tbuckley/cabot-search huggingface dataset:
Apolipoprotein B retention in the grossly normal and atherosclerotic human aorta.
Authors: H FHoff, C LHeideman, A MGotto, J WGaubatz
Journal: Circulation Research (1977)

Apoliporotein B (apoB) was measured in buffer-extracted homogenates of grossly normal and artherosclerotic human aortic intima by means of an electroimmunoassay procedure. The apoB values which were expressed as microgram per mg tissue dry weight, varied widely, ranging from 0.34 to 18.45 in normal intima and from 0.8 to 12.5 in fatty fibrous plaques. No consistent differences in apoB content were found between normal intimas from thoracic and abdominal aortic regions. There was a statistically significant positive correlation between the quantity of buffer-extractable apoB in normal regions and the plasma cholesterol and triglyceride concentration. Buffer-extractable apoB values were significantly higher in fatty fibrous plaques than in ulcerated lesions from the same vessel. However, fatty fibrous plaque apoB values were significantly lower than those from grossly normal regions from the same aorta, although the topographical distribution of apoB was more widespread in plaques than in normal regions, as...
Role of thyroid hormone in regulation of isomyosin composition, contractility, and size of heterotopically isotransplanted rat heart.
Authors: BKorecky, RZak, KSchwartz, VAschenbrenner
Journal: Circulation Research (1987)

The role of thyroid hormone on the heart in terms of contractility, induction of growth, and selective synthesis of cardiac isomyosins was studied. After transplanting rat hearts from inbred hypothyroid donors into the abdomen of hypothyroid recipients of the same strain, two hearts were obtained in the same animal, both having reduced heart rate (200-250 bpm), decreased maximum rate of force, and high predominance of V3 isomyosin. The heart in situ carried a full load, while the transplant was denervated, beat isovolumically with minimum external work. After surgery, the recipient rats were put either on normal diet only (controls) or injected with a daily dose of T3 (average 200 micrograms/kg), which increased the heart rate to 340 bpm in 3 days (euthyroid level) and to 450 bpm in 7 days (hyperthyroid level). In T3-treated rats, the contractility of both hearts normalized in 7 days and showed hyperthyroid pattern in 14 days, while the mass of the in situ hearts increased to normal values in 7 days (+130...
Authors, Readers, and Editors—Dreams of Medical Writing
Authors: J. R. E.
Journal: Annals of Internal Medicine (1963)

Editorials1 September 1963Authors, Readers, and Editors—Dreams of Medical WritingJ. R. E.J. R. E.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-3-410 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBetween each would-be author and his hoped-for reader stands an editor. His is the job to distinguish, in the flow of words, the worthwhile message and to help to get it through to the reader—loud and clear. But occasionally the editor detects, in the static, messages directed, not to the reader, but to himself. They are usually messages of complaint and are cause for wistful if not rueful cogitation in those few moments of calm that sometimes come his way. And he may dream—even as the author and the reader may dream—of medical writing, not as it is, but as...References1. In England now. A running commentary by peripatetic correspondents. Lancet 1: 800, April 14, 1962. Google Scholar2. TALBOTT JH: From one editor to another—a prediction for William B. Bean. Arch. Int. Med. 109: 4, 1962. Google Scholar3. THURBER J: The secret life of Walter Mitty. The Thurber Carnival, Harper and Row, New York, p. 47. Google Scholar4. GARLAND J: The joys and rewards of an editor. Bull. Am. Med. Writers Assoc. 12: 47, 1962. Google Scholar5. QUILLER-COUCH A: On the Art of Writing, Cambridge University Press, Cambridge, England, 1916. Google Scholar6. STRUNKWHITE WEB: The Elements of Style, Macmillan Co., New York, 1959. Google Scholar7. BEAN WB: The art and craft of presenting scientific material. A.M.A. Arch. Int. Med. 100: 513, 1957. CrossrefGoogle Scholar8. QUINCE P: How to write an article. Perspect. in Biol. and Med. 2: 221, 1959. CrossrefMedlineGoogle Scholar9. FLESCH R: The Art of Readable Writing, Harper and Brothers, New York, 1949; Collier Books, New York, 1962. [Provides, for the mathematically minded, a readability formula for calculation of a "human interest" score and a "reading ease" score. The latter = 206.855 - [(ave. sentence length × 1.015) + (no. syllables per 100 words × 0.846)]; on a scale of 0 to 100, less than 50 is difficult reading, greater than 70 is easy reading. The score for this editorial is 52; clearly, for most of us the spirit is willing but the flesh is weak.) Google Scholar10. THOREAU HD: Walden, Ch. 18. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAuthors, Readers, and Editors—A PostscriptA. GORMAN HILLS, M.D. 1 September 1963Volume 59, Issue 3Page: 410-412 ePublished: 1 December 2008 Issue Published: 1 September 1963 PDF downloadLoading ...
Rapid turnover of the AMP-adenosine metabolic cycle in the guinea pig heart.
Authors: KKroll, U KDecking, KDreikorn, JSchrader
Journal: Circulation Research (1993)

The intracellular flux rate through adenosine kinase (adenosine-->AMP) in the well-oxygenated heart was investigated, and the relation of the AMP-adenosine metabolic cycle (AMP adenosine) to transmethylation (S-adenosylhomocysteine [SAH]-->adenosine) and coronary flow was determined. Adenosine kinase was blocked in isolated guinea pig hearts by infusion of iodotubercidin in the presence of the adenosine deaminase blocker erythro-9-(2-hydroxy-3-nonyl)adenine (5 mumol/L). Iodotubercidin (1 nmol/L to 4 mumol/L) caused graded increases in venous effluent concentrations of adenosine, from 8 +/- 3 to 145 +/- 32 nmol/L (mean +/- SEM, n = 3), and in coronary flow, which increased to maximal levels. Flow increases were completely abolished by adenosine deaminase (5 to 10 U/mL). Interstitial adenosine concentrations, estimated using a mathematical model, increased from 22 nmol/L during control conditions to 420 nmol/L during maximal vasodilation. The possibility that iodotubercidin caused increased venous adenos...
Prostate cancer and PARP inhibitors: progress and challenges
Authors: Diego Teyssonneau, Henri Margot, Mathilde Cabart, Mylène Anonnay, Paul Sargos, Nam-Son Vuong, Isabelle Soubeyran, Nicolas Sevenet, Guilhem Roubaud
Journal: Journal of Hematology & Oncology (2021)

Despite survival improvements achieved over the last two decades, prostate cancer remains lethal at the metastatic castration-resistant stage (mCRPC) and new therapeutic approaches are needed. Germinal and/or somatic alterations of DNA-damage response pathway genes are found in a substantial number of patients with advanced prostate cancers, mainly of poor prognosis. Such alterations induce a dependency for single strand break reparation through the poly(adenosine diphosphate-ribose) polymerase (PARP) system, providing the rationale to develop PARP inhibitors. In solid tumors, the first demonstration of an improvement in overall survival was provided by olaparib in patients with mCRPC harboring homologous recombination repair deficiencies. Although this represents a major milestone, a number of issues relating to PARP inhibitors remain. This timely review synthesizes and discusses the rationale and development of PARP inhibitors, biomarker-based approaches associated and the future challenges related to their prescription as well as patient pathways.
Facial burns due to fan heater.
Authors: F van Genechten, G Tudor-Williams
Journal: BMJ (1981)

Significance of early postoperative fever in childrenFever is one of the earliest recorded signs of illness and has been a traditional observation in nursing care for centuries.A small rise in body temperature after operation is a well-recognised phenomenon, particularly in children, but its frequency and implication for care have never been assessed. Patients, methods, and resultsWe studied 150 consecutive children (16 girls, 134 boys) undergoing operation for inguinal hernia.Three boys were also circumscised and two children underwent bilateral herniotomy.Age range was 4 months to 11 years (mean age 3-7 years).The procedure was planned on a day-case basis in all but 32 cases, and operations were performed by several different surgeons.All children were admitted on the morning of operation and recovered during the afternoon.During this period routine postoperative nursing observations were made, including at least two temperature record- ings.The children were later seen by a doctor and allowed home at around 6 pm if their condition was found to be satisfactory; if it was not they remained in hospital.Children were visited several times at home by the district nurse and reviewed in hospital at one month by the medical staff.Body temperature above 37°C was often recorded, and the table shows a relation between temperature reached and age.The incidence of fever over 37 5'C fell from 74 %, in those aged under 1 year to 28 % in those over 4 years. Proportion of children wnith fever after operationFever (C) 37-37-5-7-38 No (") of children with fever within 24 hours 83 (55) 71 (47) 33 (22)No ()of children with fever at 6 pm 66 (44) 56 ( 37) 32 (21) Average age (years) 3 1 2 9 1.9
Prospective Observational Study of 1L NER1006 Compared to 2L Polyethylene Glycol in Inpatients and Outpatients
Authors: T Schiefer, M Hollenbach, J Tünnemann, J Feisthammel, T Karlas, B Holler, M Heindl, T Bielow, S Beer, A Böhlig, F van Bömmel, A Hoffmeister
Journal: Endoscopy (2021)

Aims Bowel preparation for colonoscopy by polyethylene glycole (PEG) is effective but requires high-volume intake. Low-volume NER1006 was non-inferior or, at least in part, superior to PEG in prior studies. However, cleansing efficacy has not been analyzed for inpatients and outpatients specifically. Therefore, we performed a monocentric prospective observational study to address this issue.
Sudden death among postoperative patients with tetralogy of Fallot: a follow-up study of 243 patients for an average of twelve years.
Authors: T GQuattlebaum, JVarghese, C ANeill, J SDonahoo
Journal: Circulation (1976)

Two hundred and forty-three patients were evaluated following total correction of tetralogy of Fallot with special emphasis on postoperative conduction disturbances and on the occurrence of sudden death. The average follow-up period was 12 years with a range of 6 1/2 to 16 1/2 years. Sudden death occurred in seven patients. Four deaths were among those with right bundle branch block pattern (RBBB) and three of the four had premature ventricular contractions (PVC) for more than one month postoperatively. PVCs were documented in ten of the 158 patients with RBBB; sudden death occurred in three (30%). Three of the ten (30%) patients with trifascicular block pattern (TB) died suddenly, while no deaths occurred in 24 patients with bifascicular block pattern (BB). Progression of RBBB to BB and TB occurred in 18 patients from one month to seven years postoperatively (58% of BB and 40% of TB). The risk of sudden death in patients with RBBB and PVCs following tetralogy repair is high and warrants consideration of ...
Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal antibody LY-CoV555 and its cocktail with LY-CoV016
Authors: Tyler N. Starr, Allison J. Greaney, Adam S. Dingens, Jesse D. Bloom
Journal: Cell Reports Medicine (2021)

Monoclonal antibodies and antibody cocktails are a promising therapeutic and prophylaxis for coronavirus disease 2019 (COVID-19). However, ongoing evolution of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) can render monoclonal antibodies ineffective. Here, we completely map all of the mutations to the SARS-CoV-2 spike receptor-binding domain (RBD) that escape binding by a leading monoclonal antibody, LY-CoV555, and its cocktail combination with LY-CoV016. Individual mutations that escape binding by each antibody are combined in the circulating B.1.351 and P.1 SARS-CoV-2 lineages (E484K escapes LY-CoV555, K417N/T escapes LY-CoV016). In addition, the L452R mutation in the B.1.429 lineage escapes LY-CoV555. Furthermore, we identify single amino acid changes that escape the combined LY-CoV555+LY-CoV016 cocktail. We suggest that future efforts diversify the epitopes targeted by antibodies and antibody cocktails to make them more resilient to the antigenic evolution of SARS-CoV-2.
Electrode system influence on biphasic waveform defibrillation efficacy in humans.
Authors: G HBardy, CTroutman, GJohnson, RMehra, J EPoole, G LDolack, P JKudenchuk, D MGartman
Journal: Circulation (1991)

BACKGROUNDSeveral clinical studies have demonstrated a general superiority of biphasic waveform defibrillation compared with monophasic waveform defibrillation using epicardial lead systems. To test the breadth of utility of biphasic waveforms in humans, a prospective, randomized evaluation of defibrillation efficacy of monophasic and single capacitor biphasic waveform pulses was performed for two distinct nonthoracotomy lead systems as well as for an epicardial electrode system in 51 cardiac arrest survivors undergoing automatic defibrillator implantation.METHODS AND RESULTSThe configurations tested consisted of a right ventricular-left ventricular (RV-LV) epicardial patch-patch system, an RV catheter-chest patch (CP) nonthoracotomy system, and a coronary sinus (CS) catheter-RV catheter nonthoracotomy system. For each configuration, the defibrillation current and voltage waveforms were recorded via a digital oscilloscope to measure defibrillation threshold voltage, current, resistance, and stored energy....
Gastrostomy “Button” Diameter And Length Variations After Percutaneous Endoscopic Gastrostomy: One Size Does Not Fit All
Authors: V Macedo Silva, M Freitas, R Sousa Magalhães, T Cúrdia Gonçalves, P Boal Carvalho, C Marinho, J Cotter
Journal: Endoscopy (2021)

Aims Percutaneous endoscopic gastrostomy (PEG) is a useful option for long-term enteral nutrition in patients without an efficient oral intake. Low-profile gastrostomy tubes (“buttons”) may afterwards be placed in the stomach through the abdominal wall following maturation of the pre-existing stoma, usually 6-12 months after the initial procedure. Regular button verification is essential, since inadequate sizing may be associated with accidental exteriorization or food leakage through the stoma. We aimed to evaluate gastrostomy button diameter or length variations on the first year after its placement. A secondary outcome was to identify possible factors associated with these variations.
Acetylcholine antagonism of the electrophysiological effects of isoproterenol on canine cardiac Purkinje fibers.
Authors: J CBailey, A MWatanabe, H RBesch, D ALathrop
Journal: Circulation Research (1979)

The purpose of these experiments was to determine whether or not acetylcholine modulated the electrophysiological effects of isoproterenol on canine cardiac Purkinje fibers. Conventional microelectrode techniques were used. Predictably, isoproterenol produced shortening of action potential duration; acetylcholine significantly blunted this effect of isoproterenol. Isoproterenol restored excitability to fibers exposed to 22 mM potassium solutions, and acetylcholine abolished this isoproterenol-restored excitability. Both of these antagonistic effects of acetylcholine were blocked by atropine. Acetylcholine alone did not affect action potential duration in polarized fibers or excitability in potassium-depolarized fibers. Furthermore, acetylcholine had no effect on the decrease in action potential duration induced by premature electrical stimulation or by acetylstrophanthidin administration, or on excitability of fibers exposed to a zero sodium, high calcium superfusant. These data demonstrate a direct cellu...
The capillary transport system for free fatty acids in the heart.
Authors: C AGoresky, WStremmel, C PRose, SGuirguis, A JSchwab, H EDiede, EIbrahim
Journal: Circulation Research (1994)

The nature of the process by which free fatty acids, which are tightly bound to albumin, traverse the endothelium of cardiac capillaries to reach the cardiac muscle cells, so that they are extracted to a net extent of approximately 40%, needs clarification. Previous studies have indicated that a membrane fatty acid-binding protein provides for carrier-mediated uptake of free fatty acids by isolated hepatocytes, cardiomyocytes, and jejunal mucosal cells. A monoclonal monospecific antibody was prepared against purified membrane fatty acid-binding protein from rat liver. Multiple-indicator dilution experiments were carried out in the isolated rat heart with labeled albumin, sucrose, and palmitate in the presence of control perfusate or perfusate containing either specific antibody or comparable nonspecific myeloma cell supernatant (each of the latter containing additional albumin, in identical concentrations). Analysis of the labeled-sucrose curves provided a permeability-surface area product for sucrose to ...
Nicord Single Unit Expanded Umbilical Cord Blood Transplantation: Final Results of a Multicenter Phase I/ II Trial
Authors: Mitchell E. Horwitz, Daniela Cilloni, David Valcarcel, Francesco Frassoni, Jaap Jan Boelens, Madan Jagasia, John E. Wagner, Jurgen Kuball, Liang Piu Koh, Navneet S. Majhail, Patrick J. Stiff, Rabi Hanna, Richard Thomas T. Maziarz, William YK Hwang, Pau Montesinos, Joanne Kurtzberg, Guillermo Sanz
Journal: Blood (2017)
Some Contributions on How to Formulate Drug Policies and Provide Evidence-Based Regulation
Authors: S. Rolles, D. J. Nutt, A. K. Schlag
Journal: The American Journal of Bioethics (2021)

Earp, Lewis, and Hart (2021) make a comprehensive and compelling argument for ending the “war on drugs,” highlighting the importance of both ending the criminalization of people who use drugs, and ...
A Case of Solitary Laryngotracheal Lymphoma Evaluated by 18F-FDG PET/CT
Authors: Qixin Wang, Wenxin Tang, Songsong Yang, Yue Chen
Journal: Clinical Nuclear Medicine (2021)

Solitary non-Hodgkin lymphoma of the trachea is extremely rare. Herein, we reported a case of solitary laryngotracheal lymphoma in a 55-year-old man. He complained of cough, tachypnea, and dyspnea. 18F-FDG PET/CT showed a hypermetabolic lesion in the subglottic larynx and upper cervical trachea. The subsequent histology and immunohistochemistry of the laryngotracheal lesion tissue confirmed the diagnosis of non-Hodgkin lymphoma (mucosa-associated lymphatic tissue lymphoma).
Research related to surgical treatment of aortic and peripheral vascular disease.
Authors: M EDeBakey
Journal: Circulation (1979)

The history of vascular surgery and the developments that made it possible are briefly traced. Approaches to the treatment of arterial lesions are considered in terms of the characteristic anatomic, pathologic and clinical patterns of arteriosclerosis or atherosclerosis, the basic underlying lesion in most aneurysmal and occlusive diseases of the aorta and major arteries. The importance of appreciating the various patterns and rates of progression of atherosclerosis is emphasized.
In vivo 31P nuclear magnetic resonance measurements in canine heart using a catheter-coil.
Authors: H LKantor, R WBriggs, R SBalaban
Journal: Circulation Research (1984)

We have developed a new method of obtaining high resolution 31P nuclear magnetic resonance spectra from canine heart without the need for major surgery. This is done by passing an elliptical nuclear magnetic resonance receiver coil through a peripheral blood vessel into the right or left ventricle. This technique enables spectra to be obtained from a defined region of myocardium in less than 7 minutes (for the right ventricle) with a signal:noise ratio of greater than 9:1. With this catheter-coil, useful cardiac metabolic information will be obtainable, not only from specified regions of the heart, but also from various layers of myocardium.
Endoscopic Ultrasonography-Guided Biliary Intervention Is Safe And Effective In Pre-Comorbid Patients With Moderate/Severe Cholangitis: A Tertiary Care Center Experience
Authors: J Samanta, G Muktesh, J Dhar, BL Bellum, R Agarwala, P Gupta, TD Yadav, V Gupta, SK Sinha, R Kochhar
Journal: Endoscopy (2021)

Aims Although endoscopic retrograde cholangiopancreatography (ERCP) is the first-line approach for endoscopic biliary access, it might fail or might not be feasible. Endoscopic ultrasonography-guided biliary drainage (EUS-BD) is used as a salvage procedure but is fraught with technical hurdles. Data on its safety in patients with comorbidities and cholangitis is limited and is the aim of this study.
Prostaglandins and potassium relaxation in vascular smooth muscle of the rat. The role of Na-K ATPase.
Authors: W ELockette, R CWebb, D FBohr
Journal: Circulation Research (1980)

We explored the hypothesis that postaglandin-induced vasodilation is caused by activation of the electrogenic sodium-potassium pump which results in membrane hyperpolarization and relaxation of vascular smooth muscle. Helical strips of rat tail artery relax in response to potassium after norepinephrine-induced contractions in physiological salt solution containing a low-potassium concentration. The amplitude of this potassium relaxation is used as an index of sodium-potassium ATPase activity. It was observed that PGA1, PGE2, and PGF2alpha (10(-6) g/ml) significantly enhanced the magnitut. PGE2 caused relaxation of contractions induced by either 25 mM KCl or norepinephrine (10(-9) g/ml), and these relaxations were inhibited by 10(-4) M ouabain. Indomethacin (5.3 x 10(-6) g/ml) and meclofenamate (10(-6) g/ml) reduced the magnitude of potassium-induced relaxation by more than 30% of control. PGF2alpha (10(-5) g/ml) reversed the inhibition of potassium relaxation by meclofenamate. These observations suggest t...
Phosphatidylinositol metabolism in hypertrophic rat heart.
Authors: HKawaguchi, HSano, KIizuka, HOkada, TKudo, KKageyama, SMuramoto, TMurakami, HOkamoto, NMochizuki
Journal: Circulation Research (1993)

The accumulation of inositol 1,4,5-trisphosphate (IP3) after hormonal stimulation has a physiological role, possibly by alteration of Ca2+ levels in cardiac myocyte. However, this accumulation has not been studied under pathophysiological conditions. In this report, we examine phosphatidylinositol metabolism during cellular response to norepinephrine in pressure-overloaded hypertrophic rat heart. After stimulation with norepinephrine, the accumulations of IP3 and diacylglyceride significantly increased in isolated myocytes from stroke-prone spontaneously hypertensive rat (SHRSP) heart, indicating phosphatidylinositol-specific phospholipase C activity increased in SHRSP heart cells. Protein kinase C activity was also enhanced in SHRSP, with a marked increase in particulate activity. We determined the intracellular calcium concentration and found it to be higher in SHRSP than in Wistar-Kyoto (WKY) rats at 30-40 weeks of age. Ca2+ influx was also elevated in SHRSP stimulated by norepinephrine. In SHRSP heart...