tbuckley/cabot-search huggingface dataset:
Racial and Ethnic Differences in Marijuana Use in e-Cigarettes Among US Youth in 2017, 2018, and 2020
Authors: Christina V. Watson, Samantha Puvanesarajah, Katrina F. Trivers
Journal: JAMA Pediatrics (2021)

43 000 already affected.For comparison, the attacks on September 11, 2001, left 3000 children without a parent. 5The burden will grow heavier as the death toll continues to mount.Black children are disproportionately affected, comprising only 14% of children in the US but 20% of those losing a parent to COVID-19. 6We note these estimates rely on demographic modeling, not survey or administrative data.Moreover, they do not include bereavement of nonparental primary caregivers.Sweeping national reforms are needed to address the health, educational, and economic fallout affecting children.Parentally bereaved children will also need targeted support to help with grief, particularly during this period of heightened social isolation.Brief evidence-based interventions may be able to prevent the development of severe psychological problems when delivered widely, 1 although some children will need longer-term support.The establishment of a national child bereavement cohort could identify children who have lost parents, monitor them for early identification of emerging challenges, link them to locally delivered care, and form the basis for a longitudinal study of the long-term effects of mass parental bereavement during a uniquely challenging time of social isolation and economic uncertainty.
Associations between body-mass index and COVID-19 severity in 6·9 million people in England: a prospective, community-based, cohort study
Authors: Min Gao, Carmen Piernas, Nerys M Astbury, Julia Hippisley-Cox, Stephen O'Rahilly, Paul Aveyard, Susan A Jebb
Journal: The Lancet Diabetes & Endocrinology (2021)
DOES DIGITAL HEALTH EXACERBATE EXISTING INEQUITIES? EXAMINING SOCIODEMOGRAPHIC PREDICTORS OF DIGITAL HEALTH INTERVENTION USE FOR READMISSION REDUCTION POST-MI
Authors: Lochan M. Shah, Jie Ding, Erin Spaulding, William Yang, Matthias Lee, Ryan Demo, Francoise Marvel, Seth Martin
Journal: Journal of the American College of Cardiology (2021)
THE ASSOCIATION BETWEEN CHANGES IN PEAK OXYGEN UPTAKE FOLLOWING PHASE II OUTPATIENT CARDIAC REHABILITATION AND MAJOR ADVERSE CARDIOVASCULAR EVENTS: A COMMUNITY COHORT
Authors: Audry Chacin-Suarez, Jose Medina-Inojosa, Jenna L. Taylor, Joshua Smith, Ray Squires, Thomas Olson, Amanda Bonikowske
Journal: Journal of the American College of Cardiology (2021)
TRANSCATHETER PULMONIC VALVE IN VALVE REPLACEMENT IN REPAIRED TETRALOGY OF FALLOT: A MULTIMODALITY IMAGING CASE STUDY
Authors: Saikrishna Patibandla, Mouhamed Amr Sabouni, M. Sertac Cicek, Pieter A. Verhoeven, Bryan Raybuck, Madhavi Kadiyala
Journal: Journal of the American College of Cardiology (2021)
Abstract 10970: Independent and Joint Associations of Obesity, Physical Activity, and Galectin-3: The Atherosclerosis Risk in Communities Study (ARIC)
Authors: Roberta Florido, Vijay Nambi, Lucia Kwak, Ron C Hoogeveen, Mariana Lazo, Gary Gerstenblith, Roger S Blumenthal, Josef Coresh, Aaron R Folsom, Elizabeth Selvin, Christie M Ballantyne, Chiadi E Ndumele
Journal: Circulation (2018)

Background: Obesity and low physical activity (PA) are interrelated risk factors for heart failure (HF) via incompletely understood mechanisms. Galectin-3 (gal-3) is a marker of inflammation and fi...
Metronomic therapy with Cyclophosphamide or Doxorubicin inhibits mouse mammary adenocarcinoma growth and metastasis development
Authors: Leandro E. Mainetti, Viviana R. Rozados, R. Daniel Bonfil, O. Graciela Scharovsky
Journal: Cancer Research (2005)

5852  Metronomic therapy consists of a chronic, equally spaced, administration of low doses of different chemotherapeutic drugs without rest periods. We have previously demonstrated a complete eradication of rat lymphomas, as well as of a high percentage of rat sarcomas, by low dose Cy metronomic therapy devoid of toxicity. To confirm the efficacy of this treatment, herein we tested metronomic therapy in a mouse mammary adenocarcinoma tumor model (M-234p) using Cyclophosphamide (Cy) or Doxorubicin (Dox). BALB/c mice were s.c. challenged on day 0 with M-234p fragments and treated either orally with Cy (0.2 mg/ml in drinking water) from day 10 on, or i.p. with Dox (1 mg/kg body weight) from day 8 on, two times/week. The respective control groups were treated with the vehicle using the same administration route and the same schedule. Tumors were measured and animals were weighted twice a week. A significant inhibition of tumor growth was evident in treated mice (mean tumor volume ± S.E.: on day 27, Cy-treated: 1178 ± 375 mm3 vs. Control: 4082 ± 1652 mm3, p
Solubilized ubiquinol for preserving corneal function
Authors: Youssef W. Naguib, Sanjib Saha, Jessica M. Skeie, Timothy Acri, Kareem Ebeid, Somaya Abdel-rahman, Sandeep Kesh, Gregory A. Schmidt, Darryl Y. Nishimura, Jeffrey A. Banas, Min Zhu, Mark A. Greiner, Aliasger K. Salem
Journal: Biomaterials (2021)
Abstract 17109: Time Of Day Does Not Influence Mortality In Patients Undergoing Surgical Repair Of Acute Type A Aortic Dissection
Authors: George Arnaoutakis, Christoph A Nienaber, Anthony L Estrera, Derek R Brinster, Marek P Ehrlich, Mark D Peterson, Eduardo Bossone, Truls Myrmel, Davide Pacini, Daniel G Montgomery, Kim A Eagle, Raffi Bekeredijan, Sherene Shalhub, Carlo De Vincentiis, G Chad Hughes, Edward P Chen, Hans-Henning Eckstein, Ibrahim Sultan
Journal: Circulation (2019)

Introduction: Patients with acute conditions such as myocardial infarction and cardiac arrest have been found to have worse outcomes when occurring at off hours. Acute type A aortic dissection (TAA...
REMNANT CHOLESTEROL IN PATIENTS WITH ESTABLISHED CORONARY ARTERY DISEASE PREDICTS CARDIOVASCULAR EVENTS BOTH AMONG PATIENTS WITH TYPE 2 DIABETES AND AMONG NON-DIABETIC SUBJECTS
Authors: Christoph H. Saely, Maximilian Maechler, Arthur Mader, Barbara Larcher, Lukas Sprenger, Beatrix Mutschlechner, Margaretha Klement, Daniela Zanolin-Purin, Andreas Leiherer, Axel Muendlein, Alexander Vonbank, Heinz Drexel
Journal: Journal of the American College of Cardiology (2021)
TWO-CENTRE ANALYSIS OF CARDIAC AMYLOIDOSIS PATIENTS IN CARDIOGENIC SHOCK REQUIRING TEMPORARY MECHANICAL CIRCULATORY SUPPORT
Authors: Salil Kumar, Varinder Randhawa, Ran Lee, Lauren Ives, Edward G. Soltesz, Michael Z.Y. Tong, Randall C. Starling, Jaime Hernandez-Montfort, Hanna Mazen, Barry Trachtenberg, Jerry Estep
Journal: Journal of the American College of Cardiology (2021)
Weight Gain After Smoking Cessation and Risk of Major Chronic Diseases and Mortality
Authors: Berhe W. Sahle, Wen Chen, Lal B. Rawal, Andre M. N. Renzaho
Journal: JAMA Network Open (2021)

<h3>Importance</h3> Smoking cessation is frequently followed by weight gain; however, whether weight gain after quitting reduces the health benefits of quitting is unclear. <h3>Objective</h3> To examine the association between weight change after smoking cessation and the risk of cardiovascular diseases (CVD), type 2 diabetes, cancer, chronic obstructive pulmonary disease (COPD), and all-cause mortality. <h3>Design, Setting, and Participants</h3> This cohort study analyzed data from a nationally representative sample of Australian adults aged 18 years or older who were studied between 2006 and 2014. Smoking status and anthropometric measurements were self-reported annually. Cox proportional hazards regressions were used to determine the hazard ratios (HRs) for the association between changes in weight and body mass index (BMI) and the risk of CVD, type 2 diabetes, cancer, COPD, and mortality. Data were analyzed in January 2019. <h3>Exposures</h3> Annual self-reported smoking status; years since quitting. <h3>Main Outcomes and Measures</h3> Weight gain after quitting, incident CVD, type 2 diabetes, cancer, COPD, and all-cause mortality. <h3>Results</h3> Of a total 16 663 participants (8082 men and 8581 women; mean [SD] age, 43.7 [16.3] years), those who quit smoking had greater increases in weight (mean difference [MD], 3.14 kg; 95% CI, 1.39-4.87) and BMI (MD, 0.82; 95% CI, 0.21-1.44) than continuing smokers. Compared with continuing smokers, the HRs for death were 0.50 (95% CI, 0.36-0.68) among quitters who lost weight, 0.79 (95% CI, 0.51-0.98) among quitters without weight change, 0.33 (95% CI, 0.21-0.51) among quitters who gained 0.1 to 5.0 kg, 0.24 (95% CI, 0.11-0.53) among quitters who gained 5.1 to 10 kg, and 0.36 (95% CI, 0.16-0.82) among quitters who gained more than 10 kg. The HRs for death were 0.61 (95% CI, 0.45-0.83) among quitters who lost BMI, 0.86 (95% CI, 0.51-1.44) among quitters without change in BMI, 0.32 (95% CI, 0.21-0.50) among quitters who gained up to 2 in BMI, and 0.26 (95% CI, 0.16-0.45) among quitters who gained more than 2 in BMI. <h3>Conclusions and Relevance</h3> This cohort study found that smoking cessation was accompanied by a substantial weight gain; however, this was not associated with an increased risk of chronic diseases or an attenuation of the mortality benefit of cessation.
Clinical features and sex hormone profile in male patients with frontal fibrosing alopecia: A multicenter retrospective study with 33 patients
Authors: Isabella Doche, Marcello M.S. Nico, Paula Gerlero, Marina Rebeis, Daniel F. Melo, Violeta Tortelly, Paulo M. Ramos, Jorge Larrondo, Felipe Mardones, Martha L. González, Antonella Tosti, Maria Cecília Rivitti-Machado
Journal: Journal of the American Academy of Dermatology (2021)
Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition
Authors: Gianni Carraro, Justin Langerman, Shan Sabri, Zareeb Lorenzana, Arunima Purkayastha, Guangzhu Zhang, Bindu Konda, Cody J. Aros, Ben A. Calvert, Aleks Szymaniak, Emily Wilson, Michael Mulligan, Priyanka Bhatt, Junjie Lu, Preethi Vijayaraj, Changfu Yao, David W. Shia, Andrew J. Lund, Edo Israely, Tammy M. Rickabaugh, Jason Ernst, Martin Mense, Scott H. Randell, Eszter K. Vladar, Amy L. Ryan, Kathrin Plath, John E. Mahoney, Barry R. Stripp, Brigitte N. Gomperts
Journal: Nature Medicine (2021)
BASELINE CHARACTERISTICS AND OUTCOMES BASED ON RENAL TRANSPLANT LISTING STATUS IN THE ISCHEMIA-CKD TRIAL
Authors: Charles Herzog, Mengistu Simegn, Yifan Xu, Salvatore Costa, Marina Vieira, Roy Mathew, Mohammad El-Hajjar, Sanjeev Gulati, Rafael Maldonado, Eric Daugas, Jerome Fleg, Rebecca Anthopolos, Mandeep Sidhu, David Maron, Judith Hochman, Sripal Bangalore
Journal: Journal of the American College of Cardiology (2021)
EFFECT OF SACUBITRIL/VALSARTAN ON ELECTRICAL AND STRUCTURAL REVERSE REMODELING IN PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION
Authors: Anas Abudan, Farhad Sami, Uzair Mahmood, Nikhil Parimi, Colton Schwarz, Michael Pierpoline, Moghniuddin Mohammed, Raghuveer Dendi, Rhea Pimentel, Loren Berenbom, Martin Emert, Rigoberto Ramirez, Amit Noheria, Madhu Reddy, Andrew Sauer, Bhanu Gupta, Seth Sheldon
Journal: Journal of the American College of Cardiology (2021)
EFFECT OF IONIS-AGT-LRX, AN ANTISENSE INHIBITOR OF ANGIOTENSINOGEN PRODUCTION, IN HEALTHY VOLUNTEERS AND IN SUBJECTS WITH HYPERTENSION: RESULTS OF PHASE 1 AND PHASE 2 STUDIES
Authors: Erin Morgan, Yvonne Tami, Kevin Hu, Adam Mullick, Richard Geary, Sotirios Tsimikas
Journal: Journal of the American College of Cardiology (2021)
BLOOD PRESSURE TRAJECTORIES AND OUTCOMES IN NIGERIANS WITH PERIPARTUM CARDIOMYOPATHY
Authors: Kamilu Musa Karaye, Hadiza Sa'idu, Balarabe Sulaiman, Naser Ishaq, Umar Gati Adamu, Idris Y. Mohammed, Oboirien Isa, Ejiroghene Umuerri, Abaram Mankwe, Vincent Shidali, Paschal Njoku, Sotonye Dodiyi-Manuel, Taiwo Olunuga, Veronica Josephs, Amam Mbakwem, Mohammed Talle, Henry Okolie, Mohammed Sani Isa, Muhammad Nazeer Shehu, Okechukwu S. Ogah
Journal: Journal of the American College of Cardiology (2021)
CORONARY ARTERY DISEASE PROGRESSION IN PATIENTS WITH END-STAGE LIVER DISEASE: FINDINGS FROM CCTA MAY IMPACT PREOPERATIVE CARDIAC TESTING RECOMMENDATIONS
Authors: Zachary Neace, Caleb W. Phillips, Gregory Sinner, Talal S. Alnabelsi, Malay B. Shah, Roberto Gedaly, Vedant Gupta, Vincent Sorrell, Steve Leung
Journal: Journal of the American College of Cardiology (2021)
FACILITY LEVEL VARIATION IN THE REPORTING OF STATIN-ASSOCIATED SIDE EFFECTS AMONG PATIENTS WITH ATHEROSCLEROTIC CARDIOVASCULAR DISEASE
Authors: Xiaoming Jia, Michelle Lee, David Ramsey, Mahmoud Al Rifai, Dhruv Mahtta, Chayakrit Krittanawong, Julia Akeroyd, Michael Matheny, Glenn Gobbel, Neil Stone, Christie Ballantyne, Laura Petersen, Salim Virani
Journal: Journal of the American College of Cardiology (2021)
Abstract #4625: Effect of NAMI-A on K-Ras-mediated oncogenic transformation and signal transduction
Authors: Natalie Ausborn, John Croft, Katie Alexander, Laura Stultz, Gretchen Repasky
Journal: Cancer Research (2009)

The ruthenium-based drug imidazolium trans-imidazoledimethlysulfoxide-tetrachlororuthenate (NAMI-A) has previously demonstrated anti-proliferative and anti-metastatic effects, in addition to limited cellular and host toxicity. The goal of this study was to evaluate effects of NAMI-A on rat intestinal epithelial (RIE-1) cells transformed by K-Ras 12V. A K-Ras 12V genetic mutation causes the Ras GTPase to be chronically activated, leading to unregulated cell cycle progression, altered morphology, and other cancer cell phenotypes. RIE-1 cells were treated with NAMI-A, and effects on cytotoxicity, proliferation, anchorage-independent growth, invasion, morphology, and signal transduction downstream of Ras were investigated. NAMI-A, at concentrations up to 200 \#956;M, was nontoxic to RIE-1 cells, and NAMI-A selectively reduced anchorage-independent proliferation and inhibited Matrigel invasion of Ras-transformed cells. Exposure of either nontransformed or Ras-transformed cells to NAMI-A for up to twenty-four hours did not alter cell morphology. Finally, western analysis was used to examine activation of ERK (extracellular-regulated protein kinase) and Akt kinase, effector pathways downstream of Ras and involved in progression and maintenance of the transformed state. NAMI-A treatment caused an upregulation of both ERK and Akt activation, as shown by an increase in phosphorylation, in nontransformed cells and caused a slight downregulation of Akt activation in Ras-transformed cells. Given that the anti-proliferative and anti-metastatic effects of NAMI-A on RIE-1 cells have been previously shown to be selective towards the Ras-transformed cells, this study proposed an interesting shift to the potential effects of NAMI-A on molecular pathways downstream of Ras in nontransformed cells. Taken together, our studies indicate that NAMI-A exhibits anticancer effects in Ras-transformed cells and upregulates ERK and Akt activation in nontransformed cells. These studies provide novel evidence of the selective anticancer effects of NAMI-A in Ras-transformed RIE-1 cells as well as novel effects of NAMI-A on Akt, suggesting that NAMI-A could target other proteins that lie upstream of both ERK and Akt signaling.  Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 4625.
REVASCULARIZATION VERSUS MEDICAL THERAPY ALONE FOR STABLE ANGINA IN VERY ELDERLY PATIENTS &gt; 80 YEARS OLD
Authors: Derek Phan, Brendan Kim, Ming-Sum Lee, Naing Moore, Prakash Mansukhani, Vicken Aharonian, Somjot Brar, Ray Zadegan
Journal: Journal of the American College of Cardiology (2021)
LEFT ATRIAL STRAIN AND DIASTOLIC DYSFUNCTION AMONGST HIV-POSITIVE INDIVIDUALS: INSIGHTS FROM THE VETERANS AGING COHORT STUDY
Authors: Christopher Berg, Bobby Patel, Maxwell Reynolds, Mirela Tuzovic, Kara Chew, Jason Sico, Debika Bhattacharya, Adeel A. Butt, Joseph K. Lim, Roger J. Bedimo, Sheldon T. Brown, John Gottdiener, Alberta Warner, Matthew Freiberg, Kaku So-Armah, Kim-Lien Nguyen
Journal: Journal of the American College of Cardiology (2021)
Stress and imagining future selves: resolve in the hot/cool framework
Authors: Janet Metcalfe, William James Jacobs
Journal: Behavioral and Brain Sciences (2021)

Abstract Although Ainslie dismisses the hot/cool framework as pertaining only to suppression, it actually also has interesting implications for resolve. Resolve focally involves access to our future selves. This access is a cool system function linked to episodic memory. Thus, factors negatively affecting the cool system, such as stress, are predicted to impact two seemingly unrelated capabilities: willpower and episodic memory.
Response to: ‘Correspondence on ‘SARS-CoV-2 vaccine hesitancy among patients with rheumatic and musculoskeletal diseases: a message for rheumatologists’’ by Smerilli <i>et al</i>
Authors: Roberta Priori, Greta Pellegrino, Serena Colafrancesco, Cristiano Alessandri, Fulvia Ceccarelli, Manuela Di Franco, Valeria Riccieri, Rossana Scrivo, Antonio Sili Scavalli, Francesca Romana Spinelli, Fabrizio Conti
Journal: Annals of the Rheumatic Diseases (2021)

A young girl in her teens presented with fever, rashes and various mucocutaneous symptoms. Flat erythematous macules were seen mainly on the limbs, without blisters or skin detachments. The lips were swollen with crusts and haemorrhage. The oral cavity and pharynx showed ulcerative lesions with exudate. Severe bilateral ocular lesions with pseudomembrane formation and corneal epithelial defects were present. Also, urogenital lesion and gastrointestinal symptoms with frequent haematochezia were observed. Her symptoms and pathological findings were consistent with Stevens-Johnson syndrome. She was treated with prednisolone and methylprednisolone pulse therapy. Her ocular and cutaneous symptoms improved without severe chronic complications. However, 1 month later, she developed dyspnoea, and a pulmonary function test revealed severe obstructive ventilation disorder. After discharge, she was regularly followed up for respiratory complications. High-resolution chest CT performed 9 months after onset revealed mosaic perfusions and bronchiectasis, consistent with bronchiolitis obliterans.
Chemogenetic stimulation of proprioceptors remodels lumbar interneuron excitability and promotes motor recovery after SCI
Authors: Zhongyang Gao, Yang Yang, Zhiyun Feng, Xigong Li, Cuiting Min, Zhonghai Zhu, Hui Song, Yihe Hu, Yue Wang, Xijing He
Journal: Molecular Therapy (2021)

Motor recovery after severe spinal cord injury (SCI) is limited due to the disruption of direct descending commands. Despite the absence of brain-derived descending inputs, sensory afferents below injury sites remain intact. Among them, proprioception acts as an important sensory source to modulate local spinal circuits and determine motor outputs. Yet, it remains unclear whether enhancing proprioceptive inputs promotes motor recovery after severe SCI. Here, we first established a viral system to selectively target lumbar proprioceptive neurons and then introduced the excitatory Gq-coupled Designer Receptors Exclusively Activated by Designer Drugs (DREADD) virus into proprioceptors to achieve specific activation of lumbar proprioceptive neurons upon CNO administration. We demonstrated that chronic activation of lumbar proprioceptive neurons promoted the recovery of hindlimb stepping ability in a bilateral hemisection SCI mouse model. We further revealed that chemogenetic proprioceptive stimulation led to coordinated activation of proprioception-receptive spinal interneurons and facilitated transmission of supraspinal commands to lumbar motor neurons, without affecting the regrowth of proprioceptive afferents or brain-derived descending axons. Moreover, application of 4-aminopyridine-3-methanol (4-AP-MeOH) that enhances nerve conductance further improved the transmission of supraspinal inputs and motor recovery in proprioception-stimulated mice. Our study demonstrates that proprioception-based combinatorial modality may be a promising strategy to restore the motor function after severe SCI.
Nucleic Acid–based Testing for Noninfluenza Viral Pathogens in Adults with Suspected Community-acquired Pneumonia. An Official American Thoracic Society Clinical Practice Guideline
Authors: Scott E. Evans, Ann L. Jennerich, Marwan M. Azar, Bin Cao, Kristina Crothers, Robert P. Dickson, Susanne Herold, Seema Jain, Ann Madhavan, Mark L. Metersky, Laura C. Myers, Eyal Oren, Marcos I. Restrepo, Makeda Semret, Ajay Sheshadri, Richard G. Wunderink, Charles S. Dela Cruz
Journal: American Journal of Respiratory and Critical Care Medicine (2021)

Background: This document provides evidence-based clinical practice guidelines on the diagnostic utility of nucleic acid-based testing of respiratory samples for viral pathogens other than influenza in adults with suspected community-acquired pneumonia (CAP).Methods: A multidisciplinary panel developed a Population-Intervention-Comparison-Outcome question, conducted a pragmatic systematic review, and applied Grading of Recommendations, Assessment, Development, and Evaluation methodology for clinical recommendations.Results: The panel evaluated the literature to develop recommendations regarding whether routine diagnostics should include nucleic acid-based testing of respiratory samples for viral pathogens other than influenza in suspected CAP. The evidence addressing this topic was generally adjudicated to be of very low quality because of risk of bias and imprecision. Furthermore, there was little direct evidence supporting a role for routine nucleic acid-based testing of respiratory samples in improving critical outcomes such as overall survival or antibiotic use patterns. However, on the basis of direct and indirect evidence, recommendations were made for both outpatient and hospitalized patients with suspected CAP. Testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was not addressed in the literature at the time of the evidence review.Conclusions: The panel formulated and provided their rationale for recommendations on nucleic acid-based diagnostics for viral pathogens other than influenza for patients with suspected CAP.
Abstract 16270: Feature-Tracking Strain From Cardiac MRI Mapping Assesses Diagnosis, Severity, and Prognosis in Myocarditis
Authors: Alvaro J Garcia-Ropero, Carlos G SantosGallego, Chirag J Agarwal, Allen Weiss, Rebecca Smoller, Valentin Fuster, Juan J Badimon, Javier Sanz
Journal: Circulation (2018)

Introduction: Cardiac magnetic resonance (CMR) has excellent diagnostic accuracy in patients with suspected myocarditis. The role of CMR-assessed strain (using feature tracking; FT) in myocarditis ...
Application of Artificial Intelligence for Diagnosis and Risk Stratification in NAFLD and NASH: The State of the Art
Authors: Amreen M. Dinani, Kris V. Kowdley, Mazen Noureddin
Journal: Hepatology (2021)

The diagnosis of nonalcoholic fatty liver disease and associated fibrosis is challenging given the lack of signs, symptoms and nonexistent diagnostic test. Furthermore, follow up and treatment decisions become complicated with a lack of a simple reproducible method to follow these patients longitudinally. Liver biopsy is the current standard to detect, risk stratify and monitor individuals with nonalcoholic fatty liver disease. However, this method is an unrealistic option in a population that affects about one in three to four individuals worldwide. There is an urgency to develop innovative methods to facilitate management at key points in an individual’s journey with nonalcoholic fatty liver disease fibrosis. Artificial intelligence is an exciting field that has the potential to achieve this. In this review, we highlight applications of artificial intelligence by leveraging our current knowledge of nonalcoholic fatty liver disease to diagnose and risk stratify NASH phenotypes.