tbuckley/cabot-search huggingface dataset:
AVM0703 Tumor Debulking Enhances Cy/Flu Efficacy
Authors: Theresa Deisher, Spencer Sawas, Kathleen Suwito, Colleen Rylatt, Peter A. Jarzyna, Yumna Zahid, Vaishnavi Parthasarathy, Kendra Poulin, Stephanie Lee-Diaz
Journal: Blood (2021)
Human gut bacterial metabolism drives Th17 activation and colitis
Authors: Margaret Alexander, Qi Yan Ang, Renuka R. Nayak, Annamarie E. Bustion, Moriah Sandy, Bing Zhang, Vaibhav Upadhyay, Katherine S. Pollard, Susan V. Lynch, Peter J. Turnbaugh
Journal: Cell Host & Microbe (2021)

Bacterial activation of T helper 17 (Th17) cells exacerbates mouse models of autoimmunity, but how human-associated bacteria impact Th17-driven disease remains elusive. We show that human gut Actinobacterium Eggerthella lenta induces intestinal Th17 activation by lifting inhibition of the Th17 transcription factor Rorγt through cell- and antigen-independent mechanisms. E. lenta is enriched in inflammatory bowel disease (IBD) patients and worsens colitis in a Rorc-dependent manner in mice. Th17 activation varies across E. lenta strains, which is attributable to the cardiac glycoside reductase 2 (Cgr2) enzyme. Cgr2 is sufficient to induce interleukin (IL)-17a, a major Th17 cytokine. cgr2+ E. lenta deplete putative steroidal glycosides in pure culture; related compounds are negatively associated with human IBD severity. Finally, leveraging the sensitivity of Cgr2 to dietary arginine, we prevented E. lenta-induced intestinal inflammation in mice. Together, these results support a role for human gut bacterial metabolism in driving Th17-dependent autoimmunity.
Abstract 10289: Costs of Endoscopic vs Open Vein Harvesting for Coronary Artery Bypass Grafting: Insights from the Regroup Trial
Authors: Todd Wagner, Brack Hattler, Eileen Stock, Kousick Biswas, Deepak Bhatt, Faisal Bakaeen, Marco Zenati
Journal: Circulation (2021)

Introduction: Endoscopic Vein Harvesting (EVH) provides comparable rates in major adverse cardiac events to Open Vein Harvest (OVH) based on the intermediate-term results of the REGROUP Trial. Value based purchasing places more pressure to examine whether minimally invasive techniques, e.g., EVH, yield intended or unintended economic effects. The objective of this study was to compare health care costs between participants randomized to EVH or OVH during coronary artery bypass graft (CABG) surgery in the REGROUP trial. Hypothesis: We hypothesized that EVH would result in lower discharge and follow-up costs compared to the traditional OVH. Methods: Department of Veterans Affairs Cooperative Studies Program #588 (Clinicaltrials.gov NCT01850082) randomized 1150 participants (574 OVH, 576 EVH) at 16 VA medical centers. We linked participants to VA administrative data in VA’s Corporate Data Warehouse and extracted activity-based cost data starting with the index surgery. We analyzed discharge costs for the index surgery as well as follow-up costs in 30-day periods for EVH vs. OVH, comparing results from different statistical models to test for robustness. All costs were standardized to 2020 US dollars. Results: The unadjusted average cost for CABG patients with EVH and OVH was $76,607 (SD $43,883) and $75,368 (SD $45,900), respectively; the costs include both facility and provider costs. Despite the skewed variation in costs, there were no significant differences in discharge costs and high-cost patients were equally likely in both groups. We also found no significant differences in follow-up costs; the average follow-up period was 33 months (maximum follow-up was 85 months). The results were highly robust to the statistical model. Conclusions: Endoscopic harvesting was not associated with a reduction in costs for the index CABG surgery or follow-up care, nor was it associated with increased costs through unintended events. Therefore, the choice to provide endoscopic harvesting should be based on surgeon and patient preferences.
Evolution of Late Right Heart Failure With Left Ventricular Assist Devices and Association With Outcomes
Authors: J. Eduardo Rame, Francis D. Pagani, Michael S. Kiernan, Guilherme H. Oliveira, Edo Y. Birati, Pavan Atluri, Ann Gaffey, E. Wilson Grandin, Susan L. Myers, Craig Collum, Robert L. Kormos, James K. Kirklin, Jeffrey J. Teuteberg
Journal: Journal of the American College of Cardiology (2021)
A Targetable Bone Marrow-Niche Axis for the Treatment of Acute Myeloid Leukemia
Authors: Marta Galan-Diez, Florence Borot, Abdullah M. Ali, Junfei Zhao, Eva Gil-Iturbe, Xiaochuan Shan, Xi-Ping Huang, Irwin Kurland, Bryan L. Roth, Matthias Quick, Siddhartha Mukherjee, Raul Rabadan, Martin P. Carroll, Azra Raza, Stavroula Kousteni
Journal: Blood (2021)
Abstract 14009: Longitudinal Analysis Supports Reproducibility Of Treatment With Sildenafil In The Semaxanib/Hypoxia Rat Model Of Pulmonary Arterial Hypertension
Authors: Kimberly R Doherty, Cayman A Stephen, Kyle R Siegel, Michelle M Johnson, Melissa D Zammit, Peter B Senese, Michael R Gralinski
Journal: Circulation (2021)

Rats develop translatable pulmonary arterial hypertension (PAH) after exposure to the VEGF antagonist semaxanib (SU5416) concurrent with hypoxia. Sildenafil is used clinically for PAH and as a positive control in this preclinical model. A longitudinal analysis was constructed by pooling data from discrete rat PAH studies conducted over an 8-year period to evaluate the stability and reproducibility of the SU5416/Hypoxia rodent model as well as the response to sildenafil. Sprague-Dawley rats were administered SU5416 on Day 1 and subsequently maintained in a low oxygen environment for 28 days. Sildenafil was given as a positive control in either prevention or treatment mode. Pulmonary hemodynamics were obtained on the final day as appropriate by design; hearts were also assessed for right ventricular hypertrophy. Prevention studies (≥17) were terminated following 28 days of hypoxia while most treatment studies (≥17) had a protocol-defined period of normoxia following hypoxia. In prevention studies, the mean of both systolic pulmonary arterial pressure (sPAP) and the right ventricular hypertrophy Fulton’s Index (FI) remained consistent across studies over the 7-year period: sPAP: PAH vehicle control (PAH-VC) 70 ± 19 mmHg (n = 190), sildenafil 51 ± 15 mmHg (n = 165), p&lt;.05; FI: PAH-VC 0.5573 ± 0.1048 (n = 210), sildenafil 0.4984 ± 0.1007 (n = 172), p&lt;.05. Sildenafil elicited mean reductions in sPAP of 28% and FI of 11% over the 7-year period. Mean survival rate was comparable for PAH-VC (96%) and sildenafil groups (99%).In treatment studies, the mean of both sPAP and FI remained consistent across studies over the 8-year period: sPAP: PAH-VC 89 ± 24 mmHg (n = 148) vs. sildenafil 67 ± 22 mmHg (n = 168), p&lt;.05 vs PAH-VC; FI: PAH-VC 0.5938 ± 0.0944 (n = 168) vs. sildenafil 0.5336 ± 0.1077 (n = 173), p&lt;.05 vs PAH-VC. Sildenafil elicited mean reductions in sPAP of 25% and FI of 10% over the 8-year period. Mean survival rate was comparable for PAH-VC (91%) and sildenafil groups (95%).The effects of sildenafil on reduction of PAH were stable and of similar magnitude in both prevention and treatment studies over an 8-year period. Thus, this longitudinal analysis indicates a reproducible and consistent effect of both the SU5416/Hypoxia PAH model and the use of sildenafil as a positive control.
Abstract 10371: Trajectories of Glycemic Control and Early Markers of Cardiovascular Disease in Canadian Adolescents with Type 1 Diabetes: The Cardea Study
Authors: Soren Harnois-Leblanc, Vanessa McNealis, Matthias G Friedrich, Andraea Van Hulst, Anne Monique Nuyt, Jean-Luc Bigras, Tracie A Barnett, Andrea Benedetti, Marie-Ève Mathieu, Vicky Drapeau, Marie-Pierre Sylvestre, Mélanie Henderson
Journal: Circulation (2021)

Introduction: Adequate glycemic control can prevent or delay complications of diabetes. Little is known about the role of glycemic control trajectories on early markers of CVD in youth. Hypothesis: Poor glycemic control trajectory will be associated with increased vascular ageing and altered myocardial structure. Methods: Cross-sectional study of 100 youth with T1D recruited at Sainte-Justine Hospital, Canada. Trajectories of glycated hemoglobin (Hb A1c ) were estimated with group-based trajectory modelling, using 3 to 6 values retrieved from patients’ medical records over the preceding year. Vessel stiffness was assessed by pulse-wave velocity (PWV) and distensibility by velocity time integral (VTI) and acceleration during a brachial flow-mediated dilation test. Cardiac magnetic resonance assessed ejection fraction, left ventricular mass indexed by height (LVMH), papillary mass and wall thickness. Linear regression models were estimated between Hb A1c trajectory group and each CVD marker, with age, sex, ethnicity and duration of diabetes at baseline as covariates. Results: Mean age was 16.4 yrs (SD=1.3) and median diabetes duration 6.1 yrs (IQR=3.4-10.4). Forty-eight percent were girls, 63% were White and 43% had overweight/obesity. Three trajectories of Hb A1c were identified ( Figure ). Compared with the optimal trajectory, belonging to the high Hb A1c trajectory was associated with a lower ejection fraction (beta [95% CI]: -2.1% [-6.2; 2.0]), LVMH (-6.3 g/m [-15.4; 2.8]) and papillary mass (-1.2 g [-2.2; -0.2]). Youth in the high Hb A1c trajectory displayed higher PWV (0.2 m/s [-0.4; 0.8]) and lower VTI (-2.9 cm/s 2 [-8.4; 2.7]) and acceleration (-63.6 cm/s 2 [-188.7; 61.5]) compared with the optimal trajectory group. Conclusions: Poor glycemic control is linked to increased vascular ageing and a lower myocardial mass in youth with T1D, which is consistent with our prior finding that youth with T1D exhibit a lower myocardial mass than healthy controls.
Abstract 11081: Measures of Food Inadequacy and Cardiovascular Disease Risk in Black Americans: The Jackson Heart Study
Authors: Rani Zierath, Brian Claggett, Michael E Hall, Adolfo Correa, Sharrelle Barber, Yan Gao, Sameera Talegawkar, Edith Ezekwe, Katherine L Tucker, Ana Diez-Roux, Mario Sims, Amil M Shah
Journal: Circulation (2021)

Introduction: Food insecurity is common in the U.S. and disproportionately impacts Black Americans, but its association with risk of heart failure (HF) and coronary heart disease (CHD) is unclear. We evaluated the associations of economic food insecurity and proximity to unhealthy food options with risk of incident HF and CHD, and assessed the potential impact of diet quality and stress on these associations. Methods: Among 3,024 Black adult participants in the community-based Jackson Heart Study (JHS) without prevalent HF or CHD who attended visit 1 (2000-2004), the associations of economic food insecurity (receiving food stamps, self-reported ‘not enough money for groceries’) and proximity to unhealthy food stores (&gt;2.5 unfavorable food stores [fast food restaurants, convenience stores] within 1 mile) with incident HF hospitalization and CHD were assessed using multivariable Cox proportional hazard models. Adjustment covariates included age, sex, BMI, hypertension, and diabetes in the initial model and diet quality (Healthy Eating Index) and perceived stress (total Global Perceived Stress score) in the extended model. Results: Mean age was 54±12 years, 34% were men, 630 (21%) were economically food insecure, and 1,512 (50%) had &gt;2.5 unfavorable food stores within 1 mile. In multivariable models, economic food insecurity was associated with a heightened risk of incident HF and of incident CHD, which persisted with minimal attenuation after further adjustment for diet quality and perceived stress (Table). Limited physical food access was not associated with heightened risk of incident HF or CHD after accounting for demographics. Conclusions: Economic food insecurity, but not proximity to unhealthy food options, is associated with HF and CHD risk independent of traditional cardiovascular risk factors. Increased perceived stress and worse diet quality do not appear to account for these associations.
Pain levels and associated factors in the Scleroderma Patient-centered Intervention Network (SPIN) cohort: a multicentre cross-sectional study
Authors: Yvonne C Lee, Rina S Fox, Linda Kwakkenbos, Brooke Levis, Marie-Eve Carrier, Joep Welling, Maureen Sauvé, Luc Mouthon, Andrea Benedetti, Susan J Bartlett, John Varga, Brett D Thombs, Richard S. Henry, Karen Gottesman, Marie Hudson, Laura K. Hummers, Vanessa L. Malcarne, Maureen D. Mayes, Warren R. Nielson, Robert Riggs, Shervin Assassi, Ghassan El-Baalbaki, Carolyn Ells, Kim Fligelstone, Catherine Fortuné, Tracy Frech, Amy Gietzen, Geneviève Guillot, Daphna Harel, Monique Hinchcliff, Sindhu R. Johnson, Maggie Larche, Catarina Leite, Christelle Nguyen, Karen Nielsen, Janet Pope, François Rannou, Michelle Richard, Tatiana Sofia Rodriguez-Reyna, Anne A. Schouffoer, Maria E. Suarez-Almazor, Christian Agard, Nassim Ait Abdallah, Alexandra Albert, Marc André, Elana J. Bernstein, Sabine Berthier, Lyne Bissonnette, Alessandra Bruns, Patricia Carreira, Marion Casadevall, Benjamin Chaigne, Lorinda Chung, Chase Correia, Benjamin Crichi, Christopher Denton, Robyn Domsic, James V. Dunne, Bertrand Dunogue, Regina Fare, Dominique Farge-Bancel, Paul R. Fortin, Jessica Gordon, Brigitte Granel-Rey, Genevieve Gyger, Eric Hachulla, Ariane L Herrick, Sabrina Hoa, Alena Ikic, Niall Jones, Suzanne Kafaja, Nader Khalidi, Marc Lambert, David Launay, Hélène Maillard, Nancy Maltez, Joanne Manning, Isabelle Marie, Maria Martin, Thierry Martin, Ariel Masetto, François Maurier, Arsene Mekinian, Sheila Melchor, Mandana Nikpour, Louis Olagne, Vincent Poindron, Susanna Proudman, Alexis Régent, Sébastien Rivière, David Robinson, Esther Rodriguez, Sophie Roux, Perrine Smets, Vincent Sobanski, Robert Spiera, Virginia Steen, Evelyn Sutton, Carter Thorne, Pearce Wilcox, Angelica Bourgeault, Mara Cañedo Ayala, Andrea Carboni Jiménez, Marie-Nicole Discepola, Maria Gagarine, Julia Nordlund, Nora Østbø
Journal: The Lancet Rheumatology (2021)
Treatment Outcomes and Prognostic Factors in 40 Patients with Primary Effusion Lymphoma
Authors: Krithika Shanmugasundaram, Ramya Ramaswami, Anaida Widell, Ralph Mangusan, Elaine S. Jaffe, Stefania Pittaluga, Hao-Wei Wang, Vickie Ann Marshall, Denise Whitby, Richard F. Little, Mark N. Polizzotto, Thomas S. Uldrick, Robert Yarchoan, Kathryn A. Lurain
Journal: Blood (2021)
Abstract 11882: The Relationship Between Day-to-Day Variability in Home Blood Pressure and Multiple Organ Function
Authors: Takuro Kubozono, Yuichi Akasaki, Shin Kawasoe, Satoko Ojima, Takeko Kawabata, So Kuwahata, Toshihiro Takenaka, Yoshiyuki Ikeda, Mitsuru Ohishi
Journal: Circulation (2021)

Introduction: Blood pressure variability (BPV) is associated with the prognosis of cardiovascular disease. Continuous home BP measurements can be used to assess day-to-day BPV. Day-to-day BPV is associated with poor cognitive function, and the onset and progression of dementia. However, it is not clear how BPV is related to various organs. Hypothesis: Day-to-day BPV is related to various organ functions. Methods: Three hundred sixty-six participants (136 male, mean age: 71±9 years) who were participated in the community-based health checkup survey in Tarumizu city. All participants measured home blood pressure using HEM-9700T (OMRON Healthcare, Kyoto, Japan). Day-to-day variability of systolic blood pressure were evaluated by coefficient of variation (CV) of home systolic blood pressure in morning during one month. CV was categorized into quartiles. NT-pro BNP and high-sensitivity (hs-)troponin T as cardiac biomarkers were measured. Liver stiffness and renal function were evaluated by Fibrous-4 (Fib4) index and estimated glomerular filtration rate (eGFR), respectively. NT-pro BNP and hs-troponin T were divided by median value. Fib4 index greater than 2.67 and eGFR less than 60 mL/min/1.73 m2 were defined as high Fib4 index and high eGFR. Results: Mean CV was 6.0±1.7%. In logistic analysis adjusted age, gender and receiving antihypertensive medication, the odds ratios for high eGFR and high Fib4 index were higher in the higher quartiles, and only the fourth quartile was an independently associated factor. Moreover, for high NT-pro BNP levels, it was an independent factor in all three quartiles of CV. In contrast, for high troponin T levels, no associations were found for all quartiles of CV (Figure). Conclusion: Day-to-day BPV is independently associated with NT-pro BNP, eGFR and Fib4 index, but not with hs-troponin T.
Abstract 10001: The Systemic Inflammation-Based Glasgow Prognostic Score Predicts Prognosis in Acute Decompensated Heart Failure Patients with Preserved Left Ventricular Ejection Fraction: A Multicenter Study
Authors: Shohei Yoshima, Yoshiyuki Nagai, Ryu Shutta, Daisuke Masuda, Shunsuke Tamaki, Ryosuke Muraki, Makoto Abe, Koji Sako, Shizuya Yamashita, Masahiro Seo, Takahisa Yamada, Akito Nakagawa, Yoshio Yasumura, Yusuke Nakagawa, Masamichi Yano, Takaharu Hayashi, Shungo Hikoso, Yohei Sotomi, Yasushi Sakata
Journal: Circulation (2021)

Background: A systemic inflammatory state caused by comorbidities has been shown to play a key role in pathophysiology of heart failure with preserved ejection fraction (HFpEF). The inflammation-based prognostic score termed Glasgow prognostic score (GPS), combining C-reactive protein and albumin, has been reported to provide prognostic information in patients with cancer or heart failure. However, little is known about the usefulness of the GPS for the prediction of prognosis in patients with HFpEF who are admitted with acute decompensated heart failure (ADHF). Methods: Patients' data were extracted from The Prospective mUlticenteR obServational stUdy of patIenTs with Heart Failure with Preserved Ejection Fraction (PURSUIT-HFpEF) study, which is a prospective multicenter observational registry for ADHF patients with LVEF ≥50% in Osaka area. We studied 1017 patients who survived to discharge. The GSP was calculated at discharge as follows: patients with both elevated C-reactive protein (&gt;1.0mg/dL) and hypoalbuminemia (&lt;3.5g/dL) were allocated a score of 2, patients with one of these abnormalities were allocated a score of 1, and patients with neither of these were allocated a score of 0. The endpoint was all-cause death. Results: During a follow-up period of 1.5±1.2 years, 178 patients had all-cause death. At multivariate Cox analysis, GPS 1 (hazard ratio [HR] 1.71, 95% confidence interval [CI] 1.14-2.56, p=0.0090) and GPS 2 (HR 2.42, 95% CI 1.51-3.88, p=0.0003) were independently associated with all-cause death after the adjustment for major confounders. There was significant difference in the rate of all-cause death when the patients were stratified according to the GPS (Figure). Conclusions: In this multicenter study, the systemic inflammation-based GPS was shown to be useful for the prediction of prognosis in HFpEF patients admitted for ADHF.
Abstract 11054: A Novel Method of Conjunctival Vascular Screening to Detect Hemodynamic Alterations in Patients with Coronary Microvascular Disease
Authors: Jonathan A Mailey, Julie S Moore, Paul F Brennan, Min Jing, Agnes Awuah, James A McLaughlin, Andrew A Nesbit, Andrew T Nesbit, Mark S Spence
Journal: Circulation (2021)

Introduction: A large proportion of patients with cardiovascular disease (CVD) remain asymptomatic until presentation with myocardial infarction. Conventional CV risk assessment can be augmented by investigations such as CT coronary artery calcium scoring; but are limited by cost, availability and exposure to ionizing radiation. This study utilizes the conjunctiva as a network of blood vessels that can be assessed non-invasively in order to compare hemodynamic parameters in patients with and without established coronary microvascular disease (MVD). Methods: We assessed the conjunctival microcirculation of patients diagnosed with angina undergoing invasive coronary angiography and physiological evaluation of epicardial stenoses and MVD. All patients had haemodynamically insignificant epicardial disease (FFR ≥0.80). Conjunctival imaging was performed using an adapted iPhone 11pro and slit-lamp biomicroscope. We compared a cohort of patients with MVD (IMR ≥25); to a group of controls without MVD (IMR &lt;25). Results: A total of 54 patients were included (19 MVD and 35 controls). Table 1 demonstrates a comparison of baseline demographics and hemodynamics between the groups. A total of 866 conjunctival vessels were analysed (366 MVD and 500 controls) and the differences in microvascular parameters between groups determined ( Table 2) . Statistically significant differences were observed in axial velocity, cross sectional velocity and blood flow rate. Conclusion: This study demonstrates the ability to non-invasively detect abnormal microvascular function. The conjunctival microcirculation therefore has potential merit to complement conventional CV risk screening.
Abstract 11349: Substance Use and Associated Risk of Incident Atrial Fibrillation
Authors: Anthony Lin, gregory nah, Eric Vittinghoff, Gregory M Marcus
Journal: Circulation (2021)

Introduction: Atrial fibrillation (AF) is a common arrythmia associated with high morbidity and mortality. Understanding modifiable risk factors that contribute to AF could have a broad impact on patient outcomes. While work has been done to understand the association between alcohol use and AF, there is limited understanding in the relationship between non-alcohol substance use and new-onset AF. Our study sought to investigate the associations of methamphetamine, cocaine, opiate, and cannabis use with incident AF. Methods: This is a retrospective observational study of 23,561,844 adult inpatient hospitalizations and ED visits from January 1, 2005 to September 30, 2015 in California’s Office of Statewide Health Planning and Development (OSHPD) database. International Classification of Disease (ICD) codes were used to document AF and methamphetamine, cocaine, opiate, or cannabis use disorders. All patients with prevalent AF were excluded from analysis. Results: Methamphetamine use (n=98,271), cocaine use (n=48,700), opiate use (n=10,032), and cannabis use (n=132,834) disorders were coded as part of routine clinical care. In multivariate analysis adjusting for age, race, sex, income, and cardiovascular risk factors, methamphetamine, cocaine, opiate, and cannabis use were associated with higher incidence of AF ( Table ). The cumulative probability of incident AF increased over time with all four substances ( Figure ). Conclusion: Patients with documented methamphetamine, cocaine, opiate, or cannabis use disorders had an increased risk of incident AF that was independent of the risk already portended by established cardiovascular risk factors.