tbuckley/cabot-search huggingface dataset:
Health-Related Quality of Life in the Cartitude-1 Study of Ciltacabtagene Autoleucel for Relapsed/Refractory Multiple Myeloma
Authors: Thomas Martin, Yi Lin, Mounzer Agha, Adam D. Cohen, Myo Htut, A. Keith Stewart, Parameswaran Hari, Jesus G. Berdeja, Deepu Madduri, Saad Z. Usmani, Tzu-Min Yeh, Alicia J. Allred, Yunsi Olyslager, Arnob Banerjee, Jenna D. Goldberg, Jordan M. Schecter, Carolyn C. Jackson, William Deraedt, Katharine S. Gries, John Fastenau, Xiaoling Wu, Marlene J. Carrasco, Muhammad Akram, Farah Hossain, Andrzej Jakubowiak, Sundar Jagannath
Journal: Blood (2020)
Association of Circulating Monocyte Chemoattractant Protein–1 Levels With Cardiovascular Mortality
Authors: Marios K. Georgakis, James A. de Lemos, Colby Ayers, Biqi Wang, Harry Björkbacka, Tiberiu A. Pana, Barbara Thorand, Caroline Sun, Lana Fani, Rainer Malik, Josée Dupuis, Gunnar Engström, Marju Orho-Melander, Olle Melander, S. Matthijs Boekholdt, Astrid Zierer, Mohamed A. Elhadad, Wolfgang Koenig, Christian Herder, Ron C. Hoogeveen, Maryam Kavousi, Christie M. Ballantyne, Annette Peters, Phyo K. Myint, Jan Nilsson, Emelia J. Benjamin, Martin Dichgans
Journal: JAMA Cardiology (2020)

Human genetics and studies in experimental models support a key role of monocyte-chemoattractant protein-1 (MCP-1) in atherosclerosis. Yet, the associations of circulating MCP-1 levels with risk of coronary heart disease and cardiovascular death in the general population remain largely unexplored.
Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice
Authors: Vaishnavi S. Jadhav, Peter B. C. Lin, Taylor Pennington, Gonzalo Viana Di Prisco, Asha Jacob Jannu, Guixiang Xu, Miguel Moutinho, Jie Zhang, Brady K. Atwood, Shweta S. Puntambekar, Stephanie J. Bissel, Adrian L. Oblak, Gary E. Landreth, Bruce T. Lamb
Journal: Molecular Neurodegeneration (2020)

Abstract Background Triggering receptor expressed on myeloid cells 2 (TREM2) is expressed in the brain exclusively on microglia and genetic variants are linked to neurodegenerative diseases including Alzheimer’s disease (AD), frontotemporal dementia (FTD) and Nasu Hakola Disease (NHD). The Trem2 variant R47H, confers substantially elevated risk of developing late onset Alzheimer’s disease, while NHD-linked Trem2 variants like Y38C, are associated with development of early onset dementia with white matter pathology. However, it is not known how these Trem2 species, predisposes individuals to presenile dementia. Methods To investigate if Trem2 Y38C or loss of Trem2 alters neuronal function we generated a novel mouse model to introduce the NHD Trem2 Y38C variant in murine Trem2 using CRISPR/Cas9 technology. Trem2 Y38C/Y38C and Trem2 −/− mice were assessed for Trem2 expression, differentially expressed genes, synaptic protein levels and synaptic plasticity using biochemical, electrophysiological and transcriptomic approaches. Results While mice harboring the Trem2 Y38C exhibited normal expression levels of TREM2, the pathological outcomes phenocopied Trem2 −/− mice at 6 months. Transcriptomic analysis revealed altered expression of neuronal and oligodendrocytes/myelin genes. We observed regional decreases in synaptic protein levels, with the most affected synapses in the hippocampus. These alterations were associated with reduced synaptic plasticity. Conclusion Our findings provide in vivo evidence that Trem2 Y38C disrupts normal TREM2 functions. Trem2 Y38C/Y38C and Trem2 −/− mice demonstrated altered gene expression, changes in microglia morphology, loss of synaptic proteins and reduced hippocampal synaptic plasticity at 6 months in absence of any pathological triggers like amyloid. This suggests TREM2 impacts neuronal functions providing molecular insights on the predisposition of individuals with TREM2 variants resulting in presenile dementia.
Ixazomib-Rituximab in Untreated Indolent B-NHL: An Effective, Very Low Toxicity Regimen
Authors: Solomon A. Graf, Ryan C. Lynch, Ted A Gooley, Chaitra S. Ujjani, Peter Wilcox, Sabrina Wilcox, David G. Coffey, Andrew J. Cowan, Stephen D. Smith, Mazyar Shadman, Edus H. Warren, Edward Libby, Colin D. Godwin, Ryan D. Cassaday, Jonathan R. Fromm, Ajay K. Gopal
Journal: Blood (2020)
Abstract 330: Expression of Glycolytic Enzymes in Induced Pluripotent Stem Cells, Derived Megakaryocytes, and Endothelial Cells
Authors: Arun Chandra, Dhananjay Vaidya, Rui Chang, Josh Knowles, Ivan Carcamo-oribe, Kai Kammers, Joshua Martin, Margaret Taub, Dixie Hoyle, Yongxing Gao, Lisa Yanek, Brian Kral, Nauder Faraday, Diane Becker, Rasika Mathias, Linzhao Cheng, Jeffrey Leek, Zack Wang, Lewis Becker
Journal: Circulation Research (2020)

Introduction: Induced pluripotent stem cells (iPSC) have a significant capacity for self-renewal and can differentiate into any somatic cell type, such as megakaryocytes (MK) and vascular endothelial cells (EC). We have previously shown that iPSC-derived MKs (IPSC-MK) upregulate the gene expression levels of irreversible glycolytic enzymes committing glucose to glycolysis in comparison to their parental iPSC lines (Vaidya et al., 2016). This pattern differed from past comparisons between somatic source cells and iPSCs (Chung et al., 2007; Varum et al., 2011; Zhang et al., 2011). To further corroborate our data, we extended our analysis to iPSC-derived ECs (iPSC-EC). Methods: We studied expression of glycolytic enzyme genes in 30 human iPSC lines and paired iPSC-EC and iPSC-MK lines using RNA-seq. iPSC-EC to iPSC expression ratios for 11 glycolytic enzymes were estimated using a multilevel mixed-effect model regression, and a significance threshold of p &lt; 0.05/11 = 0.0045 was used. A bivariate statistical analysis was used to assess the correlation between iPSC-EC and iPSC-MK data. Results: Of the 11 glycolytic enzymes studied, 4 were highly expressed in iPSC-ECs (Log2(iPSC-EC/iPSC) ≥ 1) while 1 was highly expressed in iPSCs (Log2(iPSC/iPSC-EC) ≥ 1). Transcripts for functionally irreversible enzymes including ADPGK, PFKP, and PKLR displayed higher expression levels in iPSC-ECs compared to iPSCs. Similarly, 6 glycolytic genes demonstrated higher expression in iPSC-MKs, while 2 were more highly expressed in iPSCs. The functionally irreversible enzymes HK1, ADPGK, and PFK exhibited higher expression levels in iPSC-MKs. The ratios of gene expression (derived-lines:iPSCs) for all 37 genes in the iPSC-MK results correlated with those of the iPSC-EC results: Pearson’s r = 0.52, p = 0.001. Conclusion: Both iPSC-ECs and iPSC-MKs upregulate the expression of glycolytic enzymes compared to their parental iPSCs. In light of data showing that differentiated cells are more metabolically active and have more mitochondria than iPSCs (Chandra et al., 2020), these results suggest that differentiation of iPSCs is accompanied by an increase in both glycolytic and TCA cycle activities, with glycolytic generation of pyruvate used for mitochondrial production of ATP.
Caution in interpretation of abnormal carbon monoxide diffusion capacity in COVID-19 patients
Authors: David G. Chapman, Tanya Badal, Gregory G. King, Cindy Thamrin
Journal: European Respiratory Journal (2020)

<b>Reduced <i>K</i><sub>CO</sub> in discharged patients with COVID-19 suggests persistent abnormalities in gas exchange. Further research is required to understand why.</b>https://bit.ly/2Hb00gq
Outcome of Severe Vaso-Occlusive Crisis in Sickle Cell Disease Adults Admitted to Referral Centers in Africa and Europe. Introduction of Machine Learning Methods to Improve the Presev Score
Authors: Yamna Ouchtar, Christian Kassasseya, Kene Sekou, Anne-Laure Pham Hung D'Alexandry D'Orengiani, Mehdi Kellaf, Dapa Aly Diallo, Laurent Najman, Pablo Bartolucci
Journal: Blood (2020)
Increased Detection of <i>KIT</i> D816V Mutation in Peripheral Blood Samples from Patients with Indolent Systemic Mastocytosis (ISM) in the Phase 2 Pioneer Study Using a High Sensitivity Droplet Digital (dd) PCR Assay Compared with Next Generation Sequencing (NGS)
Authors: Tracy I. George, Gerard Hoehn, Hui-Min Lin, Stephen Miller, Cem Akin
Journal: Blood (2020)
Low Utility of the H-Score and HLH-2004 Criteria to Identify Patients with Secondary Hemophagocytic Lymphohistiocytosis after CAR-T Cell Therapy for Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Authors: Dong Won Kim, Forat Lutfi, Facundo Zafforoni, Moaath Mustafa Ali, Ali Bukhari, David Gottlieb, Seung-Tae Lee, Mehmet Hakan Kocoglu, Nancy M. Hardy, Jean A. Yared, Aaron P. Rapoport, Jennie Y. Law, Saurabh Dahiya
Journal: Blood (2020)
Next-Generation Sequencing Minimal Residual Disease of Mantle Cell Lymphoma in Autologous Stem Cell Grafts and Its Implication on Tumor Recurrence
Authors: Yu-Hung Wang, Yi-Kuang Chuang, Yu-Hsuan Yang, Shan-Chi Yu, Yi-Tsung Yang, Bor-Sheng Ko, Ming Yao, Tai-Chung Huang, Jih-Luh Tang
Journal: Blood (2020)
Targeting Mcl-1 Enhances the Activity of Tyrosine Kinase Inhibitor Gilteritinib in FLT3 Mutated AML
Authors: Bing Z Carter, Po Yee Mak, Vivian Ruvolo, Wenjing Tao, Paul Hughes, Xiaoyue Chen, PK Morrow, Michael Andreeff
Journal: Blood (2020)
Next-Generation Sequencing (NGS)-Based Measurable Residual Disease (MRD) Monitoring in Acute Myeloid Leukemia with <i>FLT3</i> Internal Tandem Duplication (<i>FLT3</i>-ITD+ AML) Treated with Additional Midostaurin
Authors: Julia K. Herzig, Frank G. Rücker, Laura K. Schmalbrock, Tamara J. Blätte, Daniela Weber, Sabrina Skambraks, Silke Kapp-Schwoerer, Andrea Corbacioglu, Verena I Gaidzik, Peter Paschka, Ekaterina Panina, Nikolaus Jahn, Anika Schrade, Frauke Theis, Sibylle Cocciardi, Walter Fiedler, Helmut R. Salih, Gerald Wulf, Hans Salwender, Thomas Schroeder, Katharina S. Götze, Thomas Kindler, Michael Luebbert, Richard F. Schlenk, Felicitas Thol, Michael Heuser, Arnold Ganser, Hartmut Döhner, Lars Bullinger, Konstanze Döhner
Journal: Blood (2020)
Hypertension, Cardiovascular and Renal Complications Observed in Patients with Chronic Lymphocytic Leukemia Receiving Long-Term Therapy with Ibrutinib
Authors: Jade Jones, Binsah Susan George, Christine B Peterson, Thao-Mi Tran Ha, Jan A. Burger, Nitin Jain, Michael J. Keating, William G. Wierda, Jean-Bernard Durand, Alessandra Ferrajoli
Journal: Blood (2020)
The Integrin Adaptor Kindlin-3 Is Important for Development and Retention of Marginal Zone B Cells
Authors: Andrea Härzschel, Peter William Krenn, Elisabeth Bayer, Simone Tangermann, Geoffroy Andrieux, Elif Karabatak, Eva Szenes, Danielle-Justine Danner, Ursula Denk, Raphael Ruppert, Alexander Egle, Richard Greil, Lukas Kenner, Melanie Boerries, Tanja Nicole Hartmann
Journal: Blood (2020)
Efficacy of Four Drug Regimens in Multiple Myeloma: A Systemic Review
Authors: Sundas Ali, Insija Ilyas Selene, Muhammad Tayyeb, Zahoor Ahmed, Farhan Khalid, Muhammad Talha Liaquat, Ali Jaan, Muhammad Salman Faisal, Abdul Jabbar Dar, Qasim Khurshid, Muhammad Ali Mirza, Faiz Anwer
Journal: Blood (2020)
Efficacy of Idelalisib and Rituximab in Relapsed/Refractory Chronic Lymphocytic Leukemia Treated Outside of Clinical Trial. a Report of the Gimema Group
Authors: Gian Matteo Rigolin, Annamaria Frustaci, Alfonso Piciocchi, Andrea Visentin, Orsola Vitagliano, Marta Coscia, Lucia Farina, Gianluca Gaidano, Roberta Murru, Marzia Varettoni, Luca Arcaini, Francesca Cibien, Rossella Paolini, Paolo Sportoletti, Daniela Pietrasanta, Anna Lia Molinari, Francesca M. Quaglia, Luca Laurenti, Roberto Marasca, Monia Marchetti, Annalisa Chiarenza, Francesca Romana Mauro, Omar Perbellini, Donato Mannina, Rosaria Sancetta, Attilio Olivieri, Stefano Molica, Fabrizio Pane, Caterina Patti, Fiorella Iliariucci, Alessandro Gozzetti, Catello Califano, Piero Galieni, Accursio Fabio Augello, Daniele Vallisa, Francesca Cura, Enrico Crea, Paola Fazi, Giulia Zamprogna, Mauro Krampera, Livio Trentin, Felicetto Ferrara, Massimo Gentile, Marco Montillo, Robin Foà, Antonio Cuneo
Journal: Blood (2020)
Cost-Effectiveness of Once-Weekly Selinexor, Bortezomib, and Dexamethasone (SVd) Versus Twice-Weekly Bortezomib and Dexamethasone (Vd) in Relapsed or Refractory Multiple Myeloma
Authors: Kishan Patel, Terri L. Parker, Mengyang Di, Noffar Bar, Scott F. Huntington, Smith Giri
Journal: Blood (2020)
A Pilot Study of Brentuximab Vedotin, Rituximab and Dose Attenuated CHP in Patients 75 Years and Older with Diffuse Large B-Cell Lymphoma
Authors: Patrick M. Reagan, Craig A. Portell, Carla Casulo, Andrea M. Baran, Allison Magnuson, Paul M. Barr, Yelena Lerman, Krista N French, Jonathan W. Friedberg
Journal: Blood (2020)
"Low Dose Ganciclovir for Cytomegalovirus Reactivation after Allogeneic HSCT Is a Feasible Option with Same Efficacy and Less Toxicity Than Regular Dose"
Authors: Roberta Azevedo, Vinicius Campos Molla, Jessica Fernandes Ramos, Danilo Belchior Ponciano, Pedro Henrique Arruda De Moraes, Ana Rita Da Fonseca, Maria Cristina Nunez Seiwald, Mariana Serpa, Aliana Meneses Ferreira, Roberta Shcolnik Szor, Rayana Bomfim Leonel, Erick Menezes Xavier, Luciana Tucunduva, Vanderson Rocha, Yana Novis, Esper Kallas, Marcio Nucci, Celso Arrais-Rodrigues
Journal: Blood (2020)
Early Versus Late Autologous Stem Cell Transplant in Newly Diagnosed Multiple Myeloma: Long-Term Follow-up Analysis of the IFM 2009 Trial
Authors: Aurore Perrot, Valerie Lauwers-Cances, Titouan Cazaubiel, Thierry Facon, Denis Caillot, Lauriane Clement-Filliatre, Margaret Macro, Olivier Decaux, Karim Belhadj, Mohamad Mohty, Lionel Karlin, Jean Claude Eisenmann, Mourad Tiab, Frederique Orsini, Cyrille Touzeau, Xavier Leleu, Herve Avet-Loiseau, Nikhil C. Munshi, Kenneth Anderson, Paul G. Richardson, Philippe Moreau, Michel Attal
Journal: Blood (2020)
Setbp1 Overexpression Acts in the Place of Class-Defining Somatic Mutations to Drive Mouse and Human FLT3-ITD-Mutant AMLs
Authors: Suruchi Pacharne, Oliver M. Dovey, Jonathan L Cooper, Muxin Gu, Vijay Baskar, Mathias J Friedrich, Malgorzata Gozdecka, Sandeep S Rajan, Etienne De Braekeleer, Maxim Barenboim, Grace Collord, Hannes Postingl, Ruben Bautista, Milena Mazan, Roland Rad, Konstantinos Tzelepis, Penny Wright, George S. Vassiliou
Journal: Blood (2020)
Abstract 15985: Real-World Use of Implantable Loop Recorder Following Cryptogenic Stroke: Who Actually Benefits From Long Term Monitoring and How Long Should They Remain Implanted?
Authors: Emily Howe, Daniel Pugliese, Margaret Zhou, Joshua Z Willey, Hasan Garan, Jose M Dizon, Elaine Y Wan
Journal: Circulation (2019)

Introduction: Insertion of implantable loop recorder (ILR) after cryptogenic stroke for detection of AF has increased since CRYSTAL-AF. However, it is unclear which patients actually benefit from l...
A Phase 1/2 Study to Evaluate the Safety and Efficacy of Ponatinib with Chemotherapy in Pediatric Patients with Philadelphia Chromosome-Positive (Ph+) Acute Lymphoblastic Leukemia (ALL)
Authors: Yousif Matloub, Lia Gore, Mignon L. Loh, Chin-Hon Pui, Michael J. Hanley, Vickie Lu, E. Jane Leonard, Muriel Granier, Andrea Biondi, Lewis B. Silverman
Journal: Blood (2020)
Comparative Transcriptomics of Alpha-Beta Subcutaneous Panniculitis-like T-Cell Lymphoma and Primary Cutaneous Gamma Delta T-Cell Lymphoma
Authors: Xing Li, Kevin J Severson, Meera H Patel, Caitlin M Brumfiel, Alysia Hughes, David DiCaudo, Nneka Comfere, Jason Sluzevich, Allison C. Rosenthal, Carlos A Torres-Cabala, Mark R Pittelkow, Aaron R Mangold
Journal: Blood (2020)
A Randomized Study of Bortezomib, Cyclophosphamide and Dexamethasone Induction (VCD) Versus VCD and Daratumumab Induction Followed By Daratumumab Maintenance (VCDD) for the Initial Treatment of Transplant-Ineligible Patients with Multiple Myeloma (AMaRC 03-16)
Authors: Peter Mollee, John Reynolds, Wojt Janowski, Hang Quach, Philip Campbell, Simon D. Gibbs, Sophie Lee, James D'Rozario, Kerry Taylor, Tara Cochrane, Craig Thomas Wallington-Beddoe, Fiona Kwok, Nicholas Weber, Ian H. Kerridge, Helen Weston, Phoebe Joy Ho, Noemi Horvath, Flora Yuen, Andrew Spencer
Journal: Blood (2020)
Treatment with CPX-351 Induces Deep Responses and TP53 Mutation Clearance in Patients with t-AML and AML MRC, Including Younger Patients and Those with Pre-Existing MPNs: A Real-World Experience
Authors: Gee Youn (Geeny) Kim, Jamie L. Koprivnikar, Rebecca Testi, Tara McCabe, Grace Perry, Danielle Marcotulli, Elizabeth Jones, Xue Geng, Ming Tan, James K. McCloskey
Journal: Blood (2020)
An Australasian Bone Marrow Transplant Registry (ABMTR) Study of the Trends and Outcomes of Allogeneic Haematopoietic Stem Cell Transplantation (HSCT) in Hodgkin Lymphoma between 2009-2019: Relapse Remains the Most Common Cause of Death Post Transplantation
Authors: Kirsty M Sharplin, David Ritchie, David Gottlieb, Ian Bilmon, Shyam Panicker, Glen A Kennedy, Cameron Curley, Duncan Purtill, Julian Cooney, Richard Doocey, Leanne Berkahn, Sam Milliken, Pietro R Di Ciaccio, Peter G Bardy, Andrew Spencer, David J. Curtis, Sushrut S. Patil, Stephen R Larsen, Travis Perera, Andrew Butler, Matthew Greenwood, Anne-Marie Watson, Hock Choong Lai, Eric Wong, Steven Tran, Nada Hamad
Journal: Blood (2020)
Ibrutinib before Apheresis May Improve Tisagenlecleucel Manufacturing in Relapsed/Refractory Adult Diffuse Large B-Cell Lymphoma: Initial Results from a Phase 1b Study
Authors: Julio C. Chavez, Frederick L. Locke, Ellen Napier, Carl Simon, Andrew Lewandowski, Rakesh Awasthi, Boris Engels, Petrina Georgala, Attilio Bondanza, Stephen J. Schuster
Journal: Blood (2020)
Association between air pollution and atopic dermatitis in Guangzhou, China: modification by age and season*
Authors: H.L. Wang, J. Sun, Z.M. Qian, Y.Q. Gong, J.B. Zhong, R.D. Yang, C.L. Wan, S.Q. Zhang, D.F. Ning, H. Xian, J.J. Chang, C.J. Wang, E. Shacham, J.Q. Wang, H.L. Lin
Journal: British Journal of Dermatology (2020)

Background The short-term effect of ambient air pollution on atopic dermatitis (AD), along with its effect modifiers, has not been fully addressed. Objectives To examine the short-term associations between air pollution and AD, and to identify effect modifications by age and season. Methods We used the generalized additive model to evaluate the short-term effect of ambient air pollution on daily hospital visits for AD, adjusting for potential confounders. Subgroup analyses were performed to identify potential effect modifications by season and age (< 18 years and ≥ 18 years). Results A total of 29 972 hospital visits for AD were recorded in Guangzhou, China, from 19 January 2013 to 31 December 2017. Among them, 72·8% were visits by children and 51·4% occurred in the cool season. Acute and delayed effects on AD hospital visits were significant for all air pollutants. Stronger effects were seen in the cool season (approximately 1·7–3·0 times higher than effects in the warm season). Stronger effects were also observed in children (approximately 1·3–1·8 times higher than effects in adults). Sensitivity analyses indicated the results were robust. Conclusions Air pollution might be an important trigger for AD in subtropical Guangzhou, China. Children are more vulnerable than adults, and the effects are stronger in the cool season.
