tbuckley/cabot-search huggingface dataset:
Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways
Authors: Xiang Wang, Xinxin Chen, Wenqian Zhou, Hongbo Men, Terigen Bao, Yike Sun, Quanwei Wang, Yi Tan, Bradley B. Keller, Qian Tong, Yang Zheng, Lu Cai
Journal: Acta Pharmaceutica Sinica B (2021)

Herein, we define the role of ferroptosis in the pathogenesis of diabetic cardiomyopathy (DCM) by examining the expression of key regulators of ferroptosis in mice with DCM and a new ex vivo DCM model. Advanced glycation end-products (AGEs), an important pathogenic factor of DCM, were found to induce ferroptosis in engineered cardiac tissues (ECTs), as reflected through increased levels of Ptgs2 and lipid peroxides and decreased ferritin and SLC7A11 levels. Typical morphological changes of ferroptosis in cardiomyocytes were observed using transmission electron microscopy. Inhibition of ferroptosis with ferrostatin-1 and deferoxamine prevented AGE-induced ECT remodeling and dysfunction. Ferroptosis was also evidenced in the heart of type 2 diabetic mice with DCM. Inhibition of ferroptosis by liproxstatin-1 prevented the development of diastolic dysfunction at 3 months after the onset of diabetes. Nuclear factor erythroid 2-related factor 2 (NRF2) activated by sulforaphane inhibited cardiac cell ferroptosis in both AGE-treated ECTs and hearts of DCM mice by upregulating ferritin and SLC7A11 levels. The protective effect of sulforaphane on ferroptosis was AMP-activated protein kinase (AMPK)-dependent. These findings suggest that ferroptosis plays an essential role in the pathogenesis of DCM; sulforaphane prevents ferroptosis and associated pathogenesis via AMPK-mediated NRF2 activation. This suggests a feasible therapeutic approach with sulforaphane to clinically prevent ferroptosis and DCM.
Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma
Authors: Jennifer S. Stevens, Nathaniel G. Harnett, Lauren A.M. Lebois, Sanne J.H. van Rooij, Timothy D. Ely, Alyssa Roeckner, Nico Vincent, Francesca L. Beaudoin, Xinming An, Donglin Zeng, Thomas C. Neylan, Gari D. Clifford, Sarah D. Linnstaedt, Laura T. Germine, Scott L. Rauch, Christopher Lewandowski, Alan B. Storrow, Phyllis L. Hendry, Sophia Sheikh, Paul I. Musey, John P. Haran, Christopher W. Jones, Brittany E. Punches, Michael S. Lyons, Michael C. Kurz, Meghan E. McGrath, Jose L. Pascual, Elizabeth M. Datner, Anna M. Chang, Claire Pearson, David A. Peak, Robert M. Domeier, Brian J. O’Neil, Niels K. Rathlev, Leon D. Sanchez, Robert H. Pietrzak, Jutta Joormann, Deanna M. Barch, Diego A. Pizzagalli, John F. Sheridan, Beatriz Luna, Steven E. Harte, James M. Elliott, Vishnu P. Murty, Tanja Jovanovic, Steven E. Bruce, Stacey L. House, Ronald C. Kessler, Karestan C. Koenen, Samuel A. McLean, Kerry J. Ressler
Journal: American Journal of Psychiatry (2021)

Major negative life events, such as trauma exposure, can play a key role in igniting or exacerbating psychopathology. However, few disorders are diagnosed with respect to precipitating events, and the role of these events in the unfolding of new psychopathology is not well understood. The authors conducted a multisite transdiagnostic longitudinal study of trauma exposure and related mental health outcomes to identify neurobiological predictors of risk, resilience, and different symptom presentations.
Continuous Glucose Monitoring Use and Access Disparities—Reply
Authors: Andrew J. Karter, Lisa K. Gilliam, Richard Dlott
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OA19.03 Differences in Detection Patterns, Characteristics, and Outcomes of Central and Peripheral Lung Cancers in Low-Dose CT Screening
Authors: Y.W. Kim, M. Jeon, M.J. Song, B.S. Kwon, S.Y. Lim, Y.J. Lee, J.S. Park, Y. Cho, H.I. Yoon, K.W. Lee, J.H. Lee, C. Lee
Journal: Journal of Thoracic Oncology (2021)
A High-Content Screen for C/EBPα Expression Identifies Novel Therapeutic Agents in Dedifferentiated Liposarcoma
Authors: Christina V. Angeles, Ana Velez, Jordan Rios, Bernadette Laxa, David Shum, Penelope D. Ruiz, Yawei Shen, Irina Ostrovnaya, Rodrigo Gularte-Mérida, Benjamin A. Nacev, Mark A. Dickson, Hakim Djaballah, Tomoyo Okada, Samuel Singer
Journal: Clinical Cancer Research (2021)

Abstract Purpose: Dedifferentiated liposarcoma (DDLS), one of the most common and aggressive sarcomas, infrequently responds to chemotherapy. DDLS survival and growth depend on underexpression of C/EBPα, a tumor suppressor and transcriptional regulator controlling adipogenesis. We sought to screen and prioritize candidate drugs that increase C/EBPα expression and may therefore serve as differentiation-based therapies for DDLS. Experimental Design: We screened known bioactive compounds for the ability to restore C/EBPα expression and inhibit proliferation selectively in two DDLS cell lines but not in normal adipose-derived stem cells (ASC). Selected hits' activity was validated, and the mechanism of the most potent, SN-38, was investigated. The in vivo efficacy of irinotecan, the prodrug of SN-38, was evaluated in DDLS xenograft models. Results: Of 3,119 compounds, screen criteria were met by 19. Validation experiments confirmed the DDLS selectivity of deguelin, emetine, and SN-38 and showed that they induce apoptosis in DDLS cells. SN-38 had the lowest IC50 (approximately 10 nmol/L), and its pro-apoptotic effects were countered by knockdown of CEBPA but not of TP53. Irinotecan significantly inhibited tumor growth at well-tolerated doses, induced nuclear expression of C/EBPα, and inhibited HIF1α expression in DDLS patient-derived and cancer cell line xenograft models. In contrast, doxorubicin, the most common treatment for nonresectable DDLS, reduced tumor growth by 30% to 50% at a dose that caused weight loss. Conclusions: This high-content screen revealed potential treatments for DDLS. These include irinotecan, which induces apoptosis of DDLS cells in a C/EBPα-dependent, p53-independent manner, and should be clinically evaluated in patients with advanced DDLS.
Prodrug nanoparticles rationally integrating stroma modification and chemotherapy to treat metastatic pancreatic cancer
Authors: Liying Wang, Zimo Liu, Quan Zhou, Sufang Gu, Xiangsheng Liu, Jianxiang Huang, Haiping Jiang, Huifang Wang, Liping Cao, Jihong Sun, Youqing Shen, Huan Meng, Xiangrui Liu
Journal: Biomaterials (2021)
FP09.01 Mobocertinib in Platinum-Pretreated EGFR Exon 20 Insertion+ Metastatic NSCLC Patients With/Without Prior Anti-PD(L)-1 Therapy
Authors: P. Janne, S. Ramalingam, T. Kim, J.C. Yang, G. Riely, T. Mekhail, D. Nguyen, M.R. García Campelo, E. Felip, S. Jin, C. Griffin, V. Bunn, J. Lin, M. Mehta, C. Zhou
Journal: Journal of Thoracic Oncology (2021)
P03.02 Osimertinib as Neoadjuvant Therapy for Resectable EGFR Mutant Non-small Cell Lung Cancer: A Real-World Multicenter Retrospective Study
Authors: X. Leng, J. Tang, S. Wang, Y. Wang, P. Li, S. Wang, X. Wei, L. Peng, Q. Fang, Y. Han
Journal: Journal of Thoracic Oncology (2021)
Self-assembling protein nanocarrier for selective delivery of cytotoxic polypeptides to CXCR4+ head and neck squamous cell carcinoma tumors
Authors: Elisa Rioja-Blanco, Irene Arroyo-Solera, Patricia Álamo, Isolda Casanova, Alberto Gallardo, Ugutz Unzueta, Naroa Serna, Laura Sánchez-García, Miquel Quer, Antonio Villaverde, Esther Vázquez, Ramon Mangues, Lorena Alba-Castellón, Xavier León
Journal: Acta Pharmaceutica Sinica B (2021)

Loco-regional recurrences and distant metastases represent the main cause of head and neck squamous cell carcinoma (HNSCC) mortality. The overexpression of chemokine receptor 4 (CXCR4) in HNSCC primary tumors associates with higher risk of developing loco-regional recurrences and distant metastases, thus making CXCR4 an ideal entry pathway for targeted drug delivery. In this context, our group has generated the self-assembling protein nanocarrier T22-GFP-H6, displaying multiple T22 peptidic ligands that specifically target CXCR4. This study aimed to validate T22-GFP-H6 as a suitable nanocarrier to selectively deliver cytotoxic agents to CXCR4+ tumors in a HNSCC model. Here we demonstrate that T22-GFP-H6 selectively internalizes in CXCR4+ HNSCC cells, achieving a high accumulation in CXCR4+ tumors in vivo, while showing negligible nanocarrier distribution in non-tumor bearing organs. Moreover, this T22-empowered nanocarrier can incorporate bacterial toxin domains to generate therapeutic nanotoxins that induce cell death in CXCR4-overexpressing tumors in the absence of histological alterations in normal organs. Altogether, these results show the potential use of this T22-empowered nanocarrier platform to incorporate polypeptidic domains of choice to selectively eliminate CXCR4+ cells in HNSCC. Remarkably, to our knowledge, this is the first study testing targeted protein-only nanoparticles in this cancer type, which may represent a novel treatment approach for HNSCC patients.
PL02.03 Lurbinectedin/Doxorubicin versus CAV or Topotecan in Relapsed SCLC Patients: Phase III Randomized ATLANTIS Trial
Authors: L. Paz-Ares, T. Ciuleanu, A. Navarro, A. Fulop, S. Cousin, L. Bonanno, E. Smit, A. Chiappori, M.E. Olmedo, I. Horvath, C. Grohé, J.A. Lopez-Vilariño, R. Nuñez, A. Nieto, M. Cullell, N. Vasco, C. Kahatt, A. Zeaiter, E. Carcereny, J. Roubec, K. Syrigos, G. Lo, I. Barneto
Journal: Journal of Thoracic Oncology (2021)
Enhanced cancer therapeutic efficiency of NO combined with siRNA by caspase-3 responsive polymers
Authors: Yi Yan, Cheng-Han Wang, Shi-He Cui, Lin Zhai, Jing Sun, Xiao-Yu Liu, Xin Chen, Yi Sun, Hong-Gang Qian, Xiang Gao, Yi-Da Tang, Yuan-Jun Zhu, Yu-Jie Shi, Qiang Zhang, Jian-Cheng Wang
Journal: Journal of Controlled Release (2021)
Prediabetes Defined by First Measured HbA1c Predicts Higher Cardiovascular Risk Compared With HbA1c in the Diabetes Range: A Cohort Study of Nationwide Registries
Authors: Sam Kafai Yahyavi, Ole Snorgaard, Filip Krag Knop, Morten Schou, Christina Lee, Christian Selmer, Gunnar Gislason, Christian Torp-Pedersen, Martin Blomberg Jensen, Anders Nissen Bonde
Journal: Diabetes Care (2021)

To assess the risk of major adverse cardiovascular events (MACE), all-cause mortality, and initiation of medical treatment in subjects with prediabetes according to first-time measured HbA1c.Through registry databases, we identified 326,305 Danish patients with a first HbA1c between 40 and 51 mmol/mol (5.8-6.8%) from 2011 to 2017. After exclusion of patients with prior disease, 84,678 patients were followed 12 months after first HbA1c measurement. Cox regression models were used to estimate hazard ratios (HRs) of MACE and standardized absolute risks. Cumulative incidences were used to analyze initiation of glucose-lowering, antihypertensive, cholesterol-lowering, and antithrombotic medication.The 12-month risk of MACE and all-cause mortality increased gradually with increasing HbA1c until 47 mmol/mol (6.5%). In comparisons of subjects with HbA1c 40-41 mmol/mol (5.8-5.9%), subjects with HbA1c 46-47 mmol/mol (6.4-6.5%) had a 0.79% (95% CI 0.33-1.24) higher standardized absolute risk and an HR of 2.21 (95% CI 1.67-2.92) of MACE. Patients with HbA1c 48-49 mmol/mol (6.5-6.6%) had a 0.09% (95% CI -0.35 to 0.52) lower absolute risk and an HR of 1.33 (95% CI 0.87-2.05) of MACE. Initiation of medication was significantly lower among patients with HbA1c of 46-47 mmol/mol (6.4-6.5%) than among patients with HbA1c of 48-49 mmol/mol (6.5-6.6%).In the Danish population screened for diabetes with HbA1c, the highest risk of MACE and all-cause mortality was found in subjects with HbA1c just below the diagnostic threshold for diabetes. Our results highlight the need for increased focus on the treatment of cardiovascular risk factors for subjects with prediabetes.
P53.04 Local Therapies vs. Specific TKIs as the Initial Treatment for Oligo-Recurrent Lung Adenocarcinoma With Driver Mutations
Authors: Y. Matsuura, H. Ninomiya, K. Hashimoto, J. Ichinose, M. Nakao, S. Okumura, M. Nishio, M. Mun
Journal: Journal of Thoracic Oncology (2021)
Construction of a niche-specific spinal white matter-like tissue to promote directional axon regeneration and myelination for rat spinal cord injury repair
Authors: Bi-Qin Lai, Yu-Rong Bai, Wei-Tao Han, Bao Zhang, Shu Liu, Jia-Hui Sun, Jia-Lin Liu, Ge Li, Xiang Zeng, Ying Ding, Yuan-Huan Ma, Ling Zhang, Zheng-Hong Chen, Jun Wang, Yuan Xiong, Jin-Hua Wu, Qi Quan, Ling-Yan Xing, Hong-Bo Zhang, Yuan-Shan Zeng
Journal: Bioactive Materials (2021)

Directional axon regeneration and remyelination are crucial for repair of spinal cord injury (SCI), but existing treatments do not effectively promote those processes. Here, we propose a strategy for construction of niche-specific spinal white matter-like tissue (WMLT) using decellularized optic nerve (DON) loaded with neurotrophin-3 (NT-3)-overexpressing oligodendrocyte precursor cells. A rat model with a white matter defect in the dorsal spinal cord of the T10 segment was used. The WMLT transplantation group showed significant improvement in coordinated motor functions compared with the control groups. WMLT transplants integrated well with host spinal cord white matter, effectively addressing several barriers to directional axonal regeneration and myelination during SCI repair. In WMLT, laminin was found to promote development of oligodendroglial lineage (OL) cells by binding to laminin receptors. Interestingly, laminin could also guide linear axon regeneration via interactions with specific integrins on the axon surface. The WMLT developed here utilizes the unique microstructure and bioactive matrix of DON to create a niche rich in laminin, NT-3 and OL cells to achieve significant structural repair of SCI. Our protocol can help to promote research on repair of nerve injury and construction of neural tissues and organoids that form specific cell niches.
Covid-19: Is New Zealand’s switch in policy a step forward or a retreat?
Authors: Owen Dyer
Journal: BMJ (2021)

Covid-19: Is New Zealand's switch in policy a step forward or a retreat?The country's zero tolerance approach to the pandemic was both unique and popular.Owen Dyer asks what comes next and what lessons have been learntOwen Dyer "For this outbreak, it's clear that long periods of heavy restrictions have not got us to zero cases," said New Zealand's prime minister, Jacinda Ardern, announcing on 4 October that the country was shifting from a policy of elimination to a mitigation approach more in line with policies in other developed countries."But that is okay.Elimination was important because we didn't have vaccines.Now we do, so we can begin to change the way we do things."Changes on the ground are minimal, for now.In Auckland, the only region under lockdown, groups of up to 10 are now permitted to assemble outside, and early childhood education has resumed.But it is the first time that New Zealand has relaxed restrictions without first suppressing new cases.
Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity
Authors: Giusy Di Conza, Chin-Hsien Tsai, Hector Gallart-Ayala, Yi-Ru Yu, Fabien Franco, Lea Zaffalon, Xin Xie, Xiaoyun Li, Zhengtao Xiao, Lydia N. Raines, Maryline Falquet, Antoine Jalil, Jason W. Locasale, Piergiorgio Percipalle, David Masson, Stanley Ching-Cheng Huang, Fabio Martinon, Julijana Ivanisevic, Ping-Chih Ho
Journal: Nature Immunology (2021)
IL-1-driven stromal–neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies
Authors: Matthias Friedrich, Mathilde Pohin, Matthew A. Jackson, Ilya Korsunsky, Samuel J. Bullers, Kevin Rue-Albrecht, Zoe Christoforidou, Dharshan Sathananthan, Tom Thomas, Rahul Ravindran, Ruchi Tandon, Raphael Sanches Peres, Hannah Sharpe, Kevin Wei, Gerald F. M. Watts, Elizabeth H. Mann, Alessandra Geremia, Moustafa Attar, Francesca Barone, Michael Brenner, Christopher D. Buckley, Mark Coles, Andreas P. Frei, Kara G. Lassen, Fiona M. Powrie, Sarah McCuaig, Lloyd Thomas, Elena Collantes, Holm H. Uhlig, Stephen N. Sansom, Alistair Easton, Soumya Raychaudhuri, Simon P. Travis, Fiona M. Powrie
Journal: Nature Medicine (2021)

Abstract Current inflammatory bowel disease (IBD) therapies are ineffective in a high proportion of patients. Combining bulk and single-cell transcriptomics, quantitative histopathology and in situ localization across three cohorts of patients with IBD (total n = 376), we identify coexpressed gene modules within the heterogeneous tissular inflammatory response in IBD that map to distinct histopathological and cellular features (pathotypes). One of these pathotypes is defined by high neutrophil infiltration, activation of fibroblasts and vascular remodeling at sites of deep ulceration. Activated fibroblasts in the ulcer bed display neutrophil-chemoattractant properties that are IL-1R, but not TNF, dependent. Pathotype-associated neutrophil and fibroblast signatures are increased in nonresponders to several therapies across four independent cohorts (total n = 343). The identification of distinct, localized, tissular pathotypes will aid precision targeting of current therapeutics and provides a biological rationale for IL-1 signaling blockade in ulcerating disease.
Serum Carboxypeptidase Activity and Genotype-Stratified CA19-9 to Detect Early-Stage Pancreatic Cancer
Authors: Haruyoshi Tanaka, Koji Tamura, Toshiya Abe, Takeichi Yoshida, Anne Macgregor-Das, Mohamad Dbouk, Amanda L Blackford, Michael Borges, Anne Marie Lennon, Jin He, Richard Burkhart, Marcia Irene Canto, Michael Goggins
Journal: Clinical Gastroenterology and Hepatology (2021)
Associations between HIV infection and clinical spectrum of COVID-19: a population level analysis based on US National COVID Cohort Collaborative (N3C) data
Authors: Xueying Yang, Jing Sun, Rena C Patel, Jiajia Zhang, Siyuan Guo, Qulu Zheng, Amy L Olex, Bankole Olatosi, Sharon B Weissman, Jessica Y Islam, Christopher G Chute, Melissa Haendel, Gregory D Kirk, Xiaoming Li, Richard Moffitt, Hana Akelsrod, Keith A Crandall, Nora Francheschini, Evan French, Teresa Po-Yu Chiang, G Caleb-Alexander, Kathleen M Andersen, Amanda J Vinson, Todd T Brown, Roslyn B Mannon
Journal: The Lancet HIV (2021)
拡張型心筋症患者におけるQGSによるTime to Maximum Thickening(TTMT)の診断能
Authors: Matsumoto Naoya, Suzuki Yasuyuki, Masuoka Keiko, Iida Jun, Igarashi Yayoi, Yoda Shunichi, Nagao Ken, Hirayama Atsushi, Satoh Yuichi
Journal: Circulation (2013)
P52.05 Dual RAF/MEK Inhibitor VS-6766 for Treatment of KRAS Mutant NSCLC: Novel Combinations Targeting G12C or G12V Variants
Authors: S. Coma, S. Chowdhury, M. Musteanu, A. Stewart, L. Pickard, M. Krebs, A. Minchom, U. Banerji, M. Barbacid, J. Pachter
Journal: Journal of Thoracic Oncology (2021)
3D Liver Tissue Model with Branched Vascular Networks by Multimaterial Bioprinting
Authors: Xin Liu, Xinhuan Wang, Liming Zhang, Lulu Sun, Heran Wang, Hao Zhao, Zhengtao Zhang, Wenli Liu, Yiming Huang, Shen Ji, Jingjinqiu Zhang, Kai Li, Biaobiao Song, Chun Li, Hui Zhang, Song Li, Shu Wang, Xiongfei Zheng, Qi Gu
Journal: Advanced Healthcare Materials (2021)

Abstract Complicated vessels pervade almost all body tissues and influence the pathophysiology of the human body significantly. However, current fabrication strategies have limited success at multiscale vascular biofabrication. This study reports a methodology to fabricate soft vascularized tissue at centimeter scale using multimaterial bioprinting by a customized multistage‐temperature‐control printer. The printed constructs can be perfused via the branched endothelialized vasculatures to support the well‐formed 3D capillary networks, which ensure cellular activities with sufficient nutrient supply and then mimic a mature and functional liver tissue in terms of synthesis of liver‐specific proteins. Moreover, an inner and external pressure‐bearing layer is printed to support the direct surgical anastomosis of the carotid artery to the jugular vein. In summary, a versatile platform to recapitulate the vasculature network is presented, in which case sustaining the optimal cellularization in engineered tissues is achievable.
Consequences of Selling a Kidney in India
Authors: Amitabh Chandra
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
P23.02 Digital Multiplexed circRNA Analysis From Plasma-Derived Extracellular Vesicles of Lung Cancer Patients
Authors: C. Pedraz-Valdunciel, M. Filipska, S. Giannoukakos, N. Potie, A. Fernandez-Hilario, M. Hackenberg, A. Aguilar-Hernández, J. Valarezo, C. Huang, A. Giménez Capitán, C. Aguado Esteban, S. Warren, M.A. Molina-Vila, R. Rosell
Journal: Journal of Thoracic Oncology (2021)
What is the most important thing in the world?
Authors: Hamish Robert Osborne
Journal: British Journal of Sports Medicine (2021)

> He tangata, he tangata, he tangata
> 
> It is the people, it is the people, it is the people

Welcome to the Australasian College of Sport and Exercise Physicians (ACSEP) edition of BJSM . He tangata—it is the people in our lives that are important to us. How our two countries have managed the pandemic affecting the lives of the people around us will be told in stories for generations. Many more stories that affect our people are unfolding in front of us—not the least of which includes the warmest winter on record in Aotearoa New Zealand.

There are 68 people who have authored articles in this edition of BJSM ! It would be …