tbuckley/cabot-search huggingface dataset:
ACCIDENT POLICIES AND PROFESSIONAL RISKS.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Daniel Drake and medical education
Authors: C. D. Aring
Journal: JAMA (1985)

For William Osler,<sup>1</sup>Daniel Drake was a unique figure in American medicine and the founder of nearly everything that is old and good in Cincinnati. Certainly he is one of the most fascinating individuals in medical history. Of particular interest is his abiding concern with education and the legacy of schools and hospitals he left behind him. In addition to founding the institutions that later became the University of Cincinnati and the Cincinnati General Hospital, he organized scientific and medical societies, a natural history museum, libraries, a botanical garden, academies, and schools of all sorts, including those for professional teachers and for the education of the blind and the deaf and dumb. Daniel Drake (1785-1852) was not only the leading pioneer physician west of the Alleghenies but also an indefatiguable man of letters, a naturalist, philosopher, teacher, and humanist. The first man in Cincinnati to receive an MD, he
Chronotropic incompetence vs. echocardiographic ischemia in prognosis of high risk patients with coronary artery disease Dejan Orlic, Moidrag Ostojic, Branko Beleslin, Goran Stankovic, Ana Djordjevic-Dikic, Ivana Nedeljkovic, Milan Nedeljkovic, Sinisa Stojkovic, Vladan Vukcevic, Jelena Stepanovic. Institute for CVD, Belgrade, Yugoslavia
Journal: Journal of the American College of Cardiology (2001)
The Physician’s Responsibility: An Important Decision on Professional Secrecy
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ON DISTICHIASIS
Authors: H. Walton
Journal: BMJ (1853)

we must take cae that we do not excite inhmmation of the ovaries, or of the womb.When we find the patient complaining of severe pain in the loins, and suffering from general fever, we ought at once to discontinue mammary irritation, and prescribe rest in bed, abdominal fomenta- tions, and the frequent use of the hip-bath.In cases of this description, as in ordinary attacks of dysmennorrhea, we may often not only relieve pain, but accelerate a resolution of the inflammation, by administering opiate enemata.Caution on the part of the practitioner will generally en- able him to prevent or speedily remove the evils and incon- veniences to which reference has been made.They may, however, so easily occur through the want of it, and lead to so much discredit and embarrassment, that I have been anxious to give them the prominence which they deserve.
SARS-CoV-2 Beta and Delta variants trigger Fc effector function with increased cross-reactivity
Authors: Simone I. Richardson, Nelia P. Manamela, Boitumelo M. Motsoeneng, Haajira Kaldine, Frances Ayres, Zanele Makhado, Mathilda Mennen, Sango Skelem, Noleen Williams, Nancy J. Sullivan, John Misasi, Glenda G. Gray, Linda-Gail Bekker, Veronica Ueckermann, Theresa M. Rossouw, Michael T. Boswell, Ntobeko A.B. Ntusi, Wendy A. Burgers, Penny L. Moore
Journal: Cell Reports Medicine (2022)
Congenital atresia of the colon
Authors: S. S. Lee
Journal: JAMA (1967)

In a newborn baby, congenital atresia of the right colon was treated successfully with resection of the proximal intestine and end-to-end ileotransverse colostomy. A disparity in the size of the right colon in comparison to that of the terminal part of the ileum was noted, and was probably due to competence of the ileocecal valve, which prevented backward flow from the right colon to the ileum. This factor, combined with colonic atresia, may lead to a gangrenous right colon with perforation of the intestine if early diagnosis is not established.
3D-printed NIR-responsive shape memory polyurethane/magnesium scaffolds with tight-contact for robust bone regeneration
Authors: Yuanchi Zhang, Cairong Li, Wei Zhang, Junjie Deng, Yangyi Nie, Xiangfu Du, Ling Qin, Yuxiao Lai
Journal: Bioactive Materials (2021)

Patients with bone defects suffer from a high rate of disability and deformity. Poor contact of grafts with defective bones and insufficient osteogenic activities lead to increased loose risks and unsatisfied repair efficacy. Although self-expanding scaffolds were developed to enhance bone integration, the limitations on the high transition temperature and the unsatisfied bioactivity hindered greatly their clinical application. Herein, we report a near-infrared-responsive and tight-contacting scaffold that comprises of shape memory polyurethane (SMPU) as the thermal-responsive matrix and magnesium (Mg) as the photothermal and bioactive component, which fabricated by the low temperature rapid prototyping (LT-RP) 3D printing technology. As designed, due to synergistic effects of the components and the fabrication approach, the composite scaffold possesses a homogeneously porous structure, significantly improved mechanical properties and stable photothermal effects. The programmed scaffold can be heated to recover under near infrared irradiation in 60s. With 4 wt% Mg, the scaffold has the balanced shape fixity ratio of 93.6% and shape recovery ratio of 95.4%. The compressed composite scaffold could lift a 100 g weight under NIR light, which was more than 1700 times of its own weight. The results of the push-out tests and the finite element analysis (FEA) confirmed the tight-contacting ability of the SMPU/4 wt%Mg scaffold, which had a signficant enhancement compared to the scaffold without shape memory effects. Furthermore, The osteopromotive function of the scaffold has been demonstrated through a series of
Medical News.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical usefulness of postoperative serum carcinoembryonic antigen in colorectal cancer patients with liver metastases.
Authors: Koichiro Yoshino, Hiroki Osumi, Eiji Shinozaki, Hiromichi Ito, Daisaku Kamiimabeppu, Akira Ooki, Takeru Wakatsuki, Keitaro Shimozaki, Izuma Nakayama, Mariko Ogura, Daisuke Takahari, Keisho Chin, Atsushi Oba, Yoshihiro Ono, Takafumi Sato, Yosuke Inoue, Yu Takahashi, Kensei Yamaguchi
Journal: Journal of Clinical Oncology (2022)

178 Background: Colorectal cancer with liver metastases (CLM) has high post operative recurrence rates, and optimizing the perioperative treatment is imperative. Post operative carcinoembryonic antigen (CEA) can help detecting minimal residual disease in colon cancer after curative resection. Methods: The aim of this study was to identify the potential role of serum CEA after liver resection in patients with CLM. This study was conducted at the Cancer Institute Hospital, Japanese Foundation for Cancer Research from 2004 to 2018. Patients with CLM who underwent complete resection of primary tumors and liver metastases were enrolled in this study. We studied the associations between the perioperative CEA levels and characteristics of recurrence. Results: Recurrence was detected during the median follow-up time of 50.9 months in 343 (54.1%) of the total 633 patients analyzed. Patients with postoperative CEA (&gt;5) group had a significantly higher recurrence rate (75.7% vs 50.0%, p &lt; 0.01), with a shorter time until recurrence (4.4 months vs 36.9 months, p &lt; 0.01) than those with a postoperative CEA level (≤5) group. In multivariate analysis, a postoperative CEA level &gt;5 ng/ ml was an independent predictor, with the highest hazard ratio for both recurrence free survival (RFS) and overall survival (OS) (RFS: 2.77, 95% confidence interval [CI] 2.14–3.60, p &lt;0.01, OS: 3.18, 95% CI 2.41–4.19, p &lt;0.01). In addition, there was a significantly shorter RFS in the postoperative CEA level (&gt;5) group who did not have normalized CEA levels after adjuvant chemotherapy compared to normalized CEA group (3.3 months vs 18.5 months, p = 0.008). Conclusions: The postoperative CEA and postadjuvant chemotherapy CEA level in the CEA level (&gt;5) group after surgery may be a predictor of RFS and OS.
Jogging
Authors: Waldo E. Harris
Journal: JAMA (1967)

Although it is accepted that regular moderate exercise is beneficial to health,<sup>1</sup>a large segment of the male population of the United States over the age of 30 leads a relatively sedentary life. In many professions and occupations, the amount of exercise obtained depends upon the opportunity to engage in leisure activities. These activities, such as golf, bowling, fishing, hunting, handball, volleyball, tennis, and physical-education classes, often have major drawbacks in respect to time involved, convenience, expense, reservation of facilities, possession of adequate skills, and regularity of participation. Some types of physical exertion have serious disadvantages for older age groups. Competitive sports and hunting may involve short periods of intensive effort undesirable for those in poor physical condition. Other activities provide a questionable amount of actual physical exertion. Exercise that is intermittent, such as golf, bowling, and fishing, may fail to provide the desirable degree of body stress found
Screen Often and With Trusted Community Members to Improve Autism Identification for Latine Children
Authors: Kate E. Wallis, Monica M. Abdul-Chani, Katharine E. Zuckerman
Journal: JAMA Pediatrics (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Differences between FEV6, FVC and VC at the diagnosis of obstructive ventilatory defect
Authors: C.S. Sousa, D.B. Coelho, P. Amorim, P. Viana, N. Cruz-Martins, M. Drummond
Journal: Pulmonology (2022)

The diagnosis of airway obstruction can be made through FEV1/FVC ratio <0.7 or FEV1/VC ratio < lower limit of normality (LLN). Several authors advocate that FEV1/FEV6 ratio is an alternative to diagnosing obstructive ventilatory defect, while others have determined that the best cut-off for this ratio (best combined sensitivity and specificity) is 0.73. To evaluate the non-inferiority of FEV1/FEV6 ratio < 0.73 when compared to FEV1/FVC ratio < 0.7 and FEV1/VC < LLN in diagnosing airway obstruction. A retrospective analysis of the medical records from patients who underwent spirometry or plethysmography in a university central hospital from June 1st to December 31st, 2018 was carried out. Only medical records which included FEV1/FVC < 0.7 or FEV1/VC < LLN were selected, and these results were compared to FEV1/FEV6 ratio. A total of 526 patients with obstructive ventilatory defect were identified by one of the two ratios described. Of these, 95.1%, 87.4% and 88.6% were obstructive by FEV1/FVC, FEV1/VC, and FEV1/FEV6 ratio, respectively. The positive predictive value (PPV) of FEV1/FEV6 in relation to FEV1/FVC ratio was 99.6% (p < 0.001) with a diagnostic efficacy of 92.8%, whereas the PPV of FEV1/FEV6 in relation to FEV1/VC was 91.0% (p < 0.001) and diagnostic efficacy was 85.2%. Most false negatives, comparing FEV6 with the other two tests, were found in patients with FEV1 > 70% (mild obstruction) and in individuals aged >50 years. FEV1/FEV6 < 0.73 may be a good alternative ratio, as it is non-inferior to FEV1/VC and FEV1/FVC in diagnosing obstructive ventilatory defect.
The Editors’ Choice
Authors: Zuhair K. Ballas
Journal: Journal of Allergy and Clinical Immunology (2020)

SARS-CoV-2 has led to the COVID-19 global pandemic. Respiratory allergy and allergic asthma have not been identified as significant risk factors for COVID-19 despite their well-known association with more severe respiratory viral illnesses. Angiotensin-converting-enzyme 2 (ACE2) is the receptor for SARS-CoV-2 infections. Jackson et al (p 203), in this Letter to the Editor, aimed to determine whether respiratory allergy, allergic asthma, and/or controlled allergen exposure were associated with reductions in ACE2 gene expression, hypothesizing that this could reduce risk of COVID-19.
Novel strain of <i>Pseudoruminococcus massiliensis</i> possesses traits important in gut adaptation and host-microbe interactions
Authors: Kaisa Hiippala, Imran Khan, Aki Ronkainen, Fredrik Boulund, Helena Vähä-Mäkilä, Maiju Suutarinen, Maike Seifert, Lars Engstrand, Reetta Satokari
Journal: Gut Microbes (2021)

Fecal microbiota transplantation (FMT) is an efficient treatment for recurrent Clostridioides difficile infection and currently investigated as a treatment for other intestinal and systemic diseases. Better understanding of the species potentially transferred in FMT is needed. We isolated from a healthy fecal donor a novel strain E10-96H of Pseudoruminococcus massiliensis, a recently described strictly anaerobic species currently represented only by the type strain. The whole genome sequence of E10-96H had over 98% similarity with the type strain. E10-96H carries 20 glycoside hydrolase encoding genes, degrades starch in vitro and thus may contribute to fiber degradation, cross-feeding of other species and butyrate production in the intestinal ecosystem. The strain carries pilus-like structures, harbors pilin genes in its genome and adheres to enterocytes in vitro but does not provoke a proinflammatory response. P. massiliensis seems to have commensal behavior with the host epithelium, and its role in intestinal ecology should be studied further.
Classic Pages
Journal: Circulation Research (1969)

ACADEMIfc DES SCIENCES.'•/' le serum le plus actif est celui qu'on recueille environ ao heures apres la saignee.6° Enfln, si Ton fait a l'animal fournisseur de serum une serie de saignees successives, on constate les Tails suivants : si I'intervalle est suffisant, I'activite hemopoietique apparalt apres chaque nouvelle saignee, tout en diminuant legerement: en , pareil cas, la renovation du sang de l'animal saigne se fait normalemenl; mais, si I'intervalle des saignees esl trop rapproche, l'activite hemopoietique baisse rapidement, a , ', chaque nouvelle saignee; on peut meme observer, apres un trop grand nombre de , saignees, que I'injection de serum a un animal neuf provoque, non plus une aug-; mentation, mais au contraire une diminution des hematies ; il semble que I'activite hemopoietique du serum estcompensee par une activity hemolytique inverse el que ' , celle-ci devient alors preponderant ; on constate, parallelement, que le sang de -* l'animal saigne est, alors, incapable de se regenerer et que parfois la deglobulisalion, amorcee par les saignees, se continue spontanement.
ACME: Automatic feature extraction for cell migration examination through intravital microscopy imaging
Authors: Miguel Molina-Moreno, Iván González-Díaz, Jon Sicilia, Georgiana Crainiciuc, Miguel Palomino-Segura, Andrés Hidalgo, Fernando Díaz-de-María
Journal: Medical Image Analysis (2022)

Cell detection and tracking applied to in vivo fluorescence microscopy has become an essential tool in biomedicine to characterize 4D (3D space plus time) biological processes at the cellular level. Traditional approaches to cell motion analysis by microscopy imaging, although based on automatic frameworks, still require manual supervision at some points of the system. Hence, when dealing with a large amount of data, the analysis becomes incredibly time-consuming and typically yields poor biological information. In this paper, we propose a fully-automated system for segmentation, tracking and feature extraction of migrating cells within blood vessels in 4D microscopy imaging. Our system consists of a robust 3D convolutional neural network (CNN) for joint blood vessel and cell segmentation, a 3D tracking module with collision handling, and a novel method for feature extraction, which takes into account the particular geometry in the cell-vessel arrangement. Experiments on a large 4D intravital microscopy dataset show that the proposed system achieves a significantly better performance than the state-of-the-art tools for cell segmentation and tracking. Furthermore, we have designed an analytical method of cell behaviors based on the automatically extracted features, which supports the hypotheses related to leukocyte migration posed by expert biologists. This is the first time that such a comprehensive automatic analysis of immune cell migration has been performed, where the total population under study reaches hundreds of neutrophils and thousands of time instances.
Malignant External Otitis in a Patient With Diabetes Mellitus
Authors: Nasim Noroozbeigi, Vahid Reza Dabbagh, Zahra Pakdin Parizi, Samira Soltani, Ramin Sadeghi
Journal: Clinical Nuclear Medicine (2022)

Abstract We reported a 66-year-old woman with malignant external otitis who was referred to our department for evaluation of disease extension. Both 99m Tc-MDP bone SPECT/CT and 68 Ga-citrate PET/CT were done for the patient. Both studies showed concordant areas of increased uptake in the petrous bone. In addition, 68 Ga-citrate PET/CT showed soft tissue infection in the nasopharyngeal wall. Our case showed the potential of 68 Ga-citrate PET/CT for evaluation of malignant external otitis.
Intermittent high-dose intravenous interferon alpha 2b (IFNa2b) for adjuvant treatment of stage III malignant melanoma: An interim analysis of a randomized phase III study (NCT00226408)
Authors: P. Mohr, A. Hauschild, A. Enk, U. Trefzer, K. Rass, S. Grabbe, N. H. Brockmeyer, J. Koller, H. Gogas, M. Weichenthal
Journal: Journal of Clinical Oncology (2008)

9040 Background: Adjuvant high-dose interferon (HDI) treatment of patients with malignant melanoma (MM) usually consists of an initial intravenous (iv) application of 20 Mio IU/m² IFNa2b followed by 11 months of 10 Mio IU/m² subcutaneously (sc). Up to now it is unclear whether both components are necessary for the efficacy of HDI treatment in high-risk MM patients. The adjuvant phase III DeCOG MM-ADJ-5 trial evaluates efficacy, safety, and tolerability of a pulsed high-dose intravenous IFNa2b regimen. Methods: Patients with stage III (AJCC 2002) resected malignant melanoma were randomly assigned to receive either 3 courses of IFNa2b 20 Mio IU/m² iv on 5 days a week for 4 weeks repeated every 4 months (Arm B) or the standard HDI regimen consisting of one 4 week iv course followed by 11 month of 10 MU/m² IFN a2b sc 3 times a week (Arm A). Distant metastasis free survival (DMFS) was chosen as primary endpoint for efficacy analysis. A planned interim analysis was performed after 33% of the estimated rate of distant metastasis events had been reached. With a planned recruitment of 600 patients and an estimated event rate of 50% during follow-up, there were 380 patients evaluable, when a total of 101 distant metastasis events had been reported. Results: Out of 380 patients who were evaluable, 3 patients had to be excluded from intent-to-treat analysis because of substancial protocol deviations. The remaining 377 patients were well balanced between both arms according to sex, age, and stage (IIIa: 27.0% vs 29.2%; IIIb: 43.4% vs. 45.3%; IIIc: 29.7% vs. 25.5%) Distant metastasis occurred in 48 (Arm A; 25.9 %) vs. 53 (Arm B; 27.6 %) patients without statistical difference (p=0.73). The DMFS interval was not significantly different between both arms (p=0.45; log rank test). Termination of treatment due to adverse events or impairment of patients quality of life occurred significantly more often in arm A than in arm B. (20.5% vs. 11.5%; p=0.01) Conclusions: A planned interim analysis of pulsed adjuvant HDI treatment showed no significant efficacy differences as compared to conventional HDI. There is a clear trend for a favourable safety profile and improved health related quality of life measures in the pulsed regimen. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Schering-Plough Schering-Plough Schering-Plough