tbuckley/cabot-search huggingface dataset:
POS1118 THE RELEVANCE OF OSTEOPOROSIS DIAGNOSIS AND TREATMENT FOR DOCTORS WORKING IN THE FIELD OF PHYSICAL AND REHABILITATION MEDICINE
Authors: L. Marchenkova, V. Vasileva
Journal: Annals of the Rheumatic Diseases (2021)

Background: There is a high prevalence of osteoporosis (OP) among patients of the older age undergoing rehabilitation. Therefore, it is obvious that physicians working in the field of physical and rehabilitative medicine should be well oriented in this medical problem. Objectives: to study the relevance of the problem of osteoporosis (OP) for physicians working in the field of physical and rehabilitation medicine, their awareness of the main methods of diagnosis, treatment and prevention of this disease, as well as the frequency of their use in daily clinical activities. Methods: A cross-type study was carried out using a questionnaire survey. The study included 157 doctors (M-34, F-123) of 8 medical specialties working in 27 specialized medical institutions on the profile of “medical rehabilitation. The questionnaire for doctors consisted of 21 items of special questions. Results: 90.45% of the surveyed doctors believed that the problem of OP is relevant for their clinical activities, 100% of the respondents indicated that the presence of OP significantly affects the rehabilitation prognosis and 95.54% - on the degree of effectiveness of medical rehabilitation. According to the respondents, patients with OP make up on average 30.0% [20.0; 50.0] (0-90) of the total flow of patients. 92.36% (145/157) of doctors indicated that they know the risk factors for OP, 98.73% (155/157) - methods for diagnosing OP, 68.79% (108/157) - methods for treating OP, 80.25 % (126/157) - methods of preventing OP, 47.13% (74/157) - what is FRAX. However, 35.01% (55/157) of the respondents considered their level of awareness of the problem sufficient for managing patients with OP. Diagnostic procedures for OP are recommended by all endocrinologists (100%) and the majority of traumatologists (72.73%), gynecologists (66.67) and cardiologists (64.28%), as well as on average half (50%) neurologists and therapists. Endocrinologists (100%), gynecologists (66.67%) and therapists (60%) are mainly involved in the treatment of OP. 32.48% (51/157) of physicians have ever referred their patients to a bone mineral density assessment. Conclusion: Conclusion. The problem of OP is relevant for the clinical activities of specialists in physical and rehabilitation medicine, and there is the need for advanced training on the problem of OP among these specialists. Disclosure of Interests: None declared.
SIGLEC-3 (CD33) serves as an immune checkpoint receptor for HBV infection
Authors: Tsung-Yu Tsai, Ming-Ting Huang, Pei-Shan Sung, Cheng-Yuan Peng, Mi-Hua Tao, Hwai-I Yang, Wei-Chiao Chang, An-Suei Yang, Chung-Ming Yu, Ya-Ping Lin, Ching-Yu Bau, Chih-Jen Huang, Mei-Hung Pan, Chung-Yi Wu, Chwan-Deng Hsiao, Yi-Hung Yeh, Shiteng Duan, James C Paulson, Shie-Liang Hsieh
Journal: Journal of Clinical Investigation (2021)

Chronic hepatitis B (CHB) infection is rarely eradicated by current antiviral nucleos(t)ide analogues. We found that α2,6-biantennary sialoglycans of HBV surface antigen (HBsAg) bound human SIGLEC-3 (CD33) by IP and ELISA, and the binding affinity between SIGLEC-3 and α2,6-biantennary sialoglycans was determined by biolayer interferometry (equilibrium dissociation constant [KD]: 1.95 × 10–10 ± 0.21 × 10–10 M). Moreover, HBV activated SIGLEC-3 on myeloid cells and induced immunosuppression by stimulating immunoreceptor tyrosine-based inhibitory motif phosphorylation and SHP-1/-2 recruitment via α2,6-biantennary sialoglycans on HBsAg. An antagonistic anti–SIGLEC-3 mAb reversed this effect and enhanced cytokine production in response to TLR-7 agonist GS-9620 in PBMCs from CHB patients. Moreover, anti–SIGLEC-3 mAb alone was able to upregulate the expression of molecules involved in antigen presentation, such as CD80, CD86, CD40, MHC-I, MHC-II, and PD-L1 in CD14+ cells. Furthermore, SIGLEC-3 SNP rs12459419 C, which expressed a higher amount of SIGLEC-3, was associated with increased risk of hepatocellular carcinoma (HCC) in CHB patients (HR: 1.256, 95% CI: 1.027–1.535, P = 0.0266). Thus, blockade of SIGLEC-3 is a promising strategy to reactivate host immunity to HBV and lower the incidence of HCC in the CHB patient population.
COVID-19 vaccination advice via SMS-based video to improve vaccination uncertainty in at-risk groups
Authors: James Bateman, Natasha Cox, Lavanya Rajagopala, Mark Ford, Muhamad Jasim, Diarmuid Mulherin, Srinivasan Venkatachalam, Barbara Douglas, George Hirsch, Tom Sheeran
Journal: The Lancet Rheumatology (2021)
POS0391 ASSESSING SENESCENT HUMAN LYMPH NODE STROMAL CELLS DURING RHEUMATOID ARTHRITIS DEVELOPMENT
Authors: T. de Jong, J. W. Bolt, J. F. Semmelink, L. van Baarsen
Journal: Annals of the Rheumatic Diseases (2021)

Background: Cellular senescence is a state of proliferation arrest of cells. The persistence and accumulation of senescent cells has been implicated in the pathogenesis of age-related diseases like rheumatoid arthritis (RA). Clinical disease is preceded by loss of immune tolerance and autoimmunity. Lymph node stromal cells (LNSC) are important regulators of this tolerance. Therefore, senescent LNSC may affect tolerance and the development of systemic autoimmunity. Objectives: To determine the extent of cellular senescence of LNSC during early phases of systemic autoimmunity. Methods: We included individuals with arthralgia without any evidence of arthritis who were positive for IgM rheumatoid factor (IgM-RF) and/or anti-citrullinated protein antibodies (ACPA; RA-risk group), early arthritis patients (ACR/EULAR 2010 criteria; disease duration &lt; 1 year) and seronegative healthy controls. All study subjects underwent ultrasound-guided inguinal lymph node biopsy. LNSC were isolated and cultured from freshly collected lymph node needle biopsies and passages 0-9 were used for experiments. Cellular senescence was assessed by measuring cell size, granularity, autofluorescence, senescence-associated gene expression levels, DNA damage and senescence-associated β-galactosidase (SA β-gal) activity. Results: Preliminary flow cytometry data shows that the cell size and autofluorescence of LNSC from RA patients (n=11) and RA-risk individuals (n=7) is increased compared with healthy LNSC (n=7), while granularity was specifically increased in LNSC from RA patients (n=9). Initial stainings indicate higher SA β-gal activity and more DNA damage in LNSC from RA-risk (n=3) and RA patients (n=4) compared with healthy controls (n=3). Expression levels of senescence-associated genes such as p21 and p53 were significantly higher in LNSC from RA patients compared with healthy controls (n=6 per group). Conclusion: These preliminary findings suggest senescence already in early RA and provide a rationale for investigating the consequence of senescent LNSC on immune cell responses Disclosure of Interests: None declared
Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in &gt;1.2 million individuals highlight new therapeutic directions
Authors: Daniel F. Levey, Murray B. Stein, Frank R. Wendt, Gita A. Pathak, Hang Zhou, Mihaela Aslan, Rachel Quaden, Kelly M. Harrington, Yaira Z. Nuñez, Cassie Overstreet, Krishnan Radhakrishnan, Gerard Sanacora, Andrew M. McIntosh, Jingchunzi Shi, Suyash S. Shringarpure, John Concato, Renato Polimanti, Joel Gelernter
Journal: Nature Neuroscience (2021)
Ultrasound halo sign as a potential monitoring tool for patients with giant cell arteritis: a prospective analysis
Authors: Cristina Ponte, Sara Monti, Carlo Alberto Scirè, Paolo Delvino, Nikita Khmelinskii, Alessandra Milanesi, Vítor Teixeira, Fabio Brandolino, Fernando Saraiva, Carlomaurizio Montecucco, João Eurico Fonseca, Wolfgang A Schmidt, Raashid Ahmed Luqmani
Journal: Annals of the Rheumatic Diseases (2021)

Objectives To assess the sensitivity to change of ultrasound halo features and their association with disease activity and glucocorticoid (GC) treatment in patients with newly diagnosed giant cell arteritis (GCA). Methods Prospective study of patients with ultrasound-confirmed GCA who underwent serial ultrasound assessments of the temporal artery (TA) and axillary artery (AX) at fixed time points. The number of segments with halo and maximum halo intima–media thickness (IMT) was recorded. Time points in which &gt;80% of patients were assessed were considered for analysis. Halo features at disease presentation and first relapse were compared. Results 49 patients were assessed at 354 visits. Halo sensitivity to change was assessed at weeks 1, 3, 6, 12 and 24 and showed a significant standardised mean difference between all time points and baseline for the TA halo features but only after week 6 for the AX halo features. The number of TA segments with halo and sum and maximum TA halo IMT showed a significant correlation with erythrocyte sedimentation rate (0.41, 0.44 and 0.48), C reactive protein (0.34, 0.39 and 0.41), Birmingham Vasculitis Activity Score (0.29, 0.36 and 0.35) and GC cumulative dose (−0.34, −0.37 and −0.32); no significant correlation was found for the AX halo features. Halo sign was present in 94% of first disease relapses but with a lower mean number of segments with halo and sum of halo IMT compared with disease onset (2.93±1.59 mm vs 4.85±1.51 mm, p=0.0012; 2.01±1.13 mm vs 4.49±1.95 mm, p=0.0012). Conclusions Ultrasound is a useful imaging tool to assess disease activity and response to treatment in patients with GCA.
Exploring the Cord Blood T Cell Compartment with Mass Cytometry Reveals the Existence of Memory CD4, CD8 and Regulatory T Cell Pools in the Fetal Period
Authors: Muharrem Muftuoglu, Li Li, Juan Jimenez, Duncan Mak, Jared K Burks, Bingqian Hu, Hila Shaim, Nobuhiko Imahashi, Francesca Lorraine Wei Inng Lim, Pinaki P Banerjee, Mustafa H Bdiwi, Lucila Nassif Kerbauy, Mecit Kaplan, Darius Armstrong James, Richard E Champlin, Elizabeth J Shpall, Katayoun Rezvani
Journal: Blood (2017)
A Clinical Approach to Preventing Death on the Streets
Authors: Katherine A. Koh, Jill S. Roncarati, James J. O’Connell
Journal: JAMA Internal Medicine (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Characterization of Streptococcus pneumoniae detected in clinical respiratory tract samples in southern Sweden 2 to 4 years after introduction of PCV13
Authors: Fabian Uddén, Elisabeth Rünow, Hans-Christian Slotved, Kurt Fuursted, Jonas Ahl, Kristian Riesbeck
Journal: Journal of Infection (2021)

To determine the serotype distribution and antimicrobial resistance of Streptococcus pneumoniae associated with mucosal infections in patients of all ages, 2 to 4 years after the transition from a 10-valent pneumococcal conjugate vaccine (PCV10) to PCV13 in the childhood immunization programme.Background information and antimicrobial susceptibility data regarding all respiratory tract, middle ear, and conjunctival samples positive for growth of S. pneumoniae (n = 2,131) were collected during 18 months in 2016-2018. Available corresponding bacterial isolates were serotyped by PCR and/or antisera (n = 1,858).In total, 17% of isolates were covered by PCV13, predominantly represented by serotypes 3 (9%) and 19A (5%). The most common nonvaccine serotypes were 11A (10%), 23B (10%), 15A (6%) and 35F (5%). Isolates exhibiting serotype 15A or 23B were often multidrug-resistant (21%) or penicillin nonsusceptible (38%), respectively.The overall proportion of serotype 19A was halved compared to a previous observation period when PCV10 was used (years 2011-2013), suggesting herd protection related to PCV13. The proportion of serotype 3 was, however, unchanged. Despite most nonvaccine serotypes causing mucosal infections have a low invasive potential, certain antibiotic resistant serotypes may pose a clinical problem.
Electrode Materials for Chronic Electrical Microstimulation
Authors: Xin Sally Zheng, Chao Tan, Elisa Castagnola, Xinyan Tracy Cui
Journal: Advanced Healthcare Materials (2021)

Electrical microstimulation has enabled partial restoration of vision, hearing, movement, somatosensation, as well as improving organ functions by electrically modulating neural activities. However, chronic microstimulation is faced with numerous challenges. The implantation of an electrode array into the neural tissue triggers an inflammatory response, which can be exacerbated by the delivery of electrical currents. Meanwhile, prolonged stimulation may lead to electrode material degradation., which can be accelerated by the hostile inflammatory environment. Both material degradation and adverse tissue reactions can compromise stimulation performance over time. For stable chronic electrical stimulation, an ideal microelectrode must present 1) high charge injection limit, to efficiently deliver charge without exceeding safety limits for both tissue and electrodes, 2) small size, to gain high spatial selectivity, 3) excellent biocompatibility that ensures tissue health immediately next to the device, and 4) stable in vivo electrochemical properties over the application period. In this review, the challenges in chronic microstimulation are described in detail. To aid material scientists interested in neural stimulation research, the in vitro and in vivo testing methods are introduced for assessing stimulation functionality and longevity and a detailed overview of recent advances in electrode material research and device fabrication for improving chronic microstimulation performance is provided.
Cow’s Milk Is Not Ideal for Children at Any Age
Authors: Susan M. Levin, Neal D. Barnard
Journal: JAMA Pediatrics (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Attenuating CD3 affinity in a PSMAxCD3 bispecific antibody enables killing of prostate tumor cells with reduced cytokine release
Authors: Kevin Dang, Giulia Castello, Starlynn C Clarke, Yuping Li, Aarti Balasubramani, Andrew Boudreau, Laura Davison, Katherine E Harris, Duy Pham, Preethi Sankaran, Harshad S Ugamraj, Rong Deng, Serena Kwek, Alec Starzinski, Suhasini Iyer, Wim van Schooten, Ute Schellenberger, Wenchao Sun, Nathan D Trinklein, Roland Buelow, Ben Buelow, Lawrence Fong, Pranjali Dalvi
Journal: Journal for ImmunoTherapy of Cancer (2021)

Therapeutic options currently available for metastatic castration-resistant prostate cancer (mCRPC) do not extend median overall survival >6 months. Therefore, the development of novel and effective therapies for mCRPC represents an urgent medical need. T cell engagers (TCEs) have emerged as a promising approach for the treatment of mCRPC due to their targeted mechanism of action. However, challenges remain in the clinic due to the limited efficacy of TCEs observed thus far in solid tumors as well as the toxicities associated with cytokine release syndrome (CRS) due to the usage of high-affinity anti-CD3 moieties such as OKT3.
Icelandic study of cutaneous squamous cell carcinoma (cSCC) epidemiology highlights the worldwide burden of disease and challenges of <i>in situ</i> and invasive cSCC registry data
Authors: Z.C. Venables
Journal: British Journal of Dermatology (2021)

Linked Article: Adalsteinsson et al. Br J Dermatol 2021; 185:537–547.
POS1250 VITAMIN D DEFICIENCY IS MAINLY ASSOCIATED WITH SEVERE LUNG INVOLVEMENT, LONGER DISEASE DURATION AND RISK OF DEATH IN ELDERLY COVID-19 PATIENTS
Authors: A. Sulli, E. Gotelli, A. Casabella, M. Grosso, C. Schenone, C. Pizzorni, S. Paolino, E. Alessandri, V. Smith, M. Cutolo
Journal: Annals of the Rheumatic Diseases (2021)

Background: Vitamin D regulates the innate and adaptive immune system responses and low vitamin D levels have been associated with the increased risk of respiratory tract infections (1). Vitamin D deficiency has been recently reported to interfere with the prognosis of COVID-19 (2,3). Objectives: The aim of this study was to correlate the 25OH-vitamin D serum levels with lung involvement and disease severity, in a cohort of elderly patients hospitalized for SARS-CoV-2 infection. Methods: Sixty-five COVID-19 patients (mean age 76±13 years) and sixty-five sex- and age-matched control subjects (CNT) were included in the study. Respiratory parameters (PaO 2 , SO 2 , PaCO 2 , PaO 2 /FiO 2 ), clinical and laboratory parameters (including 25OH-vitamin D, D-dimer, C-reactive protein) and type of radiological pulmonary involvement were collected at hospital admission. Statistical analysis was performed by non-parametric tests. Results: Vitamin D sufficiency (&gt;30 ng/ml), insufficiency (between 20 and 30 ng/ml), deficiency (between 10 and 20 ng/ml) and severe deficiency (&lt;10 ng/ml) were observed respectively in 11, 11, 21 and 57 % of COVID-19 patients. Vitamin D serum levels were found significantly lower in COVID-19 patients than in CNT (median 8 vs 16 ng/ml, p=0.001). A statistically significant positive correlation was observed between vitamin D serum levels and SO 2 (p=0.05), PaO 2 (p=0.03), PaO 2 /FiO 2 (p=0.02). A statistically significant negative correlation was found between vitamin D serum levels and severity of radiologic pulmonary involvement: vitamin D was significantly lower in COVID-19 patients with either diffuse/severe interstitial lung involvement (p=0.05) or multiple lung consolidations (p=0.0001) than in those with mild radiological lung involvement. Significantly lower vitamin D serum levels were found in COVID-19 patients who died during hospitalization, compared to those who survived (median 3 vs 8 ng/ml, p=0.05). Finally, a statistically significant negative correlation was found between vitamin D serum levels and D-dimer (p=0.04), C-reactive protein (p=0.04) and disease duration (p=0.05). Conclusion: This study confirms that severe vitamin D deficiency is associated with more severe lung involvement, longer disease duration and risk of death in elderly COVID-19 patients. References: [1]Cutolo M, et al. RMD Open. 2020; 6(3):e001454. [2]Bilezikian JP, et al. Eur J Endocrinol. 2020; 183(5):R133-R147. [3]Weir EK, et al. Clin Med (Lond). 2020; 20:e107-e108. Disclosure of Interests: None declared
Cathepsin G Is Expressed By B Cell Acute Lymphoblastic Leukemia and Is an Effective Immunotherapeutic Target
Authors: Maliha Khan, Selena Carmona, Pariya Sukhumalchandra, Yihua Qiu, Alexander Perakis, Mao Zhang, Madhushree Zope, Anne Philip, Abdul Shah, Na Qiao, Lisa St. John, Jonathan Goldberg, Elizabeth Mittendorf, Jeffrey J. Molldrem, Steven Kornblau, Gheath Alatrash
Journal: Blood (2017)
Learning word order: early beginnings
Authors: Irene de la Cruz-Pavía, Caterina Marino, Judit Gervain
Journal: Trends in Cognitive Sciences (2021)

We examine the beginning of the acquisition of the relative order of function and content words, a fundamental but cross-linguistically highly variable aspect of grammar. A review of the existing empirical literature shows that infants as young as 8 months of age can distinguish between functors and content words, and have a rudimentary knowledge of the order of these two universal lexical categories in their native language. Furthermore, human adults and non-human animals such as rodents process the same linguistic information differently from infants, emphasizing the developmental relevance of bootstrapping function/content word order from surface cues available in the input. We discuss the implications of these findings for a synergistic view of language acquisition, considering how grammar acquisition interacts with word learning.
Lung Health Disparities in Time
Authors: Emily Brigham, Sarath Raju
Journal: JAMA Internal Medicine (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal