tbuckley/cabot-search huggingface dataset:
Abstract 3749: Metabolic reprogramming by <i>GCN1</i> mediates metastatic reactivation and outgrowth at liver metastatic site in response to glutamine deprivation in pancreatic cancer
Authors: Surajit Sinha, Jonathan Hernandez, Reed Ayabe, Michael Wach, Samantha Ruff, Alok Ranjan, Kirsten Remmert, Imani Alexander
Journal: Cancer Research (2019)

Abstract Introduction: Disseminated tumor cells in the circulation upon extravasation into a secondary organ like the liver encounter hostile conditions like nutrient deprivation and oxidative stress and may undergo dormancy or growth arrest. The molecular drivers and mechanisms that enable disseminated tumor cells to overcome such adverse growth conditions and revert to proliferative stage are unknown. Method: To identify these molecular drivers, a retroviral cDNA library was generated from a highly metastatic pancreatic cell line (M-4964Liv) derived from a KPC mouse which forms macroscopic liver lesions upon splenic injection in mice. The cDNA library was then transduced into a dormant pancreatic KPC cells (D-4964Liv) cells which does not give liver lesions upon splenic injection in mice. This methodology will allow all the cDNA’s from the metastatic cells to express in the dormant cells but only those cDNA’s which can trigger the dormant cells to outgrow will give rise to a metastatic liver lesion. Results: The screening strategy led to the identification of general control of amino-acid synthesis 1-like 1 (GCN1L1). The human homologue GCN1 has been shown to regulate the activation of mammalian amino acid sensor general control non-derepressible 2 (GCN2) under amino acid starvation in budding yeast but how GCN1 regulates metastatic reactivation is not known. We show that GCN1 is activated under physiologic glutamine levels in the liver which is around 0.5 mM compared to standard tissue culture levels of 2-4 mM. Mechanistic interrogation revealed that GCN1 activates both the mammalian amino acid sensors: the general control nonderepressible 2 (GCN2) and the mechanistic target of rapamycin complex 1 (mTORC1) leading to metastatic outgrowth in vivo. Contrary, knockdown of GCN1 dramatically impairs the activation of GCN2 and mTORC1 and abrogates liver metastatic outgrowth upon splenic injection in immunocompetent mice. Conclusions: These results suggest that under physiologic glutamine levels, induction of GCN1 activates two different pathways: One pathway impinges on ATF4 and the other on mTORC1. While ATF4 activation promotes metabolic homeostasis by inducing de novo amino acid synthesis, the activation of mTOR pathway ensures re-entry in to the cell cycle leading to metastatic reactivation and outgrowth. Citation Format: Surajit Sinha, Jonathan Hernandez, Reed Ayabe, Michael Wach, Samantha Ruff, Alok Ranjan, Kirsten Remmert, Imani Alexander. Metabolic reprogramming by GCN1 mediates metastatic reactivation and outgrowth at liver metastatic site in response to glutamine deprivation in pancreatic cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3749.
A Handbook of the Diseases of the Eye and their Treatment.
Authors: None C. E. W.
Journal: JAMA (1885)

This book is designed by the author as a handbook for the use of students of ophthalmology. It is condensed in style and broad in scope, covering all departments of the subject. Its chief use to the practitioner will be as a book of ready reference when memory fails him in some matter of diagnosis or treatment. The chapter on the eyelids treats of the various plastic operations for the relief of the distortions of these organs. In chapter xiv the motions of the pupil in health and disease are considered. Myosis may be caused by a diseased process irritating the pupil-contracting centre or fibres, or by one causing paralysis of the pupil-dilating centre or fibres, or by a combination of both. The reverse of this irritation or paralysis, or both, would give rise to mydriasis. The following is a brief abstract from the portion of this chapter which refers
The Gemini Flight
Journal: JAMA (1965)

Weightlessness is still the major concern of physicians directing space operations. However, with each longer and more ambitious flight, new medical challenges arise. The medical director of the next United States manned space flight is responsible for many things in his varied job including (1) the astronauts—their conditions and responses in relation to flight; (2) medical experiments aimed at some of the unanswered problems of space flight, and (3) research and development of equipment, food, basic health requirements, and the like. That medical director is Charles A. Berry, MD. He is chief of center medical programs, National Aeronautics and Space Administration-Manned Spacecraft Center, Houston, and is director of medical operations for each manned space mission. A graduate of the University of California where he received his Doctor of Medicine degree in 1947, Berry was engaged in general practice before entering the Air Force's Aviation Medicine residency training program. He left
Journal National Cancer Institute, Washington
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
This Week in JAMA
Journal: JAMA (2011)

A Piece of My Mind"The central determinants of health care costs are physician habits, attitudes, and behaviors.In every clinical encounter, multiple decisions are made with significant financial consequences."From "Fix It!" SEE PAGE 2544 Medical News & PerspectivesThe recent recommendation by the US Preventive Services Task Force advising against prostate-specific antigen-based screening for prostate cancer has provoked considerable debate in the medical community.
Chemistry of Mutagens and Carcinogens in Broiled Food
Authors: Susumu Nishimura
Journal: Environmental Health Perspectives (1986)

From a chemical point of view, the following subjects are important areas in studies on mutagens and carcinogens in broiled foods. In addition to heterocyclic amines which need microsomal activation, the structural elucidation of more labile direct-acting mutagens is necessary. It is known that there are still various unknown minor mutagens in broiled foods. Although the structural characterization of such compounds is more difficult, it is important since they might be hazardous in spite of their low mutagenicity. A more feasible and easier method for quantitative analysis of mutagens, in addition to HPLC and GC/MS methods presently employed, must be developed. The mechanism of formation of mutagens by broiling of food should be studied. An effective chemical method to prevent formation of mutagens or to destroy them, once formed, should be developed.
Headache History
Authors: Robert Ferrari
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Hormones: Physiology, Chemistry and Applications. Volume I
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Some sobering facts about laughing gas
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum
Journal: Endocrine Reviews (1983)

Journal Article Travel Grants—Seventh International Congress of Endocrinology—July 1–7, 1984 Get access Endocrine Reviews, Volume 4, Issue 4, 1 October 1983, Page 377, https://doi.org/10.1210/edrv-4-4-377a Published: 01 October 1983
Contraceptives and acute salpingitis
Authors: L. Svensson
Journal: JAMA (1984)

In 546 women with a first episode of salpingitis, the degree of inflammation of the fallopian tubes, as seen during laparoscopy, was graded into mild, moderate, and severe. The patients were subgrouped according to contraceptive use into (1) reference group (women not using intrauterine [contraceptive] devices [IUDs] or oral contraceptives [OCs]), (2) IUD group, and (3) OC group. Mild, moderate, and severe salpingitis occurred in 51.3%, 34.6%, and 24.1% of the women in the reference group. The corresponding percentages for the women in the IUD group were 54.6%, 29.7%, and 15.7% and for the patients in the OC group, 73.5%, 17.1%, and 9.4%, respectively. Women using OCs had significantly milder degrees of inflammation of the fallopian tubes than women with other contraceptive methods. Age could not explain the differences. (<i>JAMA</i>1984;251:2553-2555)
Correction
Journal: BMJ (1961)

ANY QUESTIONS ?then he is an example of uncomplicated hypertension, presumably essential in nature.There is no reason to suppose that the blood-pressure readings are at variance with the clinical condition in any way.It is common for mild or moderately severe hypertension to be unassociated with symptoms or with complications, and there is no obvious reason why the blood-pressure reading should not be correct.In view of the lack of complications, the prognosis is good, provided that occult coronary or cerebral-artery disease does not coexist with the hypertension.From the story, however, there is no particular reason to suspect this.
Coronary Arteriography
Authors: Hratch Kasparian
Journal: JAMA (1966)

Coronary arteriography is a radiographic exploration of the coronary vessels in living subjects. This procedure was initiated about 32 years ago when Peter Rousthöi demonstrated angiographically the coronary arteries in intact experimental animals.<sup>1</sup>Radner, in 1945, was able to perform the technique in the living man.<sup>2</sup>Although the initial attempts at vascular opacification were viewed with considerable ridicule by skeptical onlookers, enough experience has been accumulated to consider the procedure safe and reasonably accurate. This accomplishment was made possible through the development of new contrast media and significant improvement of roentgenographic and catheterization techniques. Presently, two basically different approaches are used for contrast visualization of the coronary arteries: catheter thoracic aortography and selective catheter coronary arteriography.<sup>3</sup>In thoracic aortography, improved filling of the coronary arteries is accomplished when attempts are made to decrease the cardiac output, prolong the ventricular diastole, or obstruct the thoracic aorta. Catheterization of
Additive inhibitory effect of hydrocortisone and cyclosporine on low-density lipoprotein receptor activity in cultured HepG2 cells
Authors: O Al Rayyes
Journal: Hepatology (1997)

Both glucocorticoids and cyclosporine are used to prevent rejection in organ transplant recipients. However, long-term treatment with these drugs is known to induce hyperlipidemia and premature development of atherosclerosis. In previous studies, we have shown that the immunosuppressive drug cyclosporine inhibits catabolism of low-density lipoproteins (LDL) mainly by reducing the expression of LDL-receptor messenger RNA (mRNA), thus explaining the increased plasma levels of LDL cholesterol observed in patients treated with cyclosporine. In the present study, our objective was to investigate the mechanism by which glucocorticoids increase plasma levels of LDL cholesterol. We studied the catabolism of LDL in the human hepatoma cell line HepG2. Our results show that hydrocortisone at physiologically relevant concentrations inhibits LDL binding, uptake, and degradation in a dose-dependent way. Moreover, hydrocortisone also reduces the expression of LDL-receptor mRNA in a dose-dependent way. Cyclosporine also has an additive inhibitory effect on hydrocortisone in the catabolism of LDL. The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor fluvastatin reverses the inhibitory effect of both hydrocortisone and cyclosporine. We conclude that treatment with hydrocortisone and/or cyclosporine induces increased plasma levels of LDL cholesterol because of reduced hepatic LDL receptor activity. HMG-CoA reductase inhibitors reverse this undesirable effect and thus reduce the risk of the development of atherosclerosis in patients subjected to immunosuppressive treatment.
Quality and availability of health care under regional medical programs. From the perspective of the development of personal health service
Authors: D. L. Wilbur
Journal: JAMA (1968)

This conference-workshop provides an excellent opportunity to consider the potential impact of the Regional Medical Programs authorized under Public Law 89-239 on the development of personal health services. It is especially fitting that those most active in conducting this complex and potentially highly beneficial activity be brought together at this time to review planning efforts of the last two years and to consider their translation into operational implementation. In many respects this act is quite extraordinary. Its genesis and promotion as described in a communication in the<i>Atlantic Monthly</i><sup>1</sup>are intriguing. The diverse interpretations among various observers of its long-term objectives suggest many misunderstandings and an uncertain but hopefully great future. The zeal and enthusiasm of the men and women involved in the program—including numerous medical leaders—reflect the dramatic appeal for many individuals of good will and high hopes. The vaguely defined authority of the act seems to many
Thoracic metastases.
Authors: M P Shepherd
Journal: Thorax (1982)

One hundred and four patients are reviewed who were found to have thoracic metastases arising from distant primaries. Ninety lesions were intrapulmonary and the remainder involved other thoracic structures, such as chest wall and pleura. The tissue diagnosis was established in all but eight patients. Cases were included only if review of the histology revealed that both primary and secondary tumours were identical. The chest lesion was the presenting feature of the disease in 21 patients. In the remainder, the interval between treatment of the primary and appearance of the thoracic metastasis varied from a few months to 25 years. Twelve patients had metastatic sarcoma. The remainder had metastases from the gastrointestinal tract (29), from the genitourinary tract (32), from breast primaries (18), and a miscellaneous group (13) which included five instances of malignant melanoma and metastases from adrenal, laryngeal, and thyroid primaries. The metastases were treated surgically in 47 patients. In the light of cell type, availability of nonsurgical methods of treatment, site of metastasis, and survival, an attempt is made to evaluate the place of surgery in the management of thoracic metastatic disease.
Scientific reviewers
Authors: Andrew Schachat, Henry Jampel, Douglas Anderson, James Brandt, Wiley Chambers, Thomas Chang, Susan Day, William Freeman, Glenn Jaffe, Yoshiaki Kitazawa, Ronald Klein, Richard Lewis, Maureen Maguire, Steven Mccormick, Joel Mindel, Arthur Mueller, David Musch, Steven Newman, Joan O'brien, Denis O'day, Roger Steinert, Richard Stone, Alan Sugar, Rohit Varma, Thomas Weingeist, Richard Wormald, Mark Abelson, Gary Abrams, David Abramson, Ingrid Adamsons, Ron Adelman, Natalie Afshari, Lloyd Aiello, P Airaksinen, Al-Abdulla Akpek, Nael Alemayehu, Wondu Alfonso, Eduardo Alio, Jorge Allemann, Norma Allen, Quentin Alward, Wallace Amato, Malena Anand, Rajiv Anderson, Douglas Ando, Akira Antcliff, Richard Antoneli, Celia Apple, David Apte, Rajendra Arellanes-Garcia, Lourdes Arevalo, J Arnold, Anthony Asrani, Sanjay Attebo, Karin Augsburger, James Aung, Claudia Axer-Siegel, Ruth Aylward, George Cantor, Louis Cantore, William Caprioli, Joseph Carones, Francesco Carpineto, Paolo Carvalho-Recchia, Cynthia Cavanagh, H Chaine, Gilles Chalam, K Chalita, Maria Chambers, Wiley Chan, Chi-Chao Chan, Jane Chan, Wai-Man Chandra, Suresh Chang, Tom Chang, Warren Chang-Godinich, Anne Char, Devron Chen, John Chen, Philip Chen, Simon Chen, Teresa Cheng, Ching-Yu Chern, Kenneth Chew, Emily Chiou, Auguste Christman, Ernest Christmas, Nancy Chuang, Elaine Chuck, Roy Chung, Mina Chung, Yu-Mei Chylack, Leo Ciardella, Antonio Cionni, Robert Ciulla, Thomas Clarke, Michael Cockerham, Glenn Cohen, Elisabeth Cohen, Jay Cohen, John Cole, Stephen Coleman, D Congdon, Nathan Connolly, Brian Conway, Mandi Conway, R Cook, Briggs Corbett, James Costa, Sarah Cox, Terry Cremers, Sandra Cunningham, Emmett Dailey, Roger Damato, Bertil Danis, Ronald Datiles, Manuel Davidorf, Jonathan Davis, Janet Jabbur, Nada Jabs, Douglas Jackson, Timothy Jacobson, Samuel Jaffe, Glenn Jampel, Risa Jampel, Robert Javier, Joel Jin, George Johns, Karla Johnson, Chris Johnson, Lenworth Johnson, Mary Johnson, Robert Jonas, Jost Jones, B Jones, Dan Jordan, David Joseph, Annie Joseph, Daniel Juzych, Mark Kadrmas, Eddie Kaiser, Richard Kalina, Robert Kalpadakis, Petros Kaminski, Stephan Kampik, Anselm Kamppeter, Bernd Karcioglu, Zeynel Kashkouli, Mohsen Katowitz, James Katz, Harold Katz, Joanne Kaufman, Paul Kedhar, Sanjay Kempen, John Kennerdell, John Kenyon, Kenneth Kerkhoff, Frank Kerrison, John Kersten, Robert Kertes, Peter Khairallah, Moncef Khandekar, Rajiv Kijlstra, Aize Kim, John Kim, Kwang Kip, Kevin Kiratli, Hayyam Kishi, Shoji Kitazawa, Yoshiaki Kivela, Tero Klein, Barbara Klein, Ronald Kleiner, Robert Klintworth, Gordon Klyce, Stephen Knighton, Robert Koch, Douglas Koh, Sean Kokame, Gregg Kolder, Hansjoerg Kolker, Allan Kompa, Sirpa Kooner, Karanjit Koretz, Jane Kountouras, Jannis Kowalski, Regis Krebs, David Kremmer, Stephan Krueger, Scott Krupin, Theodore Kuchle, Michael Kuhn, Ferenc Kuo, Irene Kuppermann
Journal: Ophthalmology (2004)
Bureau of Legal Medicine and Legislation
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal