tbuckley/cabot-search huggingface dataset:
High levels of chromosomal aberrations negatively associate with benefit to checkpoint inhibition in NSCLC
Authors: Joan Frigola, Caterina Carbonell, Patricia Iranzo, Nuria Pardo, Ana Callejo, Susana Cedres, Alex Martinez-Marti, Alejandro Navarro, Mireia Soleda, Jose Jimenez, Javier Hernandez-Losa, Ana Vivancos, Enriqueta Felip, Ramon Amat
Journal: Journal for ImmunoTherapy of Cancer (2022)

Background Immune checkpoint inhibitors (ICIs) targeting the programmed cell death 1/programmed death-ligand 1 axis have transformed the management of advanced non-small cell lung cancer (NSCLC). However, many patients do not benefit from this type of treatment, and thus several molecular biomarkers of benefit have been explored. The value of somatic copy number alterations (SCNAs) burden remains elusive. Patients and methods We assembled a cohort of 109 patients with NSCLC treated with ICIs and available tumor samples. We performed shallow whole-genome sequencing on 89 patients to determine genome-wide SCNAs and targeted gene expression analysis on 63 patients to study immune infiltration. We analyzed SCNAs burden in different ways (ie, the fraction of the genome altered or number of events) and studied their association with ICIs benefit based on survival analysis. We correlated SCNAs burden and immune infiltration on 35 patients of our cohort and on patients with lung adenocarcinoma from The Cancer Genome Atlas (TCGA). Results High SCNAs burden, computed in diverse ways, is negatively associated with ICIs progression-free survival (PFS), with the fraction of the genome altered (FGA) by arm and chromosome events showing the strongest association with PFS (p=0.002) (n=77). Nevertheless, we found differences in SCNAs across some clinicopathological features (sample site origin). A multivariate analysis adjusted for relevant characteristics showed that the FGA of arm and chromosome alterations was strongly associated with PFS (HR=2.21, p=3.3 x 10 −5 ). Finally, we confirmed that SCNAs burden negatively correlates with tumor immune infiltration (n=35), although this correlation was not found for the males studied. Similar results were observed in the TCGA cohort. Conclusions SCNAs burden is a potential biomarker of benefit to ICIs in patients with NSCLC, although there appear to be some nuances worth consideration. Further studies will be needed to establish its role as a biomarker of benefit to ICIs.
Bacterial Toxin‐Triggered Release of Antibiotics from Capsosomes Protects a Fly Model from Lethal Methicillin‐Resistant <i>Staphylococcus aureus</i> (MRSA) Infection
Authors: Renée L. Tonkin, Anna Klöckner, Adrian Najer, Carolina J. Simoes da Silva, Cécile Echalier, Marc S. Dionne, Andrew M. Edwards, Molly M. Stevens
Journal: Advanced Healthcare Materials (2022)

Antibiotic resistance is a severe global health threat and hence demands rapid action to develop novel therapies, including microscale drug delivery systems. Herein, a hierarchical microparticle system is developed to achieve bacteria-activated single- and dual-antibiotic drug delivery for preventing methicillin-resistant Staphylococcus aureus (MRSA) bacterial infections. The designed system is based on a capsosome structure, which consists of a mesoporous silica microparticle coated in alternating layers of oppositely charged polymers and antibiotic-loaded liposomes. The capsosomes are engineered and shown to release their drug payloads in the presence of MRSA toxins controlled by the Agr quorum sensing system. MRSA-activated single drug delivery of vancomycin and synergistic dual delivery of vancomycin together with an antibacterial peptide successfully kills MRSA in vitro. The capability of capsosomes to selectively deliver their cargo in the presence of bacteria, producing a bactericidal effect to protect the host organism, is confirmed in vivo using a Drosophila melanogaster MRSA infection model. Thus, the capsosomes serve as a versatile multidrug, subcompartmentalized microparticle system for preventing antibiotic-resistant bacterial infections, with potential applications to protect wounds or medical device implants from infections.
Designing Cures 2.0 — From Corridors to Cornerstones
Authors: Kushal T. Kadakia, Harlan M. Krumholz
Journal: New England Journal of Medicine (2022)

