tbuckley/cabot-search huggingface dataset:
Covid-19: Female NHS and care staff report deteriorating health because of pandemic
Authors: Gareth Iacobucci
Journal: BMJ (2021)

Covid-19: Female NHS and care staff report deteriorating health because of pandemic Gareth IacobucciFemale health and care staff in England have experienced significantly worsening physical and mental health since last year as a result of working through the covid-19 pandemic, a survey 1 has found. 1 NHS Confederation.Covid-19 and the female health and care workforce survey update.May 2021.www.nhsconfed.
No country or continent is on its own in the ongoing COVID-19 pandemic
Authors: Kari Johansen, Hanna Nohynek
Journal: Eurosurveillance (2021)

Preview this article: No country or continent is on its own in the ongoing COVID-19 pandemic, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/26/17/eurosurv-26-17-1-1.gif
MARS: leveraging allelic heterogeneity to increase power of association testing
Authors: Farhad Hormozdiari, Junghyun Jung, Eleazar Eskin, Jong Wha J. Joo
Journal: Genome biology (2021)

Abstract In standard genome-wide association studies (GWAS), the standard association test is underpowered to detect associations between loci with multiple causal variants with small effect sizes. We propose a statistical method, Model-based Association test Reflecting causal Status (MARS), that finds associations between variants in risk loci and a phenotype, considering the causal status of variants, only requiring the existing summary statistics to detect associated risk loci. Utilizing extensive simulated data and real data, we show that MARS increases the power of detecting true associated risk loci compared to previous approaches that consider multiple variants, while controlling the type I error.
STATINS AND SEVERITY OF CLINICAL MANIFESTATIONS AMONG WOMEN AND MEN WITH INCIDENT CORONARY HEART DISEASE
Authors: Edina Cenko, Maria Bergami, Jinsung Yoon, Natalia Fabin, Mihaela van der Schaar, Olivia Manfrini, Zorana Vasiljevic, Marija Zdravkovic, Marija Vavlukis, Sasko Kedev, Davor Milicic, Lina Badimon, Raffaele Bugiardini
Journal: Journal of the American College of Cardiology (2021)
RELATIONSHIP BETWEEN LEFT ATRIAL MYOPATHY AND ATRIAL FIBRILLATION IN ADULTS WITH COARCTATION OF AORTA
Authors: Alexander C. Egbe, Renuka Reddy Katta, Likhita Shaik, Janaki Devara, Momina Iftikhar, Heidi Connolly
Journal: Journal of the American College of Cardiology (2021)
A latent subset of human hematopoietic stem cells resists regenerative stress to preserve stemness
Authors: Kerstin B. Kaufmann, Andy G. X. Zeng, Etienne Coyaud, Laura Garcia-Prat, Efthymia Papalexi, Alex Murison, Estelle M. N. Laurent, Michelle Chan-Seng-Yue, Olga I. Gan, Kristele Pan, Jessica McLeod, Héléna Boutzen, Sasan Zandi, Shin-ichiro Takayanagi, Rahul Satija, Brian Raught, Stephanie Z. Xie, John E. Dick
Journal: Nature Immunology (2021)
Association of Hair Loss With Suicidality and Psychological Adverse Events vs Finasteride Use—Reply
Authors: David-Dan Nguyen, Eugene B. Cone, Quoc-Dien Trinh
Journal: JAMA Dermatology (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Spatial Transcriptomics: Molecular Maps of the Mammalian Brain
Authors: Cantin Ortiz, Marie Carlén, Konstantinos Meletis
Journal: Annual Review of Neuroscience (2021)

Maps of the nervous system inspire experiments and theories in neuroscience. Advances in molecular biology over the past decades have revolutionized the definition of cell and tissue identity. Spatial transcriptomics has opened up a new era in neuroanatomy, where the unsupervised and unbiased exploration of the molecular signatures of tissue organization will give rise to a new generation of brain maps. We propose that the molecular classification of brain regions on the basis of their gene expression profile can circumvent subjective neuroanatomical definitions and produce common reference frameworks that can incorporate cell types, connectivity, activity, and other modalities. Here we review the technological and conceptual advances made possible by spatial transcriptomics in the context of advancing neuroanatomy and discuss how molecular neuroanatomy can redefine mapping of the nervous system.
TRANSITIONS OF CARE FOR PATIENTS DISCHARGED FROM THE EMERGENCY ROOM WITH NON-OBSTRUCTIVE DISEASE ON CORONARY CT-ANGIOGRAPHY
Authors: Caleb Wutawunashe, Zain Kassam, Eric Czinn, Nirav Shah, Gregg A. Husk, Brandon J. Godbout, Eric Cruzen, Eugenia Gianos
Journal: Journal of the American College of Cardiology (2021)
Machine learning-assisted immune profiling stratifies peri-implantitis patients with unique microbial colonization and clinical outcomes
Authors: Chin-Wei Wang, Yuning Hao, Riccardo Di Gianfilippo, James Sugai, Jiaqian Li, Wang Gong, Kenneth S. Kornman, Hom-Lay Wang, Nobuhiko Kamada, Yuying Xie, William V. Giannobile, Yu Leo Lei
Journal: Theranostics (2021)

Rationale: The endemic of peri-implantitis affects over 25% of dental implants. Current treatment depends on empirical patient and site-based stratifications and lacks a consistent risk grading system. Methods: We investigated a unique cohort of peri-implantitis patients undergoing regenerative therapy with comprehensive clinical, immune, and microbial profiling. We utilized a robust outlier-resistant machine learning algorithm for immune deconvolution. Results: Unsupervised clustering identified risk groups with distinct immune profiles, microbial colonization dynamics, and regenerative outcomes. Low-risk patients exhibited elevated M1/M2-like macrophage ratios and lower B-cell infiltration. The low-risk immune profile was characterized by enhanced complement signaling and higher levels of Th1 and Th17 cytokines. Fusobacterium nucleatum and Prevotella intermedia were significantly enriched in high-risk individuals. Although surgery reduced microbial burden at the peri-implant interface in all groups, only low-risk individuals exhibited suppression of keystone pathogen re-colonization. Conclusion: Peri-implant immune microenvironment shapes microbial composition and the course of regeneration. Immune signatures show untapped potential in improving the risk-grading for peri-implantitis.
Minimal Residual Disease Detection using a Plasma-only Circulating Tumor DNA Assay in Patients with Colorectal Cancer
Authors: Aparna R. Parikh, Emily E. Van Seventer, Giulia Siravegna, Anna V. Hartwig, Ariel Jaimovich, Yupeng He, Katie Kanter, Madeleine G. Fish, Kathryn D. Fosbenner, Benchun Miao, Susannah Phillips, John H. Carmichael, Nihaarika Sharma, Joy Jarnagin, Islam Baiev, Yojan S. Shah, Isobel J. Fetter, Heather A. Shahzade, Jill N. Allen, Lawrence S. Blaszkowsky, Jeffrey W. Clark, Jon S. Dubois, Joseph W. Franses, Bruce J. Giantonio, Lipika Goyal, Samuel J. Klempner, Ryan D. Nipp, Eric J. Roeland, David P. Ryan, Colin D. Weekes, Jennifer Y. Wo, Theodore S. Hong, Liliana Bordeianou, Cristina R. Ferrone, Motaz Qadan, Hiroko Kunitake, David Berger, Rocco Ricciardi, James C. Cusack, Victoria M. Raymond, AmirAli Talasaz, Genevieve M. Boland, Ryan B. Corcoran
Journal: Clinical Cancer Research (2021)

Abstract Purpose: Detection of persistent circulating tumor DNA (ctDNA) after curative-intent surgery can identify patients with minimal residual disease (MRD) who will ultimately recur. Most ctDNA MRD assays require tumor sequencing to identify tumor-derived mutations to facilitate ctDNA detection, requiring tumor and blood. We evaluated a plasma-only ctDNA assay integrating genomic and epigenomic cancer signatures to enable tumor-uninformed MRD detection. Experimental Design: A total of 252 prospective serial plasma specimens from 103 patients with colorectal cancer undergoing curative-intent surgery were analyzed and correlated with recurrence. Results: Of 103 patients, 84 [stage I (9.5%), II (23.8%), III (47.6%), IV (19%)] had evaluable plasma drawn after completion of definitive therapy, defined as surgery only (n = 39) or completion of adjuvant therapy (n = 45). In “landmark” plasma drawn 1-month (median, 31.5 days) after definitive therapy and &amp;gt;1 year follow-up, 15 patients had detectable ctDNA, and all 15 recurred [positive predictive value (PPV), 100%; HR, 11.28 (P &amp;lt; 0.0001)]. Of 49 patients without detectable ctDNA at the landmark timepoint, 12 (24.5%) recurred. Landmark recurrence sensitivity and specificity were 55.6% and 100%. Incorporating serial longitudinal and surveillance (drawn within 4 months of recurrence) samples, sensitivity improved to 69% and 91%. Integrating epigenomic signatures increased sensitivity by 25%–36% versus genomic alterations alone. Notably, standard serum carcinoembryonic antigen levels did not predict recurrence [HR, 1.84 (P = 0.18); PPV = 53.9%]. Conclusions: Plasma-only MRD detection demonstrated favorable sensitivity and specificity for recurrence, comparable with tumor-informed approaches. Integrating analysis of epigenomic and genomic alterations enhanced sensitivity. These findings support the potential clinical utility of plasma-only ctDNA MRD detection. See related commentary by Bent and Kopetz, p. 5449
Esophageal stenting for benign and malignant disease: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Update 2021
Authors: Manon C. W. Spaander, Ruben D. van der Bogt, Todd H. Baron, David Albers, Daniel Blero, Antonella de Ceglie, Massimo Conio, László Czakó, Simon Everett, Juan-Carlos Garcia-Pagán, Angels Ginès, Manol Jovani, Alessandro Repici, Eduardo Rodrigues-Pinto, Peter D. Siersema, Lorenzo Fuccio, Jeanin E. van Hooft
Journal: Endoscopy (2021)

Main recommendations Malignant disease 1 ESGE recommends placement of partially or fully covered self-expandable metal stents (SEMSs) for palliation of malignant dysphagia over laser therapy, photodynamic therapy, and esophageal bypass. Strong recommendation, high quality evidence. 2 ESGE recommends brachytherapy as a valid alternative, alone or in addition to stenting, in esophageal cancer patients with malignant dysphagia and expected longer life expectancy. Strong recommendation, high quality evidence. 3 ESGE recommends esophageal SEMS placement for sealing malignant tracheoesophageal or bronchoesophageal fistulas. Strong recommendation, low quality evidence. 4 ESGE does not recommend SEMS placement as a bridge to surgery or before preoperative chemoradiotherapy because it is associated with a high incidence of adverse events. Other options such as feeding tube placement are preferable. Strong recommendation, low quality evidence. Benign disease 5 ESGE recommends against the use of SEMSs as first-line therapy for the management of benign esophageal strictures because of the potential for adverse events, the availability of alternative therapies, and their cost. Strong recommendation, low quality evidence. 6 ESGE suggests consideration of temporary placement of self-expandable stents for refractory benign esophageal strictures. Weak recommendation, moderate quality evidence. 7 ESGE suggests that fully covered SEMSs be preferred over partially covered SEMSs for the treatment of refractory benign esophageal strictures because of their very low risk of embedment and ease of removability. Weak recommendation, low quality evidence. 8 ESGE recommends the stent-in-stent technique to remove partially covered SEMSs that are embedded in the esophageal wall. Strong recommendation, low quality evidence. 9 ESGE recommends that temporary stent placement can be considered for the treatment of leaks, fistulas, and perforations. No specific type of stent can be recommended, and the duration of stenting should be individualized. Strong recommendation, low quality of evidence. 10 ESGE recommends considering placement of a fully covered large-diameter SEMS for the treatment of esophageal variceal bleeding refractory to medical, endoscopic, and/or radiological therapy, or as initial therapy for patients with massive bleeding. Strong recommendation, moderate quality evidence.
Serial 18F-FP-CIT and FDG PET in Fulminant Corticobasal Syndrome
Authors: Don Gueu Park, Young Sil An, Jung Han Yoon
Journal: Clinical Nuclear Medicine (2021)

Abstract Corticobasal syndrome (CBS) is characterized by a slow progressive cognitive decline, apraxia, myoclonus, dystonia, and parkinsonism. We experienced a rapidly progressing CBS patient (onset to bed-ridden within 2 years) presenting only with resting tremor but showing complete unilateral loss of dopamine transporter binding. This case exhibited distinct FDG PET findings involving the unilateral severe anterior frontal cortex, caudate nucleus, and contralateral cerebellum, which is different from classical CBS. However, to date, no detailed serial functional imaging study has been performed in rapidly progressing CBS, so these FDG PET and CIT PET findings may help clinicians to recognize this fulminant type of corticobasal degeneration.
NO EXCESS MORTALITY ASSOCIATED WITH CONCOMITANT ACE INHIBITOR OR ARB USE IN HOSPITALIZED PATIENTS WITH COVID-19
Authors: Frank H. Annie, Mark Bates, Sarah Embrey, Mohamad Alkhouli, Deepak Bhatt, Jacob Misenheimer, Hannah George, Ronald Gwinn, Aravinda Nanjundappa
Journal: Journal of the American College of Cardiology (2021)
Comprehensive Molecular and Clinicopathologic Analysis of 200 Pulmonary Invasive Mucinous Adenocarcinomas Identifies Distinct Characteristics of Molecular Subtypes
Authors: Jason C. Chang, Michael Offin, Christina Falcon, David Brown, Brian R. Houck-Loomis, Fanli Meng, Vasilisa A. Rudneva, Helen H. Won, Sharon Amir, Joseph Montecalvo, Patrice Desmeules, Kyuichi Kadota, Prasad S. Adusumilli, Valerie W. Rusch, Sarah Teed, Joshua K. Sabari, Ryma Benayed, Khedoudja Nafa, Laetitia Borsu, Bob T. Li, Alison M. Schram, Maria E. Arcila, William D. Travis, Marc Ladanyi, Alexander Drilon, Natasha Rekhtman
Journal: Clinical Cancer Research (2021)

Abstract Purpose: Invasive mucinous adenocarcinoma (IMA) is a unique subtype of lung adenocarcinoma, characterized genomically by frequent KRAS mutations or specific gene fusions, most commonly involving NRG1. Comprehensive analysis of a large series of IMAs using broad DNA- and RNA-sequencing methods is still lacking, and it remains unclear whether molecular subtypes of IMA differ clinicopathologically. Experimental Design: A total of 200 IMAs were analyzed by 410-gene DNA next-generation sequencing (MSK-IMPACT; n = 136) or hotspot 8-oncogene genotyping (n = 64). Driver-negative cases were further analyzed by 62-gene RNA sequencing (MSK-Fusion) and those lacking fusions were further tested by whole-exome sequencing and whole-transcriptome sequencing (WTS). Results: Combined MSK-IMPACT and MSK-Fusion testing identified mutually exclusive driver alterations in 96% of IMAs, including KRAS mutations (76%), NRG1 fusions (7%), ERBB2 alterations (6%), and other less common events. In addition, WTS identified a novel NRG2 fusion (F11R–NRG2). Overall, targetable gene fusions were identified in 51% of KRAS wild-type IMAs, leading to durable responses to targeted therapy in some patients. Compared with KRAS-mutant IMAs, NRG1-rearranged tumors exhibited several more aggressive characteristics, including worse recurrence-free survival (P &amp;lt; 0.0001). Conclusions: This is the largest molecular study of IMAs to date, where we demonstrate the presence of a major oncogenic driver in nearly all cases. This study is the first to document more aggressive characteristics of NRG1-rearranged IMAs, ERBB2 as the third most common alteration, and a novel NRG2 fusion in these tumors. Comprehensive molecular testing of KRAS wild-type IMAs that includes fusion testing is essential, given the high prevalence of alterations with established and investigational targeted therapies in this subset.
OUTCOMES FOLLOWING TELEHEALTH VISITS DURING THE COVID-19 PANDEMIC IN AN ADVANCED HEART FAILURE PRACTICE
Authors: Gabriel Sayer, Sharon Slomovich, MaryJane Farr, Jayant Raikhelkar, Kevin Clerkin, Jan Griffin, Veli Topkara, Kelly Axsom, Justin Fried, Melana Yuzefpolskaya, Paolo Colombo, Mathew Maurer, Nir Uriel
Journal: Journal of the American College of Cardiology (2021)
Variations in the characteristics and outcomes of children living with HIV following universal ART in sub-Saharan Africa (2006–17): a retrospective cohort study
Authors: Victoria Iyun, Karl-Gunter Technau, Michael Vinikoor, Marcel Yotebieng, Rachel Vreeman, Lisa Abuogi, Sophie Desmonde, Andrew Edmonds, Madeleine Amorissani-Folquet, Mary-Ann Davies
Journal: The Lancet HIV (2021)
ADDED PREDICTIVE VALUE OF VENOUS LACTATE LEVEL AT ADMISSION IN STEMI PATIENTS TREATED WITH PRIMARY PCI - PRELIMINARY RESULTS OF A REAL-WORLD REGISTRY
Authors: Dominika Szabó, András Szabó, Szilvia Kugler, Anita Pintér, Vencel Juhász, Mihály Ruppert, Attila Oláh, István Édes, Dávid Becker, Béla Merkely, Istvan Hizoh
Journal: Journal of the American College of Cardiology (2021)
Natural Killer Cells: From Innate to Adaptive Features
Authors: Adriana M. Mujal, Rebecca B. Delconte, Joseph C. Sun
Journal: Annual Review of Immunology (2021)

Natural killer (NK) cells are innate lymphocytes that provide critical host defense against pathogens and cancer. Originally heralded for their early and rapid effector activity, NK cells have been recognized over the last decade for their ability to undergo adaptive immune processes, including antigen-driven clonal expansion and generation of long-lived memory. This review presents an overview of how NK cells lithely partake in both innate and adaptive responses and how this versatility is manifest in human NK cell–mediated immunity.
CLINICAL PRESENTATION, DEMOGRAPHICS AND IN-HOSPITAL OUTCOME IN PATIENTS ADMITTED WITH MODERATE TO SEVERE COVID-19: MIDDLE EASTERN MULTICENTER DATA
Authors: Fahad Alkindi, Tasneem Alrashdi, Salma Alharthi, Muzna Alfarsi, Maather AlAbri, Maryam Alissai, Shihab Alkindi, Shabib Alasmi, Khalid Alsaidi, Adil Alghafri, Sultan Allawati, Khamis Alhashmi, Sathiya Murthui, Sunil K Nadar, Hilal Alsabti
Journal: Journal of the American College of Cardiology (2021)
UNDERSTANDING SPECTRUM BIAS IN ALGORITHMS DERIVED BY ARTIFICIAL INTELLIGENCE A CASE STUDY IN DETECTING AORTIC STENOSIS USING ELECTROCARDIOGRAMS
Authors: Andrew S. Tseng, Michal Shelly-Cohen, Zachi Itzhak Attia, Peter Noseworthy, Paul Friedman, Francisco Lopez-Jimenez
Journal: Journal of the American College of Cardiology (2021)
Typical gastric mucosa with ulcer found by endoscopy in Meckel’s diverticulum
Authors: Hong Zhang, Zhen Yang, Yan-Hong Wang, Shi-Ming Yang, Lu Liu, Jian-Ying Bai, Chao-Qiang Fan
Journal: Endoscopy (2021)

A 19-year-old male experienced recurrent rectal bleeding and syncope twice within a month. Laboratory examination showed iron-deficiency anemia with a low hemoglobin level of 78 g/L. Gastrointestinal endoscopy revealed only a tiny ulcer in the gastric antrum (0.3 cm in diameter, healing period), and no abnormality was observed in the large intestine. Transanal single-balloon enteroscopy revealed a bifurcation of the intestinal tract 100 cm from the ileocecal valve, and a diagnosis of Meckel’s diverticulum with ulcer (0.5 cm in diameter, active period) was considered ([Fig. 1]). The boundary between the small intestinal villi and gastric mucosa was clearly observed on narrow-band imaging and after indigo carmine staining ([Fig. 2], [Fig. 3]; [Video 1]). We diagnosed the patient with ectopic gastric mucosa with ulcer in Meckel’s diverticulum on the basis of the endoscopic manifestation; in previous reports this diagnosis relied on pathological analysis rather than endoscopic observation. The patient subsequently underwent surgery, and pathological analysis (including MUC5AC antibody reaction) confirmed the presence of ectopic gastric mucosa with ulcer ([Fig. 4], [Fig. 5]). The patient has since been asymptomatic on follow-up.
LARGE SINGLE CENTER EXPERIENCE WITH MANTA VASCULAR CLOSURE DEVICE IN TRANSCATHETER AORTIC VALVE REPLACEMENT AND MECHANICAL CIRCULATORY SUPPORT
Authors: Besher Sadat, Mariam Saleem, Alejandro Lemor, Mohammed Qintar, Tiberio Frisoli, Marvin Eng, Brian O’Neill, Dee Dee Wang, Khaldoon Alaswad, Mir Basir, James Lee, William O’Neill, Pedro Villablanca
Journal: Journal of the American College of Cardiology (2021)
Development of a multiplex RT-qPCR using the drop out strategy to screen the SARS-CoV-2 South African 501Y.V2 variant
Authors: François Maclot, Sébastien Bontems, Cécile Meex, Maria Artesi, Pablo Beckers, Vincent Bours, Keith Durkin, Marie-Pierre Hayette
Journal: Journal of Infection (2021)
Neoadjuvant immunoradiotherapy results in high rate of complete pathological response and clinical to pathological downstaging in locally advanced head and neck squamous cell carcinoma
Authors: Rom Leidner, Marka Crittenden, Kristina Young, Hong Xiao, Yaping Wu, Marcus A Couey, Ashish A Patel, Allen C Cheng, Amber L Watters, Carlo Bifulco, George Morris, Lessli Rushforth, Shorin Nemeth, Walter J Urba, Michael Gough, R Bryan Bell
Journal: Journal for ImmunoTherapy of Cancer (2021)

Background Checkpoint inhibitors targeting programmed death receptor-1 (PD-1) have been tested in the neoadjuvant setting for the treatment of locoregionally advanced head and neck squamous cell carcinoma (HNSCC); however, response rates are modest. We hypothesized that adding stereotactic body radiation therapy (SBRT) to anti-PD-1 would be safe prior to definitive surgical resection and would enhance pathological response compared with historical cohorts of patients with locoregionally advanced HNSCC treated with checkpoint inhibitor alone. Methods The Neoadjuvant Immuno-Radiotherapy Trial was an investigator-initiated single institution phase Ib clinical trial that enrolled patients with previously untreated locally advanced HPV-positive and HPV-negative HNSCC between 2018 and 2019. Eligible patients were treated with neoadjuvant SBRT at a total dose of either 40 Gy in 5 fractions or 24 Gy in 3 fractions, delivered in a 1-week timespan, with or without nivolumab, prior to definitive surgical resection. Patients were then planned for treatment with adjuvant nivolumab for 3 months. The primary safety endpoint was unplanned delay in surgery considered to be at least possibly related to neoadjuvant treatment. The primary efficacy endpoints included pathological complete response (pCR), major pathological response (mPR), and the rate of clinical to pathological downstaging after neoadjuvant treatment. Results Twenty-one patients underwent neoadjuvant treatment, which was well tolerated and did not delay surgery, thus meeting the primary endpoint. Tissue responses were characterized by robust inflammatory infiltrates in the regression bed, plasma cells and cholesterol clefts. Among the entire study group, the mPR and pCR rate was 86% and 67%, respectively. Clinical to pathological downstaging occurred in 90% of the patients treated. Conclusion These data demonstrate that radiation delivered only to the gross tumor volume combined with immunotherapy was safe, resulted in a high rate of mPR and should be further evaluated as a locally focused neoadjuvant therapy for patients with head and neck cancer. Trial registration number This study is registered with clinicaltrials.gov ( NCT03247712 ) and is active, but closed to patient accrual.