tbuckley/cabot-search huggingface dataset:
SOME FACTS ABOUT DIGESTIVE FERMENTS.
Authors: TORALD SOLLMANN
Journal: JAMA (1907)

<h3>OTHER INCOMPATIBILITIES IN LIQUID DIGESTANTS.</h3> The compound digestive liquids do not constitute the only incompatibility in the manufacture or prescription of digestive ferments, although they are probably the most glaring example. We must again recall that ferments are peculiarly unstable bodies; indeed, there are few substances so sensitive to reagents, so liable to injury, as the ferments, especially when they are dissolved. Acids and alkalies, salts, metals, alkaloids, tannins, antiseptics, chloroform, ether and alcohol—all these interfere more or less with the action of ferments and injure their activity. Alcohol is especially important, since it is a conspicuous constituent of the digestive "wines" and elixirs, particularly those of pepsin. <h3>THE EFFECT OF ALCOHOL ON FERMENTS.</h3> A short contact with alcohol does not appear to be injurious to most ferments, since one of the ordinary methods of purifying the crude ferments consists in their precipitation by alcohol. Prolonged contact with alcohol, however,
Age-dependent increase in vascular smooth muscle cell proliferation: Role of mitogen-activated protein kinases Giuseppa Gennaro, Sylvain Meloche, Edith Giasson, Fran�ois Gauthier, Catherine M�nard, Sophie Elise Michaud, Alain Rivard. Centre Hospitalier de l'Universit� de Montr�al, Montr�al, PQ, Canada
Journal: Journal of the American College of Cardiology (2001)
Prenatal Exposure to Antipsychotics−Handle With Caution
Authors: Sunn Hoah Kelvin Yap
Journal: JAMA Internal Medicine (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Echinococcosis of the thyroid gland. Report of two cases
Authors: G. D. Skalkeas
Journal: JAMA (1967)

ALTHOUGH echinococcosis in general continues to be widely spread in several countries, its location in organs other than the liver and the lungs is unusual, producing occasionally difficult diagnostic problems.<sup>1</sup> At the First Surgical Clinic of Athens (Greece) University, during the period extending from 1955 through 1966, 344 patients with echinococcosis were hospitalized. In 176 of them the cysts were located in the liver, in 122 in the lungs, and in the remaining 46 in various organs (spleen, vertebral column, pericardium, etc).<sup>2</sup> Hydatid cysts of the thyroid gland represent an extremely unusual location of the parasite even in countries where the disease is endemic. Up to 1950 only 96 cases had been reported in the international literature. Greek literature, one of the richest in the world on this subject, comprises 14 cases besides those presented here. <h3>Report of Cases</h3><h3>Case 1.—</h3> One and one half months prior to
Another Anniversary
Authors: Hugh H. Hussey
Journal: JAMA (1976)

In 1900 as the 19th century ended, at what was known as the General Meeting of the American Medical Association in Atlantic City, NJ, the following two resolutions were presented without preamble: <i>Resolved</i>, That a committee be appointed by the Association on the organization of the profession throughout the United States to cooperate with the Committee on National Legislation; this committee to consist of one member from each state and territory represented in the Association. <i>Resolved</i>, That a committee of three be appointed by the President to prepare plans in detail for such committee on organization; to enter into correspondence with officers of the various state societies, and to take such action in the premises as it may think advisable, and that the Trustees be requested to appropriate a sum not exceeding $150 for the necessary expenses of the committee. As a consequence, two special committees came into being, known
Cardiac enzyme elevations after coronary artery bypass grafting associated with increased risk of death: Results from PARAGON-B Kenneth W. Mahaffey, Matthew T. Roe, Rodney Sparapani, Christopher B. Dyke, John H. Alexander, Lisa G. Berdan, Christopher B. Granger, Magnus Ohman, Robert M. Califf, Eric J. Topol, Robert A. Harrington. Duke Clinical Research Institute, Durham, NC
Journal: Journal of the American College of Cardiology (2001)
CORRELATION BETWEEN LEUKOCYTE TELOMERE LENGTH AND DRUG ELUTING STENT STRUT COVERAGE BY OPTICAL COHERENCE TOMOGRAPHY
Authors: Ehrin J. Armstrong, Lei Xing, Jianzhong Zhang, Yanhua Zhang, Ramin Farzaneh&ndash;Far, Robert Yeh, Kendrick Shunk, Bo Yu, Ik-Kyung Jang
Journal: Journal of the American College of Cardiology (2012)
AMA—Burroughs Wellcome Co 1991 Awards Available
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The lung health study. Disappointment and triumph
Authors: N. J. Gross
Journal: JAMA (1994)

Chronic obstructive pulmonary disease (COPD) is a major and growing health problem throughout the world. In the United States, close to 13 million people were recognized to have the condition in 1986,<sup>1</sup>but even this staggering number is probably an underestimate.<sup>2</sup>Its annual cost was more than $12 billion in direct and indirect medical expenses in 1990. It is now the fourth leading cause of death in this country, with a mortality of more than 90 000 in 1991.<sup>3</sup>These figures do not reveal an equally vital statistic, the great physical limitation and suffering of many of these patients in the last years of their lives. The principal etiologic factor, and by far the most potent one, cigarette smoking, has been known for decades. Moreover, the classic studies of Fletcher et al in the United Kingdom<sup>4</sup>and the studies of many others See also p 1497.
Book Listings
Journal: Annals of Internal Medicine (2000)

Book Listings7 November 2000Book ListingsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-9-200011070-00002 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail CardiologyCoronary Circulation and Myocardial IschemiaMR Pinsky, A Artigas, and J Dhainaut, eds. 193 pages. New York: Springer-Verlag; 2000. $109.00. ISBN 3540625844. Order phone 800-777-4643.Dates in CardiologyH Lee, ed. 129 pages. New York: Parthenon; 2000. $29.00. ISBN 1850704988. Order phone 800-735-4744.Drugs, Enzymes and Receptors of the Renin-Angiotensin System: Celebrating a Century of DiscoveryA Husain and RM Graham, eds. 399 pages. Newark, NJ: Gordon and Breach/Harwood Academic; 2000. $148.00. ISBN 9058230384. Order phone 800-545-8398.Epidemiology of HypertensionCJ Bulpitt, ed. 706 pages. New York: Elsevier Science; 2000. $275.00. ISBN 044482779X. Order phone 212-989-5800.Jesse E. Edwards' Synopsis of Congenital Heart ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 7 November 2000Volume 133, Issue 9Page: B1KeywordsInterleukins ePublished: 7 November 2000 Issue Published: 7 November 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Omission of an Author’s Second Affiliation From the Author Affiliations
Authors: Elliott Norrish, Juan Kaski
Journal: JAMA Cardiology (2020)

Alexander R. van Rosendael, MD; Jagat Narula, MD, PhD; Fay Y. Lin, MD; Inge J. van den Hoogen, MD; Umberto Gianni, MD; Omar Al Hussein Alawamlh, MD; Patricia C. Dunham, BS; Jessica M. Peña, MD; Sang-Eun Lee, MD, PhD; Daniele Andreini, MD, PhD; Filippo Cademartiri, MD, PhD; Kavitha Chinnaiyan, MD; Benjamin J. W. Chow, MD; Edoardo Conte, MD; Ricardo C. Cury, MD; Gudrun Feuchtner, MD; Martin Hadamitzky, MD; Yong-Jin Kim, MD; Jonathon Leipsic, MD; Erica Maffei, MD; Hugo Marques, MD, PhD; Pedro de Araújo Gonçalves, MD, PhD; Fabian Plank, MD; Gianluca Pontone, MD, PhD; Gilbert L. Raff, MD; Todd C. Villines, MD; Harald G. Weirich, MD; Subhi J. Al’Aref, MD; Lohendran Baskaran, MD; Iksung Cho, MD; Ibrahim Danad, MD; Donghee Han, MD; Ran Heo, MD; Ji Hyun Lee, MD; Asim Rivzi, MD; Wijnand J. Stuijfzand, MD; Heidi Gransar, MSc; Yao Lu, MSc; Ji Min Sung, PhD; Hyung-Bok Park, MD; Habib Samady, MD; Peter H. Stone, MD; Renu Virmani, MD; Matthew J. Budoff, MD; Daniel S. Berman, MD; Hyuk-Jae Chang, MD, PhD; Jeroen J. Bax, MD, PhD; James K. Min, MD; Leslee J. Shaw, PhD
Predictors of outcome for prosthetic valve thrombolysis: Results of the international PRO-TEE registry (prosthetic valve thrombolysis: Role of trans-esophageal echocardiography) Ann T. Tong, Raymond Roudaut, Mehmet Ozkan, Alex Sagie, Yaron Shapira, Sarah Shimoni, Maie S. A. Shahid, Sergio C. Pontes, Jr., Francesc Carreras, Steve E. Girard, Fletcher A. Miller, Jr., Samir Arnaout, Raymond F. Stainback, J. Kay Dunn, William A. Zoghbi. on behalf of the PRO-TEE Investigators, Baylor College of …
Journal: Journal of the American College of Cardiology (2001)
Covid-19 Vaccine Effectiveness in New York State
Authors: Eli S Rosenberg, Vajeera Dorabawila, Delia Easton, Ursula E Bauer, Jessica Kumar, Rebecca Hoen, Dina Hoefer, Meng Wu, Emily Lutterloh, Mary Beth Conroy, Danielle Greene, Howard A Zucker
Journal: New England Journal of Medicine (2021)

Population-based data from the United States on the effectiveness of the three coronavirus disease 2019 (Covid-19) vaccines currently authorized by the Food and Drug Administration are limited. Whether declines in effectiveness are due to waning immunity, the B.1.617.2 (delta) variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), or other causes is unknown.We used data for 8,690,825 adults in New York State to assess the effectiveness of the BNT162b2, mRNA-1273, and Ad26.COV2.S vaccines against laboratory-confirmed Covid-19 and hospitalization with Covid-19 (i.e., Covid-19 diagnosed at or after admission). We compared cohorts defined according to vaccine product received, age, and month of full vaccination with age-specific unvaccinated cohorts by linking statewide testing, hospital, and vaccine registry databases. We assessed vaccine effectiveness against Covid-19 from May 1 through September 3, 2021, and against hospitalization with Covid-19 from May 1 through August 31, 2021.There were 150,865 cases of Covid-19 and 14,477 hospitalizations with Covid-19. During the week of May 1, 2021, when the delta variant made up 1.8% of the circulating variants, the median vaccine effectiveness against Covid-19 was 91.3% (range, 84.1 to 97.0) for BNT162b2, 96.9% (range, 93.7 to 98.0) for mRNA-1273, and 86.6% (range, 77.8 to 89.7) for Ad26.COV2.S. Subsequently, effectiveness declined contemporaneously in all cohorts, from a median of 93.4% (range, 77.8 to 98.0) during the week of May 1 to a nadir of 73.5% (range, 13.8 to 90.0) around July 10, when the prevalence of the delta variant was 85.3%. By the week of August 28, when the prevalence of the delta variant was 99.6%, the effectiveness was 74.2% (range, 63.4 to 86.8). Effectiveness against hospitalization with Covid-19 among adults 18 to 64 years of age remained almost exclusively greater than 86%, with no apparent time trend. Effectiveness declined from May through August among persons 65 years of age or older who had received BNT162b2 (from 94.8 to 88.6%) or mRNA-1273 (from 97.1 to 93.7%). The effectiveness of Ad26.COV2.S was lower than that of the other vaccines, with no trend observed over time (range, 80.0 to 90.6%).The effectiveness of the three vaccines against Covid-19 declined after the delta variant became predominant. The effectiveness against hospitalization remained high, with modest declines limited to BNT162b2 and mRNA-1273 recipients 65 years of age or older.
Toxic and Carcinogenic Effects of Stilbestrol in Strain C3H Male Mice
Authors: Michael B. Shimkin, Hugh G. Grady
Journal: JNCI Journal of the National Cancer Institute (1941)

Toxic and Carcinogenic Effects of Stilbestrol in Strain C3H Male Mice Michael B. Shimkin, Michael B. Shimkin assistant surgeon Search for other works by this author on: Oxford Academic PubMed Google Scholar Hugh G. Grady Hugh G. Grady acting assistant surgeon National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 2, Issue 1, August 1941, Pages 55–60, https://doi.org/10.1093/jnci/2.1.55 Published: 01 August 1941
Hepatic stellate cell activation and senescence induced by intrahepatic microbiota disturbances drive progression of liver cirrhosis toward hepatocellular carcinoma
Authors: Boyuan Liu, Zewei Zhou, Yu Jin, Jinying Lu, Dongju Feng, Rui Peng, Hua Sun, Xiaoxin Mu, Changxian Li, Yun Chen
Journal: Journal for ImmunoTherapy of Cancer (2022)

Background The significance of the relationship between the microbiota and diseases is increasingly being recognized. However, the characterization of tumor microbiome and their precise molecular mechanisms through which microbiota promotes hepatocellular carcinoma (HCC) development are still unclear. Methods The intrahepatic microbiota was investigated from tumor, normal adjacent tissues in 46 patients with HCC and normal hepatic tissues in 33 patients with hemangioma by 16S rRNA gene sequencing. Taxonomic composition differences in patients were evaluated using Linear discriminant analysis Effect Size (LefSe) and Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) to predict microbial functional pathways. Associations between the most relevant taxa and clinical characteristics of HCC patients were analyzed by Spearman rank correlations. The effects of microbe on hepatic stellate cells (HSCs) activation and HCC progression were examined. Results We observed intrahepatic microbiota disturbances by reduced microbial diversity in HCC. The tumor microbiota of the HCC patients with cirrhosis showed higher abundance of Stenotrophomonas maltophilia (S. maltophilia) . S. maltophilia provoked senescence-associated secretory phenotype (SASP) in HSCs by activating TLR-4-mediated NF-κB signaling pathway, which in turn induced NLRP3 inﬂammasome complex formation and secreted various inflammatory factors in the liver, thus facilitating HCC progression in mice. Moreover, signs of SASP were also observed in the HSCs in the area of HCC with higher S. maltophilia enrichment arising in patients with cirrhosis. Conclusions Our analysis of the hepatic microbiota revealed for the first time that patients with HCC exhibited a dysbiotic microbial community with higher S. maltophilia abundance, which induced the expression SASP factors of HSCs and cirrhosis in the liver, concurring in the process of hepatocarcinogenesis.
Treatment with folic acid and cobalamin improves coronary endothelial function in hyperhomocysteinemic patients with symptomatic coronary artery disease Frank F. Willems, Wim RM Aengevaeren, Godfried HJ Boers, Henk J Blom, Freek WA Verheugt. university medical center, nijmegen, The Netherlands, Rijnstate hospital, arnhem, The Netherlands
Journal: Journal of the American College of Cardiology (2001)
Medical and Surgical Report of the Presbyterian Hospital in the city of New York, Volume iii, January, 1898.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnosis of COVID‐19 using skin rashes
Journal: British Journal of Dermatology (2021)

Several studies have observed that patients hospitalized with COVID-19 experienced unusual skin rashes, such as urticaria ('nettle rash'), chickenpox-type rash, and reddish and purplish bumps on the fingers or toes.Using data from about 336,000 UK users of the COVID Symptom Study app, we observed that 8.8% of people reporting a positive SARS-CoV-2 swab test had experienced a skin rash, compared with 5.4% of those with a negative test result.Next, we analysed data collected using an independent online survey in nearly 12,000 people with skin rashes and a suspected or confirmed SARS-CoV-2 infection.We observed that 17% of respondents testing positive reported a rash as the first symptom of the disease, while for 21% of them this was their only symptom.Taking these observations together, we advise that skin rashes should be considered when diagnosing COVID-19 infection.To increase awareness regarding these symptoms we have created, in collaboration with the British Association of Dermatologists, an online catalogue of images of the most common skin manifestations of COVID-19, available at https://covidskinsigns.com.
&lt;TITLE&gt;Screening and Prevention of Sexually Transmitted Diseases&lt;/TITLE&gt;
Journal: JAMA (2001)

The JAMA Patient Page is a public service of JAMA.The information and recommendations appearing on this page are appropriate in most instances, but they are not a substitute for medical diagnosis.For specific information concerning your personal medical condition, JAMA and the AMA suggest that you consult your physician.This page may be reproduced noncommercially by physicians and other health care professionals to share with patients.Any other reproduction is subject to AMA approval.To purchase bulk reprints, call 718/946-7424. Most people who have an infection usually will experience at least one or two noticeable symptoms.However, many people who have a sexually transmitted infection caused by chlamydia might not have symptoms and might not know they are infected.This is why it is important to get tested or "screened" if you are at risk for coming in contact with someone who is infected.Chlamydia is a sexually transmitted disease caused by infection with a type of bacteria called Chlamydia trachomatis.An article in the January 3, 2001, issue of JAMA discusses the association between infection with certain strains or serotypes of Chlamydia trachomatis and a higher likelihood of contracting cervical squamous cell carcinoma (cancer of the cervix-part of a woman' s reproductive tract).
Evaluation of post-discharge deterioration following major gastrointestinal cancer surgery.
Authors: Rachel H. Joung, Ruojia D. Li, Jeanette W. Chung, David J. Bentrem, Anthony D. Yang, Karl Y. Bilimoria, Ryan P. Merkow
Journal: Journal of Clinical Oncology (2022)

667 Background: Clinical deterioration, defined as end-organ dysfunction following surgery, is a devastating, yet potentially preventable set of complications, usually occurring after an inciting event. The extent to which deterioration occurs post-discharge after major gastrointestinal cancer surgeries is unknown. Our objectives were to (1) evaluate the incidence of post-discharge deterioration (PDD), (2) characterize the events surrounding PDD, and (3) identify factors associated with PDD. Methods: Patients who underwent gastrointestinal resection for cancer were identified from the American College of Surgeons National Surgical Quality Improvement Program Participant Use Data File (2016-2019). Clinical deterioration was measured as a composite event consisting of respiratory failure, acute renal failure, cardiac arrest, or septic shock. Factors associated with PDD were evaluated using multivariable logistic regression. Results: Of 121,458 patients, 3,947 (3.3%) experienced clinical deterioration, with 19.1% occurring post-discharge. The median time to PDD from discharge was 8 days (IQR 4-13 days). Among patients who developed PDD, 58.9% had a previously diagnosed post-discharge complication, most commonly surgical site infection (38.2%), pneumonia (9.9%), and venous thromboembolism (5.4%). PDD was associated with older age, male sex, medical comorbidities, dependent functional status, longer operative time, transfusion, and discharge to a facility (all p &lt; 0.05). Patients who underwent esophagectomy (OR 2.08 [95%CI, 1.39-3.10]) or pancreatectomy (OR 1.36 [95%CI, 1.07-1.74]) had significantly higher odds of developing PDD compared to patients who underwent colectomy. Conclusions: Post-discharge deterioration after major cancer surgeries commonly occurred after other potentially treatable post-discharge complications. Efforts should focus on improving post-discharge monitoring and timely and effective management of post-discharge complications to arrest their progression to post-discharge deterioration and mortality.