tbuckley/cabot-search huggingface dataset:
Medications in Single-Dose Vials and Implications of Discarded Injectable Drugs
Authors: Edward H. Shortliffe, Gary H. Lyman, Francis K. Amankwah
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Siglec-6 is a target for chimeric antigen receptor T-cell treatment of chronic lymphocytic leukemia
Authors: Damian Kovalovsky, Jeong Heon Yoon, Matthew G. Cyr, Samantha Simon, Elisaveta Voynova, Christoph Rader, Adrian Wiestner, Julie Alejo, Stefania Pittaluga, Ronald E. Gress
Journal: Leukemia (2021)
Endoscopic retrograde appendicitis therapy: new approach in the treatment of stump appendicitis
Authors: Felix Haller, Christoph Gasche
Journal: Endoscopy (2021)

A 34-year-old woman presented at a primary care hospital with recurrent abdominal pain. Abdominal ultrasonography revealed a thickened terminal ileum with mesenteric wrapping and enlarged lymph nodes suggestive of Crohn's disease. A month earlier the patient had had appendicitis with subsequent laparoscopic appendectomy. On suspicion of Crohn's disease, the patient was started on budesonide 9 mg once daily. As there was no clinical improvement after 3 weeks she was referred to our institution.
Announcing the Lancet Commission on Vaccine Refusal, Acceptance, and Demand in the USA
Authors: Peter J. Hotez, Rebecca E. Cooney, Regina M. Benjamin, Noel T. Brewer, Alison M. Buttenheim, Timothy Callaghan, Arthur Caplan, Richard M. Carpiano, Chelsea Clinton, Renee DiResta, Jad A. Elharake, Lisa C. Flowers, Alison P. Galvani, Rekha Lakshmanan, Yvonne A. Maldonado, SarahAnn M. McFadden, Michelle M. Mello, Douglas J. Opel, Dorit R. Reiss, Daniel A. Salmon, Jason L. Schwartz, Joshua M. Sharfstein, Saad B. Omer
Journal: The Lancet (2021)
Paying the Right Amount to Challenge Trial Participants – We Need to Use Behavioral Science Insights to Sell What’s Right
Authors: Peter A Ubel, J.S. Blumenthal-Barby
Journal: The American Journal of Bioethics (2021)

"Paying the Right Amount to Challenge Trial Participants – We Need to Use Behavioral Science Insights to Sell What’s Right." The American Journal of Bioethics, 21(3), pp. 38–39
Promoting reproducibility with Code Ocean
Authors: Barbara Cheifet
Journal: Genome biology (2021)

Genome Biology has built a reputation in the community for our strong data deposition policies [1].We require our published methods and software to have their source code deposited on a public software repository, such as Github, and in a DOI-assigning repository, such as zenodo.The source code must also be released under an open source license compliant with OSI, and this must be clearly stated on the repository and in the manuscript.Not only is it essential to have code available for reproducing results, but it enables other researchers to build on the work or find potential pitfalls of a method.As editors, we assume that our reviewers are looking at source code to some extent; however, it is difficult to determine how thoroughly a code has been analyzed.We recognize that reviewing code can be cumbersome, as authors must first make sure that code is accessible for reviewers to check, and reviewers must then be able to download the code and data and make sure that they have the correct dependencies installed to be able to confirm the reproducibility of the results.In addition, a reviewer's identity could be revealed unintentionally if downloading a software from a page controlled by the author(s).Recently, several Nature journals, including Nature Methods, Nature Biotechnology, and Nature Machine Intelligence completed a trial with Code Ocean, a cloud-based reproducibility platform that aims to help reviewers and authors facilitate peer review of source code [2,3].This trial has since been made permanent and expanded to other journals at Springer Nature, including BMC Bioinformatics and Scientific Data.Genome Biology is excited to announce that at the end of 2020, we also have partnered with Code Ocean, with the aim of making the peer review of source code easier for both reviewers and authors.Code Ocean is based on Docker and serves as a platform for the deposition of all code and data necessary for reproducing analysis in the cloud.The platform integrates the source code, metadata, and dependencies into one "capsule" within a single, userfriendly web interface.By doing so, it ensures that all data required for re-analysis is available and that reviewers have easy access to it from any set-up or personal computer.It also provides a check that the code supplied compiles and runs.Users and reviewers also have the ability to upload their own data for testing or to experiment themselves with parameter options.
His Bundle Pacing with Recruitment of Right Bundle Branch after Orthotopic Heart Transplant
Authors: Kristin Ellison
Journal: Clinical Cardiology and Cardiovascular Interventions (2021)

