tbuckley/cabot-search huggingface dataset:
Dilation-predominant approach versus routine care in patients with difficult-to-treat eosinophilic esophagitis: a retrospective comparison
Authors: Sydney Greenberg, Nicole C. Chang, S. Ryanne Corder, Craig C. Reed, Swathi Eluri, Evan S. Dellon
Journal: Endoscopy (2021)

Little is known about esophageal dilation as a long-term treatment approach for eosinophilic esophagitis (EoE). We examined the impact of a "dilate and wait" strategy on symptom management and safety of patients with EoE.This retrospective cohort study included two patient groups: those who underwent a dilation-predominant approach (≥ 3 dilations as sole therapy or for histologically refractory disease [> 15 eos/hpf]); and those who had routine care (< 3 dilations or histologic response). Group characteristics were compared and outcomes for the dilation-only group assessed.53/205 patients (26 %) received the dilation-predominant strategy (total 408 dilations), predominantly for histologic treatment nonresponse (75 %). These patients were younger (33 vs. 41 years; P = 0.003), had a narrower baseline esophageal diameter (9.8 vs. 11.5 mm; P = 0.005), underwent more dilations (7.7 vs. 3.4; P < 0.001), but achieved a smaller final diameter (15.7 vs. 16.7 mm; P = 0.01) vs. routine care. With this strategy, 30 patients (57 %) had ongoing symptom improvement, with esophageal caliber change independently associated with symptom response (adjusted odds ratio 1.79, 95 % confidence interval 1.16-2.78); 26 (49 %) used the strategy as a bridge to clinical trials. Over a median follow-up of 1001 days (interquartile range 581-1710), no deaths or dilation-related perforations occurred, but there were nine emergency room visits, including one for post-dilation bleeding and four for food impaction.A dilation-predominant long-term treatment strategy allowed for symptom control or bridge to clinical trials for patients with difficult-to-treat EoE. Close follow-up and monitoring for complications are required.
SPONTANEOUS RUPTURE OF PAPILLARY MUSCLE ASSOCIATED WITH STEROID USE IN A PATIENT WITH COVID-19 PNEUMONIA, WITH A SUCCESSFUL OUTCOME TO IABP AND LEVOSIMENDAM
Authors: Enrique Alessio Garibo Luna, José Ramón Benitez Tirado, Andres Palacios Castañ eda
Journal: Journal of the American College of Cardiology (2021)
British Society of Gastroenterology guidelines on the management of irritable bowel syndrome
Authors: Dipesh H Vasant, Peter A Paine, Christopher J Black, Lesley A Houghton, Hazel A Everitt, Maura Corsetti, Anurag Agrawal, Imran Aziz, Adam D Farmer, Maria P Eugenicos, Rona Moss-Morris, Yan Yiannakou, Alexander C Ford
Journal: Gut (2021)

Irritable bowel syndrome (IBS) remains one of the most common gastrointestinal disorders seen by clinicians in both primary and secondary care. Since publication of the last British Society of Gastroenterology (BSG) guideline in 2007, substantial advances have been made in understanding its complex pathophysiology, resulting in its re-classification as a disorder of gut-brain interaction, rather than a functional gastrointestinal disorder. Moreover, there has been a considerable amount of new evidence published concerning the diagnosis, investigation and management of IBS. The primary aim of this guideline, commissioned by the BSG, is to review and summarise the current evidence to inform and guide clinical practice, by providing a practical framework for evidence-based management of patients. One of the strengths of this guideline is that the recommendations for treatment are based on evidence derived from a comprehensive search of the medical literature, which was used to inform an update of a series of trial-based and network meta-analyses assessing the efficacy of dietary, pharmacological and psychological therapies in treating IBS. Specific recommendations have been made according to the Grading of Recommendations Assessment, Development and Evaluation system, summarising both the strength of the recommendations and the overall quality of evidence. Finally, this guideline identifies novel treatments that are in development, as well as highlighting areas of unmet need for future research.
CHARACTERISTICS OF PATIENTS WITH P.V142I MUTATIONS ASSOCIATED WITH HEREDITARY TRANSTHYRETIN AMYLOIDOSIS: INSIGHTS FROM A GENETIC TESTING PROGRAM
Authors: Keyur B. Shah, Naresh Bumma, Diego Delgado, Andrew Keller, Sami Khella, Aaron Gabriel, Arvind Narayana, Kemi Olugemo
Journal: Journal of the American College of Cardiology (2021)
Abstract 2290: Importance of the Erectile Dysfunction Questionnaire for Geriatric Cardiology Outpatients
Authors: Gisele H Rodrigues, Humberto Pierri, Giuseppe Rosano, Otavio C Gebara, Amit Nussbacher, João Serro-Azul, Catia C Gerbi, Mauricio Wajngarten
Journal: Circulation (2006)

Introduction: The prevalence of erectile dysfunction (ED) and its characteristics among cardiac patients is not well established. The erectile dysfunction international index (EDII) questionnaire i...
<i>COVID-19 Stats:</i> Percentage of Middle and High School Students Aged 13–21 Years Attending In-Person Classes Who Reported Observing Fellow Students Wearing a Mask All the Time,* by School Setting and Activity — United States, October 2020
Authors: Wences Arvelo, Melissa Fahrenbruch, Marisa Hast, Richard Puddy
Journal: MMWR Morbidity and Mortality Weekly Report (2021)

Classrooms Hallways/ Stairwells School buses Restrooms Cafeteria Sports/ Extracurricular activities Outside on school property % of students reporting mask use all the time School setting/activity * Based on responses by students participating in a Falcon-CDC Foundation cross-sectional web panel survey administered using Qaltrics.Students were asked the following question: "Thinking about students you see at school, how often do these students wear masks in the following locations?"Responses ranged from "all the time" to "never."Mask wearing is a critical mitigation strategy in preventing the introduction and spread of SARS-CoV-2, the virus that causes coronavirus 2019 (COVID-19), within school settings.In October 2020, a sample of 3,953 middle and high school students aged 13-21 years who were attending in-person classes were asked about mask use by fellow students in several settings.Approximately 65% of students reported that fellow students wore a mask "all the time" in the classroom and in hallways or stairwells.However, reported use of masks all the time was lower in other indoor locations, including school buses (42%), restrooms (40%), and the cafeteria (when not eating) (36%).Reported observed mask use all the time was lowest during sports or extracurricular activities (28%) and outside on school property (25%).
Response to: ‘Correspondence on ‘EULAR December 2020 View points on SARS-CoV-2 vaccination in patients with RMDs’’ by Bugatti <i>et al</i>
Authors: Johannes W J Bijlsma
Journal: Annals of the Rheumatic Diseases (2021)

It is great to learn that these Italian colleagues take an active and effective role in promoting vaccination in their patients. The more and earlier our patients, and also the entire population, are vaccinated, the better outcomes in health and quality …
Immunogenicity and efficacy of one and two doses of Ad26.COV2.S COVID vaccine in adult and aged NHP
Authors: Laura Solforosi, Harmjan Kuipers, Mandy Jongeneelen, Sietske K. Rosendahl Huber, Joan E.M. van der Lubbe, Liesbeth Dekking, Dominika N. Czapska-Casey, Ana Izquierdo Gil, Miranda R.M. Baert, Joke Drijver, Joost Vaneman, Ella van Huizen, Ying Choi, Jessica Vreugdenhil, Sanne Kroos, Adriaan H. de Wilde, Eleni Kourkouta, Jerome Custers, Remko van der Vlugt, Daniel Veldman, Jeroen Huizingh, Krisztian Kaszas, Tim J. Dalebout, Sebenzile K. Myeni, Marjolein Kikkert, Eric J. Snijder, Dan H. Barouch, Kinga P. Böszörményi, Marieke A. Stammes, Ivanela Kondova, Ernst J. Verschoor, Babs E. Verstrepen, Gerrit Koopman, Petra Mooij, Willy M.J.M. Bogers, Marjolein van Heerden, Leacky Muchene, Jeroen T.B.M. Tolboom, Ramon Roozendaal, Boerries Brandenburg, Hanneke Schuitemaker, Frank Wegmann, Roland C. Zahn
Journal: The Journal of Experimental Medicine (2021)

Safe and effective coronavirus disease–19 (COVID-19) vaccines are urgently needed to control the ongoing pandemic. While single-dose vaccine regimens would provide multiple advantages, two doses may improve the magnitude and durability of immunity and protective efficacy. We assessed one- and two-dose regimens of the Ad26.COV2.S vaccine candidate in adult and aged nonhuman primates (NHPs). A two-dose Ad26.COV2.S regimen induced higher peak binding and neutralizing antibody responses compared with a single dose. In one-dose regimens, neutralizing antibody responses were stable for at least 14 wk, providing an early indication of durability. Ad26.COV2.S induced humoral immunity and T helper cell (Th cell) 1–skewed cellular responses in aged NHPs that were comparable to those in adult animals. Aged Ad26.COV2.S-vaccinated animals challenged 3 mo after dose 1 with a SARS-CoV-2 spike G614 variant showed near complete lower and substantial upper respiratory tract protection for both regimens. Neutralization of variants of concern by NHP sera was reduced for B.1.351 lineages while maintained for the B.1.1.7 lineage independent of Ad26.COV2.S vaccine regimen.
It's not a bug, it's boredom: Effortful willpower balances exploitation and exploration
Authors: Maik Bieleke, Wanja Wolff
Journal: Behavioral and Brain Sciences (2021)

Abstract The continuous revaluation of rewards lies at the core of Ainslie's account of willpower. Yet, he does not explicate the underlying experiential mechanisms. We draw upon theoretical, neuroscientific, and computational evidence to demonstrate that boredom evokes revaluation. By biasing behavior toward exploration, boredom necessitates effortful willpower to balance it against exploitation, thereby rendering suppression a highly adaptive function of willpower.
THE ASSOCIATION BETWEEN SACUBITRIL/VALSARTAN UTILIZATION AND HEALTHCARE COSTS FOR PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION (HFREF) IN MEDICARE SHARED SAVINGS PROGRAM PARTICIPANTS IN 2018
Authors: Xian Shen, Gabriel Sullivan, Mark Adelsberg, Martins Francis, Taylor Schwartz, Allison Petrilla, Cheryl Abbas, Joaquim Cristino
Journal: Journal of the American College of Cardiology (2021)
ISCHEMIC AND BLEEDING OUTCOMES OF CARRIERS OF CYP2C19*17 TREATED WITH CLOPIDOGREL: INSIGHTS FROM THE TAILOR-PCI STUDY
Authors: Derek Yiu Fai So, Linnea Baudhuin, Michael Farkouh, Shaun Goodman, Verghese Mathew, Vishakantha Murthy, Louai Razzouk, Ganesh Raveendran, Kirk Garratt, Alan Wu, Mina Madan, Ryan Lennon, Naveen Pereira
Journal: Journal of the American College of Cardiology (2021)
Frequency and Costs of Out-of-Network Bills for Outpatient Laboratory Services Among Privately Insured Patients
Authors: Aditi P. Sen, Mark K. Meiselbach, Yang Wang, Matthew D. Eisenberg, Gerard F. Anderson
Journal: JAMA Internal Medicine (2021)

Patients may be unaware of which laboratory is processing their clinical tests, limiting their ability to choose an in-network laboratory. Out-of-network laboratory services could increase patients' out-of-pocket costs and their reluctance to obtain necessary tests.To evaluate the frequency and cost of out-of-network bills for outpatient laboratory services compared with other services.This retrospective cohort study of claims data from the Truven MarketScan Commercial Claims database evaluated claims from 3 946 210 individuals (30.5% of the total) in the MarketScan database who were continually enrolled in health maintenance organization plans, preferred provider organization plans, exclusive provider organization plans, or consumer-driven health plans/high-deductible health plans with at least 1 outpatient clinical laboratory service in 2018. Outpatient laboratory services occurred in independent laboratories, physician offices, and outpatient centers. Laboratory bills from January 1, 2010, to December 31, 2018, were studied.Receipt and cost of outpatient laboratory service.The primary outcome was the proportion of outpatient laboratory services billed as out of network. The secondary outcome was the total potential out-of-pocket cost associated with the out-of-network bill, the sum of observed cost sharing, and the potential balance bill.Of the 12 958 130 in the total sample, 30.5% (3 946 210) had a laboratory test, of whom 5.9% received an out-of-network laboratory test. In comparison, 7.1% of the total sample had an emergency department visit, of whom 4.9% had a service billed as out of network, and 1.6% had an inpatient anesthesiology service, of whom 3.4% had an out-of-network service. Observed out-of-pocket spending was $24.59 higher for an out-of-network laboratory service than an in-network laboratory service. In addition, patients with an out-of-network laboratory service may receive an additional balance bill from the laboratory service; the estimated mean balance bill was $80.63. For the most common laboratory services, the total potential out-of-pocket cost associated with an out-of-network bill ranged from $15.68 for venipuncture to $88.09 for lipid panel but was as high as $303.18 for a drug screening test.In this cohort study, out-of-network laboratory services were 5 times more common than out-of-network emergency department visits and 34 times more common than out-of-network anesthesiology services. It is important for patients that consumer protections against out-of-network bills apply to laboratory services.
Apoptotic Osteocytes Promote Myeloma Dissemination to New Bone Sites Via Suppression of Immune Surveillance in Bone Marrow
Authors: Xiaoxiao Hao, Ru Feng, Timothy Trotter, Pramod Gowda, Mary Fok, Xiaoxuan Xu, Denise Peker, Amjad Javed, Yang Yang
Journal: Blood (2017)
3D Printing Unique Nanoclay‐Incorporated Double‐Network Hydrogels for Construction of Complex Tissue Engineering Scaffolds
Authors: Zhongwei Guo, Lina Dong, Jingjing Xia, Shengli Mi, Wei Sun
Journal: Advanced Healthcare Materials (2021)

Abstract The development of new biomaterial inks with good structural formability and mechanical strength is critical to the fabrication of 3D tissue engineering scaffolds. For extrusion‐based 3D printing, the resulting 3D constructs are essentially a sequential assembly of 1D filaments into 3D constructs. Inspired by this process, this paper reports the recent study on 3D printing of nanoclay‐incorporated double‐network (NIDN) hydrogels for the fabrication of 1D filaments and 3D constructs without extra assistance of support bath. The frequently used “house‐of‐cards” architectures formed by nanoclay are disintegrated in the NIDN hydrogels. However, nanoclay can act as physical crosslinkers to interact with polymer chains of methacrylated hyaluronic acid (HAMA) and alginate (Alg), which endows the hydrogel precursors with good structural formability. Various straight filaments, spring‐like loops, and complex 3D constructs with high shape‐fidelity and good mechanical strength are fabricated successfully. In addition, the NIDN hydrogel system can easily be transformed into a new type of magnetic responsive hydrogel used for 3D printing. The NIDN hydrogels also supported the growth of bone marrow mesenchymal stem cells and displayed potential calvarial defect repair functions.
Abstract #4466: Development of 99mTc-EC-AMT for lung and breast tumor imaging in rodents
Authors: FanLin Kong, YinHan Zhang, Mohammad Ali, Richard Mendez, Saady Kohanim, DongFang Yu, David Yang
Journal: Cancer Research (2009)

Purpose: Alpha-methyl tyrosine (AMT) labeled with 18F has been shown as a useful tumor imaging agent by PET (Inoue et al., J Nucl Med. 40(3):399-405, 1999). However, PET tracer production is costly and requires cyclotron and automation. Previously, we reported that cyclam-alpha-methyl-D, L-tyrosine (N4-AMT), an amino acid transporter-based compound, had high accumulation in several tumor models. N4-chemistry is complex due to chemical protection and de-protection steps. Using N, N-ethylene-di-L-cysteine (EC) as a chelator was an alternative due to its easier chemistry and higher hydrophilicity compared to N4. This study was aimed to synthesize 99mTc-EC-AMT and evaluate its potential in tumor imaging. Its in vitro and in vivo tumor uptakes were compared to that of 99mTc-N4-AMT. Methods: EC-AMT precursor was synthesized by reacting EC and 3-bromopropyl AMT (N-BOC, ethyl ester) in ethanolic/potassium carbonate solution. After acid hydrolysis, EC-AMT was obtained in 80-90% yield. 99mTc labeled EC-AMT was obtained in the presence of tin (II) chloride. In vitro cellular uptake of 99mTc-N4-AMT and 99mTc- EC-AMT (0.1mg in 1 uCi/well) was conducted in H441-GL human lung adenocarcinoma epithelial cells (50,000 cells /well) at 0.5-4 hrs. Planar imaging was evaluated in both mammary tumor-bearing rats (0.3mCi/rat, iv) and H441-GL tumor-bearing athymic nude mice (0.2mCi, iv) at 30 and 90 minutes. Results: Structure of EC-AMT was confirmed by 1H, 13C NMR, HPLC and mass spectrometry. Radiochemical purity of 99mTc-EC-AMT was >96% by radioHPLC. In vitro cellular uptake of 99mTc -EC-AMT and 99mTc-N4-AMT in H441-GL cells was 0.8% and 1.2%, respectively. Planar scintigraphy at 30-90 min revealed that 99mTc-EC-AMT had similar tumor/muscle ratios compared to 99mTc-N4-AMT in tumor-bearing rats. (2.72-3.31 vs. 2.3-4.0). Conclusions: Efficient synthesis of EC-AMT was achieved. Rapid and high accumulation of 99mTc-EC-AMT in tumor and low normal tissue uptake were observed in animal models. In vitro cellular uptake and in vivo imaging findings suggest that 99mTc-EC-AMT is less lipophilic than 99mTc-N4-AMT. 99mTc-EC-AMT, a new amino acid transporter-based tracer, is a useful biomarker for tumor imaging.  Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 4466.
RISK OF READMISSION FOLLOWING NSTEMI STRATIFIED BY TREATMENT STRATEGY INTO REVASCULARIZATION VS MEDICAL MANAGEMENT
Authors: Raunak Nair, Michael Johnson, Kathleen Kravitz, Jeevanantham Rajeswaran, Eugene Blackstone, Venu Menon, A. Lincoff, Samir Kapadia, Umesh Khot
Journal: Journal of the American College of Cardiology (2021)
ANTITHROMBOTIC MANAGEMENT OF ATRIAL FIBRILLATION AFTER PERCUTANEOUS CORONARY INTERVENTION OVER 10 YEARS: EVOLUTION AND GUIDELINES UPTAKE
Authors: Marie-Claude Beaulieu, Laurie-Anne Boivin Proulx, Samer Mansour, Alexis Matteau, Francois Gobeil, Brian Potter
Journal: Journal of the American College of Cardiology (2021)
Abstract 14864: Preserved Endothelial Function and Suppressed Local Coagulative and Inflammatory Response After Biodegradable Polymer SES Implantation Compared to Durable Polymer SES
Authors: Koji Yamaguchi, Tetsuzo Wakatsuki, Yutaka Kawabata, Hiroyuki Ito, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Masataka Sata
Journal: Circulation (2017)

Background: We have previously demonstrated local persistent hypercoagulation after durable polymer (DP)-sirolimus-eluting stent (SES) implantation by measuring plasma prothrombin fragment 1+2 (F1+...
Use of Nintedanib and Pirfenidone in Non–Idiopathic Pulmonary Fibrosis Lung Disease
Authors: Krishnan Warrior, Paul A. Chung, Michal Reid, Bradford C. Bemiss
Journal: American Journal of Respiratory and Critical Care Medicine (2021)

"Use of Nintedanib and Pirfenidone in Non–Idiopathic Pulmonary Fibrosis Lung Disease." American Journal of Respiratory and Critical Care Medicine, 204(1), pp. 92–94
REAL WORLD ANALYSIS OF OUTCOMES OF REMOTE PULMONARY ARTERY HEMODYNAMIC MONITORING IN HEART FAILURE PATIENTS WITH REDUCED AND PRESERVED EJECTION FRACTION
Authors: Mansi Oberoi, Naveen Rajpurohit, Marian Petrasko, Tomasz Stys, Adam Stys, Deborah Vicinsky, Orvar Jonsson
Journal: Journal of the American College of Cardiology (2021)
Therapeutic tissue regenerative nanohybrids self-assembled from bioactive inorganic core / chitosan shell nanounits
Authors: Han-Sem Kim, Jung-Hwan Lee, Nandin Mandakhbayar, Guang-Zhen Jin, Sung-Jin Kim, Ji-Young Yoon, Seung Bin Jo, Jeong-Hui Park, Rajendra K. Singh, Jun-Hyeog Jang, Ueon Sang Shin, Jonathan C. Knowles, Hae-Won Kim
Journal: Biomaterials (2021)
THE EFFECT OF OUT-OF-POCKET COST DISCUSSIONS ON WILLINGNESS TO TAKE SACUBITRIL VALSARTAN FOR HEART FAILURE
Authors: Candace Speight, Larry Allen, Scott Halpern, Yi-An Ko, Daniel Matlock, Miranda Moore, Alanna Morris, Birju Rao, Laura Scherer, Mary Catherine Thomson, Peter Ubel, Neal Dickert
Journal: Journal of the American College of Cardiology (2021)
AGE CAC INTERACTION WITH 10-YEAR CV MORTALITY USING MODEL-AGNOSTIC INTERPRETATION OF MACHINE LEARNING: THE CAC CONSORTIUM
Authors: Benjamin Goebel, Benjamin C. Lee, Yao Lu, Yeonyee Yoon, Lohendran Baskaran, Gabriel Maliakal, Umberto Gianni, Sara Tantawy, Maxim Bax, Partho P. Sengupta, Piotr Slomka, Damini Dey, Alan Rozanski, Donghee Han, Daniel Berman, Matthew J. Budoff, Michael Miedema, Khurram Nasir, John Rumberger, Seamus Whelton, Michael Blaha, Leslee Shaw, Fay Y. Lin
Journal: Journal of the American College of Cardiology (2021)
3D TRANSESOPHAGEAL ECHOCARDIOGRAPHY FOR GUIDING TRANSCATHETER AORTIC VALVE REPLACEMENT WITHOUT PRIOR CARDIAC COMPUTED TOMOGRAPHY IN PATIENTS WITH RENAL DYSFUNCTION
Authors: Paulina Skaff, Karthik Seetharam, Samian Suleiman, Bryan Raybuck, Mohammad Akram Kawsara, Lawrence Wei, Chris Cook, Vinay Badhwar, Ramesh Daggubatti, James Mills, Partho Sengupta, Yasmin Hamirani
Journal: Journal of the American College of Cardiology (2021)
SERIAL MYOCARDIAL PERFUSION IMAGING IN POTENTIAL RENAL TRANSPLANT RECIPIENT: FREQUENCY AND RISK FACTORS ASSOCIATED WITH NEW-ONSET PERFUSION ABNORMALITIES IN END STAGE RENAL DISEASE
Authors: Lehman Godwin, Ryan Cousins, Bill Joe Mullinax, Adam Mitchell, Andrew Smith, Thomas Pearson, Kendra Little
Journal: Journal of the American College of Cardiology (2021)
TMEM16A inhibits angiotensin II-induced basilar artery smooth muscle cell migration in a WNK1-dependent manner
Authors: Huaqing Zheng, Xiaolong Li, Xin Zeng, Chengcui Huang, Mingming Ma, Xiaofei Lv, Yajuan Zhang, Lu Sun, Guanlei Wang, Yanhua Du, Yongyuan Guan
Journal: Acta Pharmaceutica Sinica B (2021)

Vascular smooth muscle cell (VSMC) migration plays a critical role in the pathogenesis of many cardiovascular diseases. We recently showed that TMEM16A is involved in hypertension-induced cerebrovascular remodeling. However, it is unclear whether this effect is related to the regulation of VSMC migration. Here, we investigated whether and how TMEM16A contributes to migration in basilar artery smooth muscle cells (BASMCs). We observed that AngII increased the migration of cultured BASMCs, which was markedly inhibited by overexpression of TMEM16A. TMEM16A overexpression inhibited AngII-induced RhoA/ROCK2 activation, and myosin light chain phosphatase (MLCP) and myosin light chain (MLC20) phosphorylation. But AngII-induced myosin light chain kinase (MLCK) activation was not affected by TMEM16A. Furthermore, a suppressed activation of integrinβ3/FAK pathway, determined by reduced integrinβ3 expression, FAK phosphorylation and F-actin rearrangement, was observed in TMEM16A-overexpressing BASMCs upon AngII stimulation. Contrary to the results of TMEM16A overexpression, silencing of TMEM16A showed the opposite effects. These in vitro results were further demonstrated in vivo in basilar arteries from VSMC-specific TMEM16A transgenic mice during AngII-induced hypertension. Moreover, we observed that the inhibitory effect of TMEM16A on BASMC migration was mediated by decreasing the activation of WNK1, a Cl--sensitive serine/threonine kinase. In conclusion, this study demonstrated that TMEM16A suppressed AngII-induced BASMC migration, thus contributing to the protection against cerebrovascular remodeling during AngII-infused hypertension. TMEM16A may exert this effect by suppressing the RhoA/ROCK2/MLCP/MLC20 and integrinβ3/FAK signaling pathways via inhibiting WNK1. Our results suggest that TMEM16A may serve as a novel therapeutic target for VSMC migration-related diseases, such as vascular remodeling.