tbuckley/cabot-search huggingface dataset:
Use of the Janssen (Johnson &amp; Johnson) COVID-19 Vaccine: Updated Interim Recommendations from the Advisory Committee on Immunization Practices — United States, December 2021
Authors: Sara E. Oliver, Megan Wallace, Isaac See, Sarah Mbaeyi, Monica Godfrey, Stephen C. Hadler, Tara C. Jatlaoui, Evelyn Twentyman, Michelle M. Hughes, Agam K. Rao, Anthony Fiore, John R. Su, Karen R. Broder, Tom Shimabukuro, Allison Lale, David K. Shay, Lauri E. Markowitz, Melinda Wharton, Beth P. Bell, Oliver Brooks, Veronica McNally, Grace M. Lee, H. Keipp Talbot, Matthew F. Daley
Journal: MMWR Morbidity and Mortality Weekly Report (2022)

On February 27, 2021, the Food and Drug Administration (FDA) issued an Emergency Use Authorization (EUA) for the adenovirus-vectored COVID-19 vaccine (Janssen Biotech, Inc., a Janssen Pharmaceutical company, Johnson & Johnson), and on February 28, 2021, the Advisory Committee on Immunization Practices (ACIP) issued an interim recommendation for its use as a single-dose primary vaccination in persons aged ≥18 years (1,2). On April 13, 2021, CDC and FDA recommended a pause in the use of Janssen COVID-19 vaccine after reports of thrombosis with thrombocytopenia syndrome (TTS), a rare condition characterized by low platelets and thrombosis, including at unusual sites such as the cerebral venous sinus (cerebral venous sinus thrombosis [CVST]), after receipt of the vaccine.* ACIP rapidly convened two emergency meetings to review reported cases of TTS, and 10 days after the pause commenced, ACIP reaffirmed its interim recommendation for use of the Janssen COVID-19 vaccine in persons aged ≥18 years, but included a warning regarding rare clotting events after vaccination, primarily among women aged 18-49 years (3). In July, after review of an updated benefit-risk assessment accounting for risks of Guillain-Barré syndrome (GBS) and TTS, ACIP concluded that benefits of vaccination with Janssen COVID-19 vaccine outweighed risks. Through ongoing safety surveillance and review of reports from the Vaccine Adverse Event Reporting System (VAERS), additional cases of TTS after receipt of Janssen COVID-19 vaccine, including deaths, were identified. On December 16, 2021, ACIP held an emergency meeting to review updated data on TTS and an updated benefit-risk assessment. At that meeting, ACIP made a recommendation for preferential use of mRNA COVID-19 vaccines over the Janssen COVID-19 vaccine, including both primary and booster doses administered to prevent COVID-19, for all persons aged ≥18 years. The Janssen COVID-19 vaccine may be considered in some situations, including for persons with a contraindication to receipt of mRNA COVID-19 vaccines.
DOMESTIC CORRESPONDENCE.
Authors: J. M. Batten
Journal: JAMA (1885)

teresting to notice that, although a pin might be run through the flesh without pain, yet within the blister the least touch produced the greatest agony.I saw the patient on January 23, 1885.She came into Dr.Landau's office leaning upon a crutch, and wheezing like a person with an attack of asthma.Her respira¬ tion was rapid and shallow, her speech jerky, and there was well-marked aphonia.When she tried to speak she brought on asevere fit of coughing.Press¬ ure over the left ovarian region was attended with no symptoms whatever.Pressure over the right ovary set up a modified convulsive spasm, and the pa¬ tient complained of much pain, although Dr. Landau said that the ovary was gradually becoming less sensitive.Pressure over the liver was attended with
Relation between left ventricular sphericity and errors in M-mode mass: Insights from magnetic resonance imaging Michael L. Chuang, Carol J. Salton, Kraig V. Kissinger, Daniel Levy, Christopher J. O'Donnell, Warren J. Manning. Beth Israel Deaconess Medical Center, Boston, MA, The NHLBI's Framingham Heart Study, Framingham, MA
Journal: Journal of the American College of Cardiology (2001)
SARS-CoV-2 Initiates Programmed Cell Death in Platelets
Authors: Milka Koupenova, Heather A. Corkrey, Olga Vitseva, Kahraman Tanriverdi, Mohan Somasundaran, Ping Liu, Shaukat Soofi, Rohan Bhandari, Matthew Godwin, Krishna Mohan Parsi, Alyssa Cousineau, René Maehr, Jennifer P. Wang, Scott J. Cameron, Jeffrey Rade, Robert W. Finberg, Jane E. Freedman
Journal: Circulation Research (2021)

Rationale: Coronavirus disease 2019 (COVID-19) is characterized by increased incidence of microthrombosis with hyperactive platelets sporadically containing viral RNA. It is unclear if SARS-CoV-2 (severe acute respiratory syndrome, corona virus-2) directly alters platelet activation or if these changes are a reaction to infection-mediated global inflammatory alterations. Importantly, the direct effect of SARS-CoV-2 on platelets has yet to be studied. Objective: To characterize the direct SARS-CoV-2–platelet interactions using in vitro studies with purified infectious virions and samples from infected patients. Methods and Results: Platelet RNA analyzed by ARTIC v3 sequencing for SARS-CoV-2 showed presence of fragmented viral genome in all patients with COVID-19. Immunofluorescent imaging of platelets from patients with COVID-19 confirmed presence of SARS-CoV-2 proteins, whereas there was no detection of viral RNA by real-time quantitative polymerase chain reaction. Transmission electron microscopy of platelets incubated with purified SARS-CoV-2 virions demonstrated rapid internalization and digestion leading to distinct morphological changes and resulted in a release of extracellular vesicles. Interactions between SARS-CoV-2 and platelets occurred with or without ACE (angiotensin-converting enzyme) 2 presence as measured by immunofluorescence. Transmission electron microscopy showed that SARS-CoV-2 virions became internalized when they were attached to microparticles, bypassing the need for ACE2. Enrichment analysis of platelet transcriptome from patients with acute COVID-19, compared with those with clinical thrombosis, suggested upregulation of pathways related to virally mediated cell death, specifically necroptosis and apoptosis. Platelets incubated with infectious virus appeared to undergo cell death in 30 minutes postincubation as assessed by transmission electron microscopy and platelets from patients with COVID-19 showed evidence of increased markers of apoptosis and necroptosis by Western blot. Immunofluorescence confirmed colocalization of SARS-CoV-2 with phospho-MLKL (mixed lineage kinase domain-like pseudokinase) and caspase 3 on nonpermeabilized platelets in vitro and in COVID-19 platelets. Conclusions: Platelets internalize SARS-CoV-2 virions, directly or attached to microparticles, and viral internalization leads to rapid digestion, programmed cell death, and extracellular vesicle release. During COVID-19, platelets mediate a rapid response to SARS-CoV-2 and this response can contribute to dysregulated immunity and thrombosis.
Genomic landscape of TCRαβ and TCRγδ T-large granular lymphocyte leukemia
Authors: HeeJin Cheon, Jeffrey C. Xing, Katharine B. Moosic, Johnson Ung, Vivian W. Chan, David S. Chung, Mariella F. Toro, Omar Elghawy, John S. Wang, Cait E. Hamele, Ross C. Hardison, Thomas L. Olson, Su-Fern Tan, David J. Feith, Aakrosh Ratan, Thomas P. Loughran
Journal: Blood (2022)
Summaries of Key Journal Articles
Authors: Kim A. Eagle, Christopher P. Cannon, William F. Armstrong, David S. Bach, Ragavendra R. Baliga, Anna M. Booher, Timothy B. Cotts, Jennifer Cowger, Daniel T. Eitzman, James B. Froehlich, Caren S. Goldberg, Hitinder S. Gurm, Jennifer C. Hirsch, Elizabeth Anne Jackson, Fred Morady, Debabrata Mukherjee, Himanshu J. Patel, John E. Rectenwald, Melvyn Rubenfire
Journal: Journal of the American College of Cardiology (2010)
Is 2045 Optimistic?—Concerns Regarding Rising Vaccine Hesitancy
Authors: Erich M. Sturgis, Malgorzata K. Nowakowska, Jay K. Ferrell
Journal: JAMA Oncology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Abstract 38: Glucose Levels and Brain Gray Matter Volume in Middle-aged Adults: Findings From the Coronary Artery Risk Development in Young Adults CARDIA Study
Authors: Martine Elbejjani, R Nick Bryan, Pamela J Schreiner, David R Jacobs, Cora E Lewis, Stephen Sidney, Jared Reis, Ju-Mi Lee, Lenore J Launer
Journal: Circulation (2017)

Background: Type II diabetes has been widely linked to a higher risk of dementia. Some studies have also shown relationships between diabetes and magnetic resonance imaging (MRI) markers of exacerbated brain aging and neurocognitive pathology, such as gray matter (GM) volume atrophy. However, data on the earlier impacts of glucose levels on GM volume in younger subjects are scarce. Objective: We assessed the cross-sectional relationship of fasting glucose levels and GM volume measured at middle-age. Methods: Data come from the brain MRI sample of the CARDIA study, a bi-racial community-dwelling cohort of middle-aged adults (n=709, mean age=50 (SD=3.5)). We used multivariable linear regression models and adjusted for potential confounders, including several cardiovascular and metabolic factors (hypertension, body mass index, smoking, history of vascular disease, and hypercholesterolemia). Results: Higher fasting glucose levels were associated with smaller total GM volume (-1 mL (95%CI= -0.16, -0.04) smaller GM volume per each 1 mg/dL increase in glucose levels). In analyses exploring the normal (&lt;100 mg/dL), pre-diabetic (≥100, &lt;126 mg/dL), and diabetic glucose ranges (≥126 mg/dL), we found that subjects with diabetic glucose levels had -14 mL smaller GM (95%CI= -21.50, -5.61; p=0.001) than subjects with normal glucose levels; subjects with pre-diabetic levels were not significantly different from those with normal levels (p for trend for the glucose-range categories =0.08). Conclusion: Results suggest that important relationships between glucose levels and smaller GM can already be detected at middle-age. These associations were particularly pronounced in the diabetic glucose ranges. Findings strengthen the links between vascular factors and brain health and emphasize the importance of studying the earlier stages of these links to improve our understanding of the course of brain diseases and to identify optimal time-windows for prevention and treatment strategies.
Letter to the editor: Relevance of population‐based cutoffs to define frailty in clinical studies
Authors: Shweta A. Singh, Kaushal Madan, Subhash Gupta, Abhaya Indrayan
Journal: Hepatology (2022)

To the editor, We read with interest the article by Wang et al.,[1] where they demonstrated that frailty among patients with cirrhosis, defined by liver frailty index (LFI) > 4.5, was associated with progression of cirrhosis or death and risk of unplanned hospitalization independent of age, gender, and Model for End‐Stage Liver Disease score. Of their 822 patients with cirrhosis, 14.1% (n = 116) were from India (non‐Caucasians). The prevalence of frailty in their Asian cohort (including 116 Indians) was only 29.9%, which was much lower than the corresponding prevalence of 62.2% in the Caucasian cohort. We believe that this discrepancy occurred because they applied Western cutoffs, which would have underestimated the prevalence of frailty in the Indian subjects and may have impacted the prediction of outcomes studied. It is understood, and the authors themselves acknowledge, that nutritional parameters which are used to derive LFI are dependent on the ethnicity of the population studied.[2,3] Further, the LFI cutoffs used in the study were not gender‐specific, again underestimating the prevalence of frailty among female subjects. We have derived cutoffs for handgrip strength (HGS), chair stand‐up test (CSUT) and LFI from 514 healthy Indian adults (272 male and 242 female), comprising 242 healthy liver donors and 272 healthy health care workers from our institute. The cutoff for HGS was taken as the 5th percentile and that of CSUT and LFI was the 95th percentile. Our LFI cutoffs of 3.49 and 3.68 for male and female patients, respectively, are considerably lower than the single cutoff of 4.5 used by Wang et al. When we applied the gender‐specific LFI cutoffs derived by us to our patients with cirrhosis scheduled to undergo liver transplantation, the prevalence of frailty was 59.45%. Hence, application of ethnically appropriate, population‐specific, and gender‐specific cutoffs is essential to define frailty among patients with cirrhosis. CONFLICT OF INTEREST Nothing to report.
EDITORIAL NOTE
Authors: None Sulphaqua
Journal: British Journal of Dermatology (1898)

GURRENT LITERATURE.bodies, scattered or in groups, resembling the spores of trichophyta.The second case was B child, 9 years old, with a patch of tinea the size of a five-frano piece on the right forearm, on which was situated a nodulated elongated elevation, crescentic in shape, covered with red, tense, unbroken skin.This nodule was open and showed deep infiltration of the skin, and beside it were two or three small separate pustules.A younger brother of the patient was also the subject
Lettsomian Lectures on Midwifery and Diseases of Women
Authors: C. H. F. Routh
Journal: BMJ (1864)

THE UTERUS.Causes of Uterine Tutmours.FROM what we have already seen, it can scarcely be doubted that in pregnant women the fibrous tumour, which grows with the uterine organ itself, essentially partakes of its muscular elements; also, that in an unimpregnated but hypertrophied uterus, the same structures may be found.The point is
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Authors: Simone Birnbaum, Raphaël Porcher, Tarek Sharshar
Journal: JAMA Neurology (2021)

neurologists treating patients with MG.According to a recent systematic review, 2 there is insufficient evidence to conclude that high-dose corticotherapy increases exacerbation in MG.Furthermore, our study 1 demonstrated that high-dose corticosteroids can be prescribed in MG without significant deterioration.With respect to the second point raised by Akamine et al, we did not evaluate quality of life.At the time our protocol was designed, the French version of the 15-item Myasthenia Gravis Quality of Life Scale 3 was not yet available.To evaluate the functional outcomes of MG, we used the Myasthenia Gravis Activities Of Daily Living score, which was slightly higher in the rapid-tapering arm (means [SDs], 1.5 [2.2] vs 1.1 [2.6]) at 12 months.However, we do not believe this to be clinically meaningful.The tapering of corticotherapy in both groups achieved MG stability that was comparable at 12 and 15 months; however, our study 1 demonstrates that this can be obtained with smaller doses of corticosteroids (per our Table 2), as highlighted by Akamine et al.As also pointed out by Akamine et al, reducing the cumulative dose of corticosteroids, when possible, is preferable for individuals with MG.
Deep cfDNA fragment end profiling enables cancer detection
Authors: Yulia V. Zhitnyuk, Anastasia P. Koval, Aleksandr A. Alferov, Yanina A. Shtykova, Ilgar Z. Mamedov, Nikolay E. Kushlinskii, Dmitriy M. Chudakov, Dmitry S. Shcherbo
Journal: Molecular Cancer (2022)
Correlation between myocardial video-intensity and velocity gradients assessed by myocardial contrast echocardiography and tissue doppler imaging in a porcine model of non-transmural myocardial infarction Philippe Garot, Olivier Pascal, Marc Simon, Saleh el Amine, Sophie Benacerraf, Jean-Luc Dubois-Rand�, Luc Hittin er, Emmanuel Teiger, Pascal Gu�ret. Hopital Henri Mondor, Creteil, France
Journal: Journal of the American College of Cardiology (2001)
Cholecystectomy 7 days vs 4 weeks after mild biliary pancreatitis; looking a decrease the incidence of persistent choledocholithiasis and ERCP: A multicentric randomized clinical trial
Authors: Helena Gómez Facundo, Ruth Ribas Montoliu, Daniel Rolando Coronado Llanos, Gemma Sugranyes Naval, Erik Llàcer Millán, Sandra López Gordo, Judith Hermoso Bosch, Sergio López Rodríguez, Montse Martín Baranera, Sergio González Martínez
Journal: International Journal of Surgery (2022)
Therapeutic Application of Alpha-1 Antitrypsin in COVID-19
Authors: Felix Ritzmann, Praneeth Chitirala, Nadine Krüger, Markus Hoffmann, Wei Zuo, Frank Lammert, Sigrun Smola, Naveh Tov, Noga Alagem, Philipp M. Lepper, Stefan Pöhlmann, Christoph Beisswenger, Christian Herr, Robert Bals, Yiwen Yao, Nastasja Seiwert, Guy Danziger
Journal: American Journal of Respiratory and Critical Care Medicine (2021)

To the Editor:Coronavirus disease (COVID-19) is a novel illness and is a rapidly evolving pandemic with unprecedented impact on global health in the last 100 years (1).At the time of submission of this work, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused 130 million diagnosed infections and 2.8 million known deaths.Although vaccines are currently developed and are now broadly used in public health prevention measures, the treatment options for patients with COVID-19 are sparse and do not show sufficient efficacy (2).SARS-CoV-2 uses several host factors to infect target cells, including TMPRSS2 (transmembrane protease serine 2), for activation of the viral
A prospective cross-sectional study estimated glomerular filtration rate from creatinine and cystatin C in adults with solid tumors
Authors: Verônica T. Costa e Silva, Luiz A. Gil, Lesley A. Inker, Renato A. Caires, Elerson Costalonga, George Coura-Filho, Marcelo T. Sapienza, Gilberto Castro, Maria DP. Estevez-Diz, Dirce Maria T. Zanetta, Leila Antonângelo, Lia Marçal, Hocine Tighiouart, Shiyuan Miao, Paul Mathew, Andrew S. Levey, Emmanuel A. Burdmann
Journal: Kidney International (2022)
From the NIH: Cyclophosphamide may be effective in severe vasculitis
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A global index of cardiac autonomic status and reflexes Azad Ghuran, Fiona Reid, Irina Savelieva, Maria Teresa La Rovere, Georg Schmidt, J. Thomas Bigger, Jr., A John Camm, Peter J Schwartz, Marek Malik. St. George's Hospital Medical School, London, United Kingdom, Department of Cardiology, Policlinico S. Matteo IRCCS and University of Pavia, Pavia, Italy
Journal: Journal of the American College of Cardiology (2001)
Abstract 418: Genetic Rescue of Connexin 43 Remodeling in Muscular Dystrophy Cardiomyopathy
Authors: Eric Himelman, Jorge E Contreras, Natalia Shirokova, Diego Fraidenraich
Journal: Circulation Research (2017)

Dilated cardiomyopathy has emerged as a major cause of lethality in Duchenne Muscular Dystrophy (DMD). Despite the growing influence on mortality, studies of dystrophic cardiomyopathy remain limited. We have found key evidence suggesting that aberrant expression of Connexin 43 (Cx43), a critical component of cardiomyocyte gap junctions, plays a detrimental role in DMD-cardiomyopathy. We showed Cx43 protein upregulation and lateralization away from the intercalated discs (IDs) to the lateral sarcolemma borders in both mouse (mdx) and human DMD cardiac tissues. Selective inhibition of the function of lateralized Cx43 protected Isoproterenol (Iso) challenged mdx mice from severe arrhythmias. We determined that Cx43 in mdx hearts is hypo-phosphorylated in a specific triplet of serine residues (S325/S328/S330). Reduction of phosphorylation in this same triplet promotes Cx43 lateralization and has been directly linked to cardiac ischemia, hypertrophy and arrhythmias. To investigate the role of the serine-triplet toward Cx43 remodeling and DMD cardiac pathology, we generated knock-in mutant mdx mice where the serine-triplet was modified to either non-phosphorylatable alanine (mdx:S3A) or phospho-mimetic glutamic acid residues (mdx:S3E). The changes in Cx43 phosphorylation status were confirmed by immunoblotting wherein mdx:S3E cardiac extracts prominently display slowly-migrating phosphorylated Cx43 bands while mdx:S3A extracts display a faster migrating isoform. We observed that 4 month-old mdx:S3E mice are protected from arrhythmias upon Iso challenge. Unlike mdx and mdx:S3A, mdx:S3E cardiomyocytes displayed strong Cx43 co-localization with N-Cadherin at the IDs, demonstrating improved Cx43 gap junction targeting. Together, these results suggest that the Cx43-serine triplet contributes toward Cx43 localization and cardiac dysfunction in mdx mice. This project will help identify possible molecular targets for pharmaceutical treatments to protect against cardiac failure and extend the lives of DMD patients.