tbuckley/cabot-search huggingface dataset:
Editorial Board
Authors: Donald Leung, Stanley Szefler, Colo Associate, Cezmi Akdis, Davos Switzerland, Andrea Apter, Pedro Philadelphia, Chicago Avila, Bruce Bochner, Joshua Boyce, David Broide, La Jolla, Robert Calif, Madison Bush, Fred Finkelman, Dennis Ledford, David Peden, Marc Rothenberg, Cincinnati Ohio, William Shearer, Scott Sicherer, New York, Donata Vercelli, Ariz Statistics Editor, Vernon Chinchilli
Journal: Journal of Allergy and Clinical Immunology (2009)
Lectures on Diseases of Women and Children
Authors: C. H. F. Routh
Journal: BMJ (1862)

CONSEQUENCES OF ENDOMETRITIS.GENTLEMEN,-In my last lecture I spoke of endo- metritis.To-day I pass on to the consequences of this disease upon the generative organs themselves; for time would not allow me to refer to those which affect more generally the system.I shall allude especially to the following-i.Mucous Polypi; ii.Dysmenorrhoea; iii.Occlusion of the Internal and External Os; iv.Physometra and Hydrometra; v. Displacements of the Uterus-Retroversion and Anteversion; vi.Hypertrophy of the Cervix; and VII.Sterility.I. Mucous POLYPI.You will remember that,
Abstract 140: Utilization of Mechanical CPR Is Highly Variable Within the National EMS Information System Dataset
Authors: David G Buckler, Nabil Abdulhay, Konstantinos Totolos, Benjamin Abella
Journal: Circulation (2018)

Background: Randomized controlled trials have demonstrated neither survival benefit nor harm from use of mechanical CPR (mCPR). Retrospective analyses have shown an association between mCPR and worse survival outcomes, even when controlling for differences in patient mix and arrest duration. Nonetheless, studies have suggested mCPR use increased from 2013 to 2016. Objective: We sought to quantify the proportion of out-of-hospital cardiac arrest (OHCA) cases in the US with utilization of mCPR and use in conjunction with other procedures. Methods: Using Emergency Medical Services (EMS) call data from the National EMS Information System (NEMSIS) Dataset, we identified non-traumatic OHCA with EMS resuscitation. Procedure codes were classified as “Mechanical CPR”, “Advanced Airway”, “IO”, “IV”, “Defibrillation”, “Other” and “No Procedures”. The NEMSIS Dataset includes US Census Region, Division, and urbanicity for each call. Results: In 2016, there were 29,919,652 EMS activations reported, 151,333 met inclusion criteria and 138,555 included procedure codes. Of the OHCA cohort, the mean age was 63±20 yrs, 39% were female, 86% occurred prior to EMS arrival, 62% occurred in a home/residence, 18% in public, and 14% in healthcare facilities. mCPR was used in 10% of all cases. Reported regional utilization varied from 4.8% in the Northeast to 14.9% in the South (p&lt;0.001). mCPR did not vary significantly based on urbanicity (range: 10.4% to 11.4%, p=0.34). In multiple logistic regression controlling for age, gender, location of arrest, race and ethnicity, and region, mCPR utilization was more likely if an advanced airway was placed (OR: 1.74, CI: 1.58-1.91), and less likely if an IV or IO was placed (IV: OR 0.75, CI 0.71 - 0.79; IO: OR 0.37, CI 0.28 - 0.48). 4,928 cases contained information on survival to admission. Of these, overall survival to admission was 27%, with no significant difference between mCPR and no mCPR groups. Survival to discharge data was available for 2,476 subjects (1.8% of OHCA cohort). Survival to discharge was higher among the non-mCPR group (13.8% vs. 10.3%, p = 0.011). Conclusion: In NEMSIS, reported mCPR utilization is highly variable across the US. The overall proportion of cases receiving mCPR is lower than previous registry-based studies.
Exercise and Blood Donation
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Arterial Embolectomy
Authors: A. M. McMaster
Journal: BMJ (1939)

VENEREAL DISEASE PROBLEM IN MALAYA MECALSUHNAL 441 of Singapore gaol, and the ratio of positives, Chinese to Indians, was 29 to 18. Applying this to the rate for Indians of 10 per cent., the rate for Chinese would be 16.6 per cent.The social conditions of Chinese also favour a higher prevalence of syphilis and gonorrhoea.As to the Malays, there is little evidence at present of widespread venereal disease among them.The fact that their conditions of life are such as to favour a lower prevalence than in the case of Indians or Chinese lends support to this view.Further investigation is, however, required.Conclusions Examination of conditions at present in the F.M.S. shows:1. (a) That social conditions in the population vary from race to race; that these conditions are such in relation to Chinese, Indians, and Malays as to favour, in varying degrees, the prevalence of venereal disease; and that disease probably exists in decreasing amounts among them in that order.(b) That the Medical Department's report of a fall in incidence in venereal diseases in the F.M.S is not necessarily true if based on the evidence in the Annual Reports of the Medical Department, F.M.S.2. That the incidence of syphilis among Indian male labourers is in the region of 10 per cent.3. That enough evidence is available to warrant a survey of the whole question and the closest investigation of it with a view to the control of venereal disease.I have to thank Dr. H. M.
Tracheostomy
Authors: H. M. Dukes
Journal: Thorax (1970)

In this paper a comparison has been made between excision-type window tracheostomies and classical Björk flap and modified flap tracheostomies, based upon a review of all tracheostomies performed at Harare Hospital, Salisbury, over a 20-month period, together with bronchoscopic follow-up whenever possible. The modified flap type of tracheostomy is constructed by means of a broad-based flap dividing two tracheal rings and having rounded corners. It produces a good stoma through which tube changing can be performed with ease and safety. Any form of permanent defect in the trachea left by merely extubating a tracheostomy will almost always produce a narrowing at the level of the stoma, which is probably most severe if a flap-type of stoma has been made. Routine replacement of a modified flap will nearly always avoid this. A serious stricture was produced in three (3%) patients in the series. In two, this was at the level of the tube tip in patients who had been on prolonged artificial ventilation; one required resection. These strictures are probably due to movement of the tube tip during ventilator therapy, and it is suggested that some method of coupling the ventilator to the tube might be devised to avoid this.
Abstract 171: Developing an ECPR Program for Out of Hospital Cardiac Arrest
Authors: Meshe Chonde, Jeremiah Escajeda, Jonathan Elmer, Arthur Boujoukos, Penny L Sappington, Frank X Guyette, Anson J Smith, Mark Schmidhofer, Clifton Callaway, Christopher M Sciortino, Robert L Kormos
Journal: Circulation (2018)

Introduction: Extracorporeal cardiopulmonary resuscitation (ECPR) has emerged as a novel treatment for cardiac arrest that is refractory to conventional cardiopulmonary resuscitation (CPR). As part of a quality improvement initiative we sought to develop a program at our institution. Hypothesis: ECPR is a feasible and effective alternative means of resuscitation for patients in refractory cardiac arrest. Methods: We developed a multidisciplinary ECPR team consisting of staff from Emergency Medical Services (EMS), Emergency Department, Cardiology, Cardiac Surgery and Critical Care Medicine. Patients with an out of hospital cardiac arrest (OHCA) refractory to medical treatment were identified by EMS and brought to our institution if they met our program selection criteria. The patient was cannulated in the Emergency Department or Catheterization Laboratory, then underwent coronary angiogram with intervention if applicable and was transferred to cardiothoracic intensive care unit (ICU) for further care. Results: From October 1 st 2015 to March 31 st 2018, a total of 1165 out of hospital cardiac arrests occurred, of which five met criteria for our study. Median age was 47 [IQR 32-53] and four were men. Most common arrest rhythm was VF (80%), one patient had ST elevation on EKG. Time from arrest to initiation of ECMO was 63 [IQR 59-69] min with 5 [IQR 3-6] defibrillations and 6 [IQR 6-7] doses of epinephrine administered. Four patients were successfully cannulated (80%). Cannulation time was 21 [IQR 16-33] min, with one patient achieving ROSC during cannulation. All patients underwent angiography, with two patients receiving coronary intervention (40%). ECMO duration was 48 [IQR 38-68] hours and length of stay was 2 [IQR 2-8] days. All patients had an initial Pittsburgh Cardiac Arrest Category of 4. Two patients (40%) survived to hospital discharge with good neurologic function. Conclusions: ECPR is a potentially life-saving alternative treatment to conventional CPR that is feasible in our patient population.
MATERNAL AND PEDIATRIC CARE OF SERVICEMEN'S DEPENDENTS
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Arrhythmias in Female Patients: Incidence, Presentation and Management
Authors: Emily P. Zeitler, Jeanne E. Poole, Christine M. Albert, Sana M. Al-Khatib, Fatima Ali-Ahmed, Ulrika Birgersdotter-Green, Yong-Mei Cha, Mina K. Chung, Anne B. Curtis, Jodie L. Hurwitz, Rachel Lampert, Roopinder K. Sandhu, Fatima Shaik, Erin Sullivan, Kamala P. Tamirisa, Annabelle Santos Volgman, Jennifer M. Wright, Andrea M. Russo
Journal: Circulation Research (2022)

There is a growing appreciation for differences in epidemiology, treatment, and outcomes of cardiovascular conditions by sex. Historically, cardiovascular clinical trials have under-represented females, but findings have nonetheless been applied to clinical care in a sex-agnostic manner. Thus, much of the collective knowledge about sex-specific cardiovascular outcomes result from post hoc and secondary analyses. In some cases, these investigations have revealed important sex-based differences with implications for optimizing care for female patients with arrhythmias. This review explores the available evidence related to cardiac arrhythmia care among females, with emphasis on areas in which important sex differences are known or suggested. Considerations related to improving female enrollment in clinical trials as a way to establish more robust clinical evidence for the treatment of females are discussed. Areas of remaining evidence gaps are provided, and recommendations for areas of future research and specific action items are suggested. The overarching goal is to improve appreciation for sex-based differences in cardiac arrhythmia care as 1 component of a comprehensive plan to optimize arrhythmia care for all patients.
ASTHMA IN CHILDREN
Authors: R. H. Simpson, K. Stone
Journal: BMJ (1929)

RADIOGRAPHIC FTNDINXTS IN PAINFUL SHOULDERS.IM THESRs 291 was sen:t only for a radiographic examination of the teeeth, sinuses, --etc.Frequently the radiograTih -o-f the painfdl joint shtowed no bone or joilnt change,, but definite apica ¶ abscesses or evidence of sinus ifiiection were detected.2Th,~Royal St -Chad's~Pensions ' Queen's C Hosp itae.Uosnpitals.d -IlopiaL Hosits.HoIa.-Hsitl.cTotal ... ...
Familial Hyperparathyroidism
Authors: P. Marsden, J. Anderson, D. Doyle, B. A. Morris, D. A. Burns
Journal: BMJ (1971)

Twenty-eight members of a family over three generations were studied; six of them had hyperparathyroidism. Four of the six were siblings and one of these had suffered from recurrent hyperparathyroidism. No member of the family showed any other significant endocrine disturbance or active peptic ulceration. Attention is drawn to the prominent lack of symptoms despite dangerous levels of hypercalcaemia and advanced disease with the consequent need for estimation of serum calcium levels in all close relatives. Multiple gland involvement is common in familial hyperparathyroidism and is often coupled with a tendency to recurrence, necessitating long-term follow-up. Histological appearances vary considerably, and the risk of recurrence is not limited to cases showing primary chief cell hyperplasia, with the implication that resection of three parathyroid glands and part of the remaining gland may be the treatment of choice in all cases of familial hyperparathyroidism when multiple gland involvement is found.
Defining innate immune training potential as a predictor of Bacillus Calmette-Guérin immunotherapy response in nonmuscle-invasive bladder cancer.
Authors: Song Jiang, Gil Redelman-Sidi, Eugene J. Pietzak, Bernard H. Bochner, Michael S Glickman
Journal: Journal of Clinical Oncology (2022)

522 Background: Intravesical instillation of the live attenuated mycobacterium Bacillus Calmette-Guerin (BCG) remains the most effective therapy for the treatment of non-muscle invasive bladder cancer. The precise mechanism of BCG is thought to involve phagocytosis, induction of inflammation, activation of the innate immune apparatus, and an effective cell-mediated T cell response. An increasing body of evidence suggests that the innate immune system has characteristics that involve a heterologous memory of past insults through a process thought to involve epigenetic reprogramming, termed trained immunity. We seek to investigate the potential for innate immune training as a predictor of the anti-tumor effects of BCG. Methods: A prospective biospecimen collection was performed on venous blood from non-muscle invasive bladder cancer patients prior to receiving intravesical BCG therapy. To investigate the role of trained immunity in primary monocytes, cells were isolated from peripheral blood mononuclear cells (PBMC) by plate adhesion. 2-5 x 10 5 cells/well were assayed in 96-well format, cultured in RPMI 1640 supplemented with 10% Fetal Bovine Serum and 2mM L-glutamine and stimulated with 10:1 MOI BCG for 24 hours. Cells were then washed in media and allowed to rest 6 days. Media was changed on day 3 of rest. Subsequently, cells were stimulated with 25 ng/ml lipopolysaccharide (a TLR4 agonist) for 24 hours. Cell free supernatant was measured for TNF-alpha production by enzyme-linked immunosorbent assay. Results: In vitro training of primary monocytes induced an increase in proinflammatory cytokine production upon re-stimulation. This phenotype was dose dependent on stimulation with LPS, however, the relative change between trained and untrained cells was diminished at higher concentrations of agonist. In our in vitro training experiments, there was demonstrable interpatient variability seen pre-BCG exposure in a cohort of NMIBC patients. These results will be correlated with future long term BCG response in this prospective cohort. Conclusions: We present data on a trained innate immune phenotype on primary monocytes collected from patient samples. These data serve as proof of principle for the ability to induce a trained phenotype in vitro. These findings will be correlated with prospective clinical data on BCG responsiveness and recurrence free survival to allow us to garner further insight into the role of trained immunity in BCG immunotherapy. Such insight will have potential clinical impact on the development of biomarkers and clinical assays that could predict immune responsiveness to BCG a priori, as well as identify possible immunological adjuvants that could enhance the effect of intravesical BCG.
Reassurance
Authors: A. B. Carter
Journal: BMJ (1955)

ConclusionDiphtheria is a rare disease at the moment, but positive laboratory reports are still common.Treatment depends primarily on the signs and symptoms, and no laboratory report should create a clinical emergency.The fever hospital clinician or the medical officer of health should be consulted when swabs are reported positive.Patients should not be rushed into hospital because something has grown in a laboratory.
NECROLOGY.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Purpura on the Rocks—With a Twist
Authors: Robert R. Siroty
Journal: JAMA (1976)

THE ENTITY of quinine-induced purpura is well recognized and has been described many times. On several occasions, its relation to the ingestion of cocktails mixed with quinine water—so-called cocktail purpura or gin-and-tonic purpura—has been reported.<sup>1,2</sup>We recently encountered a well-disguised case with potentially serious consequences. <h3>Report of a Case</h3> A 27-year-old woman was admitted to Dover General Hospital in January 1973 with chills and the rapid development of purpura, including buccal mucous membrane hemorrhages. Platelet count was 1,000/cu mm; other laboratory data were normal. The patient had had a recent episode of acute gastroenteritis but was otherwise well. She denied taking any drugs except a mixture of chlorpheniramine maleate, aspirin, and caffeine (Coricidin) and aspirin and denied drinking quinine-containing cocktails. Bone-marrow examination revealed abundant numbers of normal-appearing megakaryocytes and normal myeloid and erythroid elements. The patient was treated with prednisone (40 mg/day) and had a rapid and sustained rise
THE PERSONNEL OF STATE MEDICAL EXAMINING BOARDS.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Liver injury.
Authors: H Bharucha, L R Marwah, J G Paul
Journal: BMJ (1972)

A + 0 + B Mothers 22680 21218 1-07 Mothers Different 9108 8391 1 09 and BabiesThe Same 14537 13609 1-07 ence which is reciprocal to it-that is, by a lower sex ratio for non-B babies of B mothers and non-O babies of 0 mothers than for non-A babies of A mothers.That is to say, the 1924-72 aggregate presents a clear-cut difference in sex ratio between the babies of two contrasted types of mother- namely, mothers whose babies are of the same ABO blood group as themselves, and those whose babies are of another group from themselves-the difference being significant for B mothers (P<005), 0 mothers (P<005), and A mothers (P<O0OOO5).A difference parallel to the one observed in A mothers is seen in AB mothers-it is evident in the Table , and is present even in Hirszfeld and Zborowski's series-but here the difference is not significant (P> 0-10), whatever may eventuate when the aggregate is added to.A detailed account and discussion are being prepared in which the idea will be considered that the phenomena are the result of unknown effects of steroid hormones.
Trichobezoar
Authors: F. M. Parsons
Journal: BMJ (1947)

stained fluid.Two tablets were returned whole.There was no haematemesis.His colour became waxy, but had improved before admission to hospital the same day at 2.5 p.m.He was very thirsty.A stool passed later in the day was dark and gave the guaiac reaction for blood.On admission he was rather flushed, listless, and drowsy, his pulse was regular and of good volume.There was neither tenderness nor abnormal resistance over his abdomen.Treat- ment consisted of mist.magnesium hydroxide and bismuth, along with glucose and saline, later changed to milk and subsequently to milk diet.By March 6 the vomiting had ceased, and on the 9th the stool was 'normal, with no blood.On the 13th the child was 'very well, but the stool 'was 'dark and the guaiac test positive.He had had no meat since admission.On the 16th the stool was again dark, and on the 1Sth he was well and there was no melaena.