tbuckley/cabot-search huggingface dataset:
Patient's Experiences in a Medicalized Hotel for Covid-19 Acute Care Support. An Observational Study with a Cross-Sectional Design
Authors: A. B. Negre, M. Cervera, J. Escarrabill, E. Palou, A. Carbonell, N. Seijas, D. Nicolas, F. Feu, C. Hernandez
Journal: American Journal of Respiratory and Critical Care Medicine (2021)

On 11th March 2020, the novel coronavirus Covid-19 was declared a pandemic by the World Health Organization. The 14th of March, the Spanish government declared the State of Emergency. Urgent reorganization was required to give answers to the needs of this new illness. The number of patients admitted grew exponentially and resources were insufficient to care for such a number of people at home. The Hospital at Home (HaH) was called to transform a hotel into a medicalized healthcare space. The Medicalized Hotel wanted to solve three needs: grouping patients, providing more beds and allowing the isolation. Current health policy emphasizes on patient experience as one of the key components of quality of care. Patients must be involved in decision-making about their heath situation and treatment in order to provide an integrated healthcare. Analyzing patients' experience will provide knowledge and will allow finding out if the Medicalized Hotel was a good alternative. Aim: To assess the patient experience during hospital admission in a Medicalized Hotel for COVID-19, from 25th March to 15th May, and variables that may influence these experiences. Methods: Observational and descriptive study with a cross-sectional design. The study population (n=517) consisted of patients admitted in Medicalized Hotel who met inclusion criteria. Patient experience collected by the Picker Patient Experience questionnaire, PPE-15 (translated to Catalan and Spanish) and four open questions analyzed in a qualitative way. Other variables: Socio-demographic and review clinical records. Results: 427 patients (83% of admitted) answered the questionnaire (52% male, 55 yrs (63%)). Main results: being treated with respect and dignity (95%), receiving similar information from different professionals (84%) and getting understanding answers by doctors and nurses (79%, 86%). 52% of participants identified no areas for improvement and <25% of improvement areas were related to food quality and communication difficulties, due to pandemic isolation measures. These contributions enhanced in: creating a clean and dirty area;improve the welcome material reception and documented information on discharge;activities for patients, such as a library, app and mobiles. Conclusions: The Medicalized Hotel, led by the HaH team, was a safe and effective alternative to acute hospital care. Grouping patients together increased HaH's effectiveness and prevented the Hospital's collapse during pandemia. Patients' experiences have been highly positive and contributed to form the medicalized hotel. With further validation, this study may be used by health professionals and organizations to improve healthcare and enhance patient experience.
IgD Myeloma: Clinical Features and Outcome from a Multicenter Retrospective Study in Chinese and Korean of 308 Patients from Asian Myeloma Network (AMN) Project
Authors: Juan Du, Weijun Fu, Jae Hoon Lee, Chunyang Zhang, Kihyun Kim, Ai Jun Liu, Jin Lu, Cheolwon Suh, Min Kyoung Kim, Wenming Chen, Jin Liu, Hua Jiang, Jian Hou
Journal: Blood (2017)
Abstract 312: Arterial CEPT1 Expression Correlates With Diabetes and Atherosclerotic Occlusive Disease
Authors: Mohamed A Zayed, Uzma Naim, Kyoung-mi Park, Larisa Belaygorod, Clay Semenkovich
Journal: Circulation Research (2016)

