tbuckley/cabot-search huggingface dataset:
Abstract 16296: Heart Failure-Smart Life: Effects of a Mobile-based Education and Self-management Program for Patients With Heart Failure
Authors: Jeong-Ah Ahn, Eui-Young Choi, Jin-Sun Park
Journal: Circulation (2020)

Introduction: It is considered an important strategy to support heart failure (HF) patients for lifetime self-management. However, some programs for HF patients made them difficult to revisit the hospital or due to economic burden. Therefore, a practical alternative to a comprehensive and user-friendly self-management program for HF patients is needed. Purpose: The aim of this study was to develop a mobile App program for HF patients, and to identify the impact of the program on patients with HF. Methods: We developed a mobile App program, named “HF-Smart Life”. This App installed the configurations and functions of educational materials using pictures and animations, daily health (blood pressure and body weight) check-up diary, Q &amp; A, and 1:1 chat considering user’s convenience. Regarding the experimental study, we employed a quasi-experimental design to evaluate the effects of the program in 74 patients with HF. The experimental group participated to use the mobile App program, including education, feedbacks on self-management, and monitoring in their daily life, for 3 months. Results: Participants of the program (n=36) exhibited significantly improved NYHA functional class and cardiac diastolic function (E/Ea ratio measured by echocardiogram) than the control group (n=38) after 3 months. The mean NYHA function class of the experimental group changed from 2.14 to 1.82, and that of the control group changed from 2.66 to 2.38 (F=9.260, p=.003). Also, the mean E/Ea ratio decreased from 12.24 to 11.35 in the experimental group, whereas that of the control group increased from 14.70 to 16.42 (F=5,280, p=.024). However, there was no significant difference between the groups with cardiac systolic function (left ventricular ejection fraction measured by echocardiogram) and quality of life. Conclusions: This mobile App program showed effectively improvements in HF patients' symptom (functional) class and cardiac diastolic function. Future study is needed to investigate the long-term effects of the mobile-based education and self-management program in HF population. Funding: This research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF-2017R1C1B1007090 &amp; 2019R1F1A1063148).
Abstract 211: UAMC-3203 Reduces the Severity of Post-resuscitation Myocardial Dysfunction in a Rat Model of Cardiac Arrest and Cardiopulmonary Resuscitation
Authors: Tao Jin, Cheng Cheng, Hui Li, Lian Liang, Guozhen Zhang, Jennifer Bradley, Mary Ann A Peberdy, Joseph P Ornato, Wanchun Tang
Journal: Circulation (2020)

Introduction: Previous studies have demonstrated that ferroptosis, a newly defined iron-dependent cell death, mediates ischemia/reperfusion induced cardiomyopathy. However, it is unclear whether ferroptosis plays a role in post-resuscitation myocardial dysfunction (PRMD). This study investigated the effects of UAMC-3203, a novel analog of ferroptosis specific inhibitors, on myocardial function after cardiopulmonary resuscitation (CPR). Hypothesis: Administration of UAMC-3203 during CPR alleviates PRMD in a rat model of cardiac arrest (CA) and CPR. Methods: 18 male Sprague-Dawley rats weighing between 450-550g were randomized into 3 groups: 1) Sham, 2) Control, and 3) UAMC-3203 (5mg/kg, IP at start of precordial compression). Ventricular fibrillation (VF) was induced and continued for 6min. CPR was then initiated for 8min, after which defibrillation was attempted. Ejection fraction (EF), cardiac output (CO) and myocardial performance index (MPI) were measured by echocardiography at baseline, 15min, 1h, 3h and 6h respectively after return of spontaneous circulation (ROSC). Results: A significant reduction in cardiac function was observed after resuscitation. At 15 minutes after ROSC, ultrasound showed no difference in cardiac function between UAMC and control. However, at 1, 3, and 6 h after ROSC, UAMC significantly improved myocardial function (p&lt;0.05) (Fig. 1). Conclusion: A ferroptosis-specific inhibitor, UAMC-3203, alleviated PRMD significantly in a rat of model of CA and CPR. Further study is needed to determine the benefit of this agent in larger animals and potential safety in humans before it can be tested in clinical resuscitation.
Polypill with or without Aspirin in Persons without Cardiovascular Disease
Authors: Salim Yusuf, Philip Joseph, Antonio Dans, Peggy Gao, Koon Teo, Denis Xavier, Patricio López-Jaramillo, Khalid Yusoff, Anwar Santoso, Habib Gamra, Shamim Talukder, Courtney Christou, Preeti Girish, Karen Yeates, Freeda Xavier, Gilles Dagenais, Catalina Rocha, Tara McCready, Jessica Tyrwhitt, Jackie Bosch, Prem Pais
Journal: New England Journal of Medicine (2020)

A polypill comprising statins, multiple blood-pressure-lowering drugs, and aspirin has been proposed to reduce the risk of cardiovascular disease.
Efficacy of utidelone plus capecitabine versus capecitabine for heavily pretreated, anthracycline- and taxane-refractory metastatic breast cancer: final analysis of overall survival in a phase III randomised controlled trial
Authors: B. Xu, T. Sun, Q. Zhang, P. Zhang, Z. Yuan, Z. Jiang, X. Wang, S. Cui, Y. Teng, X.-C. Hu, J. Yang, H. Pan, Z. Tong, H. Li, Q. Yao, Y. Wang, Y. Yin, P. Sun, H. Zheng, J. Cheng, J. Lu, B. Zhang, C. Geng, J. Liu, K. Shen, S. Yu, H. Li, L. Tang, R. Qiu
Journal: Annals of Oncology (2020)
Leukemic cells expressing NCOR1-LYN are sensitive to dasatinib in vivo in a patient-derived xenograft mouse model
Authors: Toshihiro Tomii, Toshihiko Imamura, Kuniaki Tanaka, Itaru Kato, Azusa Mayumi, Emi Soma, Mio Yano, Kenichi Sakamoto, Takashi Mikami, Makiko Morita, Nobutaka Kiyokawa, Keizo Horibe, Souichi Adachi, Tatsutoshi Nakahata, Junko Takita, Hajime Hosoi
Journal: Leukemia (2020)
Abstract 14834: Protective Role of Cardiomyocyte-derived Ddt in Ischemic Cardiomyopathy
Authors: Yina Ma, Xiaoyue Hu, Daniel Pfau, Xiaohong Wu, Veena Rao, Jeffery M Testani, Kenneth B Margulies, Richard Bucala, Lawrence H Young
Journal: Circulation (2020)

Background: D-dopachrome tautomerase (DDT), the only homolog of macrophage migration inhibitory factor (MIF), is a cytokine highly expressed in cardiomyocytes and exerts autocrine-paracrine effects by signaling through the CD74 receptor. Endogenous DDT and MIF prevent acute ischemia-reperfusion injury and pressure overload-induced heart failure in mice. This study investigated whether endogenous cardiomyocyte DDT has a role in ischemic cardiomyopathy (ICM). Methods: LV tissue was obtained from patients with ICM during heart transplantation and from non-transplanted donor hearts. Plasma DDT concentrations were measured in heart failure outpatients with ICM. Cardiomyocyte-specific DDT knockout (cKO) and littermate control (CON) mice underwent MI or sham surgery. Serial echocardiography was performed to assess LV remodeling after MI or sham surgery. Tissue from the non-infarct region was analyzed 3 days and 4 weeks after MI or sham surgery for histology and molecular studies. Results: Cardiac DDT mRNA and protein expression were reduced in LV from patients transplanted for ICM (n=8). Plasma DDT concentrations below the median value were associated with worse survival in ICM outpatients (p&lt;0.05, n=32). In mice, baseline LV function was similar in DDT cKO and CON after sham surgery and 3 days post-MI. However, DDT cKO mice developed more rapid LV dilatation and decreased LV ejection fraction and stroke volume as early as 1-week post-MI (n=4-6/group, all P&lt;0.05). The DDT cKO mice had smaller cardiomyocyte cross-sectional area 4 weeks after MI (p &lt;0.05), as well as early diminished phosphorylation of mTOR and S6-kinase (3 days post-MI). They also showed increased apoptosis 3 days post-MI and an early increase in p38 MAP kinase activation. Conclusion: Cardiomyocyte-derived DDT prevents adverse cardiac remodeling in ICM, potentially through modulating mTOR/S6 kinase (adaptive hypertrophy) and p38 MAP kinase (limiting apoptosis). Down-regulation of DDT in patients with ICM may contribute to the pathogenesis of advanced heart failure.
Abstract 14657: Troponin T I79n Mutation Causes Ca-dependent Action Potential Triangulation in Human Induced Pluripotent Stem Cell Model of Hypertrophic Cardiomyopathy
Authors: Lili Wang, Kyungsoo Kim, Shan Parikh, Adrian Gabriel Cadar, Kevin R Bersell, Huan He, Jose R Pinto, Dmytro Kryshtal, Bjorn C Knollmann
Journal: Circulation (2017)

Background: Mutations in cardiac troponin T (TnT) are linked to a high risk for ventricular arrhythmia and sudden death despite causing little or no cardiac hypertrophy. Studies in mice suggest tha...
Talking at Cross Purposes: Why We Shouldn’t Re-Establish the Relationship Between Theological and Secular Bioethics
Authors: Heidi Matisonn
Journal: The American Journal of Bioethics (2020)

This article is referred to by:The Social Context of Religion in the Jurisdictions of BioethicsResponse to Open Peer Commentaries for "There's No Harm in Talking: Reestablishing the Relationship Between Theological and Secular Bioethics"
Abstract 137: Lack of Racial Diversity in Cardiopulmonary Resuscitation Training Films: A Cross-sectional Analysis
Authors: Courtland Blount, Carlos Lynes, Jamaal Richie, Brittiany Narvaez, Danielle B Green, Crystal M Herrera, Sarah F Sella, Christian H Jara, Tim Ogburn, Eric B Nguyen, Lorrel E Toft
Journal: Circulation (2020)

Introduction: Minorities are less likely to be CPR-trained, and less likely to receive bystander CPR compared to whites. Hypothesis: We hypothesized that modern CPR training films demonstrate poor racial diversity and therefore poor relevance to minority communities. Methods: Using the query “how to do CPR” in Google and YouTube, 350 and 500 films were reviewed. Exclusion criteria included: pre-2015, non-English, non-instructional, pediatric or animal victims, duplicates, parity, or in-hospital cardiac arrest. For each film, 4 racially-diverse evaluators identified the race of the instructor, rescuer, victim, and manikin as “white” or “non-white.” Films were scored on 6 aspects of CPR instruction: scene safety, check responsiveness, activate Emergency Medical Services, proper hand position, accurate rate, and appropriate depth of compressions. Similarly, the race of characters in CPR training films from the American Heart Association (AHA) and American Red Cross (ARC) were analyzed by one self-identified non-white evaluator. Results: Of 72 online films meeting the criteria, 50 used a human instructor (76% white); 19 showed a human victim (84% white); 70 depicted a human rescuer (74% white); and 58 featured a manikin (95% white) (p&lt;0.0001 for all, white v. non-white). Only 10 of 72 films (14%) taught hands-only CPR, featured AT LEAST ONE non-white character, and were of high-quality ( &gt; 5 aspects of CPR instruction). Inter-rater reliability was high (&gt;0.775). We also reviewed 7 ARC and 7 AHA adult CPR training films (2015 or later). Four of 7 AHA films (57%) and 2 of 7 ARC films (29%) featured at least one non-white character (Figure 1). Conclusion: We identified only 10 online high-quality films teaching hands-only CPR which feature at least one non-white character. CPR instructional films from the AHA and ARC showed greater racial diversity. Improved racial representation in CPR training films is important to increase relevance to under-trained minority communities.
Abstract 13213: Correlates of Dietary Self-care Behaviors in Adults With Type 2 Diabetes and Comorbid Heart Failure
Authors: Fekadu Aga, Sandra B Dunbar, Tedla Kebede, Melinda K Higgins, Rebecca A Gary
Journal: Circulation (2020)

Introduction: Multi-morbidity is increasingly recognized to negatively influence self-care behaviors such as dietary adherence in persons living with serious or life-threatening chronic conditions such as type 2 diabetes (T2D) and heart failure (HF). Aim: The aim of this study was to describe demographic, clinical, and psychosocialcorrelates of dietary self-care behaviors in adult patients with T2D and comorbid HF. Methods: The parent study for this secondary analysis was a randomized trial that tested a 6-month integrated self-care intervention for 180 participants with comorbid HF and T2D. Cross-sectional, baseline data was used for the predictive model which included demographic (age, sex, marital status, and education) psychosocial (depression [PhQ-9], self-efficacy [PDSMS], and diabetes knowledge [MDKT]); and clinical variables (years diagnosed with T2D and HF, New York Heart Association (NYHA) functional classification, Charlson comorbidity index (CCI), and implanted cardiac device). The general and specific diet components of the Summary of Diabetes Self-Care Activities (SDSCA) were used to measure dietary self-care behaviors. Correlational bivariate and stepwise linear regression analyses were performed to examine correlates of dietary self-care behaviors. Results: Participants mean age was 58 ±11 years and the majority were male (n = 118, 66%) and African American (n = 119, 66%). Charlson comorbidity &gt;2 ( p &lt;0.05) and implanted device ( p &lt;0.05) predicted lower SDSCA general diet score. Diabetes self-efficacy ( p &lt;0.01) predicted higher SDSCA specific diet score while implanted cardiac device ( p &lt;0.05) predicted lower score, collectively explaining 18.2% of the variance in diabetes-specific dietary self-care behavior. Conclusion: Findings suggest that multimorbidity may increase risk for lower diabetes dietary self-care behaviors, particularly those with more advanced HF requiring an implanted device. Future research should focus on how to promote effective self-care behaviors in persons living with multimorbidity as a strategy to improve clinical outcomes and enhance quality of life.
Abstract 13478: Pulmonary Embolism in Covid-19 Patients:A French Multicentre Cohort Study
Authors: Charles Fauvel, Orianne Weizman, Antonin Trimaille, Delphine Mika, Nathalie Pace, Amine Douair, Eva Barbin, Antoine Fraix, Baptiste Duceau, Willy Sutter, Victore Waldmann, Guillaume Bonnet, Ariel COHEN, Theo Pezel
Journal: Circulation (2020)

Introduction: While pulmonary embolism(PE) appears to be a major issue in Covid-19, data remain sparse. Hypothesis: We aimed to describe the risk factors and baseline characteristics of patients with PE in a cohort of Covid-19 patients. Methods: In a retrospective multicentric observational study, we included consecutive hospitalised patients for Covid-19. Patients without computed tomography pulmonary angiography (CTPA)-proven PE diagnosis and those who were directly admitted to an intensive care unit(ICU) were excluded. Results: Among 1,240 patients (58.1% men, mean age 64±17 years), 103 (8.3%) patients had PE confirmed by CTPA. The ICU transfer and mechanical ventilation were significantly higher in the PE group (for both p&lt;0.001). In an univariable analysis, traditional venous thromboembolic risk factors were not associated with PE (p&gt;0.05), while patients under therapeutic-dose anticoagulation before hospitalisation or prophylaxis-dose anticoagulation introduced during hospitalisation had lower PE occurrence (OR 0.40, 95%CI(0.14-0.91); p=0.04 and OR 0.11, 95%CI(0.06-0.18); p&lt;0.001, respectively). In a multivariable analysis, the following variables, also statistically significant in univariable analysis, were associated with PE: male gender (OR 1.03, 95%CI(1.003-1.069); p=0.04), anticoagulation with prophylaxis-dose (OR 0.83, 95%CI(0.79-0.85), p&lt;0.001) or therapeutic-dose (OR 0.87, 95%CI(0.82-0.92), p&lt;0.001), C-reactive protein (OR 1.03, 95%CI(1.01-1.04), p=0.001) and time from symptom onset to hospitalisation (OR 1.02, 95%CI(1.006-1.038), p=0.002). Conclusions: Pulmonary embolism risk factors in Covid-19 context do not include traditional thromboembolic risk factors but rather independent clinical and biological findings at admission, including a major contribution to inflammation.
Abstract 13494: Lncrna Khps1 Regulates Hif-1a-dependent Pulmonary Vascular Remodeling by Targeting Mir-1, Sphk1 and S1pr2
Authors: Yang Bai, Angelia Lockett, Marta T Gomes, Nicole Jones, Alan de Brito Carneiro, Yen Chun Lai, Roberto F MacHado
Journal: Circulation (2020)

Rationale: Pulmonary vascular remodeling is common in pulmonary arterial hypertension (PAH) and is associated with increased risk of right ventricular failure and death. We have previously reported that sphingosine kinase 1 (Sphk1), sphingosine 1 phosphate receptor 2 (S1PR2), microRNA-1-3p (miR-1-3p) and hypoxia-inducible factor-1α (HIF-1α) are involved in the regulation of pulmonary vascular remodeling and the development of PAH. Recently, it has been reported that the long noncoding RNA (LncRNA) Khps1 is required for Sphk1 expression and cell proliferation. However, whether Khps1 plays a role in PAH is unclear. Here, we tested the hypothesis that Khps1 has an impact on pulmonary vascular remodeling in PAH by regulating Sphk1/S1PR2/HIF-1α signaling pathway. Methods and Results: Using qRT-PCR, our data showed that Khps1 expression levels were up-regulated in pulmonary artery smooth muscle cells (PASMCs) from PAH patients. Increased Khps1 expression levels were also observed in human PASMCs exposed to hypoxia and in lungs obtained from monocrotaline (MCT)-treated rats or hypoxia exposed mice. Luciferase reporter assays showed that Khps1 expression is dependent on E2F1-mediated promoter activation. In silico analysis and luciferase reporter assays also suggested that Khps1 can directly bind to miR-1-3p, suggesting that Khps1 functions as a competing endogenous RNA. Similar studies also showed that miR-1-3p regulates expression of Sphk1 and S1PR2 by binding to their 3’UTR regions. Concurrent E2F1 overexpression and khps1 silencing resulted in a decrease in Sphk1 and S1PR2 expression levels, reduced HIF-1α stabilization and suppressed PASMCs proliferation. Finally, over expression of Sphk1 increased HIF-1α and that in turn increased E2F1 expression in human PASMCs. Conclusion: These data reveal a novel regulatory loop between E2F1, Khps1, miR-1-3p and Sphk1/S1PR2 in the regulation of PASMC proliferation and pulmonary vascular remodeling in PAH. These data also suggest Khps1 regulates pulmonary vascular remodeling in a HIF-1α-dependent manner through targeting Sphk1 and S1PR2.
Abstract 11864: Mesenchymal Stem Cells at the Time of Bypass Surgery Enhances Mitochondrial Biogenesis in Chronically Ischemic Heart Tissue
Authors: Laura Hocum-Stone, Christin Wright, Edward O Mcfalls, Rosemary F Kelly
Journal: Circulation (2019)

Introduction: The protective role of mesenchymal stem cells (MSC) on mitochondrial function within chronically ischemic heart cells remains unclear. Hypothesis: We hypothesized that the mechanism o...
Abstract 326: Practice Variation in the Transition from Weight-based to Flat Dosing of Epinephrine During Cardiopulmonary Resuscitation in Pediatric Intensive Care Units
Authors: Martha Kienzle, Ryan W Morgan, Maya Dewan, Ken Tegtmeyer, Vijay Srinivasan, Vinay M Nadkarni, Kiran Hebbar, Robert M Sutton, Heather A Wolfe
Journal: Circulation (2020)

Introduction: Pediatric Advanced Life Support (PALS) guidelines include weight-based epinephrine dosing recommendations (0.01 mg/kg with a maximum dose of 1mg), but do not specify the age or weight at which adult (flat) dosing should be provided. Hypothesis: We hypothesized that there would be considerable practice variation in the transition from weight-based to flat dosing of epinephrine in pediatric ICUs (PICUs) and that more providers would prioritize weight than age in making this decision. Methods: We performed an IRB-exempt, multi-institution, internet-based survey. Recipients were U.S. PICU attending physicians (one per institution) involved in resuscitation system oversight. Proportions across categories were compared using Chi-square testing. Results: Of 137 institutions surveyed, 68 (50%) responded. Most responding institutions are children’s hospitals (free-standing or dedicated pediatric hospitals within combined hospitals) (67; 99%) and academic (55; 81%); 41 (60%) have PICU fellowship programs. Thirteen (19%) respondents are PICU medical directors, 16 (24%) are resuscitation committee members and 21 (31%) are PICU attendings with an interest in resuscitation. When choosing between weight-based and flat dosing, a significantly higher proportion of providers consider weight (64/68; 94%) vs. age (23/68; 34%) (p &lt;0.01). Among those using age, there were no significant differences in the proportion of providers transitioning at 12 to &lt;14 years of age (0, 0%), 14 to &lt;16 (4, 17%), 16 to &lt;18 (5, 22%) or ≥18 (6, 26%; p=0.82). Among those prioritizing weight, there was a significant difference between the proportion of providers transitioning at 50 to &lt;60kg (28, 44%), 60 to &lt;80kg (17, 27%), 80 to &lt;100kg (5, 8%) or ≥100kg (8, 13%; p&lt; 0.01). Twenty-nine (43%) institutions use an ideal body weight that is less than the patient’s actual weight when dosing epinephrine in obese patients. Conclusions: There is considerable practice variation in the transition from weight-based to flat epinephrine dosing during CPR in PICUs with most institutions using patient weight. Given the potential for large variation in amount of epinephrine delivered to these patients, prospective study is warranted to inform PALS guidelines.
Abstract 193: Multiple Prior Live Births Are Associated With Cardiac Remodeling and Heart Failure in Women
Authors: Amy Sarma, Samantha Paniagua, Elizabeth Liu, Emily Lau, Martin Larson, Daniel Levy, Bruce M Psaty, Norrina B Allen, Vasan S Ramachandran, John S Gottdiener, Sanjiv J Shah, Susan Cheng, Jennifer E Ho
Journal: Circulation (2020)

Introduction: Greater parity has been associated with increased risk of cardiovascular disease, though effects on cardiac remodeling and heart failure risk remain unclear. Hypothesis: We hypothesized that multiple prior live births are associated with (1) structural and functional cardiac remodeling and (2) risk of future heart failure. Methods: We examined the association of number of live births and echocardiographic measures of cardiac structure and function in women participants of the Framingham Heart Study (FHS) using multivariable linear regression. We next examined the association of parity with incident heart failure (HFpEF, HFrEF) using Cox models in a pooled analysis of n=10,431 participants of FHS, the Cardiovascular Health Study, and the Multi-Ethnic Study of Atherosclerosis. Results: Among n=3931 FHS participants (mean age 48 ± 13 years), higher number of live births was associated with worse LV fractional shortening (multivariable β -1.11 (0.31), p= 0.0005 in ≥ 5 live births vs nulliparous women, p trend= 0.02, Figure ). In addition, greater parity was associated with worse cardiac mechanics including global circumferential strain and longitudinal and radial dyssynchrony (p&lt; 0.01 for all comparing ≥ 5 live births vs nulliparity). Over a mean follow-up of 11.7 ± 3.2 years, 298 HFpEF and 225 HFrEF events occurred. Women with ≥5 live births were at higher risk of developing future HFrEF compared with nulliparous women (HR 1.93, 95% CI 1.19-3.12, p=0.008); by contrast, a lower risk of HFpEF was observed (HR 0.58, 95% CI 0.37-0.91, p=0.02, p trend= 0.04). Conclusions: Greater number of live births are associated with worse cardiac structure and function, as well as increased risk of incident HFrEF. Further studies are needed to better understand mechanisms by which repeated pregnancies portend adverse cardiovascular risk.