tbuckley/cabot-search huggingface dataset:
In vivo lensless microscopy via a phase mask generating diffraction patterns with high-contrast contours
Authors: Jesse K. Adams, Dong Yan, Jimin Wu, Vivek Boominathan, Sibo Gao, Alex V. Rodriguez, Soonyoung Kim, Jennifer Carns, Rebecca Richards-Kortum, Caleb Kemere, Ashok Veeraraghavan, Jacob T. Robinson
Journal: Nature Biomedical Engineering (2022)

The simple and compact optics of lensless microscopes and the associated computational algorithms allow for large fields of view and the refocusing of the captured images. However, existing lensless techniques cannot accurately reconstruct the typical low-contrast images of optically dense biological tissue. Here we show that lensless imaging of tissue in vivo can be achieved via an optical phase mask designed to create a point spread function consisting of high-contrast contours with a broad spectrum of spatial frequencies. We built a prototype lensless microscope incorporating the 'contour' phase mask and used it to image calcium dynamics in the cortex of live mice (over a field of view of about 16 mm2) and in freely moving Hydra vulgaris, as well as microvasculature in the oral mucosa of volunteers. The low cost, small form factor and computational refocusing capability of in vivo lensless microscopy may open it up to clinical uses, especially for imaging difficult-to-reach areas of the body.
An Unusual False-Positive Uptake of Radioiodine Caused by Posttraumatic Superficial Scab
Authors: Liu Xiao, Lisha Jiang, Rui Huang, Rong Tian, Bin Liu
Journal: Clinical Nuclear Medicine (2021)

A 22-year-old man with a history of recurrent papillary thyroid cancer underwent 131I therapy. Posttherapeutic whole-body scintigraphy was performed 5 days after administration of 5.5 GBq of 131I. The scintigraphy revealed increased activity in the left elbow. On physical examination, the patient had posttraumatic superficial scab at the site of the abnormal activity.
A TEMPORAL EVALUATION AND COMPARISON OF HOSPITALIZATION COSTS OF TRANSCATHETER AORTIC VALVE REPLACEMENT AND SURGICAL AORTIC VALVE REPLACEMENT FROM 2016 TO 2020
Authors: Jonathan Na, James Childress, Michael Sokolow, Paul Han, Gregory Norcross, Jeffrey Fitch, Ian Davis, Ian Welch, Joanne Moon, Keneil Shah, Najdat Bazarbashi, Kevin Clark, Maha Alfaraidhy, Rawan Amir, Kevin Chen, Sahitya Allam, Simin Hossain, Maria Abraham, Zulqarnain Khan, Sonika Patel, Ji Eun Park, Vigyan Bang, Melsjan Shkullaku, Diljon Chahal, Anuj Gupta
Journal: Journal of the American College of Cardiology (2022)
MANAGEMENT OF SYMPTOMATIC CAROTID ARTERY STENOSIS: A META-META ANALYSIS ADDRESSING THE DISCREPANCIES BETWEEN STENTING AND ENDARTERECTOMY
Authors: Karanrajsinh Raol, Nabil K. Al-Kourainy, Aryak Singh, Zachary Elder, Tamam N. Mohamad
Journal: Journal of the American College of Cardiology (2022)
The Never-Ending Quest of Intracerebral Hemorrhage Outcome Prognostication
Authors: J. Claude Hemphill, Wendy Ziai
Journal: JAMA Network Open (2022)

