tbuckley/cabot-search huggingface dataset:
1099MO Durvalumab plus tremelimumab influence on response to subsequent treatments in patients with neuroendocrine neoplasms (NENs) of gastroenteropancreatic and lung origins: Results from the phase II DUNE trial (GETNE 1601)
Authors: J. Hernando, J.L. Manzano, A. Teule, C. López, R. Garcia-Carbonero, M. Benavent Viñuales, A. Custodio, A. Cubillo, V. Alonso, T. Alonso-Gordoa, A. Carmona-Bayonas, G. Crespo, M. Blanco, P. Jimenez-Fonseca, A. Viudez, A. La Casta, I. Sevilla, M. Llanos, Á. Segura, J. Capdevila
Journal: Annals of Oncology (2021)
Pediatric COVID-19 Cases in Counties With and Without School Mask Requirements — United States, July 1–September 4, 2021
Authors: Samantha E. Budzyn, Mark J. Panaggio, Sharyn E. Parks, Marc Papazian, Jake Magid, M Eng, Lisa C. Barrios
Journal: MMWR Morbidity and Mortality Weekly Report (2021)

Consistent and correct mask use is a critical strategy for preventing the transmission of SARS-CoV-2, the virus that causes COVID-19 (1). CDC recommends that schools require universal indoor mask use for students, staff members, and others in kindergarten through grade 12 (K-12) school settings (2). As U.S. schools opened for the 2021-22 school year in the midst of increasing community spread of COVID-19, some states, counties, and school districts implemented mask requirements in schools. To assess the impact of masking in schools on COVID-19 incidence among K-12 students across the United States, CDC assessed differences between county-level pediatric COVID-19 case rates in schools with and without school mask requirements.
Association of Coronary Artery Bypass Grafting vs Percutaneous Coronary Intervention With Memory Decline in Older Adults—Reply
Authors: Elizabeth L. Whitlock, M. Maria Glymour
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
1454P A prospective trial evaluating the impact of tele-palliative care in cancer patients: Exploring opportunities in adversities
Authors: S.H. Kombathula, P. Pareek, S. Srinivasan, D.H. Kannikanti, A. Solanki, R.K. Vyas, M. Kamal, J.R. Vishnoi, P. Bhardwaj, S. Misra
Journal: Annals of Oncology (2021)
1697TiP Evaluation of gonyautoxins (GTX) on objective and subjective symptoms of chemotherapy-induced peripheral neuropathy (CIPN)
Authors: M.S.F. Dias, R.C. Guimarães, L. Landeiro, F.S. Lima, R. Dienstmann, F.D.O.M. Rondao, J.A.F. Canedo, B.L. Ferrari, C.G.M. Ferreira, C.S. Orellana
Journal: Annals of Oncology (2021)
1145P Reliable detection of BRCA1 and BRCA2 large genomic rearrangements in FFPE tissue: A new diagnostic benchmark for somatic BRCA testing
Authors: N. Valtcheva, B.D. Nguyen, U. Wagner, S. Freiberger, Z. Varga, C. Britschgi, K.J. Dedes, M. Rechsteiner
Journal: Annals of Oncology (2021)
Interactions of Age and Blood Immune Factors and Noninvasive Prediction of Glioma Survival
Authors: Annette M Molinaro, John K Wiencke, Gayathri Warrier, Devin C Koestler, Pranathi Chunduru, Ji Yoon Lee, Helen M Hansen, Sean Lee, Joaquin Anguiano, Terri Rice, Paige M Bracci, Lucie McCoy, Lucas A Salas, Brock C Christensen, Margaret Wrensch, Karl T Kelsey, Jennie W Taylor, Jennifer L Clarke
Journal: JNCI Journal of the National Cancer Institute (2021)

Abstract Background Tumor-based classification of human glioma portends patient prognosis, but considerable unexplained survival variability remains. Host factors (eg, age) also strongly influence survival times, partly reflecting a compromised immune system. How blood epigenetic measures of immune characteristics and age augment molecular classifications in glioma survival has not been investigated. We assess the prognostic impact of immune cell fractions and epigenetic age in archived blood across glioma molecular subtypes for the first time. Methods We evaluated immune cell fractions and epigenetic age in archived blood from the University of California San Francisco Adult Glioma Study, which included a training set of 197 patients with IDH-wild type, 1p19q intact, TERT wild type (IDH/1p19q/TERT-WT) glioma, an evaluation set of 350 patients with other subtypes of glioma, and 454 patients without glioma. Results IDH/1p19q/TERT-WT patients had lower lymphocyte fractions (CD4+ T, CD8+ T, natural killer, and B cells) and higher neutrophil fractions than people without glioma. Recursive partitioning analysis delineated 4 statistically significantly different survival groups for patients with IDH/1p19q/TERT-WT based on an interaction between chronological age and 2 blood immune factors, CD4+ T cells, and neutrophils. Median overall survival ranged from 0.76 years (95% confidence interval = 0.55-0.99) for the worst survival group (n = 28) to 9.72 years (95% confidence interval = 6.18 to not available) for the best (n = 33). The recursive partitioning analysis also statistically significantly delineated 4 risk groups in patients with other glioma subtypes. Conclusions The delineation of different survival groups in the training and evaluation sets based on an interaction between chronological age and blood immune characteristics suggests that common host immune factors among different glioma types may affect survival. The ability of DNA methylation-based markers of immune status to capture diverse, clinically relevant information may facilitate noninvasive, personalized patient evaluation in the neuro-oncology clinic.
1126P Budget impact of Oncotype DX test compared to further gene expression tests in patients with early breast cancer in Germany
Authors: M.P. Lux, C. Minartz, H. Müller-Huesmann, M-F. Sandor, K.H. Herrmann, S. Radeck-Knorre, A.S. Neubauer
Journal: Annals of Oncology (2021)
Low-pressure endoscopy using the gel immersion method facilitates endoscopic hemostasis of duodenal diverticular bleeding
Authors: Hiroki Hayashi, Tomonori Yano, Kunihiko Oguro, Shiori Yoshimoto, Hiroaki Nomoto, Alan Kawarai Lefor, Hironori Yamamoto
Journal: Endoscopy (2021)

Duodenal diverticular bleeding is an uncommon cause of upper gastrointestinal bleeding, and the optimal treatment remains controversial [1]. Since duodenal diverticula lack a muscle layer, precise endoscopic hemostasis is required to prevent perforation. However, the lumen of the diverticulum easily fills with blood, and the redundant loop in the stomach limits the maneuverability of the endoscope. These factors make precise endoscopic hemostasis difficult.
Peribiliary cysts: diagnostic features on endoscopic ultrasound and digital cholangioscopy
Authors: Michiel Bronswijk, Diederik Persyn, Thomas Billiet, Ruben Spitaels, Hannah van Malenstein, Schalk Van der Merwe
Journal: Endoscopy (2021)

Various diseases have been associated with hepatobiliary cysts, such as autosomal dominant polycystic liver disease (ADPLD) and primary bile duct cysts. Acquired peribiliary cysts are however less well known. These cystic lesions may develop in the intrahepatic and/or extrahepatic bile duct wall and correlate with peribiliary gland ectasia on histology [1]. These intramural cysts may vary in size, typically ranging from 1 mm to 8 mm, and should be considered a potential cause of bile duct compression and dilation [1] [2] [3]. While association with ADPLD has been described, alcohol-induced peribiliary gland injury is regarded as a major driver of peribiliary gland ectasia and subsequent cyst formation [1] [2].
588P Androgen changes after enzalutamide or abiraterone plus prednisone in men with castration-resistant prostate cancer (HEAT): Results from a randomised clinical trial
Authors: K. Kvorning Ternov, J. Sønksen, M. Fode, H. Lindberg, C. Kistorp, R. Bisbjerg, J. Faber, G. Palapattu, P. Østergren
Journal: Annals of Oncology (2021)
69P Transferrin saturation shows high prevalence of iron deficiency in cancer patients under adjuvant and neo-adjuvant treatment
Authors: E. Luporsi-Gely, A. Turpin, V. Massard, S. Morin, H. Simon, A-M. Ruppert, S. Belarbia, B. Chauffert, A. Lopez, A. Carnot
Journal: Annals of Oncology (2021)
Prior Glucose-Lowering Medication Use and 30-Day Outcomes Among 64,892 Veterans With Diabetes and COVID-19
Authors: Pandora L. Wander, Elliott Lowy, Lauren A. Beste, Luis Tulloch-Palomino, Anna Korpak, Alexander C. Peterson, Steven E. Kahn, Edward J. Boyko
Journal: Diabetes Care (2021)

OBJECTIVE To identify preinfection risk factors for adverse outcomes among veterans with diabetes and coronavirus disease 2019 (COVID-19) infection. RESEARCH DESIGN AND METHODS We identified all Veterans Health Administration patients with diabetes and one or more positive nasal swab(s) for severe acute respiratory syndrome coronavirus 2 (1 March 2020–10 March 2021) (n = 64,892). We examined associations of HbA1c and glucose-lowering medication use with hospitalization, intensive care unit (ICU) admission, and mortality at 30 days using logistic regression models and during 4.4 months of follow-up (range &amp;lt;1–13.1) using proportional hazards models. RESULTS Compared with HbA1c &amp;lt;7.0%, HbA1c ≥9.0% was associated with higher odds of hospitalization, ICU admission, and death at 30 days (odds ratio [OR] 1.27 [95% CI 1.19–1.35], 1.28 [95% CI 1.15–1.42], 1.30 [95% CI 1.17–1.44], respectively) as well as higher risk of death over 4.4 months (hazard ratio [HR] 1.22 [95% CI 1.12–1.32]). Insulin use was associated with higher odds of hospitalization, ICU admission, and death (OR 1.12 [95% CI 1.07–1.18], 1.12 [95% CI 1.04–1.22], and 1.18 [95% CI 1.09–1.27], respectively) and higher risk of death (HR 1.12 [95% CI 1.07–1.18]). Sodium–glucose cotransporter 2 inhibitor (SGLT2i), glucagon-like peptide-1 receptor agonist (GLP1-RA), or angiotensin receptor blocker use were associated with lower odds of hospitalization (OR 0.92 [95% CI 0.85–0.99], 0.88 [95% CI 0.81–0.96], and 0.94 [95% CI 0.89–0.99], respectively). Metformin and SGLT2i use were associated with lower odds (OR 0.84 [95% CI 0.78–0.91], 0.82 [95% CI 0.72–0.94], respectively) and risk of death (HR 0.84 [95% CI 0.79–0.89], 0.82 [95% CI 0.74–0.92], respectively). CONCLUSIONS Among veterans with diabetes and COVID-19, higher HbA1c and insulin use were directly associated with adverse outcomes, while use of a GLP1-RA, metformin, and SGLT2i was inversely associated.
1300P A phase Ib/II trial of AK104 (PD-1/CTLA-4 bispecific antibody) in combination with anlotinib in advanced NSCLC
Authors: L. Wu, B. Chen, W. Yao, X. Li, Z. Xiao, H. Liu, Y. Kong, L. Liu, Y. Xu, Q. Wang, J. Li, F. Xu, L. Xu, K. Li, W. Song, B. Li, Z.M. Wang, Y. Xia
Journal: Annals of Oncology (2021)
154P Five-year follow-up of the phase III study comparing SB3 (trastuzumab biosimilar) and reference trastuzumab in patients with HER2 positive early or locally advanced breast cancer
Authors: X. Pivot, O. Burian, F. Bazan, M. Wojtukiewicz, H. Jang, S. Kim, J. Lee, Y.C. Yoon
Journal: Annals of Oncology (2021)
Organoids Derived from Neoadjuvant FOLFIRINOX Patients Recapitulate Therapy Resistance in Pancreatic Ductal Adenocarcinoma
Authors: Elham Aida Farshadi, Jiang Chang, Bharath Sampadi, Michail Doukas, Freek Van 't Land, Fleur van der Sijde, Eveline E. Vietsch, Joris Pothof, Bas Groot Koerkamp, Casper H.J. van Eijck
Journal: Clinical Cancer Research (2021)

Abstract Purpose: We investigated whether organoids can be generated from resected tumors of patients who received eight cycles of neoadjuvant FOLFIRINOX chemotherapy before surgery, and evaluated the sensitivity/resistance of these surviving cancer cells to cancer therapy. Experimental Design: We generated a library of 10 pancreatic ductal adenocarcinoma (PDAC) organoid lines: five each from treatment-naïve and FOLFIRINOX-treated patients. We first assessed the histologic, genetic, and transcriptional characteristics of the organoids and their matched primary PDAC tissue. Next, the organoids' response to treatment with single agents—5-FU, irinotecan, and oxaliplatin—of the FOLFIRINOX regimen as well as combined regimen was evaluated. Finally, global mRNA-seq analyses were performed to identify FOLFIRINOX resistance pathways. Results: All 10 patient-derived PDAC organoids recapitulate histologic, genetic, and transcriptional characteristics of their primary tumor tissue. Neoadjuvant FOLFIRINOX-treated organoids display resistance to FOLFIRINOX (5/5), irinotecan (5/5), and oxaliplatin (4/5) when compared with treatment-naïve organoids (FOLFIRINOX: 1/5, irinotecan: 2/5, oxaliplatin: 0/5). 5-Fluorouracil treatment responses between naïve and treated organoids were similar. Comparative global transcriptome analysis of treatment-naïve and FOLFIRINOX samples—in both organoids and corresponding matched tumor tissues—uncovered modulated pathways mainly involved in genomic instability, energy metabolism, and innate immune system. Conclusions: Resistance development in neoadjuvant FOLFIRINOX organoids, recapitulating their primary tumor resistance, suggests continuation of FOLFIRINOX therapy as an adjuvant treatment may not be advantageous for these patients. Gene-expression profiles of PDAC organoids identify targetable pathways involved in chemoresistance development upon neoadjuvant FOLFIRINOX treatment, thus opening up combination therapy possibilities.
1805P Assistance with an artificial intelligence-powered PD-L1 analyzer reduces interobserver variation in pathologic reading of tumor proportion score in non-small cell lung cancer
Authors: S. Choi, S. Kim, H. Kim, S. Cho, M. Ma, S. Park, S. Pereira, B.J. Aum, S. Shin, K. Paeng, D. Yoo, W. Jung, C-Y. Ock, S-H. Lee, Y-L. Choi, J-H. Chung, T.S.K. Mok
Journal: Annals of Oncology (2021)
477P Utilisation and predictors of genomic testing prior to first-line (1L) therapy in patients (pts) with metastatic colorectal cancer (mCRC)
Authors: H.J. Lenz, J. Weberpals, C. Cremolini, A. Grothey, B. Leutgeb, S. Mahrus, H. Nimeiri, I. Reyes-Rivera, J. Seligmann, J. Tabernero, S. Tejpar, T. Yoshino, S. Stintzing
Journal: Annals of Oncology (2021)
654MO A phase II prospective trial of frontline cabozantinib in metastatic collecting ducts renal cell carcinoma: The BONSAI trial (Meeturo 2)
Authors: G. Procopio, M. Claps, P. Sepe, S. Buti, L. de Cecco, A. Devecchi, M. Dugo, C. Gargiuli, V. Guadalupi, A. Ottini, M. Sensi, F. De Braud, E. Verzoni
Journal: Annals of Oncology (2021)
Short‐Term Preclinical Application of Functional Human Induced Pluripotent Stem Cell‐Derived Airway Epithelial Patches
Authors: Ratna Varma, Alba E. Marin‐Araujo, Sara Rostami, Thomas K. Waddell, Golnaz Karoubi, Siba Haykal
Journal: Advanced Healthcare Materials (2021)

Airway pathologies including cancer, trauma, and stenosis lack effective treatments, meanwhile airway transplantation and available tissue engineering approaches fail due to epithelial dysfunction. Autologous progenitors do not meet the clinical need for regeneration due to their insufficient expansion and differentiation, for which human induced pluripotent stem cells (hiPSCs) are promising alternatives. Airway epithelial patches are engineered by differentiating hiPSC-derived airway progenitors into physiological proportions of ciliated (73.9 ± 5.5%) and goblet (2.1 ± 1.4%) cells on a silk fibroin-collagen vitrigel membrane (SF-CVM) composite biomaterial for transplantation in porcine tracheal defects ex vivo and in vivo. Evaluation of ex vivo tracheal repair using hiPSC-derived SF-CVM patches demonstrate native-like tracheal epithelial metabolism and maintenance of mucociliary epithelium to day 3. In vivo studies demonstrate SF-CVM integration and maintenance of airway patency, showing 80.8 ± 3.6% graft coverage with an hiPSC-derived pseudostratified epithelium and 70.7 ± 2.3% coverage with viable cells, 3 days postoperatively. The utility of bioengineered, hiPSC-derived epithelial patches for airway repair is demonstrated in a short-term preclinical survival model, providing a significant leap for airway reconstruction approaches.
1087P The importance of anti-PD-1 dosing in the treatment of patients with inoperable or metastatic melanoma
Authors: B. Cybulska-Stopa, A.M. Czarnecka, K. Ostaszewski, M. Ziętek, K. Piejko, R. Dziura, L. Galus, B.E. Ziolkowska, S. Kieszko, N. Kempa-Kaminska, J. Calik, J. Seredyńska, P. Rogala, A. Drosik-Kwaśniewska, G. Kamińska-Winciorek, T. Kubiatowski, R. Suwinski, J. Mackiewicz, P. Rutkowski
Journal: Annals of Oncology (2021)
405P Prognostic value of neoadjuvant rectal score in patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy
Authors: A.C. Caetano, J.C. Monteiro, C. Costa, F.R. Salgueiro, M.R. Pires, A.R. Monteiro, J. Paulo, P. Jacinto, N. Bonito, G. Sousa
Journal: Annals of Oncology (2021)
648TiP PSMAfore: A phase III study to compare 177Lu-PSMA-617 treatment with a change in androgen receptor pathway inhibitor in taxane-naïve patients with mCRPC
Authors: M.J. Morris, O. Sartor, K.N. Chi, J.S. de Bono, N.D. Shore, M. Crosby, D. Dalal, K. Fizazi
Journal: Annals of Oncology (2021)
Challenging infant-directed singing as a credible signal of maternal attention
Authors: Sandra E. Trehub
Journal: Behavioral and Brain Sciences (2021)

I challenge Mehr et al.'s contention that ancestral mothers were reluctant to provide all the attention demanded by their infants. The societies in which music emerged likely involved foraging mothers who engaged in extensive infant carrying, feeding, and soothing. Accordingly, their singing was multimodal, its rhythms aligned with maternal movements, with arousal regulatory consequences for singers and listeners.
Addressing Biased Patient Behavior
Authors: Virginia Sheffield, Luke Fraley, Govind Warrier
Journal: JAMA Internal Medicine (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
癌に関する国際無作為化臨床試験からの患者報告転帰の予後的価値:系統的レビュー【JST・京大機械翻訳】
Authors: Mierzynska Justyna, Piccinin Claire, Pe Madeline, Martinelli Francesca, Gotay Carolyn, Coens Corneel, Mauer Murielle, Eggermont Alexander, Groenvold Mogens, Bjordal Kristin, Reijneveld Jaap, Velikova Galina, Bottomley Andrew
Journal: The Lancet Oncology (2019)
1094TiP A randomized, controlled, open-label, phase II study of cemiplimab as a single agent and in combination with RP1 in patients with advanced cutaneous squamous cell carcinoma [CERPASS]
Authors: A.M. Haydon, M. Alamgeer, D. Brungs, F. Collichio, N.I. Khushalani, A.D. Colevas, D. Rischin, R. Kudchadkar, W. Chai-Ho, G. Daniels, J. Lutzky, J.H. Lee, S. Bowyer, M.R. Migden, P. Sheladia, P.K. Bommareddy, S. He, C. Andreu-Vieyra, M.G. Fury, A. Hill
Journal: Annals of Oncology (2021)
Bmal1 regulates production of larger lipoproteins by modulating cAMP‐responsive element‐binding protein H and apolipoprotein AIV
Authors: Xiaoyue Pan, M. Mahmood Hussain
Journal: Hepatology (2021)

Abstract Background and Aims High plasma lipid/lipoprotein levels are risk factors for various metabolic diseases. We previously showed that circadian rhythms regulate plasma lipids and deregulation of these rhythms causes hyperlipidemia and atherosclerosis in mice. Here, we show that global and liver‐specific brain and muscle aryl hydrocarbon receptor nuclear translocator‐like 1 (Bmal1)‐deficient mice maintained on a chow or Western diet developed hyperlipidemia, denoted by the presence of higher amounts of triglyceride‐rich and apolipoprotein AIV (ApoAIV)‐rich larger chylomicron and VLDL due to overproduction. Approach and Results Bmal1 deficiency decreased small heterodimer partner (Shp) and increased microsomal triglyceride transfer protein (MTP), a key protein that facilitates primordial lipoprotein assembly and secretion. Moreover, we show that Bmal1 regulates cAMP‐responsive element‐binding protein H (Crebh) to modulate ApoAIV expression and the assembly of larger lipoproteins. This is supported by the observation that Crebh‐deficient and ApoAIV‐deficient mice, along with Bmal1‐deficient mice with knockdown of Crebh, had smaller lipoproteins. Further, overexpression of Bmal1 in Crebh‐deficient mice had no effect on ApoAIV expression and lipoprotein size. Conclusions These studies indicate that regulation of ApoAIV and assembly of larger lipoproteins by Bmal1 requires Crebh. Mechanistic studies showed that Bmal1 regulates Crebh expression by two mechanisms. First, Bmal1 interacts with the Crebh promoter to control circadian regulation. Second, Bmal1 increases Rev‐erbα expression, and nuclear receptor subfamily 1 group D member 1 (Nr1D1, Rev‐erbα) interacts with the Crebh promoter to repress expression. In short, Bmal1 modulates both the synthesis of primordial lipoproteins and their subsequent expansion into larger lipoproteins by regulating two different proteins, MTP and ApoAIV, through two different transcription factors, Shp and Crebh. It is likely that disruptions in circadian mechanisms contribute to hyperlipidemia and that avoiding disruptions in circadian rhythms may limit/prevent hyperlipidemia and atherosclerosis.