tbuckley/cabot-search huggingface dataset:
Abstract 12934: Valve, Ventricle, Vessel or Virus: Who is the Shocking Culprit?
Authors: Sudhi Tyagi, Harshal Patil, Robert Miles, Elizabeth Siegel, Salman Allana, Michael Salinger, Peter Mason, Andrew Rosenblum
Journal: Circulation (2020)

Introduction: Determining the etiology of dyspnea in patients with structural heart disease can be challenging, especially in the current era with high prevalence of COVID-19. Our case highlights the importance of evaluating bioprosthetic valve function in the setting of a change in clinical status. Case: An 82 year old female with surgical coronary revascularization and bioprosthetic aortic valve replacement in 2003 presented with dyspnea. Her evaluation revealed hypoxemia, leukocytosis and a chest x-ray supportive of viral infection when the local prevalence of both COVID-19 and influenza were at their peak. She was admitted to the intensive care unit with impending respiratory failure most likely from an infectious etiology. Echocardiogram revealed an ejection fraction (EF) of 25% and severe prosthetic aortic regurgitation with a pressure half time of 117ms ( Figure ). Six months prior, she had normal EF and normal prosthetic valve function. Interestingly, she lacked a wide pulse pressure, murmur of aortic insufficiency, and other characteristic exam findings of valvular dysfunction. The patient rapidly deteriorated into cardiogenic shock. Following urgent evaluation for transcatheter aortic valve replacement, she had successful valve-in-valve deployment of a 23mm Edwards S3 Ultra valve. Her hemodynamic parameters improved immediately and she was weaned from inotropic support 1 day following valve replacement. Conclusions: Evaluation of prosthetic valve function is integral when a patient’s clinical condition changes. In our patient, depressed EF resulting in an elevated left ventricular end-diastolic pressure likely diminished the regurgitant fraction and the expected aortic insufficiency murmur. Periodic evaluation of prosthetic heart valve function is necessary, particularly when the patient’s clinical condition changes. Acute severe aortic regurgitation with cardiogenic shock is fatal without rapid evaluation and valve replacement.
Long-Term Follow up of 90y-Ibritumomab Tiuxetan, Fluadarabine and TBI Based Non-Myeloablative Allogeneic Transplant Conditioning for Persistent High-Risk B-Cell Lymphoma
Authors: Camille E. Puronen, Ryan D. Cassaday, Philip A. Stevenson, Brenda M. Sandmaier, Mary E. Flowers, Damian J. Green, David G. Maloney, Rainer F. Storb, Oliver W. Press, Ajay K. Gopal
Journal: Blood (2017)
Abstract 239: Frequency of Advanced Cardiac Life Support Medication Use and Association With Survival During In-Hospital Cardiac Arrest
Authors: Paul Benz, Nicole Brenner, Stephanie Woo, Stephen Chong, Matthew Wilson, Dorothy Heinrichs, Jeffrey Dubin, Munish Goyal
Journal: Circulation (2018)

