tbuckley/cabot-search huggingface dataset:
Estimated Medicaid Costs Associated with Hepatitis A During an Outbreak — West Virginia, 2018–2019
Authors: Samantha J. Batdorf, Megan G. Hofmeister, Tamara C. Surtees, Erica D. Thomasson, Shannon M. McBee, Nathan J. Pauly
Journal: MMWR Morbidity and Mortality Weekly Report (2021)

Hepatitis A is a vaccine-preventable disease caused by the hepatitis A virus (HAV). Transmission of the virus most commonly occurs through the fecal-oral route after close contact with an infected person. Widespread outbreaks of hepatitis A among persons who use illicit drugs (injection and noninjection drugs) have increased in recent years (1). The Advisory Committee on Immunization Practices (ACIP) recommends routine hepatitis A vaccination for children and persons at increased risk for infection or severe disease, and, since 1996, has recommended hepatitis A vaccination for persons who use illicit drugs (2). Vaccinating persons who are at-risk for HAV infection is a mainstay of the public health response for stopping ongoing person-to-person transmission and preventing future outbreaks (1). In response to a large hepatitis A outbreak in West Virginia, an analysis was conducted to assess total hepatitis A-related medical costs during January 1, 2018-July 31, 2019, among West Virginia Medicaid beneficiaries with a confirmed diagnosis of HAV infection. Among the analysis population, direct clinical costs ranged from an estimated $1.4 million to $5.6 million. Direct clinical costs among a subset of the Medicaid population with a diagnosis of a comorbid substance use disorder ranged from an estimated $1.0 million to $4.4 million during the study period. In addition to insight on preventing illness, hospitalization, and death, the results from this study highlight the potential financial cost jurisdictions might incur when ACIP recommendations for hepatitis A vaccination, especially among persons who use illicit drugs, are not followed (2).
Moving Toward Health and Social Equity for Women Who Use Cannabis During Preconception, Pregnancy, and Lactation
Authors: Kelly C. Young-Wolff, Lynn D. Silver, Qiana L. Brown
Journal: JAMA Network Open (2021)

Kelly C. Young-Wolff, PhD, MPH; G. Thomas Ray, MBA; Stacey E. Alexeeff, PhD; Sara R. Adams, MPH; Monique B. Does, MPH; Deborah Ansley, MD; Lyndsay A. Avalos, PhD, MPH
Clinical presentation and management of food protein‐induced enterocolitis syndrome in 113 Swedish children
Authors: Josefin Ullberg, Mareike Fech‐Bormann, Ulrika L. Fagerberg
Journal: Allergy (2021)

Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy causing severe acute gastrointestinal symptoms and lethargy, mainly affecting infants and young children. There are geographic variations in its clinical features. This study aimed to describe the clinical characteristics and management of FPIES in Swedish children.The study included children who presented with acute FPIES during 2008-2017. All Swedish pediatric departments (n = 32) were invited to report their known patients. Data were collected through chart reviews and interviews with parents.Eighteen pediatric departments contributed, and 113 patients were included. Most had a family history of atopy (74%), and 51% had an atopic disease. Common trigger foods were cow's milk (26%), fish (25%), oat (22%), and rice (8%). Most patients (85%) reacted to a single food. The median age at first reaction was 3.9 months for cow's milk and 6.0 months for other foods (p < 0.001, range 1.0 month to 9 years). Repetitive vomiting (100%), lethargy (86%), and pallor (61%) were common symptoms; 40% had diarrhea. Sixty percent visited the emergency department, and 27% of all patients were hospitalized. Most patients were diagnosed clinically (81%). Specific IgE for the trigger food was positive in 4/89 tested patients (4%), and skin prick test for the trigger food was positive in 1/53 tested patients (2%).In our Swedish study of 113 children, cow's milk, fish, and oat were the commonest trigger foods. Most patients reacted to a single food, and IgE sensitization was rare.
The transcriptome‐wide landscape of molecular subtype‐specific <scp>mRNA</scp> expression profiles in acute myeloid leukemia
Authors: Tian Mou, Yudi Pawitan, Matthias Stahl, Mattias Vesterlund, Wenjiang Deng, Rozbeh Jafari, Anna Bohlin, Albin Österroos, Loannis Siavelis, Helena Bäckvall, Tom Erkers, Santeri Kiviluoto, Brinton Seashore‐Ludlow, Päivi Östling, Lukas M. Orre, Olli Kallioniemi, Sören Lehmann, Janne Lehtiö, Trung Nghia Vu
Journal: American Journal of Hematology (2021)

Molecular classification of acute myeloid leukemia (AML) aids prognostic stratification and clinical management. Our aim in this study is to identify transcriptome-wide mRNAs that are specific to each of the molecular subtypes of AML. We analyzed RNA-sequencing data of 955 AML samples from three cohorts, including the BeatAML project, the Cancer Genome Atlas, and a cohort of Swedish patients to provide a comprehensive transcriptome-wide view of subtype-specific mRNA expression. We identified 729 subtype-specific mRNAs, discovered in the BeatAML project and validated in the other two cohorts. Using unique proteomics data, we also validated the presence of subtype-specific mRNAs at the protein level, yielding a rich collection of potential protein-based biomarkers for the AML community. To enable the exploration of subtype-specific mRNA expression by the broader scientific community, we provide an interactive resource to the public.
Corrigendum to “Quantum dot labeling using positive charged peptides in human hematopoetic and mesenchymal stem cells” [Biomaterials 32 (2011) 5195–5205]
Authors: Sarah Ranjbarvaziri, Sahar Kiani, Aliasghar Akhlaghi, Ahmad Vosough, Hossein Baharvand, Nasser Aghdami
Journal: Biomaterials (2021)
The first “exclusive COVID-19” endoscopy project
Authors: Giulio Petrocelli, Lorenzo Dioscoridi, Edoardo Forti, Francesco Pugliese, Marcello Cintolo, Giulia Bonato, Roberto Rosa, Massimiliano Mutignani
Journal: Endoscopy (2021)

The "second wave" of the outbreak of COVID-19 confirmed the need for long-term projects to manage diagnostic and therapeutic endoscopies in patients testing positive for SARS-COV-2 [1]. Referrals and experience are constantly increasing worldwide, and many patients with COVID-19 undergo endoscopies in many centers [2] [3]. However, implementing strategies to guarantee a complete division of inhospital paths for COVID and COVID-free patients remains challenging and a matter for debate.
Abstract PS7-77: Pathological response after neoadjuvant chemotherapy and long-term outcomes among very young women with HER2 negative breast cancer
Authors: Fernando Valencia, Jorge Laboriano, Luis A. Chirinos, Henry L. Gomez
Journal: Cancer Research (2021)

Abstract Purpose: To describe the pathological response rates (according to the MD Anderson RCB score) achieved by patients with 35 years old or younger, with HER2 negative breast cancer, who received neoadjuvant chemotherapy (NAC) and long term outcomes according to the response. Methods: A retrospective review of 526 medical records of women aged less than or equal to 35 years at diagnosis between 2009 and 2014 at INEN in Lima-Peru, who received NAC for invasive breast cancer, was performed. HER2 positive patients were excluded because of a lack of access to neoadjuvant anti-HER2 therapy during this period in our hospital. Descriptive statistics were used to describe baseline characteristics. OS was calculated from the date of diagnosis to death or last follow-up and presented as Kaplan-Meier curves. The comparison among patients who achieved pCR (RCB-0) and those with residual disease, was based on a log-rank test. Results: Seventy women (One with synchronous bilateral disease) were selected according to selection criteria, median age: 31.7 years old (IQR: 30.0-33.2). Hormone receptor-positive: 38 (53.5%). Clinical stage: IIA: 13(18.3%), IIB: 8(11.3%), IIIA: 25(35.2%), IIIB: 21 (29.6%) and IIIC: 4 (5.6%). Type of NAC: Anthracyclines 6 (8.6%), Anthracyclines and taxanes 55 (78.6%), Platin 5 (7.1%), Taxanes 4 (5.7%). Type of surgery: Conservative 16 (22.5%), radical 50 (70.4%), toilet 5 (7.0%). Type of pathological response RCB-0: 9(12.7%), RCB-I: 2(2.8%), RCB-II:29(40.8%), RCB-III: 24(33.8%), non-pCR: 7(9.9%). With a median follow-up of 46.5m, 5y OS: 100/100/79.3/45.8% according to RCB-0/I/II/III respectively (p=0.004). Conclusions: "Very young" women reach fewer pCR rates than reported for "young" and older women. Even so, RCB-0 can be considered as a biomarker of excellent prognosis and could be used as a surrogate biomarker to evaluate the efficacy of neoadjuvant therapy even in very young women who receive NAC. Citation Format: Fernando Valencia, Jorge Laboriano, Luis A. Chirinos, Henry L. Gomez. Pathological response after neoadjuvant chemotherapy and long-term outcomes among very young women with HER2 negative breast cancer [abstract]. In: Proceedings of the 2020 San Antonio Breast Cancer Virtual Symposium; 2020 Dec 8-11; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2021;81(4 Suppl):Abstract nr PS7-77.
Metformin is associated with decreased risk of basal cell carcinoma: A whole-population case-control study from Iceland
Authors: Jonas A. Adalsteinsson, Sonal Muzumdar, Reid Waldman, Rong Wu, Désirée Ratner, Hao Feng, Jonathan Ungar, Jonathan I. Silverberg, Gudridur H. Olafsdottir, Arni Kjalar Kristjansson, Laufey Tryggvadottir, Jon Gunnlaugur Jonasson
Journal: Journal of the American Academy of Dermatology (2021)
Monoclonal antibodies targeting nonstructural viral antigens can activate ADCC against human cytomegalovirus
Authors: Virginia-Maria Vlahava, Isa Murrell, Lihui Zhuang, Rebecca J. Aicheler, Eleanor Lim, Kelly L. Miners, Kristin Ladell, Nicolás M. Suárez, David A. Price, Andrew J. Davison, Gavin W.G. Wilkinson, Mark R. Wills, Michael P. Weekes, Eddie C.Y. Wang, Richard J. Stanton
Journal: Journal of Clinical Investigation (2021)

Human cytomegalovirus (HCMV) is a ubiquitous pathogen that causes severe disease following congenital infection and in immunocompromised individuals. No vaccines are licensed, and there are limited treatment options. We now show that the addition of anti-HCMV antibodies (Abs) can activate NK cells prior to the production of new virions, through Ab-dependent cellular cytotoxicity (ADCC), overcoming viral immune evasins. Quantitative proteomics defined the most abundant HCMV proteins on the cell surface, and we screened these targets to identify the viral antigens responsible for activating ADCC. Surprisingly, these were not structural glycoproteins; instead, the immune evasins US28, RL11, UL5, UL141, and UL16 each individually primed ADCC. We isolated human monoclonal Abs (mAbs) specific for UL16 or UL141 from a seropositive donor and optimized them for ADCC. Cloned Abs targeting a single antigen (UL141) were sufficient to mediate ADCC against HCMV-infected cells, even at low concentrations. Collectively, these findings validated an unbiased methodological approach to the identification of immunodominant viral antigens, providing a pathway toward an immunotherapeutic strategy against HCMV and potentially other pathogens.
Improving lung health in low-income and middle-income countries: from challenges to solutions
Authors: Jamilah Meghji, Kevin Mortimer, Alvar Agusti, Brian W Allwood, Innes Asher, Eric D Bateman, Karen Bissell, Charlotte E Bolton, Andrew Bush, Bartolome Celli, Chen-Yuan Chiang, Alvaro A Cruz, Anh-Tuan Dinh-Xuan, Asma El Sony, Kwun M Fong, Paula I Fujiwara, Mina Gaga, Luis Garcia-Marcos, David M G Halpin, John R Hurst, Shamanthi Jayasooriya, Ajay Kumar, Maria V Lopez-Varela, Refiloe Masekela, Bertrand H Mbatchou Ngahane, Maria Montes de Oca, Neil Pearce, Helen K Reddel, Sundeep Salvi, Sally J Singh, Cherian Varghese, Claus F Vogelmeier, Paul Walker, Heather J Zar, Guy B Marks
Journal: The Lancet (2021)
Towards Democratizing and Automating Online Conferences: Lessons from the Neuromatch Conferences
Authors: Titipat Achakulvisut, Tulakan Ruangrong, Patrick Mineault, Tim P. Vogels, Megan A.K. Peters, Panayiota Poirazi, Christopher Rozell, Brad Wyble, Dan F.M. Goodman, Konrad Paul Kording
Journal: Trends in Cognitive Sciences (2021)
Carbon fiber reinforced polymers for implantable medical devices
Authors: Corrine Ying Xuan Chua, Hsuan-Chen Liu, Nicola Di Trani, Antonia Susnjar, Jeremy Ho, Giovanni Scorrano, Jessica Rhudy, Antons Sizovs, Graziano Lolli, Nathanael Hernandez, Maria Concetta Nucci, Roberto Cicalo, Mauro Ferrari, Alessandro Grattoni
Journal: Biomaterials (2021)
BCG-induced non-specific effects on heterologous infectious disease in Ugandan neonates: an investigator-blind randomised controlled trial
Authors: Sarah Prentice, Beatrice Nassanga, Emily L Webb, Florence Akello, Fred Kiwudhu, Hellen Akurut, Alison M Elliott, Rob J W Arts, Mihai G Netea, Hazel M Dockrell, Stephen Cose, Sarah Prentice, Beatrice Nassanga, Hellen Akurut, Florence Akello, Fred Kiwudhu, Stephen Cose, Hazel Dockrell, Emily Webb, Alison Elliott, Irene Nabaweesi, Christopher Zziwa, Milly Namutebi, Benigna Namarra, Florence Akello, Esther Nakazibwe, Susan Amongi, Grace Kamukama, Susan Iwala, Caroline Ninsiima, Josephine Tumusiime, Fred Kiwanuka, Saadn Nsubuga, Justin Akello, Sebastian Owilla, Jonathan Levin, Stephen Nash, Prossy Kabuubi Nakawungu, Elson Abayo, Grace Nabakooza, Zephyrian Kaushaaga, Miriam Akello
Journal: The Lancet Infectious Diseases (2021)
Subclinical Atherosclerosis and Brain Metabolism in Middle-Aged Individuals
Authors: Marta Cortes-Canteli, Juan Domingo Gispert, Gemma Salvadó, Raquel Toribio-Fernandez, Catarina Tristão-Pereira, Carles Falcon, Belen Oliva, Jose Mendiguren, Leticia Fernandez-Friera, Javier Sanz, Jose M. Garcia-Ruiz, Antonio Fernandez-Ortiz, Javier Sanchez-Gonzalez, Borja Ibanez, José Luis Molinuevo, Valentin Fuster
Journal: Journal of the American College of Cardiology (2021)

Atherosclerosis has been linked to cognitive decline in late life; however, the impact of cardiovascular risk factors (CVRFs) and subclinical atherosclerosis on brain metabolism at earlier stages remains unexplored. This study sought to determine the association between brain metabolism, subclinical atherosclerosis, and CVRFs in middle-aged asymptomatic individuals. This study included 547 asymptomatic middle-aged participants (50 ± 4 years, 82% men) from the PESA (Progression of Early Subclinical Atherosclerosis) study with evidence of subclinical atherosclerosis. Participants underwent 18F-fluorodeoxyglucose (FDG)-positron emission tomography. Global brain FDG uptake and voxel-wise analyses were used to evaluate the associations of cerebral metabolism with CVRFs and atherosclerotic plaque burden in carotids and femorals assessed by 3-dimensional vascular ultrasound. Global FDG uptake showed an inverse correlation with 30-year Framingham Risk Score (FRS) (β = −0.15, p < 0.001). This association was mainly driven by the presence of hypertension (d = 0.36, p < 0.001). Carotid plaque burden was inversely associated with global brain FDG uptake (β = −0.16, p < 0.001), even after adjusting for 30-year FRS. Voxel-wise approaches revealed that the brain areas most strongly affected by hypometabolism in association with 30-year FRS, hypertension, and carotid plaque burden were parietotemporal regions (angular, supramarginal, and inferior/middle temporal gyri) and the cingulate gyrus. In asymptomatic middle-aged individuals, cardiovascular risk is associated with brain hypometabolism, with hypertension being the modifiable CVRF showing the strongest association. Subclinical carotid plaque burden is also linked to reduced brain metabolism independently of CVRFs. Cerebral areas showing hypometabolism include those known to be affected in dementia. These data reinforce the need to control CVRFs early in life in order to potentially reduce the brain's midlife vulnerability to future cognitive dysfunction.
Safety of low-dose oral minoxidil for hair loss: A multicenter study of 1404 patients
Authors: Sergio Vañó-Galván, Rodrigo Pirmez, Angela Hermosa-Gelbard, Óscar M. Moreno-Arrones, David Saceda-Corralo, Rita Rodrigues-Barata, Juan Jimenez-Cauhe, Wei L. Koh, Janina E. Poa, Rebekka Jerjen, Lara Trindade de Carvalho, Jared Marc John, Corina I. Salas-Callo, Colombina Vincenzi, Lu Yin, Kristen Lo-Sicco, Anna Waskiel-Burnat, Michela Starace, Jose Luis Zamorano, Pedro Jaén-Olasolo, Bianca Maria Piraccini, Lidia Rudnicka, Jerry Shapiro, Antonella Tosti, Rodney Sinclair, Bevin Bhoyrul
Journal: Journal of the American Academy of Dermatology (2021)
Notice of Retraction and Replacement. Li et al. Association Between Maternal Exposure to Magnetic Field Nonionizing Radiation During Pregnancy and Risk of Attention-Deficit/Hyperactivity Disorder in Offspring in a Longitudinal Birth Cohort. <i>JAMA Netw Open</i>. 2020;3(3):e201417
Authors: De-Kun Li
Journal: JAMA Network Open (2021)

Notice of Retraction and Replacement. Li et al. Association between maternal exposure to magnetic field nonionizing radiation during pregnancy and risk of attention-deficit/hyperactivity disorder in offspring in a longitudinal birth cohort. JAMA Netw Open. 2020;3(3):e201417
Abstract PS2-25: Cell-free DNA based detection of mono-allelic versus bi-allelic loss of function for essential genes in breast cancer
Authors: Feng Xie, Haoran Tang, Yue Zhang, Yong Huang
Journal: Cancer Research (2021)

Abstract Background: Breast cancer is the top cancer in women, accounting for over 30% of new cancer cases in women worldwide. Breast cancer is a highly heterogenous disease. Treatment of breast cancer is a very active area in cancer research with significant progresses in recent years. Despite of recent progress in liquid biopsy molecular profiling, blood-based detection of mono-allelic versus bi-allelic loss of function for essential genes such as BRCA, PTEN etc. remains an unmet clinical need for targeted therapy in breast cancer. Methods: We tested over 1000 plasma samples of breast cancer patients using PredicneCARE, a proprietary cell-free DNA (cfDNA) assay, which covered the DNA Damage Repair (DDR) genes in addition to most genes under research in cancer pathways. This blood-based cfDNA assay has a well-tuned capability to reliably detect copy number gain and loss, discriminating bi-allelic versus mono-allelic gene deletions. The assay also has an HRD (Homologous Recombination Deficiency) add-on for the generation of HRD score. Results: PredicineCARE was used to test over 1000 breast cancer patients. The most frequently mutated genes include TP53(59.7%), PIK3CA(47.6%), BRCA2(16.1%), ATM(12.9%), ESR1(12.1%), and ARID1A(10.1%), with cancer variant detection capability down to 0.1% for hotspots; for copy number gain at ≥2.23 and for copy number loss at ≤1.75; and for rearrangements at 0.375%. Interestingly, cfDNA-based gene amplifications were founded in ERBB2, PIK3CA, FGFR1, MYC, etc. and gene deletions were found in important genes such as PTEN, RB, BRCA1/2 etc. Interestingly, we observed significant difference in mutations of key driver genes such as PIK3CA in Chinese versus Caucasian mBC cohorts. Conclusion: The PredicineCARE assay detects blood-based cancer alterations including copy number loss, fusion detection and somatic status evaluation, providing a non-invasive approach to profile important targets including HER2, EGFR, VEGFR, DNA damage repair (BRCA1/2), cell cycle and growth regulations (CDK4/6-RB and PTEN/PI3K/AKT/mTOR), and TRK/ROS1/RET fusions for the treatment of breast cancer. Citation Format: Feng Xie, Haoran Tang, Yue Zhang, Yong Huang. Cell-free DNA based detection of mono-allelic versus bi-allelic loss of function for essential genes in breast cancer [abstract]. In: Proceedings of the 2020 San Antonio Breast Cancer Virtual Symposium; 2020 Dec 8-11; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2021;81(4 Suppl):Abstract nr PS2-25.
Experience with milatuzumab, an anti-CD74 antibody against immunomodulatory macrophage migration inhibitory factor (MIF) receptor, for systemic lupus erythematosus (SLE)
Authors: Daniel J Wallace, Florence Figueras, William A Wegener, David M Goldenberg
Journal: Annals of the Rheumatic Diseases (2021)

Milatuzumab (hLL1) is a humanised IgG1κ antibody that reacts with a cell surface epitope of human CD74, the human leukocyte antigen (HLA) class-II associated invariant chain present on antigen-presenting cells (APCs), including B cells and dendritic cells.1 Although initially studied for oncologic malignancies,2–5 dysregulation of APCs may also occur in non-malignant disorders, and several preclinical studies showed that milatuzumab modestly inhibited B cell proliferation, enhanced spontaneous migration, alterations of adhesion molecule expression and chemotaxis important for lymphocyte recruitment,6 and also reduced production of interferon-α in stimulated peripheral blood mononuclear cells isolated from healthy donors and patients with systemic lupus erythematosus (SLE) (unpublished results). Migration inhibitory factor (MIF) is a cytokine that activates a multicomponent receptor comprising the CD74 ligand-binding …
Congestive Heart Failure and Coronavirus Disease 2019 Illness Severity
Authors: M. Ruge, J. M. D. Gomez, G. G. Nair, S. Fugar, J. D. de Lavallaz, N. Jahan, P. Lavani, J. A. Simmons, A. Rao, K. Marinescu, K. A. Williams, A. S. Volgman, T. M. Suboc
Journal: Circulation (2020)
Effect of public health interventions on COVID-19 cases: an observational study
Authors: Weihong Qiu, Heng He, Peng Zhang, Wenwen Yang, Tingming Shi, Xing Wang, Ailian Chen, Li Xie, Meng Yang, Dongming Wang, Mingyan Li, Weihong Chen
Journal: Thorax (2021)

Background As the epidemic of COVID-19 is gradually controlled in China, a summary of epidemiological characteristics and interventions may help control its global spread. Methods Data for COVID-19 cases in Hubei Province (capital, Wuhan) was extracted until 7 March 2020. The spatiotemporal distribution of the epidemic in four periods (before 10 January, 10–22 January, 23 January–6 February and 7 February–7 March) was evaluated, and the impacts of interventions were observed. Results Among 67 706 COVID-19 cases, 52 111 (76.97%) were aged 30–69 years old, and 34 680 (51.22%) were women. The average daily attack rates (95% CI) were 0.5 (0.3 to 0.7), 14.2 (13.2 to 15.1), 45.7 (44.0 to 47.5) and 8.6 (7.8 to 9.3) cases per 10 6 people in four periods, and the harmonic means (95% CI) of doubling times were 4.28 (4.01 to 4.55), 3.87 (3.78 to 3.98), 5.40 (4.83 to 6.05) and 45.56 (39.70 to 52.80) days. Compared with the first period, daily attack rates rose rapidly in the second period. In the third period, 14 days after 23 January, the daily average attack rate in and outside Wuhan declined by 33.8% and 48.0%; the doubling times increased by 95.0% and 133.2%. In the four periods, 14 days after 7 February, the daily average attack rate in and outside Wuhan decreased by 79.1% and 95.2%; the doubling times increased by 79.2% and 152.0%. Conclusions The public health interventions were associated with a reduction in COVID-19 cases in Hubei Province, especially in districts outside of Wuhan.