tbuckley/cabot-search huggingface dataset:
Association of Leukocyte Adhesion and Rolling in Skin With Patient Outcomes After Hematopoietic Cell Transplantation Using Noninvasive Reflectance Confocal Videomicroscopy
Authors: Inga Saknite, James R. Patrinely, Zijun Zhao, Heidi Chen, Alicia Beeghly-Fadiel, Tae Kon Kim, Madan Jagasia, Michael Byrne, Eric R. Tkaczyk
Journal: JAMA Dermatology (2022)

Hematopoietic cell transplantation (HCT) is a potential cure for hematologic cancer but is associated with a risk of relapse and death. Dynamic biomarkers to predict relapse and inform treatment decisions after HCT are a major unmet clinical need.To identify a quantitative characteristic of leukocyte-endothelial interactions after HCT and test its associations with patient outcomes.In this prospective single-center cohort study from June 2017 to January 2020, patients of any age, sex, race, and ethnicity who had HCT for hematologic cancer were referred by health care professionals as either suspected of having symptoms or not having symptoms of acute graft-vs-host disease between 25 and 161 days after HCT. Patients underwent noninvasive skin videomicroscopy. Videos of dermal microvascular flow were recorded with a reflectance confocal microscope. Two blinded observers (J.R.P. and Z.Z.) counted leukocytes adherent to and rolling along the vessel wall per hour (A&R). Of 57 enrolled patients, 1 relapsed before imaging and was excluded, resulting in 56 patients included in analyses.Relapse of cancer, relapse-free survival, and overall survival.Among the 56 patients (median age, 59 years; 38 [68%] male) who underwent imaging a median of 40 days after HCT, 21 had high A&R and 35 had low A&R. After correcting for the revised Disease Risk Index, patients with high A&R had higher rates of relapse (hazard ratio [HR], 4.24; 95% CI, 1.32-13.58; P = .02), reduced relapse-free survival (HR, 3.29; 95% CI, 1.26-8.55; P = .02), and reduced overall survival (HR, 3.06, 95% CI, 1.02-9.19; P = .05). These associations were preserved after correcting for possible confounders, steroid treatment, and acute graft-vs-host disease status. In the prognostic adequacy calculation by using Cox models, the new imaging biomarker (A&R) accounted for 82% to 95% of the prognostic information to predict each outcome. By contrast, the best existing clinical predictor routinely available, the revised Disease Risk Index, accounted for 10% to 28% of the prognostic information in the same model.In this cohort study, leukocyte-endothelial interactions, visualized directly in skin after HCT, were associated with the patient outcomes of relapse, relapse-free survival, and overall survival. Assessing this dynamic marker could help patients at high risk for relapse who may benefit from interventions, such as early withdrawal of immunosuppression.
