tbuckley/cabot-search huggingface dataset:
Abstract 17412: Current Experience and Limitations of Extracorporeal Cardiopulmonary Resuscitation for Cardiac Arrest: A Single-Center Retrospective Study
Authors: Aditi Singhvi, Nirav Patel, Jason A Gluck
Journal: Circulation (2018)

Introduction: Extracorporeal cardiopulmonary resuscitation (ECPR) may be considered for select cardiac arrest patients for whom the suspected etiology of the arrest is potentially reversible. In adults, the survival to discharge with ECPR is reportedly 22% to 33%, with better outcomes for in-hospital arrests. Outcomes with ECPR depend on multiple factors including, location of arrest, etiology, duration and quality of CPR, time to initiation of ECMO, and post-arrest management. There is no consensus regarding patient selection or management of these patients. We report our preliminary experiences with ECPR for refractory cardiac arrest. Methods: Patients who underwent ECPR between January 2013 and May 2018 were identified. The characteristics of the arrest, CPR duration, cannulation procedure, post-arrest management, complications, survival and neurologic outcomes were retrospectively reviewed. Results: A total of 24 ECPR events were identified. The median age was 60 years. The median CPR duration and time from collapse to initiation of ECMO were 35 (IQR 25.5-68) and 68 (IQR 45.5-144.5) min, respectively. Peripheral and central access sites were employed in 19 and 5 cases, respectively. Return of spontaneous circulation was achieved in 21 patients (87.5%). PCI was performed on 4 and pulmonary embolectomy on 3 patients. Median duration of ECMO support was 84 (IQR 24-168) hours. Major complications occurred in 17 patients (70.8%). Nine patients (37.5%) were successfully weaned from ECMO and 7 (29.2%) survived to hospital discharge. All of the survivors had a favorable neurologic outcome. Conclusions: ECPR as part of a comprehensive multi-faceted approach for select patients with refractory cardiac arrest may improve outcomes. We noted an improvement in outcomes over time. This could be attributed to improved selection criteria as well as clinical management. The development of selection criteria may help identify patients most likely to benefit from the use of ECPR. This would have significant resource implications for hospitals with ECMO programs.
NOTES ON SMALL-POX
Authors: W. M. Wanklyn
Journal: BMJ (1922)

tM yw?A I 1xi8r 4. Without expressing an opinion in regard to the therapeutic value of the sernm in the treatment of pneumonia, the test by titrage in the mouse, when controlled by a standard serum, affords a basis for the international standardization of the serum.Thera- peutic serum mav be titrated in mice either by injecting intra- peritoneally a fixed quantity (0.2 c.cm.) of serum mixed with a
Transsexualism observed.
Authors: H R Rollin
Journal: BMJ (1982)

Transsexualism observed "Vive la difference" might well be the mating call of the lusty, masculine male, a male, that is, who is not only biologically masculine but whose gender identity is the same.A very few biological males exist, however, whose gender identity is decidedly feminine and who regard "la difference" as an abomination.They see themselves unequivocally as women, a belief which reaches near-delusional proportions-and one which may be reinforced by narrowing the gap between fantasy and reality by the surgical removal of the offending male sexual organs and the substitution of simulated female ones.Such grossly aberrant men are true transsexuals (the condition occurs less often in women) and are to be differen- tiated from transvestites, who obtain a degree of sexual excitement from cross-dressing, or homosexuals, who know themselves to be men but obtain sexual gratification mainly or exclusively from other men.The three conditions can, however, overlap to some extent.With modern hormonal procedures coupled with advances in the technique of plastic surgery the operation demanded by male transsexuals is now available-sex reassignment surgery.From time to time the names of alleged successes hit the head- lines as, for example, those of Christine Jorgensen, Roberta Cowell, Jan Morris, and, a relatively recent addition to the list, that of the six-feet-tall top model Tula.Of particular importance is the case of April Ashley, n'e George Jamieson, not so much because George Jamieson was transformed into what Judge Ormrod had occasion subse- quently to term "a convincing feminine pastiche" but because of the autobiographical account1 of her case just published.Marred as it is by a good deal of literary candyfloss and unnecessary revelations of the goings on among the somewhat rancid social creme de la creme with whom she mixed, the book is, nevertheless, an excellent account of male trans- sexualism and one which should commend itself to anyone interested in this intriguing but sad human condition.April Ashley fulfils almost all the criteria needed to establish a diagnosis of the syndrome.The environmental setting was right.She despised her father, who was a cook in the Royal Navy and not often at home and whom she describes in no uncertain terms as a scoundrel and a boozer.She was, therefore, driven into a dependence on and preference for her mother.Her psychosexual development was right; at the age of 15 she said of herself: "I was taunted for being like a girl and, yes, I wanted to be one."This preoccupation with her gender identity grew: "I was convinced a monstrous mistake had been made and only my being a woman would correct it."After one of several suicide attempts she was admitted to a mental hospital, where heroic attempts were made to alter her determination.She was subjected to ether and thiopentone abreactions and to electric convulsion therapy and given male hormones.It all ended in dismal failure.She told her doctor, "No matter what you do you'll never be able to change my mind."
International Cooperative Group for Bone Marrow Transplantation
Journal: JNCI Journal of the National Cancer Institute (1974)

