tbuckley/cabot-search huggingface dataset:
Alpha-skeletal actin is associated with increased contractility in the mouse heart.
Authors: T EHewett, I LGrupp, GGrupp, JRobbins
Journal: Circulation Research (1994)

BALB/c mice express abnormally high levels of alpha-skeletal actin in the heart, which may be related to a duplication in the promoter of the alpha-cardiac actin gene. To evaluate the effects of overexpression of the alpha-skeletal actin isoform on cardiac contractile function, we studied these mice using the isolated perfused work-performing murine heart model and measured actin isoform expression in the same hearts. We quantified myocardial contractility from the maximum rate of contraction (+dP/dt) and time to peak pressure and relaxation from -dP/dt and time to half relaxation of left intraventricular pressure. Dot blots of total RNA hybridized against oligonucleotide sequences specific for either alpha-skeletal or alpha-cardiac actin mRNA showed that increased levels of alpha-skeletal actin RNA correlated significantly with increased contractility of hearts from the BALB/c mice (r = .80, n = 15, P < .001). The present study demonstrates a significant functional correlation between alpha-actin isoform...
Letter to editor: piecemeal cold snare polypectomy versus conventional endoscopic mucosal resection for large sessile serrated lesions
Authors: Haiying Guan, Chunyan Zeng, Youxiang Chen
Journal: Gut (2021)

With great interest, we read the recent study by van Hattem et al , which compared the utility in large sessile serrated lesions (L-SSL) management between piecemeal cold snare polypectomy (p-CSP) and endoscopic mucosal resection (EMR).1 We congratulate the authors for this innovative study that demonstrated the security and effection of p-CSP in the management of L-SSL and opened the door to determine the best treatment for endoscopically resecting L-SSL. Although the data and methodology of the study are impressive, there are several questions, which should be highlighted.

First, this study divided patients with L-SSL at two different times into p-CSP and EMR group. Compared with the early stage, with …
Gamma camera quantitation of thallium-210 redistribution at rest in a dog model.
Authors: R MSteingart, RBontemps, JScheuer, TYipintsoi
Journal: Circulation (1982)

Defects seen at rest on thallium-201 (201TI) scintigraphy can disappear over time. We obtained sequential 5-minute scans over 127 +/- 9.4 minutes in seven open-chest dogs with fixed, stable regional flow reductions (normal zone flow 0.76 +/- 0.09 ml g-1/min, ischemic zone flow 0.49 +/- 0.04 ml g-1 min [mean +/- SEM], p less than 0.05) as determined by microsphere injection. Sequential 5-minute scans were obtained after i.v. injection of 1.5 mCi of 201TI. Data were stored in a 64 x 64 pixel computer matrix. Qualitatively, defects that showed redistribution were seen in all dogs. Quantitatively, greater count loss from peak activity distinguished the normal zone, but overlap was great. Alternate quantitative methods using background subtraction altered the characteristics of the time-activity curves, but did not enhance the separation of ischemic from normal zones. Patterns of 201TI redistribution from gamma camera imaging are profoundly influenced by the method of quantitation. No single method of quantita...
Surgery in active infective endocarditis.
Authors: J BYoung, D EWelton, A ERaizner, TIshimori, AMontero, G AGuinn, KMattox, L OGentry, J KAlexander, R RMiller
Journal: Circulation (1979)

Controversy persists concerning the role of early surgical intervention in severe infective endocarditis (IE). We therefore reviewed 163 episodes of well-documented IE in which 32 cardiac operations were performed during the active phase of IE. Congestive heart failure (CHF) was the principal indication for surgery in 88% (28/32); systemic emboli, 1/32; and persisting sepsis, 3/32. Staphylococcus and enterococcus were the most common infecting organisms in the operative group (44% and 16% respectively). Surgical mortality (11/32,37%) did not differ (p greater than 0.05) from medical mortality (26/131,20%). All 11 operative deaths occurred in patients moribund prior to surgery, including three with preoperative cardiac arrest. Surgical patients undergoing preoperative cardiac catheterization demonstrated marked CHF: a mean left ventricular end-diastolic pressure of 25.3 mm Hg. The mean cardiac index in 8/11 surgical deaths was lower (p less than 0.05) vs surgical survivors: 2.21/min/m2 vs. 3.21/min/m2. Pos...
22P Clinical utility of ddPCR for detection of sensitizing and resistance EGFRm in pts with advanced NSCLC
Authors: M. Riudavets, V. Lamberts, E. Auclin, M. Aldea, D. Vasseur, C. Jovelet, C. Naltet, P. Lavaud, A. Gazzah, F. Aboubakar, J. Remon, E. Rouleau, L. Lacroix, M. Ngocamus, C. Nicotra, B. Besse, D. Planchard, L. Mezquita
Journal: Journal of Thoracic Oncology (2021)
Influence of acute changes in preload, afterload, contractile state and heart rate on ejection and isovolumic indices of myocardial contractility in man.
Authors: M AQuinones, W HGaasch, J KAlexander
Journal: Circulation (1976)

To determine the sensitivity of several isovolumic and ejection phase indices of myocardial contractility to loading, inotropic stimulation and heart rate in man, 14 patients (pts) were studied during cardiac catheterization with simultaneous recordings of left ventricular (LV) pressures and ultrasound dimensions. Measurements were made of instantaneous and mean circumferential fiber shortening velocity (VCF), maximal (max) rate of LV pressure rise (dP/dt), dPHdt divided by end-diastolic circumference [(dP/dt)/C], (DP/dt)/C divided by aortic valve opening pressure [(dP/dt/CP], PEAK CONTRACTILe element velocity (VCE) using total LV pressure, VCE extrapolated to zero total pressure (Vmax), VCE at a developed pressure of 10 mm Hg (VCEDP10) and dP/dt at a common isovolumic developed pressure of 40 mm Hg [(dP/dt)/DP40]. Resulta are expressed in per cent change of the mean for the group. Acute preload increase (8.6% increase in end-diastolic circumference) with volume expansion at constant heart rate in 7 pts p...
Selecting the Optimal Design for Drug Discontinuation Trials in a Setting of Advanced, Life-Limiting Illness
Authors: Purav Mody, Oanh Kieu Nguyen
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Atrioventricular conduction disturbances during hypoxia. Possible role of adenosine in rabbit and guinea pig heart.
Authors: LBelardinelli, F LBelloni, RRubio, R MBerne
Journal: Circulation Research (1980)

Adenosine and related compounds can produce atrioventricular (A-V) conduction block. Similar conduction disturbances are observed in myocardial hypoxia. To investigate the possibility that adenosine might be causally involved in hypoxic conduction disturbances, we measured A-V conduction times, subdivided into atrial-to-His bundle (A-H) and His bundle-to-ventricular (H-V) intervals, with extracellular electrodes in isolated rabbit and guinea pig hearts perfused with modified Krebs-Henseleit solution. Adenosine produced dose-dependent prolongation of A-V conduction time in both species, although guinea pig hearts responded to lower doses (10(-7) M) and showed a steeper dose-response relationship than rabbit hearts. Higher adenosine doses produced second-degree heart block in both species. Conduction delay was confined to the A-H interval, implicating action on A-V node cells. Further investigation of guinea pig hearts revealed a specific antagonism towards adenosine's effects by 10(-5) M aminophylline. Con...
Regulation of capillary perfusion by small arterioles is spatially organized.
Authors: M DFrame, I HSarelius
Journal: Circulation Research (1993)

To explore a mechanism for spatial recruitment of capillaries, this study determined whether the arterioles controlling capillary perfusion, which typically arise as sequential branches along a transverse arteriole, could respond differently from each other in situ in a spatially ordered way. Diameter changes were measured for these arterioles at a known location in the intact microvasculature in the cremaster muscle of anesthetized Golden hamsters (N = 67); each arteriole controls separate capillary groups. These arterioles all had the same concentration dependence to locally (by micropipette) applied norepinephrine (NE, 10(-9) to 10(-3) mol/L), and 10(-9) mol/L NE did not induce diameter changes when applied locally to individual vessels. However, 10(-9) mol/L NE added to the tissue superfusate, or 5% added superfusate oxygen (also locally subthreshold), each induced significant diameter changes (both constrictions and dilations), in different branches, that were presumably due to summation of individua...
Reduction of myocardial infarct size: comparison between left atrial and left ventricular bypass.
Authors: J LPennock, W EPae, W SPierce, J AWaldhausen
Journal: Circulation (1979)

A controlled study was undertaken to quantitate and compare the effect of left ventricular bypass (LVB) and left atrial bypass (LAB on left ventricular infarct volume (LVIV). After baseline studies, the left anterior descending coronary artery in each of 30 mongrel dogs was ligated 1-1.5 cm from its origin. After baseline ischemic studies, control dogs (group 1--10 dogs), LAB dogs (group 2--10 dogs), and LVB dogs (group 3--10 dogs) were monitored for four hours. Final infarct size was determined by the nitroblue tetrazolium staining technique. Heart rate, mean arterial pressure, and total systemic flow (TSF) showed no significant difference between control and left heart bypass groups. In group 1, the LVIV was 27.7 +/- 6.5 g/100 g left ventricle (LV). In group 2, left heart bypass (LHB) flow was 90 +/- 4% of TSF. The pressure time index (PTI) was 2845 +/- 52 mm Hg-sec/min. The PTI demonstrated no significant difference from cntrols. In group 2, LVIV was 22.5 +/- 6.0 g/100 g LV. LVIV was reduced 18.8% from...
Efficacy and safety of dolutegravir with emtricitabine and tenofovir alafenamide fumarate or tenofovir disoproxil fumarate, and efavirenz, emtricitabine, and tenofovir disoproxil fumarate HIV antiretroviral therapy regimens started in pregnancy (IMPAACT 2010/VESTED): a multicentre, open-label, randomised, controlled, phase 3 trial
Authors: Shahin Lockman, Sean S Brummel, Lauren Ziemba, Lynda Stranix-Chibanda, Katie McCarthy, Anne Coletti, Patrick Jean-Philippe, Ben Johnston, Chelsea Krotje, Lee Fairlie, Risa M Hoffman, Paul E Sax, Sikhulile Moyo, Nahida Chakhtoura, Jeffrey SA Stringer, Gaerolwe Masheto, Violet Korutaro, Haseena Cassim, Blandina T Mmbaga, Esau João, Sherika Hanley, Lynette Purdue, Lewis B Holmes, Jeremiah D Momper, Roger L Shapiro, Navdeep K Thoofer, James F Rooney, Lisa M Frenkel, K Rivet Amico, Lameck Chinula, Judith Currier, Brookie M. Best, Cheryl Blanchette, Renee Browning, Yao Cheng, Andee Fox, Nagawa Jaliaah, Kevin Knowles, Mark Mirochnick, William A. Murtaugh, Emmanuel Patras, Mauricio Pinilla, Jean van Wyk, Frances Whalen
Journal: The Lancet (2021)
Effect of spatial variations in shear on diffusion at the wall of an arterial branch.
Authors: M HFriedman, L WEhrlich
Journal: Circulation Research (1975)

The effect of spatially varying shear on transport to the wall of a two-dimensional branch was examined, using oxygen as the test solute and the results of earlier fluid mechanical calculations to provide the shear profiles in a region characterizing the aortic bifurcation. The numerical technique employed allowed both blood-phase and mural resistances to solute uptake to be treated simultaneously and self-consistently. The calculated profiles of wall concentration and mural flux were significantly different from those which would have obtained if the shear had been uniform. The calculations suggest that, even when solute is rapidly taken up from the blood, the occasional high-shear and flow-development sites encountered along the arterial tree prevent the diffusion boundary layer adjacent to the wall from thickening to the point at which nutrition is compromised. The indirect effect of arterial geometry on transport, consequent to its direct effect on the magnitude and the distribution of the relevant he...
Proximal Lower-Limb Weakness in Charcot-Marie-Tooth Disease
Authors: José Berciano, Elena Gallardo
Journal: JAMA Neurology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Is Endoscopy Overestimating Colorectal Polyp Size?
Authors: A Hammami, A Hassine, F Zinelabidine, W Ben Ameur, W Dahmani, N Elleuch, A Ben Slama, M Ksiaa, A Braham, S Ajmi, H Jaziri, A Jmaa
Journal: Endoscopy (2021)

Aims Polyp size ≥1 cm triggers more frequent colonoscopic surveillance, yet size is typically based on subjective endoscopic estimates. The aim of this study was to compare contemporary assessments of polyp size by endoscopic estimation and pathology measurement.
Effect of platelet factors on migration of cultured bovine aortic endothelial and smooth muscle cells.
Authors: LBell, J AMadri
Journal: Circulation Research (1989)

Endothelial cell (EC) injury and the response of EC and smooth muscle cells (SMCs) to injury contribute to the pathophysiology in patients with vascular disease and atherosclerosis. Since platelets have been suggested to play an important role in modulating vascular injury, the present study was undertaken to examine the influence and mechanism of action of individual platelet factors on bovine aortic EC and SMC migration using an in vitro wound assay system. Serotonin decreased EC proliferation and reduced EC migration 21 +/- 1% (p less than 0.005), which was attenuated by imipramine. Transforming growth factor-beta reduced EC proliferation and decreased EC migration 52 +/- 3% (p less than 0.005). Norepinephrine increased EC proliferation but decreased EC migration 26 +/- 2% (p less than 0.005), which was abolished by phenoxybenzamine. Histamine increased EC proliferation but reduced EC migration 29 +/- 2% (p less than 0.005), which was attenuated by diphenhydramine. Platelet-derived growth factor decrea...
Cataracts after renal transplantation.
Authors: V G Millet, S Casado Perez, J Alvarez Grande, L Hernando Avendano
Journal: BMJ (1972)

sharply.Indeed there was one fewer in 1963 than in 1953, though there had been some increase in 1961 and 1962.The 10 years' operative mortality was 0-87 % and the morbidity due to chest infection, wound infection, and deep venous thrombosis was 9-8%.I can confirm the finding of a high proportion of stones at operation (97 4% in 1960), whereas only 29% had been demonstrated radiologically preoperatively in tiat year.The most striking feature of 1960 was that there were no operative cholangiograms carried out.Indeed, 1961 was the first year they were done at Frenchay, though only 11 were done in the subsequent three years.This led to 37-6% of all common bile ducts being explored, half of these unnecessarily.As operative cholangiography is now routine during all cholecystectomies at that hospital it would be interesting to compare the 1960 and 1970 total figures with special reference to the problem of recurrent common-bile-duct stones.-Iam, etc.,
Experimental evidence for regional cardiac influence in body surface isopotential maps of dogs.
Authors: J AAbildskov, M JBurgess, R LLux, R FWyatt
Journal: Circulation Research (1976)

Isopotential mpas based on 192-200 body surface electrocardiograms were obtained for 20 dogs during multiple patterns of ventricular activation. The purposes of the study were to determine whether the cardiac location of events responsible for surface potentials had a recognizable influence on surface potential patterns and to examine the influence of electrical events occurring simultaneously in multiple cardiac regions. Substantially different effects of electrical activity in various cardiac regions on body surface potentials were evidenced by the body surface location of potential maxima and minima and by patterns of isopotential lines during early portions of ventricular excitation initiated at different ventricular sites. Simultaneous stimulation at some sites gave surface potential distributions with multiple extrema. These were demonstrated to be due to effects of the different cardiac regions, because addition of potentials due to stimulation of the individual sites duplicated those associated wi...
Social Environment and Health.
Journal: Annals of Internal Medicine (1981)

Durant 40 ans, la recherche sur les maladies coronariennes a necessite une aide financiere colossale, et plusieurs facteurs de risques ont ete identifies, dont le tabac, la tension arterielle, l'exces de cholesterol, ainsi que d'autres facteurs tels que l'obesite, le diabete, l'inactivite physique, le stress...Outre ces facteurs, des etudes epidemiologiques pourraient egalement mettre en cause l'environnement social qui peut etre determinant pour le bien-etre et la sante
Identification of myocardial reperfusion with echo planar magnetic resonance imaging. Discrimination between occlusive and reperfused infarctions.
Authors: MSaeed, M FWendland, K KYu, KLauerma, H TLi, NDerugin, F MCavagna, C BHiggins
Journal: Circulation (1994)

BACKGROUNDThe current treatment of many cases of acute myocardial infarction involves the use of thrombolytic agents. Evaluation of this therapy requires determination of the success of reperfusion and assessment of the presence and extent of infarction in the reperfused territory. The present study was designed to simulate in rat models several possible outcomes of reperfusion therapy: (1) successful reperfusion and absence of myocardial infarction, (2) successful reperfusion and presence of myocardial infarction, and (3) unsuccessful reperfusion. The usefulness of contrast-enhanced fast magnetic resonance (MR) imaging in defining the success of reperfusion was investigated. The dynamic effects were examined of low and high doses of gadolinium-BOPTA/dimeglumine (Gd-BOPTA/dimeg) on myocardial signal using MR inversion recovery echo planar imaging (IR-EPI) and gradient recalled echo planar imaging (GR-EPI), respectively.METHODS AND RESULTSRats were subjected to one of the following regimens: reperfused rev...
Participating in execution and medical ethics.
Authors: F de Zulueta
Journal: BMJ (1980)

maximum part-time contracts" he states that "'many regions regard travel, administration, and emergency duties as representing two NHDs weekly for the generality of maximum part-time consultants."This seems to indicate that in those many regions maximum part- time consultants will be contracted to work for 28 hours in order to qualify for 10/1 lths of the whole-time salary.It would be helpful if Mr Bolt could com-
The effects of morphine on venous tone in patients with acute pulmonary edema.
Authors: L AVismara, D MLeaman, RZelis
Journal: Circulation (1976)

In order to compare the venodilation effect of morphine in normal individuals (22) with that in patients (13) with heart failure morphine sulfate (0.1 mg/kg) was administered to 13 patients with mild pulmonary edema. After morphine congestive symptoms improved and venodilation was induced as determined by two independent techniques: venous pressure fell 10.2 mm Hg by the isolated hand technique and the venous volume of the forearm increased by 0.48 cc/100 ml, measured by equilibration technique. Neither finding differed from those in normal individuals. Reflex venoconstriction noted on the taking of a single deep breath was unaffected by morphine administration and was similar to that observed in normal subjects. Since the drug morphine sulfate does not cause a major pooling of blood in the limbs, the favorable effect of narcotics in patients with pulmonary edema must be caused by other mechanisms such as splanchnic pooling, afterload reduction or reduced breathing effort.
Electrophysiological effects of adenosine in the transplanted human heart. Evidence of supersensitivity.
Authors: K AEllenbogen, M DThames, J PDiMarco, HSheehan, B BLerman
Journal: Circulation (1990)

After cardiac transplantation, the denervated donor atria and ventricles demonstrate increased sensitivity to infusions of sympathomimetic amines. Recently, supersensitivity of the canine sinus and atrioventricular (AV) nodes to acetylcholine has also been demonstrated after parasympathetic denervation. Acetylcholine and the endogenous nucleoside adenosine exert similar electrophysiological effects in both the sinus and AV nodes, and share a common transduction process. We, therefore, hypothesized that after orthotopic cardiac transplantation, the donor (denervated) sinus node would demonstrate greater sensitivity to exogenous adenosine than the recipient (innervated) sinus node. The effects of incremental doses of intravenous adenosine (37-112 micrograms/kg) on changes in sinus cycle length (SCL) (delta SCLmax%), changes in PR interval (delta PRmax%), time to peak effect (sec), and duration of electrophysiological effects (sec) were prospectively measured in 28 orthotopic cardiac transplant patients and ...