tbuckley/cabot-search huggingface dataset:
ASSOCIATION OF CHOLESTEROL EFFLUX CAPACITY WITH ADVERSE CARDIOVASCULAR OUTCOMES - A META-ANALYSIS
Authors: Jane J. Lee, Gerald Chi, Clara Fitzgerald, Syed Hassan A. Kazmi, Arzu Kalayci, Serge Korjian, Adam T. Phillips, Danielle Duffy, Alka Shaunik, Bronwyn Kingwell, Robert W. Yeh, Deepak L. Bhatt, C. Michael Gibson
Journal: Journal of the American College of Cardiology (2021)
Tenofovir Alafenamide for Drug-Resistant Hepatitis B: A Randomized Trial for Switching From Tenofovir Disoproxil Fumarate
Authors: Kwan Soo Byun, Jonggi Choi, Ji-Hoon Kim, Yung Sang Lee, Han Chu Lee, Yoon Jun Kim, Byung Chul Yoo, So Young Kwon, Geum-Youn Gwak, Young-Suk Lim
Journal: Clinical Gastroenterology and Hepatology (2021)
SOTAGLIFLOZIN REDUCES TOTAL HOSPITALIZATIONS AND INCREASES DAYS ALIVE AND OUT OF HOSPITAL IN THE SOLOIST-WHF TRIAL
Authors: Michael Szarek, Deepak Bhatt, Philippe Gabriel Steg, Christopher Cannon, Lawrence Leiter, Darren McGuire, Julia Lewis, Matthew Riddle, Adriaan Voors, Marco Metra, Lars Lund, Michel Komajda, Jeffrey Testani, Christopher Wilcox, Piotr Ponikowski, Renato Lopes, Phillip Banks, Eshetu Tesfaye, Justin Ezekowitz, Subodh Verma, Bertram Pitt
Journal: Journal of the American College of Cardiology (2021)
CLINICAL PROFILES, MEDICAL THERAPIES, AND OUTCOMES AMONG PATIENTS HOSPITALIZED FOR HF ACROSS THE SPECTRUM OF KIDNEY FUNCTION: THE GWTG-HF REGISTRY
Authors: Ravi B. Patel, Gregg Fonarow, Stephen Greene, Shuaiqi Zhang, Brooke Alhanti, Adam DeVore, Javed Butler, Paul Heidenreich, Joanna Huang, Michelle Kittleson, Karen Joynt Maddox, Jim McDermott, Anjali Owens, Pamela Peterson, Scott Solomon, Orly Vardeny, Clyde Yancy, Muthiah Vaduganathan
Journal: Journal of the American College of Cardiology (2021)
Lysosomal alkalization to potentiate eradication of intra-osteoblastic Staphylococcus aureus in the bone and joint infection setting
Authors: Lélia Abad, Pierre Chauvelot, Estelle Audoux, Camille Andre, Jérôme Josse, Céline Dupieux, Sébastien Lustig, Tristan Ferry, Paul O. Verhoeven, Alan Diot, Frédéric Laurent, Florent Valour
Journal: Clinical Microbiology and Infection (2021)
SEVERE ATRIAL FIBRILLATION-RELATED FUNCTIONAL TRICUSPID VALVE REGURGITATION: PREDICTORS FOR HEART FAILURE ADMISSIONS
Authors: Lin Fei Perryn Ng, Robin Cherian, Wern Miin Soo, Siew Pang Chan, William Kong, Kian Keong Poh, Raymond Wong, Tiong Cheng Yeo, Lieng Ling, Edgar Tay
Journal: Journal of the American College of Cardiology (2021)
Abstract 14772: Effects of Reallocating Time in Different Physical Activity Intensities and Sleep on Cardiovascular Disease Risk Factors in Asian American Women: A Cross Sectional Modeling Study
Authors: Chorong Park, Britta A Larsen, Yuhe Xia, Simona Kwon, Victoria V Dickson, Harmony Reynolds, Tanya M Spruill
Journal: Circulation (2020)

Introduction: Physical activity (PA), sedentary behavior (SB) and sleep form the finite 24-hour day; changes to one behavior result in changes to the others. Little is known about how shifting the balance of time spent in these behaviors affects cardiovascular (CV) risk factors. The purpose of this study is to model the effects of changes in PA, SB and sleep on body mass index (BMI), waist circumference (WC) and blood pressure (BP) in Asian American women, who have elevated CV risk. Methods: Normotensive middle-aged Asian American women completed 7 days of hip and wrist actigraphy monitoring (Actigraph, GT3X and GT9X) to assess 24-hour activity. Total sleep time was identified using the Cole-Kripke algorithm with sleep diaries, and moderate-to-vigorous PA (MVPA), light PA and SB were classified by Freedson’s cut-points from wake time. Isotemporal substitution models were used to test effects of replacing 30 mins of each behavior with the others on BMI, WC and BP adjusting for age, education and comorbidity. Results: Data from 75 women were included (age=61.4±8.0, 57% college educated, median comorbidities=1[IQR=0-2]). On average, their days were composed of 0.5 hrs MVPA, 6.2 hrs light PA, 10 hrs SB and 5.3 hrs sleep (2.1 hrs non-wear time). In partition models, where all behaviors were entered simultaneously, more MVPA and sleep were associated with lower BMI and WC. In isotemporal substitution models that held total wear time constant (Table 1), replacing 30 mins SB with an equal amount of MVPA or sleep decreased BMI by 1.7 and 0.6 and WC by 4.1 and 1.2 cm. Replacing 30 mins light PA with MVPA or sleep decreased BMI by 1.9 and 0.9 and WC by 4.5 and 1.6 cm. None of the modeled behavior changes affected BP. Conclusion: These findings suggest that substituting 30 mins of SB or light PA with MVPA or sleep could significantly reduce Asian American women’s BMI and WC. Future studies should test the impact of behavioral interventions that promote these changes on CV risk in Asian American women.
ACTIVATION OF MELATONIN RECEPTOR 2 EFFECTIVELY REDUCES CARDIAC ISCHEMIA/REPERFUSION INJURY IN PREDIABETIC RATS
Authors: Kodchanan Singhanat, Nattayaporn Apaijai, Chayodom Maneechote, Thidarat Jaiwongkam, Busarin Arunsak, Chunchai Titikorn, Siriporn Chattipakorn, Nipon Chattipakorn
Journal: Journal of the American College of Cardiology (2021)
PATIENT- AND PROCESS-RELATED CONTRIBUTORS TO THE UNDER-UTILIZATION OF AORTIC VALVE REPLACEMENT IN SEVERE AORTIC STENOSIS
Authors: Laura Flannery, Alex Camacho, Muhammad Etiwy, Ran Liu, Nilay Patel, April Tavil-Shatelyan, Varsha Tanguturi, Jacob Dal-Bianco, Evin Yucel, Rahul Sakhuja, Arminder Jassar, Nathaniel Langer, Ignacio Inglessis, Jonathan Passeri, Judy Hung, Sammy Elmariah
Journal: Journal of the American College of Cardiology (2021)
ADVERSE CARDIOVASCULAR AND OBSTETRIC DELIVERY COMPLICATIONS IN PREGNANT WOMEN WITH VALVULAR HEART DISEASE
Authors: Anum Minhas, Faisal Rahman, Nicole Gavin, Ari Cedars, Arthur Vaught, Jon Resar, Stefano Schena, Sammy Zakaria, Di Zhao, Allison Hays, Erin Michos
Journal: Journal of the American College of Cardiology (2021)
LONG-TERM FOLLOW-UP OUTCOMES OF DAPT SCORE: A LARGE-SAMPLE REAL WORLD STUDY FROM CHINA
Authors: Xueyan Zhao, Jianxin Li, Pei Zhu, Jiawen Li, Yuejin Yang, Runlin Gao, Bo Xu, Yaling Han, Jinqing Yuan
Journal: Journal of the American College of Cardiology (2021)
Association of Infant Physical Development and Rapid Growth With Pubertal Onset Among Girls in Rural China
Authors: Jing Wei, Shuang Liu, Yue Cheng, Wenfang Yang, Zhonghai Zhu, Lingxia Zeng
Journal: JAMA Network Open (2021)

<h3>Importance</h3> Whether physical development and rapid growth during the first 2 years of life are associated with puberty onset in girls remains unclear. <h3>Objective</h3> To examine the associations of infant physical development and rapid growth with the timing of puberty onset in girls. <h3>Design, Setting, and Participants</h3> This prospective birth cohort study included girls whose mothers had participated in a randomized, double-blind cluster trial of micronutrient supplementation with a daily capsule of folic acid, iron and folic acid, or multiple micronutrients during pregnancy. A total of 547 singleton girls in rural western China who were born after 2004 were followed up at 3, 6, 12, and 24 months of age and were eligible for long-term follow-up. Of these, 294 adolescent girls (aged 10-12 years), representing 53.7% of the total sample, were included in the follow-up interview that was conducted from June 1 through December 31, 2016. Data analyses were conducted from November 1, 2019, to May 30, 2020. <h3>Exposures</h3> Infant weight and length were assessed at birth and 3, 6, 12, and 24 months of age. Rapid growth, defined as a weight-for-age or length-for-age<i>z</i>score increase of greater than 0.67, was calculated during 5 periods: birth to 3 months, birth to 6 months, 6 to 12 months, 12 to 24 months, and birth to 24 months of age. <h3>Main Outcomes and Measures</h3> Puberty stage was assessed using the standardized Tanner staging system. Onset of puberty was defined as attaining Tanner stage 2 of breast development or pubic hair growth, and the corresponding age at follow-up was recorded. <h3>Results</h3> Of 294 girls included in the analysis (mean [SD] age, 11.25 [0.57] years), the median age of puberty onset was 11 (interquartile range, 10-11) years. A significant association with puberty onset was found for infancy weight-for-age<i>z</i>score at 12 months of age (adjusted hazard ratio [HR], 1.20; 95% CI, 1.01-1.44) and rapid weight gain from birth to 24 months of age (adjusted HR, 1.40; 95% CI, 1.01-1.93) and birth to 3 months of age (adjusted HR, 1.39; 95% CI, 1.02-1.91). However, length-related indicators during early life were not associated with adolescent puberty onset. <h3>Conclusions and Relevance</h3> This study found that a higher weight-for-age<i>z</i>score and rapid weight gain during infancy, particularly from birth to 3 months of age, were associated with an increased likelihood of puberty onset in girls. These findings suggest that weight-related indicators may serve as proxies of puberty onset among adolescent girls.
Abstract 12341: Improvement in Adherence to Guideline Based Therapy in Diabetic Patients Admitted with Acute Coronary Syndrome: Findings from AHA Get With the Guidelines Program
Authors: Prakash Deedwania, Kamal Kotak, Gregg Fonarow, Christopher Cannon, Warren Laskey, Frank Peacock, Wendy Pan, Deepak Bhatt
Journal: Circulation (2012)

Objective: To evaluate and compare characteristics, hospital length of stay, in-hospital mortality and temporal trends in adherence to guideline based therapy at discharge among diabetic (DM) and n...
DEGENERATIVE BIOPROSTHETIC AORTIC VALVE WITH LEAFLET PROLAPSE MASQUERADING AS SEVERE AORTIC STENOSIS: ROLE OF MULTI-MODALITY IMAGING
Authors: Pratik Agrawal, Moinuddin Syed, Irfan Zeb, Sudarshan Balla, Yasmin Hamirani
Journal: Journal of the American College of Cardiology (2021)
Use of peritoneal dialysis for acute kidney injury during the COVID-19 pandemic in New York City: a multicenter observational study
Authors: Wei Chen, Nina Caplin, Osama El Shamy, Shuchita Sharma, Maryanne Y. Sourial, Michael J. Ross, Mina H. Sourial, Kalyan Prudhvi, Ladan Golestaneh, Vesh Srivatana, Rochelle Dalsan, Daniil Shimonov, Luis Sanchez-Russo, Sara Atallah, Jaime Uribarri
Journal: Kidney International (2021)
Clare Gerada: A problem shared
Authors: Clare Gerada
Journal: BMJ (2021)

The mental health of the NHS workforce was a cause for concern even before the pandemic. Workload is a major contributor, as is the feeling of not belonging. Doctors describe feeling more like itinerant workers than valued members of a team. We hear of distressed trainees, passing through programmes without their consultants even knowing their name. Or of professional loneliness as peripatetic working makes it hard to meet colleagues.

Covid-19 has highlighted the importance of staff’s psychological needs, particularly if we expect them to attend to the needs of their own patients. Since March 2020, new services have been introduced for preventing and treating poor mental health. These are welcomed. One …
Neoantigen‐reactive T cell: An emerging role in adoptive cellular immunotherapy
Authors: Yicheng Zhu, Youkun Qian, Zhile Li, Yangyang Li, Bin Li
Journal: MedComm (2021)

Abstract Adoptive cellular immunotherapy harnessing the intrinsic immune system for precise treatment has exhibited preliminary success against malignant tumors. As one of the emerging roles in adoptive cellular immunotherapy, neoantigen‐reactive T cell (NRT) focuses on the antigens expressed only by tumor cells. It exclusively obliterates tumor and spares normal tissues, achieving more satisfying effects. However, the development of NRT immunotherapy remains in a relatively primitive stage. Current challenges include identification of NRTs and maintenance of adoptive cell efficacy in vivo. The possible side effects and other limitations of this treatment also hinder its application. Here, we present an overview of NRT immunotherapy and discuss the progress and challenges as well as the prospects in this promising field.
Fortnightly Review: Callosities, corns, and calluses
Authors: D. Singh, G. Bentley, S. G Trevino
Journal: BMJ (1996)

Dishan Singh, senior lecturera, George Bentley, professora, Saul G Trevino, associate professorb Institute of Orthopaedics, Royal National Orthopaedic Hospital, Stanmore, Middlesex HA7 4LP Baylor College of Medicine, Houston, Texas, USACorrespondence to: Mr Singh.
What Does It Mean to Be a British Isles Lupus Assessment Group–Based Composite Lupus Assessment Responder? Post Hoc Analysis of Two Phase III Trials
Authors: Richard Furie, Eric F. Morand, Ian N. Bruce, David Isenberg, Ronald van Vollenhoven, Gabriel Abreu, Lilia Pineda, Raj Tummala
Journal: Arthritis & Rheumatology (2021)

Objective The British Isles Lupus Assessment Group–based Composite Lupus Assessment (BICLA) is a validated global measure of treatment response in systemic lupus erythematosus (SLE) clinical trials. To understand the relevance of BICLA in clinical practice, we investigated relationships between BICLA response and routine SLE assessments, patient‐reported outcomes (PROs), and medical resource utilization. Methods This was a post hoc analysis of pooled data from the phase III, randomized, placebo‐controlled, 52‐week TULIP‐1 (ClinicalTrials.gov identifier: NCT02446912; n = 457) and TULIP‐2 (ClinicalTrials.gov identifier: NCT02446899; n = 362) trials of intravenous anifrolumab (150/300 mg once every 4 weeks) in patients with moderate‐to‐severe SLE. Changes from baseline to week 52 in clinical assessments, PROs, and medical resource use were compared in BICLA responders versus nonresponders, regardless of treatment assignment. Results BICLA responders (n = 318) achieved significantly improved outcomes compared with nonresponders (n = 501), including lower flare rates, higher rates of attainment of sustained oral glucocorticoid taper to ≤7.5 mg/day, greater improvements in PROs (Functional Assessment of Chronic Illness Therapy–Fatigue, Short Form 36 Health Survey), and fewer SLE‐related hospitalizations/emergency department visits (all nominal P &lt; 0.001). Compared with nonresponders, BICLA responders had greater improvements in global and organ‐specific disease activity (Physician’s Global Assessment, SLE Disease Activity Index 2000, Cutaneous Lupus Erythematosus Disease Area and Severity Index Activity, and joint counts; all nominal P &lt; 0.001). BICLA responders had fewer lupus‐related serious adverse events than nonresponders. Conclusion BICLA response is associated with clinical benefit in SLE assessments, PROs, and medical resource utilization, confirming its value as a clinical trial end point that is associated with measures important to patient care.
Gut as viral reservoir: lessons from gut viromes, HIV and COVID-19
Authors: Markus F Neurath, Klaus Überla, Siew C Ng
Journal: Gut (2021)

The gut microbiota is composed of bacteria, fungi and viruses.1–3 While the presence and composition of the bacteriome have been extensively studied in recent years, the ‘dark matter’ of microbiomes including viruses (viral microbiome or virome) remains incompletely understood.4 Analysis of microbiotic communities in the gut showed that bacteria rapidly colonise the gut after birth, followed by the appearance of prophages by 1 month which are harboured by these bacteria. Subsequently, a gut virome dominated by bacteriophages develops and human viruses can be detected 4 months after birth.5 6 In adults, recent studies have analysed the gut virome in healthy individuals by using metagenomic approaches.7 8 For instance, a metagenome analysis in 1986 individuals identified 33 242 unique viral populations, demonstrating that the human gut contains a vast array of bacteriophages and eukaryotic RNA and DNA viruses with a predominance of bacteriophages. Specifically, several groups of prokaryotic crAss-like, Caudovirales and Microviridae bacteriophages and eukaryotic adenoviruses and herpesviruses were characterised as stable colonisers of the human gut.

Further studies described the existence of individual-specific persistent personal viromes. These viromes displayed marked interindividual heterogeneity with age-dependent changes and were critically dependent on host factors such as geography and ethnicity-distinct diets.9 10 Moreover, the duration of urban residence was associated with the presence of multiple bacteriophages, including Lactobacillus and Lactococcus phages.9 Although the functions of most viruses in the gut viromes have not been fully characterised, it has been suggested that viromes play a crucial role in shaping the gut microbiome and intestinal health under homeostatic conditions.

This concept was underlined by experimental studies in murine dextran sulfate sodium (DSS) colitis.11 12 Treatment of DSS colitis with a cocktail of antiviral nucleoside analogues led to augmented mucosal inflammation, while administration of agonists for Toll-like receptor 3 (TLR3: sensor …
CLINICAL IMPLICATION OF SARCOPENIC OBESITY IN PATIENTS WITH SEVERE AORTIC STENOSIS
Authors: Cristian Garmendia, Guido Chiabrando, Ignacio Seropian, Horacio Medina de Chazal, Mariela Cal, Maximiliano Smietniansky, Mariano Falconi, Sahak Hovsepian, Carla R. Agatiello, Daniel Berrocal
Journal: Journal of the American College of Cardiology (2021)
Dissemination of EAACI food allergy guidelines using a flexible, practical, whole school allergy awareness toolkit
Authors: Jennette Higgs, Kathryn Styles, Sarah Bowyer, Amena Warner, Audrey Dunn Galvin
Journal: Allergy (2021)

Essential training for emergency adrenaline auto-injector administration alone provides an inadequate safeguard in school environments. Recent UK deaths have reinforced the urgency for embedding whole school (WS) allergy awareness to minimise risk. We documented the development of a practical, flexible WS Food Allergy Awareness Toolkit for UK secondary schools.We used a multidisciplinary participatory action research methodology, involving successive modification and retesting of a pragmatic toolkit in 3 case study schools. A School Allergy Action Group drives WS risk assessment, helping schools gradually implement best practice policy in line with their particular needs. Additional schools self-piloted the resulting toolkit with only remote monitoring. School surveys, based on EAACI guidelines were developed to identify priorities and assess change.Effectiveness of the resulting process toolkit, now available online, was independently demonstrated via pre/post-intervention questionnaires from 24/10 pupils with food allergy (FA) and 97/6 pupils without FA, respectively. Pearson correlational analysis showed strong negative relationships between Food Allergy Quality of Life Questionnaire (FAQLQ) at T0 and School Support (SS) at T0 (r = -0.8, P<0.01), and between SS and Self-Efficacy (SE) (r = 0.73, P<0.05). Mean FAQLQ scores improved between T0 (3.3) and T1 (2.5). SE improved for those with FA (mean difference = 1.0). In those without FA, SE (mean difference = 0.9) and Attitudes and Knowledge (mean difference = 0.7) also improved.Full stakeholder involvement in toolkit development encourages usage and, therefore, improves WS community awareness; reduces risk of reactions; fosters a more accepting societal attitude and empowers pupils with/without allergies to self-manage effectively.
IDENTIFYING REASONS FOR STATIN NONADHERENCE IN A DIVERSE, REAL-WORLD POPULATION USING ELECTRONIC HEALTH RECORDS AND NATURAL LANGUAGE PROCESSING
Authors: Ashish Sarraju, Jean Coquet, Antonia Chan, Summer Ngo, Juan Antonio Lossio-Ventura, Tina Hernandez-Boussard, Fatima Rodriguez
Journal: Journal of the American College of Cardiology (2021)
PRESENTATION DELAY AMONG PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION OUTSIDE OF A COVID-19 HOT ZONE
Authors: David McNamara, David Klungle, Stacie Vanoosterhout, Denise Busman, Jessica Parker, Andrew R. Kampfschulte, David Wohns, Stefan Jovinge, Ryan Madder
Journal: Journal of the American College of Cardiology (2021)
LEARNING COLLABORATIVE MODEL USED TO UNDERSTAND AND IMPROVE OPPORTUNITIES FOR APPROPRIATE ANTICOAGULANT THERAPY IN PATIENTS ADMITTED WITH A PRIMARY DIAGNOSIS OF ATRIAL FIBRILLATION
Authors: Anastasia Pargulski, Megan Gibas, Katie Haas, Diane Smith, Jeanne Richmond, Mindy Boardwine, Laurie Freeman, James Allred, Dawn Young, Angela Tsiperfal, Michelle Scharnott, Jeanie Luciano, Renee Sednew, Kathie Thomas
Journal: Journal of the American College of Cardiology (2021)
TRENDS IN ANTICOAGULATION PRESCRIPTION SPENDING AMONG MEDICARE PART D AND MEDICAID BENEFICIARIES BETWEEN 2014 AND 2018
Authors: Angela Duvalyan, Ambarish Pandey, Muthiah Vaduganathan, Utibe Essien, Ethan A. Halm, Gregg Fonarow, Andrew Sumarsono
Journal: Journal of the American College of Cardiology (2021)
GENOTYPIC AND PHENOTYPIC DIFFERENCES AND SIMILARITIES AMONG PATIENTS WITH TRANSTHYRETIN AMYLOIDOSIS OR OTHER INHERITED CARDIOVASCULAR DISEASES: INSIGHTS FROM A GENETIC TESTING PROGRAM
Authors: Andrew Keller, Keyur B. Shah, Diego Delgado, Ajay Vallakati, Olakunle Akinboboye, Catherine Marti, Jill Dolinsky, Aaron Gabriel, Arvind Narayana, Kemi Olugemo
Journal: Journal of the American College of Cardiology (2021)
Clinical characteristics and factors associated with hospital admission or death in 43 103 adult outpatients with coronavirus disease 2019 managed with the Covidom telesurveillance solution: a prospective cohort study
Authors: Youri Yordanov, Aurélien Dinh, Alexandre Bleibtreu, Arthur Mensch, François-Xavier Lescure, Erwan Debuc, Patrick Jourdain, Luc Jaulmes, Agnes Dechartres
Journal: Clinical Microbiology and Infection (2021)

ObjectivesStudies on coronavirus disease 2019 (COVID-19) have mainly focused on hospitalized patients or those with severe disease. We aim to assess the clinical characteristics, outcomes and factors associated with hospital admission or death in adult outpatients with COVID-19.MethodsThis is a prospective cohort of outpatients with suspected or confirmed COVID-19, registered in the Covidom telesurveillance solution for home monitoring of patients with COVID-19 in the Greater Paris area, from March to August 2020. The primary outcome was clinical worsening, defined as hospitalization or death within 1 month after symptom onset.ResultsAmong 43 103 patients, mean age was 42.9 years (SD 14.3 years); 93.0% (n = 40 081) of patients were <65 years old and 61.9% (n = 26 688) were women. Of these 43 103 patients, 67.5% (n = 29 104) completed a medical questionnaire on co-morbidities and symptoms. The main reported co-morbidities were asthma (12.8%; n = 3685), hypertension (12.3%; n = 3546) and diabetes (4.8%; n = 1385). A small proportion of all eligible patients (4.1%, 95% CI 3.9–4.2; 1751/43 103) experienced clinical worsening. The rate of hospitalization was 4.0% (95% CI 3.8%–4.2%; n = 1728) and 0.1% (95% CI 0.1%–0.2%; n = 64) died. Factors associated with clinical worsening were male sex, older age, obesity and co-morbidities such as chronic renal disease or cancer under treatment. Probability of worsening was reduced with anosmia/ageusia.ConclusionsClinical worsening was rare among outpatients. Male sex, older age and co-morbidities such as chronic renal disease, active cancers or obesity were independently associated with clinical worsening. However, our cohort may include patients younger and healthier than the general population.
Abstract 10379: Aspergillus Infective Endocarditis Presenting as Lower Limb Ischemia in Lung Transplant Patient With Cystic Fibrosis
Authors: Timothy Pow, Lara Bakhos, Shruti Patel, Kumaran M Mudaliar
Journal: Circulation (2019)

Intro: Fungal infective endocarditis (IE) accounts for 3% of IE cases & up to 67% of these are Aspergillus fumigatus (Af). Risk factors include prosthetic heart valve, solid organ transplant, & cys...