Interview with Kushal Kadakia on the 21st Century Cures Act, Cures 2.0, and lessons from Covid-19 for medical product development. (11:29)Download The Cures 2.0 Act represents an opportunity to advance policies that encourage the use of digital tools, incorporate more efficient and patient-centered research designs, and clarify expectations for evidence generation throughout the life cycle of medical products.
Association of School Education With Eyesight Among Children and Adolescents
Authors: Chunfeng Zhang, Ling Li, Catherine Jan, Xiang Li, Jia Qu
Journal: JAMA Network Open (2022)

<h3>Importance</h3> Myopia in youths is an increasingly common global problem, associated with significant social and economic burden worldwide. <h3>Objectives</h3> To explore the association of school education with myopia and investigate its scale, controlling confounding factors, such as age and socioeconomic status. <h3>Design, Setting, and Participants</h3> This cross-sectional study was conducted from July 2019 to December 2020 using regression discontinuity (RD) based on the Compulsory Education Law to examine the complex association of school education with myopia. Participants were youths from grades 1 to 12 before tertiary or university studies in China, including individuals from 815 primary schools, 373 junior high schools, and 145 senior high schools. Data were analyzed from February through June 2021. <h3>Exposures</h3> Participants born earlier in a year (ie, January to August) were assigned 1 more year of education and were considered to be in the treated group, while participants born September to December were considered to be in the control group. <h3>Main Outcomes and Measures</h3> Differences in mean spherical equivalent refractive error (MSE) and uncorrected visual acuity (UVA) between treated and control groups were calculated. <h3>Results</h3> Among a mean (SD) of 812 979 (55 953) participants across 5 surveys survey (mean SD 44.9% [0.5%] female participants; mean [SD] age, 11.19 [2.60] years), the mean (SD) MSE was −1.30 (2.93) diopters and mean (SD) UVA was 4.77 (0.34) points. Every additional year at school was associated with an decrease in MSE of −0.17 diopters/y (95% CI, −0.22 to −0.11 diopters/y) and a decrease in UVA of −0.03 points/y (95% CI, −0.04 to −0.02 points/y), which accounts for nearly 66.4% (95% CI, 85.9% to 43.0%) and 78.9% (95% CI, 102.6% to 55.3%) of changes of MSE and UVA, respectively, among all factors for youths. The greatest MSE shifts occurred in grades 3 and 7 (eg, for the June 2019 census, the RD was −0.26 diopters/y [95% CI, −0.33 to −0.20 diopters/y] for grade 3 and −0.41 diopters/y [95% CI, −0.66 to −0.15 diopters/y] for grade 7). <h3>Conclusions and Relevance</h3> These findings suggest that receiving more years of education, instead of age, may be a risk factor associated with myopia progression in youths.
Diet or medication in primary care patients with IBS: the DOMINO study - a randomised trial supported by the Belgian Health Care Knowledge Centre (KCE Trials Programme) and the Rome Foundation Research Institute
Authors: Florencia Carbone, Karen Van den Houte, Linde Besard, Céline Tack, Joris Arts, Philip Caenepeel, Hubert Piessevaux, Alain Vandenberghe, Christophe Matthys, Jessica Biesiekierski, Luc Capiau, Steven Ceulemans, Olivier Gernay, Lydia Jones, Sophie Maes, Christian Peetermans, Willem Raat, Jeroen Stubbe, Rudy Van Boxstael, Olivia Vandeput, Sophie Van Steenbergen, Lukas Van Oudenhove, Tim Vanuytsel, Michael Jones, Jan Tack
Journal: Gut (2022)

Background In Europe, IBS is commonly treated with musculotropic spasmolytics (eg, otilonium bromide, OB). In tertiary care, a low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet provides significant improvement. Yet, dietary treatment remains to be explored in primary care. We evaluated the effect of a smartphone FODMAP-lowering diet application versus OB on symptoms in primary care IBS. Methods IBS patients, recruited by primary care physicians, were randomised to 8 weeks of OB (40 mg three times a day) or diet and followed for 24 weeks. We compared IBS Symptom Severity Score and the proportion of responders (improvement ≥50 points) in all patients and the subgroup fulfilling Rome IV criteria (Rome+). We also evaluated treatment efficacy, quality of life, anxiety, depression, somatic symptom severity (Patient Health Questionnaire (PHQ15, PHQ9)) and treatment adherence and analysed predictors of response. Results 459 primary care IBS patients (41±15 years, 76% female, 70% Rome+) were randomised. The responder rate after 8 weeks was significantly higher with diet compared with OB (71% (155/218) vs 61% (133/217), p=0.03) and more pronounced in Rome+ (77% (118/153) vs 62% (98/158), p=0.004). Patients allocated to diet (199/212) were 94% adherent compared with 73% with OB (148/202) (p&lt;0.001). The significantly higher response rate with diet was already observed after 4 weeks (62% (132/213) vs 51% (110/215), p=0.02) and a high symptom response persisted during follow-up. Predictors of response were female gender (OR=2.08, p=0.04) for diet and PHQ15 (OR=1.10, p=0.02) for OB. Conclusion In primary care IBS patients, a FODMAP-lowering diet application was superior to a spasmolytic agent in improving IBS symptoms. A FODMAP-lowering diet should be considered the first-line treatment for IBS in primary care. Trial registration number NCT04270487 .
Genomic selection and genetic architecture of agronomic traits during modern rapeseed breeding
Authors: Jihong Hu, Biyun Chen, Jing Zhao, Fugui Zhang, Ting Xie, Kun Xu, Guizhen Gao, Guixin Yan, Hongge Li, Lixia Li, Gaoxiang Ji, Hong An, Hao Li, Qian Huang, Meili Zhang, Jinfeng Wu, Weilin Song, Xiaojun Zhang, Yujie Luo, J. Chris Pires, Jacqueline Batley, Shilin Tian, Xiaoming Wu
Journal: Nature Genetics (2022)
Laparoscopic anatomical versus non-anatomical liver resection for hepatocellular carcinoma located in the posterosuperior segments of the liver: A propensity score matched analysis
Authors: Jai Young Cho, Boram Lee, Ho-Seong Han, Yoo-Seok Yoon, Hae Won Lee, Jun Suh Lee, Moonhwan Kim, Yeongsoo Jo Jo
Journal: International Journal of Surgery (2022)
Neuroscience Advances and the Developmental Origins of Health and Disease Research
Authors: Catherine Monk, Cristina R. Fernández
Journal: JAMA Network Open (2022)

Yao Wu, PhD; Kristina M. Espinosa, PsyD; Scott D. Barnett, PhD; Anushree Kapse, MBA; Jessica Lynn Quistorff, MPH; Catherine Lopez, MS; Nickie Andescavage, MD; Subechhya Pradhan, PhD; Yuan-Chiao Lu, PhD; Kushal Kapse, MS; Diedtra Henderson, BA; Gilbert Vezina, MD; David Wessel, MD; Adré J. du Plessis, MBChB; Catherine Limperopoulos, PhD
Total mesopancreas excision in pancreaticoduodenectomy for pancreatic head cancer. Impact on the superior mesenteric artery margin status
Authors: Alejandro Serrablo-Requejo, Sandra Paterna-López, Marta Gutiérrez-Díez, María Teresa Abadía, Mario Serradilla-Martín, Pablo Sancho-Pardo, Consuelo Artigas-Marco
Journal: International Journal of Surgery (2022)
Prevalence and factors associated with long-term remission in cutaneous lupus: A longitudinal cohort study of 141 cases
Authors: Damien Fayard, Camille Francès, Zahir Amoura, Paul Breillat, Alexis Mathian, Patricia Senet, Annick Barbaud, Laurent Arnaud, François Chasset
Journal: Journal of the American Academy of Dermatology (2022)
Multimodal Approach in the Diagnosis of Hippel – Lindau Disease. Case Report
Authors: D. S. Stegura, R. N. Konovalov, M. V. Krotenkova, M. V. Dreval’, P. L. Anufriev, A. N. Kovaleva, D. D. Kuryshev
Journal: Radiology - Practice (2022)

Hippel-Lindau disease is a rare hereditary combined pathology characterized by development of a variety of benign and malignant tumors in the central nervous system, kidneys, pancreas, adrenal glands, which causes a wide range of clinical manifestations. A comprehensive diagnostic approach using various imaging techniques such as ultrasound, magnetic resonance imaging, computed tomography, and genetic testing is an integral part of successful treatment.
A tailored approach for the treatment of hepatocellular carcinoma within Milan criteria developed on advanced fibrosis/cirrhosis by multibipolar radiofrequency ablation or liver resection
Authors: Francois Cauchy, Agnes Rode, Alexis Laurent, Louise Barbier, Chetana Lim, Lilian Schwarz, Christophe Aubé, Olivier Soubrane, Olivier Seror, Jean-Charles Nault
Journal: International Journal of Surgery (2022)
Duo Cadherin‐Functionalized Microparticles Synergistically Induce Chondrogenesis and Cartilage Repair of Stem Cell Aggregates
Authors: Xueping Wang, Xingquan Xu, Yan Zhang, Xueying An, Xue Zhang, Guoqiang Chen, Qing Jiang, Jun Yang
Journal: Advanced Healthcare Materials (2022)

Mesenchymal stem cell (MSC) aggregates incorporated with microparticles of functional materials have shown promising prospects in the field of cell therapy for cartilage repair. Given the importance of cadherins in modulating the stemness and chondrogenesis of MSCs, the use of transforming growth factor β1 (TGFβ1)-loaded poly (lactic-co-glycolic acid) (PLGA)-based composite microparticles inspired by duo cadherin (human E- and N-cadherin fusion proteins) to construct a bioartificial stem cell niche in engineered human MSC (hMSC) aggregates to promote chondrogenesis and cartilage regeneration is proposed. The hE/N-cadherin-functionalized PLGA/chitosan-heparin-TGFβ1 (Duo hE/N-cad@P/C-h-TGFβ1) microparticles spatiotemporally upregulates the endogenous E/N-cadherin expression of hMSC aggregates which further amplifies the chondrogenic differentiation and modulate paracrine and anti-inflammatory functions of hMSCs toward constructing a favorable microenvironment for chondrogenesis. The Duo hE/N-cad@P/C-h-TGFβ1 microparticles finely regulate the response of hMSCs to biochemical and mechanical signal stimuli in the microenvironment through the cadherin/catenin-Yes-associated protein signal transduction, which inhibits the hypertrophy of hMSC-derived chondrocytes. Furthermore, immunofluorescent and histological examinations show that the Duo hE/N-cad@P/C-h-TGFβ1 microparticles significantly improve regeneration of cartilage and subchondral bone in vivo. Together, the application of duo cadherin-functionalized microparticles is considered an innovative material-wise approach to exogenously activate hMSC aggregates for functional applications in regenerative medicine.
Progressive increase in time to referral and persistently severe clinical presentation over the years in autoantibody-negative patients with rheumatoid arthritis in the setting of an early arthritis clinic
Authors: Ludovico De Stefano, Bernardo D’Onofrio, Garifallia Sakellariou, Antonio Manzo, Carlomaurizio Montecucco, Serena Bugatti
Journal: Annals of the Rheumatic Diseases (2022)
Some forgotten issues in sleep apnoea
Authors: Miguel Ángel Martínez-García, Patrick Lévy
Journal: European Respiratory Journal (2022)

<b>This editorial deals with a series of papers on major issues in sleep apnoea. Sleep apnoea in heart failure and during ageing is a growing concern. More evidence is needed regarding management, particularly on drug treatments and stimulation techniques.</b>https://bit.ly/3iHr5bi
Bamboo‐Based Biomaterials for Cell Transportation and Bone Integration
Authors: Jianmin Xue, Hongshi Ma, Erhong Song, Fei Han, Tian Li, Meng Zhang, Yufang Zhu, Jianjun Liu, Chengtie Wu
Journal: Advanced Healthcare Materials (2022)

The construction of hierarchical porous structure in biomaterials is of great significance for improving nutrient transport and biological performance. However, it is still challenging to design porous bone substitutes with high strength and biological properties, which limits their clinical applications in load-bearing bone regeneration. Herein, based on hierarchical porous structure of renewable bamboo, the mineralized calcium phosphate/bamboo composite scaffolds with high strength and excellent transport performance are successfully prepared in combination of biotemplated approach and biomimetic mineralization. The mineralized biomaterials have simultaneously achieved high mechanical strength and low modulus, similar to those of cortical bone. Furthermore, the mineralized biomaterials exhibit good liquid transport capacity and can transport cells along anti-gravity direction. Based on density functional theory (DFT) calculations, the mineralized calcium phosphate reveals the optimal H2 O adsorption energy (-0.651 eV) and low diffusion energy barrier (0.743 eV), which is conducive to enhance hydrophilicity and liquid transport performance. Moreover, owing to the synergistic effect of the porous structure of biotemplate and bioactive mineralized components, the mineralized biomaterials possess enhanced bone integration and osteoconduction properties. The present study shed light on deeper understanding of mineralized biosourced materials, offering a strategy of combining green chemistry with tissue engineering to prepare eco-friendly biomaterials.
Annals Story Slam - Papa Is on a Ventilator
Authors: Andrea Anampa-Guzmán
Journal: Annals of Internal Medicine (2022)

Web ExclusivesJune 2022Annals Story Slam - Papa Is on a VentilatorFREEAndrea Anampa-GuzmánAndrea Anampa-GuzmánUniversidad Nacional Mayor de San Marcos, Lima, Peru (A.A.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/W22-0002 SectionsAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Video. Annals Story Slam - Papa Is on a Ventilator "Papa Is on a Ventilator," by Dr. Andrea Anampa-GuzmGuzmánn (Duration 2:48)Building on the popular Annals feature “On Being a Doctor,” storytellers share stories about the experience of doctoring on video.For more videos from and information on Annals Story Slam, visit go.annals.org/StorySlam. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: Universidad Nacional Mayor de San Marcos, Lima, Peru (A.A.)Corresponding Author: Andrea Anampa-Guzmán; e-mail, andrea.[email protected]com.pe.This article was published at Annals.org on 29 April 2022. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics June 2022Volume 175, Issue 6Page: SS1 ePublished: 29 April 2022 Issue Published: June 2022 CopyrightCopyright © 2022 by American College of Physicians. All Rights Reserved.Loading ...
Acute Hepatitis and Adenovirus Infection Among Children — Alabama, October 2021–February 2022
Authors: Julia M. Baker, Markus Buchfellner, William Britt, Veronica Sanchez, Jennifer L. Potter, L. Amanda Ingram, Henry Shiau, Luz Helena Gutierrez Sanchez, Stephanie Saaybi, David Kelly, Xiaoyan Lu, Everardo M. Vega, Stephanie Ayers-Millsap, Wesley G. Willeford, Negar Rassaei, Hannah Bullock, Sarah Reagan-Steiner, Ali Martin, Elizabeth A. Moulton, Daryl M. Lamson, Kirsten St. George, Umesh D. Parashar, Aron J. Hall, Adam MacNeil, Jacqueline E. Tate, Hannah L. Kirking
Journal: MMWR Morbidity and Mortality Weekly Report (2022)

