tbuckley/cabot-search huggingface dataset:
Effect of Adjuvant Metronomic Capecitabine on Disease-Free Survival Among Patients With Early-Stage Triple-Negative Breast Cancer
Authors: Feng Du, Peng Yuan
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LOCATION OF POTENTIAL PLAQUE DESTABILIZING FEATURES IN HIGH-RISK PLAQUES WITH ABNORMAL RFR: SPATIAL HETEROGENEITY AMONG ENDOTHELIAL SHEAR STRESS (ESS) AND SHEAR STRESS GRADIENTS (ESSG)
Authors: Diaa Hakim, Ahmet Coskun, Charles Maynard, Zongyue Pu, Deborah Rupert, Barbora Zvarova, Nicholas V Cefalo, Michelle A Cormier, Gerasimos Siasos, Dimitris Fotiadis, Kostas Stefanou, Michail Papafaklis, Lampros Michalis, Peter Stone, Kevin Croce
Journal: Journal of the American College of Cardiology (2021)
Biden administration proposes making opioid addiction treatment more easily available
Authors: Janice Hopkins Tanne
Journal: BMJ (2021)

The US government has proposed rule changes that would make buprenorphine, a treatment for opioid use disorder, more easily available.1

The Department of Health and Human Services’ proposed new rules go further than changes suggested by the Trump administration in its last days.2 If approved, they will allow nearly all doctors and many other providers to prescribe the anti-addiction drug.

The US has a drug addiction and overdose death problem, owing especially to the …
PRE-PCI RESIDUAL QUANTITATIVE FLOW RATIO FOR ESTIMATING POST-PCI FFR
Authors: Pepijn Van Diemen, Stefan Schumacher, Michiel Bom, Roel Driessen, Henk Everaars, Ruben de Winter, Ruurt Jukema, Albert Van Rossum, Maksymilian Opolski, Ibrahim Danad, Paul Knaapen
Journal: Journal of the American College of Cardiology (2021)
Apilimod alters TGFβ signaling pathway and prevents cardiac fibrotic remodeling
Authors: Mathieu Cinato, Laurie Guitou, Amira Saidi, Andrei Timotin, Erwan Sperazza, Thibaut Duparc, Sergey N. Zolov, Sai Srinivas Panapakkam Giridharan, Lois S. Weisman, Laurent O. Martinez, Jerome Roncalli, Oksana Kunduzova, Helene Tronchere, Frederic Boal
Journal: Theranostics (2021)

TGFβ signaling pathway controls tissue fibrotic remodeling, a hallmark in many diseases leading to organ injury and failure. In this study, we address the role of Apilimod, a pharmacological inhibitor of the lipid kinase PIKfyve, in the regulation of cardiac pathological fibrotic remodeling and TGFβ signaling pathway.
ESTABLISHED VS. DE NOVO PRESENTATIONS OF ACUTE DECOMPENSATED HEART FAILURE-RELATED CARDIOGENIC SHOCK (ADHF-CS) IN CARDIAC INTENSIVE CARE UNITS (CICU) DATA FROM THE CRITICAL CARE CARDIOLOGY TRIALS NETWORK (CCCTN) REGISTRY
Authors: Ankeet Bhatt, David Berg, Sean Van Diepen, Jason Katz, David Morrow
Journal: Journal of the American College of Cardiology (2021)
Trends and impact on cold ischemia time and clinical outcomes using virtual crossmatch for deceased donor kidney transplantation in the United States
Authors: Chethan M Puttarajappa, Dana Jorgensen, Jonathan G Yabes, Kwonho Jeong, Adriana Zeevi, John Lunz, Amit D Tevar, Michele Molinari, Sumit Mohan, Sundaram Hariharan
Journal: Kidney International (2021)
HIGHER RED CELL DISTRIBUTION WIDTH IS ASSOCIATED WITH THE PRESENCE OF CALCIFICATION IN CORONARY PLAQUE
Authors: Ayami Kato, Yoshiyasu Minami, Takako Nagata, Kiyoshi Asakura, Masahiro Katamine, Aritomo Katsura, Daisuke Kinoshita, Takuya Hashimoto, Junya Ako
Journal: Journal of the American College of Cardiology (2021)
SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models
Authors: Axel Hyrenius-Wittsten, Yang Su, Minhee Park, Julie M. Garcia, Josef Alavi, Nathaniel Perry, Garrett Montgomery, Bin Liu, Kole T. Roybal
Journal: Science Translational Medicine (2021)

The first clinically approved engineered chimeric antigen receptor (CAR) T cell therapies are remarkably effective in a subset of hematological malignancies with few therapeutic options. Although these clinical successes have been exciting, CAR T cells have hit roadblocks in solid tumors that include the lack of highly tumor-specific antigens to target, opening up the possibility of life-threatening "on-target/off-tumor" toxicities, and problems with T cell entry into solid tumor and persistent activity in suppressive tumor microenvironments. Here, we improve the specificity and persistent antitumor activity of therapeutic T cells with synthetic Notch (synNotch) CAR circuits. We identify alkaline phosphatase placental-like 2 (ALPPL2) as a tumor-specific antigen expressed in a spectrum of solid tumors, including mesothelioma and ovarian cancer. ALPPL2 can act as a sole target for CAR therapy or be combined with tumor-associated antigens such as melanoma cell adhesion molecule (MCAM), mesothelin, or human epidermal growth factor receptor 2 (HER2) in synNotch CAR combinatorial antigen circuits. SynNotch CAR T cells display superior control of tumor burden when compared to T cells constitutively expressing a CAR targeting the same antigens in mouse models of human mesothelioma and ovarian cancer. This was achieved by preventing CAR-mediated tonic signaling through synNotch-controlled expression, allowing T cells to maintain a long-lived memory and non-exhausted phenotype. Collectively, we establish ALPPL2 as a clinically viable cell therapy target for multiple solid tumors and demonstrate the multifaceted therapeutic benefits of synNotch CAR T cells.
AN ABNORMAL FLOW A RARE CAUSE OF HEART FAILURE IN A PATIENT WITH PRIOR AORTIC VALVE REPLACEMENT
Authors: Gunjan S. Joshi, Thanh Hoang, William Sanchez-Garcia, Amudhan Jyothidasan, Haitham Mazek, Divyang Patel, Amol Bahekar, Thor Klang, Manoj Bhandari
Journal: Journal of the American College of Cardiology (2021)
THE EFFICACY OF POSTERIOR WALL ISOLATION IN ATRIAL FIBRILLATION ABLATION: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
Authors: Chanavuth Kanitsoraphan, Pattara Rattanawong, Jakrin Kewcharoen, Chol Techorueangwiwat, Raktham Mekritthikrai, Narut Prasitlumkum, Hicham El Masry
Journal: Journal of the American College of Cardiology (2021)
THE EFFICACY AND SAFETY OF ALIROCUMAB IN CHILDREN AND ADOLESCENTS WITH HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA (HOFH): PHASE 3, MULTINATIONAL OPEN-LABEL STUDY
Authors: Eric Bruckert, Sonia Caprio, Albert Wiegman, Min-Ji Charng, A Zarate-Morales Cezar, Ifode Ajari, Marie Baccara-Dinet, Garen Manvelian, Anne Ourliac, Michel Scemama, R Daniels Stephen
Journal: Journal of the American College of Cardiology (2021)
Suppression, resolve, and habit in everyday financial behaviour
Authors: Stephen E. G. Lea
Journal: Behavioral and Brain Sciences (2021)

Abstract Everyday financial behaviour involves inter-temporal choices, between saving, spending, and debt. Consumers do not always take these decisions to their best advantage. Ainslie's analysis of the means to willpower as suppression, resolve, and habit is potentially applicable to understanding and improving the decisions that consumers make. Some relevant research on these topics exists, and it is briefly reviewed here.
Air Pollution and COVID-19 Mortality in New York City
Authors: Honghyok Kim, Michelle L. Bell
Journal: American Journal of Respiratory and Critical Care Medicine (2021)

The health impact of coronavirus disease (COVID-19) appears disproportionate across populations.Biological mechanisms of prognosis of suggest that long-term exposure to ambient air pollution may contribute to health disparities.Mortality impacts including those from pneumonia and cardiovascular events due to longterm exposure to air pollution are well established (2-5).Early studies covering multiple neighborhoods (e.g., U.S. counties) suggest that longterm exposure to particulate matter <2.5 mm in aerodynamic diameter (PM 2.5 ) and ozone (O 3 ) may be linked with higher risk of COVID-19 mortality (6-8).However, many questions remain regarding linkages between COVID-19 and air pollution.Particularly, pollution levels vary by community, and evidence based on high spatially resolved data such as for neighborhoods is lacking (9).Potential determinants of transmission and prognosis of COVID-19 (e.g., urbanicity, socioeconomic conditions, race/ethnicity, health behaviors, access to health care) are disproportionately distributed across neighborhoods.These factors may have impacted findings of early studies because of possible residual confounding.We conducted cross-sectional analysis to investigate association between long-term exposure to PM 2.5 and O 3 and COVID-19 confirmed mortality in 177 neighborhoods (i.e., five-digit modified ZIP code tabulation areas [MZCTAs]) in New York City, New York.COVID-19 data from February 29, 2020, to January 5, 2021, were obtained from the New York City (NYC) Health Department's COVID-19 Data Website.The date of the first confirmed COVID-19 case and death is February 29 and March 11, 2020, respectively.Annual average PM 2.5 levels from December
WHEN ONLY THE BEST WILL DO: 12-LEAD ECG DIFFERENTIATES ATRIAL TACHYCARDIA FROM SINUS TACHYCARDIA DURING TILT TABLE TESTING FOR PRESUMED POSTURAL TACHYCARDIA SYNDROME
Authors: Gauranga Mahalwar, Jeffery Courson, Mandeep Bhargava, Kenneth Mayuga
Journal: Journal of the American College of Cardiology (2021)
USE OF EXPORT VS. BALLOON IN PRIMARY PERCUTANEOUS CORONARY INTERVENTION, IN-HOSPITAL OUTCOMES AND OPTIMAL EXPORT TIME
Authors: Dileep Kumar, Tahir Saghir, Jawaid Akbar Sial, Rajesh Kumar, Musa Karim, Zil-e- Huma, Nadeem Qamar
Journal: Journal of the American College of Cardiology (2021)
Bfr (bendamustine, fludarabine, rituximab) Nonmyeloablative Allogeneic Conditioning for Lymphoid Malignancies: 8-Year Results
Authors: Issa F. Khouri, Elias J. Jabbour, Celina Ledesma, Martin Korbling, Amin M. Alousi, Paolo Anderlini, Betul Oran, Stefan O. Ciurea, Luis E. Fayad, Roland L. Bassett, Alison M. Gulbis
Journal: Blood (2017)
Efficacy and safety of ruxolitinib cream for the treatment of atopic dermatitis: Results from 2 phase 3, randomized, double-blind studies
Authors: Kim Papp, Jacek C. Szepietowski, Leon Kircik, Darryl Toth, Lawrence F. Eichenfield, Donald Y.M. Leung, Seth B. Forman, May E. Venturanza, Kang Sun, Michael E. Kuligowski, Eric L. Simpson
Journal: Journal of the American Academy of Dermatology (2021)

Ruxolitinib (RUX) cream demonstrated potent anti-inflammatory and antipruritic efficacy in a phase 2 study in adults with atopic dermatitis (AD).To evaluate 8-week efficacy and safety in 2 phase 3 studies of RUX cream in patients with AD.Topical Ruxolitinib Evaluation in Atopic Dermatitis Study 1 (NCT03745638) and Study 2 (NCT03745651) enrolled patients aged ≥12 years with AD for ≥2 years, an Investigator's Global Assessment score of 2/3, and 3%-20% affected body surface area. Patients were randomized 2:2:1 to twice-daily 0.75% RUX cream, 1.5% RUX cream, or vehicle cream for 8 continuous weeks. The primary endpoint was Investigator's Global Assessment treatment success at week 8 (Investigator's Global Assessment score of 0/1 and ≥2-grade improvement from baseline).In the Topical Ruxolitinib Evaluation in Atopic Dermatitis Study 1 and 2, 631 and 618 patients were randomized (631/577 analyzed for efficacy). Significantly more patients achieved Investigator's Global Assessment treatment success with 0.75% RUX cream (50.0%/39.0%) and 1.5% RUX cream (53.8%/51.3%) versus vehicle (15.1%/7.6%; P < .0001) at week 8. Significant itch reductions versus vehicle were reported within 12 hours of first application of 1.5% RUX (P < .05). Application site reactions were infrequent (<1%) and lower with RUX versus vehicle; none were clinically significant.Longer-term safety data are not yet available.RUX cream showed anti-inflammatory and prompt antipruritic effects with superior efficacy versus vehicle and was well tolerated.
Helen Salisbury: Routes to recovery
Authors: Helen Salisbury
Journal: BMJ (2021)

One of the hardest parts of being ill is not knowing when, or even if, you’ll be well again. As doctors we’re often asked about this, but only sometimes can we provide a definitive answer. There are published estimates for some conditions, although a quick look online shows that these vary widely, even for relatively well defined problems such as broken bones. Patients often have over-optimistic ideas (occasionally acquired in the emergency department) about how quickly they’ll be back to normal, and they then need reassurance that ongoing discomfort isn’t a sign that something’s gone …
Preclinical and Clinical Characteristics of the Trichuricidal Drug Oxantel Pamoate and Clinical Development Plans: A Review
Authors: Marta S. Palmeirim, Sabine Specht, Ivan Scandale, Irene Gander-Meisterernst, Monika Chabicovsky, Jennifer Keiser
Journal: Drugs (2021)

Soil-transmitted helminths (Ascaris lumbricoides, hookworm and Trichuris trichiura) infect about one-fifth of the world's population. The currently available drugs are all highly efficacious against A. lumbricoides. However, they are only moderately efficacious against hookworm and poorly efficacious against T. trichiura. Oxantel, a tetrahydropyrimidine derivative discovered in the 1970s, has recently been brought back to our attention given its high efficacy against T. trichiura infections (estimated 76% cure rate and 85% egg reduction rate at a 20 mg/kg dose). This review summarizes the current knowledge on oxantel pamoate and its use against T. trichiura infections in humans. Oxantel pamoate acts locally in the human gastrointestinal tract and binds to the parasite's nicotinic acetylcholine receptor (nAChR), leading to a spastic paralysis of the worm and subsequent expulsion. The drug is metabolically stable, shows low permeability and low systemic bioavailability after oral use. Oxantel pamoate was found to be safe in humans, with only a few mild adverse events reported. Several clinical trials have investigated the efficacy of this drug against T. trichiura and suggest that oxantel pamoate is more efficacious against T. trichiura than the currently recommended drugs, which makes it a strong asset to the depleted drug armamentarium and could help delay or even prevent the development of resistance to existing drugs. We highlight existing data to support the use of oxantel pamoate against T. trichiura infections.
Bioactive skin-mimicking hydrogel band-aids for diabetic wound healing and infectious skin incision treatment
Authors: Yuxuan Yang, Xiaodan Zhao, Jing Yu, Xingxing Chen, Ruyue Wang, Mengyuan Zhang, Qiang Zhang, Yanfeng Zhang, Shuang Wang, Yilong Cheng
Journal: Bioactive Materials (2021)

The treatment of diabetic chronic wounds remains a global challenge due to the up-regulated inflammation response, oxidant stress, and persistent infection during healing process. Developing wound dressing materials with ideal biocompatibility, adequate mechanical strength, considerable under-water adhesion, sufficient anti-inflammation, antioxidant, and antibacterial properties is on-demand for clinical applications. In this study, we developed a bioactive skin-mimicking hydrogel band-aid through the combination of tannic acid (TA) and imidazolidinyl urea reinforced polyurethane (PMI) (TAP hydrogel) and explored its potentials in various medical applications, including hemostasis, normal skin incision, full-thickness skin wounds, and bacterial-infection skin incision on diabetic mice. TA was loaded into PMI hydrogel network to enhance the mechanical properties of TAP hydrogels through multiple non-covalent interactions (break strength: 0.28-0.64 MPa; elongation at break: 650-930%), which could resist the local stress and maintain the structural integrity of wound dressings during applications. Moreover, owing to the promising moisture-resistant adhesiveness and organ hemostasis, outstanding anti-inflammation, antibacterial, and antioxidant properties, TAP hydrogels could efficiently promote the recovery of skin incision and defects on diabetic mice. To further simulate the practical situation and explore the potential in clinical application, we also verified the treatment efficiency of TAP hydrogel in S. aureus-infected skin incision model on diabetic mice.
In-vitro tumor microenvironment models containing physical and biological barriers for modelling multidrug resistance mechanisms and multidrug delivery strategies
Authors: Mehdi Rahmanian, Amir Seyfoori, Mohsen Ghasemi, Milad Shamsi, Ahmad Rezaei Kolahchi, Hassan Pezeshgi Modarres, Amir Sanati-Nezhad, Keivan Majidzadeh-A
Journal: Journal of Controlled Release (2021)
RADIO-FREQUENCY CATHETER-BASED PULMONARY DENERVATION FOR SEVERE PULMONARY HYPERTENSION: INITIAL FEASIBILITY
Authors: Swati Rao, Andrew Beaser, Zaid Aziz, Gaurav Upadhyay, Hemal Nayak, Remzi Bag, Roderick Tung
Journal: Journal of the American College of Cardiology (2021)
Non-viral gene delivery of the oncotoxic protein NS1 for treatment of hepatocellular carcinoma
Authors: Dominik Witzigmann, Philip Grossen, Cristina Quintavalle, Manuela Lanzafame, Susanne H. Schenk, Xue-Ting Tran, Bernhard Englinger, Patrick Hauswirth, David Grünig, Sushilla van Schoonhoven, Stephan Krähenbühl, Luigi M. Terracciano, Walter Berger, Salvatore Piscuoglio, Luca Quagliata, Jean Rommelaere, Jürg P.F. Nüesch, Jörg Huwyler
Journal: Journal of Controlled Release (2021)

Hepatocellular carcinoma (HCC) is related to increasing incidence rates and poor clinical outcomes due to lack of efficient treatment options and emerging resistance mechanisms. The aim of the present study is to exploit a non-viral gene therapy enabling the expression of the parvovirus-derived oncotoxic protein NS1 in HCC. This anticancer protein interacts with different cellular kinases mediating a multimodal host-cell death. Lipoplexes (LPX) designed to deliver a DNA expression plasmid encoding NS1 are characterized using a comprehensive set of in vitro assays. The mechanisms of cell death induction are assessed and phosphoinositide-dependent kinase 1 (PDK1) is identified as a potential predictive biomarker for a NS1-LPX-based gene therapy. In an HCC xenograft mouse model, NS1-LPX therapeutic approach results in a significant reduction in tumor growth and extended survival. Data provide convincing evidence for future studies using a targeted NS1 gene therapy for PDK1 overexpressing HCC.
Deep Learning With Radiogenomics Towards Personalized Management of Gliomas
Authors: Sushmita Mitra
Journal: IEEE Reviews in Biomedical Engineering (2021)

A state-of-the-art interdisciplinary survey on multi-modal radiogenomic approaches is presented involving applications to the diagnosis and personalized management of gliomas a common kind of brain tumors through noninvasive imaging integrated with genomic information. It encompasses mining tumor radioimages employing deep learning for the automated extraction of relevant features from the segmented volume of interest (VOI). Gene expression values from surgically extracted tumor tissues are often simultaneously analyzed to determine patient specific features. Association between genomic and radiomic features are also explored in some cases to determine the imaging surrogates. Deep learning and transfer learning are typically exploited for efficient knowledge discovery and decision-making. Some studies on survival prediction ensemble learning and interactive learning are also included. The literature mainly focuses on magnetic resonance imaging (MRI) data of the brain for learning and validation and generally involves the NIH TCIA and TCGA repositories as well as the BraTS Challenge databases.
RACIAL DISPARITIES IN GUIDELINE DIRECTED STATIN IMPLEMENTATION AND CARDIOVASCULAR OUTCOMES: INSIGHTS FROM A REAL WORLD PRIMARY PREVENTION COHORT
Authors: Anum Saeed, Jianhui Zhu, Floyd Thoma, Emily Guhl, Oscar Marroquin, Aliza Hussain, Nosheen Reza, Khurram Nasir, Salim Virani, Conrad Smith, Suresh Mulukutla
Journal: Journal of the American College of Cardiology (2021)
National Marrow Donor Program–Sponsored Multicenter, Phase II Trial of HLA-Mismatched Unrelated Donor Bone Marrow Transplantation Using Post-Transplant Cyclophosphamide
Authors: Bronwen E. Shaw, Antonio Martin Jimenez-Jimenez, Linda J. Burns, Brent R. Logan, Farhad Khimani, Brian C. Shaffer, Nirav N. Shah, Alisha Mussetter, Xiao-Ying Tang, John M. McCarty, Asif Alavi, Nosha Farhadfar, Katarzyna Jamieson, Nancy M. Hardy, Hannah Choe, Richard F. Ambinder, Claudio Anasetti, Miguel-Angel Perales, Stephen R. Spellman, Alan Howard, Krishna V. Komanduri, Leo Luznik, Maxim Norkin, Joseph A. Pidala, Voravit Ratanatharathorn, Dennis L. Confer, Steven M. Devine, Mary M. Horowitz, Javier Bolaños-Meade
Journal: Journal of Clinical Oncology (2021)

Hematopoietic cell transplantation (HCT) is curative for hematologic disorders, but outcomes are historically inferior when using HLA-mismatched donors. Despite unrelated donor registries listing > 38 million volunteers, 25%-80% of US patients lack an HLA-matched unrelated donor, with significant disparity across ethnic groups. We hypothesized that HCT with a mismatched unrelated donor (MMUD) using post-transplant cyclophosphamide (PTCy), a novel strategy successful in overcoming genetic disparity using mismatched related donors, would be feasible and increase access to HCT.