tbuckley/cabot-search huggingface dataset:
Lack of agreement forces NICE to pause publication of ME/CFS guideline
Authors: Gareth Iacobucci
Journal: BMJ (2021)

The National Institute for Health and Care Excellence (NICE) has paused the planned publication of its updated guideline on the diagnosis and management of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) to allow it to deal with concerns raised by professionals ahead of its publication.

In a statement issued on 17 August 2021, the day the guideline was expected to be published, NICE said, “Because of issues raised during the pre-publication period with the final guideline, we need to take time to consider …
Bridging the Divide
Authors: Patrick F. Elliott
Journal: Annals of Internal Medicine (2021)

On Being a DoctorAugust 2021Bridging the DividePatrick F. Elliott, MD, MPH, DTM&HPatrick F. Elliott, MD, MPH, DTM&HSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M21-0818 Audio Reading - “Bridging the Divide” Audio. Virginia L. Hood, MD, a physician from the University of Vermont, reads “Bridging the Divide” by Patrick F. Elliott, MD, MPH, DTM&H Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I went to see Kevin on the oncology ward one afternoon as the wet season was nearing its end. Like many of my patients, he wasn't in his bed. I had been told that Kevin enjoyed being outside in the humid Darwin sun for long periods and that he could be a challenge to track down. Rotating on the consult service for palliative medicine, I can't deny that I felt a little relief upon realizing I might have one less consult that busy afternoon. However, when I spoke to Kevin's nurse, she told me that he was keen to catch ... Author, Article, and Disclosure InformationAffiliations: Corresponding Author: Patrick F. Elliott, MD, MPH, DTM&H, Royal Darwin Hospital, 105 Rocklands Drive, Tiwi, NT 0810, Australia; e-mail, elliott.[email protected]com. PreviousarticleNextarticle Advertisement Audio Reading - “Bridging the Divide” Audio. Virginia L. Hood, MD, a physician from the University of Vermont, reads “Bridging the Divide” by Patrick F. Elliott, MD, MPH, DTM&H Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics August 2021Volume 174, Issue 8Page: 1173-1174 ePublished: 17 August 2021 Issue Published: August 2021 Copyright & PermissionsCopyright © 2021 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
25258 Efficacy and safety of ixekizumab in Chinese patients with moderate-to-severe plaque psoriasis: 12-week results from a phase 3 study
Authors: Wenlong Rui, Xia Li, Jie Zheng, Weili Pan, Min Zheng, Yan Lu, Fuqiu Li, Yangfeng Ding, Jianzhong Zhang, Hongying Li
Journal: Journal of the American Academy of Dermatology (2021)
Nutritional deficiency contributing to refractory erythroderma in hematopoietic cell transplant patients: Distinctive clinical and histopathologic findings
Authors: Marten C G Winge, Kerri E Rieger, Jinah Kim, Wen-Kai Weng, Laura J Johnston, David B Miklos, Thet Su Win, Jenna Strelo, Lisa C Zaba, Silvina B Pugliese, Roberto A Novoa, Bernice Y Kwong
Journal: Journal of the American Academy of Dermatology (2021)
Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice
Authors: Tim Pieters, Sara T’Sas, Stijn Vanhee, André Almeida, Yasmine Driege, Juliette Roels, Wouter Van Loocke, Willem Daneels, Mathijs Baens, Arnaud Marchand, Maaike Van Trimpont, Filip Matthijssens, Julie Morscio, Kelly Lemeire, Béatrice Lintermans, Lindy Reunes, Patrick Chaltin, Fritz Offner, Jo Van Dorpe, Tino Hochepied, Geert Berx, Rudi Beyaert, Jens Staal, Pieter Van Vlierberghe, Steven Goossens
Journal: The Journal of Experimental Medicine (2021)

Mantle cell lymphoma (MCL) is an aggressive B cell lymphoma with poor long-term overall survival. Currently, MCL research and development of potential cures is hampered by the lack of good in vivo models. MCL is characterized by recurrent translocations of CCND1 or CCND2, resulting in overexpression of the cell cycle regulators cyclin D1 or D2, respectively. Here, we show, for the first time, that hematopoiesis-specific activation of cyclin D2 is sufficient to drive murine MCL-like lymphoma development. Furthermore, we demonstrate that cyclin D2 overexpression can synergize with loss of p53 to form aggressive and transplantable MCL-like lymphomas. Strikingly, cyclin D2–driven lymphomas display transcriptional, immunophenotypic, and functional similarities with B1a B cells. These MCL-like lymphomas have B1a-specific B cell receptors (BCRs), show elevated BCR and NF-κB pathway activation, and display increased MALT1 protease activity. Finally, we provide preclinical evidence that inhibition of MALT1 protease activity, which is essential for the development of early life–derived B1a cells, can be an effective therapeutic strategy to treat MCL.
Association Between Endoscopist Specialty and Colonoscopy Quality: A Systematic Review and Meta-analysis
Authors: Matthew Mazurek, Alistair Murray, Steven J. Heitman, Yibing Ruan, Stavros A. Antoniou, Devon Boyne, Sanjay Murthy, Nancy N. Baxter, Indraneel Datta, Risa Shorr, Christopher Ma, Mark G. Swain, Robert J. Hilsden, Darren R. Brenner, Nauzer Forbes
Journal: Clinical Gastroenterology and Hepatology (2021)
Association of neighbourhood socioeconomic trajectories with preterm birth and small-for-gestational-age in the Netherlands: a nationwide population-based study
Authors: Lizbeth Burgos Ochoa, Loes CM Bertens, Pilar Garcia-Gomez, Tom Van Ourti, Eric AP Steegers, Jasper V Been
Journal: The Lancet Regional Health - Europe (2021)

Adverse birth outcomes have serious health consequences, not only during infancy but throughout the entire life course. Most evidence linking neighbourhood socioeconomic status (SES) to birth outcomes is based on cross-sectional SES measures, which do not reflect neighbourhoods' dynamic nature. We investigated the association between neighbourhood SES trajectories and adverse birth outcomes, i.e. preterm birth and being small-for-gestational-age (SGA), for births occurring in the Netherlands between 2003 and 2017.
Proneural genes define ground-state rules to regulate neurogenic patterning and cortical folding
Authors: Sisu Han, Satoshi Okawa, Grey Atteridge Wilkinson, Hussein Ghazale, Lata Adnani, Rajiv Dixit, Ligia Tavares, Imrul Faisal, Matthew J. Brooks, Veronique Cortay, Dawn Zinyk, Adam Sivitilli, Saiqun Li, Faizan Malik, Yaroslav Ilnytskyy, Vladimir Espinosa Angarica, Jinghua Gao, Vorapin Chinchalongporn, Ana-Maria Oproescu, Lakshmy Vasan, Yacine Touahri, Luke Ajay David, Eko Raharjo, Jung-Woong Kim, Wei Wu, Waleed Rahmani, Jennifer Ai-wen Chan, Igor Kovalchuk, Liliana Attisano, Deborah Kurrasch, Colette Dehay, Anand Swaroop, Diogo S. Castro, Jeff Biernaskie, Antonio del Sol, Carol Schuurmans
Journal: Neuron (2021)
Reenvisioning End-of-Life Care Quality Measurement for Adolescents and Young Adults With Cancer—Novel Patient-Centered Indicators and Approaches
Authors: Prasanna Ananth
Journal: JAMA Network Open (2021)

Jennifer W. Mack, MD, MPH; Lauren Fisher, MPH; Larry Kushi, ScD; Chun R. Chao, PhD; Brenda Vega, BA; Gilda Rodrigues, BA; Isabel Josephs, BS; Katharine E. Brock, MD, MS; Susan Buchanan, MS, PA-C; Mallory Casperson, MS; Robert M. Cooper, MD; Karen M. Fasciano, PsyD; Tatjana Kolevska, MD; Joshua R. Lakin, MD; Anna Lefebvre, NP; Corey M. Schwartz, MD; Dov M. Shalman, MD; Catherine B. Wall, NP; Lori Wiener, PhD; Andrea Altschuler, PhD
P-262 Staining plasma with lipophilic dye followed by size-exclusion chromatography, immune-capturing and on-bead flow cytometry is a highly sensitive approach to quantifying colorectal cancer derived extracellular nanovesicles
Authors: N. Nikiforova, I. Nazarova, M. Slusarenko, E. Sidina, A. Malek
Journal: Annals of Oncology (2021)
26945 Purpuric pressure ulcers in hospitalized patients with COVID-19: A case series
Authors: Sidharth Chand, Renajd Rrapi, Jennifer Lo, Sarah Song, Colleen Gabel, Niyati Desai, Mai Hoang, Daniela Kroshinsky
Journal: Journal of the American Academy of Dermatology (2021)

Background: Purpuric lesions may represent the proposed coagulopathy and microvascular injury of COVID-19. Pressure ulcers are a concerning comorbidity for patients with prolonged hospitalizations due to impaired perfusion and reduced mobility. This study reports a novel cutaneous manifestation associated with COVID-19: purpuric pressure ulcers. Methods: Single-center, retrospective review of 11 laboratory-confirmed COVID-19 patients consulted for evaluation by dermatology for purpuric pressure necrosis from March through May 2020. Results: All patients were critically ill with admission to the intensive care unit, and three (27.3%) died during hospitalization. The mean time to onset of skin lesions was 10 days (SD 5.4) from admission. Patients were noted to have purpura at dependent sites, often with geometric borders and sometimes with associated bullae, which typically progressed to central ulceration with eschar. Purpuric pressure injuries were observed most frequently at the buttocks (63.6%). Average D-dimer and fibrinogen levels were elevated, and prothrombin time was mildly elevated, while partial thromboplastin time and platelet counts remained within normal range. Buttock purpura skin biopsies obtained from three patients showed epidermal and eccrine gland necrosis and fibrin thrombi within superficial, but not deep, dermal blood vessels supportive of pressure injury. SARS-CoV-2 RNA in-situ hybridization performed on all three skin pressure injury biopsies was negative. Conclusion: These skin findings appear to be distinct from and benign in comparison to the systemic thrombotic vasculopathy associated with COVID-19. Purpuric pressure necrosis without thrombotic vasculopathy can be seen with COVID-19 hospitalization.
ワルファリンと比べたエドキサバンの有効性と安全性に及ぼすアジアにおける地域差の影響:ENGAGE AF-TIMI48からの洞察
Authors: J Shimada Yuichi, Yamashita Takeshi, Koretsune Yukihiro, Kimura Tetsuya, Abe Kenji, Sasaki Shunichi, Mercuri Michele, T Ruff Christian., P Giugliano Robert.
Journal: Circulation (2015)
A boy with annular erythema on the nose
Authors: Ya Bin Zhou, Lin Ma, Yuan Yuan Xiao
Journal: BMJ (2021)

A 4 year old boy presented with annular erythema on his nose. The lesion had begun as a small itchy macule seven days earlier. Initially, discoid eczema was diagnosed and he was treated with hydrocortisone butyrate ointment for three days. Although the pruritus improved, the skin rash became more extensive. The patient had no history of preceding injury or insect bite. The household had a cat. On physical examination, an annular erythematous lesion (1 cm ×1 cm) without scaling was observed on the boy’s nose (fig 1).



Fig 1 
1 cm × 1 cm infiltrated annular erythema without scaling on …
Targeted Intraoperative Molecular Imaging for Localizing Nonpalpable Tumors and Quantifying Resection Margin Distances
Authors: Gregory T. Kennedy, Feredun S. Azari, Elizabeth Bernstein, Isvita Marfatia, Azra Din, John C. Kucharczuk, Philip S. Low, Sunil Singhal
Journal: JAMA Surgery (2021)

Complete (R0) resection is the dominant prognostic factor for survival across solid tumor types. Achieving adequate tumor clearance with appropriate margins is particularly difficult in nonpalpable tumors or in situ disease. Previous methods to address this problem have proven time consumptive, impractical, or ineffective.To assess the capability of intraoperative molecular imaging (IMI), a novel technology using a fluorescent tracer targeted to malignant cells, to localize visually occult, nonpalpable tumors and quantify margin distances during resection.This nonrandomized open-label trial of IMI using a folate receptor-targeted fluorescent tracer enrolled patients between May 2017 and June 2020 at a single referral center. Eligible patients included those with a small (T1) lung lesion suspicious for malignant neoplasms and with radiographic features suggestive of a nonpalpable lesion.Patients were preoperatively infused with a folate receptor-targeted near-infrared tracer. Intraoperatively, surgeons used thoracoscopic visualization and palpation to identify lesions. IMI was performed to detect the lesion in situ, and lesions were imaged ex vivo. Margins were assessed by IMI before comparison with those reported on final histopathologic analysis.The main outcomes were whether IMI could (1) localize nonpalpable lung lesions in situ and (2) quantify margin distance with comparison with final pathology as the criterion standard. Patient demographic information and lesion characteristics were prospectively recorded.Of 40 patients, 26 (65%) were female, and the median (interquartile range) age was 66.5 (62-72) years. Conventional surgical methods localized 22 of 40 lesions (55%), while IMI localized 36 of 40 (90%). Of 18 nonpalpable lesions, 15 (83.3%) were identified by IMI. Both palpable and nonpalpable lesions demonstrated mean signal-to-background ratio more than 2. An IMI margin was able to be calculated for 39 of 40 patients (95%). IMI margins were nearly identical to margins reported on final pathology (R2 = 0.9593), with median (interquartile range) difference of 1.3 (0.7-2.0) mm. IMI detected 2 margins in nonpalpable tumors that were clinically unacceptable and would have had a high probability of recurrence.To our knowledge, this study presents the first clinical use of IMI for nonpalpable tumors and provides proof of principle for the utility of IMI across the field of surgical oncology in identifying occult disease and tumor-positive margins.
Treatment with ROS detoxifying gold quantum clusters alleviates the functional decline in a mouse model of Friedreich ataxia
Authors: Chiara Villa, Mariella Legato, Alessandro Umbach, Chiara Riganti, Rebecca Jones, Beatrice Martini, Marina Boido, Claudio Medana, Irene Facchinetti, Dario Barni, Milena Pinto, Tania Arguello, Marzia Belicchi, Gigliola Fagiolari, Carla Liaci, Maurizio Moggio, Riccardo Ruffo, Carlos T. Moraes, Angelo Monguzzi, Giorgio R. Merlo, Yvan Torrente
Journal: Science Translational Medicine (2021)

Gold quantum clusters are therapeutic in preclinical models of Friedreich ataxia.
Monitoring SARS-CoV-2 variants alterations in Nice neighborhoods by wastewater nanopore sequencing
Authors: Géraldine Rios, Caroline Lacoux, Vianney Leclercq, Anna Diamant, Kévin Lebrigand, Adèle Lazuka, Emmanuel Soyeux, Sébastien Lacroix, Julien Fassy, Aurélie Couesnon, Richard Thiery, Bernard Mari, Christian Pradier, Rainer Waldmann, Pascal Barbry
Journal: The Lancet Regional Health - Europe (2021)

Wastewater surveillance was proposed as an epidemiological tool to define the prevalence and evolution of the SARS-CoV-2 epidemics. However, most implemented SARS-CoV-2 wastewater surveillance projects were based on qPCR measurement of virus titers and did not address the mutational spectrum of SARS-CoV-2 circulating in the population.We have implemented a nanopore RNA sequencing monitoring system in the city of Nice (France, 550,000 inhabitants). Between October 2020 and March 2021, we monthly analyzed the SARS-CoV-2 variants in 113 wastewater samples collected in the main wastewater treatment plant and 20 neighborhoods.We initially detected the lineages predominant in Europe at the end of 2020 (B.1.160, B.1.177, B.1.367, B.1.474, and B.1.221). In January, a localized emergence of a variant (Spike:A522S) of the B.1.1.7 lineage occurred in one neighborhood. It rapidly spread and became dominant all over the city. Other variants of concern (B.1.351, P.1) were also detected in some neighborhoods, but at low frequency. Comparison with individual clinical samples collected during the same week showed that wastewater sequencing correctly identified the same lineages as those found in COVID-19 patients.Wastewater sequencing allowed to document the diversity of SARS-CoV-2 sequences within the different neighborhoods of the city of Nice. Our results illustrate how sequencing of sewage samples can be used to track pathogen sequence diversity in the current pandemics and in future infectious disease outbreaks.For the French translation of the abstract see Supplementary Materials section.
In-hospital use of ACE inhibitors/angiotensin receptor blockers associates with COVID-19 outcomes in African American patients
Authors: Shilong Li, Rangaprasad Sarangarajan, Tomi Jun, Yu-Han Kao, Zichen Wang, Ke Hao, Emilio Schadt, Michael A. Kiebish, Elder Granger, Niven R. Narain, Rong Chen, Eric E. Schadt, Li Li
Journal: Journal of Clinical Investigation (2021)

BACKGROUND. The angiotensin-converting enzyme (ACE) D allele is more prevalent among African Americans compared with other races and ethnicities and has previously been associated with severe coronavirus disease 2019 (COVID-19) pathogenesis through excessive ACE1 activity. ACE inhibitors/angiotensin receptor blockers (ACE-I/ARB) may counteract this mechanism, but their association with COVID-19 outcomes has not been specifically tested in the African American population.
27174 Health-related quality of life (HRQoL) in patients with hidradenitis suppurativa: A single center analysis
Authors: David A. Castillo Molina, Paula A. Chacón Jaramillo, Marcela Duran-Torres, Jesus D. Fierro Lozada, Daniela M. Molina Dorado, Maria D. Polania Tovar, Maria J. Carroll-Patiño, Zamira P. Vargas Caycedo, Nelson José Alvis-Zakzuk
Journal: Journal of the American Academy of Dermatology (2021)
Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome: fevers, myalgia, arthralgia, auricular chondritis, and erythema nodosum
Authors: Natasha Dehghan, Krista M Marcon, Tony Sedlic, David B Beck, Jan P Dutz, Luke Y C Chen
Journal: The Lancet (2021)
Programmed Death-Ligand 1 Tumor Proportion Score and Overall Survival From First-Line Pembrolizumab in Patients With Nonsquamous Versus Squamous NSCLC
Authors: Deborah B. Doroshow, Wei Wei, Swati Gupta, Jon Zugazagoitia, Charles Robbins, Blythe Adamson, David L. Rimm
Journal: Journal of Thoracic Oncology (2021)
Treatment Escalation vs Immediate Initiation of Highly Effective Treatment for Patients With Relapsing-Remitting Multiple Sclerosis
Authors: Tim Spelman, Melinda Magyari, Fredrik Piehl, Anders Svenningsson, Peter Vestergaard Rasmussen, Matthias Kant, Finn Sellebjerg, Hanna Joensen, Jan Hillert, Jan Lycke
Journal: JAMA Neurology (2021)

Treatment strategies for relapsing-remitting multiple sclerosis (RRMS) vary markedly between Denmark and Sweden. The difference in the association of these national strategies with clinical outcomes is unknown.To investigate the association of national differences in disease-modifying treatment (DMT) strategies for RRMS with disability outcomes.This cohort study used data on 4861 patients from the Danish and Swedish national multiple sclerosis (MS) registries from the date of index DMT initiation (between January 1, 2013, and December 31, 2016) until the last recorded visit at time of data extraction (October 2, 2019).All MS-specific DMTs initiated during the observation period were included in the analysis.The primary study outcome was time to 24-week confirmed disability worsening. Secondary outcomes were 24-week confirmed disability improvement, milestone Expanded Disability Status Scale scores of 3 and 4, annualized relapse rate, time to first relapse, and treatment switching. Data were analyzed using inverse probability of treatment weighting-based models using a propensity score to weight and correct the comparison for the imbalance of confounders observed at baseline between the 2 countries.A total of 2700 patients from the Swedish MS registry (1867 women [69.2%]; mean [SD] age, 36.1 [9.5] years) and 2161 patients from the Danish MS registry (1472 women [68.1%]; mean [SD] age, 37.3 [9.4 years]) started a first DMT between 2013 and 2016, were included in the analysis, and were observed for a mean (SD) of 4.1 (1.5) years. A total of 1994 Danish patients (92.3%) initiated a low to moderately effective DMT (teriflunomide, 907 [42.0%]) and 165 (7.6%) initiated a highly effective DMT, whereas a total of 1769 Swedish patients (65.5%) initiated a low to moderately effective DMT (teriflunomide, 64 [2.4%]) and 931 (34.5%) initiated a highly effective DMT. The Swedish treatment strategy was associated with a 29% reduction in the rate of postbaseline 24-week confirmed disability worsening relative to the Danish treatment strategy (hazard ratio, 0.71; 95% CI, 0.57-0.90; P = .004). The Swedish treatment strategy was also associated with a 24% reduction in the rate of reaching an expanded disability status scale score of 3 (hazard ratio, 0.76; 95% CI, 0.60-0.97; P = .03) and a 25% reduction in the rate of reaching an expanded disability status scale score of 4 (hazard ratio, 0.75; 95% CI, 0.61-0.96; P = .01) relative to Danish patients.The findings of this study suggest that there is an association between differences in treatment strategies for RRMS and disability outcomes at a national level. Escalation of treatment efficacy was inferior to using more efficacious DMT as initial treatment.
NPAS4 regulates the transcriptional response of the suprachiasmatic nucleus to light and circadian behavior
Authors: Pin Xu, Stefano Berto, Ashwinikumar Kulkarni, Byeongha Jeong, Chryshanthi Joseph, Kimberly H. Cox, Michael E. Greenberg, Tae-Kyung Kim, Genevieve Konopka, Joseph S. Takahashi
Journal: Neuron (2021)
Placental endocrine function shapes cerebellar development and social behavior
Authors: Claire-Marie Vacher, Helene Lacaille, Jiaqi J. O’Reilly, Jacquelyn Salzbank, Dana Bakalar, Sonia Sebaoui, Philippe Liere, Cheryl Clarkson-Paredes, Toru Sasaki, Aaron Sathyanesan, Panagiotis Kratimenos, Jacob Ellegood, Jason P. Lerch, Yuka Imamura, Anastas Popratiloff, Kazue Hashimoto-Torii, Vittorio Gallo, Michael Schumacher, Anna A. Penn
Journal: Nature Neuroscience (2021)

Compromised placental function or premature loss has been linked to diverse neurodevelopmental disorders. Here we show that placenta allopregnanolone (ALLO), a progesterone-derived GABA-A receptor (GABAAR) modulator, reduction alters neurodevelopment in a sex-linked manner. A new conditional mouse model, in which the gene encoding ALLO's synthetic enzyme (akr1c14) is specifically deleted in trophoblasts, directly demonstrated that placental ALLO insufficiency led to cerebellar white matter abnormalities that correlated with autistic-like behavior only in male offspring. A single injection of ALLO or muscimol, a GABAAR agonist, during late gestation abolished these alterations. Comparison of male and female human preterm infant cerebellum also showed sex-linked myelination marker alteration, suggesting similarities between mouse placental ALLO insufficiency and human preterm brain development. This study reveals a new role for a placental hormone in shaping brain regions and behaviors in a sex-linked manner. Placental hormone replacement might offer novel therapeutic opportunities to prevent later neurobehavioral disorders.