tbuckley/cabot-search huggingface dataset:
Rise Up
Authors: Lauren F. Collins
Journal: Annals of Internal Medicine (2020)

On Being a Doctor7 January 2020Rise UpLauren F. Collins, MDLauren F. Collins, MDEmory University School of Medicine, Atlanta, Georgia (L.F.C.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M19-1996 Audio Reading - “Rise Up” Audio. Virginia Hood, MD, reads “Rise Up” by Lauren F. Collins, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail He came to us from outside the city. He was diagnosed 5 years ago but felt bad for 3 years. His wondering eyes communicated an eagerness to share and be trusted. After not so stealthily glancing at the tightly shut door, he leaned in close. Whispering, he disclosed the “four-drug cocktail” he took every day: “No, ma’am, do I miss a dose!” It made no difference. In fact, this gentleman felt worse—nausea, inability to eat, weight loss, fatigue.I say “gentleman,” but he was really just a boy. Within 5 minutes of our knowing each other, he cried on my ... Author, Article, and Disclosure InformationAffiliations: Emory University School of Medicine, Atlanta, Georgia (L.F.C.)Corresponding Author: Lauren F. Collins, MD, Emory University School of Medicine, 49 Jesse Hill Jr. Drive, Atlanta, GA 30303; e-mail, lauren.frances.[email protected]edu. PreviousarticleNextarticle Advertisement Audio Reading - “Rise Up” Audio. Virginia Hood, MD, reads “Rise Up” by Lauren F. Collins, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 7 January 2020Volume 172, Issue 1Page: 67-68KeywordsAIDSAntiretroviral therapyHIVHIV infectionsHIV preventionInpatientsPsychiatry and mental healthSubstance abuseViral loadWeight loss ePublished: 7 January 2020 Issue Published: 7 January 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Re: Book review of dynamic electrocardiographic recording
Authors: G. F. Fletcher
Journal: JAMA (1979)

<h3>To the Editor.—</h3> Agent Orange is an herbicide containing equal parts of 2,4-dichlorophenoxyacetic acid and 2,4,5-trichlorophenoxyacetic acid. It was used extensively in Vietnam as a defoliant. A toxic contaminant is dioxin, 2,3,7,8 tetrachlorodibenzo-<i>p</i>-dioxin. A ten-month study of 78 Vietnam veterans who claimed exposure to Agent Orange yielded many findings: 85% of the men experienced a rash that was resistant to treatment. Using immunofluorescence in one patient, a skin biopsy specimen showed intraepithelial and intercellular IgA, IgG, and IgM. In 53% of the patients, the rash was aggravated by sunlight. Joint pain occurred in 71%, stiffness in 59%, and swelling in 45%. Hypersomnolence occurred in 44% of the men and extreme fatigue in 80%. Sinus bradycardia and premature ventricular contractions were not infrequent. Persistent neurological complaints were tingling (55%), numbness (60%), dizziness (69%), headache (35%), and autonomic dyscontrol (18%). Severe psychiatric manifestations were depression (73%), suicidal attempts (8%), and
Angiology, Baltimore
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma
Authors: Mira Patel, Jennifer Kim, Debebe Theodros, Christopher Jackson, Ada Tam, Esteban Velarde, Betty Tyler, Xiaobu Ye, Henry Brem, Mark Selby, Charles Drake, Drew Pardoll, Michael Lim
Journal: Journal for ImmunoTherapy of Cancer (2015)

Meeting abstracts Glioblastoma (GBM) is a poorly immunogenic neoplasm treated with local radiation. Despite the standard of care, median survival remains low. Immunotherapy has synergized with stereotactic radiosurgery (SRS) in murine GBM, as radiation promotes a pro-inflammatory tumor
Wounded Warriors
Authors: Mike Mitka
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Screening for genetic haemochromatosis in blood samples with raised alanine aminotransferase Reply
Authors: J. PATERSON
Journal: Gut (2001)

Editor,—Bhavnani et al (Gut 2000; 46 :707–10) claim to have identified 12 patients homozygous for C282Y or with compound heterozygocity at a cost of only £117 per patient identified. This astonishingly low total of £1400 allowed them to: M Bhavnani,manju.bhavnani{at}wiganlhs-tr.nwest.nhs.uk
Diagnostic accuracy of molecular tumor profiling in determining the tissue of origin in adult patients with cancer of unknown primary: A meta-analysis.
Authors: Rowena Torres Inocencio, Kavitha Kesari, Susan Smith
Journal: Journal of Clinical Oncology (2017)

e23092 Background: Appropriate cancer treatment requires determination of the primary site of origin. The standard of care for diagnosing Cancer of unknown primary (CUP) based on the 2016 NCCN Guidelines is a comprehensive clinical work-up including biopsy and immunohistochemistry (IHC). However, IHC was able to identify a primary tumor in only 25% of CUP. Molecular tumor profiling (MTP) validation studies demonstrated sensitivities of 74-89% and specificities of 95-99%. Only a few studies with small sample sizes using MTP to diagnose the primary in CUP have been performed yielding variable results. This study aims to evaluate the diagnostic accuracy of MTP in determining the tissue of origin in adult patients with CUP. Methods: Literature search included articles published in any language indexed in MEDLINE and Cochrane. A Google Scholar search and a review of all published articles’ references were performed. Unpublished studies and abstracts from conference proceedings were also reviewed. Studies involving adult patients with CUP who underwent both MTP and clinical evaluation with IHC were identified. Articles were included if they had primary data sufficient to calculate both sensitivity and specificity. Methodological qualities of the included studies were evaluated using the QUADAS-2 tool. Data was analyzed using Review Manager 5.3 and MetaDiSc 1.4. Results: Seven studies with 549 patients were analyzed. MTP was found to have a pooled sensitivity of 89% (95% CI 0.85-0.92)and pooled specificity of 74% (95% CI 0.67-0.80)with pooled positive and negative likelihood ratios of 2.97 (95% CI 1.17-7.63) and 0.20 (95% CI 0.07-0.51), respectively. Area under the curve was measured to be 0.9107. Conclusions: This meta-analysis suggests that MTP could be useful in determining the tissue of origin in adult patients with CUP. With an area under the curve of 0.9107, it is an excellent diagnostic test. The results showed considerable heterogeneity as expected in meta-analyses of diagnostic test accuracy. In this case, it may be due to variability among the MTP assays used which may reflect different cutoffs.
Medical News
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reflections on the Doctor's Anguish
Authors: Edward Anthony Oppenheimer
Journal: Annals of Internal Medicine (1993)

Letters1 January 1993Reflections on the Doctor's AnguishEdward Anthony Oppenheimer, MDEdward Anthony Oppenheimer, MDSouthern California Permanente Medical Group; Los Angeles, CA 90027Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-1-199301010-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:It is a physician's first obligation to ensure that the diagnosis, prognosis, and options are properly evaluated before making a recommendation to the patient and before responding to a patient's request. If the diagnosis of impending respiratory failure had been made promptly in November 1990, when the patient had progressive dyspnea, perhaps he could have explored his options before emergency hospitalization and intubation. After he stabilized in the hospital, experienced respiratory care could have helped him to reestablish speech using a cuffless tracheostomy or by deflating the cuff [2], possibly adding a Passy-Muir tracheostomy speaking valve (Irvine, ...References1. Miles JE, Susan WT. Disconnecting a ventilator at the request of a patient who knows he will then die: the doctor's anguish. Ann Intern Med. 1992; 117:254-6. Google Scholar2. Bach JR, Alba AS. Tracheostomy ventilation. A study of efficacy with deflated cuffs and cuffless tubes. Chest. 1990; 679-83. Google Scholar3. Herr SS, Bostrom BA, Barton RS. No place to go: refusal of life-sustaining treatment by competent persons with physical disabilities. Issues in Law & Medicine. 1992;8:3-36. Google Scholar4. American Thoracic Society Bioethics Task Force. Withholding and withdrawing life-sustaining therapy. Am Rev Respir Dis. 1991; 144: 726-31. Google Scholar5. Wilson WC, Smedira NG, Fink C, McDowell JA, Luce JM. Ordering and administration of sedatives and analgesics during the withholding and withdrawal of life support from critically ill patients. JAMA. 1992; 267:949-53. Google Scholar Author, Article, and Disclosure InformationAuthors: Edward Anthony Oppenheimer, MDAffiliations: Southern California Permanente Medical Group; Los Angeles, CA 90027 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1993Volume 118, Issue 1Page: 78-80KeywordsDyspneaHospitalizationsIntubationPoliomyelitisRespiratory failureSwallowingTracheostomyVentilators ePublished: 15 August 2000 Issue Published: 1 January 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Bureau of Investigation
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Brain tumors in man and animals: report of a workshop.
Journal: Environmental Health Perspectives (1986)

This report summarizes the results of a workshop on brain tumors in man and animals.Animals, especially rodents are often used as surrogates for man to detect chemicals that have the potential to induce brain tumors in man.Therefore, the workshop was focused mainly on brain tumors in the F344 rat and B6C3F1 mouse because of the frequent use of these strains in long-term carcinogenesis studies.Over 100 brain tumors in F344 rats and more than 50 brain tumors in B6C3F1 mice were reviewed and compared to tumors found in man and domestic or companion animals.In the F344 rat, spontaneous brain tumors are uncommon, most are of glial origin, and the highly undifferentiated glioblastoma multiforme, a frequent tumor of man was not found.In the B6C3F1 mouse, brain tumors are exceedingly rare.Lipomas of the choroid plexus and meningiomas together account for more than 50% of the tumors found.Both rodent strains examined have low background rates and very little variability between control groups.
Artificial Pacing for Heart Block
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE REACTION OF MORNING URINE
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Infant Mortality
Authors: Samuel Sepkowitz
Journal: JAMA (1982)

<h3>To the Editor.—</h3> In a recent editorial about infant mortality (1982;247: 1027), Paneth warns about the hazards of comparing infant mortality rates between countries; he notes how irregularly birth weights are recorded throughout the world, and states that "crude mortality rates are, more often than not, profoundly misleading." Paying little heed to his own warnings, he proceeds to place the United States back into an international infant mortality race where it ties for 16th place. To complete the invidious comparison, he cites a relatively high rate of infant mortality in the United States and the superior size and gestational age of European and Japanese counterparts. These attempts to use crude birth weights and birth-weight-specific mortality rates are misleading and inappropriate. Many countries report incomplete or provisional data for mortality of infants weighing less than 1,000 g, the weight group in which the largest number of deaths occurs. And skepticism shades
PROGNOSIS OF EPILEPSY.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TURKEY
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Unresolving pneumonia
Authors: R. E. Greene
Journal: JAMA (1968)

Dr. Reginald E. Greene: A 56-year-old white man was admitted to this hospital after repeated episodes of hemoptysis over a three-month period. His illness began with fatigue, malaise, hoarseness, and cough. He ran a low-grade fever and was treated with two courses of penicillin for pneumonia. During the second course of antibiotic therapy, he noted a single episode of a dull ache in the right anterior portion of the chest. He had been a heavy smoker for years and was transiently exposed to a brother-in-law who had died of tuberculosis recently. Because of the absence of significant symptomatic improvement, he was referred to this hospital for admission. Pertinent physical findings included a normal temperature and decreased breath sounds over the right middle lobe area with crepitant rales. The findings of the remainder of the examination were normal. An intermediate strength purified protein derivative (PPD) test was strongly positive. Other laboratory