tbuckley/cabot-search huggingface dataset:
Anti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1
Authors: Senem Aykul, Lily Huang, Lili Wang, Nanditha M. Das, Sandra Reisman, Yonaton Ray, Qian Zhang, Nyanza Rothman, Kalyan C. Nannuru, Vishal Kamat, Susannah Brydges, Luca Troncone, Laura Johnsen, Paul B. Yu, Sergio Fazio, John Lees-Shepard, Kevin Schutz, Andrew J. Murphy, Aris N. Economides, Vincent Idone, Sarah J. Hatsell
Journal: Journal of Clinical Investigation (2022)

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder whose most debilitating pathology is progressive and cumulative heterotopic ossification (HO) of skeletal muscles, ligaments, tendons, and fascia. FOP is caused by mutations in the type I BMP receptor gene ACVR1, which enable ACVR1 to utilize its natural antagonist, activin A, as an agonistic ligand. The physiological relevance of this property is underscored by the fact that HO in FOP is exquisitely dependent on activation of FOP-mutant ACVR1 by activin A, an effect countered by inhibition of anti-activin A via monoclonal antibody treatment. Hence, we surmised that anti-ACVR1 antibodies that block activation of ACVR1 by ligands should also inhibit HO in FOP and provide an additional therapeutic option for this condition. Therefore, we generated anti-ACVR1 monoclonal antibodies that block ACVR1's activation by its ligands. Surprisingly, in vivo, these anti-ACVR1 antibodies stimulated HO and activated signaling of FOP-mutant ACVR1. This property was restricted to FOP-mutant ACVR1 and resulted from anti-ACVR1 antibody-mediated dimerization of ACVR1. Conversely, wild-type ACVR1 was inhibited by anti-ACVR1 antibodies. These results uncover an additional property of FOP-mutant ACVR1 and indicate that anti-ACVR1 antibodies should not be considered as therapeutics for FOP.
235P Resumption of menses (ROM), fertility status perception and pregnancy desire in young breast cancer survivors: A real-world data survey
Authors: K.J. Salas Espinoza, K.M. Roque Perez, Z.D. Morante Cruz, G. Valencia Mesias, P.E. Rioja Viera, H.A. Fuentes, S.P. Neciosup Delgado, J.M.M. Cotrina Concha, H.L. Gomez Moreno
Journal: Annals of Oncology (2022)
20P The importance of ARG2 expression in the immune-depleted microenvironment of primary breast cancer and brain metastasis
Authors: A. Giannoudis, D. Vareslija, V. Sharma, R. Zakaria, A. Platt-Higgins, P. Rudland, M. Jenkinson, L. Young, C. Palmieri
Journal: Annals of Oncology (2022)
24P Intermediate biopsies during neoadjuvant chemotherapy for breast cancer to predict patient outcome
Authors: B.V. Sinn, M. Untch, T. Karn, M. van Mackelenbergh, J. Huober, K. Sychra, W.D. Schmitt, F. Marmé, C. Schem, C. Solbach, E. Stickeler, H. Tesch, P.A. Fasching, A. Schneeweiss, V. Müller, V. Nekljudova, S. Loibl, C. Denkert
Journal: Annals of Oncology (2022)
TRANSRECTAL DRAINAGE OF ABDOMINAL ABSCESS
Authors: G. Torres Vicente, E. Pijoan Comas, I. Miguel Salas, A. Vargas García, N. Torres Monclús, M. Alburquerque Miranda, D.C. Bayas Pástor, D. Vázquez Gómez, N. Zaragoza Velasco, F. Gonzalez-Huix Lladó
Journal: Endoscopy (2022)

A 74-year-old woman was admitted for acute diverticulitis with polylobulated air-fluid collection with previous failure of radiological drainage. EUS-guided transrectal drainage was performed, 19G needle punction to obtain material for culture. Access to the collection with cystotome, and path dilatation with balloon up to 12mm, a first 10Fx5cm Pigtail is placed. By direct endoscopic vision, a 3-way silicone Foley nº20 tube was placed, that remained within the cavity anchored by the balloon. A second 7Fx5cm Pigtail was placed. Continuous lavage with 1000mL/day was maintained for 3 days. After 4 days CT showed nearly resolution of collections.
IMPACT OF THE RUTGEERTS SCORE ON THE MANAGEMENT OF OPERATED CROHN'S DISEASE
Authors: M. Cherkaoui Malki, H. Elbacha, S. Mechhor, B. Boubaouen, T. Gharbi, N. Benzzoubeir, I. Errabih
Journal: Endoscopy (2022)

Aims The aim of our study is to evaluate the efficacy of the strategy undertaken based on postoperative colonoscopy, and then to identify predictive factors of postoperative recurrence.
TRANSHEPATIC CHOLANGIOSCOPY-GUIDED ELECTROHYDRAULIC LITHOTRIPSY FOR LARGE COMMON BILE DUCT STONE AND ANTEGRADE DUCTAL CLEARANCE IN A PATIENT WITH DIFFICULT TRANSPAPILLARY ACCESS
Authors: S.M. Hassan, M. Hussain, M.M. Yousuf, A.W. Dogar, A. Ullah, R.B. Bhatti
Journal: Endoscopy (2022)

Aims We are reporting an innovative approach of managing large common bile duct stone through transhepatic route in a patient with inaccessible transpapillary cannulation.
QUALITY SYSTEM BASED IN ISO 9001:2015 AND THE IMPACT IN THE IMPROVEMENT OF THE INDICATORS IN A GASTROINTESTINAL ENDOSCOPY UNIT
Authors: F. Garrido, L. Adán, C. González, Á. Martínez-Alcalá, C. Zaera, J.C. Villa, M.L. Buxaderas, M.M. Gimeno, M. Aldeguer, Á. Ponferrada
Journal: Endoscopy (2022)

Aims The ISO 900:2015 is a Quality System based in the risk evaluation and the continuous improvement of the organization, but could improve the usual indicators that we have in a Gastrointestinal Endoscopy Unit? Our objective was to evaluate the improvement of some of the most usual indicators in Gastrointestinal Endoscopy in our Unit, after to get the certification ISO 900:2015 in March 2019. From the request of the endoscopy to the post procedure, including endoscope reprocessing, traceability, and the management of the tissue sampling.
PREDICTIVE FACTORS AND SURGICAL IMPACT OF COLONOSCOPY ACCURACY IN LOCALIZATION OF COLORECTAL MALIGNANCY
Authors: E. Dias, J. Santos-Antunes, D. Gonçalves, G. Macedo
Journal: Endoscopy (2022)

Aims To evaluate the accuracy of colonoscopy in localization of colorectal malignancy, predictive factors of concordance with intra-operative localization and surgical sequelae of an incorrect localization.
COVID-19 vaccines elicit robust cellular immunity and clinical protection in chronic lymphocytic leukemia
Authors: Helen Parry, Rachel Bruton, Thomas Roberts, Graham McIlroy, Sarah Damery, Panagiota Sylla, Alexander C. Dowell, Gokhan Tut, Tara Lancaster, David Bone, Brian Willett, Nicola Logan, Sam Scott, Sam Hulme, Azar Jadir, Umayr Amin, Sam Nicol, Christine Stephens, Sian Faustini, Saly Al-Taei, Alex Richter, Daniel Blakeway, Kriti Verma, Sandra Margielewska-Davies, Hayden Pearce, Guy Pratt, Jianmin Zuo, Shankara Paneesha, Paul Moss
Journal: Cancer Cell (2022)
LATERALLY SPREADING TUMOR EXTENDING TO THE DENTATE LINE: CHALLENGES OF ENDOSCOPIC SUBMUCOSAL DISSECTION (ESD)
Authors: J.I. Alves da Silva, D. Falcão, S. Archer, R. Marcos-Pinto, I. Pedroto, R. Küttner-Magalhães
Journal: Endoscopy (2022)

82-year-old male referred due to a 56mm nodular-mixed type laterally-spreading tumour, Paris 0-Is+IIa, JNET type-2B, located in the distal rectum, extending to the anal verge.
Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson’s disease
Authors: Tushar Kamath, Abdulraouf Abdulraouf, S. J. Burris, Jonah Langlieb, Vahid Gazestani, Naeem M. Nadaf, Karol Balderrama, Charles Vanderburg, Evan Z. Macosko
Journal: Nature Neuroscience (2022)

Abstract The loss of dopamine (DA) neurons within the substantia nigra pars compacta (SNpc) is a defining pathological hallmark of Parkinson’s disease (PD). Nevertheless, the molecular features associated with DA neuron vulnerability have not yet been fully identified. Here, we developed a protocol to enrich and transcriptionally profile DA neurons from patients with PD and matched controls, sampling a total of 387,483 nuclei, including 22,048 DA neuron profiles. We identified ten populations and spatially localized each within the SNpc using Slide-seq. A single subtype, marked by the expression of the gene AGTR1 and spatially confined to the ventral tier of SNpc, was highly susceptible to loss in PD and showed the strongest upregulation of targets of TP53 and NR2F2 , nominating molecular processes associated with degeneration. This same vulnerable population was specifically enriched for the heritable risk associated with PD, highlighting the importance of cell-intrinsic processes in determining the differential vulnerability of DA neurons to PD-associated degeneration.
PANCREATIC CYSTIC FLUID GLUCOSE LEVEL IN THE DIAGNOSIS OF MUCINOUS PANCREATIC CYSTS: A SINGLE CENTRE EXPERIENCE
Authors: S. Stigliano, F.M. Di Matteo
Journal: Endoscopy (2022)

Aims Available intra-cystic biomarkers have low accuracy in distinguishing pancreatic cystic neoplasm (PCN). Glucose is an attractive alternative due to its availability and low cost.
COMPREHENSIVE REVIEW OF PUBLICLY AVAILABLE COLONOSCOPIC IMAGING DATASETS FOR ARTIFICIAL INTELLIGENCE RESEARCH: AVAILABILITY, ACCESSIBILITY AND USABILITY
Authors: B.B. Houwen, K.J. Nass, J.L. Vleugels, P. Fockens, Y. Hazewinkel, E. Dekker
Journal: Endoscopy (2022)

Aims Publicly available datasets containing colonoscopic imaging data are valuable resources for artificial intelligence (AI)-research in gastrointestinal endoscopy. This review aimed to describe the availability, accessibility and usability of these publicly available colonoscopic imaging datasets.
Efficacy and Safety of Dapagliflozin in Type 2 Diabetes According to Baseline Blood Pressure: Observations From DECLARE-TIMI 58 Trial
Authors: Remo H.M. Furtado, Itamar Raz, Erica L. Goodrich, Sabina A. Murphy, Deepak L. Bhatt, Lawrence A. Leiter, Darren K. McGuire, John P.H. Wilding, Philip Aylward, Anthony J Dalby, Mikael Dellborg, Doina Dimulescu, José C. Nicolau, Anthonius J.M. Oude Ophuis, Avivit Cahn, Ofri Mosenzon, Ingrid Gause-Nilsson, Anna Maria Langkilde, Marc S. Sabatine, Stephen D. Wiviott
Journal: Circulation (2022)

Dapagliflozin improved heart failure and kidney outcomes in patients with type 2 diabetes (T2DM) with or at high risk for atherosclerotic cardiovascular disease in the DECLARE-TIMI 58 trial (Dapagliflozin Effect on Cardiovascular Events - Thrombolysis in Myocardial Infarction 58). Here, the aim was to analyze the efficacy and safety of dapagliflozin stratified according to baseline systolic blood pressure (SBP).The DECLARE-TIMI 58 trial randomly assigned patients with T2DM and either previous atherosclerotic cardiovascular disease or atherosclerotic cardiovascular disease risk factors to dapagliflozin or placebo. Patients were categorized by baseline SBP levels: <120, 120 to 129, 130 to 139, 140 to 159, and ≥160 mm Hg (normal, elevated, stage 1, stage 2, and severe hypertension, respectively). Efficacy outcomes of interest were hospitalization for heart failure and a renal-specific composite outcome (sustained decrease in estimated glomerular filtration rate by 40%, progression to end-stage renal disease, or renal death). Safety outcomes included symptoms of volume depletion, lower extremity amputations, and acute kidney injury.The trial comprised 17 160 patients; mean age, 64.0±6.8 years; 37.4% women; median duration of T2DM, 11 years; 40.6% with prevalent cardiovascular disease. Overall, dapagliflozin reduced SBP by 2.4 mm Hg (95% CI, 1.9-2.9; P<0.0001) compared with placebo at 48 months. The beneficial effects of dapagliflozin on hospitalization for heart failure and renal outcomes were consistent across all baseline SBP categories, with no evidence of modification of treatment effect (Pinteractions=0.28 and 0.52, respectively). Among normotensive patients, the hazard ratios were 0.66 (95% CI, 0.42-1.05) and 0.39 (95% CI, 0.19-0.78), respectively, for hospitalization for heart failure and the renal-specific outcome. Events of volume depletion, amputation, and acute kidney injury did not differ with dapagliflozin overall or within any baseline SBP group.In patients with T2DM with or at high atherosclerotic cardiovascular disease risk, dapagliflozin reduced risk for hospitalization for heart failure and renal outcomes regardless of baseline SBP, with no difference in adverse events of interest at any level of baseline SBP. These results indicate that dapagliflozin provides cardiorenal benefits in patients with T2DM at high atherosclerotic cardiovascular disease risk independent of baseline blood pressure.URL: https://www.gov; Unique identifier: NCT01730534.
Correction: COVID-19 vaccination in Sindh Province, Pakistan: A modelling study of health impact and cost-effectiveness
Authors: Carl A. B Pearson, Fiammetta Bozzani, Simon R. Procter, Nicholas G. Davies, Maryam Huda, Henning Tarp Jensen, Marcus Keogh-Brown, Muhammad Khalid, Sedona Sweeney, Sergio Torres-Rueda, Rosalind M. Eggo, Anna Vassall, Mark Jit
Journal: PLoS Medicine (2022)

[This corrects the article DOI: 10.1371/journal.pmed.1003815.].
West Nile Virus and Other Domestic Nationally Notifiable Arboviral Diseases — United States, 2020
Authors: Raymond A. Soto, Matthew L. Hughes, J. Erin Staples, Nicole P. Lindsey
Journal: MMWR Morbidity and Mortality Weekly Report (2022)

Arthropod-borne viruses (arboviruses) are transmitted to humans primarily through the bite of infected mosquitoes and ticks. West Nile virus (WNV), mainly transmitted by Culex species mosquitos, is the leading cause of domestically acquired arboviral disease in the United States (1). Other arboviruses cause sporadic cases of disease and occasional outbreaks. This report summarizes passive data for nationally notifiable domestic arboviruses in the United States reported to CDC for 2020. Forty-four states reported 884 cases of domestic arboviral disease, including those caused by West Nile (731), La Crosse (88), Powassan (21), St. Louis encephalitis (16), eastern equine encephalitis (13), Jamestown Canyon (13), and unspecified California serogroup (2) viruses. A total of 559 cases of neuroinvasive WNV disease were reported, for a national incidence of 0.17 cases per 100,000 population. Because arboviral diseases continue to cause serious illness and the locations of outbreaks vary annually, health care providers should consider arboviral infections in patients with aseptic meningitis or encephalitis that occur during periods when ticks and mosquitoes are active, perform recommended diagnostic testing, and promptly report cases to public health authorities to guide prevention strategies and messaging.
OVERLAP SYNDROME OF JUVENILE POLYPOSIS SYNDROME AND HEREDITARY HEMORRHAGIC TELANGIECTASIA. TWO DISEASES ONE MUTATION
Authors: L.E. Zamora-Nava, X. Sanchez-Chavez, G. Grajales-Figueroa, A. Saul-Perez, M.A. Ramirez-Luna
Journal: Endoscopy (2022)

A 49 yo woman, with history of Osler Weber Rendu syndrome underwent total colectomy due to lower GI bleeding secondary to polypoid lesions, histopathology reported Juvenile Polyposis Syndrome. Videocapsule endoscopy showed vascular lesions and polyps in the proximal jejunum. Anterograde double-balloon enteroscopy was performed, angiectasias were treated with APC and three hamartomatous lesions were resected succesfully.
Nirsevimab: a promising therapy for RSV
Authors: Priya Venkatesan
Journal: The Lancet Microbe (2022)

Respiratory syncytial virus (RSV) causes a high burden of disease throughout the world, particularly in children, older people, and high-risk adults. The virus is one of the most prevalent causes of severe acute lower respiratory tract infections (LRTI), and the leading cause worldwide of infants being admitted to hospital. One study estimated that children younger than 5 years infected with RSV accounted for 33·1 million cases (uncertainty range 21·6–50·3) of acute LRTI, 3·2 million hospital admissions (2·7–3·8), and 59 600 in-hospital deaths (48 000–74 500) in 2015.
GOOD FOR THE ENVIRONMENT AND THE POCKET– AN AUDIT OF WASTE GENERATION AND RECYCLING PRACTICES WITHIN AN IRISH ENDOSCOPY UNIT
Authors: N. O'Morain, E. Joy, E. Donohoe, J. Doherty, R. Stack, H. Mulcahy, E. McDermott
Journal: Endoscopy (2022)

Aims Ireland has one of the highest greenhouse gas emissions per capita in the EU, at 13.3 metric tons of CO2 equivalent/person. Healthcare accounts for 30% of all public sector greenhouse gas emissions. General waste accounts for almost 60% of waste generated in Irish hospitals. It has been estimated that 1/3 of this could be recycled. A large volume of recyclable waste is generated in Endoscopy, however sustainable practices are not currently promoted. This quality improvement project sought to determine the volume of recyclable waste generated within Endoscopy and whether use of green bin would be a cost-effective strategy.
GASTRIC PERORAL ENDOSCOPIC MYOTOMY (GPOEM) VERSUS BOTULINIUM TOXIN INJECTION (BTI) FOR THE TREATMENT OF REFRACTORY GASTROPARESIS: FIRST DOUBLE-BLIND RANDOMIZED CONTROLLED STUDY
Authors: J.-M. Gonzalez, M. Picohe, V. Garbay, F. Mion, M. Barthet, V. Vitton
Journal: Endoscopy (2022)

Aims This is the first randomized study comparing the clinical efficacy of GPOEM with pyloric BTI in refractory gastroparesis. The aims were to compare the 3-month and 1 year efficacy (GCSI score), GES evolution, adverse events, quality of life (GIQLI and SF-12). Predictive factors were analyzed.
74P Management of early-stage hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) breast cancer in a real-word setting in Germany: A patient perspective
Authors: C. Jackisch, M. Banys-Paluchowski, A. Korfel, C. Stoffregen, T. Otto, J. Brown, I. Sanderson, A. Rider, D.I. Lüftner
Journal: Annals of Oncology (2022)
Longitudinal Changes in Hearing and Visual Impairments and Risk of Dementia in Older Adults in the United States
Authors: Phillip H. Hwang, W. T. Longstreth, Stephen M. Thielke, Courtney E. Francis, Marco Carone, Lewis H. Kuller, Annette L. Fitzpatrick
Journal: JAMA Network Open (2022)

Hearing and vision problems are individually associated with increased dementia risk, but the impact of having concurrent hearing and vision deficits, ie, dual sensory impairment (DSI), on risk of dementia, including its major subtypes Alzheimer disease (AD) and vascular dementia (VaD), is not well known.To evaluate whether DSI is associated with incident dementia in older adults.This prospective cohort study from the Cardiovascular Health Study (CHS) was conducted between 1992 and 1999, with as many as 8 years of follow-up. The multicenter, population-based sample was recruited from Medicare eligibility files in 4 US communities with academic medical centers. Of 5888 participants aged 65 years and older in CHS, 3602 underwent cranial magnetic resonance imaging and completed the modified Mini-Mental State Examination in 1992 to 1994 as part of the CHS Cognition Study. A total of 227 participants were excluded due to prevalent dementia, leaving a total of 3375 participants without dementia at study baseline. The study hypothesis was that DSI would be associated with increased risk of dementia compared with no sensory impairment. The association between the duration of DSI with risk of dementia was also evaluated. Data analysis was conducted from November 2019 to February 2020.Hearing and vision impairments were collected via self-report at baseline and as many as 5 follow-up visits.All-cause dementia, AD, and VaD, classified by a multidisciplinary committee using standardized criteria.A total of 2927 participants with information on hearing and vision at all available study visits were included in the analysis (mean [SD] age, 74.6 [4.8] years; 1704 [58.2%] women; 455 [15.5%] African American or Black; 2472 [85.5%] White). Compared with no sensory impairment, DSI was associated with increased risk of all-cause dementia (hazard ratio [HR], 2.60; 95% CI, 1.66-2.06; P < .001), AD (HR, 3.67; 95% CI, 2.04-6.60; P < .001) but not VaD (HR, 2.03; 95% CI, 1.00-4.09; P = .05).In this cohort study, DSI was associated with increased risk of dementia, particularly AD. Evaluation of hearing and vision in older adults may help to identify those at high risk of developing dementia.
1 LITER PEG+ASC BOWEL PREPARATION NER1006 IS AN INDEPENDENT PREDICTOR OF ADEQUATE AND HIGH-QUALITY CLEANSING SUCCESS: A POOLED ANALYSIS OF 2 RANDOMIZED PHASE 3 TRIALS
Authors: M. Epstein, E. Shah, C. Allen, R. Bisschops
Journal: Endoscopy (2022)

Aims Adequacy of bowel preparation for colonoscopy is critical for maximizing the therapeutic benefits of colonoscopy. High-quality cleansing has been shown to improve adenoma detection rates for individual patients. This analysis aimed to use optimized regression models to elucidate predictors of both adequate and high-quality colon cleansing success.
RISK FACTORS FOR NON-CURATIVE ENDOSCOPIC RESECTION OF EARLY GASTRIC CANCER
Authors: H. Uchima, D. Libânio, R. Ortigão, M. Carrasco, L.P. Afonso, P. Pimentel-Nunes, M. Dinis-Ribeiro
Journal: Endoscopy (2022)

Aims Early gastric cancer (EGC) is defined as adenocarcinoma that invades no more deeply than the submucosa irrespective of lymph node metastasis (LNM). In selected cases of EGC with very low risk of LNM endoscopic submucosal dissection (ESD) can be curative. However, in 20% of cases there are pathological features other than the standard and expanded criteria that may lead to non-curative resection (NCR).
DYSPLASTIC BARRETT’S OESOPHAGUS (DBO): REAL WORLD DATA REGARDING LONG TERM FOLLOW-UP
Authors: G. Axiaris, A. Ioannou, E. Papathanasiou, M. Tzakri, G. Leonidakis, E. Zampeli, P. Baxevanis, S. Michopoulos
Journal: Endoscopy (2022)

Methods Single center prospective analysis of DBO patients’ data (demographic, endoscopic and histologic) with at least a 6 month follow up and the endoscopic interventions applied: endoscopic mucosal resection (EMR), argon plasma coagulation (APC), radiofrequency ablation (RFA).
RECURRENT METASTATIC UROTHELIAL CANCER PRESENTING WITH DUODENAL OBSTRUCTION MANAGED SUCCESSFULLY WITH ENDOSCOPIC STENTING AND STENT DILATATION
Authors: K. Mushtaq, M.U. Khan, M.A. Hassan, A. Abdelmola, R. Yakoob
Journal: Endoscopy (2022)

Aims Urothelial cancers can rarely metastasize to the duodenum and can present with duodenal obstruction as the main presentation. Duodenal obstruction due to urothelial cancer can be managed either by surgery or luminal stenting. we present a case where the duodenal obstruction was managed successfully by endoscopic luminal stenting.
EFFICACY AND SAFETY OF A 1-LITRE LOW VOLUME PREP IN A BOWEL CANCER SCREENING COHORT
Authors: A. Gandhi, L. Cramb, K.-A. Condren, R. Moore, B. Bentley, K. Dunn, S. John
Journal: Endoscopy (2022)

Aims Adequacy of bowel prep is essential for high quality colonoscopy, for early detection of neoplasia and to reduce adenoma missed rates. Standard prep regimes are difficult to tolerate and patient compliance is poor. A novel low volume (1L) bowel prep with macrogol 3350, Sodium Ascorbate, Ascorbic acid and electrolytes is now available. We aimed to assess its efficacy and safety.
STENTFIX OTSC​ FOR PREVENTING FULLY COVERED SELF-EXPANDABLE METAL STENTS MIGRATION IN THE GASTROINTESTINAL TRACT
Authors: C. Elmo, R. Manta, M. Conio, A. Zullo
Journal: Endoscopy (2022)

Methods 31 consecutive patients (median age: 58 years; males, 80%), with diseases of different etiology and localization (upper or lower GI tract) were enrolled. For each patient, OTSC device was placed to prevent FCSEMS migration. All patients received longitudinal follow-up.