Development and Validation of a Modified Full Age Spectrum Creatinine-Based Equation to Estimate Glomerular Filtration Rate
Authors: Hans Pottel, Pierre Delanaye
Journal: Annals of Internal Medicine (2021)

LettersJuly 2021Development and Validation of a Modified Full Age Spectrum Creatinine-Based Equation to Estimate Glomerular Filtration RateHans Pottel, PhD, Pierre Delanaye, MD, PhDHans Pottel, PhDKU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium, Pierre Delanaye, MD, PhDUniversity of Liège (ULg CHU), CHU Sart Tilman, Liège, Belgium, and Hôpital Universitaire Carémeau, Nîmes, FranceAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L21-0248 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE: The goal of eGFR equations is to predict measured GFR (mGFR). The age cutoff in the EKFC equation was chosen on the basis of dedicated studies establishing the age dependency of mGFR and the age/sex dependency of SCr. Indeed, mGFR in healthy participants was shown to be stable around 107 mL/min/1.73 m2 until approximately age 40 years. It then starts to decline (1, 2) independent of how SCr evolves with age, which is entirely different (3). This difference in the SCr–age pattern compared with how mGFR evolves with age is the main reason why eGFR equations were developed ...References1. Pottel H, Hoste L, Yayo E, et al. Glomerular filtration rate in healthy living potential kidney donors: a meta-analysis supporting the construction of the full age spectrum equation. Nephron. 2017;135:105-19. [PMID: 27764827] doi:10.1159/000450893 CrossrefMedlineGoogle Scholar2. Pottel H, Delanaye P, Weeders L, et al. Age-dependent reference intervals for estimated and measured glomerular filtration rate. Clin Kidney J. 2017;10:545-51. [PMID: 28852494] doi:10.1093/ccl/sfx026 CrossrefMedlineGoogle Scholar3. Pottel H, Vrydags N, Mahieu B, et al. Establishing age/sex related serum creatinine reference intervals from hospital laboratory data based on different statistical methods. Clin Chim Acta. 2008;396:49-55. [PMID: 18621041] doi:10.1016/j.cca.2008.06.017 CrossrefMedlineGoogle Scholar4. Pottel H, Hoste L, Dubourg L, et al. An estimated glomerular filtration rate equation for the full age spectrum. Nephrol Dial Transplant. 2016;31:798-806. [PMID: 26932693] doi:10.1093/ndt/gfv454 CrossrefMedlineGoogle Scholar5. Pottel H, Delanaye P, Schaeffner E, et al. Estimating glomerular filtration rate for the full age spectrum from serum creatinine and cystatin C. Nephrol Dial Transplant. 2017;32:497-507. [PMID: 28089986] doi:10.1093/ndt/gfw425 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: KU Leuven Campus Kulak Kortrijk, Kortrijk, BelgiumUniversity of Liège (ULg CHU), CHU Sart Tilman, Liège, Belgium, and Hôpital Universitaire Carémeau, Nîmes, FranceDisclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M20-4366. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDevelopment and Validation of a Modified Full Age Spectrum Creatinine-Based Equation to Estimate Glomerular Filtration Rate Hans Pottel , Jonas Björk , Marie Courbebaisse , Lionel Couzi , Natalie Ebert , Björn O. Eriksen , R. Neil Dalton , Laurence Dubourg , François Gaillard , Cyril Garrouste , Anders Grubb , Lola Jacquemont , Magnus Hansson , Nassim Kamar , Edmund J. Lamb , Christophe Legendre , Karin Littmann , Christophe Mariat , Toralf Melsom , Lionel Rostaing , Andrew D. Rule , Elke Schaeffner , Per-Ola Sundin , Stephen Turner , Arend Bökenkamp , Ulla Berg , Kajsa Åsling-Monemi , Luciano Selistre , Anna Åkesson , Anders Larsson , Ulf Nyman , and Pierre Delanaye Development and Validation of a Modified Full Age Spectrum Creatinine-Based Equation to Estimate Glomerular Filtration Rate Emmanuelle Vidal-Petiot , Jimmy Mullaert , Nahid Tabibzadeh , and Martin Flamant Metrics Cited byThe new, race-free, Chronic Kidney Disease Epidemiology Consortium (CKD-EPI) equation to estimate glomerular filtration rate: is it applicable in Europe? A position statement by the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)Calculation of the estimated glomerular filtration rate using the 2021 CKD-EPI creatinine equation and whole blood creatinine values measured with Radiometer ABL 827 FLEXThe impact of the new CKD-EPI equation on GFR estimation in the elderlyApplicability of Creatinine-based equations for estimating glomerular filtration rate in elderly Chinese patientsFolic Acid Attenuates Contrast-Induced Nephropathy in Patients With Hyperhomocysteinemia Undergoing Coronary Catheterization: A Randomized Controlled Trial July 2021Volume 174, Issue 7Page: 1038KeywordsAdolescentsAttentionChildrenChronic kidney diseaseCreatinineEpidemiologyGlomerular filtration rateKidneysPopulation statisticsYoung adults ePublished: 20 July 2021 Issue Published: July 2021 Copyright & PermissionsCopyright © 2021 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...