tbuckley/cabot-search huggingface dataset:
DANGEROUS WOOD ALCOHOL.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Booknotes
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A pilot study of rhuIL‐11 treatment of refractory ITP
Authors: James B. Bussel, Robin Mukherjee, Anne J. Stone
Journal: American Journal of Hematology (2001)

The objective of this research was to determine whether rhuIL-11 is an effective treatment in patients with refractory immune thrombocytopenic purpura (ITP). Platelet production is decreased in certain cases of refractory ITP. IL-11 stimulates megakaryocytopoiesis in vitro and was licensed for its clinical effects to ameliorate chemotherapy-induced thrombocytopenia. A pilot study was initiated, intending to enroll 12 patients with ITP. These patients were to receive rhuIL-11 (Neumega) at a dose of 50 μg/kg subcutaneously daily for 21 consecutive days and be observed afterward for 21 additional days. CBC with platelets were obtained twice weekly with visits and physical examinations weekly. The study was terminated after 7 patients were enrolled because of toxicity and lack of efficacy. All 7 patients had had ITP for >9 years and had failed splenectomy, intravenous gammaglobulin, corticosteroids, and a variety of other treatments. The patients at entry all had platelet counts <20,000/μl; 5 of 7 had counts <10,000/μl. The maximal median increase for any day of the study was 6,000/μl. No patient achieved a count of 30,000/μl, and only 3 patients achieved (once each) a platelet count >20,000/μl. Substantial toxicity was seen. The nadir hemoglobin decrease was a mean of 2 g/dl. rhuIL-11 was not effective at increasing the platelet count in any of these patients with refractory ITP. Toxicity was substantial. The lack of platelet response to rhuIL-11 in this study does not exclude the possibility of better effects at other doses and/or in less refractory patients. Am. J. Hematol. 66:172–177, 2001. © 2001 Wiley-Liss, Inc.
Closing the gaps in health insurance coverage. Council on Medical Service
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Midwifery Mechanics.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sauna-Takers Disease
Authors: W. James Metzger
Journal: JAMA (1976)

Daily saunas taken by a young man were followed by fever, chills, malaise, dyspnea, cough, and myalgia from six to eight hours later. Symptoms, which were related to pouring water from a sauna bucket over the heating element, progressed to chronic dyspnea and fatigue. Serial serum samples showed precipitin reactions to bucket water and extracts of bucket mold. IgG antibody activity, demonstrated by radioimmunoassay, suggested that<i>Pullularia</i>was a major antigen. (<i>JAMA</i>236:2209-2211, 1976)
Emotional impairment in internal medicine house staff
Authors: Gary Anderson
Journal: JAMA (1986)

<h3>To the Editor.—</h3> I found the article "Emotional Impairment in Internal Medicine House Staff"1 both interesting and disturbing. It has been nine months since my residency in family practice, which included five months of first-year medicine. I would like to make some observations based on my own experiences. I was very disturbed that only one third of the directors thought that the work load or working conditions might be a factor in emotional impairment. My feelings are that it is one of the major causes of impairment or "resident burnout." I performed my residency in an urban private medical center of about 500 beds. A typical on-call schedule is being on call every third day. The day started at 7 AM and would be over by 6 PM, if it was a quiet day and the resident was efficient. We were required to come in every Saturday for about four
LETTER FROM PARIS.
Authors: None A. B.
Journal: JAMA (1890)

(FROM OUR REGULAR CORRESPONDENT.) Atropine and Morphine to Combat the Noxious Effects of Chloroform—Interstitial Infections of Solution of the Bichloride of Mercury in the Treatment of Tumors—Treatment of Hæmorrhage due to Fibromata by preparations of Ergot of Rye and Hydrastis Canadensis. Dr. Dastre has, for some time, undertaken experiments with a view of combating in the dog the noxious effects of chloroform, by the association of atropine and of morphine, and Dr. Aubert, of Lyons, was the first to endeavor to ascertain on man the advantages of this method. In a note by Dr. Reynier on the subject, which he read at a recent meeting of the Société de Chirurgie, he stated that he has employed this method in a certain number of cases in his service at the Hospital Tenon, and he has had one death, which he believes should be attributed to the association of these three elements.
10. Microvascular Complications and Foot Care: <i>Standards of Medical Care in Diabetes—2018</i>
Journal: Diabetes Care (2017)

The American Diabetes Association (ADA) “Standards of Medical Care in Diabetes” includes ADA’s current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, a multidisciplinary expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA’s clinical practice recommendations, please refer to the Standards of Care Introduction. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
Comparable Hypolipemic Effects of Desiccated Thyroid in Negroes and Whites
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical schools in Canada
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OVERSUPPLY OF MEDICAL PRODUCTS.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lessons of the "pink spot".
Journal: BMJ (1967)

Lessons of the "Pink Spot"There is nothing like a snappy name for catching the public imagination.The demonstration of the " pink spot" in schizophrenia fired the enthusiasm of journalists, accountants, and scientists in other fields in a way the name dimethoxyphenylethylamine could never do.The spots which caused the excitement were not on the patients but on paper chromatograms of extracts from their urines, and became visible and coloured only after special staining.The very simplicity of the name conveyed (quite falsely) that the observations and interpretations were simple, in welcome contrast to the greater part of modern science.In fact this work was done in a biochemical-psychiatric borderland where very few people know enough to feel really at home.Few biochemists know much about psychiatry.Few psychiatrists feel other than extremely modest about their knowledge of biochemistry.Consequently each kind of specialist has his doubts about a new claim from the borderland, but feels not quite enough of an overall expert to express them.Nevertheless, the consensus of opinion at a recent meeting of psychiatrists at the Royal Society of Medicine was that the " pink spot" is now dead.It remains to say what went wrong and to see what is left.Human urine contains substances as the Milky Way has stars.They are many and various, a few obvious and striking; many are mere traces.Frequently special methods are needed for their isolation and identification.What is found in a urine specimen depends, therefore, on how much urine is tested, how fresh it is, how much the specimen can be concentrated, and how sensitive a test can be applied to the concentrate.It also depends on a large number of ordinary physiological variables-such as the degree of diuresis, alkalinity of the urine, time of day it was collected, and the diet of the patient.A. J. Friedhoff and E. van Winkle' took a 20-hour specimen of urine from 19 schizophrenic patients and 10 normal people.They made the urine alkaline to pH 9 and shook it with ethylene dichloride, which is a standard way of extracting basic substances of organic type from urine-such as tryptamine and other amines which are formed by the body, and many drugs and their metabolites.They concentrated this extract to a very small volume so that a single drop put on the starting line at one end of a paper strip represented about two hours' urine production.The drop was allowed to dry, and the paper strip held vertically and dipped into a butanol- acetic-acid-water mixture.This solvent rose slowly up in the paper to the top, drawing with it from the starting line at different speeds the different ingredients of the urine con- centrate.Thus the ingredients were dispersed vertically in line up the paper.When the paper was dry and stained with ninhydrin a number of them showed up as blue spots.After overstaining with Ehrlich's aldehyde reagent the blue spots faded, but a single pink spot often stood out about two-thirds the way up the paper.This pink spot was present in 15 schizophrenic patients, but in none of the normal people.
Reversal of Raynaud's phenomenon
Authors: R. P. Leavitt
Journal: JAMA (1979)

<h3>To the Editor.—</h3> It is a rare experience to find immediate clinical applicability of a technique reported in the latest issue of a medical journal. On Dec 15, 1978, having just read McIntyre's description of "A Maneuver To Reverse Raynaud's Phenomenon of the Fingers" (240:2760, 1978), I relayed specifics of his technique to a co-worker who has a long history of idiopathic Raynaud's phenomenon of the fingers, with attacks usually precipitated by exposure to cold and lasting 30 to 60 minutes. She is a commercial artist, needing continuous dexterity of her fingers, and has found immersion of fingers in warm water to provide unsatisfactorily inconvenient, unavailable, or slow relief. On the same day during which she was informed of McIntyre's recommendations, she had a Raynaud attack, apparently from hand contact with a cold steering wheel, and despite a delay of more than ten minutes, on arrival to a nonautomotive, private
UP-TO-DATE JOURNALS.
Journal: JAMA (1903)

