Metabolically Healthy Obesity and Development of Chronic Kidney Disease
Authors: Dustin J. Little, Wondaye T. Deressa, Maura A. Watson, Christina M. Yuan
Journal: Annals of Internal Medicine (2016)

Letters15 November 2016Metabolically Healthy Obesity and Development of Chronic Kidney DiseaseDustin J. Little, MD, Wondaye T. Deressa, NP, Maura A. Watson, MD, and Christina M. Yuan, MDDustin J. Little, MDFrom Walter Reed National Military Medical Center, Bethesda, Maryland.Search for more papers by this author, Wondaye T. Deressa, NPFrom Walter Reed National Military Medical Center, Bethesda, Maryland.Search for more papers by this author, Maura A. Watson, MDFrom Walter Reed National Military Medical Center, Bethesda, Maryland.Search for more papers by this author, and Christina M. Yuan, MDFrom Walter Reed National Military Medical Center, Bethesda, Maryland.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L16-0406 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Chang and colleagues (1) investigated rates of CKD in metabolically healthy obese persons compared with those in normal-weight Korean adults. Metabolically healthy obese participants were significantly more likely to develop an estimated GFR calculated by the 4-variable MDRD (Modification of Diet in Renal Disease) study equation of less than 60 mL/min/1.73 m2, but substantial methodological limitations call into question the authors' conclusions that metabolically healthy obesity is associated with CKD and adversely affects renal function.The absence of data on albuminuria is a major weakness of this analysis and precludes a basic assessment of the participants' CKD ...References1. Chang Y, Ryu S, Choi Y, Zhang Y, Cho J, Kwon MJ, et al. Metabolically healthy obesity and development of chronic kidney disease: a cohort study. Ann Intern Med. 2016;164:305-12. [PMID: 26857595]. doi:10.7326/M15-1323 LinkGoogle Scholar2. Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl. 2013;3:1-150. Google Scholar3. Baxmann AC, Ahmed MS, Marques NC, Menon VB, Pereira AB, Kirsztajn GM, et al. Influence of muscle mass and physical activity on serum and urinary creatinine and serum cystatin C. Clin J Am Soc Nephrol. 2008;3:348-54. [PMID: 18235143] doi:10.2215/CJN.02870707 CrossrefMedlineGoogle Scholar4. Inker LA, Schmid CH, Tighiouart H, Eckfeldt JH, Feldman HI, Greene T, et al; CKD-EPI Investigators. Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med. 2012;367:20-9. [PMID: 22762315] doi:10.1056/NEJMoa1114248 CrossrefMedlineGoogle Scholar5. Little DJ, Mascio HM, Altenburg RJ, Moon DS, Deressa WT, Wong S, et al. Implementing GFR estimation guidelines using cystatin C: a quality improvement project [Letter]. Am J Kidney Dis. 2016;67:711-2. [PMID: 26616337] doi:10.1053/j.ajkd.2015.10.014 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Walter Reed National Military Medical Center, Bethesda, Maryland.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L16-0406. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMetabolically Healthy Obesity and Development of Chronic Kidney Disease Yoosoo Chang , Seungho Ryu , Yuni Choi , Yiyi Zhang , Juhee Cho , Min-Jung Kwon , Young Youl Hyun , Kyu-Beck Lee , Hyang Kim , Hyun-Suk Jung , Kyung Eun Yun , Jiin Ahn , Sanjay Rampal , Di Zhao , Byung-Seong Suh , Eun Cheol Chung , Hocheol Shin , Roberto Pastor-Barriuso , and Eliseo Guallar Metabolically Healthy Obesity and Development of Chronic Kidney Disease Fatima Cody Stanford and W. Scott Butsch Metabolically Healthy Obesity and Development of Chronic Kidney Disease Henry S. Kahn and Meda E. Pavkov Metabolically Healthy Obesity and Development of Chronic Kidney Disease Yoosoo Chang , Seungho Ryu , Juhee Cho , Roberto Pastor-Barriuso , and Eliseo Guallar Metrics 15 November 2016Volume 165, Issue 10Page: 743-744KeywordsBody weightCreatinineDisclosureKidneysMortalityObesityOverweightRenal analysisRenal diseasesRenal failure ePublished: 15 November 2016 Issue Published: 15 November 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...