tbuckley/cabot-search huggingface dataset:
Instructions for Authors
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Retinal Strokes
Authors: Carol R. Kollarits
Journal: JAMA (1972)

Seventy patients with retinal strokes were seen from August 1969 to March 1972. Fifty-three of these patients had a clinical picture suggestive of retinal artery occlusion due to emboli from atheromatous disease of the carotid bifurcation. Carotid arteriograms were performed in 45 of these patients. Carotid bifurcation atheromata were demonstrated as the probable source of emboli in 43 of the 45 patients (96%). Review of a series of 100 consecutive carotid arteriograms performed in hospital patients 60 years of age or older demonstrated an overall incidence of similar carotid atheromatous disease in only 24%. The striking incidence of carotid lesions in patients with retinal stroke syndromes suggests that most retinal strokes are caused by embolization from carotid bifurcation atheromata.
Phase I-II study to evaluate safety and efficacy of niraparib plus cabozantinib in patients with advanced urothelial/kidney cancer (NICARAGUA trial): Preliminary data of phase I study.
Authors: Daniel E. Castellano, Ignacio Duran, Begona Mellado, Miguel Angel A. Climent Duran, Xavier Garcia del Muro, Nuria Sala González, Teresa Alonso Gordoa, Elena Sevillano, Montserrat Domenech, Jesus Paramio, Francisco X. Real, Nuria Malats, Juan Luis Sanz, Albert Font
Journal: Journal of Clinical Oncology (2022)

490 Background: Niraparib (N) is a (PARP)-1/-2 inhibitor and Cabozantinib (C) is a tyrosine kinase (TK) inhibitor that targets VEGF signalling via inhibition of multiple TK receptors including c-MET and TAM kinases (TYRO3, AXL, MER). The c-Met receptor TK is abnormally activated and could be decrease response to PARP inhibitors. Preclinical data reveals that treatment with c-Met inhibitors renders cells more sensitive to PARP inhibition. A phase (Ph) I-II study was designed to explore the safety and efficacy of the combination of N + C in genitourinary cancers. Methods: Multicenter, open-label Ph I-II study (NCT03425201). Confirmed histopathological diagnosis of either metastatic urothelial carcinoma (mUC) or advanced clear cell renal cell carcinoma previously treated with a maximum of two previous regimens. Adequate bone marrow, liver and renal functions were required. The Ph I portion aimed to identify the maximum tolerated dose (MTD) and recommended ph II dose (RP2D). Pt received N and C p.o. once daily in 28-day cycles: Dose level 1 (DL1) N/C 100/20 mg; DL2 200/20 mg; DL3 200/40 mg; DL4 200/60 mg. A further amendment developed DL1.1 100/40 mg. Pt were accrued to each dose level in cohorts of 6 pt until the MTD was achieved (defined as highest dose at which ≤1 out of 6 pt experience a DLT, evaluated during the first 2 cycles). Results: Nineteen evaluable pt for DLT were included, 14 of them had UC. There was no DLT at DL1. Two out of the first 6 evaluable pt in DL2 had DLT (G3 thrombopenia and anemia and G3 diarrhea respectively). Upon analysis of these pt it was agreed to include 3 additional new pt for evaluation. Two pt were included with one presenting a DLT (G3 hepatic toxicity). Enrolment then continued in a new DL 1.1 cohort and 1 of 6 pts had DLT (G3 mucositis), being then considered the RP2D. No toxic deaths were reported. Six pt (32%) received at least 10 cycles and 9 pt (47%) received at least 6 cycles. Three patients (16%) achieved partial response (all of them with mUC disease) and 14 (74%) stable disease. Conclusions: N plus C combination can be safely administered with a manageable toxicity profile and preliminary efficacy was reported in mUC heavily pretreated pts. The RP2D is N 100 mg plus C 40 mg qd. Ph II study is now recruiting mUC patients. Clinical trial information: NCT03425201. [Table: see text]
PSMA PET in Prostate Cancer—A Biomarker or a Surrogate End Point?
Authors: Gartrell C. Bowling, Jordan D. Dimitrakoff
Journal: JAMA Oncology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
THE HOSPITAL PATHOLOGIST.SUICIDES.
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Update: Influenza Activity—United States, 1999-2000 Season
Authors: L. Brammer, E. Murray, K. Teates, S. Harper, K. Fukuda, A. Klimov, N. Cox, L. Rotz, R. Seither, M. Iwane
Journal: JAMA (2000)

