tbuckley/cabot-search huggingface dataset:
Diastolic murmurs in the presence of Starr-Edwards mitral prosthesis.
Authors: R ASchaffer, J HMcAnulty, AStarr, S HRahimtoola
Journal: Circulation (1975)

Diastolic murmurs associated with the Starr-Edwards mitral prosthesis have not been described previously. In this report, five patients with mitral prostheses are described in whom apical mid-diastolic and presystolic murmurs resulted from two different causes. Three patients had clots obstructing the prosthetic orifice. The other two had normally functioning protheses and moderately severe aortic insufficiency. The occurrence of mid-diastolic and presystolic murmurs in the presence of a normally functioning prosthetic mitral valve demonstrates that 1) the mid-diastolic Austin Flint murmur can occur in the absence of incomplete mitral valve opening, premature mitral valve closure, vibrating mitral leaflets, or relative mitral stenosis and 2) the presystolic Austin Flint murmur can occur in the absence of incomplete valve opening or presystolic mitral regurgitation. However, the presystolic murmur was associated with early closure movement of the presthetic poppet.
Gene expression of the cardiac Na(+)-Ca2+ exchanger in end-stage human heart failure.
Authors: RStuder, HReinecke, JBilger, TEschenhagen, MBöhm, GHasenfuss, HJust, JHoltz, HDrexler
Journal: Circulation Research (1994)

The regulation of cytosolic Ca2+ concentration during excitation-contraction coupling is altered in the failing human heart. Previous studies have focused on disturbances in Ca2+ release and reuptake from the sarcoplasmic reticulum (SR), whereas functional studies of the cardiac Na(+)-Ca2+ exchanger, another important determinant of myocyte homeostasis, are lacking for the failing human heart. Using a cardiac Na(+)-Ca2+ exchanger cDNA recently cloned from a guinea pig cDNA library, we investigated the gene expression of the cardiac Na(+)-Ca2+ exchanger in relation to the SR Ca(2+)-ATPase. Expression of both genes was quantified in left ventricular myocardium from 24 failing human cardiac explants and 7 control heart samples in relation to beta-myosin heavy chain mRNA by slot blot analysis. Compared with patients with nonfailing hearts, patients with dilated cardiomyopathy (DCM, n = 13) showed a 55% increase in Na(+)-Ca2+ exchanger mRNA levels (P < .05 versus control value) and a 41% increase in patients w...
Electrical stimulation of muscles replaces braces for scoliosis
Authors: C. Macek
Journal: JAMA (1982)

Until recently, a child with progressive scoliosis faced either years of treatment with a brace or major corrective surgery. Now two orthopedic research teams have limited the progression of scoliosis and sometimes actually reduced curvatures by using intermittent muscle contraction induced by electrical stimulation. Walter P. Bobechko, MD, chief of orthopedic surgery at the Hospital for Sick Children, Toronto, accomplishes this by implanting into the subcutaneous tissue of the back a small batteryless receiver whose leads impinge on the deep paraspinal muscles on the convex part of the curve. A bedside radio transmitter activates the internal device, and treatment occurs only when the child is asleep. A research team at Rancho Los Amigos Rehabilitation Engineering Center in Downey, Calif, headed by orthopedist John C. Brown, MD, favors instead external electrical stimulation of the lateral spinal musculature to achieve the same result. In this technique, two electrode disks connected to a
Reversion of cardiac hypertrophy and reduced arterial compliance after converting enzyme inhibition in essential hypertension.
Authors: R GAsmar, BPannier, J PSantoni, SLaurent, G MLondon, B ILevy, M ESafar
Journal: Circulation (1988)

Blood pressure, forearm arterial hemodynamics (with a pulsed Doppler flowmeter), and echocardiographic parameters were studied in 16 patients with sustained essential hypertension before and 3 months after administration of the converting enzyme inhibitor perindopril. In a single-blind study versus placebo, it was shown that perindopril significantly reduced blood pressure (p less than 0.01), whereas there was an increase in brachial blood flow (p less than 0.01) because of a simultaneous increase in blood flow velocity (p less than 0.01) and arterial diameter (p less than 0.01). During a 5-minute period of wrist occlusion, blood flow velocity was reduced to a greater extent with perindopril than with placebo (p less than 0.001), whereas corresponding reductions in arterial diameter were equivalent, indicating that the increase in diameter after perindopril could not be explained simply on the basis of flow-dependent dilatation. During active treatment, brachial artery compliance increased (p less than 0....
FOSL1 promotes metastasis of head and neck squamous cell carcinoma through super-enhancer-driven transcription program
Authors: Ming Zhang, Rosalie G. Hoyle, Zhikun Ma, Bo Sun, Weixin Cai, Hongshi Cai, Nan Xie, Yadong Zhang, Jinsong Hou, Xiqiang Liu, Demeng Chen, Glen E. Kellogg, Hisashi Harada, Yue Sun, Cheng Wang, Jiong Li
Journal: Molecular Therapy (2021)

