tbuckley/cabot-search huggingface dataset:
HIGHER ODDS OF LONG-TERM ALL-CAUSE MORTALITY WITH PERSISTENT PULMONARY HYPERTENSION AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT: A META-ANALYSIS
Authors: Sonali Sachdeva, Harshwardhan Khandait, Jenish Bhandari, Sarvesh Naik, Abdulrahman Hashem, Mahnoor Sukaina, Rupak Desai, Ankit Vyas, Akhil Jain
Journal: Journal of the American College of Cardiology (2022)
Correction: Megalin Blockade with Cilastatin Suppresses Drug-Induced Nephrotoxicity
Journal: Journal of the American Society of Nephrology (2022)

<h3>Abstract</h3> Stability of eukaryotic mRNAs is associated with their codon, amino acid, and GC content. Yet, coding sequence motifs that predictably alter mRNA stability in human cells remain poorly defined. Here, we develop a massively parallel assay to measure mRNA effects of thousands of synthetic and endogenous coding sequence motifs in human cells. We identify several families of simple dipeptide repeats whose translation triggers acute mRNA instability. Rather than individual amino acids, specific combinations of bulky and positively charged amino acids are critical for the destabilizing effects of dipeptide repeats. Remarkably, dipeptide sequences that form extended β strands <i>in silico</i> and <i>in vitro</i> drive ribosome stalling and mRNA instability <i>in vivo</i>. The resulting nascent peptide code underlies ribosome stalling and mRNA-destabilizing effects of hundreds of endogenous peptide sequences in the human proteome. Our work reveals an intrinsic role for the ribosome as a selectivity filter against the synthesis of bulky and aggregation-prone peptides.
NON-FLUOROSCOPIC DEVICE CLOSURE OF PATENT DUCTUS ARTERIOSUS IN EXTREMELY LOW BIRTH WEIGHT INFANTS
Authors: Shyam Sathanandam, Ranjit Philip, Huma Abdulmajeed, Nathan Stecchi, Ronak J. Naik, B. Rush Waller, Jason Johnson
Journal: Journal of the American College of Cardiology (2022)
Circulating MicroRNAs, Polychlorinated Biphenyls, and Environmental Liver Disease in the Anniston Community Health Survey
Authors: Matthew C. Cave, Christina M. Pinkston, Shesh N. Rai, Banrida Wahlang, Marian Pavuk, Kimberly Z. Head, Gleta K. Carswell, Gail M. Nelson, Carolyn M. Klinge, Douglas A. Bell, Linda S. Birnbaum, Brian N. Chorley
Journal: Environmental Health Perspectives (2022)

Polychlorinated biphenyl (PCB) exposures have been associated with liver injury in human cohorts, and steatohepatitis with liver necrosis in model systems. MicroRNAs (miRs) maintain cellular homeostasis and may regulate the response to environmental stress.
Mechanobiologically optimized Ti–35Nb–2Ta–3Zr improves load transduction and enhances bone remodeling in tilted dental implant therapy
Authors: Chuanyuan Mao, Weijun Yu, Min Jin, Yingchen Wang, Xiaoqing Shang, Lu Lin, Xiaoqin Zeng, Liqiang Wang, Eryi Lu
Journal: Bioactive Materials (2022)

The tilted implant with immediate function is increasingly used in clinical dental therapy for edentulous and partially edentulous patients with excessive bone resorption and the anatomic limitations in the alveolar ridge. However, peri-implant cervical bone loss can be caused by the stress shielding effect. Herein, inspired by the concept of "materiobiology", the mechanical characteristics of materials were considered along with bone biology for tilted implant design. In this study, a novel Ti-35Nb-2Ta-3Zr alloy (TNTZ) implant with low elastic modulus, high strength and favorable biocompatibility was developed. Then the human alveolar bone environment was mimicked in goat and finite element (FE) models to investigate the mechanical property and the related peri-implant bone remodeling of TNTZ compared to commonly used Ti-6Al-4V (TC4) in tilted implantation under loading condition. Next, a layer-by-layer quantitative correlation of the FE and X-ray Microscopy (XRM) analysis suggested that the TNTZ implant present better mechanobiological characteristics including improved load transduction and increased bone area in the tilted implantation model compared to TC4 implant, especially in the upper 1/3 region of peri-implant bone that is "lower stress". Finally, combining the static and dynamic parameters of bone, it was further verified that TNTZ enhanced bone remodeling in "lower stress" upper 1/3 region. This study demonstrates that TNTZ is a mechanobiological optimized tilted implant material that enhances load transduction and bone remodeling.
NOVEL SEMI-AUTOMATED TOTAL MASS RATIO IS HELPFUL IN THE DIAGNOSIS OF LEFT VENTRICULAR NON-COMPACTION CARDIOMYOPATHY IN CHILDREN
Authors: Hanna J. Tadros, Tam Doan, Prakash Masand, Amol Pednekar, Joseph Spinner, Tobias R. Schlingmann, Ricardo Pignatelli, Cory V. Noel, James Wilkinson
Journal: Journal of the American College of Cardiology (2022)
PREDICTORS OF DISCREPANCY BETWEEN FRACTIONAL FLOW RESERVE (FFR) AND DIASTOLIC PRESSURE RATIO (DPR) IN INTERMEDIATE LESIONS - PREDICT STUDY
Authors: Alessandra Scoccia, Tara Neleman, Eric Boersma, Jurgen M.R. Ligthart, Wijnand den Dekker, Roberto Diletti, Jeroen Wilschut, Felix Zijlstra, Nicolas M. Van Mieghem, Joost Daemen
Journal: Journal of the American College of Cardiology (2022)
ASSOCIATIONS OF SYNTAX SCORES AND ONE-YEAR MORTALITY RATES FROM A LARGE TERTIARY HEART TEAM
Authors: Amy Rechenberg, Connor C. Kerndt, John J. Mulder, Stacie Vanoosterhout, Jessica Parker, DeeAnn Stickland, Richard F. McNamara, Ryan Madder, Stefan Jovinge, David McNamara
Journal: Journal of the American College of Cardiology (2022)
IMPACT OF COVID-19 VACCINATION AFTER ORTHOTOPIC HEART TRANSPLANTATION
Authors: Ahmed Noor, Saima Shikari, Nakeya Dewaswala, Josue Villegas-Galaviz, Huzefa Bhopalwala, Andrew Kolodziej, Emma Birks, Navin Rajagopalan, Gaurang N. Vaidya
Journal: Journal of the American College of Cardiology (2022)
Valoctocogene Roxaparvovec Gene Therapy for Hemophilia A
Authors: Margareth C. Ozelo, Johnny Mahlangu, K. John Pasi, Adam Giermasz, Andrew D. Leavitt, Michael Laffan, Emily Symington, Doris V. Quon, Jiaan-Der Wang, Kathelijne Peerlinck, Steven W. Pipe, Bella Madan, Nigel S. Key, Glenn F. Pierce, Brian O’Mahony, Radoslaw Kaczmarek, Joshua Henshaw, Adebayo Lawal, Kala Jayaram, Mei Huang, Xinqun Yang, Wing Y. Wong, Benjamin Kim
Journal: New England Journal of Medicine (2022)

Valoctocogene roxaparvovec (AAV5-hFVIII-SQ) is an adeno-associated virus 5 (AAV5)–based gene-therapy vector containing a coagulation factor VIII complementary DNA driven by a liver-selective promoter. The efficacy and safety of the therapy were previously evaluated in men with severe hemophilia A in a phase 1–2 dose-escalation study.
Abstract MS1-1: CRISPR screens to identify novel DNA repair defects synthetic lethal therapies
Authors: D Durocher
Journal: Cancer Research (2022)

Abstract The orchestration of DNA repair is of fundamental importance to the maintenance of genomic integrity and tumor suppression. DNA damage must be detected in the context of the varied chromatin landscape, its presence must be communicated throughout the cell to alter many ongoing processes, and the machinery that will mend the lesion must be recruited to the damage site. In my presentation, I will discuss our recent efforts in mapping genome maintenance pathways using genome-scale CRISPR/Cas9 screens in human cells. I will highlight how these screens can also identify potentially actionable synthetic lethal genetic interactions that could form the basis of new oncology drug discovery efforts. I will focus particularly on our efforts to uncover and characterize the synthetic lethal interaction network surrounding BRCA1 and BRCA2 deficiency, as well as our work that led to the discovery that inhibition of the PKMYT1 kinase is lethal in cells with amplification in the cyclin E-coding gene, CCNE1. Citation Format: D Durocher. CRISPR screens to identify novel DNA repair defects synthetic lethal therapies [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr MS1-1.
A NOVEL ANATOMICAL CHARACTERIZATION OF CAVOTRICUSPID ISTHMUS USING INTRACARDIAC ECHO IN PATIENTS UNDERGOING ATRIAL FLUTTER ABLATION: THE LETR CLASSIFICATION
Authors: Adnan Ahmed, Rishi Ajeet Charate, Jalaj Garg, Naga Venkata K. Pothineni, Mohit Turagam, Sharan Sharma, Luigi Di Biase, Rodney P. Horton, Amin Al-Ahmad, Vijay Swarup, Alap P. Shah, Sanghamitra Mohanty, Jie Cheng, Andrea Natale, Minglong Chen, Dale Yoo, Rakesh Gopinathannair, Dhanunjaya R. Lakkireddy
Journal: Journal of the American College of Cardiology (2022)
Disproportional signal of sexual dysfunction reports associated with finasteride use in young men with androgenetic alopecia: A pharmacovigilance analysis of VigiBase
Authors: David-Dan Nguyen, Peter Herzog, Eugene B. Cone, Muhieddine Labban, Kevin C. Zorn, Bilal Chughtai, Shehzad Basaria, Dean S. Elterman, Quoc-Dien Trinh, Naeem Bhojani
Journal: Journal of the American Academy of Dermatology (2022)
UTILIZATION OF INTRAVASCULAR LITHOTRIPSY IN RENAL ARTERY ANGIOPLASTY
Authors: Rakushumimarika Harada, Ammar F. ELJack, Pouyan Daniel Arman, Karim Al-Azizi, Srinivasa P. Potluri, Molly Szerlip, Sameh Sayfo, Chadi Dib
Journal: Journal of the American College of Cardiology (2022)
Transmission of SARS-CoV-2 by children and young people in households and schools: A meta-analysis of population-based and contact-tracing studies
Authors: Russell Viner, Claire Waddington, Oliver Mytton, Robert Booy, Joana Cruz, Joseph Ward, Shamez Ladhani, Jasmina Panovska-Griffiths, Chris Bonell, G.J. Melendez-Torres
Journal: Journal of Infection (2021)
SERIAL TRENDS IN UNDERUTILIZATION OF IMPLANTABLE CARDIOVERTER DEFIBRILLATOR IN HYPERTROPHIC CARDIOMYOPATHY: 2002 TO 2018
Authors: Waqas Ullah, Sameer Saleem, Salman Zahid, Arnav Kumar, Sundas Younas, Behzad B. Pavri, David L. Fischman
Journal: Journal of the American College of Cardiology (2022)
COMBINING VA-ECMO AND IMPELLA (EC-PELLA) BEFORE REPERFUSION MITIGATES LEFT VENTRICULAR INJURY DUE TO VA-ECMO IN ACUTE MYOCARDIAL INFARCTION
Authors: Kay Everett, Lija Swain, Reyelt Lara, Monica Majumdar, Xiaoying Qiao, Shreyas Bhave, Mary Warner, Elena Mahmoudi, Will Surks, Tejasvi Aryaputra, Siya Goel, Navin Kapur
Journal: Journal of the American College of Cardiology (2022)
Screening for Atrial Fibrillation in Older Adults at Primary Care Visits: VITAL-AF Randomized Controlled Trial
Authors: Steven A. Lubitz, Steven J. Atlas, Jeffrey M. Ashburner, Ana T. Trisini Lipsanopoulos, Leila H. Borowsky, Wyliena Guan, Shaan Khurshid, Patrick T. Ellinor, Yuchiao Chang, David D. McManus, Daniel E. Singer
Journal: Circulation (2022)

Background: Undiagnosed atrial fibrillation (AF) may cause preventable strokes. Guidelines differ regarding AF screening recommendations. We tested whether point-of-care screening with a handheld single-lead ECG at primary care practice visits increases diagnoses of AF. Methods: We randomized 16 primary care clinics 1:1 to AF screening using a handheld single-lead ECG (AliveCor KardiaMobile) during vital sign assessments, or usual care. Patients included were ages ≥65 years. Screening results were provided to primary care clinicians at the encounter. All confirmatory diagnostic testing and treatment decisions were made by the primary care clinician. New AF diagnoses during the 1-year follow-up were ascertained electronically and manually adjudicated. Proportions and incidence rates were calculated. Effect heterogeneity was assessed. Results: Of 30 715 patients without prevalent AF (n=15 393 screening [91% screened], n=15 322 control), 1.72% of individuals in the screening group had new AF diagnosed at 1 year versus 1.59% in the control group (risk difference, 0.13% [95% CI, –0.16 to 0.42]; P =0.38). In prespecified subgroup analyses, new AF diagnoses in the screening and control groups were greater among those aged ≥85 years (5.56% versus 3.76%, respectively; risk difference, 1.80% [95% CI, 0.18 to 3.30]). The difference in newly diagnosed AF between the screening period and the previous year was marginally greater in the screening versus control group (0.32% versus –0.12%; risk difference, 0.43% [95% CI, –0.01 to 0.84]). The proportion of individuals with newly diagnosed AF who were initiated on oral anticoagulants was not different in the screening (n=194, 73.5%) and control (n=172, 70.8%) arms (risk difference, 2.7% [95% CI, –5.5 to 10.4]). Conclusions: Screening for AF using a single-lead ECG at primary care visits did not affect new AF diagnoses among all individuals aged 65 years or older compared with usual care. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT03515057.
IMPACT OF FRAILTY ON OUTCOMES IN PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION: A META-ANALYSIS
Authors: Azka Latif, Ahsan Muhammad Junaid, Soban Ahmad, Noman Lateef, Waiel Abusnina, Jolanta Jolanta Siller-Matula, Mamas A. Mamas, Emmanouil S. Brilakis, J. Dawn Abbott, Deepak L. Bhatt, Poonam Velagapudi
Journal: Journal of the American College of Cardiology (2022)
NOT AN ORDINARY LIPOMATOUS ATRIAL SEPTAL HYPERTROPHY, OBSTACLE TO ABLATION
Authors: Ana Inashvili, David Goldgrab, Ruifang Yang, Benjamin Kilpatrick, Devansh Patel, William Bugni, Tehreen Khan, Carlos Leche, Juna Misiri, Stephen W. Mester
Journal: Journal of the American College of Cardiology (2022)
SAME-DAY DISCHARGE FOR TRANSVENOUS LEAD EXTRACTION
Authors: Akash P. Patel, Mohanad Elchouemi, Carola Gianni, Domenico Giovanni Della Rocca, Sanghamitra Mohanty, Mohamed Bassiouny, Paul R. Coffeen, Andrea Natale, Robert C. Canby, Amin Al-Ahmad
Journal: Journal of the American College of Cardiology (2022)
Determinants of SARS-CoV-2 waning immunity in allogeneic hematopoietic stem cell transplant recipients
Authors: Mathieu Leclerc, Rabah Redjoul, Anne Le Bouter, Florence Beckerich, Christine Robin, Vincent Parinet, Cécile Pautas, Dehbia Menouche, Selwa Bouledroua, Lydia Roy, Ludovic Cabanne, Yakout Nait-Sidenas, Slim Fourati, Sébastien Maury
Journal: Journal of Hematology & Oncology (2022)

Hematopoietic stem cell transplant (HSCT) recipients are at high-risk for severe COVID-19 and have altered immune responses to vaccination. We sought to evaluate the dynamics of immune response to BNT162b2 mRNA vaccine in HSCT recipients. We systematically proposed vaccination with BNT162b2 to HSCT recipients and gave a third vaccine dose to those showing titers of IgG(S-RBD) below 4160 AU/mL 1 month following the second dose. We then quantified anti-SARS-CoV-2 antibodies dynamics in 133 of these HSCT recipients (88 after two and 45 after three vaccine doses) 6 months after the first vaccine dose. Mean IgG(S-RBD) titer at 6 months was significantly lower than the peak value measured 1 month after a second (p < 0.001) or third (p < 0.01) vaccine dose. IgG(S-RBD) titers at 6 months were strongly correlated to peak values (p < 0.001) and a peak titer above 10,370 AU/mL predicted persistent protection at 6 months. Seventy-two percent (96/133) of patients retained protective antibody levels at 6 months. Immunosuppressive drugs and low lymphocyte counts in peripheral blood correlated with lower IgG(S-RBD) titers at 6 months. Four patients (3%) developed PCR-documented SARS-CoV-2 infection and one died.
ARTIFICIAL INTELLIGENCE FOR PERIPHERAL ARTERY DISEASE DETECTION USING ARTERIAL DOPPLER WAVEFORM ANALYSIS
Authors: Robert D. McBane, Dennis Murphree, David Liedl, Francisco Lopez-Jimenez, Itzhak Zachi Attia, Adelaide Arruda-Olson, Christopher Scott, Naresh Prodduturi, Steve Nowakowski, Thom W. Rooke, Ana Isabel Casanegra, Waldemar E. Wysokinski, Keith Swanson, Damon E. Houghton, Haraldur Bjarnason, Paul W. Wennberg
Journal: Journal of the American College of Cardiology (2022)
Use of Irradiated Red Blood Cell Transfusions in Newborns to Improve Intracerebral Saturation
Authors: Haresh Murli Kirpalani, Oksana Prokopchuk-Gauk, Nancy M. Heddle
Journal: JAMA Pediatrics (2022)

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STRATIFICATION OF MINORITY PARTICIPATION IN VALVULAR HEART DISEASE CLINICAL TRIALS THROUGHOUT OREGON
Authors: Zoe S. Kilmer, LilyAna C. Folk, Jasmine A. Garg, Firas E. Zahr, Scott M. Chadderdon, Howard K. Song, Harsh Golwala, Gurion Lantz
Journal: Journal of the American College of Cardiology (2022)
CARDIOVASCULAR EVENTS AND MORTALITY FOLLOWING CAR-T THERAPY- A POOLED ANALYSIS OF RANDOMIZED CONTROLLED TRIALS AND OBSERVATIONAL STUDIES
Authors: Akhil Jain, Rupak Desai, Sonali Sachdeva, Bohdan Baralo, Mimoza Isufi, Puneet Kumar Gupta
Journal: Journal of the American College of Cardiology (2022)
Errors in Table and Abstract
Journal: JAMA Network Open (2022)

Chanjira Satukijchai, MD; Romina Mariano, DPhil; Silvia Messina, MD; Mario Sa, MD; Mark R. Woodhall, PhD; Neil P. Robertson, MD; Lim Ming, MD, PhD; Evangeline Wassmer, MD; Rachel Kneen, MD; Saif Huda, DPhil; Anu Jacob, DM; Camilla Blain, MD; Christopher Halfpenny, PhD; Cheryl Hemingway, MD; Eoin O'Sullivan, MD; Jeremy Hobart, MD; Leonora K. Fisniku, PhD; Roswell Martin, MD; Ruth Dopson, MD; Sarah A. Cooper, MD; Victoria Williams, MD; Patrick J. Waters, PhD; Sithara Ramdas, MD; Maria Isabel Leite, MD, DPhil; Jacqueline Palace, DM
BRIDGE THE BAD CONNECTION: ROLE OF MULTIMODALITY IMAGING-GUIDED EVALUATION AND MANAGEMENT OF CORONARY ARTERY FISTULA AND GIANT CORONARY ARTERY ANEURYSM
Authors: Raghav Gattani, Shahrad Shadman, Hooman Bakhshi, Xiaoxiao Qian, Araba Ofosu-Somuah, Balbir S. Sidhu, Abbas Emaminia, Ramesh Singh
Journal: Journal of the American College of Cardiology (2022)
HiCBin: binning metagenomic contigs and recovering metagenome-assembled genomes using Hi-C contact maps
Authors: Yuxuan Du, Fengzhu Sun
Journal: Genome biology (2022)

Recovering high-quality metagenome-assembled genomes (MAGs) from complex microbial ecosystems remains challenging. Recently, high-throughput chromosome conformation capture (Hi-C) has been applied to simultaneously study multiple genomes in natural microbial communities. We develop HiCBin, a novel open-source pipeline, to resolve high-quality MAGs utilizing Hi-C contact maps. HiCBin employs the HiCzin normalization method and the Leiden clustering algorithm and includes the spurious contact detection into binning pipelines for the first time. HiCBin is validated on one synthetic and two real metagenomic samples and is shown to outperform the existing Hi-C-based binning methods. HiCBin is available at https://github.com/dyxstat/HiCBin .
Association of Longitudinal Trajectories of Insulin Resistance With Adverse Renal Outcomes
Authors: Seokhun Yang, Soongu Kwak, You-Hyun Song, Seung Seok Han, Hye Sun Lee, Shinae Kang, Seung-Pyo Lee
Journal: Diabetes Care (2022)

OBJECTIVE To analyze the relationship between time-serial changes in insulin resistance and renal outcomes. RESEARCH DESIGN AND METHODS A prospective cohort of subjects from the general population without chronic kidney disease (CKD) underwent a biennial checkup for 12 years (n = 5,347). The 12-year duration was divided into a 6-year exposure period, where distinct HOMA for insulin resistance (HOMA-IR) trajectories were identified using latent variable mixture modeling, followed by a 6-year event accrual period, from which the renal outcome data were analyzed. The primary end point was adverse renal outcomes, defined as a composite of estimated glomerular filtration rate (eGFR) &amp;lt;60 mL/min/1.73 m2 in two or more consecutive checkups or albumin ≥1+ on urine strip. RESULTS Two distinct groups of HOMA-IR trajectories were identified during the exposure period: stable (n = 4,770) and increasing (n = 577). During the event accrual period, 449 patients (8.4%) developed adverse renal outcomes, and the risk was higher in the increasing HOMA-IR trajectory group than in the stable group (hazard ratio 2.06, 95% CI 1.62–2.60, P &amp;lt; 0.001). The results were similar after adjustment for baseline clinical characteristics, comorbidities, anthropometric and laboratory findings, eGFR, and HOMA-IR. The clinical significance of increasing HOMA-IR trajectory was similar in three or four HOMA-IR trajectories. The increasing tendency of HOMA-IR was persistently associated with a higher incidence of adverse renal outcomes, irrespective of the prevalence of diabetes. CONCLUSIONS An increasing tendency of insulin resistance was associated with a higher risk of adverse renal outcomes. Time-serial tracking of insulin resistance may help identify patients at high risk for CKD.
Levels of beta-D-glucan in Candida auris supernatants, an in vitro and in vivo preliminary study
Authors: Malgorzata Mikulska, Elisa Furfaro, Laura Magnasco, Giulia Codda, Daniele Roberto Giacobbe, Chiara Dentone, Antonio Vena, Anna Marchese, Matteo Bassetti
Journal: Clinical Microbiology and Infection (2022)
RADIO-OPAQUE LANDMARK-BASED TARGETING TO GUIDE NON-INVASIVE RADIO-ABLATION OF VENTRICULAR TACHYCARDIA
Authors: Lucas Keyt, Todd Atwood, Andrew Bruggeman, Kevin Moore, Elliot McVeigh, Frederick Han, Jonathan C. Hsu, Kurt Hoffmayer, Ulrika Birgersdotter-Green, Gregory Feld, David Krummen, Gordon Ho
Journal: Journal of the American College of Cardiology (2022)
Spatial transcriptomic reconstruction of the mouse olfactory glomerular map suggests principles of odor processing
Authors: I-Hao Wang, Evan Murray, Greg Andrews, Hao-Ching Jiang, Sung Jin Park, Elisa Donnard, Violeta Durán-Laforet, Daniel M. Bear, Travis E. Faust, Manuel Garber, Christina E. Baer, Dorothy P. Schafer, Zhiping Weng, Fei Chen, Evan Z. Macosko, Paul L. Greer
Journal: Nature Neuroscience (2022)