tbuckley/cabot-search huggingface dataset:
Role of Natural Killer Cell Alloreactivity in HLA-Mismatched Hematopoietic Stem Cell Transplantation
Authors: Loredana Ruggeri, Marusca Capanni, Myriam Casucci, Isabella Volpi, Antonella Tosti, Katia Perruccio, Elena Urbani, Robert S. Negrin, Massimo F. Martelli, Andrea Velardi
Journal: Blood (1999)
Abstract 4239: Speckle Tracking Imaging Detects Sub-Clinical Myocardial Dysfunction in Asymptomatic Patients with Type 2 Diabetes Mellitus
Authors: Laura Ernande, Cyrille Bergerot, Ernst R Rietzschel, Marc L De Buyzere, Nico Van de Veire, Michel Ovize, Aurélie Decaudain, Philippe Moulin, Thierry C Gillebert, Genevieve A Derumeaux
Journal: Circulation (2008)

Diabetic cardiomyopathy, a major complication of diabetes mellitus (DM), is preceded by a silent phase of progressive left ventricular (LV) remodeling. Our aim was to evaluate whether speckle tracking imaging (STI) was able to detect early, sub-clinical myocardial dysfunction in a population of asymptomatic type II DM patients with no signs or history of heart disease and a normal conventional echo . 114 patients with type II DM (52 ± 4 years, 45 females, HbA1c 7.7 ± 1.4%) and 88 age-matched healthy volunteers (HV) without any cardiovascular risk factor (52 ± 3 years, 58 females) underwent a conventional and STI echocardiography (Vivid 7, GE). Mean longitudinal strain (S L ) was assessed from the basal, mid and apical segments of the myocardial walls in apical 2- and 4-chamber views. Mean radial strain (S R ) was calculated from the short-axis view at the midventricular level. Univariate and multivariate regression analyses were used to identify the parameters contributing to the difference in S L and S R between the 2 groups. Variables used for analysis were as follows: DM, gender, BMI, systolic (sBP) and diastolic blood pressure (dBP), heart rate, IVSd and PWd thickeness, LV end-diastolic (LVEDD) and end-systolic diameters (LVESD). Clinical, conventional echo and STI parameters in the 2 groups are summurized in the table . On univariate analysis, factors associated with a significant lower strain in type II DM patients were: DM, male gender, BMI, sBP and dBP for S L and DM, sex and LVESD for S R (p&lt;0.05 for all). On multiple regression analysis, the only factors accociated with a significant decrease in strain in the DM group were DM (p = 0.005) and male gender (p = 0.008) for S L and DM (p = 0.01) for S R . STI is able to early detect subclinical myocardial dysfunction in a population with Type II DM. This decrease in S L and S R might be considered as a preclinical marker of diabetic cardiomyopathy.
Abstract 2944: Activation of Heat Shock Proteins and Shifts in Cytoskeleton Composition in a Cardiac-specific SERCA2 KO Mouse
Authors: Cathrine Husberg, Giulio Agnetti, Staale Nygaard, Kristin Breivik Andersson, Geir Christensen, Jennifer Van Eyk
Journal: Circulation (2009)

BACKGROUND: Depressed contractility is a key feature of the failing heart and has been linked to reduced Ca2+ availability due to decreased activity of the sarcoplasmic reticulum Ca2+ ATPase 2 (SER...
Abstract 14349: Conditional Dicer Deletion in Adult Hearts Induces miR15b Expression, Mitochondrial Dysfunction and Oxidative Stress
Authors: Sashwati Roy, Jaideep Banerjee, Surya C Gnyawali, Savita Khanna, Chandan K Sen
Journal: Circulation (2010)

Dicer, an endonuclease required for the processing of miRNA to their mature form. A central role of miRNA in cardiac development and function has been proposed. Decreased levels of Dicer have been ...
Abstract 18075: Resource Utilization in Patients with Mitral Regurgitation Before and After Surgical Intervention: An Analysis of the Centers for Medicare and Medicaid Services Database
Authors: Kimberly N Hong, Alexander Iribarne, Deborah Ascheim, Alan Moskowitz, Annetine Gelijns, Mark J Russo
Journal: Circulation (2011)

