tbuckley/cabot-search huggingface dataset:
Internalizing psychopathology and all‐cause mortality: a comparison of transdiagnostic vs. diagnosis‐based risk prediction
Authors: Hyunsik Kim, Nicholas A. Turiano, Miriam K. Forbes, Roman Kotov, Robert F. Krueger, Nicholas R. Eaton
Journal: World Psychiatry (2021)

Previous studies have documented the utility of a transdiagnostic internalizing factor in predicting important future outcomes (e.g., subsequent mental disorder diagnoses). To date, however, no study has investigated whether an internalizing factor predicts mortality risk. Also, while pre-vious studies of mortality risk have emphasized its associations with particular internalizing disorders, no study has assessed how the transdiagnostic internalizing factor vs. disorder-specific variance differently predict that risk. The primary aims of this study were to explore: a) whether the internalizing factor predicts mortality risk, b) whether particular internalizing psychopathologies uniquely predict mortality risk over and beyond the transdiagnostic internalizing factor, and c) whether there is a significant interaction of internalizing with self-reported health in the prediction of mortality risk. We utilized a large national sample of American adults from the Midlife in the United States (MIDUS), a longitudinal study that examined midlife development of individuals across multiple waves between 1995 and 2015. Data were analyzed for the 6,329 participants who completed the phone interview and self-administered questionnaire in MIDUS 1 (1995-1996) and were then followed up until October 31, 2015 or until death. To investigate the association between internalizing and mortality risk, we used the semi-parametric proportional hazards Cox model, where survival time was regressed on a latent internalizing factor. Overall findings indicate that a transdiagnostic internalizing factor significantly predicts mortality risk over a 20-year period (hazard ratio, HR=1.12, 95% CI: 1.05-1.16, p<0.01) and that internalizing outperforms disorder-specific variance (e.g., depression-specific variance) in the prediction of that risk. Further, there was a significant interaction between transdiagnostic internalizing and self-reported health, whereby internalizing psychopathology had a specific association with early death for individuals with excellent self-reported health condition (HR=1.50, 95% CI: 1.17-1.84, p<0.05). This highlights the clinical utility of using the transdiagnostic internalizing factor for prediction of an important future outcome, and supports the argument that internalizing psychopathology can be a meaningful liability to explore in public health practice.
Designing a Successful Primary Care Physician Capitation Model
Authors: Ezekiel J. Emanuel, Farzad Mostashari, Amol S. Navathe
Journal: JAMA (2021)

This Viewpoint proposes 7 elements necessary for a successful transition from a fee-for-service (FFS) to a capitated payment model for primary care physicians, all intended to sustain their ability to improve the quality and value of the care they provide while reducing costs.
Spreading of a new SARS-CoV-2 N501Y spike variant in a new lineage
Authors: Philippe Colson, Anthony Levasseur, Jeremy Delerce, Lucile Pinault, Pierre Dudouet, Christian Devaux, Pierre-Edouard Fournier, Bernard La Scola, Jean-Christophe Lagier, Didier Raoult
Journal: Clinical Microbiology and Infection (2021)
Mammary epithelial cells have lineage-rooted metabolic identities
Authors: Mathepan Jeya Mahendralingam, Hyeyeon Kim, Curtis William McCloskey, Kazeera Aliar, Alison Elisabeth Casey, Pirashaanthy Tharmapalan, Davide Pellacani, Vladimir Ignatchenko, Mar Garcia-Valero, Luis Palomero, Ankit Sinha, Jennifer Cruickshank, Ronak Shetty, Ravi N. Vellanki, Marianne Koritzinsky, Vid Stambolic, Mina Alam, Aaron David Schimmer, Hal Kenneth Berman, Connie J. Eaves, Miquel Angel Pujana, Thomas Kislinger, Rama Khokha
Journal: Nature Metabolism (2021)
KDM6A-ARHGDIB axis blocks metastasis of bladder cancer by inhibiting Rac1
Authors: Lei Liu, Jianfeng Cui, Yajing Zhao, Xiaochen Liu, Lipeng Chen, Yangyang Xia, Yong Wang, Shouzhen Chen, Shuna Sun, Benkang Shi, Yongxin Zou
Journal: Molecular Cancer (2021)

Abstract Background KDM6A, a histone demethylase, is frequently mutated in bladder cancer (BCa). However, the role and detailed molecular mechanism of KDM6A involved in bladder cancer progression remains unknown. Methods Tissue specimens were used to determine the expression levels and prognostic values of KDM6A and ARHGDIB. The MTT, colony formation, wound healing and Transwell migration and invasion assays were employed to detect the BCa cell proliferation, migration and invasion, respectively. Chemotaxis of macrophages was used to evaluate the ability of KDM6A to recruit macrophages. A subcutaneous tumour model and tail vein tumour injection in nude mice were used to assess the role of KDM6A in vivo. RNA sequencing, qPCR, Western blot, ChIP and phalloidin staining assay were performed to investigate the molecular functions of KDM6A. Dual-luciferase reporter assay was used to determine the effects of KDM6A and FOXA1 on the promoters of the ARHGDIB and KDM6A. Results We showed that the KDM6A inhibited the motility and invasiveness of the BCa cells. Mechanistically, KDM6A promotes the transcription of ARHGDIB by demethylating histone H3 lysine di/trimethylation (H3K27me2/3) and consequently leads to inhibition of Rac1. EZH2, which catalyses the methylation of H3K27, functions to silence ARHGDIB expression, and an EZH2 inhibitor can neutralize the metastatic effect caused by KDM6A deficiency. Furthermore, we demonstrated that FOXA1 directly binds to the KDM6A promoter and thus transactivates KDM6A, leading to diminished metastatic potential. Conclusion Our findings establish the critical role of the FOXA1-KDM6A-ARHGDIB axis in restraining the malignancy of BCa and identify KDM6A and EZH2 as potential therapeutic targets in the management of BCa.
Abstract 17488: What Are the Gaps? A Qualitative Study on Patient and Family Decision Making Regarding Implantable Cardioverter Defibrillator and Cardiac Resynchronization Therapy
Authors: Qi Zheng, Sarah Goodlin
Journal: Circulation (2020)

Background: Implantable cardioverter defibrillator (ICD) and cardiac resynchronization therapy (CRT-D) reduce mortality and improve functional status in selected patients with heart failure (HF). However, there are potential procedural risks and psychosocial concerns associated with device implant. This qualitative study aims to explore patients’ and families’ understanding of ICD/CRT-D, heart failure and arrhythmia in the process of decision making regarding device implant. Methods: We conducted 14 focus groups or interviews in Salt Lake City UT and Silver Spring MD. This study included 23 patients, who had either an ICD or CRT-D implant for primary prevention, and 14 family members. Grounded theory analysis was performed to reach a conceptual understanding of patients’ and families’ perceptions and needs. Results: Patients and families largely made decision of ICD/CRT implant based on physicians’ recommendations, e.g. “I really try to do what they tell me to do” (icdpt 1). Patients perceived ICD as lifesaving and CRT being helpful to improve functional status. Many patients described ICD as lifesaving by “restarting a heart if it stops”, while did not understand HF or ventricular arrhythmia. Patients perceived an urgency to consider ICD implant from their physicians, but no such urgency was perceived when they discussed about CRT-D implant. Few participants were concerned with costs, or had knowledge of potential lead malfunction, device removal and associated risks. Many emphasized the importance of information about life expectancies, what HF is, options of different devices, complications and precautions, and what to expect regarding lifestyle changes. Conclusion: Patients and families largely relied on the information provided by physicians and followed physicians’ guidance. They had limited understanding of their prognosis, HF and arrhythmia, and they were motivated to learn. Discussion about devices should include prognosis and healthy life style changes.
Immunogenicity of COVID-19 mRNA Vaccines in Pregnant and Lactating Women
Authors: Ai-ris Y. Collier, Katherine McMahan, Jingyou Yu, Lisa H. Tostanoski, Ricardo Aguayo, Jessica Ansel, Abishek Chandrashekar, Shivani Patel, Esther Apraku Bondzie, Daniel Sellers, Julia Barrett, Owen Sanborn, Huahua Wan, Aiquan Chang, Tochi Anioke, Joseph Nkolola, Connor Bradshaw, Catherine Jacob-Dolan, Jared Feldman, Makda Gebre, Erica N. Borducchi, Jinyan Liu, Aaron G. Schmidt, Todd Suscovich, Caitlyn Linde, Galit Alter, Michele R. Hacker, Dan H. Barouch
Journal: JAMA (2021)

Pregnant women are at increased risk of morbidity and mortality from COVID-19 but have been excluded from the phase 3 COVID-19 vaccine trials. Data on vaccine safety and immunogenicity in these populations are therefore limited.
Efficacy and safety of co-careldopa as an add-on therapy to occupational and physical therapy in patients after stroke (DARS): a randomised, double-blind, placebo controlled trial
Authors: Gary A. Ford, Bipin B. Bhakta, Alastair Cozens, Suzanne Hartley, Ivana Holloway, David Meads, John Pearn, Sharon Ruddock, Catherine M. Sackley, Eirini-Christina Saloniki, Gillian Santorelli, Marion F. Walker, Amanda J. Farrin
Journal: The Lancet (2019)
Salmonella Typhi 감염에 의한 비결석성 급성 담낭염과 급성 간염이 병발된 1예
Authors: 이경태(Kyeong Tae Lee), 양현웅(Hyeon Woong Yang), 서승원(Seung Weon Seo), 성재규(Jae Koo Seong), 이상우(Sang Woo Lee), 이승민(Seung Min Lee), 임의혁(Euyi Hyeog Im), 이병석(Byung Seok Lee), 김남재(Nam Jae Kim), 이현영(Heon Young Lee)
Journal: Clinical and Molecular Hepatology (1999)

Salmonella infection is an acute systemic disease that can lead to diffuse organ involvement with septicemia and cause clinically a variety of complications. But acute acalculous cholecystitis and acute hepatitis with jaundice due to Salmonella typhi occurred rarely. A 42 years old female was admitted with fever, chilling sensation and abdominal pain. On admission, the blood, stool, bile acid and bone marrow cultures were positive for Salmonella typhi. The patient had subsequently developed acute acalculous cholecystitis and acute hepatitis with jaundice. Her symptoms and signs resolved after cholecystostomy, parenteral antibiotic (ciprofloxacin) and supportive treatment. We report a case of acute acalculous cholecystitis and acute hepatitis with jaundice in a 42-year-old female, whose conditions were recovered completely after cholecystostomy and administration of ciprofloxacin, with reviewing the literatures. (Korean J Hepatol 1999;5:148－155)
Innovations in MD-only physician-scientist training: experiences from the Burroughs Wellcome Fund physician-scientist institutional award initiative
Authors: Allison T. McElvaine, Jacqueline A. Hawkins-Salsbury, Vineet M. Arora, Mark T. Gladwin, James R. Goldenring, David P. Huston, Deborah Krakow, Kyu Rhee, Julian Solway, Richard A. Steinman, Dwight A. Towler, Paul J. Utz, Wayne M. Yokoyama, Rolly L. Simpson, Louis J. Muglia, Sallie R. Permar, Rasheed A. Gbadegesin
Journal: Journal of Clinical Investigation (2021)
Abstract 13078: Evaluation of Ventricular Function in Fetus With Transposition of Great Arteries by Velocity Vector Imaging
Authors: Mingxing XIE, Lin Shan, Lv Qing, Wang Jing, Zhang Li, Cao Haiyan, Hong Liu, Li Meng, Song Xiaoyan, Yang Yali
Journal: Circulation (2020)

Background: The aim of this study was to test the hypotheses that (1) fetuses with complete transposition of the great arteries (D-TGA) and Taussig-Bing anomaly (TBA) has decreased the left ventricular (LV) and right ventricular(RV) mechanical function compared with normal fetuses, and (2)the decreased myocardial mechanical function in fetal D-TGA and TBA was associated with the degree of transposition of the great arteries, pulmonary stenosis(PS) and ventricular septal defect(VSD). Methods: We retrospectively identified 49 cases of fetal D-TGA and 29 cases of fetal TBA and compared findings to 49 controls of comparable gestational age. Postprocessing analysis of the left ventricle and right ventricle were done using syngo Velocity Vector Imaging version 2.3. Global and regional longitudinal systolic peak velocity, strain and strain rate were generated. Results: (1) Comparing with control group, the global and regional longitudinal systolic peak velocity (GLV), strain (GLS) and strain rate (GLSR) of the LV and RV were decreased in the group of D-TGA and TBA (P&lt;0.05). (2) In the group of D-TGA and TBA, the multivariate linear regression analysis, the VSD was the independent determinant of LVGLS and RVGLS (β = 0.270, P=0.014 and β = 0.465, P&lt; 0.001). The PS was the independent determinant of RVGLSR (β = 0.090, P=0.009). Conclusion: The ventricular function of fetal D-TGA and TBA were decreased compared with control group. The PS and VSD were the independent determinant factors of the decreased LVGLS, RVGLS and RVGLSR in the fetal D-TGA and TBA.
Abstract 16557: Gender Differences in the One-Year Outcomes of Prasugrel versus Ticagrelor in Acute Myocardial Infarction Treated With Primary Angioplasty: A Posthoc Analysis of the PRAGUE-18 Study
Authors: Petr Kala, Zuzana Motovska, Ota Hlinomaz, Milan Hromadka, Jiri Knot, Ivo Varvarovsky, Jaroslav Dusek, Roman Miklik, Jiri Jarkovsky, Stanislav Simek, Marian Branny, Jan Mrozek, Pavel Cervinka, Jiri Ostransky, Richard Rokyta, Frantisek Tousek, Petr Widimsky
Journal: Circulation (2018)

Introduction: Prasugrel and ticagrelor have shown similar primary net-clinical endpoint (cardiovascular death, spontaneous MI, stroke, severe bleeding or revascularization at day 7) and similar cli...
Human Milk Fortification for Preterm Infants
Authors: Mercedes Pilkington, Belal N. Alshaikh, Mary E. Brindle
Journal: JAMA Pediatrics (2021)

Oft-villainized infant formula has been invited back into the neonatal intensive care unit (NICU) by Chinnappan et al,1 who demonstrate the role of preterm formula (PTF) to supplement, rather than supplant, human milk (HM).
CNP regulates cardiac contractility and increases cGMP near both SERCA and TnI: difference from BNP visualized by targeted cGMP biosensors
Authors: Ornella Manfra, Gaia Calamera, Alexander Froese, Dulasi Arunthavarajah, Nicoletta C Surdo, Silja Meier, Arne Olav Melleby, Monica Aasrum, Jan Magnus Aronsen, Viacheslav O Nikolaev, Manuela Zaccolo, Lise Román Moltzau, Finn Olav Levy, Kjetil Wessel Andressen
Journal: Cardiovascular Research (2021)

Guanylyl cyclase-B (GC-B; natriuretic peptide receptor-B, NPR-B) stimulation by C-type natriuretic peptide (CNP) increases cGMP and causes a lusitropic and negative inotropic response in adult myocardium. These effects are not mimicked by NPR-A (GC-A) stimulation by brain natriuretic peptide (BNP), despite similar cGMP increase. More refined methods are needed to better understand the mechanisms of the differential cGMP signalling and compartmentation. The aim of this work was to measure cGMP near proteins involved in regulating contractility to understand compartmentation of cGMP signalling in adult cardiomyocytes.
Abstract P207: Food Insecurity, Anxiety And Depression In An Underserved Heart Failure Population
Authors: Erin B Clarkson, Stephen Clarkson, Reid Eagleson, Connie White-Williams
Journal: Circulation (2021)

Objective: The HRTSA (HeaRt -Failure Transitional Services for Adults) Clinic at the University of Alabama at Birmingham Hospital serves underinsured individuals with heart failure (HF). We examined the differences in sociodemographic, clinical characteristics, and depression and anxiety among food secure and insecure patients who established care in clinic. Methods: Between May 2018 and December 2019, 291 patients established care in the HRTSA Clinic post-hospitalization. Patients were adults ≥18 years of age with heart failure. At the first clinic visit, baseline sociodemographic and medical history were obtained. Additionally, each patient was screened for depression using the Patient Health Questionaire-9 (PHQ-9) and anxiety using the General Anxiety Disorder-7 (GAD-7) questionnaire. Patients were also screened for food insecurity (FI) using the Hunger Vital Signs screener, a validated 2-item tool created for clinical settings to rapidly identify FI. Using descriptive statistics and t-tests, we compared demographic and clinical characteristics of FI and FS clinic patients. Results: Of the 291 newly referred patients seen in the HRTSA Clinic and screened for food insecurity, the mean age was 50 years, 58% were African American and 29% were female. A total of 80 patients (27%) screened positive for food insecurity. FI patients tended to be female (37% vs 27%, p=0.108) and African American (68% vs. 58%, p=0.142), although not statistically significant. FI patients had statistically significant higher depression scores and had anxiety scores that trended to higher values. Conclusions: Food insecurity, an important social determinant of health, is associated with more depression and anxiety. Depression and anxiety are important contributors to patient-centered outcomes for heart failure patients, specifically in underserved populations. This has implications for health care providers to implement screening interventions to improve mental health in underserved populations.
The sugar content of foods in the UK by category and company: A repeated cross-sectional study, 2015-2018
Authors: Lauren K. Bandy, Peter Scarborough, Richard A. Harrington, Mike Rayner, Susan A. Jebb
Journal: PLoS Medicine (2021)

Background Consumption of free sugars in the UK greatly exceeds dietary recommendations. Public Health England (PHE) has set voluntary targets for industry to reduce the sales-weighted mean sugar content of key food categories contributing to sugar intake by 5% by 2018 and 20% by 2020. The aim of this study was to assess changes in the sales-weighted mean sugar content and total volume sales of sugar in selected food categories among UK companies between 2015 and 2018. Methods and findings We used sales data from Euromonitor, which estimates total annual retail sales of packaged foods, for 5 categories—biscuits and cereal bars, breakfast cereals, chocolate confectionery, sugar confectionery, and yoghurts—for 4 consecutive years (2015–2018). This analysis includes 353 brands (groups of products with the same name) sold by 99 different companies. These data were linked with nutrient composition data collected online from supermarket websites over 2015–2018 by Edge by Ascential. The main outcome measures were sales volume, sales-weighted mean sugar content, and total volume of sugar sold by category and company. Our results show that between 2015 and 2018 the sales-weighted mean sugar content of all included foods fell by 5.2% (95% CI −9.4%, −1.4%), from 28.7 g/100 g (95% CI 27.2, 30.4) to 27.2 g/100 g (95% CI 25.8, 28.4). The greatest change seen was in yoghurts (−17.0% [95% CI −26.8%, −7.1%]) and breakfast cereals (−13.3% [95% CI −19.2%, −7.4%]), with only small reductions in sugar confectionery (−2.4% [95% CI −4.2%, −0.6%]) and chocolate confectionery (−1.0% [95% CI −3.1, 1.2]). Our results show that total volume of sugars sold per capita fell from 21.4 g/d (95% CI 20.3, 22.7) to 19.7 g/d (95% CI 18.8, 20.7), a reduction of 7.5% (95% CI −13.1%, −2.8%). Of the 50 companies representing the top 10 companies in each category, 24 met the 5% reduction target set by PHE for 2018. The key limitations of this study are that it does not encompass the whole food market and is limited by its use of brand-level sales data, rather than individual product sales data. Conclusions Our findings show there has been a small reduction in total volume sales of sugar in the included categories, primarily due to reductions in the sugar content of yoghurts and breakfast cereals. Additional policy measures may be needed to accelerate progress in categories such as sugar confectionery and chocolate confectionery if the 2020 PHE voluntary sugar reduction targets are to be met.
Free Paper Session : Liver Surgery / Basic ; Different risk factors for early and Late recurrence of hepatocellular carcinoma after Living donor Liver transplantation (초)
Authors: Min Su Park, Kwang Woong Lee, Hye Young Kim, Young Rok Choi, Geun Hong, Young Min Jeon, Nam Joon Yi, Kyung Suk Suh
Journal: Clinical and Molecular Hepatology (2011)
Long-term post-COVID symptoms and associated risk factors in previously hospitalized patients: A multicenter study
Authors: César Fernández-de-las-Peñas, Domingo Palacios-Ceña, Víctor Gómez-Mayordomo, Jorge Rodríuez-Jiménez, María Palacios-Ceña, María Velasco-Arribas, Carlos Guijarro, Ana I de-la-Llave-Rincón, Stella Fuensalida-Novo, Carlos M Elvira-Martínez, María L Cuadrado, José A. Arias-Navalón, Lidiane L Florencio, Ricardo Ortega-Santiago, Luis J Molina-Trigueros, Tomas Sebastián-Viana, Juan Torres-Macho, Gabriela Canto-Diez, Susana Plaza-Canteli, Margarita Cigarán-Méndez, Silvia Ambite-Quesada, Valentín Hernández-Barrera, José L Arias-Buría, Lars Arendt-Nielsen
Journal: Journal of Infection (2021)
血管応答増強のためのTaイオン注入ナノリッジプラットフォーム【JST・京大機械翻訳】
Authors: Jang Tae-Sik, Lee Jae Hwan, Kim Sungwon, Park Cheonil, Song Juha, Jae Hwan Jun, Kim Hyoun-Ee, Chung Jin Wook, Jung Hyun-Do
Journal: Biomaterials (2019)
Abstract 16484: Primary Prevention Implantable Cardioverter Defibrillator Utilization for Hypertrophic Cardiomyopathy in US vs Non-US: Findings From the Share Registry
Authors: Victor Nauffal, Peter Marstrand, Larry Han, iacopo olivotto, Adam S Helms, Sara Saberi, Jodie Ingles, Alexandre Pereira, Samuel Wittekind, Euan A Ashley, James S Ware, Michelle Michels, Joseph Rossano, Daniel L Jacoby, Sharlene Day, Carolyn Ho
Journal: Circulation (2020)

Introduction: Risk stratification for sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM) has evolved with notable differences in international practice trends and US vs European guidelines. Hypothesis: Utilization of primary prevention implantable cardioverter defibrillators (ICD) is higher in the US. Methods: We examined rates of primary prevention ICD implantation in 5,063 HCM patients in the international SHaRe registry from 2000 - 2020 (NUS=2,390; Nnon-US=2,673). Using multiple logistic regression we compared probability of ICD implantation for US vs non-US sites adjusting for standard SCD risk factors (Figure 1A). Interaction tests were performed to identify risk factors differentially associated with ICD implantation in US vs non-US sites after 2014 when the European Society of Cardiology (ESC) risk score was introduced. Results: The odds of ICD implantation were 3-fold higher in US sites [ORUS/non-US=3.11 (2.54 -3.81)] (Figure 1A). Odds remained similar after adjustment for ESC risk score [OR =3.17 (2.57 -3.91)]. Implantation rates were higher in the US throughout the study period with a notable drop in rates in both US and non-US sites after 2014 and a reduction in the magnitude of the difference in ICD utilization between US and non-US sites (ORUS/non-US (&lt;2014) =4.20 (3.05-5.78) vs. ORUS/non-US (≥2014)=2.55 (1.89-3.44); pinteraction&lt;0.001) (Figure 1B). Non-sustained ventricular tachycardia was a stronger predictor of ICD implantation in US sites [ORUS=4.9 (3.4-7.0) vs ORnon-US= 2.1 (1.2-3.6); pinteraction=0.005], whereas, left atrial diameter (&gt; 40 mm) was a stronger predictor in non-US sites [ORNon-US=2.9 (2.1-4.0) vs ORUS=1.3 (1-1.6); pinteraction &lt;0.001]. Conclusions: ICD utilization rates vary globally. In this study, primary prevention ICD utilization rates were 3-fold higher in the US despite adjustment for standard SCD risk factors. Further studies are needed to evaluate outcomes of these practice differences.
Attenuated Psychosis Syndrome Should Be Moved to the Main Section in <i>DSM</i>-<i>5</i>-<i>TR</i>
Authors: Cheryl M. Corcoran, Vijay A. Mittal, Scott W. Woods
Journal: JAMA Psychiatry (2021)

This Viewpoint reviews the history of the clinical high risk for psychosis construct, discusses developments from research and clinical practice that inform this dilemma, and argues for including attenuated psychosis syndrome in the main section of the upcoming DSM-5 text revision.