tbuckley/cabot-search huggingface dataset:
Abstract 253: HSPB7 is Required for Maintaining the Intercalated Disc Structure to Prevent Cardiac Conduction System Failure in Mouse
Authors: Wern-Chir Liao, Liang-Yi Juo, Yen-Hui Chen, Yu-Ting Yan
Journal: Circulation Research (2017)

HSPB7 is belonged to small heat-shock protein (HSPB) family and considered to function as a co-chaperone, which prevents protein aggregation and maintains protein structure. Single-nucleotide polymorphisms of HSPB7 associated with sporadic cardiomyopathy and heart failure have been identified in human patients. Additionally, HSPB7 is constitutively expressed in heart and rapidly increased in blood plasma after myocardial infarction, suggesting a functional role in the heart. In this study, we found that HSPB7 is highly colocalized with N-cadherin during the assembly and maturation of intercalated disc, suggesting that HSPB7 may involve in organizing and maintaining the cardiac cytoarchitecture. To elucidate the physiological function of HSPB7 in the adult heart, we generated a cardiac-specific inducible HSPB7 knockout mouse. Ablation of HSPB7 in the cardiomyocyte rapidly leads to heart failure, abnormal conduction properties and sudden arrhythmias death. Loss of HSPB7 did not cause significant changes in the organization of contractile proteins in sarcomeres, whereas severe abnormality in the intercalated disc was detected. The expression of connexin 43, a gap-junction protein located at the intercalated disc, was downregulated in HSPB7 knockout cardiomyocytes. Mislocalizations of desmoplakin (desmosomal proteins), and N-cadherin (adherens junction proteins) were also observed in the HSPB7 CKO hearts. Furthermore, filamin C, the interaction protein of HSPB7, was mislocalized and aggregated in HSPB7 mutant cardiomyocytes. The expressivity of the phenotype in the HSPB7 CKO mice is similar to human arrhythmogenic cardiomyopathy patients. Conclusively, we provide the first study characterizing HSPB7 as an intercalated disc protein. Our findings demonstrate that HSPB7 plays an essential role to maintain the structure and function of gap-junction complexes and intercalated disc and has vital implications for human heart disease.
COUNCIL ON PHYSICAL MEDICINE AND REHABILITATION
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Winter Climate of San Remo
Authors: A. H. Hassall
Journal: BMJ (1881)

AT the annual meeting of the British MIedical Association in i88o, I presented to the Section of Medicine a paper on the Winter Climate of San Remo, which was afterwards published in the JOURNAL of the Association for the 2nd October.I have since continued my observa- tions on this subject, and the principal results arrived at I now beg to submit to the Association.The instruments employed were Negretti and Zambra's, corrected at the Royal Kew Observatory; some of these were suspended in a box, with a double roof, and louvred on all sides; this box was placed in the shade, to the north, forty-eight feet above sea-level, thirty from the ground, and about five hundred feet from the sea.The mean day range of temperature, for the six months constituting the winter season i88o-8i; the mean monthly range; the mean maxi- ma and minima temperatures; the mean temperature for the whole season, as well as some other particutlars, are shown in the following table.TABLE I,-Iean ilfontiZ,y Tort/.-ShazdeTemjteratlure.0 l l Month.. 1* Novemrber.*56.!9 6I.5 54-7 57-7 70-3 43-7 5.9 II.8 51.9 48.9 62.8 57.4 December 52.6, 51.6 54-5 65-6 45.0 6.9 I3.7 49.0 44.6 6o.5 5 January.. * 45.3 49-.45-I 46.7 59 33.o 5.5 12.8 42.7 39.0 50.9 46.8 February .. 5o.6 55.4 48.4I 51.5 6I.3 36.o6.i I4.0 45.6 40.9 57.0 5r.3 MIarch . .... 7 58
Long-term survival after routine rescue PTCA for failed thrombolysis is similar to that of successful thrombolysis Philippe G. Steg, Laurent Francois, Bernard lung, Patrick Charlier, Pierre Aubry, Dominique Himbert, Hakim Benamer, Laurent J. Feldman, Jean-Michel Juliard. H�pital Bichat, Paris, France
Journal: Journal of the American College of Cardiology (2001)
Errors in Abstract and Results
Authors: Ji-Hong Liu
Journal: JAMA Oncology (2021)

