tbuckley/cabot-search huggingface dataset:
Graduation Poem
Authors: Laura Kolbe
Journal: Annals of Internal Medicine (2021)

Ad LibitumJune 2021Graduation PoemLaura Kolbe, MD, MPhilLaura Kolbe, MD, MPhilNewYork–Presbyterian/Weill Cornell Medical Center, New York, New YorkSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M20-2101 Audio Reading - “Graduation Poem” Audio. Virginia L. Hood, MD, a physician from the University of Vermont, reads “Graduation Poem” by Laura Kolbe, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In the towers of cancer and the towers of hearts,in the offices of the breath's small soundsand the tapped percussion of the liverand examination of red lace overlaid on skin,do not forget your home outside,the tree that shook with you the longest night of the yearthe frost patches that formed like gilding to award your tracksthe sodium street lamps on the side roads backand the soft beat of insects against screen windowswhen the summer rises around you, damp and essentiallike the first bread forming.in some black explosion of a ... Author, Article, and Disclosure InformationAffiliations: NewYork–Presbyterian/Weill Cornell Medical Center, New York, New YorkCurrent Author Address: Laura Kolbe, MD, MPhil, NewYork–Presbyterian/Weill Cornell Medical Center, Hospital Medicine, 525 East 68th Street, Box 331, New York, NY 10065; e-mail, [email protected]cornell.edu. PreviousarticleNextarticle Advertisement Audio Reading - “Graduation Poem” Audio. Virginia L. Hood, MD, a physician from the University of Vermont, reads “Graduation Poem” by Laura Kolbe, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics June 2021Volume 174, Issue 6Page: 870 ePublished: 15 June 2021 Issue Published: June 2021 Copyright & PermissionsCopyright © 2021 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Defining factors associated with high-quality surgery following radical cystectomy: Analysis of the British Association of Urological Surgeons (BAUS) cystectomy audit
Authors: W.S. Tan, J. Leow, M. Marchese, A. Sridhar, G. Hellawell, M. Mossanen, J. Teoh, S. Fowler, A. Colquhoun, J. Cresswell, J. Catto, Q-D. Trinh, J. Kelly
Journal: European Urology (2021)
Identification of aberrant glycosylation of osteopontin on urinary stone formation
Authors: G. Anan, T. Yoneyama, D. Noro, Y. Tobisawa, S. Hatakeyama, M. Yoneyama, H. Yamamoto, T. Yoneyama, Y. Hashimoto, M. Sato, C. Ohyama
Journal: European Urology (2021)
Hemolysis contributes to anemia during long-duration space flight
Authors: Guy Trudel, Nibras Shahin, Timothy Ramsay, Odette Laneuville, Hakim Louati
Journal: Nature Medicine (2022)

Anemia in astronauts has been noted since the first space missions, but the mechanisms contributing to anemia in space flight have remained unclear. Here, we show that space flight is associated with persistently increased levels of products of hemoglobin degradation, carbon monoxide in alveolar air and iron in serum, in 14 astronauts throughout their 6-month missions onboard the International Space Station. One year after landing, erythrocytic effects persisted, including increased levels of hemolysis, reticulocytosis and hemoglobin. These findings suggest that the destruction of red blood cells, termed hemolysis, is a primary effect of microgravity in space flight and support the hypothesis that the anemia associated with space flight is a hemolytic condition that should be considered in the screening and monitoring of both astronauts and space tourists.
Endoscopic intermuscular dissection for deep submucosal invasive cancer in the rectum: a new endoscopic approach
Authors: Leon M. G. Moons, Barbara A. J. Bastiaansen, Milan C. Richir, Wouter L. Hazen, Jurriaan Tuynman, Sjoerd G. Elias, Ruud W M. Schrauwen, Frank P. Vleggaar, Evelien Dekker, Philip Bos, Arantza Fariña Sarasqueta, Miangela Lacle, Roel Hompes, Paul Didden
Journal: Endoscopy (2022)

Abstract Background The risk of lymph node metastasis associated with deep submucosal invasion should be balanced against the mortality and morbidity of total mesorectal excision (TME). Dissection through the submucosa hinders radical deep resection, and full-thickness resection may influence the outcome of completion TME. Endoscopic intermuscular dissection (EID) in between the circular and longitudinal part of the muscularis propria could potentially provide an R0 resection while leaving the rectal wall intact. Methods In this prospective cohort study, the data of patients treated with EID for suspected deep submucosal invasive rectal cancer between 2018 and 2020 were analyzed. Study outcomes were the percentages of technical success, R0 resection, curative resection, and adverse events. Results 67 patients (median age 67 years; 73 % men) were included. The median lesion size was 25 mm (interquartile range 20–33 mm). The rates of overall technical success, R0 resection, and curative resection were 96 % (95 %CI 89 %–99 %), 81 % (95 %CI 70 %–89 %), and 45 % (95 %CI 33 %–57 %). Only minor adverse events occurred in eight patients (12 %). Conclusion EID for deep invasive T1 rectal cancer appears to be feasible and safe, and the high R0 resection rate creates the potential of rectal preserving therapy in 45 % of patients.
Transapical mitral valve implantation for treatment of symptomatic mitral valve disease: a real‐world multicentre experience
Authors: Mirjam G. Wild, Felix Kreidel, Michaela M. Hell, Fabien Praz, Markus Mach, Matti Adam, David Reineke, Hendrik Ruge, Sebastian Ludwig, Lenard Conradi, Tanja K. Rudolph, Sabine Bleiziffer, Jörg Kellermair, Andreas Zierer, Georg Nickenig, Marcel Weber, Anna Sonia Petronio, Cristina Giannini, Gry Dahle, Kjell A. Rein, Augustin Coisne, André Vincentelli, Christophe Dubois, Alison Duncan, Cesare Quarto, Axel Unbehaun, Ignacio Amat‐Santos, Javier Cobiella, Nicolas Dumonteil, Rodrigo Estevez‐Loureiro, Andrea Fumero, Tobias Geisler, Philipp Lurz, Antonio Mangieri, Vanessa Monivas, Thilo Noack, Luis Nombela Franco, Miguel A. Pinon, Lukas Stolz, Didier Tchétché, Thomas Walter, Bernhard Unsöld, Stephan Baldus, Martin Andreas, Jörg Hausleiter, Ralph S. von Bardeleben
Journal: European Journal of Heart Failure (2022)
Persistence of severe liver fibrosis despite substantial weight loss with bariatric surgery
Authors: Raluca Pais, Judith Aron‐Wisnewsky, Pierre Bedossa, Maharajah Ponnaiah, Jean‐Michel Oppert, Jean‐Michel Siksik, Laurent Genser, Frederic Charlotte, Dominique Thabut, Karine Clement, Vlad Ratziu
Journal: Hepatology (2022)

It remains unclear to what extent and which components of advanced liver disease improve after bariatric surgery. We herein describe the histological outcome in patients with advanced NASH and its relationship with weight loss and metabolic improvement.One hundred ninety-six patients with advanced NASH underwent bariatric surgery, 66 of whom agreed to a follow-up liver biopsy at 6 ± 3 years (36 with advanced fibrosis [AF] and 30 with high activity [HA] grade without AF). Liver biopsies LBs were centrally read and histological response was defined as the disappearance of AF or HA. Bariatric surgery induced major histological improvement: 29% of patients had normal histology at follow-up biopsy; 74% had NASH resolution without fibrosis progression; and 70% had ≥1 stage fibrosis regression. However, AF persisted in 47% of patients despite NASH resolution and some degree of fibrosis reversal, only evidenced by the EPoS seven-tier staging classification. These patients had lower weight loss and reduced hypertension or diabetes remission rates. Older age and sleeve gastrectomy were the only independent predictors for persistent AF after adjustment for duration of follow-up. All HA patients had major histological improvement: 50% normal histology, 80% NASH resolution, and 86% a ≥1 grade steatosis reduction. Patients with normal liver at follow-up had the largest weight loss and metabolic improvement. Independent predictors of normal liver were amount of weight loss, high histological activity, and the absence of AF before surgery.Although bariatric surgery successfully reverses active steatohepatitis, AF can persist for many years and is associated with lesser weight loss and metabolic improvement. Weight loss alone may not be sufficient to reverse AF.
Advances in Non-Invasive Blood Pressure Measurement Techniques
Authors: Tuukka Panula, Jukka-Pekka Sirkia, David Wong, Matti Kaisti
Journal: IEEE Reviews in Biomedical Engineering (2022)

Hypertension, or elevated blood pressure (BP), is a marker for many cardiovascular diseases and can lead to life threatening conditions such as heart failure, coronary artery disease and stroke. Several techniques have recently been proposed and investigated for non-invasive BP monitoring. The increasing desire for telemonitoring solutions that allow patients to manage their own conditions from home has accelerated the development of new BP monitoring techniques. In this review, we present the recent progress in non-invasive blood pressure monitoring solutions emphasizing clinical validation and trade-offs between available techniques. We introduce the current BP measurement techniques with their underlying operating principles. New promising proof-of-concept studies are presented and recent modeling and machine learning approaches for improved BP estimation are summarized. This aids discussions on how new BP monitors should evaluated in order to bring forth new home monitoring solutions in wearable form factor. Finally, we discuss on unresolved challenges in making convenient, reliable and validated BP monitoring solutions.
Eliminating Explicit and Implicit Biases in Health Care: Evidence and Research Needs
Authors: Monica B. Vela, Amarachi I. Erondu, Nichole A. Smith, Monica E. Peek, James N. Woodruff, Marshall H. Chin
Journal: Annual Review of Public Health (2022)

Health care providers hold negative explicit and implicit biases against marginalized groups of people such as racial and ethnic minoritized populations. These biases permeate the health care system and affect patients via patient-clinician communication, clinical decision making, and institutionalized practices. Addressing bias remains a fundamental professional responsibility of those accountable for the health and wellness of our populations. Current interventions include instruction on the existence and harmful role of bias in perpetuating health disparities, as well as skills training for the management of bias. These interventions can raise awareness of provider bias and engage health care providers in establishing egalitarian goals for care delivery, but these changes are not sustained, and the interventions have not demonstrated change in behavior in the clinical or learning environment. Unfortunately, the efficacy of these interventions may be hampered by health care providers' work and learning environments, which are rife with discriminatory practices that sustain the very biases US health care professions are seeking to diminish. We offer a conceptual model demonstrating that provider-level implicit bias interventions should be accompanied by interventions that systemically change structures inside and outside the health care system if the country is to succeed in influencing biases and reducing health inequities.
Why mandatory vaccination for healthcare workers should not be scrapped
Authors: Daniel Sokol
Journal: BMJ (2022)

At the time of writing (24 January 2022), unvaccinated NHS workers in England have only until 3 February 2022 to get their first dose of the covid-19 vaccine.Those who do not risk dismissal.The i newspaper reported last Friday that the government was now "actively" considering a temporary suspension of the policy. 1 A few days before, a leaked document written by officials at the Department of Health and Social Care raised doubts on the wisdom of mandatory covid vaccines for NHS workers. 2 The argument is that two vaccine doses provide only up to 32% effectiveness against omicron infection, then gradually wane until no longer effective without a booster.Further, omicron, although far more transmissible, is less likely to lead to severe illness and hospital admission than the delta variant.
Errors in Figure 1
Journal: JAMA Network Open (2022)

Outcomes of Transcatheter Arterial Chemoembolization Combined With Radiofrequency Ablation as an Initial Treatment for Early-Stage Hepatocellular Carcinoma," 1 published September 27, 2021, there were errors in the number of patients included at several stages of the flow diagram in Figure 1.This article has been corrected. 1
Molecular Mechanisms of Multimeric Assembly of IgM and IgA
Authors: Marissa L. Matsumoto
Journal: Annual Review of Immunology (2022)

As central effectors of the adaptive immune response, immunoglobulins, or antibodies, provide essential protection from pathogens through their ability to recognize foreign antigens, aid in neutralization, and facilitate elimination from the host. Mammalian immunoglobulins can be classified into five isotypes-IgA, IgD, IgE, IgG, and IgM-each with distinct roles in mediating various aspects of the immune response. Of these isotypes, IgA and IgM are the only ones capable of multimerization, arming them with unique biological functions. Increased valency of polymeric IgA and IgM provides high avidity for binding low-affinity antigens, and their ability to be transported across the mucosal epithelium into secretions by the polymeric immunoglobulin receptor allows them to play critical roles in mucosal immunity. Here we discuss the molecular assembly, structure, and function of these multimeric antibodies.
Assessing predictors of chronic kidney disease progression in patients receiving minimally-invasive partial nephrectomy: Results of a multi-institutional collaborative series
Authors: U. Anceschi, R.S. Flammia, A. Brassetti, G. Tuderti, M.C. Ferriero, A. Minervini, A. Mari, A.A. Grasso, M. Carini, U. Capitanio, A. Larcher, F. Montorsi, R. Autorino, A. Veccia, C. Fiori, D. Amparore, F. Porpiglia, D. Eun, J. Lee, I. Deerwesh, C. Sundaram, J. Steward, M. Gallucci, G. Simone
Journal: European Urology (2021)
How to Go Forward After Your Second Child Dies
Authors: Amy N. Ship
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Osteoporotic bone recovery by a bamboo-structured bioceramic with controlled release of hydroxyapatite nanoparticles
Authors: Rui Zhao, Tieliang Shang, Bo Yuan, Xiangdong Zhu, Xingdong Zhang, Xiao Yang
Journal: Bioactive Materials (2022)

While most bone defects can be repaired spontaneously, the healing process can be complicated due to insufficient bone regeneration when osteoporosis occurs. Synthetic materials that intrinsically stimulate bone formation without inclusion of exogenous cells or growth factors represent a highly desirable alternative to current grafting strategies for the management of osteoporotic defects. Herein, we developed a series of hydroxyapatite bioceramics composed of a microwhiskered scaffold (wHA) reinforced with multiple layers of releasable hydroxyapatite nanoparticles (nHA). These novel bioceramics (nwHA) are tunable to optimize the loading amount of nHA for osteoporotic bone formation. The utility of nwHA bioceramics for the proliferation or differentiation of osteoporotic osteoblasts in vitro is demonstrated. A much more compelling response is seen when bioceramics are implanted in critical-sized femur defects in osteoporotic rats, as nwHA bioceramics promote significantly higher bone regeneration and delay adjacent bone loss. Moreover, the nwHA bioceramics loaded with a moderate amount of nHA can induce new bone formation with a higher degree of ossification and homogenization. Two types of osteogenesis inside the nwHA bioceramic pores were discovered for the first time, depending on the direction of growth of the new bone. The current study recommends that these tailored hybrid micro/nanostructured bioceramics represent promising candidates for osteoporotic bone repair.
Technical standards for respiratory oscillometry and bronchodilator response cut-offs
Authors: Cindy Thamrin, Paul D. Robinson, Claude S. Farah, Gregory G. King
Journal: European Respiratory Journal (2022)

<b>Bronchodilator response cut-offs from oscillometry are robust across devices, and should be separated for adults (<i>R</i>rs<sub>5</sub> −32% and <i>X</i>rs<sub>5</sub> 44%) and children (<i>R</i>rs<sub>5</sub> −40% and <i>X</i>rs<sub>5</sub> 50%). Absolute and Z-score cut-offs should also be considered.</b>https://bit.ly/3FcjDfK
Editorial Board
Authors: James Field, Samuel Soskin, Beverly Hills, Garfield Duncan, Salman Azhar, Palo Alto, Hisham Barakat, George Bray, Jorge Calles-Escandon, José Caro, M Charles, San Francisco, George Chrousos, Bernard Bethesda, St Davis, Leslie Louis, Frederick Degroot, Mario Derubertis, Atlanta Digirolamo, William Ga, Louis Duckworth, John Elsas, Kenneth Fain, San Feingold, Andrew Francisco, New Frantz, Gregory York, Saul Freund, Henry Cleveland, New Ginsberg, Charles York, Jane Glueck, Abbas Cleveland, Fredric Kitabchi, Stanford Kraemer, Robert Kraemer, Nelly Mauras, James May, Donald Mcnamara, Glenn Mortimore, Maria New, New York, Michael Pagliassotti, Ft Collins, William Pandak, Alan Richmond, Los Robinson, Peter Angeles, Richard Stacpoole, Marc Durham, John Tucson
Journal: Metabolism (2007)
Abdominopelvic Actinomycosis
Authors: Noriko Arakaki, Yusuke Oshiro
Journal: New England Journal of Medicine (2021)

A 54-year-old-woman presented with fevers, weight loss, and abdominal pain. Imaging showed an intrauterine device surrounded by multiple abdominopelvic abscesses. Actinomyces israelii was grown on culture.
Errors in Figure 3
Journal: JAMA Psychiatry (2020)

Nadine Parker, MSc; Yash Patel, BSc; Andrea P. Jackowski, MD, PhD; Pedro M. Pan, MD, PhD; Giovanni Abrahao Salum, MD, PhD; Zdenka Pausova, MD; Tomáš Paus, MD, PhD; Saguenay Youth Study and the IMAGEN Consortium
Screening for Atrial Fibrillation—More Data Still Needed
Authors: Philip Greenland
Journal: JAMA (2022)

US Preventive Services Task Force; Karina W. Davidson, PhD, MASc; Michael J. Barry, MD; Carol M. Mangione, MD, MSPH; Michael Cabana, MD, MA, MPH; Aaron B. Caughey, MD, PhD; Esa M. Davis, MD, MPH; Katrina E. Donahue, MD, MPH; Chyke A. Doubeni, MD, MPH; John W. Epling Jr, MD, MSEd; Martha Kubik, PhD, RN; Li Li, MD, PhD, MPH; Gbenga Ogedegbe, MD, MPH; Lori Pbert, PhD; Michael Silverstein, MD, MPH; James Stevermer, MD, MSPH; Chien-Wen Tseng, MD, MPH, MSEE; John B. Wong, MD
Correction: Downregulation of MicroRNA-644a Promotes Esophageal Squamous Cell Carcinoma Aggressiveness and Stem Cell–like Phenotype via Dysregulation of PITX2
Authors: Jia-Xing Zhang, Zhen-Hua Chen, Yi Xu, Jie-Wei Chen, Hui-Wen Weng, Miao Yun, Zou-San Zheng, Cui Chen, Bing-Li Wu, En-Min Li, Jian-Hua Fu, Sheng Ye, Dan Xie
Journal: Clinical Cancer Research (2021)

In the original version of this article (1), the authors found five images that were published in error: Fig. 2B, colony formation assay of KYSE-140/miR-644a; Fig. 2C, migration assay of KYSE-140/control (0h); Fig. 2D, invasion assay of KYSE-140/miR-644a; Fig. 4C, “Scramble” proportion of side population cells (top image); and Fig. 5C, alpha-tubulin Western blots (right image). The errors have been corrected in the latest online HTML and PDF versions of the article. The authors regret the errors.
Less mortality and less Major Adverse Cardiovascular Events (MACE) under long-term Testosterone Therapy (TTh): 15-year data from a prospective controlled registry study
Authors: A. Al-Qudimat, R. Al-Zuobi, O.M. Aboumarzouk, F. Saad, K. Haider, A. Alansari, A. Yassin, S. Alkadhi
Journal: European Urology (2021)
1054P FDG-PET to predict long-term outcome from anti-PD1 (PD1) therapy in metastatic melanoma
Authors: F. Dimitriou, S. Lo, A.C. Tan, L. Emmett, R. Kapoor, M. Carlino, G.V. Long, A.M. Menzies
Journal: Annals of Oncology (2021)
sPLINK: a hybrid federated tool as a robust alternative to meta-analysis in genome-wide association studies
Authors: Reza Nasirigerdeh, Reihaneh Torkzadehmahani, Julian Matschinske, Tobias Frisch, Markus List, Julian Späth, Stefan Weiss, Uwe Völker, Esa Pitkänen, Dominik Heider, Nina Kerstin Wenke, Georgios Kaissis, Daniel Rueckert, Tim Kacprowski, Jan Baumbach
Journal: Genome biology (2022)

Abstract Meta-analysis has been established as an effective approach to combining summary statistics of several genome-wide association studies (GWAS). However, the accuracy of meta-analysis can be attenuated in the presence of cross-study heterogeneity. We present sPLINK , a hybrid federated and user-friendly tool, which performs privacy-aware GWAS on distributed datasets while preserving the accuracy of the results. sPLINK is robust against heterogeneous distributions of data across cohorts while meta-analysis considerably loses accuracy in such scenarios. sPLINK achieves practical runtime and acceptable network usage for chi-square and linear/logistic regression tests. sPLINK is available at https://exbio.wzw.tum.de/splink .
Pathogenesis of Triple-Negative Breast Cancer
Authors: Fatemeh Derakhshan, Jorge S. Reis-Filho
Journal: Annual Review of Pathology Mechanisms of Disease (2022)

Triple-negative breast cancer (TNBC) encompasses a heterogeneous group of fundamentally different diseases with different histologic, genomic, and immunologic profiles, which are aggregated under this term because of their lack of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression. Massively parallel sequencing and other omics technologies have demonstrated the level of heterogeneity in TNBCs and shed light into the pathogenesis of this therapeutically challenging entity in breast cancer. In this review, we discuss the histologic and molecular classifications of TNBC, the genomic alterations these different tumor types harbor, and the potential impact of these alterations on the pathogenesis of these tumors. We also explore the role of the tumor microenvironment in the biology of TNBCs and its potential impact on therapeutic response. Dissecting the biology and understanding the therapeutic dependencies of each TNBC subtype will be essential to delivering on the promise of precision medicine for patients with triple-negative disease.