tbuckley/cabot-search huggingface dataset:
Global 30-day outcomes after bariatric surgery during the COVID-19 pandemic (GENEVA): an international cohort study
Authors: Rishi Singhal, Abd A Tahrani, Christian Ludwig, Kamal Mahawar, A Abou-Mrad-Fricquegnon, A Alasfur, A Alexandrou, A Barbosa, A Bashir, A Bosco, A Charalabopoulos, A Curell, A Davarpanah Jazi, A Diego, A Elghandour, A Ergin, A Garcia, A Ghazal, A Haddad, A Ibarzábal, A Khazraji, A Lale, A Lázaro, A Leyva-Alvizo, A Liagre, A Maleckas, A Osman, A Pantelis, A Pazouki, A Plamper, A Raziel, A Rizzi, A Sanchez, A Sharma, A Spaventa, A Sumer, A Torres, A Türkçapar, A Ugale, A Velikorechin, A Vitiello, B Alkhaffaf, B Bomans, BJ Ammori, B Pares, B Smeu, B Zilberstein, C Boeker, C Brodén, C Copaescu, C Guevara, C Güldoğan, C Kirkil, C Matthys, C Nagliati, C Parmar, C Trindade, C Vaz, C Wietzycoski, C Zerrweck, D Bedi, D de Marchi, D Faraj, D Foschi, D Goitein, D Hazzan, D Lapatsanis, D Mazza, D Mohammed, D Padilla-Armendariz, D Pennisi, D Pham, D Pournaras, D Swank, D Thakkar, E Baena, E Baili, E Bastos, E Dilektasli, E Hazebroek, E Kaplan, E Lopes, E Manno, E Pinotti, E Sdralis, F Barrera-Rodriguez, F Cantu, F Frattini, F Martini, G Berardi, G Cesana, G Dapri, G Dinescu, G Juglard, G Martinez de Aragon, G Menaldi, G Ören, G Pavone, G Rana, G Vrakopoulou, H Aboshanab, H Al-Momani, H Balamoun, H Çiyiltepe, H de Vasconcelos Cunha, H Elghadban, H Gislason, H Hamed, H Hamed, H Heneghan, H Ibrahim, H Melali, H Reyes, H Sebbag, I Hakami, I Hutopila, J Balibrea, J Bernardo, J Campos, J Chevallier, J Dargent, J Estrada, J Gonzalez, J Hewes, J Himpens, J Mall, J Monterrubio, J Pasquier, K Albanopoulos, K Bartosiak, K Kaseja, K Kumar, K Rheinwalt, K Shah, K. van de Pas, L Angrisani, L Benuzzi, L Chong, L Layani, L Lee, L Level, L Taylor, L Zinai, M Akbaba, M Alejandro, M Altarawni, M Beisani, M Bertrand, M Cantu, M Dincer, M Elbanna, M Elfawal, M Focquet, M Forero, M Hadad, M Hii, M Iovino, M Islam, M Josa, M Kaplan, M Kermansaravi, M Khaitan, M Kizilkaya, M Kotowski, M Montouri, M Musella, M Narwaria, M Navarro, M Niazi, M Özmen, M Qassem, M Romeijn, M Said, M Salman, M Solovyeva, M Takieddine, M Uccelli, M Ustun, M Valeti, M Walędziak, N Arora, N Dukkipati, N Fearon, N Kiran, N Paleari, N Sakran, N Silva, N Tartaglia, O Savas, O Şen, O Viveiros, P Fabbri, P García, P Major, P Martinez, P Martinez Duartez, P Salminen, P Shah, R Gadani, R Gokay, R Gudaityte, R Kassir, R Liem, R Mohan, R Palma, R Quinino, R Ribeiro, R Vilallonga, S Arana-Garza, S Chiappetta, S Davakis, S Ghareeb, S Gregorio, S Khaldi, S Martinez, S Okkema, S Olmi, S Ortiz, S Pinango, S Shah, S Shahabi, S Taha, S Ugale, T Barreiro, T Beck, T Poghosyan, T Samarkandy, T Yigit, V Borrelli, V Bottino, V Marco, V Ormando, V Pol, V Sierra Esteban, V Valentí, W Leclercq, W Souza, W Vening, W Vleeschouwers, Y van der Burgh
Journal: The Lancet Diabetes & Endocrinology (2020)
A tribute to some of the doctors who died from COVID-19
Authors: Andrew Green
Journal: The Lancet (2020)

The global COVID-19 death toll stands at more than 1·3 million. Among the lives lost have been those of health-care workers, who have had crucial roles throughout the response and continue to serve at the front lines. At the outset of the pandemic, doctors warned of the potential implications of the virus. As the virus spread, many doctors provided treatment for a disease they little understood, while others contributed to accelerated research on potential treatments and vaccines. And as the COVID-19 pandemic worsened worldwide, health professionals worked tirelessly to provide care for patients—some even emerged from retirement to provide assistance.
Use of the Implantable Cardioverter-Defibrillator in Patients With Coronary Artery Spasm as the Apparent Cause of Spontaneous Life-Threatening Ventricular Tachycardia or Ventricular Fibrillation: Crossing the Spasm Sudden Death Chasm⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Authors: L. Brent Mitchell
Journal: Journal of the American College of Cardiology (2012)
16825 Passively collected data from smartphones correlate with subjective disease severity in atopic dermatitis
Authors: Aleksander Eiken, Charlotte Amalie Pind Laugesen, Ari Páll Ísberg, Andrei Chiriac, Ana-Maria Dutei, Irina Deaconescu, Ionela Manole, Teske Valk, Anders Daniel Andersen, John R. Zibert
Journal: Journal of the American Academy of Dermatology (2020)
Abstract 15979: Cardiac Toxicity of Flavorings in Electronic Nicotine Delivery Systems
Authors: Obada Abou-Assali, Michelle Reiser, Charles Szekeres, Sami Noujaim
Journal: Circulation (2019)

Introduction: Electronic Nicotine Delivery Systems (ENDS) are very popular amongst teens and young adults. They are marketed as safe alternatives to tobacco cigarettes. However, the possible advers...
Postwar Planning in Anesthesiology
Authors: Henry S. Ruth
Journal: New England Journal of Medicine (1944)

ANESTHESIOLOGY has now established its 1~\. unequivocal value to the surgical and medical professions, and to those seeking medical care coming under its jurisdiction. The inherent dynamic nature of the specialty with its present broad application was gaining momentum rapidly during the immediate prewar period. Its increasing sphere of application was being affected less and less in those days by specious economic opposition and examples of personal and institutional obstacles. A permanent retardation of its growth because of the temporary remission of its activities in civilian life engendered by the war is therefore not expected. Conversely, its growth may be further stimulated in the post-
Large Deletions and Novel Mutations in Genes Coding for Ribosomal Proteins (RPL11, RPL35A, RPS19) in the Czech National Registry of Diamond-Blackfan Anemia (DBA)
Authors: Jana Volejnikova, Petr Vojta, Zuzana Maceckova, Pavla Koralkova, Helena Urbankova, Monika Horvathova, Barbora Ludikova, Martina Sukova, Pavel Timr, Marian Hajduch, Dagmar Pospisilova
Journal: Blood (2017)
Coronary Computed Tomography Angiography in the Emergency Department: The High Stakes Game of Low Risk Chest Pain⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Authors: Wm. Guy Weigold
Journal: Journal of the American College of Cardiology (2013)
The Changing Epidemiology of Infective Endocarditis: The Paradox of Prophylaxis in the Current and Future Eras⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Authors: Andrew Wang
Journal: Journal of the American College of Cardiology (2012)
Workplace physical activity promotion: why so many failures and few successes? The need for new thinking
Authors: Andreas Holtermann, Leon Straker, I-Min Lee, Emmanuel Stamatakis, Allard J van der Beek
Journal: British Journal of Sports Medicine (2020)

Work has been a major determinant of adult physical activity throughout most of history. Yet public health initiatives and guidelines have traditionally focused on promoting physical activity during leisure time; the workplace has received limited attention.1 In this editorial, we: (1) argue why the workplace offers a great potential for promoting physical activity in working populations, (2) discuss reasons for the many failures, (3) share success stories and (4) suggest a new approach to unleash the great potential of workplace physical activity initiatives.
What comes after the lockdown? Clustering of ANCA-associated vasculitis: single-centre observation of a spatiotemporal pattern
Authors: Philipp Gauckler, Erica L Bettac, Manfred Nairz, Christina Duftner, Anna K Luger, Markus Stein, David Wanner, Barbara C Böckle, Martin Tiefenthaler, Peter Schratzberger, Hannes Neuwirt, Lukas Harasser, Gert Mayer, Andreas Kronbichler
Journal: Annals of the Rheumatic Diseases (2020)

Antineutrophil cytoplasm antibodies (ANCA)-associated vasculitides (AAV) are characterised by a heterogeneous clinical phenotype.1 We report a cluster of 15 patients diagnosed with AAV either de novo (n=11) or with relapsing disease (n=4) during COVID-19 pandemic between February and August 2020. During this period, we observed two major phenomena: (1) an incidence-shift with a ‘COVID-gap’ of no diagnosed AAV cases during the lockdown period (March and April), followed by a ‘postlockdown cluster’ of 14 active patients (8 myeloperoxidase-ANCA, 6 proteinase 3-ANCA vasculitis) in the subsequent 4 months and (2) an increased incidence rate (figure 1 and online supplemental figure S3). Mean creatinine at baseline was 3.66 mg/dL. Inflammatory markers were significantly elevated in most patients, with a mean C reactive protein value of 9.93 mg/dL and an erythrocyte sedimentation rate of 83 mm per first hour. Despite detrimental effects on humoral immunity,2 most patients received two doses of rituximab and methylprednisolone. No severe treatment complications occurred. SARS-CoV-2 PCR and serology were negative in tested patients. Further clinical and radiological characteristics are provided in online supplemental tables S1 and S2).### Supplementary data

[annrheumdis-2020-219212supp001.pdf] 

### Supplementary data

[annrheumdis-2020-219212supp002.pdf] 

### Supplementary data

[annrheumdis-2020-219212supp003.pdf] 

### Supplementary data

[annrheumdis-2020-219212supp004.pdf] 



Figure 1 
Timeline of incident ANCA-associates vasculitis cases in 2018, 2019 and 2020. Incident cases are posed on a timeline …
The evolution of relapse of adult T cell acute lymphoblastic leukemia
Authors: Inés Sentís, Santiago Gonzalez, Eulalia Genescà, Violeta García-Hernández, Ferran Muiños, Celia Gonzalez, Erika López-Arribillaga, Jessica Gonzalez, Lierni Fernandez-Ibarrondo, Loris Mularoni, Lluís Espinosa, Beatriz Bellosillo, Josep-Maria Ribera, Anna Bigas, Abel Gonzalez-Perez, Nuria Lopez-Bigas
Journal: Genome biology (2020)

Abstract Background Adult T cell acute lymphoblastic leukemia (T-ALL) is a rare disease that affects less than 10 individuals in one million. It has been less studied than its cognate pediatric malignancy, which is more prevalent. A higher percentage of the adult patients relapse, compared to children. It is thus essential to study the mechanisms of relapse of adult T-ALL cases. Results We profile whole-genome somatic mutations of 19 primary T-ALLs from adult patients and the corresponding relapse malignancies and analyze their evolution upon treatment in comparison with 238 pediatric and young adult ALL cases. We compare the mutational processes and driver mutations active in primary and relapse adult T-ALLs with those of pediatric patients. A precise estimation of clock-like mutations in leukemic cells shows that the emergence of the relapse clone occurs several months before the diagnosis of the primary T-ALL. Specifically, through the doubling time of the leukemic population, we find that in at least 14 out of the 19 patients, the population of relapse leukemia present at the moment of diagnosis comprises more than one but fewer than 10 8 blasts. Using simulations, we show that in all patients the relapse appears to be driven by genetic mutations. Conclusions The early appearance of a population of leukemic cells with genetic mechanisms of resistance across adult T-ALL cases constitutes a challenge for treatment. Improving early detection of the malignancy is thus key to prevent its relapse.
Biofunctionalization of 3D-printed silicone implants with immunomodulatory hydrogels for controlling the innate immune response: An in vivo model of tracheal defect repair
Authors: J. Barthes, P. Lagarrigue, V. Riabov, G. Lutzweiler, J. Kirsch, C. Muller, E.-J. Courtial, C. Marquette, F. Projetti, J. Kzhyskowska, P. Lavalle, N.E. Vrana, A. Dupret-Bories
Journal: Biomaterials (2020)
Abstract 14059: A Digital Health Intervention to Improve Physical Activity After Cardiac Rehabilitation: The Mobile4heart Clinical Trial
Authors: Linda G Park, Abdelaziz Elnaggar, Stephanie Merek, Charles E McCulloch, Mary A Whooley
Journal: Circulation (2019)

Introduction: Cardiac rehabilitation (CR) is an exercise-based program prescribed after cardiac events that is associated with improved physical, mental, and social functioning; however, as few as ...
Prognostic Value of B‐Type Natriuretic Peptide in Liver Transplant Patients: Implication in Posttransplant Mortality
Authors: Hye‐Mee Kwon, Young‐Jin Moon, Kyoung‐Sun Kim, Won‐Jung Shin, In‐Young Huh, In‐Gu Jun, Jun‐Gol Song, Gyu‐Sam Hwang
Journal: Hepatology (2020)

Background and Aims Despite frequent cirrhotic cardiomyopathy or subclinical heart failure (HF), the prognostic value of peri–liver transplant (LT) B‐type natriuretic peptide (BNP) has been poorly studied in advanced liver disease. We examined the association between BNP and mortality in a large cohort of LT patients and identified risk factors for peri‐LT BNP increase. Approach and Results Using prospectively collected data from the Asan LT Registry between 2008 and 2019, 3,811 patients who measured serial pretransplant BNP (preBNP) and peak BNP levels within the first 3 posttransplant days (postBNP POD3 ) were analyzed. Thirty‐day all‐cause mortality predicted by adding preBNP and/or postBNP POD3 to the traditional Revised Cardiac Risk Index (RCRI) was evaluated. PreBNP &gt; 400 pg/mL (known cutoff of acute HF) was found in 298 (7.8%); however, postBNP POD3 &gt; 400 pg/mL was identified in 961 (25.2%) patients, specifically in 40.4% (531/1,315) of those with a Model for End‐Liver Disease score (MELDs) &gt; 20. Strong predictors of postBNP POD3 &gt; 400 pg/mL were preBNP, hyponatremia, and MELDs, whereas those of preBNP &gt; 400 pg/mL were MELDs, kidney failure, and respiratory failure. Among 100 (2.6%) post‐LT patients who died within 30 days, patients with postBNP POD3 ≤ 150 pg/mL (43.1%, reference group), 150‐400 pg/mL (31.7%), 400‐1,000 pg/mL (18.5%), 1,000‐2,000 pg/mL (4.7%), and &gt;2,000 pg/mL (2.0%) had 30‐day mortalities of 0.9%, 2.2%, 4.0%, 7.7%, and 22.4%, respectively. Adding preBNP, postBNP POD3 , and both BNP to RCRI improved net reclassification index to 22.5%, 29.5%, and 33.1% of 30‐day mortality, respectively. Conclusions PostBNP POD3 &gt; 400 pg/mL after LT was markedly prevalent in advanced liver disease and mainly linked to elevated preBNP. Routine monitoring of peri‐LT BNP provides incremental prognostic information; therefore, it could help risk stratification for mortality as a practical and useful biomarker in LT.
52P Chemotherapy selection in routine clinical practice in Japan for HER2-negative advanced or metastatic breast cancer (KBCRN A001: E-SPEC Study)
Authors: Y. Kang, Y. Kikawa, T. Kotake, S. Tsuyuki, S. Takahara, H. Yamashiro, H. Yoshibayashi, M. Takada, R. Yasuoka, K. Yamagami, H. Suwa, T. Okuno, I. Nakayama, T. Kato, Y. Moriguchi, H. Ishiguro, T. Kagimura, T. Taguchi, T. Sugie, M. Toi
Journal: Annals of Oncology (2020)
Effects of caloric restriction on immunosurveillance, microbiota and cancer cell phenotype: Possible implications for cancer treatment
Authors: Francesca Pistollato, Tamara Yuliett Forbes-Hernandez, Ruben Calderón Iglesias, Roberto Ruiz, Maria Elexpuru Zabaleta, Irma Dominguez, Danila Cianciosi, Josè L. Quiles, Francesca Giampieri, Maurizio Battino
Journal: Seminars in Cancer Biology (2020)
360P Number of lymph nodes examined was not an independent risk factor for the survival of patients with stage IA1-2 lung adenocarcinoma undergoing sublobar resection
Authors: Z. Qiu, C. Zhang, X. Yang, W. Tang, R. Fu, H. Hong, X. Yang, Q. Nie, Y-L. Wu, W-Z. Zhong
Journal: Annals of Oncology (2020)
Abstract 19364: Coronary Plaque Characteristics by Age and Sex in Healthy Individuals with a Family History of Early-Onset Coronary Artery Disease
Authors: Brian G Kral, Diane M Becker, Dhananjay Vaidya, Lisa R Yanek, Rehan Qayyum, Taryn F Moy, Elliot K Fishman, Lewis C Becker
Journal: Circulation (2012)

Background: Although calcified coronary plaque (CCP) increases with age and is more prevalent in males, the extent to which noncalcified plaque (NCP) is present across the age range of both sexes is unknown. This has important implications for primary prevention guidelines, particularly in high risk populations, since NCP is a putative immediate precursor for coronary artery disease (CAD) events. We thus examined total coronary plaque (TCP), CCP, and NCP distributions in healthy male and female first degree relatives of persons with early-onset CAD. Methods: Participants in GeneSTAR (N=561), mean age 51.5 ± 10.8 years, range 30 to 75 years, 58% female, were screened for coronary plaque using 256 multidetector dual-source CT angiography. Segmental plaque volumes (mm3) were quantified using an automated well-validated proprietary method and summed for CCP and NCP. TCP was calculated from CCP+NCP. Results: Males had a higher prevalence of any coronary plaque compared to females, (58.1% vs 36.7% respectively, p&lt;0.0001); plaque prevalence increased significantly with age (Table). However, females more often had only NCP than males, (17.6% vs 8.9%, p= 0.11). CCP and NCP volumes both increased with age in both sexes, but NCP accounted for more than half of TPV in both sexes at all ages; NCP represented more than 80% of TPV in subjects &lt;55 years of age. Conclusion: The majority of TPV was noncalcified plaque in this healthy high risk population, particularly in females and in males &lt;55 years old. Thus, conditioning aggressive primary prevention on traditional coronary calcium scoring algorithms, may obviate appropriate risk reduction interventions in young persons with a family history of early onset-CAD. Table: Sex-specific noncalcified and calcified coronary plaque volumes by age group (median [IQR])
心筋潅流の回復の遅れと治療抵抗性狭心症患者における心筋内レーザー血行再建術(TMLR)後の症状緩和に関連する心機能
Authors: Eguchi M, Nakata T, Kawashima T, Ohhori K, Ichikawa K, Fujiwara T, Shimamoto K
Journal: Circulation (1999)
Abstract IA30: Targeting MYC deregulation in cancer
Authors: Gregor A. Lueg, Monica Faronato, Andrii Gorelik, Andrea G. Grocin, Miriam Llorian-Sopena, Probir Chakravarty, Bernadette Brzezicha, Martin Janz, Mathew J. Garnett, Dinis P. Calado, Edward W. Tate
Journal: Blood Cancer Discovery (2020)

Abstract Human N-myristoyltransferase (NMT) 1 and 2 catalyze N-terminal protein myristoylation, a modification that regulates membrane trafficking and interactions of &amp;gt;100 proteins. NMT has been proposed as a target in cancer, but a rationale for selectivity is lacking due to the complex impact of NMT inhibition (NMTi) on multiple cellular pathways. Here, large-scale screens of hundreds of cancer cell lines against a panel of potent and selective NMTi were combined with systems-level analyses to reveal that NMTi is synthetically lethal with deregulated MYC or MYCN. Synthetic lethality is mediated by post-transcriptional failure in (NADH) Complex I protein synthesis followed by mitochondrial dysfunction in MYC-deregulated cancer cells. We observed that NMT inhibitors blocked the growth of patient-derived tumors with deregulated MYC, without overt toxicity. This mechanistic framework supports NMTi as a novel targeted therapeutic approach and provides a new paradigm in which targeting of a constitutive protein modification is synthetically lethal in MYC-deregulated cancers. Citation Format: Gregor A. Lueg, Monica Faronato, Andrii Gorelik, Andrea G. Grocin, Miriam Llorian-Sopena, Probir Chakravarty, Bernadette Brzezicha, Martin Janz, Mathew J. Garnett, Dinis P. Calado, Edward W. Tate. Targeting MYC deregulation in cancer [abstract]. In: Proceedings of the AACR Virtual Meeting: Advances in Malignant Lymphoma; 2020 Aug 17-19. Philadelphia (PA): AACR; Blood Cancer Discov 2020;1(3_Suppl):Abstract nr IA30.
Identification of a novel ATM acetylation site required for activation of ATM’s kinase activity.
Authors: Yingli Sun, Ye Xu, Kanaklata Roy, Brendan Price
Journal: Cancer Research (2007)

1106  The ATM protein kinase is mutated in the inherited disease ataxia-telangiectasia. ATM’s kinase activity is rapidly activated by DNA double strand breaks. Activated ATM then regulates the cell’s response to DNA damage through the phosphorylation of proteins involved in both cell-cycle checkpoints and DNA repair. The signal-transduction pathway linking the detection of DNA strand breaks to activation of ATM’s kinase activity is not clearly defined. Previous work demonstrated that the efficient activation of ATM required interaction with the MRN DNA binding complex, and that autophosphorylation of serine 1981 of ATM may play a key role in converting inactive ATM dimers into active ATM monomers. Recently, we demonstrated that ATM activation involved acetylation of ATM by the Tip60 acetyltransferase. Here, we report on the identification and characterization of a unique lysine residue on ATM which is inducibly acetylated by Tip60 in response to DNA damage. The ATM acetylation site was identified by combining deletion analysis and mutagenesis of the ATM protein, and by employing an acetyl-lysine specific antibody which detects acetylated lysine residues independently of the surrounding sequence. A single, highly conserved lysine was identified which accounted for all of the immunodetectable acetylation of the ATM protein. Mutation of the ATM-acetylation site from lysine to arginine abolished DNA damage-induced ATM autophosphorylation and blocked the ability of ATM to complement the increased radiosensitivity of A-T cells to DNA damage. A sequence-specific antibody raised against this site detected DNA-damage induced acetylation of this lysine residue. Further, this conserved lysine residue was acetylated by Tip60 both in vivo and in vitro, and was dependent on functional Tip60 and MRN complex. We conclude that there is at least one functionally important DNA damage-induced acetylation event in ATM, and we propose a mechanism in which the initial step in the activation of ATM’s kinase activity is the inducible acetylation of the ATM protein.
41P Mir-223 overexpression is associated with increased expression of EGFR and worse prognosis in Indonesian TNBC patients
Authors: I. Purwanto, D.S. Heriyanto, I. Widodo, S.H. Hutajulu, M.S. Hardiyanti, J. Kurnianda, K.W. Taroeno-Hariadi, B. Leo, A.D. Satiti, R.Y. Purwanto, K.R. Qurania, T. Aryandono, S.M. Haryana
Journal: Annals of Oncology (2020)
14115 Effects of ultrafrequency on abdominal adiposity
Authors: Patricia Meyer, Rodrigo Marcel Valentim da Silva, Eneida Carreiro, Liliane Santos de Vasconcellos, Fábio Dos Santos Borges, Aline Brito Ferreira de Castro, Jania Cacilda Santos, Waleska Carvalho
Journal: Journal of the American Academy of Dermatology (2020)
What Caring for My Aging Parents Taught Me That Medical Education Did Not
Authors: David I. Rappaport
Journal: JAMA Neurology (2020)

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