tbuckley/cabot-search huggingface dataset:
Hsa_circ_0003258 promotes prostate cancer metastasis by complexing with IGF2BP3 and sponging miR-653-5p
Authors: Yu-Zhong Yu, Dao-Jun Lv, Chong Wang, Xian-Lu Song, Tao Xie, Tao Wang, Zhi-Min Li, Jia-Ding Guo, Du-Jiang Fu, Kang-Jin Li, Ding-Lan Wu, Franky Leung Chan, Ning-Han Feng, Zhe-Sheng Chen, Shan-Chao Zhao
Journal: Molecular Cancer (2022)

Abstract Background More and more studies have shown that circular RNAs (circRNAs) play a critical regulatory role in many cancers. However, the potential molecular mechanism of circRNAs in prostate cancer (PCa) remains largely unknown. Methods Differentially expressed circRNAs were identified by RNA sequencing. The expression of hsa_circ_0003258 was evaluated using quantitative real-time PCR and RNA in situ hybridization. The impacts of hsa_circ_0003258 on the metastasis of PCa cells were investigated by a series of in vitro and in vivo assays. Lastly, the underlying mechanism of hsa_circ_0003258 was revealed by Western blot, biotin-labeled RNA pulldown, RNA immunoprecipitation, luciferase assays and rescue experiments. Results Increased expression of hsa_circ_0003258 was found in PCa tissues and was associated with advanced TNM stage and ISUP grade. Overexpression of hsa_circ_0003258 promoted PCa cell migration by inducing epithelial mesenchymal transformation (EMT) in vitro as well as tumor metastasis in vivo , while knockdown of hsa_circ_0003258 exerts the opposite effect. Mechanistically, hsa_circ_0003258 could elevate the expression of Rho GTPase activating protein 5 (ARHGAP5) via sponging miR-653-5p. In addition, hsa_circ_0003258 physically binds to insulin like growth factor 2 mRNA binding protein 3 (IGF2BP3) in the cytoplasm and enhanced HDAC4 mRNA stability, in which it activates ERK signalling pathway, then triggers EMT programming and finally accelerates the metastasis of PCa. Conclusions Upregulation of hsa_circ_0003258 drives tumor progression through both hsa_circ_0003258/miR-653-5p/ARHGAP5 axis and hsa_circ_0003258/IGF2BP3 /HDAC4 axis. Hsa_circ_0003258 may act as a promising biomarker for metastasis of PCa and an attractive target for PCa intervention.
Mechanically evoked defensive attack is controlled by GABAergic neurons in the anterior hypothalamic nucleus
Authors: Zhiyong Xie, Huating Gu, Meizhu Huang, Xinyu Cheng, Congping Shang, Ting Tao, Dapeng Li, Yuan Xie, Jidong Zhao, Wei Lu, Zhibin Zhang, Cheng Zhan, Zongxiang Tang, Fan Zhang, Peng Cao
Journal: Nature Neuroscience (2022)
Leadership needed to revamp US quarantine plan
Authors: None The Lancet
Journal: The Lancet (2005)

In the wake of hurricane Katrina, it comes as little surprise that yet another potential disaster the USA is not prepared for is emerging diseases. An Institute of Medicine (IOM) report issued on Sept 1 (Quarantine Stations at Ports of Entry Protecting the Public's Health) says that much more attention needs to be given to the management of quarantine for ill people coming into the USA.
Race, Ethnicity, and Sex Among Senior Faculty in Radiation Oncology From 2000 to 2019
Authors: James R. Janopaul-Naylor, Sanford E. Roberts, Hui-Kuo Shu, Aparna H. Kesarwala, Jolinta Y. Lin, Jeffrey M. Switchenko, Mylin A. Torres
Journal: JAMA Network Open (2022)
Dabrafenib plus trametinib in patients with BRAF V600E-mutant anaplastic thyroid cancer: updated analysis from the phase II ROAR basket study
Authors: V. Subbiah, R.J. Kreitman, Z.A. Wainberg, J.Y. Cho, J.H.M. Schellens, J.C. Soria, P.Y. Wen, C.C. Zielinski, M.E. Cabanillas, A. Boran, P. Ilankumaran, P. Burgess, T. Romero Salas, B. Keam
Journal: Annals of Oncology (2022)

Combined therapy with dabrafenib plus trametinib was approved in several countries for treatment of BRAF V600E-mutant anaplastic thyroid cancer (ATC) based on an earlier interim analysis of 23 response-assessable patients in the ATC cohort of the phase II Rare Oncology Agnostic Research (ROAR) basket study. We report an updated analysis describing the efficacy and safety of dabrafenib plus trametinib in the full ROAR ATC cohort of 36 patients with ∼4 years of additional study follow-up.ROAR (NCT02034110) is an open-label, nonrandomized, phase II basket study evaluating dabrafenib plus trametinib in BRAF V600E-mutant rare cancers. The ATC cohort comprised 36 patients with unresectable or metastatic ATC who received dabrafenib 150 mg twice daily plus trametinib 2 mg once daily orally until disease progression, unacceptable toxicity, or death. The primary endpoint was investigator-assessed overall response rate (ORR) per Response Evaluation Criteria in Solid Tumors version 1.1. Secondary endpoints were duration of response (DOR), progression-free survival (PFS), overall survival (OS), and safety.At data cutoff (14 September 2020), median follow-up was 11.1 months (range, 0.9-76.6 months). The investigator-assessed ORR was 56% (95% confidence interval, 38.1% to 72.1%), including three complete responses; the 12-month DOR rate was 50%. Median PFS and OS were 6.7 and 14.5 months, respectively. The respective 12-month PFS and OS rates were 43.2% and 51.7%, and the 24-month OS rate was 31.5%. No new safety signals were identified with additional follow-up, and adverse events were consistent with the established tolerability of dabrafenib plus trametinib.These updated results confirm the substantial clinical benefit and manageable toxicity of dabrafenib plus trametinib in BRAF V600E-mutant ATC. Dabrafenib plus trametinib notably improved long-term survival and represents a meaningful treatment option for this rare, aggressive cancer.
Tachycardias: Mechanisms, Diagnosis, Treatment.
Journal: Annals of Internal Medicine (1985)

received more than passing mention had the sym- posium been held just a little later.It is no criticism to label some of the contents as being ephemeral, for that is the price of progress.Those not actively involved in such research have an opportunity to see the evolution in treatment patterns, while sharing with many of the commentators uncer- tainty about the potential long-term, benefits and how they are to be assessed.
Summaries of Key Journal Articles
Authors: Kim A. Eagle, Christopher P. Cannon, William F. Armstrong, David S. Bach, Ragavendra R. Baliga, Anna M. Booher, Timothy B. Cotts, Daniel T. Eitzman, James B. Froehlich, Caren S. Goldberg, Hitinder S. Gurm, Jennifer C. Hirsch, Elizabeth Anne Jackson, Fred Morady, Debabrata Mukherjee, Himanshu J. Patel, John E. Rectenwald, Melvyn Rubenfire
Journal: Journal of the American College of Cardiology (2010)
Abstract P324: Association of Neighborhood Perception and Physical Activity in the Healthy Aging in Neighborhoods of Diversity Across the Lifespan (HANDLS) Study
Authors: Sophie E Claudel, Eric J Shiroma, Tamara B Harris, Chaarushi Ahuja, Alan B Zonderman, Michele K Evans, Tiffany M Powell-Wiley
Journal: Circulation (2018)

Introduction: As obesity rates rise, it is increasingly important to understand obesity-related health behaviors, including physical activity (PA). Less is known about the role of perceived neighborhood environment, particularly perceptions of crime and violence, in preventing PA. Hypothesis: Unfavorable neighborhood perception is associated with lower PA levels, and may be moderated by socioeconomic status (SES). Methods: Within the multiracial, socioeconomically diverse HANDLS cohort, we examined the association between self-reported neighborhood perception (Likert-scale questions) and physical activity (Baecke PA questionnaire). Factor analysis identified key neighborhood characteristics to develop a total neighborhood perception score (NPS), which was divided into quintiles for analysis. Higher NPS indicated less favorable neighborhood perception. Linear regression was used to determine the relationship between total NPS, factor scores, and PA. Results: In Wave 4 [n=2167; mean age 56.6(9.1) years, 58.6% female, 61.1% black, 40.5% below poverty line], we identified five neighborhood perception factors: 1) concern about specific crime types 2) physical environment, 3) violent crime, 4) social environment and 5) violence beyond the neighborhood. Across NPS quintiles, those in quintile 5 were more likely to be younger ( p &lt; 0.001), white ( p &lt; 0.001), above the poverty level ( p &lt; 0.001), and more highly educated ( p &lt; 0.001), but less likely to be smokers ( p = 0.05) or engage in leisure time PA ( p &lt; 0.001). Total PA decreased with increasing NPS in Factor 4 across all race/sex groups and with total NPS for white females. Total PA increased with increasing NPS in Factor 3 for white males. The NPS-PA relationship was not moderated by SES. Conclusions: Poor perceived social cohesion is associated with decreasing PA, while - paradoxically - increased perceived violent crime is associated with higher PA for white males. Further work should investigate potential mediators between social cohesion, crime and PA.
Real-world outcomes in patients with neuroendocrine tumor receiving peptide receptor radionucleotide therapy.
Authors: Stijn Hentzen, Kathan Mehta, Raed Moh'd Taiseer Al-Rajabi, Anwaar Saeed, Joaquina Celebre Baranda, Stephen K. Williamson, Weijing Sun, Anup Kasi
Journal: Journal of Clinical Oncology (2022)

504 Background: (177)Lu-Dotatate, a form of Peptide Receptor Radionuclide Therapy (PRRT), was approved by FDA for treatment of somatostatin-receptor-positive NETs in 2018. Clinical trials prior to the FDA approval of (177)Lu-Dotatate showed favorable outcomes but there is limited published real world outcomes data. Methods: After obtaining IRB approval we retrospectively evaluated the efficacy of (177)Lu-Dotatate PRRT for somatostatin receptor positive gastroenteropancreatic NET patients at University of Kansas Cancer Center between June 2018 and September 2021. Results: A total of 65 patients received PRRT of which 58 completed treatment and 7 are still undergoing therapy. The 58 patients who completed treatment had a median age of 61.5 years, included 24 females and 34 males, and were 86% Caucasian and 12% black. These patients had primarily NETs of small bowel (n=24) and pancreatic (n=14) origin. Pathology showed grades 1 (21), 2 (25), and 3 (4) with a majority of well-differentiated tumors (47). All 4 treatments of PRRT were completed by 43 patients. In the entire cohort, response assessment to PRRT revealed 14 (26.9%) partial response (PR), 31 (59.6%) with stable disease (SD) and 7 (13.5%) with progressive disease (PD). In subset analysis, we found that patients with nonfunctional disease (n=29) had a higher rate of PR 42.3% vs 11.5% (p=0.0147) and higher disease control rate 96% vs 78% (p=0.042) than functional disease (n=29). Patients with nonfunctional disease had a lower PD 3.85% vs 23% (p=0.0147) and 53% vs 65% stable disease than functional disease. The table below shows clinical characteristics of these patients. Conclusions: Our real world outcomes analysis of NET treated with PRRT shows improved PR when compared to the initial clinical trials which is promising for patients. In addition, we found that there was statistically significant improved response rate in patients with non functional tumors which has not been described in literature before. If our study findings are validated in a larger cohort then it may guide patient selection for PRRT therapy in the future.[Table: see text]
COVID-19 and Cancer Center Operations: Lessons Learned From the NCCN Best Practices Committee
Authors: Jessica M. Sugalski, Theresa Franco, Lawrence N. Shulman, Elizabeth Souza, Ephraim Hochberg, Anne Chiang, Scott Lawrence, Diana Krause, Timothy Kubal
Journal: Journal of the National Comprehensive Cancer Network (2022)

The NCCN Best Practices Committee, which is composed of senior physician, nursing, and administrative leaders from NCCN Member Institutions, evaluated the status of cancer center operations after 1 year of operating during the COVID-19 pandemic. Two major initiatives stood out: the increase in the utilization of network sites, and the gains made in telemedicine operations and reimbursement. Experts from NCCN Member Institutions participated in a webinar series in June 2021 to share their experiences, knowledge, and thoughts on these topics and discuss the impact on the future of cancer care.
Rational design of biodegradable thermoplastic polyurethanes for tissue repair
Authors: Cancan Xu, Yi Hong
Journal: Bioactive Materials (2021)

As a type of elastomeric polymers, non-degradable polyurethanes (PUs) have a long history of being used in clinics, whereas biodegradable PUs have been developed in recent decades, primarily for tissue repair and regeneration. Biodegradable thermoplastic (linear) PUs are soft and elastic polymeric biomaterials with high mechanical strength, which mimics the mechanical properties of soft and elastic tissues. Therefore, biodegradable thermoplastic polyurethanes are promising scaffolding materials for soft and elastic tissue repair and regeneration. Generally, PUs are synthesized by linking three types of changeable blocks: diisocyanates, diols, and chain extenders. Alternating the combination of these three blocks can finely tailor the physio-chemical properties and generate new functional PUs. These PUs have excellent processing flexibilities and can be fabricated into three-dimensional (3D) constructs using conventional and/or advanced technologies, which is a great advantage compared with cross-linked thermoset elastomers. Additionally, they can be combined with biomolecules to incorporate desired bioactivities to broaden their biomedical applications. In this review, we comprehensively summarized the synthesis, structures, and properties of biodegradable thermoplastic PUs, and introduced their multiple applications in tissue repair and regeneration. A whole picture of their design and applications along with discussions and perspectives of future directions would provide theoretical and technical supports to inspire new PU development and novel applications.
Coronary endothelial function in patients with coronary spastic angina: role of transcardiac formation of oxidized LDL Kazuo Minai, Tetsuya Matsumoto, Hajime Horie, Hiroshi Yokohama, Hiroyuki Takashima, Naoto Ohira, Tsutsui Takashi, Takayoshi Tsutamoto, Masayuki Takahashi, Masahiko Kinoshita. First Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
Journal: Journal of the American College of Cardiology (2001)
Characteristics and blood pressure responses of 6,057 hispanic hypertensive patients with coronary artery disease enrolled in the INVEST Rhonda M. Cooper-DeHolf, Eileen M. Handberg, Heather A. Bristol, Henry R. Kolb, Efrain Gaxiola, Jose Cangiano, Carl J. Pepine, for the INVEST Investigators. University of Florida, Gainesville, FL
Journal: Journal of the American College of Cardiology (2001)
DERMATOLOGY
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
&lt;TITLE&gt;High Blood Pressure During Pregnancy&lt;/TITLE&gt;
Authors: Brian Pace, Cassio Lynm, Richard Glass
Journal: JAMA (2001)

is a public service of JAMA.The information and recommendations appearing on this page are appropriate in most instances, but they are not a substitute for medical diagnosis.For specific information concerning your personal medical condition, JAMA and the AMA suggest that you consult your physician.This page may be reproduced noncommercially by physicians and other health care professionals to share with patients.Any other reproduction is subject to AMA approval.
Poppet embolization from Braunwald-Cutter aortic valve
Authors: R. Pifarre
Journal: JAMA (1977)

RECENTLY, McGoon pointed out the limitations of the prostheses available for aortic valve replacement.<sup>1</sup>Although the majority of prosthetic valves available are durable and hemodynamically acceptable, the threat of thromboembolism has continued to exist. Disk variance has been reported to occur in various models of disk prostheses. Recently, our service reported four cases of disk thinning, grooving, and notching in Beall mitral valve prostheses.<sup>2</sup>Those changes resulted in migration of the disk in one case. It was pointed out that the awareness of the various manifestations of disk variance is essential for the care of patients after prosthetic valve replacement. Although ball-valve variance in the original Starr-Edwards aortic valve was well recognized, Silastic ball embolization has been reported rarely. In 1971, the Braunwald-Cutter clothcovered prosthesis with a Silastic poppet became available for clinical use.<sup>3</sup>In 1974, Pluth and Danielson<sup>4</sup>reported two cases of poppet escape that
Optimal dosing of a glycoprotein IIb/IIIa antagonist with a simplified renal-based algorithm: Pharmacodynamic and clinical findings from PARAGON B Christopher K. Dyke, Kenneth W. Mahaffey, Lisa G. Berdan, Magnus Ohman, Kristin Newby, Rodney A. Sparapani, Peter B. Berger, Neal S. Kleiman, Harvey D. White, Judith S. Hochman, Frans van de Werf, Paul W. Armstrong, Robert M. Califf, Robert A. Harrington, Eric J. Topol. Duke Clinical Research Institute, Durham, NC
Journal: Journal of the American College of Cardiology (2001)
Has the COVID-19 pandemic wiped out the seasonality of outpatient antibiotic use and influenza activity? A time-series analysis from 2014 to 2021
Authors: Ana Belén Guisado-Gil, Regina Sandra Benavente, Román Villegas-Portero, María Victoria Gil-Navarro, Raquel Valencia, Germán Peñalva, José Miguel Cisneros
Journal: Clinical Microbiology and Infection (2022)
Complexities of eGFRs in a Study of Glomerular Physiology
Authors: Robert W. Steiner
Journal: Journal of the American Society of Nephrology (2020)

In a recent article in JASN , Collard et al. [1][1] used a new method to indirectly determine glomerular pressures (Pglom) from renal artery pressures and flows that were measured in 28 patients undergoing angiography. Kidney function was expressed as a patient's eGFR by the Chronic Kidney Disease
Evaluation of Factors Underlying Sex-Based Disparities in Cardiovascular Care in Adults With Self-reported Premature Atherosclerotic Cardiovascular Disease
Authors: Vardhmaan Jain, Mahmoud Al Rifai, Rodman Turpin, Hatice Nur Eken, Ankit Agrawal, Dhruv Mahtta, Zainab Samad, Stephanie Coulter, Fatima Rodriguez, Laura A. Petersen, Salim S. Virani
Journal: JAMA Cardiology (2022)

<h3>Importance</h3> There are limited data regarding sex-based differences in physical and mental health domains and health care access in adults with premature atherosclerotic cardiovascular disease (ASCVD). <h3>Objective</h3> To study the association of sex with physical and mental health domains as well as health care access–related factors among adults with self-reported premature ASCVD. <h3>Design, Setting, and Participants</h3> Retrospective cohort analysis of 748 090 adults aged 18 to 55 years in the Behavioral Risk Factor Surveillance System 2016 to 2019 in the US. Data were analyzed from June to July 2021. <h3>Exposures</h3> Self-reported ASCVD, defined as having a history of coronary artery disease, myocardial infarction, or stroke. <h3>Main Outcomes and Measures</h3> Self-reported physical and mental health and measures of health care access, including self-reported cost-related medication nonadherence and inability to see a physician due to cost. <h3>Results</h3> Between 2016 and 2019, 748 090 adults aged 18-55 years were identified, of whom 28 522 (3.3%) had self-reported premature ASCVD. Of these, 14 358 (47.0%) were women. Compared with men, women with premature ASCVD were more likely to report being clinically depressed (odds ratio [OR], 1.73; 95% CI, 1.41-2.14;<i>P</i> &lt; .001), have cost-related medication nonadherence (OR, 1.42; 95% CI, 1.11-1.82;<i>P</i> = .005), have not seen a physician due to cost-related issues (OR, 4.52; 95% CI, 2.24-9.13;<i>P</i> &lt; .001), and were more likely to report overall poor physical health (OR, 1.39; 95% CI, 1.09-1.78;<i>P</i> = .008) despite being more likely to have health care coverage (85.3% vs 80.8%;<i>P</i> = .04) and a primary care physician (84.2% vs 75.7%;<i>P</i> &lt; .001). <h3>Conclusions and Relevance</h3> Results from this study indicate that women with premature ASCVD were more likely to report worse overall physical and mental health, inability to see a physician due to cost, and cost-related medical nonadherence. Interventions addressing mental health and out-of-pocket costs are needed in adults with premature ASCVD.
Abstract 17406: Early Experience With Ultrasound Guided Distal Trans-Radial Access in the Anatomical Snuffbox in Coronary Angiography and Intervention
Authors: Sangyeub Lee, Woong-su Yoon, Daehwan Bae, Min Kim, Sang Min Kim, Jang-Whan Bae, Kyung-Kuk Hwang, Myeong-Chan Cho
Journal: Circulation (2018)

Early experience with ultrasound guided distal trans-radial access in the anatomical snuffbox in coronary angiography and intervention. Objective: We aimed to demonstrate the feasibility and safety of the ultrasound guided distal trans-radial coronary angiography and intervention. Methods: Patients assigned to one operator program underwent diagnostic or procedural intervention through distal trans-radial approach in the anatomical snuffbox between January 2018 and May 2018. All of patients had palpable artery in their distal radial artery. The operator did the coronary procedure via distal radial access at anatomical snuffbox. When the pulse was weak or the target artery was very small, the operator punctured under ultrasound guidance (V-scan with dual probe, GE heathcare, USA) Results: 56 patients were enrolled. Mean age of patients was 65.1 years old and 68% were male. About 70% of patients were presented with stable angina feature. In diagnostic procedure, 4F (3, 5.6%) or 5F (29, 54.7%) sheath was used and we did coronary intervention via 6F (21, 39.6%) Sheath. Ultrasound guided puncture was done for 33 patients (58.9%). Overall Success rate of distal trans-radial angiography and intervention was 94.6% (3 failed cases). Success rate of ultrasound guided procedure was 97% (only 1 failed case). Left distal radial puncture was done for 18 patients (33.9%). 16% of patients had chronic kidney disease, especially end stage renal disease (11%) to preserve radial artery which was potential candidate of arteriovenous fistulae for dialysis. There was no BARC type 2-5 bleeding in hospital stay and follow up at out-patient clinic. Conclusion: Ultra sound guided distal radial approach is feasible and safe as a good alternative technique for coronary angiography and interventions.