Daniel Woo, MD; Mary E. Comeau, MA; Simone Uniken Venema, MD; Christopher D. Anderson, MD; Matthew Flaherty, MD; Fernando Testai, MD; Steven Kittner, MD; Michael Frankel, MD; Michael L. James, MD; Gene Sung, MD; Mitchell Elkind, MD; Bradford Worrall, MD; Chelsea Kidwell, MD; Nicole Gonzales, MD; Sebastian Koch, MD; Christiana Hall, MD; Lee Birnbaum, MD; Douglas Mayson, MD; Bruce Coull, MD; Marc Malkoff, MD; Kevin N. Sheth, MD; Jacob L. McCauley, PhD; Jennifer Osborne, MSN; Misty Morgan, RN, BSN; Lee Gilkerson, RN, BSN; Tyler Behymer, BS; Elisheva R. Coleman, MD; Jonathan Rosand, MD; Padmini Sekar, MS; Charles J. Moomaw, PhD; Carl D. Langefeld, PhD
An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer
Authors: Brett E. Johnson, Allison L. Creason, Jayne M. Stommel, Jamie M. Keck, Swapnil Parmar, Courtney B. Betts, Aurora Blucher, Christopher Boniface, Elmar Bucher, Erik Burlingame, Todd Camp, Koei Chin, Jennifer Eng, Joseph Estabrook, Heidi S. Feiler, Michael B. Heskett, Zhi Hu, Annette Kolodzie, Ben L. Kong, Marilyne Labrie, Jinho Lee, Patrick Leyshock, Souraya Mitri, Janice Patterson, Jessica L. Riesterer, Shamilene Sivagnanam, Julia Somers, Damir Sudar, Guillaume Thibault, Benjamin R. Weeder, Christina Zheng, Xiaolin Nan, Reid F. Thompson, Laura M. Heiser, Paul T. Spellman, George Thomas, Emek Demir, Young Hwan Chang, Lisa M. Coussens, Alexander R. Guimaraes, Christopher Corless, Jeremy Goecks, Raymond Bergan, Zahi Mitri, Gordon B. Mills, Joe W. Gray
Journal: Cell Reports Medicine (2022)

Mechanisms of therapeutic resistance and vulnerability evolve in metastatic cancers as tumor cells and extrinsic microenvironmental influences change during treatment. To support the development of methods for identifying these mechanisms in individual people, here we present an omic and multidimensional spatial (OMS) atlas generated from four serial biopsies of an individual with metastatic breast cancer during 3.5 years of therapy. This resource links detailed, longitudinal clinical metadata that includes treatment times and doses, anatomic imaging, and blood-based response measurements to clinical and exploratory analyses, which includes comprehensive DNA, RNA, and protein profiles; images of multiplexed immunostaining; and 2- and 3-dimensional scanning electron micrographs. These data report aspects of heterogeneity and evolution of the cancer genome, signaling pathways, immune microenvironment, cellular composition and organization, and ultrastructure. We present illustrative examples of how integrative analyses of these data reveal potential mechanisms of response and resistance and suggest novel therapeutic vulnerabilities.
Zanubrutinib in relapsed/refractory mantle cell lymphoma: long-term efficacy and safety results from a phase 2 study
Authors: Yuqin Song, Keshu Zhou, Dehui Zou, Jianfeng Zhou, Jianda Hu, Haiyan Yang, Huilai Zhang, Jie Ji, Wei Xu, Jie Jin, Fangfang Lv, Ru Feng, Sujun Gao, Haiyi Guo, Lei Zhou, Jane Huang, William Novotny, Pil Kim, Yiling Yu, Binghao Wu, Jun Zhu
Journal: Blood (2022)

Bruton tyrosine kinase (BTK) inhibitor is an established treatment for relapsed/refractory (R/R) mantle cell lymphoma (MCL). Zanubrutinib, a highly selective BTK inhibitor, is approved for patients with MCL who have received ≥1 prior therapy. We report the long-term safety and efficacy results from the multicenter, open-label, phase 2 registration trial of zanubrutinib. Patients (n = 86) received oral zanubrutinib 160 mg twice daily. The primary endpoint was the overall response rate (ORR), assessed per Lugano 2014. After a median follow-up of 35.3 months, the ORR was 83.7%, with 77.9% achieving complete response (CR); the median duration of response was not reached. Median progression-free survival (PFS) was 33.0 months (95% confidence interval [CI], 19.4-NE). The 36-month PFS and overall survival (OS) rates were 47.6% (95% CI, 36.2-58.1) and 74.8% (95% CI, 63.7-83.0), respectively. The safety profile was largely unchanged with extended follow-up. Most common (≥20%) all-grade adverse events (AEs) were neutrophil count decreased (46.5%), upper respiratory tract infection (38.4%), rash (36.0%), white blood cell count decreased (33.7%), and platelet count decreased (32.6%); most were grade 1/2 events. Most common (≥10%) grade ≥3 AEs were neutrophil count decreased (18.6%) and pneumonia (12.8%). Rates of infection, neutropenia, and bleeding were highest in the first 6 months of therapy and decreased thereafter. No cases of atrial fibrillation/flutter, grade ≥3 cardiac AEs, second primary malignancies, or tumor lysis syndrome were reported. After extended follow-up, zanubrutinib demonstrated durable responses and a favorable safety profile in R/R MCL. The trial is registered at ClinicalTrials.gov as NCT03206970.
Estimating the effect of mobility on SARS-CoV-2 transmission during the first and second wave of the COVID-19 epidemic, Switzerland, March to December 2020
Authors: Adrian Lison, Joel Persson, Nicolas Banholzer, Stefan Feuerriegel
Journal: Eurosurveillance (2022)

IntroductionHuman mobility was considerably reduced during the COVID-19 pandemic. To support disease surveillance, it is important to understand the effect of mobility on transmission.AimWe compared the role of mobility during the first and second COVID-19 wave in Switzerland by studying the link between daily travel distances and the effective reproduction number (
Co-administration of treatment for rifampicin-resistant TB and chronic HCV infection: A TBnet and ESGMYC study
Authors: Simone Tunesi, Damien Le Dû, Gina Gualano, Joan-Pau Millet, Aliaksandr Skrahin, Graham Bothamley, Xavier Casas, Delia Goletti, Christoph Lange, Maria Musso, Fabrizio Palmieri, Valérie Pourcher, Christophe Rioux, Alena Skrahina, Nicolas Veziris, Dzmitry Viatushka, Mathilde Jachym-Fréchet, Lorenzo Guglielmetti, Dhiba Marigot-Outtandy, Xavier Lescure, Marie Dubert, Yazdan Yazdanpanah, Eric Caumes, Pascaline Choinier, Elie Haddad, Jakub Kowalczyk, Hélène Laurichesse, Olivier Lesens, Alexandra Aubry, Isabelle Bonnet, Florence Morel
Journal: Journal of Infection (2022)
BIVENTRICULAR MECHANICS OF THE ATHLETE'S HEART: COMPREHENSIVE CHARACTERIZATION USING 3D ECHOCARDIOGRAPHY
Authors: Alexandra Fabian, Adrienn Ujvari, Marton Tokodi, Bálint Károly Lakatos, Orsolya Kiss, Mate Babity, Márk Zámodics, Nora Sydo, Emese Csulak, Hajnalka Vágó, Liliana Szabo, Anna Reka Kiss, Andrea Szűcs, Béla Merkely, Attila Kovács
Journal: Journal of the American College of Cardiology (2022)
QIM22-201: Experiences With Cancer Diagnosis and Treatment in Rural Nebraska: Qualitative Focus Group Analysis
Authors: Kendra L. Ratnapradipa, Jordan Ranta, Krishtee Napit, Lady Beverly Luma, Danae Dinkel, Tamara Robinson, Laura Schabloske, Shinobu Watanabe-Galloway
Journal: Journal of the National Comprehensive Cancer Network (2022)
SYNCOPE FOLLOWING PFIZER-BIONTECH (BNT162B2) VACCINATION UNMASKING BRUGADA SYNDROME
Authors: Mohammad Altermanini, Mhd Baraa Habib, Tahseen Hamamyh, Mouhand Mohamed, Ahmed Abdalla Elyas, Mawahib Elhassan
Journal: Journal of the American College of Cardiology (2022)
What Level of Blood Pressure Is Concerning in Childhood?
Authors: Joseph T. Flynn
Journal: Circulation Research (2022)

The 95th percentile of blood pressure (BP) among healthy children is the currently accepted level used to denote a hypertensive BP reading in pediatric patients. Yet, ample data have emerged showing that the detrimental effects of high BP can be demonstrated at BP levels considered normal by current guidelines. Cardiac, vascular, cognitive, and kidney effects have been shown starting at the 90th percentile in cross-sectional studies, and markers of adult cardiovascular disease appear in longitudinal cohorts whose members had modestly elevated or even normal BP as youth. This review summarizes data that support a lower threshold of concern for children and adolescents, and outlines some of the remaining questions to be answered before a lower threshold BP level could be adopted.
REAL-WORLD EXPERIENCE AND UNMET NEEDS IN THE CURRENT MANAGEMENT OF RECURRENT PERICARDITIS: A PHYSICIAN SURVEY AND MEDICAL CHART REVIEW
Authors: Ajit B. Raisinghani, Leo F. Buckley, Yan Song, Jay Chatfield, Yao Wang, Alexandra Malinowski, Richard Berman, Chujun He, Eric Wu, Dana R. Martin
Journal: Journal of the American College of Cardiology (2022)
IMPACT OF GENDER ON THE ASSOCIATIONS OF EPICARDIAL ADIPOSE TISSUE, CORONARY ARTERY CALCIUM, AND LIVER FIBROSIS IN PREDICTION OF MACE: SUBSTUDY OF THE EISNER TRIAL
Authors: Ramyashree Tummala, Donghee Han, Aryabod Razipour, Andrew Lin, Sean W. Hayes, Louise Thomson, John D. Friedman, Piotr Slomka, Alan Rozanski, Daniel S. Berman, Damini Dey
Journal: Journal of the American College of Cardiology (2022)
SELECTION OF REFERENCE REGION FOR QUANTITATION OF 99MTC-PYROPHOSPHATE UPTAKE IN CARDIAC AMYLOIDOSIS
Authors: Sarah Yeo, Mohammad Alshaheen, Yoshito Kadoya, Clare Carey, Nieve Y. Seeley, Gary R. Small, R. Glenn Wells, Terrence D. Ruddy
Journal: Journal of the American College of Cardiology (2022)
NEUTROPHIL TO LYMPHOCYTE RATIO FOR TRACKING INFLAMMATION AND RECURRENCE IN PATIENTS WITH RECURRENT PERICARDITIS: POST HOC ASSESSMENT OF A PHASE 3 TRIAL, RHAPSODY
Authors: Paul Cremer, Alistair Wheeler, Liangxing Zou, Fang Fang, Bryan Abadie, Joshua Saef, Massimo Imazio, Allan L. Klein, John Frank Paolini
Journal: Journal of the American College of Cardiology (2022)
CARDIOVASCULAR BENEFIT OF EXERCISE IS GREATER IN THOSE WITH ANXIETY AND DEPRESSION
Authors: Hadil Zureigat, Shady Abohashem, Simran Grewal, Azar Radfar, Charbel Gharios, Kenechukwu Mezue, Alexander Cardeiro, Roger Pitman, Lisa Shin, Aaron Baggish, Michael Thomas Osborne, Ahmed A. Tawakol
Journal: Journal of the American College of Cardiology (2022)
Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue
Authors: Marco Rosina, Veronica Ceci, Riccardo Turchi, Chuan Li, Nicholas Borcherding, Francesca Sciarretta, María Sánchez-Díaz, Flavia Tortolici, Keaton Karlinsey, Valerio Chiurchiù, Claudia Fuoco, Rocky Giwa, Rachael L. Field, Matteo Audano, Simona Arena, Alessandro Palma, Federica Riccio, Farnaz Shamsi, Giovanni Renzone, Martina Verri, Anna Crescenzi, Salvatore Rizza, Fiorella Faienza, Giuseppe Filomeni, Sander Kooijman, Stefano Rufini, Antoine A.F. de Vries, Andrea Scaloni, Nico Mitro, Yu-Hua Tseng, Andrés Hidalgo, Beiyan Zhou, Jonathan R. Brestoff, Katia Aquilano, Daniele Lettieri-Barbato
Journal: Cell Metabolism (2022)
The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer
Authors: Hai Wang, Xingyu Rong, Gan Zhao, Yifan Zhou, Yi Xiao, Ding Ma, Xi Jin, Yonglin Wu, Yuchen Yan, Hao Yang, Yuan Zhou, Manning Qian, Chen Niu, Xin Hu, Da-Qiang Li, Qingyun Liu, Yumei Wen, Yi-Zhou Jiang, Chao Zhao, Zhi-Ming Shao
Journal: Cell Metabolism (2022)
<i>JAMA Neurology</i>—The Year in Review, 2021
Authors: S. Andrew Josephson
Journal: JAMA Neurology (2022)

As we look back at 2021 here at JAMA Neurology, we want to once again thank all of our editors, Editorial Board, peer reviewers (who are listed elsewhere), 1 authors, and readers for their incredible support of our journal.We realize that this past year has not been easy for anyone, with challenges relating to the ebb and flow of the COVID-19 pandemic and trying to get back to the many personal and professional activities that were paused in 2020.The fact that so many of you continued to be part of our journal during these unprecedented times stands as a testament to the wonderful network of colleagues who make JAMA Neurology so successful.While 2020 featured a huge number of COVID-19-related submissions, many of which were single observations or preliminary data, 2021 represented a more mature phase of neurological publishing of COVID-19-related articles.The focus turned toward more thorough and longitudinal COVID-19 data or key observations around emerging areas, such as neurological complications of vaccination.At the same time, non-COVID-19related submissions increased as many authors were able to get back to publishing a diverse set of important research topics including clinical trials, some of which were paused during the early stages of the COVID-19 pandemic.Lessons learned from the pandemic at the journal have been numerous and many will continue for years to come, including the ability to provide ultrarapid editorial evaluation, peer review, editing, and publication of select reports that are urgently relevant to clinical practice.The 2707 manuscripts submitted over the past year (Table ), 2-4 including 1949 research manuscripts, represent a decline in numbers from the busy COVID-19-impacted 2020 tally but was about 10% higher than previous records for submissions set the year before.We needed to remain selective in the articles chosen for publication, with an overall acceptance rate of 8% (5% for research manuscripts).Owing to the hard work of all of our reviewers and editorial staff, this large number of submissions did not lead to any increase in turnaround times, with authors receiving a decision in a median of 3 days without peer review and 33 days with peer review.With our impact factor rising again to 18.3, the quality of manuscripts published in JAMA Neurology has never been better.Each week, our team of associate editors meets as a group to discuss every manuscript that has been sent for peer review and is being considered for revision.This meeting is a weekly highlight for the editors and allows us collectively to engage in lively debate.So many times in these meetings, we ask each other the key question of whether a paper will be important and relevant to the broad readership of JAMA Neurology.It is this spirit of putting our readers first in our decision-making that hopefully has made so many of you
Lumbosacral Plexus Neurolymphomatosis
Authors: Karl Bordeau, Marie-Claude Eberlé, Michel Fabbro, Cyril Fersing, Emmanuel Deshayes
Journal: Clinical Nuclear Medicine (2021)

Abstract A 79-year-old man anteriorly treated for primary central nervous system diffuse large B-cell lymphoma with MRI complete response after immunochemotherapy was referred 1 year later for 18 FDG PET/CT because of right persistent lombosciatic radicular pain for 6 months with negative medullary and spine MRI and negative cerebrospinal fluid cytology. Linearly intense uptake was observed in several roots of lumbosacral plexus, highly suggestive of peripheral neurolymphomatosis relapse. No specific treatment was engaged because of rapid decrease of performance status leading to death.
Hydrocortisone to Prevent Bronchopulmonary Dysplasia — Not a Silver Bullet
Authors: Anne Greenough
Journal: New England Journal of Medicine (2022)

Bronchopulmonary dysplasia (BPD) is the most common adverse outcome of very preterm delivery, affecting up to 75% of infants born before 28 weeks of gestation worldwide.1 It is usually diagnosed if an infant remains oxygen dependent at 28 days of age, and severity is determined at 36 weeks of postmenstrual age. BPD was first described in moderately preterm infants with fibrotic lung changes resulting from high oxygen and airway pressure levels. Nowadays, it occurs most commonly in very prematurely born infants with arrest of lung development (alveolar hypoplasia or dysmorphic pulmonary vasculature) and pulmonary inflammation. In the most severely affected, . . .
EARLY INVASIVE STRATEGY AND OUTCOME OF NON-ST- ELEVATION MYOCARDIAL INFARCTION IN PATIENTS WITH CHRONIC KIDNEY DISEASE
Authors: Amir Sharon, Eias Massalha, Boris Fishman, Paul Fefer, Israel Barbash, Amit Segev, Shlomi Matetzky, Victor Guetta, Ehud Grossman, Elad Maor
Journal: Journal of the American College of Cardiology (2022)
Interference of Known or Suspected Endometriosis in Reporting FDG PET/CT Performed in Another Indication
Authors: Sona Balogova, Emile Daraï, Lucia Noskovicova, Ludovit Lukac, Jean-Noël Talbot, Françoise Montravers
Journal: Clinical Nuclear Medicine (2022)

Endometriosis is a common gynecologic condition that may be visualized on 18F-FDG PET/CT and mimic lesions of malignancy. We analyzed the interference of known or suspected endometriosis in reporting 18F-FDG PET/CT performed in another indication.The PET/CT images of 18 women with known (n = 15) or suspected (n = 3) endometriosis were analyzed. Based on clinical follow-up and results of other imaging, biopsy, and/or postsurgical histology, the presence of lesions of endometriosis at the time of 18F-FDG PET/CT was confirmed in 13 of 18 patients (72%). The per-patient positivity rate of 18F-FDG PET/CT was 8/18 (44%; 95% confidence interval, 22%-69%). The patient-based detection rate of 18F-FDG PET/CT in patients with confirmed lesions of endometriosis was 8/13 (62%; confidence interval, 32%-86%). On per-lesion/site basis, 18F-FDG PET/CT detected 11 of 20 sites (55%) of endometriosis. The SUVmax of these lesions/sites ranged between 1.8 and 5.3 (median, 3.8). In 9 of 18 patients (50%), a total of 13 non-endometriosis-related lesions/sites were detected by 18F-FDG PET/CT; their SUVmax ranged between 2.7 and 23 (median, 9.4).The interference of known or suspected endometriosis in reporting 18F-FDG PET/CT performed in another indication was limited but possible and should be kept in mind, even in postmenopausal women, as the oldest patient with 18F-FDG-positive endometriosis was aged 63 years. The lesions of endometriosis showed inconstant 18F-FDG uptake with overlap of SUVmax with low-grade malignancies. In our series, the greatest SUVmax value of lesion of endometriosis was 5.3, somewhat higher than the threshold of 4 previously proposed for identification of malignant transformation of endometriosis.
Schmorl Node Can Cause Increased 68Ga-FAPI Activity on PET/CT
Authors: Junhao Wu, Wenxin Tang, Yingwei Wang, Weidong Gong, Chunyin Zhang
Journal: Clinical Nuclear Medicine (2022)

68Ga-FAPI is a newly developed tumor imaging agent with promising clinical applications. However, benign lesions may also show increased FAPI activity. We accidentally discovered that Schmorl node expressed FAPI activity in a patient with sweat gland cancer. Thus, greater awareness is needed that Schmorl nodes are a potential reason for false-positive uptake on 68Ga-FAPI PET/CT.
TICAGRELOR MONOTHERAPY AFTER PCI ACROSS THE SPECTRUM OF HIGH-RISK PATIENTS: A DEEP DIVE INTO THE TWILIGHT TRIAL
Authors: Johny Nicolas, Philippe Gabriel Steg, Davide Cao, Usman Baber, Samantha Sartori, Zhongjie Zhang, Samin K. Sharma, David J. Cohen, Dominick J. Angiolillo, Tim Collier, Javier Escaned, Robert Gil, Frans Beerkens, Vladimír Džavík, Timothy D. Henry, Kurt Huber, Ran Kornowski, E Magnus Ohman, Mitchell W. Krucoff, Vijay Kunadian, Stuart J. Pocock, Charles Michael Gibson, George D. Dangas, Roxana Mehran
Journal: Journal of the American College of Cardiology (2022)
Determining Sport Concussion Assessment Tool fifth Edition (SCAT5) reliable change in male professional hockey players
Authors: Jared M Bruce, Willem Meeuwisse, Michael G Hutchison, Paul Comper, Ruben J Echemendia
Journal: British Journal of Sports Medicine (2022)

Objectives The purpose of this paper is to provide reliable change metrics and assess the test–retest psychometrics of the Sport Concussion Assessment Tool fifth Edition (SCAT5) in a multilingual sample of professional ice hockey players. Methods The SCAT5 was administered to National Hockey League and American Hockey League male professional ice hockey players as part of the 2018 and 2019 season medical evaluations. We extracted data from an existing clinical database of players who were administered two consecutive baseline evaluations and had no intervening concussions to assess psychometric properties (eg, test–retest reliability) and develop reliable change metrics. Results Overall, 1007 players met inclusion criteria. Players were reassessed on average 344.52 (±62.52) days following their first baseline. Test–retest reliability ranged from r=0.3 to r=0.5. Reliable change metrics for Immediate Memory varied considerably dependent on form order. Significant differences were found between English versus non-English language preference on Immediate Memory and Concentration but not Delayed Memory or the modified Balance Error Scoring System (mBESS). Reliable change indices at the 90% CI were: Symptom Severity (5), Total Symptoms (3), Immediate Memory (3-8), Concentration (2), mBESS (5) and Delayed Memory (2-4). Conclusions Our findings highlight the importance of considering form differences and language preference when determining reliable change from baseline on the SCAT5 in male professional hockey players. The relatively modest test–retest reliability of the measures leaves room for improved psychometric properties and increased sensitivity to concussion in future iterations of the SCAT.