Legionnaires' Disease: Diagnosis and Management
Journal: Annals of Internal Medicine (1978)

Diagnosis and Treatment1 March 1978Legionnaires' Disease: Diagnosis and ManagementAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-3-363 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail AbstractAbstractLegionnaires' disease, an acute bacterial infection commonly manifested as pneumonia, has recently been recognized in outbreaks and sporadic cases. Most documented cases have occurred during the summer and in middle-aged or older persons. Clues to the diagnosis include nonproductive cough, pleuritic chest pain, diarrhea, and confusion. Moderate leukocytosis and nodular consolidation typically are seen on chest roentgenograms. Diagnosis may be made by culture of the fastidious Gram-negative bacillus from lung tissue or pleural fluid, demonstration of the organism in lung tissue by the direct fluorescent antibody technique, or documentation of a significant rise in serum titer by indirect fluorescence. Erythromycin is recommended for therapy.References1. FRASERTSAIORENSTEINPARKINBEECHAMSHARRARHARRISMALLISONMARTINMCDADESHEPARDBRACHMAN DTWWHRJGSJCP: Legionnaires' disease. Description of an epidemic of pneumonia. N Engl J Med 297:1189-1197, 1977 CrossrefMedlineGoogle Scholar2. MCDADESHEPARDFRASERTSAIREDUSDOWDLE JCDTMW: Legionnaires' disease. Isolation of a bacterium and demonstration of its role in other respiratory disease. N Engl J Med 297:1197-1203, 1977 CrossrefMedlineGoogle Scholar3. CHANDLERHICKLINBLACKMON FMJ: Demonstration of the agent of Legionnaires' disease in tissue. N Engl J Med 297:1218-1220, 1977 CrossrefMedlineGoogle Scholar4. MOSSWEAVERDEESCHERRY CRSW: Cellular fatty acid composition of isolates from Legionnaires' disease. J Clin Microbiol 6:140-143, 1977 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: ▸From the Center for Disease Control, Public Health Service, U.S. Department of Health, Education, and Welfare; Atlanta, Georgia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDelay in appropriate therapy ofLegionella pneumonia associated with increased mortalityUtility of Radiography and Clinical Features in the Diagnosis of Community-Acquired PneumoniaLegionnaires’ DiseaseUnusual progression of a Legionella pneumophila infection in a young childThe protean manifestations of Legionnaires' diseaseLegionnaires' diseasePulmonary Aspects of AgingErythromycinLung biopsy in immunocompromised patients: One institution's experience and an approach to management of pulmonary disease in the compromised hostLegionnaires' Disease Imported to Denmark from ItalyLegionnaires' disease in renal transplant patientsBacterial Pathogenicity, an OverviewThe Genus LegionellaAntimicrobial Treatment of Legionella PneumoniaLegionnaires’ lung abscessLegionnaires' diseaseRadiographic Features of Legionnaires Disease‘Legionellosis’ - doubts and certaintiesThe atypical pneumoniasPulmonary Diseases: An Annotated Bibliography of Recent Literature References to Journal Articles and Other PapersA Fatal Case of Legionnaire's Disease following a Total LaryngectomyClinical Aspects of Legionnaires' DiseaseMORTON N. SWARTZ, M.D.Immunology and Immunopathology of Legionnaires' DiseasePETER A. WARD, M.D.Comparative Features of Pneumococcal, Mycoplasmal, and Legionnaires' Disease PneumoniasCHARLES M. HELMS, M.D., Ph.D., JOHN P. VINER, M.D., RANDALL H. STURM, M.D., EDWARD D. RENNER, Ph.D., WILLIAM JOHNSON, Ph.D.Pulmonary Sequelae of Acute Legionnaires' Disease PneumoniaJOHN A. BLACKMON, M.D., RUSSELL A. HARLEY, M.D., MARTIN D. HICKLIN, M.D., FRANCIS W. CHANDLER, D.V.M., Ph.D.Ultrastructure of the Legionnaires' Disease Bacterium A Study Using Transmission Electron MicroscopyF. W. CHANDLER, D.V.M., Ph.D., R. M. COLE, Ph.D., M.D., M. D. HICKLIN, M.D., M.P.H., J. A. BLACKMON, M.D., C. S. CALLAWAY, B.S.Current status of laboratory diagnosis of legionnaires' diseaseLegionnaires' Disease Presenting with EmpyemaDiagnosis of viral disease and the advent of antiviral drugsISOLATION OF A NEW SEROTYPE OF LEGIONNAIRES' DISEASE BACTERIUMDiagnosis of Legionnaires' Disease from Transtracheal Aspirate by Direct Fluorescent-Antibody Staining and Isolation of the BacteriumLegionnaires' Disease: Clinical Features of 24 CasesBARBARA D. KIRBY, M.D., KIM M. SNYDER, M.D., RICHARD D. MEYER, M.D., F.A.C.P., SYDNEY M. FINEGOLD, M.D., F.A.C.P.Observations of endotoxin-like activity associated with the Legionnaires' disease bacteriumEffect of supplementall-tyrosine on pigment production in cultures of the Legionnaires' disease bacterium 1 March 1978Volume 88, Issue 3Page: 363-365KeywordsEpidemiologyErythromycinInfectious diseasesIschemiaLegionellosisLeukocytosisLungsMedical servicesPneumoniaThorax ePublished: 1 December 2008 Issue Published: 1 March 1978 PDF downloadLoading ...