tbuckley/cabot-search huggingface dataset:
Effects of H1-receptor stimulation on coronary arterial diameter and coronary hemodynamics in humans.
Authors: KMatsuyama, HYasue, KOkumura, HOgawa, YMorikami, NInotsume, MNakano
Journal: Circulation (1990)

Effects of H1-receptor stimulation on coronary arterial diameter and coronary hemodynamics were examined in 11 patients with angiographically normal coronary arteries and without variant angina or resting angina. Selective H1-receptor stimulation was achieved by infusing histamine into the left coronary artery at a rate of 2.0 micrograms/min for 5 minutes after pretreatment with cimetidine (25 mg/kg). Plasma histamine concentration in the coronary sinus, coronary sinus blood flow, heart rate, and aortic pressure were measured before, during, and after the histamine infusion. Coronary arterial diameter was measured by cinevideodensitometric analysis of coronary arteriograms performed before and immediately after the histamine infusion. During the histamine infusion, plasma histamine concentration in the coronary sinus increased from 0.33 +/- 0.06 to 5.86 +/- 0.71 ng/ml (p less than 0.01); coronary sinus blood flow increased from 98 +/- 12 to 124 +/- 13 ml/min (p less than 0.01), and coronary vascular resis...
Evaluation of combination thrombolytic therapy and timing of cardiac catheterization in acute myocardial infarction. Results of thrombolysis and angioplasty in myocardial infarction--phase 5 randomized trial. TAMI Study Group.
Authors: R MCaliff, E JTopol, R SStack, S GEllis, B SGeorge, D JKereiakes, J KSamaha, S JWorley, J LAnderson, LHarrelson-Woodlief
Journal: Circulation (1991)

Recent trials of myocardial reperfusion using single-agent thrombolytic therapy and sequential cardiac catheterization have supported a conservative approach to the patient with acute myocardial infarction. To evaluate combination thrombolytic therapy and the role of a previously untested strategy for the aggressive use of cardiac catheterization, we performed a multicenter clinical trial with a 3 x 2 factorial design in which 575 patients were randomly allocated to one of three drug regimens--tissue-type plasminogen activator (t-PA) (n = 191), urokinase (n = 190), or both (n = 194) - and one of two catheterization strategies--immediate catheterization with angioplasty for failed thrombolysis (n = 287) or deferred predischarge catheterization on days 5-10 (n = 288). Patients with contraindications to thrombolytic therapy, cardiogenic shock, or age of more than 75 years were excluded. Global left ventricular ejection fraction was well preserved and almost identical at predischarge catheterization (54%), re...
Paget's disease of bone.
Authors: J R Condon
Journal: BMJ (1977)

Two dietary factors have been implicated in the parallel aging of tendons and arteries.Schwartz2 suggests that the trace element silicon is the factor in dietary fibre and hard water which reduces the incidence of CHD.Silicon contributes to the stability of connective tissue by forming -O-Si-O-bridges.Ascorbic acid is the second factor.Its role in collagen synthesis-' makes it essential for both tendons and arteries.Our observations on cardiac patients who take up marathon running show a conspicuous increase in silicon-rich foodstuffs (pectin, bran, and alfalfa) and also ascorbic acid (fresh fruit and vitamin C supplements).The longest run for cardiac patients is the Primo 100-km run on the island of Oahu.It is supported by the cardiac rehabilitation programme of the Honolulu YMCA.The event is social and non-competitive.In our view any dietary manipulation should be aimed at increasing "distance covered on foot.
Toxic Effects of Local Anesthetics
Authors: Daniel C. Moore
Journal: JAMA (1978)

<h3>To the Editor.—</h3> The article "Toxic Effects of Local Anesthetics" by Rudolph H. de Jong, MD (239:1166, 1978), is, as with the majority of the articles and books by Dr de Jong, excellent. However, the implication that diazepam (Valium) should be used prophylactically to prevent systemic toxic reactions in humans, as well as to treat them, is misleading. The studies cited by the author to support this contention were done in laboratory animals and in the research of Dr de Jong with lidocaine (Xylocaine) only. These data have been extrapolated to humans, but the author has no substantial data to support that, in fact, what applies in laboratory animals also applies in humans. To the best of my knowledge, he has not taken this valuable research into a clinical setting to confirm that in humans, diazepam is as effective as in animals, and, furthermore, that the dosage or the time
A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance
Authors: Stanislav Dikiy, Jun Li, Lu Bai, Menglin Jiang, Laura Janke, Xinying Zong, Xiaolei Hao, Beatrice Hoyos, Zhong-Min Wang, Beisi Xu, Yiping Fan, Alexander Y. Rudensky, Yongqiang Feng
Journal: Immunity (2021)
Targeting the mTOR pathway in ovarian cancer.
Authors: A. Pandiella, J. C. Montero, X. Chen, A. Ocana
Journal: Journal of Clinical Oncology (2010)

e15523 Background: Although improvements in the treatment of ovarian cancer have increased the global prognosis, the metastatic disease is still an incurable situation. Therefore, it is necessary to identify druggable pathways and develop new therapeutic strategies against them. The PI3K-Akt-mTOR pathway regulates several biological functions and it is frequently deregulated in human cancer. In ovarian cancer amplification or mutation of PI3KCA or AKT2 oncogenes, which participate in this route, have been described, and may be the cause of mTOR phosphorylation. Methods: We have investigated the components of the mTOR pathway in ovarian cancer cells, and the action of drugs that target this route. For this purpouse we have used biochemical experiments to identify the activation status of different components of the pathway in several ovarian cancer cell lines. For the evaluation of targeted agents MTT studies complemented with cell cycle analysis, apoptosis assays and biochemical experiments were performed. Results: Expression of the proteins of the components of the two mTOR complexes mTORC1 and mTORC2 was variable in distinct ovarian cancer cell lines. The downstream effector of mTORC2, phospho-Akt Serine 473, was activated under resting conditions in most ovarian cancer cell lines. Interestingly, the mTORC1 downstream effector phospho-S6 was active under resting conditions. Due to the frequent activation of mTOR in these cells, we decided to analyze the effect of the dual PI3K and mTOR inhibitor NVP-BEZ235. This drug inhibited the proliferation of ovarian cancer cells in a dose-dependent manner, and did not interfere with the action of other standard of care treatments. Treatment with the drug inhibited mTOR downstream signalling, as evidenced by dephosphorylation of both Akt and S6. Cell cycle analyses showed that NVP-BEZ235 provoked arrest in the G1 phase, and induced up-regulation of p27. Conclusions: These results suggest that mTOR targeting may represent a convenient strategy for the future treatment of ovarian cancer. No significant financial relationships to disclose.
Blacks in the Coronary Artery Surgery Study: risk factors and coronary artery disease.
Authors: CMaynard, L DFisher, E RPassamani, TPullum
Journal: Circulation (1986)

In this paper we examine the relationship between risk factors and angiographically determined coronary artery disease for blacks and whites enrolled in the Coronary Artery Surgery Study (CASS). Analysis of data from the CASS registry indicated that blacks had a higher incidence of hypertension and current cigarette smoking than did whites in CASS and that chest pain was the major reason that both blacks and whites underwent coronary angiography for suspected or proven coronary disease. The CASS data also showed that, despite high levels of risk factors and chest pain, blacks had minimal or absent coronary disease. The results of this study raise several questions. First, to what extent are blacks in CASS representative of blacks in the general population and blacks undergoing coronary angiography? Additionally, are risk factors for coronary artery disease different for blacks than for whites? And finally, how does the physician effectively treat the black patient with high levels of risk factors and mini...
Characterization of acetylcholine-induced membrane hyperpolarization in endothelial cells.
Authors: G FChen, D WCheung
Journal: Circulation Research (1992)

The characteristics of the hyperpolarization response to acetylcholine (ACh) in endothelial cells from the guinea pig coronary artery were studied by microelectrode recording technique. ACh (30 nM to 3 microM) induced membrane hyperpolarization in a dose-dependent manner. The sustenance of the response required the presence of external calcium. The hyperpolarization was not affected by nifedipine (1 microM) but was inhibited by the potassium channel blockers charybdotoxin (10 nM), tetraethylammonium (1 mM), and 4-aminopyridine (0.5 mM). Glibenclamide (10 microM) and apamin (1 microM) were not effective. The inhibitors of endothelium-derived relaxing factor/nitric oxide synthesis N omega-nitro L-arginine (50 microM) and NG-monomethyl L-arginine (30 microM) had no effect on the resting membrane potential or the ACh-induced responses. No hyperpolarization was observed with application of sodium nitroprusside (10 microM) or 8-bromo-cGMP (0.1 microM). Ouabain (10 microM) depolarized the membrane significantly ...
Pyloric Stent Insertion in Malignant Gastric Outlet Obstruction (MGGO): Moving Beyond Palliation
Authors: SM Saeed, S Bilal, MZ Siddique, M Saqib, S Shahid, MA Yusuf
Journal: Endoscopy (2021)

Aims MGOO is seen in advance malignancies. Surgical gastro-jeujenostomy is standard palliative treatment and upfront surgery in resectable gastric cancers. Importance of relieving obstruction in resectable gastric tumours is to have uninterrupted neoadjuvant chemotherapy, which improves overall survival. Our aim is to evaluate efficacy and safety of pyloric stents in gastric outlet obstruction in gastric cancer and to evaluate 1-year survival in patients with resectable obstructing gastric tumours where stents were placed as a bridge to surgery.
Sodium-induced cardiac hypertrophy. Cardiac sympathetic activity versus volume load.
Authors: N GFields, B XYuan, F HLeenen
Journal: Circulation Research (1991)

To investigate the possible contributions of cardiac volume overload and cardiac sympathetic hyperactivity in the effects of sodium on cardiac mass, we evaluated the effects of treatment with saline (1%) and deoxycorticosterone acetate + saline (DOCA/saline) for 10 days and 3 and 6 weeks on ventricular anatomy and intracardiac pressures. Sympathetic activity in the heart and other tissues was assessed at 10 days and 3 weeks by catecholamine turnover rates and tyrosine hydroxylase activity. Both saline and DOCA/saline produced concentric left ventricular (LV) hypertrophy. Right ventricular weight showed only small increases. Saline treatment did not affect LV end-systolic pressure, whereas DOCA/saline caused a moderate increase (to 159 mm Hg). Right atrial pressure was not affected by either treatment, whereas LV end-diastolic pressure increased but only after the development of LV hypertrophy. Both saline and DOCA/saline decreased LV norepinephrine concentration; only DOCA/saline decreased norepinephrine ...
Complications of Urologic Surgery: Prevention and Management
Authors: Navin C. Shah
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neuropeptide Y prevents the blood pressure fall induced by endotoxin in conscious rats with adrenal medullectomy.
Authors: DEvéquoz, BWaeber, J FAubert, J PFlückiger, JNussberger, H RBrunner
Journal: Circulation Research (1988)

Neuropeptide Y (NPY) is a vasoconstrictor peptide known to be present in the adrenal medulla, the terminal nerve endings, and in plasma. This study was designed to test whether NPY could prevent the acute blood pressure fall induced by endotoxin administration. Normotensive rats were subjected to adrenal demedullation on the right side and were either adrenalectomized or sham-operated on the left side. Eight to ten days later, NPY (0.07 microgram/min i.v.) or its vehicle were infused for 95 minutes into these conscious, semirestrained rats. The same experiments were performed with rats that received an infusion of epinephrine (0.1 microgram/min). These doses of NPY and epinephrine when given alone had no blood pressure effect. During the last 75 minutes of the 95-minute infusion, endotoxin (lipopolysaccharide Escherichia coli 0.111:B4, 10 micrograms/min i.v.) or its vehicle were administered. In rats with an intact adrenal gland, endotoxin failed to induce hypotension. In rats lacking a functioning adrena...
Association of asynchronous protodiastolic segmental wall motion with impaired left ventricular relaxation.
Authors: P ALudbrook, J DByrne, A JTiefenbrunn
Journal: Circulation (1981)

To determine if asynchronous segmental relaxation is associated with altered left ventricular (LV) diastolic function, we examined systolic and diastolic wall motion and function indexes in 16 patients without and 16 with asynchronous relaxation (groups 1 and 2, respectively). The segment with asynchronous relaxation was observed most frequently in the free anterior LV wall and was not consistently related geographically to coronary stenosis, nor to systolic asynergy in the same region, but was frequently accompanied by simultaneous segmental inward motion elsewhere in the ventricle. LV chamber volume stiffness during diastolic filling and at end-diastole was statistically similar in each group. Conversely, both T (58.3 +/- 2.3 msec vs 41.0 +/- 3.6 msec) and the isovolumic relaxation period (140.9 +/- 7.5 msec vs 116 +/- 6 msec) were significantly more prolonged, peak negative dP/dt was lower (1314 +/- 57 mm Hg/sec vs 1604 +/- 114 mm Hg/sec), and the y-axis intercept of the diastolic pressure-volume curve...
Epidemiological and Anatomo-Clinical Aspects of Inflammatory Bowel Disease (IBD)
Authors: SD Sanogo, MY Dicko, K Doumbia, G Soumaré, H Sow, MS Tounkara, D Katilé, O Mallé, A Kondé, A Maiga, H Guindo, M Diarra, B Kamaté, A Konaté, B Sanogo, MY Maiga
Journal: Endoscopy (2021)

Aims The aim of our study was to describe the epidemiological and anatomoclinic aspects of chronic inflammatory bowel disease (IBD) in Bamako/MALI
Endocardial catheter mapping in patients in sinus rhythm: relationship to underlying heart disease and ventricular arrhythmias.
Authors: D MCassidy, J AVassallo, J MMiller, D SPoll, A EBuxton, F EMarchlinski, M EJosephson
Journal: Circulation (1986)

Catheter mapping during sinus rhythm was performed in 132 patients with coronary artery disease and 26 patients with congestive noncoronary cardiomyopathy. Each of the patients had a clinical history of one of the following: no ventricular arrhythmia, nonsustained ventricular tachycardia, cardiac arrest, or sustained ventricular tachycardia. The characteristics of the endocardial electrogram and other measured indexes of slow endocardial conduction were compared between patients with different types of disease and in different arrhythmia groups to determine if differences existed. The cardiomyopathic group had a higher percent of normal endocardial electrograms than the coronary artery disease group, with no evidence of slow endocardial conduction. The sustained ventricular tachycardia group exhibited a greater percent of abnormal endocardial electrograms and more evidence of slow endocardial conduction, distinguishing this group from the three other arrhythmia groups. We conclude the following: The under...
Some factors affecting bubble formation with catheter-mediated defibrillator pulses.
Authors: G HBardy, FColtorti, T DIvey, CAlferness, MRackson, KHansen, RStewart, H LGreene
Journal: Circulation (1986)

Factors affecting bubble formation during delivery of defibrillator pulses to arrhythmogenic cardiac tissue via a catheter are unknown. We investigated the role of energy, electrode surface area, interelectrode distance, and electrode polarity on bubble formation and on current and voltage waveforms during delivery of damped sinusoidal discharges from a standard defibrillator to anticoagulated bovine blood. Gas composition was studied with mass spectrometry. Defibrillator energy settings were varied between 5 and 360 J. The principal catheter used for study was a Medtronic 6992A lead. Additional electrodes tested included 2, 5, and 10 mm long No. 6F, 7F, and 8F copper electrodes. Interelectrode distances used to assess the effect of anode-cathode spacing were 1, 5, 10, and 20 cm. Bubble volume increased linearly from 0.043 to 0.134 ml per cathodal pulse and from 0.030 to 3.50 ml per anodal pulse as energy settings were increased from 5 to 360 J (r = .99). Typical smooth waveforms for both current and volt...
Response to: Correcting for cell-type effects in DNA methylation studies: reference-based method outperforms latent variable approaches in empirical studies
Authors: Kevin McGregor, Aurélie Labbe, Celia M. T. Greenwood
Journal: Genome biology (2017)

We thank Hattab and colleagues for their correspondence and their investigation of cell-type mixture correction methods in methyl-CG binding domain sequencing. Here, we speculate on why surrogate variable analysis (SVA) performed differently between their two data sets, and poorly in one of them. Please see related Correspondence article: https://genomebiology.biomedcentral.com/articles/10/1186/s13059-017-1148-8 and related Research article: https://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-0935-y
Long-term changes in mitral valve area after successful mitral commissurotomy.
Authors: J JHeger, L SWann, A EWeyman, J CDillon, HFeigenbaum
Journal: Circulation (1979)

We examined the long-term effects of closed instrumental mitral commissurotomy on mitral valve area (MVA) in 18 patients, followed for as long as 14 years after successful operation. Each patient had preoperative and early postoperative cardiac catheterization; late postoperative determination of MVA was obtained 10-14 years (mean 12.2 years) after commissurotomy. In 17 patients, the MVA was determined by cross-sectional echocardiography and in one patient by repeat cardiac catheterization. Thirteen of 18 patients had no change in MVA between early postoperative study (mean MVA = 2.7 cm2) and late postoperative study (mean MVA = 2.9 CM2). MVA in five patients decreased 0.7-2.2 cm2 (mean 1.4 cm2) during the follow-up period. In these five patients, the mean MVA at early postoperative study was 2.7 cm2 and at late postoperative study was 1.3 cm2 (p less than 0.001). At late postoperative evaluation, cardiac symptoms were associated with severity of mitral stenosis but did not predict restenosis. A successfu...
Thromboxane A2 and prostaglandin endoperoxide receptors in platelets and vascular smooth muscle.
Authors: D LSaussy, D EMais, D RKnapp, P VHalushka
Journal: Circulation (1985)

9,11-Dimethylmethano-11,12-methano-16-(3-iodo-4-hydroxyphenyl)-13, 14-dihydro-13-aza-15 alpha beta-omega-tetranor-TXA2 (I-PTA-OH), a recently synthesized thromboxane (TX) A2/prostaglandin (PG) H2 receptor antagonist, was shown to be a competitive antagonist of human platelet aggregation induced by the stable endoperoxide analog U46619. This antagonism was due to competitive blockade of the platelet TXA2/PGH2 receptor since I-PTA-OH did not antagonize the first phase of ADP-induced aggregation which is TXA2/PGH2 independent, nor did it inhibit TXA2 synthesis. In addition, analysis of dose-response curves to U46619 (0.1 to 40 microM) in the presence of increasing concentrations of I-PTA-OH (0.5 to 10 microM) showed that I-PTA-OH produced a parallel rightward shift of the dose-response curve. Further analysis of the data in the form of a Schild plot yielded a straight line with a slope (m = 1.03) not significantly different from -1. These results are consistent with the notion that I-PTA-OH acts as a competi...
Remarks on the Treatment of Acute Rheumatism by the Tincture of Perchloride of Iron
Authors: J. R. Reynolds
Journal: BMJ (1869)

THE marked effects produced by the tincture of the perchloride of iron on the course of such " spreading" inflammatory affections as erysipelas and diphtheroid sore-throat induced me, some months ago, to admi- nister this medicine to cases of another spreading" inflammatory dis- case-viz., acute rheumatism.I have treated eight cases by this drug- cases all of them severe, and, with one exception, occurring during the unfavourable weather of the spring of this year.The number of cases is too small for a general conclusion to be drawn from them as to the treatment of rheumatic fever; but the character of the facts is such that
Ventriculoatrial Shunt for Hydrocephalus
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal