tbuckley/cabot-search huggingface dataset:
Development and Characterization of Gelatin‐Norbornene Bioink to Understand the Interplay between Physical Architecture and Micro‐Capillary Formation in Biofabricated Vascularized Constructs (Adv. Healthcare Mater. 2/2022)
Authors: Bram G. Soliman, Gretel S. Major, Pau Atienza‐Roca, Caroline A. Murphy, Alessia Longoni, Cesar R. Alcala‐Orozco, Jelena Rnjak‐Kovacina, Debby Gawlitta, Tim B. F. Woodfield, Khoon S. Lim
Journal: Advanced Healthcare Materials (2022)

3D Bioprinting The crosstalk between cells during microcapillary formation is highlighted in article 2101873 by Khoon S. Lim and co-workers. Mesenchymal stromal cells (red) building bridges to allow endothelial cells (green) to cross spatial gaps in biofabricated constructs for rapid vascularisation. Providing the right microenvironment is key to support cell-driven microcapillary formation.
The UK’s immigration plans threaten the health outcomes of asylum seekers and refugees
Authors: Matteo Besana, Yusuf Ciftci, Thabo Makuyana
Journal: BMJ (2022)

The Nationality and Borders Bill making its way through UK Parliament has received severe criticism in the past few months, 1 but there has been little discussion of its implications for the health of people seeking refugee protection in the UK.Priti Patel, the home secretary, has said that the main motivation behind this bill is to fix an asylum system that is broken.Yet the system was never broken, it actually did and is still doing what it was designed to do: to create a hostile environment for people seeking refuge.This bill will be the latest addition to a series of policies that restrict people's access to asylum and ensuing ability to lead meaningful lives in UK communities.It will also prevent people in vulnerable circumstances from accessing essential health and wellbeing services.We think that two outcomes of the bill in particular will have a harmful impact on health: its creation of more people with temporary immigration statuses and the planned greater use of institutional accommodation for those seeking asylum.
Biocompatibility and degradation comparisons of four biodegradable copolymeric osteosynthesis systems used in maxillofacial surgery: A goat model with four years follow-up
Authors: Barzi Gareb, Nico B. van Bakelen, Léon Driessen, Pieter Buma, Jeroen Kuipers, Dirk W. Grijpma, Arjan Vissink, Ruud R.M. Bos, Baucke van Minnen
Journal: Bioactive Materials (2022)

Applying biodegradable osteosyntheses avoids the disadvantages of titanium osteosyntheses. However, foreign-body reactions remain a major concern and evidence of complete resorption is lacking. This study compared the physico-chemical properties, histological response and radiographs of four copolymeric biodegradable osteosynthesis systems in a goat model with 48-months follow-up. The systems were implanted subperiosteally in both tibia and radius of 12 Dutch White goats. The BioSorb FX [poly(70LLA-co-30DLLA)], Inion CPS [poly([70-78.5]LLA-co-[16-24]DLLA-co-4TMC)], SonicWeld Rx [poly(DLLA)], LactoSorb [poly(82LLA-co-18GA)] systems and a negative control were randomly implanted in each extremity. Samples were assessed at 6-, 12-, 18-, 24-, 36-, and 48-month follow-up. Surface topography was performed using scanning electron microscopy (SEM). Differential scanning calorimetry and gel permeation chromatography were performed on initial and explanted samples. Histological sections were systematically assessed by two blinded researchers using (polarized) light microscopy, SEM and energy-dispersive X-ray analysis. The SonicWeld Rx system was amorphous while the others were semi-crystalline. Foreign-body reactions were not observed during the complete follow-up. The SonicWeld Rx and LactoSorb systems reached bone percentages of negative controls after 18 months while the BioSorb Fx and Inion CPS systems reached these levels after 36 months. The SonicWeld Rx system showed the most predictable degradation profile. All the biodegradable systems were safe to use and well-tolerated (i.e., complete implant replacement by bone, no clinical or histological foreign body reactions, no [sterile] abscess formation, no re-interventions needed), but nanoscale residual polymeric fragments were observed at every system's assessment.
Impact of intensive lifestyle intervention on gut microbiota composition in type 2 diabetes: a <i>post-hoc</i> analysis of a randomized clinical trial
Authors: Shaodong Wei, Asker Daniel Brejnrod, Urvish Trivedi, Martin Steen Mortensen, Mette Yun Johansen, Kristian Karstoft, Allan Arthur Vaag, Mathias Ried-Larsen, Søren Johannes Sørensen
Journal: Gut Microbes (2021)

Type 2 diabetes (T2D) management is based on combined pharmacological and lifestyle intervention approaches. While their clinical benefits are well studied, less is known about their effects on the gut microbiota. We aimed to investigate if an intensive lifestyle intervention combined with conventional standard care leads to a different gut microbiota composition compared to standard care alone treatment in individuals with T2D, and if gut microbiota is associated with the clinical benefits of the treatments. Ninety-eight individuals with T2D were randomized to either an intensive lifestyle intervention combined with standard care group (N = 64), or standard care alone group (N = 34) for 12 months. All individuals received standardized, blinded, target-driven medical therapy, and individual counseling. The lifestyle intervention group moreover received intensified physical training and dietary plans. Clinical characteristics and fecal samples were collected at baseline, 3-, 6-, 9-, and 12-month follow-up. The gut microbiota was profiled with 16S rRNA gene amplicon sequencing. There were no statistical differences in the change of gut microbiota composition between treatments after 12 months, except minor and transient differences at month 3. The shift in gut microbiota alpha diversity at all time windows did not correlate with the change in clinical characteristics, and the gut microbiota did not mediate the treatment effect on clinical characteristics. The clinical benefits of intensive lifestyle and/or pharmacological interventions in T2D are unlikely to be explained by, or causally related to, changes in the gut microbiota composition.
Abstract P213: Change in Diet Quality and Risk of Incident Diabetes: The Atherosclerosis Risk in Communities Study
Authors: Zhe Xu, Lyn M Steffen, Elizabeth Selvin, Casey M Rebholz
Journal: Circulation (2018)

Introduction: Despite the well-established association between diet and chronic disease risk, there is limited evidence on the association between diet change and long-term risk of diabetes in a community-based setting. Hypothesis: Decline in diet quality is associated with an increased risk for incidence of diabetes in the Atherosclerosis Risk in Communities (ARIC) Study. Methods: We included 8285 ARIC participants who had complete dietary intake assessments by food frequency questionnaire (FFQ) at both visits 1 (1987-1989) and 3 (1993-1995) and had no prevalent diabetes, cardiovascular disease, or cancer prior to visit 3. Change in diet quality was assessed using the Healthy Eating Index (HEI)-2015 and the Alternative HEI (AHEI)-2010 scores calculated at the two study visits. Change in scores was classified into five categories from moderate/large decrease to moderate/large increase. We used adjusted Cox models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association between HEI-2015/AHEI-2010 score changes and incidence of diabetes, which is defined using doctor diagnosis, medication use, or elevated glucose. Results: There were 2,136 cases of incident diabetes during a median of 18.05 years of follow-up (124,639 person-years). For HEI-2015, there were no statistically significant association between dietary score change and diabetes risk, comparing the five categories of changes (adjusted HRs and 95% CIs for the five categories from decrease to increase were 1.06 [0.90-1.25],1.04 [0.90-1.21],1.00 (ref.), 0.91 [0.79-1.05], 1.04 [0.91-1.20]). Similar trends were found in AHEI-2010 scores changes, but for the moderate to large decrease group, the decrease in dietary scores was associated with a higher diabetes risk (HR 1.23, 95%CI 1.03 to 1.46), compared to the stable group. Conclusion: The results suggest that deterioration of diet quality is associated with a higher risk of diabetes.
Diagnostic implications of circulating oxidized low density lipoprotein levels as a biochemical risk marker of atherosclerotic disease Toru Suzuki, Hiroaki Kohno, Shun-ichi Toshima, Akira Hasegawa, Masahiko Kurabayashi, Ryozo Nagai. University of Tokyo, Tokyo, Japan, Gunma University, Maebashi, Japan
Journal: Journal of the American College of Cardiology (2001)
A Second Example of Anti-Xga
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Review of the British Thoracic Society Winter Meeting 2018, 5–7 December 2018, London, UK
Authors: Amanda T Goodwin, Aran Singanayagam, Gisli Jenkins
Journal: Thorax (2019)

Introduction The Winter Meeting of the British Thoracic Society (BTS) is a platform for the latest clinical and scientific research in respiratory medicine. This review summarises some key symposia and presentations from the BTS Winter Meeting 2018. Methods Key symposia and research presentations from the BTS Winter Meeting 2018 were attended and reviewed by the authors. Results The seminal messages from the latest clinical and scientific research covering a range of respiratory diseases, including asthma, interstitial lung disease, infection, cystic fibrosis, pulmonary vascular disease, pleural disease and occupational lung disease were summarised in this review. Discussion The BTS Winter Meeting 2018 brought the very best of respiratory research to an audience of scientists, physicians, nurses and allied health professionals. The Winter Meeting continues to be a highlight of the UK respiratory research calendar, and we look forward to the next meeting in December 2019.
Expanded Polytetrafluoroethylene Grafts in Reconstructive Arterial Surgery
Authors: Frank J. Veith
Journal: JAMA (1978)

One hundred ten arterial reconstructions, including several new and extended bypasses, were performed with polytetrafluoroethylene (PTFE) grafts and were observed for three to 16 months. Patency rates were 100% with 15 bypasses to the femoral artery, 95% with 66 bypasses to the popliteal artery, and 76% with 29 bypasses to the arteries of the leg and foot. These encouraging preliminary results justify continued use and evaluation of PTFE as an arterial prosthesis. (<i>JAMA</i>240:1867-1869, 1978)
SUBJECT INDEX
Journal: Circulation Research (1965)

effects of imposed pacing, 460 Purkinje fibers and ventricular muscle cells compared, 259 Actomyosin, ATPase activity and effects of histones, 555 Adenine nucleotides, effects on glucose utilization in the heart, 135 Adenosine triphosphatase, actomyosin and effects of histones, 555 Adenosine triphosphate (ATP), inhibition of cardiac glucose utilization; microsomes, 135 Adrenal cortex, aldosterone secretion
Urodynamics
Authors: Saul Boyarsky
Journal: JAMA (1971)

The authors, a well-known practicing urologist and a fluids engineer, though not associated with a major university center, have produced a book worthy of any academic institution. This volume is a significant contribution to bladder physiology and to the growing field of urodynamics. Keitzer and Huffman have developed the voiding audiograph as a semiquantitive timed recording of the sound of urination. The "piddle pattern" is an automated and refined record of the urinary stream, which is itself an underutilized clinical datum. Interestingly and importantly the test is a noninterfering urodynamic technique. As a measure of stream energy, its potential accuracy is claimed to be greater than those based on pressure or flow measurements; this contention remains to be confirmed. The authors have used the audiograph in clinical surveys for the diagnosis and follow-up of adult and pediatric urologic patients, in mass surveys and in evaluating the results of urethral and
Typhoid Fever.
Authors: R. Sayre Harnden
Journal: JAMA (1896)

Waverly, N. Y., July 20, 1896. <h3>To the Editor:</h3> —Although much has been written upon the subject of typhoid fever of late, it seems important that the antiseptic treatment should be fully and extensively discussed. If the results obtained by many observers be verified and sustained by extensive experience, then indeed we have made wonderful strides in the management of this formidable disease. My experience with typhoid fever during the past thirty-five years has convinced me that it is a self-limited condition or disease, and it seems self-evident that many people are immune to its toxic elements or the condition styled auto-infection, and also the so-called "mixed infection," recovery taking place after the gravest symptoms and without treatment. Many persons seem to be immune against typhoid fever, leading some observers to conclude that the disease is not infectious or contagious. Now does it not follow, if this be true, that
Association of Cutaneous Immune-Related Adverse Events With Increased Survival in Patients Treated With Anti–Programmed Cell Death 1 and Anti–Programmed Cell Death Ligand 1 Therapy
Authors: Kimberly Tang, Jayhyun Seo, Bruce C. Tiu, Thomas K. Le, Vartan Pahalyants, Neel S. Raval, Pearl O. Ugwu-Dike, Leyre Zubiri, Vivek Naranbhai, Mary Carrington, Alexander Gusev, Kerry L. Reynolds, Nicole R. LeBoeuf, Maryam M. Asgari, Shawn G. Kwatra, Yevgeniy R. Semenov
Journal: JAMA Dermatology (2022)

Despite the efficacy of immune checkpoint inhibitors (ICIs), cutaneous immune-related adverse events (cirAEs) occur in 20% to 40% of all treated patients. To our knowledge, little is known about the predictive value of these cutaneous eruptions and their subtypes regarding cancer survival.To determine the association of developing cirAEs following treatment with anti-programmed cell death 1 (PD-1) or anti-programmed cell death ligand 1 (PD-L1) therapy with patient survival.This retrospective cohort study used data from the TriNetX Diamond Network, a database of health records and claims data from more than 200 million US and European patients, to conduct a population-level cohort analysis. The study included 7008 eligible patients who developed cirAEs after treatment with anti-PD-1 or anti-PD-L1 therapy for malignant neoplasms of digestive organs, bronchus or lung, melanoma of skin, and urinary tract who were identified through the TriNetX Diamond Network along with 7008 matched controls.Development of cirAEs within 6 months following anti-PD-1 or anti-PD-L1 therapy.A 6-month analysis using a Cox proportional hazards model was performed to determine the association of cirAEs with overall survival after adjusting for demographic characteristics, cancer type, and cancer stage.A total of 7008 patients (3036 women [43.3%]; mean [SD] age, 68.2 [11.2] years) were matched to 7008 (3044 women [43.4%]; mean [SD] age, 68.3 [11.1] years) controls. Pruritus (hazard ratio [HR], 0.695; 95% CI, 0.602-0.803; P < .001), drug eruption (HR, 0.755; 95% CI, 0.635-0.897; P = .001), xerosis (HR, 0.626; 95% CI, 0.469-0.834; P = .001), nonspecific rashes (HR, 0.704; 95% CI, 0.634-0.781; P < .001), and appearance of any cirAE (HR, 0.778; 95% CI, 0.726-0.834; P < .001) were significantly protective of mortality using a Benjamini-Hochberg correction with a significance level of .05. Additionally, psoriasis (HR, 0.703; 95% CI, 0.497-0.994; P = .045) and lichen planus/lichenoid dermatitis (HR, 0.511; 95% CI, 0.279-0.939; P = .03) were significant. Eczematous dermatitis (HR, 0.612; 95% CI, 0.314-1.195), vitiligo (HR, 0.534; 95% CI, 0.254-1.123), bullous pemphigoid (HR, 0.524; 95% CI, 0.140-1.956), and Grover disease (HR, 0.468; 95% CI, 0.115-1.898) were all associated with strong protective clinical effects.The results of this cohort study suggest that the development of cirAEs is strongly associated with response to ICI therapy and patient survival.
1972 PROGRAM AMERICAN SOCIETY FOR CLINICAL INVESTIGATION, INC. 64TH ANNUAL MEETING
Authors: Pennsylvania Room, Haddon Hall, G Rama Reddy, D Baxter, Guy Rousseau, Stephen Higgins, Gordon Tomkins, San Francisco, Robert Lewis, Janine Andre, Care Walter, Robin Roberts, Michael Gent, David Sackett, John Sibley, L Dow, D Kacian, M Terada, S Metafora, S Spiegelman, P Marks, Stephen Achuff, Lawrence Griffith, J O', Neal Humphries, C Conti, Herbert Levine, Dean Mason, Sunday Afcr, Irwin Freedberg, Ruth Freinkel, B Tomasi, York Afcr, R Syl- Vester, M Attais, N Talal, D Tuffanelli, Calif Afcr, Cytochalasin Keratinocytes, Stephanie Mcguire, John Voorhees, Elizabeth Duell, William Kelsey, Emmet Hayes, Ann Arbor, Mich Afcr, Mar- Tin Hashimoto, Tenn Memphis, New York, Intercellular Epidermal, Concanavalin Michael, L Nieland, Nancy Nieland, Stephen Krane, William Geme, E Boyd, Patrick Mulrow, New Haven, Steven Schenker, M Grundy, Allan Metzger, Ronald Adler, Manl Juan, R Malagelada, Vay Go, Eugene Dimagno, William Summerskill, E Wollaeger
Journal: Journal of Clinical Investigation (1972)
Correction: KRAS Inhibitor Resistance in <i>MET</i>-Amplified <i>KRAS</i>G12C Non–Small Cell Lung Cancer Induced By RAS- and Non–RAS-Mediated Cell Signaling Mechanisms
Authors: Shinichiro Suzuki, Kimio Yonesaka, Takeshi Teramura, Toshiyuki Takehara, Ryoji Kato, Hitomi Sakai, Koji Haratani, Junko Tanizaki, Hisato Kawakami, Hidetoshi Hayashi, Kazuko Sakai, Kazuto Nishio, Kazuhiko Nakagawa
Journal: Clinical Cancer Research (2022)

In the original version of this article (1), the “Crizotinib” label in Fig. 4F is incorrect; the label should be “Selumetinib”. The error has been corrected in the latest online HTML and PDF versions of the article. The publisher regrets the error.
Update Alert 7: Risks and Impact of Angiotensin-Converting Enzyme Inhibitors or Angiotensin-Receptor Blockers on SARS-CoV-2 Infection in Adults
Authors: Katherine Mackey, Devan Kansagara, Kathryn Vela
Journal: Annals of Internal Medicine (2021)

searched MEDLINE (Ovid) weekly from 27 October to
Gastric Ulcer
Authors: Stephen L. Goldman
Journal: JAMA (1977)

GASTRIC metastases are frequently found during autopsy of patients with malignant melanoma. However, few of these have been diagnosed during life. The following report is concerned with a patient with clinical and radiological findings suggestive of gastric ulcer. A definitive diagnosis of metastatic melanoma was made only six weeks later, when disseminated disease elsewhere was already present. <h3>Report of a Case</h3> A 46-year-old, essentially healthy laborer complained to his family physician of crampy midepigastric pain, weakness, and weight loss. An upper-gastrointestinal radiological study was performed and showed an active gastric ulcer. Ulcer diet, antacids, and anticholinergics were prescribed and were followed by transient relief. Within six weeks of onset, bluish subcutaneous nodules developed on the anterior aspect of the patient's chest and arms. At the same time a pathological fracture of the spinous process of C-7 and melanuria developed. Biopsy of one subcutaneous nodule led to the histologic diagnosis of
HIGH FREQUENCY CURRENTS AND ROENTGENOTHERAPY IN VESICAL TUMORS
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Strange Case of the Doctored Reprint
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>Erratum:</i> Vol. 69, No. 49
Authors: Jessica Arrazola, Matthew Masiello, Sujata Joshi, Adrian Dominguez, Amy Poel, Crisandra Wilkie, Jonathan Bressler, Joseph Mclaughlin, Jennifer Kraszewski, Kenneth Komatsu, ; Xandy, Peterson Pompa, Megan Jespersen, Gillian Richardson, Nicholas Lehnertz, Pamela Lemaster, Britney Rust, Alison Metobo, Brooke Doman, David Casey, Jessica Kumar, Alyssa Rowell, Tracy Miller, Mike Mannell, ; Naqvi, Aaron Wendelboe, Richard Leman, Joshua Clayton, Bree Barbeau, Samantha Rice, Samantha Rolland, Victoria Warren-Mears, Abigail Echo-Hawk, Andria Apostolou, Michael Landen, Samantha The
Journal: MMWR Morbidity and Mortality Weekly Report (2021)
MA09.03 Comparative Effectiveness of a Lymph Node Collection Kit Versus ‘Heightened Awareness’ on Lung Cancer Surgery Quality and Outcomes
Authors: M. Ray, M. Smeltzer, N. Faris, O. Akinbobola, C. Fehnel, Y. Lee, M. Meadows-Taylor, R. Osarogiagbon
Journal: Journal of Thoracic Oncology (2021)