tbuckley/cabot-search huggingface dataset:
Abstract 12369: Adolescents With Eating Disorders Undergo Cardiac Remodeling
Authors: Samuel W Ross, Martin Fisher, Aparna Kulkarni
Journal: Circulation (2021)

Introduction: Patients with eating disorders (ED) such as anorexia and bulimia nervosa are known to have increased cardiac mortality. The exact etiology of this predisposition is unclear. Hypothesis: ED pts have changes in their cardiac structure and function in adolescence that may alter their outcomes. Methods: All ED pts who had an echocardiogram between Jan 2005 - Dec 2020 were included. Patients with congenital heart disease and with poor image quality were excluded. Measurements of systolic and diastolic indices, including mass and volume (5/6 area length method) were made. Standard statistics were performed and pts with BMI &lt; 5% (LBMI) (n=40) were compared to pts with BMI &gt;5% (NBMI, n=36) using Student’s t test. A p value &lt; 0.05 was considered significant. Results: In all, 78/136 pt echos met inclusion criteria. The median age was 16 (12-20) years. The mean BMI was 16.8 + 2.8 kg/sq.m. (LBMI 14.7 + 1.7, NBMI 19.2 + 2.1, p &lt;0.01). Overall, left ventricular mass indexed (LVMI) was 23.2 + 6.8 gm/^height*2.7 with lower LVMI in LBMI (21.8 + 8) than NBMI (24.5 + 5; p=0.05). LV diastolic volumes were higher in LBMI pts (92.1 + 28.9 ml, z score -0.5 + 1.2) than NBMI pts (106 + 26 ml, z score -1.01 + 1.33; p=0.05)(overall 99.4 + 28.2 ml). Concurrently, ejection fraction was higher in LBMI pts (62 + 7% vs NBMI 58 + 5%; p=0.02) (overall 60 + 6%). Diastolic function was within normal range but different between the groups, consisting of mitral valve E/A (LBMI 2.7 + 1.04 vs NBMI 2.3 + 0.7; p=0.05)(overall 2.5 + 0.9), lateral E/e’ (LBMI 5.5 + 1.5 vs NBMI 4.5 + 1.3; p &lt;0.01) (overall 5.0 + 1.5). Left atrial indexed volumes were similar between the groups (LBMI 18 + 6.5 vs NBMI 17.7 + 6.8; p=0.44)(overall 17.9+6.6). Aortic root z scores were higher in LBMI pts (0.01 + 1 vs NBMI -0.4 + 0.8; p=0.03)(overall -0.2 + 0.9). Other abnormalities on echo included mitral valve redundancy/regurgitation in 18% (5 LBMI, 9 NBMI), mild aortic regurgitation in 7% (2 LBMI 4 NBMI) and hemodynamically insignificant pericardial effusions in 9% (6 LBMI, 1O NBMI). Conclusions: Myocardial remodeling occurs in LBMI pts with lower LV mass and higher volumes. Further quantification of myocardial function using speckle tracking and longitudinal follow up may help understand progression and determine the risk for sudden death in these pts.
Abstract 14167: Cardiac Electrophysiologists' Perspectives on Sleep Apnea
Authors: Michael Q Dong, Linda Liu, Kenneth C Bilchick, Nishaki Mehta, Ryan Koene, Selcuk Adabag, Jared Bunch, Adrian M Baranchuk, Younghoon Kwon
Journal: Circulation (2021)

Introduction: Sleep apnea (SA) is a well-recognized and potentially modifiable factor in the pathophysiology of arrhythmias including atrial fibrillation (AF). The purpose of the study was to evaluate cardiac electrophysiologists’ (EP)’s perception about SA and opinions on management. Methods: Based on semi-structured interviews among conveniently sampled EP (N=4) to narrow preliminary areas of interest for investigation, we created a 27-item online Likert scale-based survey instrument entailing several domains using: 1) the relevance of SA in EP practice and familiarity with it, 2) the practice patterns for SA screening and diagnosis, 3) perception on treatments for SA, 4) opinion on the SA care model. The survey was distributed to 89 academic EP programs in the United States and Canada. Results: A total of 105 cardiologists from 49 institutions responded over a 9-month period, including 63% attending EP and 37% EP fellows in training. The majority of respondents agreed that SA is a major concern in their practice (94%) and that they frequently discussed the connection between SA and the risk of arrhythmia with patients (95%). However, nearly half of respondents (42%) indicated insufficient education on SA during training. In addition, many of them (58%) agreed that they would be comfortable managing SA themselves with proper training and education. Many EPs (53%) were not satisfied with the referral process to a sleep specialist in the area where they practice. The majority (66%) of EP physicians agreed that cardiologists should become more involved in the management of SA than they are now. Additionally, majority (86%) agreed that trained advanced practice providers should be able to assess and manage SA. Many identified time constraints, lack of knowledge, and referral process as major barriers to cardiologists becoming more involved in SA care. Conclusions: There is wide recognition by EP of the importance of SA and its relationship with arrhythmia and AF. However, education and incorporation into cardiology practice appears to lag. Future studies examining the impact of integrating SA care delivery in EP practice on patient outcomes, satisfaction of both patients and EP and healthcare cost are needed.
