tbuckley/cabot-search huggingface dataset:
Glibenclamide, a putative ATP-sensitive K+ channel blocker, inhibits coronary autoregulation in anesthetized dogs.
Authors: TNarishige, KEgashira, YAkatsuka, YKatsuda, KNumaguchi, MSakata, ATakeshita
Journal: Circulation Research (1993)

We tested the hypothesis that ATP-sensitive K+ channels are involved in the mechanism mediating coronary autoregulation in open-chest dogs. We perfused the left anterior descending coronary artery with arterial blood from an extracorporeal circuit and measured steady-state coronary blood flow (CBF) with stepwise changes in coronary perfusion pressure (CPP) between 50 and 150 mm Hg during an intracoronary infusion of vehicle or glibenclamide (a putative blocker of ATP-sensitive K+ channels). CBF was relatively stable over CPP between 50 and 110 mm Hg during vehicle infusion, indicating the presence of autoregulation at the CPP range. During glibenclamide infusion (10 micrograms.min-1 x kg-1), CBF progressively decreased with reduction in CPP below 110 mm Hg, whereas the CPP-CBF relation at CPP above 110 mm Hg was not altered by glibenclamide. The autoregulation index [1-(delta F/F)/(delta P/P), where F indicates CBF and P indicates CPP] was greater than 0 over the CPP range between 50 and 100 mm Hg during ...
Prophylactic Endoscopic Closure After Widespread ESD/EMR (Colon Polyps ≥20MM) in the Colorectum Using the Over-the-Scope-Clip (OTSC) System. A Retrospective Study
Authors: T Blasberg, L Leifeld, C Jung, J Hochberger, E Wedi
Journal: Endoscopy (2021)

Aims This study aims to evaluate the efficacy and safety of prophylactic tissue approximation and wound reduction using the OTSC-System after complex endoscopic submucosal dissection (ESD) or endoscopic mucosal resection (EMR) of large (≥20mm) colonic and rectal superficial lesions.
Cellular mechanisms of endotoxin-induced myocardial depression in rabbits.
Authors: JHung, W YLew
Journal: Circulation Research (1993)

We investigated the mechanisms by which endotoxic shock induces intrinsic myocardial depression by studying cardiac myocytes isolated from 10 anesthetized instrumented rabbits given 172 +/- 42 (mean +/- SD) micrograms/kg IV endotoxin. Left ventricular (LV) depression developed 4 +/- 1 hours after endotoxin administration, with a 15 +/- 4% increase in LV internal end-systolic diameter, measured with sonomicrometers at a matched LV end-systolic pressure of 65 +/- 10 mm Hg. Normal LV pressure, arterial PO2, and pH were maintained to minimize confounding effects of ischemia, hypoxia, and acidosis. Cardiac myocytes from endotoxin-exposed rabbits had less unloaded cell shortening and lower peak rates of cell shortening (-dL/dt) and lengthening (+dL/dt) at [Ca2+] levels ranging from 0.5 to 16 mM when compared with myocytes isolated from normal rabbits or rabbits undergoing an identical protocol but without exposure to endotoxin. At 2 mM [Ca2+], cell shortening was depressed by approximately 25% because of a decr...
Screening for Prostate Cancer
Authors: W J Catalona
Journal: New England Journal of Medicine (1996)

In the United States, prostate cancer will affect 1 man in 6 during his lifetime.Since the mid-1980s, screening with the prostate-specific antigen (PSA) blood test has more than doubled the risk of a prostate cancer diagnosis.A decrease in prostate cancer death rates has been observed since that time, but the relative contribution of PSA testing as opposed to other factors, such as improved treatment, has been uncertain.The recent release of 2 large randomized trials suggests that if there is a benefit of screening, it is, at best, small.Methods to assess a man's risk of prostate cancer, including those tools that integrate multiple risk factors, are now available and should be used in risk assessment.Men undergoing screening for prostate cancer may reduce their risk of prostate cancer with finasteride.
Sudden death in the young. Is acute coronary thrombosis the major precipitating factor
Authors: DCorrado, CBasso, APoletti, AAngelini, MValente, GThiene
Journal: Circulation (1994)

BACKGROUNDAtherosclerotic coronary artery disease, complicated by acute thrombosis, is the usual cause of sudden death in adults. This study addresses the pathology of coronary arteries in sudden death in the young (< or = 35 years old).METHODS AND RESULTSAmong 200 consecutive cases of sudden death in youth in the Veneto region of Italy, 37 (33 men and 4 women, age 18 to 35 years; mean, 29.4 years) showed obstructive atherosclerotic coronary artery disease in the absence of other cardiac pathological conditions and causes of death. No patient had previous angina pectoris or myocardial infarction. Cardiac arrest occurred at rest in 30 subjects and was related to effort in 7. A histological study was carried out on the obstructive coronary plaques. Degree of lumen stenosis and extension of lipid core and intimal fibrocellular hyperplasia facing the lumen were calculated morphometrically. Immunohistochemistry and electron microscopy were used to further characterize the plaque cell population. Single-vessel ...
Radioiodinated soluble canine fibrin. Preparation and evaluation as a thrombus localizing agent in the dog.
Authors: R EColeman, S SHarwig, J FHarwig, L ASherman, M JWelch
Journal: Circulation Research (1975)

To develop a thrombus localizing tracer which has characteristics superior to labeled fibrinogen for external detection, we evaluated radioiodinated soluble fibrin. Labeled soluble fibrin was prepared by clotting and dissolving radioiodinated (131I) canine fibrinogen under specified conditions. Biological clearance studies revealed rapid clearance of the labeled soluble fibrin from the blood with a half-life of 5 hours. The accumulation of labeled soluble fibrin and fibrinogen in induced venous thrombi, coronary artery thrombi, and the myocardium was compared in dogs. In venous thrombi, soluble fibrin and fibrinogen exhibited maximum thrombus-blood ratios when they were injected 4 hours after thrombus induction; the thrombus-blood ratio was greater for soluble fibrin than it was for fibrinogen when these agents were injected 4, 8, or 24 hours after thrombosis induction. In induced coronary artery thrombi, soluble fibrin and fibrinogen accumulated to the same extent. Since the blood clearance of soluble fi...
The interval ejection fraction: a cineangiographic and radionuclide study.
Authors: A JKemper, J ABianco, R MShulman, E DFolland, A FParisi, D ETow
Journal: Circulation (1982)

To evaluate the clinical usefulness of the first-third ejection fraction (1/3 EF) for detecting patients with coronary artery disease (CAD), resting contrast ventriculography and first-pass radionuclide angiography with a high-count-rate, multicrystal camera system were performed in 47 subjects: 22 normal controls (group 1) and 25 patients with clinically stable angina pectoris and severe CAD (mean 2.3 vessels) without (group 2, n = 12) and with (group 3, n = 13) resting wall motion abnormalities. By contrast angiography, only group 3 had depressed global EF or 1/3 EF compared with control (global EF: group 1,0.71 +/- 0.09; group 2, 0.67 +/- 0.09 [NS]; group 3,049 +/- 0.05 [p less than 0.01 vs groups 1 and 2]; 1/3 EF: group 1,0.29% +/- 0.06;' group 2, 0.28 +/- 0.05 [NS]; group 3,0.22 +/- 0.05 [p less than 0.02 vs groups 1 and 2]). Whereas 11 of 25 CAD patients had global EF outside the normal range, only two of 25 had depressed 1/3 EF. Both had left ventricular asynergy and a depressed global EF. Studies ...
Discoid lupus erythematosus-like lesions in carriers of X-linked chronic granulomatous disease
Authors: J.H.SILLEVIS SMITT, R.S. WEENING, S.R. KRIEG, J.D. BOS
Journal: British Journal of Dermatology (1990)

A questionnaire was sent to 16 carriers of the X-linked cytochrome-b558 negative variant of chronic granulomatous disease (CGD). Of the 15 who answered the questionnaire and from data of one additional case, 70% reported recurrent aphthous stomatitis and 63% had recurrent skin eruptions. Five of the carriers (31%) had clinically discoid lupus erythematosus (DLE), although the histopathology was not typical and the immunofluorescence findings were negative. The infiltrate in the lesional skin of three of these patients was analysed using monoclonal antibodies against CD3, CD4, CD8, CDIa, HLA-DR, CDIc, interdigitating cells, B lymphocytes and cells of the monocyte/macrophage lineage. The immunophenotype of the infiltrating cells resembled that found in discoid lupus erythematosus.
Ventriculoarterial coupling in normal and failing heart in humans.
Authors: HAsanoi, SSasayama, TKameyama
Journal: Circulation Research (1989)

To investigate coupling between the heart and arterial system in normal subjects and cardiac patients, we determined both the slope of the left ventricular end-systolic pressure-volume relation (ventricular elastance) and the slope of the arterial end-systolic pressure-stroke volume relation (effective arterial elastance) in three groups of subjects: group A, 12 subjects with ejection fraction of 60% or more; group B, seven patients with ejection fraction of 40-59%; and group C, nine patients with ejection fraction of less than 40%. We also determined the left ventricular stroke work, end-systolic potential energy, and the ventricular work efficiency defined as stroke work per pressure-volume area (stroke work + potential energy). In group A, ventricular elastance was nearly twice as large as arterial elastance. This is a condition for a maximal mechanical efficiency. In group B, ventricular elastance was almost equal to arterial elastance. This is a condition for maximal stroke work from a given end-dias...
Incomplete mitral leaflet closure in patients with papillary muscle dysfunction.
Authors: R WGodley, L SWann, E WRogers, HFeigenbaum, A EWeyman
Journal: Circulation (1981)

Clinical acceptance of an association between papillary muscle dysfunction and mitral regurgitation is widespread, despite the lack of objective support. To evaluate a possible association, we performed echocardiographic examinations on 22 patients with prior myocardial infarction and clinical evidence of papillary muscle dysfunction, 40 patients with prior myocardial infarction and no clinical evidence of papillary muscle dysfunction, and 20 normal subjects. There was a unique pattern of incomplete mitral leaflet closure in a high percentage (91%) of infarct patients with mitral regurgitation. In these patients, one or both leaflets were effectively arrested within the cavity of the left ventricle during ventricular systole. Dyskinetic wall motion in the region immediately surrounding one of the papillary muscles was present in 23 of 24 patients (96%) with demonstrated incomplete closure. This study provides the first objective evidence that de novo mitral regurgitation in patients with prior myocardial ...
Letter by Morel et al Regarding Article, “Ischemic Postconditioning During Primary Percutaneous Coronary Intervention: The Effects of Postconditioning on Myocardial Reperfusion in Patients With ST-Segment Elevation Myocardial Infarction (POST) Randomized Trial”
Authors: Olivier Morel, Malak Abbas, Valérie Schini-Kerth
Journal: Circulation (2014)
Costs of Care and Administration at For-Profit and Other Hospitals in the United States
Authors: Mary Cox
Journal: New England Journal of Medicine (1997)

Methods We calculated administrative costs for 6227 nonfederal hospitals and the total costs of inpatient care for 5201 acute care hospitals in the United States for fiscal year 1994 on the basis of data the hospitals submitted to Medicare. We analyzed similar data for fiscal year 1990. Using multivariate analysis, we assessed the effect of hospital ownership (private not-for-profit, for-profit, and public) on administrative costs, controlling for hospital type, census region, hospital size, and the proportion of revenues derived from outpatient services. We adjusted inpatient costs for local wage levels, hospitals’ reporting periods, and case mix.
Coronary arteriolar myogenic response is independent of endothelium.
Authors: LKuo, W MChilian, M JDavis
Journal: Circulation Research (1990)

The purpose of this study was to investigate if myogenic responses of isolated coronary arterioles were dependent on an intact, functional endothelium. Arterioles were located in situ by intracoronary perfusion with india ink-gelatin solution and then dissected and cannulated at both ends with glass micropipettes. Intraluminal pressure was initially set at 60 cm H2O; then the pressure was altered in steps of 20 cm H2O over a range of 20-140 cm H2O. Arterioles developed spontaneous tone and exhibited a significant myogenic response in physiological saline solution (36 degrees -37 degrees C). Arteriolar dilation and constriction were observed at lower (20-60 cm H2O) and higher (60-140 cm H2O) pressures, respectively. The presence of a functional and automatically intact endothelium was confirmed by relaxation to the endothelium-dependent vasodilator bradykinin and by transmission electron microscopy, respectively. After mechanical denudation of the endothelium with a specially designed abrasive micropipette...
<i>ACE</i> I/D Polymorphism, Plasma ACE Levels, and Long-term Kidney Outcomes or All-Cause Death in Patients With Type 1 Diabetes
Authors: Yawa Abouleka, Kamel Mohammedi, Charlyne Carpentier, Severine Dubois, Pierre Gourdy, Jean-François Gautier, Ronan Roussel, André Scheen, François Alhenc-Gelas, Samy Hadjadj, Gilberto Velho, Michel Marre
Journal: Diabetes Care (2021)

OBJECTIVE The deletion (D) allele of the ACE insertion/deletion (I/D) polymorphism is a risk factor for diabetic kidney disease. We assessed its contribution to long-term kidney outcomes and all-cause death in patients with long-standing type 1 diabetes. RESEARCH DESIGN AND METHODS A total of 1,155 participants from three French and Belgian cohorts were monitored for a median duration of 14 (interquartile range 13) years. The primary outcome was the occurrence of end-stage kidney disease (ESKD) or a 40% drop in the estimated glomerular filtration rate (eGFR). Secondary outcomes were the individual components of the primary outcome, rapid decline in eGFR (steeper than –3 mL/min/1.73 m2 per year), incident albuminuria, all-cause death, and a composite ESKD or all-cause death. Hazard ratios (HRs) for XD versus II genotype and for baseline plasma ACE levels were computed by Cox analysis. Genotype performance in stratifying the primary outcome was tested. RESULTS Genotype distribution was 954 XD and 201 II. The primary outcome occurred in 20% of XD and 13% of II carriers: adjusted HR 2.07 (95% CI 1.32–3.40; P = 0.001). Significant associations were also observed for rapid decline in eGFR, incident albuminuria, ESKD, all-cause death, and ESKD or all-cause death. Baseline plasma ACE levels were higher in XD carriers and significantly associated with an increased risk of the primary outcome. The ACE genotype enhanced net reclassification improvement (0.154, 95% CI 0.007–0.279; P = 0.04) and integrated discrimination improvement (0.012, 95%CI 0.001–0.021; P = 0.02) for primary outcome stratification. CONCLUSIONS The D-allele of the ACE I/D polymorphism was associated with an increased risk of major kidney events and all-cause death in patients with long-standing type 1 diabetes.
How Sharing Clinical Notes Affects the Patient-Physician Relationship
Authors: Rita Rubin
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evidence for a possible role of the brain kallikrein-kinin system in the modulation of the cerebral circulation.
Authors: TKamitani, M HLittle, E FEllis
Journal: Circulation Research (1985)

Experiments by others have shown that exogenous bradykinin dilates cerebral arterioles and that the brain contains kininogen and kallikrein, the latter being the enzyme which converts kininogen to bradykinin. The objective of these experiments was to determine if bradykinin produced from endogenous brain kininogen can affect the cerebral microcirculation. Rabbit pial arteriolar diameter was measured with a microscope using the closed cranial window technique. Topical application of bradykinin (10(-8)-10(-5) M) induced a dose-dependent vasodilation (8-46%) which was completely inhibited by the cyclooxygenase enzyme inhibitors indomethacin and meclofenamic acid. Topical application of 1 U of tissue kallikrein per milliliter of artificial cerebrospinal fluid induced 43% dilation, which could be prevented by local treatment with indomethacin or the proteinase inhibitor aprotinin. The action of aprotinin and indomethacin was specific, since aprotinin did not affect the dilation produced by bradykinin, and indo...
Experimental atrial septal defect closure with a new, transcatheter, self-centering device.
Authors: G SDas, GVoss, GJarvis, KWyche, RGunther, R FWilson
Journal: Circulation (1993)

BACKGROUNDDespite two decades of research, a transcatheter atrial septal defect closure device is not available for clinical use. We have designed a new superelastic Nitinol-Dacron, double-disk, self-centering, atrial septal defect closure device and studied its efficacy in a canine model of atrial septal defects.METHODS AND RESULTSAtrial septal defects were created surgically in 20 adult dogs using either a 7.5-mm or 10-mm punch. Percutaneous transcatheter closures were attempted using a new device. The device sizes used were 20 mm in 6 dogs, 22 mm in 9, and 25 mm in 5 (22.1 +/- 1.9 mm, mean +/- SD). The stretched atrial septal defect diameter was 10.5 +/- 1.3 mm, and the device to stretched atrial septal defect diameter ratio was 2.1 +/- 0.3. Closures were successful in 19 studies and unsuccessful in 1. Angiography showed a left-to-right shunt in all 20 dogs before closure. Immediately after closure (n = 19), there were no shunts in 17 and trivial shunts in 2. Six dogs were followed for a period of 4.7 ...
Widespread Subcutaneous Emphysema After an Endoscopic Submucosal Dissection (ESD): An Unusual Presentation of A Rare Complication
Authors: D Luna, I Iborra, M Puig, A Calm, L González, F Cañete, I Marin, N Caballero, J Colan-Hernández, V Moreno de Vega, H Uchima
Journal: Endoscopy (2021)

Perforation during rectal ESD is uncommon. Although, related complications could develop. Patient with a granular-mixed lateral spreading tumor(LST-G-M) of 50x50mm in the distal rectum. An ESD was performed.
Technical Outcomes of Ercp Procedures in Patients With Covid-19
Authors: T Voiosu, A Voiosu, I Boškoski, M Arvanitakis, M Bronswijk, M Hollenbach, A Benguș, P Bălănescu, B Orlandini, D Blero, S van der Merwe, RB Mateescu, J Devière, G Costamagna
Journal: Endoscopy (2021)

Aims The unprecedented situation caused by the COVID-19 pandemic has profoundly affected endoscopic practice in regard to access, volume, and workflow. We aimed to assess the potential changes in the technical outcomes of ERCP procedures carried out in patients with confirmed SARS-CoV-2 infection.
Preventive strategies in sexually transmitted diseases [letter]
Authors: Barringer Ta d
Journal: JAMA (1988)

The authors refute the recommendation that erythromycin or tetracycline are effective in the prevention of ophthalmia neonatorum by Chlamydia trachomatis.  In a prospective study of 118 infants born to mothers with chlamydial infection 11% of those who received silver nitrate 13% of those receiving erythromycin ointment and 16% of infants given tetracycline ointment developed chlamydial conjunctivitis.  All infected infants responded to oral erythromycin.  The ineffectiveness of neonatal prophylaxis with erythromycin ointment may be due to the fact that the replication time for Chlamydia is about 30 hours.  Perhaps repeated application would be more efficacious.
Ectopic Thoracic Kidney
Authors: John M. Palmer
Journal: JAMA (1971)

To the Editor.—  A recent case report inThe Journal( 215 :1158, 1971) describes an ectopic thoracic kidney discovered in an obese hypertensive woman with urinary tract infection. The abnormality presented as a thoracic mass. The authors noted unusually high position of the right kidney on intravenous pyelography and also mentioned a slight delay in excretion of dye on the right side as compared to the left. In addition, they noted incomplete filling of the inferior calyces on the right. No mention is made of angiography, isotope renography, or differential renal function studies to further evaluate the right kidney. They concluded that no surgical treatment was required for the ectopic kidney.  As first described by Maxwell and associates, 1 delayed excretion of contrast on the affected side is one of the most dependable radiographic signs of functionally significant main renal artery stenosis in patients with renovascular hypertension. In recent experience
Discordant Uptake Between Diagnostic 68Ga-HA-DOTATATE PET/CT and Posttherapy 177Lu-HA-DOTATATE SPECT/CT in Patients With Neuroendocrine Tumors
Authors: Daphne M.V. Huizing, Else A. Aalbersberg, Bernies van der Hiel, Marcel P.M. Stokkel, Michelle W.J. Versleijen
Journal: Clinical Nuclear Medicine (2021)

Patients with unresectable or metastasized neuroendocrine tumors are assumed eligible for PRRT (peptide receptor radionuclide therapy) with 177Lu-HA-DOTATATE if tumor uptake on somatostatin receptor imaging is higher than normal liver tissue. In our clinic, 2 patients presented with sufficient uptake of 68Ga-HA-DOTATATE in most metastases but with limited uptake in liver lesions. Posttherapy 177Lu imaging, however, showed good uptake in all neuroendocrine tumor lesions, including all liver metastases. Therefore, the presence of liver metastases in which the uptake of 68Ga-HA-DOTATATE is not or only slightly higher than in surrounding normal liver tissue should not be an absolute contraindication for PRRT.
Coordination of cardiac transplantation: patient processing and donor organ procurement.
Authors: F DDavis
Journal: Circulation (1987)

As cardiac transplantation has evolved into a viable therapeutic option for some terminally ill patients with end-stage heart disease, the role of clinical transplant and donor organ procurement coordinators has evolved into a new health profession. These well-trained, highly skilled, and dedicated individual's permeate all levels of the organ transplantation process, providing continuity of care and smoothness to a complicated path of operation.
11C-Choline PET/CT Depiction of Rectal Gastrointestinal Stromal Tumor
Authors: Ba D. Nguyen
Journal: Clinical Nuclear Medicine (2021)

Abstract 18 F-FDG PET/CT is an established imaging modality for gastrointestinal stromal tumor evaluation and its posttherapeutic monitoring. 68 Ga-PSMA has been recently reported with the incidental demonstration of this neoplasm on PET/CT. The author presents an uncommon case of this tumor detected by 11 C-choline during the assessment of prostate cancer.