Previously, we discovered that FOSL1 facilitates the metastasis of head and neck squamous cell carcinoma (HNSCC) cancer stem cells in a spontaneous mouse model. However, the molecular mechanisms remained unclear. Here, we demonstrated that FOSL1 serves as the dominant activating protein 1 (AP1) family member and is significantly upregulated in HNSCC tumor tissues and correlated with metastasis of HNSCC. Mechanistically, FOSL1 exerts its function in promoting tumorigenicity and metastasis predominantly via selective association with Mediators to establish super-enhancers (SEs) at a cohort of cancer stemness and pro-metastatic genes, such as SNAI2 and FOSL1 itself. Depletion of FOSL1 led to disruption of SEs and expression inhibition of these key oncogenes, which resulted in the suppression of tumor initiation and metastasis. We also revealed that the abundance of FOSL1 is positively associated with the abundance of SNAI2 in HNSCC and the high expression levels of FOSL1 and SNAI2 are associated with short overall disease-free survival. Finally, the administration of the FOSL1 inhibitor SR11302 significantly suppressed tumor growth and lymph node metastasis of HNSCC in a patient-derived xenograft model. These findings indicate that FOSL1 is a master regulator that promotes the metastasis of HNSCC through a SE-driven transcription program that may represent an attractive target for therapeutic interventions.
Covid-19 vaccination during Ramadan
Authors: Faraz Mughal
Journal: BMJ (2021)

Vaccine hesitancy has been reported among people and healthcare staff from ethnic minorities. 1 This is a serious concern given covid-19 is the largest global public health challenge in recent years.Vaccination offers hope in preventing morbidity and mortality and helps to build community immunity.This year, Ramadan, the month of fasting, spans April to May.People from some ethnic minority backgrounds, such as black, Bangladeshi, and Pakistani, may be more hesitant to receive a covid vaccination because they don't want to compromise their fast.It is important for these groups to know that having vaccines intramuscularly during fasting time (dawn to dusk) does not nullify one's fast and vaccination should not be delayed. 2 Internationally, healthcare advocates need to work with Muslim faith leaders to disseminate this information.Those fasting may also be concerned that potential side effects of vaccination-for example, myalgia, headache, and tiredness-may make it difficult to maintain their fast.Clinicians and covid-19 vaccinators can advise those fasting to drink more clear fluid and take simple analgesia outside of fasting times to mitigate any side effects.FM is funded by a NIHR Doctoral Fellowship (NIHR300957).The opinions of this letter are that of
Bacteria induce skin regeneration via IL-1β signaling
Authors: Gaofeng Wang, Evan Sweren, Haiyun Liu, Eric Wier, Martin P. Alphonse, Ruosi Chen, Nasif Islam, Ang Li, Yingchao Xue, Junjie Chen, Seungman Park, Yun Chen, Sam Lee, Yu Wang, Saifeng Wang, Nate K. Archer, William Andrews, Maureen A. Kane, Erika Dare, Sashank K. Reddy, Zhiqi Hu, Elizabeth A. Grice, Lloyd S. Miller, Luis A. Garza
Journal: Cell Host & Microbe (2021)
Clinical, biochemical, and serologic predictors of drug reaction with eosinophilia and systemic symptoms syndrome: A prospective case–control study
Authors: Rajat Choudhary, Keshavamurthy Vinay, Niharika Srivastava, Anuradha Bishnoi, Divya Kamat, Davinder Parsad, Alka Bhatia, Muthu Sendhil Kumaran
Journal: Journal of the American Academy of Dermatology (2021)
Total anomalous pulmonary venous connection and severe pulmonic stenosis in a 52-year-old man.
Authors: J OPastore, C WAkins, L MZir, M JBuckley, R EDinsmore
Journal: Circulation (1977)

Total anomalous pulmonary venous connection (TAPVC) is a rare cardiac congenital abnormality which usually results in death in infancy or early childhood. We describe a 52-year-old man with TAPVC and severe calcific pulmonic stenosis. Both diagnoses were suspected clinically and from the chest X-ray. Cardiac catheterization was confirmatory, and the patient underwent surgery. His initial postoperative course has been unremarkable. The hemodynamic factors relevant to long survival and relative freedom from symptoms in TAPVC are considered based on findings in this patient.
Endoscopic Submucosal Dissection: Recurrence Among R0 Resections… How to Explain?
Authors: M Rodríguez-Carrasco, D Libânio, P Pimentel-Nunes, LP Afonso, P Monterio, M Dinis-Ribeiro
Journal: Endoscopy (2021)

Aims Endoscopic submucosal dissection (ESD) is a well-established procedure for the treatment of early gastric cancer in Eastern countries. However, this technique has not been yet widely implemented in western centres due to its higher risk of complications and worse outcomes compared to expert-Eastern centres. We aimed to assess safety, oncological outcomes of ESD, and risk factors for local recurrence.
Monitoring Warfarin Therapy in Patients with Lupus Anticoagulants
Authors: Arumugam Manoharan
Journal: Annals of Internal Medicine (1998)

Letters15 March 1998Monitoring Warfarin Therapy in Patients with Lupus AnticoagulantsArumugam Manoharan, MDArumugam Manoharan, MDSt. George Hospital; Kogarah, Sydney, AustraliaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-6-199803150-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Moll and Ortel [1] raise an important clinical management issue: Use of international normalized ratios may not be a reliable way to monitor warfarin therapy in some patients with lupus anticoagulants. In a report published 20 years ago [2], my colleagues and I documented the use of the “Thrombotest” [3] in a patient with lupus anticoagulant. Because this test measured overall clotting activity and the result was expressed as percentage of activity [4], we thought that it was better for monitoring oral anticoagulant therapy than the conventional prothrombin time in patients with lupus anticoagulants. Can Drs. Moll ...References1. Moll S, Ortel TL. Monitoring warfarin therapy in patients with lupus anticoagulants. Ann Intern Med. 1997; 127:177-85. Google Scholar2. Manoharan A, Gibson L, Rush B, Feery BJ. Recurrent venous thrombosis with a “lupus” coagulation inhibitor in the absence of systemic lupus. Aust N Z J Med. 1977; 7:422-6. Google Scholar3. Owren PA. Thrombotest. A new method for controlling anticoagulant therapy. Lancet. 1959; 2:754-8. Google Scholar4. Pitney WR. Oral anticoagulants. In: Clinical Aspects of Thromboembolism. London: Churchill Livingstone; 1972:80-107. Google Scholar Author, Article, and Disclosure InformationAffiliations: St. George Hospital; Kogarah, Sydney, Australia PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 March 1998Volume 128, Issue 6Page: 504KeywordsAnticoagulant therapyAnticoagulantsInternational normalized ratioProthrombin time Issue Published: 15 March 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Effect of postganglionic vagal stimulation on the organization of atrioventricular nodal conduction in isolated rabbit heart tissue.
Authors: TMazgalev, L SDreifus, E LMichelson, APelleg
Journal: Circulation (1986)

Postganglionic stimulation of vagal terminals (PGVS) in the isolated rabbit heart atrioventricular (AV) node was used to study the effects of cholinergic influence on AV nodal conduction. Standard microelectrode techniques were used to record action potentials, predominantly from cells located in the N region of the AV node. In addition, programmed stimulation was used in conjunction with PGVS to initiate or terminate AVN reentry. The introduction of a single short burst of PGVS (total duration 50 to 100 msec, impulse duration 1 msec, and interimpulse interval 6 msec) with subthreshold amplitude for AV node fibers caused reproducible disorganization of the prevailing excitation front. This was manifest as local nonuniform depression of conduction, hump formations in the action potentials, and alteration in the sequence of depolarization. The introduction of repetitive bursts of PGVS revealed a triphasic time course of changes in AV nodal conduction time, representing initial maximal prolongation, relative...
Electrophysiological response of vascularized hamster cardiac transplants to ischemia.
Authors: R FGilmour, D PZipes
Journal: Circulation Research (1982)

To study transmembrane electrophysiological properties of blood-perfused mammalian heart cells during normal perfusion and during acute ischemia, 1- to 2-mm cubes of neonatal hamster atrial and ventricular myocardium were transplanted to the adult hamster cheek pouch and studied with microelectrodes 4--7 days later, when vascularization and spontaneous contractions occurred. Action potentials recorded from the transplants were similar to those recorded from neonatal and adult hamster myocardium studied in vitro. Interrupting blood flow to spontaneously beating transplants reduced diastolic depolarization and suppressed automaticity. After automaticity ceased, the transplants were paced with a bipolar electrode or intracellular microelectrode. Action potential amplitude, resting potential, and dV/dtmax decreased during ischemia. Action potential duration and the intracellular current threshold for excitation increased initially, subsequently decreased to values less than control, and increased again prior ...
Histopathology of the conduction system in sudden death from coronary heart disease.
Authors: J TLie
Journal: Circulation (1975)

Sudden cardiac death (SCD) has been attributed to the development of lethal dysrhythmias in coronary heart disease victims, and several recent autopsy surveys showed that 10 to 50% of SCD patients had unsuspected acute myocardial infarction (AMI). The present study concerned histopathological findings of the conduction system in 49 SCD (within six hours of the onset of acute symptoms) patients; 39 with established AMI (group A) and ten without (group B). Both groups showed high incidence of cardiomegaly, significant coronary artery disease affecting one or more vessels, and acute myocardial ischemia detectable by specific histological criteria. Stenosis of nutrient vessels of the conduction system was present in about 50% of the atrioventricular (A-V) node arteries and about 25% of the sinoatrial (SA) node arteries in both groups of SCD patients. Nonspecific degenerative changes (fibrosis, fatty infiltration, or both) of the conduction tissue, which might or might not represent results of old ischemic i...
67P Clinical outcomes of resected EGFR positive stage I-III NSCLC patients in the Midlands, UK
Authors: R.L. Powell, N. Murukesh, P. Seeva, A. Solanki, A. Singh, A. Jain, A.R. Elmasry, A. Jegannathen, A. Irwin, Q. Ghafoor, B. O'Sullivan, P. Taniere, S. Baijal
Journal: Journal of Thoracic Oncology (2021)
Platelet activating factor: a potent constrictor of cerebral arterioles in newborn pigs.
Authors: W MArmstead, MPourcyrous, RMirro, C WLeffler, D WBusija
Journal: Circulation Research (1988)

This study characterized the nature of the response to platelet activating factor (PAF) in the cerebral microcirculation of the newborn pig. Pial arterioles were observed directly using a closed cranial window in chloralose-anesthetized piglets. Topical application of 10-100 ng/ml PAF produced dose-dependent decreases in pial arteriolar diameter; diameters were 193 +/- 27 microns for control, 167 +/- 25 microns at 10 ng/ml, and 129 +/- 21 microns at 100 ng/ml. Topical application of 30-300 ng/ml norepinephrine and 3-30 ng/ml U46619, a purported thromboxane A2 receptor agonist, also produced dose-dependent decreases in pial arteriolar diameter. After topical administration of U66985 (1 microgram/ml), a putative PAF antagonist, responses to PAF were attenuated significantly, but responses to norepinephrine and U46619 were unchanged. Moreover, intravenously administered U66985 (0.1 mg/kg) antagonized PAF responses as well. Responses to PAF were unchanged after cyclooxygenase and leukotriene receptor inhibiti...
Hemosuccus Pancreaticus (HP), An Uncommon Case Report Of Upper Gastrointestinal Bleeding (UGIB)
Authors: O Labianca, M Sica, C Zulli, A Maurano
Journal: Endoscopy (2021)

Aims Hemosuccus pancreaticus (HP) is a rare and potentially life-threatening upper gastrointestinal bleeding (UGIB) from the ampulla of Vater, usually caused by rupture of a visceral psuedoaneurysm of a peripancreatic vessel through the main pancreatic duct, or by a pancreatic psuedocyst in the context of acute or chronic pancreatitis.
Developmental hemodynamic changes in the chick embryo from stage 18 to 27.
Authors: E BClark, NHu
Journal: Circulation Research (1982)

We report the hemodynamic parameters of stage 18, 21, 24, and 27 chick embryos (from 3 to 5 days of incubation). Dorsal aortic blood velocity and mean vitelline artery blood pressure are measured with a 20 MHz pulsed-Doppler meter and servo-null pressure system respectively. We also measure heart rate, dorsal aortic diameter and embryo weight of each developmental stage. From these data, we calculate mean dorsal aortic blood flow, mean dorsal aortic blood flow per cardiac cycle, mean dorsal aortic blood flow per milligram embryo weight, vascular resistance and cardiac work. Blood flow increases geometrically with each embryo stage but remains constant when normalized for embryo weight. Mean arterial pressure increases linearly and vascular resistance decreases geometrically. Cardiac work increases in proportion to embryo weight. These results define the parameters of normal hemodynamic function during early embryonic development.
Mechanism for the postive inotropic effect of angiotensin II on isolated cardiac muscle.
Authors: R JFreer, A JPappano, M JPeach, K TBing, M JMcLean, SVogel, NSperelakis
Journal: Circulation Research (1976)

Angiotensin II (A II) and analogues were tested for their ability to restore electrical and mechanical activity to cardiac muscle preparations in which the fast Na+ channels had been inactivated by partial depolarization (22-27 mM K+) or by tetrodotoxin (TTX). The partially depolarized or TTX-blocked preparations were chosen because under these conditions electrical and mechanical responses are primarily Ca2+ -dependent. In depolarized rabbit right atria, A II restored spontaneous mechanical and electrical activity (measured by both intracellular and extracellular recording techniques). The frequency of action potential discharge was concentration-dependent; the threshold concentration of A II was 10(-10) M, the ED50 was 8 X 10(-9) M, and the maximum effect was observed at 5 X 10(-8) M. In contrast, depolarized guinea pig atria were insensitive to A II, Sar1-angiotensin II, and des-Asp1-angiotensin II, even at concentrations as high as 10(-5) M. Rabbit papillary muscle (TTX-blocked), embryonic (18-day) ch...
Catenoid shape of the interventricular septum: possible cause of idiopathic hypertrophic subaortic stenosis.
Authors: G MHutchins, B HBulkley
Journal: Circulation (1978)

Previous studies have shown that asymmetric septal hypertrophy (ASH) may occur in embryonic and malformed hearts and that muscle cell disarray is found in myocardium that contracts isometrically. To account for the characteristic ASH and septal muscle fiber disarray of idiopathic hypertrophic subaortic stenosis (IHSS), we postulated that a catenoid shape of the septum, i.e., net zero curvature, would have the mechanics required to produce IHSS. Accordingly, hearts from eight autopsied patients with IHSS were studied for curvature and thickness of free walls and septum, and they were compared to similar measurements in 80 other hearts. In all eight hearts with IHSS the septum was concave to the left in the transverse plane but convex to the left in the apex-to-base plane. Such a catenoid configuration of the septum was not observed in any of the other 80 hearts. The distinctive shape of the septum in IHSS would account for isometric contraction, since adjacent fiber tracts with opposite curvatures would de...
Inhibition of the in vitro renin reaction by circulating neutral lipids.
Authors: T AKotchen, R TTalwalkar, W JWelch
Journal: Circulation Research (1977)

We have previously reported that the addition of plasma from normotensive human subjects to renin-renin substrate inhibits the in vitro rate of angiotensin generation. The purpose of the present study was to determine whether a renin-inhibiting factor could be identified in human plasma. Neutral lipids and phospholipids were extracted from plasma of seven normotensive control subjects. During 30-, 60-, and 180-minute incubations, neutral lipids inhibited the reaction between human renin and homologous renin substrate (P less than 0.01). Phospholipids did not affect the rate of angiotensin generation (P less than 0.05). The neutral lipid extract was further separated on silica gel chromatographic plates, and several fractions inhibited renin (P less than 0.01) Addition of each of six synthetic neutral lipids to renin-renin substrate did not affect the rate of angiotensin generation. In conclusion, several neutral lipid fractions extracted from human plasma inhibit the in vitro renin reaction.
Stress echocardiography with transesophageal atrial pacing: preliminary report of a new method for detection of ischemic wall motion abnormalities.
Authors: P DChapman, T PDoyle, P JTroup, C MGross, L SWann
Journal: Circulation (1984)

We performed two-dimensional echocardiography in 19 patients with significant coronary artery disease and in six normal volunteers at rest and during transesophageal atrial pacing. Technically adequate resting echocardiograms were obtained in 18 of the 19 patients and in all six normal volunteers. In two subjects, atrial capture was not possible, and in one subject, discomfort from the pacing at the beginning of the study precluded its completion. In all subjects (n = 21) who completed the protocol satisfactory two-dimensional echocardiograms were obtained during pacing. Wall motion was normal at rest and during atrial pacing in five normal volunteers. New transient wall motion abnormalities developed in 13 of the 16 patients during pacing. Twelve of the 13 patients had significant coronary lesions in the coronary arteries supplying the abnormal wall segment. Only three of the patients developed significant ST segment depression during pacing. We conclude that stress echocardiography with transesophageal ...