Prognostic Significance of PD1, PD-L1 Expression , Pathological Subtypes and Metabolic Activity on 18F-FDG PET/CT in Refractory /Relapsing Pediatric Hodgkin Lymphoma
Authors: Reham Khedr, Eman Khorshed, Omneya Hassanein, Hany Abdelrahman, Madeeha Elwakil, Mohamed Zaghloul, Asmaa Mohammed Hamoda
Journal: Blood (2021)
TAMI-46. FRIEND AND FOE: RADIATION THERAPY INCREASES GLIOBLASTOMA IMMUNE EVASION VIA EVS
Authors: Markus Schweiger, Bakhos Tannous
Journal: Neuro-Oncology (2021)

Abstract Glioblastoma (GBM) is the most common primary malignant brain tumor and despite optimal treatment, long-term survival is extremely rare. Radiation therapy (RT) leads to successful initial tumor regression but recurrence is inevitable. Previous studies have shown that ionizing radiation leads to a change of immune-related markers on tumor cells. Extracellular vesicles (EVs) are membranous structures secreted by nearly every cell and have been shown drive GBM progression by acting as multifunctional signaling complexes. Here, we show that radiation of GBM cells leads to an altered EV secretion/uptake dynamic, composition, and protein content. Furthermore, we show that EVs secreted by radiated GBM cells modulate the innate (microglia/macrophages) as well as adaptive (T-cells) immune response in the tumor microenvironment. We dissected a novel mechanism by which GBM evades the immune system via EVs following RT, pointing towards novel therapeutic strategies to prevent GBM recurrence.
Germline Runx1 Mutations Induce Inflammation in Hematopoietic Stem and Progenitor Cells and Predispose to Hematologic Malignancies
Authors: Mohd Hafiz Ahmad, Mahesh Hegde, Waihay J. Wong, Andrew Dunbar, Anneliese Carrascoso, Lisa J Garrett, Nayara K Ferreira, Haibo Liu, Rui Li, Benjamin L. Ebert, Ross L. Levine, Julie Zhu, Scot A. Wolfe, Paul P Lui, Lucio H. Castilla
Journal: Blood (2021)
Protein Structure Prediction and Bioinfamatic Analysis of Novel Fusion Gene IKZF1/Pfas in BPDCN
Authors: Yin Le, Qian Yu, Hongkai Zhu, Yi Jiang, Zhihua Wang, Ruijuan Li, Heng Li, Yue Sheng, Zhao Cheng, Hongling Peng
Journal: Blood (2021)
Interim Analysis of the Randomized Phase 1b/3 Study Evaluating the Safety and Efficacy of Tazemetostat Plus Lenalidomide and Rituximab in Patients with Relapsed/Refractory Follicular Lymphoma
Authors: Connie Lee Batlevi, Steven I. Park, Loretta Nastoupil, Tycel Phillips, Jennifer E. Amengual, David Andorsky, Philip Campbell, Pamela McKay, John M. Pagel, John P. Leonard, Jay Yang, Heather O'Connor, Anthony Hamlett, Deyaa Adib, Franck Morschhauser
Journal: Blood (2021)
RBIO-05. THE IMPACT OF STEREOTATIC RADIOSURGERY (SRS) FOR THE RESIDUAL LESIONS OF PINEAL NON-GERMINOMATOUS GERM CELL TUMORS (NGGCTS) FOLLOWING CONVENTIONAL RADIOTHERAPY: A RETROSPECTIVE STUDY
Authors: Mingyao Lai, Juan Li, Qingjun Hu, Shaoqun Li, Linbo Cai
Journal: Neuro-Oncology (2021)

Abstract OBJECTIVE To evaluate the safety and efficacy of stereotatic radiosurgery (SRS) in treating residual lesions of pineal non-germinomatous germ cell tumors (NGGCTs) after conventional radiotherapy. METHODS The patients admitted to Guangdong Sanjiu Brain Hospital from 1 January 2008 to 31 December 2018 who diagnosed with pineal NGGCTs pathologically or clinically were retrospectively analyzed. Among those, the patients received conventional radiotherapy with or without SRS were included. The residual lesions after radiotherapy were defined with a maximum diameter &amp;gt; 10mm. Prognosis related parameters such as local control rate, progress-free survival, overall survival and treatment-related toxicity were determined. RESULTS The median follow-up time was 34 months (range 8-142 months). The objective response rate and disease control rate were 71.4% and 95.2%, respectively. Three-year progression-free survival rate was 85.2% and 3-year total survival rate was 88.0%. The univariate analysis revealed that both age and concurrent chemotherapy were not correlated with the prognosis (P=0.286, 0.824). Partial tumor resection before radiotherapy and chemotherapy, AFP &amp;gt;500ng/ml, and no more than 4 cycles of adjuvant chemotherapy were poor prognostic factors (P=0.037, 0.010, 0.006). Moreover, no acute radiation response was observed after treatment with SRS. Only 1 out of 27 patients (3.7%) had brain neurotoxicity related to a prolonged course of radiochemotherapy. CONCLUSION SRS for residual lesions of NGGCTs following conventional radiotherapy appears to be well tolerant and improved local control. However, the therapeutic efficacy of conventional radiotherapy combined with SRS warrants further investigations in a large-scale randomized controlled clinical trials.
Abstract 13904: Associations of the Ankle Brachial Index With Functional Decline According to Presence or Absence of Diabetes
Authors: Matthew E Gold, Lu Tian, Michael H Criqui, Luigi Ferrucci, Jack Guralnik, Melina R KIBBE, Lingyu Li, Robert Sufit, Lihui Zhao, Mary M McDermott, Tamar S Polonsky
Journal: Circulation (2021)

Introduction: Among patients with peripheral artery disease (PAD), there is an inverse association between the ABI and the risk of functional decline. Whether the association is consistent for adults with vs without diabetes is unknown. Methods: Adults with PAD (ABI&lt;0.90) were identified from vascular labs and outpatient clinics from 4 Chicago-area hospitals in a pooled analysis of 4 observational studies. Every 6-12 months participants completed the six-minute walk (6MW) and were asked about mobility loss (becoming unable to walk up and down a flight of stairs or walk ¼ mile without help). Mixed-effects linear regression analysis with a subject-specific random intercept was used to calculated annual change in 6MW, stratified by diabetes status. Cox proportional hazards models were used to estimate the risk of mobility loss, a decline in 6MW ≥20m or having to stop during the 6MW, per unit increment of ABI (1 unit=0.15). Analyses were adjusted for age, sex, race, study cohort and comorbidities. Results: Among 1,135 patients with PAD, 409 (36%) had diabetes. Mean ABI was similar between groups (0.64 with diabetes, 0.65 without diabetes, p=0.4). Compared to those without diabetes, those with diabetes were older (71.4 vs 68.6, p&lt;0.001) and had a higher BMI (30.5 kg/m 2 vs 27.3 kg/m 2 ). Mean follow-up was 3.3 years. At baseline those with diabetes had a shorter 6MW distance (320.2m vs 356.1m, p&lt;0.001) and over follow-up had a faster rate of annual decline (-20m vs -14.5m, p&lt;0.001). Among adults without diabetes the ABI was associated with stopping during the 6MW, mobility loss and a decline in 6MW ≥20m (Table); among adults with diabetes ABI was only associated with stopping during the 6MW. Conclusions: Among adults with PAD, those with diabetes had worse functional capacity at baseline and faster decline than those without diabetes. Lower ABI values were associated with faster functional decline among adults with PAD, but this association was less consistent among adults with diabetes.
Abstract 10903: Cardiovascular Morbidity Associated with Monoclonal Gammopathy of Undetermined Significance - A Danish Nationwide Study
Authors: Brian Schwartz, Morten Schou, Frederick Ruberg, Dane Rucker, Jihoon Choi, Omar Siddiqi, Lars Kober, Gunnar Gislason, Christian Torp-Pedersen, Charlotte Andersson
Journal: Circulation (2021)

Introduction: Case reports and smaller observational studies have suggested an association between monoclonal gammopathy of undetermined significance (MGUS) and various cardiovascular diseases. We aimed to explore the association of MGUS with a broad spectrum of incident cardiovascular disease further, using the Danish nationwide administrative databases. Methods: Between 1995-2018, all patients eighteen years and older with MGUS were matched (10:1) with controls from the general population based on age and sex. Patients with a diagnosis of multiple myeloma were excluded. Incident cardiovascular diseases were identified using ICD coding. Hazard ratios for cardiovascular outcomes were calculated using Cox proportional hazard regression. Results: Patients with MGUS (n= 8,445, mean age 69.9 years, 51.3% male) had a higher risk of developing most cardiovascular diseases after multivariable adjustment, including heart failure (HR 1.65, 95% CI 1.51-1.81), atrial fibrillation (HR 1.47, 95% CI 1.37-1.58), acute myocardial infarction (HR 1.24, 95% CI 1.08- 1.43), stroke (HR 1.25, 95% CI 1.12-1.40), aortic aneurysm (HR 1.49, 95% CI 1.23-1.80), aortic stenosis (HR 1.72, 95% CI 1.52-1.96), aortic regurgitation (HR 1.70, 95% CI 1.36-2.12), conduction disease (HR 1.52, 95% CI 1.25-1.82), pericarditis (HR 1.62, 95% CI 1.03-2.55), peripheral arterial disease (HR 1.86, 95% CI 1.61-2.14), cor pulmonale (HR 2.32, 95% CI 1.76-3.06), venous thromboembolism (HR 1.29, 95% CI 1.12-1.48), and implantation of a cardiac pacemaker or defibrillator (HR 1.34, 95% CI 1.14-1.59). Conclusions: MGUS is associated with a broad spectrum of cardiovascular diseases, with somewhat greater risk estimates observed for cardiovascular disorders that have previously been associated with infiltrative diseases (such as heart failure, pulmonary hypertension, aortic valvular disease, atrial fibrillation, and conduction abnormality) than for atherosclerotic and thrombotic disorders. Further studies are warranted to understand the underlying mechanisms.
BIOM-02. LEPTOMENINGEAL DISEASE SECONDARY TO MELANOMA: UPDATES ON THE VALIDITY OF THE VERIDEX CELLSEARCH SYSTEM
Authors: yolanda Pina, Sepideh Mokhtari, Youngchul Kim, Brittany Evernden, Nam Tran, Inna Smalley, Nikhil Khushalani, Vincent Law, John Puskas, Gisela Caseres, Michael Vogelbaum, Keiran Smalley, Edwin Peguero, Peter Forsyth
Journal: Neuro-Oncology (2021)

Abstract BACKGROUND Leptomeningeal disease (LMD) is devastating with a median survival of 8-10 weeks without treatment. LMD affects approximately 5% to 25% of melanoma patients. Its pathophysiology remains unknown and effective treatments are virtually non-existent. The primary aim of this study was to evaluate the validity of Veridex CellSearch® System (VCS) compared to Gold Standard test (i.e., CSF cytology). MATERIALS AND METHODS A retrospective chart review was performed of subjects with suspected LMD from melanoma enrolled in the MCC 19332/19648 at Moffitt Cancer Center. Patients underwent standard of care with different treatments as deemed appropriate by treating physician. CSF samples were obtained from lumbar punctures, surgeries, and Ommaya reservoir. CSF was evaluated for quantification of CSF circulating tumor cells (CTCs) with the Veridex CellSearch® System (VCS). RESULTS Forty-eight patients were identified with melanoma as primary tumor, ages 29-80. Twenty-seven had LMD (median age 62) with median KPS 70. N=19 (70%) were diagnosed radiographically and n=5 (19%) with CSF cytology; n=14 (54%) had positive cytology on first LP. From 24 patients with LMD who underwent VCS, n=22 (92% patients had positive CSF CTCs. Number of CTCs/mL CSF was significantly higher in patients with LMD versus in patients without LMD (mean SD 227.6 vs. 0.07, p &amp;lt; 0.001). VCS sensitivity and specificity was analyzed. AUC was 0.515, with TPR 0.250 and FPR 0.286. CSF analysis and treatments were described. The median survival of those with LMD was 2.7 months. CONCLUSION These results indicate the potential value of the VCS as an additional tool to the gold standard in the diagnosis of LMD in patients with high suspicion of the disease. Future directions involve doing prospective studies to further validate this method, and to better understand this patient population to enhance diagnostic tools and management of LMD.
Abstract 13790: Long-Term Mortality After Acute Myocardial Infarction According to Presence of Modifiable Risk Factors
Authors: Etienne Puymirat, Mohamed El Kharchi, Victoria Tea, Jean Ferrieres, Francois Schiele, Tabassome Simon, Nicolas Danchin
Journal: Circulation (2021)

Introduction: Acute myocardial infarction (AMI) in the absence of modifiable risk factors (MRF) might have a poorer outcome. Methods: we assessed long-term survival in the FAST-MI program (3 nationwide French prospective surveys carried out 5 years apart from 2005 to 2015, consecutively including STEMI and NSTEMI patients ≤48 hours from onset, over 1-month periods), according to presence/absence of MRF (current smoking, hypertension, diabetes, obesity or hypercholesterolemia/statin use). Results: Of 13,310 patients included, 9,599 had no history of CAD, of whom 1503 (15.6%) had no MRF; they were older (66 ± 13 vs 64 ± 14 years, P&lt;0.001) with similar GRACE score (141 ± 33 vs 140 ± 36, P=0.54) and LVEF (52 ± 11 vs 53 ± 11, P=0.17), were more frequently men (74 vs 70%, P=0.001) and had more often STEMI (63 vs 58%, P&lt;0.001). Use of coronary angiography and PCI did not differ, 1-vessel disease was more common in patients without MRF (58 vs 52%, P&lt;0.001); at discharge, statin (90 vs 90.5%; moderate/high dose 69 vs 67%), dual antiplatelet (84 vs 85%) and beta-blocker (85 vs 84%) use did not differ, while fewer received ACEi or ARBs (72 vs 75%, P=0.03). At a mean follow-up of 54 months, survival was higher in patients without MRF (88 vs 84%, P&lt;0.001); NSTEMI patients (89 vs 81%, P&lt;0.001), STEMI patients (88 vs 86%, P=0.21) (Figure). After adjustment on baseline variables, absence of MRF was not associated with long-term mortality (HR 0.88, 95%CI 0.72-1.09); however, when also including early management, LVEF and CAD extent in the model, absence of MRF was associated with lower mortality (HR 0.76, 95%CI 0.62-0.92, P&lt;0.001). Conclusion: the management of patients with AMI is very similar, whether they have MRF or not. Long-term survival does not differ among patients with or without MRF. After taking into account early management, however, presence of MRF is associated with worse outcome, suggesting that more intensive treatment might be needed when AMI occurs in patients with documented risk factors.
Abstract 11211: Guideline Directed Medical Therapy After Peripheral Vascular Intervention and One-Year Mortality in Patients with Peripheral Artery Disease in the Vascular Quality Initiative Medicare Linked Database
Authors: Jeremy B Provance, Kim G Smolderen, Jialin Mao, Philip P Goodney, Peter Henke, Art Sedrakyan, Pragati Bogra, Carlos Mena-hurtado
Journal: Circulation (2021)

Introduction: Guideline directed medical therapy (GDMT) for patients with peripheral artery disease (PAD) includes statin, antiplatelet, ACE inhibitors (angiotensin converting enzyme inhibitors) and ARBs (angiotensin-receptor blockers) therapy if hypertensive. Undertreatment with GDMT is still common, and therefore we sought to quantify the association of receiving GDMT vs. not and subsequent mortality in patients undergoing peripheral vascular interventions (PVIs). Methods: The Vascular Quality Initiative linked with Medicare claims data through the VISION platform and contains data for PVIs between 2010 and 2018. Patient-level GDMT at discharge following the index PVI was defined as documentation of all of the following: statin, antiplatelet, and ACE/ARB therapy if hypertensive. Patients with less than three GDMT medications were the comparator. Mortality follow-up was censored to 12 months. Kaplan Meier curves were constructed for one-year mortality. The association between the receipt of GDMT following undergoing a PVI and mortality was quantified with a Cox proportional hazards model, adjusting for demographics, clinical history, and disease severity. Results: A total of 29,676 patients undergoing PVI were analyzed. Of those, 42.2% were female and the mean age was 71.9 (± 10.3) years. GDMT was administered in 64.9% of discharges. One-year mortality rates for those receiving no GDMT vs. complete GDMT was 23.4% vs. 17.3% (P &lt; 0.001) (Figure 1). Not being on GDMT was associated with an increased risk of mortality (Unadjusted HR = 1.24, 95% confidence interval [CI 95%] 1.21-1.27; Adjusted HR = 1.22, 95% CI 1.19-1.25). Conclusions: Over a third of patients did not have documented GDMT after discharge for PVI, which was associated with an increased risk of mortality. There is a potential opportunity to improve outcomes for patients with PAD, who are at an increased risk of cardiovascular diseases, by improving adherence to evidence-based medical therapy.
Abstract 9577: Resting Energy Expenditure is Important Factor to Predict Cardiac Mortality in Chronic Heart Failure
Authors: Takamasa Sato, Akiomi Yoshihisa, Takafumi Ishida, Yasuchika Takeishi
Journal: Circulation (2021)

Introduction: Parameters derived from cardiopulmonary exercise testing (CPX) including peak oxygen consumption (VO 2 ) are important prognostic factors in patients with chronic heart failure (CHF). However, all patients with CHF cannot undergo CPX because of such as exercise intolerance. On the other hands, resting parameters derived from respiratory gas analyzer including resting energy expenditure (REE) could be easily measured and clinical significance of these parameters had not been fully elucidated in patients with CHF. We aimed to determine the prognostic impact of REE in patients with CHF. Methods: A total of 1185 consecutive CHF patients underwent CPX were enrolled. The subjects of this study were divided into two groups according to median REE and we compered the clinical characteristics between two groups. Also, we examined the value of REE (Weir’ formula: 3.941resting VO 2 +1.106resting VCO 2 ) to predict cardiac mortality in CHF patients. Results: In all subjects, 966 were males, median age was 63 years. Median resting VO 2 was 236 ml/min, median resting VCO 2 was 222 ml/min and median REE was 1178 kcal/day. Patients with low REE (&lt;1178 kcal/day) were older and had higher prevalence of female and anemia, lower body mass index (BMI), more impaired renal function, lower parameters of nutrition such as serum total protein and albumin, higher levels of plasma type-B natriuretic peptide, lower resting VO 2 and lower resting VCO 2 and lower peak VO 2 than those with high REE ( &gt; 1178 kcal/day). But left ventricular ejection fraction was similar between two groups. Patients with low REE had significantly higher rates of cardiac death, all cause death and composite cardiac events (cardiac death and re-hospitalization due to worsening heart failure) than those with high REE. Furthermore, REE was the independent predictor of cardiac death, all-cause death and composite cardiac events in the Cox proportional hazard analysis after adjusting for cofounding variables including peak VO 2 . Conclusions: REE as well as peak VO 2 is important predictor of cardiac mortality in patients with CHF.
PF-114 in Patients Failing Prior Tyrosine Kinase-Inhibitor Therapy Including <i>BCR::ABL1</i>T315I
Authors: Anna G. Turkina, Olga Vinogradova, Elza Lomaia, Evgeniya Shatokhina, Oleg A. Shukhov, Andrey Zaritskey, Ekaterina Yu. Chelysheva, Dzhariyat Shikhbabaeva, Irina Nemchenko, Anna Petrova, Anastasiya Bykova, Vasily Shuvaev, Nadia Siordia, Jorge E. Cortes, Robert Peter Gale, Michele Baccarani, Oliver Ottmann, Ilya Mikhailov, Fedor Novikov, Veronika Shulgina, Ghermes Chilov
Journal: Blood (2021)