The incidence of permanent pacemaker implant after orthotopic heart transplant is between 2-24%. We present a 63-year-old male with ischemic cardiomyopathy who underwent orthotopic heart transplant. His post-operative course was complicated by recurrent asystole from sinus bradycardia and complete heart block. He had baseline right bundle branch block and right ventricular dysfunction. The decision was made to proceed with His-bundle pacing to provide physiologic cardiac activation, and provide anatomical benefit for subsequent endomyocardial biopsy. He did well after receiving a His bundle pacemaker with recruitment of his right bundle branch.
Association between medical resources and the proportion of oldest-old in the Chinese population
Authors: Chao Tan, Cai-Zhi Tang, Xing-Shu Chen, Yong-Jun Luo
Journal: Military Medical Research (2021)

The potential association between medical resources and the proportion of oldest-old (90 years of age and above) in the Chinese population was examined, and we found that the higher proportion of oldest-old was associated with the higher number of beds in hospitals and health centers.
Impact of in-season injury on quality of life and sleep duration in female youth volleyball athletes: a prospective study of 2073 players
Authors: Andrew Watson, Kevin Biese, Stephanie A Kliethermes, Eric Post, M Alison Brooks, Pamela J Lang, David R Bell, Kristin Haraldsdottir, Timothy McGuine
Journal: British Journal of Sports Medicine (2021)

Objectives The psychological impacts of injuries in youth athletes remain poorly defined. The purpose of this study was to evaluate the influence of injury on quality of life (QOL) and sleep in female high school volleyball athletes. Methods 2073 female high school volleyball players (15.6±1.1 years) completed the Pediatric Quality of Life survey (total QOL, physical, social, school, emotional and psychosocial function) and reported average sleep duration at the start and end of the season. Injury data were collected by school athletic trainers. Mixed effects linear regression models were used to compare changes in QOL and sleep duration during the season between (1) injured and uninjured athletes and (2) injured athletes who did or did not suffer a season-ending injury. Results Time-loss injuries were reported in 187 athletes with complete preseason and postseason data. During the season, injured athletes demonstrated a greater decrease in total QOL (β=−1.3±0.5, p=0.012), as well as physical function (β=−1.6±0.6, p=0.012), school function (β=−2.0±0.76, p=0.01) and psychosocial function domains (β=−1.2±0.6, p=0.039) compared with uninjured athletes. Athletes who sustained a season-ending injury had a significantly greater decrease in total QOL (β=−6.8±2.0, p=0.006) and physical function (β=-17±2.9, p&lt;0.001) compared with injured athletes who were able to return to play during the season. Conclusion In-season injuries are associated with significant decreases in total QOL as well as physical and psychosocial function. Healthcare providers should consider the impacts of injuries on QOL and sleep in youth athletes in order to optimise management and improve overall health.
18F-FDG PET/CT Detection of a Popliteal Mycotic Aneurysm Complicating Staphylococcus aureus Bacteremia
Authors: Yacine El Yaagoubi, Caroline Prunier-Aesch, Alain Chetanneau, Laurent Philippe, François Bleuet, Eric Menard, Gérard Doll
Journal: Clinical Nuclear Medicine (2021)

A 75-year-old man presented with Staphylococcus aureus bacteremia, fever, and right posterior knee pain. Venous Doppler ultrasound of the lower extremity showed an isolated right calf muscle vein thrombosis, without any sign of deep vein thrombosis. 18F-FDG PET/CT revealed an intense focal uptake on the right popliteal artery, suggesting a mycotic aneurysm (MA). Lower limb CT angiography confirmed an MA of the right popliteal artery. The patient underwent surgical procedure with excision of the MA, whose cultures grew methicillin-sensitive S. aureus. Our case highlights the importance of including lower limbs in 18F-FDG PET/CT acquisition in case of suspicion of septic emboli.
Abstract SS2-03: Patterns of medical behavior in the management of breast cancer during COVID-19. Mexican Experienc
Authors: Ricardo Villalobos Valencia, Samuel Rivera Rivera
Journal: Cancer Research (2021)

