tbuckley/cabot-search huggingface dataset:
Late results in patients with tetralogy of Fallot repaired during infancy.
Authors: E PWalsh, SRockenmacher, J FKeane, T JHougen, J ELock, A RCastaneda
Journal: Circulation (1988)

Between 1973 and 1985, 220 infants (age 1 day to 18 months, mean = 7 months) underwent repair of tetralogy of Fallot (TOF) or TOF/pulmonary atresia with 17 early deaths. Follow-up status was ascertained for 184 of 203 survivors (91%) at a postoperative interval of 2 to 185 months (mean = 60 months). Significant residual hemodynamic lesions included ventricular septal defect in three, and right ventricular outflow gradient in excess of 40 mm Hg in 24. Reoperation or interventional catheter procedures were performed in 31 of 184 (17%) patients. All postoperative electrocardiograms were reviewed; only two of 184 patients had ventricular ectopy on any tracing. Holter data from 41 patients revealed one with sinus node dysfunction, 12 with Lown grade 1 ectopy, and one with Lown grade 2 or greater. Conduction defects, evaluated by electrocardiographic and electrophysiologic measurements, were not different from those reported for TOF patients undergoing repair at later ages. No study patient received antiarrhyth...
Oxygen radicals mediate the cerebral arteriolar dilation from arachidonate and bradykinin in cats.
Authors: H AKontos, E PWei, J TPovlishock, C WChristman
Journal: Circulation Research (1984)

Topical application of sodium arachidonate (50-200 micrograms/ml) or bradykinin (0.1-10 micrograms/ml) on the brain surface of anesthetized cats caused dose-dependent cerebral arteriolar dilation. This dilation was blocked by 67-100% in the presence of superoxide dismutase and catalase. These enzymes did not affect the changes in arteriolar diameter caused by alterations in arterial blood PCO2, or the arteriolar dilation from topical acetylcholine. Enzymes inactivated by heat had no effect on the vasodilation from arachidonate or bradykinin. Superoxide dismutase alone or catalase alone reduced the dilation during application of 200 micrograms/ml of arachidonate for 15 minutes; they also completely prevented the residual dilation seen 1 hour after washout, as well as the reduction in the vasoconstrictive effects of arterial hypocapnia observed at this time. The results show that superoxide anion radical and hydrogen peroxide, or radicals derived from them, such as the hydroxyl radical, are mediators of the...
Carotid sinus reflex in patients undergoing coronary angiography: relationship of degree and location of coronary artery disease to response to carotid sinus massage.
Authors: K ABrown, J DMaloney, C HSmith, G OHaritzler, D MIlstrup
Journal: Circulation (1980)

Heart rate and blood pressure responses during and after carotid sinus massage were examined in 66 patients just before coronary angiography. A significant relationship was found between heart rate and blood pressure responses and (1) angina pectoris class, (2) total coronary artery disease score and (3) presence of high-grade (> 90%) stenosis of any of the three major coronary arteries. Only patients with contraction abnormalities of the anterolateral left ventricular region had greater cardionhibitory responses than patients with normal left ventricular angiograms. Among patients with normal left ventricular angiograms, those with more than 50% stenosis of one or more vessels had significantly (p < 0.01) greater responses than those with no or minimal coronary artery disease. All 21 hypersensitive (asystole longer than 3 seconds) patients had significant multivessel coronary artery stenoses or single-vessel high-grade stenosis (greater than or equal to 90%) proximal to the atrioventricular nodal artery....
Long-acting cabotegravir plus rilpivirine for treatment in adults with HIV-1 infection: 96-week results of the randomised, open-label, phase 3 FLAIR study
Authors: Chloe Orkin, Shinichi Oka, Patrick Philibert, Cynthia Brinson, Ayesha Bassa, Denis Gusev, Olaf Degen, Juan González García, Enrique Bernal Morell, Darrell H S Tan, Ronald D'Amico, David Dorey, Sandy Griffith, Shanker Thiagarajah, Marty St Clair, Rodica Van Solingen-Ristea, Herta Crauwels, Susan L Ford, Parul Patel, Vasiliki Chounta, Simon Vanveggel, Amy Cutrell, Veerle Van Eygen, Kati Vandermeulen, David A Margolis, Kimberly Y Smith, William R Spreen
Journal: The Lancet HIV (2021)
Dietary intake of vitamin A, lung function and incident asthma in childhood
Authors: Mohammad Talaei, David A. Hughes, Osama Mahmoud, Pauline M. Emmett, Raquel Granell, Stefano Guerra, Seif O. Shaheen
Journal: European Respiratory Journal (2021)

Longitudinal epidemiological data are scarce on the relationship between dietary intake of vitamin A and respiratory outcomes in childhood. We investigated whether a higher intake of preformed vitamin A or pro-vitamin β-carotene in mid-childhood is associated with higher lung function and with asthma risk in adolescence.
The sequence of normal recovery of excitability in the dog heart.
Authors: J AAbildskov
Journal: Circulation (1975)

The sequence with which 18 to 70 ventricular sites recovered excitability after normal excitation was determined in 15 dogs. At the epicardial level the recovery sequence was similar to that of normal activation. The sequence of excitation and recovery differed at the endocardium with some basal areas recovering excitability earlier than the apex despite later activation. Evidence of a normal epicardial to endocardial recovery sequence was also obtained. The findings are compatible with and provide a tentative explanation of some features of T waves in human body surface electrocardiograms.
Efficacy Of EUS-Guided Biliary Drainage For Malignant Hilar Obstruction And Failed/Partial Drainage by ERCP
Authors: V Dhir, R Shah, P Udawat
Journal: Endoscopy (2021)

Aims To assess the safety and efficacy of EUS-BD for malignant hilar obstruction in short and medium term,in patients with failed/partial drainage by ERCP.
Microwave catheter ablation of myocardium in vitro. Assessment of the characteristics of tissue heating and injury.
Authors: J GWhayne, SNath, D EHaines
Journal: Circulation (1994)

BACKGROUNDRadiofrequency (RF) catheter ablation lesion size has been limited by the small volume of tissue directly heated by the RF electrode. Microwave (MW) energy has been proposed as an alternative energy source to generate larger lesions because of its increased volume of direct tissue heating. To further characterize MW ablation of myocardium, we studied the temperature-versus-distance profiles during MW ablation in an in vitro model of perfused and superfused porcine right ventricular free wall.METHODS AND RESULTSRadial tissue temperatures in 19 isolated porcine right ventricles were measured and recorded with four fluoroptic thermometry probes placed within the myocardium at 2.5-mm radial increments from the catheter. The MW antenna catheters used were monopolar and helical-coil antennas resonating at 915 and 2450 MHz. Durations of energy delivery for a 915-MHz MW monopolar antenna (60 to 600 seconds) and a 4-mm-tip RF electrode (60 and 300 seconds) were varied to compare time courses of lesion fo...
Quantitative adenosine 201Tl single-photon emission computed tomography for the early assessment of patients surviving acute myocardial infarction.
Authors: J JMahmarian, C MPratt, SNishimura, AAbreu, M SVerani
Journal: Circulation (1993)

BACKGROUNDWe prospectively investigated whether adenosine 201Tl tomography (SPECT) could determine the extent of coronary artery disease, the presence of jeopardized myocardium, and the risk for in-hospital cardiac events in 120 clinically stable patients early (5 +/- 3 days) after myocardial infarction.METHODS AND RESULTSAll patients had coronary angiography and SPECT in close proximity. Adenosine SPECT identified 99% of infarct-related arteries and 82% of severely stenosed (> or = 70%) noninfarct arteries. Multivessel disease was accurately predicted in 69% of patients. Sixty-five percent of stenosed noninfarct arteries had matching thallium perfusion defects, and 92% of these were reversible. The specificity of adenosine SPECT was > 90%. Thallium redistribution occurred often within infarct (59%) and noninfarct (92%) zones. The patency status of the arteries, however, did not predict the presence or extent of jeopardized myocardium. The perfusion defect size was larger (p = 0.0001) in patients with (45...
Efficacy Of Theconcomitant Quadruple Therapy for The Eradication Of Helicobacter Pylori
Authors: R Harbi, S Mrabet, S Zaouga, I Akkari, E Ben Jazia
Journal: Endoscopy (2021)

Aims Helicobacter pylori (H. pylori) infection is widespread throughout the world, with a prevalence ranging from 30 to 80 %. The bacteria is resistant to gastric acidity due to its bacteriological characteristics. It is implicated in the occurrence of many potentially serious peptic diseases. Its eradication is a real therapeutic challenge.
RE : External Validity of a Trial Comprised of Elderly Patients With Hormone Receptor-Positive Breast Cancer Response
Authors: W. van de Water, M. Kiderlen, E. Bastiannet, R.G.J. Westendorp, C.J.H. van de Velde, A.J.M. de Craen, G.J. Liefers
Journal: JNCI Journal of the National Cancer Institute (2014)
Modulation of ischemia/reperfusion-induced microvascular dysfunction by nitric oxide.
Authors: IKurose, RWolf, M BGrisham, D NGranger
Journal: Circulation Research (1994)

Leukocyte-endothelial cell adhesion and an altered metabolism of endothelial cell-derived nitric oxide (NO) have been implicated in the microvascular dysfunction associated with ischemia/reperfusion (I/R). The objective of this study was to determine whether NO donors can attenuate the reperfusion-induced increase in venular albumin leakage via an effect on leukocyte-endothelial cell adhesion. Leukocyte adherence and emigration as well as albumin extravasation were monitored in single postcapillary venules in rat mesentery subjected to 20 minutes of ischemia followed by 30 minutes of reperfusion. This I/R protocol elicits significant leukocyte adherence and emigration as well as a profound albumin leakage response. Superfusion of the mesenteric microcirculation with the NO donors sodium nitroprusside, spermine-NO, and SIN1 significantly reduced the I/R-induced leukocyte adherence/emigration and albumin leakage in postcapillary venules, whereas neither spermine nor the NO synthase inhibitor NG-nitro-L-argi...
Conjoined Consent: Informed Consent When Donor and Recipient Are Both Research Participants
Authors: Liza-Marie Johnson, Devan M. Duenas, Benjamin S. Wilfond
Journal: The American Journal of Bioethics (2021)

"Conjoined Consent: Informed Consent When Donor and Recipient Are Both Research Participants." The American Journal of Bioethics, 21(4), pp. 106–107
A Rare and Unusual Rectal Tumor
Authors: A Ebigbo, C Fleischmann, H Messmann
Journal: Endoscopy (2021)

An asymptomatic 51-year old man presented for screening colonoscopy. An unusual rectal lesion was seen at about 5 cm from the anal verge. It had an elongated shape with a pocket-like centre and heaped-up borders. The mucosa inside the pocket had round pits as well as a villous architecture. Forceps biopsy revealed gastric mucosa, and rectal gastric heterotopia was suspected. Because of its potential to develop malignancy, an endoscopic en-bloc resection was performed. Surprisingly, histopathology showed both gastric and pancreatic tissue, making this case an extremely rare and unusual report of a mixed gastric and pancreatic heterotopia in the rectum.
Kinetics of interaction of the lidocaine metabolite glycylxylidide with the cardiac sodium channel. Additive blockade with lidocaine.
Authors: D JWendt, C FStarmer, A OGrant
Journal: Circulation Research (1992)

The recovery of the sodium channel from blockade by local anesthetic antiarrhythmic drugs is voltage dependent. Recovery from lidocaine-induced blockade is accelerated by hyperpolarization, whereas that from glycylxylidide (GX) blockade has been reported to be slowed by hyperpolarization. This striking difference occurs despite similarities in chemical structure. The fast recovery from GX block at depolarized potentials may lead to a partial reversal of lidocaine blockade when the two drugs are combined. We have examined the kinetics of interaction of GX with the cardiac sodium channel over a range of membrane potentials by measuring whole-cell currents in isolated rabbit myocytes under voltage clamp at 15 degrees C. In the absence of drug, slow inactivation developed with a time constant of 10.7 +/- 5.1 seconds (n = 6). During exposure to 74 mumol/l GX, block developed with a time constant of 7.0 +/- 3 seconds (n = 6). Because of the similar time course of slow inactivation and block, we used a high conc...
Calcium and magnesium transport by in situ mitochondria: electron probe analysis of vascular smooth muscle.
Authors: RBroderick, A PSomlyo
Journal: Circulation Research (1987)

The extent, time course, and reversibility of mitochondrial Ca2+ uptake secondary to cellular Ca2+ influx stimulated by massive Na+ efflux were evaluated by electron probe microanalysis of rabbit portal vein smooth muscle. Strips of portal vein were Na+ loaded for 3 hours at 37 degrees C in a K+-free 1 mM ouabain solution, after which rapid Na+ efflux was induced by washing with a Na+-free K+-Li+ solution (1 mM ouabain). Li+ washing Na+-loaded portal vein produced a large transient contraction accompanied by an increase (over 100-fold) in mitochondrial Ca2+ and also significant (p less than 0.05) increases in phosphorus and Mg2+. The Ca2+ loading of the mitochondria was reversed during prolonged Li+ wash, and by 2 hours, mitochondrial Ca2+, Mg2+, and phosphorus had returned to control levels. The maximal contractile response to stimulation remained normal, demonstrating that pathologic Ca2+ loading of mitochondria is reversible in situ and compatible with normal maximal force developed by the smooth muscl...
Hemodynamic effects of nitroprusside in infants with a large ventricular septal defect.
Authors: R HBeekman, A PRocchini, ARosenthal
Journal: Circulation (1981)

To evaluate the effect of acute vasodilator therapy, nitroprusside was administered at cardiac catheterization to five infants (ages 10 days to 6 months) with isolated ventricular septal defect and congestive heart failure. Intravenous nitroprusside was begun at a dose of 0.5 micrograms/kg/min and was increased by increments of 0.5 micrograms/kg. Hemodynamic measurements were made before nitroprusside, after 5 minutes at each dose, and 10 minutes after nitroprusside was discontinued. Baseline data were obtained before nitroprusside administration and compared with data obtained at maximal nitroprusside dose. The pulmonary-to-systemic flow ratio increased from 2.2 +/- 0.2 to 3.4 +/- 0.2 (mean +/- SEM, p less than 0.05) as a consequence of a marked decrease in systemic blood flow (5.3 +/- 0.7 to 3.6 +/- 0.51/min/m(2), p less than 0.05). Pulmonary flow did not change significantly. Mean pulmonary capillary wedge and right atrial pressures decreased by 53% (10.2 +/- 1.4 to 4.8 +/- 1.4 mm Hg [p less than 0.01]...
Plasmodium knowlesi infection imported to Germany, January 2013
Authors: H Orth, B O Jensen, M C Holtfreter, S J Kocheril, S Mallach, C MacKenzie, I Müller-Stöver, B Henrich, M Imwong, N J White, D Häussinger, J Richter
Journal: Eurosurveillance (2013)

Plasmodium knowlesi was known as a plasmodium of macaques until P. knowlesi transmission to humans was recognised in Borneo and later throughout South-East Asia. We describe here a case of a P. knowlesi infection imported to Germany from Thailand. The patient had not taken antimalarial chemoprophylaxis and suffered from daily fever attacks. Microscopy revealed trophozoites and gametocytes resembling P. malariae. P. knowlesi malaria was confirmed by PCR.
Peripheral vascular disease. Rheologic variables during controlled ischemia.
Authors: GCiuffetti, MMercuri, EMannarino, M KRobinson, S ELennie, GLowe
Journal: Circulation (1989)

The quantitative and qualitative behavior of hemorheologic factors both at rest and after treadmill exercise in 30 male patients with stage II peripheral vascular disease compared with 20 sex- and age-matched healthy controls have been studied. The aim of our study was to identify functional rheologic markers for peripheral vascular disease. At rest, whole blood viscosity (corrected for hematocrit at both high and low shear rates), fibrinogen levels (4.23 +/- 1.39 vs. 3.23 +/- 1.5), and white blood cell count (7.05 +/- 1.25 vs. 6.03 +/- 1.28) were significantly different between patients and controls. After treadmill exercise, white blood cell counts increased in both patients and controls, whereas only the filterability of mononuclear leukocytes showed a significant variation in the patient group (5.47 +/- 1.54 vs. 7.26 +/- 2.00, p less than 0.002). In this group, mononuclear filterability improved during the recovery period. The results suggest a relation between exercise-induced ischemia of the lower l...
Blood pressure and vascular resistance in genetically hypertensive rats treated at birth with 6-hydroxydopamine.
Authors: D WClark, D RJones, E LPhelan, C EDevine
Journal: Circulation Research (1978)

Genetically hypertensive (GH) rats of the New Zealand strain and normotensive (N) rats were sympathectomized from birth with 6-hydroxydopamine (100 mg/kg,s.c, on alternate days, seven treatments). In adult treated rats from each strain (GHTr and NTr), blood pressure was lower than normal. Functional tests and electron microscopy showed that denervation was virtually complete in mesenteric and hindlimb arteries; the innervation of the renal artery was little affected. Ganglionic blockade still caused a large fall in blood pressure in treated rats. Vascular resistance was higher in blood-perfused hindlimbs and tails of GH rats than in those of N rats; in contrast, resistance was similar in limbs and tails of GHTr and NTr rats and was greater than that found in untreated N rats. Saline-perfused limb vessels had neither neurogenic nor myogenic tone and resistance was higher in GH limbs (whether these were from treated rats or not) than in untreated N limbs. In saline-perfused NTr limbs, there was a paradoxica...
Scaling Up Covid-19 Vaccination in Africa — Lessons from the HIV Pandemic
Authors: Jean B Nachega, Nadia A Sam-Agudu, John W Mellors, Alimuddin Zumla, Lynne M Mofenson
Journal: New England Journal of Medicine (2021)

Scaling Up Covid-19 Vaccination in Africa In the mid-1990s and early 2000s, highly active antiretroviral treatment was accessible in high-income countries but had limited availability in African co...
Digital subtraction angiographic imaging of coronary flow reserve.
Authors: J TCusma, E JToggart, J DFolts, W WPeppler, N JHangiandreou, C SLee, C AMistretta
Journal: Circulation (1987)

Recent studies have demonstrated that subjective assessment of the severity of coronary artery stenoses results in poor interobserver concordance and poor correlation with physiologic significance as determined by Doppler measurements of coronary flow reserve. Use of the coronary flow reserve as an integrated measure of the effect of stenosis geometry has been emphasized within the context of quantitative cinemetric analysis. The comparison of two parametric digital subtraction angiographic flow images obtained before and after hyperemic intervention has led to calculation of flow reserve values that correlate well with electromagnetic flowmeter data in dogs. By means of a similar model relating blood flow and image variables, single flow ratio images have been formed. These parametric images provide a two-dimensional display of the ratio of hyperemic flow to baseline flow. Linear temporal interpolation of data from a sequence of cardiac phase-matched subtraction images is used to improve the resolution o...
Improved left ventricular diastolic filling in patients with coronary artery disease after percutaneous transluminal coronary angioplasty.
Authors: R OBonow, K MKent, D RRosing, L CLipson, S LBacharach, M VGreen, S EEpstein
Journal: Circulation (1982)

Left ventricular (LV) diastolic filling is abnormal at rest in many patients with coronary artery disease (CAD), even in the presence of normal resting LV systolic function. To determine the effects of improved myocardial perfusion on impaired. LV diastolic filling, we studied 25 patients with one-vessel CAD by high-temporal-resolution radionuclide angiography before and after percutaneous transluminal coronary angioplasty (PTCA). No patient had ECG evidence of previous myocardial infarction. Despite normal regional and global LV systolic function at rest in all patents, LV diastolic filling was abnormal (peak LV filling rate [PFR] less than 2.5 end-diastolic volumes (EDV)/sec or time to PFR greater than 180 msec) in 17 of 25 patients. Twenty-three patients had abnormal LV systolic function during exercise. After successful PTCA, LV ejection fraction and heart rate at rest were unchanged, but LV ejection fraction during exercise increased, from 52 +/- 8% (+/- SD) to 63 +/- 5% (p less than 0.001). LV diast...
Who Should Undergo Transplant for Metastatic Colorectal Cancer?
Authors: Yuman Fong
Journal: JAMA Surgery (2021)

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Nonobstructive left ventricular ejection pressure gradients in man.
Authors: APasipoularides, J PMurgo, J WMiller, W ECraig
Journal: Circulation Research (1987)

Simultaneous intraventricular pressure gradients and ejection flow patterns were measured by a multisensor catheter in 6 patients with normal left ventricular function and no valve abnormalities, at rest and in exercise. Peak measured intraventricular pressure gradients were attained very early in ejection, amounted to 6.7 +/- 1.9 (SD) mm Hg at rest, and were intensified to 13.0 +/- 2.3 mm Hg during submaximal supine bicycle exercise. The augmentation of the gradients during exercise was associated with a pronounced accentuation of the flow acceleration and flow at the instant of peak gradient. A peak flow, the intraventricular gradients amounted to 5.4 +/- 1.7 mm Hg at rest and 10.0 +/- 1.8 mm Hg during submaximal exercise. The exercise-induced enhancement of the measured intraventricular pressure difference at the time of peak flow was underlain by an accentuation of the peak flow itself. A semiempirical fluid dynamic model for ejection was applied to the pressure gradient and simultaneous outflow rate ...