POS1074 CARDIOVASCULAR RISK FACTORS IN A MEXICAN MESTIZO PATIENTS WITH PSORIATIC ARTHRITIS
Authors: S. Lugo-Perez, I. J. Colunga-Pedraza, J. R. Azpiri-López, D. Á. Galarza-Delgado, A. B. Rodriguez-Romero, N. Guajardo-Jauregui, D. E. Flores Alvarado, A. Cárdenas, O. Ilizaliturri Guerra
Journal: Annals of the Rheumatic Diseases (2021)

Background: Psoriatic Arthritis (PsA) is a chronic inflammatory arthropathy that affects 14%-30% of patients with skin and/or nail psoriasis. Patients with psoriatic arthritis (PsA) have a higher prevalence of traditional cardiovascular (CV) risk factors and an increased risk of developing cardiovascular diseases (1), such as acute myocardial infarction, cerebrovascular accident, peripheral vascular disease and heart failure. Despite the evidence patients with PsA are inadequately screened and undertreated for CV risk factors (CVRF), highlighting a gap in preventive medicine to adjust cardiovascular therapies(2). Objectives: The aim of the study is to determine the main CVRF in Mexican Mestizo patients with a diagnosis of PsA and to compare it with healthy controls. Additionally, to assess the impact of the diagnosis of PsA on the presence on these cardiovascular comorbidities. Methods: A cross-sectional, observational, and comparative study of ninety-six patients with PsA between 40-75 years who fulfilled CASPAR criteria 2006. Patients were matched by age and gender with non-PsA subjects. A medical history and physical exam were performed, also a blood sample was collected during the first visit. Chi square and Student´s t test were used for comparations between groups. A binary logistic regression was performed including the traditional CVRF (type 2 diabetes mellitus, hypertension, obesity, and active smoking), age and the diagnosis of PsA. A p value &lt;0.05 was considered statistically significant. Results: There were 58 (60.4%) women in each group with a mean of 53 years. Patients with PsA showed a higher prevalence of hypertension (HTN) compared to healthy controls (35.4% vs 19.8%, respectively, p = 0.015). Additionally, there was a significant difference in the diagnosis of dyslipidemia (42.7% vs 22.9%, p = 0.003).We found no statistically difference between the two groups in type 2 diabetes mellitus, active smoking and, obesity (Table 1. below). Table 1. Comparison of cardiovascular risk factors between Psoriatic Arthritis and controls. PsA (n=96 ) Control (n=96 ) p Age, years ± SD 53.19 ± 11.13 53.34 ± 8.4 NS Women, n (%) 58 (60.4) 58 (60.4) NS T2DM, n (%) 21 (21.9) 12 (12.5) NS HTN, n (%) 34 (35.4) 19 (19.8) 0.015 Active smoking, n (%) 21 (21.9) 20 (20.8) NS Dyslipidemia, n (%) 41 (42.7) 22 (22.9) 0.003 Obesity, n (%) 36 (37.5) 25 (26.0) NS NS, no significative; SD, standard deviation; HTN, hypertension; T2DM, type2 diabetes mellitus. The binary logistic regression showed that the diagnosis of PsA (OR 2.235, 95% CI 1.141-4.375, p = 0.019) and active smoking (OR 2.429 95%, CI 1.137-5.186, p = 0.022) are independent risk factors for the presence of dyslipidemia. Conclusion: Patients with PsA have a higher prevalence of HTN and dyslipidemia. The diagnosis of PsA seems to be an independent factor for the presence of dyslipidemia. It is important for rheumatologists to identify those patients who could benefit from adjust antirheumatic and cardiovascular therapies due to their impact on morbidity and mortality. References: [1]Peluso R, Caso F, Tasso M, et al. Cardiovascular Risk Markers and Major Adverse Cardiovascular Events in Psoriatic Arthritis Patients. Rev Recent Clin Trials 2018;13(3):199-209. doi: 10.2174/1574887113666180314105511 [2]Takeshita J, Grewal S, Langan SM, et al. Psoriasis and comorbid diseases: Implications for management. J Am Acad Dermatol 2017;76(3):393-403. doi: 10.1016/j.jaad.2016.07.065 Disclosure of Interests: None declared.