tbuckley/cabot-search huggingface dataset:
JAPAN
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Single-Centre Retrospective Study into Diagnosis and Management of Mirizzi Syndrome Using Single-Operator Peroral Cholangioscopy
Authors: G Thomas, H Martin, G Webster
Journal: Endoscopy (2021)

Aims Mirizzi Syndrome was first described in 1948 and refers to obstruction of the bile duct by impacted gallstones in the cystic duct or gallbladder. Management with conventional ERCP is often difficult. We report our single centre experience using single-operator cholangioscopy and electrohydraulic lithotripsy.
Another Side Effect of NSAIDs
Authors: George R. Gay
Journal: JAMA (1990)

The nonsteroidal anti-inflammatory drugs (NSAIDs) have enjoyed a generally laudatory press, their acronym implying neither steroid nor narcotic mechanism of action. They encompass a heterogeneous group of compounds, mostly organic acids, that appear to owe their therapeutic efficacy to an inhibition of the biosynthesis of prostaglandins. They exhibit very real analgesic and antipyretic actions as well as being anti-inflammatory (acetaminophen and phenacetin are<i>not</i>NSAIDs, lacking anti-inflammatory action), are surely our major pharmacologic tools in the treatment of rheumatic and arthritic disorders, and as such enjoy an expanding global utilization and popularity. The NSAIDs do, however, share certain therapeutic side effects as well as benefits.<sup>1</sup>Aspirin, the prototype NSAID (available since 1898), indomethacin (for over 35 years), phenylbutazone, and other older NSAIDs have a long track record of clinical efficacy and "relative" safety. Hepatotoxicity, however, is an increasingly recognized laboratory abnormality and a rare clinical side effect of the
MEDICAL HUMOR
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Errors in Text and Tables
Journal: JAMA (2016)

Clara K. Chow, MBBS, PhD; Julie Redfern, PhD; Graham S. Hillis, MBChB, PhD; Jay Thakkar, MBBS; Karla Santo, MBBS; Maree L. Hackett, PhD; Stephen Jan, PhD; Nicholas Graves, PhD; Laura de Keizer, BSc (Nutr); Tony Barry, BSc; Severine Bompoint, BSc (Stats); Sandrine Stepien, MBiostat; Robyn Whittaker, MPH; Anthony Rodgers, MBChB, PhD; Aravinda Thiagalingam, MBChB, PhD
SYPHILIS AND CIVILIZATION.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BUENOS AIRES
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of Structure on Binding to the 2,3,7,8-TCDD Receptor Protein and AHH Induction. Halogenated Biphenyls
Authors: Stephen Safe, Stelvio Bandiera, Tom Sawyer, Bozena Zmudzka, Grant Mason, Marjorie Romkes, Mary Anne Denomme, Judy Sparling, Allan B. Okey, Toshio Fujita
Journal: Environmental Health Perspectives (1985)

The quantitative structure-activity relationships (QSARs) for polychlorinated biphenyl (PCB) congeners have been determined by comparing the ECQ, values for three in vitro test systems, namely, aryl hydro- carbon hydroxylase (AHH) and ethoxyresorufin O-deethylase (EROD) induction in rat hepatoma H-4-II- E cells and competitive binding avidities to the rat cytosolic receptor protein (using 2,3,7,8-tetrachlorodibenzo-p-dioxin as a radioligand).For several PCB congeners that are in vivo inducers of rat hepatic microsomal AHH, there was a linear correlation between the -log EC.4 values for receptor and&the -log ECso values for AHH (or EROD) induction; moreover, a comparable linear relationship was observed between the -log EC.4 values for AHH and EROD induction.Previous in vivo studies have shown that the most active PCB congeners 3,3 ',4,4'-tetra-, 3,4,4',5-tetra-, 3,3',4,4',5-penta-, and 3,3',4,4',5,5'-hexachlorobiphenyl, cause many of the biologic and toxic effects reported for the highly toxic halogenated aryl hydrocarbon, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).Moreover, the monoortho-substituted homologs of the four coplanar PCBs also elicit comparable in vivo biologic and toxic responses.It was evident from the QSARs for PCBs that there was an excellent correspondence between the in vivo and in vitro potencies of the individual PCB congeners.The effects of substituents on both receptor binding and AHH/EROD induction was determined for a series of 4'-substituted (X)-2,3,4,5-tetrachlorobiphenyls (where X = H, Cl, Br, I, OH, OCH,, NO2, COCH3, F, CF3, CH3, C2HA, i-C3H7, n-C4H, and t-C4H,).Not unexpectedly, there was a linear relationship between the -log ECso values for AHH and EROD induction, and these results confirm that both enzymatic oxidations are catalyzed by the same cytochrome P-450 isozyme(s).The effects of substituent structure on receptor binding for 12 substituents was subjected to multiple regression analysis which correlates the relative binding affinities of the compounds with the physical chemical characteristics of the substituents.The analysis gave the following equation: log (1/EC,0) = 1.53a + 1.47Th + 1.09 HB + 4.08 for n = 12, s = 0.18, r = 0.978; where n is the number of substituents, s is the standard deviation, r is the correlation coefficient, and af = electronegativity, -T = hydrophobicity (log P) and HB = hydrogen bonding capacity for the substituent groups.The data suggest that the latter three parameters facilitate the interaction between.theligand and the cytosolic receptor protein.The effects of two lateral substituents on ligandreceptor interactions are not readily explained by the above relationship and may depend on other sub- stituent physical chemical parameters.
Recurrent tetanus.
Authors: S Y Wickramasinghe, M Fernando
Journal: BMJ (1967)

the virus of foot-and-mouth disease in the course of their normal work.All samples, tested in parallel with the serum from the patient, were negative (titre less than 1/8) except for one serum from a member of staff which showed a neutralizing titre of 1/22 against virus of type 0.
Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock
Authors: Chul-Su Yang, Dong-Seok Lee, Chang-Hwa Song, Se-Jin An, Shengjin Li, Jin-Man Kim, Cuk Seong Kim, Dae Goon Yoo, Byeong Hwa Jeon, Hee-Young Yang, Tae-Hoon Lee, Zee-Won Lee, Jamel El-Benna, Dae-Yeul Yu, Eun-Kyeong Jo
Journal: The Journal of Experimental Medicine (2007)

The authors regret that an error appeared in the third paragraph under the subheading "Prx II negatively modulates NF-κB activation and the phosphorylation of MAPK pathway kinases in response to LPS."In the sentence, "lower" should have read "higher."The corrected sentence appears below:Consistent with the fi ndings in Fig. 3 C, primary BMDMs from Prx II-defi cient mice showed higher activation of MAPKs, which included JNK, ERK 1/2, and p38, than the primary BMDMs from WT mice, although the kinetics of activation during LPS treatment were similar for cells for the two types of mice (Fig. 3 D).In addition, the rule below "+ LPS" in Fig. 4 A should have extended over lane 2. The corrected fi gure is shown below.Figure 4. Endogenous ROS induced by NADPH oxidase is specifi cally involved in LPS signaling and proinfl ammatory responses in Prx II-defi cient cells.(A) After preincubation for 30 min with 10 and 30 mM NAC, 10 and 20 μM DPI, 10 and 100 μM allopurinol, 1 and 10 μM rotenone, 100 and 500 μM L-NMMA, or 100 and 500 μM L-NAME, BMDMs were stimulated with 1 μg/ml LPS for 30 min.The cells were harvested and subjected to Western blot analysis for IκBα, phosphorylated ERK 1/2, and p38 MAPK.The same blots were washed and blotted for β-actin as the loading control.Data shown are representative of three independent experiments that gave similar results.(B) The experimental conditions followed the pattern outlined in A. Culture supernatants were harvested after stimulation with LPS for 18 h, and the TNF-α and IL-6 expression levels were measured by ELISA.Data shown are the mean ± SD of three experiments.*, P < 0.05; **, P < 0.01; and ***, P < 0.001 compared with WT cell cultures stimulated with LPS.MC, media control.
BOOKS RECEIVED.
Journal: British Journal of Dermatology (1936)

British Journal of DermatologyVolume 48, Issue 12 p. 670-670 BOOKS RECEIVED. First published: December 1936 https://doi.org/10.1111/j.1365-2133.1936.tb15552.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume48, Issue12December 1936Pages 670-670 RelatedInformation
Atypical lesions of the anal mucosa in homosexual men
Authors: G. Nash
Journal: JAMA (1986)

Recent studies suggest that there is an increased incidence of squamous cell carcinoma of the anus in male homosexuals, but a precursor lesion has not been identified. We retrospectively analyzed in a blind fashion all anal tissue removed surgically during 1984. Twelve (6.7%) of the 180 specimens from men contained lesions with foci of epithelial atypia. Only one (0.85%) of 118 specimens from women harbored similar atypia. Of seven additional file cases exhibiting atypical anal mucosa, six were from men. Of 14 men with atypical anal lesions whose sexual orientation was known, 11 (79%) were homosexuals. In the 20 cases found to have atypical mucosal lesions, three patterns of atypia were identified, with more than one often occurring in the same specimen. Anal intraepithelial neoplasia (dysplasia) was identified in seven cases (35%) and occurred primarily at the anorectal junction and in anal ducts. Atypical condyloma was found in three cases ( 15%). A third lesion histologically indistinguishable from Bowen's disease or bowenoid papulosis was found in 12 cases (60%). In ten of these the lesion was adjacent to a condyloma. Although the natural history of these lesions of the anal mucosa is presently unknown, it may resemble that of similar lesions in other anatomic locations. (<i>JAMA</i>1986;256:873-876)
On the motion of blood in the veins.
Authors: None Lord Cohen of Birkenhea
Journal: BMJ (1971)

The topic I have chosen-on the motion of blood in the veins- deals specifically with the dynamic aspects of the flow of blood to the heart and relates especially to the views held in the centuries following the publication of William Harvey's De Motu Cordis (1628).That the venous system is the forgotten part of the circulation is perhaps an exaggerated statement, yet a survey of contemporary textbooks of physiology lends it support.And this is the more surprising since the demonstra- tion of the circulation owed so much to observations and experiments on the veins.Did not Robert Boyle write in 1688, "When I asked our famous Harvey ... What were the things that induc'd him to think of a Circulation of the Blood?He answer'd me, that when he took notice that the Valves in the Veins ... were so plac'd that they gave free passage to the Blood Towards the Heart, but oppos'd the passage of the Venal Blood the Contrary way: he was invited to imagine, that so Provident a Cause as Nature had not so Plac'd so many Valves without Design: and no Design seem'd more probable, than That, since the blood could not well, because of the interposing Valves, be sent by the Veins to the Limbs; it should be sent through the Arteries, and Return through the Veins, whose Valves did not oppose its course that way."It is also pertinent to interpolate that the only illustrations in De Motu Cordis are of Harvey's observa- tions on the arm veins, which show the unidirectional flow of blood to the heart.Again, in 1648, when Jean Riolan fils, regius professor of medicine, the newly appointed dean of the Faculty of Medicine in Paris, sent Harvey a copy of his Encheiridion, in which he doubted the universal application of Harvey's views to the circulation, Harvey replied the following year in two letters (1649).In the penultimate paragraph of the first letter Harvey suggested the following experiment on venous return to try to convince Riolan: "Open an animal's chest and ligate the vena
Correction
Journal: BMJ (1947)

of the Kent Branch from 1913, the year of its forma- tion, until. 1927.From 1927 to 1929 he served on the Council of the Association, and was a member of the Private Practice Committee from 1927 to 1929, and the Medico-Political Com- mittee in 1928-9.When the National Health Insurance Act of 1911 came in the South-Eastern Branch considered it wise to break up into three branches, one each for Kent, Sussex, and Surrey.Dr. Starling was largely responsible for this reorganiza- tion, and when it was completed he was presented with a massive silver rose-bowl.Before he retired from the Kent
THE REMOVAL OF GOUTY TOPHI AND URATIC CONCREMENTS.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Therapeutics, Its Principles and Practice. H. C. Wood, M.D., LL.D. Twelfth edition.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NONPENETRATING LIVER INJURY
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal