tbuckley/cabot-search huggingface dataset:
Metabolic dysfunction–associated fatty liver disease improves detection of high liver stiffness: The Rotterdam Study
Authors: Laurens A. van Kleef, Ibrahim Ayada, Louise J.M. Alferink, Qiuwei Pan, Robert J. de Knegt
Journal: Hepatology (2021)

Recently metabolic dysfunction-associated fatty liver disease (MAFLD) has been introduced and was defined as hepatic steatosis with either overweight, diabetes, and/or a combination of other metabolic risk factors. We investigated the application of the MAFLD criteria as compared with NAFLD.We performed a cross-sectional analysis within the Rotterdam Study, a large prospective population-based cohort. Participants who attended the liver ultrasound and transient elastography program between 2009 and 2014 were eligible for inclusion. Subsequently, individuals with viral hepatitis, alcohol intake >60 g/day, missing alcohol data, and/or missing body mass index were excluded. According to their NAFLD and MAFLD status based on metadata and ultrasound, participants were allocated in overlap fatty liver disease (FLD), NAFLD-only, MAFLD-only, or no FLD. Fibrosis was defined as liver stiffness ≥8.0 kPa. In our analysis, 5445 participants were included: 1866 (34.3%) had MAFLD and 1604 (29.5%) [Correction added on December 27, 2021 after first online publication: The preceding fragment was changed from "1623 (29.8%)"] had NAFLD. This resulted in 1547 (28.4%) [Correction added on December 27, 2021 after first online publication: The preceding fragment was changed from "1566 (28.8%)"] individuals with overlap FLD, 319 (5.9%) [Correction added on December 27, 2021 after first online publication: The preceding fragment was changed from "300 (5.5%)"] with MAFLD-only, 57 (1.0%) with NAFLD-only, and 3522 (64.7%) with no FLD. The MAFLD-only group was strongly associated with fibrosis (adjusted OR 5.30 [Correction added on December 27, 2021 after first online publication: The preceding fragment was changed from "OR 5.27"], p < 0.001) and log-transformed liver stiffness (adjusted beta 0.116, p < 0.001), as opposed to the NAFLD-only group, in which no cases of fibrosis were identified and no association with liver stiffness (adjusted beta 0.006, p = 0.90) was found.FLD is highly prevalent in the general population. However, not the NAFLD-only, but the MAFLD-only group was associated with fibrosis and higher liver stiffness-independent of demographic and lifestyle factors. We believe that using the MAFLD criteria will help improve the identification and treatment of patients with FLD at risk for fibrosis.
Abstract 13483: Insulin-Like Growth Factor Binding Protein 2 Overexpression Leads to Aortic Hypocontractility Through Vascular Smooth Muscle Phenotypic Switching
Authors: Thomas Slater, Alexander-Francisco Bruns, Natalie Haywood, Mohammed Abdul Waduud, Karen Hemmings, Katherine Bridge, Asjad Visnagri, Andrew Walker, Michael Drozd, Marc Bailey, Nadira Y Yuldasheva, Karen E Porter, Richard Cubbon, Mark Kearney, Stephen B Wheatcroft
Journal: Circulation (2019)

Introduction: Insulin-like growth factor binding proteins (IGFBP) exhibit multiple effects beyond regulation of IGFs. IGFBP2 is upregulated in vascular smooth muscle cells (VSMC) in human atheroscl...
Organized primary human papillomavirus–based cervical screening: A randomized healthcare policy trial
Authors: K. Miriam Elfström, Carina Eklund, Helena Lamin, Daniel Öhman, Maria Hortlund, Kristina Elfgren, Karin Sundström, Joakim Dillner
Journal: PLoS Medicine (2021)

Clinical trials in the research setting have demonstrated that primary human papillomavirus (HPV)-based screening results in greater protection against cervical cancer compared with cytology, but evidence from real-life implementation was missing. To evaluate the effectiveness of HPV-based cervical screening within a real-life screening program, the organized, population-based cervical screening program in the capital region of Sweden offered either HPV- or cytology-based screening in a randomized manner through a randomized healthcare policy (RHP).A total of 395,725 women aged 30 to 64 years that were invited for their routine cervical screening visit were randomized without blinding to either cytology-based screening with HPV triage (n = 183,309) or HPV-based screening, with cytology triage (n = 212,416 women) between September 1, 2014 and September 30, 2016 and follow-up through June 30, 2017. The main outcome was non-inferior detection rate of cervical intraepithelial neoplasia grade 2 or worse (CIN2+). Secondary outcomes included superiority in CIN2+ detection, screening attendance, and referral to histology. In total, 120,240 had a cervical screening sample on record in the study period in the HPV arm and 99,340 in the cytology arm and were followed for the outcomes of interest. In per-protocol (PP) analyses, the detection rate of CIN2+ was 1.03% (95% confidence interval (CI) 0.98 to 1.10) in the HPV arm and 0.93% (0.87 to 0.99) in the cytology arm (p for non-inferiority <0.0001; odds ratio (OR) 1.11 (95% CI 1.02 to 1.22)). There were 46 cervical cancers detected in the HPV arm (0.04% (0.03 to 0.06)) and 48 cancers detected in the cytology arm (0.05% (0.04 to 0.07)) (p for non-inferiority <0.0001; OR 0.79 (0.53 to 1.18)). Intention-to-screen (ITS) analyses found few differences. In the HPV arm, there was a modestly increased attendance after new invitations (68.56% (68.31 to 68.80) vs. 67.71% (67.43 to 67.98); OR 1.02 (1.00 to 1.03)) and increased rate of referral with completed biopsy (3.89% (3.79 to 4.00) vs. 3.53% (3.42 to 3.65); OR 1.10 (1.05 to 1.15)). The main limitations of this analysis are that only the baseline results are presented, and there was an imbalance in invitations between the study arms.In this study, we observed that a real-life RHP of primary HPV-based screening was acceptable and effective when evaluated against cytology-based screening, as indicated by comparable participation, referral, and detection rates.ClinicalTrials.gov NCT01511328.
Central Nervous System Metastases in Thymic Epithelial Tumors: A Brief Report of Real-World Insight From RYTHMIC
Authors: Jose Carlos Benitez, Marie-Ève Boucher, Eric Dansin, Mallorie Kerjouan, L Bigay-Game, Eric Pichon, François Thillays, Pierre-Emmanuel Falcoz, Svetlana Lyubimova, Youssef Oulkhouir, Fabien Calcagno, Luc Thiberville, Christelle Clément-Duchêne, Virginie Westeel, Pascale Missy, Pascal-Alexandre Thomas, Jean-Michel Maury, Thierry Molina, Nicolas Girard, Benjamin Besse
Journal: Journal of Thoracic Oncology (2021)
Clinical Implications of Inter- and Intratumor Heterogeneity of Immune Cell Markers in Lung Cancer
Authors: Wei Zhao, Bin Zhu, Amy Hutchinson, Angela Cecilia Pesatori, Dario Consonni, Neil E Caporaso, Tongwu Zhang, Difei Wang, Jianxin Shi, Maria Teresa Landi
Journal: JNCI Journal of the National Cancer Institute (2021)

Abstract Background Immune cell transcriptome signatures have been widely used to study the lung tumor microenvironment (TME). However, it is unclear to what extent the immune cell composition in the lung TME varies across histological and molecular subtypes (intertumor heterogeneity [inter-TH]) and within tumors (intratumor heterogeneity [ITH]) and whether ITH has any prognostic relevance. Methods Using RNA sequencing in 269 tumor samples from 160 lung cancer patients, we quantified the inter-TH of immune gene expression and immune cell abundance and evaluated the association of median immune cell abundance with clinical and pathological features and overall survival. In 39 tumors with 132 multiregion samples, we also analyzed the ITH of immune cell abundance in relation to overall survival using a variance-weighted multivariate Cox model not biased by the number of samples per tumor. Results Substantial inter-TH of 14 immune cell types was observed even within the same histological and molecular subtypes, but early stage tumors had higher lymphocyte infiltration across all tumor types. In multiregion samples, an unbiased estimate of low ITH of overall immune cell composition (hazard ratio [HR] = 0.40, 95% confidence interval [CI] = 0.21 to 0.78; P = .007), dendritic cells (HR = 0.24, 95% CI = 0.096 to 0.58; P = .002), and macrophages (HR = 0.50, 95% CI = 0.30 to 0.84; P = .009) was strongly associated with poor survival. The ITH of 3 markers, including CD163 and CD68 (macrophages) and CCL13 (dendritic cells), was enough to characterize the ITH of the corresponding immune cell abundances and its association with overall survival. Conclusion This study suggests that lack of immune cell diversity may facilitate tumor evasion and progression. ITH inferred from CCL13, CD163, and CD68 could be used as a prognostic tool in clinical practice.
26053 Improvement in sleep is associated with improved quality of life in adult patients with moderate-to-severe atopic dermatitis: Results from a phase 3 trial of baricitinib therapy
Authors: Peter Lio, George Han, Edward Lain, Catherine Maari, Susan Ball, Luna Sun, Amy M. DeLozier, Andrew Buchanan, Yuxin Ding, Lawrence F. Eichenfield
Journal: Journal of the American Academy of Dermatology (2021)
Stereotactic Radiotherapy for Oligoprogression in Metastatic Renal Cell Cancer Patients Receiving Tyrosine Kinase Inhibitor Therapy: A Phase 2 Prospective Multicenter Study
Authors: Patrick Cheung, Samir Patel, Scott A. North, Arjun Sahgal, William Chu, Hany Soliman, Belal Ahmad, Eric Winquist, Tamim Niazi, Francois Patenaude, Gerald Lim, Daniel Yick Chin Heng, Arbind Dubey, Piotr Czaykowski, Rebecca K.S. Wong, Anand Swaminath, Scott C. Morgan, Rupi Mangat, Sareh Keshavarzi, Georg A. Bjarnason
Journal: European Urology (2021)
26266 M89: A combination of 89% Vichy volcanic mineralizing water and hyaluronic acid applied once daily for 4 weeks improves signs and symptoms of rosacea
Authors: Jerry Tan, Julieta Spada, Cecilia Orlandi, Martina Kerscher, Maryna Anfilova, Sonya Abdulla, Anita Altmeyer, Catherine Delva, Delphine Kerob, Elena Araviiskaia
Journal: Journal of the American Academy of Dermatology (2021)
Alcohol and Gastrointestinal Cancers in Korea—Risk, Inactive Genes, and Missing Alcohol
Authors: John D. Potter
Journal: JAMA Network Open (2021)

Jung Eun Yoo, MD, PhD; Dong Wook Shin, MD, MBA, DrPH; Kyungdo Han, PhD; Dahye Kim, BS; Su-Min Jeong, MD; Hye Yeon Koo, MD; Su Jong Yu, MD, PhD; Jinsung Park, MD, PhD; Kui Son Choi, PhD
Bayesian Analysis Reporting Guidelines
Authors: John K. Kruschke
Journal: Nature Human Behaviour (2021)

Abstract Previous surveys of the literature have shown that reports of statistical analyses often lack important information, causing lack of transparency and failure of reproducibility. Editors and authors agree that guidelines for reporting should be encouraged. This Review presents a set of Bayesian analysis reporting guidelines (BARG). The BARG encompass the features of previous guidelines, while including many additional details for contemporary Bayesian analyses, with explanations. An extensive example of applying the BARG is presented. The BARG should be useful to researchers, authors, reviewers, editors, educators and students. Utilization, endorsement and promotion of the BARG may improve the quality, transparency and reproducibility of Bayesian analyses.
25742 Evaluation of the active ingredient complex of an anti-hair loss shampoo on the activation of Wnt/betacatenin pathway in human hair follicle dermal papilla cells
Authors: Ana Coutinho, Fernanda Chaves Beltrão, Fabio Sanches, Valerie Mengeaud, Camille Mas, Helene Duplan
Journal: Journal of the American Academy of Dermatology (2021)
Hepatitis B Vaccination in People Living With HIV—If at First You Don’t Succeed, Try Again
Authors: Amir M. Mohareb, Arthur Y. Kim
Journal: JAMA Network Open (2021)

Jose Ignacio Vargas, MD; Daniela Jensen, MD; Felipe Martínez, MD; Valeska Sarmiento, RN; Felipe Peirano, MD; Pedro Acuña, MD; Felipe Provoste, MD; Valentina Bustos, MD; Francisca Cornejo, MD; Antonieta Fuster; Martin Acuña, MD; Felipe Fuster, MD; Sabrina Soto; Denisse Estay, RN; Werner Jensen, MD; Rodrigo Ahumada, MD; Juan Pablo Arab, MD; Alejandro Soza, MD; Francisco Fuster, MD
25385 Secukinumab demonstrates high and sustained efficacy in nail psoriasis: Post hoc analyses from phase III studies in psoriasis and psoriatic arthritis (PsA)
Authors: Kristian Reich, Xenofon Baraliakos, Laura C. Coates, Alice B. Gottlieb, Boni Elewski, Weibin Bao, Torben Kasparek, Corine Gaillez, Effie Pournara, Maher Aassi, Chiara Perella
Journal: Journal of the American Academy of Dermatology (2021)
Clonal expansion of TCR V beta repertoires in CD8 and CD4 T cells in response to idiotype protein
Authors: Ippei Sakamaki, Kunihiro Inai, Yumie Takazawa, Hiroshi Tsutani, Takanori Ueda
Journal: Cancer Research (2004)

1287  We have investigated the cytotoxic effects of T lymphocytes activated by dendritic cells (DCs) pulsed by purified Fab portion of pathologic IgG in IM-9 myeloma cell line and reported that this truncated length antigen was a promising inducer of cytotoxic T lymphocytes (CTLs). We present here the flowcytometric characteristics of responding CTLs using a analysis of T cell receptor V beta (TCR) repertoires features . To obtain mature DCs, monocytes derived from HLA identical volunteer of target tumor were incubated for 144 h in the presence of 100 ng/ml of IL-4 and GM-CSF, respectively, pulsed with 100 μg of the Fab antigen for additional 24 h. CTLs obtained by co-cultiring for 2 weeks with the induced mature DCs were analyzed the clonality of T cell receptor V beta (TCR) repertoires features by flow cytometry (FACs Calibar, Becton Dickinson) and the cytotoxic response against IM-9 cells by LDH releasing assay kit (Promega). Treatment of the monocyte-derived DCs by the idiotypic antigens oligoclonally increased the percentage of TCRs in CD8 T cells and was revealed cytotoxic reaction against the HLA identical targets. Interestingly, CD4 cells also showed clonal skewing of TCRs. Although similar skewing distribution was also shown to several repertoires in CD8 as well as CD4 T cells by non-identical peptide stimulation, cytotoxic response was abrogated. On the other hand, education of T cells by DCs alone revealed neither upregulation of TCRs nor injury of target cells. These finding suggest that CTLs were clonally induced with the restriction of HLA identity between CTLs and the target cells, and that the induction of CTLs may have need of the cooperative expansion of CD4 T cells.
Device Therapy in Chronic Heart Failure
Authors: Marat Fudim, William T. Abraham, Ralph Stephan von Bardeleben, JoAnn Lindenfeld, Piotr P. Ponikowski, Husam M. Salah, Muhammad Shahzeb Khan, Horst Sievert, Gregg W. Stone, Stefan D. Anker, Javed Butler
Journal: Journal of the American College of Cardiology (2021)
Association Between Neighborhood Disadvantage and Functional Well-being in Community-Living Older Persons
Authors: Thomas M. Gill, Emma X. Zang, Terrence E. Murphy, Linda Leo-Summers, Evelyne A. Gahbauer, Natalia Festa, Jason R. Falvey, Ling Han
Journal: JAMA Internal Medicine (2021)

Neighborhood disadvantage is a novel social determinant of health that could adversely affect the functional well-being of older persons. Deficiencies in resource-poor environments can potentially be addressed through social and public health interventions.To evaluate whether estimates of active and disabled life expectancy differ on the basis of neighborhood disadvantage after accounting for individual-level socioeconomic characteristics and other prognostic factors.This prospective longitudinal cohort study included 754 nondisabled community-living persons, aged 70 years or older, who were members of the Precipitating Events Project in south central Connecticut from March 1998 to June 2020.Disability in 4 essential activities of daily living (bathing, dressing, walking, and transferring) was assessed each month. Scores on the Area Deprivation Index, a census-based socioeconomic measure with 17 education, employment, housing quality, and poverty indicators, were obtained through linkages with the 2000 Neighborhood Atlas. Area Deprivation Index scores were dichotomized at the 80th state percentile to distinguish neighborhoods that were disadvantaged (81-100) from those that were not (1-80).Among the 754 participants, the mean (SD) age was 78.4 (5.3) years, and 487 (64.6%) were female. Within 5-year age increments from 70 to 90, active life expectancy was consistently lower in participants from neighborhoods that were disadvantaged vs not disadvantaged, and these differences persisted and remained statistically significant after adjustment for individual-level race and ethnicity, education, income, and other prognostic factors. At age 70 years, adjusted estimates (95% CI) for active life expectancy (in years) were 12.3 (11.5-13.1) in the disadvantaged group and 14.2 (13.5-14.7) in the nondisadvantaged group. At each age, participants from disadvantaged neighborhoods spent a greater percentage of their projected remaining life disabled, relative to those from nondisadvantaged neighborhoods, with adjusted values (SE) ranging from 17.7 (0.8) vs 15.3 (0.5) at age 70 years to 55.0 (1.7) vs 48.1 (1.3) at age 90 years.In this prospective longitudinal cohort study, living in a disadvantaged neighborhood was associated with lower active life expectancy and a greater percentage of projected remaining life with disability. By addressing deficiencies in resource-poor environments, new or expanded social and public health initiatives have the potential to improve the functional well-being of community-living older persons and, in turn, reduce health disparities in the US.
Phosphorylation of androgen receptor by mTORC1 promotes liver steatosis and tumorigenesis
Authors: Qian‐Nan Ren, Hong Zhang, Chao‐Yue Sun, Yu‐Feng Zhou, Xue‐Feng Yang, Jian‐Wu Long, Xiao‐Xing Li, Shi‐Juan Mai, Mei‐Yin Zhang, Hui‐Zhong Zhang, Hai‐Qiang Mai, Min‐Shan Chen, X.F. Steven Zheng, Hui‐Yun Wang
Journal: Hepatology (2021)

Abstract Background and Aims Androgen receptor (AR) has been reported to play an important role in the development and progression of man’s prostate cancer. Hepatocellular carcinoma (HCC) is also male‐dominant, but the role of AR in HCC remains poorly understood. Mechanistic target of rapamycin complex 1 (mTORC1) also has been reported to be highly activated in HCC. In this study, we aimed to explore the role of AR phosphorylation and its relationship with mTORC1 in hepatocarcinogenesis. Approach and Results In vitro experiment, we observed that mTORC1 interacts with hepatic AR and phosphorylates it at S96 in response to nutrient and mitogenic stimuli in HCC cells. S96 phosphorylation promotes the stability, nuclear localization, and transcriptional activity of AR, which enhances de novo lipogenesis and proliferation in hepatocytes and induces liver steatosis and hepatocarcinogenesis in mice independently and cooperatively with androgen. Furthermore, high AR S96 phosphorylation is observed in human liver steatotic and HCC tissues and is associated with overall survival and disease‐free survival, which has been proven as an independent survival predictor for patients with HCC. Conclusions AR S96 phosphorylation by mTORC1 drives liver steatosis and HCC development and progression independently and cooperatively with androgen, which not only explains why HCC is man‐biased but also provides a target molecule for prevention and treatment of HCC and a potential survival predictor in patients with HCC.
Comments on: “Fine-needle aspiration of pancreatic cystic lesions: a randomized study with long-term follow-up comparing standard and flexible needles”
Authors: Ayushi Jain, Somashekar G. Krishna
Journal: Endoscopy (2021)

See also: Reply to Krishna and JainEndoscopy 2021; 53(09): 988-988DOI: 10.1055/a-1473-5567 See also: Fine-needle aspiration of pancreatic cystic lesions: a randomized study with long-term follow-up comparing standard and flexible needles Endoscopy 2021; 53(11): 1132-1140DOI: 10.1055/a-1311-9927
Association of Remote vs In-Person Benefit Delivery With WIC Participation During the COVID-19 Pandemic
Authors: Aditi Vasan, Chén C. Kenyon, Christina A. Roberto, Alexander G. Fiks, Atheendar S. Venkataramani
Journal: JAMA (2021)

This study assesses whether participation in the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) differed before and during the COVID-19 pandemic in states with offline vs online electronic benefits transfer debit cards.
Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage
Authors: Sean K. Bedingfield, Juan M. Colazo, Fang Yu, Danielle D. Liu, Meredith A. Jackson, Lauren E. Himmel, Hongsik Cho, Leslie J. Crofford, Karen A. Hasty, Craig L. Duvall
Journal: Nature Biomedical Engineering (2021)
Quantifying the phase separation property of chromatin-associated proteins under physiological conditions using an anti-1,6-hexanediol index
Authors: Minglei Shi, Kaiqiang You, Taoyu Chen, Chao Hou, Zhengyu Liang, Mingwei Liu, Jifeng Wang, Taotao Wei, Jun Qin, Yang Chen, Michael Q. Zhang, Tingting Li
Journal: Genome biology (2021)

Liquid-liquid phase separation (LLPS) is an important organizing principle for biomolecular condensation and chromosome compartmentalization. However, while many proteins have been reported to undergo LLPS, quantitative and global analysis of chromatin LLPS property remains absent.Here, by combining chromatin-associated protein pull-down, quantitative proteomics and 1,6-hexanediol (1,6-HD) treatment, we develop Hi-MS and define an anti-1,6-HD index of chromatin-associated proteins (AICAP) to quantify 1,6-HD sensitivity of chromatin-associated proteins under physiological conditions. Compared with known physicochemical properties involved in phase separation, we find that proteins with lower AICAP are associated with higher content of disordered regions, higher hydrophobic residue preference, higher mobility and higher predicted LLPS potential. We also construct BL-Hi-C libraries following 1,6-HD treatment to study the sensitivity of chromatin conformation to 1,6-HD treatment. We find that the active chromatin and high-order structures, as well as the proteins enriched in corresponding regions, are more sensitive to 1,6-HD treatment.Our work provides a global quantitative measurement of LLPS properties of chromatin-associated proteins and higher-order chromatin structure. Hi-MS and AICAP data provide an experimental tool and quantitative resources valuable for future studies of biomolecular condensates.
Nine in 10 female doctors in UK have experienced sexism at work, says BMA
Authors: Abi Rimmer
Journal: BMJ (2021)

Most doctors think that sexism is an issue in medicine, the BMA has said.

In a report published on 26 August the association set out the results of a survey of 2458 NHS doctors that it conducted in April 2021.1

Of the 2018 women (82%) who responded to the survey, 91% (1836) said that they had experienced sexism at work in the past two years.

Nearly two thirds of women (61%; 1230) had felt discouraged to work in a particular specialty because of their gender, and 70% (861) believed that their clinical ability had been doubted or undervalued because of their gender.

Over half of the women (56%; 688) also said that they had received unwanted verbal comments relating to their gender, and a third (31%; 381) said that they had experienced unwanted physical conduct …
胃における細菌誘導グループ2自然リンパ細胞はIgA誘導を介して免疫防御を提供する【JST・京大機械翻訳】
Authors: Satoh-Takayama Naoko, Kato Tamotsu, Motomura Yasutaka, Kageyama Tomoko, Taguchi-Atarashi Naoko, Kinoshita-Daitoku Ryo, Kuroda Eisuke, P Di Santo James, Mimuro Hitomi, Moro Kazuyo, Ohno Hiroshi
Journal: Immunity (2020)
O-11 Monitoring molecular residual disease by circulating tumor DNA in resectable colorectal cancer: Molecular subgroup analyses of a prospective observational study GALAXY in CIRCULATE-Japan
Authors: H. Shirasu, H. Taniguchi, J. Watanabe, M. Kotaka, K. Yamazaki, K. Hirata, M. Yokota, Y. Emi, M. Ikenaga, K. Kato, N. Akazawa, T. Yamaguchi, M. Ikeda, A. Aleshin, D. Kotani, S. Mishima, H. Yukami, E. Oki, I. Takemasa, T. Kato, Y. Nakamura, T. Yoshino
Journal: Annals of Oncology (2021)