tbuckley/cabot-search huggingface dataset:
Partitioned glioma heritability shows subtype-specific enrichment in immune cells
Authors: Quinn T Ostrom, Jacob Edelson, Jinyoung Byun, Younghun Han, Ben Kinnersley, Beatrice Melin, Richard S Houlston, Michelle Monje, Christopher I Amos, Jill S Barnholtz-Sloan, Jonine L Bernstein, Melissa L Bondy, Elizabeth B Claus, Richard S Houlston, Dora Il’yasova, Robert B Jenkins, Christoffer Johansen, Daniel Lachance, Rose Lai, Beatrice S Melin, Ryan T Merrell, Sara H Olson, Siegal Sadetzki, Joellen Schildkraut, Sanjay Shete, Kyle M Walsh, Christopher I Amos, Melissa L Bondy
Journal: Neuro-Oncology (2021)

Epidemiological studies of adult glioma have identified genetic syndromes and 25 heritable risk loci that modify individual risk for glioma, as well increased risk in association with exposure to ionizing radiation and decreased risk in association with allergies. In this analysis, we assess whether there is a shared genome-wide genetic architecture between glioma and atopic/autoimmune diseases.Using summary statistics from a glioma genome-wide association studies (GWAS) meta-analysis, we identified significant enrichment for risk variants associated with gene expression changes in immune cell populations. We also estimated genetic correlations between glioma and autoimmune, atopic, and hematologic traits using linkage disequilibrium score regression (LDSC), which leverages genome-wide single-nucleotide polymorphism (SNP) associations and patterns of linkage disequilibrium.Nominally significant negative correlations were observed for glioblastoma (GB) and primary biliary cirrhosis (rg = -0.26, P = .0228), and for non-GB gliomas and celiac disease (rg = -0.32, P = .0109). Our analyses implicate dendritic cells (GB pHM = 0.0306 and non-GB pHM = 0.0186) in mediating both GB and non-GB genetic predisposition, with GB-specific associations identified in natural killer (NK) cells (pHM = 0.0201) and stem cells (pHM = 0.0265).This analysis identifies putative new associations between glioma and autoimmune conditions with genomic architecture that is inversely correlated with that of glioma and that T cells, NK cells, and myeloid cells are involved in mediating glioma predisposition. This provides further evidence that increased activation of the acquired immune system may modify individual susceptibility to glioma.
P76.41 Detection of Diverse EGFR c-terminal Truncations (C-trunc) and Sensitivity to Tyrosine Kinase Inhibitors (TKIs) in the Clinic
Authors: C. Lovly, J. Lee, R. Madison, O. Humblet, C. Cho-Phan, Z. Du, B. Alexander, J. Venstrom, A. Schrock
Journal: Journal of Thoracic Oncology (2021)
Point-of-Care Digital Cytology With Artificial Intelligence for Cervical Cancer Screening in a Resource-Limited Setting
Authors: Oscar Holmström, Nina Linder, Harrison Kaingu, Ngali Mbuuko, Jumaa Mbete, Felix Kinyua, Sara Törnquist, Martin Muinde, Leena Krogerus, Mikael Lundin, Vinod Diwan, Johan Lundin
Journal: JAMA Network Open (2021)

<h3>Importance</h3> Cervical cancer is highly preventable but remains a common and deadly cancer in areas without screening programs. The creation of a diagnostic system to digitize Papanicolaou test samples and analyze them using a cloud-based deep learning system (DLS) may provide needed cervical cancer screening to resource-limited areas. <h3>Objective</h3> To determine whether artificial intelligence–supported digital microscopy diagnostics can be implemented in a resource-limited setting and used for analysis of Papanicolaou tests. <h3>Design, Setting, and Participants</h3> In this diagnostic study, cervical smears from 740 HIV-positive women aged between 18 and 64 years were collected between September 1, 2018, and September 30, 2019. The smears were digitized with a portable slide scanner, uploaded to a cloud server using mobile networks, and used to train and validate a DLS for the detection of atypical cervical cells. This single-center study was conducted at a local health care center in rural Kenya. <h3>Exposures</h3> Detection of squamous cell atypia in the digital samples by analysis with the DLS. <h3>Main Outcomes and Measures</h3> The accuracy of the DLS in the detection of low- and high-grade squamous intraepithelial lesions in Papanicolaou test whole-slide images. <h3>Results</h3> Papanicolaou test results from 740 HIV-positive women (mean [SD] age, 41.8 [10.3] years) were collected. The DLS was trained using 350 whole-slide images and validated on 361 whole-slide images (average size, 100 387 × 47 560 pixels). For detection of cervical cellular atypia, sensitivities were 95.7% (95% CI, 85.5%-99.5%) and 100% (95% CI, 82.4%-100%), and specificities were 84.7% (95% CI, 80.2%-88.5%) and 78.4% (95% CI, 73.6%-82.4%), compared with the pathologist assessment of digital and physical slides, respectively. Areas under the receiver operating characteristic curve were 0.94 and 0.96, respectively. Negative predictive values were high (99%-100%), and accuracy was high, particularly for the detection of high-grade lesions. Interrater agreement was substantial compared with the pathologist assessment of digital slides (κ = 0.72) and fair compared with the assessment of glass slides (κ = 0.36). No samples that were classified as high grade by manual sample analysis had false-negative assessments by the DLS. <h3>Conclusions and Relevance</h3> In this study, digital microscopy with artificial intelligence was implemented at a rural clinic and used to detect atypical cervical smears with a high sensitivity compared with visual sample analysis.
P76.77 Combination of EGFR-TKIs with Chemotherapy versus EGFR-TKIs alone in EGFR-Mutant Advanced NSCLC with Concomitant Genetic Alterations
Authors: W. Feng, W. Gu, H. Zhang, Y. Lu, W. Gu, M. Li, S. Yang, J. Zhang, Z. Ye, Q. Lin, Y. Liang, H. Chen, Y. Cheng, M. Yao
Journal: Journal of Thoracic Oncology (2021)
Unmet Need for Equipment to Help With Bathing and Toileting Among Older US Adults
Authors: Kenneth Lam, Ying Shi, John Boscardin, Kenneth E. Covinsky
Journal: JAMA Internal Medicine (2021)

Home modification through seemingly mundane equipment, such as grab bars and shower seats, mitigates injury, dependence, and reduced quality of life in older adults coping with increasing disability. However, whether these interventions are underused in the US is unclear.To estimate how many older adults who need equipment to help with bathing and toileting do not have it, describe factors associated with not having equipment, and describe how many who did not initially have equipment acquired equipment over time.This observational cohort study of participants 65 years or older used secondary data from the 2015 to 2019 waves of the US National Health and Aging Trends Study. Participants included community-dwelling older adults who would unequivocally benefit from equipment, defined as those with poor physical performance or substantial difficulty bathing, toileting, transferring, or walking. Respondents were representative of the US population 65 years and older. Data were collected from May 2015 to October 2019 and analyzed from August 1, 2019, to February 24, 2021.Population characteristics (eg, age, sex, income, health conditions, and physical performance), environmental factors (eg, home ownership and living arrangement), and health behaviors (eg, prior knee and/or hip surgery).Prevalence of any unmet need for equipment, defined as either needing bathing equipment (bath grab bars and shower seat) but having none or needing toileting equipment (toilet grab bars and raised toilet seat) but having none and the cumulative incidence of equipment acquisition during 4 years of follow-up.A total of 2614 participants representing 12 million US individuals would benefit from equipment. The mean (SD) age was 80.5 (8.2) years, and 1619 individuals (62%) were women. Of these, an estimated 5 million individuals (42%; 95% CI, 39%-44%) had an unmet need. After adjustment for age, sex, and race/ethnicity, unmet need was associated with younger age (49% if aged 65-74 years, 37% if aged 75-84 years, and 29% if aged ≥85 years; P < .001), having fewer health conditions (55% if none vs 39% if ≥3; P = .002), non-White race/ethnicity (40% if White vs 51% if Black, 54% if Hispanic, and 55% if other; P < .001), no recent hospitalization (46% vs 37% if hospitalized; P = .001), and no prior knee and/or hip fracture or surgery (46% vs 35% if prior fracture or surgery; P < .001). After 4 years of follow-up, 35% of those with bathing equipment needs and 52% of those with toileting equipment needs never received equipment.This cohort study suggests that in the US, 42% of older adults with impairments that would make bathing or toileting difficult lack equipment to assist. This situation is a missed opportunity to help 5 million individuals live independently and safely.
Abstract 10528: All-In-One: Echocardiography and Biomarkers for Tako-Tsubo Syndrome Diagnosis
Authors: Simone Persampieri, Federica Valli, Ludovico Sabatelli, Giulia Ferrante, Laura Massironi, Marco Centola, Diego Castini, Stefano Carugo
Journal: Circulation (2018)

Introduction: Tako-tsubo syndrome (TS) mimics myocardial infarction (MI) in clinical presentation, ECG modifications and biomarkers elevation. Echocardiography can suggest a clinical suspicion of T...
P09.43 Familial History of Cancer and Overall Survival in NSCLC Patients
Authors: D. Maciel Santana, L.B. Mendes Gomes, M.D. Spina Donadio, M.F. Barbosa De Medeiros, C.I. De Andrade Souza, M.F. Simões, H. De Freitas, M. Petrocchi Corassa, V.C. De Lima
Journal: Journal of Thoracic Oncology (2021)
Increased Adipose Tissue Fibrogenesis, Not Impaired Expandability, Is Associated With Nonalcoholic Fatty Liver Disease
Authors: Joseph W. Beals, Gordon I. Smith, Mahalakshmi Shankaran, Anja Fuchs, George G. Schweitzer, Jun Yoshino, Tyler Field, Marcy Matthews, Edna Nyangau, Darya Morozov, Bettina Mittendorfer, Marc K. Hellerstein, Samuel Klein
Journal: Hepatology (2021)

It is proposed that impaired expansion of subcutaneous adipose tissue (SAT) and an increase in adipose tissue (AT) fibrosis causes ectopic lipid accumulation, insulin resistance (IR), and metabolically unhealthy obesity. We therefore evaluated whether a decrease in SAT expandability, assessed by measuring SAT lipogenesis (triglyceride [TG] production), and an increase in SAT fibrogenesis (collagen production) are associated with NAFLD and IR in persons with obesity.In vivo abdominal SAT lipogenesis and fibrogenesis, expression of SAT genes involved in extracellular matrix (ECM) formation, and insulin sensitivity were assessed in three groups of participants stratified by adiposity and intrahepatic TG (IHTG) content: (1) healthy lean with normal IHTG content (Lean-NL; n = 12); (2) obese with normal IHTG content and normal glucose tolerance (Ob-NL; n = 25); and (3) obese with NAFLD and abnormal glucose metabolism (Ob-NAFLD; n = 25). Abdominal SAT TG synthesis rates were greater (P < 0.05) in both the Ob-NL (65.9 ± 4.6 g/wk) and Ob-NAFLD groups (71.1 ± 6.7 g/wk) than the Lean-NL group (16.2 ± 2.8 g/wk) without a difference between the Ob-NL and Ob-NAFLD groups. Abdominal SAT collagen synthesis rate and the composite expression of genes encoding collagens progressively increased from the Lean-NL to the Ob-NL to the Ob-NAFLD groups and were greater in the Ob-NAFLD than the Ob-NL group (P < 0.05). Composite expression of collagen genes was inversely correlated with both hepatic and whole-body insulin sensitivity (P < 0.001).AT expandability is not impaired in persons with obesity and NAFLD. However, SAT fibrogenesis is greater in persons with obesity and NAFLD than in those with obesity and normal IHTG content, and is inversely correlated with both hepatic and whole-body insulin sensitivity.
P76.72 A PET and MRI Study Exploring Osimertinib Brain Exposure and Efficacy in EGFRm NSCLC CNS Metastases
Authors: S. Ekman, Z. Cselényi, A. Varrone, A. Jucaite, H. Martin, M. Schou, P. Johnström, G. Laus, R. Lewensohn, A. Brown, J. Van Der Aart, K. Vishwanathan, L. Farde
Journal: Journal of Thoracic Oncology (2021)
Pharmacological insights into autophagy modulation in autoimmune diseases
Authors: Ming-Yue Wu, Er-Jin Wang, Du Feng, Min Li, Richard D. Ye, Jia-Hong Lu
Journal: Acta Pharmaceutica Sinica B (2021)

As a cellular bulk degradation and survival mechanism, autophagy is implicated in diverse biological processes. Genome-wide association studies have revealed the link between autophagy gene polymorphisms and susceptibility of autoimmune diseases including systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD), indicating that autophagy dysregulation may be involved in the development of autoimmune diseases. A series of autophagy modulators have displayed protective effects on autoimmune disease models, highlighting the emerging role of autophagy modulators in treating autoimmune diseases. This review explores the roles of autophagy in the autoimmune diseases, with emphasis on four major autoimmune diseases [SLE, rheumatoid arthritis (RA), IBD, and experimental autoimmune encephalomyelitis (EAE)]. More importantly, the therapeutic potentials of small molecular autophagy modulators (including autophagy inducers and inhibitors) on autoimmune diseases are comprehensively analyzed.
Combination of <scp>CD19</scp> and <scp>CD22 CAR‐T</scp> cell therapy in relapsed B‐cell acute lymphoblastic leukemia after allogeneic transplantation
Authors: Shuangyou Liu, Biping Deng, Zhichao Yin, Yuehui Lin, Lihong An, Dan Liu, Jing Pan, Xinjian Yu, Bingzhen Chen, Tong Wu, Alex H. Chang, Chunrong Tong
Journal: American Journal of Hematology (2021)

Abstract The prognosis of relapsed acute lymphoblastic leukemia (ALL) after allogeneic transplantation is dismal when treated with conventional approaches. While single‐target CD19 or CD22 chimeric antigen receptor (CAR) T‐cell therapy has achieved high complete remission (CR) rates in refractory/relapsed B‐ALL, it could not maintain a durable remission in most patients. To prolong relapse‐free survival, we sequentially combined CD19 and CD22 CAR‐T cells to treat post‐transplant relapsed B‐ALL patients with both CD19/CD22 antigen expression on lymphoblasts. Patient‐derived donor cells were collected to produce CAR‐T cells that were transfected by lentiviral vectors encoding second generation CARs composed of CD3ζ and 4–1BB. The second T‐cell infusion was scheduled at least 1 month, and usually within 6 months after the first CAR‐T treatment. Twenty‐seven adult and pediatric patients, including 11 (41%) with extramedullary diseases (EMD), received the first CD19 CAR‐T and 23 (85%) achieved CR. Subsequently, 21 out of 27 patients received the second CD22 CAR‐T and were followed‐up for a median of 19.7 (range, 5.6–27.3) months; 14 cases remained in CR, seven relapsed and two of them died from disease progression; Kaplan–Meier survival analysis showed overall survival and event‐free survival rates of 88.5% and 67.5%, respectively, at both 12 months and 18 months. CAR‐T associated graft‐versus‐host disease (GVHD) occurred in 23% of patients, with 8% new‐onset acute GVHD and 15% persistent or worsened pre‐existing cGVHD before CAR‐T. This combination strategy of sequential CD19 and CD22 CAR‐T therapy significantly improved the long‐term survival in B‐ALL patients who relapsed after transplantation.
Profiling chromatin accessibility in pediatric acute lymphoblastic leukemia identifies subtype-specific chromatin landscapes and gene regulatory networks
Authors: Jonathan D. Diedrich, Qian Dong, Daniel C. Ferguson, Brennan P. Bergeron, Robert J. Autry, Maoxiang Qian, Wenjian Yang, Colton Smith, James B. Papizan, Jon P. Connelly, Kohei Hagiwara, Kristine R. Crews, Shondra M. Pruett-Miller, Ching-Hon Pui, Jun J. Yang, Mary V. Relling, William E. Evans, Daniel Savic
Journal: Leukemia (2021)
Beclometasone dipropionate/formoterol maintenance and reliever therapy asthma exacerbation benefit increases with blood eosinophil level
Authors: Guy Brusselle, Gabriele Nicolini, Luigi Santoro, Daniele Guastalla, Alberto Papi
Journal: European Respiratory Journal (2021)

<b>BDP/FF MART regimen reduced the incidence of severe asthma exacerbations compared with BDP/FF maintenance therapy plus salbutamol as needed across the blood eosinophil continuum, with a trend to a greater reduction in patients with higher baseline counts</b>https://bit.ly/3AGSMaX
HSR21-075: CancerSupportSource®-Caregiver: Psychometric Properties of 2-Item Depression and Anxiety Risk Screening Measures for Informal Cancer Caregivers
Authors: Alexandra K. Zaleta, Melissa F. Miller, Erica E. Fortune, Kelly A. Clark, Elissa C. Kranzler
Journal: Journal of the National Comprehensive Cancer Network (2021)

"HSR21-075: CancerSupportSource®-Caregiver: Psychometric Properties of 2-Item Depression and Anxiety Risk Screening Measures for Informal Cancer Caregivers" published on 17 Mar 2021 by National Comprehensive Cancer Network.
Neurohormonal modulation in pulmonary arterial hypertension
Authors: Eva L. Peters, Harm Jan Bogaard, Anton Vonk Noordegraaf, Frances S. de Man
Journal: European Respiratory Journal (2021)

Pulmonary hypertension is a fatal condition of elevated pulmonary pressures, complicated by right heart failure. Pulmonary hypertension appears in various forms; one of those is pulmonary arterial hypertension (PAH) and is particularly characterised by progressive remodelling and obstruction of the smaller pulmonary vessels. Neurohormonal imbalance in PAH patients is associated with worse prognosis and survival. In this back-to-basics article on neurohormonal modulation in PAH, we provide an overview of the pharmacological and nonpharmacological strategies that have been tested pre-clinically and clinically. The benefit of neurohormonal modulation strategies in PAH patients has been limited by lack of insight into how the neurohormonal system is changed throughout the disease and difficulties in translation from animal models to human trials. We propose that longitudinal and individual assessments of neurohormonal status are required to improve the timing and specificity of neurohormonal modulation strategies. Ongoing developments in imaging techniques such as positron emission tomography may become helpful to determine neurohormonal status in PAH patients in different disease stages and optimise individual treatment responses.
Evaluating the World Health Organization Model List of Essential Medicines for skin disease
Authors: C.W. Rundle, A.P. Fortugno, J. Maghfour, C.L. Presley, K. Pulsipher, S.S. Husayn, L. Naldi, O. Chosidow, R. Hay, R.P. Dellavalle
Journal: British Journal of Dermatology (2021)
Comparison of Fruit and Vegetable Intake Among Urban Low-Income US Adults Receiving a Produce Voucher in 2 Cities
Authors: Sanjay Basu, Melissa Akers, Seth A. Berkowitz, Kevin Josey, Dean Schillinger, Hilary Seligman
Journal: JAMA Network Open (2021)

<h3>Importance</h3> Fruit and vegetable vouchers have been implemented by cities and counties across the US to increase fruit and vegetable intake and thereby improve overall nutritional quality. <h3>Objective</h3> To determine whether and why use of fruit and vegetable vouchers are associated with varied nutritional intake across different populations and environments. <h3>Design, Setting, and Participants</h3> In a population-based pre-post cohort study of 671 adult participants with low income before and during (6 months after initiation) participation in a 6-month program, fruit and vegetable vouchers were distributed for redemption at local San Francisco and Los Angeles neighborhood grocery and corner stores between 2017 and 2019. A transportability analysis was performed to identify factors that may explain variation in voucher use between cities. <h3>Exposure</h3> Receipt of $20 per month in produce vouchers for 6 months from 2017 to 2019. <h3>Main Outcomes and Measures</h3> Change in total fruits and vegetables (as defined by the US Department of Agriculture) consumed per person per day (change in cup-equivalents between month 6 and month 0). <h3>Results</h3> A total of 671 adults (median age, 54.9 years [interquartile range, 45.0-65.0 years]; 61.7% female; 30.9% Black; 19.7% Hispanic) were enrolled. An increase in fruit and vegetable intake of 0.22 cup-equivalents per day overall (95% CI, 0.14-0.31 cup-equivalents;<i>P</i> &lt; .001) was observed. However, the observed increase was larger in Los Angeles compared with San Francisco (0.64 cup-equivalents per day; 95% CI, 0.41-0.88 cup-equivalents vs 0.10 cup-equivalents per day; 95% CI, 0.01-0.19 cup-equivalents). When the concurrently sampled San Francisco group (n = 157) was weighted in transportability analysis to demographically match the Los Angeles group (n = 155) in observed covariates, the weighted San Francisco group had an estimated increase of 0.53 fruit and vegetable cup-equivalents per day (95% CI, 0.27- 0.79 cup-equivalents,<i>P</i> = .03), with income being the variable needed to allow the 95% confidence intervals to overlap between the weighted San Francisco and unweighted Los Angeles populations. <h3>Conclusions and Relevance</h3> In this study, the use of fruit and vegetable vouchers appeared to be associated with greater benefit among those with lower incomes, suggesting that further investigation of flat-rate rather than income-scaled benefits is warranted.
大腿膝窩動脈におけるニチノールステント留置後の6年間転帰:大腿膝窩動脈病変のステント留置の後向き多施設解析(REAL FP)
Authors: Iida Osamu, Soga Yoshimitsu, Hirano Keisuke, Suzuki Kenji, Uematsu Masaaki, Yokoi Hiroyoshi, Nobuyoshi Masakiyo, Muramatsu Toshiya, Inoue Naoto, Nanto Shinsuke, Nagata Seiki
Journal: Circulation (2011)
P42.02 Evaluating the Feasibility of a Deep Learning-Based Computer-Aided Detection System for Lung Nodule Detection in a Lung Cancer Screening Program
Authors: X. Cui, S. Zheng, M. Heuvelmans, Y. Du, G. Sidorenkov, M. Dorrius, R. Veldhuis, M. Oudkerk, G. De Bock, P. Van Ooijen, R. Vliegenthart, Z. Ye
Journal: Journal of Thoracic Oncology (2021)
FP03.03 Clinical Activity of BMS-986012, an Anti–Fucosyl-GM1 Monoclonal Antibody, Plus Nivolumab in Small Cell Lung Cancer
Authors: Q. Chu, N. Leighl, V. Surmont, C. Van Herpen, A. Sibille, B. Markman, S. Clarke, R. Juergens, M. Acosta Rivera, V. Andelkovic, C. Rudin, S. Snow, D. Kim, M. Sanatani, S. Tannenbaum-Dvir, P. Basciano, D. Lathers, K. Urbanska, G. Kollia, C. He, A. Dipiero, N. Ready
Journal: Journal of Thoracic Oncology (2021)
P87.01 Higher Dose Alectinib for Advanced RET+ NSCLC: Results from the RET+ Cohort of the Blood First Assay Screening Trial (BFAST)
Authors: N. Peled, S. Ponce, J. Alatorre-Alexander, A. Kinkolykh, B. Vicuna, M. Mathisen, S. Mocci, S. Paul, E. Schleifman, R. Dziadziuszko
Journal: Journal of Thoracic Oncology (2021)
P41.09 Comorbidity Profile and Diagnostic Complication Risk: A Study of the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial
Authors: E. Robinson, J. Wisnivesky, C.Y. Kong, G. Mhango, W. Raad, R. Flores, M. Kale
Journal: Journal of Thoracic Oncology (2021)
Human rights and fair access to COVID-19 vaccines: the International AIDS Society–Lancet Commission on Health and Human Rights
Authors: Chris Beyrer, Pascale Allotey, Joseph J Amon, Stefan D Baral, Mary T Bassett, Harriet Deacon, Lorraine T Dean, Lilianne Fan, Rita Giacaman, Carolyn Gomes, Sofia Gruskin, Samer Jabbour, Michel Kazatchkine, Lucy Stackpool-Moore, Allan Maleche, Martin McKee, Sandra Hsu Hnin Mon, Vera Paiva, Alena Peryskina, Dainius Pūras, Leonard Rubenstein, Adeeba Kamarulzaman, Lawrence Corey
Journal: The Lancet (2021)
Seroprevalence of SARS-CoV-2 Antibodies in the US Adult Asymptomatic Population as of September 30, 2020
Authors: Robert L. Stout, Steven J. Rigatti
Journal: JAMA Network Open (2021)

Estimated US Infection- and Vaccine-Induced SARS-CoV-2 Seroprevalence Based on Blood Donations, July 2020-May 2021
FP12.13 Therapeutic Index Predicts Clinical Outcome of both Treated and Treatment-Naïve NSCLC Patients Receiving Targeted- and Immune-Therapy
Authors: X. Niu, Z. Zhou, Z. Chen, Y. Yu, L. Shen, Z. Li, K. Liu, J. Bai, A. Yang, L. Wu, S. Lu
Journal: Journal of Thoracic Oncology (2021)