tbuckley/cabot-search huggingface dataset:
FRI0564 SERUM LEVELS OF IL-6 AND IL-8 IN ANKYLOSING SPONDYLITIS PATIENTS: ASSOCIATIONS WITH DISEASE ACTIVITY
Authors: E. Aleksandrova, A. Novikov, P. Kulakova, A. Dorofeev, N. Savenkova, E. Volnukhin, A. Kovshik, G. Lukina
Journal: Annals of the Rheumatic Diseases (2020)

Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease of the spine and sacroiliac joints characterized by new bone formation (syndesmophytes) and ankyloses. In AS cases, along with the damage to the musculoskeletal system, impairment of other organs and systems is often observed (uveitis, inflammatory bowel and heart diseases). Pro-inflammatory cytokines (TNF-α, IL-6,-17,-23,-21,-22,-31) and chemokines (IL-8) are key pathogenic markers in AS. Objectives: The aims of the study were to determine the serum levels of IL-6 and IL-8 in AS and investigate their relationship with disease activity. Methods: We studied 140 patients (pts) with AS fulfilled modified New York criteria (1984); (102M/38F); median and interquartile range (25th—75th percentile) of age 43.0; 35.0-51.0 years; disease duration 6.0; 4.0-12.0 years; BASDAI - 5.4; 4.1-6.6; ASDAS ESR - 3.6; 2.6-4.4; ASDAS CRP - 3.8; 2.7-4.5; 86% HLA-27 positive. In 50% of pts with AS, inflammatory bowel diseases (IBD) (Crohn’s disease and ulcerative colitis) were diagnosed. The control group included 17 healthy donors (HC). The serum concentrations of IL-6 and IL-8 were detected by chemiluminescence immunoassay using IMMULATE 1000 analyzer (Siemens Healthcare Diagnostics, USA). Results: AS pts had significantly higher serum level of IL-6 than HC (4.3; 0.1-8.0 pg/ml vs 2.3; 0.1-2.7 pg/ml, p &lt;0.006). The median concentration of IL-8 didn’t differ between AS pts and HC (10.5; 8.3-18.0 pg/ml vs 11.9; 8.2-18.3 pg/ml, p&gt;0.05). The same levels of IL-6 and IL-8 were detected in AS with IBD and AS without signs of IBD (p&gt;0.05). In AS pts, serum IL-6 concentration was positively correlated with ASDAS ESR (r = 0.3), ASDAS CRP (r = 0.3), ESR (r = 0.3) and CRP (r = 0.5) (p &lt;0.05); IL-8 was negatively associated with presence of fecal calprotectin (r = -0.3) (p &lt;0.05). Conclusion: Elevated serum concentration of IL-6 in AS is associated with clinical and laboratory markers of high inflammatory activity of the disease. The levels of IL-8 in the sera of AS patients were negatively correlated with the concentration of fecal calprotectin. Data on the relationship of IL-8 with the activity of the pathological process in AS require further study. Disclosure of Interests: Elena Aleksandrova: None declared, Alexander Novikov: None declared, Polina Kulakova: None declared, Aleksey Dorofeev: None declared, Nadezhda Savenkova: None declared, Evgeniy Volnukhin: None declared, Anton Kovshik: None declared, Galina Lukina Speakers bureau: Novartis, Pfizer, UCB, Abbvie, Biocad, MSD, Roche
SAT0158 Associates with and extent of reduced bone mineral density (bmd) in female rheumatoid arthritis (ra) patients: the oslo, truro, amsterdam (ostra) collaborative study
Authors: G Haugeberg, M Lodder, W Lems, T Uhlig, B Dijkmans, T Kvien, A Woolf
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> <h3>Objectives</h3> To examine associates with and occurrence of reduced BMD in female RA patients from three European countries. <h3>Methods</h3> 150 (50 from each country) consecutive female RA patients (ACR 1987 criteria, disease duration ≥5 yrs, age 50–70 yrs), visiting the out-patient rheumatology clinics were included. Study variables included clinical data, laboratory tests, hand X-ray (Larsen score) and BMD measurement. BMD (g/cm<sup>2</sup>) was measured by dual energy X-ray absorptiometry (DXA) and adjusted for age, weight and height. A pooled European/US reference population, showing no substantial differences with published Norwegian, English, and Dutch reference populations, was used to calculate T-scores. Groups were compared by one way ANOVA and cross tabulation (Pearson Chi square test). To investigate associates for BMD reduction bi- and multi-variety statistical analyses were performed. <h3>Results</h3> No significant differences between the countries were found for age, disease duration and rheumatoid factor, whereas weight and most disease related variables, including the use of prednisolone and treatment for osteoporosis, differed between the 3 groups. Percentage of patients having osteoporosis (T-score &lt;-2.5 SD) at femoral neck was 21.3% in Oslo, 8.3% in Truro, and 18.4% in Amsterdam (P = 0.19) and at the spine 32.0%, 18.4% and 12.0% (P = 0.04), respectively. Mean (SD) BMD values are shown in the Table 1. Using multivariate linear regression age, weight, total hand X-ray Larsen score, previous history of clinical fracture and ever use of DMARDs were independent associates for femoral neck BMD. For spine L2–4 weight, mean CRP last 12 months, ever use of DMARDs and current use of prednisolone were independent associates. <h3>Conclusion</h3> Differences in femoral neck and spine BMD might reflect differences in life styles factors, disease activity and disease management between the countries.
Abstract 14092: Age-Stratified Incidence Rates of Cardiovascular Outcomes in Both Community-Dwellers and Dialysis Patients
Authors: Masaki Ohsawa, Kozo Tanno, Kazuyoshi Itai, Yuki Yonekura, Wataru Obara, Takaya Abe, So Omori, Kuniaki Ogasawara, Motoyuki Nakamura, Yoshihiro Morino, Tomonori Itoh, Shinichi Omama, Yasuhiro Ishibashi, Yukari Yokoyama, Akira Okayama
Journal: Circulation (2017)

Introduction: To what extent dialysis patients have the higher risk of cardiovascular events than the risk in general population has not been sufficiently examined in quantitative analysis. Methods...
SAT0017 The relationship of clinical and laboratory measurements to two different radiological scoring methods in ankylosing spondylitis
Authors: S Ozgocmen, O Ardicoglu, A Kaya
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> <h3>Objectives</h3> The aim of this study was to evaluate the relationship of radiological scoring methods with clinical and laboratory measurements of the patients. Two different scoring methods -Bath Ankylosing Spondylitis Radiology Index (BASRI) and Stoke Ankylosing Spondylitis Spine Score (SASSS), which are both widely used in clinical trials- were assessed. <h3>Methods</h3> Nineteen patients (3 female, 16 male, age 22 to 41, disease duration 1 to 18 years) with AS who satisfied the modified New York criteria were included into the study. BASRI and SASSS were used to evaluate radiologic changes. Disease activity was assessed using Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). <h3>Results</h3> There was no correlation between duration of morning stiffness, night pain, laboratory variables (ESR, CRP, haemoglobin, platelets) and any of the radiological sores. No significant correlation was found between BASDAI and both of the radiological scores. BASRI and SASSS correlated significantly with occiput–to–wall distance, Schober test, and finger–to–fibula distance. There was not a significant correlation of radiologic scores with finger-to-floor distance and chest expansion. The scores of right and left SI joints correlated significantly with BASRI and SASSS. <h3>Conclusion</h3> Our results indicate that these two radiological scoring methods are measures of disease severity or deformity rather than disease activity. Radiological scoring methods are fundamental for the diagnosis and progression in AS and BASRI may be a more practical and appropriate method.
Alliance A021501: Preoperative mFOLFIRINOX or mFOLFIRINOX plus hypofractionated radiation therapy (RT) for borderline resectable (BR) adenocarcinoma of the pancreas.
Authors: Matthew H. G. Katz, Qian Shi, Jeffrey P. Meyers, Joseph M. Herman, Michael Choung, Brian M. Wolpin, Syed Ahmad, Robert de Wilton Marsh, Lawrence Howard Schwartz, Spencer Behr, Wendy L. Frankel, Eric Andrew Collisson, James Lewis Leenstra, Terence Marques Williams, Gina M. Vaccaro, Alan P. Venook, Jeffrey A Meyerhardt, Eileen Mary O'Reilly
Journal: Journal of Clinical Oncology (2021)

377 Background: Neoadjuvant therapy has been associated with a median overall survival (OS) of 18 – 23 months (mo) in patients (pts) with BR pancreatic ductal adenocarcinoma (PDAC). To establish reference regimens to which novel treatments can be compared in future studies, we evaluated neoadjuvant mFOLFIRINOX with or without RT in BR PDAC in a phase II National Clinical Trials Network (NCTN) trial. Methods: Pts with ECOG PS 0-1 and BR PDAC confirmed by central real-time radiographic review after pre-registration were randomized to either arm A: 8 cycles of neoadjuvant mFOLFIRINOX (oxaliplatin 85 mg/m 2 , irinotecan 180 mg/m 2 , leucovorin 400 mg/m 2 and infusional 5-fluorouracil 2400 mg/m 2 over 46 hours), or arm B: 7 cycles of mFOLFIRINOX followed by stereotactic body RT (SBRT, 33-40 Gy in 5 fractions [fx]) or hypofractionated image guided RT (HIGRT, 25 Gy in 5 fx). Pts in either arm without disease progression underwent pancreatectomy, then 4 cycles of adjuvant mFOLFOX6 (oxaliplatin 85 mg/m 2 , leucovorin 400 mg/m 2 and infusional 5-fluorouracil 2400 mg/m 2 over 46 hours). The primary endpoint, 18-mo OS rate, of each arm was compared to a historical control of 50%. Planned interim analysis mandated closure of either arm in which &lt;11 of first 30 accrued pts underwent R0 resection. Results: 155 pts pre-registered and 126 pts were enrolled to arm A (N=70; 54 randomized, 16 following closure of arm B) or arm B (N=56; closed at interim analysis, all pts randomized prior to closure). Median age (A: 63y, B: 67y), median CA 19-9 level (A: 171 U/ml, B: 248 U/ml) and ECOG PS (A: 51% PS 0, B: 57% PS 0) of registered pts were similar between arms (p &gt; 0.05). Treatment detailed in Table. The 18-mo OS rate based on Kaplan Meier estimates was 67.9% (95%CI: 54.6 – 78.0) in arm A and 47.3% (95%CI: 33.7 – 59.7) in arm B. Among pts who underwent pancreatectomy, 18-mo OS rate was 93.1% (95%CI: 84.3 – 100) and 78.9% (95%CI: 62.6 – 99.6) in arm A and B, respectively. With median follow-up of 27 and 31 mo, median OS was 31.0 (95%CI: 22.2 – NE) mo and 17.1 (95%CI: 12.8 – 24.4) mo in arm A and B, respectively. Conclusions: Neoadjuvant mFOLFIRINOX was associated with favorable OS relative to historical data in pts with BL PDAC in this phase II NCTN trial. mFOLFIRINOX with hypofractionated RT did not improve OS compared to historical data. mFOLFIRINOX represents a reference regimen in this setting and a backbone on which to add novel agents. Support: U10CA180821, U10CA180882, U24CA196171; https://acknowledgments.alliancefound.org Clinical trial information: NCT02839343. [Table: see text]
Common fronto-temporal effective connectivity in humans and monkeys
Authors: Francesca Rocchi, Hiroyuki Oya, Fabien Balezeau, Alexander J. Billig, Zsuzsanna Kocsis, Rick L. Jenison, Kirill V. Nourski, Christopher K. Kovach, Mitchell Steinschneider, Yukiko Kikuchi, Ariane E. Rhone, Brian J. Dlouhy, Hiroto Kawasaki, Ralph Adolphs, Jeremy D.W. Greenlee, Timothy D. Griffiths, Matthew A. Howard, Christopher I. Petkov
Journal: Neuron (2021)

Human brain pathways supporting language and declarative memory are thought to have differentiated substantially during evolution. However, cross-species comparisons are missing on site-specific effective connectivity between regions important for cognition. We harnessed functional imaging to visualize the effects of direct electrical brain stimulation in macaque monkeys and human neurosurgery patients. We discovered comparable effective connectivity between caudal auditory cortex and both ventro-lateral prefrontal cortex (VLPFC, including area 44) and parahippocampal cortex in both species. Human-specific differences were clearest in the form of stronger hemispheric lateralization effects. In humans, electrical tractography revealed remarkably rapid evoked potentials in VLPFC following auditory cortex stimulation and speech sounds drove VLPFC, consistent with prior evidence in monkeys of direct auditory cortex projections to homologous vocalization-responsive regions. The results identify a common effective connectivity signature in human and nonhuman primates, which from auditory cortex appears equally direct to VLPFC and indirect to the hippocampus.Video Abstracthttps://www.cell.com/cms/asset/0cb19785-ae66-4024-baaf-2dce151c2412/mmc5.mp4Loading ...(mp4, 19.89 MB) Download video
Monitoring and Synchronization of Cardiac and Respiratory Traces in Magnetic Resonance Imaging: A Review
Authors: Martina Ladrova, Radek Martinek, Jan Nedoma, Pavla Hanzlikova, Michael Douglas Nelson, Radana Kahankova, Jindrich Brablik, Jakub Kolarik
Journal: IEEE Reviews in Biomedical Engineering (2021)

Synchronization of human vital signs, namely the cardiac cycle and respiratory excursions, is necessary during magnetic resonance imaging of the cardiovascular system and the abdominal cavity to achieve optimal image quality with minimized artifacts. This review summarizes techniques currently available in clinical practice, as well as methods under development, outlines the benefits and disadvantages of each approach, and offers some unique solutions for consideration.
FRI0149 Serum cytokines and autoantibodies profile in rheumatoid arthritis and connective tissue diseases ? relationship to microvascular capillaroscopic abnormalities
Authors: A Kuryliszyn-Moskal, PA Klimiuk, S Sierakowski
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> Clinical manifestations of systemic vasculitis may be postulated as a consequence of the immune response abnormalities in the course of connective tissue diseases (CTD). <h3>Objectives</h3> The aim of this study was to elucidate the significance of different antibodies and proinflammatory cytokines in the diagnosis of vasculitis in patiens with rheumatoid arthritis (RA) and CTD. <h3>Methods</h3> Serum of 54 patients with RA and 32 with CTD were analysed for concentrations of TNF-alpha, IL-6, antinuclear antibodies (ANA) and ds-DNA using specific enzyme immunoassay. Anti-native DNA antibodies (nDNA) and anti-neutrophil cytoplasmic autoantibodies (ANCA) were assessed by indirect immunofluorescence test. <h3>Results</h3> Fifty out of 86 patients had systemic lesions. Pathological picture of the vascular loop in nailfold capillary microscopy was found in 84 patients. In 19 patients microvascular changes were advanced, in 35-moderate and in 30-mild. Patients with advanced changes in capillary microscopy had longer disease duration (9,7; SD = 7,4 years) compared to patients with mild intensity of vasculitis (6,1; SD = 5,7 years). Significant correlation between ANA titre and disease duration, TNF-alpha serum levels and haemoglobin concentration were observed. Presence of ANCA correlated with titer of Waaler-Rose test and erythrocyte count and of dsDNA with patient age. Serum concentration of IL-6 correlated with titer of Waaler-Rose test and CRP. RA and CTD patients with clinical signs of systemic vasculitis showed significantly higher levels of TNF-alpha, IL-6 and ANA titre as compared to those without vascular involvement. ANA and ANCA were observed significantly more frequent among patients with systemic damage compare to patients without organ injury. Also ANA were twice more frequent among patients with advanced capillaroscopic abnormalities. <h3>Conclusion</h3> These results indicate that systemic lesions in the course of RA and CTD are accompanied by abnormalities in nailfold capillary microscopy. Our findings showed correlation between presence of ANA, TNF-alpha serum levels and clinical manifestations of vasculitis. This study point to a pathogenic role of the cytokine network and autoantibodies in systemic vasculitis.
The Subject–Researcher Relationship: In Defense of Contracting Around Default Rules
Authors: Michelle N. Meyer
Journal: The American Journal of Bioethics (2011)

In this short article in the top-ranked bioethics journal, which is part of a broader project of rethinking the way we govern human subjects research, I consider a proposal to improve the quantity, quality and speed of research by requiring subjects to contractually agree not to withdraw from research, at least without good reason. That proposal would require altering the current regulations governing human subjects research, which provide subjects with an inalienable right to withdraw from the research at any time, for any reason, without penalty or loss of benefit to which they would otherwise be entitled. I argue that the gains sought by this particular proposal would likely be swamped by the costs of enforcing such contracts and by the chilling effect they would have on subject recruitment. But I agree that we should explore the role of contract in rethinking the way we govern human subjects research. Doing that in any significant way, however, requires an understanding of the subject-researcher relationship that is not fiduciary. In this article, I defend the claim that this relationship is in fact not fiduciary, cannot coherently be made fiduciary, and ought not to be fiduciary. I then defend the role of contract not only in the efficient conduct of research, but also, and more importantly, in serving the interests and welfare of research subjects.
18F-FDG PET/CT Imaging of Prostate Stromal Tumor of Uncertain Malignant Potential
Authors: Minutoli Fabio, Blandino Alfredo, Cinquegrani Antonella, Pergolizzi Stefano, Baldari Sergio
Journal: Clinical Nuclear Medicine (2021)

A 79-year-old man presented with dysuria and increased serum prostate-specific antigen level (21 ng/mL). MRI revealed bulky prostate enlargement but was inconclusive in revealing neoplastic lesions. Nevertheless, because of high clinical suspicion for neoplasm, transrectal biopsy revealed stromal tumor of uncertain malignant potential mixed with foci of low-grade primitive prostate stromal sarcoma. 18F-FDG PET/CT showed high FDG uptake consistent with neoplasm in the lower part of the hypertrophic prostate gland and focal areas of elevated FDG uptake, consistent with metastases in the spine, ribs, and femur.
Fglutamyl transferase elevations are frequent in patients with COVID-19: A clinical epidemiologic study
Authors: T. Shao, Y. Tong, A. Jeyarajan, W. Lin, R. T. Chung
Journal: Hepatology (2020)

Background: A newly identified coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the infectious coronavirus disease 2019 (COVID-19), emerged in December 2019 in Wuhan, Hubei Province, China and now poses a major threat to global public health Previous studies have observed highly variable alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in patients with COVID-19 However, circulating levels of the cholangiocyte injury biomarker γ-glutamyl transferase (GGT) have yet to be reported in the existing COVID-19 case studies Herein, we describe the relationship between GGT levels and clinical and biochemical characteristics of patients with COVID-19 Methods: Retrospective case series of 98 consecutive hospitalized patients with confirmed COVID-19 at Wenzhou Central Hospital in Wenzhou, China, from January 17 to February 5, 2020 Clinical data were collected using a standardized case report form Diagnosis of COVID-19 was assessed by symptomatology, RT-PCR, and CT scan The medical records of patients were analyzed by the research team Results: Of the 98 patients evaluated, elevated GGT levels were observed in 32 7%;increased C-reactive protein (CRP), elevated ALT and AST levels were observed in 22 5%, 13 3% and 20 4% respectively;elevated alkaline phosphatase (ALP) and triglycerides (TG) were found in 2% and 21 4% respectively  Initially, age >40 years (p=0 02), male gender (p=0 005), elevated CRP (p=0 0184), ALT (p=0 0001), ALP (p=0 0002) and increased TG (p=0 0006) were found to be associated with elevated GGT levels Conclusion: A sizable number of patients with COVID-19 infection had elevated serum GGT levels This elevation supports involvement of the liver in persons with COVID-19
Direct activation of the aryl hydrocarbon receptor by dog allergen participates in airway neutrophilic inflammation
Authors: Mélodie Bouté, Saliha Ait Yahia, Julie Nanou, Daniel Alvarez‐Simon, Camille Audousset, Han Vorng, Joanne Balsamelli, Fan Ying, Philippe Marquillies, Elisabeth Werkmeister, Patricia de Nadai, Cécile Chenivesse, Anne Tsicopoulos
Journal: Allergy (2021)

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Role of DNA polymerases family members in cancer: The pan-cancer perspective.
Authors: Zhiwen Luo, Xinyu Bi, Xingang Bi
Journal: Journal of Clinical Oncology (2021)

475 Background: DNA polymerases family (DNA pols) has a lengthy reported significant influence on the initiation, development, and progress of cancer. However, the pan-cancer value of whole family members was poorly done. Our study intends to demonstrate the expression pattern and clinical cancer value of DNA pols members as prognostic biomarkers and a therapeutic target of pan-cancer. Methods: Comprehensive bioinformatics analyses were done using data from TCGA and CCLE. MultiCox regression was done to select tumor prognosis-related members. Nomogram was constructed to predict the overall survival (OS) across cancer patients. Transcription factor, GO, IPA, and GSEA enrichments were done to explore regulatory mechanisms and functions. Results: A total of 22 DNA pols were identified to have a potential to diagnostic value, and 10 DNA pols have a pan-cancer prognostic value under various stages, and cancer type, among which overexpression of 6 DNA-pols (POLA2, POLD1, POLD2, POLE2, POLE4, and POLQ) was found to be significantly related to worse outcomes regarding OS, while 4 DNA-pols (POLH, POLL, POLN, and REV1) significantly related to better outcomes. A 5-DNA pols based risk score (POLQ, POLD2, POLL, POLH, and REV1) was generated by MultiCox regression with a nomogram validated an accurate predictive efficacy. MYB Proto-Oncogene Like 2 (MYBL2) was identified as transcription factors of prognostic DNA pols in pan-cancer, and IPA mimic experiment reveals inhibiting MYBL2 could be a drug target to recover and balance the dysregulated expression pattern of DNA pols in pan-cancer. GO, IPA, and GSEA enrichments revealed functions and pathways altered by DNA pols in cancer, and the results were supported by pan-cancer cell sequencing data. Conclusions: DNA pols have a pan-cancer clinical value and can work as potential prognostic biomarkers. Furthermore, MYBL2 could be a drug target for pan-cancer.