tbuckley/cabot-search huggingface dataset:
Abstract 2752: Pulmonary Vein Isolation With And Without Additional Ablation Of Complex Fractionated Electrograms In Paroxysmal Atrial Fibrillation: Long-term Results Of A Prospective Randomized Study
Authors: Isabel Deisenhofer, Tilko Reents, Heidi L Estner, Stephanie Fichtner, Christian von Bary, Ekrem Uecer, Claus Schmitt, Armin Luik, Klinikum Karlsruhe, Martin R Karch, Gabriele Hessling
Journal: Circulation (2008)

Introduction: Segmental pulmonary vein isolation (PVI) leads to elimination of paroxysmal atrial fibrillation (AF) in approximately 75% of patients. Ablation of complex fractionated atrial electrograms (CFAE) is an alternative ablation strategy. In this prospective randomized study the long-term effect of PVI alone is compared to the effect of combined PVI and CFAE ablation in paroxysmal AF. Methods: 98 patients with paroxysmal AF (57±10 years, 74 male) were randomly assigned to PVI (48 patients) or PVI+CFAE ablation (50 patients). Additional CFAE ablation was performed in the PVI+CFAE group if AF was still inducible after PVI. Follow-up results were assessed with repetitive 7 days Holter ECG and clinical evaluation including repeat ablations. Results: Additional CFAE ablation was performed in 30/50 (60%) patients of the PVI+CFAE group with still inducible AF after PVI. In each group, 2 patients were lost to long term follow-up. In the intention-to-treat analysis at 3 months and after 19±8 months, there was no significant difference between both groups (36/48 [75%] and 34/46 [74%] patients in the PVI and 37/50 [73%] and 40/48 [83%] of patients in the PVI+CFAE ablation group in sinus rhythm [p=0.32]). In subgroup analysis, patients actually treated with the combined PVI+CFAE ablation approach had a significantly better long-term success (25/28; 89%) than patients with still inducible AF who underwent PVI only (22/30;73%; p=0.02). In both groups repeat ablations were performed in 31% (PVI group; 15/48 patients) and 35% (PVI+CFAE group; 17/48 patients) (p=n.s). After 9 months, significantly more patients in the PVI+CFAE group experienced sustained regular atrial tachycardia than in the PVI group (6/44 versus 1/39 patients, P=0.02). Conclusion: The combination of PVI and CFAE ablation was equally effective than PVI alone in reaching freedom of AF in the intention-to-treat analysis. During long-term follow-up, patients actually treated with combined PVI+CFAE ablation had a significantly better outcome (89% vs. 73%). However, the rate of ablation-induced regular atrial tachycardias is inreased.
Abstract 2070: Transmural Strain Gradient of Normal, Hyperemic and Ischemic LV Walls Evaluated by New 2D Speckle Tracking System
Authors: Koichi Kimura, Katsu Takenaka, Kansei Uno, Aya Ebihara, Kazuno Sasaki, Makoto Sonoda, Yasuhiko Abe, Tetsuya Kawagishi, Ryozo Nagai
Journal: Circulation (2007)

PURPOSE: Currently available 2D echo speckle tracking system can track the endocardial and epicardial echo, but cannot reliably track the speckles from the myocardium. We assessed feasibility of newly developed prototype speckle tracking system in humans with normal, hyperemic and ischemic LV. METHODS: LV short-axis images were obtained by 2D echo (Aplio, TOSHIBA) at rest in 46 normal subjects and 52 patients with clinically diagnosed myocardial infarction (28 with non-Q wave and 24 with Q wave infarction), and during ATP infusion (0.14mg/min/kg) in 21 normals. Using the new system which could track the “myocardial” speckle (Figure ), we measured circumferential strain of the LV endocardium (Endo), mid-wall (Mid) and epicardium (Epi). RESULTS: In normal subjects, circumferential strain showed distinct transmural gradient (p&lt;0.001, ANOVA) (Table ). ATP infusion increased Endo strain (p&lt;0.001) and steepened the gradient. Strain of ischemic region was extremely reduced (p&lt;0.001) in both non-Q and Q wave infarction group and the gradient was hardly recognized in the latter. CONCLUSION: “Myocardial” speckle tracking was feasible and can be used to evaluate the effects of coronary flow on transmural strain gradient. Figure. Speckle tracking of Mid as well as Endo and Epi
Normal (RT-PCR negative) stem cells can be collected following lenograstim therapy in chronic myeloid leukemia (CML) in major/complete cytogenetic response (MCR/CCR) on alpha-interferon (alpha-IFN).
Authors: K Taylor, R Rodwell, D Taylor, J Coulston, B Williams, D Moore, A Rentoul, C Kelly, J Morton, I Bunce, P Eliadis, P Marlton, S Mitchell, L Gautier
Journal: Blood (1995)
Pharmaceutical Botany. A Text Book of College Botany with Pharmaceutical and Medical Applications. Especially Adapted for the Use of Students of Pharmacy and Medicine and as a Reference for Pharmacists, Chemists and Students in Structural and Systematic Botany.
Authors: Heber W. Youngken
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 297: Haptoglobin Genotype is a Determinant of Oxidation and Inflammation in the Atherosclerotic Plaque
Authors: Andrew P Levy, Joanne E Levy, Shiri Kalet-Litman, Nina S Levy, Roy Asaf, Julia Guetta, K Raman Purushothaman, Valentin Fuster, Pedro Moreno
Journal: Circulation (2006)

Introduction. Intraplaque hemorrhage increases the risk of plaque rupture and thrombosis. The release of hemoglobin (Hb) from extravasated erythrocytes at the site of hemorrhage leads to iron depos...
Abstract 13467: Impact of Basal Thinning of the Interventricular Septum on Long-term Prognosis in Patients With Cardiac Sarcoidosis
Authors: Nobutaka Nagano, Toshiyuki Nagai, Yasuo Sugano, Yasuhide Asaumi, Satoshi Yasuda, Hisao Ogawa, Toshihisa Anzai
Journal: Circulation (2013)

Backgrounds: Basal thinning of the interventricular septum (IVS) is one of the key findings for diagnosing cardiac sarcoidosis (CS), and ideal cut-off thickness of basal IVS was previously reported...
Abstract 8105: The Nucleotide-Binding Oligomerization Domain-Containing Protein 1 Underlies Cardiac Apoptosis in Type 2 Diabetic Mice
Authors: Maria Fernandez-Velasco, Patricia Prieto, Veronica Terron, Carmen Delgado, Paloma Martín-Sanz, Lisardo Bosca
Journal: Circulation (2011)

Introduction. The pathogenesis of diabetic cardiomyopathy is complex, and involves deregulated lipid metabolism, insulin resistance, mitochondrial dysfunction together with a chronic inflammatory state and cardiac apoptosis sensitization. It has been proposed that the innate immune response contributes to the onset of diabetes. Indeed, both Toll-like (TLRs) and Nucleotide-binding oligomerization domain-like (NLRs) receptors have been implicated in the pathogenesis of insulin resistance and diabetes. However, less is known regarding the contribution of these receptors to diabetic cardiac disease. Although increased cardiomyocyte (Cm) apoptosis has been described in the heart of diabetic (db) mice, the mechanisms for increased cell death remain unknown. NLR proteins have functions beyond those in the innate immune response, including the regulation of the apoptotic process. In this regard, a relationship between a subfamily of NLR, nucleotide-binding oligomerization domain-containing protein-1 (NOD1) and the caspase activation has been established. In this report we analyze the involvement of NOD1 in cardiac apoptosis related to type 2 diabetes. Methods and Results. We used a genetic mouse model of type 2 diabetes that mimics several symptoms found in type 2 diabetic patients, including obesity, hyperglycemia, hyperinsulinemia and depressed cardiac function. Our results demonstrate the expression of NOD1 in cardiac tissue, providing the first evidence of an up-regulation of NOD1-pathway in hearts of db mice. We also detect the activation of RIP2, a kinase involved in NOD1 signaling. Concomitant to these observations, chronic activation of NF-κB and apoptotic-pathways (caspase 3 and Bax over-expression and X-IAP down-regulation) were observed in hearts of db mice. At the cellular level, native Cms showed higher protein levels of NOD1 compared to wild type. As a proof of concept, both selective activation (iEDAP) and down-regulation of NOD1 (siRNA) modulate NF-κB and apoptotic-pathways in cardiac cells. In conclusion , our results indicate that cardiac NOD1 induction may participate in the process of Cms apoptosis related to diabetic cardiomyopathy and open a new paradigm linking NLRs to the cardiac damage related to type 2 diabetes.
High Cereblon Expression In Lower Risk Myelodysplastic Syndromes With 5q Deletion Is Associated With The Efficacy Of Lenalidomide
Authors: Anna T Jonasova, Jaroslav Polak, Martin Vostry, Arnost Kostecka, Radka Bokorova, Radana Neuwirtova, Magda Siskova, Miroslav Caniga, Dana Sponerova, Jaroslav Cermak, Dana Mikulenková, Jana Brezinova, Kyra Michalova, Ota Fuchs
Journal: Blood (2013)
Abstract 18369: Cholesteryl Ester Transfer Protein Activity is Associated with Oxidative Stress Markers During Acute Phase of Myocardial Infarction
Authors: Luiz Sérgio F Carvalho, Natália B Panzoldo, Eliana C de Faria, Andrei C Sposito
Journal: Circulation (2011)

Cholesteryl ester transfer protein (CETP) action enriches HDL particles with triglycerides, depletes HDL by cholesterol esters, consequently reducing size of HDL and increasing catabolism of apolipoprotein AI (Apo AI). The HDL phenotype induced by enhanced CETP activity is considered pro-atherogenic. But recent findings have linked increased CETP activity in sepsis-related acute stress to reduced inflammatory response and there is no information regarding CETP activity impact in acute coronary syndromes (ACS). We evaluated the association between CETP activity and oxidative stress and inflammatory response in patients with myocardial infaction (MI). Consecutive patients (n=38) with ST-elevation MI (STEMI) were selected from the Brasilia Heart Study for this investigation. Plasma CETP activity, HDL cholesterol, triglycerides, C-reactive protein (CRP), interleukin-2 (IL2), interleukin-10 (IL10), tumor necrosis factor α (TNFα) and isoprostane (iso-PGF 2α ) levels were measured in the first 24 hours and at the fifth day after MI onset. Patients were divided in two groups, according to CETP median (6 nmol/mL/h) at admission: M1 (CETP activity ≤ median) and M2 (CETP activity &gt; median). On admission, no difference was found between the groups in plasma HDLc (p=0.5), triglycerides (p=0.1), CRP (p=0.5), IL2 (p=0.9), IL10 (p=0.6), TNFα (p=0.2) and isoprostane (p=0.7) levels. On fifth day, both groups experienced similar reductions in CETP activity [M1: -38%(-100;30); M2: -43% (-75;8); p=0.303]. On an analysis of the change between admission and fifth day, there was a major increase in triglycerides (p&lt;0.01) in M2 group [11% (-18;32)] against M1 [3.3% (-49;16)], and also a major increase in isoprostane (p&lt;0.01) in M2 [9.1% (-30;74)] versus M1 [5.7% (-20;37)]. However, there was no significant change in HDLc (p=0.2), CRP (p=0.5), TNFα (p=0.2), IL2 (p=0.1), IL10 (p=0.9) levels between M1 and M2 groups. This is the first study that observed a marked reduction in CETP activity following STEMI. And also, the findings indicate that higher CETP activity at admission is associated with increased triglycerides and isoprostane, a marker of oxidative stress. Such information contributes for the understanding of CETP role during acute phase of ACS.
Tumor vascular targeted liposomal-bortezomib minimizes side effects and increases therapeutic activity in human neuroblastoma
Authors: Guendalina Zuccari, Andrea Milelli, Fabio Pastorino, Monica Loi, Andrea Petretto, Amelia Parise, Chiara Marchetti, Anna Minarini, Michele Cilli, Laura Emionite, Daniela Di Paolo, Chiara Brignole, Francesca Piaggio, Patrizia Perri, Vincenzo Tumiatti, Vito Pistoia, Gabriella Pagnan, Mirco Ponzoni
Journal: Journal of Controlled Release (2015)
Abstract MP49: Socioeconomic Status and Metabolic Syndrome Components in Prepubescent Colombian Children
Authors: Noel T Mueller, Mark A Pereira, Adriana Buitrago-Lopez, Diana C Rodriguez, Alvaro E Duran, Alvaro J Ruiz, Christian F Rueda-Clausen, Cristina Villa-Roel
Journal: Circulation (2013)

The association between socioeconomic status (SES) and cardiometabolic risk has been extensively described in developed societies. However, this topic has received little attention in children from developing populations undergoing nutritional transition. Using data from a population-based cross-sectional study of 1,260 children, aged 6-10 y, in Bucaramanga (Colombia), we examined the association between SES and prevalence of metabolic syndrome components (MetS) components. SES was defined according to classification of neighborhood public service fees. High mean blood pressure (≥ 90 th %ile) was determined using sex-, age-, and height-adjusted cut points. For the remaining MetS components we defined internal age- and sex-specific cut points as follows: fasting triglycerides ≥ 90 th %ile; HDL ≤ 10 th %ile; insulin resistance (HOMA-IR) ≥ 90 th %ile; and waist circumference ≥ 90 th %ile. Odds ratios (ORs) and 95% confidence intervals (CIs) for each MetS component were calculated across SES before ( Model 1 ) and after adjustment for measures of early-life nutrition ( Model 2 ) and lifestyle factors ( Model 3 )( Table ). Colombian children from households in high-SES neighborhoods had higher odds of central obesity and insulin resistance, but lower odds of high triglycerides and low HDL cholesterol than their low-SES counterparts ( Table ). ORs for high blood pressure were null. These results suggest that, in low-SES children from nutritionally transitioning populations, blood lipids may emerge as early cardiometabolic risk factors in the absence of central obesity and insulin resistance. These findings highlight the importance of evaluating MetS components individually in prepubescent children. Research is needed to confirm these associations and to understand the cultural and lifestyle factors that may differentiate cardiometabolic risk across SES in children of developing countries.
Patient response and resource management: another view of clozapine treatment of schizophrenia
Authors: W T Carpenter, R R Conley, R W Buchanan, A Breier, C A Tamminga
Journal: American Journal of Psychiatry (1995)

Issues in clozapine treatment were considered in terms of implications for resource management.A critical review of the literature on time course and pattern of response to clozapine was used to address treatment of negative symptoms, late responders, and extent of clinical benefit in ordinary settings.Superior efficacy of clozapine for partial and poor neuroleptic responders is observed in about one-half of the cases. Response is rapid once a therapeutic dose is reached, and the data do not support the proposition that some patients first respond only after 3-12 months of therapy. The cumulative benefit over several months of treatment and the broad range of symptoms involved in response are similar to those for typical neuroleptic drugs, suggesting that clozapine's superiority is based on greater effectiveness rather than a unique profile of treatment effects. Clozapine appears to be effective for secondary, but not primary, negative symptoms. Modal response is moderate, and extensive rehabilitation and clinical services are required to substantially enhance functional outcome.Many more patients merit trials with clozapine. Economic costs and adverse drug effects can be minimized by selecting patients most likely to benefit and discontinuing clozapine treatment when benefit is not observed within 2-4 months. Appropriate patients include 1) those with good responses to typical neuroleptics who experience substantial adverse effects and 2) those whose disorders respond poorly to standard neuroleptics and are defined by psychotic symptoms, thought disorder, and hostility. Treatment of primary negative symptoms is not supported by the current experimental data.
Moritz Heinrich Romberg (1795-1873)
Authors: 昭 高橋, 泰広 伊藤, 重尚 白水
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of Myocardial Strain Imaging by Echocardiography for the Early Detection of Cardiotoxicity in Patients During and After Cancer Chemotherapy
Authors: Paaladinesh Thavendiranathan, Frédéric Poulin, Ki-Dong Lim, Juan Carlos Plana, Anna Woo, Thomas H. Marwick
Journal: Journal of the American College of Cardiology (2014)
Stellate Cataract
Authors: Claus Zehetner, Nikolaos Bechrakis
Journal: New England Journal of Medicine (2013)

A 55-year-old man was referred by his general practitioner because of a progressive unilateral decrease of visual acuity over the previous 6 months. The patient reported having blunt ocular trauma from a fist punch 9 months earlier. On examination, he was noted to have a stellate-shaped axial opacification of the lens. Traumatic cataracts are caused by blunt or penetrating ocular trauma. The proposed mechanism for indirect injury is shock waves progressing through the eye along the line of concussion. Opacification of the lens may occur in the cortex or capsule and can result in the formation of a stellate-shaped or . . .
Abstract 1595: Orientation of Connexin 43 in the Inner Mitochondrial Membrane and its Role in Respiration
Authors: Kerstin Boengler, Sabine Stahlhofen, Marisol Ruiz-Meana, Elisabet Miro-Casas, David Garcia-Dorado, Gerd Heusch, Rainer Schulz
Journal: Circulation (2008)

At the sarcolemma, six connexin 43 (Cx43) proteins form hemichannels, which contribute to volume regulation. The open-probability of these hemichannels is regulated in part via the phosphorylation of Cx43 at residues predominantly present in the cytosolic carboxy-terminal domain. Cx43 is also present at the inner membrane of cardiomyocyte mitochondria. The aim of the present study was to analyze the orientation of Cx43 at the inner mitochondrial membrane, and to study whether or not the hemichannel blocker 18 α glycyrrhetinic acid (18αGA) influences mitochondrial respiration. Mitochondria were isolated from rat left ventricular myocardium and were treated with different concentrations of proteinase K, which has a broad spectrum of actions on peptide bonds. Western blot analysis was performed for marker proteins of different mitochondrial compartments (ATP synthase α: inner mitochondrial membrane (IMM), subunit in the matrix; uncoupling protein 3 (UCP3): IMM, corresponding epitope in the intermembrane spac...
The Practice of Birth Control: An Analysis of the Birth-Control Experiences of Nine Hundred Women.
Authors: Enid Charles
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The AML1/ETO(MTG8) and AML1/Evi-1 Leukemia-Associated Chimeric Oncoproteins Accumulate PEBP2β(CBFβ) in the Nucleus More Efficiently Than Wild-Type AML1
Authors: Kozo Tanaka, Tomoyuki Tanaka, Mineo Kurokawa, Yoichi Imai, Seishi Ogawa, Kinuko Mitani, Yoshio Yazaki, Hisamaru Hirai
Journal: Blood (1998)
Abstract 4397: Pitavastatin Incorporated Nanoparticle-eluting Stents Attenuate In-stent Stenosis Without Anti-healing Effects Induced by Sirolimus-eluting Stents (cypher) in Porcine Coronary Artery Model
Authors: Noriaki Tsukie, Kensuke Egashira, Kaku Nakano, Tetsuya Matoba, Kenji Sunagawa
Journal: Circulation (2009)
Manual of Physical Diagnosis with Special Consideration of the Heart and Lungs
Authors: George Charles Coe, Ellis Benjamin Freilich
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal