tbuckley/cabot-search huggingface dataset:
Multisensory coding of angular head velocity in the retrosplenial cortex
Authors: Sepiedeh Keshavarzi, Edward F. Bracey, Richard A. Faville, Dario Campagner, Adam L. Tyson, Stephen C. Lenzi, Tiago Branco, Troy W. Margrie
Journal: Neuron (2021)

To successfully navigate the environment, animals depend on their ability to continuously track their heading direction and speed. Neurons that encode angular head velocity (AHV) are fundamental to this process, yet the contribution of various motion signals to AHV coding in the cortex remains elusive. By performing chronic single-unit recordings in the retrosplenial cortex (RSP) of the mouse and tracking the activity of individual AHV cells between freely moving and head-restrained conditions, we find that vestibular inputs dominate AHV signaling. Moreover, the addition of visual inputs onto these neurons increases the gain and signal-to-noise ratio of their tuning during active exploration. Psychophysical experiments and neural decoding further reveal that vestibular-visual integration increases the perceptual accuracy of angular self-motion and the fidelity of its representation by RSP ensembles. We conclude that while cortical AHV coding requires vestibular input, where possible, it also uses vision to optimize heading estimation during navigation.
A Multi-Center Retrospective Review of COVID-19 Outcomes in Patients with Lymphoid Malignancy
Authors: Yun Choi, Jessica Caro, Xiaochun Li, Arshed Al-Obeidi, Sharyn Lynn Kurtz, Austin I. Kim, Julie E. Chang, Adam J. Olszewski, Adam Zayac, Andrew Matthews, Stefan K. Barta, Suchitra Sundaram, Francisco J. Hernandez-Ilizaliturri, Lori A. Leslie, Paolo Caimi, Jordan Carter, Kevin A. David, Andrew M. Evens, Myung Sun Kim, Sarah J. Nagle, Judith Goldberg, Catherine S. Diefenbach
Journal: Blood (2021)
Hsa‐miR‐335 enhances cell migration and invasion in lung adenocarcinoma through targeting Copine‐1
Authors: Yang Wang, Jing Zhang, Li‐Ye Zhong, Shang‐Jia Huang, Nan‐Nan Yu, Lan Ouyang, Yu‐Long Niu, Jun‐Xiong Chen, Chun‐Hua Lu, Qing‐Yu He
Journal: MedComm (2021)

Abstract Lung adenocarcinoma (LAC) is one of the most common pulmonary adenocarcinomas with a high peak of mortality, and metastasis is the main culprit of LAC deaths. microRNAs play important role in cancer metastasis, and thus are regarded as potential diagnostic and prognostic markers for human cancers. However, many miRNAs exhibit dual roles in diverse cellular contexts. Here, we revealed that hsa‐miR‐335, a previously reported tumor suppressor, exhibited an oncogenic role in LAC. Overexpression of miR‐335 enhanced the abilities of A549 and H1299 cells to invade and migrate by regulating epithelial‐mesenchymal transition, while inhibition of miR‐335 exhibited an opposite effect in vitro and in vivo. Mechanically, miR‐335 inhibited the expression of Copine‐1 (CPNE1), an NF‐κB suppressor, through interacting with its mRNA 3′UTR, while mutating the binding sites abolished this inhibitory effect. This finding not only highlights the suppressive effect of CPNE1 on cell motility, but also provides new insight into miR‐335 in promoting LAC metastasis.
Real-World Disease Burden, Costs and Resource Utilization of Hospital-Based Care Among Mantle Cell Lymphoma, Waldenström Macroglobulinemia, Marginal Zone Lymphoma and Chronic Lymphocytic Leukemia: Disparities and Risk Factors
Authors: Asher Chanan-Khan, Keri Yang, Sizhu Liu, Zhun Cao, Dorothy Baumer, Shanthi Krishnaswami, Boxiong Tang, Sikander Ailawadhi
Journal: Blood (2021)
Analysis of Outcomes and Predictors of Response in Patients with Relapsed Mantle Cell Lymphoma Treated with Brexucabtagene Autoleucel
Authors: Jason T. Romancik, Subir Goyal, James N Gerson, Hatcher J Ballard, Yazeed Sawalha, David A. Bond, Michael Joseph Rogalski, Irl Brian Greenwell, Koen van Besien, Samuel Yamshon, Reem Karmali, Imran Nizamuddin, Pallawi Torka, Victor A. Chow, Mazyar Shadman, Nilanjan Ghosh, Tamara K. Moyo, Timothy S. Fenske, Alexandra Rezazadeh, Natalie S Grover, Kami J. Maddocks, Caron Jacobson, Jonathon B. Cohen
Journal: Blood (2021)
Tumor Associated Macrophages Promoted Fatal Patient Derived Acute Promyelocytic Leukemia <i>In Vivo</i>
Authors: Isabel Weinhäuser, Diego A Pereira-Martins, Jacobien R Hilberink, Luciana Yamamoto Almeida, Douglas RA Silveira, Lynn Quek, Shanna M Hogeling, Jose Mauricio Mota, Emanuele Ammatuna, Antonio R. Lucena-Araujo, Gerwin A. Huls, Jan Jacob Schuringa, Eduardo M Rego
Journal: Blood (2021)
Sodium alginate and naloxone loaded macrophage-derived nanovesicles for the treatment of spinal cord injury
Authors: Xiaoyao Liu, Xue Jiang, Qi Yu, Wenwen Shen, He Tian, Xifan Mei, Chao Wu
Journal: Asian Journal of Pharmaceutical Sciences (2021)

Spinal cord injury (SCI) causes Ca2+ overload, which can lead to inflammation and neuronal apoptosis. In this study, we prepared a nanovesicle derived from macrophage membrane (MVs), which encapsulated sodium alginate (SA) and naloxone (NAL) to inhibit inflammation and protect neurons by reducing the free Ca2+concentration at the SCI site. Based on the transmission electron microscopy (TEM) image, the encapsulated sample (NAL-SA-MVs) had a particle size of approximately 134 ± 11 nm and exhibited a sustained release effect. The encapsulation rate of NAL and SA was 82.07% ± 3.27% and 72.13% ± 2.61% in NAL-SA-MVs, respectively. Targeting tests showed that the NAL-SA-MVs could accumulate in large quantities and enhance the concentration of SA and NAL at the lesion sites. In vivo and in vitro studies indicated that the NAL-SA-MVs could decrease the concentration of free Ca2+, which should further alleviate the inflammatory response and neuronal apoptosis. Anti-inflammation results demonstrated that the NAL-SA-MVs could reduce the pro-inflammation factors (iNOS, TNF-α, IL-1β, IL-6) and increase the expression of anti-inflammation factors (IL-10) at the cell and animal level. Concurrently, fluorescence, flow cytometry and western blot characterization showed that the apoptotic condition of the neurons was significantly inhibited. In addition, the motor function of C57 mice were significantly improved after NAL-SA-MVs treatment. In conclusion, it is suggested that the NAL-SA-MVs has tremendous potential in the treatment of SCI.
A Novel CD34-Specific T-Cell Engager Efficiently Depletes Stem Cells and Acute Myeloid Leukemia Cells <i>in Vitro</i> and <i>In Vivo</i>
Authors: Lucas C M Arruda, Liqing Jin, Melanie Lambert, Laura Sanchez Rivera, Renato Alvez, Tales Rocha de Moura, Carsten Mim, Rebecca Axelsson-Robertson, John E. Dick, Jonas Mattsson, Bjorn Onfelt, Mattias Carlsten, Michael Uhlin
Journal: Blood (2021)
Different evolutionary pathways of HIV-1 between fetus and mother perinatal transmission pairs indicate unique immune selection in fetuses
Authors: Manukumar Honnayakanahalli Marichannegowda, Michael Mengual, Amit Kumar, Elena E. Giorgi, Joshua J. Tu, David R. Martinez, Ethan O. Romero-Severson, Xiaojun Li, Liping Feng, Sallie R. Permar, Feng Gao
Journal: Cell Reports Medicine (2021)

Study of evolution and selection pressure on HIV-1 in fetuses will lead to a better understanding of the role of immune responses in shaping virus evolution and vertical transmission. Detailed genetic analyses of HIV-1 env gene from 12 in utero transmission pairs show that most infections (67%) occur within 2 months of childbirth. In addition, the env sequences from long-term-infected fetuses are highly divergent and form separate phylogenetic lineages from their cognate maternal viruses. Host-selection sites unique to neonate viruses are identified in regions frequently targeted by neutralizing antibodies and T cell immune responses. Identification of unique selection sites in the env gene of fetal viruses indicates that the immune system in fetuses is capable of exerting selection pressure on viral evolution. Studying selection and evolution of HIV-1 or other viruses in fetuses can be an alternative approach to investigate adaptive immunity in fetuses.
The Transcriptional and Epigenetic Reprogramming of Aged Hematopoietic Stem Cells Drives Myeloid Rewiring in Clonal Hematopoiesis-Associated Cytopenias
Authors: Irene Ganan-Gomez, Kelly S. Chien, Feiyang Ma, Hui Yang, Lin Tan, Philip Lorenzi, Guillermo Garcia-Manero, Simona Colla
Journal: Blood (2021)
Frequency of Vaso-Occlusive Crises Is Associated with Health-Related Quality of Life in Pediatric Patients with Sickle Cell Disease: US Cross-Sectional Surveys of Adolescents and Caregivers
Authors: Andrew D. Campbell, Avery A. Rizio, Kristen L. McCausland, Serban Iorga, Glorian P. Yen, Jincy Paulose, Soyon Lee
Journal: Blood (2021)
Decrease in community antibiotic consumption during the COVID-19 pandemic, EU/EEA, 2020
Authors: Liselotte Diaz Högberg, Vera Vlahović-Palčevski, Cátia Pereira, Klaus Weist, Dominique L Monnet
Journal: Eurosurveillance (2021)

We present a European Union/European Economic Area-wide overview of the changes in consumption of antibacterials for systemic use (ATC J01) in the community between 2019 and 2020 as reported to the European Surveillance of Antimicrobial Consumption Network. Overall antibiotic consumption decreased by 18.3% between 2019 and 2020, the largest annual decrease in the network's two-decade history. We observed a strong association between the level of community antibiotic consumption in 2019 and the size of the decrease between 2019 and 2020.
Outcomes of Nonalcoholic Steatohepatitis After Liver Transplantation: An Updated Meta-Analysis and Systematic Review
Authors: Jie Ning Yong, Wen Hui Lim, Cheng Han Ng, Darren Jun Hao Tan, Jieling Xiao, Phoebe Wen Lin Tay, Snow Yunni Lin, Nicholas Syn, Nicholas Chew, Benjamin Nah, Yock Young Dan, Daniel Q. Huang, Eunice Xiang Xuan Tan, Arun J. Sanyal, Mazen Noureddin, Mohammad Shadab Siddiqui, Mark D. Muthiah
Journal: Clinical Gastroenterology and Hepatology (2021)
Inhibition of Sars-Cov-2 Viral Replication and <i>In Vivo</i> Thrombus Formation By a Novel Plant Flavonoid
Authors: Moua Yang, Lin Lin, Christina Scartelli, Da-Yuan Chen, Anika Patel, Roelof Bekendam, Lijun Sun, Mohsan Saeed, Robert Flaumenhaft
Journal: Blood (2021)
Rare Variant Genetic Association Study for Transplant-Associated Thrombotic Microangiopathy (TA-TMA) Via Whole Exome Sequencing
Authors: Zhihui Zhang, Qian Vicky Wu, Christopher I Amos, Yanhong Liu, Hong Wei, Chao Cheng, Spiridon Tsavachidis, Angela Bryce, Sarah E Sartain, Caridad A. Martinez, Vahid Afshar-Kharghan, Jing-fei Dong, Pavan Bhatraju, Paul J Martin, Stephanie J. Lee, Robert S. Makar, Pavan K. Bendapudi, Ang Li
Journal: Blood (2021)
Abstract 9483: Detection of Lipids by Near-infrared Spectroscopy in Calcified Coronary Plaques Containing Nodular Calcification: Insights from Multimodality Imaging and Histopathologic Assessment
Authors: Kota Murai, Fumiyuki Otsuka, Yu Kataoka, Satoshi Kitahara, Takamasa Iwai, Kenichiro Sawada, Hideo Matama, Satoshi Honda, Masashi FUJINO, Shuichi Yoneda, Kensuke Takagi, Yasuhide Asaumi, Kenichi Tsujita, Teruo Noguchi
Journal: Circulation (2021)

Introduction: Detection of lipids in coronary plaques by near-infrared spectroscopy (NIRS) is based on the absorbance of NIR light and can predict future coronary events. It remains unclear whether the ability of NIRS can be applied to calcified lesions containing nodular calcification (Ca), which potentially scatters NIR light. Hypothesis: We hypothesized that detection of lipids by NIRS is overestimated in calcified coronary plaques containing nodular Ca compared with those with conventional sheet Ca. Methods: We investigated a total of 322 culprit lesions from 283 patients with CAD who underwent both NIRS-IVUS and OCT. After identifying nodular and sheet Ca on cross-sectional images in both IVUS and OCT, the presence of NIRS signals behind Ca was determined and quantified as lipid arc divided by Ca arc. In addition, consecutive 30 autopsy cases with CAD were pathologically assessed for the prevalence of lipids within nodular and sheet Ca. Results: Among 8850 cross-sections in vivo, 382 nodular and 1190 sheet Ca were identified. Generalized estimating equation modeling showed the presence of NIRS signals was more frequent in nodular Ca (79% vs. 64%, p=0.001) and the extent of NIRS signals was greater in nodular than sheet Ca (70% vs. 23%, p&lt;0.001, Figure). Multivariate analysis identified nodular Ca as an independent determinant of positive NIRS signals (Table). Among 2467 histologic coronary sections evaluated, 55 nodular and 456 sheet Ca were identified. In contrast to imaging assessment, pathology showed that the prevalence of lipids within nodular Ca was extremely low; only 4%, and less than that in sheet Ca (20%, p=0.015). Conclusions: Majority of nodular Ca exhibited positive NIRS signals, whereas lipids within nodular Ca was extremely rare in pathologic assessment. The discrepancy suggests that NIR light-based detection of lipids is overestimated in nodular Ca, which needs to be considered when interpreting co-localized lipids in calcified coronary plaques.
Real-World Outcomes of Aggressive B-Cell Non-Hodgkin Lymphoma in People Living with HIV (PLWH) Treated in Australia: An Australasian Lymphoma Alliance Study
Authors: Kenneth JC Lim, Pietro Di Ciaccio, Nada Hamad, Mark N. Polizzotto, Sam Milliken, Tara Cochrane, Zhong Goh, Briony Shaw, Evelyn Perry, Michael Gilbertson, William Kermode, Chan Yoon Cheah, Maya Latimer, Matthew Ku
Journal: Blood (2021)
Angiosarcoma of the Heart: Case Report
Authors: Marc Vanderheyden, Sofie Dhaeyer, Chirik Wah Lau, Vanessa Meert, Jan Leeman, Martin Penicka
Journal: Clinical Cardiology and Cardiovascular Interventions (2020)

Cardiac angiosarcomas are rare malignant tumors, predominantly affecting the right heart with poor survival outcomes. The current mainstay of treatment consists of surgery with or without chemotherapy, but often yields limited results with local relapse or metastatic recurrence. This case report describes 2 patients with primary angiosarcoma located in the right atrium. One patient received neo-adjuvant and adjuvant chemotherapy; both were scheduled for surgical resection. The course of disease is described followed by a comprehensive review of the literature.
Sequential and efficient neural-population coding of complex task information
Authors: Sue Ann Koay, Adam S. Charles, Stephan Y. Thiberge, Carlos D. Brody, David W. Tank
Journal: Neuron (2021)

Recent work has highlighted that many types of variables are represented in each neocortical area. How can these many neural representations be organized together without interference and coherently maintained/updated through time? We recorded from excitatory neural populations in posterior cortices as mice performed a complex, dynamic task involving multiple interrelated variables. The neural encoding implied that highly correlated task variables were represented by less-correlated neural population modes, while pairs of neurons exhibited a spectrum of signal correlations. This finding relates to principles of efficient coding, but notably utilizes neural population modes as the encoding unit and suggests partial whitening of task-specific information where different variables are represented with different signal-to-noise levels. Remarkably, this encoding function was multiplexed with sequential neural dynamics yet reliably followed changes in task-variable correlations throughout the trial. We suggest that neural circuits can implement time-dependent encodings in a simple way using random sequential dynamics as a temporal scaffold.
Combination of a Luspatercept-like Drug (RAP-GRL) and <i>Tmprss6</i>-ASO Is Superior to Either Drug Alone for Correcting β-Thalassemia
Authors: Amaliris Guerra, Perry Demsko, Paige McVeigh, Sayantani Sinha, Carlo Castruccio Castracani, Laura Breda, Carla Casu, Shuling Guo, Stefano Rivella
Journal: Blood (2021)
A Retrospective Cohort Study of Treatment Outcomes of Adult Patients with Relapsed or Refractory Low-Grade Follicular Lymphoma (ReCORD-FL)
Authors: Gilles Salles, Stephen J. Schuster, Luca Fischer, John Kuruvilla, Piers EM Patten, Bastian von Tresckow, Sonali M. Smith, Ana Isabel Jiminez Ubieto, Keith L. Davis, Saurabh P Nagar, Jie Zhang, Vamsi Bollu, Etienne Jousseaume, Roberto Ramos, Yucai Wang, Brian K. Link
Journal: Blood (2021)
Abstract 9057: Anti-inflammatory Effect of Biologic Therapy in Patients With Psoriatic Disease: A Prospective Cohort Fdg-pet Study
Authors: Kevin E Boczar, Steven Glassman, Jerry Wang, wanzhen zeng, Robert deKemp, Natalie Ward, Rob S Beanlands, Christophe A Fehlmann, George Wells, Jacob Karsh, Girish Dwivedi
Journal: Circulation (2021)

Introduction: Psoriatic arthritis (PsA) and cutaneous psoriasis (PsO) are linked with an increased risk of adverse cardiovascular events. Hypothesis: Central vascular inflammation (VI) as measured on F-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) in the ascending aorta will improve in patients following therapy with biologic agents compared to PsO patients receiving non-biologic therapy and controls. We also postulate that in patients responding to biologics, there will be an improvement in coronary microvascular dysfunction as measured by myocardial blood flow reserve (MFR) determined by rubidium-82 (82Rb) PET. Methods: We studied 3 patient cohorts (patients with PsA and/or PsO started on biologic agents, patients with PsO managed on non-biologic therapy, and patients with non-inflammatory arthritis). The primary outcome of our study was the change in VI, estimated as the target-to-background ratio by FDG PET in the most diseased segment of the ascending aorta at baseline compared to 6-month follow-up (TBRmax). We also performed 82Rb PET studies at baseline and 6-month follow-up to determine any changes on left ventricular MFR. Results: 34 participants were enrolled in the study (11 PsA and/or PsO patients on biologic agents, 13 patients in PsO group managed on non-biologic therapy, and 10 in the non-inflammatory control group). A significant drop in the thoracic aorta uptake was observed in the biologic-treated group (change in TBRmax: -0.46±0.55) when compared to the the PsO group treated with non-biologic therapy (change in TBRmax: 0.23±0.67). The group with imaging evidence of a response to biologic agents (i.e. TBRmax drop greater than median value) maintained MFR (change in MFR of 0.05±0.19) when compared to the group with a response on TBRmax that was below the median, which had a drop in MFR (-2.9±0.8) (P=0.03). Conclusions: VI in the thoracic aorta decreased compared to psoriasis patients treated with non-systemic therapies and controls. Psoriasis patients treated with biologics who demonstrated a significant response on FDG PET imaging, maintained their MFR compared to non-responders. There is a positive impact of immune therapies on VI and microvascular disease in patients with chronic inflammation.
Plea for a Simpler Life, and Fads of an Old Physician
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ADG153, an Anti-CD47 Monoclonal Antibody Prodrug, Has Strong In Vivo Anti-Tumor Activity, Minimal RBC-Related and Antigen Sink Liabilities, and Extended Half Life in Comparison with Benchmark Clinical Antibodies of the Same IgG Subclass
Authors: Bin Cai, Aaron N Nguyen, Songmao Zheng, Jianfeng Shi, Guizhong Liu, Yan Li, Felix Du, Peter Luo, Jiangchun Xu
Journal: Blood (2021)
Patient-Tailored Measurable Residual Disease Monitoring in Peripheral Blood Using Deep Sequencing and Droplet Digital PCR for Early Detection of Relapse in Childhood Acute Myeloid Leukemia: A NOPHO-DBH Collaborative Study
Authors: Anne-Sofie Skou, Kristian Løvvik Juul-Dam, Erik Delsing Malmberg, Anna Rehammar, Anastasia Soboli, Azadeh Anbarlou, Erik Kristiansson, Jonas Abrahamsson, Bernward Zeller, Kirsi Jahnukainen, Edwin Sonneveld, Birgitte Lausen, Anni Aggerholm, Hans Beier Ommen, Henrik Hasle, Linda Fogelstrand
Journal: Blood (2021)
Comparison of Prognostic Impact between the European Leukemia Net (ELN) 2017 Risk Classification and Pre-Transplant <i>WT1</i> expression in Patients Receiving Allogeneic Transplantation for Acute Myeloid Leukemia (AML)
Authors: Tong-Yoon Kim, Byung Sik Cho, Gi June Min, Sung-Soo Park, Silvia Park, Jae-Ho Yoon, Sung-Eun Lee, Ki-Seong Eom, Yoo-Jin Kim, Seok Lee, Chang-Ki Min, Seok-Goo Cho, Dong-Wook Kim, Jong-Wook Lee, Hee-Je Kim
Journal: Blood (2021)
Cryopreserved CAR-like NK Cells Pre-Complexed with the CD30/CD16A Bispecific Innate Cell Engager (ICE®) AFM13 for the Treatment of CD30 + Malignancies
Authors: Uwe Reusch, Kristina Ellwanger, Ivica Fucek, Thomas Müller, Ute Schniegler-Mattox, Jens Pahl, Michael Tesar, Joachim Koch
Journal: Blood (2021)