tbuckley/cabot-search huggingface dataset:
Stopping Renin-Angiotensin System Inhibitors in Patients with Advanced CKD and Risk of Adverse Outcomes: A Nationwide Study
Authors: Edouard L. Fu, Marie Evans, Catherine M. Clase, Laurie A. Tomlinson, Merel van Diepen, Friedo W. Dekker, Juan J. Carrero
Journal: Journal of the American Society of Nephrology (2020)

Background It is unknown whether stopping renin-angiotensin system (RAS) inhibitor therapy in patients with advanced CKD affects outcomes. Methods We studied patients referred to nephrologist care, listed on the Swedish Renal Registry during 2007–2017, who developed advanced CKD (eGFR&lt;30 ml/min per 1.73 m 2 ) while on RAS inhibitor therapy. Using target trial emulation techniques on the basis of cloning, censoring, and weighting, we compared the risks of stopping within 6 months and remaining off treatment versus continuing RAS inhibitor therapy. These included risks of subsequent 5-year all-cause mortality, major adverse cardiovascular events, and initiation of kidney replacement therapy (KRT). Results Of 10,254 prevalent RAS inhibitor users (median age 72 years, 36% female) with new-onset eGFR &lt;30 ml/min per 1.73 m 2 , 1553 (15%) stopped RAS inhibitor therapy within 6 months. Median eGFR was 23 ml/min per 1.73 m 2 . Compared with continuing RAS inhibition, stopping this therapy was associated with a higher absolute 5-year risk of death (40.9% versus 54.5%) and major adverse cardiovascular events (47.6% versus 59.5%), but with a lower risk of KRT (36.1% versus 27.9%); these corresponded to absolute risk differences of 13.6 events per 100 patients, 11.9 events per 100 patients, and −8.3 events per 100 patients, respectively. Results were consistent whether patients stopped RAS inhibition at higher or lower eGFR, across prespecified subgroups, after adjustment and stratification for albuminuria and potassium, and when modeling RAS inhibition as a time-dependent exposure using a marginal structural model. Conclusions In this nationwide observational study of people with advanced CKD, stopping RAS inhibition was associated with higher absolute risks of mortality and major adverse cardiovascular events, but also with a lower absolute risk of initiating KRT.
Myocardial Expression Levels of Micro-Ribonucleic Acids in Patients With Left Ventricular Assist Devices: Signature of Myocardial Recovery, Signature of Reverse Remodeling, or Signature With No Name?⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Authors: Douglas L. Mann, Daniel Burkhoff
Journal: Journal of the American College of Cardiology (2011)
Whole exome HBV DNA integration is independent of the intrahepatic HBV reservoir in HBeAg-negative chronic hepatitis B
Authors: Valentina Svicher, Romina Salpini, Lorenzo Piermatteo, Luca Carioti, Arianna Battisti, Luna Colagrossi, Rossana Scutari, Matteo Surdo, Valeria Cacciafesta, Andrea Nuccitelli, Navjyot Hansi, Francesca Ceccherini Silberstein, Carlo Federico Perno, Upkar S Gill, Patrick T F Kennedy
Journal: Gut (2020)

Objective The involvement of HBV DNA integration in promoting hepatocarcinogenesis and the extent to which the intrahepatic HBV reservoir modulates liver disease progression remains poorly understood. We examined the intrahepatic HBV reservoir, the occurrence of HBV DNA integration and its impact on the hepatocyte transcriptome in hepatitis B ‘e’ antigen (HBeAg)-negative chronic hepatitis B (CHB). Design Liver tissue from 84 HBeAg-negative patients with CHB with low (n=12), moderate (n=25) and high (n=47) serum HBV DNA was analysed. Covalently closed circular DNA (cccDNA), pregenomic RNA (pgRNA) were evaluated by quantitative PCR, whole exome and transcriptome sequencing was performed by Illumina, and the burden of HBV DNA integrations was evaluated by digital droplet PCR. Results Patients with low and moderate serum HBV DNA displayed comparable intrahepatic cccDNA and pgRNA, significantly lower than in patients with high HBV DNA, while hepatitis B core-related antigen correlated strongly with the intrahepatic HBV reservoir, reflecting cccDNA quantity. Whole exome integration was detected in a significant number of patients (55.6%, 14.3% and 25% in high, moderate and low viraemic patients, respectively), at a frequency ranging from 0.5 to 157 integrations/1000 hepatocytes. Hepatitis B surface antigen &gt;5000 IU/mL predicted integration within the exome and these integrations localised in genes involved in hepatocarcinogenesis, regulation of lipid/drug metabolism and antiviral/inflammatory responses. Transcript levels of specific genes, including the proto-oncogene hRAS, were higher in patients with HBV DNA integration, supporting an underlying oncogenic risk in patients with low-level to moderate-level viraemia. Conclusions HBV DNA integration occurs across all HBeAg-negative patients with CHB, including those with a limited HBV reservoir; localising in genes involved in carcinogenesis and altering the hepatocyte transcriptome.
Mutation in KARS: A novel mechanism for severe anaphylaxis
Authors: Pau Ribó, Yanru Guo, Juan Aranda, Erola Ainsua-Enrich, Arnau Navinés-Ferrer, Mario Guerrero, Mariona Pascal, Cinthia de la Cruz, Modesto Orozco, Rosa Muñoz-Cano, Margarita Martin
Journal: Journal of Allergy and Clinical Immunology (2020)
ONC213, a Novel Second Generation Analog of ONC201, Shows Promising Anti-Leukemic Activity Against AML Cells In Vitro and In Vivo
Authors: Yongwei Su, Xinyu Li, Holly Edwards, Joshua E. Allen, Martin Stogniew, Varun Vijay Prabhu, Jeffrey W. Taub, Hai Lin, Yubin Ge
Journal: Blood (2017)
Mutations in Ribosomal Protein Genes L9 and L15 Link to DBA with Specific Clinical Phenotypes
Authors: Marcin W. Wlodarski, Lydie M. Da Costa, Marie-Francoise O'-Donohue, Marc Gastou, Ina Hainmann, Enikoe Amina Szvetnik, Thierry Leblanc, Marc Bierings, Nathalie Montel-Lehry, Hannah Tamary, Charlotte M. Niemeyer, Pierre-Emmanuel Gleizes, Alyson W. MacInnes
Journal: Blood (2017)
Cost‐effectiveness of the subcutaneous house dust mite allergen immunotherapy plus pharmacotherapy for allergic asthma: A mathematical model
Authors: Devian Parra‐Padilla, Josefina Zakzuk, María Carrasquilla, Nelson Alvis‐Guzmán, Rodolfo Dennis, María X. Rojas, Martín Rondón, Adriana Pérez, Augusto Peñaranda, Ana M. Barragán, Luis Caraballo, Elizabeth García
Journal: Allergy (2020)

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A Randomized Clinical Trial of Anti–IL-6 Antibody Clazakizumab in Late Antibody-Mediated Kidney Transplant Rejection
Authors: Konstantin Doberer, Michael Duerr, Philip F. Halloran, Farsad Eskandary, Klemens Budde, Heinz Regele, Jeff Reeve, Anita Borski, Nicolas Kozakowski, Roman Reindl-Schwaighofer, Johannes Waiser, Nils Lachmann, Sabine Schranz, Christa Firbas, Jakob Mühlbacher, Georg Gelbenegger, Thomas Perkmann, Markus Wahrmann, Alexander Kainz, Robin Ristl, Fabian Halleck, Gregor Bond, Edward Chong, Bernd Jilma, Georg A. Böhmig
Journal: Journal of the American Society of Nephrology (2020)

Late antibody-mediated rejection (ABMR) is a leading cause of transplant failure. Blocking IL-6 has been proposed as a promising therapeutic strategy.
Point-of-Care Ultrasound Findings in Patients with COVID-19 and AKI
Authors: Forrest F. Lindsay-McGinn, Vishnu S. Potluri, Sadichhya Lohani, Claire A. Centeno, Jennifer Morganroth, Christy Moore, Felipe Teran, Nathaniel C. Reisinger
Journal: Journal of the American Society of Nephrology (2020)

Lindsay-McGinn, Forrest F.; Potluri, Vishnu S.; Lohani, Sadichhya; Centeno, Claire A.; Morganroth, Jennifer; Moore, Christy; Teran, Felipe; Reisinger, Nathaniel C. Author Information
In Search of the Elusive Vulnerable Plaque: Reducing the Gap Between Coronary Imaging and Necropsy Findings⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Authors: Robert L. Wilensky
Journal: Journal of the American College of Cardiology (2013)
Central Adiposity and Subsequent Risk of Breast Cancer by Menopause Status
Authors: Serena C Houghton, Heather Eliassen, Rulla M Tamimi, Walter C Willett, Bernard A Rosner, Susan E Hankinson
Journal: JNCI Journal of the National Cancer Institute (2020)

Increased body mass index (BMI) is associated with higher postmenopausal breast cancer risk and lower premenopausal breast cancer risk. Less is known about the central adiposity-breast cancer risk association, particularly for tumor subtypes.We used prospective waist (WC) and hip circumference (HC) measures in the Nurses' Health Studies. We examined associations of WC, HC, and waist-to-hip ratio (WHR) with breast cancer independent of BMI, by menopausal status. Cox proportional hazards models estimated the hazard ratios (HRs) and 95% confidence intervals (CIs) adjusting for breast cancer risk factors, with and without BMI.Adjusting for BMI, WC and HC were not associated, and WHR was positively associated with premenopausal breast cancer risk (WHR, quintile 5 vs 1: HRQ5vQ1, BMI-adjusted = 1.27, 95% CI = 1.04 to 1.54; Ptrend = .01), particularly for estrogen receptor-negative (ER-) and progesterone receptor-negative (PR-) and basal-like breast cancers. Premenopausal WC, HC, and WHR were not associated with postmenopausal breast cancer risk, with or without BMI adjustment. Postmenopausal WC, HC, and WHR were each positively associated with postmenopausal breast cancer (eg, WC HRQ5vsQ1 = 1.59, 95% CI = 1.36 to 1.86); after adjustment for BMI, only WC remained statistically significant (HRQ5vsQ1, BMI-adjusted = 1.38, 95% CI = 1.15 to 1.64; Ptrend = .002). In postmenopausal women, associations were stronger among never-users of hormone therapy and for ER+/PR+ breast cancers.Central adiposity was positively associated with pre- and postmenopausal breast cancers independent of BMI. This suggests that mechanisms other than estrogen may also play a role in the relationship between central adiposity and breast cancer. Maintaining a healthy waist circumference may decrease pre- and postmenopausal breast cancer risk.
Childhood maltreatment and lung function: findings from the general population
Authors: Carsten Spitzer, Ralf Ewert, Henry Völzke, Stefan Frenzel, Stephan B. Felix, Laura Lübke, Hans J. Grabe
Journal: European Respiratory Journal (2020)

Objective Cumulative evidence indicates that childhood maltreatment is linked to self-reported asthma and COPD. However, the relationship between childhood maltreatment and objective measures of lung function as determined by spirometry has not yet been assessed. Methods Medical histories and spirometric lung function were taken in 1386 adults from the general population. Participants completed the Childhood Trauma Questionnaire for the assessment of emotional, physical and sexual abuse as well as emotional and physical neglect. Results 25.3% of the participants reported at least one type of childhood maltreatment. Among them, use of medication for obstructive airway diseases as well as typical signs and symptoms of airflow limitation were significantly more frequent than in the group without exposure to childhood maltreatment. Although participants with childhood maltreatment had numerically lower values for forced expiratory volume in 1 s (FEV 1 ), forced vital capacity (FVC) and peak expiratory flow than those without, these differences were nonsignificant when accounting for relevant covariates such as age, sex, height and smoking. Likewise, there were no differences in the FEV 1 /FVC ratio nor in the frequency of airflow limitation regardless of its definition. No specific type of childhood maltreatment was related to spirometrically determined parameters of lung function. Conclusions Our findings call into question the association of childhood maltreatment with obstructive lung diseases as indicated by prior research relying on self-reported diagnoses. We consider several explanations for these discrepancies.
Abstract 13428: Cardiac Troponin T Level is Associated With Myocardial Recovery in Fulminant Myocarditis
Authors: Toru Kondo, Naoki Shibata, shingo kazama, Yuki Kimura, Hideo Oishi, Tasuku Kuwayama, Hiroaki Hiraiwa, Ryota Morimoto, TAKAHIRO OKUMURA, Toyoaki Murohara
Journal: Circulation (2020)

Background: Fulminant myocarditis (FM) is a fatal disease that causes rapid-onset severe heart failure requiring inotropes or mechanical circulatory support (MCS). Because insufficient myocardial recovery requires durable left ventricular assist device or heart transplantation, the course of myocardial recovery should be predicted. Hypothesis: Cardiac troponins, which elevates due to myocardial damage, may associate with myocardial recovery in FM. Purpose: We aimed to investigate the relationship between cardiac troponin T (TnT) levels and myocardial recovery course in patients with FM. Method: We performed a retrospective medical record review of 19 patients with FM requiring MCS from May 2012 to January 2020. The serial changes of one-week left ventricular ejection fraction (LVEF) after MCS implantation according to TnT levels were evaluated. Results: Median age was 50 years and 10 patients were male. As for initial MCS, veno-arterial extracorporeal membrane oxygenation (VA-ECMO) with intra-aortic balloon pumping (IABP) were used in 13 patients, IABP in 4 patients, VA-ECMO in one patient, and impella 2.5 in one patient. Median peak TnT level within one week after MCS implantation were 4.43 (2.47 - 34.6) ng/mL. The patients were divided into High-TnT group and Low-TnT group according to median peak TnT level. All patients in both groups were alive until 7 days after MCS implantation, and LVEF on day 7 was significantly lower in the High-TnT group (Fig). TnT level was highest on day 1 and gradually decreased in the High-TnT group (Fig). Six patients died during hospitalization in the High-TnT group, in contrast, only one patient died in the Low-TnT group (p=0.020). Peak TnT level in patients with LVEF ≥30% (n=8) on day 7 was significantly lower than in patients with LVEF &lt;30% (2.40 vs 13.5 ng/mL, p=0.012), however, other laboratory parameters showed no significant differences. Conclusion: Higher TnT level showed impaired myocardial recovery in patients with FM.
Longitudinal changes to quadriceps thickness demonstrate acute sarcopenia following admission to hospital for an exacerbation of chronic respiratory disease
Authors: Hamish J C McAuley, Theresa C Harvey-Dunstan, Michelle Craner, Matthew Richardson, Sally J Singh, Michael C Steiner, Neil J Greening
Journal: Thorax (2020)

Acute admission to hospital for an exacerbation of chronic respiratory disease (CRD) may impair skeletal muscle mass and function. We measured quadriceps thickness (Q thick ), as a surrogate marker of muscle mass, at hospital admission, discharge, 6 weeks and 3 months in 55 patients with CRD. Q thick fell by 8.3% during the period of hospitalisation, which was sustained at 6 weeks, and only partially recovered at 3 months. Sustained loss was most marked in patients readmitted during the follow-up period. Acute reduction in quadriceps muscle mass occurs during hospitalisation, with prolonged and variable recovery, which is prevented with subsequent hospital readmission.
Disease course of neurofibromatosis type 2: a 30-year follow-up study of 353 patients seen at a single institution
Authors: Claire Forde, Andrew T King, Scott A Rutherford, Charlotte Hammerbeck-Ward, Simon K Lloyd, Simon R Freeman, Omar N Pathmanaban, Emma Stapleton, Owen M Thomas, Roger D Laitt, Stavros Stivaros, John-Paul Kilday, Grace Vassallo, Catherine McBain, Simon Kerrigan, Miriam J Smith, Martin G McCabe, Elaine F Harkness, D Gareth Evans
Journal: Neuro-Oncology (2020)

