COVID-19: Colorectal cancer endoscopic surveillance in IBD
Authors: Shahida Din, Daniel R Gaya, Ian D R Arnott
Journal: The Lancet. Gastroenterology & hepatology (2021)

We commend the Article by Alexander Ho and colleagues1Ho KMA Banerjee A Lawler M Rutter MD Lovat LB Predicting endoscopic activity recovery in England after COVID-19: a national analysis.Lancet Gastroenterol Hepatol. 2021; 6: 381-390Summary Full Text Full Text PDF PubMed Scopus (39) Google Scholar detailing the backlog of endoscopic procedures in England during the COVID-19 pandemic. Several strategies are proposed to manage this backlog including high-level triage, use of quantitative faecal immunochemical test (qFIT), and alternatives to endoscopy such as radiological imaging and colon capsule. Ho and colleagues'1Ho KMA Banerjee A Lawler M Rutter MD Lovat LB Predicting endoscopic activity recovery in England after COVID-19: a national analysis.Lancet Gastroenterol Hepatol. 2021; 6: 381-390Summary Full Text Full Text PDF PubMed Scopus (39) Google Scholar data suggest that surveillance procedures—eg, for high-risk populations such as those with inflammatory bowel disease—have been slower to recover. This trend could have been compounded by the tools mentioned being less applicable in inflammatory bowel disease. For instance, qFIT detects degraded human haemoglobin and is used relatively infrequently in inflammatory bowel disease. A qFIT of more than 100 ng/mL (equivalent to >20 μg/g) is associated with a Mayo endoscopic subscore of more than 1, suggesting that qFIT can detect active colonic inflammation.2Nakarai A Kato J Hiraoka S et al.Evaluation of mucosal healing of ulcerative colitis by a quantitative fecal immunochemical test.Am J Gastroenterol. 2013; 108: 83-89Crossref PubMed Scopus (86) Google Scholar In the UK, a higher qFIT score at greater than 10 μg/g (in symptomatic cohorts) and more than 80 μg/g (bowel cancer screening population)3Clark G Strachan JA Carey FA et al.Transition to quantitative faecal immunochemical testing from guaiac faecal occult blood testing in a fully rolled-out population-based national bowel screening programme.Gut. 2021; 70: 106-113Crossref PubMed Scopus (29) Google Scholar is likely to detect colonic inflammation, confounding its use as a risk stratification tool in inflammatory bowel disease surveillance. Furthermore, CT colonography and colon capsule are unlikely to be useful alternatives when screening for flat dysplasia or subtle mucosal abnormalities. Before the COVID-19 pandemic, the rates of post-colonoscopy colorectal cancer in inflammatory bowel disease were unacceptably high.4Burr NE Derbyshire E Taylor J et al.Variation in post-colonoscopy colorectal cancer across colonoscopy providers in English National Health Service: population based cohort study.BMJ. 2019; 367l6090Crossref PubMed Scopus (92) Google Scholar The absence of a suitable alternative to endoscopic surveillance and the high demand on endoscopy capacity could result in delayed cancer diagnoses. Non-invasive stool testing for DNA methylation markers has shown promising results5Kisiel JB Klepp P Allawi HT et al.Analysis of DNA methylation at specific loci in stool samples detects colorectal cancer and high-grade dysplasia in patients with inflammatory bowel disease.Clin Gastroenterol Hepatol. 2019; 17: 914-921Summary Full Text Full Text PDF PubMed Scopus (36) Google Scholar and once validated could prioritise patients awaiting surveillance procedures. It is crucial to use available endoscopic resources effectively. Currently, there is no clear exit strategy for patients with inflammatory bowel disease at low risk of developing colorectal cancer, who undergo surveillance colonoscopy at 5 yearly intervals. In a study of 775 patients with colonic inflammatory bowel disease (excluding those in the highest risk category), Ten Hove and colleagues6Ten Hove JR Shah SC Shaffer SR et al.Consecutive negative findings on colonoscopy during surveillance predict a low risk of advanced neoplasia in patients with inflammatory bowel disease with long-standing colitis: results of a 15-year multicentre, multinational cohort study.Gut. 2019; 68: 615-622Crossref PubMed Scopus (24) Google Scholar that two consecutive negative colonoscopies predicted a low risk of future colorectal cancer. The median interval between the colonoscopies was 2·2 years and the longest follow-up from first surveillance was 6·1 years.6Ten Hove JR Shah SC Shaffer SR et al.Consecutive negative findings on colonoscopy during surveillance predict a low risk of advanced neoplasia in patients with inflammatory bowel disease with long-standing colitis: results of a 15-year multicentre, multinational cohort study.Gut. 2019; 68: 615-622Crossref PubMed Scopus (24) Google Scholar Surveillance intervals are likely to be longer in the UK and, for patients perpetually in the low risk 5-year interval, stopping surveillance might be a valid strategy, although longer term data is needed. Cessation of surveillance requires appropriate safety-netting; however, this approach could help to mitigate the overall burden on endoscopy services. There are currently no good alternatives to endoscopic surveillance for colorectal cancer in inflammatory bowel disease and the restarting of surveillance procedures is an urgent priority for health-care providers. This online publication has been corrected. The corrected version first appeared at thelancet.com/gastrohep on December 9, 2021 This online publication has been corrected. The corrected version first appeared at thelancet.com/gastrohep on December 9, 2021 SD has received payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing, or educational events from Takeda and Dr Falk, and has SD received support for attending meetings or travel from AbbVie, Takeda, Dr Falk, and Janssen. IDRA has received payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Takeda, Vifor, and Dr Falk. DRG declares no competing interests. Predicting endoscopic activity recovery in England after COVID-19: a national analysisOur work highlights the impact of the pandemic on endoscopy services nationally. Even with mitigation measures, it could take much longer than a year to eliminate the pandemic-related backlog. Urgent action is required by key stakeholders (ie, individual NHS trusts, Clinical Commissioning Groups, British Society of Gastroenterology, and NHS England) to tackle the backlog and prevent delays to patient management. Full-Text PDF Correction to Lancet Gastroenterol Hepatol 2021; 6: 526–27Din S, Gaya DR, Arnott IDR. COVID-19: colorectal cancer endoscopic surveillance in IBD. Lancet Gastroenterol Hepatol 2021; 6: 526–27—In this Correspondence, the fourth and fifth lines of the second paragraph should read "A qFIT of more than 100 ng/mL (equivalent to >20 μg/g) is associated with a Mayo endoscopic subscore of more than 1, suggesting that qFIT can detect active colonic inflammation.2 In the UK, a qFIT score greater than 10 μg/g (in symptomatic cohorts) and more than 80 μg/g (bowel cancer screening population)3 is likely to detect colonic inflammation, confounding its use as a risk stratification tool in inflammatory bowel disease surveillance." This correction has been made online as of Dec 9, 2021. Full-Text PDF