tbuckley/cabot-search huggingface dataset:
LONG-TERM FOLLOW-UP OF ELDERLY PATIENTS WITH PANCREATIC CYSTS: DESCRIBING THE NATURAL HISTORY AND PREDICTORS OF GROWTH, HIGH-RISK TRANSFORMATION, MALIGNANT TRANSFORMATION AND SURGICAL INTERVENTION
Authors: M. Alkhayyat, M. AbouSaleh, A. Habash, A. Al-Momani, W. Kim, F. Qayyum, C. Martin, R. Simons-Linares, P. Chahal
Journal: Endoscopy (2022)

Aims The utility of imaging surveillance of pancreatic cysts (PC) in advanced age is unclear with no identified optimal age cutoff to discontinue surveillance. We aim to describe the natural history of PC in patients older than 60 and evaluate long-term outcomes.
ENDOSCOPIC ULTRASOUND GUIDED BILIARY DRAINAGE IN MALIGNANT HILAR OBSTRUCTION- EXPERIENCE FROM TERTIARY CARE ONCOLOGY CENTER IN INDIA
Authors: S. Sundaram, K. Mane, A.K. Jain, U. Tyagi, U. Chhanchure, V. Seth, P. Patil, S. Mehta
Journal: Endoscopy (2022)

Aims Endoscopic Ultrasound guided biliary drainage (EUS-BD) is an alternative in patients with distal biliary obstruction and failed ERCP. Data on EUS-BD in hilar obstruction is sparse. We retrospectively analysed outcomes of EUS-BD in malignant hilar obstruction.
43P Dynamic alterations of immunosenescence-related genes in older women with breast cancer receiving chemotherapy
Authors: Q. Wu, B. Brouwers, B.S. Dalmasso, C. Kenis, L. Dal Lago, P. Neven, P. Vuylsteke, G. Debrock, H.F.M. van den Bulck, A. Smeets, A. Laenen, H. Wildiers, S. Hatse
Journal: Annals of Oncology (2022)
Temporal changes in incidence of relapse and outcome after relapse of childhood acute lymphoblastic leukemia over three decades; a Nordic population-based cohort study
Authors: Karen Schow Jensen, Trausti Oskarsson, Päivi M. Lähteenmäki, Trond Flaegstad, Ólafur Gísli Jónsson, Petter Svenberg, Kjeld Schmiegelow, Mats Heyman, Ulrika Norén-Nyström, Henrik Schrøder, Birgitte Klug Albertsen
Journal: Leukemia (2022)
Improved survival of left ventricular assist device carriers in <scp>Europe</scp> according to implantation eras: results from the <scp>PCHF‐VAD</scp> registry
Authors: Nina Jakus, Jasper J. Brugts, Brian Claggett, Philippe Timmermans, Anne‐Catherine Pouleur, Pawel Rubiś, Emeline M. Van Craenenbroeck, Edvinas Gaizauskas, Eduardo Barge‐Caballero, Stefania Paolillo, Sebastian Grundmann, Domenico D'Amario, Oscar Ö. Braun, Aggeliki Gkouziouta, Bart Meyns, Walter Droogne, Karol Wierzbicki, Katarzyna Holcman, Ivo Planinc, Bosko Skoric, Andreas J. Flammer, Hrvoje Gasparovic, Bojan Biocina, Lars H. Lund, Davor Milicic, Frank Ruschitzka, Maja Cikes
Journal: European Journal of Heart Failure (2022)
USE OF METAL STENT FOR BILIARY DRAINAGE PREDICTS SURVIVAL IN A POPULATION OF PATIENTS WITH MALIGNANT BILIARY STRICTURE
Authors: J. Ferreira-Silva, R. Medas, E. Rodrigues-Pinto, P. Pereira, G. Macedo
Journal: Endoscopy (2022)

Aims Optimal strategy for palliative biliary drainage in malignant hilar biliary strictures (MHS) remains controversial. This study evaluated the use of self-expandable metallic stents (SEMS) and plastic stents (PS) in patients with MHS using.
EUS GUIDED GLUE+LIPIODOL INJECTION IN PSEUDOANEURYSM OF PANCREATODUODENAL ARTERY: WHAT WENT WRONG!
Authors: P.N. Desai, R. Prajapati, C. Patel, M. Kabrawala, N. Patel, M. Sethia, R. Mehta, S. Nandwani
Journal: Endoscopy (2022)

46 year male with haematemesis and malena. CECT abdomen- acute on chronic pancreatitis, 12 by 13 mm pseudoaneurysm in wall of proximal second part of duodenum from superior pancreatico duodenal artery. Pseudoaneurysm came in good injecting position only in left lateral position. 1.5ml cyanoacrylate glue with 3 ml lipiodol injected using 19 G needle. 2.3ml confirmed arrest of blood flow. In supine position the glue extravasated in common hepatic artery (CHA) and right gastroepiploic artery. Post severe lactic acidosis developed. Managed conservatively. After a week developed gall bladder necrosis. Cholecystetomy done. Conclusion- Always do EUS vascular intervention in supine position.
Carbohydrate Tolerance Threshold for Unannounced Snacks in Children and Adolescents With Type 1 Diabetes Using an Advanced Hybrid Closed-Loop System
Authors: Gianluca Tornese, Claudia Carletti, Manuela Giangreco, Daniela Nisticò, Elena Faleschini, Egidio Barbi
Journal: Diabetes Care (2022)

OBJECTIVE To find a carbohydrate (CHO) tolerance threshold for unannounced snacks to avoid the 2 h increase in glycemia (difference between pre- and postmeal blood glucose [ΔBG]) ≥50 mg/dL in advanced hybrid closed-loop (a-HCL) users. RESEARCH DESIGN AND METHODS Fourteen children and adolescents with type 1 diabetes (7 females; mean age [± SD] 14.5 ± 3.6 years), users of the Medtronic MiniMed 780G, participated in the study. For 12 days, they did not perform insulin bolus before breakfasts, with defined different quantities and types of CHO, with or without fats, performing blood glucose (BG) before and 2 h after the meal. RESULTS A cutoff of 19.8 g of total CHO was found to determine a ΔBG of 50 mg/dL. BG never exceeded 250 mg/dL. Mean time in range was ≥70% in the 2 h following each snack. CONCLUSIONS Unannounced snacks of up to 20 g of CHO can avoid ΔBG ≥50 mg/dL in MiniMed 780G users, although unannounced meals of up to 30 g of CHO are safe.
First-Line Catheter Ablation of Monomorphic Ventricular Tachycardia in Cardiomyopathy Concurrent With Defibrillator Implantation: The PAUSE-SCD Randomized Trial
Authors: Roderick Tung, Yumei Xue, Minglong Chen, Chenyang Jiang, Dalise Y. Shatz, Stephanie A. Besser, Hongde Hu, Fa-Po Chung, Shiro Nakahara, Young-Hoon Kim, Kazuhiro Satomi, Lishui Shen, Er’peng Liang, Hongtao Liao, Kai Gu, Ruhong Jiang, Jian Jiang, Yuichi Hori, Jong-Il Choi, Akiko Ueda, Yuki Komatsu, Shuichiro Kazawa, Kyoko Soejima, Shih-Ann Chen, Akihiko Nogami, Yan Yao
Journal: Circulation (2022)

Background: Catheter ablation as first-line therapy for ventricular tachycardia (VT) at the time of implantable cardioverter defibrillator (ICD) implantation has not been adopted into clinical guidelines. Also, there is an unmet clinical need to prospectively examine the role of VT ablation in patients with nonischemic cardiomyopathy, an increasingly prevalent population that is referred for advanced therapies globally. Methods: We conducted an international, multicenter, randomized controlled trial enrolling 180 patients with cardiomyopathy and monomorphic VT with an indication for ICD implantation to assess the role of early, first-line ablation therapy. A total of 121 patients were randomly assigned (1:1) to ablation plus an ICD versus conventional medical therapy plus an ICD. Patients who refused ICD (n=47) were followed in a prospective registry after stand-alone ablation treatment. The primary outcome was a composite end point of VT recurrence, cardiovascular hospitalization, or death. Results: Randomly assigned patients had a mean age of 55 years (interquartile range, 46–64) and left ventricular ejection fraction of 40% (interquartile range, 30%–49%); 81% were male. The underlying heart disease was ischemic cardiomyopathy in 35%, nonischemic cardiomyopathy in 30%, and arrhythmogenic cardiomyopathy in 35%. Ablation was performed a median of 2 days before ICD implantation (interquartile range, 5 days before to 14 days after). At 31 months, the primary outcome occurred in 49.3% of the ablation group and 65.5% in the control group (hazard ratio, 0.58 [95% CI, 0.35–0.96]; P =0.04). The observed difference was driven by a reduction in VT recurrence in the ablation arm (hazard ratio, 0.51 [95%CI, 0.29–0.90]; P =0.02). A statistically significant reduction in both ICD shocks (10.0% versus 24.6%; P =0.03) and antitachycardia pacing (16.2% versus 32.8%; P =0.04) was observed in patients who underwent ablation compared with control. No differences in cardiovascular hospitalization (32.0% versus. 33.7%; hazard ratio, 0.82 [95% CI, 0.43–1.56]; P =0.55) or mortality (8.9% versus 8.8%; hazard ratio, 1.40 [95% CI, 0.38–5.22]; P =0.62]) were observed. Ablation-related complications occurred in 8.3% of patients. Conclusions: Among patients with cardiomyopathy of varied causes, early catheter ablation performed at the time of ICD implantation significantly reduced the composite primary outcome of VT recurrence, cardiovascular hospitalization, or death. These findings were driven by a reduction in ICD therapies. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT02848781.
LBA1 Unraveling the mechanism of action and resistance to trastuzumab deruxtecan (T-DXd): Biomarker analyses from patients from DAISY trial
Authors: M.F. Mosele, A. Lusque, V. Dieras, E. Deluche, A. Ducoulombier, B. Pistilli, T. Bachelot, F. Viret, C. Levy, N. Signolle, D. Tran, I.J. Garberis, L. Le-Bescond, A. Tran Dien, N. Droin, M. Kobayashi, T. Kakegawa, M. Jimenez, M. Lacroix-Triki, F. André
Journal: Annals of Oncology (2022)

T-DXd is an anti-HER2 antibody-drug conjugate that has demonstrated high antitumor activity in HER2-positive and HER2-low metastatic breast cancer (mBC). We aimed to unravel the mechanism of action and resistance to T-DXd in patients from DAISY trial. DAISY is a phase II clinical trial (NCT04132960) that assessed T-DXd efficacy in mBC according to HER2-expression (HER2-positive, HER2-low, and HER2-negative). Bystander effect and T-DXd uptake were analyzed by immunohistochemistry (IHC) (HER2, gH2AX, and T-DXd) on tumor biopsies at baseline and on-treatment (n=10 patients). T-DXd immune effects were explored by multiplex immunofluorescence (CD3, CD4, CD8, CD68, FoxP3, PD-1, PD-L1, CK/SOX10 antibodies) on tumor biopsies at baseline and on-treatment (Day 22 or 43, n=31 patients). Mechanisms of resistance were analyzed on tumor samples at baseline (n=118) and at progression by whole exome sequencing (n=24) and IHC (n=25). The predictive value of HER2 spatial distribution was investigated by artificial intelligence (AI) using weakly supervised and clustering algorithms on HER2-positive slides images at baseline (n=61). Molecular analyses showed that cancer cells expressing low levels of HER2, but not HER2-null cells, uptake T-DXd (p=0.053). In the whole population (n=31), a decrease of PDL1-positive cells was associated with a best objective response (BOR) (p=0.008). No modulation of T cells and macrophages was observed (p=0.6 and p=0.9 respectively). A decrease of PDL1 expression was detected in HER2-positive mBC (n=18; p=0.02). Clustering algorithms identified a cluster associated with a lower BOR (p=0.007), whose features identified by AI included a high percentage of HER2-negative cells currently under investigation. At progression, a decrease of HER2 expression was observed in 13/25 (52%) patients (p=0.07). DNA sequencing and final AI results will be available at the meeting. A correlation between HER2 expression and T-DXd uptake in cancer cells was observed in on-treatment biopsies. T-DXd did not modulate intratumoral lymphocytes but decreased PDL1 expression. WES analyses at baseline and progression samples will be presented on-site.
PORTAL HYPERTENSIVE GASTROPATHY IN CHRONIC LIVER DISEASE: PREVALENCE AND ASSOCIATED FEATURES
Authors: A. Hassine, S. Mrabet, R. Tababi, R. Harbi, I. Akkari, A. Hassine, E. Ben Jazia
Journal: Endoscopy (2022)

Aims In terms of Portal hypertension, attention is being mostly focused on searching and treating esophageal and gastric varices. Portal hypertensive gastropathy (PHG) is usually underappreciated. However, it can cause gastrointestinal bleeding. The aim of our study is to determine the prevalence of PHG and to study the clinical and endoscopic features of patients diagnosed with PHG.
COMPARATIVE STUDY ON THE SAFETY OF NON-ANESTHESIOLOGIST ADMINISTERED PROPOFOL SEDATION IN COLORECTAL CANCER SCREENING COLONOSCOPY
Authors: L. De Castro, A. Martínez-Turnes, L. Cid, N. Fernández, B. Romero, A. Rodríguez D’Jesús, A. Germade, V. Hernández, I. Rodríguez-Prada
Journal: Endoscopy (2022)

Aims Non-anesthesiologist administered Propofol (NAAP) sedation in endoscopy has dramatically increased. However, NAAP safety must be assessed for each endoscopic procedure, as their characteristics are not comparable. We aimed to assess the safety of NAAP sedation in screening colonoscopy, a high-quality procedure, of higher complexity than standard colonoscopy.
TANDEM ENDOSCOPE ASSISTED EUS-GUIDED ANTEGRADE STENTING OF BILIARY AND PANCREATIC DUCT IN A SURGICALLY TRANSECTED PAPILLA
Authors: K.D.-C. Pham, R.F. Havre
Journal: Endoscopy (2022)

Iatrogenic injuries to the major papilla involving the pancreatic (PD) and common bile duct (CBD) are challenging to treat. Surgical reconstruction is usually required. We describe the endoscopic reconstruction of the pancreatic and biliary orifices after a surgical complication in a 61-year-old male who underwent duodenal surgery where the papilla was accidentally stapled and resected, and resulted in occlusion of the PD anaCBD. The CBD and PD were accessed from the stomach for antegrade stenting to form pancreaticoduodenectomy and choledochoduodenostomy. The tandem endoscope rendez-vous technique was used due to multiple instrumentation bends, to allow better antegrade pushability.
ENDOSCOPIST ESTIMATE OF POLYP SIZE IS DOUBLE THE ACTUAL SIZE OF NEOPLASIA WITHIN A POLYP
Authors: R. Heda, F. Ghamsari, J. Anderson, S. Hirschman, H. Pohl
Journal: Endoscopy (2022)

Aims Polyp size is a major determinant for post-colonoscopy surveillance. It is unknown how endoscopist size estimates (ES) compares to actual neoplasia size (NS) within a resected polyp. We aimed to compare ES with NS.
Searching clinical trials registers: guide for systematic reviewers
Authors: Kylie E Hunter, Angela C Webster, Matthew J Page, Melina Willson, Steve McDonald, Slavica Berber, Peta Skeers, Ava G Tan-Koay, Anne Parkhill, Anna Lene Seidler
Journal: BMJ (2022)

Systematic reviews should incorporate as much relevant evidence as possible to reduce bias and research waste and increase reliability of results. Clinical trials registers are a key resource for identifying potentially eligible studies, particularly those that are unpublished, and therefore searching these registers is mandated for best practice systematic reviews. However, the process of searching can be challenging and no clear and consistent guidance on how best to do this exists. This paper provides step-by-step guidance on how to conduct systematic searches for studies using clinical trials registers, with a case study to illustrate each step. The guidance encompasses where to search and how to formulate the search strategy, conduct the search, download results, screen records, obtain data, update searches, and report on these searches.
Patient reported outcome assessment must be inclusive and equitable
Authors: Melanie J. Calvert, Samantha Cruz Rivera, Ameeta Retzer, Sarah E. Hughes, Lisa Campbell, Barbara Molony-Oates, Olalekan Lee Aiyegbusi, Angela M. Stover, Roger Wilson, Christel McMullan, Nicola E. Anderson, Grace M. Turner, Elin Haf Davies, Rav Verdi, Galina Velikova, Paul Kamudoni, Syed Muslim, Adrian Gheorghe, Daniel O’Connor, Xiaoxuan Liu, Albert W. Wu, Alastair K. Denniston
Journal: Nature Medicine (2022)
169P Overall survival with first-line palbociclib plus an aromatase inhibitor (AI) vs AI in metastatic breast cancer: A large real-world database analysis
Authors: H.S. Rugo, A. Brufsky, X. Liu, B. Li, L. McRoy, C. Chen, R.M. Layman, M. Cristofanilli, M.A. Torres, G. Curigliano, R.S. Finn, A. Demichele
Journal: Annals of Oncology (2022)
100P Outcomes of non-metastatic triple negative breast cancers: Real-world data from a large Indian cohort
Authors: J. Bajpai, L. Kashyap, D.H. Vallathol, R. Pathak, S. Rath, A. Sekar, S. Mohanta, A. Reddy, S. Joshi, T. Wadasadawala, N. Nair, V. Parmar, S. Desai, T. Shet, M. Thakur, R. Sarin, S. Gupta, R. Badwe, A. Das, M. Singh
Journal: Annals of Oncology (2022)
APPLICATION OF MACHINE LEARNING ALGORITHM BASED ON MULTI-FEATURE FITTING IN THE DIAGNOSIS OF WHITISH NEOPLASTIC GASTRIC LESIONS UNDER WHITE LIGHT GASTROSCOPY
Authors: X. Zeng, Z. Dong, D. Gong, P. Jin, L. Yang, H. Yu
Journal: Endoscopy (2022)

Aims To develop machine-learning based multi-feature fitting algorithm to diagnose whitish neoplastic gastric lesions under white light endoscopy and enhance interpretability. Compare the diagnostic performance of the algorithms with the sole deep learning algorithm.
THE NEEDLE-INCISION-SNARE TECHNIQUE USING A SINGLE INECTION-SNARE DEVICE FOR KNIFE-ASSISTED RESECTION (EMR-ESD HYBRID ENDOSCOPIC RESECTION)
Authors: K. Mönkemüller, F. Hornung, A. Hamm, J. Fiedler, A. Naewie, A. Martínez-Alcalá
Journal: Endoscopy (2022)

Advanced endoscopic resection encompasses the utilization of injection needle to create the submucosal cushion followed by incision using a needle, and dissection using a knife. We have developed a technique using a single device for accomplishing hybrid EMR-ESD. This approach using a single device to perform advanced resection is practical as it saves time, as injection is immediately available, followed by incision and dissection using the snare's metal tip, for final in toto excision of the specimen with the snare. This device and technique have the potential of improving the acceptance and performance of ESD or ESD-EMR hybrid procedures worldwide.
COMPARATIVE EFFICACY AND SAFETY OUTCOMES OF ENDOSCOPIC ULTRASOUND-GUIDED LUMEN-APPOSING METAL STENTS DRAINAGE FOR PANCREATIC PSEUDOCYSTS AND WALLED-OFF NECROSIS – A SINGLE-CENTER EXPERIENCE
Authors: K. Gröhl, A. Ebigbo, E. Schnoy, G. Braun, T. Weber, S.K. Goelder, H. Messmann, S. Nagl
Journal: Endoscopy (2022)

Aims Endoscopic ultrasound (EUS)-guided transmural drainage is considered the first-line treatment of pancreatic fluid collections (PFCs). The results of LAMS drainage for different PFC types remain controversial. This study aimed to compare the outcome and safety of LAMS drainage for walled-off necrosis (WON) and pancreatic pseudocysts (PPC).
Addition of four doses of rituximab to standard induction chemotherapy in adult patients with precursor B-cell acute lymphoblastic leukaemia (UKALL14): a phase 3, multicentre, randomised controlled trial
Authors: David I Marks, Amy A Kirkwood, Clare J Rowntree, Melanie Aguiar, Katharine E Bailey, Brendan Beaton, Paul Cahalin, Anna Z Castleton, Laura Clifton-Hadley, Mhairi Copland, Anthony H Goldstone, Richard Kelly, Emma Lawrie, SooWah Lee, Andrew K McMillan, Mary Frances McMullin, Tobias F Menne, Rachel J Mitchell, Anthony V Moorman, Bela Patel, Pip Patrick, Paul Smith, David Taussig, Deborah Yallop, Krisztina Zuborne Alapi, Adele K Fielding
Journal: The Lancet Haematology (2022)
PREDICTORS OF PROXIMAL MIGRATION OF BILIARY PLASTIC STENTS : EXPERIENCE FROM HIGH VOLUME TERTIARY CARE CENTRE IN INDIA
Authors: A. Kale, M. Aggarwal, S. Sundaram, S. Giri, N. Patwardhan, L. Garg, M. Kuruthukulangara, M. Satai, A. Shukla
Journal: Endoscopy (2022)

Aims Proximal migration of biliary plastic stents (PS) remains a challenging condition to manage with need for additional manipulation in the biliary tree. Our aim was to assess predictors of internally migrated biliary plastic stents.
THE ROLE OF THE CHOLANGIOSCOPY- GUIDED BIOPSY IN THE DIAGNOSIS OF INDETERMINATE BILIARY STRICTURES
Authors: P. Karagyozov, I. Zhecheva, I. Tishkov, K. Draganov
Journal: Endoscopy (2022)

Aims The aim is to asses the role of cholangioscopy- guided biopsy in the diagnosis of indeterminate biliary strictures.
Bronchotracheal Compression Caused by Esophageal Impaction after Bilateral Lung Transplantation
Authors: Aleksandra C. Zoethout, Michiel E. Erasmus, Erik Verschuuren, Janesh Pillay
Journal: American Journal of Respiratory and Critical Care Medicine (2021)

"Bronchotracheal Compression Caused by Esophageal Impaction after Bilateral Lung Transplantation." American Journal of Respiratory and Critical Care Medicine, 205(7), pp. 842–843
A VERY RARE CAUSE OF DIGESTIVE HEMORRHAGE
Authors: Â. Domingues, R. Araújo, F. Pires, A.C. Carvalho, S. Ventura, C. Rodrigues, J. Pinho, D. Martins, P. Sousa, R. Cardoso, E. Cancela, A. Castanheira, P. Ministro, A. Silva
Journal: Endoscopy (2022)

Results This is a case study of an 82-year-old woman with a history of hypocoagulated atrial fibrillation, microcytic anemia and excised left genial malignant lentigo in 2018. She was admitted to the emergency department due to asthenia and decreased strength of the inferior limbs with two days of evolution. No visible blood loss was evident. She presented a history of darkened feces although she was under oral iron therapy. In the objective examination she had pale mucous membranes and a systolic murmur. Abdominal and neurologic examination were normal. Blood analysis: hemoglobin 6.5g/dL, INR 13.08 and urea 132mg/dL. She underwent erythrocyte concentrate transfusion and reverted the iatrogenic hypocoagulation. Abdominal ultrasound revealed thickening of the gastric antrum and multiple adenopathies nearby the head of the pancreas. Upper digestive endoscopy revealed several circular and friable, black papular lesions in the body and fundus gastric and duodenal bulb, with depressed center and with stigmas of recent hemorrhage.
220P Distant disease-free survival according to different subtypes in young breast cancer patients (YBCP)
Authors: B. Cantos, M. Mendez Garcia, J.C. Sanchez Gonzalez, B. Nuñez Garcia, M. Blanco Clemente, C. Traseira Puchol, R. Aguado, A. Royuela, S.C. Gonzalez Gonzalez, M. Provencio Pulla
Journal: Annals of Oncology (2022)
CANNULATION BY DIRECT VISION OF THE BILE DUCT WITH A CHOLANGIOSCOPE IN A PATIENT WHO RECEIVED A LIVER TRANSPLANT WITH ANASTOMOTIC STENOSIS AND BILE LEAKAGE
Authors: S.Blanco Rey, I. El Hajra Martínez, M. González-Haba Ruiz
Journal: Endoscopy (2022)

We present the case of a 57-year-old man who received a liver transplantation. ERCP with sphincterotomy was performed 5 months later, observing a late short stenosis immediately distal to the cystic duct insertion in the common bile duct and contrast extravasation at this level after performing pressure cholangiography. Due to the impossibility of progression of the 0.035'' and 0.025'' guidewires, a cholangioscope was introduced to cannulate by direct vision. After several attempts the guidewire of 0.025 '' is progressed, facilitating the placement of a covered metal biliary stent of 8mm x 8cm. The patient could be discharged 48 hours later.