tbuckley/cabot-search huggingface dataset:
Immediate effect of contrast medium injection on left ventricular volumes and ejection fraction. A study using metallic epicardial markers.
Authors: D LVine, T DHegg, H TDodge, D KStewart, MFrimer
Journal: Circulation (1977)

The immediate effect of contrast medium injection on left ventricular (LV) volume, stroke volume (SV) and ejection fraction (EF) was evaluated from postoperative LV biplane cineangiograms of 10 patients with 4-6 epicardial markers placed at the time of coronary artery surgery. After calibrating marker distances with respect to volume (r = 0.97-0.99) over one cardiac cycle for each patient, regression equations were used to compute LV volume from marker measurements for beats prior to, during and following injection. End-diastolic volumes (EDV) prior to injection ranged from 93-263 ml and did not change significantly with injection. End-systolic volumes (ESV) showed a mean decrease of 7.3 ml by beat 7 following injection; this was of borderline significance. Similarly, there was no significant change of SV or EF until beat 7 when there were small but significant increases of 6.4 ml and 0.04, respectively. The injection of moderate amounts of contrast in man does not cause significant changes in LV volume o...
Releasing the grip of big pharma
Authors: Patrick Vallance
Journal: The Lancet (2001)

In your April 14 editorial,1Editorial. The tightening grip of big pharma.Lancet. 2001; 357: 1141Summary Full Text Full Text PDF PubMed Scopus (24) Google Scholar you draw attention to contract research agreements that contain a clause allowing suppression of publication. You suggest that academic institutions could intervene to support scientists but quite rightly point out that where commercialisation has become a priority to support institutional finances this intervention may not happen. Surely for clinical research this is a matter for ethics committees? Every ethics committee form should contain a clear question “Are you free to publish the results of this study?” Of course, a company would wish to have the opportunity to comment on any proposed publication, or might need to delay it for a specified period of time (eg, not longer than 6 months) to protect commercial interest. However, any complete embargo on publication should be a reason for rejection of the application by the ethics committee. To fail to adopt this approach would mean that volunteers in research would be subject to the inevitable risk of experimentation with the very real possibility that the results of the study would never reach the public domain.
Patching for Corneal Abrasions
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Left ventricular function during sudden strenuous exercise.
Authors: CFoster, J DAnholm, C KHellman, JCarpenter, M LPollock, D HSchmidt
Journal: Circulation (1981)

Strenuous exercise without warm-up has been shown to produce ischemia-like electrocardiographic (ECG) abnormalities in 60-70% of healthy subjects. These abnormalities appeared to be related to the development of an unfavorable myocardial supply/demand balance and, in chronically instrumented dogs, to transient decreases in coronary blood flow. A mechanism involving subendocardial ischemia has been proposed to explain the response to sudden strenuous exercise (SSE). To determine whether the response to SSE included the development of changes in myocardial pump performance typical of ischemia, left ventricular (LV) function at rest, during graded exercise and during SSE was evaluated in nine young (26.6 +/- 3.4 years), well-trained male volunteers using first-pass radionuclide angiography. During graded exercise, the LV ejection fraction increased from 66.9 +/- 9.4% at rest to 73.0 +/- 7.1% during peak exercise, and the LV ejection rate increased from 3.36 +/- 0.67 sec-1 at rest to 6.58 +/- 1.10 sec-1 durin...
"Clinicopathologic and Prognostic Significance of an Angiogenic Factor, Thymidine Phosphorylase, in Human Colorectal Carcinoma"
Authors: None Takebayashi
Journal: JNCI Journal of the National Cancer Institute (1996)

The first sentence of paragraph two of “Patients and Methods” should read, “Monoclonal antibodies were raised against a glutathione S-transferase (GST)-dThdPase fusion product containing 244 amino acids of dThdPase (amino acid residues 7-250).”
Endoscopic Management of Intra-Gastric Migration of an Esophageal Stent
Authors: M Oustani, A Zazour, A El Mekkaoui, W Khannoussi, G Kharrasse, Ismaili MZ
Journal: Endoscopy (2021)

A 78-years-old patient with a metastatic esophago-gastric junction moderately differentiated adenocarcinoma. He presents an aphagia with alteration of the general state. The biological evaluation was without abnormality. Upper gastrointestinal endoscopy showed a tumor stenosis of the lower esophagus that could not be passed. The fully covered esophageal stent was placed (the only one available). The X-ray control the next day showed that the stent had migrated intra-gastric. In this video, we show the technique of stent repositioning.
Reactogenicity, safety and antibody response, after one and two doses of mRNA-1273 in seronegative and seropositive healthcare workers
Authors: Marie Tré-Hardy, Roberto Cupaiolo, Emmanuelle Papleux, Alain Wilmet, Alexandra Horeanga, Thomas Antoine-Moussiaux, Andrea Della Vecchia, Ingrid Beukinga, Marc Vekemans, Laurent Blairon
Journal: Journal of Infection (2021)
Unexplained in-hospital fever following cardiac surgery. Natural history, relationship to postpericardiotomy syndrome, and a prospective study of therapy with indomethacin versus placebo.
Authors: F DLivelli, R AJohnson, M TMcEnany, ESherman, JNewell, P CBlock, R WDeSanctis
Journal: Circulation (1978)

In Part I of this study, the in-hospital course of 219 patients who had undergone a cardiac operation is analyzed. Fever (greater than or equal to 37.8 degrees C, rectal) was present after postoperative day 6 in 159 patients (73%) and was of unexplained cause in 118. Fever decay in the population of unexplained fever patients was exponential. All patients with unexplained postoperative fever were afebrile by postoperative day 19. In-hospital pericardial rub and pleuritic chest pain, widening of the mediastinum on chest film, and pleural effusion were not specifically associated with unexplained postoperative fever. In Part II, 67 patients with unexplained postoperative fever were given indomethacin (100 mg per day) or placebo for 7 days by a randomized, double-blind protocol. Indomethacin resulted in a shorter duration of fever (2.4 vs 3.5 days, P is less than 0.01) and in a shorter duration of chest pain, malaise, and myalgias compared to placebo. Sixty-seven percent of the patients in Part I and all of ...
Stereoselective interaction of sulfinpyrazone with racemic warfarin and its separated enantiomorphs in man.
Authors: R AO'Reilly
Journal: Circulation (1982)

Although serious hemorrhage during therapeutic coadministration of sulfinpyrazone and racemic warfarin occurs, no prospective studies have been done. In this study, single oral doses of racemic warfarin, 1.5 mg/kg, were administered to six normal subjects with and without oral sulfinpyrazone, 400 mg daily. Both the hypoprothrombinemia (p less than 0.001) and the plasma warfarin concentrations (p less than 0.05) were significantly augmented. To determine if this interaction was stereoselective, the experiments were repeated in the same subjects with R-and S-warfarin enantiomorphs. S-warfarin with sulfinpyrazone caused a highly significant augmentation of both the hypoprothrombinemia (p less than 0.001) and the plasma warfarin concentrations (p less than 0.001). R-warfarin with sulfinpyrazone did not significantly change the hypoprothrombinemia but significantly (p less than 0.05) reduced warfarin concentrations. Thus, sulfinpyrazone augmented the hypoprothrombinemia of racemic warfarin stereoselectively by...
Responses of angiographically normal human coronary arteries to intracoronary injection of acetylcholine by age and segment. Possible role of early coronary atherosclerosis.
Authors: HYasue, KMatsuyama, KOkumura, YMorikami, HOgawa
Journal: Circulation (1990)

We examined the response of left coronary arteries to intracoronary injection of acetylcholine (ACh) 50 micrograms in 74 patients by measuring the diameter changes with a videodensitometric analysis system. Patients with angiographically normal coronary arteries were subdivided into a younger group of 26 patients (age, 9-29 years) and an older group of 23 patients (age, 31-68 years). In the younger group, the diameter at the distal segment of the left anterior descending artery (LAD) and at the proximal, middle, and distal segments of the left circumflex artery (LCx) increased significantly (16.7 +/- 19.3%, p less than 0.01, for LAD and 8.0 +/- 18.8%, p less than 0.05; 11.0 +/- 16.1%, p less than 0.01; and 19.8 +/- 17.5%, p less than 0.01, for LCx segments, respectively) in response to ACh. In the older group, on the other hand, the diameter at the proximal and middle segments of LAD and LCx decreased significantly (-20.8 +/- 16.9%, p less than 0.01; and -17.9 +/- 28.4%, p less than 0.01, for LAD segments...
Dynamical trajectory of glucocorticoids tapering and discontinuation in patients with rheumatoid arthritis commencing glucocorticoids with csDMARDs: a real-world data from 2009 to 2020
Authors: Wenhui Xie, Hong Huang, Guangtao Li, Yanjie Hao, Yanni Gui, Yu Wang, Xuerong Deng, Juan Zhao, Yan Geng, LanLan Ji, Xiaohui Zhang, Zhibo Song, Zhuoli Zhang
Journal: Annals of the Rheumatic Diseases (2021)

Objective To unravel the dynamical trajectory and features of glucocorticoids (GC) tapering and discontinuation in patients with rheumatoid arthritis (RA) commencing GC with concomitant conventional synthetic disease-modifying antirheumatic drugs (csDMARDs). Methods We used data from longitudinal real-world Treat-to-TARget in RA cohort. Patients with RA who started GC and contaminant csDMARDs therapy were included. The changes in GC dose and disease activity were evaluated. GC discontinuation rate was analysed using Kaplan-Meier analysis. The relapse profile within 6 months after GC discontinuation was also analysed. Results A total of 207 patients with RA were included. During a median follow-up of 38.6 months, 124 patients discontinued GC. The median prednisolone dose of 10 (5–10) mg/day at initiation was reduced by 50% in the first 6 months and then more slowly, to zero by 48 months eventually. The cumulative probabilities of GC discontinuation were 9.7%, 26.6%, 48.0% and 58.6% at month 6, years 1, 2 and 3, with calculated median time to GC cessation of 27 months. In 110 DMARD-naïve patients, the corresponding cumulative probabilities of GC discontinuation were, respectively, 12.7%, 30.0%, 50.9% and 60.6%, with calculated median time to GC cessation of 24 months. Of the 124 patients who discontinued GC, adding other csDMARDs or concomitant csDMARDs increment was documented in 28.2% of them. Approximately half of 124 patients were in clinical remission at GC discontinuation. Within 6 months after GC withdrawal, 79.1% (91/115) of patients maintained relapse free. Conclusions In patients with RA commencing GC besides csDMARDs, GC is feasibly discontinued with favourable control of disease activity in real-life setting, mostly without short-term flare. But the withdrawal time is far from reaching the recommended time frame, indicating the gap between real-world practice and current guidelines.
Short- and long-term determinants of baroreceptor function in aged normotensive and spontaneously hypertensive rats.
Authors: M CAndresen
Journal: Circulation Research (1984)

In a variety of animal models, baroreceptor resetting during chronic hypertension has been correlated to vessel wall hypertrophy and decreased distensibility. In one possible mechanism of chronic resetting, termed the splinting hypothesis here, it has been suggested that a stiffer vessel wall might increase the minimum pressure required for activation of these mechanoreceptors (pressure threshold) and decrease suprathreshold pressure sensitivity. Lower vessel distensibility would alter baroreceptor function by preventing equivalent pressures from producing equivalent vessel distensions and, thus, receptor distortions. Recent studies have also suggested that the pressure threshold is strongly influenced by the most recent (minutes) history of blood pressure exposure during a process termed rapid resetting. Hypertension and advanced aging are associated with distensibility changes. The present study examines pressure and equivalent mechanical response characteristics of aortic baroreceptors from aged normot...
Role of the renin-angiotensin system in the systemic vasoconstriction of chronic congestive heart failure.
Authors: CCurtiss, J NCohn, TVrobel, J AFranciosa
Journal: Circulation (1978)

In 15 patients with severe chronic left ventricular failure, plasma renin activity (PRA) ranged widely, from 0.2--39 ng/ml/hr. The level of PRA was unrelated to cardiac output (CO) or pulmonary artery wedge pressure (PWP), but was slightly negatively correlated with mean arterial pressure (MAP) (r = -0.45) and systemic vascular resistance (SVR) (r = -0.40). After infusion of the angiotensin converting enzyme inhibitor teprotide (SQ 20,881) PWP fell from 26.3 +/- 1.3 (SEM) to 20.3 +/- 1.4 mm Hg (P less than 0.001), CO rose from 3.94 +/- 0.23 to 4.75 +/- 0.31 l/min (P less than 0.001), MAP fell from 87.5 +/- 3.8 to 77.9 +/- 4.1 mm Hg (P less than 0.001) and SVR from 1619 +/- 148 to 1252 +/- 137 dyne-sec-cm-5 (P less than 0.001). The fall in MAP and in SVR was significantly correlated with control PRA (r = 0.68 and r = 0.58, respectively). When subjects were divided on the basis of control PRA the hemodynamic response to teprotide was greatest in the high renin group. PRA rose after teprotide (8.7 +/- 3.4 to...
The effects of acetylstrophanthidin and ouabain on the sympathetic adrenergic neuroeffector junction in canine vascular smooth muscle.
Authors: R RLorenz, D APowis, P MVanhoutte, J TShepherd
Journal: Circulation Research (1980)

We performed experiments to determine the effects of acetylstrophanthidin (ACS) and ouabain on the adrenergic neuroeffector junction in dog saphenous veins. In quiescent strips incubated with 3H-norepinephrine (3H-NE), the drugs caused contraction and a progressive increase in overflow of 3H-NE and O-methylated metabolites; 3,4-dihydroxyphenylglycol (DOPEG) decreased. Tissue uptake of 3H-NE was partially inhibited. After surgical sympathectomy, both contraction and 3H-NE overflow were markedly attenuated. Following chemical sympathectomy with 6-hydroxydopamine, ouabain contractions were 11% of control, whereas the contractions due to exogenous norepinephrine were exaggerated. The initial overflow of 3H-NE was unaffected by tetrodotoxin, but the later and larger overflow with prolonged exposure was depressed. The former occurred in the absence of Ca2+, but the latter was Ca2+ dependent. Inhibition of the neuronal amine carrier by cocaine or desipramine and blockade of the neuronal alpha-adrenoceptors with ...
Dickkopf 1 impairs the tumor response to PD-1 blockade by inactivating CD8+ T cells in deficient mismatch repair colorectal cancer
Authors: Qiaoqi Sui, Dingxin Liu, Wu Jiang, Jinghua Tang, Lingheng Kong, Kai Han, Leen Liao, Yuan Li, Qingjian Ou, Binyi Xiao, Guochen Liu, Yihong Ling, Jiewei Chen, Zexian Liu, Zhixiang Zuo, Zhizhong Pan, Penghui Zhou, Jian Zheng, Pei-Rong Ding
Journal: Journal for ImmunoTherapy of Cancer (2021)

Dickkopf 1 (DKK1) is associated with tumor progression. However, whether DKK1 influences the tumor response to programmed cell death protein 1 (PD-1) blockade in colorectal cancers (CRCs) with deficient mismatch repair (dMMR) or microsatellite instability (MSI) has never been clarified.
Abstract 13723: Representation of Women and Older Patients in Trials of Lipid Lowering Therapy: A Systematic Review
Authors: Safi U Khan, Muhammad Z Khan, Haris Riaz, Charumathi Raghu Subramanian, Muhammad U Khan, Ahmad N Lone, Mohammad S Khan, Mohamad Adnan Alkhouli, Michael J Blaha, Roger S Blumenthal, Erin D Michos
Journal: Circulation (2019)

Introduction: Lipid lowering therapies are the cornerstone of the management of atherosclerotic cardiovascular disease (ASCVD). We sought to assess the temporal trend of women and older patients pa...
Ultra-High Magnification Endocytoscopy to Define Deep Endoscopic and Histologic Remission in Ulcerative Colitis
Authors: M Iacucci, OM Nardone, A Bazarova, L Jeffery, A Acharjee, SC Smith, UN Shivaji, R Cannatelli, G Gkoutos, S Ghosh
Journal: Endoscopy (2021)

Aims Increasingly both endoscopic remission (ER) and histological remission (HR) are targets of therapy in ulcerative colitis (UC). We aimed to define deep remission in patients with UC by assessing cellular architecture and the correlation with endoscopic scores by using ultra-high-magnification endocytoscopy (ECS) and histological indices.
Direct analysis of beta-adrenergic receptor subtypes on intact adult ventricular myocytes of the rat.
Authors: I LBuxton, L LBrunton
Journal: Circulation Research (1985)

beta 1- and beta 2-Adrenergic receptors co-exist in the adult rat ventricle. We have employed radioligand binding and cell purification techniques to determine the cellular origin of these receptors. The beta-adrenergic antagonist ligand (+/-)-[125I] iodocyanopindolol binds to 2 X 10(5) receptors per purified adult rat cardiomyocyte, with a dissociation constant of 70 pM. The subtype-selective antagonists betaxolol (beta 1), practolol (beta 1), and zinterol (beta 2) compete for [125I]iodocyanopindolol-binding sites on intact myocytes in monophasic manners with dissociation constants of 46, 845, and 923 nM, respectively. [125I]iodocyanopindolol binding to membranes prepared from nonmyocyte elements of rat ventricle occurs with a dissociation constant of 43 pM and a capacity of 88 fmol/mg membrane protein. Computer analysis of competition of [125I]iodocyanopindolol binding by betaxolol, practolol, and zinterol in nonmyocyte membranes demonstrates biphasic curves that comprise binding to both beta 1- and bet...
Reduction of coronary reserve: a mechanism for angina pectoris in patients with arterial hypertension and normal coronary arteries.
Authors: DOpherk, GMall, HZebe, FSchwarz, EWeihe, JManthey, WKübler
Journal: Circulation (1984)

The pathogenesis of angina pectoris in patients with left ventricular hypertrophy secondary to arterial hypertension and with normal coronary arteries remains uncertain. We measured coronary blood flow (argon method) in 12 control subjects and in 16 patients with arterial hypertension at rest and after intravenous administration of dipyridamole (0.5 mg/kg). In the patients with arterial hypertension, coronary blood flow response to dipyridamole was markedly reduced (p less than .001 as compared with control values). During coronary vasodilation there was a linear correlation between coronary resistance and left ventricular end-diastolic pressure (r = .67, p less than .001). Left ventricular catheter biopsy specimens did not reveal alterations in myocardial microvasculature. These findings suggest that reduction of coronary reserve may be an important contributor to the pathogenesis of angina pectoris in these patients.
Conduction over an isthmus of atrial myocardium in vivo: a possible model of Wolff-Parkinson-White syndrome.
Authors: HInoue, D PZipes
Journal: Circulation (1987)

Antiarrhythmic drugs appear preferentially to prolong refractoriness of accessory pathways compared with atrial or ventricular muscle in patients with the Wolff-Parkinson-White syndrome. This response may be due to intrinsic properties of accessory pathways or to depressed conduction associated with a narrow strip, or isthmus, of tissue. To test the latter possibility, in 16 anesthetized dogs we surgically isolated a portion of the right atrial myocardium in the form of an ellipse (10 to 25 X 8 to 15 mm). The ellipse was connected to the body of the right atrium by a narrow isthmus (cross-sectional area [CSA] 1 to 13.5 mm2) and was perfused by the sinus node artery or its branch. Diastolic threshold (mean +/- SE 0.16 +/- 0.05 vs 0.13 +/- 0.02 mA) and effective refractory period (ERP; 144 +/- 4 vs 139 +/- 5 msec) were the same proximal and distal to the isthmus. In eight dogs, determination of the ERP of the isthmus was limited by the ERP of the atrial tissue proximal and distal to the isthmus, and the CSA...
Asthma and risk of bronchiectasis exacerbation: we still need more evidence
Authors: Yong-hua Gao, Wei-jie Guan, Rong-chang Chen, Guo-jun Zhang
Journal: European Respiratory Journal (2016)

We have read with great interest the report by Mao et al. [1] investigating the effect of coexisting asthma on the risk of bronchiectasis exacerbation. The investigators reported that the risk of bronchiectasis exacerbation is increased in patients concomitant with asthma compared to those without, with an estimated odds ratio of 2.6 (95% CI 1.15–5.88). Other variables associated with this relationship included age, duration of symptoms, forced expiratory volume 1 s <50%, isolation of Pseudomonas aeruginosa in sputum and lung lesion extension to more than two lobes. Although these are exciting findings, there are some concerns we would like to address. Asthma and increased risk of bronchiectasis exacerbation should be interpreted with caution <http://ow.ly/ssIY300oQM9>
Highlights from a year in a pandemic
Authors: Miriam Merad, Nicolas Vabret
Journal: The Journal of Experimental Medicine (2021)

COVID-19 has emerged as one of the worst pandemics in recent history and has exposed the weaknesses of healthcare systems worldwide. Here, we reflect on the lessons learned from a year in a pandemic. We discuss the extraordinary scientific advances made in our understanding of a new disease, the failed and successful attempts to halt its progression, and the impact of the pandemic on the scientific discourse within the global community.
Confocal Laser Endomicroscopy In The Colonic Mucosa Of Patients With Diverticular Disease: Interim Results
Authors: C Robles-Medranda, R Oleas, M Puga-Tejada, J Alcivar-Vasquez, C Cifuentes, H Alvarado, R Del Valle, H Pitanga-Lukashok
Journal: Endoscopy (2021)

Aims We aimed to describe the role of peri-diverticular and colonic mucosal in patients with colonic diverticular disease using confocal laser endomicroscopy.