tbuckley/cabot-search huggingface dataset:
Variations in 35SO4 incorporation into glycosaminoglycans along canine coronary arteries. A possible index of artery wall stress.
Authors: R JBoucek, N LNoble, D EWells
Journal: Circulation Research (1976)

Focal areas of accentuated wall stress along the course of canine coronary arteries may be revealed by the level of 35SO4 incorporation into glycosaminoglycans (GAG). In the anterior descending artery, 35SO4 incorporation in higher in the proximal than in the distal region and may be extraordinarily high as the vessel enters a proximally located muscle bridge and at the takeoff region of multidirectional branches. In the circumflex artery, the incorporation also is higher in the proximal than in the distal region and is high at the genu where the posterior descending artery forms. There are differences in uptake of 35SO4 in vessels even when the arteries arise from the same vascular bed.this was shown by the higher incorporation in the left coronary artery than in the right coronary artery. A general anatomical agreement exists between these sites of high 35SO4 incorporation and previously described locations of interval elastic disruption ans proliferation of intimal connective tissue in the dog.
Resting electrocardiographic abnormalities suggestive of asymptomatic ischemic heart disease associated with non-insulin-dependent diabetes mellitus in a defined population.
Authors: CScheidt-Nave, EBarrett-Connor, D LWingard
Journal: Circulation (1990)

The prevalence of ischemic heart disease (IHD) in older adults by glucose tolerance status was evaluated in 2,223 white men and women, aged 50-89 years, in the Rancho Bernardo cohort who were studied between 1984 and 1987. Impaired glucose tolerance (IGT) and non-insulin-dependent diabetes mellitus (NIDDM) were classified according to World Health Organization criteria. End points of ischemic heart disease were defined by Rose Questionnaire and resting electrocardiogram (ECG) according to the Minnesota Code. IHD by electrocardiographic changes was classified as asymptomatic (without history of chest pain or overt IHD) or symptomatic (with history). IHD by all criteria combined was significantly more common in men and women with NIDDM, and in women with IGT, than in those with normal glucose tolerance. The prevalence of myocardial infarction, defined by major Q wave, Rose Questionnaire chest pain criteria, or personal history, was higher in persons with NIDDM than in persons without; the difference was hig...
Interobserver variability in the pathologic interpretation of endomyocardial biopsy results.
Authors: J GShanes, JGhali, M EBillingham, V JFerrans, J JFenoglio, W DEdwards, C CTsai, J ESaffitz, JIsner, SFurner
Journal: Circulation (1987)

Controversy exists over the role of endomyocardial biopsy in evaluating patients with dilated cardiomyopathy, particularly in detecting myocarditis and in assessing prognosis. Interobserver variability, if high, could explain conflicting reports. To assess this possibility, we submitted biopsy specimens from 16 patients with dilated cardiomyopathy to seven cardiac pathologists. The same slides were independently reviewed by each and assessed for fibrosis, hypertrophy, nuclear changes on a 0 to 3+ scale, mean lymphocyte count per high-power field, and myocarditis. The prevalance of significant fibrosis ranged from 25% to 69%, hypertrophy from 19% to 88%, nuclear changes from 31% to 94%, and abnormal lymphocyte count from 0 to 38%. One or more pathologists diagnosed definite or possible myocarditis in 11 of the 16 patients. Of these 11 patients, three pathologists agreed about three and two pathologists agreed about five. Myocarditis was diagnosed by a single pathologist in three cases. We conclude that int...
From the authors:
Authors: Y. Song, X. Li, X. Du
Journal: European Respiratory Journal (2009)

from the study in humans by SONG et al. [1] and our in vivo studies may provide an important finding regarding difference in susceptibility to nanoparticles between humans and rodents.The second point to be addressed is the possibility of endotoxin attaching to (around) the nanoparticles.Do the authors have any information about endotoxin level in the lung samples or endotoxin concentration in the workplace?We have previously demonstrated that combined exposure to nanoparticles and endotoxin elicited devastating lung injury compared to nanoparticles or endotoxin alone [4].The lethal events occurring in the patients may have resulted from synergistic effects of nanoparticles with other toxic substances, rather than effects of the nanoparticles alone.Finally, we would like to know if these seven patients had pre-existing atopy.In particular, we are interested in the physical condition of the patients described in ''The general characteristics of the patients'' section in which ''all patients suffered from rash with intense itching on their faces'' [1], implicating an association with some immunological impairment.Allergen-specific immunoglobulin (Ig)E titres examined by radioallergosorbent test could provide hints for detection, as total IgE (measured by radioimmunosorbent test) does not always cover allergic conditions.Furthermore, atopic subjects are prone to particulate matter (PM), i.e.PM exposure significantly exacerbates the pathophysiology in the subjects [2, 5], sometimes leading to a fatal outcome.A careful search for pre-existing illness (in particular, atopy) may have helped in resolving the pathogenesis of the lung damage seen in the patients.In any case, the study by SONG et al. [1] is valuable for future inhalation toxicology, and environmental and preventive medicine, if correlated to previous in vivo findings.
Digitalis and myocardial infarction in man.
Authors: JMorrison, JCoromilas, MRobbins, LOng, SEisenberg, RStechel, MZema, PReiser, LScherr
Journal: Circulation (1980)

The use of digitalis after acute myocardial infarction is controversial. The effect of digoxin on computer-quantitated thallium-201 perfusion scintigrams (Tl-201), left ventricular (LV) ejection fraction (EF), and percentage of abnormally contracting LV regions (% ACR) was determined in 23 patients. A correlation was established between creatine kinase MB isoenzyme release and initial radionuclide-gated blood pool wall motion estimates of EF (r = -0.73) and % ACR (r = 0.71). After radionuclide assessments, 14 patients received digoxin 18 +/- 23 hours (mean +/- SD) after the rise in CK-MB from baseline, while the remaining nine patients served as controls. In the control group, the mean EF was 0.33 +/- 0.12 on the first study and 0.30 +/- 0.08 on the second study (p = NS). In the digoxin group, the EF after digoxin administration (mean 0.33 +/- 0.11) was significantly different from the initial EF (mean 0.29 +/- 0.09, p less than 0.03); however, digoxin had no apparent effect on infarct size as assessed by...
Clostridium difficile in toxic megacolon.
Journal: BMJ (1982)

showed, in addition, early caecal perforation in the area of maximum dilatation.Histologically, although the bowel wall was thinned, the reason for the dilatation was not apparent.In all cases the ulceration remained super- ficial, ganglion cells appeared normal, and there was only a mild inflammatory cell infiltrate.Even if future studies confirm the association between Cl difficile and toxic megacolon of inflammatory bowel disease, the vital clinical message is that careful patient monitoring will still be mandatory.Despite the availability of antibiotics to treat Cl difficile, its associated toxic dilatation can still be fatal, the bowel can perforate, and surgical resection may be necessary.
4-g Monofilament Is Clinically Useful for the Detection of Diabetic Peripheral Neuropathy
Authors: Marg McGill, Linda Molyneaux, Rosemary Spencer, Lee Fan Heng, Dennis K. Yue
Journal: Diabetes Care (2001)

We agree with Nagai et al. (1) that the Semmes-Weinstein 10-g monofilament detects severe rather than mild diabetic peripheral neuropathy. However, the choice of monofilament to be used in clinical practice is based on its intended purpose. In our work, we …
Mitral valve replacement combined with myocardial revascularization: early and late results for 300 patients, 1970 to 1983.
Authors: B WLytle, D MCosgrove, C CGill, R WStewart, L AGolding, MGoormastic, P CTaylor, F DLoop
Journal: Circulation (1985)

Of 300 consecutive patients undergoing primary operation for mitral valve replacement combined with coronary bypass grafting, 22 (7.3%) died in-hospital. Multivariate testing of preoperative and operative descriptors identified radiographic cardiac enlargement, preoperative paced rhythm or atrial fibrillation, 70% or more left main coronary obstruction, and serum bilirubin of more than 2 mg% as factors associated with an increase in in-hospital mortality. Follow-up of the 278 hospital survivors (mean interval 48 months, range 2 to 165 months) documented survival of 85%, 66%, and 31% and an event-free survival of 65%, 46%, and 21% at 2, 5, and 10 postoperative years, respectively. Cox proportional-hazard regression models of late risk implicated in-hospital ventricular arrhythmias, left ventricular dysfunction, and rheumatic or ischemic causes of mitral valve disease in decreasing long-term survival. In addition, patients with bioprostheses without warfarin anticoagulation had better survival and event-fre...
Factors that modify the flow response to intracoronary injections.
Authors: HEmanuelsson, SHolmberg, KSelin, JWallin
Journal: Circulation (1985)

Coronary sinus flow (CSF) was measured in seven patients with normal coronary arteries (group A) during intracoronary injections of 6 ml arterial blood, 6 ml blood from the coronary sinus, 3 and 6 ml isotonic saline, 3 and 6 ml hypertonic glucose, and 6 ml of a contrast agent (sodium metrizoate). In 10 patients with coronary artery disease (group B), CSF was measured after administration of 6 ml isotonic saline, 6 ml sodium metrizoate, and 6 ml of another contrast medium (iohexol). In group A, arterial blood did not affect CSF, while coronary sinus blood induced a 33% increase. After 6 ml isotonic saline, there was a 35% increase in flow and after hypertonic glucose an increase of 70%. Metrizoate induced a rise in flow of 109%. In group B, the increase in CSF after intracoronary injection of saline, metrizoate, and iohexol was 30%, 83%, and 67%, respectively. Blood from the coronary sinus, in contrast to arterial blood, induced a marked rise in peak flow, suggesting a role for reactive hyperemia secondary...
Epidemiology and risk factors for the development of cutaneous toxicities in patients treated with immune-checkpoint inhibitors: A United States population-level analysis
Authors: Shannon Wongvibulsin, Vartan Pahalyants, Mark Kalinich, William Murphy, Kun-Hsing Yu, Feicheng Wang, Steven T. Chen, Kerry Reynolds, Shawn G. Kwatra, Yevgeniy R. Semenov
Journal: Journal of the American Academy of Dermatology (2021)
The course of acute myocardial infarction. Feasibility of early discharge of the uncomplicated patient.
Authors: J FMcNeer, A GWallace, G SWagner, C FStarmer, R ARosati
Journal: Circulation (1975)

This report represents our experience with 522 consecutive patients with acute myocardial infarction admitted directly to the Duke Coronary Care Unit. Fifty items of information were used to characterize the patients, their hospital course and follow-up. Serious complications included death, ventricular tachycardia or fibrillation, second- or third-degree heart block, pulmonary edema, cardiogenic shock, persistent sinus tachycardia or hypotension, atrial flutter or fibrillation, and extension of infarction. Forty-nine percent of the patients (252 of 522) experienced a serious complication. All patients who experienced any serious complications had at least one of the above during the first four days of hospitalization. Patients who survived through day 4 were subgrouped on the basis of the occurrence (complicated) or lack of occurrence (uncomplicated) of the above on day 5. Complicated patients had a subsequent hospital mortality of 14% and an incidence of late serious complications of 51%. Patients who w...
Real-time NMR beam-directed velocity mapping. V-mode NMR.
Authors: J DPearlman, J RMoore, M JLizak
Journal: Circulation (1992)

BACKGROUNDCurrently available noninvasive techniques for measuring blood flow velocities are constrained by limited view orientations (Doppler ultrasound) or limited time resolution (magnetic resonance imaging, MRI). We describe an MRI technique for measuring flow velocities in real time at arbitrary orientations within a cylindrical volume or beam: V-mode nuclear magnetic resonance (NMR).METHODS AND RESULTSThe technique was implemented on a standard 1.5-T clinical NMR imager with no special hardware and was tested on phantoms and human volunteers. The beam can be fired at rates up to 60 times per second, allowing measurements on a time scale that is appropriate for ungated cardiac studies. In phantoms, steady flow velocities were measured with the beam aligned along the direction of flow, and the measured velocities correlated well with the actual velocities (r > 0.99). The radial distribution of velocities in phantoms under constant flow conditions was also determined. In humans, flow of blood in the ...
A critical review of the systolic time intervals.
Authors: R PLewis, S ERittogers, W FFroester, HBoudoulas
Journal: Circulation (1977)

The theoretical basis for the use of the systolic time intervals has been largely established. The method has been validated by direct measures from within the circulatory system. Standards for equipment and technique have been defined. Numerous clinical studies have demonstrated the value of this quantitative noninvasive technique for assessing left ventricular performance. At present there is need for further studies of the clinical usefulness of the systolic time intervals to improve both diagnosis and therapy of various cardiovascular disorders.
Time course of changes in porcine myocardial phospholipid levels during ischemia. A reassessment of the lysolipid hypothesis.
Authors: N AShaikh, EDownar
Journal: Circulation Research (1981)

This study was performed to determine the early and delayed metabolic effects of myocardial ischemia on the major membrane phospholipids and to reassess the potential role of lysophospholipids in the genesis of malignant dysrhythmias induced by ischemia. Samples taken from in situ hearts before ant at various intervals up to 40 minutes after abrupt ligation of LAD were extracted by the classical Folch technique with modifications to avoid artifactual lysophospholipid production and losses. Following thin layer chromatography of lipid extracts, phospholipid fractions were quantified by phosphorus estimation and lysophospholipids by a more sensitive method employing gas liquid chromatography. The total phospholipid content with the exception of lysophospholipids remained essentially constant throughout the early phases of acute ischemia, but fell by 6 and 14% after 8 and 24 ours, respectively. At 8 minutes, lysophospholipid levels n ischemic myocardium were significantly increased by 60% compared to pre-occ...
Arterial baroreflex control of sympathetic nerve activity during elevation of blood pressure in normal man: dominance of aortic baroreflexes.
Authors: J SSanders, D WFerguson, A LMark
Journal: Circulation (1988)

Arterial baroreceptors in the carotid sinus (CBR) and aortic arch (ABR) regions exert important control over heart rate and peripheral vascular responses to changes in arterial pressure. The relative roles of these two baroreflex pathways on control of sympathetic nerve activity during sustained elevation of arterial pressure in man is unknown. We therefore studied the relative contributions of the carotid versus the aortic baroreflexes on the control of muscle sympathetic nerve activity (MSNA) during elevation of arterial pressure in normal human subjects. In eight normal men (group I), we measured MSNA (microneurography) during sustained elevation of arterial pressure produced by intravenous infusion of phenylephrine (PE) alone (combined ABR and CBR activation) versus during PE infusion with superimposed application of sustained external neck pressure (NP). NP was applied during sustained PE infusion to eliminate the increase in transmural carotid sinus pressure and thus remove CBR activation, thereby c...
Intimal injury and regrowth in the rabbit aorta; medial smooth muscle cells as a source of neointima.
Authors: T HSpaet, M BStemerman, F JVeith, ILejnieks
Journal: Circulation Research (1975)

The present study was undertaken to determine the mechanism of neointima formation in rabbit arteries subjected to extensive endothelial desquamation. Endothelial cells were selectively removed from the abdominal aorta by passing an inflated balloon catheter through the vessel. The healing response was then studied serially for up to a week, when neointima formation had provided a virtually complete cover. In en face preparations, the early neointimal cells appeared in random locations; they did not develop in apposition to residual, healthy endothelium. The possibility of blood cell colonization was explored by inserting killed aortic homografts. Since these homografts showed neointima formation only close to the site of junction with the normal aorta and as a direct extension of healthy endothelium, the likelihood of significant blood cell colonization was deemed small. Histologic and electron microscopic sections provided evidence that the early neointimal cells in the healing aorta were derived from m...
HIJC-HF登録でうっ血性心不全結果を示す入院患者の臨床的性質と結果 | 文献情報 | J-GLOBAL 科学技術総合リンクセンター
Authors: Kawashiro Naomi, Kasanuki Hiroshi, Ogawa Hiroshi, Matsuda Naoki, Hagiwara Nobuhisa
Journal: Circulation (2008)
Effects of ouabain and isoproterenol on left ventricular diastolic function during low-flow ischemia in isolated, blood-perfused rabbit hearts.
Authors: B HLorell, SIsoyama, W NGrice, E OWeinberg, C SApstein
Journal: Circulation Research (1988)

Myocardial ischemia causes both systolic and diastolic dysfunction. A variety of positive inotropic agents with different subcellular mechanisms may be used clinically in an attempt to reverse ischemic contractile failure. We tested the hypothesis that two inotropic agents, isoproterenol (a beta-adrenergic agonist) and ouabain (a sodium pump inhibitor), might have different effects on left ventricular (LV) diastolic function during ischemic failure despite an equivalent inotropic effect. Isolated isovolumic (balloon-in-LV) blood perfused rabbit hearts were paced at constant physiological heart rate (4 Hz), given either no drug (controls, n = 7), isoproterenol (n = 7), or ouabain (n = 7), and then subjected to 6 minutes of low flow ischemia (75% reduction of baseline coronary flow). The doses of isoproterenol and ouabain were selected to produce equivalent modest inotropic effects (15% increase in LV + dP/dt) in each heart during baseline perfusion conditions. During the ischemic period, there was a marked...
Metabolism and excretion of nitric oxide in humans. An experimental and clinical study.
Authors: AWennmalm, GBenthin, AEdlund, LJungersten, NKieler-Jensen, SLundin, U NWestfelt, A SPetersson, FWaagstein
Journal: Circulation Research (1993)

Despite the increasing insight in the clinical importance of nitric oxide (NO), formerly known as endothelium-derived relaxing factor (EDRF), there is limited information about the metabolism and elimination of this mediator in humans. We studied the degradation of NO in healthy subjects inhaling 25 ppm for 60 minutes and in patients with severe heart failure inhaling 20, 40, and 80 ppm in consecutive 10-minute periods. In other healthy subjects, the renal clearance of NO metabolite was measured. The metabolism ex vivo was evaluated by direct incubation of nitrite, the NO oxidation product, in blood from healthy humans. During inhalation of NO, the plasma levels of nitrate increased progressively, both in the healthy subjects (from 26 to 38 mumol/L, P < .001) and in the patients (from 72 to 90 mumol/L, P < .001). Methemoglobin (MetHb) also increased in the healthy subjects (from 7 to 13 mumol/L, P < .001) as well as in the patients (from 19 to 42 mumol/L, P < .01). No change in nitrosohemoglobin (HbNO) wa...
Captopril restores hemodynamic responsiveness to atrial natriuretic peptide in rats with heart failure.
Authors: T ERaya, R WLee, TWesthoff, SGoldman
Journal: Circulation (1989)

Atrial natriuretic peptide levels are elevated in heart failure. However, the hemodynamic responses to exogenous atrial natriuretic peptide infusion in heart failure are blunted. To determine if captopril can restore hemodynamic responsiveness to atrial natriuretic peptide infusion in rats with heart failure, studies were performed in a rat model of heart failure after coronary artery ligation. Rats with heart failure received either captopril (2 g/l drinking water) or placebo for 4 weeks and then were treated with an infusion of atrial natriuretic peptide (0.3 microgram/kg/min). Captopril treatment alone improved hemodynamics. Left ventricular end-diastolic pressure, mean aortic pressure, and mean circulatory filling pressure decreased from 22 +/- 2 to 14 +/- 1, from 106 +/- 4 to 76 +/- 3, and from 10.5 +/- 0.6 to 8.8 +/- 0.4 mm Hg, respectively. Heart rate, right atrial pressure, and hematocrit were unchanged. Total blood volume decreased from 66.0 +/- 1.0 to 60.0 +/- 1.0 ml/kg; venous compliance increa...