tbuckley/cabot-search huggingface dataset:
Effects of State Opioid Prescribing Laws on Use of Opioid and Other Pain Treatments Among Commercially Insured U.S. Adults
Authors: Emma E. McGinty, Mark C. Bicket, Nicholas J. Seewald, Elizabeth A. Stuart, G. Caleb Alexander, Colleen L. Barry, Alexander D. McCourt, Lainie Rutkow
Journal: Annals of Internal Medicine (2022)

Background: There is concern that state laws to curb opioid prescribing may adversely affect patients with chronic noncancer pain, but the laws' effects are unclear because of challenges in disentangling multiple laws implemented around the same time. Objective: To study the association between state opioid prescribing cap laws, pill mill laws, and mandatory prescription drug monitoring program query or enrollment laws and trends in opioid and guideline-concordant nonopioid pain treatment among commercially insured adults, including a subgroup with chronic noncancer pain conditions. Design: Thirteen treatment states that implemented a single law of interest in a 4-year period and unique groups of control states for each treatment state were identified. Augmented synthetic control analyses were used to estimate the association between each state law and outcomes. Setting: United States, 2008 to 2019. Patients: 7 694 514 commercially insured adults aged 18 years or older, including 1 976 355 diagnosed with arthritis, low back pain, headache, fibromyalgia, and/or neuropathic pain. Measurements: Proportion of patients receiving any opioid prescription or guideline-concordant nonopioid pain treatment per month, and mean days' supply and morphine milligram equivalents (MME) of prescribed opioids per day, per patient, per month. Results: Laws were associated with small-in-magnitude and non–statistically significant changes in outcomes, although CIs around some estimates were wide. For adults overall and those with chronic noncancer pain, the 13 state laws were each associated with a change of less than 1 percentage point in the proportion of patients receiving any opioid prescription and a change of less than 2 percentage points in the proportion receiving any guideline-concordant nonopioid treatment, per month. The laws were associated with a change of less than 1 in days' supply of opioid prescriptions and a change of less than 4 in average monthly MME per day per patient prescribed opioids. Limitations: Results may not be generalizable to non–commercially insured populations and were imprecise for some estimates. Use of claims data precluded assessment of the clinical appropriateness of pain treatments. Conclusion: This study did not identify changes in opioid prescribing or nonopioid pain treatment attributable to state laws. Primary Funding Source: National Institute on Drug Abuse.
IgG4-related sclerosing cholangitis involving the gallbladder mimicking a hilar cholangiocarcinoma
Authors: Yun Chae Lee, Hyung Ku Chon, Keum Ha Choi
Journal: Endoscopy (2022)

A 76-year-old man presented with abdominal pain, jaundice, and fever. Abdominal computed tomography demonstrated wall thickening of the gallbladder with gallstones surrounding a large low-density lesion communicating with the gallbladder and a thickened, enhancing wall at the hepatic hilum and common hepatic duct (CHD). Magnetic resonance cholangiopancreatography (MRCP) showed a stricture at the hilum extending to the CHD, suggestive of a hilar cholangiocarcinoma ([Fig. 1]). Percutaneous catheter drainage for liver abscess and endoscopic retrograde cholangiopancreatography with stent placement for biliary drainage and biopsy was performed. Histology did not show malignancy. Same-session endoscopic ultrasound (EUS)-guided tissue acquisition and peroral cholangioscopy (POCS) were performed. EUS revealed symmetrical and smooth wall thickening of the hilum and CHD. EUS-guided tissue acquisition was performed using a 22-gauge needle ([Fig. 2]). POCS (SpyGlass DS; Boston Scientific, Natick, Massachusetts, USA) demonstrated a stricture with dilated vessels and hyperemic and papillary-appearing mucosa in the hilum and CHD ([Video 1]). Specimens were obtained using the SpyBite biopsy forceps (Boston Scientific). The pathology results from EUS-guided tissue acquisition and SpyBite forceps biopsy showed stromal fibrosis with lymphoplasmacytic infiltration and more than 10 IgG4-positive plasma cells per high-power field (HPF) ([Fig. 3]). Serum IgG4 level was 185 mg/dL. Laparoscopic cholecystectomy was performed, and on histology the wall of the gallbladder showed multifocal lymphoplasmacytic infiltrations with more than 10 IgG4-positive plasma cells per HPF. The patient received steroid treatment at a dosage of 40 mg/day. After 4 weeks of steroid treatment, MRCP demonstrated improved luminal narrowing of the hilum and CHD ([Fig. 4]). Therefore, IgG4-related sclerosing cholangitis involving the gallbladder was diagnosed. The patient was placed on long-term low-dose steroid treatment, the biliary stent was removed, and the patient has now had no recurrence of the cholangitis for over 1 year.
Factors predicting axial spondyloarthritis among first-degree relatives of probands with ankylosing spondylitis: a family study spanning 35 years
Authors: Sjef M van der Linden, Muhammad Asim Khan, Zhixiu Li, Heinz Baumberger, Hermine van Zandwijk, Kazim Khan, Peter M Villiger, Matthew A Brown
Journal: Annals of the Rheumatic Diseases (2022)

Factors predicting axial spondyloarthritis (axSpA) among first-degree relatives (FDRs) of ankylosing spondylitis (AS) patients need to be defined. We investigated the predictive value of the probands' HLA-B27 and radiographic sacroiliitis status on disease occurrence among their FDR. We also assessed the predictive value of features of the clinical history, including chronic inflammatory back pain (CIBP) and acute anterior uveitis (AAU), among the FDR and how they can be used to improve classification and diagnosis of axSpA.In 1985, we studied 363 AS probands and 806 FDR who underwent rheumatologic examination, completed questionnaires, provided blood samples for HLA-typing and underwent radiography of sacroiliac joints. At follow-up in 2018-2019, 125 patients and 360 FDR were available for study, and completed a postal questionnaire about axSpA features. FDRs were asked to report whether after 1985 they had been diagnosed by Swiss rheumatologists as having axSpA.Among HLA-B27(+) FDR, axSpA occurred in 25.4%-26.3%, independent of the radiographic sacroiliitis status of the proband. AAU occurred in 13/34 (38.2%) FDR with axSpA vs 29/251 (11.6%) FDR without axSpA (p=0.00004, OR=4.74 95% CI 2.15 to 10.47). The presence of CIBP at baseline did not predict later occurrence of axSpA but combining CIBP and pain/discomfort at the thoracic spine and at anterior (ventral) chest wall ever, assessed at follow-up in 2018-2019, provided 83.1% sensitivity and 87.2% specificity for current axSpA.Occurrence of AAU among FDR of axSpA probands should prompt screening for axSpA. Moreover, co-occurrence of CIBP and pain/discomfort in the thoracic spine and at anterior chest wall as a three-question tool may further enhance clinical suspicion of axSpA among these FDR.
MANAGEMENT OF REFRACTORY SYMPTOMATIC PREMATURE VENTRICULAR CONTRACTIONS IN A PATIENT WITH LOUIS-DIETZ SYNDROME TYPE 3, EHLERS-DANLOS SYNDROME, AND SYSTEMIC LUPUS ERYTHEMATOSUS
Authors: Nolberto Jaramillo, Denis Malkov, Bernadette Riley, Todd J. Cohen, Seth I. Keller
Journal: Journal of the American College of Cardiology (2022)
MITOCHONDRIAL FUSION PROMOTOR ALLEVIATES BRAIN MITOCHONDRIAL DYSFUNCTION AND AMYLOID-BETA PRECURSOR PROTEIN AGGREGATION IN OBESE RATS WITH CARDIAC ISCHEMIA-REPERFUSION INJURY
Authors: Hiranya Pintana, Chayodom Maneechote, Nipon Chattipakorn, Siriporn Chattipakorn
Journal: Journal of the American College of Cardiology (2022)
MXene‐Enhanced Chitin Composite Sponges with Antibacterial and Hemostatic Activity for Wound Healing
Authors: Shanshan Li, Bin Gu, Xiaoyun Li, Shuwei Tang, Lu Zheng, Eduardo Ruiz‐Hitzky, Zeyu Sun, Changliang Xu, Xiaoying Wang
Journal: Advanced Healthcare Materials (2022)

This study shows the effective use of MXene-based nanomaterials to improve the performance of biocomposite sponges in wound healing. In this way, diverse chitin/MXene composite sponges are fabricated by incorporating MXene-based nanomaterials with various morphology (accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer) into the network of chitin sponge (CH), which can prevent massive blood losses and promote the healing process of bacterial-infected wounds. With the addition of MXene-based nanomaterials, the hemostatic efficacy of CH is enhanced due to the improved hemophilicity and accelerated blood coagulation kinetics. Furthermore, the composite sponges show a predominant antibacterial activity through the synergy between the capture and the photothermal effects. Importantly, the addition of AuNPs to composite sponges further improves hemostatic performance and promotes normal skin cell migration to heal the infected wound, achieving wound closure rates of 84% on day 9. These initial studies expand the applications of MXene-based nanomaterials in biomedical fields.
Magnetic resonance imaging contrast-enhancement with superparamagnetic iron oxide nanoparticles amplifies macrophage foam cell apoptosis in human and murine atherosclerosis
Authors: Filip M E Segers, Adele V Ruder, Marijke M Westra, Twan Lammers, Seyed Mohammadali Dadfar, Karolin Roemhild, Tin Sing Lam, Marianne Eline Kooi, Kitty B J M Cleutjens, Fons K Verheyen, Geert W H Schurink, Guido R Haenen, Theo J C van Berkel, Ilze Bot, Bente Halvorsen, Judith C Sluimer, Erik A L Biessen
Journal: Cardiovascular Research (2022)

Abstract Aims (Ultra) Small superparamagnetic iron oxide nanoparticles, (U)SPIO, are widely used as magnetic resonance imaging contrast media and assumed to be safe for clinical applications in cardiovascular disease. As safety tests largely relied on normolipidaemic models, not fully representative of the clinical setting, we investigated the impact of (U)SPIOs on disease-relevant endpoints in hyperlipidaemic models of atherosclerosis. Methods and results RAW264.7 foam cells, exposed in vitro to ferumoxide (dextran-coated SPIO), ferumoxtran (dextran-coated USPIO), or ferumoxytol [carboxymethyl (CM) dextran-coated USPIO] (all 1 mg Fe/mL) showed increased apoptosis and reactive oxygen species accumulation for ferumoxide and ferumoxtran, whereas ferumoxytol was tolerated well. Pro-apoptotic (TUNEL+) and pro-oxidant activity of ferumoxide (0.3 mg Fe/kg) and ferumoxtran (1 mg Fe/kg) were confirmed in plaque, spleen, and liver of hyperlipidaemic ApoE−/− (n = 9/group) and LDLR−/− (n = 9–16/group) mice that had received single IV injections compared with saline-treated controls. Again, ferumoxytol treatment (1 mg Fe/kg) failed to induce apoptosis or oxidative stress in these tissues. Concomitant antioxidant treatment (EUK-8/EUK-134) largely prevented these effects in vitro (−68%, P &amp;lt; 0.05) and in plaques from LDLR−/− mice (−60%, P &amp;lt; 0.001, n = 8/group). Repeated ferumoxtran injections of LDLR−/− mice with pre-existing atherosclerosis enhanced plaque inflammation and apoptosis but did not alter plaque size. Strikingly, carotid artery plaques of endarterectomy patients who received ferumoxtran (2.6 mg Fe/kg) before surgery (n = 9) also showed five-fold increased apoptosis (18.2 vs. 3.7%, respectively; P = 0.004) compared with controls who did not receive ferumoxtran. Mechanistically, neither coating nor particle size seemed accountable for the observed cytotoxicity of ferumoxide and ferumoxtran. Conclusions Ferumoxide and ferumoxtran, but not ferumoxytol, induced apoptosis of lipid-laden macrophages in human and murine atherosclerosis, potentially impacting disease progression in patients with advanced atherosclerosis.
OUTCOMES OF MITRACLIP IN NONRESPONDERS TO CARDIAC RESYNCHRONIZATION THERAPY (CRT): A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Anan Abu Rmilah, Maen Assali, Mohammad Abdelhafez, Abdalla Kara Balla, Soban Ahmad, Omar Latif, Ikram Haq, Hossam Alzu’Bi, Ahmad Al-Abdouh, Suhaib jaber, Mayra E. Guerrero
Journal: Journal of the American College of Cardiology (2022)
Gorlin Syndrome: Assessing Genotype-Phenotype Correlations and Analysis of Early Clinical Characteristics as Risk Factors for Disease Severity
Authors: Nicolas J. Betancourt, Mollie F. Qian, Jean R. Pickford, Irene Bailey-Healy, Jean Y. Tang, Joyce M.C. Teng
Journal: Journal of Clinical Oncology (2022)

Gorlin syndrome (GS) is a rare genetic disorder characterized by lifetime risk of basal cell carcinomas (BCCs), skeletal anomalies (SAs), and other extracutaneous neoplasms. There is great variation in disease severity, and a genotype-phenotype correlation has not been well established. Here, we investigate whether patients' clinical characteristics predict disease severity to inform clinical decision making.Data of 248 patients with GS were collected between 2014 and 2021 from three institutions. Multivariable regression analyses were performed to investigate whether clinical characteristics predicted disease burden. Genotype-phenotype correlations were investigated in 40 patients.Patients with SAs had a mean increase of 120 lifetime BCCs (95% CI, 27.1 to 213) relative to patients without SAs. Those with ≥ 2 SAs had 2.45 increased odds (95% CI, 1.01 to 5.91) of advanced or metastatic BCCs. Moreover, the presence of multiple SAs was associated with 5.00 increased odds of having a keratocystic odontogenic tumor (95% CI, 2.22 to 11.3) and 2.79 increased odds of an ovarian fibroma (95% CI, 1.05 to 7.40). Genotype-phenotype analyses showed that missense/in-frame mutations were more likely to be hereditary compared with severe deleterious mutation types (100% v 27%; P = .004). In addition, heat map visualization illustrated that those with more deleterious variants, like large deletions, trended toward increased burden of SAs and BCCs per year.GS patients with SAs may be at greater risk for developing more numerous and severe BCCs and other neoplastic growths including keratocystic odontogenic tumors and ovarian fibromas. Current clinical guidelines suggest yearly follow-up in individuals with GS. Since SAs are usually recognized at the time of diagnosis, our results suggest that more vigilant lifetime multidisciplinary surveillance should be considered for these patients starting in childhood.
SEX-SPECIFIC DIFFERENCES IN AORTIC VALVE COMPOSITION QUANTIFIED FROM COMPUTED TOMOGRAPHY ANGIOGRAPHY IN SEVERE AORTIC STENOSIS
Authors: Kajetan Grodecki, Zenon Huczek, Andrew Lin, Marcin Protasiewicz, Andrzej Walczak, Jagielak Dariusz, Marek Grygier, Janusz Kochman, Wojciech Wojakowski, Damini Dey
Journal: Journal of the American College of Cardiology (2022)
177Lu-DOTATATE PRRT for Multiple Unusual Metastatic Sites in Neuroendocrine Tumor
Authors: Rahul V. Parghane, Sandip Basu
Journal: Clinical Nuclear Medicine (2022)

Thyroid gland and orbit are rare sites of metastases in neuroendocrine tumors. We present an extremely rare case of rectal neuroendocrine tumor with metastases to thyroid gland and intra-orbital regions that demonstrated significant reduction in size and uptake of the lesions on somatostatin receptor based 68 Ga-DOTATATE PET/CT, following 177 Lu-DOTATATE peptide receptor radionuclide therapy. The case illustrates the efficacy of 177 Lu-DOTATATE peptide receptor radionuclide therapy for tumor cytoreduction, which can be considered as a promising treatment modality for somatostatin receptor expressing and tracer-avid metastatic lesions at multiple rare locations.
Tranexamic Acid and Diffusion-Weighted Imaging Lesions After Intracerebral Hemorrhage
Authors: Stephanie E. Oh, Santosh B. Murthy
Journal: JAMA Neurology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Mental Stress–Induced Myocardial Ischemia and Cardiovascular Events in Patients With Coronary Heart Disease—Reply
Authors: Viola Vaccarino, J. Douglas Bremner, Arshed A. Quyyumi
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OPTIMAL MEDICAL THERAPY FOR PATIENTS WITH ACUTE MYOCARDIAL INFARCTION BEYOND ONE YEAR AFTER THE INITIAL ATTACK
Authors: Seung-Jae Joo, Ki Yung Boo, Jong-Wook Beom, Jae-Geun Lee, Joon-Hyouk Choi, Song-Yi Kim, Myung Ho Jeong
Journal: Journal of the American College of Cardiology (2022)
P-WAVE DURATION AND ATRIAL FIBRILLATION RECURRENCE AFTER CATHETER ABLATION. AN UPDATED SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Sotirios Nedios, Konstantinos Zagoridis, Stergios Intzes, Marianthi Symeonidou, Emmanouil Spanoudakis, Arash Arya, Borislav Dinov, Nikolaos Dagres, Andreas Bollmann, Emanouel Koutalas, Gerhard Hindricks
Journal: Journal of the American College of Cardiology (2022)
Predictive Models for Acute Kidney Injury Following Cardiac Surgery
Authors: Marlies Ostermann, Nuttha Lumlertgul, Francis Perry Wilson
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endoscopic sinusotomy using the small-ceramic-tip-insulated electrosurgical knife for chronic pouch sinus after ileal pouch anal anastomosis in ulcerative colitis: a case report
Authors: Hidenori Tanaka, Shiro Oka, Ken Yamashita, Ryohei Hayashi, Yusuke Watadani, Hiroki Ohge, Shinji Tanaka
Journal: Endoscopy (2022)

A 23-year-old man with a history of total colectomy and ileal pouch anal anastomosis for ulcerative colitis had a presacral sinus opening along the suture line of the ileal pouch after surgery that had been performed 2 years previously ([Fig. 1], [Fig. 2]). Computed tomography-guided drainage, endoscopic sinus clipping closure, and transanal sinusotomy were performed; however, repeated amidotrizoic acid enema indicated a persistent presacral pouch sinus. Consequently, endoscopic sinusotomy was performed to unify the sinus and the ileal pouch ([Video 1]).
Loss of SIRT5 promotes bile acid-induced immunosuppressive microenvironment and hepatocarcinogenesis
Authors: Renqiang Sun, Zhiyong Zhang, Ruoxuan Bao, Xiaozhen Guo, Yuan Gu, Wenjing Yang, Jinsong Wei, Xinyu Chen, Lingfeng Tong, Jian Meng, Chen Zhong, Cheng Zhang, Jinye Zhang, Yiping Sun, Chen Ling, Xuemei Tong, Fa-Xing Yu, Hongxiu Yu, Weifeng Qu, Bing Zhao, Wei Guo, Maoxiang Qian, Hexige Saiyin, Ying Liu, Rong-Hua Liu, Cen Xie, Weiren Liu, Yue Xiong, Kun-Liang Guan, Yinghong Shi, Pu Wang, Dan Ye
Journal: Journal of Hepatology (2022)
LIPID LOWERING THERAPY AND ATTAINMENT OF LIPID GOALS ACCORDING TO 2018 ACC/AHA AND 2019 ESC/EAS GUIDELINES ON PATIENTS WITH ASCVD ON A REAL-WORLD MEXICAN POPULATION
Authors: Frida Vizcaino, Manuel Odin De Los Rios Ibarra, Jose Luis Leiva Pons, Humberto Rodriguez Reyes, Marco Antonio Alcocer Gamba, Jorge Cortes Lawrenz, Marisol Lugo Gavidia, Jaime Barragan Luna
Journal: Journal of the American College of Cardiology (2022)