tbuckley/cabot-search huggingface dataset:
Eectrophysiological observations in pateints with rate dependent bundle branch block.
Authors: PDenes, DWu, R CDhingra, FAmat-y-leon, CWyndham, K MRosen
Journal: Circulation (1975)

Electrophysiological studies were conducted in 15 patients with tachycardic rate dependent bundle branch block (RDBBB): ten with left, and five with right. No bradycardic RDBBB was observed, despite occurrence of cycle lengths (CL) longer than 1200 msec in over half the patients studied. Onset of RDBBB was abrupt in 13 patients, and gradual in two. In three patients, the CL allowing reversion to normal conduction (once RDBBB was initiated) was 50, 55, and 190 msec longer, respectively, than the CL inducing RDBBB. Bundle brance refractory periods (RP) were measured with atrial extrastimulus technique in five patients. All RP (except one) were prolonged at all tested CL when compared to patients without conduction disease. The expected decrease in RP with shortening of CL did not occur in four of the five patients. The electrophysiological abnormality in patients with DBBB thus appeared to be an increase in refractoriness in the affected bundle branch, along with a loss of the normal decrease in refractorin...
Differences in the electrophysiological response of canine ventricular epicardium and endocardium to ischemia. Role of the transient outward current.
Authors: ALukas, CAntzelevitch
Journal: Circulation (1993)

BACKGROUNDAcute ischemia is known to produce more severe electrophysiological disturbances in canine ventricular epicardium than endocardium, although the mechanism for the differential sensitivity is still unresolved. Recent studies have demonstrated the presence of a prominent transient outward current (Ito) in ventricular epicardium but not endocardium. The present study was designed to test the hypothesis that the differential sensitivity of these two tissues to ischemia results, at least in part, from a more prominent Ito in epicardium than in endocardium.METHODS AND RESULTSIsolated canine ventricular epicardial and endocardial tissues and myocytes were studied by standard microelectrode techniques. Simulated ischemia (hyperkalemia, hypoxia, and acidosis) abolished the action potential plateau and caused a 50% to 60% shortening of action potential duration in epicardium but only a 10% to 20% shortening in endocardium. 4-Aminopyridine, an Ito inhibitor, restored the plateau in epicardium and reduced t...
131P Predictive factors of response to PD-(L)1 inhibitors in patients with advanced non-small cell lung (NSCLC) and high PD-L1 expression
Authors: A. Barba Ioaquín, A. Piedra, J. Mosquera, M. Riudavets, M.I. Gomez-Randulfe, M.R. Garcia Campelo, I.G. Sullivan, J. Serra, M. Aguado, M. Majem Tarruella
Journal: Journal of Thoracic Oncology (2021)
Efficacy of permanent pacing in the management of high-risk patients with long QT syndrome.
Authors: A JMoss, J ELiu, SGottlieb, E HLocati, P JSchwartz, J LRobinson
Journal: Circulation (1991)

BACKGROUNDFrom the international long QT syndrome (LQTS) study, 30 patients with corrected QT interval (QTc) of more than 0.44 second 1/2 were identified who had permanent pacemakers implanted for management of recurrent syncope or aborted cardiac arrest.METHODS AND RESULTSPacemakers were implanted on average 7 years after the onset of the first syncopal episode. Most of the patients were female (87%), the average age at implantation was 19 +/- 13 years, the mean QTc was 0.55 +/- 0.08 second, and 57% were receiving antiadrenergic treatment for LQTS when the pacemaker was placed. Using birth as the time origin, the median cardiac event rate was significantly (p less than 0.001) reduced by pacing from 0.5 to 0 events per patient per year, with 21 patients experiencing no cardiac events during an average pacemaker follow-up of 49 months per patient. In 10 patients in whom the demand atrial pacing rate was faster than the intrinsic sinus rate, the average heart rate was increased 23 beats/min (from 58 to 81 b...
Dicrotic pulse after open heart surgery.
Authors: R COrchard, ECraige
Journal: Circulation (1980)

Pre- and postoperative echophonocardiograms (EPCGs) and preoperative hemodynamic data of 108 patients who underwent valve replacement were reviewed to establish the frequency and significance of a dicrotic pulse (DP) postoperatively. DP occurred almost exclusively in patients who underwent valve replacement for regurgitant lesions (20 of 28 with aortic regurgitation, nine of 25 with mitral regurgitation, and four of six with both aortic and mitral regurgitation). These patients were divided into dicrotic and nondicrotic groups. Preoperatively, the dicrotic group had significantly larger end-diastolic volumes (p < 0.01) and end-systolic volumes (p < 0.01) and significantly lower ejection fractions (p < 0.01). Echocardiographically, the dicrotic group had larger left ventricular dimensions, both systolic (p < 0.01) and diastolic (p < 0.05), reduced percentage fractional shortening of the left ventricular cavity (p < 0.01) and poor thickening properties of the left ventricular posterior wall (% delta Th-LVPW...
M-mode echocardiography in the evaluation of patients for aneurysmectomy.
Authors: J CDillon, HFeigenbaum, A EWeyman, B CCorya, SPeskoe, SChang
Journal: Circulation (1976)

In order to determine whether echocardiography could be useful in predicting surgical mortality of aneurysmectomy, preoperative condensed M-mode echocardiographic scans were taken from both mid (standard position) and low (nearer apex) intercostal spaces and/or from the subxiphoid area in eighteen patients who were sent to surgery for aneurysmectomy. Eleven of the eighteen patients survived aneurysmectomy. All eleven had mid left ventricular dimensions less than 3.3 cm/m2 and low dimensions of 3.8 cm/m2 or less. Of the seven patients who died, the mid and low left ventricular dimensions exceeded 3.3 cm/m2 and 3.8 cm/m2, respectively, with one exception. The combination of abnormal mitral valve closure, a dilated mid dimension and lack of normal motion in opposing wall segments was only seen in six nonsurvivors. Echocardiography can provide information concerning the state of the left ventricle in patients with ventricular aneurysms and these findings may be helpful in predicting surgical mortality for ane...
Guidance for the design and reporting of studies evaluating the clinical performance of tests for present or past SARS-CoV-2 infection
Authors: Jenny A Doust, Katy J L Bell, Mariska M G Leeflang, Jacqueline Dinnes, Sally J Lord, Sue Mallett, Janneke H H M van de Wijgert, Sverre Sandberg, Khosrow Adeli, Jonathan J Deeks, Patrick M Bossuyt, Andrea R Horvath
Journal: BMJ (2021)

Testing for SARS-CoV-2 infection is key in managing the current pandemic. More than 1700 preprints and peer reviewed journal articles evaluating tests for SARS-CoV-2 infection have been published as of January 2021. However, evaluations of these studies have identified many methodological issues, leading to a high risk of bias and difficulties applying the results in practice. Better guidance is urgently needed on the conduct and interpretation of these studies. This article outlines the principles for defining the intended purpose of the test; study population selection; reference standard, test timing; and other critical considerations for the design, reporting, and interpretation of diagnostic accuracy studies. The implementation and accuracy of SARS-CoV-2 tests have major implications for individuals and communities, balancing the potential consequences of continued infection against the need for public health measures, such as the restriction of movements and social activities. Decision making in the current pandemic requires a clear understanding of the clinical performance and limitations of testing. This article provides guidance to assist researchers design robust diagnostic accuracy studies, assist publishers and peer reviewers to assess such studies, and support clinicians and policy makers in their evaluation of the evidence on SARS-CoV-2 testing for clinical and public health decisions. The guidance aims to ensure that studies evaluating the diagnostic accuracy of SARS-CoV-2 tests are conducted as rigorously as possible, in an efficient and timely way.
Insights on the structure–function relationship of human multidrug resistance protein 7 (MRP7/ABCC10) from molecular dynamics simulations and docking studies
Authors: Jing‐Quan Wang, Qingbin Cui, Zi‐Ning Lei, Qiu‐Xu Teng, Ning Ji, Lusheng Lin, Zhijun Liu, Zhe‐Sheng Chen
Journal: MedComm (2021)

Abstract ATP‐binding cassette (ABC) transporters superfamily mediates multidrug resistance in cancer by extruding structurally distinct chemotherapeutic agents, causing failure in chemotherapy. Among the 49 ABC transporters, multidrug resistance protein 7 (MRP7 or ABCC10) is relatively new and has been identified as the efflux pump of multiple anticancer agents including Vinca alkaloids and taxanes. Herein, we construct and validate a homology model for human MRP7 based on the cryo‐EM structures of MRP1. Structure–function relationship of MRP7 was obtained from molecular dynamics simulations and docking studies and was in accordance with previous studies of ABC transporters. The motion patterns correlated with efflux mechanism were discussed. Additionally, predicted substrate‐ and modulator‐binding sites of MRP7 were described for the first time, which provided rational insights in understanding the drug binding and functional regulation in MRP7. Our findings will benefit the high‐throughput virtual screening and development of MRP7 modulators in the future.
Effects of aging on mechanics and composition of cerebral arterioles in rats.
Authors: M AHajdu, D DHeistad, J ESiems, G LBaumbach
Journal: Circulation Research (1990)

The purpose of this study was to examine effects of aging on the mechanics and composition of cerebral arterioles. We measured pressure (servo-null) and diameter in pial arterioles in anesthetized adult (9-12 months old) and aged (24-27 months old) Fischer 344 rats. After deactivation of smooth muscle with EDTA, diameter of pial arterioles at 70 mm Hg pial arteriolar pressure was less in aged than in adult rats (67 +/- 4 vs. 81 +/- 4 microns [mean +/- SEM], p less than 0.05). The stress-strain relation and the slope of tangential elastic modulus versus stress (6.8 +/- 0.6 vs. 5.3 +/- 0.3, p less than 0.05) indicated that distensibility of pial arterioles was reduced in aged rats. Cross-sectional area of the vessel wall, measured histologically, was less in aged than adult rats (1,239 +/- 91 vs. 1,832 +/- 180 microns2, p less than 0.05). Point counting stereology was used to quantitate smooth muscle, elastin, collagen, and basement membrane in the arteriolar wall. Cross-sectional areas of smooth muscle and...
Endoscopic Papillectomy Vs. Pancreaticoduodenectomy for Ampullary Lesions: a Propensity-Scored Matching Analysis of the ESAP Study
Authors: M Hollenbach, C Heise, E Abou Ali, F Auriemma, A Gulla, S Regner, S Gaujoux
Journal: Endoscopy (2021)

Aims Ampullary lesions (AL) are a rare condition but may be clinically significant by obstruction, jaundice, bleeding or malignant transformation. Main resection techniques comprise the endoscopic papillectomy (EP), the surgical ampullectomy (SA) and pancreaticoduodenectomy (PD). Since consistent comparative data are lacking, we performed a retrospective multicenter center study (Endoscopic-Papillectomy-versus-Surgical-Ampullectomy-versus-Pancreaticoduodectomy (ESAP)) comparing the most frequent procedures, i.e. EP and PD.
Novel Supreme Drug-Eluting Stents With Early Synchronized Antiproliferative Drug Delivery to Inhibit Smooth Muscle Cell Proliferation After Drug-Eluting Stents Implantation in Coronary Artery Disease: Results of the PIONEER III Randomized Clinical Trial
Authors: Alexandra J. Lansky, Dean J. Kereiakes, Andreas Baumbach, Stephan Windecker, Yasin Hussain, Cody Pietras, Ovidiu Dressler, Ozgu Issever, Michael Curtis, Barry Bertolet, James P. Zidar, Pieter C. Smits, Victor Alfonso Jiménez Díaz, Brent McLaurin, Sjoerd Hofma, Ángel Cequier, Nabil Dib, Edouard Benit, Anthony Mathur, David Brogno, Jacques Berland, Joanna Wykrzykowska, Guy Piegari, Salvatore Brugaletta, Shigeru Saito, Martin B. Leon
Journal: Circulation (2021)

Accelerated endothelial healing after targeted antiproliferative drug delivery may limit the long-term inflammatory response of drug-eluting stents (DESs). The novel Supreme DES is designed to synchronize early drug delivery within 4 to 6 weeks of implantation, leaving behind a prohealing permanent base layer. Whether the Supreme DES is safe and effective in the short term and can improve long-term clinical outcomes is not known.In an international, 2:1 randomized, single-blind trial, we compared treatment with Supreme DES to durable polymer everolimus-eluting stents (DP-EES) in patients with acute and chronic coronary syndromes. The primary end point was target lesion failure-a composite of cardiac death, target vessel myocardial infarction, or clinically driven target lesion revascularization. The trial was designed to demonstrate noninferiority (margin of 3.58%) of the Supreme DES at 12 months compared with DP-EES (URL: https://www.clinicaltrials.gov; Unique identifier: NCT03168776).From October 2017 to July 2019, a total of 1629 patients were randomly assigned (2:1) to the Supreme DES (N=1086) or DP-EES (N=543). At 12 months, target lesion failure occurred in 57 of 1057 patients (5.4%) in the Supreme DES group and in 27 of 532 patients (5.1%) in the DP-EES group (absolute risk difference, 0.32% [95% CI, -1.87 to 2.5]; Pnoninferiority=0.002]. There were no significant differences in rates of device success, clinically driven target lesion revascularization, or stent thrombosis at 12 months, and the safety composite of cardiovascular death and target vessel myocardial infarction was 3.5% versus 4.6% (hazard ratio, 0.76 [95% CI, 0.46-1.25]) with Supreme DES compared with DP-EES, although rates of combined clinically and non-clinically driven target lesion revascularization at 12 months were higher with Supreme DES.Among patients with acute and chronic coronary syndromes undergoing percutaneous coronary intervention, the Supreme DES proved to be noninferior to the standard DP-EES. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03168776.
Two-dimensional echocardiographic features of right ventricular infarction.
Authors: BD'Arcy, N CNanda
Journal: Circulation (1982)

Real-time, two-dimensional echocardiographic studies were performed in 10 patients with acute myocardial infarction who had clinical features suggestive of right ventricular involvement. All patients showed right ventricular wall motion abnormalities. In the four-chamber view, seven patients showed akinesis of the entire right ventricular diaphragmatic wall and three showed akinesis of segments of the diaphragmatic wall. Segmental dyskinetic areas involving the right ventricular free wall were identified in four patients. One patient showed a large right ventricular apical aneurysm. Other echocardiographic features included enlargement of the right ventricle in eight cases, paradoxical ventricular septal motion in seven cases, tricuspid incompetence in eight cases, dilatation of the stomach in four cases and localized pericardial effusion in two cases. Right ventricular infarction was confirmed by radionuclide in seven patients, at surgery in one patient and at autopsy in two patients.
Arterial fibrous proteins in cynomolgus monkeys after atherogenic and regression diets.
Authors: M LArmstrong, M BMegan
Journal: Circulation Research (1975)

Fibrous proteins were measured in five arterial beds in adult cynomolgus monkeys after administration of atherogenic and regression regimens. Atherosclerosis was induced by feeding the monkeys a hypercholesterolemic diet containing 1.2% cholesterol for 17 months. A low-fat, cholesterol-free regression diet was then given for 60 days, 200 days, and 20 months. In atherosclerosis, collagen concentration (mg/g dry weight) and collagen content (mg/cm length of artery) both increased. At 200 days of regression the collagen concentration, but not the collagen content, was higher than it was in atherosclerosis. In late regression (20 months), the collagen content was lower than it was in atherosclerosis, although in the five arterial beds considered together the collagen concentration was not significantly lower. Both the elastin concentration and the elastin content rose in atherosclerosis and decreased in regression. These mass data suggest that fibrous proteins are lost from the arterial wall during a regressi...
Transcatheter occlusion of patent ductus arteriosus with adjustable buttoned device. Initial clinical experience.
Authors: P SRao, E BSideris, JHaddad, CRey, GHausdorf, A DWilson, P ASmith, P SChopra
Journal: Circulation (1993)

BACKGROUNDSeveral devices are available for transcatheter occlusion of patent ductus arteriosus. Most of these devices either require complicated intracardiac maneuvering, have not been tried in humans, or need a large-sized sheath for implantation of the device.METHODS AND RESULTSDuring a 26-month period ending November 1992, 14 patients underwent transcatheter closure of patent ductus arteriosus with an adjustable buttoned device delivered via a 7F sheath under an institutional review board-approved custom-made device protocol. The children were 15 months to 8 years of age with weight range of 7.2 to 19 kg. The patent ductus arteriosus measured from 2 to 7.5 mm (median, 3 mm) at the narrowest diameter and was conical, short, or tubular. They were occluded with devices measuring 15 to 20 mm. The ratio of pulmonary to systemic flow decreased (P < .01) from 1.9 +/- 0.6 (mean +/- SD; range, 1.3 to 3.2) to 1.05 +/- 0.1 (1 to 1.3). Continuous murmur of patent ductus arteriosus disappeared in all except 1 pati...
Adrenal suppression from high-dose inhaled fluticasone propionate in children with asthma
Authors: A. Mohn, M. Verini, R. Mele, C. De Leonardis, F. Chiarelli
Journal: European Respiratory Journal (2004)

and macrophages, and which is associated with coagulation and bacterial infiltration of the injured tissue.Finally, there is an endocrine or late phase characterised by proliferation with endothelium and vascular wall modelling (angiogenesis), which, in the case of healing, involves tissular regeneration or wound healing by scar formation [2][3][4].Therefore, in an early or nervous phase, the nutrition of the injured tissue would be produced by diffusion (oedema), a mechanism with low energetic requirement that does not require oxygen (ischemia) or that is not correctly used (synthesis of reactive oxygen species (ROS)).Products derived from the degradation of macromolecules by the ROS action can constitute substrates that reach the cells by diffusion.In the intermediate or immune phase, the nutrition could be mediated by the inflammatory cells because both the neutrophils, as well as the macrophages, have a large capacity for intracellular (phagocytosis of debris) and extracellular (release of enzymes) digestion [5,6].Complex proteins, such as enzymes and debris, can be important sources of fermentation [7].These inflammatory cells respond with respiratory burst and release high concentrations of superoxide anion radical, hydroxyl radical, hypochlorus acid, hypobromite and hydrogen peroxide [1].The lymphatic circulation could predominate in these phases of the inflammation in detriment of the blood circulation.Finally, in the late or endocrine phase, blood circulation is involved in the nutrition [5,6].Angiogenesis makes it possible to acquire a capillary network that is specialised in supplying oxygen and substrates to cells, which, in turn, use them through oxidative metabolism [6,8], thus producing regeneration.However, the wounds heal by scar formation, a process in which the fibroblasts, due to their phenotypic plasticity [9], could become intermediary cells of the epithelial nutrition.The deficient capacity of the fibroblasts for this trophic function could explain the defective quality of the epithelium obtained.Phases that are similar to the above-mentioned ones are commonly described in airway asthmatic inflammation [1,9].In this way, reactive oxygen species hyperproduction, whether by revascularisation or by reactive oxygen species release by the inflammatory cells during the respiratory burst, could represent primitive trophic mechanisms, which are used by the injured tissue when the use of oxygen by oxidative phosphorylation is not possible.More useful energy (adenosine triphosphate) can be generated through this latter pathway and it is a more elaborated trophic mechanism.
Capillary hydraulic conductivity is elevated by cGMP-dependent vasodilators.
Authors: D JMeyer, V HHuxley
Journal: Circulation Research (1992)

Microvascular functions have been shown to be sensitive to agents associated with changes in cyclic nucleotide levels. The central hypothesis of the current study was that one measure of capillary exchange capacity, hydraulic conductivity (Lp), would be elevated by agents shown to elevate cellular levels of cGMP. To evaluate the hypothesis, frog mesenteric capillary Lp was measured during luminal exposure to 1) atrial natriuretic peptide (ANP), 2) the truncated atriopeptins ANP-I and ANP-III, 3) the nitrovasodilator sodium nitroprusside (SNP), 4) the cGMP phosphodiesterase inhibitor MB 10 nM ANP induced a 2.1 +/- 0.3-fold change (n = 8), while 10 nM ANP-III elicited a 1.7 +/- 0.4-fold change (n = 8). In contrast, Lp did not change from basal levels during 10 nM ANP-I infusion (Lp ANP-I/Lp control = 1.2 +/- 0.2; n = 14). SNP (1 microM) induced a revers...
Lack of myocardial perfusion immediately after successful thrombolysis. A predictor of poor recovery of left ventricular function in anterior myocardial infarction.
Authors: HIto, TTomooka, NSakai, HYu, YHigashino, KFujii, TMasuyama, AKitabatake, TMinamino
Journal: Circulation (1992)

BACKGROUNDWe investigated myocardial perfusion dynamics after thrombolysis and its clinical implications.METHODS AND RESULTSWe studied 39 patients with acute anterior myocardial infarction (AMI). Myocardial contrast echocardiography (MCE) was performed before and immediately after successful reflow with intracoronary injection of sonicated Ioxaglate. The average segmental score by two-dimensional echocardiography (graded 0, normal, to 3, akinetic/dyskinetic) and global ejection fraction (left ventricular ejection fraction, LVEF%) by left ventriculography were measured at 1 day and at 4 weeks after reflow. Hypokinesis in the infarct region was assessed by the centerline method and expressed in terms of standard deviations (regional wall motion [RWM]: SD/chord) of normal. Immediately after reflow, 30 of 39 patients (group A) showed significant contrast enhancement within the risk area. The other nine patients (23%, group B), however, showed the residual contrast defect in the risk area (myocardial no reflow...
Efficacy and safety of timolol for prevention of supraventricular tachyarrhythmias after coronary artery bypass surgery.
Authors: H DWhite, E MAntman, M AGlynn, J JCollins, L HCohn, R JShemin, P LFriedman
Journal: Circulation (1984)

Forty-one patients undergoing coronary artery bypass grafting were randomly assigned to receive prophylactic timolol or placebo, given in a double-blind fashion. beta-Adrenoceptor-blocking therapy was stopped at least one half-life before surgery. Three to 7 hr after surgery (304 +/- 56 min), 0.5 mg of timolol or placebo was given intravenously twice daily in a double-blind manner. When oral medications were resumed postoperatively, 10 mg of timolol twice daily or placebo was continued orally. Continuous electrocardiograms were recorded for 24 hr before and for 7 days after surgery with a standard cassette recorder. No patient received digoxin. Both groups were comparable for frequency of preoperative supraventricular arrhythmias, left ventricular ejection fraction, duration of cardiopulmonary bypass, aortic cross-clamp time, number of bypass grafts, and total duration of monitoring. Analysis of arrhythmias was done by hand counts, and supraventricular arrhythmias were divided into supraventricular tachyc...