tbuckley/cabot-search huggingface dataset:
Abstract P186: Plasma Ceramides Are Associated With HIV Treatment and Increased Risk of Carotid Artery Plaque in Two Prospective HIV Cohorts
Authors: Wei Zhao, Simin Hua, Clary B Clish, Amy Deik, David B Hanna, Sabina A Haberlen, Sanjiv J Shah, Wendy S Post, Howard N Hodis, Alan L Landay, Kathryn Anastos, Robert C Kaplan, Qibin Qi
Journal: Circulation (2018)

Introduction: Ceramides, a family of bioactive sphingolipids on plasma membrane, have been implicated in inflammation, immune response, and HIV infection. Recent studies have related plasma ceramides with cardiovascular diseases (CVD), but data are sparse in HIV infected people who have excess CVD risk. Methods: We profiled baseline plasma ceramides C16:0, C22:0, C24:0 and C24:1 in 737 participants aged 35-55 years (520 HIV+, 217 HIV-) from two prospective cohorts (Women’s Interagency HIV Study and Multicenter AIDS Cohort Study) and examined their associations with the risk of incident carotid artery plaque (CAP), assessed by B-mode carotid artery ultrasound imaging over a 7-year period. Plasma levels of ceramides were inverse-normal transformed. We used robust variance estimates from Poisson regression to estimate risk ratios (RRs) on CAP per standard deviation increment in ceramides. We also compared ceramide levels by HIV infection status and antiretroviral therapy (ART) use. Results: Over a 7-year follow-up, 112 individuals developed CAP (90 HIV+, 22 HIV-). After multivariate adjustment, ceramides C16:0 (RR=1.40 [95% CI: 1.09-1.79]; P &lt;0.001) and C24:1 (RR=1.32 [1.06-1.65]; P &lt;0.001), but not ceramides C22:0 or C24:0, were significantly associated with increased risk of CAP in all participants. Ceramides C16:0 showed stronger association with CAP in HIV+ people compared to HIV- people ( Figure ), but there was no significant effect modification by HIV infection status ( P for interaction&gt;0.05). Compared to HIV- group, plasma ceramides C16:0, C22:0 and C24:1 were significantly ( P &lt;0.001) higher in HIV+ group. Further analyses in HIV+ group showed that ceramides were significantly ( P &lt; 0.001) higher in people using ART than those not using ART. Conclusions: This study reported that elevated plasma ceramides, especially C16:0, are increased with ART use and associated with HIV-related atherosclerosis. Our data suggest that ceramides might be an intermediate link between HIV infection and CVD risk.
INDEX TO ADVERTISERS
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ACE inhibition, AT1- and ETA-receptor antagonism: Comparison of structural reorganization of the myocardium after infarct in stroke prone spontaneoully hypertensive rats Alexander Reinecke, Quin ui Xia, Marc Dorenkamp, Susanne Pens, Christian Sttotz. Harro Bitterling, R�diger W. R. Simon and Thomas Unger. Clinic of Cardiology, University of Kiel, Kiel, Germany, Institute of pharmacology, University of Kiel, Kiel, Germany
Journal: Journal of the American College of Cardiology (2001)
Gender and racial differences in clinical outcome after percutaneous coronary interventions George Dangas, Roxana Mehran, Alexandra J. Lansky, Dmitriy Feldman, David J. D'Agate, Lowell F. Satler, Kenneth M. Kent, Augusto D. Pichard, Luis Gruberg, Javed M. Ahmed, Gregg W. Stone, Martin B. Leon. Cardiovascular Research Foundation, New York, Washington Hospital Center, Washington, DC
Journal: Journal of the American College of Cardiology (2001)
Thomas Beddoes or, medicine and social conscience
Authors: J. Barzun
Journal: JAMA (1972)

In a remarkable piece of scholarly detection<i>In Search of Swift</i>, Mr. Denis Johnston refers to an opinion expressed in 1807 by "a certain Dr. Beddoes." As an historian of letters Mr. Johnston might have suspected that he was speaking of the father of Thomas Lovell Beddoes, the poet. Had he done so, he might have found that the subject of his dismissive phrase was also the great-grandfather of Gerard Manley Hopkins, another poet; and perhaps our critic might have gone on to catch a glimpse of a remarkable figure in the history of science and medicine. But it must be admitted that the elder Beddoes is not easy to get at. His works are in few libraries.<i>The Dictionary of National Biography</i>is cool about him, and the recent<i>Dictionary of Scientific Biography</i>, though more sympathetic, adopts the dying Beddoes' own view that he had wasted his talents by
Error in Discussion
Journal: JAMA Neurology (2021)

Amber Salter, PhD; Robert J. Fox, MD; Scott D. Newsome, DO; June Halper, MSCN; David K. B. Li, MD; Pamela Kanellis, PhD; Kathleen Costello, MSCN; Bruce Bebo, PhD; Kottil Rammohan, MD; Gary R. Cutter, PhD; Anne H. Cross, MD
Television and Violence
Authors: Brandon S. Centerwall
Journal: JAMA (1992)

IN 1975, Rothenberg's Special Communication in<i>JAMA</i>, "Effect of Television Violence on Children and Youth," first alerted the medical community to the deforming effects the viewing of television violence has on normal child development, increasing levels of physical aggressiveness and violence.<sup>1</sup>In response to physicians' concerns sparked by Rothenberg's communication, the 1976 American Medical Association (AMA) House of Delegates passed Resolution 38: "The House declares TV violence threatens the health and welfare of young Americans, commits itself to remedial actions with interested parties, and encourages opposition to TV programs containing violence and to their sponsors."<sup>2</sup> Other professional organizations have since come to a similar conclusion, including the American Academy of Pediatrics and the American Psychological Association.<sup>3</sup>In light of recent research findings, in 1990 the American Academy of Pediatrics issued a policy statement: "Pediatricians should advise parents to limit their children's television viewing to 1 to 2
Public health must be a priority in the 2020 US election
Authors: None The Lancet Public Health
Journal: The Lancet Public Health (2020)

As the November, 2020, US presidential election approaches, applying a public health lens should be a decisive factor in the minds of American voters. The upcoming election plays out against the backdrop of the COVID-19 pandemic, a public health emergency that is exposing entrenched inequalities. For the next US Administration, the challenge ahead is considerable, but with its unique resources and potential, there could be an opportunity for the country to put the right to health, health equity, and social justice at its core.
Abstract 17192: ALDH1A3 Induces NFY to Coordinate Transcription of Cell Cycle and Metabolic Genes Necessary for Smooth Muscle Proliferation in Pulmonary Hypertension
Authors: Dan Li, Ningyi Shao, Kevin Contrepois, Shalina Taylor, Shoichiro Otsuki, Lingli Wang, Marlene Rabinovitch
Journal: Circulation (2018)

Background: In developing disease modifying therapies for pulmonary arterial hypertension (PAH), it is important to understand the molecular basis for hyperproliferation of pulmonary arterial smooth muscle cells (PASMC) that progressively occlude the vessel lumen. Previously we presented studies using H3K27 ChIP Seq and RNA Seq in PAH vs. control PASMC, and showed that an increase in ALDH1A3 is responsible for both heightened proliferation and H3K27ac enhancer marks in cell cycle and metabolic enzyme genes. Methods and Results: We now present molecular and metabolic studies and experiments in transgenic mice that delineate the mechanism by which ALDH1A3 plays a critical role in PAH PASMC proliferation. Promoter binding motif analysis of sites that are ALDH1A3 dependent in PAH PA SMC identified NFY family members as putative transcription factors. We confirmed their role in increasing three energy producing metabolic enzymes PKM2, DLD and IDH1 and two cell cycle genes, CCNA2 and CDC20. We verified that their mRNA transcripts and protein levels are elevated in PAH PASMC and dependent on increased ALDH1A3 and NFY(n=3, p&lt;0.05) The accumulation of acetyl-CoA is increased in PAH PASMC with siControl vs. siALDH1A3. The nuclear localization of increased PAH PASMC ALDH1A3 indicates that generation of acetyl CoA from acetylaldehde could acetylate histones at H3K27 target sites marked by NFY binding. From non-targeted metabolomic analyses by LC/MS, we found ALDH1A3 dependent metabolites in the glycolytic and pentose phosphate pathways in PAH PASMC, consistent with the functions of PKM2, DLD and IDH1. We then showed that ALDH1A3 is induced by hypoxia, and required for SMC proliferation and pulmonary hypertension in mice exposed to three weeks of chronic hypoxia (10% oxygen). Gender matched transgenic mice with SMC deletion of Aldh1a3 had reduced pulmonary hypertension when compared to littermate controls, assessed by right ventricular systolic pressure (n=8, p&lt;0.05). Conclusions: Our studies reveal an ALDH1A3-dependent coordination of histone acetylation at NFY transcription factor binding sites of key metabolic enzyme and cell cycle genes in highly proliferative PAH PASMC from PAH patients, that is critical in the development of pulmonary hypertension.
Correction to Collaborator’s Name
Journal: JAMA Neurology (2020)

Ian Miller, MD; Ingrid E. Scheffer, MBBS, PhD, FRS; Boudewijn Gunning, MD; Rocio Sanchez-Carpintero, MD, PhD; Antonio Gil-Nagel, MD, PhD; M. Scott Perry, MD; Russell P. Saneto, DO, PhD; Daniel Checketts, MSc; Eduardo Dunayevich, MD; Volker Knappertz, MD; for the GWPCARE2 Study Group
Geneticists ponder ethical implications of screening
Authors: B. Merz
Journal: JAMA (1985)

"This is a fictitious but not an unrealistic scenario. And I think it could be applied to a lot of people at risk for autosomal dominant disorders that may soon be identified by [DNA diagnostic tests]," says Philip Rilley, MD, JD, who spoke at the recent annual meeting of the American Society for Human Genetics in Salt Lake City, Rilley, staff internist at the Eunice Kennedy Shriver Institute in Boston and a practicing attorney, was one of several speakers at a symposium on the ethical implications of the new genetics. At the symposium geneticists, facing the imminent availability of DNA diagnostic tests for a host of inherited disorders (see accompanying article), mulled over the tests' potential uses and abuses in prenatal counselling. They also explored the advantages and disadvantages of genetic screening for adults who may have inherited disorders for which there is no effective therapy. Participants agreed that there
Error in Figure and Table
Authors: Stephanie Doupnik, Cadence Bowden, Steven Marcus
Journal: JAMA Psychiatry (2020)

Christa Lese Martin, PhD; Karen E. Wain, MS; Matthew T. Oetjens, PhD; Kasia Tolwinski, PhD; Emily Palen, MS; Abby Hare-Harris, PhD; Lukas Habegger, PhD, MS; Evan K. Maxwell, PhD, MS; Jeffrey G. Reid, PhD; Lauren Kasparson Walsh, MS; Scott M. Myers, MD; David H. Ledbetter, PhD
Colontown University: Patient-created disease education.
Authors: Nancy Seybold, Manju George
Journal: Journal of Clinical Oncology (2022)

205 Background: PALTOWN’s Facebook community, COLONTOWN, serves over 6,000 colorectal cancer (CRC) patients and caregivers. 81% of members are late stage patients (or late stage caregivers), and 85% are under the age of 60. They are highly motivated to find reliable information about treatment options as quickly as possible. Many arrive with little prior CRC education. Here we illustrate the creation of a patient-centric disease education program, COLONTOWN University (CTU), developed from the conversations and information journeys in COLONTOWN. Methods: CTU is a unique model for disseminating patient-facing disease education. CTU’s patient and caregiver staff develop original resources from a patient perspective, and work with principal investigators, testing companies, and other partners to create content specifically designed for the Learning Centers. Each Center provides resources to address the information needs of patients across both the spectrum of disease education and of CRC disease experience. Within the University’s online platform, self-contained Learning Centers offer structured resource libraries on topics of high interest to patients. Results: CTU creates patient-centric disease education that is accessible and more sophisticated than typical patient education materials. The discussions in COLONTOWN, in groups focused on specific biomarkers, metastases locations, and treatment modalities, provide members with the framework for understanding their disease. CTU gives them the resources they need to have informed discussions with their care teams. The CTU platform provides insight into what resources are most utilized. Survey tools facilitate an understanding of whether patients feel they have access to more treatment options, and have more productive interactions with their care teams, as a result of the education provided by CTU and the conversations with their peers in COLONTOWN. Conclusions: In its first year, CTU has become the education resource of choice for the thousands of members of COLONTOWN. Clinicians, principal investigators, and industry have all been enthusiastic partners in the development of resources. The positive response to CTU demonstrates the value of this model of patient-driven disease education.[Table: see text]
Gilead Buys into Tizona's Anti–HLA-G Strategy
Journal: Cancer Discovery (2020)

Abstract Gilead announced plans in July to pay $300 million for a 49.9% stake in Tizona Therapeutics, with the option to buy the rest of the company for $1.25 billion. Whether Gilead follows through with the acquisition will hinge on how well Tizona's investigational HLA-G inhibitor, TTX-080, fares in early-stage clinical trials.
Books Received
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Parametric imaging for visualisation of replenishment kinetics following ultrasound induced destruction of contrast microbubbles: In vitro validation studies and first results in humans Klaus Tiemann, Alexander Ehlgen, J�rg K�ster, Christoph Pohl, Thomas Schlosser, Christian Veltmann, Stefan Lohmaier, Stefanie Kuntz-Hehner, Berndt L�deritz, Harald Becher. Dept. of Cardiology, Bonn, Germany
Journal: Journal of the American College of Cardiology (2001)
Cladribine Combined with Idarubicin and High-Dose AraC (CLIA2) As a Frontline and Salvage Treatment for Young Patients (≤65 yrs) with Acute Myeloid Leukemia
Authors: Mansour Alfayez, Hagop M. Kantarjian, Farhad Ravandi, Guillermo Garcia-Manero, Marina Y. Konopleva, Naval G. Daver, Courtney D. DiNardo, Gautam Borthakur, Prithviraj Bose, Michael Andreeff, Yesid Alvarado, Musa E. Yilmaz, Naveen Pemmaraju, Steven M. Kornblau, Zeev E. Estrov, Christopher B. Benton, Koichi Takahashi, Kiran Naqvi, Rebecca Slack, Rubiul Islam, Elias J. Jabbour, Jorge E. Cortes, Tapan M. Kadia
Journal: Blood (2018)
与 COVID‐19 相关的皮肤疾病以及相关生物制剂
Journal: British Journal of Dermatology (2021)

例(3Á2%)确诊 为 COVID-19 阳性, 227 例(3Á0%)经确认为 COVID-19 阳性死亡患者。 在 COVID-19 阳性组中未观察到特定皮肤疾病或生物制剂暴露的显著增加。皮肤疾病的存在和生物制剂暴露似乎也没有 影响临床结果 (COVID-19 感染的严重程度) 或死亡率 (死于 COVID-19 的可能性) 。
<i>Notes from the Field:</i> Three Human Rabies Deaths Attributed to Bat Exposures — United States, August 2021
Authors: Amber Kunkel, Faisal S. Minhaj, Florence Whitehill, Connie Austin, Christine Hahn, Amanda J. Kieffer, Leila Mendez, Jael Miller, Leslie A. Tengelsen, Crystal M. Gigante, Lillian A. Orciari, Agam K. Rao, Ryan M. Wallace
Journal: MMWR Morbidity and Mortality Weekly Report (2022)
Prevalence of information needs among emerging and young adult colorectal cancer survivors.
Authors: Serena Yi, Karli Rodriguez, Julia Stal, Sally Cohen-Cutler, Phuong Gallagher, Afsaneh Barzi, David R. Freyer, Joel Milam, Heinz-Josef Lenz, Kimberly Ann Miller
Journal: Journal of Clinical Oncology (2022)

71 Background: The information needs of young adult (YA) cancer survivors have been described, however, the specific needs of YA colorectal cancer (CRC) survivors are not well-documented. Characterizing the distinct unmet needs of YA CRC survivors is important given their unique cancer experience which may include an ostomy, chronic bowel symptoms, and functional deficits. The purpose of this study was to examine CRC survivors’ unmet needs across general, clinical, and psychosocial domains. Methods: An online, cross-sectional survey was administered via Facebook in collaboration with a national YA CRC patient advocacy organization. Respondents (diagnosed 18-39) endorsed areas in which they required more information on aspects of their lives that may have been affected by their cancer experience. Needs were stratified by life stage (emerging [18-29 years] and young [30-39] adulthood). Results: Respondents (n=189) were colon (40.2%) and rectal (59.8%) cancer survivors with a mean current age of 32.2 years (SD=4.6) and a mean age of 30.2 years (SD=4.3) at diagnosis. Most endorsed items per domain included: nutrition and diet (52.1%), complementary and alternative treatments (45.4%), and talking about your cancer experience with family, friends, and co-workers (36.1%). Survivors in emerging adulthood (n=80), compared with those in young adulthood (n=109), endorsed notably greater needs in: staying physically fit (57.5% versus 38.5%), complementary and alternative treatments (57.5% versus 36.7%), and advice/help about dating and intimate relationships (18.8% versus 6.4%). Conclusions: Overall, half of respondents endorsed a desire for information on nutrition and diet, staying physically fit, and complementary and alternative treatments. Differing endorsement rates by age group indicate the importance of tailored approaches. Optimal counseling, resources, and referrals specific to life stage can mitigate the unmet needs of YA CRC survivors to improve health outcomes and quality of life.[Table: see text]
REPORT ON MASSAGE.
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 333: MED13-dependent Regulation of Cardiac Thyroid Hormone Signaling
Authors: Rachel Minerath, Ines Martins, Chad Grueter
Journal: Circulation Research (2017)

Thyroid hormone (TH) is a key regulator of cardiac metabolism. While hypothyroidism is known to result in adverse cardiac effects, the molecular mechanisms that modulate TH signaling are not completely understood. Mediator is a multiprotein complex that coordinates signal dependent transcription factors with basal transcriptional machinery. Mediator complex protein, MED13, was previously demonstrated to repress numerous thyroid receptor (TR) response genes in the heart. Furthermore, we have previously demonstrated that mice overexpressing cardiac MED13 (MED13cTg) treated with propylthiouracil (PTU), an inhibitor of T3 biosynthesis, were resistant to PTU-dependent decreases in cardiac contractility. Here we demonstrate that MED13 expression is induced in the hearts of mice in response to a PTU diet. To elucidate the role of MED13 in transcriptional regulation of cardiac TH signaling, cardiac-specific Med13 knockout mice (MED13cKO) and control mice were placed on a PTU diet or normal chow diet for 4 weeks. An additional group of mice on PTU diet were treated acutely with thyroid hormone (T3). While heart weight to body weight ratios did not differ between genotypes, RNA sequencing was performed from hearts of these mice to understand the role of MED13 in TR-dependent transcription. Echocardiography was performed to assess cardiac function in these mice. In addition, histology was performed to evaluate cardiac structure and fibrosis. These studies demonstrate that MED13 is induced in response to hypothyroidism and further deciphers molecular mechanisms of MED13 regulation of TR-dependent transcription.