tbuckley/cabot-search huggingface dataset:
SP0126 Multidisciplinary care in the local communities, at home and in self-help groups
Authors: W Bobiatynska, J Szechinski
Journal: Annals of the Rheumatic Diseases (2001)

<h3></h3> The authors discuss existing models of care for rheumatic patients and the concept of "good practices". The strategy of "good practices" is based on the assumption, that realisation of any design or project, also those concerning health care, depends not only on economic conditions and shortages, but also on what people think about it, on their aspirations, knowledge and imagination. The authors come to the conclusion that the strategy of "good practices" would be important particularly for multidisciplinary care provided in the local communities, for rehabilitation at home and in self-help groups. Many countries, especially those in central and Eastern Europe, are facing the problems with health care reforms. They are trying to learn from others and look for recommendations, in the hope, that this will help them to avoid some mistakes and overcome barriers of development. The authors examine the question of recommendations concerning "good practice" in multidisciplinary community care and the involvement of self-help groups in rehabilitation of rheumatic patients. It is suggested that in this area only some general guidelines can be stated. The models of good &nbsp;practice can be conditional, not universal. So, the reasonable way of learning from others is to discuss the problems and not simply to imitate the existing patterns.
Correspondence on ‘Influence of COVID-19 pandemic on decisions for the management of people with inflammatory rheumatic and musculoskeletal diseases: a survey among EULAR countries’
Authors: Shamma Al Nokhatha, Neil MacEoin, Richard Conway
Journal: Annals of the Rheumatic Diseases (2021)

We read with interest the article by Dejaco et al recently published in Annals of the Rheumatic Disease on the influence of the COVID-19 pandemic on decisions on the management of individuals with rheumatic diseases.1 One issue not touched on in this article is attitudes to vaccination, particularly influenza vaccination, in the COVID-19 era. Seasonal influenza infection is a major cause of morbidity and mortality in selected individuals with altered immune response.2 Influenza vaccination is recommended for the majority of individuals with autoimmune inflammatory rheumatic diseases.3

Previous studies of patients with autoimmune diseases in general and rheumatologic conditions in particular have demonstrated low uptake for influenza vaccine.4 5 The median vaccination coverage rate was 47.1% for 3 seasons in 2015–2018 among older age groups within Europe.5 Various reasons have been suggested for low influenza vaccination uptake, from patient belief that the vaccination is ineffective, perceived financial cost, concerns regarding adverse side effects of vaccination, lack of patient education, to a patient’s own underestimation of their own health risk profile.6–9

In the current context of the COVID-19 global pandemic, public …
The Future of Gene Patents and the Implications for Medicine
Authors: Jacob S. Sherkow, Henry T. Greely
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Rapid establishment of a COVID-19 critical care unit in a convention centre: the Nightingale Hospital London experience
Authors: Alastair G. Proudfoot, Ben O’Brien, Richard Schilling, Doug W. Gould, Alan McGlennan, Andrew Wragg, Charles Knight, Shaun McAuliffe, Gail Marshall, Izabella Orzechowska, Eammon Sullivan, Natalie Grey, Natalie Forrest
Journal: Intensive Care Medicine (2021)
The Need for an Improved Evidence Base to Inform the Health Care Decision-making Process—Reply
Authors: Jean-Eric Tarride, J. Michael Paterson, Mehran Anvari
Journal: JAMA Surgery (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Comprehensive molecular characterization of gastric cancer patients from phase II second-line ramucirumab plus paclitaxel therapy trial
Authors: Seung Tae Kim, Jason K. Sa, Sung Yong Oh, Kyung Kim, Jung Yong Hong, Won Ki Kang, Kyoung-Mee Kim, Jeeyun Lee
Journal: Genome Medicine (2021)

Abstract Background Gastric cancer (GC) is a heterogenous disease consisted of several subtypes with distinct molecular traits. The clinical implication of molecular classification has been limited especially in association with treatment efficacy of ramucirumab or various targeted agents. Methods We conducted a prospective non-randomized phase II single-arm trial of ramucirumab plus paclitaxel as second-line chemotherapy in 62 patients with metastatic GC who failed to respond to first-line fluoropyrimidine plus platinum treatment. For integrative molecular characterization, all patients underwent pre-ramucirumab treatment tissue biopsy for whole-exome/whole-transcriptome sequencing to categorize patients based on molecular subtypes. We also systematically performed integrative analysis, combining genomic, transcriptomic, and clinical features, to identify potential molecular predictors of sensitivity and resistance to ramucirumab treatment. Results Sixty-two patients were enrolled in this study between May 2016 and October 2017. Survival follow-up in all patients was completed as of the date of cut-off on January 2, 2019. No patient attained complete response (CR), while 22 patients achieved confirmed partial response (PR), resulting in a response rate (RR) of 35.5% (95% CI, 23.6–47.4). According to TCGA molecular classification, there were 30 GS, 18 CIN, 3 EBV, and 0 MSI tumors. The RR was 33% in GS (10/30), 33% in CIN (6/18), and 100% in EBV-positive GC patients with significant statistical difference for EBV(+) against EBV(−) tumors ( P = 0.016; chi-squared test). Moreover, responsive patients were marked by activation of angiogenesis, VEGF, and TCR-associated pathways, while non-responder patients demonstrated enrichments of sonic hedgehog signaling pathway and metabolism activity. Integrative multi-layer data analysis further identified molecular determinants, including EBV status, and somatic mutation in GNAQ to ramucirumab activity. Conclusions Prospective molecular characterization identified a subset of GC patients with distinct clinical response to ramucirumab therapy, and our results demonstrate the feasibility of personalized therapeutic opportunities in gastric cancer. Trial registration The study was registered on ClinicalTrial.gov ( NCT02628951 ) on June 12, 2015.
Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation
Authors: Pablo Largo-Barrientos, Nuno Apóstolo, Eline Creemers, Zsuzsanna Callaerts-Vegh, Jef Swerts, Caitlin Davies, Joseph McInnes, Keimpe Wierda, Bart De Strooper, Tara Spires-Jones, Joris de Wit, Valerie Uytterhoeven, Patrik Verstreken
Journal: Neuron (2021)

Tau is a major driver of neurodegeneration and is implicated in over 20 diseases. Tauopathies are characterized by synaptic loss and neuroinflammation, but it is unclear if these pathological events are causally linked. Tau binds to Synaptogyrin-3 on synaptic vesicles. Here, we interfered with this function to determine the role of pathogenic Tau at pre-synaptic terminals. We show that heterozygous knockout of synaptogyrin-3 is benign in mice but strongly rescues mutant Tau-induced defects in long-term synaptic plasticity and working memory. It also significantly rescues the pre- and post-synaptic loss caused by mutant Tau. However, Tau-induced neuroinflammation remains clearly upregulated when we remove the expression of one allele of synaptogyrin-3. Hence neuroinflammation is not sufficient to cause synaptic loss, and these processes are separately induced in response to mutant Tau. In addition, the pre-synaptic defects caused by mutant Tau are enough to drive defects in cognitive tasks.
Ethnic Disparity in Intracranial Hemorrhage Among Anticoagulated Patients With Atrial Fibrillation: An Answer in Search of a Question?⁎⁎Editorials published in the Journal of American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Authors: Rodney H. Falk
Journal: Journal of the American College of Cardiology (2007)
Dysbiosis in food allergy and implications for microbial therapeutics
Authors: M. Cecilia Berin
Journal: Journal of Clinical Investigation (2021)

The increase in food allergy prevalence in recent years suggests that environmental factors, such as diet and intestinal microbiota, play contributory roles. In this issue of the JCI, Bao et al. compared twins that differed with respect to food allergies. The researchers analyzed sequences from microbe ribosomal RNA and profiled microbe metabolites, identifying health-associated microbes at the species level. In addition to revealing microbes from the Clostridia class enriched in healthy twins, the authors identified two commensal species (Phascolarctobacterium faecium and Ruminococcus bromii) related to the healthy fecal metabolome. This study advances the goal for next-generation probiotic therapies that effectively treat or prevent food allergy.
Effect of Tidal Volume on Pulmonary Outcomes After Surgery
Authors: Chunmei Zhao, Yuesong Pan, Fang Luo
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SAT0038 Evaluation by dual x-ray absorptiometry (dxa) of body composition in ankylosing spondylitis(as) patients
Authors: E Mendonça, VM Montenegro, C Belleza, L Takayama, FR Lima, CR Gonçalves, LR Battistella
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> <h3>Objectives</h3> To evaluate body composition in patients with severe AS of long duration and predominant axial involvement by DXA. <h3>Methods</h3> Forty-one AS male patients with mean age 38,9 ± 7,26 sd years old (23–50 years), and thirty-four controls matched for age, sex, race, weight, height were studied. Body composition was measured by DXA (HOLOGIC QDR 2000) and was compared in the two groups. BMD was also measured in two sites: lumbar spine (L1-L4) and femoral neck. Comparisons were performed for the group of patients and controls. Differences were analysed using x2-test, Student test and Pearson test. Statistical significance was taken at p &lt; 0,05. <h3>Results</h3> Body-composition indexes (BMD g/cm<sup>2</sup>, BMC g/cm<sup>2</sup>, fat mass, lean mass, fat mass percentage) were analysed. Patients with AS had a lower total lean mass (47,72 kg ± 5,82 sd/55,34 kg ± 5,48 sd.) and lower total bone mass (1,04 g/cm<sup>2 ± 0</sup>.96 sd/1,13 g/cm<sup>2 ± 1</sup>,16 sd) in comparison with controls. The analysis of BMD-lumbar spine and BMD-femoral neck showed low values (0,996 g/cm<sup>2 ± 0</sup>,20sd/0,752 ± 0,15 sd) respectively. The diagnosis of osteoporosis/osteopenia was made by WHO criteria. Additionaly, there was a difference in the fat mass percentage, but it may be result of age rather than of disease. There was a significant correlation between the reduction of lean mass and bone mass and Schober test, weight and height (p &lt; 0,05). <h3>Conclusion</h3> Measures of body composition in AS patients can be important to investigate strutural severity of the disease, so prevention of deformity can be promoted early. Low values of lean mass was observed in parallel with osteoporosis, that is frequent finding in male patients with AS. This analysis showed a positively correlation between lower total lean/bone mass and anthropometric measures, probably secondary to the pathologic loss of mobility in the spine and rizomelic joints. Then, this appropriate evaluation of the musculo-skeletal changes may be a new approach for effective rehabilitation in AS patients.
The impact of changes in service delivery in patients with colorectal cancer during the first peak of the COVID-19 pandemic.
Authors: Konstantinos Kamposioras, Kok Haw Jonathan Lim, Mark P. Saunders, Kalena Marti, Daniel Anderson, Mark Cutting, Danielle McCool, Jacqueline Connell, Lilly Simpson, Jurjees Hasan, Michael Braun, Victoria Lavin, Saifee Mullamitha, Jorge Barriuso
Journal: Journal of Clinical Oncology (2021)

28 Background: Increased levels of anxiety and distress in both patients and physicians have been reported in response to the significant impact COVID-19 has on cancer service delivery globally. We aimed to investigate how these changes have been perceived by patients diagnosed with colorectal cancer and identify determinants of increased anxiety. Methods: Survey (32-item) of consecutive patients diagnosed with colorectal cancer attending a large tertiary comprehensive cancer centre in the United Kingdom (18 May to 1 July 2020). Self-reported GAD-7 (both paper/electronic forms) was used as a screening tool for anxiety. Statistical analyses of associations:Chi-square, Fisher’s exact, and uni- and multi-variable analyses were performed using SPSS v19 and R. Results: A total of 143 patients (response rate 67%), 82% male, and median age of 61-70 years were included. Majority of patients had telephone consultation (78%), including 40% who had scan results discussed over the phone; with favourable feedback received with both respectively. Twenty-three patients (18%) were considered to have anxiety, with 7 (6%) scoring for moderate or severe anxiety. Three items asked patients if they had concerns about getting COVID-19, were worried that COVID-19 would have effect on mental health, and affect their experience of cancer care. Patients answering positively to any of these items were most likely to have anxiety; multivariate analysis – OR 2.361 (95% CI 1.187-4.694, p=0.014), 3.219 (95% CI 1.401-7.395, p=0.006) and 3.206 (95% CI 1.036-9.920, p=0.043), respectively. Majority of the patients did not feel that they needed support during the pandemic period and hence the available well-being services were not used. Patients felt that friends and family had been very supportive but less so the primary care services (p&lt;0.05). However, they felt they were supported by the clinical team. Conclusions: At our centre, during the first-peak of COVID-19 pandemic in the UK, patients with colorectal cancer did not display increased rates of significant anxiety. The findings of this survey suggests that some service changes implemented, including increased telephone follow-up, may have already improved the overall experience of cancer care. Importantly, patients were much more concerned about their cancer treatment than COVID-19, emphasising the need to continue to provide comprehensive cancer care even if we get a “2nd wave” of COVID-19.
Shape of glass and amount of alcohol poured: comparative study of effect of practice and concentration
Authors: Brian Wansink, Koert van Ittersum
Journal: BMJ (2005)

<h3>Abstract</h3> <b>Objective</b> To determine whether people pour different amounts into short, wide glasses than into tall, slender ones. <b>Design</b> College students practised pouring alcohol into a standard glass before pouring into larger glasses; bartenders poured alcohol for four mixed drinks either with no instructions or after being told to take their time. <b>Setting</b> University town and large city, United States. <b>Participants</b> 198 college students and 86 bartenders. <b>Main outcome measures</b> Volume of alcohol poured into short, wide and tall, slenderglasses. <b>Results</b> Aiming to pour a "shot" of alcohol (1.5 ounces, 44.3 ml), both students and bartenders poured more into short, wide glasses than into tall slender glasses (46.1 ml <i>v</i> 44.7 ml and 54.6 ml <i>v</i> 46.4 ml, respectively). Practice reduced the tendency to overpour, but not for short, wide glasses. Despite an average of six years of experience, bartenders poured 20.5% more into short, wide glasses than tall, slender ones; paying careful attention reduced but did not eliminate the effect. <b>Conclusions</b> To avoid overpouring, use tall, narrow glasses or ones on which the alcohol level is premarked. To avoid underestimating the amount of alcohol consumed, studies using self reports of standard drinks should ask about the shape of the glass.
AB0009 Tnf alpha as a marker of articular involvement in patients infected with hiv
Authors: GG Bagnato, C Romano, C Arrigo, G Chirico
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> In the last years great attention was given to the problems correlated to Hiv infection. The clinical rheumatologic manifestations correlated to Hiv infection generally are olygo-polyarthritis, polyarthritis or Reiter Syndrome. The Hiv arthritis usually olygoarticular and asymmetric, involves the big articulations and it isn't correlate to Hla B27 aplotype. Some studies demonstrated an articular involvement in about 30% of the patients. Seems that the particular problems are correlated with a disregulation of the immune system with a sovraexpression of some pro-inflammatory cytokines. <h3>Objectives</h3> Aim of this study was to evaluate the prevalence of rheumatologic manifestations in patients with Hiv infection and to evaluate if there was a correlation between articular involvement and sovraexpression of TNF alpha that is such important in articular omeostasis. <h3>Methods</h3> We selected 46 patients with Hiv infetion, mean age 39 (22–59),10 healthy subjects and 10 with rheumatoid arthritis as negative and positive controls. At the beginning of this study we did an articular evaluation with a questionnaire with 10 items regarding rheumatological problems in all the Hiv+ patients. <h3>Results</h3> We found rheumatologic manifestations in 11(24%) and the most common was the presence of diffuse polyartralgias. Seric TNF alpha levels were increased in the Hiv group with articular involvement and was normal in those without articular involvement (p = 0,02) but there weren't statistical differences between the 2 groups for CD4 count and viral load. <h3>Conclusion</h3> TNF alpha seems to be a clear index of articular involvement in patients with HIV infection but doesn't seems to be correlated to viral load and progression of disease.