tbuckley/cabot-search huggingface dataset:
Abstract 10023: Association of Systolic and Diastolic Blood Pressure with Age in Rural Indians
Authors: Aniket Inamdar
Journal: Circulation (2021)

Introduction: It is known from various studies that rising blood pressure is associated with increased cardiovascular risk. The increase in blood pressure with age is mostly associated with structural changes in the arteries. Studies from today’s industrialized world have shown change towards an increase in Blood Pressure (BP), possibly due to change in diet, reduction in exercise and increase in stress. Daily salt intake in Indians is very high compared to western population. A high salt diet may induce changes in the vascular smooth muscle cells resulting in collagen accumulation in the large artery walls and consequent increased arterial stiffness. Hypothesis: The main objective was to determine the association of systolic and diastolic blood pressure with age in rural Indians. Methods: 310 patients from age 30 to 85 years who visited our hospital in rural India from January 01,2021 to February 28,2021 were included in this study. Data were collected directly by measuring the systolic and diastolic blood pressure manually in comfortable sitting position. One way ANOVA, post hoc Tukey test and Pearson’s correlation test were used to analyze the data. Results: Statistical analysis showed that there was statistically significant positive correlation between age and systolic blood pressure ( p = 0.045 , r = 0.114). This study showed negative correlation between age and diastolic blood pressure ( p =0.124, r = - 0.087) but it was not statistically significant. This study shows that as age increases systolic BP increases. Conclusions: This study shows elevation of systolic blood pressure with increasing age in rural Indians. Data obtained during the Framingham Heart Study, which followed patients for 30 years, showed that systolic blood pressure (SBP) shows a continuous increase between the ages of 30 and 84 years or over. Diastolic blood pressure (DBP), however, has a varying pattern with ageing, increasing until the fifth decade and slowly decreasing from the age of 60 to at least 84 years of age. In the elderly, the most powerful predictor of risk is increased pulse pressure due to decreased diastolic and increased systolic blood pressure. To reduce the risk of cardiovascular events, adequate efforts are necessary to screen our population regularly for hypertension.
Sustained IGF-1 delivery ameliorates effects of chronic denervation and improves functional recovery after peripheral nerve injury and repair
Authors: Philip J. Hanwright, Chenhu Qiu, Jennifer Rath, Yang Zhou, Nicholas von Guionneau, Karim A. Sarhane, Thomas G.W. Harris, Gregory P. Howard, Harsha Malapati, Michael J. Lan, Sashank Reddy, Ahmet Hoke, Hai-Quan Mao, Sami H. Tuffaha
Journal: Biomaterials (2021)
Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells
Authors: Daniel Chauss, Tilo Freiwald, Reuben McGregor, Bingyu Yan, Luopin Wang, Estefania Nova-Lamperti, Dhaneshwar Kumar, Zonghao Zhang, Heather Teague, Erin E. West, Kevin M. Vannella, Marcos J. Ramos-Benitez, Jack Bibby, Audrey Kelly, Amna Malik, Alexandra F. Freeman, Daniella M. Schwartz, Didier Portilla, Daniel S. Chertow, Susan John, Paul Lavender, Claudia Kemper, Giovanna Lombardi, Nehal N. Mehta, Nichola Cooper, Michail S. Lionakis, Arian Laurence, Majid Kazemian, Behdad Afzali
Journal: Nature Immunology (2021)
Hypomethylating Agent (HMA) Therapy and Venetoclax (VEN) with FLT3 Inhibitor "Triplet" Therapy Is Highly Active in Older/Unfit Patients with FLT3 Mutated AML
Authors: Musa Yilmaz, Hagop Kantarjian, Nicholas J. Short, Marina Konopleva, Tapan M. Kadia, Courtney D. DiNardo, Gautam Borthakur, Naveen Pemmaraju, Abhishek Maiti, Elias J. Jabbour, Ghayas C. Issa, Nitin Jain, Koichi Takahashi, Koji Sasaki, Maro Ohanian, Guilin Tang, Sanam Loghavi, Keyur Patel, Guillermo Garcia-Manero, Michael Andreeff, Farhad Ravandi, Naval Daver
Journal: Blood (2021)
Mitofusin2 (MFN2) Preserves Mitochondrial Integrity and Function in Megakaryocytes and Platelets
Authors: Shancy P Jacob, Yasuhiro Kosaka, Seema Bhatlekar, Alexandra Moody, Victoria Moody, Emilia A Tugolukova, Grayson A Hull, Frederik Denorme, Bhanu Kanth Manne, Li Guo, Rhonda Souvenir, Alicia Eustes, Kelly B Hoerger, Neal D Tolley, Robert A. Campbell, Matthew T. Rondina, E. Dale Abel, Paul F. Bray, Andrew S. Weyrich, Jesse W Rowley
Journal: Blood (2021)
Enteroviruses and Type 1 Diabetes: Multiple Mechanisms and Factors?
