tbuckley/cabot-search huggingface dataset:
Does interruption of imatinib (IM) in responding GIST patients after one year of treatment influence the secondary resistance to IM after its reintroduction? Updated results of the prospective French Sarcoma Group randomized phase III trial on long term survival
Authors: D. Pérol, J. Dômont, I. L. Ray-Coquard, B. N. Bui, M. Rios, F. Duffaud, F. Bertucci, C. Moneron, S. Chabaud, A. Le Cesne, J. Y. Blay
Journal: Journal of Clinical Oncology (2008)

10556 Background: IM must not be interrupted after one year (yr) in responding patients (pts) (JCO 2007). The impact of IM re-introduction at progression (PD) remains unknown on the duration of GIST tumor cells sensitivity. Methods: After 1 yr of IM 400mg/d, 58 pts free from progression were randomly offered to continue (C arm, 26 pts) or interrupt IM (I arm, 32 pts) until PD. Twenty-nine pts (91%) allocated to the I arm restart IM (same dose) after first PD. Time to progression was analyzed between randomization and first PD in the C arm and second PD in the I arm. Results: After a median follow-up after randomization of 41 months, there were 18 1st and 15 2nd PD in the C and I arm, respectively. The median PFS were 28 months and 26 months in the C and I arm, respectively (p=0.82). OS rates were 92% and 87% for arms C and I, respectively (p=0.78). On the 3 pts allocated in the I arm not relapsing to date, one refused to stop IM, one had a locally advanced GIST operated before randomization in the I arm and one had a metastatic GIST. Conclusions: Despite a significant increase of PD in the I arm, IM re-introduction at the same dose allows a tumor control in the majority of pts. Time to secondary resistance to IM is similar in the two therapeutic arms. IM interruption seems to have no impact on the sensitivity/resistance of GIST tumor cells. These findings could have an impact in the therapeutic approaches after a relapse in pts receiving IM in an adjuvant setting. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration GlaxoSmithKline, Novartis, Pfizer Oncology, PharmaMar, Roche GlaxoSmithKline, Novartis, Pfizer Oncology, PharmaMar, Roche Novartis, Pfizer Oncology
Plasma Lipoprotein Induction and Suppression of the Generation of Cellular Procoagulant Activity in Vitro
Authors: Gary A. Levy, Bradford S. Schwartz, Linda K. Curtiss, Thomas S. Edgington
Journal: Journal of Clinical Investigation (1981)

Isolated human plasma very low density, intermediate density, and high density lipo-proteins at physiologic concentrations have been demonstrated in the preceding report to induce significant increases in the procoagulant activity of human peripheral blood mononuclear cells in vitro, whereas low density lipoprotein did not. The monocyte was identified in this study by cellular fractionation and by direct cytologic assays as the source of this inducible activity, thus identifying the procoagulant activity as a monokine. The generation of these lipoprotein-induced procoagulant monokines was entirely dependent upon the presence of lymphocytes. Isolated lymphocytes that had been exposed to the stimulatory lipoproteins could induce monocytes to produce the procoagulant activity, whereas neither the culture medium from lipoprotein-stimulated lymphocytes, homogenates of lymphocytes, nor other cells such as platelets could substitute for this requirement. The interaction of the stimulatory lipoproteins with lymphocytes was rapid, reaching completion within 30 min, and was equally effective at either 4° or 37°C. Low density lipoprotein did not stimulate lymphocytes to induce monocyte procoagulant activity, but did actively suppress the production of the procoagulant monokines induced by each of the stimulatory lipoproteins, as well as bacterial lipopolysaccharide. The monocyte was identified as the cell sensitive to low density lipoprotein suppression, and no suppression of lymphocyte triggering was observed. These observations on the interaction of plasma lipoproteins with lymphocytes and monocytes in vitro introduce two new regulatory events by which plasma lipoproteins influence the function of cells, and define a regulatory network by which certain lipoprotein classes trigger lymphocytes, which can in turn induce monocytes to express procoagulant activity. Only this latter phase is subject to lipoprotein suppression by physiologic concentrations of low density lipoprotein.
Use of the Structured Clinical Interview for DSM-IV Dissociative Disorders for systematic assessment of dissociative symptoms in posttraumatic stress disorder
Authors: J D Bremner, M Steinberg, S M Southwick, D R Johnson, D S Charney
Journal: American Journal of Psychiatry (1993)

This study compared dissociative symptom areas in Vietnam combat veterans with posttraumatic stress disorder (PTSD) and in Vietnam combat veterans without PTSD.The Structured Clinical Interview for DSM-IV Dissociative Disorders (SCID-D) was used to compare dissociative symptoms in 40 Vietnam combat veterans with PTSD and 15 Vietnam combat veterans without PTSD. The SCID-D yields a total score and scores in five symptom areas: amnesia, depersonalization, derealization, identity confusion, and identity alteration.The PTSD patients had more severe dissociative symptoms in each of the five symptom areas of the SCID-D and higher total symptom scores. Amnesia was the symptom area with the greatest difference in scores between the PTSD patients (mean = 3.68, SD = 0.73) and the non-PTSD veterans (mean = 1.06, SD = 0.26).The finding of higher levels of dissociative symptoms in Vietnam combat veterans with PTSD than in Vietnam veterans without PTSD is consistent with a level of dissociative symptoms in PTSD similar to that in dissociative disorders.
Abstract MP25: Dietary Fat Intake, Mc4r Genotype and 2-Year Changes in Body Composition: The Pounds Lost Trial
Authors: Tao Huang, Yiru Shen, Yan Zheng, Steven Smith, George Bray, Frank Sacks, Lu Qi
Journal: Circulation (2015)

Background:  Melanocortin receptor 4 (MC4R) is a key protein regulating dietary intake and adiposity in humans. MC4R gene variants have been associated with fat intake, fat mass, weight change, and risk of obesity. Observational studies have suggested that dietary fat may modify these effects; however, this has yet to be verified in long-term randomized clinical trials.   Objective:  To examine the interaction between an “obesity-predisposing” MC4R variant and fat intake on long-term changes in body composition in the context of a randomized controlled trial.   Design and Methods:  We genotyped MC4R rs17782313 and assessed body composition in 373 overweight adults in the 2-year Preventing Overweight Using Novel Dietary Strategies (Pounds Lost) trial.   Results:  We found significant interactions between the MC4R rs17782313 and dietary fat intake on changes in lean mass and total mass at 6 months (p for interaction=0.019 and 0.012, respectively) after adjusting for age, sex, ethnicity, baseline BMI, 6 months weight loss, and baseline perspective outcomes. The C allele was significantly associated with a greater increase in lean mass and total mass in the low-fat diet group (P=0.008 and 0.005, respectively), but not associated with these measures in the high-fat diet group at 6 months (P>0.05, respectively) (Figure 1). We didn’t observe significant genotype-diet interaction on changes in body compositions at 24 months, probably due to regain of body weight after 6 months.   Conclusions:  Our data suggest that individuals with the MC4R rs17782313 C allele might experience greater increases in lean mass and total mass when consuming a lower fat weight-loss diet.   Keywords:  MC4R genotype, body composition, gene-diet interaction, weight-loss trial
Abstract 13601: The Association of AHA Ideal Cardiovascular Health with Cancer Incidence: The ARIC Study
Authors: Laura J Rasmussen-Torvik, Christina M Shay, Judith Abramson, Jennifer A Nettleton, Christopher A Friedrich, Anna E Prizment, Aaron F Folsom
Journal: Circulation (2011)

In the Strategic 2020 Goals, the AHA defined ideal cardiovascular (CV) health based on 7 CVD risk factors and behaviors. Many of these metrics have also been associated with cancer incidence. We sought to examine the association between number of ideal CV health metrics and cancer incidence in the Atherosclerosis Risk in Communities (ARIC) study, a community-based cohort. Methods: Participants reporting no history of cancer at baseline with complete data for classification of all seven ideal health metrics were included (n= 13360). Data from the baseline exam (1987-1989) was used to determine whether each participant met the definition of ideal health for each of the metrics (smoking, BMI, physical activity, diet, cholesterol, blood pressure, and serum fasting glucose). The total number of ideal health metrics per person was summed for analysis. Incidence of breast, colorectal, lung, and prostate cancers 1987-2006 were obtained through linkage to cancer registries. Adjusted combined cancer incidence rates...
Treatise on Orthopedic Surgery.
Authors: Edward H. Bradford, Robert W. Lovett
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prospective Karyotype Analysis in Adult Acute Lymphoblastic Leukemia: The Cancer and Leukemia Group B Experience
Authors: Meir Wetzler, Richard K. Dodge, Krzysztof Mrózek, Andrew J. Carroll, Ramana Tantravahi, AnneMarie W. Block, Mark J. Pettenati, Michelle M. Le Beau, Stanley R. Frankel, Carleton C. Stewart, Ted P. Szatrowski, Charles A. Schiffer, Richard A. Larson, Clara D. Bloomfield
Journal: Blood (1999)
Quality control assessment of influenza and RSV testing in Europe: 2000-01 season
Authors: M Valette, M Aymard
Journal: Eurosurveillance (2002)

The Quality Control Assessment (QCA) was initiated to evaluate the quality of the influenza and respiratory syncytial virus (RSV) testing in the national reference centres belonging to the European Influenza Surveillance Scheme (EISS) network. Samples were coded and sent in two panels of 12 samples within a two week interval to 16 laboratories during the 2000-01 winter season. The antibodies titration by HI test was reported by 60% of the laboratories (n=16), and the results were correct for 56% of them. One false detection of influenza B antibodies was reported by one laboratory, and for the others the sensitivity varied widely. The sensitivity of the tests for the detection of influenza virus varied for A(H3N2) from 10 to 100 000 TCID50/ml. The influenza A subtyping was performed by 87% of the laboratories, and 31% gave correct results. The characterisation of the variants was undertaken by six laboratories and half of them fully achieved it. Fifty six percent of the laboratories used RT-PCR for the diagnosis; the results were specific and the sensitivity equivalent to the cell culture.
SOME NOTES ON CYSTIC DISEASE OF THE LUNGS, WITH A REPORT OF ONE CASE
Authors: W. Raney Stanford, Brodie C. Nalle
Journal: Annals of Internal Medicine (1942)

Article1 July 1942SOME NOTES ON CYSTIC DISEASE OF THE LUNGS, WITH A REPORT OF ONE CASEW. RANEY STANFORD, M.D., F.A.C.P., BRODIE C. NALLE JR., M.D.W. RANEY STANFORD, M.D., F.A.C.P., BRODIE C. NALLE JR., M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-17-1-65 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn a case of multiple cyst-formation in the lung,...Bibliography1. SCHENCK SG: Diagnosis of congenital cystic disease of the lung, Arch. Int. Med., 1937, lx, 1-21. CrossrefGoogle Scholar2. FORD FA: Congenital cystic disease of the lung in new-born infant, Radiology, 1938, xxx, 248-249. CrossrefGoogle Scholar3. KINGHARRIS JCLC: Congenital lung cyst, Jr. Am. Med. Assoc., 1937, cviii, 274-280. CrossrefGoogle Scholar4. WOOD HG: Congenital cystic disease of lungs, Jr. Am. Med. Assoc., 1934, ciii, 815-821. CrossrefGoogle Scholar5. COLENALLS DBWC: Congenital cystic lung disease, Jr. Lab. and Clin. Med., 1938, xxiii, 1111-1116. Google Scholar6. KOONTZ AR: Congenital cysts of the lung, Bull. Johns Hopkins Hosp., 1925, xxxvii, 340-346. Google Scholar7. ANDERSON WW: Congenital lung cysts, air-expansile types, South. Med. Jr., 1938, xxxi, 628-632. CrossrefGoogle Scholar8. GORDAN I: Benign spontaneous pneumothorax, Lancet, 1936, ii, 178-181. CrossrefGoogle Scholar9. WOOD HG: Congenital cystic disease of the lung, Jr. Thoracic Surg., 1937, vi, 634-637. CrossrefGoogle Scholar10. KIRKLIN BR: Congenital cysts of the lung from the roentgenological viewpoint, Am. Jr. Roentgenol., 1936, xxxvi, 19-29. Google Scholar11. FREEDMAN E: Congenital cysts of the lungs, Am. Jr. Roentgenol., 1936, xxxv, 44-52. Google Scholar12. PEARSON EF: Non-parasitic cystic disease of lung; its clinical recognition and treatment, Jr. Thoracic Surg., 1934, iv, 84-100. CrossrefGoogle Scholar13. PIERCEDIRKSE CBPR: Pulmonary pneumatocele (localized alveolar or lobular ectasia), Radiology, 1937, xxviii, 651-667. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication March 26, 1940. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySURGICAL TREATMENT OF CONGENITAL CYSTIC DISEASE OF THE LUNG WITH A REPORT OF TWO CASESMultiple pulmonary artery aneurysmsCongenital lung cyst complicated by pyopneumothorax 1 July 1942Volume 17, Issue 1Page: 65-77KeywordsBlistersEmphysemaLungsShoulders Issue Published: 1 July 1942 PDF downloadLoading ...
Lang's German-English Dictionary of Terms Used in Medicine and the Allied Sciences With Their Pronunciation.
Authors: Hugo Lang, Milton Kayton Meyers
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Optimizing ribavirin dose is critical for sustained viral response in patients with thalassemia major treated for chronic hepatitis C
Authors: Paul J. Clark, Rosanna Santoro, Valeria Piazzolla, Leonardo Mottola, D. Bacca, N. Dello Iacono, Salvatore Grimaldi, Antonella Quarta, Thomas J. Urban, Susanna Naggie, Keyur Patel, Alexander J. Thompson, Andrew J. Muir, Alessandra Mangia
Journal: Hepatology (2012)
Comparison of Transcatheter and Surgical Aortic Valve Replacement in Severe Aortic Stenosis
Authors: Rebecca T. Hahn, Philippe Pibarot, William J. Stewart, Neil J. Weissman, Deepika Gopalakrishnan, Martin G. Keane, Saif Anwaruddin, Zuyue Wang, Martin Bilsker, Brian R. Lindman, Howard C. Herrmann, Susheel K. Kodali, Raj Makkar, Vinod H. Thourani, Lars G. Svensson, Jodi J. Akin, William N. Anderson, Martin B. Leon, Pamela S. Douglas
Journal: Journal of the American College of Cardiology (2013)
Biological Antioxidants: Transactions of the Fifth Conference November 30-December 1, 1950, New York, N. Y.
Authors: Cosmo G. Mackenzie
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1667: Angiotensin II and Free Cholesterol Synergistically Impaired eNOS Bioavailability via Lipid Raft
Authors: Eisuke Amiya, Koji Maemura, Norihiko Takeda, Tetsuya Saito, Taro Shiga, Yumiko Hosoya, Tomoko Nakao, Yasushi Imai, Ryozo Nagai
Journal: Circulation (2008)

Both hypercholesterolemia and angiotensin II (Ang II) are potent factors inducing endothelial dysfunction that leads to atherosclerosis. It has been reported that coexistence of hypercho-lesterolemia and Ang II accelerates atherogenesis markedly. Several studies showed that elevated cellular cholesterol affected cellular function by modifying lipid raft. We investigated the contribution of lipid raft to bridging hypercholesterolemia and Ang II in endothelial cells. Free cholesterol (Chol) loading induced 2–3 fold increase in cellular cholesterol content. Co-treatment of Ang II and Chol markedly impaired eNOS phosphorylation and dimerization than Chol or Ang II loading alone. This inactivation of eNOS corresponded to eNOS translocation to Chol-rich fractions in density centrifugation. In this fraction, eNOS phosphorylation and dimerization were markedly suppressed. Olmesartan or ROS inhibitor suppressed this eNOS trafficking and reversed the impairment of eNOS bioavailability. In immunohistochemistry, the target of this eNOS trafficking was identified as Chol-rich vesicle structure at the perinuclear area and those were fused with lysosomal membrane associated protein-1 (LAMP-1), a lysosome marker, labeled endosome. These results suggested that in cholesterol enriched condition, AngII induced eNOS trafficking to Chol-rich vesicles that were fused with lysosome at the perinuclear area and keeps eNOS inactive. We next investigated the association between these Chol-rich vesicles and lipid raft. GM1, phospho-caveilin1 and Rac, which are all lipid raft actors, also shifted to Chol-rich fractions in density centrifugation and assembled at LAMP-1 labeled endosome at the perinuclear area after Ang II and Chol loading. Therefore, LAMP-1 labeled endosome was considered to be the intracellular target of lipid raft in that condition. In electron microscopy, Chol-rich vesicles corresponded to multivesicular bodies and these converged to lysosome with Ang II addition, which were consistent with immunohistochemical findings. These studies show the important crosstalk between AngII and Chol signaling leading to endothelial dysfunction and provide a novel insight into the mechanisms of endothelial dysfunction by hypercholesterolemia.
New England Essays: The Challenge of an Individualist.
Authors: Edward Henry Packard
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nasogastric Intubation
Authors: Todd W. Thomsen, Robert W. Shaffer, Gary S. Setnik
Journal: New England Journal of Medicine (2006)

Common indications for nasogastric intubation include decompression of the GI tract in patients with bowel obstruction and gastric emptying in intubated patients to prevent aspiration. NG tubes may be placed as an adjunct for the delivery of oral agents, such as activated charcoal or oral radiographic contrast medium. NG tubes are often placed in patients with suspected upper GI hemorrhage. However, the sensitivity and negative predictive value of nasogastric aspirates for detecting active bleeding is suboptimal, and the absence of bloody return cannot be relied upon to rule out hemorrhage. Nonetheless, nasogastric intubation may be useful in selected patients. Evacuation . . . .
Numbers are small
Authors: D Bhugra, J Leff, R Mallett
Journal: BMJ (1995)

absolute difference between the rates is almost similar in both cases.Our main comment, however, relates to Frisoni and colleagues' concluding comments.Although we agree that prospective studies are needed, we do not agree that the epidemiological relevance of e4 in determining Alzheimer's disease may be lower than suggested by others.This is certainly plausible.Although we have no extensive clinical data on Alzheimer's disease available in our cohort, the proportion of men with the disease in our population based sample of elderly men was probably very low.Since despite this low propor- tion e4 predicts cognitive decline, the role of e4 in dementia and disorders related to dementia in general might instead be larger than expected.