tbuckley/cabot-search huggingface dataset:
Hospitalization for self-harm during the early months of the COVID-19 pandemic in France: A nationwide retrospective observational cohort study
Authors: Fabrice JOLLANT, Adrien ROUSSOT, Emmanuelle CORRUBLE, Jean-Christophe CHAUVET-GELINIER, Bruno FALISSARD, Yann MIKAELOFF, Catherine QUANTIN
Journal: The Lancet Regional Health - Europe (2021)

Little is known to date about the impact of COVID-19 pandemic on self-harm.The number of hospitalizations for self-harm (ICD-10 codes X60-X84) in France from 1st January to 31st August 2020 (including a two-month confinement) was compared to the same periods in 2017-2019. Statistical methods comprised Poisson regression, Cox regression and Student's t-test, plus Spearman's correlation test relating to spatial analysis of hospitalizations.There were 53,583 self-harm hospitalizations in France during January to August 2020. Compared to the same period in 2019, this represents an overall 8·5% decrease (Relative Risk [95% Confidence Interval] = 0·91 [0·90-0·93]).This decrease started in the first week of confinement and persisted until the end of August. Similarly, decrease was found in both women (RR=0·90 [0·88-0·92]) and men (RR=0·94 [0·91-0·95]), and in all age groups, except 65 years and older. Regarding self-harm hospitalizations by means category, increases were found for firearm (RR=1·20 [1·03-1·40]) and for jumping from heights (RR=1·10 [1·01-1·21]). There was a trend for more hospitalizations in intensive care (RR=1·03 [0·99-1·07]). The number of deaths at discharge from hospital also increased (Hazard Ratio = 1·19 [1·09-1·31]). Self-harm hospitalizations were weakly correlated with the rates of hospitalization for COVID-19 across administrative departments (Spearman's rho =-0·21; p = 0·03), but not with overall hospitalizations.The COVID-19 pandemic had varied effects on self-harm hospitalizations during the early months in France. Active suicide prevention strategies should be maintained.French National Research Agency.
EFFECTS OF CHRONIC KIDNEY DISEASE AND DECLINING RENAL FUNCTION ON CORONARY ATHEROSCLEROTIC PLAQUE PROGRESSION: A PARADIGM SUBSTUDY
Authors: Alex Lin-I Huang, Jonathon Leipsic, Martin Hadamitzky, Yong-Jin Kim, Edoardo Conte, Daniele Andreini, Gianluca Pontone, Matthew Budoff, Ilan Gottlieb, Byoung Kwon Lee, Eun Ju Chun, Filippo Cademartiri, Erica Maffei, Hugo Marques, Sanghoon Shin, Jung Hyun Choi, Renu Virmani, Habib Samady, Peter H. Stone, Daniel Berman, Jagat Narula, Leslee Shaw, Jeroen Bax, Hyuk-Jae Chang
Journal: Journal of the American College of Cardiology (2021)
Domains and outcomes of the core outcome set of congenital melanocytic naevi for clinical practice and research (the OCOMEN project): part 2*
Authors: A.C. Fledderus, S.G.M.A. Pasmans, A. Wolkerstorfer, W. Oei, H.C. Etchevers, M.S. Kessel, C.M.A.M. Horst, P.I. Spuls
Journal: British Journal of Dermatology (2021)

Congenital melanocytic naevi (CMN) can have a great impact on patients' lives owing to perceived stigmatization, and the risk of melanoma development and neurological complications. Development of a core outcome set (COS) for care and research in CMN will allow standard reporting of outcomes. This will enable comparison of outcomes, allowing professionals to offer advice about the best management options. In previous research, stakeholders (patients, parents and professionals) reached consensus on the core domains of the COS. To select the appropriate measurement instruments, the domains should be specified by outcomes.To reach consensus on the specific core outcomes describing the core domains pertaining to clinical care and research in CMN.A list of provisional outcomes (obtained earlier) was critically reviewed by the Outcomes for COngenital MElanocytic Naevi (OCOMEN) research team and by relevant stakeholders through an online questionnaire, to refine this list and provide clear definitions for every outcome. When needed, discussion with individual participants was undertaken over the telephone or by email. During an online consensus meeting, stakeholders discussed the inclusion of potential outcomes. After the meeting, participants voted in two rounds for the inclusion of outcomes.Forty-four stakeholders from 19 countries participated. Nine core outcomes were included in the COS relative to clinical care and 10 core outcomes for research.These core outcomes will enable standard reporting in future care and research of CMN. This study facilitates the next step of COS development: selecting the appropriate measurement instruments for every outcome.
LVOT OBSTRUCTION IN HYPERTROPHIC CARDIOMYOPATHY: DEEMPHASIZING VENTURI EFFECT AND FOCUSING ON LV FLOW VORTEX AND MITRAL LEAFLET EXCESS
Authors: Abhas Khurana, Adee Elhamdani, Kirtivardhan Vashistha, Jian Hu, Robert Biederman, Victor Farah, Pietro Bajona, Craig Alpert, Srinivas Murali, Jennifer Keeley, Vinh Nguyen
Journal: Journal of the American College of Cardiology (2021)
Genetic Characterization and Clinical Impact of Loss of MHC Class I and II Expression in De Novo Diffuse Large B-Cell Lymphoma
Authors: Daisuke Ennishi, Anja Mottok, Pedro Farinha, Fong Chun Chan, Ali Bashashati, Saeed Saberi, Barbara Meissner, Merrill Boyle, Susana Ben-Neriah, Robert Kridel, Kerry J Savage, Laurie H. Sehn, Ryan D. Morin, Marco A Marra, Sohrab P Shah, Joseph M Connors, Randy D. Gascoyne, David W. Scott, Christian Steidl
Journal: Blood (2017)
Intelligent phototriggered nanoparticles induce a domino effect for multimodal tumor therapy
Authors: Xiao Xu, Chao Han, Can Zhang, Dan Yan, Chunling Ren, Lingyi Kong
Journal: Theranostics (2021)

: Integration of several monotherapies into a single nanosystem can produce remarkable synergistic antitumor effects compared with separate delivery of combination therapies. We developed near-infrared (NIR) light-triggered nanoparticles that induce a domino effect for multimodal tumor therapy.
Intrauterine exposure to immunosuppressants influences the development of postnatal allergic diseases
Authors: Chie Kohno, Kayoko Kaneko, Kunihiko Takahashi, Yukihiro Ohya, Hiroshi Nakajima, Atsuko Murashima
Journal: Allergy (2021)

Dr. Ohya reports grants and personal fees from Maruho, grants from Yakurt, personal fees from Abbvie, Bayer, Chugai, Eli Lilly Japan, Torii Pharma, Towa Pharma, Mylan, Sanofi, outside the submitted work. Dr. Nakajima reports grants and personal fees from Chugai Pharmaceutical, grants and personal fees from Abbvie, grants and personal fees from Takeda Pharmaceutical, grants and personal fees from AstellasPharma, grants and personal fees from Eli Lilly Japan, grants and personal fees from Asahi kaseiPharma, grants and personal fees from Pfizer Japan, grants from UCB Japan, grants and personal fees from Eizai, grants and personal fees from Mitsubishi Tanabe Pharma, grants and personal fees from Bristle Myers Squibb, personal fees from Nihon Kayaku, outside the submitted work. Dr. Murashima reports lecture fees from AstellasPharma outside the submitted work. The other authors have declared no conflicts of interest. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Computational Methods to Measure Patterns of Gaze in Toddlers With Autism Spectrum Disorder
Authors: Zhuoqing Chang, J. Matias Di Martino, Rachel Aiello, Jeffrey Baker, Kimberly Carpenter, Scott Compton, Naomi Davis, Brian Eichner, Steven Espinosa, Jacqueline Flowers, Lauren Franz, Adrianne Harris, Jill Howard, Sam Perochon, Eliana M. Perrin, Pradeep Raj Krishnappa Babu, Marina Spanos, Connor Sullivan, Barbara K. Walter, Scott H. Kollins, Geraldine Dawson, Guillermo Sapiro
Journal: JAMA Pediatrics (2021)

<h3>Importance</h3> Atypical eye gaze is an early-emerging symptom of autism spectrum disorder (ASD) and holds promise for autism screening. Current eye-tracking methods are expensive and require special equipment and calibration. There is a need for scalable, feasible methods for measuring eye gaze. <h3>Objective</h3> Using computational methods based on computer vision analysis, we evaluated whether an app deployed on an iPhone or iPad that displayed strategically designed brief movies could elicit and quantify differences in eye-gaze patterns of toddlers with ASD vs typical development. <h3>Design, Setting, and Participants</h3> A prospective study in pediatric primary care clinics was conducted from December 2018 to March 2020, comparing toddlers with and without ASD. Caregivers of 1564 toddlers were invited to participate during a well-child visit. A total of 993 toddlers (63%) completed study measures. Enrollment criteria were aged 16 to 38 months, healthy, English- or Spanish-speaking caregiver, and toddler able to sit and view the app. Participants were screened with the Modified Checklist for Autism in Toddlers–Revised With Follow-up during routine care. Children were referred by their pediatrician for diagnostic evaluation based on results of the checklist or if the caregiver or pediatrician was concerned. Forty toddlers subsequently were diagnosed with ASD. <h3>Exposures</h3> A mobile app displayed on a smartphone or tablet. <h3>Main Outcomes and Measures</h3> Computer vision analysis quantified eye-gaze patterns elicited by the app, which were compared between toddlers with ASD vs typical development. <h3>Results</h3> Mean age of the sample was 21.1 months (range, 17.1-36.9 months), and 50.6% were boys, 59.8% White individuals, 16.5% Black individuals, 23.7% other race, and 16.9% Hispanic/Latino individuals. Distinctive eye-gaze patterns were detected in toddlers with ASD, characterized by reduced gaze to social stimuli and to salient social moments during the movies, and previously unknown deficits in coordination of gaze with speech sounds. The area under the receiver operating characteristic curve discriminating ASD vs non-ASD using multiple gaze features was 0.90 (95% CI, 0.82-0.97). <h3>Conclusions and Relevance</h3> The app reliably measured both known and new gaze biomarkers that distinguished toddlers with ASD vs typical development. These novel results may have potential for developing scalable autism screening tools, exportable to natural settings, and enabling data sets amenable to machine learning.
Association of Preeclampsia With Incident Stroke in Later Life Among Women in the Framingham Heart Study
Authors: Adam de Havenon, Alen Delic, Eric Stulberg, Nazanin Sheibani, Greg Stoddard, Heidi Hanson, Lauren Theilen
Journal: JAMA Network Open (2021)

<h3>Importance</h3> Contemporary research suggests an association between preeclampsia and later-life stroke among women. To our knowledge, no research to date has accounted for the time-varying nature of shared risk factors for preeclampsia and later-life stroke incidence. <h3>Objective</h3> To assess the relative risk of incident stroke in later life among women with and without a history of preeclampsia after accounting for time-varying covariates. <h3>Design, Setting, and Participants</h3> This population-based cohort study was a secondary analysis of data from the Framingham Heart Study, which was conducted from 1948 to 2016. Women were included in the analysis if they were stroke free at enrollment and had a minimum of 3 study visits and 1 pregnancy before menopause, hysterectomy, or age 45 years. Data on vascular risk factors, history of preeclampsia, and stroke incidence were collected biannually. Participants were followed up until incident stroke or censorship from the study. Marginal structural models were used to evaluate the relative risk of incident stroke among participants with and without a history of preeclampsia after accounting for time-varying covariates. Data were analyzed from May 2019 to December 2020. <h3>Exposures</h3> Presence or absence of preeclampsia among women with 1 or more pregnancies. <h3>Main Outcomes and Measures</h3> Incident stroke in later life. <h3>Results</h3> A total of 1435 women (mean [SD] age, 44.4 [7.7] years at the beginning of the study; 100% White) with 41 422 person-years of follow-up were included in the analytic sample. Of those, 169 women had a history of preeclampsia, and 231 women experienced strokes during follow-up. At baseline, women with preeclampsia were more likely to be younger, to be receiving cholesterol-lowering medications, to have lower cholesterol and higher diastolic blood pressure, and to currently smoke. The association between preeclampsia and stroke in the marginal structural model was only evident when adjustment was made for all vascular risk factors over the life course, which indicated that women with a history of preeclampsia had a higher risk of stroke in later life compared with women without a history of preeclampsia (relative risk, 3.79; 95% CI, 1.24-11.60). <h3>Conclusions and Relevance</h3> The findings of this cohort study suggest that preeclampsia may be a risk factor for later-life stroke among women after adjustment for time-varying vascular and demographic factors. Future research is warranted to fully explore the mediation of this association by midlife vascular risk factors.
STRUCTURAL VALVE DETERIORATION OF TRANSCATHETER VERSUS SURGICAL AORTIC VALVES IN PATIENTS WITH CHRONIC KIDNEY DISEASE: INSIGHTS FROM THE PARTNER 2A TRIAL AND SAPIEN 3 INTERMEDIATE RISK REGISTRY
Authors: Santiago Garcia, Roberto Cubeddu, Rebecca Hahn, Julien Ternacle, Samir Kapadia, Susheel Kodali, Vinod Thourani, Wael Jaber, Craig Asher, Sammy Elmariah, Raj Makkar, John Webb, Howard Herrmann, Michael Lu, Chandan Devireddy, S. Chris Malaisrie, Craig Smith, Michael Mack, Joao Cavalcante, Martin Leon, Philippe Pibarot
Journal: Journal of the American College of Cardiology (2021)
Transcatheter Occlusion of a Hepatic Vein to left Atrium Fistula: Should we close Venovenous collateral Vessels following Fontan operation?
Authors: Fadi Bitar, Maya El-Khouri, Mariam Arabi, Issam El Rassi, Ziad Bulbul, Fadi Sawaya
Journal: Clinical Cardiology and Cardiovascular Interventions (2021)

following the Fontan operation. There are conflicting data regarding the closure of the venovenous collateral (VVC) vessels post-Fontan. The embolization of these VVC in older patients may be associated with decreased survival. We describe a rare fistula draining a right-sided hepatic vein connected to a hepatic venous plexus to a right-sided pulmonary venous atrium in a child with visceral heterotaxy. The patient presented with severe hypoxemia following the Fontan operation. The fistula was successfully occluded by an AMPLATZER™ Vascular Plug II to resolve the hypoxemia and improve the hemodynamic status. Approach to venovenous collaterals in older patients with mild cyanosis after the Fontan operation may differ from that in younger children with severe hypoxemia and intrahepatic VVC. Patients with profound cyanosis due to intrahepatic to atrial connection may benefit from the occlusion of these connections. Percutaneous closure of hepatic to atrial connection with significant hypoxemia following appropriate hemodynamic assessment may be beneficial.
Chromosome 1q21 abnormalities in multiple myeloma
Authors: Timothy M. Schmidt, Rafael Fonseca, Saad Z. Usmani
Journal: Blood Cancer Journal (2021)

Abstract Gain of chromosome 1q (+1q) is one of the most common recurrent cytogenetic abnormalities in multiple myeloma (MM), occurring in approximately 40% of newly diagnosed cases. Although it is often considered a poor prognostic marker in MM, +1q has not been uniformly adopted as a high-risk cytogenetic abnormality in guidelines. Controversy exists regarding the importance of copy number, as well as whether +1q is itself a driver of poor outcomes or merely a common passenger genetic abnormality in biologically unstable disease. Although the identification of a clear pathogenic mechanism from +1q remains elusive, many genes at the 1q21 locus have been proposed to cause early progression and resistance to anti-myeloma therapy. The plethora of potential drivers suggests that +1q is not only a causative factor or poor outcomes in MM but may be targetable and/or predictive of response to novel therapies. This review will summarize our current understanding of the pathogenesis of +1q in plasma cell neoplasms, the impact of 1q copy number, identify potential genetic drivers of poor outcomes within this subset, and attempt to clarify its clinical significance and implications for the management of patients with multiple myeloma.
UPLC‐MS/MS‐based plasma lipidomics reveal a distinctive signature in systemic lupus erythematosus patients
Authors: Jiaxi Chen, Chong Liu, Shenyi Ye, Ruyue Lu, Hongguo Zhu, Jiaqin Xu
Journal: MedComm (2021)

