tbuckley/cabot-search huggingface dataset:
A panel of selected serum protein biomarkers for the detection of aggressive prostate cancer
Authors: Jin Song, Shiyong Ma, Lori J Sokoll, Rodrigo V Eguez, Naseruddin Höti, Hui Zhang, Phaedre Mohr, Renu Dua, Dattatraya Patil, Kristen Douglas May, Sierra Williams, Rebecca Arnold, Martin G Sanda, Daniel W Chan, Zhen Zhang
Journal: Theranostics (2021)

Current PSA-based tests used to detect prostate cancer (PCa) lack sufficient specificity, leading to significant overdetection and overtreatment. Our previous studies showed that serum fucosylated PSA (Fuc-PSA) and soluble TEK receptor tyrosine kinase (Tie-2) had the ability to predict aggressive (AG) PCa. Additional biomarkers are needed to address this significant clinical problem.
Delay of Pregnancy Among Physicians vs Nonphysicians
Authors: Maria C. Cusimano, Nancy N. Baxter, Rinku Sutradhar, Eric McArthur, Joel G. Ray, Amit X. Garg, Simone Vigod, Andrea N. Simpson
Journal: JAMA Internal Medicine (2021)

<h3>Importance</h3> Women physicians may delay childbearing and experience childlessness more often than nonphysicians, but existing knowledge is based largely on self-reported survey data. <h3>Objective</h3> To compare patterns of childbirth between physicians and nonphysicians. <h3>Design, Setting, and Participants</h3> Population-based retrospective cohort study of reproductive-aged women (15-50 years) in Ontario, Canada, accrued from January 1, 1995, to November 28, 2018, and observed to March 31, 2019. Outcomes of 5238 licensed physicians of the College of Physicians and Surgeons of Ontario were compared with those of 26 640 nonphysicians (sampled in a 1:5 ratio). Physicians and nonphysicians were observed from age 15 years onward. <h3>Exposures</h3> Physicians vs nonphysicians. <h3>Main Outcomes and Measures</h3> The primary outcome was childbirth at gestational age of 20 weeks or greater. Cox proportional hazards models were used to examine the association between physician status and childbirth, overall and across career stage (postgraduate training vs independent practice) and specialty (family physicians vs specialists). <h3>Results</h3> All physicians (n = 5238) and nonphysicians (n = 26 640) were aged 15 years at baseline, and 28 486 (89.1%) were Canadian-born. Median follow-up was 15.2 (interquartile range, 12.2-18.2) years after age 15 years. Physicians were less likely to experience childbirth at younger ages (hazard ratio [HR] for childbirth at 15-28 years, 0.15; 95% CI, 0.14-0.18;<i>P</i> &lt; .001) and initiated childbearing significantly later than nonphysicians; the cumulative incidence of childbirth was 5% at 28.6 years in physicians and 19.4 years in nonphysicians. However, physicians were more likely to experience childbirth at older ages (HR for 29-36 years, 1.35; 95% CI, 1.28-1.43;<i>P</i> &lt; .001; HR for ≥37 years, 2.62; 95% CI, 2.00-3.43;<i>P</i> &lt; .001), and ultimately achieved a similar cumulative probability of childbirth as nonphysicians overall. Median age at first childbirth was 32 years in physicians and 27 years in nonphysicians (<i>P</i> &lt; .001). After stratifying by specialty, the cumulative incidence of childbirth was higher in family physicians than in both surgical and nonsurgical specialists at all observed ages. <h3>Conclusions and Relevance</h3> The findings of this cohort study suggest that women physicians appear to delay childbearing compared with nonphysicians, and this phenomenon is most pronounced among specialists. Physicians ultimately appear to catch up to nonphysicians by initiating reproduction at older ages and may be at increased risk of resulting adverse reproductive outcomes. System-level interventions should be considered to support women physicians who wish to have children at all career stages.
Abstract 13422: Long Term Association of Low Density Lipoprotein Patterns With Coronary Artery Calcium and Atherosclerotic Cardiovascular Disease Events: Insights From HeartSCORE Study
Authors: Anum Saeed, Justin Swanson, Gul J Saeed, Kevin Kip, Steven Reis
Journal: Circulation (2020)

Introduction: Low-density lipoprotein (LDL) cholesterol, a factor in progression of atherosclerotic cardiovascular disease (CVD), consists of sub-fractions with different sizes and densities in three patterns (A (large buoyant), B (small dense), AB (intermediate pattern). We examined the associations of LDL patterns with subclinical ASCVD and future events. Methods: Participants from the Heart Strategies Concentrating on Risk Evaluation (HeartSCORE) study were assessed for baseline lipid levels and LDL sub-fraction types by an ultracentrifugation method (vertical auto profile). Electron beam CT scans were obtained in a subset of individuals and coronary artery calcium (CAC) scores were calculated (Agatston method). Adjusted odds ratios and hazard ratios (95% CI) were calculated using logistic regression and Cox regression, respectively, to estimate the independent association between LDL sub-fractions and both; CAC and ASCVD events (MI, ischemic stroke, death), respectively. Results: Among 1884 eligible participants (mean [SD] age; 59[7.5]y, 65.8% women, 37.9% black), mean HDL-c, LDL-c and Triglycerides were 142.2[36.0]mg/dL, 58.2[14.9]mg/dL and 111.2[47.7]mmHg, respectively. Sub-fractions of LDL pattern A, B and AB were observed in 761(40%), 507(26.9%) and 616(32.7%) individuals. Over a follow up of ~16y, patterns B(1.98[1.22-3.21) and AB (1.54[1.00-2.38)] were independently associated with incident risk of CVD events (vs pattern A). When stratified by race and gender, pattern AB showed independent risk of incident CVD events and CAC presence among blacks and males (Table) . Conclusions: In this biracial cohort of middle-aged adults, LDL sub-fraction patterns B and AB showed a significantly higher risk of long-term CVD events. Pattern AB was also associated with positive CAC in blacks and males. Further studies are needed to investigate LDL patterns in CVD risk profiling based on race and gender.
Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder: Diagnosis and management
Authors: Jake G. Besch-Stokes, Collin M. Costello, Kevin J. Severson, Puneet Bhullar, Jordan Montoya, Richard J. Butterfield, David J. DiCaudo, Nneka Comfere, Jason Sluzevich, William Rule, Fiona E. Craig, Allison Rosenthal, Mark R. Pittelkow, Aaron R. Mangold
Journal: Journal of the American Academy of Dermatology (2021)
DSCAM/PAK1 pathway suppression reverses neurogenesis deficits in iPSC-derived cerebral organoids from patients with Down syndrome
Authors: Xiao-Yan Tang, Lei Xu, Jingshen Wang, Yuan Hong, Yuanyuan Wang, Qian Zhu, Da Wang, Xin-Yue Zhang, Chun-Yue Liu, Kai-Heng Fang, Xiao Han, Shihua Wang, Xin Wang, Min Xu, Anita Bhattacharyya, Xing Guo, Mingyan Lin, Yan Liu
Journal: Journal of Clinical Investigation (2021)

Down syndrome (DS), caused by trisomy of chromosome 21, occurs in 1 of every 800 live births. Early defects in cortical development likely account for the cognitive impairments in DS, although the underlying molecular mechanism remains elusive. Here, we performed histological assays and unbiased single-cell RNA-Seq (scRNA-Seq) analysis on cerebral organoids derived from 4 euploid cell lines and from induced pluripotent stem cells (iPSCs) from 3 individuals with trisomy 21 to explore cell-type–specific abnormalities associated with DS during early brain development. We found that neurogenesis was significantly affected, given the diminished proliferation and decreased expression of layer II and IV markers in cortical neurons in the subcortical regions; this may have been responsible for the reduced size of the organoids. Furthermore, suppression of the DSCAM/PAK1 pathway, which showed enhanced activity in DS, using CRISPR/Cas9, CRISPR interference (CRISPRi), or small-molecule inhibitor treatment reversed abnormal neurogenesis, thereby increasing the size of organoids derived from DS iPSCs. Our study demonstrates that 3D cortical organoids developed in vitro are a valuable model of DS and provide a direct link between dysregulation of the DSCAM/PAK1 pathway and developmental brain defects in DS.
Abstract 12917: Prognostic Value of the Combination of Model for End-stage Liver Disease Excluding Inr Score and Non-alcoholic Fatty Liver Disease Fibrosis Score in Patients Admitted for Acute Heart Failure
Authors: Masatsugu Kawahira, Takahisa Yamada, Tetsuya Watanabe, Takashi Morita, Yoshio Furukawa, Shunsuke Tamaki, Masato Kawasaki, Atsushi Kikuchi, Tsutomu Kawai, Masahiro Seo, Jun Nakamura, Kiyomi Kayama, Masatake Fukunami
Journal: Circulation (2020)

Background: Cardiohepatic interactions have been a focus of attention in heart failure(HF), and the model for end-stage liver disease excluding INR (MELD-XI) has been shown to be useful for prediction of poor outcome in patients (pts) with acute decompensated heart failure (ADHF). Furthermore, it has been reported that liver stiffness predicts adverse prognosis in pts with HF. Liver fibrosis is assessed by non-invasive fibrosis markers such as Fibrosis-4 (FIB4) index, non-alcoholic fatty liver disease fibrosis score (NFS) and aminotransferase to platelet ratio index (APRI). Recently, a new group of HF pts with mid-range ejection fraction (HFmrEF) has been defined, separated from reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF). However, there is little information available on the comparison of prognostic significance of MELD-XI and liver fibrosis scores in ADHF pts, relating to LVEF. Methods: We prospectively studied 466 consecutive ADHF pts (HFrEF (LVEF≦40%): n=164, HFmrEF (40&lt;LVEF&lt;50): n=104 and HFpEF (LVEF≧50%): n=198). At the discharge, we calculated MELD-XI, FIB4 index , NFS, and APRI. The endpoint was all cause death (ACD). Results: During a follow-up period of 2.8±1.5 years, 143 pts had ACD. At multivariate Cox analysis, MELD-XI and FIB4 index was independently associated with ACD irrespective of LVEF. The pts with both greater MELD-XI ([HFrEF]≥25.8, [HFmrEF]≥33.2, [HFpEF]≥30.1) and greater FIB4 index ([HFrEF]≥2.58, [HFmrEF]≥2.58, [HFpEF]≥2.22) had a significantly increased risk of ACD than those with either and none of them in all three groups. Conclusions: The combination of MELD-XI and FIB4 index might be useful for stratifying pts at risk for ACD in ADHF pts with irrespective of LVEF.
EVALUATION OF CRITICAL TEMPERATURE ISOTHERMS BY INFRARED THERMOGRAPHY DURING RADIOFREQUENCY ABLATION USING HALF-NORMAL AND NORMAL SALINE IRRIGATION
Authors: Henry Darchon Huang, Paul Rhodes, Venkatesh Ravi, Jeffrey Winterfield, Jeremiah Wasserlauf, Kousik Krishnan, Parikshit Sharma, Richard Trohman, Timothy Larsen
Journal: Journal of the American College of Cardiology (2021)
IMPACT OF RACE ON OUTCOMES FROM CATHETER ABLATION FOR SCAR-RELATED VENTRICULAR TACHYCARDIA: A PROSPECTIVE REGISTRY FROM SOUTH METROPOLITAN CHICAGO
Authors: Nathan Kong, Dalise Shatz, Stephanie Besser, Zaid Aziz, Cevher Ozcan, Andrew Beaser, Gaurav Upadhyay, Hemal Nayak, Roderick Tung
Journal: Journal of the American College of Cardiology (2021)
RELATIONSHIP BETWEEN UNRECOGNIZED MYOCARDIAL INFARCTION ON CARDIAC MAGNETIC RESONANCE IMAGING AND UNDERLYING CORONARY PLAQUE CHARACTERISTICS ON OPTICAL COHERENCE TOMOGRAPHY
Authors: Tomoyo Sugiyama, Yoshihisa Kanaji, Masahiro Hoshino, Masao Yamaguchi, Masahiro Hada, Toru Misawa, Tatsuhiro Nagamine, Kai Nogami, Yumi Yasui, Taishi Yonetsu, Tetsuo Sasano, Tsunekazu Kakuta
Journal: Journal of the American College of Cardiology (2021)
Abstract 11850: Predicting Long-term Survival After Heart Transplant Using Post-transplant Cardiopulmonary Stress Tests
Authors: Thomas C Hanff, Robert S Zhang, Yuhui Zhang, Maria Molina, Rhondalyn C McLean, Jeremy A Mazurek, Monique Tanna, J Eduardo Rame, Joyce W Wald, Pavan Atluri, Michael A Acker, Mariell Jessup, Lee R Goldberg, Edo Y Birati
Journal: Circulation (2019)

Introduction: The prognostic power of peak oxygen uptake (VO2Peak) is well established in patients with advanced heart failure. Although VO2Peak typically increases after heart transplantation, the...
RELATIVE APICAL SPARING PATTERN IN PATIENTS WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION (THE PARAGON-HF AND TOPCAT TRIALS)
Authors: Masatoshi Minamisawa, Sarah Cuddy, Brian Claggett, Maja Cikes, Margaret Redfield, Sanjiv Shah, Pablo Garcia-Pavia, Michael Zile, Jean Rouleau, Milton Packer, Marc Pfeffer, John McMurray, Amil Shah, Scott Solomon
Journal: Journal of the American College of Cardiology (2021)
ASSOCIATION OF ABNORMAL ELECTROCARDIOGRAPHY RESPONSE ON STRESS ECHOCARDIOGRAM WITH MAJOR ADVERSE CARDIOVASCULAR EVENTS IN WOMEN: A REPORT FROM THE WOMEN’S ISCHEMIA SYNDROME EVALUATION (WISE) STUDY
Authors: Benita Tjoe, Chrisandra Shufelt, Janet Wei, Marie Lauzon, Jannet Lewis, Carl Pepine, Leslee Shaw, Sheryl Kelsey, Eileen Handberg, George Sopko, C. Noel Bairey Merz
Journal: Journal of the American College of Cardiology (2021)
CARDIOVASCULAR COMPLICATIONS IN HOSPITALIZED PATIENTS WITH SARS-COV-2 INFECTION AND HISTORY OF CANCER
Authors: Hasan Siddiqi, Jefferson Vieira, Guohai Zhou, Brittany Weber, Andy Kim, Henry Rutherford, Anubodh Varshney, Ankeet Bhatt, Ann Woolley, Anju Nohria
Journal: Journal of the American College of Cardiology (2021)
RARE BUT DEADLY: PROSTHETIC MITRAL VALVE ENDOCARDITIS DUE TO CELLULOSIMICROBIUM CELLULANS
Authors: Pavankumar Thota, Shehryar Jumani, Luis Chozet, Jefrina Zaman, Jewelian Baig, Megan Stevens, Jazmine Duran, Adebayo Olusanya
Journal: Journal of the American College of Cardiology (2021)
THE IMPACT OF AORTIC ANGULATION ON CONTEMPORARY TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Giorgio Medranda, Cheng Zhang, Brian Case, Charan Yerasi, Brian Forrestal, Chava Chezar-Azzerad, Toby Rogers, Itsik Ben-Dor, Lowell Satler, Ron Waksman
Journal: Journal of the American College of Cardiology (2021)
Duodenal Microbiota in Stunted Undernourished Children with Enteropathy
Authors: Rémi Le Guern, Sarah Stabler, Emmanuel Faure
Journal: New England Journal of Medicine (2021)

major reduction of new cases of Covid-19 among those who received two doses of the vaccine, even when a surge of the B.1.1.7 variant was noted in up to 80% of cases. 5 These findings suggest that widespread and effective vaccination among health care workers provides a safe environment, even in the presence of a high rate of SARS-CoV-2 infection in the community.
MATCHED HYDRATION AND FORCED DIURESIS FOR PREVENTION OF CONTRAST-INDUCED NEPHROPATHY IN PATIENTS WITH IMPAIRED RENAL FUNCTION UNDERGOING CORONARY PROCEDURES
Authors: Aram Jamal Mirza, Chim C. Lang, Abdulsalam Y. Taha, Farman J. Ahmed, Shahow A. Ezzaddin, Zana I. Abdulrahman
Journal: Journal of the American College of Cardiology (2021)
SGLT2 INHIBITORS DECREASE CARDIOVASCULAR MORTALITY OR HEART FAILURE HOSPITALIZATIONS IN HEART FAILURE SUBGROUPS: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Rhanderson Cardoso, Fabrissio P. Graffunder, Caique M.P. Ternes, Gilson Fernandes, Ana Vitoria Rocha, Deepak Bhatt
Journal: Journal of the American College of Cardiology (2021)
Abstract MP045: Global and Regional Consumption of Major Food Groups in 1990 and 2005: Systematic Analysis of Country-Specific Nutrition Surveys Worldwide.
Authors: Renata Micha, Shahab Khatibzadeh, Edward Giovannucci, John Powles, Peilin Shi, Majid Ezzati, Dariush Mozaffarian
Journal: Circulation (2012)

Background: Food-based research and policy recommendations are highly relevant in the modern era to understand and reduce the pandemics of chronic disease occurring in nearly all nations. Unfortunately, reliable and systematically assessed individual consumption data (as opposed to disappearance data) on food habits and trends have not been available on a global scale. Objective: To produce comprehensive data on consumption of major foods and their uncertainties by country, region, age, and sex in 1990 and 2005. Methods. We developed methods to identify, assess, and obtain exposure data (mean, SD) by age and sex from nationally representative diet surveys worldwide on fruits, vegetables, legumes, nuts/seeds, whole grains, seafood, red meats, processed meats, milk, and sugar-sweetened beverages. To address missing data and estimate mean intake, we developed and applied a multi-level hierarchical imputation Bayesian model that accounted for country- and region-level data, measurement comparability, study representativeness, and diet assessment method. Time-varying country-level covariates were used to inform estimates, including FAO food availability data, population, GDP, latitude, metabolic risks, and other diet covariates. Uncertainty of the estimates accounted for uncertainty from sampling and statistical modeling. Results: We obtained relevant data (85% by direct author contact) from 165 nationally and 40 non-nationally representative surveys from 109 countries in 20 regions, covering 79% of the global population. Data were most frequently available for fruits and vegetables (Figure). Findings for other foods will be presented at the meeting. Conclusions: Our systematic analysis of representative country-specific nutrition surveys on a global scale has produced estimates of the exposure distribution of major foods by age, sex, country, region, and time period. Such global assessment is crucial to estimate the impact of diet on chronic diseases worldwide.
COMPARATIVE CARDIOVASCULAR EFFECTIVENESS AND SAFETY OF INDIVIDUAL ANGIOTENSIN-CONVERTING ENZYME INHIBITORS AND ANGIOTENSIN RECEPTOR BLOCKERS: A MULTINATIONAL PARTICIPANT-LEVEL ASSESSMENT FROM LEGEND-HTN
Authors: Rohan Khera, Yuan Lu, Ruijun Chen, Martijn Schuemie, George Hripcsak, Harlan Krumholz, Marc Suchard
Journal: Journal of the American College of Cardiology (2021)
A global public health convention for the 21st century
Authors: Johnathan H Duff, Anicca Liu, Jorge Saavedra, Jacob N Batycki, Kendra Morancy, Barbara Stocking, Lawrence O Gostin, Sandro Galea, Stefano Bertozzi, Jose M Zuniga, Carmencita Alberto-Banatin, Akua Sena Dansua, Carlos del Rio, Maksut Kulzhanov, Kelley Lee, Gisela Scaglia, Cyrus Shahpar, Andrew J Ullmann, Steven J Hoffman, Michael Weinstein, José Szapocznik
Journal: The Lancet Public Health (2021)

As shown by COVID-19, infectious diseases with a pandemic potential present a grave threat to health and wellbeing. Although the International Health Regulations provide a framework of binding legal obligations for pandemic prevention, preparedness, and response, many countries do not comply with these regulations. There is a need for a renewed framework for global collective action that ensures conformity with international regulations and promotes effective prevention and response to pandemic infectious diseases. This Health Policy identifies the necessary characteristics for a new global public health security convention designed to optimise prevention, preparedness, and response to pandemic infectious diseases. We propose ten recommendations to strengthen global public health governance and promote compliance with global health security regulations. Recommendations for a new global public health security convention include greater authority for a global governing body, an improved ability to respond to pandemics, an objective evaluation system for national core public health capacities, more effective enforcement mechanisms, independent and sustainable funding, representativeness, and investment from multiple sectors, among others. The next steps to achieve these recommendations include assembling an invested alliance, specifying the operational structures of a global public health security system, and overcoming barriers such as insufficient political will, scarcity of resources, and individual national interests.
IS RENIN ANGIOTENSIN SYSTEM MODULATION BENEFICIAL IN HEART FAILURE PATIENTS WITH END-STAGE RENAL DISEASE
Authors: Muhammad Saad, Shoaib Ashraf, Upreti Prakash, Nikee Shrestha, Sarthak Kulshrestha, Muhammad Hassan, Yue Bing, Haiming Tang, Timothy J. Vittorio
Journal: Journal of the American College of Cardiology (2021)
ACUTE THROMBOCYTOPENIA IN A PATIENT WITH LEFT ANTERIOR DESCENDING ARTERY ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION
Authors: Rod Partow-Navid, Patrick Baghdasaryan, Preston Sitorus, Gurjot Walia, Sami Nazzal, Prabhdeep Sethi
Journal: Journal of the American College of Cardiology (2021)
ASSOCIATIONS OF URINARY ISOPROSTANES WITH INCIDENCE AND PROGRESSION OF THORACIC AORTIC CALCIFICATION: THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA)
Authors: Ryan Wallace, Erin Michos, Di Zhao, Oluseye Ogunmoroti, Wendy Post, Dhananjay Vaidya, Pamela Ouyang, Amir Heravi, Chiadi Ndumele, Matthew Budoff, Isac Thomas, Oluwaseun Fashanu
Journal: Journal of the American College of Cardiology (2021)
The effects of seasons and weather on sleep patterns measured through longitudinal multimodal sensing
Authors: Stephen M. Mattingly, Ted Grover, Gonzalo J. Martinez, Talayeh Aledavood, Pablo Robles-Granda, Kari Nies, Aaron Striegel, Gloria Mark
Journal: npj Digital Medicine (2021)

Abstract Previous studies of seasonal effects on sleep have yielded unclear results, likely due to methodological differences and limitations in data size and/or quality. We measured the sleep habits of 216 individuals across the U.S. over four seasons for slightly over a year using objective, continuous, and unobtrusive measures of sleep and local weather. In addition, we controlled for demographics and trait-like constructs previously identified to correlate with sleep behavior. We investigated seasonal and weather effects of sleep duration, bedtime, and wake time. We found several small but statistically significant effects of seasonal and weather effects on sleep patterns. We observe the strongest seasonal effects for wake time and sleep duration, especially during the spring season: wake times are earlier, and sleep duration decreases (compared to the reference season winter). Sleep duration also modestly decreases when day lengths get longer (between the winter and summer solstice). Bedtimes and wake times tend to be slightly later as outdoor temperature increases.
Sporadic miscarriage: evidence to provide effective care
Authors: Arri Coomarasamy, Ioannis D Gallos, Argyro Papadopoulou, Rima K Dhillon-Smith, Maya Al-Memar, Jane Brewin, Ole B Christiansen, Mary D Stephenson, Olufemi T Oladapo, Chandrika N Wijeyaratne, Rachel Small, Phillip R Bennett, Lesley Regan, Mariëtte Goddijn, Adam J Devall, Tom Bourne, Jan J Brosens, Siobhan Quenby
Journal: The Lancet (2021)
Digoxin vs Bisoprolol for Heart Rate Control in Atrial Fibrillation—Reply
Authors: Dipak Kotecha
Journal: JAMA (2021)

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ACUTE HEMODYNAMIC EFFECT OF INTRINSIC ATRIOVENTRICULAR CONDUCTION IN A LVAD PATIENT WITH ACUTE RIGHT VENTRICULAR FAILURE
Authors: Steve Marc Antoine, Catarina Canha, Diana Andersen-Davis, Juan Vilaro, Mustafa Ahmed, Eric Jeng, Juan Aranda, Mohammad Al-Ani
Journal: Journal of the American College of Cardiology (2021)