There is an unfortunate practice—we do not know how far it is unavoidable—of certain medical journals appearing later than their advertised time and yet having nothing on their pages to show the exact date of appearance. We have in mind one otherwise excellent journal which habitually appears about three months late, the October number usually appearing in January, and so on through the year. This is, in one sense of the word, an imposition on its readers, and is more important when one comes to consult files of some years back. For instance, if a journal has an article giving an account of something new, some new discovery of importance, very serious questions of priority might arise, and unless the fact of the delayed appearance were generally known, injustice be done. An article published in a journal dated three months or even one month earlier than its actual appearance might
A Symposium on the Evaluation of Drug Toxicity.
Journal: Annals of Internal Medicine (1959)

REVIEWSbrain.The author has thus excluded the peripheral nervous system from the discussion and only barely mentions the spinal cord.For each of the three metals there is an historical note, a discussion of the clinical features of the various metabolic abnormalities or intoxications, and sections on clinical pathology, histopathology, and treatment.Copper metabolism receives the most detailed consideration and this chapter includes a valuable discussion of normal as well as abnormal copper metabolism.There is an almost complete list of published cases of hepato-lenticular degeneration.The chapter on mercury contains a section on pink disease.
Substantial immune response in Omicron infected breakthrough and unvaccinated individuals against SARS-CoV-2 variants of concern
Authors: Pragya D Yadav, Gajanan N Sapkal, Rima R Sahay, Varsha A Potdar, Gururaj R Deshpande, Deepak Y Patil, Dimpal A Nyayanit, Anita M Shete, Jayanthi Shastri, Pradip Awate, Bharti Malhotra, Priya Abraham
Journal: Journal of Infection (2022)
From the Food and Drug Administration
Authors: Stuart L. Nightingale
Journal: JAMA (1997)

<h3>Public Hearing on Benzodiazepine Scheduling Criteria:</h3> With participation from the National Institute on Drug Abuse and the Drug Enforcement Administration, the FDA will convene a hearing on the scheduling of benzodiazepines and benzodiazepine-related sub-stances. The purpose of this hearing, which will be held in Washington, DC, on September 11 and 12, 1997, is to gather evidence on possible ways to distinguish the abuse potential of different benzodiazepines, which will assist the federal government in scheduling reviews under the Controlled Substances Act. Benzodiazepines and related drug substances consistently rank among the most widely prescribed pharmaceuticals in the United States and are used extensively as anxiolytics, sedatives, muscle relaxants, and hypnotics. However, because of benzodiazepines' capacity to produce physical and psychological dependence, there are concerns over their misuse and the level of domestic and international control (scheduling) needed to prevent abuse. Recent studies suggest that it is possible to distinguish the pharmacological properties
Re: Veerle H. Groen, Karin Haustermans, Floris J. Pos, et al. Patterns of Failure Following External Beam Radiotherapy With or Without an Additional Focal Boost in the Randomized Controlled FLAME Trial for Localized Prostate Cancer. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2021.12.012
Authors: Kamal Kant Sahu
Journal: European Urology (2022)
Chemotherapeutic nanomaterials in tumor boundary delineation: Prospects for effective tumor treatment
Authors: Ozioma Udochukwu Akakuru, Zhoujing Zhang, M. Zubair Iqbal, Chengjie Zhu, Yewei Zhang, Aiguo Wu
Journal: Acta Pharmaceutica Sinica B (2022)

Accurately delineating tumor boundaries is key to predicting survival rates of cancer patients and assessing response of tumor microenvironment to various therapeutic techniques such as chemotherapy and radiotherapy. This review discusses various strategies that have been deployed to accurately delineate tumor boundaries with particular emphasis on the potential of chemotherapeutic nanomaterials in tumor boundary delineation. It also compiles the types of tumors that have been successfully delineated by currently available strategies. Finally, the challenges that still abound in accurate tumor boundary delineation are presented alongside possible perspective strategies to either ameliorate or solve the problems. It is expected that the information communicated herein will form the first compendious baseline information on tumor boundary delineation with chemotherapeutic nanomaterials and provide useful insights into future possible paths to advancing current available tumor boundary delineation approaches to achieve efficacious tumor therapy.