tbuckley/cabot-search huggingface dataset:
Stimulation of renin release by hyperoncotic perfusion of the isolated rat kidney.
Authors: A JCohen, KSpokes, R SBrown, J SStoff, PSilva
Journal: Circulation Research (1982)

Renin release was measured in the isolated rat kidney perfused with a recirculating artificial medium containing bovine serum albumin at 6.7 g per 100 ml of 11 g per 100 ml. At the higher concentration of albumin, glomerular filtration ceased and the rate of renin release over 70 minutes of perfusion was increased 6-fold. The addition of ouabain to the perfusate containing 11 g per 100 ml inhibited the release of renin, suggesting that inhibition of Na-K-ATPase or the related changes in cellular volume or composition prevented renin release. Lowering the osmolality of the perfusate by reducing the concentration of sodium chloride also prevented the increase in renin secretion produced by perfusion with 11 g per 100 ml albumin. Increasing the osmolality of the perfusate with mannitol restored the augmented renin release. These results are consistent with the hypothesis that alterations in the volume of certain cells, perhaps in the juxtaglomerular apparatus itself, can control renin release.
Deficient acceleration of left ventricular relaxation during exercise after heart transplantation.
Authors: W JPaulus, J GBronzwaer, HFelice, NKishan, FWellens
Journal: Circulation (1992)

BACKGROUNDThe exercise-induced rise in left ventricular filling pressures after cardiac transplantation is considered to be the result of a blunted heart rate response, of elevated venous return, and of unfavorable passive late-diastolic properties of the cardiac allograft. In contrast to passive late-diastolic left ventricular properties, the effect of left ventricular relaxation on the exercise-induced rise in left ventricular filling pressures of the cardiac allograft has not yet been studied. In the present study, the response of left ventricular relaxation to exercise was investigated in transplant recipients and compared with left ventricular relaxation observed in normal control subjects exercised to the same heart rate. Moreover, the response of left ventricular relaxation of the cardiac allograft to beta-adrenoreceptor stimulation, to reduced left ventricular afterload, and to increased myocardial activator calcium was investigated by infusion of dobutamine and of nitroprusside and by postextrasy...
Outcomes of Graft Failures after Umbilical Cord Blood Transplantation in Acute Leukemia: A Study from Eurocord and the Acute Leukemia Working Party of the EBMT
Authors: Frederic Baron, Annalisa Ruggeri, Eric Beohou, Myriam Labopin, Mohamad Mohty, Jaime Sanz, Riccardo Saccardi, Patrice Chevallier, Mauricette Michallet, Jean-Henri Bourhis, Christelle M Ferra Coll, William Arcese, Eliane Gluckman, Arnon Nagler
Journal: Blood (2017)
Contrasting effects of the intermittent and continuous administration of heparin in experimental restenosis.
Authors: E REdelman, M JKarnovsky
Journal: Circulation (1994)

BACKGROUNDHeparin inhibits proliferation of smooth muscle cells in culture and intimal hyperplasia in experimental animals but paradoxically exacerbates vascular injury in clinical trials. To determine whether the difference in the means by which heparin was administered explained the benefit in animals and aggravation in humans, we examined the vascular effects of a range of heparin treatments.METHODS AND RESULTSWhen laboratory rats were injected subcutaneously with heparin (55.5 IU, approximately 1.0 mg/kg) per clinical trial protocols, intimal hyperplasia after arterial injury was exacerbated rather than alleviated. The intima to media area ratio was increased 22.5% with every-other-day injections and was increased 16.8% with daily injections. When the daily dose of heparin was increased to 7.2 mg/kg or when injections were initiated a week before injury, intimal hyperplasia was made even worse (52.2% and 59.9% above control). Twice-daily heparin, 7 and 17 hours apart, had no demonstrable effect one wa...
Predictive implications of stress testing. Follow-up of 2700 subjects after maximum treadmill stress testing.
Authors: M HEllestad, M KWan
Journal: Circulation (1975)

