tbuckley/cabot-search huggingface dataset:
Positive FAPI PET/CT in a Bilateral Mammary Angiosarcoma Patient With Less Impressive FDG PET/CT Images
Authors: Siwen Qiu, Sijuan Zou, Siyuan Cheng, Shuang Song, Xiaohua Zhu
Journal: Clinical Nuclear Medicine (2022)

Bilateral primary angiosarcoma of the breast is an extremely rare disease. We describe a case with bilateral angiosarcoma of the breast well visualized on 68Ga-FAPI PET/CT in a 30-year-old woman with a history of right breast-conserving surgery. However, the lesions are less impressive on 18F-FDG PET/CT. No additional findings including lymph node and distant metastases were noted. The patient underwent bilateral mastectomy, and histopathology revealed well-differentiated angiosarcoma that involved bilateral breast parenchyma and the left nipple. Our case illustrates that 68Ga-FAPI PET/CT can be more sensitive in detecting well-differentiated angiosarcoma of the breast.
Book Listings
Journal: Annals of Internal Medicine (2001)

Book Listings1 May 2001Book ListingsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-9_Part_1-200105010-00001 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Alternative MedicineAcupuncture: Efficacy, Safety and PracticeBritish Medical Association. 131 pages. Newark, NJ: Gordon and Breach/Harwood Academic; 2000. $24.00. ISBN 905823164X. Order phone 800-545-8398.Fundamentals of Complementary and Alternative Medicine2nd edition. MS Micozzi, ed. 464 pages. Philadelphia: WB Saunders; 2001. $49.00. ISBN 0443065764. Order phone 215-238-7800.Handbook of Religion and HealthHG Koenig, ME McCullough, and DB Larson. 712 pages. New York: Oxford Univ Pr; 2001. $65.00. ISBN 0195118669. Order phone 800-451-7556.Integrative Health Care: Complementary and Alternative Therapies for the Whole PersonVS Sierpina, ed. 396 pages. Philadelphia: FA Davis; 2001. $30.00. ISBN 0803607040. Order phone 800-323-3555.CardiologyAtherosclerosis: Gene Expression, ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 2001Volume 134, Issue 9_Part_1Page: B1KeywordsBurnsComputed axial tomography ePublished: 1 May 2001 Issue Published: 1 May 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Myocarditis
Authors: Gabriel Fung, Honglin Luo, Ye Qiu, Decheng Yang, Bruce McManus
Journal: Circulation Research (2016)

Viral myocarditis remains a prominent infectious-inflammatory disease for patients throughout the lifespan. The condition presents several challenges including varied modes of clinical presentation, a range of timepoints when patients come to attention, a diversity of approaches to diagnosis, a spectrum of clinical courses, and unsettled perspectives on therapeutics in different patient settings and in the face of different viral pathogens. In this review, we examine current knowledge about viral heart disease and especially provide information on evolving understanding of mechanisms of disease and efforts by investigators to identify and evaluate potential therapeutic avenues for intervention.
PASTEURIZATION.
Authors: M. J. ROSENAU
Journal: JAMA (1907)

<h3>Director Hygiene Laboratory, U. S. P. H. and M.-H. S.</h3><h3>Advantages.</h3> —The advantage of pasteurization is that it is a cheap and effective means of preventing the transmission of infectious diseases such as tuberculosis, typhoid fever, diphtheria, scarlet fever, etc., commonly spread by milk. <h3>Disadvantages.</h3> —Pasteurization promotes carelessness on the farm and dairy, etc. (This may be controlled by proper regulations, inspections and laboratory examinations.) Pasteurization renders milk less digestible. (While it is generally conceded that boiled milk commonly induces constipation, the majority of the evidence plainly indicates that pasteurization has little, if any, effect on the digestibility of the milk.) Pasteurized milk favors the production of rickets and scurvy. (There is no proof to this effect and authorities agree that the danger is slight; and, further, that it may readily be obviated.) By destroying the non-spore-bearing bacteria, pasteurization sometimes allows toxic organisms to grow and produce serious poisons
Serum albumin
Authors: M A Rothschild, M Oratz, S S Schreiber
Journal: Hepatology (1988)

