tbuckley/cabot-search huggingface dataset:
COVID-19 and Vitamin D in an Urban US Hemodialysis Population
Authors: Derrick E. Ridley, Anjana Easwar, Omar Syed, Marcellus Edwards, Spencer A. King, Rosie Jardina, Jose E. Navarrete, Harold A. Franch, Janice P. Lea, Jason Cobb
Journal: Journal of the American Society of Nephrology (2021)

Background: Due to logistical constraints of in-center hemodialysis (HD) ESKD patients have endured increased risk during the COVID-19 pandemic. Minorities are overrepresented in EKSD, making this group more susceptible to poor outcomes given existing racial disparities. Studies have emerged spotlighting vitamin D's effects on autocrine regulation of immune function and the relevance of extra-renal one alpha hydroxylase. Many studies describe links between vitamin D deficiency and severity of SARS-CoV-2 infection in high-risk patients, but there is a paucity of data specific to ESKD patients. This study explored the association between vitamin D status and COVID-19 infection in a primarily black HD population. Methods: Emory Dialysis patients' vitamin D levels [25(OH) D] were collected November 2020 as part of a quality improvement project. All SARS-CoV-2 positive HD patients were identified (October 2020 to April 2021). Retrospective chart review including baseline data and labs were collected. An unpaired t-test was used to compare vitamin D levels between COVID-19 positive and negative patients. Results: 620 patients were included. All patients enrolled in-center HD three times per week. Patient identified race makeup included black (n=570) and non-black n= 50. Average age was 59 years. Gender: males (n=324) and females (n=296). 73 patients developed COVID-19 and 68 patients identified as black race. Average vitamin D levels for COVID-19 positive patients 27.33 and COVID-19 negative patients 26.2 (p=0.55). Average PTH in COVID-19 positive patients 507.3±371 and COVID-19 negative patients 557.57±458 (p=0.25). Average calcium level in COVID-19 positive patients 8.74±0.66 and COVID-19 negative patients 8.73±0.72 (p=0.48). Relative risk of developing COVID-19 in black HD patients was 1.14 compared to others (p=0.75). Conclusions: Our study showed no statistically significant correlation between Vitamin D level and COVID-19 acquisition. The role of vitamin D deficiency as a risk factor and the role of Vitamin D supplementation for prevention or treatment COVID-19 in this population is unclear. Further studies investigating the relation between Vitamin D levels and severity of COVID-19 infection in this population should be explored.
Inhibition of S-Adenosylmethionine Synthesis Promotes Erythropoiesis Via Epigenetic Modifications
Authors: Hiroki Kato, Nguyen Chi Long, Yusho Ishii, Mitsuyo Matsumoto, Catherine Rhee, Daisuke Saigusa, Ryo Funayama, Hiroaki Okae, Tohru Fujiwara, Akihiko Muto, Hideo Harigae, David T. Scadden, Kazuhiko Igarashi
Journal: Blood (2021)
Abstract 16314: Angiotensin II Activated-Protein Phosphatase 2A Dephosphorylates Endothelial NO Synthase via AT1 Receptor-Mediated Signaling Pathway in Human Umbilical Vein Endothelial Cells
Authors: Ming Yu, Yanbei Luo, Juncai Jiang, Qian Zhang, Jing Ding, Deqin Lu
Journal: Circulation (2018)

Evidence suggests that angiotensin (Ang) II contributes to the development of cardiovascular diseases through multiple signaling pathways including angiotensin type 1 receptor (AT1R) -mediated NADP...
