tbuckley/cabot-search huggingface dataset:
Hypothyroidism and Depression
Authors: Mark S. Gold
Journal: JAMA (1981)

To evaluate the relationship between hypothyroidism and depression, thyroid function was evaluated in 250 consecutive patients referred to a psychiatric hospital for treatment of depression or anergia. Twenty of the 250 patients had some degree of hypothyroidism. Two patients (less than 1%) were identified with grade 1 (overt); nine patients (3.6%), grade 2 (mild); and ten patients (4%), grade 3 (subclinical) hypothyroidism. These results suggest that a significant proportion of patients with depression and anergia may have early hypothyroidism, the cases of about half of which are detected only by thyrotropin-releasing hormone (TRH) testing. Because hypothyroidism can produce signs and symptoms of depression and can coexist as a second illness in depressed patients, patients with early hypothyroidism may be candidates for thyroid replacement therapy. Clinical examination and measurement of triiodothyronine resin uptake thyroxine and baseline thyroid-stimulating hormone (TSH) levels, and TSH response to TRH are necessary to identify candidates for thyroid replacement among cases diagnosed by descriptive criteria as having either major or minor depression, particularly those that are atypical or treatment resistant. (<i>JAMA</i>1981;245:1919-1922)
Personal View
Authors: T Pace
Journal: BMJ (1989)

A 61-year-old woman who was originally diagnosed with locally advanced adrenocortical carcinoma (ACC) 10 years ago, developed massive haemoptysis while away from the UK. Initial investigations revealed a left upper lobe lesion requiring embolisation. Bronchoscopic evaluation was unsuccessful in identifying an underlying cause, and cytology was suggestive of an inflammatory cause. A rigid bronchoscopy was planned but prior to this the patient coughed up a lump of tissue which was sent for histopathological examination. Morphology and immunohistochemistry were consistent with metastatic ACC. ACC is a rare and aggressive tumour of the adrenal cortex. The histological appearances of ACC are similar to that of a carcinoid tumour, creating diagnostic difficulty given the presumed endobronchial origin of the expectorated material in this case. Accurate clinical information and judicious use of immunohistochemistry were key to making the diagnosis. To the authors knowledge, this is the first described case of expectorated metastatic ACC.
Letter: A mini-symposium on acupuncture
Authors: Phillip Shapiro
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Thoracic surgery, which less than ten years ago was thought to require the placement of as many as 40 needles, is now being accomplished with only<i>one</i>needle with no less satisfactory results (<i>Chinese Med J</i>2:17, 1973). In the same issue, a report from the Shanghai First People's Hospital on acupuncture anesthesia in thyroidectomy reviews the results of using 12 different sets of acupuncture points in 700 cases. All were satisfactory, but the authors concluded that "the results with the<i>futu</i>set in the region of the dermatome over the thyroid gland were distinctly better than the other sets." These and other reports indicate that the analgesia secured by acupuncture is more than a matter of suggestibility, albeit the importance of the psychological preparation of the patient is readily accepted. In the People's Republic of China in the summer of 1972,I witnessed various applications of acupuncture
LETTER FROM NEW YORK.
Authors: None P. B. P.
Journal: JAMA (1890)

(FROM OUR OWN CORRESPONDENT.) First Examinations under the New Law—State care of the Indigent Insane—The Lamborn Prize Essays on the Mosquito and its possible extermination—Cultivation of Plants under the Electric Light —A 5-year old Child falls six stories without serious injury. The first examinations of those proposing to enter the study of medicine and law, under the direction of the Regents of the University of the State of New York, in accordance with the provisions of the new law, were held during the last week of September. In this city and Brooklyn nearly three hundred young men and a few young women were examined at the College of Physicians and Surgeons, the Medical Department of the University of the City of New York, and the Long Island College Hospital. All the students are required to pass satisfactorily in arithmetic, geography, grammar, English composition and spelling, and United States history. In
T-cell stimulator undergoes diverse testing
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Regional results of acute appendicitis care
Authors: D. E. Detmer
Journal: JAMA (1981)

In 1978, acute appendicitis care was reviewed by studying 2,375 cases from 74% of all hospitals in Wisconsin outside the greater Milwaukee area. The mortality was 0.17% and the wound complication rate was 5.3%. A normal appendix report was noted in 14% of all cases; female patients accounted for 60% of these cases, and only 44.5% of the total study population. The rupture or perforation rate was 13.4%; 62% of these problems occurred in male patients. The mean hospital stay was 5.4 days; for perforated cases, it was 10.2 days. An analysis that compared hospitals by their individual ratios of normal appendices to perforations favors the conclusion that a small but real decrease in negative appendectomy rates could be achieved without producing more ruptures or perforations. (<i>JAMA</i>1981;246:1318-1320)
Thioridazine-induced cholestasis
Authors: M. Barancik
Journal: JAMA (1967)

SINCE chlorpromazine was introduced in 1952, the list of phenothiazines causing cholestasis has grown considerably. In addition to chlorpromazine, other icterogenic phenothiazines are promazine, prochlorperazine, mepazine, and trifluoperazine.<sup>1</sup>This complication occurs in less than 1% of individuals taking phenothiazines.<sup>1,2</sup> Phenothiazine cholestasis is benign and almost always remits when the offending drug is discontinued.<sup>1-5</sup>In fact there may be remission of jaundice while the drug is being administered.<sup>4</sup>Cases are reported in which there was progression of the condition to xanthomatous biliary cirrhosis.<sup>1-3,5,6</sup>Cohen has recently stated that "an unequivocal case of jaundice due to thioridazine is not known."<sup>2</sup> In 1959, Block<sup>7</sup>reported jaundice in a 79-year-old woman who was administered modest doses of thioridazine for a nine-month period. At the end of that time, her bilirubin level was 1.2 mg/100 ml and her transaminase level was elevated. Within two weeks of stopping thioridazine,
Plakophilin-2 loss promotes TGF-β1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes
Authors: Adi D. Dubash, Chen Y. Kam, Brian A. Aguado, Dipal M. Patel, Mario Delmar, Lonnie D. Shea, Kathleen J. Green
Journal: The Journal of Experimental Medicine (2016)
Homocysteine Lowering by B Vitamins and the Secondary Prevention of Deep-Vein Thrombosis and Pulmonary Embolism. A First Randomised, Placebo-Controlled, Double-Blind Trial.
Authors: Gerard M.J. Bos, Martin Heijer den, Huub Willems, Henk Blom, Wim Gerrits, Marco Cattaneo, Sabine Eichinger, Frits Rosendaal
Journal: Blood (2004)
Occupational Dermatoses
Authors: J. G. Downing, S. J. Messina
Journal: New England Journal of Medicine (1946)

Vital Agencies Bacterial Infections Lebowich, McKillip and Conboy37 report 3 cases of cutaneous anthrax. All the patients were working in leather tanneries, where they handled imported skins. After an average incubation period of one to three days they developed anthrax of the skin, which began as a single, small, red papule on an exposed surface that enlarged rapidly, with development of a central necrotic brownish-black eschar surrounded by a pink, doughy swelling and pink vesicles. No pain was experienced but a sense of fullness and numbness at the site of infection. The constitutional symptoms were persistent headache, fatigue and weakness . . .
Web-based stress management for newly diagnosed cancer patients (STREAM): A randomized, wait-list controlled intervention study.
Authors: Viviane Hess, Astrid Grossert, Judith Alder, Sandra Scherer, Barbara Handschin, Borislava Borislavova, Sven Degen, Alexandra Faessler, Jennifer Hartung, Sarah Schibli, Celine Werndli, Jens Gaab, Thomas Berger, Thomas Zumbrunn, Corinne Urech
Journal: Journal of Clinical Oncology (2017)

LBA10002 Background: Being diagnosed with cancer causes major distress, yet the majority of newly diagnosed cancer patients (pts) lack psychological support. Internet interventions overcome many barriers for seeking support. We assess efficacy and feasibility of a web-based minimal-contact stress management intervention (STREAM) for newly diagnosed cancer pts. Methods: In a prospective, wait-list controlled trial, newly diagnosed cancer pts were randomized within 12 weeks of starting anti-cancer treatment to an immediate or delayed (control group) 8-week, web-based intervention. The intervention consisted of 8 modules with weekly written feedback by a psychologist (“minimal-contact”) based on well-established stress management manuals. The aim of this study was to evaluate efficacy in terms of improvement in QoL (FACIT-F), decrease in distress (DT), anxiety/depression (HADS), as compared to pts in the wait-list group. 120 pts were needed to show (80% power, 2-sided α of 0.05) a clinically meaningful difference of ≥ 9 in FACT score after the immediate intervention (week 8 = T2). Results: 225 pts applied online. 128 pts were randomized. Median age was 52 (22-77)y. 108 (84%) were female. The majority of pts were treated in the curative setting (117pts; 91%), with chemotherapy (74 pts; 58%), for breast cancer (91pts; 71%). Self-reported distress at baseline ( = stratification factor) was above 4 on a 10-point scale (DT) with 96 pts (75%). At T2, QoL (FACIT-F) was sign. increased (p = 0.044; ANCOVA adjusted for baseline-distress) and distress sign. lowered (p = 0.032) in the intervention group as compared to the wait-list control. Median score (lower/upper quartile) for FACIT-F at baseline/T2 was 101.0(80.8/120)/119.0(98.0/132) and 108.3(87.8/124.0) /109.5(97.2/121.0); of DT at baseline/T2 was 6(5/8)/4(3/6) and 6(5/8)/6(4/7) for the intervention and control group, respectively. Decrease in HADS was not sign. different between the groups (p = 0.273). Conclusions: With STREAM, we open the field of minimal-contact online interventions to newly diagnosed cancer pts and show that an 8-week web-based stress management program is feasible and effective in improving QoL and distress. Clinical trial information: NCT02289014.
Investigation of the Health Status of Michigan Chemical Corporation Employees
Authors: Henry A. Anderson, Mary S. Wolff, Alf Fischbein, Irving J. Selikoff
Journal: Environmental Health Perspectives (1978)

Clinical findings are reported for a group of 55 employees of the Michigan Chemical Corporation which manufactured FireMaster BP-6 from 1970 to 1974, in addition to a variety of other halogenated fire retardant chemicals. The results are compared with those from a group of male farm residents and consumers from Michigan examined at the same time. An increased prevalence of chest and skin symptoms was observed, compared with farmers. Skin symptoms were more prevalent among former PBB production personnel. Musculosketal symptoms were less prevalent among these workers than among farmers. Serum PBB concentrations are signicantly higher than among farmers. Blood chemistry results were similar for workers and farmers. However, both groups exhibited a significantly higher prevalence of elevated liver function tests (SGOT, SPGT) than a control population of nonexposed farmers. Both farmers and chemical workers showed an association of elevated CEA with serum PBB greater than 10 ppb.
From the Centers for Disease Control and Prevention. Head injuries associated with motorcycle use--Wisconsin, 1991
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Methyl Isocyanate Eight-Day Vapor Inhalation Study with Fischer 344 Rats
Authors: Darol E. Dodd, Edward H. Fowler, William M. Snellings, Irvin M. Pritts
Journal: Environmental Health Perspectives (1987)

Groups of ten male and ten female Fischer 344 rats were exposed by inhalation 3.1, 0.6, 0.15, or 0.0 (control) ppm of methyl isocyanate (MIC) vapor 6 hr per day for 8 days (two 4-day sessions separated by a 2-day rest). Evaluation of toxic effects included body weight, food consumption, organ weights, and selected hematologic, ophthalmic, neurologic, gross anatomic, and histologic examinations. There were no deaths during the study. Rats of the 3.1 ppm exposure group had decreased body weights, food consumption, and blood oxygen saturation (males only). An increase in hemoglobin concentration (males only) and in lung weights (absolute and as a percentage of body weight) were also observed in the 3.1 ppm rats. Ophthalmic or neurofunctional behavior evaluations were negative for all MIC exposure groups. Only 3.1 ppm of MIC vapor resulted in lesions in the respiratory tract, 0.6 or 0.15 ppm did not. The types of lesions observed were inflammation and squamous metaplasia in the nasal cavity, trachea, and bronchi; inflammation of the bronchioles and alveoli; and submucosal fibroplasia of the bronchioles. No significant lesions were observed in tissues other than those of the respiratory tract in all MIC exposure groups. The results of this study indicate the current 0.02 ppm threshold limit value for MIC is not too high regarding toxicity.
Hypoxia/reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice
Authors: D.K. Kaul, R.P. Hebbel
Journal: Journal of Clinical Investigation (2000)

Figure 1 Representative fluorographs of cremaster venules in β S mice (top) and their corresponding DHR fluorescence profile analysis (bottom).(a) Normoxic control.(b) After 3 hours of hypoxia and 30 minutes of reoxygenation, the peaks of DHR activity correspond to fluorescence intensity in the vascular endothelial cells.Bar = 10 µm.Hypoxia/reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice
LETTSOM AND THE REVIVAL OF OUTPATIENT MEDICINE
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the Centers for Disease Control. Outbreak of Salmonella enteritidis infection associated with consumption of raw shell eggs
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes
Authors: Youwen Fang, Song Iy Han, Clint Mitchell, Seema Gupta, Elaine Studer, Steven Grant, Phillip B. Hylemon, Paul Dent
Journal: Hepatology (2004)

Previous studies have demonstrated in hepatocytes that deoxycholic acid (DCA) promotes inactivation of protein tyrosine phosphatases (PTPases) and activation of ERBB1 and the extracellular-regulated kinase (ERK) 1/2 pathway. The present studies have determined the biochemical mechanism(s) through which these events occur. DCA and taurodeoxycholic acid (TDCA) (100 μmol/L) caused activation of ERBB1, insulin receptor, and the ERK1/2 and AKT pathways in primary rodent hepatocytes. DCA- and TDCA-induced receptor and signaling pathway activations were blocked by the reactive oxygen species (ROS) scavengers N-acetyl cysteine (NAC) and Trolox (TX), as well as by cyclosporin A (CsA) and bongkrekic acid (BKA). DCA activated the ERK1/2 pathway in HuH7 human hepatoma cells that was blocked by the incubation of cells with an ERBB1 inhibitor, NAC, TX, CsA, or BKA. DCA did not activate the ERK1/2 pathway in mitochondria-defective HuH7 Rho 0 cells. In HuH7 cells and primary hepatocytes, DCA enhanced the production of ROS, an effect that was abolished in Rho 0 cells and by prior incubation of cells with CsA or BKA. In hepatocytes and HuH7 cells, DCA inhibited PTPase activity. Incubation of hepatocytes with either CsA or BKA prevented DCA-induced inhibition of PTPase activity. Loss of mitochondrial function in Rho 0 cells also abolished the inhibitory effects of DCA on PTPase activity. In conclusion, DCA and TDCA cause ROS generation in hepatocytes that is dependent on metabolically active mitochondria. The generation of ROS is essential for PTPase inactivation, receptor tyrosine kinase activation, and enhanced signaling down the ERK1/2 and AKT pathways. (Hepatology 2004;40:961–971).
Abortion legislation
Authors: Aubrey Milunsky, Leonard H. Glantz
Journal: JAMA (1983)

<h3>In Reply.—</h3> Dr Lauinger attempted several arguments to refute our opposition to proposed federal enactments designed to outlaw abortion. First, she argued that a majority of physicians would not be affected by this legislation. If Dr Lauinger opposes only legislation that would affect a "majority" of physicians,<i>any</i>procedure performed primarily by specialists would be in danger. Later, she maintained that 1.5 million abortions are performed yearly. Of course, all these procedures were performed by many physicians. Dr Lauinger argued that most abortions are performed for "social reasons." It is not clear what she means by this. If she means that most women's decisions to abort are frivolous, we simply disagree. What few data exist indicate that women who choose to abort find the decision difficult to make and that a substantial number change their minds at least once before reaching a clinic.<sup>1</sup>What can be said with certainty
Effects of Ethylene Glycol Monomethyl Ether on Various Parameters of Testicular Function in the F344 Rat
Authors: Robert E. Chapin, James C. Lamb
Journal: Environmental Health Perspectives (1984)

These studies were designed to define the target cell for ethylene glycol monomethyl ether (EGME) action in the rodent testis, and to compare fluid production and protein secretory patterns in the testes of treated and control animals. Adult F344 rats were treated with 150 mg/kg/day, 5 day/week, and sacrificed 1, 2, 4, 7 or 10 days after the first dose. In the testes of treated animals, the most sensitive cells were the premeiotic and meiotic spermatocytes. As length of treatment continued, the younger transitional spermatocytes, and more pachytene spermatocytes, were affected. Early and late stage spermatids did not appear affected, nor was the visual appearance of spermatogonia changed by exposure to EGME. Fluid production, androgen-binding protein secretion and electrophoreograms of proteins found in the ligated rete testis were also unchanged by EGME, showing that these indices of Sertoli cell function were not affected by EGME. The histologic and biochemical data suggest that both early and late spermatocytes are targets for EGME in the testis, and that the Sertoli cells are relatively unaffected.