tbuckley/cabot-search huggingface dataset:
(13) Lupus erythematosus profundus
Authors: A.E. Walker
Journal: British Journal of Dermatology (1986)

Journal Article (13) Lupus erythematosus profundus Get access A.E. Walker, Dr A.E. Walker, Dr Chesterfield and North Derbyshire Royal Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 115, Issue s30, 1 July 1986, Pages 55–56, https://doi.org/10.1111/j.1365-2133.1986.tb07708.x Published: 01 July 1986
Strongyloidiasis in ex-Far East prisoners of war
Authors: J A Hill
Journal: BMJ (1988)

with conventional cuprophane membranes.4Haemodialysis with high flux dialysers and polysulfone or polyacrylonitrile membranes lowers t32 microglobulin concentrations, and an improvement in shoulder pain in patients changed to high flux dialysers has been reported.5The mechanism of the improvement is not clear; possibly amyloid is no longer deposited and the associated inflammation decreases.The improved biocompatibility of these membranes is known to be associated with reduced activation of some mediators of the inflammatory response.Our patient used polysulfone dialysers after his operation, and his initial improvement was maintained.Monitoring the amyloid deposits throughout his spinal canal should show the effect of high flux dialysis on further deposition of amyloid.
Intrinsic washout rates of thallium-201 in normal and ischemic myocardium after dipyridamole-induced vasodilation.
Authors: G ABeller, H HHolzgrefe, D DWatson
Journal: Circulation (1985)

Infusion of dipyridamole has been suggested as an alternative to exercise stress for myocardial perfusion imaging for detection of ischemia, but the mechanism and significance of thallium-201 (201Tl) redistribution after administration of dipyridamole are uncertain. If disparate intrinsic cellular efflux rates of 201Tl from normal and relatively underperfused myocardium in response to dipyridamole-induced vasodilation were observed, this could explain delayed 201Tl redistribution. We investigated eht effect of an intravenous infusion of 0.15 mg/kg dipyridamole on the intrinsic myocardial washout rate of 201Tl as measured with a gamma-detector probe after intracoronary injection (50 muCi) of the radionuclide in open-chested anesthetized dogs. In six normal dogs the t 1/2 for intrinsic 201Tl washout from the myocardium was 89 +/- 11 min (SE) at control conditions and became more rapid at 59 +/- 10 min (p = .0001) after dipyridamole. This corresponded to a significant increase in microsphere-determined epica...
Genetic epidemiology of SARS-CoV-2 transmission in renal dialysis units – A high risk community-hospital interface
Authors: Kathy K. Li, Y. Mun Woo, Oliver Stirrup, Joseph Hughes, Antonia Ho, Ana Da Silva Filipe, Natasha Johnson, Katherine Smollett, Daniel Mair, Stephen Carmichael, Lily Tong, Jenna Nichols, Elihu Aranday-Cortes, Kirstyn Brunker, Yasmin A. Parr, Kyriaki Nomikou, Sarah E. McDonald, Marc Niebel, Patawee Asamaphan, Vattipally B Sreenu, David L. Robertson, Aislynn Taggart, Natasha Jesudason, Rajiv Shah, James Shepherd, Josh Singer, Alison H.M. Taylor, Zoe Cousland, Jonathan Price, Jennifer S. Lees, Timothy P.W. Jones, Carlos Varon Lopez, Alasdair MacLean, Igor Starinskij, Rory Gunson, Scott T.W. Morris, Peter C. Thomson, Colin C. Geddes, Jamie P. Traynor, Judith Breuer, Emma C. Thomson, Patrick B. Mark
Journal: Journal of Infection (2021)

Patients requiring haemodialysis are at increased risk of serious illness with SARS-CoV-2 infection. To improve the understanding of transmission risks in six Scottish renal dialysis units, we utilised the rapid whole-genome sequencing data generated by the COG-UK consortium.
Effects of intracellular acidification on membrane currents in ventricular cells of the guinea pig.
Authors: RSato, ANoma, YKurachi, HIrisawa
Journal: Circulation Research (1985)

The membrane currents of single ventricular cells were measured under whole cell voltage clamp using a giga-sealed patch electrode, and the effects of intracellular acidification were examined by perfusing the electrode pipette with different pH solutions. The plateau of the action potential was shortened when the pH of the pipette solution was lowered from the control of 7.2 to 6, and finally to 5. The pH 6 pipette solution evoked a time-independent outward current at positive potentials and increased the slope conductance near the resting potential. These changes were suppressed by removal of both intra- and extracellular potassium ion, indicating that these currents were carried by potassium ions, but not by protons. Increasing the calcium concentration in the pipette from pCa 8 to pCa 6 induced a time-dependent outward current which had a reversal potential of about -13 mV. This result clearly differed from the changes induced by the acidic pipette solution, suggesting that the calcium-mediated conduc...
Immune Deficiency Syndrome in Children
Authors: James Oleske
Journal: JAMA (1983)

The present epidemic of acquired immune deficiency syndrome (AIDS) was originally described in homosexual men and subsequently in intravenous drug abusers, Haitians, and hemophiliacs. Profound defects in cell-mediated immunity (CMI) are associated with Kaposi's sarcoma and a variety of serious opportunistic infections. Recently, we and others have encountered a group of children with an otherwise unexplained immune deficiency syndrome and infections of the type found in adults with AIDS. In this report, we describe eight children from the Newark, NJ, metropolitan area born into families with recognized risks for AIDS. These patients have had recurrent febrile illnesses, failure to thrive, hypergammaglobulinemia, and depressed CMI. Four of these children have died. Our experience suggests that children living in high-risk households are susceptible to AIDS and that sexual contact, drug abuse, or exposure to blood products is not necessary for disease transmission.
Clinical and prognostic importance of persistent precordial (V1-V4) electrocardiographic ST segment depression in patients with inferior transmural myocardial infarction.
Authors: N JLembo, M RStarling, L JDell'Italia, M HCrawford, T KChaudhuri, R AO'Rourke
Journal: Circulation (1986)

Forty-three consecutive patients with acute inferior transmural myocardial infarction but no history or electrocardiographic evidence of prior myocardial infarction were evaluated prospectively to assess the clinical and prognostic importance of persistent precordial (V1-V4) ST segment depression. Patients were evaluated within 24 hr of admission by history, physical examination, cardiac enzyme levels, right heart catheterization, and radionuclide angiography; all were followed for 1 year. Ten of the 43 patients (group I) had persistent anterior precordial ST segment depression, defined as 1 mm or greater in one or more precordial leads (V1-V4) 24 hr after admission to the coronary care unit, and 33 patients (group II) did not. Clinical variables that differed between groups I and II, respectively, included mean age (67 +/- 9 [+/- 1 SD] vs 59 +/- 8 years; p less than .01), incidence of Killip class II to IV (100% vs 33%; p less than .001), and average peak creatine kinase concentration (2878 +/- 1139 vs 1...
Dispersion of the QT interval. A marker of therapeutic efficacy in the idiopathic long QT syndrome.
Authors: S GPriori, CNapolitano, LDiehl, P JSchwartz
Journal: Circulation (1994)

BACKGROUNDQT interval dispersion, measured as interlead variability of QT, is a marker of dispersion of ventricular repolarization and, hence, of cardiac electrical instability. We tested the hypothesis that dispersion of ventricular repolarization may be differently affected by interventions destined to provide complete or incomplete protection against malignant arrhythmias in patients with long QT syndrome (LQTS). Twenty-eight patients affected by the Romano Ward form of LQTS entered the study and were divided into three groups: LQTS patients before institution of therapy, patients who did respond to beta-blocker therapy, and patients who continued to have syncope and cardiac arrest despite beta-blockade and who underwent left cardiac sympathetic denervation. A group of 15 healthy volunteers served as control subjects.METHODS AND RESULTSDispersion of QT and QTc were calculated using two indexes: the difference between the longest and the shortest value measured in each of the 12 ECG leads (QTmax-QTmin, ...
Nonadrenergic noncholinergic innervation. Anatomic distribution of calcitonin gene-related peptide-immunoreactive tissue in the dog heart.
Authors: P CUrsell, C LRen, AAlbala, PDanilo
Journal: Circulation Research (1991)

Calcitonin gene-related peptide (CGRP) has inotropic and chronotropic effects in rat and guinea pig hearts. It also may mediate nonadrenergic noncholinergic regulation of canine cardiac electrophysiology. In this study, immunohistochemistry was used to determine the anatomic distribution of CGRP in mature dog heart and autonomic ganglia controlling cardiac function. The stellate ganglia had scattered CGRP-immunoreactive cells and nerve processes; intracardiac ganglia contained stained nerve processes but no CGRP-immunoreactive cells. Although the extramural coronary arteries were modestly innervated by varicose individual nerve processes, the great majority of CGRP-immunoreactive neural tissue in the heart existed adjacent to the sinoatrial node where varicose nerve processes coursed in numerous large nerve bundles. Each bundle contained only a few stained processes, however, indicating that CGRP-immunoreactive nerve processes were accompanying another type of autonomic tissue. Double staining and immunou...
Evidence for the existence of inositol tetrakisphosphate in mammalian heart. Effect of alpha 1-adrenoceptor stimulation.
Authors: CKohl, WSchmitz, HScholz, JScholz
Journal: Circulation Research (1990)

The time course of the effects of phenylephrine (10 mumol/l) on force of contraction and on inositol phosphates in electrically driven left auricles from rat hearts labeled with [3H]inositol was studied. All experiments were performed in the presence of propranolol (1 mumol/l) and LiCl (10 mmol/l). Products measured after separation with high-performance liquid chromatography were inositol 1-phosphate (1-IP1), inositol 1,4-bisphosphate (1,4-IP2), inositol 1,3,4-trisphosphate (1,3,4,-IP3), inositol 1,4,5-trisphosphate (1,4,5-IP3), and inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-IP4). All inositol phosphates increased after stimulation with phenylephrine. 1,4,5-IP3 was the first compound to rise maximally within 30 seconds; this rise was followed by an increase in 1,3,4,5-IP4 and 1,4-IP2 beginning within 2 minutes. The increase in 1,3,4-IP3 and 1-IP1 was slower and did not reach steady state within 15 minutes. The positive inotropic effect of phenylephrine was maximal after 5 minutes. It is concluded that t...
The role of RNA processing and regulation in metastatic dormancy
Authors: Kimberly A. Parker, Nathaniel J. Robinson, William P. Schiemann
Journal: Seminars in Cancer Biology (2021)

Tumor dormancy is a major contributor to the lethality of metastatic disease, especially for cancer patients who develop metastases years-to-decades after initial diagnosis. Indeed, tumor cells can disseminate during early disease stages and persist in new microenvironments at distal sites for months, years, or even decades before initiating metastatic outgrowth. This delay between primary tumor remission and metastatic relapse is known as "dormancy," during which disseminated tumor cells (DTCs) acquire quiescent states in response to intrinsic (i.e., cellular) and extrinsic (i.e., microenvironmental) signals. Maintaining dormancy-associated phenotypes requires DTCs to activate transcriptional, translational, and post-translational mechanisms that engender cellular plasticity. RNA processing is emerging as an essential facet of cellular plasticity, particularly with respect to the initiation, maintenance, and reversal of dormancy-associated phenotypes. Moreover, dysregulated RNA processing, particularly that associated with alternative RNA splicing and expression of noncoding RNAs (ncRNAs), can occur in DTCs to mediate intrinsic and extrinsic metastatic dormancy. Here we review the pathophysiological impact of alternative RNA splicing and ncRNAs in promoting metastatic dormancy and disease recurrence in human cancers.
Reply to Alessia Cimadamore, Antonio Lopez-Beltran, Marina Scarpelli, and Rodolfo Montironi’s Letter to the Editor re: Timothy D. Jones, Liang Cheng. Histologic Grading of Bladder Tumors: Using Both the 1973 and 2004/2016 World Health Organization Systems in Combination Provides Valuable Information for Establishing Prognostic Risk Groups. Eur Urol 2021;79:489–91
Authors: Timothy D. Jones, Liang Cheng
Journal: European Urology (2021)
Abstract 15311: Drivers Associated With Dense Fibrotic Regions Are Critical Targets in Extra-Pulmonary Vein Ablation in Persistent Atrial Fibrillation
Authors: Megan M Subr, Uma Mylavarapu, Lisa Hoenie, Allison Wilson, Katelynn M Helfrich, Brian Hansen, Aleksei Mikhailov, Yue Pan, Aaqel Nalar, James Kennelly, Jichao Zhao, Orlando Simonetti, John Hummel, Vadim V Fedorov
Journal: Circulation (2020)

