tbuckley/cabot-search huggingface dataset:
Post-polypectomy surveillance interval and advanced neoplasia detection rates: a multicenter, retrospective cohort study
Authors: Amanda J. Cross, Emma C. Robbins, Kevin Pack, Iain Stenson, Matthew D. Rutter, Andrew M. Veitch, Brian P. Saunders, Stephen W. Duffy, Kate Wooldrage
Journal: Endoscopy (2022)

Abstract Background Longer post-polypectomy surveillance intervals are associated with increased colorectal neoplasia detection at surveillance in some studies. We investigated this association to inform optimal surveillance intervals. Methods Patients who underwent colonoscopy and post-polypectomy surveillance at 17 UK hospitals were classified as low/high risk by baseline findings. We compared detection rates of advanced adenomas (≥ 10 mm, tubulovillous/villous, high grade dysplasia), high risk findings (HRFs: ≥ 2 serrated polyps/[adenomas] of which ≥ 1 is ≥ 10 mm or has [high grade] dysplasia; ≥ 5 serrated polyps/adenomas; or ≥ 1 nonpedunculated polyp ≥ 20 mm), or colorectal cancer (CRC) at surveillance colonoscopy by surveillance interval (&lt; 18 months, 2, 3, 4, 5, 6 years). Risk ratios (RRs) were estimated using multivariable regression. Results Of 11 214 patients, 7216 (64 %) were low risk and 3998 (36 %) were high risk. Among low risk patients, advanced adenoma, HRF, and CRC detection rates at first surveillance were 7.8 %, 3.7 %, and 1.1 %, respectively. Advanced adenoma detection increased with increasing surveillance interval, reaching 9.8 % with a 6-year interval (P trend &lt; 0.001). Among high risk patients, advanced adenoma, HRF, and CRC detection rates at first surveillance were 15.3 %, 10.0 %, and 1.5 %, respectively. Advanced adenoma and CRC detection rates (P trends &lt; 0.001) increased with increasing surveillance interval; RRs (95 % confidence intervals) for CRC were 1.54 (0.68–3.48), 4.44 (1.95–10.08), and 5.80 (2.51–13.40) with 3-, 4-, and 5-year intervals, respectively, versus an interval of &lt; 18 months. Conclusions Metachronous neoplasia was uncommon among low risk patients, even with long surveillance intervals, supporting recommendations for no surveillance in these patients. For high risk patients, a 3-year surveillance interval would ensure timely CRC detection.
TCTAP A-011 The Burden of Short-Term Major Adverse Cardiac Events and Its Determinants After Emergency Percutaneous Coronary Revascularization: A Prospective Follow-up Study
Authors: Rajesh Kumar, Nadeem Qamar, Tahir Saghir, Jawaid Akbar Sial, Naveedullah Khan, Musa Karim
Journal: Journal of the American College of Cardiology (2022)
The Global Burden of Polyneuropathy—In Need of an Accurate Assessment
Authors: Melissa A. Elafros, Michelle P. Kvalsund, Brian C. Callaghan
Journal: JAMA Neurology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
TCTAP A-040 Big Endothelin-1 and Five-Year Long-term All-cause Death in Patients With Coronary Artery Disease and Prediabetes or Diabetes after Percutaneous Coronary Intervention
Authors: Na Xu, Sida Jia, Deshan Yuan, Jingjing Xu, Huanhuan Wang, Ying Song, Lijian Gao, Zhan Gao, Runlin Gao, Bo Xu, Jinqing Yuan
Journal: Journal of the American College of Cardiology (2022)
Pangenome-based genome inference allows efficient and accurate genotyping across a wide spectrum of variant classes
Authors: Jana Ebler, Peter Ebert, Wayne E. Clarke, Tobias Rausch, Peter A. Audano, Torsten Houwaart, Yafei Mao, Jan O. Korbel, Evan E. Eichler, Michael C. Zody, Alexander T. Dilthey, Tobias Marschall
Journal: Nature Genetics (2022)

Abstract Typical genotyping workflows map reads to a reference genome before identifying genetic variants. Generating such alignments introduces reference biases and comes with substantial computational burden. Furthermore, short-read lengths limit the ability to characterize repetitive genomic regions, which are particularly challenging for fast k -mer-based genotypers. In the present study, we propose a new algorithm, PanGenie, that leverages a haplotype-resolved pangenome reference together with k -mer counts from short-read sequencing data to genotype a wide spectrum of genetic variation—a process we refer to as genome inference. Compared with mapping-based approaches, PanGenie is more than 4 times faster at 30-fold coverage and achieves better genotype concordances for almost all variant types and coverages tested. Improvements are especially pronounced for large insertions (≥50 bp) and variants in repetitive regions, enabling the inclusion of these classes of variants in genome-wide association studies. PanGenie efficiently leverages the increasing amount of haplotype-resolved assemblies to unravel the functional impact of previously inaccessible variants while being faster compared with alignment-based workflows.
Humoral response after a fourth “booster” dose of a Coronavirus disease 2019 vaccine following a 3-dose regimen of mRNA-based vaccination in dialysis patients
Authors: Pierre Housset, Sabah Kubab, Latifa Hanafi, Agathe Pardon, Nathalie Vittoz, Dogan-Firat Bozman, Valérie Caudwell, Anne-Laure Faucon
Journal: Kidney International (2022)
Trends in Drug Overdose Deaths Among US Adolescents, January 2010 to June 2021
Authors: Joseph Friedman, Morgan Godvin, Chelsea L. Shover, Joseph P. Gone, Helena Hansen, David L. Schriger
Journal: JAMA (2022)

This study assesses trends in drug overdose deaths among US adolescents aged 14 to 18 years from January 2010 to June 2021, by substance type and race and ethnicity, using data from the Centers for Disease Control and Prevention WONDER database.
Diarrhea during critical illness: a multicenter cohort study
Authors: Joanna C. Dionne, Lawrence Mbuagbaw, John W. Devlin, Matthew S. Duprey, Rodrigo Cartin-Ceba, Jennifer Tsang, Kristen Sullivan, John Muscedere, Mohammed Alshahrani, Wojciech Szczeklik, Paul Lysecki, Alyson Takaoka, Brenda Reeve, Tracy Campbell, Karolina Borowska, Wojciech Serednicki, Robert Cirone, Waleed Alhazzani, Paul Moayyedi, David Armstrong, Lehana Thabane, Roman Jaeschke, Cindy Hamielec, Tim Karachi, Deborah J. Cook, J. Tsang, Dimitra Fleming, Susan O’Farrell, Brittany Young, Allison Brown, Helen Su, Robin Owen, Kathryn Lalonde, Kathleen Willis, P. Lysecki, T. Campbell, D. Cook, K. Sullivan, A. Takaoka, R. Cirone, K. Kavikondala, C. Hamielec, K. Sullivan, T. Karachi, K. Sullivan, J. Devlin, M. Duprey, R. Cartin-Ceba, H. Raza, B. Nokes, J. Muscedere, M. Hunt, I. Georgescu, A. Alshahrani, L. P. Asonto, B. Reeve, W. Dechert, W. Szczeklik, K. Borowska
Journal: Intensive Care Medicine (2022)
Percutaneous Pulmonary Angioplasty for Patients With Takayasu Arteritis and Pulmonary Hypertension
Authors: Yu-Ping Zhou, Yun-Peng Wei, Yin-Jian Yang, Xi-Qi Xu, Tao Wu, Chao Liu, Ke-Yi Mei, Fu-Hua Peng, Hai-Ping Wang, Kai Sun, Jing-Yi Li, Hui-Fang Wang, Meng-Tao Li, Duo-Lao Wang, Qi Miao, Xin Jiang, Zhi-Cheng Jing
Journal: Journal of the American College of Cardiology (2022)
Reduction of dietary sodium to less than 100 mmol in heart failure (SODIUM-HF): an international, open-label, randomised, controlled trial
Authors: Justin A Ezekowitz, Eloisa Colin-Ramirez, Heather Ross, Jorge Escobedo, Peter Macdonald, Richard Troughton, Clara Saldarriaga, Wendimagegn Alemayehu, Finlay A McAlister, JoAnne Arcand, John Atherton, Robert Doughty, Milan Gupta, Jonathan Howlett, Shahin Jaffer, Andrea Lavoie, Mayanna Lund, Thomas Marwick, Robert McKelvie, Gordon Moe, A Shekhar Pandey, Liane Porepa, Miroslaw Rajda, Haunnah Rheault, Jitendra Singh, Mustafa Toma, Sean Virani, Shelley Zieroth, Justin Ezekowitz, Eloisa Colin-Ramirez, Heather Ross, Jorge Escobedo, Peter Macdonald, Richard Troughton, Clara Saldarriaga, Wendimagegn Alemayehu, Finlay McAlister, JoAnne Arcand, John Atherton, Robert Doughty, Milan Gupta, Jonathan Howlett, Shahin Jaffer, Andrea Lavoie, Mayanna Lund, Thomas Marwick, Robert McKelvie, Gordon Moe, A. Shekhar Pandey, Liane Porepa, Miroslaw Rajda, Haunnah Rheault, Jitendra Singh, Mustafa Toma, Sean Virani, Shelley Zieroth
Journal: The Lancet (2022)
TCTAP C-027 When Encountering Double Trouble, Primary Orbital Atherectomy Delivers a Niche Solution: Safe and Effective Use of Upfront Orbital Atherectomy in Heavily Calcified Chronic Total Occlusion
Authors: Zhong Shiun Lee, Adriyawan Widya Nugraha, Shahul Hamid Bin K A Ahmadsah, Muhamad Ali SK Abdul Kader
Journal: Journal of the American College of Cardiology (2022)
Centering Young People’s Perspectives, Needs, and Preferences in Research Regarding Barriers to Medications for Opioid Use Disorder—Reply
Authors: Andreas Pilarinos, Daniel J. Bromberg, Mohammad Karamouzian
Journal: JAMA Pediatrics (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Correction: Genetic correlates in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with Hyper-CVAD plus dasatinib or ponatinib
Authors: Yuya Sasaki, Hagop M. Kantarjian, Nicholas J. Short, Feng Wang, Ken Furudate, Hidetaka Uryu, Rebecca Garris, Nitin Jain, Koji Sasaki, Farhad Ravandi, Marina Konopleva, Guillermo Garcia-Manero, Latasha Little, Curtis Gumbs, Li Zhao, P. Andrew Futreal, Koichi Takahashi, Elias Jabbour
Journal: Leukemia (2022)
Sleep Recording for the Diagnosis and Treatment of Paraplegia
Authors: Raphaël Vollhardt, Isabelle Arnulf, Béatrice Garcin
Journal: JAMA Neurology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Treatment Effects in Analysis of Pooled Individual Patient Data From Randomized Trials of Device Closure of Patent Foramen Ovale—Reply
Authors: David M. Kent, Jeffrey L. Saver, David E. Thaler
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Association of Telehealth Reimbursement Parity With Contraceptive Visits During the COVID-19 Pandemic
Authors: Jacqueline Ellison, Megan B. Cole, Terri-Ann Thompson
Journal: JAMA Network Open (2022)

This cross-sectional study assesses the pattern of face-to-face and virtual contraceptive appointments in states in which insurers reimbursed both services equally vs states without a reimbursement parity policy.
Exome sequencing of individuals with Huntington’s disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset
Authors: Branduff McAllister, Jasmine Donaldson, Caroline S. Binda, Sophie Powell, Uroosa Chughtai, Gareth Edwards, Joseph Stone, Sergey Lobanov, Linda Elliston, Laura-Nadine Schuhmacher, Elliott Rees, Georgina Menzies, Marc Ciosi, Alastair Maxwell, Michael J. Chao, Eun Pyo Hong, Diane Lucente, Vanessa Wheeler, Jong-Min Lee, Marcy E. MacDonald, Jeffrey D. Long, Elizabeth H. Aylward, G. Bernhard Landwehrmeyer, Anne E. Rosser, Jane S. Paulsen, Nigel M. Williams, James F. Gusella, Darren G. Monckton, Nicholas D. Allen, Peter Holmans, Lesley Jones, Thomas H. Massey
Journal: Nature Neuroscience (2022)

Abstract The age at onset of motor symptoms in Huntington’s disease (HD) is driven by HTT CAG repeat length but modified by other genes. In this study, we used exome sequencing of 683 patients with HD with extremes of onset or phenotype relative to CAG length to identify rare variants associated with clinical effect. We discovered damaging coding variants in candidate modifier genes identified in previous genome-wide association studies associated with altered HD onset or severity. Variants in FAN1 clustered in its DNA-binding and nuclease domains and were associated predominantly with earlier-onset HD. Nuclease activities of purified variants in vitro correlated with residual age at motor onset of HD. Mutating endogenous FAN1 to a nuclease-inactive form in an induced pluripotent stem cell model of HD led to rates of CAG expansion similar to those observed with complete FAN1 knockout. Together, these data implicate FAN1 nuclease activity in slowing somatic repeat expansion and hence onset of HD.
Joint reply to 'Rewriting results in the language of compatibility' by V. Amrhein and S. Greenland, and to 'The evidence contained in the P-value is context dependent' by F. Hartig and F. Barraquand
Authors: Stefanie Muff, Erlend B. Nilsen, Chloé R. Nater, Robert B. O’Hara
Journal: Trends in Ecology & Evolution (2022)
Enhanced SARS-CoV-2 breakthrough infections in patients with hematologic and solid cancers due to Omicron
Authors: Maximilian J. Mair, Manfred Mitterer, Pia Gattinger, Julia M. Berger, Wolfgang Trutschnig, Arne C. Bathke, Margaretha Gansterer, Anna S. Berghoff, Severin Laengle, Lynn Gottmann, Thomas Buratti, Helmuth Haslacher, Wolfgang W. Lamm, Markus Raderer, Selma Tobudic, Thorsten Fuereder, Rudolf Valenta, Dominic Fong, Matthias Preusser
Journal: Cancer Cell (2022)
Interindividual variability in transgene mRNA and protein production following adeno-associated virus gene therapy for hemophilia A
Authors: Sylvia Fong, Bridget Yates, Choong-Ryoul Sihn, Aras N. Mattis, Nina Mitchell, Su Liu, Chris B. Russell, Benjamin Kim, Adebayo Lawal, Savita Rangarajan, Will Lester, Stuart Bunting, Glenn F. Pierce, K. John Pasi, Wing Yen Wong
Journal: Nature Medicine (2022)

Factor VIII gene transfer with a single intravenous infusion of valoctocogene roxaparvovec (AAV5-hFVIII-SQ) has demonstrated clinical benefits lasting 5 years to date in people with severe hemophilia A. Molecular mechanisms underlying sustained AAV5-hFVIII-SQ-derived FVIII expression have not been studied in humans. In a substudy of the phase 1/2 clinical trial ( NCT02576795 ), liver biopsy samples were collected 2.6-4.1 years after gene transfer from five participants. Primary objectives were to examine effects on liver histopathology, determine the transduction pattern and percentage of hepatocytes transduced with AAV5-hFVIII-SQ genomes, characterize and quantify episomal forms of vector DNA and quantify transgene expression (hFVIII-SQ RNA and hFVIII-SQ protein). Histopathology revealed no dysplasia, architectural distortion, fibrosis or chronic inflammation, and no endoplasmic reticulum stress was detected in hepatocytes expressing hFVIII-SQ protein. Hepatocytes stained positive for vector genomes, showing a trend for more cells transduced with higher doses. Molecular analysis demonstrated the presence of full-length, inverted terminal repeat-fused, circular episomal genomes, which are associated with long-term expression. Interindividual differences in transgene expression were noted despite similar successful transduction, possibly influenced by host-mediated post-transduction mechanisms of vector transcription, hFVIII-SQ protein translation and secretion. Overall, these results demonstrate persistent episomal vector structures following AAV5-hFVIII-SQ administration and begin to elucidate potential mechanisms mediating interindividual variability.
Transcriptomic profiles of neoantigen-reactive T cells in human gastrointestinal cancers
Authors: Chunhong Zheng, Joseph N Fass, Yi-Ping Shih, Andrew J Gunderson, Nelson Sanjuan Silva, Huayu Huang, Brady M Bernard, Venkatesh Rajamanickam, Joseph Slagel, Carlo B Bifulco, Brian Piening, Pippa H A Newell, Paul D Hansen, Eric Tran
Journal: Cancer Cell (2022)
Navigating Systemic Therapeutic Options for First-Line Metastatic Hormone Receptor–Positive,<i>ERBB2</i>-Negative Breast Cancer Treatment
Authors: Yehoda M. Martei, Amy S. Clark
Journal: JAMA Network Open (2022)

Ranking First-Line Anticancer Regimens for Hormone Receptor–Positive, ERBB2-Negative Metastatic Breast Cancer
Vaccine Uptake in the US After Full Food and Drug Administration Approval of the BNT162b2 mRNA COVID-19 Vaccine
Authors: Elise Vandersteen Bailey, Fernando A. Wilson
Journal: JAMA Network Open (2022)

This cross-sectional study examines the association of full approval of the BNT162b2 mRNA vaccine by the US Food and Drug Administration (FDA) with subsequent US uptake of COVID-19 vaccines of any kind.
Sociodemographic disparities in COVID-19 seroprevalence across England in the Oxford RCGP primary care sentinel network
Authors: Heather Whitaker, Ruby S.M. Tsang, Elizabeth Button, Nick Andrews, Rachel Byford, Ray Borrow, F.D. Richard Hobbs, Tim Brooks, Gary Howsam, Kevin Brown, Jack Macartney, Charlotte Gower, Cecilia Okusi, Jacqueline Hewson, Julian Sherlock, Ezra Linley, Manasa Tripathy, Ashley D. Otter, John Williams, Simon Tonge, Simon de Lusignan, Gayatri Amirthalingam
Journal: Journal of Infection (2022)
Publisher Correction: Tcf1 preprograms the mobilization of glycolysis in central memory CD8+ T cells during recall responses
Authors: Qiang Shan, Shengen Shawn Hu, Shaoqi Zhu, Xia Chen, Vladimir P. Badovinac, Weiqun Peng, Chongzhi Zang, Hai-Hui Xue
Journal: Nature Immunology (2022)
Recent updates on innovative approaches to overcome drug resistance for better outcomes in cancer
Authors: Madhu Sharma, Avijit Kumar Bakshi, Naresh Mittapelly, Shalini Gautam, Disha Marwaha, Nikhil Rai, Neha Singh, Pratiksha Tiwari, Neha Agarwal, Ankit Kumar, Prabhat Ranjan Mishra
Journal: Journal of Controlled Release (2022)
Rising costs spell disaster for the nation’s health
Authors: Neena Modi
Journal: BMJ (2022)

Rising costs spell disaster for the nation's healthNeena Modi presidentprofessor of neonatal medicine 1, 2 Black storm clouds are hanging over the nation this April as inflation rockets, national insurance rises, and the energy price cap lifts-unleashing escalating energy prices across the UK.This perfect storm of rising costs will disproportionately impact the health of the poorest in society, adding to already unacceptably wide inequalities in the UK.Energy bills are expected to rise by almost £700 this year for a typical household.Shockingly, this means that energy bills are expected to rise by more than 50%.This is five times the previous biggest increase of £139, which only came into effect in October last year.As a result, more than one in four households in the UK will be living in fuel poverty.
Considering Organismal Physiology in Laboratory Studies of Rodent Behavior
Authors: Patricia Rubio Arzola, Rebecca M. Shansky
Journal: Annual Review of Neuroscience (2022)

Any experiment conducted in a rodent laboratory is done so against the backdrop of each animal's physiological state at the time of the experiment. This physiological state can be the product of multiple factors, both internal (e.g., animal sex, strain, hormone cycles, or circadian rhythms) and external (e.g., housing conditions, social status, and light/dark phases). Each of these factors has the potential to influence experimental outcomes, either independently or via interactions with others, and yet there is little consistency across laboratories in terms of the weight with which they are considered in experimental design. Such discrepancies—both in practice and in reporting—likely contribute to the perception of a reproducibility crisis in the field of behavioral neuroscience. In this review, we discuss how several of these sources of variability can impact outcomes within the realm of common learning and memory paradigms.
Effect of Plasma and Blood Donations on Levels of Perfluoroalkyl and Polyfluoroalkyl Substances in Firefighters in Australia
Authors: Robin Gasiorowski, Miriam K. Forbes, Gabriel Silver, Yordanka Krastev, Brenton Hamdorf, Barry Lewis, Michael Tisbury, Merrole Cole-Sinclair, Bruce P. Lanphear, Roger A. Klein, Nigel Holmes, Mark Patrick Taylor
Journal: JAMA Network Open (2022)

Elevated levels of blood perfluoroalkyl and polyfluoroalkyl substances (PFASs) have been associated with a range of adverse health outcomes. Firefighters have been exposed to PFASs in firefighting foams and have previously been shown to have higher PFAS levels in blood samples than the general population. No interventions have been shown to reduce PFAS levels.