tbuckley/cabot-search huggingface dataset:
Abstract 17361: Phenotype of the Aortic Valve in Patients With Filamin-A Mutations: Echocardiographic Features and Clinical Outcomes
Authors: Romain Capoulade, Caroline Cueff, Nicolas Piriou, Claire Toquet, Stéphanie Blandin, Guillaume Guimbretiere, Toon Omen, Jan J Aalberts, Daniel Berstein, Jonathan A Berstein, Jean-Noel Trochu, Herve Le Marec, Jean Merot, Jean-Jacques Schott, Thierry Le Tourneau
Journal: Circulation (2018)

Background: Filamin-A ( FLNA ) mutations have been associated with the development of mitral valve prolapse and a unique mitral valve features described as a paradoxical restrictive leaflets motion in diastole has been recently described using a comprehensive echocardiographic screening. Polyvalvular diseases have also been reported in these patients, especially affecting the aortic valve. Objectifs: The objective of this study was to perform a comprehensive echocardiographic analysis of the aortic valve (AV) and the proximal aortic root of patients with FLNA mutations, and assess the impact of the aortic disease on outcomes. Methods: We included in this analysis 256 subjects (42±22 years, 136 men, 76 mutated: FLNA+) with confirmed genetic status, from 5 FLNA families. Comprehensive echocardiographic characterization of the aortic valve and the proximal aortic root, including the measurement of the aortic annulus, sinuses of Valsalva, sinotubular junction and ascending aorta, was performed in FLNA+ patients vs control relatives. Results: Overall, 47 subjects (18%) presented an aortic valve alteration: 40 (53%) of FLNA+ compared to 7 (4%) FLNA- subjects (p&lt;0.001). Among the 76 FLNA+ patients, 7 (9%) had a bicuspid aortic valve phenotype as opposed to 2 (1%) in control relatives (p=0.02). The underlying disease affecting the aortic valve was AV sclerosis, stenosis and AV regurgitation with either prolapse or restricted cusps motion. A restrictive opening of the AV was also reported in some patients. Aortic valve mean gradient was slightly increased in FLNA+ compared with FLNA- subjects (5.7±5.1 vs 4.2±1.8 mmHg, P= 0.02). In adults, left ventricular outflow tract diameter (12.5±1.4 vs 12.0±1.0 mm/m 2 ; p=0.02), sinuses of Valsalva (17.8±2.5 vs 16.2±1.9 mm/m 2 ; p&lt;0.001) and sinotubular junction (15.0±2.0 vs 13.7±1.6 mm/m 2 ; p&lt;0.001) were larger in FLNA+ subjects as compared to control relatives. 8 FLNA+ subjects (11%; 6 males) underwent aortic valve-related surgery versus 0 in controls (p&lt;0.001). Survival was also impaired in FLNA+ male subjects (70 year old: 72% vs 64%, p=0.03). Conclusion: The FLNA -mutated patients presented aortic valve disease more frequently, including a higher prevalence of bicuspid valve, stenosis, and regurgitation owing to either cusp prolapsed or restrictive motion. This unique features described in this population was associated with worse clinical outcomes, especially in FLNA+ males. Management and decision making should be done according to the features of these patients with polyvalvular diseases
Survival of young black males with metastatic clear cell renal cell carcinoma.
Authors: Claud Grigg, Sally J. Trufan, Stephen Boyd Riggs, Peter E Clark, Justin T. Matulay, James T Kearns, Jason Zhu, Derek Raghavan, Earle F Burgess
Journal: Journal of Clinical Oncology (2022)

294 Background: Black men have the highest incidence of clear cell renal cell carcinoma (ccRCC) and have a worse prognosis than women or White patients in the curative setting. We previously reported that women with metastatic ccRCC have an inferior prognosis to men which is dynamic with age. The prognosis of Black patients with metastatic ccRCC is not well described. Methods: Clinicopathologic features and survival of patients diagnosed with clinical stage IV ccRCC between 2004-2016 were obtained from the National Cancer Database (NCDB). Patients were stratified according to their age at diagnosis, race, and sex. Uni- and multi-variable chi-square, logistic regression, and overall survival (OS) analyses were used for comparisons. Results: In this cohort, there were 900 Black men, 461 Black women, 13,422 White men, and 6363 White women. Black patients were less likely to have private insurance, lung metastases, or to live in high income zip codes and were more likely to have liver metastases. Compared to White race, Black race was associated with worse OS in the overall cohort (HR 1.17 [95% CI 1.10-1.24], p&lt;0.001; multivariate HR 1.14 [95% CI 1.06-1.21], p&lt;0.001) and in a smaller cohort limited to patients receiving systemic therapy as their initial treatment modality (n=10,869; HR 1.22 [95% CI 1.11-1.33], p&lt;0.001). Within age groups, the highest disparity was observed among younger patients (&lt;50yr: median OS 12.0 vs 22.1mo, p=0.004; 50-64yr: 14.6 vs 20.7mo, p=0.0001; &gt;65yr 9.7 vs 14.5mo, p=0.002). When stratified by age and race, males had similar or superior survival compared to females in most subgroups, however Black males under 50yrs had markedly inferior OS compared with Black females (median OS 10.4mo vs 17.1mo for Black females, p=0.0083) and compared with White patients (Table). Conclusions: Young Black males with metastatic ccRCC demonstrate remarkably poor OS in this cohort; whereas males otherwise have a more favorable prognosis. Potential hypotheses to explain this disparity include differences in obesity and smoking incidence in this population as well as unmeasured factors impacting access to care.[Table: see text]
STAPHYLOCOCCUS TOXOID
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Safety and differential clinical activity of nivolumab plus ipilimumab (nivo-ipi) in patients (pts) with non-clear cell renal cell carcinoma (nccRCC).
Authors: Omar Alhalabi, Nathaniel Wilson, Helen Ajufo, Michael Lehner, Elshad Hasanov, Matthew T Campbell, Amishi Yogesh Shah, Jennifer Wang, Eric Jonasch, John C. Araujo, Jianbo Wang, Jianjun Gao, Sangeeta Goswami, Pavlos Msaouel, Nizar M. Tannir
Journal: Journal of Clinical Oncology (2022)

356 Background: Pembrolizumab monotherapy recently showed promising efficacy in nccRCC. The objective response rate (ORR) by histology was 28.8% for papillary, 9.5% for chromophobe, and 30.8% for unclassified RCC (McDermott, JCO 2021). However, combination immunotherapy data are limited in nccRCC. Methods: We retrospectively evaluated the efficacy and safety of nivo-ipi in pts with nccRCC treated at our institution. ORR and progression-free survival (PFS) were determined using RECIST. Overall survival (OS) was measured from therapy start to death or last follow up. Results: Between November 2017 and July 2020, 27 pts with nccRCC were treated with nivo-ipi at our institution; 25 pts (93%) received nivo-ipi as first-line therapy and 14 pts (52%) had prior nephrectomy. Histology subtypes included 13 (48%) papillary (4 with sarcomatoid features [SF]), 7 (26%) chromophobe (4 with SF), and 7 (26%) unclassified. Sites of metastases included lung in 52%, bone in 37%, and liver in 22% of pts. IMDC risk was favorable (8%), intermediate (48%) and poor (44%). ORR in all pts was 30%; 7 pts achieved a partial response (PR), and 1 patient achieved a complete response (CR). ORR by histology subtype was 54% for papillary, 14% for chromophobe, and 0% for unclassified (table). Clinical benefit (defined as PR, CR, or stable disease [SD] for &gt; 6 months) was achieved in 62% for papillary, 57% for chromophobe, and 29% for unclassified. At a median follow-up time of 17.1 months, for all 27 pts, median PFS was 7.2 months, and median OS was 18.5 months. Median OS per each variant histology subtype was not reached in papillary, 25.7 months in chromophobe, and 7.4 months in unclassified. Median PFS per variant histology subtype was 11.8 months in papillary, 4.0 months in chromophobe, and 2.8 months in unclassified. Seven pts (26%) developed Grade ≥3 toxicity: pneumonitis (2), colitis (2), hepatitis (1), rash (1), and immune-mediated glomerulonephritis (1). Conclusions: In this small retrospective study, nivo-ipi was well-tolerated in pts with nccRCC and yielded high ORR and prolonged PFS in papillary RCC but disappointing efficacy results in chromophobe and unclassified RCC. Molecular studies are ongoing to understand the mechanisms of response and resistance to nivo-ipi in these tumor subtypes.[Table: see text]
Tobacco
Authors: L. Johnston
Journal: BMJ (1947)

JOURNAL827Medical Record, 1922, 20, 209, and asked if any similar cases had been observed in other places, there being an epidemic of ;'paracholera" reported about that time.Nobody took any notice of my short paper and I was disappointed not to hear of any similar cases.As I said, the case was typically Asiatic cholera, with very violent vomiting, diarrhoea, cramps, and collapse, with ricewater stools, but bacteriologically no organism was found but pure streptococcus.I wonder if such symptoms have often been associated with pure streptococcal infection.It is very interesting to note the great difference from the clinical manifestations of staphylococcal infection as reported in the paper recently published.-Iam, etc., Durban.
Abstract 107: The Effects of Hand Placement on Chest Compression Quality in the Pediatric Emergency Department: Findings From the Videography in Pediatric Emergency Research Collaborative
Authors: Alexis B Sandler, Karen O’Connell, Ichiro Watanabe, Richard Hanna, Benjamin T Kerrey, Sage R Myers, Mary E Frey, Aaron J Donoghue
Journal: Circulation (2018)

Introduction: Guidelines for infant cardiopulmonary resuscitation (CPR) recommend two finger (2F) technique for one-rescuer chest compressions (CCs) and a two-thumb encircling (2T) for two-rescuers CCs. Pediatric guidelines recommend either a one-handed (1H) or two-handed (2H) technique based on provider judgement. Previous small, single site studies suggest that 2T compressions are more effective for infant CPR than 2F and 1H. Hypothesis: To combine video review and monitor-defibrillator CC analysis to determine the effects of hand placement on CC quality in a pediatric emergency department (PED). Methods: Data was obtained from the Videography in Pediatric Emergency Resuscitation (VIPER) Collaborative, a prospective observational resuscitation database from 3 tertiary PEDs. Participating sites review resuscitations for quality, safety, and research purposes. Rate and depth for continuous CC segments delivered by a single compressor (epoch) were obtained from Zoll R-series monitor-defibrillator, epoch duration and hand position from video, and patient demographics from medical records. Epochs with analyzable video and CC data were eligible for inclusion. Quality of CC rate and depth were evaluated for adherence to 2015 AHA standards. Results: A total of 248 minutes of CCs for 19 patients [14 infants ≤1 year; 5 toddlers 2-4 years] were analyzed. Median CC rates were adherent to AHA standards for toddlers but not infants, where CCs were often too fast (Table 1). CC depth was inadequate in both infant and toddlers. The 2T technique in infants was significantly associated with adherence to AHA standards for rate ( X 2 =4.97; X 2 =3.64) (Table 1). Conclusions: Infant CC rate and depth and toddler CC depth were not adherent to AHA standards. Performing CCs on infants using the 2T technique was most likely to produce CCs at the recommended rate. Further understanding and implementation of techniques to assist with providing high-quality CCs in young patients is needed.
WHO Multinational Project for Childhood Diabetes
Journal: Diabetes Care (1990)

Insulin-dependent diabetes mellitus (IDDM) is one of the most important chronic diseases of children worldwide. IDDM leads to an 8- to 10-fold excess risk of mortality in developed countries, whereas in developing countries, most cases die within a few years. A 60-fold international gradient in IDDM incidence has been reported, and epidemic periods have been identified. A new World Health Organization program, Multinational Project for Childhood Diabetes (Diabetes Mondiale or DIAMOND), has been developed to investigate and characterize global incidence, mortality, and health care. Over 10 yr (1990-1999), this study will collect population-based data concerning IDDM in greater than 90 centers in 50 countries worldwide. The goals of DIAMOND are to collect standard information on incidence, risk factors, and mortality associated with IDDM; evaluate the efficiency and effectiveness of health care and the economics of diabetes; and establish national and international training programs in diabetes epidemiology. It is hoped that the DIAMOND project will be instrumental for the prevention of this serious disease and its sequelae.
Hypermethylation of HOXA10 by in utero Diethylstilbestrol Exposure: An Epigenetic Mechanism for Altered Developmental Programming
Authors: Jason G. Bromer, Jie Wu, Yuping Zhou, Hugh S. Taylor
Journal: Endocrine Reviews (2009)

Diethylstilbestrol (DES) is a non-steroidal estrogen that induces developmental anomalies of the female reproductive tract. The homeobox gene HOXA10 controls uterine organogenesis, and its expression is altered after in utero DES exposure. We hypothesized that an epigenetic mechanism underlies DES-mediated alterations in HOXA10 expression. We analyzed the expression pattern and methylation profile of HOXA10 after DES exposure. Expression of HOXA10 is increased in human endometrial cells after DES exposure, whereas Hoxa10 expression is repressed and shifted caudally from its normal location in mice exposed in utero. CpG methylation frequency in the Hoxa10 intron was higher in DES-exposed offspring compared to controls (P = 0.017). The methylation level of Hoxa10 was also higher in the caudal portion of the uterus after DES exposure at the promoter and intron (P < 0.01). These changes were accompanied by increased expression of DNA methyltransferases 1 and 3b. No changes in methylation were observed after in vitro or adult DES exposure. DES has a dual mechanism of action as an endocrine disruptor; DES functions as a classic estrogen and directly stimulates HOXA10 expression with short-term exposure, however in utero exposure results in hypermethylation of the HOXA10 gene and long-term altered HOXA10 expression. We identify hypermethylation as a novel mechanism of DES induced altered developmental programming.
Posters
Authors: V. M. Gorodetsky, E. M. Shulutko, T. Nishiyama, K. Hanaoka, J. M. Kingsley, J. A. W. Tcijink, K. Haasnoot, S. Ekkelkamp, H. F. Mahicu, A. Vos, R. Anglès, J. R. Masclans, B. Bermejo, R. Ferrer, R. Peracaula, F. J. de Latorre, I. H. Biswas, E. F. M. Wijdicks, D. J. Plevak, I. Le Roy, H. Spapen, K. Jochmans, W. Vleminckx, M. Diltoer, L. Huyghens, D. Pierard, J. De Mey, G. Delvaux, M. C. van Meeteren, R. Braams, P. F. Hulstaert, M. D. Bosaue, J. Vila, M. Palomar, R. Bastin, J. -J. Moraine, G. Bardocsky, R. J. Kahn, C. Mélot
Journal: Intensive Care Medicine (1996)
Mechanistic analysis for the origin of diverse diterpenes in Tripterygium wilfordii
Authors: Lichan Tu, Xinbo Cai, Yifeng Zhang, Yuru Tong, Jian Wang, Ping Su, Yun Lu, Tianyuan Hu, Yunfeng Luo, Xiaoyi Wu, Dan Li, Luqi Huang, Wei Gao
Journal: Acta Pharmaceutica Sinica B (2022)

Tripterygium wilfordii is a valuable medicinal plant rich in biologically active diterpenoids, but there are few studies on the origins of these diterpenoids in its secondary metabolism. Here, we identified three regions containing tandemly duplicated diterpene synthase genes on chromosomes (Chr) 17 and 21 of T. wilfordii and obtained 11 diterpene synthases with different functions. We further revealed that these diterpene synthases underwent duplication and rearrangement at approximately 2.3-23.7 million years ago (MYA) by whole-genome triplication (WGT), transposon mediation, and tandem duplication, followed by functional divergence. We first demonstrated that four key amino acids in the sequences of TwCPS3, TwCPS5, and TwCPS6 were altered during evolution, leading to their functional divergence and the formation of diterpene secondary metabolites. Then, we demonstrated that the functional divergence of three TwKSLs was driven by mutations in two key amino acids. Finally, we discovered the mechanisms of evolution and pseudogenization of miltiradiene synthases in T. wilfordii and elucidated that the new function in TwMS1/2 from the terpene synthase (TPS)-b subfamily was caused by progressive changes in multiple amino acids after the WGT event. Our results provide key evidence for the formation of diverse diterpenoids during the evolution of secondary metabolites in T. wilfordii.
The Poor-Law Report of the Provincial Medical and Surgical Association, 1841
Journal: BMJ (1841)

§ 30.Your committec have thus, at considerable length, submitted to the Association the result of their examination of the commissioners' Report and Ap- pendix, the whole of which (although necessarily par- tial and(I defcctive in its testimony) is sufficient to prove that its juthors and the boards of guardians, with a few honourable exceptions, continue eitlher inable to comprehend, or unwilling practically to ac- lknowledge, the nature of medical duties and respon- sililities, no less than thlle claims of the sick poor.At the very time when the documents, which have now been considered, were in preparation at Somerset House, or in course of publication, your committee received many important communications from pro- vinlcial practitioners.The information thus supplied, in addition to that collected by other medical associations,* or con- taiiied in thle public joumals, clearly showed, what inideed the commissioners confirmed-viz., that thc abuses complained of in 1838, not only still existed, but were almost unabated.§ 31.Two or three flagrant instances of the ini- quitous system pursued with respect to medical ap- pointments, are selected for notice in this Report.
Endoscopy International Open – recently published
Journal: Endoscopy (2021)

Comment on: Prophylactic colectomy and rectal preservation in FAP: systematic endoscopic follow-up and adenoma destruction changes natural history of polyposisEndosc Int Open 2021; 09(07): E1014-E1022DOI: 10.1055/a-1467-6257 Comment on: Artificial intelligence-assisted colonic endocytoscopy for cancer recognition: a multicenter studyEndosc Int Open 2021; 09(07): E1004-E1011DOI: 10.1055/a-1475-3624 Comment on: Gel immersion endoscopy: Innovation in securing the visual field – Clinical experience with 265 consecutive proceduresEndosc Int Open 2021; 09(07): E1123-E1127DOI: 10.1055/a-1400-8289
Prevention of VD in the sexually promiscuous
Authors: E. Scheimann
Journal: JAMA (1966)

<h3>To the Editor:—</h3> There is more to venereal disease than statistics, more involved in defeating it than education and treatment. Because of the human suffering involved, and because of the complicated nature of venereal disease, I want to emphasize one aspect or major factor of venereal disease. Failure to consider it will threaten the success of any campaign. Even the most reluctant have come to admit that marital conflict, promiscuity, and adultery can be of major etiological importance in disease, emphasized in venereal diseases. In the case of adultery, threatened separation from the love object can be devastating to mental as well as physical health. Yet, incredible as it seems, this is not a category in the<i>Index Medicus</i>under which medical literature is coded. The medical profession in the United States exhibits a curious, irrational, and separatist attitude toward all sexual problems, which naturally affects its attitude toward venereal
Incorrect Value
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Accidental hypothermia.
Authors: M. Bloch
Journal: BMJ (1967)

follow-up clinic the results obtained were not far removed from those in healthy adults.The twenty patients with clinical syndromes following surgery for peptic ulcer-that is, recurrent peptic ulceration, afferent or efferent loop hold-up, dumping syndromes, or malabsorptive states-showed evidence of leucocyte ascorbic acid depletion.Patients with duodenal ulcer on admission for surgical management were found to have values similar to those in the subjects with clinical syndromes following operation.Our findings indicate that it is in these patients with symptoms following gastric surgery that ascorbic acid depletion may be expected.-Weare, etc.,