tbuckley/cabot-search huggingface dataset:
The role and application of small extracellular vesicles in gastric cancer
Authors: Hao Wu, Mengdi Fu, Jin Liu, Wei Chong, Zhen Fang, Fengying Du, Yang Liu, Liang Shang, Leping Li
Journal: Molecular Cancer (2021)

Abstract Gastric cancer (GC) is a common tumour that affects humans worldwide, is highly malignant and has a poor prognosis. Small extracellular vesicles (sEVs), especially exosomes, are nanoscale vesicles released by various cells that deliver bioactive molecules to recipient cells, affecting their biological characteristics, changing the tumour microenvironment and producing long-distance effects. In recent years, many studies have clarified the mechanisms by which sEVs function with regard to the initiation, progression, angiogenesis, metastasis and chemoresistance of GC. These molecules can function as mediators of cell-cell communication in the tumour microenvironment and might affect the efficacy of immunotherapy. Due to their unique physiochemical characteristics, sEVs show potential as effective antitumour vaccines as well as drug carriers. In this review, we summarize the roles of sEVs in GC and highlight the clinical application prospects in the future.
Bacterial infections adversely influence the risk of decompensation and survival in compensated cirrhosis
Authors: Càndid Villanueva, Agustín Albillos, Joan Genescà, Joan C. Garcia-Pagan, Anna Brujats, José L. Calleja, Carles Aracil, Rafael Bañares, Rosa M. Morillas, María Poca, Beatriz Peñas, Salvador Augustin, Juan G. Abraldes, Edilmar Alvarado, Ferran Torres, Jaume Bosch
Journal: Journal of Hepatology (2021)
The combination of carboxy‐terminal propeptide of procollagen type I blood levels and late gadolinium enhancement at cardiac magnetic resonance provides additional prognostic information in idiopathic dilated cardiomyopathy – A multilevel assessment of myocardial fibrosis in dilated cardiomyopathy
Authors: Anne G. Raafs, Job A.J. Verdonschot, Michiel T.H.M. Henkens, Bouke P. Adriaans, Ping Wang, Kasper Derks, Myrurgia A. Abdul Hamid, Christian Knackstedt, Vanessa P.M. van Empel, Javier Díez, Hans‐Peter Brunner‐La Rocca, Han G. Brunner, Arantxa González, Sebastiaan C.A.M. Bekkers, Stephane R.B. Heymans, Mark R. Hazebroek
Journal: European Journal of Heart Failure (2021)

