tbuckley/cabot-search huggingface dataset:
Isolated chemotherapeutic perfusion as neoadjuvant therapy for advanced/unresectable pelvic malignancy
Authors: H. J. Wanebo, G. Begossi, J. Belliveau, E. Gustafson
Journal: Journal of Clinical Oncology (2009)

2555 Background: Isolated pelvic perfusion (IPP) provides higher tissue drug levels than high-dose systemic therapy and may enhance resectability and survival in patients failing chemo radiation ± surgery. We performed 113 IPP in 68 patients (34 palliative, and 44 pre op) using a simplified balloon occlusion technique. Methods: 42 patients had advanced (irradiated) rectal cancer, 8 pts had advanced anorectal cancer, 5 patients had sarcoma. Other cancers included melanoma (M 4pts), endometrial cancer (EC) 2, ovarian cancer (OC) 2, and bladder cancer (BC) 1. Chemotherapy agents included 5FU, (1,500–2,000mg/M 2 ), cisplatinum (100mg/M 2 ), Oxaliplatin and mitomycin (10–20mg/M 2 ) for epithelial cancer and selected agents (Adriamycin, Ifosamide, DTIC, Phenyl Alanine Mustard (PAM) for the remaining tumors: 6 pts received high dose PAM (110/M 2 ), Paclitaxel 60mg/m 2 and Cisplatin 150mg/m 2 , 3 required stem cell support (advanced M (1 pt), SCC (1 pt), Endometrial ca (1pt). Results: Palliative IPP for advanced rectal cancer pts provided significant pain control (1–4 months) in 11 of 14 pts with narcotic resistant pain and induced tumor regression in 6 pts. Preoperative perfusion in 26 advanced rectal cancer pts induced a complete path response (in pelvis) in 2 pts and significant regression in 11 pts rendering them resectable. 7 had RO resection with clear margins: of the other pts 1 had a path CR negating resection, 3 refused pelvic resection, 2 became inoperable. Median survival post IPP was 24 mos in 12 patients considered resectable vs. 8 mos in 12 patients considered non resectable p&lt;0.05. It was 30 months in 8 pts with advanced anorectal squamous cancer (1pt survived &gt;90 mos), 20 months in 4 patients with endometrial/ovarian recurrence, (1 died NED &gt;48 mos), 13 mos in 4 melanoma pts and only 5 months in 5 pts pelvic sarcoma (4–34 mos-NED). Overall 17 of 44 pts (39%) were resected and 24 had significant palliative benefit. Conclusions: IPP with high dose chemo therapy has promise in palliating or augmenting resectability of advanced pelvic malignancy persisting after conventional surgical and chemoradiation therapy. Stem cell support and biologic therapy merit further exploration. No significant financial relationships to disclose.
Prospective Comparison of Angiogenesis-Specific 68Ga-RGD2 PET/CT Imaging Parameters and DAS28-ESR in Rheumatoid Arthritis
Authors: Anwin Joseph Kavanal, Anish Bhattacharya, Aman Sharma, Jaya Shukla, Arghya Chattopadhyay, Adarsh M B, Vikas Sharma, Rakhee Vatsa, Nivedita Rana, Gurvinder Kaur, Bhagwant Rai Mittal
Journal: Clinical Nuclear Medicine (2021)

Objective The aim of this study was to compare the performance of angiogenesis-specific 68 Ga-RGD 2 PET/CT with Disease Activity Score 28–erythrocyte sedimentation rate (DAS28-ESR) in assessing disease activity and treatment response in rheumatoid arthritis (RA). Methods This was a prospective study comparing the performance of 68 Ga-RGD 2 PET/CT and DAS28-ESR in 30 RA patients. All of them underwent 68 Ga-RGD 2 PET/CT scan from head to toe and clinical examination at the baseline. A repeat scan and clinical examination were done in 27 patients after 3 months of treatment with disease-modifying antirheumatic drugs ± steroids. Three PET parameters, that is, PJC (PET-positive joint count), aSUV max (average SUV max ), and hSUV max (highest SUV max ), of positive joints were compared with the DAS28-ESR for disease activity assessment and response evaluation. Results Among the 3 PET parameters, PJC showed a significant correlation with the DAS28-ESR (0.64, P &lt; 0.01). A significant change was observed with treatment in the DAS28-ESR and PET parameters of 27 patients at follow-up. There was significant correlation between percentage changes in DAS28-ESR and scan parameters such as PJC (0.689, P &lt; 0.001), aSUV max (0.712, P &lt; 0.001), and hSUV max (0.555, P = 0.003) values. The absolute change in aSUV max value could accurately discriminate (area under the curve, 0.98; P = 0.001) European League Against Rheumatism responders from nonresponders. Conclusions 68 Ga-RGD 2 PET/CT is a promising tool for objective assessment of disease activity and treatment response in patients with RA.
Eus-Guided Choledocho-Duodenostomy Versus ERCP With Covered Metallic Stents in Patients With Unresectable Malignant Distal Biliary Obstruction. a Multi-Centered Randomized Controlled Trial (DRA-MBO TRIAL)
Authors: A Teoh, B Napoleon, R Kunda, P Arcidiacono, P Kongkam, A Larghi, Scd Merwe, J Jacques, R Legros, RE Thawee, A Kaffes, M Aerts, S Chan, P Chiu, F Fumex, N Messaoudi, K NG, E NG, G Rizzatti, P Saxna, J Lau
Journal: Endoscopy (2021)

Aims EUS – guided choledocho-duodenostomy (ECDS) is an established option for bile duct drainage in unresectable malignant distal common bile duct (CBD) strictures when endoscopic retrograde cholangiopancreatography (ERCP) fails. The aim of the current study is to compare primary ECDS versus ERCP with CSEMS in unresectable malignant distal CBD strictures.
Effects of calcium channel blocker on responses of blood flow, function, arrhythmias, and extent of infarction following reperfusion in conscious baboons.
Authors: S FVatner, T APatrick, D RKnight, W TManders, J TFallon
Journal: Circulation Research (1988)

Two groups of chronically instrumented, conscious baboons were studied. The effects of coronary artery occlusion for 3 hours and reperfusion for 1 week were examined on measurements of left ventricular function, ischemic-zone wall thickness, regional myocardial blood flow, arrhythmias, and extent of necrosis. The experimental group of animals (n = 7) was treated with the calcium channel blocker nisoldipine (0.1 microgram/kg/min) from 1 hour after coronary occlusion to 3 hours after coronary reperfusion. The control group (n = 6) received the vehicle (n = 4) or saline (n = 2). The effects of coronary artery occlusion and reperfusion on arterial pressure, left ventricular systolic pressure, heart rate, and left ventricular dP/dt were similar in both groups. Systolic wall thickening was reversed to paradoxical wall thinning during occlusion in both groups, and there was no recovery to systolic wall thickening over the 1-week period in either group. There were differences in regional blood flow; during corona...
A new method for measurement of sinoatrial conduction time.
Authors: O SNarula, NShantha, MVasquez, W DTowne, J WLinhart
Journal: Circulation (1978)

This study describes a new method (NM) for estimation of sinoatrial conduction time (SACT), which utilizes constant atrial pacing (AP) instead of the premature atrial beats (PABs) used in the method reported in 1973 by Strauss et al. The SACTs were obtained by both methods in 20 patients. The SACT by the Strauss method (SM) was calculated as A2A3 minus A1A1. The NM consists of high right AP for a train of eight consecutive beats at rates less than or equal to 10 beats/min faster than the sinus rhythm. The interval between the last paced atrial electrogram (Ap) and the first escape atrial electrogram (A) of sinus origin (Ap-A) was measured along with several post pacing sinus cycles. The SACT by the NM was calculated as follows: SACT = Ap-A minus A1A1. The effect of AP at higher rates was also analyzed. In two patients, the SACT with the SM could not be defined, as all the A2A3 intervals were fully compensatory; with the NM the SACT was 217 and 320 msec. In the remaining 18 patients the SACT was obtainable...
Dystrophin-glycoprotein complex and laminin colocalize to the sarcolemma and transverse tubules of cardiac muscle.
Authors: RKlietsch, J MErvasti, WArnold, K PCampbell, A OJorgensen
Journal: Circulation Research (1993)

The expression and subcellular distribution of the dystrophin-glycoprotein complex and laminin were examined in cardiac muscle by immunoblot and immunofluorescence analysis of rabbit and sheep papillary muscle. The five dystrophin-associated proteins (DAPs), 156-DAG, 59-DAP, 50-DAG, 43-DAG, and 35-DAG, were identified in rabbit ventricular muscle and found to codistribute with dystrophin in both papillary myofibers and Purkinje fibers. The DAPs and dystrophin codistributed not only in the free surface sarcolemma but also in interior regions of the myofibers where T tubules are present. Neither the DAPs nor dystrophin were detected in intercalated discs, a specialized region of cardiac sarcolemma where neighboring myocardial cells are physically joined by cell-cell junctions. Similarly, in bundles of Purkinje fibers, which lack T tubules, DAPs and dystrophin were also found to codistribute at the free surface sarcolemma but were not detected either in the region of surface sarcolemma closely apposed to a n...
Loss of nocturnal decline in blood pressure after cardiac transplantation.
Authors: R AReeves, A PShapiro, M EThompson, A MJohnsen
Journal: Circulation (1986)

Twenty-four hour noninvasive ambulatory blood pressure and heart rate monitoring was performed on patients who underwent orthotopic cardiac transplantation, as part of the investigation of the de novo hypertension that developes in such patients. Patients with essential hypertension served as control subjects. The results demonstrated a highly significant loss of the usual decline in blood pressure and heart rate during sleep in the transplant patients. A similar loss of nocturnal decline in blood pressure was noted in a group of 10 patients with autonomic neuropathy secondary to diabetes mellitus. The de novo hypertension associated with cardiac transplantation is probably multicausal. Impairment of renal function by cyclosporin-A with associated salt and water retention and persistent elevation of the systemic vascular resistance in the presence of a restored normal cardiac output by the new heart are major factors. In addition, loss of the normal nocturnal decline in blood pressure and heart rate, wh...
TCTAP C-111 Calcified Descending Aortic Dissection During TAVI
Authors: Faizal Khan Abdullah, Shaiful Azmi Yahaya, Kumara Gurupparan Ganesan, Jayakhanthan Kolanthaivelu, Wan Faizal Bin Wan Rahimi Shah, Afif Ashari, Faten Aqilah Binti Aris
Journal: Journal of the American College of Cardiology (2021)
Effective Compliance of the Total Vascular Bed and the Intrathoracic Compartment Derived from Changes in Central Venous Pressure Induced by Volume Changes in Man
Authors: MARTIN ECHT, JOHANNES DÜWELING, OTTO H. GAUER, LOTHAR LANGE
Journal: Circulation Research (1974)

In eight male subjects the blood volume was changed (± 10%) by hemorrhage and transfusion. One cycle of blood infusion and withdrawal or hemorrhage and reinfusion was completed within 9 minutes. The effective compliance of the total circulation was calculated from the changes in central venous pressure recorded simultaneously with the changes in blood volume. The effective compliance was 2.3 ml/mm Hg kg -1 body weight. This procedure was repeated while the capacity of the circulatory system was restricted by infusion of norepinephrine (15 µg/min), lower body positive pressure, or both. The compliance values thus obtained were: norepinephrine 1.7 ml/mm Hg kg -1 body weight, lower body positive pressure 1.2 ml/mm Hg kg -1 body weight, and both norepinephrine and lower body positive pressure 0.9 ml/mm Hg kg -1 body weight. The effective compliance of the intrathoracic vascular bed was assumed to be between 1.2 ml/mm Hg kg -1 body weight (lower body positive pressure) and 0.9 ml/mm Hg kg -1 body weight (norepinephrine and lower body positive pressure). These values constitute 55% and 42% of the effective compliance of the total circulation, respectively.
Value of physical signs in the diagnosis of ventricular tachycardia.
Authors: C JGarratt, M JGriffith, GYoung, NCurzen, SBrecker, A FRickards, A JCamm
Journal: Circulation (1994)

BACKGROUNDAlthough the use of physical signs for the diagnosis of ventricular tachycardia (VT) was described in the early 1900s, their value in this role has never been systematically assessed.METHODS AND RESULTSUsing a blinded, randomized protocol, we examined the ability of 26 clinicians to detect ventriculoatrial (VA)  during cardiac pacing in 21 patients with both atrial and ventricular pacing wires in situ after successful ablation of accessory pathways. In protocol 1 (10 patients), pacing was randomized to either ventricular pacing alone (simulating VT) or to atrioventricular sequential pacing (simulating supraventricular tachycardia or VT with intact  conduction) at rates of 150 or 180 beats per minute. Each patients was examined by four clinicians blinded to the pacing mode. Clinicians were asked to make a diagnosis of VA association or VA dissociation after examining the patient for variability of the arterial pulse, jugular venous pulse (JVP), and first heart sound. In protocol...
The Basolateral Polarity Module Promotes Slit Diaphragm Formation in Drosophila Nephrocytes, a Model of Vertebrate Podocytes
Authors: Michael Mysh, John S. Poulton
Journal: Journal of the American Society of Nephrology (2021)

Significance Statement Apical polarity proteins are key regulators of podocyte function, particularly with respect to slit diaphragm (SD) integrity. However, no experimental evidence demonstrates basolateral polarity proteins regulate SDs, suggesting apicobasal polarity in itself may not be important. Using Drosophila nephrocyte SDs as a model, this study reports the basolateral polarity module promotes SD integrity through roles in endocytic trafficking. These findings suggest apicobasal polarity proteins are cooperative regulators of SDs, and connect these polarity proteins to other pathways important for SD integrity. Background Podocyte slit diaphragms (SDs) are intercellular junctions that function as size-selective filters, excluding most proteins from urine. Abnormalities in SDs cause proteinuria and nephrotic syndrome. Podocytes exhibit apicobasal polarity, which can affect fundamental aspects of cell biology, including morphology, intercellular junction formation, and asymmetric protein distribution along the plasma membrane. Apical polarity protein mutations cause nephrotic syndrome, and data suggest apical polarity proteins regulate SD formation. However, there is no evidence that basolateral polarity proteins regulate SDs. Thus, the role of apicobasal polarity in podocytes remains unclear. Methods Genetic manipulations and transgenic reporters determined the effects of disrupting apicobasal polarity proteins in Drosophila nephrocytes, which have SDs similar to those of mammalian podocytes. Confocal and electron microscopy were used to characterize SD integrity after loss of basolateral polarity proteins, and genetic-interaction studies illuminated relationships among apicobasal polarity proteins. Results The study identified four novel regulators of nephrocyte SDs: Dlg, Lgl, Scrib, and Par-1. These proteins comprise the basolateral polarity module and its effector kinase. The data suggest these proteins work together, with apical polarity proteins, to regulate SDs by promoting normal endocytosis and trafficking of SD proteins. Conclusions Given the recognized importance of apical polarity proteins and SD protein trafficking in podocytopathies, the findings connecting basolateral polarity proteins to these processes significantly advance our understanding of SD regulation.
Adenosine-sensitive afterdepolarizations and triggered activity in guinea pig ventricular myocytes.
Authors: YSong, SThedford, B BLerman, LBelardinelli
Journal: Circulation Research (1992)

This study examines the cellular basis and specificity of the effects of adenosine on early afterdepolarizations (EADs), delayed afterdepolarizations (DADs), and triggered activity (TA) induced by various drugs with different mechanisms of action. Membrane potential and currents were measured in isolated guinea pig ventricular myocytes. Adenosine (10-100 microM) significantly (p less than 0.05) reduced the amplitude of DADs and suppressed TA induced by isoproterenol (10-50 nM) and forskolin (1 microM) but not those induced by dibutyryl cAMP (1 microM), ouabain (1-5 microM), and 7.2 mM [Ca2+]o. Adenosine also abolished EADs and TA induced by isoproterenol. In contrast, adenosine failed to abolish EADs and TA induced by quinidine (3 microM) or those that occurred spontaneously (i.e., in the absence of drugs). Transient inward current (ITi) was induced on repolarization after 2-second-long single depolarizing voltage steps or after 12-second-long trains of 300-msec depolarizing pulses. Concomitant with the a...
USP34 regulates tooth root morphogenesis by stabilizing NFIC
Authors: Shuang Jiang, Rui Sheng, Xingying Qi, Jun Wang, Yuchen Guo, Quan Yuan
Journal: International Journal of Oral Science (2021)

Abstract Tooth root morphogenesis involves two biological processes, root elongation and dentinogenesis, which are guaranteed by downgrowth of Hertwig’s epithelial root sheath (HERS) and normal odontoblast differentiation. Ubiquitin-dependent protein degradation has been reported to precisely regulate various physiological processes, while its role in tooth development is still elusive. Here we show ubiquitin-specific protease 34 (USP34) plays a pivotal role in root formation. Deletion of Usp34 in dental mesenchymal cells leads to short root anomaly, characterized by truncated roots and thin root dentin. The USP34 -deficient dental pulp cells (DPCs) exhibit decreased odontogenic differentiation with downregulation of nuclear factor I/C (NFIC). Overexpression of NFIC partially restores the impaired odontogenic potential of DPCs. These findings indicate that USP34-dependent deubiquitination is critical for root morphogenesis by stabilizing NFIC.
Lung cancer screening white paper: a slippery step forward?
Authors: Alberto Ruano-Ravina, Mariano Provencio-Pulla, Alberto Fernández-Villar
Journal: European Respiratory Journal (2015)

We have read with great interest the White Paper on lung cancer screening published jointly by the European Respiratory Society and the European Society of Radiology [1]. While it has some thoughtful insights, it also has some misconceptions. The recent white paper on lung cancer has some insights, but also some misconceptions <http://ow.ly/RZLmM>
Retrograde Enteroscopy with a Standard Colonoscope in a Patient of Obscure GI Bleed
Authors: H Raina
Journal: Endoscopy (2021)

A 62 year female presented with bleeding P/R for 3 months. EGD and colonoscopy done outside were normal. CECT showed a suspected thickening/lesion in the right lumber region. I did a colonoscopy and didn’t find any source of bleeding till caecal pole.I decided to intubate the ileum and to go as deep as possible with the same colonoscope as enteroscope was not available. I found a polypoidal tumor in the terminal ileum at about 60-70 cms from the I/C valve. I took biopsies and histopathology report came as adeno carcinoma. She underwent surgery and now patient is doing well.
Survival after coronary artery bypass surgery in specific patient groups.
Authors: G MLawrie, G CMorris
Journal: Circulation (1982)

The results of coronary bypass 5-10 years after operation at the Baylor College of Medicine are reported. The late results demonstrate that good relief of symptoms of angina pectoris persisted in 89% of patients at 10 years of follow-up. An overall annual attrition rate of 3% has been fairly constant through 10 years of follow-up. Graft patency has declined at a rate of about 1% per year after the first year, with patency rates in the 5-10-year interval approaching 80%. Pathologic changes in the vein grafts of intimal proliferation or atherosclerosis appear to pose a limited threat to long-term patency. Although derived from an early experience in which perioperative mortality was relatively high and revascularization incomplete, these favorable long-term results are encouraging.
Triggered ventricular rhythms in 1-day-old myocardial infarction in the dog.
Authors: NEl-Sherif, W BGough, R HZeiler, RMehra
Journal: Circulation Research (1983)

Triggered activity developed in depolarized Purkinje fibers (maximum diastolic potential -59.3 +/- 9.9 mV) during superfusion with normal Tyrode's solution in 84% of subendocardial preparations from 1-day-old canine infarct. Triggered activity occurred when a delayed afterdepolarization attained threshold potential and spontaneously terminated after a subthreshold delayed afterdepolarization. Triggered activity was initiated either by stimulated beats or by the background slow Purkinje automaticity. When multiple stimulated beats were required, the amplitude of the afterdepolarization increased and the coupling interval decreased when the stimulation frequency and/or the number of stimulated beats increased. Varying degrees of entrance and exit block around sites of triggered activity were common, and some triggered activity manifested as a parasystolic rhythm. In preparations showing subthreshold delayed afterdepolarizations, both epinephrine (2.5 x 10(-6) M) and increasing [Ca++]o, (from 2.7 to 8.1 mM) ...
Effects of inotropic and chronotropic stimuli on acute myocardial ischemic injury. I. Studies with dobutamine in the anesthetized dog.
Authors: R ERude, CIzquierdo, L MBuja, J TWillerson
Journal: Circulation (1982)

The effect of i.v. dobutamine on acute myocardial ischemic injury was assessed in 22 anesthetized dogs subjected to serial 10-minute occlusions of the left anterior descending coronary artery. The severity of ischemic injury was determined by mass spectrometric measurement of the increase in intramural carbon dioxide tension (delta PmCO2) in the ischemic zone. In the time protocol 1 dogs, dobutamine, 20 micrograms/kg/min, infused between the control and final occlusion, significantly increased both heart rate (HR) and left ventricular (LV) dP/dt; delta PmCO2 was significantly higher during the dobutamine infusion that during control occlusion (76 +/- 21 vs 56 +/- 13 mm Hg, p less than 0.01). The nine protocol 2 dogs were atrially paced at a HR of 20--30 beats/min above baseline values during the control occlusion and received dobutamine (12.6 +/- 7.8 micrograms/kg/min) at doses necessary to attain an equal HR (mean 149--154 beats/min) during the last occlusion. Although LV dP/dt was higher after dobutamin...
fMet-Leu-Phe receptor expression by an interstitial cell in rabbit right atrium following left ventricular myocardial infarction.
Authors: C GDunkel, J ESaffitz, A SEvers
Journal: Circulation Research (1989)

Previous studies have shown that rabbit hearts subjected to in vivo left ventricular myocardial infarction and subsequent ex vivo perfusion respond to N-formylmethionyl-leucyl-phenylalanine (fMLP) with enhanced eicosanoid synthesis. This synthetic response occurs primarily in the right cardiac atrium, a site distant from the injury, and is not the result of increased enzymatic capacity for arachidonate metabolism. To further investigate the mechanism of this enhanced synthetic response, [3H]fMLP binding was characterized and binding sites were localized autoradiographically in intact tissue sections prepared from control hearts and hearts subjected to left ventricular myocardial infarction (1, 2, and 4 days postinfarction). Analysis of binding isotherms revealed a saturable high affinity (KD approximately 1 nM) fMLP binding site in the right cardiac atrium. After myocardial infarction specific binding in right atria (2 day) increased 12-fold (Bmax = 14.8 +/- 2.4 fmol/cm2) compared with normal controls (Bm...