tbuckley/cabot-search huggingface dataset:
Hyaluronic acid and chondroitin sulfate (meth)acrylate-based hydrogels for tissue engineering: Synthesis, characteristics and pre-clinical evaluation
Authors: Carl.C.L. Schuurmans, Marko Mihajlovic, Christine Hiemstra, Keita Ito, Wim E. Hennink, Tina Vermonden
Journal: Biomaterials (2020)

Hydrogels based on photocrosslinkable Hyaluronic Acid Methacrylate (HAMA) and Chondroitin Sulfate Methacrylate (CSMA) are presently under investigation for tissue engineering applications. HAMA and CSMA gels offer tunable characteristics such as tailorable mechanical properties, swelling characteristics, and enzymatic degradability. This review gives an overview of the scientific literature published regarding the pre-clinical development of covalently crosslinked hydrogels that (partially) are based on HAMA and/or CSMA. Throughout the review, recommendations for the next steps in clinical translation of hydrogels based on HAMA or CSMA are made and potential pitfalls are defined. Specifically, a myriad of different synthetic routes to obtain polymerizable hyaluronic acid and chondroitin sulfate derivatives are described. The effects of important parameters such as degree of (meth)acrylation and molecular weight of the synthesized polymers on the formed hydrogels are discussed and useful analytical techniques for their characterization are summarized. Furthermore, the characteristics of the formed hydrogels including their enzymatic degradability are discussed. Finally, a summary of several recent applications of these hydrogels in applied fields such as cartilage and cardiac regeneration and advanced tissue modelling is presented.
Is COVID-19–Induced Platelet Activation a Cause of Concern for Patients with Cancer?
Authors: Lenard M. Lichtenberger, K. Vinod Vijayan
Journal: Cancer Research (2020)

Abstract Patients with cancer are more susceptible to be infected by SARS-CoV-2 and develop severe outcomes including ICU admittance, mechanical ventilator support, and a high rate of mortality. Like mid-to late-stage cancer, SARS-CoV-2 infection is associated with platelet hyperactivity, systemic inflammation, thrombotic complications, and coagulopathy. Platelets also promote cancer cell growth, survival in circulation, and angiogenesis at sites of metastases. In this article, we will discuss the potential for platelets in the development of systemic inflammation and thrombosis in SARS-CoV-2–infected patients with cancer, with the concern that the platelet-induced pathogenic events are likely magnified in cancer patients with COVID-19.
Cancer Cell Fitness Is Dynamic
Authors: Luana S. Lenz, Juliano L. Faccioni, Paula A. Bracco, Jephesson A.F. Santos, Luiza C. Pereira, Julieti H. Buss, Mauricio T. Tamborindeguy, Daphne Torgo, Thayana Monteiro, Giovana B. Mantovani, Carolina N. Santo, Julia C. Marcolin, Eloisa Dalsin, Alvaro Vigo, Sidia M. Callegari-Jacques, Andrew O. Silva, Giovana R. Onzi, Karine R. Begnini, Guido Lenz
Journal: Cancer Research (2020)

Several phenotypes that impact the capacity of cancer cells to survive and proliferate are dynamic. Here we used the number of cells in colonies as an assessment of fitness and devised a novel method called Dynamic Fitness Analysis (DynaFit) to measure the dynamics in fitness over the course of colony formation. DynaFit is based on the variance in growth rate of a population of founder cells compared with the variance in growth rate of colonies with different sizes. DynaFit revealed that cell fitness in cancer cell lines, primary cancer cells, and fibroblasts under unhindered growth conditions is dynamic. Key cellular mechanisms such as ERK signaling and cell-cycle synchronization differed significantly among cells in colonies after 2 to 4 generations and became indistinguishable from randomly sampled cells regarding these features. In the presence of cytotoxic agents, colonies reduced their variance in growth rate when compared with their founder cell, indicating a dynamic nature in the capacity to survive and proliferate in the presence of a drug. This finding was supported by measurable differences in DNA damage and induction of senescence among cells of colonies. The presence of epigenetic modulators during the formation of colonies stabilized their fitness for at least four generations. Collectively, these results support the understanding that cancer cell fitness is dynamic and its modulation is a fundamental aspect to be considered in comprehending cancer cell biology and its response to therapeutic interventions. SIGNIFICANCE: Cancer cell fitness is dynamic over the course of the formation of colonies. This dynamic behavior is mediated by asymmetric mitosis, ERK activity, cell-cycle duration, and DNA repair capacity in the absence or presence of a drug.
Upregulation of HLA-F expression by BK polyomavirus infection induces immune recognition by KIR3DS1-positive natural killer cells
Authors: Tobias F. Koyro, Emma Kraus, Sebastian Lunemann, Angelique Hölzemer, Sonia Wulf, Johannes Jung, Pia Fittje, Florian Henseling, Christian Körner, Tobias B. Huber, Adam Grundhoff, Thorsten Wiech, Ulf Panzer, Nicole Fischer, Marcus Altfeld
Journal: Kidney International (2020)
Acute Coronary Syndrome With Anterior Precordial ST Depression
Authors: Aayush K. Singal, Bharath Raj Kidambi, Raghav Bansal
Journal: JAMA Internal Medicine (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Effect of Motor Skill Training in Functional Activities vs Strength and Flexibility Exercise on Function in People With Chronic Low Back Pain
Authors: Linda R. van Dillen, Vanessa M. Lanier, Karen Steger-May, Michael Wallendorf, Barbara J. Norton, Jesse M. Civello, Sylvia L. Czuppon, Sara J. Francois, Kristen Roles, Catherine E. Lang
Journal: JAMA Neurology (2020)

Chronic low back pain (LBP) is the most prevalent chronic pain in adults, and there is no optimal nonpharmacologic management. Exercise is recommended, but no specific exercise-based treatment has been found to be most effective.
Thiolated polymeric hydrogels for biomedical application: Cross-linking mechanisms
Authors: Simona Summonte, Giuseppe Francesco Racaniello, Angela Lopedota, Nunzio Denora, Andreas Bernkop-Schnürch
Journal: Journal of Controlled Release (2020)

This review focuses on the synthesis of hydrogel networks using thiomers such as thiolated hyaluronic acid, chitosan, cyclodextrin, poly(ethylene glycol) and dextran that are cross-linked via their thiol substructures. Thiomers have been widely investigated as matrix of hydrogels due to the high reactivity of these sulfhydryl moieties. They are well known for their in situ gelling properties due to the formation of inter- and intra-chain disulfide bonds. Furthermore, as thiol groups on the polymeric backbone of thiomers cannot only react with each other but also with different other functional groups, several "click" methods such as thiol-ene/yne, Michael type addition and thiol-epoxy reactions have been developed within the last decades to fabricate thiomer hydrogels. These hydrogels are meanwhile used as scaffolds for tissue engineering, regenerative medicine, diagnostics and as matrix for drug and protein delivery.
Pancreatic perforation and fistula caused by pancreatic spontaneous dislodgement stent: an endoscopic rescue technique
Authors: Hiroshi Kawakami, Hiroshi Hatada, Yoshimasa Kubota, Souichiro Ogawa, Hotaka Tamura, Naoki Yoshida, Naomi Uchiyama
Journal: Endoscopy (2020)

Pancreatic stenting is widely used to prevent pancreatitis occurring after endoscopic retrograde cholangiopancreatography (ERCP) [1]. In general, a pancreatic spontaneous dislodgement stent (PSDS) with a duodenal pigtail prevents intraductal migration. Serious adverse events after PSDS placement, such as migration into the portal vein, have been reported [2]. Here, we present a case of pancreatic perforation and fistula caused by a dislocated and migrated PSDS and the technique by which rescue was achieved.
Predicting Outcome After Implantable Cardioverter-Defibrillator Therapy: A New Piece to the Puzzle?⁎⁎Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Authors: Richard K. Shepard, Kenneth A. Ellenbogen
Journal: Journal of the American College of Cardiology (2009)
Abstract 18738: Using 3D Printing With Virtual Surgery to Identify Residual Transverse Arch Obstruction in Coarctation Correction
Authors: Kevin K Whitehead, Kevin A Gralewski, Yoav Dori
Journal: Circulation (2016)

Introduction: Transverse arch (tArch) hypoplasia often accompanies coarctation of the aorta (CoA), causing residual arch obstruction after repair. We propose a novel technique for surgical planning...
Newly prescribed canagliflozin vs. GLP-1 agonists was linked to amputation in older adults with type 2 DM and CVD
Authors: Qiukui Hao, Gordon Guyatt
Journal: Annals of Internal Medicine (2021)

Source Citation Fralick M, Kim SC, Schneeweiss S, et al. Risk of amputation with canagliflozin across categories of age and cardiovascular risk in three US nationwide databases: cohort study. BMJ. 2020;370:m2812. 32843476
Autologous Stem Cell Transplantation in the Management of Relapsed Non-Hodgkin Lymphoma
Authors: Alvaro J. Alencar, Craig H. Moskowitz
Journal: Journal of Clinical Oncology (2021)

Article Tools REVIEW ARTICLES Immunotherapy for Hematologic Malignancies Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.20.01751 Journal of Clinical Oncology - published online before print January 12, 2021 PMID: 33434059 Autologous Stem Cell Transplantation in the Management of Relapsed Non-Hodgkin Lymphoma Alvaro J. Alencar , MD1xAlvaro J. AlencarSearch for articles by this author and Craig H. Moskowitz, MD1xCraig H. MoskowitzSearch for articles by this author Show More 1Division of Hematology, Department of Medicine, University of Miami Sylvester Comprehensive Cancer Center, Miami, FL https://doi.org/10.1200/JCO.20.01751 First Page Full Text PDF Figures and Tables © 2021 by American Society of Clinical OncologyContextKey ObjectiveIs chimeric antigen receptor (CAR) T-cell therapy replacing autologous stem cell transplantation (ASCT) in the management of patients with relapsed diffuse large B-cell lymphoma (DLBCL)?Knowledge GeneratedCAR T-cell therapy has impressive activity, but failures are common, and logistic challenges still limit its use. ASCT remains a curative intervention in patients with chemosensitive disease, particularly those with complete metabolic response after salvage.RelevanceThe future of management of relapsed DLBCL lies in accurate patient selection and better integration of novel techniques with well-established therapeutic options.AUTHOR CONTRIBUTIONSConception and design: All authorsCollection and assembly of data: All authorsData analysis and interpretation: All authorsFinal approval of manuscript: All authorsAccountable for all aspects of the work: All authorsAUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTERESTAutologous Stem Cell Transplantation in the Management of Relapsed Non-Hodgkin LymphomaThe following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated unless otherwise noted. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/jco/authors/author-center.Open Payments is a public database containing information reported by companies about payments made to US-licensed physicians (Open Payments).Alvaro J. AlencarConsulting or Advisory Role: Celgene, AbbVie/Genentech, Kite Pharma, Spectrum Pharmaceuticals, Amgen, Karyopharm TherapeuticsSpeakers’ Bureau: Kite Pharma (I)Research Funding: Loxo (Inst)Open Payments Link: https://openpaymentsdata.cms.gov/physician/1171980Craig H. MoskowitzConsulting or Advisory Role: Merck Sharp & Dohme, Molecular Templates, Takeda, AstraZeneca, IncyteResearch Funding: AstraZeneca (Inst), Merck Sharp & Dohme (Inst)No other potential conflicts of interest were reported.
AB0040 The influence of the war conditions on the treatment course of rheumathoid arthritis
Authors: N Kapidzic-Basic, H Seleskovic, S Kikanovic, S Mulic
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> Complicated therapy of the rheumatoid arthritis does not always give satisfying results so there is an opinion that the disease progresses with or without the treatment. During the war in Bosnia and Herzegovina (BiH) neither diagnostic nor therapy were possible and difficulties went on after the war. Humanitarian aid brought only certain amount of medications from the NSAIDs group, and DMRADs were used rarely. <h3>Objectives</h3> The aim of this work was to determine the severity of the change on locomotion system of RA patients who did not take DMARDs therapy during the war and to determine functional disability of those patients. <h3>Methods</h3> Examination was conducted on 100 RA patients (according to modified ACR criteria) who had no therapy, but occasional NSAIDs during the 6 year period, nor physical therapy. Control group was 40 RA patients who lived outside of BiH during the war and who had taken DMARDs and physical therapy. Both groups were comparable with the length of the disease. The activity of the disease was evaluated (ESR, CRP, morning stiffness, visual analogue scale of pain, Ritchie index of joints sensitivity) as well as functional state index measured by HAQ, range of motion (ROM) and radiological examination. Only one part of this large study will be presented here. <h3>Results</h3> Mean duration of the disease was 12,1 years (SD 8,3). According to HAQ three groups were made: mild disability 0–1 (11% of patients), moderate 1,01–2.0 (40% of patients) and severe 2,01–3 (49%). 4% of patients had no movement. HAQ results of the control group were following: 67,5% of patients were in the I group, 30% patients were in the II group and 2,5% of patients were in the III group. In the study of Wolfe <i>et al</i>.<sup>1</sup> 43,25% patients were in the I group, 42,5% of patients were in the II group and 14,5% of patients were in the III group. And all other parameters were worse than the ones in the control group. <h3>Conclusion</h3> It is obvious that disease strongly progresses without the usage of the drugs and physical therapy. More than half of the patients in the examined group were dependable on other people's help. Problems with the therapy of RA patients do not end with the end of the war because inhabitance became poor and the RA therapy is very expensive for the most patients. <h3>Reference</h3> Wolfe F, Kleinheksel SM, Cathey MA, Hawley D, Spitz P, Fries J. The clinical value of the stanford health assessment questionnaire functional disability index in patients with rheumatoid arthritis. J Rheumatol. 1988;15:10
Current Selection of Optimal Prosthetic Aortic Valve Replacement in Middle-Aged Patients: Still Dealer's Choice⁎⁎Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Authors: Peter H. Stone
Journal: Journal of the American College of Cardiology (2009)
Assessment of hepatic steatosis by controlled attenuation parameter using the M and XL probes: an individual patient data meta-analysis
Authors: David Petroff, Valentin Blank, Philip N Newsome, None Shalimar, Cosmin Sebastian Voican, Maja Thiele, Victor de Lédinghen, Stephan Baumeler, Wah Kheong Chan, Gabriel Perlemuter, Ana-Carolina Cardoso, Sandeep Aggarwal, Magali Sasso, Peter J Eddowes, Michael Allison, Emmanuel Tsochatzis, Quentin M Anstee, David Sheridan, Jeremy F Cobbold, Sylvie Naveau, Monica Lupsor-Platon, Sebastian Mueller, Aleksander Krag, Marie Irles-Depe, David Semela, Grace Lai-Hung Wong, Vincent Wai-Sun Wong, Cristiane A Villela-Nogueira, Harshit Garg, Olivier Chazouillères, Johannes Wiegand, Thomas Karlas
Journal: The Lancet. Gastroenterology & hepatology (2021)
Development and Validation of a Risk Tool for Predicting Severe Toxicity in Older Adults Receiving Chemotherapy for Early-Stage Breast Cancer
Authors: Allison Magnuson, Mina S. Sedrak, Cary P. Gross, William P. Tew, Heidi D. Klepin, Tanya M. Wildes, Hyman B. Muss, Efrat Dotan, Rachel A. Freedman, Tracey O'Connor, William Dale, Harvey J. Cohen, Vani Katheria, Anait Arsenyan, Abrahm Levi, Heeyoung Kim, Supriya Mohile, Arti Hurria, Can-Lan Sun
Journal: Journal of Clinical Oncology (2021)

Limited tools exist to predict the risk of chemotherapy toxicity in older adults with early-stage breast cancer.Patients of age ≥ 65 years with stage I-III breast cancer from 16 institutions treated with neoadjuvant or adjuvant chemotherapy were prospectively evaluated for geriatric and clinical features predictive of grade 3-5 chemotherapy toxicity. Logistic regression with best-subsets selection was used to identify and incorporate independent predictors of toxicity into a model with weighted variable scoring. Model performance was evaluated using area under the ROC curve (AUC) and goodness-of-fit statistics. The model was internally and externally validated.In 473 patients (283 in development and 190 in validation cohort), 46% developed grade 3-5 chemotherapy toxicities. Eight independent predictors were identified (each assigned weighted points): anthracycline use (1 point), stage II or III (3 points), planned treatment duration > 3 months (4 points), abnormal liver function (3 points), low hemoglobin (3 points), falls (4 points), limited walking (3 points), and lack of social support (3 points). We calculated risk scores for each patient and defined three risk groups: low (0-5 points), intermediate (6-11 points), or high (≥ 12 points). In the development cohort, the rates of grade 3-5 chemotherapy toxicity for these three groups were 19%, 54%, and 87%, respectively (P < .01). In the validation cohort, the corresponding toxicity rates were 27%, 45%, and 76%. The AUC was 0.75 (95% CI, 0.70 to 0.81) in the development cohort and 0.69 (95% CI, 0.62 to 0.77) in the validation cohort. Risk groups were also associated with hospitalizations and reduced dose intensity (P < .01).The Cancer and Aging Research Group-Breast Cancer (CARG-BC) score was developed and validated to predict grade 3-5 chemotherapy toxicity in older adults with early-stage breast cancer.
The intratumoral CXCR3 chemokine system is predictive of chemotherapy response in human bladder cancer
Authors: Tino Vollmer, Stephan Schlickeiser, Leila Amini, Sarah Schulenberg, Desiree J. Wendering, Viqar Banday, Anke Jurisch, Rebecca Noster, Desiree Kunkel, Nicola R. Brindle, Ioannis Savidis, Levent Akyüz, Jochen Hecht, Ulrik Stervbo, Toralf Roch, Nina Babel, Petra Reinke, Ola Winqvist, Amir Sherif, Hans-Dieter Volk, Michael Schmueck-Henneresse
Journal: Science Translational Medicine (2021)

Activity of the CXCR3alt-CXCL11 chemokine system in CD8 + stem-like T cells predicts chemotherapy response in patients with bladder cancer.
Abstract 15571: Echocardiographic Characteristics and Their Association With Outcome in Hospitalized Covid-19 Patients With Cardiovascular Disease
Authors: Yuman Li, Lingyun Fang, Shuangshuang Zhu, Yuji Xie, Bin Wang, He Lin, Danqing Zhang, Yongxing Zhang, Hongliang Yuan, Chun Wu, Wei Sun, yanting zhang, Meng Li, Yu Cai, Li Cui, Jing Wang, Yali Yang, Lv Qing, Li Zhang, Mingxing XIE
Journal: Circulation (2020)

Background: Echocardiographic characteristics and the prognostic value of echocardiographic parameters in COVID-19 patients with cardiovascular disease (CVD) remain unclear. Objectives: We aimedto describe and compare echocardiographic characteristics of hospitalized COVID-19 patients with and without CVD, and explore the prognostic value of echocardiographic parameters in COVID-19 patients with CVD. Methods: 157 consecutive hospitalized COVID-19 patients were enrolled in our study. Left ventricular (LV) and right ventricular (RV) structure and function were assessed using bedside echocardiography. Results: 89 (56.7 %) patients had underlying CVD.Compared with patients without CVD, those with CVD were more likely to havehigher levels of high-sensitivity troponin I (hs-TNI) and B-type natriuretic peptide, and higher incidence of ARDS, acute heart injury and deep vein thrombosis. During hospitalization, 23(14.6%) patients died. Mortality was significantly higher in CVD compared with non-CVD patients (22.5% vs. 4.4%, p =0.002). CVD patients had increased mitral E/e’, lower tricuspid annular plane systolic excursion (TAPSE) and RV fractional area change (RVFAC), and higher pulmonary artery systolic pressure. TAPSE, RVFAC and elevated hs-TNI level were independent predictors of higher mortality.Furthermore, we found the incremental prognostic value of TAPSE over RVFAC and clinical parameters in COVID-19 patients with CVD using a likelihood ratio test, Akaike information criterion and C-index. Conclusions: COVID-19 patients with CVD displayed impaired cardiac function, which is associated with higher mortality. The additional prognostic value of TAPSE over the other clinical and echocardiographic parameters indicate that TAPSE measurement may be important for risk stratification in COVID-19 patients with CVD.
Sparing a little may save a lot: Lessons from the Studies of Left Ventricular Dysfunction (SOLVD)**Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Authors: Adrian F Hernandez, Christopher M O'Connor
Journal: Journal of the American College of Cardiology (2003)
The Role of B7 Costimulation by Murine Acute Myeloid Leukemia in the Generation and Function of a CD8+ T-Cell Line With Potent In Vivo Graft-Versus-Leukemia Properties
Authors: Michael W. Boyer, Daniel A. Vallera, Patricia A. Taylor, Gary S. Gray, Emmanuel Katsanis, Keith Gorden, Paul J. Orchard, Bruce R. Blazar
Journal: Blood (1997)