tbuckley/cabot-search huggingface dataset:
A Retrospective Study of Hospice Enrollment in Patients with Diffuse Large B Cell Lymphoma within the Veterans Health Administration
Authors: Kana Tai Lucero, Madison H. Williams, Ryan A. Williams, Snegha Ananth, Jean Pierre Blaize, Michael M. Song, Brian Warnecke, Abhishek Pandya, Lakene Raissa Djoufack Djoumessi, Phillip Nazarewicz, Manuel Ricardo Espinoza-Gutarra, Juan J. Toro, Lindsey Lu, Jennifer Whitehead, Kathleen Franklin, Michael Mader, Zohra Nooruddin
Journal: Blood (2021)
An Outpatient Management for First Cycle of Venetoclax and Hypomethylating Agents Results in Reduced Infection Rate and Hospitalizations in Acute Myeloid Leukemia Patients
Authors: Jacopo Nanni, Cristina Papayannidis, Gianluca Cristiano, Giovanni Marconi, Chiara Sartor, Sarah Parisi, Rashed Saed, Letizia Zannoni, Emanuela Ottaviani, Lorenza Bandini, Nicoletta Testoni, Carmen Baldazzi, Paolo Ricci, Chiara Di Giovanni Bezzi, Rania Abd-alatif, Stefania Paolini, Michele Cavo, Antonio Curti
Journal: Blood (2021)
Volumetric measurements are preferred in the evaluation of mutant IDH inhibition in non-enhancing diffuse gliomas: Evidence from a phase I trial of ivosidenib
Authors: Benjamin M Ellingson, Grace Hyun J Kim, Matt Brown, Jihey Lee, Noriko Salamon, Lori Steelman, Islam Hassan, Shuchi S Pandya, Saewon Chun, Michael Linetsky, Bryan Yoo, Patrick Y Wen, Ingo K Mellinghoff, Jonathan Goldin, Timothy F Cloughesy
Journal: Neuro-Oncology (2021)

Since IDH-mutant (mIDH) low-grade gliomas (LGGs) progress slowly and have a relatively long survival, there is a significant need for earlier measurements of clinical benefit. Guidance using the LGG RANO criteria recommends serial bidirectional (2D) measurements on a single slice; however, questions remain as to whether volumetric (3D) measurements are better, since they would allow for more accurate measurements in irregular shaped lesions and allow readers to better assess areas of subtle change.
Fc-Modified Kko: A Novel Therapeutic for Heparin-Induced Thrombocytopenia (HIT), Reversing Both the Thrombocytopenia and Thrombosis
Authors: Amrita Sarkar, Sanjay Khandelwal, Serge Yarovoi, Gowthami M. Arepally, Douglas B. Cines, Mortimer Poncz, Lubica Rauova
Journal: Blood (2021)
Timing and Immune Status after Cellular Therapies Predict Response to COVID-19 Vaccines
Authors: Roni Tamari, Ioannis Politikos, David Knorr, Santosha Vardhana, Jennifer Young, Leeann Marcello, Sital Doddi, Sean M Devlin, Lakshmi Ramanathan, Melissa S. Pessin, Erica Dunn, Meighan A. Palazzo, Christina Bravo, Genovefa A. Papanicolaou, Mini Kamboj, Miguel-Angel Perales, David J. Chung, Gunjan L Shah
Journal: Blood (2021)
Incidence of Invasive Fungal Infections (IFI) in Pediatric Acute Lymphoblastic Leukemia (ALL) and the Impact of Antifungal Prophylaxis in an Endemic Area
Authors: Simone M Chang, Mason Holt, Lauren Hernandez, Natalie Slone, Jun Zhao, Esther Elise Knapp, Kerry McGowan, Michael Huang, William T Tse, Alexandra Cheerva, Ashok Raj, Kyle Harwood, Joshua Elder, Mustafa Barbour
Journal: Blood (2021)
Clinical Efficacy Analysis of the Low-Dose Decitabine in Combination with Cytarabine, All-Trans Retinoic Acid and Granulocyte Colony-Stimulating Factor for Patients with MDS-EB
Authors: Ligen Liu, Yuanmmei Zhai, Li Yang, Limin Zhao, Li Chang, Chunrong Yin, Yingting Lu, Xuewei Jiang, Zhizhi Zhang
Journal: Blood (2021)
Dysregulated Neutrophil Iron Homeostasis in β-Thalassemia Impairs Phagocytosis and Reactive Oxygen Species Production
Authors: Sreenithi Santhakumar, Devi V.J, Leo stephen.R, Aruna Barade, Uday Prakash Kulkarni, Biju George, Eunice Sindhuvi
Journal: Blood (2021)
Heart Cardiac Sounds analysis using the Wigner distribution (WD) Method
Authors: S.M. DEBBAL
Journal: Clinical Cardiology and Cardiovascular Interventions (2021)

This paper is concerned a “The Wigner distribution (WD)” analysis of the Heart cardiac (or phonocardiogram signals: PCG). The Wigner distribution (WD) and the corresponding WVD (Wigner Ville Distribution) have shown good performances in the analysis of non-stationary and quantitative measurements of the time-frequency PCG signal characteristics. It is shown that these transforms provides enough features of the PCG signals that will help clinics to obtain diagnosis.
Coronary Angioplasty of the Circumflex Artery with anomalous Left Coronary Artery and origin from the Right Sinus of Valsalva ¨A Case Report¨
Authors: Rodrigo A. Martin, Ricardo Marcelo Cetera, Amalia Descalzo, Sergio Zolorza
Journal: Clinical Cardiology and Cardiovascular Interventions (2021)

We report a patient in the sixth decade of life with a benign anomalous course and a history of atherosclerotic disease in the right coronary artery with the presence of ischemia. We present a clinical case of infrequent finding of abnormal left coronary artery and obstructive atherosclerotic lesion in the circumflex artery. The authors decided to perform coronary angioplasty on the lesion found. Because it is an infrequent condition, we conducted a literature search in which we focused on the statistical findings, the clinical presentation and detailed the treatment of the patient by means of coronary angioplasty. Despite the difficulty of the case, success was achieved.
Emergency bowel surgery: audit shows some improvement, but concern remains
Authors: Jacqui Wise
Journal: BMJ (2021)

Mortality among patients in England and Wales undergoing emergency bowel surgery have been falling year on year, and hospital stays have become shorter, despite the effects of the covid-19 pandemic, the latest audit shows.1

However, the seventh national emergency laparotomy audit report also identified several concerns. Only a fifth of patients who had signs of sepsis on admission to hospital received antibiotics within the recommended one hour, a figure that has not improved since the data for England and Wales were first recorded in 2015. And almost a third of patients (31.6%) needing the …
A Randomized Phase III Study of Venetoclax-Based Time-Limited Combination Treatments (RVe, GVe, GIVe) Vs Standard Chemoimmunotherapy (CIT: FCR/BR) in Frontline Chronic Lymphocytic Leukemia (CLL) of Fit Patients: First Co-Primary Endpoint Analysis of the International Intergroup GAIA (CLL13) Trial
Authors: Barbara Eichhorst, Carsten Niemann, Arnon P. Kater, Moritz Fürstenau, Julia Von Tresckow, Can Zhang, Sandra Robrecht, Michael Gregor, Gunnar Juliusson, Patrick Thornton, Philipp B. Staber, Tamar Tadmor, Vesa Lindström, Caspar Da Cunha-Bang, Christof Schneider, Christian Bjørn Poulsen, Thomas Illmer, Björn Schöttker, Ann Janssens, Ilse Christiansen, Thomas Noesslinger, Michael Baumann, Marjolein van der Klift, Ulrich Jaeger, Henrik Frederiksen, Maria B.L. Leijs, Mels Hoogendoorn, Kourosh Lotfi, Holger Hebart, Tobias Gaska, Harry R. Koene, Florian Simon, Nisha De Silva, Anna-Maria Fink, Kirsten Fischer, Clemens-Martin Wendtner, Karl-Anton Kreuzer, Matthias Ritgen, Monika Brüggemann, Eugen Tausch, Mark-David Levin, Marinus H.J. Van Oers, Christian H. Geisler, Stephan Stilgenbauer, Michael Hallek
Journal: Blood (2021)
Outcomes of Chronic Lymphocytic Leukemia and Richter Transformation Following Discontinuation of Non-Covalent Bruton's Tyrosine Kinase Inhibitors
Authors: Meghan C. Thompson, Catherine C. Coombs, Lindsey E. Roeker, John M. Pagel, Jeffrey L. Jensen, Kristen E. Battiato, Yehudit Fox, Kendall Meyer, Neil Bailey, Joanna M Rhodes, Paola Ghione, Bita Fakhri, Toby A. Eyre, Anthony R. Mato
Journal: Blood (2021)
JSP191 As a Single-Agent Conditioning Regimen Results in Successful Engraftment, Donor Myeloid Chimerism, and Production of Donor Derived Naïve Lymphocytes in Patients with Severe Combined Immunodeficiency (SCID)
Authors: Rajni Agarwal, Christopher C. Dvorak, Susan Prockop, Hye-Sook Kwon, Janel R Long-Boyle, Anne Le, Janice W Brown, Elisabeth Merkel, Kenny Truong, Brenda Velasco, Kavitha Arulprakasam, Nicole Harada, Kirstin A Dougall, Susan S Prohaska, Wendy W Pang, Kevin N. Heller, Irving L Weissman, Morton J Cowan, Aaron C. Logan, Richard J O'Reilly, Robertson Parkman, Ken I. Weinberg, Maria Grazia Roncarolo, Judith A Shizuru
Journal: Blood (2021)
Obstructive sleep apnea: A categorical cluster analysis and visualization
Authors: D. Ferreira-Santos, P. Pereira Rodrigues
Journal: Pulmonology (2021)

Obstructive sleep apnea (OSA) is a prevalent sleep condition which is very heterogeneous although not formally characterized as such, resulting in missed or delayed diagnosis. Cluster analysis has been used in different clinical domains, particularly within sleep disorders. We aim to understand OSA heterogeneity and provide a variety of cluster visualizations to communicate the information clearly and efficiently.We applied an extension of k-means to be used in categorical variables: k-modes, to identify OSA patients' groups, based on demographic, physical examination, clinical history, and comorbidities characterization variables (n = 40) obtained from a derivation and validation cohorts (211 and 53, respectively) from the northern region of Portugal. Missing values were imputed with k-nearest neighbours (k-NN) and a chi-square test was held for feature selection.Thirteen variables were inserted in phenotypes, resulting in the following three clusters: Cluster 1, middle-aged males reporting witnessed apneas and high alcohol consumption before sleep; Cluster 2, middle-aged women with increased neck circumference (NC), non-repairing sleep and morning headaches; and Cluster 3, obese elderly males with increased NC, witnessed apneas and alcohol consumption. Patients from the validation cohort assigned to different clusters showed similar proportions when compared with the derivation cohort, for mild (C1: 56 vs 75%, P = 0.230; C2: 61 vs 75%, P = 0.128; C3: 45 vs 48%, P = 0.831), moderate (C1: 24 vs 25%; C2: 20 vs 25%; C3: 25 vs 19%) and severe (C1: 20 vs 0%; C2: 18 vs 0%; C3: 29 vs 33%) levels. Therefore, the allocation supported the validation of the obtained clusters.Our findings suggest different OSA patients' groups, creating the need to rethink these patients' stereotypical baseline characteristics.
Re: Toni K. Choueiri, Piotr Tomczak, Se Hoon Park, et al. Adjuvant Pembrolizumab after Nephrectomy in Renal-Cell Carcinoma. N Engl J Med 2021;385:683–94
Authors: Umberto Capitanio, Alessandro Larcher, Francesco Montorsi
Journal: European Urology (2021)
A non-classical monocyte-derived macrophage subset provides a splenic replication niche for intracellular Salmonella
Authors: Dotan Hoffman, Yaara Tevet, Sébastien Trzebanski, Gili Rosenberg, Leia Vainman, Aryeh Solomon, Shelly Hen-Avivi, Noa Bossel Ben-Moshe, Roi Avraham
Journal: Immunity (2021)

Interactions between intracellular bacteria and mononuclear phagocytes give rise to diverse cellular phenotypes that may determine the outcome of infection. Recent advances in single-cell RNA sequencing (scRNA-seq) have identified multiple subsets within the mononuclear population, but implications to their function during infection are limited. Here, we surveyed the mononuclear niche of intracellular Salmonella Typhimurium (S.Tm) during early systemic infection in mice. We described eclipse-like growth kinetics in the spleen, with a first phase of bacterial control mediated by tissue-resident red-pulp macrophages. A second phase involved extensive bacterial replication within a macrophage population characterized by CD9 expression. We demonstrated that CD9+ macrophages induced pathways for detoxificating oxidized lipids, that may be utilized by intracellular S.Tm. We established that CD9+ macrophages originated from non-classical monocytes (NCM), and NCM-depleted mice were more resistant to S.Tm infection. Our study defines macrophage subset-specific host-pathogen interactions that determine early infection dynamics and infection outcome of the entire organism.
Risk Stratification for Relapsed/Refractory Classical Hodgkin Lymphoma Integrating Pretransplant Deauville Score and Residual Metabolic Tumor Volume
Authors: Ho-Young Yhim, Yael Eshet, Ur Metser, Katherine Lajkosz, Matthew Cooper, Anca Prica, Vishal Kukreti, Sita Bhella, Noemie Lang, Wei Xu, Danielle Rodin, David Hodgson, Richard Tsang, Michael Crump, John Kuruvilla, Robert Kridel
Journal: Blood (2021)
Abstract 10788: Temporal Trends in the Utilization of Aortic Valve Replacement for Symptomatic Severe Aortic Stenosis from 2000-2017: Insights from a Multi-Centered Study
Authors: Shawn X Li, Nilay K Patel, Laura Flannery, Alexandra Selberg, Ritvik R Kandanelly, Fritha J Morrison, Varsha K Tanguturi, Daniela R Crousillat, Ayman Shaqdan, Ignacio Inglessis, Pinak B Shah, Jonathan Passeri, Tsuyoshi Kaneko, Arminder Jassar, Nathaniel Langer, Alexander Turchin, Sammy Elmariah
Journal: Circulation (2021)

Introduction: Despite the rapid growth of aortic valve replacement (AVR) for aortic stenosis (AS), studies have suggested that symptomatic severe AS remains undertreated. Hypothesis: The growth in patients with an indication for AVR has outpaced the number of AVRs performed. Methods: We identified patients with severe AS (aortic valve area &lt;1cm 2 ) on transthoracic echocardiograms from 2000-2017 at two large academic medical centers. Natural language processing (NLP) models were developed and validated to identify symptoms consistent with severe AS, and patients were classified based on ACC/AHA clinical guideline indications for AVR. Patients were divided into groups based on mean aortic valve gradient (mAVG≥ 40 or &lt;40mmHg) and left ventricular ejection fraction (LVEF≥50% or &lt;50%). Utilization of AVR (transcatheter aortic valve implantation [TAVI] or surgical aortic valve replacement [SAVR]) in patients with a clinical indication was examined over time, and clinical predictors of AVR were identified via multivariate logistic regression. Results: A total of 10,795 AS patients were included in this analysis, of whom 6,150 (57%) had an indication or potential indication for AVR and 2,976 (48%) received AVR. The frequency of AVR varied by AS subtype (HG-NEF: 69%, HG-LEF: 53%, LG-NEF: 32%, LG-LEF: 38%, p&lt;0.001). The adoption of TAVI contributed to the growth in AVR volume over time, however there has been a parallel rise in the number of patients with an indication for AVR (Figure). In patients with a class I indication for AVR, younger age, coronary artery disease, smoking history, higher hematocrit, outpatient index TTE, and LVEF≥0.5 were independently associated with an increased likelihood of receiving an AVR. Conclusions: Over an 18-year study period, the proportion of patients with an indication for AVR who do not receive AVR has remained significant despite the rapid growth of AVR volumes.
Brentuximab Vedotin, Nivolumab, Doxorubicin, and Dacarbazine (AN+AD) for Advanced Stage Classic Hodgkin Lymphoma: Preliminary Safety Results from the Single-Arm Phase 2 Study (SGN35-027 Part B)
Authors: Hun Ju Lee, Ian W. Flinn, Jason Melear, Rod Ramchandren, Judah Friedman, John M. Burke, Yuliya Linhares, Matthew R. Peterson, Mihir Raval, Rangaswamy Chintapatla, Tatyana A. Feldman, Habte Yimer, Miguel Islas-Ohlmayer, Asad Dean, Vishal Rana, Mitul D. Gandhi, John Renshaw, Amanda L. Gillespie-Twardy, Linda Ho, Michelle A. Fanale, Wenchuan Guo, Christopher A. Yasenchak
Journal: Blood (2021)
Modakafusp Alfa (TAK-573), an Immunocytokine, Shows Clinical Activity in Patients with Relapsed/Refractory Multiple Myeloma; Updated Results from a First-in-Human Phase 1 Study
Authors: Dan T. Vogl, Jonathan L. Kaufman, Sarah A. Holstein, Shebli Atrash, Omar Nadeem, Murali Janakiram, Kaveri Suryanarayan, Yuyin Liu, Sabrina Collins, Xavier Parot, Maria Chaudhry
Journal: Blood (2021)
Abstract 11458: Temporal Changes in Mitral Regurgitation After Percutaneous Mitral Valve Repair with MitraClip for Functional Mitral Regurgitation in Patients with Atrial Fibrillation
Authors: Goki Uno, Taku Omori, Shunsuke Kagawa, Takahiro Shiota
Journal: Circulation (2021)

Background: Recently, percutaneous mitral valve (MV) repair has been increasingly performed for functional mitral regurgitation (FMR). However, few studies have examined the effectiveness of percutaneous MV repair for atrial FMR (AFMR). The aim of this study is to compare the effectiveness of MitraClip implantation between patients with AFMR and ventricular FMR (VFMR). Methods: We retrospectively reviewed 113 grade 3 to 4+ FMR patients with persistent atrial fibrillation or atrial flutter who underwent MitraClip implantation. We classified the patients into 2 groups; 43 patients with preserved left ventricular (LV) ejection fraction (LVEF) ≥ 50% and normal LV wall motion were defined as AFMR. 70 patients with LV dysfunction (LVEF &lt; 50 %) or LV wall motion abnormality were defined as VFMR. Transthoracic echocardiography (TTE) follow-up was performed at approximately 1-day, 1-month and 1-year after the procedure. Results: The percentage of grade 4+ mitral regurgitation (MR) was 53% in AFMR and 49% in VFMR at baseline (P=0.61). Acute procedural success rate was similar between AFMR and VFMR (95.3% vs. 97.1%, P=0.49). The median period of 1-month and 1-year follow-up TTE were 33 [interquartile range (IQR): 28-36] days and 356 (IQR: 248-399) days in AFMR, and 34 (IQR: 30-38) days and 366 (IQR: 336-415) days in VFMR, respectively. The percentage of grade 3 or 4+ MR at 1-day, 1-month, and 1-year after the procedure were 4.7% (2/43), 10% (3/30), and 5.6% (1/18) in AFMR, and 2.9% (2/70), 7.3% (4/55), and 2.9% (1/35) in VFMR (P=0.49, 0.48, and 0.57, respectively, AFMR vs. VFMR at the same follow-up point). The rates of redo MitraClip or MV surgery for recurrent MR within 1-month and between 1-month/1-year were 0% and 9.3% in AFMR, and 1.4% and 1.4% in VFMR. The percentage of New York Heart Association functional class III or IV at baseline, 1-month, and 1-year after the procedure were 90.7% (39/43), 23.3% (7/30), and 33.3% (6/18) in AFMR and 97.1% (68/70), 27.3% (15/55), and 22.9% (8/35) in VFMR (P=0.15, 0.69, and 0.41, respectively, AFMR vs. VFMR at the same follow-up point). Conclusions: In our series, MitraClip implantation had comparable therapeutic effect on both MR severity and heart failure symptoms between patients with AFMR and VFMR.
MAIT and Vδ2 Unconventional T Cells Predict Favorable Outcome after Allogeneic HCT and Are Supported By a Diverse Intestinal Microbiome
Authors: Hana Andrlova, Oriana Miltiadous, Anqi Dai, Rui Gardner, Sary El Daker, John B Slingerland, Paul A Giardina, Annelie Clurman, Antonio L.C. Gomes, Chi L. Nguyen, Marina D Burgos da Silva, Susan DeWolf, Gabriel K Armijo, Nicole Lee, Roberta Zappasodi, Emily Fontana, Doris M Ponce, Christina Cho, Sergio A Giralt, Sean M Devlin, Jonathan U Peled, Justin Cross, Miguel-Angel Perales, Dale I Godfrey, Marcel van den Brink, Kate A Markey
Journal: Blood (2021)
Combinatorial Cytokine Secretion Signature of Donor-Derived T Cells Infused with the Graft: A New Potential Biomarker of Acute Graft-Versus-Host Disease in Αβt-Cell/CD19 B-Cell Depleted Hematopoietic Stem Cell Transplant Recipients
Authors: Raul Montiel-Esparza, Giulia Barbarito, Samantha Peck, Magali Bazzano, Rachana Patil, David C. Shyr, Gopin Saini, Robertson Parkman, Y. Lucy Liu, Alice Bertaina
Journal: Blood (2021)
Intraoperative pathologically-calibrated diagnosis of lymph nodes involved by breast cancer cells based on electrical impedance spectroscopy; a prospective diagnostic human model study
Authors: Reihane Mahdavi, Narges Yousefpour, Fereshteh Abbasvandi, Hossein Ataee, Parisa Hoseinpour, Mohammad Esmaeil Akbari, Mohammad Parniani, Belal Delshad, Maryam Avatefi, Zeinab Nourinejad, Saeed Abdolhosseini, Sajad Mehrvarz, Farzane Hajighasemi, Mohammad Abdolahad
Journal: International Journal of Surgery (2021)
Humoral and T Cell Immune Responses to Sars-Cov-2 Vaccination in Hematopoietic Cell Transplant Recipients
Authors: Eleni Gavriilaki, Anastasia Papadopoulou, Tasoula Touloumenidou, Fani Stavridou, Evdoxia Koravou, Maria Giannaki, Apostolia Papalexandri, Georgios Karavalakis, Ioannis Batsis, Andreas Kourelis, Fani Chatzopoulou, Dimitrios Chatzidimitriou, Damianos Sotiropoulos, Evangelia Yannaki, Ioanna Sakellari, Achilles Anagnostopoulos
Journal: Blood (2021)
Implementation and Preliminary Effectiveness of mHealth Apps for Improving Sickle Cell Disease Care during COVID-19: A Mixed-Methods Evaluation
Authors: Sherif M. Badawy, Lisa DiMartino, Donald Brambilla, Ana Baumann, Ebony Burns, Theresa Demartino, Sara Jacobs, Hamda Khan, Lisa Klesges, Abdullah Kutlar, Chinonyelum Nwosu, Nirmish Shah, Jane S Hankins
Journal: Blood (2021)
Cell-subpopulation alteration and FGF7 activation regulate the function of tendon stem/progenitor cells in 3D microenvironment revealed by single-cell analysis
Authors: Hong Zhang, Yangwu Chen, Chunmei Fan, Richun Liu, Jiayun Huang, Yanjie Zhang, Chenqi Tang, Bo Zhou, Xiaoyi Chen, Wei Ju, Yanyan Zhao, Jie Han, Peishan Wu, Shichen Zhang, Weiliang Shen, Zi Yin, Xiao Chen, Hongwei Ouyang
Journal: Biomaterials (2021)
Immunosuppressive Therapy in Large Granular Lymphocyte Leukemia-Associated Pure Red Cell Aplasia: Cyclophosphamide Responded Better Than Cyclosporine
Authors: Xiaoqing Liu, Ruixin Li, Zhengyuan Liu, Jiongtao Zhou, Lang Cheng, Qiqiang Long, Guangsheng He, Jianyong Li
Journal: Blood (2021)
The Combination of Umbralisib Plus Ublituximab Is Active in Patients with Relapsed or Refractory Marginal Zone Lymphoma (MZL): Results from the Phase 2 Global Unity-NHL Trial
Authors: Julio C. Chavez, Neta Goldschmidt, Felipe Samaniego, Tomasz Wrobel, Federica Cavallo, Gustavo Fonseca, Sung-Soo Yoon, Lubos Drgona, Eliza Hawkes, Itai Levi, Hari P. Miskin, Peter Sportelli, Owen A. O'Connor, Nathan H. Fowler, Pier Luigi Zinzani
Journal: Blood (2021)
Abstract 12405: Treatment With Impella and Veno-Arterial Extracorporeal Membrane Oxygenation During Extracorporeal Cardiopulmonary Resuscitation Improves Survival - A Multicenter Cohort Study
Authors: Tharusan Thevathasan, Megan Kenny, Sebastian Boie, Thomas Wurster, Jana Last, Rene Kalinowsky, Ulf Landmesser, Felix Balzer, Carsten Skurk
Journal: Circulation (2021)

Introduction: Left ventricular (LV) unloading with Impella has been shown to improve survival in patients with cardiogenic shock treated with veno-arterial extracorporeal membrane oxygenation (VA-ECMO). This study aimed to investigate whether treatment with VA-ECMO and Impella (so called “ECMELLA”) during extracorporeal cardiopulmonary resuscitation (i.e., cardiac arrest due to myocardial infarction and no return of spontaneous circulation at device implantation) was associated with improved outcomes. Hypothesis: ECMELLA treatment is associated with improved survival (primary outcome) as well as prolonged hospital and ICU length of stay (secondary outcomes) compared to VA-ECMO treatment. Methods: Cox proportional-hazard and Poisson regression models were used to analyze the association between treatment groups (ECMELLA vs. VA-ECMO) and outcomes. Analyses were adjusted for age, sex, body mass index, type of ECG rhythm (shockable vs. non-shockable), location of cardiac arrest (out of hospital vs. in-hospital) as well as first lactate and pH levels after device implantation. Results: 93 adult patients from three tertiary care centers were included, out of whom 52 (56%) received ECMELLA and 41 (44%) received VA-ECMO treatment. ECMELLA treatment was associated with decreased in-hospital mortality (HR 0.41 [95% CI 0.22-0.79], P=0.007), prolonged hospital (IRR 1.70 [95% CI 1.46-1.98], P&lt;0.001) and ICU length of stay (IRR 1.67 [95% CI 1.42-1.96], P&lt;0.001). Kaplan-Meier analysis confirmed survival benefits in the ECMELLA group (P=0.004, Figure 1). With an exploratory intent, we showed that LV ejection fraction was severely impaired at ICU admission immediately after device implantation (19% ECMELLA vs. 21% ECMO) but improved strongly in ECMELLA group at ICU discharge (38% ECMELLA vs. 31% ECMO). Conclusion: LV unloading in patients treated with VA-ECMO was associated with lower mortality rates during extracorporeal cardiopulmonary resuscitation.
Phase I/II Study of MAK683 in Patients with Advanced Malignancies, Including Diffuse Large B-Cell Lymphoma
Authors: Vincent Ribrag, Jean-Marie Michot, Lara Igleias, Daniel Tan, Brigette Ma, Matteo Duca, Zev A. Wainberg, Yu Yun Fan, Naoka Suenaga, Yi Cheng, Clinton Lai, Tomoya Yokota
Journal: Blood (2021)