During October-November 2021, clinicians at a children's hospital in Alabama identified five pediatric patients with severe hepatitis and adenovirus viremia upon admission. In November 2021, hospital clinicians, the Alabama Department of Public Health, the Jefferson County Department of Health, and CDC began an investigation. This activity was reviewed by CDC and conducted consistent with applicable federal law and CDC policy.
The prognostic factors of patients with hepatorenal syndrome following adult living donor liver transplantation
Authors: Cheon-Soo Park, Yong-Pil Cho, Shin Hwang, Chul-Soo Ahn, Deok-Bog Moon, Ki-Hun Kim, Gi-Won Song, Dong-Hwan Jung, Gil-Chun Park, Sung-Gyu Lee
Journal: International Journal of Surgery (2022)
Red cell distribution in critically ill patients with chronic obstructive pulmonary disease
Authors: W. Lan, E. Liu, D. Sun, W. Li, J. Zhu, J. Zhou, M. Jin, W. Jiang
Journal: Pulmonology (2022)

Red blood cell distribution width (RDW) is associated with increased mortality risk in patients with chronic obstructive pulmonary disease (COPD). However, limited data are available for critically ill patients with COPD.
Annals Story Slam - I Know Them by Name
Authors: Rashona A. Moss
Journal: Annals of Internal Medicine (2022)

Web ExclusivesJune 2022Annals Story Slam - I Know Them by NameFREERashona A. Moss, DORashona A. Moss, DOSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/W22-0006 SectionsAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Video. Annals Story Slam - I Know Them by Name "I Know Them by Name," by Dr. Rashona A. Moss (Duration 2:52)Building on the popular Annals feature “On Being a Doctor,” storytellers share stories about the experience of doctoring on video.For more videos from and information on Annals Story Slam, visit go.annals.org/StorySlam. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: Corresponding Author: Rashona A. Moss, DO; e-mail, [email protected]com.This article was published at Annals.org on 29 April 2022. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics June 2022Volume 175, Issue 6Page: SS1 ePublished: 29 April 2022 Issue Published: June 2022 CopyrightCopyright © 2022 by American College of Physicians. All Rights Reserved.Loading ...
Association between SARS‐COV‐2 infection and muscle strain injury occurrence in elite male football players: a prospective study of 29 weeks including three teams from the Belgian professional football league
Authors: Evi Wezenbeek, Sander Denolf, Tine Marieke Willems, Dries Pieters, Jan G Bourgois, Renaat M Philippaerts, Bram De Winne, Matthias Wieme, Robbe Van Hecke, Laurence Markey, Joke Schuermans, Erik Witvrouw, Steven Verstockt
Journal: British Journal of Sports Medicine (2022)

The aim of this study was to investigate the association between SARS-CoV-2 infection and muscle strain injury in elite athletes.
Liver transplantation for hepatocellular carcinoma: Extended Malatya criteria
Authors: Volkan Ince, Brian I. Carr, Harika G. Bag, Veysel Ersan, Sertac Usta, Cemalettin Koc, Serdar Karakas, Baris Sarici, Fatih Gonultas, Sezai Yilmaz
Journal: International Journal of Surgery (2022)
Successful extracorporeal membrane oxygenation therapy as a bridge to liver transplantation for acute respiratory distress syndrome-induced life-threatening hypoxemia aggravated by end-stage liver disease: Two case reports
Authors: Tae Beom Lee, Hyojeong Ko, Jae Ryong Shim, Byung Hyun Choi, Kwangho Yang, Je Ho Ryu
Journal: International Journal of Surgery (2022)