tbuckley/cabot-search huggingface dataset:
National Trends in Heart Failure Hospitalization and Readmissions Associated With Policy Changes
Authors: Toshiki Kuno, Alexandros Briasoulis, Yusuke Tsugawa
Journal: JAMA Cardiology (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Isatuximab, carfilzomib, lenalidomide, and dexamethasone (Isa-KRd) in front-line treatment of high-risk multiple myeloma: interim analysis of the GMMG-CONCEPT trial
Authors: Lisa B. Leypoldt, Britta Besemer, Anne Marie Asemissen, Mathias Hänel, Igor Wolfgang Blau, Martin Görner, Yon-Dschun Ko, Hans Christian Reinhardt, Peter Staib, Christoph Mann, Raphael Lutz, Markus Munder, Ullrich Graeven, Rudolf Peceny, Hans Salwender, Anna Jauch, Manola Zago, Axel Benner, Diana Tichy, Carsten Bokemeyer, Hartmut Goldschmidt, Katja C. Weisel
Journal: Leukemia (2021)
Manual of Practical Physiology.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Non-HLA antibodies targeting angiotensin II Type 1 receptor and endothelin-1 Type A receptors induce endothelial injury via β2-arrestin link to mTOR pathway
Authors: Rusan Ali Catar, Oskar Wischnewski, Lei Chen, Harald Heidecke, Claudia Rutz, Ralf Schülein, Duska Dragun, Aurélie Philippe, Angelika Kusch
Journal: Kidney International (2021)
A Rare Case of Adenovirus Interstitial Nephritis and AMR Within Two Weeks of Kidney Transplant
Authors: Maliha Ahmed, Mohammed R. Karim, Hae Yoon Grace Choung
Journal: Journal of the American Society of Nephrology (2021)

Journal of the American Society of Nephrology 32(10S):p 646-647, October 2021. | DOI: 10.1681/ASN.20213210S1646c
The false hope of current approaches to explainable artificial intelligence in health care
Authors: Marzyeh Ghassemi, Luke Oakden-Rayner, Andrew L Beam
Journal: The Lancet Digital Health (2021)

The black-box nature of current artificial intelligence (AI) has caused some to question whether AI must be explainable to be used in high-stakes scenarios such as medicine. It has been argued that explainable AI will engender trust with the health-care workforce, provide transparency into the AI decision making process, and potentially mitigate various kinds of bias. In this Viewpoint, we argue that this argument represents a false hope for explainable AI and that current explainability methods are unlikely to achieve these goals for patient-level decision support. We provide an overview of current explainability techniques and highlight how various failure cases can cause problems for decision making for individual patients. In the absence of suitable explainability methods, we advocate for rigorous internal and external validation of AI models as a more direct means of achieving the goals often associated with explainability, and we caution against having explainability be a requirement for clinically deployed models.
Is epiploic fat the dermal fat of the intestine?
Authors: Yasuhiro Onogi, Siegfried Ussar
Journal: Gut (2021)

White adipose tissue is the primary site of energy storage to maintain metabolic function of the organism at times of starvation. Moreover, a multitude of hormones, cytokines and other bioactive molecules secreted from adipose tissue regulate key aspects of systemic metabolism.1 2 In mammals adipose is organised in multiple depots throughout the body differing in size, developmental origin and function.1 2 These depots are divided into subcutaneous and visceral adipose tissues. Although individual depots within these categories differ between species, for example, humans and mice, excessive accumulation of fat in visceral adipose associates with impaired insulin sensitivity and the development of the metabolic syndrome, whereas increase in subcutaneous adipose mass does not show this association.1 3 Given the central role of adipose tissue in the regulation of systemic lipid and glucose homoeostasis and the ever-increasing details known on cellular composition and function of adipocytes within the large adipose depots, it is surprising that some adipose tissues remain barely studied.

In GUT , Krieg and colleagues perform a detailed multi-omics comparison and characterisation of human epiploic fat with subcutaneous, omental and mesenteric fat of insulin sensitive and insulin resistant subjects. Epiploic fat is part of visceral adipose tissue located along the colon …
Abstract 10906: Active Cardiac Targeting Delivery of Erythropoietin by Liposomes Repairs Infarcted Myocardium Through Activation of Prosurvival Signals and Angiogenesis in Rabbits
Authors: Yoshihisa Yamada, Eishun Horibe, Hiroyuki Kobayashi, Masamitsu Iwasa, Hiroaki Ushikoshi, Takuma Aoyama, Kazuhiko Nishigaki, Genzou Takemura, Takako Fujiwara, Hisayoshi Fujiwara, Shinya Minatoguchi
Journal: Circulation (2012)

Backgrounds: Erythropoietin (EPO) exerts cardioprotection but causes side effects such as polycytemia. Therefore, cardiac targeting delivery system of EPO without side effects is required. We inves...
TCT-59 Comprehensive Coronary Plaque Assessment Software: OCTOPUS-v2
Authors: Juhwan Lee, Yazan Gharaibeh, Vladislav Zimin, Gabriel Tensol Rodrigues Pereira, Luis Augusto Palma Dallan, Justin Kim, Ammar Hoori, Hiram Bezerra, David Wilson
Journal: Journal of the American College of Cardiology (2021)
TCT-347 Valve-in-Valve Transcatheter Aortic Valve Replacement Versus Redo Surgical Aortic Valve Replacement for Failed Surgical Aortic Bioprostheses: A Systematic Review and Meta-Analysis
Authors: Matthias Raschpichler, Suzanne De Waha-Thiele, David Holzhey, Guido Schwarzer, Danon Kaewkes, Paul Bräuchle, Danny Dvir, Raj Makkar, Gorav Ailawadi, Mohamed Abdel-Wahab, Holger Thiele, Michael Borger
Journal: Journal of the American College of Cardiology (2021)
The impact of COVID-19 on community antibiotic use in Canada: an ecological study
Authors: Braden D. Knight, Jayson Shurgold, Glenys Smith, Derek R. MacFadden, Kevin L. Schwartz, Nick Daneman, Denise Gravel Tropper, James Brooks
Journal: Clinical Microbiology and Infection (2021)

The COVID-19 pandemic has had an effect on the incidence of infectious diseases and medical care. This study aimed to describe the impact of the COVID-19 pandemic on community-level antibiotic use.Using national antibiotic dispensing data from IQVIA's CompuScript database, this ecological study investigated antibiotic dispensing through community retail pharmacies in Canada from November 2014 to October 2020. Analyses were stratified by age, sex, prescription origin and approximate indication.Adjusting for seasonality, the national rate of antibiotic dispensing in Canada decreased by 26.5% (50.4 to 37.0 average prescriptions per 1000 inhabitants) during the first 8 months of the Canadian COVID-19 period (March to October 2020), compared with the pre-COVID-19 period. Prescribing rates in children ≤18 years decreased from 43.7 to 12.2 prescriptions per 1000 inhabitants in males (-72%) and from 46.8 to 14.9 prescriptions per 1000 inhabitants in females (-68%) in April 2020. Rates in adults ≥65 decreased from 74.9 to 48.8 prescriptions per 1000 inhabitants in males (-35%) and from 91.7 to 61.3 prescriptions per 1000 inhabitants in females (-33%) in May 2020. Antibiotic prescriptions from family physicians experienced a greater decrease than from surgeons and infectious disease physicians. Prescribing rates for antibiotics for respiratory indications decreased by 56% in May 2020 (29.2 to 12.8 prescriptions per 1000 inhabitants), compared with prescribing rates for urinary tract infections (9.4 to 7.8 prescriptions per 1000 inhabitants; -17%) and skin and soft tissue infections (6.4 to 5.2 prescriptions per 1000 inhabitants; -19%).The first 8 months of the COVID-19 pandemic reduced community antibiotic dispensing by 26.5% in Canada, compared with the marginal decrease of 3% in antibiotic consumption between 2015 and 2019. Further research is needed to understand the implications and long-term effects of the observed reductions on antibiotic use on antibiotic resistance in Canada.
Remission of Type 2 Diabetes Following a Short-term Intensive Intervention With Insulin Glargine, Sitagliptin, and Metformin: Results of an Open-label Randomized Parallel-Design Trial
Authors: Natalia McInnes, Stephanie Hall, Irene Hramiak, Ronald J. Sigal, Ronald Goldenberg, Nikhil Gupta, Remi Rabasa-Lhoret, Manoela Braga, Vincent Woo, Farah Sultan, Rose Otto, Ada Smith, Diana Sherifali, Yan Yun Liu, Hertzel C. Gerstein
Journal: Diabetes Care (2021)

The aim of the study was to evaluate remission of type 2 diabetes following a short-term intervention with insulin glargine, sitagliptin/metformin, and lifestyle approaches.In this open multicenter trial, 102 patients with type 2 diabetes were randomized to 1) a 12-week intervention with sitagliptin/metformin, insulin glargine, and lifestyle therapy or 2) control group. Participants with HbA1c <7.3% (<56 mmol/mol) at 12 weeks were asked to stop diabetes medications and were followed for evidence of relapse over 52 weeks. Diabetes relapse criteria included HbA1c ≥6.5% (≥48 mmol/mol), ≥50% of capillary glucose readings >10 mmol/L over 1 week, and reinitiation of diabetes medications with or without abnormal fasting plasma glucose (FPG) or 2-h plasma glucose on an oral glucose tolerance test (OGTT). Time-to-relapse analysis was conducted to compare the treatment groups with (primary analysis) and without (supplementary analysis) FPG/OGTT relapse criteria.With the FPG/OGTT relapse criteria included, the hazard ratio (HR) of relapse was 0.72 (95% CI 0.47-1.10) in the intervention group compared with the control group (primary analysis), and the number of participants remaining in remission was not significantly different between treatment groups at 24, 36, 48, and 64 weeks. In the supplementary analyses without these criteria, HR of relapse was 0.60 (95% CI 0.39-0.95), and the number of participants remaining in remission was significantly higher (26 vs. 10%) in the intervention group at 36 weeks.Although our primary outcome was not statistically significant, the tested approach deserves further study with further optimization of its components.
Ultrasmall Fe-doped carbon dots nanozymes for photoenhanced antibacterial therapy and wound healing
Authors: Yunhang Liu, Bolong Xu, Mingzhu Lu, Shanshan Li, Juan Guo, Fangzhou Chen, Xiaolu Xiong, Zhe Yin, Huiyu Liu, Dongsheng Zhou
Journal: Bioactive Materials (2021)

Pathogenic bacteria pose a devastating threat to public health. However, because of the growing bacterial antibiotic resistance, there is an urgent need to develop alternative antibacterial strategies to the established antibiotics. Herein, iron-doped carbon dots (Fe-CDs, ∼3 nm) nanozymes with excellent photothermal conversion and photoenhanced enzyme-like properties are developed through a facile one-pot pyrolysis approach for synergistic efficient antibacterial therapy and wound healing. In particular, Fe doping endows CDs with photoenhanced peroxidase (POD)-like activity, which lead to the generation of heat and reactive oxygen species (ROS) for Gram-positive and Gram-negative bacteria killing. This study demonstrates Fe-CDs have significant wound healing efficiency of Fe-CDs by preventing infection, promoting fibroblast proliferation, angiogenesis, and collagen deposition. Furthermore, the ultrasmall size of Fe-CDs possesses good biocompatibility favoring clinical translation. We believe that the nanozyme-mediated therapeutic platform presented here is expected to show promising applications in antibacterial.
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Authors: Mathias Ried-Larsen, Martin Gillies Rasmussen, Anders Grøntved
Journal: JAMA Internal Medicine (2021)

Nareg H. Roubinian, MD; Jennifer R. Dusendang, MPH; Dustin G. Mark, MD; David R. Vinson, MD; Vincent X. Liu, MD; Julie A. Schmittdiel, PhD; Ashok P. Pai, MD
Pirtobrutinib, A Next Generation, Highly Selective, Non-Covalent BTK Inhibitor in Previously Treated Mantle Cell Lymphoma: Updated Results from the Phase 1/2 BRUIN Study
Authors: Michael Wang, Nirav N. Shah, Alvaro J. Alencar, James N. Gerson, Manish R. Patel, Bita Fakhri, Wojciech Jurczak, Xuan Ni Tan, Katharine Lewis, Timothy S. Fenske, Catherine C. Coombs, Ian W. Flinn, David John Lewis, Steven Le Gouill, M. Lia Palomba, Jennifer A. Woyach, John M. Pagel, Nicole Lamanna, Jonathon B. Cohen, Minal A. Barve, Paolo Ghia, Toby A. Eyre, Pier Luigi Luigi Zinzani, Chaitra S. Ujjani, Youngil Koh, Koji Izutsu, Ewa Lech-Marańda, Constantine S. Tam, Suchitra Sundaram, Ming Yin, Binoj Nair, Minna Balbas, Donald Tsai, Anthony R. Mato, Chan Yoon Cheah
Journal: Blood (2021)
TCT-495 Prognostic Value of Global Quantitative Flow Ratio in Chronic Ischemic Heart Disease: A Multicenter Study
Authors: Carlos Cortes, Pablo Fernández Corredoira, Alfonso Freites Esteves, Octavi Jímenez, Fernando Rivero, Ainhoa Perez Guerrero, Luis Cerdán, Juan Sánchez-Rubio, Georgina Fuertes Ferre, Maria-Cruz Ferrer Gracia, Gabriel Galache, Fernando Lozano, Armando Perez de Prado, Fernando Alfonso, Maria Rosario Ortas-Nadal, Jose Antonio Diarte de Miguel
Journal: Journal of the American College of Cardiology (2021)
TCT-432 Greater Splanchnic Nerve Ablation in Chronic Heart Failure: Preserved Versus Reduced Left Ventricular Ejection Fraction
Authors: Vivek Reddy, Horst Sievert, Teona Zirakashvili, Filip Málek, Marat Fudim, Zoar Engelman, Petr Neuzil, Tamaz Shaburishvili, Sanjiv Shah
Journal: Journal of the American College of Cardiology (2021)
TCT-313 Complete Revascularization in Impella-Supported Infarct-Related Cardiogenic Shock Patients Is Associated With Improved Mortality
Authors: Andreas Schafer, Ralf Westenfeld, Jan-Thorben Sieweke, Andreas Zietzer, Julian Wiora, Giulia Masiero, Carolina Sanchez Martinez, Giuseppe Tarantini, Nikos Werner
Journal: Journal of the American College of Cardiology (2021)
TCT-54 Trends in Utilization and Outcomes Associated With Use of Transcatheter Aortic Valve Replacement According to Frailty
Authors: Aaqib Malik, Jayakumar Sreenivasan, Syed Zaid, Wilbert Aronow, Alexandros Briasoulis, Syed Haidry, Howard Cooper, Ryan Kaple, Gilbert Tang, Hasan Ahmad
Journal: Journal of the American College of Cardiology (2021)
Soluble VE-cadherin: not just a marker of endothelial permeability
Authors: Shi Qi Li, Ying Ni Lin, Qing Yun Li
Journal: European Respiratory Journal (2021)

<b>Serum soluble VE-cadherin holds a promise as a marker of endothelial permeability; further investigations are still needed to confirm the sensitivity and specificity, and extend the existing findings</b>https://bit.ly/2WujSCc
Screening HLA-A-restricted T cell epitopes of SARS-CoV-2 and the induction of CD8+ T cell responses in HLA-A transgenic mice
Authors: Xiaoxiao Jin, Yan Ding, Shihui Sun, Xinyi Wang, Zining Zhou, Xiaotao Liu, Miaomiao Li, Xian Chen, Anran Shen, Yandan Wu, Bicheng Liu, Jianqiong Zhang, Jian Li, Yi Yang, Haibo Qiu, Chuanlai Shen, Yuxian He, Guangyu Zhao
Journal: Cellular and Molecular Immunology (2021)

Since severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-specific T cells have been found to play essential roles in host immune protection and pathology in patients with coronavirus disease 2019 (COVID-19), this study focused on the functional validation of T cell epitopes and the development of vaccines that induce specific T cell responses. A total of 120 CD8+ T cell epitopes from the E, M, N, S, and RdRp proteins were functionally validated. Among these, 110, 15, 6, 14, and 12 epitopes were highly homologous with SARS-CoV, OC43, NL63, HKU1, and 229E, respectively; in addition, four epitopes from the S protein displayed one amino acid that was distinct from the current SARS-CoV-2 variants. Then, 31 epitopes restricted by the HLA-A2 molecule were used to generate peptide cocktail vaccines in combination with Poly(I:C), R848 or poly (lactic-co-glycolic acid) nanoparticles, and these vaccines elicited robust and specific CD8+ T cell responses in HLA-A2/DR1 transgenic mice as well as wild-type mice. In contrast to previous research, this study established a modified DC-peptide-PBL cell coculture system using healthy donor PBMCs to validate the in silico predicted epitopes, provided an epitope library restricted by nine of the most prevalent HLA-A allotypes covering broad Asian populations, and identified the HLA-A restrictions of these validated epitopes using competitive peptide binding experiments with HMy2.CIR cell lines expressing the indicated HLA-A allotype, which initially confirmed the in vivo feasibility of 9- or 10-mer peptide cocktail vaccines against SARS-CoV-2. These data will facilitate the design and development of vaccines that induce antiviral CD8+ T cell responses in COVID-19 patients.
TCT-424 Sirolimus Versus Paclitaxel Drug-Eluting Balloon Treatment for Patients With Vasculogenic Erectile Dysfunction
Authors: Debora Russo, Daniela Benedetto, Gianluca Massaro, Giulio Russo, Dalgisio Lecis, Alessio Di Landro, Massimiliano Macrini, Enrica Mariano, Linda Cota, Saverio Muscoli, Giuseppe Sangiorgi
Journal: Journal of the American College of Cardiology (2021)
TCT-410 Computational Flow Dynamic Simulation of Transcatheter Mitral Valve Implantation Indicates That Multiple Anatomical Factors Contribute to Postprocedural Outflow Tract Obstruction
Authors: James Otton, Chin Neng Leong, Amr Al Abed, Yousef Alharbi, Susann Beier, Socrates Dokos
Journal: Journal of the American College of Cardiology (2021)
Haste makes waste: A critical review of docking‐based virtual screening in drug repurposing for SARS‐CoV‐2 main protease (M‐pro) inhibition
Authors: Guillem Macip, Pol Garcia‐Segura, Júlia Mestres‐Truyol, Bryan Saldivar‐Espinoza, María José Ojeda‐Montes, Aleix Gimeno, Adrià Cereto‐Massagué, Santiago Garcia‐Vallvé, Gerard Pujadas
Journal: Medicinal Research Reviews (2021)

This review makes a critical evaluation of 61 peer-reviewed manuscripts that use a docking step in a virtual screening (VS) protocol to predict SARS-CoV-2 M-pro (M-pro) inhibitors in approved or investigational drugs. Various manuscripts predict different compounds, even when they use a similar initial dataset and methodology, and most of them do not validate their methodology or results. In addition, a set of known 150 SARS-CoV-2 M-pro inhibitors extracted from the literature and a second set of 81 M-pro inhibitors and 113 inactive compounds obtained from the COVID Moonshot project were used to evaluate the reliability of using docking scores as feasible predictors of the potency of a SARS-CoV-2 M-pro inhibitor. Using two SARS-CoV-2 M-pro structures and five protein-ligand docking programs, we proved that the correlation between the pIC50 and docking scores is not good. Neither was any correlation found between the pIC50 and the ∆G calculated with an MM-GBSA method. When a group of experimentally known inactive compounds was added, neither the docking scores or the ∆G were able to distinguish between compounds with or without M-pro experimental inhibitory activity. Performances improved when covalent and noncovalent inhibitors were treated separately, but were not good enough to fully support using a docking score as a cutoff value for selecting new putative M-pro inhibitors or predicting the relative bioactivity of a compound by comparison with a reference compound. The two sets of known SARS-CoV-2 M-pro inhibitors presented here could be used for validating future VS protocols which aim to predict M-pro inhibitors.
Quantitative Biochemical Differences between Tumor and Host as a Basis for Cancer Chemotherapy
Authors: Daniel M. Shapiro, L. S. Dietrich, Maurice E. Shils, A. Atti, E. Borries, R. Fugmann, V. Muller, P. Hayworth, E. Zanar
Journal: Cancer Research (1956)

6,7-Dimethyl-9-hydroxyethyl-isoalloxazine (U-2113), an analog of riboflavin, was observed to have very weak carcinostatic action when used alone against the adenocarcinoma 755 grown in either sex of the C57BL mouse.

Chemotherapeutic trials employing 8-azaguanine and testosterone in double combination, or with the addition of either deoxypyridoxine or U-2113 to give a triple combination, produced no greater carcinostatic effect than could be produced by 8-azaguanine alone under the particular conditions of these experiments. However, the combination of all four of these compounds produced a significant increase in carcinostatic action.

The increase in carcinostasis resulting from the combining of 8-azaguanine, testosterone, U-2113, and deoxypyridoxine was achieved with doses of U-2113 and deoxypyridoxine which by themselves would be ineffective in producing toxic effects on either tumor or host tissue.

The riboflavin analog, U-2113, does not antagonize the flavo-enzyme, xanthine oxidase, in the 755 tumor.

Total riboflavin, flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN), and free riboflavin were measured in the adenocarcinoma and host tissues of the mice (C57). Riboflavin was found to be significantly lower in tumor than any normal tissue analyzed except skeletal muscle. The ratio of FAD to total riboflavin of tumor was very similar to that of other tissues, while the ratio of FMN to total riboflavin of various normal tissues covered a wide range which included tumor.
In patients hospitalized for COVID-19, tocilizumab reduces mortality at 28 d
Authors: Carson K.L. Lo, Zain Chagla
Journal: Annals of Internal Medicine (2021)

WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group; Shankar-Hari M, Vale CL, Godolphin PJ, et al. Association between administration of IL-6 antagonists and mortality among patients hospitalized for COVID-19: a meta-analysis. JAMA. 2021;326:499-518. 34228774.
When I use a word . . . . The efficiency paradox
Authors: Jeffrey K Aronson
Journal: BMJ (2021)

The efficiency paradox in healthcare arises from the mistaken belief that maximizing the use of resources necessarily improves overall efficiency. A recent study in patients with arthropathies or lupus suggests that attempting to improve efficiency by using telemedicine may in fact reduce the efficient delivery of healthcare for some patients, and even for some doctors.