tbuckley/cabot-search huggingface dataset:
Association between Cold Spells and Mortality Risk and Burden: A Nationwide Study in China
Authors: Jian Lei, Renjie Chen, Peng Yin, Xia Meng, Lina Zhang, Cong Liu, Yang Qiu, John S. Ji, Haidong Kan, Maigeng Zhou
Journal: Environmental Health Perspectives (2022)

Background: Few multicity studies have evaluated the association between cold spells and mortality risk and burden. Objectives: We aimed to estimate the association between cold spells and cause-specific mortality and to evaluate the mortality burden in China. Methods: We conducted a time-series analysis with a nationally representative Disease Surveillance Points System database during the cool seasons spanning from 2013 to 2015 in 272 Chinese cities. We used 12 cold-spell definitions and overdispersed generalized additive models with distributed lag models to estimate the city-specific cumulative association of cold spells over lags of 0–28 d. We controlled for the nonlinear and lagged effects of cold temperature over 0–28 d to evaluate the added effect estimates of cold spell. We also quantified the nationwide mortality burden and pooled the estimated association at national and different climatic levels with meta-regression models. Results: For the cold-spell definition of daily mean temperatures of ≤5th percentile of city-specific daily mean temperature and duration of ≥4 consecutive d, the relative risks (i.e., risk ratios) associated with cold spells were 1.39 [95% confidence interval (CI): 1.15, 1.69] for non-accidental mortality, 1.66 (95% CI: 1.20, 2.31) for coronary heart disease mortality, 1.49 (95% CI: 1.12, 1.97) for stroke mortality, and 1.26 (95% CI: 0.85, 1.87) for chronic obstructive pulmonary disease mortality. Cold spells showed a maximal lagged association of 28 d with the risks peaked at 10–15 d. A statistically significant attributable fraction (AF) of non-accidental mortality [2.10% (95% CI: 0.94%, 3.04%)] was estimated. The risks were higher in the temperate continental and the temperate monsoon zones than in the subtropical monsoon zone. The elderly population was especially vulnerable to cold spells. Discussion: Our study provides evidence for the significant relative risks of non-accidental, cardiovascular, and respiratory mortality associated with cold spells. The findings on vulnerable populations and differential risks in different climatic zones may help establish region-specific forecasting systems against the hazardous impact of cold spells. https://doi.org/10.1289/EHP9284
A MACHINE LEARNING ALGORITHM TO PREDICT LEFT VENTRICULAR DIASTOLIC DYSFUNCTION BY CARDIAC MAGNETIC RESONANCE IMAGING
Authors: Qingtao Zhou, Lin Wang, Eddy Barasch, Michael Passick, Jason Craft, Jonathan Weber, Nora Ngai, Jonathan Scheiner, Kaitlyn Quijano, Shreya Rao, Jie J. Cao
Journal: Journal of the American College of Cardiology (2022)
Global mortality burden attributable to non-optimal temperatures – Authors’ reply
Authors: Katrin G Burkart, Michael Brauer, Aleksandr Y Aravkin, William W Godwin, Simon I Hay, Jaiwei He, Vincent C Iannucci, Samantha L Larson, Stephen S Lim, Jiangmei Liu, Christopher J L Murray, Peng Zheng, Maigeng Zhou, Jeffrey D Stanaway
Journal: The Lancet (2022)
CLINICAL OUTCOMES AND RATE OF READMISSION AFTER ACUTE MYOCARDIAL INFARCTION IN PATIENTS WITH AND WITHOUT SYSTEMIC LUPUS ERYTHEMATOSUS: A NATIONWIDE ANALYSIS
Authors: Shazib Sagheer, Ann Annis, Dola Pathak, Pallav Deka, Syeda H. Zaidi, Umair A. Khan, Abdul Mannan Khan Minhas, James C. Blankenship
Journal: Journal of the American College of Cardiology (2022)
EICOSAPENTAENOIC ACID (EPA) REDUCES INFLAMMATION AND IMPROVES NITRIC OXIDE BIOAVAILABILITY IN PULMONARY ENDOTHELIAL CELLS FOLLOWING EXPOSURE TO AIR POLLUTION PARTICLES
Authors: Samuel CR R. Sherratt, Hazem Dawoud, Peter Libby, Deepak L. Bhatt, Tadeusz Malinski, R. Preston Mason
Journal: Journal of the American College of Cardiology (2022)
Consents (and Contents) Under Pressure: Maintaining Space for Moral Engagement in Research Protocols
Authors: Virginia L. Bartlett, Mark J. Bliton, Stuart G. Finder
Journal: The American Journal of Bioethics (2022)

This article is referred to by:A New Ethical Framework for Assessing the Unique Challenges of Fetal Therapy Trials: Response to CommentariesFetal Therapies and Clinical Research: Beyond Risk and BenefitWhat Lies Beneath the Framework: The Importance of Grounding Ethical Discussions of Maternal-Fetal Therapy
Hyperthermic Intraperitoneal Chemotherapy for the Treatment of Epithelial Ovarian Cancer
Authors: Stephanie L. Wethington, Deborah K. Armstrong, Fabian M. Johnston
Journal: JAMA Surgery (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Abstract P5-01-12: Physical and visual (social) isolation increases tumor aggressiveness in thermoneutral housing temperatures in murine mammary cancer models
Authors: Darius O Gaymon
Journal: Cancer Research (2022)

Abstract Correct interpretation of tumor progression data , including the influence of host biology, in mouse models of breast cancer requires models and conditions that faithfully recapitulate human disease and human host status. Our previous attempts to investigate the effects of social isolation have proven inconclusive due to premature mortality in tumor-bearing animals. Those studies were completed in standard temperature (ST), which commonly is 70-72°F (21-22°C) for in vivo murine research based on laboratory animal care and use guidelines. Previous work from the Repasky lab (Kokulus, 2013) , which we have validated (Gaymon, 2020), demonstrates that ST housing results in chronic cold stress and immune suppression mediated by an increase in norepinrephrine (NE) levels, leading to increased tumor aggressiveness. Based on these findings, we investigated the effects of social isolation on BALB/cJ-4T1-luc and C57BL/6J/E0771 tumor progression and metastasis in thermoneutral housing conditions (84-85°F). Mice were first acclimatized to thermoneutral temperature and/or isolation for two weeks in cages that were unilaterally draped to provide physical and visual isolation. In BALB/cJ mice, 4T1-luc tumors were significantly larger in isolated mice compared to group-housed (GH) mice at day 18 (p&amp;lt;.0001). Statistically larger tumors were observed in isolated mice compared to GH mice through day 24 and final tumor masses were also significantly different (p=.004). Spleen masses were not statistically different. In C57BL/6J mice, E0771 tumors were significantly larger in isolates at Day 25 (p=.002). Final tumor masses were statistically (p=.002) different while no difference in spleen sizes were observed. Data on metastasis will be presented at the meeting. We hypothesized that social isolation may perturb immune function and next investigated the growth of 4T1-luc xenograft tumors in NSG mice. 4T1-luc/NSG tumor progression and metastasis data will also be presented at the meeting. We conclude that syngeneic breast tumor growth in immunocompetent BALB/cJ and C57BL/6J mice demonstrates that social isolation is a bona fide stress with sufficient influence to exacerbate breast cancer growth. These data are potentially clinically important due the known relationship of social support to survivorship outcomes in patients and the high-risk of depression and isolation in patients following breast cancer diagnosis. The data may provide additional insight into possible effects of COVID-19 isolation on breast cancer progression. Citation Format: Darius O Gaymon. Physical and visual (social) isolation increases tumor aggressiveness in thermoneutral housing temperatures in murine mammary cancer models [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P5-01-12.
LIPOPROTEIN(A) LEVELS AMONG HISPANIC/LATINO INDIVIDUALS RESIDING IN THE UNITED STATES: RESULTS FROM THE HISPANIC COMMUNITY HEALTH STUDY/STUDY OF LATINOS (HCHS/SOL)
Authors: Parag Joshi, Santica Marcovina, Kate Orroth, J. Antonio G. Lopez, Shia Kent, Robert Kaplan, Katrina Swett, Daniela Sotres-Alvarez, Bharat Thyagarajan, Tamer Sofer, Martha Daviglus, Gregory Talavera, Neil Schneiderman, Carlos Jose Rodriguez
Journal: Journal of the American College of Cardiology (2022)
Enhancing HIV Prevention With New Modalities and Routine Sexual History Discussions
Authors: Kenneth H. Mayer, Lao-Tzu Allan-Blitz
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Are They Side Effects? Extraintestinal Symptoms Reported During Clinical Trials of Irritable Bowel Syndrome May Be More Severe at Baseline
Authors: Sarah Ballou, Rafla Hassan, Judy Nee, Johanna Iturrino, Vikram Rangan, Vivian Cheng, Lisa Conboy, Irving Kirsch, Anthony Lembo, Ted J. Kaptchuk, John Kelley
Journal: Clinical Gastroenterology and Hepatology (2022)
PROGNOSTIC VALUE OF AN ARTIFICIAL INTELLIGENCE ENHANCED ECG MODEL IN CARDIAC AMYLOIDOSIS
Authors: Jennifer Amadio, Angela Dispenzieri, Francisco Lopez-Jimenez, Zachi Itzhak Attia, Omar Abou Ezzeddine, Grace Lin, Daniel Dean Borgeson, Paul A. Friedman, Eli Muchtar, Morie Gertz, Dennis H. Murphree, Martha Grogan
Journal: Journal of the American College of Cardiology (2022)
QIM22-193: Development and Implementation of a Scheduling Tool to Improve Patient Access to Outpatient Care in an Academic Cancer Center
Authors: Shelton Lacy Harrell, Karline Peal, Nicole Freitas, Heather Jackson
Journal: Journal of the National Comprehensive Cancer Network (2022)

"QIM22-193: Development and Implementation of a Scheduling Tool to Improve Patient Access to Outpatient Care in an Academic Cancer Center" published on 31 Mar 2022 by National Comprehensive Cancer Network.
The world’s refugees remain last in line for covid-19 vaccines
Authors: Sally Howard, Geetanjali Krishna
Journal: BMJ (2022)

major barrier to covid-19 vaccination for the world's displaced people, report Sally Howard and Geetanjali Krishna Sally Howard, 1 Geetanjali Krishna 2 Jannat Bahar, a 45 year old single mother of eight children, sits behind a wooden grocery stand in the Rohingya refugee camp in Mewat, a small town in the Indian state of Haryana.Bahar fled to India several years ago but still cannot speak Hindi, India's lingua franca."When the covid vaccination drive was held in my camp, some people came to explain why it was necessary," she says."But I didn't understand a word."Over four months since the vaccine drive to reach the 1750 refugees living in Mewat, Bahar remains unvaccinated.Mir Khan, 72, a labourer and Hindu Pakistani refugee living in Anganwa camp in Jodhpur, says that vaccination became a means of stigmatising the refugees who worked as day labourers as they were not initially offered vaccines when host nationals were."Many people in the camp were unable to get even daily wage work because their employers feared that they might spread infection," he says.
Human and mouse trigeminal ganglia cell atlas implicates multiple cell types in migraine
Authors: Lite Yang, Mengyi Xu, Shamsuddin A. Bhuiyan, Jia Li, Jun Zhao, Randall J. Cohrs, Justin T. Susterich, Sylvia Signorelli, Ursula Green, James R. Stone, Dan Levy, Jochen K. Lennerz, William Renthal
Journal: Neuron (2022)
INCREASED INCIDENCE OF HEART FAILURE AND COMORBID MENTAL HEALTH CONDITIONS AMONG 3.8 MILLION UNITED STATES VETERANS
Authors: Jamie L. Pfaff, Svetlana Eden, Charles Alcorn, Shi Huang, Jeffrey Annis, Suman Kundu, Matthew Freiberg, Evan L. Brittain
Journal: Journal of the American College of Cardiology (2022)
Abstract ES4-1: Acupuncture
Authors: T Bao
Journal: Cancer Research (2022)

Abstract Acupuncture is a Traditional Chinese Medicine technique that involves inserting and manipulating filiform needles into specific points on the body to alleviate symptoms. Although its mechanisms are not fully established, acupuncture appears to interact with and modulate the functioning of nerves, neurotransmitters, and neurohormones. Acupuncture has been used as a complementary therapy to treat a wide range of conditions experienced by breast cancer survivors. In this education session, I will discuss the use of acupuncture to reduce breast cancer treatment-related toxicities such as chemotherapy-induced nausea, vomiting, peripheral neuropathy, and cognitive-impairment; insomnia; hot flashes; and aromatase inhibitor-associated arthralgias. I will start by discussing the definition and mechanisms of acupuncture. I will then share clinical evidence and ongoing trials supporting and investigating the use of acupuncture for these toxicities, and end with a summary of my recommendations. Citation Format: T Bao. Acupuncture [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr ES4-1.
NRF2: KEAPing Tumors Protected
Authors: Ray Pillai, Makiko Hayashi, Anastasia-Maria Zavitsanou, Thales Papagiannakopoulos
Journal: Cancer Discovery (2022)

The Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2-related factor 2 (NRF2) pathway plays a physiologic protective role against xenobiotics and reactive oxygen species. However, activation of NRF2 provides a powerful selective advantage for tumors by rewiring metabolism to enhance proliferation, suppress various forms of stress, and promote immune evasion. Genetic, epigenetic, and posttranslational alterations that activate the KEAP1/NRF2 pathway are found in multiple solid tumors. Emerging clinical data highlight that alterations in this pathway result in resistance to multiple therapies. Here, we provide an overview of how dysregulation of the KEAP1/NRF2 pathway in cancer contributes to several hallmarks of cancer that promote tumorigenesis and lead to treatment resistance.Alterations in the KEAP1/NRF2 pathway are found in multiple cancer types. Activation of NRF2 leads to metabolic rewiring of tumors that promote tumor initiation and progression. Here we present the known alterations that lead to NRF2 activation in cancer, the mechanisms in which NRF2 activation promotes tumors, and the therapeutic implications of NRF2 activation.
RELATIONSHIP AMONG IN-STENT NEOATHEROSCLEROSIS AND EXTENT OF LIPID-RICH PLAQUE IN PATIENTS WITH CORONARY ARTERY DISEASE: AN OPTICAL COHERENCE TOMOGRAPHY AND NEAR-INFRARED SPECTROSCOPY STUDY
Authors: Mitsuhiro Takeuchi, Tomotaka Dohi, Tatsuya Fukase, Nishio Ryota, Norihito Takahashi, Hirohisa Endo, Shinichiro Doi, Hiroki Nishiyama, Iwao Okai, Hiroshi Iwata, Shinya Okazaki, Katsumi Miyauchi, Hiroyuki Daida, Tohru Minamino
Journal: Journal of the American College of Cardiology (2022)
The association of improvement in left ventricular ejection fraction with outcomes in patients with heart failure with reduced ejection fraction: data from <scp>CHAMP‐HF</scp>
Authors: Adam D. DeVore, Anne S. Hellkamp, Laine Thomas, Nancy M. Albert, Javed Butler, J. Herbert Patterson, John A. Spertus, Fredonia B. Williams, Xian Shen, Adrian F. Hernandez, Gregg C. Fonarow
Journal: European Journal of Heart Failure (2022)
SARS-CoV-2 Omicron Variant Neutralization after mRNA-1273 Booster Vaccination
Authors: Rolando Pajon, Nicole A Doria-Rose, Xiaoying Shen, Stephen D Schmidt, Sijy O'Dell, Charlene McDanal, Wenhong Feng, Jin Tong, Amanda Eaton, Maha Maglinao, Haili Tang, Kelly E Manning, Venkata-Viswanadh Edara, Lilin Lai, Madison Ellis, Kathryn M Moore, Katharine Floyd, Stephanie L Foster, Christine M Posavad, Robert L Atmar, Kirsten E Lyke, Tongqing Zhou, Lingshu Wang, Yi Zhang, Martin R Gaudinski, Walker P Black, Ingelise Gordon, Mercy Guech, Julie E Ledgerwood, John N Misasi, Alicia Widge, Nancy J Sullivan, Paul C Roberts, John H Beigel, Bette Korber, Lindsey R Baden, Hana El Sahly, Spyros Chalkias, Honghong Zhou, Jing Feng, Bethany Girard, Rituparna Das, Anne Aunins, Darin K Edwards, Mehul S Suthar, John R Mascola, David C Montefiori
Journal: New England Journal of Medicine (2022)
Renal Extramedullary Hematopoiesis Incidentally Detected on 18F-FDG PET/CT Imaging
Authors: Gursan Kaya, Murat Fani Bozkurt
Journal: Clinical Nuclear Medicine (2022)

Abstract 18 F-FDG PET/CT imaging of a 68-year-old woman with a known clinical diagnosis of systemic lupus erythematosus and recent-onset ataxia revealed FDG-avid soft tissue masses in bilateral renal sinuses and mildly increased bone marrow activity. Consecutive tissue sampling with fine-needle biopsy from renal sinus masses confirmed mass-forming extramedullary hematopoiesis corresponding to FDG-avid soft tissue lesions. Here we present a rare case of bilateral mass-forming extramedullary hematopoiesis at renal sinuses incidentally detected on 18 F-FDG PET/CT imaging.
Tumor budding is an independent prognostic factor in stage III colon cancer patients: a post-hoc analysis of the IDEA-France phase III trial (PRODIGE-GERCOR)
Authors: D. Basile, C. Broudin, J.F. Emile, A. Falcoz, F. Pagès, L. Mineur, J. Bennouna, C. Louvet, P. Artru, S. Fratte, F. Ghiringhelli, T. André, V. Derangère, D. Vernerey, J. Taieb, M. Svrcek
Journal: Annals of Oncology (2022)
Clinical significance of FBXW7 loss of function in human cancers
Authors: Jingyi Fan, Marcia Bellon, Mingyi Ju, Lin Zhao, Minjie Wei, Liwu Fu, Christophe Nicot
Journal: Molecular Cancer (2022)

Abstract FBXW7 (F-Box and WD Repeat Domain Containing 7) (also referred to as FBW7 or hCDC4) is a component of the Skp1-Cdc53 / Cullin-F-box-protein complex (SCF/β-TrCP). As a member of the F-box protein family, FBXW7 serves a role in phosphorylation-dependent ubiquitination and proteasome degradation of oncoproteins that play critical role(s) in oncogenesis. FBXW7 affects many regulatory functions involved in cell survival, cell proliferation, tumor invasion, DNA damage repair, genomic instability and telomere biology. This thorough review of current literature details how FBXW7 expression and functions are regulated through multiple mechanisms and how that ultimately drives tumorigenesis in a wide array of cell types. The clinical significance of FBXW7 is highlighted by the fact that FBXW7 is frequently inactivated in human lung, colon, and hematopoietic cancers. The loss of FBXW7 can serve as an independent prognostic marker and is significantly correlated with the resistance of tumor cells to chemotherapeutic agents and poorer disease outcomes. Recent evidence shows that genetic mutation of FBXW7 differentially affects the degradation of specific cellular targets resulting in a distinct and specific pattern of activation/inactivation of cell signaling pathways. The clinical significance of FBXW7 mutations in the context of tumor development, progression, and resistance to therapies as well as opportunities for targeted therapies is discussed.
Follow-up Duration and Gender Differences in a Study of Older Adults Living Alone—Reply
Authors: Sachin J. Shah, Kenneth E. Covinsky
Journal: JAMA Internal Medicine (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal