tbuckley/cabot-search huggingface dataset:
JAMA Cardiology
Authors: Phil Fontanarosa, Annette Flanagin, Brenda Gregoline, Tracy Frey, Iris Lo, Kevin Brown, Amanda Ehrhardt, M Newman, Suzanne Walker, Connie Manno Senior, Sara Billings, Timothy Gray, Juliet Orellana, Paul Ruich, Kirby Snell, Catherine Alden, Stephanie Beckmeyer, Jane Calayag, Jan Clavey, Mary Coerver-Connolly, Paula Glitman, Bernadette Hromin, Paul Jaworski, Laura King, Regina Lilly, Molly O'donnell, Charon Pierson, Thressa Smith, Divya Sreekumar, Donna Thordsen, Christine Tilles, Caroline Woods, Editorial Assistant, Wanda Hill, Larry Bryant, Jacob Kendall-Taylor, Monica Managers, Fanny Staff, Anna Brown, Lee Bukowski, Lenette Calibeo, Tosca Gardner-Gullens, Erin Hall, Rachell Kato, Caroline Lozano, Angelia Sietmann, Michael Berkwits, Eric Butkus, Jesse Mcquarters, Elena Guobyte, Emily Ling, Daniel Morrow, Social Media, Eman Hassaballa, Reuben Rios, Mary Ferkaluk, Karen Bucher, Andy Rekito, Nick Reback, Lohitha Kethu, David Song, Deputy Livingston, Thomas Cole, Marla Hall, Deanna Willis, Yolanda Davis, Joseph Thornton, Deanna Bellandi, Jim Periodical, Thomas Easley, Brian Shields, Karen Adams-Taylor, Paul Gee, Monica Smith, Jeff Ery, J Bonistalli, Kathy Russell, Mirna Monal, Stacey Mchugh, Tim Melroy, Marketing Thornbury, Tricia Castellano, Anna Manager, Thalia Moss, Sade Deramus-Townsend, Tony Ralenkotter, Marsha Fogler, Rachel Sisholtz, Saskia Bolore, Gretchen Linder, Brian Mccartney, Christine Hearne, Natasha Staff, Henry Aguillon, David Baum, Ron Thomas, Rick Bell, Elizabeth Solaro, Sara Zimmerman, Geoff Rey, Lindsay Dawson, Ellen Gibson, Sam Ismail, Craig Mccaff Rey, Michael Mcgraw, Daniel Pickhardt, Romando Rossini, Sarah Subramanian, Stacy Business, Analyst Sirisha, Alluri Staff, Millette Jackson-Bates, Tom Miller, Jacob Mishkin, Morgan Osgood, James Madara, Howard Bauchner, Robert Bonow, Patrick O'gara, Marc Sabatine, Clyde Boston, Michael Pencina, Carolina North, Adrian Hernandez, Mhs Durham, North Carolina, Mark Huff Man, Ajay Kirtane, New York, Roxana Mehran, Ann Navar, Carolina Christopher, J O'donnell, Massachusetts Boston, J Sanjiv, Mintu Shah, Gregg Fonarow, Los Angeles, Elizabeth Mcnally, Laine Thomas, Akhil Narang, Julia Getts, Eugene Braunwald, Robert Califf, Judith Hochman, Donald Lloyd-Jones, Scm Chicago, Michael Parmacek, Daniel Simon, Sidney Smith, Chapel Hill, Carolina Douglas, E Vaughan, Myron Weisfeldt, Maryland Douglas, P Zipes, Paul Armstrong, Shinya Goto, Peter Liu, Renato Lopes, Carolina Maseri, Dorairaj Prabhakaran, Hugh Watkins, Harvey White, Habib Yacoub
Journal: JAMA Cardiology (2020)
Sudoku of porous, injectable calcium phosphate cements – Path to osteoinductivity
Authors: Agneta Vezenkova, Janis Locs
Journal: Bioactive Materials (2022)

With the increase of global population, people's life expectancy is growing as well. Humans tend to live more active lifestyles and, therefore, trauma generated large defects become more common. Instances of tumour resection or pathological conditions and complex orthopaedic issues occur more frequently increasing necessity for bone substitutes. Composition of calcium phosphate cements (CPCs) is comparable to the chemical structure of bone minerals. Their ability to self-set and resorb in vivo secures a variety of potential applications in bone regeneration. Despite the years-long research and several products already reaching the market, finding the right properties for calcium phosphate cement to be osteoinductive and both injectable and suitable for clinical use is still a sudoku. This article is focused on injectable, porous CPCs, reviewing the latest developments on the path toward finding osteoinductive material, which is suitable for injection.
Prognostic impact of common pathologic alterations in pancreatic ductal adenocarcinoma from the veterans health administration.
Authors: Eric Glenn Mehlhaff, Syed Nabeel Zafar, Dyan M. Lesnik, Noelle K. LoConte, Sam Joseph Lubner, Jeremy D. Kratz
Journal: Journal of Clinical Oncology (2022)

603 Background: The Veteran Health Administration’s (VHA) National Precision Oncology Program was established to provide comprehensive molecular profiling for US military veterans with advanced cancers. There is an urgent need for precision strategies in pancreatic ductal adenocarcinoma (PDAC), as it is a leading cause of cancer-related mortality. We hypothesized that contributions of molecular alterations in PDAC would fail to stratify overall survival (OS), as current strategies are largely dependent on the activity of cytotoxic chemotherapy. Methods: A retrospective, multicenter cohort of 342 veterans with PDAC were identified from January 2016 to March 2021 who underwent comprehensive next-generation sequencing of tumor using FoundationOne CDx (UW IRB#2020-0696). Subjects were stratified by localized (L) or metastatic (M) disease at the time of diagnosis. Molecular alterations were compared by disease presentation using chi-squared analysis, and the clinical outcomes of overall survival (OS) were evaluated using Student’s t-test. Results: Baseline characteristics were representative of the VA population across 80 independent sites. The cohort was male-dominant (97%) with a median age of 69 years at diagnosis. Of this sample, 55% had M disease (n=189) compared to 45% with L disease (n=153). Median OS for M PDAC was 8.9±10.2 months (mo) v. L PDAC with median OS 22.5±18.0 mo (p&lt;0.00005). Primary driver alterations were representative of PDAC and comparable between L and M on presentation, respectively; these included KRAS (92% v. 91%), TP53 (73% v. 80%), CDKN2A (29% v. 32%), SMAD4 (18% v. 23%), ARID1A (15% v. 16%) and BRCA2 (9% v. 12%). Primary driver alterations did not confer differences in OS across the population when comparing mutant (mt) to wildtype (wt) for KRAS (10.7 v. 11.8 mo, n=312), TP53 (10.3 v. 11.8 mo, n=263), CDKN2A (10.2 v. 10.9 mo, n=105), ARID1A (10.8 v. 10.9 mo, n=53), SMAD4 (11.3 vs 10.7 mo, n=72), and BRCA2 (13.8 v. 10.7 mo, n=37). Conclusions: Using the largest report of molecular profiles in veterans with PDAC to date, current therapeutic strategies fail to differentiate clinical outcomes by common molecular alterations with cytotoxic chemotherapy. The molecular profiles of veterans are representative of PDAC and do not vary significantly between localized and metastatic disease. There remains a persistent unmet need for therapeutic strategies including ongoing investigations of novel metabolic and immune-based therapies.
Der photographische Prozess.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 300: Topical Application of IcyHot Reduces Myocardial Infarct Size in Rodents by a TRPA1-dependent Mechanism
Authors: Yun Wu, Yao Lu, Eric R Gross
Journal: Circulation Research (2017)

Toxic reactive aldehydes are formed during ischemia-reperfusion. The ion channel transient receptor potential ankryin 1 (TRPA1) is irreversibly modified by reactive aldehydes which can cause calcium influx and cell death. Here we tested whether topically applied creams containing a reversible TRPA1 agonist could reduce myocardial infarct size. Male Sprague-Dawley rats 8-10 weeks age were subjected to an in vivo myocardial ischemia-reperfusion model of 30 minutes of left anterior descending (LAD) coronary artery ischemia followed by 2 hours reperfusion. Prior to ischemia, rats were untreated or had 1g of cream applied to the abdomen. The creams tested were IcyHot, Bengay, Tiger Balm, or preparation H (Fig. 1A). Hearts were negatively stained for the area at risk and the infarct size was determined by using TTC staining (Fig. 1B). A subset of rodents prior to receiving IcyHot also received an intravenous bolus of the TRPA1 antagonist TCS-5861528 (1mg/kg) or AP-18 (1mg/kg). Interestingly, both IcyHot and Bengay reduced myocardial infarct size compared to untreated rodents (Fig. 1C and 1D IcyHot: 41±3%*, Bengay: 50±2%* versus control 62±1%, n=6/group, *P&lt;0.001). Both preparation H and Tiger Balm failed to reduce myocardial infarct size (Tiger Balm: 63±2%, preparation H 59±2%). Giving a TRPA1 antagonist prior to IcyHot also blocked the reduction in infarct size. Our additional data also indicates the methyl salicylate (mint) in IcyHot and Bengay is the agent that limits myocardial infarct size. Since IcyHot and Bengay are safely used by humans, targeting TRPA1 by using products such as these could be quickly translatable and widely used to reduce ischemia-reperfusion injury.
Amplifying the Voice of the Whispering Cancer
Authors: Neesha C. Dhani
Journal: Clinical Cancer Research (2021)

Abstract Nontargeted circulating tumor DNA (ctDNA) whole-genome sequencing is a novel strategy for genomic characterization of high-grade serous ovarian cancer. Changes in ctDNA levels are a sensitive indicator of disease burden with an average lead time of 6 months to clinical progression. This presents a unique opportunity to identify pathways driving progression as molecular vulnerabilities for clinical drug development. See related article by Paracchini et al., p. 2549
The Gut Microbiome as a Regulator of the Neuroimmune Landscape
Authors: Lewis W. Yu, Gulistan Agirman, Elaine Y. Hsiao
Journal: Annual Review of Immunology (2022)

The gut microbiome influences many host physiologies, spanning gastrointestinal function, metabolism, immune homeostasis, neuroactivity, and behavior. Many microbial effects on the host are orchestrated by bidirectional interactions between the microbiome and immune system. Imbalances in this dialogue can lead to immune dysfunction and immune-mediated conditions in distal organs including the brain. Dysbiosis of the gut microbiome and dysregulated neuroimmune responses are common comorbidities of neurodevelopmental, neuropsychiatric, and neurological disorders, highlighting the importance of the gut microbiome-neuroimmune axis as a regulator of central nervous system homeostasis. In this review, we discuss recent evidence supporting a role for the gut microbiome in regulating the neuroimmune landscape in health and disease.
Physicians Impersonated.
Authors: Walter P. Porcher
Journal: JAMA (1900)

Charleston, S. C., Nov. 14, 1900. <h3>To the Editor:</h3> —Dr. A. R. Shands, of Washington, D. C., secretary of the committee on arrangements of the last American Congress of Physicians and Surgeons, writes me that a man, claiming to be myself, and to have attended the meeting of the congress in May last, has been victimizing many of the profession of that city by pretending to be in distress and borrowing money from them. He claims to have many friends in Richmond, Va. The doctor describes the man as between 60 and 70 years old, clean face, heavy gray mustache, about 5 feet 10 inches tall, and rather spare build. I know of men, in other cities, in former years, who have been victimized in a similar manner, and in one instance the thief proved to be a former governor of this state under carpet-bag rule, and the above description
TCT-194 Impact of Intravascular Imaging Methods for Optimal Scaffold Implantation Reducing Thrombosis After Absorb BVS in a Real World Setting: Identification of Probable Factors Related to Stent Failure
Authors: Costantino Costantini, Sergio Tarbine, Costantino Ortiz, Marcelo Santos, Marcos Denk, Rafael Macedo, Marcio Luize, Joao Folador
Journal: Journal of the American College of Cardiology (2018)
Emergency medicine as an academic discipline
Authors: A. I. Sutnick
Journal: JAMA (1977)

Because of an explosive increase in the use of emergency rooms in hospitals across the country, many hospitals have found it expedient to employ full-time emergency physicians. The demand for emergency physicians has prompted the development of training programs in emergency medicine in academic medical centers. The first such training program was instituted at The Medical College of Pennsylvania in 1970. The 32 current programs in the nation are filling a real need in providing manpower for hospital emergency rooms. With the increasing identification and distribution of emergency physicians, there has been an attempt to develop emergency medicine as a distinct discipline and to establish its legitimacy in the structure of academic medical centers. A variety of problems must be addressed to clarify the role of emergency medicine in the academic setting. (<i>JAMA</i>238:147-148, 1977)
Commentaire de travail de J. Martinek et al., pp. 711
Journal: Endoscopy (2008)

See also:Low incidence of adenocarcinoma and high-grade intraepithelial neoplasia in patients with Barrett’s esophagus: a prospective cohort studyEndoscopy 2008; 40(09): 711-716DOI: 10.1055/s-2008-1077502
VENTILATION AND SCHOOL HYGIENE
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
COVID-19 Among American Indian and Alaska Native Persons — 23 States, January 31–July 3, 2020
Authors: Sarah M. Hatcher, Christine Agnew-Brune, Mark Anderson, Laura D. Zambrano, Charles E. Rose, Melissa A. Jim, Amy Baugher, Grace S. Liu, Sadhna V. Patel, Mary E. Evans, Talia Pindyck, Christine L. Dubray, Jeanette J. Rainey, Jessica Chen, Claire Sadowski, Kathryn Winglee, Ana Penman-Aguilar, Amruta Dixit, Eudora Claw, Carolyn Parshall, Ellen Provost, Aurimar Ayala, German Gonzalez, Jamie Ritchey, Jonathan Davis, Victoria Warren-Mears, Sujata Joshi, Thomas Weiser, Abigail Echo-Hawk, Adrian Dominguez, Amy Poel, Christy Duke, Imani Ransby, Andria Apostolou, Jeffrey McCollum
Journal: MMWR Morbidity and Mortality Weekly Report (2020)
Oral L-arginine improves endothelial dysfunction in patients with essential hypertension John Lekakis, Sotirios Papathanasiou, Christos Papamichael, Nicos Zakopoulos, Vassilios Kotsis, Anna Dagre, Theodoros Papaioannou, Stamatios Stamatelopoulos. Dept of Clin Therapeutics, Alexandra University Hospital, Athens, Greece
Journal: Journal of the American College of Cardiology (2001)
Gastric endoscopic submucosal dissection using a detachable assistant robot.
Authors: Sang Hyun Kim, Hyuk Soon Choi, Jae Min Lee, Bora Keum, Byung Gon Kim, Daehie Hong, Yoon Tae Jeen, Hoon Jai Chun
Journal: Journal of Clinical Oncology (2022)

318 Background: Effective traction and counter-traction for visualizing the dissection plane in endoscopic submucosal dissection (ESD) is difficult to be achieved with a conventional endoscope. We developed a robotic assistive traction device for flexible endoscopy that provides multi-directional traction during ESD. We compared its safety and efficiency in ESD between experienced and novice endoscopists. Methods: Robotic ESD was performed by experienced and novice endoscopist groups (n = 2, each). The outcomes included time to complete each ESD step, total procedure time, size of the dissected mucosa, rate of en bloc resection, and major adverse events. Furthermore, incision and dissection speeds were compared between groups. Results: Twenty gastric lesions were resected from nine live pigs. The submucosal incision speed was significantly faster in the expert group than in the novice group (P = 0.002). There was no significant difference in the submucosal dissection speed between the groups (P = 0.365). No complications were reported in either group. Conclusions: When the robot was assisting in the ESD procedure, the dissection speed improved significantly, especially in the novice surgeons. Our robotic device can provide simple, effective, and safe multidirectional traction during ESD.
Evaluation of a Regional Pilot Program to Prevent Mother-Infant HIV Transmission—Thailand, 1998-2000
Journal: JAMA (2001)

Worldwide, approximately 2.2 million women and 600,000 infants are infected with human immunodeficiency virus (HIV) each year. Extended zidovudine prophylaxis and other antiretroviral and obstetric interventions and the avoidance of breast-feeding have reduced dramatically mother-infant HIV transmission in countries with adequate health-care resources. However, in developing countries, where the impact of HIV is greatest, implementation has been limited by the complexity and expense of these interventions. In Thailand, where approximately 15,000 infants are born to HIV-infected women each year, the Ministry of Public Health (MOPH) has collaborated with other organizations to identify simpler and more cost-effective interventions to reduce mother-infant HIV transmission. In 1998, a placebo-controlled clinical trial in Thailand using a simplified zidovudine regimen from 36 weeks' gestation until delivery reduced the risk for mother-infant transmission by 50%. In 1998, MOPH initiated a pilot program to prevent mother-infant HIV transmission in region 7, a rural area in northeastern Thailand with an antenatal HIV prevalence of approximately 1%, to assess program feasibility, effectiveness, and acceptability. This report summarizes an evaluation of the 2-year pilot program, which indicated that acceptance of HIV testing and adherence to zidovudine were high and HIV transmission was reduced. The findings demonstrate the feasibility of implementing programs to prevent mother-infant HIV transmission on a large scale in a developing country.
Rural-urban disparities in mortality from gastrointestinal (GI) cancer.
Authors: Syed Hussaini, Amanda L. Blackford, Arjun Gupta
Journal: Journal of Clinical Oncology (2022)

644 Background: There are notable economic, social, and political challenges to rural healthcare delivery in the US. Patients with GI cancer have high symptom burden and complex needs, challenging healthcare infrastructure. We investigated U.S. rural-urban disparities in age-adjusted mortality rates (AAMRs) from GI cancers. Methods: We utilized the CDC Wonder database to analyze deaths from GI cancer from 1999 to 2019. Per the 2013 US Census classification, we created population categories using the NCHS Urban-Rural Classification Scheme: large metropolitan (population, ≥1 million), small-or-medium-sized metropolitan (50,000-999 999), and rural (&lt;50,000) areas. We calculated AAMRs and stratified results by age, sex, and race/ethnicity. We estimated annual percentage change (APC) in AAMR using a linear regression model of the log-scale with interactions between subgroup and year to examine differential changes over time. Results: We identified 3,020,133 deaths from GI cancers. The overall APC in AAMR was -0.9%, 95%CI, -0.8 to -1.0%. Rural areas noted least improvement in AAMR (APC, -0.6%; 95% CI, -0.4 to -0.6%, interaction p &lt; 0.001) compared to large (APC, -1.2%; 95% CI, -1.1 to -1.3%) and small-or-medium-sized (APC, -0.8%; 95% CI - 0.7 to -0.9%) metropolitans. AAMR in rural areas decreased from 49.2/100,000 in 1999 to 43.8/100,000 in 2019 (p &lt; 0.001; 2019 rural AAMR was highest across all areas) (Table). Across all areas, men had greater AAMRs (p&lt;0.001) and lower reduction in APC (interaction p &lt; 0.001) than women. Non-Hispanic Black individuals (NHBs) had highest AAMRs among all racial/ethnic groups and across all areas (p&lt;0.001). Among those with age≥65 years, NHBs had the highest AAMRs; 367.3/100,000 in 1999 and 266.7/100,000 in 2019, and NHBs living in rural areas had the lowest APC. All racial/ethnic groups saw reductions in AAMRs across all areas. Conclusions: In this national analysis over 2 decades, rural residents with GI cancer experienced greater mortality, and the least improvement in mortality over time. Our findings support ongoing congressional policy to urgently develop infrastructure and improve cancer care access in rural areas. [Table: see text]
Development of a Highly Specific, Selective, and Sensitive Fluorescent Probe for Detection of Mycobacteria in Human Tissues
Authors: Siddhi Gupta, Deepak Kumar Mishra, Mehak Zahoor Khan, Varsha Saini, Devashish Mehta, Sandeep Kumar, Aditya Yadav, Madhurima Mitra, Parul Rani, Mukesh Singh, Chayan Kanti Nandi, Prasenjit Das, Vineet Ahuja, Vinay Kumar Nandicoori, Avinash Bajaj
Journal: Advanced Healthcare Materials (2022)

Abstract Tuberculosis (TB), including extrapulmonary TB, is responsible for more than one million deaths in a year worldwide. Existing methods of mycobacteria detection have poor sensitivity, selectivity, and specificity, especially in human tissues. Herein, the synthesis of a cholic acid‐derived fluorescent probe ( P4 ) that can specifically stain the mycobacterium species is presented. It is shown that P4 probe specifically binds with mycobacterial lipids, trehalose monomycolate, and phosphatidylinositol mannoside 6. P4 probe can detect mycobacteria in polymicrobial planktonic cultures and biofilms with high specificity, selectivity, and sensitivity. Moreover, it can detect a single mycobacterium in the presence of 10 000 other bacilli. Unlike the probes that depend on active mycobacterial enzymes, the membrane‐specific P4 probe can detect mycobacteria even in formalin‐fixed paraffin‐embedded mice and human tissue sections. Therefore, the ability of the P4 probe to detect mycobacteria in different biological milieu makes it a potential candidate for diagnostic and prognostic applications in clinical settings.
The Chicago Health Department—Typhoid Fever.
Authors: Typhoid Fever
Journal: JAMA (1894)

<h3>To the Editor:</h3> —In looking over the Reports of the Chicago Health Department for the months of September, October and November, no mention is made of the number of cases of typhoid fever reported. During these months 210 deaths are given as having been caused by that disease. The number of cases of diphtheria and scarlet fever are reported, but nothing is said about the typhoid fever cases. Is there not an ordinance requiring the notification of the Health Department of every case? Does the Department exercise any sanitary supervision over the cases and their surroundings, or do anything to prevent the spread of the disease? Does it know whether the dejecta of the patients are thoroughly disinfected or not, a matter of vital import to Chicago? How can any care be taken of the cases unless they are reported?