Introduction: Resuscitation medication shortages are widespread across the US. We sought to determine the frequency and quantity of meds used during IHCA. Methods: Retrospective, single center, chart review at a large, urban teaching hospital. Adults over 18 who suffered IHCA between Jan 2017 and Mar 2018 were identified. Trained and supervised research assistants used a standardized data tool to extract data from the EMR. Primary outcome was the frequency and quantity of ACLS meds used during IHCA. Secondary outcomes included evaluating the association of med administration with ROSC and survival as well as the use of sodium bicarb with survival in patients with pre-existing end stage renal disease. Results: Criteria were met for 181 IHCA events. Demographics: 71% (128 of 181) black; mean age 65; and 46% (83 of 181) women. Epi was given in 86.7% (157 of 181) cases, with average cumulative dose of 4.2 mg, sodium bicarb given in 63.5% (115 of 181), average dose of 1.9 amps, calcium chloride given in 39.2% (71 of 181), average dose of 1.9 amps, amiodarone was given in 30.9% (56 of 181), average dose of 311.8 mg, and atropine was given in 13.8% (25 of 181), average dose of 1.3 amps. Administration of sodium bicarb was associated with lower rates of ROSC (OR 0.31, 95% CI 0.18 to 0.83) and lower survival (OR 0.31, 95% CI 0.13 to 0.73). Administration of mag sulfate was associated with lower rates of ROSC (OR 0.33, 95% CI 0.13 to 0.83), but no difference in survival (OR 0.34, 95% CI 0.10 to 1.14). Administration of epi, amiodarone, calcium, dextrose, or atropine was not associated with a change in rates of ROSC or survival. In patients with pre-existing ESRD (45 of 181), 73.3% (33 of 45) received sodium bicarb, with 51.5% (17 of 33) achieving ROSC, and 12.1% (4 of 33) surviving to discharge. In patients without ESRD (136 of 181), 60.3% (82 of 136) received sodium bicarb, with 65.9% (54/82) achieving ROSC, and 22.0% (18 of 82) surviving to discharge. (12.1% vs 22.0% p = 0.224). Conclusions: Substantial amounts of drugs with known recent shortage are used in IHCA with no significant increase in ROSC or survival to discharge. Administration of sodium bicarb during IHCA is associated with lower rates of ROSC and survival. These results may be due to confounders such as code duration.
Safety of Breast-Conserving Surgery in Breast Cancer and Risk of Overtreatment vs Undertreatment
Authors: Lisa A. Newman
Journal: JAMA Surgery (2021)

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IMPACT OF SAPIEN 3 TRANSCATHETER AORTIC VALVE REPLACEMENT ON LEFT VENTRICULAR OUTFLOW TRACT AND MITRAL ANNULAR GEOMETRY - IMPLICATIONS ON TRANSCATHETER MITRAL VALVE REPLACEMENT
Authors: Syed Zaid, Akiva Rosenzveig, Joshua Hsu, Medha Biswas, Aaqib Malik, Cenap Undemir, Joshua Goldberg, Steven Lansman, Gilbert Tang, Hasan Ahmad
Journal: Journal of the American College of Cardiology (2021)
CARDIAC MUSCLE INJURY AND RIGHT VENTRICULAR ECHOCARDIOGRAPHIC CORRELATIONS IN PATIENTS WITH COVID-19
Authors: Mostafa Abohelwa, Mohamed Elmassry, Ahmed M. Mohamed, Gaspar Del Rio-Pertuz, Kanak Parmar, Kiran Ali, Sanjana Rao, Bianca Patel, John Abdelmalek, Konner Hamous, Emad Elgwairi, Sofia Prieto, Kenneth Nugent, Pooja Sethi
Journal: Journal of the American College of Cardiology (2021)
TEMPORAL TRENDS IN DIAGNOSTIC TESTING PATTERNS FOR WILD-TYPE TRANSTHYRETIN AMYLOID CARDIOMYOPATHY IN THE MEDICARE FEE-FOR-SERVICE POPULATION
Authors: Jamieson M Bourque, Alexander Schepart, Rahul Bhambri, Adam Castaño, Alex O’Brien, Yong Chen, Sapna Prasad, Anuja Roy, Justin Grodin
Journal: Journal of the American College of Cardiology (2021)
International consensus to standardise histopathological scoring for small bowel strictures in Crohn’s disease
Authors: Ilyssa O Gordon, Dominik Bettenworth, Arne Bokemeyer, Amitabh Srivastava, Christophe Rosty, Gert de Hertogh, Marie E Robert, Mark A Valasek, Ren Mao, Jiannan Li, Noam Harpaz, Paula Borralho, Reetesh K Pai, Robert Odze, Roger Feakins, Claire E Parker, Leonardo Guizzetti, Tran Nguyen, Lisa M Shackelton, William J Sandborn, Vipul Jairath, Mark Baker, David Bruining, Joel G Fletcher, Brian G Feagan, Rish K Pai, Florian Rieder
Journal: Gut (2021)

Objective Effective medical therapy and validated trial outcomes are lacking for small bowel Crohn’s disease (CD) strictures. Histopathology of surgically resected specimens is the gold standard for correlation with imaging techniques. However, no validated histopathological scoring systems are currently available for small bowel stricturing disease. We convened an expert panel to evaluate the appropriateness of histopathology scoring systems and items generated based on panel opinion. Design Modified RAND/University of California Los Angeles methodology was used to determine the appropriateness of 313 candidate items related to assessment of CD small bowel strictures. Results In this exercise, diagnosis of naïve and anastomotic strictures required increased bowel wall thickness, decreased luminal diameter or internal circumference, and fibrosis of the submucosa. Specific definitions for stricture features and technical sampling parameters were also identified. Histopathologically, a stricture was defined as increased thickness of all layers of the bowel wall, fibrosis of the submucosa and bowel wall, and muscularisation of the submucosa. Active mucosal inflammatory disease was defined as neutrophilic inflammation in the lamina propria and any crypt or intact surface epithelium, erosion, ulcer and fistula. Chronic mucosal inflammatory disease was defined as crypt architectural distortion and loss, pyloric gland metaplasia, Paneth cell hyperplasia, basal lymphoplasmacytosis, plasmacytosis and fibrosis, or prominent lymphoid aggregates at the mucosa/submucosa interface. None of the scoring systems used to assess CD strictures were considered appropriate for clinical trials. Conclusion Standardised assessment of gross pathology and histopathology of CD small bowel strictures will improve clinical trial efficiency and aid drug development.
Aspiration fuels willpower: Evidence from the addiction literature
Authors: Gene M. Heyman
Journal: Behavioral and Brain Sciences (2021)

Ainslie identifies two possible motivational sources for resolve: "thinking categorically" and "intertemporal bargaining." Ainslie opts for intertemporal bargaining, adding that thinking categorically has no motivational power. The most researched instance of willpower is remission from addiction. This literature shows that aspirations for a more desirable identity and comfortable lifestyle motivate remission. In other words, "thinking categorically" drives willpower.
BFAR coordinates TGFβ signaling to modulate Th9-mediated cancer immunotherapy
Authors: Siyu Pei, Mingzhu Huang, Jia Huang, Xiaodong Zhu, Hui Wang, Simona Romano, Xiuyu Deng, Yan Wang, Yixiao Luo, Shumeng Hao, Jing Xu, Tao Yu, Qingchen Zhu, Jia Yuan, Kunwei Shen, Zhiqiang Liu, Guohong Hu, Chao Peng, Qingquan Luo, Zhenzhen Wen, Dongfang Dai, Yichuan Xiao
Journal: The Journal of Experimental Medicine (2021)

TGFβ is essential for the generation of anti-tumor Th9 cells; on the other hand, it causes resistance against anti-tumor immunity. Despite recent progress, the underlying mechanism reconciling the double-edged effect of TGFβ signaling in Th9-mediated cancer immunotherapy remains elusive. Here, we find that TGFβ-induced down-regulation of bifunctional apoptosis regulator (BFAR) represents the key mechanism preventing the sustained activation of TGFβ signaling and thus impairing Th9 inducibility. Mechanistically, BFAR mediates K63-linked ubiquitination of TGFβR1 at K268, which is critical to activate TGFβ signaling. Thus, BFAR deficiency or K268R knock-in mutation suppresses TGFβR1 ubiquitination and Th9 differentiation, thereby inhibiting Th9-mediated cancer immunotherapy. More interestingly, BFAR-overexpressed Th9 cells exhibit promising therapeutic efficacy to curtail tumor growth and metastasis and promote the sensitivity of anti–PD-1–mediated checkpoint immunotherapy. Thus, our findings establish BFAR as a key TGFβ-regulated gene to fine-tune TGFβ signaling that causes Th9 induction insensitivity, and they highlight the translational potential of BFAR in promoting Th9-mediated cancer immunotherapy.
CORRELATION BETWEEN WORLD HEALTH ORGANIZATION FUNCTIONAL CLASS ASSESSMENT AND THE DISTANCE WALKED DURING THE 6-MINUTE WALK TEST
Authors: Radha S. Gopalan, Ewelina Wojtaszek, Hayley Mitchel, Byomesh Tripathi, Anantharam Kalya, Srikanth Seethala, Francisco Arabia
Journal: Journal of the American College of Cardiology (2021)
EFFECT OF NEO-CHORD ANGULATION ON CHORDAL FORCE DURING MITRAL VALVE PROLAPSE REPAIR: AN IN VITRO STUDY
Authors: Vahid Sadri, Keshav Kohli, Jorge Jimenez, William Cranford, Abigail R Berry, Daniel Grinberg, W. Randolph Chitwood, Ajit Yoganathan
Journal: Journal of the American College of Cardiology (2021)
The inflammatory profile of exacerbations in patients with severe refractory eosinophilic asthma receiving mepolizumab (the MEX study): a prospective observational study
Authors: P Jane McDowell, Sarah Diver, Freda Yang, Catherine Borg, John Busby, Vanessa Brown, Rahul Shrimanker, Ciara Cox, Christopher E Brightling, Rekha Chaudhuri, Ian D Pavord, Liam G Heaney, P Jane McDowell, Sarah Diver, Freda Yang, Catherine Borg, John Busby, Vanessa Brown, Rahul Shrimanker, Ciara Cox, Christopher E Brightling, Rekha Chaudhuri, Ian D Pavord, Liam G Heaney, Christopher Wise, Christine McAnally, Stephen Drain, Vijay Mistry, Hannah Arnold, Claudia Micieli, William Monterio,, Marc Jones, Hattie Ellis, Samantha Thulborn, Linda Cheyne, Esther Ramsey, Sarah Howes, Michelle Bourne, Tracy Thorton, Sarah Edwards, Helen Evans, Steven Smith, Tracyanne Grandison
Journal: The Lancet Respiratory Medicine (2021)
CLINICAL IMPACT OF HIGH-SENSITIVITY CARDIAC TROPONIN T IMPLEMENTATION IN A UNITED STATES REGIONAL HEALTHCARE SYSTEM
Authors: Olatunde Ola, Ashok Akula, Laura De Michieli, Marshall Dworak, Erika Crockford, Nicholas Rastas, Ronstan Lobo, Swetha Karturi, Ramila A. Mehta, David O. Hodge, Eric D. Grube, Scott Wohlrab, Tahir Tak, Charles Cagin, Allan Jaffe, Yader Sandoval
Journal: Journal of the American College of Cardiology (2021)
Three-dimensional-printed individualized porous implants: A new “implant-bone” interface fusion concept for large bone defect treatment
Authors: Teng Zhang, Qingguang Wei, Hua Zhou, Zehao Jing, Xiaoguang Liu, Yufeng Zheng, Hong Cai, Feng Wei, Liang Jiang, Miao Yu, Yan Cheng, Daoyang Fan, Wenhao Zhou, Xinhong Lin, Huijie Leng, Jian Li, Xinyu Li, Caimei Wang, Yun Tian, Zhongjun Liu
Journal: Bioactive Materials (2021)

Bone defect repairs are based on bone graft fusion or replacement. Current large bone defect treatments are inadequate and lack of reliable technology. Therefore, we aimed to investigate a simple technique using three-dimensional (3D)-printed individualized porous implants without any bone grafts, osteoinductive agents, or surface biofunctionalization to treat large bone defects, and systematically study its long-term therapeutic effects and osseointegration characteristics. Twenty-six patients with large bone defects caused by tumor, infection, or trauma received treatment with individualized porous implants; among them, three typical cases underwent a detailed study. Additionally, a large segmental femur defect sheep model was used to study the osseointegration characteristics. Immediate and long-term biomechanical stability was achieved, and the animal study revealed that the bone grew into the pores with gradual remodeling, resulting in a long-term mechanically stable implant-bone complex. Advantages of 3D-printed microporous implants for the repair of bone defects included 1) that the stabilization devices were immediately designed and constructed to achieve early postoperative mobility, and 2) that osseointegration between the host bone and implants was achieved without bone grafting. Our osseointegration method, in which the "implant-bone" interface fusion concept was used instead of "bone-bone" fusion, subverts the traditional idea of osseointegration.
SOCIOECONOMIC STATUS AND TRENDS IN ALL-CAUSE IN-HOSPITAL MORTALITY AMONGST PATIENTS ADMITTED WITH ATRIAL FIBRILLATION IN THE UNITED STATES
Authors: Chaitanya Rojulpote, Shivaraj Patil, Karthik Gonuguntla, Manish Kumar, Srinivas Nadadur, Abhishek Achunair, Paco Bravo, Tapan Buch, Purveshkumar Patel, Kashyap Kela, Vijay Pratap Singh, Samir Pancholy
Journal: Journal of the American College of Cardiology (2021)
Case series of four re-infections with a SARS-CoV-2 B.1.351 variant, Luxembourg, February 2021
Authors: Thérèse Staub, Vic Arendt, Esther Calvo Lasso de la Vega, Pierre Braquet, Christian Michaux, Michel Kohnen, Chantal Tsobo, Tamir Abdelrahman, Anke Wienecke-Baldacchino, Jean-Hugues Francois
Journal: Eurosurveillance (2021)

We describe four SARS-CoV-2 re-infections with a B.1.351 variant in 2021, in healthcare workers (HCWs) previously infected in 2020, before detection of this variant in Europe. Cases live in France, near the border with Luxembourg, where variants B.1.351 and B.1.1.7 circulated. All work in the same hospital unit where a cluster of COVID 19 with B1.351 variant occurred, affecting patients and HCWs. Before the cluster onset, HCWs used surgical masks, as per recommendations. After cluster onset, HCWs used FFP2 masks.
Intracerebral Hemorrhage and Exposure to Antithrombotic Drugs
Authors: Peter Brønnum Nielsen, Truman J. Milling, Gregory Y. H. Lip
Journal: JAMA Network Open (2021)

Stine Munk Hald, MD; Sören Möller, PhD; Luis Alberto García Rodríguez, MD; Rustam Al-Shahi Salman, PhD; Mike Sharma, MSc; Hanne Christensen, DMSc; Maja Hellfritzsch, MD, PhD; Anton Pottegård, DMSc; Jesper Hallas, DMSc; David Gaist, MD, PhD
CBD Use in Children—Miracle, Myth, or Mystery?
Authors: Ruchita Kachru, Casey Perry-Lunardo, Lindsay A. Thompson
Journal: JAMA Pediatrics (2021)

CBD Use in Children-Miracle, Myth, or Mystery?Cannabis plants have 2 varieties: marijuana and hemp.Both contain tetrahydrocannabinol (THC) and cannabidiol (CBD).The levels of THC in marijuana are significant, while hemp contains mostly CBD.THC is the ingredient that can cause a "high" and can lead to addiction and psychosis.Since hemp was legalized in 2018, CBD products have flourished.They claim to cure problems such as acne, cancer, and mental health issues.Many celebrate cases like Charlotte, the little girl whose seizures responded well to a specifically formulated concentrate of CBD known as Charlotte's Web.However, there is limited scientific evidence to back these claims, and CBD may carry risks too.Cannabis in general has a lot of health effects, regulating blood pressure, sugar, mood, pain, hunger, and stress responses.These effects have not been well studied in children.Adolescents are using CBD/THC products frequently as they see these products trending on social media or advertised on storefronts.Teens are even trying new kinds of products like Delta-8, thinking that they are safe.Adults use CBD to treat chronic pain, nausea, vomiting, mood disorders, and opiate addiction.In children, the only US Food and Drug Administration-approved CBD product is Epidiolex (Greenwich Biosciences).It can be used only in clinical trials for 2 rare forms of childhood seizure disorders that do not respond to medications.Also, new studies in children with autism spectrum disorder show promising improvement in hyperactivity, anxiety, sleep problems, and self-injurious behaviors.CBD is also being studied for depression and spasticity.However, CBD has important adverse effects.CBD is known to cause sleepiness, fatigue,
Relationship of SARS-CoV-2–specific CD4 response to COVID-19 severity and impact of HIV-1 and tuberculosis coinfection
Authors: Catherine Riou, Elsa du Bruyn, Cari Stek, Remy Daroowala, Rene T. Goliath, Fatima Abrahams, Qonita Said-Hartley, Brian W. Allwood, Nei-Yuan Hsiao, Katalin A. Wilkinson, Cecilia S. Lindestam Arlehamn, Alessandro Sette, Sean Wasserman, Robert J. Wilkinson
Journal: Journal of Clinical Investigation (2021)

T cells are involved in control of coronavirus disease 2019 (COVID-19), but limited knowledge is available on the relationship between antigen-specific T cell response and disease severity. Here, we used flow cytometry to assess the magnitude, function, and phenotype of SARS coronavirus 2–specific (SARS-CoV-2–specific) CD4+ T cells in 95 hospitalized COVID-19 patients, 38 of them being HIV-1 and/or tuberculosis (TB) coinfected, and 38 non–COVID-19 patients. We showed that SARS-CoV-2–specific CD4+ T cell attributes, rather than magnitude, were associated with disease severity, with severe disease being characterized by poor polyfunctional potential, reduced proliferation capacity, and enhanced HLA-DR expression. Moreover, HIV-1 and TB coinfection skewed the SARS-CoV-2 T cell response. HIV-1–mediated CD4+ T cell depletion associated with suboptimal T cell and humoral immune responses to SARS-CoV-2, and a decrease in the polyfunctional capacity of SARS-CoV-2–specific CD4+ T cells was observed in COVID-19 patients with active TB. Our results also revealed that COVID-19 patients displayed reduced frequency of Mycobacterium tuberculosis–specific CD4+ T cells, with possible implications for TB disease progression. These results corroborate the important role of SARS-CoV-2–specific T cells in COVID-19 pathogenesis and support the concept of altered T cell functions in patients with severe disease.
CARDIAC INVOLVEMENT IN COVID-19 RELATED MULTISYSTEM INFLAMMATORY SYNDROME IN CHILDREN (MIS-C) : A CASE SERIES FROM A TERTIARY CARE PEDIATRIC HOSPITAL
Authors: Diana Bernal, Mohammad Hasan, Yahia Hejazi, Sharon Bout-Tabaku, Patrick Tang, Mohammed Janahi, Karim Diab
Journal: Journal of the American College of Cardiology (2021)
A SYSTEMATIC REVIEW AND METAANALYSIS OF LUNG ULTRASOUND GUIDED THERAPY OF AMBULATORY PATIENTS WITH CHRONIC HEART FAILURE
Authors: Mohammed Mhanna, Azizullah Beran, Salik Nazir, Omar Sajdeya, Omar Srour, Hazem Ayesh, Ahmed Elzanaty, Ehab Eltahawy
Journal: Journal of the American College of Cardiology (2021)
IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease
Authors: Andrea S. Henden, Motoko Koyama, Renee J. Robb, Adriana Forero, Rachel D. Kuns, Karshing Chang, Kathleen S. Ensbey, Antiopi Varelias, Stephen H. Kazakoff, Nicole Waddell, Andrew D. Clouston, Rabina Giri, Jakob Begun, Bruce R. Blazar, Mariapia A. Degli-Esposti, Sergei V. Kotenko, Steven W. Lane, Kate L. Bowerman, Ram Savan, Philip Hugenholtz, Kate H. Gartlan, Geoffrey R. Hill
Journal: Blood (2021)
A PNPLA3 Polymorphism Confers Lower Susceptibility to Incident Diabetes Mellitus in Subjects With Nonalcoholic Fatty Liver Disease
Authors: Seoil Moon, Goh Eun Chung, Sae Kyung Joo, Jeong Hwan Park, Mee Soo Chang, Ji Won Yoon, Bo Kyung Koo, Won Kim
Journal: Clinical Gastroenterology and Hepatology (2021)
WATCH FOR THE WATCHMAN’S COMPLICATION: ATRIAL SEPTAL HEMATOMA MIMICKING AS LEFT ATRIAL THROMBUS
Authors: Niravkumar Patel, Azad Patel, Sonia Dogra, Jaimin Kapadia, Viraj Brahmbhatt, Vipul Brahmbhatt, Camelia Chirculescu
Journal: Journal of the American College of Cardiology (2021)