tbuckley/cabot-search huggingface dataset:
Immunogenicity and safety of anti-SARS-CoV-2 mRNA vaccines in patients with chronic inflammatory conditions and immunosuppressive therapy in a monocentric cohort
Authors: Ulf M Geisen, Dennis K Berner, Florian Tran, Melike Sümbül, Lena Vullriede, Maria Ciripoi, Hayley M Reid, Annika Schaffarzyk, Ann C Longardt, Jeanette Franzenburg, Paula Hoff, Jan H Schirmer, Rainald Zeuner, Anette Friedrichs, Andrea Steinbach, Christine Knies, Robert DH Markewitz, Peter J Morrison, Sascha Gerdes, Stefan Schreiber, Bimba F Hoyer
Journal: Annals of the Rheumatic Diseases (2021)

In light of the SARS-CoV-2 pandemic, protecting vulnerable groups has become a high priority. Persons at risk of severe disease, for example, those receiving immunosuppressive therapies for chronic inflammatory cdiseases (CIDs), are prioritised for vaccination. However, data concerning generation of protective antibody titres in immunosuppressed patients are scarce. Additionally, mRNA vaccines represent a new vaccine technology leading to increased insecurity especially in patients with CID.Here we present for the first time, data on the efficacy and safety of anti-SARS-CoV-2 mRNA vaccines in a cohort of immunosuppressed patients as compared with healthy controls.42 healthy controls and 26 patients with CID were included in this study (mean age 37.5 vs 50.5 years). Immunisations were performed according to national guidelines with mRNA vaccines. Antibody titres were assessed by ELISA before initial vaccination and 7 days after secondary vaccination. Disease activity and side effects were assessed prior to and 7 days after both vaccinations.Anti-SARS-CoV-2 antibodies as well as neutralising activity could be detected in all study participants. IgG titres were significantly lower in patients as compared with controls (2053 binding antibody units (BAU)/mL ±1218 vs 2685±1102). Side effects were comparable in both groups. No severe adverse effects were observed, and no patients experienced a disease flare.We show that SARS-CoV-2 mRNA vaccines lead to development of antibodies in immunosuppressed patients without considerable side effects or induction of disease flares. Despite the small size of this cohort, we were able to demonstrate the efficiency and safety of mRNA vaccines in our cohort.
P37.19 Activin-A and GDF-11 as Predictive Biomarkers for Platinum Response in Non-Small Cell Lung Cancer
Authors: J. Lim, S. Wong, A. Murphy, A. Nagrial, D. Karikios, D. Daneshvar, R. Mccloy, A. Murphy, S. O'Toole, V. Chin, N. Watkins
Journal: Journal of Thoracic Oncology (2021)
Clinical efficacy of a novel, high-sensitivity HBcrAg assay in the management of chronic hepatitis B and HBV reactivation
Authors: Takako Inoue, Shigeru Kusumoto, Etsuko Iio, Shintaro Ogawa, Takanori Suzuki, Shintaro Yagi, Atsushi Kaneko, Kentaro Matsuura, Katsumi Aoyagi, Yasuhito Tanaka
Journal: Journal of Hepatology (2021)
Abstract 16422: Impact of Diabetes Mellitus on Outcomes After Transcatheter Mitral Valve Repair
Authors: Kranthi K Sitammagari, Kishorbhai Gangani, Sameer Arora, Bharat Reddy Dhanireddy, Venkata S Dontaraju, Pedro A Villablanca
Journal: Circulation (2019)

Background: Short-term mortality was not affected by the presence of diabetes mellitus (DM) after Transcatheter aortic valve replacement based on the work by Abramowitz et al. However, it remains s...
Cost-effectiveness of Brief Behavioral Therapy for Pediatric Anxiety and Depression in Primary Care
Authors: Frances L. Lynch, John F. Dickerson, Michelle S. Rozenman, Araceli Gonzalez, Karen T. G. Schwartz, Giovanna Porta, Maureen O’Keeffe-Rosetti, David Brent, V. Robin Weersing
Journal: JAMA Network Open (2021)

Youth anxiety and depression are common and undertreated. Pediatric transdiagnostic interventions for anxiety and/or depression may be associated with improved access to treatment among youths.To evaluate the cost-effectiveness of a pediatric transdiagnostic brief behavioral therapy (BBT) program for anxiety and/or depression compared with assisted referral to community outpatient mental health care (ARC).In this economic evaluation, an incremental cost-effectiveness analysis was performed from the societal perspective using data from a randomized clinical trial of youths with full or probable diagnoses of anxiety or depression who were recruited from pediatric clinics in San Diego, California, and Pittsburgh, Pennsylvania. The trial was conducted from October 6, 2010, through December 5, 2014, and this analysis was performed from January 1, 2019, through October 20, 2020.In the randomized clinical trial, youths were randomized to BBT (n = 95) or ARC (n = 90). The BBT program consisted of 8 to 12 weekly 45-minute sessions of behavioral therapy delivered in pediatric clinics by master's-level therapists. Families randomized to ARC received personalized referrals to mental health care and telephone calls to support access to care.Anxiety-free days, depression-free days, quality-adjusted life-years (QALYs), and costs based on incremental cost-effectiveness ratios from intake through 32-week follow-up. A cost-effectiveness acceptability curve for QALYs was used to assess the probability that BBT was cost-effective compared with ARC over a range of amounts that a decision-maker might be willing to pay for an additional outcome.Enrolled patients included 185 youths (mean [SD] age, 11.3 [2.6] years; 107 [57.8%] female; 144 [77.8%] White; and 38 [20.7%] Hispanic). Youths who received BBT experienced significantly more anxiety-free days (difference, 28.63 days; 95% CI, 5.86-50.71 days; P = .01) and QALYs (difference, 0.026; 95% CI, 0.009-0.046; P = .007) compared with youths who received ARC. Youths who received BBT experienced more depression-free days than did youths who received ARC (difference, 10.52 days; 95% CI, -4.50 to 25.76 days; P = .18), but the difference was not statistically significant. The mean incremental cost-effectiveness ratio was -$41 414 per QALY (95% CI, -$220 601 to $11 468). The cost-effectiveness acceptability curve analysis indicated that, at a recommended willingness-to-pay threshold of $50 000 per QALY, the probability that BBT would be cost-effective compared with ARC at 32 weeks was 95.6%.In this economic evaluation, BBT in primary care was significantly associated with better outcomes and a greater probability of cost-effectiveness at 32 weeks compared with ARC. The findings suggest that transdiagnostic BBT may be associated with improved youth anxiety and functioning at a reasonable cost.
Virus-inspired surface-nanoengineered antimicrobial liposome: A potential system to simultaneously achieve high activity and selectivity
Authors: Yin Shi, Xiaoqian Feng, Liming Lin, Jing Wang, Jiaying Chi, Biyuan Wu, Guilin Zhou, Feiyuan Yu, Qian Xu, Daojun Liu, Guilan Quan, Chao Lu, Xin Pan, Jianfeng Cai, Chuanbin Wu
Journal: Bioactive Materials (2021)

Enveloped viruses such as SARS-CoV-2 frequently have a highly infectious nature and are considered effective natural delivery systems exhibiting high efficiency and specificity. Since simultaneously enhancing the activity and selectivity of lipopeptides is a seemingly unsolvable problem for conventional chemistry and pharmaceutical approaches, we present a biomimetic strategy to construct lipopeptide-based mimics of viral architectures and infections to enhance their antimicrobial efficacy while avoiding side effects. Herein, a surface-nanoengineered antimicrobial liposome (SNAL) is developed with the morphological features of enveloped viruses, including a moderate size range, lipid-based membrane structure, and highly lipopeptide-enriched bilayer surface. The SNAL possesses virus-like infection to bacterial cells, which can mediate high-efficiency and high-selectivity bacteria binding, rapidly attack and invade bacteria via plasma membrane fusion pathway, and induce a local "burst" release of lipopeptide to produce irreversible damage of cell membrane. Remarkably, viral mimics are effective against multiple pathogens with low minimum inhibitory concentrations (1.6–6.3 μg mL−1), high bactericidal efficiency of >99% within 2 h, >10-fold enhanced selectivity over free lipopeptide, 99.8% reduction in skin MRSA load after a single treatment, and negligible toxicity. This bioinspired design has significant potential to enhance the therapeutic efficacy of lipopeptides and may create new opportunities for designing next-generation antimicrobials.
Abstract P40: PTSD and levels of general anxiety in Italian oncological patients during the COVID-19 pandemic
Authors: Mariam Chichua, Eleonora Brivio, Serena Oliveri, Paolo Guiddi, Gabriella Pravettoni
Journal: Clinical Cancer Research (2021)

Abstract During the COVID-19 pandemic, along with others in Italy, oncological patients had to put their life on hold, adjusting to the new restrictions and complying to the precautionary measures, some of which affected their participation in treatment programs and medical check-ups/health screening tests. The aim of this contribution is to investigate the extent to which the COVID-19 lockdown affected the above-mentioned participation in health screening tests and treatment programs, as well as to study the prodromal levels of PTSD in oncological patients in Italy during the lockdown. A survey consisting of Impact of Event Scale Revised (IES-R), items related to the diagnosis of patients and items regarding treatment and screening tests was shared across several channels. Five-hundred forty-four patients answered the survey. Compared to the screening tests, treatment programs were less affected by COVID-19 restrictions, only 5% of participants had the treatment postponed or interrupted, for the screening tests this number exceeded 30%. The results of linear regression analysis show that overall the level of distress that oncological patients suffered from represents the probable diagnosis of PTSD, with patients who had to stop their regular screening tests showing a higher level of distress compared to those who continued screening (β = 10.78, SE = 1.85, t = 5.84, p = 0.00). These results indicate the need to provide psychological support for oncological patients during future emergency management of catastrophic events such as a pandemic. Citation Format: Mariam Chichua, Eleonora Brivio, Serena Oliveri, Paolo Guiddi, Gabriella Pravettoni. PTSD and levels of general anxiety in Italian oncological patients during the COVID-19 pandemic [abstract]. In: Proceedings of the AACR Virtual Meeting: COVID-19 and Cancer; 2021 Feb 3-5. Philadelphia (PA): AACR; Clin Cancer Res 2021;27(6_Suppl):Abstract nr P40.
Effect of dermatological consultation on survival in patients with checkpoint inhibitor‐associated cutaneous toxicity
Authors: L.L. Thompson, E.B. Li, N.A. Krasnow, M.S. Chang, J.T. Said, G.E. Molina, N.J. Polyakov, J. Yoon, E.C. Dee, K. Huang, A.E. Blum, J.R. Kuchroo, A.N. Hinton, K.L. Reynolds, S.T. Chen
Journal: British Journal of Dermatology (2021)

Background Cutaneous immune-related adverse events (cirAEs) are a common side-effect of immune checkpoint inhibitors (ICIs). However, prior work examining these toxicities in detail has considered only the fraction of events evaluated by dermatologists. Associations between dermatology referral, cirAE treatment and survival outcomes remain underexplored across care settings. Objectives To comprehensively categorize cirAE patterns among all patients treated with immunotherapy at our institution, and to evaluate: (i) the effect of dermatology referral on cirAE treatment and (ii) the impact of cirAE treatment on survival. Methods This was a retrospective cohort analysis of patients with cancer who initiated ICI therapy between 1 January 2016 and 8 March 2019 and developed one or more cirAEs, as screened for using International Classification of Diseases 10th revision codes and confirmed via manual chart review (n = 358). All relevant information documented prior to 31 March 2020 was included. Results CirAEs evaluated by dermatologists were significantly more likely to be treated than cirAEs that were not referred (odds ratio 6·08, P < 0·001). Patients who received any cirAE treatment had improved progression-free survival [hazard ratio (HR) 0·59, P = 0·001] and overall survival (HR 0·58, P = 0·007) compared with those who did not. Conclusions CirAEs evaluated by dermatologists were significantly more likely to be treated than cirAEs that were not referred, and patients who received any treatment for a cirAE had improved survival outcomes.
Development of an Eco-Biodevelopmental Model of Emergent Literacy Before Kindergarten
Authors: John S. Hutton, Thomas DeWitt, Lauren Hoffman, Tzipi Horowitz-Kraus, Perri Klass
Journal: JAMA Pediatrics (2021)

Literacy has been described as an important social determinant of health. Its components emerge in infancy and are dependent on genetic, medical, and environmental factors. The American Academy of Pediatrics advocates a substantial role for pediatricians in literacy promotion, developmental surveillance, and school readiness to promote cognitive, relational, and brain development. Many children, especially those from minority and underserved households, enter kindergarten unprepared to learn to read and subsequently have difficulty in school.Emergent literacy is a developmental process beginning in infancy. Component skills are supported by brain regions that must be adequately stimulated and integrated to form a functional reading network. Trajectories are associated with genetic, medical, and environmental factors, notably the home literacy environment, which is defined as resources, motivation, and stimulation that encourage the literacy development process. Eco-biodevelopmental models are advocated by the American Academy of Pediatrics, and these models offer insights into the neurobiological processes associated with environmental factors and the ways in which these processes may be addressed to improve outcomes. Emergent literacy is well suited for such a model, particularly because the mechanisms underlying component skills are elucidated. In addition to cognitive-behavioral benefits, the association of home literacy environment with the developing brain before kindergarten has recently been described via neuroimaging. Rather than a passive approach, which may subject the child to stress and engender negative attitudes, early literacy screening and interventions that are administered by pediatric practitioners can help identify potential reading difficulties, address risk factors during a period when neural plasticity is high, and improve outcomes.Neuroimaging and behavioral evidence inform an eco-biodevelopmental model of emergent literacy that is associated with genetic, medical, and home literacy environmental factors before kindergarten, a time of rapid brain development. This framework is consistent with recommendations from the American Academy of Pediatrics and provides insights to help identify risk factors and signs of potential reading difficulties, tailor guidance, and provide direction for future research.
Assessing risk for healthcare workers during the covid-19 pandemic
Authors: Kamlesh Khunti, Amanda Griffiths, Azeem Majeed, Chaand Nagpaul, Mala Rao
Journal: BMJ (2021)

### What you need to know

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new strain of coronavirus that causes coronavirus disease 2019 (covid-19). In March 2020, the World Health Organization classified covid-19 as an international pandemic. Initial guidance from many organisations identified people who might be more vulnerable to covid-19, based on knowledge of those known to be most susceptible to adverse outcomes from the influenza virus. Health conditions divided individuals into those who are “extremely vulnerable,” for whom shielding is required, and those at “increased risk of severe illness.”

Studies of hospital admissions and mortality have subsequently enabled identification of more specific risk factors. They include age, sex, and underlying health conditions, the most important of which are diabetes, hypertensive disease, cardiovascular disease, and obesity.1 Concerns have also been raised in the UK and the US about ethnicity as a risk factor, because of the disproportionately higher rates of covid-19 infection and deaths in ethnic minority populations compared with white populations.2 In the UK’s NHS, 21% of staff are from ethnic minority backgrounds, but non-white ethnicities accounted for 75.8% of deaths.3 In the US, Black people account for more than 20% of covid-19 cases among health professionals despite only 5% of doctors and 10% of nurses in the US being from this group.45 The extent to which covid-19 mortality is …
Abstract 17211: Safety and Effectiveness of Trans-Catheter versus Surgical Aortic Valve Replacement in Nonagenarians With Severe Aortic Stenosis: A Systematic Review and Meta-Analysis
Authors: Muhammad Junaid Ahsan, Hafiz Muhammad Fazeel, Saad Ullah Malik, asim tameez ud din, Syeda Hassan, Behram Ahmed Khan, Mydah S Hashmi, Mohsin M Mirza
Journal: Circulation (2019)

Introduction: Nonagenarians i.e. age > 90 are usually not considered for surgical aortic valve replacement (SAVR) owing to their increased surgical risk. This patient population is also under repre...
P33.21 Epidemiological Characteristics and Survival in Patients With Lung Cancer in a Peruvian Private Institution Between 2011-2014
Authors: J.M. Gutierrez, J. Araujo, R. Ruiz, J. Pinto, C. Flores, Z. Morante, E. Amorin, L. Mas
Journal: Journal of Thoracic Oncology (2021)
Abstract 12077: Abbreviation of Eptifibatide Therapy Improves Safety in STEMI Patients Undergoing Primary Percutaneous Coronary Intervention
Authors: Florian Fischer, Samriddhi Buxy, Ulrike Held, David J Kurz, Oliver Senn, Franz R Eberli, Rainer Zbinden, Matthias R Meyer
Journal: Circulation (2019)

Introduction: The glycoprotein IIb/IIIa inhibitor eptifibatide, administered as bolus followed by infusion, is a recommended adjunctive antithrombotic therapy during primary PCI in STEMI patients. ...
Proposal for a Standard Echocardiographic Tricuspid Valve Nomenclature
Authors: Rebecca T. Hahn, Ludwig T. Weckbach, Thilo Noack, Nadira Hamid, Mitsunobu Kitamura, Richard Bae, Philipp Lurz, Susheel K. Kodali, Paul Sorajja, Jörg Hausleiter, Michael Nabauer
Journal: JACC. Cardiovascular imaging (2021)

The purpose of this study was to introduce a novel clinically relevant nomenclature system for the TV and determine the relative incidence of each morphological type. With the rapid development of transcatheter tricuspid valve (TV) repair techniques, there is a growing recognition of the variability in leaflet morphology and a need for a unified nomenclature, which could aid in procedural planning and execution. Patients from 4 medical centers (2 in Europe, 2 in the United States) referred for transesophageal echocardiography (TEE) to assess native TV function, were retrospectively analyzed for leaflet morphology with the use of a novel classification scheme. Four morphological types were identified: type I, 3 leaflets; type II, 2 leaflets; type IIIA, 4 leaflets with 2 anterior; type IIIB, 4 leaflets with 2 posterior; type IIIC, 4 leaflets with 2 septal; and type IV, >4 leaflets. A total of 579 patients were analyzed: mean age 78.1 ± 8.0 years, 50.4% female, 70.9% in atrial fibrillation, and 32.2% with previous left heart surgery or transcatheter intervention. Tricuspid regurgitation was moderate or less in 9.4%, severe in 40.5%, massive in 32.3%, and torrential in 17.7%. The etiology of tricuspid regurgitation was primary in 9.4%, mixed in 10.8%, and secondary in all of the other patients (18.6% atriogenic/isolated). The incidence of type I morphology was 312 of 579 (53.9%), type II was 26 of 579 (4.5%), type IIIA was 15 of 579 (2.6%), type IIIB was 186 of 579 (32.1%), type IIIC was 22 of 579 (3.8%), and type IV was 14 of 579 (2.4%). A novel TV leaflet nomenclature classification scheme can be used to identify 4 types of TV morphologies with the use of TEE imaging. From this multinational retrospective study, the TV has 3 well defined leaflets in only ∼54% of patients and 4 functional leaflets in ∼39% of patients, with type IIIB (2 posterior leaflets) being the most common of the latter. The utility of this classification scheme deserves further study.
P84.13 Organoid Used as Preclinical Modal in ALK Inhibitor Selection: Report of a Case Harbouring LRRTM4–ALK Fusion
Authors: Z. Jia, Z. Bing, Y. Wang, Y. Wang, H. Xu, X. Yang, P. Liu, S. Zhang, S. Li, N. Liang
Journal: Journal of Thoracic Oncology (2021)
The impact of exercise, sleep, and diet on neurocognitive recovery from mild traumatic brain injury in older adults: A narrative review
Authors: Shaun J. Markovic, Melinda Fitzgerald, Jeremiah J. Peiffer, Brendan R. Scott, Stephanie R. Rainey-Smith, Hamid R. Sohrabi, Belinda M. Brown
Journal: Ageing Research Reviews (2021)
Effects of high-dose ifnα2b upon human melanoma regional lymph node metastases: modulation of stat1, stat3, stat5, foxp3 and il-17 during neoadjuvant therapy
Authors: Wenjun Wang, Howard Edington, Uma Rao, Drazen Jukic, Arash Radfar, Hong Wang, Stephanie Land, John Kirkwood
Journal: Cancer Research (2008)

4475  STAT signaling associated with the IFNα receptor plays a pivotal role in the reciprocal differentiation of regulatory T cell and Th17, although this has not been documented fully in vitro and in vivo. Aberrant STAT signaling is associated with melanoma progression and appears to be central to lesions of host anti-tumor immunity and melanoma progression. CD4+CD25+FOXP3+Treg cells are mediators of immunologic tolerance, while Th17 cells are a recently recognized subset of CD4+ helper T cells expressing IL-17, an inflammatory cytokine. During a prospective neoadjuvant trial of high-dose IFNα2b (HDI) we evaluated the impact of IFNα2b on STAT1, STAT3, STAT5, CD4+FOXP3+Treg, and IL-17-expressing T cells pre- and post-treatment in lymph node biopsies. Higher pSTAT1/pSTAT3 ratios in tumor cells correlated with improved survival of melanoma patients. To further demonstrate that STAT3 is a progression biomarker of melanoma risk, we have observed that pSTAT3 expression level is positively associated with the degree of atypia (nevomelanocyte progression) in nevi. To explore the link between STAT signaling and Foxp3 signaling, Foxp3 signal was probed as well. It was found that Foxp3 was expressed in both melanoma and nevotic melanocytes, as well as in lymphocytes, and was associated with proliferation biomarker expression. STAT3 and Foxp3 are inversely associated with melanocyte maturation in vivo. HDI up-regulates pSTAT1, STAT5, and the pSTAT1/pSTAT3 ratio in melanoma cells and/or nevomelanocytes and lymphocytes in vivo, while it down-regulates pSTAT3 and total levels of STAT3 in tumor cells/nevomelanocytes and lymphocytes. The impact of HDI on STAT signaling was found to initiate host anti-tumor immunity with up-regulation of TAP2 antigen presenting machinery, while CD4+FOXP3+Treg cells are up-regulated through STAT5 signaling in response to HDI. IL-17-expression was not induced by IFNα2b in both melanoma and lymphocytes.  Conclusion: IFNα2b modulates host anti-tumor immunity through the reciprocal regulation of STAT1, STAT3 and STAT5 signaling, and the balance of STAT network determines host anti-tumor immunity and tumor progression. STAT signal is associated with Foxp3 signal in vivo. Interference with Foxp3and/or STAT5 pathways may provide and approach to improve the therapeutic index of IFNs. STAT3 and Foxp3 signaling are potential targets for future prevention and therapy.
P19.11 Endobronchial Brachytherapy as Curative Therapy for Postoperative Intrabronchial Oligometastasis in Non-Small Cell Lung Cancer
Authors: A. Ito, S. Kaneda, K. Kawaguchi, A. Shimamoto, M. Kubooka, Y. Nomoto, M. Takao
Journal: Journal of Thoracic Oncology (2021)