tbuckley/cabot-search huggingface dataset:
Coeliac disease in primary care: case finding study
Journal: BMJ (1999)

Objectives To provide evidence of underdiagnosis of coeliac disease and to describe the main presenting symptoms of coeliac disease in primary care.Design Case finding in a primary care setting by testing for coeliac disease by using the endomysial antibody test.Setting Nine surgeries in and around a market town in central England, serving a population of 70 000.Participants First 1000 patients screened from October 1996 to October 1997.Outcome measures Determination of endomysial antibody titre of patients fulfilling the study criteria, followed by small intestine biopsy of those with positive results. ResultsThe 30 patients (out of 1000 samples) with positive results on the endomysial antibody test all had histological confirmation on small intestine biopsy.The commonest mode of presentation (15/30) was anaemia of varying severity.Most patients (25/30) presented with non-gastrointestinal symptoms.Specificity of the endomysial antibody test was 30/30.Conclusions Underdiagnosis and misdiagnosis of coeliac disease are common in general practice and often result in protracted and unnecessary morbidity.Serological screening in primary care will uncover a large proportion of patients with this condition and should be made widely available and publicised.Coeliac disease should be considered in patients who have anaemia or are tired all the time, especially when there is a family history of the disease.
Clofarabine Plus Low-Dose Cytarabine for the Treatment of Patients with Higher-Risk Myelodysplastic Syndromes (MDS) Who Have Relapsed or Are Refractory to Hypomethylating Agent (HMA) Therapy
Authors: Elias Jabbour, Koji Sasaki, Naval Daver, Naveen Pemmaraju, Nitin Jain, Tapan M. Kadia, Courtney D. DiNardo, Gautam Borthakur, Marina Konopleva, Stefan H. Faderl, Susan O'Brien, Jorge Cortes, Hagop Kantarjian, Guillermo Garcia-Manero
Journal: Blood (2014)
BATF promotes group 2 innate lymphoid cell–mediated lung tissue protection during acute respiratory virus infection
Authors: Xiaopeng Wu, Moujtaba Y. Kasmani, Shikan Zheng, Achia Khatun, Yao Chen, Wendy Winkler, Ryan Zander, Robert Burns, Elizabeth J. Taparowsky, Jie Sun, Weiguo Cui
Journal: Science Immunology (2022)

BATF regulates ILC2-mediated tissue repair and inflammation resolution during acute respiratory virus infection.
THE SHAPES OF CELLS
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Cholera Epidemic of 1892 in the Russian Empire; With Notes upon Treatment and Methods of Disinfection in Cholera, and a Short Account of the Conference on Cholera held in St. Petersburg in December, 1892.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Is alternate day dosing of atorvastatin effective in managing patients with hyperlipidemia? The alternate day versus daily dosing of atorvastatin study (ADDAS) Mazen S. Matalka, Marcus C. Ravnan, Prakash C. Deedwania. VA Central California Health Care System, Fresno, CA, UCSF School of Medicine, San Francisco, CA
Journal: Journal of the American College of Cardiology (2001)
Skin Biopsy
Authors: Philip C. Anderson
Journal: JAMA (1967)

With the exception of blood, no human living tissue can be secured more easily or safely for cytologic study than can skin.<sup>1-5</sup>Our problem becomes then not how to biopsy the skin, but where, when, and why to biopsy, and, most important, what useful information we can expect from the pathologist's report. <h3>How.—</h3> The decision to biopsy made, a surgical tray is assembled containing a scalpel with a No. 15 blade, fine surgical pickups, appropriate 4-0 or 5-0 silk or nylon suture with the needle attached, a small needle holder, and six to a dozen 4 × 4-inch surgical sponges. Available in separate sterile packages are curved mosquito hemostats, which are used mainly for dissection because hemostasis of the biopsy wound generally can be secured by steady gentle pressure for three minutes by the clock. Skin punches of various sizes, small skin hooks, and an iris scissors are useful
Myocardial Rev-erb–Mediated Diurnal Metabolic Rhythm and Obesity Paradox
Authors: Shiyang Song, Chih-Liang Tien, Hao Cui, Paul Basil, Ningxia Zhu, Yingyun Gong, Wenbo Li, Hui Li, Qiying Fan, Jong Min Choi, Weijia Luo, Yanfeng Xue, Rui Cao, Wenjun Zhou, Andrea R. Ortiz, Brittany Stork, Vatsala Mundra, Nagireddy Putluri, Brian York, Maoping Chu, Jiang Chang, Sung Yun Jung, Liang Xie, Jiangping Song, Lilei Zhang, Zheng Sun
Journal: Circulation (2022)

The nuclear receptor Rev-erbα/β, a key component of the circadian clock, emerges as a drug target for heart diseases, but the function of cardiac Rev-erb has not been studied in vivo. Circadian disruption is implicated in heart diseases, but it is unknown whether cardiac molecular clock dysfunction is associated with the progression of any naturally occurring human heart diseases. Obesity paradox refers to the seemingly protective role of obesity for heart failure, but the mechanism is unclear.
Foundational assumption reasonable but uncertain
Authors: Rex A. Wright, Christopher Mlynski
Journal: Behavioral and Brain Sciences (2021)

Abstract We offer thoughts on Shadmehr and Ahmed's foundational assumption that behavioral intensity (vigor) is proportional to the perceived value of outcomes driving behavior (incentives). The assumption is reasonable considering classical motivational thought and scholarship in related literatures but called into question by an influential contemporary theory of motivation by Brehm. Brehm's theory suggests that the assumption is warranted in some, but not all, performance circumstances. Furthermore, proportionality between vigor and value might be generated through a deliberative goal-setting process rather than through intrinsic neural linkages.
Breast Cancer in Men
Journal: Annals of Internal Medicine (2002)

Summaries for Patients15 October 2002Breast Cancer in MenSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-8-200210150-00005 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Men can get breast cancer, but it is much less common in men than in women. Because breast cancer in men is rare, we know little about the factors that make men susceptible to the disease and how to treat it.Why did the authors do this review?The authors published a review of breast cancer in men in 1992. The purpose of the current review is to see whether material published in the past 10 years helps us reach new conclusions about breast cancer in men.How ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Breast Cancer in Men.” It is in the 15 October 2002 issue of Annals of Internal Medicine (volume 137, pages 678-687. The authors are SH Giordano, AU Buzdar, and GN Hortobagyi.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. Previousarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoBreast Cancer in Men Sharon H. Giordano , Aman U. Buzdar , and Gabriel N. Hortobagyi Metrics Cited byDelayed presentation, diagnosis, and psychosocial aspects of male breast cancer 15 October 2002Volume 137, Issue 8Page: I-63KeywordsBreast cancerCellsDatabasesEstrogensGrowth hormoneHemorrhageHormonesMedical risk factorsProgesteroneProteins ePublished: 15 October 2002 Issue Published: 15 October 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Queries and Minor Notes
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cases from Private Practice
Authors: J. R. Wardell
Journal: BMJ (1848)

dark carbonaceous colour, and gretly diminished in stze; biddear empty afrdarcted.It is my opinion that, owing to the distended state of the lower part of the colon and rectum, life wa pro.bervea, and the fat4l 6vent protracted, from the strong mechanical occlusion of the morbid opening, by the, ihid rted fects, preventing thereby ftcal effusion into th abdomiual caity.
Lymphomatoid Granulomatosis
Authors: Jack G. Rabinowitz
Journal: JAMA (1985)

LYMPHOMATOID granulomatosis (LYG) is a disease entity that shares clinical and histological features with several lesions that affect the lung. The basic histological characteristics of these lesions consist of a combination of granulomatosis and destructive angiitis.<sup>1,2</sup>Our experience with six patients with this entity afforded the opportunity to study the radiological changes and to compare them with those previously described in the literature, as well as with the other granulomatous lesions in this category. The diagnosis of LYG in our cases was confirmed by open-lung biopsy. <h3>Radiological Features</h3> Although the pulmonary manifestations of LYG have been described as fluctuating in presentation and appearance, a few findings in our patients appeared consistent and characteristic. In general, the most typical presentation of LYG consists of a bilateral distribution of multiple nodular densities that tend to favor the basilar pulmonary segments (Figs 1 and 2).<sup>3</sup>Five of our six patients as
Addition of Nonauthor Collaborator Names of the COVID-19 Lombardy ICU Network
Authors: Ashley Hirai, Jean Ko, Stephen Patrick
Journal: JAMA (2021)

Giacomo Grasselli, MD; Alberto Zangrillo, MD; Alberto Zanella, MD; Massimo Antonelli, MD; Luca Cabrini, MD; Antonio Castelli, MD; Danilo Cereda, MD; Antonio Coluccello, MD; Giuseppe Foti, MD; Roberto Fumagalli, MD; Giorgio Iotti, MD; Nicola Latronico, MD; Luca Lorini, MD; Stefano Merler, MS; Giuseppe Natalini, MD; Alessandra Piatti, MD; Marco Vito Ranieri, MD; Anna Mara Scandroglio, MD; Enrico Storti, MD; Maurizio Cecconi, MD; Antonio Pesenti, MD; COVID-19 Lombardy ICU Network; Emiliano Agosteo; Valentina Alaimo; Giovanni Albano; Andrea Albertin; Armando Alborghetti; Giorgio Aldegheri; Benvenuto Antonini; Enrico Barbara; Nicolangela Belgiorno; Mirko Belliato; Annalisa Benini; Enrico Beretta; Leonardo Bianciardi; Stefano Bonazzi; Massimo Borelli; Enrico Boselli; Nicola Bronzini; Carlo Capra; Livio Carnevale; Giampaolo Casella; Gianpaolo Castelli; Emanuele Catena; Sergio Cattaneo; Davide Chiumello; Silvia Cirri; Giuseppe Citerio; Sergio Colombo; Davide Coppini; Alberto Corona; Paolo Cortellazzi; Elena Costantini; Remo Daniel Covello; Gianluca De Filippi; Marco Dei Poli; Federica Della Mura; Giulia Evasi; Raquel Fernandez-Olmos; Andrea Forastieri Molinari; Marco Galletti; Giorgio Gallioli; Marco Gemma; Paolo Gnesin; Lorenzo Grazioli; Stefano Greco; Paolo Gritti; Paolo Grosso; Luca Guatteri; Davide Guzzon; Fabiola Harizay; Roberto Keim; Giovanni Landoni; Thomas Langer; Andrea Lombardo; Annalisa Malara; Elena Malpetti; Francesco Marino; Giovanni Marino; Maurizio Giovanni Mazzoni; Guido Merli; Antonio Micucci; Francesco Mojoli; Stefano Muttini; Adriana Nailescu; Mauro Panigada; Paolo Perazzo; Giovanni Battista Perego; Nicola Petrucci; Angelo Pezzi; Alessandro Protti; Danilo Radrizzani; Maurizio Raimondi; Marco Ranucci; Frank Rasulo; Mario Riccio; Roberto Rona; Claudio Roscitano; Patrizia Ruggeri; Antonello Sala; Giuseppe Sala; Luca Salvi; Pietro Sebastiano; Paolo Severgnini; Ilaria Sforzini; Francesco Donato Sigurtà; Matteo Subert; Paola Tagliabue; Carmine Troiano; Roberto Valsecchi; Uberto Viola; Giovanni Vitale; Massimo Zambon; Elena Zoia
Effect of antibiotic pretreatment on bacterial engraftment after Fecal Microbiota Transplant (FMT) in IBS-D
Authors: Prashant Singh, Eric J Alm, John M. Kelley, Vivian Cheng, Mark Smith, Zain Kassam, Judy Nee, Johanna Iturrino, Anthony Lembo
Journal: Gut Microbes (2022)

Fecal microbiota transplantation (FMT) is an attractive strategy to correct microbial dysbiosis in diarrhea-predominant irritable bowel syndrome (IBS-D). Although the mechanism of FMT is thought to be bacterial engraftment, the best approach to achieve engraftment after FMT in IBS-D (and other diseases) is not clear. We evaluated the effect of FMT (with or without pretreatment with antibiotics) on gut microbiome and symptoms in patients with IBS-D. In this randomized, placebo-controlled, single-center study, 44 patients with IBS-D with a least moderate severity (IBS severity scoring system, i.e., IBS-SSS, ≥175) were randomly assigned to one of four groups: single-dose oral FMT alone, single-dose oral FMT following a 7-day pretreatment course of Ciprofloxacin and Metronidazole (CM-FMT) or Rifaximin (R-FMT), or Placebo FMT. Primary endpoint was engraftment post-FMT and secondary endpoints were changes in IBS-SSS, and IBS-quality of life (IBS-QOL) at week 10. Median engraftment was significantly different among the three FMT groups (P = .013). Engraftment post-FMT was significantly higher in the FMT alone arm (15.5%) compared to that in R-FMT group (5%, P = .04) and CM-FMT group (2.4%, P = .002). The mean change in IBS-SSS and IBS-QOL from baseline were not significantly different among the four groups or between the three FMT groups combined vs. placebo at week 10. In summary, antibiotic pretreatment significantly reduced bacterial engraftment after FMT in patients with IBS-D.
Heberden Society: Annual Report, 1949-50
Journal: Annals of the Rheumatic Diseases (1950)

