tbuckley/cabot-search huggingface dataset:
Death of a child and the risk of heart failure: a population‐based cohort study from Denmark and Sweden
Authors: Dang Wei, Jiong Li, Imre Janszky, Hua Chen, Fang Fang, Rickard Ljung, Krisztina D. László
Journal: European Journal of Heart Failure (2021)

We aimed to investigate whether the death of a child, one of the most severe stressors, is associated with the risk of heart failure (HF).We conducted a population-based cohort study involving parents of live-born children recorded in the Danish and Swedish Medical Birth Registers during 1973-2016 and 1973-2014, respectively (n = 6 717 349). We retrieved information on child death, HF diagnosis and sociodemographic characteristics of the parents from several nationwide registries. We performed Poisson regression models to estimate incidence rate ratios (IRR) and 95% confidence intervals (CI) for HF in relation to bereavement. A total of 129 829 (1.9%) parents lost at least one child during the follow-up. Bereaved parents had a 35% higher risk of HF than the non-bereaved (IRR 1.35, 95% CI 1.29-1.41; p < 0.001). The increased HF risk was observed not only when the child died due to cardiovascular or other natural causes, but also when the loss was due to unnatural causes. The association tended to be U-shaped when we categorized the exposed parents by the number of remaining live children at loss or by the age of the deceased child.We found that the death of a child was associated with an increased risk of HF. The finding that not only cardiovascular and other natural deaths, but also unnatural deaths were associated with HF suggests that stress-related mechanisms may contribute to the development of HF.
TCT-454 Complications and Failure Modes of Inari FlowTriever Aspiration System in Pulmonary Embolism: Insights From the MAUDE Database
Authors: Ramy Sedhom, Peter Abdelmaseeh, Magued Haroun, Michael Megaly, Mir Basir, Wissam Jaber
Journal: Journal of the American College of Cardiology (2021)
Pathobionts: mechanisms of survival, expansion, and interaction with host with a focus on <i>Clostridioides difficile</i>
Authors: Harish Chandra, Krishna Kant Sharma, Olli H. Tuovinen, Xingmin Sun, Pratyoosh Shukla
Journal: Gut Microbes (2021)

Pathobionts are opportunistic microbes that emerge as a result of perturbations in the healthy microbiome due to complex interactions of various genetic, exposomal, microbial, and host factors that lead to their selection and expansion. Their proliferations can aggravate inflammatory manifestations, trigger autoimmune diseases, and lead to severe life-threatening conditions. Current surge in microbiome research is unwinding these complex interplays between disease development and protection against pathobionts. This review summarizes the current knowledge of pathobiont emergence with a focus on Clostridioides difficile and the recent findings on the roles of immune cells such as iTreg cells, Th17 cells, innate lymphoid cells, and cytokines in protection against pathobionts. The review calls for adoption of innovative tools and cutting-edge technologies in clinical diagnostics and therapeutics to provide insights in identification and quantification of pathobionts.
Cold exposure protects from neuroinflammation through immunologic reprogramming
Authors: Martina Spiljar, Karin Steinbach, Dorothée Rigo, Nicolas Suárez-Zamorano, Ingrid Wagner, Noushin Hadadi, Ilena Vincenti, Nicolas Page, Bogna Klimek, Mary-Aude Rochat, Mario Kreutzfeldt, Claire Chevalier, Ozren Stojanović, Olivia Bejuy, Didier Colin, Matthias Mack, Dilay Cansever, Melanie Greter, Doron Merkler, Mirko Trajkovski
Journal: Cell Metabolism (2021)

Autoimmunity is energetically costly, but the impact of a metabolically active state on immunity and immune-mediated diseases is unclear. Ly6Chi monocytes are key effectors in CNS autoimmunity with an elusive role in priming naive autoreactive T cells. Here, we provide unbiased analysis of the immune changes in various compartments during cold exposure and show that this energetically costly stimulus markedly ameliorates active experimental autoimmune encephalomyelitis (EAE). Cold exposure decreases MHCII on monocytes at steady state and in various inflammatory mouse models and suppresses T cell priming and pathogenicity through the modulation of monocytes. Genetic or antibody-mediated monocyte depletion or adoptive transfer of Th1- or Th17-polarized cells for EAE abolishes the cold-induced effects on T cells or EAE, respectively. These findings provide a mechanistic link between environmental temperature and neuroinflammation and suggest competition between cold-induced metabolic adaptations and autoimmunity as energetic trade-off beneficial for the immune-mediated diseases.
TCT-306 Radiation Protection Cabin: A New Promise in Radiation Protection for the Interventional Cardiologist
Authors: Dolores Cañadas, Inmaculada Noval-Morillas, William Delgado-Nava, Livia L. Gheorghe, German Calle Perez, Alejandro Gutierrez-Barrios
Journal: Journal of the American College of Cardiology (2021)
Reply: Soluble VE-cadherin: not just a marker of endothelial permeability
Authors: Olfa Harki, Gilles Faury, Isabelle Vilgrain, Jean-Louis Pépin, Anne Briançon-Marjollet
Journal: European Respiratory Journal (2021)

<b>In relatively healthy OSA patients devoid of comorbidities, sVE could be related to early modifications of endothelial permeability without relation to inflammation, and may have an impact on endothelial cell physiology that could be further explored</b>https://bit.ly/3BURMA3
Comparative sensitivity evaluation for 122 CE-marked rapid diagnostic tests for SARS-CoV-2 antigen, Germany, September 2020 to April 2021
Authors: Heinrich Scheiblauer, Angela Filomena, Andreas Nitsche, Andreas Puyskens, Victor M Corman, Christian Drosten, Karin Zwirglmaier, Constanze Lange, Petra Emmerich, Michael Müller, Olivia Knauer, C Micha Nübling
Journal: Eurosurveillance (2021)

Introduction Numerous CE-marked SARS-CoV-2 antigen rapid diagnostic tests (Ag RDT) are offered in Europe, several of them with unconfirmed quality claims. Aim We performed an independent head-to-head evaluation of the sensitivity of SARS-CoV-2 Ag RDT offered in Germany. Methods We addressed the sensitivity of 122 Ag RDT in direct comparison using a common evaluation panel comprised of 50 specimens. Minimum sensitivity of 75% for panel specimens with a PCR quantification cycle (Cq) ≤ 25 was used to identify Ag RDT eligible for reimbursement in the German healthcare system. Results The sensitivity of different SARS-CoV-2 Ag RDT varied over a wide range. The sensitivity limit of 75% for panel members with Cq ≤ 25 was met by 96 of the 122 tests evaluated; 26 tests exhibited lower sensitivity, few of which failed completely. Some RDT exhibited high sensitivity, e.g. 97.5 % for Cq &lt; 30. Conclusions This comparative evaluation succeeded in distinguishing less sensitive from better performing Ag RDT. Most of the evaluated Ag RDT appeared to be suitable for fast identification of acute infections associated with high viral loads. Market access of SARS-CoV-2 Ag RDT should be based on minimal requirements for sensitivity and specificity.
Development of a magnetically aligned regenerative tissue-engineered electronic nerve interface for peripheral nerve applications
Authors: Mary Kasper, Bret Ellenbogen, Ryan Hardy, Madison Cydis, Jorge Mojica-Santiago, Abdullah Afridi, Benjamin S. Spearman, Ishita Singh, Cary A. Kuliasha, Eric Atkinson, Kevin J. Otto, Jack W. Judy, Carlos Rinaldi-Ramos, Christine E. Schmidt
Journal: Biomaterials (2021)
A cost-effectiveness study of universal screening for hepatitis C virus infection in South Korea: A societal perspective
Authors: Hye-Lin Kim, Kyung-Ah Kim, Gwang Hyun Choi, Eun Sun Jang, Moran Ki, Hwa Young Choi, Sook-Hyang Jeong
Journal: Clinical and Molecular Hepatology (2021)

This study aimed to evaluate the cost-effectiveness of hepatitis C virus (HCV) screening compared to no screening in the Korean population from societal and healthcare system perspectives.
It’s complicated: characterizing the time-varying relationship between cell phone mobility and COVID-19 spread in the US
Authors: Sean Jewell, Joseph Futoma, Lauren Hannah, Andrew C. Miller, Nicholas J. Foti, Emily B. Fox
Journal: npj Digital Medicine (2021)

Restricting in-person interactions is an important technique for limiting the spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Although early research found strong associations between cell phone mobility and infection spread during the initial outbreaks in the United States, it is unclear whether this relationship persists across locations and time. We propose an interpretable statistical model to identify spatiotemporal variation in the association between mobility and infection rates. Using 1 year of US county-level data, we found that sharp drops in mobility often coincided with declining infection rates in the most populous counties in spring 2020. However, the association varied considerably in other locations and across time. Our findings are sensitive to model flexibility, as more restrictive models average over local effects and mask much of the spatiotemporal variation. We conclude that mobility does not appear to be a reliable leading indicator of infection rates, which may have important policy implications.
TCT-346 The Mega COMBO Collaboration: An Individual Patient Data Pooled Analysis of Patients Undergoing PCI With COMBO Stent
Authors: Matteo Nardin, Carlo Andrea Pivato, Davide Cao, Zhongjie Zhang, Samantha Sartori, Johny Nicolas, Mauro Chiarito, Hanbo Qiu, Alexandre Abizaid, Evald Christiansen, Antonio Colombo, Robbert de Winter, Michael Haude, Lars Jakobsen, Lisette Okkels Jensen, Ulf Landmesser, Shigeru Saito, Harry Suryapranata, Giuseppe De Luca, George Dangas, Roxana Mehran
Journal: Journal of the American College of Cardiology (2021)
The Assessment of Bronchoalveolar Lavage (BAL) Fluid Composition in Critically Ill Patients with and Without COVID-19 and AKI
Authors: Nay Seif, Richard G. Wunderink, Anand Srivastava, Pinelopi P. Kapitsinou
Journal: Journal of the American Society of Nephrology (2021)

Seif, Nay; Wunderink, Richard G.; Srivastava, Anand; Kapitsinou, Pinelopi P. Author Information
Left Bundle Branch Block Induced by Transcatheter Aortic Valve Implantation Increases Risk for 1-Year All-Cause Mortality
Authors: L.A. van Garsse, P. Houthuizen, T.T. Poels, B.M. Swinkels, J.M. ten Berg, F. van der Kley, M.J. Schalij, J. Baan, R. Cocchieri, G.R. Brueren, B.H. van Straten, P. den Heijer, M. Bentala, V.V. van Ommen, J. Kluin, P.R. Stella, J.G. Maessen, F.W. Prinzen
Journal: Circulation (2011)
TCT-14 Invasive Versus Medical Management in Patients With Chronic Kidney Disease and Non–ST-Elevation Myocardial Infarction
Authors: Ankur Kalra, Monil Majmundar, Gabriel Ibarra, Ashish Kumar, Rajkumar Doshi, Palak Shah, Roxana Mehran, Grant Reed, Rishi Puri, Samir Kapadia, Sripal Bangalore
Journal: Journal of the American College of Cardiology (2021)
Inborn errors of TLR3- or MDA5-dependent type I IFN immunity in children with enterovirus rhombencephalitis
Authors: Jie Chen, Huie Jing, Andrea Martin-Nalda, Paul Bastard, Jacques G. Rivière, Zhiyong Liu, Roger Colobran, Danyel Lee, Wesley Tung, Jeremy Manry, Mary Hasek, Soraya Boucherit, Lazaro Lorenzo, Flore Rozenberg, Mélodie Aubart, Laurent Abel, Helen C. Su, Pere Soler Palacin, Jean-Laurent Casanova, Shen-Ying Zhang
Journal: The Journal of Experimental Medicine (2021)

Enterovirus (EV) infection rarely results in life-threatening infection of the central nervous system. We report two unrelated children with EV30 and EV71 rhombencephalitis. One patient carries compound heterozygous TLR3 variants (loss-of-function F322fs2* and hypomorphic D280N), and the other is homozygous for an IFIH1 variant (loss-of-function c.1641+1G&amp;gt;C). Their fibroblasts respond poorly to extracellular (TLR3) or intracellular (MDA5) poly(I:C) stimulation. The baseline (TLR3) and EV-responsive (MDA5) levels of IFN-β in the patients’ fibroblasts are low. EV growth is enhanced at early and late time points of infection in TLR3- and MDA5-deficient fibroblasts, respectively. Treatment with exogenous IFN-α2b before infection renders both cell lines resistant to EV30 and EV71, whereas post-infection treatment with IFN-α2b rescues viral susceptibility fully only in MDA5-deficient fibroblasts. Finally, the poly(I:C) and viral phenotypes of fibroblasts are rescued by the expression of WT TLR3 or MDA5. Human TLR3 and MDA5 are critical for cell-intrinsic immunity to EV, via the control of baseline and virus-induced type I IFN production, respectively.
TCT-338 Distance to Nearest Cardiac Catheterization Laboratory Is Associated With Reduced Ventricular Fibrillation Mortality Rate in the US
Authors: Gustavo Porto, Behnood Bikdeli, Ankur Kalra, Debabrata Mukherjee, Partha Sardar, Saurav Chatterjee
Journal: Journal of the American College of Cardiology (2021)
Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia
Authors: Shailaja Hegde, Anjelika Gasilina, Mark Wunderlich, Yuan Lin, Marcel Buchholzer, Oliver H. F. Krumbach, Mohammad Akbarzadeh, Mohammad Reza Ahmadian, William Seibel, Yi Zheng, John P. Perentesis, Benjamin E. Mizukawa, Lisa Privette Vinnedge, José A. Cancelas, Nicolas N. Nassar
Journal: Leukemia (2021)

Abstract Aberrant RHO guanine nucleotide exchange factor (RhoGEF) activation is chief mechanism driving abnormal activation of their GTPase targets in transformation and tumorigenesis. Consequently, a small-molecule inhibitor of RhoGEF can make an anti-cancer drug. We used cellular, mouse, and humanized models of RAC-dependent BCR-ABL1-driven and Ph-like acute lymphoblastic leukemia to identify VAV3, a tyrosine phosphorylation–dependent RacGEF, as the target of the small molecule IODVA1. We show that through binding to VAV3, IODVA1 inhibits RAC activation and signaling and increases pro-apoptotic activity in BCR-ABL1-transformed cells. Consistent with this mechanism of action, cellular and animal models of BCR-ABL1-induced leukemia in Vav3 -null background do not respond to IODVA1. By durably decreasing in vivo RAC signaling, IODVA1 eradicates leukemic propagating activity of TKI-resistant BCR-ABL1(T315I) B-ALL cells after treatment withdrawal. Importantly, IODVA1 suppresses the leukemic burden in the treatment refractory pediatric Ph + and TKI-resistant Ph + B-ALL patient-derived xenograft models better than standard-of-care dasatinib or ponatinib and provides a more durable response after treatment withdrawal. Pediatric leukemia samples with diverse genetic lesions show high sensitivity to IODVA1 ex vivo and this sensitivity is VAV3 dependent. IODVA1 thus spearheads a novel class of drugs that inhibits a RacGEF and holds promise as an anti-tumor therapy.
Nuclear TIGAR mediates an epigenetic and metabolic autoregulatory loop via NRF2 in cancer therapeutic resistance
Authors: Hong Wang, Qianqian Wang, Guodi Cai, Zhijian Duan, Zoann Nugent, Jie Huang, Jianwei Zheng, Alexander D. Borowsky, Jian Jian Li, Peiqing Liu, Hsing-Jien Kung, Leigh Murphy, Hong-Wu Chen, Junjian Wang
Journal: Acta Pharmaceutica Sinica B (2021)

Metabolic and epigenetic reprogramming play important roles in cancer therapeutic resistance. However, their interplays are poorly understood. We report here that elevated TIGAR (TP53-induced glycolysis and apoptosis regulator), an antioxidant and glucose metabolic regulator and a target of oncogenic histone methyltransferase NSD2 (nuclear receptor binding SET domain protein 2), is mainly localized in the nucleus of therapeutic resistant tumor cells where it stimulates NSD2 expression and elevates global H3K36me2 mark. Mechanistically, TIGAR directly interacts with the antioxidant master regulator NRF2 and facilitates chromatin recruitment of NRF2, H3K4me3 methylase MLL1 and elongating Pol-II to stimulate the expression of both new (NSD2) and established (NQO1/2, PRDX1 and GSTM4) targets of NRF2, independent of its enzymatic activity. Nuclear TIGAR confers cancer cell resistance to chemotherapy and hormonal therapy in vitro and in tumors through effective maintenance of redox homeostasis. In addition, nuclear accumulation of TIGAR is positively associated with NSD2 expression in clinical tumors and strongly correlated with poor survival. These findings define a nuclear TIGAR-mediated epigenetic autoregulatory loop in redox rebalance for tumor therapeutic resistance.
Guselkumab-Associated Severe AKI from Collapsing Glomerulopathy
Authors: Varun Madireddy, Deepa A. Malieckal, Boonyanuth N. Maturostrakul, Philip S. Yune, Vanesa Bijol, Hitesh H. Shah
Journal: Journal of the American Society of Nephrology (2021)

Madireddy, Varun; Malieckal, Deepa A.; Maturostrakul, Boonyanuth N.; Yune, Philip S.; Bijol, Vanesa; Shah, Hitesh H. Author Information
White adipocyte-targeted dual gene silencing of FABP4/5 for anti-obesity, anti-inflammation and reversal of insulin resistance: Efficacy and comparison of administration routes
Authors: Jee Young Chung, Juhyeong Hong, Hyung-Jin Kim, Yoonsung Song, Seok-Beom Yong, Jieun Lee, Yong-Hee Kim
Journal: Biomaterials (2021)
TCT-434 Sex Differences in Ischemic or Bleeding Outcomes of Percutaneous Coronary Intervention With Drug-Eluting Stents by Using Short Versus Standard Duration of Dual-Antiplatelet Therapy
Authors: Sumit Sohal, Umair Khan, Krishna Prasad Kurpad, Akhilesh Thakur, Karan Wats, Annabelle Volgman
Journal: Journal of the American College of Cardiology (2021)
Humoral and cellular immune responses to recombinant herpes zoster vaccine in patients with chronic lymphocytic leukemia and monoclonal B cell lymphocytosis
Authors: Eli Muchtar, Amber B. Koehler, Michael J. Johnson, Kari G. Rabe, Wei Ding, Timothy G. Call, Jose F. Leis, Saad S. Kenderian, Suzanne R. Hayman, Yucai Wang, Paul J. Hampel, Matthew A. Holets, Heather C. Darby, Susan L. Slager, Neil E. Kay, Congrong Miao, Jennifer Canniff, Jennifer A. Whitaker, Myron J. Levin, D. Scott Schmid, Richard B. Kennedy, Adriana Weinberg, Sameer A. Parikh
Journal: American Journal of Hematology (2021)

Abstract Monoclonal B‐cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL) are clonal B‐cell disorders associated with an increased risk of infections and impaired vaccination responses. We investigated the immunogenicity of recombinant zoster vaccine (RZV) in these patients. Individuals with MBL/untreated CLL and Bruton tyrosine kinase inhibitor (BTKi)‐treated CLL patients were given two doses of RZV separated by 2 months. Responses assessed at 3 and 12 months from the first dose of RZV by an anti‐glycoprotein E ELISA antibody assay and by dual‐color Interferon‐γ and Interleukin‐2FLUOROSPOT assays were compared to historic controls matched by age and sex. About 62 patients (37 MBL/untreated CLL and 25 BTKi‐treated CLL) were enrolled with a median age of 68 years at vaccination. An antibody response at 3 months was seen in 45% of participants, which was significantly lower compared to historic controls (63%, p = .03). The antibody response did not significantly differ between MBL/untreated CLL and BTKi‐treated CLL (51% vs. 36%, respectively, p = .23). The CD4+ T‐cell response to vaccination was significantly lower in study participants compared to controls (54% vs. 96%, p &lt; .001), mainly due to lower responses among BTKi‐treated patients compared to untreated MBL/CLL (32% vs. 73%, p = .008). Overall, only 29% of participants achieved combined antibody and cellular responses to RZV. Among participants with response assessment at 12 months ( n = 47), 24% had antibody titers below the response threshold. Hypogammaglobulinemia and BTKi therapy were associated with reduced T‐cell responses in a univariate analysis. Strategies to improve vaccine response to RZV among MBL/CLL patients are needed.
TCT-252 Temporal Trends in Patient Outcomes and Resource Utilization in a Large US Population After TAVR
Authors: Michael Fatuyi, Leanne Pereira, Awfa Zain Elabidin, Vahid Namdarizandi, Oluwafunmilayo Fatuyi, Rukayat Otulana, Vivek Sharma, Asimul Ansari, Kamal Shemisa, Puvi Seshiah
Journal: Journal of the American College of Cardiology (2021)
TCT-39 Bleeding and Ischemic Outcomes With Ticagrelor Monotherapy According to Body Mass Index: TWILIGHT-BMI Analysis
Authors: Carlo Andrea Pivato, Davide Cao, Vijay Kunadian, Samantha Sartori, Zhongjie Zhang, George Dangas, Dominick Angiolillo, Carlo Briguori, David Cohen, C. Michael Gibson, David Moliterno, Samin Sharma, Javier Escaned, Stuart Pocock, Roxana Mehran
Journal: Journal of the American College of Cardiology (2021)
The Tale of Two Collapsing Glomerulopathies Associated with COVID-19 in Stamford Hospital
Authors: Mariana A. Chang, Revekka Babayev
Journal: Journal of the American Society of Nephrology (2021)

Journal of the American Society of Nephrology 32(10S):p 776, October 2021. | DOI: 10.1681/ASN.20213210S1776a
TCT-40 Medication Use and 3-Year Mortality After Transcatheter Aortic Valve Replacement (TAVR): Findings From Real-World Claims Data
Authors: Robert Cubeddu, Shannon Murphy, Craig Asher, Santiago Garcia, Juan Granada, Brian Lindman, Creighton Don, Eduardo Perez, Joao Cavalcante, Megan Coylewright, Rebecca Hahn, Omar Khalique, Philippe Genereux, Pradeep Yadav, Vinod Thourani, Martin Leon
Journal: Journal of the American College of Cardiology (2021)
TCT-291 Clinical and Echocardiographic Outcomes of Transcatheter Mitral Valve Repair in Atrial Functional Mitral Regurgitation
Authors: Tomás Benito-González, Fernando Carrasco, Rodrigo Estévez Loureiro, Isaac Pascual, Dabit Arzamendi, Carmen Garrote, Luis Nombela-Franco, Manuel Pan, Ana Serrador, Xavier Freixa, Leire Andraka, Ignacio Cruz-Gonzalez, Jose Ramon Lopez-Minguez, Jose L. Diez-Gil, Cristóbal A. Urbano Carrillo, Dario Sanmiguel, Juan Sanchis Fores, Valeriano Ruiz Quevedo, Eduardo Molina Navarro, Victor Becerra-Muñoz, Pablo Avanzas, Chi Hion Li, Pilar Jimenez-Quevedo, Dolores Mesa Rubio, Ignacio Amat-Santos, Ander Regueiro, Ramiro Trillo Nouche, Juan Alonso Brailes, Felipe Fernandez-Vazquez
Journal: Journal of the American College of Cardiology (2021)
Transfer factor of the lung for carbon monoxide: what is the significance of an abnormal result?
Authors: Mike Hughes
Journal: European Respiratory Journal (2021)

In respiratory publications, there is a distinction between articles focusing on pathogenesis, which is linked to diagnosis, and those dealing with function, which is important for treatment. In the COVID-19 pandemic, an understanding of viral structure and replication underpinned the development of vaccines; on the other hand, the monitoring of pulmonary function was essential for deciding oxygen requirements and the need for ventilatory assistance. The study published in this issue of the European Respiratory Journal by Miller and Cooper [1] deals with pulmonary function testing, and with one test in particular, one of the most important, namely the carbon monoxide transfer factor ( T LCO). The authors address an apparently simple problem: how to grade an abnormal T LCO in terms of severity, with its implications for survival. An abnormal T LCO value is predictive of survival <https://bit.ly/2RmgCXF>