tbuckley/cabot-search huggingface dataset:
Spatio-temporal deep learning for automatic detection of intracranial vessel perforation in digital subtraction angiography during endovascular thrombectomy
Authors: Ruisheng Su, Matthijs van der Sluijs, Sandra A.P. Cornelissen, Geert Lycklama, Jeannette Hofmeijer, Charles B.L.M. Majoie, Pieter Jan van Doormaal, Adriaan C.G.M. van Es, Danny Ruijters, Wiro J. Niessen, Aad van der Lugt, Theo van Walsum
Journal: Medical Image Analysis (2022)

Intracranial vessel perforation is a peri-procedural complication during endovascular therapy (EVT). Prompt recognition is important as its occurrence is strongly associated with unfavorable treatment outcomes. However, perforations can be hard to detect because they are rare, can be subtle, and the interventionalist is working under time pressure and focused on treatment of vessel occlusions. Automatic detection holds potential to improve rapid identification of intracranial vessel perforation. In this work, we present the first study on automated perforation detection and localization on X-ray digital subtraction angiography (DSA) image series. We adapt several state-of-the-art single-frame detectors and further propose temporal modules to learn the progressive dynamics of contrast extravasation. Application-tailored loss function and post-processing techniques are designed. We train and validate various automated methods using two national multi-center datasets (i.e., MR CLEAN Registry and MR CLEAN-NoIV Trial), and one international multi-trial dataset (i.e., the HERMES collaboration). With ten-fold cross-validation, the proposed methods achieve an area under the curve (AUC) of the receiver operating characteristic of 0.93 in terms of series level perforation classification. Perforation localization precision and recall reach 0.83 and 0.70 respectively. Furthermore, we demonstrate that the proposed automatic solutions perform at similar level as an expert radiologist.
Drug therapy for heart failure with reduced ejection fraction: what is the ‘right’ dose?
Authors: Toru Kondo, Pardeep S. Jhund, John J.V. McMurray
Journal: European Journal of Heart Failure (2022)

ABSTRACT New guidelines have emphasized the primacy of starting the four key life‐saving therapies for patients with heart failure and reduced ejection fraction as quickly as possible, with titration to ‘target dose’ of these, as secondary consideration. In this article, we examine the reasons for this change in emphasis and revisit the evidence regarding the dosing of pharmacological therapy in heart failure. We demonstrate the early benefits obtained with even low doses of most of the foundational therapies for heart failure and reduced ejection fraction. We also clarify that the ‘target dose’ of those therapies requiring titration was a goal based on tolerability and often not reached in trials, i.e. the proven benefits of our foundational therapies were demonstrated with an average dose that was less than target and many patients in these trials were treated with sub‐target doses.
Molecular Pathways: Targeting ETS Gene Fusions in Cancer
Authors: Felix Y. Feng, J. Chad Brenner, Maha Hussain, Arul M. Chinnaiyan
Journal: Clinical Cancer Research (2014)

Rearrangements, or gene fusions, involving the ETS family of transcription factors are common driving events in both prostate cancer and Ewing sarcoma. These rearrangements result in pathogenic expression of the ETS genes and trigger activation of transcriptional programs enriched for invasion and other oncogenic features. Although ETS gene fusions represent intriguing therapeutic targets, transcription factors, such as those comprising the ETS family, have been notoriously difficult to target. Recently, preclinical studies have demonstrated an association between ETS gene fusions and components of the DNA damage response pathway, such as PARP1, the catalytic subunit of DNA protein kinase (DNAPK), and histone deactylase 1 (HDAC1), and have suggested that ETS fusions may confer sensitivity to inhibitors of these DNA repair proteins. In this review, we discuss the role of ETS fusions in cancer, the preclinical rationale for targeting ETS fusions with inhibitors of PARP1, DNAPK, and HDAC1, as well as ongoing clinical trials targeting ETS gene fusions.
Tackling the politics of intersectoral action for the health of people and planet
Authors: Kent Buse, Göran Tomson, Shyama Kuruvilla, Jemilah Mahmood, Anastasia Alden, Maarinke van der Meulen, Ole Petter Ottersen, Andy Haines
Journal: BMJ (2022)

Kent Buse and colleagues argue that unlocking the potential for intersectoral action on climate and health requires thinking politically about its facilitators and barriers Human activities are wreaking extensive damage on the natural systems of the planet and undermining the prospects for the health of current and future populations. The 2021 report of the Intergovernmental Panel on Climate Change provided further evidence of the increasing urgency of responding to the threats posed by climate change—which the UN secretary general labelled "a code red for humanity."12 The UN climate conference in Glasgow (COP26) laid bare the highly political nature of international cooperation on climate change, and the futility of failing to recognise that the health and sustainability of the environment are the cornerstone of equitable development.34 The politics inherent in intersectoral action on climate and health may be less visible than COP26 but must be addressed to deliver the goals of the Paris agreement (box 1).7 Box 1 ### Climate emergency imperative for intersectoral action56RETURN TO TEXT
Marriages
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Performance of AFP, AFP-3, DCP as Biomarkers for Detection of Hepatocellular Carcinoma (HCC): A Phase 3 Biomarker Study in the United States
Authors: Nabihah Tayob, Fasiha Kanwal, Abeer Alsarraj, Ruben Hernaez, Hashem B. El-Serag
Journal: Clinical Gastroenterology and Hepatology (2022)
Targeted downregulation of HIF-1α for restraining circulating tumor microemboli mediated metastasis
Authors: Junjie Du, Cong Wang, Yijun Chen, Lingyu Zhong, Xuwentai Liu, Lingjing Xue, Ying Zhang, Yanyi Li, Xiaoyu Li, Chunming Tang, Zhigui Su, Can Zhang
Journal: Journal of Controlled Release (2022)
Bioactive Poly(octanediol‐citrate‐polyglycol) Accelerates Skin Regeneration through M2 Polarization Immunomodulating and Early Angiogenesis
Authors: Chenxi Xie, Meng Luo, Mi Chen, Min Wang, Xiaoyan Qu, Bo Lei
Journal: Advanced Healthcare Materials (2022)

Abstract The inhibition of inflammation and the promotion of early angiogenesis are paid much attention in skin tissue engineering. Citric acid‐based biomaterials are widely used in tissue engineering due to their bioactive structure and biocompatibility, but there are few studies on investigating their role and mechanism in wound repair and skin regeneration. Herein, the potential anti‐inflammation mechanism of poly(octanediol‐citrate‐polyglycol) (POCG) copolymer is reported in regulating skin wound repair. It is found that POCG can modulate macrophages phenotype through downregulating the expression of proinflammatory cytokines (tumor necrosis facor‐α ( Tnf‐α ), Interleukin‐1β ( IL‐1β ), and Interleukin‐6 ( IL‐6 ) and polarizing macrophages to anti‐inflammatory (M2) phenotype. POCG can promote endothelial cell vascularization by increasing the expression of angiogenesis factors (vascular endothelial growth factor ( Vegf ) and cluster of differentiation 31CD31) mediated by the macrophage polarization. The in vivo study shows that POCG can accelerate skin wound repair through suppressing the acute inflammation and inducing early angiogenesis through the polarization modulation. Furthermore, the POCG polymer has good biocompatibility for both immune cells and tissue cells. This study may provide the important theoretical support on the bioactivity of citrate‐based biomaterials and expanding their applications in tissue engineering.
Progress of Yellow Fever.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Exploring the Effects of BMI, Dose, and Route of Administration on Efficacy of Immunoglobulin G Replacement Therapy
Authors: Nikki Kimura, Miriam Samstein, Brianne Navetta-Modrov, David Rosenthal, Blanka Kaplan, Vincent Bonagura, Artemio Jongco
Journal: Journal of Allergy and Clinical Immunology (2022)
CD38+ B cells affect immunotherapy for allergic rhinitis
Authors: Gui-Xiang Tian, Ke-Ping Peng, Ming-Hui Liu, Dao-Fa Tian, Hai-Qing Xie, Li-Wen Wang, Yu-Yang Guo, Shan Zhou, Li-Hua Mo, Ping-Chang Yang
Journal: Journal of Allergy and Clinical Immunology (2022)
Indoor Dust Bacterial and Fungal Microbiome in Homes of Asthmatic Children from 5 US Cities
Authors: Dong-Binh Tran, Kathleen Lee-Sarwar, Erica Sodegren, Andrew Liu, Stanley Szefler, Scott Weiss, Steven Gill, George Weinstock, Augusto Litonjua
Journal: Journal of Allergy and Clinical Immunology (2022)
The Ureter
Authors: Anthony J. Thomas
Journal: JAMA (1982)

It has been 14 years since Dr Bergman brought out his first edition of<i>The Ureter</i>. In reading the second edition, it is obvious that Bergman and his excellent selection of authors have detailed the anatomy, physiology, and pathology sufficiently to merit calling the ureter a specific, anatomic organ rather than a simple conduit carrying urine from the kidney to the bladder. The book itself is much more extensive in its coverage and more easily read than the previous edition owing to the print and paper used. Advances in this technical respect are also seen in the markedly improved reproductions of x-ray films copiously used throughout the text. Listing specific and outstanding chapters is difficult, since there are a number of excellent monographs contained within these 700-plus pages. The chapter by Weiss denoting the effect of drugs on the ureter contains a great deal of academic and clinical interest. There
Lectures on the Diseases of Children: Delivered in the Chatham Street School of Medicine, Manchester
Authors: None Merei
Journal: BMJ (1852)

Fevers in their objective appearance in infants and children under three years; their more alarming aspect;, relation of different ages, to different kinds of fevers.The principal symptoms and their compara- tive analysis.The whole objective description of a primary paroxysm.Comparative and synthetic procedure in forming our opinion on a recently- developedfever; prudent reserve of the practitioner; changes to be expected within the first thirty-six hours.GENTLEMEN,.-Having in the former series of lectures exposed what I would call preliminary notions, I come now to speak on special diseases.I intend, before all, to devote a few lectures to fevers in infants and young children, considered as they appear to your senses, by objective symptoms, without the aid of words on the part of the patient, and how to manage them accordingly.My inquiries will almost entirely refer to the tender age under three years, because in proportion to the advancing age, all kinds of peculiarities in form, diagnosis and treatment, and all kinds of difficulties become less.In this task I have no predecessors, and you will find nothing of the kind in books; but I am convinced of its usefulness and of the possibility of giving the young practitioner some valuable hints and directions.Fevers in children form a most arduous part of practice.You will have occasion to notice constantly, that as soon as a child shows the expressive symptoms of fever, the parents get uncommonly afraid and excited, and the position of the physician becomes a very diffi- cult one.The reason of this is dear.It is the greater vehemence and obscurity of symptoms.Bethink your- self of two patients affected with the same kind and degree of fever; the one a man and the other an infant.On both you observe, without asking, a high degree of beat, great frequency of the pulse, both with great languor on their countenance, heavily moaning, and refusing food.You auscultate both, and find nothing important in the chest.So far you are on equal diagnostical terms with the man and the infant; but you-feel not satisfied.That expression of languor and that moaning make you anxious, and you will now ask some questions.The man answers :-he feels no decided pain anywhere, but giddiness and heavy pressure in his forehead, fulness and pressure in the epigastrium, and bitter taste in the mouth.And now you feel satis- fied and easy about the patient; you prescribe an
JAMA reference directories
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Sudden infant death syndrome
Authors: Kevin Reynard, John Gosnold, Paul Grout
Journal: BMJ (1993)

We hope that this extension ofour assessment of the senior house officers in our department proves to be both useful and acceptable to them.The main drawback to this form of assessment is that it is labour intensive, requiring the synchronous participation of both the junior and senior doctors of the department.This programme of assessment is being extended to include other hospitals in our region.Towards the end of this year we hope to report our experiences after assessing the training of further groups of senior house officers working in our department.
State Boards of Registration
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Do Mast Cells Reduce Response to Proton Pump Inhibitors in Pediatric Eosinophilic Esophagitis?
Authors: Paroma Bose, Katrina Collins, Djamilatou Adom, Pegah Mehrpouya-Bahrami, Anthony Perkins, Sandeep Gupta, Emily Hon, Mark Kaplan
Journal: Journal of Allergy and Clinical Immunology (2022)
SUMMARIOS IN INTERLINGUA
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MOTOR NOTES FOR MEDICAL MEN
Authors: H. M. Buist
Journal: BMJ (1914)

oz'L nloin-pregnant than in pregnant womiien, and lhe tlhought tlhat it should not be operated on, as life vas not thereby prolonged.The discharge froml the nipple gave valuable evidence as to the nature of the growth; a dark, san- guineous or granular discharge pointed to carcinoma; pure blood was almost diagnostic of papillary cystadenoma, but it must be remembered that the latter tumlours had a marked tendency to become malignant.Cutting into a growtlh was the direct cause of imme- diate dissemination, so that a piece of the tumour should
The Neutrophil Lymphocyte Ratio (NLR); recycled as Predictor of Angiographic Coronary Artery Disease Severity in stable Ischaemic Heart Disease
Authors: Attia Mustafa, Mohamed Daoub
Journal: Clinical Cardiology and Cardiovascular Interventions (2022)

Background: The Neutrophil lymphocyte ratio (NLR) is historically well established in predicting inflammatory process and severity, including atherosclerotic disease. We explore the NLR and how it relates to angiographic coronary artery disease (CAD) severity in patients with stable ischemic heart disease (SIHD). Materials and Methods: We identified 714 patients with SIHD from the local database of Benghazi Medical Centre (BMC) between Jan 2019-June 2020. Exclusion criteria included patients with acute coronary syndromes (ACS), surgical revascularization, moderate-severe left ventricle systolic dysfunction (LVSD) with Ejection fraction less than 45% or New York Heart Association (NYHA) class III-IV. We also excluded patients with significant co-morbidities including chronic kidney disease with glomerular filtration rate (GFR &lt;30), liver cirrhosis, cancer and systemic inflammation requiring long-term steroid therapy. We present a retrospective, cross-sectional study of 427 patients with known SIHD, we explored the relationship between the NLR and the angiographic severity of CAD, using the Gensini score (GS). The association was assessed using correlation analysis and bivariate logistical regression. Results: Patients were categorized into two groups according to the GS, a mild-moderate group (n=178; 41.7%) and a severe group (n=249; 58.3%). A baseline NLR was measured by dividing the Neutrophil count over the Lymphocyte count. In the first group of mild-moderate GS, 160 (89.9%) had an NLR within normal range and 18 (10.1%) demonstrated a high NLR value. However, in the severe GS group 17 (6.8%) showed a normal NLR and 232 (93.2%) demonstrated a high NLR (CI 95%, p=0.0001). Moreover, the distribution of severe GS CAD had a statistically significant overlap with diabetes being the number one risk factor (p=0.0001) when compared to age above 50 (p=0.024). Conclusion: NLR is a valuable independent predictor of the severity of CAD and seems to be a reliable indicator for cardiac risk stratification in patients with SIHD, therefore can potentially be added as a prioritization tool for cardiac angiography.
Electrophysiologic and electroanatomic characterization of the atria in sinus node disease: Evidence of diffuse atrial remodeling
Authors: Prashanthan Sanders, Joseph B. Morton, Peter M. Kistler, Neil C. Davidson, Azlan Hussin, Steven J. Spence, Catherine B. Lindsay, Jitendra K. Vohra, Paul B. Sparks, Jonathan M. Kalman
Journal: Journal of the American College of Cardiology (2003)
Unilateral hypacusis and facial swelling
Authors: S. P. Kadish
Journal: JAMA (1971)

Dr. Robert A. Novelline: This 63-year-old white woman was admitted to the Massachusetts Eye and Ear Infirmary because of painless swelling of the left eyelids and left cheek of 1 1/2 years' duration. One year prior to admission, she noted decreased auditory acuity on the left side. The auditory symptoms and edema responded to a course of corticosteroids. Physical examination revealed these findings on the left side: marked edema of the lower eyelid, slight swelling of the upper lid, slight proptosis, a mass in the upper part of the buccogingival area, and swelling of the cheek. Nasopharyngoscopy showed swelling of the orifice of the left eustachian tube and a smooth, bulging mass in the left vault of the nasopharynx. The left maxillary antrum transilluminated poorly. No lymph nodes were palpable in the neck. Roentgenograms of the paranasal sinuses and skull were obtained. <h3>Discussion</h3> Dr. Paul F. J. New: In the