tbuckley/cabot-search huggingface dataset:
REDUCED COMPLETION RATES FOR INPATIENT VERSUS OUTPATIENT COLON &amp; PAN-INTESTINAL VIDEO CAPSULE ENDOSCOPY; A NESTED CASE-CONTROL STUDY
Authors: C. Deane, C. Walker, B. Ryan, A. O'Connor, S. O'Donnell, N. Breslin, D. McNamara
Journal: Endoscopy (2022)

Aims Inpatient video capsule endoscopy(VCE) is a regular request to gastroenterology services. Limited data exists comparing the effect of admission status on the quality of VCE. This study aimed to compare the quality of inpatient versus outpatient CCE(colon capsule endoscopy) & PIC(pan-intestinal capsule) studies & factors affecting outcomes.
OVERTUBES IN ENDOSCOPY: A SYSTEMATIC REVIEW
Authors: A. Martinez-Alcalá, L. Fry, K. Mönkemüller
Journal: Endoscopy (2022)

Aims Overtubes can be very helpful tools for complex endoscopies, such as foreign body extractions. Still, there is a paucity of data regarding other potential uses including placement of self-expanding metal stents and complex endoscopic resections. We aimed describe traditional and novels uses of overtubes in interventional endoscopy.
ENDOSCOPIC ULTRASOUND (EUS), CONTRAST-ENHANCED EUS AND FINE NEEDLE BIOPSY (FNB) OF PARAGASTRIC LESION
Authors: F. Fimiano, M. Sacco, A. Mauriello, F. Castellano, M. Gesualdo, A. Gambella, C.G. De Angelis
Journal: Endoscopy (2022)

This video presents a case of EUS guided FNB of a paragastric lesion. CH-EUS showed the pancreatic body marked by a hypoechoic oval mass which originated from the muscular layer of the posterior gastric wall of the body with rapid enhancement in arterial phase. FNB of the lesion with slowpull technique, both with 22G and 19G was performed and histology was consistent with Gastrointestinal Stromal Tumor. The new FNB, Franseen-tip 19G needles, could represent a great advance in FNB of GI submucosal lesions and macroscopic on site evaluation (MOSE) could predict the good quality of the specimen.
Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus: the PISCOS study
Authors: Matteo Piga, Elisabetta Chessa, Eric F Morand, Manuel F Ugarte-Gil, Maria Tektonidou, Ronald van Vollenhoven, Michelle Petri, Laurent Arnaud
Journal: The Lancet Rheumatology (2022)
204TiP A phase II study of HER3-DXD in patients (pts) with metastatic breast cancer (MBC)
Authors: E.P. Hamilton, N.A. Bagegni, J.T. Beck, J.L. Cultrera, O. Dosunmu, W.R. Gwin, A.L. Heeke, K. Khoury, D. Sellami, M. Shastry, D.W. Sternberg, D. Toppmeyer, V.M. Wright-Browne, Y. Yuan
Journal: Annals of Oncology (2022)
Epidermal growth factor receptor-dependent maintenance of cardiac contractility
Authors: Shuchi Guo, Ama Dedo Okyere, Erin McEachern, Joshua L Strong, Rhonda L Carter, Viren C Patwa, Toby P Thomas, Melissa Landy, Jianliang Song, Ana Maria Lucchese, Thomas G Martin, Erhe Gao, Sudarsan Rajan, Jonathan A Kirk, Walter J Koch, Joseph Y Cheung, Douglas G Tilley
Journal: Cardiovascular Research (2021)

Abstract Aims Epidermal growth factor receptor (EGFR) is essential to the development of multiple tissues and organs and is a target of cancer therapeutics. Due to the embryonic lethality of global EGFR deletion and conflicting reports of cardiac-overexpressed EGFR mutants, its specific impact on the adult heart, normally or in response to chronic stress, has not been established. Using complimentary genetic strategies to modulate cardiomyocyte-specific EGFR expression, we aim to define its role in the regulation of cardiac function and remodelling. Methods and results A floxed EGFR mouse model with α-myosin heavy chain-Cre-mediated cardiomyocyte-specific EGFR downregulation (CM-EGFR-KD mice) developed contractile dysfunction by 9 weeks of age, marked by impaired diastolic relaxation, as monitored via echocardiographic, haemodynamic, and isolated cardiomyocyte contractility analyses. This contractile defect was maintained over time without overt cardiac remodelling until 10 months of age, after which the mice ultimately developed severe heart failure and reduced lifespan. Acute downregulation of EGFR in adult floxed EGFR mice with adeno-associated virus 9 (AAV9)-encoded Cre with a cardiac troponin T promoter (AAV9-cTnT-Cre) recapitulated the CM-EGFR-KD phenotype, while AAV9-cTnT-EGFR treatment of adult CM-EGFR-KD mice rescued the phenotype. Notably, chronic administration of the β-adrenergic receptor agonist isoproterenol effectively and reversibly compensated for the contractile dysfunction in the absence of cardiomyocyte hypertrophy in CM-EGFR-KD mice. Mechanistically, EGFR downregulation reduced the expression of protein phosphatase 2A regulatory subunit Ppp2r3a/PR72, which was associated with decreased phosphorylation of phospholamban and Ca2+ clearance, and whose re-expression via AAV9-cTnT-PR72 rescued the CM-EGFR-KD phenotype. Conclusions Altogether, our study highlights a previously unrecognized role for EGFR in maintaining contractile homeostasis under physiologic conditions in the adult heart via regulation of PR72 expression.
120P AXSANA (AXillary Surgery After NeoAdjuvant Treatment) EUBREAST-3: An international prospective multicenter cohort study to evaluate different surgical methods of axillary staging in clinically node-positive breast cancer patients treated with neoadjuvant chemotherapy (NCT04373655)
Authors: F. Ruf, T. Kühn, S. Hartmann, J. de Boniface, O.D. Gentilini, E. Stickeler, G.K. Cakmak, I. Rubio, L. Niinikoski, M. Kontos, D. Murawa, E-A. Bonci, M. Hauptmann, M. Thill, H. Markus, M.P. Lux, M. Appelgren, J-U. Blohmer, M. Untch, M. Banys-Paluchowski
Journal: Annals of Oncology (2022)
2MO Development of a prognostic gene-expression signature for early stage HER2-positive breast cancer patients
Authors: S. Di Cosimo, C.M. Ciniselli, C. Sotiriou, K. Pogue-Geile, D. Fumagalli, E. de Azambuja, D. Venet, L. De Cecco, N. Pong, V. Cappelletti, E. Tagliabue, Y. Wang, C. Saura Manich, P.G. Nuciforo, S. Kuemmel, L. Pusztai, M.G. Daidone, S. Pizzamiglio, G. Pruneri, P. Verderio
Journal: Annals of Oncology (2022)
PLASTIC STENT VS LUMEN APPOSING METAL STENTS IN ENDOSCOPIC ULTRASOUND-GUIDED DRAINAGE OF WALLED-OFF PANCREATIC NECROSIS: A MULTICENTRE RANDOMISED TRIAL (THE PROMETHEUS STUDY)
Authors: J.G Velasquez-Rodriguez, F. Bas-Cutrina, E. Vazquez-Sequeiros, J.M. Esteban Lopez-Jamar, A. Teran-Lantaron, F. Gonzalez-Huix, M. Perez-Miranda, C. Guarner-Argente, J.J Vila-Costas, A. Garcia-Sumalla, A. Garcia Garcia De Paredes, J. Fisac-Vazquez, M. Moris, I. Miquel Salas, C. De La Serna Higuera, M. Murzi, S. Salord, J.R. Foruny, S. Ruiz-Osuna, N. Pelaez-Serra, M. Sanllorente, C. Tebe Cordomi, P. Hereu, J.B Gornals
Journal: Endoscopy (2022)

Aims Till date, there is not enough quality of evidence to recommend exclusively the use of LAMS. The main objective is to assess whether the theoretical benefit of LAMS is superior to DPS in the management of Walled-off necrosis (WON).
“COVESITY”: THE IMPACT OF SARS-COV-2 PANDEMIC ON SIX-MONTH WEIGHT TRAJECTORIES OF PATIENT UNDERWENT ENDOSCOPIC SLEEVE GASTROPLASTY IN A FOUR-YEAR PERIOD 2018-2021
Authors: G. Carlino, V. Bove, V. Pontecorvi, M.V. Matteo, M. De Siena, G. Giannetti, N. Antonini, C. Massari, G. Costamagna, I. Boškoski
Journal: Endoscopy (2022)

Aims To evaluate the effects of the pandemic on weight indices, a retrospective analysis on a prospective database of patients underwent Endoscopic Sleeve Gastroplasty (ESG) from 2018 and October 2021 was conducted, excluding patients enrolled in clinical trials.
TRAINEE PERFORMANCE IS CORRELATED WITH THE RISK OF PROCEDURE-RELATED ADVERSE EVENTS DURING HANDS-ON TRAINING ERCPS: RESULTS FROM THE INTERNATIONAL MULTICENTER TIERS STUDY
Authors: T.A. Voiosu, A. Bengus, M. Bronswijk, A. Voiosu, I. Boskoski, I. Klarin, B. Smarandache, P. Balanescu, I. Lyutakov, B. Busuioc, R.B. Mateescu, S. Wani, TIER S Study Group
Journal: Endoscopy (2022)

Aims Operator skill is a recognized risk factor for procedure related adverse events (AE) at ERCP. We aimed to study whether trainee technical performance as assessed by a validated instrument such as the TEESAT score can influence ERCP AE rates.
LATE PRESENTATION OF POST ROAD TRAFFIC ACCIDENT WITH COMPLETE COMMON BILE DUCT TRANSECTION MANAGED BY PTBD GUIDED RENDEVOUS BILIARY DRAINAGE
Authors: A. Kulkarni, V. Kulkarni, M. Kulkarni, A. Deshpande
Journal: Endoscopy (2022)

Post RTA total transection of CBD is a difficult senario to managed especially when presented late.this leads to healing by fibrosis with no obvious communication with distal CBD leading to persistant biliary leak which increases morbidity and mortality.We managed the case with percutaneous transhepatic approach to gain access to the proximal bile duct followed by creating a false passage by stiff end of a terumo guidewire into the duodenum through the papilla and completing procedure by ERC.She was followed up after 2 months and plastic stent was replaced by retrivable self expandable metal stent.
Endoscopic ultrasound-guided gallbladder drainage using a novel cautery-enhanced, endoscopist-deployed lumen-apposing metal stent
Authors: Lester Wei Lin Ong, Shannon Melissa Chan, Hon Chi Yip, Anthony Yuen Bun Teoh
Journal: Endoscopy (2022)

An 85-year-old woman presented with right upper abdominal pain and fever. Examination revealed tenderness in the right hypochondrium with a positive Murphy's sign. White cell count was 16.3 × 109/L, but liver function was normal. Transabdominal ultrasound confirmed acute cholecystitis with a 6-mm cystic duct stone. Owing to the patient's pre-existing Alzheimer's disease and frail pre-morbid condition, we decided for endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) after discussion with the patient's main caregiver [1] [2] [3].
MULTICENTER RETROSPECTIVE INTERNATIONAL STUDY TO EVALUATE OUTCOMES AND SAFETY OF PATIENTS UNDERGOING ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY COMBINING A SINGLE-USE CHOLANGIOSCOPE AND SINGLE-USE DUODENOSCOPE
Authors: A. Fugazza, M. Colombo, M. Kahaleh, R. Muthusamy, B. Bick, W. Laleman, C. Barbera, C. Fabbri, J. Nieto, A. Allehibi, N. Reddy, A. Tyberg, H. Shahid, A. Sarkar, D. Ehrlich, S. Sherman, C. Binda, M. Ramchandani, M. Spadaccini, A. Iannone, A. Anderloni, A. Repici
Journal: Endoscopy (2022)

Aims Duodenoscope-related multidrug-resistant organisms (MDRO) infections raise concerns. The introduction of disposable instruments onto the market has aroused interest, with excellent preliminary results. The aim of this study was to evaluate the performance of single-use duodenoscope in high complexity level ERCP.
BLEEDING PEPTIC ULCER: FACTORS OF LONG-TERM RECURRENCE
Authors: F. Amri, C. Belkhayat, Z. Taamouch, O. Elmqaddem, S. Rami, M. Oustani, M. Nassiri, A. Zazour, G. Kharrasse, W. Khannoussi, Z. Ismaili
Journal: Endoscopy (2022)

Aims The aim of our study is to identify the predictive factors associated with recurrent bleeding in peptic ulcers.
173P Entrectinib in NTRK fusion-positive (NTRK-fp) breast cancer: Updated data from STARTRK-2
Authors: J. Lu, C.M. Blakely, M. Barve, C.H. Chung, S.N. Waqar, X. Hu, J-P. Delord, M.J. Krzakowski, K. Yonemori, D.T. Chen, D. Klingbiel, S. Heinzmann, C. Le Tourneau
Journal: Annals of Oncology (2022)
46P Co-expression of GR with PR isoforms is associated with differential prognosis in estrogen receptor-positive breast cancer
Authors: V.P. Nimbalkar, V.P. Snijesh, S. Rajarajan, S. Patil, C.E. Anupama, R. Ramesh, B.S. Srinath, J.S. Prabhu
Journal: Annals of Oncology (2022)
Sample CME manuscript submission: Response to the article by Pham et al entitled “Review BRAF inhibition and the spectrum of granulomatous reactions”
Authors: Marion Marcaillou, Jeremie Dion, Barouyr Baroudjian, Emilien Ezrine, Cristina Carrera, Alisa Anderle, Zoe Apalla, Azael Freites-Martinez, Cécile Pages, Celeste Lebbe, Nicolas Meyer, Vincent Sibaud, Thibault Comont
Journal: Journal of the American Academy of Dermatology (2022)
Registry data analysis of hematopoietic stem cell transplantation on systemic chronic active Epstein–Barr virus infection patients in Japan
Authors: Masahide Yamamoto, Maho Sato, Yasushi Onishi, Yoji Sasahara, Hideki Sano, Masayoshi Masuko, Hirohisa Nakamae, Ken‐ichi Matsuoka, Takahide Ara, Kana Washio, Makoto Onizuka, Kenichiro Watanabe, Yoshiyuki Takahashi, Tsuneaki Hirakawa, Miwako Nishio, Chizuko Sakashita, Tohru Kobayashi, Akihisa Sawada, Tatsuo Ichinohe, Takahiro Fukuda, Yoshiko Hashii, Yoshiko Atsuta, Ayako Arai
Journal: American Journal of Hematology (2022)

The effects of allogeneic hematopoietic stem cell transplantation (allo-HSCT) on systemic chronic active Epstein-Barr virus infection (sCAEBV) are yet to be analyzed in a large number of patients. Using the Japanese registry database, Transplant Registry Unification Management Program, we investigated the outcomes of 102 sCAEBV patients who underwent allo-HSCT. The median age at HSCT was 21 years, and the three-year overall survival (3-year OS) rate was 72.5%. Of the 90 patients whose viral load after allo-HSCT was evaluated, 56 (62.2%) achieved a virological complete response, defined by the complete resolution of disease activity with a significant decrease in EBV-DNA in peripheral blood. The multivariate Cox proportional hazard model indicated that advanced age, in adolescents and young adults (AYA) (age, 15-39) and adults (age, ≥40 years) was a risk factor of poor OS. The hazard ratios (HRs) of the AYA and adult groups were 10.87 (95% confidence interval [CI]: 1.98-59.56, p = .006) and 15.93 (95% CI: 2.45-103.8, p = .004), respectively. Disease activity (HR 5.74), elevated soluble IL-2 receptor (sIL-2R) (≥ median, 691 U/mL) at HSCT (HR 6.93), and conditioning without radiotherapy (HR 3.53) were also independently associated with poor survival. Notably, 79% of radiotherapy doses were less than 6 Gy. Regardless of the presence of hemophagocytic lymphohistiocytosis, the group with a high sIL-2R level (≥2000 U/mL) showed a poorer prognosis. Although allo-HSCT is the only curative therapy for sCAEBV, treatment strategies need to be improved for high-risk patients, especially those with high levels of sIL-2R.
BLEEDING PARASTOMAL VARICES: ENDOSCOPIC ULTRASOUND TO THE RESCUE
Authors: J. Samanta, J. Dhar, P. Bharath, A. Kumar, H. Bhujade, P. Gupta, R. Kochhar
Journal: Endoscopy (2022)

Stomal varices are rare causes of variceal bleeding. Endoscopic ultrasound (EUS)-guided angiotherapy have not been reported earlier for parastomal varices. We present a 52-year gentleman, a diagnosed case of alcohol-related cirrhosis with ileostomy for tubercular abdominal cocoon, presented with stomal bleed. CT angiography revealed ileostomy with varicosities and two large vascular channels. Considering the poor general condition of the patient, EUS-guided angiotherapy was performed. In two sessions, 1 coil and 2 ml cyanoacrylate glue were injected each into the two separate vascular channels and the varices were obliterated. On 6-month follow-up, patient is doing fine with no further bleed.
MEDIO-GASTRIC PERORAL ENDOSCOPIC MYOTOMY (MG-POEM) IN THE MANAGEMENT OF POST-SLEEVE GASTRECTOMY (LSG) TWISTS: 4 CASES WITH VIDEO
Authors: J.-M. Gonzalez, M. Barthet
Journal: Endoscopy (2022)

Medio-gastric twists represent up to 4% of LSG, with challenging management. We propose MG-POEM to treat these patients.
Too Few Older Patients in Cancer Trials
Authors: Mike Mitka
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Coding variants identified in patients with diabetes alter PICK1 BAR domain function in insulin granule biogenesis
Authors: Rita C. Andersen, Jan H. Schmidt, Joscha Rombach, Matthew D. Lycas, Nikolaj R. Christensen, Viktor K. Lund, Donnie S. Stapleton, Signe S. Pedersen, Mathias A. Olsen, Mikkel Stoklund, Gith Noes-Holt, Tommas T.E. Nielsen, Mark P. Keller, Anna M. Jansen, Rasmus Herlo, Massimo Pietropaolo, Jens B. Simonsen, Ole Kjærulff, Birgitte Holst, Alan D. Attie, Ulrik Gether, Kenneth L. Madsen
Journal: Journal of Clinical Investigation (2022)

Bin/amphiphysin/Rvs (BAR) domains are positively charged crescent-shaped modules that mediate curvature of negatively charged lipid membranes during remodeling processes. The BAR domain proteins PICK1, ICA69, and the arfaptins have recently been demonstrated to coordinate the budding and formation of immature secretory granules (ISGs) at the trans-Golgi network. Here, we identify 4 coding variants in the PICK1 gene from a whole-exome screening of Danish patients with diabetes that each involve a change in positively charged residues in the PICK1 BAR domain. All 4 coding variants failed to rescue insulin content in INS-1E cells upon knock down of endogenous PICK1. Moreover, 2 variants showed dominant-negative properties. In vitro assays addressing BAR domain function suggested that the coding variants compromised BAR domain function but increased the capacity to cause fission of liposomes. Live confocal microscopy and super-resolution microscopy further revealed that PICK1 resides transiently on ISGs before egress via vesicular budding events. Interestingly, this egress of PICK1 was accelerated in the coding variants. We propose that PICK1 assists in or complements the removal of excess membrane and generic membrane trafficking proteins, and possibly also insulin, from ISGs during the maturation process; and that the coding variants may cause premature budding, possibly explaining their dominant-negative function.
Metabolic Alterations and WNT Signaling Impact Immune Response in HGSOC
Authors: Rebecca C. Arend, Carly B. Scalise, Emily R. Gordon, Allison M. Davis, McKenzie E. Foxall, Bobbi E. Johnston, David K. Crossman, Sara J. Cooper
Journal: Clinical Cancer Research (2022)

Abstract Purpose: Our study used transcriptomic and metabolomic strategies to determine the molecular profiles of HGSOC patient samples derived from primary tumor and ascites cells. These data identified clinically relevant heterogeneity among and within patients and highlighted global and patient-specific cellular responses to neoadjuvant chemotherapy (NACT). Experimental Design: Tissue from 61 treatment-naïve patients with HGSOC were collected. In addition, 11 benign, 32 ascites, and 18 post-NACT samples (matched to the individual patient's pre-NACT sample) were collected. RNA sequencing (RNA-seq) was performed on all samples collected. Two-dimensional spatial proteomic data was collected for two pairs of pre- and post-NACT. Untargeted metabolomics data using GCxGC-MS was generated for 30 treatment-naive tissues. Consensus clustering, analysis of differential expression, pathway enrichment, and survival analyses were performed. Results: Treatment-naïve HGSOC tissues had distinct transcriptomic and metabolomic profiles. The mesenchymal subtype harbored a metabolomic profile distinct from the other subtypes. Compared with primary tumor tissue, ascites showed significant changes in immune response and signaling pathways. NACT caused significant alterations in gene expression and WNT activity, and this corresponded to altered immune response. Overall, WNT signaling levels were inversely correlated with immune cell infiltration in HGSOC tissues and WNT signaling post-NACT was inversely correlated with progression-free survival. Conclusions: Our study concluded that HGSOC is a heterogenous disease at baseline and growing molecular differences can be observed between primary tumor and ascites cells or within tumors in response to treatment. Our data reveal potential exploratory biomarkers relevant for treatment selection and predicting patient outcomes that warrant further research.
Earliest Photic Zone Niches Probed by Ancestral Microbial Rhodopsins
Authors: Cathryn D. Sephus, Evrim Fer, Amanda K. Garcia, Zachary R. Adam, Edward W. Schwieterman, Betul Kacar
Journal: Molecular Biology and Evolution (2022)

Abstract For billions of years, life has continuously adapted to dynamic physical conditions near the Earth’s surface. Fossils and other preserved biosignatures in the paleontological record are the most direct evidence for reconstructing the broad historical contours of this adaptive interplay. However, biosignatures dating to Earth’s earliest history are exceedingly rare. Here, we combine phylogenetic inference of primordial rhodopsin proteins with modeled spectral features of the Precambrian Earth environment to reconstruct the paleobiological history of this essential family of photoactive transmembrane proteins. Our results suggest that ancestral microbial rhodopsins likely acted as light-driven proton pumps and were spectrally tuned toward the absorption of green light, which would have enabled their hosts to occupy depths in a water column or biofilm where UV wavelengths were attenuated. Subsequent diversification of rhodopsin functions and peak absorption frequencies was enabled by the expansion of surface ecological niches induced by the accumulation of atmospheric oxygen. Inferred ancestors retain distinct associations between extant functions and peak absorption frequencies. Our findings suggest that novel information encoded by biomolecules can be used as “paleosensors” for conditions of ancient, inhabited niches of host organisms not represented elsewhere in the paleontological record. The coupling of functional diversification and spectral tuning of this taxonomically diverse protein family underscores the utility of rhodopsins as universal testbeds for inferring remotely detectable biosignatures on inhabited planetary bodies.
Deltacron: Apprehending a new phase of the COVID-19 pandemic
Authors: Sazan Qadir Maulud, Dlshad Abdullah Hasan, Rezhna Khdir Ali, Rzgar Farooq Rashid, AbdulRahman A. Saied, Manish Dhawan, None Priyanka, Om Prakash Choudhary
Journal: International Journal of Surgery (2022)