Effects of Low-Carbohydrate and Low-Fat Diets
Authors: Lydia A. Bazzano, Tian Hu
Journal: Annals of Internal Medicine (2015)

Letters3 March 2015Effects of Low-Carbohydrate and Low-Fat DietsLydia A. Bazzano, MD, PhD, MPH and Tian Hu, MD, MSLydia A. Bazzano, MD, PhD, MPHFrom Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.Search for more papers by this author and Tian Hu, MD, MSFrom Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-5057-5 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree wholeheartedly with Drs. Burns and Miyashita that physical activity is a vital component of weight management and cardiovascular health. In our clinical trial, physical activity levels did not significantly differ between the groups at baseline or during the intervention. Although it was not the aim of our study, future studies should examine whether physical activity levels modify the differences in efficacy of low-fat and low-carbohydrate diets.Drs. Donzelli and Lafranconi raise several concerns about low-carbohydrate diets. They note that a meta-analysis showed that low-carbohydrate and low-fat diets were similarly effective for weight loss at 12-month follow-up ...References1. Johnston BC, Kanters S, Bandayrel K, Wu P, Naji F, Siemieniuk RA, et al. Comparison of weight loss among named diet programs in overweight and obese adults: a meta-analysis. JAMA. 2014;312:923-33. [PMID: 25182101] doi:10.1001/jama.2014.10397 CrossrefMedlineGoogle Scholar2. Schwarzfuchs D, Golan R, Shai I. Four-year follow-up after two-year dietary interventions [Letter]. N Engl J Med. 2012;367:1373-4. [PMID: 23034044] doi:10.1056/NEJMc1204792 CrossrefMedlineGoogle Scholar3. Hu T, Mills KT, Yao L, Demanelis K, Eloustaz M, Yancy WS, et al. Effects of low-carbohydrate diets versus low-fat diets on metabolic risk factors: a meta-analysis of randomized controlled clinical trials. Am J Epidemiol. 2012;176 Suppl 7:S44-54. [PMID: 23035144] doi:10.1093/aje/kws264 CrossrefMedlineGoogle Scholar4. Fung TT, van Dam RM, Hankinson SE, Stampfer M, Willett WC, Hu FB. Low-carbohydrate diets and all-cause and cause-specific mortality: two cohort studies. Ann Intern Med. 2010;153:289-98. [PMID: 20820038]. doi:10.7326/0003-4819-153-5-201009070-00003 LinkGoogle Scholar5. Nilsson LM, Winkvist A, Eliasson M, Jansson JH, Hallmans G, Johansson I, et al. Low-carbohydrate, high-protein score and mortality in a northern Swedish population-based cohort. Eur J Clin Nutr. 2012;66:694-700. [PMID: 22333874] doi:10.1038/ejcn.2012.9 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M14-0180. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffects of Low-Carbohydrate and Low-Fat Diets Lydia A. Bazzano , Tian Hu , Kristi Reynolds , Lu Yao , Calynn Bunol , Yanxi Liu , Chung-Shiuan Chen , Michael J. Klag , Paul K. Whelton , and Jiang He Effects of Low-Carbohydrate and Low-Fat Diets Stephen F. Burns and Masashi Miyashita Effects of Low-Carbohydrate and Low-Fat Diets Alberto Donzelli and Alessandra Lafranconi Effects of Low-Carbohydrate and Low-Fat Diets Gaetano Santulli Effects of Low-Carbohydrate and Low-Fat Diets Murray Skeaff , Jim Mann , Lisa Te Morenga , and Rachael McLean Effects of Low-Carbohydrate and Low-Fat Diets Alberto Donzelli and Alessandra Lafranconi Effects of Low-Carbohydrate and Low-Fat Diets Stephen F. Burns and Masashi Miyashita Effects of Low-Carbohydrate and Low-Fat Diets Murray Skeaff , Jim Mann , Lisa Te Morenga , and Rachael McLean Effects of Low-Carbohydrate and Low-Fat Diets Gaetano Santulli Metrics Cited byThe ketogenic diet in health and diseaseEffect of a Low-Carbohydrate High-Fat Diet and a Single Bout of Exercise on Glucose Tolerance, Lipid Profile and Endothelial Function in Normal Weight Young Healthy Females 3 March 2015Volume 162, Issue 5Page: 393KeywordsBody mass indexClinical trialsDietDisclosureExerciseFatsMortalityObservational studiesProteinsWeight loss ePublished: 3 March 2015 Issue Published: 3 March 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...