tbuckley/cabot-search huggingface dataset:
Comment on “A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands”
Authors: Zach Rolfs, Markus Müller, Michael R. Shortreed, Lloyd M. Smith, Michal Bassani-Sternberg
Journal: Science Immunology (2019)

There is still no convincing evidence for the frequent occurrence of posttranslationally spliced HLA-I peptides.
MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study
Authors: Richard Pötter, Kari Tanderup, Maximilian Paul Schmid, Ina Jürgenliemk-Schulz, Christine Haie-Meder, Lars Ulrik Fokdal, Alina Emiliana Sturdza, Peter Hoskin, Umesh Mahantshetty, Barbara Segedin, Kjersti Bruheim, Fleur Huang, Bhavana Rai, Rachel Cooper, Elzbieta van der Steen-Banasik, Erik Van Limbergen, Bradley Rumwell Pieters, Li-Tee Tan, Remi Abubakar Nout, Astrid Agatha Catharina De Leeuw, Robin Ristl, Primoz Petric, Nicole Nesvacil, Kathrin Kirchheiner, Christian Kirisits, Jacob Christian Lindegaard, Cyrus Chargari, Isabelle Dumas, Gerry Lowe, Jamema Swamidas, Robert Hudej, Taran Paulsen Hellebust, Geetha Menon, Arun S. Oinam, Peter Bownes, Melissa Christiaens, Marisol De Brabandere, Hilde Janssen, Bernard Oosterveld, Kees Koedooder, Anne Beate Langeland Marthinsen, Marit Sundset, Diane Whitney, Martijn Ketelaars, Ludy C.H.W. Lutgens, Brigitte Reinniers, Itxa Mora, Elena Villafranca, Gergely Antal, Janaki Hadjiev, Francois Bachand, Deidre Batchelar, Beth Erickson, Jason Rownd, Geraldine Jacobson, Yusung Kim, Maarit Anttila, Jan-Erik Palmgren, Jusheng An, Marianne Sanggaard Assenholt, Susovan Banerjee, Sören Bentzen, Thomas Berger, Pittaya Dankulchai, Tamara Diendorfer, Ian Dilworth, Johannes Dimopoulos, Elke Dörr, Stefan Ecker, Mario Federico, Elena Fidarova, Israel Fortin, Petra Georg, Joanna Gora, Neamat Hegazy, Noha Jastaniyah, Nina Boje Kibsgaard Jensen, Thomas Liederer, Katarina Majercakova, Dragan Misimovic, Laura Motisi, Dina Najjari Jamal, Karen Nkiwane, Anders Schwartz-Vittrup, Monica Serban, Stephanie Smet, Sofia Spampinato, Petra Trnkova, Margit Valgma, Henrike Westerveld, Joyce Siu Yu Wong, Kenji Yoshida
Journal: The Lancet Oncology (2021)
Effect of alteration of left ventricular activation sequence on the left ventricular end-systolic pressure-volume relation in closed-chest dogs.
Authors: R CPark, W CLittle, R AO'Rourke
Journal: Circulation Research (1985)

We investigated the effect of pacing from the atrium and various ventricular sites on the left ventricular end-systolic pressure-volume relation following autonomic blockade in a total of 10 dogs chronically instrumented to measure left ventricular pressure and determine left ventricular volume from three ultrasonic endocardial dimensions. During ventricular pacing, left ventricular end-diastolic volume, stroke volume, and end-systolic pressure were decreased, while the end-systolic volume was relatively unchanged. Left ventricular end-systolic pressure-volume relations were generated by vena caval occlusions during pacing at a constant rate from the left atria, and the epicardium of the right ventricular free wall, right ventricular apex, and left ventricular free wall. The left ventricular end-systolic pressure-volume relations were described by straight lines for each site (r greater than 0.96 and SEE less than 2.9 mm Hg in all but one instance). Compared to atrial pacing, the left ventricular end-syst...
The mural left anterior descending coronary artery, strenuous exercise and sudden death.
Authors: A RMorales, RRomanelli, R JBoucek
Journal: Circulation (1980)

Postmortem studies of three ostensibly healthy persons whose unheralded death occurred incidental to strenuous exercise revealed an obstructed but mural left anterior descending (LAD) artery, diminished vascularity to the posterior left ventricle and ventricular septum, and morphologic evidence of patchy, ischemic necrosis of the ventricular septum in different stages of healing. Although mural coronary arteries are considered a normal anatomic variant, our observations, coupled with reported clinical studies, strongly suggest that systolic constriction of the LAD artery may precipitate death in selected subjects.
The consultant's job
Authors: J. M. D. Galloway, G. M. McAndrew, I. G. Grove-White, E. J. W. Duthie, A. J. S. Gardiner, N. J. B. Hitchcock, A. W. Hutcheon, A. B. McEwan, R. J. McIlwaine, K. McLeod, J. C. Petrie, C. A. S. Pegg, M. A. Pratt, C. T. Preshaw, R. W. Strachan, W. M. Smith, H. Sutherland, A. A. Templeton
Journal: BMJ (1969)
An Excellent Model to Increase Adherence to Guideline-Directed Medical Therapy—With Far-reaching Implications
Authors: Saad Karamat, Syed Awais Ahmed, Syed Jaan Naqvi
Journal: JAMA Cardiology (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Uncovering an Optic Nerve Sheath Meningioma Using 68Ga-DOTATATE PET/CT
Authors: Sabine Ulrike Vay, Jan-Michael Werner, Christoph Kabbasch, Matthias Schmidt, Alexander Drzezga, Gereon R. Fink, Norbert Galldiks, Clemens Warnke
Journal: Clinical Nuclear Medicine (2021)

A 56-year-old woman was initially diagnosed with optic neuritis. However, several "red flags" were present: older age at presentation, no multiple sclerosis suspicious findings on MRI, and negative oligoclonal bands. 68Ga-DOTATATE PET/CT confirmed the differential diagnosis of an optic sheath meningioma. Our case stresses the value of the somatostatin receptor ligand PET/CT in patients with suspected optic neuritis if the diagnostic workup does not support immune-mediated pathogenesis.
Contractile effect of the chemotactic factors f-Met-Leu-Phe and C5a on the human isolated umbilical artery. Role of cyclooxygenase products and tissue macrophages.
Authors: FMarceau, DdeBlois, CLaplante, EPetitclerc, GPelletier, J HGrose, T EHugli
Journal: Circulation Research (1990)

Factors that are chemotactic for phagocytic leukocytes are known to elicit important acute circulatory changes, and the role of circulating leukocytes in these models is controversial. To evaluate the role of the blood vessel wall in the absence of circulating cells, spiral strips of human umbilical artery were exposed in vitro to the chemotactic peptides f-Met-Leu-Phe (1-100 nM) or C5a (2.5-25 nM). Contractile responses were observed for both peptides. Certain agonist analogues and a selective antagonist of the chemotactic action of f-Met-Leu-Phe behaved correspondingly as agonists and antagonist of the contractile effect on umbilical artery. The anaphylatoxin C3a also exerted a contractile effect on the tissue (25 nM and above), but this effect was highly tachyphylactic. Inhibitory drugs were used to examine the contributions of secondary mediators in eliciting the effects of C5a and f-Met-Leu-Phe. The contractile effect of both peptides was massively inhibited either by indomethacin or the thromboxane ...
Application of the Lung Immune Prognostic Index From Research to Clinical Practice—Reply
Authors: Dickran Kazandjian, Yutao Gong, Gideon M. Blumenthal
Journal: JAMA Oncology (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Response to Biologics in Ibd Patients Assessed by Computerized Image Analysis of Probe Based Confocal Laser Endomicroscopy With Molecular Labeling
Authors: M Iacucci, E Grisan, N Labarile, OM Nardone, SCL Smith, L Jeffery, R Cannatelli, S Ghosh, A Buda
Journal: Endoscopy (2021)

Aims The increase in therapeutic choices in inflammatory bowel diseases (IBD) imposed the identification of personalized therapeutic strategy. Confocal laser endomicroscopy (CLE) is a new endoscopic tool developed to obtain virtual in vivo histology. This study aimed to identify CLE in-vivo and ex-vivo features predictive of response for patients starting biologics.
Contrast echocardiography in single or common ventricle.
Authors: J BSeward, A JTajik, D JHagler, D GRitter
Journal: Circulation (1977)

Common ventricle is a rare congenital anomaly in which the ventricular chamber receives blood from two separate atrioventricular valves or from a common atrioventricular valve. We used contrast echocardiography during cardiac catheterization to confirm ventricular anatomy and to characterize blood flow dynamics in 35 patients with common ventricle. After injections of dye, a cloud of echoes anterior to the mitral valve echo during the rapid inflow phase of ventricular diastole is indirect evidence of common ventricle with two atrioventricular valves. Common ventricle with an outflow chamber is characterized by a smaller ventricular chamber visualized anterior to both atrioventricular valves which opacifies with subsequent ventricular systole. The arrival of all dye posterior to the only recorded atrioventricular valve further established the presence of a single atrioventricular valve. These contrast flow patterns gave greater specificity to the standard M-mode echocardiographic assessment of patients sus...
Myocardial contractile function during ischemia and hypoxia.
Authors: D GAllen, C HOrchard
Journal: Circulation Research (1987)

There is good evidence that elevated [Ca2+]i, produced by an influx of Ca2+ in exchange for Na+, is the underlying pathology in reperfusion or reoxygenation damage. Further measurements of [Na+]i and [Ca2+]i during ischemia and reperfusion, coupled with information about metabolic levels, are needed to confirm or refute this hypothesis. Contributions to cell damage by other mechanisms, e.g., oxygen free radicals, certainly cannot yet be excluded.
Long-term serial changes in left ventricular function and reversal of ventricular dilatation after valve replacement for chronic aortic regurgitation.
Authors: R OBonow, J TDodd, B JMaron, P TO'Gara, G GWhite, C LMcIntosh, R EClark, S EEpstein
Journal: Circulation (1988)

In most patients with aortic regurgitation, valve replacement results in reduction in left ventricular dilatation and an increase in ejection fraction. To determine the relation between serial changes in ventricular dilatation and changes in ejection fraction, we studied 61 patients with chronic severe aortic regurgitation by echocardiography and radionuclide angiography before, 6-8 months after, and 3-7 years after aortic valve replacement. Between preoperative and early postoperative studies, left ventricular end-diastolic dimension decreased (from 75 +/- 6 to 56 +/- 9 mm, p less than 0.001), peak systolic wall stress decreased (from 247 +/- 50 to 163 +/- 42 dynes x 10(3)/cm2), and ejection fraction increased (from 43 +/- 9% to 51 +/- 16%, p less than 0.001). Between early and late postoperative studies, diastolic dimension and peak systolic wall stress did not change, but ejection fraction increased further (to 56 +/- 19%, p less than 0.001). The increase in ejection fraction correlated with magnitude ...
Targeting CXCR2 inhibits the progression of lung cancer and promotes therapeutic effect of cisplatin
Authors: Yuan Cheng, Fei Mo, Qingfang Li, Xuejiao Han, Houhui Shi, Siyuan Chen, Yuquan Wei, Xiawei Wei
Journal: Molecular Cancer (2021)

Abstract Background Drug-resistance and severe side effects of chemotherapeutic agents result in unsatisfied survival of patients with lung cancer. CXCLs/CXCR2 axis plays an important role in progression of cancer including lung cancer. However, the specific anti-cancer mechanism of targeting CXCR2 remains unclear. Methods Immunohistochemical analysis of CXCR2 was performed on the microarray of tumor tissues of clinical lung adenocarcinoma and lung squamous cell carcinoma patients. CCK8 test, TUNEL immunofluorescence staining, PI-Annexin V staining, β-galactosidase staining, and Western blot were used to verify the role of CXCR2 in vitro. Animal models of tail vein and subcutaneous injection were applied to investigate the therapeutic role of targeting CXCR2. Flow cytometry, qRT-PCR, enzyme-linked immunosorbent assay (ELISA), and immunohistochemistry analysis were performed for further mechanistic investigation. Results The expression of CXCR2 was elevated in both human lung cancer stroma and tumor cells, which was associated with patients’ prognosis. Inhibition of CXCR2 promoted apoptosis, senescence, epithelial-to-mesenchymal transition (EMT), and anti-proliferation of lung cancer cells. In vivo study showed that tumor-associated neutrophils (TANs) were significantly infiltrate into tumor tissues of mouse model, with up-regulated CXCLs/CXCR2 signaling and suppressive molecules, including Arg-1 and TGF-β. SB225002, a selective inhibitor of CXCR2 showed promising therapeutic effect, and significantly reduced infiltration of neutrophils and enhanced anti-tumor T cell activity via promoting CD8 + T cell activation. Meanwhile, blockade of CXCR2 could enhance therapeutic effect of cisplatin via regulation of neutrophils infiltration. Conclusions Our finds verify the therapeutic effects of targeting CXCR2 in lung cancer and uncover the potential mechanism for the increased sensitivity to chemotherapeutic agents by antagonists of CXCR2.
Training for minor surgery in general practice during preregistration surgical posts.
Authors: M Pringle, J Hasler, P De Marco
Journal: BMJ (1991)

To study the teaching of minor surgery to preregistration house officers in surgery and their confidence in their skills.Questionnaire survey of consultants and vocational trainees.Trent, Oxford, and East Anglian Regional Health Authorities.All consultant surgeons (n = 148) with preregistration house officers on their firm and all first year vocational trainees in general practice (n = 165).Time spent teaching minor surgery to preregistration house officers; source of teaching; trainees' confidence in their skills in 15 minor surgical procedures and degree of confidence that consultants expected their junior house officers to achieve.137 (93%) consultants and 139 (84%) vocational trainees replied; 131 of the consultants' replies and all the trainees' replies were analysable. Only 14 consultants had a curriculum for teaching junior house officers, and 90 offered less than four hours' teaching a week. Only 11 trainees thought that their firm had had a curriculum, and 102 reported having received under two hours' teaching a week. The consultants indicated that they did most of the teaching, but the trainees reported having received most of their teaching from junior registrars. Seventy nine consultants attempted to teach minor surgery. They expected their junior house officers to acquire greater confidence in their skills in minor surgery than did the other consultants, but overall the confidence expected was low. The trainees were more confident than the consultants expected them to be, but overall confidence was still low. Those who had received more teaching were significantly more confident.The educational potential of the post of preregistration house officer in surgery seems underexploited, particularly with regard to teaching skills in minor surgery.
Effects of glucose, insulin and potassium infusion on tissue metabolic changes within first hour of myocardial infarction in the baboon.
Authors: L HOpie, KBruyneel, POwen
Journal: Circulation (1975)

The effects of infusions of glucose, insulin and potassium (GIK) on the heart tissue metabolic changes found in adult baboons 60 min after coronary artery ligation were studied. Biopsies taken from 11 baboons without coronary artery ligation gave control values. A second group of 46 baboons had coronary artery ligation. A third group of 17 baboons received an infusion of KCl after coronary artery ligation. A fourth group of 26 baboons received infusion of GIK. Coronary artery ligation resulted in the expected fall of ATP, creatine phosphate, glycogen, tissue (K+/Na+) ratio, and tissue pH, and rise of inorganic phosphate, lactare, lactate/pyruvate ratio and alpha-glycerophosphate in the infarction zones. Compared with ligation, additional infusions of GIK approximately doubled the contents of creatine phosphate and glycogen in the infarct zones, increased the content of ATP in the central infarct zone, and decreased the content of inorganic phosphate in the peripheral infarct zone. Other GIK effects were t...
Effects of age, sex, and menopausal status on plasma lipoprotein(a) levels. The Framingham Offspring Study.
Authors: J LJenner, J MOrdovas, SLamon-Fava, M MSchaefer, P WWilson, W PCastelli, E JSchaefer
Journal: Circulation (1993)

BACKGROUNDLipoprotein(a) [Lp(a)] is an atherogenic particle that structurally resembles a low density lipoprotein (LDL) particle but contains a molecule of apolipoprotein(a) attached to apolipoprotein B-100 by a disulfide bond. Because elevated plasma levels of Lp(a) have been shown to be an independent risk factor for coronary artery disease, it is important to define normal ranges for this lipoprotein.METHODS AND RESULTSWe have measured Lp(a) in 1,284 men (mean age, 48 +/- 10 years) and 1,394 women (mean age, 48 +/- 10 years) free of cardiovascular and cerebrovascular disease and not on medications known to affect lipids who were seen at the third examination cycle of the Framingham Offspring Study. Plasma Lp(a) levels were measured by an enzyme-linked immunosorbent assay, which uses a capture monoclonal anti-apo(a) antibody that does not cross-react with plasminogen, and a polyclonal anti-apo(a) antibody conjugated to horseradish peroxidase. The assay was calibrated to total Lp(a) mass. The Lp(a) fre...
Catheter Ablation Compared With Drug Therapy for Atrial Fibrillation—Reply
Authors: Douglas L. Packer, Daniel B. Mark, Kerry L. Lee
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Estimation of myocardial infarct size with ultrasonic tissue characterization.
Authors: K BSagar, L RPelc, T LRhyne, JHoward, D CWarltier
Journal: Circulation (1991)

BACKGROUNDUltrasonic tissue characterization (UTC) can distinguish normal from infarcted myocardium. Infarcted myocardium shows an increase in integrated backscatter and loss of cardiac cycle-dependent variation in backscatter. The cyclic variation of backscatter is closely related to regional myocardial contractile function; the latter is a marker of myocardial ischemia. The present study was designed to test the hypothesis that intramural cyclic variation of backscatter can map and estimate infarct size.METHODS AND RESULTSTransmural myocardial infarction was produced in 12 anesthetized, open-chest dogs by total occlusion of the left anterior descending coronary artery for 4 hours. A real-time ultrasonic tissue characterization instrument, which graphically displays integrated backscatter Rayleigh 5, cardiac cycle-dependent variation, and patterns of cyclic variation in backscatter, was used to map infarct size and area at risk of infarction. Staining with 2,3,4-triphenyltetrazolium chloride (TTC) and Pa...
Optical recordings of the effect of electrical stimulation on action potential repolarization and the induction of reentry in two-dimensional perfused rabbit epicardium.
Authors: S BKnisley, B CHill
Journal: Circulation (1993)

BACKGROUNDProlonged membrane depolarization induced by an electric shock in the heart may produce propagation block leading to repetitive beats. We studied prolonged depolarization and its role in repetitive beats in a thin epicardial layer of endocardially prefrozen arterially perfused rabbit heart.METHODS AND RESULTSA laser scanner recorded optical action potentials at 63 sites within a 1-cm2 area on the left ventricle of hearts stained with potentiometric fluorescent dye. Pacing (S1) produced propagation across the myofibers; then, a 3-millisecond shock (S2) given in the S1 refractory period produced an electric field that decreased in strength with distance along the fibers. The S2 strengths at the center of the scanned region (C) were 2.1 +/- 0.2 or 5.6 +/- 0.3 V/cm (mean +/- SD, n = 4). Repetitive beats occurred in 50% of hearts when C was 2.1 V/cm and in 100% of hearts when C was 5.6 V/cm. With each occurrence of repetitive beats, prolonged depolarization of the shocked action potential occurred wi...