tbuckley/cabot-search huggingface dataset:
Hair loss and contraceptives.
Journal: BMJ (1973)

In a review of the relationship of hair loss to oral contraceptive (OC) use, several studies are examined. The effect of pregnancy on hair loss has been substantiated. After the 3rd month of pregnancy the proportion of follicles in active growth rises. Increased shedding follows childbirth due to the delayed physiological passage of some follicles into the resting phase, blood loss, and sometimes anticoagulants. In contraceptive studies it can be shown that in 1/2 of the patients there was a temporary increase in the proportion of resting during early treatment but that pretreatment status was regained in 6 months. In 11 patients in this study who showed high pretreatment levels of resting follicles, the proportion of actively growing follicles actually increased with OCs. The incidence of diffuse alopecia in women between 1952 and 1971 has remained unchanged although OC use has increased. This suggests the effect of OCs on alopecia is insignificant. There may be a causal relationship between stopping estrogen and hair loss. However, it may be possible that genetically suseptible women might be affected by OCs. In patients where hair loss is accompanied by seborrhea or where there is hirsuitism it is suggested that the pill be discontinued.
Abstracts cont.
Authors: A Makri, X Agathokleous, H Papavasileiou, F Lykou, N Manios, A Voyatzi, E Voinova, Z Sekawi, G Vinomarlini, N Mariana, D Shamala, K Thilakavathy, R Hresic-Krsulovic, B Sim, E Berberovic, P Koudounis, M Pagkalou, C Mendes, C Oplustil, J Sampaio, P Garbes, P Lima, L Pedneault, C Kiffer, Sao Paulo
Journal: Clinical Microbiology and Infection (2005)
EULAR points to consider when analysing and reporting comparative effectiveness research using observational data in rheumatology
Authors: Delphine Sophie Courvoisier, Kim Lauper, Joanna Kedra, Maarten de Wit, Bruno Fautrel, Thomas Frisell, Kimme L Hyrich, Florenzo Iannone, Pedro M Machado, Lykke Midtbøll Ørnbjerg, Ziga Rotar, Maria Jose Santos, Tanja A Stamm, Simon R Stones, Anja Strangfeld, Sytske Anne Bergstra, Robert B M Landewé, Axel Finckh
Journal: Annals of the Rheumatic Diseases (2022)

Comparing treatment effectiveness over time in observational settings is hampered by several major threats, among them confounding and attrition bias.To develop European Alliance of Associations for Rheumatology (EULAR) points to consider (PtC) when analysing and reporting comparative effectiveness research using observational data in rheumatology.The PtC were developed using a three-step process according to the EULAR Standard Operating Procedures. Based on a systematic review of methods currently used in comparative effectiveness studies, the PtC were formulated through two in-person meetings of a multidisciplinary task force and a two-round online Delphi, using expert opinion and a simulation study. Finally, feedback from a larger audience was used to refine the PtC. Mean levels of agreement among the task force were calculated.Three overarching principles and 10 PtC were formulated, addressing, in particular, potential biases relating to attrition or confounding by indication. Building on Strengthening the Reporting of Observational Studies in Epidemiology guidelines, these PtC insist on the definition of the baseline for analysis and treatment effectiveness. They also focus on the reasons for stopping treatment as an important consideration when assessing effectiveness. Finally, the PtC recommend providing key information on missingness patterns.To improve the reliability of an increasing number of real-world comparative effectiveness studies in rheumatology, special attention is required to reduce potential biases. Adherence to clear recommendations for the analysis and reporting of observational comparative effectiveness studies will improve the trustworthiness of their results.
Erroneous commitment
Authors: A. R. Holder
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TCT-576 Plaque Rupture is Associated with Larger Infarct Size Following Successful Percutaneous Coronary Intervention in ST-segment Elevation Acute Myocardial Infarction
Authors: Keisuke Satogami, Yasushi Ino, Yuichi Ozaki, Yasutsugu Shiono, Kunihiro Shimamura, Makoto Orii, Yamano Takashi, Takashi Tanimoto, Tomoyoshi Yamaguchi, Kumiko Hirata, Takashi Kubo, Toshio Imanishi, Takashi Akasaka
Journal: Journal of the American College of Cardiology (2013)
Clinical Outcomes in Biopsy-Proven Nonalcoholic Fatty Liver Disease Patients: A Multicenter Registry-based Cohort Study
Authors: Hideki Fujii, Michihiro Iwaki, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Miwa Kawanaka, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Sakura Yamamura, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Norifumi Kawada, Akihiro Tokushige, Yoshihiro Kamada, Hirokazu Takahashi, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takeshi Okanoue
Journal: Clinical Gastroenterology and Hepatology (2022)
Abstract P342: Associations Between Sleep Duration and Sleep Quality and Long-Term Weight Status in Post-Bariatric Surgery Patients
Authors: Elsa Thomas, Devon Roeshot, Dympna Gallagher, Marie-Pierre St-Onge
Journal: Circulation (2018)

Introduction: The prevalence of obesity continues to rise since 1980. This obesity epidemic has been paralleled by a trend of reduced sleep duration and sleep quality throughout the years. However, there is limited research on the relation between sleep duration and quality and its association with weight loss maintenance. The purpose of this study was to examine the association between sleep duration and quality and weight status in post-bariatric surgery patients at 9-y post-surgery. We tested the hypothesis that participants’ post-surgical weight change would be related to sleep duration and quality at 9-y. Methods: Sleep data were collected on a subset of participants (mean body weight = 94.1 kg ± 18.9) enrolled in an ancillary study to the Longitudinal Assessment for Bariatric Surgery trial. Self-reported hours of sleep per night and overall sleep quality were assessed once, at the 9-y visit using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. Results: Complete data were available on 14 participants (10 females and 4 males, age 52.1 ± 15.6 y), current weight 94 kg ± 18.9. Average total weight loss from pre-surgery was 28.5% ± 10.6, with an average weight gain of 0.3 ± 6.2 % over the last 2 y of follow-up. Participants reported average sleep duration of 6.8 ± 2.0 h/night at the 9-y evaluation visit and an average score of 7.9 ± 3.7 on the PSQI. There was no relation between sleep duration and current weight or percent weight change after maximum weight loss, which occurred around 2-y post-surgery. However, there were trends for an association between sleep quality and percent weight change after maximum weight loss (p=0.057) and percent weight change in the last 2-y of follow-up (p=0.066). In general, participants who lost more weight over the last 2 y of the study had lower scores on the PSQI, indicating better quality of sleep. Conclusion: Our results showed no association between sleep quality or duration and long-term changes in weight for patients who underwent bariatric surgery. However, those with better sleep quality tended to have more beneficial changes in weight over the latest 2-y. It is important to note that this study cannot address causality and whether improved weight influenced sleep quality or whether sleep quality influenced weight change. Further studies should examine the temporality of these association. Sleep quality may be an important sleep metric to consider for long-term weight loss maintenance.
Typographic Error in Results
Journal: JAMA Network Open (2021)

Teresa W. Wang, PhD; Andrea S. Gentzke, PhD; Linda J. Neff, PhD; Emily V. Glidden, MPH; Ahmed Jamal, MBBS; Eunice Park-Lee, PhD; Chunfeng Ren, PhD; Karen A. Cullen, PhD; Brian A. King, PhD; Karen A. Hacker, MD
Single-center real-world treatment and outcomes in patients with hepatocellular carcinoma receiving immunotherapy.
Authors: Diane Habib, Ronak Patel, Sandra Algaze, Syma Iqbal, Victor Yundeh Chiu, Anthony B. El-Khoueiry
Journal: Journal of Clinical Oncology (2022)

401 Background: Immune checkpoint inhibitor (ICI) based therapy has emerged as a therapeutic option in hepatocellular carcinoma (HCC). Approvals were based on clinical trials with strict eligibility criteria limiting generalizability to clinical practice. Further, there is no established post ICI treatment standard. Methods: Patients (pts) with advanced HCC treated with ICI as single agent (ICI-SA) or in combination (ICI-C) across lines of therapy were included in this retrospective study. Results: The cohort consisted of 118 pts: median age 63 years (24, 88); 84% male; 35% Hispanic/Latino, 26% Asian, 19% Non-Hispanic White, 5% Black and 15% unknown. Etiology of cirrhosis: 13% Hepatitis B, 45% Hepatitis C, 16 % alcohol liver disease, 10% NAFLD and 16 % mixed/other; 73% had baseline Child Pugh (CP) A, 25% had CP-B, and 2% had CP-C; ALBI Scores were ≤ -2.60 in 32%, 2.60 &lt; and ≤-1.39 in 48%, and ≥-1.39 in 19% pts; 62% had extrahepatic disease and/or portal invasion; AFP was ≥ 400 ng/mL in 25% of pts. 81% of pts had prior local therapy. First line systemic therapies were: TKIs in 52 pts (44%), ICI-SA in 42 (36%), ICI-C in 15 (13%), clinical trial agent (CTA) in 8 (7%) and chemotherapy in 1 (1%), with a median duration (dur) of 4 months (95% CI 2.3 to 4). Ninety one (77%) and 61 pts (52%) received ≥ 2 or 3 lines of therapy, respectively. Fifty seven pts had ICI-SA and 14 ICI-C in second line or beyond. Median dur of ICI therapy was 4 months (95% CI 3-5) for all lines. Post-ICI therapies included 11% ICI, 30% CTA and 59% TKIs. TKIs included sorafenib (46%), cabozantinib (27%), lenvatinib (15%), and regorafenib (27%). For the 118 pt cohort, mOS was 14 months (95% CI 12-19). For pts treated with ICI in first line, mOS was 11 months (0, 74); post-ICI mOS was 6 months (95% CI 3-9) and mPFS was 3 months (95% CI 2-3). Thirty one pts received a TKI post ICI; mOS for this subset was 19 months (15, 22); mOS from start of TKI post ICI was 6.5 months (4, 12). On multivariable regression analysis, ALBI score was associated with OS (HR 1.63, p=0.02, CI: 1.08-2.27). Conclusions: Pts with advanced HCC and CP-A or B cirrhosis are able to receive sequential systemic therapy including ICI. Survival outcomes in this cohort are impacted by the inclusion of patients with more compromised liver function and less restrictive pt selection compared to clinical trials. Usage of TKIs post ICI is feasible with suggestion of clinical activity but this is an area in need of prospective studies.
Reverse remodeling of the left ventricle after biventricular pacing in patients with advanced heart failure is related to intraventricular resynchronization: A mechanistic study by tissue doppler imaging Cheuk-Man Yu, Chu-Pak Lau, Hung-Fat Tse, Man-Oi Tang, Hua Yang, Elaine M. C. Chau, Kathryn Fan, Kathy L. F. Lee, Michael R. S. Hill. The University of Hong Kong, Hong Kong, Hong Kong
Journal: Journal of the American College of Cardiology (2001)
A case of abnormal thirst.
Journal: BMJ (1973)

PROFESSOR RUSSELL FRASER (1): We are going to consider a 12-year-old boy (fig.la) who came to this hospital in February 1971 because of abnormal behaviour, poor growth, and refusal of both food and liquids.When he was 10 years and 4 months old he had a period of polyuria and polydipsia with about 10 pints (5-7 1.) intake per day, for which he was admitted to another hospital, where diabetes insipidus was diagnosed.He had haemo-concentrated serum (Na 147 mN).After 8 hours' water deprivation he lost 4 lb (1-8 kg) while when he was given pitressin tannate he produced concentrated urine and lost his thirst.During the subsequent year he grew only I in (1-25 cm) and he began to develop behaviour problems: he could not concentrate on his lessons, and was generally very distractable.His school progress was poor and there were several problems involving stealing and other behaviour disorders.Then a curious change in his attitude towards water occurred: he lost his severe thirst, developed an aversion to fluids, and had to be encouraged to drink.He was admitted to the Radcliffe Infirmary in Oxford, where he was found to be dehydrated, drowsy, and stuporose, but showed no localizing neurological signs.Full examination was done there, including an air encephalogram, and perhaps Dr. Doyle will show us the Oxford x-ray films.DR.F. H. DOYLE (2): The plain radiographs of the skul and pituitary fossa taken at the beginning of May 1970 showed no abnormality.An air encephalogram, performed under general anaesthesia, provided a good demonstration of the basal cisterns and of the anterior end of the third ventricle.This examination showed no evidence of a mass in the region of the hypothalamus.
Research brief
Authors: Dara Mohammadi
Journal: The Lancet Infectious Diseases (2017)

A cocktail of bacteria-killing viruses can prevent cholera infection in animal models. That's according to US scientists who infected baby mice and baby rabbits with an oral dose of three bacteriophages that retain their ability to kill Vibrio cholerae in the small intestine, the site of infection in people. The animals received the cocktail 3–24 h before infection, none had cholera symptoms. The bacteriophages destroy virulence factors on the surface of the bacteria. It's a checkmate of a treatment strategy: for the bacteria to evolve resistance they need mutations in these surface proteins—a change that will likely make them less infectious.
Patient care satisfaction and emergency room utilization among young adult colorectal cancer survivors during the SARS-CoV-2 pandemic.
Authors: Dalia Kagramanov, Kimberly Ann Miller, Phuong Gallagher, David R. Freyer, Joel Milam, Heinz-Josef Lenz, Afsaneh Barzi
Journal: Journal of Clinical Oncology (2022)

34 Background: Survivors of colorectal cancer (CRC) are at risk for late effects of therapy and recurrence of cancer. With recurrence rates ranging between 30-40% (Siegal et al., 2020), consistent, survivor-focused follow-up care is needed for early detection of late effects and recurrence (Jeffery et al., 2019). CRC-related care delivery has been significantly disrupted by the SARS-CoV-2 pandemic, with decreases of 40% in CRC services in the United States between April 2020 and 2019 (Jammu, 2020). Consequentially, survivors may be left with fewer options for care, potentially causing increases in emergency room (ER) utilization. Methods: This cross-sectional study examined the patterns of ER utilization during the SARS-CoV-2 pandemic among young adult CRC survivors and assessed the relationship between self-reported care satisfaction and ER use. Eligible participants were diagnosed with colon or rectal cancer between 18-39 years, between 6-36 months from diagnosis/relapse, English speaking, and based in the United States. Questions on care satisfaction were Consumer Assessment of Healthcare Providers and Systems (CAHPS) questions. A multivariable logistic regression was conducted to assess the association between patient satisfaction and ER utilization, adjusting for factors related to the pandemic. Covariates for this analysis were chosen based on a significance of p &lt; 0.1 at the univariate level, as well as general clinical significance. Results: The overall sample was N = 196, mean age (SD) was 32.1 years (4.5), and 116 survivors (59%) were male. Tumor location was colon or rectal in 42% and 57%, respectively, and the majority (56%) were diagnosed with stage 2 disease; 42.6% reported relapsed disease, and 20% had an ostomy. The majority of survivors (72.5%) had between 1-4 visits to an emergency room in the last 12 months and were categorized as normal users. Approximately 24.7% of the sample had greater than 4 visits to the ER in the last 12 months and were categorized as super-utilizers (Johnson et al., 2015). Colorectal cancer survivors that reported a delay in their follow-up cancer care as a result of the pandemic were two times (OR: 2.05, 95% CI 0.99, 4.24) more likely to be super-utilizers of the ER. Higher self-reported satisfaction with overall care was associated with a 13.7% (OR: 0.86, 95%CI: -0.68, 1.09) lower likelihood of being a super-utilizer. Conclusions: This study found strong associations between delays in care, self-reported care satisfaction, and being a super-utilizer of the ER during the pandemic among young adult CRC survivors off treatment. Increasing patient satisfaction and minimizing care interruptions amongst this vulnerable population may aid in mitigating over-utilization in the ER during an ongoing pandemic.
<i>Starr on Nervous Diseases.</i>Organic and Functional Nervous Diseases. By M. Allen Starr, M. D., Ph.D., LL. D., Professor of Neurology in the College of Physicians and Surgeons, New York; ex-President of the American Neurological Association and of the New York Neurological Society. Second edition, thoroughly revised. Octavo, 824 pages, with 282 engravings and 26 full-page plates. (Philadelphia and New York: Lea Brothers &amp; Co., 1907.)
Authors: L. F. B.
Journal: American Journal of Psychiatry (1907)
Table of Contents
Authors: Dulce Barrios, Mytrang Do, Gregory Phillips, Michael Postow, Tomoko Akaike, Paul Nghiem, Mario Lacouture, Amaris Geisler, Jennifer Wu, Donald Leung, Andrea Moy, Jeffrey Kern, Dirk Elston, Warren Heymann, Elena Hawryluk, Danna Moustafa, Diana Bartenstein, Meera Brahmbhatt, Kelly Cordoro, Laura Gardner, Abigail Gauthier, Douglas Grossman, Deepti Gupta, Raegan Hunt, Melinda Jen, Pei-Chi Kao, Lacey Kruse, Leslie Lawley, Wendy London, Danny Mansour, Judith O'haver, Thuy Phung, Elena Pope, Harper Price, Tova Rogers, Sonal Shah, Zachary Wolner, Jennifer Huang, Ashfaq Marghoob, Jerry Shapiro, Anthony Ho, Kumar Sukhdeo, Lu Yin, Kristen Sicco, Yuna Son, Ernest Owen, Nicandro Phillips, Kristin Price, Laurence Rosenberg, Branko Stefanovic, Christopher Wolfe, Samir Shaath, Amit Om, George Cohen, Akash Gunjan, Nina Van Beek, Tarek Fuhrmann, Susanne Lemcke, Stephanie Goletz, Christian Probst, Lars Komorowski, Giovanni Zenzo, Marian Dmochowski, Kossara Drenovska, Michael Horn, Hana Jedlickova, Cezary Kowalewski, Ljiljana Medenica, Dedee Murrell, Aikaterini Patsatsi, Shamir Geller, Soner Uzun, Snejina Vassileva, Xuejun Zhu, Kai Fechner, Detlef Zillikens, Winfried Sto ¨cker, Enno Schmidt, Kristin Rentzsch, John Frew, Kristina Navrazhina, David Grand, Mary Ba, Patricia Sullivan-Whalen, Sandra Gilleaudeau, Jonathan Garcet, James Ungar, Jonathan Silverberg, Donald Lei, Muhammad Yousaf, Sherief Janmohamed, Paras Vakharia, Rishi Chopra, Rajeev Chavda, Sylvie Gabriel, Kevin Patel, Vivek Singam, Robert Kantor, Derek Hsu, David Cella, Alana Deutsch, Yevgeniy Balagula, Beth Mclellan, Vivien He ´bert, Anne -Be, ´dicte Duval-Modeste, Pascal Joly, Lucie Cellier, Fabienne Jouen, Benoit Veber, Laurent Drouot, Olivier Boyer, Ulrich Mrowietz, Elisabeth Riedl, Stefan Winkler, Wen Xu, Himanshu Patel, Noah Agada, Mark Lebwohl, Claire Alexanian, Anne Zhuang, Milene Crispin, April Armstrong, Daniel Eisen, Thomas Bettuzzi, Laure Frumholtz, Marie Jachiet, ´mence Lepelletier, Mourad Djermane, Florence Cordoliani, Anne Saussine, Jean-David Bouaziz, Herve ´bachelez, Marissa Baranowski, Salma De La Feld, Howa Yeung, Suephy Chen, Connie Zhong, Chandrajit Raut, Robert Glynn, Vinod Nambudiri, Laura Ragmanauskaite, Qi Zhang, Jin Kim, Vin Tangpricha, Darios Getahun, Michael Silverberg, Michael Goodman, Dmitriy Timerman, Nina Antonov, Ali Dana, Stephanie Gallitano, Jesse Lewin, Ana Claudia, Pompeu Raminelli, Andre Rodrigues-Oliveira, Rodrigo Yokota, Juliana Sumita, Diogo Oliveira-Silva, Gustavo Wambier, Edileia Bagatin, Ricci Leonardi, Vincenzo Piccolo, Bianca Piraccini, Giuseppe Argenziano, Teresa Russo, Aurora Alessandrini, Michela Starace, John Plante, Chelsea Eason, Alan Snyder
Journal: Journal of the American Academy of Dermatology (2020)
D-dimer and spiral CT strategy in the diagnosis of pulmonary embolism: a prospective trial Gerard D. Pacouret, Benedicte Delahousse, Daniel Alison, Veronique Eder, Anne Delhomais, Jean Marie Potier, Yves Gruel, Bernard Charbonnier. TROUSSEAU HOSPITAL, TOURS, France
Journal: Journal of the American College of Cardiology (2001)
National trends in quality of care for acute myocardial infarction (AMI) between 1994?1995 and 1998?1999 Dale R. Burwen, Deron H. Galusha, Jennifer M. Lewis, Harlan M. Krumholz, Marjorie R. Bedinger, Martha J. Radford. Health Care Financing Administration, Baltimore, MD, Qualidigm, Middletown, CT
Journal: Journal of the American College of Cardiology (2001)
Prevalence trends of non-alcoholic fatty liver disease among young men in Korea: A Korean military population-based cross-sectional study
Authors: Jaejun Lee, Taeyun Kim, Hyun Yang, Si Hyun Bae
Journal: Clinical and Molecular Hepatology (2022)

Non-alcoholic fatty liver disease (NAFLD) has become a major concern in Korea since its emergence as a dominant cause of chronic liver disease. However, no study has explored its prevalence in adults under 30 years of age. Therefore, we performed a cross-sectional study to investigate the prevalence of NAFLD in Korean men in their early 20s.We collected data of 596,359 Korean soldiers who participated in a health examination between January 2015 and July 2021. A total of 571,872 individuals were analyzed after excluding those with missing data and hepatitis B antigen positivity. Hepatic steatosis was determined using the hepatic steatosis index (HSI). Participants with HSI >36 were considered to have NAFLD.All participants were men, and the mean age was 20.9±1.3 years. Of the 571,872 participants screened, 77,020 (13.47%) were classified as having NAFLD. The prevalence of NAFLD consistently increased from 2015 to 2021 (10.66% vs. 16.44%, P<0.001). Increases from 2015 to 2021 were also noted in the prevalence of hypercholesterolemia, hyperglycemia, and hypertension (P<0.001 for all). The mean body mass index also increased from 23.3±3.0 kg/m2 to 23.9±3.1 kg/m2 between 2015 and 2021 (P<0.001).The prevalence of NAFLD and of other metabolic dysfunctions in Korean men in their early 20s increased from 2015 to 2021.