tbuckley/cabot-search huggingface dataset:
Odontogenesis-related developmental microenvironment facilitates deciduous dental pulp stem cell aggregates to revitalize an avulsed tooth
Authors: Hao Guo, Bei Li, Meiling Wu, Wanmin Zhao, Xiaoning He, Bingdong Sui, Zhiwei Dong, Ling Wang, Songtao Shi, Xiaoyao Huang, Xuemei Liu, Zihan Li, Xiaohe Guo, Kun Xuan, Yan Jin
Journal: Biomaterials (2021)

Harnessing developmental processes for tissue engineering represents a promising yet challenging approach to regenerative medicine. Tooth avulsion is among the most serious traumatic dental injuries, whereas functional tooth regeneration remains uncertain. Here, we established a strategy using decellularized tooth matrix (DTM) combined with human dental pulp stem cell (hDPSC) aggregates to simulate an odontogenesis-related developmental microenvironment. The bioengineered teeth reconstructed by this strategy regenerated three-dimensional pulp and periodontal tissues equipped with vasculature and innervation in a preclinical pig model after implantation into the alveolar bone. These results prompted us to enroll 15 patients with avulsed teeth after traumatic dental injuries in a pilot clinical trial. At 12 months after implantation, bioengineered teeth led to the regeneration of functional teeth, which supported continued root development, in humans. Mechanistically, exosomes derived from hDPSC aggregates mediated the tooth regeneration process by upregulating the odontogenic and angiogenic ability of hDPSCs. Our findings suggest that odontogenic microenvironment engineering by DTM and stem cell aggregates initiates functional tooth regeneration and serves as an effective treatment for tooth avulsion.
The Cell‐Isolation Capsules with Rod‐Like Channels Ensure the Survival and Response of Cancer Cells to Their Microenvironment
Authors: Lanlan Hui, Deng Wang, Zhao Liu, Yueqi Zhao, Zhongzhong Ji, Man Zhang, Helen He Zhu, Wenqing Luo, Xiaomu Cheng, Liming Gui, Wei‐Qiang Gao
Journal: Advanced Healthcare Materials (2021)

Current macrocapsules with semipermeable but immunoprotective polymeric membranes are attractive devices to achieve the purpose of immunoisolation, however, their ability to allow diffusion of essential nutrients and oxygen is limited, which leads to a low survival rate of encapsulated cells. Here, a novel method is reported by taking advantage of thermotropic liquid crystals, sodium laurylsulfonate (SDS) liquid crystals (LCs), and rod-like crystal fragments (LCFs) to develop engineered alginate hydrogels with rod-like channels. This cell-isolation capsule with an engineered alginate hydrogel-wall allows small molecules, large molecules, and bacteria to diffuse out from the capsules freely but immobilizes the encapsulated cells inside and prevents cells in the microenvironment from moving in. The encapsulated cells show a high survival rate with isolation of host immune cells and long-term growth with adequate nutrients and oxygen supply. In addition, by sharing and responding to the normal molecular and vesicular microenvironment (NMV microenvironment), encapsulated cancer cells display a transition from tumorous phenotypes to ductal features of normal epithelial cells. Thus, this device will be potentially useful for clinical application in cell therapy by secreting molecules and for establishment of patient-derived xenograft (PDX) models that are often difficult to achieve for certain types of tumors, such as prostate cancer.
Effects of RGD-grafted phosphatidylserine-containing liposomes on the polarization of macrophages and bone tissue regeneration
Authors: Lele Wu, Yongjoon Kim, Gyeung Mi Seon, Sang Hoon Choi, Hee Chul Park, Gitae Son, Soung Min Kim, Bum-Soon Lim, Hyeong-Cheol Yang
Journal: Biomaterials (2021)
Abstract 197: Function of Endothelial Progenitor Cell alpha2 beta1 and alpha5 beta1 Integrins in Repair of Endothelial Barrier and Neovascularization
Authors: Kishore K Wary, Myla Patterson, Yidan Zhao, Asrar B Malik
Journal: Circulation (2006)

We addressed mechanisms by which mobilization of EPCs mediates vascular endothelial barrier repair and neovascularization. We tested the hypothesis that these processes require integrin-mediated ce...
Digital medicine and the curse of dimensionality
Authors: Visar Berisha, Chelsea Krantsevich, P. Richard Hahn, Shira Hahn, Gautam Dasarathy, Pavan Turaga, Julie Liss
Journal: npj Digital Medicine (2021)

Abstract Digital health data are multimodal and high-dimensional. A patient’s health state can be characterized by a multitude of signals including medical imaging, clinical variables, genome sequencing, conversations between clinicians and patients, and continuous signals from wearables, among others. This high volume, personalized data stream aggregated over patients’ lives has spurred interest in developing new artificial intelligence (AI) models for higher-precision diagnosis, prognosis, and tracking. While the promise of these algorithms is undeniable, their dissemination and adoption have been slow, owing partially to unpredictable AI model performance once deployed in the real world. We posit that one of the rate-limiting factors in developing algorithms that generalize to real-world scenarios is the very attribute that makes the data exciting—their high-dimensional nature. This paper considers how the large number of features in vast digital health data can challenge the development of robust AI models—a phenomenon known as “the curse of dimensionality” in statistical learning theory. We provide an overview of the curse of dimensionality in the context of digital health, demonstrate how it can negatively impact out-of-sample performance, and highlight important considerations for researchers and algorithm designers.
TCT-166 Concomitant Mitral Regurgitation and Low-Gradient Aortic Stenosis in Patients Undergoing TAVR or SAVR—An Analysis From the German Aortic Valve Registry (GARY)
Authors: Brunilda Alushi, Stephan Ensminger, Eva Herrmann, Umniye Balaban, Andreas Beckmann, Sabine Bleiziffer, Helge Möllmann, Thomas Walther, Stephan Baldus, Volkmar Falk, Holger Thiele, Christian Frerker, Alexander Lauten
Journal: Journal of the American College of Cardiology (2021)
TCT-238 Real-World Experience With the New Watchman FLX Device: Data From Two High-Volume Sicilian Centers: The FLX-IEST Registry
Authors: Giampiero Vizzari, Marco Contarini, Paolo Mazzone, Andrea Sardone, Giulia Laterra, Marco Giuseppe Frazzetto, Maria Sanfilippo, Giorgio Sacchetta, Corrado Tamburino, Antonio Micari, Carmelo Grasso
Journal: Journal of the American College of Cardiology (2021)
Co<sub>3</sub>O<sub>4</sub> Nanowires Capable of Discharging Low Voltage Electricity Showing Potent Antibacterial Activity for Treatment of Bacterial Skin Infection
Authors: Chengnan Li, Zongshao Li, Yinxiang Zeng, Xianshuo Cao, Huimin Zhao, Yi Yan Yang, Peiyan Yuan, Xihong Lu, Xin Ding
Journal: Advanced Healthcare Materials (2021)

Overuse of antibiotics has led to multidrug resistance in bacteria, posing a tremendous challenge to the healthcare system. There is an urgent need to explore unconventional strategies to overcome this issue. Herein, for the first time, we report a capacitive Co3 O4 nanowire (NW) electrode coated on flexible carbon cloth, which is capable of eliminating bacteria while discharging, for the treatment of skin infection. Benefiting from the unique NW-like morphology, the Co3 O4 NW electrode with increased active sites and enhanced capacitive property exhibits a prominent antibacterial effect against both Gram-positive and Gram-negative bacteria after charging at a low voltage of 2 V for 30 min. Furthermore, the electrode is demonstrated to be recharged for multiple antibacterial treatment cycles without significant change of antibacterial activity, allowing for practical use in a non-clinical setting. More importantly, this Co3 O4 NW electrode is capable of damaging bacterial cell membrane and inducing the accumulation of intracellular reactive oxygen species without impairing viability of skin keratinocytes. In a mouse model of bacterial skin infection, the Co3 O4 electrode shows significant therapeutic efficacy by eradicating colonized bacteria, thus accelerating the healing process of infected wounds. This nanostructured capacitive electrode provides an antibiotic-free, rechargeable, and wearable approach to treat bacterial skin infection.
TCT-7 Two-Year Results of the OPTIMIZE IDE Trial: A Randomized Evaluation of Sirolimus-Eluting Coronary Stents With Fixed-Wire and Rapid-Exchange Delivery Systems and a Novel Bioresorbable Drug Carrier
Authors: Sunil Rao, A.J.J. IJsselmuiden, Shigeru Saito, James Zidar, S. Chiu Wong, Pieter Stella, Steven Yakubov, Dean Kereiakes
Journal: Journal of the American College of Cardiology (2021)
Contextual modulation of conditioned responses in humans: A review on virtual reality studies
Authors: Marta Andreatta, Paul Pauli
Journal: Clinical Psychology Review (2021)

Conditioned response (CRs) triggered by stimuli predicting aversive consequences have been confirmed across various species including humans, and were found to be exaggerated in anxious individuals and anxiety disorder patients. Importantly, contextual information may strongly modulate such conditioned responses (CR), however, there are several methodological boundaries in the translation of animal findings to humans, and from healthy individuals to patients. Virtual Reality (VR) is a useful technological tool for overcoming such boundaries. In this review, we summarize and evaluate human VR conditioning studies exploring the role of the context as conditioned stimulus or occasion setter for CRs. We observe that VR allows successful acquisition of conditioned anxiety and conditioned fear in response to virtual contexts and virtual cues, respectively. VR studies also revealed that spatial or temporal contextual information determine whether conditioned anxiety and conditioned fear become extinguished and/or return. Novel contexts resembling the threatening context foster conditioned fear but not conditioned anxiety, suggesting distinct context-related generalization processes. We conclude VR contexts are able to strongly modulate CRs and therefore allow a comprehensive investigation of the modulatory role of the context over CR in humans leading to conclusions relevant for non-VR and clinical studies.
<i>Asxl1</i> loss cooperates with oncogenic <i>Nras</i> in mice to reprogram the immune microenvironment and drive leukemic transformation
Authors: Xiaona You, Fabao Liu, Moritz Binder, Alexis Vedder, Terra Lasho, Zhi Wen, Xin Gao, Evan Flietner, Adhithi Rajagopalan, Yun Zhou, Christy Finke, Abhishek Mangaonkar, Ruiqi Liao, Guangyao Kong, Erik A. Ranheim, Nathalie Droin, Anthony M. Hunter, Sergey Nikolaev, Maria Balasis, Omar Abdel-Wahab, Ross L. Levine, Britta Will, Kalyan Vara Ganesh Nadiminti, David Yang, Klaus Geissler, Eric Solary, Wei Xu, Eric Padron, Mrinal M. Patnaik, Jing Zhang
Journal: Blood (2021)
Age- and Sex-Specific Incidence of Cerebral Venous Sinus Thrombosis Associated With Ad26.COV2.S COVID-19 Vaccination
Authors: Aneel A. Ashrani, Daniel J. Crusan, Tanya Petterson, Kent Bailey, John A. Heit
Journal: JAMA Internal Medicine (2021)

With vaccination rates lagging in areas with higher social vulnerability, small financial incentives should be considered in conjunction with other equity-promoting strategies. 5,6 The social incentive of cash cards for drivers may also encourage people to help get their friends and family vaccinated, a powerful motivator for those undecided about vaccination.With hundreds of millions of dollars being spent to accelerate COVID-19 vaccine uptake, these study findings suggest that this strategy for increasing vaccination merits greater investment.
TCT-113 Ten-Year Survival Benefit and Appropriateness of Surgical or Percutaneous Revascularization Based on Individual Predicted All-Cause Mortality in Patients With Complex Coronary Artery Disease
Authors: Patrick Serruys, Mohanad Hamandi, Chao Gao, Hironori Hara, Scot Garg, David van Klaveren, David Kent, Ewout W. Steyerberg, Yoshinobu Onuma, Daniel Thuijs, Piroze Davierwala, Arie Kappetein, David Holmes, Marie-Claude Morice, Bruce Lytle, Friedrich-Wilhelm Mohr, Michael Mack
Journal: Journal of the American College of Cardiology (2021)
Effect of carbon nanomaterial dimension on the functional activity and degeneration of neurons
Authors: Hyojin Lee, Seongchan Kim, Kyeong Seob Hwang, Nu Ri Lim, Han Bin Oh, Il-Joo Cho, Jongbaeg Kim, Ki Hun Kim, Hong Nam Kim
Journal: Biomaterials (2021)

Despite growing concerns regarding the threat of airborne nanoparticle-mediated brain degeneration, the underlying pathological mechanisms remain unclear. Carbon nanomaterials, the main components of airborne nanoparticles, have multi-dimensional structures. Therefore, the dimensional effect of carbon-based nanomaterials on the regulation of neural function in brain disorders requires additional clarification. Herein, we report the interaction between zero-to three-dimensional carbon nanostructures and the amyloid-beta protein, which can either activate or interrupt neuronal functions, depending on the dimension of the carbon nanostructures. The carbon nanomaterials induced significant cellular activation by short-term exposure, while prolonged exposure eventually caused neuronal cell death. Such dimension-dependent activation or degeneration was more evident in the higher-dimension carbon nanomaterials, as confirmed by the increases in neurotransmitter secretion and synapse-related protein levels to more than five times at 72 h of monitoring and calcium signaling in the neurons. The inclusion of amyloid-beta proteins ameliorated the cytotoxic effects of carbon nanomaterials in higher-dimensional carbon nanomaterials by regulating 333 genes. We found that the ɑ-synuclein gene is the key factor in carbon-induced abnormal neuronal function. Therefore, through biological analyses and in vitro feasibility studies, this new insight may contribute toward understanding the pathological mechanism and finding a new target for therapy in human brain pathologies.
TCT-331 Long-Term Follow-Up Clinical Outcomes of Primary Percutaneous Coronary Intervention in Left Main Coronary Artery Disease
Authors: Ricardo Concepcion-Suárez, Ignacio Sanchez-Perez, Alfonso Freites Esteves, Fernando Lozano, Jorge Martinez del Río, Alfonso Morón Alguacil, Manuel Muñoz Garcia, Daniel Aguila-Gordo, Martin Negreira, Ariana Gonzálvez-García
Journal: Journal of the American College of Cardiology (2021)
TCT-204 Consequences of Covid-19 Policy on Myocardial Infarction Reperfusion Therapy and Prognosis in a High-Volume PCI Center in Chile
Authors: Pabla Cataldo, Fernando Verdugo, Christian Dauvergne, Manuel Mendez, Fernando Pineda, Polentzi Uriarte, Jorge Sandoval
Journal: Journal of the American College of Cardiology (2021)
THE PRESENCE OF A TRUNCATING MUTATION IN ABCB11 ABROGATES THE BENEFICIAL EFFECT OF A RESIDUAL FUNCTION MUTATION ON THE COURSE OF SEVERE BILE SALT EXPORT PUMP DEFICIENCY
Authors: Antonia Felzen, Daan van Wessel, Richard J. Thompson, Emmanuel M. Gonzales, Irena Jankowska, Benjamin L. Shneider, Etienne Sokal, Tassos Grammatikopoulos, Agustina Kadaristiana, Emmanuel Jacquemin, Anne Spraul, Patryk Lipinski, Piotr Czubkowski, Nathalie Rock, Mohammad Shagrani, Dieter Broering, Talal Algoufi, Nejat Mazhar, Emanuele Nicastro, Deirdre Kelly, Gabriella Nebbia, Henrik Arnell, Bjorn Fischler, Jan Hulscher, Daniele Serranti, Cigdem Arikan, Esra Polat, Dominique Debray, Florence Lacaille, Cristina Goncalves, Loreto Hierro, Gema Munoz Bartolo, Yael Mozer-Glassberg, Amer Azaz, Jernej Brecelj, Antal Dezsofi, Pier Luigi Calvo, Enke Grabhorn, Steffen Hartleif, Wendy Van der Woerd, Binita M. Kamath, Jian-She Wang, Liting Li, Ozlem Durmaz, Nanda Kerkar, Marianne Horby Jorgensen, Ryan T. Fischer, Carolina Jimenez-Rivera, Seema Alam, Mara Cananzi, Mathias Ruiz, Cristina Targa Ferreira, Felipe Ordonez Ferrero, Heng Wang, Valerie Sency, Kyung Mo Kim, Huey-Ling Chen, Elisa Carvalho, Alexandre Fabre, Jesus Quintero Bernabeu, Estella M. Alonso, Ronald J. Sokol, Frederick J. Suchy, Kathleen M. Loomes, Patrick James McKiernan, Philip Rosenthal, Yumirle Turmelle, Simon P. Horslen, Kathleen B. Schwarz, Jorge A. Bezerra, Kasper S. Wang, Bettina E. Hansen, Henkjan J. Verkade
Journal: Hepatology (2020)
High‐Throughput On‐Chip Human Mesenchymal Stromal Cell Potency Prediction
Authors: Rebecca S. Schneider, Alexandra C. Vela, Evelyn Kendall Williams, Karen E. Martin, Wilbur A. Lam, Andrés J. García
Journal: Advanced Healthcare Materials (2021)

Human mesenchymal stromal cells (hMSCs) are a promising source for regenerative cell therapy. However, hMSC clinical use has been stymied by product variability across hMSC donors and manufacturing practices resulting in inconsistent clinical outcomes. The inability to predict hMSC clinical efficacy, or potency, is a major limitation for market penetration. Standard metrics of hMSC potency employ hMSCs and third-party immune cell co-cultures, however, these assays face translational challenges due to third-party donor variability and lack of scalability. While surrogate markers of hMSC potency have been suggested, none have yet had translational success. To address this, a high-throughput, scalable, low-cost, on-chip microfluidic potency assay is presented with improved functional predictive power and recapitulation of in vivo secretory responses compared to traditional approaches. Comparison of hMSC secretory responses to functional hMSC-medicated immune cell suppression demonstrates shortcomings of current surrogate potency markers and identifies on-chip microfluidic potency markers with improved functional predictive power compared to traditional planar methods. Furthermore, hMSC secretory performance achieved in the on-chip microfluidic system has improved similarity compared to an in vivo model. The results underscore the shortcomings of current culture practices and present a novel system with improved functional predictive power and hMSC physiological responses.
Virtual Pediatric Systems: AKI in Pediatric COVID-19 Among North American Intensive Care Units
Authors: Rupesh Raina, Ronith Chakraborty, Siddhartha S. Singh, Shefali Mahesh
Journal: Journal of the American Society of Nephrology (2021)

Background: There is a dearth of large-scale studies assessing the extent of Acute Kidney Injury (AKI) in pediatric COVID-19 patients. We aim to identify the epidemiology and associated risk factors of AKI in the pediatric COVID population through the Virtual Pediatric Systems (VPS) database. Methods: We performed a retrospective analysis on 2,597 COVID-19 pediatric patients (≤ 24 years) in the VPS COVID-19 database including both males and females with a positive status of SARS-CoV-2 infection, ICU admission, and AKI diagnosis for the AKI group using ICD-10 codes. Variables included in the analyses covered demographics, diagnosis, lab order/results, treatment modalities, length of stay, and mortality. Categorical variables were summarized as percentages while continuous variables as medians. We utilized univariate analysis and multivariate linear regression to assess the differences between the patient group with AKI and those without. Results: An AKI incidence of 10.7% (297/2597) was found within the pediatric cohort. The AKI group had a significantly higher median hospital length of stay (9.1 days vs. 5.1), PIM2 and PIM3 probability of death (1.2 vs. 0.96 and 0.99 vs. 0.78, respectively), and proportion of mortality (7.5% vs. 1.6%) in comparison to the non-AKI group. Similarly, the AKI group experienced higher rates of interventions in comparison to the non-AKI group such as vascular access (67.0% vs. 29.8%), airway/respiratory support (55.9% vs. 43.8%), renal support (5.4% vs. 0.4%), and cardio-respiratory support (2.9% vs. 0.8%). Conclusions: AKI is a severe complication of COVID-19 in children and adolescents. Our study suggests a 4.7-fold increase in mortality in the COVID-19 AKI group. Pediatric COVID-19 patients should be monitored for AKI development and necessitate analyses on manifestations of COVID-19 to improve health outcomes.
Systematic Review of Counseling and Behavioral Interventions for Healthy Weight and Weight Gain in Pregnancy From the US Preventive Services Task Force
Authors: Jodie M. Dodd, Kathryn Dalrymple, Jennie Louise
Journal: JAMA (2021)

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Thyroid Incidentaloma on 68Ga-PSMA-11 PET/CT Leading to Detection of Thyroid Metastasis in Metastatic Prostate Carcinoma
Authors: Rahul V. Parghane, Sandip Basu
Journal: Clinical Nuclear Medicine (2021)

68Ga-labeled prostate-specific membrane antigen (PSMA)-11 PET/CT has evolved as the noninvasive imaging modality of choice in prostatic adenocarcinoma to detect overexpression of PSMA on prostate cancer cells. Metastasis to the thyroid gland is rarely observed in clinical practice of prostatic adenocarcinoma. Herein, we report the first and rare case of metastatic castration-resistant prostatic adenocarcinoma with thyroid metastasis. The patient demonstrated intensely PSMA-expressing primary prostatic lesion, metastatic lymph nodes, and skeletal lesions, and also mild uptake in thyroid nodule, which on further investigations was established as thyroid metastasis from prostate adenocarcinoma.
Effects of a Partially Supervised Conditioning Program in Cystic Fibrosis: An International Multicenter, Randomized Controlled Trial (ACTIVATE-CF)
Authors: Helge Hebestreit, Susi Kriemler, Christian Schindler, Lothar Stein, Chantal Karila, Don S. Urquhart, David M. Orenstein, Larry C. Lands, Jonathan Schaeff, Ernst Eber, Thomas Radtke, Ernst Eber, Marlies Wagner, Helmut Ellemunter, Nancy Alarie, Clotilde Simon, Anne Faucou, Laurent Mely, Bruno Ravaninjatovo, Anne Prevotat, Cordula Koerner-Rettberg, Jutta Hammermann, Christina Smaczny, Inka Held, Sibylle Junge, Oliver Nitsche, Rainald Fischer, Jörg Große-Onnebrink, Anne Wesner, Andreas Hector, Alexandra Hebestreit, Christian Benden, Carmen Casaulta, Reta Fischer, Alexander Möller, Erik Hulzebos, Marcella Burghard, Sarah Blacklock, Debbie Miller, Zoe Johnstone, John D. Lowman
Journal: American Journal of Respiratory and Critical Care Medicine (2021)

The long-term effects of vigorous physical activity (PA) on lung function in cystic fibrosis are unclear.
EDP-305 in patients with NASH: A phase II double-blind placebo-controlled dose-ranging study
Authors: Vlad Ratziu, Mary E. Rinella, Brent A. Neuschwander-Tetri, Eric Lawitz, Douglas Denham, Zeid Kayali, Aasim Sheikh, Kris V. Kowdley, Taddese Desta, Magdy Elkhashab, Jeffery DeGrauw, Bryan Goodwin, Alaa Ahmad, Nathalie Adda
Journal: Journal of Hepatology (2021)