tbuckley/cabot-search huggingface dataset:
Non-invasive photobiomodulation treatment in an Alzheimer Disease-like transgenic rat model
Authors: Luodan Yang, Chongyun Wu, Emily Parker, Yong Li, Yan Dong, Lorelei Tucker, Darrell W. Brann, Hung Wen Lin, Quanguang Zhang
Journal: Theranostics (2022)

Alzheimer's disease (AD) is the most common form of dementia in the elderly, causing neuronal degeneration and cognitive deficits that significantly impair independence and quality of life for those affected and their families.Though AD is a major neurodegenerative disease with vast avenues of investigation, there is no effective treatment to cure AD or slow disease progression.The present work evaluated the therapeutic effect of long-term photobiomodulation (PBM) treatment with continuous-wave low-level laser on AD and its underlying mechanism.Methods: PBM was implemented for 2 min, 3 times per week for 16 months in 2-month-old transgenic AD rats.A battery of behavioral tests was performed to measure the effect of PBM treatment on cognitive dysfunction in AD rats.The effects of PBM therapy on typical AD pathologies, including amyloid plaques, intracellular neurofibrillary tangles, neuronal loss, neuronal injury, neuronal apoptosis, and neurodegeneration, were then assessed.The underlying mechanisms were measured using immunofluorescence staining, western blotting analysis, mass spectrometry, primary cortical and hippocampal cell cultures, and related assay kits.Results: PBM treatment significantly improved the typical AD pathologies of memory loss, amyloid plaques, tau hyperphosphorylation, neuronal degeneration, spine damage, and synaptic loss.PBM treatment had several mechanistic effects which may explain these beneficial effects, including 1) regulation of glial cell polarization and inhibition of neuroinflammation, 2) preservation of mitochondrial dynamics by regulating fission and fusion proteins, and 3) suppression of oxidative damage to DNA, proteins, and lipids.Furthermore, PBM enhanced recruitment of microglia surrounding amyloid plaques by improving the expression of microglial IL-3Rα and astrocytic IL-3, which implies a potential role of PBM in improving Aβ clearance.Finally, our results implicate neuronal hemoglobin in mediating the neuroprotective effect of PBM, as Hbα knockdown abolished the neuroprotective effect of PBM treatment.Conclusion: Collectively, our data supports the potential use of PBM treatment to prevent or slow the progression of AD and provides new insights into the molecular mechanisms of PBM therapy.
Spontaneous Haemopneumothorax
Authors: J. Maxwell
Journal: BMJ (1938)

MtED!ICAL JOURNAL from the clinical standpoint, but the radiological appear- ances were not diagnostic.2. The tumour infiltrated the heart muscle and the left lung and pleura, but the pericardium was free from in- volvement.The arch of the aorta and great vessels were surrounded by the tumour, but not infiltrated.3. The origin of the tumour cannot be stated with any degree of certainty, but it appears to be a primary growth in the thymus gland itself.4. The microscopical findings show the tumour to be cornposed of a diffuse undifferentiated mass of cells resembling small lymphocytes.It is not a true " thymoma" in the strictest pathological sense, but more correctly a malignant lymphoma.5. Post-mortem findings indicate that death was due to asphyxia and venous obstruction.
Drinking behaviour.
Authors: H G Kinnell
Journal: BMJ (1977)

nioxythiolin-free control.A 10-[u sample from each tube was plated on blood agar at 0, 1, 1, 2, 4, and 24 h.The results for one of the organisms tested with 10" bacteria added to 1 ml of solution are shown in the table.It can be seen that 2 h exposure -was required for killing by a 10 g 1 solutioni of noxythiolin, although the N\BC as prexviously determined was 2 g 1.Two other organisms (MBC 1 g 1) when tested with 10' organisms ml showed complete killing by 20 g 1 in 1 h, by 10 g 1 in 2 h and by both 5 g 1 and 2 5 gl1 in 4 h.
Abstract 17300: Development and Ex Vivo Validation of Novel Force-Sensing Neo-Tendons for Measuring Chordae Tendineae Tension in the Mitral Valve Apparatus Using Optical Fibers With Embedded Bragg Gratings
Authors: Michael J Paulsen, Jung Hwa Bae, Annabel M Imbrie-Moore, Hanjay Wang, Camille E Hironaka, Haley J Lucian, Bryan B Edwards, Justin M Farry, Daniela Deschamps, Rohun Kulkarni, Akshara D Thakore, Kiah M Williams, Mark R Cutkosky, Y. Joseph Woo
Journal: Circulation (2018)

Introduction: Very few technologies exist that can provide quantitative data on forces within the mitral valve apparatus. Marker based strain measurements can be performed, but chordae heterogeneity limits utility. Foil-based strain sensors have also been described, but tend to be bulky, limiting the number of chordae that can be measured. Hypothesis: We hypothesize that the use of Fiber Bragg Grating (FBG) sensors—optical strain gauges made of 125 μ m diameter silica fibers— can overcome the critical limitations of previous methods of measuring chordae tendineae forces. Methods: Using FBG sensors, we created a force-sensing neochord that would mimic the natural shape and movement of native chordae tendineae. FBG sensors reflect a specific wavelength of light depending on the spatial period of gratings - when a force is applied, the gratings move relative to one another, changing the reflected light (Fig 1A). This wavelength shift is directly proportional to the force applied. The FBG sensors were housed in a protective sheath fashioned from the outer coil of a 0.025" Amplatz Extra-Stiff guidewire, and attached to the chordae using GoreTex suture (Fig 1B). The function of the force-sensing neochordae were validated in a 3D printed left heart simulator. Results: FBG sensors provided high-fidelity force measurements of mitral valve chordae tendineae at a temporal resolution of 1000 Hz. As ventricular pressures increased, such as in the hypertensive condition, forces on the chordae also increased (Fig 1C). The resolution of FBG sensors allow for increased accuracy of not only chordae tension, but also the rate of change of force (dF/dt) - a parameter critical to determining likelihood of leaflet rupture. Conclusions: FBG sensors are a viable, durable, and high-fidelity technology that can be effectively used to measure mitral valve chordae forces and overcome limitations of other such technologies.
Myocardial infarction
Authors: M. F Ryan
Journal: BMJ (1988)

encountered similar cases to those described by Dr D Thompson and others (7 May, p 1309) in which initial radiographs showed only degenerative changes, and only incessant pain and a raised erythrocyte sedimentation rate gave the clue that this was more serious than osteoarthritis.Two patients who were subsequently found to have staphylococcal septicaemia and vertebral osteomyelitis gave a clear history of recent trauma -in one a fall down stairs and in the other a fall in her garden.Similar pitfalls exist when elderly patients presenting with back pain are found later to have spinal metastases or myeloma (this is more common than vertebral osteomyelitis).The authors do not.mention isotope bone scanning.This can often determine the site of the lesion when radiographs are not helpful and may show involvement of other parts of the skeleton that is not obvious clinically.
Prescription charges.
Authors: G. Stein
Journal: BMJ (1968)

the investigation of suspected myclomatosis.His formal intelligence, as assessed by medical testing, was diminished.He failed the Babcock sentence seven times and could only repeat five numbers forwards and four backwards after several attempts.On the other hand, he had a ready wit and a sharp repartee.His affect was normal.No local abnormalities of the nervous system were detected.There was a vague history of taking quinalbarbitone, amnylobarbitone, or carbromal, and also Serensil (ethchlorvynol).After admission he was given no drugs.Three days later he had his first convulsion without premonition.A tonic phase during which he was cyanosed lasted a few minutes.There was faecal, but not urinary, incontinence.After the fit he was confused and disorientated in time and space, with immediate preictal amnesia.Later the same day he had a second fit and was subsequently given phenobarbitone.Postictal examination of the central nervous system showed hypertonicity and hyperreflexia.The gait was ataxic.No focal abnormalities were found.For four days after the convulsions there was marked mood change and confusion, his affect swinging between ebullience and aggression.He swore at the nurses and tried to strike them and had visual and auditory hallucin- ations.Eleven days after the fits, on discharge, his mood was normal.Tests following the con- vulsions-serology of the blood and C.S.F., esti- mation of the blood bromide, skull' x-rays, E.E.G., echogram, and gamma scan-showed no significant abnormality.
Impaired phosphocreatine metabolism in white adipocytes promotes inflammation
Authors: Salwan Maqdasy, Simon Lecoutre, Gianluca Renzi, Scott Frendo-Cumbo, David Rizo-Roca, Thomas Moritz, Marta Juvany, Ondrej Hodek, Hui Gao, Morgane Couchet, Michael Witting, Alastair Kerr, Martin O. Bergo, Robin P. Choudhury, Myriam Aouadi, Juleen R. Zierath, Anna Krook, Niklas Mejhert, Mikael Rydén
Journal: Nature Metabolism (2022)

