tbuckley/cabot-search huggingface dataset:
Inflammatory and Biomechanical Drivers of Endothelial-Interstitial Interactions in Calcific Aortic Valve Disease
Authors: Katherine Driscoll, Alexander D. Cruz, Jonathan T. Butcher
Journal: Circulation Research (2021)

Calcific aortic valve disease is dramatically increasing in global burden, yet no therapy exists outside of prosthetic replacement. The increasing proportion of younger and more active patients mandates alternative therapies. Studies suggest a window of opportunity for biologically based diagnostics and therapeutics to alleviate or delay calcific aortic valve disease progression. Advancement, however, has been hampered by limited understanding of the complex mechanisms driving calcific aortic valve disease initiation and progression towards clinically relevant interventions.
Abstract 448: Protective Role of Crataegus Oxycantha in Myocardial Ischemia/Reperfusion Injury by Activating Angiogenesis
Authors: Divya Dasagrandhi, Anusuyadevi Muthuswamy, Jayachandran Kesavan Swaminathan
Journal: Circulation Research (2017)

Rationale: Resuscitation of infarcted myocardium during ischemia/ reperfusion (I/R) injury is challenging process due to intrinsic complex mechanism. Reperfusion or revascularization is the best therapy to limit amount of infarction. Objectives: The current study was to explore the protective role of ethanolic extract of Crataegus oxycantha (COC) in myocardial I/R injury and to find its effect on angiogenesis. Methods and Results: Male guinea pigs were randomized into four groups control (con; n=6), high fat diet (hfd; n=6), high fat diet + drug (hfd+coc; n=6) and drug (coc; n=6). Myocardial I/R injury was induced by creating ischemia for 30 minutes through left anterior descending artery ligation followed by 24 h of reperfusion. Electrocardiogram analysis showed delayed RR interval and qrs complex in hfd group compared to hfd+coc; whereas, echocardiogram confirmed the dilation of left ventricle. LVIDs was increased in hfd compared to hfd+coc (0.40±0.13 cm vs 0.31±0.12cm; p&lt;0.05) and IVSd: hfd 0.19±0.12cm vs hfd+coc 0.14±0.08 cm (p&lt;0.05). Histopatology of left ventricle showed increased cellular death in hfd animals compared to hfd+coc and reduced intima-media thickness in aorta was seen in hfd±coc. Immunofluorescent analysis of ICAM showed decreased expression levels in hfd+coc group compared to hfd. Immunoblot of whole infarcted left ventricular lysate showed upregulation of EGF and VEGF in hfd+coc showed increased angiogenesis thereby protecting infracted myocardium. Conclusion: Treatment of hfd animals with ethanolic extract of Crataegus oxycantha (COC) during I/R injury improved cardiac function and myocardial viability by activating angiogenesis upon upregulation of VEGF and EGF expression levels in acute phase of injury.
SYSTEMATIC REVIEW AND META-ANALYSIS EVALUATING THE DIAGNOSTIC ACCURACY OF LEFT ATRIAL STRAIN MEASUREMENT TO ASSESS GENERAL THROMBOTIC EVENTS OF THE LEFT ATRIAL APPENDAGE
Authors: Sonali Sachdeva, Rupak Desai, Dipen Zalavadia, Zainab Gandhi, Ankita Aggarwal, Anubhav Jain
Journal: Journal of the American College of Cardiology (2021)
PROGRESSION OF CARDIOVASCULAR DISEASE IN HIV-INFECTED PATIENTS ON STABLE ANTIRETROVIRAL THERAPY DURING 1 YEAR FOLLOW-UP. A SPECKLE- TRACKING ECHOCARDIOGRAPHY STUDY
Authors: Kyriakos Yiangou, Nearchos Kasinos, Antonios Destounis, Anastasios Theodosis-Georgilas, Demetrios Beldekos
Journal: Journal of the American College of Cardiology (2021)
A CASE OF PLATYPNEA-ORTHODEOXIA SYNDROME WITH PRIMARY PULMONARY HYPERTENSION
Authors: Vijay Pratap Singh, Mousa Thalji, Swaiman Singh, Hamza Hafeez, Ajinkya Buradkar, Sangeeta Prabhakar Bhat, Chaitanya Rojulpote
Journal: Journal of the American College of Cardiology (2021)
The interplay between <i>Helicobacter pylori</i> and gastrointestinal microbiota
Authors: Chieh-Chang Chen, Jyh-Ming Liou, Yi-Chia Lee, Tzu-Chan Hong, Emad M El-Omar, Ming-Shiang Wu
Journal: Gut Microbes (2021)