HIGHER MODIFIED BODY MASS INDEX IS ASSOCIATED WITH DECREASED MORTALITY AND BLEEDING AFTER TREATMENT FOR SEVERE PE
Authors: Danial Saleem, Mahesh Madhavan, Caroline Nigoghossian, Elissa Driggin, Shayan Nouri, John Burton, Heidi Lumish, Michael Lavelle, Jianhua Li, Erika Berman-Rosenzweig, Koji Takeda, Ajay J. Kirtane, Justin Fried, Daniel Brodie, Cara Agerstrand, Andrew Jeffrey Einstein, Mathew S. Maurer, Sahil A. Parikh, Sanjum S. Sethi, Matthew Finn
Journal: Journal of the American College of Cardiology (2022)
Interleukin-10 contributes to reservoir establishment and persistence in SIV-infected macaques treated with antiretroviral therapy
Authors: Justin Harper, Susan P. Ribeiro, Chi Ngai Chan, Malika Aid, Claire Deleage, Luca Micci, Maria Pino, Barbara Cervasi, Gopalan Raghunathan, Eric Rimmer, Gulesi Ayanoglu, Guoxin Wu, Neeta Shenvi, Richard J.O. Barnard, Gregory Q. Del Prete, Kathleen Busman-Sahay, Guido Silvestri, Deanna A. Kulpa, Steven E. Bosinger, Kirk A. Easley, Bonnie J. Howell, Dan Gorman, Daria J. Hazuda, Jacob D. Estes, Rafick-Pierre Sekaly, Mirko Paiardini
Journal: Journal of Clinical Investigation (2022)

Interleukin-10 (IL-10) is an immunosuppressive cytokine that signals through STAT3 to regulate T follicular helper (Tfh) cell differentiation and germinal center formation. In SIV-infected macaques, levels of IL-10 in plasma and lymph nodes (LNs) were induced by infection and not normalized with antiretroviral therapy (ART). During chronic infection, plasma IL-10 and transcriptomic signatures of IL-10 signaling were correlated with the cell-associated SIV-DNA content within LN CD4+ memory subsets, including Tfh cells, and predicted the frequency of CD4+ Tfh cells and their cell-associated SIV-DNA content during ART, respectively. In ART-treated rhesus macaques, cells harboring SIV-DNA by DNAscope were preferentially found in the LN B cell follicle in proximity to IL-10. Finally, we demonstrated that the in vivo neutralization of soluble IL-10 in ART-treated, SIV-infected macaques reduced B cell follicle maintenance and, by extension, LN memory CD4+ T cells, including Tfh cells and those expressing PD-1 and CTLA-4. Thus, these data support a role for IL-10 in maintaining a pool of target cells in lymphoid tissue that serve as a niche for viral persistence. Targeting IL-10 signaling to impair CD4+ T cell survival and improve antiviral immune responses may represent a novel approach to limit viral persistence in ART-suppressed people living with HIV.
PROGNOSTIC OUTCOMES OF PATIENTS WITH CONCOMITANT ACUTE CORONARY SYNDROME AND AORTIC STENOSIS
Authors: Yeung Jek Ho, Nicholas WS WS, Aaron Mai, Cheng Han Ng, Gwyneth Kong, Yinghao Lim, Ivandito Kuntjuro, William KF Kong, Koo Hui Chan, Yan Yee, Mark Chan, Adrian Low, Chi-Hang Lee, Tiong Cheng Yeo, James Wei Luen Yip, Huay-Cheem Tan, Kian Keong Poh, Poay Huan Loh
Journal: Journal of the American College of Cardiology (2022)
IMPACT OF DIFFERENTIAL LEFT VENTRICULAR GEOMETRY AND TISSUE SUBSTRATE REMODELING ON LEFT VENTRICULAR THROMBUS LOCATION: MULTIPARAMETRIC ASSESSMENT VIA CARDIAC MAGNETIC RESONANCE
Authors: Justin Johannesen, Ruth Kagan, Pablo Villar Calle, Katherine Tak, Rachel Meier, Tania Ruiz, Alice Saffioti, Angel Chan, Jiwon Kim, Jonathan W. Weinsaft
Journal: Journal of the American College of Cardiology (2022)
Point-of-Care Ultrasonography: Clearly More Than a Pretty Picture
Authors: Timothy J. Wilt, Carolyn J. Crandall, Amir Qaseem
Journal: JAMA Internal Medicine (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Assessing the Causal Role of Sleep Traits on Glycated Hemoglobin: A Mendelian Randomization Study
Authors: Junxi Liu, Rebecca C. Richmond, Jack Bowden, Ciarrah Barry, Hassan S. Dashti, Iyas Daghlas, Jacqueline M. Lane, Samuel E. Jones, Andrew R. Wood, Timothy M. Frayling, Alison K. Wright, Matthew J. Carr, Simon G. Anderson, Richard A. Emsley, David W. Ray, Michael N. Weedon, Richa Saxena, Deborah A. Lawlor, Martin K. Rutter
Journal: Diabetes Care (2022)

OBJECTIVE To examine the effects of sleep traits on glycated hemoglobin (HbA1c). RESEARCH DESIGN AND METHODS This study triangulated evidence across multivariable regression (MVR) and one- (1SMR) and two-sample Mendelian randomization (2SMR) including sensitivity analyses on the effects of five self-reported sleep traits (i.e., insomnia symptoms [difficulty initiating or maintaining sleep], sleep duration, daytime sleepiness, napping, and chronotype) on HbA1c (in SD units) in adults of European ancestry from the UK Biobank (for MVR and 1SMR analyses) (n = 336,999; mean [SD] age 57 [8] years; 54% female) and in the genome-wide association studies from the Meta-Analyses of Glucose and Insulin-Related Traits Consortium (MAGIC) (for 2SMR analysis) (n = 46,368; 53 [11] years; 52% female). RESULTS Across MVR, 1SMR, 2SMR, and their sensitivity analyses, we found a higher frequency of insomnia symptoms (usually vs. sometimes or rarely/never) was associated with higher HbA1c (MVR 0.05 SD units [95% CI 0.04–0.06]; 1SMR 0.52 [0.42–0.63]; 2SMR 0.24 [0.11–0.36]). Associations remained, but point estimates were somewhat attenuated after excluding participants with diabetes. For other sleep traits, there was less consistency across methods, with some but not all providing evidence of an effect. CONCLUSIONS Our results suggest that frequent insomnia symptoms cause higher HbA1c levels and, by implication, that insomnia has a causal role in type 2 diabetes. These findings could have important implications for developing and evaluating strategies that improve sleep habits to reduce hyperglycemia and prevent diabetes.
Smartphone applications for informal caregivers of chronically ill patients: a scoping review
Authors: Milena Guessi Margarido, Amika Shah, Emily Seto
Journal: npj Digital Medicine (2022)

Abstract Mobile-health applications can be used to deliver timely and personalized health information to family and friends of chronically ill adults living in the community. This scoping review aims to investigate the nature and extent of native smartphone applications for informal caregivers. Six databases were searched for articles on applications across ten chronic conditions, namely heart disease, stroke, cancer, chronic obstructive respiratory disease, asthma, diabetes, Alzheimer’s disease or other dementia, rheumatoid arthritis, hypertension, and mood or anxiety disorders. In total, 36 articles were included, encompassing 26 applications. Of these, smartphone applications were designed for use only by caregivers ( n = 15), with a few applications also intended to be used with patients ( n = 5), healthcare providers ( n = 4), or all three roles ( n = 2). Most applications targeted a single chronic condition ( n = 25), with Alzheimer’s and other dementia being the most common ( n = 18). Only one application was designed for management of multiple chronic conditions. Long-term evaluation methods are needed to continually assess the impact of applications on a range of process and health outcomes, such as usability, caregiver burden, and quality of life. Additional directions to advance native smartphone applications for caregivers are discussed, including personalization and expansion of eligibility criteria.
Reconstruction of a large-scale outbreak of SARS-CoV-2 infection in Iceland informs vaccination strategies
Authors: Kristjan E. Hjorleifsson, Solvi Rognvaldsson, Hakon Jonsson, Arna B. Agustsdottir, Margret Andresdottir, Kolbrun Birgisdottir, Ogmundur Eiriksson, Elias S. Eythorsson, Run Fridriksdottir, Gudmundur Georgsson, Kjartan R. Gudmundsson, Arnaldur Gylfason, Gudbjorg Haraldsdottir, Brynjar O. Jensson, Adalbjorg Jonasdotti, Aslaug Jonasdottir, Kamilla S. Josefsdottir, Nina Kristinsdottir, Borghildur Kristjansdottir, Thordur Kristjansson, Droplaug N. Magnusdottir, Runolfur Palsson, Louise le Roux, Gudrun M. Sigurbergsdottir, Asgeir Sigurdsson, Martin I. Sigurdsson, Gardar Sveinbjornsson, Emil Aron Thorarensen, Bjarni Thorbjornsson, Marianna Thordardottir, Agnar Helgason, Hilma Holm, Ingileif Jonsdottir, Frosti Jonsson, Olafur T. Magnusson, Gisli Masson, Gudmundur L. Norddahl, Jona Saemundsdottir, Patrick Sulem, Unnur Thorsteinsdottir, Daniel F. Gudbjartsson, Pall Melsted, Kari Stefansson
Journal: Clinical Microbiology and Infection (2022)
A Solitary Spinal Cord Metastasis From Lung Cancer Displayed on 18F-FDG PET/CT
Authors: Xiaoyue Tan, Li He, Jingyun Ren, Baozhen Zeng, Lei Jiang
Journal: Clinical Nuclear Medicine (2022)

Chest CT images were acquired in a 79-year-old man to evaluate a right lung mass revealed by chest radiography. The image findings suggested possible pulmonary malignancy. FDG PET/CT was performed for staging, which displayed not only a hypermetabolic mass in the upper lobe of right lung but also increased FDG uptake of the spinal cord at T11 to T12 level. A lesion corresponding to the hypermetabolic region of the spinal cord was revealed by MRI. The intramedullary spinal cord metastasis from lung squamous cell carcinoma was confirmed through the pathological examination after the spinal cord lesion was resected.
Making the law work for HIV responses
Authors: Mandeep Dhaliwal
Journal: BMJ (2022)

It's been more than four decades since the beginning of the AIDS pandemic, and its end ought to be within reach, in part thanks to remarkable advances in science such as a new, injectable form of pre-exposure prophylaxis (PrEP).However, inequalities continue to prolong and even worsen the pandemic.We have a unique opportunity with the "10-10-10 targets" outlined in the "2021 Political Declaration on HIV and AIDS: Ending Inequalities and Getting on Track to Ends AIDS by 2030": less than 10% of people living with HIV (PLHIV) and key populations experience stigma and discrimination; less than 10% of PLHIV, women and girls and key populations experience gender-based inequalities and gender-based violence; and less than 10% of countries have punitive laws and policies. 14
THE EFFECT OF OMECAMTIV MECARBIL IN HOSPITALIZED PATIENTS AS COMPARED WITH OUTPATIENTS: A PRESPECIFIED ANALYSIS OF GALACTIC-HF
Authors: Kieran F. Docherty, Brian Claggett, Rafael Diaz, G. Michael Felker, Marco Metra, Scott D. Solomon, Punag Divanji, Stephen B. Heitner, Stuart Kupfer, Fady I. Malik, John J.V. McMurray, John R. Teerlink
Journal: Journal of the American College of Cardiology (2022)
ANATOMIC VARIATIONS OF BELOW-THE-KNEE ARTERIES IN PATIENTS UNDERGOING ENDOVASCULAR REVASCULARIZATION: INSIGHTS FROM THE XLPAD REGISTRY
Authors: Michael Vu, Glaiza-Mae Sande-Docor, Yu-Lun Liu, Shirling Tsai, Mitul P. Patel, Peter Philip Monteleone, Mohamad Alaiti, Christopher Metzger, Emmanouil S. Brilakis, Mehdi H. Shishehbor, Subhash Banerjee
Journal: Journal of the American College of Cardiology (2022)
Abstract P1-24-05: Breast conserving surgery for non-metastatic inflammatory breast cancer: A National Cancer Database (NCDB) study
Authors: Fernando A. Angarita, Stephen B. Edge, Kristopher Attwood, Kazuaki Takabe, Jessica Young
Journal: Cancer Research (2022)

Abstract Background: Single center studies have suggested breast conserving surgery (BCS) as treatment for inflammatory breast cancer (IBC). Given its infrequency, a multi-hospital database study is useful. This study reports the characteristics, outcomes, and prognostic factors of women with non-metastatic IBC who underwent BCS. Methods: The National Cancer Database (NCDB) was queried for women ≥18 years old with cT4dN0-3M0. Outcomes were compared between treatment groups. A Cox proportional hazards model assessed the relationship of variables and the overall survival (OS). Results: A total of 12,223 women were treated as follows: no surgery (12.8%), BCS (3.3%), and mastectomy (83.9%). BCS was significantly more common in academic/research institutions, South and North-East hospitals, no special type histology, triple negative breast cancer, single quadrant tumors, and node-negative tumors. Most patients who underwent BCS received chemotherapy (86.2%) and radiation therapy (61.9%), while hormonal therapy was infrequent (37.1%). Mortality was higher with BCS than mastectomy at 30 (1.3% versus 0.3%, p&amp;lt;0.001) and 90 (6.8% versus 1.5%, p&amp;lt;0.001) days post-surgery. Three- and five-year OS post-BCS was lower compared to mastectomy but higher than no surgery. Prognostic factors of OS for patients who underwent surgery included academic/research institutions, income ≥$63,000, hormone positive tumors, and receipt of chemotherapy and radiation therapy. Conclusion: BCS is offered to select women with non-metastatic IBC across NCDB participating hospitals. Caution is necessary while studying if surgery can be de-escalated in IBC. Standardized multidisciplinary care along with mastectomy remains the norm for patients with non-metastatic IBC. Citation Format: Fernando A. Angarita, Stephen B. Edge, Kristopher Attwood, Kazuaki Takabe, Jessica Young. Breast conserving surgery for non-metastatic inflammatory breast cancer: A National Cancer Database (NCDB) study [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P1-24-05.
Corrigendum to “Bio-inspired intestinal scavenger from microfluidic electrospray for detoxifying lipopolysaccharide” [Bioact. Mater. 6 (2020) 1653–1662]
Authors: Cheng Zhao, Guopu Chen, Huan Wang, Yuanjin Zhao, Renjie Chai
Journal: Bioactive Materials (2022)

[This corrects the article DOI: 10.1016/j.bioactmat.2020.11.017.].
COVID-19 COMPLICATED BY HIGH-GRADE ATRIOVENTRICULAR BLOCK
Authors: Ivan Mendoza, Karina Auristela Gonzalez Carta, Heliodoro Rodriguez, Igor Morr, Susana Blanco, Hildelia Hernandez, Elias Urbaez, Elio Rodriguez, Yolimar Meza, Elirub Rojas, Francesca Misticchio, Jose Miguel Torres, Ivan J. Mendoza Mujica
Journal: Journal of the American College of Cardiology (2022)
Author Correction: Sphingosine 1-phosphate modulation and immune cell trafficking in inflammatory bowel
Authors: Bram Verstockt, Stefania Vetrano, Azucena Salas, Shadi Nayeri, Marjolijn Duijvestein, Niels Vande Casteele, Silvio Danese, Geert D’Haens, Lars Eckmann, William A. Faubion, Brian G. Feagan, Vipul Jairath, Christopher Ma, Dermot McGovern, Julian Panes, William J. Sandborn, Mark S. Silverberg, Severine Vermeire
Journal: Nature Reviews Gastroenterology & Hepatology (2022)
COMPREHENSIVE COMPARATIVE EFFECTIVENESS AND SAFETY OF FIRST-LINE ANTIHYPERTENSIVE MONOTHERAPY IN HYPERTENSIVE PATIENTS: A LARGE-SCALE MULTINATIONAL PARTICIPANT-LEVEL ASSESSMENT
Authors: Yuan Lu, Rohan Khera, Yuntian Liu, Ruijun Chen, Martijn Schuemie, George Hripcsak, Marc Suchard, Harlan M. Krumholz
Journal: Journal of the American College of Cardiology (2022)
Polo‐like kinase 4 inhibitor CFI‐400945 suppresses liver cancer through cell cycle perturbation and eliciting antitumor immunity
Authors: Cerise Yuen‐Ki Chan, Vincent Wai‐Hin Yuen, David Kung‐Chun Chiu, Chi‐Ching Goh, Kelsie L. Thu, David W. Cescon, Isabel Soria‐Bretones, Cheuk‐Ting Law, Jacinth Wing‐Sum Cheu, Derek Lee, Aki Pui‐Wah Tse, Kel Vin Tan, Misty Shuo Zhang, Bowie Po‐Yee Wong, Chun‐Ming Wong, Pek‐Lan Khong, Irene Oi‐Lin Ng, Mark R. Bray, Tak Wah Mak, Thomas Chung‐Cheung Yau, Carmen Chak‐Lui Wong
Journal: Hepatology (2022)

Prognosis of HCC remains poor due to lack of effective therapies. Immune checkpoint inhibitors (ICIs) have delayed response and are only effective in a subset of patients. Treatments that could effectively shrink the tumors within a short period of time are idealistic to be employed together with ICIs for durable tumor suppressive effects. HCC acquires increased tolerance to aneuploidy. The rapid division of HCC cells relies on centrosome duplication. In this study, we found that polo-like kinase 4 (PLK4), a centrosome duplication regulator, represents a therapeutic vulnerability in HCC.An orally available PLK4 inhibitor, CFI-400945, potently suppressed proliferating HCC cells by perturbing centrosome duplication. CFI-400945 induced endoreplication without stopping DNA replication, causing severe aneuploidy, DNA damage, micronuclei formation, cytosolic DNA accumulation, and senescence. The cytosolic DNA accumulation elicited the DEAD box helicase 41-stimulator of interferon genes-interferon regulatory factor 3/7-NF-κβ cytosolic DNA sensing pathway, thereby driving the transcription of senescence-associated secretory phenotypes, which recruit immune cells. CFI-400945 was evaluated in liver-specific p53/phosphatase and tensin homolog knockout mouse HCC models established by hydrodynamic tail vein injection. Tumor-infiltrated immune cells were analyzed. CFI-400945 significantly impeded HCC growth and increased infiltration of cluster of differentiation 4-positive (CD4 + ), CD8 + T cells, macrophages, and natural killer cells. Combination therapy of CFI-400945 with anti-programmed death-1 showed a tendency to improve HCC survival.We show that by targeting a centrosome regulator, PLK4, to activate the cytosolic DNA sensing-mediated immune response, CFI-400945 effectively restrained tumor progression through cell cycle inhibition and inducing antitumor immunity to achieve a durable suppressive effect even in late-stage mouse HCC.
CHILDREN ARE LESS LIKELY THAN ADULTS TO DEVELOP HEART BLOCK FOLLOWING TAVR
Authors: Claire Newlon, Mary Niu, Edem Binka, Dana Boucek, Zhining Ou, Susan P. Etheridge, Thomas A. Pilcher, Mary Hunt Martin, Robert G. Gray, S. Yukiko Asaki
Journal: Journal of the American College of Cardiology (2022)
COMPUTATIONAL MODELING OF CORONARY OBSTRUCTION IN VALVE-IN-VALVE TAVR: CHOOSING THE RIGHT VIRTUAL VALVE TO CORONARY DISTANCE
Authors: Sri Krishna Sivakumar, Pradeep Yadav, Venkateshwar R. Polsani, Vinod H. Thourani, Lakshmi Prasad Dasi
Journal: Journal of the American College of Cardiology (2022)
HSR22-165: Pulmonary Function Tests (PFTs) and Immune Checkpoint Inhibitor Pneumonitis
Authors: Maria Kathleen Riley, Alex Wong, Songzhu Zhao, Jing Wang, Vince Esguerra, Mingjia Li, Kari Kendra, Gabrielle Lopez, Carolyn Presley, Lai Wei, Dwight Owen, Kevin Ho
Journal: Journal of the National Comprehensive Cancer Network (2022)