tbuckley/cabot-search huggingface dataset:
Percutaneous catheter modification of the atrioventricular node. A potential cure for atrioventricular nodal reentrant tachycardia.
Authors: L MEpstein, M MScheinman, J JLangberg, DChilson, H RGoldberg, J CGriffin
Journal: Circulation (1989)

Our purpose was to describe a technique of atrioventricular (AV) node modification for patients with drug refractory AV nodal reentrant tachycardia (AVNRT). Nine patients (mean age, 45 +/- 20; range, 14-82) with recurrent drug refractory AVNRT (n = 8) or sudden cardiac death thought to be precipitated by AVNRT (n = 1) underwent a percutaneous catheter procedure to modify AV nodal function. The area between the electrode recording the maximal His-bundle electrogram and the ostium of the coronary sinus was divided into three zones. Perinodal direct current shocks of 100-300 J were delivered to one (n = 2), two (n = 3), or three (n = 4) zones without complications. The procedure endpoints were modification of AV conduction (either first degree AV block or complete retrograde ventriculo-atrial [VA] block) and failure to induce AVNRT before or after isoproterenol and/or atropine administration. Six of nine patients (67%) have had no inducible or spontaneous AVNRT over a mean follow-up of 12.3 +/- 4.1 months (r...
Acute lung injury
Authors: Olaf van Ditzhuyzen, Aladin Nasimi, Michel Berthier, Denis Oriot, N. González Bravo, M. J. Ruíz López, E. Mora, A. Valdivielso, J. Casado Flores, B. P. Wagner, J. Pfenninger, D. C. G. Bachmann, Xian nan Chen, Ji chuan Wu, Rong Geng, Xi pei Zhang, A. P. Kolesnichenko, A. I. Gritsan, I. M. Kolesnichenko, I. V. Kuznetsova
Journal: Intensive Care Medicine (1996)
Prospective observations in patients with chronic bundle branch block and marked H-V prolongation.
Authors: R CDhingra, PDenes, DWu, C RWyndham, FAmat-y-Leon, W DTowne, K MRosen
Journal: Circulation (1976)

Eighteen of 388 patients with chronic bundle branch block, studied electrophysiologically and followed prospectively, had H-V intervals of 80 msec or greater. Five patients were functional class I, five class II, seven class III, and one class IV. Follow-up ranged from 103 to 1919 days (mean 711 +/- 118). Three patients needed permanent pacing for the following indications: sino-atrial block, sinus bradycardia post-cardiac surgery, and 2 degrees block distal to the His bundle. Six patients died, three suddenly, and three nonsudden. The five initially asymptomatic patients are alive and without pacemakers (mean follow-up 732 +/- 139 days). Although marked H-V prolongation was associated with high morbidity and mortality in this small series, this was only in patients with symptomatic heart disease. Asymptomatic patients (five patients) had a benign clinical course. Prophylactic pacing would probably not modify clinical course in the former group, and is probably not indicated in the latter group. Longer fo...
Haemoptysis: a frequent diagnostic challenge
Authors: Philippe Bonniaud, Marjolaine Georges, Caroline Abdulmalak, Guillaume Beltramo, Jonathan Cottenet, Philippe Camus, Catherine Quantin
Journal: European Respiratory Journal (2015)

We appreciate and agree with the comments of M. Mondoni and colleagues, that the results of the ongoing prospective Italian multicentre trial ([www.ClinicalTrial.gov][1] identifier [NCT02045394][2]) will be of considerable interest for the management of haemoptysis, a frequent and severe symptom, especially since there is no clear consensus concerning aetiology and treatment. Interestingly, beyond determining the prevalence of diseases that may present with haemoptysis, their epidemiological results will be analysed according to the severity of the symptom. More importantly, their trial will hopefully make it possible to analyse the sensitivity and specificity of complementary tests, such as chest radiography, chest computed tomography (CT) and bronchoscopy alone and in combination in the diagnosis of different causes of haemoptysis. Haemoptysis associated with high 3-year in-hospital mortality in large retrospective cohort study in France <http://ow.ly/UeyV9> [1]: http://www.ClinicalTrial.gov [2]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT02045394&atom=%2Ferj%2F47%2F1%2F350.atom
Radionuclide measurement of left ventricular volume: comparison of geometric and counts-based methods.
Authors: B MMassie, B LKramer, E WGertz, S GHenderson
Journal: Circulation (1982)

