tbuckley/cabot-search huggingface dataset:
Klima und Tuberkulose.
Authors: V. Conrad, Walther Hausmann, A. Bacmeister, H. Lossnitzer, Walter Behrend, M. Gähwyler
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 396: CaMKIIδ and PKD Overexpression seen in Heart Failure Maintains the HDAC5 Redistribution from the Nucleus to the Cytosol
Authors: Julie Bossuyt, Xu Wu, Metin Avkiran, Jody L Martin, Steven M Pogwizd, Donald M Bers
Journal: Circulation (2006)

Class II histone deacetylase (HDAC, e.g. HDAC5) nuclear export has been implicated in activation of gene transcription in hypertrophy & heart failure (HF). In normal rabbit myocytes we previously showed that endothelin-1 (ET-1) causes Ca release from nuclear envelope InsP 3 R and local CaMKII and PKD activation which cause HDAC5 nuclear export and MEF2 transcriptional activation. Here we tested whether this pathway is shifted in our non-ischemic rabbit HF model (where InsP 3 R2 and CaMKIIδ expression are elevated). Here we find a 2–3-fold increase in PKD expression and activation levels (measured by phosphorylation of PKD at S744/748 and CaMKII at T286) in HF (both rabbit and human). Basal HDAC5 was already more cytosolic in resting HF rabbit myocytes (F nuc /F cyto  3.3 + 0.3  vs . 7.2 ± 0.4 in control, Ctl) and in human HF HDAC5 was more highly phosphorylated. Despite this initial ratio, ET-1-induced HDAC5 nuclear export in HF (as %) was greater in HF (n nuc /F cyto  distribution of HDAC5-GFP in HF myocytes to that of Ctl cells (5.6 ± 0.4 and 6.3 ± 0.3), while blocking both fully restored the basal F nuc /F cyto  ratio (7.7 + 0.7). In Ctl adult myocytes we overexpressed (via adenovirus) PKD or CaMKIIδ isoforms and measured HDAC5 translocation. AdPKD, AdCaMKIIδ B  (nuclear) and AdCaMKIIδ C  (cytosolic) reduced basal Fnuc/Fcyto ratio to 3.4 + 0.5, 3.8 ± 0.5 and 5.2 ± 0.5 respectively (n=15). We conclude that in HF, the upregulation of CaMKIIδ; and PKD expression and activity contributes to a baseline shift in HDAC5 out of the nucleus (and also sensitize myocytes to neurohumoral-induced shifts). Furthermore, the consequent de-repression of transcription which results may reinforce the HF phenotype.
Abstract 995: Blockade Of Electron Transport Preserves The Contents Of Bcl-2 And Cytochrome <i>c</i> In Subsarcolemmal Mitochondria During Ischemia
Authors: Qun Chen, Edward J Lesnefsky
Journal: Circulation (2007)

Cardiac ischemia decreases the rate of oxidative phosphorylation (OXPHOS) and the contents of cardiolipin and cytochrome c (CYTc) in subsarcolemmal mitochondria (SSM) in the isolated rabbit heart. CYTc release first requires damage to the inner mitochondrial membrane to delocalize CYTc to the intermembrane space, followed by breach of the outer membrane. The decrease in cardiolipin content allows CYTc detachment from the inner membrane. It is still unclear how CYTc passes the outer membrane for release into cytosol. We propose that ischemia increases outer-membrane leakage by depletion of bcl-2 content, and that oxidants generated by the electron transport chain (ETC) during ischemia favor bcl-2 depletion. We used blockade of the proximal ETC at complex I during ischemia with amobarbital (AMO) to test the role of ETC during ischemia. Langendorff perfused rabbit hearts were treated with AMO (2.5 mM for 1 min) or vehicle immediately before 30 min global ischemia (37°C). Time controls were perfused for 45 min. SSM were isolated at the end of ischemia. CYTc content (reduced minus oxidized spectra), OXPHOS and bcl-2 (western blotting) were measured. Ischemia decreased OXPHOS with TMPD-ascorbate as substrate (electron donor to complex IV via CYTc) and the contents of CYTc and bcl-2. In contrast, AMO preserves OXPHOS, CYTc and bcl-2. Thus, blockade of electron transport preserves bcl-2 content during ischemia with enhanced CYTc retention by SSM. The ETC contributes to mitochondrial damage during ischemia, depleting cardiolipin in the inner membrane and bcl-2 in the outer membrane favoring the two steps required for release of CYTc from mitochondria during ischemia and reperfusion.
Abstract 5014: Increasing Survival to Hospital Following a Myocardial Infarction and Widening Socioeconomic Disparities in Scotland 1986–2005: A Population Study of 5.1 Million People
Authors: Pardeep S Jhund, Kate MacIntyre, James D Lewsey, Adam Redpath, James Chalmers, John J McMurray, Simon Capewell
Journal: Circulation (2008)

Introduction Out of hospital cardiac deaths (OHCD) represent a large and important proportion of total population coronary heart disease mortality. We examined trends in OHCD rates to determine if ...
Irinotecan plus docetaxel in previously treated non-small cell lung cancer (NSCLC): An Alpe Adria Thoracic Oncology Multidisciplinary group phase II study (ATOM 007)
Authors: F. Grossi, O. Belvedere, C. Rossetto, A. Sibau, E. Vigevani, L. Recchia, C. Sacco, A. Iop, S. Tumolo, G. Fasola
Journal: Journal of Clinical Oncology (2004)

7363 Background: Two phase III trials have demonstrated an improvement in survival with docetaxel compared to other single-agents or best supportive care in previously treated NSCLC patients. Still, the combination of docetaxel with another active agent may be feasible and provide further improvement. In vitro studies have demonstrated the synergistic cytotoxicity of irinotecan followed by docetaxel; previous phase I/II studies have assessed the feasibility of this combination in several tumor types. Methods: In this multicenter phase II study, we evaluated the activity and toxicity of irinotecan (160 mg/sqm iv d1) plus docetaxel (65 mg/sqm iv d1) in relapsed or progressing NSCLC patients. Cycles were repeated every 3 weeks up to a maximum of 6 courses. Eligibility criteria: age ≥ 18 yrs; ECOG PS 0–2; measurable disease (RECIST); no prior treatment with irinotecan or docetaxel; adequate hematologic, hepatic and renal function; brain metastases allowed. The impact of treatment on quality of life and tumor-related symptoms was assessed by the EORTC questionnaires QLQ-C30 and LC-13. Results: Thirty-nine patients have been enrolled. Patient characteristics: median age, 61 yrs (46–73); male/female, 29/10; ECOG PS 0/1/2, 13/20/6 patients; adenocarcinoma 36%, squamous cell carcinoma 31%; previous platinum-based treatment, 95%; previous paclitaxel-containing treatment, 46%. One-hundred and sixteen cycles have been given (median 2, range 1–6). Thirty-seven patients are evaluable for toxicity. Grade 3–4 toxicities include 59% neutropenia, 10% anemia, 24% neutropenic fever, 32% diarrhea; 16% nausea/vomiting, 16% fatigue. There has been PR in 3 patients (8%); SD in 11 patients (30%); PD in 13 patients (35%). Median time to progression is 2.7 months; median survival (MST) is 8.4 months. Compliance with quality of life assessment is high (79%). Conclusions: The combination of irinotecan and docetaxel has an acceptable toxicity profile in previously treated NSCLC patients. Although response rate is low, disease stabilization occurred in 30% of patients and an encouraging MST has been observed. No significant financial relationships to disclose.
Abstract 219: Feasibility and Quality of Rapid Standard EEG Testing in Post Cardiac Arrest Patients
Authors: Daniel B Herrick, Manan Hathi, Steven Schulman, Hardin Pantle, Nisha Chandra-Strobos, Sunil Sinha, Michel Torbey, Mary Ann Peberdy, Perry J Foreman, Tori Hysko, Ananth Natarajan, Peter Kaplan, Daniel F Hanley, Romergryko G Geocadin
Journal: Circulation (2010)

Background: The availability of an objective method to assess ongoing neurologic injury, diagnose evolving neuropathology (e.g. seizures), establish prognosis and track neurological status in the e...
Selecting diagnostic tests for evaluation
Authors: Nicholas Summerton
Journal: BMJ (2008)

Walley outlines some of the problems encountered in evaluating laboratory diagnostic tests.1 One of the great difficulties faced by organisations such as the National Institute for Health and Clinical Excellence (NICE) is to find a means to prioritise diagnostic technologies for rapid evaluation. I have recently developed the following prioritisation criteria for use by organisations.

1.  Can the disease be clearly defined? 

2.  Is the condition an important problem …
Conviction by mathematical error?
Authors: S. J Watkins
Journal: BMJ (2000)

<h3>ABSTRACT</h3> With burgeoning human disease genetic associations and single-cell genomic atlases covering a range of tissues, there are unprecedented opportunities to systematically gain insights into the mechanisms of disease-causal variation. However, sparsity and noise, particularly in the context of single-cell epigenomic data, hamper the identification of disease- or trait-relevant cell types, states, and trajectories. To overcome these challenges, we have developed the SCAVENGE method, which maps causal variants to their relevant cellular context at single-cell resolution by employing the strategy of network propagation. We demonstrate how SCAVENGE can help identify key biological mechanisms underlying human genetic variation including enrichment of blood traits at distinct stages of human hematopoiesis, defining monocyte subsets that increase the risk for severe coronavirus disease 2019 (COVID-19), and identifying intermediate lymphocyte developmental states that are critical for predisposition to acute leukemia. Our approach not only provides a framework for enabling variant-to-function insights at single-cell resolution, but also suggests a more general strategy for maximizing the inferences that can be made using single-cell genomic data.
Abstract 10614: Therapeutic Hypothermia: Delay in Reaching Target Temperature Diminishes the Odds of Good Cerebral Performance Post-Cardiac Arrest
Authors: Sue Sendelbach, Mary Hearst, Pamela Jo Johnson, Barbara Unger, Michael Mooney
Journal: Circulation (2011)

Introduction: Initiation of therapeutic hypothermia (TH) post-cardiac arrest has dramatically improved survival. Among survivors, however, anoxic neurologic injury remains an important cause of subsequent mortality and morbidity. There is variability of current TH practice in time to cooling, time to target temperature, and duration of cooling. Thus, we assessed differences in neurologic outcome by time to initiation, time to target temperature, and duration of TH. Methods: We used hospital-specific data from the International Cardiac Arrest Registry (INTCAR) for 172 adult patients with an out-of-hospital cardiac arrest in one Midwestern state. The outcome of interest was Cerebral Performance Category (CPC) classified as good (CPC=1), moderate (CPC=2) or poor (CPC=3-5) neurological outcome. CPC was assessed at transfer from ICU, discharge from hospital, and post discharge follow-up. Multinomial logistic regression models were used to estimate the odds of having a moderate or poor outcome compared with a g...
Abstract 2860: Efficacy and Safety of Vernakalant Hydrochloride Injection for the Treatment of Atrial Fibrillation After Valvular or Coronary Artery Bypass Surgery
Authors: Peter R Kowey, Denis Roy, Craig M Pratt, Peter J Schwartz, Paul Dorian, L B Mitchell, Egon Toft
Journal: Circulation (2007)

Introduction: Postoperative atrial fibrillation (AF) and atrial flutter (AFL) are common after cardiac surgery. This study evaluated the efficacy and safety of vernakalant hydrochloride, a novel atrial selective, frequency- and voltage-dependent Na + and early activating K + channel blocker, in converting AF or AFL to normal sinus rhythm (SR) after coronary artery bypass surgery (CABG), valvular surgery, or both. Methods : This multicenter, double-blind, randomized, placebo-controlled trial included patients aged ≥18 years who had normal SR preceding surgery; had undergone CABG or valvular surgery; and had documented, sustained (3–72 hours) AF or AFL between 24 hours and 7 days after CABG or valvular surgery. Patients were randomly assigned in a 1:2 ratio to receive a 10-min infusion of placebo or vernakalant 3 mg/kg. After 15 min, a second 10-min infusion of placebo or vernakalant 2 mg/kg was given, if AF or AFL persisted. Postdose evaluations included 24-hr Holter monitoring, 12-lead ECG recordings, and assessment of vital signs and AF/AFL symptoms. The primary efficacy measure was conversion to SR for at least 1 minute within 90 min of first exposure. Results : Of 190 patients randomized, 161 received treatment (54 placebo and 107 vernakalant). The main reason for not receiving treatment was spontaneous conversion to SR (7 placebo and 17 vernakalant). Among the patients given treatment, 67% had undergone CABG, 24% had valvular surgery, and 9% had both. The mean age was 68 years, and most patients were men (75%) and white (94%). At entry, 93% of patients had AF, 6% had AFL, and 1% had neither. Conversion to SR within 90 minutes was observed in 45% of patients given vernakalant and 15% of those given placebo ( P = .0002). Of the patients converting to SR with vernakalant, the median time to conversion was 12 minutes and 75% converted on the first dose. In the 24-hr period following study drug administration, adverse events were reported in 32% and 38% of patients given placebo and vernakalant, respectively, of which 2 were serious (complete AV block and hypotension) in the vernakalant group. There were no deaths or cases of torsade de pointes. Conclusions : Vernakalant was effective and well tolerated in the conversion of AF and AFL to SR after CABG, valvular surgery, or both.
Abstract 16164: Total Bilirubin is an Independent Risk Factor for the Prevalence of Coronary Artery Disease in Men
Authors: Anke Nguyen, Heath Adams, Julian Gin, Natalie Yap, Andrew M Wilson
Journal: Circulation (2014)

Introduction: Total bilirubin has been shown to correlate inversely with cardiovascular disease in high risk patients, particularly men. In previous studies, cardiovascular disease has been assessed by cardiovascular events and mortality. Currently there is limited data correlating total bilirubin to angiographic demonstrated coronary artery disease (CAD) in men compared to women. Hypothesis: We assessed the hypothesis that total bilirubin is an independent risk factor for angiographic demonstrated CAD only in men and not in women. Methods: We analysed 565 men and 251 women of the BRAVEHEART cohort presenting for coronary angiography at our institution between October 2009 and March 2014. CAD was defined as the presence of at least 50% stenosis in the left anterior descending artery, left circumflex artery or right coronary artery, as demonstrated on coronary angiography. Multivariate logistic regression was undertaken for each sex to identify independent risk factors for CAD. Results: CAD was present in ...
Anatomy, Physiology, Pathology, Dictionary.
Authors: W. A. Evans, Adolph Gehrmann, William Healy
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Influence of Smoking Status on the Pharmacokinetics and Pharmacodynamics of Clopidogrel and Prasugrel
Authors: Paul A. Gurbel, Kevin P. Bliden, Douglas K. Logan, Dean J. Kereiakes, Kenneth C. Lasseter, Alex White, Dominick J. Angiolillo, Thomas D. Nolin, Jen-Fue Maa, William L. Bailey, Joseph A. Jakubowski, Clement K. Ojeh, Young-Hoon Jeong, Udaya S. Tantry, Brian A. Baker
Journal: Journal of the American College of Cardiology (2013)
Sera from patients with heparin-induced thrombocytopenia generate platelet-derived microparticles with procoagulant activity: an explanation for the thrombotic complications of heparin-induced thrombocytopenia
Authors: TE Warkentin, CP Hayward, LK Boshkov, AV Santos, JA Sheppard, AP Bode, JG Kelton
Journal: Blood (1994)
A Controlled Trial of Casodex™ (Bicalutamide) vs. Flutamide, Each in Combination with Luteinising Hormone-Releasing Hormone Analogue Therapy in Patients with Advanced Prostate Cancer
Authors: M.S. Soloway, P. Schellhammer, R. Sharifi, P. Venner, A.L. Patterson, M. Sarosdy, N. Vogelzang, J. Jones
Journal: European Urology (1996)
Sympathetic Neuropathy Of The Hematopoietic Stem Cell Niche Is Essential For Myeloproliferative Neoplasms
Authors: Lorena Arranz, Abel Sánchez-Aguilera, Joan Isern, Daniel Martín-Pérez, Alexandar Tzankov, Juerg Schwaller, Radek C. Skoda, Simón Méndez-Ferrer
Journal: Blood (2013)
Abstract 13289: Yield of Screening for Coronary Artery Disease in Asymptomatic Male Singapore Armed Forces Employees Using Very Low Radiation Dose Coronary Computed Tomography Angiography
Authors: Yongxian Thng, Jonah Kua, WC Chua, David Foo, Fahim H Jafary
Journal: Circulation (2011)

Background: Screening for coronary artery disease (CAD) among asymptomatic individuals using coronary computed tomography angiography (CTA) is controversial due to concerns about diagnostic yield, therapeutic implications, exposure to radiation and contrast. The Singapore Armed Forces (SAF) instituted a pilot screening program of ‘high risk' individuals using CTA. The aim of this study was to determine the diagnostic yield of a screening program for CAD amongst a selected group of asymptomatic individuals. Method & Results: Men working for the SAF who were over the age of 40 years, had one or more conventional risk factor for CAD and/or abnormalities of the resting ECG were selected for coronary CTA. After baseline renal assessment, these individuals underwent imaging using a 256-slice dual source scanner. Pre-procedure oral beta blockade with atenolol (median dose 50 mg) was used in 93%. A low radiation “flash” protocol was used in 95%. Image quality was acceptable in 98%. A total of 48 SAF employees und...
Mouth Infections and Their Relation to Systemic Diseases: A Review of the Literature.
Authors: Malcolm Graeme MacNevin, Harold Stearns Vaughan
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 10003: Triple Disasters Induced High Incidence of Deep Vein Thrombosis in Fukushima: How Did Mega-Earthquake, Tsunami and Nuclear Plant Accident Affect the Evacuees in Japan?
Authors: Shinya Takase, Hirono Satokawa, Hitoshi Yokoyama
Journal: Circulation (2012)

OBJECTIVES:  Mega-earthquake, tsunami and nuclear power plant accident hit Fukushima, Japan on March 11th, 2011. The tsunami swept away thousands of homes on the shore. In addition, Fukushima-Daiichi nuclear power plant disseminated massive radioactive substances, was forcing thousands of people in the neighborhood to take refuge at remote shelters over 2 months. It is known that post-disaster fatal pulmonary thromboembolism is highly associated with deep vein thrombosis (DVT). We herein report our post-disaster DVT survey and prevention operation for evacuees in Fukushima disaster.  METHODS: From March 28 to May 11 in 2011, ultrasound examination of deep veins below knee was performed on 2,238 evacuees in the shelters by “Advanced Disaster Medical Team of Fukushima Medical University”. The quality of shelter was assessed according to CDC (Centers for Disease Control) shelter assessment tool. The condition of evacuees varied depending on each refugee shelter such as school gym or public facilities. Generally, the utilities such as water, electronic, or gas were cut off during the survey. The food supply was inadequate. The latrines were installed outside of the shelters in the cold environment. Most evacuees slept on the floor mattress.  RESULTS: The overall incidence of DVT was 9.8% (219/2238). Most of the DVTs(94.4%)were identified as chronic and mural in the soleus or gastrocnemius veins. The incidence of DVT at the shelters near Tsunami area was extremely high (35%). The incidence was higher in evacuees from Tsunami area than those from nuclear power plant accident (13.3% vs. 7.5%: P 2 =0.05, P=0.05).   CONCLUSIONS: According to the first experience of triple disaster in human history, high incidence of DVT was demonstrated among more than 2,000 evacuees in Fukushima. The incidence was associated with the cause of evacuation and quality of shelter. Further analysis with long-term follow-up is mandatory for better understanding of post-disaster pathophysiology caused by natural disaster complicated with modern nuclear technology.
Bleeding Complications After Surgical Aortic Valve Replacement Compared With Transcatheter Aortic Valve Replacement
Authors: Philippe Généreux, David J. Cohen, Mathew R. Williams, Michael Mack, Susheel K. Kodali, Lars G. Svensson, Ajay J. Kirtane, Ke Xu, Thomas C. McAndrew, Raj Makkar, Craig R. Smith, Martin B. Leon
Journal: Journal of the American College of Cardiology (2013)