tbuckley/cabot-search huggingface dataset:
ALL-CAUSE MORTALITY AFTER SUCCESSFUL ENDOSCOPIC ERADICATION THERAPY FOR BARRETT’S RELATED NEOPLASIA IN A NATIONWIDE COHORT OF 1154 PATIENTS
Authors: E.P.D. Verheij, S.N. van Munster, E.A. Nieuwenhuis, C.C. Cotton, B.L.A.M. Weusten, L. Alvarez Herrero, A. Alkhalaf, B.E. Schenk, E.J. Schoon, W. Curvers, A.D. Koch, P.J.F. de Jonge, T.J. Tang, W.B. Nagengast, J. Westerhof, M.H.M.G. Houben, N.J. Shaheen, J.J.G.H.M. Bergman, R.E. Pouw
Journal: Endoscopy (2022)

Aims Follow-up after successful endoscopic eradication therapy (EET) for Barrett’s neoplasia is strict. Post-EET recurrence detection rates per endoscopy are low and follow-up may be too aggressive. Furthermore, data on competing causes of mortality are not considered. We aimed to evaluate all-cause mortality after successful EET.
22P Biobanking in breast cancer: 10 years of practice at the European Institute of Oncology
Authors: G. Viale, G. Bonizzi, M. Capra, L. Zattoni, C. Cassi, G. Taliento, E. Sajjadi, E. Guerini-Rocco, M.A. Colleoni, V. Galimberti, P. Veronesi, G. Curigliano, R. Orecchia, N. Fusco
Journal: Annals of Oncology (2022)
156TiP BRCA-DIRECT: A randomised UK study evaluating a digital pathway for germline genetic testing and non-inferiority of digitally-delivered information in women with breast cancer
Authors: B. Torr, S. Choi, C. Jones, S. Allen, G. Kavanaugh, M. Hamill, K. Monson, S. Machmahon, M. Valgon Petrizan, L.J. Fallowfield, V. Jenkins, A. George, D.G. Evans, A. Gandhi, Z. Kemp, M. Hubank, C. Turnbull
Journal: Annals of Oncology (2022)
SPIRAL MOTORIZED ENTEROSCOPY: A NEW TOOL FOR FOREIGN BODY REMOVAL
Authors: R. Muñoz Pérez, L. Compañy Catalá, F. Ruiz Gómez, A. Rodríguez Angulo, L. Guilabert Sanz, E. Álvarez Arroyo, J. Martínez Sempere, L. Medina Prado, B. Martínez Moreno, C. Mangas Sanjuán, J.R. Aparicio Tormo
Journal: Endoscopy (2022)

A 16-year-old male presented after ingestion of twelve spherical magnets visualized in hypogastrium on X-ray, not found in colonoscopy with ileoscopy.
CLINICAL OUTCOMES FOLLOWING ENDOSCOPIC MANAGEMENT OF ACUTE PANCREATITIS WITH LARGE (&gt;15 CM) WALLED-OFF PANCREATIC NECROSIS: A RETROSPECTIVE, SINGLE TERTIARY CENTER COHORT STUDY
Authors: M. Ebrahim, M.P. Werge, A. Hadi, M. Lahchich, Z.G. Nagras, M.L. Lauritsen, P.N. Schmidt, E.F. Hansen, S. Novovic, J.G. Karstensen
Journal: Endoscopy (2022)

Aims Development of walled-off pancreatic necrosis (WON) is associated with considerable morbidity and mortality. The use of minimally invasive techniques in the treatment of WON is well established, although data on treatment outcomes in large fluid collections are lacking. The aim of this study was to assess the clinical outcomes following treatment with minimally invasive techniques of WON>15 cm at a single tertiary center.
A CASE OF CYSTIC PARADUODENAL PANCREATITIS WITH GASTRIC OUTLET OBSTRUCTION. TECHNICAL PITFALLS IN ENDOSCOPIC ULTRASOUND-GUIDED GASTROENTEROANASTOMOSIS.​​​​​​​​
Authors: C. Binda, G. Marocchi, C. Coluccio, M. Sbrancia, C. Fabbri
Journal: Endoscopy (2022)

Endoscopic ultrasound-guided gastroenteroanastomosis (EUS-GEA) in an 84 years-old man with cystic paraduodenal pancreatitis with gastric outlet obstruction. Jejunal loop filled with saline and methylene blue was punctured with an electrocautery enhanced lumen apposing metal stent (EC-LAMS). A guidewire was inserted through the EC-LAMS to maintain the access into the target loop. Manipulation of the guidewire lead to the displacement of the tip of the EC-LAMS outside the intestinal loop. Using the previous access, EC-LAMS was re-inserted and stent was deployed. Concluding, despite the good technical and clinical success, the use of guidewire in EUS-GEA must be carefully considered.
A COMPARATIVE STUDY OF COLONOSCOPY PREPARATION WITH 1L PEG+ASCORBIC ACID VS SODIUM PICOSULPHATE WITH MAGNESIUM CITRATE IN REAL-LIFE SETTING: EFFECTIVENESS, AND SAFETY
Authors: E. Perez Arellano, M.I. Rodríguez García, A.B. Galera Ródano, Á. Flores, E. de la Morena Madrigal
Journal: Endoscopy (2022)

Aims Preparations based on polyethylene glycol (PEG) and sodium picosulphate with magnesium citrate (SPMC), are first-line options, but comparative data in a real-life setting are lacking. This study aims to compares the effectiveness and safety of low volume 1L PEG+Ascorbic Acid (1L PEG+A) versus SPMC in real-life setting.
POOLING BARRETT’S ESOPHAGUS (BE) SURVEILLANCE ENDOSCOPIES ON DEDICATED BE ENDOSCOPY LISTS IMPROVES ADHERENCE TO THE FOUR-QUADRANT RANDOM (4QR) BIOPSY PROTOCOL
Authors: I. Beaufort, J. Meeuse, P. van de Meeberg, Y. Alderlieste, R. Verbeek, M. Sikkema, B. Scheffer, T. Naber, M. Ledeboer, P. Pullens, W. van de Vrie, M. Willems, R. Lieverse, M. Verhagen, J. Baars, N. van Heel, P. Bos, J. Burger, B. Weusten
Journal: Endoscopy (2022)

Aims For BE patients, guidelines recommend endoscopic surveillance with 4QR biopsies every 2 centimeters of BE length. In clinical practice however, adherence to the 4QR biopsy protocol is low. We wished to investigate whether pooling BE surveillance endoscopies on dedicated endoscopy lists performed by dedicated endoscopists enhances biopsy protocol adherence and subsequently dysplasia detection rates (DDR).
Circadian clocks, cognition, and Alzheimer’s disease: synaptic mechanisms, signaling effectors, and chronotherapeutics
Authors: Kari R. Hoyt, Karl Obrietan
Journal: Molecular Neurodegeneration (2022)

Abstract Modulation of basic biochemical and physiological processes by the circadian timing system is now recognized as a fundamental feature of all mammalian organ systems. Within the central nervous system, these clock-modulating effects are reflected in some of the most complex behavioral states including learning, memory, and mood. How the clock shapes these behavioral processes is only now beginning to be realized. In this review we describe recent findings regarding the complex set of cellular signaling events, including kinase pathways, gene networks, and synaptic circuits that are under the influence of the clock timing system and how this, in turn, shapes cognitive capacity over the circadian cycle. Further, we discuss the functional roles of the master circadian clock located in the suprachiasmatic nucleus, and peripheral oscillator populations within cortical and limbic circuits, in the gating of synaptic plasticity and memory over the circadian cycle. These findings are then used as the basis to discuss the connection between clock dysregulation and cognitive impairments resulting from Alzheimer’s disease (AD). In addition, we discuss the conceptually novel idea that in AD, there is a selective disruption of circadian timing within cortical and limbic circuits, and that it is the disruption/desynchronization of these regions from the phase-entraining effects of the SCN that underlies aspects of the early- and mid-stage cognitive deficits in AD. Further, we discuss the prospect that the disruption of circadian timing in AD could produce a self-reinforcing feedback loop, where disruption of timing accelerates AD pathogenesis (e.g., amyloid deposition, oxidative stress and cell death) that in turn leads to a further disruption of the circadian timing system. Lastly, we address potential therapeutic approaches that could be used to strengthen cellular timing networks and, in turn, how these approaches could be used to improve cognitive capacity in Alzheimer’s patients.
Charge‐Transfer Complex Combining Reduced Cluster with Enhanced Stability for Combined Near‐Infrared II Photothermal Therapy
Authors: Xueping Kong, Yimeng Yang, Guofeng Wan, Qiuyan Chen, Huimei Yu, Bao Li, Lixin Wu
Journal: Advanced Healthcare Materials (2022)

In the search for materials with enhanced near-infrared (NIR) photothermal properties and capability of providing environment-sensitive therapy, a method that combines isolated components into one nanocomposite is developed. The technique simultaneously involves redox, charge-transfer formation, and ionic complexation. During the polyoxophosphomolybdate (PMo) cluster mixing with biosafe chromogen 3,3',5,5'-tetramethylbenzidine (TMB), the reduced state (rPMo) and the oxidized TMB in the state of charge-transfer complex (cTMB) emerge spontaneously. The two reduced and oxidized components with charges form a stable ionic complex that resists physiology, saline, broad pH, and elevated temperature. Both the rPMo and cTMB contribute to the total sustainable photothermal conversion efficiency of 48.4% in the NIR-II region. The ionic complex exhibits biocompatibility in in vitro cell viability evaluation and is demonstrated to enter tumor cells with sustained photothermal property and complexation stability. Due to the local acidity that triggers further interaction among rPMo clusters, a distinct accumulation of the ionic complex at the tumor position is observed after caudal vein injection. Moreover, a remarkable local NIR-II photothermal image appears. The diminishment of tumor in mice with maintained body weight demonstrates the comprehensive effect of this NIR-II photothermal therapeutic material.
SEASONAL IMPACTS ON THE INCIDENCE OF EASOPHAGEAL VARICEAL BLEEDING
Authors: F. Ben Farhat, M. Sabbah, N. Bellil, D. Trad, N. Bibani, D. Gargouri
Journal: Endoscopy (2022)

Aims The impact of low air temperature on esophageal variceal bleeding has yielded conflicting results. We aimed to explore the impact of seasonal variation on the occurrence and prognosis of variceal bleeding.
SELF-EXPANDABLE DUODENAL METAL STENT PLACEMENT FOR PALLIATION OF GASTRIC OUTLET OBSTRUCTION OVER THE PAST 20 YEARS IN A TERTIARY HOSPITAL IN THE NETHERLANDS
Authors: A. Reijm, P. Zellenrath, R. van der Bogt, L. van Driel, P. Siersema, M. Bruno, M. Spaander
Journal: Endoscopy (2022)

Aims Duodenal stent placement is a palliative option for management of gastric outlet obstruction (GOO) symptoms in cancer patients. In the last 20 years management of gastrointestinal cancers has considerably changed. It is unknown if these changes have affected clinical outcome of duodenal stent placement.
PERFORMANCE COMPARISON OF IMPROVED GAN-BASED ENDOSCOPIC ULTRASOUND PANCREATIC SCANNING NAVIGATION SYSTEM
Authors: H. Wu, H. Yu
Journal: Endoscopy (2022)

Aims EUS is considered one of the most sensitive modalities for pancreatic cancer detection. But EUS is highly operator-dependent and the learning curve is steep. In previous study, we constructed a deep learning-based pancreatic scanning navigation system in EUS, which can assist in identifying the standard station of the pancreas. However, the parameter settings of Gain and Contrast of images scanned by different EUS equipments are different. Such a large generalization leads endoscopists or AI systems to have poor accuracy in identification. Generative Adversarial Networks (GAN) has a strong ability to solve image generalization. Therefore, in this study, we intended to use GAN to optimize the EUS image navigation model, and use target and text recognition to identify the Gain and Contrast parameters of the images to achieve the normalization processing of EUS images.
POLYP SIZE BUT NOT HISTOLOGIC TYPE IS ASSOCIATED WITH RISK FOR COLORECTAL CANCER MORTALITY IN A LARGE SCREENING COHORT
Authors: J. Zessner-Spitzenberg, E. Waldmann, L. Jiricka, L.-M. Rockenbauer, A. Hinterberger, B. Majcher, M. Trauner, M. Ferlitsch
Journal: Endoscopy (2022)

Aims Histologic workup and determination of size of colorectal polyps is needed for the assignment to surveillance colonoscopy, however recent guidelines excluded villous components in adenomas as a high-risk feature. We aimed to assess long-term colorectal cancer mortality in a screening cohort of the Austrian colorectal cancer screening program, in patients with removed polyps≤10mm and>10mm as well as histologic types (tubulous, any villous component and serrated).
New Insights Into Sensory Impairment and Dementia Risk
Authors: Nicholas S. Reed, Esther S. Oh
Journal: JAMA Network Open (2022)

Phillip H. Hwang, PhD, MPH; W. T. Longstreth Jr, MD; Stephen M. Thielke, MD; Courtney E. Francis, MD; Marco Carone, PhD; Lewis H. Kuller, MD; Annette L. Fitzpatrick, PhD
ENDOSCOPIC MANAGEMENT OF COLORECTAL ANASTOMOTIC LEAKAGE COMPLICATED WITH PELVIC ABSCESS : ENDOSCOPIC VACUUM THERAPY A NEW STRATEGY ?
Authors: L. Monino, T. Moreels, D. Leonard, A. Kartheuser
Journal: Endoscopy (2022)

A 56-years old woman underwent laparoscopic anterior resection of the rectum with lymph node dissection and colorectal anastomosis for an adenocarcinoma. One month later, she presented an anastomotic leakage complicated with a presacral abscess and a rectovaginal fistula. The collection was drained endoscopically with double pigtail stents associated with placement of an EndoSponge. The endosponge was connected to an external vacuum collector. The EndoSponge was changed every 3 to 4 days. At day 26, the leakage with the collection were also completely closed. Control at 2 months showed a normal colorectal anastomosis without recurrence of pelvic collection or recto-vaginal fistula.
ENDOSCOPIST DIRECTED PROPOFOL SEDATION IN EUS: PREDICTIVE FACTORS OF SEVERE ADVERSE EVENTS
Authors: P. Huelin Álvarez, E. Pijoan Comas, I. Miguel Salas, G. Torres Vicente, M. Alburquerque Miranda, A. Vargas García, M. Figa Francesch, N. Zaragoza Velasco, J.M. Reñé Espinet, F. Gonzalez-Huix Lladó, SEE D Working Group on Sedation
Journal: Endoscopy (2022)

Aims Severe adverse events including hypoventilation and laryngospasm during EUS are frequently related to the wider tip of the echoendoscopes.
1MO Prognostic and biologic significance of HER2-low expression in early breast cancer
Authors: P. Tarantino, Q. Jin, N. Tayob, R. Jeselsohn, S.J. Schnitt, J. Vincuilla, T. Parker, S. Tyekucheva, N.U. Lin, M. Hughes, A.C. Weiss, T.A. King, E.A. Mittendorf, G. Curigliano, S.M. Tolaney
Journal: Annals of Oncology (2022)
27P Association between CD8+ tumor infiltrating lymphocytes and the clinical outcome of patients with operable breast cancer treated with adjuvant dose-dense chemotherapy: A 10-year follow up report of a Hellenic Cooperative Oncology Group observational study
Authors: N. Spathas, A. Goussia, G.A. Koliou, H. Gogas, F. Zagouri, M. Bobos, D.G. Pectasides, E. Galani, A. Koutras, G. Zarkavelis, E. Saloustros, D. Bafaloukos, C. Karanikiotis, G. Aravantinos, A. Psyrri, E. Razis, A. Koumarianou, E. Res, H. Linardou, G. Fountzilas
Journal: Annals of Oncology (2022)
UPPER GASTRO INTESTINAL BLEEDING AND CIRRHOTICS- A SINGLE CENTRE OBSERVATIONAL STUDY FROM SOUTH INDIAN POPULATION
Authors: S. Sebastian, D.J. Susan Roy, D.B. Sebastian, D.S.K Mathai
Journal: Endoscopy (2022)

Aims The etiology of upper gastrointestinal bleed in cirrhotics (UGIB) is variable in different geographical regions .Epidemiological data are helpful in knowing the burden of the problem. This study was conducted to know the spectrum, mortality, morbidity, and predictors of outcome in patients with Cirrhotics presenting with acute UGIB.
Mistreatment Experiences, Protective Workplace Systems, and Occupational Distress in Physicians
Authors: Susannah G. Rowe, Miriam T. Stewart, Sam Van Horne, Cassandra Pierre, Hanhan Wang, Makaila Manukyan, Megan Bair-Merritt, Aviva Lee-Parritz, Mary P. Rowe, Tait Shanafelt, Mickey Trockel
Journal: JAMA Network Open (2022)

Reducing physician occupational distress requires understanding workplace mistreatment, its relationship to occupational well-being, and how mistreatment differentially impacts physicians of diverse identities.To assess the prevalence and sources of mistreatment among physicians and associations between mistreatment, occupational well-being, and physicians' perceptions of protective workplace systems.This survey study was administered in September and October 2020 to physicians at a large academic medical center. Statistical analysis was performed from May 2021 to February 2022.Primary measures were the Professional Fulfillment Index, a measure of intent to leave, and the Mistreatment, Protection, and Respect Measure (MPR). Main outcomes were the prevalence and sources of mistreatment. Secondary outcomes were the associations of mistreatment and perceptions of protective workplace systems with occupational well-being.Of 1909 medical staff invited, 1505 (78.8%) completed the survey. Among respondents, 735 (48.8%) were women, 627 (47.1%) were men, and 143 (9.5%) did not share gender identity or chose "other"; 12 (0.8%) identified as African American or Black, 392 (26%) as Asian, 10 (0.7%) as multiracial, 736 (48.9%) as White, 63 (4.2%) as other, and 292 (19.4%) did not share race or ethnicity. Of the 1397 respondents who answered mistreatment questions, 327 (23.4%) reported experiencing mistreatment in the last 12 months. Patients and visitors were the most common source of mistreatment, reported by 232 physicians (16.6%). Women were more than twice as likely as men to experience mistreatment (31% [224 women] vs 15% [92 men]). On a scale of 0 to 10, mistreatment was associated with a 1.13 point increase in burnout (95% CI, 0.89 to 1.36), a 0.99-point decrease in professional fulfillment (95% CI, -1.24 to -0.73), and 129% higher odds of moderate or greater intent to leave (odds ratio, 2.29; 95% CI, 1.75 to 2.99). When compared with a perception that protective workplace systems are in place "to a very great extent," a perception that there are no protective workplace systems was associated with a 2.41-point increase in burnout (95% CI, 1.80 to 3.02), a 2.81-point lower professional fulfillment score (95% CI, -3.44 to -2.18), and 711% higher odds of intending to leave (odds ratio, 8.11; 95% CI, 3.67 to 18.35).This survey study found that mistreatment was common among physicians, varied by gender, and was associated with occupational distress. Patients and visitors were the most frequent source, and perceptions of protective workplace systems were associated with better occupational well-being. These findings suggest that health care organizations should prioritize reducing workplace mistreatment.
Contribution of Individual- and Neighborhood-Level Social, Demographic, and Health Factors to COVID-19 Hospitalization Outcomes
Authors: Renuka Tipirneni, Monita Karmakar, Megan O’Malley, Hallie C. Prescott, Vineet Chopra
Journal: Annals of Internal Medicine (2022)

Although disparities in COVID-19 outcomes have been observed, factors contributing to these differences are not well understood.To determine whether COVID-19 hospitalization outcomes are related to neighborhood-level social vulnerability, independent of patient-level clinical factors.Pooled cross-sectional study of prospectively collected data.38 Michigan hospitals.Adults older than 18 years hospitalized for COVID-19 in a participating site between March and December 2020.COVID-19 outcomes included acute organ dysfunction, organ failure, invasive mechanical ventilation, intensive care unit stay, death, and discharge disposition. Social vulnerability was measured by the social vulnerability index (SVI), a composite measure of social disadvantage.Compared with patients in low-vulnerability ZIP codes, those living in high-vulnerability ZIP codes were more frequently treated in the intensive care unit (29.0% vs. 24.5%); more frequently received mechanical ventilation (19.3% vs. 14.2%); and experienced higher rates of organ dysfunction (51.9% vs. 48.6%), organ failure (54.7% vs. 51.6%), and in-hospital death (19.4% vs. 16.7%). In mixed-effects regression analyses accounting for age, sex, and comorbid conditions, an increase in a patient's neighborhood SVI by 0.25 (1 quartile) was associated with greater likelihood of mechanical ventilation (increase of 2.1 percentage points), acute organ dysfunction (increase of 2.8 percentage points), and acute organ failure (increase of 2.8 percentage points) but was not associated with intensive care unit stay, mortality, or discharge disposition.Observational data focused on hospitalizations in a single state.Hospitalized patients with COVID-19 from socially vulnerable neighborhoods presented with greater illness severity and required more intensive treatment, but once hospitalized they did not experience differences in hospital mortality or discharge disposition. Policies that target socially vulnerable neighborhoods and access to COVID-19 care may help ameliorate health disparities.Blue Cross Blue Shield of Michigan (BCBSM) and Blue Care Network as part of the BCBSM Value Partnerships Program, the Michigan Public Health Institute, and the Michigan Department of Health & Human Services.
ASSESSMENT OF QUALITY PERFORMANCE MEASURES FOR ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY
Authors: M. Serrano Dueñas, F. Domper Bardají, E. De la Santa Belda, F. Ramírez Esteso, M. Rodríguez González
Journal: Endoscopy (2022)

Methods We performed a prospective registry of ERCP procedures in a tertiary center from October 2020. Included a one-month follow-up for evaluating complications. We present a preliminary analysis of those procedures performed until May 2021. The final number consisted of 170 interventions. We assessed the measures and compared them to the standard proposed by the European Society of Gastrointestinal Endoscopy.
SMALL BOWEL CAPSULE ENDOSCOPY IN OBSCURE GASTROINTESTINAL BLEEDING: A MATCHED COHORT COMPARISON OF PATIENTS WITH NORMAL VS SURGICALLY-ALTERED GASTRIC ANATOMY
Authors: X. Dray, G. Rahmi, M.E. Riccioni, G. Vanbiervliet, G. Wurm Johansson, C. Leandri, P. Baltes, C. Duburque, F. Cholet, A. Koulaouzidis, L. Quénéhervé
Journal: Endoscopy (2022)

Aims Little is known about small bowel capsule endoscopy (SBCE) outcomes in patients with surgically altered anatomy. We aimed to assess the feasibility and diagnostic yield of orally ingested SBCE to investigate obscure gastrointestinal bleeding (OGIB) in patients with surgically altered gastric anatomy, compared to native gastric anatomy.
Prospective Multicenter Study of the Primary Obesity Surgery Endoluminal (POSE 2.0) Procedure for Treatment of Obesity
Authors: Gontrand Lopez Nava, Roman Turro Arau, Ravishankar Asokkumar, Daniel B Maselli, Babusai Rapaka, Reem Matar, Inmaculada Bautista, Jorge Carlos Espinos Perez, Alfredo Mata Bilbao, Veeravich Jaruvongvanich, Eric J Vargas, Andrew C Storm, Manoel Galvao Neto, Barham K Abu Dayyeh
Journal: Clinical Gastroenterology and Hepatology (2022)
Altered glycosylation in pancreatic cancer and beyond
Authors: Jan C. Lumibao, Jacob R. Tremblay, Jasper Hsu, Dannielle D. Engle
Journal: The Journal of Experimental Medicine (2022)

Pancreatic ductal adenocarcinoma (PDA) is one of the deadliest cancers and is projected to soon be the second leading cause of cancer death. Median survival of PDA patients is 6-10 mo, with the majority of diagnoses occurring at later, metastatic stages that are refractory to treatment and accompanied by worsening prognoses. Glycosylation is one of the most common types of post-translational modifications. The complex landscape of glycosylation produces an extensive repertoire of glycan moieties, glycoproteins, and glycolipids, thus adding a dynamic and tunable level of intra- and intercellular signaling regulation. Aberrant glycosylation is a feature of cancer progression and influences a broad range of signaling pathways to promote disease onset and progression. However, despite being so common, the functional consequences of altered glycosylation and their potential as therapeutic targets remain poorly understood and vastly understudied in the context of PDA. In this review, the functionality of glycans as they contribute to hallmarks of PDA are highlighted as active regulators of disease onset, tumor progression, metastatic capability, therapeutic resistance, and remodeling of the tumor immune microenvironment. A deeper understanding of the functional consequences of altered glycosylation will facilitate future hypothesis-driven studies and identify novel therapeutic strategies in PDA.