tbuckley/cabot-search huggingface dataset:
The use of echocardiography in diagnosing culture-negative endocarditis.
Authors: D SRubenson, C RTucker, E BStinson, E JLondon, POyer, RMoreno-Cabral, R LPopp
Journal: Circulation (1981)

We reviewed M-mode and two-dimensional echocardiographic findings in 11 patients with abacteremic endocarditis to study the application of echocardiography in this setting. All patients had negative blood cultures but underwent surgery that confirmed the presence of active infective endocarditis. The infection involved native valves in five patients and prosthetic valves in six patients. Valvular masses were identified in eight patients. The other three patients, who had prosthetic aortic valves, had diastolic mitral valve vibration characteristic of aortic regurgitation. One of these also showed dehiscence of the prosthesis. Three patients had poorly defined clinical illnesses and echocardiography was a prime element in the diagnosis because valvular masses were identified. The operation was facilitated by knowledge of the mass indicated by echocardiography in these eight cases. Also, the surgical approach was affected by knowledge of dehiscence and perivalvular abscess formation in two cases each.
Relief of ocular symptoms in patients with house dust mite allergic rhinitis treated with the 300IR house dust mite SLIT tablet
Authors: C. Vidal, T. Casale, P. Creticos, F. De Blay, Philippe Gevaert, E. Karagiannis, L. Klimek, K. Kowal, M. Le Gall, N. Nenasheva, G. Passalacqua, O. Pfaar, M. Tortajada-Girbes, M. Worm, P. Demoly
Journal: Allergy (2020)
Adenovirus-mediated transfer of a gene encoding human apolipoprotein A-I into normal mice increases circulating high-density lipoprotein cholesterol.
Authors: W PKopfler, MWillard, TBetz, J EWillard, R DGerard, R SMeidell
Journal: Circulation (1994)

BACKGROUNDIn animal models of atherosclerosis, augmentation of circulating high-density lipoprotein (HDL) cholesterol exerts a protective effect against development of fatty streaks and promotes plaque regression.METHODS AND RESULTSTo investigate the potential of gene transfer to increase HDL cholesterol, a fusion gene encoding human apolipoprotein A-I (apo A-I) under the control of the human cytomegalovirus (CMV) immediate-early promoter was packaged into a recombinant adenovirus (AdCMV apo A-I). BALB/c mice infected with AdCMV apo A-I by intravenous injection accumulate immunoreactive apo A-I in serum; levels 5 days after infection averaged 168 mg/dL. A 35% increase in HDL cholesterol and a 47% increase in total cholesterol were observed in mice infected with AdCMV apo A-I compared with control viruses. Analysis of size-fractionated lipoproteins revealed that human apo A-I is incorporated into murine HDL particles. Expression of human apo A-I declined to < 10% of maximum after 12 days and mRNA encoding ...
Rendezvous Ercp Via EUS-Guided Gallbladder Drainage To Salvage Lumen-Apposing Metal Stent (LAMS) Dislodgement During EUS-Guided Choledochoduodenostomy
Authors: R Sanchez-Ocaña, M de Benito Sanz, R Najera Muñoz, C Chavarria Herbozo, C de la Serna Higuera, M Perez-Miranda
Journal: Endoscopy (2021)

Biliary (distal) flange dislodgment occurred during EUS-choledochoduodenostomy with LAMS for unresectable pancreatic malignancy. Guidewire dislodgment precluded a bridging stent. Aerobilia hampered repeat EUS-guided puncture. The gallbladder was used as a surrogate target for biliary drainage. A 15-mm cholecystogastric LAMS was placed under EUS-guidance. To minimize choledochal leakage, rendezvous ERCP was also undertaken. Through-the-LAMS cholecystoscopy with a gastroscope allowed antegrade transcystic guidewire passage into the duodenum. Parallel cannulation with a slit sphincterotome allowed fully-covered biliary metal stent placement across the stricture, overlapping the choledochal perforation. The dislodged biliary LAMS was removed, closing with hemoclips the duodenal perforation. The patient recovered uneventfully.
Shall The Journal be Removed to Washington?
Authors: E. T. Tidd
Journal: JAMA (1891)

<h3>To the Editor:</h3> —Having looked the ground all over fairly and carefully I have come to the conclusion that there is no place better fitted for its publication than Chicago. There are many reasons why, but as they are familiar to all I will not rehearse any. Clark, Pa., March 12, 1891.
Peptic Ulcer Disease in Patients Under Antiplatelets or Anticoagulants: Analysis of Upper Gastrointestinal Endoscopy Findings
Authors: I Mitselos, M Moutzoukis, C Lamouri, N Tsoumani, A Petrou, F Fousekis, G Baxevanos, G Dimos, L Raptis, T Tzimas, E Arvaniti, N Gkizas, I Liapis, D Christodoulou
Journal: Endoscopy (2021)

Aims Among others, peptic ulcer disease is associated with certain drug classes. Our aim was to analyze the risk of peptic ulcer disease (PUD) in patients with hematemesis/melena/hematochezia, receiving anticoagulant or antiplatelet therapy.
Myocardial metabolites of ethanol.
Authors: L GLange, B ESobel
Journal: Circulation Research (1983)

Because of the importance of alcohol-induced heart muscle disease and the obscurity of its pathogenesis, this study was undertaken to determine whether fatty acid ethyl esters, myocardial metabolites of ethanol recently described in our laboratory to be synthesized in cell-free extracts of rabbit myocardium, accumulate in hearts of human subjects exposed to ethanol in vivo. Lipid extracts were prepared from left ventricular samples obtained at necropsy from six subjects who had been exposed to ethanol acutely or chronically. Fatty acid ethyl esters were present in each extract in concentrations ranging from 9 to 115 microM. In contrast, they were consistently absent from analogous samples obtained from hearts of abstainers (n = 5). In parallel studies in experimental animals, we found that fatty acid ethyl esters are formed not only in the heart but also in the pancreas and liver--targets of injury associated with chronic alcohol abuse. These results demonstrate the presence in human myocardium of a novel...
Delayed afterdepolarizations and triggered activity induced in feline Purkinje fibers by alpha-adrenergic stimulation in the presence of elevated calcium levels.
Authors: SKimura, J SCameron, P LKozlovskis, A LBassett, R JMyerburg
Journal: Circulation (1984)

We studied the ability of alpha-adrenergic stimulation to induce delayed afterdepolarizations and triggered activity in Purkinje fibers from cat hearts in the presence of an elevated Ca++ concentration. Delayed afterdepolarizations could not be induced at drive cycle lengths of 200 to 500 msec in the presence of extracellular Ca++ concentrations of 2.7 to 8.1 mM. However, the addition of 10(-5)M phenylephrine in the presence of 5 X 10(-7)M propranolol elicited delayed afterdepolarizations in eight of 10 preparations at a Ca++ concentration of 8.1 mM; nondrive-triggered action potentials were recorded from three of the preparations. These afterpotentials were completely suppressed by 5 X 10(-7)M prazosin or 10(-6)M phentolamine. In the presence of 5 X 10(-7)M propranolol, 10(-5)M phenylephrine prolonged action potential duration and this effect was suppressed by 5 X 10(-7)M prazosin. Methoxamine, at a concentration of 5 X 10(-6)M, was also observed to potentiate delayed afterdepolarizations in all of three...
Mechanobiology-informed regenerative medicine: Dose-controlled release of placental growth factor from a functionalized collagen-based scaffold promotes angiogenesis and accelerates bone defect healing
Authors: Eamon J. Sheehy, Gregory J. Miller, Isabel Amado, Rosanne M. Raftery, Gang Chen, Kai Cortright, Arlyng Gonzalez Vazquez, Fergal J. O'Brien
Journal: Journal of Controlled Release (2021)

Leveraging the differential response of genes to mechanical loading may allow for the identification of novel therapeutics and we have recently established placental growth factor (PGF) as a mechanically augmented gene which promotes angiogenesis at higher doses and osteogenesis at lower doses. Herein, we sought to execute a mechanobiology-informed approach to regenerative medicine by designing a functionalized scaffold for the dose-controlled delivery of PGF which we hypothesized would be capable of promoting regeneration of critically-sized bone defects. Alginate microparticles and collagen/hydroxyapatite scaffolds were shown to be effective PGF-delivery platforms, as demonstrated by their capacity to promote angiogenesis in vitro. A PGF release profile consisting of an initial burst release to promote angiogenesis followed by a lower sustained release to promote osteogenesis was achieved by incorporating PGF-loaded microparticles into a collagen/hydroxyapatite scaffold already containing directly incorporated PGF. Although this PGF-functionalized scaffold demonstrated only a modest increase in osteogenic capacity in vitro, robust bone regeneration was observed after implantation into rat calvarial defects, indicating that the dose-dependent effect of PGF can be harnessed as an alternative to multi-drug systems for the delivery of both pro-angiogenic and pro-osteogenic cues. This mechanobiology-informed approach provides a framework for strategies aimed at identifying and evaluating novel scaffold-based systems for regenerative applications.
Phase I dose escalation study of 3-weekly BI 836845, a fully human, affinity optimized, insulin-like growth factor (IGF) ligand neutralizing antibody, in patients with advanced solid tumors.
Authors: Karim Rihawi, Michael Ong, Vasiliki Michalarea, Liz Bent, Susanne Buschke, Thomas Bogenrieder, Alan Anthoney, Johann Sebastian De Bono, Chris Twelves
Journal: Journal of Clinical Oncology (2014)

2622 Background: Insulin-like growth factor signaling is reported to play a role in the pathogenesis of several tumours. BI 836845 is a HumAb of the IgG1 isotype against the human insulin-like growth factors IGF-1 and IGF-2, which are up-regulated in many tumors. This ligand-targeting approach is broader than specific IGF-1 receptor blockade. This first in man Phase I trial of 3-weekly i.v. BI 836845 was pursued to evaluate safety, tolerability, MTD and relevant biological dose (RBD). Secondary objectives included assessment of tumor response, PK and PD. Methods: Patients (pts) with advanced solid tumours, ECOG PS 0-2, and adequate organ function were recruited in a 3+3 dose escalation design. BI 836845 was administered at escalating doses in 3-weekly (21 day) cycles until progression or unacceptable toxicity. A past history of diabetes was an exclusion criterion. Results: 33 pts across 11 cohorts were enrolled and treated, median age 59.0 (23 – 79) years. Tumor types were colorectal (6), adrenal (4), NSCLC (2), head and neck (2), pancreas (2), prostate (2), ovary (2) and others (13). No DLT was observed in any of the 11 dose levels explored (range 10 to 3600 mg); MTD was not reached. The most common (> 5% of pts) related AEs were abdominal pain, constipation, decreased appetite, fatigue, lethargy and nausea all being ≤ Grade 2. 2 pts had Grade 3 related AEs (hyponatremia and diarrhea). 0 had Grade 4 related AEs. No drug-related hyperglycemia was observed. BI 836845 plasma exposure (AUC0-∞ and Cmax) increased dose-proportionally with steady state volume of distribution (Vss) of about 5.8 L and a total plasma clearance (Cl) of 0.5 mL/min. The terminal half-life was about 6 days. There were no objective responses but confirmed SD was achieved in 4 pts. RBD of 1000 mg weekly was selected based on integration of preclinical and clinical data from this study and a study investigating weekly dosing. Conclusions: BI 836845 is well tolerated in patients with advanced solid tumours. An RBD of 1000 mg weekly was identified. An expansion phase is ongoing and recruiting patients with Ewing sarcoma or all tumor types with biopsiable disease. Clinical trial information: NCT01317420.
Prognostic significance and natural history of left ventricular thrombi in patients with acute anterior myocardial infarction: a two-dimensional echocardiographic study.
Authors: PSpirito, PBellotti, FChiarella, SDomenicucci, ASementa, CVecchio
Journal: Circulation (1985)

Fifty-eight patients with transmural anterior myocardial infarction were prospectively studied with serial two-dimensional echocardiography to determine the clinical implications and prognostic significance of detection of left ventricular thrombus during acute myocardial infarction, the incidence of systemic embolization, and the possible occurrence of spontaneous regression of left ventricular thrombi. Patients were not treated with anticoagulants or platelet inhibitors during the acute phase of infarction or during follow-up. Two-dimensional echocardiograms were obtained within 24 hr of myocardial infarction, every 24 hr until day 5, every 48 hr until day 15, and every month for a follow-up of 2 to 11 months (mean 7), in the surviving patients; a total of 774 echocardiograms were obtained. Left ventricular thrombi were identified in 24 (41%) of the 58 study patients, and developed within 48 hr of infarction in 11 of these patients. Ten (91%) of the 11 patients with early thrombus formation died during ...
188TiP A phase II multicenter study of autologous tumor infiltrating lymphocytes (TIL, LN-145) cell therapy in patients with metastatic non-small cell lung cancer (mNSCLC)
Authors: E. Massarelli, Z. Goldberg, A. Cacovean, B. Yadav, G. Chen, M. Jagasia, F. Graf Finckenstein, M. Fardis, A. Sukari
Journal: Journal of Thoracic Oncology (2021)
A regurgitant jet and echocardiographic abnormalities in aortic regurgitation: an experimental study.
Authors: SNakao, HTanaka, MTahara, HYoshimura, SSakurai, CTei, TKashima
Journal: Circulation (1983)

Acute aortic regurgitation was created experimentally in 21 mongrel dogs to examine the relationship of the regurgitant jet to observed echocardiographic findings. The direction of the regurgitant jet was studied by echo contrast injections in the aortic root. Diastolic fluttering of the anterior mitral leaflet (AML) was noted in all 21 dogs irrespective of direction of the jet. Diastolic fluttering of the interventricular septum (IVS) was noted in six of the seven dogs with a tear of the noncoronary cusp and in one of seven dogs with lesions in the left coronary cusp. In all seven dogs with echocardiographically demonstrated IVS fluttering, a regurgitant jet impinged on the anterior part of the IVS. Amplitude of the AML excursion was not significantly different from control when the lesions involved the noncoronary or the left coronary cusps. However, all seven dogs that had a lesion in the right coronary cusp demonstrated a significant reduction in the amplitude of the AML excursion. The regurgitant jet...
Protective effects of retrograde compared with antegrade cardioplegia on right ventricular systolic and diastolic function during coronary bypass surgery.
Authors: E JEichhorn, J TDiehl, M AKonstam, D DPayne, D NSalem, R JCleveland
Journal: Circulation (1989)

The effect of retrograde cardioplegia delivered through the right atrium on right ventricular performance has not been critically examined in humans. We randomized 20 patients with right coronary artery lesions to receive cold blood cardioplegia solution either retrograde through the right atrium (group 1, n = 10) or antegradely (group 2, n = 10). The patients were similar in age, sex, severity of coronary artery disease, cross-clamp time, and completeness of revascularization. Before operation, right ventricular function was assessed by radionuclide ventriculography, and 18-24 hours after operation, right ventricular volumes and performance were assessed at a constant-paced heart rate by simultaneous hemodynamic-radionuclide measurements, before and after a fluid challenge. Intraoperative right ventricular temperatures were not different between the groups. Right ventricular volumes and ejection fractions were not different at baseline. After operation, at similar heart rates and loading conditions, ther...
Pathophysiology of coronary occlusion in acute infarction.
Authors: AMaseri, SChierchia, GDavies
Journal: Circulation (1986)

Coronary angiography has proved beyond doubt that complete coronary occlusion is the rule in the very early hours of infarction. The 60% to 80% rate of coronary recanalization after thrombolytic therapy has proved that thrombosis is a major component of the occlusion at the time when the procedure is performed a few hours after the onset of symptoms. However, the trigger for coronary thrombosis and the causes of failure of thrombolytic therapy are still a matter of speculation. The relatively rare occurrence of acute coronary occlusion in the life of an individual with even severe coronary disease can be explained on the basis of the necessity of either extremely powerful isolated stimuli, which only occurs rarely, or the casual simultaneous presence in one coronary arterial segment of multiple unfavorable events, such as plaque fissuring, enhanced reactivity of coronary smooth muscle to constrictor stimuli and displacement of the thrombotic-thrombolytic equilibrium toward thrombosis. Coronary artery cons...
Modulation of Ca2+ cycling in cardiac myocytes by arachidonic acid.
Authors: D SDamron, MBond
Journal: Circulation Research (1993)

It is believed that inotropic agents exert their effects in cardiac muscle via a modulation of Ca2+ cycling; however, the involvement of phospholipase activation and the biochemical pathways participating in inotropic responsiveness remain unclear. The aim of the current study was to determine whether arachidonic acid and/or eicosanoids participate in inotropic responses by modulating Ca2+ cycling in cardiac myocytes. Experiments were performed with populations of freshly isolated, fura-2-loaded adult rat ventricular myocytes. Arachidonic acid stimulated a transient increase in cytosolic free Ca2+, which was still present after addition of EGTA but was significantly reduced by pretreatment with caffeine. Addition of arachidonic acid to either electrically stimulated or quiescent myocytes enhanced the amplitude of the ATP-induced Ca2+ transient. This effect was still observed in the presence of inhibitors of cyclooxygenase, lipoxygenase, and epoxygenase pathways but was significantly diminished after pretr...
Standardized Uptake Value for 18F-Fluorodeoxyglucose Is a Marker of Inflammatory State and Immune Infiltrate in Cervical Cancer
Authors: John M. Floberg, Jin Zhang, Naoshad Muhammad, Todd A. DeWees, Matthew Inkman, Kevin Chen, Alexander J. Lin, Ramachandran Rashmi, Kay Jayachandran, Brian T. Edelson, Barry A. Siegel, Farrokh Dehdashti, Perry W. Grigsby, Stephanie Markovina, Julie K. Schwarz
Journal: Clinical Cancer Research (2021)

Abstract Purpose: Chemoradiotherapy for locally advanced cervical cancer fails in over a third of patients. Biomarkers with therapeutic implications are therefore needed. We investigated the relationship between an established prognostic marker, maximum standardized uptake value (SUVmax) on 18F-fluorodeoxyglucose positron emission tomography, and the inflammatory and immune state of cervical cancers. Experimental Design: An SUVmax most prognostic for freedom from progression (FFP) was identified and compared with known prognostic clinical variables in a cohort of 318 patients treated with definitive radiation with prospectively collected clinical data. Gene set enrichment analysis (GSEA) and CIBERSORT of whole-transcriptome data from 68 patients were used to identify biological pathways and immune cell subpopulations associated with high SUVmax. IHC using a tissue microarray (TMA, N = 82) was used to validate the CIBERSORT findings. The impact of macrophages on cervical cancer glucose metabolism was investigated in coculture experiments. Results: SUVmax &amp;lt;11.4 was most prognostic for FFP (P = 0.001). The GSEA showed that high SUVmax is associated with increased gene expression of inflammatory pathways, including JAK/STAT3 signaling. CIBERSORT and CD68 staining of the TMA showed high SUVmax tumors are characterized by a monocyte-predominant immune infiltrate. Coculture of cervical cancer cells with macrophages or macrophage-conditioned media altered glucose uptake, and IL6 and JAK/STAT3 signaling contribute to this effect. Conclusions: SUVmax is a prognostic marker in cervical cancer that is associated with activation of inflammatory pathways and tumor infiltration of myeloid-derived immune cells, particularly macrophages. Macrophages contribute to changes in cervical cancer glucose metabolism. See related commentary by Williamson et al., p. 4136
On Traumatic Cataract: With Results of Sixty Operations
Authors: J. R. Wolfe
Journal: BMJ (1872)

aind Surgery in Anderson's Univeisity.[Concuzcdcd_fronz page 67 of numfber for 3oan. 20/A;.]Opei-ative Ot//cods.-Amidstthe variety of views which prevail in regard to the operation for senile cataract, one thing is clearly made out, that many cases which were formerly considered as incurable are now no longer regarded as such.This satisfactory result has been ob- tained by our improved operative methods.But, whatever may be the ultimate position of the old flap-operation in senile cataract, it is cer- tain that in very rare exceptional cases only can it be applicable to traumatic cataract.Indeed, so long as the old method was the only one in vogue, most injured eyes were left alone, for an eye which has just received a severe injury is unfit to sustain the additional shock of a flap-operation.In order that an eye should recover sight after the removal of the lens by a large flap, it is necessary that the tissues be in a healthy condition.Now, in an eye which h1as just met with an injury causing traumatic cataract, the lens has either been simply rendered opaque, but is still adherent to its capsule, in which case a large incision will not admit of its entire removal ; or it has been partially broken up, when the fragments will come away and the rest will remain causing violent in- flammation; or the iris and ciliary circle have already been pressed upon for some days by the dislocated lens, and are, therefore, not in a condition to resist the inflammatory process caused by a large flap, but, on the contrary, wsill take part in that process, leading towards atrophy of the organ, softening, etc. Besides, in cases of traumatic cataract with a tendency to adhesion, a large incision and pressure, however gently made, is more likely to cause prolapse of the vitreous body than of the lens.Great loss of vitreous humour is also likely to be caused by the tension of the eyeball and derangement of partsand thus the object of the operation is defeated and the eye destroyed.
Reply to Dr. Mandavdhare
Authors: Chetan Mittal, Mihir S. Wagh
Journal: Endoscopy (2021)

See also: Submucosal dissection of the septum or submucosal tunneling endoscopic septum division: should we wander the free path or follow the tunnel?Endoscopy 2021; 53(04): 455-455DOI: 10.1055/a-1272-3924 See also: Practice patterns, techniques, and outcomes of flexible endoscopic myotomy for Zenker’s diverticulum: a retrospective multicenter studyEndoscopy 2021; 53(04): 346-353DOI: 10.1055/a-1219-4516
TCTAP C-051 Left Main Equivalent Bifurcation Stenting of Saphenous Venous Graft Lesion in a Patient with a Previous Rare Saphenous Venous Graft Intervention
Authors: Harinder K. Bali, Amreen Dhindsa, Navdeep Singh Sidhu, Fazal Karim, Surinder Bali
Journal: Journal of the American College of Cardiology (2021)