International Cooperative Group for Bone Marrow Transplantation Get access JNCI: Journal of the National Cancer Institute, Volume 52, Issue 1, January 1974, Page 309, https://doi.org/10.1093/jnci/52.1.309-a Published: 01 January 1974
St. George's Hospital
Authors: T. Jones
Journal: BMJ (1863)

a musician, was suffering from severe tic in the light cheek, and had the muscles of this side of the face d1rawn and contracted to a considerable degree.With tew intervals, he had suffered from the pain for three and a half years.The face became contracted on the painful side two years ago.Before the pain began, he had been treated for three months with iodide of potas- sium for constitutional syphilis.He smoked exces- sivelv, anid allowed that he had for inany years been -very intemperate in sexual matters.His dinner con- sisted chiefly of a beef-steak and a pint of stout, taken at a chop-house.He drank tea in large quantity, taking it -cold with his tobacco.He never drank any spirits.He had had nearly all his teeth drawn, in the hope that the pain in the cheek might be referred to the irritation from some diseased tooth.He was recommended to smoke less, and to try a mild tobacco when he did smoke; to take coffee in place of tea; to eat oily and fatty matters, and less lean meat; and to talke three drachms of cod-liver oil and ten grains of lhypophosphite of soda three times a day.Mlarch '':3rd.For the last three days he had been almost altogether free from pain; and last night he slept for several hours continuously (he had been re- commended to take a glass of stout shortly before goingr to bed).This-i.e., sleeping satisfactorily-for several years bad been unknown to him.MIarch 10th.Hie had had no pain whatever since last visit, and considered himself quite well.May 19th.Except an occasional pang, for which he said there lhad been generally good reason, the tic might be said to be altogether at an end.He had lost alto- gether the anxious nervous look wvhich he had when I first saw hiim; and the contracted facial muscles had almost altogether recovered their natural condition.CASE V. M. W., aged 28, a lady's maid, suffered from almost constant nervous headaches.She had never been ,quite free from these pains for two years, but lately they hiad beeni much worse-so much worse, that she was now compelled to leave a good situation.A great moral shock, arising from the discovery of a fellow-servant dead by her side on waking in the morning, was referred to as the cause of the pain.She had ha(d a great deal of medicine; but did not k-now what kinld of medicines were given, except that they were generally intended to act on the bowels, and to promote menstruation, which was always very scanty and painful, and wlich was once, six or seven years aao, often accompanied with a great deal of hysterical agita- tion.She was ordered to take cod-liver oil and hypoplhosphite of soda, with middle diet and porter.April 4th.Tlhe oil made her sick.She was ordered to take the hypophosphite by itself.April Gth.Slhe slept much better, and wolke this morning without lheadache-a thing she had not done for two years.She was ordered to resume the oil.April 8th.She was evidently gaining ground.She had a bad headaclle now, brought on, it appears, by a violent altercation with anotber patient in the same ward.The medicine was continued.April 15th.She had been improving progressively
Scintigraphy of the Skull and Facial Bones
Authors: Dov Front, Ruth Hardoff, Galina Yoselevski, Eliezer Robinson
Journal: JAMA (1978)

THE VALUE of scintigraphy of the cranial and facial bones has received little attention in the literature in comparison with the many articles published about scintigraphy of the axial skeleton. The normal anatomy of the skull in scintigraphy was described by Jones and Patton<sup>1</sup>and Bergstedt.<sup>2</sup>Gates and Goris<sup>3</sup>described scintigraphic findings in maxillofacial abnormalities. Coleman et al<sup>4</sup>stated that "routine skull images in addition to axial skeletal images are of limited value." We report here our experience in a group of patients in whom scintigraphy of the cranial and facial bones was most helpful in management. <h3>Patients and Methods</h3> Twenty-one patients were examined because of signs of a mass in the soft tissues of the head, swelling of the face, or exophthalmos. Skull scintigraphy was performed three hours after the intravenous injection of 15 mCi of technetium Tc 99m diphosphonate. Multiple views were taken with a
Experience with Renal Biopsy in Children: Preliminary Report
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute Meningitis
Authors: J. H. Paterson
Journal: BMJ (1956)

Few medical conditions demand more urgent treat- ment than acute meningitis, yet its early diagnosis is often difficult, particularly in young children and infants, in whom the classical features by which it is recognized are often inconspicuous or absent.Yet early diagnosis is vital, for in general the mortality figures are in direct proportion to the duration of the delay in diagnosis and the institution of treatment.Acute meningitis can be considered under two main headings, acute pyogenic meningitis and acute lymphocytic meningitis (Table I), according to the nature of the meningeal reaction and the corresponding cellular changes in the cerebrospinal fluid.A detailed consideration of the lymphocytic meningitides is beyond the scope of this article, though some of its causes are noted below.TABLE I.-Cornmoner Formiis of Acute Meninzgitis Acute pyogenic mZenin7gitis:
A Court of Decency for Physicians
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Near miss cot deaths and home monitoring
Authors: Ian Mccoll
Journal: BMJ (1983)

like to see this prejudiced by rigid policy decisions.In the last 20 years 1315 operations have been carried out safely and satisfactorily on children under the age of 15, many on a day admission basis.These have included appendicectomy, circumcision, herniotomy, and orchidopexy.
New knees for old.
Journal: BMJ (1972)

New Knees for OldOperations to treat the arthritic knee may be divided into three groups: on soft tissues, on bones, and the arthroplasties.The only soft-tissue operation is synovectomy.It can benefit a chronically swollen, painful rheumatoid knee that has not responded to thorough medical treatment.Two operations on bones commonly performed are the high tibial osteotomy popularized by M. Coventry' and A. Ben- jamin's double osteotomy,2 wherein both the lower end of the femur and upper end of the tibia are cut.These opera- tions are of greatest benefit in the treatment of an osteo- arthritic knee accompanied by valgus or varus deformities.Also within this group comes arthrodesis, applicable to both rheumatoid and osteoarthritic knees.It is the only operation which, if successful, gives complete relief of pain, but since the result is total loss of function of the knee joint its applications are limited.In an arthroplasty of any joint the aim is to relieve symp- toms and maintain or restore function to the joint.The first attempt at an arthroplasty was performed by J. B. Murphy in America in 1913 using fat and fascia as a lining for the joint.3In 1940 W. C. Campbell4 reported on the use of vitallium plates as a covering for the femoral condyles.Two cases were operated on; both failed.William N.Jones, of the Massachusetts General Hospital, revived the possibility of covering the femoral condyles with a vitallium cap and in 1971 reported good or very good results in 50% of rheumatoid knees.5 D. L. MacKintosh6 and D. C. McKeever both concentrated on replacing one or both tibial plateaux with implants, initially of plastic but subsequently of chrome-cobalt alloy.These operations were used in the treatment of both rheumatoid and osteoarthritic knees, and MacKintosh in 1971 reported 69% success rate with his prosthesis.T. A. Potter, M. S. Weinfeld, and W. H. Thomas,7 using the McKeever prosthesis, obtained good or excellent results in 56% of rheumatoid knees and in nearly 85% of osteo- arthritic knees.Such excellent results are not always reported, and L. G. P. Shiers,8 9 reviewing the world literature on knee arthroplasty in 1960, found a success rate of 42.7% in a total of 831 cases.In the nast 15 years attempts have been made to produce an entirely artificial knee joint.Interest in it has revived owing to the dramatic results of total hip replacement.
Racial, ethnic, and geographical differences in testicular cancer mortality trends in the United States.
Authors: Anushka Ghosh, Saveli Goldberg, Fumiko Chino, Jason A. Efstathiou, Sophia C. Kamran
Journal: Journal of Clinical Oncology (2022)

409 Background: Incidence rates of Testicular cancer (TC) have been slowly increasing in the United States in recent decades. Prior research has identified racial disparities in mortality; however, these trends have not been extensively evaluated. Given that TC has a diverse presentation, this study was undertaken to establish racial, ethnic, geographical differences in longitudinal mortality trends. Methods: Age-adjusted cancer mortality rates for TC were obtained for men in the United States from the CDC Wide-ranging Online Data for Epidemiologic Research database. Testicular cancer-specific mortality (TCSM) rates from 1999-2019 were calculated using linear regression. Trends in mortality by race (White versus Black), ethnicity (Hispanic versus non-Hispanic), urbanization, and census region were analyzed using SAS 9.4. TCSM rates were compared by F-test. A two-sided hypothesis test was performed for p-values, where values &lt; 0.05 were considered statistically significant. Results: From 1999-2019, overall age-adjusted TCSM has been slowly, but not significantly, increasing per year (Table). There was worsening TCSM rates for Hispanics (+)0.0019 per 100,000 compared to non-Hispanics (-)0.003; p=0.010. Black men had slightly improved TCSM rates/year (-0.0007) compared to white men (+0.0006); p=0.049. Significant geographical differences in mortality rates were observed, with a decreasing TCSM rate of (-)0.00092 the Northeast and an increasing rate of (+)0.00086 in the West (p = 0.032 for difference between slopes). Among urbanization categories, TCSM rates in Large Central Metros regions (central counties in metro areas with population &gt; 1 million) and Small Metro regions (counties with population 50,000-249,999) were significantly different [(-)0.0004 and (+)0.0022 respectively; p =0.048]. All other comparisons were not significant. Conclusions: Using comprehensive, contemporary data on TCSM over 2 decades, we found significant differences in TCSM rates. Mortality rates from TC have been increasing, particularly among Hispanics. Understanding racial, ethnic, and geographical trends in TCSM rates is important in treating men with the disease and, ultimately, reducing deaths caused by TC.[Table: see text]
Measuring Clinical, Biological, and Behavioral Variables to Elucidate Trajectories of Patient-Reported Outcomes: The PROFILES Registry
Authors: Lonneke V van de Poll-Franse, Nicole Horevoorts, Dounya Schoormans, Sandra Beijer, Nicole P M Ezendam, Olga Husson, Simone Oerlemans, Sanne B Schagen, Geja J Hageman, Katrijn Van Deun, Corina van den Hurk, Mies van Eenbergen, Floortje Mols, Belle de Rooij, Natasja Raijmakers, Carla Vlooswijk, Cynthia Bonhof, Afke Ekels, Meeke Hoedjes, S J M van Cappellen – van Maldegem, Laurien Ham, Danielle van de Graaf, Janneke van Roij
Journal: JNCI Journal of the National Cancer Institute (2022)

Abstract To take cancer survivorship research to the next level, it’s important to gain insight in trajectories of changing patient-reported outcomes and impaired recovery after cancer. This is needed as the number of survivors is increasing and a large proportion is confronted with changing health after treatment. Mechanistic research can facilitate the development of personalized risk-stratified follow-up care and tailored interventions to promote healthy cancer survivorship. We describe how these trajectories can be studied by taking the recently extended Dutch population-based Patient Reported Outcomes Following Initial treatment and Long term Evaluation of Survivorship (PROFILES) registry as an example. PROFILES combines longitudinal assessment of patient-reported outcomes with novel, ambulatory and objective measures (eg, activity trackers, blood draws, hair samples, online food diaries, online cognitive tests, weighing scales, online symptoms assessment), and cancer registry and pharmacy databases. Furthermore, we discuss methods to optimize the use of a multidomain data collection–like return of individual results to participants, which may improve not only patient empowerment but also long-term cohort retention. Also, advanced statistical methods are needed to handle high-dimensional longitudinal data (with missing values) and provide insight into trajectories of changing patient-reported outcomes after cancer. Our coded data can be used by academic researchers around the world. Registries like PROFILES, which go beyond boundaries of disciplines and institutions, will contribute to better predictions of who will experience changes and why. This is needed to prevent and mitigate long-term and late effects of cancer treatment and to identify new interventions to promote health.