tbuckley/cabot-search huggingface dataset:
Matrix compliance permits NF-κB activation to drive therapy resistance in breast cancer
Authors: Allison P. Drain, Nastaran Zahir, Jason J. Northey, Hui Zhang, Po-Jui Huang, Ori Maller, Johnathon N. Lakins, Xinmiao Yu, Jennifer L. Leight, Brenda P. Alston-Mills, E. Shelley Hwang, Yunn-Yi Chen, Catherine C. Park, Valerie M. Weaver
Journal: The Journal of Experimental Medicine (2021)

Triple-negative breast cancers (TNBCs) are associated with poor survival mediated by treatment resistance. TNBCs are fibrotic, yet little is known regarding how the extracellular matrix (ECM) evolves following therapy and whether it impacts treatment response. Analysis revealed that while primary untreated TNBCs are surrounded by a rigid stromal microenvironment, chemotherapy-resistant residual tumors inhabit a softer niche. TNBC organoid cultures and xenograft studies showed that organoids interacting with soft ECM exhibit striking resistance to chemotherapy, ionizing radiation, and death receptor ligand TRAIL. A stiff ECM enhanced proapoptotic JNK activity to sensitize cells to treatment, whereas a soft ECM promoted treatment resistance by elevating NF-κB activity and compromising JNK activity. Treatment-resistant residual TNBCs residing within soft stroma had elevated activated NF-κB levels, and disengaging NF-κB activity sensitized tumors in a soft matrix to therapy. Thus, the biophysical properties of the ECM modify treatment response, and agents that modulate stiffness-dependent NF-κB or JNK activity could enhance therapeutic efficacy in patients with TNBC.
Effects of alpha-adrenergic stimulation on intracellular sodium activity and automaticity in canine Purkinje fibers.
Authors: AZaza, R PKline, M RRosen
Journal: Circulation Research (1990)

Approximately 60% of adult canine Purkinje fibers respond to alpha 1-adrenergic stimulation with a decrease in automaticity. Recent studies of disaggregated Purkinje myocytes have suggested that this negative chronotropic effect results from alpha 1-adrenergic activation of the Na-K pump. In this study we evaluated 1) whether Na-K pump activation is associated with the negative chronotropic effect of alpha 1-adrenergic stimulation in adult canine Purkinje fibers and 2) if the effect of alpha-agonists on the pump is direct or mediated by an increase in intracellular sodium activity (aNai). We used sodium selective microelectrodes to determine the effects of 5 x 10(-9) and 5 x 10(-8) M phenylephrine on aNai. Phenylephrine decreased automaticity in five of eight Purkinje fibers while an increase occurred in the other three. The rate decrease was always accompanied by a decrease in aNai (-3.9 mM; p less than 0.05), whereas in fibers showing an increase in rate, aNai was unchanged. To evaluate the effect of ph...
Modulation of canine myocardial sarcolemmal membrane fluidity by amphiphilic compounds.
Authors: K LFink, R WGross
Journal: Circulation Research (1984)

Amphiphilic moieties such as lysophosphoglycerides and long-chain acyl carnitines accumulate in ischemic myocardium and potentially contribute to the sequelae of myocardial ischemia. To characterize alterations in membrane molecular dynamics produced by amphiphilic compounds, highly purified preparations of canine myocardial sarcolemma were spin-labeled with paramagnetic probes (5-, 12-, or 16-doxyl stearate), and alterations produced by amphiphilic compounds were quantified by electron spin resonance spectroscopy. Incorporation of 1.5, 3, or 6 mol % palmitoyl lysophosphatidylcholine resulted in a decrease of the order parameter of 16-doxyl stearate from 0.164 to 0.161, 0.155, and 0.145, respectively. Similar increases in membrane fluidity in the interior of the bilayer were present when palmitoyl lysophosphatidylethanolamine, L-palmitoyl carnitine, and platelet-activating factor were incorporated into sarcolemma. In contrast, incubation of sarcolemma with lysophosphatidylcholine did not result in signifi...
Anticoagulants in Acute Myocardial Infarction
Authors: J. de Swiet
Journal: BMJ (1969)

<h3>Abstract</h3> Our memories form a rich, colorful tapestry of emotions, events, people, and places, woven across the decades of our lives. However, research has typically been limited in its ability to assess the multidimensional nature of episodic memory, given the short time scales and artificial stimulus sets often required in experiments. In an era when people are constantly recording their lives through social media, we can now examine key questions about the behavioral and neural underpinnings of diverse and extensive real-world memories. Here, we tested the neural representations of episodic memory in a naturalistic setting, specifically focusing on the age, location, subjective memory strength, and emotional content of memories. We recruited 23 users of a video diary app (“1 Second Everyday”), who had recorded a total of 9,266 daily memory videos spanning up to 7 years prior to our study. During a 3T fMRI scan, participants viewed a set of 300 of their own memory videos intermixed with 300 videos from another individual. We identified key areas specifically engaged for one’s own memories versus another’s. Delving into the multidimensional nature of these memories, we find that their features are tightly interrelated, highlighting the need to consider these features in conjunction when conducting memory research. Importantly, when looking at the distinct contributions of these features, we find a topography of memory content extending across the medial parietal lobe with separate representations of a memory’s age, it’s strength, and the familiarity of the people and places involved.
A criss-cross heart with concordant atrioventriculo-arterial connections. Report of a case.
Authors: KSato, SOhara, ITsukaguchi, KYasui, TNakada, MTamai, YKobayashi, TKozuka
Journal: Circulation (1978)

A distinctive angiographic appearance is described in a case of  heart with concordant atrioventriculo-arterial connections. The atrial situs was normal, and the morphological right ventricle was superior to the left ventricle, and the ventricular septum was horizontal in position. Both ventricleswere connected by a small ventricular septal defect. The aorta was situated anteriorly and to the right of the pulmonary artery. Although the cardiac segment was the apparent [S,L,D] type, the heart had conconrdant atrioventriculo-arterial connections. The ventricular rotation of the solitus heart about the longitudinal and the anteroposterior axis affected the atrioventricular flows, the plane of the ventricular septum, the inflow and outflow tracts of the ventricles, the interrelationship of the great arteries, and the course of the left coronary artery. Using the recent definition of criss-cross heart, we classified the heart as solitus-concordant (l-rotated) -normal.
Persistent sinus nodal electrograms during abnormally prolonged postpacing atrial pauses in sick sinus syndrome in humans: sinoatrial block vs overdrive suppression.
Authors: PAsseman, BBerzin, DDesry, DVilarem, PDurand, CDelmotte, E HSarkis, JLekieffre, CThery
Journal: Circulation (1983)

A transvenous electrode catheter technique was used for direct recording of bipolar sinus node electrograms during postpacing atrial pauses. Multiple repetitive local sinus node electrograms during atrial quiescence validate sinus node electrograms. Such atrial pauses with sinus node electrograms are due to sinoatrial block; atrial pauses without sinus node electrograms are due to overdrive suppression or improper recording. Eight consecutive patients were prospectively selected on the basis of a corrected sinus node recovery time greater than 1500 msec during diagnostic electrophysiologic evaluation. Six patients had atrial pauses with sinus node electrograms; three patterns of sinus node electrograms during atrial pauses were observed. We conclude that (1) sinus node electrogram recording is of value in understanding the mechanism underlying postpacing atrial pauses; (2) atrial pauses are usually (6/8) caused by sinoatrial block; (3) three patterns of sinus node electrograms are observed, thus making in...
Accumulation of unesterified arachidonic acid in ischemic canine myocardium. Relationship to a phosphatidylcholine deacylation-reacylation cycle and the depletion of membrane phospholipids.
Authors: K RChien, AHan, ASen, L MBuja, J TWillerson
Journal: Circulation Research (1984)

Studies in ischemic canine left ventricle have shown that the depletion of membrane phospholipids is a critical event in the development of a sarcolemmal calcium permeability defect and associated irreversible myocyte injury. The mechanism of phospholipid loss is unclear, but may be due to the activation of endogenous phospholipases. Since arachidonic acid is a fatty acid found almost entirely in phospholipid, increases in arachidonate provide evidence for increased phospholipase activity. The present study was designed to examine the temporal relationship of the accumulation of free arachidonate with the onset of phospholipid depletion during fixed ligation of the left anterior descending coronary artery in canine myocardium. The following results were demonstrated in ischemic canine myocardium: (1) the accumulation of unesterified arachidonate is minimal during 10-30 minutes of ischemia, but is significantly increased after prolonging the duration of ischemia to 1-3 hours; (2) significant increases in a...
Prodromal neuroinflammatory, cholinergic and metabolite dysfunction detected by PET and MRS in the TgF344-AD transgenic rat model of AD: a collaborative multi-modal study
Authors: Aisling M Chaney, Francisco R Lopez-Picon, Sophie Serrière, Rui Wang, Daniela Bochicchio, Samuel D Webb, Matthias Vandesquille, Michael K Harte, Christina Georgiadou, Catherine Lawrence, Julie Busson, Johnny Vercouillie, Clovis Tauber, Frédéric Buron, Sylvain Routier, Tristan Reekie, Anniina Snellman, Michael Kassiou, Johanna Rokka, Karen E Davies, Juha O Rinne, Dervis A Salih, Frances A Edwards, Llwyd D Orton, Stephen R Williams, Sylvie Chalon, Hervé Boutin
Journal: Theranostics (2021)

at the Aβ plaques locations, while NeuN labelling revealed an age-dependent decrease in hippocampal neuron number in both genotypes.Behavioural assessment using the novel object recognition task revealed that both WT & TgF344-AD animals discriminated the novel from familiar object at 3 m and 6 m of age.However, low levels of exploration observed in both genotypes at later time-points resulted in neither genotype successfully completing the task.Deficits in social interaction were only observed at 3 m in the TgF344-AD animals.By in vivo MRS, we showed a decrease in neuronal marker N-acetyl-aspartate in the hippocampus at 18 m (-18% vs age-matched WT, and -31% vs 6 m TG) and increased Taurine in the cortex of TG (+35% vs age-matched WT, and +55% vs 6 m TG).Conclusions.This multi-centre multi-modal study demonstrates, for the first time, alterations in brain metabolites, cholinergic receptors and neuroinflammation in vivo in this model, validated by robust ex vivo approaches.Our data confirm that, unlike mouse models, the TgF344-AD express Tau pathology that can be detected via PET, albeit later than by ex vivo techniques, and is a useful model to assess and longitudinally monitor early neurotransmission dysfunction and neuroinflammation in AD.
Thallium-201 myocardial scintigraphy in patients with triple-vessel disease and ischemic exercise stress tests.
Authors: JLeppo, TYipintsoi, RBlankstein, RBontemps, L MFreeman, LZohman, JScheuer
Journal: Circulation (1979)

Thirty patients with triple-vessel coronary artery disease proven by angiography, symptomatic angina and a positive ECG stress test were evaluated with thallium-201 (201TI) scintigraphy. Twenty patients also had aortocoronary saphenous vein bypass surgery; 15 of them had repeat noninvasive evaluation. Seventy percent of these patients showed ischemia by 201TI scintigraphy, of which one-half returned to normal after surgery. Postoperative reversion of the ECG stress test together with 201TI stress/reperfusion imaging correlated well with the completeness of surgical revascularization. We could not explain the prevalence (80%) of infarcts detected by 201TI in this group, of which 76% could be anatomically correlated to epicardial scars. The positivity of infarcts by 201TI exceeded that predicted by previous history of infarction, Q waves on resting ECG or ventriculographic akinesis. These observations suggest that 201TI scintigraphy is a useful noninvasive tool in the follow-up and understanding of patients...
TCTAP A-059 A Retrospective Case Control Study on Head-to-head Comparison Between LAAO and NOAC in Asian Population: Efficacy of Stroke Prevention and Bleeding Risk
Authors: Michael C.S. Chiang, Shing Fung Chui, Chan Alan, Vincent Luk, Sunny C.F. Tsang, Yuet Wong Cheng, Jason Leung Kwai Chan, Chi Yuen Wong, Michael Kang-Yin Lee, Kam Tim Chan
Journal: Journal of the American College of Cardiology (2021)
Letter: Psychiatry in the Soviet Union.
Authors: A King
Journal: BMJ (1974)

factors, including developmental and genetic, may underlie panacinar emphysema, which sometimes affects coal workers and becomes pigmented.Acquired fibrocystic disease, which in coal workers is often heavily pigmented, must also be distinguished from emphysema.On present evidence it is difficult to envisage a primary role for alveolar macrophages in the genesis of emphysema.Even in a,-antitrypsin deficiency, an un- common state in which leucocytic protease activity may be directed against connective tissue, other factor.smay co-operate in the genesis of emrphysema.The occurrence of alveolar fenestrae and capillary damage may merely represent the early stages of secondary non-specific disruption, which when advanced and widespread and possibly complicated by infection renders it difficult to assess the relative significance of the different pathogenetic processes in emphy- sema.-Iam, etc.,
Antibody responses to the BNT162b2 mRNA vaccine in individuals previously infected with SARS-CoV-2
Authors: Joseph E. Ebinger, Justyna Fert-Bober, Ignat Printsev, Min Wu, Nancy Sun, John C. Prostko, Edwin C. Frias, James L. Stewart, Jennifer E. Van Eyk, Jonathan G. Braun, Susan Cheng, Kimia Sobhani
Journal: Nature Medicine (2021)