Background: Multielectrode mapping (MEM) of extra-pulmonary vein (PV) targeted ablation of persistent atrial fibrillation (PsAF) drivers suffers from false positives. Early studies suggest that true AF drivers are anchored to arrhythmogenic fibrosis, which can be visualized with late gadolinium enhanced (LGE) cardiac magnetic resonance (CMR) to distinguish them from false positive drivers on MEM. Hypothesis: Driver regions integral to AF correlate with high atrial fibrosis; therefore, ablation of MEM-defined drivers within fibrotic regions may lead to better outcomes than MEM-defined drivers outside fibrosis. Methods: Pre-ablation, 10 PsAF patients (Pts) (70% male; 65±11 y/o) underwent LGE-CMR at 3T (0.625x0.625x1.25mm 3 , 0.2mmol/kg gadolinium). During ablation, MEM (64-electrode basket catheter) was used to identify Pt-specific extra-PV drivers. Retrospectively, both left (LA) and right atria (RA) were analyzed with atria-specific fibrosis masks (voxels exceeding an intensity of 3-3.5 standard deviations above the mean intensity of nonfibrotic atrial wall). Ablated drivers were classified as fibrotic driver (dense or patchy) or nonfibrotic driver by LGE-CMR and MEM correlation. Results: 30 drivers were ablated in 10 PsAF Pts (2±1 LA drivers/Pt, 1±1 RA drivers/Pt) and were classified if anchored to dense (n=16, 45.4±31.7%, 2.6±1.8cm 2 ), patchy (n=11, 8.9±13.5%, 2.0±2.5cm 2 ), or no (n=3, 2.3±2.0%) fibrosis. At follow-up (13±7 mos), 7/10 Pts remained free from AF and atrial flutter, all of whom had at least one dense fibrosis driver ablated and all but 1 Pt had ablations limited to fibrotic drivers. 2/3 patients with failure at follow-up had a nonfibrotic driver ablated. Conclusion: Our results suggest that limiting ablation of AF drivers to those anchored to dense fibrotic substrate may improve long-term AF-free survival. Identification of Pt-specific fibrotic substrate by LGE-CMR may help specificity of MEM ablation targets for successful PsAF treatment.
Higher antioxidative capacity during a chronic stable heart hypertrophy.
Authors: MGupta, P KSingal
Journal: Circulation Research (1989)

Changes in oxygen radical mechanisms during 6-48 weeks of heart hypertrophy in rats subjected to a narrowing of the subdiaphragmatic aorta were examined. During this period, hypertrophied hearts demonstrated a stable hyperfunction, as indicated by an elevated but stable left ventricular systolic pressure, dP/dt, and aortic pressure and no change in left ventricular end diastolic pressure. Experimental animals showed increased heart-to-body weight ratios; however, the conventional signs of heart failure such as increased wet-to-dry weight ratios of liver and lung, ascites, or pleural effusion were absent. Hearts were examined for superoxide dismutase, glutathione peroxidase, and lipid peroxide activities. The superoxide dismutase activity was significantly higher in hypertrophied hearts at 6 and 12 weeks as compared with sham-operated rats (sham controls), while no difference was seen at 24 and 48 weeks due to a marked increase in the superoxide dismutase activity of sham control hearts in these age groups...
Studies in vitro of the relationship between ultrasound and laser Doppler velocimetry and applicability to the simplified Bernoulli relationship.
Authors: L MValdes-Cruz, A PYoganathan, TTamura, FTomizuka, Y RWoo, D JSahn
Journal: Circulation (1986)

While there has been wide general acceptance of Doppler methods that use the simplified Bernoulii relationship to estimate pressure gradients across stenotic orifices, there is still ongoing controversy related to potential sources of error in the method. In this study we tested accuracy o ultrasound Doppler measurements of flow velocity when compared with the gold standard of laser light Doppler anemometry in a pulsatile flow model of pulmonic stenosis in vitro. We tested two commercially available Doppler systems and examined steered and nonsteered, parallel and off-axis and angle-corrected velocity determinations using continuous-wave and high-pulse repetition frequency (HPRF) methods. We also examined the potential range of error in the simplified Bernoulli method. One hundred and twenty individual flow states were examined with three stenotic valve orifices (3.0, 1.0, and 0.5 cm2 flow area) to measure velocities up to 620 cn/sec. A very high correlation coefficient was obtained for the comparison of ...
Endoscopic Management of Benign Esophageal Strictures:
Authors: S Bradai, A Khsiba, M Mahmoudi, A Nakhli, M Medhioub, A Ben Mohamed, L Hamzaoui, MM Azouz
Journal: Endoscopy (2021)

Aims Benign esophageal strictures are a rare condition. Endoscopic dilation remains the gold standard. The purpose of our study is to report our experience in the management of benign esophageal strictures.
Properties of single outwardly rectifying Cl- channels in heart.
Authors: DDuan, SNattel
Journal: Circulation Research (1994)

A variety of potentially important macroscopic Cl- currents have been described in the heart. Although the single-channel properties of the cAMP-dependent current (ICl.cAMP) have been well described, the single-channel equivalents of the other forms of cardiac Cl- current remain unknown. Unlike ICl.cAMP, many of these currents show prominent outward rectification in the presence of symmetrical transmembrane Cl- gradients and sensitivity to disulfonic stilbene Cl- transport blockers. We used the patch-clamp technique to search for single Cl- channels in inside-out patches from rabbit atrial cell membranes, under conditions minimizing the chances of observing channels carrying Na+, Ca2+, or K+. Under symmetrical Cl- conditions, single-channel activity was seen in 14 (9%) of 155 patches. Channels showed strong outward rectification and a unitary conductance of 60 +/- 3 picosiemens (mean +/- SEM) at positive voltages. The current-voltage relation was not altered by replacement of cations by the impermeant cat...
Residents' Work Hours
Authors: Sarang Kim
Journal: Annals of Internal Medicine (2004)

Letters2 November 2004Residents' Work HoursSarang Kim, MDSarang Kim, MDFrom University of Medicine and Dentistry of New Jersey–Robert Wood Johnson Medical School, New Brunswick, NJ 08903.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-9-200411020-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I disagree with Dr. Charap's argument that the new work hour regulations for residents are “harmful to the future of our profession” (1). Dr. Charap believes that the new system suggests continuity is not important and rewards unprofessional behavior. What he fails to recognize is that the ACGME regulates work hours, not professionalism. Setting a standard for professional attitude and behavior is the responsibility of all of us in the profession. While the new work hour regulations undoubtedly present a significant challenge for program directors nationwide, they also bring new opportunities for medical educators to take an ...Reference1. Charap M. Reducing resident work hours: unproven assumptions and unforeseen outcomes. Ann Intern Med. 2004;140:814-5. [PMID: 15148068] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Medicine and Dentistry of New Jersey–Robert Wood Johnson Medical School, New Brunswick, NJ 08903. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoReducing Resident Work Hours: Unproven Assumptions and Unforeseen Outcomes Mitchell Charap Benefits of Resident Work Hours Regulation Kelley M. Skeff , Stephen Ezeji-Okoye , Peter Pompei , and Stanley Rockson The Effect of Work Hour Regulations on Personal Development during Residency Melinda E. Glines How Many Hours Is Enough? An Old Profession Meets a New Generation Steven A. Schroeder Residents' Work Hours Timothy Lahey Residents' Work Hours Yungpo Bernard Su and Lydia Kang Residents' Work Hours Ilene M. Rosen , Judy A. Shea , and Lisa M. Bellini Residents' Work Hours Mitchell Charap Residents' Work Hours Gabriella Varallo Bedarida Metrics 2 November 2004Volume 141, Issue 9Page: 740-741KeywordsBehaviorForecasting ePublished: 2 November 2004 Issue Published: 2 November 2004 CopyrightCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Hormonal and nutritional substrate control of cardiac lysosomal enzyme activities.
Authors: KWildenthal
Journal: Circulation Research (1976)

Prolonged starvation is known to induce significant alterations in several cardiac lysosomal enzymes, particularly the acid proteinase cathepsin D. To determine what specific factors might mediate these changes, fetal mouse hearts in organ culture were maintained in media designed to simulate selected hormonal or nutritional substrate changes that accompany starvation. Reduced concentrations of glucose caused an increase in the activity of beta-acetylglucosaminidase but had no effect on cathepsin D or acid phosphatase activites (i.e., effects opposite from those of starvation). Also, high concentrations of free fatty acid, acetoacetate, and beta-OH-butyrate induced an increase in cathepsin D (+18%) and a simultaneous decrease in glucosaminidase (-19%), with little change in acid phosphatase. Furthermore, glucagon had no effect on any of the enzymes, whereas growth hormone caused a small (6%) increase in cathepsin D activity. In addition, insulin deprivation caused significant increases (7-25%) in the acti...
Determination of parameters of left ventricular diastolic filling with pulsed Doppler echocardiography: comparison with cineangiography.
Authors: RRokey, L CKuo, W AZoghbi, M CLimacher, M AQuinones
Journal: Circulation (1985)

To determine the relationship between Doppler-derived flow velocity through the mitral anulus and angiographic parameters of left ventricular filling, 30 patients were studied by two-dimensional echocardiography combined with pulsed Doppler echocardiography followed within 1 hr by left ventricular angiography. The average heart rate for each test was 69 beats/min. Doppler-derived parameters included: early peak diastolic velocity (E) and peak atrial velocity, peak filling rate computed as E X cross-sectional area of the mitral anulus derived from the annular diameter, normalized peak filling rate computed as peak filling rate divided by the left ventricular end-diastolic volume determined by two-dimensional echocardiography, and half filling fraction derived from the time-velocity integral of the Doppler-determined velocity curve. Frame-by-frame left ventricular volumes were obtained throughout diastole from single-plane cineangiograms. A volume-time curve with its derivative was generated by computer pro...