Abstract The mechanisms promoting disturbed white adipocyte function in obesity remain largely unclear. Herein, we integrate white adipose tissue (WAT) metabolomic and transcriptomic data from clinical cohorts and find that the WAT phosphocreatine/creatine ratio is increased and creatine kinase-B expression and activity is decreased in the obese state. In human in vitro and murine in vivo models, we demonstrate that decreased phosphocreatine metabolism in white adipocytes alters adenosine monophosphate-activated protein kinase activity via effects on adenosine triphosphate/adenosine diphosphate levels, independently of WAT beigeing. This disturbance promotes a pro-inflammatory profile characterized, in part, by increased chemokine (C-C motif) ligand 2 (CCL2) production. These data suggest that the phosphocreatine/creatine system links cellular energy shuttling with pro-inflammatory responses in human and murine white adipocytes. Our findings provide unexpected perspectives on the mechanisms driving WAT inflammation in obesity and may present avenues to target adipocyte dysfunction.
Intestinal spirochaetosis
Authors: F. D. Lee, A. Kraszewski, J. Gordon, J. G. R. Howie, D. McSeveney, W. A. Harland
Journal: Gut (1971)

An abnormal condition of the large intestine is described in which the surface epithelium is infested by short spirochaetes. Diagnosis can be made by light microscopy. A review of 14 cases diagnosed by rectal biopsy and 62 cases involving the appendix shows no consistent symptom complex. The possible significance is discussed.
Nanoplatform Self‐Assembly from Small Molecules of Porphyrin Derivatives for NIR‐II Fluorescence Imaging Guided Photothermal‐Immunotherapy
Authors: Yanbing Cao, De Wei, Lixia Yang, Zijin Luo, Peiwen Yu, Hao Li, Cao Zhang, Xiaolong Liu, Fengshou Wu, Ming Wu, Yongyi Zeng
Journal: Advanced Healthcare Materials (2022)

Combinatorial photothermal and immunotherapy have demonstrated great potential to remove primary tumors, suppress metastases, and prevent tumor recurrence. However, this strategy still confronts patients with many limitations, such as complex components, sophisticated construction, and inadequate therapeutic efficacy. In this work, small molecules of porphyrin derivatives (PPor) which can self-assemble into monodispersed nanoparticles without supplement of any other ingredients or surfactants are developed. The formed PPor nanoparticles (PPor NPs) exhibit highly photothermal conversion efficiency of 70% and NIR-II luminous abilities originate from the strong intramolecular charge transfer (ICT) effect of D-A structure under 808 nm laser irradiation, thus achieving NIR-II fluorescence imaging guided photothermal therapy (PTT) against primary tumors with a high cure rate. More importantly, tumor-associated antigens (TAAs), together with damage-associated molecular patterns (DAMPs) released from PTT-treated cancer cells, are proved to elicit immune responses to some degree. After combination with programmed cell death-1 (PD-1) antibodies, a robust systematic antitumor immunity is generated to restrain both primary and abscopal tumors growth, prolong survival, and prevent pulmonary metastasis on an aggressive 4T1 murine breast tumor model. Thus, this study provides a promising therapeutic paradigm with porphyrin derivatives nano-assembly as phototheranostic agents for the treatment of aggressive tumors with high efficiency.
Healthy aging and muscle function are positively associated with NAD+ abundance in humans
Authors: Georges E. Janssens, Lotte Grevendonk, Ruben Zapata Perez, Bauke V. Schomakers, Johan de Vogel-van den Bosch, Jan M. W. Geurts, Michel van Weeghel, Patrick Schrauwen, Riekelt H. Houtkooper, Joris Hoeks
Journal: Nature Aging (2022)
Lectures on the Varieties in the Muscles of Man
Authors: G. M. Humphry
Journal: BMJ (1873)

THE rectus abdominis varies a little in the number and site of its in- scriptions and in the range of its attachment to the pubes.The most remarkable varieties, however, associated with it, are the occasional recurrence in the thoracic part of the trunk of two muscles longitudi- nally disposed and situated, the one on the superficial aspect of the pectoral muscles, and the other beneath them, and lying close upon the ribs.They are interesting reminders of the primitive disposition of the sheets of the ventral muscle at this part, and as such deserve a more * Such a connection of the platysma with the costal cartilage is, however, indi- cated as having been seen by Teichmann.-IZdeoz, io8.Ol'se'valions in l1yotooy, p. I32.$yonrnza of Anzatomoy, ii,392; and iv, 3oo.See also Gay's Hosit/al Retorts XiV, 439; and Bochdalek, 'I';-c/zoiz' As U'i, 1867.These are sometimes described as muscles arising from the ribs and joining the scaleni.* ALem;e.dc Z'Acad.Ideji.e St. Petersbourg, 1. iii, I86o.t In two of Turner's cases (7ournal ofAnatomy, i, 247), the outer fibres ended superficially in the upper part of the pectoral aponeurosis.
GYNÆCOLOGY.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstracts
Journal: Annals of the Rheumatic Diseases (1963)

The records of fifty cases of juvenile rheumatoid arthritis treated between 1953 and 1960 at the Royal Alexandra Hospital for Children, Sydney, were reviewed, chiefly from the standpoint of initial symptoms.There were thirty girls, and thirty of the fifty children were under 5 years of age at the onset.The disease tended to be more severe in the younger children.Of the 43 patients who presented with joint symptoms, nine had mon- articular arthritis, usually of the knee, and this often led to an initial erroneous diagnosis of tuberculous arthritis [a mistake too often made, either because a tuberculin test is not performed or a negative result is ignored].Of the remaining seven patients, four pre- sented with undiagnosed fever, one with a rash, one with recurrent lymphadenopathy, and one with recurrent pneumonitis and a rash.Eventually polyarthritis occurred in all fifty cases; rash, lymphadenopathy, and splenomegaly were noted in eighteen, sixteen, and eight patients respectively.There were four cases of pericarditis and two patients had iridocyclitis, one of whom became blind.Prolonged periodic fever occurred in 31 cases, leading to much general deterioration.Anaemia and leucocytosis were common.The response to the Waaler-Rose test was invariably negative.
Inter-American Society for Chemotherapy, Inc., Annual Conference
Journal: JNCI Journal of the National Cancer Institute (1986)

Inter-American Society for Chemotherapy, Inc., Annual Conference Get access JNCI: Journal of the National Cancer Institute, Volume 77, Issue 4, October 1986, Page 991, https://doi.org/10.1093/jnci/77.4.991-b Published: 01 October 1986
PLEURAL EFFUSION
Authors: L. S. T. Burrell
Journal: BMJ (1931)

thrombosis.It is remarkable, too, that a glycosuria so severe as to require 40 units of insulin per diem for its control should have cleared up in spite of progressive deterioration in the state of the cardio-vascular system.This is all the more surprising when it is remembered that during the patient's first residence in hospital the blood sugar had been well above the limits of normal, and that at post-mortem examination the pancreas was found to be shrunken and fibrosed.It seems possible that these variations in the carbohydrate metabolism may have been related to the chronic inflammation which was present in the biliary tract and to the pathological state of the kidneys.SUMMARY 1.A -case is described in which syphilitic aortitis, coronary thrombosis, and extensive myocardial infarctions were associated with glycosuria and hyperglycaemia.2. Widespread atheroma with degenerative and fibrotic changes in the kidneys and pancreas and chronic inflammation in the biliary tract were found at necropsy in addition to the cardiac lesions.3. The relationship between glycosuria and coronary thrombosis is discussed.It is considered more probable that these two conditions result from a common cause (vascular degeneration) than that glycosuria is an etio- logical factor in the production of coronary thrombosis.I wish to thank Professor W. K.
City Oasis
Authors: OTTO APPENZELLER
Journal: Annals of Internal Medicine (1980)

Ad Libitum1 February 1980City OasisOTTO APPENZELLER, M.D., PH.D.OTTO APPENZELLER, M.D., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-2-259_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptI left in the morning on the usual flight to Chicago. Hostesses looking very much alike served a ghastly meal, making sure that two hours later I arrived with indigestion for a meeting of an advisory group of a government agency. I was convinced that those with whom I was to work would be hostile. I disliked some of their precirculated, well-polished contributions to the day's activities and was sure that they in turn disliked mine.It took only ten minutes to the hotel by "Courtesy Limousine." Police whistles, sirens, and horns were only slightly damped by a blanket of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Albuquerque, New Mexico PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1980Volume 92, Issue 2_Part_1Page: 259-259 ePublished: 1 December 2008 Issue Published: 1 February 1980 PDF downloadLoading ...
Spinal Anesthesia
Authors: Fred J. Spielman
Journal: JAMA (1983)

SINCE its introduction by August Bier in 1898, subarachnoid spinal anesthesia has provoked more continuous controversy than any other anesthetic technique. The very mention of the procedure elicits a stress response from our patients and colleagues as they recall reports of complications ranging in severity from unremitting headache to irreversible paralysis after subarachnoid block. However, this relatively simple procedure is widely employed because of the excellent analgesia and muscle relaxation it provides and the absence of respiratory tract irritation and cardiac depression associated with its use in controlled situations. Spinal anesthesia results from the temporary interruption of nerve transmission after injection of a local anesthetic solution into the subarachnoid space. The local anesthetic agents act on the spinal nerve roots and, possibly, the posterior and lateral areas of the spinal cord.<sup>1</sup>The rapidity of the onset of anesthesia is related to the diameter of nerve fibers. The smallest fibers
Intramuscular injections.
Authors: T. C. Dann
Journal: BMJ (1968)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Intramuscular injections. Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Impact of electronic prescribing on issued and filled opioid prescriptions following Mohs micrographic surgery
Authors: Leora Aizman, Surya A. Veerabagu, Brian Cheng, Allison M. Perz, Tess M. Lukowiak, Jeremy R. Etzkorn, Christopher J. Miller, Thuzar M. Shin, Joseph F. Sobanko, H. William Higgins, Stacy L. McMurray, Joanna L. Walker, Cerrene N. Giordano
Journal: Journal of the American Academy of Dermatology (2022)
Correction: Non-steroidal anti-inflammatory drugs and peptic ulcers
Journal: BMJ (1990)

ulcers.Most patients simply have unsightly veins, heaviness and aching of the legs, or mild ankle swelling; they need to be reassured that their condition is medically harmless, and some will then decide against active treatment.4Some opt for support stockings, which are effective in relieving heaviness and aching.6Most, however, find conservative management unacceptable; they want to be rid of their veins.Careful assessment is imporant for patients who want treatment.Ordinary clinical examination may be adequate, but most vascular surgeons now use a Doppler ultrasound probe to listen to the flow in the veins during manoeuvres such as calf squeezing, the Trendelenberg test, and removal of venous tourniquets.7'0The Doppler probe is particularly helpful in examining the short saphenous system" and recurrent varicose veins.7The aim is to detect incompetence of values between the deep venoussystem and the varicose veins.Incompetent valves occur most commonly at the saphenofemoral junction in the groin, but they also occur in the short saphenous vein behind the knee and in the direct perforating veins in the calf or thigh.If these are not identified and dealt with the varicosities will recur.7 1213 Other methods ofassessing the veins'-such as venography or venous function tests -are not usually necessary for simple varicose veins but may be needed when there is a history ofdeep vein thrombosis, calf perforator incompetence, or surgery.7 12
ELECTROPHYSIOLOGIC PROPERTIES OF HEART BLOCK INDUCED BY IMMUNE CHECKPOINT INHIBITOR MYOCARDITIS FROM CEMIPLIMAB
Authors: Kaustav P. Shah, Akintunde O. Akinkuolie, Heajung L. Nguyen, Carlos Macias, Benjamin Puliafito, David D. Kim, Solomon I. Hamburg, Eric H. Yang, Megan Y. Kamath
Journal: JACC CardioOncology (2022)