tbuckley/cabot-search huggingface dataset:
Land Cover of Early-Life Environment Modulates the Risk of Type 1 Diabetes
Authors: Noora Nurminen, Damiano Cerrone, Jussi Lehtonen, Anirudra Parajuli, Marja Roslund, Maria Lönnrot, Jorma Ilonen, Jorma Toppari, Riitta Veijola, Mikael Knip, Juho Rajaniemi, Olli H. Laitinen, Aki Sinkkonen, Heikki Hyöty
Journal: Diabetes Care (2021)

OBJECTIVE Environmental microbial exposures have been implicated to protect against immune-mediated diseases such as type 1 diabetes. Our objective was to study the association of land cover around the early-life dwelling with the development of islet autoimmunity and type 1 diabetes to evaluate the role of environmental microbial biodiversity in the pathogenesis. RESEARCH DESIGN AND METHODS Association between land cover types and the future risk of type 1 diabetes was studied by analyzing land cover types classified according to Coordination of Information on the Environment (CORINE) 2012 and 2000 data around the dwelling during the first year of life for 10,681 children genotyped for disease-associated HLA-DQ alleles and monitored from birth in the Type 1 Diabetes Prediction and Prevention (DIPP) study. Land cover was compared between children who developed type 1 diabetes (n = 271) or multiple diabetes-associated islet autoantibodies (n = 384) and children without diabetes who are negative for diabetes autoantibodies. RESULTS Agricultural land cover around the home was inversely associated with diabetes risk (odds ratio 0.37, 95% CI 0.16–0.87, P = 0.02 within a distance of 1,500 m). The association was observed among children with the high-risk HLA genotype and among those living in the southernmost study region. Snow cover on the ground seemed to block the transfer of the microbial community indoors, leading to reduced bacterial richness and diversity indoors, which might explain the regional difference in the association. In survival models, an agricultural environment was associated with a decreased risk of multiple islet autoantibodies (hazard ratio [HR] 1.60, P = 0.008) and a decreased risk of progression from single to multiple autoantibody positivity (HR 2.07, P = 0.001) compared with an urban environment known to have lower environmental microbial diversity. CONCLUSIONS The study suggests that exposure to an agricultural environment (comprising nonirrigated arable land, fruit trees and berry plantations, pastures, natural pastures, land principally occupied by agriculture with significant areas of natural vegetation, and agroforestry areas) early in life is inversely associated with the risk of type 1 diabetes. This association may be mediated by early exposure to environmental microbial diversity.
ARTIFICIAL INTELLIGENCE EVALUATION OF CORONARY STENOSIS ON CT CORONARY ANGIOGRAPHY, COMPARISON WITH QUANTITATIVE CORONARY ANGIOGRAPHY; A CREDENCE TRIAL SUB-STUDY
Authors: James P. Earls, Andrew Choi, William F. Griffin, Hugo Marques, Emil Barkovich, Joanna Riess
Journal: Journal of the American College of Cardiology (2021)
Appropriate Use of Point-of-Care Ultrasonography in Patients With Acute Dyspnea in Emergency Department or Inpatient Settings: A Clinical Guideline From the American College of Physicians
Authors: Amir Qaseem, Itziar Etxeandia-Ikobaltzeta, Reem A. Mustafa, Devan Kansagara, Nick Fitterman, Timothy J. Wilt
Journal: Annals of Internal Medicine (2021)

The American College of Physicians (ACP) developed this guideline to provide clinical recommendations on the appropriate use of point-of-care ultrasonography (POCUS) in patients with acute dyspnea in emergency department (ED) or inpatient settings to improve the diagnostic, treatment, and health outcomes of those with suspected congestive heart failure, pneumonia, pulmonary embolism, pleural effusion, or pneumothorax.The ACP Clinical Guidelines Committee based this guideline on a systematic review on the benefits, harms, and diagnostic test accuracy of POCUS; patient values and preferences; and costs of POCUS. The systematic review evaluated health outcomes, diagnostic timeliness, treatment decisions, and test accuracy. The critical health, diagnostic, and treatment outcomes evaluated were in-hospital mortality, time to diagnosis, and time to treatment. The important outcomes evaluated were intensive care unit admissions, correctness of diagnosis, disease-specific outcomes, hospital readmissions, length of hospital stay, and quality of life. The critical test accuracy outcomes included false-positive results for suspected pneumonia, pneumothorax, and pulmonary embolism and false-negative results for suspected congestive heart failure, pneumonia, pneumothorax, and pulmonary embolism. Important test accuracy outcomes included false-positive results for suspected congestive heart failure and false-negative and false-positive results for suspected pleural effusion. This guideline was developed using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) method.The target audience is all clinicians, and the target patient population is adult patients with acute dyspnea in ED or inpatient settings.ACP suggests that clinicians may use point-of-care ultrasonography in addition to the standard diagnostic pathway when there is diagnostic uncertainty in patients with acute dyspnea in emergency department or inpatient settings (conditional recommendation; low-certainty evidence).
RATE OF INCREASE IN REPRESENTATION OF WOMEN IN CARDIOLOGY PROCEDURAL AND SURGICAL TRAINING PROGRAMS
Authors: Sharmin Hossain, Shayne Dodge, Kinan Bachour, Stephen Kearing, Michelle Capdeville, Melissa Levack, Tom Nguyen, Ranya Sweis, Sonya Burgess, Sarah Zaman, Megan Coylewright
Journal: Journal of the American College of Cardiology (2021)
LONG-TERM SAFETY OF MAVACAMTEN IN PATIENTS WITH OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY: INTERIM RESULTS OF THE MAVA-LONG TERM EXTENSION (LTE) STUDY
Authors: Florian Rader, Lubna Choudhury, Sara Saberi, David Fermin, Matthew T. Wheeler, Theodore P. Abraham, Artur Oreziak, Pablo Garcia-Pavia, Donna Zwas, Amy J. Sehnert, Ganesh Balaratnam, Grace Ma, Iacopo Olivotto
Journal: Journal of the American College of Cardiology (2021)
LONG-TERM CARDIOVASCULAR OUTCOMES AFTER ORLISTAT THERAPY IN PATIENTS WITH OBESITY: A NATIONWIDE, PROPENSITY SCORE MATCHED COHORT STUDY
Authors: Maddalena Ardissino, Matthew Vincent, Oliver Hines, Christian Eichhorn, Ravi Amin, Osama Moussa, Peter Collins, Sanjay Purkayastha
Journal: Journal of the American College of Cardiology (2021)
LEFT ATRIAL STRUCTURAL REMODELING IMPACTS THE FUNCTION OF THE LEFT ATRIUM IN ATRIAL FIBRILLATION PATIENTS: A MAGNETIC RESONANCE IMAGING STUDY
Authors: Lilas Dagher, Yichi Zhang, Aneesh Dhore, Michael Crawford, Alan Morris, Eugene Kholmovski, Tarek Ayoub, Raman Danrad, Chao Huang, Nassir Marrouche
Journal: Journal of the American College of Cardiology (2021)
ROLE OF GUIDELINE DIRECTED MEDICAL THERAPY OPTIMIZATION IN PATIENTS HOSPITALIZED WITH DECOMPENSATED SYSTOLIC HEART FAILURE
Authors: Dennis Grewal, Payush Chatta, Gary Fraser, Antoine Sakr, Liset Stoletniy, Rod Partow-Navid, Joshua Coney, Dmitry Abramov
Journal: Journal of the American College of Cardiology (2021)
SLEEP APNEA AND RECURRENT HEART FAILURE HOSPITALIZATIONS AFTER CORONARY ARTERY BYPASS GRAFTING
Authors: Yao Hao Teo, Wilson W. Tam, Chieh Yang Koo, Aye-Thandar Aung, Ching Hui Sia, Raymond Wong, William Kong, Theodoros Kofidis, Pipin Kojodjojo, Chi-Hang Lee
Journal: Journal of the American College of Cardiology (2021)
PROCEDURAL EFFICIENCY AND TIMING OF THE RETROGRADE APPROACH IN ENDOVASCULAR TREATMENT FOR CHRONIC TOTAL OCCLUSION OF THE SUPERFICIAL FEMORAL ARTERY
Authors: Yutaka Tadano, Jun-ichi Kotani, Takuya Haraguchi, Tomohiko Watanabe, Takuro Sugie, Daitaro Kanno, Yoshifumi Kashima, Tsutomu Fujita
Journal: Journal of the American College of Cardiology (2021)
ANGIOPOIETIN-2 IS A POWERFUL PREDICTOR OF SEVERITY OF ILLNESS, RIGHT VENTRICULAR DYSFUNCTION AND IN HOSPITAL MORTALITY IN ACUTE PULMONARY EMBOLISM
Authors: Joshua Newman, Yevgeniy Brailovsky, Sorcha Allen, Dalila Masic, Emily Bontekoe, Jeanine Walenga, Jawed Fareed, Amir Darki
Journal: Journal of the American College of Cardiology (2021)
COMPARATIVE EFFECTIVENESS OF VASOPRESSORS AND INOTROPES IN CARDIOGENIC SHOCK
Authors: Arjun Aggarwal, Manoj Thangam, Richard Bach, John Lasala, Sunil Rao, C. Michael Gibson, David Kandzari, Jason Katz, Elena Deych, Pratik Doshi, Prakash Balan, Karen Joynt Maddox, Amit Amin
Journal: Journal of the American College of Cardiology (2021)
EFFECT OF ICOSAPENT ETHYL ON PERCENT ATHEROMA VOLUME IN PATIENTS WITH ELEVATED TRIGLYCERIDES ON STATIN THERAPY - INSIGHTS FROM THE EVAPORATE TRIAL
Authors: Suvasini Lakshmanan, Chandana Shekar, April Kinninger, Ilana Golub, Sajad Hamal, Divya Birudaraju, Lavanya Cherukuri, Khadije Ahmad, Matthew Chen, George Trad, John Robert Luce, Sion Roy, John Nelson, Deepak Bhatt, Matthew Budoff
Journal: Journal of the American College of Cardiology (2021)
Out-of-Network Laboratory Test Spending, Utilization, and Prices in the US
Authors: Zirui Song, Timothy Lillehaugen, Jacob Wallace
Journal: JAMA (2021)

In the context of concerns about the appropriateness and costs to insurers and patients of laboratory testing, this study uses data from the IBM MarketScan Commercial Claims and Encounters Database to examine out-of-network laboratory test spending, utilization, and prices in the US in 2008-2016.
IMPLICATION OF OPTIMAL HEART RATE IN PATIENTS WITH SYSTOLIC DYSFUNCTION FOLLOWING TAVR
Authors: Teruhiko Imamura, Shuhei Tanaka, Ryuichi Ushijima, Mitsuo Sobajima, Nobuyuki Fukuda, Hiroshi Ueno, Koichiro Kinugawa
Journal: Journal of the American College of Cardiology (2021)
Peripheral artery disease in Germany (2009–2018): Prevalence, frequency of specialized ambulatory care and use of guideline-recommended therapy – A population-based study
Authors: Christos Rammos, Martin Steinmetz, Julia Lortz, Amir A. Mahabadi, Olga Petrikhovich, Kristina Kirsch, Ramona Hering, Mandy Schulz, Tienush Rassaf
Journal: The Lancet Regional Health - Europe (2021)

Peripheral artery disease (PAD) patients have high morbidity and mortality rates, demonstrating a need for improved treatment strategies. While underuse and undertreatment have been reported, there is no clear picture of patterns in population-level disease prevalence, prescription of guideline-recommended pharmacotherapy, or frequency of contact with dedicated specialists. We present population-level data on changes in prevalence, care and treatment of PAD from 2009 to 2018 in Germany.We analyzed the ambulatory claims data for all statutorily insured patients comprising 70.1 million patients each year and 87% of the German population. Prevalence was assessed by documentation of PAD and stratified by age and sex within the 10-year study timeframe. In addition, current ambulatory care, stratified by vascular specialists (vascular surgeons or angiologists), internists, cardiologists and primary care physicians, were examined.Prevalence increased from 1·85% in 2009 to 3·14% in 2018, affecting 2·3 million patients in 2018 and more males (55%) than females (45%). A low level of visits to vascular specialists, with 11·1% receiving care from vascular surgeons and 8·1% from angiologists, was shown. Moreover, analysis of guideline-recommended prescriptions revealed increasing, but still insufficient, prescription frequencies among PAD patients between 2009 and 2016, from 42·6% to 56% for statins and from 40·2% to 48·0% for antiplatelets.Our results show that the prevalence of PAD in Germany, as assessed by outpatient PAD documentation, is increasing and PAD patients are underutilizing specialized vascular care; moreover, the prescription frequency of guideline-recommended therapies remains low. There is a clear need to improve the referral and treatment algorithms in the high-risk PAD population.None.
COMPARING RISK FACTORS AND EARLY POSTOPERATIVE OUTCOMES IN ADULTS WITH EBSTEIN ANOMALY FOLLOWING CONE RECONSTRUCTION VERSUS TRICUSPID VALVE REPLACEMENT
Authors: Derek Opp, Joseph Dearani, Elizabeth Stephens, Devon Aganga, Amy Weaver, William Miranda, Frank Cetta, Jonathan Johnson, Charlotte Van Dorn
Journal: Journal of the American College of Cardiology (2021)
A rare condition masquerading as lung cancer
Authors: Eman Nasr, Sarah MacRae, Mike Dobson, David Russell, Mohamad Bittar
Journal: Thorax (2021)

A 63-year-old woman was referred to the lung cancer clinic after presenting to the emergency department with a 10-day history of fever, chest tightness and breathlessness. Chest X-ray showed a left-sided retrocardiac mass, and an urgent CT scan was requested.

On review, she reported a 2-month history of intermittent cough and night sweats. She denied weight loss or haemoptysis. She was an ex-smoker. Her medical history included two episodes of pneumonia in the 1980s. There was no history of recurrent childhood infections or exposure to tuberculosis. Performance status was zero and she worked for the NHS as an operating department practitioner.

CT scan demonstrated a left lower lobe mass suspicious for malignancy. Preliminary radiological staging was T4N0M0 (figure 1).



Figure 1 
Axial CT image showing left lower lobe mass.



On positron emission …
Clinical diagnosis of Alzheimer's disease: recommendations of the International Working Group
Authors: Bruno Dubois, Nicolas Villain, Giovanni B Frisoni, Gil D Rabinovici, Marwan Sabbagh, Stefano Cappa, Alexandre Bejanin, Stéphanie Bombois, Stéphane Epelbaum, Marc Teichmann, Marie-Odile Habert, Agneta Nordberg, Kaj Blennow, Douglas Galasko, Yaakov Stern, Christopher C Rowe, Stephen Salloway, Lon S Schneider, Jeffrey L Cummings, Howard H Feldman
Journal: The Lancet Neurology (2021)
Self-organization of power at will
Authors: Elpida Tzafestas
Journal: Behavioral and Brain Sciences (2021)

Abstract We challenge and extend Ainslie's top-down view of willpower as a dual function, resolve and suppression. Instead, we propose an alternative self-organizational view of the motivational system as a network of urges, incentives, drives, and so on that interact dynamically. With such a view, resolve, suppression, and other functions emerge under certain environmental and social conditions for certain personality profiles.
STATIN USE MAY BE ASSOCIATED WITH DECREASED SEVERITY OF COVID-19
Authors: Husam Shadid, Michael Pan, Elizabeth Anderson, Tariq Azam, Hanna Berlin, Chelsea Meloche, Rafey Feroze, Patrick O’Hayer, Abbas Bitar, Kishan Padalia, Erinleigh Michaud, Christopher Launius, Penelope Blakely, Salim Hayek
Journal: Journal of the American College of Cardiology (2021)
Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss
Authors: Siobhan Quenby, Ioannis D Gallos, Rima K Dhillon-Smith, Marcelina Podesek, Mary D Stephenson, Joanne Fisher, Jan J Brosens, Jane Brewin, Rosanna Ramhorst, Emma S Lucas, Rajiv C McCoy, Robert Anderson, Shahd Daher, Lesley Regan, Maya Al-Memar, Tom Bourne, David A MacIntyre, Raj Rai, Ole B Christiansen, Mayumi Sugiura-Ogasawara, Joshua Odendaal, Adam J Devall, Phillip R Bennett, Stavros Petrou, Arri Coomarasamy
Journal: The Lancet (2021)
MORTALITY IMPROVEMENT AFTER INSTITUTION OF A MULTIDISCIPLINARY HIGH-RISK CARDIOLOGY SERVICE
Authors: Jared Christensen, Karim Al-Azizi, LuAnn Caras, Chadi Dib, Alfred Levy, Trent Pettijohn, Sameh Sayfo, Molly Szerlip, Sibi Thomas, William Ryan, Srinivasa Potluri
Journal: Journal of the American College of Cardiology (2021)
Helen Salisbury: Let’s talk about sustainability
Authors: Helen Salisbury
Journal: BMJ (2021)

The pandemic has hastened the development and use of technology in general practice, and many advances have had the effect of shrinking our ecological footprint. Now that nearly all of our prescriptions are issued electronically—sent with just a few keystrokes to any pharmacy in England—whole forests’ worth of paper have been saved. I can send text messages straight from patients’ notes, including invitations to book appointments, notifications of results, and links to online resources. Patients can also reply by text, including photos if needed, and the whole correspondence is directly filed into the medical record.

Saving natural resources has created time efficiencies, reducing …
THREE-YEAR OUTCOME OF ALL-COMER PATIENTS TREATED WITH RESOLUTE ONYX ZOTAROLIMUS-ELUTING VERSUS ORSIRO SIROLIMUS-ELUTING STENTS IN THE RANDOMIZED BIONYX TRIAL
Authors: Eline Ploumen, Paolo Zocca, Rosaly A. Buiten, C. Doggen, Adel Aminian, Carl Schotborgh, Gillian A.J. Jessurun, Ariel Roguin, Peter W. Danse, Edouard Benit, Clemens von Birgelen, Thoraxcentrum Twente
Journal: Journal of the American College of Cardiology (2021)
CORONARY PERFUSION PRESSURE IS ASSOCIATED WITH ADVERSE CLINICAL OUTCOMES IN THE HF-ACTION STUDY
Authors: Kajal Shah, Kenneth Bilchick, Christiana Jeukeng, Hunter Mwansa, Persey Bediako, Patrick Stafford, Prerna Sharma, Khadijah Breathett, Scott Lim, Younghoon Kwon, Nishtha Sodhi, Nishaki Mehta, Sula Mazimba
Journal: Journal of the American College of Cardiology (2021)
FIFTEEN-YEAR CLINICAL OUTCOMES AFTER SIROLIMUS-ELUTING STENT IMPLANTATION
Authors: Chihiro Fujii, Chisato Ota, Kazunori Mushiake, Kenta Yoshida, Shunsuke Matsushita, Ryo Bando, Katsuya Miura, Masanobu Ohya, Shunsuke Kubo, Takeshi Tada, Hiroyuki Tanaka, Yasushi Fuku, Kazushige Kadota
Journal: Journal of the American College of Cardiology (2021)
In CKD, the effect of dapagliflozin on kidney outcomes did not vary by T2DM status or CKD cause
Authors: Orly F. Kohn
Journal: Annals of Internal Medicine (2021)

Source Citation Wheeler DC, Stefánsson BV, Jongs N, et al. Effects of dapagliflozin on major adverse kidney and cardiovascular events in patients with diabetic and non-diabetic chronic kidney disease: a prespecified analysis from the DAPA-CKD trial. Lancet Diabetes Endocrinol. 2021;9:22-31. 33338413
Abstract 9668: Greater Than the Sum of Its Parts: The Risk of Future Cardiovascular Disease (CVD) in Patients With Type 2 Diabetes (T2D), Prior Cardiovascular Disease or Both
Authors: Vincent J Willey, Chi Nguyen, Effie Kuti, Rakesh Luthra
Journal: Circulation (2019)

Introduction: There is a lack of consistency from published literature regarding the risk of future CVD in patients with T2D only vs. those with a prior history of CVD (and no T2D). The objective o...
SEX-SPECIFIC DIFFERENCES IN IN-HOSPITAL MANAGEMENT AND OUTCOMES OF PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND CARDIOGENIC SHOCK: AN ANALYSIS FROM THE NCDR CHEST PAIN REGISTRY
Authors: Islam Elgendy, Zachary Wegermann, Shuang Li, Maria Grau-Sepulveda, Nathaniel Smilowitz, Tracy Wang, Hani Jneid
Journal: Journal of the American College of Cardiology (2021)
Abstract 13115: Circulating MicroRNA-454-3p is Associated With Acute Kidney Injury in Patients With Acute Decompensated Heart Failure
Authors: Evelyn M Templeton, Moritz Lasse, Anna P Pilbrow, Vicky A Cameron, John W Pickering, Daniel Hertzberg, Chris M Frampton, Zoltan H Endre, Arthur M Richards, Robert N Doughty, Richard W Troughton
Journal: Circulation (2019)

Introduction: A quarter of patients with acute decompensated heart failure (ADHF) experience acute kidney injury (AKI), which doubles the risk of mortality at one year. MicroRNAs (miRNAs) have been...
Text-Book of Anatomy and Physiology for Nurses.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TIME TO FIRST SHOCK OR NO SHOCK: LONG-TERM FOLLOW-UP OF HYPERTROPHIC CARDIOMYOPATHY PATIENTS TREATED WITH AN IMPLANTABLE DEFIBRILLATOR
Authors: Christopher B. Gitter, Jay Sengupta, Susan Casey, Christian Schmidt, Opema Lohese, Ananya A. Shah, Kevin Harris, Robert Hauser
Journal: Journal of the American College of Cardiology (2021)
ASSESSMENT OF RIGHT VENTRICULAR SYSTOLIC FUNCTION USING ADVANCED 2D AND 3D ECHOCARDIOGRAPHIC IMAGING TO IDENTIFY CHANGES IN PATIENTS WITH PULMONARY HYPERTENSION OF INCREMENTAL STAGES
Authors: Qiong Zhao, Bryan Monroe, Carlotta Perego, Annunziata Cotugno, Nicole Shiao, Manijeh Vakilzadeh, Oksana Shlobin
Journal: Journal of the American College of Cardiology (2021)
PREGNANCY ASSOCIATED AORTIC COMPLICATIONS REQUIRING SURGERY: A REVIEW OF CONTEMPORARY EXPERIENCE IN 150 CASES BETWEEN 2000 TO 2020
Authors: Sawan Jalnapurkar, Hezzy Shmueli, Sorel Goland, Ramdas Pai, Vishal Arora, Uri Elkayam
Journal: Journal of the American College of Cardiology (2021)
Abstract 17020: Nationwide Analysis to Determine Mechanical Circulatory Support Device Use in Mechanical Complications of Acute Myocardial Infarction
Authors: ayesha shaik, Karthik Gonuguntla, Nikola Perosevic
Journal: Circulation (2020)

Introduction: Without timely reperfusion therapy, acute myocardial infarction (AMI) can lead to mechanical complications (MC) such as papillary muscle rupture (PMR), ventricular septal rupture (VSR), free wall rupture (FWR). Mechanical circulatory support (MCS) devices such as intra-aortic balloon pump (IABP), Impella and extracorporeal membrane oxygenation (ECMO) are used in cardiogenic shock associated with AMI-MC. Hypothesis: As per the SHOCK-II trial use of MCS in MI complicated cardiogenic shock showed no difference in mortality. We sought to determine the rates of AMI-MC, MCS device placements and outcomes associated with them. Methods: The Nationwide Inpatient Sample was queried from 2010 to 2014 using ICD-9 codes with a primary diagnosis of AMI. We also used diagnosis and procedure codes for MC and MCS devices. We excluded patients with NSTEMI. Results: From 2010 to 2014, we identified 3158 hospitalizations related to AMI-MC with a mean age of 64±13.4 years. Majority were men 69% with 75% Caucasian with an in-hospital mortality rate of 37%. Use of MCS was most common in males (67%), Caucasians (77%), and with an age group of 50-70 years (54%). Of these patients, PMR was noted in 13%, VSR in 31% and FWR in 56%. Rates of MCS devices were 38% (IABP 35%, Impella 3% and ECMO 4%). Overall use of MCS for FWR, VSR, PMR were 15%, 61%, 80%. Percentage of MC requiring IABP, Impella, ECMO were as follows; FWR (15%, 0.6%, 0.3%), VSR (58%, 7%, 6%), PMR (70%, 5%, 12%). Patients that received cardiac transplant was 0.2%. In-hospital mortality among patients who received MCS to those who did not receive MCS were 59% vs 24%; p&lt;0.001, among patients who received IABP to those who did not receive any MCS were 54% vs 24%; p&lt;0.001 and among patients who received Impella to no MCS were 86% vs 24%; p&lt;0.001. Conclusions: Based on the results, FWR was the most common MC. MCS were most commonly used in PMR followed by VSR, with IABP being the most common type. Patients on MCS had increased in-hospital mortality compared to those without MCS. Large randomized trials are needed to determine the effectiveness of these devices in predicting outcomes associated with AMI-MC
IMPACT OF VITAMIN D ON ATRIAL FIBRILLATION IN 25 HYDROXYVITAMIN D DEFICIENT ELDERLY PATIENTS: A STUDY FROM NATIONAL VA DATABASE
Authors: Tarun Dalia, Prakash Acharya, Sagar Ranka, Maya Safarova, Deepak Parashara, Rajat Barua
Journal: Journal of the American College of Cardiology (2021)