tbuckley/cabot-search huggingface dataset:
Anticipation and Treatment of Post Partum Haemorrhage
Authors: W. B. Mushet
Journal: BMJ (1873)

6oi difficult to transfer the pressure to the aorta, a proceeding which I have often seen of great service; then cold may be added as an excellent assistant to pressure; in certain cases, opium is a valuable remedy.The precise position which a solution of the perchloride of iron will occupy in the future I cannot tell; it has not, in my hands, appeared to be so innocent an agent as, from what has been written about it, I had sup- posed; but, as my experience has been limited, I give no decided opinion.
Polysaccharide-based nanomedicines for cancer immunotherapy: A review
Authors: Yujun Zeng, Yufan Xiang, Ruilong Sheng, Helena Tomás, João Rodrigues, Zhongwei Gu, Hu Zhang, Qiyong Gong, Kui Luo
Journal: Bioactive Materials (2021)

Cancer immunotherapy is an effective antitumor approach through activating immune systems to eradicate tumors by immunotherapeutics. However, direct administration of "naked" immunotherapeutic agents (such as nucleic acids, cytokines, adjuvants or antigens without delivery vehicles) often results in: (1) an unsatisfactory efficacy due to suboptimal pharmacokinetics; (2) strong toxic and side effects due to low targeting (or off-target) efficiency. To overcome these shortcomings, a series of polysaccharide-based nanoparticles have been developed to carry immunotherapeutics to enhance antitumor immune responses with reduced toxicity and side effects. Polysaccharides are a family of natural polymers that hold unique physicochemical and biological properties, as they could interact with immune system to stimulate an enhanced immune response. Their structures offer versatility in synthesizing multifunctional nanocomposites, which could be chemically modified to achieve high stability and bioavailability for delivering therapeutics into tumor tissues. This review aims to highlight recent advances in polysaccharide-based nanomedicines for cancer immunotherapy and propose new perspectives on the use of polysaccharide-based immunotherapeutics.
182P Impact of SARS CoV 2 outbreak in the molecular diagnosis of advanced NSCLC: A retrospective comparative cohort study
Authors: E. Marin, C. Teixido, A. Arcocha, S. Castillo, R. Reyes, N. Viñolas, L. Mezquita, S. Muñoz, D. Martinez, P. Jares, N. Reguart
Journal: Journal of Thoracic Oncology (2021)
Overdrive stimulation of functional reentrant circuits causing ventricular tachycardia in the infarcted canine heart. Resetting and entrainment.
Authors: BWaldecker, JCoromilas, A ESaltman, S MDillon, A LWit
Journal: Circulation (1993)

BACKGROUNDClinical electrophysiology studies have used, for the most part, models of anatomic reentrant circuits to explain entrainment of ventricular tachycardia. Our studies use activation maps to directly determine mechanisms of entrainment of functional circuits that cause tachycardia.METHODS AND RESULTSElectrograms were recorded from 192 sites on reentrant circuits in the epicardial border zone of canine myocardial infarcts during sustained ventricular tachycardia. Overdrive stimulation from different sites and at different cycle lengths was investigated. The reentrant circuits were shown to be functional, yet stimulated impulses could enter and repetitively reset the circuits (entrainment), demonstrating the presence of an excitable gap. Entrainment could occur from different stimulation sites with the stimulated impulses from each site activating the circuit with a different pattern. Entrainment, however, did not occur when the stimulated wave fronts obliterated the lines of functional block in the...
Gastric Polyps: Clinical, Endoscopic and Pathological Features
Authors: S Bradai, A Khsiba, M Medhioub, M Mahmoudi, A Ben mohamed, L Hamzaoui, MM Azzouz
Journal: Endoscopy (2021)

Aims Gastric polyps are fairly frequent but they are asymptomatic lesions discovered incidentally on endoscopic examinations performed for various reasons. The objective of this study is to describe their anatomoclinical and endoscopic features.
Endoscopic Resection In Case Of Tumor Of Distal Common Bile Duct
Authors: I Nedoluzhko, E Grishina, E Khon, K Shishin, N Kurushkina, L Shumkina
Journal: Endoscopy (2021)

Patient 56 y.o. In anamnesis single attack of acute cholangitis. According to the examination, an intra-ampullar tumor without signs of invasion of the muscular wall of the duodenum was found.
Covid-19: Pfizer reports 100% vaccine efficacy in children aged 12 to 15
Authors: Elisabeth Mahase
Journal: BMJ (2021)

Pfizer reports 100% vaccine efficacy in children aged 12 to 15 Elisabeth MahaseThe Pfizer-BioNTech covid-19 vaccine has shown 100% efficacy against SARS-CoV-2 in 12 to 15 year olds in the preliminary results of a phase III trial.1
Porcine xenograft valves. Long-term (60-89-month) follow-up.
Authors: J BLakier, FKhaja, D JMagilligan, SGoldstein
Journal: Circulation (1980)

An analysis of 211 patients who had porcine xenograft valve replacements at Henry Ford Hospital between October 1971 and March 1974, was accomplished, with 100% follow-up. The follow-up period extended from 60-89 months after implantation. One hundred sixty-seven patients with 192 valves survived the perioperative period and were subjected to life table analysis. Hemodynamically significant porcine xenograft degeneration that required reoperation occurred in 18 patients, two of whom had infective endocarditis. Only four valves failed within 48 months of surgery. Ten of 42 (23.8%) patients with isolated aortic valve replacement and eight of 102 patients (7.8%) patients with isolated mitral valve replacement required reoperation (p < 0.01). In patients under 25 years of age, six of nine surviving patients had repeat operations. Our data indicate that porcine xenograft degeneration is related to the duration of implantation and the age of the patient at the time implantation was performed. In addition, porci...
Tissue factor is expressed on monocytes during simulated extracorporeal circulation.
Authors: JKappelmayer, ABernabei, L HEdmunds, T SEdgington, R WColman
Journal: Circulation Research (1993)

Certain forms of extracorporeal circulation exemplified by cardiopulmonary bypass require continuous high-dose anticoagulation to prevent thromboembolic complications. We hypothesized that monocytes may be stimulated to express tissue factor (TF) during prolonged simulated extracorporeal circulation. TF was identified both by flow cytometry by using three TF-specific monoclonal antibodies and functional assay of procoagulant activity (PCA). TF significantly increased between 2 and 6 hours of simulated extracorporeal circulation by both analyses. Relative fluorescence on monocytes increased from a control value of 100 to 313 +/- 79 on cells from the simulated extracorporeal circuit (p < 0.05). PCA increased from 21 +/- 8 to 775 +/- 326 pg TF/10(6) monocytes (p < 0.05) and was blocked 99.6% by preincubation of cells with a mixture of monoclonal antibodies to TF. By 6 hours, the number of leukocytes in the circuit was decreased by 43%. The cells were recovered from the oxygenator membrane by washing with EDT...
Hyperemia of the aortic wall in atherosclerotic monkeys.
Authors: D DHeistad, M LArmstrong, M LMarcus
Journal: Circulation Research (1981)

The aortic wall is nourished by diffusion from the aortic lumen and from vasa vasorum in the adventitia and outer layers of media. Intimal proliferation in atherosclerosis might be expected to reduce the effectiveness of diffusion from the lumen and increase dependence on nourishment by vasa. This study was performed to determine whether there is increased perfusion of the aortic wall by vasa vasorum in atherosclerosis. We used microspheres to measure flow through vasa in normal and atherosclerotic cynomolgus monkeys. Blood flow to inner layers of the thoracic and abdominal aorta was less than 1 ml/min X 100 g in normal monkeys, and there was a minimal increase in atherosclerotic monkeys. Flow to the outer layers of the thoracic and abdominal aorta was 1.3 +/- 0.9 and 2.2 +/- 0.8 ml/min per 100 g in normal monkeys. Flow to outer layers of the thoracic and abdominal aorta was increased in atherosclerotic monkeys to 17 +/- 8.9 and 31 +/- 12 ml/min per 100 g (P less than 0.05 vs. normal). Thus there is incre...
Language Development of Young Children Is Not Linked to Phthalate Exposure—Reply
Authors: Carl-Gustaf Bornehag, Abraham Reichenber, Shanna H. Swan
Journal: JAMA Pediatrics (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
The application of radionuclide infarct scintigraphy to diagnose perioperative myocardial infarction following revascularization.
Authors: S CKlausner, E HBotvinick, DShames, D JUllyot, N HFishman, B BRoe, P AEbert, KChatterjee, W WParmley
Journal: Circulation (1977)

To evaluate the application of radionuclide infarct scintigraphy to diagnose myocardial infarction after revascularization, we obtained postoperative technetium 99m pyrophosphate myocardial scintigrams, serial electrocardiograms and CPK-MB isoenzymes in ten control and 51 revascularized patients. All control patients had negative electrocardiograms and scintigrams, but eight had positive isoenzymes. Eight revascularized patients had positive electrocardiograms, images and enzymes and two had positive scintigrams and enzymes with negative electrocardiograms. Thirty-four patients with negative electorcardiograms and scintigrams had positive isoenzymes; in only seven patients were all tests negative. Our data suggest radionuclide infarct scintigraphy is a useful adjunct to the electrocardiogram in diagnosing perioperative infarction. The frequent presence of CPK-MB in postoperative patients without other evidence of infarction suggests that further studies are required to identify all factors responsible for...
Sites of prostaglandin synthesis in the bovine heart and isolated bovine coronary microvessels.
Authors: M EGerritsen, M PPrintz
Journal: Circulation Research (1981)

Metabolically active coronary microvessels (generally less than 100 micrometers in diameter) were isolated from bovine hearts. These preparations were virtually free of contaminating myocytes and consisted of a mixture of arterioles, venules, capillaries, and collagen fibers. The prostaglandin biosynthetic capacity of isolated coronary microvessels was assessed by quantitating conversion of 14C-arachidonic acid and 14C-prostaglandin endoperoxide (PGH2) to prostaglandins. Coronary microvessels were found to exhibit low cyclooxygenase activity, i.e., minimal conversion (less than 1%) of arachidonic acid (AA) to prostaglandins when compared with either the coronary artery (3.6% conversion of AA) or coronary vein (3.3%). Isolated myofibril fractions demonstrated virtually no cyclooxygenase activity (less than 0.1%). Two enzymatic endoperoxide metabolizing activities were evident in the microvessels, prostacyclin synthetase and PGE isomerase. When compared on a microsomal protein basis, the coronary artery exh...
Man Vs Machine – Automated Colonoscopy Withdrawal Time Calculation VS Endoscopist Self-Report
Authors: M Bhandari, L Hlaing, H Phan, F Borca, K Cowin, R Beegan, J Geeson, J Batchelor, R Nouraei, D Cable, I Rahman, M Stammers
Journal: Endoscopy (2021)

Aims Colonoscopy electronic patient record (EPR) reporting systems are generally reliant on endoscopist self-report to accurately determine procedure withdrawal time – a key metric of high-quality colonoscopy. As the accuracy of self-report vs image-linked timestamping is presently unknown our aim was to investigate this.
Regional myocardial blood flow and glucose utilization in symptomatic patients with hypertrophic cardiomyopathy.
Authors: C ANienaber, S SGambhir, F VMody, ORatib, S CHuang, M EPhelps, H RSchelbert
Journal: Circulation (1993)

BACKGROUNDPrevious studies suggested the presence of myocardial ischemia in symptomatic patients with hypertrophic cardiomyopathy. Positron emission tomography, a technique that can identify metabolic consequences of ischemia in coronary artery disease, permits the noninvasive measurements of regional myocardial blood flow and glucose metabolism. This new quantitative imaging approach should therefore be suitable for detecting a possible enhancement of glucose utilization in myocardium of patients with hypertrophic cardiomyopathy and thus may help to elucidate the pathomechanism of ischemia in this disease.METHODS AND RESULTSIn 13 symptomatic patients with hypertrophic cardiomyopathy, myocardial blood flow and glucose utilization were measured with intravenous N-13-ammonia and F-18 deoxyglucose at rest and, in four patients, again during supine bicycle exercise. At rest, blood flow was significantly lower in hypertrophied than in normal myocardium (0.78 +/- 0.19 versus 0.99 +/- 0.13 mL.min-1.g-1, p < 0.02...
What’s hot that the other lot got
Authors: Kavina Shah
Journal: Thorax (2018)

Cyclophosphamide is the accepted standard of care for individuals with progressive CTD-ILD. Its efficacy and adverse effects in CTD-ILD has recently been published in a Cochrane review (Barnes et al. Cochrane Database Syst Rev 2018;1:CD010908). Four trials with 495 participants (mostly with systemic sclerosis) were included. When compared with placebo, there was a statistically significant but clinically small improvement in post cyclophosphamide FVC (% mean difference (MD) 2.83, 95% CI 0.80 to 4.87; p=0.006) but no difference in post cyclophosphamide DLCO (% MD −1.68, 95% CI −4.37 to 1.02; p=0.22; two trials, 182 participants). When comparing cyclophosphamide with mycophenolate mofetil (MMF) at 1 year (two trials, 149 participants), there was no significant difference in lung function (p=0.61) or diffusion capacity (p=0.76). Improvement in lung function was more pronounced in patients with worse baseline spirometry and fibrosis scores. As may be expected, there was a greater risk of side effects with cyclophosphamide when compared with both placebo and …
Chlamydia pneumoniae-specific circulating immune complexes in patients with chronic coronary heart disease.
Authors: ELinnanmäki, MLeinonen, KMattila, M SNieminen, VValtonen, PSaikku
Journal: Circulation (1993)

BACKGROUNDAn association of chronic Chlamydia pneumoniae infection to coronary heart disease has been suggested recently. In a recent study, we demonstrated circulating immune complexes containing chlamydial genus-specific lipopolysaccharide in patients with coronary heart disease. The objective of the present study was to investigate whether C. pneumoniae species-specific immune complexes are present in chronic coronary heart disease.METHODS AND RESULTSThe presence of Chlamydia-specific circulating immune complexes was studied in 46 patients with chronic coronary heart disease and in control subjects. Chlamydial lipopolysaccharide-containing immune complexes were detected with the antigen-specific capture method, and they were present in 41% of patients and 15% of control subjects (p < 0.01). The presence of C. pneumoniae antibodies in circulating immune complexes was studied by testing the specificity of antibodies derived from isolated and dissociated immune complexes by microimmunofluorescence testing...
Analysis of systolic bulging. Mechanical characteristics of acutely ischemic myocardium in the conscious dog.
Authors: MAkaishi, W SWeintraub, R MSchneider, L WKlein, J BAgarwal, R HHelfant
Journal: Circulation Research (1986)

To determine the mechanical factors affecting regional segmental motion after acute coronary occlusion, we studied seven conscious dogs, instrumented with sonomicrometers. Loading conditions were changed by the withdrawal of 500 ml of blood and the transfusion of 800 ml of blood. To express segmental motion, percent systolic shortening, percent systolic elongation, and early diastolic shortening were calculated. Blood withdrawal decreased left ventricular preload, increased percent systolic elongation (from 6.9 +/- 3.1% to 9.9 +/- 3.5%) and early diastolic shortening (12.9 +/- 5.3% to 16.6 +/- 5.3%), and decreased percent systolic shortening. Blood transfusion increased left ventricular preload, decreased percent systolic elongation (to 5.2 +/- 1.8%) and early diastolic shortening (8.8 +/- 2.9%), and increased percent systolic shortening. Manipulation of loading did not change regional myocardial blood flow. In acutely ischemic myocardium, the tension-length loop showed an exponential upstroke during isov...
Resolution of Pyloric Stenosis Using Lumen-Apposing Metal Stent Through the Pylorus
Authors: C Chálim Rebelo, N Nunes, M Flor de Lima, DB Moura, MP Santos, V Costa Santos, AC Rego, JR Pereira, N Paz, MA Duarte
Journal: Endoscopy (2021)

78-years-old woman presents with vomiting. Endoscopy showed pyloric stenosis, refractory to balloon dilation. MRI disclosed a mass of the pancreatic head. Was decided for endoscopic treatment.
Natriuretic peptide system in human heart failure.
Authors: C MWei, D MHeublein, M APerrella, ALerman, R JRodeheffer, C GMcGregor, W DEdwards, H VSchaff, J CBurnett
Journal: Circulation (1993)

BACKGROUNDAtrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP) are a family of structurally related peptides that participate in the integrated control of renal and cardiovascular function. Previous studies suggest a functional role for these hormonal peptides in cardiorenal regulation in congestive heart failure (CHF).METHODS AND RESULTSThe present studies were performed in normal subjects (n = 6) and in patients with mild (New York Heart Association [NYHA] class I to II, n = 20) and severe (NYHA class III to IV, n = 20) CHF by use of radioimmunoassay and immunohistochemical staining (IHCS). Plasma ANP was significantly increased in both mild and severe CHF compared with normal subjects. In contrast, plasma BNP was only moderately increased in the severe CHF group, and plasma CNP concentration was unchanged in CHF compared with normal subjects. Atrial tissue concentrations of the natriuretic peptides did not parallel circulating concentrations. ANP predo...
Calcium and Vitamin D Supplements and Fractures in Community-Dwelling Adults
Authors: Simiao Tian, Dewei Zhao
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hemodynamic and autonomic nervous system responses to mixed meal ingestion in healthy young and old subjects and dysautonomic patients with postprandial hypotension.
Authors: L ALipsitz, S MRyan, J AParker, RFreeman, J YWei, A LGoldberger
Journal: Circulation (1993)

BACKGROUNDAlthough postprandial hypotension is a common cause of falls and syncope in elderly persons and in patients with autonomic insufficiency, the pathophysiology of this disorder remains unknown.METHODS AND RESULTSWe examined the hemodynamic, splanchnic blood pool, plasma norepinephrine (NE), and heart rate (HR) power spectra responses to a standardized 400-kcal mixed meal in 11 healthy young (age, 26 +/- 5 years) and nine healthy elderly (age, 80 +/- 5 years) subjects and 10 dysautonomic patients with symptomatic postprandial hypotension (age, 65 +/- 16 years). Cardiac and splanchnic blood pools were determined noninvasively by radionuclide scans, and forearm vascular resistance was determined using venous occlusion plethysmography. In healthy young and old subjects, splanchnic blood volume increased, but supine blood pressure remained unchanged after the meal. In both groups, HR increased and systemic vascular resistance remained stable. Forearm vascular resistance and cardiac index increased afte...
Endoscopic Surveillance of Piecemeal Endoscopic Mucosal Resection of Colorectal Lesions: Should we Stratify?
Authors: M João, F Taveira, M Areia, S Alves, D Brito, S Saraiva, L Elvas, AT Cadime
Journal: Endoscopy (2021)

Aims Recurrence rates up to 24 % after piecemeal endoscopic resection (pEMRc) of colorectal lesions >20 mm provides the rationale to recommend a standardized surveillance program. We intended to assess endoscopic recurrence rate and its predictors over 5 years of follow-up and to determine safety of a personalized surveillance strategy based on risk factors.
Short-term myocardial uptake of lidocaine and mexiletine in patients with ischemic heart disease.
Authors: J DHorowitz, M KDynon, EWoodward, S TSia, P SMacdonald, D JMorgan, A JGoble, W JLouis
Journal: Circulation (1986)

Determination of short-term myocardial drug uptake and subsequent redistribution was performed in 27 patients with ischemic heart disease for the antiarrhythmic agents lidocaine and mexiletine, using frequent simultaneous measurements of drug concentration in aortic and coronary sinus blood, combined with measurement of coronary sinus blood flow after intravenous bolus injection of the drug. Maximal myocardial drug content per unit resting coronary sinus blood flow (MDC:F) was significantly greater in patients in whom coronary sinus pacing at 100 beat/min was performed during the initial period of drug uptake. Maximal myocardial drug content occurred after 2.4 +/- 0.2 (SEM) for lidocaine and after 5.5 +/- 0.6 min for mexiletine (p less than .001), and pacing did not affect time to maximum myocardial drug content. In nonpaced, but not paced, patients maximal MDC:F was greater in the lidocaine group than that in the mexiletine group. The subsequent efflux of lidocaine from the myocardium was more rapid that...