tbuckley/cabot-search huggingface dataset:
Biomimetic Metal−Organic Frameworks as Targeted Vehicles to Enhance Osteogenesis
Authors: Na Liang, Na Ren, Zhichao Feng, Zhaoyang Sun, Mengwei Dong, Wenhan Wang, Feng Liu, Chunhui Sun, Weijia Zhou, Zhiqing Xing, Jingang Wang, Chao Liu, Hong Liu
Journal: Advanced Healthcare Materials (2022)

Abstract Although engineered nanoparticles loaded with specific growth factors are used to regulate differentiation of stem cells, the low loading efficiency and biocompatibility are still great challenges in tissue repair. A nature‐inspired biomimetic delivery system with targeted functions is attractive for enhancing cell activity and controlling cell fate. Herein, a stem cell membrane (SCM)‐wrapped dexamethasone (DEX)‐loaded zeolitic imidazolate framework‐8 (ZIF‐8) is constructed, which integrates the synthetic nanomaterials with native plasma membrane, to achieve efficient DEX delivery and DEX‐mediated bone repair. The DEX@ZIF‐8‐SCM enables high DEX loading capacity, modulates the sustained release, and facilitates the specific uptake of mesenchymal stem cells (MSCs), owing to the porous property of ZIF‐8 and the innate targeting capability of SCM. The endocytosed DEX@ZIF‐8‐SCM shows high cytocompatibility and greatly enhances the osteogenic differentiation of MSCs. Furthermore, RNA‐sequencing data reveal that the phosphoinositide 3‐kinase (PI3K)‐Akt signaling pathways are activated and dominantly involved in the accelerated osteogenesis. In the bone defect model, the administrated DEX@ZIF‐8‐SCM exerts excellent biocompatibility and effectively promotes bone regeneration. Overall, the SCM‐derived biomimetic nanoplatform achieves targeted delivery, excellent biosafety, and enhanced osteogenic differentiation and bone repair, which provides a new and valid strategy for treating various tissue injuries.
RESEARCH SCHOLARSHIP
Authors: G. Elliston
Journal: BMJ (1906)

the business of getting well is held before the patient as his first duty, and to this every other consideration is subordinated.The cost of the buildings has been defrayed by, public subscription, but the institution is now self-supporting.The payments made by or for patients are as follows: In a single room 5 marks, in a room with two beds 4.50 marks, in a room with four beds 3.50 marks a day.
Irish Workhouse Reform
Authors: W. R. Macdermott
Journal: BMJ (1896)

OUR people are greatly excited just now about atrocities abroad: it would be well if we took some thought of atrocities at home.At p. 14 of the Report of the Local Government Board for 1895 a table is given of the causes of death in the Irish work- houses from March gth, I895, to March 28th, 1896.It is a sig- nificant thing that this table stands year after year in succes- sive reports sometimes much worse, seldom anything better, to find all of us blind to its hideous meaning.It is easy to bring out that meaning; a few figures will do it.In the middle of 1895 the Irish population was 4,574,807.The number of deaths in the year was 84,487, the rate of mortality I8.5 per i,oco per annum.iThe number of deaths in the workhouses in 1895 is given in the Report of the Local Government Board, page 9, as 9,929-- that is, i i.8 per cent. of the whole number of deaths in the
Cosmetic surgery.
Authors: P K Davis
Journal: BMJ (1981)

<h3>ABSTRACT</h3> <h3>OBJECTIVE</h3> To describe the occurrence of mental health problems and cognitive impairment in a group of elderly homeless men and to demonstrate how clinical examination and screening tests used in a shelter setting might be helpful in identifying mental illness and cognitive impairment. <h3>DESIGN</h3> Cross-sectional study including face-to-face interviews and review of medical records. <h3>SETTING</h3> A community-based homeless shelter in an urban metropolitan centre (Toronto, Ont). <h3>PARTICIPANTS</h3> A total of 49 male participants 55 years of age or older. The average duration of homelessness was 8.8 (SD 10.2) years. <h3>METHODS</h3> Participants were admitted to a community-based shelter that offered access to regular meals, personal support and housing workers, nursing, and a primary care physician. Medical chart review was undertaken to identify mental illness or cognitive impairment diagnosed either before or after admission to the facility. The 15-item Geriatric Depression Scale (GDS-15) and the Folstein Mini-Mental State Examination (MMSE) were administered. <h3>MAIN OUTCOME MEASURE</h3> Previous or new diagnosis of mental illness or cognitive impairment. <h3>RESULTS</h3> Thirty-six of the participants (73.5%) had previous or new diagnoses. The most prevalent diagnosis was schizophrenia or psychotic disorders (n = 17), followed by depression (n = 11), anxiety disorders (n = 3), cognitive impairment (n = 8), and bipolar affective disorder (n = 1). A total of 37% of participants were given new mental health diagnoses during the study. The GDS-15 identified 9 people with depression and the MMSE uncovered 11 individuals with cognitive impairment who had not been previously diagnosed. <h3>CONCLUSION</h3> This study suggests that providing access to primary care physicians and other services in a community-based shelter program can assist in identification of mental illness and cognitive impairment in elderly homeless men. Use of brief screening tools for depression and cognitive impairment (like the GDS-15 and the MMSE) could be helpful in this highrisk group.
The Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel
Authors: Tomas Fitzgerald, Ian Brettell, Adrien Leger, Nadeshda Wolf, Natalja Kusminski, Jack Monahan, Carl Barton, Cathrin Herder, Narendar Aadepu, Jakob Gierten, Clara Becker, Omar T. Hammouda, Eva Hasel, Colin Lischik, Katharina Lust, Natalia Sokolova, Risa Suzuki, Erika Tsingos, Tinatini Tavhelidse, Thomas Thumberger, Philip Watson, Bettina Welz, Nadia Khouja, Kiyoshi Naruse, Ewan Birney, Joachim Wittbrodt, Felix Loosli
Journal: Genome biology (2022)

Unraveling the relationship between genetic variation and phenotypic traits remains a fundamental challenge in biology. Mapping variants underlying complex traits while controlling for confounding environmental factors is often problematic. To address this, we establish a vertebrate genetic resource specifically to allow for robust genotype-to-phenotype investigations. The teleost medaka (Oryzias latipes) is an established genetic model system with a long history of genetic research and a high tolerance to inbreeding from the wild.
Laying the Foundation for a New and Inclusive Science
Authors: Benjamin P. Linas, Sabrina A. Assoumou
Journal: JAMA Network Open (2022)

Jenell Stewart, DO, MPH; Meighan L. Krows, BA; Torin T. Schaafsma, MPH; Kate B. Heller, MS; Elizabeth R. Brown, ScD; Jim Boonyaratanakornkit, MD, PhD; Clare E. Brown, MS; Hannah Leingang, MPH; Caroline Liou, MA; Anna Bershteyn, PhD; Mark D. Schwartz, MD; Vaidehi Agrawal, PhD; DeAnna Friedman-Klabanoff, MD; Stephen Eustace, BA; Helen C. Stankiewicz Karita, MD; Michael K. Paasche-Orlow, MD, MA, MPH; Patricia Kissinger, PhD; Sybil G. Hosek, PhD; Helen Y. Chu, MD, MPH; Connie Celum, MD, MPH; Jared M. Baeten, MD, PhD; Anna Wald, MD, MPH; Christine Johnston, MD, MPH; Ruanne V. Barnabas, MBChB, MSc, DPhil
Abstract 150: Impact of Epinephrine on ECG Changes During Resuscitation From Out-of-Hospital Cardiac Arrest With Initial Pulseless Electrical Activity
Authors: Gunnar W Skjeflo, Eirik Skogvoll, Jan Pål Loennechen, Theresa M Olasveengen, Lars Wik, Trond Nordseth
Journal: Circulation (2018)

Introduction: Presence of electrocardiographic rhythm, documented by the electrocardiogram (ECG), in the absence of palpable pulses defines pulseless electrical activity (PEA). Our aims were to examine the development of ECG characteristics during advanced life support (ALS) from Out-of-Hospital-Cardiac-Arrest (OHCA) with initial PEA, and to explore the effects of epinephrine on these characteristics. Methods: Patients with OHCA and initial PEA in a randomized controlled trial of ALS with or without intravenous access and medications were included. QRS widths and heart-rates were measured in recorded ECG signals during pauses in compressions. Statistical analysis was carried out by multivariate regression (MANOVA). Results: Defibrillator recordings from 170 episodes of cardiac arrest were analyzed, 4840 combined measurements of QRS complex width and heart rate were made. By the multivariate regression model both whether epinephrine was administered and whether return of spontaneous circulation (ROSC) was obtained were significantly associated with changes in QRS width and heart rate. For both control and epinephrine groups, ROSC was preceded by decreasing QRS width and increasing rate, but in the epinephrine group an increase in rate without a decrease in QRS width was associated with poor outcome (fig). Conclusion: The QRS complex characteristics are affected by epinephrine administration during ALS, but still yields valuable prognostic information.
FIVE-YEAR PROGNOSTIC VALUE OF NO-REFLOW PHENOMENON AFTER PERCUTANEOUS CORONARY INTERVENTION IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
Authors: Katrin A. Birkmeier, Gjin Ndrepepa, Klaus Tiroch, Julinda Mehilli, Melanie Nordmann, Patricia Alger, Isabell Bernlochner, Rene Vollenbroich, Julia Goedel, Julia Ellert, Adnan Kastrati, Albert Schö;mig, Deutsches Herzzentrum
Journal: Journal of the American College of Cardiology (2010)
American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS–CoV‐2 and Hyperinflammation in Pediatric COVID‐19: Version 3
Authors: Lauren A. Henderson, Scott W. Canna, Kevin G. Friedman, Mark Gorelik, Sivia K. Lapidus, Hamid Bassiri, Edward M. Behrens, Kate F. Kernan, Grant S. Schulert, Philip Seo, Mary Beth F. Son, Adriana H. Tremoulet, Christina VanderPluym, Rae S. M. Yeung, Amy S. Mudano, Amy S. Turner, David R. Karp, Jay J. Mehta
Journal: Arthritis & Rheumatology (2022)

To provide guidance on the management of Multisystem Inflammatory Syndrome in Children (MIS-C), a condition characterized by fever, inflammation, and multiorgan dysfunction that manifests late in the course of SARS-CoV-2 infection. Recommendations are also provided for children with hyperinflammation during COVID-19, the acute, infectious phase of SARS-CoV-2 infection.The Task Force is composed of 9 pediatric rheumatologists and 2 adult rheumatologists, 2 pediatric cardiologists, 2 pediatric infectious disease specialists, and 1 pediatric critical care physician. Preliminary statements addressing clinical questions related to MIS-C and hyperinflammation in COVID-19 were developed based on evidence reports. Consensus was built through a modified Delphi process that involved anonymous voting and webinar discussion. A 9-point scale was used to determine the appropriateness of each statement (median scores of 1-3 for inappropriate, 4-6 for uncertain, and 7-9 for appropriate). Consensus was rated as low, moderate, or high based on dispersion of the votes. Approved guidance statements were those that were classified as appropriate with moderate or high levels of consensus, which were prespecified before voting.The guidance was approved in June 2020 and updated in November 2020 and October 2021, and consists of 41 final guidance statements accompanied by flow diagrams depicting the diagnostic pathway for MIS-C and recommendations for initial immunomodulatory treatment of MIS-C.Our understanding of SARS-CoV-2-related syndromes in the pediatric population continues to evolve. This guidance document reflects currently available evidence coupled with expert opinion, and will be revised as further evidence becomes available.
THE RELATION OF LABYRINTHINE TONUS TO MUSCLE TONUS
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bilharzia Haematobia
Authors: W. K. Hatch
Journal: BMJ (1878)

or of the sacro-iliac articulation, and its very essence is the eliciting of pain.Now, I will proceed to demonstrate that peculiar flattening of the buttock, the obliteration of the firrm natal fold, and the alteration of its level, together with the real (not apparent) widening of the hip.To this interesting point my attention was directed by my friend Mr. Herbert Page, who was examining this preparation with me.For this purpose, I remove the syringe from the India-rubber pipe and sub- stitute a vertical glass tube, the joint being full of water which rises to this (indicated) level in the tube.Now, I press the great trochanter inwards, driving the head of the femur into the acetabulum ; see how the fluid rises in the tube.Then I remit pressure; the joint fills again, and the great trochanter is forced outwards.Treatment.-Lastly,we come to the question of treatment of hip- joint disease; but, before discussing it, I would like to demonstrate the effect of' extension and counter-extension upon the preparation.When the limb is brought down (no matter by what means), the intra- articular pressure is increased.The anterior part-of the capsule being renderel tense, the capacity of the joint is diminished.The more the limb is brought down to the straight, the further the head of the femur is forced up into the acetabulum.This I demonstrate by the rise and fall of the water in the vertical tube corresponding to depression and flexion of the femur.
CEREBRO-SPINAL MENINGITIS: DIAGNOSIS AND PROPHYLAXIS
Authors: A. Lundie, D. J. Thomas, S. Fleming
Journal: BMJ (1915)

an examiniation of all the mnen wio sle] (CIIEI3R1BRO-SPINA-L M INGI TIS as the patienlt for several nights before hieavrd of a case anywvhero, we proc D;IAGaNOSIS AND -PIOPHYLXXIS.having malde tllh followin ang6m]number of West's swabs in a case. .Ti A ' .B E Ewires, thlinnued at thle distal eind ancd si 31.B, `CHA'.BEDEN.. to make tlhem hold the
Paediatric hospitalisations due to COVID-19 during the first SARS-CoV-2 omicron (B.1.1.529) variant wave in South Africa: a multicentre observational study
Authors: Jeané Cloete, Annelet Kruger, Maureen Masha, Nicolette M du Plessis, Dini Mawela, Mphailele Tshukudu, Tabea Manyane, Lekwetji Komane, Marietjie Venter, Waasila Jassat, Ameena Goga, Ute Feucht
Journal: The Lancet Child & Adolescent Health (2022)
Practice patterns in the management of metastatic castration-sensitive prostate cancer: A single-center survey-based study.
Authors: Eric Lu, Xiaoyan Wang, John Shen
Journal: Journal of Clinical Oncology (2022)

45 Background: Advanced hormonal therapies (abiraterone, enzalutamide, apalutamide) and docetaxel have demonstrated an overall survival benefit when added to androgen deprivation therapy (ADT) for metastatic castration-sensitive prostate cancer (mCSPC). There are no randomized controlled trials comparing these agents, resulting in heterogeneity in first-line therapy and sequencing of therapies. Methods: We surveyed practice patterns and underlying rationale behind first-line therapy selection for mCSPC among medical and urologic oncologists at a single center (academic and community-based practices). Responses were anonymous. We evaluated associations between responses using Friedman’s test with posthoc pair-wise comparison and Fisher exact test where appropriate. Results: From 6/2021-8/2021, we received 72/77 (94%) of distributed surveys. Of the 72 providers, 39 (31 med/onc, 8 uro/onc) reported treating mCSPC. For high-volume disease, most selected ADT plus docetaxel (41%) as first-line therapy. For low-volume disease, most selected ADT plus abiraterone (31%). There continues to be the use of bicalutamide in the treatment of low-volume mCSPC (18%). When asked to rank the most important factors when considering first-line therapy, clinical symptoms (skeletal event, bone pain, anorexia, weight loss, fatigue, visceral metastases) and disease volume were ranked higher than cost for both oncologists (p&lt;0.01) and urologists (p = 0.03 for symptoms vs. cost and p&lt;0.01 for disease volume vs. cost). When considering perceived barriers to selecting first-line therapy, 64% of providers identified out-of-pocket costs. Although uro/onc was less comfortable managing side effects of docetaxel compared to med/onc (0% vs. 100% comfortable, p&lt;0.01), comfort levels with managing toxicities of hormonal therapies were comparable (100% vs. 97% comfortable, p=0.54). Conclusions: Given limitations of cross-trial comparison of efficacy from registration trials, the selection of front-line therapy for mCSPC often depends on shared decision-making. By this survey-based study, we observed docetaxel being favored for high-volume disease and abiraterone being favored for low-volume disease. Although cost did not factor into the selection of therapy, it was cited as the most common barrier faced by providers. [Table: see text]
Oral contraceptives and thromboembolism.
Journal: BMJ (1968)

PointersThromboembolism and the "Pill": "Strong relation " found between use of oral contraceptives and death from pulmonary embolism or cerebral thrombosis but not coronary throm- bosis.Risk unrelated to pill formula (p. 193).Hospital study shows venous thromboembolism to be about nine times more frequent in patients on oral contraceptives than in controls (p.199) ; Leader this page.Scintillation Scanning: Useful in diagnosis of pulmonary embolism and helpful in assessing effectiveness of anticoagulant or thrombolytic therapy (p.206).Unexpected abnormalities of perfusion found on scanning in one-third of a group of 50 patients with bronchial carcinoma (p.209).Intractable Pain: Percutaneous electrical cord- otomy proved simple and efficacious in relieving pain in majority of a series of cases, particularly in patients with terminal disease (p.210).Atrial Fibrillation: Propranolol slowed ventric- ular rate in four cases of chronic valvar disease not amenable to digitalis, but it also produced heart failure (p.213).Vitamin B12 and Smoking: Further evidence pointing to disturbance of B12 metabolism by smoking (p.215).Drugs and the Thyroid: Studies of depressant and antidepressant drugs in hyperthyroid mice suggest that safety margin of phenothiazines may be reduced in thyrotoxicosis (p.217).Peritonitis: Experimental study of continuous peritoneal lkvage (p.219).Liver Transplantation: Warming up of porcine hepatic transplant during operation can result in ischaemic damage which is preventable by use of an insulator (p.220).Case Reports: Lignocaine in atrial flutter (p. 223); paraquat and ocular damage (p.224).Malabsorption: Clinical syndromes and their treatment (p.225)." Medicine Today": Neonatal respiratory dis- orders (p.228).Tranquillizers: Drugs in current use (p.230).
Operational tolerance after hematopoietic stem cell transplantation is characterized by distinct transcriptional, phenotypic, and metabolic signatures
Authors: Laetitia Dubouchet, Helena Todorov, Ruth Seurinck, Nicolas Vallet, Sofie Van Gassen, Aurélien Corneau, Catherine Blanc, Habib Zouali, Anne Boland, Jean-François Deleuze, Brian Ingram, Regis Peffault de Latour, Yvan Saeys, Gérard Socié, David Michonneau
Journal: Science Translational Medicine (2022)

The mechanisms underlying operational tolerance after hematopoietic stem cell transplantation in humans are poorly understood. We studied two independent cohorts of patients who underwent allogeneic hematopoietic stem cell transplantation from human leukocyte antigen–identical siblings. Primary tolerance was associated with long-lasting reshaping of the recipients’ immune system compared to their healthy donors with an increased proportion of regulatory T cell subsets and decreased T cell activation, proliferation, and migration. Transcriptomics profiles also identified a role for nicotinamide adenine dinucleotide biosynthesis in the regulation of immune cell functions. We then compared individuals with operational tolerance and nontolerant recipients at the phenotypic, transcriptomic, and metabolomic level. We observed alterations centered on CD38 + -activated T and B cells in nontolerant patients. In tolerant patients, cell subsets with regulatory functions were prominent. RNA sequencing analyses highlighted modifications in the tolerant patients’ transcriptomic profiles, particularly with overexpression of the ectoenzyme NT5E (encoding CD73), which could counterbalance CD38 enzymatic functions by producing adenosine. Further, metabolomic analyses suggested a central role of androgens in establishing operational tolerance. These data were confirmed using an integrative approach to evaluating the immune landscape associated with operational tolerance. Thus, balance between a CD38-activated immune state and CD73-related production of adenosine may be a key regulator of operational tolerance.
4. Comprehensive Medical Evaluation and Assessment of Comorbidities:<i>Standards of Medical Care in Diabetes—2019</i>
Journal: Diabetes Care (2018)

The American Diabetes Association (ADA) “Standards of Medical Care in Diabetes” includes ADA’s current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, a multidisciplinary expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA’s clinical practice recommendations, please refer to the Standards of Care Introduction. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
CD301b+ macrophages mediate angiogenesis of calcium phosphate bioceramics by CaN/NFATc1/VEGF axis
Authors: Jiaolong Wang, Qin Zhao, Liangliang Fu, Shihang Zheng, Can Wang, Litian Han, Zijian Gong, Ziming Wang, Hua Tang, Yufeng Zhang
Journal: Bioactive Materials (2022)

Calcium phosphate (CaP) bioceramics are important for tissue regeneration and immune response, yet how CaP bioceramics influence these biological processes remains unclear. Recently, the role of immune cells in biomaterial-mediated regeneration, especially macrophages, has been well concerned. CD301b+ macrophages were a new subset of macrophages we have discovered, which were required for bioceramics-mediated bone regeneration. Nevertheless, the impact of CD301b+ macrophages on angiogenesis, which is a vital prerequisite to bone formation is yet indistinct. Herein, we found that CD301b+ macrophages were closely correlated to angiogenesis of CaP bioceramics. Additionally, depletion of CD301b+ macrophages led to the failure of angiogenesis. We showed that store-operated Ca2+ entry and calcineurin signals regulated the VEGF expression of CD301b+ macrophages via the NFATc1/VEGF axis. Inhibition of calcineurin effectively impaired angiogenesis via decreasing the infiltration of CD301b+ macrophages. These findings provided a potential immunomodulatory strategy to optimize the integration of angiogenesis and bone tissue engineering scaffold materials.