tbuckley/cabot-search huggingface dataset:
Prospective diagnosis of d-transposition of the great arteries in neonates by subxiphoid, two-dimensional echocardiography.
Authors: F ZBierman, R GWilliams
Journal: Circulation (1979)

Subxiphoid, two-dimensional echocardiograms (S2DE) were performed and interpreted before diagnostic cardiac catheterization on 59 neonates who weighed 1.3--6.0 kg (median 3.3 kg) and were 1--35 days old (median 4.5 days). The echocardiographic studies were successfully performed on 58 of 59 infants. Using appropriate longitudinal and transverse projections, S2DE permitted simultaneous visualization of the branch pulmonary arteries, proximal thoracic aorta and ventriculoarterial attachments. D-transposition of the great arteries was correctly predicted in all 16 infants with levocardia, situs solitus and atrioventricular concordance. In these patients, the standard left ventricular longitudinal projection demonstrated the bifurcating main pulmonary artery attached to the posterior ventricle; the transverse projection displayed the relationship of the proximal thoracic aorta to the anterior ventricle. The broad acoustical window using the subxiphoid approach in conjunction with a high-frequency focused tran...
Feasibility/eligibility of T‐wave alternans testing in patients with heart failure: should we rethink our current modus operandi?: reply
Authors: Colette E. Jackson, Rachel C. Myles, Ioannis K. Tsorlalis, Jonathan R. Dalzell, Richard J. Spooner, John R. Rodgers, Vladimir Bezlyak, Nicola Greenlaw, Ian Ford, Stuart M. Cobbe, Mark C. Petrie, John J.V. McMurray
Journal: European Journal of Heart Failure (2012)
Selinexor in Combination with R-CHOP for Frontline Treatment of Non-Hodgkin Lymphoma: Results of a Phase I Study
Authors: Erlene K. Seymour, Husain Yar Khan, Yiwei Li, Mahmoud Chaker, Irfana Muqbil, Amro Aboukameel, Radhakrishanan Ramchandren, Christiane Houde, Golbon Sterbis, Jay Yang, Divaya Bhutani, Silvana Pregja, Kathy Reichel, Amy Huddlestun, Colleen Neveux, Kelly Corona, Yosef Landesman, Jatin Shah, Michael Kauffman, Sharon Shacham, Ramzi M. Mohammad, Asfar S. Azmi, Jeffrey A. Zonder
Journal: Clinical Cancer Research (2021)

The nuclear exporter protein exportin-1 (XPO1) is overexpressed in non-Hodgkin lymphoma (NHL) and correlates with poor prognosis. We evaluated enhancing R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) activity in NHL by targeted inhibition of XPO1 using the selective inhibitor of nuclear export (SINE) compounds.We evaluated the antitumor activity of SINE compounds in combination with CHO chemotherapy in vitro and in vivo. Newly diagnosed NHL patients in a phase I dose-escalation study received R-CHOP for 6 cycles with weekly selinexor (60, 80, and 100 mg), then selinexor maintenance therapy for one year. RT-PCR, Western blotting, and RNA sequencing were performed on patient blood samples.SINE compounds synergized with CHO in vitro in NHL cell lines and in vivo in our murine xenograft model. In our phase I study, selinexor was dosed at 60 mg (n = 6) and 80 mg (n = 6). The most common adverse events (AE) among 12 patients were fatigue (67%) and nausea (100%). Grade 3-4 AEs were infrequent. Ten evaluable patients had an overall response rate of 100% and complete remission rate of 90% with sustained remissions (median follow-up: 476 days). Maximally tolerated dose was not reached; however, the recommended phase II dose was 60 mg selinexor weekly after evaluating tolerability and discontinuation rates for each dose cohort. Analysis of patient blood samples revealed downregulation of XPO1 and several prosurvival markers.SINE compounds enhance the activity of CHO in vitro and in vivo. Selinexor in combination with R-CHOP was generally well tolerated and showed encouraging efficacy in NHL (NCT03147885).
Role of ATP-sensitive K+ channel on ECG ST segment elevation during a bout of myocardial ischemia. A study on epicardial mapping in dogs.
Authors: IKubota, MYamaki, TShibata, EIkeno, YHosoya, HTomoike
Journal: Circulation (1993)

BACKGROUNDATP-sensitive K+ channels are activated when the myocardium becomes ischemic. However, the role of the ATP-sensitive K+ current in the emergence of ECG ST changes during ischemia remained unclarified.METHODS AND RESULTSThe left anterior descending coronary artery (LAD) was cannulated and perfused with arterial blood from the carotid artery through a bypass tube in 8 anesthetized, open-chest dogs. An array of 60 unipolar electrodes mounted on a sock was used to record epicardial electrograms of the whole heart. Pinacidil (10 micrograms.kg-1 x min-1), an ATP-sensitive K+ channel opener, was infused into the bypass tube for 2 minutes, and the electrograms were recorded before and after the infusion. The elevation of the ST segment and the increase of QRST area were observed spatially over the LAD-perfused region. At the electrode showing the largest ST segment elevation, the activation recovery interval, an index of action potential duration, was shortened from 202 +/- 9 to 111 +/- 18 milliseconds ...
Cardioreparative effects of lisinopril in rats with genetic hypertension and left ventricular hypertrophy.
Authors: C GBrilla, J SJanicki, K TWeber
Journal: Circulation (1991)

BACKGROUNDIn genetic and acquired hypertension, a structural remodeling of the nonmyocyte compartment of the myocardium, including the accumulation of fibrillar collagen within the interstitium and adventitia of intramyocardial coronary arteries and a medial thickening of these vessels, represents a determinant of pathological hypertrophy that leads to ventricular dysfunction.METHODS AND RESULTSTo evaluate the benefit of angiotensin converting enzyme inhibition in reversing this interstitial and vascular remodeling in the rat with genetic spontaneous hypertension (SHR) and established left ventricular hypertrophy (LVH), we treated 14-week-old male SHR with oral lisinopril (average dose, 15 mg/kg/day) for 12 weeks. Myocardial stiffness and coronary vascular reserve to adenosine (800 micrograms/min) were examined in the isolated heart; myocardial collagen and intramural coronary artery architecture were analyzed morphometrically. In lisinopril-treated SHR compared with 14-week-old baseline or 26-week-old un...
Neuropeptide control of rat gastric mucosal blood flow. Increase by calcitonin gene-related peptide and vasoactive intestinal polypeptide, but not substance P and neurokinin A.
Authors: PHolzer, P HGuth
Journal: Circulation Research (1991)

Submucosal blood vessels of the mammalian stomach are densely innervated by neurons containing calcitonin gene-related peptide (CGRP), substance P, neurokinin A, and vasoactive intestinal polypeptide (VIP). Because all these peptides are vasodilators in certain vascular beds, we tested the hypothesis that rat alpha-CGRP, rat VIP, substance P, and neurokinin A are candidate mediators of noncholinergic vasodilator neurons in the gastric mucosa and submucosa. The experiments were performed on urethane-anesthetized Sprague-Dawley rats. Gastric mucosal blood flow (GMBF) was measured by the hydrogen gas clearance technique, and the peptides were infused close arterially to the stomach via a catheter inserted retrogradely in the splenic artery. Basal GMBF was in the range of 35-50 ml/min/100 g. Infusion of rat alpha-CGRP (15 and 75 pmol/min) significantly increased GMBF in a dose-dependent manner, whereas mean arterial blood pressure was significantly lowered only by the higher dose of CGRP. Substance P (125 and...
The Dickinson W. Richards lecture. New concepts in assessing cardiovascular function.
Authors: KWasserman
Journal: Circulation (1988)

The primary role of the heart is to provide energy for the circulatory transport of oxygen (O2) to cells at rates commensurate with their metabolic activity. At rest, even a sick heart may be capable of transporting O2 adequately. But during exercise, the increase in O2 required by muscle cells demands that their blood flow be increased. The supply of O2 needed to meet the O2 requirement for muscle mitochondrial high-energy phosphate generation during exercise is a critical function of the circulation. Thus, the adequacy of cardiovascular function can be estimated, noninvasively, from the pattern of O2 uptake in response to an exercise stimulus. While arterial O2 tension (PaO2) is dependent on pulmonary function (except for intracardiac right-to-left shunt), the mass transfer of O2 (VO2) between the cells and lungs depends on pulmonary blood flow (i.e., cardiac output) and O2 concentration difference between the pulmonary arterial and pulmonary venous blood, C(a-v)O2 (Fick principle). Thus, VO2 in the f...
Interferon-gamma inhibits arterial stenosis after injury.
Authors: G KHansson, JHolm
Journal: Circulation (1991)

BACKGROUNDArterial injury initiates a proliferative response among the smooth muscle cells of the artery. This leads to the formation of a thickened intima that may reduce the diameter of the arterial lumen. Such intimal lesions often develop after vascular surgery and angioplastic procedures. Previous cell culture studies have shown that the lymphokine, interferon-gamma (gIFN), inhibits smooth muscle cell proliferation.METHODS AND RESULTSWe therefore tested whether administration of exogenous gIFN could inhibit the development of intimal lesions. Rat carotid arteries were denuded with a balloon catheter, resulting in the formation of a standardized intimal lesion. The animals were then treated with recombinant rat gIFN at 200,000 units (approximately 400,000 units or 100 micrograms/kg body wt) administered parenterally once daily for 7 days. Autoradiographic analysis of 3H-thymidine incorporation revealed that gIFN reduced the early smooth muscle replication by approximately 75%. gIFN treatment for 1 wee...
Effects of different training intensities on 24-hour blood pressure in hypertensive subjects.
Authors: MMarceau, NKouamé, YLacourcière, JCléroux
Journal: Circulation (1993)

BACKGROUNDIt is generally accepted that physical training decreases blood pressure in hypertensive subjects, but the importance of training intensity has not been established. This study compared the effects of endurance training at different intensities on ambulatory blood pressure and on blood pressure load (percentage of readings above 140/90 and 120/80 mm Hg during the waking and sleeping periods, respectively).METHODS AND RESULTSPreviously sedentary subjects with mild to moderate hypertension were evaluated in a crossover fashion according to a Latin square after a sedentary control period and after training at low and at moderate intensity corresponding to 50% and 70% of maximal oxygen uptake, respectively. Each period lasted 10 weeks. After training at moderate intensity, a higher maximal oxygen uptake was found compared with sedentary values but not after training at low intensity. Both training intensities exerted a similar antihypertensive effect of about 5 mm Hg for systolic and diastolic 24-ho...
Abnormal left ventricular contraction pattern in the systolic click-late systolic murmur syndrome.
Authors: D GMathey, P RDecoodt, H NAllen, H JSwan
Journal: Circulation (1977)

A contraction abnormality of the left ventricle has previously been described in patients with systolic click-late systolic murmur syndrome. To determine if the contraction abnormality is present in the preprolapse period, LV dimensions and the instantaneous velocity of circumferential fiber shortening (VCF) were studied in 18 patients with the mitral valve prolapse and 16 normal subjects using computer analysis of echocardiograms. VCF attained its maximum (max VCF) during the preprolapse period an average of 94 msec before the mid-systolic click. Max VCF was significantly reduced in patients with mitral valve prolapse (2.06 vs 2.55 circ/sec in normal subjects, P less than 0.001). Despite the reduction in max VCF, no difference in the extent and percentage of diameter shortening was found between patients and normal subjects. This discrepancy is explained by a sustained rate of mid-to-late systolic diameter shortening in the presence of mitral valve prolapse as manifested by a typical VCF profile (P less ...
Recent Advances: Respiratory medicine
Authors: R M du Bois
Journal: BMJ (1995)

female genital mutilation is usually circulated among a closely knit group of individuals, their intentions laudable but their influence limited.The vast majority of health professionals in this country still think of female genital mutilation as a female version of male circumcision-rather like comparing rape with masturbation. Educate families firstFemale genital mutilation affects girls, often too young or scared to fend for themselves, who are almost invariably subjected to vigorous social and family pressure.It is those families that must be educated first, with discretion and sensitivity, and preferably by women from within their own communities.The only way that this harmful and mindless practice will be eradicated-both here and abroad-will be when parents wish to provide their daughters with the freedom, status, and physical safety that they deserve.For this to happen, women within those communities, many of whom will have been subjected to female genital mutilation themselves, must be empowered to speak out for what they want rather than that which they have come to expect.Legislation against female genital mutilation may well have contributed to the practice going "under- ground" in this country, but it has not made it disappear.Declarations, discussion, and increasing media interest are making a valuable contribution to the understanding of female genital mutilation, but it will be those who are affected most who will eventually make the choice to eradicate the mutilation on our doorsteps.
Endoscopy Of Congenital Partial High Intestinal Obstruction: Improving Diagnostic Accuracy
Authors: A Sautin, Y Kaminskaya, K Marakhouski
Journal: Endoscopy (2021)

Aims Endoscopy allows to determine the cause and localization of congenital high partial intestinal obstruction (CPHIO), but endoscopic picture not always correlates with the surgical findings. Endoscopy in newborns is a technically complicated due to the limited facilities of endoscopic equipment and special patients condition. According to endoscopy, the causes of CPHIO can be assigned to intrinsic or extrinsic compression.
Genetic Activation and Therapeutic Targeting of PIM1 in T-Cell Acute Lymphoblastic Leukemia/Lymphoma
Authors: Renate De Smedt, Sofie Peirs, Julie Morscio, Juliette Roels, Steven Goossens, Aurore Touzart, Anne Uyttebroeck, Nadine Van Roy, Tim Lammens, Lara Mussolin, Elizabeth Macyntire, Peter Vandenberghe, Pieter Van Vlierberghe
Journal: Blood (2017)
Torsion of Normal Fallopian Tube
Authors: R. de Soldenhoff
Journal: BMJ (1949)

BRfAfsHAL 263 or fever he must discontinue the drug and report to his doctor.The same procedure might be applied in the prolonged sulphonamide administration employed in rheuma- tism prophylaxis.For other cases of sulphonamide administration, limitation of the period of treatment to a week or ten days is probably the best method of prophylaxis, and seems to have almost eliminated agranulocytosis due to this group of drugs.Amidopyrine agranulocytosis is readily avoided, as this drug is unnecessary and should no longer be used. SummaryNo evidence has been found that serial leucocyte counts during the administration of agranulocytosis-producing drugs either prevent agranulocytosis or reduce case mortality.The reason for this failure is found in the bone marrow, where the condition can become fully established before the peripheral blood gives any warning.Reliance on leucocyte counts is undesirable, as they may give rise to a misguided sense of security which may prevent the adoption of more useful measures.9Leucocyte counts for purposes of prophylaxis also constitute a waste of time in clinical pathological departments of hos- pitals, and may mislead clinicians into stopping the administra- tion prematurely, so unnecessarily depriving patients of the benefits of treatment.Other methods of dealing with drug agranulocytosis are briefly mentioned.
Beta-adrenergic supersensitivity of the transplanted human heart is presynaptic in origin.
Authors: E MGilbert, C CEiswirth, P CMealey, PLarrabee, C MHerrick, M RBristow
Journal: Circulation (1989)

An increase in cardiac beta-adrenergic sensitivity or beta-receptor density or both has been described in several animal species after denervating the heart. The transplanted human heart is also denervated and, therefore, may exhibit supersensitivity to beta-adrenergic agonists and an increase in beta-adrenergic receptor density. In 16 patients examined 1-3 months after orthotopic cardiac transplantation, beta-adrenergic receptor density measured by [125I]iodocyanopindolol binding in endomyocardial biopsy specimens was not significantly different in transplant recipients compared with normal controls (transplant = 1,429 +/- 199, control = 1,728 +/- 263 fmol/g wet wt; p = NS). However, when normalized to Lowry protein, the [125I]iodocyanopindolol in beta-adrenergic receptor density in biopsy tissue from transplant recipients was significantly lower than in tissue from controls (transplant = 58.1 +/- 6.2, control = 93.5 +/- 13.4 fmol/g Lowry protein; p = 0.011). Atrial sinus node activity of the denervated ...
Increased arterial pressure variability after arterial baroreceptor denervation in fetal lambs.
Authors: R WYardley, GBowes, MWilkinson, J PCannata, J EMaloney, B CRitchie, A MWalker
Journal: Circulation Research (1983)

Baroreceptor reflexes can be demonstrated during fetal life, but whether baroreceptors normally regulate fetal arterial pressure is unknown. This problem was addressed directly by measuring arterial pressure and analyzing its variation in eight unanesthetized fetal lambs throughout the last third of gestation, and comparing these data with similar measurements made in seven fetal lambs with denervated arterial baroreceptors. Measurements were made at 5-minute intervals over 24 hours in a total of thirty-three experiments. The coefficient of variation of mean arterial pressure (standard deviation of mean arterial pressure/mean value of mean arterial pressure) expressed as a percentage was used as an index of blood pressure variability. Coefficients averaged 7.0% in intact lambs and 12.1% in barodenervated lambs (P less than 0.001), signifying considerably increased variability of mean arterial pressure after barodenervation. Mean arterial pressure averaged over 24 hours was not different between the two gr...
Effect of nitroglycerin on aortic impedance, diameter, and pulse-wave velocity.
Authors: T WLatson, W CHunter, NKatoh, KSagawa
Journal: Circulation Research (1988)

The effects of an intravenous infusion of 1 microgram/kg/min nitroglycerin were studied on systemic arterial properties in nine acutely instrumented dogs. Aortic impedance and pulse-wave velocity were calculated from measured pressure and flow signals collected during random ventricular pacing. Central aortic diameter was simultaneously determined with ultrasonic dimension crystals. Mean blood pressure was maintained constant to avoid the confounding effects of passive, pressure-induced changes in vascular properties. Nitroglycerin both reduced the amplitude of peripheral vascular reflections and delayed the return of these reflections to the aortic root. This reflection delay was manifested as a consistent leftward shift in both impedance modulus and phase. The magnitude of this reflection delay could not be entirely accounted for on the basis of the measured changes in average pulse-wave velocity along the aorta.
TCTAP C-014 Spontaneous Coronary Artery Dissection Complicating ST Elevation Myocardial Infarction in Young Women: To Stent or Not To Stent
Authors: Safir Sungkar, Amir Aziz Alkatiri, Nanda Iryuza, Doni Firman
Journal: Journal of the American College of Cardiology (2021)
Clinical and angiographic results of transluminal extraction coronary atherectomy in saphenous vein bypass grafts.
Authors: R DSafian, C LGrines, M AMay, ALichtenberg, NJuran, T LSchreiber, GPavlides, T BMeany, VSavas, W WO'Neill
Journal: Circulation (1994)

BACKGROUNDTransluminal extraction coronary (TEC) atherectomy is a relatively new device that has recently been approved by the Food and Drug Administration. Because of its ability to aspirate clot and atheromatous material, TEC atherectomy may be useful in patients with stenoses in saphenous vein bypass grafts.METHODS AND RESULTSTEC atherectomy was performed on 158 saphenous vein graft lesions in 146 consecutive patients with a mean age of 65 +/- 8 years (78% men). Clinical indications for atherectomy included stable angina (37%), unstable angina (54%), and postinfarction angina after recent (< 1 month) myocardial infarction (8%). Patients with acute myocardial infarction and target vessels < 2 mm in diameter were excluded. The mean age of the bypass graft was 8.3 +/- 3.0 years, and 17% were diffusely diseased and degenerated. Complex lesion morphology included total occlusion (6%), eccentricity (64%), ulceration (18%), and thrombus (28%). The TEC atherectomy cutter was successfully advanced through 144 l...
(Don’t) Let the Mid-Gut Bleed - Impact of Enteroscopy
Authors: L Scaramella, M Topa, GE Tontini, A Rimondi, E Rondonotti, R Penagini, M Vecchi, L Elli
Journal: Endoscopy (2021)

Aims Suspected small bowel bleeding (SSBB) is the main indication for enteroscopy. SSBB studies are characterized by a reduced sample size, rarely including data from both enteroscopic techniques. We assessed in a large cohort of SSBB patients the impact of videocapsule (VCE) and double balloon enteroscopy (DBE).
Acquired platelet GPVI receptor dysfunction in critically ill patients with sepsis
Authors: Lukas J. Weiss, Georgi Manukjan, Annerose Pflug, Nadine Winter, Mathis Weigel, Nils Nagler, Markus Kredel, Thiên-Trí Lâm, Bernhard Nieswandt, Dirk Weismann, Harald Schulze
Journal: Blood (2021)
Energy turnover and mechanical properties of resting and contracting aortas and portal veins from normotensive and spontaneously hypertensive rats.
Authors: AArner, PHellstrand
Journal: Circulation Research (1981)

Aortas and portal veins from spontaneously hypertensive rats (SHR) and matched normotensive Wistar-Kyoto rats (WKY) were studied with respect to their energy turnover and mechanical properties. Relaxed aortas fom SHR 16--17 weeks and 20--25 weeks of age were stiffer, had smaller circumference, and greater maximal active wall tension compared to WKY aortas. Active stress (forced/areas) was not different. Passive and active length-force relations of portal veins from 16 to 17-week-old SHR and WKY were not different. O2 consumption (JO2) and lactate production (JLA) were studied in aortas and portal veins from 20- to 25-week-old rats. In relaxed aortas, JO2 was 0.63 +/- 0.03 (n = 1) and 0.54 +/- 0.03 (n = 10) mu mol/min per g dry wt in SHR and WKY, respectively (P less than 0.05). On activation by high-K+ solution, JO2 increased with tension in a similar way in both groups. In contrast, JLA, about 0.85 mu mol/min per g, did not differ, and decreased with tension development. JO2 of relaxed portal veins, abou...