The liver manufactures albumin at a massive rate and decreases production in times of environmental, nutritional, toxic and trauma stress. Osmotic pressure is a basic evolutionary regulatory factor, and hormonal control over albumin production has been demonstrated. Where and why new or old albumin is degraded are questions which have not been clarified, although the vascular endothelium may well be the degradative site. Albumin is important as a transport protein, as a measure of evolution and as a model to study secretion following synthesis without the intervening steps of glycosylation. Investigations as to how this protein enters the endoplasmic membrane may well answer some of the questions concerning signal peptide insertion (288). The role of the urea cycle intermediate ornithine and its participation in polyamine synthesis, which has a positive effect on albumin synthesis, is under study. Likewise, the inverse relation between acute-phase protein synthesis and albumin synthesis regulated by interleukin 1 and other cytokines will merit further study. These are a few of the concepts which will be tested in the future.
Intestinal stem cell dynamics in homeostasis and cancer
Authors: Rana Ramadan, Milou S. van Driel, Louis Vermeulen, Sanne M. van Neerven
Journal: Trends in cancer (2022)

The relationship between intestinal stem cells (ISCs) and colorectal cancer (CRC) has been a topic of intense study. Uncovering stem cell dynamics in homeostasis and following acquisition of oncogenic mutations has provided unprecedented insights into CRC initiation, and it is increasingly evident that the microenvironment plays a key role in regulating stem cell fate and functionality. Consequently, imbalances in the signaling between the niche and ISCs perturb homeostasis and promote cancer development. Furthermore, stem cell-like cells drive growth and progression of established CRCs and these cells also critically rely on microenvironmental input. Here, we highlight the importance of stem cell/niche interactions in developing and established CRC and discuss how these can be modulated to develop novel preventive and therapeutic interventions.
Current Medical Literature.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Laxative abuse.
Authors: J H Cummings
Journal: Gut (1974)

Progress report Laxative abuseAmongst the patients of every gastroenterologist there is probably one, a woman, with a long history of abdominal discomfort and diarrhoea, perhaps with vomiting, weight loss, weakness, thirst, and a psychiatric illness.There may be a past history of an ill defined metabolic disorder or renal disease.Numerous investigations will have proved fruitless although a low serum potassium, a rather distensible, featureless colon on radiographs and non-specific inflammatory changes on rectal biopsy may not have been fully explained.The latest medication is of only temporary benefit and the notes become progressively thicker.This is the picture of a patient who is taking laxatives to excess and probably concealing the fact from her doctor.Abuse of laxatives to this extent is one end of a spectrum of laxative taking which is well entrenched in our culture.The association of a regular bowel habit with physical and spiritual well being has its origins in early history (katharsis from the Greek cleansing; purgo from the Latin to purify, to make clean) and continues today with immense annual sales1 2.3.Well over 200 preparations are available over the counter in chemists' shops4 with between 15 and 30 % of people aged over 60 taking more than one dose weekly5.In general these preparations are safe with few reports of their danger6"7 when taken in recommended doses.Oxyph'enisatin has proved to be an exception as it has been closely linked with the development of hepatitis and cirrhosis28' 9,10, particularly when given with dioctylsodium sulpho- succinate'1"12.Death due to laxatives is rare13'4,15 but the syndrome of chronic ill health, sometimes called, but not identical with, the cathartic colon16,17,18,19, and due to long-continued and often surreptitious over- indulgence in laxatives has been widely reported'5-51. Clinical FeaturesOver 90 % of patients suffering from this condition are women.They present most commonly with diarrhoea, weakness, abdominal pain, nausea, vomiting, and an associated psychiatric disorder.However, these presenting features may become blurred with the passing of time so that in addition there may be weight loss, abdominal distension, amenorrhoea, thirst, or oedema.A history of childhood constipation is often a significant feature33"46 and the patients are not infrequently nurses or associated with medicine in some way30'35.36.51.Although diarrhoea is the single most common complaint, they may report constipation and even go to great lengths to conceal both the diarrhoea and laxative taking from the physician37'50'51.Indeed consti- pation is often the starting point for their consumption of laxatives.However, patients who develop what the pathologist or radiologist calls a 'cathartic colon' from prolonged laxative ingestion for constipation but without these other clinical features should not be included in the syndrome of laxative abuse.The commonly associated psychiatric disorders include depression, 758on July 24, 2023 by guest.
The British Society of Gastroenterology
Authors: M Kizu, J Newman, P Cotton, D Chattopadhyay, M Greaney, T Irvin, D Jenkins, M Gassull, A Leeds, G Metz, J Dilawari, Brenda Slavin, L Blendis
Journal: Gut (1977)

University of Cambridge on 1 and 2 April 1977.On Friday morning a symposium on gastritis
Healthcare resource utilisation and medical costs for children with interstitial lung diseases (chILD) in Europe
Authors: Elias Seidl, Nicolaus Schwerk, Julia Carlens, Martin Wetzke, Steve Cunningham, Nagehan Emiralioğlu, Nural Kiper, Joanna Lange, Katarzyna Krenke, Nicola Ullmann, Dora Krikovszky, Phillen Maqhuzu, Charlotte A Griese, Larissa Schwarzkopf, Matthias Griese
Journal: Thorax (2022)

