tbuckley/cabot-search huggingface dataset:
Interaction of neuropeptide Y and the sympathetic nervous system in vascular control in man.
Authors: JClarke, NBenjamin, SLarkin, DWebb, AMaseri, GDavies
Journal: Circulation (1991)

BACKGROUNDThere is increasing evidence that neuropeptide Y (NPY) contributes to the autonomic control of the circulation. NPY coexists with noradrenaline in perivascular nerve terminals, may be released during sympathetic stimulation, and is a potent constrictor of the human coronary circulation and other vascular beds. In vitro studies show that NPY can act either directly on vascular smooth muscle or indirectly by modulation of the presynaptic release or the postsynaptic actions of noradrenaline. It is unclear to what extent these mechanisms operate in vivo.METHODS AND RESULTSThe effect on forearm blood flow of intra-arterial NPY was studied in six volunteers during coinfusion of noradrenaline and during reflex sympathetic stimulation induced by lower-body negative pressure. NPY alone induced a dose-dependent reduction of forearm blood flow in all subjects studied, to a maximum of 49 +/- 6.1%. The reduction of flow during infusion of noradrenaline alone was 42 +/- 8%. The response to noradrenaline was u...
Quality in Endoscopic Retrograde Cholangiopancreatography: Adverse Events and Their Predictive Factors
Authors: F de Sousa Damião, C Noronha Ferreira, M Moura, C Freitas, P Costa, R Rios Crespo, J Rita Carvalho, R Palma, A Marques, A Almeida, L Carrilho Ribeiro, R Tato Marinho
Journal: Endoscopy (2021)

Aims To report incidence of adverse events and identify risk factors for post-ERCP pancreatitis (PEP), bleeding, cholangitis, cholecystitis and perforation.
Flow-induced constriction and dilation of cerebral resistance arteries.
Authors: J LGarcia-Roldan, J ABevan
Journal: Circulation Research (1990)

Rabbit pial resistance artery segments were cannulated at both ends so they could be perfused with physiological saline solution and were maintained in a tissue bath of the same solution. Both were kept at 37 degrees C and equilibrated with 95% O2 and 5% CO2. Perfusion pressure and flow were independently controlled by two servo-controlled pumps, and changes in the diameter of the segment were registered by an automated video technique. In the absence of flow, these segments maintained their diameter when intraluminal pressure was changed over the range 30-90 mm Hg. When intraluminal pressure was low (30 mm Hg), flow at 20 microliters/min caused dilation. This is half the rate of flow that causes a maximum flow-induced change under the conditions of these experiments. When pressure was high (90 mm Hg), the same flow rate caused constriction. Both responses usually continued as long as flow was maintained. Thus, flow-induced changes in the diameter of this artery can be initiated and are usually maintained...
Fetal Erythropoiesis Is Defective in Rpl11 Heterozygous Mice and Increases in Severity in Young Animals
Authors: Dolly Thomas, Cailin Joyce, Robert A. Redd, Bertil Glader, Steven Ellis, Donna S. Neuberg, Meaghan McGuinness, Colin A. Sieff, Carl D. Novina
Journal: Blood (2017)
Ventricular volume characteristics in double-inlet left ventricle before and after septation.
Authors: MNakazawa, HAotsuka, YImai, HKurosawa, SFukuchi, GSatomi, ATakao
Journal: Circulation (1990)

Septation is one of the surgical choices for double-inlet left ventricle, yet postoperative hemodynamics have not been well defined. We studied ventricular volume characteristics in 10 patients with double-inlet left ventricle before and after septation. Preoperative end-diastolic volume (EDV) of the ventricle was 291 +/- 111% (+/- SD) of normal and ejection fraction (EF) was 0.59 +/- 0.07. Postoperatively, EDV of the right-sided ventricle (RV) was 82 +/- 24%, and EDV of the left-sided ventricle (LV) was 153 +/- 41%. Ejection fraction of the RV was 0.77 +/- 0.10, and LVEF was 0.49 +/- 0.13. On the short-axis view of two-dimensional echocardiography, fractional change of the cross-sectional area was 0.65 +/- 0.16 for the RV and 0.23 +/- 0.11 for the LV. Fractional shortening of the septum-to-ventricular free wall axis was 0.51 +/- 0.17 in the RV and -0.05 +/- 0.09 in the LV. Analysis of the curvature of the new septum during cardiac cycle on two-dimensional echocardiography revealed that the septum shifted...
Wolff-Parkinson-White syndrome in children: electrophysiologic and pharmacologic characteristics.
Authors: P CGillette, AGarson, J DKugler
Journal: Circulation (1979)

Intracardiac electrophysiologic studies were performed on 28 infants and children, ages 1 month to 18 years, with the Wolff-Parkinson-White syndrome to try to determine 1) the electrophysiologic characteristics of the accessory connection and 2) the mechanisms of associated supraventricular dysrhythmias. Although the antegrade refractory periods of the normal conduction system were shorter than those found in adults, those of the accessory connection were slightly longer. Reciprocating supraventricular tachycardia (SVT), which had been a clinical problem in 26 of 28, could be induced in the laboratory in all 26 subjects. The mechanism involved reentry with antegrade conduction through the atrioventricular (AV) node and retrograde through the accessory connection in 22. Eleven of these 22 had a wide QRS during tachycardia due to a bundle branch block. Three other subjects had wide QRS tachycardia, but the mechanism involved antegrade conduction through the accessory connection and retrograde through the AV...
Serum Lp(a) level as a predictor of vein graft stenosis after coronary artery bypass surgery in patients.
Authors: H FHoff, G JBeck, C ISkibinski, GJürgens, JO'Neil, JKramer, BLytle
Journal: Circulation (1988)

Although the serum lipoprotein fraction Lp(a) has been associated with coronary artery atherosclerosis, its relationship to narrowing of saphenous vein grafts has not previously been elucidated. We therefore measured serum Lp(a) levels in 167 symptomatic patients undergoing cardiac catheterization who had had coronary artery bypass surgery 0.7 to 14.3 years earlier. Lp(a), total cholesterol, and total triglyceride levels were compared with the degree of saphenous vein graft stenosis to test for any association. Serum Lp(a) levels were significantly associated with the degree of stenosis of saphenous vein grafts (r = .24, p = .002). Mean Lp(a) levels (mg/dl) in the 135 patients with stenosis were almost double (32.0 +/- 32.7, mean +/- SD) those in the 32 patients with no graft stenosis (16.7 +/- 22.6; p = .002). Graft stenosis was not associated with previous myocardial infarction, hypertension, obesity, diabetes, or smoking. Serum cholesterol levels (mg/dl) were slightly higher in the stenosis group (251....
Ventilatory Variables and Mechanical Power in Patients with Acute Respiratory Distress Syndrome
Authors: Eduardo L. V. Costa, Arthur S. Slutsky, Laurent J. Brochard, Roy Brower, Ary Serpa-Neto, Alexandre B. Cavalcanti, Alain Mercat, Maureen Meade, Caio C. A. Morais, Ewan Goligher, Carlos R. R. Carvalho, Marcelo B. P. Amato
Journal: American Journal of Respiratory and Critical Care Medicine (2021)

Rationale: Mortality in acute respiratory distress syndrome (ARDS) has decreased after the adoption of lung-protective strategies. Lower Vt, lower driving pressure (ΔP), lower respiratory rates (RR), and higher end-expiratory pressure have all been suggested as key components of lung protection strategies. A unifying theoretical explanation has been proposed that attributes lung injury to the energy transfer rate (mechanical power) from the ventilator to the patient, calculated from a combination of several ventilator variables.Objectives: To assess the impact of mechanical power on mortality in patients with ARDS as compared with that of primary ventilator variables such as the ΔP, Vt, and RR.Methods: We obtained data on ventilatory variables and mechanical power from a pooled database of patients with ARDS who had participated in six randomized clinical trials of protective mechanical ventilation and one large observational cohort of patients with ARDS. The primary outcome was mortality at 28 days or 60 days.Measurements and Main Results: We included 4,549 patients (38% women; mean age, 55 ± 23 yr). The average mechanical power was 0.32 ± 0.14 J · min-1 · kg-1 of predicted body weight, the ΔP was 15.0 ± 5.8 cm H2O, and the RR was 25.7 ± 7.4 breaths/min. The driving pressure, RR, and mechanical power were significant predictors of mortality in adjusted analyses. The impact of the ΔP on mortality was four times as large as that of the RR.Conclusions: Mechanical power was associated with mortality during controlled mechanical ventilation in ARDS, but a simpler model using only the ΔP and RR was equivalent.
Enrichment, solubilization, and partial characterization of digitonin-solubilized muscarinic receptors derived from canine ventricular myocardium.
Authors: A SManalan, D KWerth, L RJones, A MWatanabe
Journal: Circulation Research (1983)

The subcellular distribution of cardiac muscarinic receptors was defined in canine ventricular myocardium, and receptors were solubilized from subcellular fractions enriched in muscarinic receptor content. The subcellular location of muscarinic receptors in cardiac tissue was determined by measurement of the distribution of [3H](+/-)quinuclidinyl benzilate-binding activity in particulate fractions isolated from canine ventricular myocardium. Based upon excellent correlation between [3H](+/-)quinuclidinyl benzilate binding and activity of the sarcolemmal Na+,K+-ATPase throughout the subcellular fractions, muscarinic receptors appeared to be localized to sarcolemma in canine ventricular myocardium. Therefore, membrane fractions enriched in sarcolemma were used as a source of cardiac muscarinic receptors for solubilization. Treatment of membrane vesicle fractions with digitonin (0.6%) resulted in solubilization of [3H](+/-)quinuclidinyl benzilate-binding activity with an extraction yield of 25-35%. Criteria ...
慢性腎不全を合併し,冠状動脈造影した患者におけるバルサルタン心-腎保護(VAL-CARP)試験 論理的根拠およびデザイン
Authors: Ikeda Naofumi, Nishimura Shigeyuki, Kyo Shunei, Komiyama Nobuyuki, Matsumoto Kazuo, Inoue Tsutomu, Suzuki Hiromichi
Journal: Circulation (2006)
Stalking the Diagnosis
Authors: Daniel J. Minter, Megan Richie, Priya Kumthekar, Harry Hollander
Journal: New England Journal of Medicine (2021)

A 22-year-old man presented with progressive neurologic decline. A year before presentation, painless vision loss had occurred in the left eye, followed by the right eye. During the next 4 to 6 months, diffuse numbness, limb stiffness, whole-body weakness, and urinary incontinence had developed.
Left heart volume characteristics following ventricular septal defect closure in infancy.
Authors: DCordell, T PGraham, G FAtwood, R CBoerth, R JBoucek, H WBender
Journal: Circulation (1976)

Left ventricular and left atrial volume, left ventricular ejection fraction, and left ventricular muscle mass were determined preoperatively and postoperatively in 13 patients who underwent surgical closure of ventricular septal defects in the first two years of life. Left ventricular end-diastolic volume and systolic output averaged 255 +/- 19% (+/- SEM) and 240 +/- 19% of normal, respectively, before operation but fell to within normal limits postoperatively. Left ventricular ejection fraction was normal preoperatively (100 +/- 4% of normal) and remained so after correction (106 +/- 3%, NS). Left ventricular mass was mildly elevated at the preoperative catheterization (271 +/- 21%) and decreased significantly following repair (P less than 0.001). However, the postoperative left atrial volume (147 +/- 14%) remained abnormal (P greater than 0.05). These data suggest that when early surgical closure of a ventricular septal defect is necessary because of failure of medical management, good results with rega...
Eruptive Calcified Nodules as a Potential Mechanism of Acute Coronary Thrombosis and Sudden Death
Authors: Sho Torii, Yu Sato, Fumiyuki Otsuka, Frank D. Kolodgie, Hiroyuki Jinnouchi, Atsushi Sakamoto, Joohyung Park, Kazuyuki Yahagi, Kenichi Sakakura, Anne Cornelissen, Rika Kawakami, Masayuki Mori, Kenji Kawai, Falone Amoa, Liang Guo, Matthew Kutyna, Raquel Fernandez, Maria E. Romero, David Fowler, Aloke V. Finn, Renu Virmani
Journal: Journal of the American College of Cardiology (2021)
Multiple coronary arterioventricular fistulae.
Authors: A GRose
Journal: Circulation (1978)

A 62-year-old man who died suddenly was found at autopsy to have multiple coronary arteriosystemic fistulae involving all three major coronary arteries and both ventricles. This is the second such case reported and the first with biventricular involvement and autopsy findings. A congenital bicuspid valve was also present. Numerous small blood vessels opened onto the endocardial surface of both ventricles and there were microscopic foci of persistent embryonic spongy myocardium.
Ventricular/vascular coupling and regional arterial dynamics in the chronically hypertensive baboon: correlation with cardiovascular structural adaptation.
Authors: R DLatham, B JRubal, PSipkema, NWesterhof, RVirmani, MRobinowitz, R AWalsh
Journal: Circulation Research (1988)

Ventricular/vascular coupling dynamics and regional hemodynamics of five hypertensive baboons with concentric left ventricular (LV) hypertrophy (mean arterial pressure +/- SD, 148 +/- 16 mm Hg; LV mass/body weight ratio 3.42 +/- 0.8) were compared with five normotensive controls (mean arterial pressure 89 +/- 3 mm Hg; LV mass/body wt ratio 2.73 +/- 0.5) at different mean arterial pressures. Ventricular/vascular dynamics were assessed by aortic input impedance, pulsatile/total power ratio, effective arterial elastance and compliance from a three-element Windkessel lumped model of the circulation. Regional arterial dynamics were assessed by pulse-wave velocities and local reflection coefficients. Systemic arterial compliance was similarly decreased with elevated pressure in both groups but was significantly more reduced for the hypertensive group compared with control animals at control (0.49 +/- 0.16 vs. 0.96 +/- 0.09 ml/mm Hg; p less than 0.05) and acutely lowered arterial pressure (0.62 +/- 0.26 vs. 1....
Structural and electrophysiological changes in the epicardial border zone of canine myocardial infarcts during infarct healing.
Authors: P CUrsell, P IGardner, AAlbala, J JFenoglio, A LWit
Journal: Circulation Research (1985)

Structural and electrophysiological properties of the epicardial muscle which survives on the surface of transmural infarcts of the canine heart (epicardial border zone) were studied at different times after occlusion of the left anterior coronary artery (LAD). Isolated preparations were superfused in vitro, transmembrane potentials recorded, and impulse propagation mapped. In preparations from subacute infarcts (1 and 5 days), resting potential, action potential amplitude, upstroke velocity, and duration were all significantly reduced. Well-defined directional differences in propagation occurred. Propagation was more rapid in the direction perpendicular to the left anterior coronary artery than in the direction perpendicular to the base of the heart, because of the uniform anisotropic structure of the surviving muscle fibers which were arranged in tightly packed bundles oriented perpendicular to the left anterior coronary artery. The only ultrastructural abnormalities found in these muscle fibers was an ...
Telemedicine in Heart Failure—Ineffective or Just Ill Used?
Authors: Maulik D. Majmudar, Timothy Dy Aungst
Journal: JAMA Internal Medicine (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Effects of thrombolytic therapy administered 6 to 24 hours after myocardial infarction on the signal-averaged ECG. Results of a multicenter randomized trial. LATE Ancillary Study Investigators. Late Assessment of Thrombolytic Efficacy.
Authors: J SSteinberg, J SHochman, C DMorgan, PDorian, C DNaylor, PTheroux, E JTopol, P WArmstrong
Journal: Circulation (1994)

BACKGROUNDThrombolytic therapy reduces mortality after acute myocardial infarction, even when treatment is initiated relatively late after onset of symptoms. The mechanism underlying this survival benefit is incompletely understood.METHODS AND RESULTSIn a prospectively designed ancillary study of a randomized, placebo-controlled trial of late thrombolytic therapy (LATE), the signal-averaged (SA) ECG was recorded before hospital discharge in an effort to assess the effect of thrombolytic therapy on arrhythmia substrate. Three hundred ten patients were enrolled at 23 participating sites; 160 patients received placebo, and 150 patients received recombinant tissue-type plasminogen activator (rTPA) therapy 6 to 24 hours after onset of symptoms. Compared with placebo, rTPA tended to reduce the frequency of SAECG abnormality (filtered QRS duration > 120 milliseconds) by 37% (95% CI, -64%, +6%; P = .087) and the filtered QRS duration (105.7 +/- 13.8 versus 108.8 +/- 14.6 milliseconds, P = .05). In the prespecifie...
Induction of acidic fibroblast growth factor and full-length platelet-derived growth factor expression in human cardiac allografts. Analysis by PCR, in situ hybridization, and immunohistochemistry.
Authors: X MZhao, T KYeoh, W HFrist, D LPorterfield, G GMiller
Journal: Circulation (1994)

BACKGROUNDFurther understanding of cardiac allograft vasculopathy (CAV) is needed to improve long-term survival after cardiac transplantation. The diffuse hyperplasia of coronary intima characteristic of CAV suggests that growth factors may play a role in the development of CAV. Fibroblast growth factor (FGF) and platelet-derived growth factor (PDGF) are potent mitogens for smooth muscle cells (SMCs), and PDGF is an important cofactor in the pathogenesis of native coronary atherosclerosis.METHODS AND RESULTSReverse transcriptase/polymerase chain reaction (RT/PCR), in situ hybridization, and immunohistochemistry were used to determine whether transplantation results in increased cardiac expression of acidic (a) FGF, basic (b) FGF, and PDGF-A and -B chains. Sixty-eight myocardial biopsies from 36 heart transplant recipients and 7 normal hearts were analyzed by PCR. aFGF mRNA was present in 54 of 61 allograft biopsies and was not found in any normal heart. In situ hybridization and immunohistochemistry demon...
Lipoxygenase products induce neutrophil activation and increase endothelial permeability after thrombin-induced pulmonary microembolism.
Authors: M BPerlman, AJohnson, WJubiz, A BMalik
Journal: Circulation Research (1989)

We examined the mechanism of the neutrophil (PMN)-dependent increase in pulmonary vascular permeability to protein after thrombin-induced pulmonary microembolism. Humoral factors that activate PMNs after thrombin-induced pulmonary microembolism were characterized in pulmonary lymph obtained from unanesthetized sheep challenged with intravenous infusion of alpha-thrombin. Time-dependent increases in PMN migration, aggregation, and superoxide anion (O2-) generation were induced by the pulmonary lymph obtained within 20 minutes after thrombin infusion. The pulmonary lymph neutrophil activating factors present in ether extracts of lymph had retention times of leukotriene B4 (LTB4) and monohydroxyeicosatetraenoic acids (HETEs) by high-performance liquid chromatography. The postthrombin lymph samples containing the LTB4 and HETEs increased PMN O2- generation and endothelial monolayer permeability to 125I-albumin in the presence of PMNs layered on the endothelial monolayers. Control lymph samples replete with LT...
Use of aortic counterpulsation to improve sustained coronary artery patency during acute myocardial infarction. Results of a randomized trial. The Randomized IABP Study Group.
Authors: E MOhman, B SGeorge, C JWhite, M JKern, P AGurbel, R JFreedman, CLundergan, J RHartmann, J DTalley, M JFrey
Journal: Circulation (1994)

BACKGROUNDAortic counterpulsation has been observed to reduce the rate of reocclusion of the infarct-related artery after patency has been restored during acute myocardial infarction in observational studies. To evaluate the benefit-to-risk ratio of aortic counterpulsation during the early phase of myocardial infarction, a multicenter randomized clinical trial was performed.METHODS AND RESULTSPatients who had patency restored during acute cardiac catheterization within the first 24 hours of onset of myocardial infarction were randomly assigned to aortic counterpulsation for 48 hours versus standard care. Intravenous heparin was used similarly in both groups and was continued for a median (25th, 75th percentile) of 5 (2,7) days. A total of 182 patients were enrolled; 96 were assigned to aortic counterpulsation and 86 to standard care. Repeat cardiac catheterization was performed at a median of 5 (4,6) days after randomization in 89% of patients assigned to aortic counterpulsation and in 90% of control pati...
Long-term hemodynamic effects of prenalterol in patients with severe congestive heart failure.
Authors: HLambertz, JMeyer, RErbel
Journal: Circulation (1984)

In a controlled, randomized, double-blind study we investigated the long-term effects of the beta 1-adrenoceptor agonist prenalterol in 16 patients with severe congestive heart failure (NYHA class III or IV). Previous to and 1 week, 3 months, and 6 months after continuous oral intake of 40 to 120 mg prenalterol a day, catheterization of the right heart combined with an ergometer test was carried out; M mode and two dimensional echocardiograms as well as systolic time intervals were also recorded. With prenalterol the heart rate increased within 1 week from 81 +/- 7 to 90 +/- 7 beats/min (mean +/- SD) (p less than .05) and remained increased after 3 months (93 +/- 9 beats/min, p less than .01) and 6 months (91 +/- 6 beats/min, p less than .05). After 1 week the cardiac index rose from 2.7 +/- 0.7 to 3.3 +/- 0.7 l/min/m2 (p less than .01), and after 3 and 6 months it fell again to 3.0 +/- 0.9 l/min/m2 and 2.9 +/- 0.7 l/min/m2, respectively. In the ergometer test the improvement in performance was not signif...
Fertility Preservation in Women
Authors: Michaël Grynberg, Charlotte Sonigo, Pietro Santulli
Journal: New England Journal of Medicine (2018)

Fertility preservation is a fast growing discipline with the purpose of offering different techniques for women facing with pathologies or treatments threatening their fertility. Recent advances in fertility preservation techniques have led to a widespread of indications. Fertility preservation should now be considered not only for women having to receive gonadotoxic treatments for cancer but also in genetic or endocrine disorders, as well as benign ovarian diseases at risk of premature ovarian insufficiency. These situations could lead medical and ethical concerns and need for multidisciplinary management.