tbuckley/cabot-search huggingface dataset:
Sharing Clinical Notes
Authors: Charlotte Blease, I. Glenn Cohen, Sharona Hoffman
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Right Ventricular-Pulmonary Arterial Coupling and Afterload Reserve in Patients Undergoing Transcatheter Tricuspid Valve Repair
Authors: Michael I. Brener, Philipp Lurz, Jörg Hausleiter, Josep Rodés-Cabau, Neil Fam, Susheel K. Kodali, Karl-Philipp Rommel, Guillem Muntané-Carol, Mara Gavazzoni, Tamim M. Nazif, Alberto Pozzoli, Hannes Alessandrini, Azeem Latib, Luigi Biasco, Daniel Braun, Eric Brochet, Paolo Denti, Edith Lubos, Sebastian Ludwig, Daniel Kalbacher, Rodrigo Estevez-Loureiro, Kim A. Connelly, Christian Frerker, Edwin C. Ho, Jean-Michel Juliard, Claudia Harr, Vanessa Monivas, Georg Nickenig, Giovanni Pedrazzini, François Philippon, Fabien Praz, Rishi Puri, Joachim Schofer, Horst Sievert, Gilbert H.L. Tang, Martin Andreas, Holger Thiele, Matthias Unterhuber, Dominique Himbert, Marina Ureña Alcázar, Ralph Stephan Von Bardeleben, Stephan Windecker, Mirjam G. Wild, Francesco Maisano, Martin B. Leon, Maurizio Taramasso, Rebecca T. Hahn
Journal: Journal of the American College of Cardiology (2022)
The impact of pictorial health warnings on purchases of sugary drinks for children: A randomized controlled trial
Authors: Marissa G. Hall, Anna H. Grummon, Isabella C. A. Higgins, Allison J. Lazard, Carmen E. Prestemon, Mirian I. Avendaño-Galdamez, Lindsey Smith Taillie
Journal: PLoS Medicine (2022)

Background Pictorial warnings on tobacco products are promising for motivating behavior change, but few studies have examined pictorial warnings for sugary drinks, especially in naturalistic environments. This study aimed to examine the impact of pictorial warnings on parents’ purchases of sugary drinks for their children in a naturalistic store laboratory. Methods and findings Parents of children ages 2 to 12 ( n = 325, 25% identifying as Black, 20% Hispanic) completed a shopping task in a naturalistic store laboratory in North Carolina. Participants were randomly assigned to a pictorial warnings arm (sugary drinks displayed pictorial health warnings about type 2 diabetes and heart damage) or a control arm (sugary drinks displayed a barcode label). Parents selected 1 beverage and 1 snack for their child, as well as 1 household good; one of these items was selected for them to purchase and take home. The primary outcome was whether parents purchased a sugary drink for their child. Secondary outcomes included reactions to the trial labels, attitudes toward sugary drinks, and intentions to serve their child sugary drinks. Pictorial warnings led to a 17-percentage point reduction in purchases of sugary drinks (95% CI for reduction: 7% to 27%), with 45% of parents in the control arm buying a sugary drink for their child compared to 28% in the pictorial warning arm ( p = 0.002). The impact of pictorial warnings on purchases did not differ by any of the 13 participant characteristics examined (e.g., race/ethnicity, income, education, and age of child). Pictorial warnings also led to lower calories (kcal), purchased from sugary drinks (82 kcal in the control arm versus 52 kcal in the pictorial warnings arm, p = 0.003). Moreover, pictorial warnings led to lower intentions to serve sugary drinks to their child, feeling more in control of healthy eating decisions, greater thinking about the harms of sugary drinks, stronger negative emotional reactions, greater anticipated social interactions, lower perceived healthfulness of sugary drinks for their child, and greater injunctive norms to limit sugary drinks for their child (all p &lt; 0.05). There was no evidence of difference between trial arms on noticing of the labels, appeal of sugary drinks, perceived amount of added sugar in sugary drinks, risk perceptions, or perceived tastiness of sugary drinks (all p &gt; 0.05). Conclusions Pictorial warnings reduced parents’ purchases of sugary drinks for their children in this naturalistic trial. Warnings on sugary drinks are a promising policy approach to reduce sugary drink purchasing in the US. Trial registration The trial design, measures, power calculation, and analytic plan were registered before data collection at www.clinicaltrials.gov NCT04223687 .
Recommended musculoskeletal and sports ultrasound terminology: a Delphi-based consensus statement
Authors: Mederic M Hall, Georgina M Allen, Sandra Allison, Joseph Craig, Joseph P DeAngelis, Patricia B Delzell, Jonathan T Finnoff, Rachel M Frank, Atul Gupta, Douglas Hoffman, Jon A Jacobson, Samer Narouze, Levon Nazarian, Kentaro Onishi, Jeremiah Wayne Ray, Luca Maria Sconfienza, Jay Smith, Alberto Tagliafico
Journal: British Journal of Sports Medicine (2022)

The current lack of agreement regarding standardised terminology in musculoskeletal and sports ultrasound presents challenges in education, clinical practice and research. This consensus was developed to provide a reference to improve clarity and consistency in communication. A multidisciplinary expert panel was convened consisting of 18 members representing multiple specialty societies identified as key stakeholders in musculoskeletal and sports ultrasound. A Delphi process was used to reach consensus, which was defined as group level agreement of >80%. Content was organised into seven general topics including: (1) general definitions, (2) equipment and transducer manipulation, (3) anatomical and descriptive terminology, (4) pathology, (5) procedural terminology, (6) image labelling and (7) documentation. Terms and definitions which reached consensus agreement are presented herein. The historic use of multiple similar terms in the absence of precise definitions has led to confusion when conveying information between colleagues, patients and third-party payers. This multidisciplinary expert consensus addresses multiple areas of variability in diagnostic ultrasound imaging and ultrasound-guided procedures related to musculoskeletal and sports medicine.
Period-Dependent Survival Benefit of Percutaneous Microwave Ablation for Hepatocellular Carcinoma: A 12-Year Real-World, Multicentric Experience
Authors: Jie Yu, Zhi-Gang Cheng, Zhi-Yu Han, Fang-Yi Liu, Rong-Qin Zheng, Wen Cheng, Qiang Wei, Song-Yuan Yu, Qin-ying Li, Guang-zhi He, Yan-chun Luo, Xiao-Ling Yu, Ping Liang
Journal: Liver Cancer (2022)

Although microwave ablation (MWA) is a promising technique for hepatocellular carcinoma (HCC) treatment, its 10-year efficacy is unknown.The objective of the study was to assess whether the advances in MWA for HCC translated into a real-world survival benefit.This retrospective study included 2,354 patients with Barcelona Clinic Liver Cancer (BCLC) stage 0 to B from 5 hospitals, with at least 2 years of follow-up for all the patients. Recurrence and survival were analyzed using the Kaplan-Meier method with time-period stratification.A total of 5,326 HCCs (mean diameter, 2.9 cm ± 1.2) underwent 4,051 sessions of MWA with a median follow-up of 61.3 (0.6-169.5 range) months during 3 periods (2007-2010, 2011-2014, and 2015-2018). Technical success was achieved in 5,194 (97.5%) tumors with significant improvement over time, especially for >3.0-cm HCC (p < 0.001). Local tumor progression (LTP) showed no period-dependent advance, with >3.0-cm HCC and perivascular location being the risk factors for LTP. The median intrahepatic metastasis time was 27.6 (95% confidence interval [CI]: 25.2-28.8) months, with 5- and 10-year occurrence rates of 68.8% and 79.4%, respectively. The 5- and 10-year overall survivals were 63.9% and 41.1%, respectively, and BCLC stage 0, A, and all B patients showed an observable survival improvement over time (p < 0.001). The median disease-free survival time increased from 19.4 (95% CI: 16.5-22.6) months in 2007-2010 to 28.1 (95% CI: 25.9-32.3) months in 2015-2018. The improved survival for early recurrent (≤2 years) patients was period-dependent, as verified by Cox regression analyses. The major complications rate per procedure was 3.0% (122/4,051).These real-world data show that MWA provided an upward trend in survival for HCC patients with BCLC stage 0-B over a 12-year follow-up period. An encouraging clear survival benefit in early recurrent patients was also observed.
Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study
Authors: Agata Wesolowska-Andersen, Caroline A. Brorsson, Roberto Bizzotto, Andrea Mari, Andrea Tura, Robert Koivula, Anubha Mahajan, Ana Vinuela, Juan Fernandez Tajes, Sapna Sharma, Mark Haid, Cornelia Prehn, Anna Artati, Mun-Gwan Hong, Petra B. Musholt, Azra Kurbasic, Federico De Masi, Kostas Tsirigos, Helle Krogh Pedersen, Valborg Gudmundsdottir, Cecilia Engel Thomas, Karina Banasik, Chrisopher Jennison, Angus Jones, Gwen Kennedy, Jimmy Bell, Louise Thomas, Gary Frost, Henrik Thomsen, Kristine Allin, Tue Haldor Hansen, Henrik Vestergaard, Torben Hansen, Femke Rutters, Petra Elders, Leen t’Hart, Amelie Bonnefond, Mickaël Canouil, Soren Brage, Tarja Kokkola, Alison Heggie, Donna McEvoy, Andrew Hattersley, Timothy McDonald, Harriet Teare, Martin Ridderstrale, Mark Walker, Ian Forgie, Giuseppe N. Giordano, Philippe Froguel, Imre Pavo, Hartmut Ruetten, Oluf Pedersen, Emmanouil Dermitzakis, Paul W. Franks, Jochen M. Schwenk, Jerzy Adamski, Ewan Pearson, Mark I. McCarthy, Søren Brunak
Journal: Cell Reports Medicine (2022)
BUCHAREST
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
25324 The in-hospital burden of dermatomyositis on patients with acute myocardial infarction: A nationwide cross-sectional analysis from 2004 to 2015
Authors: Alvaro J. Ramos-Rodriguez, Karina J. Cancel-Artau, Alejandro Lemor, Osward Y. Carrasquillo, Mario Lozano-Franco, Marely Santiago-Vazquez, Julian Barrera-Llaurador, Rafael F. Martin-Garcia
Journal: Journal of the American Academy of Dermatology (2021)
Cytoskeleton Regulation of Ion Channels
Authors: Ying Fu, Shaohua Xiao, TingTing Hong, Robin M. Shaw
Journal: Circulation (2015)

C ardiac arrhythmia is one of the leading causes of sudden death in developed countries, and results from abnormal cardiac electric activity.Regular beat-to-beat cardiac excitability requires the coordinated activity of membranebound ionophoric proteins that are channels and transporters.Aberrant currents can result from either changes in the gating properties of ionophores or altered trafficking to their appropriate membrane subdomain.Mutations in the genes of ionophoric proteins result in inherited human arrhythmogenic syndromes.3][4][5] In addition, mutations in the proteins that make up the trafficking apparatus, namely the cytoskeletal and associated proteins, can also result in arrhythmia disorders.
Exercise prehabilitation during neoadjuvant chemotherapy may enhance tumour regression in oesophageal cancer: results from a prospective non-randomised trial
Authors: Janine Zylstra, Greg P Whyte, Kerri Beckmann, James Pate, Aida Santaolalla, Louise Gervais-Andre, Beth Russell, Nick Maisey, Justin Waters, Gemma Tham, Jesper Lagergren, Michael Green, Mark Kelly, Cara Baker, Mieke Van Hemelrijck, Vicky Goh, James Gossage, Mike Browning, Andrew Davies
Journal: British Journal of Sports Medicine (2022)

There is increasing evidence for the use of exercise in cancer patients and data supporting enhanced tumour volume reduction following chemotherapy in animal models. To date, there is no reported histopathological evidence of a similar oncological benefit in oesophageal cancer.A prospective non-randomised trial compared a structured prehabilitation exercise intervention during neoadjuvant chemotherapy and surgery versus conventional best-practice for oesophageal cancer patients. Biochemical and body composition analyses were performed at multiple time points. Outcome measures included radiological and pathological markers of disease regression. Logistic regression calculated ORs with 95% CI for the likelihood of pathological response adjusting for chemotherapy regimen and chemotherapy delivery.Comparison of the Intervention (n=21) and Control (n=19) groups indicated the Intervention group had higher rates of tumour regression (Mandard TRG 1-3 Intervention n=15/20 (75%) vs Control n=7/19 (36.8%) p=0.025) including adjusted analyses (OR 6.57; 95% CI 1.52 to 28.30). Combined tumour and node downstaging (Intervention n=9 (42.9%) vs Control n=3 (15.8%) p=0.089) and Fat Free Mass index were also improved (Intervention 17.8 vs 18.7 kg/m2; Control 16.3 vs 14.7 kg/m2, p=0.026). Differences in markers of immunity (CD-3 and CD-8) and inflammation (IL-6, VEGF, INF-y, TNFa, MCP-1 and EGF) were observed.The results suggest improved tumour regression and downstaging in the exercise intervention group and should prompt larger studies on this topic.NCT03626610.
THE ROLE OF CLAVULANIC ACID IN IMMEDIATE ALERGIC REACTIONS TO BETA-LACTAMS
Authors: Natalia Blanca-López, Ana Maria Prieto-Moreno Pfeifer, Isabel Torres Rojas, Diana Pérez-Alzate, M Luisa Somoza, Elisa Haroun-Diaz, Maria Vazquez de La Torre, Paula Lopez, Maria D. Cervera Garcia, Carlos Alberto Blanco Mota, Francisco Javier Ruano, Miguel Blanca
Journal: Journal of Allergy and Clinical Immunology (2022)
Down, but Not Out: A Role for SMARCB1 in Synovial Sarcoma
Authors: Matthew B. Maxwell, Diana C. Hargreaves
Journal: Cancer Discovery (2021)

Abstract Summary: Reduced protein expression of the BAF complex (also known as SWI/SNF) tumor suppressor SMARCB1 is frequently observed in human synovial sarcoma, a soft-tissue malignancy driven by the oncogenic SS18–SSX fusion, which competes with wild-type SS18 for BAF complex incorporation. In this issue of Cancer Discovery, Li and Mulvihill reveal that low-expressed SMARCB1 has a functional role in synovial sarcomagenesis in mouse models expressing the SS18–SSX2 fusion and present evidence that SMARCB1 reduction in synovial sarcoma is due to wholesale degradation of canonical BAF complexes. See related article by Li et al., p. 2620.
The Cover
Authors: M. Therese Southgate
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Brain Injury Awareness Month — March 2019
Journal: MMWR Morbidity and Mortality Weekly Report (2019)

Brain Injury Awareness Month, observed each March, was established 3 decades ago to educate the public about the incidence of brain injury and the needs of persons with brain injuries and their families (1). Caused by a bump, blow, or jolt to the head, or penetrating head injury, a traumatic brain injury (TBI) can lead to short- or long-term changes affecting thinking, sensation, language, or emotion.
Management and prevention of soft tissue complications in implant dentistry
Authors: Daniel S. Thoma, Alfonso Gil, Christoph H. F. Hämmerle, Ronald E. Jung
Journal: Periodontology 2000 (2022)

The management and prevention of soft tissue complications is of key importance in modern implant dentistry and influences biologic and esthetic outcomes. The assessment of the soft tissue conditions from a quantitative and qualitative perspective should, therefore, be part of the overall treatment plan. Such an assessment dictates a potential indication as well as an ideal time point for additional soft tissue management. A proper risk assessment and management of the soft tissues at the planned implant site are of key importance prior to any implant-related surgery. Cases with peri-implant soft tissue complications generally involve: (a) a lack of attached and keratinized mucosa; (b) insufficient volume; (c) development of mucosal dehiscences; or (d) a combination of (a), (b), and (c). In case of soft tissue deficiencies, these should be addressed as early as possible to increase the predictability of the surgical interventions. This article reviews the main causes for peri-implant soft tissue complications and presents different therapeutic options for the management of various clinical scenarios.
"Prosecution of a Chemist:" A Correction
Journal: BMJ (1893)

the commissioners are satisfied as to the correctness of the figures pro- duced, they will straightway adjust the assessment.Further, if on the preparation of the accounts the appellant finds that he has not realised the profits in 1892 upon which he was charged, before the result of the year's trading was ascertained, it is open to him to claim and obtain repayment of tax overpaid.
Errata
Journal: BMJ (1863)

scured the suin before the ravages of the inifluenza of 1782, end hle sup)poses " that the nmaterial wviiehl tlhuis rendere(d thie air uinwholesomiie an(l muddy, probably cause(l the epidemnic catarrh whiclh prevailed in that year."Somiie sensible people in this country lhave, more- over, told rue, that the influenza of 184:3 was in like manner uslhere(d in by continuous dark and noisome fogs.Be tlis as it may, there is, in 'my opinion, no doubt that this ouir last epidemical influet,za vas in somiie way or other occasioned by the aforesaid dense an(l offensive fog,; and it was, moreover, very rernark- able, thiat tle smell of this fog, being quiite iunilike coiiimon fo(gs, was that of a Iigltly concenitrated ozonic, gas, whiclh imnmdiately irritate(d the mucous mem-lbrane ot the Itings, and most likely also the otlher mucous m-lem- branes of thte bodly.SOUTHE 1 AS FERN BRANCH.
FCERIA Single Nucleotide Polymorphisms Associated with Nonsteroidal Anti-inflammatory Drug-induced Acute Urticaria/Angioedema
Authors: Raquel Jurado-Escobar, Inmaculada Dona, Almudena Testera Montes, Joan Bartra, Natalia Perez Sanchez, Jose Laguna, Anyith Cruz-Amaya, Rocio Saenz de Santamaria, Rafael Nuñez, Maria Salas, Marina Labella, Maria Torres, Jose Cornejo-Garcia
Journal: Journal of Allergy and Clinical Immunology (2022)

Nonsteroidal anti-inflammatory drugs (NSAIDs) are probably the main causes of drug hypersensitivity reactions, with NSAIDs-induced acute urticaria/angioedema (NIUA) being the most frequent clinical phenotype. The underlying mechanism of NSAID-hypersensitivity has been linked to COX-1 inhibition and the subsequent increase in cysteinyl-leukotrienes release from arachidonic acid, triggering a reaction in susceptible individuals. Different studies have highlighted the association between NIUA and the atopic status, especially with Dermatophagoides pteronyssinus (DP) sensitisation. As the immunoglobulin epsilon receptor plays a substantial role in allergic diseases and atopy, and considering that both NSAID-hypersensitivity and atopic diseases development appear to be influenced by genetic factors, we have analysed for the first time the genetic variation in the alpha unit of the immunoglobulin epsilon receptor (FCER1A) in patients with NIUA. Seven tag single nucleotide polymorphisms (tSNPs) were evaluated in 269 NIUA patients and 300 healthy sex- and age- matched controls. tSNPs were selected from European populations using 1000 Genomes Project available data and genotyped with the iPlex Sequenom MassArray technology. A statistically significant association was found between the rs2494250 FCER1A variant and NIUA risk. In addition, this downstream polymorphism was associated with DP sensitisation. Our results suggest a role for FCER1A polymorphisms in the link between NIUA and atopy, probably by affecting post-trancriptional control. Nevertheless, further studies are required to replicate our findings and to elucidate the underlying mechanism at the molecular level. In addition, the potential participation of FCER1A variation in other NSAID-hypersensitivity phenotypes should be assessed.
Obinutuzumab (GA-101), ibrutinib, and venetoclax (GIVe) frontline treatment for high-risk chronic lymphocytic leukemia
Authors: Henriette Huber, Simone Edenhofer, Julia von Tresckow, Sandra Robrecht, Can Zhang, Eugen Tausch, Christof Schneider, Johannes Bloehdorn, Moritz Fürstenau, Peter Dreger, Matthias Ritgen, Thomas Illmer, Anna L. Illert, Jan Dürig, Sebastian Böttcher, Carsten U. Niemann, Michael Kneba, Anna-Maria Fink, Kirsten Fischer, Hartmut Döhner, Michael Hallek, Barbara Eichhorst, Stephan Stilgenbauer
Journal: Blood (2022)
Re: Logan G. Briggs, Chanan Reitblat, Paul A. Bain, et al. Prehabilitation Exercise Before Urologic Cancer Surgery: A Systematic and Interdisciplinary Review. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2021.05.015
Authors: Kenta Ushida, Miho Shimizu, Ryo Momosaki
Journal: European Urology (2021)