tbuckley/cabot-search huggingface dataset:
Computer Systems To Help with Ordering Blood Tests in Primary Care
Journal: Annals of Internal Medicine (2001)

Summaries for Patients20 February 2001Computer Systems To Help with Ordering Blood Tests in Primary CareSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-4-200102200-00005 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Many doctors use computerized medical records. Studies show that linking medical records with special electronic programs and reminders can help doctors order correct tests, medications, and procedures. It is not known, however, which type of computer system helps doctors the most in deciding which routine blood tests to order.Why did the researchers do this particular study?To see which of two versions of a computer-based decision support system would have the greatest effect on the number of routine blood tests ordered by doctors.Who was studied?The ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Assessment of Decision Support for Blood Test Ordering in Primary Care. A Randomized Trial.” It is in the 20 February 2001 issue of Annals of Internal Medicine(volume 134, pp 274-281). The authors are MAM van Wijk, J van der Lei, M Mosseveld, AM Bohnen, and JH van Bemmel.Summaries for Patientsare a service provided by Annalsto help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAssessment of Decision Support for Blood Test Ordering in Primary Care Marc A.M. van Wijk , Johan van der Lei , Mees Mosseveld , Arthur M. Bohnen , and Jan H. van Bemmel Metrics 20 February 2001Volume 134, Issue 4Page: I-80KeywordsComputersComputing systemsElectronic medical recordsHematologic testsRandomized trialsSoftware tools ePublished: 20 February 2001 Issue Published: 20 February 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Numeric Error in Figure 1
Journal: JAMA Psychiatry (2022)

Xabier Calle Sánchez, MS; Dorte Helenius, PhD; Jonas Bybjerg-Grauholm, PhD; Carsten Pedersen, PhD; David M. Hougaard, MD; Anders D. Børglum, PhD; Merete Nordentoft, PhD; Ole Mors, MD; Preben B. Mortensen, DrMedSc; Daniel H. Geschwind, MD; Simone Montalbano, MS; Armin Raznahan, MD; Wesley K. Thompson, PhD; Andrés Ingason, PhD; Thomas Werge, PhD
Comparison between sirolimus-coated and noncoated stent implantation in human coronary arteries Fausto Feres, Marco A. Costa, Alexandre Abizaid, Andrea S. Abizaid, Ibraim M. F. Pinto, Ana C. Seixas, Rodolfo Staico, Luiz A. P. Mattos, Aurea Chaves, Marinella Centemero, Luiz F. L. Tanajura, Robert Falotico, Judith Jaeger, Amanda G. M. R. Sousa, J. Eduardo M. R. Sousa. Institute Dante Pazzanese of Cardiology, S�o Paulo, Brazil
Journal: Journal of the American College of Cardiology (2001)
Imaging for sinusitis
Authors: D. B. Howe
Journal: JAMA (1993)

<h3>To the Editor.</h3> —Dr Mafee<sup>1</sup>responded to a question concerning imaging methods for sinusitis. Mafee's response implied that a CT scan should be the radiologic examination of choice for chronic sinusitis. Our concern arises from the article's perfunctory treatment of the cost differential between CT and conventional radiography, the suggestion that benefit and information content are equivalent, and the absence of a comparison of the radiation doses received from the two imaging methods. The comment "the cost to the patient is somewhat more than for a complete sinus series; however, the difference in cost is well worth the expense because of the amount of information obtained from the screening sinus CT scan" is not a sufficiently thorough analysis of the situation. Sometimes additional information may be obtained from CT evaluation of the paranasal sinuses, but additional information does not invariably have a positive impact on the outcome of the
A Plea for Accuracy
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 258: Pulmonary Overexpression of SERCA2A Improves Electrical Dysfunction and Suppresses Arrhythmias in Monocrotaline-induced Right Ventricular Failure
Authors: Benjamin Strauss, Yassine Sassi, Irene C Turnbull, Carlos Bueno-Beti, Erik Kohlbrenner, Roger J Hajjar, Lahouaria Hadri, Fadi G Akar
Journal: Circulation Research (2017)

Background: Pulmonary Arterial Hypertension (PAH) is a major cause of mortality due, in large part to right ventricular (RV) failure. Its electrophysiological (EP) effects however are poorly defined. Recently, a gene therapy approach targeting SERCA2a (S2A) to the lungs improved RV mechanical function in a rodent PAH model. Whether this approach improves myocardial EP properties remains unknown. Methods: Male Sprague Dawley rats received a subcutaneous injection of monocrotaline (MCT 60mg/kg) leading to PAH induced RV failure. Three wks later, rats underwent intratracheal delivery of aerosolized AAV1.S2A (1E11 gc, N=6) or no treatment (MCT, N=7). Age matched rats served as controls (CTRL, N=5). The EP substrate and risk of VT were assessed using high resolution optical action potential (AP) mapping in ex vivo perfused hearts. Results: MCT (6/7) but not CTRL (0/5) hearts were prone to pacing-induced VT (P&lt;0.01). S2A gene therapy markedly suppressed the incidence of VT to &lt;15% (P&lt;.05 vs MCT). Investigation of the EP substrate revealed complete reversal of slow myocardial conduction in S2A treated compared to untreated MCT rats (Fig A, B) . AP duration (APD) and heterogeneity were increased in MCT and partially reversed by AAV1.S2A. Underlying the rise in heterogeneity was selective APD prolongation on the RV side causing &gt;90 degree clockwise shift in the orientation of the transepicardial gradient, an effect which was not reversed by AAV1.S2A (Fig C arrows) . Conclusion: S2A gene therapy to the lungs ameliorates PAH induced EP remodeling and arrhythmia propensity. Our findings highlight for the first time the utility of a non-cardiac gene therapy approach for arrhythmia suppression.
AAV9/MFSD8 gene therapy is effective in preclinical models of neuronal ceroid lipofuscinosis type 7 disease
Authors: Xin Chen, Thomas Dong, Yuhui Hu, Frances C. Shaffo, Nandkishore R. Belur, Joseph R. Mazzulli, Steven J. Gray
Journal: Journal of Clinical Investigation (2022)

Neuronal ceroid lipofuscinosis type 7 (CLN7) disease is a lysosomal storage disease caused by mutations in the facilitator superfamily domain containing 8 (MFSD8) gene, which encodes a membrane-bound lysosomal protein, MFSD8. To test the effectiveness and safety of adeno-associated viral (AAV) gene therapy, an in vitro study demonstrated that AAV2/MFSD8 dose dependently rescued lysosomal function in fibroblasts from a CLN7 patient. An in vivo efficacy study using intrathecal administration of AAV9/MFSD8 to Mfsd8– /– mice at P7–P10 or P120 with high or low dose led to clear age- and dose-dependent effects. A high dose of AAV9/MFSD8 at P7–P10 resulted in widespread MFSD8 mRNA expression, tendency of amelioration of subunit c of mitochondrial ATP synthase accumulation and glial fibrillary acidic protein immunoreactivity, normalization of impaired behaviors, doubled median life span, and extended normal body weight gain. In vivo safety studies in rodents concluded that intrathecal administration of AAV9/MFSD8 was safe and well tolerated. In summary, these results demonstrated that the AAV9/MFSD8 vector is both effective and safe in preclinical models.
J Coll Gen Practitioners, Dartmouth, England
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
COVID-19 Prolonged in Patients with Cancer
Journal: Cancer Discovery (2021)

Abstract Recent research found that patients with cancer and COVID-19 are susceptible to long-term infection, particularly if they have hematologic cancers or metastatic disease. Patients with prolonged COVID-19 had immune system alterations, such as lymphopenia and T-cell exhaustion, and metabolic abnormalities that may have impaired their ability to fight the virus.
LETTER FROM BOSTON.
Authors: None A. N. B.
Journal: JAMA (1883)

The principal event of medical interest in this city at the present time is the official dedication of the stately building recently erected for the medical department of Harvard University. In a former letter the serious damage to this structure by fire was mentioned, which delayed its opening for four months, but this has now been repaired and great preparations are made for its formal delivery to the faculty. The event promises to be attended with unusual interest from the fact that at the same time a life-size portrait of Prof. Oliver Wendell Holmes is to be unveiled, which is to grace its principal hall, and a bust of Prof. Henry J. Bigelow is to be presented to the college. The most brilliant feature of the literary exercises is expected in the oration which will be delivered by Prof. Holmes, and is supposed to be his last official act in
(Re)Building a Kidney
Authors: Leif Oxburgh, Thomas J. Carroll, Ondine Cleaver, Daniel R. Gossett, Deborah K. Hoshizaki, Jeffrey A. Hubbell, Benjamin D. Humphreys, Sanjay Jain, Jan Jensen, David L. Kaplan, Carl Kesselman, Christian J. Ketchum, Melissa H. Little, Andrew P. McMahon, Stuart J. Shankland, Jason R. Spence, M. Todd Valerius, Jason A. Wertheim, Oliver Wessely, Ying Zheng, Iain A. Drummond
Journal: Journal of the American Society of Nephrology (2017)

(Re)Building a Kidney is a National Institute of Diabetes and Digestive and Kidney Diseases-led consortium to optimize approaches for the isolation, expansion, and differentiation of appropriate kidney cell types and the integration of these cells into complex structures that replicate human kidney function. The ultimate goals of the consortium are two-fold: to develop and implement strategies for in vitro engineering of replacement kidney tissue, and to devise strategies to stimulate regeneration of nephrons in situ to restore failing kidney function. Projects within the consortium will answer fundamental questions regarding human gene expression in the developing kidney, essential signaling crosstalk between distinct cell types of the developing kidney, how to derive the many cell types of the kidney through directed differentiation of human pluripotent stem cells, which bioengineering or scaffolding strategies have the most potential for kidney tissue formation, and basic parameters of the regenerative response to injury. As these projects progress, the consortium will incorporate systematic investigations in physiologic function of in vitro and in vivo differentiated kidney tissue, strategies for engraftment in experimental animals, and development of therapeutic approaches to activate innate reparative responses.
Medicine 1976
Authors: Irwin R. Callen
Journal: JAMA (1977)

The result of the conference is a superb collection of well-written articles most suitable for the continued education of physicians interested in selected advances in medical theory and practice. The authors are generally from England, but the information (with the exception of a few drugs not yet available in the United States) is most applicable here. This book is divided into seven sections and two commemorative lectures. The first section covers immunology, beginning with basic approaches to the cells of the immune system and assessment of immunologic responses in man. Then there follow discussions of immunologic aspects of chronic bacterial infection, persistent virus infections, hepatitis, and respiratory disease, and the relationship of complement deficiency and HLA-B27 antigen to immune disease. The illustrations in this section and throughout the book are of excellent quality. The balance of this book covers advances in neurology, gastroenterology, renal disease, reproductive medicine, and the treatment
Financial support of our growing medical schools
Authors: C. B. Chapman
Journal: JAMA (1968)

Adequate financing of our growing medical schools at a time when the nation is in fiscal turmoil is probably not possible. This is one aspect of the dangerous crisis we have reached in medical education. The other aspect is even more fundamental; it has to do with the educational philosophy on which our projections of fiscal need are based. It is with this feature that I propose to deal. Many groups, within the past year, have come up with estimates of the monetary amounts we now need to grow and develop. About all that these estimates have in common is that they are large—up to $400 million annually. These efforts are of value chiefly in the emphases they place. It is probably not very useful at this time to attempt to deal with detailed breakdowns of the financial aspects of the estimates. The crisis might be nothing more than
New Books
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction to: COVID-19 Myocardial Pathology Evaluation in Athletes with Cardiac Magnetic Resonance (COMPETE CMR)
Journal: Circulation (2021)

a correction is needed.The use of the word "incidence" in the paper was replaced in 3 instances with the word "prevalence.""We report the findings of a larger CMR study to evaluate the prevalence and extent of cardiovascular pathology…" "The prevalence of myocarditis in collegiate athletes after COVID-19 is modest…" "Disparities in volumetrics and LGE prevalence between the COVID-19+ athletes and healthy controls were diminished…"The correction has been made to the current online version of the article, which is available at https://www.ahajournals.org/
HEATED SERUM TO PREVENT INFECTION.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Year Book of the Nose, Throat, and Ear. The Nose and Throat,
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Advanced age is not a contraindication to mitral valve repair Richard Lee, Thoralf M. Sundt, III, Yi Zhang, Marc R. Moon, Michael K. Pasque, Hendrick B. Barner, Ralph J. Damiano, Jr., William A. Gay. Washington University School of Medicine, Division of Cardiothoracic Surgery, Saint Louis, MO
Journal: Journal of the American College of Cardiology (2001)
Association of rare predicted loss-of-function variants of influenza-related type I IFN genes with critical COVID-19 pneumonia
Authors: Qian Zhang, Aurélie Cobat, Paul Bastard, Luigi D. Notarangelo, Helen C. Su, Laurent Abel, Jean-Laurent Casanova
Journal: Journal of Clinical Investigation (2021)

To the Editor: Povysil et al. report that "rare loss-of-function variants in type I IFN immunity genes are not associated with severe COVID-19" (1).We disagree with the authors' interpretation of our data (2) and their own for 6 reasons: (i) Only predicted loss-of-function LOF (pLOF) variants are relevant for comparison between the 2 studies, because, unlike our group, Povysil et al. did not test variants experimentally.The relevant proportion in our data is therefore not 23/659, or 3.5%, but 9/659, or 1.36%; whereas theirs is 1/713, or 0.14%.(ii) Our definitions of "severe/critical" disease are different: we defined critical disease as having severity grades 6-10 according to the WHO scale (3), whereas Povysil et al. restricted their recruitment to grades 7-10 (i.e., excluding patients on high-flow oxygen, who were considered in our study).Their cohort of "mild" cases may therefore have included severe COVID-19 cases (grade 6), such as perhaps the TLR3 pLOF carrier designated as having mild disease.(iii) The controls in the work by Povysil et al. comprised individuals from the general population, without depletion of COVID-19 genetic risk factors, whereas we included paucisymptomatic and asymptomatic infected subjects (grades 1-3) as controls.Consequently, the power computation shown in their Figure 1 is based on an incorrect hypothesis about the odds ratio, which would be expected to be lower when using general population controls (as they did) than when using paucisymptomatic and asymptomatic infected individuals (as we did).(iv) The ethnic origin of the patients differs between the 2 studies: 58% of our 659 patients (and 8 of our 9 pLOF carriers) were European, versus only 10% of their 713 patients with severe disease (and the pLOF carrier was East Asian).(v) Age is a key factor neglected in their comparison: our sample was much younger (mean age, 51.8 years) than theirs (mean, 65.9 years), and 7 of our 9 pLOF carriers were younger than 60 years.We performed a comparison stratified by age (<60 versus ≥60 years), and no significant difference in pLOF proportion was found between the 2 studies, even ignoring the only patient carrying a pLOF they identified (of unknown age): 7/458 in our sample versus 0/192 in their sample (P = 0.11, Fisher's exact test) for patients younger than 60 years, and 2/201 versus 0/521 (P = 0.07) for patients at least 60 years old.(vi) Finally, and crucially, the authors did not exclude patients with autoantibodies against type I IFN, which account for at least 10% of critical cases; these autoantibodies are much more frequent in patients older than 60 years, particularly men (4).