tbuckley/cabot-search huggingface dataset:
Pfizer-BioNTech and Oxford AstraZeneca COVID-19 vaccine effectiveness and immune response amongst individuals in clinical risk groups
Authors: Heather J Whitaker, Ruby S M Tsang, Rachel Byford, Nick J Andrews, Julian Sherlock, Praveen Sebastian Pillai, John Williams, Elizabeth Button, Helen Campbell, Mary Sinnathamby, William Victor, Sneha Anand, Ezra Linley, Jacqueline Hewson, Silvia DArchangelo, Ashley D Otter, Joanna Ellis, Richard F D Hobbs, Gary Howsam, Maria Zambon, Mary Ramsay, Kevin E Brown, Simon de Lusignan, Gayatri Amirthalingam, Jamie Lopez Bernal
Journal: Journal of Infection (2022)
Error in Author Name and Change to Open Access
Authors: Alexander Merkler, Cenai Zhang, Babak Navi
Journal: JAMA Neurology (2021)

Tanya Simuni, MD; Brian Fiske, PhD; Kalpana Merchant, PhD; Christopher S. Coffey, PhD; Elizabeth Klingner, MS; Chelsea Caspell-Garcia, MS; David-Erick Lafontant, MS; Helen Matthews; Richard K. Wyse, MD; Patrik Brundin, MD; David K. Simon, MD; Michael Schwarzschild, MD; David Weiner, MD; Jamie Adams, MD; Charles Venuto, PharmD; Ted M. Dawson, MD; Liana Baker, MS; Melissa Kostrzebski, MS; Tina Ward; Gary Rafaloff, MS; Parkinson Study Group NILO-PD Investigators and Collaborators; Jamie Adams; Erika Augustine; Deborah Baker; Alicia Brocht; Cindy Casaceli; Ken Eaton; Sue Henderson; Nichole McMullen; Phounsavath Muneath; Laura Trusso; Carlinda Field; Saurav Brahmachari ; Liana Rosenthal; Emily Carman; Cornelia Kamp; Patrick Bolger; Claire Wegel; Holly Reynolds; Oren Levy; Amber Servi; Kelvin Chou; Angela S Stovall; Gian Pal; Kellie Keith; Kathryn Chung; Joohi Shahed; Christine Hunter; Binit Shah; Katie Sullivan; Albert Y. Hung; Grace Bwala; Meredith Spindler; Alexandria Oliver; Robert A. Hauser; Claudia Rocha; Eric Molho; Sharon Evans; Holly A. Shill; Farah Ismail; Natividad Stover; Candace Cromer; Courtney Blair; Lin Zhang; Olga Kishchenko; Matthew Swan; Laura Ramirez; Samuel Frank; Stephanie Burrows; Andrew Duker; Christina Gruenwald; Karen Blindauer; Lynn Wheeler; Lauren Seeberger; Abigail Simpson; Burton L. Scott; Lisa Gauger; Anwar Ahmed; Yvette Pitchford; Jennifer Mule; Adolfo Ramirez-Zamora; Derek B. Ridgeway; John Slevin Slevin; Renee Wagner Wagner; Vanessa Hinson; Shonna Jenkins; John L. Goudreau; Doozie Russell; Zoltan Mari; Lilliana Dumitrescu; Jason Aldred; Melissa Bixby; Mark LeDoux
History
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Figure.
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE PROPOSED REORGANIZATION OF THE ARMY MEDICAL DEPARTMENT.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neoadjuvant nivolumab plus ipilimumab and adjuvant nivolumab in patients (pts) with localized microsatellite instability-high (MSI)/mismatch repair deficient (dMMR) oeso-gastric adenocarcinoma (OGA): The GERCOR NEONIPIGA phase II study.
Authors: Thierry Andre, David Tougeron, Guillaume Piessen, Christelle De La Fouchardiere, Christophe Louvet, Antoine Adenis, Marine Jary, Christophe Tournigand, Thomas Aparicio, Jérôme Desrame, Astrid Lièvre, Marie-Line Garcia-Larnicol, Thomas Pudlarz, Julie Henriques, Romain Cohen, Jérémie Lefevre, Magali Svrcek
Journal: Journal of Clinical Oncology (2022)

244 Background: In pts with resectable gastric adenocarcinoma or OGA, radical surgery is the only curative option and perioperative chemotherapy seems worthless for those with MSI/dMMR tumors. Methods: We conducted phase II study evaluating the efficacy of neo-adjuvant nivolumab and ipilimumab followed by adjuvant nivolumab in pts with resectable MSI/dMMR, T2-T4 NxM0 tumors. Treatment consisted of nivolumab 240 mg every 2 weeks (6 infusions) and ipilimumab 1 mg/kg every 6 weeks (2 infusions), followed by radical surgery 5 weeks (±1 week) after last injection of nivolumab. Pts with Becker tumor regression grade (TRG) &lt; 3 were treated with adjuvant nivolumab 480 mg every 4 weeks (9 infusions). The primary objective was pathological complete response (pCR) rate. Results: From 10/2019 to 06/2021, a total of 32 pts were enrolled (all had dMMR±MSI-H status; 16 with gastric cancer and 16 with OGA). The median age was 65.5 years (range, 40-80). Initial stage was: usT3Nx = 22, usT2Nx = 4, and usTxNx = 6 (not evaluable by ultrasound endoscopy). At data lock, 32 pts had terminated neo-adjuvant period and 27 (84%) completed all 6 neo-adjuvant cycles. 8 pts (32%) experienced G3/4 adverse events (AEs) during neo-adjuvant treatment. 29 pts underwent surgery; 2 refused surgery and had complete endoscopic response with tumor-free biopsies, 1 had surgery not performed in relation with a metastatic progression. The median delay between last injection and surgery was 35 days (extreme, 25-170). Overall surgical morbidity (54%, n = 14) was related to: anastomotic leakage = 4, pancreatitis = 2, pneumonia = 2, and other = 6. The incidence of post-operative mortality was 3.8% (n = 1) due to cardiovascular AE at post-operative day 3. All the 29 pts who underwent surgery had R0 resection: 17 (59%) had pCR (i.e., TRG 1a as per Becker grade, ypT0N0) and 4 (14%) had TRG 1b as per Beker grade (&lt; 10% residual tumor per tumor bed). 1 pt had TRG 2 (10-50% of residual tumor) and 7 pts had TRG 3 (˃50% of residual tumor) as per Becker grade, per local pathological assessment (central pathological review is awaited). With a median follow-up of 10.9 months, 1 pt had metastatic relapse, 1 pt died without relapse and 30 pts were recurrence/progression-free. Conclusions: Neo-adjuvant therapy with nivolumab and ipilimumab is feasible and is associated with a high pCR rate in pts with MSI/dMMR resectable OGA. Data will be updated for the congress. Clinical trial information: NCT04006262.
Separate and combined effects of hormone replacement and simvastatin 10 mg on lipoprotein (a) and lipoprotein subfractions in postmenopausal women with hypercholesterolemia Kevin C. Maki, Michael H. Davidson, Joanne Palmisano, Armando Susmano, Adrian Dobs, Irwin Kerber, Donald Hunninghake, Robert Knopp, Anne Goldberg, James McKenney, Peter Kakavas, David Waters, Neville Bittar. Chicago Center for Clinical Research, Chicago, IL, Merck &amp; Co, Inc., West Point, PA
Journal: Journal of the American College of Cardiology (2001)
Actionable Genetic Features of Primary Testicular and Primary Central Nervous System Lymphomas
Authors: Bjoern Chapuy, Margaretha GM Roemer, Yuxiang Tan, Chip Stewart, Liye Zhang, Andrew J Dunford, Ekaterina S Jordanova, Friedrich Feuerhake, Gerald Illerhaus, Daniel Gusenleitner, Erica Linden, Heather H Sun, Miyuki Aono, Gordon J Freeman, Todd R Golub, Gad Getz, Scott J. Rodig, Daphne de Jong, Stefano Monti, Margaret A. Shipp
Journal: Blood (2014)
Singling out how genes are regulated during development
Authors: Shawn M. Burgess
Journal: Cell Genomics (2022)

In this issue of Cell Genomics, McGarvey et al. characterize chromatin accessibility and gene regulation at single-cell resolution in the zebrafish embryo 24 h after fertilization, providing a valuable resource. Their findings add another important piece to understanding the dynamic landscape of gene expression and regulation during early vertebrate development and hint at the dramatic changes single-cell genomics is bringing to the field of developmental biology.
Correction to Lancet Infect Dis 2021; published online Jan 21. https://doi.org/10.1016/S1473-3099(20)30942-7
Journal: The Lancet Infectious Diseases (2021)

this Correspondence, the second sentence of the third paragraph should be "As of the end of January, 2021, the spread of N501Y, B.1.1.7 variants has been detected in SARS-CoV-2 isolate genomes from nearly 60 additional countries using CovMT (appendix)."This correction has been made to the online version as of March 1, 2021, and will be made to the printed version.
The Code—Another Reply to Amicus Veritatis.
Authors: None S. A. C.
Journal: JAMA (1895)

Canton, Ohio, Sept. 11, 1895. <h3>To the Editor:</h3> —The gentleman writing the open letter to you and signing himself<i>Amicus Veritatis</i>, reminds me of a ship at sea without a rudder, or a man out on the sea of professional life without a conscience, roaming about seeking whom or what he may devour from a non-professional or commercial standpoint. If the writer were to take up the Code and be determined to read and understand it in the same spirit as it was given us, in accordance with the Golden Rule, he would, I am sure, entertain a more exalted opinion of our profession. I read the communication very carefully, and laid it aside with a silent expression of pity for the writer. Respectfully,
Heating effects of magnetic resonance imaging of the brain on pacemaker leads: Send/receive coils versus receive-only coils Roger Luechinger, Firat Duru, Volkert A. Zeijlemaker, Markus B. Scheidegger, Reto Candinas, Peter Boesiger. Cardia Arrhythmia Unit, University Hospital Zurich, Zurich, Switzerland, Institute of Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland
Journal: Journal of the American College of Cardiology (2001)
Improvement of left ventricular remodeling and function by HMG-CoA reductase inhibition with cerivastatin in rats with heart failure after myocardial infarction Johann Bauersachs, Daniela Fraccarollo, Paolo Galuppo, Michael Christ, Georg Ertl. Medizinische Universitaetsklinik, Wuerzburg, Germany
Journal: Journal of the American College of Cardiology (2001)
Acute late occlusion after angioplasty of the lower limb arteries in patients receiving stent and brachytherapy: The need for more intense and prolonged antithrombotic prevention Andreas Blatter, Michael Llamas, Agostino Faggiotto, Jeanne-Marie Segatto, Mario Alerci, Kurt Jaeger, Felix Mahler, Augusto F. Gallino. Augusto Gallino, Bellinzona, Switzerland
Journal: Journal of the American College of Cardiology (2001)
C-reactive protein and ST segment monitoring with Continuous 12-lead electrocardiogram in patients with unstable angina Alexander Stefanidis, Michael Zairis, Stavros Manousakis, Evangelos Tsanis, Thomas Matsikas, Maria Thoma, John Hadjissavas, Apostolos Papantonakos, Stelios Handanis, Kostas Katsaros, Spyros Argyrakis, Stefanos Foussas. Cardiology Department, Tzanio Hospital, Piraeus, Greece
Journal: Journal of the American College of Cardiology (2001)
Grade 3 ischemia on presentation in acute myocardial infarction predicts rapid progression of necrosis and less myocardial salvage with thrombolytic therapy Yochai Birnbaum, Douglas A. Criger, Kathy B. Gates, Alejandro Barbagelata, Peter Clemmensen, Elena B. Sgarbossa, Raymond J. Gibbons, Galen S. Wagner. Rabin Medical Center, Petah Tiqva, Israel, Duke Clinical Research Institute, Durham, NC
Journal: Journal of the American College of Cardiology (2001)
<i>The Johns Hopkins Hospital Reports.</i>—Report in Pathology, II and III. Baltimore, The Johns Hopkins Press, 1892-3. Of these reports, No. 1 contains articles on the Papillomatous Tumors of the Ovary and Tuberculosis of the Female Generative Organs, both by Williams; No. 2, articles on Multiple Lympho-Sarcomata, by Flexner, on the Cerebellar Cortex of the Dog, by Berkley, a case of Chronic Nephritis in a Cow, by Councilman, Bacteria in their Relations to Vegetable Tissue, by Russell, and …
Journal: American Journal of Psychiatry (1893)
AMA-RPS Acts on Residents' Concerns
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intratumor expanded T cell clones can be non-sentinel lymph node derived in breast cancer revealed by single-cell immune profiling
Authors: Shiping Jiao, Qing Xiong, Meisi Yan, Xiaolu Zhan, Zhenhuang Yang, Cheng Peng, Beicheng Sun, Da Pang, Tong Liu
Journal: Journal for ImmunoTherapy of Cancer (2022)

Background Sentinel lymph nodes (LNs) are regarded as key immune surveillance sites in cancer wherein mature dendritic cells present tumor-derived antigens to prime and activate T cells, which then migrate to the tumor site. However, it is unclear whether the tumor-specific T cells can be elicited within the tumor independent of the sentinel LNs. Methods We performed an integrative analysis of gene expression profiles of 65,285 cells and T cell receptor sequences of 15,831 T cells from 5 paired primary breast tumors and sentinel LNs to identify where clonal T cells come from and the characteristics of those clonal T cells. Results The proportion of clonal T cells was higher in the primary tumors compared with the sentinel LNs, whereas all expanded clones identified in the sentinel LN were also present in the primary tumors. In contrast, 10.91% of the expanded clones in the primary tumors were not found in the sentinel LNs. These novel intratumoral T cell clones were characterized by high tissues retention capacity (CXCR6 +ITGAE+) and a distinct coinhibitory pattern (CD39 +NKG2A+) compared with the expanded T cell clones common to both sites. Furthermore, multiplex immunofluorescence imaging showed the presence of tertiary lymphoid structures (TLS) in the primary breast tumors wherein the activated cytolytic T cells were concentrated, indicating its possible role in eliciting non-sentinel LN-derived T cell clones. Conclusions Our study revealed expanded intratumor non-sentinel LN derived T cell clones located in the TLS, which points to the need for exploring the role of TLS in antitumor immunity.
Abstract P107: Leucocyte Telomere Length and Cardiovascular Disease in the Jackson Heart Study
Authors: Stanford Mwasongwe, Laura Raffield, Yan Gao, James G Wilson, Abraham Aviv, Alexander P Reiner
Journal: Circulation (2017)

Background: In European descent populations, shorter leucocyte telomere length (LTL) has been associated with clinical and subclinical atherosclerosis, while longer LTL has been associated with greater left ventricular hypertrophy (LVH). We evaluated the relationship of LTL with subclinical indices of cardiovascular disease (CVD) (coronary artery calcification [CAC], abdominal aorta calcification [AAC], carotid intima media thickness [CIMT], left ventricular mass [LVM], and ankle-brachial index [ABI]) in African Americans (AAs). We also examined whether LTL is associated with CVD events and mortality. Methods: Analyses included participants of the Jackson Heart Study (JHS), a prospective cohort study of AAs, with LTL data (n=2,573) measured by Southern blot analysis in DNA from the baseline exam (2000-2004). Adjudicated CVD events (coronary heart disease [CHD], heart failure [HF] and stroke) and mortality were identified through December 2012. Relationships were assessed using linear, logistic regression models, or Tobit model (CAC and AAC due to left censoring) in STATA 14. Results: In an age and sex adjusted model, longer LTL was significantly associated with lower CAC ( P =0.049, β=-0.535; 95% confidence interval [CI], -1.066,-0.003); this association was no longer significant after adjusting for body mass index, current smoking and other CVD risk factors. There were no significant associations between LTL and AAC, CIMT, or LVM. LTL was associated with higher ABI ( P =0.017, β=0.023; 95% CI, 0.004, 0.042) when the highest was compared to the lowest LTL quartile in models adjusted for CVD risk factors. After a median follow-up of 9 years, longer LTL was associated with lower risk of incident ischemic stroke and total mortality in age and sex adjusted models, but these associations were no longer significant in models fully adjusted for CVD risk factors. Conclusions: In conclusion, among a community-based cohort of AAs, LTL was associated with increased ABI, indicative of increased risk of peripheral arterial disease, but there were no significant associations with other CVD indices and mortality after adjustment for established risk factors.
UPON THE EXISTENCE OF A MINUTE MICRO-ORGANISM IN CASES OF CIRRHOSIS OF THE LIVER.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Circulating Metabolome and White Matter Hyperintensities in Women and Men
Authors: Eeva Sliz, Jean Shin, Shahzad Ahmad, Dylan M. Williams, Stefan Frenzel, Friederike Gauß, Sarah E. Harris, Ann-Kristin Henning, Maria Valdes Hernandez, Yi-Han Hu, Beatriz Jiménez, Muralidharan Sargurupremraj, Carole Sudre, Ruiqi Wang, Katharina Wittfeld, Qiong Yang, Joanna M. Wardlaw, Henry Völzke, Meike W. Vernooij, Jonathan M. Schott, Marcus Richards, Petroula Proitsi, Matthias Nauck, Matthew R. Lewis, Lenore Launer, Norbert Hosten, Hans J. Grabe, Mohsen Ghanbari, Ian J. Deary, Simon R. Cox, Nishi Chaturvedi, Josephine Barnes, Jerome I. Rotter, Stephanie Debette, M. Arfan Ikram, Myriam Fornage, Tomas Paus, Sudha Seshadri, Zdenka Pausova
Journal: Circulation (2022)

White matter hyperintensities (WMH), identified on T2-weighted magnetic resonance images of the human brain as areas of enhanced brightness, are a major risk factor of stroke, dementia, and death. There are no large-scale studies testing associations between WMH and circulating metabolites.