Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19
Authors: Simin  Florescu, Delia Stanciu, Mihaela  Zaharia, Alma  Kosa, Daniel Codreanu, Aneela Kidwai, Sobia Masood, Callum Kaye, Amanda Coutts, Lynn MacKay, Charlotte Summers, Petra  Polgarova, Neda Farahi, Eleonore Fox, Stephen McWilliam, Daniel Hawcutt, Laura Rad, Laura O’Malley, Jennifer Whitbread, Dawn Jones, Rachael Dore, Paula  Saunderson, Olivia Kelsall, Nicholas Cowley, Laura Wild, Jessica Thrush, Hannah Wood, Karen Austin, János Bélteczki, István Magyar, Ágnes Fazekas, Sándor Kovács, Viktória Szőke, Adrian Donnelly, Martin Kelly, Naoise Smyth, Sinéad O’Kane, Declan McClintock, Majella Warnock, Ryan  Campbell, Edmund McCallion, Amine  Azaiz, Cyril Charron, Mathieu Godement, Guillaume Geri, Antoine Vieillard-Baron, Paul Johnson, Shirley McKenna, Joanne Hanley, Andrew Currie, Barbara Allen, Clare  McGoldrick, Moyra McMaster, Ashwin Mani, Meghena Mathew, Revathi Kandeepan, C Vignesh, Bharath TV, N Ramakrishnan, Augustian  James, Evangeline Elvira , Devachandran Jayakumar,  Ramachandran Pratheema,  Suresh Babu, R Ebenezer, S Krishnaoorthy, Lakshmi Ranganathan, Manisha Ganesan, Madhu Shree, Eileen Guilder, Magdalena Butler, Keri-Anne Cowdrey, Melissa Robertson, Farisha Ali, Ellie McMahon, Eamon Duffy, Yan Chen, Catherine Simmonds, Rachael McConnochie, Caroline O’Connor, Khaled El-Khawas, Angus Richardson, Dianne Hill, Robert Commons, Hussam Abdelkharim, Rajeev Jha, Michael Kalogirou, Christine Ellis, Vinodh Krishnamurthy, Aibhilin O’Connor, Saranya Thurairatnam, Dipak Mukherjee, Agilan Kaliappan, Mark Vertue, Anne Nicholson, Joanne Riches, Gracie Maloney, Lauren Kittridge, Amanda Solesbury, Angelo Ramos, Daniel Collins, Kathy Brickell, Liadain Reid, Michelle Smyth, Patrick Breen, Sandra Spain, Gerard Curley, Natalie McEvoy, Pierce Geoghegan, Jennifer Clarke , Jon Silversides, Peter McGuigan, Kathryn Ward, Aisling O’Neill, Stephanie Finn, Chris Wright, Jackie Green, Érin Collins, Cameron Knott, Julie Smith, Catherine Boschert, Kitty Slieker, Esther Ewalds, Arnate Sanders, Wendy Wittenberg, Heidi Geurts, Brenda Reeve, William Dechert , Barbara  Phillips, Laura Oritz-Ruiz de Gordoa, Julia Affleck, Yogesh Apte, Umesh Subbanna, Roland Bartholdy, Thuy Frakking, Jez Pinnell, Matt  Robinson, Lisa Gledhill, Tracy Wood, Karuna Keat, Deepak Bhonagiri, Ritesh Sanghavi, Jodie Nema, Megan Ford, Harshel Parikh, Bronwyn Avard, Mary Nourse, Oscar Hoiting, Marco Peters, Els Rengers, Mirjam Evers, Anton Prinssen, Matt Morgan, Jade  Cole, Helen Hill, Michelle Davies, Angharad  Williams, Emma Thomas, Rhys Davies, Matt Wise, Patrick Grimm, Jens Soukup, Richard Wetzold, Madlen Löbel, Lisa Starke, Francois  Lellouche, Patricia Lizotte, Pierre Declerq, Marchalot  Antoine, Gelinotte Stephanie, Eraldi Jean-Pierre, Bourgerol  François, Beuzelin  Marion, Rigaud Philippe, Franck Pourcine, Mehran Monchi, David Luis, Romain Mercier, Anne Sagnier, Nathalie Verrier, Cecile Caplin, Jack Richecoeu, Daniele Combaux, Shidasp Siami, Christelle Aparicio, Sarah Vautier, Asma Jeblaoui, Delphine Lemaire-Brunel, Frédérick Carbonneau, Julie Leblond, Gaetan  Plantefeve, Cécile Leparco, Damien Contou, Muriel Fartoukh, Laura Courtin, Vincent Labbe, Guillaume Voiriot, Sara Salhi, Michaël Chassé, François Carrier, Dounia  Boumahni, Fatna Benettaib, Ali Ghamraoui, Arnaud Sement, Alexandre Gachet, Alexis Hanisch, Abdelmagid Haffiane, Anne-Hélène Boivin, Amelie Barreau, Elodie Guerineau, Séverine Poupblanc, Pierre Egreteau, Montaine Lefevre, Simon Bocher, Guillaume Le Loup, Lenaïg Le Guen, Vanessa Carn, Melanie Bertel, David Antcliffe, Maie  Templeton, Roceld Rojo, Phoebe Coghlan, Joanna  Smee, Gareth Barker, André Finn, Gabriele Kreß, Uwe Hoff, Carl Hinrichs, Jens Nee, Euan  Mackay, Jon Cort, Amanda Whileman, Thomas Spencer, Nick Spittle, Sarah Beavis, Anand Padmakumar, Katie Dale, Joanne Hawes, Emma Moakes, Rachel  Gascoyne, Kelly Pritchard, Lesley Stevenson, Justin Cooke, Karolina Nemeth-Roszpopa, Basanta Gauli, Sirjana Bastola, Grégoire Muller, Mai-Anh Nay, Toufik Kamel, Dalila Benzekri, Sophie Jacquier, Isabelle Runge, Armelle Mathonnet, François Barbier, Anne Bretagnol, Jay Carter, Kymbalee Van Der Heyden, Jan Mehrtens, Anna Morris, Stacey Morgan, Tara Burke, Emmanuelle Mercier, Delphine Chartier, Charlotte Salmon, Pierre-François Dequin, Denis Garot, David Bellemare, Ève  Cloutier, Rana  Daher, Olivier Costerousse, Marie-Claude Boulanger, Émilie Couillard-Chénard, François Francoeur , Bruno Francois, Alexandra Gay, Fedou Anne-Laure, Mohamed Ramali, Ooi HC, Alison Ghosh, Rawlings Osagie, Malka Arachchige, Melissa Hartley, Winston Cheung, Mark Kol, Helen Wong, Asim Shah, Atul Wagh , Peter Bamford, Andrew Reid, Kathryn Cawley, Maria Faulkner, Charlotte Pickering, Ashok  Raj, Georgios Tsinaslanidis, Reena  Khade, Gloria Agha, Rose Sekiwala, Tim Smith, Chris Brewer, Jane Gregory, James Limb, Amanda Cowton, Julie O’Brien, Kelly Postlethwaite, Salim Malakouti , Edvin Music, Dan Ricketts, Andrew King, Gilles Clermont, Robert Bart, Florian Mayr, Andrew Schoenling, Mark Andreae, Varun Shetty, Emily Brant, Brian Malley, Chenell Donadee, Rachel Sackrowitz, Alexandra Weissman, Donald Yealy, David Barton, Nadine Talia, Nikitas Nikitas, Colin Wells, Liana Lankester, Helen McMillan, Huub van den Oever, Arriette Kruisdijk-Gerritsen, Ghady  Haidar, William Bain, Ian Barbash, Meghan Fitzpatrick, Christopher Franz, Georgios Kitsios, Kaveh Moghbeli, Brian Rosborough, Faraaz Shah, Tomeka Suber, Mark Pulletz, Patricia Williams, Jenny Birch, Sophie Wiseman, Sarah Horton, Ana Alegria, Salah Turki, Tarek Elsefi, Nikki Crisp, Louise Allen, Nicholas Truman, Matthew Smith, Sri Chukkambotla, Wendy Goddard, Stephen Duberley, Meherunnisa Khan, Aayesha Kazi, Joanna Simpson, Graeme Duke, Peter Chan, Brittney Carter, Stephanie Hunter, Ingo Voigt, Robert Schueler, Elisabeth Blank, Vanessa Hüning, Melanie Steffen, Patricia Goralski, Adrian Regli, Susan Pellicano, Annamaria Palermo, Ege Eroglu , Russell Laver, Tapaswi Shrestha, Xia Jin , Craig French, Samantha Bates, Miriam Towns, Yang Yang, Forbes McGain, Iain McCullagh, Tom Cairns, Helen Hanson, Bijal Patel, Ian Clement, George Evetts, Omar  Touma, Susan Holland, Christopher Hodge, Holly Taylor, Meera Alderman, Nicky Barnes, Joana Da Rocha, Catherine Smith, Nicole Brooks, Thanuja Weerasinghe, Julie-Ann Sinclair, Yousuf Abusamra, Ronan Doherty, Joanna  Cudlipp, Rajeev Singh, Haili Yu, Admad  Daebis, Christopher NG, Sara  Kendrick, Anita Saran, Ahmed  Makky, Danni Greener, Louise Rowe-Leete, Alexandra Edwards, Yvonne Bland, Rozzie Dolman, Tracy Foster, John Laffey, Bairbre McNicholas, Michael Scully, Siobhan  Casey, Maeve Kernan, Aoife Brennan, Ritika Rangan, Riona Tully, Sarah Corbett, Aine  McCarthy, Oscar Duffy, David Burke, Vanessa Linnett, Amanda Sanderson, Jenny Ritzema, Helen Wild, Rachael Lucas, Yvonne Marriott, Zdravko Andric, Sabina Cviljevic, Renata Đimoti, Marija Zapalac, Gordan Mirković, Divya Khare, Meredith Pinder, Amitha  Gopinath, Thogulava Kannan, Steven Dean, Piyush Vanmali, Pieter Depuydt, Jan De Waele, Liesbet De Bus, Jan Fierens, Stephanie Bracke, Joris Vermassen, Daisy Vermeiren, Richard Pugh, Richard Lean, Xinyi Qiu, Jeremy Scanlan, Andrew Evans, Gwyneth Davies, Joanne Lewis, Yvonna Plesnikova, Ahmed Khoud, Samantha Coetzee, Kathryn Puxty, Susanne Cathcart, Dominic Rimmer, Catherine Bagot, Kathryn Scott, Laila Martin, Hakeem Yusuff, Graziella Isgro, Chris Brightling, Michelle Bourne, Michelle Craner, Rebecca Boyles, Brian Alexander, Tracey Roberts, Apoorva Nelli, Rachel Rosenstein-Sisson, Rebecca Speyer, Yadira Pech, James McCullough, Mandy Tallott, Gloria Vazquez-Grande, Nicole Marten, Theresa Liu, Atif Siddiqui, Sushil Khanal, Sameena Amatya , Tamas  Szakmany, Shiney Cherian, Gemma Williams, Christie James, Abby Waters, Rachel Prout, Roger Stedman, Louisa Davies, Suzannah Pegler, Lynsey Kyeremeh, Louise Moorhouse, Gill Arbane, Marina Marotti, Aneta Bociek, Sara Campos, Kees van Nieuwkoop, Thomas Ottens, Yorik Visser, Lettie  van den Berg, Annemarie van der Kraan-Donker , Stephen Brett, Sonia  Arias, Rebecca Hall, Hem Paneru, Sabin Koirala, Pratibha Paudel, Maggie Wilson, Suvi Vaara, Leena Pettilä, Jonna Heinonen, Ville Pettilä, Susan Jain, Abhinav Gupta, Catherine  Holbrook, Pierre Antoine, Ferhat Meziani, Hayat Allam, Jessy Cattelan, Raphael Clere-Jehl, Julie Helms, Christine Kummerlen, Hamid Merdji, Alexandra Monnier, Hassene Rahmani, Studer Antoine, Francis Schneider, Vincent Castelain, Guillaume Morel, Sylvie L’Hotellier, Evelina Ochin, Christian Vanjak, Patrick Rouge, Lynda Bendjemar, Martin Albert, Karim Serri, Alexandros Cavayas, Mathilde Duplaix, Virginie Williams, Nuno José Teodoro Amaro dos Santos Catorze, Tiago Nuno Alfaro Lima Pereira, Ricardo Manuel Castro Ferreira, Joana Margarida Pereira Sousa Bastos, Teresa Margarida Oliveira Batista , Julio Badie, Fernando Berdaguer, Sylvain Malfroy, Chaouki Mezher, Charlotte Bourgoin, Guy Moneger, Elodie Bouvier, Rosana Muñoz-Bermúdez, Judith Marin-Corral, Anna Degracia, Francisco Gómez, Maria López , Romina Aceto, Alessio Aghemo, Salvatore Badalamenti, Enrico Brunetta, Maurizio Cecconi, Michele Ciccarelli, Elena Constantini, Massimiliano Greco, Marco Folci, Carlo Selmi, Antonio Voza, Jeremy Henning, Stephen Bonner, Keith Hugill, Emanuel  Cirstea, Dean Wilkinson, Jessica Jones, Mohammed Altomy, Michal Karlikowski, Helen Sutherland, Elva Wilhelmsen, Jane Woods, Julie North, Mathias Pletz, Stefan Hagel, Juliane Ankert, Steffi Kolanos, Frank Bloos, Koen Simons, Tamara van Zuylen, Angela Bouman, Nikhil Kumar, Rakshit Panwar, Gail Brinkerhoff, Cassandra Koppen, Federica Cazzola, Gábor Szigligeti, János Leszkoven, Bram Rochwerg, Tim Karachi, Simon Oczkowski, John Centofanti, Tina Millen, Dhinesh Sundaran, Laszlo Hollos, Anna Williams, Margaret  Turns, Joanne  Walsh, Eman Al Qasim, Lolowa Alswaidan, Mohamed Hegazy, Hatim Arishi, Ali Al Amri, Samah AlQahtani, Brintha Naidu, Haytham Tlayjeh, Sajid Hussain, Farhan Al Enezi, Sheryl Ann Abdukahil , Phil Hopkins, John Smith, Harriet  Noble, Kevin O’Reilly, Reena Mehta, Onyee  Wong, Esther Makanju, Deepak Rao, Nyma  Sikondari, Sian Saha, Ele Corcoran, Evita Pappa, Maeve Cockrell, Clare Donegan, Morteza Balaie, Daniela Nickoleit-Bitzenberger, Bernhard Schaaf, Werner Meermeier, Katharina Prebeg, Harun Azzaui, Martin Hower, Klaus-Gerd Brieger, Corinna Elender, Timo Sabelhaus, Ansgar Riepe, Ceren Akamp, Julius Kremling, Daniela Klein, Elke Landsiedel-Mechenbier, Shondipon Laha, Mark Verlander, Alexandra Williams, Avinash Jha, Bruno Megarbane, Sebastian Voicu, Nicolas Deye, Isabelle Malissin, Laetitia Sutterlin, Aymen Mrad, Adrien Lehalleur, Giulia Naim, Philippe Nguyen, Jean-Michel Ekhérian, Yvonnick Boué, Georgios Sidéris, Dominique Vodovar, Emmanuelle Guérin, Caroline Grant, Matthew Brain, Sarah Mineall, Elankumaran Paramasivam, Elizabeth Wilby, Bethan Ogg, Clare Howcroft, Angelique Aspinwall, Sam Charlton, Richard Gould, Deena Mistry, Sidra Awan, Caroline Bedford, Joanne  Carr-Wilkinson, Andrew Hall, Jill Cooke, Caroline Gardiner-Hill, Carolyn Maloney, Nigel Brunskill, Olivia Watchorn, Chloe Hardy, Hafiz Qureshi, Neil Flint, Sarah Nicholson, Sara Southin, Andrew Nicholson, Amardeep Ghattaoraya, Daniel Harding, Sinead O’Halloran, Amy Collins, Emma Smith, Estefania Trues, Barbara Borgatta, Ian Turner-Bone, Amie Reddy, Laura Wilding, Craig Wilson, Zuhra Surti, Hayden White, Kristen Estensen, Lynette Morrison, Joanne Sutton, Melanie Cooper, Loku Warnapura, Ronan Agno, Prasannakumari  Sathianathan, Deborah Shaw, Nazia Ijaz, Adam Spong, Suganya Sabaretnam, Dean Burns, Eva Lang, Margaret Tate, Roy Fischer, Vishwanath Biradar, Natalie Soar, David Golden, Miriam Davey, Rebecca Seaman, Alexander Osborne, Jonathan Bannard-Smith, Richard Clark, Kathrine Birchall, Joanne Henry, Fiona Pomeroy, Rachael Quayle, Katharine Wylie, Anila Sukuraman, Maya John, Sindhu Sibin, Kosar Khwaja, Josie Campisi, Marit van Vonderen, Mario Pietersma, Loes Vrolijk, Linda Kampschreur , Laura van Gulik, Arystarch Makowski, Beata Misztal, Syeda Haider, Angela Liao, Rebecca Squires, Aneta Oborska, Abdul Kayani, Selver Kalchko-Veyssal, Rajalakshmi Prabakaran, Bernard Hadebe, Selver KalchkoVeyssal, Tony Williams, Rima Song, Vivian Lai, Hannah  Habraken  , Richard Stewart, Esther Mwaura, Louise Mew, Lynn Wren, Felicity Willams, Sara-Beth Sutherland, Rashmi Rebello, Yahya Shehabi, Wisam Al-Bassam, Amanda Hulley, Umesh Kadam, Kushaharan Sathianathan, Richard Innes, Patricia Doble, Libby Graham, Charmaine Shovelton, Tessa Dean, Nawal Salahuddin, Diptesh Aryal, Kanchan Koirala, Namrata Rai, Subekshya Luitel, Ian Seppelt, Christina Whitehead, Julie Lowrey, Rebecca Gresham, Kristy Masters, Vincent Hamlyn, Nancy Hawkins, Anna Roynon-Reed, Sean Cutler, Sarah Lewis, Juan Lazaro, Tabitha Newman, Erick Duan, Jennifer Tsang, Lisa Patterson, Pauline Austin, Susan Chapman, Louise Cabrelli, Simon Fletcher, Jurgens Nortje, Deirdre Fottrell-Gould, Georgina Randell, Katie Stammers, Gail Healey, Marta Pinto, Zoe Borrill, Tracy Duncan, Andrew Ustianowski, Alison Uriel, Ayaa Eltayeb, Jordan Alfonso, Samuel Hey, Joanne Shaw, Claire Fox, Gabriella Lindergard, Bethan Charles, Bethany Blackledge, Karen Connolly, Jade Harris, Jeronimo Cuesta, Kugan Xavier, Dharam Purohit, Munzir Elhassan, Anne Haldeos, Rachel Vincent, Marwa Abdelrazik, Samuel Jenkins, Arunkumar Ganesan, Rohit Kumar, David Carter, Dhanalakshmi Bakthavatsalam, Alasdair Frater, Malik Saleem, Robert Everitt, Danielle Hacking, Mohsin Zaman, Einas Elmahi, Andrea Jones, Kathryn Hall, Gary Mills, Ajay Raithatha, Kris Bauchmuller, Kim Ryalls, Kate Harrington, Helen Bowler, Jas Sall, Richard Bourne, Jamie Gross, Natalie Massey, Olumide Adebambo, Matilda Long, Kiran Tony, Nicole Juffermans, Matty Koopmans, Romein Dujardin, Bashar Alderink , Matthew Rowland, Paula Hutton, Archana Bashyal, Neil Davidson, Clare Hird, Manish Chhablani, Gunjan Phalod, Amy Kirkby, Simon Archer, Kimberley  Netherton, Henrik Reschreiter, Julie Camsooksai, Sarah Patch, Sarah Jenkins, Charlotte Humphrey, Peter Kruger, James Walsham, Jason Meyer, Meg Harward, Ellen Venz, Sonia Sathe, Lisa Roche, Ellie Davies, Denise Skinner, Jane Gaylard, Julie Newman, David Pogson, Steve Rose, Zoe Daly, Lutece Brimfield, Angie Nown, Dhruv Parekh, Colin Bergin, Michelle Bates, Christopher McGhee, Daniella Lynch, Khushpreet Bhandal, Kyriaki Tsakiridou, Amy Bamford, Lauren Cooper, Tony Whitehouse, Tonny Veenith, Elliot Forster, Martin O'Connell, Malcolm Sim, Sophie Hay, Steven Henderson, Maria Nygren, Eliza Valentine, Amro Katary, Gillian Bell, Louise Wilcox, Michail Mataliotakis, Paul Smith, Murtaza Ali, Agah Isguzar, Mandeep-Kaur Phull, Abbas Zaidi, Tatiana Pogreban, Lace Rosaroso, Daniel Harvey, Benjamin Lowe, Megan Meredith, Lucy Ryan, Jeroen Schouten, Peter Pickkers, Noortje Roovers, Margreet Klop-Riehl, Hetty van der Eng, Sonja Sloots-Cuppen, Lieke Preijers, Nienke van Oosten, Pierre Moine, Nicholas Heming, Virginie Maxime, Isabelle Bossard, Tiphaine Nicholier, Bernard Clair, David Orlikowski, Rania Bounab, Lilia Abdeladim, Eric Sy, Jonathan Mailman, Stephen Lee, Chiraag Gupta, Sandy Kassir, Rafael López, Jorge Rodríguez-Gómez, Sheila Cárcel, Rosario Carmona, Carmen de la Fuente, Marina Rodriguez,  Robert  Jan Hassing, Frances Greven, Danique Huijbens, Harald Roebers, Helen Miles, Antony Attokaran, Ulrike Buehner, Erin Williams, Samuel Gluck, Stephanie O’Connor, Marianne Chapman, Kathleen Glasby, Demetrios Kutsogiannis, Patricia Thompson, Kevin Rooney, Natalie Rodden, Nicola Thomson, Deborah McGlynn, Lynn Abel, Lisa Gemmell, Radha Sundaram, James Hornsby, Andrew Walden, Liza Keating, Matthew Frise, Sabi Rai, Shauna Bartley, Martin Schuster-Bruce, Sally Pitts, Rebecca Miln, Laura Purandare, Luke Vamplew, Brijesh Patel, Debra Dempster, Mahitha Gummadi, Natalie Dormand, Shu Wang, Michael Spivey, Sarah Bean, Karen Burt, Lorraine Moore, Fiona Hammonds, Carol Richards, Lewis Campbell, Kirsty Smyth, Margaret Phillips, Christopher Day, Letizia Zitter, Sarah Benyon, Jayaprakash Singh, Ceri  Lynch, Justyna Mikusek, Bethan Deacon, Keri Turner, Evelyn Baker, John Hickey, Shreekant Champanerkar, Lindianne  Aitken, Lorraine LewisProsser, Norfaizan  Ahmad, Matt Wiles, Jayne Willson, Irina Grecu, Jane Martin, Caroline Wrey Brown, Ana-Marie Arias, Emily Bevan, Samantha Westlake, Thomas Craven, David Hope, Jo Singleton, Sarah Clark, Corrienne McCulloch, Simon Biddie, Ingeborg Welters, David Hamilton, Karen Williams, Victoria Waugh, David Shaw, Suleman Mulla, Alicia Waite, Jaime Roman, Maria Martinez, Brian Johnston, Zudin Puthucheary, Timothy Martin, Filipa Santos, Ruzena  Uddin, Maria Fernandez, Fatima Seidu, Alastair Somerville, Mari-Liis Pakats, Salma Begum, Tasnin  Shahid, Jeffrey Presneill, Deborah Barge, Kathleen Byrne, Alana Driscoll, Louise Fortune, Pierre Janin, Elizabeth Yarad, Frances Bass, Naomi Hammond, Anne O’Connor, Alain Vuylsteke, Charles Chan, Saji Victor, Sharon Waterson, Robert McNamara, David Gattas, Heidi Buhr, Jennifer Coles, Ramprasad Matsa, Minerva Gellamucho, Ben Creagh-Brown, Cheryl Marriot, Armorel Salberg, Louisa Zouita, Sarah Stone, Natalia Michalak, Sinead Donlon, Shelia Mtuwa, Irving Mayangao, Jerik Verula, Dorota Burda, Celia Harris, Emily Jones, Paul Bradley, Esther Tarr, Lesley Harden, Charlie Piercy, Jerry Nolan, Ian Kerslake, Tim Cook, Tom Simpson, James Dalton, Carrie Demetriou, Sarah Mitchard, Lidia Ramos, Katie White, Toby Johnson, William Headdon, Stephen Spencer, Alison White, Lucy Howie, Michael Reay, Steve Jenkins, Angela Watts, Eleanor Traverse, Stacey Jennings, Vikram Anumakonda, Caroline Tuckwell, Karen Pearson, Kath Harrow, Julie Matthews, Karen McGarry, Vanessa Moore, Lucie Smith, Anna Summerfield, Paul Dark, Alice Harvey, Reece Doonan, Liam McMorrow, Karen Knowles, Jessica Pendlebury, Stephanie Lee, Jane Perez, Tracy Marsden, Melanie Taylor, Angiy  Michael, Matthew Collis, Andrew Claxton, Wadih Habeichi, Dan Horner, Melanie Slaughter, Vicky Thomas, Nicola Proudfoot, Claire Keatley, Phil Donnison, Ruth Casey, Ben Irving, Wadzanai Matimba-Mupaya, Catherine Reed, Alpha Anthony, Fiona Trim, Lenka Cambalova, Debra Robertson, Anna Wilson, Jonathan Hulme, Santhana Kannan, Fiona Kinney, Ho Senya, Anne Hayes, Valli Ratnam, Mandy Gill, Jill Kirk, Sarah Shelton, Sacha Schweikert, Bradley Wibrow, Matthew Anstey, Rashmi Rauniyar, Nasir Khoso, Namra Asif, Huda Taqdees, Christian Frey, Riccardo Scano, Madeleine McKee, Peter Murphy, Matt Thomas, Ruth Worner, Beverley Faulkner, Emma Gendall, Kati Hayes, Hayley Blakemore, Borislava Borislavova, Kush Deshpande, Pam Konecny, Jennene Miller, Adeline Kintono, Raymond Tung, Leanne Hayes, Lorna Murphy, Andy Neill, Bryan Reidy, Michael O’Dwyer, Donal Ryan, Kate Ainscough, Colin Hamilton-Davies, Carmen Chan, Celina Mfuko, Hakam Abbass, Vineela Mandadapu, Susannah Leaver, Kamal Patel, Sarah Farnell-Ward, Romina Saluzzio, Sam Rawlins, Christine Sicat, Adrian De Keulenaer, Janet Ferrier, Ed Fysh, Ashlish Dawda, Bhaumik Mevavala, Deborah Cook, Frances Clarke, Dorota Banach, Ziortza  Fernández de Pinedo Artaraz, Leilani Cabreros, Victoria Latham, Rebecca Kruisselbrink, Laurent Brochard, Karen Burns, Gyan Sandhu, Imrana Khalid , Ian White, Maria Croft, Nicky Holland, Rita Pereira, Priya Nair, Hergen Buscher, Claire Reynolds, Sally Newman, John Santamaria, Leanne Barbazza, Jennifer Homes, Roger Smith, Ahmed Zaki, David Johnson, Hywel Garrard, Vera Juhaz, Louise Brown, Abigail Pemberton, Alistair Roy, Anthony Rostron, Lindsey Woods, Sarah Cornell, Rob Fowler, Neill Adhikari, Maneesha Kamra, Nicole Marinoff , Peter Garrett, Lauren Murray, Jane Brailsford, Loretta Forbes, Teena Maguire, Gerard Fennessy, John Mulder, Rebecca Morgan, Rebecca McEldrew, Suresh Pillai, Rachel Harford, Helen Ivatt, Debra Evans, Suzanne Richards, Eilir Roberts, James Bowen, James Ainsworth, Anne Kuitunen, Sari Karlsson, Annukka Vahtera, Heikki Kiiski, Sanna Ristimäki, Jonathan Albrett, Carolyn Jackson, Simon Kirkham, Kadri Tamme, Veronika Reinhard, Anneli Ellervee, Liisi Põldots, Pille Rennit, Nikolai Svitškar, Troy Browne, Kate Grimwade, Jennifer Goodson, Owen Keet, Owen Callender, Andrew Udy, Phoebe McCracken, Meredith Young, Jasmin Board, Emma Martin, Vidya Kasipandian, Amit Patel, Suzanne Allibone, Roman Mary-Genetu, Shane English, Irene Watpool, Rebecca Porteous, Sydney Miezitis, Lauralyn McIntyre, Kara Brady, Cassandra Vale, Kiran Shekar, Jayshree Lavana, Dinesh Parmar, Sandra Peake, Catherine Kurenda, Anil Hormis, Rachel Walker, Dawn Collier, Sarah Kimpton, Susan Oakley, Sanjay Bhagani, Mark De Neef, Sara Garcia, Amitaa  Maharajh, Aarti Nandani, Jade Dobson, Gloria Fernando, Christine Eastgate, Keith Gomez, Zakee Abdi, Kate Tatham, Shaman Jhanji, Ethel Black, Arnold Dela Rosa, Ryan Howle, Ravishankar Baikady, Redmond Tully, Andrew Drummond, Joy Dearden, Jennifer Philbin, Sheila Munt, Shameer Gopal, Jagtar- Singh Pooni, Saibal Ganguly, Andrew Smallwood, Stella Metherell, Anas Naeem, Laura Fagan, Emily Ryan, Vasanth Mariappa, Judith Smith, Angela Foulds, Adam Revill, Binita Bhattarai, Evert de Jonge, Jeanette Wigbers, Michael del Prado, Olaf Cremer, Jelle Mulier, Anna Peters, Birgit Romberg, Roger Schutgens, Darren Troeman, Marjolein van Opdorp, Henny Besten, Karen Brakké, Russell Barber, Anette Hilldrith, Stefan Kluge, Axel Nierhaus, Dominik Jarczak, Kevin Roedl , Matthias Kochanek, Giusi Rueß-Paterno, Josette Mc-Kenzie, Dennis Eichenauer, Alexander Shimabukuro-Vornhagen, Elizabeth Wilcox, Lorenzo del Sorbo, Hesham Abdelhady, Tina Romagnuolo , Scott Simpson, Matthew Maiden, Allison Bone, Michelle Horton, Tania Salerno, Vladimir Krajinovic, Marko Kutleša, Viktor Kotarski, Farooq Brohi, Vijay Jagannathan, Michele Clark, Sarah Purvis, Bill Wetherill, Ana Brajković, Jakša Babel, Helena Sever, Lidija Dragija, Ira Kušan, Ahilanandan  Dushianthan, Rebecca Cusack, Kim de Courcy-Golder, Karen Salmon, Rachel Burnish, Simon Smith, Susan Jackson, Winningtom  Ruiz, Zoe Duke, Magaret  Johns, Michelle Male, Kirsty Gladas, Satwinder  Virdee, Jacqueline Swabe, Helen Tomlinson, Gernot Rohde, Achim Grünewaldt, Jörg Bojunga, Sirak Petros, Kevin Kunz, Bianka Schütze, Dirk Weismann, Anna Frey, Maria Drayss, M.E. Goebeler, Thomas Flor, Gertrud Fragner, Nadine Wahl, Juliane Totzke, Cyrus Sayehli, Jeremy Bewley, Katie Sweet, Lisa Grimmer, Rebekah Johnson, Rachel Wyatt, Karen Morgan, Siby Varghese, Joanna Willis, Emma Stratton, Laura Kyle, Daniel Putensen, Kay Drury, Agnieszka Skorko, Pamela Bremmer, Geraldine Ward, Christopher Bassford, Wendy Sligl, Nadia Baig, Oleksa Rewa, Sean Bagshaw, Kim Basile, Dara Stavor, Dylan Burbee, Amanda McNamara, Renee Wunderley, Nicole Bensen, Aaron Richardson, Peter Adams, Tina Vita, Megan Buhay, Denise Scholl, Matthew Gilliam, James Winters, Kaleigh Doherty, Emily Berryman, Mehrdad Ghaffari, Oscar Marroquin, Kevin Quinn, William Garrard, Kyle Kalchthaler, Gregory Beard, Aimee Skrtich, Kavitha Bagavathy, Debra Drapola, Kayla Bryan-Morris, John Arnold, Bob Reynolds, Mahwish Hussain, Janice Dunsavage, Salim Saiyed, Erik Hernandez, John Goldman, Cynthia Brown, Susan Comp, James Raczek, Jenny Morris, Jesus Vargas Jr., Daniel Weiss, Joseph Hensley, Erik Kochert, Chris Wnuk, Christopher Nemeth, Brent Mowery, Christina Hutchinson, Lauren Winters, David McAdams, Gena Walker, Tami Minnier, Mary Wisniewski, Katelyn Mayak, Erin McCreary, Elise Martin, Ryan Bariola, Alex Viehman, Jessica Daley, Alyssa Lopus, Mark Schmidhofer, Richard Ambrosino, Sherbrina  Keen, Sue Toffalo, Martha Stambaugh, Ken Trimmer, Reno Perri, Sherry Casali, Rebecca Medva, Brent Massar, Ashley Beyerl, Jason Burkey, Sheryl Keeler, Maryalyce Lowery, Lynne Oncea, Jason Daugherty, Chanthou Sevilla, Amy Woelke, Julie Dice, Lisa Weber, Jason Roth, Cindy Ferringer, Deborah Beer, Jessica Fesz, Lillian Carpio, Gwenhael Colin, Vanessa Zinzoni, Natacha Maquigneau, Matthieu Henri-Lagarrigue, Caroline Pouplet, Lorenz Reill, Michael Distler, Astrid Maselli, Robert Martynoga, Kara Trask, Amelia Butler, Ben Attwood, Penny Parsons, Bridget Campbell, Alex Smith, Valerie Page, Xiao Zhao, Deepali Oza, Gail Abrahamson, Ben Sheath, Chiara Ellis, Paul Young, Chelsea Young, Eden Lesona, Leanlove Navarra, Raulle Cruz, Kirsha Delaney, Rhoze Cruz, April Aguilar-Dano, Jonathan Rhodes, Thomas Anderson, Sheila Morris, Ralph Fuchs, Bridget Lambert, Charlotte Tai, Amy Thomas, Alexandra Keen, Carey Tierney, Nimca Omer, Gina Bacon, Ascanio Tridente, Karen Shuker, Jeanette Anders, Sandra Greer, Paula Scott, Amy Millington, Philip Buchanan, Jodie Kirk, Alexandra Binnie, Elizabeth Powell, Alexandra McMillan, Tracy Luk, Noah Aref, Craig Denmade, Girendra  Sadera, Reni Jacob, Cathy Jones, Debbie Hughes, Martin Sterba, Wenli Geng, Stephen Digby, David Southern, Harsha Reddy, Sarah Hulse, Andrew Campbell, Mark Garton, Claire Watkins, Sara Smuts, Alison Quinn, Benjamin Simpson, Catherine McMillan, Cheryl Finch, Claire Hill, Josh Cooper, Joanna Budd, Charlotte Small, Ryan O’Leary, Janine Birch, Emma Collins, Andrew Holland, Peter Alexander, Tim Felton, Susan Ferguson, Katharine Sellers, Luke Ward, David Yates, Isobel Birkinshaw, Kay Kell, Zoe Scott, Harriet Pearson, Madiha Hashmi, Maryam Ali, Noor Hassan, Ashok Panjwani, Zulfiqar Umrani, Mohiuddin Shaikh, Ayesha Siddiqui, Quratul Ain, Darakhshan Kanwal, Sjoerd van Bree, Marianne Bouw-Ruiter, Margreet Osinga, Arthur  van Zanten , Claire Zammit , Sumayyah Rashan, Nora Azergui, Sara Bari, Mercedes Beltran, Curt Brugman, Erika Groeneveld, Mina Jafarzadeh, Nicole Keijzer-Timmers, Esmee Kester, Maaike Koelink, Marion Kwakkenbos-Craanen, Clementina Okundaye, Lorraine Parker, Svenja Peters, Sophie Post, Ilse Rietveld, Irma Scheepstra-Beukers, Gerwin Schreuder, Albertine Smit , Nicole Brillinger, René Markgraf, Fred Eichinger, Peter Doran, Aisha  Anjum, Janis Best-Lane, Elizabeth Fagbodun, Frances Barton, Walton Charles, Lorna Miller, Karen Parry-Billings, Sam Peters, Alvin Richards-Belle, Michelle Saull, Stefan Sprinckmoller, Daisy Wiley, Robert Darnell, Carly Au, Lucy Stronach, Aidan Burrell, Andrew Forbes, Stephane Heritier, Manoj Saxena, Tony Trapani, Brian Cuthbertson, Venika Manoharan, Arjen Dondrop, Deva Jayakumar, Stephan Ehrmann, Sebastiaan Hullegie, Pedro Povoa, Richard Beasley, Nick Daneman, Robert Fowler, Steve McGloughlin, David Paterson, Bala Venkatesh, Menno de Jong, Tim Uyeki, Kenneth Baillie, Madhia Hashmi, Mihai Netea, Katrina Orr, Asad Patanwala, Steve Tong, Nichola Cooper, James Galea, Kayode Ogungbenro, Asad Patawala, Emma Rademaker, Steven Tong, Taryn Youngstein, Dean Fergusson, Anand Kumar, Mike Laffan, Sylvain Lother, Angelique de Man, Marie-Helene Masse, Jacinta Abraham, Donald Arnold, Phillipe Begin, Richard Charlewood, Michael Chasse, Jamie Cooper, Mark Coyne, James Daly, Iain Gosbell, Heli Harvala-Simmonds, Sheila MacLennan, John McDyer, David Menon, Nicole Pridee, David Roberts, Helen Thomas, Alan Tinmouth, Darrell Triulzi, Tim Walsh, Erica Wood, Carolyn Calfee, Cecilia O’Kane, Murali Shyamsundar, Pratik Sinha, Taylor Thompson, Ian Young, Niall Ferguson, Carol Hodgson, Neil Orford, Jason Phua, Rebecca Baron, Slava  Epelman, Claudia  Frankfurter, Frank  Gommans, Edy Kim, David  Leaf, Muthiah Vaduganathan, Roland van Kimmenade, Ashish Sanil, Marloes van Beurden, Evelien Effelaar, Joost Schotsman, Craig Boyd, Cain Harland, Audrey Shearer, Jess Wren, Giles Clermont, Daniel Ricketts, Udara Attanayaka, Sri Darshana, Pramodya Ishani, Ishara  Udayanga, Charlotte A. Bradbury, Patrick R. Lawler, Simon J. Stanworth, Bryan J. McVerry, Zoe McQuilten, Alisa M. Higgins, Paul R. Mouncey, Farah Al-Beidh, Kathryn M. Rowan, Lindsay R. Berry, Elizabeth Lorenzi, Ryan Zarychanski, Yaseen M. Arabi, Djillali Annane, Abi Beane, Wilma van Bentum-Puijk, Zahra Bhimani, Shailesh Bihari, Marc J. M. Bonten, Frank M. Brunkhorst, Adrian Buzgau, Meredith Buxton, Marc Carrier, Allen C. Cheng, Matthew Cove, Michelle A. Detry, Lise J. Estcourt, Mark Fitzgerald, Timothy D. Girard, Ewan C. Goligher, Herman Goossens, Rashan Haniffa, Thomas Hills, David T. Huang, Christopher M. Horvat, Beverley J. Hunt, Nao Ichihara, Francois Lamontagne, Helen L. Leavis, Kelsey M. Linstrum, Edward Litton, John C. Marshall, Daniel F. McAuley, Anna McGlothlin, Shay P. McGuinness, Saskia Middeldorp, Stephanie K. Montgomery, Susan C. Morpeth, Srinivas Murthy, Matthew D. Neal, Alistair D. Nichol, Rachael L. Parke, Jane C. Parker, Luis F. Reyes, Hiroki Saito, Marlene S. Santos, Christina T. Saunders, Ary Serpa-Neto, Christopher W. Seymour, Manu Shankar-Hari, Vanessa Singh, Timo Tolppa, Alexis F. Turgeon, Anne M. Turner, Frank L. van de Veerdonk, Cameron Green, Roger J. Lewis, Derek C. Angus, Colin J. McArthur, Scott Berry, Lennie P. G. Derde, Steve A. Webb, Anthony C. Gordon
Journal: JAMA (2022)

<h3>Importance</h3> The efficacy of antiplatelet therapy in critically ill patients with COVID-19 is uncertain. <h3>Objective</h3> To determine whether antiplatelet therapy improves outcomes for critically ill adults with COVID-19. <h3>Design, Setting, and Participants</h3> In an ongoing adaptive platform trial (REMAP-CAP) testing multiple interventions within multiple therapeutic domains, 1557 critically ill adult patients with COVID-19 were enrolled between October 30, 2020, and June 23, 2021, from 105 sites in 8 countries and followed up for 90 days (final follow-up date: July 26, 2021). <h3>Interventions</h3> Patients were randomized to receive either open-label aspirin (n = 565), a P2Y12 inhibitor (n = 455), or no antiplatelet therapy (control; n = 529). Interventions were continued in the hospital for a maximum of 14 days and were in addition to anticoagulation thromboprophylaxis. <h3>Main Outcomes and Measures</h3> The primary end point was organ support–free days (days alive and free of intensive care unit–based respiratory or cardiovascular organ support) within 21 days, ranging from −1 for any death in hospital (censored at 90 days) to 22 for survivors with no organ support. There were 13 secondary outcomes, including survival to discharge and major bleeding to 14 days. The primary analysis was a bayesian cumulative logistic model. An odds ratio (OR) greater than 1 represented improved survival, more organ support–free days, or both. Efficacy was defined as greater than 99% posterior probability of an OR greater than 1. Futility was defined as greater than 95% posterior probability of an OR less than 1.2 vs control. Intervention equivalence was defined as greater than 90% probability that the OR (compared with each other) was between 1/1.2 and 1.2 for 2 noncontrol interventions. <h3>Results</h3> The aspirin and P2Y12 inhibitor groups met the predefined criteria for equivalence at an adaptive analysis and were statistically pooled for further analysis. Enrollment was discontinued after the prespecified criterion for futility was met for the pooled antiplatelet group compared with control. Among the 1557 critically ill patients randomized, 8 patients withdrew consent and 1549 completed the trial (median age, 57 years; 521 [33.6%] female). The median for organ support–free days was 7 (IQR, −1 to 16) in both the antiplatelet and control groups (median-adjusted OR, 1.02 [95% credible interval {CrI}, 0.86-1.23]; 95.7% posterior probability of futility). The proportions of patients surviving to hospital discharge were 71.5% (723/1011) and 67.9% (354/521) in the antiplatelet and control groups, respectively (median-adjusted OR, 1.27 [95% CrI, 0.99-1.62]; adjusted absolute difference, 5% [95% CrI, −0.2% to 9.5%]; 97% posterior probability of efficacy). Among survivors, the median for organ support–free days was 14 in both groups. Major bleeding occurred in 2.1% and 0.4% of patients in the antiplatelet and control groups (adjusted OR, 2.97 [95% CrI, 1.23-8.28]; adjusted absolute risk increase, 0.8% [95% CrI, 0.1%-2.7%]; 99.4% probability of harm). <h3>Conclusions and Relevance</h3> Among critically ill patients with COVID-19, treatment with an antiplatelet agent, compared with no antiplatelet agent, had a low likelihood of providing improvement in the number of organ support–free days within 21 days. <h3>Trial Registration</h3> ClinicalTrials.gov Identifier:NCT02735707