tbuckley/cabot-search huggingface dataset:
Multi-omic analysis of selectively vulnerable motor neuron subtypes implicates altered lipid metabolism in ALS
Authors: Hojae Lee, Jae Jin Lee, Na Young Park, Sandeep Kumar Dubey, Taeyong Kim, Kai Ruan, Su Bin Lim, Seong-Hyun Park, Shinwon Ha, Irina Kovlyagina, Kyung-tai Kim, Seongjun Kim, Yohan Oh, Hyesoo Kim, Sung-Ung Kang, Mi-Ryoung Song, Thomas E. Lloyd, Nicholas J. Maragakis, Young Bin Hong, Hyungjin Eoh, Gabsang Lee
Journal: Nature Neuroscience (2021)
Abstract 10447: Prognostic Significance of Circulating Monocyte Counts in Patients with Chronic Heart Failure
Authors: Takashi Komorita, Eiichiro Yamamoto, Koichi Egashira, Masafumi Takae, Fumi Oike, Koichiro Fujisue, Daisuke Sueta, Hiroki Usuku, Seiji Takashio, Kenichi Matsushita, Kenichi Tsujita
Journal: Circulation (2021)

Introduction: We previously reported that a high monocyte count was an independent and incremental of cardiovascular events in patients with coronary artery disease. To elucidate the prognostic value of monocyte in heart failure (HF), we investigated the association of monocyte counts in patients with HF with their future cardiovascular events. Methods: Consecutive HF patients referred for hospitalization at Kumamoto University Hospital between 2006 and 2013 were registered. We further divided HF patients into two types according to left ventricular ejection fraction (LVEF) (HF with reduced LVEF (HFrEF) and HF with preserved LVEF (HFpEF)). We defined high monocyte group as monocyte counts≥420/mm 3 in HFrEF patients and as monocyte counts≥308/mm 3 in HFpEF patients. Results: In this study, HFrEF was 200 patients and HFpEF was 478 patients. Kaplan-Meier analysis revealed that HFrEF patients with high monocyte group (≥420/mm 3 ) had a significant higher risk of HF-related events (P=0.001) compared with those with low monocyte groups (&lt;420/mm 3 ). By contrast, high and low monocyte groups in HFpEF patients had no significant difference in HF-related events. Multivariate Cox hazard analysis identified a high monocyte count as an independent and significant predictor of future HF-related events in HFrEF patients (hazard ratio:2.24, 95% confidence interval: 1.01-4.99, P=0.04). Conclusions: A high monocyte count was an independent and incremental predictor of HF-related events in HFrEF, but not in HFpEF patients.
Bleeding in Patients with Clinically Severe Von Willebrand Disease: Interim Analysis of Athn 9: A Natural History Study for People with Severe Von Willebrand Disease (VWD)
Authors: Angela C. Weyand, Martin Chandler, Carol Fedor, Kenneth D. Friedman, Sweta Gupta, Kristina M. Haley, Chunla He, Nikki Hirsh, Salley Pels, Jonathan C. Roberts, Tung T. Wynn, Robert F. Sidonio
Journal: Blood (2021)
Formaldehyde toxicity in age-related neurological dementia
Authors: Yiduo Kou, Hang Zhao, Dehua Cui, Hongbin Han, Zhiqian Tong
Journal: Ageing Research Reviews (2021)

The primordial small gaseous molecules, such as: NO, CO, H2S and formaldehyde (FA) are present in the brains. Whether FA as well as the other molecules participates in brain functions is unclear. Recently, its pathophysiological functions have been investigated. Notably, under physiological conditions, learning activity induces a transient generation of hippocampal FA, which promotes memory formation by enhancing N-methyl-D-aspartate (NMDA)-currents. However, ageing leads to FA accumulation in brain for the dysregulation of FA metabolism; and excessive FA directly impairs memory by inhibiting NMDA-receptor. Especially, in Alzheimer's disease (AD), amyloid-beta (Aβ) accelerates FA accumulation by inactivating alcohol dehydrogenase-5; in turn, FA promotes Aβ oligomerization, fibrillation and tau hyperphosphorylation. Hence, there is a vicious circle encompassing Aβ assembly and FA generation. Even worse, FA induces Aβ deposition in the extracellular space (ECS), which blocks the medicines (dissolved in the interstitial fluid) flowing into the damaged neurons in the deep cortex. However, phototherapy destroys Aβ deposits in the ECS and restores ISF flow. Coenzyme Q10, which scavenges FA, was shown to ameliorate Aβ-induced AD pathological phenotypes, thus suggesting a causative relation between FA toxicity and AD. These findings suggest that the combination of these two methods is a promising strategy for treating AD.
Real World Evidence (RWE) of Safety, Efficacy, and Outcomes of CD19 CAR-T Therapy in 20 Patients with Solid Organ Transplant (SOT)-Related Post-Transplant Lymphoproliferative Disorder (PTLD)
Authors: Jieqi Liu, Epperla Narendranath, Armin Ghobadi, Aleksandr Lazaryan, Uroosa Ibrahim, Caron Jacobson, Seema G Naik, Adam J. Olszewski, Yong Lin, Sayan Mullick Chowdhury, Miriam T. Jacobs, Loretta Nastoupil, Keren Osman, Sairah Ahmed, Andrew M. Evens
Journal: Blood (2021)
Pharmacological inhibition of BACE1 suppresses glioblastoma growth by stimulating macrophage phagocytosis of tumor cells
Authors: Kui Zhai, Zhi Huang, Qian Huang, Weiwei Tao, Xiaoguang Fang, Aili Zhang, Xiaoxia Li, George R. Stark, Thomas A. Hamilton, Shideng Bao
Journal: Nature Cancer (2021)
Quality of Life in Children, Adolescents and Young Adults with Sickle Cell Disease and Their Caregivers during Standard of Care and after Bone Marrow Transplantation: A Single Center Report
Authors: Vania Munaretto, Giulia Reggiani, Chiara Munerol, Elizabeth Maran, Marina Perdibon, Anna Chiara Frigo, Alessandra Biffi, Laura Sainati, Raffaella Colombatti
Journal: Blood (2021)
Biomimetic Scaffolds for Spinal Cord Applications Exhibit Stiffness‐Dependent Immunomodulatory and Neurotrophic Characteristics
Authors: Ian Woods, Cian O'Connor, Lisa Frugoli, Seán Kerr, Javier Gutierrez Gonzalez, Martyna Stasiewicz, Tara McGuire, Brenton Cavanagh, Alan Hibbitts, Adrian Dervan, Fergal J. O'Brien
Journal: Advanced Healthcare Materials (2021)

After spinal cord injury (SCI), tissue engineering scaffolds offer a potential bridge for regeneration across the lesion and support repair through proregenerative signaling. Ideal biomaterial scaffolds that mimic the physicochemical properties of native tissue have the potential to provide innate trophic signaling while also minimizing damaging inflammation. To address this challenge, taking cues from the spinal cord's structure, the proregenerative signaling capabilities of native cord components are compared in vitro. A synergistic mix of collagen-IV and fibronectin (Coll-IV/Fn) is found to optimally enhance axonal extension from neuronal cell lines (SHSY-5Y and NSC-34) and induce morphological features typical of quiescent astrocytes. This optimal composition is incorporated into hyaluronic acid scaffolds with aligned pore architectures but varying stiffnesses (0.8-3 kPa). Scaffolds with biomimetic mechanical properties (<1 kPa), functionalized with Coll-IV/Fn, not only modulate primary astrocyte behavior but also stimulate the production of anti-inflammatory cytokine IL-10 in a stiffness-dependent manner. Seeded SHSY-5Y neurons generate distributed neuronal networks, while softer biomimetic scaffolds promote axonal outgrowth in an ex vivo model of axonal regrowth. These results indicate that the interaction of stiffness and biomaterial composition plays an essential role in vitro in generating repair-critical cellular responses and demonstrates the potential of biomimetic scaffold design.
Indirect Treatment Comparisons of Daratumumab, Pomalidomide, and Dexamethasone Versus Daratumumab, Bortezomib, and Dexamethasone or Bortezomib and Dexamethasone in Patients with Difficult-to-Treat Relapsed/Refractory Multiple Myeloma
Authors: Jianming He, Heather Berringer, Bart Heeg, Tobias Kampfenkel, Harikumaran R. Dwarakanathan, Stephen Johnston, João Mendes, Annette Lam, Sacheeta Bathija, Eric Mackay
Journal: Blood (2021)
Haptoglobin 1-1 Isoform Predicts Higher Serum Haptoglobin Concentration and Lower Multiorgan Failure Risk in Sickle Cell Disease
Authors: Maria Armila Ruiz, David Shuey, Jin Han, Binal N. Shah, Richard Minshall, James P. Lash, Victor R. Gordeuk, Santosh L. Saraf
Journal: Blood (2021)
Conditionally Activated IL-12 or IFNα Indukine™ Molecules Inhibit Syngeneic Lymphoma Tumor Growth in Mice, Induce Anti-Tumor Immune Responses and Are Tolerated in Non-Human Primates
Authors: Philipp Steiner, Heather Brodkin, Josue Canales, Daniel Hicklin, Randi Isaacs, Nesreen Ismail, Kristin Morris, Christopher Nirschl, Andres Salmeron, Cindy Seidel-Dugan, Zoe Steuert, Jenna Sullivan, Ethika Tyagi, William Winston
Journal: Blood (2021)
Abstract 9166: Serum Level of Membrane Type 1-Matrix Metalloproteinase Inversely Corelates With Right Ventricular Systolic Pressure and Mean Pulmonary Artery Pressure in Pulmonary Hypertension
Authors: Koichi Sugimoto, Tomofumi Misaka, Akiomi Yoshihisa, Kazuhiko Nakazato, Takafumi Ishida, Yasuchika Takeishi
Journal: Circulation (2021)

Introduction: Pulmonary hypertension (PH) is defined as mean pulmonary arterial pressure (mean PAP) ≥ 25 mmHg and characterized by pulmonary vascular remodeling. Although right heart catheterization is essential for a definite diagnosis of PH, it is difficult to perform on all patients. Therefore, it is important to determine the new biomarker that predicts pulmonary arterial pressure. It has been reported that matrix metalloproteinase is associated with pulmonary vascular remodeling. Therefore, in this study, we focused on serum level of membrane type 1-matrix metalloproteinase (MT1-MMP) and examined its relationship with the hemodynamic indices in PH patients. Methods: Study subjects consisted of 44 patients with PH (idiopathic pulmonary arterial hypertension 9, chronic thromboembolic pulmonary hypertension 35). Serum level of MT1-MMP was measured by ELISA within 1 week before or after right heart catheterization. Results: The mean values of hemodynamic indices and MT1-MMP concentration of all patients were as follows: mean right atrial pressure, 6.5 ± 4.3 mmHg; right ventricular systolic pressure (RVSP), 74.0 ± 14.9 mmHg; mean PAP, 45.2 ± 9.5 mmHg; cardiac index, 2.5 ± 0.63 L/min/m 2 ; pulmonary vascular resistance, 10.0 ± 4.1 Wood unit; pulse pressure (PP), 46.4 ± 11.2 mmHg; MT1-MMP, 0.383 ± 0.082 ng/ml. MT1-MMP inversely correlated with RVSP, mean PAP, and PP (RVSP, R = -0.405, P &lt; 0.01; mean PAP, R = -0.316, P &lt; 0.05; PP, R = -0.413, P &lt; 0.01). Conclusions: Our results suggested that MT1-MMP might be a new biomarker reflecting the right ventricular pressure overload in pulmonary hypertension.
Abstract 13442: Renin-Angiotensin Metabolite Profiling via LC-MS/MS Reveals Sex Dependent Differences Induced by High-Salt Diet in Dahl-S Rats
Authors: Prabhatchandra R Dube, Chrysan J Mohammed, Fatimah Khalaf, Shungang Zhang, Dhilhani Faleel, Sophia Soehnlen, Jacob Connolly, Andrew Kleinhenz, Oliver Domenig, Lance Dworkin, Deepak Malhotra, Steven Haller, David J Kennedy
Journal: Circulation (2021)

Background: Understanding how sex influences the pathophysiology of cardiovascular and renal disease may enhance precision medicine approaches that account for sex specific biologic differences in these diseases. Nevertheless, characterization of preclinical models often fail to account for the role of sex on important pathophysiologic mechanisms. The renin-angiotensin-aldosterone system (RAAS) plays a central role in the development and progression of cardiovascular and renal disease. In addition to the classic RAAS pathway, an alternative RAAS pathway produces angiotensins (e.g. Ang [1-7]) that can counteract classical RAAS hormones such as Angiotensin (Ang) II. We hypothesized that RAAS profiling in a high-salt fed Dahl-S rat model would reveal significant sex differences in both classic and alternative RAAS pathways. Methods/Results: Ten week-old male and female Dahl-S rats were fed either 0.2% salt normal chow (SS-NC), or 8% high-salt diet (SS-HS) for eight weeks (n=6-8/group). Equilibrium RAAS profiling via LC-MS/MS was performed in lithium heparin plasma samples. In response to high-salt diet, both male and female SS-HS rats had significant (p&lt;0.05) reductions vs. their respective SS-NC controls in plasma aldosterone (-93% in male SS-HS, -97% in female SS-HS), Ang II (-71% in male SS-HS, -41% in female SS-HS), Ang IV (-79% in male SS-HS, -54% in female SS-HS) as well as calculated plasma renin activity (-67% in male SS-HS, -42% in female SS-HS), although the magnitude of reduction was generally greater in males vs. females. Alternatively, only male SS-HS rats had significant (p&lt;0.05 vs. SS-NC) reductions in plasma Ang I (-63%), Ang III (-66%), as well RAAS metabolites of the alternative RAS axis, Ang [1-5] (-58%) and Ang [1-7] (-70%) vs. SS-NC. Comparing female vs. male SS-HS rats, females had significantly (p&lt;0.01 vs. male) increased levels of angiotensins of the classic RAS pathway, such as Ang I (113%), Ang II (104%), Ang III (150%) and Ang IV (265%) after high-salt diet. Conclusion: High-salt diet induces significant sex-dependent differences in both classic and alternative RAAS pathways of Dahl-S rats and may provide important insight into the sex-dependent differences of cardiovascular and renal injury seen in this model.
A Phase 1 Study of the Combination of Acalabrutinib and AZD9150 in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Authors: Mark Roschewski, Veerendra Munugalavadla, Barrett Nuttall, Kathleen Burke, Melih Acar, Rafael White, Maria Udriste, Shringi Sharma, Brian Dougherty, Ian Flinn, Nakhle S. Saba, Patrick M. Reagan, Sven de Vos, Hendrik-Tobias Arkenau, Graham P. Collins, Andrew Mortlock, Manish R. Patel
Journal: Blood (2021)
I can drive in Iceland: Enabling international joint analyses
Authors: Chris Lunt, Joshua C Denny
Journal: Cell Genomics (2021)

In this issue of Cell Genomics, GA4GH reports key efforts to help share data across enclaves, including a framework for responsible data sharing, a data use ontology, and approaches for data use oversight. While there remains work in establishing reciprocity between data providers, we envision a future where joint analysis across enclaves is as easy as driving in different countries.
Prior History of Thrombosis, Meld, BMI and the Presence of Esophageal Varices Predict Thrombus Progression in Patients with Untreated Splanchnic Vein Thrombosis
Authors: Hannah Stowe McMurry, Jean Sabile, Ajay Mohinani, Sarah Patel, Sonia Gowda, Benjamin Elstrott, Liat Litwin, Joseph J Shatzel
Journal: Blood (2021)
Mitochondrial Electron Transport Chain Inhibition Promotes Resistance to Proteasome Inhibitors in Multiple Myeloma
Authors: Aditi Sharma, Abhinav Achreja, Remya Nair, Pulkit Gupta, Claudia L Edgar, Olamide Animasahun, Anjali Mittal, Bhakti Dwivedi, Manoj Bhasin, Vikas A Gupta, Benjamin G Barwick, Shannon M Matulis, Sagar Lonial, Lawrence H. Boise, David L Jaye, Arun P Wiita, Ajay K. Nooka, Deepak Nagrath, Mala Shanmugam
Journal: Blood (2021)
Gender Inequalities in Acute Myeloid Leukemia Poster Presentations at the American Society of Hematology: A Five-Year Trend
Authors: Vikram Sumbly, Frantzcess Compas, Harneet Kaur Grewal, Tanveer Shaukat, Saba Iqbal, Jonathan Ariyaratnam, Mohsen Alshamam, Katherine Keever, Faiz Anwer, Vincent Rizzo
Journal: Blood (2021)
Detection of CCND1 Overexpression By RNA-Seq from Tna Samples As a Surrogate for t(11:14) Translocation Traditionally Measured By FISH in Multiple Myeloma Patients for Improved Patient Care
Authors: Abhisek Ghosal, Francys Alarcon, Samuel Koo, Soo Jin Kang, Archana Ramesh, Tibor Gyuris, Segun C Jung, Brad B Thomas, Rudy Fabunan, Christophe Magnan, Hyunjun Nam, Paris Petersen, Fernando Lopez-Diaz, Susan Yamahata, Ryan Bender, Sally Agersborg, Fei Ye, Vincent Funari
Journal: Blood (2021)
Allogeneic Transplantation in Fit Older Adults Is Feasible and Encouragingly Efficacious. Post Remission Data from the Prospective ECOG-ACRIN (E2906) Clinical Study
Authors: Yishai Ofran, Zhuoxin Sun, Jacob M. Rowe, David F. Claxton, Martin S. Tallman, Daniel A. Arber, Ari Melnick, Ross L. Levine, Elisabeth Paietta, John E. Godwin, Hillard M Lazarus, Selina M. Luger, James M. Foran, Mark R. Litzow
Journal: Blood (2021)
Substantial Variation in Peripherally Inserted Central Catheter Use and Outcomes in Patients with Hematologic Malignancies: A Multi-Center Study
Authors: Marcus Geer, Urvashi Mitbander, Knut Taxbro, Qisu Zhang, Megan O'Malley, Jennifer Horowitz, Nithya Ramnath, Suman L Sood, Vineet Chopra
Journal: Blood (2021)
Ker-050, an Inhibitor of TGF- β Superfamily Signaling, Promoted Thrombopoiesis and Reversed Immune Thrombocytopenia in a Mouse Model of Disease
Authors: Marina Feigenson, Remya Nathan, Joshua Lamora, Ffolliott Fisher, Claire C Tseng, Jasbir Seehra, Jenn Lachey
Journal: Blood (2021)
Long-Term Cardiac Effects of Successful Non-Myeloablative HLA-Matched Sibling Transplants in Sickle Cell Disease
Authors: Vandana Sachdev, My-Le Nguyen, Wen Li, Neal Jeffries, Shalini S Ramachandra, David Tofovic, Damiano Rondelli, Matthew Hsieh, Santosh L. Saraf, Courtney D. Fitzhugh
Journal: Blood (2021)
COVID-19 in Children Following Hematopoietic Cell Transplantation: A Multinational Study of the European Bone Marrow Transplantation Society (EBMT) and the Spanish Group of Hematopoietic Stem Cell Transplantation (GETH)
Authors: Diana Averbuch, Rafael De La Camara, Selim Corbacioglu, Malgorzata Mikulska, Jose Luis Piñana Sanchez, Gloria Tridello, Nina Simone Knelange, Aleksandr D. Kulagin, Mouhab Ayas, Antonio Perez-Martinez, Amir Ali Hamidieh, Mikael Sundin, Rodrigo Martino, Petr Sedlacek, Simone Cesaro, Catherine Paillard, Brenda Gibson, Sarah Lawson, Nicolaus Kroeger, Jan Styczynski, Per Ljungman
Journal: Blood (2021)
The Compass-COVID19-ICU Study: Identification of Factors to Predict the Risk of Intubation and Mortality in Patients with Severe COVID-19
Authors: Patrick Van Dreden, Douglas D Fraser, Guillaume Voiriot, Aurélie Rousseau, Ismail Elalamy, Ioannis Prassas, Evangelos Terpos, Meletios A. Dimopoulos, Matthieu Grusse, Grigoris Gerotziafas
Journal: Blood (2021)
229 CX3CR1 in exhausted CD8 T cell states
Authors: Apoorvi Chaudhri, Yunfei Wang, Shao-Hsi Hung, Gregory Lizee, Ulrich Von Andrian, Patrick Hwu, Gordon Freeman
Journal: Journal for ImmunoTherapy of Cancer (2021)

Background Cancer has chronic antigen exposure that results in a suppressed CD8 T cell state termed exhaustion. An outcome of anti PD-1 blockade therapy is the expansion of early exhausted CD8+ T cells into a terminally differentiated exhausted state. The reversal of this transcriptionally plastic yet epigenetically fixed state of CD8 T cell exhaustion has the potential to increase responses to anti PD-1 therapy. Methods CX3CR1 is a marker of CD8 T cell activation, effector function however less is known about the contribution of CX3CR1 in CD8 T cell exhaustion. We identified three distinct subsets of CD8+ tumor infiltrating lymphocytes (TILs) based on high, mid, and negative CX3CR1 expression in a mouse model of colon carcinoma. Results The CX3CR1 high CD8+ T cells are more exhausted with higher PD1+TIM3+ expression compared to CX3CR1 mid and CX3CR1 negative cells thereby representing the terminal state of CD8 T cell exhaustion. Moreover, CX3CR1 high CD8 T cells increase following anti PD-1 blockade, and their abundance is associated with a positive response to anti PD-1. Conclusions We identify a consequence of CX3CR1 in terminal T cell exhaustion, and our work can offer strategies to increase responses to anti PD-1. Ethics Approval Animal experiments were performed as per the IACUC regulations at the Dana Farber cancer Institute, and the MD Anderson Cancer Center
An <i>EZH2</i> Gene Expression Signature Is Predictive of Differential Efficacy of Chemotherapy Irrespective of <i>EZH2</i> Mutation Status in Patients with Follicular Lymphoma Treated within the Gallium Trial
Authors: Verena Passerini, Vindi Jurinovic, Christopher R Bolen, Andrea Knapp, Alessia Bottos, Julia Richter, Jude Fitzgibbon, Wolfram Klapper, Andrew Davies, Robert Marcus, Michael von Bergwelt, Tina Nielsen, Martin H. Dreyling, Wolfgang Hiddemann, Michael Unterhalt, Eva Hoster, Oliver Weigert
Journal: Blood (2021)
A Prospective Comparison Analysis of Blood Biomarkers for the Diagnosis and Prediction of Sinusoidal Obstruction Syndrome
Authors: Naonori Harada, Hiroshi Okamura, Hideo Koh, Nao Tanizawa, Yosuke Makuuchi, Masatomo Kuno, Teruhito Takakuwa, Asao Hirose, Mika Nakamae, Mitsutaka Nishimoto, Yasuhiro Nakashima, Hirohisa Nakamae, Masayuki Hino
Journal: Blood (2021)
When I use a word . . . . Nasty medical eponyms
Authors: Jeffrey K Aronson
Journal: BMJ (2021)

When Jewish physicians and scientists were dismissed from their posts by the Nazis in the 1930s, or left voluntarily, their places were often taken by Nazi sympathizers, all too willing to take part in the various Nazi programmes of human experimentation, forced sterilization in the name of eugenics, euthanasia, and genocide. Several medical eponyms memorialize such individuals. However, alternative descriptions of the diseases, syndromes, tests, and therapies that they described are available. Such descriptions can and should be used in place of the eponymous attributions. There is some evidence that this is happening increasingly.
Synthetic Heparan Sulfate Compounds Attenuate Vascular Complications Associated with Sickle Cell Disease
Authors: Christina M Abrams, Erica Sparkenbaugh, Yongmei Xu, Chunsheng Chen, Kasemsiri Chandarajoti, Lantarima Bhoopat, John D Belcher, Gregory M. Vercellotti, Jian Liu, Rafal Pawlinski
Journal: Blood (2021)
Clinical and Molecular Characteristics of <i>TCF3-Hlf</i> Gene Fusion-Positive B-Cell Precursor Acute Lymphoblastic Leukemia: A Series of 24 Cases from a Large Cohort of Leukemia Patients
Authors: Xue Chen, Fang Wang, Yang Zhang, Xiaoli Ma, Lili Yuan, Jiancheng Fang, Cao Panxiang, Jiaqi Chen, Xiaosu Zhou, Ming Liu, Mingyue Liu, Hongxing Liu
Journal: Blood (2021)
Splenectomy for Primary Immune Thrombocytopenia Revisited at the Era of Thrombopoietin Receptor Agonists: New Insights for an Old Treatment
Authors: Arthur Mageau, Louis Terriou, Mikael Ebbo, Odile Souchaud-Debouverie, Corentin Orvain, Julie Graveleau, Jean-Christophe Lega, Marc Ruivard, Jean-Francois Viallard, Stephane Cheze, Antoine Dossier, Bernard Bonnotte, Antoinette Perlat, Delphine Gobert, Nathalie Costedoat-Chalumeau, Pierre-Yves Jeandel, Amandine Dernoncourt, Marc Michel, Bertrand Godeau, Thibault Comont
Journal: Blood (2021)
Pim Kinase Inhibitor Enhances FLT3 Inhibitor Efficacy through GSK-3β Activation and GSK-3β-Mediated Proteasomal Degradation of c-Myc
Authors: Jonelle K. Lee, Mario Scarpa, Aditi Chatterjee, Moaath Mustafa Ali, Prerna Singh, Shivani Kapoor, Rossana Trotta, Maria R. Baer
Journal: Blood (2021)
Advances toward structure-based drug discovery for inflammasome targets
Authors: Li Wang, Michael A. Crackower, Hao Wu
Journal: The Journal of Experimental Medicine (2021)

Inflammasome proteins play an important role in many diseases of high unmet need, making them attractive drug targets. However, drug discovery for inflammasome proteins has been challenging in part due to the difficulty in solving high-resolution structures using cryo-EM or crystallography. Recent advances in the structural biology of NLRP3 and NLRP1 have provided the first set of data that proves a promise for structure-based drug design for this important family of targets.
Preclinical Evaluation of a Novel Orally Bioavailable Menin-MLL Interaction Inhibitor, DSP-5336, for the Treatment of Acute Leukemia Patients with <i>MLL</i>-Rearrangement or <i>NPM1</i> Mutation
Authors: Ken Eguchi, Takafumi Shimizu, Daiki Kato, Yudai Furuta, Seiji Kamioka, Hitoshi Ban, Setsuko Ymamoto, Akihiko Yokoyama, Issay Kitabayashi
Journal: Blood (2021)
Karyosequencing: Integrating Genome-Wide and Targeted Sequencing for Comprehensive Diagnosis of Lymphoproliferative Disorders
Authors: James Peter Stewart, Louise Harewood, Shambhavi Srivastava, Jana Gazdova, Manisha Maurya, Sirintra Nakjang, Elizabeth Hodges, Laura Chiecchio, Nicholas C.P. Cross, Matthew W Jenner, Mark Catherwood, Sarra Ryan, Anthony V. Moorman, Nikos Darzentas, David Gonzalez
Journal: Blood (2021)