tbuckley/cabot-search huggingface dataset:
No correlation between gallstones and serum apolipoproteins A-1 and B S Morán, M Ramos, I Cruzgonzalez, A Sandoval, G de la Mora, A Martínez &amp; M.Uribe. Liver Clinic, Médica Sur Foundation and Department of Gastroenterology. Instituto Nacional de la Nutrición “Salvador Zubirán”, Mexico City, Mexico
Journal: Hepatology (1994)
More Clinical Sonnets
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Efficacy of HD201 vs Referent Trastuzumab in Patients With ERBB2-Positive Breast Cancer Treated in the Neoadjuvant Setting
Authors: Xavier Pivot, M. A. Georgievich, Volodymyr Shamrai, Giorgi Dzagnidze, Hwoei Fen Soo Hoo, Viriya Kaewkangsadan, Fausto Petrelli, Cristian Villanueva, Lipatov O. Nikolaevich, Jocelyn Hii, Jamie Kim, Sumita Pradhan, Litha Jaison, Peggy Feyaerts, Leonard Kaufman, Marie-Paule Derde, Ghislain M. C. Bonamy, Filip Deforce, David G. Cox
Journal: JAMA Oncology (2022)

The drug HD201 is a biosimilar candidate for breast cancer treatment as the reference trastuzumab.
British Association for the Study of the Liver
Authors: M Ellul, Suzanne Sequeira, G Parkes, G Murphy, Gastroenterology Unit, R Joplin, L Wallace, J Neuberger
Journal: Gut (1994)

Cholesterol (CH) is thought to deposit from unstable cholesterol-phospholipid vesicles (CH-PL) in bile.Conventional methods, however, to separate biliary vesicles from mixed PL-CH bile acid micelles are unreliable.We (a) studied the effect ofCH on 'H NMR spectra ofvesicles, (b) determined biliary PL by integration of 'H NMR spectra and enzymatic measurement (choline oxidase), (c) compared the results with the nucleation time (time taken to detect cholesterol microcrystals in the biliary iso- tropic phase).Small unilamellar CH/PL vesicles were pre- pared in TRIS buffer in mM ratios of CH:PL (5:5, 5:10, 5:15).Bile was obtained from 10 patients at cholecystectomy.'H NMR spectra were obtained on a JEOL GSX500 NMR spectrometer operating at 500 MHz and 11-5 Tesla at 37°C.PL peaks at 1-25 ppm (CH2 tail) and at 3-25 ppm (N(CH3)3) were broad at equimolar con- centrations of CH and PL but became sharper with a decreasing vesicular CH:PL ratio.There was a strong correlation (p<0-001) between the concentration of PL as measured by (N(CH3)3) peak integration and the enzymatic method.The quantitative difference between the biliary PL determined from the integration of the 'H NMR (N)CH3)3) PL and that measured enzy- matically ranged from 0-21-8% (n=5, mean= 8-4%) in biles with nucleation time >10 days and 29-5-55 2% (n=5, mean=39-5%) in biles with nucleation time <5 days.It is concluded that molecular motions of biliary PL and their detection by 'H NMR are restricted by saturation of vesicles with CH.The difference between the total biliary PL and that measured by integration of the N(CH3)3 resonance peak gives direct non-invasive sup- port for the hypothesis that the cholesterol in gall stones is deposited from vesicles with C:PL >1-0.
Enhanced protein isoform characterization through long-read proteogenomics
Authors: Rachel M. Miller, Ben T. Jordan, Madison M. Mehlferber, Erin D. Jeffery, Christina Chatzipantsiou, Simi Kaur, Robert J. Millikin, Yunxiang Dai, Simone Tiberi, Peter J. Castaldi, Michael R. Shortreed, Chance John Luckey, Ana Conesa, Lloyd M. Smith, Anne Deslattes Mays, Gloria M. Sheynkman
Journal: Genome biology (2022)

The detection of physiologically relevant protein isoforms encoded by the human genome is critical to biomedicine. Mass spectrometry (MS)-based proteomics is the preeminent method for protein detection, but isoform-resolved proteomic analysis relies on accurate reference databases that match the sample; neither a subset nor a superset database is ideal. Long-read RNA sequencing (e.g., PacBio or Oxford Nanopore) provides full-length transcripts which can be used to predict full-length protein isoforms.
Self-portrait
Authors: M. Therese Southgate
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genetically modified cancer vaccines: Current status and future prospects
Authors: Xiaoyi Hu, Weilin Zhou, Ruyu Pi, Xia Zhao, Wei Wang
Journal: Medicinal Research Reviews (2022)

Abstract Vaccines can stimulate the immune system to protect individuals from infectious diseases. Moreover, vaccines have also been applied to the prevention and treatment of cancers. Due to advances in genetic engineering technology, cancer vaccines could be genetically modified to increase antitumor efficacy. Various genes could be inserted into cells to boost the immune response, such as cytokines, T cell costimulatory molecules, tumor‐associated antigens, and tumor‐specific antigens. Genetically modified cancer vaccines utilize innate and adaptive immune responses to induce durable antineoplastic capacity and prevent the recurrence. This review will discuss the major approaches used to develop genetically modified cancer vaccines and explore recent advances to increase the understanding of engineered cancer vaccines.
Textbook of Gynecologic Endocrinology.
Journal: Annals of Internal Medicine (1969)

is accumulating at an ever increasing rate about one pituitary axis', deals with new concepts of the control of single protein-albeit an important one.the central nervous system over the gonadotrophic sec- VINCENT MARKS retion of the pituitary gland and gives a fascinating account of the experimental work that led to these INTERFERENCE MICROSCOPY FOR THE BIOLOGIST By S. concepts; it includes an admirably written section on Tolansky (Pp.xii + 166; 130 figures.$11.75) Spring-steroid feedback control mechanisms with an excellent ex- field, Illinois: Charles C. Thomas.1968.planatory diagram.Finally, in the subsection on pituitary A rather specialized form of interferometry (phase con-diseases, the clinical application of the physiological trast) is already well known to the biologist, but the data is discussed.commercial interference microscopes are mainly de-
Trends in Injection Drug Use Among Persons Entering Addiction Treatment--New Jersey, 1992-1999
Journal: JAMA (2001)

Injection drug use is associated with high risk for transmission of bloodborne infections, including human immunodeficiency virus (HIV) and hepatitis B and C. Since 1993, the proportion of persons admitted to New Jersey addiction treatment centers for illicit drug use who reported injecting drugs has increased, reversing a decline that began in approximately 1980 (1; Community EpidemiologyWork Group, unpublished data, 2000). This report summarizes an analysis of trends in injection drug use among persons admitted to New Jersey addiction treatment programs during 1992-1999; the findings suggest substantial increases in injection use among young adult heroin users throughout the state and an increase in heroin use among young adults who reside in suburban and rural New Jersey.
Correction: Calcific Constrictive Pericarditis
Journal: Annals of Internal Medicine (2000)

Corrections17 October 2000Correction: Calcific Constrictive PericarditisFREESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-8-200010170-00028 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The last sentence in the second paragraph on page 449 of the article on calcific constrictive pericarditis (1) should read “In their study, they used computed tomography to detect calcification.”Reference1. Ling LH, Oh JK, Breen JF, Schaff HV, Danielson GK, Mahoney DW, et al . Calcific constrictive pericarditis: is it still with us? Ann Intern Med. 2000;132:444-50. LinkGoogle Scholar Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCalcific Constrictive Pericarditis: Is It Still with Us? Lieng H. Ling , Jae K. Oh , Jerome F. Breen , Hartzell V. Schaff , Gordon K. Danielson , Douglas W. Mahoney , James B. Seward , and A. Jamil Tajik Metrics 17 October 2000Volume 133, Issue 8Page: 659KeywordsComputed axial tomography ePublished: 17 October 2000 Issue Published: 17 October 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Conference—“Mantel-Haenszel—Twenty-five Years Later”
Journal: JNCI Journal of the National Cancer Institute (1984)

Conference—“Mantel-Haenszel—Twenty-five Years Later” Get access JNCI: Journal of the National Cancer Institute, Volume 72, Issue 5, May 1984, Page 1209, https://doi.org/10.1093/jnci/72.5.1209-e Published: 01 May 1984
STRESS 'The Rate of Wear and Tear In the Human Machinery'
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Safety of Nirsevimab for RSV in Infants with Heart or Lung Disease or Prematurity
Authors: Joseph Domachowske, Shabir Madhi, Eric A.F. Simões, Victoria Atanasova, Fernando Cabañas, Kenji Furuno, Maria Garcia-Garcia, Ineta Grantina, Kim Nguyen, Dennis Brooks, Yue Chang, Amanda Leach, Therese Takas, Yuan Yuan, M. Pamela Griffin, Vaishali Mankad, Tonya Villafana
Journal: New England Journal of Medicine (2022)
Error in Figure 1
Journal: JAMA Network Open (2022)

Ian R. H. Rockett, PhD, MPH; Haomiao Jia, PhD; Bina Ali, PhD; Aniruddha Banerjee, PhD; Hilary S. Connery, MD, PhD; Kurt B. Nolte, MD; Ted Miller, PhD; Franklin M. M. White, MD, MSc; Bernard D. DiGregorio, MA; G. Luke Larkin, MD, MSPH; Steven Stack, PhD; Kairi Kõlves, PhD; R. Kathryn McHugh, PhD; Vijay O. Lulla, PhD; Jeralynn Cossman, PhD; Diego De Leo, PhD, MD; Brian Hendricks, PhD; Paul S. Nestadt, MD; James H. Berry, DO; Gail D’Onofrio, MD; Eric D. Caine, MD
Hypothermia-Related Deaths—Georgia, January 1996-December 1997, and United States, 1979-1995Outbreak of Primary and Secondary Syphilis—Guilford County, North Carolina, 1996-1997Update: Respiratory Syncytial Virus Activity—United States, 1997-98 SeasonImpact of Closure of a Sexually Transmitted Disease Clinic on Public Health Surveillance of Sexually Transmitted Diseases—Washington, D.C., 1995Hypothermia-Related Deaths—Georgia, January 1996-December 1997, and United States, 1979-1995Outbreak of …
Journal: JAMA (1999)

table, figure omittedALTHOUGH HYPOTHERMIA-RELATED deaths are prevalent during the winter in states that have moderately cold (e.g., Illinois, New York, and Pennsylvania) to severely cold (e.g., Alaska and North Dakota) winters and in states with mountainous or desert terrain (e.g., Arizona, Montana, and New Mexico), hypothermia-related deaths also occur in states with milder climates (e.g., Georgia, Mississippi, and South Carolina), where weather systems can cause rapid changes in temperature.This report summarizes three hypothermia-related deaths in Fulton County, Georgia, representing persons in the highest risk groups for hypothermia; and summarizes hypothermia-related deaths in Georgia during January
Papers and originals.
Authors: D Rogers, J Tripp, A Bentovim, A Robinson, D Berry, R Goulding
Journal: BMJ (1976)

Six cases of persistent non-accidental poisoning of children by their parents are reported. Certain features may draw attention to the diagnosis, particularly bizarre symptoms and signs with no apparent pathological explanation, and toxicological analysis should be carried out to obtain rapid confirmation of the diagnosis. The underlying disorder may include marital conflict, overinvolvement between parent and child, or drug abuse in the parents. A suggested plan of action for managing this problem is outlined.
Viral vectors expressing group B meningococcal outer membrane proteins induce strong antibody responses but fail to induce functional bactericidal activity
Authors: Leanne Marsay, Christina Dold, Gavin K. Paterson, Yuko Yamaguchi, Jeremy P. Derrick, Hannah Chan, Ian M. Feavers, Martin C.J. Maiden, David Wyllie, Adrian V. Hill, Andrew J. Pollard, Christine S. Rollier
Journal: Journal of Infection (2022)

<h2>Summary</h2><h3>Objective</h3> Adenoviral vectored vaccines, with the appropriate gene insert, induce cellular and antibody responses against viruses, parasites and intracellular pathogens such as <i>Mycobacterium tuberculosis</i>. Here we explored their capacity to induce functional antibody responses to meningococcal transmembrane outer membrane proteins. <h3>Methods</h3> Vectors expressing porin A and ferric enterobactin receptor A antigens were generated, and their immunogenicity assessed in mice using binding and bactericidal assays. <h3>Results</h3> The viral vectors expressed the bacterial proteins in an <i>in vitro</i> cell-infection assay and, after immunisation of mice, induced higher titres (>10<sup>5</sup> end-point titre) and longer lasting (>32 weeks) transgene-specific antibody responses <i>in vivo</i> than did outer membrane vesicles containing the same antigens. However, bactericidal antibodies, which are the primary surrogate of protection against meningococcus, were undetectable, despite different designs to support the presentation of the protective B-cell epitopes. <h3>Conclusion</h3> These results demonstrate that, while the transmembrane bacterial proteins expressed by the viral vector induced strong and persistent antigen-specific antibodies, this platform failed to induce bactericidal antibodies. The results suggest that conformation or post-translational modifications of bacterial outer membrane antigens produced in eukaryote cells might not result in presentation of the necessary epitopes for induction of functional antibodies.
Chiropody services.
Authors: M L Haigh
Journal: BMJ (1976)

respiratory arrest and died.No additional informa- tion was obtained at post-mortem examination.Presumably in our patient the normal blood loss from the corpus luteum was magnified by anticoagulation.Menorrhagia and irregular prolonged menstrual cycles are common in renal failure, but some of these cycles are ovulatory.1Often an oral contraceptive agent is advised to reduce the menstrual blood loss in these patients, who are already anaemic.A more simple approach would be to use medroxyprogesterone 150 mg intramuscularly three-monthly.This would prevent ovulation and conception and would perhaps abolish menstruation.There may therefore be a place for the regular use of a long-acting progester- one in some menstruating women being treated by chronic haemodialysis.
Toripalimab plus chemotherapy in treatment-naïve, advanced esophageal squamous cell carcinoma (JUPITER-06): A multi-center phase 3 trial
Authors: Zi-Xian Wang, Chengxu Cui, Jun Yao, Yanqiao Zhang, Mengxia Li, Jifeng Feng, Shujun Yang, Yun Fan, Jianhua Shi, Xizhi Zhang, Lin Shen, Yongqian Shu, Cailian Wang, Tianyang Dai, Teng Mao, Long Chen, Zengqing Guo, Bo Liu, Hongming Pan, Shundong Cang, Yi Jiang, Junye Wang, Min Ye, Zhendong Chen, Da Jiang, Qin Lin, Wei Ren, Junsheng Wang, Lin Wu, Yong Xu, Zhanhui Miao, Meili Sun, Conghua Xie, Ying Liu, Qifeng Wang, Lina Zhao, Qi Li, Canhong Huang, Ke Jiang, Kunyu Yang, Daojun Li, Yunpeng Liu, Zhitu Zhu, Rixin Chen, Liqun Jia, Wei Li, Wangjun Liao, Hong-Xu Liu, Daiyuan Ma, Jie Ma, Yanru Qin, Zhihong Shi, Qichun Wei, Ke Xiao, Yan Zhang, Ying Zhang, Xin Chen, Guanghai Dai, Jianxing He, Junhe Li, Guanghui Li, Yong Liu, Zhihua Liu, Xianglin Yuan, Junping Zhang, Zhichao Fu, Yifu He, Fang Ju, Zheng Liu, Peng Tang, Tiejun Wang, Weibo Wang, Jing Zhang, Xianming Luo, Xiongwen Tang, Rena May, Hui Feng, Sheng Yao, Patricia Keegan, Rui-Hua Xu, Feng Wang
Journal: Cancer Cell (2022)

Platinum-based chemotherapy is the standard first-line treatment for advanced esophageal squamous cell carcinoma (ESCC). In this phase 3 study (ClinicalTrial.gov: NCT03829969), 514 patients with treatment-naïve advanced ESCC were randomized (1:1) to receive toripalimab or placebo in combination with paclitaxel plus cisplatin (TP) every 3 weeks for up to 6 cycles, followed by toripalimab or placebo maintenance. At the prespecified final analysis of progression-free survival (PFS), a significant improvement in PFS is observed for the toripalimab arm over the placebo arm (hazard ratio [HR] = 0.58; 95% CI, 0.46–0.74; p < 0.0001). The prespecified interim analysis of overall survival (OS) also reveals a significant OS improvement for patients treated with toripalimab plus TP over placebo plus TP (HR = 0.58; 95% CI, 0.43–0.78; p = 0.0004). The incidences of grade ≥3 treatment-emergent adverse events are similar between the two arms. Toripalimab plus TP significantly improves PFS and OS in patients with treatment-naïve, advanced ESCC, with a manageable safety profile.
Rupture of the Coronary Sinus with Hemopericardium: Rare Complication of Coronary Arteriovenous Fistula
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bacterial meningitis presenting with a normal cerebrospinal fluid leukocyte count
Authors: Thijs M. van Soest, Nora Chekrouni, Nina M. van Sorge, Matthijs C. Brouwer, Diederik van de Beek
Journal: Journal of Infection (2022)

We describe clinical characteristics and outcome of adults with bacterial meningitis presenting with a normal CSF leukocyte count.We studied community-acquired bacterial meningitis with a normal CSF leukocyte count (≤ 5 per mm3) in adults from a prospective nationwide cohort study.From 2006 through 2020, 39 of 2,357 (2%) episodes presented with a normal CSF leukocyte count. Immunocompromising conditions were present in 19 of 39 patients (49%), compared to 690 of 2303 (30%) in patients with elevated leukocytes (P = 0.02). The triad of fever, neck stiffness, and altered consciousness was present in 6 of 34 patients (18%). CSF protein was abnormal in 25 of 37 patients (68%). We identified 3 clinical subgroups: those with severe pneumococcal meningitis (20 patients [51%]), with mainly sepsis (8 [21%]), and a miscellaneous group (11 [28%]). All patients with severe pneumococcal meningitis presented with high CSF protein levels and 18 of 19 (95%) had bacteria in the CSF Gram stain. Outcome was unfavorable in 23 of 39 (59%) patients and 12 (31%) died.Patients with bacterial meningitis may present with normal CSF leukocyte counts. In these patients, CSF protein levels and Gram staining are important diagnostic parameters.