tbuckley/cabot-search huggingface dataset:
Short- and long-term clinical outcome after Q wave and non-Q wave myocardial infarction in a large patient population.
Authors: PNicod, EGilpin, HDittrich, RPolikar, AHjalmarson, A RBlacky, HHenning, JRoss
Journal: Circulation (1989)

Prognosis for patients with non-Q wave myocardial infarction is controversial although a number of studies have shown a less favorable outlook after hospital discharge for patients with non-Q wave than for those with Q wave infarction. Therefore, the in-hospital and 1-year prognosis was investigated in a sufficiently large patient population (n = 2,024) to allow stratification by subgroups, in particular by age and previous myocardial infarction. Patients with non-Q wave infarction (n = 444; 22% of the total study population) were somewhat older (65 vs. 63 years, p less than 0.001) and had an increased incidence of previous myocardial infarction (46% vs. 24%, p less than 0.001) and congestive heart failure (21% vs. 8%, p less than 0.001) than patients with Q wave infarction. In-hospital mortality of patients with non-Q wave infarction was lower (8.1% vs. 11.5%; p less than 0.06), whereas their 1-year mortality after hospital discharge was significantly higher (13.7% vs. 9.2%, p less than 0.05) than for pa...
Safety and Efficacy of Colonoscopy in Nonagenarians in a Secondary Center
Authors: M Coelho, E Dantas, C Sequeira, I Santos, R Freire, I Cremers, A Oliveira
Journal: Endoscopy (2021)

Aims Colonoscopy is considered the gold standard for colorectal examination. However, even with life expectancy increasing globally, data concerning performance, diagnostic yield and safety of colonoscopy in the elderly population is still scarce.
Clinical competence in ambulatory electrocardiography. A statement for physicians from the AHA/ACC/ACP Task Force on Clinical Privileges in Cardiology.
Authors: S BKnoebel, S VWilliams, J LAchord, W AReynolds, CFisch, G CFriesinger, F JKlocke, MAkhtar, T JRyan, R CSchlant
Journal: Circulation (1993)
Virtual Chromoendoscopy for Characterization of Colorectal Polyps: Interobserver Reliability Betweeln Junior and Senior Endoscopist
Authors: I Ferchichi, M Sabbah, F Ben Farha, N Bellil, D Trad, N Bibani, A Ouakaa, H Elloumi, D Gargouri
Journal: Endoscopy (2021)

Aims Endoscopic assessment of colorectal polyps’ histology based on virtual chromoendoscopy is basically allowed to “experts” only, due to a possible inter-observer variability. This study aims to assess virtual chromoendoscopy performance in colorectal polyps characterization and to evaluate the interobserver reliability between junior and senior endoscopist.
Organ donation after circulatory death: please avoid undue haste!
Authors: Beatriz Domínguez-Gil, Alex R. Manara, Francis L. Delmonico, Beatriz Domínguez-Gil, Nancy Ascher, Alexander M. Capron, Dale Gardiner, Alexander R. Manara, James L. Bernat, Eduardo Miñambres, Jeffrey M. Singh, Robert J. Porte, James F. Markmann, Kumud Dhital, Didier Ledoux, Constantino Fondevila, Sarah Hosgood, Dirk Van Raemdonck, Shaf Keshavjee, James Dubois, Andrew McGee, Galen V. Henderson, Alexandra K. Glazier, Stefan G. Tullius, Sam D. Shemie, Francis L. Delmonico
Journal: Intensive Care Medicine (2021)
Characteristics of binding of endothelin-1 and endothelin-3 to rat hearts. Developmental changes in mechanical responses and receptor subtypes.
Authors: TIshikawa, L MLi, OShinmi, SKimura, MYanagisawa, KGoto, TMasaki
Journal: Circulation Research (1991)

Endothelin-1 (ET-1) and endothelin-3 (ET-3) produced positive inotropic effects on electrically stimulated left atria and increased the frequency of spontaneously beating right atria of adult rats. The potency of the inotropic effect of ET-1 was greater than that of ET-3, but the potencies of the chronotropic effects of ET-1 and ET-3 were not significantly different. In the neonatal atria, ET-1 and ET-3 also induced positive inotropic and chronotropic responses. ET-1 and ET-3 showed weak or no cardiotonic effects on the adult ventricles, whereas they caused marked positive inotropy in the neonatal ventricles. The characteristics of binding sites for ET-1 and ET-3 were very similar between the atria and the ventricles of the rat neonate. Saturation and competition binding experiments have shown that neonatal cardiac membranes from both atria and ventricle have two distinct binding sites for endothelin, that is, a low-affinity and a high-affinity site. ET-1 was found to bind to the low-affinity sites with a...
Chronic pulmonary thromboembolism in dogs treated with tranexamic acid.
Authors: K MMoser, J PCantor, MOlman, IVillespin, J LGraif, RKonopka, J JMarsh, CPedersen
Journal: Circulation (1991)

BACKGROUNDMany questions remain regarding the pathogenesis, natural history, diagnosis, and treatment of chronic thromboembolic pulmonary hypertension in patients. To answer such questions, we developed an animal model of this disorder. The brisk thrombolytic response of canines to acute embolism has, previously, prevented the establishment of such a model.METHODS AND RESULTSThe fibrinolytic inhibitor tranexamic acid was given orally to canines before, and for intervals after, pulmonary emboli were released from venous thrombi formed in vivo in femoral veins or the inferior vena cava. Preliminary studies disclosed that embolic residuals from femoral vein thrombi were not sufficient to cause significant, persistent pulmonary hypertension. With repetitive, larger thrombi embolized from the inferior vena cava, however, persistent pulmonary hypertension was achieved in most animals.CONCLUSIONSResolution of emboli in the canine can be inhibited by tranexamic acid. As in humans, a spectrum of embolic residuals ...
Verapamil prevents slowing of transmural conduction and suppresses arrhythmias in an isolated guinea pig ventricular model of ischemia and reperfusion.
Authors: G RLi, G RFerrier
Journal: Circulation Research (1992)

Transmembrane electrical activity was recorded from endocardium and epicardium of isolated segments of guinea pig right ventricular free walls. An electrocardiogram was recorded by electrodes at opposite ends of the tissue bath. Endocardium was stimulated. Tissues were exposed to  conditions (e.g., acidosis, hyperkalemia, hypoxia, and lactate) for 15 minutes and then were reperfused with normal Tyrode's solution. Arrhythmias with characteristics of transmural reentry occurred in ischemic conditions and early reperfusion in 30% and 70% of 20 control hearts, respectively. Arrhythmias were associated with prolongation of transmural conduction time (CT) and abbreviation of endocardial effective refractory period. Verapamil significantly suppressed reperfusion arrhythmias at 0.1-1.0 microM but not at 3.0 microM. Verapamil also significantly decreased the incidence of arrhythmias during ischemic conditions at 0.5 microM but significantly promoted ischemic arrhythmias at 3.0 microM. Action potential ...
Comparison of the Efficacy and Safety Between Oral Sulphate Solution (OSS) and Polyethylene Glycol Electrolyte (PGE-E) as Bowel Cleansing Agent
Authors: Z Ye, M Fandong, W Yongdong, W Bangmao, S Xizhong, C Yi, Z Guoxin, Y Ai’ming, T De’an, C Jianting, W Huahong, T Ponchon, C Pommier, C Shihua, Z Shutian
Journal: Endoscopy (2021)

Aims In China, Polyethylene Glycol Electrolyte (PEG-E) is the primary recommended bowel cleansing agent but patient compliance may be influenced by poor taste and large volume (3-4L). This study aimed to compare the efficacy and safety of oral sulphate solution (OSS, a low volume agent with fruit favor) to PEG-E on bowel cleansing before colonoscopy in Chinese population.
TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation
Authors: Lorenza Magno, Tom D. Bunney, Emma Mead, Fredrik Svensson, Magda N. Bictash
Journal: Molecular Neurodegeneration (2021)

Abstract The central role of the resident innate immune cells of the brain (microglia) in neurodegeneration has become clear over the past few years largely through genome-wide association studies (GWAS), and has rapidly become an active area of research. However, a mechanistic understanding (gene to function) has lagged behind. That is now beginning to change, as exemplified by a number of recent exciting and important reports that provide insight into the function of two key gene products – TREM2 (Triggering Receptor Expressed On Myeloid Cells 2) and PLCγ2 (Phospholipase C gamma2) – in microglia, and their role in neurodegenerative disorders. In this review we explore and discuss these recent advances and the opportunities that they may provide for the development of new therapies.
Reperfusion alters the relation between blood flow and the remaining myocardial infarction.
Authors: AChu, F RCobb
Journal: Circulation (1989)

This study evaluated whether or not reperfusion of ischemic myocardium 2 hours after occlusion alters the basic relation between myocardial blood flow and infarction occurring during permanent occlusion. Awake mongrel dogs chronically instrumented with proximal circumflex coronary occluders were subjected to permanent occlusion (group A, n = 10) or occlusion followed by reperfusion 2 hours later (group B, n = 11). Myocardial blood flow was quantified with radioactive microsphere injections before, 6 hours after occlusion (group A), immediately before release, and 4 hours after reperfusion (group B). Three days later, the dogs were killed, and the heart was sectioned systematically into approximately 80 1-2-g circumferential and transmural samples for radioactive counting and histologic infarct quantification. Epimyocardial and endomyocardial samples from the permanent occlusion group (A) and the reperfused group (B) were separated by infarct range and related to regional myocardial blood flow measurements...
Adenosine deaminase and carcinoembryonic antigen in pericardial effusion diagnosis, especially in suspected tuberculous pericarditis.
Authors: K KKoh, E JKim, C HCho, M JChoi, S KCho, S SKim, M HKim, C JLee, S HJin, J MKim
Journal: Circulation (1994)

BACKGROUNDAdenosine deaminase (ADA) and carcinoembryonic antigen (CEA) have been measured in pleural fluid to help distinguish malignant from benign effusions, especially in tuberculous pleurisy. We investigated ADA and CEA levels in patients with moderate to large pericardial effusions of different etiologies.METHODS AND RESULTSWe performed diagnostic and therapeutic pericardiostomy with drainage and biopsy. We measured ADA and CEA levels in the pericardial fluid in 26 patients with moderate to large pericardial effusion and 19 control patients. Patients were included in a prospective protocol from August 1991 to August 1993. Patients were grouped as follows: group 1, 9 patients with tuberculous pericarditis (TP) confirmed by bacteriologic culture or histology of pericardial biopsy; group 2, 5 patients with clinically strongly suspected TP; group 3, 12 patients with malignancy (8) and acute pericarditis (4); group 4, 19 control patients without pericardial disease. We treated patients with TP with isonia...
Emergency stenting for acute occlusion after coronary balloon angioplasty.
Authors: USigwart, PUrban, SGolf, UKaufmann, CImbert, AFischer, LKappenberger
Journal: Circulation (1988)

Acute coronary artery occlusion complicates 2-12% of the balloon angioplasty procedures, and despite repeat angioplasty, emergency surgical revascularization is often necessary. We report our initial experience with the emergency implantation of endoluminal stents for acute vessel closure after coronary balloon angioplasty. Nine patients received one stent, and two patients received two stents during the study period. Implantation was technically successful in all patients; there were no deaths, no myocardial infarctions as evidenced by Q wave on the electrocardiogram, and no need for emergency surgery. One additional patient, not satisfying the study inclusion criteria, died 16 hours after stent implantation from left ventricular failure and intractable arrythmias. Two patients in the study group had a moderate creatinine phosphokinase rise during the first 48 hours after implantation. During a median follow-up period of 3 months (range, 1-20 months), there have been no deaths and no need for elective co...
Transmural distribution of isomyosin in rabbit ventricle during maturation examined by immunofluorescence and staining for calcium-activated adenosine triphosphatase.
Authors: B REisenberg, J AEdwards, RZak
Journal: Circulation Research (1985)

Mammalian ventricle contains two major isomyosins, V1 and V3, which differ in the primary structure of their heavy chains (HC alpha alpha and HC beta beta, respectively) and in their adenosine triphosphatase activity. The distribution of the HC alpha isomyosin in the left ventricle of the rabbit was followed as a function of age and transmural location. HC alpha was detected with a monoclonal antibody found to be specific for the hinge region of V1 myosin molecules when viewed in the electron microscope after low-angle rotary shadowing. Frozen sections were observed with indirect immunofluorescence developed to this anti-HC alpha hinge antibody. Serial sections were observed with the histochemical assay for calcium-activated myosin adenosine triphosphatase, using preincubation at various pH levels. Results show that all the ventricular myocytes in baby rabbits (2 weeks) are stained by the HC alpha-antibody from the epi- to endocardium. The isomyosin content of myocytes varies through the epi- to endocardi...
Inhaled nitric oxide in congenital heart disease.
Authors: J DRoberts, PLang, L MBigatello, G JVlahakes, W MZapol
Journal: Circulation (1993)

BACKGROUNDCongenital heart lesions may be complicated by pulmonary arterial smooth muscle hyperplasia, hypertrophy, and hypertension. We assessed whether inhaling low levels of nitric oxide (NO), an endothelium-derived relaxing factor, would produce selective pulmonary vasodilation in pediatric patients with congenital heart disease and pulmonary hypertension. We also compared the pulmonary vasodilator potencies of inhaled NO and oxygen in these patients.METHODS AND RESULTSIn 10 sequentially presenting, spontaneously breathing patients, we determined whether inhaling 20-80 ppm by volume of NO at inspired oxygen concentrations (FIO2) of 0.21-0.3 and 0.9 would reduce the pulmonary vascular resistance index (Rp). We then compared breathing oxygen with inhaling NO. Inhaling 80 ppm NO at FIO2 0.21-0.3 reduced mean pulmonary artery pressure from 48 +/- 19 to 40 +/- 14 mm Hg and Rp from 658 +/- 421 to 491 +/- 417 dyne.sec.cm-5.m-2 (mean +/- SD, both p < 0.05). Increasing the FIO2 to 0.9 without adding NO did not...
Assessment of Pembrolizumab Therapy for the Treatment of Microsatellite Instability–High Gastric or Gastroesophageal Junction Cancer Among Patients in the KEYNOTE-059, KEYNOTE-061, and KEYNOTE-062 Clinical Trials
Authors: Joseph Chao, Charles S. Fuchs, Kohei Shitara, Josep Tabernero, Kei Muro, Eric Van Cutsem, Yung-Jue Bang, Ferdinando De Vita, Gregory Landers, Chia-Jui Yen, Ian Chau, Anneli Elme, Jeeyun Lee, Mustafa Özgüroglu, Daniel Catenacci, Harry H. Yoon, Erluo Chen, David Adelberg, Chie-Schin Shih, Sukrut Shah, Pooja Bhagia, Zev A. Wainberg
Journal: JAMA Oncology (2021)

Immunotherapy has been associated with improved outcomes among patients who have received previous treatment for microsatellite instability-high (MSI-H) tumors.
Alpha 1-adrenoceptor stimulation enhances the delayed rectifier K+ current of guinea pig ventricular cells through the activation of protein kinase C.
Authors: NTohse, HNakaya, MKanno
Journal: Circulation Research (1992)

The effect of alpha 1-adrenoceptor stimulation on the delayed rectifier K+ current (IK) was examined in isolated guinea pig ventricular cells by use of the patch-clamp method. IK was evoked by a 3-second depolarizing pulse from a holding potential of -30 mV in a Na(+)- and K(+)-free solution containing 3 microM nifedipine. Phenylephrine (30 microM) in the presence of propranolol (1 microM) produced an increase in IK. In five cells, phenylephrine increased the tail current of IK by 23 +/- 5%. This effect of phenylephrine was blocked by prazosin (0.3 microM), a selective alpha 1-blocker. Phenylephrine produced only a small effect on the voltage and time dependence of IK. Pretreatment with 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7, 10 microM) abolished the phenylephrine-induced increase in IK. In addition, pretreatment with a maximally effective concentration of 12-O-tetradecanoylphorbol 13-acetate (100 nM) abolished the phenylephrine-induced increase in IK. In conclusion, alpha 1-adrenoceptor stim...
Echo-wave termination of ventricular tachycardia. A common mechanism of termination of reentrant arrhythmias by various pharmacological interventions.
Authors: JBrugada, LBoersma, HAbdollah, CKirchhof, MAllessie
Journal: Circulation (1992)

BACKGROUNDBased on epicardial mapping, different mechanisms of termination of reentrant ventricular tachycardia by various pharmacological interventions are described.METHODS AND RESULTSIn 40 Langendorff-perfused rabbit hearts, rings of anisotropic left ventricular epicardium were made by a cryoprocedure. Sustained monomorphic ventricular tachycardia based on continuous circus movement of the impulse around the ring was induced by programmed stimulation. Increasing doses of heptanol (n = 10), potassium (n = 10), tetrodotoxin (n = 6), RP62719 (a new class III drug) (n = 4), flecainide (n = 5), and propafenone (n = 5) were administered to terminate ventricular tachycardia. Epicardial mapping (248 points) was used to study the mechanism of termination of ventricular tachycardia. In 28 of 40 hearts, ventricular tachycardia terminated because the drugs produced complete conduction block of the impulse in a segment of the reentrant pathway. In the remaining 12 hearts (heptanol, n = 2; potassium, n = 3; tetrodot...
Clinical gastroenterology and hepatology
Authors: J. de Caestecker
Journal: Gut (2007)

STUDY OBJECTIVE--The aim was to analyse the relationship between partial gastrectomy and gastric cancer risk. DESIGN--This was a case control study, using a structured questionnaire to obtain problem orientated medical history and sociodemographic data. SETTING--The study was conducted in a network of hospitals in the Greater Milan area between January 1985 and February 1990. SUBJECTS--Subjects were 563 incident cases of histologically confirmed gastric carcinoma (347 males, 216 females, median age 60 years, range 28 to 74) and 1501 controls (885 males, 626 females, median age 58 years, range 23 to 74) in hospital for acute, non-neoplastic, non-digestive-tract disorders. Less than 3% of cases or controls refused to be interviewed. MEASUREMENTS AND MAIN RESULTS--Relative risks (RR) and the corresponding 95% confidence intervals (CI) were determined, adjusted for age and sex plus area of residence, education, and smoking when specified. Within 20 years after gastrectomy, the relative risk of gastric cancer was not significantly raised (RR = 1.2, 95% CI 0.5-2.8), but a positive association emerged after longer time intervals. The RR was 1.6 (95% CI 0.7-4.1) after 20 to 29 years, and 3.5 (95% CI 1.3-10.0) after 30 years or more. These results were consistent in the two sexes and in the subsequent age groups, and not materially influenced by allowance for a number of identified potential confounding factors using multivariate analysis. CONCLUSIONS--The risk of gastric cancer is increased in the long term (20 years or more) after gastrectomy. This is explainable in terms of increased intragastric carcinogen formation following gastrectomy, and/or potential similarities in aetiological correlates of gastric ulcer and carcinoma of the stomach.
Clonal Hematopoiesis and Risk of Progression of Heart Failure With Reduced Left Ventricular Ejection Fraction
Authors: Domingo A. Pascual-Figal, Antoni Bayes-Genis, Miriam Díez-Díez, Álvaro Hernández-Vicente, David Vázquez-Andrés, Jorge de la Barrera, Enrique Vazquez, Ana Quintas, María A. Zuriaga, Mari C. Asensio-López, Ana Dopazo, Fátima Sánchez-Cabo, José J. Fuster
Journal: Journal of the American College of Cardiology (2021)
Chronic reduction of myocardial ischemia does not attenuate coronary collateral development in miniswine.
Authors: J DSymons, K FPitsillides, J CLonghurst
Journal: Circulation (1992)

BACKGROUNDMyocardial ischemia is considered to be a possible stimulus for development of the coronary collateral circulation. We therefore hypothesized that chronic reduction of myocardial oxygen demand to lessen ischemia would attenuate coronary collateral development over an 8-week period using left circumflex coronary artery (LCx) ameroid-induced constriction in pigs.METHODS AND RESULTSCollateral development was assessed by myocardial blood flow (radioactive microspheres) and left ventricular regional function (sonomicrometer dimension gauges). beta-Adrenoceptor blockade with propranolol (160 or 320 mg b.i.d.p.o.) was initiated in 15 animals 1 day after surgery. Compared with 16 untreated animals, beta-adrenoceptor antagonism was documented in the treated group by 1) pharmacological stimulation with isoproterenol, 2) physiological stimulation during graded treadmill exercise, and 3) repeated long-term biotelemetry recordings of oxygen demand (heart rate and blood pressure) and regional myocardial funct...
Abstract 12896: Association of Automated Deep Learning Coronary Artery Calcium Score on ECG-Gated and Non-ECG Gated CT With Future Cardiac Events: Insights From ROMICAT-II and NLST
Authors: Michael T Lu, Roman Zeleznik, Borek Foldyna, Parastou Eslami, Alexander Ivanov, Chintan Parmar, Jakob Weiss, Jana Taron, Raza Alvi, Dahlia Banerji, Mio Uno, Yasuka Kikuchi, Jan-Erik Scholtz, Hugo Aerts, Udo Hoffmann
Journal: Circulation (2019)

Introduction: The 2018 ACC/AHA multisociety guidelines promote the coronary artery calcium (CAC) score to inform decision-making. New developments in deep learning (DL) convolutional neural network...
CD27 is required for protective lytic EBV antigen–specific CD8+ T-cell expansion
Authors: Yun Deng, Bithi Chatterjee, Kyra Zens, Hana Zdimerova, Anne Müller, Patrick Schuhmachers, Laure-Anne Ligeon, Antonino Bongiovanni, Riccarda Capaul, Andrea Zbinden, Angelika Holler, Hans Stauss, Wolfgang Hammerschmidt, Christian Münz
Journal: Blood (2021)
Long-term oral administration of L-arginine reduces intimal thickening and enhances neoendothelium-dependent acetylcholine-induced relaxation after arterial injury.
Authors: MHamon, BVallet, CBauters, NWernert, E PMcFadden, J MLablanche, BDupuis, M EBertrand
Journal: Circulation (1994)

BACKGROUNDNitric oxide (NO), in addition to its potent vasorelaxant properties, may participate in growth regulation of cultured smooth muscle cells. It was recently demonstrated that in vivo endothelial injury induces the production of NO from L-arginine in the arterial wall.METHODS AND RESULTSWe studied the effects of long-term administration of L-arginine, the precursor of NO, on neointimal thickening and on neoendothelium-dependent vasorelaxation 4 weeks after balloon denudation of normocholesterolemic rabbit iliac arteries. Rabbits were fed with either a standard diet or a diet supplemented with L-arginine (2.25%) in their drinking water 3 days before and during 4 weeks after balloon denudation. The effectiveness of L-arginine supplementation was confirmed by measurement of plasma arginine levels. L-Arginine had no effect on hemodynamic parameters. All animals were killed 4 weeks after balloon denudation, and a digital histomorphometric analysis of three serial nonconsecutive histological cross secti...
Shall The Journal be Removed to Washington?
Authors: E. F. Clapp
Journal: JAMA (1891)

<h3>To the Editor:</h3> —I notice one of the reasons given by a subscriber for movingThe Journalto Washington, is, that " We the official representatives of the profession should keep as closely to the Government as possible." The people is the Government, and as Chicago is the centre of the people letThe Journalremain in Chicago and move the Capital near toThe Journal—that the centre be less lop-sided. Iowa City, Ia., March 21, 1891.