tbuckley/cabot-search huggingface dataset:
Accelerated Bone Regeneration by MOF Modified Multifunctional Membranes through Enhancement of Osteogenic and Angiogenic Performance
Authors: Yiyuan Xue, Zhou Zhu, Xin Zhang, Junyu Chen, Xiao Yang, Xiaomeng Gao, Shu Zhang, Feng Luo, Jian Wang, Weifeng Zhao, Chao Huang, Xibo Pei, Qianbing Wan
Journal: Advanced Healthcare Materials (2021)

Owing to the insufficient guidance of new bone formation in orthopedic and craniomaxillofacial surgery, construction of a guided bone regeneration membrane to support vascularized bone regeneration remains a challenge. Herein, an electrospun asymmetric double-layer polycaprolactone/collagen (PCL/Col) membrane modified by metal-organic framework (MOF) crystals is developed. The optimization of the PCL/Col weight ratio (1:1 and 1:1.5) enables the composite membrane with a balanced tensile strength (only fell by 49.9% in wet conditions) and a controlled degradation rate (completely degraded at 12 weeks). The MOF crystals can provide a pH-responsive release of Zn2+ ions. In vitro experiments indicate that the barrier layer functions to prevent the infiltration of fibrous connective tissue. The MOF crystal layer functions to enhance osteogenesis and angiogenesis in vitro. Using a rat calvarial defect model, the MOF crystals exhibit a sign of osteoinductivity along with blood vessel formation after 8 weeks post-surgery. Strikingly, when assessed in a chick chorioallantoic membrane model, the MOF modified membrane demonstrates a significant angiogenic response, which can be envisaged as its outstanding merits over the commercially Col membrane. Therefore, the MOF crystals represent an exciting biomaterial option, with neovascularization capacity for bone tissue engineering and regenerative medicine.
Long-term follow-up of patients with the antibiotic-sterilized aortic homograft valve inserted freehand in the aortic position.
Authors: B GBarratt-Boyes, A HRoche, RSubramanyan, J RPemberton, R MWhitlock
Journal: Circulation (1987)

A series of 252 isolated aortic homograft valves in 248 patients have been followed for 9 to 16.5 years (mean 10.8). The valves were sterilized in antibiotic solution and stored in a nutrient medium at 4 degrees C and were nonvital. There were 15 in-hospital deaths (6%) and a mortality of 2.7% in patients undergoing an elective first operation. Actuarial survival with the study valve in situ was 57% at 10 years and 38% at 14 years. Only 8.4% of the patients died late from homograft valve failure, chiefly because of failure to refer patients with endocarditis for reoperation or because reoperation was refused in elderly, frail subjects. Incompetence was the sole cause of valve failure and was due either to valve wear or endocarditis. Significant incompetence required reoperation. On actuarial analysis, freedom from significant incompetence for the entire group was 95% at 5 years, 78% at 10 years, and 42% at 14 years. Factors increasing the risk of significant incompetence due to valve wear on multivariate ...
Immune Thrombocytopenia—A Neglected Adverse Event of PD-1 and PD-L1 Inhibitors in Clinical Trials
Authors: Xiaocong Pang, Xian Su, Yimin Cui
Journal: JAMA Oncology (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Abnormal distribution of pulmonary blood flow after the Glenn shunt or Fontan procedure: risk of development of arteriovenous fistulae.
Authors: ACloutier, J MAsh, J FSmallhorn, W GWilliams, G ATrusler, R DRowe, MRabinovitch
Journal: Circulation (1985)

Since the Fontan procedure results in low pulsatile pulmonary blood flow similar to that seen in patients with a Glenn shunt, it may also be associated with abnormal distribution of flow to the lower lung lobes and with the development of pulmonary arteriovenous fistulae (PAVF). In 12 patients 0.8 to 4.5 years after Fontan procedure and in 20 patients 0.2 to 18 years after receipt of Glenn shunts we assessed ventilation (with 133Xe) and perfusion (after a peripheral injection of 99mTc-macroaggregated albumin) to compare upper to lower lobe distribution of blood flow with that in a control group. The presence of PAVF was assessed by radionuclide activity in kidneys and the brain and by a two-dimensional echocardiographic contrast study. A decreased upper/lower lobe perfusion ratio was noted in 13 of 20 patients with Glenn shunts (65%) and correlated with the time after surgery (p less than .05). Despite the shorter follow-up period, two of 12 (16%) patients who had undergone the Fontan procedure also had a...
Gastric Precancerous Lesions: Clinical and Endoscopic Predictors
Authors: F Abu Baker, Y Davidov, A Mari, M Arew, M Egbarya, Y Kopelman
Journal: Endoscopy (2021)

Aims Atrophic gastritis, gastric intestinal metaplasia and dysplasia are well defined intermediate precancerous lesions (PCL) in the gastric cancer cascade. The diagnosis of PCL may be suspected based on endoscopic findings, but is established by histology. Unfortunately, estimates of the global prevalence of these lesions vary widely and predictors of their diagnosis are ill defined. We aimed to evaluate the prevalence of gastric PCL in our practice and to identify predictors for its diagnosis.
47P Central nervous-system (CNS) metastases in thymic epithelial tumours (TET): Real-world insight from RYTHMIC
Authors: J.C. Benitez, M-E. Boucher, E. Dansin, M. Kerjouan, L. Bigay-Game, E. Pichon, F. Thillays, P. Falcoz, S. Lyubimova, Y. Oulkhouir, F. Calcagno, L. Thiberville, C. Clément-Duchêne, V. Westeel, P. Missy, P.A. Thomas, T. Molina, N. Girard, B. Besse
Journal: Journal of Thoracic Oncology (2021)
Effects of complement activation in the isolated heart. Role of the terminal complement components.
Authors: J WHomeister, PSatoh, B RLucchesi
Journal: Circulation Research (1992)

The mechanisms of the complement-mediated myocardial injury associated with ischemia and reperfusion have not been elucidated fully. Complement activation may directly mediate injury through actions of the anaphylatoxins C3a and C5a or generation of the membrane attack complex C5b-9. A model was developed to examine the direct effects of complement activation on heart function, assess myocardial tissue damage, and determine which complement components mediate tissue injury. Isolated rabbit hearts were perfused with Krebs-Henseleit buffer by using a modified Langendorff apparatus. Human plasma was added to the perfusate as a source of complement. Rabbit tissue activates human complement. Treatment with 6% normal plasma resulted in complement activation as assessed by the generation of Bb, C3a, C5a, and SC5b-9. Functional changes in cardiac performance became apparent 7-15 minutes after plasma addition and developed fully over the next 20-30 minutes. The effects were dependent on the complement titer and in...
Evaluation and surgical treatment of pulmonary atresia and intact ventricular septum in infancy.
Authors: A BLewis, WWells, G GLindesmith
Journal: Circulation (1983)

The initial surgical approach to the infant with pulmonary atresia and intact ventricular (PA-IVS) is to establish an adequate source of pulmonary blood flow and, when possible, relieve right ventricular (RV) outflow obstruction. The selection of patients for pulmonary valvotomy, alone or in combination with a systemic-pulmonary arterial shunt, depends on the presence of an RV outflow tract and the adequacy of the RV chamber. To evaluate the size of the RV cavity in PA-IVS, an RV index (RVI) was developed using biplane angiographic measurements of the sum of the tricuspid valve annulus and the RV inflow and the RV outflow tracts. The RVI was normalized by relating it to the aortic diameter (Ao) at the diaphragm (RVI/Ao). The RVI/Ao was 13.5 +/- 1.4 in 20 control subjects and only 7.3 +/- 2.6 in 26 PA-IVS patients (p less than 0.001), and was within the normal range in only two of the 26. Since 1976, pulmonary valvotomy plus a Blalock-Taussig shunt has been performed in 10 infants, with one death. Serial c...
A comparison of aortic baroreceptor discharge in normotensive and spontaneously hypertensive rats.
Authors: A MBrown, W RSaum, F HTuley
Journal: Circulation Research (1976)

Electrophysiological characteristics of individual aortic baroreceptors from normotensive rats (NTR) and spontaneously hypertensive rats (SHR) were compared. Impulse activity of afferent fibers was examined following the application of pressure steps to an in vitro aortic arch-aortic nerve preparation. Thirty-one fibers including seven unmyelinated fibers were studied completely over the range of 0-260 mm Hg, using steps 1-30 seconds in duration. The pressure threshold for peak transient discharge of baroreceptors of SHR's was 88.4 +/- 10.1 (mean +/- SE) mm Hg, whereas for baroreceptors of NTR's it was 77.5 +/- 9.3 mm Hg. The pressure threshold for steady state discharge was 137.3 +/- 5.2 mm Hg for SHR baroreceptors and 103.5 +/- 7.1 for NTR baroreceptors. These values compare favorably to measurements in vivo in the rat. The relationship between peak transient impulse frequency and pressure was linear, whereas the relationship between steady state impulse frequency and pressure was hyperbolic. The curvat...
Cycle length alternation in circus movement tachycardia using an atrioventricular accessory pathway. A study of the role of the atrioventricular node using a computer model of tachycardia.
Authors: D LRoss, W RDassen, E JVanagt, PBrugada, F WBär, H JWellens
Journal: Circulation (1982)

The possible role of the atrioventricular nodal (AVN) function curve during tachycardia as a cause of cycle length alternation was investigated using a computer model of circus movement tachycardia utilizing an atrioventricular accessory pathway. Two types of AVN function curves during tachycardia were entered into the computer: straight lines of various gradients and representative examples of patient-based AVN function curves obtained during clinical electrophysiologic studies. Perturbations of the tachycardia model were induced by introducing a short cycle, by suddenly prolonging a conduction interval, or by moving the AVN function curve relative to that in stable tachycardia. Using the straight line AVN function curves, stable, sustained cycle length alternation could be induced by perturbation of the tachycardia cycle if the gradient of the line was -1 (slope = 45 degrees). If the gradient was more than -1 (slope less than 45 degrees), the perturbation was damped. If the gradient was less than -1 (sl...
ERCP-Guided Tissue Acquisition In Intrinsic Biliary Strictures: Still A Long Way To Go!
Authors: CI Puscasu, T Voiosu, G Stoian, D Marica, M Rimbas, F Rouhani, A Voiosu, A Bengus, B Mateescu
Journal: Endoscopy (2021)

Aims Endoscopic retrograde cholangiopancreatography (ERCP) is essential in the workup of intrinsic bile duct strictures, allowing both tissue sampling and drainage of the bile duct. However, the diagnostic yield of ERCP in this setting is suboptimal. We aimed to evaluate the yield of ERCP-guided tissue acquisition in distinct clinical scenarios according to the pre-test probability of malignancy.
SAT0601 MORTALITY RATE IN PATIENTS TREATED WITH BIOLOGICS: DATA FROM THE ROMANIAN REGISTRY OF RHEUMATIC DISEASES
Authors: Catalin Codreanu, Corina Mogosan, Denisa Predeteanu, Simona Rednic, Magda Parvu, Elena Rezus, Ruxandra Ionescu
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background:</h3> Rheumatoid arthritis (RA) is associated with increased mortality, with longitudinal studies averaging a standardised mortality ratio of 1.5 (95%CI 1.2 to 1.8) for RA patients compared to the general population [1]. In contrast, information on mortality in ankylosing spondylitis (AS) is scarce, whereas there are conflicting reports of the mortality risk among patients with psoriatic arthritis (PsA), but it is accepted that patients with PsA do not have a significantly elevated risk of mortality [2]. <h3>Objectives:</h3> To estimate the Mortality Rate in RA, SA and PsA for patients (pts) treated with biologics in Romania. <h3>Methods:</h3> Data were gathered from the Romanian Registry of Rheumatic Diseases (RRBR), which comprises all patients treated with biologics in Romania for RA, AS and PsA. We have studied demographic data, disease duration, exposure to biologics in person-years (PY), and all-cause mortality until 01.01.2018. <h3>Results:</h3> The cohort included 9577 pts (35596.83 PY) as following: 5224 RA pts (18676.75PY), 3469 AS pts (12680.63PY) and 884 PsA pts (4212.45PY). The mean age of the cohort was 54.86 yrs (62.87 yrs for RA, 45.54 yrs for AS, 56.18 yrs for PsA); 3196 pts (33.37%) were men: 79 (1.5%) RA pts, 2681 (77.28%) AS pts and 436 (49.3%) PsA pts. Mean disease duration for the cohort was 16.46 yrs for RA, 11.46 yrs for AS and 10.99 yrs for PsA. The number of all-cause deaths was 89 (74 deaths in RA, 11 in AS and 4 in PsA group). The mortality rate for the entire cohort was 0.25/100PY, and the rate varied across the diseases: 0.39/100PY in RA pts, 0.08/100PY in AS pts and 0.09/100PY in PsA. Infections were the major mortality cause in RA (0.09/100PY) and AS (0.04/100PY). Cardiovascular fatal events occurred in 0.06/100PY in RA population, significantly higher than 0.007/100PY in AS pts. Rate of solid neoplasm death in RA cohort was 0.04/100PY, compared to 0.007/100PY in AS; non-Hodgkin lymphoma was recorded only in RA pts (0.005/100PY). All deaths reported in PsA cohort (4 deaths) were of unknown cause. <h3>Conclusion:</h3> This is the first report on mortality rate in biological treated patients in Romania. These data support data from the literature, showing that RA patients have a higher mortality risk compared to AS and PsA. <h3>References</h3> [1] Dadoun S, Zeboulon Ktorza N, et al. Mortality in rheumatoid arthritis over the last fifty years: systematic review and meta-analysis. Joint Bone Spine. 2013:80(1):29-33 [2] Ogdie A, Haynes K, Troxel AB, et al. Risk of mortality in patients with psoriatic arthritis, rheumatoid arthritis and psoriasis: a longitudinal cohort study. Ann Rheum Dis. 2012;73(1):149-53. <h3>Disclosure of Interests:</h3> None declared
Radiographic assessment of leaflet motion of Gore-Tex laminate trileaflet valves and Hancock xenograft in tricuspid position of dogs.
Authors: EImamura, M PKaye, G DDavis
Journal: Circulation (1977)

Six samples of various thicknessess of Gore-Tex compounds were fashioned into trileaflet valves. A radiopaque marker was placed on the center of the free margin of each cusp, and the prostheses were implanted in the tricuspid position of dogs. Two Hancock valves were studied for comparison. Catheterization revealed that the hemodynamic function was normal in all valves tested. High-speed radiography permitted analysis of leaflet movement throughout the cardiac cycle. Of the six Gore-Tex valves, five opened completely. The cusps of these five valves were fabricated from 4, 6, 8, 10, and 12 layers of Gore-Tex film. The remaining valve, which was fabricated from 15 layers of Gore-Tex film, and both porcine xenograft aortic valves did not open completely. We postulate that the laminates of 12 layers or less of Gore-Tex film are suitable for further study to evaluate their potential applicability in trileaflet cardiac valve prostheses.
Deleterious effects of oxygen radicals in ischemia/reperfusion. Resolved and unresolved issues.
Authors: R AKloner, KPrzyklenk, PWhittaker
Journal: Circulation (1989)

Oxygen free radicals are known to be generated during periods of ischemia followed by reperfusion. There is still some controversy, however, concerning the use of electron paramagnetic resonance spectroscopy to accurately detect and identify the free radical species that are formed. There is no doubt that oxygen radicals are deleterious to the myocardium; free radicals cause left ventricular dysfunction and structural damage to myocytes and endothelial cells in both in vitro and in vivo preparations. Potential sources of these cytotoxic oxygen species include the xanthine oxidase pathway, activated neutrophils, mitochondria, and arachidonate metabolism, yet the crucial source of free radicals in the setting of ischemia and reperfusion is unresolved. There is little doubt that oxygen radicals play a role in the phenomenon of stunned myocardium induced by brief periods of ischemia followed by reperfusion; numerous studies have consistently observed that pretreatment with free radical scavengers and antioxid...
Neurogenic vasodilation of cat cerebral arteries.
Authors: T JLee, W RHume, J ABevan
Journal: Circulation Research (1978)

Transmural nerve stimulation (TNS) with 0.3-msec pulses between 1 and 25 Hz dilated cat cerebral artery segments in the presence of active muscle tone. Maximum vasodilatation occurred at 8 Hz. The dilator response to exogenous acetylcholine, but not to TNS, was abolished by atropine. Neither physostigmine nor hemicholinium affected the dilator response to TNS, which persisted after administration of guanethidine, phenoxybenzamine, propranolol, reserpine, and chronic sympathectomy. However, it was abolished by tetrodotoxin and cold storage. When examined histochemically, cat and rabbit cerebral arteries exhibited a rich plexiform distribution of acetylcholinesterase which was not affected appreciably by sympathetic denervation. These results suggest that vasodilation is not mediated through modification of sympathetic activity. They also indicate the existence of a nonadrenergic, possibly noncholinergic, vasodilator innervation in cat cerebral arteries. Preliminary studies suggest that the transmitter is n...
Changes in plasma catecholamines and dopamine beta-hydroxylase after corrective surgery for coarctation of the aorta.
Authors: C RBenedict, D GGrahame-Smith, AFisher
Journal: Circulation (1978)

In six patients within 12 hours of surgical correction of aortic coarctation there was a 750% increase in plasma noradrenaline concentrations accompanied by an increase in systolic and diastolic blood pressures. The magnitude of the postoperative increase in noradrenaline concentrations was related to the preoperative level of the pressure gradient across the coarctation. Six months after operation plasma noradrenaline concentrations were still significantly elevated. In nine patients who underwent other types of major surgery there was a small increase in plasma noradrenaline concentrations and a return to levels within the normal range within 24 hours. Various explanations for the rise in plasma noradrenaline concentrations are considered. In particular the possibility is raised that after surgical correction of aortic coarctation the increased levels indicate a marked increase in sympathetic nervous system activity; this may be mediated by baroreceptor mechanisms and may persist for up to six months af...
Plasma apoproteins and the severity of coronary artery disease.
Authors: S PSedlis, K BSchechtman, P ALudbrook, B ESobel, GSchonfeld
Journal: Circulation (1986)

Plasma levels of lipids, lipoproteins, and apoproteins in 281 patients undergoing cardiac catheterization were correlated with the incidence and severity of coronary artery disease (CAD) to determine if measurements of apoprotein levels are more predictive of the presence and severity of CAD than the corresponding levels of lipoprotein lipids. In 156 men with CAD among 194 men in the study the only variable other than age that correlated with the severity of CAD, defined by the number of lesions and percent stenosis, was the ratio of apoprotein AI to apoprotein B (r = .1908, p less than .03). The ratio of apoprotein AI to apoprotein B was a more accurate predictor of the severity of CAD than was the ratio of the corresponding high-density to low-density lipoprotein levels (coefficients of partial determination of .07 and .035; p less than .001 and p less than .07, respectively). Multivariate analysis confirmed the independent effect of the ratio of apoprotein AI to apoprotein B on the severity of CAD even...
O leader, where art thou?
Authors: Kamran Abbasi
Journal: BMJ (2021)

What's the role of a medical leader?What's needed to head a college, medical association, or health service?Is it about supporting colleagues who experience unprecedented levels of abuse and violence from frustrated patients? 1 Is it about charting a clear path to revive training affected by the pandemic, as Clara Munro and colleagues argue? 2 Is it about tackling institutional discrimination, as the Royal College of Surgeons must now do, 3 or protecting staff wellbeing, 4 or solving access problems in primary care? 5
Environmental Influences on the Human Microbiome and Implications for Noncommunicable Disease
Authors: Jiyoung Ahn, Richard B. Hayes
Journal: Annual Review of Public Health (2021)

The human microbiome contributes metabolic functions, protects against pathogens, educates the immune system, and through these basic functions, directly or indirectly, affects most of our physiologic functions. Here, we consider the human microbiome and its relationship to several major noncommunicable human conditions, including orodigestive tract cancers, neurologic diseases, diabetes, and obesity. We also highlight the scope of contextual macroenvironmental factors (toxicological and chemical environment, built environment, and socioeconomic environment) and individual microenvironmental factors (smoking, alcohol, and diet) that may push the microbiota toward less healthy or more healthy conditions, influencing the development of these diseases. Last, we highlight current uncertainties and challenges in the study of environmental influences on the human microbiome and implications for understanding noncommunicable disease, suggesting a research agenda to strengthen the scientific evidence base.
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Authors: Pablo Martínez-Legazpi, Javier Bermejo, Yolanda Benito, Raquel Yotti, Candelas Pérez del Villar, Ana González-Mansilla, Alicia Barrio, Eduardo Villacorta, Pedro Luis Sánchez, Francisco Fernández-Avilés, Juan C. del Álamo
Journal: Journal of the American College of Cardiology (2015)