tbuckley/cabot-search huggingface dataset:
Long-term effects of percutaneous laser balloon ablation from the canine coronary sinus.
Authors: C DSchuger, LMcMath, GAbrams, HZhan, J RSpears, R TSteinman, M HLehmann
Journal: Circulation (1992)

BACKGROUNDRadiofrequency catheter ablation of left-sided accessory pathways is becoming the first line of therapy for patients with symptomatic Wolff-Parkinson-White syndrome. Nevertheless, alternative ablation techniques merit development, at least as supplementary modalities for cases in which conventional ablation approaches may prove unsuccessful. We recently reported the short-term results with transcatheter laser balloon ablation from the coronary sinus in a canine model, proving that the procedure is feasible for the potential ablation of left-sided accessory pathways. We now report the effects of percutaneous transcatheter laser balloon ablation in a chronic canine model.METHODS AND RESULTSTwenty adult mongrel dogs were studied. After baseline coronary arteriography, left ventriculography, and coronary sinus angiography were obtained, 15 dogs received two or three consecutive laser doses from the coronary sinus of 30-40 W for 15-30 seconds, for a total cumulative energy of 1,200-2,400 J. The five ...
Computed tomography for localization and sizing of experimental acute myocardial infarcts.
Authors: W RGray, L MBuja, H KHagler, R WParkey, J TWillerson
Journal: Circulation (1978)

Computed tomography (CT) has been used to quantitate acute myocardial infarct size in isolated, arrested canine hearts. Acute myocardial infarcts were produced in 20 hearts by either left anterior descending (13 dogs) or circumflex coronary artery ligation (seven dogs). Each animal was given iodinated contrast media intravenously immediately before sacrifice 24--72 hours postinfarction. All infarcts greater than 1 g and one of three infarcts 0.5 g or less were detected by CT imaging. Infarct volume determined by CT correlated with gross infarct weight (r=0.83). CT imaging, however, consistently underestimated infarct volume; underestimation was largest in a group of patchy, predominantly subendocardial infarcts. As adequate equipment and techniques for in vivo studies are developed, CT imaging of the heart may become important in clinical evaluation of myocardial infarction.
The effects of the rate of intravenous infusion of streptokinase and the duration of symptoms on the time interval to reperfusion in patients with acute myocardial infarction.
Authors: A SLew, PLaramee, BCercek, LRodriguez, P KShah, WGanz
Journal: Circulation (1985)

We studied the influence of the following variables on the time interval from initiation of an intravenous infusion of 750,000 U of streptokinase until reperfusion (reperfusion time) in 140 consecutive patients with an evolving acute myocardial infarction: (1) the rate of infusion of streptokinase, (2) the duration of chest pain before initiation of treatment, (3) patient age, (4) patient sex, (5) location of infarction, (6) history of previous myocardial infarction, and (7) pretreatment pathologic Q waves. The time of reperfusion was recognized by clinical criteria that were completely concordant with the anatomic findings in all 119 patients in whom patency or occlusion of the artery of infarction was established at delayed angiography (n = 116) or at postmortem examination (n = 3). The mean reperfusion time for the 129 patients for whom data were available was 49 +/- 36 min. The reperfusion time was inversely related to the rate of infusion of streptokinase (r = .41, p less than .001), but this effect ...
Effects of afterload reduction on global left ventricular and regional myocardial functions in the isolated canine heart with stenosis of a coronary arterial branch.
Authors: SIsoyama, YMaruyama, KAshikawa, SSato, HSuzuki, JWatanabe, YShimizu, EIno-Oka, TTakishima
Journal: Circulation (1983)

We examined the effects of graded reduction of afterload on the global left ventricular and regional myocardial functions as well as coronary hemodynamics in hearts with regional ischemia. We used isolated, paced canine hearts that were loaded with a hydraulic system that simulated the aortic input impedance of the dog's arterial tree. The loading conditions could be quantitatively and sequentially changed by the reduction of the systemic vascular resistance of the hydraulic system, while the preload was kept constant using a variable-height reservoir connected to the left atrium. The heart was perfused with arterial blood from a support dog. Mean coronary perfusion pressure was maintained equal to mean aortic pressure (AoP) by a servo-controlled pump. Then, the left circumflex branch was constricted to an approximate 50% flow reduction of the preischemic control condition. The myocardial lengths at ischemic and nonischemic regions were measured with two pairs of ultrasonic crystals. In the hearts without...
Variants in urate transporters, ADH1B, GCKR and MEPE genes associate with transition from asymptomatic hyperuricaemia to gout: results of the first gout versus asymptomatic hyperuricaemia GWAS in Caucasians using data from the UK Biobank
Authors: Gabriela Sandoval-Plata, Kevin Morgan, Abhishek Abhishek
Journal: Annals of the Rheumatic Diseases (2021)

To perform a genome-wide association study (GWAS) of gout cases versus asymptomatic hyperuricaemia (AH) controls, and gout cases versus normouricaemia controls, and to generate a polygenic risk score (PRS) to determine gout-case versus AH-control status.Gout cases and AH controls (serum urate (SU) ≥6.0 mg/dL) from the UK Biobank were divided into discovery (4934 cases, 56 948 controls) and replication (2115 cases, 24 406 controls) cohorts. GWAS was conducted and PRS generated using summary statistics in discovery cohort as the base dataset and the replication cohort as the target dataset. The predictive ability of the model was evaluated. GWAS were performed to identify variants associated with gout compared with normouricaemic controls using SU <6.0 mg/dL and <7.0 mg/dL thresholds, respectively.Thirteen independent single nucleotide polymorphisms (SNPs) in ABCG2, SLC2A9, SLC22A11, GCKR, MEPE, PPM1K-DT, LOC105377323 and ADH1B reached genome-wide significance and replicated as predictors of AH to gout transition. Twelve of 13 associations were novel for this transition, and rs1229984 (ADH1B) was identified as GWAS locus for gout for the first time. The best PRS model was generated from association data of 17 SNPs; and had predictive ability of 58.5% that increased to 69.2% on including demographic factors. Two novel SNPs rs760077(MTX1) and rs3800307(PRSS16) achieved GWAS significance for association with gout compared with normouricaemic controls using both SU thresholds.The association of urate transporters with gout supports the central role of hyperuricaemia in its pathogenesis. Larger GWAS are required to identify if variants in inflammatory pathways contribute to progression from AH to gout.
115P Survival data from EMPOWER-Lung 4: Phase II study of cemiplimab plus ipilimumab in the second-line (2L) treatment of advanced non-small cell lung cancer (NSCLC)
Authors: B.Y. Shim, S. Lee, J. de Castro Carpeño, C-H. Chiu, M. Cobo, H.R. Kim, J.S. Ryu, M. Majem Tarruella, Y. Summers, C.A. Thomas, Y. Xu, I. Lowy, P. Rietschel
Journal: Journal of Thoracic Oncology (2021)
Arterial and venous coronary pressure-flow relations in anesthetized dogs. Evidence for a vascular waterfall in epicardial coronary veins.
Authors: P NUhlig, R WBaer, G JVlahakes, F LHanley, L MMessina, J IHoffman
Journal: Circulation Research (1984)

The coronary circulation of anesthetized dogs was tested for the presence of vascular waterfalls by manipulating coronary arterial and coronary venous pressures. The left main coronary artery and the coronary sinus were cannulated, and relationships between coronary artery pressure, coronary sinus pressure, and coronary flow were studied. Experiments were conducted during diastolic arrests, under steady state conditions, in the absence of autoregulation. Relations of coronary flow to coronary sinus pressure at constant coronary artery pressure were consistent with the presence of a vascular waterfall in the coronary sinus. When the great cardiac vein was cannulated, relations of great vein flow to great vein pressure at constant coronary artery pressure were consistent with the presence of a vascular waterfall in the great vein, indicating that waterfall behavior can occur in epicardial veins other than the coronary sinus. In dogs on right heart bypass, with the coronary sinus and great vein uncannulated,...
Spatial heterogeneity of intracellular Ca2+ concentration in nonbeating guinea pig ventricular myocytes.
Authors: D JWilliford, V KSharma, MKorth, S SSheu
Journal: Circulation Research (1990)

The spatial distribution of intracellular Ca2+ concentration was determined by fluorescent digital imaging microscopy in fura-2-loaded quiescent cardiac myocytes isolated from guinea pig ventricle. Fluorescent ratio images revealed discrete as well as clustered bright fluorescent spots (hot spots), which occupied approximately 20-50% of an individual cell's area. The fluorescent intensity and the area of the hot spots were increased by agents that deplete Ca2+ in the sarcoplasmic reticulum, namely, ryanodine (20-40 nM) and caffeine (5-15 mM). However, when cells were exposed to agents that deplete mitochondrial Ca2+, such as the protonophore, carbonyl cyanide m-chlorophenyl-hydrazone (CCCP, 100-300 nM), or the inhibitor of electron transport, antimycin A (4-40 nM), the fluorescent intensity and the area of the hot spots were reduced. These results indicate that the spatial distribution of intracellular Ca2+ concentration in the ventricular myocytes of guinea pig is quite heterogeneous. The ability of CC...
Double Layer Stent for the Treatment of Leaks and Fistula After Upper Gastrointestinal Oncologic Surgery: A Retrospective Study
Authors: FV Mandarino, D Esposito, G Spelta, L Fanti, F Azzolini, E Viale, GM Cavestro, PA Testoni
Journal: Endoscopy (2021)

Aims Anastomotic dehiscence is one of the most morbidity related and deadly complication after foregut oncologic surgery. The use of self-expanding metal stents (SEMS) has been found effective for the treatment of esophageal post-surgical leaks or fistula. The aim of the study is to evaluate the effectiveness of double layer stents (Niti-S Beta Esophageal Stent) in the management of dehiscences after upper gastrointestinal oncologic surgery.
Case 26-2004
Authors: Thomas J. Lynch, Cameron D. Wright, Noah C. Choi, Suzanne L. Aquino, Eugene J. Mark
Journal: New England Journal of Medicine (2004)

A 56-year-old woman with a history of smoking began to have a cough that was productive of blood-tinged sputum. Radiography and computed tomographic scanning revealed a 2.5-cm nodule in the right upper lobe, with no mediastinal lymphadenopathy. Positron-emission tomographic scanning with fludeoxyglucose F 18 showed uptake in the nodule but not in the lymph nodes. A biopsy disclosed non–small-cell lung cancer. A multidisciplinary team discusses the approach to therapy.
Balloon dilation angioplasty of aortic coarctations in infants and children.
Authors: J ELock, J LBass, KAmplatz, B PFuhrman, WCastaneda-Zuniga
Journal: Circulation (1983)

Balloon dilation angioplasty (BDA) was attempted nine times in eight infants and children with aortic coarctation. In three infants (all with associated ventricular septal defect or atrioventricular canal and marked hemodynamic instability) dilation was attempted at a site of aortic narrowing that had not been operated on previously. Although the coarctation gradient fell 40% or more over the short term in two of the three, there was no angiographic or late gradient evidence of improvement. All three underwent subsequent coarctation surgery. Five dilations were performed in four infants and children who had previously undergone coarctation surgery (end-to-end anastomosis, attempted jump graft, and subclavian flap) and had residual gradients. Dilation was successful in all five cases, resulting in an increase in the diameter at the coarctation site (4.7 +/- 2.6 to 7.7 +/- 4.0 mm, p less than .05) and a decrease in the gradient measured 24 hr after dilation (42.0 +/- 15.5 to 11.8 +/- 11.2 mm Hg, p less than...
Heparin regulates smooth muscle S phase entry in the injured rat carotid artery.
Authors: M WMajesky, S MSchwartz, M MClowes, A WClowes
Journal: Circulation Research (1987)

Smooth muscle cell (SMC) proliferation in injured arteries is inhibited by heparin, but the mechanism of inhibition is unknown. In particular, it is not clear whether heparin prevents exit of quiescent SMC from the resting state, inhibits progression through the prereplicative (G1) sequence, or acts during DNA synthesis itself. In this study, induction of ornithine decarboxylase (ODC) activity was used as a marker of SMC entry into the cell cycle in an attempt to localize the site of heparin action during the initial hours after rat carotid injury. Rapid and transient induction of ODC activity was observed that reached a maximum (twenty-three-fold) 6 hours after wounding. Heparin failed to prevent ODC induction but greatly reduced frequencies of [3H]thymidine-labelled SMC nuclei 33 hours after injury. Moreover, heparin infusion could be delayed for up to 18 hours after the injury event with no significant loss of antiproliferative effect. Further delays resulted in marked loss of growth inhibition. The re...
Rickets in Asian immigrants.
Authors: N López Segura, M Bonet Alcaina, O García Algar
Journal: BMJ (1979)

With so much recent interest on dietary fibre, fibre-depleted starch foods have been said to be conducive to the development of diabetes in susceptible people with particular genotypes.22Certainly dietary fibre modifies carbohydrate absorption, and its favourable effect on diabetic control may be due to an effect on the incretin mechanism.
TCTAP C-078 Less is More: Hybrid Use of Drug-coated Balloon and Drug-eluting Stent in Non-left-main True Bifurcation PCI
Authors: Heng Shee Kim, Mahadevan Gurudevan, Vicknesan Kulasingham, Kim Fong Ng, Kumutha Gobal, Tee Choon Keong, Adelyn H, Chuey Yan Lee
Journal: Journal of the American College of Cardiology (2021)
Combined Screening: Blood Pressure and Cholesterol
Authors: N. Burgess Record
Journal: JAMA (1987)

<h3>To the Editor.—</h3> We believe, because of our favorable experience in rural Maine, that cholesterol screening and counseling can be added successfully to an ongoing hypertension program, and this is relevant to the impending nationwide cholesterol education campaign.<sup>1</sup> The Franklin Blood Pressure Program has conducted hypertension screening, follow-up, referral, and education since 1974.<sup>2</sup>With medical staff endorsement and state subsidy for a pilot project, we added cholesterol in November 1986, performing on-site finger-prick measurements. To ensure continued focus on hypertension, we decided always to check blood pressure whenever we measured cholesterol level. During the five-month period ending March 1987, cholesterol level and blood pressure together were measured for 1388 individuals at 12 community clinics and 24 work sites. Cholesterol/blood pressure screenees were 42% male overall and 50% male in the 20- to 40-year age group. Our cholesterol level screening results were consistent with national age-specific criteria: 48% at
Paraneoplastic Limbic Encephalitis Secondary to SCLC on 18F-FDG PET/CT
Authors: Alinne Fernanda Amaral Verçosa, Isabella Araújo Mota, Maria Eduarda Duarte de Mello Flamini, Rodrigo de Carvalho Flamini
Journal: Clinical Nuclear Medicine (2021)

Abstract A 67-year-old man with rapidly neurologic deterioration and 15 kg weight loss in 2 months was extensively evaluated by several medical specialties and conventional image examinations, with no diagnostic definition. 18 F-FDG PET/CT was performed, showing glycolytic hypermetabolism in the hippocampus, cerebral hypometabolism with posterior temporoparietal pattern, multiple cervical and supraclavicular lymph nodes, and mediastinal hypermetabolic and enlarged lymph nodes, suggesting paraneoplastic limbic encephalitis, Alzheimer dementia, and lymphoma. Lymph node biopsy resulted in small cell lung carcinoma. The patient presented rapid clinical deterioration and died.
From the authors:
Authors: R. Wensel
Journal: European Respiratory Journal (2010)

In their letter about our report on autonomic nervous system disturbances in severe pulmonary hypertension 1 and its companion editorial 2, B. Raffestin and M. Leroy are right that we only measured baroreceptor heart rate control. However, the criticism that we measured this with the wrong method is incorrect. The sequence and a-index method is widely accepted in the cardiology community and the administration of vasoconstrictors (phenylephrine method) considered obsolete, and …
RELAPSE AFTER AUTOGRAFTING WITH PERIPHERAL BLOOD STEM CELLS
Authors: J.P. Laporte, N.C. Gorin, J. Feuchtenbaum, M. Lopez, L. Douay, D. Lyon-Caen, M.C. du Puy Montbrun, M.P. Lemonnier, F. Isnard, A. Najman
Journal: The Lancet (1987)
162P Long-term efficacy and genomic characteristics of patients with TRK fusion lung cancer treated with larotrectinib
Authors: V. Moreno Garcia, J. Lin, J. Patel, U. Lassen, B. Solomon, L. Rosen, S. Leyvraz, D.S.W. Tan, J.A. Reeves, G. Beckmann, M. Rudolph, J. Wierzbinska, L. Dima, N. Brega, S. Kummar, A. Drilon
Journal: Journal of Thoracic Oncology (2021)
Frequency of First Generic Drug Approvals With “Skinny Labels” in the United States
Authors: Bryan S. Walsh, Ameet Sarpatwari, Benjamin N. Rome, Aaron S. Kesselheim
Journal: JAMA Internal Medicine (2021)

sidered quality of life and comorbidities.Although those with advanced dementia were less likely to have had an emergency department visit for hypoglycemia, a potentially critical moment for intervention, this may reflect their relative inability to express the symptoms of dizziness, headaches, or other hypoglycemia-related outcomes.Moreover, delirium and metabolic encephalopathies facilitated by recurrent hypoglycemia, electrolyte derangements, and subtle brain hypoperfusion are difficult to track accurately over time.It is not known whether repeated dips in blood glucose levels may worsen dementia, although prior work has found that tight glycemic control does not seem to improve cognitive function. 4reater attention is needed to prevent diabetes-related treatment complications.Dementia is increasingly common among aging patients with diabetes and other vascular risk factors, and clinicians should more actively deprescribe sulfonylureas in patients older than 70 years.Regular reevaluations that consider changes in comorbidity burden, cognitive function, quality of life, and treatment goals should aim to reduce polypharmacy and liberalize glycemic treatment targets among patients with advanced cognitive impairment.As patients age, the benefits of treatment should be questioned, and the increasing risks recognized, especially for older, cognitively impaired patients with diabetes and limited life expectancy.
The calcium channel blocker nitrendipine blocks sodium channels in neonatal rat cardiac myocytes.
Authors: AYatani, A MBrown
Journal: Circulation Research (1985)

The dihydropyridine calcium channel blocker, nitrendipine, was studied for its effects on the sodium current of single cultured ventricular cells from neonatal rats. The patch-clamp method of recording whole cell currents was used, and sodium currents were isolated by suppressing potassium and calcium currents. Potassium currents were blocked by replacing potassium with cesium in the internal and external solutions and by adding tetraethylammonium chloride and 4-aminopyridine in the external solution; calcium current was blocked by replacing calcium with cobalt in the external solution. At low frequencies (0.1 Hz), nitrendipine reduced sodium currents without any significant change in the current-voltage relation. The block was dose dependent, and assuming a single occupancy model with complete block, had a half-maximum value of 3 X 10(-6) M at a holding potential of -80 mV where half the sodium channels are activatable. This value is within the range of the Kd's that have been reported for low-affinity d...
Calcium sensitivity of isometric force in intact and chemically skinned aortas during the development of aldosterone-salt hypertension in the rat.
Authors: E GMcMahon, R JPaul
Journal: Circulation Research (1985)

We investigated the role of altered vascular calcium handling in the development of aldosterone-salt hypertension in the rat. The calcium sensitivity of isometric force in response to 50 mM KCl was compared in aortic rings from control and aldosterone-hypertensive rats. Over the entire range of calcium concentrations studied, responses in aortas from the hypertensives were significantly depressed compared to controls [ED50: aldosterone-hypertensive rats (n = 6), 0.739 +/- 0.137; controls (n = 7), 0.141 +/- 0.021 mM; P less than 0.001]. However, calcium sensitivity in response to 1 microM norepinephrine was similar in aortas from both hypertensives and controls [ED50: aldosterone-hypertensive rats (n = 7), 0.196 +/- 0.022; controls (n = 7), 0.180 +/- 0.024 mM]. The calcium sensitivity of Triton X-100 skinned aortic rings from aldosterone-hypertensive rats was likewise not significantly different from sensitivity in controls [ED50: aldosterone-hypertensive rats (n = 9), 3.61 X 10(-7) +/- 0.57; controls (n =...
Comparison of Histological Quality Between 22-Gauge Fine Needle Aspiration and Fine Needle Biopsy of Solid Pancreatic Lesions
Authors: T Lambin, O Karleskind, E Leteurtre, A Bongiovanni, M Tardivel, F Renaud, J Branche, R Gérard
Journal: Endoscopy (2021)

Aims Regarding pancreatic lesions, most studies comparing EUS-FNA (endoscopic ultrasound guided fine needle aspiration) and EUS-FNB (fine needle biopsy) have shown no difference in term of diagnostic accuracy. Few studies have assessed the quality of histological samples obtained with each needles. The aim of the present study was to compare the histological quality of samples obtained with EUS-FNA and EUS-FNB for pancreatic solid lesion.
Comparison of multiple views for the evaluation of pulmonary arterial blood flow by Doppler echocardiography.
Authors: G WLighty, AGargiulo, IKronzon, FPolitzer
Journal: Circulation (1986)

Forty adult patients underwent Doppler and two-dimensional echocardiographic examination of the pulmonary artery from multiple views to determine the variability in the magnitude of Doppler-determined flow velocity and pulmonary arterial diameter from various echocardiographic windows. Flows were recorded from two or more views in 32 patients (80%). Twelve of these patients (38%) had flow velocities recorded from two or more views that were within 6% of each other. Twenty of these patients (62%) had view-dependent differences in measured flow velocity ranging from 7% to 48%. The commonly used parasternal short-axis view yielded the highest pulmonary arterial flow velocity in only 35% of the patients studied. Determinations of pulmonary arterial blood flow can vary markedly when measured from different sites, and this is presumably due to varying ability to approximate a zero-degree Doppler angle from different views. Measurement of pulmonary arterial flow velocity should be attempted from multiple views, ...