tbuckley/cabot-search huggingface dataset:
Endoscopic transmural route for dissection of gastric submucosal tumors with extraluminal growth: experience in two cases
Authors: Xinyang Liu, Tianyin Chen, Jing Cheng, Pingting Gao, Quanlin Li, Weifeng Chen, Yiqun Zhang, Pinghong Zhou, Jianwei Hu
Journal: Gut (2021)

The spectrum of endoscopic resection methods, including full thickness techniques, has enabled removal of most smaller gastric submucosal tumours (SMTs). We developed an extended transmural endoscopic dissection technique for lesions with predominately extraluminal growth arising from the muscularis propria. It consists of transmural intraperitoneal access with the endoscope besides the lesion followed by subserosal dissection from the outside. The technique was successful in two patients with smaller (2–3 cm) gastric stromal tumours; lesions were resected completely and short-term follow-up was normal. Further studies are warranted to confirm the safety and feasibility of this this new approach.

With the popularisation of endoscopy and the development of endoscopic ultrasonography (EUS), the detection rate of gastrointestinal (GI) SMT has increased significantly.1 Complete surgical resection is still recognised as the primary and the most important way to treat gastric SMT and to get clear pathological diagnosis.2 Minimally invasive endoscopic therapy received increasing recognition due to its advantages of less invasiveness, fewer complications, quicker recovery and lower costs compared with open surgery or laparoscopic surgery. Gastric SMTs derived from mucosal and submucosal layers could be resected by endoscopic mucosal resection and endoscopic submucosal dissection, while those originated from deep layers of the gastric wall can be resected using endoscopic full-thickness resection (EFTR), which intentionally perforates the gastric wall to achieve complete resection.3 With an increasing emphasis on protecting the intact of mucosa, endoscopic mucosa-sparing lateral dissection was developed to reduce the postoperative complications.4 Inspired by the submucosal tunnelling endoscopic resection (STER)5 technique, in which maintenance of mucosal integrity and the longitudinal submucosal tunnel lead to rapid healing and decreased risk of pleural infection, STER for extraluminal tumours was reported for resection of SMTs with a predominant extraluminal growth pattern or extra-GI tumours.6 However, for most SMTs with a predominately extraluminal …
Combined inhibition of Aurora-A and ATR kinases results in regression of MYCN-amplified neuroblastoma
Authors: Isabelle Roeschert, Evon Poon, Anton G. Henssen, Heathcliff Dorado Garcia, Marco Gatti, Celeste Giansanti, Yann Jamin, Carsten P. Ade, Peter Gallant, Christina Schülein-Völk, Petra Beli, Mark Richards, Mathias Rosenfeldt, Matthias Altmeyer, John Anderson, Angelika Eggert, Matthias Dobbelstein, Richard Bayliss, Louis Chesler, Gabriele Büchel, Martin Eilers
Journal: Nature Cancer (2021)
Masked Hypertension and White-Coat Hypertension: Therapeutic Navigation Between Scylla and Charybdis⁎⁎Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Authors: Franz H. Messerli, Delia Cotiga
Journal: Journal of the American College of Cardiology (2005)
COVID-19 hits viral hepatitis care for vulnerable populations
Authors: Udani Samarasekera
Journal: The Lancet. Gastroenterology & hepatology (2021)

On Jan 6, 2021, the UK Department of Health and Social Care in England (DHSC) and Public Health England (PHE) released updated guidance for commissioners and providers of services for people who use drugs or alcohol, calling for the reinstatement of testing and treatment for hepatitis C virus (HCV), which might have been curtailed by the COVID-19 pandemic.
H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model
Authors: Daniel Haag, Norman Mack, Patricia Benites Goncalves da Silva, Britta Statz, Jessica Clark, Koji Tanabe, Tanvi Sharma, Natalie Jäger, David T.W. Jones, Daisuke Kawauchi, Marius Wernig, Stefan M. Pfister
Journal: Cancer Cell (2021)
The Toxic Effects of an Incomplete Medication History
Authors: Mei-Ni Belzile, Kiran Battu, Peter E. Wu
Journal: JAMA Internal Medicine (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Supramolecular engineering of hydrogels for drug delivery
Authors: Stéphane Bernhard, Mark W. Tibbitt
Journal: Advanced Drug Delivery Reviews (2021)

Supramolecular binding motifs are increasingly employed in the design of biomaterials. The ability to rationally engineer specific yet reversible associations into polymer networks with supramolecular chemistry enables injectable or sprayable hydrogels that can be applied via minimally invasive administration. In this review, we highlight two main areas where supramolecular binding motifs are being used in the design of drug delivery systems: engineering network mechanics and tailoring drug–material affinity. Throughout, we highlight many of the established and emerging chemistries or binding motifs that are useful for the design of supramolecular hydrogels for drug delivery applications.
Adjuvant Therapy Approved for NSCLC
Authors: Rebecca Voelker
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment Outcomes and Clinical Characteristics of Patients with KRAS-G12C–Mutant Non–Small Cell Lung Cancer
Authors: Kathryn C. Arbour, Hira Rizvi, Andrew J. Plodkowski, Matthew D. Hellmann, Andrea Knezevic, Glenn Heller, Helena A. Yu, Marc Ladanyi, Mark G. Kris, Maria E. Arcila, Charles M. Rudin, Piro Lito, Gregory J. Riely
Journal: Clinical Cancer Research (2021)

Abstract Purpose: KRAS mutations are identified in approximately 30% of patients with non–small cell lung cancer (NSCLC). Novel direct inhibitors of KRAS G12C have shown activity in early-phase clinical trials. We hypothesized that patients with KRAS G12C mutations may have distinct clinical characteristics and responses to therapies. Experimental Design: Through routine next-generation sequencing, we identified patients with KRAS-mutant NSCLC treated at Memorial Sloan Kettering Cancer Center (New York, NY) from 2014 to 2018 and reviewed tumor characteristics, overall survival, and treatment outcomes. Results: We identified 1,194 patients with KRAS-mutant NSCLC, including 770 with recurrent or metastatic disease. KRAS G12C mutations were present in 46% and KRAS non-G12C mutations in 54%. Patients with KRAS G12C had a higher tumor mutation burden (median, 8.8 vs. 7 mut/Mb; P = 0.006) and higher median PD-L1 expression (5% vs. 1%). The comutation patterns of STK11 (28% vs. 29%) and KEAP1 (23% vs. 24%) were similar. The median overall survivals from diagnosis were similar for KRAS G12C (13.4 months) and KRAS non-G12C mutations (13.1 months; P = 0.96). In patients with PD-L1 ≥50%, there was not a significant difference in response rate with single-agent immune checkpoint inhibitor for patients with KRAS G12C mutations (40% vs. 58%; P = 0.07). Conclusions: We provide outcome data for a large series of patients with KRAS G12C–mutant NSCLC with available therapies, demonstrating that responses and duration of benefit with available therapies are similar to those seen in patients with KRAS non-G12C mutations. Strategies to incorporate new targeted therapies into the current treatment paradigm will need to consider outcomes specific to patients harboring KRAS G12C mutations.
COVID-19 and endoscopic services: the impact of delays in therapeutic colonoscopies on patients
Authors: Syazeddy Samani, Nasir Mir, David N Naumann, Michael Ding, Sharad Karandikar, Jason Goh, Marietta Iacucci, Marcus Mottershead, Vanja Giljaca
Journal: Gut (2021)

We are writing in relation to the study by Rutter et al with interest.1 The COVID-19 pandemic has resulted in major changes to healthcare delivery in many clinical areas including endoscopic services.1–3 The British Society of Gastroenterology (BSG) and Joint Advisory Group for Gastrointestinal Endoscopy (JAG) issued guidance for endoscopic services on 23 March 2020 recommending activities prioritising emergencies or essential procedures and postponement of non-emergency cases, bowel cancer screening and surveillance.4

The study by Rutter et al reported a substantial reduction to as low as 5% of normal endoscopic activity in the UK earlier on in the pandemic with only a 20% increase of pre-COVID-19 levels 10 weeks later. Endoscopic cancer detection rate reduced by 58% overall, with a worrying 72% reduction for colorectal cancer during the study period.1 A national survey of UK endoscopy leads in May 2020 showed a substantial number of endoscopy services stopped performing endoscopy with an anticipated slow recovery and trebling …
An International, Retrospective Study of Off-Label Biologic Use in the Treatment of Hypereosinophilic Syndromes (HES)
Authors: Michael Chen, Praveen Akuthota, Timothy Lax, Sameer Mathur, Princess Ogbogu, Thanai Pongdee, Marc Rothenberg, Florence Roufosse, Dagmar Simon, Miguel Stein, Sa Wang, Michael Wechsler, Amy Klion, Bruce Bochner
Journal: Journal of Allergy and Clinical Immunology (2021)
The impact of socioeconomic status (SES) on cognitive outcomes following radiotherapy for pediatric brain tumors: a prospective, longitudinal trial
Authors: Victoria A Torres, Jason M Ashford, Evelyn Wright, Jiahui Xu, Hui Zhang, Thomas E Merchant, Heather M Conklin
Journal: Neuro-Oncology (2021)

Socioeconomic status (SES) is a determinant of cognitive and academic functioning among healthy and ill children; however, few pediatric oncology studies examine SES and long-term cognitive functioning. The current study systematically investigated SES as a predictor of cognitive outcomes among children treated for localized brain tumors (BT) with photon radiation therapy (RT).248 children treated on a prospective, longitudinal, phase II trial of conformal RT (54-59.4 Gy) for ependymoma, low-grade glioma, or craniopharyngioma were monitored serially with cognitive assessments (intelligence quotient [IQ], reading, math, attention, adaptive function) for 10 years (2209 observations, median age at RT = 6.6 years, 48% male, 80% Caucasian). SES was derived from the Barratt Simplified Measure of Social Status, which incorporates parental occupation, education, and marital status.Overall, SES scores fell in the low range (Barratt median = 37). At pre-RT baseline, linear mixed models revealed significant associations between SES and IQ, reading, math, attention, and adaptive function, with higher SES associated with better performance (P < .005). SES predicted change over time in IQ, reading, and math; higher SES was associated with less decline (P < .001). Accounting for sex and age at RT, SES remained predictive of IQ, reading, and math. Analysis of variance revealed a greater relative contribution of SES than sex or age at RT to reading and math.SES represents a novel predictor of cognitive performance before and after RT for pediatric BT. These findings have broad implications as high SES represents a protective factor. Developing interventions to mitigate the effects of low SES is warranted.
Reconstruction of Microbial Haplotypes by Integration of Statistical and Physical Linkage in Scaffolding
Authors: Chen Cao, Jingni He, Lauren Mak, Deshan Perera, Devin Kwok, Jia Wang, Minghao Li, Tobias Mourier, Stefan Gavriliuc, Matthew Greenberg, A Sorana Morrissy, Laura K Sycuro, Guang Yang, Daniel C Jeffares, Quan Long
Journal: Molecular Biology and Evolution (2021)

DNA sequencing technologies provide unprecedented opportunities to analyze within-host evolution of microorganism populations. Often, within-host populations are analyzed via pooled sequencing of the population, which contains multiple individuals or "haplotypes." However, current next-generation sequencing instruments, in conjunction with single-molecule barcoded linked-reads, cannot distinguish long haplotypes directly. Computational reconstruction of haplotypes from pooled sequencing has been attempted in virology, bacterial genomics, metagenomics, and human genetics, using algorithms based on either cross-host genetic sharing or within-host genomic reads. Here, we describe PoolHapX, a flexible computational approach that integrates information from both genetic sharing and genomic sequencing. We demonstrated that PoolHapX outperforms state-of-the-art tools tailored to specific organismal systems, and is robust to within-host evolution. Importantly, together with barcoded linked-reads, PoolHapX can infer whole-chromosome-scale haplotypes from 50 pools each containing 12 different haplotypes. By analyzing real data, we uncovered dynamic variations in the evolutionary processes of within-patient HIV populations previously unobserved in single position-based analysis.
Diffusion Capacity Abnormalities for Carbon Monoxide in Patients with COVID-19 At Three-Month Follow-up
Authors: Wei Qin, Shi Chen, Yunxia Zhang, Fen Dong, Zhu Zhang, Bingzhu Hu, Ziyang Zhu, Fajiu Li, Xiaojiang Wang, Yimin Wang, Kaiyuan Zhen, Jing Wang, YuLei Wan, Hongbo Li, Ismaïl Elalamy, Chenghong Li, Zhenguo Zhai, Chen Wang
Journal: European Respiratory Journal (2021)

Objective To evaluate pulmonary function and clinical symptoms in coronavirus disease 2019 (COVID-19) survivors within 3 months after hospital discharge, and to identify risk factors associated with impaired lung function. Methods and material COVID-19 patients were prospectively followed-up with pulmonary function tests and clinical characteristics for 3 months following discharge from a hospital in Wuhan, China between January and February 2020. Results 647 patients were included. 87 (13%) patients presented with weakness, 63 (10%) with palpitations and 56 (9%) with dyspnoea. The prevalence of each of the three symptoms were markedly higher in severe patients than nonsevere patients (19% versus 10% for weakness, p=0.003; 14% versus 7% for palpitations, p=0.007; 12% versus 7% for dyspnoea, p=0.014). Results of multivariable regression showed increased odds of ongoing symptoms among severe patients (OR 1.7, 95% CI 1.1–2.6; p=0.026) or patients with longer hospital stays (OR 1.03, 95% CI 1.00–1.05; p=0.041). Pulmonary function test results were available for 81 patients, including 41 nonsevere and 40 severe patients. In this subgroup, 44 (54%) patients manifested abnormal diffusing capacity of the lung for carbon monoxide ( D LCO ) (68% severe versus 42% nonsevere patients, p=0.019). Chest computed tomography (CT) total severity score &gt;10.5 (OR 10.4, 95% CI 2.5–44.1; p=0.001) on admission and acute respiratory distress syndrome (ARDS) (OR 4.6, 95% CI 1.4–15.5; p=0.014) were significantly associated with impaired D LCO . Pulmonary interstitial damage may be associated with abnormal D LCO . Conclusion Pulmonary function, particularly D LCO , declined in COVID-19 survivors. This decrease was associated with total severity score of chest CT &gt;10.5 and ARDS occurrence. Pulmonary interstitial damage might contribute to the imparied D LCO .
RETRACTED ARTICLE: KDM4 orchestrates epigenomic remodeling of senescent cells and potentiates the senescence-associated secretory phenotype
Authors: Boyi Zhang, Qilai Long, Shanshan Wu, Qixia Xu, Shuling Song, Liu Han, Min Qian, Xiaohui Ren, Hanxin Liu, Jing Jiang, Jianming Guo, Xiaoling Zhang, Xing Chang, Qiang Fu, Eric W-F Lam, Judith Campisi, James L. Kirkland, Yu Sun
Journal: Nature Aging (2021)
Author Correction: The softness of tumour-cell-derived microparticles regulates their drug-delivery efficiency
Authors: Qingle Liang, Nana Bie, Tuying Yong, Ke Tang, Xiaolong Shi, Zhaohan Wei, Haibo Jia, Xiaoqiong Zhang, Haiyan Zhao, Wei Huang, Lu Gan, Bo Huang, Xiangliang Yang
Journal: Nature Biomedical Engineering (2021)
Abstract PO007: Evaluation of crosstalk between estrogen and Wnt signaling in endometrial cancer
Authors: Krystle Osby, Adriana C. Rodriguez, Jay Gertz
Journal: Clinical Cancer Research (2021)

Abstract Estrogen signaling through estrogen receptor alpha (ER) is considered to be a driving oncogenic signal in type 1 endometrial cancer. However, excess estrogen exposure isn’t sufficient to initiate tumorigenesis in mouse models, suggesting additional genomic or epigenomic changes are required for tumor formation. Activating mutations in beta-catenin, a downstream regulator of Wnt signaling, are prevalent in type I endometrial tumors, with almost 40% of cases harboring these mutations. The combination of excess estrogen and Wnt signals appears to drive endometrial cancer formation and growth, but the mechanisms underlying interplay between these pathways is not well understood. Based on previous studies and our preliminary data, we are currently exploring the hypothesis that beta-catenin acts as a cofactor for ER, representing a convergence of these two oncogenic pathways. Using Ishikawa cells, a type 1 endometrial cancer cell line expressing wildtype beta-catenin, we are measuring differences in gene expression and chromatin between cells that have been induced with 17-beta-estradiol (E2), Wnt3a, or the combination. Our findings suggest that a combination induction affects where ER and beta-catenin bind the genome. In the presence of E2 and Wnt3a, ER’s genomic occupancy expanded and revealed Wnt dependent ER sites separate from canonical ER and Wnt binding sites. Analysis of acetylation of lysine 27 on histone H3 (H3K27ac) using ChIP-seq support this pattern, where acetylation is enriched in the combination treatment over an E2 or Wnt3a induction alone. Additionally, we observed unique gene expression patterns with a simultaneous E2 and Wnt3a induction. We are in the process of creating an isogenic Ishikawa cell line that harbors an activating beta-catenin mutation to determine molecular differences between Wnt ligand activation and constitutively active beta-catenin and discover how these forms of Wnt activation relate to estrogen signaling. Overall, we hope our studies deepen our understanding of estrogen driven transcriptional regulation and shed light on the functional consequences of beta-catenin activating mutations in endometrial cancer. Citation Format: Krystle Osby, Adriana C. Rodriguez, Jay Gertz. Evaluation of crosstalk between estrogen and Wnt signaling in endometrial cancer [abstract]. In: Proceedings of the AACR Virtual Special Conference: Endometrial Cancer: New Biology Driving Research and Treatment; 2020 Nov 9-10. Philadelphia (PA): AACR; Clin Cancer Res 2021;27(3_Suppl):Abstract nr PO007.
Hydroyxurea improves cerebral oxygen saturation in children with sickle cell anemia
Authors: Kristine Karkoska, Charles T. Quinn, Omar Niss, Amanda Pfeiffer, Min Dong, Alexander A. Vinks, Patrick T. McGann
Journal: American Journal of Hematology (2021)

Neurologic complications are common in patients with sickle cell anemia (SCA), but conventional tools such as MRI and transcranial Doppler ultrasonography (TCD) do not fully assess cerebrovascular pathology. Cerebral tissue oximetry measures mixed oxygen saturation in the frontal lobes (SCT O2 ) and provides early prognostic information about tissue at risk of ischemic injury. Untreated patients with SCA have significantly lower SCT O2 than healthy controls that declines with age. Hydroxyurea is effective in preventing many SCA-related complications, but the degree to which it preserves normal neurophysiology is unclear. We analyzed participants enrolled in the Therapeutic Response Evaluation and Adherence Trial (TREAT, NCT02286154), which enrolled participants initiating hydroxyurea using individualized dosing (new cohort) and those previously taking hydroxyurea (old cohort) and was designed to monitor the long-term benefits of hydroxyurea. Cerebral oximetry was performed at baseline and annually. For the new cohort (median starting age = 12 months, n = 55), mean baseline SCT O2 was normal before starting hydroxyurea (mean 65%, 95% CI 58-72%) and significantly increased after 2 years (mean 72%, 95% CI 65-79%, p < .001). The SCT O2 for patients receiving long-term hydroxyurea (median age = 9.6 years) was normal at study entry (mean 66%, 95% CI 58-74%) and remained stable across 2 years. Both cohorts had significantly higher SCT O2 than published data from predominantly untreated SCA patients. Cerebral oximetry is a non-invasive method to assess cerebrovascular pathology that complements conventional imaging. Our results indicate that hydroxyurea suggests protection against neurophysiologic changes seen in untreated SCA.
Loss of sense of smells associated with sour taste is a possible diagnostic marker for COVID-19
Authors: Mohammad Asad, Esha Sehanobish, Valerie Fong, Meaghan O'Neill, Viraj Patel, Danielle Bottalico, Merhunisa Karagic, Denisa Ferastraoaru, Inessa Gendlina, Mali Barbi, Meryl Kravitz, Cynthia Matsumura, Denise Tejera, Golda Hudes, Nadeem Akbar, Avindra Nath, Bryan Smith, Thomas Ow, Elina Jerschow
Journal: Journal of Allergy and Clinical Immunology (2021)
Adherent-invasive E. coli metabolism of propanediol in Crohn’s disease regulates phagocytes to drive intestinal inflammation
Authors: Monica Viladomiu, Maeva L. Metz, Svetlana F. Lima, Wen-Bing Jin, Lance Chou, Chun-Jun Guo, Gretchen E. Diehl, Kenneth W. Simpson, Ellen J. Scherl, Randy S. Longman
Journal: Cell Host & Microbe (2021)