tbuckley/cabot-search huggingface dataset:
Phase 1 First-in-Human Trial of AMV564, a Bivalent Bispecific (2x2) CD33/CD3 T-Cell Engager, in Patients with Relapsed/Refractory Acute Myeloid Leukemia (AML)
Authors: Peter Westervelt, Gail J. Roboz, Jorge E. Cortes, Hagop M. Kantarjian, Sangmin Lee, Michael P. Rettig, Tae H. Han, Jeanmarie Guenot, Eric J. Feldman, John F. DiPersio
Journal: Blood (2018)
<i>A Text-Book of Pathology in Relation to Mental Diseases.</i>By W. Ford Robertson, M. D., Pathologist to the Scottish Asylums; Formerly Pathologist to the Royal Edinburgh Asylum. Illustrated with sixteen lithographic plates in black and in colors and thirteen engravings. (Edinburgh, William F. Clay 18 Teviot Place, 1900.)
Journal: American Journal of Psychiatry (1901)
Noise in the laboratory.
Journal: BMJ (1970)

MEDICAL JOL lonely, unhappy women with few or no friends in the block, and their children spent most of their days inside the flat.There was no place for them to play outside safe enough for the mother to leave them unsupervised.What such families wanted was "a place of our own with a back garden."Families with teenage or grown-up children were much more content.This report adds further weight to the case against tall flats as a solution to housing problems.D. M. Fanning2 has shown that flat dwellers are unhealthier than families who live in houses, and he, too, suggested that they were unhappier as well.The N.S.P.C.C. study found that balcony flats seem to
X-Ray Seminar Number 14
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P271: Women’s Reproductive History and Peripheral Arterial Disease in Late Life: The San Diego Population Study
Authors: Yamnia I Cortes, Nisha Parikh, Matthew A Allison, Michael H Criqui, Natalie Suder, Emma Barinas-Mitchell, Christina L Wassel
Journal: Circulation (2018)

Background: Total population burden of peripheral artery disease (PAD) is higher for women than men age ≥40 years. Reproductive factors (e.g., early menarche, parity, early menopause) have been linked with later-life cardiovascular risk in women, but whether they influence PAD has been understudied. Objective: To evaluate associations between reproductive factors with later-life ankle-brachial index (ABI), femoral artery intima-media thickness (fIMT), and femoral plaques. Methods: Cross-sectional analysis of 707 multiethnic women who participated in a follow-up exam of the San Diego Population Study conducted in 2007-2011. Reproductive exposures included age at menarche, number of live births, age at menopause, surgical menopause, and history of oral contraceptive use. Dependent variables were ABI and Doppler ultrasound measurements of common fIMT and any femoral plaque presence. We performed multiple linear and logistic regression adjusting for age, race/ethnicity, and cardiometabolic factors. Since 30% (n=201) of women reported surgical menopause, we tested for interactions with reproductive factors and stratified by menopause type (natural vs. surgical). Results: Women were on average 70.6 years old (SD=9.6) and 56% were White. There were no significant associations in the overall sample after adjusting for covariates. We found interactions between surgical menopause and oral contraceptive use (p=0.03) for ABI, and with parity (p=0.05) and age at menopause (p=0.05) for fIMT. Among women with natural menopause, oral contraceptive use was associated with higher ABI (β:0.03, p=0.007) and older age at menopause was related to greater fIMT (β:0.009, p=0.06) ( Table 1 ). Among women with surgical menopause, parity (0 vs. 2) was marginally associated with greater fIMT (β:0.33, p=0.07). Conclusions: Findings suggest that reproductive history may be associated with later-life development of PAD in women. Studies are necessary to confirm findings and examine pregnancy-related exposures in relation to PAD.
Comments on Intraoperative Molecular Imaging for Localizing Nonpalpable Tumors—Reply
Authors: Gregory T. Kennedy, Sunil Singhal
Journal: JAMA Surgery (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Corrections
Journal: BMJ (2021)

In this practice pointer on care of men with BRCA variants (doi:; ), the introduction has been changed to read "We refer to men but this article may also apply to some transgender and non-binary people: their risk profiles and recommended care should be appropriately individualised."This change was made to include the range of patients to whom the article might apply.Also in this article, the legends to figures 1(a) and 1(b) have been changed to make clear that in figure 1(b) "Risk of female and male breast cancer associated with cancer-predisposing BRCA variants" the cumulative cancer risks are shown on different scales.
Cell membrane-anchored and tumor-targeted IL-12 (attIL12)-T cell therapy for eliminating large and heterogeneous solid tumors
Authors: Jiemiao Hu, Qing Yang, Wendong Zhang, Hongwei Du, Yuhui Chen, Qingnan Zhao, Long Dao, Xueqing Xia, Fowlkes Natalie Wall, Zhongting Zhang, Kris Mahadeo, Richard Gorlick, S Kopetz, Gianpietro Dotti, Shulin Li
Journal: Journal for ImmunoTherapy of Cancer (2022)

Adoptive T-cell transfer has become an attractive therapeutic approach for hematological malignancies but shows poor activity against large and heterogeneous solid tumors. Interleukin-12 (IL-12) exhibits potent antitumor efficacy against solid tumors, but its clinical application has been stalled because of toxicity. Here, we aimed to develop a safe approach to IL-12 T-cell therapy for eliminating large solid tumors.We generated a cell membrane-anchored IL-12 (aIL12), a tumor-targeted IL-12 (ttIL12), and a cell membrane-anchored and ttIL-12 (attIL12) and a cell membrane-anchored and tumor-targeted ttIL-12 (attIL12) armed T cells, chimeric antigen receptor-T cells, and T cell receptor-T (TCR-T) cells with each. We compared the safety and efficacy of these armed T cells in treating osteosarcoma patient-derived xenograft tumors and mouse melanoma tumors after intravenous infusions of the armed T cells.attIL12-T cell infusion showed remarkable antitumor efficacy in human and mouse large solid tumor models. Mechanistically, attIL12-T cells targeted tumor cells expressing cell-surface vimentin, enriching effector T cell and interferon γ production in tumors, which in turn stimulates dendritic cell maturation for activating secondary T-cell responses and tumor antigen spreading. Both attIL12- and aIL12-T-cell transfer eliminated peripheral cytokine release and the associated toxic effects.This novel approach sheds light on the safe application of IL-12-based T-cell therapy for large and heterogeneous solid tumors.
Atopic dermatitis, psychiatric disorders and medication use in childhood
Journal: British Journal of Dermatology (2021)

Journal Article Atopic dermatitis, psychiatric disorders and medication use in childhood Get access British Journal of Dermatology, Volume 185, Issue 1, 1 July 2021, Page e13, https://doi.org/10.1111/bjd.20451 Published: 01 July 2021
Transactions of the American Orthopedic Association
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Canopy Homolog 2 contributes to liver oncogenesis by promoting unfolded protein response–dependent destabilization of tumor protein P53
Authors: Feng Hong, Ching Ying Lin, Jingyue Yan, Yizhou Dong, Yuli Ouyang, Doyeon Kim, Xiaoli Zhang, Bei Liu, Shaoli Sun, Wei Gu, Zihai Li
Journal: Hepatology (2022)

Abstract Backgroud and Aims Abnormalities in the tumor protein P53 ( p53 ) gene and overexpression of mouse double minute 2 homolog (MDM2), a negative regulator of p53, are commonly observed in cancers. p53 destabilization is regulated by endoplasmic reticulum (ER) stress and unfolded protein response (UPR) in cancer. However, the mechanisms remain enigmatic. Canopy homolog 2 (CNPY2) is a key UPR initiator that primarily involved in ER stress and is highly expressed in the liver, but its functional role in regulating liver carcinogenesis is poorly understood. Therefore, we aimed to investigate the role of CNPY2 in hepartocarcinogenesis through URP‐dependent p53 destabilization. Approach and Results Here, we showed that CNPY2 expression is up‐regulated in HCC and negatively correlated with survival rate in liver cancer patients. Deletion of Cnpy2 obliterates diethylnitrosamine (DEN)‐induced HCC in mice. Mechanistic studies demonstrated that CNPY2 binds and prevents ribosome proteins from inhibiting MDM2 and enhances the UPR activity of protein kinase RNA‐like endoplasmic reticulum kinase and inositol‐requiring transmembrane kinase endoribonuclease‐1α, leading to p53 destabilization and cell‐cycle progression. In addition, transcriptome analyses uncovered that CNPY2 is also required for DEN‐induced expression of oncogenes, including c‐Jun and fibroblast growth factor 21. Intratumoral injection of nanoparticle‐based CRISPR single‐guide RNA/CRISPR‐associated protein 9 mRNA against Cnpy2 has antitumor effects in HCC. Conclusions These findings demonstrate that CNPY2 is crucial for liver oncogenesis through UPR‐dependent repression of p53 and activation of oncogenes, providing insights into the design of a therapeutic target for HCC.
Changes in primary angioplasty and effect on in-hospital and two-year outcomes from 1996?1998 Vijay G. Kalaria, Imran Chaudhary, Seth Jacobson, Richard M. Pomerantz, Christopher J. Cove, Lori Caufield, Frederick S. Ling, Donald E. Cutlip. University of Rochester Medical Center, Rochester, NY
Journal: Journal of the American College of Cardiology (2001)
Diagnostic and therapeutic technology assessment. Enhanced computed tomography in head trauma
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Letter: Antipsychiatrists and ECT.
Authors: W Oakley, David Pyke, Keith Lewes
Journal: BMJ (1976)

Antipsychiatrists and ECTSIR,-Your leading article (4 October, p 1) seeks to look dispassionately at an emotion- charged problem in medical practice but, in doing so, repeats errors which it hopes to rectify: "The very words shock and con-
H1-Antihistamines Reduce the Risk of Hepatocellular Carcinoma in Patients With Hepatitis B Virus, Hepatitis C Virus, or Dual Hepatitis B Virus-Hepatitis C Virus Infection
Authors: Yu-Chuan Shen, Hui-Ching Hsu, Tzu-Min Lin, Yu-Sheng Chang, Li-Fang Hu, Lung-Fang Chen, Sheng-Hong Lin, Pei-I. Kuo, Wei-Sheng Chen, Yi-Chun Lin, Jin-Hua Chen, Yu-Chih Liang, Chi-Ching Chang
Journal: Journal of Clinical Oncology (2022)

H1-antihistamines (AHs) may exert protective effects against cancer. This study investigated the association of AH use with the risk of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV), hepatitis C virus (HCV), or dual HBV-HCV virus infection.Patients with HBV, HCV, or dual HBV-HCV infection were enrolled from Taiwan's National Health Insurance Research Database and examined for the period from January 1, 2006, to December 31, 2015. We used the Kaplan-Meier method and Cox proportional hazards regression to evaluate the association between AH use and HCC risk.We included patients with HBV infection (n = 521,071), HCV (n = 169,159), and dual HBV-HCV (n = 39,016). Patients with HBV, HCV, or dual virus infection who used AHs exhibited significantly lower risk of HCC relative to patients who did not use AH, with their adjusted hazard ratio being 0.489 (95% CI, 0.455 to 0.524), 0.484 (95% CI, 0.450 to 0.522), and 0.469 (95% CI, 0.416 to 0.529), respectively. Furthermore, there was a dose-response relationship between AH use and the risk of HCC in the HBV cohort. The adjusted hazard ratios were 0.597 (95% CI, 0.530 to 0.674), 0.528 (0.465 to 0.600), 0.470 (0.416 to 0.531), and 0.407 (0.362 to 0.457) for AH use of 28-42, 43-63, 64-119, and ≥ 120 cumulative defined daily doses, respectively, relative to no AH use. Additionally, there was also a dose-response relationship between AH use and the risk of HCC in the HCV and dual HBV-HCV cohorts.AH use may reduce the risk for HCC among patients with HBV, HCV, or dual infection in a dose-dependent manner. Further mechanistic research is needed.
Increased Impact of Air Pollution on Lung Function in Preterm versus Term Infants: The BILD Study
Authors: Fabienne Decrue, Olga Gorlanova, Yasmin Salem, Danielle Vienneau, Kees de Hoogh, Amanda Gisler, Jakob Usemann, Insa Korten, Uri Nahum, Pablo Sinues, Sven Schulzke, Oliver Fuchs, Philipp Latzin, Martin Röösli, Urs Frey, Pinelopi Anagnostopoulou, Carmen Casaulta, Kees de Hoogh, Fabienne Decrue, Urs Frey, Oliver Fuchs, Amanda Gisler, Olga Gorlanova, Insa Korten, Johanna Kurz, Claudia Kühni, Philipp Latzin, Loretta Müller, Uri Nahum, Sylvia Nyilas, Marc-Alexander Oestreich, Elena Proietti, Kathryn Ramsey, Martin Röösli, Yasmin Salem, Andràs Soti, Jakob Usemann, Danielle Vienneau, Corin Willers, Sophie Yammine
Journal: American Journal of Respiratory and Critical Care Medicine (2021)

Rationale: Infants born prematurely have impaired capacity to deal with oxidative stress shortly after birth. Objectives: We hypothesize that the relative impact of exposure to air pollution on lung function is higher in preterm than in term infants. Methods: In the prospective BILD (Basel-Bern Infant Lung Development) birth cohort of 254 preterm and 517 term infants, we investigated associations of particulate matter ⩽10 μm in aerodynamic diameter (PM10) and nitrogen dioxide with lung function at 44 weeks' postconceptional age and exhaled markers of inflammation and oxidative stress response (fractional exhaled nitric oxide [FeNO]) in an explorative hypothesis-driven study design. Multilevel mixed-effects models were used and adjusted for known confounders. Measurements and Main Results: Significant associations of PM10 during the second trimester of pregnancy with lung function and FeNO were found in term and preterm infants. Importantly, we observed stronger positive associations in preterm infants (born 32-36 wk), with an increase of 184.9 (95% confidence interval [CI], 79.1-290.7) ml/min [Formula: see text]e per 10-μg/m3 increase in PM10, than in term infants (75.3; 95% CI, 19.7-130.8 ml/min) (pprematurity × PM10 interaction = 0.04, after multiple comparison adjustment padj = 0.09). Associations of PM10 and FeNO differed between moderate to late preterm (3.4; 95% CI, -0.1 to 6.8 ppb) and term (-0.3; 95% CI, -1.5 to 0.9 ppb) infants, and the interaction with prematurity was significant (pprematurity × PM10 interaction = 0.006, padj = 0.036). Conclusions: Preterm infants showed significantly higher susceptibility even to low to moderate prenatal air pollution exposure than term infants, leading to increased impairment of postnatal lung function. FeNO results further elucidate differences in inflammatory/oxidative stress response when comparing preterm infants with term infants.
Transcatheter occlusion of the left atrial appendage with a novel implanted device: First experience Edward P. Gerstenfeld, Toshiko Nakai, Paul B. Sparks, Yoshinaru Goseki, Clegg Honeycutt, Richard Chen, Jonathan J. Langberg, Michael D. Lesh. University of California, San Francisco, CA, Emory University Hospital, Atlanta, GA
Journal: Journal of the American College of Cardiology (2001)
Medical Journal of Australia, Sydney
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P217: Parathyroid Hormone is Not Independently Associated With Cognitive Decline: 20 Year Follow-up From the Atherosclerosis Risk in Communities (ARIC) Study
Authors: Samuel M Kim, Di Zhao, Andrea L Schneider, Sai Krishna Korada, Pamela L Lutsey, Eliseo Guallar, Alvaro Alonso, B. Gwen Windham, Rebecca F Gottesman, Erin D Michos
Journal: Circulation (2017)

Background: Little is known about the role of parathyroid hormone (PTH) in cognitive decline. Elevated PTH may contribute to cognitive impairment and dementia by mechanisms of endothelial dysfunction, increased vascular stiffness, hypertension, and atherosclerosis, as well as via small vessel cerebral disease. We hypothesized that elevated PTH levels will be independently associated with 20-year cognitive decline in a large population-based cohort study. Methods: We studied 12,964 middle-aged white and black ARIC participants without history of prior stroke who had serum PTH levels and cognitive function testing measured in 1990-92 (baseline) and repeat cognitive testing at up to 2 follow-up visits in 1996-98 and 2011-13. The cognitive tests included the Delayed Word Recall, Digit Symbol Substitution, and Word Fluency tests, which were summed as a global z score. Using mixed-effects models, we compared the relative decline in global cognitive score between each of the top three quartiles of PTH levels to the reference bottom quartile. Time since baseline was modeled by using a linear spline with a knot at 6 years. We adjusted for demographic variables, education, vascular risk factors, and calcium, phosphorous, and vitamin D levels. We imputed missing covariates and follow-up cognitive data using multiple imputation by chained equations (MICE) methods to account for attrition during study follow-up. Results: The mean (SD) age of our cohort was 57(6) years, 57% were women, and 24% black race. There was no cross-sectional association of elevated PTH with cognitive global Z score at baseline (all p&gt;0.05). Over a median of 20.7 years, participants in each PTH quartile showed decline in cognitive function ( Table Part A ). However, cognitive decline was not steeper in participants with PTH levels in the higher quartiles than participants with the lowest PTH levels (all p&gt;0.05). [ Table Part B ]. Conclusions: Our work does not support an independent influence of PTH on cognitive decline in this biracial population-based cohort study.
Abnormal glucose metabolism in diastrophic dwarfism
Authors: R. K. Sharma
Journal: JAMA (1972)

A case study details the clinical, biochemical, and roentgenographic findings in a diastrophic dwarf. The clinical findings were scoliosis and lordosis of the spine, club feet, cleft palate, dysplastic hips, and flexion contractures of knee joints and short extremities. Biochemical abnormalities observed were high cholesterol level, abnormal glucose tolerance, low growth hormone levels, and abnormal excretion of xanthurenic and kynurenic acids following tryptophan loading.