tbuckley/cabot-search huggingface dataset:
Adult Tiger Man
Authors: Ayşegül Aksu, Cihan Şin, Burçak Yilmaz
Journal: Clinical Nuclear Medicine (2022)

The scan demonstrated multiple linear and patchy hypermetabolic lesions in skeletal muscles, mimicking the coat of a tiger, and was referred to as "a tiger man" sign. A 38-year-old man was admitted to our hospital with weakness, shortness of breath, and muscle pain. A CT scan showed a mass in the anterior mediastinum. 18F-FDG PET/CT was performed to evaluate the mass with a preliminary diagnosis of thymoma; heterogeneous 18F-FDG uptake in the mediastinal mass and tiger man findings in skeletal muscles were observed in PET/CT images.
IMPLICATIONS OF POPULATION-BASED RECALIBRATION OF THE FRAMINGHAM RISK SCORE AND POOLED COHORT EQUATIONS IN ONTARIO, CANADA
Authors: Maneesh Sud, Atul Sivaswamy, Anna Chu, Peter Austin, Todd Anderson, Michael E. Farkouh, Douglas Lee, David Naimark, Idan Roifman, George Thanassoulis, Karen Tu, Jay Udell, Harindra Wijeysundera, Dennis T. Ko
Journal: Journal of the American College of Cardiology (2022)
Trends in Grade 5 Toxicity and Response in Phase I Trials in Hematologic Malignancy: 20-Year Experience From the Cancer Therapy Evaluation Program at the National Cancer Institute
Authors: Dai Chihara, Erich P. Huang, Shanda R. Finnigan, Lisa M. Cordes, Nebojsa Skorupan, Yoko Fukuda, Larry V. Rubinstein, S. Percy Ivy, James H. Doroshow, Loretta J. Nastoupil, Christopher R. Flowers, Naoko Takebe
Journal: Journal of Clinical Oncology (2022)

PURPOSE Cancer drug development has largely shifted from cytotoxic chemotherapy to targeted treatment in the past two decades. Although previous studies have highlighted improvement in response rates in recent phase I trials, disease-focused reporting is limited. METHODS We integrated patient-level data for patients with hematologic malignancies who participated in phase I trials sponsored by the National Cancer Institute Cancer Therapy Evaluation Program between January 2000 and May 2019 and estimated the trend of grade 5 toxicity and response by disease subtype over time. RESULTS We analyzed 161 trials involving 3,308 patients, all of whom were assessed for toxicity and 2,404 of whom were evaluable for response to therapy. The overall rate of grade 5 toxicities was 1.81% (95% CI, 1.36 to 2.27), with no significant change in the rate over time. Baseline characteristics associated with higher risk of grade 5 toxicity were age and performance status ≥ 2 at enrollment. Overall response rate (ORR) and complete response (CR) rate for all trials during the study period were 25.1% and 14.7%, respectively. A significant increase in both ORR and CR rate was observed over time (ORR, 18.5% in 2000-2005, 25.9% in 2006-2012, and 50.6% in 2013-2019, P &lt; .001). ORR in phase I trials varied across disease subtypes: 20.2% in acute myeloid leukemia, 9.1% in myelodysplastic syndrome, 43.2% in lymphoma, 42.9% in chronic lymphocytic leukemia, 15.1% in acute lymphoblastic leukemia, and 16.5% in myeloma. CONCLUSION Over time, the ORR and CR rates in phase I trials for hematologic malignancy have improved meaningfully, whereas the rate of toxicity-related death remains stable. This study provides broad experience that physicians can use when discussing the potential outcomes for patients with hematologic malignancy considering participation in phase I trials.
MYOCARDIAL IMPACT OF CLONAL HEMATOPOIESIS OF INDETERMINATE POTENTIAL (CHIP) SECRETOMES IN CARDIO-ONCOLOGY PATIENTS
Authors: Jennifer Kwan, Jennifer Vanoudenhove, Saiti Halder, Giulia Biancon, Kanika Jain, Raja Chakraborty, Maryam Lustberg, Lajos Pusztai, Stuart Campbell, Hongyu Zhao, Stephanie Halene, John Hwa
Journal: Journal of the American College of Cardiology (2022)
SELF-EXPANDING TRANSCATHETER AORTIC VALVE REPLACEMENT IN PATIENTS WITH EXTREMELY HORIZONTAL AORTA
Authors: Dao Zhou, Xianbao Liu, Jun Chen, Jiaqi Fan, Abuduwufuer Yidilisi, Hanyi Dai, Yeming Xu, Gangjie Zhu, Yuchao Guo, Jian’an Wang
Journal: Journal of the American College of Cardiology (2022)
SARS-CoV-2 infection among educational staff in Berlin, Germany, June to December 2020
Authors: Sophia Kindzierski, Welmoed van Loon, Stefanie Theuring, Franziska Hommes, Eberhard Thombansen, Malik Böttcher, Harald Matthes, Heike Rössig, David Weiger, Christof Wiesmann, Tobias Kurth, Valerie Kirchberger, Joachim Seybold, Frank P Mockenhaupt, Maximilian Gertler
Journal: Eurosurveillance (2022)

BackgroundSARS-CoV-2 infections in preschool and school settings potentially bear occupational risks to educational staff.AimWe aimed to assess the prevalence of SARS-CoV-2 infection in teachers and preschool educators and at identifying factors associated with infection.MethodsWe analysed cross-sectional data derived from 17,448 voluntary, PCR-based screening tests of asymptomatic educational staff in Berlin, Germany, between June and December 2020 using descriptive statistics and a logistic regression model.ResultsParticipants were largely female (73.0%), and median age was 41 years (range: 18-78). Overall, SARS-CoV-2 infection proportion was 1.2% (95% CI: 1.0-1.4). Proportion of positive tests in educational staff largely followed community incidence until the start of the second pandemic wave, when an unsteady plateau was reached. Then, the proportion of positive tests in a (concurrent) population survey was 0.9% (95% CI: 0.6-1.4), 1.2% (95% CI: 0.8-1.8) in teachers and 2.6% (95% CI: 1.6-4.0) in preschool educators. Compared with teachers, increased odds of infection were conferred by being a preschool educator (adjusted odds ratio (aOR): 1.6; 95% CI: 1.3-2.0) and by contact with a SARS-CoV-2 infected individual outside of work (aOR: 3.0; 95% CI: 1.5-5.5). In a step-wise backward selection, the best set of associated factors with SARS-CoV-2 infection involved age, occupation, and calendar week.ConclusionsThese results indicate that preschool educators bear increased odds of SARS-CoV-2 infection compared with teachers. At the same time, the private environment appeared to be a relevant source of SARS-CoV-2 infection for educational staff in 2020.
UNMASKING OF CONSTRICTIVE PERICARDITIS VENTRICULAR INTERDEPENDENCE AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Ahmad Mustafa, Sherif Elhosseiny, Thinzar Shwe, Craig Basman, Arber Kodra, Gregory Maniatis, Chad Kliger, James Lafferty
Journal: Journal of the American College of Cardiology (2022)
The crisis from above: Gatekeepers need better standards
Authors: Sarah R Schiavone, Julia G Bottesini, Simine Vazire
Journal: Behavioral and Brain Sciences (2022)

Abstract Improvements to the validity of psychological science depend upon more than the actions of individual researchers. Editors, journals, and publishers wield considerable power in shaping the incentives that have ushered in the generalizability crisis. These gatekeepers must raise their standards to ensure authors' claims are supported by evidence. Unless gatekeepers change, changes made by individual scientists will not be sustainable.
Phages and their satellites encode hotspots of antiviral systems
Authors: François Rousset, Florence Depardieu, Solange Miele, Julien Dowding, Anne-Laure Laval, Erica Lieberman, Daniel Garry, Eduardo P.C. Rocha, Aude Bernheim, David Bikard
Journal: Cell Host & Microbe (2022)

Bacteria carry diverse genetic systems to defend against viral infection, some of which are found within prophages where they inhibit competing viruses. Phage satellites pose additional pressures on phages by hijacking key viral elements to their own benefit. Here, we show that E. coli P2-like phages and their parasitic P4-like satellites carry hotspots of genetic variation containing reservoirs of anti-phage systems. We validate the activity of diverse systems and describe PARIS, an abortive infection system triggered by a phage-encoded anti-restriction protein. Antiviral hotspots participate in inter-viral competition and shape dynamics between the bacterial host, P2-like phages, and P4-like satellites. Notably, the anti-phage activity of satellites can benefit the helper phage during competition with virulent phages, turning a parasitic relationship into a mutualistic one. Anti-phage hotspots are present across distant species and constitute a substantial source of systems that participate in the competition between mobile genetic elements.
Endothelial Senescence: A New Age in Pulmonary Hypertension
Authors: Miranda K. Culley, Stephen Y. Chan
Journal: Circulation Research (2022)

Pulmonary hypertension is an enigmatic, deleterious disease driven by multiple heterogeneous causes with a burgeoning proportion of older patients with complex, chronic comorbidities without adequate treatment options. The underlying endothelial pathophenotypes that direct vasoconstriction and panvascular remodeling remain both controversial and incompletely defined. This review discusses emerging concepts centered on endothelial senescence in pulmonary vascular disease. This principle proposes a more heterogeneous, dynamic pulmonary endothelium in disease; it provides a potentially unifying feature of endothelial dysfunction in pulmonary hypertension irrespective of cause; and it supports a clinically relevant link between aging and pulmonary hypertension like other chronic illnesses. Thus, taking cues from studies on aging and age-related diseases, we present possible opportunities and barriers to diagnostic and therapeutic targeting of senescence in pulmonary hypertension.
Photothermal/NO combination therapy from plasmonic hybrid nanotherapeutics against breast cancer
Authors: Reesha Kakkadavath Vayalakkara, Chun-Liang Lo, Hsin-Hung Chen, Ming-Yin Shen, Ying-Chieh Yang, Arjun Sabu, Yu-Feng Huang, Hsin-Cheng Chiu
Journal: Journal of Controlled Release (2022)
National, regional, and global causes of mortality in 5–19-year-olds from 2000 to 2019: a systematic analysis
Authors: Li Liu, Francisco Villavicencio, Diana Yeung, Jamie Perin, Gerard Lopez, Kathleen L Strong, Robert E Black
Journal: The Lancet Global Health (2022)

Investments in the survival of older children and adolescents (aged 5-19 years) bring triple dividends for now, their future, and the next generation. However, 1·5 million deaths occurred in this age group globally in 2019, nearly all from preventable causes. To better focus the attention of the global community on improving survival of children and adolescents and to guide effective policy and programmes, sound and timely cause of death data are crucial, but often scarce.
MULTI-VESSEL PCI AND CABG DEMONSTRATE SIGNIFICANT IMPROVEMENTS IN POST-PROCEDURE GLOBAL LONGITUDINAL STRAIN AND LEFT VENTRICULAR EJECTION FRACTION
Authors: Rashmi Jain, Matthew T. Finn, Nadira Hamid, Rebecca T. Hahn, Jeffrey Wessler, Mark Lebehn, Lee Jin Hyun, Megha Prasad, Amirali Masoumi, Yousif Ahmad, Martin B. Leon, Dimitrios I. Karmpaliotis, Ajay J. Kirtane, Jeffrey W. Moses
Journal: Journal of the American College of Cardiology (2022)
META-ANALYSIS OF OUTCOMES OF TRANSRADIAL VERSUS TRANSFEMORAL ACCESS IN PATIENTS WITH PRIOR CORONARY ARTERY BYPASS GRAFT SURGERY UNDERGOING CORONARY ANGIOGRAPHY AND/OR PERCUTANEOUS CORONARY INTERVENTION
Authors: Noman Lateef, Azka Latif, Muhammad J. Ahsan, Waiel Abusnina, Kristen Brown, Mohsin Mirza, Mamas A. Mamas, Deepak L. Bhatt, Poonam Velagapudi
Journal: Journal of the American College of Cardiology (2022)
MORTALITY TRENDS IN HEART FAILURE AND DIFFERENCES BY RACE AND SEX IN THE UNITED STATES: 1999 - 2019
Authors: Amandeep Goyal, Shubham Lahan, Poonam Bhyan, Sagar Ranka, Suveenkrishna Pothuru, Harsh Mehta, Tarun Dalia, Neelkumar Patel, Prakash Acharya, Tai Thien Tan Tri Truyen, Haitham Mazek, Phillip Tran
Journal: Journal of the American College of Cardiology (2022)
NEUTROPHIL EXTRACELLULAR TRAPS (NETS) AND THROMBOLYSIS RESISTANCE - COMPARATIVE ANALYSIS OF THROMBOTIC/EMBOLIC SPECIMENS, RETRIEVED FROM CEREBRAL ARTERIES AFTER MECHANICAL THROMBECTOMY AND CORONARY ARTERY THROMBUS ASPIRATION IN MYOCARDIAL INFARCTION
Authors: Luca Mengozzi, Petr Widimsky, Annalisa Angelini, Ilaria Barison, Martin Augustin Maly, Marny Fedrigo, Giulia Lorenzoni, Dario Gregori, Lea Anna Cozzucoli, Radoslav Matej
Journal: Journal of the American College of Cardiology (2022)
VASCULAR ENDOTHELIAL GROWTH FACTOR IS ASSOCIATED WITH SEVERE COVID-19 DISEASE
Authors: Juan Solorzano, Keerthish Jaisingh, Javaria Ahmad, Sindhu Thevuthasan, Addison Foster, Megan Watts, Gopi K. Kolluru, A. Wayne Orr, Christopher G. Kevil, Paari Dominic
Journal: Journal of the American College of Cardiology (2022)
Cardiovascular Risk Prediction Scores in CKD: What Are We Missing?
Authors: Qandeel H. Soomro, David M. Charytan
Journal: Journal of the American Society of Nephrology (2022)

The burden of atherosclerotic cardiovascular disease (ASCVD) is high in CKD, with varied but linked manifestations, including coronary heart disease, cerebrovascular disease, and peripheral arterial disease. ASCVD in CKD is a complex interplay of inflammation, oxidative stress, and endothelial
Telemedicine management of systemic therapy with isotretinoin of patients with moderate-to-severe acne during the COVID-19 pandemic: A longitudinal prospective feasibility study
Authors: David Moreno-Ramírez, Miguel A. Duarte-Ferreras, Teresa Ojeda-Vila, Irene García-Morales, Maria D. Conejo-Mir, Almudena Fernández-Orland, Ana I. Sánchez-del-Campo, Noemí Eiris, Ana M. Carrizosa, Andrés Ruiz-de-Casas, Jose M. de-la-Torre, Juan M. Herrerías-Esteban, Lara Ferrándiz
Journal: Journal of the American Academy of Dermatology (2022)
SIX MONTH RESULTS FROM FIRST IN HUMAN CLINICAL EXPERIENCE OF A NO-IMPLANT INTERATRIAL SHUNT FOR HEART FAILURE WITH PRESERVED EJECTION FRACTION
Authors: James E. Udelson, Colin M. Barker, Christopher Meduri, Peter S. Fail, Darrell Solet, Jacob Kriegel, Tamaz Shaburishvili
Journal: Journal of the American College of Cardiology (2022)
Age-Varying Susceptibility to the Delta Variant (B.1.617.2) of SARS-CoV-2
Authors: June Young Chun, Hwichang Jeong, Yongdai Kim
Journal: JAMA Network Open (2022)

The Delta variant (B.1.617.2) is estimated to be more transmissible than previous strains of SARS-CoV-2, especially among children and adolescents. However, to our knowledge, there are no reports confirming this to date.
CLINICAL OUTCOME OF REVASCULARIZATION DEGREE WITH PERCUTANEOUS CORONARY INTERVENTION (PCI) PRIOR TO TRANSCATHETER AORTIC VALVE REPLACEMENT (TAVR): A COMPREHENSIVE META-ANALYSIS
Authors: Fares H. Ghanem, Ahmed Altibi, Omar Al-Taweel, Manar H. Jbara, Mohammad Alshami, Hind Rahmouni
Journal: Journal of the American College of Cardiology (2022)
IOXAGLATE VERSUS IODIXANOL IN THE PREVENTION OF CONTRAST-INDUCED NEPHROPATHY: RANDOMIZED IDPC TRIAL
Authors: Rafaela Andrade Penalva Freitas, Luiz Fernando Tanajura, Barbara Valente, Marinella P. Centemero, Daniel Chamie, Fausto Feres, Amanda G M R Souza, José de Ribamar Costa
Journal: Journal of the American College of Cardiology (2022)
Clinical Guideline Synopsis of Evaluation and Management of Well-Appearing Febrile Infants Aged 8 to 60 Days
Authors: Eileen Murtagh Kurowski, Seema Bhatt, Scott Reeves
Journal: JAMA Pediatrics (2022)

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THYROID STORM FROM GRAVES’ DISEASE ASSOCIATED WITH SEVERE PULMONARY HYPERTENSION AFTER PULMONARY THROMBOENDARTERECTOMY FOR CTEPH
Authors: Evan Carabelli, Philip Lavenburg, Riyaz Bashir, Paul Forfia, William Auger, Vladimir Lakhter, Frances A. Rogers, Lori Warren, Estefania Oliveros Soles, Anjali Vaidya
Journal: Journal of the American College of Cardiology (2022)
Safety and Efficacy of a Third Dose of BNT162b2 Covid-19 Vaccine
Authors: Edson D Moreira, Nicholas Kitchin, Xia Xu, Samuel S Dychter, Stephen Lockhart, Alejandra Gurtman, John L Perez, Cristiano Zerbini, Michael E Dever, Timothy W Jennings, Donald M Brandon, Kevin D Cannon, Michael J Koren, Douglas S Denham, Mezgebe Berhe, David Fitz-Patrick, Laura L Hammitt, Nicola P Klein, Haylene Nell, Georgina Keep, Xingbin Wang, Kenneth Koury, Kena A Swanson, David Cooper, Claire Lu, Özlem Türeci, Eleni Lagkadinou, Dina B Tresnan, Philip R Dormitzer, Uğur Şahin, William C Gruber, Kathrin U Jansen
Journal: New England Journal of Medicine (2022)

Active immunization with the BNT162b2 vaccine (Pfizer–BioNTech) has been a critical mitigation tool against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the coronavirus disease 2019 (Covid-19) pandemic. In light of reports of waning protection occurring 6 months after the primary two-dose vaccine series, data are needed on the safety and efficacy of offering a third (booster) dose in persons 16 years of age or older.
Stress Hyperglycemia Is Associated With an Increased Risk of Subsequent Development of Diabetes Among Bacteremic and Nonbacteremic Patients
Authors: Xiansong Wang, Frankie T.F. Cheng, Thomas Y.T. Lam, Yingzhi Liu, Dan Huang, Xiaodong Liu, Huarong Chen, Lin Zhang, Yusuf Ali, Maggie H.T. Wang, Jun Yu, Tony Gin, Matthew T.V. Chan, William K.K. Wu, Sunny H. Wong
Journal: Diabetes Care (2022)

OBJECTIVE Stress hyperglycemia is associated with an increased risk of diabetes among survivors of critical illness. We investigated whether patients without diabetes hospitalized for bacteremia or nonbacteremic diseases with transient stress hyperglycemia would have a higher risk of subsequent diabetes development compared with those who remained normoglycemic. RESEARCH DESIGN AND METHODS This retrospective observational study was conducted on 224,534 in-patients with blood culture records. Stress hyperglycemia was defined based on the highest random glucose level ≥7.8 mmol/L during the index admission period. Diagnosis of diabetes, as the primary end point of interest, was defined based on diagnostic codes, blood test results, or medication records. Differences in cumulative incidence and hazard ratios (HRs) of diabetes between groups were assessed using the Kaplan-Meier estimator and Cox regression. RESULTS After exclusion of patients with preexisting or undiagnosed diabetes or indeterminate diabetes status and propensity score matching, bacteremic patients with stress hyperglycemia had a significantly higher cumulative incidence of diabetes (HR 1.7, 95% CI 1.2–2.4) compared with those who remained normoglycemic. Stress hyperglycemia was further confirmed to be a diabetes predictor independent of age, sex, comorbidity, and other serological markers. For the nonbacteremic patients, stress hyperglycemia was similarly associated with a higher cumulative incidence of diabetes (HR 1.4, 95% CI 1.2–1.7). CONCLUSIONS Hospitalized patients with transient stress hyperglycemia had a higher risk of subsequent diabetes development compared with their normoglycemic counterparts. Recognition of an increased risk of diabetes in these patients can allow early detection and monitoring in their subsequent follow-ups.
GEOGRAPHIC DISTRIBUTION AND CLINICAL OUTCOMES AMONG PATIENTS WITH TRANSCATHETER MITRAL VALVE REPAIR IN THE UNITED STATES
Authors: Michael A. Fatuyi, Leanne Pereira, Vahid Namdarizandi, Awfa Zain Elabidin, Vivek Sharma, Leonid Khokhlov, Olukayode Ahmed Busari, Jeremiah Oluwadamisi, Asimul H. Ansari, Kamal Shemisa
Journal: Journal of the American College of Cardiology (2022)
PERCUTANEOUSLY MANAGED LIMA GRAFT FISTULIZING PULMONARY VEIN, CAUSING STEAL PHENOMENON FROM ANOMALOUS LATERAL THORACIC BRANCH
Authors: Akarsh Parekh, Vivek Sengupta, Zurla Zachary, Nitin Jain, Nithin R. Gottam
Journal: Journal of the American College of Cardiology (2022)
A comparison of the different questionnaires used to measure health‐related quality of life in patients with dermatological conditions
Journal: British Journal of Dermatology (2022)

Linked Article: Szabó et al. Br J Dermatol 2022; 186:485-495. Dermatology Life Quality Index (DLQI) and Skindex-16 are among the most commonly used questionnaires to measure health-related quality of life in patients with dermatological conditions. DLQI has an alternative version with different scoring named DLQI-R. In order to understand the differences in the three measures better we compared how accurately these questionnaires can measure health-related quality of life. We surveyed 618 patients with self-reported physician-diagnosed dermatological conditions in Hungary. The most common diagnoses were warts (23%), eczema (23%), onychomycosis (18%), acne (13%) and psoriasis (13%). The most interesting finding in the study was that 64% of patients that reported no problems with their health-related quality of life using DLQI or DLQI-R, reported problems using Skindex-16. The authors found that Skindex-16 and DLQI-R outperformed the DLQI in the majority of measurement properties. In patients with mild symptoms, DLQI and DLQI-R might not be able to capture small impairments in health-related quality of life, and therefore, Skindex-16 seems more suitable in this population. The results suggest that the higher number of response options and their 'frequency' format in the Skindex-16 questions seem more useful to report problems in patients' lives than the fewer 'severity' format categories of the DLQI (how often you experience problems versus how severe they are). This study helps physicians and researchers in deciding which questionnaire to use in daily practice and also for research purposes.
Monoclonal proteinuria predicts progression risk in asymptomatic multiple myeloma with a free light chain ratio ≥100
Authors: Alissa Visram, S. Vincent Rajkumar, Prashant Kapoor, Angela Dispenzieri, Martha Q. Lacy, Morie A. Gertz, Francis K. Buadi, Suzanne R. Hayman, David Dingli, Taxiarchis Kourelis, Wilson Gonsalves, Rahma Warsame, Eli Muchtar, Nelson Leung, Robert A. Kyle, Shaji K. Kumar
Journal: Leukemia (2022)
Cysteinyl leukotrienes and acetylcholine are biliary tuft cell cotransmitters
Authors: Maryam Keshavarz, Schayan Faraj Tabrizi, Anna-Lena Ruppert, Uwe Pfeil, Yannick Schreiber, Jochen Klein, Isabell Brandenburger, Günter Lochnit, Sudhanshu Bhushan, Alexander Perniss, Klaus Deckmann, Petra Hartmann, Mirjam Meiners, Petra Mermer, Amir Rafiq, Sarah Winterberg, Tamara Papadakis, Dominique Thomas, Carlo Angioni, Johannes Oberwinkler, Vladimir Chubanov, Thomas Gudermann, Ulrich Gärtner, Stefan Offermanns, Burkhard Schütz, Wolfgang Kummer
Journal: Science Immunology (2022)

The gallbladder stores bile between meals and empties into the duodenum upon demand and is thereby exposed to the intestinal microbiome. This exposure raises the need for antimicrobial factors, among them, mucins produced by cholangiocytes, the dominant epithelial cell type in the gallbladder. The role of the much less frequent biliary tuft cells is still unknown. We here show that propionate, a major metabolite of intestinal bacteria, activates tuft cells via the short-chain free fatty acid receptor 2 and downstream signaling involving the cation channel transient receptor potential cation channel subfamily M member 5. This results in corelease of acetylcholine and cysteinyl leukotrienes from tuft cells and evokes synergistic paracrine effects upon the epithelium and the gallbladder smooth muscle, respectively. Acetylcholine triggers mucin release from cholangiocytes, an epithelial defense mechanism, through the muscarinic acetylcholine receptor M3. Cysteinyl leukotrienes cause gallbladder contraction through their cognate receptor CysLTR1, prompting emptying and closing. Our results establish gallbladder tuft cells as sensors of the microbial metabolite propionate, initiating dichotomous innate defense mechanisms through simultaneous release of acetylcholine and cysteinyl leukotrienes.
Even Mild COVID-19 May Change the Brain
Authors: Jennifer Abbasi
Journal: JAMA (2022)

Yu-Hui Liu, MD, PhD; Yang Chen, MD; Qing-Hua Wang, MD, PhD; Ling-Ru Wang, BN; Li Jiang, BN; Ying Yang, BN; Xian Chen, BN; Ying Li, BN; Yuan Cen, BN; Cheng Xu, MD, PhD; Jie Zhu, MD, PhD; Wei Li, MD, PhD; Ye-Ran Wang, MD; Li-Li Zhang, MD, PhD; Juan Liu, MD, PhD; Zhi-Qiang Xu, MD, PhD; Yan-Jiang Wang, MD, PhD
PERI-PROCEDURAL COMPLICATIONS ASSOCIATED WITH TRANSCATHETER AORTIC VALVE REPLACEMENT IN PATIENTS WITH DEMENTIA
Authors: Rezwan F. Munshi, Sarath Lal Mannumbeth Renjithlal, Viqarunnisa Zahid, Nisha U. Pillai, Ofek Hai, Amgad N. Makaryus
Journal: Journal of the American College of Cardiology (2022)