Follow-up data on 2700 subjects who had had maximum stress tests were assembled in life tables. A positive test, characterized by ST-segment depression of 1.5 mm, 0.08 sec from the J point, predicted an incidence of some new coronary event of 9.5% a year, as compared with 1.7% in those with a negative test. The incidence of infarction and death was also significantly higher than in the negative responders. Early onset of ischemia occurring at moderate exercise (4 metabolic equivalents-METS) resulted in an incidence of all coronary events of 15% a year, while ischemia first manifested at the seventh minute of exercise (approximately 8 METS) results in an incidence of only 4% per year. The magnitude of ST depression and the age of onset of ischemia failed to influence the incidence of coronary events. A myocardial infarction previous to the test increased the incidence of events in both positive and negative responders. The positives with a previous infarction had more than double the incidence of coronary ...
Community Transmission of SARS-CoV-2 Associated with a Local Bar Opening Event — Illinois, February 2021
Authors: Samira Sami, Caitlin R. Turbyfill, Shelby Daniel-Wayman, Stacy Shonkwiler, Kiva A. Fisher, Macey Kuhring, Aaron M. Patrick, Stephanie Hinton, Amanda S. Minor, Jessica N. Ricaldi, Ngozi Ezike, Judy Kauerauf, Wayne A. Duffus
Journal: MMWR Morbidity and Mortality Weekly Report (2021)

Forty-six cases of COVID-19 were linked to an indoor bar opening event that occurred during February 2021 in a rural Illinois county. Event patrons were linked to secondary cases among household, long-term care facility, and school contacts.
Abstract 19530: Functional Assessment of Coronary Artery Disease Using Low-dose Dynamic Computed Tomography Perfusion
Authors: LoganHubbard, BenjaminZiemer, JerryLipinski, BahmanSadeghi, HannaJavan, E MGroves, SabeeMolloi
Journal: Circulation (2015)

Introduction: Computed tomographic angiography (CTA) is, despite its limitations, a powerful modality for noninvasive assessment of coronary artery disease (CAD). Current dynamic CT perfusion (CTP) techniques aim to improve CAD assessment, but deliver high radiation doses, limiting their clinical feasibility. Therefore, we propose a low-dose, dynamic CTP technique that allows for vessel-specific, functional assessment of CAD. Methods: A coronary angioplasty balloon was advanced into the proximal left anterior descending (LAD) coronary artery of seven swine (35-45 kg) to induce several levels of stenosis at maximal hyperemia (IC adenosine, 240 μg/min). Reference fluorescence microspheres and IV contrast (370 mg/mL iodine, 25 mL, 7 mL/s) were injected and prospective, ECG-gated dynamic CTP was performed using a 320-slice CT scanner at 100 kVp and 200 mA. Twenty volume scans were acquired per stenosis level for dose comparison to current techniques, but only two volume scans, denoted as V1 and V5, were used ...
1P Real-world frequency of non-small cell lung cancer with epidermal growth factor receptor (EGFR) exon 20 insertion (Exon20ins) mutations by site of insertion
Authors: S. Viteri, J.M. Bauml, L. Bazhenova, S-H.I. Ou, N. Girard, M. Schaffer, J. Rose, J. Curtin, J. Karkera, P. Mahadevia, A.R. Minchom
Journal: Journal of Thoracic Oncology (2021)
Comprehensive clinical electrophysiologic studies in the investigation of documented or suspected tachycardias. Time, staff, problems and costs.
Authors: D LRoss, JFarre, F WBar, E JVanagt, W RDassen, IWiener, H JWellens
Journal: Circulation (1980)

To assess time, staff, problems and costs involved in clinical electrophysiologic studies for documented or suspected tachycardia, 33 consecutive cases were analyzed prospectively. At least seven staff members were used for each study. Insertion of catheters required 24--105 minutes (mean 63 +/- 20 minutes). Programmed stimulation required 12--210 minutes (mean 87 +/- 38 minutes). Total fluoroscopy times were 6--67 minutes (mean 22 +/- 15 minutes). Each study used 360--2100 feet (mean 1260 +/- 390 feet) of recording paper. Detailed analysis of tracing took 1--11 hours (mean 5 +/- 2.5 hours). Delays occurred during electrophysiologic study in 25 cases (76%), with multiple causes of delay in 14 cases (42%). These were caused by 1) difficulty in obtaining venous access (five patients); 2) difficult initial catheter placement (15 cases); 3) repositioning of catheters during stimulation (17 cases); 4) sustained atrial fibrillation (four cases). Coronary sinus catheterization was achieved from the groin in 21 o...
Alterations in aldosterone biosynthesis in essential hypertensives.
Authors: B FDawson-Hughes, T JMoore, R GDluhy, SPodolsky, G HWilliams
Journal: Circulation Research (1981)

We studied hypertensives with decreased adrenal responsiveness to infused angiotensin II (AII) to assess their responsiveness to other aldosterone secretagogues, ACTH and potassium, which are thought to stimulate aldosterone synthesis in sites different from one another and from AII. All subjects, following sodium restriction, received an infusion of AII in increasing doses (0.1-3 ng/kg per min). The increment in aldosterone between control and the highest infusion dose divided by the increment in plasma AII was used as the index of adrenal responsiveness. All normotensive controls (NC) had a ratio greater than 0.5. Hypertensives with a normal ratio were designated normal responders (NR) and those with a lower ratio were abnormal responders (AbR). The slope of the regression line between aldosterone and AII was significantly less for the AbR (0.02 +/- 0.04) than for the NR (1.20 +/- 0.02, P less than 0.001) and the NC (1.00 +/- 0.03, P less than 0.001) groups. During infusion of cosyntropin in increasing ...
Re: ʻDevelopment of diagnostic prediction tools for bacteraemia caused by 3rd generation cephalosporin-resistant Enterobacteriaceae in suspected bacterial infectionsʼ by Rottier, et al.
Authors: M.M.C. Lambregts, A.T. Bernards, L.G. Visser, M.G.J. de Boer
Journal: Clinical Microbiology and Infection (2018)
Contractile deactivation and uncoupling of crossbridges. Effects of 2,3-butanedione monoxime on mammalian myocardium.
Authors: J KGwathmey, R JHajjar, R JSolaro
Journal: Circulation Research (1991)

We investigated the effects of 1 and 3 mM 2,3-butanedione monoxime (BDM, diacetyl monoxime) on excitation and contraction of cardiac muscle in several types of preparations at various levels of organization. We selected a concentration of BDM that was not expected to affect sarcolemmal calcium flux and action potential duration in cardiac tissue. Two indicators were used to record intracellular calcium. Aequorin, a bioluminescent calcium indicator, was used in studies with ferret papillary muscle preparations, and fura-2, a fluorescent calcium indicator, was used in studies with guinea pig cardiac myocytes. In both cases, addition of BDM resulted in a reduction of peak intracellular calcium released from the sarcoplasmic reticulum and a reduction of peak twitch force. The duration of the action potential of isolated myocytes was slightly abbreviated in the presence of BDM. In studies on the calcium current in the myocytes, addition of BDM was associated with reduced calcium current at any potential. Peak ...
Interventricular coronary steal induced by stenosis of left anterior descending coronary artery in exercising pigs.
Authors: A JCrottogini, B DGuth, J GBarra, PWillshaw, E CLascano, R HPichel
Journal: Circulation (1991)

BACKGROUNDIn pigs and humans, the left anterior descending coronary artery (LAD) supplies the left ventricular anterior wall (LVAW), anterior septum, and paraseptal band of the right ventricular anterior wall (RVAW). The purposes of our study were 1) to study the LAD flow distribution in these walls during preexercise, exercise, and exercise with LAD stenosis and 2) to analyze regional wall motion under these conditions.METHODS AND RESULTSNine pigs were instrumented with sonomicrometers for measuring percent wall thickening (%WTh) in LVAW, RVAW, and lateral (control) walls of both ventricles, a hydraulic occluder at the LAD origin, an LV pressure transducer, and catheters for radioactive microsphere injection (left atrium) and blood withdrawal (aorta). One month later, regional %WTh and flows were measured during preexercise, exercise, and continuing exercise with LAD stenosis resulting in more than 50% reduction in systolic LVAW %WTh with regard to exercise. LAD stenosis caused a dramatic decrease in tot...
Renal responses of the fetal lamb to fetal or maternal volume expansion.
Authors: J KHurley, S EKirkpatrick, P TPitlick, W FFriedman, S AMendoza
Journal: Circulation Research (1977)

Fetal and maternal glomerular filtration rate (GFR), renal plasma flow (RPF), urine volume, sodium excretion, and fractional sodium reabsorption were measured in a chronically instrumented sheep preparation. Fetal GFR was essentially stable between 110 and 135 days of gestation (term = 147 days). There was a significant increase in GFR after 135 days. After the infusion of 50 ml of normal saline over a 30-minute period, fetal GFR and sodium excretion increased significantly. Fractional sodium reabsorption was significantly decreased. Thus, the fetus is capable of responding to volume expansion with saline with an increase in GFR and a decrease in fractional sodium reabsorption. After the infusion of 1000 ml of normal saline into the ewe in 1 hour, maternal GFR and RPF rose significantly. Sodium excretion rose 6-fold and fractional sodium reabsorption fell significantly. After the infusion of saline into the ewe, there was no change in fetal GFR, RPF, sodium excretion, urine volume, or fractional sodium re...
Significance of sodium, sympathetic innervation, and central adrenergic structures on renal vascular responsiveness in DOCA-treated rats.
Authors: K HBerecek, R DMurray, FGross
Journal: Circulation Research (1980)

The effects of sodium, sympathetic innervation, and central adrenergic structures on the development of changes in renal vascular reactivity were studied in unilaterally nephrectomized rats treated with a single implant of deoxycorticosterone acetate (DOCA; 100 mg/kg). Vascular reactivity to norepinephrine (NE) and vasopressin (ADH) was assessed in isolated kidneys perfused with a synthetic medium. Influence of sodium was determined by placing DOCA-treated rats on high, normal, and low sodium intakes. Neural influence was studied by means of local denervation of the renal artery and by intravenous (iv) and intraventricular (ivt) administration of 6-hydroxydopamine (6-OHDA). Marked changes in renal vascular reactivity in DOCA-treated rats were already apparent prior to the rise in blood pressure. Dose-response curves for NE and ADH showed parallel leftward shifts and decreased threshold doses. Normal sodium intake, local denervation, and peripheral sympathectomy had no effect on the development of these va...
Second-line FOLFOX chemotherapy versus active symptom control for advanced biliary tract cancer (ABC-06): a phase 3, open-label, randomised, controlled trial
Authors: Angela Lamarca, Daniel H Palmer, Harpreet Singh Wasan, Paul J Ross, Yuk Ting Ma, Arvind Arora, Stephen Falk, Roopinder Gillmore, Jonathan Wadsley, Kinnari Patel, Alan Anthoney, Anthony Maraveyas, Tim Iveson, Justin S Waters, Claire Hobbs, Safia Barber, W David Ryder, John Ramage, Linda M Davies, John A Bridgewater, Juan W Valle
Journal: The Lancet Oncology (2021)

Advanced biliary tract cancer has a poor prognosis. Cisplatin and gemcitabine is the standard first-line chemotherapy regimen, but no robust evidence is available for second-line chemotherapy. The aim of this study was to determine the benefit derived from second-line FOLFOX (folinic acid, fluorouracil, and oxaliplatin) chemotherapy in advanced biliary tract cancer.
A novel monitor for practical brain-computer interface applications based on visual evoked potential
Authors: Hamidreza Maymandi, Jorge Luis Perez Benitez, F. Gallegos-Funes, J. A. Perez Benitez
Journal: Brain-Computer Interfaces (2021)

This study proposes and evaluates a novel monitor for generating visual-evoked potential (VEP) for daily use brain–computer interface (BCI) applications. The backlight of a conventional monitor was replaced with a matrix panel of LEDs to take maximum advantage of both the computer monitor and LED in generating VEP. This matrix contains 32 cells working independently at an adjustable range of flickering frequencies. The software was further developed to control the number of cells as needed. Thanks to this design, the monitor can work simultaneously as a conventional monitor and as a high-frequency visual stimulator. In total, this monitor provides up to 32 targets at all ranges of frequencies. The proposed monitor exhibits high performance in generating stable high-frequency VEP(34Hz-49.5Hz). This feature allows the monitor to cope with the main deficiencies of BCI devices such as the low number of targets, low-frequency stimulation, and lack of implementing an integrated system.
The Reduction Of Patients Visiting The Emergency Surgical Department Of A Tertiary General Hospital Of Athens In The Period Of Covid-19 Lockdown Forced In Greece
Authors: K Tsekouras, G Karlis, S Orfanos, G Tsitsinakis
Journal: Endoscopy (2021)

Aims A full lockdown was forced in Greece due to the COVID-19 pandemic for 53 days and specifically from 03/13/2020 to 05/04/2020. The objective of this study was to assess the impact of lockdown on the number of patients visiting the Emergency Surgical Department (ESD) of a tertiary Greek hospital. It is common sense that the vast majority of patients examined in the ESDs have no symptoms related to SARS-CoV-2.
Hypertensive heart disease in African-Americans.
Authors: D DSavage
Journal: Circulation (1991)

Hypertensive heart disease is a frequent complication in hypertensive African-Americans because of inadequate high blood pressure control. Moreover, African-Americans may be predisposed to develop LVH earlier in life and more readily than Caucasians, and it may be more malignant. The appearance of both LVH and congestive heart failure are ominous developments in individual patients, and early detection of LVH is mandatory for adequate management and reversal of this complication, if possible. Additional research is needed, and new, sensitive tools for detecting LVH will accelerate such studies. Further investigations are also needed on the reversibility of LVH, preferred antihypertensive agents for accomplishing reversal, and whether expected benefits result.
Lack of beta-adrenoreceptor hypersensitivity after abrupt withdrawal of long-term therapy with oxprenolol.
Authors: PBolli, F RBühler, E ARaeder, F WAmann, MMeier, HRogg, DBurckhardt
Journal: Circulation (1981)

The possibility of beta-adrenoreceptor hypersensitivity after abrupt withdrawal of long-term therapy (8-18 months) with the slow-release (SR) formulation of oxprenolol (160-320 mg/day) was assessed in six patients with uncomplicated essential hypertension. The chronotropic dose 25 of isoproterenol (the dose that increases the resting heart rate by 25 beats/min), plasma concentration of catecholamines, triiodothyronin and thyroxin, plasma renin activity and aldosterone, hemoglobin, hematocrit and oxyhemoglobin dissociation were measured on the last day of oxprenolol SR intake and 1, 2, 3, 6 and 13 days after abrupt replacement by identical placebo tablets. The chronotropic dose 25 of isoproterenol (microgram/m2), which was greater than 25.6 in all patients on the last day of oxprenolol SR, fell to 4.83 +/- 2.03 on the second day and to 3.50 on the third day after its abrupt withdrawal and reached a minimal value on the thirteenth day (2.78 +/- 0.30). Throughout the study, plasma concentrations of catechola...
198P Analysis of efficacy of immunotherapy according to histology in malignant pleural mesothelioma (MPM) patients
Authors: S. Cedres, J.D. Assaf, P. Iranzo, A. Callejo, N. Pardo, A. Navaro, A. Martinez-Marti, H. Bote, D. Marmolejo, J. Lostes, V. Monton, J. Gonzalo, A. Pedrola, E. Felip
Journal: Journal of Thoracic Oncology (2021)
Measurement of in vivo proliferation in human colorectal mucosa using bromodeoxyuridine
Authors: Potten, Kellett, Roberts, Rew, Wilson
Journal: Gut (1992)

In vivo bromodeoxyuridine (BrdUrd) labelling of the human large bowel was performed and a detailed histochemical localisation of label in sections of crypts was undertaken using a monoclonal antibody to BrdUrd containing DNA. Flow cytometric studies on extracted nuclei were also performed (data presented elsewhere). The average crypt in the human large bowel (excluding the rectum) was 82 cells in height and 41 cells in circumference, with a total of about 2000 cells (assuming a topographical correction factor of 0.6). Ten per cent of the cells were replicating their DNA--that is, were in the S phase of the cell cycle-- and 0.4% were in mitosis. The median position for the labelling index versus cell position frequency plot is at the 20th cell position--at a quarter of the crypt height. The lower and upper limits of the cell proliferation are given by the 5th and 95th percentiles at cell positions 4 and 43 respectively. The peak labelling index is about 30% and it occurs at cell position 15. The labelling index at the crypt base, the probable stem cell zone, is about 14%, suggesting that these cells have a longer cell cycle. Taking a value of 8.6 hours for the duration of the S phase (deduced from the flow cytometric data) and assuming a growth fraction of 1.0 for the mid-crypt, these data provide an estimate of about 30 hours for the cell cycle time. The rectal crypts are about the same size but contain about 30% fewer S phase cells. The data also yielded a per cent BrdUrd labelled mitosis curve
Continuous 12-lead ST-segment recovery analysis in the TAMI 7 study. Performance of a noninvasive method for real-time detection of failed myocardial reperfusion.
Authors: M WKrucoff, M ACroll, J EPope, C BGranger, C MO'Connor, K NSigmon, B LWagner, J ARyan, K LLee, D JKereiakes
Journal: Circulation (1993)

BACKGROUNDIf a practical, reliable, noninvasive marker of failed reperfusion was available in real time, the benefits of further therapy in this patient subgroup could be tested. We developed a method of 12-lead ST-segment recovery analysis using continuously updated reference points to provide such a marker.METHODS AND RESULTSIn this study, our method was prospectively tested in 144 patients given thrombolytic therapy early in myocardial infarction. All patients had 12-lead continuous ST-segment monitoring and acute angiography, each analyzed in an independent, blinded core laboratory. ST-segment recovery and re-elevation were analyzed up to the moment of angiography, at which time patency was predicted. Predictions were correlated to angiographic infarct artery flow, with TIMI flow 0 to 1 as occluded and TIMI flow 2 to 3 as patent. Infarct artery occlusion was seen on first injection in 27% of patients. The positive predictive value of incomplete ST recovery or ST re-elevation by our method was 71%, neg...
Response to: ‘Interleukin-36 in hidradenitis suppurativa: evidence for a distinctive proinflammatory role and a key factor in the development of an inflammatory loop’
Authors: A. Balato, G. Caiazzo, R. Di Caprio, S. Lembo, A. Raimondo, G. Monfrecola, G. Fabbrocini
Journal: British Journal of Dermatology (2017)

Linked Article:Hessam et al. Br J Dermatol 2018; 178:761–767.