tbuckley/cabot-search huggingface dataset:
Engineered Cell‐Derived Vesicles Displaying Targeting Peptide and Functionalized with Nanocarriers for Therapeutic microRNA Delivery to Triple‐Negative Breast Cancer in Mice (Adv. Healthcare Mater. 5/2022)
Authors: Rajendran JC Bose, Uday Sukumar Kumar, Fernando Garcia‐Marques, Yitian Zeng, Frezghi Habte, Jason R McCarthy, Sharon Pitteri, Tarik F Massoud, Ramasamy Paulmurugan
Journal: Advanced Healthcare Materials (2022)

Extracellular Vesicles — A Versatile Biomaterial In article number 2101387 Rajendran J. C. Bose and co-workers demonstrate an effective anticancer therapy by developing PLGA-nanocarriers loaded with antimiRNA-21 or antimiRNA-10b using engineered tumor cell derived extracellular vesicles (eEVs) that display tumor specific receptor targeting peptide to achieve therapeutic effect by reprogramming cancer cells.
Paediatric nutrition
Authors: Ajstanlv Ehforrest
Journal: Gut (1996)

Cirrhotic patients have a characteristic hyperdynamic systemic circulation and evidence of renal vasoconstriction and tubular dysfunction, maximal in patients with ascites.These renal abnormalities are reproduced by stimulation of adenosine (ADO)-1 receptors in the kidney.Aim: To assess the systemic and renal effects of a novel ADO-1 antagonist (FK352) in cirrhotic patients with ascites.Patients: Eight cirrhotic patients (4 males) were studied (mean age 52.3 years (3.3), mean CPS 8.1 (0.5)).None were taking vasoactive medications and diuretics were stopped 1 week prior to the study.Methods: Urine and plasma were collected at half hourly intervals for 2 hours before and 2 hours after administration of 10mg (first 4 patients) or 25mg FK352 (next 4 patients) to measure absolute sodium excretion (Ur.Na), free water clearance (H20 Cl.) and estimate GFR and renal plasma flow (RPF) using inulin and PAH clearance methods.Unilateral renal vein flow (RBF) (thermodilution method), cardiac index (CI) and systemic vascular resistance index (SVRI) were measured prior to and following drug administration.Results: Pre and post dru administration results are summarised:Ur. Na Ur. volume H20 Cl RBF (umol) (ml)(mVmin) mmin) Pre- 209.7(106.5)207.8(53.3)3.8(1.2) 451.7 (146.5)Post- 549.0(159.5)392.5(84.3)7.9(2.2) 589.0 (154.3)p value p<0.01 p=0.02 p=0.05 p<0.05No changes were seen in CI or SVRI.Clearance results are awaited.Conclusion: ADO appears to have a role in the renal impairment seen in cirrhosis, acting via ADO-1 receptors.ADO-1 specific antagonism offers a new therapeutic approach to the management of cirrhotic ascites and the associated renal dysfunction.
Earlier Anti-TNF Initiation Leads to Long-term Lower Health Care Utilization in Crohn’s Disease but Not in Ulcerative Colitis
Authors: Laura E Targownik, Charles N Bernstein, Eric I Benchimol, Gilaad G Kaplan, Harminder Singh, Aruni Tennakoon, Zoann Nugent, Stephanie B Coward, M Ellen Kuenzig, Sanjay K Murthy
Journal: Clinical Gastroenterology and Hepatology (2022)
Reinforcement Learning in Patients With Mood and Anxiety Disorders vs Control Individuals
Authors: Alexandra C. Pike, Oliver J. Robinson
Journal: JAMA Psychiatry (2022)