Safety and Efficacy of Pembrolizumab Prior to Allogeneic Stem Cell Transplant in Patients with Acute Myeloid Leukemia
Authors: Nicholas P. Tschernia, Vaibhav Kumar, Dominic T. Moore, Benjamin G. Vincent, Callie C. Coombs, Hendrik Van Deventer, Matthew C. Foster, Amy E. DeZern, Leo Luznik, Marcie L. Riches, Jonathan S. Serody, Ivana Gojo, Joshua F. Zeidner
Journal: Blood (2020)
Increased Tumor Specific Cytotoxic T Cell Responses and Reversion to a Favorable Cytokine Profile after Treatment in Patients with Newly Diagnosed High Risk Hodgkin Lymphoma Treated on Children's Oncology Group Trial-AHOD1331
Authors: Hema Dave, Mimi Mai, Anushree Datar, Gaye Jenkins, Qinglin Pei, Yue Wu, Frank G. Keller, Sharon M. Castellino, Terzah M Horton, Catherine M. Bollard
Journal: Blood (2020)
Sixty seconds on . . . need for recovery
Authors: Zosia Kmietowicz
Journal: BMJ (2020)

You’re not the only medic in search of a breather. A 2019 survey of 4000 British and Irish emergency department doctors found that their median need for recovery (NFR) score was 70—against an average score of between 36 and 44 reported in the literature. The trainee led evaluation of inter-shift recovery in the emergency department (TIRED study), published in BMJ Open on 2 November, is the first …
Late Breaking Abstract - Lung ultrasound for severity assessment and outcome prediction of COVID-IQ patients
Authors: P. T. Sabria, M. Molina-Molina, S. Aso-González, M. Díez-Ferrer, J. Sabater-Riera, J. Dorca-Sargatal, S. Santos-Pérez, G. Suárez-Cuartin
Journal: European Respiratory Journal (2020)

Introduction: Coronavirus disease 2019 (COVID-19) patients can develop severe bilateral pneumonia leading to acute respiratory failure  Lung ultrasound (LU) might be a useful tool for the evaluation of these patients  LU Score (LUS) is a twelve-zone examination method for the assessment of lung parenchyma  Aim: To evaluate LUS as a tool for severity assessment and outcome prediction of COVID-19 patients  Methods: Observational and prospective pilot study, including patients admitted to the Intermediate Respiratory Care Unit (IMCU) of Bellvitge University Hospital (Barcelona, Spain)  LUS scored from 0-36 points using a convex transducer  Patient data was collected at inclusion  A composite outcome of death or Intensive Care Unit (ICU) admission was used  Patients were followed-up until composite outcome was observed or hospital discharge  Patients were stratified in two groups using LUS>24 as the cut-off point  Results: Thirty-six patients were included  Of them, 69 4% were male  Mean age was 60 2±12 8 years  Median LUS was 23 5 points  A cut-off point for LUS>24 showed 100% sensitivity, 69 2% specificity and AUROC 0 846 for identifying patients with worse prognosis  The composite outcome was observed in 10 (55 6%) patients of the LUS>24 group but not in the LUS24 points  Significant correlations were observed between LUS and Sp02/Fi02 ratio, serum D-Dimer, C-Reactive protein, lactate dehydrogenase and lymphocyte count  Conclusion: LU is a useful tool for the assessment of COVID-19 severity in patients admitted to an IMCU  A LUS>24 points is related to worse prognosis defined as ICU admission requirement or death
Elucidating Mechanisms of Acquired Resistance to IDH Inhibition By Saturation Variant Screening of Base-Edited Leukemia Cells
Authors: Junhua Lyu, Yuxuan Liu, Hui Cao, Mingyi Chen, Yazan F. Madanat, Yuannyu Zhang, Zhimin Gu, Pranita Kaphle, Kathryn E. Dickerson, Paul Yenerall, Rahul Kollipara, Ralf Kittler, John Minna, Weina Chen, Stephen Chung, Robert H. Collins, Xin Liu, Jian Xu
Journal: Blood (2020)