Abstract Global lipidomics is of considerable utility for exploring altered lipid profiles and unique diagnostic biomarkers in diseases. We aim to apply ultra‐performance liquid chromatography‐tandem mass spectrometry to characterize the lipidomics profile in systemic lupus erythematosus (SLE) patients and explore the underlying pathogenic pathways using the lipidomics approach. Plasma samples from 18 SLE patients, 20 rheumatoid arthritis (RA) patients, and 20 healthy controls (HC) were collected. A total of 467 lipids molecular features were annotated from each sample. Orthogonal partial least square‐discriminant analysis, K‐mean clustering analysis and Kyoto Encyclopedia of Genes and Genomes pathway analysis indicated disrupted lipid metabolism in SLE patients, especially in phospholipid, glycerol, and sphingolipid metabolism. The area under curve (AUC) of lipid metabolism biomarkers was better than SLE inflammation markers that ordinarily used in the clinic. Proposed model of monoglyceride (MG) (16:0), MG (18:0), phosphatidylethanolamine (PE) (18:3–16:0), PE (16:0–20:4), and phosphatidylcholine (PC) (O‐16:2–18:3) yielded AUC 1.000 (95% CI, 1.000–1.000), specificity 100% and sensitivity 100% in the diagnosis of SLE from HC. A panel of three lipids molecular PC (18:3‐18:1), PE (20:3–18:0), PE (16:0–20:4) permitted to accurately diagnosis of SLE from RA, with AUC 0.921 (95% CI, 0.828–1.000), 70% specificity, and 100% sensitivity. The plasma lipidomics signatures could serve as an efficient and accurate tool for early diagnosis and provide unprecedented insight into the pathogenesis of SLE.
Abstract 14730: Effects of Diesel Exhaust Fumes Exposure on Vascular Wall Properties Inflammation and Endothelial Function
Authors: Petros Fountoulakis, Evangelos Oikonomou, Sotiris Tsalamandris, Antigoni Milliou, Assimakopoulos Margarita Niki, Nikolaos Barmparesos, Ioannis Giannarakis, Pinelopi Siamata, Dimitrios Tousoulis
Journal: Circulation (2019)

Introduction: Diesel exhaust fumes are harmful toxins affecting the population.Short-term impact of diesel fumes has not been studied. Hypothesis: Acute and short-term (24 h) effects of diesel exha...
DISPROPORTIONATE VERSUS PROPORTIONATE FUNCTIONAL MITRAL REGURGITATION EVALUATION BY MAGNETIC RESONANCE IMAGING AND PROGNOSTIC IMPLICATIONS
Authors: Tom Kai Ming Wang, Duygu Kocyigit, Harry Choi, Nicholas Chan, Chris Anthony, Jennifer Bullen, Joao Cavalcante, Zoran Popovic, Wai Hong Tang, Samir Kapadia, Brian Griffin, Scott Flamm, Deborah Kwon
Journal: Journal of the American College of Cardiology (2021)
Rate of thrombosis in children and adolescents hospitalized with COVID-19 or MIS-C
Authors: Hilary Whitworth, Sarah E. Sartain, Riten Kumar, Katherine Armstrong, Lance Ballester, Marisol Betensky, Clay T. Cohen, Rosa Diaz, Caroline Diorio, Neil A. Goldenberg, Julie Jaffray, Jacquelyn Keegan, Kendra Malone, Adrienne G. Randolph, Stacey Rifkin-Zenenberg, Wendy Seto Leung, Anthony Sochet, Lakshmi Srivaths, Ayesha Zia, Leslie Raffini
Journal: Blood (2021)
Protein Bait Hypothesis: circRNA-Encoded Proteins Competitively Inhibit Cognate Functional Isoforms
Authors: Huanqiang Zhao, Qiongjie Zhou, Xiaotian Li
Journal: Trends in Genetics (2021)

Recent studies have demonstrated that a large group of proteins encoded by circular RNAs (circRNAs) are likely to play a role in cancer development; however, there remains a substantial gap in our understanding of this group of proteins and their functional mechanisms involved. Therefore, we propose the protein bait hypothesis, which specifies that circRNA-encoded proteins compete with their cognate linearly spliced protein isoforms for binding molecules, preventing proper isoform functioning. This hypothesis may expand our understanding of the functional mechanisms of circRNA-encoded proteins and prove useful in elucidating the mechanisms underlying human development, physiology, and diseases, and in parallel, also aid in drug discovery.
IMPACT OF DIABETES MELLITUS AND ITS INTERACTIONS WITH OTHER CARDIOVASCULAR RISK FACTORS ON HEART FAILURE HOSPITALIZATIONS FOLLOWING ACUTE MYOCARDIAL INFARCTION
Authors: Srikanth Yandrapalli, Aaqib Malik, FNU Namratha, Gayatri Pemmasani, Dhrubajyoti Bandyopadhyay, Wilbert Aronow, William Frishman, Howard Cooper
Journal: Journal of the American College of Cardiology (2021)
VALIDATION OF AN ARTIFICIAL INTELLIGENCE ELECTROCARDIOGRAM BASED ALGORITHM FOR THE DETECTION OF LEFT VENTRICULAR SYSTOLIC DYSFUNCTION IN SUBJECTS WITH CHAGAS DISEASE
Authors: Zachi Itzhak Attia, Antonio Ribeiro, Paul Friedman, Maria Carmo Nunes, Paulo Gomes, Ariela Ferreira, Bruno Figueiredo, Ester Sabino, Peter Noseworthy, Suraj Kapa, Pablo Perel, Francisco Lopez-Jimenez
Journal: Journal of the American College of Cardiology (2021)
REFLECTION-MODE PHOTOPLETHYSMOGRAPHY FINGER SENSORS ENABLE ACCURATE TRACKING OF BLOOD PRESSURE TRENDS IN SMARTPHONES WITHOUT REQUIRING A USER CALIBRATION
Authors: Steven Francis LeBoeuf, Lawrence Christopher Eschbach, Tushar Tank, Ryan David Hodges, Namita Lokare, Steven Hauser, Nicki Moncourtois
Journal: Journal of the American College of Cardiology (2021)
Reply to Laura Evangelista and Egesta Lopci’s Letter to the Editor re: Hendrik Van Poppel, Renée Hogenhout, Peter Albers, et al. Early Detection of Prostate Cancer in 2020 and Beyond: Facts and Recommendations for the European Union and the European Commission. Eur Urol 2021;79:327–9: Early Detection of Prostate Cancer in High-risk Patients with Negative Fusion Biopsy
Authors: Hendrik Van Poppel, Renée Hogenhout, Peter Albers, Roderick C.N. van den Bergh, Jelle O. Barentsz, Monique J. Roobol
Journal: European Urology (2021)
Low-Income African American Women With Hypertension and Depression
Authors: Anita Slomski
Journal: JAMA (2021)

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CLINICAL PHENOGROUPS ARE MORE EFFECTIVE THAN LEFT VENTRICULAR EJECTION FRACTION CATEGORIES IN STRATIFYING HEART FAILURE OUTCOMES
Authors: Andreas B. Gevaert, Semra Tibebu, Mamas Mamas, Neal Ravindra, Shun Fu Lee, Tariq Ahmad, Dennis T. Ko, James Januzzi, Harriette Van Spall
Journal: Journal of the American College of Cardiology (2021)