Authors: Richard E. Lloyd, Manasi Tamhankar, Åke Lernmark
Journal: Annual Review of Medicine (2021)

Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by insulin deficiency and resultant hyperglycemia. Complex interactions of genetic and environmental factors trigger the onset of autoimmune mechanisms responsible for development of autoimmunity to β cell antigens and subsequent development of T1D. A potential role of virus infections has long been hypothesized, and growing evidence continues to implicate enteroviruses as the most probable triggering viruses. Recent studies have strengthened the association between enteroviruses and development of autoimmunity in T1D patients, potentially through persistent infections. Enterovirus infections may contribute to different stages of disease development. We review data from both human cohort studies and experimental research exploring the potential roles and molecular mechanisms by which enterovirus infections can impact disease outcome.
Immune Profiles of Myeloma Tumor Microenvironment May Predict Sensitivity or Resistance to Elotuzumab
Authors: David Noyes, Melissa Alsina, Kenneth H. Shain, Rachid Baz, Taiga Nishihori, Jose Ochoa, Jinming Song, Jongphil Kim, Alexandra Achille, Jason Brayer
Journal: Blood (2021)
A Real-World Evaluation of the Association between Elevated Blood Counts and Thrombotic Events in Polycythemia Vera (Analysis of Data from the REVEAL Study)
Authors: Aaron T. Gerds, Ruben A. Mesa, John M. Burke, Michael R. Grunwald, Brady Lee Stein, Robyn Scherber, Jingbo Yu, J.E. Hamer-Maansson, Stephen Oh
Journal: Blood (2021)
Abstract 9557: Prognostic Significance of Serum Chloride Level in Patients With Acute Decompensated Heart Failure with Preserved Ejection Fraction: Insights from Pursuit-hfpef Registry
Authors: Masahiro Seo, Takahisa Yamada, Yoshio Yasumura, Shungo Hikoso, Yohei Sotomi, Shunsuke Tamaki, Masamichi Yano, Takaharu Hayashi, Akito Nakagawa, Yusuke Nakagawa, Yasushi Sakata
Journal: Circulation (2021)

Backgrounds: Prognostic value of serum chloride level has been reported mainly in patients with heart failure with reduced ejection fraction. Therefore, the evidence regarding the prognostic value of serum chloride level in patients of heart failure with preserved ejection fraction (HFpEF) is limited. The aim of this study is to clarify the association of serum chloride level and outcomes in HFpEF patients with acute decompensated heart failure (ADHF). Methods and Results: Patients’ data were extracted from The Prospective mUlticenteR obServational stUdy of patIenTs with Heart Failure with Preserved Ejection Fraction (PURSUIT HFpEF) study, which is a prospective multicenter observational registry for ADHF-HFpEF in Osaka. We analyzed 870 patients who were enrolled in the study between June 2016 and March 2020, after exclusion of patients with in-hospital death, missing follow-up data, missing data of serum chloride level or on chronic dialysis therapy. The primary endpoint of this study was cardiac death. During a mean follow-up period of 1.8±1.0 years, a total of 82 patients reached the primary endpoint. On Cox multivariable analysis, serum chloride level (p=0.0018) was independently associated with cardiac death, whereas serum sodium level was no longer significant after multivariable adjustment of major confounders. Kaplan-Meier survival curve analysis demonstrated a significantly increased risk of cardiac death stratified by the tertile of serum chloride level (13% vs 10% vs 5%, p=0.0045). Conclusion: Serum chloride level was useful for the prediction of cardiac death in ADHF patients with preserved ejection fraction.
An In Vivo CRISPR Screening Platform to Identify New Therapeutic Targets in AML
Authors: Shan Lin, Clement Larrue, Nastassja K. Scheidegger, Bo Kyung A. Seong, Neekesh V Dharia, Caroline Wechsler, Guillaume Kugener, Amanda L Robinchaud, Amy Conway, Biniam Adane, Scott Younger, Federica Piccioni, Lynn Lee, Mark Wunderlich, Jerome Tamburini, Kimberly Stegmaier
Journal: Blood (2021)
First-in-Human Clinical Study of a Novel CD7-Targeted Chimeric Antigen Receptor (CAR)-T Cell Therapy for Refractory/Relapsed Mixed Phenotype Acute Leukemia (MPAL)
Authors: Xian Zhang, Junfang Yang, Jingjing Li, Yanze Shi, Yunchao Su, Ying Liu, Min Ba, Yan Wu, Wenqian Li, Jianqiang Li, Peihua Lu
Journal: Blood (2021)
ADAR1 Splicing Modulation As a Mechanism to Eradicate Immunologically Silent Leukemia Stem Cells
Authors: Leslie A Crews, Phoebe Mondala, Cayla Mason, Larisa Balaian, Wenxue Ma, Jessica Pham, Christina Wu, Peggy Wentworth, James La Clair, Michael Burkart, Catriona Jamieson
Journal: Blood (2021)
Outcomes for Patients with Late-Stage Mutant-<i>IDH2</i> (m <i>IDH2</i>) Relapsed/Refractory Acute Myeloid Leukemia (R/R AML) Treated with Enasidenib Vs Other Lower-Intensity Therapies in the Randomized, Phase 3 IDHentify Trial
Authors: Courtney D. DiNardo, Pau Montesinos, Andre C. Schuh, Cristina Papayannidis, Paresh Vyas, Andrew H. Wei, Amer M. Zeidan, Iryna Bluemmert, Xin Yu, Maroof Hasan, Patricia Martin-Regueira, Stephane de Botton
Journal: Blood (2021)
Targeting FOLR1 in High-Risk CBF2AT3-GLIS2 AML with Stro-002 FOLR1-Directed Antibody-Drug Conjugate
Authors: Quy Le, Jenny L. Smith, Thao T. Tang, Sommer Castro, Cynthia Nourigat-Mckay, LaKeisha Perkins, Benjamin J. Huang, Rhonda E. Ries, Amanda R. Leonti, Tiffany A. Hylkema, Laura Pardo, Cristina Abrahams, Kristin Bedard, Arturo Molina, Lisa Eidenschink Brodersen, Michael R. Loken, Soheil Meshinchi
Journal: Blood (2021)
Abstract 12935: Early Decongestive Therapy versus High-Flow Nasal Cannula in Preventing the Development of Adverse Clinical Events in Patients With Acute Cardiogenic Pulmonary Edema
Authors: Sang Yong Om, Junho Hyun, Kyung Hun Nam, Sun Hack Lee, Sang Eun Lee, Min-Seok Kim
Journal: Circulation (2018)

Introduction: There are scarce data about the role of decongestive therapy and high-flow nasal cannula (HFNC) in preventing reintubation and in-hospital mortality in patients with acute cardiogenic...
Hemoglobin Changes during Long-Lasting Frontline Treatment with Tyrosine-Kinase Inhibitors in Patients with Chronic Myeloid Leukemia
Authors: Roberto Latagliata, Ida Carmosino, Ambra Di Veroli, Emilia Scalzulli, Gioia Colafigli, Maria Cristina Scamuffa, Alessio Di Prima, Cinzia De Gregoris, Sara Pepe, Marco Mancini, Giulio Trapè, Maurizio Martelli, Robin Foa, Massimo Breccia
Journal: Blood (2021)
Global antibiotic consumption and usage in humans, 2000–18: a spatial modelling study
Authors: Annie J Browne, Michael G Chipeta, Georgina Haines-Woodhouse, Emmanuelle P A Kumaran, Bahar H Kashef Hamadani, Sabra Zaraa, Nathaniel J Henry, Aniruddha Deshpande, Robert C Reiner, Nicholas P J Day, Alan D Lopez, Susanna Dunachie, Catrin E Moore, Andy Stergachis, Simon I Hay, Christiane Dolecek
Journal: The Lancet Planetary Health (2021)

Antimicrobial resistance (AMR) is a serious threat to global public health. WHO emphasises the need for countries to monitor antibiotic consumption to combat AMR. Many low-income and middle-income countries (LMICs) lack surveillance capacity; we aimed to use multiple data sources and statistical models to estimate global antibiotic consumption.In this spatial modelling study, we used individual-level data from household surveys to inform a Bayesian geostatistical model of antibiotic usage in children (aged <5 years) with lower respiratory tract infections in LMICs. Antibiotic consumption data were obtained from multiple sources, including IQVIA, WHO, and the European Surveillance of Antimicrobial Consumption Network (ESAC-Net). The estimates of the antibiotic usage model were used alongside sociodemographic and health covariates to inform a model of total antibiotic consumption in LMICs. This was combined with a single model of antibiotic consumption in high-income countries to produce estimates of antibiotic consumption covering 204 countries and 19 years.We analysed 209 surveys done between 2000 and 2018, covering 284 045 children with lower respiratory tract infections. We identified large national and subnational variations of antibiotic usage in LMICs, with the lowest levels estimated in sub-Saharan Africa and the highest in eastern Europe and central Asia. We estimated a global antibiotic consumption rate of 14·3 (95% uncertainty interval 13·2-15·6) defined daily doses (DDD) per 1000 population per day in 2018 (40·2 [37·2-43·7] billion DDD), an increase of 46% from 9·8 (9·2-10·5) DDD per 1000 per day in 2000. We identified large spatial disparities, with antibiotic consumption rates varying from 5·0 (4·8-5·3) DDD per 1000 per day in the Philippines to 45·9 DDD per 1000 per day in Greece in 2018. Additionally, we present trends in consumption of different classes of antibiotics for selected Global Burden of Disease study regions using the IQVIA, WHO, and ESAC-net input data. We identified large increases in the consumption of fluoroquinolones and third-generation cephalosporins in North Africa and Middle East, and south Asia.To our knowledge, this is the first study that incorporates antibiotic usage and consumption data and uses geostatistical modelling techniques to estimate antibiotic consumption for 204 countries from 2000 to 2018. Our analysis identifies both high rates of antibiotic consumption and a lack of access to antibiotics, providing a benchmark for future interventions.Fleming Fund, UK Department of Health and Social Care; Wellcome Trust; and Bill & Melinda Gates Foundation.
Extracellular vesicles fail to trigger the generation of new cardiomyocytes in chronically infarcted hearts
Authors: Bruna Lima Correa, Nadia El Harane, Manon Desgres, Maria Perotto, Paul Alayrac, Chloé Guillas, Laetitia Pidial, Valérie Bellamy, Emilie Baron, Gwennhael Autret, Keirththana Kamaleswaran, Chloé Pezzana, Marie-Cécile Perier, José Vilar, Antonio Alberdi, Alain Brisson, Nisa Renault, Massimiliano Gnecchi, Jean-Sébastien Silvestre, Philippe Menasché
Journal: Theranostics (2021)

Background: Extracellular vesicles (EV) mediate the therapeutic effects of stem cells but it is unclear whether this involves cardiac regeneration mediated by endogenous cardiomyocyte proliferation. Methods: Bi-transgenic MerCreMer/ZEG (n = 15/group) and Mosaic Analysis With Double Markers (MADM; n = 6/group) mouse models underwent permanent coronary artery ligation and received, 3 weeks later, 10 billion EV (from human iPS-derived cardiovascular progenitor cells [CPC]), or saline, injected percutaneously under echo guidance in the peri-infarcted myocardium. Endogenous cardiomyocyte proliferation was tracked by EdU labeling and biphoton microscopy. Other end points, including cardiac function (echocardiography and MRI), histology and transcriptomics were blindly assessed 4-6 weeks after injections. Results: There was no proliferation of cardiomyocytes in either transgenic mouse strains. Nevertheless, EV improved cardiac function in both models. In MerCreMer/ZEG mice, LVEF increased by 18.3 ± 0.2% between baseline and the end-study time point in EV-treated hearts which contrasted with a decrease by 2.3 ± 0.2% in the PBS group; MADM mice featured a similar pattern as intra-myocardial administration of EV improved LVEF by 13.3 ± 0.16% from baseline whereas it decreased by 14.4 ± 0.16% in the control PBS-injected group. This functional improvement was confirmed by MRI and associated with a reduction in infarct size, the decreased expression of several pro-fibrotic genes and an overexpression of the anti-fibrotic miRNA 133-a1 compared to controls. Experiments with an anti-miR133-a demonstrated that the cardio-reparative effects of EV were partly abrogated. Conclusions: EV-CPC do not trigger cardiomyocyte proliferation but still improve cardiac function by other mechanisms which may include the regulation of fibrosis.
Rapid and Safe T Cell Immune Reconstitution By T Cell Progenitor Injection Following Haploidentical Transplantation for Severe Combined Immunodeficiency (SCID)
Authors: Despina Moshous, Elisa Magrin, Sarah Winter, Benjamin Fournier, Martin Castelle, Laurence Vendrame, Lucienne Chatenoud, Capucine Picard, Bénédicte Neven, Alessandra Magnani, Pierre Gaudeaux, Tayebeh-Shabi Soheili, Isabelle Andre, Laura Simons, Marina Cavazzana
Journal: Blood (2021)
KDM6 Demethylases Integrate DNA Repair Gene Regulation: Loss of KDM6A Sensitizes AML to PARP Inhibition and Potentiates with BCL2 Blockade
Authors: Liberalis Debraj Boila, Liqing Jin, Alex Murison, Subham K. Bandyopadhyay, Subhadeep Ghosh, Siva Sai Naga Anurag Muddineni, Andy G.X. Zeng, Sayantani Sinha, Shankha Subhra Chatterjee, Mayukh Biswas, Nathan Mbong, Olga I. Gan, Andrea Arruda, Wasim Shaikh, Anwesha Bose, Satyaki Bhowmik, Sayan Chakraborty, James A. Kennedy, Amanda Mitchell, Eric R. Lechman, Debasis Banerjee, Michael Milyavsky, Mark D. Minden, John E. Dick, Amitava Sengupta
Journal: Blood (2021)
Diagnostic Performance of Dynamic Myocardial Perfusion Imaging Using Dual-Source Computed Tomography
Authors: Kakuya Kitagawa, Satoshi Nakamura, Hideki Ota, Ryo Ogawa, Takehito Shizuka, Tadahiro Kubo, Yan Yi, Tatsuro Ito, Naoki Nagasawa, Taku Omori, Shiro Nakamori, Tairo Kurita, Jun Sugisawa, Naoki Hatori, Hitoshi Nakashima, Yining Wang, Teruhito Kido, Kouki Watanabe, Yasuharu Matsumoto, Kaoru Dohi, Hajime Sakuma
Journal: Journal of the American College of Cardiology (2021)
Prevalence of Smoldering Multiple Myeloma: Results from the Iceland Screens, Treats, or Prevents Multiple Myeloma (iStopMM) Study
Authors: Sigrun Thorsteinsdottir, Gauti Kjartan Gislason, Thor Aspelund, Sæmundur Rögnvaldsson, Jon Thorir Thorir Oskarsson, Iris Petursdottir, Jon Kristinn Sigurdsson, Gudrun Asta Sigurdardottir, Asdis Rosa Thordardottir, Brynjar Vidarsson, Pall Torfi Onundarson, Bjarni Agnar Agnarsson, Margret Sigurdardottir, Ingunn Thorsteinsdottir, Isleifur Olafsson, Elias Eythorsson, Asbjorn Jonsson, Petros Kampanis, Malin Hultcrantz, Brian G.M. Durie, Thorvardur Jon Love, Stephen Harding, Ola Landgren, Sigurdur Yngvi Kristinsson
Journal: Blood (2021)
Results from a Phase 1 Study to Evaluate a Memory-Enriched CD19-Specific CAR T Cell Platform in Adult Patients with CD19+ B-Cell Non-Hodgkin Lymphoma (B-NHL)
Authors: Tanya Siddiqi, Xiuli Wang, M. Suzette Blanchard, Jamie Wagner, Vibhuti Vyas, Mary C. Clark, Sandra Thomas, Baishakhi Barva, Angelica Gamez, Leslie L. Popplewell, Alex F. Herrera, Elizabeth Budde, Liana Nikolaenko, Christine E Brown, Stephen J Forman
Journal: Blood (2021)
Low Exposure Extended Dosing Mimicking Clinical Exposures of the Oral Formulation of Azacitidine Results in a Sustained Hypomethylation and Targets Leukemic Stem Cells
Authors: Danny V Jeyaraju, Maryam Alapa, Ann Polonskaia, Alberto Risueño, Aarif Ahsan, Chao Wang, Prakash Subramanyam, Jammula Sriganesh, Amit Anand, Gaurav Jain, Madhusudhan Reddy, Kaushik Ghosh, Charalampos Kyriakopoulos, Nathalie Lailler, Christopher Hartl, Daniel Lopes de Menezes, Patrick Hagner, Anjan Thakurta
Journal: Blood (2021)
Abstract PO-103: Cellular origin influences immune microenvironment in a pancreatic cancer mouse model with loss of Pten and activation of Kras
Authors: Yan Dou, Wesley Hunt, Justin Chhuor, Farnaz Taghizadeh, Atefeh Samani, Karnjit Sarai, Claire Dubois, David F. Schaeffer, Maike Sander, Janel L. Kopp
Journal: Cancer Research (2021)

Abstract Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with an overall 5-year survival rate of merely 9%. Although mouse studies in the past decade have made progress towards a better understanding of how PDAC cellular origin affects tumorigenesis, there hasn’t been study on the immune microenvironment differences between precursor lesions and PDAC derived from acinar and ductal cells. Following our previous study that showed loss of Pten with oncogenic KrasG12D mutations in the ductal cells (KPtenDuct/+) resulted the formation of intraductal papillary mucinous neoplasias (IPMN) as the precursor lesion in mice, we further found siminar mutations in the acinar cells (KPtenAcinar/+) formed pancreatic intraepithelial neoplasia (PanIN) instead. We subsequently used the KPtenDuct/+ and KPtenAcinar/+ models to elucidate the effect of cellular origin on the immune microenvironment by performing immunohistochemistry. We looked at immune cell infiltration densities between precursor lesions and PDAC derived from KPtenDuct/+ and KPtenAcinar/+ models and will present the data during the conference. Additionally, macrophages polarized by conditioned media derived from KPtenDuct/+ and KPtenAcinar/+ PDAC cells showed distinctive polarization status, indicating cellular origin could result in PDAC with different cytokine and chemokine profiles that affect the immune microenvironment. Our study is the first to directly compare immune cell population between acinar- and ductal-derived PDAC originating from different types of precursor lesions with the same genetic background. Our study suggests the potential role of cellular origin on influencing PDAC immune heterogeneity. Citation Format: Yan Dou, Wesley Hunt, Justin Chhuor, Farnaz Taghizadeh, Atefeh Samani, Karnjit Sarai, Claire Dubois, David F. Schaeffer, Maike Sander, Janel L. Kopp. Cellular origin influences immune microenvironment in a pancreatic cancer mouse model with loss of Pten and activation of Kras [abstract]. In: Proceedings of the AACR Virtual Special Conference on Pancreatic Cancer; 2021 Sep 29-30. Philadelphia (PA): AACR; Cancer Res 2021;81(22 Suppl):Abstract nr PO-103.
Abstract 9560: Identifying Best Practices for Education and Training of Resuscitation Teams for In-Hospital Cardiac Arrest
Authors: Theresa Anderson, Sarah Krein, Kayla Secrest, Brad Trumpower, Timothy Guetterman, Molly Harrod, Steven Kronick, Richard J Schildhouse, James Pribble, Paul S Chan, Brahmajee K Nallamothu
Journal: Circulation (2021)

Background: In-hospital cardiac arrest (IHCA) leads to poor survival. Research suggests provider skills may play a role, but little is known on how education and training differ across hospitals. Methods: We conducted a qualitative analysis of semi-structured interview data obtained from 9 diverse hospitals from the AHA Get With The Guidelines registry, selected based on IHCA survival performance (5 top, 1 middle, 3 bottom). Thematic analysis was used to identify best practices related to training and education of resuscitation teams. Results: In total, 129 interviews were conducted with hospital staff including nurses, respiratory therapists, physicians, pharmacists, and other staff yielding 78 hours of interview time. Four themes related to training and education were identified: engagement, clear communication, consistency, and leadership listening. Top hospitals encouraged employee engagement with branding and prioritizing hands-on learning over passive didactics. Clear communication was accomplished with debriefing, structured institutional review, and continual, frequent department education. Consistency was a cornerstone to culture change and achieved with uniform policies for simulation practice as well as routine practice (weekly, monthly, quarterly). Finally, sites excelling in IHCA survival had responsive leadership who listened and adapted programs to fit staff needs. A striking characteristic was also multidisciplinary leadership participation. Conclusions: Among top hospitals, we identified core elements for successful training of resuscitation teams. Developing tools to address these areas may help improve IHCA outcomes.