Thomas Hatschek, MD; Theodoros Foukakis, MD; Judith Bjöhle, MD; Tobias Lekberg, MD; Hanna Fredholm, MD; Ellinor Elinder, MD; Ana Bosch, MD; Gyula Pekar, MD; Henrik Lindman, MD; Aglaia Schiza, MD; Zakaria Einbeigi, MD; Jamila Adra, MD; Anne Andersson, MD; Lena Carlsson, MD; Ann Charlotte Dreifaldt, MD; Erika Isaksson-Friman, MD; Susanne Agartz, MSc; Edward Azavedo, MD; Per Grybäck, MD; Mats Hellström, MSc; Hemming Johansson, MSc; Claudia Maes, MSc; Ioannis Zerdes, MD; Johan Hartman, MD; Yvonne Brandberg, PhD; Jonas Bergh, MD
Drug abuse related to prescribing practices
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply to ‘Epicardial adipose tissue: does it mediate the cardio‐protective effects of sodium–glucose co‐transporter 2 inhibitors in subjects with heart failure?’ Letter regarding the article ‘Impact of epicardial adipose tissue on cardiovascular haemodynamics, metabolic profile, and prognosis in heart failure’
Authors: Nicolò De Biase, Lavinia Del Punta, Nicola Riccardo Pugliese
Journal: European Journal of Heart Failure (2022)
Narcotics and medical practice. Medical use of morphine and morphine-like drugs and management of persons dependent on them
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clínica quirúrgica.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fiber Optic Principles Applied To Colorectal Instruments
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fourth International Symposium on Hyperthermic Oncology
Journal: JNCI Journal of the National Cancer Institute (1983)

Fourth International Symposium on Hyperthermic Oncology JNCI: Journal of the National Cancer Institute, Volume 71, Issue 4, October 1983, Page 878, https://doi.org/10.1093/jnci/71.4.878 Published: 01 October 1983
Journal of Neurosurgery, Chicago
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Resources and Geographic Access to Care for Severe Pediatric Pneumonia in Four Resource-limited Settings
Authors: Suzanne M. Simkovich, Lindsay J. Underhill, Miles A. Kirby, Mary E. Crocker, Dina Goodman, John P. McCracken, Lisa M. Thompson, Anaité Diaz-Artiga, Adly Castañaza-Gonzalez, Sarada S. Garg, Kalpana Balakrishnan, Gurusamy Thangavel, Ghislaine Rosa, Jennifer L. Peel, Thomas F. Clasen, Eric D. McCollum, William Checkley, Vigneswari Aravindalochanan, Dana B. Barr, Vanessa Burrowes, Devan Campbell, Eduardo Canuz, Howard Chang, Yunyun Chen, Marilú Chiang, Maggie L. Clark, Rachel Craik, Victor Dávila-Román, Lisa de las Fuentes, Oscar De Léon, Ephrem Dusabimana, Lisa Elon, Juan Gabriel Espinoza, Irma S. Pineda Fuentes, Savannah Gupton, Meghan Hardison, Stella Hartinger, Steven A. Harvey, Mayari Hengstermann, Phabiola Herrera, Shakir Hossen, Penelope Howards, Lindsay Jaacks, Shirin Jabbarzadeh, Michael A. Johnson, Abigail Jones, Katherine Kearns, Jacob Kremer, Margaret Laws, Patricia M. Lenzen, Jiawen Liao, Amy Lovvorn, Fiona Majorin, Julia McPeek, Rachel M. Meyers, J. Jaime Miranda, Erick Mollinedo, Lawrence Moulton, Krishnendu Mukhopadhyay, Luke Naeher, Abidan Nambajimana, Florien Ndagijimana, Azhar Nizam, Jean de Dieu Ntivuguruzwa, Aris Papageorghiou, Ricardo Piedrahita, Ajay Pillarisetti, Naveen Puttaswamy, Elisa Puzzolo, Ashlinn Quinn, Sarah Rajkumar, Usha Ramakrishnan, Davis Reardon, Joshua Rosenthal, P. Barry Ryan, Zoe Sakas, Sankar Sambandam, Jeremy Sarnat, Sheela Sinharoy, Kirk R. Smith, Kyle Steenland, Damien Swearing, Ashley K. Toenjes, Jean Damascene Uwizeyimana, Viviane Valdes, Amit Verma, Lance Waller, Megan Warnock, Kendra Williams, Wenlu Ye, Bonnie Young
Journal: American Journal of Respiratory and Critical Care Medicine (2021)

Pneumonia is the leading cause of death in children worldwide. Identifying and appropriately managing severe pneumonia in a timely manner improves outcomes. Little is known about the readiness of healthcare facilities to manage severe pediatric pneumonia in low-resource settings.
Prognostic factors associated with survival in patients with pancreatic cancer treated on early phase immune-checkpoint inhibitor clinical trials.
Authors: Rishi Surana, Jane E. Rogers, Graciela M. Nogueras-Gonzalez, David S. Hong, Timothy A. Yap, Jordi Rodon Ahnert, Aung Naing, Robert A. Wolff, Brandon George Smaglo, Funda Meric-Bernstam, Vivek Subbiah, Shubham Pant
Journal: Journal of Clinical Oncology (2022)

577 Background: Immune-checkpoint inhibitors (ICI) have altered the treatment landscape of various solid tumors, but clinical outcomes in patients with pancreatic ductal adenocarcinoma (PDAC) continue to remain dismal. Data are needed to determine prognostic factors of survival to ICI-therapies in pancreatic cancer to better inform future recruitment in immunotherapy-based early clinical trials. Methods: This is a single center, retrospective analysis of patients with PDAC treated with ICI-based therapy as part of phase I trials at MD Anderson Cancer Center. Patients enrolled in a phase I study and treated between 2014 to 2021 were included in the analysis. Descriptive analysis included patient characteristics, progression free survival (PFS) and overall survival (OS). Cox proportional hazards were used to assess associations between patient or tumor characteristics and survival endpoints. Results: One hundred and twenty-two patients were included in this study and received a median of two prior lines of therapy (IQR 1-3). The most commonly utilized ICI were PD-L1 inhibitors (56%) and PD-1 inhibitors (34%). Most patients (96%) received ICI in combination with another investigational agent and 9% of patients received ICI in combination with chemotherapy. The median duration of treatment was 1.38 months (IQR 0.69-2.56). The median PFS was 1.81 months (95% CI 1.78-2.04) and the median OS was 4.83 months (95% CI 4.08-5.92). Univariate analysis showed improved PFS in patients with an albumin of ≥3.5 (1.94 vs 1.32 months, HR 0.29, 95% CI 0.14-0.60, p = 0.001) and Hgb ≥10.5 (1.87 vs 1.81 months, HR 0.63, 95% CI 0.4-0.98, p = 0.039); a longer OS was demonstrated in patients who had lung only metastases (7.92 vs. 4.18 months, HR 0.4, 95% CI 0.21-0.76, p = 0.006), albumin ≥3.5 (5.52 vs. 1.68 months, HR 0.4, 95% CI 0.2-0.8, p = 0.010), and a Hgb ≥10.5 (5.29 vs 4.11 months, HR 0.59, 95% CI 0.38-0.93, p = 0.022). Patients with an ANC/ALC ratio of ≥5 had a shorter OS compared to patients with an ANC/ALC ratio of &lt; 5 (3.98 vs 6.54 months, HR 1.78, 95% CI 1.17-2.69, p = 0.007). Multivariate analysis showed that an albumin ≥3.5 predicted improved PFS (HR 0.41, 95% CI 0.19-0.90, p = 0.026) and an ANC/ALC ratio of ≥5 predicted shorter OS (HR 2.59, 95% CI 1.59-4.19, p &lt; 0.001). Conclusions: Results of this large, single center retrospective study demonstrate that most patients with PDAC treated with ICI based therapies as a part of early phase clinical trials experience disease progression shortly after initiation of therapy and have a limited overall survival. Pretreatment albumin ≥3.5 predicted improved PFS and ANC/ALC ratio ≥5 predicted shorter OS.
Nitrate in drinking water and risk of birth defects: Findings from a cohort study of over one million births in Denmark
Authors: Leslie Thomas Stayner, Anja Søndergaard Jensen, Jörg Schullehner, Vanessa R. Coffman, Betina B. Trabjerg, Jørn Olsen, Birgitte Hansen, Marie Pedersen, Carsten B. Pedersen, Torben Sigsgaard
Journal: The Lancet Regional Health - Europe (2022)

A few studies have reported an increased risk of birth defects (BD) with maternal exposure to nitrate in drinking water. We examined this association in a large cohort study with well-characterized exposure.Danish singletons liveborn to Danish-born parents from 1991-2013 were identified using civil and patient registries (n=1,018,914). Exposure to nitrate was estimated using a spatial model based on national data linked with individual addresses. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using logistic regression.In total, 33,182 cases of BD were identified. Nitrate concentrations were generally well below US and EU standards. We observed an exposure-response relationship (p=0·004) between nitrate during pregnancy and eye BD, and increased risk in the highest exposure group (≥25 mg/L nitrate) (OR: 1·29; 95% CI: 1·00, 1·66). An interaction was observed between maternal age and continuous nitrate exposure for nervous system BD (p<0·001) indicating an increased risk among mothers <25 years-of-age (OR for 10 mg/L (OR10): 1·20; 95% CI: 1·06, 1·35). An interaction (p<0.01) with maternal age and continuous nitrate exposure was also observed for ear, face, and neck BD indicating an increased risk among babies born to mothers <25 years-of-age (OR10: 1·35; 95% CI: 1·11, 1·66). There was evidence of an inverse exposure-response relationship for any, digestive system, female genital, and urinary BD.Our study is the first to report an association between nitrate and eye BD and BD of the ear, face, and neck. It also provides support to prior reports of increased risk of nervous system BD.This study was supported by a grant from the United States National Institute of Environmental Health Sciences (R01 ES027823-01A1).
Association of an immunosuppressive macrophage transcriptional signature derived from peripheral blood macrophages with gastric cancer prognosis.
Authors: Kevin Sullivan, Kelly Mahuron, Haiqing Li, Isaac Benjamin Paz, Yuman Fong, Yanghee Woo
Journal: Journal of Clinical Oncology (2022)

354 Background: Gastric cancer (GC) is the fourth most common cause of cancer death worldwide. Studies have shown an association of higher macrophage density in the tumor microenvironment with worse outcomes in GC. The presence of M2 specific gene signatures in the peripheral blood of cancer patients are associated with poor prognosis. However, it is unknown whether these immunosuppressive M2 markers are prognostic when found in the primary GC tumors. Methods: Based on previously published differential gene expression profiles that distinguish M1 versus M2 macrophages in the peripheral blood, we used the UCSC Xena webtool to analyze the TCGA Stomach Cancer cohort for tumor-associated immune signatures for their prognostic value. We excluded null entries, normal tissue, and entries with incomplete data. We investigated both M1- and M2-macrophage signatures (M1 signature: CCR7, IL2RA, CXCL11, CCL19, CXCL10, PLA1A, PTX3 and M2 signature: MRC1, MS4A4A, CD36, CCL13, CCL18, CCL23, SLC38A6, FGL2, FN1, MAF); as well as a T cell cytolytic signature defined by genes with cytolytic functions ( GZMA, GZMB, GZMH, GZMM, PRF1). We analyzed the impact of transcriptional gene expression with relation to stage, histological subtype, overall survival (OS), and disease free interval (DFI). The UCSC Xena webtool uses log-rank test to compare Kaplan-Meier curves. Results: A total of 341 entries were analyzed with age ranging from 30-90 and 39.4% female. Increased CD168 expression was associated with increased stage of GC (p = 0.017). Higher expression of the M2-macrophage signature was associated with diffuse type adenocarcinoma and mucinous type intestinal adenocarcinoma, compared to tubular and papillary type intestinal adenocarcinoma (p &lt; 0.001). In addition, higher M2-macrophage signature expression was associated with late stage (Stage II or above) compared to early stage (stage I) (p = 0.022). A low M2-macrophage signature was associated with improved 5-year OS (p = 0.029), and a significantly improved 5-year DFI (p = 0.042). CD8A, cytolytic T cell signature, and M1 macrophage signature were not associated with stage of disease or survival. Conclusions: A transcriptional signature derived from peripheral blood immunosuppressive M2 macrophage phenotype is found in GC primary tumors and associated with higher pathologic staging and with worse outcomes. These M2 defining molecular biomarkers of GC has the potential to serve as targets of novel immune-therapeutic strategies.