tbuckley/cabot-search huggingface dataset:
Determinants of drug response in severe chronic heart failure. 1. Activation of vasoconstrictor forces during vasodilator therapy.
Authors: MPacker, JMeller, NMedina, MYushak, RGorlin
Journal: Circulation (1981)

Vasodilator drugs activate neurohumoral forces that produce peripheral vasoconstriction and tachycardia and probably cause the rebound events observed upon abrupt withdrawal of therapy. To determine their role in limiting therapeutic vasodilator responses, these reactive forces were measured in 40 patients with severe chronic heart failure by quantifying the magnitude of rebound change (MRC) after nitroprusside withdrawal. Group 1 patients (n = 22), who had minimal reactive vasoconstriction (MRC less than or equal to 27%), showed marked hemodynamic effects with nitroprusside (4.5 microgram/kg/min) and isosorbide dinitrate (40 mg orally), associated with significant decreases in heart rate with both drugs (p less than 0.001). Despite administration of the same doses of both drugs, group 2 patients (n = 18), who had marked rebound changes (MRC greater than 27%), showed significantly smaller changes in cardiac index, systemic vascular resistance and mean arterial pressure (p less than 0.001), associated with...
The Underdeveloped “Gift”: Ethics in Implementing Precision Medicine Research
Authors: Amy A. Blumling, Kristin E. Childers-Buschle, John A. Lynch, Melanie F. Myers, Michelle L. McGowan
Journal: The American Journal of Bioethics (2021)

This article is referred to by:Response to Open Peer Commentaries: Distinguishing the "Gift" from "Donation" as a Path toward Reciprocity and Relational Ethics
Physiotherapy and Occupational Therapy and Mild to Moderate Parkinson Disease
Authors: Nienke M. de Vries, Ingrid H. Sturkenboom, Bastiaan R. Bloem
Journal: JAMA Neurology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
発作性心房細動の防止における右Atrial Pacing Preferenceの効果-Atrial Pacing Preference研究(APP研究)-
Authors: Ogawa Hideyuki, Ishikawa Toshiyuki, Matsushita Kouhei, Matsumoto Katsumi, Ishigami Tomoaki, Sugano Teruyasu, Uchino Kazuaki, Umemura Satoshi, Sumita Shinichi, Kimura Kazuo, Nakagawa Takeshi, Shimizu Makoto, Nishikawa Hideo, Kasai Atsunobu, Kioka Yukio
Journal: Circulation (2008)
Should women receive luteal support following natural cycle frozen embryo transfer? A systematic review and meta-analysis
Authors: Yossi Mizrachi, Eran Horowitz, Hadas Ganer Herman, Jacob Farhi, Arieh Raziel, Ariel Weissman
Journal: Human Reproduction Update (2021)

Abstract BACKGROUND Spontaneous ovulation during a natural menstrual cycle is frequently used for timing frozen embryo transfer (FET). Nevertheless, it remains unclear whether or not women should receive luteal phase support (LPS) following natural cycle frozen embryo transfer (NC-FET). OBJECTIVE AND RATIONALE The aim of this systematic review and meta-analysis was to study whether the administration of LPS improves the reproductive outcome following NC-FET. SEARCH METHODS We conducted a systematic search of the literature published in Medline/PubMed, Embase and the Cochrane Library, from January 2000 until December 2020. We included all original English, peer-reviewed articles, irrespective of the study design. The search strategy included keywords related to NC-FET and luteal phase support. Studies reporting the results of artificial or stimulated FET cycles were excluded. OUTCOMES Our systematic search generated 416 records. After screening, eight studies were included in the review and seven studies were included in the meta-analysis. Two studies (n = 858) used hCG and six studies (n = 1507) used progesterone for luteal support. Four studies were randomised controlled trials (RCTs), whereas the other four were historic cohort studies. In a meta-analysis using a random effects model, hCG administration for LPS did not increase the clinical pregnancy rate (CPR) (two studies, odds ratio (OR) 0.85, 95% CI 0.64–1.14). On the other hand, progesterone LPS was associated with a higher CPR (five studies, OR 1.48, 95% CI 1.14–1.94), and a higher live birth rate (LBR) (three studies, OR 1.67, 95% CI 1.19–2.36). The association between progesterone LPS and the LBR remained significant after excluding non-randomised studies. WIDER IMPLICATIONS The available evidence indicates that progesterone administration for LPS is beneficial following NC-FET. There is no evidence to support the administration of hCG for LPS in these cases. Additional large RCTs are necessary to improve the quality of evidence and validate our findings.
Drugs and breast-feeding.
Authors: B De Schuiteneer
Journal: BMJ (1979)

The administration of drugs is very often compatible with breastfeeding. It is now possible to determine the safety of prescribing a drug during lactation, provided that the following data are available: transfer of the drug into breast milk, pharmacokinetic parameters of the drug, recommended dosages for the neonate and the child. With these data, it is mostly possible to prescribe antibiotics, analgesics, antitussive agents, etc. during breastfeeding. However, it is of utmost importance to known the situations at risk for prescribing drugs during lactation, in order to avoid them. Finally, a short summary will give more information about the importance of some vitamins, especially vitamin K, during lactation.
Right ventricular ejection fraction in patients with acute anterior and inferior myocardial infarction assessed by radionuclide angiography.
Authors: ETobinick, H RSchelbert, HHenning, MLeWinter, ATaylor, W LAshburn, J SKarliner
Journal: Circulation (1978)

We measured right and left ventricular ejection fracttion (EF) from high frequency time-activity curves obtained during the initial passage of an intravenous bolus of 99mTc (Sn) pyrophosphate. In 22 normal controls right ventricular EF averaged 0.52 +/- 0.04 (SD). In 24 acute anterior or lateral infarction patients right ventricular EF was normal (0.56 +/- 0.10), while left ventricular EF was reduced (0.45 +/- 0.10, P less than 0.001 vs controls). In 19 acute inferior infarction patients left ventricular EF also was depressed (0.51 +/- 0.09, P less than 0.001 vs controls). Among 7 of 19 inferior infarction patients with right ventricular by scintigraphy, right ventricular EF was reduced (0.39 +/- 0.05; P less than 0.001 vs normals; P less than 0.01 vs inferior infarction patients without right ventricular involvement). In the latter group right ventricular EF averaged 0.51 +/- 0.10 (NS vs normals). We conclude 1) a single injection of 99mTc (Sn) pyrophosphate can identify right and left ventricular dysfun...
Cellular electrophysiological basis for oxygen radical-induced arrhythmias. A patch-clamp study in guinea pig ventricular myocytes.
Authors: ECerbai, GAmbrosio, FPorciatti, MChiariello, AGiotti, AMugelli
Journal: Circulation (1991)

BACKGROUNDOxygen radicals have been implicated in the pathogenesis of reperfusion arrhythmias. However, the basic electrophysiological alterations accompanying the effects of oxygen radicals on action potential (AP) are poorly understood.METHODS AND RESULTSWe investigated the effects of oxygen radicals generated by dihydroxyfumarate (DHF, 5 mM) on AP parameters and on ionic currents in patch-clamped guinea pig ventricular myocytes. DHF consistently caused a marked prolongation of AP duration, which was already significant after 60 seconds of exposure and continued to increase over time. Within 5 minutes, the majority of cells developed early afterdepolarizations (EADs) or became unexcitable. Both AP prolongation and occurrence of EADs were completely prevented in the presence of the oxygen radical scavengers superoxide dismutase (SOD) and catalase (CAT). Prolongation of AP duration was accompanied by a marked decreased in time-dependent potassium current (IK) and calcium current (ICa). The inward rectifie...
Role of endothelium-derived nitric oxide in the abnormal endothelium-dependent vascular relaxation of patients with essential hypertension.
Authors: J APanza, P RCasino, C MKilcoyne, A AQuyyumi
Journal: Circulation (1993)

BACKGROUNDPatients with essential hypertension have abnormal endothelium-dependent vasodilation. Because the endothelium exerts its action on the vascular smooth muscle through the release of several substances, it is important to identify which of these factors is involved in the abnormal response of hypertensive arteries.METHODS AND RESULTSTo investigate the role of endothelium-derived nitric oxide in this abnormality, we studied the vascular effect of the arginine analogue NG-monomethyl-L-arginine, an inhibitor of the endothelial synthesis of nitric oxide, under baseline conditions and during infusion of acetylcholine, an endothelium-dependent vasodilator, and sodium nitroprusside, a direct smooth muscle dilator. The study included 11 hypertensive patients (seven men; age, 46.5 +/- 9 years) and 10 normal control subjects (seven men; age, 45.7 +/- 7 years). Drugs were infused into the brachial artery, and the response of the forearm vasculature was measured by strain-gauge plethysmography. Basal blood f...
AuroraB kinase as a potential therapeutic target for biliary tract carcinoma
Authors: Chiun Hsu, Ling-Chun Yeh, Yu-Ting Chang, Ming-Chu Chang, Hui-Chen Hsu, Ann-Lii Cheng
Journal: Cancer Research (2007)

1819  Aurora kinases are over-expressed in a variety of cancers and strategies targeting aurora kinases are intensively studied as potential anti-cancer treatment. In this study we sought to explore the expression pattern of auroraB kinase in biliary tract carcinoma and the potential of using aurora kinase inhibition for the treatment of biliary tract carcinoma, which is resistant to most conventional cytotoxic agents. Archival tumor tissue was obtained from patients who underwent operation as an attempt of definitive treatment. Immunohistochemical staining with rabbit anti-auroraB kinase antibody (NB100-294, Novus) was used to evaluate the extent of nuclear staining. We tested the growth-inhibitory effect of VE-465, a small-molecule aurora kinase inhibitor provided by Merck, in a biliary tract carcinoma cell line HuCCT1. Cell viability was measured by trypan blue staining. Protein expression was evaluated by western blotting and immunocytochemistry. DNA content and apoptosis were measured by flow cytometry. A total of 162 patients with biliary tract carcinoma (74 intrahepatic cholangiocarcinoma, 49 extrahepatic bile duct carcinoma, and 39 gallbladder carcinoma) were evaluated. Nuclear expression of auroraB kinase, defined as moderate to strong nuclear staining in more than 10% of tumor cells, was found in 45 (27.8%) patients, including 19 of 64 stage I/II disease and 26 of 98 stage III/IV disease (p = 0.66). The median overall survival for patients with and without nuclear expression of auroraB kinase was 11.4 months and 17.7 months, respectively (p=0.03) Multi-variate analysis indicated that tumor stage and nuclear expression of auroraB kinase were significant prognostic factor (p
Letter by Nezami et al Regarding Article, “Platelet Reactivity and Cardiovascular Outcomes After Percutaneous Coronary Intervention: A Time-Dependent Analysis of the Gauging Responsiveness With a VerifyNow P2Y12 Assay: Impact on Thrombosis and Safety (GRAVITAS) Trial”
Authors: Nariman Nezami, Ourmaan Nezami Nargabad, Sona Ghorashi
Journal: Circulation (2012)

Price et al 1 have reported the results of the Gauging Responsiveness With a VerifyNow P2Y12 Assay: Impact on Thrombosis and Safety (GRAVITAS) trial in patients who had undergone percutaneous coronary intervention with Ն1 drug-eluting stents for the treatment of stable coronary artery disease or acute coronary syndrome at 83 sites in the United States and Canada.3] The authors have analyzed and compared the effect of statins as a covariant in the previously published articles. 2However, although the covariant effects of acute coronary syndrome presentation, diabetes mellitus, prior myocardial infarction, coronary artery bypass grafting, percutaneous coronary intervention, creatinine clearance, ␤-blocker at discharge, and total stent length were reported at 60 days and 6 months in the recent study, there is no result related to statin use and its covariant effect. 1 Statins show antiplatelet effects in patients with hypercholesterolemia and stable coronary artery disease.Ex vivo and in vivo evaluations showed lower platelet deposition, aggregate size, surface coverage, and collagen-induced platelet aggregation among statintreated patients.The authors of this article conclude that in acute myocardial infarction patients statins have an early antiplatelet effect in addition to that afforded by standard antiplatelet therapy. 4urthermore, clopidogrel (as a prodrug) requires hepatic cytochrome P450 metabolic activation to be converted to the active metabolite that is able to inhibit the platelet P2Y12 adenosinediphosphate receptor, decreasing platelet activation and aggregation processes.Statins, especially atorvastatin, have been identified that limit the ability of clopidogrel to inhibit platelet activation and aggregation processes in pharmacodynamic studies. 5ollectively, it would be helpful if, in their conclusion, the authors were to provide more information on the intake of statins, types of statins used, analysis of covariant effect, and the impact of statins on study outcomes.
Genome Analysis for Sequence Variants in SARS-CoV-2 Among Asymptomatic Individuals in a Long-term Care Facility
Authors: Baha Abdalhamid, Peter C. Iwen, Michael R. Wiley, Catherine B. Pratt, Steven H. Hinrichs
Journal: JAMA Network Open (2021)

Kevin A. Brown, PhD; Jonathan Gubbay, MBBS, MMedSc; Jessica Hopkins, MD, MHSc; Samir Patel, PhD; Sarah A. Buchan, PhD; Nick Daneman, MD, MSc; Lee William Goneau, PhD
Mechanisms of reoxygenation injury in cultured ventricular myocytes.
Authors: R AQuaife, OKohmoto, W HBarry
Journal: Circulation (1991)

To investigate factors contributing to reperfusion and reoxygenation myocardial injury, we exposed layers of cultured chick ventricular myocytes to severe hypoxia for up to 3 hours in the presence of 20 mM 2-deoxyglucose, zero glucose, and 5 mM pyruvate, and then exposed the myocytes to reoxygenation. Lactate dehydrogenase (LDH) release was moderately increased during 3 hours of hypoxia but was increased markedly during reoxygenation. Coincident changes in intracellular calcium concentration ([Ca2+]i) and cell motion were also measured during hypoxia and reoxygenation. During hypoxia, [Ca2+]i increased to more than 1 microM, and with reoxygenation, [Ca2+]i abruptly decreased slightly but remained elevated more than 1 microM. Cells developed a stable rigor after 30 minutes of hypoxia. Reoxygenation caused a marked hypercontracture within 5 minutes. Pretreatment of myocytes with either 2,3-butanedione monoxime, which inhibits Ca2(+)-dependent force development, or cyanide inhibited reoxygenation hypercontra...
Molecular biology of the natriuretic peptides and their receptors.
Authors: K JKoller, D VGoeddel
Journal: Circulation (1992)

After the description in the past 5 years of BNP and CNP, interest in the natriuretic peptide family has dramatically increased. Molecular characterization of the receptors for this hormone family has identified a heterogeneity in the receptor subtypes not previously alluded to by pharmacological or biochemical studies. Much has been published on the physiology of ANP, but the major roles for BNP and CNP remain to be elucidated. Some experiments indicate that ANP and BNP may act synergistically, especially during cardiac stress; however, the high level of structural diversity of BNP among species and the ability of porcine BNP, but not human BNP, to activate human NPR-B suggest that an as yet unidentified receptor may exist that specifically recognizes BNP. Localization studies have implied that CNP is the most prominent neuropeptide in the natriuretic peptide family, and the restriction of its receptor, NPR-B, to the nervous system suggests that CNP and NPR-B may act in the brain to coordinate the centra...
Enhanced atrioventricular nodal conduction in man: electrophysiologic effects of pharmacologic autonomic blockade.
Authors: D GBenditt, G JKlein, J MKriett, ADunnigan, D WBenson
Journal: Circulation (1984)

Enhanced atrioventricular nodal conduction (EAVC) comprises a portion of the spectrum of atrioventricular node electrophysiology in which physiologic slowing of atrioventricular conduction is diminished. To evaluate the basis of EAVC in humans, we compared the effect of pharmacologic autonomic blockade on electrophysiologic characteristics of atrioventricular nodal conduction and refractoriness in 10 patients with EAVC and 12 patients without EAVC (non-EAVC). The effects of autonomic blockade (0.2 mg/kg iv propranolol and 0.04 mg/kg iv atropine) on sinus cycle length and atrial refractory period were similar in both EAVC and non-EAVC patients. After autonomic blockade, minimum atrial paced cycle length with 1:1 atrioventricular conduction lengthened in EAVC patients (control, 268 +/- 25 msec; blockade, 307 +/- 34 msec; p less than .01), but remained unchanged in non-EAVC patients (control, 392 +/- 69 msec; blockade, 382 +/- 49 msec; p = NS). Similarly, atrioventricular nodal functional refractory periods ...
TCTAP C-100 Myocardial Infarction with Non-obstructive Coronary Arteries (MINOCA)
Authors: Vicknesan Kulasingham, Mahadevan Gurudevan, Heng Shee Kim, Kim Fong Ng, Hazrini Abdullah, Tee Choon Keong, Kumutha Gobal, Adelyn Nisha Henry
Journal: Journal of the American College of Cardiology (2021)
119P The role of circulating markers in predicting immune-related adverse events (irAEs) and their recurrence in advanced non-small cell lung cancer (aNSCLC) patients (pts)
Authors: A. Dal Maso, A. Pavan, A. Ferro, G. Pretelli, S. Frega, J. Menis, G. Pasello, V. Guarneri, P.F. Conte, L. Bonanno
Journal: Journal of Thoracic Oncology (2021)
Inexcitable right ventricle and bilateral bundle branch block in Uhl's disease.
Authors: SBharati, D ACiraulo, MBilitch, K MRosen, MLev
Journal: Circulation (1978)

A 29-year-old female with Uhl's anomaly developed complete atrioventricular (A-V) block. His bundle studies revealed block distal to the His bundle recording site with narrow QRS complexes. Right ventricular capture could not be obtained and despite successful left ventricular epicardial pacing, the patient died. Autopsy revealed absence of myocardium in most areas of the right ventricle and the right side of the ventricular septum with a normal tricuspid valve. Conduction system examination revelaed total destruction of both bundle branches. This is the first case where bilateral bundle branch block is shown to be present in Uhl's anomaly. Narrow QRS complexes probably reflected the absence of right ventricular forces.
Somatic Mutations in <i>UBA1</i> Define a Distinct Subset of Relapsing Polychondritis Patients With VEXAS
Authors: Marcela A. Ferrada, Keith A. Sikora, Yiming Luo, Kristina V. Wells, Bhavisha Patel, Emma M. Groarke, Daniela Ospina Cardona, Emily Rominger, Patrycja Hoffmann, Mimi T. Le, Zuoming Deng, Kaitlin A. Quinn, Emily Rose, Wanxia L. Tsai, Gustaf Wigerblad, Wendy Goodspeed, Anne Jones, Lorena Wilson, Oskar Schnappauf, Ryan S. Laird, Jeff Kim, Clint Allen, Arlene Sirajuddin, Marcus Chen, Massimo Gadina, Katherine R. Calvo, Mariana J. Kaplan, Robert A. Colbert, Ivona Aksentijevich, Neal S. Young, Sinisa Savic, Daniel L. Kastner, Amanda K. Ombrello, David B. Beck, Peter C. Grayson
Journal: Arthritis & Rheumatology (2021)

Objective Somatic mutations in UBA1 cause a newly defined syndrome known as VEXAS (vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic syndrome). More than 50% of patients currently identified as having VEXAS met diagnostic criteria for relapsing polychondritis (RP), but clinical features that characterize VEXAS within a cohort of patients with RP have not been defined. We undertook this study to define the prevalence of somatic mutations in UBA1 in patients with RP and to create an algorithm to identify patients with genetically confirmed VEXAS among those with RP. Methods Exome and targeted sequencing of UBA1 was performed in a prospective observational cohort of patients with RP. Clinical and immunologic characteristics of patients with RP were compared based on the presence or absence of UBA1 mutations. The random forest method was used to derive a clinical algorithm to identify patients with UBA1 mutations. Results Seven of 92 patients with RP (7.6%) had UBA1 mutations (referred to here as VEXAS‐RP). Patients with VEXAS‐RP were all male, were on average ≥45 years of age at disease onset, and commonly had fever, ear chondritis, skin involvement, deep vein thrombosis, and pulmonary infiltrates. No patient with VEXAS‐RP had chondritis of the airways or costochondritis. Mortality was greater in VEXAS‐RP than in RP (23% versus 4%; P = 0.029). Elevated acute‐phase reactants and hematologic abnormalities (e.g., macrocytic anemia, thrombocytopenia, lymphopenia, multiple myeloma, myelodysplastic syndrome) were prevalent in VEXAS‐RP. A decision tree algorithm based on male sex, a mean corpuscular volume &gt;100 fl, and a platelet count &lt;200 ×10 3 /μl differentiated VEXAS‐RP from RP with 100% sensitivity and 96% specificity. Conclusion Mutations in UBA1 were causal for disease in a subset of patients with RP. This subset of patients was defined by disease onset in the fifth decade of life or later, male sex, ear/nose chondritis, and hematologic abnormalities. Early identification is important in VEXAS given the associated high mortality rate.
Lung cancer: Current Status and Prospects for the Future
Journal: Thorax (1988)

This book contains 32 papers. Some of the titles are: Activation of cellular ras genes in human neoplasms; The valve of definitive radiation therapy of unresectable squamous cell carcinoma, large cell carcinoma, and adenocarcinoma of the lung; Current concepts of chemotherapy and radiotherapy for small cell lung cancer, and Current status of immunotherapy for lung cancer.
The Prevalence Of Histologically Coeliac Disease Compatible Cases With Normal Endoscopic Appearance In Previously Unsuspected Or With Mild Clinical Phenotype Patients
Authors: K Manukyan, A Khalatyan, S Khachatryan
Journal: Endoscopy (2021)

Aims There are many etiologic factors which may cause the coeliac type enteropathy (CTE)- NSAIDs, giardiasis, coeliac disease (CD), etc. The aim of this study to evaluate the histological findings received from duodenal biopsy and to investigate the prevalence of CD compatible cases with normal endoscopic appearance in previously unsuspected or with mild clinical phenotype patients.