tbuckley/cabot-search huggingface dataset:
Abstract 9253: Proteomic and Functional Assessment of High Density Lipoprotein Subclasses in Acute Coronary Syndromes Subjects as Well as Control Subjects
Authors: Ying Tan, Ting-Rong Liu, Shui-Wang Hu, Di Tian, Zhi-Gang Guo
Journal: Circulation (2012)

Objectives: To explicit whether the functions of HDL subclasses (HDL 2 and HDL 3 ) are impaired in subjects with acute coronary syndromes (ACS). And on top of that, we confirm that alterations in HDL subclasses proteomics may exert an instrumental effect on the occurence of dysfunctional HDL subclasses. Methods: We measured HDL subclasses inflammatory index (HII), paraoxonase (PON) activity and LOOH levels in 30 patients with ACS compared with 30 healthy subjects. Additionally, proteomics was used to monitor changes in the HDL subclasses proteome between controls and ACS subjects. HDL subfractions were isolated by ultracentrifugation and the proteins were separated with 2-D gel electrophoresis and identified with mass spectrometry. Results: Subjects with ACS had higher HII and HDL-LOOH levels compared with controls; Paraoxonase activity in ACS group was significantly lower than that of control group (Table 1). Using proteome analysis, we demonstrated that compared with control group, HDL 3 from subjects with ACS was selectively enriched in 8 proteins (apoA-I, apoA-IV, apoE, apoL1, PON, alpha-1B-glycoprotein, amyloid P-component, fibrinogen gamma chain), and meanwhile ras-related protein Rab-7b was decreased in HDL 3 . Moreover, HDL 2 from ACS group was selectively lower in 10 proteins (apoE, PON, apoA-IV, apoL1, haptoglobin, hemopexin, serotransferrin, complement factorB, fibrinogen gamma chain,ras-related protein Rab-7b); but 2 proteins were increased in HDL 2 (amyloid P-component, alpha-1 antitrypsin). Conclusions: HDL subclasses have less anti-inflammatory and anti-oxidant capacities in ACS patients compared with controls. Moreover, the study also suggest that composition alteration of HDL subfractions may play a pivotal role in the progress of functional HDL subclasses shift to dysfunctional HDL subclasses. Furthermore, this research reveals new proteins in HDL 2 and HDL 3 ; serum amyloid P-component and ras-related protein Rab-7b.
Antiemetic Drugs During Pregnancy: What Can We Learn From Spontaneous Reporting System Database Analyses?—Reply
Authors: Krista F. Huybrechts, Sonia Hernández-Díaz, Brian T. Bateman
Journal: JAMA Pediatrics (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Doctor previously struck off for lying and plagiarism is restored to medical register
Authors: Clare Dyer
Journal: BMJ (2021)

A doctor who was struck off in 2013 for lying and plagiarising others’ work in documents he completed for his GP training has been restored to the medical register at his second attempt.

Fazal Hussain falsely claimed two pharmacy qualifications and wrote his own entries in a multisource feedback form, pretending that the comments were written by a healthcare assistant. He also plagiarised a review of A J Cronin’s novel about the practice of medicine in the 1920s, The Citadel , presenting it as his own thoughts in his reflexive learning log.

The fitness to practise panel that struck him off in 2013 found that he did not demonstrate any insight …
Metallothionein-1G suppresses pancreatic cancer cell stemness by limiting activin A secretion <i>via</i> NF-κB inhibition
Authors: Kai Li, Zhicheng Zhang, Yu Mei, Qingzhu Yang, Shupei Qiao, Cheng Ni, Yao Yao, Xinyuan Li, Mengmeng Li, Dongdong Wei, Wangjun Fu, Xuefei Guo, Xuemei Huang, Huanjie Yang
Journal: Theranostics (2021)

Resistance to chemotherapy is a long-standing problem in the management of cancer, and cancer stem cells are regarded as the main source of this resistance. This study aimed to investigate metallothionein (MT)-1G involvement in the regulation of cancer stemness and provide a strategy to overcome chemoresistance in pancreatic ductal adenocarcinoma (PDAC).
Muscle functional recovery is driven by extracellular vesicles combined with muscle extracellular matrix in a volumetric muscle loss murine model
Authors: Fabio Magarotto, Alberto Sgrò, Agner Henrique Dorigo Hochuli, Marina Andreetta, Michele Grassi, Mattia Saggioro, Leonardo Nogara, Anna Maria Tolomeo, Riccardo Francescato, Federica Collino, Giuseppe Germano, Federico Caicci, Edoardo Maghin, Martina Piccoli, Marcin Jurga, Bert Blaauw, Piergiorgio Gamba, Maurizio Muraca, Michela Pozzobon
Journal: Biomaterials (2021)
Socioeconomic and Administrative Factors Associated with Healthcare Delay and Treatment of Esophageal and Gastric Carcinoma: Experience at a Tertiary Care Centre in a Developing Country
Authors: S. Hassan, L. D, L. Jacob, S. Babu, L. Kn, R. Ah, R. Lk, S. Saldanha, A. Thottian
Journal: Annals of Oncology (2019)
Abstract 15905: Reduced Cardioprotective Action of Adiponectin in High Fat Diet Induced Type II Diabetic Mice and its Mechanisms Involved
Authors: Wei Yi, Yang Sun, Erhe Gao, Xufeng Wei, Wayne Bond Lau, Qijun Zheng, Yajing Wang, Yuexing Yuan, Xiao-Liang Wang, Rong Li, Walter Koch, Xin Ma
Journal: Circulation (2010)

Diabetes increases the morbidity/mortality of ischemic heart disease through incompletely understood mechanisms. Many studies in normal animals have demonstrated that adiponectin (APN) reduces myoc...
MO01.10 Activity of Lurbinectedin in Second-line SCLC Patients Who Are Candidates for Platinum Rechallenge
Authors: V. Subbiah, L. Paz-Ares, B. Besse, K. Zaman, M.A. Sala, J.A. López-Vilariño, C. Fernández, C. Kahatt, M. Siguero, A. Zeaiter, J. Arrondeau, J.-P. Delord, M. Martínez, A. Antón, José M. Trigo, L. Wannesson
Journal: Journal of Thoracic Oncology (2021)
Routine universal testing versus selective or incidental testing for oropharyngeal Neisseria gonorrhoeae in women in the Netherlands: a retrospective cohort study
Authors: Geneviève A F S van Liere, Nicole H T M Dukers-Muijrers, Sophie Kuizenga-Wessel, Petra F G Wolffs, Christian J P A Hoebe
Journal: The Lancet Infectious Diseases (2021)
Proton pump inhibitor use and risk for recurrent Clostridioides difficile infection: a systematic review and meta-analysis
Authors: Kristin M. D'Silva, Raaj Mehta, Michael Mitchell, Todd C. Lee, Vibha Singhal, Marnie Goodwin Wilson, Emily G. McDonald
Journal: Clinical Microbiology and Infection (2021)

<h2>Abstract</h2><h3>Objectives</h3> Proton pump inhibitor (PPI) therapy is a potentially modifiable risk factor for recurrent <i>Clostridioides difficile</i> infection (CDI). Citing an absence of clinical trials, many guidelines do not provide recommendations for addressing PPI management. Our aim was to perform an updated systematic review and meta-analysis evaluating the association between PPI use and recurrent CDI addressing prior methodological limitations. <h3>Methods</h3> Data sources were MEDLINE and EMBASE. Eligible studies were cohort and case–control studies; there were no restrictions on study setting or duration of follow-up. Participants were adults with prior CDI who did or did not receive PPI therapy and were assessed for recurrent CDI. Summary (unadjusted) odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a random effects model. Prespecified subgroup analyses were performed to explore heterogeneity including study design, study quality, duration of follow-up, adjustment for confounders, and outcome definition. <h3>Results</h3> Sixteen studies were included in the meta-analysis, comprising 57 477 patients with CDI, of whom 6870 (12%) received PPIs. The rate of recurrent CDI was 24% in patients treated with PPIs versus 18% in those who were not. A meta-analysis that pooled unadjusted odds ratios demonstrated higher odds of recurrent CDI in patients who received PPIs (OR 1.69, 95%CI 1.46–1.96) versus those who did not. There was moderate heterogeneity between studies (I<sup>2</sup> 56%); however, a sensitivity analysis restricted to studies with 56 days of follow-up substantially reduced the heterogeneity (OR 1.59, 95%CI 1.36–1.85; I<sup>2</sup> 12%). An analysis restricted to multivariate studies that combined adjusted ORs also demonstrated higher odds of recurrent CDI in patients who received PPIs (OR 1.49, 95%CI 1.12–2.00). No publication bias was identified. <h3>Conclusions</h3> We found significantly higher odds of recurrent CDI among users of PPIs that persisted across multiple sensitivity analyses. These results support stronger recommendations for PPI stewardship at CDI diagnosis.
Innate Immune Signal Pathway Activation Induced By Combined Loss of Del(5q) MDS Genes, Tifab and Mir-146a, Accelerates Hematopoietic Stem Cell Exhaustion Driven By Chronic Exposure to a TLR Ligands
Authors: Tomoya Muto, Melinda Varney, Callum Walker, Lyndsey Bolanos, Kathleen Hueneman, Daniel Starczynowski
Journal: Blood (2017)
Animal Model of Pregnancy after Acute Kidney Injury Mirrors the Human Observations
Authors: Jessica Sheehan Tangren, Ravi Thadhani
Journal: Journal of the American Society of Nephrology (2021)

CKD affects 3%–5% of reproductive age women in the United States, and the prevalence is increasing due to trends in obesity and delayed childbearing.[1][1] Women with advanced kidney disease are in the highest-risk groups for complications in pregnancy, including a three- to ten-fold increase in
Ruxolitinib discontinuation syndrome: incidence, risk factors, and management in 251 patients with myelofibrosis
Authors: Francesca Palandri, Giuseppe Alberto Palumbo, Elena Maria Elli, Nicola Polverelli, Giulia Benevolo, Bruno Martino, Elisabetta Abruzzese, Mario Tiribelli, Alessia Tieghi, Roberto Latagliata, Francesco Cavazzini, Micaela Bergamaschi, Gianni Binotto, Monica Crugnola, Alessandro Isidori, Giovanni Caocci, Florian Heidel, Novella Pugliese, Costanza Bosi, Daniela Bartoletti, Giuseppe Auteri, Daniele Cattaneo, Luigi Scaffidi, Malgorzata Monica Trawinska, Rossella Stella, Fiorella Ciantia, Fabrizio Pane, Antonio Cuneo, Mauro Krampera, Gianpietro Semenzato, Roberto Massimo Lemoli, Alessandra Iurlo, Nicola Vianelli, Michele Cavo, Massimo Breccia, Massimiliano Bonifacio
Journal: Blood Cancer Journal (2021)
Broadly effective metabolic and immune recovery with C5 inhibition in CHAPLE disease
Authors: Ahmet Ozen, Nurhan Kasap, Ivan Vujkovic-Cvijin, Richard Apps, Foo Cheung, Elif Karakoc-Aydiner, Bilge Akkelle, Sinan Sari, Engin Tutar, Figen Ozcay, Dilara Kocacik Uygun, Ali Islek, Gamze Akgun, Merve Selcuk, Oya Balci Sezer, Yu Zhang, Gunsel Kutluk, Erdem Topal, Ersin Sayar, Cigdem Celikel, Roderick H. J. Houwen, Aysen Bingol, Ismail Ogulur, Sevgi Bilgic Eltan, Andrew L. Snow, Camille Lake, Giovanna Fantoni, Camille Alba, Brian Sellers, Samuel D. Chauvin, Clifton L. Dalgard, Olivier Harari, Yan G. Ni, Ming-Dauh Wang, Kishor Devalaraja-Narashimha, Poorani Subramanian, Rabia Ergelen, Reha Artan, Sukru Nail Guner, Buket Dalgic, John Tsang, Yasmine Belkaid, Deniz Ertem, Safa Baris, Michael J. Lenardo
Journal: Nature Immunology (2021)
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation
Authors: Martín A. Rivas, Cem Meydan, Christopher R. Chin, Matt F. Challman, Daleum Kim, Bhavneet Bhinder, Andreas Kloetgen, Aaron D. Viny, Matt R. Teater, Dylan R. McNally, Ashley S. Doane, Wendy Béguelin, María Teresa Calvo Fernández, Hao Shen, Xiang Wang, Ross L. Levine, Zhengming Chen, Aristotelis Tsirigos, Olivier Elemento, Christopher E. Mason, Ari M. Melnick
Journal: Nature Immunology (2021)
Introduction to the Theme “Old and New Toxicology: Interfaces with Pharmacology”
Authors: Max Costa, Terrence F. Blaschke, Susan G. Amara, Urs A. Meyer, Paul A. Insel
Journal: The Annual Review of Pharmacology and Toxicology (2021)

The theme of Volume 61 is “Old and New Toxicology: Interfaces with Pharmacology.” Old toxicology is exemplified by the authors of the autobiographical articles: B.M. Olivera's work on toxins and venoms from cone snails and P. Taylor's studies of acetylcholinesterase and the nicotinic cholinergic receptor, which serve as sites of action for numerous pesticides and venoms. Other articles in this volume focus on new understanding and new types of toxicology, including ( a) arsenic toxicity, which is an ancient poison that, through evolution, has caused most multicellular organisms to express an active arsenic methyltransferase to methylate arsenite, which accelerates the excretion of arsenic from the body; ( b) small molecules that react with lipid dicarbonyls, which are now considered the most toxic oxidative stress end products; ( c) immune checkpoint inhibitors (ICIs), which have revolutionized cancer therapy but have numerous immune-related adverse events, including cardiovascular complications; ( d) autoimmunity caused by the environment; ( e) idiosyncratic drug-induced liver disease, which together with the toxicity of ICIs represents new toxicology interfacing with pharmacology; and ( f) sex differences in the development of cardiovascular disease, with men more susceptible than women to vascular inflammation that initiates and perpetuates disease. These articles and others in Volume 61 reflect the interface and close integration of pharmacology and toxicology that began long ago but continues today.
Lymph Node Assessment in Prostate Cancer
Authors: Simon Lennartz, Philipp Täger, David Zopfs, Andra-Iza Iuga, Robert Peter Reimer, Charlotte Zäske, Nils Große Hokamp, David Maintz, Axel Heidenreich, Alexander Drzezga, Carsten Kobe, Thorsten Persigehl
Journal: Clinical Nuclear Medicine (2021)

The aims of this study were to evaluate spectral detector CT (SDCT)-derived iodine concentration (IC) of lymph nodes diagnosed as metastatic and benign in prostate-specific membrane antigen (PSMA) PET/CT and to assess its potential use for lymph node assessment in prostate cancer.Thirty-four prostate cancer patients were retrospectively included: 16 patients with and 18 without lymph node metastases as determined by PSMA PET/CT. Patients underwent PSMA PET/CT as well as portal venous phase abdominal SDCT for clinical cancer follow-up. Only scan pairs with a stable nodal status indicated by constant size as well as comparable prostate-specific antigen (PSA) levels were included. One hundred benign and 96 suspected metastatic lymph nodes were annotated and correlated between SDCT and PSMA PET/CT. Iodine concentration in SDCT-derived iodine maps and SUVmax in ultra-high definition reconstructions from PSMA PET/CT were acquired based on the region of interest.Metastatic lymph nodes as per PSMA PET/CT showed higher IC than nonmetastatic nodes (1.9 ± 0.6 mg/mL vs 1.5 ± 0.5 mg/mL, P < 0.05) resulting in an AUC of 0.72 and sensitivity/specificity of 81.3%/58.5%. The mean short axis diameter of metastatic lymph nodes was larger than that of nonmetastatic nodes (6.9 ± 3.6 mm vs 5.3 ± 1.3 mm; P < 0.05); a size threshold of 1 cm short axis diameter resulted in a sensitivity/specificity of 12.8%/99.0%. There was a significant yet weak positive correlation between SUVmax and IC (rs = 0.25; P < 0.001).Spectral detector CT-derived IC was increased in lymph nodes diagnosed as metastatic in PSMA PET/CT yet showed considerable data overlap. The correlation between IC and SUVmax was weak, highlighting the role of PSMA PET/CT as important reference imaging modality for detection of lymph node metastases in prostate cancer patients.
Corrigendum to “A viscoelastic PEGylated poly(glycerol sebacate)-based bilayer scaffold for cartilage regeneration in full-thickness osteochondral defect” [Biomaterials 253 (2020) 120095]
Authors: Dan Lin, Bolei Cai, Le Wang, Lisha Cai, Zihao Wang, Jirong Xie, Qian-xin Lv, Yuan Yuan, Changsheng Liu, Steve GF. Shen
Journal: Biomaterials (2021)
A microbial metabolite remodels the gut-liver axis following bariatric surgery
Authors: Snehal N. Chaudhari, James N. Luo, David A. Harris, Hassan Aliakbarian, Lina Yao, Donggi Paik, Renuka Subramaniam, Arijit A. Adhikari, Ashley H. Vernon, Ayse Kiliç, Scott T. Weiss, Jun R. Huh, Eric G. Sheu, A. Sloan Devlin
Journal: Cell Host & Microbe (2021)
Overcoming innate immune barriers that impede AAV gene therapy vectors
Authors: Manish Muhuri, Yukiko Maeda, Hong Ma, Sanjay Ram, Katherine A. Fitzgerald, Phillip W.L. Tai, Guangping Gao
Journal: Journal of Clinical Investigation (2021)

The field of gene therapy has made considerable progress over the past several years. Adeno-associated virus (AAV) vectors have emerged as promising and attractive tools for in vivo gene therapy. Despite the recent clinical successes achieved with recombinant AAVs (rAAVs) for therapeutics, host immune responses against the vector and transgene product have been observed in numerous preclinical and clinical studies. These outcomes have hampered the advancement of AAV gene therapies, preventing them from becoming fully viable and safe medicines. The human immune system is multidimensional and complex. Both the innate and adaptive arms of the immune system seem to play a concerted role in the response against rAAVs. While most efforts have been focused on the role of adaptive immunity and developing ways to overcome it, the innate immune system has also been found to have a critical function. Innate immunity not only mediates the initial response to the vector, but also primes the adaptive immune system to launch a more deleterious attack against the foreign vector. This Review highlights what is known about innate immune responses against rAAVs and discusses potential strategies to circumvent these pathways.
An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence
Authors: Eugen Dhimolea, Ricardo de Matos Simoes, Dhvanir Kansara, Aziz Al’Khafaji, Juliette Bouyssou, Xiang Weng, Shruti Sharma, Joseline Raja, Pallavi Awate, Ryosuke Shirasaki, Huihui Tang, Brian J. Glassner, Zhiyi Liu, Dong Gao, Jordan Bryan, Samantha Bender, Jennifer Roth, Michal Scheffer, Rinath Jeselsohn, Nathanael S. Gray, Irene Georgakoudi, Francisca Vazquez, Aviad Tsherniak, Yu Chen, Alana Welm, Cihangir Duy, Ari Melnick, Boris Bartholdy, Myles Brown, Aedin C. Culhane, Constantine S. Mitsiades
Journal: Cancer Cell (2021)
AB0668 CLINICAL CHARACTERISTICS OF RADIOGRAPHIC AND NON RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS IN A GROUP OF TUNISIAN SPONDYLOARTHRITIS
Authors: K. Ben Abdelghani, Y. Gzam, A. Fazaa, S. Miladi, K. Ouenniche, L. Souabni, S. Kassab, S. Chekili, A. Laatar
Journal: Annals of the Rheumatic Diseases (2020)

Background: In the literature, non radiographic axial Spondyloarthritis (nr-SpA) is predominantly female with a shorter period of evolution and similar peripheral manifestations to radiographic axial spondyloarthritis (r-SpA). However, we do not have Tunisian studies comparing the two groups of axial spondyloarthritis (ax-SpA). Objectives: The aim of this study was to assess the epidemiological and clinical differences between nr-SpA and r-SpA in a group of Tunisian ax-SpA. Methods: Two hundred patients with ax-SpA (ASAS 2009 criteria) were retrospectively included and classified as r-Spa characterized by the presence of radiographic sacroiliitis and nr-SpA defined by the presence sacroiliitis only on MRI or HLA B27 antigen with other clinical features. The different demographic and clinical parameters were compared between the nr-SpA and r-SpA groups. Results: One hundred thirty-eight men and 62 women were included with a sex ratio of 2,2. The mean age was 43,3 ± 11,2 years and the mean period of evolution was 10,7 ± 8,4 years. The patients were divided to r-SpA in 80% of cases (n = 160) and nr-SpA in 20% of cases (n = 40). Women were more present in the nr-SpA group with 47,5% of women versus 26.8% of women in the r-SpA group (p = 0,01). The patients with nr-SpA were younger with a mean age of 39,4 ± 13,4 years versus 44,3 ± 10,4 years in patients with r-SpA (p = 0,03). The mean period of evolution was shorter in nr-SpA group (5,8 ± 4,9 years vs 11.9 ± 8.5; p &lt;0.001). The family history of SpA was more frequent in nr-SpA group (17.5% vs 4.3%, p = 0.004). Arthritis were more frequent in nr-SpA (42.5% vs 13.7%; p &lt;0.0001). Similarly, enthesitis were more frequent in nr-SpA group (45% vs 15.6%; p &lt;0.0001). No statistically significant differences were found in the following parameters: age at onset of symptoms, diagnostic delay, HLA B-27 antigen and dactylitis. Conclusion: The clinical features were different in the 2 groups of ax-SpA: Patients with nr-SpA were more female and had more peripheral manifestations while patients with r-SpA were older and with longer period of evolution. References: [1]de Winter JJ, et al. Arthritis Res Ther 2016; 18:196 [2]Malaviya AN, et al. Int J Rheum Dis 2015; 18(7):736–41 Disclosure of Interests: None declared