Abstract Aims To determine the prognostic value of multilevel assessment of fibrosis in dilated cardiomyopathy (DCM) patients. Methods and results We quantified fibrosis in 209 DCM patients at three levels: (i) non‐invasive late gadolinium enhancement (LGE) at cardiac magnetic resonance (CMR); (ii) blood biomarkers [amino‐terminal propeptide of procollagen type III (PIIINP) and carboxy‐terminal propeptide of procollagen type I (PICP)], (iii) invasive endomyocardial biopsy (EMB) (collagen volume fraction, CVF). Both LGE and elevated blood PICP levels, but neither PIIINP nor CVF predicted a worse outcome defined as death, heart transplantation, heart failure hospitalization, or life‐threatening arrhythmias, after adjusting for known clinical predictors [adjusted hazard ratios: LGE 3.54, 95% confidence interval (CI) 1.90–6.60; P &lt; 0.001 and PICP 1.02, 95% CI 1.01–1.03; P = 0.001]. The combination of LGE and PICP provided the highest prognostic benefit in prediction (likelihood ratio test P = 0.007) and reclassification (net reclassification index: 0.28, P = 0.02; and integrated discrimination improvement index: 0.139, P = 0.01) when added to the clinical prediction model. Moreover, patients with a combination of LGE and elevated PICP (LGE+/PICP+) had the worst prognosis (log‐rank P &lt; 0.001). RNA‐sequencing and gene enrichment analysis of EMB showed an increased expression of pro‐fibrotic and pro‐inflammatory pathways in patients with high levels of fibrosis (LGE+/PICP+) compared to patients with low levels of fibrosis (LGE‐/PICP‐). This would suggest the validity of myocardial fibrosis detection by LGE and PICP, as the subsequent generated fibrotic risk profiles are associated with distinct cardiac transcriptomic profiles. Conclusion The combination of myocardial fibrosis at CMR and circulating PICP levels provides additive prognostic value accompanied by a pro‐fibrotic and pro‐inflammatory transcriptomic profile in DCM patients with LGE and elevated PICP.
Electrical Stimulator Can Improve MS-Related Walking Problems
Authors: Rebecca Voelker
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LIVE PROCEDURE FOR THE TREATMENT OF ISCHEMIC HEART FAILURE - CURRENT SHORT AND MID-TERM OUTCOMES
Authors: Paulo Neves, Thasee Pillay, Lon Annest, Kevin Van Bladel, Erhard Kaiser, Andrew Wechsler, Patrick Klein, Thorsten Hanke, Ralph Stephan Von Bardeleben
Journal: Journal of the American College of Cardiology (2021)
A HYBRID APPROACH TO AUTOMATE QUANTITATIVE CORONARY ANGIOGRAPHY VIA DEEP LEARNING
Authors: Keisuke Yasumura, Hiroki Ueyama, Yuliya Vengrenyuk, Javier Oliván Bescós, Bertan Hallacoglu, Iris ter Horst, Roxana Mehran, Samin Sharma, Annapoorna Kini
Journal: Journal of the American College of Cardiology (2021)
SEX-BASED OUTCOMES OF SURGICAL MYECTOMY FOR HYPERTROPHIC CARDIOMYOPATHY
Authors: Mohammed Osman, Moinuddin Syed, Khansa Osman, Brijesh Patel, Mohammad Akram Kawsara, Babikir Kheiri, Sudarshan Balla, Lawrence Wei, Christopher Bianco
Journal: Journal of the American College of Cardiology (2021)
Identification of Novel Fusion Genes and Characterization of Transcriptome Features in T-Cell Acute Lymphoblastic Leukemia
Authors: Bing Chen, Jiang Lu, Meng-Ling Zhong, Jian-Feng Li, Ben-Shang Li, Li-Jun Peng, Yu-Ting Dai, Wei-Na Zhang, Su-Ning Chen, Jianda Hu, De-pei Wu, Zhu Chen, Jing-Yan Tang, Jin-yan Huang, Jian-Qing Mi, Sai-Juan Chen
Journal: Blood (2017)
Abstract 16147: National Survey With Over 800 000 Adults Reveals State-Wide Variation and High Level of Uncontrolled Hypertension in India
Authors: Ming Kei Chung, Kajal Claypool, Chirag Patel
Journal: Circulation (2019)

Introduction: Adequate control of hypertension (HTN) could prevent or delay the onset of cardiovascular disease and lower the burden of health care system. In India, prevalence of HTN has been incr...
INCIDENTALLY DIAGNOSED LARGE SACCULAR AORTIC ANEURYSM IN A PATIENT WITH REMOTE HISTORY OF TRAUMA
Authors: Biren D. Patel, Kinjal Patel, Bhavik Patel, Kalpeshkumar Shah, Nirmal Guragai, Meherwan Joshi, Fayez Shamoon
Journal: Journal of the American College of Cardiology (2021)
NATIONWIDE TRENDS AND OUTCOMES OF PERCUTANEOUS CORONARY INTERVENTIONS FOLLOWING DIAGNOSTIC ANGIOGRAPHY PERFORMED BY NON-INTERVENTIONAL CARDIOLOGIST VERSUS INTERVENTIONALISTS: INSIGHTS FROM THE CATHPCI REGISTRY
Authors: Fabio V. Lima, Pratik Manandhar, Daniel Wojdyla, Tracy Wang, Herbert Aronow, Vishnu Kadiyala, Elizabeth Weissler, Nidhi Madan, Ian Gilchrist, Cindy Grines, J. Abbott
Journal: Journal of the American College of Cardiology (2021)
Depression and Incident Cardiovascular Disease
Authors: Ibrahim El-Battrawy, Michael Behnes, Ibrahim Akin
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CLINICAL OUTCOMES AND PREDICTORS OF COVID-19 PATIENTS WITH TROPONIN ELEVATION AND CONCOMITANT RENAL DYSFUNCTION
Authors: Brian Case, Brian Forrestal, Charan Yerasi, Chava Chezar-Azerrad, Corey Shea, Hank Rappaport, Giorgio Medranda, Cheng Zhang, Lowell Satler, Itsik Ben-Dor, Hayder Hashim, Toby Rogers, Ron Waksman
Journal: Journal of the American College of Cardiology (2021)
Abstract 15746: Intrinsic Cardiomyocyte Mitochondrial Defects Underlie Cardiac Dysfunction and Heart Failure Risk Associated With Hypoplastic Left Heart Syndrome
Authors: Xinxiu Xu, Tuantuan Tan, Jiuann-Huey Ivy Lin, Phillips Adams, Xiaoqin Liu, Feinstein Timothy N, Omar Khalifa, PorterGeorge A, Sruti S. Shiva, Cecilia Lo
Journal: Circulation (2018)

Introduction: Hypoplastic left heart syndrome (HLHS) is a complex congenital heart disease with high morbidity/mortality and high risk of heart failure. Based on findings from the Ohia HLHS mouse m...
Abstract 12910: Pulmonary Effective Arterial Elastance Independently Predicts Mortality in Pulmonary Arterial Hypertension
Authors: Sthuthi David, Kenneth Bilchick, Jamie Kennedy, Khadijah Breathett, Alex Parker, Jeremy Mazurek, Hunter Mwansa, Andrew Mihalek, Sula Mazimba
Journal: Circulation (2018)

Introduction: Right ventricular (RV) function is a key determinant of mortality in pulmonary arterial hypertension (PAH). Pulmonary effective arterial elastance (PAE) is a hemodynamic marker of tot...
Association of Sex With Adolescent Soccer Concussion Incidence and Characteristics
Authors: Abigail C. Bretzin, Tracey Covassin, Douglas J. Wiebe, William Stewart
Journal: JAMA Network Open (2021)

Because of the negative consequences of concussion, considerable research efforts have been directed toward understanding the risk factors for sport-related concussion (SRC) and its outcomes to better inform strategies for risk reduction. Girls are suggested to have an increased risk of concussion, warranting exploration into sex-dependent variations in concussion presentation and management, with the potential that this information might inform sex-specific rules directed toward risk reduction within sports.
Integrin α2β1 regulates collagen I tethering to modulate hyperresponsiveness in reactive airway disease models
Authors: Sean Liu, Uyen Ngo, Xin-Zi Tang, Xin Ren, Wenli Qiu, Xiaozhu Huang, William DeGrado, Christopher D.C. Allen, Hyunil Jo, Dean Sheppard, Aparna B. Sundaram
Journal: Journal of Clinical Investigation (2021)

Severe asthma remains challenging to manage and has limited treatment options. We have previously shown that targeting smooth muscle integrin α5β1 interaction with fibronectin can mitigate the effects of airway hyperresponsiveness by impairing force transmission. In this study, we show that another member of the integrin superfamily, integrin α2β1, is present in airway smooth muscle and capable of regulating force transmission via cellular tethering to the matrix protein collagen I and, to a lesser degree, laminin-111. The addition of an inhibitor of integrin α2β1 impaired IL-13–enhanced contraction in mouse tracheal rings and human bronchial rings and abrogated the exaggerated bronchoconstriction induced by allergen sensitization and challenge. We confirmed that this effect was not due to alterations in classic intracellular myosin light chain phosphorylation regulating muscle shortening. Although IL-13 did not affect surface expression of α2β1, it did increase α2β1-mediated adhesion and the level of expression of an activation-specific epitope on the β1 subunit. We developed a method to simultaneously quantify airway narrowing and muscle shortening using 2-photon microscopy and demonstrated that inhibition of α2β1 mitigated IL-13–enhanced airway narrowing without altering muscle shortening by impairing the tethering of muscle to the surrounding matrix. Our data identified cell matrix tethering as an attractive therapeutic target to mitigate the severity of airway contraction in asthma.
Evaluating the transcriptional fidelity of cancer models
Authors: Da Peng, Rachel Gleyzer, Wen-Hsin Tai, Pavithra Kumar, Qin Bian, Bradley Isaacs, Edroaldo Lummertz da Rocha, Stephanie Cai, Kathleen DiNapoli, Franklin W. Huang, Patrick Cahan
Journal: Genome Medicine (2021)

Abstract Background Cancer researchers use cell lines, patient-derived xenografts, engineered mice, and tumoroids as models to investigate tumor biology and to identify therapies. The generalizability and power of a model derive from the fidelity with which it represents the tumor type under investigation; however, the extent to which this is true is often unclear. The preponderance of models and the ability to readily generate new ones has created a demand for tools that can measure the extent and ways in which cancer models resemble or diverge from native tumors. Methods We developed a machine learning-based computational tool, CancerCellNet, that measures the similarity of cancer models to 22 naturally occurring tumor types and 36 subtypes, in a platform and species agnostic manner. We applied this tool to 657 cancer cell lines, 415 patient-derived xenografts, 26 distinct genetically engineered mouse models, and 131 tumoroids. We validated CancerCellNet by application to independent data, and we tested several predictions with immunofluorescence. Results We have documented the cancer models with the greatest transcriptional fidelity to natural tumors, we have identified cancers underserved by adequate models, and we have found models with annotations that do not match their classification. By comparing models across modalities, we report that, on average, genetically engineered mice and tumoroids have higher transcriptional fidelity than patient-derived xenografts and cell lines in four out of five tumor types. However, several patient-derived xenografts and tumoroids have classification scores that are on par with native tumors, highlighting both their potential as faithful model classes and their heterogeneity. Conclusions CancerCellNet enables the rapid assessment of transcriptional fidelity of tumor models. We have made CancerCellNet available as a freely downloadable R package ( https://github.com/pcahan1/cancerCellNet ) and as a web application ( http://www.cahanlab.org/resources/cancerCellNet_web ) that can be applied to new cancer models that allows for direct comparison to the cancer models evaluated here.
CLINICAL APPLICATION OF A SOLUTION SET OF CLINICAL DECISION SUPPORT TOOLS IMPROVES QUALITY OF CARE IN HYPERLIPIDEMIA PATIENTS: INTERIM RESULTS FROM THE STATEWIDE FLORIDA CARDIOVASCULAR QUALITY NETWORK
Authors: A. Allen Seals, Dean Bramlet, Paul Ziajka, Jane Kienle, Debra Freidrich, Benedict Maniscalco, Sandra Kreul, Jonathan Fialkow, Lisa Davis, Richard Torricelli, DeEtta DeBault, Kim Seals
Journal: Journal of the American College of Cardiology (2021)
Optimism with Caution: Elexacaftor–Tezacaftor–Ivacaftor in Patients with Advanced Pulmonary Disease
Authors: Stephanie L. Kuek, Sarath C. Ranganathan, Joanne Harrison, Philip J. Robinson, Shivanthan Shanthikumar
Journal: American Journal of Respiratory and Critical Care Medicine (2021)

The primary limitation of our study is its cross-sectional design, which did not allow us to measure temporal changes in outcome.Participants with preexisting respiratory conditions are more likely to remember adverse events than participants without these conditions, which may lead to recall bias and overestimation of the risk of adverse events.Future studies would benefit from a cohort design, which would overcome these limitations.Nonetheless, the chance of participants without respiratory conditions not recalling these events is partially mitigated by the fact that the 2019-2020 bushfire was a major natural disaster and the adverse effects surveyed were relatively uncommon.In conclusion, smoke exposure was significantly associated with adverse health effects during the Australian bushfire season in 2019/2020 not only among people with respiratory conditions but also among healthy people.Surprisingly, older age (65 yr and above) was associated with a significantly lower risk of adverse health effects.Our data suggest older people may be more cautious and less mobile in outdoor settings than younger people during bushfires.Younger people (,65 yr) may benefit from public health messaging about outdoor air avoidance and respirator use.Adverse health effects due to smoke exposure also impacted people without respiratory conditions.However, people with respiratory conditions are at greater risk and should be a priority for mitigation measures into the future.
ATRIAL FIBRILLATION ABLATION IS ASSOCIATED WITH CHANGES IN LEFT ATRIAL APPENDAGE AND LEFT ATRIAL ANATOMY
Authors: Lilas Dagher, Yichi Zhang, Aneesh Dhore, Michael Crawford, Tarek Ayoub, Alan Morris, Eugene Kholmovski, Raman Danrad, Chao Huang, Nassir Marrouche
Journal: Journal of the American College of Cardiology (2021)
Surveillance data for human leishmaniasis indicate the need for a sustainable action plan for its management and control, Greece, 2004 to 2018
Authors: Myrsini Tzani, Alicia Barrasa, Annita Vakali, Theano Georgakopoulou, Kassiani Mellou, Danai Pervanidou
Journal: Eurosurveillance (2021)

BackgroundThe World Health Organization (WHO) lists human leishmaniasis as a neglected tropical disease; it is not under surveillance at European level.AimWe present surveillance data for visceral (VL) and cutaneous (CL) leishmaniasis for the period 2004 to 2018 in Greece to assess their public health importance.MethodsWe extracted data from the mandatory notification system to analyse separately imported and domestic cases of VL and CL. A case was defined by clinical manifestations compatible with VL or CL and laboratory confirmation.ResultsBetween 2004 and 2018, 881 VL (862 domestic, 19 imported) and 58 CL cases (24 domestic, 34 imported) were recorded. The mean annual notification rate of domestic VL was 0.5 per 100,000 (range: 0.12-1.43/100,000) with a statistically significant increasing trend (p = 0.013). Cases were reported by all regions. The highest notification rate occurred in the age group 0-4 years (1.3/100,000). Overall 24% (164/680) of the cases were immunocompromised and their proportion increased after 2010 (p < 0.001). The mean annual notification rate of domestic CL was 0.05 per 100,000 (range: 0.01-0.19/100,000) with the highest rate in the age group 5-14 years (0.03/100,000). Cases were recorded in six of the 13 regions. Among 34 imported CL cases, 29 were foreign nationals.ConclusionVL is endemic in Greece, with an increasing trend and a considerable burden of severe disease and young children being most affected. CL is rarely reported. A sustainable action plan is needed to reduce the burden of VL and prevent local transmission of CL.
SARS-CoV-2 elimination, not mitigation, creates best outcomes for health, the economy, and civil liberties
Authors: Miquel Oliu-Barton, Bary S R Pradelski, Philippe Aghion, Patrick Artus, Ilona Kickbusch, Jeffrey V Lazarus, Devi Sridhar, Samantha Vanderslott
Journal: The Lancet (2021)
<i>MGMT</i>promoter methylation testing to predict overall survival in people with glioblastoma treated with temozolomide: a comprehensive meta-analysis based on a Cochrane Systematic Review
Authors: Sebastian Brandner, Alexandra McAleenan, Claire Kelly, Francesca Spiga, Hung-Yuan Cheng, Sarah Dawson, Lena Schmidt, Claire L Faulkner, Christopher Wragg, Sarah Jefferies, Julian P T Higgins, Kathreena M Kurian
Journal: Neuro-Oncology (2021)

The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) causes resistance of tumor cells to alkylating agents. It is a predictive biomarker in high-grade gliomas treated with temozolomide, however, there is no consensus on which test method, methylation sites, and cutoff values to use.
ELEVATED RESTING HEART RATE IS A MARKER OF SUBCLINICAL LEFT VENTRICULAR DYSFUNCTION IN HODGKIN LYMPHOMA SURVIVORS
Authors: Julius C. Heemelaar, Augstinus D.G. Krol, Marloes Louwerens, Saskia L. M.A. Beeres, Eduard R. Holman, Martin J. Schalij, Maria Louisa Antoni
Journal: Journal of the American College of Cardiology (2021)
Ethical Issues in Human Genome Epidemiology: A Case Study Based on the Japanese American Family Study
Authors: Melissa A Austin
Journal: Circulation (2001)

P21 The rapid advances in genetics and molecular biology are dramatically increasing our ability to understand genetic susceptibility to disease and to develop targeted prevention strategies using genetic and molecular epidemiology approaches. The implementation of these human genome epidemiology studies, however, raises serious ethical concerns. This analysis used a “case study” approach to explore ethical issues in the context on the ongoing Japanese American Family Study in Seattle, a population-based study of extended kindreds of Japanese descent living in a Western Culture that is examining genetic influences on risk factors for cardiovascular disease and diabetes. Issues related to study design, protocol implementation, and reporting study results were considered. Study design issues include the advanatages and disadvantages of using a genetically homogeneous group for study. Selecting such a population may decrease genetic heterogeneity and increase the possibilty of detecting genetics effects. However the potential social effects of such findings, including stigmatizing the group under study, must be considered. Further, whether or not it is appropriate to obtain community consent remains a controversial issue. In implementing a community-based family study, maintaining the confidentially of study data is essential, especially for individuals within families. Avoiding coercion of family members can be difficult in certain cultural settings, and informed consent for DNA banking requires specific informed consent procedures. Once the study results are available, investigators must make difficult decisions about whether or not to provide genotyping results to study participants, and when to involve genetic counselors. Finally, publishing the study results that include pedigrees, while avoiding identifying family information, is challenging. Careful analysis of ethical issues in study design, protocol implementation, and reporting study results can provide useful guidance for the successful completion of human genome epidemiology studies.
Abstract 15140: Age Associated Hypertension Leads to Blood Pressure-Dependent Changes in the Brain of Hypertensive Dahl-Salt Sensitive Rats, in the Absence of High Salt Intake
Authors: Rebecca L McPherson, Ken W Fishbein, Wen Wei, Yulia N Grigorova, Valentina Zernetkina, Richard G Spencer, Edward G Lakatta, Olga V Fedorova
Journal: Circulation (2017)

Arterial wall remodeling occurs during aging and in response to age-associated stress, injury and disease, such as hypertension. These processes lead to a decline in cerebral blood flow, brain volu...