Abstract In a cohort of BNT162b2 (Pfizer–BioNTech) mRNA vaccine recipients ( n = 1,090), we observed that spike-specific IgG antibody levels and ACE2 antibody binding inhibition responses elicited by a single vaccine dose in individuals with prior SARS-CoV-2 infection ( n = 35) were similar to those seen after two doses of vaccine in individuals without prior infection ( n = 228). Post-vaccine symptoms were more prominent for those with prior infection after the first dose, but symptomology was similar between groups after the second dose.
Positive expression and correlation of chemokine receptor CXCR4 with nodal metastasis and prognosis in colorectal cancer
Authors: K. Iqbal, M. Zhang
Journal: Journal of Clinical Oncology (2008)

15084 Background: Colorectal cancer is one of the leading causes of cancer related deaths, with recurrence and metastasis as the primary reasons for mortality. New evidence has implicated Chemokines as the likely cause. We studied the positive expression of CXCR4 chemokine receptors in colorectal carcinoma and investigated its correlations to clinicpathologic characteristics and prognosis Methods: Tumor tissue specimens of patients with colorectal carcinoma (n = 67) who underwent surgery from January 2003 to December 2004 at the Department of Surgery, Tongji Hospital were collected. CXCR4 expression levels and tumor micro vessel density were evaluated by immunohistochemistry. Specimens were immunostained using formalin-fixed, paraffin-embedded tissues. The correlation between the CXCR4 expression and clinicopathological factors was evaluated Results: In 67 cancer tissue specimens, CXCR4 was positively expressed in 38 cases; positive rate being 56.7%. Positive expression of CXCR4 is associated with an increase incidence of nodal involvement, higher clinic stage, higher tumor micro vessel density and a lower 3-year disease free survival rate as compared to those with negative CXCR4 expression (P<0.05). Conclusions: Positive CXCR4 expression and high tumor micro vessel density are associated with poor prognosis and could be a potential predictive factor for recurrence or metastasis of colorectal cancer patients. So CXCR4 may be a potential target for specific therapeutic interventions in the future. No significant financial relationships to disclose.
Endoscopic Diagnosis of Eosinophilic Esophagitis Using a deep Learning Algorithm
Authors: C Römmele, R Mendel, D Rauber, T Rückert, MF Byrne, C Palm, H Messmann, A Ebigbo
Journal: Endoscopy (2021)

Aims Eosinophilic esophagitis (EoE) is easily missed during endoscopy, either because physicians are not familiar with its endoscopic features or the morphologic changes are too subtle. In this preliminary paper, we present the first attempt to detect EoE in endoscopic white light (WL) images using a deep learning network (EoE-AI).
Reduced peak aerobic capacity in asymptomatic left ventricular systolic dysfunction. A substudy of the studies of left ventricular dysfunction (SOLVD). SOLVD Investigator. Studies of Left Ventricular Dysfunction.
Authors: T HLeJemtel, C SLiang, D KStewart, P CKirlin, K MMcIntyre, T HRobertson, AMoore, LCahill, MGalvao, K LWellington
Journal: Circulation (1994)

BACKGROUNDPeak oxygen consumption is reduced in patients with symptomatic congestive heart failure, but functional capacity of patients with asymptomatic left ventricular systolic dysfunction has not been assessed by measurement of peak oxygen consumption attained during graded exercise testing.METHODS AND RESULTSPeak oxygen consumption, that is, aerobic capacity (VO2, mL/kg per minute), was determined during graded treadmill exercise using the modified Naughton protocol in 40 patients with left ventricular systolic dysfunction (mean ejection fraction ranging from 14% to 35%; mean, 29%) who, while not receiving any cardiac medications, were totally asymptomatic, and in 41 age-matched normal subjects. Peak exercise duration and VO2 were significantly lower in patients with asymptomatic left ventricular systolic dysfunction than in normal subjects (948 +/- 273 versus 1239 +/- 372 seconds, P < .001, and 22.1 +/- 5.9 versus 29.8 +/- 7.7 mL/kg per minute, respectively, P < .001), while asymptomatic patients an...
Metoprolol does not attenuate atherosclerosis in lipid-fed rabbits exposed to environmental tobacco smoke.
Authors: Y PSun, B QZhu, R ESievers, S AGlantz, W WParmley
Journal: Circulation (1994)

BACKGROUNDWe previously demonstrated that exposure to environmental tobacco smoke (ETS) increases the development of atherosclerosis in lipid-fed rabbits. Clinical studies have suggested a protective effect of beta-blockers in smokers. Accordingly, we evaluated the effects of metoprolol in this animal model to see whether this beta-blocker would block the atherogenic effects of ETS.METHODS AND RESULTSThirty-two New Zealand White male rabbits on a 0.3% cholesterol diet were randomly divided into four groups: ETS-metoprolol (ETS-M), ETS-control (ETS-C), and non-ETS with metoprolol (NETS-M) and without metoprolol (NETS-C). The two metoprolol-treated groups received metoprolol at a dose of 0.4 mg.kg-1.h-1 administered subcutaneously by an osmotic pump. Rabbits in the ETS groups were exposed to sidestream smoke from four Marlboro cigarettes per 15 minutes, 6 hours a day, for 10 weeks. Average air carbon monoxide (CO), nicotine, and total particulates (TP) in the exposure chambers were 67.2 +/- 3.1 (SEM) ppm, 1...
Newspaper Reporting of Screening Mammography
Authors: Jane Wells, Phillip Marshall, Barbara Crawley, Kay Dickersin
Journal: Annals of Internal Medicine (2001)

Background: Continuing controversy surrounds screening mammography, particularly for women 40 to 49 years of age. Newspapers are potentially important sources of information on this topic, but it is not known whether they provide well-founded and objective information and recommendations. Objective: To examine how screening mammography is reported in newspapers. Design: Cross-sectional descriptive study. Setting: 6 top-circulation U.S. newspapers, 1990 to 1997. Measurements: Number of articles about screening mammography, issues covered by the articles, information sources, content and sources of quotes, recommendations cited in articles, and presentation of risks and benefits. Results: The most common theme of newspaper articles about mammography was screening for women 40 to 49 years of age. Thirty-one percent of the articles presented information without citing a source or justification. Quotes and recommendations in the articles were approximately twice as likely to support as to express reservations about mammography for women aged 40 to 49 years. Recommendations changed little over time and rarely reflected changes in recommendations of national organizations. Of the 102 articles describing the benefits of mammography, 95% expressed them in relative terms and 11% expressed them in absolute terms. Conclusions: Newspapers tended to overrepresent support for screening mammography for women aged 40 to 49 years. Reports would have been improved by identification of all sources for information cited, less reliance on relatively few sources, and discussion of benefits in absolute as well as relative terms. Medical journalism may benefit from identification of standards similar to those used for reporting medical research.
Use of Hirulog in the prevention of venous thrombosis after major hip or knee surgery.
Authors: J SGinsberg, M TNurmohamed, MGent, BMacKinnon, JSicurella, PBrill-Edwards, M NLevine, A APanju, PPowers, PStevens
Journal: Circulation (1994)

BACKGROUNDThe study objective was to determine whether Hirulog, a direct thrombin inhibitor, has potential efficacy and safety in the prevention of deep vein thrombosis (DVT) in orthopedic patients. A phase 2 open-label, dose-escalating design was used to study 222 unselected patients undergoing major hip or knee surgery in tertiary-care, university-affiliated hospitals.METHODS AND RESULTSSubcutaneous Hirulog was initiated postoperatively. Patients were evaluated for bleeding and symptomatic pulmonary embolism, and mandatory bilateral venography was performed before discharge. Dose escalations were made on the basis of observed rates of bleeding and venous thrombosis. There were five dosage regimens used: 0.3 mg/kg every 12 hours, 0.6 mg/kg every 12 hours, 1.0 mg/kg every 12 hours for 3 days followed by 0.6 mg/kg every 12 hours for up to 11 days, 1.0 mg/kg every 12 hours, and 1.0 mg/kg every 8 hours. One hundred seventy-seven patients who had technically adequate bilateral venography or objectively docume...
Inhibition of the activation and troponin calcium binding of dog cardiac myofibrils by acidic pH.
Authors: E MBlanchard, R JSolaro
Journal: Circulation Research (1984)

The aim of experiments described here was to test whether deactivation of cardiac myofibrils in acidic pH is associated with decreases in amounts of calcium bound to myofilament troponin. We determined the amounts of myofibrillar bound calcium attributable to troponin, from measurements of calcium binding to myofibrils and to myosin and from determination of the troponin C content of the myofibrillar preparations (0.40 nmol troponin C/mg protein). In measurements done at 2 mM free magnesium, 2 mM (magnesium-adenosine triphosphate, ionic strength 0.12, 22 degrees C, the pCa50 (-log of the half maximally activating molar free calcium) for myofibrillar magnesium-adenosine triphosphatase activity was 5.87 at pH 7.0, 5.49 at pH 6.5, and 5.04 at pH 6.2. This change in calcium sensitivity of myofibrillar magnesium-adenosine triphosphatase activity was present whether or not ethyleneglycol-bis(beta-aminoethyl ether)-N, N'-tetraacetic acid, was used to buffer the free calcium and whether or not myofibrillar tropon...