tbuckley/cabot-search huggingface dataset:
Abstract 18681: Moderate Alcohol Consumption at Midlife and Successful Survival in Women at Age 70 Years and Older
Authors: Qi Sun, Meir J Stampfer, Mary K Townsend, Olivia I Okereke, Eric B Rimm, Frank B Hu, Francine Grodstein
Journal: Circulation (2010)

Background: Observational studies have consistently documented inverse associations between moderate alcohol consumption and risk of many major chronic diseases, as well as overall mortality. It is...
Abstract 14280: RP105, a Toll Like Receptor 4 (TLR4) homolog, moderates restenosis and outward remodeling.
Authors: Jacco C Karper, Mark M Ewing, Margreet R de Vries, M Lourdes Sampietro, J Wouter Jukema, Paul H A Quax
Journal: Circulation (2010)

Introduction: RP105, a homolog of TLR4, is a physiological endogenous inhibitor of TLR4 signaling. Previously, we and others have shown that TLR4 is involved in restenosis, vein graft disease and a...
Abstract 9297: ST-Segment Category at Acute Presentation is Associated with Time Course of Coronary Artery Disease Progression in Patients with Acute Coronary Syndromes
Authors: Tatsuya Nakachi, Nao Ishii, Yuka Kusakawa, Shingo Kato, Kazuhiro Muto, Yasuo Ohkusu, Takeshi Nakagawa, Kazuki Fukui, Satoshi Umemura, Kazuo Kimura
Journal: Circulation (2011)

Background: Acute coronary syndrome (ACS) is categorized, according to the presenting electrocardiogram, into ST-segment elevation ACS (STEACS) and non-ST-segment elevation ACS (NSTEACS). Several studies have shown that early mortality was higher for STEACS, but late mortality remained consistently higher for NSTEACS. However, its underlying mechanism is unclear. Methods: We studied 219 patients (179 men, age 64 + 10 years) with STEACS (n= 93) or NSTEACS (n = 126) who underwent percutaneous coronary intervention (PCI) for culprit lesion during initial hospitalization. Estimated glomerular filtration rate (eGFR) was calculated according to MDRD study formula at initial presentation. All patients underwent serial coronary angiograms (CAGs) performed immediately before PCI ,and at 6 + 3 months and 60 + 10 months after presentation. Coronary artery disease progression (CP) was defined as an increase &gt; 15 % in stenosis severity of lesion in nonculprit artery between 2 serial CAGs. Results: There were no significant differences in age, sex, coronary risk factors, lipid profiles, eGFR, multivessel disease, follow-up periods and medication between STEACS and NSTEACS. The rate of CP between first and second CAGs did not differ according to ST-segment category at acute presentation. Compared to STEACS, NSTEACS had higher rate of CP between second and final CAGs (Figure). Multivariate analysis revealed that the independent predictors of CP between second and final CAGs were NSTEACS (odds ratio 3.01, 95% CI 1.52 to 5.94, p=0.002), eGFR &lt; 60 ml/min/1.73m 2 (odds ratio 2.32, 95% CI 1.11 to 4.84, p=0.025) , and diabetes mellitus (odds ratio 2.18, 95% CI 1.12 to 4.21, p=0.021). Conclusion: ST-segment category at initial presentation is associated with the persistency of the widespread coronary disease activity following presentation in patients with ACS undergoing PCI. This may partly explain the time-dependent differences in outcomes among patients with STEACS and NSTEACS.
The pharmacodynamic effect on cardiac repolarization of combination single dose ZD6474 and ondansetron in healthy subjects
Authors: T. Hammett, S. Oliver, P. Ghahramani, S. Kennedy, I. Fisher, E. Gilmore, T. Duvauchelle, R. Smith
Journal: Journal of Clinical Oncology (2005)

3197 Background: ZD6474, a selective inhibitor of VEGFR-2 and EGFR tyrosine kinase activity, is being evaluated in combination with certain chemotherapy agents as part of an ongoing Phase II program. Ondansetron (OND), a 5-HT3 antagonist known to prolong the QTc interval, is widely used for chemotherapy-induced emesis. Because of their likely concomitant use, this Phase I study investigated the potential for a pharmacodynamic interaction between ZD6474 and OND. Methods: Healthy male volunteers were recruited to this randomized, double-blind, 2-part study. In Phase A, subjects received OND (32 mg) or placebo via 15 min i.v. infusion, followed by the alternate regimen after 24 h washout. In Phase B, subjects received two single doses of ZD6474 (700 mg p.o.) at least 5 weeks apart, once in combination with OND and once with placebo (given 6 h after the ZD6474 dose). Pharmacokinetic (PK) sampling and continuous ECG monitoring were performed over 12 h (Phase A) or 24 h (Phase B). Results: Twenty-eight volunteers were enrolled (mean age 28 yrs, range 21–42). In Phase A, OND increased the QTc interval from baseline compared with placebo by a maximum of 12.45 ms on average (90% CI = 7.1–17.8 ms), at 30 min post-infusion. In Phase B, the average increase in QTc interval from baseline was 11.44 ms following ZD6474 + placebo, and 22.28 ms following ZD6474 + OND (both at 15 min post-infusion). The maximum additional effect of OND on QTc interval was therefore 10.84 ms, on average (90% CI = 4.4–17.3 ms), which is slightly less than additive compared with OND alone (Phase A). These changes were not considered to be of clinical concern in this study. Overall, no PK interaction between OND and ZD6474 was seen. Four patients were discontinued from the study: one in Phase A due to non-drug-related vomiting, and three in Phase B due to QTc prolongation as per protocol (>30 ms increase from baseline). No serious adverse events were reported. Conclusions: Because ZD6474/OND co-administration did not result in greater than additive effects on QTc prolongation, significant adverse cardiovascular effects would be unlikely with their concomitant use. ZD6474, both alone and in combination with OND, was well tolerated in healthy male volunteers. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration AstraZeneca AstraZeneca
"On-off" syndrome treated with lithium carbonate: a case report
Authors: D R Ross, C E Coffey, E L Ferren, J I Walker, C W Olanow
Journal: American Journal of Psychiatry (1981)

The authors describe a 42-year-old man who developed "on-off" episodes and for whom lithium carbonate proved an effective treatment. They speculate that the predominant effect of lithium in the "on-off" syndrome is to prevent L-dopa desensitization of the dopamine receptor.
Supraventricular Tachycardia
Authors: Etienne Delacrétaz
Journal: New England Journal of Medicine (2006)

A 28-year-old woman suddenly has rapid palpitations with dizziness while playing her cello. She is brought to an emergency department. She has a faint regular pulse of 190 beats per minute. Her blood pressure is 82/54 mm Hg. Cardiovascular examination reveals no signs of heart failure. An electrocardiogram shows a regular tachycardia with a narrow QRS complex and no apparent P waves. How should her case be managed?
Abstract 19483: Vitronectin Increases Vascular Permeability by Promoting Ve-Cadherin Internalization at Cell Junctions
Authors: Jianbo Wu, Elizabeth A Grunz, Tammy L Strawn, William P Fay
Journal: Circulation (2010)

Background:  Cross-talk between integrins and cadherins regulates cell function. We tested the hypothesis that vitronectin (VN), a multi-functional adhesion molecule present in extracellular matrix and plasma, regulates vascular permeability via effects on VE-cadherin (VE-Cad), a critical regulator of endothelial cell (EC) adhesion.   Methods:  We used confocal fluorescence microscopy, an in vitro permeability assay, and in vivo experiments involving wild-type (WT) and VN-deficient ( Vn  −/− ) mice to study the role of VN in regulating VE-cad trafficking in EC monolayers and endothelial cell barrier function.   Results:  Addition of multimeric VN (10 μg/mL) significantly increased VE-cadherin internalization in human umbilical vein EC (HUVEC) monolayers. This effect was blocked by anti-α V β 3  antibody and pharmacological inhibition and knockdown of Src kinase. Surprisingly, blockade of α V β 3  integrin and Src kinase after VN treatment triggered rapid translocation of internalized VE-Cad back to the cell surface, demonstrating the reversible nature of VE-Cad trafficking. In contrast to multimeric VN, monomeric VN did not trigger VE-Cad internalization. In a modified Miles assay, VN deficiency impaired vascular endothelial growth factor-induced permeability. Furthermore, ischemia-induced enhancement of vascular permeability, expressed as the ratio of FITC-dextran leakage from the circulation into ischemic and non-ischemic hindlimb muscle, was significantly greater in WT mice than in  Vn  −/−  mice (1.64x10 5  ± 0.09 vs. 1.05x10 5  ± 0.15, respectively, n=6/group; p=0.02). Similarly, ischemia-induced angiogenesis and macrophage infiltration were significantly reduced in  Vn  −/−  mice vs. WT controls.   Conclusions:  VN plays a previously unrecognized role in regulating endothelial permeability via conformational- and integrin-dependent effects on VE-Cad trafficking. VN regulates vascular permeability in vivo. These results have important implications regarding the regulation of endothelial function and angiogenesis by VN under normal and pathological conditions.
Mumps outbreak in Jerusalem affecting mainly male adolescents
Authors: C Stein-Zamir, H Shoob, N Abramson, E Tallen-Gozani, I Sokolov, G Zentner
Journal: Eurosurveillance (2009)

From mid-September 2009 to 7 December 2009, 173 cases of mumps have been reported in the Jerusalem District. Most cases (82.1%) were male adolescents (median age 14.5 years) who are students in religious boarding schools. The majority of them (74%) are appropriately vaccinated for their age; 67% had received two doses of mumps-containing vaccine. An epidemiologic connection has been reported with visitors from New York, some of whom had recently had mumps.
Abstract 19565: Genetically Imposed Hypocoagulability Inhibits Atherogenesis and Promotes Plaque Stability
Authors: Julian I Borissoff, Sarah T Loubele, Peter Leenders, Rene van Oerle, Karly Hamulyak, Sylvia Heeneman, Mat J Daemen, Jay L Degen, Henri M Spronk, Hugo ten Cate
Journal: Circulation (2010)

Introduction: Although the generation of thrombin is pivotal for hemostasis, thrombin may also be a potent mediator of cellular effects. By activating protease activated receptors, thrombin elicits...
Prevalence and Characteristics of TCFA and Degree of Coronary Artery Stenosis
Authors: Jinwei Tian, Harold Dauerman, Catalin Toma, Habib Samady, Tomonori Itoh, Shoichi Kuramitsu, Takenori Domei, Haibo Jia, Rocco Vergallo, Tsunenari Soeda, Sining Hu, Yoshiyasu Minami, Hang Lee, Bo Yu, Ik-Kyung Jang
Journal: Journal of the American College of Cardiology (2014)
The Value of Ureteric Meatoscopy in Obscure Diseases of the Kidney., A Study in Clinical and Operative Surgery.
Authors: Fenwick, E. Hurry , b.
Journal: JAMA (1904)

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Abstract 16809: Robust Vessel Forming Capability Of Endothelial Cells Which Are Differentiated From Human Pluripotent Stem Cells via a Novel Two-Dimensional Serum Free Differentiation System
Authors: Shin-Jeong Lee, Julie J Kim, Chanjin R Park, Sangsung Kim, Jaemin Byun, Ji Woong Han, Young-sup Yoon
Journal: Circulation (2011)

Background: Human pluripotent stem cells (hPSCs) which include human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) have emerged as an important source of endothelial cells (ECs) that can used for cardiovascular regenerative therapy. However, current EC differentiation systems have limitation in their efficiency and their clinical applicability due to the use of animal serum or feeders. To overcome this pitfall, we developed a novel two-dimensional differentiation system in which hPSCs can be efficiently differentiated into ECs without using embryoid body (EB) formation and animal derivatives. Methods and Results: We used three lines of hPSCs: two hESCs (H1 and H9) and one hiPSC line. First, these cells were induced to differentiate into the mesodermal lineage by being cultured onto collagen-coated plates with GSK3-β inhibitor for 3 days. These cells were then cultured under DMEM-F12 supplemented with KSR and defined angiogenic factors (VEGF, EGF, bFGF, heparin) followed by mechanical shear stress to the cultured cells. These cells expressed endothelial specific proteins such as CHD5 (VE-cadherin)(22±4%) and von Willebrand factor (vWF) (18±5%) by FACS, formed tubes when cultured in Matrigel, and expressed EC-specific genes (KDR, TIE2, CD34, eNOS, CDH5, vWF) measured by qRT-PCR analysis. We next sorted CDH5+ cells using MACS. To verify in vivo EC characteristics and vasculogenic potential of sorted CDH5+ cells in vivo, a Matrigel plug assay and a hindlimb ischemia model were employed. The sorted CDH5+ cells, pre-labeled with a DiI were injected into the ischemic limbs in the HLI model or injected into the backs of athymic mice after being mixed with Matrigel. Tissues were harvested 7 to 14 days after perfusion with an EC marker, isolectin B4. Confocal examination of the tissues showed robust incorporation of CDH5+ cells into vascular structures, suggesting functional vasculogenesis. Conclusions: We developed a novel stepwise, animal component-free, two-dimensional system to differentiate hPSCs into functional ECs. This system will serve as a useful platform for investigating endothelial development and the resultant ECs can be useful for treating ischemic cardiovascular diseases.
Abstract 12407: Anti-aging Gene Klotho Deficiency Causes Hypertension via Upregulation of Fibroblast Growth Factor 23
Authors: Mariano Schuman, Zhongjie Sun
Journal: Circulation (2013)

