tbuckley/cabot-search huggingface dataset:
Double-Balloon Enteroscopy-Facilitated Ischaemic Polypectomy Of Small-Bowel Polyps In Patients With Peutz-Jeghers Syndrome
Authors: A Skamnelos, A Murino, N Lazaridis, E Vlachou, N Koukias, R Chacchi Cahuin, SL Walton, R Raymond, EJ Despott
Journal: Endoscopy (2021)

Ischaemic-polypectomy with detachable-snares or endoclips at double-balloon enteroscopy (DBE) is emerging as a promising technique for the minimally-invasive management of small-bowel polyps in patients with Peutz-Jeghers syndrome (PJS).
Experiences at a Federally Qualified Health Center Support Expanded Conception of the Gifts of Precision Medicine
Authors: Carolyn P. Neuhaus, Johanna Tayloe Crane
Journal: The American Journal of Bioethics (2021)

This article is referred to by:Response to Open Peer Commentaries: Distinguishing the "Gift" from "Donation" as a Path toward Reciprocity and Relational Ethics
Diagnosis of ventricular septal defect by pulsed Doppler echocardiography. Sensitivity, specificity and limitations.
Authors: J GStevenson, IKawabori, TDooley, W GGuntheroth
Journal: Circulation (1978)

The M-mode echocardiographic findings of ventricular septal defect (VSD) are nonspecific. A specific pulsed Doppler echocardiographic (PDE) diagnosis of VSD can be made by following the turbulent VSD jet through the septum. To assess the sensitivity, specificity and limitations of PDE diagnosis of VSD, 105 children undergoing cardiac catheterization were examined by PDE. These children had a variety of cardiac defects, and a PDE diagnosis of VSD was made in 46/51 (90%) who had VSD proven at catheterization. There was one false positive PDE diagnosis of VSD, for a specificity of 98%. Factors influencing the ability to diagnose VSD by PDE include the location of the defect, level of pulmonary vascular resistance and direction of blood flow through the VSD. The presence of additional defects did not interfere with PDE diagnosis of VSD. The PDE detection of additional defects may identify situations where M-mode echocardiographic estimation of dimensions may not be indicative of the size of VSD shunt.
Post-myocardial infarction exercise testing. Non-Q wave versus Q wave correlation with coronary angiography and long-term prognosis.
Authors: C PMiranda, W GHerbert, PDubach, K GLehmann, V FFroelicher
Journal: Circulation (1991)

BACKGROUNDThe presence or absence of baseline diagnostic Q waves has been believed to compromise the accuracy of standard exercise electrocardiography in identifying severe coronary artery disease (three-vessel and/or left main disease); therefore, a retrospective analysis was performed using a personal computer data base of exercise test responses and cardiac catheterization results to evaluate this premise, and follow-up was performed to observe how Q waves and/or severe coronary disease impacted on survival.METHODS AND RESULTSTwo hundred fifty-three male patients who had survived a myocardial infarction were studied. Patients on digitalis, those with left bundle branch block or left ventricular hypertrophy on their baseline electrocardiogram, those with previous revascularization procedures, and those with significant valvular or congenital heart disease were excluded. All patients performed either a low-level predischarge or a sign/symptom limited exercise test and underwent diagnostic coronary angiog...
Hypertension in Young Adults and Subsequent Cardiovascular Disease
Authors: Ivan de Kouchkovsky, Jacob Mayfield, Jeffrey Kohlwes
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Noninvasive stress testing. Methodology for elimination of the phonocardiogram.
Authors: D HSpodick, V QLance
Journal: Circulation (1976)

Measurement by systolic time intervals (STI) of cardiac responses requires extremely careful recording during actual stress test performance. Previous work indicated no significant changes in the pulse transmission time (PTT) during exercise and other challenges. Since external STI depend on the carotid pulse offset by the PTT as an aortic curve equivalent, stable PTT implies that timing of the carotid upstroke (CARu) and the carotid incisura (CARIN) would respectively track the pre-ejection period (i.e., the externally calculated onset of the aortic upstroke) and the aortic incisura which is externally timed by the aortic component of SII (IIA). In ten subjects, STIs were recorded at supine rest, sitting, standing, during prompt and sustained squatting and during isometric and dynamic exercise. The results demonstrated the tracking of both points: regression slopes and correlation coefficients were close to 1.00 for each series and for each subset. Coefficients of correlation (r) and of determination (r2...
Technical Outcomes And Risk Of Stricture After Endoscopic Submucosal Dissection For Large Colorectal Lesions
Authors: R Maselli, M Spadaccini, PA Galtieri, G Pellegatta, EC Ferrara, A Fugazza, S Carrara, A Anderloni, A Repici
Journal: Endoscopy (2021)

Aims Endoscopic submucosal dissection(ESD)is a well-established approach for the minimally invasive treatment of colorectal(CR)neoplasia. Although technical improvements enable en-bloc removal of large circumferential and near-circumferential rectal lesions, the efficacy and safety outcomes, have only been described in few Eastern countries’ experiences. The aim of this study is to assess efficacy and safety outcomes of a cohort of patients treated with ESD for large rectal lesions in a tertiary Western center, with a particular focus on the risk of stricture.
From the authors
Authors: J. Hansen, X-G. Sun, K. Wasserman
Journal: European Respiratory Journal (2006)

We welcome the comments of J. Vandevoorde and M. Swanney, who have been at the forefront of advocacy for the substitution of forced expiratory volume in six seconds (FEV6) and its ratios for forced vital capacity (FVC) and its ratios. While we respect their findings, our study 1 concerned the use of spirometry to detect airway obstruction in a relatively healthy population, the third National Health and Nutrition Evaluation Survey (NHANES-III), rather than its clinical use in following patients with known disease.

We hope we agree that in following patients with known and significant airway obstruction or in assessing responsiveness to inhaled bronchodilators, the absolute values of FEV1 or FEV3 are optimal, and ratios such as FEV1/FEV6, FEV1/FVC or mean forced expiratory flow between 25 and 75% of FVC (FEF25–75%) are not. In following these patients, there is no need for repeated lengthy forced manoeuvres, such as FEV6 or FVC. Unforced vital capacities not only suffice, but may be more informative and less stressful than repeated FEV6 or …
Effects of quinidine on action potentials and ionic currents in isolated canine ventricular myocytes.
Authors: J JSalata, J AWasserstrom
Journal: Circulation Research (1988)

We examined the effects of quinidine (5-20 microM) on transmembrane action potentials and ionic currents of isolated canine ventricular myocytes. Collagenase treatment of canine ventricular tissue produced a yield of 40-60% healthy cells. Myocytes had normal resting and action potentials as measured using conventional microelectrodes. Quinidine decreased Vmax, amplitude, overshoot, and the duration of action potentials stimulated by passage of brief current pulses through the recording pipette. Recovery was complete after washout except that action potential duration was prolonged compared with control. A discontinuous single microelectrode voltage (switch) clamp was used to measure ionic currents. Quinidine irreversibly reduced steady-state outward current as measured with three different voltage clamp protocols. Quinidine reversibly decreased peak calcium current as well as the slowly inactivating and/or steady-state inward currents in the plateau voltage range, presumably both late sodium (tetrodot...
Variation in European antibiotic use [5] (multiple letter)
Authors: S Coenen, M M Kuyenhoven, C C Butler, P Van Royen, Verheij Tjm., H A Thiadens, C Ros, D S Postma, G A Van Essen, I M Gould, R Clarke, S Hutchinson, P Davey
Journal: The Lancet (2001)
Associations between attainment of incentivised primary care indicators and emergency hospital admissions among type 2 diabetes patients: a population-based historical cohort study
Authors: Laura H Gunn, Ailsa J McKay, Mariam Molokhia, Jonathan Valabhji, German Molina, Azeem Majeed, Eszter P Vamos
Journal: Journal of the Royal Society of Medicine (2021)

England has invested considerably in diabetes care over recent years through programmes such as the Quality and Outcomes Framework and National Diabetes Audit. However, associations between specific programme indicators and key clinical endpoints, such as emergency hospital admissions, remain unclear. We aimed to examine whether attainment of Quality and Outcomes Framework and National Diabetes Audit primary care diabetes indicators is associated with diabetes-related, cardiovascular, and all-cause emergency hospital admissions.Historical cohort study.A total of 330 English primary care practices, 2010-2017, using UK Clinical Practice Research Datalink.A total of 84,441 adults with type 2 diabetes.The primary outcome was emergency hospital admission for any cause. Secondary outcomes were (1) diabetes-related and (2) cardiovascular-related emergency admission.There were 130,709 all-cause emergency admissions, 115,425 diabetes-related admissions and 105,191 cardiovascular admissions, corresponding to unplanned admission rates of 402, 355 and 323 per 1000 patient-years, respectively. All-cause hospital admission rates were lower among those who met HbA1c and cholesterol indicators (incidence rate ratio = 0.91; 95% CI 0.89-0.92; p < 0.001 and 0.87; 95% CI 0.86-0.89; p < 0.001), respectively), with similar findings for diabetes and cardiovascular admissions. Patients who achieved the Quality and Outcomes Framework blood pressure target had lower cardiovascular admission rates (incidence rate ratio = 0.98; 95% CI 0.96-0.99; p = 0.001). Strong associations were found between completing 7-9 (vs. either 4-6 or 0-3) National Diabetes Audit processes and lower rates of all admission outcomes (p-values < 0.001), and meeting all nine National Diabetes Audit processes had significant associations with reductions in all types of emergency admissions by 22% to 26%. Meeting the HbA1c or cholesterol Quality and Outcomes Framework indicators, or completing 7-9 National Diabetes Audit processes, was also associated with longer time-to-unplanned all-cause, diabetes and cardiovascular admissions.Attaining Quality and Outcomes Framework-defined diabetes intermediate outcome thresholds, and comprehensive completion of care processes, may translate into considerable reductions in emergency hospital admissions. Out-of-hospital diabetes care optimisation is needed to improve implementation of core interventions and reduce unplanned admissions.
Action potential propagation in a thick strand of cardiac muscle.
Authors: B JRoth
Journal: Circulation Research (1991)

A theoretical model of action potential propagation in a thick strand of cardiac muscle is presented. The calculation takes into account the anisotropic and syncytial properties of the tissue, the presence of the interstitial space, the effect of the surrounding tissue bath, and the variation of the potential both along the strand length and across the strand cross section. The bidomain model is used to represent the electrical properties of the tissue, and the Ebihara-Johnson model is used to represent the properties of the active sodium channels. The calculated wave front is curved, with the action potential at the surface of the strand leading that at the center. The rate of rise of the action potential and the time constant of the action potential foot vary with depth into the tissue. The velocity of the wave front is nearly independent of strand radius for radii greater than 0.5 mm. The conduction velocity decreases as the volume fraction of the interstitial space decreases. In the limit of tightly p...
A computer study of the left ventricular performance based on fiber structure, sarcomere dynamics, and transmural electrical propagation velocity.
Authors: RBeyar, SSideman
Journal: Circulation Research (1984)

A model of the left ventricle which combines a spheroidal geometry with a spatial fiber angle distribution is presented. The mechanics of each muscle fiber is described by its passive stress-strain relationship, active stress-strain relationship, and an activation function (half a sinusoid) which represents the time-dependent degree of activation of the fiber. A stress-strain rate relationship which characterizes the muscle fibers is used to calculate the mechanics of left ventricular contraction during ejection. Furthermore, a radial electrical signal propagation from the endocardium to the epicardium is used here as a first approximation to the actual depolarization sequence. The model is used to describe the process of contraction throughout the systole. The different calculated parameters and indices of left ventricular function are presented and discussed for different preloading, afterloading and contractility conditions. The maximum elastance is found to be an optimal macroscale parameter of contra...
Solving Two Problems With One Look: Successful Diagnosis of an Indeterminate Biliary Stricture and Removal of a Migrated Biliary Stent By Cholangioscopy
Authors: C O’Neill, T Bana e Costa, J Neves, P Queirós, C Chagas
Journal: Endoscopy (2021)

57-years-old man with obstructive jaundice. Abdominal-CT identified two biliary strictures. ERCP performed for plastic stent placement and cytology of the stricture(negative). During subsequent ERCP the stent fragmented and was not retrieved. Cholangioscopy with SpyGlassDS revealed: migrated stent fragment in right hepatic duct, CBD stenosis with ulceration and a vegetative lesion, suspicious for malignancy(biopsies showed low-grade-dysplasia). The stent was captured using the SpyGlass Snare. Due to high endoscopic suspicion, performed right hepatectomy confirmed Klatskin tumour.
Immediate enhancement of left ventricular relaxation by coronary artery bypass grafting: intraoperative assessment.
Authors: L SHumphrey, E JTopol, G IRosenfeld, A MBorkon, W ABaumgartner, T JGardner, GMaruschak, J LWeiss
Journal: Circulation (1988)

We investigated the effect of coronary artery bypass grafting on the rate of left ventricular relaxation as defined by the time constant for isovolumetric relaxation, T, measured in milliseconds. Completeness of relaxation at rapid heart rates was determined by comparison of the relationship between left ventricular pressure and echocardiographic left ventricular cross-sectional cavity area during rapid ventricular pacing with that obtained after a prolonged diastole when the ventricle was maximally relaxed. Twelve patients with coronary artery disease had significantly higher T values (94.5 +/- 6.2) than six patients without coronary artery disease who were undergoing other open heart procedures (39.5 +/- 5.0, p less than .001). T was significantly reduced after coronary artery bypass grafting (68.2 +/- 5.1, p = .007), but was unchanged in the six control patients after cardiopulmonary bypass (37.8 +/- 4.5, p = .54). Similar changes were found during rapid pacing to 100, 120, and 140/min. Incomplete rela...
Screening for Colorectal Cancer
Authors: David S. Weinberg, Robert E. Schoen
Journal: Annals of Internal Medicine (2014)

This issue provides a clinical overview of Screening for Colorectal Cancer focusing on prevention, diagnosis, treatment, practice improvement, and patient information. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including ACP Smart Medicine and MKSAP (Medical Knowledge and Self-Assessment Program). Annals of Internal Medicine editors develop In the Clinic from these primary sources in collaboration with the ACP's Medical Education and Publishing divisions and with the assistance of science writers and physician writers. Editorial consultants from ACP Smart Medicine and MKSAP provide expert review of the content. Readers who are interested in these primary resources for more detail can consult <url>http://smartmedicine.acponline.org</url>, <url>http://mksap.acponline.org</url>, and other resources referenced in each issue of In the Clinic.
Role of ATP-sensitive potassium channels in coronary microvascular autoregulatory responses.
Authors: TKomaru, K GLamping, C LEastham, K CDellsperger
Journal: Circulation Research (1991)

The purpose of the present study was to test the hypothesis that ATP-sensitive potassium channels mediate autoregulatory vasodilatation of coronary arterioles in vivo. Experiments were performed in 23 open-chest anesthetized dogs. Coronary arterial microvascular diameters were directly measured with fluorescence microangiography using an intravital microscope and stroboscopic epi-illumination synchronized to the cardiac cycle. A mild coronary stenosis (perfusion pressure = 60 mm Hg), a critical coronary stenosis (perfusion pressure = 40 mm Hg), and complete coronary artery occlusion were produced with an occluder around the left anterior descending coronary artery in the presence or absence of glibenclamide (10(-5) M, topically), which inhibits ATP-sensitive potassium channels, or of vehicle. During topical application of vehicle (0.01% dimethyl sulfoxide), there was dilatation of small (less than 100 microns diameter) arterioles during reductions in perfusion pressure (percent change in diameter: 6.7 +/-...
As others see us: views from abroad: A social experiment that keeps adapting
Authors: P. J McDonald
Journal: BMJ (1998)

Australia's health system has its historical origins in the United Kingdom. Up until the implementation of the NHS, the Australian healthcare system mirrored the British system. The General Medical Council of Great Britain accredited Australian medical schools until the Australian Medical Council was formed in the 1980s; Australian postgraduate medical training is provided through “royal colleges”; the Australian Medical Association emerged out of the BMA in the 1960s; the public health and hospital systems of Australia are modelled on their British counterparts; and the overall organisation of health services revolves around the pivotal role of the general practitioner.



Promoting access to essential health services: a tram advertises Glasgow's campaign against TB



Formation of the NHS was a defining event for Australian health because of the Australian decision not to follow Britain into a nationalised health system. Though Australian health systems are built on the British model, they have evolved into an Australian version that is currently known as Medicare. The principles of Medicare are similar to those that underlie the NHS—namely, equitable access of all citizens to government funded quality health care—but the current Australian systems of healthcare organisation and funding bear little resemblance to the NHS. In Australia most medical services are provided by private general practitioners and specialists on a fee for service basis that is …
Formation of S-adenosylhomocysteine in the heart. I: An index of free intracellular adenosine.
Authors: ADeussen, MBorst, JSchrader
Journal: Circulation Research (1988)

To assess the concentration of free intracellular adenosine in the heart the kinetic properties of cytosolic S-adenosylhomocysteine (SAH) hydrolase were utilized at elevated levels of L-homocysteine (adenosine + L-homocysteine in equilibrium with SAH + H2O). Global hypoxia was induced in the isolated perfused guinea pig heart by graded reduction of perfusion medium PO2 in the presence of saturating concentrations of homocysteine (0.2-1.0 mM). Reduction of PO2 from 660 to 165 mm Hg increased the steady-state concentration of total tissue adenosine from 2.0 +/- 0.2 to 2.8 +/- 0.2 nmoles/g, while the rate of SAH formation increased linearly from 0.22 +/- 0.03 to 2.50 +/- 0.13 nmoles/min/g. When adenosine was exogenously applied at a concentration of 100 microM together with homocysteine (1 mM), SAH accumulation rates were much greater: 23.34 +/- 3.31 and 42.11 +/- 1.73 nmoles/min/g with normoxic (95% O2) and hypoxic (30% O2) perfusion, respectively. The apparent Km and Vmax values for SAH-hydrolase in vivo w...
Stereoscopic Manual of the Ocular Fundus in Local and Systemic Disease
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal