tbuckley/cabot-search huggingface dataset:
Relation between vasa recta blood flow and renal interstitial hydrostatic pressure during pressure natriuresis.
Authors: EFarrugia, J CLockhart, T SLarson
Journal: Circulation Research (1992)

Pressure natriuresis may be mediated through increases in inner medullary vasa recta blood flow (QVR). By means of acute renal decapsulation to prevent increases in renal interstitial hydrostatic pressure (RIHP), the effect of increases in QVR in the presence and absence of changes in RIHP in the natriuretic and diuretic responses to increases in renal perfusion pressure (RPP) was evaluated. Blood flow in descending (QDVR) and ascending (QAVR) vasa recta was determined in the exposed papilla by fluorescence videomicroscopy in anesthetized euvolemic Munich Wistar rats. In rats with intact renal capsules (n = 12), increases in RPP from 101 +/- 0.5 to 132 +/- 2.9 mm Hg caused significant increases in QDVR (from 4.7 +/- 0.9 to 5.5 +/- 0.9 nl/min, p < 0.001) and QAVR (from 2.8 +/- 0.2 to 3.5 +/- 0.2 nl/min, p < 0.001) in association with increases in RIHP (from 4.6 +/- 1.3 to 7.6 +/- 1.3 mm Hg, p < 0.001), urine flow (from 16.2 +/- 2.6 to 20.2 +/- 3.2 microliters.min-1 x g kidney wt-1, p < 0.01), and urinary s...
Responses of thoracic spinothalamic neurons to intracardiac injection of bradykinin in the monkey.
Authors: R WBlair, R NWeber, R DForeman
Journal: Circulation Research (1982)

Bradykinin stimulates afferent fibers arising in the heart and may be involved in the mediation of anginal pain and the pain associated with myocardial infarction. The sensation of pain requires that noxious information reach the brain. The purpose of the present study was to determine whether the spinothalamic tract is involved in transmitting noxious information from the heart to the brain. Bradykinin was injected (0.3-3.5 micrograms/kg) into the heart via a catheter in the left atrium while we recorded from single spinothalamic cells in the C8 to T5 spinal segments. Thirty-one of 41 cells responded to bradykinin. The responses of 12 cells were characterized by both an increase in discharge rate and entrainment of cell activity with the cardiac cycle. Eighteen cells responded with only an increased rate, and one cell exhibited only entrainment of cell activity with the cardiac cycle. The mean onset of increased cell activity occurred 15 seconds following drug injection, and the average duration of the r...
Efficacy and Safety of Eus-Guided Transmural Gallbladder Drainage In Malignant Biliary Obstruction Using an Electrocautery-Enhanced Lumen Apposing Metal Stent: a French Multicenter Study
Authors: T Lambin, J Branche, J Privat, JF Bourgaux, S Koch, M Palazzo, U Chaput, T Ponchon, M Pioche, P Grandval, R Gérard
Journal: Endoscopy (2021)

Aims In case of malignant obstruction of the distal biliary duct, electrocautery-enhanced lumen apposing metal stent (EC-LAMS) allows either endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) or choledochoduodenostomy (EUS-CDS) if endoscopic retrograde cholangiopancreatography (ERCP) is not feasible. EUS-CDS is associated with less adverse events than EUS-HGS but can be challenging. Thus, a simple alternative would be welcomed. We aim to assess the efficacy and safety of EUS-guided transmural gallbladder drainage using an EC-LAMS in malignant distal biliary obstruction.
Comment on: Wing et al. Effect of Intensive Lifestyle Intervention on Sexual Dysfunction in Women With Type 2 Diabetes: Results From an Ancillary Look AHEAD Study. Diabetes Care 2013;36:2937–2944
Authors: Maria Ida Maiorino, Michela Petrizzo, Giuseppe Bellastella, Katherine Esposito
Journal: Diabetes Care (2013)

We read with interest the article of Wing et al. (1) reporting the prevalence of sexual dysfunction in a group of obese women with type 2 diabetes and the effect of intensive lifestyle changes. The 50% prevalence of female sexual dysfunction (FSD) they found in 227 obese women appears conservative, at the least, which may lead to an underestimation of FSD prevalence in the sample. The choice to exclude sexually inactive women is questionable, as the direction of the association was not defined on an a priori basis: FSD might have been responsible for being sexually inactive. We found a 53.4% prevalence of FSD in a large population ( n = 595) of younger …
Time course and zonal variations of ischemia-induced myocardial cationic electrolyte derangements.
Authors: J TLie, P CPairolero, K EHolley, J TMcCall, H KThompson, J LTitus
Journal: Circulation (1975)

Myocardial cationic electrolytes were determined at regular time intervals up to 24 hours after coronary artery ligation in the dog. Replicate electrolyte ratios were computed for different areas of the heart at each time interval. For purposes of statistical analysis, ratios from two border areas and four areas remote from the infarct were pooled as values for ZONE B and ZONE N, respectively, and compared with those from the infarct proper, ZONE I. Ischemia-induced tissue Mg++/Ca++ changes paralleled those of K+/Na+ with respect to time course and zonal variations. In ZONE I, both K+/Na+ and Mg++/Ca++ fell precipitously during the first hour, and the falls became more gradual thereafter, approac hing those of extracellular fluid at 24 hours. Changes in ZONE B, which appeared normal histologically, followed a similar downward trend but differed in magnitude from those in ZONE I (P smaller than 0.01). Changes in ZONE N were small but did not always overlap values in sham-operated dogs. It was concluded tha...
Reply to: “Patient-reported symptoms during direct-acting antiviral treatment: A real-life study in HIV-HCV coinfected patients (ANRS CO13 HEPAVIH)”
Authors: Donna M. Evon, Souvik Sarkar, Jipcy Amador, Anna S. Lok, Richard K. Sterling, Paul W. Stewart, Bryce B. Reeve, Marina Serper, Nancy Reau, K. Rajender Reddy, Adrian M. Di Bisceglie, David R. Nelson, Carol E. Golin, Joseph K. Lim, Michael W. Fried
Journal: Journal of Hepatology (2019)
Pasireotide for postoperative pancreatic fistula.
Authors: Feng Yang, Chen Jin, Deliang Fu
Journal: New England Journal of Medicine (2014)

To the Editor: The study by Allen et al. (May 22 issue) 1 showed that pasireotide reduced the risk of clinically relevant pancreatic fistula after either pancreaticoduodenectomy or distal pancreatectomy, whether or not the pancreatic duct was dilated. It would be useful to provide details regarding the presence of a dilated duct or a soft pancreatic texture in the pancreaticoduodenectomy group, because they were risk factors for clinically relevant pancreatic fistula after pancreaticoduodenectomy but not after distal pancreatec
Genome-wide association study of serum metabolites in the African American Study of Kidney Disease and Hypertension
Authors: Shengyuan Luo, Elena V. Feofanova, Adrienne Tin, Sarah Tung, Eugene P. Rhee, Josef Coresh, Dan E. Arking, Aditya Surapaneni, Pascal Schlosser, Yong Li, Anna Köttgen, Bing Yu, Morgan E. Grams
Journal: Kidney International (2021)
Amiodarone and its desethyl metabolite: tissue distribution and morphologic changes during long-term therapy.
Authors: P CAdams, D WHolt, G CStorey, A RMorley, JCallaghan, R WCampbell
Journal: Circulation (1985)

The pharmacokinetic characteristics of amiodarone suggest extensive tissue deposition. We confirmed this by measuring tissue concentrations of the drug and of its major metabolite, desethylamiodarone, in human tissues. These were obtained at autopsy (n = 9), surgery (n = 7), or biopsy (n = 2) from 18 patients who had been treated with amiodarone for varying periods of time. High concentrations of amiodarone were found in fat (316 mg/kg wet weight in autopsy specimens, 344 mg/kg wet weight in biopsy specimens). Amiodarone and desethylamiodarone concentrations (mg/kg wet weight, autopsy samples) were also high in liver (391 and 2354), lung (198 and 952), adrenal gland (137 and 437), testis (89 and 470), and lymph node (83 and 316). We also found high concentrations of amiodarone (306 mg/kg wet weight) and desethylamiodarone (943 mg/kg wet weight) in abnormally pigmented (blue) skin from patients with amiodarone-induced skin pigmentation. These values were 10-fold higher than those in unpigmented skin from...
Enhancement of tactile perception in palpation.
Authors: DSmith, ECraige
Journal: Circulation (1980)

We studied tactile perception in palpation of the precordium to determine the frequency response of the hand and to improve, if possible, the sensitivity of the hand as a transducer for precordial movement. The threshold of tactile sensation was determined for 10 subjects by manipulating the amplitude of movement of an impulse generator at each of a series of frequency settings in the subaudible range (1-40 Hz.) Relatively gross movements were necessary to achieve threshold in the lowest frequencies. A more than four-fold increase in sensitivity was obtained by restraining the fingers with the application of a light but unyielding disc to their dorsal surface. Clinical application of this device permitted the easy perception of a systolic thrust as well as a rapid filling wave in normal adult subjects over the right ventricle at the left sternal edge, an area generally considered to be motionless by conventional palpation.
Angiotensin-converting enzyme activity and its modulation by oxygen tension in the guinea pig fetal-placental unit.
Authors: DDavidson, S AStalcup, R BMellins
Journal: Circulation Research (1981)

Angiotensin-converting enzyme (ACE) activity in the guinea pig fetal-placental unit was assessed at the different oxygen tensions found in utero, during labor, and at birth. To determine fetal-placental ACE activity, we separately perfused in situ term guinea pig fetuses and their placentas via the umbilical vessels under controlled conditions of flow, temperature, and pH. ACE activity was defined as the percent of angiotensin I (AO) or bradykinin (BK) in Krebs-Henseleit solution cleared by a single passage through the placenta or fetus. Peptide concentrations were measured by radioimmunoassay (RIA). Using BK as substrate, we found that placental and fetal ACE activities were reflected by 45% (SD = 10) and 24% (SD = 7) clearances, respectively, at a perfusate PO2 of 29 mm Hg. Maternal hypoxia (PaO2 = 28 mm Hg) decreased placental ACE activity to 16% (SD = 8) and maternal hyperoxia (PaO2 = 191 mm Hg) increased placental ACE activity to 56% (SD = 9). Using a perfusate PO2 of 95 mm Hg, fetal and placental AC...
Race, ethnicity, and comorbidities are critical factors in the diagnosis of telogen effluvium during the COVID-19 pandemic
Authors: Abigail Cline, Ashley Keyes Jacobs, Maira Fonseca, Julia Wu, Falguni Asrani, Bijan Safai, Sharon Glick, Beth N. McLellan, Amy J. McMichael, Shoshana Marmon
Journal: Journal of the American Academy of Dermatology (2021)
Common or single ventricle. An angiocardiographic and hemodynamic study of 42 patients.
Authors: F JMacartney, J BPartridge, OScott, P BDeverall
Journal: Circulation (1976)

To correlate anatomy with hemodynamics, the angiocardiographic findings were reviewed in 42 patients with common ventricle (CV). Nine had normally related great arteries (NRGA), 12 d-malposition, 21 l-malposition and 5 a common atrioventricular valve. Selective outlet chamber (OLC) angiocardiograms were available in 14 out of 29 patients with OLCs. OLC position varied from anterior and to the right of the CV to posterior and to the left of it; two categories (anterior and lateral OLC) were delineated by a line 45 degrees to theleft of anterior in the horizontal plane. The OLC was anterior in all patients with NRGA, lateral in most l-malpositions, and almost equally divided between anterior and lateral in d-malposition (P less than 0.05). Complete hemodynamic data were obtained in 29 patients. Complete mixing of venous return occurred in four patients with atresia of one valve. In the remainder complete mixing occurred in 36%, unfavorable streaming in 12% and favorable streaming in 52%. Semilunar valve pos...
Abstract P193: Metabolomic Profiles Associated With Longevity Women
Authors: Raji Balasubramanian, Nina Paynter, Franco Giulianini, JoAnn E Manson, JC Chen, Mara Z Vitolins, Clary Clish, Christine A Albert, Kathryn M Rexrode
Journal: Circulation (2017)

Background: Identifying metabolite profiles associated with longevity may identify key pathways of healthy aging. The Framingham Heart Study previously identified 12 metabolites associated with longevity, but no studies have examined women specifically. Methods: Of 2306 women in the Women’s Health Initiative (WHI) without known cardiovascular disease and with metabolomic profiles at baseline (1993-1998), 1386 were age 63 or older (potentially able to achieve age 85 years in 2015), and were not lost to follow-up before death or age 85. Liquid chromatography mass spectroscopy was used to measure metabolites, which were log-transformed and standardized. The 12 candidate metabolites were considered individually in logistic regression models to predict odds of attaining longevity (age ≥ 85): isocitrate, uridine, lysine, aconitate, histidine, malate, threonine, cotinine, C22:6 lysophophatidylcholine (LPC) and C38:6 phoshatidylcholine (PC). Models were initially adjusted for WHI arm and age (model 1), then additionally for baseline BMI, systolic blood pressure, hypertension, diabetes, smoking, total and HDL cholesterol (model 2). An FDR-adjusted p value &lt;0.05 was defined as significant.Significant metabolites were all considered in a backward selection procedure (p for exclusion &gt; 0.05). A composite score of these significant mutually-adjusted metabolites was created based on the quartile score for each metabolite, with higher values indicating higher likelihood of achieving longevity. Results: The median baseline age was 71 years (range 63-79), and 712 women reached age ≥ 85. Ten of the 12 previously identified metabolites were significantly associated with longevity in this cohort in model 1; 8 remained significant in model 2 (FDR &lt;0.05). When all 10 metabolites were considered together in a model and subjected to backwards selection, 3 remained significantly associated with longevity in model 2 (OR per SD [95% CI]): isocitrate (0.80 [0.70-0.91]) a substrate of the citric acid cycle, uridine (1.18 [1.04-1.34]) one of the five nucleosides making up nucleic acids, and lysine (1.24 [1.09-1.40]) an amino acid used in the biosynthesis of proteins. Women in the highest quartile of the 3 metabolite score had an OR of 2.24 (95% CI: 1.60-3.15) for longevity, compared to those in the lowest quartile of the score, after multivariate adjustment. Results for the score were significant for women both above and below the median age. For women &lt;71 years, the highest score quartile was associated with an OR of 3.57 (2.22-5.76) for longevity, compared to the lowest. Conclusions: Eight metabolites were found to be significantly associated with attaining longevity among women in the WHI. A score comprised of isocitrate, uridine and lysine was associated with a 2-3-fold higher odds of attaining longevity. Further research to understand the mechanisms between these metabolites and longevity is needed.
Mechanisms of sinoatrial pacemaker synchronization: a new hypothesis.
Authors: D CMichaels, E PMatyas, JJalife
Journal: Circulation Research (1987)

A model of electrically coupled sinus node cells was used to investigate pacemaker coordination and conduction. Individual cells were simulated using differential equations describing transmembrane ionic currents. Intrinsic cycle lengths (periods) were adjusted by applying constant depolarizing or hyperpolarizing bias current, and cells were coupled through ohmic resistances to form two-dimensional arrays. Activation maps of 81-225 coupled cells showed an apparent wavefront conducting from a leading pacemaker region to the rest of the matrix even though the pattern actually resulted from mutual entrainment of all spontaneously beating cells. Apparent conduction time increased with increasing intercellular resistance. Appropriate selection of pacemaker cycle lengths and intercellular resistances permitted the accurate simulation of the activation sequence seen experimentally for the rabbit sinus node. Furthermore, a simulated acetylcholine pulse applied to a randomly selected 20% of the cells in this model...
Comparison of dextran and hematocrit effects in the pulmonary microcirculation.
Authors: J URaj, JAnderson
Journal: Circulation Research (1991)

We have compared the effects of an increase in perfusate viscosity induced by dextran and by hematocrit (Hct) on segmental vascular resistance in the pulmonary circulation and the effect of flow on microvascular resistance in lungs perfused with dextran and red blood cells. We isolated and perfused lungs of 39 neonatal rabbits weighing 670 +/- 250 g. To determine the effect of dextran, group 1 (n = 8) lungs were perfused with both 5% and 20% dextran 70 solutions (Hct, approximately 25%); to determine the effect of Hct, group 2 (n = 5) lungs were perfused alternately with 5% and 40% Hct solutions (5% dextran 70). In group 1 and group 2 lungs, experiments were done at constant flow and pressure. Group 3 and group 4 (each n = 4) lungs were perfused with 5% and 20% dextran 70, respectively (0 Hct); group 5 (n = 5), with 10% dextran 70; group 6 (n = 7), with 5% dextran 500; and group 7 (n = 6), with 20% dextran 70 (Hct, approximately 5%). All lungs were perfused in zone 3; airway and left atrial pressures were...
Symptoms of Anxiety or Depressive Disorder and Use of Mental Health Care Among Adults During the COVID-19 Pandemic — United States, August 2020–February 2021
Authors: Anjel Vahratian, Stephen J. Blumberg, Emily P. Terlizzi, Jeannine S. Schiller
Journal: MMWR Morbidity and Mortality Weekly Report (2021)

From August 2020-February 2021, adults with recent symptoms of an anxiety or depressive disorder increased from 36% to 42%. Increases were largest among adults 18–29 years and those with less than a high school education.
Comparison of the electrocardiographic changes induced by maximam exercise testing with treadmill and cycle ergometer.
Authors: J RWicks, J RSutton, N BOldridge, N LJones
Journal: Circulation (1978)

Maximum exercise testing using treadmill walking and cycle ergometry was compared in 40 male patients who had suffered a myocardial infarction in the preceeding twelve months. Maximum oxygen uptake was on average 17% greater in the treadmill than the cycle test and maximum heart rate was also higher, but the rate pressure product (RPP) was a similar due to a higher blood pressure in the cycle ergometer test. Eleven subjects showe ST-segment depression greater than 1 min and eight subjects showed ST-segment elevation greater than 1 mm. There was a close relationship (r2 = 0.96) between the magnitude of ST-segment changes in the two tests. Four subjects showing ST depression of 1 mm in the treadmill test showed depression during the cycle ergometer test which was less than this conventionally positive value. In these subjects RPP was lower during cycling than in treadmill walking. With both tests maximum ST-segment changes were measured immediately on stopping exercise: resolution of ST depression was mor...
Adult Blood Lead Epidemiology and Surveillance—United States, 2002
Authors: N Brener, R Lowry, L Bar- Rios
Journal: JAMA (2004)

1993 to 12.8% in 2003.A similar significant linear trend was detected among all subgroups.No significant changes were detected in the prevalence of being threatened or injured with a weapon on school property during 1993-2003 overall or among female, male, Hispanic, 10th-, and 12th-grade students.A significant linear increase during 1993-2003 was detected among white and 9th-grade students.Among black students, being threatened or injured with a weapon on school property declined during 1993-1999 and then increased through 2003.Among 11th-grade students, being threatened or injured with a weapon on school property declined during 1993-1999 and then remained level through 2003.Not going to school because of safety concerns increased significantly, from 4.4% in 1993 to 5.4% in 2003.Not going to school because of safety concerns also increased significantly among female, white, and 11th-grade students.No significant changes were detected during 1993-2003 among male, black, Hispanic, 9th-, 10th-, and 12thgrade students.
Infant pacifier sanitization and risk of challenge-proven food allergy: A cohort study
Authors: Victoria X. Soriano, Jennifer J. Koplin, Mike Forrester, Rachel L. Peters, Martin O’Hely, Shyamali C. Dharmage, Rosemary Wright, Sarath Ranganathan, David Burgner, Kristie Thompson, Terence Dwyer, Peter Vuillerman, Anne-Louise Ponsonby
Journal: Journal of Allergy and Clinical Immunology (2021)
TCTAP C-011 PCI To CTO ISR LAD In Acute Anterior Myocardial Infarction: Lifesaving Angioplasty For A Patient With Severe Triple Vessel Disease Unsuitable For CABG
Authors: Khai Chih Teh, Ahmad Khairuddin Mohamed Yusof, Amin Ariff Nuruddin
Journal: Journal of the American College of Cardiology (2021)
Abortion law reform.
Authors: J Bury
Journal: BMJ (1978)

The 1967 Abortion Act in England requires that a woman have two doctors' signatures before she can obtain an abortion. Various groups, such as Doctors for a Woman's Choice on Abortion, are working to change the law to abortion on request. If the law were changed there would be fewer delays before termination. In countries with abortion on request, 90% are performed in the first trimester. Under the existing law, 80% are first trimester. The decrease in the number of conceptions in England and Wales since 1968 indicates that liberal abortion laws encourage greater use of contraception. No one is forced to do anything against his or her will--neither the woman nor the doctor.
Chemically determined mineral content of explanted porcine aortic valve bioprostheses: correlation with radiographic assessment of calcification and clinical data.
Authors: F JSchoen, J LKujovich, C LWebb, R JLevy
Journal: Circulation (1987)

Bioprosthetic valve calcification is usually assessed pathologically by gross inspection, radiographic studies, and histologic examination. Quantitation of mineral content by chemical assay has not been reported for failed clinical valves removed from adults. In this study, calcium determination by atomic absorption spectroscopy was done on 52 removed porcine valves after routine pathologic examination, including specimen radiography done by a standard technique. Specimens included 31 valves with calcific primary tissue failure, two calcified (but not overtly dysfunctional) valves removed simultaneously with failed valves, 14 nondeteriorated valves obtained at reoperation or autopsy after long-term implantation, and five valves removed within 1 month after insertion. Chemically determined mineral content varied widely among patients and duration of function. Valves with calcific failure had 113 +/- 68 micrograms/mg calcium overall (mean +/- SD) after 36 to 156 months (mean 87) of function. Almost all dysf...
Angiotensin II modulates cardiac Na+ channels in neonatal rat.
Authors: J RMoorman, G EKirsch, A ELacerda, A MBrown
Journal: Circulation Research (1989)

Since chronic congestive heart failure syndromes are associated with both elevated circulating levels of angiotensin II and potentially lethal ventricular tachyarrhythmias, we investigated the effect of angiotensin II on voltage-dependent cardiac Na+ currents. Single-channel Na+ currents in neonatal rat ventricular myocytes were studied using the patch clamp method in the cell-attached mode. Angiotensin II applied outside the patch increased the frequency of opening and rates of activation and inactivation of single-channel Na+ currents within the patch. These effects were mimicked by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) and were prevented by prior incubation with TPA. Therefore, we propose that angiotensin II modulates cardiac Na+ currents by a cytoplasmic second messenger, perhaps protein kinase C, and this may predispose toward arrhythmia.