mice were obtained via bone marrow transplantation (PHD1ko, PHD3ko) or conditional knockdown through lysozyme M-driven Cre recombinase (PHD2cko). Mice were fed high cholesterol diet for 6-12 weeks to induce atherosclerosis. Aortic root plaque size was significantly augmented 2.6-fold in PHD2cko, and 1.4-fold in PHD3ko compared to controls but was unchanged in PHD1ko mice. Macrophage apoptosis was promoted in PHD2cko and PHD3ko mice in vitro and in vivo, via the hypoxia-inducible factor (HIF) 1α/BNIP3 axis. Bulk and single-cell RNA data of PHD2cko bone marrow-derived macrophages (BMDMs) and plaque macrophages, respectively, showed enhanced HIF1α/BNIP3 signalling, which was validated in vitro by siRNA silencing. Human plaque BNIP3 mRNA was positively associated with plaque necrotic core size, suggesting similar pro-apoptotic effects in human. Furthermore, PHD2cko plaques displayed enhanced fibrosis, while macrophage collagen breakdown by matrix metalloproteinases, collagen production, and proliferation were unaltered. Instead, PHD2cko BMDMs enhanced fibroblast collagen secretion in a paracrine manner. In silico analysis of macrophage-fibroblast communication predicted SPP1 (osteopontin) signalling as regulator, which was corroborated by enhanced plaque SPP1 protein in vivo. Increased SPP1 mRNA expression upon PHD2cko was preferentially observed in foamy plaque macrophages expressing 'triggering receptor expressed on myeloid cells-2' (TREM2hi) evidenced by single-cell RNA, but not in neutrophils. This confirmed enhanced fibrotic signalling by PHD2cko macrophages to fibroblasts, in vitro as well as in vivo.Myeloid PHD2cko and PHD3ko enhanced atherosclerotic plaque growth and macrophage apoptosis, while PHD2cko macrophages further activated collagen secretion by fibroblasts in vitro, likely via paracrine SPP1 signalling through TREM2hi macrophages.
Ethicists’ Deception: Theory, Role, Concepts, and Applications
Authors: Christopher Meyers
Journal: The American Journal of Bioethics (2021)

This article refers to:Deception and the Clinical EthicistLies of Omission and Commission, Providing and Withholding Treatment, Local and Global Autonomy – There Are Reasons for Clinical Ethicists to Attend to All of These DistinctionsWhy Truthfulness is the First of the VirtuesTrust, Transparency, and Trauma Informed CareDeceptive Omissions, Half-Truths, and the Moral Exemplar in Clinical EthicsHare's Archangel, Human Fallibility, and Utilitarian Justification(?) of DeceptionWhen First We Practice to DeceiveLies, Damned Lies, and BioethicistsShould the Clinical Ethicist Document Her Complicity in Intentional Deception?
Drug Release from Thermo‐Responsive Polymer Brush Coatings to Control Bacterial Colonization and Biofilm Growth on Titanium Implants
Authors: Hongsuh Choi, Anna Schulte, Mareike Müller, Mineon Park, Suenghwan Jo, Holger Schönherr
Journal: Advanced Healthcare Materials (2021)

Abstract Despite decades of biomedical advances, the colonization of implant devices with bacterial biofilms is still a leading cause of implant failure. Clearly, new strategies and materials that suppress both initial and later stage bacterial colonization are required in this context. Ideal would be the implementation of a bactericidal functionality in the implants that is temporally and spatially triggered in an autonomous fashion at the infection site. Herein, the fabrication and validation of functional titanium‐based implants with triggered antibiotic release function afforded via an intelligent polymer coating is reported. In particular, thermo‐responsive poly(di(ethylene glycol) methyl ether methacrylate) (PDEGMA) brushes on titanium implants synthesized via a surface‐initiated atom transfer radical polymerization with activators regenerated through the electron transfer technique (ARGET ATRP) allows for a controlled and thermally triggered release of the antibiotic levofloxacin at the wound site. Antibiotic loaded brushes are investigated as a function of thickness, loading capacity for antibiotics, and temperature. At temperatures of the infection site &gt;37 °C the lower critical solution temperature behavior of the brushes afforded the triggered release. Hence, in addition to the known antifouling effects, the PDEGMA coating ensured enhanced bactericidal effects, as demonstrated in initial in vivo tests with rodents infected with Staphylococcus aureus .
PRE-EXISTING CARDIOVASCULAR DISEASE, ACUTE KIDNEY INJURY, AND CARDIOVASCULAR OUTCOMES IN HOSPITALIZED BLACKS WITH COVID-19 INFECTION
Authors: Obiora Egbuche, Opeyemi Jegede, Temidayo Abe, Bivek Wagle, Ky Huynh, Dolphurs Hayes, Martin-Luther Campbell, Kenechukwu Mezue, Pradhum Ram, Rupak Desai, Jacques Kpodonu, Jayne Morgan, Elizabeth Ofili, Anekwe Onwuanyi, Melvin Echols
Journal: Journal of the American College of Cardiology (2021)
Morphological Characteristics of In-stent Restenosis Lesions after Percutaneous Coronary Intervention for Chronic Total Occlusive Lesions Assessed with Optical Coherence Tomography
Authors: Tada Takeshi, Kadota Kazushige, Kanazawa Takenori, Ichinohe Tahei, Kubo Shunsuke, Hyodo Yusuke, Miyake Koshi, Eguchi Haruki, Kawase Yuichi, Hayakawa Yuki, Ohtsuru Suguru, Hasegawa Daiji, Habara Seiji, Tanaka Hiroyuki, Maruo Takeshi, Fuku Yasushi, Katoh Harumi, Fujii Satoki, Gotoh Tsuyoshi, Mitsudo Kazuaki
Journal: Circulation (2014)
The Emerging Role of B Cells in the Pathogenesis of NAFLD
Authors: Fanta Barrow, Saad Khan, Haiguang Wang, Xavier S. Revelo
Journal: Hepatology (2021)

NAFLD is one of the leading causes of abnormal liver function worldwide. NAFLD refers to a group of liver conditions ranging from nonalcoholic fatty liver to NASH, which involves inflammation, hepatocellular damage, and fibrosis. Triggering of inflammation in NASH is a key event in the progression of the disease, and identifying the factors that initiate or dysregulate this process is needed to develop strategies for its prevention or treatment. B cells have been implicated in several autoimmune and inflammatory diseases. However, their role in the pathogenesis of NAFLD and NASH is less clear. This review discusses the emerging evidence implicating intrahepatic B cells in the progression of NAFLD. We highlight the potential mechanisms of B-cell activation during NAFLD, such as increased hepatic expression of B-cell-activating factor, augmented oxidative stress, and translocation of gut-derived microbial products. We discuss the possible effector functions by which B cells promote NAFLD, including the production of proinflammatory cytokines and regulation of intrahepatic T cells and macrophages. Finally, we highlight the role of regulatory and IgA+ B cells in the pathogenesis of NASH-associated HCC. In this review, we make the case that future research is needed to investigate the potential of B-cell-targeting strategies for the treatment of NAFLD.
SARS-CoV-2 vaccination in rituximab-treated patients: evidence for impaired humoral but inducible cellular immune response
Authors: Michael Markus Bonelli, Daniel Mrak, Thomas Perkmann, Helmuth Haslacher, Daniel Aletaha
Journal: Annals of the Rheumatic Diseases (2021)

This study aimed to evaluate timeliness of an outpatient urgent access neurovascular clinic in a district general hospital setting through an audit of delay from event to completion of evaluation following transient ischaemic attack (TIA) or minor stroke. Participants included those referred for evaluation of suspected TIA or minor stroke. The median delay from event to completion was 16 days, with 45% seen within two weeks of symptom onset, and 15% within one week of symptom onset. A weekly TIA clinic is not capable of achieving the National Clinical Guidelines for Stroke recommendation for evaluation within one week of symptoms. This audit supports the National Stroke Strategy recommendation for immediate evaluation of patients presenting with a recent TIA or minor stroke.
Publisher Correction: Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation
Authors: Jui-Hsia Weng, Peter David Koch, Harding H. Luan, Ho-Chou Tu, Kenichi Shimada, Iris Ngan, Richard Ventura, Ruomu Jiang, Timothy J. Mitchison
Journal: Nature Metabolism (2021)
PREVALENCE OF MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE AMONG PATIENTS HOSPITALIZED FOR MYOCARDIAL INFARCTION: INSIGHTS FROM THE NATIONAL INPATIENT SAMPLE 2016-2017
Authors: Daniel Antwi-Amoabeng, Jasmine Ghuman, Neha Agrawal, Joban Ghuman, Mark B. Ulanja, Bryce D. Beutler, Rajeshwari Ayyar
Journal: Journal of the American College of Cardiology (2021)
ARID5B Activates the TAL1-Induced Core Regulatory Circuit and the MYC Oncogene in T-Cell Acute Lymphoblastic Leukemia
Authors: Wei Zhong Leong, Shi Hao Tan, Phuong Cao Thi Ngoc, Stella Amanda, Alice Wei Yee Yam, Wei-Siang Liau, Zhiyuan Gong, Lee N. Lawton, Daniel G. Tenen, Takaomi Sanda
Journal: Blood (2017)
GENDER-RELATED DIFFERENCES IN HYPERTROPHIC CARDIOMYOPATHY: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Angkawipa Trongtorsak, Natchaya Polpichai, Sittinun Thangjui, Jakrin Kewcharoen, Ratdanai Yodsuwan, Amrit Devkota, Harvey J. Friedman, Alfonso Estrada
Journal: Journal of the American College of Cardiology (2021)
Progress with Treatments for Alzheimer’s Disease
Authors: Allan I. Levey
Journal: New England Journal of Medicine (2021)

An estimated 50 million people worldwide have dementia, mostly due to Alzheimer's disease. The inexorable progression of Alzheimer's disease exerts a huge toll on patients, families, and society, costing approximately $1 trillion annually, an amount that is likely to increase with the growing number of elderly people. It is no surprise that Alzheimer's disease is among the most feared diseases of aging. Hence, there is widespread interest as new clinical trial results are reported, but also much angst given all the trial failures to date. This issue of the Journal provides some tentative hope with the results of TRAILBLAZER-ALZ, a . . .
IMPACT OF RIGHT HEART CATHETERIZATION IN ACUTE HEART FAILURE WITH REDUCED EJECTION FRACTION
Authors: Samarthkumar Thakkar, Harsh Patel, Kirtenkumar Patel, Ashish Kumar, Smit Patel, Bryan E-Xin Tan, Kirolos Barssoum, Chinmay Jani, Toralben Patel, Marmik Patel, Tanushri Bhushan, Devina Adalja, Vishal Parikh, Scott Feitell
Journal: Journal of the American College of Cardiology (2021)
DIALYSIS INITIATION IN PATIENTS WITH STABLE ISCHEMIC HEART DISEASE AND SEVERE CHRONIC KIDNEY DISEASE IN THE ISCHEMIA-CKD TRIAL
Authors: Carlo Briguori, Kreton Mavromatis, Zhen Huang, Roy Mathew, Latonya Hickson, Wei Ling Lau, Zhiming Ye, Anoop Mathew, Sandeep Mahajan, David Wheeler, Kathleen Claes, Galen Chen, Fernando Nolasco, Jerome Fleg, Mandeep Sidhu, Glenn Chertow, Judith Hochman, David Maron, Sripal Bangalore
Journal: Journal of the American College of Cardiology (2021)
Toward a computational theory of social groups: A finite set of cognitive primitives for representing any and all social groups in the context of conflict
Authors: David Pietraszewski
Journal: Behavioral and Brain Sciences (2021)

We don't yet have adequate theories of what the human mind is representing when it represents a social group. Worse still, many people think we do. This mistaken belief is a consequence of the state of play: Until now, researchers have relied on their own intuitions to link up the concept social group on the one hand and the results of particular studies or models on the other. While necessary, this reliance on intuition has been purchased at a considerable cost. When looked at soberly, existing theories of social groups are either (i) literal, but not remotely adequate (such as models built atop economic games), or (ii) simply metaphorical (typically a subsumption or containment metaphor). Intuition is filling in the gaps of an explicit theory. This paper presents a computational theory of what, literally, a group representation is in the context of conflict: It is the assignment of agents to specific roles within a small number of triadic interaction types. This "mental definition" of a group paves the way for a computational theory of social groups - in that it provides a theory of what exactly the information-processing problem of representing and reasoning about a group is. For psychologists, this paper offers a different way to conceptualize and study groups, and suggests that a non-tautological definition of a social group is possible. For cognitive scientists, this paper provides a computational benchmark against which natural and artificial intelligences can be held.
Abstract 17056: Food and Drug Administration Mandated Post-Market Studies for High Risk Cardiovascular Devices Approved 2015-2019
Authors: Danelle Hidano, Sanket Dhruva, Rita F Redberg
Journal: Circulation (2020)

Introduction: The Food and Drug Administration (FDA) emphasizes a “life-cycle approach” to medical device regulation, in which the pre-approval process is expedited and more emphasis is placed on post-approval data in order to shorten patient access to new devices. The FDA can mandate post approval studies (PASs) for high-risk devices to augment pre-approval data. This study describes the characteristics of FDA-mandated PASs. Methods: We searched the FDA database for all PASs required for original high-risk cardiovascular devices approved from January 1, 2015 and December 31, 2019. Data elements abstracted for each PAS included: study type, presence of controls, blinding, total number of patients enrolled, study duration, and whether primary outcomes were surrogate or composite measures. We also checked the FDA website for any available interim data prior to study completion. Results: The FDA approved 71 high-risk cardiovascular devices and ordered a total of 68 PASs for 49 (69%) devices. Most PASs were prospective cohorts (n=47, 69.1%). The median study size was 250 patients (IQR 151-563) and median study duration was 5 years (IQR 3-5). Only 19 studies (28%) included active or historic controls, 12 studies (17.7%) were randomized, 5 studies (7.3%) were single-blinded, and none were double-blinded (Table). Twenty-two (32.4%) studies provided data before completion of study. Conclusion: Most PAS are not randomized, lack controls, contain small numbers of patients, and have composite or surrogate primary outcomes that may not be clinically relevant, despite their importance for generating long-term clinical data for high-risk cardiovascular devices. Interim data are often not available. Increased quality and availability of evidence related to PASs would better establish device safety, effectiveness, and appropriate use. Lastly, PAS data should be readily accessible to help clinicians and patients make well-informed decisions.
Antony Graham Davies
Authors: William A M Cutting, Stephen Rigden-Green
Journal: BMJ (2021)

Antony Graham Davies (“Tony”), a committed Quaker Christian, refused military conscription but accepted a post with the British Antarctic Survey in 1959-62. His work on the physiology of the men in the team was accepted with high commendation as an MD thesis in 1963. He worked in Birmingham at the Women’s Hospital and the university from 1968 to 1983 as lecturer and on endocrine research. He was awarded PhD in 1976. He was a competent violinist and played regularly in an orchestra in the Midlands Art Centre.

He was professor of physiology at Juba Medical College, South Sudan, in 1984-1986. From 1989 to 1991 he was field project leader for …