tbuckley/cabot-search huggingface dataset:
Annals Graphic Medicine - Masked Facies
Authors: Matthew S. Krantz
Journal: Annals of Internal Medicine (2020)

Web Exclusives7 July 2020Annals Graphic Medicine - Masked FaciesFREEMatthew S. Krantz, MDMatthew S. Krantz, MDVanderbilt University Medical Center, Nashville, Tennessee (M.S.K.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/G20-0052 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Download figure Download PowerPoint Comments0 CommentsSign In to Submit A Comment Luigi BDept Heamthology Ospedale San FRancesco Nuoro Sardinia (Italy)3 June 2020 Bellissimo!! The simple way to share our feelings in everyday practice Disclosures: Non conflicts of interest Author, Article, and Disclosure InformationAffiliations: Vanderbilt University Medical Center, Nashville, Tennessee (M.S.K.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=G20-0052.Author/Illustrator Information: Matthew S. Krantz, MD; e-mail, matthew.s.[email protected]org.This article was published at Annals.org on 2 June 2020. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 7 July 2020Volume 173, Issue 1Page: W12-W13KeywordsDisclosureHealth care ePublished: 2 June 2020 Issue Published: 7 July 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Myeloid neoplasm with <scp>PDGFRB</scp> rearrangement, presenting as systemic mastocytosis‐chronic eosinophilic leukemia
Authors: Habib Moshref Razavi, Richard Yu
Journal: American Journal of Hematology (2022)

A 67-year-old male with history of epigastric pain, significant pruritus, and rash (on arms and legs bilaterally, back, and buttocks) is described. Other pertinent symptoms reported by the patient included fatigue, abdominal distension, infrequent night sweats and 25 lb. weight loss. He presented with anemia (hemoglobin at 100 g/L, MCV is at 97), neutrophilia (10.2 × 109/L), eosinophilia (3.1 × 109/L), basophilia (11.2 × 109/L), and massive splenomegaly (23 cm). Testing for BCR-ABL and JAK2 was negative. On this backdrop, a bone marrow aspiration and biopsy was performed. Circulating normal and atypical mast cells were seen on peripheral blood (Image, panel A, ×50 magnification). Bone marrow aspiration was a dry tap. Trephine biopsy revealed a hypercellular bone marrow with marked eosinophilic and megakaryocytic hyperplasia and a large mast cell infiltrate (70% of cellularity; Image, Hematoxylin and Eosin stain, panel B, ×10, and panel C, ×50 magnification). Mast cells expressed tryptase, CD117 and CD25 but not CD2 (Image, panels D–G, ×4 with inset ×20 magnification, respectively). Reticulin and trichrome stains showed significant fibrosis with deposition of collagen (MF 3/3, Image, panels H and I, respectively, ×4 with inset ×20 magnification). Further testing revealed a PDGFRB (5q32) rearrangement and ruled out a KIT D816V mutation. Seemingly, with circulating mast cells, diagnosis of mast cell leukemia was entertained. However, this diagnosis requires >10% circulating mast cells in the peripheral blood or >20% atypical mast cells in nonspicular parts of an aspirate. Flow cytometry of the blood (albeit on a 6-day-old sample) showed 0.4% circulating mast cells. Accordingly, the diagnosis of PDGRFB rearranged chronic eosinophilic leukemia with a CD25+ mast cell infiltrate (meeting the criteria for systemic mastocytosis) was favored. This patient was initially managed with prednisone (20 mg daily) showing a mild improvement of his rash and pruritus. He was subsequently treated with imatinib mesylate (200 mg daily) at which time a prednisone taper was commenced. Biweekly monitoring is instituted to track his hematologic parameters. A variety of PDGFRB fusion proteins are associated with myeloid/lymphoid neoplasms with eosinophilia. The most common presentation of this myeloid neoplasm includes features of chronic myelomonocytic leukemia with eosinophilia. Other less frequent presentations include features similar to atypical chronic myeloid leukemia and chronic eosinophilic leukemia not otherwise specified among others. Association of this rearrangement with systemic mastocytosis is quite rare. The author declares that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported. Data sharing not applicable - no new data generated.
Grants for Scientific Research
Authors: F. Fowke
Journal: BMJ (1901)

researches therein described have already been noticed in this JOURNAL.6The first chapters are devoted to a description of the method of culture which has been employed-that of incubating portions of the new growths themselves, while taking the most careful precautions against exposure to a temperature lower than the body temperature.two characteristic forms of the cultivated organism are described-a young small golden-coloured form, and a larger which con- sists of a capsule enclosing bodies morphologically similar to
Olaparib Keeps Hereditary Breast Tumors in Check
Journal: Cancer Discovery (2017)

In the phase III OlympiAD study, tumors shrank in about 60% of women with BRCA mutation-associated metastatic breast cancer who received the PARP inhibitor olaparib compared with 29% who received chemotherapy; the median time to disease progression was 7 months compared with 4.2 months, respectively. These findings are the first to demonstrate that a PARP inhibitor can improve progression-free survival in metastatic, hereditary breast cancer.
CLINICAL NOTES ON CHOLERA
Authors: W. L. Lindsay
Journal: BMJ (1854)

ouomhL?IoNla..O1tW.Ydoby sig stad of diminsn o??Zabihty of the spinal mamw.He then the rule by whic we ae to be gidd. 0The propriety and the extent of bloodletting must be em d not by the violence of the disa, but by the state of the
<i>Erratum:</i> Vol. 70, No. 36
Journal: MMWR Morbidity and Mortality Weekly Report (2021)

on page 1252, in the Table, the second footnote should have read, " † ED visit data are from the National Syndromic Surveillance Program (NSSP).Data are limited to ED visits with a discharge diagnosis.Data from Hawaii and Ohio are not included.Fewer than 50% of facilities in California, Iowa, Minnesota, and Oklahoma report to NSSP.In HHS Region 7, fewer than 50% of all ED visits have a discharge diagnosis."On page 1253, the title for Figure 2 should have read, "Number of COVID-19 hospitalizations and percentage of COVID-19 hospitalizations resulting in intensive care unit admission or invasive mechanical ventilation among persons aged 0-17 years, by age group -United States, August 1, 2020-August 21, 2021."
SportsMedUpdate
Authors: Martin P Schwellnus
Journal: British Journal of Sports Medicine (2011)

▶ Logan S, Hunter I, Hopkins JT, et al. Ground reaction force differences between running shoes, racing flats and distance spikes in runners. J Sports Sci Med 2010;9:147–53.[OpenUrl][1][Web of Science][2] ### Background Distance runners use a variety of shoes during training and competition – these shoes may affect running biomechanics, and therefore the risk of injury. ### Research question/s In distance runners, are there any differences in biomechanical variables (ground reaction forces) between running shoes, racing flats and distance spikes? ### Methodology Subjects: 20 intercollegiate distance runners (males=10, 21.6±3.0 years; females=10, 20.0±1.5 years). Experimental procedure: All the subjects were assessed and then ran across a force plate (males at 6.7 m/s and females at 5.7 m/s) in each of the three types of shoes (running shoes – RS, racing flats – RF and distance spikes – DS) in a randomised fashion. Only subjects who exhibited a heel strike were included in the data analysis. Measures of outcome: Differences between shoe types and between genders for peak vertical impact force (BW), loading rate (BW/s), stance time (s), vertical stiffness (BW/m), peak braking force (BW). ### Main finding/s Stance times were shorter and maximum propulsion forces were greater in racing flats compared to running shoes in females. ### Conclusion/s Different shoes (running shoes, racing flats and spikes) alter biomechanical variables in runners – differences between the running shoes were greater in male compared with female athletes. Evidence-based rating : 7/10 Clinical interest rating : 7/10 Type of study : Randomised, controlled, clinical … [1]: {openurl}?query=rft.jtitle%253DJ%2BSports%2BSci%2BMed%26rft.volume%253D9%26rft.spage%253D147%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=000275194600021&link_type=ISI
Cover Image
Journal: Hepatology (2022)

HepatologyVolume 75, Issue 3 COVER IMAGEFree Access Cover Image First published: 14 February 2022 https://doi.org/10.1002/hep.31936AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume75, Issue3March 2022 RelatedInformation
AB0174 Muscle wasting in HTNFTG mice; an animal model for rheumatoid arthritis; due to increased cathepsin l expression
Authors: M. Willburger, B. Niederreiter, A. Jelinek, T. Shvets, J. Smolen, K. Redlich, S. Hayer
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> To investigate the impact of systemic inflammation on skeletal muscles in human tumor necrosis factor transgenic (hTNFtg) animals. <h3>Methods</h3> We isolated triceps surae, as well as rectus abdominis muscles from hTNFtg animals at different time-points of disease starting at week 4 after birth. Muscle weight and body weight were assessed from these animals. Age and sex-matched wildtype (wt) animals served as controls. Moreover, hTNFtg animals were treated with anti-TNF ab (Infliximab, 10mg/kg, 3x per week, i.p.) and we performed quantitative real-time PCR for Cathepsin L, B, S, H, D, LC3-B, MMP-9 and Interleukin (IL)-1 and IL-6 from mRNA isolated from muscle tissues of hTNFtg and wt animals. Muscle tissue sections were also stained for macrophages, neutrophils, T cells and B cells. <h3>Results</h3> We could demonstrate that hTNFtg mice significantly lost muscle weight when compared to sex- and age matched wt animals. Reductions in muscle weight became already manifest at early stages of the disease, at week 4, and continuously progressed until week 16. Due to decreased muscle weight, bodyweight was also significantly lower in hTNFtg animals compared to their wt littermates. We also found significantly increased mRNA expression levels of Cathepsin L, a lysosomal endopeptidase responsible for muscle protein degradation, in muscles from hTNFtg compared to their wt littermates. In contrast, other proteases such as cathepsin B, S, H, D did not significantly increased differ between these 2 genotypes. In addition, we also found LC3B, an enzyme for autophagy-lysosome-mediated proteolysis, to be upregulated in hTNFtg mice compared to wt animals. Moreover, proinflammatory cytokines such as IL-1 and IL-6 were also significantly upregulated in muscles from hTNFtg mice. Interestingly, we observed an increased presence of macrophages and granulocytes in the muscle vascular system but no accumulation of inflammatory cells into the muscle tissue. To evaluate whether the observed changes in muscular tissue are a result of local inflammation or of systemic nature we also investigated the rectus abdominis muscle which is not located between inflamed articular joints. We found elevated levels of Cathepsin L and LC3B in this muscle, indicating that hTNFtg mice suffer from a systemic muscle proteolysis due to systemic inflammation. <h3>Conclusions</h3> Despite spontaneous development of chronic inflamed, erosive arthritis, chronic overexpression of TNF leads to skeletal muscle atrophy due to increased tissue-degrading cathepsin L in hTNFtg animals. <h3>Disclosure of Interest</h3> None Declared
Effective use of image-enhanced endoscopy and endoscopic submucosal dissection for multiple flat non-polypoid colorectal neoplasms
Authors: Takeshi Uozumi, Yutaka Saito, Naoya Toyoshima, Hiroyuki Takamaru, Masau Sekiguchi, Masayoshi Yamada, Seiichiro Abe
Journal: Endoscopy (2022)

Corrected by: Correction: Effective use of image-enhanced endoscopy and endoscopic submucosal dissection for multiple flat non-polypoid colorectal neoplasmsEndoscopy eFirstDOI: 10.1055/a-1799-1644
Standards of Medical Care in Diabetes
Journal: Diabetes Care (2004)

Diabetes is a chronic illness that requires continuing medical care and patient self-management education to prevent acute complications and to reduce the risk of long-term complications. Diabetes care is complex and requires that many issues, beyond glycemic control, be addressed. A large body of evidence exists that supports a range of interventions to improve diabetes outcomes. These standards of care are intended to provide clinicians, patients, researchers, payors, and other interested persons with the components of diabetes care, treatment goals, and tools to evaluate the quality of care. While individual preferences, comorbidities, and other patient factors may require modification of goals, targets that are desirable for most patients with diabetes are provided. These standards are not intended to preclude more extensive evaluation and management of the patient by other specialists as needed. For more detailed information, refer to Bode (Ed.): Medical Management of Type 1 Diabetes (1), Zimmerman (Ed.): Medical Management of Type 2 Diabetes (2), and Klingensmith (Ed): Intensive Diabetes Management (3). The recommendations included are diagnostic and therapeutic actions that are known or believed to favorably affect health outcomes of patients with diabetes. A grading system (Table 1), developed by the American Diabetes Association (ADA) and modeled after existing methods, was utilized to clarify and codify the evidence that forms the basis for the recommendations. The level of evidence that supports each recommendation is listed after each recommendation using the letters A, B, C, or E. ### Classification In 1997, the ADA issued new diagnostic and classification criteria (4); in 2003, modifications were made regarding the diagnosis of impaired fasting glucose (IFG) (5). The classification of diabetes includes four clinical classes:
Abstract 30: Increasing the Uptake of Cardiopulmonary Resuscitation Training Within Australian Cardiac Rehabilitation Programs
Authors: Susie Cartledge, Janet E Bray, Dion Stub, Judith Finn, Lis Neubeck
Journal: Circulation (2018)

Introduction: Outpatient cardiac rehabilitation programs provide an ideal environment to deliver targeted cardiopulmonary resuscitation (CPR) training to cardiac patients and their family members. However, the prevalence of CPR training in Australian programs is low (24%). This study sought to identify the best strategy to implement CPR training into cardiac rehabilitation programs. Hypothesis: We hypothesise that coordinators who receive a higher level of education (information pack including two self-instructional CPR video training kits and a face-to-face education session) compared to those who only receive an information pack, will be more likely to incorporate CPR training into their cardiac rehabilitation programs. Methods: A two-arm randomised controlled implementation study is currently being conducted across Australia. One cardiac rehabilitation coordinator per cardiac rehabilitation program, where the program is not currently providing regular CPR training to patients and families, is eligible to participate. Coordinators will be randomised 1:1 to either receive an information pack or information pack plus face-to-face education session. Results: To date 23 coordinators (59% metropolitan programs, 41% rural programs) have been randomised. Few programs (19%) have previously offered CPR training and only 25% currently include information about CPR. Common barriers to incorporating CPR training into programs are time (71%), resources (67%) and a lack of awareness to include CPR training (24%). Motivations for including CPR training are driven by coordinators assessment that patients and families are interested in CPR training (81%). Implementation data will be presented including information on the level of implementation in addition to a sample of brief qualitative telephone interviews to further discuss enablers and barriers. Conclusions: Cardiac rehabilitation represents a logical location to provide targeted CPR training to high-risk cardiac groups at scale across Australia. This study will aid in better understanding how cardiac rehabilitation coordinators can be supported to enable more programs to incorporate CPR training.
Corrigendum to “Styrene-maleic acid copolymer-encapsulated CORM2, a water-soluble carbon monoxide (CO) donor with a constant CO-releasing property, exhibits therapeutic potential for inflammatory bowel disease” [Journal of Controlled Release 187 (2014) 121]
Authors: Hongzhuan Yin, Jun Fang, Long Liao, Hideaki Nakamura, Hiroshi Maeda
Journal: Journal of Controlled Release (2022)
Ankylosing Spondylitis
Authors: F. D. Hart
Journal: BMJ (1958)

TREATMENT OF ULCERATIVE COLITISFinally, comparison by sequential analysis showed that symptomatic remission and improvement in mucosal appearances were significantly more often induced by potent than by inert treatment.My thanks are due to Glaxo Laboratories, who provided supplies of both potent and inert hydrocortisone for the trial; to Dr. P. Armitage, who designed the sequential analysis chart; and to Professor J. C. Goligher, who performed sigmoidoscopic examinations.
Multidisciplinary teams.
Authors: T Pastor
Journal: BMJ (1980)

and torture. (4)Establishing a network of prominent medical experts in the world who could influence their colleagues in countries acting in breach of the Helsinki agreement to stand firm on the side of human rights.We would welcome any volunteers sympathising with our aims as new members of Amnesty International's medical group.If, however, any sympathisers feel that they cannot fully participate, on account of their present commitments, we would be grateful for help with an occasional case where the authority of a particular specialist might be of value.We would like to extend this invitation to members of the dental and nursing pro- fessions.
Use of lifestyle interventions in primary care for individuals with newly diagnosed hypertension, hyperlipidaemia or obesity: a retrospective cohort study
Authors: Julia M Lemp, Meghana Prasad Nuthanapati, Till W Bärnighausen, Sebastian Vollmer, Pascal Geldsetzer, Anant Jani
Journal: Journal of the Royal Society of Medicine (2022)

Summary Objective Lifestyle interventions can be efficacious in reducing cardiovascular disease risk factors and are recommended as first-line interventions in England. However, recent information on the use of these interventions in primary care is lacking. We investigated for how many patients with newly diagnosed hypertension, hyperlipidaemia or obesity, lifestyle interventions were recorded in their primary care electronic health record. Design A retrospective cohort study. Setting English primary care, using UK Clinical Practice Research Datalink. Participants A total of 770,711 patients who were aged 18 years or older and received a new diagnosis of hypertension, hyperlipidaemia or obesity between 2010 and 2019. Main outcome measures Record of lifestyle intervention and/or medication in 12 months before to 12 months after initial diagnosis (2-year timeframe). Results Analyses show varying results across conditions: While 55.6% (95% CI 54.9–56.4) of individuals with an initial diagnosis of hypertension were recorded as having lifestyle support (lifestyle intervention or signposting) within the 2-year timeframe, this number was reduced to 45.2% (95% CI 43.8–46.6) for hyperlipidaemia and 52.6% (95% CI 51.1–54.1) for obesity. For substantial proportions of individuals neither lifestyle support nor medication (hypertension: 12.2%, 95% CI 11.9–12.5; hyperlipidaemia: 32.2%, 95% CI 31.2–33.3; obesity: 43.9%, 95% CI 42.3–45.4) were recorded. Sensitivity analyses confirm that limited proportions of patients had lifestyle support recorded in their electronic health record before they were first prescribed medication (diagnosed and undiagnosed), ranging from 12.1% for hypertension to 19.7% for hyperlipidaemia, and 19.5% for obesity (23.4% if restricted to Orlistat). Conclusions Limited evidence of lifestyle support for individuals with cardiovascular risk factors (hypertension, hyperlipidaemia, obesity) recommended by national guidelines in England may stem from poor recording in electronic health records but may also represent missed opportunities. Given the link between progression to cardiovascular disease and modifiable lifestyle factors, early support for patients to manage their conditions through non-pharmaceutical interventions by establishing lifestyle modification as first-line treatment is crucial.
Brachial Neuralgia
Authors: W. M. Philip
Journal: BMJ (1950)

BRUCELLOSISBRJITIL_ _~~~~~~~~~~~~~~~~~~~~~~~~~~~~MIA ORA more resistant to aureomycin than Br.abortus), found that relapses occurred even after a course of 21 g., and in one case a blood culture was positive after a course of 25 g.; two other cases had positive cultures after 20 and 21 g.These authors-, at first combined a course of sulphadiazine My thanks are due to Dr.
Polycystic Nephroblastoma
Authors: Boris Datnow
Journal: JAMA (1976)

NEPHROBLASTOMAS are embryonic neoplasms arising from renal tissue. They occur almost exclusively in infants and young children and are seen as congenital neoplasms in fetuses and stillborn infants. These neoplasms are notorious for their silent growth, usually attaining a large size before becoming manifest clinically as a palpable or visible abdominal mass. Grossly, these tumors are usually large, well delineated, and firm. On section, they are solid and contain areas of hemorrhage. Only rarely do they involve the renal pelvis and ureter.<sup>1</sup> This communication reports an unusual variant of a nephroblastoma; it was diffusely cystic and grossly resembled a multilobular cyst of the kidney. <h3>Report of a Case</h3> A 7-month-old male infant was seen because a left abdominal mass was discovered by his mother. Physical examination confirmed the presence of a firm, somewhat movable 8×8 cm mass in the left flank. There were no other abnormal physical findings except