tbuckley/cabot-search huggingface dataset:
The SUMOylation inhibitor subasumstat potentiates rituximab activity by IFN1-dependent macrophage and NK cell stimulation
Authors: Akito Nakamura, Stephen Grossman, Keli Song, Kristina Xega, Yuhong Zhang, Donna Cvet, Allison Berger, Gary Shapiro, Dennis Huszar
Journal: Blood (2022)

Abstract Small ubiquitin-like modifier (SUMO) is a member of a ubiquitin-like protein superfamily. SUMOylation is a reversible posttranslational modification that has been implicated in the regulation of various cellular processes including inflammatory responses and expression of type 1 interferons (IFN1). In this report, we have explored the activity of the selective small molecule SUMOylation inhibitor subasumstat (TAK-981) in promoting antitumor innate immune responses. We demonstrate that treatment with TAK-981 results in IFN1-dependent macrophage and natural killer (NK) cell activation, promoting macrophage phagocytosis and NK cell cytotoxicity in ex vivo assays. Furthermore, pretreatment with TAK-981 enhanced macrophage phagocytosis or NK cell cytotoxicity against CD20+ target cells in combination with the anti-CD20 antibody rituximab. In vivo studies demonstrated enhanced antitumor activity of TAK-981 and rituximab in CD20+ lymphoma xenograft models. Combination of TAK-981 with anti-CD38 antibody daratumumab also resulted in enhanced antitumor activity. TAK-981 is currently being studied in phase 1 clinical trials (#NCT03648372, #NCT04074330, #NCT04776018, and #NCT04381650; www.clinicaltrials.gov) for the treatment of patients with lymphomas and solid tumors.
MicroRNA Profiling of EVI1 Deregulated Myeloid Leukemia
Authors: An De Weer, Bruce Poppe, Pieter Mestdagh, Katleen De Preter, Pieter Van Vlierberghe, Barbara Cauwelier, Nadine Van Roy, Bruno Verhasselt, Jo Vandesompele, Nicole Dastugue, Frank Speleman
Journal: Blood (2008)
Error in Table.
Journal: JAMA (1995)

—In the article entitled "A Meta-analysis of Methods to Prevent Venous Thromboembolism Following Total Hip Replacement," published in the June 8, 1994, issue ofTHE JOURNAL(1994; 271:1780-1785), an incorrect number appeared in Table 1 on page 1781. In the last row, "Warfarin," of the third column, "No. of Patients," the number should be 933 (not 864).
ASSOCIATION NEWS.
Authors: J. McFadden Gaston
Journal: JAMA (1897)

<h3>Recommendation of Section on Neurology. Report of Committee on President's Address.</h3> —Your Committee, to whom was referred the address of the Chairman of the Section, beg leave to report as follows: That they believe it expedient that the work of this Section should be divided and that the part dealing with Medical Jurisprudence should be included in the work of the Section on State Medicine or that a separate Section should be instituted to deal with the subjects included under the term Forensic Medicine. They, however, deem it inexpedient to take any action at this time regarding such a division. They strongly recommend for adoption, the recommendation of the Chairman that the office of the Secretary of the Section so far as possible be made permanent. This can not be done under the By-laws of theAssociation, but the same result can be reached, if those who regularly attend the
A Correction to the Research Article Titled: "Restoration of the Unfolded Protein Response in Pancreatic Cells Protects Mice Against Type 1 Diabetes" by F. Engin, A. Yermalovich, T. Ngyuen, S. Hummasti, W. Fu, D. L. Eizirik, D. Mathis, G. S. Hotamisligil
Journal: Science Translational Medicine (2013)
Band ligation or clipping for diverticular bleeding: quite the quandary
Authors: Suprabhat Giri, Sridhar Sundaram
Journal: Endoscopy (2022)

See also: Effectiveness and adverse events of endoscopic clipping versus band ligation for colonic diverticular hemorrhage: a large-scale multicenter cohort studyEndoscopy eFirstDOI: 10.1055/a-1705-0921 See also: Reply to Drs. Giri and SundaramEndoscopy 2022; 54(03): 338-338DOI: 10.1055/a-1737-4004
Methodological challenges in design and conduct of randomised controlled trials in acupuncture
Authors: Yu-Tong Fei, Hui-Juan Cao, Ru-Yu Xia, Qian-Yun Chai, Chang-Hao Liang, Yu-Ting Feng, Yi-Ran Du, Ming-Kun Yu, Gordon Guyatt, Lehana Thabane, Li-Xing Lao, Jian-Ping Liu, Yu-Qing Zhang
Journal: BMJ (2022)
Hygiene of the Eye.
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PERK is a critical metabolic hub for immunosuppressive function in macrophages
Authors: Lydia N. Raines, Haoxin Zhao, Yuzhu Wang, Heng-Yi Chen, Hector Gallart-Ayala, Pei-Chun Hsueh, Wei Cao, Yeojung Koh, Ana Alamonte-Loya, Pu-Ste Liu, Julijana Ivanisevic, Chan-Wang Jerry Lio, Ping-Chih Ho, Stanley Ching-Cheng Huang
Journal: Nature Immunology (2022)
Patterns of Known and Novel Small RNAs in Human Cervical Cancer
Authors: Weng-Onn Lui, Nader Pourmand, Bruce K. Patterson, Andrew Fire
Journal: Cancer Research (2007)

Abstract Recent studies suggest that knowledge of differential expression of microRNAs (miRNA) in cancer may have substantial diagnostic and prognostic value. Here, we use a direct sequencing method to characterize the profiles of miRNAs and other small RNA segments for six human cervical carcinoma cell lines and five normal cervical samples. Of 166 miRNAs expressed in normal cervix and cancer cell lines, we observed significant expression variation of six miRNAs between the two groups. To further show the biological relevance of our findings, we examined the expression level of two significantly varying miRNAs in a panel of 29 matched pairs of human cervical cancer and normal cervical samples. Reduced expression of miR-143 and increased expression of miR-21 were reproducibly displayed in cancer samples, suggesting the potential value of these miRNAs as tumor markers. In addition to the known miRNAs, we found a number of novel miRNAs and an additional set of small RNAs that do not meet miRNA criteria. [Cancer Res 2007;67(13):6031–43]
Risk of COVID-19 Infections and of Severe Complications Among Survivors of Childhood, Adolescent, and Young Adult Cancer: A Population-Based Study in Ontario, Canada
Authors: Sumit Gupta, Rinku Sutradhar, Sarah Alexander, Michelle Science, Cindy Lau, Chenthila Nagamuthu, Mohammad Agha, Paul C. Nathan, David Hodgson
Journal: Journal of Clinical Oncology (2022)

Survivors of childhood, adolescent, and young adult cancer are at risk of late effects, including pulmonary and infectious complications. Whether survivors are at increased risk of COVID-19 infection and severe complications is unknown.Population-based registries in Ontario, Canada, identified all 5-year survivors of childhood cancer diagnosed age 0-17 years between 1985 and 2014, and of six common adolescent and young adult cancers diagnosed age 15-21 years between 1992 and 2012. Each survivor alive on January 1, 2020, was randomly matched by birth year, sex, and residence to 10 cancer-free population controls. Individuals were linked to population-based laboratory and health care databases to identify COVID-19 tests, vaccinations, infections, and severe outcomes (emergency department [ED] visits, hospitalizations, intensive care unit admissions, and death within 60 days). Demographic, disease, and treatment-related variables were examined as possible predictors of outcomes.Twelve thousand four hundred ten survivors were matched to 124,100 controls. Survivors were not at increased risk of receiving a positive COVID-19 test (386 [3.1%] v 3,946 [3.2%]; P = .68) and were more likely to be fully vaccinated (hazard ratio, 1.23; 95 CI, 1.20 to 1.37). No increase in risk among survivors was seen in emergency department visits (adjusted odds ratio, 1.2; 95 CI, 0.9 to 1.6; P = .19) or hospitalization (adjusted odds ratio, 1.8; 95 CI, 1.0 to 3.5; P = .07). No survivor experienced intensive care unit admission or died after COVID-19 infection. Pulmonary radiation or chemotherapies associated with pulmonary toxicity were not associated with increased risk.Cancer survivors were not at increased risk of COVID-19 infections or severe sequelae. These results can inform risk-counseling of survivors and their caregivers. Further study is warranted to determine risk in older survivors, specific subsets of survivors, and that associated with novel COVID-19 variants.
Training the Next Generation of Clinical Psychological Scientists: A Data-Driven Call to Action
Authors: Dylan G. Gee, Kathryn A. DeYoung, Katie A. McLaughlin, Rachael M. Tillman, Deanna M. Barch, Erika E. Forbes, Robert F. Krueger, Timothy J. Strauman, Mariann R. Weierich, Alexander J. Shackman
Journal: Annual Review of Clinical Psychology (2022)

The central goal of clinical psychology is to reduce the suffering caused by mental health conditions. Anxiety, mood, psychosis, substance use, personality, and other mental disorders impose an immense burden on global public health and the economy. Tackling this burden will require the development and dissemination of intervention strategies that are more effective, sustainable, and equitable. Clinical psychology is uniquely poised to serve as a transdisciplinary hub for this work. But rising to this challengerequires an honest reckoning with the strengths and weaknesses of current training practices. Building on new data, we identify the most important challenges to training the next generation of clinical scientists. We provide specific recommendations for the full spectrum of stakeholders-from funders, accreditors, and universities to program directors, faculty, and students-with an emphasis on sustainable solutions that promote scientific rigor and discovery and enhance the mental health of clinical scientists and the public alike.
BOOK REVIEWS
Authors: EDWARD STADTMAUER
Journal: JNCI Journal of the National Cancer Institute (1991)

BOOK REVIEWS Get access New Strategies in Bone Marrow Transplantation . Richard E. Chaplin Robert Peter Gales , eds. New York : John Wiley and Sons , 1990 , 457 pp. $140. EDWARD STADTMAUER EDWARD STADTMAUER Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 17, 4 September 1991, Page 1254, https://doi.org/10.1093/jnci/83.17.1254 Published: 04 September 1991
Mortality from Congenital Zika Syndrome — Nationwide Cohort Study in Brazil
Authors: Enny S. Paixao, Luciana L. Cardim, Maria C.N. Costa, Elizabeth B. Brickley, Rita C.O. de Carvalho-Sauer, Eduardo H. Carmo, Roberto F.S. Andrade, Moreno S. Rodrigues, Rafael V. Veiga, Larissa C. Costa, Cynthia A. Moore, Giovanny V.A. França, Liam Smeeth, Laura C. Rodrigues, Mauricio L. Barreto, Maria G. Teixeira
Journal: New England Journal of Medicine (2022)

Prenatal exposure to Zika virus has potential teratogenic effects, with a wide spectrum of clinical presentation referred to as congenital Zika syndrome. Data on survival among children with congenital Zika syndrome are limited.
DIET OF TYPHOID FEVER.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of S-1 Plus Oxaliplatin Compared With Fluorouracil, Leucovorin Plus Oxaliplatin as Perioperative Chemotherapy for Locally Advanced, Resectable Gastric Cancer
Authors: Jiren Yu, Yuan Gao, Li Chen, Dan Wu, Qianyun Shen, Zhicheng Zhao, Weihuai Liu, Hanliang Yang, Qi Zhang, Xinbao Wang, Ping Hu, Zhiqiang Zheng, Xianfa Wang, Hongjun Liu, Zekuan Xu, Zhilong Yan, Yingjie Wu, Mingjuan Jin, Qing Zhang, Xiaosun Liu, Kankai Zhu, Chunhui Shou
Journal: JAMA Network Open (2022)

Perioperative chemotherapy is a potential treatment for locally advanced gastric cancer. However, the optimal chemotherapy regimen remains unknown.To investigate the safety and efficacy of S-1 plus oxaliplatin (SOX) vs fluorouracil, leucovorin, and oxaliplatin (FOLFOX) as a perioperative chemotherapy regimen for patients with locally advanced gastric cancer.In this phase 3, open-label, multicenter, randomized clinical trial, patients from 12 Chinese hospitals were enrolled between June 2011 and August 2016, with a last follow-up date of September 2019. The primary tumor was evaluated as either invading the serosa or the adjacent structures with or without metastatic lymph nodes, and with no evidence of distant metastases. Data were analyzed from December 2019 to June 2020.Patients were randomly assigned (1:1) to receive either 6 perioperative (2-4 preoperative and 2-4 postoperative) 3-week cycles of 130 mg/m2 oxaliplatin on day 1 and 80 to 120 mg/d S-1 orally daily for 2 weeks (SOX) or 130 mg/m2 oxaliplatin, 400 mg/m2 fluorouracil, 400 mg/m2 leucovorin, and 2400 mg/m2 fluorouracil as 46-hour infusion on day 1 (FOLFOX).The primary end point was 3-year overall survival (OS). An absolute noninferiority margin of -8% was chosen.A total of 583 patients were enrolled; 293 were randomized to the SOX group and 290 were randomized to the FOLFOX group. Twelve patients (2.1%) refused preoperative chemotherapy (5 patients in the SOX group and 7 patients in the FOLFOX group), leaving a total of 288 patients in the SOX group (median [range] age, 61 [24 to 78] years; 197 men [68.4%]) and 283 patients in the FOLFOX group (median [range] age, 62 [24 to 80] years; 209 men [73.9%]) who received preoperative chemotherapy. The 3-year OS rate was 75.2% (95% CI, 70.3% to 80.5%) in the SOX group and 67.8% (95% CI, 62.5% to 73.5%) in the FOLFOX group. The absolute difference of 3-year OS rate between the 2 groups was 7.4% (95% CI, -0.1% to 14.9%), which was greater than the prespecified noninferiority margin (-8%) and showed the noninferiority of perioperative chemotherapy with SOX compared with FOLFOX.In this randomized clinical trial, SOX was noninferior to FOLFOX as perioperative chemotherapy for patients with locally advanced gastric cancer and could be recommended as an alternative treatment for these patients in Asia.ClinicalTrials.gov Identifier: NCT01364376.
The role of cytokines in cancer cachexia
Authors: Josep M. Argilés, Francisco J. López‐Soriano
Journal: Medicinal Research Reviews (1999)

A large number of observations point towards cytokines, polypeptides released mainly by immune cells, as the molecules responsible for the metabolic derangements associated with cancer-bearing states. Indeed, these alterations lead to a pathological state known as cancer cachexia which is, unfortunately, one of the worst effects of malignancy, accounting for nearly a third of cancer deaths. It is characterized by weight loss together with anorexia, weakness, anemia, and asthenia. The complications associated with the appearance of the cachectic syndrome affect both the physiological and biochemical balance of the patient and have effects on the efficiency of the anticancer treatment, resulting in a considerably decreased survival time. At the metabolic level, cachexia is associated with loss of skeletal muscle protein together with a depletion of body lipid stores. The cachectic patient, in addition to having practically no adipose tissue, is basically subject to an important muscle wastage manifested as an excessive nitrogen loss. The metabolic changes are partially mediated by alterations in circulating hormone concentrations (insulin, glucagon, and glucocorticoids in particular) or in their effectiveness. The present study reviews the involvement of different cytokines in the metabolic and physiological alterations associated with tumor burden and cachexia. Among these cytokines, some can be considered as procachectic (such as tumor necrosis factor-α), while others having opposite effects can be named as anticachectic cytokines. It is the balance between these two cytokine types that finally seems to have a key role in cancer cachexia. © 1999 John Wiley & Sons, Inc. Med Res Rev, 19, No. 3, 223–248, 1999.
Placebo therapy. The ethical dimension
Authors: T. J. Silber
Journal: JAMA (1979)

IN REQUESTING A MEDLINE search on the subject of placebos in English, German, and Spanish (1976 to 1978), I was surprised by the existence of 1,500 articles. When I looked at the number of articles dealing with the ethics of placebo administration, I was surprised again—only 18 of those articles dealt with that issue. There is incongruity between the richness of the pharmacologic, therapeutic, psychiatric, and research literature on this subject in general and the scant attention paid to the moral issues involved. The understanding of the ethical dimension of the diagnostic and therapeutic use of placebos would benefit from more precise examination. <h3>Definitions</h3> First, what is meant by placebo, impure placebo, and placebo effect? "Placebo" (Latin for "I shall please") is defined in<i>Webster's New Collegiate Dictionary</i>(1977) as "a medication prescribed more for the mental relief of the patient than for its actual effect on his disorders."<i>Dorland's</i>
The physician's estate. Part III
Authors: B. Nortell
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Familial Occurrence of Meckel's Diverticulum
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of Food on Drug Absorption
Authors: P. G. Welling
Journal: Annual Review of Nutrition (1996)

This chapter provides an update on drug-food interactions reported in the literature during the past five years. The number of studies examining this phenomenon has increased dramatically, and many of the results of these studies have been unpredictable and spectacular. Drug-food interactions should really be considered as formulation-food interactions because of increasing evidence that a drug may be affected differently by food when it is administered in different formulations. Drug-food interactions may be classified into five categories: those causing reduced, delayed, increased, and accelerated absorption, and those in which food has no effect. While it continues to be necessary to examine drugfood interactions for specific drugs and drug formulations, additional avenues need to be explored to seek mechanistic patterns that may lead to better prediction of the nature and extent of changes in circulating drug levels due to the presense of food, and their possible clinical impact.
Recovery With Temporary Mechanical Circulatory Support While Waitlisted for Heart Transplantation
Authors: Veli K. Topkara, Gabriel T. Sayer, Kevin J. Clerkin, Omar Wever-Pinzon, Koji Takeda, Hiroo Takayama, Craig H. Selzman, Yoshifumi Naka, Daniel Burkhoff, Josef Stehlik, Maryjane A. Farr, James C. Fang, Nir Uriel, Stavros G. Drakos
Journal: Journal of the American College of Cardiology (2022)
Graduate medical education in the United States
Authors: A. E. Crowley
Journal: JAMA (1987)

<h3>INTRODUCTION</h3> This annual report on graduate medical education in the United States for the 1986-1987 academic year contains data on programs accredited by the Accreditation Council on Graduate Medical Education (ACGME), by specialty and by region, and provides information on some characteristics of the persons in these programs. In November 1986, the ACGME through the Residency Review Committee for Internal Medicine accredited programs in nine subspecialties of internal medicine. This action added 1427 new programs to the ACGME system. <h3>RESIDENT AND RELATED TERMS</h3> In the medical education community each of the terms<i>intern, resident</i>, and<i>fellow</i>is used with various meanings. At times the generic term<i>trainee</i>is used to circumvent the ambiguity. Historically, the first year of graduate medical education was called an<i>internship</i>. In 1975, the American Medical Association House of Delegates accepted (on advice from its Council on Medical Education) the recommendation of the Citizens Commission on