tbuckley/cabot-search huggingface dataset:
TRIB3 reduces CD8 <sup>+</sup> T cell infiltration and induces immune evasion by repressing the STAT1-CXCL10 axis in colorectal cancer
Authors: Shuang Shang, Yu-wei Yang, Fei Chen, Liang Yu, Shuo-hao Shen, Ke Li, Bing Cui, Xiao-Xi Lv, Cheng Zhang, Chen Yang, Jing Liu, Jiao-jiao Yu, Xiao-wei Zhang, Ping-ping Li, Sheng-tao Zhu, Hai-zeng Zhang, Fang Hua
Journal: Science Translational Medicine (2022)

High CD8+ T cell infiltration in colorectal cancer (CRC) should suggest a favorable prognosis and a satisfactory response to immunotherapy; however, the vast majority of patients with CRC do not benefit from immunotherapy due to poor T cell infiltration. Therefore, a better understanding of the mechanisms for T cell exclusion from CRC tumors is needed. Tribbles homolog 3 (TRIB3) has been implicated as an oncoprotein, but its role in regulating antitumor immune responses has not been defined. Here, we demonstrated that TRIB3 inhibits CD8+ T cell infiltration in various CRC mouse models. We showed that TRIB3 was acetylated by acetyltransferase P300, which inhibited ubiquitination and subsequent proteasomal degradation of TRIB3. Ectopically expressed TRIB3 inhibited signal transducer and activator of transcription 1 (STAT1) activation and STAT1-mediated CXCL10 transcription by enhancing the epidermal growth factor receptor signaling pathway, causing a reduction in tumor-infiltrating T cells. Genetic ablation of Trib3 or pharmacological acceleration of TRIB3 degradation with a P300 inhibitor increased T cell recruitment and sensitized CRCs to immune checkpoint blockade therapy. These findings identified TRIB3 as a negative modulator of CD8+ T cell infiltration in CRCs, highlighting a potential therapeutic target for treating immunologically “cold” CRCs.
Sleep and circadian rhythms in Parkinson’s disease and preclinical models
Authors: Jeremy Hunt, Elizabeth J. Coulson, Rajendram Rajnarayanan, Henrik Oster, Aleksandar Videnovic, Oliver Rawashdeh
Journal: Molecular Neurodegeneration (2022)

The use of animals as models of human physiology is, and has been for many years, an indispensable tool for understanding the mechanisms of human disease. In Parkinson's disease, various mouse models form the cornerstone of these investigations. Early models were developed to reflect the traditional histological features and motor symptoms of Parkinson's disease. However, it is important that models accurately encompass important facets of the disease to allow for comprehensive mechanistic understanding and translational significance. Circadian rhythm and sleep issues are tightly correlated to Parkinson's disease, and often arise prior to the presentation of typical motor deficits. It is essential that models used to understand Parkinson's disease reflect these dysfunctions in circadian rhythms and sleep, both to facilitate investigations into mechanistic interplay between sleep and disease, and to assist in the development of circadian rhythm-facing therapeutic treatments. This review describes the extent to which various genetically- and neurotoxically-induced murine models of Parkinson's reflect the sleep and circadian abnormalities of Parkinson's disease observed in the clinic.
Association of the Implementation of Child Tax Credit Advance Payments With Food Insufficiency in US Households
Authors: Paul R. Shafer, Katherine M. Gutiérrez, Stephanie Ettinger de Cuba, Allison Bovell-Ammon, Julia Raifman
Journal: JAMA Network Open (2022)

<h3>Importance</h3> A key component of the American Rescue Plan Act of 2021 included an expansion of the Child Tax Credit with advance payments beginning in July 2021, a “child allowance” that was projected to dramatically reduce child poverty. Food insufficiency has increased markedly during the economic crisis spurred by the COVID-19 pandemic, with disparities among marginalized populations, and may be associated with substantial health care and social costs. <h3>Objective</h3> To assess whether the introduction of advance payments for the Child Tax Credit in mid-July 2021 was associated with changes in food insufficiency in US households with children. <h3>Design, Setting, and Participants</h3> This cross-sectional study used data from several phases of the Household Pulse Survey, conducted by the US Census Bureau from January 6 to August 2, 2021. The survey had 585 170 responses, representing a weighted population size of 77 165 153 households. <h3>Exposure</h3> The first advance Child Tax Credit payment, received on July 15, 2021. <h3>Main Outcomes and Measures</h3> Household food insufficiency. <h3>Results</h3> The weighted sample of 585 170 respondents was mostly female (51.5%) and non-Hispanic White (62.5%), with a plurality aged 25 to 44 years (48.1%), having a 4-year degree or more (34.7%) and a 2019 household income of $75 000 to $149 999 (23.1%). In the weeks after the first advance payment of the Child Tax Credit was made (July 21 to August 2, 2021), 62.4% of households with children reported receiving it compared with 1.1% of households without children present (<i>P</i> &lt; .001). There was a 3.7–percentage point reduction (95% CI, –0.055 to –0.019 percentage points;<i>P</i> &lt; .001) in household food insufficiency for households with children present in the survey wave after the first advance payment of the Child Tax Credit, corresponding to a 25.9% reduction, using an event study specification. Difference-in-differences (−16.4%) and modified Poisson (−20.8%) models also yielded large estimates for reductions in household food insufficiency associated with the first advance payment of the expanded Child Tax Credit. <h3>Conclusions and Relevance</h3> This study suggests that the Child Tax Credit advance payment increased household income and may have acted as a buffer against food insufficiency. However, its expansion and advance payment are only a temporary measure for 2021. Congress must consider whether to extend these changes or make them permanent and improve implementation to reduce barriers to receipt for low-income families.
Staging Cardiac Damage in Patients With Asymptomatic Aortic Valve Stenosis
Authors: Lionel Tastet, Christophe Tribouilloy, Sylvestre Maréchaux, E. Mara Vollema, Victoria Delgado, Erwan Salaun, Mylène Shen, Romain Capoulade, Marie-Annick Clavel, Marie Arsenault, Élisabeth Bédard, Mathieu Bernier, Jonathan Beaudoin, Jagat Narula, Patrizio Lancellotti, Jeroen J. Bax, Philippe Généreux, Philippe Pibarot
Journal: Journal of the American College of Cardiology (2019)
Bacterial biofilms predominate in both acute and chronic human lung infections
Authors: Mette Kolpen, Kasper Nørskov Kragh, Juan Barraza Enciso, Daniel Faurholt-Jepsen, Birgitte Lindegaard, Gertrud Baunbæk Egelund, Andreas Vestergaard Jensen, Pernille Ravn, Inger Hee Mabuza Mathiesen, Alexandra Gabriella Gheorge, Frederik Boëtius Hertz, Tavs Qvist, Marvin Whiteley, Peter Østrup Jensen, Thomas Bjarnsholt
Journal: Thorax (2022)

Background A basic paradigm of human infection is that acute bacterial disease is caused by fast growing planktonic bacteria while chronic infections are caused by slow-growing, aggregated bacteria, a phenomenon known as a biofilm. For lung infections, this paradigm has been thought to be supported by observations of how bacteria proliferate in well-established growth media in the laboratory—the gold standard of microbiology. Objective To investigate the bacterial architecture in sputum from patients with acute and chronic lung infections. Methods Advanced imaging technology was used for quantification and direct comparison of infection types on fresh sputum samples, thereby directly testing the acute versus chronic paradigm. Results In this study, we compared the bacterial lifestyle (planktonic or biofilm), growth rate and inflammatory response of bacteria in freshly collected sputum (n=43) from patient groups presenting with acute or chronic lung infections. We found that both acute and chronic lung infections are dominated by biofilms (aggregates of bacteria within an extracellular matrix), although planktonic cells were observed in both sample types. Bacteria grew faster in sputum from acute infections, but these fast-growing bacteria were enriched in biofilms similar to the architecture thought to be reserved for chronic infections. Cellular inflammation in the lungs was also similar across patient groups, but systemic inflammatory markers were only elevated in acute infections. Conclusions Our findings indicate that the current paradigm of equating planktonic with acute and biofilm with chronic infection needs to be revisited as the difference lies primarily in metabolic rates, not bacterial architecture.
Bone Cancer
Authors: J Sybil Biermann, Douglas R Adkins, Mark Agulnik, Robert S Benjamin, Brian Brigman, James E Butrynski, David Cheong, Warren Chow, William T Curry, Deborah A Frassica, Frank J Frassica, Kenneth R Hande, Francis J Hornicek, Robin L Jones, Joel Mayerson, Sean V McGarry, Brian McGrath, Carol D Morris, Richard J O'Donnell, R Lor Randall, Victor M Santana, Robert L Satcher, Herrick J Siegel, Margaret von Mehren, Mary Anne Bergman, Hema Sundar
Journal: Journal of the National Comprehensive Cancer Network (2013)

Primary bone cancers are extremely rare neoplasms, accounting for fewer than 0.2% of all cancers. The evaluation and treatment of patients with bone cancers requires a multidisciplinary team of physicians, including musculoskeletal, medical, and radiation oncologists, and surgeons and radiologists with demonstrated expertise in the management of these tumors. Long-term surveillance and follow-up are necessary for the management of treatment late effects related to surgery, radiation therapy, and chemotherapy. These guidelines discuss the management of chordoma, giant cell tumor of the bone, and osteosarcoma.
Regional right ventricular strain rate imaging following a senning repair. How do ultrasound based regional function indices compare with global ejection fraction assessed by magnet resonance imaging? Frank Weidemann, Benedicte Eyskens, Fadi Jamal, Luc Mertens, Marc Gewillig, Bart Bijnens, Liv Hatle, George R. Sutherland. Cardiology Department, University Hospital Gasthuisberg, Leuven, Belgium
Journal: Journal of the American College of Cardiology (2001)
The practice of medicine
Authors: Richard C. Rose
Journal: JAMA (1989)

<h3>To the Editor. —</h3> The defense by Dr Dandoy<sup>1</sup>of her public health practice was stirring and, I suspect, accurate. I fear, however, she might have misunderstood the question: "Have you ever<i>practiced</i>medicine?" I suspect that when that question is asked the real questions are: "Have you ever experienced the frustrations of standing beside the bed of a dying patient knowing there is nothing more you can do?" "Have you had to tell the family of a patient that their loved one has just died?" "Do you drag yourself to the hospital in the middle of the night to provide emergency care to a patient you have never seen who presents with a critical illness?" "Have you been told by Blue Cross/Blue Shield that all of the above activities are unnecessary and unreasonable and that they have no intention of reimbursing you for them?" and "Have you become
Error in Author Affiliations
Authors: Krista Huybrechts, Sonia Hernández-Díaz, Brian Bateman
Journal: JAMA Pediatrics (2021)

Initial safety signals for ondansetron are related to a potential increased risk of oral clefts and cardiovascular defects.These initial safety signals were further investigated in controlled observational studies, which formed the basis for the European Medicines Agency's recommendation that we discussed in our Viewpoint. 5At this point in the evidencegenerating process, uncontrolled estimates based on spontaneous reports will not, unfortunately, aid pregnant individuals and their clinicians who need to make complex treatment decisions in the context of uncertainty.
DOMESTIC CORRESPONDENCE.
Authors: John H. Gaines
Journal: JAMA (1891)

Hot Springs, Ark., Nov. 10, 1891. <h3>Editor The Journal, Chicago, Ill.:</h3> Desirous of calling the attention of the medical profession to the anomalous condition of things existing at this place, I ask the publication inThe Journalof such facts as are given herewith: This town is sustained<i>entirely</i>by visitors coming here in search of health or pleasure, mostly the former. There is literally nothing else. The facility with which the invalid can be gulled on his arrival here is startlingly wonderful, and opens a very fine field for sharpers, who are nominally in the profession, aided by ropers who meet the victims on the railroad trains and beguile them first to a boarding house and bath house, and finally to the doctor's office to be robbed and maltreated. This evil has assumed such outrageous proportions, that the few practitioners here who take the code for their guide, are
Quantitative assessment of left ventricular contractile synchrony during biventricular pacing using color kinesis echocardiography Carlo Pappone, Salvatore Rosanio, Monica Tocchi, Eustachio Agricola, Gabriele Vicedomini, Adriano Salvati, Simone Gulletta, Patrizio Mazzone, Giovanni La Canna. San Raffaele University Hospital, Milan, Italy
Journal: Journal of the American College of Cardiology (2001)
Preliminary Clinical Description of Severe Acute Respiratory Syndrome
Journal: JAMA (2003)

Severe acute respiratory syndrome (SARS) is a condition of unknown etiology that has been described in patients in Asia, North America, and Europe. This report summarizes the clinical description of patients with SARS based on information collected since mid-February 2003 by the World Health Organization (WHO), Health Canada, and CDC in collaboration with health authorities and clinicians in Hong Kong, Taiwan, Bangkok, Singapore, the United Kingdom, Slovenia, Canada, and the United States. This information is preliminary and limited by the broad and necessarily nonspecific case definition.
Mechanism of lumen enlargement during cutting balloon angioplasty for in-stent restenosis: An intravascular ultrasound study Javed M. Ahmed, Gary S. Mintz, Marco Castagna, Neil J. Weissman, Lowell F. Satler, Kenneth M. Kent, Augusto D. Pichard. Washington Hospital Center, Washington, DC
Journal: Journal of the American College of Cardiology (2001)
Patients with Rare Cancers in the Drug Rediscovery Protocol (DRUP) Benefit from Genomics-Guided Treatment
Authors: Louisa R. Hoes, Jade M. van Berge Henegouwen, Hanneke van der Wijngaart, Laurien J. Zeverijn, Daphne L. van der Velden, Joris van de Haar, Paul Roepman, Wendy J. de Leng, Anne M.L. Jansen, Erik van Werkhoven, Vincent van der Noort, Alwin D.R. Huitema, Eelke H. Gort, Jan Willem B. de Groot, Emile D. Kerver, Derk Jan de Groot, Frans Erdkamp, Laurens V. Beerepoot, Mathijs P. Hendriks, Egbert F. Smit, Winette T.A. van der Graaf, Carla M.L. van Herpen, Mariette Labots, Ann Hoeben, Hans Morreau, Martijn P. Lolkema, Edwin Cuppen, Hans Gelderblom, Henk M.W. Verheul, Emile E. Voest
Journal: Clinical Cancer Research (2022)

Abstract Purpose: Patients with rare cancers (incidence less than 6 cases per 100,000 persons per year) commonly have less treatment opportunities and are understudied at the level of genomic targets. We hypothesized that patients with rare cancer benefit from approved anticancer drugs outside their label similar to common cancers. Experimental Design: In the Drug Rediscovery Protocol (DRUP), patients with therapy-refractory metastatic cancers harboring an actionable molecular profile are matched to FDA/European Medicines Agency–approved targeted therapy or immunotherapy. Patients are enrolled in parallel cohorts based on the histologic tumor type, molecular profile and study drug. Primary endpoint is clinical benefit (complete response, partial response, stable disease ≥ 16 weeks). Results: Of 1,145 submitted cases, 500 patients, including 164 patients with rare cancers, started one of the 25 available drugs and were evaluable for treatment outcome. The overall clinical benefit rate was 33% in both the rare cancer and nonrare cancer subgroup. Inactivating alterations of CDKN2A and activating BRAF aberrations were overrepresented in patients with rare cancer compared with nonrare cancers, resulting in more matches to CDK4/6 inhibitors (14% vs. 4%; P ≤ 0.001) or BRAF inhibitors (9% vs. 1%; P ≤ 0.001). Patients with rare cancer treated with small-molecule inhibitors targeting BRAF experienced higher rates of clinical benefit (75%) than the nonrare cancer subgroup. Conclusions: Comprehensive molecular testing in patients with rare cancers may identify treatment opportunities and clinical benefit similar to patients with common cancers. Our findings highlight the importance of access to broad molecular diagnostics to ensure equal treatment opportunities for all patients with cancer.
SURGERY.
Journal: JAMA (1885)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Liquid biopsy in gliomas: A RANO review and proposals for clinical applications
Authors: Riccardo Soffietti, Chetan Bettegowda, Ingo K Mellinghoff, Katherine E Warren, Manmeet S Ahluwalia, John F De Groot, Evanthia Galanis, Mark R Gilbert, Kurt A Jaeckle, Emilie Le Rhun, Roberta Rudà, Joan Seoane, Niklas Thon, Yoshie Umemura, Michael Weller, Martin J van den Bent, Michael A Vogelbaum, Susan M Chang, Patrick Y Wen
Journal: Neuro-Oncology (2022)

There is an extensive literature highlighting the utility of blood-based liquid biopsies in several extracranial tumors for diagnosis and monitoring.The RANO (Response Assessment in Neuro-Oncology) group developed a multidisciplinary international Task Force to review the English literature on liquid biopsy in gliomas focusing on the most frequently used techniques, that is circulating tumor DNA, circulating tumor cells, and extracellular vesicles in blood and CSF.ctDNA has a higher sensitivity and capacity to represent the spatial and temporal heterogeneity in comparison to circulating tumor cells. Exosomes have the advantages to cross an intact blood-brain barrier and carry also RNA, miRNA, and proteins. Several clinical applications of liquid biopsies are suggested: to establish a diagnosis when tissue is not available, monitor the residual disease after surgery, distinguish progression from pseudoprogression, and predict the outcome.There is a need for standardization of biofluid collection, choice of an analyte, and detection strategies along with rigorous testing in future clinical trials to validate findings and enable entry into clinical practice.
Schizophrenia: The Cinderella of Psychiatry
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Plastic and Reconstructive Surgery
Authors: J. J. Longacre
Journal: JAMA (1971)

This opus magnum by Hans May presents in 1,255 pages the summation of the work of a master plastic surgeon who trained under the great Lexer of Munich. He had the good fortune to be his assistant and participate in his chief's scientific pioneering and to work with him closely in writing and teaching. It is from this that he gained the<i>Geist</i>. This thorough and exact approach is evident throughout the various chapters of the work, whether in those devoted to the general principles of wound healing, tissue handling, and shifting of tissue either by graft of flaps, or the section on cleft palate. The literature has been carefully culled, both past and present, giving each pioneer his rightful place in the development of the various phases of plastic and reconstructive surgery. He presents in considerable depth and in a clear fashion (that the trainee and practitioner can understand)
Acute onset of cyanosis induces diastolic dysfunction in immature lambs Anirban Banerjee, Karug Gunasegaran, Santhinidevi Ramasamy, Sameh M. Arebi, Patrick O'Brien, Jonathan Rhodes, Natesa G. Pandian, Kenneth G. Warner. Tuffs-New England Medical Center, Boston, MA
Journal: Journal of the American College of Cardiology (2001)