tbuckley/cabot-search huggingface dataset:
Conductive Hydrogels with Dynamic Reversible Networks for Biomedical Applications
Authors: Yong Xu, Michelle Patino Gaillez, Rebecca Rothe, Sandra Hauser, Dagmar Voigt, Jens Pietzsch, Yixin Zhang
Journal: Advanced Healthcare Materials (2021)

Abstract Conductive hydrogels (CHs) are emerging as a promising and well‐utilized platform for 3D cell culture and tissue engineering to incorporate electron signals as biorelevant physical cues. In conventional covalently crosslinked conductive hydrogels, the network dynamics (e.g., stress relaxation, shear shining, and self‐healing) required for complex cellular functions and many biomedical utilities (e.g., injection) cannot be easily realized. In contrast, dynamic conductive hydrogels (DCHs) are fabricated by dynamic and reversible crosslinks. By allowing for the breaking and reforming of the reversible linkages, DCHs can provide dynamic environments for cellular functions while maintaining matrix integrity. These dynamic materials can mimic some properties of native tissues, making them well‐suited for several biotechnological and medical applications. An overview of the design, synthesis, and engineering of DCHs is presented in this review, focusing on the different dynamic crosslinking mechanisms of DCHs and their biomedical applications.
LEFT ATRIAL APPENDAGE CLOSURE (LAAC) USING WATCHMAN DEVICE IN CHRONIC KIDNEY DISEASE (CKD) PATIENTS WITH ATRIAL FIBRILLATION: AN EXPLORATORY ASSESSMENT
Authors: Mohsin Mughal, Shakeel Jamal, Asim Kichloo, Ehizogie Edigin, Abdul Mannan Khan Minhas, Ronak Soni, Hasan Mirza, Maiwand Mirwais, Khalil Kanjwal
Journal: Journal of the American College of Cardiology (2021)
Long-term Physical and Psychological Outcomes of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis
Authors: Melissa Hoffman, Peter B. Chansky, Arjun R. Bashyam, Michelle A. Boettler, Nayanika Challa, Arturo Dominguez, Blanca Estupinan, Rachit Gupta, Kerry Hennessy, Shawna Nicole Huckell, Sara Hylwa-Deufel, Nicole A. Karikari, Jesse J. Keller, Daniela Kroshinsky, Sara A. Kullberg, Eden Lake, Karen J. Lee, Edgar Martinez, Kathryn Michels, Arash Mostaghimi, William Murphy, Fnu Nutan, Montana Osler, Vartan Pahalyants, Tejesh Patel, Lucia Seminario-Vidal, Lindsay C. Strowd, John Trinidad, Adam Vaudreuil, Lindsey M. Voller, Robert G. Micheletti
Journal: JAMA Dermatology (2021)

Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is known to cause multiple end-organ complications in its acute phase, but less is known about the long-term association with patients' mental health and quality of life.To examine the chronic physical and psychological sequelae affecting patients with SJS/TEN.A survey study conducted at 11 academic health centers in the US evaluated 121 adults diagnosed with SJS/TEN by inpatient consultive dermatologists between January 1, 2009, and September 30, 2019.Patients completed a survey that included the following validated questionnaires: Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), Primary Care Post-Traumatic Stress Disorder Screen (PC-PTSD), and the 12-item Short Form Health Survey (SF-12). The survey also included questions created by the study team regarding fear, patient education, and long-term sequelae relevant to SJS/TEN.Primary outcome measures were the percentage of patients reporting long-term physical sequelae; the percentage of patients with positive results on PHQ-9, GAD-7, and PC-PTSD screening; and the numeric score on the SF-12 (score of 50 defined as average physical and mental well-being).A total of 121 individuals (73 women [60.3%]; mean [SD] age, 52.5 [17.1] years) completed the survey (response rate, 29.2%). The most common long-term physical sequelae reported were cutaneous problems (102 of 121 [84.3%]), ocular problems (72 of 121 [59.5%]), and oral mucosal problems (61 of 120 [50.8%]). A total of 53.3% (64 of 120) of the respondents had results indicating depression on the PHQ-9, 43.3% (52 of 120) showed signs of anxiety on the GAD-7, and 19.5% had results indicating PTSD on the PC-PTSD. The mean (SD) SF-12 Physical Component Summary score was 42.4 (22.8), and the mean Mental Component Summary score was 46.1 (20.9). A total of 28.2% (33 of 117) of the respondents were unable to work, 68.1% (81 of 119) were fearful of taking new medications, and 30.0% (36 of 120) avoided taking prescribed medications for a diagnosed medical condition.This survey study found that long-term physical sequelae, depression, and anxiety appear to be common in patients with SJS/TEN, with implications for health and well-being. Improved awareness of these complications may assist health professionals in offering medical care, counseling, and support to patients with SJS/TEN.
EPHB2 Activates β-Catenin to Enhance Cancer Stem Cell Properties and Drive Sorafenib Resistance in Hepatocellular Carcinoma
Authors: Hoi Wing Leung, Carmen Oi Ning Leung, Eunice Y. Lau, Katherine Po Sin Chung, Etienne H. Mok, Martina Mang Leng Lei, Rainbow Wing Hei Leung, Man Tong, Vincent W. Keng, Cong Ma, Qian Zhao, Irene Oi Lin Ng, Stephanie Ma, Terence K. Lee
Journal: Cancer Research (2021)

Abstract The survival benefit derived from sorafenib treatment for patients with hepatocellular carcinoma (HCC) is modest due to acquired resistance. Targeting cancer stem cells (CSC) is a possible way to reverse drug resistance, however, inhibitors that specifically target liver CSCs are limited. In this study, we established two sorafenib-resistant, patient-derived tumor xenografts (PDX) that mimicked development of acquired resistance to sorafenib in patients with HCC. RNA-sequencing analysis of sorafenib-resistant PDXs and their corresponding mock controls identified EPH receptor B2 (EPHB2) as the most significantly upregulated kinase. EPHB2 expression increased stepwise from normal liver tissue to fibrotic liver tissue to HCC tissue and correlated with poor prognosis. Endogenous EPHB2 knockout showed attenuation of tumor development in mice. EPHB2 regulated the traits of liver CSCs; similarly, sorted EPHB2High HCC cells were endowed with enhanced CSC properties when compared with their EPHB2-Low counterparts. Mechanistically, EPHB2 regulated cancer stemness and drug resistance by driving the SRC/AKT/GSK3β/β-catenin signaling cascade, and EPHB2 expression was regulated by TCF1 via promoter activation, forming a positive Wnt/β-catenin feedback loop. Intravenous administration of rAAV-8-shEPHB2 suppressed HCC tumor growth and significantly sensitized HCC cells to sorafenib in an NRAS/AKT-driven HCC immunocompetent mouse model. Targeting a positive feedback loop involving the EPHB2/β-catenin axis may be a possible therapeutic strategy to combat acquired drug resistance in HCC. Significance: This study identifies a EPHB2/β-catenin/TCF1 positive feedback loop that augments cancer stemness and sorafenib resistance in HCC, revealing a targetable axis to combat acquired drug resistance in HCC.
Safety and immunogenicity of one versus two doses of the COVID-19 vaccine BNT162b2 for patients with cancer: interim analysis of a prospective observational study
Authors: Leticia Monin, Adam G Laing, Miguel Muñoz-Ruiz, Duncan R McKenzie, Irene del Molino del Barrio, Thanussuyah Alaguthurai, Clara Domingo-Vila, Thomas S Hayday, Carl Graham, Jeffrey Seow, Sultan Abdul-Jawad, Shraddha Kamdar, Elizabeth Harvey-Jones, Rosalind Graham, Jack Cooper, Muhammad Khan, Jennifer Vidler, Helen Kakkassery, Shubhankar Sinha, Richard Davis, Liane Dupont, Isaac Francos Quijorna, Charlotte O'Brien-Gore, Puay Ling Lee, Josephine Eum, Maria Conde Poole, Magdalene Joseph, Daniel Davies, Yin Wu, Angela Swampillai, Bernard V North, Ana Montes, Mark Harries, Anne Rigg, James Spicer, Michael H Malim, Paul Fields, Piers Patten, Francesca Di Rosa, Sophie Papa, Timothy Tree, Katie J Doores, Adrian C Hayday, Sheeba Irshad
Journal: The Lancet Oncology (2021)

The efficacy and safety profiles of vaccines against SARS-CoV-2 in patients with cancer is unknown. We aimed to assess the safety and immunogenicity of the BNT162b2 (Pfizer-BioNTech) vaccine in patients with cancer.
Willpower needs tactical skill
Authors: Juan Pablo Bermúdez
Journal: Behavioral and Brain Sciences (2021)

Abstract Ainslie advances our understanding of self-control by theoretically unifying multiple forms of willpower. But one crucial question remains unanswered: How do agents pick the right forms of willpower in each situation? I argue that willpower requires tactical skill , which detects willpower-demanding contexts, selects context-appropriate tactics, and monitors their implementation. Research on tactical skill will significantly advance our understanding of willpower.
Abstract 11829: Change in Body Mass Index and Long-term Risk of Stroke in Healthy Men
Authors: Erik Prestgaard, Julian Mariampillai, Kristian Engeseth, Per Torger Skretteberg, Jan Eriksson, Johan Bodegard, Knut Liestøl, Sverre E Kjeldsen, Irene Grundvold, Eivind Berge
Journal: Circulation (2019)

Background and Purpose: The impact of weight change on stroke risk is not well known. We aimed to examine the associations between early- and mid-life weight change and stroke risk during long-term...
Abstract 16435: Contemporary In-Hospital Outcomes of Chronic Total Occlusion Interventions: Update From the PROGRESS-CTO (prospective Global Registry for the Study of Chronic Total Occlusion Intervention) Multicenter International Registry
Authors: Judit Karacsonyi, Khaldoon Alaswad, Dimitrios Karmpaliotis, Oleg Krestyaninov, James Choi, Jaikirshan Khatri, Farouc A Jaffer, MITUL P PATEL, Ehtisham Mahmud, Anthony Doing, Philip Dattilo, David E Kandzari, Michalis Koutouzis, Ioannis Tsiafoutis, Barry F Uretsky, Catalin Toma, Robert W Yeh, Hector Tamez, R. Michael Wyman, Brian Jefferson, Taral Patel, Wissam Jaber, Habib Samady, Abdul Sheikh, Bilal Malik, Srinivasa Potluri, Basem Elbarouni, Michael Love, alpesh shah, Jeffrey Moses, Nicholas Lembo, Manish Parikh, Ajay J Kirtane, Ziad Ali, Evangelia Vemmou, Ilias Nikolakopoulos, Iosif Xenogiannis, Bavana V Rangan, Santiago Garcia, Subhash Banerjee, Imre Ungi, Emmanouil S Brilakis
Journal: Circulation (2020)

Introduction: Chronic total occlusion (CTO) percutaneous coronary intervention (PCI) has been advancing due to improvement of equipment, operator experience, and techniques. Methods: We examined contemporary outcomes of CTO PCI by analyzing the clinical, angiographic, and procedural characteristics of 7,031 CTO interventions performed in 6,984 patients at 35 participating centers between 2012 and 2020. Results: Mean age was 64.5 ± 10 years and 82% of the patients were men. The patients had high prevalence of comorbidities, such as diabetes (42%), prior coronary artery bypass graft surgery (29%), prior myocardial infarction (45%), and prior heart failure (29%). The most common CTO target vessel was the right coronary artery (53%), followed by the left anterior descending artery (26%), and left circumflex artery (20%). The mean J-CTO and PROGRESS scores were 2.41 ± 1.28 and 1.09 ± 1.01, respectively. The overall technical and procedural success rates were 85.9% and 83.8% and the rate of in-hospital major cardiac adverse events (MACE) was 2.06%. Technical success and procedural success rates were lower for higher values of J-CTO and PROGRESS scores, and MACE rate was higher ( Figure 1 ). The final successful crossing strategy was antegrade wire escalation in 53.7%, retrograde in 19.9%, and antegrade dissection reentry in 14.6%. The overall median air kerma radiation dose, contrast volume, procedure and fluoroscopy time were 2.30 (1.30, 3.90) Gray, 225 (160, 305) ml, 115 (75, 170) and 43 (26, 70) minutes, respectively. Conclusions: Using a combination of crossing strategies, high success and acceptable complication rates can be achieved in CTO PCI among various centers and patient populations.
BIOMECHANICAL FLOW MODELING USING PATIENT-SPECIFIC 3D PRINTED MODEDLS FOR SURGICAL DECISION-MAKING IN ANOMALOUS AORTIC ORIGIN OF CORONARY ARTERY
Authors: Yasaman Farsiani, Jayanthi Parthasarathy, Silvana Molossi, Carlos Mery, Atefeh Razavi, Lakshmi Prasad Dasi, Rajesh Krishnamurthy
Journal: Journal of the American College of Cardiology (2021)
Role of ras protooncogene in survival of patients with lung cancer: a systematic literature review and meta-analysis
Authors: Céline Mascaux, N Iannino, Benoît Martin, Marianne Paesmans, Thierry Berghmans, Michèle Dusart, Annick Haller, Philippe Lothaire, Anne-Pascale Meert, Jean-Jacques Lafitte, Jean-Paul Sculier
Journal: European Respiratory Journal (2004)
INCREMENTAL ROLE OF LEFT ATRIAL AND RIGHT VENTRICULAR STRAINS FOR PREDICTING CARDIOVASCULAR OUTCOME IN HEART FAILURE PRESERVED EJECTION FRACTION PATIENTS: A MACHINE LEARNING APPROACH
Authors: Selcuk Kucukseymen, Arghavan Arafati, Talal AlOtaibi, Hossam El-Rewaidy, Warren Manning, Reza Nezafat
Journal: Journal of the American College of Cardiology (2021)
Prolonged high-intensity exercise induces fluctuating immune responses to herpes simplex virus infection via glucocorticoids
Authors: Akimasa Adachi, Tetsuya Honda, Teruki Dainichi, Gyohei Egawa, Yosuke Yamamoto, Takashi Nomura, Saeko Nakajima, Atsushi Otsuka, Masamitsu Maekawa, Nariyasu Mano, Naoto Koyanagi, Yasushi Kawaguchi, Toshiaki Ohteki, Takashi Nagasawa, Koichi Ikuta, Akihiko Kitoh, Kenji Kabashima
Journal: Journal of Allergy and Clinical Immunology (2021)
A Butterfly Flaps Its Wings
Authors: Matthew Castelo
Journal: JAMA Neurology (2021)

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Assessing a Rare and Serious Adverse Event Following Administration of the Ad26.COV2.S Vaccine
Authors: Ruth A. Karron, Nigel S. Key, Joshua M. Sharfstein
Journal: JAMA (2021)

Isaac See, MD; John R. Su, MD, PhD, MPH; Allison Lale, MD, MPH; Emily Jane Woo, MD, MPH; Alice Y. Guh, MD, MPH; Tom T. Shimabukuro, MD, MPH, MBA; Michael B. Streiff, MD; Agam K. Rao, MD; Allison P. Wheeler, MD, MSCI; Suzanne F. Beavers, MD; Anna P. Durbin, MD; Kathryn Edwards, MD; Elaine Miller, RN, MPH; Theresa A. Harrington, MD, MPH&TM; Adamma Mba-Jonas, MD, MPH; Narayan Nair, MD; Duong T. Nguyen, DO; Kawsar R. Talaat, MD; Victor C. Urrutia, MD; Shannon C. Walker, MD; C. Buddy Creech, MD; Thomas A. Clark, MD, MPH; Frank DeStefano, MD, MPH; Karen R. Broder, MD
SOCIOECONOMIC PREDICTORS OF TELEMEDICINE ACCESS AMONG PATIENTS RECEIVING AMBULATORY CARDIOVASCULAR CARE DURING THE COVID-19 PANDEMIC
Authors: Kemar Brown, Daniela Crousillat, Njambi Mathenge, Jaclyn Pagliaro, Nava Katz, Connor Grady, Jagmeet Singh, Ami Bhatt
Journal: Journal of the American College of Cardiology (2021)
EVALUATION OF ADJUSTED INR GOAL IN PATIENTS WITH HEARTMATE 3 LEFT VENTRICULAR ASSIST DEVICES
Authors: Amanda Van Matre, Ayesha Ather, Emma Birks, Andrew Kolodziej, Rajasekhar Malyala, Adam Sieg, Rachel Unger, Maya Guglin, William Kuan
Journal: Journal of the American College of Cardiology (2021)
A HEART WITH AN UNUSUAL HOLE - HEART TRANSPLANTATION FOR ACUTE ENDOCARDITIS
Authors: Ruth Hsiao, David Bae, Marwah Shahid, Jesus Tello, Gabriel Vorobiof, Meshe Chonde, Michael DiVita, Darko Vucicevic, Arnold Baas, Megan Kamath
Journal: Journal of the American College of Cardiology (2021)
Will the 2021 USPSTF Hypertension Screening Recommendation Decrease or Worsen Racial/Ethnic Disparities in Blood Pressure Control?
Authors: Keith C. Ferdinand, Angela L. Brown
Journal: JAMA Network Open (2021)

US Preventive Services Task Force; Alex H. Krist, MD, MPH; Karina W. Davidson, PhD, MASc; Carol M. Mangione, MD, MSPH; Michael Cabana, MD, MA, MPH; Aaron B. Caughey, MD, PhD; Esa M. Davis, MD, MPH; Katrina E. Donahue, MD, MPH; Chyke A. Doubeni, MD, MPH; Martha Kubik, PhD, RN; Li Li, MD, PhD, MPH; Gbenga Ogedegbe, MD, MPH; Lori Pbert, PhD; Michael Silverstein, MD, MPH; James Stevermer, MD, MSPH; Chien-Wen Tseng, MD, MPH, MSEE; John B. Wong, MD
An NT-3-releasing bioscaffold supports the formation of TrkC-modified neural stem cell-derived neural network tissue with efficacy in repairing spinal cord injury
Authors: Ge Li, Bao Zhang, Jia-hui Sun, Li-yang Shi, Meng-yao Huang, Li-jun Huang, Zi-jing Lin, Qiong-yu Lin, Bi-qin Lai, Yuan-huan Ma, Bin Jiang, Ying Ding, Hong-bo Zhang, Miao-xin Li, Ping Zhu, Ya-qiong Wang, Xiang Zeng, Yuan-shan Zeng
Journal: Bioactive Materials (2021)

The mechanism underlying neurogenesis during embryonic spinal cord development involves a specific ligand/receptor interaction, which may be help guide neuroengineering to boost stem cell-based neural regeneration for the structural and functional repair of spinal cord injury. Herein, we hypothesized that supplying spinal cord defects with an exogenous neural network in the NT-3/fibroin-coated gelatin sponge (NF-GS) scaffold might improve tissue repair efficacy. To test this, we engineered tropomyosin receptor kinase C (TrkC)-modified neural stem cell (NSC)-derived neural network tissue with robust viability within an NF-GS scaffold. When NSCs were genetically modified to overexpress TrkC, the NT-3 receptor, a functional neuronal population dominated the neural network tissue. The pro-regenerative niche allowed the long-term survival and phenotypic maintenance of the donor neural network tissue for up to 8 weeks in the injured spinal cord. Additionally, host nerve fibers regenerated into the graft, making synaptic connections with the donor neurons. Accordingly, motor function recovery was significantly improved in rats with spinal cord injury (SCI) that received TrkC-modified NSC-derived neural network tissue transplantation. Together, the results suggested that transplantation of the neural network tissue formed in the 3D bioactive scaffold may represent a valuable approach to study and develop therapies for SCI.
DISPROPORTIONATE MITRAL REGURGITATION DETERMINES SURVIVAL IN ACUTE HEART FAILURE
Authors: Berrill Max, Ian Beeton, David Fluck, Isaac John, Otar Lazariashvili, Jack Stewart, Eshan Ashcroft, Jonathan Belsey, Pankaj Sharma, Aigul Baltabaeva
Journal: Journal of the American College of Cardiology (2021)
DIFFERENCES OF MITRAL VALVE GEOMETRY BETWEEN CENTRAL AND ECCENTRIC ATRIAL FUNCTIONAL MITRAL REGURGITATION: A THREE DIMENSIONAL TRANSESOPHAGEAL ECHOCARDIOGRAPHIC STUDY
Authors: Goki Uno, Taku Omori, Shunsuke Shimada, Mika Maeda, Shunsuke Kagawa, Takahiro Shiota
Journal: Journal of the American College of Cardiology (2021)
Survivors of gynecologic malignancies (GYN CA): Impact of treatment on health and well-being
Authors: S. N. Westin, C. C. Sun, R. A. Lacour, L. A. Meyer, C. S. Tung, D. L. Urbauer, M. M. Frumovitz, K. H. Lu, D. M. Gershenson, D. C. Bodurka
Journal: Journal of Clinical Oncology (2008)

5527 Background: While the overall survival from GYN CA has greatly improved over the last 3 decades, the treatments employed can lead to multiple health issues for survivors. Our objective was to determine the health concerns that face GYN CA survivors. Methods: As part of an ongoing study, a systematic, stratified sample of women with GYN CA seen at our institution from 1997 - 2007 was surveyed for 18 health issues occurring during or after treatment. Women were also asked to rank the issues in order of personal importance. The impact of treatment modality on health issues was assessed through multivariate logistic regression models. Results: To date, 2,286 survivors received surveys. Of the 781 (34%) completed, median age was 59 yrs; diagnoses included 29% cervical, 25% endometrial, 27% ovarian/primary peritoneal/fallopian tube, 18% vulvar/vaginal, and 1% other GYN CA. Median time from diagnosis was 4.8 yrs (range 0.5 - 57.6). The most frequently-reported health issues included: fatigue (43%), sexual dysfunction (35%), sleep disturbance (33%), neurologic issues (33%), urinary difficulties (32%), bowel complaints (31%), memory problems (30%), and depression (27%). These rankings were consistent when compared to patients’ self-reported rankings of “highest impact” personal issues: sexual dysfunction, bowel complaints, urinary difficulties, and fatigue. The table shows odds ratios for top health concerns by treatment modality after controlling for clinical/demographic variables such as diagnosis, treatment phase, and time from diagnosis. Conclusion: Our study demonstrates that GYN CA survivors experience a high frequency of health conditions and highlights the association between treatment modality and specific health concerns. These data reinforce the importance of identification and discussion of such survivorship issues throughout the continuum of care, as well as development of appropriate interventions to address the needs of GYN CA survivors. Impact of treatment modality on health issue frequency Treatment Modality n= 778 (% sample) Fatigue Sexual Neurologic Urinary Bowel Memory Surgery Only (33.2%) _ _ _ _ _ _ Chemo Only (0.9%) 0.8 * 1.8 * 3.1 * NA 3.2 * 2.0 * Rad Only (3.6%) 2.7 (1.2 - 6.1) 4.2 (1.6 - 11.3) 1.22 * 1.9 * 5.3 (2.2 - 12.8) 0.9 * Surg + Chemo (22.2%) 4.7 (3.1 - 7.3) 1.3 * 5.5 (3.5 - 8.7) 0.6 * 3.0 (1.6 - 5.6) 2.6 (1.6 - 4.1) Surg + Rad (13.6%) 2.1 (1.2 - 3.4) 3.1 (1.7 - 5.5) 2.0 (1.2 - 3.5) 2.1 (1.2 - 3.5) 7.3 (4.1 - 13.0) 1.4 * Chemo + Rad (8.9%) 3.1 (1.7 - 5.5) 2.0 (1.0 - 3.8) 3.0 (1.6 - 5.5) 2.4 (1.3 - 4.5) 5.0 (2.6 - 9.6) 1.6 * Surg + Chemo +Rad (17.6%) 5.5 (3.5 - 8.8) 4.8 (2.9 - 7.9) 8.1 (4.9 - 13.3) 3.0 (1.8 - 5.0) 7.4 (4.3 - 12.5) 3.1 (2.0 - 5.1) All values are OR (95% Confidence Intervals), * = 95% CI crosses 1 No significant financial relationships to disclose.