tbuckley/cabot-search huggingface dataset:
Report of the American Humane Association on Vivisection and Dissection in Schools.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Patient Burden of Moderate-to-Severe Atopic Dermatitis (AD) in Children Aged &lt;12 Years: Results From 732 Patients in the PEDIatric STudy in Atopic Dermatitis (PEDISTAD) Observational Study
Authors: Amy Paller, Martti Antila, Danielle Marcoux, Isabel Betlloch, Yoko Kataoka, Chunyuan Liu, Thu Tong, Annie Zhang
Journal: Journal of Allergy and Clinical Immunology (2022)
ORGANIZATION SECTION
Journal: JAMA (1941)

<h3>MEDICAL LEGISLATION</h3><h3>MEDICAL BILLS IN CONGRESS</h3><h3>Changes in Status.—</h3> H. R. 4853 has been reported to the Senate, proposing to authorize the hospitalization of retired officers and enlisted men who are war veterans on a parity with other war veterans. H. R. 4905 has been reported to the Senate, proposing to facilitate standardization and uniformity of procedure relating to the determination of service connection of injuries or diseases alleged to have been incurred in or aggravated by active service in a war, campaign or expedition. H. R. 6135 was reported to the House with recommendation that it pass, proposing to authorize an additional appropriation of $150,000,000 to construct community facilities in defense areas, including hospitals, health centers and clinics. Subsequently the authorization for the additional appropriation contemplated by this bill was included in another pending bill, H. R. 6128, and that bill has passed the House. <h3>Bills Introduced.—</h3> S.
Asthma Mortality and Hospitalization Among Children and Young Adults— United States, 1980-1993
Journal: JAMA (1996)

Asthma is the most common chronic illness in childhood and is characterized by variable airflow obstruction with airway hyperresponsiveness. In the United States, asthma affects an estimated 14-15 million persons, including 4.8 million (6.9%) aged < 18 years. In 1993, asthma accounted for an estimated 198,000 hospitalizations and 342 deaths among persons aged < 25 years. To characterize national trends in mortality and hospitalizations attributable to asthma among children and young adults (persons aged < 25 years) during 1980-1993, CDC analyzed mortality data from its multiple cause-of-death files and hospitalization data from the National Hospital Discharge Survey. This report summarizes the results of that analysis, which indicate that asthma-related mortality and hospitalization rates are increasing among persons aged < 25 years.
Impact of Asthma, COPD, and ACO on the Prognosis of COVID-19
Authors: Eunyong Shin, Juhae Jin, Seo Young Park, Young sang Yoo, Ji-Hyang Lee, Jin An, Woo-Jung Song, Hyouk-Soo Kwon, You Sook Cho, Hee-Bom Moon, Jung-bok Lee, Tae-Bum Kim
Journal: Journal of Allergy and Clinical Immunology (2022)
Meaningful Respect for the Autonomy of Persons with “Completed Life”: An Analysis in Light of Empirical Research
Authors: M. L. Zomers, E. J. van Wijngaarden, J. J. M. van Delden, G. J. M. W. van Thiel
Journal: The American Journal of Bioethics (2022)

This article refers to:From Reciprocity to Autonomy in Physician-Assisted Death: An Ethical Analysis of the Dutch Supreme Court Ruling in the Albert Heringa Case
Wood's Medical and Surgical Monographs, Vol. i, No. 1.
Authors: None N. S. D.
Journal: JAMA (1889)

This is the first volume of a new series of books started by the well-known publishing house of Wm. Wood &amp; Co. They propose to issue a similar volume each month during the coming year. The series will be made up of monographs taken from the current literature of foreign lands. In the volume before us, and there is promised in the one to follow, two articles excerpted from English publications and one translated from the French. This first number is a volume of good proportions containing two hundred and fifty odd pages. It is bound in stiff paper covers. It is well printed on good paper. The first monograph by Jonathan Hutchinson fills one hundred and twelve pages; the second by Robert M. Simon, forty pages; and the third by Ferrand, ninety-nine pages. The only part of the volume we have read with care, as it appears here, is
Comprehensive Review of Chest Tube Management
Authors: Devon Anderson, Sarah A. Chen, Luis A. Godoy, Lisa M. Brown, David T. Cooke
Journal: JAMA Surgery (2022)

<h3>Importance</h3> Thoracostomy, or chest tube placement, is used in a variety of clinical indications and can be lifesaving in certain circumstances. There have been developments and modifications to thoracostomy tubes, or chest tubes, over time, but they continue to be a staple in the thoracic surgeon's toolbox as well as adjacent specialties in medicine. This review will provide the nonexpert clinician a comprehensive understanding of the types of chest tubes, indications for their effective use, and key management details for ideal patient outcomes. <h3>Observations</h3> This review describes the types of chest tubes, indications for use, techniques for placement, common anatomical landmarks that are encountered with placement and management, and an overview of complications that may arise with tube thoracostomy. In addition, the future direction of chest tubes is explored, as well as the management of chest tubes during the COVID-19 pandemic. <h3>Conclusions and Relevance</h3> Chest tube management is subjective, but the compilation of data can inform best practices and safe application to successfully manage the pleural space and ameliorate acquired pleural space disease.
Targeting myeloid-derived suppressor cells to enhance natural killer cell-based immunotherapy
Authors: Shweta Joshi, Andrew Sharabi
Journal: Pharmacology & Therapeutics (2022)

Myeloid-derived suppressor cells (MDSCs) are immune cells of the myeloid lineage that progressively accumulate in tumors and play an important role in promoting tumor growth. MDSCs interact with other immune cells present in the tumor microenvironment (TME) and utilize multiple mechanisms to promote immunosuppression. On the other hand, natural killer (NK) cells are cytotoxic cells of the innate immune system and work as one of the first lines of defense against tumors. However, the role of MDSCs in regulating or suppressing NK cells within the TME is poorly understood. This review discusses MDSC-associated immunosuppression, the mechanisms regulating communication between MDSCs and NK cells in the tumor microenvironment, and how MDSC may impact NK-cell-based immunotherapies. We also explore various strategies to increase NK cell cytotoxicity by blocking MDSC-mediated immunosuppression with the goal of enhancing cell based anti-cancer therapeutics.
27859 Maintenance of response through up to 5-years of continuous guselkumab treatment of psoriasis in the VOYAGE 2 phase 3 trial
Authors: Kristian Reich, April W. Armstrong, Richard Langley, Ron Vender, Peter Foley, Michael Song, Yin You, Yaung-Kaung Shen, Kenneth B. Gordon
Journal: Journal of the American Academy of Dermatology (2021)
Hematopoietic stem cell transplantation for Wiskott-Aldrich syndrome: an EBMT Inborn Errors Working Party analysis
Authors: Michael H. Albert, Mary A. Slatter, Andrew R. Gennery, Tayfun Güngör, Katerina Bakunina, Benyamin Markovitch, Sheree Hazelaar, Tiarlan Sirait, Virginie Courteille, Alessandro Aiuti, Olga V. Aleinikova, Dmitry Balashov, Maria Ester Bernardo, Ivana Bodova, Benedicte Bruno, Marina Cavazzana, Robert Chiesa, Alain Fischer, Fabian Hauck, Marianne Ifversen, Krzysztof Kałwak, Christoph Klein, Alexander Kulagin, Alphan Kupesiz, Baris Kuskonmaz, Caroline A. Lindemans, Franco Locatelli, Su Han Lum, Alexey Maschan, Roland Meisel, Despina Moshous, Fulvio Porta, Martin G. Sauer, Petr Sedlacek, Ansgar Schulz, Felipe Suarez, Tanja C. Vallée, Jacek H. Winiarski, Marco Zecca, Bénédicte Neven, Paul Veys, Arjan C. Lankester
Journal: Blood (2022)
2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines
Authors: Donna K. Arnett, Roger S. Blumenthal, Michelle A. Albert, Andrew B. Buroker, Zachary D. Goldberger, Ellen J. Hahn, Cheryl Dennison Himmelfarb, Amit Khera, Donald Lloyd-Jones, J. William McEvoy, Erin D. Michos, Michael D. Miedema, Daniel Muñoz, Sidney C. Smith, Salim S. Virani, Kim A. Williams, Joseph Yeboah, Boback Ziaeian
Journal: Circulation (2019)
<i>ACVR1</i> Mutations in DIPG: Lessons Learned from FOP
Authors: Kathryn R. Taylor, Maria Vinci, Alex N. Bullock, Chris Jones
Journal: Cancer Research (2014)

Whole-genome sequencing studies have recently identified a quarter of cases of the rare childhood brainstem tumor diffuse intrinsic pontine glioma to harbor somatic mutations in ACVR1. This gene encodes the type I bone morphogenic protein receptor ALK2, with the residues affected identical to those that, when mutated in the germline, give rise to the congenital malformation syndrome fibrodysplasia ossificans progressiva (FOP), resulting in the transformation of soft tissue into bone. This unexpected link points toward the importance of developmental biology processes in tumorigenesis and provides an extensive experience in mechanistic understanding and drug development hard-won by FOP researchers to pediatric neurooncology. Here, we review the literature in both fields and identify potential areas for collaboration and rapid advancement for patients of both diseases.
From the Food and Drug Administration
Authors: Stuart L. Nightingale
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Guarding the guardians: research on editorial peer review. Selected proceedings from the First International Congress on Peer Review in Biomedical Publication. May 10-12, 1989, Chicago, Ill
Authors: Drummond Rennie
Journal: JAMA (1990)

In May 1989, the American Medical Association sponsored The First International Congress on Peer Review in Biomedical Publication. This issue of<i>JAMA</i>is dedicated to papers first presented at that congress, themselves greatly modified by editorial peer review. We at<i>JAMA</i>, considering that publication lies at the heart of the scientific process and that at the heart of publication lies peer review,<sup>1</sup>were impressed by the evident lack of research<sup>2</sup>into a process that occupies our energies daily and on which we, as editors, are disposed to rely heavily. We recognized that the vast majority of papers written about editorial peer review had been composed in the absence of any data and were editorial effusions that expressed individual biases. Scientific investigations in this field were woefully lacking, and we set out to change this state of affairs.<sup>3</sup> Our objectives in holding the congress were simple: to stimulate
Compensation for Vaccine-Related Injuries
Journal: Annals of Internal Medicine (1984)

commercial product.This has led the courts to find ways of compensating the injured vaccinee within the limits of the judicial approach.Thus, the "duty to warn" derives from product liability for unavoidably dangerous but socially useful products, where vaccines are viewed in the same manner as, for example, dynamite.And "informed consent" originates in the theory of battery, where harm results from an unconsented touching, as, for example, between agreeing to participate in a boxing match and being mugged.Currently, uncertainty over fulfilling the legal duties of an adequate warning of potential risks and of obtaining "informed consent" to proceed with vaccination have led to: (1) concern by vaccine manufacturers over their liability, reflected in difficulty in insuring against such risks and decreased numbers of manufacturers involved in vaccine research and production, and (2) difficulties in trying to achieve a balance between giving vaccinees adequate information on the risks of vaccination and scaring them into not being vaccinated at all.How to insure against the risks and how to obtain informed consent have drawn most of the attention in efforts to address the problem of vaccine-related injuries and have obscured the primary reason for addressing that problem -public immunization programs are designed to protect not only the individual vaccinee but also those who are not vaccinated.Thus, when the vaccinee is harmed instead of protected, society has the obligation to minimize the consequences of injury.California and several countries have, in varying degrees, taken such steps to minimize those consequences.(see Chapter VI).Generally, these compensation programs consist of the following elements: (1) the vaccines to be covered, (2) the injuries to be included, (3) the kinds of compensation, (4) the administrative mechanisms, and (5) the relationships with existing compensation programs (lawsuits, social insurance).
Evaluating Long-term Efficacy of Neoadjuvant Chemoradiotherapy Plus Surgery for the Treatment of Locally Advanced Esophageal Squamous Cell Carcinoma
Authors: Ryan Sun, Lu Tian, Lee-Jen Wei
Journal: JAMA Surgery (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue
OPIUM HABIT IN CHILDREN.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Consequences of Inaccurate Assumptions in Coronary Stent Noninferiority Trials
Authors: Matheus Simonato, Ori Ben-Yehuda, Flavien Vincent, Zixuan Zhang, Björn Redfors
Journal: JAMA Cardiology (2022)

<h3>Importance</h3> The outcome and interpretation of noninferiority trials depend on the magnitude of the noninferiority margin and whether a relative or absolute noninferiority margin is used and may be affected by imprecision in event rate estimation. <h3>Objective</h3> To assess the consequence of imprecise event rate estimations on interpretation of peer-reviewed randomized clinical trials. <h3>Data Sources</h3> PubMed/MEDLINE was searched for articles published between January 1, 2015, and April 30, 2021. <h3>Study Selection</h3> Noninferiority randomized clinical trials of coronary stents published in selected journals with clinical events as the primary end point. <h3>Data Extraction and Synthesis</h3> Two reviewers (M.S. and F.V.) independently extracted data on trial characteristics, noninferiority assumptions, primary end point clinical outcomes, and study conclusions. Overestimation or underestimation of the control event rate was evaluated by dividing the assumed control event rate by the observed control event rate. For noninferiority end points with absolute margins, the assumed corresponding relative margin was defined as the ratio of the absolute margin and the assumed event rate, and the observed corresponding relative margin as the ratio between the absolute margin and the observed event rate in the control arm. Noninferiority comparisons with absolute margins were reanalyzed using the assumed corresponding relative margin and the Farrington-Manning score test for relative risk. <h3>Main Outcomes and Measures</h3> Overestimation or underestimation, assumed and observed corresponding relative margins, and relative reanalysis of the primary end points of trials with absolute margins. <h3>Results</h3> A total of 106 989 patients from 58 trials were included. The event rate in the control arms was overestimated by a median (IQR) of 28% (2%-74%). Most noninferiority trials used absolute rather than relative margins (55 of 58 trials [94.8%]). Owing to overestimation, absolute noninferiority margins became more permissive than originally assumed (median [IQR] of observed relative noninferiority margin, 1.62 [1.50-1.80] vs assumed relative noninferiority margin, 1.47 [1.39-1.55];<i>P</i> &lt; .001). Among trial comparisons that met noninferiority with an absolute noninferiority margin, 17 of 50 trials (34.0%) would not have met noninferiority with a corresponding assumed relative noninferiority margin. <h3>Conclusions and Relevance</h3> In this systematic review and meta-analysis, assumed event rates were often overestimated in noninferiority coronary stent trials. Because most of these trials use absolute margins to define noninferiority, such overestimation results in excessively permissive relative noninferiority margins.
AGAMEMNON: an Accurate metaGenomics And MEtatranscriptoMics quaNtificatiON analysis suite
Authors: Giorgos Skoufos, Fatemeh Almodaresi, Mohsen Zakeri, Joseph N. Paulson, Rob Patro, Artemis G. Hatzigeorgiou, Ioannis S. Vlachos
Journal: Genome biology (2022)

We introduce AGAMEMNON ( https://github.com/ivlachos/agamemnon ) for the acquisition of microbial abundances from shotgun metagenomics and metatranscriptomic samples, single-microbe sequencing experiments, or sequenced host samples. AGAMEMNON delivers accurate abundances at genus, species, and strain resolution. It incorporates a time and space-efficient indexing scheme for fast pattern matching, enabling indexing and analysis of vast datasets with widely available computational resources. Host-specific modules provide exceptional accuracy for microbial abundance quantification from tissue RNA/DNA sequencing, enabling the expansion of experiments lacking metagenomic/metatranscriptomic analyses. AGAMEMNON provides an R-Shiny application, permitting performance of investigations and visualizations from a graphics interface.
WATCH IT, LIFE
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Optimizing the diagnostic workflow for acute lymphoblastic leukemia by optical genome mapping
Authors: Katrina Rack, Jolien De Bie, Geneviève Ameye, Olga Gielen, Sofie Demeyer, Jan Cools, Kim De Keersmaecker, Joris R. Vermeesch, Johan Maertens, Heidi Segers, Lucienne Michaux, Barbara Dewaele
Journal: American Journal of Hematology (2022)

Acute lymphoblastic leukemia (ALL) is a malignancy that can be subdivided into distinct entities based on clinical, immunophenotypic and genomic features, including mutations, structural variants (SVs), and copy number alterations (CNA). Chromosome banding analysis (CBA) and Fluorescent In-Situ Hybridization (FISH) together with Multiple Ligation-dependent Probe Amplification (MLPA), array and PCR-based methods form the backbone of routine diagnostics. This approach is labor-intensive, time-consuming and costly. New molecular technologies now exist that can detect SVs and CNAs in one test. Here we apply one such technology, optical genome mapping (OGM), to the diagnostic work-up of 41 ALL cases. Compared to our standard testing pathway, OGM identified all recurrent CNAs and SVs as well as additional recurrent SVs and the resulting fusion genes. Based on the genomic profile obtained by OGM, 32 patients could be assigned to one of the major cytogenetic risk groups compared to 23 with the standard approach. The latter identified 24/34 recurrent chromosomal abnormalities, while OGM identified 33/34, misinterpreting only 1 case with low hypodiploidy. The results of MLPA were concordant in 100% of cases. Overall, there was excellent concordance between the results. OGM increased the detection rate and cytogenetic resolution, and abrogated the need for cascade testing, resulting in reduced turnaround times. OGM also provided opportunities for better patient stratification and accurate treatment options. However, for comprehensive cytogenomic testing, OGM still needs to be complemented with CBA or SNP-array to detect ploidy changes and with BCR::ABL1 FISH to assign patients as soon as possible to targeted therapy.