The complex population of microbes in the human gastrointestinal (GI) tract interacts with itself and with the host, exerting a deep influence on health and disease development. The development of modern sequencing technology has enabled us to gain insight into GI microbes.
Abstract 14030: The Ubiquitin-Like Protein Fat10 Attenuates Cardiac Hypertrophy by Promoting the Lysosomal Degradation of CaMK2D
Authors: Yang Shen, Wei Lai, Dandan Zhang, Rong Wan, Kui Hong
Journal: Circulation (2019)

Introduction: Recent study has shown that FAT10, a ubiquitin-like protein, could protect the myocytes against ischemic apoptosis. However, the role of FAT10 in the pathogenesis of cardiac hypertrop...
FRAILTY AND OUTCOMES FOLLOWING PERCUTANEOUS VASCULAR INTERVENTIONS IN LOWER-EXTREMITY PERIPHERAL ARTERY DISEASE: INSIGHTS FROM THE VASCULAR QUALITY INITIATIVE
Authors: Mohammed Al-Damluji, Kim Smolderen, Jiaming Huang, Raul J. Guzman, Sameer Nagpal, Carlos Mena Hurtado
Journal: Journal of the American College of Cardiology (2021)
LEFT VENTRICULAR MYOCARDIAL WORK INDICES ACCORDING TO DIFFERENT REMODELING PATTERNS AFTER ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION
Authors: Rodolfo de Paula Lustosa, Surenjav Chimed, Idit Yedidya, Federico Fortuni, Pieter van der Bijl, Mohammed El Mahdiui, Jose Manuel Montero Cabezas, Marina V Kostyukevich, Juhani Knuuti, Nina Ajmone Marsan, Jeroen Bax, Victoria Delgado
Journal: Journal of the American College of Cardiology (2021)
HEART FAILURE WITH PRESERVED EJECTION FRACTION IS ASSOCIATED WITH AN IMPAIRED ANP COMPENSATORY RESPONSE WITH REDUCED CGMP AND INCREASED REHOSPITALIZATION RISK
Authors: Shawn Reginauld, Seethalakshmi Iyer, Xiao Ma, Jeson Sangaralingham, Horng Chen, John Burnett
Journal: Journal of the American College of Cardiology (2021)
CLINICAL OUTCOMES OF PATIENTS WITH DIABETES MELLITUS AND ACUTE ST ELEVATION MYOCARDIAL INFARCTION FOLLOWING FIBRINOLYTIC THERAPY, A NATIONWIDE INPATIENT SAMPLE DATABASE ANALYSIS
Authors: Waqas Ullah, Sameer Saleem, Salman Zahid, Yasar Sattar, Zain Ali, Maryam Mukhtar, Sundas Younas, Ahmed Pasha, Muhammad Shayan Khan, David L Fischman, M Chadi Alraies
Journal: Journal of the American College of Cardiology (2021)
CLINICAL OUTCOME FOLLOWING PCI IN NON-ISCHEMIC STABLE CORONARY ARTERY DISEASE BASED ON A NOVEL INDEX: COMPUTATIONAL PRESSURE-FLOW DYNAMICS DERIVED FRACTIONAL FLOW RESERVE
Authors: Ka Lam Calvin Leung, Lok Yee Lam, Kwan Yu Li, Shuk Yin Yu, Mei Zhen Wu, Qing Wen Ren, Pui Fai Wong, Yi Kei Tse, Si Yeung Yu, Hang Long Li, Yundi Feng, Yunlong Huo, Hung-Fat Tse, Kai-Hang Yiu
Journal: Journal of the American College of Cardiology (2021)
Annals Graphic Medicine - Dr. Mom: Every Night
Authors: Grace E. Farris
Journal: Annals of Internal Medicine (2021)

Web ExclusivesMay 2021Annals Graphic Medicine - Dr. Mom: Every NightFREEGrace E. Farris, MDGrace E. Farris, MDUniversity of Texas, Austin, Texas (G.E.F.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/G21-0024 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Download figure Download PowerPoint Comments0 CommentsSign In to Submit A Comment IBRAHIM GHOBRIALUPMC Mercy26 April 2021 Dr. Mom I take my hat off to all Doctor Moms; two of the busiest and most noble jobs in the world. Author, Article, and Disclosure InformationAffiliations: University of Texas, Austin, Texas (G.E.F.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=G21-0024.Author/Illustrator Information: Grace E. Farris, MD, is an assistant professor of medicine at Dell Medical School at the University of Texas in Austin, Texas.About Dr. Mom: In Dr. Mom, physician and cartoonist Grace Farris examines work–life balance while mothering and doctoring. Dr. Mom appears monthly in Annals Graphic Medicine at Annals.org.This article was published at Annals.org on 27 April 2021. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics May 2021Volume 174, Issue 5Page: W50-W51 ePublished: 27 April 2021 Issue Published: May 2021 Copyright & PermissionsCopyright © 2021 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Recent progress in nanomedicine for enhanced cancer chemotherapy
Authors: Guoqing Wei, Yu Wang, Guang Yang, Yi Wang, Rong Ju
Journal: Theranostics (2021)

As one of the most important cancer treatment strategies, conventional chemotherapy has substantial side effects and leads easily to cancer treatment failure. Therefore, exploring and developing more efficient methods to enhance cancer chemotherapy is an urgently important problem that must be solved. With the development of nanotechnology, nanomedicine has showed a good application prospect in improving cancer chemotherapy. In this review, we aim to present a discussion on the significant research progress in nanomedicine for enhanced cancer chemotherapy. First, increased enrichment of drugs in tumor tissues relying on different targeting ligands and promoting tissue penetration are summarized. Second, specific subcellular organelle-targeted chemotherapy is discussed. Next, different combinational strategies to reverse multidrug resistance (MDR) and improve the effective intracellular concentration of therapeutics are discussed. Furthermore, the advantages of combination therapy for cancer treatment are emphasized. Finally, we discuss the major problems facing therapeutic nanomedicine for cancer chemotherapy, and propose possible future directions in this field.
Impact of NFE2 mutations on AML transformation and overall survival in patients with myeloproliferative neoplasms
Authors: Clémence Marcault, Lin-Pierre Zhao, Nabih Maslah, Emmanuelle Verger, Rafael Daltro de Oliveira, Juliette Soret-Dulphy, Marine Cazaux, Nicolas Gauthier, Blandine Roux, Emmanuelle Clappier, Nathalie Parquet, Christine Dosquet, Delphine Réa, Jean-Marc Zini, William Vainchenker, Emmanuel Raffoux, Stéphane Giraudier, Jean-Jacques Kiladjian, Bruno Cassinat, Lina Benajiba
Journal: Blood (2021)
ATRIAL FIBRILLATION IN ACTIVE CANCER PATIENTS : ANALYSIS FROM THE JORDAN ATRIAL FIBRILLATION STUDY
Authors: Ismail Ramadan Tawfiq Hamam, Ibrahim Jarrad, Zaid Abdulelah, Alia Khamis, Muyasar Amro, Tamer Salhab Altamimi, Abdellbaset Al-Khatib
Journal: Journal of the American College of Cardiology (2021)
Encapsulation of Hydrophilic Compounds in Small Extracellular Vesicles: Loading Capacity and Impact on Vesicle Functions
Authors: Britta Franziska Hettich, Johannes Josua Bader, Jean‐Christophe Leroux
Journal: Advanced Healthcare Materials (2021)

Abstract Their natural functions in intercellular communication render extracellular vesicles (EV) highly attractive for drug delivery applications. However, the loading efficiency of present methods to incorporate particularly hydrophilic low molecular weight drugs of biomedical interest is largely unexplored, as is the impact these methods may have on the intrinsic structural and biological vesicle properties. Here, different methods are exploited to incorporate hydrophilic non‐membrane permeable compounds into stem cell‐derived small EV, and to assess the vesicle characteristics after the different loading processes. When comparing several methods head‐to‐head, the loading capacity increases in the order saponin ≤ sonication &lt; fusion &lt; freeze‐thawing ≤ osmotic shock. Interestingly, the structural and biological functions of small EV are dependent on the applied encapsulation process, with the functional properties being altered at a greater extent. Therefore, the importance of including additional characterization parameters to probe alterations of the biological functionality of small EV is clearly demonstrated. Here, freeze‐thawing and particularly the osmotic shock have proven to be the most appropriate methods for EV loading, as they achieve a high drug encapsulation and yet preserve the investigated structural and biological vesicle characteristics.
Silk Fibroin Scaffold Architecture Regulates Inflammatory Responses and Engraftment of Bone Marrow‐Mononuclear Cells
Authors: Nianji Yang, Matthew J. Moore, Praveesuda L. Michael, Miguel Santos, Yuen Ting Lam, Shisan Bao, Martin K. C. Ng, Jelena Rnjak‐Kovacina, Richard P. Tan, Steven G. Wise
Journal: Advanced Healthcare Materials (2021)

Despite being one of the most clinically trialed cell therapies, bone marrow-mononuclear cell (BM-MNC) infusion has largely failed to fulfill its clinical promise. Implanting biomimetic scaffolds at sites of injury prior to BM-MNC infusion is a promising approach to enhance BM-MNC engraftment and therapeutic function. Here, it is demonstrated that scaffold architecture can be leveraged to regulate the immune responses that drive BM-MNC engraftment. Silk scaffolds with thin fibers and low porosity (LP) impairs immune activation in vitro compared with thicker fiber, high porosity (HP) scaffolds. Using the authors' established in vivo bioluminescent BM-MNC tracking model, they showed that BM-MNCs home to and engraft in greater numbers in HP scaffolds over 14 days. Histological analysis reveals thicker fibrous capsule formation, with enhanced collagen deposition in HP compared to LP scaffolds consistent with substantially more native CD68+ macrophages and CD4+ T cells, driven by their elevated pro-inflammatory M1 and Th1 phenotypes, respectively. These results suggest that implant architecture impacts local inflammation that drives differential engraftment and remodeling behavior of infused BM-MNC. These findings inform the future design of biomimetic scaffolds that may better enhance the clinical effectiveness of BM-MNC infusion therapy.
Systematic Analysis of the Prognostic Impact of Somatic Mutations in Diffuse Large B-Cell Lymphoma (DLBCL) with Evaluation of Cell-of-Origin Dependence: Results from the Phase 3 GOYA Trial in Previously Untreated DLBCL
Authors: Christopher Bolen, Magdalena Klanova, Marek Trněný, Laurie H. Sehn, Umberto Vitolo, Maurizio Martelli, Günter Fingerle-Rowson, Tina Nielsen, Georg Lenz, Mikkel Z. Oestergaard
Journal: Blood (2017)
LIPOPROTEIN(A) AND VASCULAR RISK IN PATIENTS WITH ESTABLISHED CARDIOVASCULAR DISEASE
Authors: Christoph H. Saely, Lukas Sprenger, Alexander Vonbank, Barbara Larcher, Arthur Mader, Maximilian Maechler, Beatrix Mutschlechner, Daniela Zanolin-Purin, Andreas Leiherer, Axel Muendlein, Heinz Drexel
Journal: Journal of the American College of Cardiology (2021)
Cost-effectiveness Analysis of Nutrition Facts Added-Sugar Labeling and Obesity-Associated Cancer Rates in the US
Authors: Mengxi Du, Christina F. Griecci, Frederick F. Cudhea, Heesun Eom, David D. Kim, Parke Wilde, John B. Wong, Y. Claire Wang, Dominique S. Michaud, Dariush Mozaffarian, Fang Zhang
Journal: JAMA Network Open (2021)

IMPORTANCE Obesity-associated cancer burdens are increasing in the US.Nutrition policies, such as the Nutrition Facts added-sugar labeling, may reduce obesity-associated cancer rates.OBJECTIVE To evaluate the cost-effectiveness of Nutrition Facts added-sugar labeling and obesityassociated cancer rates in the US.DESIGN, SETTING, AND PARTICIPANTS A probabilistic cohort state-transition model was used to conduct an economic evaluation of added-sugar labeling and 13 obesity-associated cancers among 235 million adults aged 20 years or older by age, sex, and race/ethnicity over a median follow-up of 34.4 years.Policy associations were considered in 2 scenarios: with consumer behaviors and with additional industry reformulation.The model integrated nationally representative population demographics, diet, and cancer statistics; associations of policy intervention with diet, diet change and body mass index, and body mass index with cancer risk; and policy and health-related costs from established sources.Data were analyzed from January 8, 2019, to May 6, 2020.MAIN OUTCOMES AND MEASURES Net costs and incremental cost-effectiveness ratio were estimated from societal and health care perspectives.Probabilistic sensitivity analyses incorporated uncertainty in input parameters and generated 95% uncertainty intervals (UIs). RESULTSBased on consumer behaviors, the policy was associated with a reduction of 30 000 (95% UI, 21 600-39 300) new cancer cases and 17 100 (95% UI, 12 400-22 700) cancer deaths, a gain of 116 000 (95% UI, 83 800-153 000) quality-adjusted life-years, and a saving of $1600 million (95% UI, $1190 million-$2030 million) in medical costs associated with cancer care among US adults over a lifetime.The policy was associated with a savings of $704 million (95% UI, $44.5 million-$1450 million) from the societal perspective and $1590 million (95% UI, $1180 million-$2020 million) from the health care perspective.Additional industry reformulation to reduce added-sugar amounts in packaged foods and beverages would double the impact.Greater health gains and cost savings were expected among young adults, women, and non-Hispanic Black individuals than other population subgroups. CONCLUSIONS AND RELEVANCEThese findings suggest that the added-sugar labeling is associated with reduced costs and lower rates of obesity-associated cancers.Policymakers may consider and prioritize nutrition policies for cancer prevention in the US.
Abstract 15531: Proportion of CIED Implantation and Incidence of Appropriate Therapy in Patients With Wild-Type Amyloidogenic Transthyretin Cardiac Amyloidosis
Authors: Yusei Kawahara, Hisanori Kanazawa, Miwa Ito, Yusuke Kanemaru, Takuya Kiyama, Kenichi Tsujita
Journal: Circulation (2019)

Background and Objectives: It has been shown that cardiac conduction disorders and fatal arrhythmias can be seen in patients with wild-type amyloidogenic transthyretin (wtATTR) cardiac amyloidosis....
Biodegradable polymeric occluder for closure of atrial septal defect with interventional treatment of cardiovascular disease
Authors: Boning Li, Zhaofeng Xie, Qunsong Wang, Xianmiao Chen, Qingsong Liu, Wei Wang, Yang Shen, Jianxiong Liu, Anning Li, Yifan Li, Gui Zhang, Jianxiong Liu, Deyuan Zhang, Cong Liu, Shushui Wang, Yumei Xie, Zhiwei Zhang, Jiandong Ding
Journal: Biomaterials (2021)
Abstract 320: End-Tidal Carbon Dioxide Can Guide Fluid Resuscitation in a Cecal Ligation and Puncture Induced Rat Model of Sepsis
Authors: Jing Xu, Guanghui Zheng, Liangliang Wu, Xiangshao Fang, Yue Wang, Longyuan Jiang, Qin Ling, Zhengfei Yang, Wanchun Tang
Journal: Circulation (2018)

Introduction: Abnormal levels of end-tidal carbon dioxide (ETCO 2 ) may reflect a derangement in perfusion, metabolism, or gas exchange. It is unclear if ETCO 2 can be used for fluid resuscitation (FR) compared with traditional mean arterial pressure (MAP) as an outcome predictor in sepsis. Hypothesis: Use of ETCO2 is better than MAP in guiding fluid resuscitation to improve lactate levels and microcirculatory blood flow in sepsis. Methods: Thirty-five male Sprague-Dawley rats weighing 350-400g were randomized to: 1) SHAM, n=5; 2) cecal ligation and puncture (CLP) Control group (with CLP, without FR, n=10); 3) ETCO 2 group (with CLP, FR began when ETCO 2 ≤25 mmHg, n=10) and 4) MAP group (with CLP, FR began when MAP≤100 mmHg, n=10). Lactate level, cardiac output (CO), perfused small vessel density (PSVD) and sublingual microvascular flow index (MFI) was assessed at baseline, 2 h, 4 h, 8 h, 10 h and 12 h post-CLP. Survival duration was recorded. Results: After FR,CO in the ETCO 2 group increased compared with the MAP group 12h after CLP while lactate levels decreased compared with the Control and MAP groups (p&lt;0.05) (Figure-1). Both sublingual PSVD and MFI decreased after CLP in the control group and MAP group but significantly improved in the ETCO 2 group 8h post-CLP. The average survival time in the ETCO 2 group was significantly greater than MAP group (Figure-2). Conclusions: ETCO 2 guided FR was associated with improved CO, lactate, microcirculatory flow, and survival time compared to MAP guided FR in a CLP-induced rat model of sepsis.
Protective genes and pathways in Alzheimer’s disease: moving towards precision interventions
Authors: Mabel Seto, Rebecca L. Weiner, Logan Dumitrescu, Timothy J. Hohman
Journal: Molecular Neurodegeneration (2021)

Abstract Alzheimer’s disease (AD) is a progressive, neurodegenerative disorder that is characterized by neurodegeneration, cognitive impairment, and an eventual inability to perform daily tasks. The etiology of Alzheimer’s is complex, with numerous environmental and genetic factors contributing to the disease. Late-onset AD is highly heritable (60 to 80%), and over 40 risk loci for AD have been identified via large genome-wide association studies, most of which are common variants with small effect sizes. Although these discoveries have provided novel insight on biological contributors to AD, disease-modifying treatments remain elusive. Recently, the concepts of resistance to pathology and resilience against the downstream consequences of pathology have been of particular interest in the Alzheimer’s field as studies continue to identify individuals who evade the pathology of the disease even into late life and individuals who have all of the neuropathological features of AD but evade downstream neurodegeneration and cognitive impairment. It has been hypothesized that a shift in focus from Alzheimer’s risk to resilience presents an opportunity to uncover novel biological mechanisms of AD and to identify promising therapeutic targets for the disease. This review will highlight a selection of genes and variants that have been reported to confer protection from AD within the literature and will also discuss evidence for the biological underpinnings behind their protective effect with a focus on genes involved in lipid metabolism, cellular trafficking, endosomal and lysosomal function, synaptic function, and inflammation. Finally, we offer some recommendations in areas where the field can rapidly advance towards precision interventions that leverage the ideas of protection and resilience for the development of novel therapeutic strategies.
Clinical negligence: Doctors and managers must learn from litigation claims, say experts
Authors: Abi Rimmer
Journal: BMJ (2021)

Doctors and managers should learn from clinical negligence claims in the same way that they learn from clinical incidents, experts have said.

The Getting It Right First Time (GIRFT) programme and NHS Resolution have published a best practice guide for clinicians and managers about learning from litigation claims,1 which in 2019-20 are expected to cost the NHS £8.3bn (€9.6bn; $11.5bn).

The guidance calls for clinical negligence claims to be discussed regularly in clinical staff …
Performance of ABCD-10 and SCORTEN mortality prediction models in a cohort of patients with Stevens-Johnson syndrome/toxic epidermal necrolysis
Authors: Michael J. Duplisea, Mya L. Roberson, Lori Chrisco, Paula D. Strassle, Felicia N. Williams, Carolyn M. Ziemer
Journal: Journal of the American Academy of Dermatology (2021)
INCORPORATING CORONARY CALCIFICATION BY COMPUTED TOMOGRAPHY INTO CHA2DS2-VASC SCORE AND ASSOCIATIONS WITH CARDIOVASCULAR OUTCOMES IN ATRIAL FIBRILLATION
Authors: Tom Kai Ming Wang, Nicholas Chan, Paul Cremer, Mohamed Kanj, Bryan Baranowski, Walid Saliba, Oussama Wazni, Wael Jaber
Journal: Journal of the American College of Cardiology (2021)
Abstract 11737: Elevated Serum Phosphate Levels at Admission Are Associated With Worse Outcomes in Patients With Acute Myocardial Infarction
Authors: Hiroaki Yokoyama, Tomohide Endo, Fumie Nishizaki, Kenji Hanada, Takashi Yokota, Masahiro Yamada, Hirofumi Tomita
Journal: Circulation (2019)

Backgrounds: Although high serum phosphate levels are known to be associated with the coronary calcification, it is undetermined whether elevated serum phosphate levels would be associated with lon...