tbuckley/cabot-search huggingface dataset:
Use of a cholangioscopy-guided retrieval snare for the macrobiopsy of a choledochal polyp
Authors: Claudio Zulli, Mariano Sica, Michele Fusco, Carmela Abbatiello, Antonio D’Antonio, Attilio Maurano, Mario Gagliardi
Journal: Endoscopy (2022)

A 65-year-old man with a 1-year history of recurrent episodes of right upper quadrant colicky pain presented with this complaint to our outpatient clinic. The patient’s past medical history included hypertension. He underwent a transabdominal ultrasound scan, which showed a hypoechoic nodular lesion of 12 mm in the proximal common bile duct (CBD), without evidence of distension of the intrahepatic biliary ducts. Therefore, an endoscopic ultrasound (EUS) was scheduled and performed. The EUS examination confirmed the presence of a hypoechoic nodular lesion of 13 × 12 mm in the proximal CBD, along with a slight biliary stricture. Given the suspicion of cholangiocarcinoma, endoscopic retrograde cholangiopancreatography (ERCP) was indicated. After informed consent for the procedure and appropriate sedation had been given, ERCP was performed.
index to advertisers
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Critères de L'Aptitude au Vol en Avion.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in the Byline
Journal: JAMA Network Open (2022)

Marie-Jeanne Buscot, PhD; Ronil V. Chandra, MBBS; Julian Maingard, MBBS; Linda Nichols, MSc; Leigh Blizzard, PhD; Christine Stirling, PhD; Karen Smith, PhD; Leon Lai, MBBS, PhD; Hamed Asadi, MBBS; Jens Froelich, MBBS; Mathew J. Reeves, PhD; Nova Thani, MBBS; Amanda Thrift, BSc (Hons), PhD, PGDipBiostat; Seana Gall, PhD
The Impact of Sex and Gender on Stroke
Authors: Kathryn M. Rexrode, Tracy E. Madsen, Amy Y.X. Yu, Cheryl Carcel, Judith H. Lichtman, Eliza C. Miller
Journal: Circulation Research (2022)

Women face a disproportionate burden of stroke mortality and disability. Biologic sex and sociocultural gender both contribute to differences in stroke risk factors, assessment, treatment, and outcomes. There are substantial differences in the strength of association of stroke risk factors, as well as female-specific risk factors. Moreover, there are differences in presentation, response to treatment, and stroke outcomes in women. This review outlines current knowledge of impact of sex and gender on stroke, as well as delineates research gaps and areas for future inquiry.
Can lung cancer be cured by irradiation alone?
Authors: J. Smart
Journal: JAMA (1966)

The published results of cases treated by irradiation alone are not encouraging. Hilton in 1955<sup>15</sup>reported eight patients out of 203 who survived five years following radiotherapy. Paterson et al in 1950<sup>16</sup>from the Christie Hospital, Manchester, England, reported seven patients out of 254 who survived five years. Dobbie in 1944<sup>17</sup>and Shorvon in 1947<sup>18</sup>reported a 2% survival rate for five years. However, Brooks et al in 1951<sup>19</sup>described four patients treated by irradiation only, who came to necropsy with no evidence of growth in the lung. These patients all had inoperable carcinomas and indicate that certain primary carcinomas can be treated and cured by irradiation alone. It must be remembered that the original figures quoted are patients treated by radiotherapy who were considered unsuitable for surgery for one reason or another. Operable patients treated at the Bromptom and the London Chest hospitals showed
Management of Diabetes in Correctional Institutions
Journal: Diabetes Care (1991)

Management of Diabetes in Correctional InstitutionsT he American Diabetes Association is committed to quality medical care for all people with diabetes.Individuals with diabetes who are in correctional institutions should receive medical care that is equivalent to that delivered to other people with diabetes.Health-care providers and criminal justice officials must understand the complexities of diabetes management.Correctional institutions should provide adequate treatment for inmates with diabetes.With timely and appropriate treatment, the potentially life-threatening acute complications of diabetes can be minimized.Therefore, it is essential that the person with diabetes
Antibody response against SARS-CoV-2 Delta and Omicron variants after third-dose BNT162b2 vaccination in allo-HCT recipients
Authors: Lorenzo Canti, Kevin K. Ariën, Isabelle Desombere, Stéphanie Humblet-Baron, Pieter Pannus, Leo Heyndrickx, Aurélie Henry, Sophie Servais, Evelyne Willems, Grégory Ehx, Stanislas Goriely, Laurence Seidel, Johan Michiels, Betty Willems, Maria E. Goossens, Yves Beguin, Arnaud Marchant, Frédéric Baron
Journal: Cancer Cell (2022)
Abstract 17235: Attenuation of NPR-C Binding With Muscle-Derived Musclin is Related to Reduced Cardiovascular Disease Risks by Aerobic Exercise Training in Type 2 Diabetic Rats
Authors: Yuta Toyama, Natsuki Hasegawa, Naoki Horii, Kenichiro Inoue, Keiko Iemitsu, Shumpei Fujie, Masataka Uchida, Motoyuki Iemitsu
Journal: Circulation (2018)

Introduction: Aerobic exercise training (AT) in type 2 diabetic patients reduces cardiovascular disease (CVD) risks, such as an impairment of NO-derived vasodilation mediated by obese and hyperinsulinemia. Musclin is a muscle-derived myokine and binds to natriuretic peptide receptor-C (NPR-C). Elevation of circulating musclin level deteriorates of insulin resistance. Furthermore, musclin-induced vasocontraction mediated by NPR-C leads to increase in blood pressures. However, the effect of AT on muscle-derived musclin secretion in type 2 diabetes remains unclear. Hypothesis: This study aimed to clarify whether AT-induced attenuations of muscle-derived musclin secretion and arterial NPR-C expression levels are related to reduction of CVD risks in type 2 diabetes rats. Methods: Twenty 20-week-old male type 2 diabetic (OLETF) rats were randomly divided into two groups; 8-week sedentary control and aerobic exercise training (treadmill running for 60min at 25m/min, 5days/week) (n=7 each group) and seven male LETO rats used as healthy sedentary control. After 8 weeks, we measured carotid-femoral pulse wave velocity (cfPWV, an index of arterial stiffness), QUICKI (an index of insulin sensitivity), plasma and muscle musclin levels and GLUT4 translocation levels, arterial NPR-C protein expression. Results: In sedentary diabetic rats, cfPWV, serum insulin and muscle musclin levels, and arterial NPR-C protein expression increased, and QUICKI decreased as compared to healthy sedentary rats (each p&lt;0.05). However, no significant circulating musclin level between sedentary and exercised diabetic rats was observed. In contrast, aerobic exercise training in the diabetic rats induced elevation of QUICKI and reduction of cfPWV, serum insulin, muscle musclin, and arterial NPR-C levels (each p&lt;0.05). NPR-C protein level was positively correlated with cfPWV (r=0.43, p=0.09). Additionally, muscle musclin levels was significantly negatively correlated with muscle GLUT4 translocation (r=-0.78, p&lt;0.01) and QUICKI (r=-0.82, p&lt;0.01). Conclusions: These results suggest that attenuation of arterial NPR-C expression and muscle-derived musclin secretion is related to reductions of arterial stiffness and hyperinsulinemia by AT in type 2 diabetic rats.
Societal extinction of species
Authors: Ivan Jarić, Uri Roll, Marino Bonaiuto, Barry W. Brook, Franck Courchamp, Josh A. Firth, Kevin J. Gaston, Tina Heger, Jonathan M. Jeschke, Richard J. Ladle, Yves Meinard, David L. Roberts, Kate Sherren, Masashi Soga, Andrea Soriano-Redondo, Diogo Veríssimo, Ricardo A. Correia
Journal: Trends in Ecology & Evolution (2022)
Textbook outcome among patients undergoing enhanced recovery after liver transplantation stratified by risk. A single-center retrospective observational cohort study
Authors: Paola Melgar, Gonzalo P. Rodríguez-Laiz, Núria Lluís, Cándido Alcázar-López, Mariano Franco-Campello, Celia Villodre, Sonia Pascual, María Rodríguez-Soler, Pau Bellot, Cayetano Miralles, Miguel Perdiguero, María Díaz, Patricio Mas-Serrano, Pedro Zapater, José Manuel Ramia, Félix Lluís
Journal: International Journal of Surgery (2022)
Highlights From the International Stroke Conference 2022—Thrombectomy and Alteplase, Access to Stroke Centers, and Warfarin vs Direct Oral Anticoagulants
Authors: Melissa Suran
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 17223: Castle of Stone or Straw, Radiofrequency Ablation of Atrial Fibrillation in Heart Failure?
Authors: Brian D McCauley, Esseim Sharma, John Dudley, Antony Chu
Journal: Circulation (2018)

Introduction: Based on the data from CASTLE-AF trial, in patient with Atrial Fibrillation (AF) and heart failure (HF) catheter ablation may offer a significant reduction in both death, and hospitalization, while promoting maintenance of sinus rhythm as well as improvement in left ventricular ejection fraction (LVEF). This multi-center randomized trial is hailed as a paradigm shifting study in catheter ablation, however it is not without fault. One of the critiques of the CASTLE-AF trial was the high frequency of crossover between the treatment arms. To help sort out this potential source of confounding, we performed a systematic meta-analysis of prospective trials for catheter ablation in AF in patients with Class II through IV heart failure. Hypothesis: The reduction in death, and hospitalization, as well as the maintenance in sinus rhythm and improvement in LVEF seen CASTLE-AF trial are support by other similarly designed AF ablation trials. Methods: Using the inclusion/exclusion criteria from the CASTLE-AF trial, we performed a systematic meta-analysis of 28 published studies. Randomized and non-randomized observational studies comparing the impact of catheter ablation of AF in HF. Studies were identified using the Cochrane Library, EMBASE, and PubMed. Results: A total of 29 studies were identified (n =2,339). Mean follow-up was 25 (95% confidence interval, 18-40) months. Efficacy in maintaining sinus rhythm at follow-up end was 60% (43%-76%). Left ventricular ejection fraction improved significantly during follow-up by 15% (P&lt;0.001). Conclusions: Following our meta-analysis, we found data to support the findings of improved LVEF and maintenance of sinus rhythm reported in the CASTLE-AF trial. However, due to differences in study design, we were unable to further validate the reduction in both hospitalization and death seen in CASTLE-AF. We recommend future prospective trials be conducted without cross over to further explore this topic.
Nursing Institutions
Authors: F. T. Paul
Journal: BMJ (1880)

conditions of life, I advise the patient to wash his neck and chest in the morning with cold water, not to wrap himself up too much in warm neckties, shawls, etc., but to wear flannel underclothing; to take his usual food, with the exception of strong spices, mixed pickles, etc.; to drink claret in moderate quantity, but to avoid heavy beers, champagne, brandy, whiskey, etc., and never to drink spirits in excess, because this of course augments the congestion.I do not order the patient, if he be accustomed to strong smoking, to give this up all at once, because I find that the sudden leaving oft smoking generally brings about dys- pepsia, loss of appetite, constipation, and other disagreeable symptoms;
Meningococcal meningitis
Authors: A S Sohal, V R Rao
Journal: BMJ (1988)

It is no longer justifiable for one physician to spend twice as much money as another on treating patients with similar diseases,"3 yet it is almost embarrassing to report that only the private sector seems to be using well researched, humane, and acceptable techniques which reduce the duration of opiate withdrawal from the usual two to three weeks to two to three days or less.6
Replies to commentaries on the generalizability crisis
Authors: Tal Yarkoni
Journal: Behavioral and Brain Sciences (2022)

Abstract The 38 commentaries on the target article span a broad range of disciplines and perspectives. I have organized my response to the commentaries around three broad questions: First, how serious are the problems discussed in the target article? Second, are there are other, potentially more productive, ways to think about the issues that the target article framed in terms of generalizability? And third, what, if anything, should we collectively do about these problems?
Outcomes of an advanced practice nurse (APN)-led cancer genetics service.
Authors: Lisa Aiello, Jeffrey Petersen, Julie Ann Lynch, Lori Hoffman-Hogg, Nevena Damjanov, Kyle William Robinson, Yu-Ning Wong, Darshana Jhala, Kara Noelle Maxwell
Journal: Journal of Clinical Oncology (2022)

71 Background: In oncology practice, there are increasing numbers of patients for whom genetic testing is recommended by the National Cancer Care Network (NCCN), including all metastatic and high-risk localized prostate cancer patients. However, there is a critical shortage of genetics services providers. Acuity for these consults can be high, particularly in the context of a treatment related decision. We hypothesized that nurses, particularly advanced practice nurses (APNs), can provide a workforce within VA that can address genetic testing and genetic care needs of prostate cancer patients. Methods: We initiated a cancer genetics service staffed with an advanced practice nurse (APN) geneticist and evaluated the success of the program at a large urban, academic-affiliated Veteran’s Affairs Medical Center (VAMC). Results: In the one year prior to the initiation of the APN geneticist-run program (10/1/2019-9/30/2020), 61 unaffected patients with a family history of cancer and 85 patients with cancer (36 with prostate cancer) were referred to a VA centralized telegenetics service. An average of seven cancer patients (average three with prostate cancer) were referred to VA telegenetics per month. Genetic testing was completed in eleven (18%) of unaffected patients and 21 (25%) of cancer patients. Five (13%) of tested patients were found to have a pathogenic or likely pathogenic mutation or variant of uncertain significance (VUS). In the eight months after initiation of the APN geneticist-run consult service (10/1/2020 - 5/30/2021), 39 unaffected patients with a family history of cancer and 90 patients with cancer (38 with prostate cancer) were referred. An average of 11 cancer patients (average five with prostate cancer) per month were referred. This represents a 57% increase in all cancer patient and a 67% increase in prostate cancer patient referrals. For those patients referred to the APN geneticist-run consult service, genetic testing was completed in three (7%) of unaffected patients and 30 (33%) of cancer patients (including 15 prostate cancer patients). The genetic testing rate therefore improved from 1.7 oncology patients per month to 3.9 oncology patients per month, an 130% increase in genetic testing. For prostate cancer patients, the genetic testing rate improved from 0.8 to 1.9 patients tested per month, representing a 137% increase. Comparison of genetic testing outcomes at one year will be included in the final presentation. Conclusions: Inclusion of an APN geneticist-run consult service embedded in oncology clinics will likely improve access to genetics services and genetic testing rates in cancer patients.
Transient receptor potential vanilloid 1 plays a major role in low temperature–mediated skin barrier dysfunction
Authors: Byung Eui Kim, Jessica Hui-Beckman, Taras Lyubchenko, Clifton F. Hall, Sahand Fallahi, Amelia Brull, Elena Goleva, Donald Y.M. Leung
Journal: Journal of Allergy and Clinical Immunology (2022)
Tumoral calcinosis.
Authors: P. Sames
Journal: BMJ (1969)

medicine or surgery, and there is far more to theatre work than the actual operation.Can there be real efficiency without understanding, or understanding without a firm basis of known facts on which to build ?There must not be any gaps in the theatreworker's understanding of the basic prin- ciples of his craft nor in his ability to apply his knowledge.While we rely on the traditional in-service training now given to both nurses and technicians, such gaps are inevitable and can be dangerous.We believe that the responsibility for training theatre staff should be relinquished by individual hos- pitals, since the shortage of staff and pressure of work prevailing in most theatres militate against a first-class in-service training.
Acute Intussusception in Childhood
Authors: B. Morrison, D. Court
Journal: BMJ (1948)

general anatomy resembles pernicious anaemia, and there is a failure in varying degree to respond to specific anti- pernicious-anaemia therapy, the course being sometimes prolonged with the help of blood transfusions (Wilkinson and Israels, 1935, 1936).The following is the report of a patient with achrestic anaemia under the care of Dr. Stock.A housewife aged 26 complained of weakness, lack of energy, dyspnoea, palpitation, and increasing pallor.There were no gastro-intestinal symptoms, glossitis, or involvement of the central nervous system or peripheral nerves.No haemolysis was to be found.Gastric secretion contained normal amounts of hydrochloric acid.Sternal puncture on May 7, 1947, showed an active cellular marrow with 42.5% megaloblasts, while a few days later it contained 8% megaloblasts and 34% normoblasts and was still very active and cellular.A blood count on Ap&g 21 showed: R.
Chloroma
Authors: R. E. Horsfall
Journal: BMJ (1938)

BRITISHdied nine da\7s later.There was a foul osteomrnelitis of the left side of the jaw, pus from wvhich extended into the cellular tissues of the neck, but no mediastinitis was found.The lower lobes of both lungs were almost completely solid from a very large number of small abscesses.In the left upper lobe there was a broken-down abscess three-quarters of an inch in diameter, which may have been older than the others.The pus in all the abscesses was very foul.No tooth fragment could be found though a careful search was made, and this would have been a relatively easy case in which to discover it had it been present.The heart and other organs were normal.It appeared clear from the distribution that these abscesses were the result of inhaled septic matter.It is possible that the basal abscesses were secondary to the one in the left upper lobe, but the history does not support that suggestion.It is difficult to imagine an anaesthetic less likely to favour inhalation of septic matter than a brief ethyl chloride spray.The boy was reasonably well for several days, and then his mouth began filling up with pus, which was very offensive, but which he could not be persuaded to spit out.He almost continually had his mouth full of it, and so there must have been many occasions on which it entered his trachea.The dentist and the anaesthetic were naturally exonerated in this case.Case 2.-On May 1 I made a necropsy on the body of an elderly woman.A tooth fragment was found in the middle of the right lower lobe of the lung.There was no surround- ing abscess, but a diffuse acute pulmonary oedema was present, with blood-stained froth in the trachea and bronchi.
Headache.
Authors: M Jamieson
Journal: BMJ (1984)

Headache, although a near universal experience, is a relatively uncommon reason for consultation in general practice.The consultation rate for migraine, for example, is said to be 12 per 1000 consultations, and it is estimated that the average general practitioner will see 28 patients on account of headache yearly.'Most headache is of the migrainous or tension type.Fry estimates that less than 1% of headaches presenting to a general practitioner reflect "major intracranial disease."2Despite its predominantly benign nature, headache may, however, be the presenting feature of potentially serious conditions such as cerebral tumour, meningitis, giant cell arteritis, and glaucoma.Cervical spondylosis, chronic sinusitis, and refractory errors probably cause headache less often than is commonly supposed. ClassificationA useful classification is that of the National Institute of Neuro- logical Disease and Blindness 1962.3This is summarised below.(1) Vascular headache of migraine type:A Classic migraine, B Common migraine, C Cluster headache, D Hemiplegic and ophthalmoplegic migraine, E "Lower half" headache.(2) Muscle contraction headache.(3) Combined headache: vascular and muscle contraction.(4) Headache of nasal vasomotor reaction.(5) Headache of delusional, conversional, or hypochondriacal states.(6) Non-migrainous vascular headaches: A Systemic infections, B Miscellaneous disorders.