Background & Objective: The prevalence of hypertension increases with age. Klotho (KL) is a newly-discovered anti-aging gene. In humans, the KL levels decrease with age. In vivo KL gene delivery pr...
Abstract 16670: Anterior Myocardial Infarction and Low Ejection Fraction: Should We Anticoagulate?
Authors: Nicholas Buss, Scott Friedman, James DeVries
Journal: Circulation (2011)

Introduction: Left ventricular (LV) thrombus formation is a recognized complication in patients with anterior STEMI. Warfarin is often used in this setting to prevent thrombus formation despite limited data to support this practice. We sought to determine the incidence of LV thrombus formation and assess the clinical benefit of anticoagulation for prophylaxis against LV thrombus and ischemic stroke in patients presenting with anterior STEMI and reduced ejection fraction (EF) who were treated with early reperfusion therapies and dual antiplatelet agents. Methods: Consecutive patients (N=298) with anterior STEMI and low post-infarct EF (&lt;40%) presenting to a single center between 2001 and 2010 were identified using an institutional registry. Patient demographics, presence of LV thrombus, anticoagulation strategy, and clinical outcomes at 6 months were determined using chart review. Patients with thrombus on the initial post-infarct echocardiogram were excluded (N=26). The primary outcomes were bleeding, stroke, and death within 6 months of the infarct. Results: LV thrombus occurred in 8.7% of patients with anterior STEMI and EF &lt;40%. The incidence of clinically relevant bleeding was 13.2% and ischemic stroke was 2.2%.There was no significant difference in the rates of bleeding, stroke, or death based on treatment with warfarin (see table). There were four fatal bleeds, all occurring in patients on warfarin therapy. Conclusions: The incidence of LV thrombus in this high-risk group of patients with anterior STEMI and reduced EF is approximately 9%. The rate of ischemic stroke at 6 months was not affected by the addition of warfarin to dual antiplatelet therapy. In conclusion, the rate of thrombus formation and ischemic stroke were low, while the rate of clinically relevant bleeding was relatively high, suggesting that the routine use of warfarin for prophylaxis is not warranted.
Abstract 3481: Prognostic Utility of Serial Measurements of a Novel Biomarker ST2 in Stemi Patients Treated With Primary PCI
Authors: Marcin Grabowski, Filip M Szymanski, James L Januzzi, Alan H Wu, Anna Hrynkiewicz-Szymanska, Andrzej Cacko, Krzysztof J Filipiak, Janusz Kochman, Grzegorz Karpinski, Grzegorz Opolski
Journal: Circulation (2009)

Background: ST2 is a novel marker with prognostic value in acute heart failure and ST-elevation acute myocardial infarction (STEMI) treated with fibrinolysis. We evaluated the dynamic and prognosti...
Efficacy of Ranolazine in Patients With Chronic Angina
Authors: Sean R. Wilson, Benjamin M. Scirica, Eugene Braunwald, Sabina A. Murphy, Ewa Karwatowska-Prokopczuk, Jacqueline L. Buros, Bernard R. Chaitman, David A. Morrow
Journal: Journal of the American College of Cardiology (2009)
Esophageal Stent in the Anus: An Unusual Presentation of Stent Migration
Authors: L Kazemi-Shirazi, A Püspök, R Schöfl, A Ferlitsch, M R Müller, A Gangl, G Novacek
Journal: Endoscopy (2003)

Implantation of prostheses is the principal option for palliative treatment of malignant dysphagia, but peri-interventional complications remain a concern. We report here on the case of a 71-year-old male patient with inoperable esophageal cancer who was admitted to our department with postprandial regurgitation, dysphagia, and inability to pass stool. He denied experiencing any pain or symptoms of bleeding. One month previously, a conventional esophageal plastic stent (11/60 esophageal tube, ESKA-Buess, Germany) had been implanted at an outside department to bridge a high-grade malignant stenosis located approximately 20 cm above the gastroesophageal junction; the tube did not bridge the cardia (Figure [1]). Physical examination revealed a stool-filled stent, visible in the anus. The esophageal plastic stent had passed through the entire gastrointestinal tract without causing any obvious migration-related symptoms or complications. It was easily removed from the anus manually.
Abstract 19439: Platelet COX-1 Independent TXA2 Generation in Acute Coronary Syndrome
Authors: Andrew P DeFilippis, Steve P Schulman, Roger S Blumenthal, Thomas S Kickler, Gary Gerstenblith, Jeffrey J Rade
Journal: Circulation (2010)

Introduction: Platelet activation via thromboxane A2 (TXA2) is fundamental to thrombus formation in acute coronary syndrome (ACS) patients. Aspirin inhibits platelet TXA 2 production by inhibiting the cyclooxygenase (COX-1) enzyme in platelets. Emerging data suggest, however, that ACS patients continue to generate TXA2 despite aspirin therapy, but it is unclear whether this TXA2 is from a failure of aspirin to inhibit platelet COX-1 or from platelet COX-1 independent sources. Hypothesis: Persistent TXA2 generation during ACS is derived from platelet COX-1 independent sources. Methods: Platelet COX-1 independent TXA2 generation was evaluated in 25 patients on aspirin undergoing coronary angiography for stable and unstable angina. Platelet COX-1 activity was assessed by light transmission aggregation to 0.5mmol L−1 of arachidonic acid (<10% aggregation defines appropriate aspirin inhibition of platelet COX-1 activity). TXA2 was evaluated by ELISA measurement of urine 11-dehydro thromboxane B2 (UTXB2), a sta...
Abstract 12553: Planning and Guidance of Cardiac Resynchronization Therapy Lead Implantation using Coronary Venous Anatomy with Multi-detector Computed Tomography
Authors: John Catanzaro, Amgad Makaryus, John Makaryus, Alexander Kaganas, Cristina Sison, Erik Altman, Stuart Beldner, Stanley Katz, Lawrence Boxt, Ram Jadonath
Journal: Circulation (2010)

Introduction: Coronary venous anatomical variation can affect lead placement and may warrant pre-implantation visualization prior to cardiac resynchronization therapy. We sought to evaluate the utility of 64 detector multi-detector computerized tomography (MDCT) to visualize coronary venous anatomy for pre-operative planning and lead placement. Methods: Prospective randomized enrollment of 23 patients (13 males;mean age 67.6 yrs) was undertaken. Patients were randomized to pre-implantation MDCT (GE Lightspeed, n=17) or no 64-CT (n=6). Implantation was planned based on 3D coronary venous reconstruction visualized in the MDCT group. Measurement of coronary sinus (CS) angulation, CS os diameter, right atrial dimensions was undertaken prior to implant. Intraoperative CS lead implantation times (introduction, cannulation and left ventricular positioning), procedure and fluoroscopy time, as well as venogram contrast volume were measured to determine if there was a difference between patients who underwent pre-i...
Abstract P142: Erythropoietin Administered after Resuscitation from Cardiac Arrest Improves Myocardial Function in a Rat Model of CPR
Authors: Morten Pytte, Shijie Sun, Wanchun Tang, Max H Weil
Journal: Circulation (2008)

Introduction : Erythropoietin (EPO) administered prior to or following either myocardial or cerebral infarction minimizes the severity of ischemic injury. We hypothesized that when EPO is administered after resuscitation from cardiac arrest, post resuscitation myocardial function and survival would improve. Methods : In an established model of cardiac arrest, ventricular fibrillation (VF) was electrically induced in 32 male SD rats weighing 520±20 g and left untreated for 8 minutes, followed by 6 minutes of pre-cordial compressions and attempted defibrillation. Resuscitated animals were randomized to receive either EPO 5000 units/kg, which was injected into the right atrium, or saline as a control. The primary investigator was blinded to the randomization. Dp/dt 40 and −dp/dt were calculated based on continuously measured left ventricular pressure. Ejection fraction (EF) measured echocardiographically and blood gases were both measured hourly for four hours. Survival was observed at 72 hours. Results : Twenty animals were successfully resuscitated and randomized. EPO significantly improved both EF and contractility as measured by dp/dt 40 . It also reduced the severity of post resuscitation hypo-perfusion based on arterial blood lactate measurements (Figure ). However, no statistically significant differences in survival were observed. Figure . Box plot of dp/dt 40, EF and arterial lactic acid. Conclusion : EPO improved myocardial function and minimized the severity of post-resuscitation perfusion failure. However, no persuasive survival benefit was demonstrated.