tbuckley/cabot-search huggingface dataset:
Cross-Sectional Estimation of Endogenous Biomarker Associations with Prenatal Phenols, Phthalates, Metals, and Polycyclic Aromatic Hydrocarbons in Single-Pollutant and Mixtures Analysis Approaches
Authors: Max T. Aung, Youfei Yu, Kelly K. Ferguson, David E. Cantonwine, Lixia Zeng, Thomas F. McElrath, Subramaniam Pennathur, Bhramar Mukherjee, John D. Meeker
Journal: Environmental Health Perspectives (2021)

BACKGROUND: Humans are exposed to mixtures of toxicants that can impact several biological pathways.We investigated the associations between multiple classes of toxicants and an extensive panel of biomarkers indicative of lipid metabolism, inflammation, oxidative stress, and angiogenesis.METHODS: We conducted a cross-sectional study of 173 participants (median 26 wk gestation) from the LIFECODES birth cohort.We measured exposure analytes of multiple toxicant classes [metals, phthalates, phenols, and polycyclic aromatic hydrocarbons (PAHs)] in urine samples.We also measured endogenous biomarkers (eicosanoids, cytokines, angiogenic markers, and oxidative stress markers) in either plasma or urine.We estimated pair-wise associations between exposure analytes and endogenous biomarkers using multiple linear regression after adjusting for covariates.We used adaptive elastic net regression, hierarchical Bayesian kernel machine regression, and sparse-group LASSO regression to evaluate toxicant mixtures associated with individual endogenous biomarkers.RESULTS: After false-discovery adjustment (q < 0:2), single-pollutant models yielded 19 endogenous biomarker signals associated with phthalates, 13 with phenols, 17 with PAHs, and 18 with trace metals.Notably, adaptive elastic net revealed that phthalate metabolites were selected for several positive signals with the cyclooxygenase (n = 7), cytochrome p450 (n = 7), and lipoxygenase (n = 8) pathways.Conversely, the toxicant classes that exhibited the greatest number of negative signals overall in adaptive elastic net were phenols (n = 20) and metals (n = 21).DISCUSSION: This study characterizes cross-sectional endogenous biomarker signatures associated with individual and mixtures of prenatal toxicant exposures.These results can help inform the prioritization of specific pairs or clusters of endogenous biomarkers and exposure analytes for investigating health outcomes.
Abstract 14635: The Fib-4 Index is a Risk Factor for Incident Cardiovascular Disease in Urban Male Residents: The Suita Study
Authors: Yoshihiro Kokubo, Masahiro Koseki, Makoto Watanabe, Aya Higashiyama, Yoko Nakao, Kyoko Honda-Kohmo, Yoshihiro Miyamoto
Journal: Circulation (2020)

Introduction: The fibrosis index based on four factors (FIB-4 index) is a score that predicts liver fibrosis easily, quickly, and inexpensively, but there is little evidence of its relationship with the onset of cardiovascular disease in general population in Japan. Therefore, we examined the relationship between incident cardiovascular disease (CVD) by the FIB-4 index level in urban area residents. Methods: We studied 5,333 follow-up Japanese individuals (2,478 men, 2,855 women) with no history of CVD in the Suita Study. The platelet count was measured at the time of medical examination. The FIB-4 index was calculated using age (yrs), alanine aminotransferase (ALT, IU/L), aspartate aminotransferase (AST, IU/L), and platelet count (PLT, 10^9/L) as follow: FIB-4 index = (AST x Age) / (PLT x (square root of ALT)). The primary endpoint was CVD events, including stroke or ischemic heart disease. The risk of CVD was analyzed by the FIB-4 index level using the Cox proportional hazards model adjusted by the components of the ischemic heart disease risk score in the Suita Study. Results: The percentage of the FIB-4 index ≥2.67 in the 30s to 80s at the baseline survey was 0%, 1%, 2%, 7,%, 21%, 43% for men, and 0%, 0%, 1%, 5%, 16%, 39% for women, respectively. During the mean follow-up period of 9.3 years, 195 strokes and 137 ischemic heart diseases were observed. Based on men with FIB-4 index &lt;1.30, the adjusted hazard ratio (95% confidence interval) for incident CVD in men with FIB-4 index ≥2.67 was 1.91 (1.05-3.47), those for incident ischemic heart disease in men with FIB-4 index 1.30-2.66 and ≥2.67 were 2.49 (1.33-4.64) and 3.29 (1.32-8.16), respectively. Conclusion: The FIB-4 index was considered to be useful as a predictor of ischemic heart disease in urban men in Japan.
Value of Discharging Heart Failure Patients Home
Authors: Peter Y. Watson
Journal: JAMA Cardiology (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Association of Machine Learning–Based Predictions of Medial Knee Contact Force With Cartilage Loss Over 2.5 Years in Knee Osteoarthritis
Authors: Nicholas M. Brisson, Anthony A. Gatti, Philipp Damm, Georg N. Duda, Monica R. Maly
Journal: Arthritis & Rheumatology (2021)

Objective The relationship between in vivo knee load predictions and longitudinal cartilage changes has not been investigated. We undertook this study to develop an equation to predict the medial tibiofemoral contact force (MCF) peak during walking in persons with instrumented knee implants, and to apply this equation to determine the relationship between the predicted MCF peak and cartilage loss in patients with knee osteoarthritis (OA). Methods In adults with knee OA (39 women, 8 men; mean ± SD age 61.1 ± 6.8 years), baseline biomechanical gait analyses were performed, and annualized change in medial tibial cartilage volume (mm 3 /year) over 2.5 years was determined using magnetic resonance imaging. In a separate sample of patients with force‐measuring tibial prostheses (3 women, 6 men; mean ± SD age 70.3 ± 5.2 years), gait data plus in vivo knee loads were used to develop an equation to predict the MCF peak using machine learning. This equation was then applied to the knee OA group, and the relationship between the predicted MCF peak and annualized cartilage volume change was determined. Results The MCF peak was best predicted using gait speed, the knee adduction moment peak, and the vertical knee reaction force peak (root mean square error 132.88N; R 2 = 0.81, P &lt; 0.001). In participants with knee OA, the predicted MCF peak was related to cartilage volume change (R 2 = 0.35, β = −0.119, P &lt; 0.001). Conclusion Machine learning was used to develop a novel equation for predicting the MCF peak from external biomechanical parameters. The predicted MCF peak was positively related to medial tibial cartilage volume loss in patients with knee OA.
Late Retrieval of the Leadless Micra Transcatheter Pacemaker System
Authors: Kentaro Minami
Journal: Clinical Cardiology and Cardiovascular Interventions (2021)

Aim: We report our single-center experience with the retrieval and replacement of the chronically implanted Micra transcatheter pacing system (TPS). Material and Methods: We included 6 patients with an implanted the Micra TPSs who subsequently underwent transvenous method of retrieval at our institution. The indication for device retrieval was pacemaker syndrome in two patients, battery depletion in three patients, and need for upgrade to biventricular pacing in one patient. Results: After an implantation duration of 555 ± 373 days, the overall retrieval success rate was 83.3%, 5 of 6 patients. No procedure-related adverse device events occurred. In the single patient with unsuccessful retrieval, intracardiac echocardiography revealed that the Micra TPS was embedded within the cardiac wall and surrounding tissue. After retrieval, four patients received a new Micra TPS. Conclusions: Late retrieval of an implanted Micra TPS was safe and feasible, which indicates the possibility for their safe and elective replacement with a new leadless pacing device.
P05.11 Preoperative Low Muscle Quality Predicts Poor Outcomes After Surgery for Early-Stage Non-Small Cell Lung Cancer
Authors: A. Kamigaichi, H. Harada, R. Katsumata, K. Hirano, Y. Matsumoto, K. Kawaguchi, Y. Nishimura, K. Miyazaki, S. Shibata
Journal: Journal of Thoracic Oncology (2021)
Deciphering the Role of Intestinal Crypt Cell Populations in Resistance to Chemotherapy
Authors: Carla Frau, Catherine Jamard, Gaspard Delpouve, Gabriela D.A. Guardia, Christelle Machon, Camilla Pilati, Clémentine Le Nevé, Pierre Laurent-Puig, Jérôme Guitton, Pedro A.F. Galante, Luiz O. Penalva, Jean-Noel Freund, Christelle de la Fouchardiere, Michelina Plateroti
Journal: Cancer Research (2021)

Abstract Intestinal crypts are composed of heterogeneous and highly plastic cell populations. Lgr5high-stem cells (SC) are responsible for homeostatic renewal, but other cells can revert to an SC-like phenotype to maintain epithelial integrity. Despite their distinct roles in orchestrating homeostasis, both populations have been designated as the putative “cell-of-origin” of colorectal cancer. However, their respective involvement in the emergence of drug-resistant cancer SCs (CSC), responsible for tumor relapse and associated with poor outcome of colorectal cancer, remains elusive. In this context, the intestinal SC/progenitor-marker Musashi1 (MSI1) is interesting as it plays important functions in intestinal homeostasis and is frequently overexpressed in human colorectal cancer. Therefore, our aims were: (i) to study the impact of chemotherapy on Lgr5-expressing and MSI1-expressing cell populations, (ii) to explore the effect of increased MSI1 levels in response to treatment, and (iii) to evaluate the relevance in human colorectal cancer. Engineered mouse models treated with the therapeutic agent 5-fluorouracil showed that upon increased MSI1 levels, Lgr5high SCs remain sensitive while Lgr5low progenitors reprogram to a drug-resistant phenotype. This resulted in the expansion of an MSI1-expressing cell subpopulation with improved resistance to DNA damage and increased detoxification, typical properties of dormant-CSCs that can reactivate after chemotherapy. Analysis in patients with colorectal cancer revealed a correlation between MSI1 levels and tumor grading, CSC phenotype, and chemoresistance. Altogether, these results shed new light on the biology and plasticity of normal crypt and cancer cell populations and also open new perspectives to target MSI1 to improve chemotherapy outcome. Significance: This study unveils paradoxical roles for MSI1, underlining its importance in facilitating intestinal regeneration upon injury but also unraveling its new function in drug-resistant colorectal cancer stem cells.
<i>ZFTA</i>Translocations Constitute Ependymoma Chromatin Remodeling and Transcription Factors
Authors: Robert Kupp, Lisa Ruff, Sabrina Terranova, Erica Nathan, Stephane Ballereau, Rory Stark, Chandra Sekhar Reddy Chilamakuri, Nadin Hoffmann, Katherine Wickham-Rahrmann, Marcus Widdess, Amir Arabzade, Yanhua Zhao, Srinidhi Varadharajan, Tuyu Zheng, Mohankumar Murugesan, Stefan M. Pfister, Daisuke Kawauchi, Kristian W. Pajtler, Benjamin Deneen, Stephen C. Mack, Katherine E. Masih, Berkley E. Gryder, Javed Khan, Richard J. Gilbertson
Journal: Cancer Discovery (2021)

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MA02.08 Computed Tomography Attenuation Value as Considerable Predictor for Malignancy in Clinical T1 Lung Adenocarcinoma
Authors: Z. Qiu, C. Zhang, H. Wang, R. Fu, F. Cai, X. Chu, S. Liu, J. Su, Y. Wu, W. Zhong
Journal: Journal of Thoracic Oncology (2021)
Targeting chemokines for acute lymphoblastic leukemia therapy
Authors: Zixi Hong, Zimeng Wei, Tian Xie, Lin Fu, Jiaxing Sun, Fuling Zhou, Muhammad Jamal, Qiuping Zhang, Liang Shao
Journal: Journal of Hematology & Oncology (2021)

Abstract Acute lymphoblastic leukemia (ALL) is a hematological malignancy characterized by the malignant clonal expansion of lymphoid hematopoietic precursors. It is regulated by various signaling molecules such as cytokines and adhesion molecules in its microenvironment. Chemokines are chemotactic cytokines that regulate migration, positioning and interactions of cells. Many chemokine axes such as CXCL12/CXCR4 and CCL25/CCR9 have been proved to play important roles in leukemia microenvironment and further affect ALL outcomes. In this review, we summarize the chemokines that are involved in ALL progression and elaborate on their roles and mechanisms in leukemia cell proliferation, infiltration, drug resistance and disease relapse. We also discuss the potential of targeting chemokine axes for ALL treatments, since many related inhibitors have shown promising efficacy in preclinical trials, and some of them have entered clinical trials.
Abstract 3079: The Traditional Mediterranean Diet and Incidence of Diabetes Mellitus Following Myocardial Infarction: The GISSI-Prevenzione Study
Authors: Dariush Mozaffarian, RosaMaria Marfisi, Giacomo Levantesi, Maria Silletta, Luigi Tavazzi, Gianni Tognoni, Franco Valagussa, Roberto Marchioli
Journal: Circulation (2006)

Background While risk factors to prevent CHD in diabetics are well-established, very little is known about risk factors to prevent diabetes in patients with CHD. We tested the hypothesis that a tra...
Comment on “Abuse and Misuse of Pregabalin and Gabapentin: A Systematic Review Update”
Authors: Udo Bonnet, Heath McAnally, Norbert Scherbaum
Journal: Drugs (2021)

We read with great interest the informative and well-conducted systematic review update by Evoy et al. [1] about the risks of gabapentinoid (GP) use (and misuse).The authors concluded that evidence suggests that GP-misuse/abuse is growing and comprises a significant individual and public health threat [1].However, as the authors stated in their Limitations section, the studies included offer limited generalizability [1] due to small sample sizes, mostly retrospective designs and homogenous cohorts of opioid-and other substance-dependent subjects [1].Clinical studies focusing on individuals without past and/or present substance use disorders are clearly lacking.From a standpoint of scale, not only are reported outcomes (frequently surrogate in nature as admitted by the authors [1]) relatively rare, we are aware of only a miniscule number of patients worldwide seeking treatment for GP misuse/addiction.The emergence of a substantial sample seeking detoxification and other addiction medicine services should be a conditio sine qua non for a widely used/misused, allegedly strongly addictive, and thereby potentially
Highly Stretchable, Adhesive, and Self‐Healing Silk Fibroin‐Dopted Hydrogels for Wearable Sensors
Authors: Li Zhao, Jizhong Zhao, Fan Zhang, Zijie Xu, Fan Chen, Yating Shi, Chen Hou, Yicheng Huang, Changjian Lin, Rui Yu, Wenxi Guo
Journal: Advanced Healthcare Materials (2021)

Abstract In recent years, the preparations of flexible electronic devices have attracted great attention. Here, a simple one‐pot method of thermal polymerization is introduced to fabricate silk fibroin‐dopted hydrogels (SFHs), which are both chemically and physically cross‐linked by acrylamide (AM), acrylic acid (AA), and silk fibroin (SF). The addition of SF can effectively enhance the mechanical property of the SFH 12% by 59% compared with SFH 0% . Taking the advantage of its wide working range of stress (about 0.455–568.9 kPa), the SFH can work as a resistance‐type pressure sensor to monitor different human motions. What is more, the excellent adhesion, about 75.17 N m −1 of SFH 46% enables it to fit tightly to other objects during the testing, which significantly reduces the loss of small signals due to poor fit. In addition, the SFH demonstrates excellent self‐healing property without requiring external excitation and a sensitive temperature response in the range of −10 to 60 °C. The SFH is expected to be applied in the field of electronic skin, soft robots, and other flexible electronic products as well as speech recognition.
The Role of non-coding RNA in Cardiac Repair and Regeneration after Myocardial Infarction
Authors: Yongjun Li
Journal: Clinical Cardiology and Cardiovascular Interventions (2021)

Myocardial infarction (MI), one of the cardiovascular diseases (CVDs) with high incidence and mortality rate, seriously endangers human health. The poor ways of fully repairing and regenerating the infarcted myocardium may have an impact on people's life quality, therefore scientists have devoted continuously to exploring the way of myocardial repair after MI so as to strive for a better prognosis of these patients. In recent years, non-coding RNAs (ncRNAs) have been identified and become one of the exciting fields of research in the development of CVDs. In a wide range of areas, more and more research has found that ncRNAs play important roles in myocardial repair. This review mainly introduces some strategies for myocardial repair and the role or mechanism of microRNA (miRNA), long non-coding RNA (lncRNA), circular RNA (circRNA) and circRNA/lncRNA-miRNA-mRNA regulatory axis in the repair of myocardial tissue after MI, in order to build a better understanding and find new therapeutic targets for MI.
Genetic and Epigenetic Fine‐Tuning of <i>TGFB1</i> Expression Within the Human Osteoarthritic Joint
Authors: Sarah J. Rice, Jack B. Roberts, Maria Tselepi, Abby Brumwell, Julia Falk, Charlotte Steven, John Loughlin
Journal: Arthritis & Rheumatology (2021)

Objective Osteoarthritis (OA) is an age‐related disease characterized by articular cartilage degeneration. It is largely heritable, and genetic screening has identified single‐nucleotide polymorphisms (SNPs) marking genomic risk loci. One such locus is marked by the G&gt;A SNP rs75621460, downstream of TGFB1 . This gene encodes transforming growth factor β1, the correct expression of which is essential for cartilage maintenance. This study investigated the regulatory activity of rs75621460 to characterize its impact on TGFB1 expression in disease‐relevant patient samples (n = 319) and in Tc28a2 immortalized chondrocytes. Methods Articular cartilage samples from human patients were genotyped, and DNA methylation levels were quantified using pyrosequencing. Gene reporter and electrophoretic mobility shift assays were used to determine differential nuclear protein binding to the region. The functional impact of DNA methylation on TGFB1 expression was tested using targeted epigenome editing. Results The analyses showed that SNP rs75621460 was located within a TGFB1 enhancer region, and the OA risk allele A altered transcription factor binding, with decreased enhancer activity. Protein complexes binding to A (but not G) induced DNA methylation at flanking CG dinucleotides. Strong correlations between patient DNA methylation levels and TGFB1 expression were observed, with directly opposing effects in the cartilage and the synovium at this locus. This demonstrated biologic pleiotropy in the impact of the SNP within different tissues of the articulating joint. Conclusion The OA risk SNP rs75621460 impacts TGFB1 expression by modulating the function of a gene enhancer. We propose a mechanism by which the SNP impacts enhancer function, providing novel biologic insight into one mechanism of OA genetic risk, which may facilitate the development of future pharmacologic therapies.
P01.17 An Exploratory Study of Associating Factors for Disease Progression After Response to Immune Checkpoint Inhibitor Monotherapy
Authors: O. Kanai, T. Ito, Z. Saito, Y. Yamamoto, K. Fujita, M. Okamura, M. Hashimoto, K. Nakatani, S. Sawai, T. Mio
Journal: Journal of Thoracic Oncology (2021)
P76.18 Tissue- and Plasma-Based Landscape of Resistance to Osimertinib
Authors: S.M. Lim, S. Yang, S.B. Lim, S.G. Heo, S. Daniel, A. Markovets, M. Rafati, C. Park, J. Yun, K. Pyo, M.R. Yun, B. Ahn, M.H. Hong, H.R. Kim, B.C. Cho
Journal: Journal of Thoracic Oncology (2021)
Abstract 17231: Phosphorylation of Mitochondrial Calcium Uniporter Promotes Mitochondrial Calcium Overload in the Heart
Authors: Jessica L Cao, Stephanie M Adaniya, Ulrike Mende, Bong Sook Jhun, Jin O-Uchi
Journal: Circulation (2019)

Objective: Mitochondrial Ca2+ (mtCa2+) overload promotes mitochondrial reactive oxygen species (ROS) generation, cardiomyocyte (CM) apoptosis, and cardiac dysfunction. We previously reported that s...
Improving Health Among Rural Residents in the US
Authors: Katy Backes Kozhimannil, Carrie Henning-Smith
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 256: Post-transcriptional Regulation of Endothelial Nitric Oxide Synthase Expression by Translation Elongation Factor 1-alpha
Authors: Guijun Yan, Aixia Ren, Bei You, Jianxin Sun
Journal: Circulation (2007)

BACKGROUND: Nitric oxide (NO) is a potent cell-signaling molecule that plays important and diverse roles in biological processes. NO produced by endothelial nitric oxide synthesis (eNOS) is critica...
How to Get Started with Single Cell RNA Sequencing Data Analysis
Authors: Michael S. Balzer, Ziyuan Ma, Jianfu Zhou, Amin Abedini, Katalin Susztak
Journal: Journal of the American Society of Nephrology (2021)

Over the last 5 years, single cell methods have enabled the monitoring of gene and protein expression, genetic, and epigenetic changes in thousands of individual cells in a single experiment. With the improved measurement and the decreasing cost of the reactions and sequencing, the size of these datasets is increasing rapidly. The critical bottleneck remains the analysis of the wealth of information generated by single cell experiments. In this review, we give a simplified overview of the analysis pipelines, as they are typically used in the field today. We aim to enable researchers starting out in single cell analysis to gain an overview of challenges and the most commonly used analytical tools. In addition, we hope to empower others to gain an understanding of how typical readouts from single cell datasets are presented in the published literature.
P84.16 Treatment Options for Patients with Brain Metastases in Oncogene-Driven Non-Small Cell Lung Cancer
Authors: Y. Garitaonaindía, M. Martínez, C. Traseira, V. Calvo, F. Franco, A. Collazo, B. Menchen, A. Sánchez, B. Nunez-Garcia, R. Aguado, G. Visedo, A. Morito, M. Blanco Clemente, M. Provencio
Journal: Journal of Thoracic Oncology (2021)