POS0019 PREDICTORS OF SUSTAINED 6 MONTHS REMISSION AND FLARE IN PATIENTS WITH POLYMYALGIA RHEUMATICA
Authors: C. Perricone, E. Fiumicelli, G. Cafaro, R. Bursi, R. Ilenia, E. Bartoloni Bocci, R. Gerli
Journal: Annals of the Rheumatic Diseases (2021)

Background: Polymyalgia rheumatica (PMR) is a typical inflammatory disease of the elderly. The mainstay of treatment is usage of oral glucocorticoids (GC) usually leading to a dramatic response. However, long-term treatment is often required. In some instances, remission cannot be achieved and disease flares can occur. To date, few papers investigated the predictive factors of response to GC therapy suggesting a role for weight, elevated plasma viscosity and C-reactive protein (CRP). Moreover, there are no data on predictor factors of disease flares after 6 months of sustained remission. Objectives: To evaluate the factors predictive of sustained 6 months remission and of flare in patients with PMR. Methods: We evaluated clinical data from 137 PMR patients treated with GC for more than 6 months between September 2002 and June 2020. Patients were evaluated at baseline, re-evaluated at 1 month and after 3 months and then at least every 3 months. We analyzed the differences between patients who achieved remission within 6 months of diagnosis, who maintained it for at least 6 months, and patients who did not. Remission was defined as 1) the absence of clinical symptoms, 2) &lt;7.5 mg / day of prednisone equivalents and 3) negativity of ESR and CRP. Patients treated with methylprednisolone were excluded from the analysis. Results: Among the 137 patients (baseline F68: M69, mean age ± SD 74.5±6.6 years, mean ESR ± SD 49.9±27.7 mm/h, mean CRP ± SD 6.1±11.4 mg/dl), 57 achieved remission at 6 months (41.6%), and after this period, another 47 went into remission for a total of 104 patients (75.9%). The months required to achieve remission averaged 6.4 ± 3. No differences were observed between patients who achieved remission and patients who did not regarding age, sex, CRP, starting dose of GC, anti-CCP and rheumatoid factor. The ESR at baseline was higher in patients who did not achieve remission (58.1±33.4 mm/h) than in patients who achieved it (46±24.8 mm/h, p=0.06). ESR at baseline correlated with the time needed to reach normalization of both ESR and CRP (p=0.01, Figure 1). Thirty-six of 104 patients (34.6%) had a disease flare after a mean of 6.1±2.7 months of remission. The mean GC intake at flare was 2.8±3 mg/day. Only 15/36 (41.6%) patients were able to withhold GCs after flare, compared with 48/68 (70.5%) patients who achieved remission and did not experience flare. There were no significant differences in any analyzed parameters between patients who experienced flares and those who did not, including ESR and CRP values at baseline (50.3±26.7 mm/h and 6.8±12.1 mg/dl, respectively). A higher percentage of patients who did not achieve remission experienced flare than patients who went into remission (p=0.009). Conclusion: Achieving complete remission at 6 months occurs in a consistent percentage of patients with PMR. Despite this, a significant percentage of patients may need prolonged steroid treatment and may experience flare, even after 12 months of follow-up. Remission at 6 months is likely to be a good predictor of remission at 12 months, as already reported in recent studies (1, 2). Elevated ESR at diagnosis appears to be a negative predictor for remission at 6 months. Patients who achieve complete remission are less likely to develop flare. True remission should coincide with the discontinuation of steroid treatment; in fact, the maintenance of steroid therapy, even at low doses, is predictive of the development of flare. References: [1]Hattori K, et al. Int J Rheum Dis. 2020 [2]Camellino D, et al. Nat Rev Rheumatol. 2020 Figure 1. Disclosure of Interests: Carlo Perricone Speakers bureau: BMS, Lilly, Celgene, UCB, Abbvie, Pfizer, Sanofi, Accord, Novartis, Elena Fiumicelli: None declared, Giacomo Cafaro: None declared, Roberto Bursi: None declared, Ricucci Ilenia: None declared, Elena Bartoloni Bocci: None declared, Roberto Gerli: None declared.