Metformin Prescription for Insured Adults With Prediabetes From 2010 to 2012
Authors: Tannaz Moin, O. Kenrik Duru, Carol M. Mangione
Journal: Annals of Internal Medicine (2015)

Letters15 September 2015Metformin Prescription for Insured Adults With Prediabetes From 2010 to 2012Tannaz Moin, MD, MBA, MSHS, O. Kenrik Duru, MD, MSHS, and Carol M. Mangione, MD, MSPHTannaz Moin, MD, MBA, MSHSFrom Veterans Affairs Greater Los Angeles Health System, Veterans Affairs Health Services Research and Development Service Center for the Study of Healthcare Innovation, Implementation & Policy, and David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California;and David Geffen School of Medicine and Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, Los Angeles, California., O. Kenrik Duru, MD, MSHSFrom Veterans Affairs Greater Los Angeles Health System, Veterans Affairs Health Services Research and Development Service Center for the Study of Healthcare Innovation, Implementation & Policy, and David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California;and David Geffen School of Medicine and Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, Los Angeles, California., and Carol M. Mangione, MD, MSPHFrom Veterans Affairs Greater Los Angeles Health System, Veterans Affairs Health Services Research and Development Service Center for the Study of Healthcare Innovation, Implementation & Policy, and David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California;and David Geffen School of Medicine and Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, Los Angeles, California.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-5136-2 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We respectfully disagree with Drs. Rodriguez-Gutierrez and Montori's statements that patients with prediabetes do not benefit from metformin and that a focus on "in-office" clinical approaches distracts from needed societal interventions to address the problem at a larger scale. The process by which diabetes develops is more complicated than a simple "on/off" switch at a particular glycemic threshold. There is a clear continuum of risk from normal glycemia to prediabetes to diabetes (1). Across this continuum, it is critical that providers and patients are aware of all available evidence-based approaches shown to lower the risk for progression.In ...References1. Tabák AG, Herder C, Rathmann W, Brunner EJ, Kivimäki M. Prediabetes: a high-risk state for diabetes development. Lancet. 2012;379:2279-90. [PMID: 22683128] doi:10.1016/S0140-6736(12)60283-9 CrossrefMedlineGoogle Scholar2. Diabetes Prevention Program Research Group.. Effects of withdrawal from metformin on the development of diabetes in the diabetes prevention program. Diabetes Care. 2003;26:977-80. [PMID: 12663559] CrossrefMedlineGoogle Scholar3. Diabetes Prevention Program Research Group.. Long-term safety, tolerability, and weight loss associated with metformin in the Diabetes Prevention Program Outcomes Study. Diabetes Care. 2012;35:731-7. [PMID: 22442396] doi:10.2337/dc11-1299 CrossrefMedlineGoogle Scholar4. Diabetes Prevention Program Research Group.. The 10-year cost-effectiveness of lifestyle intervention or metformin for diabetes prevention: an intent-to-treat analysis of the DPP/DPPOS. Diabetes Care. 2012;35:723-30. [PMID: 22442395] doi:10.2337/dc11-1468 CrossrefMedlineGoogle Scholar5. Diabetes Prevention Program Research Group.. HbA1c as a predictor of diabetes and as an outcome in the diabetes prevention program: a randomized clinical trial. Diabetes Care. 2015;38:51-8. [PMID: 25336746] doi:10.2337/dc14-0886 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Veterans Affairs Greater Los Angeles Health System, Veterans Affairs Health Services Research and Development Service Center for the Study of Healthcare Innovation, Implementation & Policy, and David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California;and David Geffen School of Medicine and Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, Los Angeles, California.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M14-1773. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMetformin Prescription for Insured Adults With Prediabetes From 2010 to 2012 Tannaz Moin , Jinnan Li , O. Kenrik Duru , Susan Ettner , Norman Turk , Abigail Keckhafer , Sam Ho , and Carol M. Mangione Metformin Prescription for Insured Adults With Prediabetes From 2010 to 2012 Rene Rodriguez-Gutierrez and Victor M. Montori Metformin Prescription for Insured Adults With Prediabetes From 2010 to 2012 Rene Rodriguez-Gutierrez and Victor M. Montori Metrics Cited ByReview of Metformin Use for Type 2 Diabetes PreventionIdentifying prevalence and risk factors for metformin non-persistence: a retrospective cohort study using an electronic health recordDiabetes Screening in US Women With a History of Gestational Diabetes, National Health and Nutrition Examination Survey, 2007–2012 15 September 2015Volume 163, Issue 6Page: 483KeywordsDiabetes preventionDisclosureHealth information technologyHemoglobinPrevention, policy, and public healthWeight loss ePublished: 15 September 2015 Issue Published: 15 September 2015 CopyrightCopyright © 2015 by American College of Physicians. 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