tbuckley/cabot-search huggingface dataset:
Adjuvant oxaliplatin and fall-related injury in patients with colorectal cancer.
Authors: Colin Sue-Chue-Lam, Christine Brezden, Rinku Sutradhar, Amy YX Yu, Nancy N. Baxter
Journal: Journal of Clinical Oncology (2022)

78 Background: Adjuvant oxaliplatin improves colorectal cancer (CRC) survival but causes dose-dependent peripheral neuropathy, possibly increasing the risk of fall-related injuries (FRI) such as fractures. In this retrospective cohort study, we examined the impact of adjuvant oxaliplatin cycles on FRIs. Methods: All data were ascertained from linked health administrative and population databases. We included Ontarians aged 18-85 years at CRC diagnosis between January 1 2007 to December 31 2018 who underwent curative resection and received adjuvant oxaliplatin. We excluded those with a prior cancer diagnosis within 5 years, prior CRC diagnosis ever, non-adenocarcinoma histology, prior oxaliplatin, and &lt;2 years of Ontario health insurance prior to CRC diagnosis. Oxaliplatin dose was determined in the 382 days after resection and dichotomized (1-6 vs. 7-12 cycles). The outcome was FRI, defined by ICD10 codes W00-W19 for any injury caused by a fall requiring emergency or inpatient care. Follow-up began at the end of the treatment window and terminated at the first of FRI, death, loss of Ontario health insurance, or March 31 2020. To account for differences between groups, clinical and demographic characteristics at diagnosis (Table) were used to estimate propensity scores for treatment and calculate inverse probability of treatment weights. These weights were applied to a Fine &amp; Gray regression model to determine the subdistribution hazard ratio (sHR) estimating the association between FRI and 1-6 versus 7-12 cycles of oxaliplatin, with death as a competing risk. Standardized differences &lt;0.1 indicated negligible imbalance. An interaction term tested for effect modification by age at diagnosis. Results: 9,324 patients were included in the study; 1,870 received 1-6 cycles and 7,454 received 7-12 cycles of oxaliplatin. Those exposed to 1-6 cycles were older (61.0 vs. 59.1 years), had higher comorbidity scores (13.5 vs 12.3), and more often had rectal cancer (27.5 vs. 22.2%). Negligible imbalance remained after weighting. Median follow-up was 50.2 months. Total follow-up was 44,472 person-years. There were 1,223 FRIs and 1,913 deaths. The sHR for FRIs comparing 7-12 cycles against 1-6 cycles of oxaliplatin was 0.98 (95% CI 0.85-1.14). The interaction p-value for age and oxaliplatin dose was 0.24. Conclusions: In this population-based retrospective cohort study of 9,324 patients with CRC, the risk of FRIs was similar for 7-12 cycles compared with 1-6 cycles of adjuvant oxaliplatin. This finding was consistent across age at diagnosis. Future research should examine the relationship between oxaliplatin dose and falls not resulting in injury. [Table: see text]
Vaccine certificates: does the end justify the means?
Authors: None The Lancet Microbe
Journal: The Lancet Microbe (2021)

As COVID-19 vaccination programmes proceed in many countries, governments worldwide are considering issuing so-called vaccine certificates to facilitate the re-opening of their stumped economies by easing some restrictions for individuals who have been vaccinated against SARS-CoV-2. But are such certificates justified? Are they likely to be useful? And, most importantly, are they fair?
Editorial: Methoxyflurane nephrotoxicity.
Journal: BMJ (1974)

to which the answers would be largely philosophical.If it is effective when applied to some for short spells it could presumably be much more effective if applied to all for long periods or continuously.That would put decompression in a similar category to the possibility of enhancing cerebral acuity and diminishing risk of infection by living continuously in a sterile chamber of hyperbaric oxygen-scientifically possible but on a commonsense basis nonsensical.For most obstetricians and their patients nature's abhorrence of a vacuum seems likely to prevail.
Inflammopharmacology
Authors: Barbara A. Carlson
Journal: JAMA (1993)

Students of the literature of inflammation and its pharmacological control now have a new international, interdisciplinary journal. Blending several disciplines,<i>Inflammopharmacology</i>reports clinical and experimental research on drugs, their actions, therapeutic efficacy, and safety when used in the treatment of various inflammatory diseases. According to Kluwer's 1992<i>Journals in Medicine</i>catalogue, the journal covers experimental development of in vitro systems and in vivo animal models; assay methodologies; biochemical, immunological, and pharmacological studies; clinical pharmacology and therapeutics; drug-induced side effects; comparative drug studies and trials; and novel approaches toward the therapy of inflammatory conditions. The journal should appeal to both investigators and practitioners. Spearheaded by Rainsford, editorial responsibility lies with 31 experts worldwide. Authors will appreciate the short turnaround time for manuscript review, a month or less from the date of submission. Its refereeing policy is explicitly outlined in the instructions for authors, which speak in defense of anonymous review
Circulating CD137+ T Cells Correlate with Improved Response to Anti-PD1 Immunotherapy in Patients with Cancer
Authors: Ilaria Grazia Zizzari, Alessandra Di Filippo, Andrea Botticelli, Lidia Strigari, Angelina Pernazza, Emma Rullo, Maria Gemma Pignataro, Alessio Ugolini, Fabio Scirocchi, Francesca Romana Di Pietro, Ernesto Rossi, Alain Gelibter, Giovanni Schinzari, Giulia D'Amati, Aurelia Rughetti, Paolo Marchetti, Marianna Nuti, Chiara Napoletano
Journal: Clinical Cancer Research (2022)

Abstract Purpose: CD137 molecule is expressed by activated lymphocytes, and in patients with cancer identifies the tumor-reactive T cells. In solid tumors, high levels of circulating CD137+ T cells are associated with the clinical response and the disease-free status. Here, we examined the role of the CD137+ T cells in the improvement of patients' selection for immunotherapy treatment. Experimental Design: Peripheral blood mononuclear cells derived from 109 patients with metastatic cancer (66 patients for the identification cohort and 43 for the validation cohort) were analyzed for the expression of CD3, CD4, CD8, CD137, and PD1 molecules before the beginning of anti-PD1 therapy. Twenty healthy donors were used as control. The soluble form of CD137 (sCD137) was also analyzed. The CD137+ T cell subsets and the sCD137 were correlated with the clinicopathologic characteristics. The distribution of CD137+ T cells was also examined in different tumor settings. Results: The percentage of CD137+ T cells was higher in healthy donors and in those patients with a better clinical status (performance status = 0–1, n°metastasis≤2) and these high levels were ascribed to the CD8+CD137+ T cell population. The high frequency of CD137+ and CD8+CD137+ T cells resulted as a prognostic factor of overall survival (OS) and progression-free survival (PFS), respectively, and were confirmed in the validation cohort. High levels of CD3+CD137+PD1+ lymphocytes were associated with a low number of metastasis and longer survival. Instead, the high concentration of the immunosuppressive sCD137 in the serum is associated with a lower PFS and OS. In tumor bed, patients with a complete response showed a high percentage of CD137+ and CD8+ T cells. Conclusions: We propose the CD137+ T subset as an immune biomarker to define the wellness status of the immune system for successful anticancer immunotherapy.
PRINTERS AND EDITORS.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Phase II of Combination Daunorubicin and Cytarabine (Ara-C) and Nilotinib (TASIGNA) (DATA) in Patients Newly Diagnosed with Acute Myeloid Leukemia and KIT Expression: Final Results
Authors: Aref Al-Kali, Raoul Tibes, Jeanne Palmer, Hassan B. Alkhateeb, Mrinal M. Patnaik, Kebede H. Begna, Naseema Gangat, Pamela Atherton, Shujun Liu, Rong He, Shahrukh K. Hashmi, Mark R. Litzow
Journal: Blood (2018)
The Lung
Authors: Richard L. Reece
Journal: JAMA (1968)

What sort of organ is the lung? A difficult question, but as Averill Liebow, co-editor of this volume, says, it is "... much more than a wind bag or bellows. It is a complicated, subtle and important chemical system of which the activities have been only partly revealed." This monograph, the eighth put out by the International Academy of Pathology, helps to reveal a little more. Doctors Liebow and Smith have gathered together 24 authorities to give their views of what goes on in the labyrinths of the lung. The first 15 chapters concern the living lung and cover topics like pulmonary dynamics, respiratory surfaces, mechanical properties, changes in disease, cellular population, responses to environment, and comparisons to diseases in animals. Next come four chapters on geographic pathology, and pathologists from different lands participate. An Egyptian has a go at pulmonary bilharziasis, a Peruvian at the lungs of high-altitude dwellers, a
Mitoxantrone, Etoposide, and Cytarabine (MEC) Following Epigenetic Priming with Decitabine in Adults with Relapsed/Refractory Acute Myeloid Leukemia (AML) or High-Risk Myelodysplastic Syndrome (MDS): Final Results from a Phase 1/2 Study
Authors: Anna B. Halpern, Sarah A. Buckley, Megan Othus, Emily M Huebner, Kaysey F. Orlowski, Bart L Scott, Andrea M. Perdue, Heather A. Smith, Pamela S. Becker, Paul C. Hendrie, Stephanie Cassone, Tara L. Chen, Derek L. Stirewalt, Elihu H. Estey, Roland B. Walter
Journal: Blood (2016)
Growing up in the shadow of COVID-19
Authors: None The Lancet Child & Adolescent Health
Journal: The Lancet Child & Adolescent Health (2020)

8 months into the pandemic, the UK Government's inadequate consideration of young people in the COVID-19 response is causing lasting harm to a whole generation. Although children and adolescents are generally less clinically vulnerable to COVID-19 than are adults, the wider effects of COVID-19 policies have disproportionately and negatively affected the young.
THE USELESS CORONER.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Retracted: Immunoglobulin G4+ B‐cell receptor clones distinguish immunoglobulin G4‐related disease from primary sclerosing cholangitis and biliary/pancreatic malignancies
Journal: Hepatology (2022)

Retraction Retracted: Immunoglobulin G4+ B‐cell receptor clones distinguish immunoglobulin G 4‐related disease from primary sclerosing cholangitis and biliary/pancreatic malignancies Doorenspleet, Marieke E.; Hubers, Lowiek M.; Culver, Emma L.; Maillette de Buy Wenniger, Lucas J.; Klarenbeek, Paul L.; Chapman, Roger W.; Baas, Frank; van de Graaf, Stan F.; Verheij, Joanne; van Gulik, Thomas M.; Barnes, Eleanor; Beuers, Ulrich; de Vries, Niek Hepatology. 64(2):501-507, July 21, 2016.
Department of Error
Authors: Nicholas Wald, Walter Willett
Journal: The Lancet (2004)

In this Article (May 24), the second and third sentences of the third paragraph of the Results section should have read: "The database contained 53 patients with one exposure to SARS over a limited time scale with recorded start and end dates.The maximum likelihood estimate of the mean and variance of the time from infection to onset was 3•81 days (95% CI 3•00-4•92) and 8•34 days, 2 respectively; therefore 95% of patients were estimated to experience the onset of symptoms within 9•45 days of infection."Panel A of figure 2 was also incorrect.The correct version appears below.
Self-Monitoring of Blood Glucose
Journal: Diabetes Care (1985)

Self-monitoring of blood glucose is an increasingly used adjunct to diabetes care. Meticulous technique for visual comparisons and reflectance meters are mandatory. The data collected in this manner must be used for therapeutic decisions if SMBG is to aid the person with diabetes. Self-monitoring of blood glucose, if prescribed by the physician, becomes part of routine clinical treatment for insulin-dependent and non-insulin-dependent diabetes and therefore should be paid by the usual payment mechanisms.
Highlights From the Circulation Family of Journals
Authors: Julian Chun, Stefano Bordignon, Jana Last, Lukas Mayer, Shota Tohoku, Simone Zanchi, Lorenzo Bianchini, Fabrizio Bologna, Takahiko Nagase, Lukas Urbanek, Shaojie Chen, Boris Schmidt, Yixuan Ye, Xi Chen, James Han, Wei Jiang, Pradeep Natarajan, Hongyu Zhao, Taku Omori, Goki Uno, Shunsuke Shimada, Florian Rader, Robert Siegel, Takahiro Shiota, Jeehoon Kang, Kyung Park, Hak Lee, Chengbin Zheng, Tae-Min Rhee, You-Jeong Ki, Mineok Chang, Jung-Kyu Han, Han-Mo Yang, Hyun-Jae Kang, Bon-Kwon Koo, Hyo-Soo Kim, Sergio Leonardi, Mattia Branca, Anna Franzone, Eugene Mcfadden, Raffaele Piccolo, Peter Jüni, Pascal Vranckx, Philippe Steg, Patrick Serruys, Edouard Benit, Christoph Liebetrau, Luc Janssens, Maurizio Ferrario, Aleksander Zurakowski, Roberto Diletti, Marcello Dominici, Kurt Huber, Ton Slagboom, Pawel Buszman, Leonardo Bolognese, Carlo Tumscitz, Krzysztof Bryniarski, Adel Aminian, Mathias Vrolix, Ivo Petrov, Scot Garg, Cristoph Naber, Janusz Prokopczuk, Christian Hamm, Dik Heg, Stephan Windecker, Marco Valgimigli, Hasina Maredia, Mary Bowring, Allan Massie, Sunjae Bae, Amber Kernodle, Shakirat Oyetunji, Christian Merlo, Robert Higgins, Dorry Segev, Errol Bush
Journal: Circulation (2021)

This month's Highlights from the subspecialty journals covers techniques for atrial fibrillation ablation, the impact of lifestyle on polygenic risk scores for cardiovascular risk factors, a novel approach to grading tricuspid regurgitation, the interplay of clinical and procedural risk for coronary interventions, an analysis of the accuracy of outcomes ascertainment, and disparities for Black heart transplant recipients.A randomized trial published in Circulation Arrhythmia and Electrophysiology showed that cryoballoon ablation led to significantly shorter procedure times compared with laser balloon ablation with similar efficacy.A UK Biobank analysis from Circulation: Genomic and Precision Medicine suggests that a healthy lifestyle significantly mitigates the cardiovascular risk associated with high polygenic risk scores.From Circulation: Cardiovascular Imaging, a vena contracta >14 mm may identify a higher-risk subset among patients with severe tricuspid regurgitation.An analysis comparing the impact of clinical risk factors with procedural risk factors after coronary interventions is presented in Circulation: Cardiovascular Interventions.GLASSY, a substudy of the GLOBAL-LEADERS trial (A Clinical Study Comparing Two Forms of Anti-platelet Therapy After Stent Implantation), demonstrates the importance and feasibility of event adjudication compared with investigator reporting in Circulation: Cardiovascular Quality and Outcomes.
Kingdom-Wide Analysis of Fungal Protein-Coding and tRNA Genes Reveals Conserved Patterns of Adaptive Evolution
Authors: Rhondene Wint, Asaf Salamov, Igor V Grigoriev
Journal: Molecular Biology and Evolution (2022)

Protein-coding genes evolved codon usage bias due to the combined but uneven effects of adaptive and nonadaptive influences. Studies in model fungi agree on codon usage bias as an adaptation for fine-tuning gene expression levels; however, such knowledge is lacking for most other fungi. Our comparative genomics analysis of over 450 species supports codon usage and transfer RNAs (tRNAs) as coadapted for translation speed and this is most likely a realization of convergent evolution. Rather than drift, phylogenetic reconstruction inferred adaptive radiation as the best explanation for the variation of interspecific codon usage bias. Although the phylogenetic signals for individual codon and tRNAs frequencies are lower than expected by genetic drift, we found remarkable conservation of highly expressed genes being codon optimized for translation by the most abundant tRNAs, especially by inosine-modified tRNAs. As an application, we present a sequence-to-expression neural network that uses codons to reliably predict highly expressed transcripts. The kingdom Fungi, with over a million species, includes many key players in various ecosystems and good targets for biotechnology. Collectively, our results have implications for better understanding the evolutionary success of fungi, as well as informing the biosynthetic manipulation of fungal genes.
Books Received
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Table of contents
Authors: Melissa Mauskar, Kalyani Marathe, Aruna Venkatesan, Bethanee Schlosser, Libby Edwards, Dirk Elston, Warren Heymann, Brian Kim, Kang Sun, Kim Papp, May Venturanza, Adnan Nasir, Michael Kuligowski, David Pariser, Jerry Bagel, Mark Lebwohl, Gil Yosipovitch, Elaine Chien, Mary Spellman, Brandon Kirsch, Stacy Smith, Joel Cohen, Janet Dubois, Lawrence Green, Leslie Baumann, Neal Bhatia, Ping-Yu Liu, Deepak Chadha, Patricia Walker, Jonathan Silverberg, Eric Simpson, Jashin Wu, Laurent Eckert, Isabelle Guillemin, Zhen Chen, Marius Ardeleanu, Ashish Bansal, Mandeep Kaur, Ana Rossi, Neil Graham, Naimish Patel, Abhijit Gadkari, Maria Schneeweiss, Jennifer Huang, Richard Wyss, Sebastian Schneeweiss, Joseph Merola, Carmen Montagnon, Elizabeth Fracica, Archna Patel, Michael Camilleri, M Murad, David Dingli, David Wetter, Stanislav Tolkachjov, Joy Wan, Junko Takeshita, Daniel Shin, Joel Gelfand, Prakash Acharya, Mahesh Mathur, Khalaf Kridin, Payal Patel, Virginia Jones, Adriana Cordova, Kyle Amber, Emily Baumrin, Soraya Azzawi, Jessica St, Mai John, Steven Hoang, Camden Chen, Daniela Bay, Sheila Shaigany, Alexa Steuer, Nicole Seminara, Nooshin Brinster, Alisa Femia, Ayelet Ollech, Rame Yousif, Lacey Kruse, Annette Wagner, Brandi Kenner-Bell, Sarah Chamlin, Duri Yun, Lisa Shen, Karina Vivar, Megan Reynolds, Amy Paller, Anthony Mancini, Angela Patrı, Lucia Gallo, Maria Guarino, Gabriella Fabbrocini, Reid Oldenburg, Amanda Marsch, Esther Freeman, Devon Mcmahon, Teresa Oranges, Agata Janowska, Valentina Dini
Journal: Journal of the American Academy of Dermatology (2020)
Molecular Biology and Pathology of Lymphangiogenesis
Authors: Terhi Karpanen, Kari Alitalo
Journal: Annual Review of Pathology Mechanisms of Disease (2007)

The lymphatic vasculature is essential for the maintenance of tissue fluid balance, immune surveillance, and adsorption fatty acids in the gut. The lymphatic vessels are also crucially involved in the pathogenesis of diseases such as tumor metastasis, lymphedema, and various inflammatory conditions. Attempts to control or treat these diseases have drawn a lot of interest to lymphatic vascular research during the past few years. Recently, several markers specific for lymphatic endothelium and models for lymphatic vascular research have been characterized, enabling great technical progress in lymphatic vascular biology, and many critical regulators of lymphatic vessel growth have been identified. Despite these significant achievements, our understanding of the lymphatic vessel development and pathogenesis is still rather limited. Several key questions remain to be resolved, including the relative contributions of different pathways targeting lymphatic vasculature, the molecular and cellular processes of lymphatic maturation, and the detailed mechanisms of tumor metastasis via the lymphatic system.