tbuckley/cabot-search huggingface dataset:
Association between early graft patency and late outcome for patients undergoing artery bypass graft surgery.
Authors: B LGould, P DClayton, R LJensen, H VLiddle
Journal: Circulation (1984)

For a group of 658 patients who received coronary artery bypass graft surgery, we investigated the correlation between the degree of early (6 months) graft patency and recurrence of anginal symptoms, late myocardial infarction, and postoperative coronary-related death. The patients were grouped according to the number of surgically placed grafts, and each group was further subgrouped on the basis of the number of grafts functioning at the early postsurgical follow-up examination. The patients were observed over a period as long as 13 years. The frequency with which angina returned correlated significantly with the degree of patency within each of the groups (one, two, three, or four grafts); patients with a higher percentage of patent grafts experienced longer periods of freedom from angina. On the average, patients with all of their multiple grafts patent experienced at least 7 more years of symptomatic relief than their counterparts with all grafts occluded. Most surprisingly, the rate of the return of ...
Cutaneous and muscular rasodilation in the canine hindlimb evoked by central stimulation.
Authors: W JLang, CBell, E LConway, RPadanyi
Journal: Circulation Research (1976)

Using stereotaxic procedures, we electrically stimulated specific sites in the hypothalamus and midbrain of anesthetized dogs pretreated with guanethidine and atropine methonitrate. A tract in which stimulation caused noncholinergic dilator responses in the hindlimbs was identified. The course of this trace was different from that subserving cholinergic vasodilation in the hindlimb musculature. In a number of experiments we studied the proportional distribution of blood flow to leg and paw. Responses restricted to the paw were regarded as occurring mainly in cutaneous vessels; those restricted to the leg were regarded as occurring mainly in the skeletal muscle vessels. Some dilator responses in both beds were abolished by intra-arterial administration of antihistamines: other dilator responses were abolished by intra-arterial injections of dopamine antagonists. Centrally evoked dilation of leg and paw vessels by noncholinergic pathways suggests physiological roles for these fibers in the regulation of car...
Ultrasonic duplex scanning for disease of the carotid artery.
Authors: GFell, D JPhillips, P MChikos, J DHarley, B LThiele, D EStrandness
Journal: Circulation (1981)

The duplex ultrasonic scanner combines real-time B-mode imaging with a single-gate, variable-range pulsed Doppler. The detection and categorization of the severity of carotid artery atherosclerosis is achieved by performing spectral analysis of the pulsed Doppler velocity signal obtained from vessels of interest. Using this technique, 750 patients with suspected extracranial carotid artery disease were evaluated between January 1978 and January 1980. One hundred thirty-five of these 750 patients (18%) underwent cerebral arteriography performed with biplanar views of the carotid bifurcation. The degree of stenosis was measured independently in these patients and was available for comparison with the results of duplex scanning and spectral analysis. Duplex scanning correctly detected the presence of disease in 252 of 259 carotid arteries studied (97%). The extent of involvement varied from plaques that produced less than 10% diameter reduction to those that resulted in a total occlusion. The technique was l...
Monitoring Warfarin Therapy in Patients with Lupus Anticoagulants
Authors: Armando D'Angelo
Journal: Annals of Internal Medicine (1998)

Letters15 March 1998Monitoring Warfarin Therapy in Patients with Lupus AnticoagulantsArmando D'Angelo, MD, Patrizia Della Valle, PhD, and Luciano Crippa, MDArmando D'Angelo, MDScientific Institute H.S. Raffaele; 20132 Milano, ItalySearch for more papers by this author, Patrizia Della Valle, PhDScientific Institute H.S. Raffaele; 20132 Milano, ItalySearch for more papers by this author, and Luciano Crippa, MDScientific Institute H.S. Raffaele; 20132 Milano, ItalySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-6-199803150-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Moll and Ortel report that the use of the international normalized ratio (INR) to standardize prothrombin times is invalid for some patients with lupus anticoagulants, who should be individually monitored with a test that is insensitive to lupus anticoagulants [1]. Their conclusions support our suggestion that monitoring of oral anticoagulation with prothrombin time in patients with lupus anticoagulants should be performed at high plasma dilutions to avoid unnecessary excessive anticoagulation for patients who may have major bleeding complications [2]. In a series of 10 patients with persistent lupus anticoagulants and venous thromboembolic disease who had been treated ...References1. Moll S, Ortel TL. Monitoring warfarin therapy in patients with lupus anticoagulants. Ann Intern Med. 1997; 127:177-85. Google Scholar2. Della Valle P, Crippa L, Safa O, Tomassini L, Pattarini E, Vigano' D'Angelo S, et al. Potential failure of the international normalized ratio (INR) system in the monitoring of oral anticoagulation in patients with lupus anticoagulants. Ann Med Interne. 1996; 147(Suppl 1):10-4. Google Scholar3. Owren PA, Aas K. The control of dicoumarol therapy and the quantitative determination of prothrombin and proconvertin. Scand J Clin Lab Invest. 1951; 3:201-8. Google Scholar4. Simioni P, Prandoni P, Zanon E, Saracino MA, Scudeller A, Villalta S, et al. Deep venous thrombosis and lupus anticoagulant. A case–control study. Thromb Haemost. 1996; 76:187-9. Google Scholar5. Lockshin MD. Answers to the antiphospholipid-antibody syndrome? N Engl J Med. 1995; 332:1025-7. Google Scholar Author, Article, and Disclosure InformationAffiliations: Scientific Institute H.S. Raffaele; 20132 Milano, Italy PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 March 1998Volume 128, Issue 6Page: 504KeywordsAnticoagulant therapyAnticoagulantsBlood plasmaHemorrhageInternational normalized ratioProthrombin timeResearch laboratoriesVenous thromboembolism Issue Published: 15 March 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Anchored Proximmally Migrated Pancreatic Stent: Endoscopic Technical Tips for Extraction
Authors: L Zabalza, V Ubieto, D Martínez de Acitores, V Busto, V Jusue, J Carrascosa, S Lopez, I Fernandez Urien, JJ Vila
Journal: Endoscopy (2021)

Internal migration of pancreatic stents (IMPS) occurs in 5 % of cases with successful endoscopic removal in 80 %. A 31 yo male who suffered IMPS, was referred to our centre after several retrieval attempts. Pancreatography showed ductal stenosis distally to the IMPS. After dilatation of the stenosis, the IMPS was grasped using the Lasso technique, but it was fixed to the pancreatic duct for a calcification precluding removal. After several unsuccessful maneouvers, a second stent was placed in order to break the anchoring calcification, which was confirmed in a subsequent ERCP. The Lasso technique was completed and the IMPS retrieved.
Calcium homeostasis in rabbit ventricular myocytes. Disruption by hypochlorous acid and restoration by dithiothreitol.
Authors: D WEley, BKorecky, HFliss, MDésilets
Journal: Circulation Research (1991)

Hypochlorous acid (HOCl) is a toxic oxidant produced by neutrophils at sites of cardiac inflammation. To examine the effect of this oxidant on Ca2+ homeostasis in the heart, isolated rabbit ventricular myocytes were iontophoretically loaded with the Ca2+ indicator fura 2 and superfused with 100 microM HOCl under voltage-clamp conditions. Ca2+ transients and the corresponding Ca2+ currents were elicited by 300-msec depolarizing pulses from -40 to 0 mV. Within 200 seconds after HOCl addition, the amplitude of the Ca2+ transients was reduced from 402 +/- 89 to 82 +/- 29 nM (p less than 0.01) while intracellular free ([Ca2+]i increased from 78 +/- 16 to 265 +/- 48 nM (p less than 0.01). During this time, the amplitude of the slow inward currents increased by 10%, while steady-state holding current remained stable. This sustained steady-state rise in [Ca2+]i occurred even in the absence of extracellular Ca2+ but was virtually abolished by a 20-second preexposure to 10 mM caffeine, suggesting that the major sou...
Isoform distribution and tissue contents of contractile and cytoskeletal proteins in hypertrophied smooth muscle from rat portal vein.
Authors: UMalmqvist, AArner
Journal: Circulation Research (1990)

Growth of the smooth muscle in the rat portal vein was initiated by an increased transmural pressure. After 7 days, the cross-sectional area of the vessel wall and the maximal active force of the longitudinal muscle layer had increased twofold. Electron microscopy showed that the cell cross-sectional area was increased, suggesting cellular hypertrophy. Increased amounts of intermediate (10 nm) filaments were observed in the hypertrophied cells. The hypertrophied vessels had decreased DNA content per unit wet weight compared with the control vessels (hypertrophied, 1.5 +/- 0.1; control, 1.9 +/- 0.1 micrograms/mg; p less than 0.01). Protein composition was studied with electrophoretic methods. Compared with control preparations the hypertrophied veins had similar myosin and actin contents per unit wet weight (myosin: hypertrophied, 4.4 +/- 0.8; control, 5.9 +/- 0.9; actin: hypertrophied 12.2 +/- 0.6; control, 11.8 +/- 1.0 mg/g). Two different forms of the myosin heavy chain were detected with 5% sodium dode...
The Management of Infectious Diseases in Clinical Practice.
Journal: Annals of Internal Medicine (1983)

The other chapters discuss in much the same way complement, polymorph nuclear leucocytes, lymphocyte populations, macrophages and immunogenetics and their relation to chronic rheumatic disease.This book is really a review for the specialist with an immunological bias engaged in rheumatology research, who requires a very good update in the relevant immunology, rather than a text for practising physicians.My impression is that the rheumatologist, who thinks of the patient as the centre of his attention rather than of immunological explanations, will be bemused, just like renaissance man, when he was informed that Copernicus had proven that the sun no longer moved round the earth.
Effects of hydralazine on coronary blood flow and myocardial energetics in congestive heart failure.
Authors: R DMagorien, G PBrown, D VUnverferth, SNelson, HBoudoulas, DBambach, C VLeier
Journal: Circulation (1982)

The acute effects of oral hydralazine, 1 mg/kg, on coronary vascular resistance, coronary blood flow (estimated using the coronary sinus thermodilution technique), and myocardial oxygen consumption were evaluated in 10 patients with chronic (New York Heart Association class III and IV) nonischemic congestive heart failure. Central hemodynamic responses demonstrated a modest decrease in mean arterial pressure, pulmonary capillary wedge pressure and systemic vascular resistance (12%, 15% and 29%, respectively), while the cardiac index increased from 2.3 +/- 0.1 to 3.1 +/- 0.3 and left ventricular stroke work index from 24 +/- 3.7 to 28 +/- 3.4 (p less than 0.01). Heart rate and diastolic filling time did not change. Coronary blood flow increased approximately 50%, from 144 +/- 17 to 218 +/- 30 ml/min, and coronary vascular resistance decreased from 0.55 +/- 0.09 to 0.36 +/- 0.08 mm Hg/ml/min (both p less than 0.01). Oral hydralazine increased myocardial oxygen consumption by 33%, from 15 +/- 1.6 to 20 +/- 2...
Ultraconserved enhancer function does not require perfect sequence conservation
Authors: Valentina Snetkova, Athena R. Ypsilanti, Jennifer A. Akiyama, Brandon J. Mannion, Ingrid Plajzer-Frick, Catherine S. Novak, Anne N. Harrington, Quan T. Pham, Momoe Kato, Yiwen Zhu, Janeth Godoy, Eman Meky, Riana D. Hunter, Marie Shi, Evgeny Z. Kvon, Veena Afzal, Stella Tran, John L. R. Rubenstein, Axel Visel, Len A. Pennacchio, Diane E. Dickel
Journal: Nature Genetics (2021)
Noninvasive estimation of valve area in patients with aortic stenosis by Doppler ultrasound and two-dimensional echocardiography.
Authors: TSkjaerpe, LHegrenaes, LHatle
Journal: Circulation (1985)

In 30 patients with aortic stenosis, 14 of whom also had significant aortic regurgitation, the velocities in the stenotic jet (V') and below the valve (V) were recorded by Doppler ultrasound. With two-dimensional echocardiography, two subvalvular areas (A) were calculated from leading-to-leading edge (large) and trailing-to-leading edge (inner) diameter measurements. The aortic valve area was calculated by the equation of continuity (A' = A X peak V/peak V') and by calculating stroke volume below the valve [A X integral of V (t) and dividing by the integral of V' (t) (= A). Based on cardiac output estimations from single-plane angiographic images, Gorlin's formula was used to calculate invasive valve areas. In patients with no or mild aortic regurgitation a second invasive estimate was based on cardiac output measured by the Fick method. The best correlation was found when A' (with large diameter) was compared with invasive results based on cardiac output measured by the Fick method (r = .89, SEE +...
Postischemic myocardial "stunning". Identification of major differences between the open-chest and the conscious dog and evaluation of the oxygen radical hypothesis in the conscious dog.
Authors: J FTriana, X YLi, UJamaluddin, J IThornby, RBolli
Journal: Circulation Research (1991)

Recent studies suggest that oxygen-derived free radicals contribute to the pathogenesis of postischemic myocardial dysfunction (myocardial stunning). This concept, however, is predicated exclusively on results obtained in open-chest preparations, which are subject to the confounding influence of many unphysiological conditions. The lack of supporting evidence in more physiological animal models represents a major persisting limitation of the oxy-radical hypothesis of myocardial stunning. The goal of this study was to address two fundamental (and related) questions: 1) Does the open-chest animal model alter the phenomenon of myocardial stunning? 2) If so, how valid are the concepts, derived from such a model, regarding the pathogenetic role of oxy-radicals? In part 1 of the study, myocardial stunning after a 15-minute coronary occlusion was compared in 30 pentobarbital-anesthetized open-chest dogs and in 19 conscious dogs. For any given level of collateral flow during occlusion, the recovery of systolic ...
Impact of finite orifice size on proximal flow convergence. Implications for Doppler quantification of valvular regurgitation.
Authors: LRodriguez, JAnconina, F AFlachskampf, A EWeyman, R ALevine, J DThomas
Journal: Circulation Research (1992)

Analysis of velocity acceleration proximal to a regurgitant valve has been proposed as a method to quantify the regurgitant flow rate (Qo). Previous work has assumed inviscid flow through an infinitesimal orifice, predicting hemispheric isovelocity shells, with calculated flow rate given by Qc = 2 pi rN2vN, where vN is user-selected velocity of interest and rN is the distance from that velocity to the orifice. To validate this approach more rigorously and investigate the impact of finite orifice size on the assumption of hemispheric symmetry, numerical and in vitro modeling was used. Finite-difference modeling demonstrated hemispheric shape for contours more than two orifice diameters from the orifice. More proximal than this (where the measured velocity vN exceeded 3% of the orifice velocity vo), flow was progressively underestimated, with a proportional error delta Q/Qo nearly identical to the ratio of contour velocity to orifice velocity, vN/vo. For the in vitro investigations, flow rates from 4.3 to 1...
Shall The Journal be Removed to Washington?
Authors: C. R. Earley
Journal: JAMA (1891)

<h3>To the Editor:</h3> —I can see no reason why the location of The Journal should be changed from where it now is and has been so long published, and as I believe, to the best interests of the Medical profession. Chicago is nearer the centre of the United States, and why removeThe Journal? I think it far better for the Medical profession to advocate less change in our associations, rules, and regulations, and stand firmly together as a band of brothers and frown upon all movements to create " isms" and " cisms" that tend to weaken and destroy the old landmarks of the profession. Ridgway, Pa., March 17, 1891.
Comment on Grimaldi et al. Association of Obstructive Sleep Apnea in Rapid Eye Movement Sleep With Reduced Glycemic Control in Type 2 Diabetes: Therapeutic Implications. Diabetes Care 2014;37:355–363
Authors: Simone Scarlata, Raffaele Antonelli-Incalzi
Journal: Diabetes Care (2014)

We read with great interest the article by Grimaldi et al. (1) focusing on how rapid eye movement (REM) sleep deprivation due to obstructive sleep apnea affects glycemic control in type 2 diabetes. The study meritoriously investigates the effect of continuous positive airway pressure (CPAP) on HbA1c levels. However, selected limitations deserve to be cited. Indeed, the authors aimed at determining the metabolic effect of reversing apneas by calculating the mean profiles of cumulative minutes of REM and non-REM (NREM) …
13N ammonia myocardial imaging at rest and with exercise in normal volunteers. Quantification of absolute myocardial perfusion with dynamic positron emission tomography.
Authors: JKrivokapich, G TSmith, S CHuang, E JHoffman, ORatib, M EPhelps, H RSchelbert
Journal: Circulation (1989)

Positron emission tomography (PET) was applied to the measurement of myocardial perfusion using the perfusion tracer 13N-labeled ammonia. 13N ammonia was delivered intravenously to 13 healthy volunteers both at rest and during supine bicycle exercise. Dynamic PET imaging was obtained in three cross-sectional planes for 10 minutes commencing with each injection. The left ventricle was divided into eight sectors, and a small region of interest was assigned to the left ventricular blood pool to obtain the arterial input function. The net extraction of 13N ammonia was obtained for each sector by dividing the tissue 13N concentration at 10 minutes by the integral of the input function from the time of injection to 10 minutes. With this approach for calculating net extractions, rest and exercise net extractions were not significantly different from each other. To obviate possible overestimation of the true 13N ammonia input function by contamination by 13N-labeled compounds other than 13N ammonia or by spillove...
Pulsus alternans determined by biventricular simultaneous systolic time intervals.
Authors: YHada, CWolfe, ECraige
Journal: Circulation (1982)

This investigation was performed to determine the presence of unilateral or bilateral pulsus alternans in the systemic and pulmonary circulations in heart failure and to estimate the prevalence of pulsus alternans in congestive cardiomyopathy. The subjects were 36 adult patients in heart failure due to a variety of cardiopulmonary diseases. We measured left- and right-sided systolic time intervals from simultaneous dual echocardiograms of both semilunar valves. The alternans was left-sided in seven patients, right-sided in one patient and bilateral in six patients. Pulsus alternans was induced by ventricular premature complexes (VPCs), except in one patient with bilateral and persistent alternans. For a VPC to precipitate alternans, the early beat itself must be associated with an abbreviated ejection time. Echophonocardiographic records of 100 patients with congestive cardiomyopathy were reviewed for evidence of pulsus alternans. We found persistent alternans in 10 patients and VPC-induced alternans in s...
Accuracy of electronic digital calipers compared with quantitative angiography in measuring coronary arterial diameter.
Authors: AUehata, TMatsuguchi, J ABittl, JOrav, I TMeredith, T JAnderson, A PSelwyn, PGanz, A CYeung
Journal: Circulation (1993)

BACKGROUNDQuantitative angiography is the accepted method for measuring coronary luminal diameter. Electronic digital calipers have been used to assess arterial diameters in vasomotor function studies and after interventional procedures. However, careful validation of calipers against quantitative angiography has not been described.METHODS AND RESULTSWe used digital calipers and quantitative angiography to measure 517 arterial diameters (88 nonstenotic segments) in 24 transplant patients undergoing vasomotor function studies with acetylcholine and nitroglycerin, 20 stenoses in 14 patients with coronary artery disease, and 15 stenoses in 15 patients before and after excimer laser-facilitated coronary angioplasty and at 6 months' follow-up. In nonstenotic arterial segments ranging in size from 0.6 to 3.5 mm, calipers overestimated diameters measured by quantitative angiography by 0.29 +/- 0.21 mm (mean +/- SD) (limits of agreement, -0.13 to 0.71 mm). However, when the vasomotor responses were expressed as p...
Alternate ventriculoatrial Wenckebach conduction.
Authors: SLevy, RRoudaut, EBouvier, I WObel, JClementy, HBricaud
Journal: Circulation (1980)

Three cases are presented showing retrograde alternate Wenckebach periods. Retrograde alternate Wenckebach periods were defined as 2:1 ventriculoatrial (VA) block in which the conducted beats showed progressive prolongation of conduction (VA) time. The sequence terminates with two or three successively blocked ventricular beats. In one of the three cases the level of block was identified as being in the atrioventricular (AV) node. In the other two the level of block could not be clearly identified. This report provides further evidence for the concept of multilevel block within the AV node. Retrograde alternate Wenckebach periods may explain some instances of variation of atrial depolarization intervals during episodes of ventricular tachycardia and may be clinically significant.
<i>QuickStats:</i> Emergency Department Visit Rates* Related to Mental Health Disorders,<sup>†</sup> by Age Group and Sex — National Hospital Ambulatory Medical Care Survey, United States,<sup>§</sup> 2016–2018
Authors: Loredana Santo, Zachary Peters, Carol Defrances
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

44 45-64 ≥65 Annual visits per 1,000 people Age group (yrs) Overall Female Male * Visit rates are based on the July 1, 2016-July 1, 2018, estimates of the civilian noninstitutionalized population as developed by the U.S. Census Bureau Population Division; 95% confidence intervals are indicated with error bars.† Visits related to mental health disorder are defined as all emergency department visits with any listed diagnosis of a mental health disorder, International Classification of Diseases, Tenth Revision, Clinical Modification codes F01-F99.§ Based on a sample of visits to emergency departments in noninstitutional general and short-stay hospitals, exclusive of federal, military, and Veterans Administration hospitals, that are located in the 50 states and the District of Columbia.During 2016-2018, there were 43.9 emergency department visits per 1,000 persons per year with a diagnosis of a mental health disorder.Rates were lowest among children and adolescents aged <18 years (12.8) and highest for adults aged 18-44 years (64.9).Rates declined with age for adults aged 18-44 to ≥65 years (32.2).Overall and for each age group, there were no statistically significant differences by sex.