tbuckley/cabot-search huggingface dataset:
CD19-directed chimeric antigen receptor T cell therapy in Waldenström macroglobulinemia: a preclinical model and initial clinical experience
Authors: M Lia Palomba, David Qualls, Sebastien Monette, Shenon Sethi, Ahmet Dogan, Mikhail Roshal, Brigitte Senechal, Xiuyan Wang, Isabelle Rivière, Michel Sadelain, Renier J Brentjens, Jae H Park, Eric L Smith
Journal: Journal for ImmunoTherapy of Cancer (2022)

Background Waldenström macroglobulinemia (WM) is an incurable disease and, while treatable, can develop resistance to available therapies and be fatal. Chimeric antigen receptor (CAR) T cell therapy directed against the CD19 antigen has demonstrated efficacy in relapsed or refractory B lymphoid malignancies, and is now approved for B cell acute lymphoblastic leukemia and certain B cell lymphomas. However, CAR T therapy has not been evaluated for use in WM. Methods and results We performed preclinical studies demonstrating CAR T cell activity against WM cells in vitro, and developed an in vivo murine model of WM which demonstrated prolonged survival with use of CAR T therapy. We then report the first three patients with multiply relapsed and refractory WM treated for their disease with CD19-directed CAR T cells on clinical trials. Treatment was well tolerated, and observed toxicities were consistent with those seen in CAR T treatment for other diseases, and no grade 3 or higher cytokine release syndrome or neurotoxicity events occurred. All three patients attained at least a clinical response to treatment, including one minimal residual disease-negative complete response, though all three eventually developed recurrent disease between 3 and 26 months after initial treatment. Conclusions This report summarizes preclinical and clinical activity of CD19-directed CAR T therapy in WM, demonstrating early tolerability and efficacy in patients with WM, and representing a possible treatment option in patients with heavily pretreated and relapsed or refractory WM. Larger studies evaluating CAR T therapy in WM are warranted, along with further evaluation into mechanisms of resistance to CAR T therapy.
CORRECTION
Journal: JAMA (1927)

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Intracranial Aneurysms
Authors: W. R. Henderson, D. S. Mehta
Journal: BMJ (1973)

A reappraisal of case histories of patients with ruptured intracranial aneurysms emphasized the importance of clinically recognizing severe spasm that contraindicates early angiography and large cerebral haematomas that require immediate evacuation. Observation from the day of haemorrhage is important; most recurrent episodes with cerebral signs in the first 10 days were due to spasm; haemorrhage was more common during the following two weeks. In many attacks the signs were not sufficiently distinctive for diagnosis of spasm or haematoma.
Questions and Answers
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dobutamine echocardiography for prediction of sudden arrythmic death in patients with ischemic cardiomyopathy Azad Raiesdana, Teri Greco, Jeff Howard, Irmina Gradus-Pizlo, Adam Greene, Judy Foltz, Naomi Fineberg, Harvey Feigenbaum, Stephen Sawada. Indiana University School of Medicine, Indianapolis, IN
Journal: Journal of the American College of Cardiology (2001)
Cor triatriatum.
Authors: L K Lacquet, J A Los, J Nauta, A G Brom
Journal: Thorax (1966)

Cor triatriatum is a malformation of the heart in which the left atrium is divided into two compart- ments by an abnormal transverse or oblique septum.The postero-superior compartment receives the pulmonary veins, and the antero- inferior compartment comprises the left auricle and connects with the mitral orifice.The com- munication between the two compartments varies greatly.True cor triatriatum is rare.In the necropsy material of 1,000 congenital heart defects, Abbott (1946) found only seven cases of cor triatriatum but 17 cases in which the left atrium contained abnormal adhesions or bands.Niwayama (1960) found four cases in 3,740 necropsies carried out from 1936 to 1958.Until a few years ago cor triatriatum was of interest only to the pathologist.But the number of clinical observations has increased since surgical correction has become possible.In 1952 Barnes and Finlay pointed out that this anomaly is amenable to surgical correc- tion.The first successful operations were per- formed by Lillehei and Lewis (1955), Vineberg and Gialloreto (1956), and Barrett and Hickie (1957).We present four cases of cor triatriatum which received successful surgical treatment in our clinic.The anomaly was diagnosed pre-operatively in two cases.The third was operated upon for an atrial septal defect of the dorsal (secundum) type with mild mitral stenosis ; the initial diagnosis in the fourth case was atrial septal defect.
Psychological relativity
Authors: Donald Laming
Journal: Behavioral and Brain Sciences (2003)

“Psychological relativity” means that “an observation is a relationship between the observer and the event observed.” It implies a profound distinction between “the internal first-person as opposed to the external third-person perspective.” That distinction, followed through, turns Lehar's discourse inside-out. This commentary elaborates the notion of “psychological relativity,” shows that whereas there is already a natural science of perceptual report, there cannot also be a science of perception per se, and draws out some implications for our understanding of phenomenal consciousness.
Familial dysautonomia.
Authors: A. A. Smith
Journal: BMJ (1968)

cover, or that loose or infected teeth were involved ?If the treatment provided was only fillings performed in a sound mouth would the authors consider that the relation- ship of dental treatment to the onset of the disease might be fortuitous, especially since it was not possible to isolate the causative organisms to give further evidence ?The answer to this question is of great importance in view of the number of patients for whom dental surgeons routinely provide an antibiotic umbrella before the removal of teeth, but not before filling them.-Iam, etc.,
Hyperuricemia During Total Fasting
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cope's Early Diagnosis of the Acute Abdomen
Authors: Lloyd M. Nyhus
Journal: JAMA (1996)

This is the 19th edition of this well-known text, which was first published in 1921 by Zachary Cope. The emphasis upon the clinical (nonlaboratory) approach to the correct early diagnosis of this common affliction has been maintained during the past five revisions by William Silen of Boston. In the current era of technological advances, there is a tendency to shun details of the history and physical examination prior to obtaining and attempting to interpret one or more of these new and expensive visualizations of body regions. While recognizing the value of fine-tuning the diagnosis with these newer techniques, Silen has maintained the major thrust or core of his presentation as the tried and true nuances of the history and physical examination outlined so succinctly by Zachary Cope. To assure that his readers are cognizant of the plethora of tests currently available to the clinician, Silen includes a chapter outlining them
Medication–Associated Phthalate Exposure and Childhood Cancer Incidence
Authors: Thomas P Ahern, Logan G Spector, Per Damkier, Buket Öztürk Esen, Sinna P Ulrichsen, Katrine Eriksen, Timothy L Lash, Henrik Toft Sørensen, Deirdre P Cronin-Fenton
Journal: JNCI Journal of the National Cancer Institute (2022)

Human phthalate exposure is widespread through contact with myriad consumer products. Exposure is particularly high through medications formulated with phthalates. Phthalates disrupt normal endocrine signaling and are associated with reproductive outcomes and incidence of some cancers. We measured associations between gestational and childhood medication-associated phthalate exposures and the incidence of childhood cancers.We identified all live births in Denmark between 1997 and 2017, including both children and birth mothers. Using drug ingredient data merged with the Danish National Prescription Registry, we measured phthalate exposure through filled prescriptions for mothers during pregnancy (gestational exposure) and for children from birth until age 19 years (childhood exposure). Incident childhood cancers were ascertained from the Danish Cancer Registry, and associations were estimated with Cox regression models.Among 1 278 685 children, there were 2027 childhood cancer cases diagnosed over 13.1 million person-years of follow-up. Childhood phthalate exposure was strongly associated with incidence of osteosarcoma (hazard ratio [HR] = 2.78, 95% confidence interval [CI] = 1.63 to 4.75). We also observed a positive association with incidence of lymphoma (HR = 2.07, 95% CI = 1.36 to 3.14), driven by associations with Hodgkin and non-Hodgkin lymphoma but not Burkitt lymphoma. Associations were apparent only for exposure to low-molecular phthalates, which have purportedly greater biological activity.Childhood phthalate exposure was associated with incidence of osteosarcoma and lymphoma before age 19 years. Lingering questions include which specific phthalate(s) are responsible for these associations, by what mechanisms they occur, and to what extent childhood cancer cases could be avoided by reducing or eliminating the phthalate content of medications and other consumer products.
Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma
Authors: Xiao Zhang, Yunhua Xu, Lifang Ma, Keke Yu, Yongjie Niu, Xin Xu, Yi Shi, Susu Guo, Xiangfei Xue, Yikun Wang, Shiyu Qiu, Jiangtao Cui, Hong Wang, Xiaoting Tian, Yayou Miao, Fanyu Meng, Yongxia Qiao, Yongchun Yu, Jiayi Wang
Journal: Cancer Communications (2022)

Resistance to ferroptosis, a regulated cell death caused by iron-dependent excessive accumulation of lipid peroxides, has recently been linked to lung adenocarcinoma (LUAD). Intracellular antioxidant systems are required for protection against ferroptosis. The purpose of the present study was to investigate whether and how extracellular system desensitizes LUAD cells to ferroptosis.Established human lung fibroblasts MRC-5, WI38, and human LUAD H1650, PC9, H1975, H358, A549, and H1299 cell lines, tumor and matched normal adjacent tissues of LUAD, and plasma from healthy individuals and LUAD patients were used in this study. Immunohistochemistry and immunoblotting were used to analyze protein expression, and quantitative reverse transcription-PCR was used to analyze mRNA expression. Cell viability, cell death, and the lipid reactive oxygen species generation were measured to evaluate the responses to ferroptosis. Exosomes were observed using transmission electron microscope. The localization of arachidonic acid (AA) was detected using click chemistry labeling followed by confocal microscopy. Interactions between RNAs and proteins were detected using RNA pull-down, RNA immunoprecipitation and photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation methods. Proteomic analysis was used to investigate RNA-regulated proteins, and metabolomic analysis was performed to analyze metabolites. Cell-derived xenograft, patient-derived xenograft, cell-implanted intrapulmonary LUAD mouse models and plasma/tissue specimens from LUAD patients were used to validate the molecular mechanism.Plasma exosome from LUAD patients specifically reduced lipid peroxidation and desensitized LUAD cells to ferroptosis. A potential explanation is that exosomal circRNA_101093 (cir93) maintained an elevation in intracellular cir93 in LUAD to modulate AA, a poly-unsaturated fatty acid critical for ferroptosis-associated increased peroxidation in the plasma membrane. Mechanistically, cir93 interacted with and increased fatty acid-binding protein 3 (FABP3), which transported AA and facilitated its reaction with taurine. Thus, global AA was reduced, whereas N-arachidonoyl taurine (NAT, the product of AA and taurine) was induced. Notably, the role of NAT in suppressing AA incorporation into the plasma membrane was also revealed. In pre-clinical in vivo models, reducing exosome improved ferroptosis-based treatment.Exosome and cir93 are essential for desensitizing LUAD cells to ferroptosis, and blocking exosome may be helpful for future LUAD treatment.
Ganglia.
Authors: A W Fowler
Journal: BMJ (1977)

Our recent experience in San Francisco has been that intensive management of these small infants (500-1000 g birth weight) results in survival of more than 60 0 (see table ).Infants born outside the regional perinatal centre Neontatal mortality of infatnts of 500-1000 g birth zveio,ht admitted to intcnsivce care unit, San Francisco Children's Hovpital Inborni Outborn 'I'otal Year _ _
Queries and Minor Notes
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
International Association for the Study of Lung Cancer Study of the Impact of Coronavirus Disease 2019 on International Lung Cancer Clinical Trials
Authors: Matthew P. Smeltzer, Giorgio V. Scagliotti, Heather A. Wakelee, Tetsuya Mitsudomi, Upal Basu Roy, Russell C. Clark, Renee Arndt, Clayton D. Pruett, Karen L. Kelly, Peter Ujhazy, Melissa L. Johnson, Yesim Eralp, Carlos H. Barrios, Fabrice Barlesi, Fred R. Hirsch, Paul A. Bunn
Journal: Journal of Thoracic Oncology (2022)
Ectopic Pregnancy
Authors: David A. Eschenbach
Journal: JAMA (1983)

Two reports (pp 1725 and 1730) in this issue again emphasize the dramatic increase in the number of ectopic pregnancies that have been diagnosed during the past ten to 20 years. A twofold increase in the rate of ectopic pregnancy has been documented during the last ten-year period, and rates generally have been rising at an even faster pace during the past five years.<sup>1-4</sup>This increase in ectopic rates has occurred among a wide variety of populations in many industrialized countries. The annual number of ectopic pregnancies in the United States is now estimated to be 40,000, compared with 15,000 to 18,000 during the years 1965 to 1970.<sup>4</sup>The occurrence of this large number of ectopic pregnancies represents a tremendous amount of morbidity for women in the reproductive age group. The presence of an ectopic pregnancy subjects the woman to the uncertainties of intra-abdominal bleeding, the performance of
New Treatments Emerge for RCC
Journal: Cancer Discovery (2021)

Abstract Two trials could change clinical practice for certain subtypes of renal cell carcinoma (RCC). In one, the combination of lenvatinib and pembrolizumab was superior to sunitinib and to lenvatinib plus everolimus in clear-cell RCC. In the other, cabozantinib was more effective than sunitinib in papillary RCC.
THE DISTRIBUTION OF METABOLITES IN THE BODY
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Visceral Pain
Authors: J. Morley
Journal: BMJ (1937)

BRITISHquinsy; also for those minor surgical operations asso- ciated with midwifery, when the more elaborate apparatus required for the administration of nitrouLs oxide and oxygen or cyclopropane is not available.Cyclopropane (C3H6) This comparatively new anaesthetic has a definite place in anaesthesia for minor surgery, as premedication can be dispensed with entirely, although it is an advantage to administer small doses such as 1 / 100 grain of atropine and 1/6 grain of morphine.It is not unpleasant from the patient's point of view, and any stage of anaesthesia required can be quickly and easily produced, although the profound relaxation of deep ether or spinal anaesthesia cannot be obtained.Complete and absolute recovery with cyclopropane is rapid; post-operative complications are rare, with the exception of vomiting, which, strange to relate, is usually unassociated with nausea and does not distress the patient to any extent.Cyclopropane cannot be classified as an entirely safe anaesthetic, although, unlike chloroform, some warning of impending disaster is certainly given by failure of respira- tion, rapidly increasing pulse rate, or a pulse rate below 50; but, owing to its quick elimination, it is easy, by washing out or diluting the anaesthetic with oxygen, to get the patient to a lighter and safer plane of anaesthesia.The high cost of this gas makes it essential that it be administered always by a close-circuit system, of which there is no standard pattern in Britain at the moment; but many types of apparatus are being experimented with, and it is possible that in the near future an apparatus which is easily portable, efficient, and moderately inex- pensive will be on the market. Conclusion
Criteria for the diagnosis of alcoholism
Authors: F. A. Seixas
Journal: JAMA (1972)

It has been a historic mission of national voluntary health organizations to provide diagnostic and classificatory standards for the diseases in which their interest lies. Thus we have the Jones Criteria for rheumatic fever, the American Heart Association's criteria for classifying heart disease and, more recently, kidney disease, the diagnostic classification for tuberculosis developed by the American Tuberculosis and Respiratory Disease Association, and many others. One disease that up to now has not had this kind of attention has been alcoholism, and the need for clarification of what we mean when a diagnosis of alcoholism is to be made has been urgent. The need is exemplified by the statement in the Supreme Court case, Powell vs Texas, which held that there was no "substantial consensus as to the 'manifestations of alcoholism.'" It turns out that it has been possible to obtain a rather strong agreement as to the meanings and