Treating Type 2 Autoimmune Pancreatitis With Colchicine: A Case Series
Authors: Filippo Chiabrando, Marco Lanzillotta, Diego Palumbo, Federica Pedica, Martina Caruso, Gabriele Capurso, Emanuel Della-Torre
Journal: Annals of Internal Medicine (2021)

LettersDecember 2021Treating Type 2 Autoimmune Pancreatitis With Colchicine: A Case SeriesFilippo Chiabrando, MD, Marco Lanzillotta, MD, Diego Palumbo, MD, Federica Pedica, MD, PhD, Martina Caruso, MD, Gabriele Capurso, MD and Emanuel Della-Torre, MD, PhDFilippo Chiabrando, MDUniversità Vita-Salute San Raffaele, San Raffaele Scientific Institute, Milan, Italy, Marco Lanzillotta, MDUniversità Vita-Salute San Raffaele, San Raffaele Scientific Institute, Milan, Italy, Diego Palumbo, MDUniversità Vita-Salute San Raffaele, San Raffaele Scientific Institute, Milan, Italy, Federica Pedica, MD, PhDUniversità Vita-Salute San Raffaele, San Raffaele Scientific Institute, Milan, Italy, Martina Caruso, MDUniversity of Naples Federico II, Naples, Italy, Gabriele Capurso, MDUniversità Vita-Salute San Raffaele, San Raffaele Scientific Institute, Milan, Italy and Emanuel Della-Torre, MD, PhDUniversità Vita-Salute San Raffaele, San Raffaele Scientific Institute, Milan, ItalyAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L21-0281 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Type 2 autoimmune pancreatitis (AIP) is characterized histologically by a neutrophilic infiltrate organized in granulocytic epithelial lesions (GELs) (1). Corticosteroids are used to induce remission, and azathioprine is commonly used as maintenance therapy (2).Objective: To report successful treatment of type 2 AIP with colchicine.Case Report: Patient 1 was a 19-year-old man with no history of alcohol or recreational drug misuse who presented to the emergency department in late November 2017 with abdominal pain, a serum amylase level of 3.01 µkat/L (normal, 0.47 to 1.67 µkat/L), and a lipase level of 1.97 µkat/L (normal, 0 to 1.00 µkat/L). ...References1. Shimosegawa T, Chari ST, Frulloni L, et al; International Association of Pancreatology. International consensus diagnostic criteria for autoimmune pancreatitis: guidelines of the International Association of Pancreatology. Pancreas. 2011;40:352-8. [PMID: 21412117] doi:10.1097/MPA.0b013e3182142fd2 CrossrefMedlineGoogle Scholar2. Okazaki K, Chari ST, Frulloni L, et al. International consensus for the treatment of autoimmune pancreatitis. Pancreatology. 2017;17:1-6. [PMID: 28027896] doi:10.1016/j.pan.2016.12.003 CrossrefMedlineGoogle Scholar3. Mancuso G, Boffini N, Dagna L, et al. Colchicine as a new therapeutic option for antithyroid arthritis syndrome [Letter]. Rheumatology (Oxford). 2020;59:1452-1453. [PMID: 31697376] doi:10.1093/rheumatology/kez547 CrossrefMedlineGoogle Scholar4. Ku Y, Hong SM, Fujikura K, et al. IL-8 expression in granulocytic epithelial lesions of idiopathic duct-centric pancreatitis (type 2 autoimmune pancreatitis). Am J Surg Pathol. 2017;41:1129-1138. [PMID: 28614208] doi:10.1097/PAS.0000000000000891 CrossrefMedlineGoogle Scholar5. Ter Haar N, Lachmann H, Özen S, et al; Paediatric Rheumatology International Trials Organisation (PRINTO) and the Eurofever/Eurotraps Projects. Treatment of autoinflammatory diseases: results from the Eurofever Registry and a literature review. Ann Rheum Dis. 2013;72:678-85. [PMID: 22753383] doi:10.1136/annrheumdis-2011-201268 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Università Vita-Salute San Raffaele, San Raffaele Scientific Institute, Milan, ItalyUniversity of Naples Federico II, Naples, ItalyUniversità Vita-Salute San Raffaele, San Raffaele Scientific Institute, Milan, Italy* Drs. Chiabrando and Della-Torre are equally contributing first authors.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L21-0281.Corresponding Author: Emanuel Della-Torre, MD, PhD, Università Vita-Salute San Raffaele, IRCCS San Raffaele Scientific Institute, via Olgettina 60, Milan, 20132 Italy; e-mail, dellatorre.[email protected]it.This article was published at Annals.org on 12 October 2021. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics December 2021Volume 174, Issue 12Page: 1775-1776KeywordsCOVID-19CellsColchicineComputed axial tomographyEmergency departmentMethotrexateMutationNeutrophilsPancreatitisUltrasound imaging ePublished: 12 October 2021 Issue Published: December 2021 Copyright & PermissionsCopyright © 2021 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...