tbuckley/cabot-search huggingface dataset:
Adherence to Mismatch Repair Testing Guidelines in PT1 Colorectal Carcinomas Diagnosed Before the age of 70 Years
Authors: B Ykema, I Nagtegaal, K Kuhlmann, A van Berkel, M van Leerdam, T Dutch
Journal: Endoscopy (2021)

Aims Mismatch repair (MMR) testing is recommended in the Netherlands for all patients under 70 years of age with newly diagnosed colorectal cancer (CRC) in order to identify Lynch syndrome. T1 CRC can be removed by local excision or oncological surgical resection. We evaluated the frequency of MMR testing in pT1 lesions within the Dutch CRC screening cohort.
Effects of oral disopyramide phosphate on induction of paroxysmal supraventricular tachycardia.
Authors: SSwiryn, R ABauernfeind, C RWyndham, R CDhingra, EPalileo, BStrasberg, K MRosen
Journal: Circulation (1981)

The effects of oral disopyramide phosphate on laboratory induction of paroxysmal supraventricular tachycardia (PSVT) were studied in 16 patients with clinical PSVT. After control electrophysiologic study to determine the inducibility and mechanism of PSVT, patients were given 200-300 mg (275 +/- 45 mg, mean +/- SD) of disopyramide for three to five doses over 24 hours and were then restudied. All patients had inducible, sustained PSVT during the control study. After disopyramide, PSVT was noninducible in eight patients (50%), including six of nine with atrioventricular nodal reentrance and two of seven with atrioventricular reentrance; inducible but nonsustained in two (12.5%) (both with atrioventricular reentrance); and inducible and sustained in six (37.5%). The benefit of disopyramide seemed predominantly to reflect depression of conduction in the retrograde limb of the circus movements, although effects upon the antegrade limb were also observed. In the eight patients with inducible PSVT before and af...
The Appearance of Sjögren Syndrome on 68Ga-PSMA-11 PET/CT
Authors: Rou Li, Danni Li, Xiao Li, Changjing Zuo, Chao Cheng
Journal: Clinical Nuclear Medicine (2021)

Significant 68Ga-PSMA-11 activity is commonly observed in the lacrimal and salivary glands on PSMA PET/CT. An 80-year-old man after radical prostatectomy was evaluated with 68Ga-PSMA-11 PET/CT. There was no obvious PSMA uptake in the bilateral lacrimal, parotid, and submandibular glands. Subsequently, based on laboratory examination results and 99mTcO4 salivary gland scintigraphy, this patient was diagnosed with Sjögren syndrome, which accounted for the absence of uptake by the glands. This case showed the potential of 68Ga-PSMA-11 PET/CT in the evaluation of the lacrimal glands and major salivary glands.
Diagnostic Accuracy Of Applying The Wasp Classification To Blue Light Imaging And Linked Color Imaging For Real-Time Colorectal Polyp Charaterisation
Authors: BBSL Houwen, JLA Vleugels, M Pellisé, L Rivero-Sánchez, F Balaguer, R Bisschops, S Tejpar, A Repici, D Ramsoekh, MAJM Jacobs, RM Schreuder, MF Kamiński, M Rupińska, P Bhandari, MGH van Oijen, L Koens, BAJ Bastiaansen, KMAJ Tytgat, P Fockens, E Dekker, Y Hazewinkel
Journal: Endoscopy (2021)

Aims The Workgroup SerrAted polypS and Polyposis (WASP) classification for endoscopic characterisation of colorectal polyps has been validated using Narrow Band imaging (NBI) technology, leaving uncertainty regarding its applicability to other imaging techniques. The aim of this study was to address the diagnostic accuracy of real-time polyp characterisation applying the WASP classification to Blue Light imaging (BLI), Linked Color imaging (LCI) and high-definition white light endoscopy (HD-WE).
Controlled trial of Penfluridol in Acute Psychosis
Authors: H. M. van Praag, T. Schut, L. Dols, R. van Schilfgaarden
Journal: BMJ (1971)

A controlled study was made of penfluridol medication consisting of a single weekly oral dose of 30 mg in 30 patients with acute psychoses of varying type and origin. This medication was found to be effective. No significant side effects occurred. Several long-acting neuroleptics for injection are now available. The development of an oral compound of this type is an asset because of the manageability of the oral drug in the hands of family doctors and social psychiatrists.
Validation of a Novel AI System (CADEYE) for in VIVO Characterization of Colorectal POLYPS
Authors: M Abdelrahim, E Hossain, S Subramaniam, P Bhandari
Journal: Endoscopy (2021)

Aims The aim of this study is to evaluate the diagnostic performance of a novel artificial intelligence system for characterization of colorectal polyps and compare its performance to endoscopists.
Subacute Bacterial Endocarditis
Authors: R. V. Christie
Journal: BMJ (1953)

The effective use of antibiotics has not only changed the prognosis and clinical course of subacute bacterial endocarditis but has entirely altered the emphasis on early diagnosis.Ten years ago the diagnoWis was seldom made until the disease was well established, while today any patient with a heart murmur and unexplained fever should be suspect.In my own wards patients suf- fering from rheumatic fever, cystitis, glandular fever, virus pneumonia, carcinoma of the stomach, periarteritis nodosa, haemolytic anaemia, and perianal abscess have been admitted with the diagnosis of sub- acute bacterial endocarditis, and in each case, although the initial diagnosis was shown to be wrong, the admis- sion of the patient to hospital should be taken as evidence of good judgment and efficiency on the part of the general practitioner involved.Early diagnosis is of great importance to the patient, therefore a full investi- gation is indicated when subacute bacterial endocarditis is first suspected.
Clinical, angiographic, and hemodynamic findings in patients with anomalous origin of the coronary arteries.
Authors: B RChaitman, JLespérance, JSaltiel, M GBourassa
Journal: Circulation (1976)

Clinical and angiographic features of 31 patients with anomalous coronpary artery origin are reviewed. Of 17 aberrant circumflex arteries from the right sinus of Valsalva or artery, each was retro-aortic, six atherosclerotic, and seven irrigated a small area of myocardium. Of seven anomalous right coronary arteries from the left sinus of Valsalva or artery, each was ante-aortic and two atherosclerotic. Aberrant origin of the circumflex or right coronary artery was a benign anomaly. The proximal course of seven aberrant left coronary arteries from the right sinus of Valsalva or right coronary artery was related to clinical events. The anomaly was best demonstrated in the lateral view. In five cases, coronary blood flow during exercise and myocardial metabolism during pacing were assessed. Two had had a previous infarction with nonatherosclerotic arteries. Exercise coronary blood flow was normal in four and low in one patient. Pacing resulted in lactate production in two with atherosclerotic and one without...
Comparative sensitivity of exercise, cold pressor and ergonovine testing in provoking attacks of variant angina in patients with active disease.
Authors: D DWaters, JSzlachcic, RBonan, D DMiller, FDauwe, PTheroux
Journal: Circulation (1983)

Exercise, ergonovine and the cold pressor test have been used to provoke variant angina attacks. The sensitivity of these three tests was compared in 34 hospitalized patients with well documented, active variant angina who had recently undergone coronary arteriography. The three tests were usually performed on three consecutive days, and 28 of the 34 had the three tests within 1 week. Angina was provoked by ergonovine in all 34 patients, by exercise in 17 and by cold pressor test in only five (p less than 0.005). ST elevation developed during the ergonovine test in 32 (94%), during exercise in 10 (29%) and during the cold pressor test in only three (9%). With ergonovine, one patient had only ST depression and one had no ECG changes. During the cold pressor test two patients had pseudonormalization of abnormally negative T waves and 29 had no ECG changes. Exercise induced T-wave pseudonormalization in four patients, ST depression in nine others and no ECG changes in 11. ST elevation was more frequent with ...
EPR and fluorescence depolarization studies on bovine cardiac myosin.
Authors: D BStone, R AMendelson, JBotts, P HCheung
Journal: Circulation Research (1981)

To test for possible differences in local conformation and S1 flexibility, bovine cardiac and rabbit skeletal myosins were labeled with a fluorophore (1,5-IAEDANS) and a spin label having iodoacetamide reactivity. The marked activation of the Ca2+-ATPase (6- to 8-fold) and inhibition of the K+ (EDTA)-ATPase (80-90%) by both labels indicated specific labeling of the fast-reacting thiols (SH1) of both myosins. Fluorescence depolarization studies of 1,5-IAEDANS-labeled cardiac myosin indicated that, like skeletal myosin, the SI moieties of cardiac myosin exhibit considerable segmental flexibility with respect to the rod portion of the molecule. This indicates that segmental flexibility may be a property of all myosins. Cardiac and skeletal myosins immobilized spin labels to approximately the same extent, indicating a similarity in steric restraints around the SH1 thiol of the two myosins. The magnitude of the changes in spin label mobility accompanying binding of MgADP and hydrolysis of MgATP was reduced in ...
Percutaneous Transhepatic Cholangioscopy - An Option For The Treatment Of Intrahepatic Lithiasis
Authors: C Correia, MJ Cardoso, N Almeida, M Duque, AG Agostinho, H Alexandrino, P Figueiredo
Journal: Endoscopy (2021)

Aims Stenosis of hepaticojejunostomy (HJ) is a potentially serious postoperative complication after pancreaticoduodenectomy (PD). It causes biliary stasis leading to intrahepatic lithiasis and recurrent cholangitis.
Successful Rectal ESD for a Large Flat Rectal Adenoma With The Application Of Scissor-Type SB Knife and Dual Endoscopic Technique for Triangulation-a Video Case Report
Authors: L Madacsy, A Finta, BD Lovasz, L Oczella, M Szalai
Journal: Endoscopy (2021)

Endoscopic submucosal dissection (ESD) for superficial gastrointestinal neoplasms has become a gold standard procedure. Scissor-type ESD knife enables the performance of all ESD techniques, including mucosal incision, submucosal dissection, and hemostasis. We demonstrate a video case of a young female patient suffering from a flat type sessile serrated rectal adenoma with LGD (IIa-LST-NG) complicated with significant submucosal scarring. After circumferential marking with Q-type-clear-cut-knife (Finemedix) and sequential submucosal injection of 50 ml Eleview we performed an R0, one-piece ESD of the 35x45 mm-large lesion with scissor-type SB-Jr-knife (Sumitomo). We completed the resection with a second endoscope assisted triangulation within 155 min.
The Injuries to JFK
Authors: Clyde W. Howard
Journal: JAMA (1992)

To the Editor.  —I have recently read the articles 1,2 and the Editorial 3 in your May 27, 1992, issue of JAMA concerning the John F. Kennedy autopsy controversy. I would say, as a citizen and an attorney, that you have done a signal service in obtaining and publishing the interviews. I feel that the nation owes you a genuine vote of thanks, which you will probably not get. I also feel that the comment that One might think that all this demonstration of facts and expression of expert medical opinion would end the controversy over the President's autopsy, but one would probably be wrong is unfortunately very likely to be accurate.  We set ourselves up for conspiracy theories, based on anything from misapprehension to flat-out personal greed, by the failure to be completely open in the handling of the autopsy—but I also think that it was inevitable that mistakes
The AMA, tobacco, and the public health
Authors: L. Emanuel
Journal: JAMA (1996)

To the Editor.  —Your devotion of an entire issue of JAMA to the murderous secret of Brown and Williamson is appropriate. 1 Top-quality research confirming the addictive nature of nicotine and the carcinogenic nature of tobacco was suppressed for the sake of the industry's financial interest. Counteraction is due.  Along with the actions you list to counter the tobacco industry influence, the medical world should publicly appeal to pharmacists and pharmacies to eschew sale of tobacco on their premises. It is astonishing that the source of curative products should be simultaneously selling addictive poisons. The tobacco industry must revel in the implicit endorsement brought by the juxtaposition of medicines with their packets of cigarettes.  But there is another lesson in the Brown and Williamson exposure. In recent months, there have been wholesale attacks on government-funded medical research programs. The justification is generally that public money should not go to science;
Ethical Principles for Everyone
Authors: Nelson G. Goodman
Journal: Annals of Internal Medicine (2001)

Letters19 June 2001Ethical Principles for EveryoneNelson G. Goodman, MDNelson G. Goodman, MDMaryland Citizens Health Initiative; Baltimore, MD 21218 (Goodman)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-12-200106190-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Dr. Davidoff's editorial discussing the ethical principles proposed by the Tavistock group included the “right to health and health care” (1). This was opportune for the Maryland Citizens Health Initiative, which met in September 2000 with the leadership of the Maryland chapter of the American College of Physicians–American Society of Internal Medicine. Our purpose was to gain further support for a grassroots effort to provide comprehensive health insurance for all residents of our state.The Maryland Citizens Health Initiative was formed in the spring of 1999 under the leadership of Peter Beilenson, Commissioner of Health of Baltimore ...References1. Davidoff F. Changing the subject: ethical principles for everyone in health care [Editorial]. Ann Intern Med. 2000;133:386-9. [PMID: 0010979885] LinkGoogle Scholar2. DeMarco V, Schneider GE. Elections and public health [Editorial]. Am J Public Health. 2000;90:1513-4. [PMID: 0011029979] CrossrefMedlineGoogle Scholar3. Scott HD, Shapiro HB. Universal insurance for American health care. A proposal of the American College of Physicians. Ann Intern Med. 1992;117:511-9. [PMID: 1503354] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Nelson G. Goodman, MDAffiliations: Maryland Citizens Health Initiative; Baltimore, MD 21218 (Goodman) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoChanging the Subject: Ethical Principles for Everyone in Health Care Frank Davidoff Ethical Principles for Everyone Frank Davidoff Ethical Principles for Everyone Joseph J. Mazza Ethical Principles for Everyone Alan R. Nelson Ethical Principles for Everyone Frédéric Pochard , Marc Grassin , and Elie Azoulay Metrics 19 June 2001Volume 134, Issue 12Page: 1152KeywordsAlcoholsHealth careHealth economicsHealth insuranceMedicarePediatricsPrevention, policy, and public healthPublic policyTaxes ePublished: 19 June 2001 Issue Published: 19 June 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The association between urinary sodium excretion and blood pressure in children.
Authors: RCooper, ISoltero, KLiu, DBerkson, SLevinson, JStamler
Journal: Circulation (1980)

This study explored the association between sodium excretion and blood pressure (BP). A new method was used to minimize the measurement error introduced by the large intrinsic variability of 24-hour sodium excretion. The ratio of intra- to interindividual variation was used to estimate the number of measurements needed to characterize the individual. When seven consecutive 24-hour samples were collected from 73 children, ages 11-14 years, a significant correlation between mean individual sodium excretion and BP was demonstrated. The independent relationship persisted when controlling for height, weight, pulse, age, sex and race (p = 0.045), but was eliminated by simultaneously considering mean creatinine excretion. Although the cross-sectional association described is quantitatively weak, a linear relationship between BP and sodium over the range consumed in this society could be important for prevention.
Effects of canagliflozin on myocardial infarction: a <i>post hoc</i> analysis of the CANVAS programme and CREDENCE trial
Authors: Jie Yu, Jingwei Li, Phillip J Leaver, Clare Arnott, Mark D Huffman, Jacob A Udell, Vlado Perkovic, Kenneth W Mahaffey, Dick de Zeeuw, Greg Fulcher, David R Matthews, Wayne Shaw, Norman Rosenthal, Bruce Neal, Gemma A Figtree
Journal: Cardiovascular Research (2021)

Abstract Aims Given the benefits of sodium glucose co-transporter 2 inhibition (SGLT2i) in protecting against heart failure in diabetic patients, we sought to explore the potential impact of SGLT2i on the clinical features of patients presenting with myocardial infarction (MI) through a post hoc analysis of CANVAS Programme and CREDENCE trial. Methods and results Individuals with type 2 diabetes and history or high risk of cardiovascular disease (CANVAS Programme) or type 2 diabetes and chronic kidney disease (CREDENCE) were included. The intervention was canagliflozin 100 or 300 mg (combined in the analysis) or placebo. MI events were adjudicated as ST-elevation myocardial infarction (STEMI), non-STEMI, and type 1 MI or type 2 MI. A total of 421 first MI events in the CANVAS Programme and 178 first MI events in the CREDENCE trial were recorded (83 fatal, 128 STEMI, 431 non-STEMI, and 40 unknown). No benefit of canagliflozin compared with placebo on time to first MI event was observed [hazard ratio (HR) 0.89; 95% confidence interval (CI) 0.75, 1.05]. Canagliflozin was associated with lower risk for non-STEMI (HR 0.78; 95% CI 0.65, 0.95) but suggested a possible increase in STEMI (HR 1.55; 95% CI 1.06, 2.27), with no difference in risk of type 1 or type 2 MI. There was no change in fatal MI (HR 1.22, 95% CI 0.78, 1.93). Conclusion Canagliflozin was not associated with a reduction in overall MI in the pooled CANVAS Programme and CREDENCE trial population. The possible differential effect on STEMI and Non-STEMI observed in the CANVAS cohort warrants further investigation. Trial registration ClinicalTrials.gov identifiers: NCT01032629, NCT01989754, and NCT02065791.
Dynamic intraventricular obstruction during dobutamine stress echocardiography. A new observation.
Authors: P APellikka, J KOh, K RBailey, B ANichols, K HMonahan, A JTajik
Journal: Circulation (1992)

BACKGROUNDThe implications of hypotension occurring during dobutamine stress echocardiography have not been elucidated. We observed in some patients that hyperdynamic left ventricular function developed during dobutamine stress echocardiography and hypothesized that intracavitary obstruction was occurring and might account for hypotension in some patients.METHODS AND RESULTSFifty-seven consecutive patients undergoing dobutamine stress echocardiography underwent pulsed-wave and continuous-wave Doppler examination of the left ventricular cavity at rest and at peak dobutamine infusion. The development of an intraventricular gradient with dobutamine stress was defined as a late-peaking left ventricular Doppler velocity profile that exceeded basal velocity by at least 1 m/sec. During dobutamine stress testing, left ventricular outflow velocity or intracavitary velocity increased in all patients. Obstruction occurred in 12 patients (21%, group 1). Group 2 was the remaining 45 patients. Peak velocities in group ...
Angiotensin II increases electrical coupling in mammalian ventricular myocardium.
Authors: KHermsmeyer
Journal: Circulation Research (1980)

Electrical measurements of current flow in ventricular myocardium immersed in silicone oil showed that angiotensin II increases the cell-to-cell spread of current within seconds. The increases in current spread and conduction velocity occur without any changes in resting membrane potential or maximum rate of rise of the action potential. The concentration range was 10 nM to 10 microM, with an ED50 of 100 nM for angiotensin exposures lasting about 10 seconds. The larges effects were an apparent decrease in resistance through the cellular pathway to 50% of control and a 40% increase in conduction velocity, which returned to control in about 15 minutes. Continuous or repeated exposure to angiotensin caused desensitization to appear. These effects were found with or without denervation by 6-hydroxydopamine and beta-adrenergic blockade by 1 microM propranolol in calf, pig, sheep, and rabbit ventricular myocardium. Therefore, angiotensin appears to increase electrical conduction rapidly and directly in cardiac ...
Electrophysiologic effects of nitroglycerin during experimental coronary occlusion.
Authors: RLevites, M MBodenheimer, R HHelfant
Journal: Circulation (1975)

Previous studies have shown that nitroglycerin (TNG) exerts beneficial electrophysiological effects in the setting of acute myocardial ischemia. To investigate the basis for these actions, the effects of TNG during coronary occlusion were studied in 19 anesthetized mongrel dogs. Refractory periods (obtained by extrastimulus method) and conduction times measured from local electrograms were determined in potentially ischemic and nonischemic areas prior to and after varying periods of occlusion of the left anterior descending coronary artery and following administration of TNG (300-400 mug intravenous bolus followed by an infusion titrated to reduce systolic blood pressure by 20 mm Hg). Following 15 minutes of occlusion, refractory periods in the ischemic zones shortened to 83% of control (P less than 0.001) resulting in a difference between refractory periods in the nonischemic and ischemic zones of 17.7%. After TNG administration this difference was decreased to 10.0% (P less than 0.001). However, with pe...
Dynamics of left ventricular filling at rest and during exercise.
Authors: J DCarroll, O MHess, H OHirzel, H PKrayenbuehl
Journal: Circulation (1983)

Left ventricular filling dynamics were examined at rest and during supine bicycle exercise in 33 patients at cardiac catheterization; 23 had coronary artery disease (ischemia group), five with prior infarction had an akinetic area at rest (scar group), and five had minimal cardiovascular disease (control). Peak filling rate and mean filling rate during the first half and second half of diastole were assessed by biplane angiography. Simultaneous micromanometer pressures were used to compute the time constant of isovolumic pressure decay (T). Peak filling rate and mean filling rate during the first half of diastole increased with exercise in all groups (from 615 to 1050 and 358 to 681 ml/sec in controls and comparably in the scar group and from 697 to 1035 and 347 to 768 ml/sec in the ischemia group). However, T was greater (reduced rate of pressure decay) with exercise in the ischemia group (38 vs 26 msec in controls; p less than .05). Changes in the atrial driving pressure for filling appeared to counterb...
Interstitial cells of the heart valves possess characteristics similar to smooth muscle cells.
Authors: D AFilip, ARadu, MSimionescu
Journal: Circulation Research (1986)

Interstitial cells of heart atrioventricular and sigmoid valves were examined in several laboratory animals (rabbit, hamster, rat, and mouse) and in humans. These cells constitute a large fraction of the total cell population of the valve; in mouse atrioventricular valves, they amount to approximately 30% of the volumetric density. By their ultrastructural features and functional properties, valvular interstitial cells are intermediate between fibroblasts and vascular smooth muscle cells. Like fibroblasts, valvular interstitial cells lack a basal lamina establishing direct and extensive contacts with collagen fibers, elastin microfibrils, and proteoglycans of the matrix. The cells have numerous slender and long processes, connected to one another, forming a complex cellular framework spanning the entire valve. Similar to smooth muscle cells, valvular interstitial cells are extensively coupled by communicating junctions as shown by thin sections, freeze-fracture, lanthanum staining, and carboxyfluorescein ...