tbuckley/cabot-search huggingface dataset:
Abstract 14520: Differences in Left Atrial Size and Function and Supraventricular Arrhythmias Between Blacks and Whites in the Atherosclerosis Risk in Communities (ARIC) Study: Implications for AF Pathogenesis
Authors: Wendy Wang, Riccardo M Inciardi, Faye L Norby, Michael J Zhang, Jorge L Reyes, Amil M Shah, Elsayed Z Soliman, Pamela L Lutsey, Alvaro Alonso, Scott Solomon, Lin Y Chen
Journal: Circulation (2020)

Introduction: Black Americans have more atrial fibrillation (AF) risk factors but lower AF risk than whites. Left atrial (LA) enlargement, impaired LA function, frequent premature atrial contractions (PAC), and atrial tachycardia (AT) are risk factors for AF. Racial differences in LA size and function, PAC, or AT may exist that could explain the difference in AF risk. Hypothesis: Whites have higher PAC and AT frequency than blacks. Additionally, whites have larger LA size and lower LA function than blacks, which may contribute to the racial difference in AF. Methods: We included 1,623 ARIC participants free of AF who had 2D-echocardiograms at visit 5 (2011-2013) and wore a 2-week continuous heart monitor, the Zio ® XT Patch, at visit 6 (2016-2017). Weighted linear regression was used to analyze the association of race with LA size and function, as well as runs of AT per day and PAC per hour. Results: At visit 5, participants were 74 (4) years old, 58% were female, and 26% were black. AT runs were detected in 87% of blacks and 92% of whites, respectively (p=0.002). Among participants with &gt;0 runs of AT per day (n=1480), blacks had 48% (95% CI: 21%-66%) fewer runs of AT per day than whites after adjustment for cardiovascular (CV) risk factors † . There was no significant difference in PAC frequency between blacks and whites. After adjusting for age and sex, blacks had greater LA size and lower LA function than whites; these differences attenuated after adjusting for CV risk factors (Table). Conclusion: Blacks have greater age and sex-adjusted abnormality in LA size and function than whites, likely due to higher prevalence of CV risk factors. Yet, blacks have lower propensity for AT. More research is needed to elucidate the mechanisms underlying the resistance to atrial arrhythmogenesis in blacks despite greater adverse LA remodeling.
Abstract 246: Therapeutic Hypothermia Mimicking Peptide Administration During Cardiopulmonary Resuscitation Improved Cardiac Arrest Survival in Swine
Authors: Matt Oberdier, Jing Li, Dan Ambinder, Xiangdong Zhu, Sarah Fink, Henry R Halperin, Terry VandenHoek
Journal: Circulation (2020)

Background: Out-of-hospital sudden cardiac arrest is a leading cause of death in the United States, affecting over 350,000 people per year with an overall survival rate around 10%. CPR, defibrillation, and therapeutic hypothermia are common resuscitation strategies, but hypothermia is difficult to implement timely to achieve survival benefit. A cell-permeable peptide TAT-PHLPP9c has been shown to alter metabolic pathways similar to hypothermia, and decreases the release of two biomarkers, taurine and glutamate, during the high osmotic stress of heart stunning and brain injury in a mouse arrest model. Hypothesis: TAT-PHLPP9c, given during CPR, enhances 24-hour survival in a swine ventricular fibrillation (VF) model. Methods: In 14 (8 controls and 6 treated) sedated, intubated, and mechanically ventilated swine, after 5 min of VF, ACLS with vest CPR and periodic defibrillations was performed. Venous blood samples were collected at baseline, after 2 min of CPR, and at 2 and 30 min after return of spontaneous circulation (ROSC). The animals were survived up to 24 hrs and plasma samples were analyzed for glutamate and taurine in 2 controls and 1 animal given peptide. Results: Three of the control animals had ROSC, but none survived for 24 hrs, while 4 of 6 treated animals achieved neurologically intact survival at 24 hrs (p &lt; 0.02). Compared to baseline, both taurine and glutamate plasma concentrations increased in the control group, but the increase was reduced substantially by the peptide treatment at 30 min after ROSC (Figure). Conclusion: The use of the cooling mimicking peptide TAT-PHLPP9c administered during CPR significantly improved 24-hour survival in this swine model of cardiac arrest. It reduced the increase of cerebral and myocardial metabolic biomarkers, which encourages utilizing a strategy of cell-permeable peptides for intravenous administration for more rapid onset of hypothermia-like salutary effects than are possible with current CPR cooling devices.
Abstract 13610: Endothelial Cu Transporter Atp7a Promotes Vegfr2 Signaling and Post-ischemic Neovascularization via Regulating Autophagy
Authors: Dipankar Ash, Sudhahar Varadarajan, Seock-Won Youn, Mustafa N Okur, John P O'Brien, Malgorzata McMenamin, Xuexiu Fang, Yali Hou, Jack Kaplan, Tohru Fukai, Masuko Ushio-fukai
Journal: Circulation (2020)

Background: VEGFR2 (KDR/Flk1) signaling in endothelial cells (ECs) plays a central role in angiogenesis. Copper (Cu) is essential micronutrient and has been implicated in angiogenesis. The P-type ATPase transporter ATP7A is key regulator of Cu homeostasis but its role in VEGFR2 signaling in ECs and post-ischemic neovascularization is entirely unknown. Results: Here we show that ATP7A expression was dramatically increased in the angiogenic ECs in mice hindlimb ischemia model. EC-specific ATP7A deficient mice or Cu transporter-dysfunctional ATP7A mut mice showed significant decrease in blood flow recovery and CD31+ capillary density (angiogenesis) in ischemic tissues compared to their control mice. In cultured human ECs, ATP7A knockdown with siRNA significantly inhibited VEGF-induced migration (67%), capillary network formation on Matrigel (46%). Immunofluorescence, co-immunoprecipitation, and proximity ligation assays showed that VEGF stimulated ATP7A translocation from the trans-Golgi network to the plasma membrane where it bound to VEGFR2. Surprisingly, loss of ATP7A promoted VEGF-induced VEGFR2 protein degradation (56%) and inhibited VEGFR2 signaling via enhancing VEGFR2 ubiquitination (2.0-fold) in a Cu-independent manner. This was associated with reduced cell surface VEGFR2 expression, increased VEGFR2 binding to selective autophagic cargo/adaptor p62/SQSTM1 (60%) and LC3-GFP+autophagic puncta (34%) and autolysosome formation (transmission electron microscopy). Inhibition of autophagy by bafilomycin A1 or chloroquine prevented enhanced VEGFR2 degradation in ATP7A-depleted ECs. Furthermore, overexpression of p62, but not p62 lacking ubiquitin binding domain, or autophagy inducer rapamycin treatment increased VEGFR2 degradation (26% and 87%, respectively) and p62 overexpression inhibited ECs migration (29%). Enhanced autophagy flux due to ATP7A dysfunction in vivo was confirmed by employing autophagy reporter CAG-ATP7A mut -RFP-EGFP-LC3 transgenic mice. Conclusion: Our study uncovers the unexpected and novel function of ATP7A to limit autophagic degradation of VEGFR2, thereby promoting VEGFR2 signaling and angiogenesis, which restores neovascularization in ischemic disease.
Transcriptional profiles of adjuvanted hepatitis B vaccines display variable interindividual homogeneity but a shared core signature
Authors: Laurane De Mot, Viviane Bechtold, Vanesa Bol, Andrea Callegaro, Margherita Coccia, Ahmed Essaghir, Dicle Hasdemir, Fernando Ulloa-Montoya, Emilio Siena, Age Smilde, Robert A. van den Berg, Arnaud M. Didierlaurent, Wivine Burny, Robbert G. van der Most
Journal: Science Translational Medicine (2020)

Hepatitis B vaccines formulated with different adjuvants induce a consistent core inflammatory signature linked to vaccine immunogenicity.
Use of Topical Sirolimus (Rapamycin) for Treating Confluent and Reticulated Papillomatosis
Authors: David J. Kurtyka, Katherine T. Burke, Cynthia Marie Carver DeKlotz
Journal: JAMA Dermatology (2020)

This case report describes an adolescent male with a history of prediabetes and obesity who presented with a diagnosis of confluent and reticulated papillomatosis with features of acanthosis nigricans.
Venous Thromboembolism Risk With JAK Inhibitors: A Meta‐Analysis
Authors: Mark Yates, Amanda Mootoo, Maryam Adas, Katie Bechman, Sanketh Rampes, Vishit Patel, Sumera Qureshi, Andrew P. Cope, Sam Norton, James B. Galloway
Journal: Arthritis & Rheumatology (2020)

JAK inhibitor therapies are effective treatment options for immune-mediated inflammatory diseases (IMIDs), but their use has been limited by venous thromboembolism (VTE) risk warnings from licensing authorities. We undertook this study to evaluate the VTE risk of JAK inhibitors in patients with IMIDs.Systematic searches of Medline and Embase databases from inception to September 30, 2020 were conducted. Phase II and phase III double-blind, randomized controlled trials (RCTs) of JAK inhibitors at licensed doses were included in our analyses. RCTs with no placebo arm, long-term extension studies, post hoc analyses, and pooled analyses were excluded. Three researchers independently extracted data on exposure to JAK inhibitors or placebo and VTE events (e.g., pulmonary embolism [PE] and deep vein thrombosis [DVT]) and assessed study quality.A total of 42 studies were included, from an initial search that yielded 619. There were 6,542 JAK inhibitor patient exposure years (PEYs) compared to 1,578 placebo PEYs. There were 15 VTE events in the JAK inhibitor group and 4 in the placebo group. The pooled incidence rate ratios (IRRs) of VTE, PE, and DVT in patients receiving JAK inhibitors were 0.68 (95% confidence interval [95% CI] 0.36-1.29), 0.44 (95% CI 0.28-0.70), and 0.59 (95% CI 0.31-1.15), respectively.This meta-analysis of RCT data defines the VTE risk with JAK inhibitors as a class in IMID patients. The pooled IRRs do not provide evidence that support the current warnings of VTE risk for JAK inhibitors. These findings will aid continued development of clinical guidelines for the use of JAK inhibitors in IMIDs.
Abstract 17124: Severe Bradycardia in Critically Ill Patients With COVID-19
Authors: Julie Larue, Patrick De Jode, Jean-François Timsit, Guillaume Franchineau, Fabrice Extramiana, Vincent Algalarrondo
Journal: Circulation (2020)

Cardiac manifestations of severe Covid19 infection are still poorly understood. From January to May 2020, 113 consecutive patients were admitted in intensive care units for severe Covid19 and 10 out of them presented an episode of bradycardia. Patients had a median age of 63 years, 6/10 were men, 7/10 were under mechanical ventilation for severe acute respiratory distress syndrome and 4/10 received a veno-venous extracorporeal membrane oxygenation. All bradycardias were due to sinus node bradycardia with a median heart rate of 36 bpm (range 10 - 45 bpm). For 6 patients, bradycardia was persistent and 3 required continuous isoprenaline infusion (Figure, patient A). Bradycardia was sudden for 4 patients and required brief resuscitation maneuvers for one (Figure, patient B) . Patients had normal baseline ECG and echocardiography, except for two patients who were under beta-blockers. For those two patients beta blockers were interrupted several days before bradycardia. A comprehensive review of patient’s files ruled out bradycardia due to drug-drug interactions, myocarditis, hyperkalemia, hypoxia or vagal physical stimulation. Holter ECG was performed for 7 patients: 3 recordings evoked vagal hyperactivity (low mean heart rate and elevated pNN50 / RMSSD, Figure Patient A), 3 others cardiac dysautonomia (SDNN&lt;100ms, Figure Patient B). Amongst these 10 patients, 5 were discharged from ICU among which 2 returned home and five died from covid-19 associated multiple-organ failure. None of them required temporary or permanent cardiac pacing. To conclude, sinus bradycardia occurred commonly in severe Covid19 infection. This highlights the need to monitor cardiac rhythm. Even if the pathophysiology remains unclear, cardiac dysautonomia and vagal hyperactivity could be hypothesized rather than an intrinsic sinus node disease.
A fixed-duration, measurable residual disease–guided approach in CLL: follow-up data from the phase 2 ICLL-07 FILO trial
Authors: Anne-Sophie Michallet, Rémi Letestu, Magali Le Garff-Tavernier, Carmen Aanei, Michel Ticchioni, Marie-Sarah Dilhuydy, Fabien Subtil, Valerie Rouille, Beatrice Mahe, Kamel Laribi, Bruno Villemagne, Gilles Salles, Olivier Tournilhac, Alain Delmer, Christelle Portois, Brigitte Pegourie, Veronique Leblond, Cecile Tomowiak, Sophie De Guibert, Frederique Orsini Piocelle, Anne Banos, Philippe Carassou, Guillaume Cartron, Luc-Matthieu Fornecker, Loic Ysebaert, Caroline Dartigeas, Malgorzata Truchan-Graczyk, Jean-Pierre Vilque, Thérèse Aurran, Florence Cymbalista, Stéphane Lepretre, Vincent Levy, Florence Nguyen-Khac, Pierre Feugier
Journal: Blood (2020)
Fetal Hemoglobin (HbF) Silencer BCL11A Acts through a Novel DNA-Motif in the Gamma-Globin Promoters, Simplifying the Model for Hemoglobin Switching
Authors: Nan Liu, Victoria V Hargreaves, Jiyoung Hong, Woojin Kim, Jesse Kurland, Qian Zhu, Falak Sher, Claudio Macias-Trevino, Jill Rogers, Guo-Cheng Yuan, Daniel E. Bauer, Jian Xu, Martha L Bulyk, Stuart Orkin
Journal: Blood (2017)
Nitrogen dioxide increases the risk of mortality in idiopathic pulmonary fibrosis
Authors: Hee-Young Yoon, Sun-Young Kim, Ok-Jin Kim, Jin Woo Song
Journal: European Respiratory Journal (2020)

Ambient air pollution is associated with the prognosis of idiopathic pulmonary fibrosis (IPF) patients. We aimed to identify the impacts of individual exposure to particulate matter with a 50% cut-off aerodynamic diameter of 10 μm (PM10) and nitrogen dioxide (NO2) on IPF patients' mortality.1114 patients (mean age 65.7 years; male 80.5%) diagnosed with IPF between 1995 and 2016 were included in this study. Individual-level long-term concentrations of PM10 and NO2 at residential addresses of patients were estimated using a national-scale exposure prediction model. The effect of PM10 and NO2 on mortality was estimated using a Cox proportional hazards model adjusted for individual- and area-level covariates.The median follow-up period was 3.8 years and 69.5% of the patients died or underwent lung transplantation. When adjusted for individual- and area-level covariates, a 10 ppb increase in NO2 concentration was associated with a 17% increase in mortality (hazard ratio (HR) 1.172, 95% CI 1.030-1.344; p=0.016). When IPF patients were stratified by age (≥65 versus <65 years) or by sex, NO2 was a significant prognostic factor for mortality in the elderly (HR 1.331, 95% CI 1.010-1.598; p=0.010). When stratified by age and sex jointly, NO2 showed the stronger association with mortality in elderly males (HR 1.305, 95% CI 1.072-1.598; p=0.008) than in other groups. PM10 was not associated with IPF mortality in all patients and in subgroups stratified by age or sex.Our findings suggest that increased exposure to NO2 can increase the risk of mortality in patients with IPF, specifically in elderly males.
16774 Gold photothermal therapy on acne of Asians: Preliminary study
Authors: Dong-Hye Suh, Tae Jun Park, Jae Yeong Jeong, Ko Eun Kim, Sang Jun Lee, Hyun Joo Kim, Ka Yeun Chang, Hyung Sub Kim, Hwa Jung Ryu
Journal: Journal of the American Academy of Dermatology (2020)
Ten reasons for focusing on the care we provide for family members of critically ill patients with COVID-19
Authors: Élie Azoulay, J. Randall Curtis, Nancy Kentish-Barnes
Journal: Intensive Care Medicine (2020)

The novel coronavirus has become a worldwide threat and healthcare crisis.Since its outbreak in China at the end of 2019, the pandemic has affected millions of people and caused several hundred thousand deaths globally [1].Approximately 20% of hospitalized patients with coronavirus disease 2019 (COVID-19) are admitted to the intensive care unit (ICU) for hypoxemic respiratory failure, and 60 to 90% receive mechanical ventilation [2].Human to human transmission of SARS-CoV-2 occurs mostly through respiratory droplets and through direct contact with an infected patient [3], highlighting the importance of stay-at-home orders [4].Stay-at-home orders, in addition to social distancing guidelines, general pandemic awareness, and restriction of hospital visits, has demonstrated effectiveness not only to reduce the number of people infected by each infected person, but also cumulative hospitalizations [4].This short article discusses the multiple elements that contribute to the difficulty of caring for family members of critically ill patients with COVID-19 in this context, drawing on evidence before and during the COVID-19 pandemic [5][6][7][8].
17011 Azithromycin and rosacea: Case report in a dermatologic medical center in Bogota, Colombia
Authors: David Alfredo Castillo Molina, Jesus Eduardo Jaimes Silva, Gabriela Bula, J. Maria Sanchez, Yensi Lorena Romero Díaz, Diego M. Martinez Zuñiga, Leidy Daniela Zarta Cortés, David E. Castillo
Journal: Journal of the American Academy of Dermatology (2020)
Prevalence of SARS-CoV-2 IgG antibodies in an area of northeastern Italy with a high incidence of COVID-19 cases: a population-based study
Authors: Paola Stefanelli, Antonino Bella, Giorgio Fedele, Serena Pancheri, Pasqualina Leone, Paola Vacca, Arianna Neri, Anna Carannante, Cecilia Fazio, Eleonora Benedetti, Stefano Fiore, Concetta Fabiani, Maurizio Simmaco, Iolanda Santino, Maria Grazia Zuccali, Giancarlo Bizzarri, Rosa Magnoni, Pier Paolo Benetollo, Stefano Merler, Silvio Brusaferro, Giovanni Rezza, Antonio Ferro
Journal: Clinical Microbiology and Infection (2020)

A seroprevalence study of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was conducted in a high-incidence area located in northeastern Italy.All citizens above 10 years of age resident in five municipalities of the Autonomous Province of Trento, with the highest incidence of coronavirus disease 2019 (COVID-19) cases, were invited to participate in the study. Among 6098 participants, 6075 sera and a standardized questionnaire administered face-to-face were collected between 5 May and 15 May 2020 and examined. Symptomatic individuals and their family contacts were tested by RT-PCR. Anti-SARS-CoV-2 antibodies were detected using an Abbott SARS-CoV-2 IgG assay, which was performed on the Abbott Architect i2000SR automated analyser. Seroprevalence was calculated as the proportion of positive results among the total number tested. A multivariable logistic regression model was performed to assess the relationship between seropositive versus seronegative individuals for a set of explanatory variables.A total of 1402 participants were positive for IgG antibodies against SARS-CoV-2, with a prevalence of 23.1% (1402/6075). The highest prevalence was found in the age class 40-49 years. Overall, 34.4% (2096/6098) of the participants reported at least one symptom. The ratio between reported cases identified by molecular test and those with seropositive results was 1:3, with a maximum ratio of about 1:7 in the age group <20 years and a minimum around 1:1 in those >70 years old. The infection fatality rate was 2.5% (35/1402). Among the symptoms, anosmia and ageusia were strongly associated with seropositivity.The estimated seroprevalence of 23% was three-fold higher than the number of cases reported in the COVID-19 Integrated Surveillance data in the study area. This may be explained in part by a relatively high number of individuals presenting mild or no illness, especially those of younger age, and people who did not seek medical care or testing, but who may contribute to virus transmission in the community.
16933 Association of depressive disorders and dermatologic diseases using PHQ-2 as a screening tool in a dermatologic center in Bogota, Colombia
Authors: David Castillo Molina, Marcela Duran Torres, María José Giraldo Parra, Julian Sucerquia, Yensi Lorena Romero Díaz, Gabriela Bula, Jesus Daniel Fierro Lozada, Yinna Katherine Sanchez Sánchez, Leidy Daniela Zarta Cortés, Leidy Daniela Zarta Córtes, David Ernesto Castillo Saavedra
Journal: Journal of the American Academy of Dermatology (2020)
Omalizumab in children and adolescents with chronic urticaria: A 16‐week real‐world study
Authors: Xiao‐ting Song, Yu‐Di Chen, Miao Yu, Bo Liu, Zuo‐tao Zhao, Marcus Maurer
Journal: Allergy (2020)

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Modeling Endoscopic Improvement after Induction Treatment With Mesalamine in Patients With Mild-to-Moderate Ulcerative Colitis
Authors: Christopher Ma, Jenny Jeyarajah, Leonardo Guizzetti, Claire E. Parker, Siddharth Singh, Parambir S. Dulai, Geert R. D’Haens, William J. Sandborn, Brian G. Feagan, Vipul Jairath
Journal: Clinical Gastroenterology and Hepatology (2020)
269MO Comparison of three induction chemotherapy regimens with gemcitabine plus cisplatin, cisplatin plus fluorouracil, and cisplatin plus capecitabine for locoregionally advanced nasopharyngeal carcinoma: A pooled analysis of two prospective studies
Authors: S.K. Chan, C.W. Choi, S.Y. Chan, C.C. Tong, K.O. Lam, D.L.W. Kwong, T.W. Leung, M.Y. Luk, A.W.M. Lee, V.H.F. Lee
Journal: Annals of Oncology (2020)
Multidisciplinary Community-Based Investigation of a COVID-19 Outbreak Among Marshallese and Hispanic/Latino Communities — Benton and Washington Counties, Arkansas, March–June 2020
Authors: Katherine E. Center, Juliana Da Silva, Angela L. Hernandez, Kristyn Vang, Daniel W. Martin, Jerry Mazurek, Emily A. Lilo, Nichole K. Zimmerman, Elisabeth Krow-Lucal, Ellsworth M. Campbell, Janet V. Cowins, Chastity Walker, Kenneth L. Dominguez, Bill Gallo, Jayleen K.L. Gunn, Donald McCormick, Cassie Cochran, Michelle R. Smith, Jennifer A. Dillaha, Allison E. James
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

Characteristic No. (%), [rate] † Total Marshallese Hispanic/Latino White, non-Hispanic Other, non-Hispanic Population 7,712 § (2) 86,581 (17) 365,839 (72) 49,437 (10) 509,569 Laboratory-confirmed cases 647 (19) [8,390] 1,554 (45) [1,795] 432 (13) [118] 803 (23) [1,620] 3,436 [670] Sex ¶ Female 331 (52) 811 (52) 214 (50) 371 (46) 1,727 (51) Male 310 (48) 738 (48) 217 (50) 427 (54) 1,692 (49) Age group (yrs) <18 165 (26) 275 (18) 34 (8) 174 (22) 648 (19) 18-24 74 (11) 194 (12) 51 (12) 103 (13)
Coronavirus Disease 2019 and Effects of School Closure for Children and Their Families—Reply
Authors: Ezra Golberstein, Hefei Wen, Benjamin F. Miller
Journal: JAMA Pediatrics (2020)

In Reply Coronavirus disease 2019 (COVID-19) continues to highlight the critical importance of addressing mental health in children and adolescents and the foundational role of schools. In our Viewpoint,1 we highlighted 3 policy areas that deserved attention.