tbuckley/cabot-search huggingface dataset:
Renovascular status after renal surgery for hypertension
Authors: P. P. de Mendonca
Journal: JAMA (1967)

Twenty-nine patients who are asymptomatic after surgical treatment of renovascular hypertension have been followed with renal function studies for periods of three months to six years. Fifteen of the patients are normotensive, five after vascular repair and ten after nephrectomy. Six of the patients remained hypertensive, while ten others showed labile hypertension. No consistent correlation of renal function, changes in ocular fundi, or renal biopsy with blood pressure and symptomatic response is apparent in this series. The lack of improvement of renal function in some, with remission of blood pressure and symptoms is of interest. Four patients, who were normotensive after surgery, showed a renal plasma flow (RPF) of less than 200 ml/min in the contralateral kidney preoperatively.
Cineplastic Operations on Stumps of the Upper Extremity
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diversifying preclinical research tools: expanding patient-derived models to address cancer health disparities
Authors: Nicole B. Halmai, Luis G. Carvajal-Carmona
Journal: Trends in cancer (2022)

Cancer health disparities define a critical healthcare issue for racial/ethnic minorities in the USA. Key findings have led to cancer treatment improvements tailored to minority patients, but such successes have been rare. Here, we highlight how the use of patient-derived xenograft (PDX) and organoid models could resolve current blocks toward precision cancer health equity.
Trastuzumab Deruxtecan Data Impresses at ESMO
Journal: Cancer Discovery (2021)

The DESTINY-Breast03 study, a randomized, phase III trial pitting the antibody-drug conjugates trastuzumab emtansine and trastuzumab deruxtecan against each other in HER2+ metastatic breast cancer, found remarkable improvements in efficacy and safety for the latter, newer therapy.
Rituximab in ANCA-Associated Disease
Authors: Julie Lin, Holly Kramer
Journal: New England Journal of Medicine (2010)

on death rates in healthy control subjects who do not have any chronic medical conditions that would exclude living kidney donation.However, an important caveat is that criteria for living kidney donors are likely to change over time.A 2007 survey of U.S. transplantation centers reported that as compared with data from 1995, 3 centers were accepting an increased number of potential donors who were older or had hypertension.
Commentaire de travail de T. Matysiak-Budnik et al., pp. 191
Journal: Endoscopy (2010)

See also:Narrow band imaging for detecting superficial squamous cell carcinoma of the head and neck in patients with esophageal squamous cell carcinomaEndoscopy 2010; 42(03): 185-190DOI: 10.1055/s-0029-1243963
Psychological Distress in Men With Breast Cancer
Authors: Kate Brain, Buddug Williams, Rachel Iredale, Liz France, Jonathon Gray
Journal: Journal of Clinical Oncology (2005)

Purpose This article reports the first United Kingdom study to examine the prevalence of psychological distress in men with breast cancer and the factors associated with increased distress. Patients and Methods One hundred and sixty-one men with breast cancer completed a cross-sectional questionnaire that included measures of anxiety and depressive symptoms, cancer-specific distress, body image, coping, information and support needs, and clinical and demographic variables. Results Clinical levels of anxiety and depressive symptoms were reported by 6% and 1% of men, respectively, while 23% reported high levels of cancer-specific distress. Anxiety was most strongly associated with avoidance coping and fear and uncertainty about the future (42% of the variance in anxiety scores, P &lt; .001). Depressive symptoms were associated with altered body image (35% of the variance, P &lt; .001). Body image, avoidance coping, referral to the study by a clinician, fear and uncertainty, and wanting to receive more gender-specific information together explained 51% of the variance in cancer-related distress (P &lt; .001). Clinical and demographic factors did not account for a significant proportion of the variance in any of the distress measures. Conclusion Although the prevalence of clinical anxiety and depressive symptoms were low in this sample, almost a quarter of men experienced traumatic stress symptoms specific to breast cancer. Potential risk factors for distress include the use of avoidant coping strategies, negative body image, feelings of fear and uncertainty in relation to breast cancer, and unmet information needs. Suggestions are made for improving the information and support available to men with breast cancer.
Optimization of endoloop closure for gastric endoscopic submucosal dissection defects with a bead: the bead, loop, and clips technique
Authors: Yuka Kowazaki, Anastassios Manolakis, Hisashi Fukuda, Itaru Saito, Tetsurou Miwata, Sawako Fujikura, Takaaki Morikawa
Journal: Endoscopy (2022)

Endoscopic closure of endoscopic submucosal dissection (ESD)-induced gastric defects using an endoloop and endoclips may prevent delayed bleeding in patients who are receiving anticoagulants [1]. Several technical variations of the endoloop and endoclips technique have been described, some of which also use single-channel endoscopes [2], which are in widespread use. Their successful application is however being undermined by a number of pitfalls, both procedure-related (e. g. respiratory fluctuations, poor endoloop device maneuverability when kept outside the endoscope) and instrument-related (e. g. difficulty grasping the tail or stem of the endoloop, resulting from the hooked shape of the device) [3]. Herein, we illustrate a modification of the endoloop and endoclips technique, inspired by the “loop 9” method [4], that can be applied as a less cumbersome yet effective alternative to similar procedures.
Azacitidine-induced reconstitution of the bone marrow T cell repertoire is associated with superior survival in AML patients
Authors: Juliane Grimm, Donjete Simnica, Nadja Jäkel, Lisa Paschold, Edith Willscher, Susann Schulze, Christine Dierks, Haifa Kathrin Al-Ali, Mascha Binder
Journal: Blood Cancer Journal (2022)

Abstract Hypomethylating agents (HMA) like azacitidine are licensed for the treatment of acute myeloid leukemia (AML) patients ineligible for allogeneic hematopoietic stem cell transplantation. Biomarker-driven identification of HMA-responsive patients may facilitate the choice of treatment, especially in the challenging subgroup above 60 years of age. Since HMA possesses immunomodulatory functions that constitute part of their anti-tumor effect, we set out to analyze the bone marrow (BM) immune environment by next-generation sequencing of T cell receptor beta ( TRB ) repertoires in 51 AML patients treated within the RAS-AZIC trial. Patients with elevated pretreatment T cell diversity (11 out of 41 patients) and those with a boost of TRB richness on day 15 after azacitidine treatment (12 out of 46 patients) had longer event-free and overall survival. Both pretreatment and dynamic BM T cell metrics proved to be better predictors of outcome than other established risk factors. The favorable broadening of the BM T cell space appeared to be driven by antigen since these patients showed significant skewing of TRBV gene usage. Our data suggest that one course of AZA can cause reconstitution to a more physiological T cell BM niche and that the T cell space plays an underestimated prognostic role in AML. Trial registration : DRKS identifier: DRKS00004519
The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling
Authors: Axel R. Concepcion, Larry E. Wagner, Jingjie Zhu, Anthony Y. Tao, Jun Yang, Alireza Khodadadi-Jamayran, Yin-Hu Wang, Menghan Liu, Rebecca E. Rose, Drew R. Jones, William A. Coetzee, David I. Yule, Stefan Feske
Journal: Nature Immunology (2022)
The Metabolic Role and Therapeutic Potential of the Microbiome
Authors: Louise E Olofsson, Fredrik Bäckhed
Journal: Endocrine Reviews (2022)

We are host to an assembly of microorganisms that vary in structure and function along the length of the gut and from the lumen to the mucosa. This ecosystem is collectively known as the gut microbiota and significant efforts have been spent during the past 2 decades to catalog and functionally describe the normal gut microbiota and how it varies during a wide spectrum of disease states. The gut microbiota is altered in several cardiometabolic diseases and recent work has established microbial signatures that may advance disease. However, most research has focused on identifying associations between the gut microbiota and human diseases states and to investigate causality and potential mechanisms using cells and animals. Since the gut microbiota functions on the intersection between diet and host metabolism, and can contribute to inflammation, several microbially produced metabolites and molecules may modulate cardiometabolic diseases. Here we discuss how the gut bacterial composition is altered in, and can contribute to, cardiometabolic disease, as well as how the gut bacteria can be targeted to treat and prevent metabolic diseases.
In-hospital and late outcomes following primary stenting in acute myocardial infarction — comparison with primary PTCA
Authors: G.W. Stone, B. Brodie, J. Griffin, M.C. Morico, F.S. Goar, C. Costantini, P.A. Overlie, J. McDonnell, W.W. O'Neill, C.L. Grines
Journal: Journal of the American College of Cardiology (1998)
Nordisk Medicin, Stockholm
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Increased expression of HOXA11-AS attenuates endometrial decidualization in recurrent implantation failure patients
Authors: Hanting Zhao, Shuanggang Hu, Jia Qi, Yuan Wang, Ying Ding, Qinling Zhu, Yaqiong He, Yao Lu, Yue Yao, Shiyao Wang, Yanzhi Du, Yun Sun
Journal: Molecular Therapy (2022)

Endometrial decidualization is a prerequisite for implantation, and impaired decidualization is associated with recurrent implantation failure (RIF). Coding genes of the HOX family have been clarified as critical regulators in endometrial decidualization, but the role of long non-coding RNAs (lncRNAs) in the HOX gene family has yet to be determined. The aim of this study was to clarify the possible roles of lncRNAs in the HOX gene family in decidualization. In this study, we identified that HOXA11-AS was the most reduced lncRNA in the HOX family in the human endometrium during the window of implantation, and it was elevated in RIF patients. Mechanistically, HOXA11-AS negatively regulated decidualization through competitive interaction with PTBP1, an RNA-binding protein. Binding of PTBP1 to HOXA11-AS limited PTBP1 availability to regulate PKM1/2 alternative splicing, resulting in enhanced PKM1 and diminished PKM2 expression, thus attenuating decidualization. The pattern of high HOXA11-AS expression and impaired PKM2 splicing was consistently observed in RIF patients. Collectively, our study indicates that the increase of HOXA11-AS is detrimental to endometrial decidualization, likely contributing to RIF. Our study may shed light on the pathogenesis and treatment of RIF. Endometrial decidualization is a prerequisite for implantation, and impaired decidualization is associated with recurrent implantation failure (RIF). Coding genes of the HOX family have been clarified as critical regulators in endometrial decidualization, but the role of long non-coding RNAs (lncRNAs) in the HOX gene family has yet to be determined. The aim of this study was to clarify the possible roles of lncRNAs in the HOX gene family in decidualization. In this study, we identified that HOXA11-AS was the most reduced lncRNA in the HOX family in the human endometrium during the window of implantation, and it was elevated in RIF patients. Mechanistically, HOXA11-AS negatively regulated decidualization through competitive interaction with PTBP1, an RNA-binding protein. Binding of PTBP1 to HOXA11-AS limited PTBP1 availability to regulate PKM1/2 alternative splicing, resulting in enhanced PKM1 and diminished PKM2 expression, thus attenuating decidualization. The pattern of high HOXA11-AS expression and impaired PKM2 splicing was consistently observed in RIF patients. Collectively, our study indicates that the increase of HOXA11-AS is detrimental to endometrial decidualization, likely contributing to RIF. Our study may shed light on the pathogenesis and treatment of RIF.
Update: Trends in AIDS Among Men Who Have Sex With Men—United States, 1989-1994
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Renal scanning
Authors: A. Gottschalk
Journal: JAMA (1967)

In spite of extensive efforts by several investigators in the late 1950's to perfect "in transit" scanning of continuously excreted contrast agents labeled with radioactive iodine (<sup>131</sup>I), renal scanning did not become a popular procedure until the introduction of chlormerodrin Hg 203. With this material, approximately 60% of the injected dose is in the kidneys within one to two hours. Although the agent is eventually excreted so that only about 10% ultimately remains fixed in the renal parenchyma, the excretion is slow. As a result, at one hour, renal scanning can be done with assurance that the renal isotope concentration will remain reasonably constant throughout the scan. Since all the renal scanning agents currently in use localize in the renal parenchyma (principally in the cortex), the scan has been used to (1) identify the degree of parenchymal function—often possible when the kidneys are not visualized on intravenous pyelograms; (2)
CCR7-guided neutrophil redirection to skin-draining lymph nodes regulates cutaneous inflammation and infection
Authors: A. Özcan, V. Collado-Diaz, C. Egholm, M. Tomura, M. Gunzer, C. Halin, A. G. A. Kolios, O. Boyman
Journal: Science Immunology (2022)

Neutrophils are the first nonresident effector immune cells that migrate to a site of infection or inflammation; however, improper control of neutrophil responses can cause considerable tissue damage. Here, we found that neutrophil responses in inflamed or infected skin were regulated by CCR7-dependent migration and phagocytosis of neutrophils in draining lymph nodes (dLNs). In mouse models of Toll-like receptor-induced skin inflammation and cutaneous Staphylococcus aureus infection, neutrophils migrated from the skin to the dLNs via lymphatic vessels in a CCR7-mediated manner. In the dLNs, these neutrophils were phagocytosed by lymph node-resident type 1 and type 2 conventional dendritic cells. CCR7 up-regulation on neutrophils was a conserved mechanism across different tissues and was induced by a broad range of microbial stimuli. In the context of cutaneous immune responses, disruption of CCR7 interactions by selective CCR7 deficiency of neutrophils resulted in increased antistaphylococcal immunity and aggravated skin inflammation. Thus, neutrophil homing to and clearance in skin-dLNs affects cutaneous immunity versus pathology.
Erratum: Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence
Authors: Suzanne Sniekers, Sven Stringer, Kyoko Watanabe, Philip R Jansen, Jonathan R I Coleman, Eva Krapohl, Erdogan Taskesen, Anke R Hammerschlag, Aysu Okbay, Delilah Zabaneh, Najaf Amin, Gerome Breen, David Cesarini, Christopher F Chabris, William G Iacono, M Arfan Ikram, Magnus Johannesson, Philipp Koellinger, James J Lee, Patrik K E Magnusson, Matt McGue, Mike B Miller, William E R Ollier, Antony Payton, Neil Pendleton, Robert Plomin, Cornelius A Rietveld, Henning Tiemeier, Cornelia M van Duijn, Danielle Posthuma
Journal: Nature Genetics (2017)
S115: LONG-TERM EFFICACY AND SAFETY OF DEFERIPRONE FOR PATIENTS WITH SICKLE CELL DISEASE OR OTHER ANEMIAS
Authors: B Inusa, M Hamdy, A El-Beshlawy, F Ebeid, J Kwiatkowski, J Kanter, S Williams, D Lee, N Temin, C Fradette, F Tricta, M Elalfy
Journal: HemaSphere (2022)

Background: FIRST-EXT was a prospective, multicenter, single-arm, open-label extension of the FIRST study in patients with sickle cell disease (SCD) and other transfusion-dependent anemias. In FIRST, patients were randomly assigned 2:1 to receive oral deferiprone (DFP) or parenteral deferoxamine (DFO) for 12 months. The noninferiority of DFP versus DFO was previously reported.1 Here we report the efficacy and safety of DFP in FIRST-EXT. Aims: To evaluate the long-term efficacy and safety of DFP in iron-overloaded patients with SCD or other anemias. Methods: Patients who completed FIRST could enter FIRST-EXT for up to 2 years. Patients previously treated with DFP continued on DFP (DFP-DFP), while those previously treated with DFO were switched to DFP (DFO-DFP). Baseline was defined as the start of FIRST for DFP-DFP patients, and the start of FIRST-EXT for DFO-DFP patients. Efficacy endpoints were yearly changes from baseline in liver iron concentration (LIC), cardiac MRI T2*, and serum ferritin (SF). We also report adverse drug reactions (ADRs), defined as adverse events at least possibly related to DFP. All patients provided informed consent or assent. Results: Patients (N=134: 89 DFP-DFP; 45 DFP-DFO) were 60.4% male, with a mean (SD) age of 16.2 (8.6) years. Most (85.8%) had SCD; 14.2% had other anemias. At baseline, all patients had elevated (≥1.8 mg/g dry weight [dw]) LIC; all but one had elevated (females >300 µg/L, males >400 µg/L) SF; and all had cardiac MRI T2* in the normal range (≥20 ms). A significant, progressive decline was seen in LIC, with mean (SD) changes from baseline to years 1, 2, and 3 of -2.64 (4.64), -3.91 (6.38), and -6.64 (7.72) mg/g dw, respectively (P<0.01 for all). A decline was also seen in SF, with mean (SD) changes from baseline to years 1, 2, and 3 of -1 (1986), -771 (2171), and -1016 (3617) µg/L, respectively (P<0.05 for years 2 and 3). Cardiac MRI T2* values changed little from baseline. The most frequent ADRs were neutropenia (9.0%), decreased neutrophil count (9.0%), and abdominal pain (7.5%); 2 patients (1.5%) experienced agranulocytosis. One patient withdrew due to ADRs of thrombocytopenia and neutropenia, which resolved. Another patient withdrew due to generalized edema and died for reasons unknown 17 days after withdrawal from the study. Conclusions: DFP long-term use (≤3 years) was effective in controlling body iron load in patients with SCD and other anemias. There were no new safety concerns. References 1. Kwiatkowski et al, Blood 2019; 134 (Supplement 1): 618.
Disease Burden Among Patients With Multiple Overlapping Eosinophilic Diseases In The Real World Investigation Of Eosinophilic-Associated Disease Overlap (REVEAL) Study
Authors: Justin Kwiatek, Anamaria Brailean, Danuta Kielar, Rohit Katial, Xia Wang, Xiao Xu, Sharon MacLachlan, Yong Jin Kim, Michael Stokes, Heide Stirnadel Farrant
Journal: Journal of Allergy and Clinical Immunology (2022)
A full complement of receptors in immune complex diseases
Authors: Jeffrey V. Ravetch
Journal: Journal of Clinical Investigation (2002)

In this issue of the JCI, Shushakova et al.(1) describe experimental results that provide a direct link between the C5a anaphylotoxin and the IgG Fc receptors (FcγRs) in mediating immune complex-triggered (IC-triggered) inflammatory disease.Using a murine lung model of IC-induced inflammation, the authors demonstrate that C5a, acting through the C5a receptor (C5aR), exacerbates inflammation in part by altering the ratio of activation to inhibitory FcγR expression on alveolar macrophages, enhancing the former and suppressing the latter, thereby optimizing the ability of alveolar macrophages to respond to ICs and trigger cytokine release and neutrophil chemotaxis.C5a now joins the ranks of other regulators of FcγR expression, such as IFN-γ and intravenous immunoglobulin (IVIG), in modulating IC-induced inflammation by acting on the primary IC targets, the FcγRs.What makes this observation worthy of comment is the historical context of IC-mediated inflammation and the confusion that has surrounded the basic mechanism of this fundamental immunological reaction, the Arthus reaction.