PURPOSE: The purpose of this study is to characterize resource utilization in Medicare beneficiaries with mitral regurgitation by comparing hospitalization rates and costs before and after surgical intervention. METHODS: De-identified inpatient claims data were obtained from the Centers for Medicare and Medicaid services for 1/1/2001 to 12/31/2005. Medicare beneficiaries with functional mitral regurgitation (ICD9: 424.0) who received mitral valve surgery (ICD9 codes: 35.12, 35.23, 35.24, 35.33) during this time period were included in analysis (N=68,344). Only claims data 1 year before (N=44,190) and 1 year after surgical intervention (N=78,600) was analyzed. Costs from surgical intervention hospitalization was excluded from analysis. Outcome measures included median inpatient costs, hospitalization rates and length of stay. Costs were estimated using ratio-of-costs-to-charges, and age-adjusted hospital costs were compared using quantile regression. Primary ICD9 diagnosis code was used to categorize type of hospitalization. RESULTS (TABLE): Median hospitalization costs for patients prior to surgical intervention were higher than after (p&lt;0.05). Mean hospitalization rate in the year prior to surgical intervention was lower than in the year immediately following (p&lt;0.001). Mean LOS was also longer after surgical intervention compared to before (p&lt;0.001). A greater proportion of hospitalizations before surgery were associated with Congestive Heart Failure (ICD9: 428.0) compared to after (p&lt;0.001). CONCLUSIONS: Even though LOS and readmission rates are higher in Medicare beneficiaries in the year following surgical intervention, hospitalization costs are significantly lower. This may be secondary to fewer Congestive Heart Failure hospitalizations after surgical intervention.
Medicine and books: Shell-Shock: A History of the Changing Attitude to War Neurosis
Authors: Richard Earlam
Journal: BMJ (1998)

Anthony Babington 

Leo Cooper, £16.95, pp 224 

ISBN 085052 5624 

The failure to compensate psychologically for the trauma of war has been called many things over the years. This important book charts the shifts in attitudes that have accompanied the changing names. 

In 1678, a Swiss physician coined the term “nostalgia” to mean a soldier’s fear that he would never see his homeland again. Other early diagnoses included soldier’s heart, battle hysteria, fatigue, and exhaustion. The authorities soon realised, however, that if doctors diagnosed these conditions too readily then armies might disappear. Responding to this threat, the British army forbad the discharge of insane soldiers in 1863. 

“Windage” appeared in the American Civil War and was ascribed to shock waves from large shells passing nearby. By then, swords and muzzle loading guns had been replaced by larger explosives and shrapnel. Technological advances, such as the Gatling machine gun (1862), are difficult to appreciate in a world where Kalashnikov rifles are on sale at the nearest bazaar. 

The first use of the term “shell-shock” was in 1915 by Charles Myers, of Britain’s Royal Army Medical Corps. The war office adopted the term as a “diagnostic classification of officers and men in the British forces caused by their experience in battle.” The problem was to differentiate it from malingering, so a diagnosis of NYDN (not yet diagnosed nervous) was introduced. By the end of the first world war, 80 000 British soldiers had been diagnosed with shell-shock. Some 346 had been executed by firing squad for desertion or cowardice. 

Read this book if you are interested in the response to injury nowadays labelled post-traumatic stress disorder. Its author was rehabilitated in Cairns’s neurosurgical unit at Oxford for injuries received in the second world war. Although disabled, he trained in law after the war and became a judge.
Effect of combined treatment of bortezomib and valproic acid on multiple myeloma cells
Authors: B. Kim, K. Ahn, I. Kim, S. Park, B. Kim, S. Yoon
Journal: Journal of Clinical Oncology (2007)

18539 Background: Valproic acid (VPA) has an activity of histone deacetylase inhibitor that is known to have in vitro cytotoxic effect on multiple myeloma (MM) cells. It was investigated that VPA could synergize with bortezomib for human MM cell lines. Methods: U266 cell lines were treated with bortezomib 50nM and/or VPA 0.6mM and then MTT assay, cell cycle analysis using FACS, immunoblot analysis, caspase-3 activity assay, and IL-6 ELISA assay were performed. Results: Bortezomib activated caspase-3 and induced G1 cell cycle arrest. In MTT assay, VPA suppressed the U266 cell proliferation with IC50 of 0.6mM and combined treatment of bortezomib and VPA had more inhibitory effect than bortezomib alone. This combination caused further G1 cell cycle arrest, caspase-3 activation, and lowered IL-6 secretion from U266 cells than bortezomib, respectively. In immunoblot analysis, this combination further decreased the expression of cyclin A, cyclin D1, cyclin E, CDK2, CDK4, and CDK6, whereas up-regulated p21 and p27 expression than bortezomib alone. Conclusions: The combined treatment of bortezomib and VPA has a more significant anti-myeloma effect than bortezomib alone. No significant financial relationships to disclose.
Abstract P123: The Association of Inflammatory Markers with Subsyndromal Depression the Multi-Ethnic Study of Atherosclerosis
Authors: Alvaro Camacho
Journal: Circulation (2013)

Objective. Subsyndromal (mild) depression can be a disabling condition that has been associated with increased cardiovascular risk, yet mechanisms governing this association are unclear. Some studies indicate that clinical depression is associated with higher levels of inflammation, yet this association has not been explored in subsyndromal depression. Therefore we examined the association between inflammatory markers and subsyndromal depression. Methods. Blood levels of C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF) were measured in a cross-sectional analysis of 6814 participants from the Multi-Ethnic Study of Atherosclerosis (MESA). Based on scores from the Center for Epidemiologic Studies Depression Scale (CES-D), participants were classified as depressed (≥16), subsydromally depressed (8-15), or normal (&lt;8). The inflammatory markers were highly skewed and, therefore, log-transformed. Inflammatory markers with subsyndromal and depression groups were entered into multivariable regression model adjusting for demographic, behavioral, biological and comorbid confounders. Results. The mean age was 62.1 (SD=10.2) and 53% were women. Twenty four percent had subsyndromal depression and 13% were depressed. Thirty nine percent were Caucasian, 28% were African-American, 22% Hispanic and 12% Chinese-American. In unadjusted analyses, and compared to normals, there was a suggestion oftrend towards a significant association of subsyndromal depression with ln CRP (β=0.06 p =0.06), but not ln IL-6 (β= 0.03 p =0.18) or ln TNF (β= 0.05 p =0.23). Moreover, there was a significant association of depressed individuals with ln CRP (β= 0.06 p &lt;0.001 ) and ln IL-6 (β= 0.10 p &lt;0.001), but not for ln TNF (β= 0.05 p =0.23). After adjusting for demographics, the association of depression with ln CRP was attenuated (β= 0.00 p =0.96 ) but remained significant for ln IL-6 (β= 0.06, p =0.01 ). Final adjustment for smoking, alcohol intake, walking for exercise, as well as for BMI, lipids, glucose, blood pressure, comorbid antihypertensives and antidepressants resulted in non-significant associations of depression with ln CRP (β= -0.06, p =0.13 ) and ln IL-6 (β=0.02, p =0.45 ) . Conclusion. While there is no association between subsyndromal depression and inflammatory markers, the significant association of depression with CRP and IL-6 appears to be explained by various biological and behavioral covariates. Future studies are needed to examine the association of novel inflammatory markers with the different spectrum of mood states.
Abstract 5272: Perinatal Loss of Nkx2–5 Results in Rapid Conduction and Contraction Defects
Authors: Laura E Briggs, Morihiko Takeda, Adolfo E Cuadra, Hiroko Wakimoto, Jonathan T Lu, Kenji Yasui, Yasuhiro Ikeda, Kenneth R Chien, Hideko Kasahara
Journal: Circulation (2008)

Homeobox transcription factor Nkx2–5, highly expressed in heart, is known to be a critical factor during early embryonic cardiac development. Having previously demonstrated the persistent expression of Nkx2–5 in cardiac myocytes from the precardiac mesoderm through to the adult heart, we hypothesized that Nkx2–5 actively regulates a critical set of genes in postnatal cardiomyocytes to maintain proper cardiac function. We generated tamoxifen-inducible Nkx2–5 knockout mice that carry homozygous floxed-Nkx2–5 alleles and a heterozygous Cre-ERTM transgene under the control of CMV enhancer and chicken-beta-globin promoter. A single injection of tamoxifen into pregnant mice on gestation day 19 almost completely deleted Nkx2–5 genes, as demonstrated by Southern and Northern blotting. These mice demonstrated rapid conduction and contraction defects within 4 days of tamoxifen-injection. Conduction defect was accompanied by reduction of the cardiac voltage-gated Na+ channel pore-forming a-subunit (Nav1.5-alpha) in ventricles, the largest ion channel in the heart responsive for rapid depolarization of the action potential. In addition, Ca2+ release from the sarcoplasmic reticulum was diminished accompanied by substantial reduction in ryanodine receptor 2. Because excitation and contraction is tightly coupled in hearts, reduced handling of Na+ and Ca2+ demonstrated in Nkx2–5 knockout hearts may mutually lead to rapid conduction and contraction defects. Survival studies demonstrated that approximately 50% of Nkx2–5 knockout mice died before 3 weeks of age, and all the knockout mice that survived demonstrated conduction defects and enlarged hearts at 4 weeks of age. These defects appeared sooner and progressed more rapidly than those seen in mice with embryonic ventricular-restricted deletion of Nkx2–5, likely due to nearly complete deletion of Nkx2–5 in the entire hearts, without compensatory mechanisms during embryonic stages after loss of Nkx2–5. Our results demonstrate that Nkx2–5 is not limited to embryonic heart development; it is critical for both conduction and contraction in the perinatal heart by regulating expression of several important gene products in conduction and contraction. This research has received full or partial funding support from the American Heart Association, AHA National Center.
De medicina
Authors: 徳長 森山
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Improvement of platelet counts in steroid-unresponsive idiopathic immune thrombocytopenic purpura after short-course therapy with recombinant alpha 2b interferon [see comments]
Authors: SJ Proctor, G Jackson, P Carey, A Stark, R Finney, P Saunders, G Summerfield, D Maharaj, A Youart
Journal: Blood (1989)
Nervenkrankheiten. Die wichtigsten Kapitel für die Praxis.
Authors: Hans Curschmann
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Naissance vie et mort des maladies infectieuses.
Authors: Charles Nicolle
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Renal Amyloidosis With a Frame Shift Mutation in Fibrinogen Aα-Chain Gene Producing a Novel Amyloid Protein
Authors: Ladan Hamidi Asl, Juris J. Liepnieks, Tomoyuki Uemichi, Jean Michel Rebibou, Eve Justrabo, Dominique Droz, Christiane Mousson, Jean Marc Chalopin, Merrill D. Benson, Marc Delpech, Gilles Grateau
Journal: Blood (1997)
How To Do It: Service provision and use of anticoagulants in atrial fibrillation
Authors: C M Sudlow, H Rodgers, R A Kenny, R G Thomson
Journal: BMJ (1995)

Several large trials have shown that the risk ofstroke in patients with non-valvar atrial fibrillation is reduced by treatment with warfarin.Implementing this research evidence requires not only an under- standing of the trials' results and ofthe changes that they imply for clinicians' treatment decisions but also an appreciation of the organisation, quantity, and quality of services required to support these changes.Understanding of these implications is crucial for developing services that allow changes in practice to produce reductions in stroke incidence while minimising the risks of treatment.This article considers the developments in service provision that will probably be required to support the changes in clinical practice suggested by the trials' results.These services will be provided largely by doctors, and their development has implications for doctors in both primary and secondary care.
Abstract 8718: Increase in the Incidence of Bacterial Endocarditis Concurrent with Changes in Guidelines
Authors: Nora M Cosgrove, Sampada K Gandhi, Jerry Q Cheng, Javier Cabrera, John S Pantazopoulos, Yingzi Deng, Abel E Moreyra, John B Kostis
Journal: Circulation (2011)

Introduction: Changes in guidelines for the prevention of bacterial endocarditis (SBE) have recommended progressively less intensive antibiotic prophylaxis. However, the effect of the changes on the incidence of SBE has not been studied. Methods: Using the Myocardial Data Acquisition System (MIDAS), a statewide database including all admissions with cardiovascular disease in all non-federal hospitals in NJ, we identified 24,161 SBE admissions (ICD codes 421.0, 421.1, 421.9, 424.9) from 1994 to 2007. Age and gender adjusted incidence was computed using the 2000 Census. Results: SBE incidence showed an increase beginning in 2001. However, when SBE incidence as a reason for admission was examined (SBE as primary diagnosis, n=7,618), there was no appreciable change during the 14 year study period. On the contrary, by fitting a piecewise linear model, admissions with SBE as a secondary diagnosis in patients admitted for another condition (n=18,476) exhibited a significant increase between 2005 and 2007 (slope 115±10, p=0.0016) but no significant change between 2001 and 2005 (slope 11±5, p=0.0701) or after 2007 (slope 9±22, p=0.7660). The reason for admission of patients admitted for SBE as a secondary diagnosis included diseases of the circulatory system (31.5%), complications of surgery or fracture (11.6%), infections and parasitic diseases (15%) and diseases of the respiratory and digestive system (16.2%), other (25.7%). Sensitivity analysis indicated similar increases in the incidence of SBE as a secondary diagnosis regardless of the primary reason for admission. Conclusions: There has been an increase in age and gender adjusted SBE incidence in NJ under the study period beginning in 2002. This is due only to an increase of SBE as a secondary diagnosis, while SBE as a reason for admission remained stable. Whether this is causally related to the changes in the guidelines needs further investigation.
Smoking-Attributable Mortality, Morbidity, and Economic Costs — California, 1985
Authors: G. A. Kaplan, W. E. Wright, K. W. Kizer
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal