tbuckley/cabot-search huggingface dataset:
Abstract 2544: Overexpression of the Polo-like kinase 4 (PLK4) contribute to tumor metastasis
Authors: Yeung Sai Fung, Yick Pang Ching
Journal: Cancer Research (2019)

Abstract The Polo-like kinase 4 (PLK4) is an important mitotic kinase that lies at the head of centriole duplication pathway. Aberration of PLK4's level in cancer cell often results in supernumery centrosome. PLK4 transcripts was upregulated in a number of cancers including breast, colon gastric and lung cancer, and PLK4 overexpression had been linked to chemoresistance and cancer metastasis. In our preliminary data, knocking down PLK4 in 97L and HLE Hepatocellular Carcinoma (HCC) cell reduced their migration and growth rate. Overexpression of PLK4 in well-differentiated hepatoma HepG2 and Huh7 cell showed enhancement in migration. Centrinone B, a highly potent PLK4 inhibitor, inhibits HCC cells' colony-forming ability and wound healing rate. To gain the insight into the mechanism how PLK4 contribute to cell migration, microtubule regrowth assay was carried out. The results indicating that PLK4 overexpressing cell had a higher rate of microtubule nucleation, which could contribute to directional movement of the cell. Further supporting that PLK4 contribute to HCC progression, we look into the clinical samples. Using qRT-PCR, we found PLK4 transcript is upregulated in a local cohort of HCC samples (n=48), we also confirmed that PLK4 is upregulated in the TCGA and two GEO available datasets. Data from the cancer dependency map showed PLK4 is a common essential gene in a panel of HCC cell line. Suggesting targeted therapy against PLK4 might be useful in reducing tumor growth or metastasis. Citation Format: Yeung Sai Fung, Yick Pang Ching. Overexpression of the Polo-like kinase 4 (PLK4) contribute to tumor metastasis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2544.
JAMA Reference Directories
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An analysis of the potential impact of health maintenance organizations upon the practice of dermatology (with recommendations)
Authors: Ronald Savin, Eugene Schoch, Alan Schragger, William Turner, Maria Turner, Milton Robin, Peyton Weary, Joel Barkoff, David Cram, San Francisco, Harry Katz, Ronald Lubritz, Franklin Pass, E Rosenberg
Journal: Journal of the American Academy of Dermatology (1980)
Hypertension Detection and Follow-up-Reply
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>Erratum</i>: Vol. 65, No. 18 Interim Guidance for Zika Virus Testing of Urine — United States, 2016
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

In the report, "Interim Guidance for Zika Virus Testing of Urine - United States, 2016," the second sentence of the second paragraph should have read, "Zika virus rRT-PCR testing of urine should be performed in conjunction with serum testing (8)." The report was first published online as an Early Release on May 10, 2016, and is now contained in this regular May 13 issue.
TRACHELOPLASTY.
Authors: HENRY PARKER NEWMAN
Journal: JAMA (1901)

<h3>The Normal and Pathologic Significance of the Cervix Uteri.</h3> —Thirty years of progress and research in modical science have not shaken materially the theory of Montrose Pallen, who, in 1867, in a prize essay read before theAmerican Medical Association, enunciated these propositions: 1. Menstruation, irregular in its character, is always coincident with uterine disease. 2. All uterine abnormalities tend to a deformity of the organ, either in its neck or in its body, or in both. "The healthy functioning of any organism necessitates a healthy condition for its performance," and, "no unhealthy cause can produce healthy effects; therefore, from a uterus abnormal can no healthy menstrual flux proceed;" and whereas he later qualified these statements by saying that "irregular menstruation may depend upon systemic causes wherein the uterine disease is but functional and symptomatic," we ourselves know that these are the exceptions and that the great majority of our
EPIDEMIC (LETHARGIC) ENCEPHALITIS AND ALLIED CONDITIONS
Authors: SIMON FLEXNER
Journal: JAMA (1923)

<h3>EXPERIMENTS IN TRANSMITTING ENCEPHALITIS TO ANIMALS</h3> Early in the epidemic outbreak of encephalitis, Dr. Amoss and I undertook the transmission of the disease to animals. The first inoculations performed in the winter of 1919 were made with emulsion of human brain into<i>Macacus rhesus</i>monkeys. Materials injected from several fatal cases were without positive result. The effort to secure transmission was continued as opportunity offered, and following the publication of the Mount Sinai experiments, to the materials previously employed for inoculation were added filtered nasopharyngeal washings, filtered extracts of nasopharyngeal mucosa, and cerebrospinal fluid; and the rabbit was substituted for the monkey, as constituting a more susceptible animal species. These attempts, continued through 1920, 1921 and 1922, failed consistently to yield an unequivocal result. Now and again an encephalitis or a meningitis would follow on the intracerebral inoculation of rabbits, but they proved, on close study, to be accidental or
Editorial Board
Authors: Stephen Mcleod, San Francisco, Daniel Albert, George Bartley, Creig Hoyt, Andrew Schachat, Anita Agarwal, Ike Ahmed, Canada Aung, Wiley Chambers, Balwantray Chauhan, Emily Chew, Michael Chiang, Mary Cotch, Marjan Farid, Lynn Gordon
Journal: Ophthalmology (2018)
Psychological Examinations of College Students.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Editor of The Journal of the American Medical Association, Chicago.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Public Workshop on Prescription Drug Information for Patients
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial Board
Authors: Shbana Rahman, Milena Nuti, Patrick Wilken, Katja Brose, Ellie Carr, Jessica Jones, Lara Crow, Matt Mccutcheon, Philip Patenall, Neill Sharp, R Adolphs, R Baillargeon, D Chalmers, N Chater, J Cohen, A Engel, R French, A Friederici, M Goodale, M Hauser, R Jackendoff, S Kosslyn, N Logothetis, J Mcclelland, L Nadel, U Arizona, Usa Pinker, Z Pylyshyn, T Robbins, S Shamma, A Wagner, V Walsh, D Wolpert
Journal: Trends in Cognitive Sciences (2008)
Vaccines Today
Authors: Aaron Levin
Journal: Annals of Internal Medicine (2000)

Current Clinical Issues17 October 2000Vaccines TodayAaron LevinAaron LevinSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-8-200010170-00102 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In 20th-century medicine, vaccines helped to alleviate an enormous burden of disease. Cases of childhood illnesses that were once common in the United States have been reduced by two orders of magnitude. Before the introduction of a vaccine for measles, an average of 500 000 cases of measles were reported annually from 1958 to 1962; only 89 cases were diagnosed in 1998. Wild-type polio has been eliminated from the western hemisphere, and smallpox has been eliminated from the globe. New vaccines to combat varicella and pneumococcal infections in infants have recently been approved, and others are in clinical trials. An ... Author, Article, and Disclosure InformationAuthors: Aaron Levin PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVaccinesSafety evaluation in mice of the childhood immunization vaccines from two south-eastern states of NigeriaBenzodiazepine inhibitors of the MMPs and TACE. Part 2Vaccines and VaccinationEffect of rotavirus vaccination programme on trends in admission of infants to hospital for intussusceptionVaccines 17 October 2000Volume 133, Issue 8Page: 661KeywordsAntigensChildrenInfectious diseasesMalariaMeaslesPertussis vaccinePoliomyelitisPregnancyRotavirusVaccines ePublished: 17 October 2000 Issue Published: 17 October 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.Loading ...
Genetic Factors in Hashimoto's Struma
Authors: R VOLPE, C EZRIN, M W JOHNSTON, J W STEINER
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Are Beta-1–Blockers Safe for Patients with Lung Disease?
Journal: Annals of Internal Medicine (2002)

Summaries for Patients5 November 2002Are Beta-1–Blockers Safe for Patients with Lung Disease?Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-9-200211050-00002 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Doctors use β-blocker drugs to treat many conditions, including high blood pressure, chest pain (angina), heart attacks, and migraine headaches. There are several types of β-blockers. Cardioselective β-blockers (β-1–blockers) act mainly on the heart. They slow heart rate, decrease blood pressure, and reduce the heart's workload. Other β-blockers act on the heart but also may narrow blood vessels throughout the body and the airways to the lungs (bronchi).Doctors often avoid β-blockers in patients with lung diseases such as asthma. They worry that the drugs will narrow airways ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Cardioselective β-Blockers in Patients with Reactive Airway Disease: A Meta-Analysis.” It is in the 5 November 2002 issue of Annals of Internal Medicine (volume 137, pages 715-725). The authors are SR Salpeter, TM Ormiston, and EE Salpeter.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCardioselective β-Blockers in Patients with Reactive Airway Disease Shelley R. Salpeter , Thomas M. Ormiston , and Edwin E. Salpeter Metrics 5 November 2002Volume 137, Issue 9Page: I-31KeywordsAsthmaDrugsForced expiratory volume in the first second of expirationHeartHeart rateLungsMigraineMyocardial infarctionPrimary hypertensionRandomized trials ePublished: 5 November 2002 Issue Published: 5 November 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Estimated cost of anticancer therapy directed by comprehensive genomic profiling (CGP) in a single-center study.
Authors: James Signorovitch, Filip Janku, Jennifer J. Wheler, Vincent A. Miller, Jason Ryan, Zhou Zhou, Anita Chawla
Journal: Journal of Clinical Oncology (2017)

6605 Background: Accumulating evidence supports the clinical benefit of targeted therapies matched to cancer patients based on genomic alterations. CGP, which detects all classes of alterations (base pair substitutions, copy number, insertions/deletions, and rearrangements), can match more patients with available and investigational therapies. This study estimated anti-cancer drug costs and overall survival (OS) for matched vs. unmatched therapy. Methods: Costs were estimated for patients with complete data (N = 188/500) from a prospective, nonrandomized, phase I oncology center study of patients with diverse refractory cancers who underwent CGP and were treated with matched or unmatched therapy (PMID: 27197177). Average time to treatment failure and average OS were assessed during the observation period. Patient-specific drug and administration costs were imputed for the first regimen after CGP based on drug classes, unit costs, and times to treatment failure. Results: Patients onmatched (N = 122) vs. unmatched (N = 66) therapy had, on average, longer time on treatment (+1.5 mos), longer observed survival (+2.4 mos), and higher anti-cancer drug costs (+$38K) (all p &lt; 0.01); 66% of increased drug costs were attributable to longer time on treatment as opposed to higher monthly drug costs. Combination therapy was used for 71% of matched and 53% of unmatched patients. Those undergoing CGP in earlier-line (1-3; N = 58) vs. later-line (4+; N = 130) therapy had numerically larger incremental increases in average times on treatment (+1.9 vs. +1.2 mos) and survival (+2.5 vs. +2.1 mos), and numerically lower incremental drug costs (+$27K vs. +$43K), with matched vs. unmatched therapy. Conclusions: For patients cared for in a phase I clinic, matched vs. unmatched therapy was associated with longer treatment durations, longer survival times, and manageable incremental costs. Despite frequent use of combination therapy, most of the increased costs of matched therapy were due to longer treatment times rather than higher monthly drug costs. Benefits of matching were numerically greater in earlier- vs. later-lines, consistent with the value of earlier-line use of CGP to guide treatment.
Intrathoracic Sarcoidosis
Authors: J R Muñoz, A Portoles, C Rubin de Celis, J Sánchez, J de Juan, A Hernández, L Placer, M Giralt, G García Julián
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HELLO, DR. CHIPS
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal