tbuckley/cabot-search huggingface dataset:
Prevalence of and Factors Associated With Substance Use Among Canadian Medical Students
Authors: Anees Bahji, Marlon Danilewitz, Eva Guerin, Brandon Maser, Erica Frank
Journal: JAMA Network Open (2021)

95% CI, 1.44-1.91; current cigarette use: OR, 2.31; 95% CI, 1.71-3.11; cannabis in past 12 months: OR, 1.41; 95% CI, 1.19-1.69;NPS in past 12 months: OR, 1.72; 95% CI, 1.22-2.42).Lower age was associated with self-reported cannabis use in the past 12 months (OR, 0.95; 95% CI, 0.93-0.97)and excessive alcohol use (OR, 0.96; 95% CI, 0.94-0.98),whereas older students were more likely to self-report cigarette use (OR, 1.17; 95% CI, 1.14-1.21)(Table 2).There was no significant association between self-reported substance use and mood or anxiety disorders.However, students with higher psychological distress were more likely to report excessive
Abstract 9007: Higher Level of Chronic Illness Management is Associated With Greater Trust in the Heart Transplant Team
Authors: Mia Cajita, Juliane Mielke, Kris Denhaerynck, Fabienne Dobbels, Cynthia Russell, Sabina M De Geest
Journal: Circulation (2021)

Trust is associated with better patient outcomes, such as better medication adherence and improved patient satisfaction. However, the association between trust and level of chronic illness management (CIM) has not yet been addressed. We assessed the hypothesis that level of CIM will be associated with trust in the HTx team. Additionally, we explored potential meso-level moderators of this relationship (time spent on patient visits, number of visits, multidisciplinarity, CIM competencies, and CIM preparedness of the healthcare team). A secondary analysis was conducted using the international cross-sectional BRIGHT study, which included 1397 HTx recipients and 100 HTx clinicians from 36 HTx centers across 11 countries. Level of CIM was measured using the Patient Assessment of Chronic Illness Care (PACIC – patients’ report) and the CIMI BRIGHT (clinicians’ reports). Patients’ trust in the HTx team was measured using an adapted Wake Forest Trust scale. Multiple logistic regression was used to test the hypothesis. 1397 patients (mean age 53.6 13.2 years; 72.7% male; 85.9% white; average time post HTx 3.4 1.4 years) and 100 HTx clinicians (mean age 46.2 10.2 years; 87% female; 85% nurses; mean time worked in HTx center 10.0 7.5 years) were included. Even after controlling for patient’s age, gender, race, education, employment, years post HTx, health literacy, language congruency, and comorbidities, level of CIM as assessed by both patients and clinicians was significantly associated with trust in the HTx team (odds ratio (OR)=1.85, p&lt;.001; OR=1.35, p=.012, respectively). Patients from centers with higher levels of CIM were more likely to trust their HTx team. Lastly, only ‘ time spent on patient visits ’ significantly moderated the relationship between level of CIM (PACIC and CIMI) and trust (OR=1.61, p=.037; OR=1.56, p=.048, respectively), wherein the impact of time in fostering trust towards the HTx team was greater when level of CIM was high. In conclusion, level of CIM (assessed from patients’ and clinicians’ perspectives) was positively associated with trust. Our findings also suggest that allotting more time for patients during follow-up visits is a relevant factor to consider to further optimize the HTx care ecosystem.
Treatment and Follow-up Care Associated With Patient-Scheduled Primary Care Telemedicine and In-Person Visits in a Large Integrated Health System
Authors: Mary Reed, Jie Huang, Ilana Graetz, Emilie Muelly, Andrea Millman, Catherine Lee
Journal: JAMA Network Open (2021)

Telemedicine visits can offer patients convenient access to a clinician, but it is unclear whether treatment differs from that with in-person visits or how often patients require in-person follow-up.To examine whether physician prescribing and orders differ between telemedicine and office visits, whether physicians conducting telemedicine visits are more likely to require in-person follow-up, and whether telemedicine visits are associated with more health events.This cohort study included all patients who scheduled primary care appointments through the patient portal of a large integrated health care delivery system newly implementing patient-scheduled video telemedicine visits from January 2016 to May 2018.Adjusted rates of any medication prescribed or laboratory tests or imaging ordered and rates of follow-up health care utilization (in-person visits, emergency department visits, and hospitalizations) within 7 days after the index visit, stratified by index primary care visit type, were generated using multivariable adjustment for patient, access, and clinical characteristics.This study included 1 131 722 patients (611 821 [54%] female; mean [SD] age, 43 [22] years) with 2 178 440 total appointments (307 888 [14%] telemedicine), of which 13.5% were for patients younger than 18 years, 22.2% were for patients 65 years or older, and 54.9% were for female patients. After adjustment, 38.6% (95% CI, 38.0%-39.3%) of video visits, 34.7% (95% CI, 34.5%-34.9%) of telephone visits, and 51.9% (95% CI, 51.8%-52.0%) of office visits had any medication prescribed; laboratory tests or imaging were ordered for 29.2% (95% CI, 28.5%-29.8%) of video visits, 27.3% (95% CI, 27.1%-27.5%) of telephone visits, and 59.3% (95% CI, 59.3%-59.4%) of clinic visits. After adjustment, follow-up visits within 7 days occurred after 25.4% (95% CI, 24.7%-26.0%) of video visits, 26.0% (95% CI, 25.9%-26.2%) of telephone visits, and 24.5% (95% CI, 24.5%-24.6%) of office visits. Adjusted emergency department visits and rates of hospitalizations were not statistically significantly different by primary care index visit type.In this cohort study of patient self-scheduled primary care telemedicine visits within ongoing patient-physician relationships, prescribing and orders were significantly lower for telemedicine visits than for clinic visits, with slightly higher follow-up office visits for telemedicine but no difference in health events (emergency department visits or hospitalizations). Video or telephone visits may be a convenient and efficient way to access primary care and address patient needs.
Adding Romidepsin to CHOEP in First Line Treatment of Peripheral T-Cell Lymphomas Does Not Improve the Response Rate: Final Analysis of Phase II PTCL13 Study
Authors: Annalisa Chiappella, Cristiana Carniti, Alessandro Re, Claudia Castellino, Andrea Evangelista, Valentina Tabanelli, Rosanna Ciancia, Lorella Orsucci, Antonello Pinto, Sara Veronica Usai, Annalisa Arcari, Fiorella Ilariucci, Francesca Gaia Rossi, Fabio Benedetti, Leonardo Flenghi, Chiara Ghiggi, Anna Lia Molinari, Vittorio Stefoni, Stefano Volpetti, Vittorio Ruggero Zilioli, Filippo Ballerini, Riccardo Bruna, Federica Cavallo, Gerardo Musuraca, Caterina Patti, Francesca Re, Monica Tani, Marzia Varettoni, Manuela Zanni, Anna Dodero, Stefano A Pileri, Giovannino Ciccone, Paolo Corradini
Journal: Blood (2021)
Automated Digital Notification of COVID-19 Diagnoses Through Text and Email Messaging — North Carolina, December 2020–January 2021
Authors: Laura Farrell, Crystal R. Almond, Deborah S. Porterfield, Victoria Mobley, Sydney A. Jones, Marina Smelyanskaya, Erika Samoff
Journal: MMWR Morbidity and Mortality Weekly Report (2021)

During October 3, 2020-January 9, 2021, North Carolina experienced a 400% increase in daily reported COVID-19 cases (1). To handle the increased number of cases and rapidly notify persons receiving a positive SARS-CoV-2 test result (patients), North Carolina state and local health departments moved from telephone call notification only to telephone call plus automated text and email notification (digital notification) beginning on December 24, 2020. Overall, among 200,258 patients, 142,975 (71%) were notified by telephone call or digital notification within the actionable period (10 days from their diagnosis date)* during January 2021, including at least 112,543 (56%) notified within 24 hours of report to North Carolina state and local health departments, a significantly higher proportion than the 25,905 of 175,979 (15%) notified within 24 hours during the preceding month (p<0.001). Differences in text notification by age, race, and ethnicity were observed. Automated digital notification is a feasible, rapid and efficient method to support timely outreach to patients, provide guidance on how to isolate, access resources, inform close contacts, and increase the efficiency of case investigation staff members.
TAK-981, a First-in-Class SUMO-Activating Enzyme Inhibitor, Combined with Rituximab in Adult Patients (Pts) with CD20-Positive Relapsed/Refractory (R/R) Non-Hodgkin Lymphoma (NHL): Phase 1 Data
Authors: Sarit Assouline, Amitkumar Mehta, Tycel Phillips, Lapo Alinari, Alexey V. Danilov, Stéphane Doucet, Steven I. Park, Deborah Berg, Alejandro Gomez-Pinillos, Alonzo Martinez, Bo Chao, Allison J Berger, John Gibbs, Sharon Friedlander, Christine K. Ward, Igor Proscurshim, Brenda W. Cooper, Paolo F Caimi
Journal: Blood (2021)
EXTH-29. DUAL TGFB AND PD1 BLOCKADE PROMOTES GERMINAL-CENTER B-CELL IMMUNE RESPONSES AGAINST GLIOBLASTOMA
Authors: Mark Dapash, David Hou, Brandyn Castro, Aida Rashidi, Peng Zhang, Roger Stupp, Jason Miska, Maciej Lesniak, Catalina Chang
Journal: Neuro-Oncology (2021)

Abstract In contrast to other malignancies such as melanoma and sarcoma, Glioblastoma (GBM) remains difficult to treat with immunotherapies. Recent studies have shown that positive immunotherapeutic responses are mediated by the accumulation of germinal-center-like B cells which are predictive of survival in patients treated with neoadjuvant PD1 blockade. In contrast, GBM-associated B-cells are scarce and the establishment of germinal-center like cells have not been observed. This study seeks to identify how B-cells are driven towards their immunosuppressive phenotypes in GBM and how this prevents immunotherapeutic efficacy. Utilizing single-cell RNA sequencing (scRNA-seq) in a CT2A murine glioma model, TGFb receptors 1 and 3 were identified as the most highly expressed inhibitory receptors on GBM-associated B cells. Furthermore, using scRNA-seq, TGFb1 was identified as the most highly expressed immunosuppressive cytokine in the TME, which was produced principally by tumor-associated myeloid cells (TAMCs). Inhibiting the myeloid compartment using intracranial anti-Gr1 antibody in combination with PD1 blockade resulted in B-cells exhibiting greater proliferation and differentiation into memory B-cells in addition to germinal-center-like B-cells. Further demonstrating B-cell functional reprogramming, autologous T cells isolated from spleens exhibited greater proliferation and robust anti-tumor cytotoxicity when cocultured with tumor-associated B-cells from the dual treatment group. Finally, inhibiting a5b8 integrin, a key complex in releasing active TGFb, increased tumor-infiltrating proliferating B-cells and conferred a long-term survival benefit in the CT2A murine model. Our results demonstrate that the immunosuppressive TME of GBM is influenced by the vital interplay between B-cells and the TME through TGFb signaling. This study highlights the potential therapeutic benefits of targeting the TGFb signaling pathway in conjunction with the current standard of care for GBM.
Comprehensive characterization of single-cell full-length isoforms in human and mouse with long-read sequencing
Authors: Luyi Tian, Jafar S. Jabbari, Rachel Thijssen, Quentin Gouil, Shanika L. Amarasinghe, Oliver Voogd, Hasaru Kariyawasam, Mei R. M. Du, Jakob Schuster, Changqing Wang, Shian Su, Xueyi Dong, Charity W. Law, Alexis Lucattini, Yair David Joseph Prawer, Coralina Collar-Fernández, Jin D. Chung, Timur Naim, Audrey Chan, Chi Hai Ly, Gordon S. Lynch, James G. Ryall, Casey J. A. Anttila, Hongke Peng, Mary Ann Anderson, Christoffer Flensburg, Ian Majewski, Andrew W. Roberts, David C. S. Huang, Michael B. Clark, Matthew E. Ritchie
Journal: Genome biology (2021)

A modified Chromium 10x droplet-based protocol that subsamples cells for both short-read and long-read (nanopore) sequencing together with a new computational pipeline (FLAMES) is developed to enable isoform discovery, splicing analysis, and mutation detection in single cells. We identify thousands of unannotated isoforms and find conserved functional modules that are enriched for alternative transcript usage in different cell types and species, including ribosome biogenesis and mRNA splicing. Analysis at the transcript level allows data integration with scATAC-seq on individual promoters, improved correlation with protein expression data, and linked mutations known to confer drug resistance to transcriptome heterogeneity.
Multi-Modality Imaging Reveals Structural Centrosome Aberrations As a Potential Driver of Chromosomal Instability in Early-Stage Plasma Cell Disorders
Authors: Sebastian Köhrer, Tobias Dittrich, Martin Schorb, Niels Weinhold, Isabella Haberbosch, Mandy Börmel, Gabor Pajor, Hartmut Goldschmidt, Carsten Müller-Tidow, Marc-Steffen Raab, Alexander Brobeil, Peter Dreger, Ute Hegenbart, Stefan Schönland, Yannick Schwab, Alwin Krämer
Journal: Blood (2021)
The Impact of the Central Carbon Energy Metabolism Transcriptome in the Pathogenesis and Outcomes of Multiple Myeloma
Authors: Laura A Evans, Shaji Kumar, Erik Jessen, Angela Dispenzieri, Prashant Kapoor, Francis K. Buadi, David Dingli, Martha Q. Lacy, Suzanne R. Hayman, Nelson Leung, Eli Muchtar, Rahma M Warsame, Taxiarchis Kourelis, Stephen J. Russell, Yi Lin, Mustaqeem A. Siddiqui, Jin Sung Jang, Robert A. Kyle, S. Vincent Rajkumar, Morie A. Gertz, Rafael Fonseca, Wilson I Gonsalves
Journal: Blood (2021)
Reply to: Correspondence on “EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis – 2021 update”
Authors: Annalisa Berzigotti, Emmanouil Tsochatzis, Jerome Boursier, Laurent Castera, Nora Cazzagon, Mireen Friedrich-Rust, Salvatore Petta, Maja Thiele
Journal: Journal of Hepatology (2021)
Abstract 12371: Genetic Deletion of Cystathionine Gamma Lyase in Endothelial Cells Exacerbates Cardiovascular Dysfunction in Heart Failure With Preserved Ejection Fraction
Authors: Huijing Xia, Zhen Li, Kyle B Lapenna, Thomas E Sharp, Karl H Moles, Josef Pfeilschifter, Karl-Friedrich Beck, Traci T Goodchild, David J Lefer
Journal: Circulation (2021)

Background: Endothelial dysfunction has been suggested as a central pathophysiological mechanism in heart failure with preserved ejection fraction (HFpEF). We reported that Cystathionine Gamma Lyase (CSE), one of the 3 hydrogen sulfide producing enzymes, expressed in endothelial cells is critical for maintaining normal endothelial function and protecting against myocardial ischemia/reperfusion injury. However, the role of endothelial CSE in HFpEF remains unknown. Method: Endothelial specific CSE knockout mice (EC-CSE KO, n=15) and CSE flox/flox control animals (n=6) were fed a high-fat diet (60% kcal from fat) and administered L-NAME (0.5 g/L in drinking water) for 18 weeks to induce HFpEF. Body weight and cardiac function (echocardiography and doppler imaging) were monitored every 4 weeks. Invasive left ventricular hemodynamic procedures were performed and vascular reactivity was measured in isolated thoracic aorta at 18 weeks. Results: Baseline body weight, ejection fraction (EF), the ratios of E/A and E/E’ were not different between EC-CSE KO and controls. At 12 &amp; 16 weeks following HFD and L-NAME, E/E’ ratios were significantly higher in EC-CSE KO compared to controls (p &lt; 0.05), with normal EF in both groups. At 18 weeks of HFpEF, a 33.3% of mortality was observed in the EC-CSE KO group while no mortality was shown in control. In addition, left ventricular end-diastolic pressure (LVEDP) was higher (p &lt; 0.01) and aortic vasorelaxation maximal response to acetylcholine was lower (p &lt; 0.01) in EC-CSE KO compared to controls. Conclusion: Genetic deletion of CSE in vascular endothelial cells exacerbates cardiac diastolic dysfunction, promotes vascular dysfunction, and increases mortality in HFpEF. Studies are currently underway to define the protective role of endothelial CSE in HFpEF.
Do “knowledge attributions” involve metarepresentation just like belief attributions do?
Authors: Rachel Dudley, Ágnes Melinda Kovács
Journal: Behavioral and Brain Sciences (2021)

The authors distinguish knowledge and belief attributions, emphasizing the role of the former in mental-state attribution. This does not, however, warrant diminishing interest in the latter. Knowledge attributions may not entail mental-state attributions or metarepresentations. Even if they do, the proposed features are insufficient to distinguish them from belief attributions, demanding that we first understand each underlying representation.
Reducing Length of Stay for Patients with Acute Myeloid Leukemia Receiving Inpatient High-Dose Cytarabine Consolidation Chemotherapy
Authors: David O Riley, Caroline Jones, Amy L Morris, Jeremy M Sen, Nicholas J Schmidt, Alana Ferrari, Joshua Humphrey, Jenna VanHoose, Jenna Schlefman, Firas El Chaer, Michael K Keng
Journal: Blood (2021)
The Ublituximab-Umbralisib (U2) Drug Regimen Potentiates the Activity of the Novel CD47-CD19 Bispecific Antibody, TG-1801, through the Activation of the G Protein-Coupled Receptor EBI2/GPR183
Authors: Emmanuel Normant, Marcelo Lima Ribeiro, Nuria Profitos-Peleja, Pedro Blecua, Diana Reyes-Garau, Juliana Carvalho Santos, Marc Armengol, Miranda Fernández-Serrano, Hari P. Miskin, Gael Roue
Journal: Blood (2021)
Survival of Mantle Cell Lymphoma in the Era of Bruton Tyrosine Kinase Inhibitors: A Population-Based Analysis
Authors: Mengyang Di, Can Cui, Shalin K. Kothari, Amer M. Zeidan, Nikolai Podoltsev, Natalia Neparidze, Rory M. Shallis, Rong Wang, Xiaomei Ma, Scott F. Huntington
Journal: Blood (2021)
Neutralization of Inflammasome-Processed Cytokines Reduces Inflammatory Mechanisms and Leukocyte Recruitment in the Vasculature of TNF-α-Stimulated Sickle Cell Disease Mice
Authors: Lidiane S. Torres, Erica M.F. Gotardo, Flávia Costa Leonardo, Pamela L. Brito, Irmgard Förster, Jiri Kovarik, Fernando Ferreira Costa, Nicola Conran
Journal: Blood (2021)
A Phase 1 Trial of Adct-602, a CD22 Targeting Antibody Drug Conjugate Bound to PBD Toxin in Adult Patients with Relapsed or Refractory CD22+ B-Cell Acute Lymphoblastic Leukemia
Authors: Nitin Jain, Elias J. Jabbour, Marina Konopleva, Naveen Pemmaraju, Philip A. Thompson, Nicholas J. Short, Tapan M. Kadia, Gautam Borthakur, Naval Daver, Courtney D. DiNardo, Ibrahim Aldoss, Robin Cook, Farhad Ravandi, Hagop Kantarjian
Journal: Blood (2021)
Abstract 9510: How Dose Body Water Composition Change Around Cardiopulmonary Bypass Surgery of Children with Congenital Heart Disease? -Assessing by Bioelectrical Impedance Analysis
Authors: Haruka Obinata, Satoshi Yasukochi, Ryusuke Numata, Kohsuke Yonehara, Takeshi Konuma, Yohei Akazawa, Kohta Takei, Kiyohiro Takigiku
Journal: Circulation (2021)

Introduction: Although the management of body water balance on cardiac surgery with cardiopulmonary bypass (CPB), especially in children, is essential, little is known how body water composition changes around CPB. We aim to evaluate a change of intracellular (ICW), extracellular (ECW), and total body water composition (TBW) before and after CPB, using bioelectrical impedance analysis (BIA). Hypothesis: There is a possibility that the fluid distribution and water balance change depends on intraoperative water balance management and age. Then we investigate the impact of (1) intraoperative water balance management and (2) age at operation on changes of body water composition. Methods: The forty-five children weighing over 5Kg (Age ranges 3mo-11yo) were enrolled to this study. The body water balance was measured at before, at immediately after CPB, at 1 day, and at 2 days, respectively. Each parameter was compared by the factor of intraoperative water balance and that of age at operation. Results: The minus water balance during CPB results in significant shortage of ICW which not fully recovered by 2 days after CPB (Figure A). Cases &gt;2yo developed a decrease of ICW and ECW 2 days after CPB, while those &lt;2yo increased (Figure B). Conclusions: The body water composition significantly changes along CPB than expected. Care must be taken to prevent a harmful dehydration by controlling intraoperative water balance management and by age on the basis of BIA.
Abstract 10287: Trends in Cardiovascular Death Rates Among Women Veterans
Authors: Ramin Ebrahimi, Jennifer Sumner, Kristine Lynch, Benjamin Viernes, Chi-Hong Tzeng, paul dennis, Michelle Treadwell, Carlos Alvarez, Elizabeth Yano, Laurie A Shroyer, Jeannie Beckham
Journal: Circulation (2021)

Introduction: Based on data from the Centers for Disease Control and Prevention (CDC), during 2000-2017 the age-adjusted death rate from diseases of the heart/Cardiac Death (CD) for women in United States of America (US) decreased from 210.9 to 129.6 per 100,000 person-years (39% reduction). Recent trends in CD for women Veterans is not known. The goals of this project were to evaluate trends in CD in women Veterans from 2000-2017 and compare these trends to the corresponding national trends available through CDC (https://wonder.cdc.gov/ucd-icd10.html). Methods: Using the national Veterans Affairs (VA) electronic medical records (EMR), all women who visited any VA between 1/1/2000 to 12/31/2017 were identified. Vital status and cause of death were obtained by linking National Death Index (NDI) database to the VA cohort. CD was identified by underlying cause of death defined by International Classification of Disease Tenth Revision diagnostic codes (ICD-10). The same ICD-10 codes used by CDC to identify CD were used in the analysis of the VA cohort (I00-I09,I11,I13,I20-I51). Crude and age-standardized mortality rates were calculated overall and by calendar year. The 2000 US Standard Population was used as the reference population. Results: During the study period, 817,912 women Veterans had at least one visit at a VA medical center in US. Overall, 84,897 women died during the study period with 19,022 (22.4%) being heart related death. Figure #1 reveals the age-adjusted CD for US women in general, and women Veterans. Conclusions: Discordant from the national trend, age-adjusted CD among women Veterans has increased by more than 49%, from 2000 to 2017. In 2017, age-adjusted CD for women Veterans was more than twice the rate for US women. These results re-enforce the recent call to action to better understand and improve cardiovascular health for women Veterans.
Multiple Painless Subcutaneous Nodules on the Cheek of an Immunocompetent Man
Authors: Soufila Kudukkil Thazhathuveettil, Hitaishi Mehta, Keshavamurthy Vinay
Journal: JAMA Dermatology (2021)

A man in his 30s employed as a painter presented with multiple painless nodules on his right cheek and episodic breathlessness, cough, and wheezing with expectoration of brownish sputum. What is your diagnosis?
Real-world comorbidities of atopic dermatitis in the US adult ambulatory population
Authors: Youkyung S. Roh, Amy H. Huang, Nishadh Sutaria, Una Choi, Shannon Wongvibulsin, Justin Choi, Zachary A. Bordeaux, Varsha Parthasarathy, Junwen Deng, Deepa P. Patel, Joseph K. Canner, Anna L. Grossberg, Shawn G. Kwatra
Journal: Journal of the American Academy of Dermatology (2021)
Co-Targeting Intrinsic and Extrinsic Apoptosis to Maximize Cell Death Induction in Venetoclax-Resistant AML Cells
Authors: Bing Z Carter, Wenjing Tao, Lauren B Ostermann, Hong Mu-Mosley, Po Yee Mak, Steffen Boettcher, Yuki Nishida, Ran Tao, Eric Lang, Yifan Zhai, Dajun Yang, Michael Andreeff
Journal: Blood (2021)