Choline/ethanolamine phosphotransferase-1 (CEPT1) is a ubiquitously expressed enzyme that catalyzes the final step in synthesis of the majority of mammalian phospholipids, that are known to also impact atheroprogression. We previously found that in the setting of diabetes CEPT1 expression and downstream phospholipid biosynthesis are critically altered in hepatocytes. We therefore hypothesized that in diabetes CEPT1 expression is also altered in arterial tissue, and correlates with disease severity. To test this hypothesis we evaluated CEPT1 protein expression in murine and human arterial tissue in the presence or absence of diabetes, and/or advanced occlusive disease. CEPT1 expression in the aorta of Db/Db mice was 43% increased relative to Wt controls (n=7 per mouse group;p=0.03). On the other hand, CEPT1 expression was not significantly altered in Db/Db myocardial or skeletal muscle (p=0.2 and p=0.09, respectively). To determine whether our findings translate to similar CEPT1 expression patterns in human arterial tissue, we harvested carotid artery intima from 11 diabetic and 7 non-diabetic patients undergoing carotid endarterectomy (CEA). We also harvested peripheral arterial segments with minimal and maximal atherosclerotic occlusive disease from 8 diabetic and 4 non-diabetic patients undergoing lower extremity amputation. Relative to non-diabetic patients, patients who were diabetic had increased CEPT1 expression in CEA tissue (53% increase;p=0.05), and peripheral arterial segments (36% increase;p=0.04). Interestingly, relative to peripheral arteries with minimal atherosclerotic occlusive disease, segments with maximal disease had a two-fold increase in CEPT1 expression (p&lt;0.01). Analysis of maximally diseased peripheral arteries demonstrated significantly higher CEPT1 expression among diabetic patients (34% increase;p=0.03). There was no difference in CEPT1 expression in minimally diseased arteries of diabetic and non-diabetic patients (p=0.1). These findings highlight that increased CEPT1 expression correlates with diabetes and extent of arterial occlusive disease. Furthermore, they argue that CEPT1 is a unique arterial tissue biomarker for occlusive disease severity.
Abstract 12826: Prognostic Significance of Serum Cholinesterase Level in Patients With Reduced, Mid-Range and Preserved Left Ventricular Ejection Fraction With Acute Decompensated Heart Failure: A Prospective Study in Osaka Prefectural Acute Heart Failure Registry (OPAR)
Authors: Masahiro Seo, Takahisa Yamada, Takashi Morita, Yoshio Furukawa, Shunsuke Tamaki, Yusuke Iwasaki, Masato Kawasaki, Atsushi Kikuchi, Tsutomu Kawai, Makoto Abe, Jun Nakamura, Kyoko Yamamoto, Kiyomi Kayama, Masatsugu Kawahira, Kazuya Tanabe, Masatake Fukunami
Journal: Circulation (2018)

Backgrounds: We previously reported that serum cholinesterase (CHE) level, which reflect various factors such as hepatic function, inflammation and nutritional status, was a robust independent prog...
Extracellular DEK Regulates Hematopoiesis through CXCR2-Mediated Intracellular Signaling That Does Not Require Its Translocation into the Nucleus or Binding to DNA
Authors: Maegan Capitano, Nirit Mor-Vaknin, Maureen Legendre, Scott Cooper, Ferdinand Kappes, David Markovitz, Hal E. Broxmeyer
Journal: Blood (2017)
Cardiac sequelae after coronavirus disease 2019 recovery: a systematic review
Authors: Mohammad Said Ramadan, Lorenzo Bertolino, Rosa Zampino, Emanuele Durante-Mangoni, Emanuele Durante-Mangoni, Domenico Iossa, Lorenzo Bertolino, Maria Paola Ursi, Fabiana D'Amico, Arta Karruli, Mohammad Ramadan, Roberto Andini, Rosa Zampino, Mariano Bernardo, Giuseppe Ruocco, Giovanni Dialetto, Franco Enrico Covino, Sabrina Manduca, Alessandro Della Corte, Marisa De Feo, Stefano De Vivo, Maria Luisa De Rimini, Nicola Galdieri
Journal: Clinical Microbiology and Infection (2021)
New solutions for combatting implant bacterial infection based on silver nano-dispersed and gallium incorporated phosphate bioactive glass sputtered films: A preliminary study
Authors: B.W. Stuart, G.E. Stan, A.C. Popa, M.J. Carrington, I. Zgura, M. Necsulescu, D.M. Grant
Journal: Bioactive Materials (2021)

Ag/Ga were incorporated into resorbable orthopaedic phosphate bioactive glasses (PBG, containing P, Ca, Mg, Na, and Fe) thin films to demonstrate their potential to limit growth of Staphylococcus aureus and Escherichia coli in post-operative prosthetic implantation. Dual target consecutive co-sputtering was uniquely employed to produce a 46 nm Ag:PBG composite observed by high resolution TEM to consist of uniformly dispersed ~5 nm metallic Ag nano-particles in a glass matrix. Ga3+ was integrated into a phosphate glass preform target which was magnetron sputtered to film thicknesses of ~400 or 1400 nm. All coatings exhibited high surface energy of 75.4–77.3 mN/m, attributed to the presence of hydrolytic P–O–P structural surface bonds. Degradation profiles obtained in deionized water, nutrient broth and cell culture medium showed varying ion release profiles, whereby Ga release was measured in 1400 nm coating by ICP-MS to be ~6, 27, and 4 ppm respectively, fully dissolving by 24 h. Solubility of Ag nanoparticles was only observed in nutrient broth (~9 ppm by 24 h). Quantification of colony forming units after 24 h showed encouraging antibacterial efficacy towards both S. aureus (4-log reduction for Ag:PBG and 6-log reduction for Ga-PBG≈1400 nm) and E. coli (5-log reduction for all physical vapour deposited layers) strains. Human Hs27 fibroblast and mesenchymal stem cell line in vitro tests indicated good cytocompatibility for all sputtered layers, with a marginal cell proliferation inertia in the case of the Ag:PBG composite thin film. The study therefore highlights the (i) significant manufacturing development via the controlled inclusion of metallic nanoparticles into a PBG glass matrix by dual consecutive target co-sputtering and (ii) potential of PBG resorbable thin-film structures to incorporate and release cytocompatible/antibacterial oxides. Both architectures showed prospective bio-functional performance for a future generation of endo-osseous implant-type coatings.
Design of Protein‐Based Liquefied Cell‐Laden Capsules with Bioinspired Adhesion for Tissue Engineering
Authors: Maria C. Gomes, Dora C. S. Costa, Cláudia S. Oliveira, João F. Mano
Journal: Advanced Healthcare Materials (2021)

Abstract Platforms with liquid cores are extensively explored as cell delivery vehicles for cell‐based therapies and tissue engineering. However, the recurrence of synthetic materials can impair its translation into the clinic. Inspired by the adhesive proteins secreted by mussels, liquefied capsule is developed using gelatin modified with hydroxypyridinones (Gel‐HOPO), a catechol analogue with oxidant‐resistant properties. The protein‐based liquefied macrocapsule permitted the compartmentalization of living cells by an approachable and non‐time‐consuming methodology resorting to i) superhydrophobic surfaces as a processing platform of hydrogel beads, ii) gelation of gelatin at temperatures &lt; 25 °C, iii) iron coordination of the hydroxypyridinone (HOPO) moieties at physiological pH, and iv) core liquefaction at 37 °C. With the design of a proteolytically degradable shell, the possibility of encapsulating human adipose‐derived mesenchymal stem cells (hASC) with and without the presence of polycaprolactone microparticles ( μ PCL) is evaluated. Showing prevalence toward adhesion to the inner shell wall, hASC formed a monolayer evidencing the biocompatibility and adequate mechanical properties of these platforms for proliferation, diminishing the need for μ PCL as a supporting substrate. This new protein‐based liquefied platform can provide biofactories devices of both fundamental and practical importance for tissue engineering and regenerative medicine or in other biotechnology fields.
Abstract 379: The Prognostic Value of Eosinophil to Leukocyte Ratio in Patients Presenting With ST-elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Authors: Takao Konishi, Naohiro Funayama, Tadashi Yamamoto, Daisuke Hotta
Journal: Circulation Research (2016)

Background: Elevated neutrophil to leukocyte ratio in patients with ST-segment elevation myocardial infarction (STEMI) is associated with adverse clinical outcomes. However, whether decreased eosinophil ratio after primary percutaneous coronary intervention (PCI) reflects larger infarct size has not been fully investigated. This study examined the relationship between eosinophil ratio and creatinine kinase-MB (CK-MB) elevation after primary PCI in patients presenting with STEMI. Methods and Results: We analyzed the data of 321 consecutive patients who underwent primary PCI for ST-elevation myocardial infarction between January 2009 and August 2015. Total and each type of leukocyte counts 24 hours after admission were measured. The eosinophil/leukocyte ratio (ER) was calculated as the ratio of eosinophil to leukocyte count. The primary end point was major adverse cardiac event (MACE) and the follow-up period was 180 days. The mean ER and max CK-MB was 0.44±0.65 % and 217.3±224.4 IU/l, respectively. ER obtained 24 hours after admission was inversely correlated with CK-MB concentration (r=-0.37, r2=0.14, P&lt;0.001). MACE within 180 days occurred in 68 patients (21%) including death (9%), myocardial infarction (MI) (1%) and target lesion or vessel revascularization (10%). Patients who had MACE within 180 days had lower ER (0.20±0.51 vs 0.49±0.66, P&lt;0.001) at 24 hours after admission. Conclusions: The decreased ER after primary PCI in patients presenting with STEMI was associated with increased CK-MB concentration, which might indicate larger infarct size, therefore, poor prognosis.
短報: タンパク質Sによるその活性化促進に必要なTFPI Kunitzドメイン3における機能的に重要な残基の同定
Authors: Ahnstroem Josefin, M Andersson Helena, Hockey Verity, Meng Yiran, A J Mckinnon Thomas, Hamuro Tsutomu, T B Crawley James, A Lane David
Journal: Blood (2012)
Abstract 420: Comparison of Prognostic Predictors After Return of Spontaneous Circulation Between Cardiac and Non-Cardiac Cardiopulmonary Arrest
Authors: Kenta Ohmure, Masaaki Miyata, Kento Tagata, Tatsuo Yokomine, Yuutaro Nomoto, Shunichi Imamura, Mariko Kawasoe, Hideto Chaen, Naoya Oketani, Masakazu Ogawa, Mitsuru Ohishi
Journal: Circulation (2019)

Introduction: Understanding the characteristics of survivor after return of spontaneous circulation (ROSC) in patients with cardiopulmonary arrest (CPA) may help us to select the optimal management. Hypothesis: We hypothesized that the prognosis and predictors of survivor after ROSC could be different between cardiac and non-cardiac CPA patients. Method: We retrospectively analyzed consecutive 85 patients with CPA and ROSC after cardiopulmonary resuscitation (CPR) in our hospital and divided them into cardiogenic (n=35) and non-cardiogenic (n=50) CPA. We analyzed age, gender, bystander CPR, duration of CPA, pupil diameter at admission, Glasgow coma scale, total protein (TP) level, creatinine level, pH of arterial blood and death in hospital. Result: The 17 patients died in cardiogenic CPA and 40 patients in non-cardiogenic CPA. The Kaplan-Meier curve demonstrated the better prognosis in cardiogenic CPA compared with non-cardiogenic CPA (Figure). In both CPA, duration of CPA was shorter and total TP level was higher in survival than those in dead group. In cardiogenic CPA, age was younger and creatinine level was lower in survival group compared with dead group (Table). In non-cardiogenic CPA, pupil diameter was smaller in survival group compared with dead group. Furthermore, in TP levels, the receiver operating characteristic (ROC) curve for survival after ROSC demonstrated that the area under curve (AUC) was 0.82 and provided an optimal cut-off value at 6.2 mg/dl of TP with 71% sensitivity and 83% specificity. In non-cardiogenic CPA, ROC curve demonstrated that AUC was 0.73 and 59% sensitivity, and 100% specificity at the optimal cut-off value of TP 6.0 mg/dl. Therefore, TP levels may be the better prognostic predictor in cardiogenic CPA compared with non-cardiogenic CPA. Conclusion: Although duration of CPA and TP levels were common predictor for survival after ROSC in CPA, there were different prognostic predictors in cardiogenic or non-cardiogenic CPA.
A prototype closed-loop brain–machine interface for the study and treatment of pain
Authors: Qiaosheng Zhang, Sile Hu, Robert Talay, Zhengdong Xiao, David Rosenberg, Yaling Liu, Guanghao Sun, Anna Li, Bassir Caravan, Amrita Singh, Jonathan D. Gould, Zhe S. Chen, Jing Wang
Journal: Nature Biomedical Engineering (2021)
The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity
Authors: Shoubao Ma, Jiazhuo Yan, Tasha Barr, Jianying Zhang, Zhenhua Chen, Li-Shu Wang, Joseph C. Sun, Jianjun Chen, Michael A. Caligiuri, Jianhua Yu
Journal: The Journal of Experimental Medicine (2021)

N 6-methyladenosine (m6A) is the most prevalent posttranscriptional modification on RNA. NK cells are the predominant innate lymphoid cells that mediate antiviral and antitumor immunity. However, whether and how m6A modifications affect NK cell immunity remain unknown. Here, we discover that YTHDF2, a well-known m6A reader, is upregulated in NK cells upon activation by cytokines, tumors, and cytomegalovirus infection. Ythdf2 deficiency in NK cells impairs NK cell antitumor and antiviral activity in vivo. YTHDF2 maintains NK cell homeostasis and terminal maturation, correlating with modulating NK cell trafficking and regulating Eomes, respectively. YTHDF2 promotes NK cell effector function and is required for IL-15-mediated NK cell survival and proliferation by forming a STAT5-YTHDF2 positive feedback loop. Transcriptome-wide screening identifies Tardbp to be involved in cell proliferation or survival as a YTHDF2-binding target in NK cells. Collectively, we elucidate the biological roles of m6A modifications in NK cells and highlight a new direction to harness NK cell antitumor immunity.
Abstract 10437: Impact of Pulmonary Arterial Hypertension on Heart Failure With Preserved Ejection Fraction: Analysis From the National Inpatient Sample
Authors: Dipesh Ludhwani, Mohammad Kizilbash, Raj Patel, Chunyi Wu
Journal: Circulation (2019)

Introduction: Heart failure with preserved ejection fraction (HFpEF) constitutes more than half of the heart failure (HF) population. Coronary artery disease, age, diabetes among other increases mo...
Acute Myeloid Leukemia (AML) Patients with an Isolated Trisomy Display Increased Frequency of Spliceosome Mutations
Authors: Bhavana Bhatnagar, Ann-Kathrin Eisfeld, Krzysztof Mrózek, Jessica Kohlschmidt, Deedra Nicolet, Jonathan E. Kolitz, Bayard L. Powell, John C. Byrd, Clara D. Bloomfield
Journal: Blood (2017)
Detection of Clonal Hematopoiesis Is a Rare Event in Patients with Dyskeratosis Congenita
Authors: Martin Kirschner, Angela Maurer, Marcin W. Wlodarski, Monica Sofia Ventura Ferreira, Anne-Sophie Bouillon, Wolfgang Blau, Michael Kreuter, Martin Rosewich, Selim Corbacioglu, Joachim Beck, C. Matthias Wilk, Steffen Koschmieder, Fabian Beier, Tim H. Brummendorf
Journal: Blood (2017)
Abstract 27: Interplay of Prostaglandin E2 and Major Histocompatibility Comeplex-II Determines Immunoprivilege of Allogeneic Mesenchymal Stem Cells in the Ischemic Heart
Authors: Niketa Sareen, Glen Lester Sequiera, Ejlal Abu Al-Rub, Meenal Moudgil, Sanjiv Dhingra
Journal: Circulation Research (2016)

The unique immunomodulatory properties of bone marrow derived allogeneic mesenchymal stem cells (MSCs) make them excellent candidate cell type for clinical applications. The outcome of preclinical studies and initial clinical trials suggested that after transplantation to the infarcted heart, allogeneic MSCs were able to improve cardiac function. However the long term fate of transplanted cells in these studies was not determined. We recently reported that allogeneic MSCs improved heart function after implantation in the infarcted heart. However, late after implantation, transplanted cells lost their immunoprivilege, and were rejected. Therefore we started extensive investigations to study the mechanisms of rejection. Our data demonstrate that MSC immunoprivilege was found to be mediated by prostaglandin E2 (PGE2), the levels of this soluble factor decreased in rat MSCs after exposure to hypoxia/ischemic conditions which was associated with loss of immunoprivilege and rejection of transplanted allogeneic MSCs. We observed increased cytotoxicity in hypoxic MSCs caused by allogeneic T cells in the in vitro co-culture. Furthermore, blocking PGE2 biosynthesis in normoxic MSCs increased the immunogenicity of MSCs. MSCs immunoprivilege is reported to be established by the absence of major histocompatibility complex class II (MHC-II) molecules. Our data suggest that MHC-II expression increased in MSCs after exposure to hypoxia. PGE2 treatment of hypoxic MSCs decreased MHC-II expression and preserved their immunoprivilege. In a rat myocardial infarction (MI) model, maintaining PGE2 levels with a biodegradable, temperature sensitive hydrogel in the infarct region prevented rejection of transplanted allogeneic MSCs and restored cardiac function after five weeks of cell transplantation. In conclusion, immunoprivilege of allogeneic MSCs was maintained by PGE2 mediated regulation of MHC-II levels, exposure to hypoxia/ischemia decreased PGE2 and increased MHC-II levels that was associated with loss of immunoprivilege and rejection of MSCs. Maintaining PGE2 levels preserved immunoprivilege and restored cardiac function after an MI.
A Text-Book of Surgical Principles and Surgical Diseases of the Face, Mouth and Jaws. For Dental Students.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Four Stages in Social Media Network Analysis—Building Blocks for Health-Related Digital Autonomy in Artificial Intelligence, Social Media, and Depression
Authors: Carol G. Gu, Elizabeth Lerner Papautsky, Andrew D. Boyd, John Zulueta
Journal: The American Journal of Bioethics (2021)

This article refers to:Artificial Intelligence, Social Media and Depression. A New Concept of Health-Related Digital Autonomy