Abstract Background Limited data exist on the disease course of neurofibromatosis type 2 (NF2) to guide clinical trial design. Methods A prospective database of patients meeting NF2 diagnostic criteria, reviewed between 1990 and 2020, was evaluated. Follow-up to first vestibular schwannoma (VS) intervention and death was assessed by univariate analysis and stratified by age at onset, era referred, and inheritance type. Interventions for NF2-related tumors were assessed. Cox regression was performed to determine the relationship between individual factors from time of diagnosis to NF2-related death. Results Three hundred and fifty-three patients were evaluated. During 4643.1 follow-up years from diagnosis to censoring, 60 patients (17.0%) died. The annual mean number of patients undergoing VS surgery or radiotherapy declined, from 4.66 and 1.65, respectively, per 100 NF2 patients in 1990-1999 to 2.11 and 1.01 in 2010-2020, as the number receiving bevacizumab increased (2.51 per 100 NF2 patients in 2010-2020). Five patients stopped bevacizumab to remove growing meningioma or spinal schwannoma. 153/353 (43.3%) had at least one neurosurgical intervention/radiation treatment within 5 years of diagnosis. Patients asymptomatic at diagnosis had longer time to intervention and better survival compared to those presenting with symptoms. Those symptomatically presenting &amp;lt;16 and &amp;gt;40 years had poorer overall survival than those presenting at 26-39 years (P = .03 and P = .02, respectively) but those presenting between 16 and 39 had shorter time to VS intervention. Individuals with de novo constitutional variants had worse survival than those with de novo mosaic or inherited disease (P = .004). Conclusion Understanding disease course improves prognostication, allowing for better-informed decisions about care.
Correspondence on ‘Critical role of neutrophil extracellular traps (NETs) in patients with Behcet’s disease’
Authors: Jiali Chen, Tian Liu, Jing He, Yudong Liu
Journal: Annals of the Rheumatic Diseases (2020)

Correspondence on 'Critical role of neutrophil extracellular traps (NETs) in patients with Behcet's disease' CorrespondenceFigure 1 Low-density granulocytes (LDGs) are elevated in Behcet's disease (BD) and are associated with vascular involvement.(A) Frequency of LDGs in patients with active BD, inactive BD and healthy controls (HCs).(B) Neutrophil-to-lymphocyte ratio (NLR) in patients with active BD, inactive BD and HCS.(C) LDG-to-lymphocyte ratio (LLR) in patients with active BD, inactive BD and HCs.(D) Frequency of LDGs in BD patients with vascular involvement, in BD patients without vascular involvement and HCs.(E) LLR in BD patients with vascular involvement, in BD patients without vascular involvement and HCs.PBMC, peripheral blood mononuclear cell.on August 16,
ASGCT 22nd Annual Meeting Abstracts
Authors: Veronique Bolduc,, Reghan Foley, A., Herimela Solomon-Degefa,, Apurva Sarathy,, Sandra Donkervoort,, Ying Hu,, S. Chen, Grace, Matthew Nalls,, Haiyan Zhou,, Sara Aguti,, B. Cummings, Beryl, Monkol Lek,, Taru Tukiainen,, L. Marshall, Jamie, Oded Regev,, Dina Marek-Yagel,, Anna Sarkozy,, J. Butterfield, Russell, Cristina Jou,, Cecilia Jimenez-Mallebrera,, Yan Li,, Jun Cheng,, Lisa Garrett,, Corine Gartioux,, Kamel Mamchaoui,, Valerie Allamand,, Francesca Gualandi,, Alessandra Ferlini,, Eric Hanssen,, D. Wilton, Steve, R. Lamande, Shireen, G. Macarthur, Daniel, Raimund Wagener,, Francesco Muntoni,, G. Bonnemann, Carsten
Journal: Molecular Therapy (2019)

Immunogenicity of a New Flaviviral-Based DNA Launched Suicidal Replicon for Protective Vaccination Against Hepatitis C
KPMW135, a Biosuperior CD3 Bispecific Version of Rituximab Created By a Novel Chemical Conjugation Technology Demonstrates Increased Anti-Tumor Activity By Adding T Cell-Mediated Cytotoxicity Activity to the Existing Mechanisms of Rituximab
Authors: Christian Vidal, Michael Cukan, Ada Vaill, Anna Bunin, Ann Marie Rossi, Lawrence Iben, David Trinh, Katy McGrath, Tanya Berbasova, Rizwan Romee, Enrique Alvarez, Luca Rastelli, Matthew Welsch
Journal: Blood (2020)
Anger, Depression, and Anxiety in Cardiac Patients: The Complexity of Individual Differences in Psychological Risk**Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Authors: Johan Denollet, Susanne S. Pedersen
Journal: Journal of the American College of Cardiology (2009)
Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis
Authors: Stefan A. Berghoff, Lena Spieth, Ting Sun, Leon Hosang, Lennart Schlaphoff, Constanze Depp, Tim Düking, Jan Winchenbach, Jonathan Neuber, David Ewers, Patricia Scholz, Franziska van der Meer, Ludovico Cantuti-Castelvetri, Andrew O. Sasmita, Martin Meschkat, Torben Ruhwedel, Wiebke Möbius, Roman Sankowski, Marco Prinz, Inge Huitinga, Michael W. Sereda, Francesca Odoardi, Till Ischebeck, Mikael Simons, Christine Stadelmann-Nessler, Julia M. Edgar, Klaus-Armin Nave, Gesine Saher
Journal: Nature Neuroscience (2020)
Safety of CAR T-cell therapy in kidney transplant recipients
Authors: Omar Mamlouk, Ranjit Nair, Swaminathan P. Iyer, Angelina Edwards, Sattva S. Neelapu, Raphael E. Steiner, Sherry A. Adkins, Misha Hawkins, Neeraj Saini, Kartik Devashish, Paolo Strati, Sreedhar Mandayam, Sairah Ahmed
Journal: Blood (2020)
Differences in Long-term Outcomes After Coronary Artery Bypass Grafting Using Single vs Multiple Arterial Grafts and the Association With Sex
Authors: Mario Gaudino, Zaza Samadashvili, Irbaz Hameed, Joanna Chikwe, Leonard N. Girardi, Edward L. Hannan
Journal: JAMA Cardiology (2020)

<h3>Importance</h3> Sex-related differences in the outcome of using multiple arterial grafts during coronary artery bypass grafting (CABG) remain uncertain. <h3>Objective</h3> To compare the outcomes of the use of multiple arterial grafts vs a single arterial graft during CABG for women and men. <h3>Design, Setting, and Participants</h3> This statewide cohort study used data from New York's Cardiac Surgery Reporting System and New York's Vital Statistics file on 63 402 patients undergoing CABG from January 1, 2005, to December 31, 2014. Statistical analysis was performed from January 10 to August 20, 2020. <h3>Exposures</h3> Multiple arterial grafting or single arterial grafting. <h3>Main Outcomes and Measures</h3> Mortality, acute myocardial infarction (AMI), stroke, repeated revascularization, major adverse cardiac and cerebrovascular event (composite of mortality, AMI, and stroke), and major adverse cardiac event (composite of mortality, AMI, or repeated revascularization) were compared among propensity-matched patients and stratified by the risk of long-term mortality. <h3>Results</h3> Of the 63 402 patients (48 155 men [76.0%]; mean [SD] age, 69.9 [10.5] years) in the study, women had worse baseline characteristics than men for most of the explored variables. Propensity matching yielded a total of 9512 male pairs and 1860 female pairs. At 7 years of follow-up, mortality was lower among men who underwent multiple arterial grafting (adjusted hazard ratio, 0.80; 95% CI, 0.73-0.87) but not women who underwent multiple arterial grafting (adjusted hazard ratio, 0.99; 95% CI, 0.84-1.15). When stratified by the estimated risk of death, the use of multiple arterial grafts was associated with better survival and a lower rate of a major adverse cardiac event among low-risk, but not high-risk, patients of both sexes, and the risk cutoff was different for men and women. <h3>Conclusions and Relevance</h3> This study suggests that women have a worse preoperative risk profile than men. Multiple arterial grafting is associated with better outcomes among low-risk, but not high-risk, patients, and the risk cutoffs differ between sexes. These data highlight the need for new studies on the outcome of multiple arterial grafts in women.