Development and Validation of a Modified Full Age Spectrum Creatinine-Based Equation to Estimate Glomerular Filtration Rate
Authors: Emmanuelle Vidal-Petiot, Jimmy Mullaert, Nahid Tabibzadeh, Martin Flamant
Journal: Annals of Internal Medicine (2021)

LettersJuly 2021Development and Validation of a Modified Full Age Spectrum Creatinine-Based Equation to Estimate Glomerular Filtration RateEmmanuelle Vidal-Petiot, MD, PhD, Jimmy Mullaert, MD, PhD, Nahid Tabibzadeh, MD, PhD, Martin FlamantEmmanuelle Vidal-Petiot, MD, PhDAssistance Publique-Hôpitaux de Paris, Bichat Hospital, and Université de Paris, INSERM U1149, Paris, FranceSearch for more papers by this author, Jimmy Mullaert, MD, PhDAssistance Publique-Hôpitaux de Paris, Bichat Hospital, and Université de Paris, UMR 1137 IAME, INSERM, Paris, FranceSearch for more papers by this author, Nahid Tabibzadeh, MD, PhDAssistance Publique-Hôpitaux de Paris, Bichat Hospital, and Université de Paris, UMR S1138, Cordeliers Research Center, Paris, FranceSearch for more papers by this author, Martin FlamantAssistance Publique-Hôpitaux de Paris, Bichat Hospital, and Université de Paris, INSERM U1149, Paris, FranceSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L21-0247 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR: Pottel and colleagues (1) have developed a new equation to estimate glomerular filtration rate (GFR) across the full age spectrum. One major improvement is that this equation, known as the European Kidney Function Consortium (EKFC) equation, smooths estimated GFR (eGFR) across the transition from adolescence to adulthood. In adults, the main conceptual difference compared with previous equations is a threshold for the age parameter using a coefficient of 0.990(Age − 40) only in patients older than 40 years. Indeed, this equation substantially improves GFR estimation in young adults compared with the Chronic Kidney Disease Epidemiology Collaboration equation, ...References1. Pottel H, Björk J, Courbebaisse M, et al. Development and validation of a modified full age spectrum creatinine-based equation to estimate glomerular filtration rate. A cross-sectional analysis of pooled data. Ann Intern Med. 2021;174:183-91. [PMID: 33166224]. doi:10.7326/M20-4366 LinkGoogle Scholar2. Pottel H, Hoste L, Yayo E, et al. Glomerular filtration rate in healthy living potential kidney donors: a meta-analysis supporting the construction of the full age spectrum equation. Nephron. 2017;135:105-19. [PMID: 27764827] doi:10.1159/000450893 CrossrefMedlineGoogle Scholar3. Levey AS, Coresh J, Tighiouart H, et al. Measured and estimated glomerular filtration rate: current status and future directions. Nat Rev Nephrol. 2020;16:51-64. [PMID: 31527790] doi:10.1038/s41581-019-0191-y CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Assistance Publique-Hôpitaux de Paris, Bichat Hospital, and Université de Paris, INSERM U1149, Paris, FranceAssistance Publique-Hôpitaux de Paris, Bichat Hospital, and Université de Paris, UMR 1137 IAME, INSERM, Paris, FranceAssistance Publique-Hôpitaux de Paris, Bichat Hospital, and Université de Paris, UMR S1138, Cordeliers Research Center, Paris, FranceAssistance Publique-Hôpitaux de Paris, Bichat Hospital, and Université de Paris, INSERM U1149, Paris, FranceDisclosures: Authors have reported no disclosures of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L21-0247. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDevelopment and Validation of a Modified Full Age Spectrum Creatinine-Based Equation to Estimate Glomerular Filtration Rate Hans Pottel , Jonas Björk , Marie Courbebaisse , Lionel Couzi , Natalie Ebert , Björn O. Eriksen , R. Neil Dalton , Laurence Dubourg , François Gaillard , Cyril Garrouste , Anders Grubb , Lola Jacquemont , Magnus Hansson , Nassim Kamar , Edmund J. Lamb , Christophe Legendre , Karin Littmann , Christophe Mariat , Toralf Melsom , Lionel Rostaing , Andrew D. Rule , Elke Schaeffner , Per-Ola Sundin , Stephen Turner , Arend Bökenkamp , Ulla Berg , Kajsa Åsling-Monemi , Luciano Selistre , Anna Åkesson , Anders Larsson , Ulf Nyman , and Pierre Delanaye Development and Validation of a Modified Full Age Spectrum Creatinine-Based Equation to Estimate Glomerular Filtration Rate Hans Pottel and Pierre Delanaye Metrics July 2021Volume 174, Issue 7Page: 1037-1038KeywordsAdolescentsAttentionChildrenChronic kidney diseaseCreatinineEpidemiologyGlomerular filtration rateKidneysPopulation statisticsYoung adults ePublished: 20 July 2021 Issue Published: July 2021 Copyright & PermissionsCopyright © 2021 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...