tbuckley/cabot-search huggingface dataset:
Role of endothelin in the maintenance of blood pressure in conscious rats with chronic heart failure. Acute effects of the endothelin receptor antagonist Ro 47-0203 (bosentan).
Authors: J RTeerlink, B MLöffler, PHess, J PMaire, MClozel, J PClozel
Journal: Circulation (1994)

BACKGROUNDEndothelin (ET) is a potent vasoconstrictor, and its concentration is increased in patients with heart failure. The purpose of this study was to investigate the role of endothelin in heart failure by use of a rat model.METHODS AND RESULTSExperiments were performed on rats at 1 through 16 weeks after sham operation or coronary artery ligation. Rats with left ventricular end-diastolic pressures > 15 mm Hg were considered to have chronic heart failure (CHF), while the others were considered to have uncomplicated myocardial infarction (MI). There were increased ET-1 concentrations in CHF rats at weeks 1 to 16 (Sham, 20 +/- 0.5 pg/mL, n = 45; CHF, 31 +/- 2 pg/mL, n = 50; P < .001) and transient increases in ET-3 concentrations at week 1 in both the MI and CHF groups. There were no significant increases in big ET-1 concentrations, suggesting an increased conversion of ET-1 from big ET-1 in the CHF group. At weeks 2 through 8, oral administration of the mixed (ETA and ETB) endothelin receptor antagonis...
Radionuclide ventriculography for assessment of absolute right and left ventricular volumes in children.
Authors: M DParrish, T PGraham, M LBorn, J PJones, R JBoucek, C LPartain
Journal: Circulation (1982)

We determined absolute right and left ventricular volumes and cardiac output from the equilibrium radionuclide angiogram in 26 children, ages 3 months to 18 years, with diverse types of heart disease. We validated these results by comparing them with left ventricular (20 patients) and right ventricular (16 patients) cineangiographic volumes and cardiac output. Radionuclide volumes and cardiac outputs were determined in two ways: by a geometric method (area-length for left ventricle, Simpson's rule for right ventricle) and by a count-based method (correcting ventricular regional counts for frame duration, acquisition time, venous blood counts and attenuation). Both methods for estimating left ventricular end-diastolic volume compared favorably with cineangiography (correlation coefficients greater than 0.90). The count-based method also correlated well for the right ventricle. End-systolic measurements were not possible. Count-based assessment of cardiac output also correlated well with cineangiographic va...
Determination of Brain Death
Authors: Emily T. Cohen, Robert S. Hoffman
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment for Depression Symptoms in Ugandan Adolescent Survivors of War and Displacement—Reply
Authors: Paul Bolton, Theresa Betancourt, Richard Neugebauer, Liesbeth Speelman
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
一酸化窒素傷害内皮細胞への単球接着においてMCP‐1によるCCR2の活性化はCa2+流を介したTF発現を促進する
Authors: Sakamoto T, Ishibashi T, Sakamoto N, Ohkawara H, Sugimoto K, Kamioka M, Nagata K, Yokoyama K, Maruyama Y
Journal: Circulation (2005)
Usefulness of ERCP Bile Aspirated Culture in Patients With Acute Cholangitis
Authors: C Burciu, I Sporea, I Ratiu, T Moga, F Bende, Ghiuchici AM, R Mare, B Miutescu
Journal: Endoscopy (2021)

Aims Targeted antimicrobial therapy can favour good clinical outcomes and can avoid recurrence of infection and early stent occlusion in patients with acute cholangitis. This study compares the microbial yield of blood cultures and bile aspirate cultures in patients with ascending cholangitis.
Abstract 1026: Oncogenic alterations in FGFR3 and ERBB2 lead to ligand-independent activation of PPARG in bladder cancer
Authors: Jonathan T. Goldstein, Ashton C. Berger, Craig A. Strathdee, Matthew Meyerson
Journal: Cancer Research (2019)

Abstract PPARG is genomically activated in muscle-invasive bladder cancer through focal PPARG gene amplification and hotspot mutations in its heterodimer partner, RXRA. However, more than half of the PPARG-activated bladder tumors and cell lines do not have identifiable somatic alterations in either PPARG or RXRA. Using a PPARG-driven reporter assay in RT112 bladder cancer cell line, we screened probe compounds to identify candidate drivers of ligand-independent PPARG activation. We found that pan-FGFR inhibitors and MEK1/2 inhibitors antagonized the PPARG-driven reporter assay with potency similar to reported values for their cognate targets (1-20 nM) and interestingly, RT112 cells carry an FGFR3-TACC3 oncogenic fusion. In addition to the expected effects of these inhibitors on phospho-MEK1/2 and phospho-ERK1/2, they also inhibited production of canonical PPARG targets, including FABP4. In a second subset of cell lines, a parallel story was also observed for the effects of ERBB2 inhibitors in ERBB2 hotspot mutant bladder cancer. Taken together, these data uncover additional mechanisms for functional activation of PPARG in bladder cancer, suggest potential resistance mechanisms for FGFR and ERBB2 inhibitors, and provide a rationale for therapeutic combinations of PPARG modulators. Citation Format: Jonathan T. Goldstein, Ashton C. Berger, Craig A. Strathdee, Matthew Meyerson. Oncogenic alterations in FGFR3 and ERBB2 lead to ligand-independent activation of PPARG in bladder cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1026.
TCTAP A-033 The Impact of Concomitant Use of Proton Pump Inhibitors and Clopidogrel on Patient Mortality and Outcome Post Angioplasty
Authors: Shaban Mohammed, Abdulrahaman Arabi, Nawel Bensmail, Ahmed Moursi, Mohamed Sharabash, Ayman El-Menyar, Rania Abdel-Latif, Salah Arafa, Ihsan Rafie, Awad Alqahtani, Moza Al Hail, Nidal Asaad, Jassim Al Suwaidi
Journal: Journal of the American College of Cardiology (2021)
The "false negative" treadmill exercise test and left ventricular dysfunction.
Authors: NKramer, ASusmano, R BShekelle
Journal: Circulation (1978)

One hundred and fifteen consecutive symptomatic patients undergoing graded exercise testing, selective coronary angiography and left ventriculography were retrospectively evaluated. The sensitivity, specificity, and false negative response rates of the exercise tests were 79%, 81%, and 21%, respectively. Although the magnitude of a positive ST-segment response was related to more extensive vascular disease, the frequency of false negative responses was nearly identical in patients with single, double, or triple vessel disease (22%, 21%, 19%). Analysis of the false negative group demonstrated significant ventriculographic and hemodynamic abnormalities when compared to the true positive responders. Five out of six patients with the most serious motion disorders in the study fell into the false negative group. There were no significant differences in the extent, distribution and severity of vascular involvement, or in the development of collateral circulation in the two groups. However, occluded vessels supp...
Right ventricular compression as a sign of cardiac tamponade: an analysis of echocardiographic ventricular dimensions and their clinical implications.
Authors: N BSchiller, E HBotvinick
Journal: Circulation (1977)

We have identified pericardial effusion by echocardiography in 174 patients. Seventeen had cardiac tamponade which was not always clinically obvious. Right ventricular narrowing or compression, occurring in the minor axis at end diastole and end expiration, to 7 +/- 2 mm or less, was strongly associated with tamponade in patients with effusion. Right ventricular compression and signs of tamponade abated with pericardiocentesis. One patient was in tamponade without obvious right ventricular narrowing. Nonetheless, he demonstrated serial increases in right ventricular dimensions which paralleled hemodynamic improvement. Diminished left ventricular end-diastolic dimension, swinging heart, electrical alternans, reciprocal respiratory variations in right and left ventricular end-diastolic dimensions and variation in amplitude of the mitral D-E slope were nonspecific for tamponade. Evaluation of right ventricular dimensions may be clinically useful to diagnose and monitor cardiac tamponade.
Travel-associated Legionnaires’ disease in Europe, 2010
Authors: B de Jong, L Payne Hallström, E Robesyn, D Ursut, P Zucs, None on behalf of ELDSNet (European Legi
Journal: Eurosurveillance (2013)

In 2010, the European surveillance network for travel-associated Legionnaires&apos; disease (ELDSNet, previously EWGLINET) received reports of 864 cases of travel-associated Legionnaires&apos; disease, of whom 24 were reported to have had a fatal outcome. As in previous years, a very low proportion of clinical isolates were obtained (45 cases, 5.6%). In the 2010 dataset, male cases outnumbered female cases by 2.6:1 and had a median age of 61 years (range: 21-96), while the median age for women was 63 years (range: 12-95). The network identified 100 new clusters in 2010, of which 44 involved only one case from each reporting country and would probably not have been detected by national surveillance schemes alone. The largest cluster (having 14 cases) was associated with a cruise ship. Legionella species were detected at 61 of the 100 accommodation site clusters investigated. The names of five accommodation sites were published on the ECDC website. .
Shall The Journal be Removed to Washington?
Authors: W. E. Ward
Journal: JAMA (1891)

<h3>To the Editor:</h3> —While there appear so many reasons for keepingThe Journalwhere it is, I oppose the question of removal. It would seem that the facility of distribution which the present location affords should decide the matter if nothing else does. I second Dr. Dimmitt's motion that a vote be taken at an early date. This will give every member a chance to express his opinion. 255 North ave., Chicago, Ill., Jan. 17, 1891.
Comparative vascular pharmacology of the atriopeptins.
Authors: KWakitani, TOshima, A DLoewy, S WHolmberg, B RCole, S PAdams, K FFok, M GCurrie, PNeedleman
Journal: Circulation Research (1985)

The atriopeptins are potent relaxants of norepinephrine-constricted aortic strips or are dilators of renal blood vessels in isolated perfused rat kidneys that are constricted by norepinephrine. This vasorelaxant property of the atriopeptins requires the presence of phenylalanine arginine (i.e., atriopeptin II, III, or ser-leu-arg-arg atriopeptin III) residues in the carboxy terminus which are considerably more effective than atriopeptin I (the 21 amino acid peptide which lacks the phe-arg C-terminus) or the core peptide (residues 3-19). However, these artificially in vitro precontracted preparations do not accurately predict the vascular effectiveness of the atriopeptins in intact rats. Intravenous administration of the atriopeptins (including atriopeptin I) to anesthetized rats produces concentration-dependent hypotension, a selective decrease in renal resistance in low doses (determined with microspheres), and pronounced diuresis. At higher doses, atriopeptins increase blood flow in other vascular beds....
Inhibition of sarcolemmal carbon-centered free radical formation by propranolol.
Authors: I TMak, C MArroyo, W BWeglicki
Journal: Circulation Research (1989)

The mechanism of propranolol-inhibited sarcolemmal membrane lipid peroxidation was investigated by electron spin resonance spin-trapping technique using 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) and 2-methyl-2-nitrosopropane (MNP). Highly purified canine myocytic sarcolemma were peroxidized by a superoxide-driven (from dihydroxyfumarate) and Fe3+-catalyzed free radical-generating system. Hydroxyl radicals (.OH), identified by electron spin resonance signals as DMPO-OH adducts, were generated in the aqueous phase. Propranolol up to 500 microM did not effectively reduce the intensity of the DMPO-OH adducts. When the sarcolemma were incubated with MNP before the addition of free radicals, MNP adducts characteristic of carbon-centered radicals were produced. Pretreatment of the membranes with propranolol (3-100 microM) decreased the intensity of the MNP adducts in a log concentration-dependent manner; the EC50 is about 7 microM. D- and L-propranolol were found equally effective. When protein-depleted sarcolemma...
Echocardiographic follow-up of atrial septal defect after catheter closure by double-umbrella device.
Authors: CBoutin, N NMusewe, J FSmallhorn, J DDyck, TKobayashi, L NBenson
Journal: Circulation (1993)

BACKGROUNDTranscatheter device occlusion of atrial septal defects is an attractive approach, but its efficacy and place in patient management remain to be determined.METHODS AND RESULTSTo evaluate the medium-term results of atrial septal defect device occlusion and factors influencing residual shunting, transesophageal and transthoracic echocardiograms of 49 patients were reviewed. Transesophageal echocardiograms on 48 patients immediately following surgical closure revealed residual shunting in 2% compared with 91% after device occlusion; this proportion decreased to 53% after a mean follow-up of 10 months. The actuarial analysis suggests a progressive resolution of shunting with time. One patient had residual shunting by transesophageal echocardiography immediately after surgical closure compared with 29 after a mean follow-up of 10 months after device occlusion. Residual shunting was not influenced by (1) dimension, location, or position with relation to the device as assessed by transesophageal echoca...
Abstract 15787: Predictors and Site-Level Variation in DNR Status Among Patients Hospitalized With Heart Failure
Authors: Supriya Shore, Donald Likosky, Edo Birati, Keith D Aaronson, Brahmajee K Nallamothu
Journal: Circulation (2019)

Introduction: Contemporary data on resuscitation preferences in heart failure (HF) patients are lacking. We identified predictors of and assessed hospital-level variation in Do Not Resuscitate (DNR...
A force-length-time relationship describes the mechanics of canine left ventricular wall segments during auxotonic contractions.
Authors: HPiene, J WCovell
Journal: Circulation Research (1981)

We examined regional mechanics of the left ventricular free wall in naturally pumping dog hearts during beta-blockade. Local systolic wall force (F) and segment length (L) were obtained with an auxotonic force gauge and an ultrasonic dimension gauge, both inserted at the equatorial level of the wall to measure F and L in the circumferential direction. Shortening velocity (-dL/dt) was obtained by differentiation of L. Preload and afterload were changed by acute caval and/or aortic occlusion so that a wide variation in F, L, -dL/dt, and dF/dt during shortening was obtained. In all experiments, F vs. L at identical time (t) after end-diastole (ED) fell on well-defined lines, irrespective of the -dL/dt line (t = 200 msec) was equivalent to a drop of approximately 50% in F at 10% reduction in L. No defined relationship was observed between F, L, and -dL/dt. However, by superimposing F, L, and -dL/dt curves from contractions of high EDL and high -dL/dt on those from contractions of low EDL and low -dL/dt, and c...
Age and Sex Interactions in Recovery From Mild Traumatic Brain Injury: More Questions Than Answers
Authors: Martina Anto-Ocrah, Rebekah Mannix, Jeffrey J. Bazarian
Journal: JAMA Network Open (2021)

Harvey S. Levin, PhD; Nancy R. Temkin, PhD; Jason Barber, MS; Lindsay D. Nelson, PhD; Claudia Robertson, MD; Jeffrey Brennan, MS; Murray B. Stein, MD, MPH; John K. Yue, MD; Joseph T. Giacino, PhD; Michael A. McCrea, PhD; Ramon Diaz-Arrastia, MD, PhD; Pratik Mukherjee, MD, PhD; David O. Okonkwo, MD, PhD; Kim Boase, BA; Amy J. Markowitz, JD; Yelena Bodien, PhD; Sabrina Taylor, PhD; Mary J. Vassar, RN, MS; Geoffrey T. Manley, MD, PhD; TRACK-TBI Investigators; Opeolu Adeoye, MD; Neeraj Badjatia, MD; M. Ross Bullock, MD, PhD; Randall Chesnut, MD; John D. Corrigan, PhD, ABPP; Karen Crawford, MLIS; Sureyya Dikmen, PhD; Ann-Christine Duhaime, MD; Richard Ellenbogen, MD; V. Ramana Feeser, MD; Adam R. Ferguson, PhD; Brandon Foreman, MD; Raquel Gardner, MD; Etienne Gaudette, PhD; Luis Gonzalez, BA; Shankar Gopinath, MD; Rao Gullapalli, PhD; J. Claude Hemphill, MD; Gillian Hotz, PhD; Sonia Jain, PhD; C. Dirk Keene, MD, PhD; Frederick K. Korley, MD, PhD; Joel Kramer, PsyD; Natalie Kreitzer, MD; Chris Lindsell, PhD; Joan Machamer, MA; Christopher Madden, MD; Alastair Martin, PhD; Thomas McAllister, MD; Randall Merchant, PhD; Amber Nolan, MD, PhD; Laura B. Ngwenya, MD, PhD; Florence Noel, PhD; Eva Palacios, PhD; Ava Puccio, PhD; Miri Rabinowitz, PhD; Jonathan Rosand, MD, MSc; Angelle Sander, PhD; Gabriella Satris, MS; David Schnyer, PhD; Seth Seabury, PhD; Xiaoying Sun, PhD; Arthur Toga, PhD; Alex Valadka, MD; Kevin Wang, PhD; Esther Yuh, MD, PhD; Ross Zafonte, DO
The Acute Effect of Biological Agents used in Inflammatory Bowel Disease on ECG Parameters
Authors: B Çavuş, A Çiftcibaşı Örmeci, D Kaya, N Alizade, A Yakut, Z İmanov, Şenkal İV, E Çevik, A Atıcı, K Demir, F Beşışık, S Kaymakoğlu, F Akyuz
Journal: Endoscopy (2021)

Aims Ulcerative colitis and Crohn’s disease are chronic inflammatory bowel diseases.The effect of inflammation on atrial and ventricular conduction defects is known,however,different results have been obtained in many studies on the effectiveness of anti TNFs and biological agents on cardiac conduction. We aimed to evaluate the effects of biological agents on atrial and ventricular conduction in IBD through ECG parameters.
Impaired cardiopulmonary baroreflex control of renal nerves in renal hypertension.
Authors: M DThames, L NJohnson
Journal: Circulation Research (1985)

We recently reported that arterial baroreflex control of renal nerve traffic is impaired in renal hypertensive rabbits. The purpose of this study was to determine if vagal cardiopulmonary baroreflex control of renal nerve traffic is also impaired. Experiments were performed in 10 hypertensive (mean arterial pressure +/- SE in conscious state, 110 +/- 3 mm Hg) and 10 normotensive (79 +/- 1 mm Hg) chloralose-anesthetized rabbits. Responses to graded blood volume expansion (+5, +10, +15 ml/kg) with dextran in saline were recorded with all baroreflexes intact, after sinoaortic baroreceptor denervation, and after vagotomy. With arterial and cardiopulmonary baroreflexes intact, volume expansion resulted in decreases in renal nerve traffic of -12 +/- 2%/mm Hg increase in left atrial pressure in normotensive rabbits, but of only -5 +/- 2%/mm Hg in the hypertensive rabbits (P less than 0.05). This difference is particularly striking in view of the larger maximum increases in arterial (25 +/- 7 vs. 12 +/- 3 mm Hg) ...
Vasopressin and the mature coronary collateral circulation.
Authors: K GPeters, M LMarcus, D GHarrison
Journal: Circulation (1989)

In isolated vascular rings, we have shown that mature coronary collateral vessels are highly responsive to the vasoconstrictor effects of vasopressin. The purpose of the present study was to determine the effect of concentrations of vasopressin encountered in pathophysiologic states on the collateral circulation in vivo. We studied eight open-chest anesthetized dogs with mature coronary collateral vessels 3-6 months after placement of an ameroid constrictor on the left circumflex coronary artery. The left anterior descending coronary artery was perfused at constant pressure, and peripheral coronary pressure was monitored continuously throughout each experiment. At baseline and during intracoronary infusion of vasopressin, which resulted in concentrations ranging from 8 +/- 3 to 1,340 +/- 327 microM/ml, we measured regional myocardial perfusion with radiolabeled microspheres. At baseline, regional myocardial perfusion to the collateral-dependent myocardium and to the normally perfused myocardium was simila...
Improvement in symptoms and exercise tolerance by metoprolol in patients with dilated cardiomyopathy: a double-blind, randomized, placebo-controlled trial.
Authors: R SEngelmeier, J BO'Connell, RWalsh, NRad, P JScanlon, R MGunnar
Journal: Circulation (1985)

It has been suspected that the increased sympathetic activity seen in patients with chronic congestive heart failure from dilated cardiomyopathy may be harmful. We therefore tested the long-term effect of metoprolol on eight patients in a double-blind, randomized protocol and 12 patients in an unblinded, crossover protocol who were treated for 12 months (range 10 to 24), and compared them with 16 similar subjects who were treated with placebo for 10 months (range 6 to 12) in a double-blind, randomized protocol. Patients were followed by serial clinical assessment, treadmill testing, radionuclide ventriculography, and echocardiography. Metoprolol-treated patients had an improvement in mean exercise capacity by 3 mets (p less than .0001) while experiencing a significant improvement in functional classification (p less than .001) during both the double-blind and open-label crossover studies and had an improved ejection fraction during the double-blind study (p less than .02). These improvements were not seen...