tbuckley/cabot-search huggingface dataset:
Interventions for Frailty Among Older Adults With Cardiovascular Disease
Authors: Naila Ijaz, Brian Buta, Qian-Li Xue, Denise T. Mohess, Archana Bushan, Henry Tran, Wayne Batchelor, Christopher R. deFilippi, Jeremy D. Walston, Karen Bandeen-Roche, Daniel E. Forman, Jon R. Resar, Christopher M. O’Connor, Gary Gerstenblith, Abdulla A. Damluji
Journal: Journal of the American College of Cardiology (2022)

With the aging of the world's population, a large proportion of patients seen in cardiovascular practice are older adults, but many patients also exhibit signs of physical frailty. Cardiovascular disease and frailty are interdependent and have the same physiological underpinning that predisposes to the progression of both disease processes. Frailty can be defined as a phenomenon of increased vulnerability to stressors due to decreased physiological reserves in older patients and thus leads to poor clinical outcomes after cardiovascular insults. There are various pathophysiologic mechanisms for the development of frailty: cognitive decline, physical inactivity, poor nutrition, and lack of social supports; these risk factors provide opportunity for various types of interventions that aim to prevent, improve, or reverse the development of frailty syndrome in the context of cardiovascular disease. There is no compelling study demonstrating a successful intervention to improve a global measure of frailty. Emerging data from patients admitted with heart failure indicate that interventions associated with positive outcomes on frailty and physical function are multidimensional and include tailored cardiac rehabilitation. Contemporary cardiovascular practice should actively identify patients with physical frailty who could benefit from frailty interventions and aim to deliver these therapies in a patient-centered model to optimize quality of life, particularly after cardiovascular interventions.
Presse Médicale, Paris
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Does Peanut Introduction Set The Scene For Earlier Introduction Of Other Food Allergens During Infancy?
Authors: Carina Venter, Christopher Warren, Sai Nimmagadda, Waheeda Samady, Eileen Vincent, Ruchi Gupta
Journal: Journal of Allergy and Clinical Immunology (2022)

Food allergy prevention guidance, including those from AAAAI advises early introduction of food allergens.
Noncoding genetic variation in GATA3 increases acute lymphoblastic leukemia risk through local and global changes in chromatin conformation
Authors: Hongbo Yang, Hui Zhang, Yu Luan, Tingting Liu, Wentao Yang, Kathryn G. Roberts, Mao-xiang Qian, Bo Zhang, Wenjian Yang, Virginia Perez-Andreu, Jie Xu, Sriranga Iyyanki, Da Kuang, Lena A. Stasiak, Shalini C. Reshmi, Julie Gastier-Foster, Colton Smith, Ching-Hon Pui, William E. Evans, Stephen P. Hunger, Leonidas C. Platanias, Mary V. Relling, Charles G. Mullighan, Mignon L. Loh, Feng Yue, Jun J. Yang
Journal: Nature Genetics (2022)
Waiting Room
Authors: H. CLARKE
Journal: Annals of Internal Medicine (1982)

Ad Libitum1 September 1982Waiting RoomH. CLARKE, M.D.H. CLARKE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-3-458_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe expecteddate of arrivalis here.You are aboutto make the grandslippery entrance.Welcometo the land of touch.Necessitieswill be provided,questionswill not go unanswered,but experiences differ.What one takes awayanother leaves behind.We will helpwith the first proofs.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: St. John's, Newfoundland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1982Volume 97, Issue 3Page: 458-458KeywordsTouch ePublished: 1 December 2008 Issue Published: 1 September 1982 PDF downloadLoading ...
February Podcast: ERS/TSANZ statement on management of airways diseases in pregnant women
Journal: European Respiratory Journal (2020)

As part of the February issue, the European Respiratory Journal presents the latest in its series of podcasts. Deputy Chief Editor James Chalmers interviews Peter G. Middleton (University of Sydney, Sydney, Australia) about the European Respiratory Society and the Thoracic Society of Australia and New Zealand’s new statment on the management of reproduction and pregnancy in women with airways diseases published in this issue.
An oxidation resistant pediocin PA-1 derivative and penocin A display effective anti- <i>Listeria</i> activity in a model human gut environment
Authors: Taís M. Kuniyoshi, Paula M. O’Connor, Elaine Lawton, Dinesh Thapa, Beatriz Mesa-Pereira, Sara Abulu, Colin Hill, R. Paul Ross, Ricardo P. S. Oliveira, Paul D. Cotter
Journal: Gut Microbes (2022)

Pediocin PA-1 is a class IIa bacteriocin that is particularly effective against the foodborne pathogen Listeria monocytogenes. The loss of activity of PA-1 pediocin due to methionine oxidation is one of the challenges that limit the wider application of the bacteriocin. In this study, we heterologously expressed an oxidation resistant form of pediocin PA-1, i.e., pediocin M31L, and compared its activity to that of native pediocin PA-1 and to penocin A, a pediocin-like bacteriocin that displays a narrower antimicrobial spectrum. Minimal inhibitory concentration assays revealed that pediocin M31L was as effective as PA-1 and more effective than synthetic penocin A against Listeria with negligible activity against a range of obligate anaerobic commensal gut bacterial species. The anti-Listeria activity of these pediocins was also assessed in a simulated human distal colon model assay using the L. monocytogenes, spiked at 6.5 ± 0.13 Log CFU/mL, as a bioindicator. At 24 h, pediocin M31L and penocin A (2.6 μM) reduced Listeria counts to 3.5 ± 0.4 and 3.64 ± 0.62 Log CFU/mL, respectively, whereas Listeria counts were considerably higher, i.e. 7.75 ± 0.43 Log CFU/mL, in the non-bacteriocin-containing control. Ultimately, it was established that synthetic penocin A and the stable pediocin M31L derivative, heterologously produced, display effective anti-Listeria activity in a human gut environment.
A connection found between mast cells and pain in eosinophilic esophagitis
Authors: Simin Zhang, Tetsuo Shoda, Seema Aceves, Mirna Chehade, Margaret Collins, Carla Davis, Evan Dellon, Gary Falk, Glenn Furuta, Nirmala Gonsalves, Sandeep Gupta, Ikuo Hirano, Paneez Khoury, John Leung, Kathryn Peterson, Jonathan Spergel, Joshua Wechsler, Guang-Yu Yang, Marc Rothenberg
Journal: Journal of Allergy and Clinical Immunology (2022)
Mepolizumab Demonstrates Real-world Clinical Effectiveness in both Type 2 Biomarker High and Type 2 Biomarker Low Patients with Severe Asthma
Authors: Geoffrey Chupp, Jason Lee, Mark Liu, Florence Schleich, Liam Heaney, Christian Domingo Ribas, Teresa Carrillo-Díaz, Marina Blanco Aparicio, Eva Martínez Moragón, M Guadalupe Sanchez-Herrero, Frances Gardiner, Rafael Alfonso-Cristancho, Rupert Jakes, Robert Price, Peter Howarth
Journal: Journal of Allergy and Clinical Immunology (2022)
Temporomandibular disorders
Authors: J. Durham, T. R. O. Newton-John, J. M. Zakrzewska
Journal: BMJ (2015)

5][6][7][8] They are also known to be comorbid with bruxism, depression, irritable bowel syndrome, and chronic fatigue. 6 9 10[13][14][15][16][17] Early diagnosis and explanation followed by management is likely to be key to improving prognosis and reducing the impact of this group of conditions on quality of life. 11 18The purpose of this review is to give non-specialists an overview of the diagnosis and management of TMDs.
A decade of molecular cell atlases
Authors: Stephen R. Quake
Journal: Trends in Genetics (2022)

In recent years there has been tremendous progress towards deep molecular characterization of cell types using single-cell transcriptome sequencing, creating so-called 'cell atlases'. These atlases provide a basic understanding of how different cell types of the same organism - which all share the genome - make distinct use of subsets of genes from the genome to create a variety of distinct cell types across tissues with specialized functions. In this opinion article I discuss some of the history and technological innovations that led to the development of whole-organism atlases.
Medicolegal
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Blood studies soon may show who is at risk for rheumatoid arthritis
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Full Circle
Authors: Reem A. Abu-Libdeh
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Profiling the Bisecting <i>N</i>-Acetylglucosamine Modification in Amniotic Membrane via Mass Spectrometry
Authors: Qiushi Chen, Yuanliang Zhang, Keren Zhang, Jie Liu, Huozhen Pan, Xinran Wang, Siqi Li, Dandan Hu, Zhilong Lin, Yun Zhao, Guixue Hou, Feng Guan, Hong Li, Siqi Liu, Yan Ren
Journal: Genomics Proteomics & Bioinformatics (2022)

Bisecting N-acetylglucosamine (GlcNAc), a GlcNAc linked to the core β-mannose residue via a β1,4 linkage, is a special type of N-glycosylation that has been reported to be involved in various biological processes, such as cell adhesion and fetal development. This N-glycan structure is abundant in human trophoblasts, which is postulated to be resistant to natural killer cell-mediated cytotoxicity, enabling a mother to nourish a fetus without rejection. In this study, we hypothesized that the human amniotic membrane, which serves as the last barrier for the fetus, may also express bisected-type glycans. To test this hypothesis, glycomic analysis of the human amniotic membrane was performed, and bisected N-glycans were detected. Furthermore, our proteomic data, which have been previously employed to explore human missing proteins, were analyzed and the presence of bisecting GlcNAc-modified peptides was confirmed. A total of 41 glycoproteins with 43 glycopeptides were found to possess a bisecting GlcNAc, and 25 of these glycoproteins were reported to exhibit this type of modification for the first time. These results provide insights into the potential roles of bisecting GlcNAc modification in the human amniotic membrane, and can be beneficial to functional studies on glycoproteins with bisecting GlcNAc modifications and functional studies on immune suppression in human placenta.
Analysis of Clinical Food Allergen Thresholds by Comparing Threshold Dose Distributions
Authors: Tatsuki Fukuie, Shouhei Takeuchi, Masaya Saito, Reiko Adachi, Hiroshi Akiyama, Yoshinari Suzuki, Yukihiro Ohya, Hirohisa Saito
Journal: Journal of Allergy and Clinical Immunology (2022)
Medicolegal
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tezepelumab Reduces Inflammatory Biomarkers as Early as Week 2 and Maintains Reductions Until Week 52 in the Phase 3 NAVIGATOR Severe Asthma Trial
Authors: Janet Griffiths, Tuyet-Hang Pham, Eileen Wang, Chris Ambrose, Neil Martin, Jane Parnes, Andrew Lindsley, Gillian Hunter, Gene Colice, John Oppenheimer
Journal: Journal of Allergy and Clinical Immunology (2022)
Harmonising patient-access programmes: the Dutch DRUG Access Protocol platform
Authors: Laurien J Zeverijn, Sahar Barjesteh van Waalwijk van Doorn-Khosrovani, Anke A M G Pisters van Roy, Lonneke Timmers, T H Ly Tran, Jolanda E de Boer, Gijsbrecht F de Wit, Birgit S Geurts, Hans Gelderblom, Henk M W Verheul, Nicole Blijlevens, A N Machteld Wymenga, Ferry A L M Eskens, Egbert F Smit, Haiko J Bloemendal, Emile E Voest
Journal: The Lancet Oncology (2022)
Comparative analyses of IgG/IgA neutralizing effects induced by three COVID-19 vaccines against variants of concern
Authors: Eliott Lafon, Michael Jäger, Angelika Bauer, Markus Reindl, Rosa Bellmann-Weiler, Doris Wilflingseder, Cornelia Lass-Flörl, Wilfried Posch
Journal: Journal of Allergy and Clinical Immunology (2022)

Few studies have directly compared virus-specific antibodies and their neutralizing capacity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) wild type (WT) and circulating variants of concern despite the reported high efficacy of messenger RNA (mRNA)- and vector-based vaccines.
Hospitals, Chicago
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparing Perspectives on Transition of Care for Primary Immunodeficiency Patients
Authors: Shipra Rai, Zoya Treyster, Artemio Jongco
Journal: Journal of Allergy and Clinical Immunology (2022)

RATIONALE: Selective IgA Deficiency (SIgAD) is the most commonly diagnosed primary immunodeficiency disorder (PIDD).Many patients are asymptomatic, but they can be at risk of developing recurrent infections, autoimmunity, or other PIDDs.METHODS: A retrospective chart review was performed on patients with a diagnosis of selective IgA deficiency, IgA deficiency, or low IgA level for age in the EMR from January 1, 2011 through December 31, 2020.Information gathered included patient demographics, past medical and family history, reason IgA obtained, additional immunologic evaluation, referral patterns, and clinical outcomes (prescription of prophylactic antibiotics, progression to CVID, and development of autoimmunity).SIgAD was defined as IgA <7mg/dL and partial IgA deficiency (PIgAD) as 2 standard deviations below age-adjusted mean but >7mg/dL.RESULTS: 150 charts were reviewed.Patients were categorized as SIgAD (N542), PIgAD (N59), normal IgA for age (N543), insufficient information in EMR (N525), age <4 (N521), and other immunologic abnormalities (N59).79 patients were referred to immunology.Of the 51 patients with SIgAD or PIgAD, 28 were identified after celiac disease screening.Fifteen had co-existing autoimmune conditions, the most common being Type 1 Diabetes Mellitus (N57).Four patients had recurrent infections requiring prophylactic antibiotics.Eleven patients with labs consistent with SIgAD did not have the diagnosis on their chart.CONCLUSIONS: Appropriate diagnosis of SIGAD and PIgAD and subsequent evaluation is important but not always consistent.Guidelines to help direct when further evaluation and referral to Immunology may be beneficial to ensure that proper diagnosis of SIgAD is made and applicable anticipatory guidance is given.
6. Mantle Cell Lymphomas
Authors: T Papajı, M Jarosova, V Prochazka, Z Pikalova, M Holzerova, S Vlachova, R Plachy, T Pacovska, L Raida, K Indrak, A Ferrer, F Bosch, A Lo ´pez-Guillermo, M Rozman, J Aguilar, E Campo, E Montserrat, E Kimby, A Wallblom, B Sander, A Rinaldi, I Kwee, M Taborelli, C Largo, L Baldini, G Martinelli, F Cotter, J Cigudosa, C Catapano, M Tibiletti, F Bertoni
Journal: Annals of Oncology (2005)
PREVALENCE AND RISK FACTORS FOR ASTHMA IN SCHOOLS. IS THERE A DIFFERENCE BETWEEN RURAL AND URBAN AREAS?
Authors: Elsy Navarrete Rodríguez, Silvia Martínez-Valverde, Francisco Linares-Zapien, María de la Luz Cid del Prado, Herson Brito Díaz, Lizzeth Juárez Martínez, Margarita Linares Zapién, Enrique López Valentin, Norma Ortega Santana, Adriana Peña Rueda, Luisa Pineda Bahena, Pedro Vilchis Velázquez, Osvaldo Zarco Cid del Prado, None Blanca del-Rio-Navarro, Nayeli Reyes Noriega
Journal: Journal of Allergy and Clinical Immunology (2022)
Science, Washington
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal