tbuckley/cabot-search huggingface dataset:
Medical Humanities
Authors: Rita Charon
Journal: Annals of Internal Medicine (2002)

Medical Writings: Book Notes16 July 2002Medical HumanitiesRita Charon, MD, PhDRita Charon, MD, PhDCollege of Physicians and Surgeons of Columbia University, New York, New York.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-2-200207160-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Evans M, Finlay IG, eds. 292 pages. London: BMJ; 2001. $39.95. ISBN 0727916106. Order at www.bmjbooks.com.Field of medicine: Humanities and medicine, medical ethics, and narrative medicine.Format: Softcover book.Audience: Physicians, bioethicists, humanities scholars who work in medical settings, specialists in patients' experiences of illness and the doctor–patient relationship, and students in health professions.Purpose: To articulate the goals, justification, conceptual frameworks, and practice of medical humanities as it has developed in the United Kingdom.Content: Sixteen essays divided into sections devoted to philosophical, pedagogic, and clinical dimensions of humanities and medicine. The authors include U.K. primary care physicians, ... Author, Article, and Disclosure InformationAffiliations: College of Physicians and Surgeons of Columbia University, New York, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 16 July 2002Volume 137, Issue 2Page: 148KeywordsAntibodiesHabitsMedical educationMedical ethicsMedical ethics, humanities, and educationPatientsPrimary care physiciansSurgeons ePublished: 16 July 2002 Issue Published: 16 July 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Preventives for oxaliplatin-induced peripheral neuropathy in colorectal cancer patients.
Authors: Robert Brooks Hines, Christopher Schoborg, Xiang Zhu, Elizabeth Elgin, Shunpu Zhang
Journal: Journal of Clinical Oncology (2022)

83 Background: For colorectal cancer patients treated with the chemotherapy drug oxaliplatin, oxaliplatin-induced peripheral neuropathy (OIPN) is a serious side effect. We conducted an observational comparative effectiveness study to evaluate whether several potential preventives reduced the rate of OIPN diagnosis in the two years following chemotherapy initiation. Methods: This was a retrospective cohort study that utilized the Surveillance, Epidemiology, and End Results database combined with Medicare claims (SEER-Medicare). Eligible patients were diagnosed with colorectal cancer between 2007-2015, 66 years of age or older, and received at least two cycles of oxaliplatin. We used two definitions to denote diagnosis of OIPN: OIPN 1 (diagnosis codes specific to CIPN) and OIPN 2 (additional codes for peripheral neuropathy). Multinomial propensity score weighting was used to balance potential confounders. The Fine-Gray subdistribution hazards model was used to perform a competing risk, time to event analysis for diagnosis of OIPN. Results: There were 4,482 subjects analyzed for the outcome of OIPN 1 (n = 477, 10.1%), and 4,561 for OIPN 2 (n = 1,191, 26.1%). Duloxetine, venlafaxine (marginally significant for OIPN 1), opioids, and minocycline were associated with a decreased rate of OIPN according to both definitions. In addition, memantine and neuromuscular therapy were associated with a decreased rate of OIPN 1 but not OIPN 2. Gabapentin and pregabalin exposure was associated with an increased rate of OIPN diagnosis according to both definitions. Mixed results were obtained for nortriptyline and cannabinoids. Conclusions: This study revealed several potentially effective preventive options for OIPN in colorectal cancer patients receiving oxaliplatin. A limitation of this study is the observational design which cannot directly inform treatment guidelines. However, evidence from this study may serve as preliminary data to support a future randomized clinical trial.[Table: see text]
The Obligation of Members of the American Medical Association to Subscribe to or Sign the Constitution, By-Laws and Code of Ethics, as a Condition of Registration.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Host-Tumor Balance Factors Explored
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"ORIGINAL" WORK AND THE AMERICAN MEDICAL ASSOCIATION.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Face masks: all for one and one for all
Authors: None The Lancet Respiratory Medicine
Journal: The Lancet Respiratory Medicine (2021)

On March 2, 2021, over a year into the pandemic, Texas Governor Greg Abbott joined 15 other states in the USA and lifted the mask mandate, stating that with vaccines being rolled out and case numbers falling it was time. It was met with grave concern from Federal health officials who feel it is too early to lift restrictions, with case numbers still worryingly high and new, potentially more contagious, variants emerging.
A mutation in the methylenetetrahydrofolate reductase gene is associated with increased risk of cardiovascular events in hypertensive patients Thomas K. Makris, Antonios N. Hatzizacharias, Panagiota G. Krespi, George Anastasiadis, George A. Stavroulakis, Argyri Gialeraki, Emmanuel Chronakis, Nicolaos A. Chatzizacharias, Michael K. Kyriakidis. LAIKON General Hospital, Athens, Greece
Journal: Journal of the American College of Cardiology (2001)
GW28-e0966 A study on the mechanism of the NF-κB in Ginsenoside Rb1 against the intrinsic aging of mouse brain
Authors: Bin Zhou, Lin Wu, Shujie Yu, Dinghui Liu, Min Wang, Yesheng Ling, Yong Liu, Baoshun Hao, Lin Chen, Xiaoxian Qian
Journal: Journal of the American College of Cardiology (2017)
Plant-based diets and incident cardiovascular disease and all-cause mortality in African Americans: A cohort study
Authors: Leah J. Weston, Hyunju Kim, Sameera A. Talegawkar, Katherine L. Tucker, Adolfo Correa, Casey M. Rebholz
Journal: PLoS Medicine (2022)

Background Prior studies have documented lower cardiovascular disease (CVD) risk among people with a higher adherence to a plant-based dietary pattern. Non-Hispanic black Americans are an understudied group with high burden of CVD, yet studies of plant-based diets have been limited in this population. Methods and findings We conducted an analysis of prospectively collected data from a community-based cohort of African American adults ( n = 3,635) in the Jackson Heart Study (JHS) aged 21–95 years, living in the Jackson, Mississippi, metropolitan area, US, who were followed from 2000 to 2018. Using self-reported dietary data, we assigned scores to participants’ adherence to 3 plant-based dietary patterns: an overall plant-based diet index (PDI), a healthy PDI (hPDI), and an unhealthy PDI (uPDI). Cox proportional hazards models were used to estimate associations between plant-based diet scores and CVD incidence and all-cause mortality. Over a median follow-up of 13 and 15 years, there were 293 incident CVD cases and 597 deaths, respectively. After adjusting for sociodemographic characteristics (age, sex, and education) and health behaviors (smoking, alcohol intake, margarine intake, physical activity, and total energy intake), no significant association was observed between plant-based diets and incident CVD for overall PDI (hazard ratio [HR] 1.06, 95% CI 0.78–1.42, p- trend = 0.72), hPDI (HR 1.07, 95% CI 0.80–1.42, p- trend = 0.67), and uPDI (HR 0.95, 95% CI 0.71–1.28, p- trend = 0.76). Corresponding HRs (95% CIs) for all-cause mortality risk with overall PDI, hPDI, and uPDI were 0.96 (0.78–1.18), 0.94 (0.76–1.16), and 1.06 (0.86–1.30), respectively. Corresponding HRs (95% CIs) for incident coronary heart disease with overall PDI, hPDI, and uPDI were 1.09 (0.74–1.61), 1.11 (0.76–1.61), and 0.79 (0.52–1.18), respectively. For incident total stroke, HRs (95% CIs) for overall PDI, hPDI, and uPDI were 1.00 (0.66–1.52), 0.91 (0.61–1.36), and 1.26 (0.84–1.89) ( p- trend for all tests &gt; 0.05). Limitations of the study include use of self-reported dietary intake, residual confounding, potential for reverse causation, and that the study did not capture those who exclusively consume plant-derived foods. Conclusions In this study of black Americans, we observed that, unlike in prior studies, greater adherence to a plant-based diet was not associated with CVD or all-cause mortality.
Effects of angiotensin II type 1 receptor blockade and angiotensin converting enzyme inhibitor on the ventricular remodeling after myocardial infarction- with special references to sarcoplasmic reticulum and its mRNA Elichi Geshi, Takashi Katagiri. Third Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
Journal: Journal of the American College of Cardiology (2001)
DEATHS
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pravastatin reduces major coronary events in patients with low levels of both high-density lipoprotein cholesterol and low-density lipoprotein cholesterol: Results from the LIPID study David Colquhoun, Ian Marschner, John Simes, Paul Glasziou, Anthony Keech, Harvey White, Philip Barter, Andrew Tonkin, For the LIPID Study investigators. NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia, CORE Research, Wesley Medical Centre, Brisbane, Australia
Journal: Journal of the American College of Cardiology (2001)
Abstract P300: Presence of Mental Health Conditions Associated With Greater Adherence to Home-Based Cardiac Rehabilitation
Authors: Nirupama Krishnamurthi, David Schopfer, Mary A Whooley
Journal: Circulation (2018)

Introduction: Patients with mental health conditions have higher rates of ischemic heart disease but have been less likely than those without mental health conditions to participate in traditional (center-based) cardiac rehabilitation programs. We sought to examine the association of mental health conditions with rates of participation in (and completion of) home-based cardiac rehabilitation (HBCR). Methods: The Veterans Health Administration is developing new HBCR programs to improve access for patients with cardiovascular disease who are unable to attend traditional (center-based) programs. Among 323 hospitalized patients who were eligible and referred to cardiac rehabilitation at the San Francisco VA between 8/1/15 and 9/30/16, we evaluated the association of depression and/or PTSD (defined based on manual review of medical records) with participation in and completion of HBCR. Logistic regression models were used to adjust for patient demographics, primary indication for CR and comorbid conditions. Results: Of the 323 eligible patients referred to HBCR, 127 (39%) suffered from depression and/or PTSD. Participation rates were 41% (52/127) in patients with vs. 32% (62/196) in patients without depression or PTSD (p=0.09). Among the 114 patients who agreed to participate in HBCR, 52 (46%) suffered from depression and/or PTSD. Rates of completing 9 or more sessions were 67% (35/52) in patients with vs. 44% (27/62) in patients without depression or PTSD (p=0.01). After multivariable adjustment, patients with depression and/or PTSD had a 3-fold greater odds of completing HBCR than those without depression or PTSD (OR 2.85, 95% CI 1.14- 7.17; p=0.02). Conclusions: Among patients referred to cardiac rehabilitation, those with a history of depression and/or PTSD were equally likely to participate and significantly more likely to complete HBCR than those without depression and/or PTSD. These findings suggest that patients with mental health conditions may be especially likely to benefit from HBCR.
Authors’ Reply To the Letters to the Editor by Puklin et al and by Iyengar and Ligibel
Authors: Samuel Martel, Matteo Lambertini, Evandro de Azambuja
Journal: Journal of the National Comprehensive Cancer Network (2022)

rate of all-grade diarrhea was 75%, with 15% of patients experiencing $7 stools per day requiring hospitalization. 4,5Thus, weight loss in obese ALTTO participants may well be a surrogate indicator of ineffective treatment due to accentuated toxicity leading to treatment discontinuation.This theory is supported by 2 observations: (1) the association between weight loss and worse outcomes was primarily significant in the lapatinib-alone arm in ALTTO, and (2) weight loss was not associated with outcomes in trastuzumabtreated patients in HERA.Information from ALTTO regarding the relationships among weight loss, toxicity, and treatment discontinuation would be helpful in assessing this source of potential confounding.The presence of undiagnosed metastatic disease or other comorbid conditions can also confound analyses of weight change and cancer outcomes.In this analysis of ALTTO, the authors acknowledge that they were unable to discern purposeful versus involuntary weight loss.Prospective randomized control trials are needed to overcome these multiple sources of unavoidable confounding.Should weight loss be approached cautiously in patients with HER2-positive breast cancer as the authors suggest?Given the above considerations, and that lapatinib is not part of standard adjuvant treatment, we would not use these post hoc observational analyses for the basis of clinical recommendations.
UNFAIR TESTS.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The effects of beta blockade on the cardiac ryanodine calcium release channel in an animal model of heart failure Alfonso F. J. Prieto, Steve Reiken, Steve O. Marx, Marta Gaburjakova, Jana Gaburjakova, Jie Wang, Kun Lun He, Geng Hua Yi, Daniel Burkhoff, Andrew R. Marks. Columbia University College of Physicians &amp; Surgeons, New York, NY
Journal: Journal of the American College of Cardiology (2001)
Biochemical Journal, London
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial: Cancer risks from hormone treatment.
Journal: BMJ (1975)

The withdrawal from the market of the oral contraceptives Volidan 21 and Serial 28 was based on work in beagle dogs treated for 7 years with high doses of megestrol acetate. The treated animals developed significantly more tumors than untreated controls. Chlormadinone acetate was withdrawn from clinical use in 1970 on the basis of similar reports. All other progestogens in use in Britain had no effect on the incidence of tumors. The only neoplasm linked with oral contraceptives by clinical evidence is hepatic adenoma. In menopausal and postmenopausal patients estrogen therapy may increase the risk of endometrial uterine cancer. For most young women oral contraception is a compromise between safety and reliability. Serious thromboembolic complications increase with age, cigarette smoking, and hypertension. Patients should be screened for the presence of risk factors and the effects of treatment regularly assessed. In menopausal women, regular monitoring for endometrial cancer is advised. Medical supervision of hormone therapy is needed.
A Pulmonary Embolism Diagnostic Strategy in Patients Hospitalized for COPD Exacerbation—Reply
Authors: David Jiménez, Alvar Agustí, Behnood Bikdeli
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal