tbuckley/cabot-search huggingface dataset:
SARS-CoV-2 Receptor Networks in Diabetic Kidney Disease, BK Virus Nephropathy, and COVID-19 Associated AKI
Authors: Rajasree Menon, Edgar A. Otto, Rachel S. Sealfon, Viji Nair, Aaron Wong, Chandra L. Theesfeld, Xi Chen, Yuan Wang, Jennifer A. Schaub, Celine C. Berthier, Sean Eddy, Chrysta C. Lienczewski, Brad A. Godfrey, Ryann Sohaney, Helen C. Looker, Laura H. Mariani, Abhijit S. Naik, Robert G. Nelson, Olga Troyanskaya, Matthias Kretzler
Journal: Journal of the American Society of Nephrology (2020)

Background: Since the emergence of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), most of the focus has been on the respiratory failure caused by the resulting disease, COVID-19  However, the effects of COVID-19 in the kidney are increasingly recognized  Acute kidney injury (AKI) has been identified with varying prevalence around the world with higher rates (37-46%) reported in the USA  It is debatable whether AKI is an indirect consequence of systemic inflammation or a consequence of viral renal cell infection and tropism  We hypothesize that SARSCoV- 2 directly infects kidney tissue and increases the risk of developing AKI, worsening prognosis of COVID-19 patients  Methods: We studied 88 COVID-19 patients admitted to the Henry Ford Hospital, Detroit after April 15, 2020  Demographics were: mean age 60, 71% African American, 55% male  We quantified viral copies by RT-PCR (S and N genes) in urine sediments from 52 PCR-confirmed COVID-19 patients  We performed immunofluorescence for Membrane and Spike viral proteins in two COVID-19 biopsies  Results: The prevalence of AKI was 72%, with 32% of patients admitted to the ICU  The overall mortality rate was 14%, with no deaths in non-AKI patients  Viral proteins M and S were detected in the glomerulus, parietal cells and tubules of COVID-19 patients  In some tubules, positive SARS-CoV-2 overlapped with ACE2, the receptor for viral entry  Virus was detected in 61% of urine sediments, with 6-fold greater viral load in AKIpatient urines (copies/ng RNA: AKI, 7422±1338 vs No-AKI: 1523 ± 404;p<0 05, n=52)  The highest viral loads were detected three weeks post-AKI at 11,374±2248 copies/ng RNA (p<0 01)  Among COVID-19 AKI-patients who died, the urine viral load exceeded 8000 copies/ng RNA  Above this threshold, the mortality rate was 55%  Conclusions: Our data support that direct viral renal cell infection occurs in COVID-19 AKI patients with urinary viral genome detection  Greater urinary viral loads portend increased mortality  Urinary viral detection can facilitate management and treatment of COVID-19 and improve outcomes  Future research should focus on studying whether urine contains infective virus or sheds non-infective genomic fragments
JunD protects against chronic kidney disease by regulating paracrine mitogens
Authors: Evangéline Pillebout, Jonathan B. Weitzman, Martine Burtin, Carla Martino, Pierre Federici, Moshe Yaniv, Gérard Friedlander, Fabiola Terzi
Journal: Journal of Clinical Investigation (2003)

The AP-1 transcription factor, composed of Jun and Fos proteins, plays a crucial role in the fine tuning of cell proliferation. We showed previously that AP-1 complexes are activated during the proliferative response that parallels the development of renal lesions after nephron reduction, but little is known about the specific role of individual Jun/Fos components in the deterioration process. Here we used JunD knockout (JunD–/–) mice and an experimental model of chronic renal injury (75% nephron reduction) to explore the role of JunD. Nephron reduction resulted in an initial compensatory growth phase that did not require JunD. JunD, however, was essential to inhibit a second wave of cell proliferation and to halt the development of severe glomerular sclerosis, tubular dilation, and interstitial fibrosis. We show that the effects of junD inactivation are not cell autonomous and involve upregulation of the paracrine mitogen, TGF-α. Expression of a transgene (REM) encoding a dominant negative isoform of the EGFR, the receptor for TGF-α, prevented the second wave of cell proliferation and the development of renal lesions in bitransgenic JunD–/–/REM mice. We propose that JunD is part of a regulatory network that controls proliferation to prevent pathological progression in chronic renal diseases.
FGF8 induces epithelial-mesenchymal transition and promotes metastasis in oral squamous cell carcinoma
Authors: Yilong Hao, Yanxuan Xiao, Xiaoyu Liao, Shuya Tang, Xiaoyan Xie, Rui Liu, Qianming Chen
Journal: International Journal of Oral Science (2021)

Oral squamous cell carcinoma (OSCC) is one of the most common cancers worldwide, and with 354 864 new cases each year. Cancer metastasis, recurrence, and drug resistance are the main causes to cripples and deaths of OSCC patients. As potent growth factors, fibroblast growth factors (FGFs) are frequently susceptible to being hijacked by cancer cells. In this study, we show that FGF8 is upregulated in OSCC tissues and high FGF8 expression is related with a set of clinicopathologic parameters, including age, drinking, and survival time. FGF8 treatment enhances the invasive capability of OSCC cells. Lentivirus-based FGF8 expression promotes OSCC metastasis in a mouse lung metastasis model. Further, mechanistic study demonstrates that FGF8 induces epithelial-mesenchymal transition (EMT) in OSCC cells. These results highlight a pro-metastatic function of FGF8, and underscore the role of FGF8 in OSCC development.
The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens
Authors: Johnathan Canton, Hanna Blees, Conor M. Henry, Michael D. Buck, Oliver Schulz, Neil C. Rogers, Eleanor Childs, Santiago Zelenay, Hefin Rhys, Marie-Charlotte Domart, Lucy Collinson, Andres Alloatti, Cara J. Ellison, Sebastian Amigorena, Venizelos Papayannopoulos, David C. Thomas, Felix Randow, Caetano Reis e Sousa
Journal: Nature Immunology (2020)
Single-session endoscopic ultrasound-directed transgastric ERCP and percutaneous endoscopic gastrostomy (EDGE-PEG)
Authors: Zain A. Sobani, Swathi Paleti, Tarun Rustagi
Journal: Endoscopy (2020)

A 72-year-old man with a history of dementia, decompensated heart failure, and Roux-en-Y gastric bypass (RYGB) for obesity 30 years previously was admitted with obstructive jaundice. He also had failure to thrive, with poor oral intake and severe protein calorie malnutrition requiring enteral nutrition via a nasogastric tube.
Covid-19: What have we learnt about the new variant in the UK?
Authors: Elisabeth Mahase
Journal: BMJ (2020)

The new SARS-CoV-2 variant has evoked scenes reminiscent of the early days of covid-19 when much of the world banned travel to and from Wuhan, China. With large parts of south-east England locked down, <b>Elisabeth Mahase</b> looks at what we know so far
Geo-social gradients in predicted COVID-19 prevalence in Great Britain: results from 1 960 242 users of the COVID-19 Symptoms Study app
Authors: Ruth C E Bowyer, Thomas Varsavsky, Ellen J Thompson, Carole H Sudre, Benjamin A K Murray, Maxim B Freidin, Darioush Yarand, Sajaysurya Ganesh, Joan Capdevila, Elco Bakker, M Jorge Cardoso, Richard Davies, Jonathan Wolf, Tim D Spector, Sebastien Ourselin, Claire J Steves, Cristina Menni
Journal: Thorax (2020)

Understanding the geographical distribution of COVID-19 through the general population is key to the provision of adequate healthcare services. Using self-reported data from 1 960 242 unique users in Great Britain (GB) of the
Retinal Detachment after Treatment of Retinopathy of Prematurity with Laser versus Intravitreal Anti–Vascular Endothelial Growth Factor
Authors: Gerard P. Barry, Yinxi Yu, Gui-Shuang Ying, Lauren A. Tomlinson, Juliann Lajoie, Marilyn Fisher, Gil Binenbaum
Journal: Ophthalmology (2020)
Is acute heart failure a distinctive disorder? An analysis from <scp>BIOSTAT‐CHF</scp>
Authors: Beth A. Davison, Stefanie Senger, Iziah E. Sama, Gary G. Koch, Alexandre Mebazaa, Kenneth Dickstein, Nilesh J. Samani, Marco Metra, Stefan D. Anker, John G. Cleland, Leong L. Ng, Ify R. Mordi, Faiez Zannad, Gerasimos S. Filippatos, Hans L. Hillege, Piotr Ponikowski, Dirk J. van Veldhuisen, Chim C. Lang, Peter van der Meer, Julio Núñez, Antoni Bayés‐Genís, Christopher Edwards, Adriaan A. Voors, Gad Cotter
Journal: European Journal of Heart Failure (2020)
Milieu Intérieur: The Search for Myocardial Arteriogenic Signals⁎⁎Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Authors: Ronald W. Millard, Yigang Wang
Journal: Journal of the American College of Cardiology (2009)
The estrogen receptor, MTA3, Snail pathway in breast cancer
Authors: Paul A. Wade, Naoyuki Fujita, Masahiro Kajita
Journal: Cancer Research (2005)

SY19-2  Estrogen receptor alpha is a key determinant of breast cancer cell phenotype. Many of the biological effects of ER are mediated by the biological actions of direct target genes. We have identified a genetic pathway in breast cancer cells that regulates cell phenotype. MTA3 is a cell-type specific subunit of the Mi-2/NuRD transcriptional co-repressor complex. Expression of MTA3 is directly regulated by ER-α and SP1 transcription factors. The MTA3-containing version of the Mi-2/NuRD complex participates in transcriptional repression at target loci, thus providing estrogen-dependent repression of specific genes. One critical target of repression by MTA3 is the transcription factor Snail. Repression of Snail by MTA3 occurs at the level of histone and chromatin modification. The MTA3 containing Mi-2/NuRD complex is localized on the Snail promoter. Its action leads to the assembly of a locally repressive chromatin architecture. Snail is also a transcriptional repressor, its actions promote epithelial to mesenchymal transitions. The phenotypic alterations promoted by Snail are mediated by repression of specific genes, including components of tight junctions critical for epithelial cells. Surprisingly, Snail also directly represses transcription of ER-α. Snail-dependent repression of the ESR1 locus is mediated through local changes in chromatin. Snail binds to conserved sequence elements located in the first exon of ESR1, resulting in the recruitment of chromatin modification enzymes. These enzymes alter the modification state of core histones over the core promoter, leading to assembly of locally repressive chromatin. Thus, the ER-MTA3-Snail regulatory network provides an example of regulation of cell phenotype and invasive growth properties in brreast cancer cells through local alterations in histone modification and chromatin architecture.
Efficacy of Donor Lymphocyte Infusion in CD34+ Selected Allogeneic Hematopoietic Stem Cell Transplant for Myeloid and Lymphoid Malignancies: A Single Center Experience
Authors: Adam Bryant, Sean M. Devlin, H.R. Castro-Malaspina, Ann A. Jakubowski, Molly Maloy, Esperanza B. Papadopoulos, Sergio A. Giralt, Miguel-Angel Perales
Journal: Blood (2017)
Biological drug and drug delivery-mediated immunotherapy
Authors: Qingqing Xiao, Xiaotong Li, Yi Li, Zhenfeng Wu, Chenjie Xu, Zhongjian Chen, Wei He
Journal: Acta Pharmaceutica Sinica B (2020)

The initiation and development of major inflammatory diseases, i.e., cancer, vascular inflammation, and some autoimmune diseases are closely linked to the immune system. Biologics-based immunotherapy is exerting a critical role against these diseases, whereas the usage of the immunomodulators is always limited by various factors such as susceptibility to digestion by enzymes in vivo, poor penetration across biological barriers, and rapid clearance by the reticuloendothelial system. Drug delivery strategies are potent to promote their delivery. Herein, we reviewed the potential targets for immunotherapy against the major inflammatory diseases, discussed the biologics and drug delivery systems involved in the immunotherapy, particularly highlighted the approved therapy tactics, and finally offer perspectives in this field.
Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site
Authors: Shuo Chen, Jia-Le Wu, Ying Liang, Yi-Gang Tang, Hua-Xin Song, Li-Li Wu, Yang-Fei Xing, Ni Yan, Yun-Tong Li, Zheng-Yuan Wang, Shu-Jun Xiao, Xin Lu, Sai-Juan Chen, Min Lu
Journal: Cancer Cell (2020)
Bringing Ophthalmic Graduate Medical Education into the 2020s with Information Technology
Authors: Emily Cole, Nita G. Valikodath, April Maa, R.V. Paul Chan, Michael F. Chiang, Aaron Y. Lee, Daniel C. Tu, Thomas S. Hwang, Aaron Lee, Thomas S. Hwang, April Maa, Suzann Pershing, James Brandt, Nikolas London, Kelly Chung, Jessica Peterson
Journal: Ophthalmology (2020)
Incidence of COVID-19 Disease in Pediatric Kidney Transplant Recipients: A Report of the Improving Renal Outcomes Collaborative
Authors: Charles D. Varnell, Samhar I. Al-Akash, Craig W. Belsha, Abanti Chaudhuri, Rachel M. Engen, Paul Fadakar, Rouba Garro, Caroline A. Gluck, Jens W. Goebel, Jason Misurac, Corina Nailescu, Hiren P. Patel, Cozumel S. Pruette, Nancy M. Rodig, Jodi M. Smith, Judith S. VanSickle, Patricia L. Weng, Lara Danziger-Isakov, David K. Hooper, Michael E. Seifert
Journal: Journal of the American Society of Nephrology (2020)

Background: COVID-19 has been associated with increased morbidity in kidney transplant recipients  We aimed to identify risk factors for mortality in hospitalized kidney transplant recipients with COVID-19 Methods: We retrospectively reviewed the medical records of 75 kidney transplant recipients admitted for COVID-19 at our institution  Results: Among the 75 patients, 28 (37%) died at a median 8 days (range, 1-36) after admission to the hospital  The Table summarizes the demographics and initial labs values of both groups  Most of our patients were Hispanic (54%) and African American (32%) and 97% had hypertension and 65% had diabetes mellitus  There was no difference between the two groups in terms of sex, type of transplant, time from transplant, immunosuppressive medications, medical comorbidities, presenting symptoms, temperature, or pulse oximetry values on admission  Non-survivors were older and had higher BMI  On admission most patients were lymphopenic, had low CD3/CD4/CD8 counts and had higher inflammatory markers (ferritin, d-dimer, CRP, procalcitonin, interleukine-6 levels)  Non-survivors had statistically significant higher procalcitonin, IL-6 and pro-BNP levels on admission  More non-survivors required ICU stay (64% vs  13%, p < 0 001), intubation (57% vs  11%, p < 0,001) and renal replacement therapy (32% vs  17%, p=0 17) compared to survivors  There was no difference in secondary bacterial infections, CMV viremia, DVT or stroke between the two groups  In a multivariate analysis, BMI (OR 1 15, CI 1 04-1 30, p= 0 017 per unit increase), higher procalcitonin (OR 4 16, 1 09-18 87, p=0 046) and proBNP levels (OR 1 017, 1 002-1 034, p=0 039, per 100 unit increase) on admission were associated with increased mortality  Conclusions: COVID-19 is associated with increased mortality (37%) in our kidney transplant recipients and higher BMI, procalcitonin and proBNP levels at admission are associated with mortality
Protein Intake and Cause-Specific Mortality—Reply
Authors: Jiaqi Huang, Demetrius Albanes
Journal: JAMA Internal Medicine (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
“The Guts to Really Look at It”—Medicine and Race in Robert Colescott’s <i>Emergency Room</i>
Authors: Kamna S. Balhara, Nathan Irvin
Journal: JAMA (2020)

This Arts and Medicine feature describes the use of the painting Emergency Room, by Robert Colescott, to broach uncomfortable discussions with emergency medicine trainees and faculty about organized medicine’s contribution to racial injustice and inequity, past and present.
Ambulatory management of secondary spontaneous pneumothorax: a randomised controlled trial
Authors: Steven P. Walker, Emma Keenan, Oliver Bintcliffe, Andrew E. Stanton, Mark Roberts, Justin Pepperell, Ian Fairbairn, Edward McKeown, James Goldring, Nadeem Maddekar, James Walters, Alex West, Amrithraj Bhatta, Matthew Knight, Rachel Mercer, Rob Hallifax, Paul White, Robert F. Miller, Najib M. Rahman, Nick A. Maskell
Journal: European Respiratory Journal (2020)

Secondary spontaneous pneumothorax (SSP) is traditionally managed with an intercostal chest tube attached to an underwater seal. We investigated whether use of a one-way flutter valve shortened patients’ length of stay (LoS). This open-label randomised controlled trial enrolled patients presenting with SSP and randomised to either a chest tube and underwater seal (standard care: SC) or ambulatory care (AC) with a flutter valve. The type of flutter valve used depended on whether at randomisation the patient already had a chest tube in place: in those without a chest tube a pleural vent (PV) was used; in those with a chest tube in situ , an Atrium Pneumostat (AP) valve was attached. The primary end-point was LoS. Between March 2017 and March 2020, 41 patients underwent randomisation: 20 to SC and 21 to AC (13=PV, 8=AP). There was no difference in LoS in the first 30 days following treatment intervention: AC (median=6 days, IQR 14.5) and SC (median=6 days, IQR 13.3). In patients treated with PV there was a high rate of early treatment failure (6/13; 46%), compared to patients receiving SC (3/20; 15%) (p=0.11) Patients treated with AP had no (0/8 0%) early treatment failures and a median LoS of 1.5 days (IQR 23.8). There was no difference in LoS between ambulatory and standard care. Pleural Vents had high rates of treatment failure and should not be used in SSP. Atrium Pneumostats are a safer alternative, with a trend towards lower LoS.
Two Decades Since <i>To Err Is Human</i>
Authors: Victor J. Dzau, Kenneth I. Shine
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Association of Lipid Mediators With Development of Future Incident Inflammatory Arthritis in an Anti–Citrullinated Protein Antibody–Positive Population
Authors: Kristen J. Polinski, Elizabeth A. Bemis, Fan Yang, Tessa Crume, M. Kristen Demoruelle, Marie Feser, Jennifer Seifert, James R. O’Dell, Ted R. Mikuls, Michael H. Weisman, Peter K. Gregersen, Richard M. Keating, Jane Buckner, Nichole Reisdorph, Kevin D. Deane, Michael Clare‐Salzler, V. Michael Holers, Jill M. Norris
Journal: Arthritis & Rheumatology (2020)

To determine the association of polyunsaturated fatty acid (PUFA)-derived lipid mediators with progression from rheumatoid arthritis (RA)-related autoimmunity to inflammatory arthritis (IA).We conducted a prospective cohort study using data from the Studies of the Etiology of Rheumatoid Arthritis (SERA). SERA enrolled first-degree relatives (FDRs) of individuals with RA (FDR cohort) and individuals who screened positive for RA-related autoantibodies at health fairs (screened cohort). We followed up 133 anti-cyclic citrullinated peptide 3.1 (anti-CCP3.1)-positive participants, 29 of whom developed IA. Lipid mediators selected a priori were quantified from stored plasma samples using liquid chromatography tandem mass spectrometry. We fit multivariable Cox proportional hazards models for each lipid mediator as a time-varying variable. For lipid mediators found to be significantly associated with IA, we then examined interleukin-1β (IL-1β), IL-6, IL-8, and tumor necrosis factor (TNF) as potential statistical mediators.For every 1 natural log pg/ml increase in the circulating plasma levels of proinflammatory 5-HETE, the risk of developing IA increased by 241% (hazard ratio 2.41 [95% confidence interval 1.43-4.07]) after adjusting for age at baseline, cohort (FDR or screened), and shared epitope status. The models examining 15-HETE and 17-HDHA had the same trend but did not reach significance. We did not find evidence that the association between 5-HETE and IA risk was influenced by the proinflammatory cytokines tested.In a prospective cohort of anti-CCP-positive individuals, higher levels of 5-HETE, an important precursor to proinflammatory leukotrienes, is associated with subsequent IA. Our findings highlight the potential significance of these PUFA metabolites in pre-RA populations.
フランスのポリネシア2013-14におけるZikaウイルス: 完成した発生の解剖学【JST・京大機械翻訳】
Authors: Musso Didier, Bossin Herve, Mallet Henri Pierre, Besnard Marianne, Broult Julien, Baudouin Laure, Levi Jose Eduardo, Sabino Ester C, Ghawche Frederic, Lanteri Marion C, Baud David
Journal: The Lancet Infectious Diseases (2018)
Abstract 16238: Pregnancy-Related Events Associated With Subclinical Cardiovascular Disease Burden in Late Midlife: SWAN
Authors: Yamnia I Cortes, Maria Brooks, Janet M Catov, Samar R El Khoudary, Rebecca C Thurston, Karen A Matthews, Carmen R Isasi, Elizabeth A Jackson, Emma Barinas-Mitchell
Journal: Circulation (2018)

Background and Aim: Reproductive factors (e.g., age at menarche, age at first birth, preeclampsia, gestational diabetes) have been associated with later life cardiovascular disease (CVD) in women, ...
Abstract 16185: The Relationship Between Atrial Fibrillation and Coffee
Authors: Nandini Mehra, Christopher DeSimone, David Hodge, Abhishek Deshmukh, Alexander C Egbe, Malini Madhavan
Journal: Circulation (2019)

Introduction: Coffee is one of the most popular beverages in the world. In 2018, it was estimated that approximately 2.25 billion cups of coffee are consumed worldwide daily. Multiple studies have ...
Spectrum of AKI in Patients with COVID-19 Infection
Authors: Irtiza Hasan, Vishal Jaikaransingh, Abdalagani A. Abakar Baher, Jose S. Reyes Oliva, Charles W. Heilig
Journal: Journal of the American Society of Nephrology (2020)

Hasan, Irtiza; Jaikaransingh, Vishal; Abakar Baher, Abdalagani A.; Reyes Oliva, Jose S.; Heilig, Charles W. Author Information