tbuckley/cabot-search huggingface dataset:
Ambidexterity
Authors: J. Sawyer
Journal: BMJ (1900)

AMBIDEXTERITY. [Nov.3, I0 of treatment that is available.Moreover, in a variety of ways it may minister indirectly to recovery; namely, by the relief of pain and sleeplessness; by the-stimulation of depressed activity; by soothing over-excitement; by supplying materials of which the body is in need, such as lime, iron, or fat; by promoting elimination through the skin, bowels, or kidneys;and by efforts to obviate the tendency to death.Surely this bare enumeration is sufficient to redeem the sphere of
Miscellanea Medica
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Management of rheumatoid arthritis in China: a study of the implementation of 2019 EULAR recommendations
Authors: Shangyi Jin, Nan Jiang, Yuehong Huo, Xinwang Duan, Yongfei Fang, Cheng Zhao, Hongbin Li, Min Yang, Zhirao Huang, Pingting Yang, Hongfeng Zhang, Feng Zhan, Youlian Wang, Yanhong Wang, Chanyuan Wu, Qian Wang, Evelyn Hsieh, Mengtao Li, Xinping Tian, Yan Zhao, Xiaofeng Zeng
Journal: Annals of the Rheumatic Diseases (2022)
"TREATMENT OF PYELITIS IN INFANCY AND CHILDHOOD"
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
To Occlude or Not to Occlude the Left Atrial Appendage in Women
Authors: Tania Ahuja, Nicholas J. Kiefer, Arun Manmadhan
Journal: JAMA Cardiology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Is schizophrenia a neurodevelopmental disorder?
Authors: R M Murray, S W Lewis
Journal: BMJ (1987)

<h3>Abstract</h3> We have investigated the flow and desiccation-driven self-assembly of <i>Klebsiella Pneumoniae</i> in the naturally evaporating sessile droplets. <i>Klebsiella Pneumoniae</i> exhibits extensive changes in its morphology and forms unique patterns as the droplet dries, revealing hitherto unexplored rich physics governing its survival and infection strategies. Self-assembly of bacteria at the droplet contact line is characterized by order-to-disorder packing transitions with high packing densities and excessive deformations (bacteria deforms nearly twice its original length scales). In contrast, thin-film instability-led hole formation at the center of the droplet engenders spatial packing of bacteria analogous to honeycomb weathering. The varying physical forces acting on bacteria based on their respective spatial location inside the droplet cause an assorted magnitude of physical stress. Self-assembly favors the bacteria at the rim of the droplet, leading to enhanced viability and pathogenesis on the famously known “coffee ring” of the droplet compared to the bacteria present at the center of the droplet residue. Mechanistic insights gained via our study can have far-reaching implications for bacterial infection through droplets, e.g., through open wounds.
Constrictive pericarditis.
Authors: R. A. Sutton
Journal: BMJ (1968)

BRITIsHrehabilitation situation that the more severely incapacitated are treated alongside the less handicapped, as this not only constitutes a stimulus to the patients but also to the staff engaged in this work.This review of the present situation is un- doubtedly timely, and one must hope sincerely that the obvious points emerging from it will neither be ignored nor be given the implica- tion that a rash of rehabilitation centres is required.Such rapid expansion is neither economically possible nor entirely desirable.The growth of rehabilitation requires to be carefully planned not only on a regional basis but as part of a carefully designed national policy.
SI units.
Authors: B H Bass
Journal: BMJ (1975)

aged 24-50) were then visited without prior waring and their height and weight -easured.Their report heights and weights were on average 05 in (12-7 n) above and 6-1 lb (3'13 kg) below their actual measurements.As in Ashwell and Etchell's paper, overweight was assessed using the Metrpolitan Life Insurance Company tables.2For 90% of the women the reported measurements indicated a lower degree of overwetght than the actual measurements, the difference being roughly proportional to the degree of overweight.As well as broadly dassifying body size as either "overweight," "saitable," or "underweight" Ashwell and Etchell define categories of over-and underweight.In- dividuals 30%, 20%, and 10% above ideal weight were classed as severely, moderately, and mildly overweight respectively, with corresonding groupings for underweight.UJing these categories 15 of the 40 women in our study were classified in a lower category on reported ithan on actual meaurements.Four of these changes were fron the broad classification "overweight" to that of "suitable weight"Our data indicate that reported height and weight should be treated with great caution, as there appears to be systematic underestimation of body size.It may well be that this underestimation of body size as assessed from reported data reflects aware- ness of overweight status.We would sug- gest that any fturther studies on perception of overweight should obtain information on reported as well as actual height and weight and also perceived weight status.-Weare, etc.,
The effect of a third-dose BNT162b2 vaccine on anti-SARS-CoV-2 antibody levels in immunosuppressed patients
Authors: Esther Saiag, Ayelet Grupper, Irit Avivi, Ori Elkayam, Ron Ram, Yair Herishanu, Yael Cohen, Chava Perry, Victoria Furer, Helena Katchman, Liane Rabinowich, Merav Ben-Yehoyada, Tami Halperin, Roni Baruch, Hanoch Goldshmidt, David Hagin, Ronen Ben-Ami, Eli Sprecher, David Bomze
Journal: Clinical Microbiology and Infection (2022)
Phenacetin nephropathy.
Authors: J. A. Abel, R. A. Miley
Journal: BMJ (1970)

importance of having a manometer or release valve incorporated in the circuit has been stressed.Seed, Shakespeare, and Mul- doon' stated that the inflow pressure should not rise above 20 mm.Hg, a higher pressure usually indicating a blocked cannula.One of their patients suffered from tachycardia and a fall in blood pressure when the insufflation pressure rose above 40mm.Hg for a short time, but recovery occurred immediately on decompression.These authors attributed the hypotension to compression of the vena cava, and suggested that-it was more likely to occur earlier with a tense abdominal wall than with flaccid musculature.Splinting of the diaphragm will also embarrass respiration, and regurgitation of stomach contents may occur.Once the dangers of overdistension are realized they can be easily avoided, but should this occur immediate release of pres- sure and raising the legs should quickly restore normal cardiac and respiratory function.-Iam, etc., HUMPHREY ARTHURE.
British Medical Journal, London
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NIMG-50. VOLUMETRIC ANALYSIS OF IDH-MUTANT LOW-GRADE GLIOMA: A NATURAL HISTORY STUDY OF TUMOR GROWTH RATES BEFORE AND AFTER TREATMENT
Authors: Ray Huang, Robert J Young, Benjamin Ellingson, Harini Veeraraghavan, Wei Wang, Tracy Luks, John Kim, Elizabeth Gerstner, David Schiff, Katherine B Peters, Ingo K Mellinghoff, Susan Chang, Timothy Cloughesy, Patrick Y Wen
Journal: Neuro-Oncology (2017)

Low-grade gliomas, particularly those carrying IDH1/2 mutations, often demonstrate long survival times making evaluation of treatment efficacy difficult. We investigated the volumetric growth rate of IDH mutant gliomas to determine whether a significant change in growth rate before and after treatment can be detected, thereby establishing this imaging approach as a response endpoint in low-grade glioma trials. In this multicenter study, 241 adult patients who had progressive nonenhancing gliomas (WHO grade II or III) with IDH1 or IDH2 mutation were retrospectively identified. Subjects were required to have at least 3 MRI scans containing T2/FLAIR imaging spanning a minimum of 6 months prior to treatment. A subset of 100 patients who received chemotherapy, radiation therapy, or chemoradiation therapy and had more than 2 post-treatment imaging time points available were evaluated for change in pre- and post-treatment growth rates. Semi-automatic segmentation was performed to calculate tumor volume at each time point. A mixed-effects model was used to study tumor growth prior to treatment. A piecewise mixed model was used to compare tumor growth rates pre- and post-treatment. Under an exponential tumor growth model assumption, the pre-treatment volumetric growth rate for the entire cohort (N=241) was 0.196 mL/180days (95%CI:[0.168-0.224]) when measured by all available MR scans and 0.296 mL/180days (95%CI:[0.252-0.340]) when measured using scans within one year of treatment initiation. Using MRI measurements within one year before and one year after treatment initiation (N=100), there was a significant difference in volumetric growth rates before (0.276 mL/180days, 95%CI:[0.194-0.358]) and after treatment (-0.156 mL/180days, 95%CI:[-0.241, -0.071]) (p<0.0001). In this study, we evaluated the growth rates of IDH mutant gliomas to establish the natural history of tumor growth behavior and provide preliminary evidence that changes in tumor volume growth rates can be a meaningful endpoint of treatment response.
Blood biomarkers and association with clinical outcomes in metastatic castration-resistant prostate cancer (mCRPC): prespecified longitudinal analysis from the ACIS study of apalutamide (APA) or placebo combined with abiraterone acetate plus prednisone (AAP).
Authors: Eleni Efstathiou, Gerhardt Attard, Justin Lucas, Shibu Thomas, Michael Gormley, Clemente Aguilar-Bonavides, Thomas W. Flaig, Fabio Franke, Oscar B. Goodman, Stephane Oudard, Christopher Michael Pieczonka, Susan Li, Shiva Dibaj, Sabine D. Brookman-May, Kesav Yeruva, Sharon Anne McCarthy, Thomas Steuber, Hiroyoshi Suzuki, Dana E. Rathkopf, Fred Saad
Journal: Journal of Clinical Oncology (2022)

142 Background: In ACIS, APA + AAP improved radiographic progression-free survival in mCRPC vs AAP; difference in overall survival (OS) was not statistically significant. We report a prespecified analysis of androgen receptor (AR) or non-AR genomic/transcriptional aberrations, known to be associated with poor prognosis, and their associations with OS in patients (pts) with mCRPC. Methods: Circulating tumor (ct)DNA and aberrations in 17 PC-relevant genes were assessed using next-generation sequencing at baseline (BL; n = 197) and at end of study treatment (EOST; n = 140) (biomarker population). ctDNA was summarized qualitatively; genomic aberrations were normalized by ctDNA detection. AR splice variant version 7 (ARv7) was detected by quantitative RT-PCR. Cox proportional hazards model assessed association of OS with biomarkers in univariate/multivariate analyses overall and in pts receiving subsequent treatment (tx). Results: BL characteristics of biomarker and total study populations were similar. From BL to EOST: ctDNA detection did not differ (123/196 [63%] to 92/140 [66%], p=0.6); significant increases occurred in ARv7, AR mutations, and any AR aberration (Table). Prevalence of aberrations in PI3K and homologous recombination repair (HRR) pathways did not change from BL to EOST (40/123 [33%] to 34/92 [37%], p=0.5 and 18/123 [15%] to 14/92 [15%], p&gt;0.9, respectively). Worse OS was associated with ctDNA detection or HRR pathway inactivation at BL (HR, 2.5 or 2.2; all p &lt; 0.001) or presence of ctDNA, ARv7, AR amplification or inactivation of TP53, RB1, or RB1/TP35 pathway at EOST (2.2, p &lt; 0.001; 2.1, p &lt; 0.001; 2.6, p &lt; 0.001; 1.5, p &lt; 0.05; 1.7, p &lt; 0.05; 2.1, p &lt; 0.001, respectively) in univariate analyses. EOST ARv7, AR amplification, and inactivation of RB1, TP53, or RB1/TP53 pathway was associated with worse OS in pts receiving subsequent tx. Detection of ctDNA and RB1 inactivation at BL and RB1/TP53 pathway inactivation at EOST was strongly associated with worse OS (2.1, 3.3, 2.9, respectively, all p &lt; 0.01) in multivariate analyses. Conclusions: In ACIS, AAP or APA + AAP tx was associated with increased AR mutations and ARv7 expression. Detection of ctDNA and select AR/non-AR aberrations may predict poor survival in mCRPC. These markers may be used to improve tx selection following confirmation of their predictive value. Clinical trial information: NCT02257736. [Table: see text]
Travel to Meet a Need
Authors: J. R. E.
Journal: Annals of Internal Medicine (1962)

Editorials1 February 1962Travel to Meet a NeedJ. R. E.J. R. E.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-2-357 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSometimes unusual opportunities arise to provide for the physician's need to travel. Such an opportunity is announced in this issue on page lxi ofMedical Newsunder the title,The Peace Corps: A Challenge to Physicians. Physicians are needed by the Peace Corps to serve in the underdeveloped countries of the world. The gap between the standards of living of the rich and poor nations is one of the great problems of this generation. The Peace Corps is a constructive effort on the part of our country to meet "the rising tide of expectation" of underprivileged peoples to share the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1962Volume 56, Issue 2Page: 357-357KeywordsMotivation ePublished: 1 December 2008 Issue Published: 1 February 1962 PDF downloadLoading ...
Postoperative pain.
Authors: F H Creed
Journal: BMJ (1980)

What the fetus feels SIR,-I welcomed Dr H B Valman's excellent summary of early fetal awareness (26 January, p 233).In addition to simple sensory modalities, I am sure that the fetus responds to admixtures of complex sensations and of those hormones that derive from mother-for example, in singing, dancing, and vomiting.When a mother undergoes ultrasound scann- ing of the fetus, this seems a great opportunity for her to meet her child socially and in this way, one hopes, to view him as a companion aboard rather than as a parasite responsible for the symptoms of pregnancy.Doctors and technicians scanning mothers have a great opportunity to enable mothers to form an early affectionate bond to their child by demonstrating the child to the mother.This should help mothers to behave concernedly towards the fetus throughout pregnancy and may be expected to increase the bond on childbirth.
A physician's guide to adoption
Authors: N. K. O'Connor
Journal: JAMA (1988)

<h3>To the Editor.</h3> —The article entitled "A Physician's Guide to Adoption"1 in the Dec 25, 1987, issue of<i>JAMA</i>ignores many aspects of adoption. Although there were good discussions of infertile childless couples adopting babies and toddlers and of black couples adopting black children, there was no mention of other types of adoptive parents or children. For example, there was no discussion of adoption by Hispanics or Native Americans, which was surprising in view of the fact that two of the authors live in areas with large Hispanic populations. Single-parent adoption, which is not uncommon, was not addressed. There was no attention given to families with children (by adoption or by birth) who decide to expand their families through adoption or to foster families who adopt the children they care for. There was no mention of men who adopt. This is especially important because the most common type of adoption
Metabolic alkalosis
Authors: F. L. Coe
Journal: JAMA (1977)

METABOLIC ALKALOSIS, a primary increase in the alkali content of the blood, is commonly seen in hospital practice. Increase in blood pH reduces ionized calcium concentration and can lead to tetany. The irritability of the CNS increases and convulsive tendencies are aggravated. Respiration can be depressed. Electrocardiographic changes resemble those of hypokalemia. Especially in patients receiving digitalis, or when there already exists serious systemic disease, alkalosis may be a potentially serious hazard.<sup>1</sup> <h3>DEFINITION OF METABOLIC ALKALOSIS</h3> As the Pco<sub>2</sub>of blood rises above the normal value of 40 mm Hg, blood pH falls (so-called respiratory acidosis). Progressive reduction of Pco<sub>2</sub>, below normal, leads to elevated blood pH (respiratory alkalosis). The actual confidence band relating pH to Pco<sub>2</sub>of arterial blood has been experimentally determined.<sup>2</sup>Metabolic alkalosis is defined by a blood pH above that predicted for the prevailing Pco<sub>2</sub>, for only removal of excessive
Measles immunization.
Authors: R. E. Smith
Journal: BMJ (1968)

BRITIsHrehabilitation situation that the more severely incapacitated are treated alongside the less handicapped, as this not only constitutes a stimulus to the patients but also to the staff engaged in this work.This review of the present situation is un- doubtedly timely, and one must hope sincerely that the obvious points emerging from it will neither be ignored nor be given the implica- tion that a rash of rehabilitation centres is required.Such rapid expansion is neither economically possible nor entirely desirable.The growth of rehabilitation requires to be carefully planned not only on a regional basis but as part of a carefully designed national policy.
A DANGER IN ORGANOTHERAPY.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal