tbuckley/cabot-search huggingface dataset:
Associations between Statin use and changes in pain, function and structural progression: a longitudinal study of persons with knee osteoarthritis
Authors: Daniel L Riddle, George Moxley, Levent Dumenci
Journal: Annals of the Rheumatic Diseases (2012)

Recently published research suggests that statins may have beneficial structural effects in persons with knee osteoarthritis (OA). The potential effects of statins on patient-reported knee pain and function have not been examined. We studied a large prospective community-based cohort of persons with knee OA to determine if statin usage was associated with changes in knee structure, pain and function trajectories.Data were obtained from the Osteoarthritis Initiative using a subset of 2207 persons with radiographically suspected or confirmed knee OA. The changes in Western Ontario and McMaster Universities Arthritis Index (WOMAC) Pain and Physical Function scores, pain intensity and Kellgren-Lawrence radiographic grade over 4 years were examined. Data from persons were coded based on whether they were incident users of statins over the 4-year period. Outcome trajectories and probability of statin use were examined over the 4-year study period using parallel processing growth curve modelling. The analysis adjusted for potential confounders and determined if statin use predicted outcome trajectories.Statin users accounted for 6.7% of the sample in year 1 and 16.4% in year 4. Statin use was not associated with improvements in knee pain, function or structural progression trajectories. The only significant finding indicated that increased duration of statin use was associated with worsening in WOMAC Physical Function scores over the study period (β=0.161, p=0.005).Statin use was not associated with improvements in knee pain, function or structural progression over the 4-year study period.
Oral prostaglandin E2 in ductus-dependent pulmonary circulation.
Authors: E DSilove, J YCoe, M FShiu, J DBrunt, A JPage, S PSingh, M DMitchell
Journal: Circulation (1981)

Prostaglandin E2 (PGE2) was administered orally, in doses of 12-65 microgram/kg at intervals of 1-4 hours, to 12 neonates in whom the pulmonary circulation depended on patency of the ductus arteriosus. After an oral dose, both oxygen saturation (SaO2) and plasma PGE2 concentration increased consistently within 15-30 minutes, reaching values comparable to those during i.v. infusions. Treatment continued for 5 days to 4 months. In eight infants, PGE2 withdrawal resulted in a decrease of SaO2, from a mean of 75 +/- 7% to 57 +/- 10% (+/- SD). The ductus remained responsive for long periods--in four infants, for over 3 months. Consequently, surgery could be delayed until the infants and their pulmonary arteries had grown. Side effects during oral therapy were similar to those during i.v. infusion but were less severe in this series. The effectiveness and simplicity of oral PGE2 administration have advantages over i.v. administration, especially for long-term treatment.
Carnitine transport in isolated adult rat heart myocytes and the effect of 7,8-diOH chlorpromazine.
Authors: JBahl, TNavin, A AManian, RBressler
Journal: Circulation Research (1981)

We studied the carnitine transport system in isolated adult rat heart myocytes able to tolerate physiological concentrations of calcium. Carnitine uptake occurred against a concentration gradient and was inhibited by 2,4-dinitrophenol (2,4-DNP). The transport system had a Km of 60 microM and a Vmax of 110 pmol/mg protein per hour. The carnitine precursor deoxycarnitine, acetylcarnitine, and both the D and L isomers were effective inhibitors of uptake. The transport of carnitine was not dependent on sodium ions, but was stimulated by decreasing concentrations of calcium ions. Decreased uptake was observed in the presence of beta-adrenergic agonists and antagonists, dibutyrl cyclic AMP, local anesthetics, and ouabain. No significant alteration of uptake was effected by atropine, carbachol or a variety of tricyclic agents. The auto-oxidation product of 7,8-dihydroxychlorpromazine (7,8-diOH CPZ) decreased carnitine efflux from myocytes, which were highly permeable to low molecular weight compounds. We found t...
Oxidized low density lipoproteins potentiate vasoconstrictions to various agonists by direct interaction with vascular smooth muscle.
Authors: JGalle, EBassenge, RBusse
Journal: Circulation Research (1990)

In hypercholesterolemia, low density lipoproteins (LDLs) may be oxidized by monocytes/macrophages in the arterial wall. Therefore, we investigated the effect of LDL and its oxidative derivatives (ox-LDL) on vascular tone in isolated perfused rabbit femoral arteries. Perfusion of endothelium-intact and endothelium-denuded segments with ox-LDL (80 micrograms protein/ml) caused no or only weak vasoconstrictions in the absence of contractile agonists. However, in the presence of ox-LDL, vasoconstrictions to threshold concentrations of norepinephrine, serotonin, phenylephrine, or potassium were significantly enhanced. This enhancement correlated with the degree of oxidation. When ox-LDL was administered at higher concentrations (greater than 200 micrograms protein/ml), it evoked moderate vasoconstrictions even in the absence of contractile agonists. Native LDL had no effect on vascular tone. Preincubation with verapamil, diltiazem, and nitrendipine inhibited vasoconstrictions evoked by ox-LDL, both in the pres...
The effect of concurrent oral administration of propranolol and disopyramide on cardiac function in healthy men.
Authors: W FCathcart-Rake, J ECoker, F LAtkins, D HHuffman, K MHassanein, D DShen, D LAzarnoff
Journal: Circulation (1980)

Sixteen healthy men were evaluated for left ventricular performance changes and beta-blockade after therapeutic oral doses of disopyramide and propranolol administered alone and concurrently. The volunteers were randomly assigned to receive one of two drug treatment regimens that differed in the sequence and duration of administration of the drugs. Left ventricular function was assessed by echocardiographically determined ejection fraction (EF) and systolic time intervals. Beta-blockade was assessed by changes in exercise heart rate. Both disopyramide and propranolol exhibited negative inotropic activity, as evidenced by significant, although clinically inconsequential, decreases in EF and increases in the ratio of preejection period to left ventricular ejection time. The negative inotropic effects of a single 200-mg dose of disopyramide and an 80-mg dose of propranolol were comparable, while chronic disopyramide therapy (200 mg every 6 hours for 1 week) had a greater negative inotropic effect than chroni...
Angiotensin II directly stimulates release of atrial natriuretic factor in isolated rabbit hearts.
Authors: AFocaccio, MVolpe, GAmbrosio, GLembo, SPannain, SRubattu, IEnea, SPignalosa, MChiariello
Journal: Circulation (1993)

BACKGROUNDPrevious studies have shown that infusion of angiotensin II (Ang II) increases plasma concentrations of atrial natriuretic factor (ANF) in vivo. This phenomenon has been considered secondary to the effects of Ang II on cardiac and systemic hemodynamics. The present study was designed to assess whether Ang II may exert a direct stimulatory effect on ANF release from the heart independent of changes in hemodynamics.METHODS AND RESULTSIsolated rabbit hearts were perfused in the Langendorff mode. Heart rate, coronary flow, and atrial and left ventricular (LV) volumes were kept constant. After stabilization, Ang II was infused intracoronary at increasing doses (10(-11) to 10(-8) M) in nine hearts and at a single dose of 10(-10) M in 10 hearts. Each infusion lasted for 5 minutes and was followed by a 10-minute washout period. Four hearts received vehicle alone for 80 minutes. Ang II induced a dose-dependent increase in coronary perfusion pressure and in LV developed pressure. ANF release, measured by ...
Comparison of M-mode and cross-sectional echocardiography in infective endocarditis.
Authors: L SWann, C CHallam, J CDillon, A EWeyman, HFeigenbaum
Journal: Circulation (1979)

Cross-sectional and M-mode echocardiograms were performed on 23 consecutive patients with infective endocarditis. Both M-mode and cross-sectional echocardiography identified vegetations in 18 patients, 10 of whom required valve replacement within 1 month of presentation. Cross-sectional echocardiography alone identified a vegetation in one patient with a prosthetic valve. Neither technique identified vegetations in five instances. The size and shape of a vegetation on cross-sectional echocardiography did not accurately predict the need for early valve replacement of the incidence of major peripheral emboli.
Angiotensin II-forming pathways in normal and failing human hearts.
Authors: HUrata, BHealy, R WStewart, F MBumpus, AHusain
Journal: Circulation Research (1990)

Reduced preload and afterload to the heart are important effects of angiotensin converting enzyme (ACE) inhibitors in the treatment of congestive heart failure. However, since angiotensin II (Ang II) directly increases the strength of myocardial contraction, suppression of Ang II formation by ACE inhibitors could potentially reduce the beneficial effects of Ang II on the failing heart. To study how ACE inhibition suppresses cardiac Ang II formation in man, we characterized ACE-dependent and ACE-independent Ang II-forming pathways in eight normal and 24 failing human hearts obtained at cardiac transplantation. Ang II-forming activity in left ventricular (LV) membrane preparations was assessed by measuring the conversion of [125I]angiotensin I (Ang I) to [125I]Ang II. LV [125I]Ang II-forming activity in normal hearts (35.5 +/- 2.7 fmol/min/mg, n = 8) was not different from that in hearts from patients with ischemic cardiomyopathy (25.5 +/- 2.9 fmol/min/mg, n = 9) and was 48% lower (p less than 0.001) in hea...
Predicting recovery of severe regional ventricular dysfunction. Comparison of resting scintigraphy with 201Tl and 99mTc-sestamibi.
Authors: J EUdelson, P SColeman, JMetherall, N GPandian, A RGomez, J LGriffith, N LShea, EOates, M AKonstam
Journal: Circulation (1994)

BACKGROUNDRegional 201Tl activity after resting injection, imaged early and after redistribution, reflects viable myocardium and can predict improved isotope uptake as well as regional and global ventricular function after revascularization. 99mTc-sestamibi, a perfusion tracer with favorable imaging characteristics, has distinct kinetics compared with 201Tl, demonstrating minimal redistribution; this property may give 201Tl an advantage for detecting viable myocardium, particularly in segments with resting hypoperfusion. The purpose of this study was to compare regional activities of 201Tl and 99mTc-sestamibi after resting injections in patients with coronary artery disease and regional or global left ventricular dysfunction and to assess their comparative abilities for predicting recovery of severe regional ventricular dysfunction after revascularization.METHODS AND RESULTSQualitative and quantitative comparisons of rest and redistribution 201Tl activity and sestamibi activity 1 hour after rest injection...
Resident Forum
Authors: Mark S. George
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Role of leukocytes in coronary vascular endothelial injury due to ischemia and reperfusion.
Authors: F MSheridan, I MDauber, I FMcMurtry, E JLesnefsky, L DHorwitz
Journal: Circulation Research (1991)

A possible cause of the coronary endothelial injury that occurs with ischemia and reperfusion is the local accumulation of leukocytes during these events. To investigate the role of leukocytes in coronary endothelial injury, we tested the effect of leukocyte removal by filtering on coronary endothelial function in a canine model of regional myocardial ischemia and reperfusion. Blood was supplied to the left anterior descending and circumflex arteries of anesthetized dogs via an extracorporeal circulation. A 60-minute left anterior descending occlusion was followed by 120 minutes of reperfusion either with (n = 6) or without (n = 6) leukocyte filters in the extracorporeal circuit. Regional myocardial blood flow was measured with radiolabeled microspheres. Radiolabeled autologous transferrin (113mIn) and erythrocytes (99mTc) were given intravenously during reperfusion for assessment of microvascular permeability. Left anterior descending and circumflex coronary artery rings were assessed in vitro for endoth...
Insurability of the adolescent and young adult with heart disease. Report from the Fifth Conference on Insurability, October 3-4, 1991, Columbus, Ohio.
Authors: H DAllen, W MGersony, K ATaubert
Journal: Circulation (1992)

By the mid-1990s there will be more than 500,000 young adults in the United States over the age of 21 with a cardiac malformation. Presently more than half of this population is denied insurance coverage entirely or in part because of their preexisting condition. Because some did not have coverage and because of uncertainty about whom to see for their cardiology care, patients assessed in NHS-II who were evaluated by their physician on an annual basis before the age of 21 were seen by a cardiologist only every 10 years after the age of 21. However, they have been shown by NHS-II to be well-educated, productive in the workplace, and to share an equal place in society with the general population. Their health-care costs are decidedly lower after the age of 21 than before. This group represents a microcosm of a general society of more than 37 million Americans who, for various reasons, are not insured. Dr. Wiener described an American health-care system in crisis. Smaller companies are no longer able to affo...
Myocardial infarct size-limiting effect of ischemic preconditioning was not attenuated by oxygen free-radical scavengers in the rabbit.
Authors: TIwamoto, TMiura, TAdachi, TNoto, TOgawa, ATsuchida, OIimura
Journal: Circulation (1991)

BACKGROUNDThe limiting effect of ischemic preconditioning on infarct size has been reported in canine hearts, which contain considerable amounts of xanthine oxidase, a free radical-producing enzyme. Furthermore, a recent study suggested that free radicals generated during preconditioning may contribute to the cardioprotective effect of preconditioning. The present study examined 1) whether preconditioning limits infarct size in rabbits, which, like humans, lack myocardial xanthine oxidase and 2) whether the cardioprotective effect of PC is mediated by free radicals.METHODS AND RESULTSA branch of the circumflex coronary artery in rabbits was occluded for 30 minutes and then reperfused for 72 hours. Myocardial infarct size and area at risk were determined by histology and fluorescent particles, respectively. Five groups were studied: an untreated control group, a preconditioned group (PC group), a high-dose superoxide dismutase (SOD)-treated preconditioned group (high-dose SOD-PC group), a low-dose SOD-trea...
Letter by Mansour et al Regarding Article, “Early Use of N-Acetylcysteine With Nitrate Therapy in Patients Undergoing Primary Percutaneous Coronary Intervention for ST-Segment–Elevation Myocardial Infarction Reduces Myocardial Infarct Size (the NACIAM Trial [ <i>N</i> -Acetylcysteine in Acute Myocardial Infarction])”
Authors: Alexandre Mansour, Hervé Le Breton, Vincent Auffret
Journal: Circulation (2018)
Cabazitaxel versus abiraterone or enzalutamide in poor prognosis metastatic castration-resistant prostate cancer: a multicentre, randomised, open-label, phase II trial
Authors: M. Annala, S. Fu, J.V.W. Bacon, J. Sipola, N. Iqbal, C. Ferrario, M. Ong, D. Wadhwa, S.J. Hotte, G. Lo, B. Tran, L.A. Wood, J.R. Gingerich, S.A. North, C.J. Pezaro, J.D. Ruether, S.S. Sridhar, H.M.L. Kallio, D.J. Khalaf, A. Wong, K. Beja, E. Schönlau, S. Taavitsainen, M. Nykter, G. Vandekerkhove, A.A. Azad, A.W. Wyatt, K.N. Chi
Journal: Annals of Oncology (2021)
More Young Adults Detected With 3+ Adenomas After Bowel Preparation with 1L Polyethylene Glycol Ner1006 Versus 2L Polyethylene Glycol or Oral Sulfate Solution
Authors: MA Álvarez-González, L Clayton
Journal: Endoscopy (2021)

Aims The prevalence of colorectal adenomas is age-dependent, with patients aged ≥60 years mostly affected. Young adults aged ≤50 years have recently been identified as potentially at increased risk of developing colorectal adenomas and colorectal cancer. Clinical guidelines recommend shorter surveillance periods for patients detected with three or more adenomas[ 1 ]. We analysed whether 1L polyethylene (PEG)-based NER1006 can allow endoscopists to detect more adenomas in young adults than 2LPEG/OSS.
A new method for evaluating antiarrhythmic drug efficacy.
Authors: MSami, HKraemer, D CHarrison, NHouston, CShimasaki, R FDeBusk
Journal: Circulation (1980)

To develop standards for distinguishing antiarrhythmic drug effect from spontaneous variability of premature ventricular complexes (PVCs), 21 males (mean age 56 +/- 8 years) with chronic ischemic heart disease and PVCs underwent symptom-limited treadmill exercise testing and 24-hour ambulatory monitoring before and after 2 weeks of placebo medication. Linear regression analysis was used to describe the relationship between baseline and placebo PVC frequency for various indexes of ventricular ectopic activity and to establish 95% and 99% one-tailed confidence intervals for this relationship within the group of 21 patients. The lower limit of baseline PVC frequency for which the procedure could distinguish a placebo from a true drug response, termed the  threshold, was an average frequency of 2.2 PVCs/hour for ambulatory electrocardiographic monitoring and 1.2 PVCs/min for treadmill exercise testing. All patients exceeded the sensitivity threshold on baseline ambulatory ECGs, but only 38% of pa...
Echocardiographic detection of tricuspid valve prolapse.
Authors: P NChandraratna, J MLopez, J JFernandez, L SCohen
Journal: Circulation (1975)

The echocardiographic findings in 12 patients with tricuspid valve prolapse are presented. Eight of these patients had associated mitral valve prolapse. Only one of the above patients had the characteristic physical signs of tricuspid incompetence. Two types of abnormality were noted on the echocardiogram of the tricuspid valve. In eight patients, the systolic segment of the tricuspid valve showed an initial horizontal motion followed by a posterior motion in midsystole. Four patients exhibited posterior motion of the tricuspid valve in early systole, which reached a maximum in midsystole, and this was followed by an anterior motion, thus producing a hammock-like configuration. We conclude that echocardiography is useful in the diagnosis of tricuspid valve prolapse. Since this condition may be associated with clinically significant tricuspid incompetence or bacterial endocarditis, its recognition is of clinical importance.
Echocardiographic assessment of the evolution of amyloid heart disease: a study with familial amyloid polyneuropathy.
Authors: MHongo, SIkeda
Journal: Circulation (1986)

To determine the evolution of amyloid heart disease, 28 patients with familial amyloid polyneuropathy (FAP) were studied by echocardiography. The incidence and degree of the abnormalities were correlated with the neurologic disabilities, duration of the illness, and age in cross-sectional studies. Serial studies were performed in 12 patients, who were followed for a mean of 27.7 months. At the initial examinations, left ventricular diastolic function was reduced in six patients, while systolic function was preserved in eight. On follow-up there occurred significant increases in ventricular septal wall thickness (from 10.7 +/- 3.1 to 13.1 +/- 3.2 mm; p less than .01) and posterior wall thickness (from 11.8 +/- 2.5 to 13.5 +/- 2.3 mm; p less than .01), and reductions in the E-F slope of the mitral valve (from 64.4 +/- 18.8 to 43.9 +/- 11.0 mm/sec; p less than .01), percent fractional shortening (from 36.5 +/- 9.4% to 28.8 +/- 8.2%; p less than .02), and left ventricular internal diastolic dimension (from 46...
EUS Guided Drainage Of Non-Walled Off Organised Pancreatic Necrosis; A Tertiary Center Experience
Authors: W Ahmed, A Caracostea, D Reffitt, A Prachalias, K Menon, P Srinivasan, ND Heaton, A Patel, PM Harrison, D Joshi, J Devlin
Journal: Endoscopy (2021)

Aims To describe the clinical outcomes in patients undergoing EUS guided pancreatic necrosectomy in non-walled off organised collections.
36P Cost-effectiveness of lung cancer screening with low-dose computed tomography in China: A modeling study
Authors: Y. Du, Y. Li, G. Sidorenkov, Z. Ye, R. Vliegenthart, M.A. Heuvelmans, M. Dorrius, H.J.M. Groen, S. Liu, L. Fan, M.J.W. Greuter, G.H. de Bock
Journal: Journal of Thoracic Oncology (2021)
A Protective Role of DNA Repair Genes Against Acute Graft Versus Host Disease in Children
Authors: Patricia Huezo-Diaz, Chakradhara RS Uppugunduri, Mohamed Aziz Rezgui, Anuj Tyagi, Vid Mlakar, Laurence Lesne, Tiago Nava, Yves Theoret, Yves Chalandon, Robbert Bredius, Jean-Hugues Dalle, Peter Bader, Christina Peters, Henrique Bittencourt, Maja Krajinovic, Marc Ansari
Journal: Blood (2017)
Interaction of adriamycin in vitro with cardiac myofibrillar proteins.
Authors: WLewis, JKleinerman, SPuszkin
Journal: Circulation Research (1982)

Binding of the anthracycline antibiotic doxorubicin [Adriamycin (ADR)] to selected cardiac muscle contractile proteins was determined in purified canine heart actin and alpha-actinin. Adriamycin binding to these proteins in solution was measured by equilibrium dialysis and gel filtration with [14C]-labeled ADR. Adriamycin did not bind when its primary amino group was blocked. Adriamycin binding did not affect actin polymerization as detected by viscometry. Viewed under the electron microscope, however, ADR promoted formation of distinct actin filaments in the presence of microM amounts of ATP without K+ and MG++. Adriamycin-induced actin microfilaments were thicker (120 A) than those of F-actin controls (70 A) and stimulated myosin-ATPase to higher levels than the F-actin controls. It appears that ADR has a direct effect on the biophysical and biochemical properties of heart myofibril proteins in vitro.
Plasmin-resistant PSD-95 inhibitors resolve effect-modifying drug-drug interactions between alteplase and nerinetide in acute stroke
Authors: Diana Mayor-Nunez, Zhanxin Ji, Xiujun Sun, Lucy Teves, J. David Garman, Michael Tymianski
Journal: Science Translational Medicine (2021)

The plasma stability and neuroprotective effectiveness of nerinetide are enhanced by partially substituting l - to d -amino acids.
Difficult Common Bile Duct Stones: What To Do?
Authors: wEl Ouardi, M Borahma, N Lagdali, I Benelbarhdadi, FZ Ajana
Journal: Endoscopy (2021)

Aims Endoscopic retrograde cholangiopancreatography (ERCP) is the treatment of choice of common bile duct (CBD) stones, providing a complete clearance of the CBD in more than 90 % of cases. However, the presence of difficult stones can limit its results. Our work aimed to evaluate different techniques for managing difficult CBD stones as well as their results.