tbuckley/cabot-search huggingface dataset:
Annals Story Slam - A Love Story
Authors: Anne Furey Schultz
Journal: Annals of Internal Medicine (2022)

Web Exclusives29 April 2022Annals Story Slam - A Love StoryFREEAnne Furey Schultz, MDAnne Furey Schultz, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/W22-0005 SectionsAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Video. Annals Story Slam - A Love Story "A Love Story," by Dr. Anne Furey Schultz (Duration 5:51)Building on the popular Annals feature “On Being a Doctor,” storytellers share stories about the experience of doctoring on video.For more videos from and information on Annals Story Slam, visit go.annals.org/StorySlam. Author, Article, and Disclosure InformationAuthors: Anne Furey Schultz, MDCorresponding Author: Anne Furey Schultz, MD; e-mail, annefschultz@gmail.com.This article was published at Annals.org on 29 April 2022. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics June 2022Volume 175, Issue 6Page: SS1 ePublished: 29 April 2022 Issue Published: June 2022 Copyright & PermissionsCopyright © 2022 by American College of Physicians. All Rights Reserved.Loading ...
Metastatic Death Based on Presenting Features and Treatment for Advanced Intraocular Retinoblastoma
Authors: Ankit Singh Tomar, Paul T. Finger, Brenda Gallie, Tero T. Kivelä, Ashwin Mallipatna, Chengyue Zhang, Junyang Zhao, Matthew W. Wilson, Rachel C. Brennan, Michala Burges, Jonathan Kim, Jesse L. Berry, Rima Jubran, Vikas Khetan, Suganeswari Ganesan, Andrey Yarovoy, Vera Yarovaya, Elena Kotova, Denis Volodin, Yacoub A. Yousef, Kalle Nummi, Tatiana L. Ushakova, Olga V. Yugay, Vladimir G. Polyakov, Marco A. Ramirez-Ortiz, Elizabeth Esparza-Aguiar, Guillermo Chantada, Paula Schaiquevich, Adriana Fandino, Jason C. Yam, Winnie W. Lau, Carol P. Lam, Phillipa Sharwood, Sonia Moorthy, Quah Boon Long, Vera Adobea Essuman, Lorna A. Renner, Ekaterina Semenova, Jaume Català-Mora, Genoveva Correa-Llano, Elisa Carreras
Journal: Ophthalmology (2022)

To evaluate presenting features, tumor size, and treatment methods for risk of metastatic death due to advanced intraocular retinoblastoma (RB).International, multicenter, registry-based retrospective case series.A total of 1841 patients with advanced RB.Advanced RB was defined by 8th edition American Joint Committee on Cancer (AJCC) categories cT2 and cT3 and new AJCC-Ophthalmic Oncology Task Force (OOTF) Size Groups (1: < 50% of globe volume, 2: > 50% but < 2/3, 3: > 2/3, and 4: diffuse infiltrating RB). Treatments were primary enucleation, systemic chemotherapy with secondary enucleation, and systemic chemotherapy with eye salvage.Metastatic death.The 5-year Kaplan-Meier cumulative survival estimates by patient-level AJCC clinical subcategories were 98% for cT2a, 96% for cT2b, 88% for cT3a, 95% for cT3b, 92% for cT3c, 84% for cT3d, and 75% for cT3e RB. Survival estimates by treatment modality were 96% for primary enucleation, 89% for systemic chemotherapy and secondary enucleation, and 90% for systemic chemotherapy with eye salvage. Risk of metastatic mortality increased with increasing cT subcategory (P < 0.001). Cox proportional hazards regression analysis confirmed a higher risk of metastatic mortality in categories cT3c (glaucoma, hazard ratio [HR], 4.9; P = 0.011), cT3d (intraocular hemorrhage, HR, 14.0; P < 0.001), and cT3e (orbital cellulitis, HR, 19.6; P < 0.001) than in category cT2a and with systemic chemotherapy with secondary enucleation (HR, 3.3; P < 0.001) and eye salvage (HR, 4.9; P < 0.001) than with primary enucleation. The 5-year Kaplan-Meier cumulative survival estimates by AJCC-OOTF Size Groups 1 to 4 were 99%, 96%, 94%, and 83%, respectively. Mortality from metastatic RB increased with increasing Size Group (P < 0.001). Cox proportional hazards regression analysis revealed that patients with Size Group 3 (HR, 10.0; P = 0.002) and 4 (HR, 41.1; P < 0.001) had a greater risk of metastatic mortality than Size Group 1.The AJCC-RB cT2 and cT3 subcategories and size-based AJCC-OOTF Groups 3 (> 2/3 globe volume) and 4 (diffuse infiltrating RB) provided a robust stratification of clinical risk for metastatic death in advanced intraocular RB. Primary enucleation offered the highest survival rates for patients with advanced intraocular RB.
Macrophage mitochondrial fission improves cancer cell phagocytosis induced by therapeutic antibodies and is impaired by glutamine competition
Authors: Jiang Li, Yingying Ye, Zhihan Liu, Guoyang Zhang, Huiqi Dai, Jiaqian Li, Boxuan Zhou, Yihong Li, Qiyi Zhao, Jingying Huang, Jingwei Feng, Shu Liu, Peigang Ruan, Jinjing Wang, Jiang Liu, Min Huang, Xinwei Liu, Shubin Yu, Ziyang Liang, Liping Ma, Xiaoxia Gou, Guoliang Zhang, Nian Chen, Yiwen Lu, Can Di, Qidong Xia, Jiayao Pan, Ru Feng, Qingqing Cai, Shicheng Su
Journal: Nature Cancer (2022)
Correspondence on ‘No efficacy of anti-IL-23 therapy for axial spondyloarthritis in randomised controlled trials but in post-hoc analyses of psoriatic arthritis-related ‘physician-reported spondylitis’?’
Authors: Dafna D Gladman, Philip J Mease, Paul Bird, Enrique R Soriano, Soumya D Chakravarty, May Shawi, Frederic Lavie, Cinty Gong, Evan Leibowitz, Denis Poddubnyy, Lai-Shan Tam, Philip S Helliwell, Arthur Kavanaugh, Atul A Deodhar, Mikkel Østergaard, Xenofon Baraliakos
Journal: Annals of the Rheumatic Diseases (2022)
Right Precordial U Waves in Severe Aortic Stenosis
Authors: Joshua Lampert, Matthew Pulaski, Marc A. Miller, William Whang, Jacob Koruth, Benjamin Glicksberg, Samin Sharma, Srinivas R. Dukkipati, Valentin Fuster, Vivek Y. Reddy
Journal: Journal of the American College of Cardiology (2022)
The Regulation of Gonadal Somatic Cell Differentiation in Humans
Authors: Min Chen, Fei Gao
Journal: Genomics Proteomics & Bioinformatics (2022)

In mammals, both male and female gonads are derived from the bipotential gonadal primordium, i.e., the genital ridge. The differentiation of germ cells and gonadal somatic cells during gonad development is regulated by various factors, including transcription factors, epigenetic regulators, and environmental factors. The interactions between germ cells and somatic cells also play critical roles in gonad development and PGC differentiation. The regulation of PGC and gonadal somatic cell development in mouse models has been extensively investigated previously. However, the regulation of gonadal somatic cell differentiation and the interactions between germ cells and gonadal somatic cells in humans still remain incompletely understood. Wang et al. have systematically analyzed the regulation of FGC and gonadal somatic cell development and identified and characterized new types of FGCs and gonadal somatic cells. They have proposed that the DLK1 + cell population is a progenitor population of the steroidogenic cell lineage and the TAC1 + cell population is a progenitor population of granulosa cells. Notably, they have demonstrated the crosstalk between BMP and RA signaling pathways by functional assays. The single-cell omics studies are greatly helping advancing the human developmental biology, filling the gaps between the functional studies in mouse model and cell atlas studies in humans. This study provides a complex but highly ordered development and interaction network for the human FGCs and gonadal cells.
VP3-2022: Pembrolizumab (pembro) versus placebo for early-stage non-small cell lung cancer (NSCLC) following complete resection and adjuvant chemotherapy (chemo) when indicated: Randomized, triple-blind, phase III EORTC-1416-LCG/ETOP 8-15 – PEARLS/KEYNOTE-091 study
Authors: L. Paz-Ares, M.E.R. O'Brien, M. Mauer, U. Dafni, K. Oselin, L. Havel, E. Esteban Gonzalez, D. Isla, A. Martinez-Marti, M. Faehling, M. Tsuboi, J-S. Lee, K. Nakagawa, J. Yang, S.M. Keller, N. Jha, S.I. Marreaud, R.A. Stahel, S. Peters, B. Besse
Journal: Annals of Oncology (2022)
Can CPAP protect from cancer incidence in obstructive sleep apnoea patients? No evidence yet
Authors: Francesco Gambino, Maria R. Bonsignore
Journal: European Respiratory Journal (2022)

<b>Basic research has shown the biological plausibility of a relationship between OSA and cancer. However, clinical evidence of a positive effect of OSA treatment on incidence of cancer is still lacking.</b>https://bit.ly/3mqXrbI
Annals Story Slam - Driving by the Woods
Authors: Sayeeda Yasmin
Journal: Annals of Internal Medicine (2022)

Web Exclusives29 April 2022Annals Story Slam - Driving by the WoodsFREESayeeda Yasmin, MDSayeeda Yasmin, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/W22-0013 SectionsAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Video. Annals Story Slam - Driving by the Woods "Driving by the Woods," by Dr. Sayeeda Yasmin (Duration 6:04)Building on the popular Annals feature “On Being a Doctor,” storytellers share stories about the experience of doctoring on video.For more videos from and information on Annals Story Slam, visit go.annals.org/StorySlam. Author, Article, and Disclosure InformationAuthors: Sayeeda Yasmin, MDCorresponding Author: Sayeeda Yasmin, MD; e-mail, sayeeda_yasmin@yahoo.com.This article was published at Annals.org on 29 April 2022. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics June 2022Volume 175, Issue 6 Page: SS1 ePublished: 29 April 2022 Issue Published: June 2022 Copyright & PermissionsCopyright © 2022 by American College of Physicians. All Rights Reserved.Loading ...
Upfront surgery or neoadjuvant chemotherapy for colorectal liver metastases? A machine-learning decision-tree to identify the best potential policy
Authors: Simone Famularo, Flavio Milana, Mario Giuffrida, Matteo Cimino, Fabio Procopio, Guido Costa, Eloisa Franchi, Luca Viganò, Matteo Donadon, Guido Torzilli
Journal: International Journal of Surgery (2022)
Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children
Authors: Evelien R. van Meel, Sara M. Mensink-Bout, Herman T. den Dekker, Tarunveer S. Ahluwalia, Isabella Annesi-Maesano, Syed Hasan Arshad, Nour Baïz, Henrique Barros, Andrea von Berg, Hans Bisgaard, Klaus Bønnelykke, Christian J. Carlsson, Maribel Casas, Leda Chatzi, Cecile Chevrier, Geertje Dalmeijer, Carol Dezateux, Karel Duchen, Merete Eggesbø, Cornelis van der Ent, Maria Fantini, Claudia Flexeder, Urs Frey, Fransesco Forastiere, Ulrike Gehring, Davide Gori, Raquel Granell, Lucy J. Griffiths, Hazel Inskip, Joanna Jerzynska, Anne M. Karvonen, Thomas Keil, Cecily Kelleher, Manolis Kogevinas, Gudrun Koppen, Claudia E. Kuehni, Nathalie Lambrechts, Susanne Lau, Irina Lehmann, Johnny Ludvigsson, Maria Christine Magnus, Erik Mélen, John Mehegan, Monique Mommers, Anne-Marie Nybo Andersen, Wenche Nystad, Eva S.L. Pedersen, Juha Pekkanen, Ville Peltola, Katharine C. Pike, Angela Pinot de Moira, Costanza Pizzi, Kinga Polanska, Maja Popovic, Daniela Porta, Graham Roberts, Ana Cristina Santos, Erica S. Schultz, Marie Standl, Jordi Sunyer, Carel Thijs, Laura Toivonen, Eleonora Uphoff, Jakob Usemann, Marina Vafeidi, John Wright, Johan C. de Jongste, Vincent W.V. Jaddoe, Liesbeth Duijts
Journal: European Respiratory Journal (2022)

Background Early-life respiratory tract infections might affect chronic obstructive respiratory diseases, but conclusive studies from general populations are lacking. Our objective was to examine if children with early-life respiratory tract infections had increased risks of lower lung function and asthma at school age. Methods We used individual participant data of 150 090 children primarily from the EU Child Cohort Network to examine the associations of upper and lower respiratory tract infections from age 6 months to 5 years with forced expiratory volume in 1 s (FEV 1 ), forced vital capacity (FVC), FEV 1 /FVC, forced expiratory flow at 75% of FVC (FEF 75% ) and asthma at a median (range) age of 7 (4–15) years. Results Children with early-life lower, not upper, respiratory tract infections had a lower school-age FEV 1 , FEV 1 /FVC and FEF 75% (z-score range: −0.09 (95% CI −0.14– −0.04) to −0.30 (95% CI −0.36– −0.24)). Children with early-life lower respiratory tract infections had a higher increased risk of school-age asthma than those with upper respiratory tract infections (OR range: 2.10 (95% CI 1.98–2.22) to 6.30 (95% CI 5.64–7.04) and 1.25 (95% CI 1.18–1.32) to 1.55 (95% CI 1.47–1.65), respectively). Adjustment for preceding respiratory tract infections slightly decreased the strength of the effects. Observed associations were similar for those with and without early-life wheezing as a proxy for early-life asthma. Conclusions Our findings suggest that early-life respiratory tract infections affect development of chronic obstructive respiratory diseases in later life, with the strongest effects for lower respiratory tract infections.
Shifting focus from “what we do” to the “impact of what we do”: Application of outcome measures to routine clinical care in dermatology
Authors: Amit Garg, McKenzie A. Dirr, Gregor B.E. Jemec, John R. Ingram, Jochen Schmitt, Phyllis Spuls, Murad Alam
Journal: Journal of the American Academy of Dermatology (2022)
Antitumor Activity of Lurbinectedin, a Selective Inhibitor of Oncogene Transcription, in Patients with Relapsed Ewing Sarcoma: Results of a Basket Phase II Study
Authors: Vivek Subbiah, Irene Braña, Alessandra Longhi, Valentina Boni, Jean-Pierre Delord, Ahmad Awada, Pascaline Boudou-Rouquette, John Sarantopoulos, Geoffrey I. Shapiro, Anthony Elias, Ravin Ratan, Cristian Fernandez, Carmen Kahatt, Martin Cullell-Young, Mariano Siguero, Ali Zeaiter, Sant P. Chawla
Journal: Clinical Cancer Research (2022)

Abstract Purpose: Lurbinectedin suppresses the oncogenic transcription factor EWS-FLI1 through relocalization to the nucleolus, and delays tumor growth in mice bearing Ewing sarcoma xenografts. On the basis of this rationale, lurbinectedin was evaluated in patients with relapsed Ewing sarcoma. Patients and Methods: This open-label, single-arm, Basket phase II trial included a cohort of 28 treated adult patients with confirmed Ewing sarcoma, measurable disease as per Response Evaluation Criteria In Solid Tumors (RECIST) v.1.1, Eastern Cooperative Oncology Group performance status ≤2, adequate organ function, no central nervous system metastasis, and pretreated with ≤2 chemotherapy lines for metastatic/recurrent disease. Patients received lurbinectedin 3.2 mg/m2 as a 1-hour infusion every 3 weeks. Primary endpoint was overall response rate (ORR) as per RECIST v.1.1. Secondary endpoints included time-to-event parameters and safety profile. Results: ORR was 14.3% [95% confidence interval (CI), 4.0%–32.7%], with median duration of response of 4.2 months (95% CI, 2.9–5.5 months). Median progression-free survival was 2.7 months (95% CI, 1.4–4.3 months), clinical benefit rate was 39.3%, and disease control rate was 57.1%. With 39% censoring, median overall survival was 12.0 months (95% CI, 8.5–18.5 months). Most common grade 3/4 adverse events were neutropenia (57%), anemia, thrombocytopenia, and treatment-related febrile neutropenia (14% each). No deaths or discontinuations were due to toxicity. Conclusions: Lurbinectedin was active in the treatment of relapsed Ewing sarcoma and had a manageable safety profile. Lurbinectedin could represent a valuable addition to therapies for Ewing sarcoma, and is currently being evaluated in combination with irinotecan in advanced Ewing sarcoma in a phase Ib/II trial.
Paired nicking-mediated COL17A1 reframing for junctional epidermolysis bullosa
Authors: Johannes Bischof, Oliver Patrick March, Bernadette Liemberger, Simone Alexandra Haas, Stefan Hainzl, Igor Petković, Victoria Leb-Reichl, Julia Illmer, Evgeniia Korotchenko, Alfred Klausegger, Anna Hoog, Heide-Marie Binder, Marta Garcia, Blanca Duarte, Dirk Strunk, Fernando Larcher, Julia Reichelt, Christina Guttmann-Gruber, Verena Wally, Josefina Piñón Hofbauer, Johann Wolfgang Bauer, Toni Cathomen, Thomas Kocher, Ulrich Koller
Journal: Molecular Therapy (2022)

Junctional epidermolysis bullosa (JEB) is a debilitating hereditary skin disorder caused by mutations in genes encoding laminin-332, type XVII collagen (C17), and integrin-α6β4, which maintain stability between the dermis and epidermis. We designed patient-specific Cas9-nuclease- and -nickase-based targeting strategies for reframing a common homozygous deletion in exon 52 of COL17A1 associated with a lack of full-length C17 expression. Subsequent characterization of protein restoration, indel composition, and divergence of DNA and mRNA outcomes after treatment revealed auspicious efficiency, safety, and precision profiles for paired nicking-based COL17A1 editing. Almost 46% of treated primary JEB keratinocytes expressed reframed C17. Reframed COL17A1 transcripts predominantly featured 25- and 37-nt deletions, accounting for >42% of all edits and encoding C17 protein variants that localized accurately to the cell membrane. Furthermore, corrected cells showed accurate shedding of the extracellular 120-kDa C17 domain and improved adhesion capabilities to laminin-332 compared with untreated JEB cells. Three-dimensional (3D) skin equivalents demonstrated accurate and continuous deposition of C17 within the basal membrane zone between epidermis and dermis. Our findings constitute, for the first time, gene-editing-based correction of a COL17A1 mutation and demonstrate the superiority of proximal paired nicking strategies based on Cas9 D10A nickase over wild-type Cas9-based strategies for gene reframing in a clinical context.
Lifestyle Transitions in Fusarioid Fungi are Frequent and Lack Clear Genomic Signatures
Authors: Rowena Hill, Richard J.A. Buggs, Dang Toan Vu, Ester Gaya
Journal: Molecular Biology and Evolution (2022)

The fungal genus Fusarium (Ascomycota) includes well-known plant pathogens that are implicated in diseases worldwide, and many of which have been genome sequenced. The genus also encompasses other diverse lifestyles, including species found ubiquitously as asymptomatic-plant inhabitants (endophytes). Here, we produced structurally annotated genome assemblies for five endophytic Fusarium strains, including the first whole-genome data for Fusarium chuoi. Phylogenomic reconstruction of Fusarium and closely related genera revealed multiple and frequent lifestyle transitions, the major exception being a monophyletic clade of mutualist insect symbionts. Differential codon usage bias and increased codon optimisation separated Fusarium sensu stricto from allied genera. We performed computational prediction of candidate secreted effector proteins (CSEPs) and carbohydrate-active enzymes (CAZymes)-both likely to be involved in the host-fungal interaction-and sought evidence that their frequencies could predict lifestyle. However, phylogenetic distance described gene variance better than lifestyle did. There was no significant difference in CSEP, CAZyme, or gene repertoires between phytopathogenic and endophytic strains, although we did find some evidence that gene copy number variation may be contributing to pathogenicity. Large numbers of accessory CSEPs (i.e., present in more than one taxon but not all) and a comparatively low number of strain-specific CSEPs suggested there is a limited specialisation among plant associated Fusarium species. We also found half of the core genes to be under positive selection and identified specific CSEPs and CAZymes predicted to be positively selected on certain lineages. Our results depict fusarioid fungi as prolific generalists and highlight the difficulty in predicting pathogenic potential in the group.
Combination of late gadolinium enhancement and genotype improves prediction of prognosis in non‐ischaemic dilated cardiomyopathy
Authors: Jesús G. Mirelis, Luis Escobar‐Lopez, Juan Pablo Ochoa, María Ángeles Espinosa, Eduardo Villacorta, Marina Navarro, Guillem Casas, Nerea Mora‐Ayestarán, Roberto Barriales‐Villa, María Victoria Mogollón‐Jiménez, José M. García‐Pinilla, Pablo E. García‐Granja, Vicente Climent, Julian Palomino‐Doza, Ana García‐Álvarez, María Álvarez‐Barredo, Eva Cabrera‐Borrego, Tomás Ripoll‐Vera, María Luisa Peña‐Peña, Elena Rodríguez‐González, María Gallego‐Delgado, Josefa Gonzalez‐Carrillo, Ana Fernández‐Ávila, José F. Rodríguez‐Palomares, Ramón Brugada, Antoni Bayes‐Genis, Fernando Dominguez, Pablo García‐Pavía
Journal: European Journal of Heart Failure (2022)
Annals Story Slam - Alice Warren Turned 106 in February
Authors: Thomas A. Bledsoe
Journal: Annals of Internal Medicine (2022)

Web ExclusivesJune 2022Annals Story Slam - Alice Warren Turned 106 in FebruaryFREEThomas A. Bledsoe, MDThomas A. Bledsoe, MDBrown Physicians, Inc., East Providence, Rhode Island (T.A.B.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/W22-0001 SectionsAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Video. Annals Story Slam - Alice Warren Turned 106 in February "Alice Warren Turned 106 in February," by Dr. Thomas A. Bledsoe (Duration 5:38)Building on the popular Annals feature “On Being a Doctor,” storytellers share stories about the experience of doctoring on video.For more videos from and information on Annals Story Slam, visit go.annals.org/StorySlam. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: Brown Physicians, Inc., East Providence, Rhode Island (T.A.B.)Corresponding Author: Thomas A. Bledsoe, MD; e-mail, [email protected]edu.This article was published at Annals.org on 29 April 2022. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics June 2022Volume 175, Issue 6Page: SS1 ePublished: 29 April 2022 Issue Published: June 2022 CopyrightCopyright © 2022 by American College of Physicians. All Rights Reserved.Loading ...
Global, distinctive, and personal changes in molecular and microbial profiles by specific fibers in humans
Authors: Samuel M. Lancaster, Brittany Lee-McMullen, Charles Wilbur Abbott, Jeniffer V. Quijada, Daniel Hornburg, Heyjun Park, Dalia Perelman, Dylan J. Peterson, Michael Tang, Aaron Robinson, Sara Ahadi, Kévin Contrepois, Chia-Jui Hung, Melanie Ashland, Tracey McLaughlin, Anna Boonyanit, Aaron Horning, Justin L. Sonnenburg, Michael P. Snyder
Journal: Cell Host & Microbe (2022)

Dietary fibers act through the microbiome to improve cardiovascular health and prevent metabolic disorders and cancer. To understand the health benefits of dietary fiber supplementation, we investigated two popular purified fibers, arabinoxylan (AX) and long-chain inulin (LCI), and a mixture of five fibers. We present multiomic signatures of metabolomics, lipidomics, proteomics, metagenomics, a cytokine panel, and clinical measurements on healthy and insulin-resistant participants. Each fiber is associated with fiber-dependent biochemical and microbial responses. AX consumption associates with a significant reduction in LDL and an increase in bile acids, contributing to its observed cholesterol reduction. LCI is associated with an increase in Bifidobacterium. However, at the highest LCI dose, there is increased inflammation and elevation in the liver enzyme alanine aminotransferase. This study yields insights into the effects of fiber supplementation and the mechanisms behind fiber-induced cholesterol reduction, and it shows effects of individual, purified fibers on the microbiome.
Nivolumab after sorafenib failure in liver recipients with HCC recurrence
Authors: Ji Eun Kwon, Jaehun Yang, Manuel Lim, Eun Sung Jeong, Kyeong Deok Kim, Jinsoo Rhu, Gyu-Seong Choi, Jae-Won Joh, Jong Man Kim
Journal: International Journal of Surgery (2022)