tbuckley/cabot-search huggingface dataset:
Liberation from Invasive Mechanical Ventilation with Continued Receipt of Vasopressor Infusions
Authors: Baharan Zarrabian, Hannah Wunsch, Henry T. Stelfox, Theodore J. Iwashyna, Hayley B. Gershengorn
Journal: American Journal of Respiratory and Critical Care Medicine (2022)

Rationale: Weaning protocols for discontinuation of invasive mechanical ventilation often mandate resolution of shock. Whether extubation while receiving vasopressors is associated with harm is uncertain. Objectives: To examine whether extubation while still receiving vasopressors is associated with worse outcomes. Methods: We performed a retrospective cohort study of adults in Calgary ICUs who received vasopressors with invasive mechanical ventilation and an extubation attempt. The primary exposure was continued vasopressor use at extubation. The primary outcome was reintubation within 96 hours. Secondary outcomes included in-hospital mortality and ICU/hospital length of stay (LOS). We assessed associations of vasopressor use at extubation with outcomes using multivariable competing-risk (reintubation/LOS) and Cox proportional-hazards (mortality) models. Measurements and Main Results: Of 6,140 patients who received invasive mechanical ventilation while on vasopressors, 721 (11.7%) were extubated while receiving vasopressors, and 5,419 (88.3%) after discontinuation. Extubation on vasopressors was not, in aggregate, significantly associated with an increased hazard of reintubation (subhazard ratio [SHR], 1.81 [95% confidence interval, 0.91-3.61]; P = 0.09). Both mortality (hazard ratio, 1.22 [1.02-1.47]; P = 0.03) and time to hospital discharge (SHR for remaining hospitalized, 0.78 [0.68-0.91]; P < 0.01) were increased. Extubation on high-dose vasopressors (>0.1 μg/kg/min) was associated with a greater hazard of reintubation (SHR, 2.25 [1.01-4.98]; P = 0.046) compared with extubation after vasopressor discontinuation. Meanwhile, extubation on low-dose vasopressors (⩽0.1 μg/kg/min) was associated with a lower mortality (hazard ratio, 0.69 [0.51-0.91]; P = 0.01) and a shorter ICU LOS (SHR, 1.34 [1.09-1.65]; P = 0.01), but no difference in reintubation or hospital LOS as compared with those weaned off vasopressors. Conclusions: Extubation while receiving high-dose but not low-dose vasopressors was associated with an increased risk of reintubation.
AGA Clinical Practice Update on the Personalized Approach to the Evaluation and Management of GERD: Expert Review
Authors: Rena Yadlapati, C. Prakash Gyawali, John E. Pandolfino, Kenneth Chang, Peter J. Kahrilas, Philip O. Katz, David Katzka, Sri Komanduri, John Lipham, Paul Menard-Katcher, V. Raman Muthusamy, Joel Richter, Virender K. Sharma, Michael F. Vaezi, Sachin Wani
Journal: Clinical Gastroenterology and Hepatology (2022)
CANNED ROAST BEEF.
Journal: JAMA (1899)

The Court of Inquiry into the character of the canned and refrigerated meat issued last year to the troops in Cuba and Porto Rico is nearing the end of its work. The court was convened by an order of the War Department, dated Feb. 9, 1899, to investigate "certain allegations of the major-general commanding the army in respect to the unfitness for issue of certain articles of food furnished by the subsistence department to the troops in the field during the recent operations in Cuba and Porto Rico." In addition to findings of fact, it was directed to submit an opinion upon the merits of the case together with such recommendations as to further proceedings as may seem to be warranted by the facts developed in the course of the inquiry. The questions before the court appear to involve the propriety of the action of the major-general commanding, the loyalty,
皮肤局部产生的抑制肽在化脓性汗腺炎中的作用
Journal: British Journal of Dermatology (2022)

Journal Article 皮肤局部产生的抑制肽在化脓性汗腺炎中的作用 Get access British Journal of Dermatology, Volume 186, Issue 2, 1 February 2022, Page e109, https://doi.org/10.1111/bjd.20937 Published: 01 February 2022
Classified Advertising
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PSD3 downregulation confers protection against fatty liver disease
Authors: Rosellina M. Mancina, Kavitha Sasidharan, Anna Lindblom, Ying Wei, Ester Ciociola, Oveis Jamialahmadi, Piero Pingitore, Anne-Christine Andréasson, Giovanni Pellegrini, Guido Baselli, Ville Männistö, Jussi Pihlajamäki, Vesa Kärjä, Stefania Grimaudo, Ilaria Marini, Marco Maggioni, Barbara Becattini, Federica Tavaglione, Carly Dix, Marie Castaldo, Stephanie Klein, Mark Perelis, Francois Pattou, Dorothée Thuillier, Violeta Raverdy, Paola Dongiovanni, Anna Ludovica Fracanzani, Felix Stickel, Jochen Hampe, Stephan Buch, Panu K. Luukkonen, Daniele Prati, Hannele Yki-Järvinen, Salvatore Petta, Chao Xing, Clemens Schafmayer, Elmar Aigner, Christian Datz, Richard G. Lee, Luca Valenti, Daniel Lindén, Stefano Romeo
Journal: Nature Metabolism (2022)

Abstract Fatty liver disease (FLD) is a growing health issue with burdening unmet clinical needs. FLD has a genetic component but, despite the common variants already identified, there is still a missing heritability component. Using a candidate gene approach, we identify a locus (rs71519934) at the Pleckstrin and Sec7 domain-containing 3 ( PSD3 ) gene resulting in a leucine to threonine substitution at position 186 of the protein (L186T) that reduces susceptibility to the entire spectrum of FLD in individuals at risk. PSD3 downregulation by short interfering RNA reduces intracellular lipid content in primary human hepatocytes cultured in two and three dimensions, and in human and rodent hepatoma cells. Consistent with this, Psd3 downregulation by antisense oligonucleotides in vivo protects against FLD in mice fed a non-alcoholic steatohepatitis-inducing diet. Thus, translating these results to humans, PSD3 downregulation might be a future therapeutic option for treating FLD.
TIRAP drives myelosuppression through an Ifnγ–Hmgb1 axis that disrupts the endothelial niche in mice
Authors: Aparna Gopal, Rawa Ibrahim, Megan Fuller, Patricia Umlandt, Jeremy Parker, Jessica Tran, Linda Chang, Joanna Wegrzyn-Woltosz, Jeffrey Lam, Jenny Li, Melody Lu, Aly Karsan
Journal: The Journal of Experimental Medicine (2022)

Inflammation is associated with bone marrow failure syndromes, but how specific molecules impact the bone marrow microenvironment is not well elucidated. We report a novel role for the miR-145 target, Toll/interleukin-1 receptor domain containing adaptor protein (TIRAP), in driving bone marrow failure. We show that TIRAP is overexpressed in various types of myelodysplastic syndromes (MDS) and suppresses all three major hematopoietic lineages. TIRAP expression promotes up-regulation of Ifnγ, leading to myelosuppression through Ifnγ-Ifnγr-mediated release of the alarmin, Hmgb1, which disrupts the bone marrow endothelial niche. Deletion of Ifnγ blocks Hmgb1 release and is sufficient to reverse the endothelial defect and restore myelopoiesis. Contrary to current dogma, TIRAP-activated Ifnγ-driven bone marrow suppression is independent of T cell function or pyroptosis. In the absence of Ifnγ, TIRAP drives myeloproliferation, implicating Ifnγ in suppressing the transformation of MDS to acute leukemia. These findings reveal novel, noncanonical roles of TIRAP, Hmgb1, and Ifnγ in the bone marrow microenvironment and provide insight into the pathophysiology of preleukemic syndromes.
<i>ERJ</i>Podcast March 2019: Novel therapies in idiopathic pulmonary fibrosis
Journal: European Respiratory Journal (2019)

As part of the March issue, the European Respiratory Journal presents the latest in its series of podcasts. Chief Editor Martin Kolb interviews Toby Maher (Royal Brompton Hospital and Imperial College London, UK) about two articles in this issue reporting the results of randomised controlled trials in idiopathic pulmonary fibrosis.
The Diseases of the Stomach.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Study of Diabetic Syndrome in Rats Produced by Anti-Insulin
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Venous Thromboembolism in Chronic Inflammatory Skin Diseases—The Need to Consider Bullous Pemphigoid—Reply
Authors: Maria C. Schneeweiss, Jonathan I. Silverberg, Arash Mostaghimi
Journal: JAMA Dermatology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Atrial shunt device for heart failure with preserved and mildly reduced ejection fraction (REDUCE LAP-HF II): a randomised, multicentre, blinded, sham-controlled trial
Authors: Sanjiv J Shah, Barry A Borlaug, Eugene S Chung, Donald E Cutlip, Philippe Debonnaire, Peter S Fail, Qi Gao, Gerd Hasenfuß, Rami Kahwash, David M Kaye, Sheldon E Litwin, Philipp Lurz, Joseph M Massaro, Rajeev C Mohan, Mark J Ricciardi, Scott D Solomon, Aaron L Sverdlov, Vijendra Swarup, Dirk J van Veldhuisen, Sebastian Winkler, Martin B Leon, Joseph Akar, Jiro Ando, Toshihisa Anzai, Masanori Asakura, Steven Bailey, Anupam Basuray, Fabrice Bauer, Martin Bergmann, John Blair, Jeffrey Cavendish, Eugene Chung, Maja Cikes, Ira Dauber, Erwan Donal, Jean-Christophe Eicher, Peter Fail, James Flaherty, Xavier Freixa, Sameer Gafoor, Zachary Gertz, Robert Gordon, Marco Guazzi, Cesar Guerrero-Miranda, Deepak Gupta, Finn Gustafsson, Cyrus Hadadi, Emad Hakemi, Louis Handoko, Moritz Hass, Jorg Hausleiter, Christopher Hayward, Gavin Hickey, Scott Hummel, Imad Hussain, Richard Isnard, Chisato Izumi, Guillaume Jondeau, Elizabeth Juneman, Koichiro Kinugawa, Robert Kipperman, Bartek Krakowiak, Selim Krim, Joshua Larned, Gregory Lewis, Erik Lipsic, Anthony Magalski, Sula Mazimba, Jeremy Mazurek, Michele McGrady, Scott Mckenzie, Shamir Mehta, John Mignone, Hakim Morsli, Ajith Nair, Thomas Noel, James Orford, Kishan Parikh, Tiffany Patterson, Martin Penicka, Mark Petrie, Burkert Pieske, Martijn Post, Philip Raake, Alicia Romero, John Ryan, Yoshihiko Saito, Takafumi Sakamoto, Yasushi Sakata, Michael Samara, Kumar Satya, Andrew Sindone, Randall Starling, Jean-Noël Trochu, Bharathi Upadhya, Jan van der Heyden, Vanessa van Empel, Amit Varma, Amanda Vest, Tobias Wengenmayer, Ralf Westenfeld, Dirk Westermann, Kazuhiro Yamamoto, Andreas Zirlik
Journal: The Lancet (2022)
On teaching an old dog new tricks
Authors: S. Vaisrub
Journal: JAMA (1978)

The physician who, in keeping with stereotyped jokes, puts off a night visit by instructing the caller to take aspirin may no longer be able to do so. The distressed caller may already be taking the drug as a participant in a cohort study of its efficacy in preventing thrombosis. A number of these studies have been initiated since the discovery that aspirin inhibits platelet aggregation. Although some of them relate to the peripheral vasculature,<sup>1</sup>the majority address themselves to thrombosis in the coronary and the cerebral circulation. A report of one such study, the randomized prospective Coronary Drug Project Aspirin Study,<sup>2</sup>disclosed a substantially lower death rate in the aspirin- than in the placebo-treated group. In a more recent, retrospective, case-controlled study, Hennekens et al<sup>3</sup>found no association between the frequent use of aspirin and the mortality from coronary heart disease. Still in progress are the Aspirin
Corticotropin-Releasing Hormone: Clinical Applications
Authors: L. Nieman
Journal: Annual Review of Medicine (1989)

CD40 is a cell-surface member of the TNF (tumor necrosis factor) receptor superfamily. Upon activation, CD40 can license dendritic cells to promote antitumor T cell activation and re-educate macrophages to destroy tumor stroma. Numerous agonist CD40 ...Read More
Economics
Authors: Uwe E. Reinhardt
Journal: JAMA (1996)

Breakthroughs in the sciences often take the form of replacing 1 hitherto held hypothesis with another. In the social sciences, that process tends to be controversial, because hypotheses usually can be tested only on crude, nonexperimental data that tend to be compatible with numerous rival hypotheses (theories). More often than not, the individual social scientist's allegiance to this or that theory is dictated by that individual's personal predilections.<sub>1</sub>A "breakthrough" in the social sciences, therefore, may be nothing more than the triumph of 1 ideology over another. During the past decade or so, economics experienced such a breakthrough. Certain theories favored by large segments of the profession, the ideology they embodied, and the felicitous jargon they inspired came to dominate the thrust of American health care policy. Goaded in good part by the writings, teaching, and punditry of economists, American politicians increasingly treated health care as just another private
cGAS/STING cross-talks with cell cycle and potentiates cancer immunotherapy
Authors: Zi-Jie Long, Jun-Dan Wang, Jue-Qiong Xu, Xin-Xing Lei, Quentin Liu
Journal: Molecular Therapy (2022)

The correct duplication and transfer of genetic material to daughter cells is the major event of cell division. Dysfunction of DNA replication or chromosome segregation presents challenges in cancer initiation and development as well as opportunities for cancer treatment. Cyclic GMP-AMP synthase (cGAS) of the innate immune system detects cytoplasmic DNA and mediates downstream immune responses through the molecule stimulator of interferon genes (STING). However, how cytosolic DNA sensor cGAS participates in guaranteeing accurate cell division and preventing tumorigenesis is still unclear. Recent evidence indicates malfunction of cGAS/STING pathway in cancer progression. Cell cycle-targeted therapy synergizes with immunotherapy via cGAS/STING activation, leading to promising therapeutic benefit. Here, we review the interactions between cell cycle regulation and cGAS/STING signaling, thus enabling us to understand the role of cGAS/STING in cancer initiation, development, and treatment.
HIV VACCINES
Authors: Andrew J. McMichael
Journal: Annual Review of Immunology (2005)

A prophylactic vaccine for HIV-1 is badly needed. Despite 20 years of effort, it is still a long way off. However, considerable progress has been made in understanding the problem. The virus envelope has evolved to evade neutralizing antibodies in an extraordinary way, yet a vaccine that can stimulate such antibodies remains the best hope. Anti-HIV-1 T cell responses are evaded by continuous mutation of the virus. Vaccine strategies that concentrate on stimulating T cell immunity will at best generate broadly reactive and persisting T cell responses that can suppress virus without preventing infection, limiting or preventing the damage the virus causes. The SIV macaque models give encouragement that this is possible, but they need further understanding. Therapeutic vaccination should also be considered.
Longitudinal analyses of development of the immune system during the first five years of life in relation to lifestyle
Authors: Axel Olin, Nathalie Acevedo, Tadepally Lakshmikanth, Yang Chen, Catharina Johansson, Johan Alm, Annika Scheynius, Petter Brodin
Journal: Allergy (2022)

Abstract Background Changes in immune cell composition during the immunological window within the first years after birth are not fully understood, especially the effect that different lifestyles might have on immune cell functionality. Methods Peripheral blood mononuclear cells from mothers and their children at birth and at two anvd five years were analyzed by mass cytometry. Immune cell composition and functionality was analyzed according to family lifestyle (anthroposophic and non‐anthroposophic). Results We found no significant differences in the proportions of major immune lineages between anthroposophic and non‐anthroposophic children at each time point, but there were clear changes over time in the proportions of mononuclear leukocytes, especially in B‐cells and T lymphocytes. Phenotypic distances between cord blood and maternal blood were high at birth but decreased sharply the first two years, indicating strong phenotypic convergence with maternal cells. We found that children exhibited similar stimulation responses at birth, but subsequently segregated into two discrete functional trajectories. Trajectory 1 was associated with a decrease in tumor necrosis factor alpha (TNFa) production by CD4 + T‐ and NK‐cells, while Trajectory 2 depicted an increase in the production of IL‐2 and interferon gamma (INFg) by T‐cells. In both trajectories, there was an increase in IL‐17A production by T‐cells resulting in prominent differences at five years of age. Conclusions This exploratory study suggests that leukocyte frequencies and cell phenotypes change with age in the same way across all children, while functional development follows one of two discrete trajectories that largely segregate by family lifestyle, supporting the hypothesis that early environmental exposures imprint immune cell function which may contribute to IgE sensitization. Our results also support that the first two years are critical for the environmental exposures to imprint the immune cells. Further studies with larger sample sizes are required to validate our findings.
Climate change and health: on the latest IPCC report
Authors: Alistair Woodward, Kirk R Smith, Diarmid Campbell-Lendrum, Dave D Chadee, Yasushi Honda, Qiyong Liu, Jane Olwoch, Boris Revich, Rainer Sauerborn, Zoë Chafe, Ulisses Confalonieri, Andy Haines
Journal: The Lancet (2014)
Tau Mutations Serve as a Novel Risk Factor for Cancer
Authors: Giacomina Rossi, Veronica Redaelli, Paolo Contiero, Sabrina Fabiano, Giovanna Tagliabue, Paola Perego, Luisa Benussi, Amalia C. Bruni, Graziella Filippini, Mariangela Farinotti, Giorgio Giaccone, Simona Buiatiotis, Claudia Manzoni, Raffaele Ferrari, Fabrizio Tagliavini
Journal: Cancer Research (2018)

In addition to its well-recognized role in neurodegeneration, tau participates in maintenance of genome stability and chromosome integrity. In particular, peripheral cells from patients affected by frontotemporal lobar degeneration carrying a mutation in tau gene (genetic tauopathies), as well as cells from animal models, show chromosome numerical and structural aberrations, chromatin anomalies, and a propensity toward abnormal recombination. As genome instability is tightly linked to cancer development, we hypothesized that mutated tau may be a susceptibility factor for cancer. Here we conducted a retrospective cohort study comparing cancer incidence in families affected by genetic tauopathies to control families. In addition, we carried out a bioinformatics analysis to highlight pathways associated with the tau protein interactome. We report that the risk of developing cancer is significantly higher in families affected by genetic tauopathies, and a high proportion of tau protein interactors are involved in cellular processes particularly relevant to cancer. These findings disclose a novel role of tau as a risk factor for cancer, providing new insights in the various pathologic roles of mutated tau.Significance: This study reveals a novel role for tau as a risk factor for cancer, providing new insights beyond its role in neurodegeneration. Cancer Res; 78(13); 3731-9. ©2018 AACR.
Dupilumab improves objective, subjective, and health-related quality of life outcomes in chronic rhinosinusitis with nasal polyps (CRSwNP), regardless of BMI ≥30 kg/m2 or weight ≥90 kg: post-hoc analysis of the SINUS-24 and SINUS-52 studies
Authors: Seong Cho, Bruce Tan, Noam Cohen, Jody Tversky, Elina Toskala, Scott Nash, Haixing Zhang, Shahid Siddiqui, Asif Khan, Juby Jacob-Nara, Paul Rowe, Yamo Deniz
Journal: Journal of Allergy and Clinical Immunology (2022)