tbuckley/cabot-search huggingface dataset:
Comment on Powers et al. Diabetes Self-management Education and Support in Type 2 Diabetes: A Joint Position Statement of the American Diabetes Association, the American Association of Diabetes Educators, and the Academy of Nutrition and Dietetics. Diabetes Care 2015;38:1372–1382
Authors: Shara R. Bialo, Jonny White, Wendy Satin Rapaport
Journal: Diabetes Care (2015)

The recently published joint position statement authored by Powers et al. (1) defines when, what, and how diabetes self-management education and support should be provided for adults with type 2 diabetes, with aims to improve patient experience and care and to reduce diabetes-associated health care costs. We applaud the position statement’s emphasis on mental health assessment as a core component of diabetes care but are concerned and disappointed that referral to a mental health professional is recommended only on an “if needed” basis in their algorithm of care. Mental health care warrants equal priority in the interdisciplinary care of patients with diabetes, and we believe the American Diabetes Association (ADA) …
77P Dual targeting oxidative phosphorylation and glycolysis in triple-negative breast cancers: En route to effective inhibition of tumour metabolism
Authors: A.M. Scherbakov, O. Omelchuk, D. Sorokin, V. Shatskaya, A. Shchekotikhin, M. Krasil’nikov
Journal: Annals of Oncology (2020)
Risk of a post-colonoscopy colorectal cancer diagnosis in patients with inflammatory bowel disease: a population-based cohort study
Authors: Frederikke Schønfeldt Troelsen, Henrik Toft Sørensen, Lars Pedersen, Rune Erichsen
Journal: Endoscopy (2020)

Abstract Background Post-colonoscopy colorectal cancers (PCCRCs) may account for up to 50 % of all colorectal cancers (CRCs) diagnosed in patients with inflammatory bowel disease (IBD). This may reflect a high colonoscopy frequency; however, evidence remains limited. Methods We conducted a cohort study of IBD and non-IBD patients undergoing colonoscopy. We calculated cumulative incidence proportions (CIPs) of PCCRC at 7–36 months after first-time and subsequent colonoscopies. We also computed crude and adjusted hazard ratios (HRs) of PCCRC, comparing IBD with non-IBD patients undergoing first-time and subsequent colonoscopies. Separate analyses were conducted for consecutive colonoscopies. We calculated 3-year rates of PCCRC to estimate the proportion of IBD and non-IBD CRC patients experiencing PCCRC. Results We observed 138 and 1909 PCCRCs among 34 688 IBD and 358 217 non-IBD patients who underwent colonoscopy. The CIP of PCCRC after first-time colonoscopy was 0.21 % (95 % confidence interval [CI] 0.17 %–0.27 %) for IBD patients and 0.37 % (95 %CI 0.35 %–0.39 %) for non-IBD patients. The adjusted HR of PCCRC after a first-time colonoscopy was 0.96 (95 %CI 0.75–1.22) and the adjusted HRs after subsequent colonoscopies had point estimates around 1.0. The 3-year PCCRC rate was 24.3 % (95 %CI 20.4 %–28.7 %) for IBD and 7.5 % (95 %CI 7.2 %–7.8 %) for non-IBD patients. Conclusions Although PCCRCs accounted for a substantial proportion of all IBD-related CRCs, IBD patients had a low CIP of PCCRC. The elevated 3-year PCCRC rates may, among other factors, stem from the increased colonoscopy frequency in IBD patients.
Alpha 1-antichymotrypsin contributes to stem cell characteristics and enhances tumorigenicity of glioblastoma
Authors: Montserrat Lara-Velazquez, Natanael Zarco, Anna Carrano, Jordan Phillipps, Emily S Norton, Paula Schiapparelli, Rawan Al-kharboosh, Jordina Rincon-Torroella, Stephanie Jeanneret, Teresa Corona, Jose Segovia, Mark E Jentoft, Kaisorn L Chaichana, Yan W Asmann, Alfredo Quiñones-Hinojosa, Hugo Guerrero-Cazares
Journal: Neuro-Oncology (2020)

Abstract Background Glioblastomas (GBMs) are the main primary brain tumors in adults with almost 100% recurrence rate. Patients with lateral ventricle proximal GBMs (LV-GBMs) exhibit worse survival compared to distal locations for unknown reasons. One hypothesis is the proximity of these tumors to the cerebrospinal fluid (CSF) and its chemical cues that can regulate cellular phenotype. We therefore investigated the role of CSF on GBM gene expression and the role of a CSF-induced gene, SERPINA3, in GBM malignancy in vitro and in vivo. Methods We utilized human CSF and GBM brain tumor-initiating cells (BTICs). We determined the impact of SERPINA3 expression in glioma patients using The Cancer Genome Atlas (TCGA) database. SERPINA3 expression changes were evaluated at mRNA and protein levels. The effects of knockdown (KD) and overexpression (OE) of SERPINA3 on cell migration, viability and cell proliferation were evaluated. Stem cell characteristics on KD cells were evaluated by differentiation and colony formation experiments. Tumor growth was studied by intracranial and flank injections. Results GBM-CSF increased BTIC migration accompanied by upregulation of the SERPINA3 gene. In patient samples and TCGA data, we observed SERPINA3 to correlate directly with brain tumor grade and indirectly with GBM patient survival. SERPINA3 KD induced a decrease in cell proliferation, migration, invasion, and stem cell characteristics, while SERPINA3 OE increased cell migration. In vivo, SERPINA3 KD BTICs showed increased survival in a murine model. Conclusions SERPINA3 plays a key role in GBM malignancy and its inhibition results in a better outcome using GBM preclinical models.
145P A nomogram for predicting the benefit of adjuvant chemotherapy after resection in patients with Borrmann type IV gastric cancer
Authors: Q-Z. Qiu, F-H. Wang, Y-H. Tang, C-H. Zheng, P. Li, J-W. Xie, J-B. Wang, J-X. Lin, J. Lu, Q-Y. Chen, L-L. Cao, M. Lin, R-H. Tu, Z-N. Huang, J-L. Lin, H-L. Zheng, C. Huang
Journal: Annals of Oncology (2020)
Intracystic Papillary Neoplasm of Gallbladder Mimicking Metastatic Malignancy on PET/CT
Authors: Rasha Ismail, Anas Saeed Bamashmos, Paul J. Cohen, Darko Pucar
Journal: Clinical Nuclear Medicine (2020)

Abstract Intracystic papillary neoplasm of the gallbladder is a rare preinvasive neoplastic lesion with similar characteristics as intraductal papillary mucinous neoplasm and other papillary neoplasms of pancreaticobiliary system. We report a case of 48-year-old woman with a history of recurrent right flank chondrosarcoma and gallbladder lesion on MRI and PET/CT interpreted as indeterminate for metastatic disease. Subsequent cholecystectomy showed intracystic papillary neoplasm. With gallbladder lesions being rare on PET/CT, this case illustrates the importance of considering both primary and secondary tumors in the differential diagnosis.
Delayed 68Ga-PSMA PET/CT Image-Guided Biopsy for Low-Grade Adenocarcinoma in Benign Prostatic Hyperplasia
Authors: Sampath Santhosh, Godwin Jeeva
Journal: Clinical Nuclear Medicine (2020)

Abstract Image-guided biopsy of prostate with multiparametric MRI is being adopted in the workup of prostate adenocarcinoma (PAC). 68 Ga-PSMA PET/CT-guided biopsy has also been shown to be equally sensitive in the evaluation of higher-grade tumors with increased PSMA expression. The sensitivity of 68 Ga-PSMA PET/CT, however, reduces with lesser PSMA expression in low-grade PAC. Herein, we demonstrate a case where delayed 68 Ga-PSMA PET/CT imaging helped in detecting low-grade PAC in BPH.
128P Clinical update with plasma and tumour-based genomic analyses in expansion part of phase I study of selective FGFR inhibitor E7090
Authors: C. Morizane, M. Ueno, T. Ioka, M. Tajika, M. Ikeda, K. Yamaguchi, H. Hara, H. Yabusaki, A. Miyamoto, S. Iwasa, M. Muto, T. Takashima, K. Minashi, Y. Komatsu, T. Nishina, T. Nakajima, T. Sahara, S. Funasaka, M. Yashiro, J. Furuse
Journal: Annals of Oncology (2020)
2020 ACC Expert Consensus Decision Pathway for Anticoagulant and Antiplatelet Therapy in Patients With Atrial Fibrillation or Venous Thromboembolism Undergoing Percutaneous Coronary Intervention or With Atherosclerotic Cardiovascular Disease
Authors: Dharam J. Kumbhani, Christopher P. Cannon, Craig J. Beavers, Deepak L. Bhatt, Adam Cuker, Ty J. Gluckman, Joseph E. Marine, Roxana Mehran, Steven R. Messe, Nimesh S. Patel, Benjamin E. Peterson, Kenneth Rosenfield, Sarah A. Spinler, Vinod H. Thourani
Journal: Journal of the American College of Cardiology (2020)
CMR in Myocarditis: Valuable Tool, Room for Improvement⁎⁎Editorials published in JACC: Cardiovascular Imaging reflect the views of the authors and do not necessarily represent the views of JACC: Cardiovascular Imaging or the American College of Cardiology.
Authors: Godtfred Holmvang, G. William Dec
Journal: JACC. Cardiovascular imaging (2012)
Negative Conversion Rate of SARS-CoV-2 Infection—Reply
Authors: Seungjae Lee, Tark Kim, Eunjung Lee
Journal: JAMA Internal Medicine (2020)

Seungjae Lee, MD; Tark Kim, MD; Eunjung Lee, MD; Cheolgu Lee, MD; Hojung Kim, MD; Heejeong Rhee, MD; Se Yoon Park, MD; Hyo-Ju Son, MD; Shinae Yu, MD; Jung Wan Park, MD; Eun Ju Choo, MD; Suyeon Park, MS; Mark Loeb, MD; Tae Hyong Kim, MD
Longitudinal Strain Imaging in Light-Chain Cardiac Amyloidosis: Can it Help to Refine the Approach to Treatment?⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Authors: C. Cristina Quarta, Rodney H. Falk
Journal: Journal of the American College of Cardiology (2012)
SAT0636 A DRUG INDUCED REMISSION SIGNATURE PROMISES PERSONALIZED THERAPY IN RA PATIENTS
Authors: Madah Mehdi, Sabrina Danilin, Matthieu Coq, Hüseyin Firat, Florence Apparailly, Yves-Marie Pers, Christian Jorgensen
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background:</h3> Today the objective for efficient Rheumatoid Arthritis (RA) therapy is not restricted to reduced synovial inflammation but to induce immunological and clinicaly lasting remission. Despite improvement in therapy of RA, anti-TNF alpha or anti-IL-6 (Tocilizumab) biologicals provide less than 20% of clinical remission. Interestingly, the complete remission can last up to 12 months in about 40% of these patients despite discontinuation of the above biologicals. In order to set up optimized strategy to obtain persistent clinical remission, new predictive markers of complete remission are needed. <h3>Objectives:</h3> By using Firalis' BIOPRED panel, an innovative targeted gene sequencing panel of 2155 mRNA targets associated with immune-inflammatory pathways, we identified candidate biomarkers that have the potential to stratify patients for personalized therapy. <h3>Methods:</h3> Paxgene RNA samples obtained from 18 RA patients treated with Etanercept (n=11) and Tocilizumab (n=7) who had achieved remission (DAS28 &lt; 2.6) were directly profiled without RNA extraction with BIOPRED panel, a targeted sequencing kit based on HTG EdgeSeq platform. Data were extracted using HTG Parser software and normalized using EdgeR method. Student T-test was applied to find out targets which are significantly regulated. <h3>Results:</h3> In total, 37 mRNA targets are found to be significantly up- or down-regulated in Etanercept groups as compared to Tocilizumab group (p-value &lt;0.05). 3 mRNA genes are found to be significantly upregulated with fold change of &gt; 2 (p-value &lt; 0.05) and 1 mRNA gene is found to be significantly downregulated with fold change of &lt;0.5 (p-value &lt; 0.05). <h3>Conclusion:</h3> Our preliminary analysis shows that a panel of candidate predictive markers for biological specific (Etanercept) remission has the potential to stratify patients for personalized therapy in RA patients. Longitudinal studies are required with RA patients treated with all biologicals to validate this signature and explore further dimensions. <h3> Disclosure of Interests:</h3> None declared
189P Prognostic value of inflammation-based score for patients treated with FOLFIRINOX (FFX) or gemcitabine plus nab-paclitaxel (GnP)
Authors: T. Yamamura, S. Nakano, R. Saito, K. Ito, H. Nakatsumi, K. Harada, Y. Kawamoto, S. Yuki, N. Sakamoto, Y. Komatsu
Journal: Annals of Oncology (2020)
15340 Long-term treatment with secukinumab led to sustained clinical improvement and normalization of inflammatory markers in patients with psoriasis
Authors: James G. Krueger, David Pariser, Stephen K. Tyring, Jerry Bagel, Andrew F. Alexis, Jennifer Soung, April W. Armstrong, Elisa Muscianisi, Farid Kianifard, Mr. Rajendra Prasad Sarkar, Andrew Blauvelt
Journal: Journal of the American Academy of Dermatology (2020)
Proprotein Convertase Subtilisin/Kexin Type 9 as Transducer of Physiologic Influences on Cellular Cholesterol: A Case for Resistin⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Authors: Sergio Fazio, MacRae F. Linton
Journal: Journal of the American College of Cardiology (2012)
Abstract 15315: Clinical Risk Factors for Onset of Atrial Fibrillation Early After Acute Myocardial Infarction
Authors: Katsuomi Iwakura, Atsunori Okamura, Yasushi Koyama, Koichi Inoue, Mutsumi Iwamoto, Hiroyuki Nagai, Yuko Toyoshima, Koji Tanaka, Takafumi Oka, Kenshi Fujii
Journal: Circulation (2016)

Introduction: Atrial fibrillation (AF) occurring early after acute myocardial infarction (AMI) is as an independent predictor of adverse short- and long-term outcomes. Risk factors for AF include a...
236O Olaparib (ola) plus bevacizumab (bev) as maintenance (mx) therapy in patients (pts) with newly diagnosed advanced ovarian carcinoma (OC): Japan subset of the PAOLA-1 trial
Authors: K. Fujiwara, H. Fujiwara, H. Yoshida, T. Satoh, K. Yonemori, S. Nagao, T. Matsumoto, H. Kobayashi, H. Bourgeois, P. Harter, A.M. Mosconi, I. Palacio, A. Reinthaller, T. Fujita, R. Bloomfield, E. Pujade-Lauraine, I.L. Ray-Coquard
Journal: Annals of Oncology (2020)
114O Assessment of robotic versus laparoscopic distal gastrectomy for gastric cancer: A randomized controlled trial
Authors: J. Lu, D. Wu, H-G. Wang, C-H. Zheng, P. Li, J-W. Xie, J-B. Wang, J-X. Lin, Q-Y. Chen, L-L. Cao, M. Lin, R-H. Tu, Z-N. Huang, J-L. Lin, H-L. Zheng, C. Huang
Journal: Annals of Oncology (2020)
A natural <i>DNMT1</i> mutation elevates the fetal hemoglobin level via epigenetic derepression of the γ-globin gene in β-thalassemia
Authors: Yi Gong, Xinhua Zhang, Qianqian Zhang, Yanxia Zhang, Yuhua Ye, Wenxia Yu, Congwen Shao, Tizhen Yan, Jin Huang, Jianmei Zhong, Li Wang, Yaoyun Li, Liren Wang, Xiangmin Xu
Journal: Blood (2020)
2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy
Authors: Steve R. Ommen, Seema Mital, Michael A. Burke, Sharlene M. Day, Anita Deswal, Perry Elliott, Lauren L. Evanovich, Judy Hung, José A. Joglar, Paul Kantor, Carey Kimmelstiel, Michelle Kittleson, Mark S. Link, Martin S. Maron, Matthew W. Martinez, Christina Y. Miyake, Hartzell V. Schaff, Christopher Semsarian, Paul Sorajja
Journal: Circulation (2020)
Safety and clinical efficacy of BCMA CAR-T-cell therapy in multiple myeloma
Authors: Gils Roex, Marijke Timmers, Kristien Wouters, Diana Campillo-Davo, Donovan Flumens, Wilfried Schroyens, Yiwei Chu, Zwi N. Berneman, Eva Lion, Feifei Luo, Sébastien Anguille
Journal: Journal of Hematology & Oncology (2020)

Abstract Background B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor (CAR)-T-cell therapy is an emerging treatment option for multiple myeloma. The aim of this systematic review and meta-analysis was to determine its safety and clinical activity and to identify factors influencing these outcomes. Methods We performed a database search using the terms “BCMA,” “CAR,” and “multiple myeloma” for clinical studies published between 01/01/2015 and 01/01/2020. The methodology is further detailed in PROSPERO (CRD42020125332). Results Twenty-three different CAR-T-cell products have been used so far in 640 patients. Cytokine release syndrome was observed in 80.3% (69.0–88.2); 10.5% (6.8–16.0) had neurotoxicity. A higher neurotoxicity rate was reported in studies that included more heavily pretreated patients: 19.1% (13.3–26.7; I 2 = 45%) versus 2.8% (1.3–6.1; I 2 = 0%) ( p &lt; 0.0001). The pooled overall response rate was 80.5% (73.5–85.9); complete responses (CR) were observed in 44.8% (35.3–54.6). A pooled CR rate of 71.9% (62.8–79.6; I 2 = 0%) was noted in studies using alpaca/llama-based constructs, whereas it was only 18.0% (6.5–41.1; I 2 = 67%) in studies that used retroviral vectors for CAR transduction. Median progression-free survival (PFS) was 12.2 (11.4–17.4) months, which compared favorably to the expected PFS of 1.9 (1.5–3.7) months (HR 0.14; p &lt; 0.0001). Conclusions Although considerable toxicity was observed, BCMA-targeted CAR-T-cell therapy is highly efficacious even in advanced multiple myeloma. Subgroup analysis confirmed the anticipated inter-study heterogeneity and identified potential factors contributing to safety and efficacy. The results of this meta-analysis may assist the future design of CAR-T-cell studies and lead to optimized BCMA CAR-T-cell products.
KRAS-regulated glutamine metabolism requires UCP2-mediated aspartate transport to support pancreatic cancer growth
Authors: Susanna Raho, Loredana Capobianco, Rocco Malivindi, Angelo Vozza, Carmela Piazzolla, Francesco De Leonardis, Ruggiero Gorgoglione, Pasquale Scarcia, Francesca Pezzuto, Gennaro Agrimi, Simona N. Barile, Isabella Pisano, Stephan J. Reshkin, Maria R. Greco, Rosa A. Cardone, Vittoria Rago, Yuan Li, Carlo M. T. Marobbio, Wolfgang Sommergruber, Christopher L. Riley, Francesco M. Lasorsa, Edward Mills, Maria C. Vegliante, Giuseppe E. De Benedetto, Deborah Fratantonio, Luigi Palmieri, Vincenza Dolce, Giuseppe Fiermonte
Journal: Nature Metabolism (2020)
The Impact of Murmur’s Severity on the Cardiac Variability
Authors: S.M Debbal, F. Mokeddem, F. Meziani, L.Hamza Cherif
Journal: Clinical Cardiology and Cardiovascular Interventions (2020)

Phonocardiogram (PCG) signal is one of the useful approach to explore cardiac activity, and extract many features to help researchers to develop technic that may serve medical stuff to the diagnosis of several cardiac diseases. For people when it comes to a heart activity problem it is a serious health matter that need special care. In this paper, the importance is given to heart murmurs to highlight their impact. Heart murmurs are very common disease in world and depend on their severity they could be life-threatening point; therefore, the purpose of this paper is focused on three essential steps: first is to design an algorithm to extract only heart murmurs from a pathological phonocardiogram signal (PCG) as a basic background to the whole work. Than calculate their severity based on energy ratio (ER) which is recommended by recent studies as an effective factor, in order to classify them to mild, medium and severe murmurs. In other hand, this classification will served to study the impact of severity of systolic and diastolic murmurs on cardiac variability, which is very important indicator on general health of human body. This study is done on consider number of patients and its reveal on very interesting results.
Proportion of Idiopathic Pulmonary Fibrosis Risk Explained by Known Common Genetic Loci in European Populations
Authors: Olivia C. Leavy, Shwu-Fan Ma, Philip L. Molyneaux, Toby M. Maher, Justin M. Oldham, Carlos Flores, Imre Noth, R. Gisli Jenkins, Frank Dudbridge, Louise V. Wain, Richard J. Allen
Journal: American Journal of Respiratory and Critical Care Medicine (2020)
No evidence of SARS-CoV-2 circulation in HIV-infected patients between December 2019 and February 2020 in Rome, Italy
Authors: Francesca Lombardi, Simone Belmonti, Rosalba Ricci, Alberto Borghetti, Massimiliano Fabbiani, Arturo Ciccullo, Roberto Cauda, Simona Di Giambenedetto
Journal: Clinical Microbiology and Infection (2020)
Human milk oligosaccharide DSLNT and gut microbiome in preterm infants predicts necrotising enterocolitis
Authors: Andrea C Masi, Nicholas D Embleton, Christopher A Lamb, Gregory Young, Claire L Granger, Julia Najera, Daniel P Smith, Kristi L Hoffman, Joseph F Petrosino, Lars Bode, Janet E Berrington, Christopher J Stewart
Journal: Gut (2020)

Objective Necrotising enterocolitis (NEC) is a devastating intestinal disease primarily affecting preterm infants. The underlying mechanisms are poorly understood: mother’s own breast milk (MOM) is protective, possibly relating to human milk oligosaccharide (HMO) and infant gut microbiome interplay. We investigated the interaction between HMO profiles and infant gut microbiome development and its association with NEC. Design We performed HMO profiling of MOM in a large cohort of infants with NEC (n=33) with matched controls (n=37). In a subset of 48 infants (14 with NEC), we also performed longitudinal metagenomic sequencing of infant stool (n=644). Results Concentration of a single HMO, disialyllacto-N-tetraose (DSLNT), was significantly lower in MOM received by infants with NEC compared with controls. A MOM threshold level of 241 nmol/mL had a sensitivity and specificity of 0.9 for NEC. Metagenomic sequencing before NEC onset showed significantly lower relative abundance of Bifidobacterium longum and higher relative abundance of Enterobacter cloacae in infants with NEC. Longitudinal development of the microbiome was also impacted by low MOM DSLNT associated with reduced transition into preterm gut community types dominated by Bifidobacterium spp and typically observed in older infants. Random forest analysis combining HMO and metagenome data before disease accurately classified 87.5% of infants as healthy or having NEC. Conclusion These results demonstrate the importance of HMOs and gut microbiome in preterm infant health and disease. The findings offer potential targets for biomarker development, disease risk stratification and novel avenues for supplements that may prevent life-threatening disease.
Wrinkles in the Atrium: Age, Atrial Fibrillation, or Something Else⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Authors: Samuel J. Asirvatham, Joseph J. Gard
Journal: Journal of the American College of Cardiology (2011)
Cardiac Resynchronization Therapy: The More Pacing Sites, the Better the Outcome?⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Authors: Angelo Auricchio, Frits W. Prinzen
Journal: Journal of the American College of Cardiology (2008)
13509 Integrated safety analysis of FMX103 1.5% topical minocycline foam for the treatment of moderate to severe papulopustular rosacea: Results from two phase 3 studies
Authors: Linda Stein Gold, James Q. Del Rosso, Leon Kircik, Neal Bhatia, Deirdre Hooper, Walter K. Nahm
Journal: Journal of the American Academy of Dermatology (2020)
Diffuse Subcutaneous Metabolic Activity in Post Bone Marrow Transplant Hodgkin Lymphoma
Authors: Abtin Doroudinia, Payam Mehrian, Alireza Rouhizadeh, Mahsa Hosseini
Journal: Clinical Nuclear Medicine (2020)

Abstract We present a 14-year-old adolescent boy with Hodgkin lymphoma. He had prior completed chemotherapy with ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) regimen followed by bone marrow transplantation 6 months ago. Currently, he has neither specific clinical complaint nor receiving any specific medication. Follow-up FDG PET/CT scan demonstrated diffuse increased metabolic activity in the entire body subcutaneous tissue. This finding is rarely reported in the literature and may represent an underlying active inflammatory process, most likely attributed to the received treatments. This could impair the diagnostic quality of the scan, affecting the image interpretation, and should be recognized when present.
Cantharidin Drug-Device Clears Molluscum Contagiosum Lesions
Authors: Anita Slomski
Journal: JAMA (2020)

A drug-device containing the topical vesicant cantharidin safely and effectively treated molluscum contagiosum in 2 identical phase 3 multicenter US trials published in JAMA Dermatology. The common viral skin infection can last for years and has no approved treatment.