tbuckley/cabot-search huggingface dataset:
Spinal (Subarachnoid) Block
Authors: Daniel C. Moore
Journal: JAMA (1966)

A computer study of 11,574 cases revealed spinal block to be a safe procedure provided (1) equipment is carefully cleaned, (2) both the equipment and drugs are heat sterilized together in a tray, and (3) the spinal block is administered with meticulous asepsis. In 8,852 patients, vasoconstrictor drugs were injected into the subarachnoid space along with the local anesthetic solution and they resulted in safe, consistent prolongation of anesthesia—epinephrine extended the duration by 50% and phenylephrine by 100%. Of the complications, hypotension was the most frequent. It occurred in 4,454 patients—1,225 prior to surgery and 3,229 during surgery. Headache resulted in 163 patients, backache in 48, postoperative vomiting in 233, peripheral nerve palsy in 17, but none were permanent. Prolonged spinal block occurred in two patients, and cardiac arrest occurred in four with three deaths. Since 1898 when August Bier produced spinal anesthesia by injecting cocaine into the subarachnoid space,
Just Words
Authors: Alexander Gode
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Association of Tranexamic Acid Administration With Mortality and Thromboembolic Events in Patients With Traumatic Injury
Authors: Vivien Karl, Sophie Thorn, Tim Mathes, Simone Hess, Marc Maegele
Journal: JAMA Network Open (2022)

<h3>Importance</h3> Tranexamic acid is widely available and used off-label in patients with bleeding traumatic injury, although the literature does not consistently agree on its efficacy and safety. <h3>Objective</h3> To examine the association of tranexamic acid administration with mortality and thromboembolic events compared with no treatment or with placebo in patients with traumatic injury in the literature. <h3>Data Sources</h3> On March 23, 2021, PubMed, Embase, and the Cochrane Library were searched for eligible studies published between 1986 and 2021. <h3>Study Selection</h3> Randomized clinical trials and observational studies investigating tranexamic acid administration compared with no treatment or placebo among patients with traumatic injury and traumatic brain injury who were 15 years or older were included. Included studies were published in English or German. The electronic search yielded 1546 records, of which 71 were considered for full-text screening. The selection process was performed independently by 2 reviewers. <h3>Data Extraction and Synthesis</h3> The study followed the Cochrane Handbook for Systematic Reviews of Interventions and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Data were extracted by 2 independent reviewers and pooled using the inverse-variance random-effects model. <h3>Main Outcomes and Measures</h3> Outcomes were formulated before data collection and included mortality at 24 hours and 28 and 30 days (1 month) as well as the incidence of thromboembolic events and the amount of blood products administered. Owing to missing data, overall mortality was added and the amount of blood products administered was discarded. <h3>Results</h3> Thirty-one studies with a total of 43 473 patients were included in the systematic review. The meta-analysis demonstrated that administration of tranexamic acid was associated with a significant decrease in 1-month mortality compared with the control cohort (risk ratio, 0.83 [95% CI, 0.71-0.97];<i>I</i><sup>2</sup> = 35%). The results of meta-analyses for 24-hour and overall mortality and thromboembolic events were heterogeneous and could not be pooled. Further investigations on clinical heterogeneity showed that populations with trauma and trial conditions differed markedly. <h3>Conclusions and Relevance</h3> These findings suggest that tranexamic acid may be beneficial in various patient populations with trauma. However, reasonable concerns about potential thromboembolic events with tranexamic acid remain.
Prevalence and Sources of Mistreatment Experienced by Internal Medicine Residents
Authors: Kathleen M. Finn, Alec B. O’Connor, Kelly McGarry, Linda Harris, Aimee Zaas
Journal: JAMA Internal Medicine (2022)

Prevalence and Sources of Mistreatment Experienced by Internal Medicine ResidentsMistreatment of trainees, defined as discrimination, harassment, or abuse in the workplace, is common 1-3 and associated with burnout, depression, and decreased self-confidence. 1 , 2 , 4 Recently, 2 national surveys of surgical residents provided details of mistreatment types and their sources. 1,4Less is known about internal medicine residents and how their experience with mistreatment compares with that of surgical residents.To our knowledge, no large national studies of internal medicine residents have been conducted, so we sought to assess the prevalence and sources of mistreatment with a national survey. 5,6 Methods | In August 2019, an anonymous 5-question optional survey was administered to internal medicine residents after they completed the American College of Physicians Internal Medicine In-Training Examination.We included the residents in US and Puerto Rico training programs.The Duke University School of Medicine institutional review board exempted the study from review.Residents were asked whether in their role as residents (ie, at any time during their residency) they had personally experienced or witnessed "inappropriate comments or actions [subsequently referred to as mistreatment] based on identity markers (eg, gender, race, ethnicity, sexual orientation, disabilities)," with response options for both comment and actions being "never," "infrequently," "sometimes," and "frequently."Residents were asked to identify the sources ("choose all that apply") from "patients," "patients' families," "nurses," "faculty," "residents," "allied health personnel," "other," and "not applicable."Residents were also asked if their program formally assessed residents regarding mistreatment.Because experiencing and witnessing mistreatment based on identity markers should ideally be an event that never occurs, we combined the responses of "infrequently," "sometimes," and "frequently" and compared these answers with the "never" responses.We used Pearson χ 2 test of independence to analyze whether experiencing or witnessing mistreatment significantly varied across gender or English as their primary language and to identify whether sources of mistreatment varied by the same factors.For all tests, we used an α of .05.Data analysis was conducted in Q Research Software (version 5.12.4.0).
Clinical Obstetrics.
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thomas Hodgkin's tomb in Jaffa
Authors: W. B. Bean
Journal: JAMA (1966)

<h3>To the Editor:—</h3> In the April issue of the<i>Archives of Internal Medicine</i>, I have published an account of a visit to Thomas Hodgkin's tomb at Jaffa in Israel. It seems appropriate on the 100th anniversary of his burial there to call this to the attention of others who might be interested. Your editor, knowing that I would be in Israel last summer, reminded me that Hodgkin was buried in Jaffa and told me that his efforts to visit the tomb were not successful because of conflicting plane schedules. Last summer, when I was in Israel, through the good offices of Dr. Joshua Leibowitz, professor of medical history at the Hebrew University, and through the courtesy of the university, which provided car, driver, and photographer, a small group of us did indeed make a pilgrimage to Hodgkin's tomb. Previously I had not been aware that he and Sir Moses Montefiore
BROWN-SEQUARD.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Biogun: A Novel Way of Eradicating Methicillin-Resistant <i>Staphylococcus Aureus</i> Colonization in Diabetic Foot Ulcers
Authors: Cuong Nguyen Dang, Ramzana Anwar, Gwen Thomas, Yemparala D.M. Prasad, Andrew J.M. Boulton, Rayaz A. Malik
Journal: Diabetes Care (2006)

garding age, BMI, and serum levels of TNF-RI and TNF-RII.The authors concluded that the HCV genotype must be included when evaluating insulin resistance in HCV-infected patients and suggest that other factors apart from TNF-␣ could be involved in the development of insulin resistance during HCV chronic infection.This letter deserves the following comments.First, we would like to specify that all the patients included in our study were genotype 1 (which is largely the most prevalent), and, therefore, a potential bias due to this issue can be absolutely ruled out.Second, and more importantly, it should be stressed that in our study, both groups of patients (anti-HCV negative and anti-HCV positive) were closely matched by the degree of liver fibrosis and several indexes of hepatic insulin extraction.In our view, this is a crucial point that should be considered when comparing patients with liver disease.The HOMA model is based on circulating insulin levels, and, therefore, the higher the degree of hepatic fibrosis the lower the rate of insulin extraction and, in consequence, the higher HOMA.Therefore, the measurement of hepatic insulin extraction should be provided before suggesting any influence of the HCV genotype in insulin resistance measured by HOMA.Finally, it should be noted that apart from TNF-␣ soluble receptors, we had also determined interleukin-6, and it was significantly higher in anti-HCV-positive than in anti-HCV-negative patients.Therefore, we agree with Petit et al. (1) that other factors apart from TNF-␣ could be implicated in the insulin resistance associated with HCV infection.In this regard, further studies to evaluate the contribution of other proinflammatory cytokines in the development of insulin resistance associated with HCV infection are warranted.
Frances and Anthony D'Anna International Memorial Symposium
Journal: JNCI Journal of the National Cancer Institute (1983)

Frances and Anthony D'Anna International Memorial Symposium Get access JNCI: Journal of the National Cancer Institute, Volume 70, Issue 2, February 1983, Page 387, https://doi.org/10.1093/jnci/70.2.387-c Published: 01 February 1983
Drug-induced deafness
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Coronary Angiography
Authors: Arnold Chait
Journal: JAMA (1974)

The increasing volume of coronary artery surgery being performed in institutions large and small has required that the skills of coronary angiography be more widely disseminated. This monograph addresses itself to that need. An attempt has been made to discuss all aspects of the subject including history, roentgenographic and catheterization equipment and techniques, normal and anomalous anatomy, diseases of the coronary arteries, and complications of angiography. The book is most successful in its discussion of the normal roentgenographic coronary artery anatomy. It is difficult to find the information concontained in this section between the covers of any other text. The long discussion of atheromatous disease and collateral pathways in obstructive disease is also to be highly recommended. The illustrations are of high quality and the many line drawings are superb. Less successful is the discussion of roentgenographic equipment and catheter technique. The authors err, I believe, in recommending specific products
Dual roles of B lymphocytes in mouse models of diet‐induced nonalcoholic fatty liver disease
Authors: Martin Karl, Solveig Hasselwander, Yawen Zhou, Gisela Reifenberg, Yong Ook Kim, Kyoung‐Sook Park, Dirk A. Ridder, Xiaoyu Wang, Eric Seidel, Nadine Hövelmeyer, Beate K. Straub, Huige Li, Detlef Schuppan, Ning Xia
Journal: Hepatology (2022)

Abstract Background and Aims Growing evidence suggests an important role of B cells in the development of NAFLD. However, a detailed functional analysis of B cell subsets in NAFLD pathogenesis is lacking. Approach and Results In wild‐type mice, 21 weeks of high fat diet (HFD) feeding resulted in NAFLD with massive macrovesicular steatosis, modest hepatic and adipose tissue inflammation, insulin resistance, and incipient fibrosis. Remarkably, B null ( JHT ) mice were partially protected whereas B cell harboring but antibody‐deficient IgMi mice were completely protected from the development of hepatic steatosis, inflammation, and fibrosis. The common feature of JHT and IgMi mice is that they do not secrete antibodies, whereas HFD feeding in wild‐type mice led to increased levels of serum IgG2c. Whereas JHT mice have no B cells at all, regulatory B cells were found in the liver of both wild‐type and IgMi mice. HFD reduced the number of regulatory B cells and IL‐10 production in the liver of wild‐type mice, whereas these increased in IgMi mice. Livers of patients with advanced liver fibrosis showed abundant deposition of IgG and stromal B cells and low numbers of IL‐10 expressing cells, compatible with our experimental data. Conclusions B lymphocytes have both detrimental and protective effects in HFD‐induced NAFLD. The lack of secreted pathogenic antibodies protects partially from NAFLD, whereas the presence of certain B cell subsets provides additional protection. IL‐10–producing regulatory B cells may represent such a protective B cell subset.
JAMA 75 YEARS AGO
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
JAMA Dermatology
Journal: JAMA Dermatology (2019)

Mission Statement JAMA Dermatology publishes information concerning the skin, its diseases, and their treatment.Its mission is to explicate the structure and function of the skin and its diseases and the art of using this information to deliver optimal medical and surgical care to the patient.We attempt to enhance the understanding of cutaneous pathophysiology and improve the clinician's ability to diagnose and treat skin disorders.This journal has a particular interest in publishing clinical and laboratory studies that reveal new information pertinent to the interests and needs of the medical dermatologist, dermatologic surgeon, and all those concerned with state-of-the-art care of cutaneous disease.We believe that knowledge derived from well-designed clinical trials and studies of cost-eff ectiveness are especially important for improving the practice of dermatology.Studies that increase the understanding of the outcome of treatment or the means by which the burden of dermatologic disease can be measured and reduced to promote the health of patients with skin disease will receive special priority.The journal regularly publishes reports on clinical investigations, editorials, and reviews.It also features reports and discussions on clinicopathologic correlations; clinical disorders of unique didactic value; pharmacologic, medical and surgical therapeutics; and ethical, moral, socioeconomic, and political issues.
Visual Field Studies.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of Thromboembolic Disease
Journal: New England Journal of Medicine (1966)

account for the findings of Coon et al. (1981) in using atropine following adrenaline for the treatment of pre-hospital cardiac arrests.There is thus good physiological support for the concept that consequent upon an episode of asystole there are times when a return to sinus rhythm is prevented by parasympathetic overactivity.It would seem logical, therefore, to administer atropine in these circumstances.
Director of Medical Education
Journal: New England Journal of Medicine (1955)

College of Forensic Psychiatry in Newport Beach, California.Keckich reporled a single case of violence, as a manifestation of akathisia, in which a man assaulted his dog with an intent to kill following treatment with low dose haloperidol in combination with impramine.1 Most clinicians have observed adverse CNS effects, of a mild to severe degree, to often occur in the first few days of treatment with high potency, low dose neuroleptic medications.Parkinsonian or extrapyramidal side effects, in patients under reELrlar treatment with currently popular neuroleptics, generally are found to be reduced and become less severe with reduction of dose or addition of antiparkinsonian aqents.Neuromuscular reactions such as motor restlessness, dystonia, akathisia, hyperreflexia, opisthotonos and oculogyric crists have been reported as occurring less frequently, but oftcn being very severe requiring discontinuation of the drug at times and, occasionally emergency room treatment.These agents (especially haloperidol) are increasinqly being used in emergency roonrs, hospital wards, and other settings for the raprd nnn*rnl ^{ ^^;+û (rrr L.,r (rr ..y,,..ted and violepl ncrrnlrntin a\/rnptoms and belravior.
Mindfulness-Oriented Recovery Enhancement vs Supportive Group Therapy for Co-occurring Opioid Misuse and Chronic Pain in Primary Care
Authors: Eric L. Garland, Adam W. Hanley, Yoshio Nakamura, John W. Barrett, Anne K. Baker, Sarah E. Reese, Michael R. Riquino, Brett Froeliger, Gary W. Donaldson
Journal: JAMA Internal Medicine (2022)

Successful treatment of opioid misuse among people with chronic pain has proven elusive. Guidelines recommend nonopioid therapies, but the efficacy of mindfulness-based interventions for opioid misuse is uncertain.