In patients with AF and a bioprosthetic mitral valve, rivaroxaban was noninferior to warfarin for time to clinical events
Authors: Ying X. Gue, Gregory Y.H. Lip
Journal: Annals of Internal Medicine (2021)

ACP Journal ClubApril 2021In patients with AF and a bioprosthetic mitral valve, rivaroxaban was noninferior to warfarin for time to clinical eventsYing X. Gue, PhD, Gregory Y.H. Lip, MDYing X. Gue, PhDLiverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, UK (Y.X.G., G.Y.L.)Search for more papers by this author, Gregory Y.H. Lip, MDLiverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, UK (Y.X.G., G.Y.L.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJ202104200-043 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationGuimarães HP, Lopes RD, de Barros E Silva PG, et al. Rivaroxaban in patients with atrial fibrillation and a bioprosthetic mitral valve. N Engl J Med. 2020;383:2117-26. https://pubmed.ncbi.nlm.nih.gov/33196155Clinical Impact RatingsGIM/FP/GP: Cardiology: References1 Kloecker DE, Davies MJ, Khunti K, et al. Uses and limitations of the restricted mean survival time: illustrative examples from cardiovascular outcomes and mortality trials in type 2 diabetes. Ann Intern Med. 2020;172:541-52. [PMID: 32203984] Google Scholar2 Ricci S. What does ‘non-inferior to’ really mean? A clinician thinking out loud. Cerebrovasc Dis. 2010;29:607-8. [PMID: 20413972] Google Scholar3 Lip GY, Collet JP, de Caterina R, et al. Antithrombotic therapy in atrial fibrillation associated with valvular heart disease: a joint consensus document from the European Heart Rhythm Association (EHRA) and European Society of Cardiology Working Group on Thrombosis, endorsed by the ESC Working Group on Valvular Heart Disease, Cardiac Arrhythmia Society of Southern Africa (CASSA), Heart Rhythm Society (HRS), Asia Pacific Heart Rhythm Society (APHRS), South African Heart (SA Heart) Association and Sociedad Latinoamericana de Estimulación Cardíaca y Electrofisiología (SOLEACE). Europace. 2017;19:1757-8. [PMID: 29096024] Google Scholar Author, Article, and Disclosure InformationAffiliations: Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, UK (Y.X.G., G.Y.L.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M20-7315.This article was published at Annals.org on 6 April 2021. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDirect oral anticoagulants in patients with a left-sided bioprosthetic heart valve: a systematic review and meta-analysis April 2021Volume 174, Issue 4Page: JC43KeywordsAnticoagulantsAtrial fibrillationHemorrhageInternational normalized ratioMortalityMyocardial infarctionRiversSurgerySurvival analysisTransient ischemic attacks ePublished: 6 April 2021 Issue Published: April 2021 Copyright & PermissionsCopyright © 2021 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...