Children in the United States with Sickle Cell Disease Experience Greater Educational Burden Than Those Living in Low/Middle Income and Other High-Income Countries
Authors: Fuad El Rassi, John James, Biree Andemariam, Beverley Francis-Gibson, Caterina P Minniti, Jincy Paulose, Tom Bailey, Olivera Rajkovic-Hooley, Ifeyinwa Osunkwo
Journal: Blood (2021)
An Extracellular Matrix‐Liposome Composite, a Novel Extracellular Matrix Delivery System for Accelerated Tissue Regeneration
Authors: Keel Yong Lee, Huong Thanh Nguyen, Agustina Setiawati, So‐Jung Nam, Minyoung Kim, Il‐Gyu Ko, Won Hee Jung, Kevin K. Parker, Chang‐Ju Kim, Kwanwoo Shin
Journal: Advanced Healthcare Materials (2021)

The unfolded states of fibronectin (FN) subsequently induce the formation of an extracellular matrix (ECM) fibrillar network, which is necessary to generate new substitutive tissues. Here, the authors demonstrate that negatively charged small unilamellar vesicles (SUVs) qualify as candidates for FN delivery due to their remarkable effects on the autonomous binding and unfolding of FN, which leads to increased tissue regeneration. In vitro experiments revealed that the FN-SUV complex remarkably increased the attachment, differentiation, and migration of fibroblasts. The potential utilization of this complex in vivo to treat inflammatory colon diseases is also described based on results obtained for ameliorated conditions in rats with ulcerative colitis (UC) that had been treated with the FN-SUV complex. Their findings provide a new ECM-delivery platform for ECM-based therapeutic applications and suggest that properly designed SUVs may be an unprecedented FN-delivery system that is highly effective in treating UC and inflammatory bowel diseases.
Comparing Outcomes between Liposomal Daunorubicin/Cytarabine (CPX-351) and HMA+Venetoclax As Frontline Therapy in Acute Myeloid Leukemia
Authors: Justin Grenet, Akriti G Jain, Madelyn Burkart, Julian Waksal, Christopher Famulare, Yazan Numan, Maximilian Stahl, Zoe Mckinnell, Brian Ball, Xiaoyue Ma, Paul J Christos, Ellen Ritchie, Michael B. Samuel, Justin D. Kaner, Sangmin Lee, Aaron D Goldberg, Shira Dinner, Kendra Sweet, Gail J. Roboz, Pinkal Desai
Journal: Blood (2021)
Randomized, Multi-Center, Double-Blinded, Placebo Controlled Safety and Early Efficacy Trial of Cryopreserved Cord Blood Derived T-Regulatory Cell Infusions (CK0802) in the Treatment of COVID-19 Induced ARDS. (RESOLVE Trial)
Authors: Douglas E Gladstone, Christopher Howard, Mi-Ae Lyu, Jason Mock, Darryl Adams, Kevin Gibbs, Li Li, Meixian Huang, Ke Zeng, Franco D'Alessio, James Herlihy, Sergio Trevino, Parameswaran Hari, Tara Sadeghi, Simrit Parmar, Arthur Slutsky, Siddhartha Mukherjee
Journal: Blood (2021)
Sustainable Efficacy and Safety Results from Lummicar Study 1: A Phase 1/2 Study of Fully Human B-Cell Maturation Antigen-Specific CAR T Cells (CT053) in Chinese Subjects with Relapsed and/or Refractory Multiple Myeloma
Authors: Wenming Chen, Chengcheng Fu, Zhen Cai, Zonghai Li, Huijuan Wang, Lingzhi Yan, Yin Wu, Xiaolan Shi, Wen Gao, Shuang Yan, Wei Wang, Xiaoyan Han, Gaofeng Zheng, Yanling Wen, Jun Xiao, Huamao Wang, Xiaole Tang
Journal: Blood (2021)
Potent Ikaros Degradation By the Cereblon E3 Ligase Modulator CC-92480 Is Effective in Combination with Menin-MLL1 Inhibition in <i>MLL1</i>-Rearranged and <i>NPM1</i>-Mutant AML
Authors: Wallace Bourgeois, Brandon J. Aubrey, Jevon A. Cutler, Katherine A. Donovan, Charles Hatton, Alexandra C. P. Theall, Radoslaw P. Nowak, Gerard M. McGeehan, Eric S. Fischer, Scott A. Armstrong
Journal: Blood (2021)
Distribution and density of tertiary lymphoid structures predict clinical outcome in intrahepatic cholangiocarcinoma
Authors: Guang-Yu Ding, Jia-Qiang Ma, Jing-Ping Yun, Xing Chen, Yu Ling, Shu Zhang, Jie-Yi Shi, Yu-Qing Chang, Yuan Ji, Xiao-Ying Wang, Wei-Min Tan, Ke-Fei Yuan, Bo Yan, Xiao-Ming Zhang, Fei Liang, Jian Zhou, Jia Fan, Yong Zeng, Mu-Yan Cai, Qiang Gao
Journal: Journal of Hepatology (2021)
IL-10R Inhibition Selects for Jak2V617F Hematopoiesis By Augmenting Inflammation Induced Exhaustion of Wild-Type but Not Jak2V617F Hematopoietic Stem Cells
Authors: Angela Fleischman, Hew Yeng Lai, Nitya Mehrota-Venkat, Tiffany Trieu, Tiffany Han, Gajalakshmi Ramanathan, Brianna Hoover
Journal: Blood (2021)
SERV-CT: A disparity dataset from cone-beam CT for validation of endoscopic 3D reconstruction
Authors: P.J. Eddie Edwards, Dimitris Psychogyios, Stefanie Speidel, Lena Maier-Hein, Danail Stoyanov
Journal: Medical Image Analysis (2021)

In computer vision, reference datasets have been highly successful in promoting algorithmic development in stereo reconstruction. Surgical scenes gives rise to specific problems, including the lack of clear corner features, highly specular surfaces and the presence of blood and smoke. Publicly available datasets have been produced using CT and either phantom images or biological tissue samples covering a relatively small region of the endoscope field-of-view. We present a stereo-endoscopic reconstruction validation dataset based on CT (SERV-CT). Two {\it ex vivo} small porcine full torso cadavers were placed within the view of the endoscope with both the endoscope and target anatomy visible in the CT scan. Orientation of the endoscope was manually aligned to the stereoscopic view. Reference disparities and occlusions were calculated for 8 stereo pairs from each sample. For the second sample an RGB surface was acquired to aid alignment of smooth, featureless surfaces. Repeated manual alignments showed an RMS disparity accuracy of ~2 pixels and a depth accuracy of ~2mm. The reference dataset includes endoscope image pairs with corresponding calibration, disparities, depths and occlusions covering the majority of the endoscopic image and a range of tissue types. Smooth specular surfaces and images with significant variation of depth are included. We assessed the performance of various stereo algorithms from online available repositories. There is a significant variation between algorithms, highlighting some of the challenges of surgical endoscopic images. The SERV-CT dataset provides an easy to use stereoscopic validation for surgical applications with smooth reference disparities and depths with coverage over the majority of the endoscopic images. This complements existing resources well and we hope will aid the development of surgical endoscopic anatomical reconstruction algorithms.
EXTH-42. COMBINATION OF MAPK PATHWAY INHIBITORS AND IMMUNE CHECKPOINT BLOCKADE IN BRAF-MUTANT HIGH-GRADE GLIOMA
Authors: Jong-Whi Park, Stefan Grossauer, Wei Wang, Mathieu Daynac, Sharon Pitteri, Michelle Monje, Gerald Grant, Claudia Petritsch
Journal: Neuro-Oncology (2021)

Abstract BACKGROUND Despite successes, clinical MAPK pathway inhibitors show limited anti-tumor activity in the majority of patients with BRAF-mutant high-grade glioma. Because of the presence of higher fraction of CD8+ tumor-infiltrating T cells in MAPK pathway-altered glioma, we explored the possibility that combined BRAF and MEK inhibition with immune checkpoint blockade enhances anti-tumor response. METHODS We engineered mice to carry BRAF V600E expression and CDKN2A deletion in various hemispheric areas. We treated syngeneic tumor-bearing mice with dabrafenib, trametinib, anti-PD-L1 and anti-CTLA-4 antibodies, and analyzed the tumor immune infiltrate by high-dimensional single-cell mass cytometry (CyTOF). RNA sequencing and Gene Set Enrichment Analysis were conducted using patient-derived BRAF-mutant glioma lines upon the inhibitor treatment. RESULTS The transcriptome analysis demonstrated that antigen processing and presentation feature is strongly enriched upon dual MAPK pathway inhibition. Consistent with these molecular changes, dabrafenib and trametinib treatment led to dynamic changes in tumor-infiltrating immune cells, including CD8+ and CD4+ T cells. In line with this, combination of MAPK pathway and immune checkpoint inhibitors elicit a significant survival benefit over MAPK pathway inhibition alone in mice with orthotopic BRAF-mutant glioma. CONCLUSIONS Clinically relevant molecular targeted therapy by dabrafenib and trametinib and immune checkpoint blockade synergize in pre-clinical models.
Cross-roads for meta-analysis and network meta-analysis of <i>H. pylori</i> therapy
Authors: David Y Graham, Ruben Hernaez, Theodore Rokkas
Journal: Gut (2021)

infections are responsible for tremendous morbidity and mortality worldwide, leading to efforts to eradicate the organism. However, the effectiveness of antimicrobial therapy has been undermined by the progressive development of antimicrobial resistance. Treatments and treatment guidelines have been based on traditional pairwise meta-analyses of randomised controlled trials. More recently, network meta-analyses have also been used in an attempt to provide useful information to the clinician regarding which therapies appear best and which to avoid as the least efficacious. However, both forms of meta-analysis have been undermined by the same problems including the poor quality of the clinical trials using unoptimised regimens and incomparable comparisons related to marked geographic and ethnic genotypic and phenotypic heterogeneity. In addition, the comparator regimens often consist of invalid strawman comparisons. New approaches concerning
Abstract 12011: Vascular Function in Leukemia Survivors After Hematopoietic Cell Transplantation
Authors: Donald R Dengel, Aaron S Kelly, Lei Zhang, James S Hodges, Julia Steinberger, K S Baker
Journal: Circulation (2015)

Introduction: Previously, we have documented the effects of radiation and/or chemotherapy on vascular structure and function in childhood cancer survivors. To date, little is known about the effects on vascular health of the hematopoietic cell transplantation (HCT) preparative regimen (total body irradiation [TBI] and high dose chemotherapy) that often accompanies this treatment. Hypothesis: HCT preparative regimens utilizing TBI would result in a decrement in arterial function in HCT survivors than those that did not utilize TBI. Methods: Measures of carotid artery stiffness (compliance, distensibility) and intima-media thickness (cIMT) were obtained from ultrasound imaging in patients who had survived &gt;2 years after HCT for hematologic malignancy and were diagnosed at age &lt;21 yrs. Siblings (n=122) were invited to participate as controls. A total of 87 HCT survivors were examined; 50 received TBI only, 17 received TBI plus central nervous system irradiation (TBI+CNS); another 20 received a chemotherapy only preparative regimen ([CHEMO], most busulfan + cyclophosphamide). Results: Although cIMT did not differ between siblings and HCT survivors, both carotid cross-sectional compliance (CSD) and carotid diameter distensibility (DD) were greater in siblings than HCT survivors (Table). Comparing the different HCT preparative regimens, cIMT did not differ significantly between siblings and the three preparative regimen groups. However, both CSD and DD were significantly lower in TBI+CNS and TBI subjects compared to siblings. Also, carotid incremental elastic modulus (IEM) was significant higher in TBI+CNS than in the TBI only, CHEMO, and sibling groups. Conclusion: These results demonstrate that HCT preparative regimens containing TBI result in greater arterial decrements indicating increased risk for premature atherosclerosis and cardiovascular disease. The addition of CNS radiation to TBI results in further decrements in arterial function.
Efficacy and Safety of Sabatolimab (MBG453) in Combination with Hypomethylating Agents (HMAs) in Patients (Pts) with Very High/High-Risk Myelodysplastic Syndrome (vHR/HR-MDS) and Acute Myeloid Leukemia (AML): Final Analysis from a Phase Ib Study
Authors: Andrew M. Brunner, Jordi Esteve, Kimmo Porkka, Steve Knapper, Elie Traer, Sebastian Scholl, Guillermo Garcia-Manero, Norbert Vey, Martin Wermke, Jeroen Janssen, Rupa Narayan, Sun Loo, Mika Kontro, Oliver Ottmann, Purushotham Naidu, Marc Pelletier, May Han, Andrew Lewandowski, Na Zhang, Anisa Mohammed, Mikael L. Rinne, Uma Borate, Andrew H. Wei, Natalia Tovar
Journal: Blood (2021)
Effects of the COVID-19 Pandemic on Caregivers of Young Children with Sickle Cell Disease Enrolled in the Engage-HU Trial
Authors: Anna M Hood, Aimee K Hildenbrand, Joanna Rebitski, Jasmine Stallworth, Yolanda Johnson, Stacey Gomes, Catharine Whitacre, Constance A Mara, Lisa M Shook, Charles T. Quinn, Jean L. Raphael, Amber M Yates, Sherif M. Badawy, Alexis A. Thompson, Kim Smith-Whitley, Helge Hartung, Allison A. King, Susan E Creary, Neha Bhasin, Steven K Reader, Emily R. Meier, Venee N. Tubman, Lori E. Crosby
Journal: Blood (2021)
Abstract 10860: Cardiotoxicity as an Adverse Effect of Immunomodulatory Drugs and Proteasome Inhibitors in Multiple Myeloma: A Meta-Analysis of Randomized Clinical Trials
Authors: Avash Das, Bhaskar Roy, Subhajit Dasgupta, Yan Gong, Urvi A Shah, Richard K Cheng, Michael G Fradley, Avirup Guha
Journal: Circulation (2021)

Introduction: Combination therapy of Immunomodulatory drugs (iMiDs) (Thalidomide, Lenalidomide, Pomalidomide) and Proteasome Inhibitors (PIs) (Bortezomib, Carfilzomib, Ixazomib) constitutes the backbone of treatment in MM patients. Cardiotoxic side-effect profile of iMiDs is not well-documented. Although Carfilzomib has been associated with cardiotoxicity, whether its adverse effects also mirror the class-specific cardiotoxic profile of PI remain obscure. Proper assessment of cardiotoxicity due to treatment reagents is necessary for optimal patient management. In this pairwise meta-analysis, we explored direct cardiotoxicity with iMiDs and PIs use in patients with multiple myeloma (MM). Hypothesis: Treatment with iMiDs and PIs in MM patients leads to independent cardiotoxicity that is associated with individual class of drugs. Methods: Published randomized control trials (RCTs) were searched up to May 2021 reporting cardiotoxicity (cumulative reported events of ischemia, arrhythmia, failure, stenosis) in MM patients (newly diagnoses and/or relapsed) treated with iMiD and/or PI. Studies, where iMiD or PI were used atop the chemotherapy vs placebo or no additional drugs (control) in the other arm, were included. The primary outcome was presence of cardiotoxicity after follow-up. Meta-analysis was performed using frequentist’s approach to estimate odds ratio (OR). Results: Eighteen RCTs including 8,479 MM patients were included in this analysis. Eleven studies compared iMiDs and seven studies compared PIs with control. CTACE high-grade (≥ grade 3) cardiotoxic events were increased with iMiDs in comparison to their control counterpart (OR 2.05; 95% CI 1.30-3.26). Cardiotoxicity was also noted more frequently with PI use when compared to the control group (OR 1.47; 95% CI 1.19-1.82). Similar difference was observed between high-grade cardiotoxic complication between these groups. There was no evidence of publication bias among studies. Conclusions: Our results showed iMiDs and PIs are independently associated with cardiotoxicity, which may warrant increased awareness among treating physicians and close monitoring of patients. The adverse cardiac event profile with these drugs require further investigation in future studies.
The Efficacy and Safety of Caplacizumab in Japanese Patients with Immune-Mediated Thrombotic Thrombocytopenic Purpura (iTTP): An Open-Label, Phase 2/3 Study
Authors: Yoshitaka Miyakawa, Kazunori Imada, Satoshi Ichikawa, Hitoji Uchiyama, Yasunori Ueda, Akihito Yonezawa, Shigeki Fujitani, Hiroshi Handa, Tadashi Matsushita, Hidesaku Asakura, Kenji Nishio, Kodai Suzuki, Yasuhiro Hashimoto, Shinobu Ohshima, Sayaka Tahara, Tomoyuki Tanaka, Masanori Matsumoto
Journal: Blood (2021)
Diverse Mechanisms of Resistance to Decitabine and Venetoclax Therapy in Newly Diagnosed and Relapsed/Refractory AML Inferred By Transcriptome Analysis
Authors: Kotoko Yamatani, Yoko Tabe, Abhishek Maiti, Tomohiko Ai, Kaori Saito, Kazuhiro R Nitta, Sonoko Kinjo, Kazuho Ikeo, Takashi Miida, Courtney D. DiNardo, Xiaoping Su, Marina Konopleva
Journal: Blood (2021)
Treatment Initiation of Venetoclax in Combination with Azacitidine or Decitabine in an Outpatient Setting in Patients with Untreated Acute Myeloid Leukemia
Authors: Sudhir Manda, Bertrand Anz, Christopher Benton, E. Randolph Broun, Habte Yimer, John Renshaw, George F. Geils, Jose Cruz, Suzanne Fanning, Jason Melear, Jeff P. Sharman, Kingston Kang, Anders Svensson, Madhavi Pai, William Donnellan
Journal: Blood (2021)
Lesion Dissemination in Baseline PET/CT (D-MAX) and IPS Score Predict ABVD Treatment Outcome in PET-2 Negative Advanced-Stage Hodgkin Lymphoma Patients Enrolled in the Prospective GITIL/FIL HD0607 Trial
Authors: Andrea Gallamini, Alessandro Rambaldi, Caterina Patti, Alessandra Romano, Simonetta Viviani, Bolis Silvia, Oppi Silvia, Livio Trentin, Maria Cantonetti, Sorasio Roberto, Gavarotti Paolo, Daniela Gottardi, Schiavotto Corrado, Battistini Roberta, Guido Gini, Ferreri Andres, Pavoni Chiara, Bergesio Fabrizio, Guerra Luca, Stephane Chauvie
Journal: Blood (2021)
Post-Transplantation Cyclophosphamide for Gvhd Prophylaxis in Related and Unrelated Allogeneic Hematopoietic Cell Transplantation: Study from the SFGM-TC Registry
Authors: Mauricette Michallet, Tereza Coman, Stephane Morisset, Mohamad Sobh, Raynier Devillier, Ibrahim Yakoub-Agha, Edouard Forcade, Johan A. Maertens, Jean-Henri Bourhis, Xavier Poiré, Hélène Labussière, Patrice Chevallier, Yves Chalandon, Nathalie Fegueux, Anne Huynh, Remy Dulery, Stéphanie Nguyen Quoc, Jean-Hugues Dalle, Claude-Eric Bulabois, Jean-Baptiste Mear, Marie-Thérèse Rubio, Nicole Raus, Marie Robin
Journal: Blood (2021)
Abstract 8996: Efficacy and Safety of Direct Oral Anticoagulants in Those Identifying as Black or African-American: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Authors: Max W Klein, Travis Skipina, Sam Schulman, Martin Gebel, Adam Budzikowski
Journal: Circulation (2021)

Introduction: Direct oral anticoagulants (DOACs) are indicated for prevention of stroke in non-valvular atrial fibrillation (AF) and for both treatment and prevention of recurrence of venous thromboembolism (VTE). Very little is known about efficacy and safety of these agents in patients identifying as Black or African-American (AA), as landmark trials demonstrating their non-inferiority to vitamin K antagonists (VKAs) are notable for discrepancies in enrollment by patient’s race. As the primary efficacy and safety outcomes for both AF and VTE are similar, we hypothesized that the cumulative efficacy and safety of DOACs in AA patients would be similar to that of the general population. Methods: A systematic review was conducted of clinical trials that investigated the comparison between DOACs and VKAs in patients for both AF and VTE. The Mantel-Haenszel Method was used to estimate pooled risk ratios (RRs) and corresponding confidence intervals (CIs) for the efficacy and safety of DOACs in AAs compared to the general population. Primary efficacy outcome was defined as stroke or systolic embolism in AF or symptomatic, recurrent VTE. Primary safety outcome was defined as major bleeding in both AF and VTE. Results: Nine studies were used for meta-analysis, with 26 eliminated due to lack of randomization or subgroup data for AAs. A total of 80,688 of patients were analyzed with 1.67% being AA. Regarding efficacy, the RR for AAs using DOACs compared to VKAs was 0.98 (95% CI 0.62,1.55; I 2 =0%; p=0.94), while the RR for the entire population was 0.90 (CI 0.78,1.04; I 2 =41%; p=0.1). Regarding safety, the RR for AAs using DOACs compared to VKAs was 0.83 (CI 0.56,1.25; I 2 =0%; p=0.92), while the RR for the entire population was 0.78 (CI 0.65,0.93; I 2 =76%; p&lt;0.01). Conclusions: The use of DOACs versus VKAs in AF and VTE for AAs results in similar efficacy to the general population. DOACs are non-inferior to VKAs with respect to safety outcomes in AF and VTE for AAs. It is uncertain why superiority of safety outcomes seen in the general population are not seen in the AA population, and will require further studies.