tbuckley/cabot-search huggingface dataset:
2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Recommendations for Nonpharmacologic Therapies, Medication Monitoring, Immunizations, and Imaging
Authors: Karen B. Onel, Daniel B. Horton, Daniel J. Lovell, Susan Shenoi, Carlos A. Cuello, Sheila T. Angeles‐Han, Mara L. Becker, Randy Q. Cron, Brian M. Feldman, Polly J. Ferguson, Harry Gewanter, Jaime Guzman, Yukiko Kimura, Tzielan Lee, Katherine Murphy, Peter A. Nigrovic, Michael J. Ombrello, C. Egla Rabinovich, Melissa Tesher, Marinka Twilt, Marisa Klein‐Gitelman, Fatima Barbar‐Smiley, Ashley M. Cooper, Barbara Edelheit, Miriah Gillispie‐Taylor, Kimberly Hays, Melissa L. Mannion, Rosemary Peterson, Elaine Flanagan, Nadine Saad, Nancy Sullivan, Ann Marie Szymanski, Rebecca Trachtman, Marat Turgunbaev, Keila Veiga, Amy S. Turner, James T. Reston
Journal: Arthritis & Rheumatology (2022)

Objective To provide recommendations for the management of juvenile idiopathic arthritis (JIA) with a focus on nonpharmacologic therapies, medication monitoring, immunizations, and imaging, irrespective of JIA phenotype. Methods We developed clinically relevant Patient/Population, Intervention, Comparison, and Outcomes questions. After conducting a systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation approach was used to rate the quality of evidence (high, moderate, low, or very low). A Voting Panel including clinicians and patients/caregivers achieved consensus on the direction (for or against) and strength (strong or conditional) of recommendations. Results Recommendations in this guideline include the use of physical therapy and occupational therapy interventions; a healthy, well‐balanced, age‐appropriate diet; specific laboratory monitoring for medications; widespread use of immunizations; and shared decision‐making with patients/caregivers. Disease management for all patients with JIA is addressed with respect to nonpharmacologic therapies, medication monitoring, immunizations, and imaging. Evidence for all recommendations was graded as low or very low in quality. For that reason, more than half of the recommendations are conditional. Conclusion This clinical practice guideline complements the 2019 American College of Rheumatology JIA and uveitis guidelines, which addressed polyarthritis, sacroiliitis, enthesitis, and uveitis, and a concurrent 2021 guideline on oligoarthritis, temporomandibular arthritis, and systemic JIA. It serves as a tool to support clinicians, patients, and caregivers in decision‐making. The recommendations take into consideration the severity of both articular and nonarticular manifestations as well as patient quality of life. Although evidence is generally low quality and many recommendations are conditional, the inclusion of caregivers and patients in the decision‐making process strengthens the relevance and applicability of the guideline. It is important to remember that these are recommendations. Clinical decisions, as always, should be made by the treating clinician and patient/caregiver.
STUDIES ON A-AVITAMINOSIS IN CHICKENS
Authors: Oskar Seifried
Journal: The Journal of Experimental Medicine (1930)

When fowls are placed on a diet lacking in vitamin A lesions appear in the upper alimentary tract which are confined largely to the mucous glands and their ducts. Histologically it is shown that the original epithelium becomes replaced by a stratified squamous keratinizing epithelium and that secondary infections are relatively common. The ducts of the glands may be blocked leading to distention with secretions and necrotic materials. These lesions macroscopically resemble very closely certain stages of fowl-pox and the two conditions can be separated only by histological examination. It is pointed out that these lesions produced by a lack of vitamin A may enable bacteria and other viruses to enter the body.
On Diseased Conditions of the Knee-Joint
Authors: W. P. Swain
Journal: BMJ (1866)

Under the care of Mr. Kempe, of Exeter.Scrofulous disease of the knee-joint, arising from a blow some years since.His health was very much impaired, rendering some operation im- perative.Although the case was not the most suit- able one for resection, the friends preferred its trial to amputation.The joint was reseeted under chloroform.The articular surfaces of the femur and tibia, with the whole of the patella, were removed, although the latter bone was not implicated in the disease.No vessels required ligaturing.The boy was much exhausted by the operation and the effects of the chloroform.The H-incision was made.No untoward symptoms followed; the healing process, however, was very slow; several sinuses
Selected Works of Henry Clapp Sherman, Mitchill Professor Emeritus of Chemistry, Columbia University, New York
Journal: JAMA (1949)

This book is a tribute to a great and inspiring teacher and to a great research worker who continues to contribute importantly to the world's knowledge of nutrition. It consists of over one hundred reprintings of original articles by Dr. Sherman published from 1895 to the present. Most of the papers included are reports of original research, while a few are addresses and reviews. Also included are biographic notes and a complete list of Dr. Sherman's papers and books. All this material was assembled by a committee of students and co-workers from Columbia University, who express their appreciation of Dr. Sherman as a teacher and associate in a foreword. In a section entitled "Looking Forward in Nutrition," which was written especially for this volume, Dr. Sherman states that even though further research will add much to our knowledge of nutrition the application of our present knowledge could result in a
Factors associated with hepatic steatosis in adult Greek subjects with type 2 diabetes mellitus
Authors: Angeliki Meritsi, Emanuel Manesis, Marina Noutsou, Panagiotis Koussis, Stamatia Rapti, Dimitra Latsou, Ioannis Tsorlalis, Eustathios Tsitsopoulos, Hariklia Moshoyianni, Spilios Manolakopoulos, Dimitrios Pektasides, Anastasia Thanopoulou
Journal: Metabolism (2022)
Medicolegal.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leaves from My Diary during the Ashantee War
Authors: A. A. Gore
Journal: BMJ (1874)

IV.-EN ROUTE.WN-E bad adieu to the low alluvial shores of the Gambia on September 2nd, a sultry close morning, 8o and 82 deg. in the cabin, port open, at 7 A. M. A few mosquitoes had already made their appearance; and the deck was crowded with Sierra Leone women, returning to Freetown after having disposed of their baskets of Cola nuts to Mandingo traders, w ho pay a high price for this much coveted fruit, chewing it in their long journeys, a natural instinict leading them to its use.The purser and the " ladies of the period" were in angry dispute on the subject of the fare-the latter vowing that they could only afford a moiety of the amount, while the former stood upon his rights.Silence at last indi- cated that this grand palaver had been amicably settled.Shortly be- fore, a number of African gentlemen had come on board to wish one of their friends adieu, and were scarcely less troublesome below, where Moselle corks were flying about in all directions.How pleasant they must have all felt next morning!We had had an addition to our number in the shape of an Aku lady from Sierra Leone, who appeared to regard us with sovereign contempt.Poor thing!she soon became very sea-sick, and did not again turn up until we anchored off her des- tination, the capital of the West African settlements.Not a breeze ruffled the still, calm, glassy river; a few cirri-cumuli dotted the other- wise bright sky, the hygrometer running up to 83 and 87 in the shade at 9 A.M.; shortly after which we began to move slowly past the church, barracks, Government House, military and colonial hospitals, and the dismal-looking cemetery crowded with graves.As we swept round to the westward, the sea-breeze was gently stealing up towards uIS, a few cat's paws indicating its presence in the distance.The sense of relief when it did arrive catn scarcely be imagined by those who have not felt the oppressive damp heat of some of those tropical days, and the sense of exhaustion which accompanies it.The effect of the sea- breeze on this particular morining was the lowering of the mercury in the thermometer from 89 to 85-four degrees-and a perceptible feeling of already being in a cooler atmosphere.The suni set this evening at a quarter past 6 I).m.
Football.
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cerebellar toxicity with medium‐dose cytarabine in a young patient with renal insufficiency
Authors: C.S. Chim, Y.L. Kwong
Journal: American Journal of Hematology (1996)

a patient with myelodysplastic syndrome and acute myeloid leukemia evolving from polycythemia Vera (PV) treated with hydroxyurea for 4 years.A 43-year-old man presented with facial erythrosis and intense itching in June 1991.Physical examination revealed splenomegaly.Complete blood count revealed a red blood count of 8.4 X 10'2/1, hemoglobin of 24 gldl, hematocrit of 72.1%, white blood count (WBC) of 18 X 109/1, and a platelet count of 218 X 109/l.According to standard criteria the diagnosis of PV was made.In an attempt to promptly restore a normal red-cell mass, phlebotomy was performed.Four months later, the platelet count rose above 600 X 109/1, and the patient was then treated with hydroxyurea.The patient received between 1,000-2,000 mg/day with excellent control of blood counts.After 4 years of therapy with hydroxyurea he developed pancytopenia.The dose of hydroxyurea was decreased but the cell counts worsened and he developed bone pain, asthenia, and splenomegaly.The hydroxyurea was stopped, and a bone-marrow examination was performed, revealing massive trilineage hyperplasia with marked cytologic abnormalities, 27% of ringed sideroblasts, and a 20% increase of immature myeloid forms.Cytogenetic analysis revealed -1, -5, -9, -17,7p+, 12p+, de1(17)(q23).Ten days later the WBC rose to 81 X 109/l.Bone-marrow examination was repeated and revealed acute myeloid leukemia, FAB type M5.He was induced with doxorubicin and cytosine arabinoside (3 + 7 regimen), but
Miscellany.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE TREATMENT OF NASAL CATARRH IN THE LONDON CENTRAL THROAT, NOSE AND EAR HOSPITAL.
Authors: FAYETTE CLAY EWING
Journal: JAMA (1896)

It occurred to the writer that the treatment of the several forms of nasal catarrh pursued in the Central Hospital would prove interesting to many of the readers of theJournal.<sup>1</sup>Five varieties are recognized, viz: Acute, chronic, hypertrophic, chronic atrophic, croupous and caseous. The first of these presents few cases in hospital practice, and the last two are so rare as to be regarded as clinical curiosities. <h3>Acute.</h3> —Since patients with this form of rhinitis rarely consult a physician until the acute stage has passed, little is attempted except prophylaxis. This includes abundant open air, exercise under restrictions, and hygienic dress. Light wool next the skin and variable weights of over-garments. Heavy garments indoors are specially cautioned against. No agent is more relied upon for its hardening effect than the morning sponge bath with cold water. This should be taken in a warm room, and supplemented by vigorous
Genetics and Brain Transcriptomics of Completed Suicide
Authors: Giovanna Punzi, Gianluca Ursini, Qiang Chen, Eugenia Radulescu, Ran Tao, Louise A. Huuki, Pasquale Di Carlo, Leonardo Collado-Torres, Joo Heon Shin, Roberto Catanesi, Andrew E. Jaffe, Thomas M. Hyde, Joel E. Kleinman, Trudy F.C. Mackay, Daniel R. Weinberger
Journal: American Journal of Psychiatry (2022)

Objective: The authors sought to study the transcriptomic and genomic features of completed suicide by parsing the method chosen, to capture molecular correlates of the distinctive frame of mind of individuals who die by suicide, while reducing heterogeneity. Methods: The authors analyzed gene expression (RNA sequencing) from postmortem dorsolateral prefrontal cortex of patients who died by suicide with violent compared with nonviolent means, nonsuicide patients with the same psychiatric disorders, and a neurotypical group (total N=329). They then examined genomic risk scores (GRSs) for each psychiatric disorder included, and GRSs for cognition (IQ) and for suicide attempt, testing how they predict diagnosis or traits (total N=888). Results: Patients who died by suicide by violent means showed a transcriptomic pattern remarkably divergent from each of the other patient groups but less from the neurotypical group; consistently, their genomic profile of risk was relatively low for their diagnosed illness as well as for suicide attempt, and relatively high for IQ: they were more similar to the neurotypical group than to other patients. Differentially expressed genes (DEGs) associated with patients who died by suicide by violent means pointed to purinergic signaling in microglia, showing similarities to a genome-wide association study of Drosophila aggression. Weighted gene coexpression network analysis revealed that these DEGs were coexpressed in a context of mitochondrial metabolic activation unique to suicide by violent means. Conclusions: These findings suggest that patients who die by suicide by violent means are in part biologically separable from other patients with the same diagnoses, and their behavioral outcome may be less dependent on genetic risk for conventional psychiatric disorders and be associated with an alteration of purinergic signaling and mitochondrial metabolism.
Who shall inherit the earth?
Authors: J. S. Chapman
Journal: JAMA (1971)

A newly published book<sup>1</sup>will stimulate all thoughtful physicians. The authors, Paul and Anne Ehrlich, are biologists, and their concern stems from the "population explosion." Basically, their thesis is neo-Malthusian: population can increase logarithmically while resources can increase only arithmetically. "Resources" applies not only to sources of nutrition, but to soil, water, air, and all "lifesupport" systems on this planet. In the long view, there can be no dispute that humans can reproduce to some infinite point, and equally none that all resources are finite. In a natural, nontechnological system the results of disparity between medium and population areentirely predictable. But some biologists suspect there may be other factors than predation, disease, and limitation of sustenance that control population levels. (Robert Ardrey is a most vocal popularizer of these other possibilities, especially in The Territorial Imperative [1966] and in his current book, The Social Contract [1970].) If these other
SARS-CoV-2 Laboratory-Developed Tests
Authors: Eli Y. Adashi, I. Glenn Cohen
Journal: JAMA (2022)

Guillaume Butler-Laporte, MD; Alexander Lawandi, MD, MSc; Ian Schiller, MSc; Mandy Yao, BSc; Nandini Dendukuri, PhD; Emily G. McDonald, MD, MSc; Todd C. Lee, MD, MPH
Age-Adjusted Survival Extrapolations—Results May Differ From Those Generated by the Weibull Model—Reply
Authors: Pardeep S. Jhund, Kieran F. Docherty, John J. V. McMurray
Journal: JAMA Cardiology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Renal transplantation from cadavers.
Journal: BMJ (1972)

Renal Transplantation from CadaversA long and enjoyable reprieve for a patient in chronic renal failure is best ensured by a well-matched graft from a sib- ling or parent.Graft survival now averages over 70% and patient survival about 80% at two years.1 2 If the graft is from an HL-A identical sib, prolonged survival and freedom from excessive immunosuppression are virtually assured.3 4 But only a few patients have a suitable, healthy, and willing donor, and only 107 live donor operations were reported to the European registry in a year when more than 3,000 new patients were accepted for treatment.2The remainder must choose between permanent haemodialysis and cadaver grafting.Nationally we are now committed to offering cadaver grafts to most of our patients.The decision is easy to defend in the round.After five years of strenuous effort the dialysis service was accepting only about 500 patients a year5 out of an estimated potential of about 2,500,6 7 and expansion of facilities for offering a cadaver transplant seemed the only chance of meeting the whole need in the foreseeable future.This expansion is now under way.The National Kidney Exchange Service at Bristol serves about 650 patients, and in the 3' months from its inauguration in February 1972 it has handled 130 transplants.8But the decision to back cadaver grafting was based on hope rather than ex- perience.The initial results reviewed in these columns in 19639 10 made dismal reading.Of -the first 24 British cases only one patient was alive after more than three months."1-'3Though there has been a steady improvement since, the latest reported series are still far from encouraging.The International Transplant Registry recorded a two-year graft survival of 41%, no better than the previous year.'In Europe the two-year graft survival was 50%, but patient survival at 63% was poorer than that of hospital dialysis (70%) and much poorer than that of home dialysis (84%).2These figures must be interpreted cautiously as the groups were not selected randomly, but if anything they are prob- ably unfair to hospital dialysis.2Certainly they must give pause to the clinician advising his dialysis patient whether to accept a cadaver graft.In addition to the increased mor- tality the patient faces a 10-20% chance of developing a urinary leak or other urological complication,14 15 and an appreciable risk of gastrointestinal haemorrhage, perfora- tion, or bowel ischaemia1l61 or a debilitating infection with opportunist bacteria, fungi, protozoa, or viruses.19-21He may suffer a recurrence of hypertension from renal artery
Positive Smear in Pregnancy
Authors: H. C. McLaren
Journal: BMJ (1969)

Of 8,500 consecutive cervical cytology tests in the antenatal period a positive or suspect result was found in about 1%. For the patients with a positive smear, examination under anaesthesia and small four-quadrant cervical biopsies are proposed as an alternative to antenatal conization, with its risk of subsequent haemorrhage or abortion. A waiting policy is safe and permits normal delivery in hospital. Clinical and cytological follow-up is a vital part of conization-excision therapy. For the suspect smear (dyskaryosis) follow-up tests may revert to normal, but others may become positive and demand biopsy.
Comment on Fahrmann et al. Modification of the Association Between Severe Hypoglycemia and Ischemic Heart Disease by Surrogates of Vascular Damage Severity in Type 1 Diabetes During ∼30 Years of Follow-up in the DCCT/EDIC Study. Diabetes Care 2021;44;2132–2139
Authors: José-Miguel González-Clemente, Gemma Llauradó, Ana Romero, Olga Giménez-Palop, Eugenio Berlanga, Joan Vendrell
Journal: Diabetes Care (2022)