Abstract Objective. This survey was conducted with medical oncologists treating breast cancer and explores how the COVID-19 pandemic has impacted their approach to managing breast cancer.Method. A questionnaire of ten questions was sent electronically to 123 medical oncologists throughout the Mexican Republic from June 25 to 29, 2020, a critical moment in our patient with the highest reports of new cases of patients with COVID-19.Results. Of the respondents, 47.1% work in a public and private hospital, 21.9% and 30.0% exclusively in the public and private respectively. Modification of treatment schemes due to the pandemic is reported in 42.5% (51) and 34.1% (41) occasionally. The dose modification has occurred mainly in the palliative context 71.3%. The modification of intravenous to oral chemotherapy was confirmed in 78.2% of the respondents, but this was in less than 30% of the patients. Only 27.1% of doctors have prolonged their chemotherapy schedules. To the question of postponing visits in patients under surveillance or in adjuvant with endocrine therapy, 80% of the doctors answered confirmatory. Private online consultation has been implemented in 57.8% of doctors. When asked to have patients with breast cancer and a positive test for COVID-19, 37% (43 doctors) confirmed having had patients. Delays in diagnostic protocols for breast cancer were reported in 74.5% (85). Finally 37.7% reported that less than 25% of their patients did not attend their scheduled appointment and 32.4% of the doctors reported that between 25% to 50% of their patients postponed the medical visit. (See images of results).Conclusion. In Mexico, like many countries, the treatment and follow-up of patients with breast cancer has been affected by the pandemic, a factor that impacts the results is that in our country we have a shortage of oncological drugs for more than a year, including sometimes cyclophosphamide, anthracyclines and taxanes that are essential for this disease. Management and diagnosis protocols have been delayed since medical care has been prioritized for patients with COVID-19. Unfortunately, there is no national registry of cancer patients, much less the association of cancer with COVID-19. The study, however, reflects similarity of results with other countries in medical behavior. Citation Format: Ricardo Villalobos Valencia, Samuel Rivera Rivera. Patterns of medical behavior in the management of breast cancer during COVID-19. Mexican Experienc [abstract]. In: Proceedings of the 2020 San Antonio Breast Cancer Virtual Symposium; 2020 Dec 8-11; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2021;81(4 Suppl):Abstract nr SS2-03.
Hyperphosphatemia in chronic kidney disease exacerbates atherosclerosis via a mannosidases-mediated complex-type conversion of SCAP N-glycans
Authors: Chao Zhou, Quan He, Hua Gan, Tingting Zeng, Qiao Liu, John F. Moorhead, Zac Varghese, Nan Ouyang, Xiong Z. Ruan
Journal: Kidney International (2021)
Therapeutic Targeting of DGKA-Mediated Macropinocytosis Leads to Phospholipid Reprogramming in Tuberous Sclerosis Complex
Authors: Andrii Kovalenko, Andres Sanin, Kosmas Kosmas, Long Zhang, Ji Wang, Elie W. Akl, Krinio Giannikou, Clemens K. Probst, Thomas R. Hougard, Ryan W. Rue, Vera P. Krymskaya, John M. Asara, Hilaire C. Lam, David J. Kwiatkowski, Elizabeth P. Henske, Harilaos Filippakis
Journal: Cancer Research (2021)

Abstract Lymphangioleiomyomatosis is a rare destructive lung disease affecting primarily women and is the primary lung manifestation of tuberous sclerosis complex (TSC). In lymphangioleiomyomatosis, biallelic loss of TSC1/2 leads to hyperactivation of mTORC1 and inhibition of autophagy. To determine how the metabolic vulnerabilities of TSC2-deficient cells can be targeted, we performed a high-throughput screen utilizing the “Repurposing” library at the Broad Institute of MIT and Harvard (Cambridge, MA), with or without the autophagy inhibitor chloroquine. Ritanserin, an inhibitor of diacylglycerol kinase alpha (DGKA), was identified as a selective inhibitor of proliferation of Tsc2−/− mouse embryonic fibroblasts (MEF), with no impact on Tsc2+/+ MEFs. DGKA is a lipid kinase that metabolizes diacylglycerol to phosphatidic acid, a key component of plasma membranes. Phosphatidic acid levels were increased 5-fold in Tsc2−/− MEFs compared with Tsc2+/+ MEFs, and treatment of Tsc2−/− MEFs with ritanserin led to depletion of phosphatidic acid as well as rewiring of phospholipid metabolism. Macropinocytosis is known to be upregulated in TSC2-deficient cells. Ritanserin decreased macropinocytic uptake of albumin, limited the number of lysosomes, and reduced lysosomal activity in Tsc2−/− MEFs. In a mouse model of TSC, ritanserin treatment decreased cyst frequency and volume, and in a mouse model of lymphangioleiomyomatosis, genetic downregulation of DGKA prevented alveolar destruction and airspace enlargement. Collectively, these data indicate that DGKA supports macropinocytosis in TSC2-deficient cells to maintain phospholipid homeostasis and promote proliferation. Targeting macropinocytosis with ritanserin may represent a novel therapeutic approach for the treatment of TSC and lymphangioleiomyomatosis. Significance: This study identifies macropinocytosis and phospholipid metabolism as novel mechanisms of metabolic homeostasis in mTORC1-hyperactive cells and suggest ritanserin as a novel therapeutic strategy for use in mTORC1-hyperactive tumors, including pancreatic cancer.
Nanoparticles that do not compete with endogenous ligands – Molecular characterization in vitro, acute safety in canine, and interspecies pharmacokinetics modeling to humans
Authors: Dianxiong Zou, Meenakshi Arora, Raghu Ganugula, Mokshada Kumar, Erin M. Scott, Dhaval Shah, M.N.V. Ravi Kumar
Journal: Journal of Controlled Release (2021)
Bronchiectasis severity correlates with outcome in patients with primary antibody deficiency
Authors: Jimstan Periselneris, Silke Schelenz, Michael Loebinger, Patricia Macedo, Zoe Adhya, Darius Armstrong-James, W Peter Kelleher
Journal: Thorax (2021)

Bronchiectasis is a well-recognised complication of primary antibody deficiency (PAD) syndromes. Previous data suggest that mortality in common variable immune deficiency (CVID) is not associated with isolated bronchiectasis. A retrospective analysis of patients with CVID and specific antibody deficiency in two tertiary referral centres with lung disease was conducted. Severity of bronchiectasis at presentation was associated with mortality. Lower FEV1, colonisation with Pseudomonas aeruginosa and a diagnosis of COPD were also associated with mortality. Bronchiectasis is an important driver of mortality in patients with PAD syndromes.
The actin-regulatory protein Hem-1 is essential for alveolar macrophage development
Authors: Nutthakarn Suwankitwat, Stephen Libby, H. Denny Liggitt, Alan Avalos, Alanna Ruddell, Jason W. Rosch, Heon Park, Brian M. Iritani
Journal: The Journal of Experimental Medicine (2021)

Hematopoietic protein-1 (Hem-1) is a hematopoietic cell–specific actin-regulatory protein. Loss-of-function (LOF) variants in the NCKAP1L gene encoding Hem-1 have recently been found to result in primary immunodeficiency disease (PID) in humans, characterized by recurring respiratory infections, asthma, and high mortality. However, the mechanisms of how Hem-1 variants result in PID are not known. In this study, we generated constitutive and myeloid cell–specific Nckap1l-KO mice to dissect the importance of Hem-1 in lung immunity. We found that Hem-1–deficient mice accumulated excessive surfactant and cell debris in airways (pulmonary alveolar proteinosis) due to impaired development of alveolar macrophages (AMs) and reduced expression of the AM differentiation factor Pparg. Residual Hem-1–deficient AMs shifted to a proinflammatory phenotype, and Hem-1–deficient neutrophils and monocytes failed to migrate normally. Myeloid cell–specific Hem-1–deficient mice exhibited increased morbidity following influenza A virus or Streptococcus pneumoniae challenge. These results provide potential mechanisms for how LOF variants in Hem-1 result in recurring respiratory diseases.
Abstract 15833: Tea Domain Family Member 1 (TEAD1) Regulates IGF1 and mTOR Pathway in the Heart
Authors: Rajaganapathi Jagannathan, Jeongkyung Lee, Ruya Liu, Ping Yang, Feng Li, Vinny Negi, Vijay Yechoor, Mousumi Moulik
Journal: Circulation (2019)

Introduction: We previously demonstrated that TEAD1, the transcriptional effector of the Hippo pathway, plays a critical non-redundant role in neonatal and adult heart and its loss-of-function (LOF...
Coronary microcirculation damage in anthracycline cardiotoxicity
Authors: Carlos Galán-Arriola, Jean Paul Vílchez-Tschischke, Manuel Lobo, Gonzalo J López, Antonio de Molina-Iracheta, Claudia Pérez-Martínez, Rocio Villena-Gutiérrez, Álvaro Macías, Iván A Díaz-Rengifo, Eduardo Oliver, Valentin Fuster, Javier Sánchez-González, Borja Ibanez
Journal: Cardiovascular Research (2021)

Abstract Aims The aim of this study was to study changes in coronary microcirculation status during and after several cycles of anthracycline treatment. Methods and results Large-white male pigs (n=40) were included in different experimental protocols (ExPr.) according to anthracycline cumulative exposure [0.45 mg/kg intracoronary (IC) doxorubicin per injection] and follow-up: control (no doxorubicin); single injection and sacrifice either at 48 h (ExPr. 1) or 2 weeks (ExPr. 2); 3 injections 2 weeks apart (low cumulative dose) and sacrifice either 2 weeks (ExPr. 3) or 12 weeks (ExPr. 4) after third injection; five injections 2 weeks apart (high cumulative dose) and sacrifice 8 weeks after fifth injection (ExPr. 5). All groups were assessed by serial cardiac magnetic resonance (CMR) to quantify perfusion and invasive measurement of coronary flow reserve (CFR). At the end of each protocol, animals were sacrificed for ex vivo analyses. Vascular function was further evaluated by myography in explanted coronary arteries of pigs undergoing ExPr. 3 and controls. A single doxorubicin injection had no impact on microcirculation status, excluding a direct chemical toxicity. A series of five fortnightly doxorubicin injections (high cumulative dose) triggered a progressive decline in microcirculation status, evidenced by reduced CMR-based myocardial perfusion and CFR-measured impaired functional microcirculation. In the high cumulative dose regime (ExPr. 5), microcirculation changes appeared long before any contractile defect became apparent. Low cumulative doxorubicin dose (three bi-weekly injections) was not associated with any contractile defect across long-term follow-up, but provoked persistent microcirculation damage, evident soon after third dose injection. Histological and myograph evaluations confirmed structural damage to arteries of all calibres even in animals undergoing low cumulative dose regimes. Conversely, arteriole damage and capillary bed alteration occurred only after high cumulative dose regime. Conclusion Serial in vivo evaluations of microcirculation status using state-of-the-art CMR and invasive CFR show that anthracyclines treatment is associated with progressive and irreversible damage to the microcirculation. This long-persisting damage is present even in low cumulative dose regimes, which are not associated with cardiac contractile deficits. Microcirculation damage might explain some of the increased incidence of cardiovascular events in cancer survivors who received anthracyclines without showing cardiac contractile defects.
Methodologic Concerns With Concluding a Link Between Epidural and Autism Spectrum Disorder
Authors: Adina R. Kern-Goldberger, Heather H. Burris, Lisa D. Levine
Journal: JAMA Pediatrics (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Post-error recruitment of frontal sensory cortical projections promotes attention in mice
Authors: Kevin J. Norman, Justin S. Riceberg, Hiroyuki Koike, Julia Bateh, Sarah E. McCraney, Keaven Caro, Daisuke Kato, Ana Liang, Kazuhiko Yamamuro, Meghan E. Flanigan, Korey Kam, Elisa N. Falk, Daniel M. Brady, Christina Cho, Masato Sadahiro, Kohei Yoshitake, Priscilla Maccario, Michael P. Demars, Leah Waltrip, Andrew W. Varga, Scott J. Russo, Mark G. Baxter, Matthew L. Shapiro, Peter H. Rudebeck, Hirofumi Morishita
Journal: Neuron (2021)