tbuckley/cabot-search huggingface dataset:
Abstract 174: Regulation of Kv11.1 C-terminal Isoform Expression by Polypyrimidine Tract Binding Protein
Authors: Qiuming Gong, Anastasiya Goldys, Zhengfeng Zhou
Journal: Circulation Research (2017)

The KCNH2 gene encodes the Kv11.1 potassium channel that conducts the rapidly activating delayed rectifier current in the heart. KCNH2 pre-mRNA undergoes alternative processing. Intron 9 splicing leads to the formation of a functional, full-length Kv11.1a isoform, and polyadenylation within intron 9 generates a non-functional, C-terminally truncated Kv11.1a-USO isoform. In this study we investigated the developmental regulation of Kv11.1 isoform expression. We showed that Kv11.1a expression was lower than that of Kv11.1a-USO in the adult heart, but the levels of Kv11.1a and Kv11.1a-USO were similar in the fetal heart. We studied the effect of polypyrimidine tract binding protein (PTB) on the alternative processing of KCNH2 pre-mRNA. PTB is an RNA-binding protein well known for its role in the regulation of alternative splicing. Recently, PTB has been shown to regulate polyadenylation. We showed that PTB increased Kv11.1a isoform expression and decreased Kv11.1a-USO isoform expression by the RNase protection assay and immunoblot analysis. In patch-clamp experiments, we found that PTB significantly increased Kv11.1 current. Our findings suggest that the relative expression of Kv11.1 C-terminal isoforms can be regulated by PTB. It has been reported that PTB protein abundance is progressively reduced during postnatal heart development. Thus, PTB may play an important role in developmental regulation of Kv11.1 isoform expression in the heart.
Clinical manifestations of vaginal trichomoniasis
Authors: P. Wolner-Hanssen
Journal: JAMA (1989)

<i>Trichomonas vaginalis</i>was detected by culture or wet-mount examination in 118 (15%) of 779 randomly selected women attending a sexually transmitted disease clinic. Vaginal trichomoniasis was significantly associated with symptoms of yellow discharge, abnormal vaginal odor, and vulvar itching and with signs of colpitis macularis ("strawberry cervix"), purulent vaginal discharge, and vaginal and vulvar erythema. A logistic regression model was used to adjust for coinfections, as well as for demographic, behavioral, and other possible confounding variables.<i>Trichomonas vaginalis</i>remained significantly associated with symptoms of yellow vaginal discharge (odds ratio [OR] = 2.4) and vulvar itching (OR = 3.0) and with signs of colpitis macularis (OR = 241), purulent vaginal discharge (OR = 8.0), vulvar erythema (OR = 2.5), and vaginal erythema (OR = 4.3). The sensitivity of symptoms and signs associated with trichomoniasis was relatively low. Nevertheless, clinical manifestations can be used to identify those patients for whom a wet-mount examination would likely have high yield. Careful clinical examination and selective use of wet-mount examination together with wider use of more sensitive tests for subclinical infection, such as culture or direct immunofluorescent staining of vaginal fluid, could lead to improved detection and control of this infection. (<i>JAMA</i>1989;261:571-576)
Abstract 159: Epinephrine Increases Cerebral Perfusion and Oxygenation in a Pre-Clinical Model of Pediatric In-Hospital Cardiac Arrest
Authors: Constantine D Mavroudis, Tiffany S Ko, Ryan W Morgan, Marco M Hefti, William P Landis, Timothy W Boorady, Alexandra M Marquez, Michael Karlsson, Daniel J Licht, Vinay M Nadkarni, Robert A Berg, Robert M Sutton, Todd J Kilbaugh
Journal: Circulation (2018)

Introduction: Despite controversies, epinephrine remains a mainstay of CPR. Recent animal studies have suggested that epinephrine may decrease cerebral blood flow (CBF) and cerebral oxygenation, possibly potentiating neurological injury during CPR. We investigated the cerebrovascular effects of intravenous epinephrine in a swine model of pediatric in-hospital cardiac arrest. Hypothesis: Epinephrine will increase CBF and cerebral oxygenation during CPR. Methods: One-month old piglets (n=20, 8-10kg) underwent asphyxia for 7 minutes, VF, and CPR according to AHA guidelines for 10-20 minutes. Epinephrine boluses (20 mcg/kg) were administered at minutes 2, 6, 10, and 14 of CPR. Invasive (laser Doppler) and noninvasive (diffuse optical) continuous measurements of CBF and oxygenation were recorded. Wilcoxon Rank-Sum test was used to compare measurements 15 seconds prior to epinephrine doses to sequential measurements at 1-minute intervals following epinephrine; data are described as median [IQR]. Results: Compared to pre-epinephrine values, CBF was most significantly increased one minute after the first dose of epinephrine (noninvasive: +37.7% [6.1, 79]; invasive: +24% [-0.3, 118], p&lt;0.004 for both) and returned to baseline by 3 minutes post-epinephrine. Cerebral tissue oxygenation was also most significantly increased one-minute after the first dose of epinephrine (noninvasive: +25.2% [9.0, 45]; invasive: +160% [30.3, 428], p&lt;0.001 for both) and remained elevated 4 minutes post-epinephrine. Effects were also significant one minute following the second dose on CBF (noninvasive: +11.5% [4.5, 29]; invasive: +9.5% [0.6, 19, p&lt;0.03 for both) and on cerebral tissue oxygenation (noninvasive: +12.3% [1.6, 19]; invasive: +17.8% [-2.3,34, p&lt;0.037 for both). There was no significant effect on any parameter following the third and fourth doses. Conclusions: In a swine model of pediatric in-hospital cardiac arrest, bolus-dosed epinephrine increases CBF and cerebral tissue oxygen saturation. These effects are only significant following the first two doses. Our findings are underscore the importance of further research to elucidate the transient pharmacodynamics of epinephrine to optimize both survival and neurological outcomes.
AMA RECOGNITION FOR THE PHYSICIAN-STUDENT
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The CD6/ALCAM pathway promotes lupus nephritis via T cell–mediated responses
Authors: Samantha A. Chalmers, Rajalakshmy Ayilam Ramachandran, Sayra J. Garcia, Evan Der, Leal Herlitz, Jeanette Ampudia, Dalena Chu, Nicole Jordan, Ting Zhang, Ioannis Parodis, Iva Gunnarsson, Huihua Ding, Nan Shen, Michelle Petri, Chi Chiu Mok, Ramesh Saxena, Krishna R. Polu, Stephen Connelly, Cherie T. Ng, Chandra Mohan, Chaim Putterman
Journal: Journal of Clinical Investigation (2022)

T cells are central to the pathogenesis of lupus nephritis (LN), a common complication of systemic lupus erythematosus (SLE). CD6 and its ligand, activated leukocyte cell adhesion molecule (ALCAM), are involved in T cell activation and trafficking. Previously, we showed that soluble ALCAM is increased in urine (uALCAM) of patients with LN, suggesting that this pathway contributes to disease. To investigate, uALCAM was examined in 1038 patients with SLE and LN from 5 ethnically diverse cohorts; CD6 and ALCAM expression was assessed in LN kidney cells; and disease contribution was tested via antibody blockade of CD6 in murine models of SLE and acute glomerulonephritis. Extended cohort analysis offered resounding validation of uALCAM as a biomarker that distinguishes active renal involvement in SLE, irrespective of ethnicity. ALCAM was expressed by renal structural cells whereas CD6 expression was exclusive to T cells, with elevated numbers of CD6+ and ALCAM+ cells in patients with LN. CD6 blockade in models of spontaneous lupus and immune-complex glomerulonephritis revealed significant decreases in immune cells, inflammatory markers, and disease measures. Our data demonstrate the contribution of the CD6/ALCAM pathway to LN and SLE, supporting its use as a disease biomarker and therapeutic target.
Acute Disseminated Encephalomyelitis in FET PET/MR
Authors: Niklas Lohaus, Cäcilia Mader, Ilijas Jelcic, Regina Reimann, Martin W. Huellner
Journal: Clinical Nuclear Medicine (2021)

After 3 weeks of daily headache, a 28-year-old, otherwise healthy woman was admitted to the emergency department with a first-time generalized seizure. CT showed a left frontal mass with perifocal edema. Brain MRI raised the suspicion of cerebral lymphoma. Cerebrospinal fluid analysis revealed mononuclear pleocytosis of 14 cells/μL without malignant cells, normal protein levels, and absence of oligoclonal bands. FET PET/MRI of the lesion showed FET characteristics of inflammatory disease, and acute disseminated encephalomyelitis was suggested as diagnosis. Final histopathological results from brain biopsy confirmed acute disseminated encephalomyelitis.
P-161 The diagnostic methods for detection of Helicobacter pylori infection: A comparative approach to invasive methods
Authors: F. Castro-Valencia, A. Guevara-Tique, J. Suarez Olaya, A. Herrera Medina, P. Bedoya Trujillo, G. Parra Gil, L. Carvajal Carmona, M. Echeverry de Polanco, M. Bohorquez Lozano
Journal: Annals of Oncology (2021)
Correction: Thyrotropin aggravates atherosclerosis by promoting macrophage inflammation in plaques
Authors: Chongbo Yang, Ming Lu, Wenbin Chen, Zhao He, Xu Hou, Mei Feng, Hongjia Zhang, Tao Bo, Xiaoming Zhou, Yong Yu, Haiqing Zhang, Meng Zhao, Laicheng Wang, Chunxiao Yu, Ling Gao, Wenjian Jiang, Qunye Zhang, Jiajun Zhao
Journal: The Journal of Experimental Medicine (2022)
Abstract P320: Optimism and Cardiovascular Health Among African Americans in the Jackson Heart Study
Authors: Mario Sims, LáShauntá Glover, Arnita Norwood, Christina Jordan, Yuan-I Min, LaPrincess Brewer, Laura Kubzansky
Journal: Circulation (2018)

Introduction: Compared to other racial and ethnic groups, African Americans experience greater negative psychosocial factors (depression, stress), which are related to increased risk of cardiovascular disease (CVD). Little research has examined the association of positive psychosocial factors (optimism) with cardiovascular health in this population. Using the Jackson Heart Study (JHS) data, we examined the association of optimism with the American Heart Association Life’s Simple 7 TM (LS7), a measure of seven metrics that assesses a person’s cardiovascular health. Hypothesis: Higher levels of optimism are positively associated with individual LS7 metrics, and positively associated with the total LS7 score. Methods: We evaluated cross-sectional associations of optimism with each LS7 metric [cigarette smoking, physical activity, diet, body mass index (BMI), blood pressure, cholesterol, glucose] and with a composite LS7 score among 4,761 participants, 21-95 years old (women=3,070; men=1,691) enrolled in the JHS, a single-site, community-based cohort of African Americans residing in Jackson, MS. Optimism was measured in tertiles (low, moderate, high) to examine threshold effects. Each LS7 metric was classified as poor, intermediate, and ideal. LS7 metrics were also summed to create a total continuous score (0-13) categorized in tertiles (low, moderate, high). Multinomial logistic regression estimated the odds ratios (OR, 95% confidence interval-CI) of intermediate (vs. poor) and ideal (vs. poor) LS7 metric by levels of optimism. Multinomial regression also estimated the odds of moderate (vs. low) or high (vs. low) total LS7 score by optimism. Models adjusted for demographics, SES, and depressive symptoms. Results: Descriptive findings showed that participants who reported high optimism had ideal physical activity, nutrition, smoking, blood pressure, glucose and high total LS7 score (all p&lt;0.01). After adjustment for age, sex, education, income, marital status, and insurance status, participants who reported high (vs. low) optimism had a 39% increased odds of having ideal (vs. poor) physical activity (OR 1.39; 95% CI 1.10-1.76) and a 33% increased odds of having ideal (vs. poor) smoking (OR 1.33; 95% CI 1.02-1.73). Participants who reported high (vs. low) optimism had a 34% greater odds of having a high (vs. low) total LS7 score (OR 1.34 95% CI 1.03-1.74) after full adjustment. Conclusion: Optimism is associated with ideal physical activity and ideal smoking, which is important for promoting cardiovascular health and reducing the risk of CVD among African Americans in this sample.
PERIARTERITIS NODOSA
Journal: Annals of Internal Medicine (1936)

Case Reports1 July 1936PERIARTERITIS NODOSAFREDERICK R. LUMMIS, M.D., F.A.C.P.FREDERICK R. LUMMIS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-1-105 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAs long as the exact status of periarteritis nodosa remains undetermined it will continue to hold the attention of the profession, as it has since the first description approximately 70 years ago. Many cases have been reported in excellent detail, the pathological picture well defined, the experience of the workers abroad and on this continent completely summarized. Bacteriological studies and animal inoculations have not given uniform results. Lately the clinical side has received a major emphasis in the attempt to formulate a picture more easily recognized during life and, perhaps, at an earlier stage of the disease.Of uncertain etiology,...References1. OPHÜLS W: Periarteritis acuta nodosa, Arch. Int. Med., 1923, xxxii, 870-898. CrossrefGoogle Scholar2. FRIEDBERGGROSS CKL: Periarteritis nodosa (necrotizing arteritis) associated with rheumatic heart disease, Arch. Int. Med., 1934, liv, 170-198. CrossrefGoogle Scholar3. MIDDLETONMCCARTER WSJC: The diagnosis of periarteritis nodosa, Am. Jr. Med. Sci., 1935, cxc, 291-308. CrossrefGoogle Scholar4. SCHLESINGERSIGNEYAMIESBARNARD BACRJE: Aetiology of acute rheumatism, Lancet, 1935, ccxxviii, 1145-1149. CrossrefGoogle Scholar5. SWIFTDERICKHITCHCOCK HFCLCH: Bacterial allergy (hyperergy) to non-hemolytic streptococci, Jr. Am. Med. Assoc., 1928, xc, 906-908. CrossrefGoogle Scholar6. MALLORY TB: Case 21461, N. Eng. Jr. Med., 1935, ccxiii, 987. Google Scholar7. KLOTZ O: Periarteritis nodosa, Jr. Med. Res., 1917, xxxvii, 1-50. Google Scholar8. LAMB AR: Periarteritis nodosa, Arch. Int. Med., 1914, xiv, 481-516. CrossrefGoogle Scholar9. BERNSTEIN A: Periarteritis nodosa without peripheral nodules diagnosed antemortem, Am. Jr. Med. Sci., 1935, cxc, 317-325. CrossrefGoogle Scholar10. ARKIN A: A clinical and pathological study of periarteritis nodosa, Am. Jr. Path., 1930, vi, 401-426. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Houston, Texas*Received for publication December 23, 1935. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byKrankheiten der Gefäße 1 July 1936Volume 10, Issue 1Page: 105-116KeywordsEtiologyInoculation ePublished: 1 December 2008 Issue Published: 1 July 1936 PDF downloadLoading ...
Grundlagen der orthodiagraphischen Herzgrössen- und Thoraxbreitenbeurteilung im Kindesalter.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Policy Actions Taken by the House of Delegates on RPS Resolutions
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cholesterol-lowering medication, cholesterol level, and reproductive hormone levels in women: The NHLBI-sponsored WISE study C. N. Bairey Merz, Marian B. Olson, B. D. Johnson, Vera Bittner, T. K. Hodgson, Sarah L. Berga, Glenn D. Braunstein, Sheryl F. Kelsey, George Spoko. Cedars-Sinai Medical Center, Los Angeles, University of Pittsburgh, Pittsburgh
Journal: Journal of the American College of Cardiology (2001)
In patients with unstable angina high levels of C-reactive protein are associated with irregular plaques in carotid arteries: A sign of a diffuse, systemic inflammatory involvement? Pasquale Silvestri, Luigi M. Biasucci, Giovanna Liuzzo, Attilio Maseri, Antonella Lombardo. Catholic University, Rome, Italy
Journal: Journal of the American College of Cardiology (2001)
BELGIUM
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparative outcomes of minimally invasive and open gastrectomy.
Authors: Jamie Glasser, Cassandra Schuster, Jamie Huston, Ravi Shridhar, Kenneth Lee Meredith
Journal: Journal of Clinical Oncology (2022)

271 Background: Gastric cancer(GC) is associated with significant mortality worldwide. Radical gastrectomy with lymphadenectomy is considered the only curative option for GC. Laparoscopic(LG) and more recently robotic(RG) techniques have been developed as a way to potentially decrease the peri-operative morbidity associated with gastrectomy. We sought to compare oncologic outcomes with minimally invasive and open techniques for gastrectomy. Methods: Utilizing the National Cancer Database we identified patients with gastric cancer who underwent gastrectomy. We then stratified technique, RG, LG, or OG. Mann-Whitney U and Kruskal were used to compare continuous variables and Pearson’s Chi-square test was used to compare categorical variables. Unadjusted survival analyses were performed using the Kaplan-Meier method. Multivariate analysis (MVA) was performed to identify predictors of survival. A p &lt; 0.05 was considered significant. Results: We identified 2,530 patients RG, 10,790 in the LG and 25,810 in the OG group with median ages of 66, 66 and 67 years respectively, p &lt; 0.001. There were higher numbers of poorly differentiated tumors in the OG 60% compared to RG (49.7% and LG 49.1%, p &lt; 0.001. Additionally, there were increased numbers of signet ring GC in the OG 16.7%, compared to 13.8% in the RG and 13.8% in the LG, p &lt; 0.001. There were higher numbers of early stage GC’s in the RG and LG compared to more advanced stages (stage II and III in the OG), p &lt; 0.001. RG and LG did demonstrate higher numbers of R0 resections 92.8% and 89.9% compared to OG at 85.2%, p &lt; 0.001. Length of stay was shorter in the RG and LG at 7 (4-10) days compared to 8 days (6-12) in the OG cohort, p &lt; 0.001. Thirty and 90-day mortality rates were higher in the OG (4.3% and 8.3%) compared to 2.1% and 4% in the RG and 2.7% and 5.4% in the LG patients. Median and 5-year survival was higher in the RG (84.7mo and 61%) and LG (90.3mo and 58%) compared to the OG at 48.3mo and 46%, p = 0.001. When adjusted by stage this survival benefit persisted across all stage cohorts (stage 0-1, p = 0.001, stage 2, p = 0.001, and stage 3, p = 0.001). Multivariate analysis revealed that age, sex, Charlson/Deyo score, tumor location, histology, grade, stage, facility volume, and neoadjuvant therapy were all predictors of survival. Conclusions: Robotic and laparoscopic approaches to gastrectomy demonstrate improved median and overall survival compared to conventional open approaches. This benefit was demonstrated across all stages.