Effect of Subcutaneous Casirivimab and Imdevimab Antibody Combination vs Placebo on Development of Symptomatic COVID-19 in Early Asymptomatic SARS-CoV-2 Infection
Authors: Meagan P. O’Brien, Eduardo Forleo-Neto, Neena Sarkar, Flonza Isa, Peijie Hou, Kuo-Chen Chan, Bret J. Musser, Katharine J. Bar, Ruanne V. Barnabas, Dan H. Barouch, Myron S. Cohen, Christopher B. Hurt, Dale R. Burwen, Mary A. Marovich, Elizabeth R. Brown, Ingeborg Heirman, John D. Davis, Kenneth C. Turner, Divya Ramesh, Adnan Mahmood, Andrea T. Hooper, Jennifer D. Hamilton, Yunji Kim, Lisa A. Purcell, Alina Baum, Christos A. Kyratsous, James Krainson, Richard Perez-Perez, Rizwana Mohseni, Bari Kowal, A. Thomas DiCioccio, Gregory P. Geba, Neil Stahl, Leah Lipsich, Ned Braunstein, Gary Herman, George D. Yancopoulos, David M. Weinreich, Neal Warshoff, Liudmila Moreiras, Dario Altamirano, Dickson Ellington, Faisal Faikih, William Smith, Richard Gibson, Katie Buckner, Robert Rosen, Amy Sapp, Anita Kohli, Vicki McIntyre, Yessica Sachdeva, Amanda McFarland, Dina Gibson, Kenneth Kim, Jason Ahn, Lisa Neinchel, Nayna Paryani, Amber Mottola, Eva Day, Martha Navarro, Rafaelito Victoria, Xanthe Victoria, Rene Uong, Mindy Sampson, Christopher Polk, Michael Leonard, Lewis McCurdy, Leigh A. Medaris, Zainab Shahid, Lisa Davidson, Jawad Nazir, John Lee, Amy Elliott, Swami Sathyanaryan, Mansi Oberoi, Muhammad (Danial) Siddiqui, Muhammad Arsad, Kara Bruning, Sybil Hosek, Temitope Oyedele, Vanessa Sarda, Monica Mercon, Kathryn Stephenson, Boris Juelg, Chen Sabrina Tan, Rebecca Zash, Ai-ris Collier, Jessica Ansel, Kate Jaegle, Lilia Roque-Guerrero, Ana Gomez Ramirez, Javier Capote, Gisel Paz, Michael Paasche-Orlow, Julien Dedier, Sanjay Vadgama, Ramachandra Patak, Nicolas Chronos, Cary Hefty, Judith Borger, Ifeanyi Momodu, Lindsey Carswell, Benjamin King, Ryan Starr, Scott Syndergaard, Nancy Patel, Ravikumar Patel, Ryan Sattar, Jeffrey Unger, Sheila De Jesus-Maranan, Cecilia Casaclang, Michael Seep, Celeste Brown, Joshua Whatley, Dennis Levinson, Saad Alvi, Norman James, Azazuddin Ahmed, Robinson Koilpillai, Stephanie Cassady, Jennifer Cox, Eduardo Torres, Mark J. Rosenthal, Michael Winnie, Jerry Plemons, Omesh Verma, Richard Leggett, Ramon Reyes, Keith Beck, Brian Poliquin, Murtaza Mussaji, Jignesh Shah, David Sutton, Edward Pereira, Rodel Gloria, Stacey Kelly, Amy Dennis-Saltz, Mae Sheikh-Ali, Elias Saikali, James Magee, Rebecca Goldfaden, Haresh Boghara, Sunny Patel, Bari Eichelbaum, Duane Anderson, Sean Su, Alexander Akhavan, Diana Kirby, Joy Venglik, Kenneth Mayer, Taimur Khan, Marcy Gelman, Faisal A. Fakih, Faisal M. Fakih, Daniel Layish, Fernando Alvarado, Jose Diaz, Augusto Focil, Griselda Rosas, Stevan Correa, Michael Bogseth, Bhaktasharan Patel, Gary Tarshis, Katrina Grablin, Paul Simonelli, Stanley Martin, Alvin Sharma, Anna Chen, Pragya Dhaubhadel, Shaeesta Khan, Sreelatha Naik, Sudheer Penupolu, Thulashie Sivarajah, Tae-Sung Kwon, Lakshmi Saladi, Farbod Raiszadeh, Sharon Mannheimer, Raji Ayinla, Khaing Myint, Akari Kyaw, Donna Dowie, Robin O'Reilly, Hussein Assallum, Lovelyamma Varghese, Ellen Morrison, Julie Franks, Jun Avelino Loquere, Orlando Rosario, Andrea Low, Joan Villacrucis, Alan Skolnick, Harold Minkowitz, David Leiman, Todd Price, Anatoli Krasko, Idisoro Wiener, Larry Reed, Oscar Lin, Mayur Ramesh, George Alangaden, Suraj Saggar, Thomas Birch, Benjamin De La Rosa, Karyna Neyra, Erina Kunwar, Jeffrey Kingsley, April Pixler, Veronica McBride, Judith Aberg, Michelle Cespedes, Alexandra Abrams-Downey, Erna Kojic, Luz Lugo, Sean Liu, Nadim Salomon, David Perlman, Deena Altman, Farah Rahman, Georgina Osorio, Joseph Mathew, Sanjana Koshy, Dana Mazo, Francesca Cossarini, Sondra Middleton, Alina Jen, Erika Maria Reategui Schwarz, Miguel Trevino, Benjamin DeVries, Vidya Menon, Moiz Kasubhai, Usha Venugopal, Anjana Pillai, Franscene Oulds, Matthew Hong, Wayne Harper, Lynn Eckert, Douglas Wadeson, Lisa Cohen, Joel Chua, Shyam Kottilil, Jennifer Husson, John Baddley, R. Gentry Wilkerson, Shivakumar Narayanan, Uzoamaka Eke, Myint Noe, Melanie Malave Sanchez, Arthur Kim, Greg Robbins, Mark Siedner, Rajesh Gandhi, Kristen Hysell, Jacob Lazarus, Lael Yonker, Roberto Arduino, Karen J. Vigil, Carlos J. Bello, Esperanza Arce-Nunez, Jorge Acosta, Julio L. Arronte, Eric Meissner, Patrick Flume, Andrew Goodwin, Deeksha Jandhyala, Nandita Nadig, Robert Jeanfreau, Susan Jeanfreau, Susan Tortorich, Shiva Akula, Paul Matherne, Donald Gaddy, Magdy Mikhail, Rajasekaran Annamalai, Huy Nguyen, Nizar Nayani, Mahalakshmi Ramchandra, Priyesh Mehta, Jacqueline Horne, Grace Hassan, Godson Oguchi, Judepatricks Onyema, Moti Ramgopal, Brenda Jacobs, Lisa Cason, Angela Trodglen, Adrian Streinu, Daniela Manolache, Anca Streinu-Cercel, Oana Sandulescu, Ana Blanaru, Monica Stoica, Ana Maria Andone, Daniela Dospinoiu, Silviu Serban, Loredana Patru, Christina Buhuara, Ramona Dorobantu, Magdalena Motoi, Ioana Daramus, George Bihoi, Alexandra Ghita, Victor Miron, Gylda Spataru, Amesika Nyaku, Shobha Swaminathan, Terence Chang, Robbyn Traylor, Lenee Gordon, John McDivitt, Lizette Castro, Douglas Young, Gary Carson, Angelica Kottkamp, Mark J. Mulligan, Anna Bershteyn, Vanessa Raabe, Tamia Davis, Mary Olson, Seuli Brill, Carlos Malvestutto, Susan Koletar, Taru Saigal, Mahdee Sobhanie, Vignesh Doraiswamy, Mahrous Abo Hassan, Jeremy Young, Edwin DeJesus, Charlotte-Paige Rolle, Federico Hinestrosa, Dan Cruz, Terry Wilder, Jeffrey Garrett, Stephanie Skipper, Ramprasad Dandillaya, Kartik Ananth, Ian Frank, Helen Koenig, Eileen Donaghy, Debora Dunbar, Jennifer Killion, Rupal Amin, Shauna Basener, Timothy Lowry, Kevin Cannon, Mesha Chadwick, Oscar Galvez, Fausto Castillo, John Jefferies, Sandy Arnold, Amber Thacker, Edward Cordasco, Brian Zeno, Heather Holmes, Heather Lee, Natalia Gaibu, Victor Cojocaru, Aristia Seremet, Sergiu Iacob, Rodica Usatii, Nelea Ghicavii, Angela Coltuclu, Oxana Bujor, Eleftherios Mylonakis, Dimitrios Farmakiotis, Karen Tashima, Natasha Ryback, Peter Ruane, Peter Wolfe, Kenny Trinidad, James Moy, Raj Shah, Bandi Sindhura, Beverly Sha, Mark Savant, Francis Hsiao, Edna Yee, Manuel Gordillo, Rishi Bhattacharyya, Sudha Tallapragada, Annette Artau, Julie Larkin, Roberto Mercado, Michael Milam, Natan Kraitman, Michael Lowry, Sarah Temple, Lenka Offner, Rabih Loutfi, Kirk Voelker, Marshall Frank, Ashley Grant, James Sims, Manuel Vasquez, Kenneth Degazon, Katherine Asuncion, Jason Andrews, Aruna Subramanian, Upinder Singh, Yvonne Maldonado, Chaitan Khosla, Esteban Olivera, Mayra Abreu, Adil Fatakia, Marissa Miller, Kristen Clinton, Gary Reiss, Srilatha Edupuganti, Nadine Rouphael, Colleen Kelley, Varun Phadke, Cassie Grimsley Ackerley, Matthew Collins, Loren Miller, Timothy Hatlen, Michael Chung, Valeria Cantos Lucio, Carlos del Rio, Jeffrey Lennox, Sheetal Kandiah, Caitlin Moran, Anandi Sheth, Paulina Rebolledo, Nithin Gopalsamy, Divya Bhamidipati, Olayemi Osiyemi, Jose A. Menajovsky-Chaves, Christina Campbell, Andrew Strand, Andreas Klein, Debra Poutsiaka, Roberto Viau Colindres, Brian Chow, Cheleste Thorpe, Mary Hopkins, Jenn Chow, Rakhi Kohli, Jose Caro, Jeffrey Griffiths, Helen Boucher, Whitney Perry, Laura Kogelman, Yoav Golan, Tine Vindenes, Carlos Mendoza, Saba Mostafavi, Christhian Alejandro Cano Guerra, Paula Dabenigno, Bipin Malla, Dahlene Fusco, Arnaud Drouin, Joshua Denson, Jerry Zifodya, Christine Bojanowski, Monika Dietrich, Stacy Drury, Jesica Herrick, Richard Novak, Mahesh Patel, Gerard Acloque, Agustin Martinez, Sanjay Sethi, Brian Clemency, Rajesh Kunadharaju, Sairam Parthasarathy, Franz Rischard, Stuart Cohen, George Thompson, Hien Nguyen, Scott Crabtree, Carl Fichtenbaum, Moises Huaman, Jaime Robertson, Eric A. F. Simões, Thomas Campbell, Poornima Ramanan, Hillary Dunlevy, Esther Benamu, Amiran Baduashvili, Martin Krsak, Steven Johnson, Lakshmi Chauhan, Erica Fredregil, Samantha Economos, Brian T. Montague, Rowena Crow, Gary Kleiner, Lilian Abbo, Bhavarth Shukla, Jennifer Gebbia, Maria Rodriguez, Anne-Marie Leuck, Mahsa Abassi, Matthew Pullen, Jose Lucar Lloveras, Leandro Mena, Luis Shimose Ciudad, Jessica Lin, David Wohl, William Fischer, Kathleen Tompkins, Kami Kim, Seetha Lakshmi, Charurut Somboonwit, Jason Wilson, Asa Oxner, Tiffany Vasey, Lucy Guerra, William Petri, Katie Dykstra, Marianne Morrissey, Lejla Cesko, Jae Shin, Cirle Warren, Jennifer Sasson, Chelsea Marie, Debbie-Ann Shirley, Rebecca Carpenter, Gregory Madden, Danielle Donigan, Michelle Sutton, Cynthia Edwards, Elizabeth Brooks, Rebecca Wade, Samantha Simmons, Jennifer Pinnata, Shelly Karuna, Ann C. Collier, Julie McElrath, Janine Maenza, Adrienne Shapiro, Helen Stankiewicz-Karita, Helen Chu, Chandler Church, William Hartman, Joseph Connor, Robert Striker, Julie Philley, Megan Devine, Richard Yates, Steven Hickerson, Spyros Kalams, Greg Wilson, Michael Donnenberg, Marjolein de Wit, David Erb, Luis DeLaCruz, Supinder Channa, Sarah Henn, Megan Coleman, Lynsay MacLaren, Deborah Goldstein, Alice Eggleston, Carrington Koebele, Mark McKenzie, Teresa Deese, Benjamin Thomas, Laura Tsakiris, Stephen Blank, Ronald Mirenda, Anna Martin, Gargi Gharat, Candace Kokaram, Ket Wray, Clement Partap, Ulyana Arzamasova, Kristina Louissaint, Maria Fernandez, Achint Chani, Adebiyi Adepoju, Aisha Mortagy, Ajla Dupljak, Alison Brown, Amy Froment, Andrea Margiotta, Andrew Bombardier, Anita Islam, Anne Smith, Arvinder Dhillon, Audra McMillian, Aurora Breazna, Ayesha Aslam, Barabara Carpentino, Barry Siliverstein, Benjamin Horel, Bo Zhu, Brian Bush, Brian Head, Brian Snow, Bryan Zhu, Camille Debray, Careta Phillips, Carmella Simiele, Carol Lee, Carolyn Nienstedt, Caryn Trbovic, Catherine Elliott, Chad Fish, Charlie Ni, Christa Polidori, Christine Enciso, Christopher Caira, Christopher Powell, Cliff Baum, Colin McDonald, Cynthia Leigh, Cynthia Pan, Dana Wolken, Danielle Manganello, David Liu, David Stein, Dawlat Hassan, Daya Gulabani, Deborah Fix, Deborah Leonard, Deepshree Sarda, Denise Bonhomme, Denise Kennedy, Devin Darcy, Dhanalakshmi Barron, Diana Hughes, Diana Rofail, Dipinder Kaur, Dona Bianco, Donna Cohen, Edward Jean-Baptiste, Ehsan Bukhari, Eileen Doyle, Elizabeth Bucknam, Emily Labriola-Tomkins, Emily Nanna, Esther Huffman O'Keefe, Evelyn Gasparino, Evonne Fung, Fung-Yee To, Georgia Bellingham, Giane Sumner, Grainne Moggan, Grainne Power, Haixia Zeng, Hazel Mariveles, Heath Gonzalez, Helen Kang, Hibo Noor, Ian Minns, Izabella Peszek, James Donohue, Jamie Rusconi, Janice Austin, Janie Parrino, Jeannie Yo, Jenna McDonnell, Jessica Boarder, Jianguo Wei, Jingchun Yu, Joanne Malia, Joanne Tucciarone, Jodie Tyler-Gale, John Strein, Jonathan Cohen, Jonathan Meyer, Jordan Ursino, Joseph Im, Joseph Tramaglini, Joseph Wolken, Kaitlyn Potter, Kaitlyn Scacalossi, Kamala Naidu, Karen Browning, Karen Rutkowski, Karen Yau, Katherine Woloshin, Kelly Lewis-Amezcua, Kimberly Dornheim, Kit Chiu, Kosalai Mohan, Kristina McGuire, Kristy Macci, Kurt Ringleben, Kusha Mohammadi, Kyle Foster, Latora Knighton, Lindsay Darling, Lisa Boersma, Lisa Cowen, Lisa Hersh, Lisa Jackson, Lisa Sherpinsky, Livia Lai, Lori Faria, Lori Geissler, Louise Boppert, Lyra Fiske, Marc Dickens, Marco Mancini, Maria C. Leigh, Michael Batchelder, Michael Klinger, Michael Partridge, Michel Tarabocchia, Michelle Wong, Mivianisse Rodriguez, Moetaz Albizem, Muriel O'Byrne, Nicole Deitz, Nicole Memblatt, Nirav Shah, Nitin Kumar, Olga Herrera, Oluchi Adedoyin, Ori Yellin, Pamela Snodgrass, Patrick Floody, Paul D'Ambrosio, Paul (Xiaobang) Gao, Philippa Hearld, Qin Li, Rachel Kitchenoff, Rakiyya Ali, Ramya Iyer, Ravikanth Chava, Rinol Alaj, Rita Pedraza, Robert Hamlin, Romana Hosain, Ruchin Gorawala, Ryan White, Ryan Yu, Rylee Fogarty, S. Balachandra Dass, Sagarika Bollini, Samit Ganguly, Sandra DeCicco, Sanket Patel, Sarah Cassimaty, Selin Somersan-Karakaya, Shane McCarthy, Sharon Henkel, Shazia Ali, Shelley Geila Shapiro, Somang Kim, Soraya Nossoughi, Stephanie Bisulco, Steven Elkin, Steven Long, Sumathi Sivapalasingam, Susan Irvin, Susan Wilt, Tami Min, Tatiana Constant, Theresa Devins, Thomas Norton, Travis Bernardo, Tzu-Chien Chuang, Victor (Jianguo) Wei, Vinh Nuce, Vishnu Battini, Wilson Caldwell, Xiaobang Gao, Xin Chen, Yanmei Tian, Yasmin Khan, Yuming Zhao, Bonnie Dye, David Burns, Meredith Clement, Nirupama Sista, Sheryl Zwerski
Journal: JAMA (2022)

Easy-to-administer anti-SARS-CoV-2 treatments may be used to prevent progression from asymptomatic infection to symptomatic disease and to reduce viral carriage.