tbuckley/cabot-search huggingface dataset:
The role of caveolin-1 in the biofate and efficacy of anti-tumor drugs and their nano-drug delivery systems
Authors: Canyu Yang, Bing He, Wenbing Dai, Hua Zhang, Ying Zheng, Xueqing Wang, Qiang Zhang
Journal: Acta Pharmaceutica Sinica B (2020)

As one of the most important components of caveolae, caveolin-1 is involved in caveolae-mediated endocytosis and transcytosis pathways, and also plays a role in regulating the cell membrane cholesterol homeostasis and mediating signal transduction. In recent years, the relationship between the expression level of caveolin-1 in the tumor microenvironment and the prognostic effect of tumor treatment and drug treatment resistance has also been widely explored. In addition, the interplay between caveolin-1 and nano-drugs is bidirectional. Caveolin-1 could determine the intracellular biofate of specific nano-drugs, preventing from lysosomal degradation, and facilitate them penetrate into deeper site of tumors by transcytosis; while some nanocarriers could also affect caveolin-1 levels in tumor cells, thereby changing certain biophysical function of cells. This article reviews the role of caveolin-1 in tumor prognosis, chemotherapeutic drug resistance, antibody drug sensitivity, and nano-drug delivery, providing a reference for the further application of caveolin-1 in nano-drug delivery systems.
Assessment of Left Ventricular, Right Ventricular, and Left Atrial Strain in Light-Chain Amyloidosis
Authors: Douglas J Leedy, Alexi Vasbinder, Hans D Huang, Robin Fernandes, Andrew J Cowan, Ajay K Gopal, James N Kirkpatrick, Edward N Libby, Richard K Cheng
Journal: JACC CardioOncology (2020)
遅延拡張MRI上の信号強度を用いるAMI患者での心筋実現可能性の検査:99m-TcテトロホスミンSPECTとの比較
Authors: Matsushita Nobuya, Kawase Yoshio, Murata Eriko, Doi Atsushi, Hato Katsunori, Nishimoto Masaki, Yoshiyama Minoru
Journal: Circulation (2007)
FGFR Inhibition Overcomes Resistance to EGFR-targeted Therapy in Epithelial-like Cutaneous Carcinoma
Authors: Adrià Bernat-Peguera, Juan Navarro-Ventura, Laura Lorenzo-Sanz, Victoria da Silva-Diz, Mattia Bosio, Luis Palomero, Rosa M. Penin, Diana Pérez Sidelnikova, Josep Oriol Bermejo, Miren Taberna, Noelia Vilariño, Josep M. Piulats, Ricard Mesia, Joan Maria Viñals, Eva González-Suárez, Salvador Capella-Gutierrez, Alberto Villanueva, Francesc Viñals, Purificación Muñoz
Journal: Clinical Cancer Research (2020)

Recurrent and/or metastatic unresectable cutaneous squamous cell carcinomas (cSCCs) are treated with chemotherapy or radiotherapy, but have poor clinical responses. A limited response (up to 45% of cases) to EGFR-targeted therapies was observed in clinical trials with patients with advanced and metastatic cSCC. Here, we analyze the molecular traits underlying the response to EGFR inhibitors, and the mechanisms responsible for cSCC resistance to EGFR-targeted therapy.We generated primary cell cultures and patient cSCC-derived xenografts (cSCC-PDXs) that recapitulate the histopathologic and molecular features of patient tumors. Response to gefitinib treatment was tested and gefitinib-resistant (GefR) cSCC-PDXs were developed. RNA sequence analysis was performed in matched untreated and GefR cSCC-PDXs to determine the mechanisms driving gefitinib resistance.cSCCs conserving epithelial traits exhibited strong activation of EGFR signaling, which promoted tumor cell proliferation, in contrast to mesenchymal-like cSCCs. Gefitinib treatment strongly blocked epithelial-like cSCC-PDX growth in the absence of EGFR and RAS mutations, whereas tumors carrying the E545K PIK3CA-activating mutation were resistant to treatment. A subset of initially responding tumors acquired resistance after long-term treatment, which was induced by the bypass from EGFR to FGFR signaling to allow tumor cell proliferation and survival upon gefitinib treatment. Pharmacologic inhibition of FGFR signaling overcame resistance to EGFR inhibitor, even in PIK3CA-mutated tumors.EGFR-targeted therapy may be appropriate for treating many epithelial-like cSCCs without PIK3CA-activating mutations. Combined EGFR- and FGFR-targeted therapy may be used to treat cSCCs that show intrinsic or acquired resistance to EGFR inhibitors.
Response to: ‘Correspondence on ‘EULAR definition of difficult-to-treat rheumatoid arthritis’’ by Novella-Navarro<i>et al</i>
Authors: Nadia M T Roodenrijs, Paco M J Welsing, Marlies C van der Goes, Johannes WG Jacobs, Désirée van der Heijde, Jacob M van Laar, György Nagy
Journal: Annals of the Rheumatic Diseases (2020)

Correspondence responseIn summary, the EULAR definition of D2T RA, based on international consensus, has been established to unify terminology and the definition.Preferably, this definition will be used in future studies to classify patients with D2T RA uniformly.However, we welcome studies such as that of Novella-Navarro et al to gain further insights into the intricate D2T RA state.Hopefully, all these initiatives, together with the EULAR recommendations for the management of D2T RA that are currently being developed, 12-14 will eventually improve outcomes of patients with D2T RA because that is what it is all about in the end.
The Effect of Physical Cues of Biomaterial Scaffolds on Stem Cell Behavior
Authors: Shuo Wang, Sharareh Hashemi, Scott Stratton, Treena Livingston Arinzeh
Journal: Advanced Healthcare Materials (2020)

Stem cells have been sought as a promising cell source in the tissue engineering field due to their proliferative capacity as well as differentiation potential. Biomaterials have been utilized to facilitate the delivery of stem cells in order to improve their engraftment and long-term viability upon implantation. Biomaterials also have been developed as scaffolds to promote stem cell induced tissue regeneration. This review focuses on the latter where the biomaterial scaffold is designed to provide physical cues to stem cells in order to promote their behavior for tissue formation. Recent work that explores the effect of scaffold physical properties, topography, mechanical properties and electrical properties, is discussed. Although still being elucidated, the biological mechanisms, including cell shape, focal adhesion distribution, and nuclear shape, are presented. This review also discusses emerging areas and challenges in clinical translation.
A bibliometric analysis of periodontology
Authors: Paras Ahmad, Jørgen Slots
Journal: Periodontology 2000 (2020)

Abstract This bibliometric study assessed periodontal/implant articles that were part of the five most‐cited dental articles in each of the years 2005‐2019. Periodontal/implant articles made up one to four articles in each of 14 years and totaled 40% of the yearly five most‐cited dental articles. The three core periodontal journals ( Journal of Clinical Periodontology , Journal of Periodontology , and Periodontology 2000 ) increased ~50%‐100% in Journal Impact Factor from 2005 to 2015 and were among the 10 most‐cited dental journals in the 2015‐2019 period. The Journal of Clinical Periodontology and Periodontology 2000 were in several years assigned the highest Journal Impact Factor in dentistry. In summary, periodontal journals continue to publish high‐impact articles that are relevant for both oral health care and medicine.
Arrhythmias and Dilated Cardiomyopathy: Common Pathogenetic Pathways?⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Authors: Jeffrey A. Towbin, Angela Lorts
Journal: Journal of the American College of Cardiology (2011)
What to Do With Sideline Guilt
Authors: Calvin S. Bruce
Journal: JAMA Internal Medicine (2020)

To the Editor The Physician Perspective by Reuben 1 on sideline guilt should strike a deep chord for many of us.I am a family physician, 72 years old, 6 years retired after an episode of ill health from which I have recovered.So I have my health, food in the refrigerator, enough money in the bank, and a spouse who still puts up with me.The only hardship we face is that coronavirus disease 2019 (COVID-19) has kept us from seeing our far-flung children and grandchildren and forced us to socialize distantly with our friends.Many of my prepandemic activities-working as a nursing home ombudsman, teaching medical students, serving on hospital committees-have been curtailed completely or relegated to virtual visits.That I, as a noncritical care specialist, could meaningfully replace a frontline worker is a dubious proposition at best.As Reuben 1 points out, staying away from hospitals may be the most constructive thing some of us can do.But beyond the world of medicine, there is so much more to feel guilty about.The COVID-19 pandemic and current events have brought into sharp focus the long-standing racial and class inequities from which I and so many who might read this have undoubtedly benefited in one way or another.I would add 2 suggestions to those Reuben 1 has proposed.First, allow yourself to experience gratitude if you float in the same guilty boat as I do: gratitude that you have the boat.Second, get angry about the state of the world and get motivated.The Viewpoint by Berwick 2 on the moral determinants of health is a good place to start.There is much that those of us who are blessed not to be suffering in these difficult times can do to help make sure the new normal will better than the old.
Prognostic Genomic Biomarkers in Patients With Localized Prostate Cancer
Authors: Daniel W. Lin, Peter S. Nelson
Journal: JAMA Oncology (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Early Adaptation of Colorectal Cancer Cells to the Peritoneal Cavity Is Associated with Activation of “Stemness” Programs and Local Inflammation
Authors: Jorge Barriuso, Raghavendar T. Nagaraju, Shreya Belgamwar, Bipasha Chakrabarty, George J. Burghel, Helene Schlecht, Lucy Foster, Elaine Kilgour, Andrew J. Wallace, Michael Braun, Caroline Dive, D. Gareth Evans, Robert G. Bristow, Mark P. Saunders, Sarah T. O'Dwyer, Omer Aziz
Journal: Clinical Cancer Research (2020)

At diagnosis, colorectal cancer presents with synchronous peritoneal metastasis in up to 10% of patients. The peritoneum is poorly characterized with respect to its superspecialized microenvironment. Our aim was to describe the differences between peritoneal metastases and their matched primary tumors excised simultaneously at the time of surgery. Also, we tested the hypothesis of these differences being present in primary colorectal tumors and having prognostic capacity.
326P Management of diffuse large B cell lymphomas in the COVID-19 era
Authors: D.Z. Ng, H.X. Kang, S.H. Tan, V. Shih, Q. Zhuang, J. Chiang, E.W.Y. Chang, J. Chan, E.Y.L. Poon, N. Somasundaram, K.W. Yeoh, M. Farid, T.P.L. Tang, M. Tao, S.T. Lim, V.S. Yang
Journal: Annals of Oncology (2020)
Spatial profiling of gastric cancer patient-matched primary and locoregional metastases reveals principles of tumour dissemination
Authors: Raghav Sundar, Drolaiz HW Liu, Gordon GA Hutchins, Hayley L Slaney, Arnaldo NS Silva, Jan Oosting, Jeremy D Hayden, Lindsay C Hewitt, Cedric CY Ng, Amrita Mangalvedhekar, Sarah B Ng, Iain BH Tan, Patrick Tan, Heike I Grabsch
Journal: Gut (2020)

Endoscopic mucosal biopsies of primary gastric cancers (GCs) are used to guide diagnosis, biomarker testing and treatment. Spatial intratumoural heterogeneity (ITH) may influence biopsy-derived information. We aimed to study ITH of primary GCs and matched lymph node metastasis (LNmet).GC resection samples were annotated to identify primary tumour superficial (PTsup), primary tumour deep (PTdeep) and LNmet subregions. For each subregion, we determined (1) transcriptomic profiles (NanoString 'PanCancer Progression Panel', 770 genes); (2) next-generation sequencing (NGS, 225 gastrointestinal cancer-related genes); (3) DNA copy number profiles by multiplex ligation-dependent probe amplification (MLPA, 16 genes); and (4) histomorphological phenotypes.NanoString profiling of 64 GCs revealed no differences between PTsup1 and PTsup2, while 43% of genes were differentially expressed between PTsup versus PTdeep and 38% in PTsup versus LNmet. Only 16% of genes were differently expressed between PTdeep and LNmet. Several genes with therapeutic potential (eg IGF1, PIK3CD and TGFB1) were overexpressed in LNmet and PTdeep compared with PTsup. NGS data revealed orthogonal support of NanoString results with 40% mutations present in PTdeep and/or LNmet, but not in PTsup. Conversely, only 6% of mutations were present in PTsup and were absent in PTdeep and LNmet. MLPA demonstrated significant ITH between subregions and progressive genomic changes from PTsup to PTdeep/LNmet.In GC, regional lymph node metastases are likely to originate from deeper subregions of the primary tumour. Future clinical trials of novel targeted therapies must consider assessment of deeper subregions of the primary tumour and/or metastases as several therapeutically relevant genes are only mutated, overexpressed or amplified in these regions.
Anti–tumor necrosis factor therapy is associated with increased in situ squamous cell carcinoma of the skin: A population-based case-control study
Authors: Jonas A. Adalsteinsson, Sonal Muzumdar, Reid Waldman, Chaoran Hu, Rong Wu, Désirée Ratner, Jonathan Ungar, Jonathan I. Silverberg, Gudridur H. Olafsdottir, Arni Kjalar Kristjansson, Laufey Tryggvadottir, Jon Gunnlaugur Jonasson
Journal: Journal of the American Academy of Dermatology (2020)
13767 Responder characteristics in patients with molluscum contagiosum (MC) treated with VP-102 achieving complete clearance: Pooled results of two phase 3 multicenter, randomized, vehicle-controlled trials for the topical treatment of MC
Authors: Lawrence F. Eichenfield, Steven R. Cohen, Janice L. Pelletier, Pieter d’Arnaud, Melissa Olivadoti, Patrick Burnett
Journal: Journal of the American Academy of Dermatology (2020)
Author Correction: The cellular composition of the human immune system is shaped by age and cohabitation
Authors: Edward J. Carr, James Dooley, Josselyn E. Garcia-Perez, Vasiliki Lagou, James C. Lee, Carine Wouters, Isabelle Meyts, An Goris, Guy Boeckxstaens, Michelle A. Linterman, Adrian Liston
Journal: Nature Immunology (2020)
18063 Geographic distribution, climate, and soil type of mycetoma cases in northeast Mexico
Authors: Jesus Alberto Cardenas–de la Garza, Adrian Cuellar-Barboza, Oliverio Welsh, Karina Paola Suarez Sanchez, Luis Gerardo Cruz-Gomez, Estephania de la Cruz-Valadez, Lucio Vera-Cabrera
Journal: Journal of the American Academy of Dermatology (2020)
Distinction between peanut allergy and tolerance by characterization of B cell receptor repertoires
Authors: Anna M. Ehlers, Constance F. den Hartog Jager, André C. Knulst, Henny G. Otten
Journal: Allergy (2021)

Specific IgE against a peanut 2S albumin (Ara h 2 or 6) is the best predictor of clinically relevant peanut sensitization. However, sIgE levels of peanut allergic and those of peanut sensitized but tolerant patients partly overlap, highlighting the need for improved diagnostics to prevent incorrect diagnosis and consequently unnecessary food restrictions. Thus, we sought to explore differences in V(D)J gene transcripts coding for peanut 2S albumin-specific monoclonal antibodies (mAbs) from allergic and sensitized but tolerant donors.2S albumin-binding B-cells were single-cell sorted from peripheral blood of peanut allergic (n=6) and tolerant (n=6) donors sensitized to Ara h2 and/or 6 (≥ 0.1 kU/l) and non-atopic controls (n=5). h 2 and/or 6 (≥ 0.1 kU/l). Corresponding h heavy and light chain gene transcripts were heterologously expressed as mAbs and tested for specificity to native Ara h2 and 6. HCDR3 sequence motifs were identified by Levenshtein distances and hierarchically clustering.The frequency of 2S albumin-binding B cells was increased in allergic (median: 0.01%) compared to tolerant (median: 0.006%) and non-atopic donors (median: 0.0015%, p = 0.008). The majority of mAbs (74%, 29/39) bound specifically to Ara h 2 and/or 6. Non-specific mAbs (9/10) were mainly derived from non-atopic controls. In allergic donors, 89% of heavy chain gene transcripts consisted of VH3 family genes, compared with only 54% in sensitized but tolerant and 63% of non-atopic donors. Additionally, certain HCDR3 sequence motifs were associated with allergy (n = 4) or tolerance (n = 3) upon hierarchical clustering of their Levenshtein distances.Peanut allergy is associated with dominant VH3 family gene usage and certain public antibody sequences (HCDR3 motifs).
Endovascular Treatment for Erectile Dysfunction: An Old Paradigm Revisited⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Authors: Mehdi H. Shishehbor, Femi Philip
Journal: Journal of the American College of Cardiology (2012)
18715 A retrospective cohort: Genomic differences between pigmented spindle cell nevus of reed and reed-like melanomas
Authors: Daniel Kim, Ayesha U. Khan, Elsy V. Compres, Katherine Shi, Katherine Shi - Bin Zhang, Victor L. Quan, Elnaz Panah, Pedram Yazdan, Pedram Gerami
Journal: Journal of the American Academy of Dermatology (2020)
Repolarization Recipes for Atrial Fibrillation: Beyond Single Channel Variants⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Authors: Dawood Darbar, Babar Parvez, Robert Abraham
Journal: Journal of the American College of Cardiology (2012)
Microbiomics: Were we all wrong before?
Authors: Purnima S. Kumar
Journal: Periodontology 2000 (2020)

Abstract Periodontal microbiology has historically been based on an “us against them” paradigm, one that focuses mainly on identifying microbes and viruses that cause disease. However, such a bottom‐up approach limits our appreciation of the incredible diversity of this ecosystem and the essential ways in which microbial interactions contribute to health and homeostasis of the subgingival niche. Microbiomics—the science of collectively characterizing and quantifying molecules responsible for the structure, function, and dynamics of a microbial community—has enabled us to study these communities in their natural habitat, thereby revolutionizing our knowledge of host‐associated microbes and reconceptualizing our definition of “human.” When this systems‐biology approach is combined with ecologic principles, it explicates the complex relationship that exist between microbiota and between them and us, the human. In this volume of Periodontology 2000 , a group of 12 female scientists take the lead in investigating how metagenomics, genomics, metatranscriptomics, proteomics, metaproteomics, and metabolomics have achieved the following: (a) widened our view of the periodontal microbiome; (b) expanded our understanding of the evolution of the human oral microbiome; (c) shone a light on not just bacteria, but also other prokaryotic and eukaryotic members of the community; (d) elucidated the effects of anthropogenic behavior and systemic diseases on shaping these communities; and (e) influenced traditional patterns of periodontal therapeutics.
345P Thromboembolic events in brain tumour patients on bevacizumab
Authors: G.K. Singh, N. Menon, M.M. Jadhav, R. Walavalkar, H. Dsouza, S. Roy, S. Das, S. Sujay Srinivas, D.H. Vallathol, V.M. Patil
Journal: Annals of Oncology (2020)
Monocyte and bone marrow macrophage transcriptional phenotypes in systemic juvenile idiopathic arthritis reveal TRIM8 as a mediator of IFN-γ hyper-responsiveness and risk for macrophage activation syndrome
Authors: Grant S Schulert, Alex V Pickering, Thuy Do, Sanjeev Dhakal, Ndate Fall, Daniel Schnell, Mario Medvedovic, Nathan Salomonis, Sherry Thornton, Alexei A Grom
Journal: Annals of the Rheumatic Diseases (2020)

Systemic juvenile idiopathic arthritis (SJIA) confers high risk for macrophage activation syndrome (MAS), a life-threatening cytokine storm driven by interferon (IFN)-γ. SJIA monocytes display IFN-γ hyper-responsiveness, but the molecular basis of this remains unclear. The objective of this study is to identify circulating monocyte and bone marrow macrophage (BMM) polarisation phenotypes in SJIA including molecular features contributing to IFN response.Bulk RNA-seq was performed on peripheral blood monocytes (n=26 SJIA patients) and single cell (sc) RNA-seq was performed on BMM (n=1). Cultured macrophages were used to define consequences of tripartite motif containing 8 (TRIM8) knockdown on IFN-γ signalling.Bulk RNA-seq of SJIA monocytes revealed marked transcriptional changes in patients with elevated ferritin levels. We identified substantial overlap with multiple polarisation states but little evidence of IFN-induced signature. Interestingly, among the most highly upregulated genes was TRIM8, a positive regulator of IFN-γ signalling. In contrast to PBMC from SJIA patients without MAS, scRNA-seq of BMM from a patient with SJIA and MAS identified distinct subpopulations of BMM with altered transcriptomes, including upregulated IFN-γ response pathways. These BMM also showed significantly increased expression of TRIM8. In vitro knockdown of TRIM8 in macrophages significantly reduced IFN-γ responsiveness.Macrophages with an 'IFN-γ response' phenotype and TRIM8 overexpression were expanded in the bone marrow from an MAS patient. TRIM8 is also upregulated in SJIA monocytes, and augments macrophage IFN-γ response in vitro, providing both a candidate molecular mechanism and potential therapeutic target for monocyte hyper-responsiveness to IFNγ in cytokine storms including MAS.