tbuckley/cabot-search huggingface dataset:
Value of partial ejection fraction, volume increment, and regional wall motion in identifying patients with clinically significant coronary artery disease.
Authors: F HSheehan, H TDodge, E LBolson, H WWoo, G RCaputo, D KStewart
Journal: Circulation (1983)

Recent studies suggest that the partial ejection fraction (EF) in early systole is a more sensitive index of left ventricular (LV) dysfunction than the holosystolic EF. We examined LV volume, partial EF, and volume increment at each of 12 time points in systole to determine which parameter best distinguishes normal subjects from patients with coronary artery disease (CAD). Contrast ventriculograms, obtained either in the right anterior oblique projection (60 frames/sec) or in the biplane projection (30 frames/sec), of 58 normal subjects and 68 patients with CAD were studied. The endocardial contour in each frame of a sinus beat was traced to derive a volume curve. At each twelfth of systole, LV volume was extrapolated from the curve and the partial EF was calculated. The increment in volume between successive time points was also calculated. Both partial EF and LV volume in patients with CAD became progressively more abnormal with time; peak abnormality occurred at end-systole. In a subgroup of patients w...
Change of left atrial systolic pressure waveform in relation to left ventricular end-diastolic pressure.
Authors: YMatsuda, YToma, MMatsuzaki, KMoritani, ASatoh, KShiomi, NOhtani, MKohno, TFujii, KKatayama
Journal: Circulation (1990)

The relation between the left atrial systolic pressure waveform and left ventricular end-diastolic pressure was observed in 17 patients who underwent diagnostic cardiac catheterization. Left atrial pressure and left ventricular pressure were simultaneously recorded from a multisensor catheter before and during angiotensin infusion. Left ventricular systolic pressure and left ventricular end-diastolic pressure were 133 +/- 17 and 12.3 +/- 3.2 mm Hg, respectively, before angiotensin infusion and increased to 168 +/- 18 (p less than 0.01) and 19.4 +/- 4.5 mm Hg (p less than 0.01), respectively, during infusion. The left atrial systolic pressure curve consisted of two positive waves--a first wave (A) and a second wave (A'). The A and A' wave pressures were 11.6 +/- 2.3 and 10.2 +/- 3.9 mm Hg, respectively, before angiotensin infusion and 16.5 +/- 2.9 (p less than 0.01) and 18.1 +/- 4.7 mm Hg (p less than 0.01), respectively, during infusion. The ratio of A'/A of left atrial systolic pressure was 0.81 +/- 0.27...
Identification and characterization of guinea pig angiotensin II ventricular and atrial receptors: coupling to inositol phosphate production.
Authors: K MBaker, H ASinger
Journal: Circulation Research (1988)

Angiotensin II elicits a receptor-mediated positive inotropic response in cardiac tissue from most mammalian species by activating voltage-sensitive slow Ca2+ channels. In the guinea pig, we confirm there is no in vitro contractile force development in bioassay systems using isolated hearts or left atrial tissue in response to angiotensin peptides. However, 125I-angiotensin II binding sites that have the characteristics of a membrane receptor were identified in ventricular (myocardial) and atrial membrane preparations from guinea pigs. In ventricles, saturation-binding data yielded an optimal fit to a two-site model with a high-affinity site Kd1 = 3.6 +/- 0.7 nM and a low-affinity site Kd2 = 433 +/- 126 nM and binding capacities of 66 +/- 10 and 821 +/- 49 fmol/mg protein, respectively. In atria, saturation binding data yielded an optimal fit to a two-site model with a high-affinity site Kd1 = 1.6 nM and a low-affinity site Kd2 = 300 nM and capacities of 145 and 752 fmol/mg protein, respectively. The vent...
Manual of Modern Surgery. General and Operative.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparative hemodynamic effects of inotropic and vasodilator drugs in severe heart failure.
Authors: EMikulic, J NCohn, J AFranciosa
Journal: Circulation (1977)

In 12 patients with severe congestive heart failure (CHF) due to ischemic heart disease or nonischemic cardiomyopathy the hemodynamic response to intravenous infusion of sodium nitroprusside (N) was compared to that of dobutamine (D) 10 microgram/kg/min. D and N produced comparable increases in cardiac output (CO) (2.8 to 5.8 L/min and 2.9 to 5.0 L/min, respectively), but, compared to N, D caused a higher arterial pressure (99.3 vs 86.2 mm Hg, P less than 0.01) and heart rate (102.5 vs 95.3, P less than 0.05) and less reduction in pulmonary wedge pressure (PWP) (28.9 to 20.2 mm Hg vs 29.1 to 16.6 mm Hg, P less than 0.05). In five additional patients N and D were studied separately and then were infused together. The combination resulted in a higher CO, lower PWP and greater reduction in systemic and pulmonary vascular resistances than either drug alone. Brachial arterial infusion of nitroprusside produced prominent forearm vasodilation in a dose less than 10% of the systemic dose, whereas vasodilation wit...
Guidelines for the Clinical Diagnosis of Lyme Disease
Authors: Angelina A.M. Blaauw
Journal: Annals of Internal Medicine (1998)

Letters1 September 1998Guidelines for the Clinical Diagnosis of Lyme DiseaseAngelina A.M. Blaauw, MD and Sief van der Linden, MDAngelina A.M. Blaauw, MDUniversity Hospital Utrecht; 3508 GA Utrecht, the NetherlandsUniversity Hospital Maastricht; 6202 AZ Maastricht, the NetherlandsSearch for more papers by this author and Sief van der Linden, MDUniversity Hospital Utrecht; 3508 GA Utrecht, the NetherlandsUniversity Hospital Maastricht; 6202 AZ Maastricht, the NetherlandsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-5-199809010-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The recent position papers on Lyme disease [1, 2] emphasize the importance of the pretest probability of disease in the laboratory evaluation of patients and promote rational diagnosis and treatment. However, several issues deserve more attention. Studies that described results in patients outside North America were excluded for puzzling and untrue reasons [2]. Moreover, the real issue is estimating the pretest probability of disease and application of test characteristics, such as likelihood ratios.We assume that principles of diagnosis and treatment of patients with Lyme disease can be validly extrapolated to regions outside North America. Inclusion of ...References1. Guidelines for laboratory evaluation in the diagnosis of Lyme disease. American College of Physicians. Ann Intern Med. 1997; 127:1106-8. Google Scholar2. Tugwell P, Dennis DT, Weinstein A, Wells G, Shea B, Nichol G, et al. Laboratory evaluation in the diagnosis of Lyme disease. Ann Intern Med. 1997; 127:1109-23. Google Scholar3. Blaauw AA, Nohlmans MK, van den Bogaard AE, van der Linden S. Diagnostic tools in Lyme borreliosis: clinical history compared with serology. J Clin Epidemiol. 1992; 11:1229-36. Google Scholar4. Blaauw AA, Dijkmans BA, Bouma PA, van der Linden S. Rational diagnosis and treatment in unclassified arthritis: how clinical data may guide requests for Lyme serology and antibiotic treatment. Ann Rheum Dis. 1993; 52:206-10. Google Scholar5. Fahrer H, van der Linden SM, Sauvain MJ, Gern L, Zhioua E, Aeschlimann A. The prevalence and incidence of clinical and asymptomatic Lyme borreliosis in a population at risk. J Infect Dis. 1991; 163:305-10. Google Scholar Author, Article, and Disclosure InformationAffiliations: University Hospital Utrecht; 3508 GA Utrecht, the NetherlandsUniversity Hospital Maastricht; 6202 AZ Maastricht, the Netherlands PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1998Volume 129, Issue 5Page: 423KeywordsArthritisEnzyme linked immunosorbent assayEpidemiologyInflammatory arthritisLikelihood ratioLyme diseasePatientsResearch laboratoriesSerologyTreatment guidelines Issue Published: 1 September 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
The behavior of sonicated albumin microbubbles within the microcirculation: a basis for their use during myocardial contrast echocardiography.
Authors: M WKeller, S SSegal, SKaul, BDuling
Journal: Circulation Research (1989)

The purpose of this study was to determine whether the behavior of sonicated albumin microbubbles accurately mimics red blood cell flow in the microcirculation and is thus consistent with their use as in vivo tracers of red blood cell flow during myocardial contrast echocardiography. Accordingly, microbubbles prepared from fluorescein-conjugated albumin and fluorescently labeled red blood cells were injected intravascularly in eight golden hamsters. Their intravascular distribution, velocities, arteriolar-to-venular transit and flux ratios at branch points were determined in the microcirculation of the cheek pouch. Albumin microbubbles (mean diameter, 4.9 +/- 3.6 microns) and red blood cells displayed a similar frequency of distribution across the arteriolar lumen (33% in the central 20% of the arterioles), and their arteriolar velocities were also similar (2.5 +/- 0.7 mm/sec and 2.3 +/- 0.7 mm/sec,p = NS). The mean velocities of microbubbles correlated well with those of red blood cells at baseline and a...
Reply to The small molecule CLP257 does not modify activity of the K+–Cl− co-transporter KCC2 but does potentiate GABAA receptor activity
Authors: Martin Gagnon, Marc J Bergeron, Jimena Perez-Sanchez, Isabel Plasencia-Fernández, Louis-Etienne Lorenzo, Antoine G Godin, Annie Castonguay, Robert P Bonin, Yves De Koninck
Journal: Nature Medicine (2017)
Noninvasive evaluation of the ratio of pulmonary to systemic flow in atrial septal defect by duplex Doppler echocardiography.
Authors: AKitabatake, MInoue, MAsao, HIto, TMasuyama, JTanouchi, TMorita, MHori, HYoshima, KOhnishi
Journal: Circulation (1984)

The ratio of pulmonary to systemic flow (Qp/Qs) was noninvasively evaluated by duplex Doppler echocardiography in 22 patients with atrial septal defects (ASDs). Right and left ventricular stroke volumes (RSV, LSV) were determined from the recordings of ejection blood flow velocity and diameter at the level of the pulmonary and aortic orifices in each ventricular outflow tract. The ratio RSV/LSV, determined by the duplex Doppler echocardiography, was compared with Qp/Qs by oximetry. The RSV/LSV for 10 normal subjects was 0.99 +/- 0.05 (mean +/- SD), whereas the RSV/LSV for patients with ASD, 2.26 +/- 0.63, was significantly higher than that for normal subjects (p less than .01). In patients with ASD, a fairly good correlation was found between RSV/LSV and Qp/Qs (r = .92, p less than .01; y = 1.11x - 0.30), and this high correlation was found even in patients with complications such as pulmonary hypertension, mitral and tricuspid regurgitation, Eisenmenger complex, and ventricular septal defect. We also fou...
Intracellular alkalinization induced by bradykinin sustains activation of the constitutive nitric oxide synthase in endothelial cells.
Authors: IFleming, MHecker, RBusse
Journal: Circulation Research (1994)

The transient increase in [Ca2+]i in endothelial cells after stimulation with bradykinin can account for the initiation but not the sustained production of nitric oxide (NO). Therefore, we investigated whether this sustained activation of the constitutive NO synthase (cNOS) could be mediated by an increase in pHi, which is induced by an activation of the Na(+)-H+ exchanger rather than an increase in [Ca2+]i. Cultured human endothelial cells grown on coverslips were loaded with either C.SNAFL-2 or fura 2-AM for fluorometric analysis of either pHi or [Ca2+]i. NO release was assayed by the ability of effluent from endothelial cells to stimulate purified soluble guanylyl cyclase. The pH dependence of a microsomal cNOS preparation was determined by assay of L-[3H]citrulline formation from L-[3H]arginine. Bradykinin (10 nmol/L) induced a biphasic change in endothelial pHi consisting of an initial acidification followed by a prolonged alkalinization above resting values. Inhibition of the Na(+)-H+ exchanger usin...
Niv Score Is A Reliable Index For Evaluating Small Bowel Involvement In Pediatric Crohn’S Disease Patients
Authors: G Hauser, G Palcevski, B Candrlic, D Miletic, P Hrabac
Journal: Endoscopy (2021)

Aims Crohn’s disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract, predominantly involving the small intestine and colon. Up to 66 % of patients with Crohn’s disease have small-bowel involvement at diagnosis. Ileocolonoscopy is the gold standard in the diagnosis of ileocolonic disease but skip lesions and proximal involvement can be evaluated only by the meaning of capsule endoscopy (VCE) and or MR enterography (MRE). The aim of the study was to correlate findings obtained from MRE and VCE with Paediatric Crohn’s disease Activity Index (PDCAI) at the time of disease presentation.
Identification of reentry circuit sites during catheter mapping and radiofrequency ablation of ventricular tachycardia late after myocardial infarction.
Authors: W GStevenson, HKhan, PSager, L ASaxon, H RMiddlekauff, P DNatterson, IWiener
Journal: Circulation (1993)

BACKGROUNDVentricular tachycardia reentry circuits in chronic infarct scars can contain slow conduction zones, which are difficult to distinguish from bystander areas adjacent to the circuit during catheter mapping. This study developed criteria for identifying reentry circuit sites using computer simulations. These criteria then were tested during catheter mapping in humans to predict sites at which radiofrequency current application terminated ventricular tachycardia.METHODS AND RESULTSIn computer simulations, effects of single stimuli and stimulus trains at sites in and adjacent to reentry circuits were analyzed. Entrainment with concealed fusion, defined as ventricular tachycardia entrainment with no change in QRS morphology, could occur during stimulation in reentry circuit common pathways and adjacent bystander sites. Pacing at reentry circuit common pathway sites, the stimulus to QRS (S-QRS) interval equals the electrogram to QRS interval (EG-QRS) during tachycardia. The postpacing interval from th...
Determinants of loaded shortening velocity in single cardiac myocytes permeabilized with alpha-hemolysin.
Authors: N KSweitzer, R LMoss
Journal: Circulation Research (1993)

Force-velocity relations were obtained from single cardiac myocytes isolated by enzymatic digestion of rat myocardium and permeabilized with the pore-forming staphylococcal toxin alpha-hemolysin. Single cardiac myocytes were attached to a force transducer and piezoelectric translator and viewed with an inverted microscope to allow periodic monitoring of sarcomere length during experiments. Permeabilized cells were activated by immersion in a bath of known [Ca2+]. We report that the Ca2+ sensitivity of cells obtained by enzymatic digestion and permeabilized using alpha-hemolysin is similar to that reported previously for mechanically disrupted ventricular myocardium; however, the tension-pCa relation is less steep in the new preparation. During isotonic measurements, force was clamped to various loads using a rapid-response servo system. All recordings of shortening under load were distinctly curvilinear, and analysis of data involved fitting each shortening recording with a single exponential curve and ca...
The effect of ouabain on the isolated sinus node preparation of the rabbit studied with microelectrodes.
Authors: GSteinbeck, F IBonke, M AAllessie, W JLammers
Journal: Circulation Research (1980)

In 30 isolated, spontaneously beating right atrial preparations of the rabbit, the arrhythmogenic actions of ouabain were studied with microelectrodes. Ouabain (10(-6) M) uniformly produced the following events: (1) a gradual increase in sinus rate with periods of alternation of beta-to-beat atrial intervals, (2) a rapid rate and regular rhythm, (3) severe irregularity of rhythm, (4) total atrial arrest. Cycle length decreased from 394 msec +/- 43 (mean +/- SD) during control to 229 msec +/- 26 during the period of rapid rate and regular rhythm (P less than 0.001). Pretreatment with atropine or propranolol did not abolish this positive chronotropic action of ouabain. Maps of the spread of activation in the area of the sinus node in eight experiments revealed that the speeding up of rate is accompanied by a shift of dominant pacemaker site toward the sinoatrial border. In explanation, it is shown that sinoatrial border fibers develop strong diastolic depolarization, whereas dominant pacemaker fibers do so ...
RPL11 Haploinsufficient Mice Have a CFU-E/Proerythroblast Block, Elevated Erythroblast Heme, Reduced Gata1, and Increased Ribosomal Protein Gene Expression
Authors: Raymond Doty, Xiaowei Yan, Christopher Lausted, Qiang Tian, Janis L. Abkowitz
Journal: Blood (2017)
Angiographic prevalence of high-risk coronary artery disease in patient subsets (CASS).
Authors: B RChaitman, M GBourassa, KDavis, W JRogers, D HTyras, RBerger, J WKennedy, LFisher, M PJudkins, M BMock, TKillip
Journal: Circulation (1981)

The prevalence of coronary artery stenoses greater than or equal to 70% or left main stenosis greater than or equal to 50% was evaluated in 20,391 patients who underwent angiography in the Coronary Artery Surgery Study from 1975-1979. After the patients with unstable angina or myocardial infarction were excluded, the disease prevalence in the 8157 patients with definite angina, probable angina, and nonspecific chest pain was 93%, 66% and 14% in men and 72%, 36% and 6% in women (p less than 0.001). The age and sex of the patients and character of chest pain were important determinants of disease prevalence and severity. Left main or three-vessel coronary disease occurred in more than 50% of middle-aged men and older women with definite angina and in more than 50% of men who had probable angina and were older than 60 years of age. In contrast, left main coronary disease occurred in less than 2% of 1282 men and less than 1% of 1397 women with nonspecific chest pain regardless of age. In this latter patient s...
Understanding the Origins of Loss of Protein Function by Analyzing the Effects of Thousands of Variants on Activity and Abundance
Authors: Matteo Cagiada, Kristoffer E Johansson, Audrone Valanciute, Sofie V Nielsen, Rasmus Hartmann-Petersen, Jun J Yang, Douglas M Fowler, Amelie Stein, Kresten Lindorff-Larsen
Journal: Molecular Biology and Evolution (2021)

Understanding and predicting how amino acid substitutions affect proteins are keys to our basic understanding of protein function and evolution. Amino acid changes may affect protein function in a number of ways including direct perturbations of activity or indirect effects on protein folding and stability. We have analyzed 6,749 experimentally determined variant effects from multiplexed assays on abundance and activity in two proteins (NUDT15 and PTEN) to quantify these effects and find that a third of the variants cause loss of function, and about half of loss-of-function variants also have low cellular abundance. We analyze the structural and mechanistic origins of loss of function and use the experimental data to find residues important for enzymatic activity. We performed computational analyses of protein stability and evolutionary conservation and show how we may predict positions where variants cause loss of activity or abundance. In this way, our results link thermodynamic stability and evolutionary conservation to experimental studies of different properties of protein fitness landscapes.
New Option In The Approach Of Pancreatic Necrosis
Authors: V Gamelas, S Santos, I Canha, D Carvalho, G Ramos
Journal: Endoscopy (2021)

The approach of acute pancreatitis complications, such as walled-off necrosis, is challenging and the poor prognosis may be improved by using minimally invasive techniques. After transgastric endoscopic drainage with the placement of a lumen-apposing metal stent, the necrotic site may be accessed for endoscopic necrosectomy. The instruments available were originally designed for other uses, not always providing adequate visual control and removal of necrotic fragments. The EndoRotor (Interscope Medical, Inc), is a recently proposed instrument, which allows to cut and simultaneously aspirate the necrotic content.
140P Prognostic and predictive value of co-mutational profile in advanced EGFR positive NSCLC patients treated with TKIs
Authors: M.L. Reale, P. Bironzo, L. Righi, A. Listi, F. Tabbò, A. Caglio, C. Pisano, V.M. Napoli, M. Di Maio, S. Novello
Journal: Journal of Thoracic Oncology (2021)
We Have “Gifted” Enough: Indigenous Genomic Data Sovereignty in Precision Medicine
Authors: Krystal S. Tsosie, Joseph M. Yracheta, Jessica A. Kolopenuk, Janis Geary
Journal: The American Journal of Bioethics (2021)

This article is referred to by:Response to Open Peer Commentaries: Distinguishing the "Gift" from "Donation" as a Path toward Reciprocity and Relational Ethics
Ischemic preconditioning is associated with a delay in ischemia-induced reduction of beta-adrenergic signal transduction in rabbit hearts.
Authors: TIwase, TMurakami, TTomita, SMiki, KNagai, SSasayama
Journal: Circulation (1993)

BACKGROUNDIt has been reported that the A1-adenosine receptor mediates the cardioprotective effect of ischemic preconditioning. This receptor couples inhibitory guanine nucleotide-binding protein (Gi) and inhibits adenylate cyclase activity. However, the role of adenylate cyclase in preconditioning is unknown.METHODS AND RESULTSWe compared the effects of ischemia on the sarcolemmal beta-adrenergic receptor density (Bmax), the stimulatory guanine nucleotide-binding protein (Gs) activity as determined by reconstitution with S49 lymphoma cyc- membranes, and baseline and maximally stimulated adenylate cyclase activities (ACAs) in control and preconditioned rabbit hearts. The control population (n = 28) received 0, 10, 20, and 60 minutes of coronary occlusion (n = 6 to 8 per stage), and preconditioned rabbits (n = 24) received two cycles of alternating 5-minute occlusion and reperfusion before sustained ischemia (n = 6 per stage). In control hearts, occlusion induced rapid and progressive reductions in the Bma...