In presenting the 13th annual report of the Empire Rheumatism Council, the Chairman, Lord Horder, described the work of the Council during 1948 to 1949 under the headings of research, education, and relations abroad.In the field of research, he mentioned the investigation into the causes of rheumatoid arthritis begun in 1946 and recently ended.The data have been dealt with by the Council's statistician, Dr. Lewis-Faning, and the report is to be published as a special supplement to the Annals of the Rheumatic Diseases.Another inquiry by Dr. Maunsell into the relation of allergy to rheumatoid arthritis has revealed that there is no significant difference in allergic tendency between patients with rheumatoid arthritis and controls, but that where allergy exists in the former the incidence of infection is higher.An experimental study has shown that the permeability of arthritic joints is increased.The keen interest of the Council in developments related to cortisone treatment was stressed.Among the educational efforts of the Council the well-attended lecture courses for practitioners held at Apothecaries' Hall, and the lecture conferences arranged for hospital staff in various parts of the country were referred to.
Extranodal extension influences prognosis in pancreatic head cancer.
Authors: Min Kyu Sung, Guisuk Park, Seo Young Park, Woohyung Lee, Ki Byung Song, Jae Hoon Lee, Song Cheol Kim, Dae Wook Hwang, Seung Mo Hong
Journal: Journal of Clinical Oncology (2022)

593 Background: Extranodal extension (ENE) is an established prognostic factor of several gastrointestinal cancers; furthermore, ENE is already included as one component of nodal category of oral cavity, penis, and vulvar cancers. However, the prognostic impact of ENE in pancreatic cancer remains unclear. In this study, we aimed to investigate prognostic implication of ENE in patients with surgically resected pancreatic cancer. Methods: We retrospectively reviewed electronic medical records and pathologic slides of 503 surgically resected pancreatic head cancer patients, who consecutively underwent pancreaticoduodenectomy for pathologically confirmed pancreatic ductal adenocarcinoma between January 2009 and December 2013. Patients were categorized into subgroups according to ENE status and AJCC 8 th pancreatic cancer staging system. We compared the disease-free survival rates of the patients according to ENE status. Cox proportional hazard analysis was performed to evaluate prognostic factors for the disease-free survival of pancreatic head cancer. Results: ENE-positive patient group showed a larger tumor size, a higher rate of lymph node metastasis, and a tendency to be positive for lymphovascular invasion, perineural invasion, and resection margin (p &lt; 0.001). Patients with ENE had lower overall survival (OS) and disease-free survival (DFS) rates compared with those without ENE (N0, 30 months; LN+/ENE-, 20 months; LN+/ENE+, 16 months; p &lt; 0.001), (N0, 13 months; LN+/ENE-, 8 months; LN+/ENE+, 5 months; p &lt; 0.001). Patients with higher N categories had lower OS and DFS rates. In addition, even in the same N stage, patients with ENE showed lower OS and DFS rates than those without ENE (p &lt; 0.001). However, there was no significant difference in survival rates between patients in the N1/ENE+ group and the N2/ENE- group. Additionally, ENE was an independent prognostic factor for pancreatic cancer. Conclusions: ENE significantly influenced adverse prognosis among patients with pancreatic head cancer especially for those with nodal metastasis. Therefore, ENE should be considered as a prognostic factor in the future editions of the AJCC staging system.
Elevated C-reactive protein levels on admission are related to ST segment elevation resolution in patients with acute myocardial infarction Michael Zairis, Stavros Manousakis, Alexander Stefanidis, Denis Vitalis, George Andrikopoulos, Stelios Handanis, Kostas Katsaros, John Hadjissavas, Spyros Argyrakis, Panayiotis Asimakopoulos, Stefanos Foussas. Cardiology Department, Tzanio Hospital, Piraeus, Greece
Journal: Journal of the American College of Cardiology (2001)
FORMALDEHYDE DISINFECTION.
Authors: WM. R. STOKES
Journal: JAMA (1898)

Although formaldehyde was first obtained by von Hoffman in 1866, who made it by passing the vapor of wood alcohol over finely divided platinum, yet its practical use as a disinfectant was not applied until quite recently. Aronson<sup>1</sup>published the results of some work in 1892, showing that formaldehyde gas would destroy pathogenic bacteria, even when these organisms were exposed superficially in large rooms. Under such circumstances he found that when such bacteria as the staphylococcus pyogenes aureus, the streptococcus, the bacillus pyocyaneus, the typhoid bacillus, the diphtheria bacillus, the anthrax bacillus and the tubercle bacillus were exposed to the action of the gas in sufficient concentration, these germs were destroyed. Sterilized pieces of silk thread, gauze, linen and wool were soaked in bouillon cultures of these organisms and then placed in various portions of the room. Cultures from these materials which had been exposed to the gas remained