tbuckley/cabot-search huggingface dataset:
Minerva
Authors: M Hashir Ariff
Journal: BMJ (2007)

Another paper that analyses the quality of scientific research says that even use of the randomised controlled trial-the supposed optimal design of trials-doesn't ensure high quality research or reporting (Journal of Bone and Joint Surgery Am 2007;89:1693-9).In their review of 54 randomised trials of treatment for tennis elbow, the two reviewers found many areas of deficiency, including poor descriptions of recruitment, poor power calculations, and poor randomisation and blinding as well as inadequate follow-up.Scientists, they say, must adhere to the CONSORT (Consolidated Standards of Reporting Trials) criteria.
TCT CONNECT-390 Safety and Efficacy of Sirolimus-Eluting Stent System in All-Comers Real-World Population With Coronary Artery Stenosis: The MILES-Global Study
Authors: Martin Hudec, A.J.J. IJsselmuiden, Ramiro Trillo, Hyeon-Cheol Gwon, Myung Ho Jeong, Yi-chih Wang, José Marques da Costa, In-Ho Chae, Min-Ji Charng, Oteh Maskon, Jose Moreu Burgos, G. Mayurathan, Hristo Mateev, Antonio Serra, Bela Merkely, Rita Theotonio, Chun Yao Huang, Samih Lawand, Philip Mar, Andriy Khokhlov, Beatriz Montilla, Mariano Valdes Chavarri, None Mohammad Sadeghian
Journal: Journal of the American College of Cardiology (2020)
P1.08-003 Concomitant Chemotherapy and Radiotherapy with SBRT Boost for Unresectable, Stage III Non-Small Cell Lung Cancer: A Phase I Study
Authors: K. Higgins, R. Pillai, Z. Chen, C. Zhang, P. Patel, S. Pakkala, J. Shelton, S. Force, F. Fernandez, C. Steuer, T. Owonikoko, S. Ramalingam, J. Bradley, W. Curran
Journal: Journal of Thoracic Oncology (2017)
Influence of Light Intensity exercise During Pregnancy on Fetal Echocardiographic and Maternal Cardiovascular Measures
Authors: Linda E May, Brooke N Davis, Carol A Johnston, Lauren Sarno, Dennis Steed, Diana Strickland, Samantha M McDonald, Breanne L. Wisseman, Ed Newton, Christy Isler, Seonae Yeo, Devon Kuehn
Journal: Clinical Cardiology and Cardiovascular Interventions (2022)

Background: Although moderate intensity maternal exercise is recommended during pregnancy, most women do not achieve this level. Objective: This study aimed to determine the effects of supervised maternal light-intensity exercise on fetal cardiovascular measures in the 3rd trimester. Materials and Methods: We compared women participating in light-intensity (LI) stretching/breathing or no exercise (CON) across 24+ weeks of pregnancy Women with singleton pregnancies (&lt;16 weeks), between 18-40 years, 18.5-34.99 kg/m2 BMI, and having no chronic health conditions were eligible. LI did 150 minutes light-intensity weekly exercise; CON did normal daily activities, but no exercise. Maternal measures included resting heart rate (HR) and blood pressure (BP). Fetal measures included estimated fetal weight (EFW), ponderal index (PI), HR, along with right and left ventricular measures (e.g., stroke volume, cardiac output, ejection fraction) at 36 weeks’ gestation. T-tests compared differences between groups; partial spearman rank correlations and regressions were performed to find relationships and predict fetal echocardiographic outcomes, controlling for fetal activity state. Results: Of 50 pregnant women (n=26 in LI, n=24 in CON), we found maternal exercise intensity influences fetal left ventricular heart flow, while maternal exercise duration influences fetal right ventricular outcomes. There were no differences (p&gt;0.05) in fetal cardiac anatomical measures. Lastly, light intensity exercise and duration of exercise lower maternal blood pressure in late pregnancy. Conclusions:Light-intensity exercise is associated with improved fetal cardiac measures. Women benefit from light intensity exercise during pregnancy. Cardiovascular benefits from exercise for mother and child are dose dependent.
Arboviral Infections of the Central Nervous System—United States, 1987
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of Immunogenicity of an Inactivated SARS-CoV-2 Vaccine Prototype in vitro
Authors: Andrei Hancharou, N. Antonevich, T. Pozniak, Darya Babrukevich, P. Semizhon, E. Scheslenok, A. Rynda, O. Timohina, Y. Minich, Lawrence DuBuske
Journal: Journal of Allergy and Clinical Immunology (2022)
The Minimally Invasive 1-Hr Esophageal String Test (EST) Monitors Changes in Mucosal Inflammation in Pediatric and Adult Eosinophilic Esophagitis Patients During Treatment
Authors: Steven Ackerman, Amir Kagalwalla, Joshua Wechsler, Kaitlin Keeley, Nirmala Gonsalves, Ikuo Hirano, Angelika Zalewski, Paul Paul Menard-Katcher, Nikhil Chauhan, Milica Grozdanovic, Glenn Furuta
Journal: Journal of Allergy and Clinical Immunology (2022)
Chronic myeloid leukemia with minor‐bcr breakpoint developed hybrid type of blast crisis
Authors: Tatsuharu Ohno, Shigefusa Hada, Tateo Sugiyama, Takashi Mizumoto, Hiroo Furukawa, Ken‐ichi Nagai
Journal: American Journal of Hematology (1998)

Although a breakpoint in the minor breakpoint cluster region (m-bcr) of the BCR gene is observed in about two-thirds of patients with Philadelphia chromosome-positive acute lymphoblastic leukemia, this type of genomic rearrangement occurs very rarely in chronic myeloid leukemia (CML). We describe here the eighth case of m-bcr CML, and delineate unique clinical characteristics found in common to the 7 cases reported previously. Monocytosis with a low neutrophil/monocyte ratio resembling chronic myelomonocytic leukemia was the most striking feature of m-bcr CML. Splenomegaly and basophilia were not conspicuous in chronic phase. A high percentage of immature granulocytes and low neutrophil alkaline phosphatase score were the findings in common with classical CML. Lymphoid and myeloid blast changes have been observed at and shortly after presentation so far. We found a hybrid type of blast crisis in the course of m-bcr CML.Thus, m-bcr CML may be a definite subtype of CML, exhibiting distinct clinical characteristics. The presence of fusion product of m-bcr mRNA in an earlier myeloid cell may involve monocytic lineage in addition to myeloproliferative defects. Am. J. Hematol. 57:320–325, 1998. © 1998 Wiley-Liss, Inc.
Hennekens Reconsidered
Authors: H. B. HOUSER
Journal: JNCI Journal of the National Cancer Institute (1988)

Hennekens Reconsidered Get access HAROLD B. HOUSER HAROLD B. HOUSER Department of Epidemiology and Biostatistics School of Medicine case Western Reserve UniversityCleveland, OH 44106 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 8, 15 June 1988, Pages 604–605, https://doi.org/10.1093/jnci/80.8.604-b Published: 15 June 1988
Anti–SARS-CoV-2 Monoclonal Antibody Distribution to High-risk Medicare Beneficiaries, 2020-2021
Authors: Caroline L. Behr, Karen E. Joynt Maddox, Ellen Meara, Arnold M. Epstein, E. John Orav, Michael L. Barnett
Journal: JAMA (2022)

This study assesses how a limited supply of monoclonal antibody therapy was allocated to patients at highest risk of severe disease among a population of fee-for-service Medicare beneficiaries with a new COVID-19 diagnosis or confirmed exposure between November 2020 and August 2021.
Manuscripts Approved for JNCI, April-May 1972
Journal: JNCI Journal of the National Cancer Institute (1972)

Manuscripts Approved for JNCI, April-May 1972 Get access JNCI: Journal of the National Cancer Institute, Volume 48, Issue 6, June 1972, Pages 1920–1922, https://doi.org/10.1093/jnci/48.6.1920 Published: 01 June 1972
Anterior marginal articular fracture of distal radius
Authors: O. E. Aufranc
Journal: JAMA (1966)

Dr. John Larkin: A 38-year-old white male laborer was involved in an automobile collision and was thrust against the instrument panel of his vehicle. The back of his wrist struck the panel and the patient reports that his wrist was palmar flexed forcibly at the time of his injury. He sustained a contusion of the scalp and a fractured wrist. Examination in the emergency ward at the Massachusetts General Hospital showed no evidence of brain damage or significant systemic injury. X-ray films showed a volar marginal fracture of the distal articular surface of the radius with anterior subluxation of the distal fragment and of the carpal bones (Fig 1). An axillary block was performed and reduction of the fracture was attempted. The wrist was positioned in 25° of wrist dorsiflexion and neutral forearm rotation, as is recommended in most standard fracture textbooks. Follow-up x-ray films showed persistent anterior subluxation of
<i>Erratum:</i> Vol. 70, No. 51–52
Authors: Valentine Wanga, Megan Gerdes, Dallas Shi, Rewa Choudhary, Theresa Dulski, Sophia Hsu, Osatohamwen Idubor, Bryant Webber, Arthur Wendel, Nickolas Agathis, Kristi Anderson, Tricia Boyles, Sophia Chiu, Eleanor Click, Juliana Da Silva, Hannah Dupont, Mary Evans, Jeremy Gold, Julia Haston, Pamela Logan, Susan Maloney, Marisol Martinez, Pavithra Natarajan, Kevin Spicer, Mark Swancutt, Valerie Stevens, Jessica Brown, Gyan Chandra, Megan Light, Frederick Barr, Jessica Snowden, Larry Kociolek, Matthew Mchugh, David Wessel, Joelle Simpson, Kathleen Gorman, Kristen Breslin, Roberta Debiasi, Aaron Thompson, Mark Kline, Julie Boom, Ila Singh, Michael Dowlin, Mark Wietecha, Beth Schweitzer, ; Sapna, Bamrah Morris, Emily Koumans, Jean Ko, Anne Kimball, David Siegel
Journal: MMWR Morbidity and Mortality Weekly Report (2022)
Translational Regulation of Cancer Metastasis
Authors: Douglas S. Micalizzi, Richard Y. Ebright, Daniel A. Haber, Shyamala Maheswaran
Journal: Cancer Research (2021)

Deregulation of the mRNA translational process has been observed during tumorigenesis. However, recent findings have shown that deregulation of translation also contributes specifically to cancer cell spread. During metastasis, cancer cells undergo changes in cellular state, permitting the acquisition of features necessary for cell survival, dissemination, and outgrowth. In addition, metastatic cells respond to external cues, allowing for their persistence under significant cellular and microenvironmental stresses. Recent work has revealed the importance of mRNA translation to these dynamic changes, including regulation of cell states through epithelial-to-mesenchymal transition and tumor dormancy and as a response to external stresses such as hypoxia and immune surveillance. In this review, we focus on examples of altered translation underlying these phenotypic changes and responses to external cues and explore how they contribute to metastatic progression. We also highlight the therapeutic opportunities presented by aberrant mRNA translation, suggesting novel ways to target metastatic tumor cells.
Post-Marketing Survey Evaluating the Safety and Efficacy of the SQ House Dust Mite (HDM) Sublingual Immunotherapy-Tablet in Japanese Patients with HDM-Induced Allergic Rhinitis (Stratified analysis by &lt;18 years and &gt; 18 years, 2016-2020)
Authors: Yuriko Maekawa, Hiroki Matsuhara, Satoko Kobayashi
Journal: Journal of Allergy and Clinical Immunology (2022)
The Amateur Sportsman
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ASSOCIATION NEWS.
Journal: JAMA (1898)

<h3>The Senn Medal.</h3> —Those members of theAmerican Medical Associationintending to compete for the medal offered by Dr. Senn for the best essay on some surgical subject, are requested to forward the type-written copies of contributions before March 1, 1898. Address, J.McFadden Gaston, M.D., Chairman, Atlanta, Ga.
Philadelphia Clerkship in Occupational Safety and Health
Journal: JNCI Journal of the National Cancer Institute (1979)

Philadelphia Clerkship in Occupational Safety and Health Get access JNCI: Journal of the National Cancer Institute, Volume 62, Issue 3, March 1979, Page 712, https://doi.org/10.1093/jnci/62.3.712-a Published: 01 March 1979
THE PROBLEM OF RHEUMATISM AND ARTHRITIS: REVIEW OF AMERICAN AND ENGLISH LITERATURE FOR 1938: (Sixth Rheumatism Review)
Authors: PHILIP S.  HENCH, WALTER  BAUER, M. HENRY  DAWSON, FRANCIS  HALL, W. PAUL  HOLBROOK, J. ALBERT  KEY, CURRIER  MCEWEN
Journal: Annals of Internal Medicine (1940)

Article1 March 1940THE PROBLEM OF RHEUMATISM AND ARTHRITIS(Sixth Rheumatism Review)*PHILIP S. HENCH, M.D., F.A.C.P., WALTER BAUER, M.D., F.A.C.P., M. HENRY DAWSON, M.D., FRANCIS HALL, M.D., F.A.C.P., W. PAUL HOLBROOK, M.D., F.A.C.P., J. ALBERT KEY, M.D., CURRIER MCEWEN, M.D., F.A.C.P.PHILIP S. HENCH, M.D., F.A.C.P.Search for more papers by this author, WALTER BAUER, M.D., F.A.C.P.Search for more papers by this author, M. HENRY DAWSON, M.D.Search for more papers by this author, FRANCIS HALL, M.D., F.A.C.P.Search for more papers by this author, W. PAUL HOLBROOK, M.D., F.A.C.P.Search for more papers by this author, J. ALBERT KEY, M.D.Search for more papers by this author, CURRIER MCEWEN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-9-1655 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn Two PartsCONTENTSPart IGeneral incidence of rheumatic diseases 1656Definition of "rheumatism" 1657Classification of diseases of joints and related structures 1657Diseases of joints related primarily to trauma 1659Gonorrheal arthritis, gonorrheal rheumatism 1663Sulfanilamide: general considerations 1673Treatment of gonorrheal arthritis with sulfanilamide 1682Treatment of gonorrhea by newer sulfonamide compounds 1695Tuberculous arthritis 1699Tuberculous rheumatism 1703Pneumococcal arthritis 1703Syphilitic arthritis and synovitis: Charcot (tabetic) joints 1704Brucellosis, undulant (Malta) fever 1706Typhoid arthritis: "typhoid spine" 1711Meningococcic arthritis 1711Suppurative (purulent, septic) arthritis 1713Articular disease due to hemolytic streptococci 1713Arthritis... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *This Sixth Rheumatism Review was prepared by the Editorial Committee (Dr. Hench, Chairman) of the American Rheumatism Association. The editorial comments express the opinion of the Editorial Committee, the authors of the Review, not that of the Association.Received for publication January 9, 1940. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byClinical and serologic observations in patients with juvenile rheumatoid arthritis and their relativesPeriarteriitis nodosaThe relationship to rheumatoid arthritis of its so-called variantsB diethylaminoethly dehydrocholate in the treatment of fibrositis 1 March 1940Volume 13, Issue 9Page: 1655-1739KeywordsAmyotrophic lateral sclerosisArthritisBrucellosisFeversGonorrheaRheumatic feverSpineSulfonamideTyphoid ePublished: 1 December 2008 Issue Published: 1 March 1940 PDF downloadLoading ...
The Role of the Spleen in Resistance to Infection
Authors: J. Bohnsack
Journal: Annual Review of Medicine (1986)

CD40 is a cell-surface member of the TNF (tumor necrosis factor) receptor superfamily. Upon activation, CD40 can license dendritic cells to promote antitumor T cell activation and re-educate macrophages to destroy tumor stroma. Numerous agonist CD40 ...Read More
Queries and Minor Notes
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Practical Urology
Authors: Bernard R. Sears
Journal: JAMA (1969)

It is a pleasure to welcome Dr. Winter's new book. It is a stroke of virtuosity. Unceasing selectivity and refinement enable him to present a dynamic synopsis of classic and scientific urology in a deceptively slim volume. Addressed to all sectors of the profession, it serves equally well for reference or as a textbook and should be especially valued by house officers and students whose formal instruction has been abbreviated by the modified curriculum. The book opens with a chapter on examination and investigation, followed by chapters on each of the seven genitourinary structures and by a discussion of infertility and impotence. Each chapter ends with a quiz, a reading list of classic and current literature, and a list of motion pictures. There are numerous tables, graphs, reproductions of roentgenographic and isotope studies, diagrams, surgical drawings, photographs, and microphotographs. The illustrations and legends bear close inspection because they often continue
Standardizing reporting of brain and central nervous system tumors in the United Kingdom
Authors: Michael T C Poon, Paul M Brennan, Kai Jin, Cathie L M Sudlow, Jonine D Figueroa
Journal: Neuro-Oncology (2022)

Routine reporting of descriptive population-based brain tumor epidemiological data is important for evaluating incidence trends, providing clues for putative risk factors, benchmarking outcomes, and stimulating research into the causes of this deadly disease. We propose to standardize reporting of cancer registry data for brain tumors in the United Kingdom through researcher-led collaborations. Interpretation of incidence trends needs to account for changing diagnostic practice. In the United Kingdom, reports from government agencies do not provide epidemiological data of brain tumor subtypes beyond the overall burden of these tumors. Using the Welsh cancer registry, we have demonstrated that separate reporting of histologically confirmed tumors enhances the interpretation of age- and sex-adjusted brain tumor incidence trends because only patients undergoing surgery would have a histological diagnosis of disease. Wanis et al1 reported on English brain tumor cancer registry data from 1995 to 2017 and observed similar patterns as we described for Wales.2 One exception was that Wanis et al did not report results by histological diagnosis, which we propose should become a standard analysis to document trends accounting for changing diagnostic practice. We have already been in touch with the authors to discuss collaborative analyses to standardize reporting of brain tumor incidence data from Wales, Scotland, and England, with the aim of providing a comprehensive and clinically informed UK-wide picture of brain and CNS tumor incidence trends, similar to the annual publication from the Central Brain Tumor Registry of the United States (CBTRUS).3
Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology: Implications for Alzheimer's disease therapy
Authors: Chuanbin Yang, Chengfu Su, Ashok Iyaswamy, Senthil Kumar Krishnamoorthi, Zhou Zhu, Sichang Yang, Benjamin Chunkit Tong, Jia Liu, Sravan G. Sreenivasmurthy, Xinjie Guan, Yuxuan Kan, Aston Jiaxi Wu, Alexis Shiying Huang, Jieqiong Tan, Kingho Cheung, Juxian Song, Min Li
Journal: Acta Pharmaceutica Sinica B (2022)

Alzheimer's disease (AD), characterized by the accumulation of protein aggregates including phosphorylated Tau aggregates, is the most common neurodegenerative disorder with limited therapeutic agents. Autophagy plays a critical role in the degradation of phosphorylated Tau aggregates, and transcription factor EB (TFEB) is a master regulator of autophagy and lysosomal biogenesis. Thus, small-molecule autophagy enhancers targeting TFEB hold promise for AD therapy. Here, we found that celastrol, an active ingredient isolated from the root extracts of Tripterygium wilfordii (Lei Gong Teng in Chinese) enhanced TFEB-mediated autophagy and lysosomal biogenesis in vitro and in mouse brains. Importantly, celastrol reduced phosphorylated Tau aggregates and attenuated memory dysfunction and cognitive deficits in P301S Tau and 3xTg mice, two commonly used AD animal models. Mechanistical studies suggest that TFEB-mediated autophagy-lysosomal pathway is responsible for phosphorylated Tau degradation in response to celastrol. Overall, our findings indicate that Celastrol is a novel TFEB activator that promotes the degradation of phosphorylated Tau aggregates and improves memory in AD animal models. Therefore, Celastrol shows potential as a novel agent for the treatment and/or prevention of AD and other tauopathies.