tbuckley/cabot-search huggingface dataset:
Abstract 13571: Association Between Pre-kidney Transplantation Medial Arterial Calcification Andpost-transplant Visit-to-visit Blood Pressure Variability: A Propensity Score Matching Analysis
Authors: Ekamol Tantisattamo, Sakditad Saowapa, Natnicha Leelaviwat, Busara Songtanin, Chawit Lopimpisuth, Possawat Vutthikraivit, Natchaya Polpichai
Journal: Circulation (2020)

Introduction: Arterial calcification is associated with vascular stiffness, which manifests with visit-to-visit blood pressure variability (VVBPV). Although media arterial calcification (MAC) is significantly associated with poor cardiovascular outcomes in kidney patients, the association in kidney transplant (KT) patients is unknown. Hypothesis: We hypothesize that MAC is associated with VVBPV in long-tern post-KT. Methods: Since MAC, which is detected from mammogram (MG) and determined by linear calcified breast arteries, is exclusively medial, female KT patients with ≥1 MG during pre-KT period were included in this study. VVBPV was examined by average successive variability (ASV), which is the average absolute difference between successive BP measured at 4, 12, 24, 36, and 48 weeks post-KT. After balancing patients with and without MAC by using propensity score matching based on age, diabetes, and obesity status, the association between MAC and systolic and diastolic VVBPV (VVSBPV and VVDBPV) at 48 weeks post-KT was tested by multiple linear regression (Figure1A&amp;1B). Results: Of 51 patients, mean age±SD is 54±12 years, 21 had diabetes, and 21 were obese. Mean duration of follow-up was 47±9 years. Among 20 patients with MAC, mean VVSBPV was 20±14 mmHg; whereas, VVSBPV in non-MG group was 14±8 mmHg (mean difference -6± 3.0, p 0.06, 95%CI -12.03, 0.15). Mean VVDBPV in MG and non-MG groups were 12±5 and 11±5.6 mmHg, respectively (mean difference -1±1.6, p 0.41, 95%CI -4.44, 1.86). Laboratory-related bone and mineral metabolism were not different between both groups. On average, MG group had 8 mmHg higher VVSBPV compared to non-MG group (Coef. 3.62, p 0.02, 95%CI 1.16, 15.34). The MG group remained having higher VVDBPV but the magnitude of the association decreased and no statistical significance (Coef. 0.58, p 0.83, 95%CI -4.58, 5.73). Conclusions: Similar to non-transplant patients, KT recipients with pre-KT MAC had significant higher VVSBPV at the late post-KT.
Abstract 12935: Predictors of Long-term Success After Catheter Ablation of Premature Ventricular Complexes
Authors: Sung Il Im, Aleksandr Voskoboinik, Adam C Lee, satoshi higuchi, byron lee, Henry H Hsia, Joshua Moss, Vasanth Vedantham, Gregory M Marcus, zian Tseng, Randall J Lee, melvin scheinman, Edward GERSTENFELD
Journal: Circulation (2020)

Introduction: Some patients(pts) have late recurrence after acutely successful radiofrequency catheter ablation(RFCA) of premature ventricular complexes (PVC). Hypothesis: The aim of this study was to evaluate predictors of long term success following acutely successful PVC ablation. Methods: From 2016-19, we identified consecutive pts at our institution with frequent PVCs undergoing RFCA and reviewed procedural data and medical records. Earliest local activation on the intracardiac bipolar and unipolar electrogram was measured using digital calipers. Acute success was defined as elimination of targeted PVC for at least 30 mins after RFCA. Long term success was defined as absence of PVC on 12 lead ECG during all follow up (f/u) visits and PVC burden reduction &gt;80% or PVC burden &lt;5% on f/u monitoring at 1 year. Results: Among 241 pts, 161 (66.8%) pts had long term success with mean f/u of 17.6±5.8 months.In univariate analysis, diabetes mellitus and alcohol use were associated with PVC recurrence while age, female sex, acute success, ablation time, right ventricular PVC origin, single PVC morphology (sPVC), and earliest bipolar activation&gt;24msec pre-QRS were associated with long-term success. In multivariate analysis, female sex, sPVC and earliest activation &gt;24 msec preQRS were independent predictors of long term success at 1 year. The positive predictive value of earliest bipolar onset preQRS of PVC&gt;24msec for long term success was 0.77(P&lt;0.001). Negative predictive value of earliest onset preQRS &lt;15msec for long term success was 0.86(P=0.003), suggesting that ablation when the local bipolar electrogram preceded the QRS by &lt;15ms was unlikely to result in long term success. Conclusions: Female gender, sPVC, and earliest onset of bipolar electrogram preQRS&gt;24msec were predictors of long term success in patients with PVC undergoing RFCA. If local onset is &lt;15ms, RF ablation is not worthwhile. The reason for improved outcome in females requires further study.
Frailty Assessment and Shared Decision-making
Authors: Larry W. Kraiss, Benjamin S. Brooke
Journal: JAMA Surgery (2021)

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RNA helicase DDX5 enables STAT1 mRNA translation and interferon signalling in hepatitis B virus replicating hepatocytes
Authors: Jiazeng Sun, Guanhui Wu, Florentin Pastor, Naimur Rahman, Wen-Hung Wang, Zhengtao Zhang, Philippe MERLE, Lijian Hui, Anna Salvetti, David Durantel, Danzhou Yang, Ourania Andrisani
Journal: Gut (2021)

RNA helicase DDX5 is downregulated during HBV replication and poor prognosis HBV-related hepatocellular carcinoma (HCC). The objective of this study is to investigate the role of DDX5 in interferon (IFN) signalling. We provide evidence of a novel mechanism involving DDX5 that enables translation of transcription factor STAT1 mediating the IFN response.
Abstract 16009: Sex Differences in Patients With Suspected Cardiac Sarcoidosis
Authors: Rajat Kalra, Ko-hsuan Chen, Pratik Velangi, Osama Okasha, Jeremy Markowitz, Prabhjot S Nijjar, Lisa Von Wald, Henri Roukoz, Maneesh Bhargava, David Perlman, Afshin FARZANEH-FAR, Chetan Shenoy
Journal: Circulation (2020)

Introduction: Cardiac sarcoidosis is increasingly recognized as a cause of cardiomyopathy and mortality. However, there are no data on sex differences in patients with suspected cardiac sarcoidosis. Hypothesis: We hypothesized that sex differences exist in the clinical presentation, cardiac involvement, and long-term clinical outcomes of patients with suspected cardiac sarcoidosis. Methods: We performed a retrospective cohort study to examine sex differences in presenting features, CMR findings, and the long-term incidence of adverse clinical outcomes among consecutive patients with histologically proven sarcoidosis and suspected cardiac involvement investigated by cardiovascular magnetic resonance imaging (CMR). The primary composite clinical endpoint was all-cause mortality or significant ventricular arrhythmia. The secondary endpoints were all-cause mortality and significant ventricular arrhythmia. Results: Among 324 patients, 163 (50.3%) were women and 161 (49.7%) were men. Women reported a greater prevalence of chest pain and palpitations than men, but not dyspnea, presyncope, or syncope. Women were less likely to have LGE or meet the criteria for a clinical diagnosis of cardiac sarcoidosis, indicating lesser cardiac involvement. The long-term incidence of the primary composite endpoint (hazard ratio for women 1.36; 95% confidence interval 0.77-2.43; p = 0.29; Figure 1 ) or the cause of death between women and men (p = 0.62). However, women had a significantly lower cumulative incidence of significant ventricular arrhythmia compared with men (4.3% vs. 13.0%; log-rank p = 0.022). Conclusions: There were distinct sex differences in patients with histologically proven sarcoidosis and suspected cardiac involvement. A paradox was noted wherein women had a greater prevalence of chest pain and palpitations than men, but had lesser cardiac involvement, and a similar long-term incidence of all-cause death or significant ventricular arrhythmia.
Abstract 17008: Cardiologist Adherence to Physical Activity Guidelines: Failure to Walk the Walk
Authors: Sarah K Gualano, Paul Theriot, Laxmi S Mehta, Claire S Duvernoy
Journal: Circulation (2020)

Introduction: The 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease recommends adults engage in ≥ 150 minutes of moderate or ≥75 minutes of vigorous intensity aerobic activity per week to reduce cardiovascular risk. Cardiologist adherence to these guidelines is unknown. Methods: Electronic surveys were sent to 437 ACC CardioSurve cardiologists, a representative sample of current ACC members. Demographic data was collected. Respondents were asked to quantify and rate intensity of exercise in an average week. Results: Between February and March 2020, a total of 189 panelists completed the survey for a response rate of 43%, of which 13% were women. There was even representation in number of years in practice: 33% early career, 27% mid-career, and 35% late career. Cardiologists across all career stages were evenly represented; 33% early career, 27% mid-career, and 35% late career. Overall only 56% of cardiologists met exercise guidelines (Figure). Less than half participated in vigorous activity (46%) with higher prevalence among mid versus early career (58% vs 38%, p=0.035). Interventional cardiologists were less likely to meet the standards for exercise intensity compared to general cardiology (44% vs. 59%, p=0.09). Early career respondents were less likely to adhere to activity recommendations (39% vs 59%, p=0.018). Those who reported vigorous activity were more likely to strength train at least twice per week (43% vs. 15%, p &lt; 0.001). Conclusions: Nearly half of cardiologists are not adherent to the ACC recommended guidelines for aerobic activity. The impact on cardiologists’ health was not quantified, but this study suggests there is room for improvement in prevention behaviors. Since physicians are known to serve as role models for their patients, we hypothesize lack of adherence to activity guidelines may also negatively impact our patients.
Abstract 15164: Exploring the Use of a 30-Year Cardiovascular Risk Prediction to Guide Statin Eligibility in Primary Care
Authors: Fernando H Cesena, Antonio G Laurinavicius, Viviane A Valente, Raquel D Conceição, Raul D Santos, Marcio S Bittencourt
Journal: Circulation (2018)

Introduction: Statin eligibility based on long-term risk assessment has been suggested but it is not well known how this approach should be used and its impact in clinical practice. The goals of th...
Abstract 17410: Geographic and Racial/ Ethnic Disparities in Heart Transplant Listing by County and Associated Risk Factors
Authors: Justin T Parizo, Fatima Rodriguez, Alexander T Sandhu, Manisha Desai, Kiran K Khush
Journal: Circulation (2020)

Introduction: It is unknown if there are disparities in the transition from heart failure (HF) to listing for heart transplant (HT), although there are clear disparities in this transition in the transplant of other organs. Methods: We used CDC WONDER data and SRTR transplant data to identify county-level age-adjusted HF mortality and number of candidates listed for HT from 2006 to 2018 among racial/ ethnic subgroups. We determined rates of candidate listing and age-adjusted HF deaths (AAHFD) per 100,000 persons on aggregate and by racial/ ethnic subgroups. County-level demographic, socioeconomic, cardiovascular disease risk, and healthcare factors from public databases were used in multivariate models to determine factor groups explaining variation in candidates listed per AAHFD. Results: The median (IQR) candidates per AAHFD for the aggregated county cohort was 1.3 (0.75-2.0; 2558 counties reported data), the non-Hispanic white (NHW) county cohort was 1.5 (0.88-2.2; 2426 counties), the non-Hispanic black (NHB) county cohort was 1.1 (0.64-1.6; 860 counties), and the Hispanic county cohort was 1.1 (0.67-1.8; 254 counties) (p-value &lt;0.001). The lowest candidates per AAHFD were in the South for NHW (median 1.3) and NHB (0.97), but in the West for Hispanic (0.84). Multivariate models with all county-level variables, explained (R 2 ) 28.7%, 38.7%, and 57.3% of variation in candidates listed per AAHFD for NHW, NHB, and Hispanic cohorts, respectively. Socioeconomic factors (R 2 0.14), healthcare factors (R 2 0.21), and cardiovascular disease risk factors (R 2 0.18), respectively, explained the greatest variation in models using variable subgroups. Conclusions: When age-adjusted rates of HF mortality by race/ ethnicity group is considered, HT candidate listing for NHB and Hispanic candidates is 27% lower than for NHW. County-level factors that explain variation in HT listing vary by racial/ ethnicity group, and explain more variation in NHB and Hispanic cohorts.
Incidence of detecting mutated k-ras DNA in urine, plasma and serum from patients with colorectal carcinoma or adenomatous polyps
Authors: Ying-Hsiu Su, Mengjun Wang, Dean E. Brenner, Daniel Normolle, Sapna Syngal, Robert Bresalier, Timothy M. Block
Journal: Cancer Research (2006)

654  Introduction: Colorectal neoplasia-associated genes have been detected in human blood (serum or plasma). We have previously demonstrated that urine contained tumor tissue derived DNA from the circulation (Su et. al. J Mol Diagnosis 2004). The advantages of non-invasive and the larger volume available for urine collection make it compelling to explore its application in clinical use. In this study, we compared the incidence of detecting mutated k-ras DNA in body fluid (serum, plasma, and urine), and the frequency of mutated k-ras DNA detected in individuals in different colorectal diseases in a blinded study. Methods: Mutated K-ras DNA was assayed by two methods, restriction endounuclease enriched PCR assay (> 2 copies per assay) and Peptide nucleic acid clamping real time PCR (>15 copies per assay). Human subjects: Training set_20 patients with known k-ras mutations in colorectal cancer tissue. Test set_blinded urine samples from colorectal adenocarcinoma (N=48), adenoma (N=31), hyperplastic polyp (N=12) and endoscopically normal colon and rectum (N=60). Results: 1. Open label (training set) K-ras detection (tissue confirmed k-ras mutations): The incidence of detecting mutated K-ras DNA: Serum 6/20 (30%), Plasma (11/20 (55%), Urine: 18/20 (90%), (p 2 copies of mutated K-ras genes were detected in: 16/48 (33%) adenocarcinomas; 23/31 (74%) adenomas; 5/12 (42%) hyperplastic polyps, and 19/60 (31%) non-neoplasia controls. b. >15 copies of mutated K-ras genes were detected in: 12/48 (25%) adenocarinomas; 15/31 (48%) adenomas; 3/12 (25%) hyperplastic polyps, and 11/60 (18%) non-neoplasia controls. The concurrence of k-ras mutation in disease tissue and its corresponding total urine DNA or low MW urine DNA was determined. Strikingly, the concurrence and sensitivity of detecting mutated K-ras DNA using low MW urine DNA was 84% and 90%, respectively, as compared to only 45% and 50% if total urine DNA was used in the assay for K-ras mutation. Conclusions: The sensitivity for the detection of K-ras mutations in urine appears at least equivalent if not superior to K-ras mutation detection from human blood. These results suggest that to enhance the sensitivity of detecting circulating tumor related DNA in urine, low MW urine DNA should be used. The detection of the K-ras mutation alone is insufficient as a diagnostic biomarker for colorectal neoplasia, but it may be useful in a panel of DNA mutational biomarkers.
The role of the HIF‐1α/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer
Authors: Jing‐Zi Wang, Wei Zhu, Jie Han, Xiao Yang, Rui Zhou, Hong‐Cheng Lu, Hao Yu, Wen‐Bo Yuan, Peng‐Chao Li, Jun Tao, Qiang Lu, Ji‐Fu Wei, Haiwei Yang
Journal: Cancer Communications (2021)

As a rate-limiting enzyme of glycolysis, pyruvate kinase muscle isozyme M2 (PKM2) participates in tumor metabolism and growth. The regulatory network of PKM2 in cancer is complex and has not been fully studied in bladder cancer. The 5-methylcytidine (m5C) modification in PKM2 mRNA might participate in the pathogenesis of bladder cancer and need to be further clarified. This study aimed to investigate the biological function and regulatory mechanism of PKM2 in bladder cancer.The expression of PKM2 and Aly/REF export factor (ALYREF) was measured by Western blotting, qRT-PCR, and immunohistochemistry. The bioprocesses of bladder cancer cells were demonstrated by a series of experiments in vitro and in vivo. RNA immunoprecipitation, RNA-sequencing, and dual-luciferase reporter assays were conducted to explore the potential regulatory mechanisms of PKM2 in bladder cancer.In bladder cancer, we first demonstrated that ALYREF stabilized PKM2 mRNA and bound to its m5C sites in 3'-untranslated regions. Overexpression of ALYREF promoted bladder cancer cell proliferation by PKM2-mediated glycolysis. Furthermore, high expression of PKM2 and ALYREF predicted poor survival in bladder cancer patients. Finally, we found that hypoxia-inducible factor-1alpha (HIF-1α) indirectly up-regulated the expression of PKM2 by activating ALYREF in addition to activating its transcription directly.The m5C modification in PKM2 mRNA in the HIF-1α/ALYREF/PKM2 axis may promote the glucose metabolism of bladder cancer, providing a new promising therapeutic target for bladder cancer.
Abstract 16174: Age, Race, and Gender Related Cardiovascular Morbidity of Patients Hospitalized With Periodontal Disease
Authors: Omar Chehab, Maria Doughan, Rami Z. Morsi, Amjad Kanj, Ali Abdallah, Mohit Pahuja, Bassel Doughan, Aiden A Abidov
Journal: Circulation (2020)

Introduction: Periodontal disease (PD) is an acquired disorder characterized by inflammation of the gums, resulting eventually in loss of teeth. Epidemiological studies have shown a link between PD and cardiovascular diseases (CVDs). The aim of this study is to evaluate differences in the prevalence of CVD amongst US patients with PD of different age, race and sex. Method: Using the US national in-patient sample database (NIS) from 2005-2014, patients with PD and CVD were identified. Results: 155,732 hospitalizations with PD were included in the study, of which 36.5% had at least one CVD. Ischemic heart disease was the most prevalent CVD (17.6%), followed by heart failure (10.9%), atrial fibrillation/flutter (10.1%) and cerebrovascular disease (CRVD) (9.7%). The overall in-hospital mortality was higher in PD patients with CVD (2.6% vs 1.2%, p&lt;0.0001). Figure 1C highlights the prevalence of various subtypes of CVD among different gender. When stratifying hospitalized patients with PD and CVD based on race and age, there was higher prevalence of CVD among Asians and Pacific Islanders (42.4%) (Figure 1A-B) and with increasing age (≥70, 56-69, and 18-55; 67.4% vs 50.1% vs 20.3%, p&lt;0.001, respectively). Significant increase trends in the prevalence of AF, HF, and CRVD in the young, middle, and older age group was noted (P-trend&lt;0.001) (Figure1A). Conclusion: CVD is prevalent in patients with PD and is more common in males and among Asians and Pacific Islanders. Higher mortality was reported among hospitalized PD patients with CVD. An increase in trend in the prevalence of AF, HF, and CRVD was noted across all age groups. This may require age, race, and gender specific strategies in PD patients for primary prevention of different CVD.
Abstract 16639: A Novel Approach to Model Heart Failure With Preserved Ejection Fraction in Rats
Authors: Kenichi Katsurada, Shyam S Nandi, Neeru M Sharma, Kaushik P Patel
Journal: Circulation (2020)

Introduction: Diastolic dysfunction and cardiac hypertrophic remodeling are hallmark features of heart failure with preserved ejection fraction (HFpEF) in humans. However, an ideal animal model that mimics all these basic clinical features of HFpEF remains to be developed. Methods: Male Sprague-Dawley rats (250-300 g) were subjected to central infusion of either Angiotensin II (Ang II at 20 ng/min, 0.5 μl/h, i.c.v) or isotonic saline (0.5 μl/h, i.c.v) through osmotic mini-pumps for 14 days. Echocardiography was used to measure systolic (ejection fraction) and diastolic functions (E/A and E/E’ ratio) at day 14. Mean arterial pressure (MAP), heart rate (HR), left ventricular pressure (LVP), changes in ±dP/dt, and cardiac responses to isoproterenol (ISO) were also measured in anesthetized rats. Results: Central infusion of Ang II in rats resulted in increased sympathoexcitation and mean arterial pressure. Concomitantly, there was decreased E/A ratio (AngII: 1.2 ± 0.1 vs. Cont: 1.5 ± 0.1) and increased E/E’ ratio (AngII: 14.3 ± 0.8 vs. Cont: 12.9 ± 0.6), indicating diastolic dysfunction. Ejection fractions were comparable between the groups (AngII: 67 ± 2% vs. Cont: 69 ± 5%). Ang II infused rats demonstrated increased heart to body weight ratio (AngII: 4.5 ± 0.5 vs. Cont: 2.9 ± 0.1), cachexia (AngII: 235 ± 18 g vs. Cont: 331 ± 11 g), hypertrophy (AngII: 46 ± 5 μm/unit area vs. Cont: 36 ± 7 μm/unit area), and fibrosis (AngII: 5.2 ± 0.5 intensity/unit area vs. Cont: 2.6 ± 0.4 intensity/unit area). At the same time cardiac contractile responsiveness to ISO (0.5 μg/kg) was significantly lower for negative dP/dt in Ang II rats (AngII: -6998 mmHg/s vs. Cont: -11675 mmHg/s), which is indicative of abnormal diastole or relaxation. However, positive dP/dt response to ISO was similar in the two groups, indicating preserved systolic function in the Ang II group. Conclusions: Central Ang II infusion in rats shows sympathoexcitation, diastolic dysfunction, and pathological cardiac hypertrophy and fibrosis mimicking abnormalities seen in patients with HFpEF. This model of cardiac dysfunction in rats may represent a suitable platform to investigate the underlying mechanisms of HFpEF.
腎不全を有する/有しない慢性心不全における心臓死の予測に対する心I-123メタヨードベンジルグアニジンイメージングの有用性:前向き調査
Authors: Iwasaki Yusuke, Yamada Takahisa, Okuyama Yuji, Morita Takashi, Sanada Shoji, Furukawa Yoshio, Tsukamoto Yasumasa, Masuda Masaharu, Okuda Keiji, Yasui Taku, Fukunami Masatake
Journal: Circulation (2008)
종설 : 간세포암종에서 방사선 치료의 최신 지견
Authors: 성진실 ( Jin Sil Seong )
Journal: Clinical and Molecular Hepatology (2004)

With the accumulation of clinical experiences, the efficacy of radiotherapy has been recognized in management scheme for HCC. While hepatologists are beginning to show less reluctance for applying radiotherapy to the treatment of HCC, it is necessary that