No data on healthcare utilisation and associated costs for the many rare entities of children's interstitial lung diseases (chILD) exist. This paper portrays healthcare utilisation structures among individuals with chILD, provides a pan-European estimate of a 3-month interval per-capita costs and delineates crucial cost drivers.Based on longitudinal healthcare resource utilisation pattern of 445 children included in the Kids Lung Register diagnosed with chILD across 10 European countries, we delineated direct medical and non-medical costs of care per 3-month interval. Country-specific utilisation patterns were assessed with a children-tailored modification of the validated FIMA questionnaire and valued by German unit costs. Costs of care and their drivers were subsequently identified via gamma-distributed generalised linear regression models.During the 3 months prior to inclusion into the registry (baseline), the rate of hospital admissions and inpatient days was high. Unadjusted direct medical per capita costs (€19 818) exceeded indirect (€1 907) and direct non-medical costs (€1 125) by far. Country-specific total costs ranged from €8 713 in Italy to €28 788 in Poland. Highest expenses were caused by the disease categories 'diffuse parenchymal lung disease (DPLD)-diffuse developmental disorders' (€45 536) and 'DPLD-unclear in the non-neonate' (€47 011). During a follow-up time of up to 5 years, direct medical costs dropped, whereas indirect costs and non-medical costs remained stable.This is the first prospective, longitudinal study analysing healthcare resource utilisation and costs for chILD across different European countries. Our results indicate that chILD is associated with high utilisation of healthcare services, placing a substantial economic burden on health systems.
Gastrointestinal γδ T cells reveal differentially expressed transcripts and enriched pathways during peanut oral immunotherapy
Authors: Wenming Zhang, Gopal Krishna Dhondalay, Taryn Audrey Liu, Abhinav Kaushik, Ramona Hoh, Shirley Kwok, Neeraja Kambham, Nielsen Q Fernandez‐Becker, Sandra Andorf, Manisha Desai, Stephen J. Galli, Scott D. Boyd, Kari C. Nadeau, Monali Manohar, Rosemarie H. DeKruyff, R. Sharon Chinthrajah
Journal: Allergy (2022)

Dr. Nadeau reports grants from National Institute of Allergy and Infectious Diseases (NIAID), National Heart, Lung, and Blood Institute (NHLBI), National Institute of Environmental Health Sciences (NIEHS), and Food Allergy Research & Education (FARE); stock options from IgGenix, Seed Health, ClostraBio, and ImmuneID; is Director of World Allergy Organization (WAO), Advisor at Cour Pharma, Consultant for Excellergy, Red tree ventures, Eli Lilly, and Phylaxis, Co-founder of Before Brands, Alladapt, Latitude, and IgGenix; and National Scientific Committee member at Immune Tolerance Network (ITN), and National Institutes of Health (NIH) clinical research centers, outside the submitted work; patents include, "Mixed allergen composition and methods for using the same", "Granulocyte-based methods for detecting and monitoring immune system disorders", "Methods and Assays for Detecting and Quantifying Pure Subpopulations of White Blood Cells in Immune System Disorders," and "Methods of isolating allergen-specific antibodies from humans and uses thereof"; Dr. Chinthrajah reports grants from NIAID, CoFAR, Aimmune, DBV Technologies, Astellas, Regeneron, Stanford Maternal and Child Health Research Institute (MCHRI), and FARE. She is an Advisory Board Member at Alladapt Therapeutics, Novartis, Genentech, Sanofi, Allergenis, and Nutricia; Dr. Galli reports grants from the NIH; Dr. Boyd has consulted for Regeneron, Sanofi and Novartis on topics unrelated to this study, owns shares in AbCellera, has patents awarded or submitted related to immunoglobulin gene and protein analysis, and reports grants from the NIH; Dr. Andorf reports grants from the NIH. Drs. Zhang, Dhondalay, Hoh, Liu, Kaushik, DeKruyff, Kambham, Fernandez-Becker, Manohar, Kwok, and Desai indicate no conflict of interest. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Heart Disease.
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Women and alcohol. A review
Authors: S. B. Blume
Journal: JAMA (1986)

SOCIETY'S strong disapproval of the woman who drinks alcohol is not of recent origin. In ancient Rome, the drinking of alcohol by women was strictly prohibited<sup>1</sup>and punishable by death. Centuries later, Kant attributed the sobriety of women of his time to their special place in society and their adherence to a higher standard.<sup>2</sup> Today's woman alcoholic is viewed as weak willed (as is her male counterpart), but, in addition, she is thought to be promiscuous and sexually aggressive, despite data that indicate quite the reverse. Recent studies indicate that women who are heavy or problem drinkers are more likely to be victims of the alcohol-related sexual aggression of others.<sup>3,4</sup> Much of what we know about alcoholism is based on studies of male alcoholics, but in recent years a special focus on the woman alcoholic has emerged. Several conferences have been convened to review the ongoing research
Management of herpes simplex infections of the skin
Authors: E. B. Smith
Journal: JAMA (1976)

MANY REMEDIES, folk, over-the-counter, and prescribed, are recommended for treatment of cold sores and fever blisters. This immediately suggests two possibilities: either everything is effective in the management of the troublesome skin lesions of herpes simplex infection, or no treatment is really very effective. A brief review of the course and pathogenesis of herpetic infections will explain why both of these possibilities may be true and will give insight into the problems confronting both patient and physician. There are two variants of herpes simplex virus that affect man—type 1, which is most commonly isolated from facial lesions, and type 2, which normally causes herpes infections of the genitalia. Other than the differences in location and the earlier appearance of clinical and serological evidence of infection with herpesvirus type 1, the course of the disease caused by the two variants is quite similar. Most persons contract infection with herpesvirus type 1
Acromegaly
Authors: Annamaria Colao, Ludovica F. S. Grasso, Andrea Giustina, Shlomo Melmed, Philippe Chanson, Alberto M. Pereira, Rosario Pivonello
Journal: Nature Reviews Disease Primers (2019)

Acromegaly is characterized by increased release of growth hormone and, consequently, insulin-like growth factor I (IGF1), most often by a pituitary adenoma. Prolonged exposure to excess hormone leads to progressive somatic disfigurement and a wide range of systemic manifestations that are associated with increased mortality. Although considered a rare disease, recent studies have reported an increased incidence of acromegaly owing to better disease awareness, improved diagnostic tools and perhaps a real increase in prevalence. Acromegaly treatment approaches, which include surgery, radiotherapy and medical therapy, have changed considerably over time owing to improved surgical procedures, development of new radiotherapy techniques and availability of new medical therapies. The optimal use of these treatments will reduce mortality in patients with acromegaly to levels in the general population. Medical therapy is currently an important treatment option and can even be the first-line treatment in patients with acromegaly who will not benefit from or are not suitable for first-line neurosurgical treatment. Pharmacological treatments include somatostatin receptor ligands (such as octreotide, lanreotide and pasireotide), dopamine agonists and the growth hormone receptor antagonist pegvisomant. In this Primer, we review the main aspects of acromegaly, including scientific advances that underlie expanding knowledge of disease pathogenesis, improvements in disease management and new medical therapies that are available and in development to improve disease control. Acromegaly is a hormonal disorder that is usually caused by a growth hormone-secreting pituitary tumour. This Primer by Colao and colleagues reviews the pathogenesis, diagnosis and management of acromegaly and discusses the quality of life of patients and future outlooks.
Medical News
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CRISPR and biochemical screens identify MAZ as a cofactor in CTCF-mediated insulation at Hox clusters
Authors: Havva Ortabozkoyun, Pin-Yao Huang, Hyunwoo Cho, Varun Narendra, Gary LeRoy, Edgar Gonzalez-Buendia, Jane A. Skok, Aristotelis Tsirigos, Esteban O. Mazzoni, Danny Reinberg
Journal: Nature Genetics (2022)

Abstract CCCTC-binding factor (CTCF) is critical to three-dimensional genome organization. Upon differentiation, CTCF insulates active and repressed genes within Hox gene clusters. We conducted a genome-wide CRISPR knockout (KO) screen to identify genes required for CTCF-boundary activity at the HoxA cluster, complemented by biochemical approaches. Among the candidates, we identified Myc-associated zinc-finger protein (MAZ) as a cofactor in CTCF insulation. MAZ colocalizes with CTCF at chromatin borders and, similar to CTCF, interacts with the cohesin subunit RAD21. MAZ KO disrupts gene expression and local contacts within topologically associating domains. Similar to CTCF motif deletions, MAZ motif deletions lead to derepression of posterior Hox genes immediately after CTCF boundaries upon differentiation, giving rise to homeotic transformations in mouse. Thus, MAZ is a factor contributing to appropriate insulation, gene expression and genomic architecture during development.