Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19
Authors: Pere Domingo, Isabel Mur, Gracia María Mateo, Maria del Mar Gutierrez, Virginia Pomar, Natividad de Benito, Noemí Corbacho, Silvia Herrera, Lucia Millan, Jessica Muñoz, Jorge Malouf, Maria Ema Molas, Victor Asensi, Juan Pablo Horcajada, Vicente Estrada, Felix Gutierrez, Ferran Torres, Jose A Perez-Molina, Jesús Fortun, Luisa M Villar, Ulla Hohenthal, Harri Marttila, Tytti Vuorinen, Marika Nordberg, Mika Valtonen, Matthew J Frigault, Michael K Mansour, Naomi J Patel, Ana Fernandes, Liam Harvey, Andrea S Foulkes, Brian C Healy, Ruta Shah, Ana Maria Bensaci, Ann E. Woolley, Sarah Nikiforow, Nina Lin, Manish Sagar, Harry Shrager, David S. Huckins, Matthew Axelrod, Michael D Pincus, Jorge Fleisher, Jon Lampa, Piotr Nowak, Jan C. Vesterbacka, Johan Rasmuson, Paul Skorup, Helena Janols, Katarina F Niward, Katerina Chatzidionysiou, Hilmir Asgeirsson, Åsa Parke, Ola Blennow, Anna-Karin Svensson, Soo  Aleman, Anders Sönnerborg, Jan-Inge Henter, Anna Carin Horne, Farah Al-Beidh, Derek Angus, Djillali Annane, Yaseen Arabi, Abigail Beane, Scott Berry, Zahra Bhimani, Marc Bonten, Charlotte Bradbury, Frank Brunkhorst, Meredith Buxton, Allen Cheng, Matt Cove, Menno De Jong, Lennie Derde, Lise Estcourt, Herman Goossens, Anthony Gordon, Cameron Green, Rashan Haniffa, Nao Ichihara, Francois Lamontagne, Patrick Lawler, Ed Litton, John Marshall, Colin McArthur, Daniel McAuley, Shay McGuinness, Bryan McVerry, Stephanie Montgommery, Paul Mouncey, Srinivas Murthy, Alistair Nichol, Rachael Parke, Jane Parker, Felipe Reyes, Kathryn Rowan, Hiroki Saito, Marlene Santos, Chris Seymour, Manu Shankar-Hari, Alexis Turgeon, Anne Turner, Wilma van Bentum-Puijk, Frank van de Veerdonk, Steve Webb, Ryan Zarychanski, J Kenneth Baillie, Richard Beasley, Nichola Cooper, Robert Fowler, James Galea, Thomas Hills, Andrew King, Susan Morpeth, Mihai Netea, Kayode Ogungbenro, Ville Pettila, Steve Tong, Tim Uyeki, Taryn Youngstein, Alisa Higgins, Elizabeth Lorenzi, Lindsay Berry, Carlos Salama, Ivan O. Rosas, Belén Ruiz-Antorán, Elena Muñez Rubio, Antonio Ramos Martínez, José Campos Esteban, Cristina Avendaño Solá, Reuven Pizov, Jesus Sanz Sanz, Francisco Abad-Santos, Azucena Bautista-Hernández, Lucio García-Fraile, Ana Barrios, Ángela Gutiérrez Liarte, Tamara Alonso Pérez, Sebastian C Rodríguez-García, Gina Mejía-Abril, Jose Carlos Prieto, Rafael Leon, VIVIANE C. VEIGA, PHILLIP SCHEINBERG, DANIELLE L.C. FARIAS, JOÃO G. PRATS, ALEXANDRE B. CAVALCANTI, FLAVIA R. MACHADO, REGIS G. ROSA, OTÁVIO BERWANGER, LUCIANO C.P. AZEVEDO, RENATO D. LOPES, LETICIA K. DOURADO, CLAUDIO G. CASTRO, FERNANDO G. ZAMPIERI, ALVARO AVEZUM, THIAGO C. LISBOA, SALOMÓN S.O. ROJAS, JULIANA C. COELHO, RODRIGO T. LEITE, JULIO CESAR CARVALHO, LUIS E.C. ANDRADE, ALEX R. SANDES, MARIA CAROLINA T. PINTÃO, SUELI V. SANTOS, THIAGO M.L. ALMEIDA, ANDRÉ N. COSTA, OTAVIO  C.E. GEBARA, FLAVIO G.R. FREITAS, EDUARDO S. PACHECO, DAVID J.B. MACHADO, JOSIANE MARTIN, FABIO G. CONCEIÇÃO, SUELLEN R.R. SIQUEIRA, LUCAS P. DAMIANI, LUCIANA M. ISHIHARA, DANIEL SCHNEIDER, DENISE DE SOUZA, Olivier Hermine, Xavier Mariette, Pierre Louis Tharaux, Matthieu Resche Rigon, Raphael Porcher, Philippe Ravaud, Elie Azoulay, Jacques Cadranel, Joseph Emmerich, Muriel Fartoukh, Bertrand Guidet, Marc Humbert, Karine Lacombe, Matthieu Mahevas, Frédéric Pene, Valérie Pourchet-Martinez, Frédéric Schlemmer, Annick Tibi, Yazdan Yazdanpanah, Maxime Dougados, Serge Bureau, Peter W Horby, Martin J Landray, Kenneth J Baillie, Maya H Buch, Lucy C Chappell, Jeremy N Day, Saul N Faust, Richard Haynes, Thomas Jaki, Katie Jeffery, Edmund Juszczak, Wei Shen Lim, Marion Mafham, Alan Montgomery, Andrew Mumford, Guy Thwaites, Adeeba Kamarulzaman, Sharifah Faridah Syed Omar, Sasheela Ponnampalavanar, Raja Iskandar Syah Raja Azwa, Pui Li Wong, Anjanna Kukreja, Hang Cheng Ong, Helmi Sulaiman, Sazali Basri, Rong Xiang Ng, Bushra Megat Johari, Reena Rajasuriar, Meng Li Chong, Malinee Neelamegam, Syed Mukhtar Syed Mansor, Nurul Syuhada Zulhaimi, Cheng Siang Lee, Frederick Altice, Christina Price, Maricar Malinis, Mohd Shahnaz Hasan, Chee Kuan Wong, Suresh Chidambaram, Nor Arisah Misnan, Alif Adlan Mohd Thabit, Benedict Sim, Farah Nadiah Bidin, Mohd Abd Hafiz Mohd Abd Rahim, Sujana Saravanamuttu, Wei Xuan Tuang, Yasmin Mohamed Gani, Suvintheran Thangavelu, Kim Heng Tay, Nur Munirah Ibrahim, Luqman Alhakim Halid, Kok Tong Tan, Mohd Noor Azreet Mukri, Masita Arip, Hui Moon Koh, Syarifah Nurul Ain Syed Badaruddin, Letchumi Raja Sureja, Geok Ying Chun, JULIAN TORRE-CISNEROS, NICOLAS MERCHANTE, RAFAEL LEON, SHEILA CARCEL, JOSE CARLOS GARRIDO, Eitan Galun, Alex Soriano, José Antonio Martínez, Clara Castán, Roger Paredes, David Dalmau, Cristina Carbonell, Gerard Espinosa, Pedro Castro, José Muñóz, Alex Almuedo, Sergio Prieto, Iván Pacheco, Mark Ratain, Jennifer Pisano, Mary Strek, Ayodeji Adegunsoye, Theodore Karrison, Declercq Jozefien, Van Damme Karel F.A., De Leeuw Elisabeth, Bosteels Cedric, Maes Bastiaan, Manu Shankar-Hari, Claire L. Vale, Peter J. Godolphin, David Fisher, Julian P. T. Higgins, Francesca Spiga, Jelena Savovic, Jayne Tierney, Gabriel Baron, Julie S. Benbenishty, Lindsay R. Berry, Niklas Broman, Alexandre Biasi Cavalcanti, Roos Colman, Stefanie L. De Buyser, Lennie P. G. Derde, Pere Domingo, Sharifah Faridah Omar, Ana Fernandez-Cruz, Thijs Feuth, Felipe Garcia, Rosario Garcia-Vicuna, Isidoro Gonzalez-Alvaro, Anthony C. Gordon, Richard Haynes, Olivier Hermine, Peter W. Horby, Nora K. Horick, Kuldeep Kumar, Bart N. Lambrecht, Martin J. Landray, Lorna Leal, David J. Lederer, Elizabeth Lorenzi, Xavier Mariette, Nicolas Merchante, Nor Arisah Misnan, Shalini V. Mohan, Michael C. Nivens, Jarmo Oksi, Jose A. Perez-Molina, Reuven Pizov, Raphael Porcher, Simone Postma, Reena Rajasuriar, Athimalaipet V. Ramanan, Philippe Ravaud, Pankti D. Reid, Abraham Rutgers, Aranzazu Sancho-Lopez, Todd B. Seto, Sumathi Sivapalasingam, Arvinder Singh Soin, Natalie Staplin, John H. Stone, Garth W. Strohbehn, Jonas Sunden-Cullberg, Julian Torre-Cisneros, Larry W. Tsai, Hubert van Hoogstraten, Tom van Meerten, Viviane Cordeiro Veiga, Peter E. Westerweel, Srinivas Murthy, Janet V. Diaz, John C. Marshall, Jonathan A. C. Sterne
Journal: JAMA (2021)

Clinical trials assessing the efficacy of IL-6 antagonists in patients hospitalized for COVID-19 have variously reported benefit, no effect, and harm.