tbuckley/cabot-search huggingface dataset:
Innervation of Sweat Glands in Horses and Dogs
Authors: D. W. K. Cotton, P. Hasselt
Journal: British Journal of Dermatology (1972)

Journal Article Innervation of Sweat Glands in Horses and Dogs Get access D. W. K. Cotton, D. W. K. Cotton Department of Dermatology and Department of General Neurophysiology University of Nijmegen Nijmegen Holland Search for other works by this author on: Oxford Academic Google Scholar P. Van Hasselt P. Van Hasselt Department of Dermatology and Department of General Neurophysiology University of Nijmegen Nijmegen Holland Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 87, Issue 1, 1 July 1972, Pages 80–81, https://doi.org/10.1111/j.1365-2133.1972.tb05106.x Published: 01 July 1972
Treatment of Duchenne's Muscular Dystrophy
Authors: Thomas S. Renshaw
Journal: JAMA (1982)

To the Editor.—  The recent article by Crisp and colleagues (1982;247:478) and the accompanying editorial by Shelborne (1982;247:496), both of which emphasize the value of early diagnosis in Duchenne's muscular dystrophy (DMD), are highly commendable and may help to prevent needless tragedy and suffering. However, not everyone will agree with the authors' statements that the disease is untreatable; that there is no effective therapy; that there is no treatment; and that we have little more to offer in this tragic disorder.  The disease may be incurable, but it is not untreatable. The natural history of untreated DMD is that most children will stop walking by age 9 to 12 years, and, once confined to a wheelchair, the development of flexion contractures of major joints and progressive equinovarus foot deformities is rapid. At the same time, progressive scoliosis develops in about 60% of patients with DMD, which may eventually terminate their
The microcirculation of the human heart: end-capillary loops with discrete perfusion fields.
Authors: S MFactor, E MOkun, TMinase, E SKirk
Journal: Circulation (1982)

We studied 10 autopsied human hearts by perfusing colored Microfil into separate coronary arteries to define organization of capillaries at the borders between two perfusion fields. Sections of cleared myocardium were examined with epiillumination at the grossly identified borders of Microfil perfusion. In two- and three-color-injected hearts, the capillaries were arrayed in a pattern of arcades and loops without connections between separately perfused capillary beds. In hearts perfused through only one coronary artery, the capillaries were organized into tufted loops at the border. These findings contrast with the microcirculatory pattern in canine skeletal muscle and brain, in which heterologous capillaries are focally interconnected. We conclude that the human microcirculation is composed of end-capillary loops that supply discrete perfusion fields. This pattern of unconnected heterologous capillary beds suggest that there is no obvious anatomic arrangement of the microcirculation that could account ...
Vasoactive intestinal polypeptide facilitates atrioventricular nodal conduction and shortens atrial and ventricular refractory periods in conscious and anesthetized dogs.
Authors: D FRigel, D ALathrop
Journal: Circulation Research (1990)

Our study was designed to determine the cardiac electrophysiological influence of vasoactive intestinal polypeptide (VIP) in conscious dogs. Dogs (n = 8) were chronically instrumented with arterial and venous catheters, cervical vagal cooling coils, and right atrial and right ventricular bipolar epicardial pacing and recording electrodes. After autonomic blockade (10 mg/kg i.v. hexamethonium, 0.11 mg/kg i.v. atropine, and vagal cold blockade), VIP (50 and 100 pmol/kg/min i.v.) or isoproterenol (ISO) (250 and 500 pmol/kg/min i.v.) increased heart rate (maximum increases: VIP, 81.1 +/- 4.2 beats/min; ISO, 61.3 +/- 8.5 beats/min), decreased the atrial-ventricular interval (during constant atrial pacing) (VIP, -41.9 +/- 6.3 msec; ISO, -34.6 +/- 7.4 msec), shortened the atrial effective refractory period (VIP, -24.4 +/- 2.1 msec; ISO, -30.6 +/- 4.4 msec) and ventricular effective refractory period (VIP, -4.2 +/- 0.7 msec; ISO, -10.0 +/- 2.4 msec), and decreased mean arterial pressure (VIP, -51.9 +/- 4.0 mm Hg;...
Hemodynamics of arterial stenoses at elevated flow rates.
Authors: D FYoung, N RCholvin, R LKirkeeide, A CRoth
Journal: Circulation Research (1977)

This study is concerned with the pressure drop that develops across an arterial stenosis, with particular emphasis on the effect of the stenosis at high blood flow rates induced by a locally administered vasodilator drug. Stenoses, ranging in severity from 55.7% to 91.0% reduction in lumen area were artificially induced in the femoral and carotid arteries of large mongrel dogs. Instantaneous flow rates and pressure drops were measured over a wide range of flow conditions. Mean velocities varied from 3.9 to 88.8 cm/sec. Experimental data support the applicability of a relatively simple equation for predicting the pressure drop over this wide range of velocities and stenosis geometries. Results show that blood flow through a particular artery can increase by a large factor, in the range of 4-5, under conditions of vasodilation with a corresponding large decrease in pressure distal to the stenosis. The pressure drop increases in a nonlinear manner with velocity and thereby accentuates the importance of the s...
It Is Too Early to Declare Early or Late Rescue High-Frequency Oscillatory Ventilation Dead
Authors: Sandrine Essouri, Guilllaume Emeriaud, Philippe Jouvet
Journal: JAMA Pediatrics (2014)

To the Editor We read with interest the study by Gupta et al1in the recent issue of JAMA Pediatrics. The value of high-frequency oscillatory ventilation (HFOV) in the management of severe acute respiratory failure is a recurrent question for pediatric intensivists.
Reprogramming lipid metabolism prevents effector T cell senescence and enhances tumor immunotherapy
Authors: Xia Liu, Celine L. Hartman, Lingyun Li, Carolyn J. Albert, Fusheng Si, Aiqin Gao, Lan Huang, Yangjing Zhao, Wenli Lin, Eddy C. Hsueh, Lizong Shen, Qixiang Shao, Daniel F. Hoft, David A. Ford, Guangyong Peng
Journal: Science Translational Medicine (2021)

The functional state of T cells is a key determinant for effective antitumor immunity and immunotherapy. Cellular metabolism, including lipid metabolism, controls T cell differentiation, survival, and effector functions. Here, we report that development of T cell senescence driven by both malignant tumor cells and regulatory T cells is a general feature in cancers. Senescent T cells have active glucose metabolism but exhibit unbalanced lipid metabolism. This unbalanced lipid metabolism results in changes of expression of lipid metabolic enzymes, which, in turn, alters lipid species and accumulation of lipid droplets in T cells. Tumor cells and T
TCTAP C-060 Coronary Perforation Sealed with Fat Embolization
Authors: Faten Aqilah Binti Aris, Wan Faizal Bin Wan Rahimi Shah, Faizal Khan Abdullah, Afif Ashari, Jayakhanthan Kolanthaivelu, Shaiful Azmi Yahaya, Kumara Gurupparan Ganesan
Journal: Journal of the American College of Cardiology (2021)
Loss of ARID1A activates mTOR signaling and SOX9 in gastric adenocarcinoma—rationale for targeting <i>ARID1A</i> deficiency
Authors: Xiaochuan Dong, Shumei Song, Yuan Li, Yibo Fan, Lulu Wang, Ruiping Wang, Longfei Huo, Ailing Scott, Yan Xu, Melissa Pool Pizzi, Lang Ma, Ying Wang, Jiangkang Jin, Wei Zhao, Xiaodan Yao, Randy L Johnson, Linghua Wang, Zhenning Wang, Guang Peng, Jaffer A Ajani
Journal: Gut (2021)

Gastric adenocarcinoma (GAC) is a lethal disease with limited therapeutic options. Genetic alterations in chromatin remodelling gene AT-rich interactive domain 1A (ARID1A) and mTOR pathway activation occur frequently in GAC. Targeting the mechanistic target of rapamycin (mTOR) pathway in unselected patients has failed to show survival benefit. A deeper understanding of GAC might identify a subset that can benefit from mTOR inhibition.Genomic alterations in ARID1A were analysed in GAC. Mouse gastric epithelial cells from CK19-Cre-Arid1Afl/fl and wild-type mice were used to determine the activation of oncogenic genes due to loss of Arid1A. Functional studies were performed to determine the significance of loss of ARID1A and the sensitivity of ARID1A-deficient cancer cells to mTOR inhibition in GAC.More than 30% of GAC cases had alterations (mutations or deletions) of ARID1A and ARID1A expression was negatively associated with phosphorylation of S6 and SOX9 in GAC tissues and patient-derived xenografts (PDXs). Activation of mTOR signalling (increased pS6) and SOX9 nuclear expression were strongly increased in Arid1A-/- mouse gastric tissues which could be curtailed by RAD001, an mTOR inhibitor. Knockdown of ARID1A in GAC cell lines increased pS6 and nuclear SOX9 and increased sensitivity to an mTOR inhibitor which was further amplified by its combination with fluorouracil both in vitro and in vivo in PDXs.The loss of ARID1A activates pS6 and SOX9 in GAC, which can be effectively targeted by an mTOR inhibitor. Therefore, our studies suggest a new therapeutic strategy of clinically targeting the mTOR pathway in patients with GAC with ARID1A deficiency.
Intrahepatic bile duct stone Treatment with a Cholangioscopic-Assisted Basket
Authors: M Bassi, P Apolito, S Landi, S Ghersi, E Dabizzi, V Cennamo
Journal: Endoscopy (2021)

We report a case of a 68-year-old man, admitted to our Unit for jaundice and difficult common bile duct stones.
A renin inhibitor from rabbit kidney: conversion of a large inactive renin to a smaller active enzyme.
Authors: B JLeckie, AMcConnell
Journal: Circulation Research (1975)

Renin in extracts of frozen rabbit kidney exists in two forms: active (molecular weight about 37,000) and inactive (molecular weight about 55,000) renin. The inactive form becomes active after exposure to pH 2.5 at 4 degrees C. If extracts are chromatographed on DEAE cellulose, the inactive renin dissociates into active renin plus a renin inhibitor (molecular weight about 13,000). The inhibitor recombines with active renin if the two are incubated together at 37 degrees C. The inhibitor is destroyed by acid treatment at pH 2.5 at 4 degrees C. We conclude that the activation of inactive renin is due to destruction of the inhibitor by acid. The inactive material may be a renin proenzyme or a storage form of active renin combined with inhibitor.
Nanogels: A novel approach in antimicrobial delivery systems and antimicrobial coatings
Authors: Damla Keskin, Guangyue Zu, Abigail M. Forson, Lisa Tromp, Jelmer Sjollema, Patrick van Rijn
Journal: Bioactive Materials (2021)

The implementation of nanotechnology to develop efficient antimicrobial systems has a significant impact on the prospects of the biomedical field. Nanogels are soft polymeric particles with an internally cross-linked structure, which behave as hydrogels and can be reversibly hydrated/dehydrated (swollen/shrunken) by the dispersing solvent and external stimuli. Their excellent properties, such as biocompatibility, colloidal stability, high water content, desirable mechanical properties, tunable chemical functionalities, and interior gel-like network for the incorporation of biomolecules, make them fascinating in the field of biological/biomedical applications. In this review, various approaches will be discussed and compared to the newly developed nanogel technology in terms of efficiency and applicability for determining their potential role in combating infections in the biomedical area including implant-associated infections.
Effect of thromboxane A2/endoperoxide antagonist SQ29548 on the contractile response to acetylcholine in newborn piglet cerebral arteries.
Authors: L CWagerle, D WBusija
Journal: Circulation Research (1990)

Previous studies have shown that cholinergic stimulation results in a prostanoid-dependent cerebral vasoconstriction in piglets. The present study specifically investigated the contribution of thromboxane A2 (TXA2)/prostaglandin endoperoxide and prostaglandin F2 alpha (PGF2 alpha) to the cerebral vascular response to exogenous acetylcholine (ACh). Effects of TXA2/prostaglandin endoperoxide-receptor antagonist SQ29548 on responsiveness of pial arterioles to ACh (10(-7) and 10(-4) M), PGF2 alpha (10(-7)-10(-5) M), TXA2 mimetic 9,11-methanoepoxy prostaglandin H2 (U46619, 5 and 10 ng/ml), and norepinephrine (10(-6)-10(-4) M) were studied by use of a closed cranial window in 37 anesthetized mechanically ventilated newborn piglets. Pial arteriolar diameter was measured by intravital microscopy. Topical application of exogenous PGF2 alpha and U46619 resulted in dose-dependent cerebral vasoconstriction, and the dose-response curve for each agonist was shifted to the right by the increasing concentrations of SQ295...
Resident Forum
Authors: Mark S. Litwin
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cigarette Smoking and Risk of Myeloma
Authors: MILLS PAUL K.
Journal: JNCI Journal of the National Cancer Institute (1991)

Cigarette Smoking and Risk of Myeloma Get access MILLS PAUL K. MILLS PAUL K. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 14, 17 July 1991, Page 1037, https://doi.org/10.1093/jnci/83.14.1037 Published: 17 July 1991
Acute hypertension after the local injection of kainic acid into the nucleus tractus solitarii of rats.
Authors: W TTalman, M HPerrone, D JReis
Journal: Circulation Research (1981)

Kainic acid (KA), an analogue of L-glutamate, was microinjected in 0.1 microliter of saline into the nucleus tractus solitarii (NTS) of adult rats. In rats anesthetized with halothane or alpha-chloralose, KA injected unilaterally elicited hypotension, bradycardia, and apnea. The threshold dose was 0.1-0.2 ng (10(-13) mol). Doses greater than 0.2 ng blocked responses to subsequent injections for at least 30 minutes. Doses of KA greater than 15 ng reduced the reflex bradycardia elicited by raising the arterial pressure with phenylephrine and produced arterial hypertension in rats anesthetized with alpha-chloralose or in other rats within 15 minutes of terminating halothane anesthesia. Bilateral injection of KA in doses greater than 15 ng completely blocked baroreflexes and resulted in a dose-dependent elevation of arterial pressure (167 +/- 9.4; P less than 0.001) both in alpha-chloralose-anesthetized rats and in awake rats after the termination of halothane anesthesia. The hypertension rapidly led to pulmo...
Employment status after coronary artery bypass surgery.
Authors: AOberman, J BWayne, N TKouchoukos, E DCharles, R ORussell, W JRogers
Journal: Circulation (1982)

With a few exceptions, prevailing data on return to work after coronary artery bypass surgery indicate no net gain in employment status for at least several years after the operation. Despite the improved surgical experience and advances in the medical management of postoperative patients, only limited employment benefits occur after surgery, and no gains in work rehabilitation over the past decade have been noted. Several characteristics--preoperative work status, nonwork income, occupation, relief of symptoms, age, perception of health, education and severity of disease--appear to be important for estimating the likelihood of employment after surgery. Other influences, such as attitudes of the family, employers and physicians, undoubtedly alter the probability of return to the work force, but are less well documented. Unless constructive approaches toward work rehabilitation are made, the possibility of return to gainful employment should not be considered an indication for or a necessary consequence of...
Echocardiographic measurements in normal subjects. Growth-related changes that occur between infancy and early adulthood.
Authors: W LHenry, JWare, J MGardin, S IHepner, JMcKay, MWeiner
Journal: Circulation (1978)

Echocardiographic measurements of the left ventricular dimensions and wall thicknesses at end diastole and end systole, aortic root and left atrial dimensions, mitral valve E-F slope, left ventricular ejection fraction, percent fractional shortening of the left ventricular internal dimension, estimated left ventricular mass and percentage systolic thickening of the ventricular septum and left ventricular free wall were obtained in 105 normal subjects ranging from one day to 23 years of age. Each parameter was found to follow a linear regression upon one of three functions of the body surface area. The internal dimensions of left ventricle, the left atrium, and the aortic root, and the mitral valve E-F slope varied in a linear relation to the cube root of the body surface area. Thickness of the ventricular septum and left ventricular free wall varied in a linear relation to the square root of the body surface area. Estimated left ventricular mass varied linearly with the direct measurement of body surface ...
The importance of defining left ventricular area at risk in vivo during acute myocardial infarction: an experimental evaluation with myocardial contrast two-dimensional echocardiography.
Authors: SKaul, WGlasheen, T DRuddy, N GPandian, A EWeyman, R DOkada
Journal: Circulation (1987)

Because the left ventricular  at  is the most important determinant of ultimate infarct size, it would be useful to know the size of the area at risk during acute myocardial infarction to make therapeutic decisions. We therefore performed a series of experiments in four groups of dogs. In group I dogs (n = 15) we attempted to determine whether current methods of assessing left ventricular function during acute myocardial infarction reflect the true size of the area at risk. At each of two to five sequential stages, a more proximal coronary occlusion was performed to produce a larger area at risk until cardiovascular collapse occurred. At each stage, the area at risk (measured by myocardial contrast echocardiography), hemodynamic variables, and left ventricular ejection fraction (LVEF) were measured. Hemodynamic variables became abnormal when the area at risk was large (25% to 40% of the left ventricle), whereas LVEF became abnormal when the area at risk was of moderate size (18%). When cardiac o...
The effects of reperfusion and retrograde coronary flow bleeding after coronary occlusion on induced electrical instability in the dog.
Authors: B AJones-Collins, R EPatterson
Journal: Circulation (1983)

Reperfusion achieved by streptokinase infusion early after myocardial infarction (MI) is now being performed in patients, but the effect on electrical instability of increasing or decreasing perfusion in the region at risk for MI is unknown. Accordingly, 34 dogs were randomized to control (13 dogs), reperfusion (11 dogs) and retrograde bleeding (10 dogs) groups. All dogs underwent coronary artery occlusion (23 of the left anterior descending and 11 of the circumflex artery). In the control dogs, occlusion was permanent. In the reperfused dogs, the occlusion was released at 2 hours. In the retrograde bleeding dogs, retrograde flow bleeding distal to the occlusive tie was continued for 2 hours after coronary occlusion. Four days later, all dogs underwent a standard right ventricular pacing protocol. Induced arrhythmias were scored; ventricular fibrillation was assigned the highest score, followed by sustained ventricular tachycardia, nonsustained ventricular tachycardia and repetitive ventricular response. ...
Coeliac: A Gut Feeling. An Investigation Into What Factors Influence Patterns Of Clinical Presentation In Adult Onset Coeliac Disease
Authors: K O’Shaughnessy, L Jackson, W Stack, T Hayes, E Kenny
Journal: Endoscopy (2021)

Aims Anxiety and depression are common in coeliac disease (CD) patients, and many psycho-social explanations have been considered. However, as the gut-brain axis is becoming increasingly understood, biological mechanisms have been proposed, including vitamin or mineral deficiencies and gut inflammation. The aim of this study was to investigate associations between anxiety/depression and symptom severity, vitamin status, and gut inflammation in untreated adult patients presenting with a serologic indication of coeliac disease.
Toxic Alcohol Calculations and Misinterpretation of Laboratory Results
Authors: Peter E. Wu, Marco L. A. Sivilotti
Journal: JAMA Internal Medicine (2016)

To the Editor We read with interest the Teachable Moment in a recent issue of JAMA Internal Medicine by Himmel and colleagues1 and commend them on sharing this experience of medical error and disclosure. Regarding the clinical aspects of toxic alcohol poisoning, a few points merit discussion.
Development and Evaluation of an Interventional Training Model for Flexible Endoscopy In Roux-En-Y Anatomy
Authors: K Koch, U Schweizer, B Mothes, D Wichmann, KE Grund
Journal: Endoscopy (2021)

Aims Surgery in the upper gastrointestinal tract can result in significantly altered anatomy. A common variation of the resulting anatomy is the Roux-Y reconstruction. Altered anatomy leads to an increasing risk for technically failures during follow-up endoscopies. Especially interventions for choledocholithiasis after bariatric surgery are complex. A realistic and patient-analogue training model is not yet available, but could improve the quality of diagnostic and therapeutic endoscopy in patients with surgically altered anatomy.
Correlation of function and morphology of neonatal rat and embryonic chick cultured cardiac and vascular muscle cells.
Authors: W JMarvin, R BRobinson, KHermsmeyer
Journal: Circulation Research (1979)

To develop morphological criteria which can be applied systematically for the identification of isolated cardiac and vascular muscle cells in mammalian and avian primary cultures, we have correlated structural and staining properties with excitability, contraction, and norepinephrine sensitivity of isolated muscle cells. The primary cultures of cardiac and vascular muscle contained muscle cells and nonmuscle cells. The muscle cells could be clearly identified by action potentials, contractility, and Masson's trichrome stain characteristics, similar to those of cells from intact source heart and blood vessels. Furthermore, the muscle cells were highly responsive to norepinephrine, showing unequivocal increases in contraction frequency. The sensitivity to norepinephrine was found to be very high (ED50 = 2.3 X 10(-9) M) Phase-contrast observation was sufficient to identify muscle cells only when those cells were contracting. There were no unequivocal morphological characteristics that distinguished between q...
141P Chemotherapy with or without immunotherapy or bevacizumab for EGFR-mutated lung cancer after progression on osimertinib
Authors: M. White, J.W. Neal, R.M. Gardner, K.M. Cunanan, M. Das, S.K. Padda, K. Ramchandran, T.T. Chen, H. Wakelee
Journal: Journal of Thoracic Oncology (2021)