tbuckley/cabot-search huggingface dataset:
Abstract P4-05-13: Prognostic implication of Yin Yang 1 (YY1) overexpression in patients with primary breast cancer
Authors: Chihwan Cha, Hosub Park, Chul Geun Kim, Min Sung Chung
Journal: Cancer Research (2022)

Abstract Background: YY1 is conserved transcriptional factor that highly expressed in various types of cancers. It regulates differential epigenetic pathways and protein modifications. However, there is still unknown whether YY1 overexpression has any prognostic significance in breast cancer patients. In this study, we evaluated YY1 expression levels using tissue microarrays and analyzed clinicopathologic characteristics with survival outcomes. Methods: Clinical information and tissue blocks were obtained retrospectively from 491 patients who underwent surgery at Hanyang University Hospital between 2002 and 2016. Immunohistochemical staining was performed using rabbit monoclonal antibody (ab-109237). YY1 expression was determined using H-score. Overexpression was defined as H-score ≥ 28.4 (mean value). Overall survival (OS) and disease-free survival (DFS) was analyzed by Kaplan Meier analysis. Results: Of 491 patients with primary breast cancer, 138 (28.1%) patients had YY1 overexpression. Luminal subtype (ER+/HER2-), early tumor stage, and low grade tumor were significantly associated with overexpression (P&amp;lt;0.0001). In patients with luminal subtype, overexpression was significantly correlated with early nodal stage and low proliferation index (Ki-67≤20%, P=0.014). After median follow up 67 months, YY1 overexpression was significantly associated with better prognosis (OS rates; 96.4% vs. 88.1%, P=0.038 and DFS rates; 92.0% vs. 79.2%, P=0.014). In luminal subtype, patients with overexpression showed better DFS (93.0% vs. 80.2%, P=0.043). In a Cox proportional hazards model, YY1 overexpression was independent significant prognostic factor after adjustment of ER/HER2 status and tumor size (hazard ratio; 0.5, 95% CI [0.26-0.98], P=0.042). Conclusion: YY1 overexpression is a better prognostic marker in patients with primary breast cancer, especially in luminal subtype. Citation Format: Chihwan Cha, Hosub Park, Chul Geun Kim, Min Sung Chung. Prognostic implication of Yin Yang 1 (YY1) overexpression in patients with primary breast cancer [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P4-05-13.
BPI22-011: Accreditation Systems Reduce Time to Treatment Delays; Three-Year Review of a South African Internationally Accredited Site
Authors: Carol-Ann Benn
Journal: Journal of the National Comprehensive Cancer Network (2022)

"BPI22-011: Accreditation Systems Reduce Time to Treatment Delays; Three-Year Review of a South African Internationally Accredited Site" published on 31 Mar 2022 by National Comprehensive Cancer Network.
Improving Perinatal Maternal Mental Health Starts With Addressing Structural Inequities
Authors: Lauren C. Shuffrey, Moriah E. Thomason, Natalie H. Brito
Journal: JAMA Psychiatry (2022)

Psychological distress during the perinatal period has increased during the COVID-19 pandemic.A systematic review of 81 studies (N = 132 917 pregnant or postpartum women; research published prior to January 31, 2021) reported prevalence of depression and anxiety ranging from 20% to 64% during the ongoing pandemic. 1Although there is still a need to examine more representative samples, a large cross-sectional study 1 of mostly US women corroborated these findings, reporting clinical levels of depression in 36% of perinatal women compared with an estimated prepandemic prevalence of 11% to 17%.Changes in prenatal care and childbirth experiences, including lack of support during delivery and recovery, may also contribute to heightened feelings of distress.Women who gave birth during the pandemic reported an increased acute stress response to childbirth (odds ratio, 1.38; 95% CI, 1.01-1.89),correlating with increased posttraumatic stress disorder symptoms and maternal bonding or breastfeeding problems.In this Viewpoint, we focus on the potential consequences of perinatal maternal mental health on child development and highlight structural inequities that need to be addressed to mitigate maternal psychological distress and improve both maternal and child health and well-being.
SARS-COV-2 VACCINE INDUCED MYOCARDITIS WITH SEVERE QT PROLONGATION
Authors: Jake Cordell Martinez, Damir Vukomanovic, Varun Tandon, Siamac Yazdchi, Hassan Beydoun, Michael Morris, Prakash Balan, Samuel Unzek, Farouk Mookadam
Journal: Journal of the American College of Cardiology (2022)
Abstract P1-19-01: Palbociclib plus endocrine therapy significantly enhances overall survival of HR+/HER2- metastatic breast cancer patients compared to endocrine therapy alone - A large institutional study
Authors: Akshara Singareeka Raghavendra, Min Jin Ha, Nicole M. Kettner, Senthil Damodaran, Rachel Layman, Kelly K Hunt, Yu Shen, Debu Tripathy, Khandan Keyomarsi
Journal: Cancer Research (2022)

Abstract PURPOSE: Cyclin-dependent kinase 4/6 inhibitor (CDKi) therapy combined with endocrinetherapy is considered standard of care for patients with advanced hormone receptor (HR)-positive, HER2-negative breast cancer (BC). The Breast Medical Oncology Database at MDAnderson Cancer Center (MDACC) was analyzed to assess effectiveness of CDKi+palbociclib. PATIENTS AND METHODS: From a total of 5402 advanced HR+ HER2- BC patients referred toMDACC between 1997 and 2020, we identified eligible patients who received palbociclib incombination with first- (n=778) and second-line (n=410) endocrine therapy. We furtheridentified “control” patients who received endocrine therapy alone in the first- (n=2452) andsecond-line (n=1183) setting. We conducted a propensity score matching analysis to balancethe baseline demographic and clinical characteristics between the palbociclib treated andcontrol cohorts to assess the effect of palbociclib treatment on progression-free survival (PFS)and overall survival (OS). Stratified log-rank test was used to assess the effect of palbociclib inthe matched cohorts. RESULTS: For the propensity-matched cohort in the first-line setting (n=708), the palbociclibgroup had significantly longer median PFS (17.4 vs. 11.1 months; p&amp;lt;0.0001) compared tocontrols. Median OS (44.3 vs. 40.2 months; p =1) did not show any survival benefit in the firstline setting. However, in the second-line setting, with 380 propensity-matched cohort, thepalbociclib group had significantly longer PFS (10 vs 5 months, p&amp;lt;0.0001) as well as OS (33 vs 24months; p &amp;lt; 0.022), compared to controls.2. CONCLUSION: In this single center analysis, of a large cohort of metastatic HR+ HER2- BCpatients, palbociclib in combination with endocrine therapy was associated with improved PFSin both first- and second-line settings and OS in the second-line setting compared withendocrine therapy alone cohort.3 Citation Format: Akshara Singareeka Raghavendra, Min Jin Ha, Nicole M. Kettner, Senthil Damodaran, Rachel Layman, Kelly K Hunt, Yu Shen, Debu Tripathy, Khandan Keyomarsi. Palbociclib plus endocrine therapy significantly enhances overall survival of HR+/HER2- metastatic breast cancer patients compared to endocrine therapy alone - A large institutional study [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P1-19-01.
CENTENARIAN TAVI: THE OLDEST KNOWN TRANS-CATHETER AORTIC VALVE IMPLANTATION
Authors: Safwan Gaznabi, Karan Gupta, Senthil Balasubramanian, Juan Pablo Salazar Adum, Iva Minga, Mark B. Lampert, Justin Paul Levisay
Journal: Journal of the American College of Cardiology (2022)
HIGHER CUMULATIVE SYSTOLIC BLOOD PRESSURE IS ASSOCIATED WITH POORER LEFT ATRIAL FUNCTION IN THE ABSENCE OF LEFT ATRIAL ENLARGEMENT: THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY
Authors: Jeremy Van't Hof, Romil Parikh, Riccardo Inciardi, Kunihiro Matsushita, Alvaro Alonso, Amil M. Shah, Scott D. Solomon, Lin Yee Chen
Journal: Journal of the American College of Cardiology (2022)
INDEX OF MICROCIRCULATORY RESISTANCE PREDICTS MICROVASCULAR OBSTRUCTION AND LEFT VENTRICULAR EJECTION FRACTION SIX MONTHS POST ST-ELEVATION MYOCARDIAL INFARCTION: A SYSTEMATIC REVIEW AND META-REGRESSION ANALYSIS
Authors: Prajith Jeyaprakash, Philopatir Mikhail, Faraz Pathan, Tom J. Ford, Colin Berry, Kazuaki Negishi
Journal: Journal of the American College of Cardiology (2022)
44P A first-in-human, open-label, dose-escalation study to investigate the safety and tolerability of CHC2014, a tropomyosin receptor kinase (TRK) inhibitor, in adult patients with advanced solid tumors
Authors: T. Yun, S.J. Shin, D-W. Kim, C.H. Yun, S. Heo, B. Hyun, Y.S. Kim, J.S. Kim, Y.W. Moon
Journal: Annals of Oncology (2022)
AN UNUSUAL CASE OF COMPLETE HEART BLOCK IN OSTIUM SECUNDUM ATRIAL SEPTAL DEFECT
Authors: Zurain Niaz, Kevin Schrader, Venkata Missula, Prashanth Singanallur, Robert Kropp, Mohamad Sukkari, Luke Schiller, Michael Gleason, Daniel Holtz, Manjari R. Regmi, Muhammad Adil Sheikh, Raj Patel, Abhishek Kalidas Kulkarni
Journal: Journal of the American College of Cardiology (2022)
MALIGNANCIES AND PULMONARY EMBOLISM: IN-HOSPITAL MORTALITY RATES STRATIFIED BASED ON TYPE OF CANCER FROM NATIONAL INPATIENT SAMPLE
Authors: Dae Yong Park, Seokyung An, Mukunthan Murthi, Bharosa Sharma, Sujitha Velagapudi, Aviral Vij
Journal: Journal of the American College of Cardiology (2022)
RELATIONSHIP BETWEEN ADMISSION TROPONIN AND OUTCOMES IN CRITICALLY ILL PATIENTS WITH HEART DISEASE AND COVID-19 IN A TERTIARY CENTER IN BRAZIL
Authors: Eduardo Moreira, Henrique Pinesi, Melina Valdo, Pedro Henrique Marins, Andre Luiz Nascimento, Arthur Assis, Eduardo Gomes Lima, Fabio Grunspun Pitta, Ludhmila Hajjar, Juliana Ferreira, Carlos V. Serrano, Cibele Larrosa Garzillo
Journal: Journal of the American College of Cardiology (2022)
Abstract ES8-4: Axillary management in upfront surgery - staging, local control or both?
Authors: S Wong
Journal: Cancer Research (2022)

Abstract Axillary management in women undergoing upfront surgery for operable breast cancer has changed dramatically over the last several decades. Axillary lymph node dissection (ALND), a procedure that was historically used in both clinically node negative and node positive patients to stage the axilla and optimize locoregional control, is associated with the potential for significant long-term morbidity in the form of upper extremity lymphedema, paresthesia, and shoulder dysfunction. Efforts to minimize the morbidity associated with ALND, as well as the recognition that only a minority of patients with clinically node negative disease are found to have nodal metastases at the time of axillary surgery, prompted the development and validation of sentinel lymph node biopsy (SLNB). In women who are clinically node negative, SLNB has been shown to accurately stage the axilla without compromising oncologic outcomes, identifying nodal disease in up to 30% of cases. The application of clinical trial data from Z0011 and AMAROS in T1-T2 breast cancer with 1-2 positive lymph nodes undergoing breast conservation allow for omission of completion ALND with no impact on locoregional control or survival. The ongoing POSNOC trial (NCT02401685) will further determine whether women with T1-T2 disease undergoing breast conservation or mastectomy require directed axillary treatment in the form of ALND or axillary radiation to minimize the risk of axillary failure. An altogether omission of axillary staging in clinically node negative breast cancer remains an area of evolving interest, with CALGB 9343 trial data supporting this approach in older women with stage I estrogen-receptor positive (ER+) HER2- breast cancer. Trials examining the omission of SLNB in other select patient populations with negative axillary imaging are the subject of ongoing investigation. At present, prognostic information derived from SLNB for clinically node negative women undergoing upfront surgery for early-stage triple negative and HER2+ breast cancer, premenopausal ER+HER2- breast cancer, and BRCA1/2-associated breast cancer remain important for adjuvant systemic therapy decision-making. Citation Format: S Wong. Axillary management in upfront surgery - staging, local control or both? [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr ES8-4.
The development of live biotherapeutics against <i>Clostridioides difficile</i> infection towards reconstituting gut microbiota
Authors: Yongrong Zhang, Ashley Saint Fleur, Hanping Feng
Journal: Gut Microbes (2022)

Clostridioides difficile is the most prevalent pathogen of nosocomial diarrhea. In the United States, over 450,000 cases of C. difficile infection (CDI), responsible for more than 29,000 deaths, are reported annually in recent years. Because of the emergence of hypervirulent strains and strains less susceptible to vancomycin and fidaxomicin, new therapeutics other than antibiotics are urgently needed. The gut microbiome serves as one of the first-line defenses against C. difficile colonization. The use of antibiotics causes gut microbiota dysbiosis and shifts the status from colonization resistance to infection. Hence, novel CDI biotherapeutics capable of reconstituting normal gut microbiota have become a focus of drug development in this field.
OUTCOME OF DIFFERENT ABLATION STRATEGIES IN PERSISTENT AND LONG-STANDING PERSISTENT ATRIAL FIBRILLATION: RESULTS FROM A MULTICENTER RANDOMIZED TRIAL (TANTRA)
Authors: Sanghamitra Mohanty, Prasant Mohanty, Chintan Trivedi, Michela Casella, Antonio Dello Russo, Paolo Compagnucci, Domenico Giovanni Della Rocca, Carola Gianni, Paolo China, Sakis Themistoclakis, Bryan MacDonald, Angel Mayedo, Amin Al-Ahmad, Rodney P. Horton, Mohamed Bassiouny, Gerald Gallinghouse, John Burkhardt, Luigi Di Biase, Claudio Tondo, Andrea Natale
Journal: Journal of the American College of Cardiology (2022)
Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state
Authors: Xiao-Qing Dai, Joan Camunas-Soler, Linford J.B. Briant, Theodore dos Santos, Aliya F. Spigelman, Emily M. Walker, Rafael Arrojo e Drigo, Austin Bautista, Robert C. Jones, Dana Avrahami, James Lyon, Aifang Nie, Nancy Smith, Yongneng Zhang, Janyne Johnson, Jocelyn E. Manning Fox, Evangelos D. Michelakis, Peter E. Light, Klaus H. Kaestner, Seung K. Kim, Patrik Rorsman, Roland W. Stein, Stephen R. Quake, Patrick E. MacDonald
Journal: Cell Metabolism (2022)

In diabetes, glucagon secretion from pancreatic α cells is dysregulated. The underlying mechanisms, and whether dysfunction occurs uniformly among cells, remain unclear. We examined α cells from human donors and mice using electrophysiological, transcriptomic, and computational approaches. Rising glucose suppresses α cell exocytosis by reducing P/Q-type Ca2+ channel activity, and this is disrupted in type 2 diabetes (T2D). Upon high-fat feeding of mice, α cells shift toward a "β cell-like" electrophysiological profile in concert with indications of impaired identity. In human α cells we identified links between cell membrane properties and cell surface signaling receptors, mitochondrial respiratory chain complex assembly, and cell maturation. Cell-type classification using machine learning of electrophysiology data demonstrated a heterogenous loss of "electrophysiologic identity" in α cells from donors with type 2 diabetes. Indeed, a subset of α cells with impaired exocytosis is defined by an enrichment in progenitor and lineage markers and upregulation of an immature transcriptomic phenotype, suggesting important links between α cell maturation state and dysfunction.
Unique molecular characteristics of NAFLD-associated liver cancer accentuate β-catenin/TNFRSF19-mediated immune evasion
Authors: Alissa Michelle Wong, Xiaofan Ding, Aikha Melissa Wong, Mingjing Xu, Luyao Zhang, Howard Ho-Wai Leung, Anthony Wing-Hung Chan, Qi Xiu Song, Joseph Kwong, Loucia Kit-Ying Chan, Matthew Man, Mian He, Jinna Chen, Zhe Zhang, Wenxing You, Coleen Lau, Allen Yu, Yingying Wei, Yunfei Yuan, Paul Bo-San Lai, Jingmin Zhao, Kwan Man, Jun Yu, Michael Kahn, Nathalie Wong
Journal: Journal of Hepatology (2022)

The hepatic manifestation of the metabolic syndrome, non-alcoholic fatty liver disease (NAFLD), can lead to the development of hepatocellular carcinoma (HCC). Despite a strong causative link, NAFLD-HCC is often underrepresented in systematic genome explorations.Herein, tumor-normal pairs from 100 patients diagnosed with NAFLD-HCC were subject to next-generation sequencing. Bioinformatic analyses were performed to identify key genomic, epigenomic and transcriptomic events associated with the pathogenesis of NAFLD-HCC. Establishment of primary patient-derived NAFLD-HCC culture was used as a representative human model for downstream in vitro investigations of the underlying CTNNB1 S45P driver mutation. A syngeneic immunocompetent mouse model was used to further test the involvement of CTNNB1mutand TNFRSF19 in reshaping the tumor microenvironment.Mutational processes operative in the livers of patients with NAFLD inferred susceptibility to tumor formation through defective DNA repair pathways. Dense promoter mutations and dysregulated transcription factors accentuated activated transcriptional regulation in NAFLD-HCC, in particular the enrichment of MAZ-MYC activities. Somatic events common in HCCs arising from NAFLD and viral hepatitis B infection underscore similar driver pathways, although an incidence shift highlights CTNNB1mut dominance in NAFLD-HCC (33%). Immune exclusion correlated evidently with CTNNB1mut. Chromatin immunoprecipitation-sequencing integrated with transcriptome and immune profiling revealed a unique transcriptional axis, wherein CTNNB1mut leads to an upregulation of TNFRSF19 which subsequently represses senescence-associated secretory phenotype-like cytokines (including IL6 and CXCL8). This phenomenon could be reverted by the Wnt-modulator ICG001.The unique mutational processes in the livers of patients with NAFLD and NAFLD-HCC allude to a "field effect" involving a gain-of-function role of CTNNB1 mutations in immune exclusion.The increasing prevalence of metabolic syndrome in adult populations means that NAFLD is poised to be the major cause of liver cancer in the 21st century. We showed a strong "field effect" in the livers of patients with NAFLD, wherein activated β-catenin was involved in reshaping the tumor-immune microenvironment.
Reversal of Imaging Findings of Idiopathic Intracranial Hypertension After Lumbar Puncture
Authors: Anish Kapadia, Erin Wong, Chris Heyn
Journal: JAMA Neurology (2022)

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TRICUSPID REGURGITATION DISEASE PROGRESSION AND MACHINE LEARNING-BASED CLUSTER ANALYSIS OF GREATER THANMODERATE TRICUSPID REGURGITATION REVEALS DISTINCT POPULATION WITH DIFFERENT PHENOTYPES AND CLINICALOUTCOMES
Authors: Shaefali Padiyar, Shizhen Liu, Miguel Sotelo, Chris Rogers, Loren Wagner, Pradeep K. Yadav, Vivek Rajagopal, Amy E. Simone, Vibhav S. Rangarajan, Peter Flueckiger, Vinod H. Thourani, Mani A. Vannan
Journal: Journal of the American College of Cardiology (2022)
m<sup>6</sup>A‐mediated regulation of PBX1‐GCH1 axis promotes gastric cancer proliferation and metastasis by elevating tetrahydrobiopterin levels
Authors: Yinan Liu, Ertao Zhai, Junting Chen, Yan Qian, Risheng Zhao, Yan Ma, Jianqiu Liu, Zhixin Huang, Shirong Cai, Jianhui Chen
Journal: Cancer Communications (2022)

Methyltransferase 3 (METTL3)-mediated N6-methyladenosine (m6 A) RNA modification has been demonstrated to be a potential factor in promoting gastric cancer (GC). METTL3 regulates a series of signaling pathways by modifying various mRNAs. This study aimed to identify novel METTL3-mediated signaling pathways and explored possible targets for use in the clinical setting of gastric cancer.To investigate the proliferation and metastatic capacity of GC cell lines with METTL3 knockdown, a xenograft, lung metastasis, and popliteal lymph node metastasis model was used. The m6 A-modified RNA immunoprecipitation (Me-RIP) sequence was utilized to explore the target mRNAs of METTL3. Cell counting kit 8 and transwell assays were performed to investigate the promoting function of pre-B cell leukemia homeobox 1 (PBX1) and GTP cyclohydrolase 1 (GCH1). Western blotting and chromatin immunoprecipitation were employed to confirm the involvement of the METTL3-PBX1-GCH1 axis. ELISA and liquid chromatography-mass spectrometry were used to explore the biological function of tetrahydrobiopterin (BH4 ).Knockdown of METTL3 suppressed xenograft tumor growth and lung/lymph node metastasis in vivo. Mechanistically, we found that METTL3 combined with and stabilized PBX1 mRNAs. Chromatin immunoprecipitation (ChIP) and further experiments suggested that PBX1 acted as a transcription factor inducing GCH1 expression. Moreover, the METTL3-PBX1-GCH1 axis increased BH4 levels in GC cells, thereby promoting tumor progression.This study suggested that METTL3 enzymes promote tumor growth and lung/lymph node metastasis via METTL3-PBX1-GCH1 axis increasing BH4 levels in GC.
OMEGA-3 FATTY ACID USE IS ASSOCIATED WITH LOWER MORTALITY BUT NOT WITH CARDIOVASCULAR EVENTS REDUCTION IN PATIENTS WITH DIABETES: RESULTS OF 4786 PATIENTS FROM KOREAN NATIONAL HEALTH INSURANCE SERVICE COHORT
Authors: Sang-Ho Jo, Sung-Ai Kim, Hong-Mi Choi, Hyun-Sook Kim
Journal: Journal of the American College of Cardiology (2022)
Production of human spinal-cord organoids recapitulating neural-tube morphogenesis
Authors: Ju-Hyun Lee, Hyogeun Shin, Mohammed R. Shaker, Hyun Jung Kim, Si-Hyung Park, June Hoan Kim, Namwon Lee, Minjin Kang, Subin Cho, Tae Hwan Kwak, Jong Woon Kim, Mi-Ryoung Song, Seung-Hae Kwon, Dong Wook Han, Sanghyuk Lee, Se-Young Choi, Im Joo Rhyu, Hyun Kim, Dongho Geum, Il-Joo Cho, Woong Sun
Journal: Nature Biomedical Engineering (2022)