tbuckley/cabot-search huggingface dataset:
Continuous local electrical activity. A mechanism of recurrent ventricular tachycardia.
Authors: M EJosephson, L NHorowitz, AFarshidi
Journal: Circulation (1978)

Although the mechanism of most episodes of recurrent ventricular tachycardia (VT) is believed to be re-entry, definitive proof of this hypothesis has heretofore been unavailable in man. Using programmed stimulation and ventricular endocardial mapping we studied three patients in whom the initiation of VT was dependent upon developing a critical degree of fractionation and delay in  left ventricular electrograms. When electrical activity spanned diastole, VT ensued. Maintenance of VT was associated with continuous electrical activity resembling local fibrillation while termination of VT required cessation of this continuous activity. During sinus rhythm the electrogram recorded from the areas which subsequently developed continuous activity showed markedly fractionated and prolonged electrical activity exceeding 100 msec in duration. We feel these observations of the temporal relationship of continuous activity with the development of VT represent the first documentation of the re-entrant nature of ...
Effect of increasing degrees of ischemic injury on myocardial oxidative metabolism early after reperfusion in isolated rat hearts.
Authors: GGörge, PChatelain, JSchaper, RLerch
Journal: Circulation Research (1991)

The present investigation studied the effect of increasing severities of ischemic injury on recovery of oxidative metabolism after reperfusion in isolated rat hearts perfused retrogradely with erythrocyte-containing medium. Hearts subjected to 60 minutes of low-flow ischemia (5% of control perfusion) exhibited delayed but sustained recovery of left ventricular pressure development during reperfusion and preservation of ultrastructure delineated with electron microscopy. Immediately after reperfusion, myocardial oxygen consumption returned to control values, well before left ventricular pressure development recovered. Early after reperfusion release of 14CO2 from [1-14C]palmitate was reduced (-53%, p less than 0.01). Conversely, release of 14CO2 from [U-14C]glucose was increased (+131%, p less than 0.05). After 60 minutes of reperfusion 14CO2 release had completely returned to normal for both labeled substrates. Pulse-labeling experiments indicated that during transient depression of [1-14C]palmitate oxida...
Visualization and quantification of transmural concentration profiles of macromolecules across the arterial wall.
Authors: M SPenn, M RKoelle, S MSchwartz, G MChisolm
Journal: Circulation Research (1990)

Transport parameters that describe a macromolecule entering the arterial wall from plasma can be obtained from concentration profiles of the labeled macromolecule entering the tissue. A new technique has been developed for measuring such concentration profiles, which offers spatial resolution superior to methods that measure profiles of radiolabeled macromolecules by serially sectioning tissue in planes parallel to the endothelium. In addition, this new method preserves cellular organization and tissue structure and permits measurement of concentration profiles underlying focal endothelial injuries or vascular lesions. The technique quantifies the concentration of a protein by measuring associated peroxidase activity. Although the present study was performed using horseradish peroxidase (HRP), the same principles can be applied to other macromolecules linked to HRP or microperoxidase. The colored reaction product of HRP was detected in transverse aortic sections using an image processing system. In the pr...
Long QT interval syndrome. A new look at an old electrocardiographic measurement--the power of the computer.
Authors: M MLaks
Journal: Circulation (1990)

Because clinical studies frequently include only a marginal number of patients, these relatively new, robust statistical techniques will have increased use. The utilization of ROC curves will be more commonplace because they permit the comprehension of the data in a more dynamic mode than merely the reporting of sensitivities and specificities.
A prospective comparison of triple extrastimuli and left ventricular stimulation in studies of ventricular tachycardia induction.
Authors: FMorady, LDiCarlo, SWinston, J CDavis, M MScheinman
Journal: Circulation (1984)

One hundred and one patients with sustained unimorphic ventricular tachycardia underwent programmed ventricular stimulation with one of two protocols. Fifty patients underwent programmed stimulation with protocol A, which consisted of burst overdrive pacing, single, double, and triple extrastimuli at the right ventricular apex, right ventricular outflow tract, or septum, and then at the left ventricular apex. Fifty-one patients underwent programmed stimulation with protocol B, which consisted of burst overdrive pacing, single and double extrastimuli at the right ventricular apex, right ventricular outflow tract or septum, and at the left ventricular apex, followed by triple extrastimuli at these sites. The stimulation protocol was continued until sustained ventricular tachycardia or rapid, polymorphic ventricular tachycardia greater than 10 sec in duration was induced. With protocol A, clinical and nonclinical ventricular tachycardia was induced in 76% and 36% of patients, respectively; with protocol B, c...
Effect of l-dopa on sympathetic nerve activity and blood pressure in the spontaneously hypertensive rat.
Authors: W VJudy, A MWatanabe, D PHenry, H RBesch, BAprison
Journal: Circulation Research (1978)

We examined the effect of L-Dopa, after peripheral L-amino acid decarboxylase inhibition, on sympathetic nerve activity (SNA) and blood pressure in spontaneously hypertensive rats (SHR) and in normotensive control rats. L-Dopa reduced SNA in both groups of animals. The SHRs were significantly more sensitive to the depressor effect of L-dopa than were the control animals, the threshold dose for reduction of SNA being 3 mg/kg in the SHR and 15 mg/kg in control rats. Similarly, the magnitude of inhibition of SNA was substantially greater in the SHR than in normotensive rats. The reduction in SNA in the SHR accompanied by a parallel fall in blood pressure. In contrast, blood pressure in control rats did not change significantly, even though SNA was diminished. Studies of the penetration of L-dopa into the cerebral parenchyma revealed that equivalent amounts of the amino acid entered the brains of the two groups of rats. These results suggest that the SHRs are more sensitive to the SNA-inhibiting effects of L-...
Extrahepatic Manifestations of Hepatitis C Virus Infection
Authors: Jose Luis Perez-Castrillon
Journal: Annals of Internal Medicine (1996)

Letters15 August 1996Extrahepatic Manifestations of Hepatitis C Virus InfectionJose Luis Perez-Castrillon, MD and Miguel Martin-Luguero, MDJose Luis Perez-Castrillon, MDHospital Rio Hortega, Valladolid, SpainSearch for more papers by this author and Miguel Martin-Luguero, MDHospital Rio Hortega, Valladolid, SpainSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-4-199608150-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Gumber and Chopra [1] wrote an excellent review of extrahepatic manifestations of HCV infection. However, the review does not mention the association between HCV infection and B-cell non-Hodgkin lymphoma.Ferri and colleagues [2] showed the presence of HCV infection in 17 patients (30%) of 50 unselected patients with B-cell non-Hodgkin lymphoma. Cryoglobulinemia was detected in 8% of these patients. This association is particularly significant compared with the prevalence of HCV infection in the healthy Italian population (1.3%). Pozzato and associates [3] showed a high prevalence of non-Hodgkin lymphoma in patients with cryoglobulinemia and HCV infection. The presence ...References1. Gumber SC, Chopra S. Hepatitis C: a multifaceted disease. Review of extrahepatic manifestations. Ann Intern Med. 1995; 123:615-20. Google Scholar2. Ferri C, Caracciolo F, Zignegno AL, La Civita L, Monti M, Longombardo G, et al. Hepatitis C virus infection in patients with non-Hodgkin's lymphoma. Br J Haematol. 1994; 88:392-4. Google Scholar3. Pozzato G, Mazzaro C, Crovatto M, Modolo ML, Ceselli S, Mazzi G, et al. Low-grade malignant lymphoma, hepatitis C virus infection, and mixed cryoglobulinemia. Blood. 1994; 84:3047-53. Google Scholar4. Ferri C, Monti M, La Civita L, Longombardo G, Greco F, Pasero G, et al. Infection of peripheral blood mononuclear cells by hepatitis C virus in mixed cryoglobulinemia. Blood. 1993; 82:3701-4. Google Scholar Author, Article, and Disclosure InformationAuthors: Jose Luis Perez-Castrillon, MD; Miguel Martin-Luguero, MDAffiliations: Hospital Rio Hortega, Valladolid, Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAssessment of total hepatitis C virus (HCV) core protein in HCV-related mixed cryoglobulinemiaHepatitis C Virus Glycoproteins Interact with DC-SIGN and DC-SIGNR 15 August 1996Volume 125, Issue 4Page: 344-345KeywordsB cellsHepatitis C virusInfectious hepatitisLymphocytesLymphoma ePublished: 15 August 2000 Issue Published: 15 August 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
From the authors
Authors: N.S.W.T. Tay
Journal: European Respiratory Journal (2006)

In a recent issue of the European Respiratory Journal, TAY et al. [1] presented the interesting article on rather rare cases of paragonimiasis in Europe.Taking into consideration tourist activity and growing numbers of oriental restaurants, the probability of this type of infestation in our region is constantly increasing.However, this case is presented from the aspect of differential diagnosis with tuberculosis (TB) and, therefore, requires some comments.
Synergistic multiple early therapy (SMET) for inflammatory diseases with pathogenic autoinflammatory feedback circuits
Authors: J.P. McFadden, L.S. Cunningham, F.J. Ferguson, C. Tziotzios, J.A. McGrath
Journal: British Journal of Dermatology (2021)

Linked Comment: Marzano et al. Br J Dermatol 2021; 185:133–140.
Transluminal, subselective measurement of coronary artery blood flow velocity and vasodilator reserve in man.
Authors: R FWilson, D ELaughlin, P HAckell, W MChilian, M DHolida, C JHartley, M LArmstrong, M LMarcus, C WWhite
Journal: Circulation (1985)

Assessment of coronary blood flow and the vasodilator reserve capacity of individual coronary arteries in the catheterization laboratory has been hampered by methodologic limitations. We have developed and validated a small Doppler catheter that can subselectively measure phasic coronary blood flow velocity (CBFV). In seven anesthetized calves, CBFV was varied from 0.1 to 5.7 times control CBFV. Changes in mean CBFV measured intraluminally by catheter in the left anterior descending and left circumflex arteries were similar to those measured simultaneously with an epicardial Doppler probe on the surface of the same vessel (n = 85, r = .95, slope = 1.04) and to changes in coronary sinus flow (n = 69, r = .97, slope = 1.06) measured with timed venous collections. Identical maximal coronary reactive hyperemic responses with the catheter present and absent in the artery being studied demonstrated that coronary obstruction by the catheter was minimal. Safety studies in six additional calves demonstrated that t...
Association of a Genetic Risk Score With Body Mass Index—Reply
Authors: M. Maria Glymour, Stefan Walter, Iván Mejía-Guevara
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sleep quality as a confounding factor of maternal weight and preschool wheezing
Authors: K. T. Nozoe, D. N. Polesel, A. C. Boin, G. A. Moreira, S. Tufik, M. L. Andersen
Journal: European Respiratory Journal (2014)

To the Editor: 

We read with great interest the recently published article by Leermakers et al. [1] that takes an outstanding view of the relationship of maternal weight with the risk of preschool wheezing. We would like to highlight the importance of this study, as it shows a bidirectional interaction between pregnancy and childhood health. Moreover, we would like to congratulate the authors on the accomplishment of this research and suggest additional considerations for further investigations.

Currently, asthma is the most common chronic disease in children in the USA. It is noteworthy that the incidence of asthma in childhood has progressively increased, being observed 8.7% of cases in 2001 and 9.6% in 2009 [2]. For instance, 17% of children in the USA have a diagnosis of obesity and there is a higher prevalence of asthma in obese children [3]. …
The mechanisms of nitroglycerin action: stenosis vasodilatation as a major component of the drug response.
Authors: B GBrown, EBolson, R BPetersen, C DPierce, H TDodge
Journal: Circulation (1981)

The effect of sublingual or intracoronary nitroglycerin (NTG) on luminal caliber in  and diseased portions of epicardial coronary arteries was determined in 85 lesions from 57 typical patients with ischemic heart disease. Measurements were made from coronary angiograms, using a computer-assisted method and a carefully blinded protocol for analysis of the pre- and post- NTG angiograms. Luminal area in the normal portion of the diseased segment and at its maximum constriction and an estimate of flow resistance in the stenosis were computed. Luminal area increased 1.27 mm2 (p less than 0.001) in the normal regions, an average increase of 18% over the control area. Dilation with NTG depended strongly on vessel size; area increased 35% in  vessels of 1.6-2.3 mm luminal diameter and only 9% in vessels 4.0-5.0 mm in diameter. Lesions were grouped into four levels of severity by percent stenosis. Minimum luminal area increased 0.35 mm2 (p less than 0.01) at the narrowest point in moderate lesions,...
Physiological pH. Effects on posthypoxic proximal tubular injury.
Authors: R AZager, B ASchimpf, D JGmur
Journal: Circulation Research (1993)

After O2 deprivation, tissue acidosis rapidly self-corrects. This study assessed the effect of this pH correction on the induction, and pathways, of posthypoxic proximal tubular injury. In addition, ways to prevent the resultant injury were explored. Isolated rat proximal tubular segments (PTSs) were subjected to hypoxia/reoxygenation (50/30 or 30/50 minutes) under the following incubation conditions: 1) continuous pH 7.4, 2) continuous pH 6.8, or 3) hypoxia at pH 6.8 and reoxygenation at pH 7.4 (NaHCO3 or Tris base addition). Continuously oxygenated PTSs maintained under these same pH conditions served as controls. Lethal cell injury was assessed by lactate dehydrogenase (LDH) release. pH effects on several purported pathways of hypoxia/reoxygenation injury were also assessed (ATP depletion, lipid peroxidation, and membrane deacylation). Acidosis blocked hypoxic LDH release (pH 7.4, 50 +/- 2%; pH 6.8, 6 +/- 1%) without mitigating membrane deacylation or ATP depletion. During reoxygenation, minimal LDH wa...
Asymptomatic coronary artery disease: angiographic assessment of diabetics evaluated for renal transplantation.
Authors: LWeinrauch, J AD'Elia, R WHealy, R EGleason, A RChristleib, O SLeland
Journal: Circulation (1978)

Twenty-one insulin-dependent diabetics with azotemic nephropathy were evaluated for renal transplantation by selective coronary angiography and cine left ventriculography. All had hypertension, retinopathy, neuropathy, and required salt restriction plus diuretics for volume overload. There was no clinical or electrocardiographic evidence of ischemic coronary artery disease in twenty. Ten patients (five males, five females, mean age 29.3 years; mean duration of diabetes 21.9 years; mean serum cholesterol 239 mg%) had significant coronary artery disease, seven demonstrating focal abnormalities in left ventricular wall motion. Two patients (one male, one female; mean age 36.5 years; mean duration of diabetes 28.5 years; mean serum cholesterol 250 mg%) had no significant coronary artery disease, but demonstrated diffusely abnormal left ventricular wall motion with diminished ejection fraction. Thirty-eight percent had significant coronary artery disease unpredictable by electrocardiographic or clinical data. ...
Surgical ablation of ventricular tachycardia with sequential map-guided subendocardial resection: electrophysiologic assessment and long-term follow-up.
Authors: D EHaines, B BLerman, I LKron, J PDiMarco
Journal: Circulation (1988)

A new operative technique of sequential map-guided subendocardial resection (SER) was used in 45 consecutive patients for the treatment of sustained ventricular tachycardia due to coronary artery disease. This technique is characterized by map-guided SER or cryothermic ablation during normothermic cardiopulmonary bypass, followed by repeated sequences of programmed stimulation to assess adequacy of resection. The patients' mean age was 59 +/- 10 years and the mean left ventricular ejection fraction was 34 +/- 12%. Twenty-five (56%) patients had a history of myocardial infarction within the previous 2 months. After ventriculotomy, 34 patients (76%) had inducible monomorphic ventricular tachycardia. These patients underwent repeated sequences of ventricular tachycardia induction and mapping during normothermic bypass followed by successive SER or cryothermic ablation until sustained monomorphic ventricular tachycardia was no longer inducible. Twenty-seven patients had a total of 60 discrete, mappable tachyc...
Effects of the antibiotic ionophore X-537A on contractility and ionic exchange in rabbit ventricular myocardium.
Authors: I RWendt, G ALanger
Journal: Circulation Research (1977)

The effects of the ionophore X-537A on mechanical function and on ionic exchange were studied in the isolated, arterially perfused rabbit interventricular septum. X-537A produced an initial positive inotropic response which was, however, transient in this preparation and appeared to be dependent on an effect of the ionophore on catecholamines. The positive inotropy gave way to a progressive decline in force development which was unrelated to the action of catecholamines and was not accompanied by the development of contracture. Isotope uptake experiments revealed that coincident with this decline in force development there was a continuous net loss of tissue K+ and a net gain of Na+. X-537A (5 micronM) perfused for 20 minutes resulted in a net K+ loss of 50.2 +/- 4.6 mmol/kg dry weight and a net Na+ gain of 74.0 +/- 4.5 mmol/kg dry weight. Isotope washout experiments confirmed that the entire net loss of K+ could be accounted for by increased K+ efflux. X-537A did not alter Na+ efflux nor did it have any ...
Turbulent blood flow in the ascending aorta of humans with normal and diseased aortic valves.
Authors: P DStein, H NSabbah
Journal: Circulation Research (1976)

Turbulent blood flow may contribute to a variety of pathophysiological effects. Because of its postulated importance, this study was undertaken to determine whether turbulent flow does in fact occur in the human body. In 15 persons (seven normal, seven aortic valvular disease, one prosthetic aortic valve), point velocity was measured in the ascending aorta with a hot-film anemometer probe. In one normal individual with a high cardiac output, turbulent flow occurred above the aortic valve during peak flow which corresponded to a peak Reynolds number of 10,000. In the other six normal subjects (peak Reynolds numbers of 5,700-8,900), flow was highly disturbed during peak ejection. Each of the subjects with aortic valvular disease and the subject with a prosthetic aortic valve showed turbulent flow during nearly the entire period of ejection, with Fourier components of velocity of significant magnitude up to 320 Hz (the maximum frequency we could evaluate with the equipment available). The turbulence energy d...
Effect of intranasal corticosteroid treatment on allergen‐induced changes in group 2 innate lymphoid cells in allergic rhinitis with mild asthma
Authors: Yanqing Xie, Xiaotian Ju, Suzanne Beaudin, Lesley Wiltshire, John Paul Oliveria, Jonathan MacLean, Doron D. Sommer, Ruth Cusack, Olga Li, Prajna Banerjee, Paul K. Keith, Paul M. O'Byrne, Rebecca N. Bauer, Tracy Staton, Gail M. Gauvreau, Roma Sehmi
Journal: Allergy (2021)

Abstract Background Allergic rhinitis is characterized by rhinorrhea, nasal congestion, sneezing and nasal pruritus. Group 2 innate lymphoid cells (ILC2s), CD4 + T cells and eosinophils in nasal mucosa are increased significantly after nasal allergen challenge (NAC). Effects of intranasal corticosteroids (INCS) on ILC2s remain to be investigated. Methods Subjects ( n = 10) with allergic rhinitis and mild asthma were enrolled in a single‐blind, placebo‐controlled, sequential treatment study and treated twice daily with intranasal triamcinolone acetonide (220 µg) or placebo for 14 days, separated by a 7‐day washout period. Following treatment, subjects underwent NAC and upper airway function was assessed. Cells from the nasal mucosa and blood, sampled 24 h post‐NAC, underwent flow cytometric enumeration for ILC2s, CD4 + T and eosinophil progenitor (EoPs) levels. Cell differentials and cytokine levels were assessed in nasal lavage. Results Treatment with INCS significantly attenuated ILC2s, IL‐5 + /IL‐13 + ILC2s, HLA‐DR + ILC2s and CD4 + T cells in the nasal mucosa, 24 h post‐NAC. EoP in nasal mucosa was significantly increased, while mature eosinophils were significantly decreased, 24 h post‐NAC in INCS versus placebo treatment arm. Following INCS treatment, IL‐2, IL‐4, IL‐5 and IL‐13 were significantly attenuated 24 h post‐NAC accompanied by significant improvement in upper airway function. Conclusion Pre‐treatment with INCS attenuates allergen‐induced increases in ILC2s, CD4 + T cells and terminal differentiation of EoPs in the nasal mucosa of allergic rhinitis patients with mild asthma, with little systemic effect. Attenuation of HLA‐DR expression by ILC2s may be an additional mechanism by which steroids modulate adaptive immune responses in the upper airways.
Ultrasensitive point-of-care immunoassay for secreted glycoprotein detects Ebola infection earlier than PCR
Authors: Cassio M. Fontes, Barbara D. Lipes, Jason Liu, Krystle N. Agans, Aiwei Yan, Patricia Shi, Daniela F. Cruz, Garrett Kelly, Kelli M. Luginbuhl, Daniel Y. Joh, Stephanie L. Foster, Jacob Heggestad, Angus Hucknall, Maiken H. Mikkelsen, Carl F. Pieper, Roarke W. Horstmeyer, Thomas W. Geisbert, Michael D. Gunn, Ashutosh Chilkoti
Journal: Science Translational Medicine (2021)

An immunoassay that targets the nonstructural secreted glycoprotein decoy antigen of Ebola virus detects infection earlier than PCR.