tbuckley/cabot-search huggingface dataset:
Nonuniform epicardial activation and repolarization properties of in vivo canine pulmonary conus.
Authors: M JBurgess, B MSteinhaus, K WSpitzer, P RErshler
Journal: Circulation Research (1988)

The relation between nonuniform epicardial activation and ventricular repolarization properties was studied in 14 pentobarbital anesthetized dogs and with a computer model. In 11 dogs, isochrone maps of epicardial activation sequence were constructed from electrograms recorded from the pulmonary conus with 64 electrodes on an 8 X 8 grid with 2-mm electrode separation. The heart was paced from multiple sites on the periphery of the array. Uniformity of epicardial activation was estimated from activation times at test sites and their eight neighboring sites. Acceleration shortened and deceleration prolonged refractory periods. The locations of acceleration and deceleration sites of activation differed during drives from various sites, and differences in uniformity of activation during pairs of drives were correlated to differences in refractory periods (r = 0.76, range 0.59-0.93). In three additional experiments, transmural activation sequence maps were constructed from electrograms recorded from needle-mou...
Predictors Of Failure Of Papilla Cannulation During Ercp For Common Bile Duct Stones
Authors: A Nakhli, M Sabbah, N Bellil, D Trad, A Ouakaa, H Elloumi, N Bibani, D Gargouri
Journal: Endoscopy (2021)

Aims Duodenal papilla cannulation is the first step in endoscopic retrograde cholangiopancreatography (ERCP). When cannulation of the papilla is difficult, it increases the risk of post-ERCP complications. In this case, the use of second-line endoscopic techniques should be considered (precut, infundibulotomy). The objective of this study was to determine the predictors of failure of papilla cannulation during ERCP for common bile duct (CBD) stones.
Association of levels of lipoprotein Lp(a), plasma lipids, and other lipoproteins with coronary artery disease documented by angiography.
Authors: G HDahlen, J RGuyton, MAttar, J AFarmer, J AKautz, A MGotto
Journal: Circulation (1986)

In a study of 307 white patients who underwent coronary angiography, the relationship of coronary artery disease (CAD) to plasma levels of lipoprotein Lp(a) and other lipid-lipoprotein variables was examined. Lp(a) resembles low-density lipoprotein (LDL) in several ways, but can be distinguished and quantified by electroimmunoassay. CAD was rated as present or absent and was also represented by a quantitative lesion score derived from estimates of stenosis in four major coronary vessels. Coronary lesion scores significantly correlated with Lp(a), total cholesterol, triglycerides, LDL cholesterol, and high-density lipoprotein (HDL) cholesterol levels by univariate statistical analysis. By multivariate analysis levels of Lp(a) were associated significantly and independently with the presence of CAD (p less than .02), and tended to correlate with lesion scores (p = .06). Among subgroups Lp(a) level was associated with CAD in women of all ages and in men 55 years old or younger. An apparent threshold for coro...
Dual echocardiographic determination of atrial contraction sequence in atrial flutter and other related atrial arrhythmias.
Authors: JFujii, J RFoster, P GMills, SMoos, ECraige
Journal: Circulation (1978)

We have applied the new technique of dual echocardiography to determine the sequence of atrial contraction as reflected in the simultaneously recorded movements of the tricuspid and mitral valves. The study group included 29 normal subjects and 23 patients with either atrial flutter, coarse atrial fibrillation or atrial tachycardia with block. In normal individuals, right atrial contraction preceded left atrial contraction, with an average interatrial contraction time of 17 +/- 8 msec. In contrast, the atrial contraction sequence was reversed in atrial flutter, with left preceding right atrial contraction and a prolonged interatrial contraction time of 82 +/- 20 msec. In two patients with atrial tachycardia with block, atrial contraction was either simultaneous or left preceded right atrial contraction by a brief interval. The sequence of atrial excitation, as determined by electrode catheter recordings from the right and left atria in one patient with atrial flutter and one patient with normal sinus rhyt...
How young children integrate information sources to infer the meaning of words
Authors: Manuel Bohn, Michael Henry Tessler, Megan Merrick, Michael C. Frank
Journal: Nature Human Behaviour (2021)

Abstract Before formal education begins, children typically acquire a vocabulary of thousands of words. This learning process requires the use of many different information sources in their social environment, including their current state of knowledge and the context in which they hear words used. How is this information integrated? We specify a developmental model according to which children consider information sources in an age-specific way and integrate them via Bayesian inference. This model accurately predicted 2–5-year-old children’s word learning across a range of experimental conditions in which they had to integrate three information sources. Model comparison suggests that the central locus of development is an increased sensitivity to individual information sources, rather than changes in integration ability. This work presents a developmental theory of information integration during language learning and illustrates how formal models can be used to make a quantitative test of the predictive and explanatory power of competing theories.
Poem as a Treatment Option For Achalasia In Patients 65 Years of Age and Older
Authors: I Kanischev, I Nedoluzhko, K Shishin, N Kurushkina, L Shumkina
Journal: Endoscopy (2021)

Aims POEM is an effective method of treatment in patients with achalasia. The efficacy of that endoscopic intervention is comparable to Heller’s operation. Shorter operation time and length of hospital stay, as well as lower complication rate, are among the advantages of the peroral procedure. However, the usage of this operation in patients over 65 years with comorbidities is doubtful.
Determination of anaerobic threshold for assessment of functional state in patients with chronic heart failure.
Authors: NMatsumura, HNishijima, SKojima, FHashimoto, MMinami, HYasuda
Journal: Circulation (1983)

The use of anaerobic threshold in assessment of aerobic capacity was evaluated in 34 normal subjects and 47 patients with various kinds of chronic heart disease. Anaerobic threshold was determined as the oxygen consumption (VO2) at which a linear relationship between pulmonary ventilation (VE) and VO2 was lost during progressive treadmill exercise. Anaerobic threshold determined in this manner was validated with that determined by blood lactate measurements in eight normal subjects and nine cardiac patients (r = .962, p less than .001). Thereafter, anaerobic threshold was determined only by respiratory measurements. In symptom-limited, maximal exercise, anaerobic threshold was reached well before maximal effort and corresponded to 70% of maximal VO2 both in normal subjects and cardiac patients. Anaerobic threshold decreased as age progressed in normal subjects (r = - .70, p less than .001). Anaerobic threshold in cardiac patients was lower than that in the normal subjects and decreased progressively as Ne...
EUS-Guided Esophageal Fiducial Biomarker Placement For Stereotactic Body Radiation Therapy In A Superficial Cancer
Authors: JG Velasquez-Rodriguez, A Boladeras-Inglada, A Garcia-Sumalla, S Maisterra, M Galan, JB Gornals
Journal: Endoscopy (2021)

A 59-year-old man diagnosed of superficial esophageal adenocarcinoma and proposed for curative stereotactic body radiotherapy (SBRT).
Vascular E-Selectin Mediates Chemo-Resistance in Acute Myeloid Leukemia Initiating Cells Via Canonical Receptors PSGL-1 (CD162) and Hcell (CD44) and AKT Signaling
Authors: Ingrid G Winkler, Johanna M Erbani, Valerie Barbier, Julie M Davies, Joshua Tay, Corrine E Fiveash, Jessica Lowe, Michael Tallack, John L Magnani, Jean-Pierre Levesque
Journal: Blood (2017)
Murine liver allograft transplantation: Tolerance and donor cell chimerism
Authors: S Wian
Journal: Hepatology (1994)

Nonarterialized orthotopic liver transplantation with no immunosuppression was performed in 13 mouse-strain combinations.Two strain combinations with major histocompatibility complex class I and class II and minor histocompatibility complex disparity had 20% and 33% survival of more than 100 days, but the other 11 combinations, including four that were fully allogeneic and all with only class I, class II or minor disparities, yielded 45% to 100% survival of more than 100 days.Longliving recipients permanently accepted donor-strain heterotopic hearts transplanted on the same day or donor-strain skin 3 mo after liver transplantation, in spite of detectable antidonor in vitro activity with mixed lymphocyte reaction and cell-mediated lymphocytotoxicity testing (split tolerance).In further donor-specific experiments, liver grafts were not rejected by presensitized major histocompatibility complex class I-disparate recipients and they protected donor-strain skin grafts from second set (or any) rejection.Less frequently, liver transplantation rescued rejecting skin grafts placed 1 wk earlier in major histocompatibility complex class I, class II and minor histocompatibility complex, class II or minor histocompatibility complex-disparate strain combinations.Donor-derived leukocyte migration to the central lymphoid organs occurred within 1 to 2 hr after liver transplantation in all animals examined, persisted in the surviving animals until they were killed (> 375 days), and was demonstrated with double-immunolabeling to be multilineage.The relation of these findings to so-called hepatic tolerogenicity and to tolerance in general is discussed.We have proposed that a reciprocal migration of leukocytes of bone marrow origin between graft and host, with subsequent chimerism in both, is the first step toward donor-specific nonreactivity (tolerance) that may or may not require immunosuppression (1-7).According to this concept, the variable tolerogenicity and ease of "acceptance" of different organs merely reflect the comparative content of these multilineage leukocytes, of which the antigenpresenting dendritic cell defined as a distinct lineage by Steinman and Cohn (8,9) is the most critical (1-7).In our study of liver transplantation in mice, we have examined the effect of major histocompatibility complex (MHC) on hepatic tolerogenicity and chimerism, with further attention to the lineages and traffic of the donor leukocytes.
The Impact of Electrical Calf Muscle Stimulation on the Residual Venous Obstruction and DVT Recurrence after Cessation of Standard Anticoagulation
Authors: Kirill Lobastov, Vladimir Ryzhkin, Athena Vorontsova, Iliya Schastlivtsev, Victor Barinov, Leonid Laberko, Grigory Rodoman
Journal: Blood (2017)
Reply: Excess Risk of Cancer from Computed Tomography Scan Is Small but Not So Low as to Be Incalculable
Authors: Tim Rosenow, Merel C. J. Oudraad, Conor P. Murray, Lidija Turkovic, Wieying Kuo, Marleen de Bruijne, Sarath C. Ranganathan, Harm A. W. M. Tiddens, Stephen M. Stick
Journal: American Journal of Respiratory and Critical Care Medicine (2015)
Mechanisms and risk factors for proarrhythmia with type Ia compared with Ic antiarrhythmic drug therapy.
Authors: J HLevine, JMorganroth, A HKadish
Journal: Circulation (1989)

Proarrhythmia defined as the exacerbation of existing arrhythmias or the genesis of new arrhythmias de novo may result from any antiarrhythmic agent. The two general clinical syndromes of sustained arrhythmias that result appear to have distinct clinical properties that are consistent with the proposed basic mechanisms of arrhythmogenesis. Torsades de points occurs most commonly in association with administration of type Ia antiarrhythmic agents and has characteristics most consistent with triggered activity mediated by early after depolarization. Conversely, incessant, sustained, monomorphic, wide complex ventricular tachycardia occurs most commonly in association with type Ic antiarrhythmic agents and has characteristics most consistent with incessant reentry. These general subdivisions are probably oversimplified, and in fact, much overlap likely exists. In addition, these proposed mechanisms may not apply to other forms of proarrhythmia such as an increased frequency of isolated ventricular premature ...
Choledocian Empierrements: What Are The Factors Of Failure Of Stone Extraction?
Authors: MK Temani, M Mahmoudi, S Laabidi, M Medhioub, A Khsiba, L Hamzaoui, M Azzouz
Journal: Endoscopy (2021)

Aims To assess the rate of stone extraction failure during choledocian empierrements (CE) and the associated factors.
Clinical and echocardiographic features of pulmonary valve endocarditis.
Authors: KNakamura, GSatomi, TSakai, MAndo, AHashimoto, HKoyanagi, KHirosawa, ATakao
Journal: Circulation (1983)

We studied the clinical and echocardiographic features of eight patients with infective pulmonary valve endocarditis. In two patients, the vegetation was limited to the pulmonary valve; in the six other patients, infective lesions were also present on the mitral or aortic valves. None of the patients were addicted to narcotics. Seven of the eight patients had underlying congenital heart disease. In six patients the organism responsible for the infective endocarditis was Streptococcus viridans. Two-dimensional echocardiography performed using a wide-angle sector scanner was more useful than M-mode echocardiography for evaluating patients with pulmonary valve endocarditis.
A new, simplified and accurate method for determining ejection fraction with two-dimensional echocardiography.
Authors: M AQuinones, A DWaggoner, L AReduto, J GNelson, J BYoung, W LWinters, L GRibeiro, R RMiller
Journal: Circulation (1981)

A new method to determine left ventricular (LV) ejection fraction (EF) with wide-angle, two-dimensional echocardiography (2-D echo) has been developed using the parasternal long-axis, apical four-chamber and apical long-axis views. End-diastolic and end-systolic measurements of LV short axes at the base and mid-LV cavity in the parasternal long-axis view and at the upper, middle and lower thirds of the cavity in the apical views are made, from which an averaged minor axis at end-diastolic and at end-systole is calculated. Fractional shortening of the LV long axis (delta L) is estimated from apical contraction. Satisfactory 2-D echoes were obtained in 55 of 58 nonselected patients (all three views in 32 patients, two views in 22 and one view in one); 42 of 55 patients had coronary artery disease. EF by 2-D echo was compared with EF by gated cardiac blood pool imaging in all patients (r = 0.927, SEE = 6.7%) and to EF by single-plane cineangiography (angio) in 35 of 55 patients (r = 0.913, SEE = 7.4%). LV dy...
Quantifying the Costs of Care Among Patients With High-Risk Non–Muscle-Invasive Bladder Cancer Treated in the Veterans Health Administration
Authors: Alejandro Sanchez, Neeraj Agarwal
Journal: JAMA Network Open (2021)

Stephen B. Williams, MD, MS; Lauren E. Howard, MS; Meagan L. Foster, BS; Zachary Klaassen, MD, MSc; Jan Sieluk, PhD; Amanda M. De Hoedt, MS; Stephen J. Freedland, MD
Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 From the Mother to the Infant
Authors: Midori Hijikata, Aya Okahashi, Ichiro Morioka
Journal: JAMA Pediatrics (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Effects of activation on distribution of Ca2+ in single arterial smooth muscle cells. Determination with fura-2 digital imaging microscopy.
Authors: W FGoldman, W GWier, M PBlaustein
Journal: Circulation Research (1989)

A rise in cytosolic free Ca2+ is the immediate trigger for contraction in mammalian vascular smooth muscle. We used the fluorescent calcium indicator fura-2 and digital imaging microscopy to study the spatial distribution of intracellular Ca2+ in arterial myocytes and the changes elicited by activation with norepinephrine (NE). Viable arterial myocytes were obtained from bovine tail arteries by enzymatic digestion. In modified Krebs' solution containing 1.8 mM Ca2+, these myocytes were relaxed and spindle-shaped. The cells contracted rapidly when exposed to NE or high-K+ solution ejected from a micropipette; they relaxed slowly when the activator was washed away. NE evoked a rise in Ca2+ concentration ([Ca2+]) in the cells within 100 msec, at a time when the cells had not yet begun to contract. Maximal [Ca2+] levels were attained within 600 msec, at which time the cells were substantially contracted. Digital analysis of images of cellular fura-2 fluorescence revealed that the intracellular [Ca2+] was rela...
Heart rate and arterial blood pressure during exercise in patients with angina pectoris. Effects of training and of nitroglycerin.
Authors: J PClausen, JTrap-Jensen
Journal: Circulation (1976)

In 29 patients with typical exertional angina pectoris, intra-arterial systolic blood pressure (SBP), heart rate (HR), and the rate-pressure product (RPP = HR X SBP X 10(-2) were continuously recorded during repeated bouts of leg or arm exercise. Development of chest pain was independent of the workload and occurred at a fairly constant value of RPP, of HR, and of SBP in each patient for a given type of exercise, but the pain threshold values for all three variables were consistently higher during arm exercise than during leg exercise. The reproducibility of the pain threshold values was assessed for leg exercise. The variation, based on individual coefficients of variation, ranged from 1.3% to 13% (group mean, about 6%). There was no significant difference between the SBP values obtained by the traditional, noninvasive cuff technique and the values during intra-arterial monitoring. In 25 patients a physical training program of an average of three months increased the maximal amount of work (watt X sec) p...
The impact of fraudulent research on the scientific literature. The Stephen E. Breuning case
Authors: E. Garfield
Journal: JAMA (1990)

The goal of this study was to determine the research impact of scientific fraud through citation analysis of 20 Breuning publications, using the 1980 to 1988<i>Science Citation Index and Social Sciences Citation Index</i>. These publications received 200 citations, of which 80 (40.0%) were self-citations by Breuning or his coauthors. Tracked over time, non—self-citations declined sharply in 1986 and later years, coinciding with disclosure of Breuning's fraud. The data indicated that, in this case, researchers effectively shunned work known to be or even suspected of being falsified. Unique citation contexts (101) were examined to see how citing authors used Breuning's work: 33 were negative (disagreed with findings/methods), 10 positive (agreed), and 58 neutral (no valuation). Also, 63 were inconsequential (no influence on the citing author's analysis/conclusion). Thirty-eight were material, but 21 of these led to negative conclusions. These data diminish the apparent impact of Breuning's work suggested by total citations alone. (<i>JAMA</i>. 1990;263:1424-1426)
Corticosteroids for Patients With Septic Shock
Authors: Steven M. Opal
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abnormalities of sodium handling and of cardiovascular adaptations during high salt diet in patients with mild heart failure.
Authors: MVolpe, CTritto, NDeLuca, SRubattu, M ARao, FLamenza, AMirante, IEnea, VRendina, A FMele
Journal: Circulation (1993)

BACKGROUNDSodium retention and hormonal activation are fundamental hallmarks in congestive heart failure. The present study was designed to assess the ability of patients with asymptomatic to mildly symptomatic heart failure and no signs or symptoms of congestion to excrete ingested sodium and to identify possible early abnormalities of hormonal and hemodynamic mechanisms related to sodium handling.METHODS AND RESULTSThe effects of a high salt diet (250 mEq/day for 6 days) on hemodynamics, salt-regulating hormones, and renal excretory response were investigated in a balanced study in 12 untreated patients with idiopathic or ischemic dilated cardiomyopathy and mild heart failure (NYHA class I-II, ejection fraction < 50%) (HF) and in 12 normal subjects, who had been previously maintained a 100 mEq/day NaCl diet. In normal subjects, high salt diet was associated with significant increases of echocardiographically measured left ventricular end-diastolic volume, ejection fraction, and stroke volume (all P < .0...
Evidence against the "early protection-delayed death" hypothesis of superoxide dismutase therapy in experimental myocardial infarction. Polyethylene glycol-superoxide dismutase plus catalase does not limit myocardial infarct size in dogs.
Authors: MTanaka, R CStoler, G PFitzHarris, R BJennings, K AReimer
Journal: Circulation Research (1990)

We previously found that superoxide dismutase (SOD) did not limit myocardial infarct size after 40 or 90 minutes of ischemia and 4 days of reperfusion in dogs. Because some other studies have shown limitation of infarct size after shorter periods of reperfusion, we postulated that our negative results might be due to late reperfusion injury mediated by superoxide anions produced after excretion of SOD. To test this early protection-delayed death hypothesis, we have examined whether SOD, conjugated to polyethylene glycol (PEG-SOD) to prolong its circulating half-life, limited myocardial infarct size. The circumflex artery was occluded for 90 minutes followed by 4 days of reperfusion. PEG-SOD (total dose, 10,000 units/kg) and catalase (55,000 units/kg) were given during the 30 minutes before reperfusion. Plasma SOD levels in the treated group were 330 +/- 20 units/ml at the onset of reperfusion and 140 +/- 10 units/ml on day 4 (circulating half-life, 75 +/- 5 hours) versus 5 +/- 1 units/ml in controls. Hi...