tbuckley/cabot-search huggingface dataset:
PDIGREE: An adaptive phase 3 trial of PD-inhibitor nivolumab and ipilimumab (IPI-NIVO) with VEGF TKI cabozantinib (CABO) in metastatic untreated renal cell cancer (Alliance A031704).
Authors: Tian Zhang, Karla V. Ballman, Atish Dipankar Choudhury, Ronald C. Chen, Colleen Watt, Yujia Wen, Tyler Zemla, Hamid Emamekhoo, Shilpa Gupta, Michael J. Morris, Daniel J. George, Toni K. Choueiri
Journal: Journal of Clinical Oncology (2019)

TPS4596 Background: First-line treatment of mRCC has rapidly changed to include IPI-NIVO or CABO, with clinical benefit of each based on the Checkmate 214 and CABOSUN trials. Combination immunotherapy with VEGF therapies have shown benefit in the JAVELIN 101 and KEYNOTE 426 trials over sunitinib. It is yet unclear which patients (pts) benefit most from combination immunotherapy-VEGF inhibitors, and the optimal sequence of drugs. Methods: In an adaptive, randomized, multicenter, phase 3 trial (Alliance A031704, PDIGREE), pts will start treatment with induction IPI 1mg/kg and NIVO 3mg/kg intravenously (IV) once every 3 weeks. Key inclusion criteria include clear cell mRCC, IMDC intermediate or poor risk, Karnofsky performance status &gt;70, and no prior treatments for mRCC. Based on 3-month radiographic assessment (after completing IPI-NIVO combination), pts with complete responses (CR) will undergo maintenance NIVO 480mg IV every 4 weeks, pts with progression of disease (PD) will switch to CABO 60mg oral daily, and pts with non-CR/non-PD will be randomized to NIVO 480mg IV every 4 weeks versus NIVO 480mg IV every 4 weeks with CABO 40mg oral daily. Randomization will be stratified by IMDC risk criteria and presence of bone metastases. The primary endpoint of the study is overall survival (OS). We hypothesize that 3-year OS rate will improve to 70% for NIVO-CABO compared to 60% for NIVO alone; to achieve 85% power with a two-sided alpha of 0.05 and exponential distribution, 696 patients will be randomized. Accounting for 30% patients with either CR or PD, and 5% dropout from toxicity, up to 1046 pts will be enrolled. Key secondary endpoints include PFS, 12-month CR rate, ORR based on RECIST 1.1 and irRECIST criteria, and toxicity profiles. Quality of life will be assessed based on the FKSI-19, PROMIS-fatigue, and EQ5D-5L questionnaires. Biomarkers associated with CR and association of IL-6 with treatment benefit will be assessed. Other tissue-based and plasma-based biomarkers are planned. Enrollment will begin this year. Support from UG1CA189823, U24CA196171; https://acknowledgments.alliancefound.org . Clinical trial information: NCT03793166.
Correction: The Effect of <i>HFE</i> Genotypes on Measurements of Iron Overload
Journal: Annals of Internal Medicine (2002)

Corrections15 October 2002Correction: The Effect of HFE Genotypes on Measurements of Iron OverloadFREESearch for more papers by this authorhttps://doi.org/10.7326/0003-4819-137-8-200210150-00034 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In an article on the relationship of iron measurements to hemochromatosis genotypes (1), some errors in the calculation of the specificity of transferrin saturation measurements were presented in Table 5. Corrected data are given in the current Table.Table. Corrected Values for Specificity of Transferrin Saturation and Serum Ferritin Level for Detection of C282Y/C282Y Homozygosity Reference1. Beutler E, Felitti V, Gelbart T, Ho N. The effect of HFE genotypes on measurements of iron overload in patients attending a health appraisal clinic. Ann Intern Med. 2000;133:329-37. [PMID: 10979877] LinkGoogle Scholar Comments0 CommentsSign In to Submit A Comment PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Effect of HFE Genotypes on Measurements of Iron Overload in Patients Attending a Health Appraisal Clinic Ernest Beutler , Vincent Felitti , Terri Gelbart , and Ngoc Ho Metrics 15 October 2002Volume 137, Issue 8Page: 705KeywordsHemochromatosisSpecificity ePublished: 15 October 2002 Issue Published: 15 October 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
McKeown reassessed.
Authors: S C Farrow
Journal: BMJ (1987)

penetrating chest wounds over the past seven years.No deaths can be attributed to this conservative approach, although urgent thoracotomy, hours after admission, be- cause of sudden haemodynamic deterioration has been required in a few patients in whom immediate thoracotomy was not performed.Transfer to a specialised unit is clearly out of the question for group 3 patients and may be dangerous for those-in group 2. Lack of training in cardiothoracic surgery should not deter the receiving surgical staff from performing immediate or urgent anterolateral thoracotomy when necessary.Likewise, so rarely is cardiopulmonary bypass essential for patient survival that the lack of such facilities should not preclude immediate operation.Only with judicious surgical inter- vention will the excellent results currently reported in the United States be achieved in Britain.7
THE MISSISSIPPI VALLEY MEDICAL ASSOCIATION.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fracture of Menghini needle in liver biopsy
Authors: R. S. Peters
Journal: JAMA (1968)

<h3>To the Editor:</h3> Despite general warnings to the contrary, the liver biopsy is frequently done by those not specifically trained in the technique. This report describes a case in which a replacement obturator for the Menghini liver-biopsy needle was provided by the hospital Central Supply Section without knowledge of the physicians. The use of the replacement obturator by a relatively inexperienced operator resulted in the bending and fracture of the needle near the hub, leaving the distal portion of the metal in the abdominal wall of the patient. <h3>Report of a Case:—</h3> A 70-year old divorced white man in May 1965 complained of pain in the right upper quadrant of six weeks' duration and fever of approximately ten days' duration, after rib fractures which healed spontaneously. The pain was intermittent, unassociated with food intake and was made worse by lying on the right side or the abdomen. The patient had
Meningococcal Jaundice
Authors: C. Crawford
Journal: BMJ (1944)

Simple infective hepatitis becomes a common disease in war- time, and the other diseases giving rise to jaundice are infre- quently met with in healthy young soldiers, so that the occurrence of one of the rarer causes may be worth recording.This case had jaundice as the unusual presenting symptom of a severe acute meningococcal septicaemia, and it is of interest, first, because there were never any symptoms of meningeal involvement, and, secondly, because it was not until the patient was well on the way to recovery, as a result of empirical treat- ment, that a final diagnosis was made. Case HistoryThe paticnt, a soldier aged 23, was admitted to hospital on the second day of an illness which started after an inoculation of T.A.B. and tetanus toxoid.Previously he had been quite well.Five hours after the injection, after dinner, he began to shiver and feel sick, vomiting several times during that and the following day, and twice bringing up fairly copious streaks of blood.Twenty-four hours after the onset he noticed that his urine was dark, and at
JAMA Neurology
Journal: JAMA Neurology (2014)

The mission of JAMA Neurology is to publish scientific information primarily important for those physicians caring for people with neurologic disorders but also for those interested in the structure and function of the normal and diseased nervous system.These specific aims are (1) to make timely publication of original research of the nervous system, (2) to record observations of single patients or groups of patients that will provide new information and insights,(3) to report more basic research that is pertinent to the understanding of disease, (4) to introduce topics of practice, ethics, teaching, and history that are useful, (5) to provide a forum for discussion on topics that may be controversial in this field.This information will be published only after extensive peer review so that originality, clarity, and precision are ensured.
Clinical Pharmacol &amp;amp; Therapeutics, St. Louis
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Preventing injuries, disability, and death at work (starting with vehicles and guns!)
Authors: G. S. Omenn
Journal: JAMA (1982)

In this issue ofThe Journal(p 692), Baker and colleagues report a painstaking epidemiologic investigation of all 148 fatal work-related injuries for one year in the state of Maryland. The diverse causes and circumstances are specified in detail and on a scale far more comprehensible than the National Safety Council's national estimates of 13,000 deaths and more than 200 million lost workdays per year. Surprisingly, perhaps, the leading cause of death by far was motor vehicle accidents of many kinds, and the second leading cause was assault with guns. The majority of deaths involved hazards not addressed by most professional or regulatory efforts to improve occupational safety and health. People who drive on the job, pilots, farmers, and persons at high risk of being assaulted are outside the protection of the Occupational Safety and Health Act for all practical purposes. These results in one state reflect the nationwide shift
Statistical Analysis of Disease Onset and Lifetime Data from Tumorigenicity Experiments
Authors: S. W. Lagakos, Louise M. Ryan
Journal: Environmental Health Perspectives (1985)

We present and discuss several methods for analyzing rodent tumorigenicity experiments. Two approaches are based on the age and tumor status (present/absent) of each animal at the time of death, and assume either that the tumor type is nonlethal or instantly lethal. Two other approaches avoid such restrictive assumptions about tumor lethality by requiring additional types of data. One method assumes that animals are randomly sacrificed at various ages throughout the study. The second approach requires that each animal which develops the tumor be classified as dying either from the tumor or from other causes.
Computer technology suggests new mode of anesthesia delivery
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cryptogenic Facial Paresis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The British Thoracic Society's winter 1994 meeting was held on 12-14 December 1994 at the Queen Elizabeth II Conference Centre, Westminster, London
Authors: P Milligan, Y Kelly, B Brabin, J Reid, E Dunne, S Stenton, G Beach, S Devereux, Hendrick Bourke, Wah Wallace, E Ramage, D Lamb, Sem Howie, J Cailes, A Wells, R Laney, R Coker, R Dubois, M Doherty, M Pearson, J Clarke, A Gates, D Mitchell, Jrw Harris
Journal: Thorax (1995)

of Newcastle upon Tyne We recently performed two investigations ofasthma prevalence involving 876 subjects selected at random from FHSA registers (20-44 years, 289 women) and 1126 shipyard workers (16-25 years, 50 women).All subjects completed a respiratory questionnaire and underwent measurements of airway responsiveness as PD20FEV, to methacholine.The distribution of PD20 measurements was similar among the two populations as was the proportion in each PD20 category with a physician-made diagnosis of asthma (table 1).The overall prevalence of asthma symptoms was higher among the general population than among the workers.The general population sample also showed a close association between 431P on July 12,
The probability of dying of injuries by the year 2000
Authors: L. D. Budnick
Journal: JAMA (1985)

Life tables in which the probability of dying of injuries in the United States from 1985 to 1999 are determined may be useful for clinicians in counseling persons concerning the risk of fatal injuries. Overall, more than 1% of persons aged 10 to 34 years in 1985 probably will die of injuries by the year 2000. For white males aged 5 to 29 years in 1985, white females aged 5 to 19 years in 1985, and black males aged 5 to 24 years in 1985, over half of all the estimated deaths during the next 15 years will be probably due to injuries. (<i>JAMA</i>1985;254:3350-3352)
Phase II trial of sorafenib in persistent or recurrent epithelial ovarian cancer (EOC) or primary peritoneal cancer (PPC): A Gynecologic Oncology Group (GOG) study
Authors: D. Matei, M. W. Sill, K. DeGeest, R. E. Bristow
Journal: Journal of Clinical Oncology (2008)

5537 Background: Sorafenib is a tyrosine kinase inhibitor targeting raf and other receptor kinases (VEGF-R, PDGF-R, Flt3, c-KIT). Sorafenib may have anti-angiogenic activity through inhibition of VEGF-R. This phase II study was conducted to assess the activity and tolerability of sorafenib in patients with recurrent EOC. Methods: This was an open label multi-institutional phase II study employing a two- stage, group sequential design. Eligible patients had persistent or recurrent EOC/PPC after 1–2 prior cytotoxic regimens, measurable or detectable (e.g. by CA125) disease, and GOG performance status ≤ 2. Patients were required to have progressed within 12 months of completing platinum based therapy. Treatment consisted of sorafenib 400 mg orally bid until disease progression or prohibitive toxicity. Primary endpoints were progression-free survival (PFS) at 6 months and toxicity by NCI criteria. Secondary endpoints were tumor response and duration of PFS/overall survival (OS). Results: 73 patients were enrolled from 10/04 to 5/07 and as of 12/2007, 68 patients are evaluable (2 ineligible and 3 too early) for toxicity. Median age was 60 (range 33–80) years and prior treatment consisted of 1 regimen in 40 and 2 regimens in 28 patients. Significant grade 3 and 4 toxicities included: rash (12), metabolic (10), gastrointestinal (3), cardiovascular (2), and pulmonary (2). No treatment related deaths were recorded. Only patients with measurable disease were used to assess efficacy. Among the 59 patients with measurable disease, 12 survived progression-free for at least 6 months. Three patients are yet to be determined. Two patients had partial responses; 20 had stable disease; 30 had progressive disease, and 7 could not have their tumor assessed. Conclusions: Preliminary results suggest that sorafenib is tolerated in patients with recurrent EOC with dermatologic and metabolic abnormalities being the most common toxicities. Efficacy data is expected to reach maturity and be analyzed in the spring of 2007, and comprehensive results will be presented. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Bayer
Illnesses Associated With Occupational Use of Flea-Control Products— California, Texas, and Washington, 1989-1997
Journal: JAMA (1999)

Dips, shampoos, and other insecticide-containing flea-control products can produce systemic illnesses or localized symptoms in the persons applying them. Although these products may pose a risk to consumers, they are particularly hazardous to pet groomers and handlers who use them regularly. Illnesses associated with flea-control products were reported to the California Department of Pesticide Regulation, the Texas Department of Health, and the Washington State Department of Health, each of which maintains a surveillance system for identifying, investigating, and preventing pesticide-related illnesses and injuries. This report describes cases of occupational illnesses associated with flea-control products, summarizes surveillance data, and provides recommendations for handling these products safely.
Stress and Women Physicians
Authors: Nell Pape Warning
Journal: JAMA (1985)

Although the word stress is in the title, and although the first sentence states that this book is about the well-being of today's female physicians, this is really a series of essays about female physicians in the United States. The chapters seem to fall into four categories—facts about women physicians in the United States, problems (stresses) experienced by all American medical students and physicians, problems peculiar to women, and some solutions. Compared with male physicians, women are more often salaried, often in academia. Although their grades are as good as those of their male peers in medical school, they do not advance in rank in academia at the same rate that men do. Their incomes are lower than men's, doubtless because they choose lower paying specialties (pediatrics, psychiatry, and family practice), work fewer hours for fewer years, see fewer patients in an hour, and charge less than do male physicians.
Sphinctérotomie complète avec ou sans macrodilatation pour extraction de grands calculs biliaires: résultats d’une étude multicentrique randomisée
Journal: Endoscopy (2017)

Environ 10 % des calculs cholédociens sont difficiles à extraire lors d’une cholangiographie rétrograde et vont justifier d’une lithotripsie. Plus récemment, a été décrit la possibilité de réaliser une macrodilatation hydrostatique (dilatation supérieure ou égale à 10 mm) pour faciliter l’extraction des gros calculs, sans avoir à recourir à la lithotripsie.
Circulating microRNA-21 and microRNA-122: prognosis prediction and correlation with HIF-1alpha in hepatocellular carcinoma patients treated with transarterial chemoembolization
Authors: Filippo Pelizzaro, Romilda Cardin, Milena Minotto, Chiara Carlotto, Angela Imondi, Anna Sartori, Barbara Penzo, Ambra Sammarco, Giulia Peserico, Camillo Aliberti, Alessandro Vitale, Fabio Farinati
Journal: Journal of Hepatology (2020)
Impact of early prophylactic cranial irradiation with hippocampal avoidance on neurocognitive function in patients with limited disease small cell lung cancer: A multicenter phase II trial (SAKK 15/12)
Authors: H. Vees, F. Caparrotti, A. Xyrafas, A.C. Fuhrer, U.R. Meier, M.T. Mark, O. Elicin, D.M. Aebersold, D.C. Betticher, C. Biaggi Rudolf, K. Ribi, T. Finazzi, D.R. Zwahlen
Journal: Annals of Oncology (2018)
Neoplasma, Bratislava
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal