tbuckley/cabot-search huggingface dataset:
Complete polyp resection with cold snare versus hot snare polypectomy for polyps of 4–9 mm: a randomized controlled trial
Authors: Ina B. Pedersen, Anna Rawa-Golebiewska, Audrey H. Calderwood, Lone D. Brix, Louise B. Grode, Edoardo Botteri, Marek Bugajski, Michal F. Kaminski, Wladyslaw Januszewicz, Hjalmar Ødegaard, Britta Kleist, Mette Kalager, Magnus Løberg, Michael Bretthauer, Geir Hoff, Asle Medhus, Øyvind Holme
Journal: Endoscopy (2022)

Background Endoscopic screening with polypectomy reduces the incidence of colorectal cancer (CRC). Incomplete polyp removal may attenuate the effect of screening. This randomized trial compared cold snare polypectomy (CSP) with hot snare polypectomy (HSP) in terms of complete polyp resection. Methods We included patients ≥ 40 years of age at eight hospitals in four countries who had at least one non-pedunculated polyp of 4–9 mm detected at colonoscopy. Patients were randomized 1:1 to CSP or HSP. Biopsies from the resection margins were obtained systematically after polypectomy in both groups. We hypothesized that CSP would be non-inferior to HSP, with a non-inferiority margin of 5 %. Logistic regression models were fitted to identify the factors explaining incomplete resection. Results 425 patients, with 601 polyps, randomized to either CSP or HSP were included in the analysis. Of 318 polyps removed by CSP and 283 polyps removed by HSP, 34 (10.7 %) and 21 (7.4 %) were incompletely resected, respectively, with an adjusted risk difference of 3.2 % (95 %CI −1.4 % to 7.8 %). There was no difference between the groups in terms of post-polypectomy bleeding, perforation, or abdominal pain. Independent risk factors for incomplete removal were serrated histology (odds ratio [OR] 3.96; 95 %CI 1.63 to 9.66) and hyperplastic histology (OR 2.52; 95 %CI 1.30 to 4.86) in adjusted analyses. Conclusion In this randomized trial, non-inferiority for CSP could not be demonstrated. Polyps with serrated histology are more prone to incomplete resection compared with adenomas. CSP can be used safely for small polyps in routine colonoscopy practice.
TCT-660 Nine-year Clinical Outcomes After The First Sirolimus-eluting Stent Implantation: Impact Of In-stent Restenosis Lesion
Authors: Hiroshi Miyawaki, Kazushige Kadota, Takeshi Tada, Shunsuke Kubo, Seiji Habara, Hiroyuki Tanaka, Tsuyoshi Goto, Kazuaki Mitsudo
Journal: Journal of the American College of Cardiology (2014)
Photodynamic therapy for preinvasive vaginal cancer.
Authors: Viktoria A. Ivanova, Ekaterina V. Verenikina, Vera P. Nikitina, Oksana E. Zhenilo, Anna Yu. Ardzha
Journal: Journal of Clinical Oncology (2021)

5592 Background: Photodynamic therapy (PDT) is an effective method for the treatment of various cancers resulting in apoptosis, autophagy and ischemic necrosis of irradiated tissues. The purpose of the study was to analyze the efficacy of PDT for pre-invasive vaginal cancer treatment. Methods: PDT results were studied in 20 patients aged 32-65 years with verified pre-invasive vaginal cancer. All patients received PDT with the Latus diode laser and Photolon or Photolan photosensitizers. The effect was evaluated with extended colposcopy. The criteria for efficiency included normalization of the colposcopic picture and the absence of atypical cells. The sizes of the irradiation fields varied from 1.5 to 2 cm, the number of fields - from 1 to 4, the power density - from 0.1 to 0.17 W/cm2, the light dose - from 40 to 100 J/cm2. The duration of a PDT session varied from 10 to 30 min, depending on the number of irradiation fields. The irradiation field necessarily included an area of normal tissue 3-5 mm surrounding the lesion. 4 to 6 sessions were required to restore the normal layer of stratified squamous epithelium. The antitumor efficacy of PDT was evaluated based on the results of visual observation of changes in the area of the treated pathological foci and information on the presence or absence of clinical symptoms of the disease 1 and 3 months after the treatment (WHO criteria). Results: Complete regression was registered in 100% of patients after 3 months. Repeated courses of PDT were required in cases with a wide spread of pathological foci and the impossibility of their simultaneous irradiation. At follow-up after 1 month, 3 of 20 patients (15%) showed local foci of atypical changes in the epithelium managed with repeated PDT courses. In 6 months, stable remission of the disease clinical symptoms in the treated pathological foci was registered. The results of the cytological study performed 3 months after PDT were normal in 100% patients; no negative changes were registered 6 and 12 months after PDT. Conclusions: The results of PDT in the treatment of patients with pre-invasive vaginal cancer demonstrated its high therapeutic efficacy and a minimal number of adverse reactions, which allows recommending PDT in the treatment of pre-invasive vaginal cancer.
Exuberant Verbosity
Authors: Bernard Wolff
Journal: JAMA (1913)

<h3>To the Editor:</h3> —Has the editorial writer (The Journal, Oct. 18, 1913, p. 1464) overlooked the historical fact that the exuberant verbosity of legal forms was not an intoxication, but a species of graft? Old English law-clerks were paid so much a word or a line for engrossing legal documents, and in consequence the more words used, the greater the pay. Every synonym, nearly or distantly connected, was drawn in and duly inscribed. A sentence lingers in my memory, taken from an old English common-law form of indictment for maintaining a nuisance in which it is alleged that "divers odors, savors, smells, scents and stenches did issue, proceed and flow therefrom." As the principles of<i>lex scripta</i>are said to be immutable, so also appears to be its language; for the same quaint, archaic phraseology, scarcely altered except in spelling, is used in legal forms to-day as in the days
Textbook of Pediatric Intensive Care
Authors: Alan I. Fields
Journal: JAMA (1987)

Several textbooks have been written on critical care medicine, with pediatrics occupying but a small part. The knowledge base and practice of pediatric critical care medicine as a separate entity have been only superficially covered, despite the fact that it has its own certification process through the American Board of Pediatrics. Now, the<i>Textbook of Pediatric Intensive Care</i>, written by members of the Department of Anesthesiology/Critical Care Medicine of the Johns Hopkins Hospital and edited by Mark Rogers, MD, has attempted to answer this growing need. This textbook contains two volumes whose chapters generally reflect an organ systems approach. Volume 1 has four sections with 24 chapters covering the cardiac (including cardiopulmonary resuscitation), respiratory, and neurological systems. Volume 2 has six sections with 18 chapters and covers the other organ systems and miscellaneous topics, including nursing and psychosocial and financial issues. Each chapter is preceded by a complete table of
Multiscale Anisotropic Tissue Biofabrication via Bulk Acoustic Patterning of Cells and Functional Additives in Hybrid Bioinks
Authors: Parth Chansoria, Suleman Asif, Nithin Gupta, Jorge Piedrahita, Rohan A. Shirwaiker
Journal: Advanced Healthcare Materials (2022)

Recapitulation of the microstructural organization of cellular and extracellular components found in natural tissues is an important but challenging feat for tissue engineering, which demands innovation across both process and material fronts. In this work, a highly versatile ultrasound-assisted biofabrication (UAB) approach is demonstrated that utilizes radiation forces generated by superimposing ultrasonic bulk acoustic waves to rapidly organize arrays of cells and other biomaterial additives within single and multilayered hydrogel constructs. UAB is used in conjunction with a novel hybrid bioink system, comprising of cartilage-forming cells (human adipose-derived stem cells or chondrocytes) and additives to promote cell adhesion (collagen microaggregates or polycaprolactone microfibers) encapsulated within gelatin methacryloyl (GelMA) hydrogels, to fabricate cartilaginous tissue constructs featuring bulk anisotropy. The hybrid matrices fabricated under the appropriate synergistic thermo-reversible and photocrosslinking conditions demonstrate enhanced mechanical stiffness, stretchability, strength, construct shape fidelity and aligned encapsulated cell morphology and collagen II secretion in long-term culture. Hybridization of UAB is also shown with extrusion and stereolithography printing to fabricate constructs featuring 3D perfusable channels for vasculature combined with a crisscross or circumferential organization of cells and adhesive bioadditives, which is relevant for further translation of UAB toward complex physiological-scale biomimetic tissue fabrication.
Mortality in β-thalassemia patients with confirmed pulmonary arterial hypertension on right heart catheterization
Authors: Valeria Maria Pinto, Khaled M. Musallam, Giorgio Derchi, Giovanna Graziadei, Marianna Giuditta, Raffaella Origa, Susanna Barella, Gavino Casu, Annamaria Pasanisi, Filomena Longo, Maddalena Casale, Roberta Miceli, Pierluigi Merella, Immacolata Tartaglione, Antonio Piga, Maria Domenica Cappellini, Barbara Gianesin, Gian Luca Forni
Journal: Blood (2022)
Consistent effects of growth hormone on LV function in early and advanced stage of heart failure in cardiomyopathic hamsters Takao Nishizawa, Mitsunori Iwase, Hiroaki Kanazawa, Tetsuro Nagasaka, Takaaki Hasegawa, Ryoji Ishiki, Fuji Somura, Hideo Izawa, Yoshihiro Ishikawa, Mitsuhiro Yokota. Nagoya University, Nagoya, Japan
Journal: Journal of the American College of Cardiology (2001)
One Wire or two? The value of electrophysiologic testing to guide selection of single versus dual chamber defibrillators Jay H. Curwin, Robert F. Coyne, William Wesloske, Karen Quinlan, Etti Eckstein, Kelly Shea, Elizabeth Tuffiash, John S. Banas, Jr., Stephen L. Winters. Morristown Memorial Hospital, Morristown, NJ
Journal: Journal of the American College of Cardiology (2001)
Gheel Revisited
Authors: Charles D. Aring
Journal: JAMA (1974)

... —even I Regained my freedom with a sigh. —<i>The Prisoner of Chillon</i> LORD Byron, keen observer of the social scene, whose humor generally was kept in good repair, averred that it would have made little difference early in the nineteenth century if those in institutions for the insane were out, and those out, in. His point is well taken. The most recent move to release long-term mental patients from state hospitals was heralded in 1958, when Dr. Harry Solomon, then President of the American Psychiatric Association, said: I do not see how any reasonably objective view of our mental hospitals today can fail to conclude that they are bankrupt beyond remedy. I believe, therefore, that our large mental hospitals should be liquidated as rapidly as can be done in an orderly and progressive fashion. The mental hospitals in some of the larger states have implemented programs for the phasing
Prognostic Impact of Extra–Mitral Valve Cardiac Involvement in Patients With Primary Mitral Regurgitation
Authors: Aniek L. van Wijngaarden, Valentina Mantegazza, Yasmine L. Hiemstra, Valentina Volpato, Pieter van der Bijl, Mauro Pepi, Meindert Palmen, Victoria Delgado, Nina Ajmone Marsan, Gloria Tamborini, Jeroen J. Bax
Journal: JACC. Cardiovascular imaging (2022)
Contents
Authors: D Drossman, J Ruddy, J Anderson, R Yadlapati, D Katzka, N Noor, S Goh, C Tan, S Picardo, K Koro, C Seow, G Cohen, J Ong, C Swift, Y Al-Naeeb, Y Okagawa, T Sumiyoshi, H Kondo, F Marcellin, V Beo, P Carrieri, Reply Long, T Naimi
Journal: Clinical Gastroenterology and Hepatology (2020)
OSTEOPATHY.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ASSOCIATIONS OF HOSPITAL STRATEGIES AND 30-DAY RISK-STANDARDIZED MORTALITY RATES IN PERCUTANEOUS CORONARY INTERVENTION
Authors: Jeptha Curtis, Karl E. Minges, Jeph Herrin, Nihar Desai, Brahmajee Nallamothu, John Rumsfeld, Mary Anne Elma, Peggy Chen, Henry Ting, John Messenger
Journal: Journal of the American College of Cardiology (2016)
The Lysine Acetyltransferase Tip60 Is Required for Hematopoietic Stem Cell Maintenance
Authors: Akihiko Numata, Hui Si Kwok, Qi-Ling Zhou, Jia Li, Rebecca Hannah, Jihye Park, Vladimir Espinosa Angarcia, Berthold Gottgens, Henry Yang, John Lough, Deepak Bararia, Daniel G. Tenen
Journal: Blood (2018)
Umbilical cord prolapse.
Journal: BMJ (1978)

intra-articular injections of steroids have an important place in the overall management of patients suffering from both types of chronic arthritis.These injections should not, however, be given in a predetermined course of treatment; and the interval between injections should not be less than four weeks.Before any repeat injection is given, the doctor should carefully appraise the effect achieved and the state of the oint.Clinicians following this balanced advice will do much good to their reputation and little harm to the patient.The case for local corticosteroid injections in rheumatoid arthritis is well substantiated.In osteoarthrosis a more rational approach may be to infiltrate tender areas around the joint intralesionally, unless there is an obvious reactive synovitis secondary to the degenerative condition, when intra-articular *therapy may help.
A minimal monitoring approach for the treatment of hepatitis C virus infection (ACTG A5360 [MINMON]): a phase 4, open-label, single-arm trial
Authors: Sunil S Solomon, Sandra Wagner-Cardoso, Laura Smeaton, Leonard A Sowah, Chanelle Wimbish, Gregory Robbins, Irena Brates, Christine Scello, Annie Son, Anchalee Avihingsanon, Benjamin Linas, Donald Anthony, Estevão Portela Nunes, Dimas A Kliemann, Khuanchai Supparatpinyo, Cissy Kityo, Pablo Tebas, Jaclyn Ann Bennet, Jorge Santana-Bagur, Constance A Benson, Marije Van Schalkwyk, Nelson Cheinquer, Susanna Naggie, David Wyles, Mark Sulkowski
Journal: The Lancet. Gastroenterology & hepatology (2022)
THE DOMESTIC ANIMALS AND CONTAGIOUS DISEASES.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A novel imatinib-upregulated long noncoding RNA plays a critical role in inhibition of tumor growth induced by Abl oncogenes
Authors: Yun Ma, Guijie Guo, Tingting Li, Faxin Wen, Jianling Yang, Biao Chen, Xuefei Wang, Ji-Long Chen
Journal: Molecular Cancer (2022)

Abstract Background Dysregulation of long noncoding RNAs (lncRNAs) has been linked to various human cancers. Bcr-Abl oncogene that results from a reciprocal translocation between human chromosome 9 and 22, is associated with several hematological malignancies. However, the role of lncRNAs in Bcr-Abl-induced leukemia remains largely unexplored. Methods LncRNA cDNA microarray was employed to identify key lncRNAs involved in Bcr-Abl-mediated cellular transformation. Abl-transformed cell survival and xenografted tumor growth in mice were evaluated to dissect the role of imatinib-upregulated lncRNA 1 (IUR1) in Abl-induced tumorigenesis. Primary bone marrow transformation and in vivo leukemia transplant using lncRNA-IUR1 knockout (KO) mice were further conducted to address the functional relevance of lncRNA-IUR1 in Abl-mediated leukemia. Transcriptome RNA-seq and Western blotting were performed to determine the mechanisms by which lncRNA-IUR1 regulates Bcr-Abl-induced tumorigenesis. Results We identified lncRNA-IUR1 as a critical negative regulator of Bcr-Abl-induced tumorigenesis. LncRNA-IUR1 expressed in a very low level in Bcr-Abl-positive cells from chronic myeloid leukemia patients. Interestingly, it was significantly induced in Abl-positive leukemic cells treated by imatinib. Depletion of lncRNA-IUR1 promoted survival of Abl-transformed human leukemic cells in experiments in vitro and xenografted tumor growth in mice, whereas ectopic expression of lncRNA-IUR1 sensitized the cells to apoptosis and suppressed tumor growth. In concert, silencing murine lncRNA-IUR1 in Abl-transformed cells accelerated cell survival and the development of leukemia in mice. Furthermore, lncRNA-IUR1 deficient mice were generated, and we observed that knockout of murine lncRNA-IUR1 facilitated Bcr-Abl-mediated primary bone marrow transformation. Moreover, animal leukemia model revealed that lncRNA-IUR1 deficiency promoted Abl-transformed cell survival and development of leukemia in mice. Mechanistically, we demonstrated that lncRNA-IUR1 suppressed Bcr-Abl-induced tumorigenesis through negatively regulating STAT5-mediated GATA3 expression. Conclusions These findings unveil an inhibitory role of lncRNA-IUR1 in Abl-mediated cellular transformation, and provide new insights into molecular mechanisms underlying Abl-induced leukemogenesis.
A commentary on “Changes in appendicitis treatment during the COVID-19 pandemic - A systematic review and meta-analysis” [Int. J. Surg. 95 (2021) 106148]
Authors: María Manuela Rodríguez-Gutiérrez, Jorge Andrés Hurtado-Mayor, Laura Manuela Sánchez-Pinto, María Carolina Díaz-Rivera
Journal: International Journal of Surgery (2022)
Abstract 23: The Usefulness of Neuron-Specific Enolase in Cerebrospinal Fluid to Predict Neurological Prognosis in Cardiac Arrest Survivors Who Underwent Target Temperature Management: A Prospective Observational Study
Authors: Jung Soo Park
Journal: Circulation (2019)

Aim: We aimed to investigate the prognostic performance between serum NSE and cerebrospinal fluid (CSF) NSE for 6-month neurologic outcome in OHCA survivors underwent target temperature management (TTM). Hypothesis: We hypothesized that the NSE levels measured in the CSF would affect the change, earlier and more sensitively than serum, according to severity of hypoxic brain damage. Methods: This single-centre prospective observational study included out-of-hospital cardiac arrest (OHCA) patients underwent TTM. NSE levels were assessed in blood and CSF samples obtained immediately (Day 0), and 24 h (Day 1), 48 h (Day 2), and 72 h (Day 3) after return of spontaneous circulation (ROSC). The primary outcome was the 6-month neurological outcome. Results: We enrolled 34 patients (males, 24; 70.6%), 16 (47.1%) had a poor neurologic outcome. CSF NSE and serum NSE values were significantly higher in the poor outcome group compared to the good outcome group at each time point, except for serum Day 0. CSF NSE and serum NSE had area under curve (AUC) of 0.819-0.972 and 0.648-0.920, respectively. CSF NSE prognostic performances were significant higher than serum NSE at Day 1 and showed excellent AUC values (0.969; 95% Confidential Interval [CI] 0.844-0.999) and high sensitivity (93.8%; 95% CI 69.8-99.8) at 100% specificity. Conclusion: We found CSF NSE values were highly predictive and sensitive markers of 6-month poor neurological outcome in OHCA survivors treated with TTM at Day 1 after ROSC. Thus, CSF NSE level at day 1 after ROSC can be a useful early prognosticator in OHCA survivors.
COLONIES FOR EPILEPTICS.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal