tbuckley/cabot-search huggingface dataset:
Another Cup of Coffee Without an Arrhythmia, Please
Authors: Zachary D. Goldberger, Rodney A. Hayward
Journal: JAMA Internal Medicine (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
MO10-4 The efficacy of pembrolizumab in patients with high-frequency microsatellite instability (MSI-H) solid tumors
Authors: Naotoshi Sugimoto, Akiko Hasegawa, Ryoji Takada, Yutaro Abe, Yugo Kai, Nobuyasu Fukutake, Kenji Ikezawa, Sachiko Yamamoto, Masahiro Watanabe, Tsuyoshi Hisa, Yukinobu Oota, Ikumi Kuno, Tomoyuki Otsuka, Minako Nishio, Toshihiro Kudo, Fumie Fujisawa, Toshinari Yagi, Kazuyoshi Ohkawa, Shoji Kamiura, Fumio Imamura
Journal: Annals of Oncology (2021)
Mental health indicators and lung function following a large oil spill
Authors: Kaitlyn G. Lawrence, Emily J. Werder, Richard K. Kwok, Lawrence S. Engel, Dale P. Sandler
Journal: European Respiratory Journal (2021)

<b>Among GuLF Study participants, findings indicate better lung function associated with severe depression and generalised anxiety, and no association between lung function and PTSD symptoms or perceived stress</b>https://bit.ly/3xpLNRB
P11-7 Efficacy of afatinib following osimertinib in patients with EGFR mutation-positive non-small-cell lung cancer
Authors: Tomohiro Tamura, Hatsumi Okubo, Yutaka Yamada, Yasuko Kikkawa, Shozaburo Yamaguchi, Ikuta Hashimoto, Takayuki Kaburagi
Journal: Annals of Oncology (2021)
Abstract 16325: Patterns of Utilization and Cost of Health Care Among Patients With Chronic Coronary Artery Disease And/Or Peripheral Arterial Disease in Clinical Practice: Analyses of a Large Us Integrated Claims-Emr Database
Authors: Ariel Berger, Qi Zhao, Brian Murphy, Nicholas J Leeper, Windsor Ting, Jeffrey S Berger
Journal: Circulation (2018)

Introduction: “Real-world” use and cost of health care in chronic coronary artery disease (CAD) and/or peripheral arterial disease (PAD) are not well known. Methods: Using Optum© de-identified Inte...
Bilious peritoneal dialysate in a peritoneal dialysis patient
Authors: Winston Wing Shing Fung, Kai Ming Chow, Cheuk Chun Szeto
Journal: Kidney International (2021)

A 71-year-old man on peritoneal dialysis for end-stage kidney disease secondary to hypertensive nephropathy presented with vague right upper quadrant abdominal pain and fever. The initial peritoneal dialysate was mildly cloudy but with a slight brownish hue; he was treated for peritoneal dialysis–related peritonitis with intraperitoneal cefazolin and ceftazidime. However, the peritoneal effluent become dark a few hours after admission (Figure 1). The surgical team was consulted immediately for suspected perforated viscus. An emergency laparotomy confirmed acute gangrenous cholecystitis with perforation. Despite cholecystectomy, the patient deteriorated with septic shock and required high doses of inotrope. He succumbed 2 days after admission. A thorax computed tomography performed for chronic cough a few days before admission showed a distended gallbladder (Figure 2). His blood test showed only mildly raised alkaline phosphatase.Figure 2Computed tomography shows a distended gallbladder with small amount of hyperdense sediment.View Large Image Figure ViewerDownload Hi-res image Download (PPT) Gallbladder perforation is a rare but lethal condition, and its diagnosis is usually difficult and delayed. Typical symptoms include abdominal pain—specifically, in the right upper quadrant—and fever. However, these are nonspecific and similar to other causes of peritonitis. Asymptomatic gallbladder perforation without peritonitis has also been reported previously. Polymicrobial peritonitis are highly suggestive of visceral perforation, but culture results often take days to return. Unusual dialysate color in a patient with acute abdominal pain may be an important early reg flag. Previous work has suggested that ascitic fluid bilirubin levels of >6 mg/dl and ascitic fluid to serum bilirubin ratio of >1 are suggestive of gallbladder perforation. We suggest that the presence of greenish/brownish dialysate, with or without sign of peritonitis, should warrant prompt investigation to exclude gallbladder perforation, which carries a high mortality if recognized late.
The Presence of Recipient CMV Immunodominant Human Leukocyte Antigen (HLA) Alleles Affect Outcomes after Haploidentical (HI) Hematopoietic Stem Cell Transplantation (HSCT)
Authors: Dolores Grosso, Onder Alpdogan, Matthew Carabasi, Joanne Filicko-O'Hara, Sameh Gaballa, Margaret Kasner, Thomas Klumpp, Ubaldo Martinez-Outschoorn, William O'Hara, Neil Palmisiano, John L. Wagner, Pierluigi Porcu, Neal Flomenberg
Journal: Blood (2017)
Mast cell chymase affects the functional properties of primary human airway fibroblasts: Implications for asthma
Authors: Xinran O. Zhao, Maria Lampinen, Ola Rollman, Christian P. Sommerhoff, Aida Paivandy, Gunnar Pejler
Journal: Journal of Allergy and Clinical Immunology (2021)

Mast cells (MCs) have a profound impact on allergic asthma. Under such conditions, MCs undergo degranulation, resulting in the release of exceptionally large amounts of MC-restricted proteases. However, the role of these proteases in asthma is only partially understood.We sought to test our hypothesis that MC proteases can influence the functionality of human lung fibroblasts (HLFs).Primary HLFs were treated with MC chymase or tryptase, followed by assessment of parameters related to fibroblast function.HLFs underwent major morphologic changes in response to chymase, showing signs of cellular contraction, but were refractory to tryptase. However, no effects of chymase on HLF viability or proliferation were seen. Chymase, but not tryptase, had a major impact on the output of extracellular matrix-associated compounds from the HLFs, including degradation of fibronectin and collagen-1, and activation of pro-matrix metalloprotease 2. Further, chymase induced the release of various chemotactic factors from HLFs. In line with this, conditioned medium from chymase-treated HLFs showed chemotactic activity on neutrophils. Transcriptome analysis revealed that chymase induced a proinflammatory gene transcription profile in HLFs, whereas tryptase had minimal effects.Chymase, but not tryptase, has a major impact on the phenotype of primary airway fibroblasts by modifying their output of extracellular matrix components and by inducing a proinflammatory phenotype.
The Fidgety Fetus Hypothesis
Authors: Howard Zisser, Lois Jovanovic, Ashley Thorsell, Asher Kupperman, Larisa J Taylor, Paulina Ospina, Mosha Hod
Journal: Diabetes Care (2006)

OBJECTIVE—To determine whether some offspring of women with diabetes are intrinsically more active than others in utero and whether those who are active are able to normalize their birth weight despite maternal hyperglycemia. RESEARCH DESIGN AND METHODS—We conducted a three-phase study to view the relationship between fetal movements and subsequent birth weight in women with diabetes. Phase I was designed to assess maternal perception of fetal movements in a population of 10 women with diabetes. To improve our fetal monitoring techniques, in phase II we analyzed fetal movements using the Card Guard home fetal monitoring device (CG 900P) in a population of 13 women with gestational diabetes mellitus (GDM). To apply our observations of fetal movements to a larger population, during phase III we conducted a retrospective analysis of fetal monitoring strips (HP 8041A) from 46 women with GDM to examine the relationship between fetal heart rate (FHR) accelerations and percentile birth weight, corrected for gestational age. RESULTS—Phase I confirmed that there is little variability in fetal movements (i.e., fetal kicks did not significantly deviate from one another on a day-to-day basis). In phase II, the fetal monitoring strips illustrated that the active fetuses (defined as ≥4 FHR accelerations in a 20-min period) were always active, and the inactive fetuses were always inactive. The mean birth weight percentile, corrected for gestational age, in the active group was 37 vs. 63% in the inactive group (P = 0.05). In phase III, the fetal monitoring strips showed an inverse correlation between the mean number of FHR accelerations and the birth weight of the fetus, corrected for gestational age. The mean birth weight percentile in the active group was 37 vs. 62% in the inactive group (P = 0.0017). CONCLUSIONS—The fetus appears to play a role in determining its own destiny. Increased fetal activity may minimize the impact of hyperglycemia on subsequent birth weight. The inactive fetus appears to be at a higher risk for glucose-mediated macrosomia.
Microgel assembly: Fabrication, characteristics and application in tissue engineering and regenerative medicine
Authors: Qi Feng, Dingguo Li, Qingtao Li, Xiaodong Cao, Hua Dong
Journal: Bioactive Materials (2021)

Microgel assembly, a macroscopic aggregate formed by bottom-up assembly of microgels, is now emerging as prospective biomaterials for applications in tissue engineering and regenerative medicine (TERM). This mini-review first summarizes the fabrication strategies available for microgel assembly, including chemical reaction, physical reaction, cell-cell interaction and external driving force, then highlights its unique characteristics, such as microporosity, injectability and heterogeneity, and finally itemizes its applications in the fields of cell culture, tissue regeneration and biofabrication, especially 3D printing. The problems to be addressed for further applications of microgel assembly are also discussed.
PD4-1-3 A result of questionnaire about COVID-19 and chemotherapy, for patients utilizing outpatient chemotherapy center
Authors: Takashi Shibata, Yuki Ishimabushi, Masato Suzuki, Toshiki Uchida, Eiji Sakamoto, Tomohiko Ogasawara, Osamu Yamamuro
Journal: Annals of Oncology (2021)
Long-term Outcomes of Laparoscopic Lavage for Perforated Diverticulitis Remain Unfavorable—Reply
Authors: Najia Azhar, Pamela Buchwald, Johannes Kurtz Schultz
Journal: JAMA Surgery (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Relationship between glucosamine use and the risk of lung cancer: data from a nationwide prospective cohort study
Authors: Guowei Li, Xuhui Zhang, Yingxin Liu, Junguo Zhang, Likang Li, Xin Huang, Lehana Thabane, Gregory Y.H. Lip
Journal: European Respiratory Journal (2021)

Research on glucosamine shows anti-inflammatory and anti-cancer benefits with minimal adverse effects. We aimed to explore the relationship between use of glucosamine and risk of lung cancer and lung cancer mortality based on data from the large-scale nationwide prospective UK Biobank cohort study.Participants were enrolled between 2006 and 2010 and followed-up to 2020. The Cox proportional hazards model was used to assess the relationship between glucosamine use and risk of lung cancer and lung cancer mortality. Subgroup analyses and sensitivity analyses were performed to explore the potential effect modifications and the robustness of the main findings.439 393 participants (mean age 56 years; 53% females) with a mean follow-up of 11 years were included for analyses. 82 603 (18.80%) participants reported regular use of glucosamine at baseline. During follow-up, 1971 (0.45%) lung cancer events were documented. Glucosamine use was significantly associated with a decreased risk of lung cancer (hazard ratio (HR) 0.84, 95% CI 0.75-0.92; p<0.001) and lung cancer mortality (HR 0.88, 95% CI 0.81-0.96; p=0.002) in fully adjusted models. A stronger association between glucosamine use and decreased lung cancer risk was observed in participants with a family history of lung cancer when compared with those without a family history.Regular use of glucosamine was significantly related with decreased risk of lung cancer and lung cancer mortality, based on data from this nationwide prospective cohort study.
Abstract 13061: A High-Throughput Phenotype-Based Subtype Classification of Long-QT Syndrome Using Induced Pluripotent Stem Cell Model
Authors: Daisuke Yoshinaga, Shiro Baba, Takeru Makiyama, Hirofumi Shibata, Takuya Hirata, Hirohiko Kohjitani, Yimin Wuriyanghai, Yuta Yamamoto, Bruce Conklin, Minoru Horie, Junko Takita, Toshio Heike
Journal: Circulation (2019)

Introduction: For long-QT syndrome (LQTS), recent progress in genome-sequencing technologies enabled the identification of rare genomic variants with diagnostic, prognostic, and therapeutic implica...
Polyethylene glycol-based linkers as hydrophilicity reservoir for antibody-drug conjugates
Authors: T. Tedeschini, B. Campara, A. Grigoletto, M. Bellini, M. Salvalaio, Y. Matsuno, A. Suzuki, H. Yoshioka, G. Pasut
Journal: Journal of Controlled Release (2021)

Antibody-drug conjugates (ADCs) are an established therapeutic entity in which potent cytotoxic drugs are conjugated to a monoclonal antibody. In parallel with the great emphasis put on novel site-specific bioconjugation technologies, future advancements in this field also rely on exploring novel linker-drug architectures that improve the efficacy and stability of ADCs. In this context, the use of hydrophilic linkers represents a valid strategy to mask or reduce the inherent hydrophobicity of the most used cytotoxic drugs and positively impact the physical stability and in vivo performance of ADCs. Here, we describe the use of linkers containing monodisperse poly(ethylene glycol) (PEG) moieties for the construction of highly-loaded lysine-conjugated ADCs. The studied ADCs differ in the positioning of PEG (linear or pendant), the bonding type with the antibody (amide or carbamate), and the drug-to-antibody ratio (DAR). These ADCs were first evaluated for their stability in solution under thermal stress, showing that both the drug-linker-polymer design and the nature of the antibody-linker bonding are of great importance for their physical and chemical stability. Amide-coupled ADCs bearing two pendant 12-unit poly(ethylene glycol) chains within the drug-linker structure were the best performing conjugates, distancing themselves from the ADCs obtained with a conventional linear 24-unit PEG oligomer or the linker of Kadcyla®. The pharmacokinetic profiles of amide-linked ADCs, with a linear or pendant configuration of the PEG, were tested in mice in comparison to Kadcyla®. Total antibody pharmacokinetics paralleled the trends in aggregation tendency, with slower clearance rates for the ADCs based on the pendant drug-linker format. The above-mentioned findings have provided important clues on the drug-linker design and revealed that the positioning and configuration of a PEG unit have to be carefully tuned to achieve ADCs with improved stability and pharmacokinetics.
Disease burden, symptoms, and use of analgesics in patients with psoriasis with or without psoriatic arthritis: A cross-sectional study
Authors: Nikolai Loft, Thao Thi Nguyen, Lars Erik Kristensen, Jacob P. Thyssen, Alexander Egeberg
Journal: Journal of the American Academy of Dermatology (2021)

Patients with psoriasis have an impaired quality of life and higher use of analgesics than the general population. Whether such use is due to skin pain or a consequence of joint pain resulting from psoriatic arthritis (PsA) is not clear.To assess symptoms, disease burden, and use of analgesics in patients with psoriasis with and without PsA.Symptoms, general health (EurQol 5-dimension and 5-levels), and use of analgesics were assessed in patients with psoriasis and the general population from the Danish Skin Cohort.We included 4016 patients with psoriasis (847 with concomitant PsA) and 3490 reference individuals. For patients with psoriasis having PsA, itch, skin pain, and/or joint pain was associated with worse general health. Use of opioids within 12 months was observed among 9.0% of the general population, 14.2% of patients with psoriasis without PsA, and 22.7% of patients with concomitant PsA. Of the symptoms, only joint pain was associated with use of analgesics (odds ratio, 3.72 (2.69-5.14); P < .0001).Cross-sectional design.Patients with psoriasis (especially concomitant PsA) have a higher use of analgesics compared with the general population, which appears to be a result of increased joint pain.
Temporal change in population-level prevalence of detectable HIV viraemia and its association with HIV incidence in key populations in India: a serial cross-sectional study
Authors: Eshan U Patel, Sunil S Solomon, Gregory M Lucas, Allison M McFall, Aylur K Srikrishnan, Muniratnam S Kumar, Syed H Iqbal, Shanmugam Saravanan, Nandagopal Paneerselvam, Pachamuthu Balakrishnan, Oliver Laeyendecker, David D Celentano, Shruti H Mehta
Journal: The Lancet HIV (2021)
IL‐1β‐Induced Elevation of Solute Carrier Family 7 Member 11 Promotes Hepatocellular Carcinoma Metastasis Through Up‐regulating Programmed Death Ligand 1 and Colony‐Stimulating Factor 1
Authors: Qin He, Mei Liu, Wenjie Huang, Xiaoping Chen, Bixiang Zhang, Tongyue Zhang, Yijun Wang, Danfei Liu, Meng Xie, Xiaoyu Ji, Mengyu Sun, Dean Tian, Limin Xia
Journal: Hepatology (2021)

Background and Aims Because of a paucity of effective treatment options, metastasis is still a major cause for HCC-associated mortality. The molecular mechanism of inflammation-induced HCC metastasis is open for study. Here, we characterized the function of solute carrier family 7 member 11 (SLC7A11) in inflammation-related HCC metastasis and probed therapy strategies for this subpopulation of patients. Approach and Results Elevated expression of SLC7A11 was positively correlated with poor tumor differentiation, and higher tumor-nodule-metastasis stage, and indicated poor prognosis in human HCC. SLC7A11 increased HIF1α expression through reducing α-ketoglutarate (αKG) level by exporting glutamate. SLC7A11 up-regulated programmed death ligand 1 (PD-L1) and colony-stimulating factor 1 (CSF1) expression through αKG-HIF1α cascade. SLC7A11 overexpression in HCC cells promoted intratumoral tumor-associated macrophage (TAM) and myeloid­derived suppressor cell (MDSC) infiltration through the CSF1/colony-stimulating factor 1 receptor (CSF1R) axis, whereas knockdown of CSF1 attenuated SLC7A11-mediated intratumoral TAM and MDSC infiltration and HCC metastasis. Depletion of either TAMs or MDSCs decreased SLC7A11-mediated HCC metastasis. Furthermore, the combination of CSF1R inhibitor BZL945 and anti-PD-L1 antibody blocked SLC7A11-induced HCC metastasis. In addition, IL-1β up-regulated SLC7A11 expression through the interleukin-1 receptor type 1 (IL-1R1)/extracellular signal-regulated kinase/specificity protein 1 pathway. SLC7A11 knockdown impaired IL-1β-promoted HCC metastasis. Anakinra, an IL-1R1 antagonist, reversed IL-1β-promoted HCC metastasis. In human HCC tissues, SLC7A11 expression was positively associated with HIF1α, PD-L1, and CSF1 expression and intratumoral TAM and MDSC infiltration. Conclusions IL-1β-induced SLC7A11 overexpression up-regulated PD-L1 and CSF1 through the αKG/HIF1α axis, which promoted TAM and MDSC infiltration. Interruption of this oncogenic loop may provide a promising therapy strategy for the inhibition of SLC7A11-mediated HCC metastasis.
EXTH-15. MULTI-FACETED INHIBITION OF TET PATHWAY WITH CELL-PERMEABLE 2HG AND BOBCAT 339 REDUCES PROLIFERATION AND INDUCES APOPTOSIS IN DIPG
Authors: Akhila Parthasarathy, Antje Arnold, Charles Eberhart, Eric Raabe
Journal: Neuro-Oncology (2021)

Abstract Diffuse Intrinsic Pontine Glioma (DIPG) is one of the worst forms of pediatric brain tumors, with a 100% mortality-rate. A prominent mutation observed in them is a lysine to methionine change in histone3 which causes trapping of the repressive-chromatin-complex, leading to genome-level hypomethylation, affecting global epigenetic-regulation. Ten-Eleven Translocation (TET) proteins are alpha-ketoglutarate (α-KG) dependent dioxygenases that mediate the conversion of 5-methylcytosine to 5-hydroxymethylcytosine (5hmC), a key-step in removing DNA methylation-marks. We previously identified increased levels of 5hmC and TETs in DIPG. In IDH mutant glioma, the R132H-IDH produces an oncometabolite, 2-hydroxyglutarate (2HG), instead of α-KG. 2HG competitively inhibits TET function, resulting in a hypermethylated genome. Bobcat339, a cytosine-analog targets TETs by blocking the cytosine binding-site on TETs. We hypothesized that cell-permeable 2HG and Bobcat339 would synergize to block TET activity in DIPG, restore epigenetic-balance by increasing genomic methylation, and induce cell-death. 2HG induced apoptosis in DIPG cells at concentrations ranging from 100-300uM, as measured by cleaved-PARP western and cleaved-caspase3 immunofluorescence (2-7fold increase in CC3, depending on cell line). Cell-permeable 2HG also decreased proliferation, measured by phospho-RB western in DIPG cells (30-50% reduction in pRB band intensity, depending on cell line). Similarly, Bobcat339 suppressed proliferation at concentrations from 10-50uM, measured by BrdU incorporation (25% reduction in BrdU+ at 50uM, p= 0.02 compared to control). Bobcat339 induced apoptosis, measured by cPARP western and CC3 immunofluorescence (4-10fold more of CC3+ compared to control p&amp;lt; 0.0004). In combination, cell-permeable 2HG (100-200uM) and Bobcat339 (10-20uM) combined to suppress cell-viability, measured by CellTiterBlue assay, producing ZIP scores of ~20 in DIPG cells (indicating high-level synergy). In combination, 2HG and Bobcat339 increased apoptosis in DIPG (3-fold increase in cleaved-PARP band intensity in JHH-DIPG1 cells treated with 20uM Bobcat339 + 100uM 2HG, compared to single-treated cells). Our results may lead to new approaches that target TET pathway in DIPG tumors.