Agranulocytosis Induced by Nonchemotherapy Drugs
Authors: Sherif B. Mossad
Journal: Annals of Internal Medicine (2008)

Letters19 February 2008Agranulocytosis Induced by Nonchemotherapy DrugsSherif B. Mossad, MDSherif B. Mossad, MDFrom The Cleveland Clinic, Cleveland, OH 44195.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-4-200802190-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with interest the report by Andersohn and colleagues (1). I expected to see ganciclovir or its prodrug valganciclovir on the list of drugs with definite or probable causality for agranulocytosis. I conducted a MEDLINE search for published reports from 1950 to April 2007 using the Medical Subject Heading terms agranulocytosis and ganciclovir. I found several reports describing this association, both in allogeneic bone marrow transplant recipients (2) and patients with AIDS (3). Prevention (4) or treatment (5) with hematopoietic growth factors is also effective in these patient populations.Sherif B. Mossad, MDThe Cleveland ClinicCleveland, OH ...References1. Andersohn F, Konzen C, Garbe E. Systematic review: agranulocytosis induced by nonchemotherapy drugs. Ann Intern Med. 2007;146:657-65. [PMID: 17470834] LinkGoogle Scholar2. Salzberger B, Bowden RA, Hackman RC, Davis C, Boeckh M. Neutropenia in allogeneic marrow transplant recipients receiving ganciclovir for prevention of cytomegalovirus disease: risk factors and outcome. Blood. 1997;90:2502-8. [PMID: 9310503] CrossrefMedlineGoogle Scholar3. Morbidity and toxic effects associated with ganciclovir or foscarnet therapy in a randomized cytomegalovirus retinitis trial. Studies of ocular complications of AIDS Research Group, in collaboration with the AIDS Clinical Trials Group. Arch Intern Med. 1995;155:65-74. [PMID: 7802522] CrossrefMedlineGoogle Scholar4. Reynoso Gomez E, Duenas Gonzalez A, Miranda Lopez E, Sobrevilla Calvo P, Donis Hernandez J, Texcocano Becerra J, et al. [Prevention of myelotoxicity in a case of bone marrow transplantation using granulocyte-macrophage colony-stimulating factor along with ganciclovir]. Revista de Investigacion Clinica. 1996;48:55-8. MedlineGoogle Scholar5. Dubreuil-Lemaire ML, Gori A, Vittecoq D, Panelatti G, Tharaux F, Palisses R, et al. Lenograstim for the treatment of neutropenia in patients receiving ganciclovir for cytomegalovirus infection: a randomised, placebo-controlled trial in AIDS patients. Eur J Haematol. 2000;65:337-43. [PMID: 11092465] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From The Cleveland Clinic, Cleveland, OH 44195.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSystematic Review: Agranulocytosis Induced by Nonchemotherapy Drugs Frank Andersohn , Christine Konzen , and Edeltraut Garbe Agranulocytosis Induced by Nonchemotherapy Drugs Sridhar Mani Agranulocytosis Induced by Nonchemotherapy Drugs Frank Andersohn , Christine Konzen , and Edeltraut Garbe Agranulocytosis Induced by Nonchemotherapy Drugs Chaker Ben Salem , Raoudha Slim , Houssem Hmouda , and Kamel Bouraoui Agranulocytosis Induced by Nonchemotherapy Drugs Luisa Ibáñez , Xavier Vidal , and Joan-Ramon Laporte Metrics Cited ByIdiosyncratic Drug-Induced Neutropenia and Agranulocytosis in Elderly PatientsAGRANULOCYTOSIS ASSOCIATED WITH TRANDOLAPRIL-VERAPAMIL COMBINATIONAbnormalities in leukocyte morphology and numberCurrent awareness: Pharmacoepidemiology and drug safety 19 February 2008Volume 148, Issue 4Page: 320KeywordsAIDSBone marrowConflicts of interestDrugsHematopoietic growth factorsPopulation statistics ePublished: 19 February 2008 Issue Published: 19 February 2008 CopyrightCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...