tbuckley/cabot-search huggingface dataset:
Racial and Ethnic Disparities in Breastfeeding Initiation ─ United States, 2019
Authors: Katelyn V. Chiang, Ruowei Li, Erica H. Anstey, Cria G. Perrine
Journal: MMWR Morbidity and Mortality Weekly Report (2021)

Breastfeeding is the optimal source of nutrition for most infants (1).Although breastfeeding rates in the United States have increased during the past decade, racial/ethnic disparities persist (2).Breastfeeding surveillance typically focuses on disparities at the national level, because small sample sizes limit examination of disparities at the state or territorial level.However, birth certificate data allow for assessment of breastfeeding initiation among nearly all newborn infants in the United States both nationally and at the state and territorial levels.To describe breastfeeding initiation by maternal race/ethnicity,* CDC analyzed 2019 National Vital Statistics System (NVSS) birth certificate data for 3,129,646 births from 48 of the 50 states (all except California and Michigan † ), the District of Columbia (DC), and three U.S. territories (Guam, Northern Mariana Islands, and Puerto Rico).The prevalence of breastfeeding initiation was 84.1% overall and varied by maternal race/ethnicity, ranging from 90.3% among infants of Asian mothers to 73.6% among infants of Black mothers, a difference of 16.7 percentage points.Across states, the magnitude of disparity between the highest and lowest breastfeeding rates by racial/ethnic groups varied, ranging from 6.6 percentage points in Vermont to 37.6 percentage points in North Dakota, as did the specific racial/ethnic groups with the highest and lowest rates.These state/territory-specific data highlight the variation that exists in breastfeeding disparities across the United States and can help public health practitioners and health departments identify groups on which to focus efforts.Targeting breastfeeding promotion programs on populations with lower breastfeeding rates might help reduce racial/ethnic disparities in breastfeeding initiation and improve infant nutrition and health.* All racial/ethnic groups are non-Hispanic unless otherwise noted.† California does not report breastfeeding initiation data to NVSS.Michigan uses nonstandard wording for the breastfeeding initiation item on the birth certificate,which prevents comparison of data to other states.Birth data from NVSS are a census of all live births in the United States collected by using the U.S. Standard Certificate of Live Birth.§ Birth certificate data include an infant nutrition item, determined from medical records, that indicates whether an infant received any breast milk or colostrum during the period between delivery and hospital discharge (3).¶ Data also include self-reported maternal race/ethnicity.** ,† † Analysis § https://www.cdc.gov/nchs/data/dvs/birth11-03final-ACC.pdf¶ Analyses were not limited to births occurring in hospitals.NVSS provides birth certificate completion instructions to facilities, but breastfeeding information is also collected for births occurring in other locations (e.g., freestanding birth centers, clinics, doctors' offices, and homes) via the birth certificate.
Molecular Imaging of Inflammation and Fibrosis in Pressure Overload Heart Failure
Authors: Aylina Glasenapp, Katja Derlin, Marcel Gutberlet, Annika Hess, Tobias L. Ross, Hans-Jürgen Wester, Frank M. Bengel, James T. Thackeray
Journal: Circulation Research (2021)

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Enhanced HbF reactivation by multiplex mutagenesis of thalassemic CD34+ cells in vitro and in vivo
Authors: Nikoletta Psatha, Aphrodite Georgakopoulou, Chang Li, Vivek Nandakumar, Grigorios Georgolopoulos, Reyes Acosta, Kiriaki Paschoudi, Jemma Nelson, Daniel Chee, Anastasia Athanasiadou, Anastasia Kouvatsi, Alister Peter William Funnell, André Lieber, Evangelia Yannaki, Thalia Papayannopoulou
Journal: Blood (2021)
POS1090 ASSOCIATION BETWEEN ANTIBIOTIC USE AND KNEE PAIN AND FUNCTION IN OA: DATA FROM THE OSTEOARTHRITIS INITIATIVE
Authors: I. Shirinsky, V. Zagainova, V. Shirinsky
Journal: Annals of the Rheumatic Diseases (2021)

Background: Recently, gut dysbiosis has been linked with joint pain in osteoarthritis (OA) (1). Thus, it can be hypothesized that antibiotic use impacts symptoms of OA. To date, there have been no studies assessing association between the intake of antibiotics and clinical manifestations of knee OA. Objectives: To evaluate association between the use of antibiotics and OA-related knee pain and function. Methods: For the current study we used 4-year longitudinal data obtained from the Osteoarthritis Initiative (OAI) progression (n= 1390) and incidence (n = 3284) subcohorts, which are publically available at https://oai.nih.gov . The outcome variables studied were Western Ontario McMaster Osteoarthritis Index (WOMAC) pain and function subscales. To acquire information about the use of antibiotics, a medication inventory method was used. We excluded participants who used antibiotics at or 30 days prior to baseline (a “new-user” design). Antibiotic users were defined as those with at least one recorded use during first four years of the study. The participants were matched into antibiotic users/non-users pairs using genetic matching based on various demographic and clinical characteristics. The outcomes were assessed at baseline and annually until year 4. Generalized estimating equations (GEE) were used to model the relationship between outcomes and antibiotic use by time interaction. Results: A total of 515 new antibiotic users were matched with 515 non-users. After matching, all standardized differences of means were less than 0.05 indicating that covariates were well balanced between groups. No association between the use of antibiotic and changes in WOMAC pain and function scores was found (Table 1). No associations were also observed in multiple stratified analyses based on different duration of antibiotic use, particular classes of antibiotics, or different baseline WOMAC pain or disability levels. Table 1. Longitudinal analysis (with treatment*time interaction) of WOMAC subcategories and antibiotics use β coefficient 95% CI P value WOMAC Pain -0.008 (-0.08 to 0.07) 0.8 WOMAC Function -0.014 (-0.24 to 0.21) 0.9 Conclusion: These findings do not support the effects of antibiotics on knee OA pain or disability. More research is needed on the role of microbiota and its modulation in OA. References: [1]Boer, C.G., Radjabzadeh, D., Medina-Gomez, C. et al. Intestinal microbiome composition and its relation to joint pain and inflammation. Nat Commun 10, 4881 (2019). https://doi.org/10.1038/s41467-019-12873-4 Disclosure of Interests: None declared.
Brain glycogen serves as a critical glucosamine cache required for protein glycosylation
Authors: Ramon C. Sun, Lyndsay E.A. Young, Ronald C. Bruntz, Kia H. Markussen, Zhengqiu Zhou, Lindsey R. Conroy, Tara R. Hawkinson, Harrison A. Clarke, Alexandra E. Stanback, Jessica K.A. Macedo, Shane Emanuelle, M. Kathryn Brewer, Alberto L. Rondon, Annette Mestas, William C. Sanders, Krishna K. Mahalingan, Buyun Tang, Vimbai M. Chikwana, Dyann M. Segvich, Christopher J. Contreras, Elizabeth J. Allenger, Christine F. Brainson, Lance A. Johnson, Richard E. Taylor, Dustin D. Armstrong, Robert Shaffer, Charles J. Waechter, Craig W. Vander Kooi, Anna A. DePaoli-Roach, Peter J. Roach, Thomas D. Hurley, Richard R. Drake, Matthew S. Gentry
Journal: Cell Metabolism (2021)
Advances in coatings on magnesium alloys for cardiovascular stents – A review
Authors: Zhao-Qi Zhang, Yong-Xin Yang, Jing-An Li, Rong-Chang Zeng, Shao-Kang Guan
Journal: Bioactive Materials (2021)

Magnesium (Mg) and its alloys, as potential biodegradable materials, have drawn wide attention in the cardiovascular stent field because of their appropriate mechanical properties and biocompatibility. Nevertheless, the occurrence of thrombosis, inflammation, and restenosis of implanted Mg alloy stents caused by their poor corrosion resistance and insufficient endothelialization restrains their anticipated clinical applications. Numerous surface treatment tactics have mainly striven to modify the Mg alloy for inhibiting its degradation rate and enduing it with biological functionality. This review focuses on highlighting and summarizing the latest research progress in functionalized coatings on Mg alloys for cardiovascular stents over the last decade, regarding preparation strategies for metal oxide, metal hydroxide, inorganic nonmetallic, polymer, and their composite coatings; and the performance of these strategies in regulating degradation behavior and biofunction. Potential research direction is also concisely discussed to help guide biological functionalized strategies and inspire further innovations. It is hoped that this review can give assistance to the surface modification of cardiovascular Mg-based stents and promote future advancements in this emerging research field.
The association between inhaled corticosteroid and osteoporosis and fracture
Authors: Cheng-Yi Wang, Chih-Cheng Lai
Journal: European Respiratory Journal (2021)

We read with great interest the study investigating the association between inhaled corticosteroid (ICS) and the risk of osteoporosis and fracture among COPD patients [1]. Multivariate analysis in this study demonstrated a significant dose–effect relationship between ICS and the risk of osteoporosis-related events. Compared to non-ICS users, high-dose ICS treatment was significantly associated with any osteoporosis-related event (risk ratio 1.52, 95% CI 1.24–1.62; while the corresponding estimate for low-dose ICS was 1.27, 95% CI 1.13–1.56) [1]. Overall, it is a well-designed study; however, we have one major and two minor concerns about the findings of this study. More analysis is needed to assess the impact of inhaled corticosteroid on osteoporosis <https://bit.ly/3u7qzpg>
Expression of interleukin-13 receptors and their targeting in animal models of human ovarian cancer
Authors: Mitomu Kioi, Mariko Kawakami, Satoru Takahashi, Koji Kawakami, Raj K. Puri
Journal: Cancer Research (2005)

5012  We have previously reported that human ovarian cancer cell lines express interleukin (IL)-13 receptors (R). However, the incidence, and significance of IL-13R expression in human ovarian cancer specimens is not known. Ovarian cancer tissue samples were investigated for the expression of IL-13R in situ. Immunohistochemical analysis revealed that approximately 32% of 22 ovarian cancer specimens and 34% of 32 ovarian cancer tissue array samples express IL-13Rα2, a high affinity IL-13 receptor, at high intensity. On the other hand, normal ovary tissue samples (n=16) expressed none or low level of IL-13Rα2 chain. Similarly, IL-13Rα2 expression in malignant ovarian tumors was significantly higher compared to benign ovarian tumor tissues (p
Virtual and in-person cardiac rehabilitation
Authors: Hasnain M Dalal, Patrick Doherty, Sinead TJ McDonagh, Kevin Paul, Rod S Taylor
Journal: BMJ (2021)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Virtual and in-person cardiac rehabilitation Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Prior COVID-19 protects against reinfection, even in the absence of detectable antibodies
Authors: Aodhán Seán Breathnach, Christopher James Arthur Duncan, Kate El Bouzidi, Aidan Taeke Hanrath, Brendan Alexander Ingelby Payne, Paul Anthony Randell, Maximillian Shahin Habibi, Peter Andrew Riley, Timothy David Planche, John Samuel Busby, Malur Sudhanva, Scott John Charles Pallett, William Peter Kelleher
Journal: Journal of Infection (2021)
T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours
Authors: Stefanie Lesch, Viktoria Blumenberg, Stefan Stoiber, Adrian Gottschlich, Justyna Ogonek, Bruno L. Cadilha, Zahra Dantes, Felicitas Rataj, Klara Dorman, Johannes Lutz, Clara H. Karches, Constanze Heise, Mathias Kurzay, Benjamin M. Larimer, Simon Grassmann, Moritz Rapp, Alessia Nottebrock, Stephan Kruger, Nicholas Tokarew, Philipp Metzger, Christine Hoerth, Mohamed-Reda Benmebarek, Dario Dhoqina, Ruth Grünmeier, Matthias Seifert, Arman Oener, Öykü Umut, Sandy Joaquina, Lene Vimeux, Thi Tran, Thomas Hank, Taisuke Baba, Duc Huynh, Remco T. A. Megens, Klaus-Peter Janssen, Martin Jastroch, Daniel Lamp, Svenja Ruehland, Mauro Di Pilato, Jasper N. Pruessmann, Moritz Thomas, Carsten Marr, Steffen Ormanns, Anna Reischer, Michael Hristov, Eric Tartour, Emmanuel Donnadieu, Simon Rothenfusser, Peter Duewell, Lars M. König, Max Schnurr, Marion Subklewe, Andrew S. Liss, Niels Halama, Maximilian Reichert, Thorsten R. Mempel, Stefan Endres, Sebastian Kobold
Journal: Nature Biomedical Engineering (2021)
POS1397 HYDROXYCHLOROQUINE INDUCED RETINAL TOXICITY IN PATIENTS WITH RHEUMATIC DISEASES
Authors: R. Maheshwari, R. Sankaralingam, S. Chinnadurai, J. Antony, B. Chilukuri, M. Mani
Journal: Annals of the Rheumatic Diseases (2021)

Background: Retinal toxicity from hydroxychloroquine (HCQ) is rare, but the vision loss maybe irreversible and could have medicolegal consequences. Objectives: To determine the prevalence and assess the predictors of retinal toxicity due to HCQ in patients with rheumatic diseases. There is paucity of literature on retinal toxicity due to HCQ in rheumatic diseases. Methods: A retrospective observational study was conducted in the Department of Clinical Immnuology and Rheumatology, Sri Ramachandra Institute of Higher Education and Research,Chennai, India from November 2018-May 2020, on patients taking HCQ for more than 6 months. All patients underwent ophthalmological screening at baseline and every 6 months, and thereafter by modern day screening methods-Humphrey Visual Field (HVF)10-2, Spectral Domain Optical Coherence Tomography(SD-OCT), except for patients with evidence of suspected retinal toxicity at baseline.Fundus autofluorescence (FAF) was done in feasible patients. Results: 9 out of 743(1.2%) patients were identified to have retinal toxicity, detected via fundus examination (n=9), SD-OCT (n=8/9), HVF 10-2 (n=6/9), FAF (n=1/9). 55.5% (n=5/9) had Rheumatoid Arthritis(RA) and 44.4% (n=4/9) had Systemic Lupus Erythematosus(SLE) as their primary diagnosis. 77.7% (n=7/9) were females. The mean age was 47.5 years (20-72 years).75%(n=3/4) of SLE patients were below 30 years of age. The average daily and cumulative dose of HCQ in these 9 patients were 244 mg (200-400mg) and 311.22g(73-730g)respectively, whereas the mean recommended dose as per real body weight was 287.2mg/day. Average duration of HCQ consumption was 3.6 years (1-10 years).Only 11.1% (n=1/9) had presented with visual complaints of black floaters. Conclusion: The asymptomatic nature of this irreversible toxicity, warrants frequent screening.Retinal toxicity was not age-related.Toxicity was manifested at low daily and cumulative doses.Screening should be done atleast every 6 months by fundus examination.Objective tests like HVF and SD-OCT should be done annually, especially in patients with underlying rheumatic diseases.The early manifestation of retinal toxicity in young SLE patients could have a genetic association and needs further evaluation. References: [1]Mortada A Abozaid et al. hydoxychloroquine retinopathy in a ohort of patients from upper Egypt.Journal of Egyptioan Ophthalmological Society 2017;110:110-113 [2]Roy AN,Samala V,Kumar YA,Fatima SS.Assessing the risk of retinopathy in Indian patients using hydroxychloroquine for rheumatic and musculoskeletal Diseases:A Retrospective Observational Study.Indian J Rheumatol 2020. Disclosure of Interests: None declared
Dupuytren’s disease
Authors: Marta Karbowiak, Thomas Holme, Kamran Khan, Arvind Mohan
Journal: BMJ (2021)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Dupuytren’s disease Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
AB0444 СLINICAL-IMMUNOLOGICAL CHARACTERISTICS OF PATIENTS WITH INFLAMMATORY MYOPATHIES
Authors: A. Khelkovskaia-Sergeeva, O. Desinova, M. Starovoytova, L. P. Ananyeva, M. Cherkasova, R. Shayakhmetova
Journal: Annals of the Rheumatic Diseases (2021)

Background: Inflammatory disorders of the skeletal muscle include polymyositis (PM), dermatomyositis (DM), amyopathic dermatomyositis ADM, (immune mediated) necrotizing myopathy (NM), overlap syndrome with myositis (overlap myositis, OM) and including anti-synthetase syndrome (ASS). The detection of myositis-specific antibodies, the clinical effect of which remains to be determined, may be of great importance for diagnosis. Objectives: To study clinical-immunological characteristics of patients with inflammatory myopathies. Methods: 57 pts were enrolled in this study: 28 (47%) pts were diagnosed with DM, 14 (23%) pts – OM, 5(8%) pts – PM, 5 (8%) pts-NM, 4 (7%) pts-ADM, 1 (2%)- ACC. Duration of disease in average 11,29 (2-48) month. Standard clinical examination and laboratory immunological evaluation including myositis-specific autoantibodies were performed. Results: There were 3 age groups: 18-39 years old – 16 (28%) pts, 40-49 yo – 28 (49%) pts and &gt; 60 yo – 13 (33%) pts. Symptoms of myositis were muscle weakness 57 (100%) pts, dysphagia 29 (51%) pts, arthritis -12 (21%) pts, Raynaud’s phenomenon 21 (37%) pts, skin lesions- 37 (65%) pts (Gottron signs- 7 (12%) pts, digital ulcers -11 (19) pts, panniculitis – 6(11%) pts, hand of mechanic 16(28%) pts). MMT 8 was 55,57 (SD 18,49) (20-80) score. Clinical features of myositis were myocarditis 8 (14%) pts and arrhythmia 9 (16%) pts, interstitial lung disease 20 (35%) pts, esophageal involvement 29 (51%) pts of them 5 (9%) pts needed enteral feeding. 2 (4%) pts had oncopathology. СК was increased in 49 (86%) pts: &lt; 10 N -15 (26%) pts, &gt;10 N – 28 (49%) pts, &gt; 50 N – 6 (11%). ANA positive - in 39 (70%) pts. Antibodies identified in 25(44%) pts: Pm-Scl 7 (12%) pts, PL-7 1 (2%), Mi-2 10 (17,5%), Ku 2 (3,5%) pts, AMA-M2 2 (2%)pts, a-SRP 4 (7%) and SS-A/Ro-52 13 (23%), SS-A/Ro-60 2 (3%) pts. Conclusion: The group of inflammatory myopathies is characterized by clinical and immunological heterogeneity. Finding antibodies specific for myositis can help diagnose the disease. Disclosure of Interests: None declared.
AB0468 IS THE USE OF INTERLEUKIN 17 INHIBITORS IN SPONDYLOARTHRITIS RELATED TO THE CLINICAL MANIFESTATIONS? 12-MONTH EXPERIENCE OF ONE RHEUMATOLOGY CENTER
Authors: M. Khapsirokova, Z. Kolkhidova, S. Erdes
Journal: Annals of the Rheumatic Diseases (2021)

Background: Therapy with interleukin 17 (iIL17) inhibitors in Russia is indicated for patients with ankylosing spondylitis (AS) or psoriatic arthritis (PSA). If standard therapy is ineffective in these diseases, both tumor necrosis factor inhibitors (iTNF) and iIL17 can be prescribed as the first biologics. Objectives: To study the clinical features of patients with spondyloarthritis (SPA) who were first prescribed iIL17 in a rheumatology center for 12 months. Methods: During the period from January to December 2019, iIL17 was initiated to 43 SPA patients. To compare the clinical picture, the study additionally included 40 SPA patients who were prescribed iTNF during the same period. The diagnosis of AS was based on the mNY criteria, and psoriatic arthritis was based on the CASPAR criteria. In the combined group of 83 patients, AS was in 52 (62.7%), and PSA – in 31; the age of patients was 39.3±10.8 years, and the duration of the disease was 15.1±8.2 years; men were 47 (56.6%). Results: In the iIL17 group, AS had 23 (53.5%) patients, and PSA – 20 (46.5%), while in the iTNF group, respectively, 29 (72.5%) and 11 (27.5%; χ2=3.2, p=0.76). Among the patients who were prescribed iIL17, men were 29 (67%), and in the iTNF group – 18 (45%; χ2=4.2, p=0.04). In terms of activity indicators (ESR, CRP, BASDAI ASDAS-CRP), patients who were prescribed iIL17 or iTNF did not differ significantly from each other. Peripheral arthritis, dactylitis, and entesitis were observed with almost the same frequency in both groups. In the iIL17 group, there were almost 2 times more patients with psoriasis (53.5% and 25.0%; p&lt;0.05) than in group iTNF and among them, significantly more frequent the patients had previous experience of iTNF treatment (41,9% and 17.5%; p&lt;0.05). Disease-modifying antirheumatic drugs often received patients in iTNF group (80.0% and 48.8%; p&lt;0.05). Conclusion: Thus, in clinical practice iIL17 often prescribed for SPA male patients with psoriasis and previous treatment experience by iTNF. The activity of the disease and the presence of non-axial manifestations practically do not affect the choice of biological therapy. Disclosure of Interests: None declared.
Effect of Sodium Nitrite on Survival of Cardiac Arrest to Hospital Admission—Reply
Authors: Francis Kim, Charles Maynard, Graham Nichol
Journal: JAMA (2021)

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