In collaboration with the World Health Organization (WHO), its collaborating laboratories, and state and local health departments, CDC conducts surveillance to monitor influenza activity and to detect antigenic changes in the circulating strains of influenza viruses. This report summarizes influenza activity from October 4 through November 7, 1998; during this period, overall influenza activity in the United States was low. However, outbreaks of influenza A occurred in New York during October-November.
CircOGDH Is a Penumbra Biomarker and Therapeutic Target in Acute Ischemic Stroke
Authors: Yanfang Liu, Yufeng Li, Jiankun Zang, Tianyuan Zhang, Yaojie Li, Zefeng Tan, Dan Ma, Tao Zhang, Shiyong Wang, Yusheng Zhang, Lian Huang, Yousheng Wu, Xuanlin Su, Zean Weng, Die Deng, Chi Kwan Tsang, Anding Xu, Dan Lu
Journal: Circulation Research (2022)

Background: Acute ischemic stroke (AIS) is a leading cause of disability and mortality worldwide. Prediction of penumbra existence after AIS is crucial for making decision on reperfusion therapy. Yet a fast, inexpensive, simple, and noninvasive predictive biomarker for the poststroke penumbra with clinical translational potential is still lacking. We aim to investigate whether the CircOGDH (circular RNA derived from oxoglutarate dehydrogenase) is a potential biomarker for penumbra in patients with AIS and its role in ischemic neuronal damage. Methods: CircOGDH was screened from penumbra of middle cerebral artery occlusion mice and was assessed in plasma of patients with AIS by quantitative polymerase chain reaction. Magnetic resonance imaging was used to examine the penumbra volumes. CircOGDH interacted with miR-5112 (microRNA-5112) in primary cortical neurons was detected by fluorescence in situ hybridization, RNA immunoprecipitation, and luciferase reporter assay. Adenovirus-mediated CircOGDH knockdown ameliorated neuronal apoptosis induced by COL4A4 (Gallus collagen, type IV, alpha IV) overexpression. Transmission electron microscope, nanoparticle tracking analysis, and Western blot were performed to confirm exosomes. Results: CircOGDH expression was dramatically and selectively upregulated in the penumbra tissue of middle cerebral artery occlusion mice and in the plasma of 45 patients with AIS showing a 54-fold enhancement versus noncerebrovascular disease controls. Partial regression analysis revealed that CircOGDH expression was positively correlated with the size of penumbra in patients with AIS. Sequestering of miR-5112 by CircOGDH enhanced COL4A4 expression to elevate neuron damage. Additionally, knockdown of CircOGDH significantly enhanced neuronal cell viability under ischemic conditions. Furthermore, the expression of CircOGDH in brain tissue was closely related to that in the serum of middle cerebral artery occlusion mice. Finally, we found that CircOGDH was highly expressed in plasma exosomes of patients with AIS compared with those in noncerebrovascular disease individuals. Conclusions: These results demonstrate that CircOGDH is a potential therapeutic target for regulating ischemic neuronal viability, and is enriched in neuron-derived exosomes in the peripheral blood, serving as a predictive biomarker of penumbra in patients with AIS.
Engineered Delivery of Dental Stem‐Cell‐Derived Extracellular Vesicles for Periodontal Tissue Regeneration
Authors: Jana Zarubova, Mohammad Mahdi Hasani‐Sadrabadi, Erfan Dashtimoghadam, Xuexiang Zhang, Sahar Ansari, Song Li, Alireza Moshaverinia
Journal: Advanced Healthcare Materials (2022)

Periodontal disease begins as an inflammatory response to a bacterial biofilm deposited around the teeth, which over time leads to the destruction of tooth-supporting structures and consequently tooth loss. Conventional treatment strategies show limited efficacy in promoting regeneration of damaged periodontal tissues. Here, a delivery platform is developed for small extracellular vesicles (sEVs) derived from gingival mesenchymal stem cells (GMSCs) to treat periodontitis. EVs can achieve comparable therapeutic effects to their cells of origin. However, the short half-lives of EVs after their administration along with their rapid diffusion away from the delivery site necessitate frequent administration to achieve therapeutic benefits. To address these issues, "dual delivery" microparticles are engineered enabling microenvironment-sensitive release of EVs by metalloproteinases at the affected site along with antibiotics to suppress bacterial biofilm growth. GMSC sEVs are able to decrease the secretion of pro-inflammatory cytokines by monocytes/macrophages and T cells, suppress T-cell activation, and induce the formation of T regulatory cells (Tregs) in vitro and in a rat model of periodontal disease. One-time administration of immunomodulatory GMSC sEV-decorated microparticles leads to a significant improvement in regeneration of the damaged periodontal tissue. This approach will have potential clinical applications in the regeneration of a variety of tissues.
Excess Weight Tied to Eight More Cancers
Journal: Cancer Discovery (2016)

According to an analysis of more than 1,000 epidemiologic studies, being overweight or obese increases the risk of eight cancers: stomach, liver, gallbladder, pancreas, ovary, and thyroid cancers, multiple myeloma, and meningioma. Researchers initially identified five other malignancies linked to excess body weight in 2002, including breast and endometrial cancers.
Gastric and duodenal ulceration after burns.
Journal: BMJ (1979)

variable improvement in mental function, but we do not know which patients (if any) will benefit from them or for how long treatment should continue.Whether a doctor prescribes them or not is therefore largely a matter of temperament.It cannot be overemphasised that drug treatment is only a minor part of the management of dementia.Indeed, by making the doctor feel that he is doing something, the administration of these drugs may actually deflect him from the really important tasks: providing the patient and family with sympathy, practical advice, and social support.13-15
AMA-RPS Actions Taken at Annual Meeting
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MEDICAL PROGRESS.
Journal: JAMA (1890)

<h3>The Effect of Freezing upon Impurities Contained in Water?</h3> —The Massachusetts State Board of Health, (June, 1890,) publish experiments with seventy-six samples of water, and 336 samples of ice from fifty-eight localities, to answer the above question. <i>In ice from polluted sources compared</i>with water from the same, the experiments showed: 1. That in the ice the color and salt had been removed. 2. That all but 13 per cent, of the other impurities of the water, as shown by chemical analysis, had been removed. 3, The number of bacteria in the cubic centimetre were: For<i>snow</i>(one sample) 1,246; for<i>clear</i>ice (part of the same cake as above,) 6; for clear ice from an unpolluted source, o. 4. The average of 12 samples from most polluted sources, 138. The number of bacteria varied much in different parts of the same cake. From the examinations which have been made,
Diabetic Gangrene
Authors: A. Grunberg, H. L. Davies, J. L. Blair
Journal: BMJ (1951)

of serum iron, the iron-binding capacity of the serum proteins, the serum copper, and the protoporphyrin were investigated in normochromic anaemia and in hypochromic anaemia.In true iron-deficiency states these show a characteristic pattern which is quite different from the nor- mal.This characteristic pattern was outlined in nine cases of microcytic hypochromic anaemia, and the regeneration towards normal was studied when these cases were given intravenous iron.
Gold nanoparticle-directed autophagy intervention for antitumor immunotherapy via inhibiting tumor-associated macrophage M2 polarization
Authors: Siyue Zhang, Fangyuan Xie, Kaichun Li, He Zhang, You Yin, Yuan Yu, Guangzhao Lu, Shihao Zhang, Yan Wei, Ke Xu, Yan Wu, Hong Jin, Lan Xiao, Leilei Bao, Can Xu, Yulin Li, Ying Lu, Jie Gao
Journal: Acta Pharmaceutica Sinica B (2022)

Tumor-associated macrophages (TAMs), one of the dominating constituents of tumor microenvironment, are important contributors to cancer progression and treatment resistance. Therefore, regulation of TAMs polarization from M2 phenotype towards M1 phenotype has emerged as a new strategy for tumor immunotherapy. Herein, we successfully initiated antitumor immunotherapy by inhibiting TAMs M2 polarization via autophagy intervention with polyethylene glycol-conjugated gold nanoparticles (PEG-AuNPs). PEG-AuNPs suppressed TAMs M2 polarization in both in vitro and in vivo models, elicited antitumor immunotherapy and inhibited subcutaneous tumor growth in mice. As demonstrated by the mRFP-GFP-LC3 assay and analyzing the autophagy-related proteins (LC3, beclin1 and P62), PEG-AuNPs induced autophagic flux inhibition in TAMs, which is attributed to the PEG-AuNPs induced lysosome alkalization and membrane permeabilization. Besides, TAMs were prone to polarize towards M2 phenotype following autophagy activation, whereas inhibition of autophagic flux could reduce the M2 polarization of TAMs. Our results revealed a mechanism underlying PEG-AuNPs induced antitumor immunotherapy, where PEG-AuNPs reduce TAMs M2 polarization via induction of lysosome dysfunction and autophagic flux inhibition. This study elucidated the biological effects of nanomaterials on TAMs polarization and provided insight into harnessing the intrinsic immunomodulation capacity of nanomaterials for effective cancer treatment.
Real-world experience with ustekinumab for the treatment of plaque psoriasis in pediatric patients: A retrospective, single-center chart review
Authors: Malika A. Ladha, Brian D. Rankin, Merna Adly, Rebeka Stevenson, Nadia J. Luca, Alim R. Devani, Vimal H. Prajapati
Journal: Journal of the American Academy of Dermatology (2022)
Motility
Authors: Ahmed Sultan, Nabih El-Ghawalby, Omar Fathy, Mohamed Wahab, Mohsen El-Barbary, Nabil Gad El-Hak, Gamal El-Ebiedy, Farouk Ezzat
Journal: Gut (1994)

3rd UEGW Oslo 1994 during f-u (P = 0.04); 8% in F2 present from entry and 0% in those developed during f-u (P = ns).The figures for late (>6 mths) VB were 67% for F3 from entry and 70% for F3 during FU (P = ns), 50% for F2 at entry and 34% for F2 during f-u (P = ns).Conclusions. (1)By univariate analysis VS seems to be the most important variable in predicting the first VB. (2)Different treatment strategies should be used for F2 and F3 varices. (3)Regular endoscopic f-u is needed to improve the prediction criteria for the first VB.
This Week in JAMA
Journal: JAMA (1999)

Aware of the transmission of bovine spongiform encephalopathy ("mad cow disease") to a few people who ate British beef in the past decade, blood banking officials consider the possibility of-and cost of preventing-the spread of transmissible spongiform encephalopathies through transfusion. SEE PAGE 1157The Medical Literature An approach to differential diagnosis in the clinical setting using studies of disease probability. SEE PAGE 1214 MSJAMARegulatory and legislative policies that are changing the US health care system are indirectly reshaping resident physician training.
Reflections and Operations. By Sir John O'Conor, K.B.E., M.A., M.D.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Eosinophilic colitis.
Authors: S Sullivan, M Troster
Journal: Gut (1987)

Eosinophilic colitis SIR, When we read the report by Moore et al on eosinophilic gastroenteritis with isolated colonic involvement (Gut 1986; 27: 1219-22) we were re- minded of a similar patient we have been following for five years.In November 1981 a 12 year old girl was seen with an eight week history of crampy lower abdominal pain, diarrhoea, and intermittent rectal bleeding.She averaged four bowel movements per day and occasionally a bowel movement at night.The stool was watery, brown in colour, and malodorous.The bleeding occurred with bowel movements, was bright red in colour and was mixed in with the stool.It varied in quantity.She denied fever, chills, anorexia, nausea or vomiting.Past health was unremarkable and functional inquiry was normal.Physical examina- tion, upper gastrointestinal series and follow through, and barium enema were normal.Colonoscopy to the mid-transverse colon revealed numerous haemorrhagic blebs 1-2 mm in diameter.Some were intact and looked like 'blood blisters', while others had ruptured.The intervening mucosa was endoscopically normal and the rectum was spared.Multiple biopsies were obtained and reported as showing moderately severe inflammation with a high proportion of inflam- matory cells being eosinophils.The inflammation did not extend past the muscularis mucosa.Crypt abscesses were not present, but sporadic cryptitis was seen.An unusual feature was that there was separa- tion of the superficial mucosal epithelium from the underlying lamina propria.Stools were negative for ova and parasites and no enteric pathogens were identified.Scotch tape test for pinworm was negative.Mild iron deficiency anaemia was present.The white blood cell count was normal without eosinophilia.Serum immunoglobulins including IgE were normal.Skin tests using the prick technique against milk, eggs, and wheat were negative.Complement studies were normal.A