tbuckley/cabot-search huggingface dataset:
Response to Cold of Eskimos of the Eastern Canadian Arctic
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases
Authors: Rebecca S. Muraoka, Nancy Dumont, Christoph A. Ritter, Teresa C. Dugger, Dana M. Brantley, Jin Chen, Evangeline Easterly, L. Renee Roebuck, Sarah Ryan, Philip J. Gotwals, Victor Koteliansky, Carlos L. Arteaga
Journal: Journal of Clinical Investigation (2002)

TGF-βs are potent inhibitors of epithelial cell proliferation. However, in established carcinomas, autocrine/paracrine TGF-β interactions can enhance tumor cell viability and progression. Thus, we studied the effect of a soluble Fc:TGF-β type II receptor fusion protein (Fc:TβRII) on transgenic and transplantable models of breast cancer metastases. Systemic administration of Fc:TβRII did not alter primary mammary tumor latency in MMTV-Polyomavirus middle T antigen transgenic mice. However, Fc:TβRII increased apoptosis in primary tumors, while reducing tumor cell motility, intravasation, and lung metastases. These effects correlated with inhibition of Akt activity and FKHRL1 phosphorylation. Fc:TβRII also inhibited metastases from transplanted 4T1 and EMT-6 mammary tumors in syngeneic BALB/c mice. Tumor microvessel density in a mouse dorsal skin window chamber was unaffected by Fc:TβRII. Therefore, blockade of TGF-β signaling may reduce tumor cell viability and migratory potential and represents a testable therapeutic approach against metastatic carcinomas.
Hormones and growth factors in milk
Authors: C. E. Grosvenor
Journal: Endocrine Reviews (1993)

Journal Article Hormones and Growth Factors in Milk Get access Clark E. Grosvenor, Clark E. Grosvenor 1Departments of Molecular and Cellular Biology (C.E.G.), Nutrition (M.F.P.), and Dairy and Animal Science (C.R.B.), The Pennsylvania State University, University Park, Pennsylvania 16802 *Address requests for reprints to: Clark E. Grosvenor, Ph.D., Department of Molecular and Cellular Biology, Pennsylvania State University, 6 Althouse Laboratory, University Park, Pennsylvania 16802. Search for other works by this author on: Oxford Academic Google Scholar Mary Frances Picciano, Mary Frances Picciano 1Departments of Molecular and Cellular Biology (C.E.G.), Nutrition (M.F.P.), and Dairy and Animal Science (C.R.B.), The Pennsylvania State University, University Park, Pennsylvania 16802 Search for other works by this author on: Oxford Academic Google Scholar Craig R. Baumrucker Craig R. Baumrucker 1Departments of Molecular and Cellular Biology (C.E.G.), Nutrition (M.F.P.), and Dairy and Animal Science (C.R.B.), The Pennsylvania State University, University Park, Pennsylvania 16802 Search for other works by this author on: Oxford Academic Google Scholar Endocrine Reviews, Volume 14, Issue 6, 1 December 1993, Pages 710–728, https://doi.org/10.1210/edrv-14-6-710 Published: 01 December 1993
The Cover
Authors: Kathleen A. Foster
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOVINE AND HUMAN TUBERCULOSIS.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Typhoid Fever.
Authors: Edwin A. Carpenter
Journal: JAMA (1905)

Baileyville, Ill., April 8, 1905. <h3>To the Editor:</h3> —The article on typhoid fever by Dr. Robin of Wilmington, Del., inThe JournalApril 8, 1905, leads me to quote from "Report on the Origin and Spread of Typhoid Fever in U. S. Military Camps During Spanish War of 1898." The letter of transmittal states that data "furnish most positive proof that the dissemination of typhoid fever in the military camps in 1898 was largely from person to person by contact and not through infected food or water." The study of the conditions prevalent at Jacksonville convinced the board that there, at least, water was not responsible for the epidemic; then the inspection of the recently abandoned camps at Chickamauga plainly told the truth, and the fact that the most potent factor in the spread of typhoid fever in the camps was the pollution of the soil, of the feet, clothing,
Aging heart adapts to change; researchers begin to unravel some mechanisms involved
Authors: P. Gunby
Journal: JAMA (1995)

ADAPTATION is the key word in the view of some researchers studying the aging heart today. The theory is that the older heart adapts to specific deficits in performance through compensatory adjustments in its other functional characteristics. Therefore, National Institute on Aging (NIA) researchers like Edward G. Lakatta, MD, Jerome L. Fleg, MD, and colleagues are seeking to unravel the aging heart's adaptive mechanisms. They are addressing adaptive changes in: Cardiac structure and resting performance; Response to acute and chronic stresses; and Sympathetic modulation of cardiovascular function. <h3>Costly to Older Persons' Health</h3> Richard J. Hodes, MD, the NIA's director on the parent National Institutes of Health (NIH) campus, Bethesda, Md, notes that cardiovascular disease accounts for four or more of every 10 deaths among persons in this country aged 65 to 74 years. In a recent NIA booklet (NIH publication 94-3738) on cardiovascular aging, Hodes writes that "research on the
MEDICAL MAKESHIFTS.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical News
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Oral Thyroxine
Authors: JOACHIM BOEHLER
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 October 1984Oral ThyroxineJOACHIM BOEHLER, M.D.JOACHIM BOEHLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-4-572 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Sawin and colleagues (1) conclude in their recent article, "In the meantime [until the thyroxine content is known to be as stated], a reasonable course would be to use an oral thyroxine preparation that is known to contain approximately its stated content."I question the basis and ethics (2) of this conclusion favoring a switch to Levothroid (Armour Pharmaceutical Co., Kankakee, Illinois). A switch to a more potent thyroid preparation might be dangerous for patients who have reached a steady state on their current regimen. Ramos-Gabatin (3) found not only the expected change in thyroid function tests...References1. SAWINSURKSLONDONRANGANATHANLARSEN CMMCP. Oral thyroxine: variation in biologic action and tablet content. Ann Intern Med. 1984;100:641-5. LinkGoogle Scholar2. RELMAN A. Dealing with conflicts of interest. N Engl J Med. 1984;310:1182-3. CrossrefMedlineGoogle Scholar3. RAMOS-GABATIN A. In vivo comparison of levothyroxine preparations JAMA. 1982;247:203-5. CrossrefMedlineGoogle Scholar4. STOFFER S. Potency of brand name and generic levothyroxine products. JAMA. 1980;244:1704-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Abbott Northwestern Hospital Minneapolis, MN 55407 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1984Volume 101, Issue 4Page: 572-573KeywordsThyroidThyroxine Issue Published: 1 October 1984 PDF DownloadLoading ...
St Louis Encephalitis Outbreak—Arkansas, 1991
Journal: JAMA (1991)

On August 2, 1991, a neurologist in Pine Bluff (Jefferson County) in central Arkansas notified the Arkansas Department of Health of two patients hospitalized with St. Louis encephalitis (SLE). A hospital chart review and heightened surveillance (i.e., notification of physicians and hospital infection-control coordinators in Jefferson and surrounding counties) subsequently identified 24 confirmed or probable cases of SLE. This report summarizes the findings of the ongoing outbreak investigation.
Radiography in the Examination of the Liver, Gall Bladder and Bile Ducts.
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Utility of Serum Free Light Chain Measurements in Multiple Myeloma Patients Not Achieving Complete Response
Authors: Muhamad Alhaj Moustafa, S. Vincent Rajkumar, Angela Dispenzieri, Francis K Buadi, Morie A Gertz, Martha Q. Lacy, Prashant Kapoor, Suzanne R Hayman, David Dingli, Robert Kyle, Shaji Kumar
Journal: Blood (2014)
Abstract 006: Relationship of Sedentary Behavior and Physical Inactivity to Incident Coronary Heart Disease: Results from the Women's Health Initiative
Authors: Andrea K Chomistek, Bing Lu, Megan Sands, Scott B Going, Lorena Garcia, Matthew A Allison, Marcia L Stefanick, Stacy T Sims, Michael J LaMonte, Karen C Johnson, JoAnn E Manson, Charles B Eaton
Journal: Circulation (2012)

Background: Sedentary behavior, such as prolonged sitting, is becoming recognized as a distinct construct that may not merely reflect lack of leisure-time physical activity (PA), usually defined as physical inactivity. Our objective was to examine the independent and joint associations of sedentary time and physical inactivity with risk of incident coronary heart disease (CHD) in women. Methods: This study included 84,798 post-menopausal women, aged 50-79 and free of CHD at baseline, participating in the Women's Health Initiative Observational Study. At baseline, participants reported information on sedentary behavior, defined as hours of sitting and lying per day, and usual PA, defined as energy expenditure from recreational activity including walking, mild, moderate and strenuous PA. Participants were followed from the baseline visit through September 2010 for first occurrence of CHD (MI and CHD death). Cox regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for incident CHD according to tertiles of sedentary time (hrs/day) and physical activity (MET-hrs/wk). Results: Sedentary time ≥10 hrs/day was associated with increased CHD risk (HR=1.13, 95% CI 1.04,1.23) in age-adjusted models, but was non-significant in multivariable-adjusted models (HR=1.08, 95% CI 0.99,1.17). In multivariable-adjusted models, the HR of CHD comparing moderate (5.1 - 16.25 MET-hrs/wk) and low (≤ 5 MET-hrs/wk) levels of PA to high (&gt;16.25 MET-hrs/wk) levels were 1.10 (95%CI 1.01,1.21) and 1.21 (95%CI 1.11,1.32), respectively (P for trend &lt;.0001). When we cross-classified women by sedentary time and PA (P for interaction = 0.91), CHD risk was significantly increased only in women with low PA regardless of their sedentary behavior, with the greatest risk seen in women reporting low PA and ≥10 hrs/day of sedentary time. Conclusion: Physical inactivity is associated with increased CHD risk in a dose-response manner, whereas sedentary behavior was only modestly associated with CHD risk in this analysis. Physical Activity (MET-hours/week) Sedentary Time (hours/day) High (&gt; 16.25) Moderate (5.1 - 16.25) Low (≤ 5) ≤6 1.00 (Referent) 1.12 (0.96, 1.30) 1.17 (1.01, 1.36) 6.1-9.9 0.96 (0.82, 1.13) 1.09 (0.94, 1.27) 1.18 (1.02, 1.38) ≥10 1.08 (0.92, 1.27) 1.14 (0.99, 1.32) 1.32(1.15, 1.51) The multivariable model includes age, race, education, income, marital status, smoking, family history of MI, depression, alcohol intake, and history of diabetes, hypertension, or hypercholesterolemia
Current Therapeutic Research, New York
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Severity of underlying disease as a predictor of nosocomial infection. Utility in the control of nosocomial infection
Authors: M. R. Britt
Journal: JAMA (1978)

In a prospective study, we determined that severity of underlying disease at time of admission indicates medical patients at unusual risk of nosocomial infection. The nosocomial infection rate was 23.6% in patients with fatal underlying disease, 9.6% in those with ultimately fatal disease, and 2.1% in those with nonfatal disease. After an awareness program that promoted the use of established methods for prevention of nosocomial infections was established, there was a decline of overall incidence of endemic nosocomial infections from 9.2% to 4.8% (<i>P</i>&lt;.001) within an eight-month period. With subsequent discontinuation of the program, the infection rate rose to 8.1%. Reinstitution of the program resulted in a decline to 5.2% (<i>P</i>=.05). (<i>JAMA</i>239:1047-1051, 1978)
Detection and activation of HIV broadly neutralizing antibody precursor B cells using anti-idiotypes
Authors: Tara Bancroft, Blair L. DeBuysscher, Connor Weidle, Allison Schwartz, Abigail Wall, Matthew D. Gray, Junli Feng, Holly R. Steach, Kristin S. Fitzpatrick, Mesfin M. Gewe, Patrick D. Skog, Colleen Doyle-Cooper, Takayuki Ota, Roland K. Strong, David Nemazee, Marie Pancera, Leonidas Stamatatos, Andrew T. McGuire, Justin J. Taylor
Journal: The Journal of Experimental Medicine (2019)

Many tested vaccines fail to provide protection against disease despite the induction of antibodies that bind the pathogen of interest. In light of this, there is much interest in rationally designed subunit vaccines that direct the antibody response to protective epitopes. Here, we produced a panel of anti-idiotype antibodies able to specifically recognize the inferred germline version of the human immunodeficiency virus 1 (HIV-1) broadly neutralizing antibody b12 (iglb12). We determined the crystal structure of two anti-idiotypes in complex with iglb12 and used these anti-idiotypes to identify rare naive human B cells expressing B cell receptors with similarity to iglb12. Immunization with a multimerized version of this anti-idiotype induced the proliferation of transgenic murine B cells expressing the iglb12 heavy chain in vivo, despite the presence of deletion and anergy within this population. Together, our data indicate that anti-idiotypes are a valuable tool for the study and induction of potentially protective antibodies.
Jargon
Authors: Charles G. Roland
Journal: JAMA (1968)

In scientific writing, jargon comprises two major subdivisions. Although these may overlap and cause confusion, at their extremes they are easily distinguished. One subdivision is that of technical language; the other includes the pejorative or contemptuous connotations of jargon. That part of so-called jargon which we recognize as technical language is an acceptable and necessary part of scientific communication. Because of this I would suggest to the lexicographers that we stop using the word jargon to mean technical language, and limit "jargon" to its pejorative uses, many of which result from the abuse of technical language. Every profession and trade has its technical language, a private tongue intelligible only to initiates. Technical language serves a function which ordinary language cannot serve, or at least cannot serve without excessive wordiness. But a private language is jargon if it replaces ordinary language only to exclude persons not belonging to the clique who
Diffuse collagen disease
Authors: J. Churg
Journal: JAMA (1984)

<h3>To the Editor.—</h3> The March 23-30, 1984, issue ofThe Journalcarries the reprint of the article on diffuse collagen disease by Klemperer et al<sup>1</sup>originally published in<i>JAMA</i>in 1942 as well as a pertinent and pithy commentary by George E. Ehrlich.<sup>2</sup> It occurred to me that your readers may be interested in a bit of medical history as it pertains to the development of the concept of collagen diseases. Although new scientific insights sometimes appear to be the result of sudden inspiration, more often they are gained by hard work, testing of hypotheses, and following many leads before a valid idea emerges and is confirmed. I was privileged to serve at the Mount Sinai Hospital as a trainee and as a member of the staff during the period when Klemperer, Baehr, Schifrin, and Pollack were struggling to understand the nature of several mysterious disorders, among them