tbuckley/cabot-search huggingface dataset:
Calcium and Vitamin D Supplements and Fractures in Community-Dwelling Adults
Authors: Yangyang Wang, Zhijun Huang, Bin Yi
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Singlet oxygen-induced arrhythmias. Dose- and light-response studies for photoactivation of rose bengal in the rat heart.
Authors: YKusama, MBernier, D JHearse
Journal: Circulation (1989)

In a study of aerobically perfused rat hearts, the in situ photoactivation (530-590 nm) of rose bengal (a process that leads to the production of singlet oxygen and superoxide) has been shown to lead to the rapid development of electrocardiographic abnormalities and arrhythmias. With rose bengal concentrations of 1,000, 500, 250, 100, and 50 nmol/l (n = 6/group), photoactivation (3,600 lx) led to electrocardiographic changes (inversion of the T wave, Q-T prolongation, or both) after 3.8 +/- 0.9, 4.5 +/- 0.7, 11.8 +/- 2.1, 24.8 +/- 3.9, and 65.3 +/- 6.0 seconds), respectively; ventricular premature beats occurred in 100% of hearts after 0.5 +/- 0.2, 1.1 +/- 0.3, 2.2 +/- 0.7, 4.4 +/- 0.8, and 6.6 +/- 1.2 minutes, respectively. Ventricular tachycardia occurred in 83%, 83%, 83%, 67%, and 50% of hearts after 2.1 +/- 0.2, 2.1 +/- 0.4, 2.8 +/- 0.7, 5.7 +/- 2.0, and 11.2 +/- 1.9 minutes, respectively, and complete atrioventricular block in 100%, 100%, 100%, 100%, and 67% of hearts after 3.8 +/- 0.7, 6.5 +/- 1.0, ...
Role of renin in the pathogenesis of renal hypertension.
Authors: O PGulati, O ACarretero, N BOza, L AFernandez, ASchork
Journal: Circulation Research (1975)

To test the hypothesis that renin is circulating in pressor amounts in renal hypertension, two-kidney Goldblatt hypertension was produced in rats. After hypertension had been present for a variable period of time (4 to 21 days), the ischemic kidney was removed, and an infusion of rat renin was started immediately to replace the endogenous renin that the ischemic kidney had been releasing. Since the amount of renin released by the clipped kidney was not known, the amount infused was regulated by a feedback mechanism set to keep the mean blood pressure at the same level as before ipsilateral nephrectomy. Hypertension remission was therefore prevented by this procedure. The PRA at the end of the renin infusion was similar to that prior to the ipsilateral nephrectomy. This finding indicates that the levels of the PRA circulating in renal hypertension are within the pressor range, thus supporting the hypothesis that renin plays a role in the pathogenesis of the acute or semiacute phase of renal hypertension. H...
Cardiac causes of shock early after open heart surgery: etiologic classification by radionuclide ventriculography.
Authors: T MBateman, L SCzer, R MKass, M JRaymond, AChaux, J MMatloff, D SBerman, R JGray
Journal: Circulation (1985)

Early after open heart surgery, cardiac shock due to tamponade is easily misdiagnosed as ventricular dysfunction. The distinction is critical to successful therapy. We assessed the utility of 99mTc-red blood cell, gated equilibrium radionuclide ventriculography in 50 patients with early postoperative cardiac shock after historical, clinical, and invasive hemodynamic evaluation failed to identify either tamponade or ventricular dysfunction as the specific cause of their shock. The cause was established by radionuclide ventriculography in 45 of 50 patients and led to a change in therapy in 21 patients. A single cause was found in 35 patients: 13 had severe global dysfunction of the left ventricle (three patients), right ventricle (seven patients), or both ventricles (three patients); three had severe segmental left ventricular dysfunction; and 19 had an exaggerated region of photon deficiency (nine patients) or an abnormal and accumulating blood pool (10 patients) surrounding small hyperdynamic ventricles. ...
Effect of temperature on the rise in intracellular sodium caused by calcium depletion in ferret ventricular muscle and the mechanism of the alleviation of the calcium paradox by hypothermia.
Authors: M SSuleiman, R AChapman
Journal: Circulation Research (1990)

The effects of temperature over the range 37-10 degrees C on the responses of isolated ferret ventricular trabeculae to the depletion and repletion of bathing calcium has been investigated. Cooling is found to reduce the rate of rise of intracellular sodium activity (measured with an ion-sensitive microelectrode) induced by depletion of bathing divalent cations, without affecting the prolonged depolarization. The rate of rise of [Na]i (with the sodium pump inhibited) shows a dependence on temperature (energy of activation, 67 kJ.mol-1; Q10, 2.3-2.8) that increases with increasing temperature. This contrasts with previously published data for the sodium pump for which the temperature dependence falls with increasing temperature. These results offer an explanation for the alleviation of the calcium paradox caused by cooling during the period of calcium depletion, which is similar to other procedures that offer protection by limiting the rise in [Na]i by having effects on the L-type calcium channel.
Carpal Tunnel Syndrome
Authors: J. Patrick
Journal: BMJ (1965)

BEITOSH 1377 febrile convulsions are extremely rare in the newborn.What is meant by " febrile con- vulsions" ?Do we really know enough about the cause of the first seizure in any patient to be so precise about treatment ?Are we so advanced in understanding the mode of action of anticonvulsant drugs to use them at the time of the first seizure, whatever its cause might have been ?-Iam, etc.,
ヒト心房性ナトリウム利尿ペプチドは,ウサギのTorsades de Pointesを抑制する
Authors: Inaba Hideko, Hayami Noriyuki, Ajiki Kohsuke, Sugishita Yasuyuki, Kunishima Tomoyuki, Yamagishi Noboru, Yamagishi Satoshi, Murakawa Yuji
Journal: Circulation (2008)
A study of the human heart as a multiple dipole source. IV. Left ventricular hypertrophy in the presence of right bundle branch block.
Authors: J HHolt, A CBarnard, J OKramer
Journal: Circulation (1977)

This report concerns the task of electrocardiographic (ECG) diagnosis and quantitation of left ventricular hypertrophy (LVH) in patients with right bundle branch block (RBBB). In 36 patients with RBBB the left ventricular mass (LVM) of each patient was independently known from quantitative biplane angiography. Two ECG techniques, standard 12-lead ECG and multiple dipole electrocardiography (MDECG), were evaluated. In diagnosing LVH, the best performance of the several standard ECG criteria was sensitivity = 29%, specificity = 100%, and that of the MDECG was sensitivity = 94%, specificity = 96%. In quantitating LVH, the standard ECG gave a correlation with LVM of r = 46% and a standard error of estimate of 98 g. The corresponding figures for the MDECG were r = 81% and the root mean square prediction error = 64 g. These results confirm other studies showing that the conventional ECG is of only marginal value in the task of diagnosing LVH in the presence of RBBB. In contrast, the MDECG performs well both in ...
Selective transcatheter ablation of the fast and slow pathways using radiofrequency energy in patients with atrioventricular nodal reentrant tachycardia.
Authors: M RJazayeri, S LHempe, J SSra, A ADhala, ZBlanck, S SDeshpande, BAvitall, D PKrum, C JGilbert, MAkhtar
Journal: Circulation (1992)

BACKGROUNDThe safety and efficacy of selective fast versus slow pathway ablation using radiofrequency energy and a transcatheter technique in patients with atrioventricular nodal reentrant tachycardia (AVNRT) were evaluated.METHODS AND RESULTSForty-nine consecutive patients with symptomatic AVNRT were included. There were 37 women and 12 men (mean age, 43 +/- 20 years). The first 16 patients underwent a fast pathway ablation with radiofrequency current applied in the anterior/superior aspect of the tricuspid annulus. The remaining 33 patients initially had their slow pathway targeted at the posterior/inferior aspect of the right interatrial septum. The fast pathway was successfully ablated in the initial 16 patients and in three additional patients after an unsuccessful slow pathway ablation. A mean of 10 +/- 8 radiofrequency pulses were delivered; the last (successful) pulse was at a power of 24 +/- 7 W for a duration of 22 +/- 15 seconds. Four of these 19 patients developed complete atrioventricular (AV...
Body surface distributions of repolarization forces during acute myocardial infarction. I. Isopotential and isoarea mapping.
Authors: D MMirvis
Journal: Circulation (1980)

Although ST-segment abnormalities during acute myocardial infarction are clinically important, the total thoracic distribution of these repolarization potentials has not been reported. To provide this information, 24 patients with acute myocardial infarction were studied. Isopotential body surface maps were constructed from potentials sensed by 150 anterior and posterior electrodes. Patterns from 12 patients with anterior lesions demonstrated the appearance of repolarization potentials 21.3 +/- 4.6 msec before the end of the QRS complex. During the ST segment, potential distributions were characterized by a single anterior maximum that remained fixed in location but increased in intensity as repolarization progressed. Distributions in the remaining subjects with inferior lesions were analogously characterized by (1) the onset of repolarization 34.6 +/- 12.4 msec before termination of the QRS complex and (2) a single anterior minimum located on the left anterior superior thorax, with positive potentials di...
Fixation of Fully Covered Esophageal Stent With The New Over-The-Scope Clip (OTSC)
Authors: C Chálim Rebelo, N Nunes, M Flor de Lima, DB Moura, MP Santos, V Costa Santos, AC Rego, JR Pereira, N Paz, MA Duarte
Journal: Endoscopy (2021)

A 60 years-old-man, with Roux-en-Y reconstruction, presented with esophago-jejunal anastomosis stricture, refractory to balloon dilatation.Under fluoroscopic control and deep sedation, a guidewire was passed through the efferent loop. Then, a fully covered metal (WallFlexTM Esophageal 23x105mm, BostonScientific) stent was deployed and fixed on the proximal end using the stentfix OTSC (Ovesco Endoscopy). There were no complications. The stent remains in place after 7 weeks.The design of stentfix OTSC grants a good adaptation to the gastrointestinal anatomy, without conditioning luminal obstruction. Use of stentix OTSC seems to be associated with a decreased rate of fully covered metal stent migration.
The effect of acute alterations in left ventricular afterload and beta-adrenergic tone on indices of early diastolic filling rate.
Authors: M RZile, A SBlaustein, W HGaasch
Journal: Circulation Research (1989)

The effects of an acute increase in left ventricular systolic pressure and the effects of an intravenous isoproterenol infusion on myocardial (segment) lengthening rate and chamber (minor axis dimension) filling rate were examined in 12 anesthetized dogs. Measurements of left ventricular systolic pressure (by micromanometer) and of segment length and chamber dimension transients (by ultrasonic crystals) were made in variably afterloaded beats (three-beat descending aortic cross-clamp) before and during an isoproterenol infusion that raised (+)dP/dt by 40%. During the baseline state, we found an inverse relation between the peak rate of increase in minor axis dimension [(+)dD/dt] and systolic pressure over a wide range of systolic pressures (110-160 mm Hg) and end-systolic dimensions (25-40 mm); peak (+)dD/dt and end-systolic dimension were also inversely related. During isoproterenol infusion, end-systolic dimension fell from 29.7 +/- 3.1 to 28.0 +/- 3.1 mm and (+)dD/dt increased from 79.6 +/- 8.0 to 90.1...
Subendocardial and subepicardial wall thickening during ischemia in exercising dogs.
Authors: D CHomans, ESublett, PLindstrom, TNesbitt, R JBache
Journal: Circulation (1988)

To determine whether ischemia in the exercising dog is associated with preservation of subepicardial thickening relative to subendocardial thickening, 10 dogs were chronically instrumented with circumflex artery flow probes, hydraulic occluders, and pairs of ultrasonic microcrystals for determination of wall thickness in the circumflex artery distribution. One pair of crystals spanned the entire ventricular wall (transmural), and the other spanned the outer half of the ventricular wall. Inner wall thickness was computed as the difference between transmural wall thickness and outer wall thickness. Dogs performed control treadmill exercise and exercise with a coronary stenosis that reduced circumflex artery flow to resting control levels. Percent systolic thickening at rest for the transmural, inner, and outer regions was 21.3 +/- 11.8%, 35.5 +/- 20.3%, and 10.3 +/- 5.0% (mean +/- SD), respectively. During exercise without stenosis, systolic thickening increased to 143 +/- 37% of control for outer wall crys...
Rapid whole-genome sequencing to inform COVID-19 outbreak response in Vietnam
Authors: Nguyen Van Vinh Chau, Nguyen Thi Thu Hong, Nghiem My Ngoc, Nguyen To Anh, Huynh Trung Trieu, Le Nguyen Truc Nhu, Lam Minh Yen, Ngo Ngoc Quang Minh, Nguyen Thanh Phong, Nguyen Thanh Truong, Le Thi Thu Huong, Tran Nguyen Hoang Tu, Le Manh Hung, Tran Tan Thanh, Nguyen Thanh Dung, Nguyen Tri Dung, Guy Thwaites, Le Van Tan
Journal: Journal of Infection (2021)
An evaluation of right and left ventricular function after anatomical correction and intra-atrial repair operations for complete transposition of the great arteries.
Authors: R PMartin, S AQureshi, J AEttedgui, E JBaker, B JO'Brien, P BDeverall, A KYates, M NMaisey, RRadley-Smith, MTynan
Journal: Circulation (1990)

Anatomical correction of complete transposition of the great arteries has the potential advantage over intra-atrial repair in that the left ventricle becomes the systemic pump. To investigate the importance of this, we evaluated right and left ventricular function in 21 patients after anatomical correction and in 21 patients after Mustard or Senning operations. First-pass and equilibrium-gated radionuclide angiography were used to measure right and left ventricular ejection fractions between 17 and 78 (mean, 47) months after anatomical correction and between 3 and 187 (mean, 67) months after intra-atrial repair. The mean age of the patient groups at the time of study was 52 and 84 months, respectively. The right ventricular ejection fraction ranged from 35% to 78% (mean, 58%) in patients after anatomical correction and from 27% to 68% (mean, 51%) after intra-atrial repair (p = 0.066). The left ventricular ejection fraction ranged from 39% to 74% (mean, 58%) after anatomical correction and from 35% to 74% ...
Plasma cyclic adenosine 3':5'-monophosphate response to isoproterenol and glucagon in hyperkinetic borderline (labile) hypertension.
Authors: F HMesserli, OKuchel, PHamet, GTolis, G PGuthrie, JFraysse, WNowaczynski, JGenest
Journal: Circulation Research (1976)

The hemodynamic changes observed in patients with the  form of borderline (labile) essential hypertension (BEH) could be related to the hyperresponsiveness of cardiac beta-adrenergic receptors to catecholamines. The isoproterenol-induced increase in plasma cyclic adenosine 3':5'-monophosphate (cAMP) reflects the response of adenylate cyclase to beta-adrenergic stimulation, whereas a non-beta-receptor-mediated increase occurs with the administration of glucagon. Both substances were infused into 13 control subjects and 14 patients with the hyperkinetic form of BEH before and after propranolol administration. Baseline plasma cAMP concentrations were comparable in both groups. After 30 minutes of isoproterenol infusion (20 ng/kg per min) a significantly higher increase in plasma cAMP and heart rate and a smaller decrease in diastolic blood pressure were seen in this type of BEH than in control subjects. The increase in plasma cAMP and in heart rate correlated positively when all subjects were c...
Effects of propranolol and nifedipine on exercise-induced attack in patients variant angina: assessment by exercise thallium-201 myocardial scintigraphy with quantitative rotational tomography.
Authors: KKugiyama, HYasue, YHorio, YMorikami, HFujii, YKoga, AKojima, MTakahashi
Journal: Circulation (1986)

To examine the effects of propranolol and nifedipine on exercise-induced attack in patients with variant angina, exercise 201Tl myocardial scintigraphy with quantitative analysis by emission-computed tomography was performed in 20 patients with variant angina after oral propranolol (80 mg), nifedipine (20 mg), and placebo. Exercise-induced attack occurred in 11 patients on placebo, in 14 on propranolol, and in none on nifedipine. The exercise duration was significantly shorter in those on propranolol (p less than .05), but significantly longer in patients on nifedipine (p less than .05) than in those on placebo. The peak rate-pressure product was significantly lower in patients on propranolol (p less than .01), but did not change in those on nifedipine, as compared with that in patients on placebo. The size of the perfusion defect as measured by 201Tl tomography was significantly greater in patients on propranolol (p less than .05), but significantly less in those on nifedipine (p less than .01) than in t...
109P Real-world evaluation of pembrolizumab monotherapy for PD-L1 positive (TPS&gt;50%) metastatic NSCLC in France
Authors: M. Pérol, T. Filleron, X. Quantin, C. Chouaid, C. Audigier Valette, H. Lena, C. Kaderbhai, C. Fabre, M. Santorelli, L. Bensimon, T. Burke, D. Couch, E. Nguyen, C. Courtinard
Journal: Journal of Thoracic Oncology (2021)
Shall The Journal be Removed to Washington?
Authors: S. S. Bishop
Journal: JAMA (1891)

<h3>To the Editor:</h3> —I have been waiting patiently to hear the arguments that our Eastern friends rely on to effect the removal ofThe Journalto Washington. I have been impressed with most of them as applying with increased force to Chicago. Leaving out the question of politics, there appears to be nothing in this agitation. But the fact that the next meeting of the Association will occur in the city that is a candidate for the location ofThe Journalrenders it necessary to thoroughly canvass the merits of the case before a vote is taken. There is always a large attendance of the local members of the profession wherever the meetings are held. Washington, Baltimore, Pittsburgh, Philadelphia, New York and other Eastern and Southern cities will be more largely represented than they would be if the meeting were to be held in some other section of the country.
Myocardial infarction in Mexican-Americans and non-Hispanic whites. The San Antonio Heart Study.
Authors: B DMitchell, H PHazuda, S MHaffner, J KPatterson, M PStern
Journal: Circulation (1991)

Mexican-American men experience reduced cardiovascular mortality compared with non-Hispanic white men. There is no corresponding ethnic difference in cardiovascular mortality in women. The difference in men could result either from a lower incidence of cardiovascular disease or a lower case fatality rate among Mexican-Americans. Although the incidence of cardiovascular disease in Mexican-Americans is unknown, we have collected data on prevalence of myocardial infarction in 5,148 individuals examined in the San Antonio Heart Study, a population-based survey of cardiovascular disease conducted between 1979 and 1988 in Mexican-Americans and non-Hispanic whites aged 25-64 years. Myocardial infarction was assessed by Minnesota-coded electrocardiograms and by a self-reported history of a physician-diagnosed heart attack. For both end points, the age-adjusted prevalence of myocardial infarction was lower in Mexican-American men than in non-Hispanic white men. After adjustment for age and diabetes status (present...
Sex differential in the relationship of electrocardiographic ST-T abnormalities to risk of coronary death: 11.5 year follow-up findings of the Chicago Heart Association Detection Project in Industry.
Authors: YLiao, KLiu, ADyer, J ASchoenberger, R BShekelle, PCollette, JStamler
Journal: Circulation (1987)

The independent contributions of ST segment depression and/or T wave abnormality (ST-T abnormalities) on the baseline resting electrocardiogram to risk of 11.5 year coronary heart disease (CHD) mortality were explored among 9203 white men and 7818 white women who were 40 to 64 years old and without definite CHD at entry in the Chicago Heart Association Detection Project in Industry. At baseline, prevalence rates of ST-T abnormalities were age related for both sexes, and at every age the rate was higher in women than men (age-adjusted prevalence rates 12.3% and 8.1%, respectively). Univariate analysis showed that ST-T abnormalities were associated with significantly increased risk of death from CHD for both men and women. However, men with ST-T abnormalities had much greater age-adjusted and multiple risk factor-adjusted absolute excess risk and relative risk than women with such electrocardiographic abnormalities. When baseline age, diastolic pressure, serum cholesterol, cigarettes/day, history of diabete...
Augmented and sustained plasma concentrations after intramuscular injections of molecular variants and deglycosylated forms of tissue-type plasminogen activators.
Authors: B ESobel, S JSarnoff, D ANachowiak
Journal: Circulation (1990)

We have previously explored induction of coronary thrombolysis with tissue-type plasminogen activator (t-PA) administered intramuscularly. Absorption-enhancing agents that rendered the approach feasible were identified, but large amounts of activator were required and initial elevations of concentrations in plasma could not be sustained. The present study was designed to determine whether more therapeutically favorable plasma concentrations could be induced by genetically engineering or chemically modifying t-PA to prolong its half-life based on the hypothesis that the ratio of absorption to clearance would be increased. Each of four genetically engineered variants (one variant with growth factor and kringle 1 domains deleted and kringle 2 duplicated, a second variant with a cysteine for Arg substitution in the growth factor domain, a third variant with an additional urokinase kringle inserted, and a fourth variant with the growth factor domain deleted) and enzymatically deglycosylated t-PA exhibited prol...
Detection of Colonic Polyps In India – a Large Retrospective Cohort Study (DOCPI-R)
Authors: N Jagtap, P Inavolu, A Singh, S Godbole, P Ambardekar, S Lakhtakia, M Ramchandani, Z Nabi, R Talukdar, A Sekaran, M Tandan, R Kalapala, R Gupta, PM Reddy, SF Memon, GV Rao, DN Reddy
Journal: Endoscopy (2021)

Aims Colorectal cancer (CRC) is an emerging public health problem in Asia and India. However, there is scarcity of data on CRC and adenoma. We aimed to study prevalence and characteristics of colonic polyps in large retrospective cohort.