tbuckley/cabot-search huggingface dataset:
A place in the sun?
Authors: I. Ben-Shlomo, G. Goodman
Journal: BMJ (1988)

To find out if the Scottish national dish, haggis, contributes to the high incidence of coronary heart disease in Scotland the lipaemic effect of a meal of 200 g of haggis was measured in six Scottish and 10 Sassenach men.The Scots had higher fasting cholesterol and triglyceride concentrations and a lower proportion of high density lipoprotein cholesterol than the Sassenachs.Four subjects were found to have hyperlipoproteinaemia, which had been unrecognised previously.Serum cholesterol con- centrations did not change after haggis was eaten (mean dose 2-6 gfkg body weight).Serum concentra- tions of triglycerides increased by 51% at 90 minutes in the Sassenachs but were unaltered in the Scots.There were.noserious adverse effects.This study shows that Scots have higher lipid con- centrations than Sassenachs but seem to be resistant to the lipaemic effect ofhaggis.The haggis tolerance test may be useful in Sassenachs.
The Case | Hypereosinophilia in a hemodialysis patient
Authors: Gaspard Lamy, Jean-Emmanuel Kahn, Tessa Huscenot, Mathilde Dargelos, Eve Vilaine, Aymeric Couturier, Panha Chhom, Hamza Ayari, Ziad Albert Massy, Marie Essig
Journal: Kidney International (2022)
Update in Virology and Radiology—Impact on Diagnosis and Treatment Conference
Journal: JNCI Journal of the National Cancer Institute (1984)

Update in Virology and Radiology—Impact on Diagnosis and Treatment Conference Get access JNCI: Journal of the National Cancer Institute, Volume 72, Issue 3, March 1984, Page 769, https://doi.org/10.1093/jnci/72.3.769-b Published: 01 March 1984
Hospitalizations and Deaths Associated with EVALI
Authors: Angela K. Werner, Emilia H. Koumans, Kevin Chatham-Stephens, Phillip P. Salvatore, Christina Armatas, Paul Byers, Charles R. Clark, Isaac Ghinai, Stacy M. Holzbauer, Kristen A. Navarette, Melissa L. Danielson, Sascha Ellington, Erin D. Moritz, Emily E. Petersen, Emily A. Kiernan, Grant T. Baldwin, Peter Briss, Christopher M. Jones, Brian A. King, Vikram Krishnasamy, Dale A. Rose, Sarah Reagan-Steiner
Journal: New England Journal of Medicine (2020)

As of January 7, 2020, a total of 2558 hospitalized patients with nonfatal cases and 60 patients with fatal cases of e-cigarette, or vaping, product use-associated lung injury (EVALI) had been reported to the Centers for Disease Control and Prevention (CDC).In a national study, we compared the characteristics of patients with fatal cases of EVALI with those of patients with nonfatal cases to improve the ability of clinicians to identify patients at increased risk for death from the condition. Health departments reported cases of EVALI to the CDC and included, when available, data from medical-record abstractions and patient interviews. Analyses included all the patients with fatal or nonfatal cases of EVALI that were reported to the CDC as of January 7, 2020. We also present three case reports of patients who died from EVALI to illustrate the clinical characteristics common among such patients.Most of the patients with fatal or nonfatal cases of EVALI were male (32 of 60 [53%] and 1666 of 2498 [67%], respectively). The proportion of patients with fatal or nonfatal cases was higher among those who were non-Hispanic white (39 of 49 [80%] and 1104 of 1818 [61%], respectively) than among those in other race or ethnic groups. The proportion of patients with fatal cases was higher among those 35 years of age or older (44 of 60 [73%]) than among those younger than 35 years, but the proportion with nonfatal cases was lower among those 35 years of age or older (551 of 2514 [22%]). Among the patients who had an available medical history, a higher proportion of those with fatal cases than those with nonfatal cases had a history of asthma (13 of 57 [23%] vs. 102 of 1297 [8%]), cardiac disease (26 of 55 [47%] vs. 115 of 1169 [10%]), or a mental health condition (32 of 49 [65%] vs. 575 of 1398 [41%]). A total of 26 of 50 patients (52%) with fatal cases had obesity. Half the patients with fatal cases (25 of 54 [46%]) were seen in an outpatient setting before hospitalization or death.Chronic conditions, including cardiac and respiratory diseases and mental health conditions, were common among hospitalized patients with EVALI.
Hospital staffing.
Authors: G I Da Costa
Journal: BMJ (1972)

district units and community services develop.Finally, as to training and recruitment, the experience in our region should reassure Drs.Bleaden and Price.Several general hospital units train most successfully their psychiatric nurses in conjunction with neigh- bouring mental hospitals.Many psychiatric nurses proceed with their training in the general hospital to ultimately reach the top of the Salmon ladder.It is somewhat disconcerting that most severe criticism of our regional policy comes from people who have never worked here.-Weare, etc.,
Deaths
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Image of the Month—Diagnosis
Journal: JAMA Surgery (2013)

Incarcerated Inguinal HerniaT he computed tomographic scan findings were consistent with an incarcerated right inguinal hernia with acute appendicitis in the hernia sac.A laparoscopic appendectomy was performed, an inflamed internal ring was found, and a temporary repair was performed by dissecting and suturing a portion of the adjacent lateral vesicoumbilical ligament to the internal inguinal ring (Figure 3).A 1-cm T1a appendiceal carcinoid tumor was found.The patient returned to the operating room 6 weeks later for exploratory laparoscopy; no additional evidence of malignancy was found, and the primary hernia repair was adequate.He underwent a formal transabdominal preperitoneal repair with mesh, and his recuperation was uneventful.An inguinal hernia is termed an Amyand hernia if the hernia sac comprises or contains the appendix.To our knowledge, the presence of an appendiceal carcinoid tumor presenting as a case of incarcerated Amyand hernia has not been reported in the literature.We report the first case of this unusual presentation.Amyand hernia has frequently been reported in younger (Ͼ2 years) and older (Ͼ60 years) individuals. 1,2A preoperative diagnosis is rare; more often, the diagnosis is made during surgery. 3Amyand hernia may mimic entirely different disease processes; therefore, a high index of suspicion is warranted.In the literature, the clinical presentations vary greatly: from the most common right-sided hernia, 2,4,5 to a left-sided hernia, 6 an incarcerated inguinal hernia, testicular torsion, 7,8 to the extremes of necrotizing fasciitis and shock. 9,10The contents of a hernia can be a normal-appearing, an inflamed, or a perforated appendix.Malignancy is extremely rare, with only 2 case reports of adenocarcinoma of the appendix. 11,12To the best of our knowledge, this is the first case of the presence of an appendiceal carcinoid tumor in an Amyand hernia.Appendiceal carcinoids comprise 1% of
Clinical Lectures on Mental and Cerebral Diseases
Authors: J. C. Browne
Journal: BMJ (1872)

III.-SIMPLE MELANCHOLIA.-( Concluded.) TURNING to the bodily symptoms of simple melancholia, I need scarcely tell you that these are infinitely varied.As the despondency may be but the outgrowth of some visceral or constitutional disease, it may have corresponding with it any of those groups of bodily symp.toms which attend upon the visceral or constitutional diseases out of which it may arise.Thus in Emma B., in Ward 28, the bodily symp- toms of simple melancholia are those which are recognised as charac- teristic of morbus Addisonii; while in Anne C., Ward 25, they are those of chronic rheumatism and valvular disease of the heart.
"Q" Fever
Authors: J. Mackay-Dick
Journal: BMJ (1947)

The vomiting ceased within 24 or at the most 48 hours, while the diarrhoea, which was of frequent, offensive, watery stools without- out blood or mucus, lasted two to three days, exceptionally four or more.In a few the onset was severe with marked prostration.Orre-fifth of the cases had no vomiting.Each case had a minimum of 3 stool cultures, 201 specimens in all being examined.No organism of the enteric, dysentery, or salmonella groups was found except in one case.This patient's illness lasted longer than usualnamely, 7 days.On the first, fourth, and eighteenth days from the onset her stool was negative; on the twenty-fourth day Salm.typhi- miurium was isolated.She was the only patient to have a further attack (not shown in these figures), which occurred two months after 1 .I s.Phtllo1ylsdhpbalWiczce 1Gc.ta.s.U PhtholusuhcLtsluazole 6.-t W 1 1 I I 4 05 4-L3Jar& Z3 _ SulphWguani&cS 2 3 4 5 6 7 B 9 10 11 it 1Z 5-i6I7 i8i9 9o 22 436i27269 31;M7I' Days of Outbrecak the first, when her stools were again negative.Widal tests from this patient and 6 others on Sept. 17 were negative.The following organisms were also identified, the numbers in brackets referring to cases: Morgan's bacillus 1 (4), Morgan's bacillus 2 (1), paracolon- bacillus type (4), B. faecalis alkaligenes (1).All cases were immediately isolated, discovery frequently depending entirely on the nurses' observation.In all but the infirmary ward strict isolation of individual patients could be enforced.Treatment was on the usual lines, with initial starvation and gradual return to normal of the diet by the fourth or fifth day.Attempts to increase the diet more quickly led to recurrence of the diarrhoea.Some cases were given phthalylsulphathiazole 3 g.daily without marked effect on symptoms or duration.However, sulphaguanidine and phthalylsuiphathiazole were tried as prophylactics, as shown in the table and diagram.The results were encouraging. Popula-~~No.
Annals Graphic Medicine - Select Your Next Move
Authors: Mohamed Taha
Journal: Annals of Internal Medicine (2020)

Web Exclusives21 April 2020Annals Graphic Medicine - Select Your Next MoveFREEMohamed Taha, MDMohamed Taha, MDManama, Bahrain (M.T.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/G19-0046 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Download figure Download PowerPoint Download figure Download PowerPoint Download figure Download PowerPoint Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: Manama, Bahrain (M.T.)Disclosures: The author has disclosed no conflicts of interest. The form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=G19-0046.Author/Illustrator Information: Mohamed Taha, MD (e-mail, moe.n.[email protected]com).This article was published at Annals.org on 14 April 2020. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 21 April 2020Volume 172, Issue 8Page: W102-W105KeywordsConflicts of interestDisclosureHealth care ePublished: 14 April 2020 Issue Published: 21 April 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Electrical Safety in the Operating Room
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
INTRODUCTION
Authors: MORRIS FISHBEIN
Journal: JAMA (1935)

In 1924 a series of articles—published in book form the following year and revised in 1927—was prepared under the auspices of the Council on Pharmacy and Chemistry of the American Medical Association with the general title "Glandular Therapy." In a brief introduction to that series Dr. Frank Billings emphasized certain significant factors in relationship to our knowledge of the glands which at that time many endocrinologists considered as established but which to some physiologists and clinicians were not quite acceptable. The points to which he referred concerned the alleged reciprocal action of the glands of internal secretion; i. e., the idea that the glands represent an interlocking chain of structures correlated in their activities through hormones carried in the blood stream. This led to the view that the entire functioning of the body might be stimulated, retarded or perverted by hyperfunction, hypofunction or alleged dysfunction of the ductless glands. It
Abstract 29: A Neighborhood Local Volunteer Response Network Improves Response Time for Cardiac Arrest
Authors: Karl B Kern, Carter Newton, Charles " Wunder, Thomas P Colberg, Marvin J Slepian
Journal: Circulation (2018)

Background: Minutes are crucial in the treatment of out-of-hospital cardiac arrest (CA). Immediate chest compressions and early defibrillation are keys to good outcomes. Local neighborhood volunteer (vol) response programs may decrease delays to early CPR and AED use. We hypothesized that a coordinated effort of alerting trained neighborhood vols simultaneously with 911 activation of professional EMS providers would provide earlier CPR and defibrillation in such communities. Methods: We developed a program of simultaneously alerting CPR and AED trained neighborhood vols and the local EMS system for cardiac arrest events in a retirement community in Southern Arizona, encompassing approximately 17,300 homes and 21,500 residents. EMS services are provided by 5 stations within the community boundaries. Within a single housing development neighborhood, 9 vols and the closest EMS station were involved in 3 days of mock CA notifications (total of 12 different alerts at various times during daytime hours were sent). This provided a total of 120 response opportunities, 12 for EMS and 108 for vols. The distance to the mock event and the time from alert to arrival were recorded and compared. Results: In the selected 55+ neighborhood, the two groups differed significantly in both distance to the mock cardiac arrest event and in response times. The volunteers average 0.33±0.19 miles from the mock CA incidences while the closest EMS station was 3.3 miles from the tested neighborhood (p&lt;0.0001). Response times (time from call to arrival) were also different. The earliest Vol arrived at 1min 30sec±48sec*, 2 Vols &amp; AED at 1min 38 sec±53sec*, all arriving Vols at 3min 23 sec*, and EMS at 7min 20 sec±1min 13sec (*p&lt;0.0001 vs EMS). Conclusion: When the neighborhood volunteers in this testing period were geographically closer to the mock CA event, they arrived significantly sooner to the scene than did the EMS service. The mean time of arrival for at least 2 vols with an AED was 5 min 42 sec faster than the professional rescuers. The implications for such a time saving could be as much as a 240% increase (25% to 85%) in survival for those with shockable rhythms.
JAMA Neurology
Journal: JAMA Neurology (2013)

The mission of JAMA Neurology is to publish scientific information primarily important for those physicians caring for people with neurologic disorders but also for those interested in the structure and function of the normal and diseased nervous system.These specific aims are (1) to make timely publication of original research of the nervous system, (2) to record observations of single patients or groups of patients that will provide new information and insights,(3) to report more basic research that is pertinent to the understanding of disease, (4) to introduce topics of practice, ethics, teaching, and history that are useful, (5) to provide a forum for discussion on topics that may be controversial in this field.This information will be published only after extensive peer review so that originality, clarity, and precision are ensured.
PSMAfore: A phase 3 study to compare <sup>177</sup>Lu-PSMA-617 treatment with a change in androgen receptor pathway inhibitor in taxane-naïve patients with metastatic castration-resistant prostate cancer.
Authors: A. Oliver Sartor, Michael J. Morris, Kim N. Chi, Johann S. De Bono, Neal D. Shore, Michael Crosby, Teri Nguyen Kreisl, Karim Fizazi
Journal: Journal of Clinical Oncology (2022)

TPS211 Background: [ 177 Lu]Lu-PSMA-617 ( 177 Lu-PSMA-617) is a high-affinity prostate-specific membrane antigen (PSMA)-targeted radioligand therapy that delivers β-particle radiation to PSMA-expressing cells and their surrounding microenvironment. In the phase 3 VISION trial, 177 Lu-PSMA-617 significantly prolonged radiographic progression-free survival (rPFS) and overall survival (OS) in patients with metastatic castration-resistant prostate cancer (mCRPC) previously treated with ≥1 androgen receptor pathway inhibitor (ARPI) and 12 taxanes. PSMAfore is investigating the effect on rPFS in taxane-naïve patients with mCRPC treated with either 177 Lu-PSMA-617 or a change in ARPI. Methods: PSMAfore (NCT04689828) is a multicenter, open-label, randomized phase 3 trial in adults with progressive mCRPC and confirmed PSMA expression by [ 68 Ga]Ga-PSMA-11 PET/CT. Eligible patients are taxane-naïve in the metastatic setting and have: received one prior ARPI and are candidates for a change in ARPI; an Eastern Cooperative Oncology Group performance status of 0 or 1; a castrate level of serum/plasma testosterone ( &lt; 50 ng/dL or &lt; 1.7 nmol/L); and recovered to grade ≤2 from toxicities related to prior therapies. Approximately 450 patients will be randomized 1:1 to receive 177 Lu-PSMA-617 (7.4 GBq i.v. every 6 weeks for 6 cycles) or a change in ARPI to either abiraterone or enzalutamide. Best supportive care is allowed in both arms. Stratification factors are prior ARPI use in castration-resistant vs hormone-sensitive prostate cancer settings and pain symptomatology (score 03 vs 410 on the worst pain intensity item of the Brief Pain InventoryShort Form). The primary endpoint is rPFS according to PCWG3-modified RECIST v1.1 criteria. Participants with blinded independent centrally confirmed radiographic progression in the ARPI arm can crossover to the 177 Lu-PSMA-617 arm. The planned sample size provides 95% power to detect a hazard ratio of 0.56 for rPFS after 156 events with an overall one-sided significance level of 0.025. The key secondary endpoint is OS; other secondary endpoints include safety and tolerability of 177 Lu-PSMA-617 and health-related quality of life. Previously presented at the 2021 European Society for Medical Oncology Congress, FPN 942, Morris M et al. Reused with permission. Clinical trial information: NCT04689828.
Effects of olympic style taekwondo kicks on an instrumented head-form and resultant head injury measures
Authors: G Fife, W Pieter, D O'sullivan, D Cook, T Kaminski
Journal: British Journal of Sports Medicine (2011)

Background In taekwondo (TKD), concussion incidence is four times greater than in American football. Biomechanical investigations on concussion in TKD is sparse. Objective To examine differences in TKD kicks on resultant head linear acceleration (RLA), head injury criterion (HIC15) and peak head velocity (HVEL). Design Between-groups. Setting Biomechanics laboratory. Participants 12 elite male TKD athletes (22.5+3.5 years, 176.9+7.3 cm, 70.9+8.6 kg). Interventions Five head kicks (round kick (RK), front leg axe kick, clench-axe kick (CA), jump spin back kick, jump spin hook kick (JH)) were randomly performed five times each. A Hybrid II Crash Dummy head (H2D) was instrumented with a tri-axial accelerometer (PCB Piezotronics-356A66) mounted inside the H2D head. The H2D was fixed to a height adjustable frame and fitted with a protective TKD helmet. Acceleration data were captured using Qualisys Track Manager (Gothenburg, Sweden) and processed in accordance with SAE J211-1. Main outcome measurements RLA, HIC and HVEL. Results The RK (130.11±51.67 g) produced a higher RLA than the CA (54.95±20.08 g, p&lt;0.001, d=1.84) and a higher HIC15 than the JH (672.74±540.89 vs 300.19±144.35, p&lt;0.001, ES=0.97). The range of the RLA by the RK was 60.50–217.33 g, while the CA was 26.34–99.02 g. The HIC15 range for the RK was 128.40–1608.70 and the JH, 63.90–573.00. There was no difference in HVEL of the RK (4.73±1.67 m/s, range: 3.36–9.52 m/s) and that of the JH (4.43±0.78 m/s, range: 3.00–5.54 m/s) (p=0.977, ES&lt;0.01). Conclusion Our investigations are the first to identify the high-magnitude head impacts in TKD. A previous report suggests an HIC15 concussion threshold of &gt;200. The RK is of concern because it is the most common technique and most common cause of concussion in TKD and has a high RLA and HIC15. Prevention of concussion in TKD should focus on employing qualified medical personnel, injury monitoring, and safer equipment.
COVID-19 Vaccines Safe, Effective in Rheumatic Diseases
Authors: Bridget M. Kuehn
Journal: JAMA (2022)

Vaccination against SARS-CoV-2 provides people with inflammatory or noninflammatory rheumatic and musculoskeletal disease similar levels of protection with a similar adverse event profile as the general public, according to data from a registry of 5121 patients from 30 countries.
ST. BARTHOLOMEW'S HOSPITAL
Authors: S. Gee, J. Langton, D. Duckworth, H. Cripps, T. L. Brunton, W. B. Clarke, N. Moore, A. Bowlby, S. West, C. B. Lockwood, J. A. Ormerod, D. Power, W. P. Herringham, H. J. Waring, H. H. Tooth, W. M. Eccles, A. E. Garrod, R. C. Bailey, J. Calvert, W. H. H. Jessop, F. H. Champneys, T. H. Spicer, W. S. A. Griffith, A. E. Cumberbatch
Journal: BMJ (1903)