Radionuclide measurements of left ventricular volume were determined in 20 patients by geometric and nongeometric, counts-based techniques using data from first-pass and equilibrium blood pool scintigraphy. Two geometric analytic approaches were used: directly measured long and short axes and the area-length method. Each approach was applied to the single-plane right anterior oblique images obtained by the first-pass technique and to biplane data, using the right anterior oblique first-pass and left anterior oblique blood pool data together. For the nongeometric determinations, background-corrected left ventricular counts were related to blood counts. This ratio was converted to volume by means of a linear regression relationship with angiographic volumes. All methods yielded high correlation coefficients (r greater than or equal to 0.93), but the standard errors of the estimates for the geometric techniques were high, and therefore the 95% confidence limits were wide. The use of biplane data improved the...
Seeding of intravascular stents with genetically engineered endothelial cells.
Authors: D ADichek, R FNeville, J AZwiebel, S MFreeman, M BLeon, W FAnderson
Journal: Circulation (1989)

The use of intravascular stents may be limited by both local thrombosis and restenosis due to intimal proliferation. In an effort to provide solutions to these problems, we seeded stents with genetically engineered endothelial cells in vitro. Using retroviral-mediated gene transfer, we inserted the gene for either bacterial beta-galactosidase or human tissue-type plasminogen activator (t-PA) into cultured sheep endothelial cells. The endothelial cells were seeded onto stainless steel stents and grown until the stents were covered. Expression of intracellular beta-galactosidase and high level secretion of t-PA were demonstrated both before and after the transduced cells were seeded onto the stents. Eight stents were expanded by in vitro balloon inflation, with observation of the seeded endothelial layer both prior to and after expansion. Most of the endothelial cells remained on the stents after balloon inflation. We conclude that intravascular stents can be coated with a layer of genetically engineered en...
Activated CD4+ T cells and CD14hiCD16+ monocytes correlate with antibody response following influenza virus infection in humans
Authors: Sook-San Wong, Christine M. Oshansky, Xi-Zhi J. Guo, Jacqui Ralston, Timothy Wood, Gary E. Reynolds, Ruth Seeds, Lauren Jelley, Ben Waite, Trushar Jeevan, Mark Zanin, Marc-Alain Widdowson, Q. Sue Huang, Paul G. Thomas, Richard J. Webby, Nikki Turner, Michael Baker, Cameron Grant, Colin McArthur, Sally Roberts, Adrian Trenholmes, Conroy Wong, Susan Taylor, Mark Thompson, Diane Gross, Jazmin Duque, Kathryn Haven, Debbie Aley, Pamela Muponisi, Bhamita Chand, Yan Chen, Laurel Plewes, Frann Sawtell, Shirley Lawrence, Reniza Cogcoy, Jo Smith, Franie Gravidez, Mandy Ma, Shona Chamberlin, Kirstin Davey, Tania Knowles, Jo-Ann McLeish, Angela Todd, Judy Bocacao, Wendy Gunn, Pamela Kawakami, Susan Walker, Robyn Madge, Nicole Moore, Fahimeh Rahnama, Helen Qiao, Fifi Tse, Mahtab Zibaei, Tirzah Korrapadu, Louise Optland, Cecilia Dela Cruz
Journal: Cell Reports Medicine (2021)

The failure to mount an antibody response following viral infection or seroconversion failure is a largely underappreciated and poorly understood phenomenon. Here, we identified immunologic markers associated with robust antibody responses after influenza virus infection in two independent human cohorts, SHIVERS and FLU09, based in Auckland, New Zealand and Memphis, Tennessee, USA, respectively. In the SHIVERS cohort, seroconversion significantly associates with (1) hospitalization, (2) greater numbers of proliferating, activated CD4+ T cells, but not CD8+ T cells, in the periphery during the acute phase of illness, and (3) fewer inflammatory monocytes (CD14hiCD16+) by convalescence. In the FLU09 cohort, fewer CD14hiCD16+ monocytes during early illness in the nasal mucosa were also associated with the generation of influenza-specific mucosal immunoglobulin A (IgA) and IgG antibodies. Our study demonstrates that seroconversion failure after infection is a definable immunological phenomenon, associated with quantifiable cellular markers that can be used to improve diagnostics, vaccine efficacy, and epidemiologic efforts.
Long-lasting effect of oral molsydomine on exercise performance: a new antianginal agent.
Authors: ATakeshita, MNakamura, TTajimi, HMatsuguchi, AKuroiwa
Journal: Circulation (1977)

This study examines whether the beneficial effects of molsydomine, a recently introduced antianginal agent, on exercise performance of patients with angina pectoris are long lasting. The hemodynamic effects are known to persist for several hours. The effects of molsydomine on the duration of exercise and the time to the onset of ST depression were compared to those of placebo during two hours after oral administration. Molsydomine prolonged the duration of exercise in all eight patients (average 2.8 min, P less than 0.001) and delayed the onset of ST depression (average 2.2 min, P less than 0.001), while the placebo failed to alter these measurements. The increment of the duration of exercise produced by 2 mg of molsydomine in two hours following oral administration was comparable to the increment produced in a few minutes after 0.3 mg of nitroglycerin given sublingually. The results indicate that molsydomine offers prophylasis for angina pectoris that lasts at least two hours after oral administration.
Preoperative secundum atrial septal defect with coexisting sinus node and atrioventricular node dysfunction.
Authors: E BClark, J DKugler
Journal: Circulation (1982)

Sinus node dysfunction in patients after repair of the secundum atrial septal defect has been ascribed to surgical damage. We studied 15 consecutive patients with secundum atrial septal defect before operative intervention. Noninvasive testing included 34-hour electrocardiographic monitoring and a standard 13-lead ECG. Intracardiac electrophysiologic techniques included corrected sinus node recovery time, sinoatrial conduction time, His bundle recording to measure AH and HV intervals, the atrial pacing rate at which atrioventricular node Wenckebach occurred, and atrioventricular nodal refractory period. The ECG revealed an ectopic atrial rhythm in two patients. Intracardiac electrophysiology showed an abnormal corrected sinus node recovery time (range -40 to 800 msec) in 10 patients. Five patients had evidence of atrioventricular nodal dysfunction with prolonged AH interval or abnormal atrial pacing rate at which atrioventricular Wenckebach occurred. These data indicate that sinus node dysfunction or atri...
Physiologic improvement following coronary artery bypass surgery.
Authors: D WMiller, R ABruce, H TDodge
Journal: Circulation (1978)

In this study the effects of coronary artery bypass surgery on ventricular function were evaluated at rest by quantitative analysis of segmental wall motion on cineventriculography, and during maximal treadmill exercise by measurement of serial cardiac outputs (Fick method) with the use of indwelling pulmonary artery and radial artery catheters. The patient had single vessel coronary disease and exertional angina. Following placement of a bypass graft to the proximally occluded left anterior descenting coronary artery, and despite the presence of arterial hypoxemia secondary to interstitial pulmonary fibrosis, a striking increase in maximal cardiac output occurred, mediated by a rise in both maximal heart rate and stroke volume. In this patient, resting ventricular volumes and ejection fraction were normal both before and after surgery, but preoperative abnormalities in extent of segmental wall motion, identified quantitatively, were restored to normal after bypass grafting. These investigations indicate ...
Toxic effects of silver-silver chloride electrodes on vascular smooth muscle.
Authors: W FJackson, B RDuling
Journal: Circulation Research (1983)

We found that silver, either as silver metal or silver chloride, exerted toxic effects on the smooth muscle of isolated cannulated hamster cheek pouch arterioles. Silver initially stimulated the smooth muscle, producing a marked vasoconstriction. The vessels then dilated back to control diameters. Once the arterioles began to dilate, they became refractory to norepinephrine or potassium stimulation. We caution the use of silver in the presence of smooth muscle, especially when tissue mass is small or free protein concentration is low.
DIDS-sensitive pHi regulation in single rat cardiac myocytes in nominally HCO3-free conditions.
Authors: M LWu, M LTsai, Y ZTseng
Journal: Circulation Research (1994)

The fluorescent dye 2',7'-bis(carboxyethyl)-5,6-carboxyfluorescein (BCECF) was used to measure pHi in the spontaneously hypertensive rat (SHR) and in normal rat cardiac myocytes under nominally HCO3-free (20 mmol/L HEPES-buffered) conditions. When only the Na-H exchanger was blocked, the intrinsic buffering power (beta i) in SHR myocytes was significantly higher than when both the Na-H exchanger and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS)-sensitive pHi regulators (the Na-HCO3 cotransporter and the Cl-HCO3 exchanger) were blocked. Similar low values for beta i were also found for normal rat myocytes in Na(+)-free conditions. In Cl(-)-free solution under nominally HCO3-free conditions, in both normal and SHR myocytes, the pHi slowly alkalinized (by 0.16 +/- 0.02 and 0.11 +/- 0.02 pH units, respectively); this alkalinization was also DIDS sensitive. The reacidification during NH4+ perfusion was inhibited 30.2 +/- 7.4% by DIDS. In addition, in the nominal absence of HCO3-, 100 mumol/L ATP ac...
An enzyme histochemical study of human sinus node, coronary sinus, and mitral valve muscle.
Authors: CThéry, IKrivosic, PAsseman, A EMeijer
Journal: Circulation (1985)

An enzyme histochemical study of the sinoatrial node, the coronary sinus, and the atrial muscle extending into the anterior mitral valve was performed on human hearts. Investigation of the activity and localization of the structurally bound enzymes was performed by conventional histochemical techniques. Determination of the activity of nonstructurally or weakly structurally bound enzymes was performed by histochemical techniques in which leakage of enzymes during the incubation period was reduced by the application of semipermeable membranes. The sinoatrial node is characterized by a high degree of anaerobic enzyme capacity and a relatively low degree of aerobic enzyme capacity. The discriminatory nature of these reactions allows examination of the structure of the sinoatrial node and its approaches. The presence of transitional cells was confirmed; isolated clusters of nodal cells were found in the atrial myocardium around the sinoatrial node, but no evidence of specialized tissue forming the beginning o...
Oral Anticoagulant Drugs
Authors: F J vd Meer, F R Rosendaal, S C Cannegieter, E Briët
Journal: New England Journal of Medicine (1992)

centration found in the left atrium. 7 Were reinnervation to spread from preexisting ganglia within the donor heart, one would anticipatc that nerve proliferation would emanate from the right atrium and other small sites where ganglia are concentrated.The notion that ehest pain during myocardial ischemia could originale from the atrial remnant or other ehest Organs is difficult to accept.If the pain came from the recipient's tissue, then the occurrence of pain should have had no relation to markers of donor reinnervation and no correlation with ischemic cardiac events (the opposite of our observations).We appreciate the comments of Dr. Uretsky.His experience reinforces the importance of sensory reinnervation after cardiac transplantation.
EUS-Guided Gallbladder Drainage Using Lumen-Apposing Metal Stent As Rescue Treatment For Malignant Distal Biliary Obstruction: A Large Multicenter Experience
Authors: C Binda, A Anderloni, A Fugazza, A Amato, G de Nucci, A Redaelli, R Di Mitri, L Cugia, V Pollino, R Macchiarelli, B Mangiavillano, E Forti, ML Brancaccio, R Badas, M Maida, E Sinagra, A Repici, C Fabbri, I Tarantino
Journal: Endoscopy (2021)

Aims Evaluation of safety and effectiveness of endoscopic ultrasound-guided gallbladder (EUS-GBD) with lumen apposing metal stent (LAMS) as a rescue treatment for the relief of jaundice in patients with malignant distal biliary obstruction (MDBO) and failure both of endoscopic retrograde cholangiopancreatography (ERCP) and EUS-guided choledochoduodenostomy (EUS-CDS).
Serial echocardiographic assessment of left ventricular geometry and function after large myocardial infarction in the rat.
Authors: S ELitwin, S EKatz, J PMorgan, P SDouglas
Journal: Circulation (1994)

BACKGROUNDThe development of heart failure after acute myocardial infarction (MI) may be related to alterations of left ventricular (LV) structure and function. Pathological LV remodeling may exacerbate systolic and diastolic dysfunction because increased cavity dimensions tend to increase LV wall stress. Unfortunately, many complicating factors have made it difficult to clearly define the time course of LV remodeling after myocardial infarction in patients, and the contribution of structural changes to altered function has not been fully explored.METHODS AND RESULTSTo determine the type, magnitude, and time course of changes in LV geometry and function, we performed transthoracic Doppler echocardiographic examinations in rats before and 1 and 6 weeks after transmural MI induced by coronary ligation. LV internal diastolic dimension was greater in infarcted than in sham-operated rats at 1 and 6 weeks after MI (9.4 +/- 0.6 versus 8.0 +/- 0.5 and 10.1 +/- 0.9 versus 8.5 +/- 0.9 mm, respectively; P < .05 comp...
Family History of Gastric Cancer and the Risk of Progression of Gastric Premalignant Conditions: A Prospective, 10-Year Endoscopic Follow-up Study
Authors: M Garrido, JR Viscaíno, M Dinis-Ribeiro, F Carneiro, I Pedroto, R Marcos-Pinto
Journal: Endoscopy (2021)

Aims We aimed to evaluate the progression of gastric precancerous conditions and the incidence of gastric dysplasia/neoplasia in first-degree relatives of gastric cancer patients.
Severe Sepsis and Septic Shock
Authors: Job Calis, Job van Woensel, Joris Lemson
Journal: New England Journal of Medicine (2013)

To the Editor: We would like to address two potentially confusing issues concerning venous oxygen saturation (Svo(2)) as presented in Table 1 of the review by Angus and van der Poll (Aug. 29 issue).(1) First, Table 1 suggests that Svo(2) is raised in sepsis, severe sepsis, and septic shock. Depending on the timing of patient presentation and the type of sepsis and septic shock, Svo(2) may indeed be elevated as a result of microcirculatory shunting or mitochondrial dysfunction. However, in septic shock, Svo(2) can be depressed, reflecting an increase in the extraction of oxygen due
Anomalous left coronary artery from pulmonary artery. An eight year angiographic follow-up after saphenous vein bypass graft.
Authors: B RChaitman, M GBourassa, JLespérance, PGrondin
Journal: Circulation (1975)

We have presented a 7-week and 8-year postoperative angiographic follow-up of a 36-year-old man who had an anomalous left coronary artery arising from the pulmonary artery and who had an aortocornary bypass graft to the left anterior descending artery. The late study showed 1) a large, well functioning patent graft, 2) lack of significant postoperative change in the size of the right coronary artery and 3) new collateral vessels between the distal left anterior descending and left circumflex coronary arteries and persistence of collateral vessels between the distal right and left circulflex coronary arteries. This report is the longest known angiographic follow-up of a patient with this anomaly who has been treated with bypass surgery.
Concealed conduction in accessory atrioventricular pathways: an important determinant of the expression of arrhythmias in patients with Wolff-Parkinson-White syndrome.
Authors: G JKlein, RYee, A DSharma
Journal: Circulation (1984)

Concealed conduction into accessory atrioventricular pathways has been postulated to explain variability of R-R intervals during atrial fibrillation in patients with Wolff-Parkinson-White syndrome. We examined the occurrence of concealed conduction into atrioventricular pathways using extrastimulus techniques in 26 consecutive patients undergoing electrophysiologic studies for the Wolff-Parkinson-White syndrome. Anterograde pathway concealment was demonstrated (10 patients) by introducing a second atrial extrastimulus (A3) after block in the accessory pathway occurred following the first extrastimulus (A2). The apparent effective refractory period (ERP) of the atrioventricular pathway with A3 (after A2 blocked in the pathway), or ERPB, was always greater than the ERP of the atrioventricular pathway (505 +/- 100 vs 323 +/- 105 msec, mean +/- SD; p less than .001), a finding explained by concealment into the pathway by the blocked A2. A measure of the apparent prolongation of refractoriness due to anterogra...
Pressure-volume relation around zero transmural pressure in excised cross-circulated dog left ventricle.
Authors: HSuga, YYasumura, TNozawa, SFutaki, NTanaka
Journal: Circulation Research (1988)

Left ventricular (LV) pressure-volume (PV) relations of quasi-isobaric contractions around zero transmural pressure were studied with a new volumetric method. Left ventricles of isolated cross-circulated dog hearts were connected to a large air tank through the mitral annulus. The volume of the air space was changed with a volume servo pump to oscillate the transmural pressure (P) around zero. Instantaneous LV volume (V) was computed from P by Boyle's law (P.V = constant) to draw the PV trajectories of the isobaric contractions. The end-systolic PV relation (ESPVR) and end-diastolic PV relation (EDPVR) curves intercepted the volume axis at two different volumes (Vo and Vu, respectively). The slopes of both ESPVR and EDPVR curves as well as Vo and Vu were variably influenced by positive and negative inotropic states, heart rate changes, arrhythmias, ischemia, and rigor. In control before any interventions, LV stroke and suction volume (delta V = Vu - Vo) at zero P was 7.5 +/- 2.5 (SD) ml/100 g left ventric...
Angled views in cineangiocardiography of congenital heart disease.
Authors: K EFellows, J FKeane, M DFreed
Journal: Circulation (1977)

Simple and compound sagittally angled views of the heart obtained cineangiocardiographically with a parallelographic U-arm device were evaluated clinically in 132 patients with congenital heart disease. The principle advantage of the apparatus was the case with which axial and oblique projections were obtained without repositioning of the patient, although rotation and angulation of the image intensifier-X-ray tube unit resulted in some increase in scattered radiation. Certain angled views, particularly the 40 degree cranial and the compound 25 degrees cranial/70 degrees left oblique projections, were better than standard frontal and lateral views for visualization of pulmonary arteries in the mediastinum, in ventricular septal defects and anomalies of the left ventricular outflow tract.