tbuckley/cabot-search huggingface dataset:
Detection of kinase activity profiles of colon cancer predicts stage of disease and identifies potential molecular targets for therapy
Authors: Jurriaan B. Tuynman, Henry H. Versteeg, Helene H. Thygesen, Louis Vermeulen, Aeilko H. Zwinderman, Dirk J. Richel
Journal: Cancer Research (2005)

1255  INTRODUCTION: The main prognostic marker in colon carcinoma (CC) is nodal status at time of primary resection. However, staging of CC fails to accurately predict outcome of disease. Rapid technological advances in molecular biology and biochemistry peptide-array based techniques for the detection of kinase activity. Kinomic profiling is a promising new approach for cancer diagnostics and for target identification, since biological function and cellular metabolism resembles the phenotype of cancer rather than protein and gene expression. AIMS & METHODS: We hypothesized that kinomic profiling differentiates normal epithelial from CC and tumor from metastasis of 10 patients. Histological analysis of cryosections was performed to ensure the quality and specificity of frozen tissue specimens. A newly developed protein microarray containing 1200 peptides in duplo with specific phosphorylation sites (PepChip) was used for in vitro phosphorylation analysis with 33p-gamma-ATP. We optimized normalisation and used both variation coefficient dissimilarity measurements and SAM software to extract kinases that were significantly up- or down regulated. The same lysates were analyzed with western blot and in vitro kinase assays. RESULTS: Specific kinomic profiles of normal colon (10) versus colon cancer (10) and metastasis (10) were detected by the kinase array.The combined profiles were significantly different. We observed significantly enhanced activity of the kinases IGFr, PI3k, Akt, and PKC in tumor as compared to normal tissue. Interestingly distinct kinomic profiles marked metastatic lesions from primary tumor. In metastatic tumors EGFr and I-kappa-B related pathways were more active. The results were reproducible in independent experiments. Importantly, western blot analysis and in vitro kinase assays of the most significant kinases confirmed these findings. CONCLUSION: The kinase peptide substrate array is a powerful method to detect cellular metabolism profiles that distinguish normal colon, colon tumor tissue and colon metastasis. In addition, important kinases responsible for oncogenic behavior are elucidated which potentially provide targets for therapy. At the moment kinomic profiles of cc tissue of patients with CC are combined with clinical outcome data to extract clusters of active kinases and signal transduction pathways responsible for tumor recurrence and survival.
The Tumor Associated Antigen PRAME Exhibits Dualistic Functions That Are Targetable in Diffuse Large B-Cell Lymphoma
Authors: Katsuyoshi Takata, Lauren C. Chong, Daisuke Ennishi, Avinash Thakur, Shannon Healy, Elena Viganò, Tao Dao, Julie S Nielsen, Susana Ben-Neriah, Tomohiro Aoki, Ethan Tse, Stacy Hung, Michael Y. Li, Merrill Boyle, Sung Soo Mun, Christopher Bourne, Bruce W Woolcock, Adele Telenius, Allen Zhang, Ali Bashashati, Saeed Saberi, Gianluca D' Antonio, Brad H Nelson, Sohrab P Shah, Pamela Hoodless, Ari Melnick, Randy D. Gascoyne, Joseph M Connors, David A. Scheinberg, Wendy Béguelin, David W. Scott, Christian Steidl
Journal: Blood (2020)
Environmental Sars-Cov-2 Surface Testing: Low Incidence of Virus Positivity in Outpatient and Inpatient Hematology/Oncology Settings
Authors: Mansi R Shah, Imraan Jan, Jeremy Johns, Kuldip Singh, Pallavi Kumar, Norma Belarmino, Kara Saggiomo, Carolyn Hayes, Deborah Toppmeyer, Kimyatta Washington, Bruce Haffty, Steven Libutti, Andrew M. Evens
Journal: Blood (2020)
ZRSR1 Cooperates with ZRSR2 in Regulating Splicing of U12-Type Introns in Murine Hematopoietic Cells
Authors: Zeya Cao, Vikas Madan, Weoi Woon Teoh, Pushkar Dakle, Lin Han, Pavithra Shyamsunder, Siqin Zhou, Jia Li, Hazimah Binte Mohd Nordin, Shi Jizhong, Yu Shuizhou, Henry Yang, Md Zakir Hossain, Wee-Joo Chng, H. Phillip Koeffler
Journal: Blood (2020)
New horizons in trans and non-binary health care: Bridging identity affirmation with chronicity management in sexual and reproductive services
Authors: Nik M. Lampe, Alexandra C. H. Nowakowski
Journal: International Journal of Transgender Health (2020)

Background Transgender and non-binary people experience erasure, stigma, and discrimination in sexual and reproductive health care. Previous research shows worse sexual and reproductive health outcomes and higher rates of chronicity for trans and non-binary populations as compared to cisgender populations. Historically such outcomes have been framed as separate issues.Aims To describe methodological approaches for exploring gaps in the sexual and reproductive health care of transgender and non-binary people, and explore intersections between chronic disease management and gender-affirming care.Methods We critically reviewed methods for studying sexual and reproductive care and chronic condition management among trans and non-binary populations. We focus on two themes: unmet needs and response strategies.Results We summarize findings and opportunities in existing research about service needs in trans and non-binary care. Key barriers to effective sexual and reproductive care for trans and non-binary people include persistent medical myths about trans people and bodies, siloization of different domains of health and associated services, lack of research on how chronic disease treatments interact with transition related care, and lack of active communication between providers and patients about individual care needs and goals.Discussion We recommend methodologically diverse research with trans and non-binary populations capturing: (1) erasure, stigma, and discrimination in sexual and reproductive health care settings; (2) individual, interpersonal, and structural factors catalyzing chronicity; and (3) the impact of sexual and reproductive health disparities on chronic disease outcomes.
Preterm Birth and 17OHP — Why the FDA Should Not Withdraw Approval
Authors: Michael F. Greene, Mark A. Klebanoff, David Harrington
Journal: New England Journal of Medicine (2020)

Preterm Birth and 17OHP FDA withdrawal of the approval for 17OHP, as imperfect as the drug may be, will leave a very vulnerable demographic group of U.S. women at high risk for recurrent preterm bi...
Tumor Microenvironment Associated with Complete Response to Tislelizumab Monotherapy in Relapsed/Refractory Classical Hodgkin Lymphoma Reveals a Potentially Different Mechanism of Action
Authors: Yuqin Song, Quanli Gao, Lei Fan, Dehui Zou, Huilai Zhang, Jianfeng Zhou, Wei Li, Haiyan Yang, Ting Liu, Quanshun Wang, Fangfang Lv, Dan Wang, Pei Zhang, Tengfei Liu, Yun Zhang, Zhirong Shen, Lei Wang, Liudi Yang, Haiyi Guo, Jun Zhu
Journal: Blood (2020)
A Cross Sectional Evaluation of Light Chain N-Glycosylation By MASS-FIX in Plasma Cell Disorders
Authors: Patrick Mellors, Surendra Dasari, Mindy Kohlhagen, Bonnie Kaye Arendt, Morie A. Gertz, Shaji K. Kumar, Francis K. Buadi, Maria Alice V. Willrich, John A. Lust, Prashant Kapoor, Martha Q. Lacy, David Dingli, Yi L. Hwa, Amie Fonder, Miriam A. Hobbs, Suzanne R. Hayman, Taxiarchis Kourelis, Rahma M Warsame, Eli Muchtar, Nelson Leung, Ronald S. Go, Yi Lin, Wilson I Gonsalves, Mustaqeem A. Siddiqui, Robert A. Kyle, S. Vincent Rajkumar, David L. Murray, Angela Dispenzieri
Journal: Blood (2020)
Allogeneic Hematopoietic Cell Transplantation (allo-HCT) in T-Cell Prolymphocytic Leukemia (T-PLL): An Analysis from the CIBMTR
Authors: Hemant S. Murthy, Kwang Woo Ahn, Noel Estrada-Merly, Lohith Gowda, Bhagirathbhai Dholaria, Susan Bal, Hassan B. Alkhateeb, Deepa Jagadeesh, Betul Oran, Ryotaro Nakamura, Bart L. Scott, Craig S. Sauter, Francine M. Foss, Mohamed A kharfan-Dabaja, Wael Saber
Journal: Blood (2020)
Abstract 521: Apolipoprotein M Links High-density Lipoprotein to Myocardial Autophagy
Authors: Ali Javaheri, Zhen Guo, Ezhil Chandamarai, Terrence Riehl, Carla Valenzuela Ripoll, Juan Antonio Villa Torrecilla, Michael Rettig, John DiPersio
Journal: Circulation Research (2020)

Background: Apolipoprotein M (APOM) is a lipoprotein that binds sphingosine-1-phosphate (S1P) and high-density lipoprotein (HDL). APOM/S1P attenuate myocardial ischemia/reperfusion injury by reducing infarct size. We recently published that reduced APOM plasma protein levels are associated with mortality across the spectrum of human heart failure. With the goal of uncovering mechanisms by which APOM impacts heart failure mortality, we modeled doxorubicin cardiotoxicity in hepatocyte specific APOM overexpression (APOM TG ) and littermate controls. Results: Doxorubicin treatment acutely reduces APOM plasma protein levels in control mice. APOM TG mice exhibit ~3-5 fold increased APOM and ~2.5 fold increased S1P. In acute and chronic doxorubicin cardiotoxicity models, APOM TG mice were protected from mortality and reductions in left-ventricular mass and ejection fraction observed in littermate controls. In murine models of acute leukemia, doxorubicin effectively killed leukemic cells in control and APOM TG mice. In the myocardium, APOM TG mice and controls had similar levels of γ-H2AX foci after doxorubicin treatment, indicating similar levels of DNA damage, and electron microscopy indicated similar mitochondrial morphology. However, APOM TG mice exhibited enhanced autophagic flux, and APOM prevented doxorubicin-induced reductions in autophagic flux observed in littermate control mice (Figure). Mechanistically, treatment of neonatal rat cardiomyocytes with S1P mimetics attenuated doxorubicin-induced loss of lysosomal pH, suggesting that APOM may enhance lysosomal function via S1P. In the murine myocardium, doxorubicin reduced the nuclear protein content of transcription factor EB (TFEB), a master regulator of autophagy and lysosomal biogenesis, in control mice but not APOM TG mice. Furthermore, adeno-associated virus mediated knockdown of TFEB completely reversed the beneficial effects of APOM on the myocardium, leading to cardiomyopathy and mortality in APOM TG mice. Conclusions: Our studies identify APOM and S1P as regulators of TFEB in the myocardium, hence providing a mechanistic link between HDL and the autophagy-lysosome pathway in the murine heart. The role of APOM in myocardial autophagy may explain our observed clinical associations between reduced APOM and mortality.
Trial in Progress: Glad-AML - a Randomized, Phase 2 Trial of Glasdegib with Two Standard Decitabine Regimens for Older Patients with Newly-Diagnosed, Poor-Risk Acute Myeloid Leukemia
Authors: Rory M. Shallis, Nikolai A. Podoltsev, Thomas Prebet, Amer M. Zeidan
Journal: Blood (2020)
Germline Gain-of-Function <i>JAK3</i> Mutation in Familial Chronic Lymphoproliferative Disorder of NK Cells
Authors: Harry Lesmana, Marcela Popescu, Sara Lewis, Sushree Sangita Sahoo, Charnise Goodings-Harris, Mihaela Onciu, John Kim Choi, Clifford Takemoto, Kim E. Nichols, Marcin Wlodarski
Journal: Blood (2020)
Video consulting contributes to carbon neutral healthcare
Authors: Gemma Johns, Sara Khalil, Mike Ogonovsky, Alka Ahuja
Journal: BMJ (2020)

We at NHS Wales are also working towards contributing to a carbon neutral NHS.1 The NHS in Wales substantially changed the way it delivered care in March 2020 when the covid-19 crisis emerged. The Welsh government issued an emergency response offering primary, secondary, and community care NHS services across all of Wales unlimited use of a new video consulting service, which was implemented and robustly evaluated …
Improvements in Glycemic Control After Acute Moderate-Intensity Continuous or High-Intensity Interval Exercise Are Greater in South Asians Than White Europeans With Nondiabetic Hyperglycemia: A Randomized Crossover Study
Authors: Jack A. Sargeant, Charlotte Jelleyman, Nicole A. Coull, Charlotte L. Edwardson, Joseph Henson, James A. King, Kamlesh Khunti, Matthew McCarthy, Alex V. Rowlands, David J. Stensel, Helen L. Waller, David R. Webb, Melanie J. Davies, Thomas Yates
Journal: Diabetes Care (2020)

OBJECTIVE To examine whether circulating metabolic responses to low-volume high-intensity interval exercise (LV-HIIE) or continuous moderate-intensity aerobic exercise (CME) differ between white Europeans and South Asians with nondiabetic hyperglycemia (NDH). RESEARCH DESIGN AND METHODS Thirteen white Europeans and 10 South Asians (combined median [interquartile range] age 67 [60–68] years, HbA1c 5.9% [5.8–6.1%] [41.0 (39.9–43.2) mmol ⋅ mol−1]) completed three 6-h conditions (sedentary control [CON], LV-HIIE, and CME) in a randomized order. Exercise conditions contained a single bout of LV-HIIE and CME, respectively (each ending at 2 h), with meals provided at 0 and 3 h. Circulating glucose (primary outcome), insulin, insulin resistance index (IRI), triglycerides, and nonesterified fatty acids were measured at 0, 0.5, 1, 2, 3, 3.5, 4, 5, and 6 h. Data were analyzed as postexercise time-averaged area under the curve (AUC) adjusted for age, sex, and preexercise AUC. RESULTS Glucose was similar in each condition and with ethnicity, with no condition-by-ethnicity interaction (P ≥ 0.28). However, insulin was lower in LV-HIIE (mean [95% CI] −44.4 [−23.7, −65.1] mU ⋅ L−1) and CME (−33.8 [−13.7, −53.9] mU ⋅ L−1) compared with CON. Insulin responses were greater in South Asians (interaction P = 0.03) such that values were similar in each ethnicity during exercise conditions, despite being 33% higher in South Asians during CON. IRI followed a similar pattern to insulin. Lipids were unaffected by exercise. CONCLUSIONS Reductions in insulin and insulin resistance after acute LV-HIIE and CME are greater in South Asians than in white Europeans with NDH. Further trials are required to examine the longer-term impact of LV-HIIE and CME on cardiometabolic health.
Fibrin Polymerization Ability Influences Joint Condition in Patients with Severe Haemophilia
Authors: Paula Acuña, Ihosvany Fernandez-Bello, Hortensia de la Corte, María Teresa Alvarez Román, Mónica Martín, María Isabel Rivas Pollmar, Elena Monzón Manzano, Sara García Barcenilla, Tamara Cebanu, Elena G Arias-Salgado, Elena González Zorrilla, Miguel A Canales, Nora V. Butta, Victor Jimenez-Yuste
Journal: Blood (2020)
AML Associated Mesenchymal Stroma Cells Support Growth of AML Cells As a Result of Activated Notch Signaling and This Can be Targeted By Dexamethasone
Authors: Helal Mohammed Mohammed Ahmed Ahmed, Yahya Saleh Al-Matary, Subbaiah Chary Nimmagadda, Maren Fiori, Pradeep Kumar Patnana, Daria Frank, Lanying Wei, Judith Schütte, Tobias May, Joachim R. Goethert, Thomas Schroeder, Ulrike Buttkereit, Christian Recher, Manuel Rodríguez-Paredes, Thorsten Koenig, Wolfgang Hartmann, Jan Tuckermann, Bertram Opalka, Georg Lenz, Cyrus Khandanpour
Journal: Blood (2020)
Metformin Upregulates Mir-26a to Improve Erythropoiesis in Preclinical Models of Diamond Blackfan Anemia through Suppression of Nlk Expression
Authors: Mark C Wilkes, Kavitha Siva, Jacqueline D Mercado, Ethan Patrick Wentworth, Mallika Saxena, Jun Chen, Anupama Narla, Bertil Glader, Shuo Lin, Manuel Serrano, Johan Flygare, Kathleen M. Sakamoto
Journal: Blood (2020)
Genomic Analysis Revealed a Convergent Evolution of LINE-1 in Coat Color: A Case Study in Water Buffaloes (<i>Bubalus bubalis</i>)
Authors: Dong Liang, Pengju Zhao, Jingfang Si, Lingzhao Fang, Erola Pairo-Castineira, Xiaoxiang Hu, Qing Xu, Yali Hou, Yu Gong, Zhengwen Liang, Bing Tian, Huaming Mao, Marnoch Yindee, Md Omar Faruque, Siton Kongvongxay, Souksamlane Khamphoumee, George E Liu, Dong-Dong Wu, James Stuart F Barker, Jianlin Han, Yi Zhang
Journal: Molecular Biology and Evolution (2020)

Abstract Visible pigmentation phenotypes can be used to explore the regulation of gene expression and the evolution of coat color patterns in animals. Here, we performed whole-genome and RNA sequencing and applied genome-wide association study, comparative population genomics and biological experiments to show that the 2,809-bp-long LINE-1 insertion in the ASIP (agouti signaling protein) gene is the causative mutation for the white coat phenotype in swamp buffalo (Bubalus bubalis). This LINE-1 insertion (3′ truncated and containing only 5′ UTR) functions as a strong proximal promoter that leads to a 10-fold increase in the transcription of ASIP in white buffalo skin. The 165 bp of 5′ UTR transcribed from the LINE-1 is spliced into the first coding exon of ASIP, resulting in a chimeric transcript. The increased expression of ASIP prevents melanocyte maturation, leading to the absence of pigment in white buffalo skin and hairs. Phylogenetic analyses indicate that the white buffalo-specific ASIP allele originated from a recent genetic transposition event in swamp buffalo. Interestingly, as a similar LINE-1 insertion has been identified in the cattle ASIP gene, we discuss the convergent mechanism of coat color evolution in the Bovini tribe.
Abstract 555: Sex-Dependent Regulation of Cardiomyocyte Function by Midkine in Pediatric Dilated Cardiomyopathy
Authors: Kc C Woulfe, Cortney E Wilson, Anis Karimpour-Fard, Shelley D Miyamoto, Brian L Stauffer, Carmen SUCHAROV
Journal: Circulation Research (2020)

Background: Pediatric dilated cardiomyopathy (DCM) is a disease with a poor prognosis that affects 1 in 100,000 children. Girls with DCM have worse outcomes than boys, and the mechanisms that lead to these differences are not clear. We have identified a cytokine, midkine (MDK) that is significantly upregulated in the serum from pediatric DCM patients. Circulating MDK is significantly higher in girls with DCM requiring heart transplantation compared to girls with DCM who are stable. Objective: The objective of this study is to determine if MDK impacts cardiomyocyte function in a sex-specific manner in juvenile male and female cells. Methods: Cardiomyocytes isolated from 3 week old juvenile male and female rats (JRVMs) were treated with 1μg MDK for 48 hours. Cardiomyocyte function and calcium dynamics were assessed using an IonOptix system. Myofibril mechanics and calcium sensitivity were measured. In addition, RNA sequencing was completed to identify differentially regulated pathways in juvenile male and female cardiomyocytes in response to MDK. Results: Female JRVMs treated with MDK had higher peak calcium and slower calcium reuptake compared to vehicle-treated female JRVMs. In contrast, male JRVMs treated with MDK did not demonstrate a change in peak calcium and had faster calcium reuptake compared to vehicle-treated male JRVMs. Myofibril calcium sensitivity was decreased in female JRVMs in response to MDK whereas calcium sensitivity was unchanged in male MDK-treated JRVMs. Analysis of the genes that were differentially expressed in cardiomyocytes in response to MDK demonstrated a sex-dependent regulation. Specifically, pathways which regulate calcium handling were only altered in female JRVMs treated with MDK but not in MDK-treated male JRVMs. Conclusions: This study demonstrates sex-specific differences in cardiomyocyte function in response to MDK. Particularly, female cardiomyocytes respond to MDK by regulating genes involved in calcium handling pathways. This suggests that elevated circulating MDK in pediatric DCM patients may lead to different cardiac responses in male and female patients. Therefore, elucidating these sex-specific disease mechanisms is critical to define therapies focused on male and female pediatric DCM patients.
Importance of Early COPD in Young Adults for Development of Clinical COPD. Findings from the Copenhagen General Population Study
Authors: Yunus Çolak, Shoaib Afzal, Børge G. Nordestgaard, Peter Lange, Jørgen Vestbo
Journal: American Journal of Respiratory and Critical Care Medicine (2020)

Individuals who will develop chronic obstructive pulmonary disease (COPD) could be identified at an early age before clinical manifestations appear.
Safety and Efficacy of GBC/GBM Conditioning Regimen Followed By Autologous Stem Cell Transplantation in Lymphoid Malignancies
Authors: Huimin Liu, Wei Liu, Ru Li, Wenyang Huang, Shuhua Yi, Ryu Lv, Shuhui Deng, Gang An, Lugui Qiu, Dehui Zou
Journal: Blood (2020)
Phase 2 Study of the Combination of Daratumumab, Ixazomib, Pomalidomide, and Dexamethasone As Salvage Therapy in Relapsed/Refractory Multiple Myeloma: Stage I Results
Authors: Caitlin L. Costello, Benjamin Brookhart, Matthew J. Wieduwilt, Nina Shah, Carolyn Mulroney, Edward D. Ball
Journal: Blood (2020)
LYG1 Deficiency Attenuates the Severity of Acute Graft-Versus-Host Disease Via Skewing T Cells Polarization Towards Treg Cells
Authors: Huihui Liu, Zhengyu Yu, Bo Tang, Shengchao Miao, Chenchen Qin, Yuan Li, Zeyin Liang, Yang Zhang, Hanyun Ren, Yujun Dong
Journal: Blood (2020)
Post-translation regulation inhibits Claudin-7 expression in invasive breast cancer cells.
Authors: Xinyan Wu, Liangfeng Han, Scott Kominsky, Saraswati Sukumar
Journal: Cancer Research (2005)

323  Claudins are intercellular junction proteins present near the apical end of the lateral membrane surface between epithelial cells. They provide both strong adhesion between adjacent epithelial cells and control the diffusion of material through the intercellular (paracellular) space from one side of the epithelium to the other. It has been well documented that during the progression of metastasis, such as in epithelial-mesenchymal transition, there is loss of the expression of claudins possibly promoting the dissemination of epithelial tumor cells. We have reported previously that expression of the tight junction protein Claudin-7 is lost in ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS), and invasive ductal carcinoma (IDC) of the breast compared to normal mammary epithelium. In contrast to MCF-7 cells where exogenously expressed Claudin 7 mRNA and protein are detectable, in HS578T, MDA-MB-231 and MDA-MB-435 cells only mRNA was detectable, but protein were undetectable. This was not uniformly true of other claudins, since stably transfected Claudins 1, 3 and 4 were easily detectable in all the cell lines. By performing gene swapping experiments between Claudin 3 and Claudin 7, we determined that the N-terminal domain of the protein likely determines protein stability. Furthermore, addition of cytoplasmic extracts of MDA-MB-435 to both endogenous and exogenously expressed Claudin-7 protein in MCF-7-Claudin7-EGFP transfected cell lines resulted in loss of the Claudin-7 protein, but not of other Claudins, like Claudin-3 or Claudin-1, suggesting the presence of factors in these invasive cells that promotes degradation of the protein. The nature of these factors is being investigated. In summary, our preliminary data strongly suggest that a specific regulatory mechanism appear to be occurring at post-translational level in invasive and metastatic breast cancer cells to tightly control the expression of a specific Claudin protein. The relevance of this finding to human breast cancer arises from the loss of Claudin 7 in 50% of primary tumors, and this tight and specific control of Claudin 7 expression gives a clue to the important role for Claudin 7 in tumor progression, and ability of breast cancer cells to metastasize.
Modeling Marginal Zone Lymphomagenesis
Authors: Victor Yazbeck, Ian McConnell, Emily Harris, Joseph Lownik, Ariel Sindel, Roy Sabo, Alden Chesney, Guanhua Lai, Adolfo Mauro, Chad Cain, Fadi N. Salloum, Jamal Zweit, Steven Grant, Jolene Windle, Steven Grossman
Journal: Blood (2020)
Characterization of Protein Unable to Bind Von Willebrand Factor in Recombinant Factor VIII Products: Can We Reduce Their Immunogenicity?
Authors: Haarin Chun, John R Pettersson, Svetlana A Shestopal, Wells W Wu, Ekaterina S Marakasova, Philip Olivares, Stepan S Surov, Mikhail V Ovanesov, Rong-Fong Shen, Timothy K Lee, Andrey G Sarafanov
Journal: Blood (2020)
Donor-Derived T-Cells Specific for WT1 and PRAME in Combination with T-Cells Specific for Multiple Pathogens for Prevention of Relapse and Infection after Haemopoietic Stem Cell Transplant (HSCT) for Acute Myeloid Leukaemia (AML) or High-Risk Myelodysplasia (MDS) - (The INTACT Trial)
Authors: Wei Jiang, Emily Blyth, Peter J. Shaw, Leighton Edward Clancy, Kenneth P. Micklethwaite, Abir Bhattacharyya, Elissa Atkins, Selmir Avdic, Gaurav Sutrave, Janine Street, David Gottlieb
Journal: Blood (2020)