tbuckley/cabot-search huggingface dataset:
Lower Airway Dysbiosis Affects Lung Cancer Progression
Authors: Jun-Chieh J. Tsay, Benjamin G. Wu, Imran Sulaiman, Katherine Gershner, Rosemary Schluger, Yonghua Li, Ting-An Yie, Peter Meyn, Evan Olsen, Luisannay Perez, Brendan Franca, Joseph Carpenito, Tadasu Iizumi, Mariam El-Ashmawy, Michelle Badri, James T. Morton, Nan Shen, Linchen He, Gaetane Michaud, Samaan Rafeq, Jamie L. Bessich, Robert L. Smith, Harald Sauthoff, Kevin Felner, Ray Pillai, Anastasia-Maria Zavitsanou, Sergei B. Koralov, Valeria Mezzano, Cynthia A. Loomis, Andre L. Moreira, William Moore, Aristotelis Tsirigos, Adriana Heguy, William N. Rom, Daniel H. Sterman, Harvey I. Pass, Jose C. Clemente, Huilin Li, Richard Bonneau, Kwok-Kin Wong, Thales Papagiannakopoulos, Leopoldo N. Segal
Journal: Cancer Discovery (2020)

In lung cancer, enrichment of the lower airway microbiota with oral commensals commonly occurs, and
Learning to complete incomplete hearts for population analysis of cardiac MR images
Authors: Yan Xia, Nishant Ravikumar, Alejandro F. Frangi
Journal: Medical Image Analysis (2022)

Cardiac MR acquisition with complete coverage from base to apex is required to ensure accurate subsequent analyses, such as volumetric and functional measurements. However, this requirement cannot be guaranteed when acquiring images in the presence of motion induced by cardiac muscle contraction and respiration. To address this problem, we propose an effective two-stage pipeline for detecting and synthesising absent slices in both the apical and basal region. The detection model comprises several dense blocks containing convolutional long short-term memory (ConvLSTM) layers, to leverage through-plane contextual and sequential ordering information of slices in cine MR data and achieve reliable classification results. The imputation network is based on a dedicated conditional generative adversarial network (GAN) that helps retain key visual cues and fine structural details in the synthesised image slices. The proposed network can infer multiple missing slices that are anatomically plausible and lead to improved accuracy of subsequent analyses on cardiac MRIs, e.g., ventricle segmentation, cardiac quantification compared to those derived from incomplete cardiac MR datasets. For instance, the results obtained when compensating for the absence of two basal slices show that the mean differences to the reference of stroke volume and ejection fraction are only -1.3 mL and -1.0%, respectively, which are significantly smaller than those calculated from the incomplete data (-26.8 mL and -6.7%). The proposed approach can improve the reliability of high-throughput image analysis in large-scale population studies, minimising the need for re-scanning patients or discarding incomplete acquisitions.
Commentaire de travail de A. Fritscher-Ravens et al., pp. 29
Journal: Endoscopy (2009)

See also:Beyond NOTES: randomized controlled study of different methods of flexible endoscopic hemostasis of artificially induced hemorrhage, via NOTES access to the peritoneal cavityEndoscopy 2009; 41(01): 29-35DOI: 10.1055/s-0028-1103487
Abstract 235: GJA1-11k Localizes to the Nucleus and Inhibits Cell Cycle Progression
Authors: Irina Epifantseva, Shaohua Xiao, Nan Deng, TingTing Hong, Robin Shaw
Journal: Circulation Research (2017)

Gap Junction (GJ) channels, including the most common Connexin 43 (Cx43), are involved in the exchange of ions and small molecules to maintain homeostasis and also have fundamental roles in excitable tissues by facilitating rapid transmission of action potentials between adjacent cells. For instance, synchronization during each heartbeat is regulated by these ion channels at the cardiomyocyte cell-cell border. Numerous studies have found that Cx43 (predominantly the C-domain) is associated with control of cell proliferation, yet it is unclear how Cx43-based membrane channels effect these processes. We recently identified the existence of six endogenous Cx43 isoforms which are produced from the same full-length mRNA molecule in human cells by means of alternative translation and many of the known non-canonical roles of Cx43 can be attributed to these recently identified isoforms. Here we report that the smaller, non-channel related, alternatively translated isoform of Cx43 can directly affect cell growth. We found that 11KDa isoform (GJA1-11k) is localized in the nucleus of HEK293FT cells. GJA1-11k is a more potent growth suppressor than the wild type and full length isoform GJA1-43k. GJA1-11k-mediated growth suppression was achieved by limiting cell cycle progression from G0/G1 to S phase, in part, through regulation of internal translation of GJA1-11k. Nuclear localization experiments indicate that the cell growth-suppressive properties of GJA1-11k is linked to nuclear activity. RNA-seq based genome-wide mRNA transcriptome analysis revealed that the heat shock protein HSPA6, which is normally upregulated in certain cancer cells, was significantly downregulated in GJA1-11k overexpressing cells compared to cells overexpressing the full length isoform, suggesting a potential mechanism and/or new binding protein for the Cx43 C-terminal domain. In general, further understanding of the role of small Cx43 isoforms will provide a way not only to understand the mechanism controlling myocyte proliferation to improve the repair of the myocardium, but also to understand the pathobiology of cell growth associated with tumor suppressive properties of Cx43. It may be possible to develop new therapeutics by regulating alternative translation of Cx43.
ACCF/AHA/AMA-PCPI 2011 Performance Measures for Adults With Heart Failure
Authors: Robert O. Bonow, Theodore G. Ganiats, Craig T. Beam, Kathleen Blake, Donald E. Casey, Sarah J. Goodlin, Kathleen L. Grady, Randal F. Hundley, Mariell Jessup, Thomas E. Lynn, Frederick A. Masoudi, David Nilasena, Ileana L. Piña, Paul D. Rockswold, Lawrence B. Sadwin, Joanna D. Sikkema, Carrie A. Sincak, John Spertus, Patrick J. Torcson, Elizabeth Torres, Mark V. Williams, John B. Wong
Journal: Journal of the American College of Cardiology (2012)
Septal ablation for hypertropic obstructive cardiomyopathy: An analysis of the patients with dissatisfactory reduction of the outflow gradient Lothar Faber, Bernd Werlemann, Leon Krater, Hubert Seggewiss, Dieter Hortskotte, Heart Center North Rhine-Westphalia, Bad Oeynhausen, Germany, Leopoldina Hospital, Schweinfurt, Germany
Journal: Journal of the American College of Cardiology (2001)
New and Nonofficial Remedies
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Department of Error
Authors: Toby Richards, Ben Clevenger, Darren Dahly, Martin Besser
Journal: The Lancet (2021)

Routine testing of anaemia, inves tigation of causality, and directed therapy should be standard medical care for all patients with anaemia, not just those undergoing surgery.However, our PREVENTT trial 1 high lights a need to better define iron deficiency.There is great variation in existing guidelines for diagnosing absolute or functional iron deficiency, inflammatory anaemia, and anaemia of chronic disease. 5Further work is needed to define iron deficiency that possibly responds to iron supplementation or anaemia of chronic disease that might respond to combination therapy.A significant increase in haemo globin concentrations was seen after surgery with supplementation of intravenous iron that might represent a better erythrogenic response to blood loss, which was associated with the novel finding of reduced readmissions to hospital for complications (including infection) and requires further inves tigation.
Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation Effect on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure
Authors: Stephen Derdak
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sharing Clinical Trial Data — A Proposal from the International Committee of Medical Journal Editors
Authors: Darren B. Taichman, Joyce Backus, Christopher Baethge, Howard Bauchner, Peter W. de Leeuw, Jeffrey M. Drazen, John Fletcher, Frank A. Frizelle, Trish Groves, Abraham Haileamlak, Astrid James, Christine Laine, Larry Peiperl, Anja Pinborg, Peush Sahni, Sinan Wu
Journal: New England Journal of Medicine (2016)
Local analgesia.
Authors: Leonard Bachman
Journal: JAMA (1963)

The use of local anesthesia is not confined to the specialist in anesthesia, but is an important part of the practice of many other specialists, the general physician, and the dentist. Its successful application requires a knowledgeable technique on the part of the operator. While there have been excellent but exhaustive volumes written on nerve-blocking, there still remained a need for a brief manual of the commonly-used nerve blocks. Clive Jolly, consultant anesthetist to the Ipswich Group of Hospitals, meets this need in a little over 100 pages. The volume consists of some general comments about nerve block technique, a practical brief pharmacology of the local anesthetics, and descriptions of nerve blocks for every part of the human body. A chapter is devoted to spinal and epidural anesthesia and finally some material on the use of therapeutic nerve block. Black-and-white line drawings accompany some of the nerve block techniques. The
843-6 Three-year follow-up of the RAVEL study: A randomized study with the sirolimus-elutin gBx VELOCITY™ stent in the treatment of patients with de novo native coronary artery lesions
Authors: Marie-Claude Morice, Patrick Serruys, Costantino Constantini, Egon Wuelfert, William Wijns, Jean Fajadet, Antonio Colombo, Giulio Guagliumi, Ferenc Molnar, Ernesto Ban Hayashi, J.Eduardo Sousa, Marco Perin
Journal: Journal of the American College of Cardiology (2004)
SATIRE
Authors: P. Ciaglia
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Safety and efficacy of unfractionated heparin (UH) versus enoxaparin (E) in obese patients and patients with renal impairment: Analysis from ESSENCE and TIMI 11B studies Stephanie M. Inverso, Marc Cohen, Elliott M. Antman, Sarah A. Spinler, for the ESSENCE and TIMI 11B Investigators. Philadelphia College of Pharmacy at the University of the Sciences in Philadelphia, Philadelphia, PA
Journal: Journal of the American College of Cardiology (2001)
Identification of pregnancy-associated plasma protein A (PAPP-A) as a new marker of acute coronary syndromes Antonio Bayes-Genis, Cheryl A. Conover, Michael Christiansen, Dieter Lubbe, Claus Oxvig, John D. Altman, Michael T. Overgaard, Paul C. Keelan, Birgit Kantor, David R. Holmes, Jr., Robert S. Schwartz. Mayo Clinic, Rochester, MN
Journal: Journal of the American College of Cardiology (2001)
Its not all about sprinting: mechanisms of acute hamstring strain injuries in professional male rugby union—a systematic visual video analysis
Authors: Fearghal Kerin, Garreth Farrell, Peter Tierney, Ulrik McCarthy Persson, Giuseppe De Vito, Eamonn Delahunt
Journal: British Journal of Sports Medicine (2022)

Objectives The mechanisms of hamstring strain injuries (HSIs) in professional Rugby Union are not well understood. The aim of this study was to describe the mechanisms of HSIs in male professional Rugby Union players using video analysis. Methods All time-loss acute HSIs identified via retrospective analysis of the Leinster Rugby injury surveillance database across the 2015/2016 to 2017/2018 seasons were considered as potentially eligible for inclusion. Three chartered physiotherapists (analysts) independently assessed all videos with a consensus meeting convened to describe the injury mechanisms. The determination of the injury mechanisms was based on an inductive process informed by a critical review of HSI mechanism literature (including kinematics, kinetics and muscle activity). One of the analysts also developed a qualitative description of each injury mechanism. Results Seventeen acute HSIs were included in this study. Twelve per cent of the injuries were sustained during training with the remainder sustained during match-play. One HSI occurred due to direct contact to the injured muscle. The remainder were classified as indirect contact (ie, contact to another body region) or non-contact. These HSIs were sustained during five distinct actions—‘running’ (47%), ‘decelerating’ (18%), ‘kicking’ (6%), during a ‘tackle’ (6%) and ‘rucking’ (18%). The most common biomechanical presentation of the injured limb was characterised by trunk flexion with concomitant active knee extension (76%). Fifty per cent of cases also involved ipsilateral trunk rotation. Conclusion HSIs in this study of Rugby Union were sustained during a number of playing situations and not just during sprinting. We identified a number of injury mechanisms including: ‘running’, ‘decelerating’, ‘kicking’, ‘tackle’, ‘rucking’ and ‘direct trauma’. Hamstring muscle lengthening, characterised by trunk flexion and relative knee extension, appears to be a fundamental characteristic of the mechanisms of acute HSIs in Rugby Union.
Abstract P155: Risk for Recurrent Events Among Patients Receiving Intensive Medical Management Following Myocardial Infarction
Authors: Lisandro D Colantonio, Todd M Brown, Vera A Bittner, Hong Zhao, Michael E Farkouh, Keri L Monda, Robert S Rosenson, Ransi M Somaratne, Mark Woodward, Paul Muntner
Journal: Circulation (2018)

Background: Randomized trials have shown that several medications reduce the risk for recurrent coronary heart disease (CHD) events following myocardial infarction (MI). Knowing the risk for recurrent events among patients receiving intensive medical management following MI can inform patient-physician shared decision making. Objective: To estimate the risk for CHD events among patients receiving intensive medical management following an MI hospitalization. Methods: We identified US adults 18-64 years with commercial health insurance in Marketscan who had an MI hospitalization (defined by an ICD-9 code of 410.x0 or 410.x1 in the primary discharge diagnosis position) in 2014-2015. Intensive medical management was defined as filling a high-intensity statin, renin-angiotensin system inhibitor, beta-blocker and antiplatelet agent within 30 days following hospital discharge for MI. Patients receiving intensive medical management were matched 1:2 by age, sex and calendar year to randomly selected controls from the general population and followed for recurrent MI and CHD events (i.e., MI or coronary revascularization). Results: Among MI patients (n=17,643, mean age 55 years, 74% male), 29.6% received intensive medical management. After adjustment for comorbid conditions, intensive medical management was more common among men (relative risk [95% CI] 1.14 [1.07, 1.20]), those who received a stent during their MI hospitalization (2.54 [2.37, 2.73]) and those who received cardiologist care (1.17 [1.11, 1.22]) and cardiac rehabilitation (1.14 [1.08, 1.20]) after hospital discharge. The risk for recurrent MI and CHD events was higher among MI patients receiving intensive medical management compared to controls, overall and when restricted to MI patients with high medication adherence ( Table ). Conclusion: MI patients receiving intensive medical management have a substantial residual risk for recurrent CHD events.
Author Correction
Journal: Journal of Clinical Oncology (2013)

contained an error.The legend of Figure 1 was given as: "If the PSA at time point no. 3 (value no.3A) is greater than at time point no.2, then the requirement for a sequence of three increases has been met."Whereas it should have been:"If the PSA at time point no. 3 (value no.3A) is greater than at time point no.2, then the requirement for a sequence of two increases has been met.
Analysis of survival trends, clinical, and molecular characteristics of patients with early-onset colorectal cancer (EOCRC).
Authors: Javier Soto, Natalia Gutiérrez Alonso, Marianela Bringas Beranek, Juan Luis Catoya Villa, Ana Gutierrez Ortiz de la Tabla, Carlos López Jiménez, Manuel Alva Bianchi, Roberto Jiménez Rodríguez, Rocío Martín Lozano, Marta Arregui Valles, Inmaculada Aparicio Salcedo, Laura Ortega Morán, Gabriela Torres Pérez-Solero, Andrés J. Muñoz Martín, Aitana Calvo Ferrándiz, Montserrat Blanco Codesido, Íñigo Martínez Delfrade, David Salomon Juliao Caamaño, Miguel Martin, Pilar Garcia-Alfonso
Journal: Journal of Clinical Oncology (2022)

59 Background: Over the last decades the incidence of EOCRC (age 50 or less) has dramatically increased, and so has the scientific interest in this field, given that clinical and molecular characteristics in these patients are not well understood, and may be critical to identify prognostic factors. Methods: We conducted a retrospective analysis of 554 patients with metastatic colorectal cancer (mCRC), analyzing the PFS and OS of 68 (12.25%) patients with EOCRC, as well as their clinical and molecular characteristics. We used a log-rank test to compare PFS and OS, and the estimate of hazard ratio (HR) between the studied groups was calculated by means of Cox proportional hazard model. We also used the exact test of Fisher to identify significant association between categoric variants, while Mann-Whitney test was applied to identify significant differences between numeric values. Results: We performed a survival analysis: those patients with EOCRC had significantly higher median PFS in first line of treatment (16.2 vs. 11.3 months, p = 0.042) and significantly higher median OS (121.5 vs. 58.1 months, p = 0.011). Several characteristics were significantly more frequent in patients with EOCRC (n=68): BMI &lt; 18.5 (n = 16, OR = 1.9, p = 0.046), primary tumor site at transverse colon (n = 9, OR = 2.61, p = 0.03) and ECOG 0 (n = 32, OR = 2.21, p = 0.003). Having peritoneal metastases almost reached statistical signification (n = 17, OR = 1.82, p = 0.055). Some other characteristics were less frequent: BMI 25-30 (n = 13, OR = 0.51, p = 0.046), primary tumor site at sigmoid colon (n = 14, OR = 0.49, p = 0.038) and former-smoker status (n = 7, OR = 0.44, p = 0.048). Moreover, mean values of LDH at diagnosis were significantly higher in EOCRC patients (359 U/L vs. 280 U/L, p = 0.015). EOCRC patients received a significantly higher number of lines of chemotherapy (2.94 vs. 2.38, p = 0.027) and underwent more surgeries (2,42 vs. 1.24, p &lt; 0,001) than patients with &gt; 50 years. Significant differences in tumor mutational status (BRAF, KRAS, NRAS, MSI, PI3K and HER2), sex, primary tumor resection or number of metastatic sites between groups were not found. Conclusions: This retrospective analysis showed that EOCRC patients had significant higher rates of PFS in first-line treatment and OS. Moreover, EOCRC patients had more frequently BMI &lt; 18.5, primary tumor located at transverse colon and ECOG 0.
THE CALIFORNIA HORROR—AN APPEAL.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Angiographic patency of LIMA-LAD anastomosis after MIDCAB compared to conventional CABG: Results from the POEM trial Roxana Mehran, Valavanaur Subramanian, Michael Mack, Albert Pfister, Paul Corso, Inderjit S. Gill, E. Charles Douville, Trey Brunsting, James Magovern, Robert Matheny, Jeffrey W. Moses, Martin B. Leon. Lenox Hill Heart and Vascular Institute, New York, NY, Columbia Hospital and Medical Center, Dallas, TX
Journal: Journal of the American College of Cardiology (2001)