tbuckley/cabot-search huggingface dataset:
Biocompatible Iron–Boron Nanoparticles Designed for Neutron Capture Therapy Guided by Magnetic Resonance Imaging
Authors: Veronica Torresan, Andrea Guadagnini, Denis Badocco, Paolo Pastore, Guillermo Arturo Muñoz Medina, Marcela B. Fernàndez van Raap, Ian Postuma, Silva Bortolussi, Marina Bekić, Miodrag Čolić, Marco Gerosa, Alice Busato, Pasquina Marzola, Vincenzo Amendola
Journal: Advanced Healthcare Materials (2020)

Abstract The combination of multiple functions in a single nanoparticle (NP) represents a key advantage of nanomedicine compared to traditional medical approaches. This is well represented by radiotherapy in which the dose of ionizing radiation should be calibrated on sensitizers biodistribution. Ideally, this is possible when the drug acts both as radiation enhancer and imaging contrast agent. Here, an easy, one‐step, laser‐assisted synthetic procedure is used to generate iron–boron (Fe–B) NPs featuring the set of functions required to assist neutron capture therapy (NCT) with magnetic resonance imaging. The Fe–B NPs exceed by three orders of magnitude the payload of boron isotopes contained in clinical sensitizers. The Fe–B NPs have magnetic properties of interest also for magnetophoretic accumulation in tissues and magnetic hyperthermia to assist drug permeation in tissues. Besides, Fe–B NPs are biocompatible and undergo slow degradation in the lysosomal environment that facilitates in vivo clearance through the liver–spleen–kidneys pathway. Overall, the Fe–B NPs represent a new promising tool for future exploitation in magnetic resonance imaging‐guided boron NCT at higher levels of efficacy and tolerability.
Abstract 16510: Hispanic Patients With Coronary Heart Disease Have Lower Cardiac Rehabilitation Participation Rates Than Non-Hispanics
Authors: Nainjot K Bains, Santiago R Nuño, Yu-Xuan Dang, Michelle Hsu, Armando Gallegos, Omar Viramontes, Kyle Udd-Garnica, Ignacio Zepeda, Luis R Castellanos
Journal: Circulation (2018)

Introduction: Cardiac rehabilitation (CR) is a multifaceted medical therapy aimed at improving morbidity and mortality in patients with coronary heart disease (CHD). Despite its proven benefits, CR...
MEK-ing the Most of It: Strategies to Co-target Gαq and MAPK in Uveal Melanoma
Authors: Sathya Neelature Sriramareddy, Keiran S.M. Smalley
Journal: Clinical Cancer Research (2020)

Most uveal melanomas harbor mutations in Gαq and show constitutive MAPK activation. Although MEK inhibition has some efficacy against uveal melanoma, clinical responses are typically poor. The Gαq inhibitor-MEK inhibitor combination showed prolonged suppression of MAPK signaling in preclinical uveal melanoma models and led to improved therapeutic responses.See related article by Hitchman et al., p. 1476.
SARS-CoV-2 Infection in the Early Post-Transplant Period After a Living Donor Kidney Transplant
Authors: Ashay Shingare, Madan Bahadur, Chandan L. Chaudhari, Pankaj G. Ganvir, Sharad A. Garudkar, Shaurya Mehta, Harsh P. Shah, Irawati R. Waghmare, Neville Colaco
Journal: Journal of the American Society of Nephrology (2020)

Shingare, Ashay; Bahadur, Madan; Chaudhari, Chandan L.; Ganvir, Pankaj G.; Garudkar, Sharad A.; Mehta, Shaurya; Shah, Harsh P.; Waghmare, Irawati R.; Colaco, Neville Author Information
Impact of HIV Infection on the Course of Inflammatory Bowel Disease and Drug Safety Profile: A Multicenter GETAID Study
Authors: Lucas Guillo, Mathieu Uzzan, Laurent Beaugerie, Jean-Marc Gornet, Aurélien Amiot, Anne-Laure Pelletier, Romain Altwegg, David Laharie, Vered Abitbol, Jérôme Filippi, Felix Goutorbe, Maria Nachury, Stéphane Nancey, Stéphanie Viennot, Catherine Reenaers, Morgane Amil, Ludovic Caillo, Anthony Buisson, Michael Collins, Laurence Picon, Mathias Vidon, Alban Benezech, Christian Rabaud, Cédric Baumann, Hélène Rousseau, Grégory Dubourg, Mélanie Serrero, Laurent Peyrin-Biroulet
Journal: Clinical Gastroenterology and Hepatology (2020)

Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), and human immunodeficiency virus (HIV) both impact innate and adaptive immunity in the intestinal mucosa. As it is a rare situation, the intersection between HIV and IBD remains unclear, especially the impact of HIV infection on the course of IBD, and the drug safety profile is unknown.We conducted a multicenter retrospective cohort study between January 2019 and August 2020. All adult patients with IBD and concomitant HIV infection were included. Each IBD patient with HIV was matched to two HIV-uninfected IBD patients.Overall, 195 patients with IBD were included, including 65 HIV-infected patients and 130 without HIV infection. Of the 65 infected patients, 22 (33.8%) required immunosuppressants and 31 (47.7%) biologics. In the HIV-infected group, the need for immunosuppressants (p = 0.034 for CD and p = 0.012 for UC) and biologics (p = 0.004 for CD and p = 0.008 for UC) was significantly lower. The disease course, using a severity composite criterion, was not significantly different between the two groups for CD (hazard ration (HR) = 1.3 [0.7; 2.4], p = 0.45) and UC (HR, 1.1 [0.5; 2.7], p = 0.767). The overall drug safety profile was statistically similar between the two groups.Although HIV-infected patients receive less treatments, the course of their IBD did not differ than uninfected, suggesting that HIV infection might attenuate IBD. The drug safety profile is reassuring, allowing physician to treat these patients according to current recommendations.
Aplidin (Plitidepsin) Regulates Viability and Function of Myeloma Cells and Bone Cells in Combination with Other Anti-MM Drugs
Authors: Jesus Delgado-Calle, Emily G Atkinson, Jessica Nelson, Noriyoshi Kurihara, Carlos Galmarini, David David Roodman, Teresita Bellido
Journal: Blood (2017)
Assessment of Standardization and International Scale (IS) Alignment Efforts of BCR-ABL1 Testing By the Chinese CML Alliance in an International External Quality Assessment Program
Authors: Ya-Zhen Qin, Stuart Scott, Dao-Xin Ma, Jian-Nong Cen, Cong Han, Min Xiao, Jordan Clark, Peng Zhao, Biao Yin, Annie Tapley, Debbie Travis, Liam Whitby, David Barnett, Xiao-Jun Huang
Journal: Blood (2017)
The sensory representation of causally controlled objects
Authors: Kelly B. Clancy, Thomas D. Mrsic-Flogel
Journal: Neuron (2020)

Intentional control over external objects is informed by our sensory experience of them. To study how causal relationships are learned and effected, we devised a brain machine interface (BMI) task using wide-field calcium signals. Mice learned to entrain activity patterns in arbitrary pairs of cortical regions to guide a visual cursor to a target location for reward. Brain areas that were normally correlated could be rapidly reconfigured to exert control over the cursor in a sensory-feedback-dependent manner. Higher visual cortex was more engaged when expert but not naive animals controlled the cursor. Individual neurons in higher visual cortex responded more strongly to the cursor when mice controlled it than when they passively viewed it, with the greatest response boosting as the cursor approached the target location. Thus, representations of causally controlled objects are sensitive to intention and proximity to the subject's goal, potentially strengthening sensory feedback to allow more fluent control.
Discovery of a Novel Polymer for Xeno‐Free, Long‐Term Culture of Human Pluripotent Stem Cell Expansion
Authors: Aishah Nasir, Jordan Thorpe, Laurence Burroughs, Joris Meurs, Sara Pijuan‐Galito, Derek J. Irvine, Morgan R. Alexander, Chris Denning
Journal: Advanced Healthcare Materials (2020)

Human pluripotent stem cells (hPSCs) can be expanded and differentiated in vitro into almost any adult tissue cell type, and thus have great potential as a source for cell therapies with biomedical application. In this study, a fully-defined polymer synthetic substrate is identified for hPSC culture in completely defined, xenogenic (xeno)-free conditions. This system can overcome the cost, scalability, and reproducibility limitations of current hPSC culture strategies, and facilitate large-scale production. A high-throughput, multi-generational polymer microarray platform approach is used to test over 600 unique polymers and rapidly assess hPSC-polymer interactions in combination with the fully defined xeno-free medium, Essential 8 (E8). This study identifies a novel nanoscale phase separated blend of poly(tricyclodecane-dimethanol diacrylate) and poly(butyl acrylate) (2:1 v/v), which supports long-term expansion of hPSCs and can be readily coated onto standard cultureware. Analysis of cell-polymer interface interactions through mass spectrometry and integrin blocking studies provides novel mechanistic insight into the role of the E8 proteins in promoting integrin-mediated hPSC attachment and maintaining hPSC signaling, including ability to undergo multi-lineage differentiation. This study therefore identifies a novel substrate for long-term serial passaging of hPSCs in serum-free, commercial chemically-defined E8, which provides a promising and economic hPSC expansion platform for clinical-scale application.
Abstract 11434: Low Level Elevation of Highly-Sensitive Cardiac Troponin I after Non-ST Elevation Acute Coronary Syndrome and Early Risk of Cardiac Ischemia and Ventricular Tachycardia: Analysis from MERLIN-TIMI 36
Authors: Jacob A Udell, Marc P Bonaca, Eugene Braunwald, Elain P Hoffman, Satishkumar Mohanavelu, Petr Jarolim, Conrad J Michael, Nihar R Desai, Marc S Sabatine, David A Morrow, Benjamin M Scirica
Journal: Circulation (2012)

Background: In patients (pts) presenting with NSTEACS, detection of low-level elevations of cardiac troponin (cTn) using high-sensitivity assays, previously undetectable by conventional assays, is ...
Screening for pulmonary arterial hypertension in adults carrying a <i>BMPR2</i> mutation
Authors: David Montani, Barbara Girerd, Xavier Jaïs, Pierantonio Laveneziana, Edmund M.T. Lau, Amir Bouchachi, Sébastien Hascoët, Sven Günther, Laurent Godinas, Florence Parent, Christophe Guignabert, Antoine Beurnier, Denis Chemla, Philippe Hervé, Mélanie Eyries, Florent Soubrier, Gérald Simonneau, Olivier Sitbon, Laurent Savale, Marc Humbert
Journal: European Respiratory Journal (2020)

Background Heritable pulmonary arterial hypertension (PAH) is most commonly due to heterozygous mutations of the BMPR2 gene. Based on expert consensus, guidelines recommend annual screening echocardiography in asymptomatic BMPR2 mutation carriers. The main objectives of this study were to evaluate the characteristics of asymptomatic BMPR2 mutation carriers, assess their risk of occurrence of PAH and detect PAH at an early stage in this high-risk population. Methods Asymptomatic BMPR2 mutation carriers underwent screening at baseline and annually for a minimum of 2 years (DELPHI-2 study; ClinicalTrials.gov : NCT01600898 ). Annual screening included clinical assessment, ECG, pulmonary function tests, 6-min walk distance, cardiopulmonary exercise testing, chest radiography, echocardiography and brain natriuretic peptide (BNP) or N-terminal (NT)-proBNP level. Right heart catheterisation (RHC) was performed based on predefined criteria. An optional RHC at rest and exercise was proposed at baseline. Results 55 subjects (26 males; median age 37 years) were included. At baseline, no PAH was suspected based on echocardiography and NT-proBNP levels. All subjects accepted RHC at inclusion, which identified two mild PAH cases (3.6%) and 12 subjects with exercise pulmonary hypertension (21.8%). At long-term follow-up (118.8 patient-years of follow-up), three additional cases were diagnosed, yielding a PAH incidence of 2.3% per year (0.99% per year in males and 3.5% per year in females). All PAH cases remained at low-risk status on oral therapy at last follow-up. Conclusions Asymptomatic BMPR2 mutation carriers have a significant risk of developing incident PAH. International multicentre studies are needed to confirm that refined multimodal screening programmes with regular follow-up allow early detection of PAH.
THU0126 Dexterity and anxiety in large cohort of rheumatoid arthritis patients
Authors: SJ Stropuviene, J Jankauskiene, J Dadoniene, A Venalis
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> Psychological distress is often a leading condition in rheumatoid arthritis clinical picture in addition to disability and disease activity measures. Being long lasting process it makes an impact on disease coping process and management itself.<sup>1</sup> <h3>Objectives</h3> The aim of the study was to determine which demographic and clinical variables relate to anxiety and depression most of all in 225 rheumatoid arthritis (RA) patients cohort. <h3>Methods</h3> The study was performed as satellite project to Vilnius rheumatoid arthritis register. The patients were invited to participate in the study and to answer the questions concerning education and employment, physical phunctioning: ACR functional classes, dependence on relatives and HAQ and patients global assessment of health status. The disease activity was measured by physicians global assessment, pain VAS, morning stiffness and modified DAS. Anxiety and depression were measured by AIMS2 questioner particularly asking about mood alterations with range of possible answers: 1-never and 6-almost ever. The level 6,0 for anxiety and 4,0 for dexterity were used as cut of levels.<sup>2</sup> The chi-square method was used for evaluation of associations and was qualified as significant if p &lt; 0,05. <h3>Results</h3> In this particular cohort we found that 32% of patients were experiencing the anxiety and even 42,2% – depressive moods. As the result, we found strong associations between anxiety levels with disease outcome measures: physical functioning classes (chi2 = 12,72; p = 0,00), disability indices (chi2 = 21,09; p = 0,00) and employment holding (chi2 = 5,62; p = 0,01). Global evaluation of disease activity by physician was the only one significantly correlated disease activity measure (chi2 = 12,51; p = 0,00). Dexterity levels showed the same significant associations with the same measures. In addition to it dexterity had one more additional significant association: the dependence on relatives made those patients evidently depressed (chi2 = 12,96; p = 0,00) but not anxious. <h3>Conclusion</h3> The anxiety and depression status of 225 Ra patients turned out to be multidependent variables in strong association with social status, disability indices and ACR classes but physicians global assessment as the only one disease activity measure. <h3>References</h3> Meenan RF, Gertman PM, Mason JH, Dunaif R. The arthritis impact measures scales. Arthritis Rheum. 1982;25:1048–53 Hawley DJ, Wolfe F. Anxiety and depression in patients with rheumatoid arthritis: a prospective study of 400 patients. J Rheumatol. 1988;15:932–41
Ventricular Remodeling: Fundamental to the Progression (and Regression) of Heart Failure⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Authors: James E. Udelson, Marvin A. Konstam
Journal: Journal of the American College of Cardiology (2011)
Characteristics and Outcome of AKI Needing Dialysis with COVID-19 Infection
Authors: Suresh Sankarasubbaiyan, Mallikarjuna Gowda B. Gowda, Venkatraman Ganapathi Subraman, Mohammad S. Husain, Vikram A. Sonawane, Satyanarayana R. Puvvada, Kaparaboina K. Kumar, Guruvulu Venkata, Kamal D. Shah
Journal: Journal of the American Society of Nephrology (2020)

Sankarasubbaiyan, Suresh; Gowda, Mallikarjuna Gowda B.; Subraman, Venkatraman Ganapathi; Husain, Mohammad S.; Sonawane, Vikram A.; Puvvada, Satyanarayana R.; Kumar, Kaparaboina K.; Venkata, Guruvulu; Shah, Kamal D. Author Information
The COURAGE (Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation) Trial: Can We Deliver on Its Promise?⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Authors: Patrick T. O'Gara
Journal: Journal of the American College of Cardiology (2010)
Danish mask study: masks, media, fact checkers, and the interpretation of scientific evidence
Authors: Simon Thornley, Michael D Jackson, Gerhard Sundborn
Journal: BMJ (2020)

The results of the Danmask-191 trial1—which, by conventional interpretation, showed that wearing masks had no effect on the prevention of covid-19 spread—are contested. An editorial for The BMJ disagreed with convention and criticised the labelling of the “no effect” reading by Oxford professors Heneghan and Jefferson as “false information.”2 We were also labelled “misleading” after our “no effect” interpretation. …
Endoscopic management of enteral tubes in adult patients – Part 2: Peri- and post-procedural management. European Society of Gastrointestinal Endoscopy (ESGE) Guideline
Authors: Paraskevas Gkolfakis, Marianna Arvanitakis, Edward J. Despott, Asuncion Ballarin, Torsten Beyna, Kurt Boeykens, Peter Elbe, Ingrid Gisbertz, Alice Hoyois, Ofelia Mosteanu, David S. Sanders, Peter T. Schmidt, Stéphane M. Schneider, Jeanin E. van Hooft
Journal: Endoscopy (2020)

Main recommendations ESGE recommends the “pull” technique as the standard method for percutaneous endoscopic gastrostomy (PEG) placement. Strong recommendation, low quality evidence. ESGE recommends the direct percutaneous introducer (“push”) technique for PEG placement in cases where the “pull” method is contraindicated, for example in severe esophageal stenosis or in patients with head and neck cancer (HNC) or esophageal cancer. Strong recommendation, low quality evidence. ESGE recommends the intravenous administration of a prophylactic single dose of a beta-lactam antibiotic (or appropriate alternative antibiotic, in the case of allergy) to decrease the risk of post-procedural wound infection. Strong recommendation, moderate quality evidence. ESGE recommends that inadvertent insertion of a nasogastric tube (NGT) into the respiratory tract should be considered a serious but avoidable adverse event (AE). Strong recommendation, low quality evidence. ESGE recommends that each institution should have a dedicated protocol to confirm correct positioning of NGTs placed “blindly” at the patient’s bedside; this should include: radiography, pH testing of the aspirate, and end-tidal carbon dioxide monitoring, but not auscultation alone. Strong recommendation, low quality evidence. ESGE recommends confirmation of correct NGT placement by radiography in high-risk patients (intensive care unit [ICU] patients or those with altered consciousness or absent gag/cough reflex). Strong recommendation, low quality evidence. ESGE recommends that EN may be started within 3 – 4 hours after uncomplicated placement of a PEG or PEG-J. Strong recommendation, high quality evidence. ESGE recommends that daily tube mobilization (pushing inward) along with a loose position of the external PEG bumper (1 – 2 cm from the abdominal wall) could mitigate the risk of development of buried bumper syndrome. Strong recommendation, low quality evidence.
Tracking HIV Rebound following Latency Reversal Using Barcoded HIV
Authors: Matthew D. Marsden, Tian-hao Zhang, Yushen Du, Melanie Dimapasoc, Mohamed S.A. Soliman, Xiaomeng Wu, Jocelyn T. Kim, Akira Shimizu, Adam Schrier, Paul A. Wender, Ren Sun, Jerome A. Zack
Journal: Cell Reports Medicine (2020)

HIV latency prevents cure of infection with antiretroviral therapy (ART) alone. One strategy for eliminating latently infected cells involves the induction of viral protein expression via latency-reversing agents (LRAs), allowing killing of host cells by viral cytopathic effects or immune effector mechanisms. Here, we combine a barcoded HIV approach and a humanized mouse model to study the effects of a designed, synthetic protein kinase C modulating LRA on HIV rebound. We show that administration of this compound during ART results in a delay in rebound once ART is stopped. Furthermore, the rebounding virus appears composed of a smaller number of unique barcoded viruses than occurs in control-treated animals, suggesting that some reservoir cells that would have contributed virus to the rebound process are eliminated by LRA administration. These data support the use of barcoded virus to study rebound and suggest that LRAs may be useful in HIV cure efforts.
Emerging paradigms in metastasis research
Authors: Ashik Ahmed Abdul Pari, Mahak Singhal, Hellmut G. Augustin
Journal: The Journal of Experimental Medicine (2020)

Historically, therapy of metastatic disease has essentially been limited to using strategies that were identified and established to shrink primary tumors. The limited efficacy of such treatments on overall patient survival stems from diverging intrinsic and extrinsic characteristics of a primary tumor and metastases originating therefrom. To develop better therapeutic strategies to treat metastatic disease, there is an urgent need to shift the paradigm in preclinical metastasis research by conceptualizing metastatic dissemination, colonization, and growth as spatiotemporally dynamic processes and identifying rate-limiting vulnerabilities of the metastatic cascade. Clinically, while metastatic colonization remains the most attractive therapeutic avenue, comprehensive understanding of earlier steps may unravel novel metastasis-restricting therapies for presurgical neoadjuvant application. Moving beyond a primary tumor-centric view, this review adopts a holistic approach to understanding the spatial and temporal progression of metastasis. After reviewing recent developments in metastasis research, we highlight some of the grand challenges and propose a framework to expedite mechanism-based discovery research feeding the translational pipeline.
Caring for Patients with Kidney Disease in the COVID-19 Era: The Kaiser Permanente Northern California Experience
Authors: Sijie Zheng, Ali Poyan-Mehr, Leonid Pravoverov, Sharina Belani
Journal: Journal of the American Society of Nephrology (2020)

Background: The COVID-19 pandemic has presented health care system in the United States with unprecedented challenges  Kaiser Permanente Northern California is an integrated health care system with 4 5 million members, who are cared for by The Permanente Medical Group (TPMG), a multiple specialty medical group of 10,000 physicians  Utilizing coordinated care, sophisticated Electric Medical Record system  KPNC Nephrology service line has developed several strategies to mitigate the effect of COVID-19, including rapidly increased video visit appointments for members with CKD  Methods: After the 'Shelter in place' order in March 2020, KP nephrologists started weekly virtual townhall meetings to coordinate care among 85 nephrologists in 19 hospitals covering patients with chronic kidney disease, receiving dialysis, and post kidney transplant  TPMG nephrologists have developed guidelines on: 1  Tier testing for Person Under Investigation (PUI) members;2  Management of patients with Glomerulonephritis;3  Post-kidney transplant care;4  Expand advance care planning;5  Converting direct patient visits to video visits;6  Coordinating care with contracted dialysis providers for members on outpatient dialysis  Results: The video visits have increased 780% from March to April and 1968% from March to May of 2020 (Figure)  The top three diagnosis for video visits were: CKD3, CKD4, and post kidney transplant  Since April 8, 2020, average 0 038% of Dialysis patients were tested positive for COVID-19 and average 1 6% are PUI  Conclusions: As an integrated health care system, KPNC has developed a systematic, collaborative and rapid crisis management of patients with CKD in COVID era  Further studies are needed to evaluate the long-term outcomes of these approaches