tbuckley/cabot-search huggingface dataset:
Annals Graphic Medicine - The PPE Monsters: A Pediatric Patient With COVID-19
Authors: Nour Houbby, Arwa Hagana, Ridhaa Remtulla
Journal: Annals of Internal Medicine (2020)

Web Exclusives21 July 2020Annals Graphic Medicine - The PPE Monsters: A Pediatric Patient With COVID-19FREENour Houbby, Arwa Hagana, and Ridhaa RemtullaNour HoubbyImperial College London, London, United Kingdom (N.H., A.H.)Search for more papers by this author, Arwa HaganaImperial College London, London, United Kingdom (N.H., A.H.)Search for more papers by this author, and Ridhaa RemtullaUniversity of Birmingham, Birmingham, United Kingdom (R.R.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/G20-0063 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Download figure Download PowerPoint Author, Article, and Disclosure InformationAuthors: Nour Houbby; Arwa Hagana; Ridhaa RemtullaAffiliations: Imperial College London, London, United Kingdom (N.H., A.H.)University of Birmingham, Birmingham, United Kingdom (R.R.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=G20-0063.Author/Illustrator Information: Nour Houbby (nour.houbby16@imperial.ac.uk), Arwa Hagana (e-mail, Stwadell2018@health.fau.edu), and Ridhaa Remtulla (e-mail, RXR529@student.bham.ac.uk).This article was published at Annals.org on 21 July 2020. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 18 August 2020Volume 173, Issue 4 Page: W75-W76 Keywords COVID-19 Disclosure Health care Personal protective equipment ePublished: 21 July 2020 Issue Published: 18 August 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Hand measurements in ankylosing spondylitis.
Authors: J Harris, D M Chaput de Saintonge, C G Barnes
Journal: Annals of the Rheumatic Diseases (1973)

OBJECTIVE: To describe and compare the relative attributes (reliability, ease of use, applicability, and relevance) of different assessment tools for economic analyses as they pertain to rheumatoid arthritis (RA) literature. METHODS: An expert panel, comprising rheumatology researchers and clinicians, operationalized 2 economic appraisal instruments and applied them to 11 articles used for analysis. Each expert reviewed 3 articles, with each article independently reviewed by a pair of experts. A summary score for each article per appraisal instrument was calculated by dividing the number of items that received a "positive" response by the total number of items in the appraisal instrument. RESULTS: Scores for each article were similar across reviewers and appraisal instruments. CONCLUSION: There is a need for a more comprehensive approach for evaluating this rapidly growing body of economic literature that is not only valid and reliable, but also easy to apply and understand. Although consistency between reviewers was good on both guidelines, inter-guideline discrepancies were noted and reviewers reported some difficulty in using the operationalized format.
Effectiveness of the BNT162b2 Vaccine after Recovery from Covid-19
Authors: Ariel Hammerman, Ruslan Sergienko, Michael Friger, Tanya Beckenstein, Alon Peretz, Doron Netzer, Shlomit Yaron, Ronen Arbel
Journal: New England Journal of Medicine (2022)

The risk of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) decreases substantially among patients who have recovered from coronavirus disease 2019 (Covid-19). However, it is unknown how long protective immunity lasts. Current guidelines recommend vaccination of recovered patients even though data regarding vaccine effectiveness in such cases are still limited.
Hematopoietic stem cell transplantation chemotherapy causes microglia senescence and peripheral macrophage engraftment in the brain
Authors: Kurt A. Sailor, George Agoranos, Sergio López-Manzaneda, Satoru Tada, Beatrix Gillet-Legrand, Corentin Guerinot, Jean-Baptiste Masson, Christian L. Vestergaard, Melissa Bonner, Khatuna Gagnidze, Gabor Veres, Pierre-Marie Lledo, Nathalie Cartier
Journal: Nature Medicine (2022)

Hematopoietic stem cell transplantation (HSCT) is a therapy used for multiple malignant and nonmalignant diseases, with chemotherapy used for pretransplantation myeloablation. The post-HSCT brain contains peripheral engrafted parenchymal macrophages, despite their absence in the normal brain, with the engraftment mechanism still undefined. Here we show that HSCT chemotherapy broadly disrupts mouse brain regenerative populations, including a permanent loss of adult neurogenesis. Microglial density was halved, causing microglial process expansion, coinciding with indicators of broad senescence. Although microglia expressed cell proliferation markers, they underwent cell cycle arrest in S phase with a majority expressing the senescence and antiapoptotic marker p21. In vivo single-cell tracking of microglia after recovery from chemical depletion showed loss of their regenerative capacity, subsequently replaced with donor macrophages. We propose that HSCT chemotherapy causes microglial senescence with a gradual decrease to a critical microglial density, providing a permissive niche for peripheral macrophage engraftment of the brain. Hematopoietic stem cell transplantation chemotherapy with busulfan causes senescence of brain microglia, rapid loss of adult neurogenesis and engraftment of peripheral donor macrophages into the brain of mice post transplantation.
ANAESTHETIC EXPLOSIONS
Authors: K. B. Pinson
Journal: BMJ (1930)

ANAESTHETIC EXPLOSIONS.[I DI JnTxuA hvpo-acsthesia in cases of pruritus is very satisfactory.The pelcailne contenit in 10 c.cm. of this soltution (0.05 gram) is well within the limits of safety for adults, and I hav-e only once had any general reaction: this was in the case of a
Prescription charges.
Authors: K. B. Hallam
Journal: BMJ (1968)

BaJourhave worked in Indonesia, Uganda, and Korea.Barred from surgery in the United Kingdom, in Indonesia I found myself in sole charge of a 300-bedded hospital with around 200 outpatients a day, responsible for the surgery, medicine, obstetrics, etc., for a population of 45,000 persons, the only doctor in a large tract of land.Thus it is interesting to note that the Interview Board believes that non-specialists who undertake surgery add considerably to their income and interest, but that it "cannot always be in the best interest of the patients."I agree that the practice of surgery adds to one's interest, but working for the impoverished Indonesians I considered myself fortunate to receive the equivalent of 7s.6d. for a radical mastectomy.Further, I wonder on what
Laburnum Poisoning
Authors: C. G. Wheelhouse
Journal: BMJ (1870)

THE BRITISH MEDICAL YOURNAL.79 specific.Iodide of potassium was ordered, and the ulcer was touched with the solid nitrate of silver.The patient was requested to fre- quently steam his throat.Little alteration in the voice, took place for some time, but, under a continuation of the medicine, and a change of the local application from nitrate of silver to a solution of chloride of zinc (two scruples to the ounce) the disease was entirely cured in two months.
Test Taker
Authors: Ellis Knight
Journal: Annals of Internal Medicine (2007)

Ad Libitum3 July 2007Test TakerEllis Knight, MDEllis Knight, MDFrom Palmetto Health Richland, Columbia, SC 29203.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-147-1-200707030-00009 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail So much easier then,A, B, all of the above. Notwe want you to do “everything”,You know, “She's a fighter”.No multiple choices,No one best answer,Order out of chaos,Smartest in the class, once.Still with questions. Butno blanks to fill,The no. 2 useless,No way to pass.Subjective, essay questions.Graded on a curve, impossible to know.No satisfaction. No nice and neat.Final grade, incomplete. Author, Article, and Disclosure InformationAffiliations: From Palmetto Health Richland, Columbia, SC 29203.Current Author Address: Ellis Knight, MD, Palmetto Health Richland, Five Medical Park Road, Columbia, SC 29203. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 3 July 2007Volume 147, Issue 1Page: 57 ePublished: 3 July 2007 Issue Published: 3 July 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract 17195: Accuracy of Fetal Echocardiography in the Current Era
Authors: Kim L Haberer, Angela McBrien, Aisling Young, Winnie Savard, Luke Eckersley, Timothy Colen, Lisa K Hornberger
Journal: Circulation (2018)

Accuracy of Fetal Echocardiography in Defining Anatomical Details of Fetal Cardiac Pathology in the Current Era Background: Enhanced ultrasound technology and improvements in prenatal detection have provided opportunities to fine-tune fetal cardiac diagnoses. We sought to determine the accuracy of fetal echocardiography in defining anatomical details of major structural fetal heart disease(FHD) Methods: We queried the fetal echo database at the University of Alberta to identify pregnancies with a major FHD diagnosis between 2007-2018. We excluded simple septal defects, minor valve abnormalities and isolated coarctation. FHD was divided into 12 major categories to examine differences within subtypes. Fetal echocardiography reports were compared to post-natal echocardiography or autopsy when available, to assess segmental anatomy. Differences were described according to the following categories:1) No difference between fetal and postnatal findings 2) Minor differences with no impact on outcome (left superior vena cava), 3) Minor differences that could make a minor difference to the delivery plan or surgery (e.g. vascular ring), 4) Major differences that could lead to a change in the course of pregnancy, delivery or surgical planning (e.g. ductal dependency); 5) Errors of categorization that did not alter surgical planning but could have changed counseling (e.g. associations with extra-cardiac pathology). Results: In the study period 744 pregnancies with major FHD were encountered of which 151 (20.3%) had pregnancy termination, 43(6%) intrauterine demise, 6(1%) were lost to followup. 524(71%) were liveborn. Of the 744, 542 (524 echo and 18 autopsy) had confirmation of full cardiac anatomy. Table 1 details the number of cases in whom differences were demonstrated. Conclusion: Fetal echocardiography in the current era is highly accurate with few serious errors. Delineating the anatomy of the outflow tracts in complex cardiac lesions remains a challenge
Acute Porphyria
Authors: M. G. Good
Journal: BMJ (1948)

Inclusion Bodies of the Erythrocyte SIR-With reference to your annotation (Aug.28, p. 431) entitled " Inclusion Bodies of the Erythrocyte," we should be obliged if you would allow us to refute an opinion you attribute to us.Referring to our publication on this subject you state, "They are convinced that the siderotic granules of Gruineberg are different from the Pappenheimer bodies.This is, indeed, a complete misrepresentation of our views, for on page 255 of the paper referred to' we stated, " In view of these considerations it would appear that the siderotic granules described by Gruneberg (1941a and b, 1942) and by Doniach et al. (1943) are probably fundamentally similar to the Pappen- heimer bodies."On the other hand, we wish to emphasize our belief that these inclusion bodies, which stain with Romanowsky stains and give a direct positive reaction with potassium ferrocyanide and hydrochloric acid, are fundamentally dissimilar from the siderotic granules described by Case.2 ' 4 The arguments supporting this belief were discussed in our paper, but it may be mentioned here that Case's granules differ in respect of occurrence, morphology, and staining reactions from the erythrocytic inclusions described by Gruneberg in curly-tailed mice, and by Pappenheimer et al. and by ourselves' in man.Your annotation also refers to our having collected some evidence that the granules of basophilic stippling due to lead poisoning are similar to Pappenheimer bodies.It may be of interest to note that we have extended our studies in this field and have confirmed that the basophilic granules of lead poisoning present many similarities to the Pappenheimer bodies as regards development, staining reactions in the bone marrow and in the peripheral blood, and the effect of splenectomy.
How Cancer Will Affect the US in 2022
Authors: Melissa Suran
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 355: Performance of Inclusion and Exclusion Criteria Based on Prognosis in an Interventional Out-of-Hospital Cardiac Arrest Study
Authors: Nick Krehel, Clifton W Callaway, Ankur Doshi, Jonathan Elmer, Francis X Guyette, Masashi Okubo, Alexandra Weissman, Jon C Rittenberger, Cameron Dezfulian
Journal: Circulation (2018)

Introduction: Selection of out-of-hospital cardiac arrest (OHCA) patients for inclusion in randomized control trials (RCT) presents a challenge. The goal is to enroll patients with severe injury warranting intervention yet exclude those with extreme irreversible disease. Selection early after return of spontaneous circulation (ROSC) is complicated by a relative paucity of prognostic variables. We examined the accuracy of enrollment criteria in the iNO OHCA study (NCT03079102) in excluding patients likely to have good or poor outcomes within three hours (3h) of ROSC. Methods: OHCA patients arriving to two tertiary care centers in Pittsburgh were screened within 3h of ROSC. We excluded subjects that followed commands (good prognosis expected) and subjects expected to have poor prognosis based on: Full Outline of UnResponsiveness Brainstem (FOUR B) score &lt;2; CPR time &gt;40 min; investigator estimate of &gt;95% mortality; CT evidence of cerebral edema or intracranial hemorrhage; clinical evidence of myoclonic status epilepticus; or traumatic OHCA etiology. We also excluded subjects not within 3h of ROSC. We compared discharge survival and good neurologic outcome based on disposition (location). Results: Over a nine-month period we screened 155 patients with ROSC following OHCA, 20 subjects (13%) were included in the study and 135 (87%) were excluded ( Table ). The odds ratio (OR) of survival if excluded for poor prognosis was 0.03 (95% CI: 0.01 - 0.08) and worsened when &gt;1 criteria were met. Exclusion for good prognosis was associated with improved survival (OR = 67.2 [95% CI: 14.3 - 316.3]). Conclusions: Our criteria reliably exclude OHCA subjects with good or poor prognosis within 3h of ROSC, yielding a study population with intermediate survival which can be applicable to future OHCA trials. Our criteria selected a minority (13%) of OHCA patients likely to benefit from intervention while reserving resources.
Targeting angiogenic growth factors using therapeutic glycosaminoglycans on doppel-expressing endothelial cells for blocking angiogenic signaling in cancer
Authors: Jeong Uk Choi, Xiaojun Zhang, Md Mahedi Hasan, Mazharul Karim, Seung Woo Chung, Farzana Alam, Faleh Alqahtani, Sireesha Y. Reddy, In-San Kim, Taslim A. Al-Hilal, Youngro Byun
Journal: Biomaterials (2022)
An IL-9–pulmonary macrophage axis defines the allergic lung inflammatory environment
Authors: Yongyao Fu, Jocelyn Wang, Baohua Zhou, Abigail Pajulas, Hongyu Gao, Baskar Ramdas, Byunghee Koh, Benjamin J. Ulrich, Shuangshuang Yang, Reuben Kapur, Jean-Christophe Renauld, Sophie Paczesny, Yunlong Liu, Robert M. Tighe, Paula Licona-Limón, Richard A. Flavell, Shogo Takatsuka, Daisuke Kitamura, Robert S. Tepper, Jie Sun, Mark H. Kaplan
Journal: Science Immunology (2022)

Despite IL-9 functioning as a pleiotropic cytokine in mucosal environments, the IL-9–responsive cell repertoire is still not well defined. Here, we found that IL-9 mediates proallergic activities in the lungs by targeting lung macrophages. IL-9 inhibits alveolar macrophage expansion and promotes recruitment of monocytes that develop into CD11c + and CD11c − interstitial macrophage populations. Interstitial macrophages were required for IL-9–dependent allergic responses. Mechanistically, IL-9 affected the function of lung macrophages by inducing Arg1 activity. Compared with Arg1-deficient lung macrophages, Arg1-expressing macrophages expressed greater amounts of CCL5. Adoptive transfer of Arg1 + lung macrophages but not Arg1 − lung macrophages promoted allergic inflammation that Il9r −/− mice were protected against. In parallel, the elevated expression of IL-9, IL-9R, Arg1, and CCL5 was correlated with disease in patients with asthma. Thus, our study uncovers an IL-9/macrophage/Arg1 axis as a potential therapeutic target for allergic airway inflammation.
Gel improves visibility despite post-prandial timing of endoscopy for accidental ingestion
Authors: Tadashi Ochiai, Masaki Ominami, Yasuaki Nagami, Taku Manabe, Mitsuhiro Kono, Shusei Fukunaga, Yasuhiro Fujiwara
Journal: Endoscopy (2022)

Urgent therapeutic endoscopy is recommended for foreign bodies lodged in the upper gastrointestinal tract such as sharp and pointed objects, magnets, batteries, and large or long objects [1]. However, endoscopic foreign body extraction is sometimes difficult and time-consuming due to copious food residue. Gel immersion endoscopy is useful in securing the visual field from residue and bleeding [2] [3]. Here, we report the implementation of gel immersion endoscopy with enhanced visualization of a foreign body in the stomach, despite being filled with residue.
Use of Trifluridine/Tipiracil and Oxaliplatin as Induction Chemotherapy in Resectable Esophageal and Gastroesophageal Junction Adenocarcinoma
Authors: Sarbajit Mukherjee, Sarah Chatley
Journal: Journal of the National Comprehensive Cancer Network (2021)

This is an open-label, multicenter, phase II study of trifluridine/tipiracil (FTD/TPI) administered with oxaliplatin before chemoradiation in patients with adenocarcinoma of the esophagus or gastroesophageal junction (GEJ).Patients meeting inclusion criteria will receive 3 cycles of FTD/TPI (35 mg/m 2 twice daily) and oxaliplatin (85 mg/m 2 ) before undergoing concurrent chemoradiation (standard-of-care radiation dose of 5,040 cGy will be used at all participating study sites) with carboplatin (area under the curve, 2) and paclitaxel (50 mg/m 2 ) for 6 weeks, followed by surgery.FTD/TPI will be self-administered (in tablet form) twice daily by study participants and documented in the provided drug diary.In this study, circulating tumor DNA (ctDNA) levels will be collected at 5 different time points: at diagnosis, after completion of induction chemotherapy, after completion of chemoradiation, after surgery, and at the time of disease recurrence, if this occurs.The aim is to correlate the ctDNA level with disease recurrence and metabolic response on PET/CT.Accrual is expected to take 24 months (N545) with an additional 12 months of follow-up on study.After completion of 1 year of on-study follow-up, patients will be followed (monitored for survival status) as per standard of care: year 1 through year 2, every 3 to 6 months, every 6 to 12 months for 3 to 5 years, and then annually until disease progression or death, whichever occurs first.Estimated time frame for analysis of the primary endpoint is approximately 3 years after study commencement.
Praktisches Lehrbuch der Kindertuberkulose.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the Centers for Disease Control. Unexplained CD4+ T-lymphocyte depletion, persons without evident HIV infection
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Perioral Dermatitis
Authors: A. J. Rook, D. S. Wilkinson
Journal: BMJ (1970)

Plasma 11-OHCS and Questionary Results (Means + S. D.) This small study suggests that poor short- term response to antidepressants is related to hypothalamic dysfunction.This lack of response and the presence of hypothalamic dysfunction could not have been predicted from clinical or questionary data.Further studies of specific treatment responses and tests of hypothalamic function are needed in depressed patients.If these findings are replicated, they may be of clinical value in deciding on appropriate treatment for the particular patient and may help in eluci- dating the action of antidepressants.-Weare, etc.,