tbuckley/cabot-search huggingface dataset:
Abstract P074: Heterogeneity In Proportional Mortality Due To Atherosclerosis By Age Amongst Asian Americans
Authors: Abhyuday Chauhan, Deepak R Nair, Dhananjay Vaidya
Journal: Circulation (2021)

Background: Asian American subgroups (AAS) differ amongst one another in terms of proportion of mortality (PM) due to atherosclerosis disease (ASD). However, differences in PM based on early onset (35-64 years) and older age (≥65 years) ASD deaths within each subgroup have not been well studied. Methods: US resident death records were examined from 2017 mortality data (National Center for Health Statistics). Race/ethnicity and underlying ASD cause (ICD-10 code of ischemic heart disease I20-I25, ischemic stroke I69, atherosclerosis I70, respectively) were tabulated for Asian-American subgroups and major US race/ethnicities (listed in Table). Age and sex standardized PM percentage was calculated overall for each ethnicity and separately for early and older age deaths within each ethnic group. The age by ethnicity interaction was tested using general linear models. Results: Over all ages, Filipinos and Asian Indians had the highest ASD PM while Vietnamese and Japanese had the lowest ASD PM, with other groups being intermediate. Compared with NHW, ASD PM was high in both age groups for Asian Indians and Filipino, while age difference PM in these ethnic groups was no different when compared to NHW – suggesting early and persistently high ASD. In contrast, Amerindians, Hispanics, Koreans and Chinese when compared to NHW had a low early age ASD PM, increasing significantly at older ages, suggesting the mortality burden is mostly at older ages. Conclusion: AAS are heterogeneous in terms of the overall burden of percent ASD mortality and the age at which it predominates. Asian Indians and Filipinos had the highest PM burden due to ASD over all ages, premature and older. On the other hand, premature ASD mortality burden was lowest in Koreans and Chinese amongst the AAS with a disproportionate increase in death in the elderly population. AAS subgroups need different strategies for prevention, with Asian Indians and Filipinos being targeted earlier in their life course.
Abstract P192: Depression And Anxiety Are Associated With Cardiovascular Health In Young Adults
Authors: Sierra L Patterson, Michele Marcus, Margarethe Goetz, Holly C Gooding
Journal: Circulation (2021)

Introduction: Cardiovascular health (CVH) declines substantially in young adulthood, and mood disorders commonly emerge during this life stage. This study aimed to examine the association between CVH metrics and 1) depression and 2) anxiety among young adults ages 18-34 years. Hypothesis: We hypothesized that young adults with depression or anxiety will have less optimal CVH. Methods: We used data from the Emory Healthy Aging Study (EHAS), a prospective cohort study of US adults that aims to understand factors associated with aging. We conducted a cross-sectional analysis among participants ages 18-34 years who completed the EHAS Health History Questionnaire (n=882). We classified participants as having poor, intermediate, or ideal levels of the seven CVH metrics using definitions set forth by the AHA, with slight modifications as needed based on questionnaire items, and calculated total CVH scores (range 0-14). We defined depression and anxiety as absent, mild, or moderate-to-severe using standard cutoffs for Patient Health Questionnaire (PHQ-8) and General Anxiety Disorder (GAD) scales. We used multivariable regression to examine the association between CVH, depression, and anxiety, controlling for gender, race, age group, income, and education. Results: A total of 134 (15.2%) participants had moderate-to-severe anxiety, and 132 (15.0%) participants had moderate-to-severe depression. The mean total CVH score among participants was 10.4. Compared to those without anxiety, participants with moderate-to-severe anxiety were less likely to meet ideal levels of physical activity (PR: 0.63, 95% CI: 0.44-0.90), smoking (PR: 0.89, 95% CI: 0.81-0.98), and body mass index (PR: 0.78, 95% CI: 0.65-0.94). Participants with moderate-to-severe depression were less likely to meet ideal levels of cholesterol (PR: 0.93, 95% CI: 0.86-1.00), physical activity (PR: 0.45, 95% CI: 0.30-0.69), smoking (PR: 0.89, 95% CI: 0.79-0.99), blood pressure (PR: 0.91, 95% CI: 0.84-0.98), and body mass index (PR: 0.81, 95% CI: 0.71-0.93). Stratified analysis showed that these associations appeared stronger in older young adults (26-34 years). Relative to those without anxiety, participants with moderate-to-severe anxiety had a CVH score that was 0.91 points lower (standard error: 0.18, p-value&lt;0.01). Relative to those without depression, participants with moderate-to-severe depression had a CVH score that was 1.19 points lower (standard error: 0.18, p-value&lt;0.01). Conclusion: Anxiety and depression are associated with CVH in young adults. Interventions to address mood disorders in this age group should consider targeting CVH behaviors such as physical activity and weight management to improve both mood and CVH.
Abstract 13558: Caregiver Anxiety Reduced From Baseline to 12 Months After Surgery: Findings From the Sustaining Quality of Life of the Aged: Heart Transplant or Mechanical Circulatory Support ( <i>Sustain-it</i> ) Study
Authors: Michael Petty, Adin-Cristian Andrei, Christian Elenbaas, Anna Warzecha, Clyde Yancy, Duc Pham, Andrew Kao, John Spertus, Eileen M Hsich, Mary Amanda Dew, Christopher Sciortino, Justin HARTUPEE, William Cotts, Salpy Pamboukian, Francis D Pagani, Brent Lampert, Maryl R Johnson, Margaret A Murray, Koji Takeda, Melana Yusefpolskaya, Scott Silvestry, James Kirklin, Craig Collum, Kathleen L Grady
Journal: Circulation (2020)

Introduction: Caregivers (CGs) of heart failure (HF) patients (PTs) who undergo heart transplantation (HT) or Destination Therapy Mechanical Circulatory Support (DT MCS) provide support to PTs before and after surgery, which may affect their own health-related quality of life (HRQOL). In SUSTAIN-IT, we previously reported that CG HRQOL was good at baseline (i.e., before HT and DT MCS surgery) and was impacted by CG comorbidities and CG anxiety. This report explores change in CG overall HRQOL, depression, and anxiety from baseline to 12 months after HT or DT MCS surgery. Methods: From 10/1/15-12/31/18, 13 U.S. centers enrolled 301 CGs of HF PTs: 193 awaiting HT (92 HT with MCS as a bridge to transplant [HT BTT] and 101 HT without MCS [HT non-BTT]), and 108 awaiting DT MCS. At baseline, 3, 6, and 12 months post HT or DT MCS surgery, CGs completed the following instruments: EQ-5D-3L (Visual Analog Scale [VAS]: 0 [worst] to 100 [best] imaginable health state), PHQ-8 (range=0-24; score ≥10=depressive symptoms requiring evaluation), and STAI-State (range=20-80, higher score=more anxiety). Analyses included unadjusted and baseline-adjusted linear regression models. Results: CGs were age 61.0±10.3 years; the majority were Caucasian (86%), female (86%), spouses (85%) of enrolled HF PTs. At baseline, CG EQ-5D-3L VAS and PHQ-8 average scores were 83.8 ± 13.99 (high) and 2.6 ± 2.85 (low), respectively, for the entire cohort. No significant interval changes in CG HRQOL and depressive symptoms were found within or between groups. DT MCS and HT non-BTT CG anxiety significantly decreased over time (baseline to 12 months) (Figure). Levels of CG anxiety were similar among all groups at 12 months after HT or DT MCS surgery. Conclusions: The demonstrated reduction in anxiety among CGs in the post-operative period provides clinicians with important information to share with CGs when PTs are considering surgical treatment options for HF.
Abstract 13350: Primary Payer Status Influences Management and Outcomes in Non-ST Elevation Myocardial Infarction
Authors: Viral K Desai, Vikas Singh, Saraschandra Vallabhajosyula
Journal: Circulation (2020)

Introduction: Multiple previous studies have shown that insurance status of the patient impacts the management and overall outcomes of patients presenting with acute myocardial infarction. There are limited data on the impact of primary payer status in patients with non ST segment elevation myocardial infarction (NSTEMI). Hypothesis: Primary payer status influences management and overall outcomes independent of the clinical and hospital-based characteristics in NSTEMI patients. Methods and Results: Adult (&gt;18 years) NSTEMI admissions were identified using the National Inpatient Sample database (2000-2017). Expected primary payer was classified into Medicare, Medicaid, private, uninsured, and others. Outcomes of interest included in-hospital mortality, use of coronary angiography, early coronary angiography and percutaneous coronary intervention (PCI), resource utilization, and discharge disposition. Of the 7,290,565 NSTEMI admissions, Medicare, Medicaid, private, uninsured, and other insurances were noted in 62.9%, 6.1%, 24.1%, 4.6%, and 2.3%, respectively. Compared to others, the Medicare cohort was older (76 vs. 53-60 years), more often female (48% vs. 25-44%), of white race, and with higher comorbidity (all p &lt;0.001). The Medicare cohort had higher in-hospital mortality (5.6%) compared to the other groups (1.9-3.4%), p &lt;0.001. In a multivariable analysis (Medicare referent), in-hospital mortality was higher in other (adjusted odds ratio (aOR) 1.15 [95% confidence interval {CI} 1.11-1.19]; p &lt;0.001), and lower in Medicaid (aOR 0.95 [95% CI 0.92-0.97]; p &lt;0.001), private (aOR 0.77 [95% CI 0.75-0.78]; p &lt;0.001) and uninsured cohorts (aOR 0.97 [95% CI 0.0.94-1.00]; p =0.06). Coronary angiography (overall 52% vs. 65-74%; early 15% vs. 22-27%) and PCI (27% vs. 35-44%) were used less frequently in the Medicare population. The Medicare population had longer lengths of hospital stay, lowest hospitalization costs and fewer discharges to home. Conclusions: Compared to other types of primary payers, NSTEMI admissions with Medicare insurance had lower use of coronary angiography and PCI and higher in-hospital mortality.
Fast-Trk(B)ing the mechanism of antidepressants
Authors: Jacinta N. Conroy, Dhanisha J. Jhaveri, Elizabeth J. Coulson
Journal: Neuron (2021)

The mechanism by which antidepressants elicit clinical improvements has proven elusive. In a recent publication in Cell, Casarotto et al. (2021) reveal a surprising direct interaction between antidepressants and TrkB. This link provides an important mechanistic insight into synaptic remodeling that may assist in the design of improved antidepressant therapeutics.
Abstract 13055: Impact of New Pacing Requirement on Echocardiographic Outcomes After Transcatheter Aortic Valve Replacement With Sapien-3 Valve
Authors: Yasser Sammour, Rama D Gajulapalli, Hassan Mehmood Lak, Sanchit Chawla, Arnav Kumar, Kimi Sato, Kinjal Banerjee, Lars G Svensson, James J Yun, Zoran B Popovic, Khaldoun Tarakji, Oussama M Wazni, Grant W Reed, Rishi Puri, Amar Krishnaswamy, Samir R Kapadia
Journal: Circulation (2020)

Introduction: New permanent pacemaker (PPM) requirement has been linked with left ventricular dysfunction after TAVR. Objective: We sought to study the impact of new PPM on echocardiographic outcomes after TAVR with SAPIEN-3 (S3) valve. Methods: We included consecutive patients who underwent TAVR with S3 valve at the Cleveland Clinic between April 2015 and December 2018. Patients with prior PPM were excluded. Echocardiograms were reviewed to determine left ventricular ejection fraction (LVEF), left ventricular end diastolic volume index (LVEDVi), left ventricular end systolic volume index (LVESVi), left ventricular dimension during diastole (LVDd), posterior wall thickness during diastole (PWTd), interventricular septum during diastole (IVSd), right ventricular systolic pressure (RVSP), inferior vena cava (IVC) diameter and tricuspid regurgitation (TR) grade. Results: Among 886 patients, the rate of 30-day PPM was 10.2%. Baseline LVEF was similar between new PPM and no PPM (55.4 ± 12.7% vs. 57.2 ± 11.2%; p = 0.188). There were no differences in the other studied echocardiographic parameters at baseline. Among patients with new PPM, LVEF was lower at both 30 days (54.4 ± 11.3% vs. 58.4 ± 10.1%; p = 0.001) and 1 year (54.2 ± 12% vs. 59.1 ± 11.3%; p = 0.009) compared to no PPM with Δ LVEF -0.9% vs. +1.4%; p = 0.023. There were no differences in LVEDVi (52 ± 20.8 vs. 48.3 ± 17.6; p = 0.186) at 1 year. LVESVi was higher with new PPM (24.8 ± 16.1 vs. 20.2 ± 10.9; p = 0.038). However, Δ LVESVi was similar between the 2 groups (-1.6 vs. -2.6; p = 0.517). There were no differences in RVSP (38.9 ± 14.1 vs. 40 ± 14; p = 0.58). LVIDd, PWTd, IVSd and IVC diameter also did not show variations whether patients were paced or not. Moderate to severe TR rates were similar as well (17.7% vs. 21.5%; p = 0.407). Conclusion: Among S3 TAVR recipients, new pacing requirement had a detrimental impact on LVEF at both 30 days and 1 year. However, it did not seem to affect the other studied echocardiographic outcomes after TAVR.
Disclosure of Presidential Health Information
Authors: John G. Sotos
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MEN 2Bの皮膚症状としてのER/PR陽性表皮向性原発性皮膚エクリン癌
Authors: P Aung Phyu, Mahalingam Meera, L Cummins Deborah, Y Ballester Leomar, Abdullaev Zied, D Pack Svetlana
Journal: Journal of the American Academy of Dermatology (2013)
More Effectiveness of Calcium-Channel Blockers in Primary Prevention of Acute Myocardial Infarction in Japanese Smokers
Authors: Yagi Hidenori, Aoyama Naofumi, Hongoh Kenichi, Kawai Makoto, Nojiri Ayumi, Kayama Yosuke, Morimoto Satoshi, Fujii Shinya, Nakane Tokiko, Taniguchi Ikuo, Yoshimura Michihiro
Journal: Circulation (2011)
CANCER STEM CELL MARKER EXPRESSING CELL POPULATION IN TWO CLONALLY RELATED, MORPHOLOGICALLY AND BIOLOGICALLY DISTINCT HUMAN HEPATOCELLULAR CARCINOMA CELL LINES ESTABLISHED FROM A SINGLE NODULE
Authors: Kusano H, Sanada S, Tanikawa K, Nakashima O, Ogasawara S, Akiba J, Yano H
Journal: Hepatology (2010)
Abstract 13403: Relationship Between Body Mass Index and In-hospital Outcomes After Percutaneous Coronary Intervention Among Patients With Acute Myocardial Infarction: A National In-Patient Analysis
Authors: Habeeb O Sanni, Oseiwe B Eromosele, Keziah E Aibangbee, Adedotun Ogunsua, Vivian N Chukwuma, Chiamaka S Diala, Abdulkareem O Lukan, Oluwafisayo S Fasanmi, Olakanmi Olagoke, Hawa O Abu, Efehi Igbinomwanhia
Journal: Circulation (2020)

Background: Body mass index (BMI), has been shown to be related to major adverse cardiovascular events, and overall mortality after percutaneous coronary intervention (PCI). However, the relationship between BMI, and important cardiovascular outcomes, as well as healthcare utilization have not been extensively explored in a national sample. Objectives: Examine the relationship between BMI and in-hospital mortality, cardiogenic shock, cardiac arrest, length of hospital stay (LOS), and cost of hospitalization. Methods: Adults who had a primary diagnosis of Acute Myocardial Infarction (AMI) who underwent a PCI were identified from the 2016 and 2017 National Inpatient Sample using ICD10 codes. BMI was classified BMI into: &lt;20 kg/m 2 , 20-29.9 kg/m 2 (reference), 30-34.9 kg/m 2 (Obesity class I), 35-39.9 kg/m 2 (Obesity class II) and ≥40 kg/m 2 (Obesity class III). Weighted multivariable logistic and linear regression models were used as appropriate. Results: Among 22,953 patients who had AMI and PCI done with reported BMI, 67.9% were male, and 76.2% were Non-Hispanic White. Compared to the reference group, obesity class I, II and III, showed an incremental higher odd of mortality, while patients with BMI &lt;20 kg/m 2 had non-significant lower odds of mortality (Table). Obesity class I and II had lower odds of cardiogenic shock compared to the reference group, while those in the extremes i.e. &lt;20 kg/m 2 and ≥40 kg/m 2 showed no significant difference (Table).The odds of cardiac arrest were not significantly different across the various BMI categories (Table). Obesity class III patients had significantly higher mean LOS and cost of hospitalization compared to the reference group (Table). Conclusion: Our study highlights the relationship between BMI and important clinical outcomes after PCI. These findings buttress the need for healthcare providers to identify high risk patients for worse outcomes after PCI and institute targeted interventions for improved clinical outcomes.
Abstract 15722: Proton Pump Inhibitors and Risk of Myocardial Infarction: A Systematic Review and Meta-analysis
Authors: Ahmed Ullah Mishuk, Shahariar Mohammed Fahim, Richard Hansen, Li Chen, Philippe Gaillard, Salisa Westrick, Jingjing Qian
Journal: Circulation (2020)

Introduction: Proton Pump Inhibitors (PPIs) are generally considered safe, but recent evidence suggests otherwise. Objective: This systematic review and meta-analysis assessed the association between PPIs and the risk of myocardial infarction (MI), using both clinical trials and observational studies. Methods: A systematic search was performed in December 2019 to retrieve all potential studies using PubMed, PsycInfo, International Pharmaceutical Abstracts, Web of Science, and Clinicaltrials.gov. This search initially identified any published studies describing any adverse event (AE) or outcomes related to PPI. Records were included in this study if 1) studies were published in English, 2) study design was clinical trials or observational studies, 3) PPI use was the exposure or treatment, and 4) study outcome was the incidence of MI. Two researchers independently reviewed all identified records, performed full article review, extracted data into structured evidence table, and conducted quality assessment using Newcastle-Ottawa Scale and Quality Assessment Tool for Quantitative Studies. Meta-analysis was performed using the RStudio software to assess the risk of MI with PPI use. Results: A total of 4,507 abstracts meeting the inclusion criteria were identified, and 20 full articles were included in this study, among which 10 were cohort, 3 were case-control, 3 were RCT post-hoc analysis, and 4 were RCT studies. The pooled Odds Ratio (OR)=1.40 with 95% CI=1.20-1.63 for all studies indicated the presence of an association between PPI use and increased risk of MI compared to PPI non-users. Meta-analysis found a similar association between PPI use and increased risk of MI in observational studies (OR=1.40; 95% CI=1.20, 1.64) but no association (OR=0.90; 95% CI=0.47, 1.73) in RCT-studies. Heterogeneity was high (I 2 &gt; 75%) for all analyses except for RCTs (I 2 =0%). Conclusion: Although our meta-analysis identified the association between PPI use and increased risk of MI, results from RCTs did not agree with observational studies. Due to the mixed findings by study designs and high variation of heterogeneity among studies, the pharmacovigilance system should evaluate different levels of evidence to support decision making in safety of drug products.
リポプロテイン(a)は血管内超音波検査で脂質プール像が梗塞冠動脈に存在することの独立予知因子である
Authors: Furukawa Kiyotaka, Tani Shigemasa, Watanabe Ikuyoshi, Kikushima Kimio, Watanabe Kazuhiro, Anazawa Takeo, Kawamata Hirofumi, Tachibana Eizo, Furuya Shingo, Takahashi Hiroshi, Iida Kiyoshi, Nomoto Kazumiki, Fujii Takeshi, Miyamoto Takashi, Washio Takehiko, Niizuma Shinichiro, Kumabe Narimichi, Nagao Ken, Kanmatsuse Katsuo, Kushiro Toshio
Journal: Circulation (2007)
Abstract 14808: Acute Kidney Injury and Adverse Outcomes in Patients Undergoing Right Heart Catheterization versus Patients Undergoing Right and Left Heart Catheterization and Coronary Angiography
Authors: Annette Min, Sumon Roy, Melissa Wasilewski, Ravi Choxi, Robert A Perera, Ion S Jovin
Journal: Circulation (2020)

Background: Contrast induced nephropathy (CIN), or contrast-induced acute kidney injury is considered a complication of intravascular administration of iodinated contrast material. However, more recent studies have challenged the reported incidence of contrast nephropathy. We compared the incidence of acute kidney injury and of nephropathy at 3 months in patients undergoing only right heart catheterization (RHC) to patients undergoing right and left heart catheterization (R&amp;LHC) and coronary angiography. Methods and Results: We studied 1779 consecutive patients at a Veterans Administration Medical Center, of which 869 underwent only RHC, which does not involve the administration of iodinated contrast media, and 910 patients who underwent R&amp;LHC and coronary angiography. Creatinine values at 72 hours after the respective procedure were available in 938 patients and creatinine values at 3 months were available in 1246 patients. The incidence of acute kidney injury (defined as an increase in serum creatinine of 0.5 mg/dL or 25% compared to baseline) at 3 days was 34 (7.5%) in the RHC group and 46 (9.5%) in the R&amp;LHC group (P=0.31). The incidence of nephropathy at 3 months was 89 (15.6%) in the RHC group and 113 (12.2%) in the R&amp;LHC group (P=0.15). On multivariable analysis including adjustment for a propensity score, CIN at 3 days was not significantly associated with R&amp;LHC (odds ratio (OR) 1.02, 95% confidence interval (CI) 0.98-1.05; P=0.56) and neither was nephropathy at 3 months (OR 1.01, 95% CI 0.98-1.04; P=0.22). Patients undergoing R&amp;LHC had a lower mortality at 12 months (hazard ratio 0.57, 95% CI 0.43-0.77; P&lt;0.001). Conclusions: The incidence of acute kidney injury was not significantly different in patients undergoing RHC compared to patients undergoing R&amp;LHC and coronary angiography, even though the former received no contrast dye. The incidence of nephropathy at 3 months was also not significantly different between the two groups while mortality was significantly lower in the group of patients undergoing R&amp;LHC. This suggests that serum creatinine is a nonspecific diagnostic marker for contrast induced-kidney injury and that long-term outcomes are not associated with the administration of contrast in this population.
Data discrepancies and substandard reporting of interim data of Sputnik V phase 3 trial
Authors: Enrico M Bucci, Johannes Berkhof, André Gillibert, Gowri Gopalakrishna, Raffaele A Calogero, Lex M Bouter, Konstantin Andreev, Florian Naudet, Vasiliy Vlassov
Journal: The Lancet (2021)