tbuckley/cabot-search huggingface dataset:
Effectiveness of an Internet-Based Self-Help Intervention versus Public Mental Health Advice to Reduce Worry during the COVID-19 Pandemic: A Pragmatic, Parallel-Group, Randomized Controlled Trial
Authors: Hanna Heckendorf, Dirk Lehr, Leif Boß
Journal: Psychotherapy and Psychosomatics (2022)

The mental health burden for the general population due to the COVID-19 pandemic has been highlighted. Evidence on effective, easily accessible public health interventions to reduce worry, a major transdiagnostic risk-factor for, e.g., anxiety and depression, is scarce.In a pragmatic randomized controlled trial, we aimed to assess whether an internet cognitive-behavioral self-help intervention could reduce worry more than public mental health advice in the general population.Eligible internet users above the age of 18 were recruited from the German general population and randomly assigned, to either get.calm-move.on (GCMO), a 10-day unguided, internet-based self-help intervention, or mental health advice waiting group (MHA-W, receiving officially endorsed mental health recommendations). The primary outcome was level of worry, using the Penn State Worry Questionnaire (PSWQ), 2 weeks after randomization. Baseline assessment and 2-month and 6-month follow-ups were conducted. The trial was registered at the German Clinical Trials Registry (DRKS00021153).Between April 7, 2020 and December 11, 2020, we randomly assigned 351 individuals to receive either GCMO (n = 175) or MHA-W (n = 176). Participants receiving GCMO (PSWQ = 46.6; change -10.3) reported significantly less worrying at post-intervention (F1,219 = 12.9; p < 0.001; d = 0.38) than MHA-W controls (PSWQ = 51.6; change -5.1). Improvements were also seen on most secondary outcomes, including symptoms of anxiety and depression, general well-being, resiliency, and emotion regulation skills. Improvements made from baseline were stable until the 6-month follow-up.This internet-based self-help intervention providing cognitive-behavioral techniques to cope with the threatening pandemic situation is effective in reducing worry in the general population and should complement existing and potentially effective mental health recommendations.
СОДЕРЖАНИЕ СЫВОРОТОЧНОГО ГАСТРИНА У ПАЦИЕНТОВ С РЕФЛЮКС-ГАСТРИТОМ
Authors: Yu.M. Stepanov, L.N. Mosiychuk, A.N. Kovalenko
Journal: GASTROENTEROLOGY (2014)

В статье представлены результаты исследования уровня базального гастрина и его взаимосвязей при хроническом рефлюкс-гастрите. Установлено, что у 100 % больных уровень гастрина был повышен. Он напрямую зависел от концентрации желчных кислот в желудочном соке, наличия Н.pylori-инфекции, защелачивания желудка. Таким образом, дуоденогастральный рефлюкс способствует развитию гипергастринемии, что может приводить к возникновению хронического гастрита.
A Prognosis for Vision in Diabetic Retinopathy
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Infectious disease surveillance update
Authors: Ruth Zwizwai
Journal: The Lancet Infectious Diseases (2019)

As of Dec 4, the Samoan Ministry of Health has reported 4052 cases of measles since the outbreak began in September. 60 measles-related deaths have been reported whilst 177 measles cases were hospitalised as of Dec 4, including critically ill patients such as children in intensive care unit (n=20) as well as pregnant women (two) and neonatal cases (two). 1246 cases have been hospitalised so far during this outbreak. In response to the outbreak, door-to-door mass vaccination was undertaken on Dec 5–6, across the country.
Committee on Foods
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A drug rash that can mimic the very cancer the drug treats
Journal: British Journal of Dermatology (2022)

Abstract Linked Article: Trum et al. Br J Dermatol 2022; 186:153–166. Cutaneous T-cell lymphoma (CTCL) are a rare group of cancers that develop in the skin from T cells (a type of white blood cell). Mogamulizumab is a promising treatment for CTCL, but its most common adverse effect is a drug rash named mogamulizumab-associated rash (MAR). MAR remains poorly described, and it is difficult to tell apart from CTCL itself. In this study, we reviewed past records and followed up with all 24 patients with CTCL who were treated with mogamulizumab since it was approved for use in 2018 and seen by our institution in the USA. We saw a higher rate of MAR among our patients (71%) than previously reported, however, most of our patients had a specific type of CTCL (Sézary syndrome). Interestingly, most patients that developed MAR also responded well to mogamulizumab (88%), a higher rate than previously reported. Whereas patients that did not develop MAR did not respond to mogamulizumab as often. In our article, we describe the diverse patterns of MAR, which may or may not mimic CTCL both visually on the skin and under the microscope. A drug rash that can mimic the very disease the drug treats is dangerous to misdiagnose, especially if the rash is a sign that the drug is working; the drug might be discontinued before it has a chance to have a full effect on the cancer. Care providers should greet MAR as a sign that mogamulizumab works for that patient, and only consider discontinuing it if MAR is intolerable/resistant to treatment or the patient with CTCL goes into remission (i.e. the signs and symptoms of the cancer are reduced or gone) as a result of mogamulizumab. Linked Article: Trum et al. Br J Dermatol 2022; 186:153–166.
Excessive doses of drugs
Authors: T. E. Finucane
Journal: JAMA (1984)

<h3>In Reply.—</h3> I am most grateful for the interesting letters received since publication of the case report on spontaneous fistula. Two cases displaying features similar to that case report have come to my attention, including the interesting article by Rubio and Morris<sup>1</sup>as well as a lucid report by George L. Hines, MD et al.<sup>2</sup>Neither case appeared in the extensive MEDLINE search I reviewed in preparation of the original article. I recently searched the<i>Cumulated Index Medicus</i>, volumes 19 (1978), 20 (1979), and 21 (1980), and could find neither of these reports listed or indexed under the appropriate author and subject listings, although they are certainly worthy of such ready access in the medical literature. Also of interest is a case in Dr F. J. Kazmier's<sup>3</sup>series of aortocaval fistulas (case 6), which varies from the aforementioned cases in that a large pseudoaneurysm, which had formed
Innate‐like bystander‐activated CD38+HLA‐DR+CD8+T cells play a pathogenic role in patients with chronic hepatitis C
Authors: Chien‐Hao Huang, Jian‐He Fan, Wen‐Juei Jeng, Shu‐Ting Chang, Chan‐Keng Yang, Wei Teng, Tsung‐Han Wu, Yi‐Chung Hsieh, Wei‐Ting Chen, Yi‐Cheng Chen, I‐Shyan Sheen, Yung‐Chang Lin, Chun‐Yen Lin
Journal: Hepatology (2022)

HCV-specific T cells are few and exhausted in patients with chronic hepatitis C (CHC). Whether these T cells are responsible for the liver damage and fibrosis is still debated. However, cluster of differentiation 38-positive (CD38+ ) human leukocyte antigen DR-positive (HLA-DR+ ) CD8+ T cells are regarded as bystander CD8+ T cells that cause liver injury in acute hepatitis. We propose that these innate CD8+ T cells play a pathogenic role in CHC.Lymphocytes from peripheral blood were obtained from 108 patients with CHC and 43 healthy subjects. Immunophenotyping, functional assays, T-cell receptor (TCR) repertoire, and cytotoxic assay of CD38+ HLA-DR+ CD8+ T cells were studied.The percentage of CD38+ HLA-DR+ CD8+ T cells increased significantly in patients with CHC. These cells expressed higher levels of effector memory and proinflammatory chemokine molecules and showed higher interferon-γ production than CD38- HLA-DR- CD8 T cells. They were largely composed of non-HCV-specific CD8+ T cells as assessed by HLA-A2-restricted pentamers and next-generation sequencing analysis of the TCR repertoire. In addition, these CD38+ HLA-DR+ CD8+ T cells had strong cytotoxicity, which could be inhibited by anti-DNAX accessory molecule 1, anti-NKG2 family member D, and anti-natural killer NKp30 antibodies. Lastly, the percentage of CD38+ HLA-DR+ CD8+ T cells was significantly associated with liver injury and fibrosis and decreased significantly along with serum alanine aminotransferase normalization after successful direct-acting antiviral treatment.The TCR-independent, cytokine-responsive bystander CD38+ HLA-DR+ CD8+ T cells are strongly cytotoxic and play a pathogenic role in patients with CHC.
Exercise medicine and physical activity promotion: core curricula for US medical schools, residencies and sports medicine fellowships: developed by the American Medical Society for Sports Medicine and endorsed by the Canadian Academy of Sport and Exercise Medicine
Authors: Irfan Asif, Jane S Thornton, Stephen Carek, Christopher Miles, Melissa Nayak, Melissa Novak, Mark Stovak, Jason L Zaremski, Jonathan Drezner
Journal: British Journal of Sports Medicine (2022)

Regular physical activity provides a variety of health benefits and is proven to treat and prevent several non-communicable diseases. Specifically, physical activity enhances muscular and osseous strength, improves cardiorespiratory fitness, and reduces the risk of hypertension, coronary heart disease, stroke, type 2 diabetes, mental health disorders, cognitive decline and several cancers. Despite these well-known benefits, physical activity promotion in clinical practice is underused due to insufficient training during medical education. Medical trainees in the USA receive relatively few hours of instruction in sports and exercise medicine (SEM). One reason for this shortage of instruction is a lack of curricular resources at each level of medical education. To address this need, the American Medical Society for Sports Medicine (AMSSM) assembled a group of SEM experts to develop curricular guidance for exercise medicine and physical activity promotion at the medical school, residency and sports medicine fellowship levels of training. After an evidence review of existing curricular examples, we performed a modified Delphi process to create curricula for medical students, residents and sports medicine fellows. Three training level-specific curricula emerged, each containing Domains, General Learning Areas, and Specific Learning Areas; options for additional training and suggestions for assessment and evaluation were also provided. Review and comment on the initial curricula were conducted by three groups: a second set of experts in exercise medicine and physical activity promotion, sports medicine fellowship directors representing a variety of fellowship settings and the AMSSM Board of Directors. The final curricula for each training level were prepared based on input from the review groups. We believe enhanced medical education will enable clinicians to better integrate exercise medicine and physical activity promotion in their clinical practice and result in healthier, more physically active patients.
&lt;TITLE&gt;Growing older in good health&lt;/TITLE&gt;
Journal: JAMA (2000)

public service of JAMA and the AMA.The information and recommendations appearing on this page are appropriate in most instances, but they are not a substitute for medical diagnosis.For specific information concerning your personal medical condition, JAMA and the AMA suggest that you consult your physician.This page may be reproduced noncommercially by physicians and other health care professionals to share with patients.Any other reproduction is subject to AMA approval.
The Student's Handbook of the Surgery of the Alimentary Canal.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CRITICISMS OF SOME SURGICAL TENDENCIES.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mortality in type B acute aortic dissections in the current era: Results from the International Registry of Aortic Dissection (IRAD) Toru Suzuki, Christoph A. Nienaber, Peter G. Hagan, Eduardo Bossone, Dan Gilon, Jeanna V. Cooper, David Bruckman, William F. Armstrong, Kim A. Eagle, Rajendra H. Mehta. University of Tokyo, Tokyo, Japan, University of Michigan for IRAD Investigators, Ann Arbor, MI
Journal: Journal of the American College of Cardiology (2001)
Coal workers' autopsy study
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Experimental induction of glomerulonephritis with group A streptococci
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of 1 year of pravastatin on coronary plaque regression assessed by intravascular ultrasound. Results of the ?Demonstration of Regression of Atherosclerosis by Ultrasonographic Assessment? (DRACULA) pilot trial Fadi Matar, Nehal Dessani, Seth Goldberg, Dawn Garret, J T. Sullebarger. Florida Cardiovascular Research Foundation, Tampa, FL
Journal: Journal of the American College of Cardiology (2001)
COVID-19: too little, too late?
Authors: None The Lancet
Journal: The Lancet (2020)

Although WHO has yet to call the outbreak of SARS-CoV-2 infection a pandemic, it has confirmed that the virus is likely to spread to most, if not all, countries. Regardless of terminology, this latest coronavirus epidemic is now seeing larger increases in cases outside China. As of March 3, more than 90 000 confirmed cases of COVID-19 have been reported in 73 countries. The outbreak in northern Italy, which has seen 11 towns officially locked down and residents threatened with imprisonment if they try to leave, shocked European political leaders.
<i>ERJ</i>Podcast January 2019: World Symposium on Pulmonary Hypertension
Journal: European Respiratory Journal (2019)

As part of the January issue, the European Respiratory Journal presents the latest in its series of podcasts. Section Editor Marc Humbert interviews Nazzareno Galiè (University of Bologna, Bologna, Italy) about a collection of articles in this issue arising from the Sixth World Symposium on Pulmonary Hypertension.
Exploratory analysis of the impact of prior immune checkpoint inhibitor (ICI) on trastuzumab deruxtecan (T-DXd; DS-8201) clinical outcomes and biomarkers (BM) in DESTINY-Gastric01 (DG-01), a randomized, phase 2, multicenter, open-label study in patients (pts) with HER2+ advanced gastric or gastroesophageal junction adenocarcinoma.
Authors: Kohei Shitara, Yung-Jue Bang, Satoru Iwasa, Naotoshi Sugimoto, Min-Hee Ryu, Daisuke Sakai, Hyun Cheol Cheol Chung, Yasushi Omuro, Hisato Kawakami, Hiroshi Yabusaki, Yasuhiro Sakamoto, Tomohiro Nishina, Koichiro Inaki, Yusuke Kuwahara, Fumitaka Suto, Masahiro Sugihara, Kaku Saito, Akihito Kojima, Kensei Yamaguchi
Journal: Journal of Clinical Oncology (2022)

322 Background: T-DXd is a HER2-targeting antibody-drug conjugate. In primary analyses of DG-01 (NCT03329690), T-DXd showed clinically meaningful improvement in objective response rate (ORR) and overall survival (OS) vs chemotherapy in the primary cohort of pts with HER2+ advanced gastric cancer (AGC; IHC3+ or IHC2+/ISH+; Shitara K et al. NEJM 2020;382:2419). In the context of emerging first-line ICI-based regimens in AGC, we conducted a post hoc analysis of T-DXd clinical outcomes and baseline BMs in pts with or without prior ICI. Methods: DG-01 primary cohort enrolled pts who progressed on ≥2 prior lines with centrally confirmed HER2+ AGC. Efficacy and safety were assessed in pts with or without prior ICI (defined as any ICI-related treatment received prior to T-DXd). Exploratory BM analysis in the T-DXd arm assessed RNA sequencing (RNAseq) of tumor biopsies and ctDNA of liquid biopsies taken immediately before T-DXd treatment. A linear regression model and Wilcoxon rank-sum test were used to identify differentially expressed genes and signature scores between pts with or without prior ICI. Results: Prior ICI was received in 35.2% (44/125) of pts treated with T-DXd and 27.4% (17/62) treated with chemotherapy. The table shows efficacy in pts with or without prior ICI. Safety data in the T-DXd arm were similar between pts with or without prior ICI, including adjudicated drug-related interstitial lung disease/pneumonitis; 9.1% (4/44) of pts with prior ICI and 9.9% (8/81) of pts without prior ICI. Among 34 T-DXd-treated pts with RNAseq data, 12 received prior ICI. Searching for differentially expressing genes (fold change ≥2, P≤0.01) identified multiple genes with a higher trend for expression in tumors with prior ICI, including immune-oncology (IO)-related molecules, CXCL9 and PD-1 (log 2 fold change 2.3 and 1.4, P=7.3e-05 and 2.8e-03, respectively). Furthermore, gene signature analysis showed a concurrent higher trend of multiple chemokine gene expressions in the prior ICI group. Conclusions: This exploratory analysis suggests that treatment with T-DXd results in better outcomes than chemotherapy regardless of prior ICI. Given a relatively small sample size, the relationship between changes in IO-related signatures and efficacy of T-DXd warrants further evaluation in larger cohorts. Clinical trial information: NCT03329690. [Table: see text]