Computational psychiatry studies have investigated how reinforcement learning may be different in individuals with mood and anxiety disorders compared with control individuals, but results are inconsistent.To assess whether there are consistent differences in reinforcement-learning parameters between patients with depression or anxiety and control individuals.Web of Knowledge, PubMed, Embase, and Google Scholar searches were performed between November 15, 2019, and December 6, 2019, and repeated on December 3, 2020, and February 23, 2021, with keywords (reinforcement learning) AND (computational OR model) AND (depression OR anxiety OR mood).Studies were included if they fit reinforcement-learning models to human choice data from a cognitive task with rewards or punishments, had a case-control design including participants with mood and/or anxiety disorders and healthy control individuals, and included sufficient information about all parameters in the models.Articles were assessed for inclusion according to MOOSE guidelines. Participant-level parameters were extracted from included articles, and a conventional meta-analysis was performed using a random-effects model. Subsequently, these parameters were used to simulate choice performance for each participant on benchmarking tasks in a simulation meta-analysis. Models were fitted, parameters were extracted using bayesian model averaging, and differences between patients and control individuals were examined. Overall effect sizes across analytic strategies were inspected.The primary outcomes were estimated reinforcement-learning parameters (learning rate, inverse temperature, reward learning rate, and punishment learning rate).A total of 27 articles were included (3085 participants, 1242 of whom had depression and/or anxiety). In the conventional meta-analysis, patients showed lower inverse temperature than control individuals (standardized mean difference [SMD], -0.215; 95% CI, -0.354 to -0.077), although no parameters were common across all studies, limiting the ability to infer differences. In the simulation meta-analysis, patients showed greater punishment learning rates (SMD, 0.107; 95% CI, 0.107 to 0.108) and slightly lower reward learning rates (SMD, -0.021; 95% CI, -0.022 to -0.020) relative to control individuals. The simulation meta-analysis showed no meaningful difference in inverse temperature between patients and control individuals (SMD, 0.003; 95% CI, 0.002 to 0.004).The simulation meta-analytic approach introduced in this article for inferring meta-group differences from heterogeneous computational psychiatry studies indicated elevated punishment learning rates in patients compared with control individuals. This difference may promote and uphold negative affective bias symptoms and hence constitute a potential mechanistic treatment target for mood and anxiety disorders.
Oral bacteria, oral health, and adverse pregnancy outcomes
Authors: Biyang Xu, Yiping W. Han
Journal: Periodontology 2000 (2022)

Abstract The link between oral health and adverse pregnancy outcomes has been suggested by numerous epidemiological studies. More recent studies indicate the relationship between severity of periodontal disease and adverse pregnancy outcomes. Two virulence mechanisms are proposed: direct invasion of oral microorganisms or their components into the fetal‐placenta unit and inflammatory mediators produced in the oral cavity affecting the fetal‐placenta unit. While interventional periodontal therapy still yielded contradictory results, animal studies suggest that maternal supplementation of omega‐3 fatty acids protects the fetus by suppressing inflammation as well as bacteria proliferation in the placenta. This article reviews the recent epidemiological, mechanistic, interventional, and therapeutic studies of oral health and adverse pregnancy outcomes.
Glycemic Control with Improvement in HOMA2 IR and HOMA2 Beta: Impact of Digital Twin Enabled Precision Nutrition for Remission of Diabetes
Authors: Paramesh Shamanna, Shashank Joshi, Lisa Shah, Mala Dharmalingam, Arun Vadavi, Suresh Damodaran, Jahangir Mohammed, Maluk Mohamed, Terrence Poon, Ashok Keshavamurthy, Thajudeen Mohamed, Suchitra Bhonsley
Journal: Metabolism (2022)
Diagnosis and Treatment of ERBB2-Positive Metastatic Colorectal Cancer
Authors: John H. Strickler, Takayuki Yoshino, Rondell P. Graham, Salvatore Siena, Tanios Bekaii-Saab
Journal: JAMA Oncology (2022)

Amplification of ERBB2 (formerly referred to as HER2) is present in nearly 3% of patients with metastatic colorectal cancer overall and 5% of patients with KRAS and NRAS wild-type tumors. Despite the availability of several ERBB2-targeted therapeutic options for patients with ERBB2-positive breast and gastric/gastroesophageal tumors, to date, there are currently no approved therapies for patients with ERBB2-positive metastatic colorectal cancer, although ERBB2-targeted therapies are recommended in National Comprehensive Cancer Network guidelines. Recent evidence indicates that anti-ERBB2 therapeutic strategies are active in patients with ERBB2-positive metastatic colorectal cancer and could potentially represent a new standard-of-care.The protein ERBB2 is a member of a family of epidermal growth factor receptors that also includes epidermal growth factor receptor (ERBB1), ERBB3, and ERBB4. Amplification of ERBB2 leads to overexpression of the ERBB2 tyrosine kinase receptor, resulting in aberrant signaling and cell migration, growth, adhesion, and differentiation. Colorectal tumors that harbor ERBB2 amplification are more likely to originate on the left side of the colon, are associated with primary and acquired resistance to anti-epidermal growth factor receptor therapies, and have increased incidence of central nervous system metastases. Using immunohistochemistry, fluorescence in situ hybridization, next-generation sequencing, and liquid biopsy techniques, several randomized clinical trials have evaluated the efficacy of ERBB2-targeted therapies in patients with ERBB2-positive metastatic colorectal cancer. These therapies include monoclonal antibodies, antibody-drug conjugates, and tyrosine kinase inhibitors, many of which were associated with favorable efficacy and safety profiles when treating patients with ERBB2-positive metastatic colorectal cancer.The results of this review suggest the ERBB2 receptor is a promising target for patients with metastatic colorectal cancer; however, to date, no therapies are approved for use in this patient population. Therefore, it is imperative to continue to work to address this unmet need so that patients with ERBB2-positive metastatic colorectal cancer have therapeutic options should they become refractory to treatment with standard therapies.
Ten‐eleven translocation‐2 inactivation restrains IL‐10‐producing regulatory B cells to enable antitumor immunity in hepatocellular carcinoma
Authors: Zhou Lu, Ronghua Liu, Yining Wang, Mengxia Jiao, Zhongchen Li, Zhiqiang Wang, Cheng Huang, Guoming Shi, Aiwu Ke, Luman Wang, Ying Fu, Jie Xia, Haoyu Wen, Jian Zhou, Xiaoying Wang, Dan Ye, Jia Fan, Yiwei Chu, Jiabin Cai
Journal: Hepatology (2022)

IL-10-producing regulatory B cells (IL-10 + B cells), a dominant regulatory B cell (Breg) subset, foster tumor progression. However, the mechanisms underlying their generation in HCC are poorly understood. Ten-eleven translocation-2 (TET2), a predominant epigenetic regulatory enzyme in B cells, regulates gene expression by catalyzing demethylation of 5-methylcytosine into 5-hydroxymethyl cytosine (5hmC). In this study, we investigated the role of TET2 in IL-10 + B cell generation in HCC and its prospects for clinical application.TET2 activation in B cells triggered by oxidative stress from the HCC microenvironment promoted IL-10 expression, whereas adoptive transfer of Tet2 -deficient B cells suppressed HCC progression. The aryl hydrocarbon receptor is required for TET2 to hydroxylate Il10 . In addition, high levels of IL-10, TET2, and 5hmc in B cells indicate poor prognosis in patients with HCC. Moreover, we determined TET2 activity using 5hmc in B cells to evaluate the efficacy of anti-programmed death 1 (anti-PD-1) therapy. Notably, TET2 inhibition in B cells facilitates antitumor immunity to improve anti-PD-1 therapy for HCC.Our findings propose a TET2-dependent epigenetic intervention targeting IL-10 + B cell generation during HCC progression and identify the inhibition of TET2 activity as a promising combination therapy with immune checkpoint inhibitors for HCC.
Editorial: Hormone patterns in anorexia nervosa.
Journal: BMJ (1975)

pH of the solution the greater the fall in viscosity.18Sulphur containing amino-acids have been used by aerosol19 and by mouth20 to reduce the viscosity of mucoid sputum.They are thought to act by disrupting disulphide bonds, which are important in maintaining the gel structure of mucus.In a single-blind study in which S-carboxymethylcysteine was given to bronchitics expectoration was eased, sputum volume was increased, and there was an improvement in ventilatory tests.21Bromhexine is a synthetic derivative from a plant Abhatoda vasica, and when given to chronic bronchitics by mouth it leads to an increase in sputum volume and a re- duction in sputum viscosity,22 but it is possible to show an improvement in ventilatory capacity or the clinical condition only in mildly disabled outpatient bronchitics.2'This disappointing result is true of expectorants in general, even when the substances used are shown to be pharmacologically active.
Predicting True Time to Recovery From Insulin-induced Hypoglycemia With Dasiglucagon
Authors: Tadej Battelino, Timothy Bailey, Ramin Tehranchi, Leslie Klaff, Thomas R. Pieber, Ulrike Hövelmann, Leona Plum-Mörschel, Anita E. Melgaard, Ronnie Aronson, Linda A. DiMeglio, Thomas Danne, Anne Peters, David Kendall
Journal: Metabolism (2022)
Evolutionarily conserved bacterial effectors hijack abscisic acid signaling to induce an aqueous environment in the apoplast
Authors: Charles Roussin-Léveillée, Gaële Lajeunesse, Méliane St-Amand, Varusha Pillay Veerapen, Guilherme Silva-Martins, Kinya Nomura, Sandrine Brassard, Ayooluwa Bolaji, Sheng Yang He, Peter Moffett
Journal: Cell Host & Microbe (2022)
Rheumatoid Pachymeningitis
Authors: H J Tan, A A Raymond, P P Phadke, Z Rozman
Journal: JAMA (1963)

Symptomatic rheumatoid pachymeningitis is a rare extra-articular manifestation of rheumatoid arthritis. Clinical symptoms are non-specific and diagnosis is frequently made by exclusion. We present a 61-year-old woman with a 9-year history of rheumatoid arthritis presenting with deafness and progressive disability over a two month duration. She was diagnosed as having rheumatoid pachymeningitis based on the cerebral magnetic resonance imaging findings.
Polyvinylamine with moderate binding affinity as a highly effective vehicle for RNA delivery
Authors: Ye Tian, Yipu Zhao, Chong Yin, Shenxing Tan, Xue Wang, Chaofei Yang, Tuo-Di Zhang, Xi Zhang, Fei Ye, Jing Xu, Xianglong Wu, Li Ding, Jie Zhang, Jiawei Pei, Xue-Ting Wang, Rui Xue Zhang, Jianrong Xu, Weisi Wang, Carlos D.M. Filipe, Todd Hoare, Da-Chuan Yin, Airong Qian, Xudong Deng
Journal: Journal of Controlled Release (2022)
<i>Hand-Atlas der Sensiblen und Motorischen Gebiete der Hirn- und Rückenmarksnerven.</i>(Hand-Atlas of the Areas of the Cranial and Spinal Nerves.) Von Prof. Dr. C. Hasse. Wiesbaden: J. F. Bergmann. 1895
Authors: J. M. M.
Journal: American Journal of Psychiatry (1896)
Letter: Coeliac disease and diffuse pulmonary disease.
Authors: Derek Carson, E Carson
Journal: BMJ (1976)

investigated 30 fatal cases in which we are convinced that dextropropoxyphene played the major part in the death.All these patients had taken Distalgesic tablets, some with suicidal intent and many in association with alcohol.The combined cerebral depressant effect of dextropropoxyphene and alcohol seems particularly hazardous, although all the victims had apparently ingested the analgesic in doses exceeding the therapeutic range.It appears to us from the absence of published material in Britain that the problem has not yet been fully recognised, although recent information, not at variance with our own experience, is now reaching us from the USA.2We are at present in the process of collating our detailed results for publication, but feel that the time is opportune to highlight what we feel is an increasingly serious problem.
Polymorphism of apolipoprotein E in children with metabolic diseases of the biliary tract
Authors: Belousova OYu, O.V. Shutova, N.V. Pavlenko, I.G. Solodovnichenko, O.M. Вabadzhanian, L.G. Voloshyna, O.B. Hanzii, Abbas Kaafarani, K.V. Savytska, L.V. Kazaryan
Journal: Metabolism (2022)
Correction: Risk factors and long-term course of gastroesophageal reflux disease after peroral endoscopic myotomy: A large-scale multicenter cohort study in Japan
Authors: Hironari Shiwaku, Hiroki Sato, Yuto Shimamura, Hirofumi Abe, Junya Shiota, Chiaki Sato, Masaki Ominami, Hiroyuki Sakae, Yoshitaka Hata, Hisashi Fukuda, Ryo Ogawa, Jun Nakamura, Tetsuya Tatsuta, Yuichiro Ikebuchi, Hiroshi Yokomichi, Suguru Hasegawa, Haruhiro Inoue
Journal: Endoscopy (2022)

Correction to: Risk factors and long-term course of gastroesophageal reflux disease after peroral endoscopic myotomy: A large-scale multicenter cohort study in JapanEndoscopy eFirstDOI: 10.1055/a-1753-9801
Dual-Time-Point 18F-Fluorocholine PET/CT Improves Characterization of Thyroid Nodules in Patients Referred for Primary Hyperparathyroidism: A Proof of Concept Study: Reply
Authors: Alessio Imperiale, Jacob Bani, David Taïeb
Journal: Clinical Nuclear Medicine (2022)

Nuclear Medicine and Molecular Imaging, Institut de Cancérologie de Strasbourg Europe (ICANS), Strasbourg University, Strasbourg, France; Molecular Imaging—DRHIM, IPHC, UMR 7178, CNRS/Unistra, Strasbourg, France [email protected] Nuclear Medicine and Molecular Imaging, Institut de Cancérologie de Strasbourg Europe (ICANS), Strasbourg University, Strasbourg, France Nuclear Medicine, La Timone University Hospital, Aix-Marseille University, Marseille, France; European Center for Research in Medical Imaging, Aix-Marseille University, Marseille, France
Prenatal screening for hepatitis B antigen
Authors: J. W. Ross
Journal: JAMA (1989)

<h3>In Reply.—</h3> Dr Ross questions two issues discussed in the ACIP<sup>1</sup>recommendations for routine HBsAg screening of pregnant women: the scientific justification that treatment for infants born to hepatitis B virus carrier mothers be initiated within 24 hours of birth and the feasibility of obtaining HBsAg test results within 24 hours for women who come to the hospital to deliver without prior HBsAg screening. The scientific basis of the need for rapid treatment of exposed infants stems from early studies of the efficacy of hepatitis B immune globulin (HBIG) in the prevention of perinatal hepatitis B virus transmission. One study showed that a single dose of HBIG had a 50% efficacy if given within the first 48 hours of life but had no efficacy if given later.<sup>2</sup>On the basis of this information, in all subsequent studies of HBIG and hepatitis vaccine researchers administered the HBIG as soon
Editorial: Breast-feeding: the immunological argument.
Journal: BMJ (1976)

In stage 1 disease, however, the prognosis is so good that it may be questioned whether it is right to submit the children to intensive treatment.Neither radiotherapy nor chemotherapy is without risks, and some children may die as a direct result of treatment.In the review by Bond13 no child under the age of 1 year with stage 1 disease was given radiotherapy to the renal bed, and none of these children relapsed.The National Wilms's Tumour Study Group is also examining the impor- tance of radiotherapy in stage 1 disease,14 but it will be some time before there is a clear indication of what should be done.Another approach is to discover those groups particularly at risk: for example, the St Jude Children's Research Hospital15 has found that pulmonary metastases are more frequent when any renal vessels contain tumour.This may indicate that a further refinement in staging may be necessary.
Hydrazine poisoning.
Authors: F. J. Reid
Journal: BMJ (1965)

When the diathermy is applied to the thorax or neck of an insulated patient the shortest electrical path is through the anaes- thetic tubing and machine or the anaesthetist, who usually has bare hands and conducting boots.When patients are intubated, the endotracheal tube is non-conducting when dry, and electrical contact is first made with the metal connector, which can easily make contact with the skin of the face but is often
Racist Factors Underlying Prostate Cancer Disparities
Authors: Michael Poulson
Journal: JAMA Oncology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
The Gulstonian Lectures on Anaemia
Authors: S. Coupland
Journal: BMJ (1881)

THE BRITJSH MEDICAL 7OURNAL.589 J89~~~~~~~~ cases, excluding, of course, those secondary to valvular lesions, endo- arteritis, and emphysema, the heart is only implicated to the amount of- 3.3 per cent. of the eases,The secondaryforms may be very obvious or very insidious acute or chronic, at one time more-interstitial, at another more parenchymA.. tous; often mixed with amyloid degeneration; but, as a rule, the renal mischief only plays second fiddle, and is an adjunct-to other serious diseases.Still, at times and in some cases, the renal clinical symptoms, although secondary, assume a great importance, and engage more attention than the general condition out of which, they arise.Bamberger's primary form of Bright's disease comprised both glandu- lar or Parenchymatous-and interstitial nephritis-807 cases -in all.Of these, he observed -67 cases which were acute .in-theircommencement and course, 357 which were entirely chronic, and 383 which lived on to renal atrophy.As regards age, he proffers a most reliable table.Excluding the scarlatinal form, which, early as well as latest-authorities acknowledge, is not morbus Brightii in Bright's sense, the facts stand hus. Decennium.Cases.
The Medical News Visiting List for 1889.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal