tbuckley/cabot-search huggingface dataset:
Abstract 421: Cardiac Hypertrophy Induced by Swimming Exercise in Mice and the Cardiac Renin-Angiotensin System: The More, the Better?
Authors: Santiago Alonso L Tobar, Douglas S Soares, Graziela H Pinto, Daniel S Caetano, Amanda Lopes, Michael E Andrades, Nadine O Clausell, Luis Eduardo P Rohde, Andréia Biolo
Journal: Circulation Research (2017)

Cardiac hypertrophy is an adaptive process which is triggered by different mechanism in order to improve blood flow to organism and it may progress as physiological or pathological. Physical exercise offers a wide range hemodynamic stimulus; consequently it may modulate several molecular mechanisms associated to cardiac hypertrophy, for instance the local cardiac renin-angiotensin system (RAS). Thus, the aim of this study was to analyze the classical (ANGII/AT1) and alternative (ANG1-7/MAS) axis of the RAS in the cardiac muscle of mice submitted to exercise with different volumes/intensity training for the development of cardiac hypertrophy. Therefore, male Balb/c mice were divided in three groups: (i) Sedentary (SED), (ii) swimming training twice a day (T2), and (iii) swimming training three times a day with 2% of body weight overload (T3), for six weeks of training. The cardiac hypertrophy was assessed by the left ventricle weight and tibial length (LV/mm) ratio and cardiomyocytes cross-sectional area. Angiotensin peptides were analyzed by HPLC and angiotensin receptor measured by western blotting. We have also analyzed fibrosis by masson’s tricrome and the fetal genes reactivation was assessed by qRT-PCR. Both swimming training induced cardiac hypertrophy, the CHI for groups was T2 (6.34±0.44 mg/mm) and T3 (6.74 ± 0.70 mg/mm) compared to SED (5.55±0.5 mg/mm, p = 0.002). There was no observed change in the levels of angiotensin peptides ANG-I, ANG-II, and ANG1-7 between training groups and sedentary, however when we analyze angiotensin receptors, group T3 showed higher levels of AT1 when compared to SED (p=0.004), while MASR levels was higher in T2 compared to SED (0.017). Further, there was moderate reactivation of fetal genes as evidenced by increased in MHC-β expression observed in T3, but without fibrosis in either group. Our results suggest that increasing volumes/intensity of exercise beyond moderate does not influence the magnitude or the structural phenotype of physiological cardiac hypertrophy. However, it might promote the activation of molecular mechanisms involved in pathological cardiac hypertrophy.
<scp>Angiotensin–neprilysin</scp> inhibition and renal outcomes across the spectrum of ejection fraction in heart failure
Authors: Finnian R. Mc Causland, Martin P. Lefkowitz, Brian Claggett, Milton Packer, Michele Senni, Mauro Gori, Pardeep S. Jhund, Martina M. McGrath, Jean L. Rouleau, Victor Shi, Karl Swedberg, Muthiah Vaduganathan, Faiez Zannad, Marc A. Pfeffer, Michael Zile, John J.V. McMurray, Scott D. Solomon
Journal: European Journal of Heart Failure (2022)
Productivity loss outcomes and indirect costs among patients (Pts) with cholangiocarcinoma (CCA).
Authors: Anna Teschemaker, Ellen Thiel, Julie Park, Shreekant Parasuraman
Journal: Journal of Clinical Oncology (2022)

392 Background: CCA pts, often diagnosed at older age with advanced disease, face poor prognoses and economic burden. Despite increasing CCA incidence in working age pts, little is known on financial impact on working pts. This study describes the impact of CCA on productivity loss and indirect costs due to workplace absence, short-term disability (STD), and long-term disability (LTD). Methods: Retrospective claims data from IBM MarketScan Commercial and Health and Productivity Management (HPM) databases between 7/1/2010 to 12/31/2019 were used. Eligible pts were ≥18 years, had ≥1 non-ruleout claim for CCA ( ICD-9/ -10: intrahepatic [iCCA]: 155.1/C221; extrahepatic [eCCA]: 156.1, 156.9/C240, C249) in the index period (1/1/2011 – 12/31/2019), and had ≥6 months of continuous medical and pharmacy benefit enrollment before and ≥1 month of follow-up and full-time employee eligibility after index date. Productivity loss as absenteeism, STD, and LTD among iCCA and eCCA was reported per pt per month (PPPM) for a work month of 21 days. Absenteeism was defined as absence days for illness; STD and LTD were defined as days on disability leave. Indirect cost was estimated using wage equivalent to median hourly wage rate and salary replacement rate of 70% from US Bureau of Labor and Statistics. Results: A total of 1065 CCA pts (iCCA, n=624 [58.6%]; eCCA, n=380 [35.7%]) were identified. The number of productivity benefit–eligible pts for analysis in absenteeism, STD, and LTD were 107, 617, and 549, respectively. Across cohorts, mean age ranged from 51.9 to 53.9 years; &gt;60% were men. Mean (SD) follow-up time (days) was 725.0 (730.4) for absenteeism, 639.7 (587.0) for STD, and 614.4 (583.2) for LTD. The most notable comorbidities across cohorts were moderate/severe liver disease (58–63%) and pain (67–71%). Among pts with productivity claims, more CCA-related absences and higher related indirect costs were observed in iCCA than eCCA pts. The trend in all-cause disability outcomes of STD, LTD, and related costs was less clear between iCCA and eCCA pts; however, medical costs were higher in iCCA pts. Conclusions: CCA pts had high productivity loss and indirect costs, which is pt costs due to days missed from work in addition to medical costs; iCCA pts incurred substantially more absences, related indirect costs, and medical costs than eCCA pts.[Table: see text]
AKI in Hospitalized Patients with COVID-19
Authors: Lili Chan, Kumardeep Chaudhary, Aparna Saha, Kinsuk Chauhan, Akhil Vaid, Shan Zhao, Ishan Paranjpe, Sulaiman Somani, Felix Richter, Riccardo Miotto, Anuradha Lala, Arash Kia, Prem Timsina, Li Li, Robert Freeman, Rong Chen, Jagat Narula, Allan C. Just, Carol Horowitz, Zahi Fayad, Carlos Cordon-Cardo, Eric Schadt, Matthew A. Levin, David L. Reich, Valentin Fuster, Barbara Murphy, John C. He, Alexander W. Charney, Erwin P. Böttinger, Benjamin S. Glicksberg, Steven G. Coca, Girish N. Nadkarni
Journal: Journal of the American Society of Nephrology (2020)

Early reports indicate that AKI is common among patients with coronavirus disease 2019 (COVID-19) and associated with worse outcomes. However, AKI among hospitalized patients with COVID-19 in the United States is not well described.
A multi-institutional study of the impact of the COVID-19 pandemic on pancreatic cancer diagnosis and management.
Authors: Claudia Rosso, Jennifer B. Valerin, Parisa Oviedo, Niloofar Radgoudarzi, Wen-Pin Chen, Christine E. McLaren, Rebekah Ruth White, Jason Zell
Journal: Journal of Clinical Oncology (2022)

526 Background: The impact of COVID-19 on cancer patients may be attributed not only to its direct effects on the immune system but also to delays in diagnosis and treatment. Data on the effects of COVID-19 on pancreatic ductal adenocarcinoma (PDAC) patients are scarce. Therefore, we set out to determine the impact of the pandemic on diagnosis and treatment initiation. We hypothesized that time from diagnosis to treatment would be increased in the COVID era compared to the pre-COVID era. Methods: We conducted an IRB-approved retrospective chart review of 488 patients diagnosed with PDAC from March 2019 to September 2020 at two academic medical centers. Patients were divided into two groups, based on the date of initial pathologic diagnosis. We defined the pre-COVID era as March 2019 to March 2020, the 12-month time period before California’s statewide lockdown. The COVID era was defined as the 6 months following the lockdown, March 2020 to September 2020. Demographics, clinical stage, and treatment type were recorded. In addition, initial clinical encounter date, pathologic diagnosis date, and initial treatment date were also collected. All data were gathered at two large-scale academic institutions. Descriptive statistics were used in the analysis. Results: There were 333 patients diagnosed during the pre-COVID era and 155 patients during the COVID era. While race/ethnicity and age at diagnosis were statistically similar for both groups, females made up a significantly larger proportion of COVID era patients than pre-COVID era patients ( p= 0.02). There was no significant difference in clinical stage at diagnosis between the two groups ( p= 0.84). In the pre-COVID era, 19.5% of cases were resectable, 11.1% borderline resectable, 20.1% locally advanced, and 31.8% metastatic. In the COVID era, 17.4% of patients were resectable, 11% borderline resectable, 23.9% locally advanced, and 32.9% metastatic. Median time from pathologic diagnosis to initiation of treatment was 32 days for the pre-COVID era patients and 28 days for the COVID era patients ( p= 0.38). Initial treatment type was also similar between the two groups ( p= 0.29). Conclusions: Fortunately, our data indicate that the COVID-19 pandemic has not significantly prevented PDAC patients from seeking care. Additionally, it does not appear that COVID-19 has delayed treatment initiation or changed initial treatment type. We believe that the successful adoption of telemedicine and other safety protocols have allowed patients with PDAC to continue receiving appropriate care during the pandemic.[Table: see text]
Tumors resurrect an embryonic vascular program to escape immunity
Authors: Elisabeth J. M. Huijbers, Kabir A. Khan, Robert S. Kerbel, Arjan W. Griffioen
Journal: Science Immunology (2022)

Tumors can escape immunity through multiple mechanisms, one of which is by enforcing a state of unresponsiveness of the tumor vasculature to inflammatory cytokines. This results in a lack of adhesiveness of angiogenic endothelial cells for immune cells and thus compromised immunity. This type of escape from immunity, called tumor endothelial cell anergy, is the result of exposure to angiogenic growth factors. Angiogenesis is a hallmark not only of cancer but also of embryonic development. It is assumed that angiogenesis-induced suppression of adhesion molecules is a regulatory function to provide an embryo with immune privileged conditions and allow uninterrupted growth and development. It is becoming clear that similar conditions are used by tumors to evade the immune system and ensure progressive growth. Gaining enhanced insight into these immune-privileged conditions is important as endothelial cell anergy can be overcome by angiogenesis inhibitors, an application that is rapidly emerging as a successful strategy to improve immunotherapy. The literature on endothelial adhesion molecule expression and leukocyte-vessel wall interactions during embryonic and fetal development is sparse, but available data allow the hypothesis that tumors, through angiogenesis, enforce an embryonic-like gene expression program in endothelial cells to suppress leukocyte infiltration and compromise antitumor immunity.
In This Issue
Journal: American Journal of Psychiatry (2012)

Insurance Exchange Coverage of the Mentally IllMechanisms to compensate insurance plans covering disproportionate numbers of chronically mentally ill patients in the planned health insurance exchanges are generally adequate, according to an analysis of past claims data (figure).After implementation of the Affordable Care Act (ACA) in 2014, report Barry et al. (p.704), financial solvency will be largely ensured through "risk adjustment" by a pool of contributions from all plans in the state.The ACA also designates two temporary measures: commercial reinsurance purchased by each plan for costs above a certain threshold and "risk corridors" of payments flowing from the federal government to plans with higher than expected costs, in conjunction with payments coming in from plans with lower costs.In their editorial, Garfield and Druss (p.675) note that some plans may still be underpaid despite these provisions, and they describe the ramifications of "adverse selection," incentives for mentally ill patients to choose particular health insurance plans.
Are risk factors for sudden death in myocardial infarction patients treated with percutaneous coronary intervention different? Analysis of the PAMI database Bohuslav Finta, Howard Frumin, Judy Boura, Gregg W. Stone, Bruce R. Brody, David A. Cox, Eulogio Garcia, Lori L. Grines, Kimberly A. Skelding, Cindy L. Grines. William Beaumont Hospital, Royal Oak, MI
Journal: Journal of the American College of Cardiology (2001)
Editorial Board
Authors: Donald Leung, Stanley Szefler, Colo Associate, Andrea Apter, Pedro Philadelphia, Joshua Avila, Boston Boyce, Robert Bush, Fred Finkelman, Cincinnati Ohio, Dennis Ledford, Tampa Fla, Deborah Meyers, Luigi Notarangelo, David Peden, Chapel Hill, Harald Renz, Marburg Germany, Marc Rothenberg, William Shearer, Scott Sicherer, New York, Erika Von Mutius, Statistics Editor, Vernon Chinchilli
Journal: Journal of Allergy and Clinical Immunology (2013)
ANTHOCYANINURIA
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heterogeneity of DKA Incidence and Age-Specific Clinical Characteristics in Children Diagnosed With Type 1 Diabetes in the TEDDY Study
Authors: Laura M. Jacobsen, Kendra Vehik, Riitta Veijola, Katharina Warncke, Jorma Toppari, Andrea K. Steck, Patricia Gesualdo, Beena Akolkar, Markus Lundgren, William A. Hagopian, Jin-Xiong She, Marian Rewers, Anette-G. Ziegler, Jeffrey P. Krischer, Helena Elding Larsson, Michael J. Haller
Journal: Diabetes Care (2022)

OBJECTIVE The Environmental Determinants of Diabetes in the Young (TEDDY) study is uniquely capable of investigating age-specific differences associated with type 1 diabetes. Because age is a primary driver of heterogeneity in type 1 diabetes, we sought to characterize by age metabolic derangements prior to diagnosis and clinical features associated with diabetic ketoacidosis (DKA). RESEARCH DESIGN AND METHODS The 379 TEDDY children who developed type 1 diabetes were grouped by age at onset (0–4, 5–9, and 10–14 years; n = 142, 151, and 86, respectively) with comparisons of autoantibody profiles, HLAs, family history of diabetes, presence of DKA, symptomatology at onset, and adherence to TEDDY protocol. Time-varying analysis compared those with oral glucose tolerance test data with TEDDY children who did not progress to diabetes. RESULTS Increasing fasting glucose (hazard ratio [HR] 1.09 [95% CI 1.04–1.14]; P = 0.0003), stimulated glucose (HR 1.50 [1.42–1.59]; P &amp;lt; 0.0001), fasting insulin (HR 0.89 [0.83–0.95]; P = 0.0009), and glucose-to-insulin ratio (HR 1.29 [1.16–1.43]; P &amp;lt; 0.0001) were associated with risk of progression to type 1 diabetes. Younger children had fewer autoantibodies with more symptoms at diagnosis. Twenty-three children (6.1%) had DKA at onset, only 1 (0.97%) of 103 with and 22 (8.0%) of 276 children without a first-degree relative (FDR) with type 1 diabetes (P = 0.008). Children with DKA were more likely to be nonadherent to study protocol (P = 0.047), with longer duration between their last TEDDY evaluation and diagnosis (median 10.2 vs. 2.0 months without DKA; P &amp;lt; 0.001). CONCLUSIONS DKA at onset in TEDDY is uncommon, especially for FDRs. For those without familial risk, metabolic monitoring continues to provide a primary benefit of reduced DKA but requires regular follow-up. Clinical and laboratory features vary by age at onset, adding to the heterogeneity of type 1 diabetes.
No agreement on diets for 'hyperactive' kids
Authors: Barbara Bolsen
Journal: JAMA (1982)

Does diet have an effect on childhood hyperactivity? The question has been the subject of controversy since 1973 when Ben Feingold, MD, first proposed that it does. Feingold, chief emeritus, Department of Allergy, Kaiser-Permanente Medical Center, San Francisco, has reported clinical observations that 40% to 50% of hyperactive children become less so when given a diet free of artificial flavorings, artificial dyes, and foods containing naturally occurring salicylates. He believes that hyperactivity is the result of "activation of the biological or genetic profile by an agent in the environment." Since the 1975 publication of his book<i>Why Your Child Is Hyperactive</i>(New York, Random House), thousands of parents have put their hard-to-manage hyperactive children on the Feingold diet, while a handful of investigators have conducted controlled, double-blind studies to test his hypothesis. Results have been subject to conflicting interpretations. As recently as October 1980, a national advisory committee sponsored by
When Asked . . .
Authors: M. DAVID WARD
Journal: Annals of Internal Medicine (1982)

Ad Libitum1 September 1982When Asked . . .M. DAVID WARD, M.D.M. DAVID WARD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-3-458_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhen asked how I go onI say these patients on my roundsare my pictures at an exhibition.To sadden or delight or horrify,they fix my attentionperplex or move mefully.But for allotted time only.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: West Hartford, Connecticut PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1982Volume 97, Issue 3Page: 458-458 ePublished: 1 December 2008 Issue Published: 1 September 1982 PDF downloadLoading ...
Association between $beta;1-adrenergic receptor gene polymorphism and ventricular tachycardia in patients with dilated cardiomyopathy Chikao Iwai, Hozuka Akita, Nobuyuki Shiga, Yasuaki Matsuda, Elji Takai, Yoshitomo Miyamoto, Masakatsu Shimizu, Hiroya Kawai, Akira Takarada, Mitsuhiro Yokoyama. The 1st Dept. of Internal Medicine, Kobe University School of Medicine, Kobe, Japan, Dept. of Cardiology, Himeji Cardiovascular Center, Himeji, Japan
Journal: Journal of the American College of Cardiology (2001)
Discovery of an unpublished manuscript
Authors: R. Armour
Journal: JAMA (1968)

Recently I bought an old medical book in a bookstore. I bought it not because of interest in the subject but because it was on a table that bore the sign: "Any book 500." It was a big, sturdy volume, and I thought it might suit my purpose. I needed something about 2 inches thick to put under a potted plant in our den. It turned out to be just the right size, and the brown binding went rather nicely with the deep red of the flower pot. The only trouble was that the plant tilted slightly, no matter which way I turned it. It was then that I noticed several sheets of paper folded and tucked inside the back cover of the book. Once I had removed the wedge of paper, the plant stood up as straight as you please. I was about to throw away the half dozen
See-Saw Nystagmus
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Malignant transformation in vitro by oncogenic viruses
Authors: P. H. Black
Journal: JAMA (1968)

In vitro transformation of animal cells by oncogenic viruses offers a controlled methodology with which to study the malignant process. Quantitative studies of viral transformation reveal that up to 50% of cells can be transformed. Examination of the early biochemical events of viral transformation has disclosed that an induction of synthesis of enzymes operative in deoxyribonucleic acid biosynthetic pathways and a stimulation of host DNA synthesis occurs from 12 to 24 hours after infection of the cells. There is an association of these changes, resulting from a disruption of the regulatory mechanisms of host cell metabolism, with viral transformation. There is
Similar Findings on 18F-MFBG PET/CT and 68Ga-DOTATATE PET/CT in a Patient With Widespread Metastatic Pheochromocytoma
Authors: Peipei Wang, Guozhu Hou, Hongli Jing, Hongming Zhuang, Fang Li
Journal: Clinical Nuclear Medicine (2022)

Abstract A 27-year-old woman with known malignant pheochromocytoma was enrolled in a clinical trial to compare efficacy of 68 Ga-DOTATATE PET/CT and 18 F-MFBG PET/CT. Images from both studies detected similar number of the metastatic lesions. In addition, both studies detected more lesions than 131 I-MIBG imaging.
Alteration of atrial electrophysiology in patients with heart failure. An electromagnetic mapping study with monophasic action potentials Juergen Schreieck, Martin R. Karch, Bernhard Zrenner, Sebastian Schmieder, Michael Messerschmidt, Claus Schmitt. Deutsches Herzzentrum Muenchen, Technische Universitaet Muenchen, Munich, Germany
Journal: Journal of the American College of Cardiology (2001)
Segregation of tuberculosis patients.
Journal: BMJ (1967)

BRMSH 3The local organization is to be based on hospital meetings, and these will elect the regional committees.The larger regions will have bigger regional committees who, in turn, will appoint a larger number of representatives on the Group Council.These new arrangements give ample scope for democracy to work.The Hospital Junior Staffs Group Council should be able in future fairly to claim that it represents all hospital junior doctors.Its executive committee is to appoint 12 members of the Central Committee for Hospital Medical Services, and this committee is in future to be responsible, through a Negotiating Subcommittee, for remuneration and all terms of service for all hospital doctors.2Three of the Central Committee's nine representatives on the Negotiating
Angiotensin converting enzyme genotyping and coronary restenosis Henning Kelb�k, Erik J�rgensen, Steffen Helqvist, Jens Kastrup, Kari Saunam�ki, Jan K. Madsen, Gunnar V. H. Jensen, Lene Kl�vgaard, Henning Bundgaard, Ole Havndrup, Michael Christiansen, Paal S. Andersen, Anton v. Weert, Hans Reiber. Cardiac Cath Lab, Rigshospitalet, Copenhagen, Denmark
Journal: Journal of the American College of Cardiology (2001)