tbuckley/cabot-search huggingface dataset:
OUTCOMES OF CHOLANGIOSCOPY-GUIDED ELECTROHYDRAULIC LITHOTRIPSY FOR DIFFICULT BILE DUCT STONES: EXPERIENCE OF TWO HEPATOBILIARY UNITS IN GREECE
Authors: K. Paraskeva, V. Papastergiou, A. Giannakopoulos, A. Psistakis, M. Dinic, N. Pentilas, N. Androutsos, D. Makridaki, E. Themistocleous, E. Mastrokosta, V. Delatolas, S. Petraki, E. Vardas, G. Paspatis
Journal: Endoscopy (2022)

Aims Conventional endoscopic techniques for stone extraction fail in up to 10% of patients with common bile duct (CBD) stones. The Spyglass single-operator cholangioscopy (SOC) system provides the capability to fragment biliary stones under direct visualization using SOC-directed electrohydraulic lithotripsy (SOC-EHL). We evaluated the efficacy and safety of SOC-EHL in treating difficult CBS stones.
ROLE OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN DETERMINING THE MALIGNANT POTENTIAL OF PANCREATIC CYSTS
Authors: M. El-Nady, A. Altonbary, H. Hakim, A. Abou-Elmagd, W. Abbas, K. William
Journal: Endoscopy (2022)

Aims Pancreatic cysts are accidentally discovered in about 13% of cross-sectional imaging. Cysts with mucinous content have higher malignant potential. Therefore, differentiation between benign and malignant cysts is crucial. The aim of this study was to evaluate the possible roles of cystic fluid vascular endothelial growth factor A and R2 (VEGF-A and VEGF-R2) in differentiating between malignant and benign pancreatic cysts.
A QUALITATIVE QUESTIONNAIRE BASED STUDY TO INVESTIGATE PATIENT PREFERENCE AND BARRIERS FOR THE TIMING OF BOWEL PREPARATION PRIOR TO MORNING COLONOSCOPY
Authors: J. Dash, K. Siggens, M. Baker-Moffatt, L. Bombeo, H. Downe, P. Wilson, S.P. Aslam, H. Htet, M. Abdelrahim, P. Bhandari
Journal: Endoscopy (2022)

Aims In the UK split preparation isn’t routinely used for morning colonoscopies despite evidence showing split dose preparation results in better quality bowel cleansing. This study aims to identify patient preference for bowel preparation timing and explore barriers and solutions for introducing split dosing for morning colonoscopy.
RISK FACTORS FOR UNDERESTIMATION OF PATIENT PAIN IN OUTPATIENT COLONOSCOPY
Authors: J. Ryhlander, G. Ringström, B. Lindkvist, P. Hedenström
Journal: Endoscopy (2022)

Aims Adequate management of patient pain and discomfort during colonoscopy is crucial to obtain a high-quality examination. We aimed to investigate the ability of endoscopists and endoscopy assistants in accurately assessing patient pain in colonoscopy.
CAUSTIC INGESTION:ENDOSCOPIC FINDINGS AND COMPLICATIONS
Authors: Z. Tammouch, O. El mqaddem, K. Rais, F. Amri, O. ElEulj, M. Oustani, M. Nasiri, A. Zazour, W. Khannoussi, G. Kharrasse, Z. Ismaili
Journal: Endoscopy (2022)

Aims The aim of this study is to determine clinical ,endoscopic aspects of caustic digestive lesions and complications in relation to the type of caustic substance.
THE TIMING OF POSTOPERATIVE ILEOCOLOSCOPY AND THE SEVERITY OF THE RUTGEERTS SCORE: WHAT IS THE LINK?
Authors: A. Hassine, A. Hammami, W. Dahmeni, W. Ben Ameur, A. Ben Slama, N. Elleuch, A. Braham, M. Ksiaa, H. Jaziri, A. Jmaa
Journal: Endoscopy (2022)

Aims Currently, we recommend performing an ileocolonoscopy between 6 and 12 months to assess endoscopic recurrence in Crohn's disease (CD) patients after bowel resection using the Rutgeerts score (RS).The aim of our study was to determine the correlation between a first postoperative ileocoloscopy performed after one year and the severity of the endoscopic recurrence.
Deciphering radiological stable disease to immune checkpoint inhibitors
Authors: J. Luo, S. Wu, H. Rizvi, Q. Zhang, J.V. Egger, J.C. Osorio, A.J. Schoenfeld, A.J. Plodkowski, M.S. Ginsberg, M.K. Callahan, C. Maher, A.N. Shoushtari, M.A. Postow, M.H. Voss, R.R. Kotecha, A. Gupta, R. Raja, M.G. Kris, M.D. Hellmann
Journal: Annals of Oncology (2022)
EUS-GUIDED CHOLEDOCHODUODENOSTOMY TO TREAT BILIARY OBSTRUCTION IN A PATIENT WITH LOCALLY ADVANCED PANCREATIC CANCER
Authors: M. Lajin
Journal: Endoscopy (2022)

A 73-year-old male presented with jaundice. CT showed a dilated CBD and PD. EUS revealed a 3 cm mass invading the portal vein, FNB revealed adenocarcinoma.
Induction of functional neutrophils from mouse fibroblasts by thymidine through enhancement of Tet3 activity
Authors: Buqing Ye, Liuliu Yang, Benyu Liu, Nian Liu, Dongdong Fan, Huimu Li, Lei Sun, Ying Du, Shuo Wang, Yong Tian, Zusen Fan
Journal: Cellular and Molecular Immunology (2022)
Oxidative stress-amplified nanomedicine for intensified ferroptosis-apoptosis combined tumor therapy
Authors: Mian Yu, Jiayin Yu, Yunfei Yi, Ting Chen, Liu Yu, Weiwei Zeng, Xiao-kun Ouyang, Chenyi Huang, Shengjie Sun, Yang Wang, Yuanqi Liu, Chuchu Lin, Meiying Wu, Lin Mei
Journal: Journal of Controlled Release (2022)
Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus
Authors: Miho Shinzawa, E. Ashley Moseman, Selamawit Gossa, Yasuko Mano, Abhisek Bhattacharya, Terry Guinter, Amala Alag, Xiongfong Chen, Maggie Cam, Dorian B. McGavern, Batu Erman, Alfred Singer
Journal: Nature Immunology (2022)

Abstract T cell specificity and function are linked during development, as MHC-II-specific TCR signals generate CD4 helper T cells and MHC-I-specific TCR signals generate CD8 cytotoxic T cells, but the basis remains uncertain. We now report that switching coreceptor proteins encoded by Cd4 and Cd8 gene loci functionally reverses the T cell immune system, generating CD4 cytotoxic and CD8 helper T cells. Such functional reversal reveals that coreceptor proteins promote the helper-lineage fate when encoded by Cd4 , but promote the cytotoxic-lineage fate when encoded in Cd8 —regardless of the coreceptor proteins each locus encodes. Thus, T cell lineage fate is determined by cis -regulatory elements in coreceptor gene loci and is not determined by the coreceptor proteins they encode, invalidating coreceptor signal strength as the basis of lineage fate determination. Moreover, we consider that evolution selected the particular coreceptor proteins that Cd4 and Cd8 gene loci encode to avoid generating functionally reversed T cells because they fail to promote protective immunity against environmental pathogens.
DETECTION RATE OF SESSILE SERRATED LESIONS AND ACCURACY OF OPTICAL BIOPSY AS QUALITY INDICATORS
Authors: A. Gubbiotti, M. Spadaccini, R. Maselli, A. Anderloni, S. Carrara, A. Galtieri, E.C. Ferrara, G. Pellegatta, A. Fugazza, L. Alfarone, L. Da Rio, G. Migliorisi, B. Masoni, L. Brandaleone, P. Bertoli, V. Poletti, S. Ferretti, D. Polverini, G. Marcozzi, M. Terrin, E. Mastrorocco, G. Franchellucci, C. Hassan, A. Repici
Journal: Endoscopy (2022)

Aims Serrated pathway is thought to account for up to one-third of overall colorectal cancers(CRC),and a plausible cause of interval CRC.There is discordance in detection outcomes both from endoscopist and pathologist perspectives.Our study aims to report the SL detection performances in a large cohort of patients and investigate factors affecting endoscopist performances.
TOGETHER WE STAND FOR TOUGH LOCALIZATION; ENDOSCOPIC SUBMUCOSAL DISSECTION TREATMENT OF EARLY STAGE ESOPHAGEAL CARCINOMA
Authors: F. Aslan, O. Gokler, A.B. Ak, O.C. Taskin, K. Gokce, M. Manici
Journal: Endoscopy (2022)

A 40-year-old female patient evaluated with endoscopy for reflux symptoms that are refractory to PPI treatment.On endoscopy there was a 5cm in diameter flat undyed area at upper-esophagus starting from hypopharynx and involving bilateral pyriform-sinuses.On CT and endoscopic-ultrasonography, there was no pathological lymph node and invasion the muscularis propria observed.Patient was treated with ESD on a joint operation with head-neck-surgeon.During procedure, the submucosal tunnels was made starting from both pyriform-sinuses and the rest of the submucosal dissection was completed with traction provided with laryngoscope.The lesion was externalized upon en-bloc removal. The lesion was reported as intramucosal carcinoma with clear all-margins.
Correction: The long and short non-coding RNAs modulating EZH2 signaling in cancer
Authors: Sepideh Mirzaei, Mohammad Hossein Gholami, Kiavash Hushmandi, Farid Hashemi, Amirhossein Zabolian, Israel Canadas, Ali Zarrabi, Noushin Nabavi, Amir Reza Aref, Francesco Crea, Yuzhuo Wang, Milad Ashrafizadeh, Alan Prem Kumar
Journal: Journal of Hematology & Oncology (2022)
MINIMAL RESIDUAL INTRAHEPATIC LITHIASIS TREATED WITH INTRADUCTAL LITHOTRIPSY
Authors: M. Sacco, M. Gesualdo, S. Caronna, W. Debernardi Venon, C.G. De Angelis
Journal: Endoscopy (2022)

This video present a case of combined extra- and intrahepatic lithiasis; patient underwent a first ERCP with mechanic lithotripsy and removal of stones from common bile duct (CBD). Since patient was still mild symptomatic and blood test did not normalize, a new cholangio-MRI was performed, showing residual intrahepatic lithiasis.
ENDOSCOPIC ULTRASOUND-GUIDED THROUGH-THE-NEEDLE MICROFORCEP BIOPSY IMPROVES THE CATEGORIZATION OF THE TYPE OF PANCREATIC CYSTIC LESIONS
Authors: S.H. Cho, T.J. Song, D.-W. Seo, D. Oh, D.H. Park, S.S. Lee, S.K. Lee, M.-H. Kim
Journal: Endoscopy (2022)

Aims Endoscopic ultrasound-guided through-the-needle biopsy (EUS-TTNB) was introduced and has been performed for the diagnosis of pancreatic cystic lesions (PCLs). However, there is limited data regarding its efficacy and safety. We aimed to evaluate the feasibility, efficacy, and safety of EUS-TTNB in categorizing the types of PCLs, and to analyze factors associated with diagnostic failure.
Redefining the epidemiology of cardiac amyloidosis. A systematic review and meta‐analysis of screening studies
Authors: Alberto Aimo, Marco Merlo, Aldostefano Porcari, Georgios Georgiopoulos, Linda Pagura, Giuseppe Vergaro, Gianfranco Sinagra, Michele Emdin, Claudio Rapezzi
Journal: European Journal of Heart Failure (2022)

An algorithm for non-invasive diagnosis of amyloid transthyretin cardiac amyloidosis (ATTR-CA) and novel disease-modifying therapies have prompted an active search for CA. We examined the prevalence of CA in different settings based on literature data.We performed a systematic search for screening studies on CA, focusing on the prevalence, sex and age distribution in different clinical settings. The prevalence of CA in different settings was as follows: bone scintigraphy for non-cardiac reasons (n = 5 studies), 1% (95% confidence interval [CI] 0%-1%); heart failure with preserved ejection fraction (n = 6), 12% (95% CI 6%-20%); heart failure with reduced or mildly reduced ejection fraction (n = 2), 10% (95% CI 6%-15%); conduction disorders warranting pacemaker implantation (n = 1), 2% (95% CI 0%-4%); surgery for carpal tunnel syndrome (n = 3), 7% (95% CI 5%-10%); hypertrophic cardiomyopathy phenotype (n = 2), 7% (95% CI 5%-9%); severe aortic stenosis (n = 7), 8% (95% CI 5%-13%); autopsy series of 'unselected' elderly individuals (n = 4), 21% (95% CI 7%-39%). The average age of CA patients in the different settings ranged from 74 to 90 years, and the percentage of men from 50% to 100%. Many patients had ATTR-CA, but the average percentage of patients with amyloid light-chain (AL) CA was up to 18%.Searching for CA in specific settings allows to identify a relatively high number of cases who may be eligible for treatment if the diagnosis is unequivocal. ATTR-CA accounts for many cases of CA across the different settings, but AL-CA is not infrequent. Median age at diagnosis falls in the eighth or ninth decades, and many patients diagnosed with CA are women.
TRANSORAL INCISIONLESS FUNDOPLICATION WITH ESOPHYX-Z 2.0 FOR THE TREATMENT OF GASTROESOPHAGEAL REFLUX AFTER LAPAROSCOPIC HERNIA REPAIR (CTIF). FIRST PROCEDURE IN EUROPE
Authors: R. Temiño López-Jurado, R. Turró Arau, J. Osorio Aguilar, M. Martí Ragué, M. Rosinach Ribera, B. González Suárez, M. Ble Caso, A. Ortega Sabater, J.C Espinós Pérez
Journal: Endoscopy (2022)

A laparoscopic repair of diaphragmatic crura is done under general anesthesia. Inmediatly after the hernia repair is completed the EsophyX-Z is introduced through the mouth and advanced into the stomach under direct visualization with the scope inside the device. Then in a retroflexed position an helical retractor is directed towards the Z line, where the tissue is nailed and pulled into the mold, while the device is rotated. Each shot releases two fasteners, which produces the apposition of esophageal and fundic tissue. This process is repeated to create a partial fundoplication of 270 degrees (20 fasteners).
BALLOON DILATOR MANAGEMENT OF BURIED BUMPER SYNDROME
Authors: M.D. Ramis Estelrich, J. Fernández García, B. Bartrolí Alabau, S. Khorrami Minaei, I.M. García Amengual, C. Garrido Duran
Journal: Endoscopy (2022)

Aims Buried bumper syndrome is a rare complication of percutaneous endoscopic gastrostomy (PEG). The internal bumper migrates through the stomach wall, which hampers the tube function and blocks its removal.
ENDOSCOPIC ELECTROINCISION OF DIFFICULT ANASTOMOTIC BILIARY STRICTURE AFTER LIVER TRANSPLATATION
Authors: A. Tringali, S.M. Milluzzo, V. Perri, G. Costamagna
Journal: Endoscopy (2022)

Benign biliary stenosis (BBS) can be caused by a variety of etiologies, including post-operative injuries (i.e., post-cholecystectomy, liver transplantation), chronic pancreatitis, chronic cholangiopathies and traumas.
Covid-19: True global death toll from pandemic is almost 15 million, says WHO
Authors: Luke Taylor
Journal: BMJ (2022)

Covid-19: True global death toll from pandemic is almost 15 million, says WHO Luke TaylorThe global number of deaths caused by covid-19 has been severely under-reported, the World Health Organization has said.It estimates that 14.9 million direct and indirect deaths occurred from SARS-CoV-2 in 2020 and 2021-almost three times the 5.4 million reported by governments around the world.
ENDOSCOPIC ULTRASOUND-GUIDED RADIOFREQUENCY ABLATION (EUS-RFA) OF GASTROINTESTINAL TUMORS: ANALYSIS OF INDICATIONS AND LONG-TERM RESULTS
Authors: A.Y. Carbajo, C. De la Serna Higuera, E. Fuentes Valenzuela, B. Madrigal, R. Sanchez-Ocaña, C. Maroto, L. Sanchez, M. De Benito, M. Dura, M. Perez-Miranda
Journal: Endoscopy (2022)

Aims Surgery is the mainstay therapy for some types of pancreatic tumors. In recent years, EUS-RFA has been described as an effective therapeutic option in poor surgical candidates. There is scant evidence in other types of digestive neoplasms. Aims: to assess efficacy and safe of EUS-RFA in the treatment of gastrointestinal tumors.
AN AUTOMATIC DIAGNOSIS SYSTEM FOR CHRONIC ATROPHIC GASTRITIS UNDER WHITE LIGHT ENDOSCOPY BASED ON DEEP LEARNING
Authors: T. Xiao, S. Renduo, W. Lianlian, Y. Honggang
Journal: Endoscopy (2022)

Aims Regular endoscopic monitoring is generally recommended for patients with atrophic gastritis(AG) because of their increased risk of gastric cancer. However, the diagnostic accuracy of AG under white light endoscopy often varies with the experience of endoscopists. We aim to develop a model based on deep learning DL that can automatically diagnose atrophic gastritis in different anatomical sites of the stomach.
ANTIBIOTIC PROPHYLAXIS FOR ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY (ERCP): A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: M.F. Shinin Merchan, C. Flaksbaum Moll, J.M. Vera Intriago, E. Silvino Do Monte Junior, I. Mendonça Proença, D.T.H. De Moura, W. Marques Bernardo, E. Guimaraes Hourneaux De Moura
Journal: Endoscopy (2022)

Aims The prophylactic use of antibiotics in endoscopic retrograde cholangiopancreatography is still controversial. The literature is yet conflicting about indications. The iam of this meta-analysis is to assess antibiotic prophylaxis to reduce the incidence of septicemia and cholangitis in patients undergoing elective ERCP.
CAPSULE ENDOSCOPY IN PATIENTS WITH MECKEL`S DIVERTICULUM- CLINICAL FEATURES AND DIAGNOSTIC FINDINGS – A EUROPEAN MULTICENTRE STUDY
Authors: P. Baltes, X. Dray, M.E. Riccioni, E. Pérez-Cuadrado-Robles, E. Fedorov, F. Wiedbrauck, S. Chetcuti Zammit, S. Cadoni, M. Bruno, E. Rondonotti, G. Wurm Johansson, A. Mussetto, H. Beaumont, G. Perrod, D. McNamara, J. Plevris, C. Spada, R. Pinho, B. Rosa, N. Hervás, C. Carretero, G.E. Tontini, M. Keuchel
Journal: Endoscopy (2022)

Aims Evaluation of indicative capsule endoscopy (CE) findings in patients with diagnosis of Meckel`s diverticulum (MD) in context of clinical presentation.
EFFICACY OF DYE-BASED CHROMOENDOSCOPY FOR COLORECTAL NEOPLASIA DETECTION: A SYSTEMATIC REVIEW AND METANALYSIS
Authors: G. Antonelli, L. Correale, M. Spadaccini, R. Maselli, F. Cereatti, S. Pecere, G. Bevivino, F. Iacopini, A. Repici, C. Hassan
Journal: Endoscopy (2022)

Aims Dye-Based chromoendoscopy (DBC) has shown to be effective in increasing adenoma detection rate (ADR), but the technique is time-consuming and its uptake is limited. The burden of dye spraying the colon has recently been cut down by the possibility to orally administer the dye during bowel preparation. We aimed to assess the effect of DBC in increasing ADR including only randomized controlled trials (RCTs).
UPPER ENDOSCOPY FINDINGS IN PATIENTS WITH FAMILIAL ADENOMATOUS POLYPOSIS
Authors: K. Jankovic, I. Jovanovic
Journal: Endoscopy (2022)

Aims It is know that patients with familial adenomatous polyposis (FAP) are at risk for other cancer mainly arising from other parts of the gastrointestinal (GI) tract. Therefore, this study was aimed to assess the upper endoscopy findings observed in our cohort.
T1 COLORECTAL CANCERS TREATED BY ENDOSCOPIC RESECTION: TUMOR SIZE AS A NEW PROGNOSTIC FACTOR?
Authors: F. Corre, M. Barret, T. Lambin, J.-P. Ratone, V. Lepilliez, E. Coron, J. Albouys, G. Rahmi, D. Karsenti, J.-M. Canard, E. Chabrun, M. Camus, T. Wallenhorst, M. François, R. Gerard, A. Rouquette, B. Terris, R. Coriat, M. Pioche, J. Jacques, S. Chaussade
Journal: Endoscopy (2022)

Aims Tumor size seems to be an important prognostic factor in colorectal cancers, especially in T1. The objective of this study was to compare the rate of lymph node involvment between small≤20mm T1 colorectal tumors and those of larger size>20mm.
90TiP Adjuvant study of amcenestrant (SAR439859) versus tamoxifen for patients with hormone receptor-positive (HR+) early breast cancer (EBC), who have discontinued adjuvant aromatase inhibitor therapy due to treatment-related toxicity (AMEERA-6)
Authors: G. Rossi, E. Brain, A. Dueck, H. De Swert, S.I. Marreaud, A. Partridge, C. Herold, H. Vachon, T. Spanic, A. Arahmani, T. Verbiest, L. Wang, T. Goulioti, B. Malanda, L.A. Carey, S. Anneheim, G. Paux, C. Poncet, O. Metzger, D. Cameron
Journal: Annals of Oncology (2022)
181P Efficacy of eribulin mesylate in HER2-low metastatic breast cancer (MBC): Results from a pooled analysis of two phase III studies
Authors: C.J. Twelves, J. Cortés, P.A. Kaufman, A.H. Awada, S-A. Im, W. Hauck, I. Greenfield, R. Xie, L.T. Vahdat
Journal: Annals of Oncology (2022)
PANCREATIC CYST FLUID INTERLEUKIN-1 BETA (IL-1Β) LEVEL IN PREDICTING THE RISK OF MALIGNANCY IN PANCREATIC CYSTS.
Authors: T. Abdallah, S. Shalaby, A. Salem, T. Yousef, S. Saleh, H. Okasha, M. Zaghloul, M. El-Nady
Journal: Endoscopy (2022)

Pancreatic cystic lesions (PCLs) may be accidentally discovered in up to 13.5% of cases. These PCLs are of multiple types, including mucinous cysts (intra-ductal papillary mucinous neoplasms [IPMN] and mucinous cystic neoplasms [MCN]) that have a risk of malignant transformation. The difficulty in differentiation between the various PCLs and their unpredictable risk of malignant transformation makes their management difficult. The new diagnostic tools of PCLs often include endoscopic ultrasound guided fine needle aspiration (EUS-FNA) for pancreatic cyst fluid analysis. This study aimed to determine if cystic fluid IL-1β can predict the risk of malignancy and the degrees of dysplasia of pancreatic cysts. The study included 50 PCL patients. They were subjected to radiological, biochemical, serological, and histopathological examinations. Pancreatic cyst fluid IL-1β was analyzed using an ELISA. Our data indicated that cyst fluid IL-1 β can differentiate between benign and malignant cysts at cut-off value >150 pg/ml; with sensitivity and specificity of 84.00% and 56.00% respectively. Also, cyst fluid IL-1 β can differentiate between mucinous and non- mucinous pancreatic cysts at cut-off value >150 pg/ml; with a sensitivity and specificity of 83.33% and 53.78%, respectively. However, cyst fluid IL-1 β cannot differentiate between degrees of dysplasia of IPMN. In conclusion, our study suggested that pancreatic cyst fluid IL-1β can differentiate between.
TECHNICAL ASPECTS, INDICATIONS AND OUTCOMES OF COLONOSCOPY IN THE ELDERLY. A LARGE COMPARATIVE COHORT STUDY
Authors: F. Abu Baker, M. Suki, A. Beshara, B. Ovadia, O. Gal, Y. Kopelman
Journal: Endoscopy (2022)

Aims We aimed to investigate various aspects pertaining to colonoscopy performance in elderly patients and to provide indication-based assessment of colonoscopies' yield and outcome.
Blockade of mIL‐6R alleviated lipopolysaccharide‐induced systemic inflammatory response syndrome by suppressing NF‐κB‐mediated Ccl2 expression and inflammasome activation
Authors: Ji‐Min Dai, Xue‐Qin Zhang, Jia‐Jia Zhang, Wei‐Jie Yang, Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen
Journal: MedComm (2022)

Systemic inflammatory response syndrome (SIRS) is characterized by dysregulated cytokine release, immune responses and is associated with organ dysfunction. IL-6R blockade indicates promising therapeutic effects in cytokine release storm but still remains unknown in SIRS. To address the issue, we generated the human il-6r knock-in mice and a defined epitope murine anti-human membrane-bound IL-6R (mIL-6R) mAb named h-mIL-6R mAb. We found that the h-mIL-6R and the commercial IL-6R mAb Tocilizumab significantly improved the survival rate, reduced the levels of TNF-α, IL-6, IL-1β, IFN-γ, transaminases and blood urea nitrogen of LPS-induced SIRS mice. Besides, the h-mIL-6R mAb could also dramatically reduce the levels of inflammatory cytokines in LPS-treated THP-1 cells in vitro. RNA-seq analysis indicated that the h-mIL-6R mAb could regulate LPS-induced activation of NF-κB/Ccl2 and NOD-like receptor signaling pathways. Furthermore, we found that the h-mIL-6R mAb could forwardly inhibit Ccl2 expression and NLRP3-mediated pyroptosis by suppressing NF-κB in combination with the NF-κB inhibitor. Collectively, mIL-6R mAbs suppressed NF-κB/Ccl2 signaling and inflammasome activation. IL-6R mAbs are potential alternative therapeutics for suppressing excessive cytokine release, over-activated inflammatory responses and alleviating organ injuries in SIRS.
PREDICTION OF LARGE ESOPHAGEAL VARICES IN PATIENTS WITH COMPENSATED CIRRHOSIS USING IMAGING PARAMETERS
Authors: A. Hassine, S. Mrabet, R. Tababi, R. Harbi, I. Akkari, A. Hassine, E. Ben Jazia
Journal: Endoscopy (2022)

Aims Upper gastrointestinal endoscopy (UGE) remains the gold standard for Portal-hypertension screening. However, this method is invasive and expansive. Noninvasive methods are needed to identify clinically significant portal hypertension and esophageal varices (EV) in patients with compensated cirrhosis. This study aims to establish the role of spleen size and portal vein diameter by ultrasonography in predicting large EV.
FOOD RESIDUE LIMITING VIEWS AT GASTROSCOPY: A REVIEW OF PATIENT CHARACTERISTICS AND MANAGEMENT STRATEGIES
Authors: M. McNally, K. Malik, M. Shah, M. Thoufeeq
Journal: Endoscopy (2022)

Aims The aim of this study was to review the frequency of food residue limiting views at gastroscopy, assess associated patient characteristics, and identify management strategies to reduce food stasis in high-risk patients.