tbuckley/cabot-search huggingface dataset:
Celecoxib for Stage III Colon Cancer
Authors: David J. Kerr, Sarah Chamberlain, Rachel S. Kerr
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myocardial function and transmural blood flow during coronary venous retroperfusion in pigs.
Authors: B HOh, MVolpini, MKambayashi, KMurata, H ARockman, G SKassab, JRoss
Journal: Circulation (1992)

BACKGROUNDThe degree of recovery of regional myocardial contraction during coronary venous retroperfusion has not been well established, particularly in the absence of coronary collateral channels. Therefore, the maximal functional benefit attainable with coronary venous retroperfusion was assessed in pigs by means of using selective pump retroperfusion of the left anterior descending vein, with venting of the left anterior descending artery to zero pressure.METHODS AND RESULTSIn eight anesthetized open-chest pigs during selective left anterior descending venous retroperfusion over a range of retroperfusion flows, regional myocardial function (percent systolic wall thickening by sonomicrometry) increased progressively to an average of 62% of control values at a retroperfusion flow rate 200% of control arterial flow. Progressive thickening of the end-diastolic dimension of the anterior wall was observed with increasing retroperfusion flow (from 8.7 +/- 0.9 to 10.7 +/- 2.3 mm, p less than 0.001). Perfusion ...
Single amino acid substitutions within the ion permeation pathway alter single-channel conductance of the human L-type cardiac Ca2+ channel.
Authors: AYatani, ABahinski, GMikala, SYamamoto, ASchwartz
Journal: Circulation Research (1994)

Voltage-dependent L-type Ca2+ channels select for Ca2+ and other divalent cations by high-affinity Ca2+ binding and ion-ion interactions in the permeation pathway. We have recently identified a series of highly conserved glutamate residues, located within the SS2 segments of each of the four repeats of the human heart Ca2+ channel alpha 1 subunit, as major determinants of ion selectivity of the channel. To further investigate the functional role of these glutamate residues in ion permeation, we have individually neutralized the glutamic acids in repeats II and IV by substitution with alanine or glutamine. Wild-type and mutant Ca2+ channels were expressed in Xenopus oocytes. Apparent affinity for external Ca2+ was assessed by measuring the block by Ca2+ of inward Li+ currents through the Ca2+ channels. Mutations reducing net negative charge at these positions resulted in a 10-fold reduction in the affinity of the channel for external Ca2+. Single-channel conductance was measured with either divalent or mon...
Calcaneus involvement by multiple myeloma
Authors: Masanori Daibata, Kentaro Bandobashi, Hirokuni Taguchi
Journal: American Journal of Hematology (2005)

about the Tsarevich Alexei, his illness, and the ''mad monk'' Gregory Rasputin.Regardless of the illness of the Tsarevich, the infamous Rasputin was the guardian angel to the Tsarevich.Through hypnosis, the monk could relax the boy, alleviate his pain, and put him to sleep.By doing so, he might have decreased the boy's bleeding and also relaxed the parents and the rest of the Royal Court.The monk did for the boy what the medical professors at the universities failed to do.Perhaps for that, the Tsarina was too grateful to the monk.Rasputin was not a healer; he did not cure but he provided symptomatic treatment to the boy.Another historical perspective: Earlier in my career as a student of Professor Leandro M. Tocantins, M.D. , and later as a member of the faculty, I attended hemophilic patients; we worked with 100 families.Dr. Tocantins, Director of the Cardeza Foundation for Hematologic Research and internationally known for his work on hemophilia, accepted the use of hypnosis for hemophilic patients undergoing dental work at a time when only fresh-frozen plasma (FFP) was available.I witnessed several of these patients in the dental clinic.
Differential effect of global ischemia on the ryanodine-sensitive and ryanodine-insensitive calcium uptake of cardiac sarcoplasmic reticulum.
Authors: J JFeher, W RLeBolt, N HManson
Journal: Circulation Research (1989)

The effect of ischemia on the function of cardiac sarcoplasmic reticulum (SR) was assessed by the calcium uptake rate of rat whole-heart homogenates in the presence of 10 mM oxalate. Previous studies have shown that this uptake is restricted to the SR. The contribution of the ryanodine-sensitive fractions of the SR to the total homogenate uptake was assessed by using 20 microM ruthenium red and 625 microM ryanodine to close the SR calcium release channel under previously established optimal conditions. Global ischemia of 10, 15, 30, and 60 minutes depressed homogenate calcium uptake rate 19 +/- 2%, 50 +/- 6%, 65 +/- 3%, and 81 +/- 5%, respectively. This decrease was not observed when the uptake rates were measured after closure of the calcium channel with ryanodine or ruthenium red. Similar results were obtained with a Langendorff in vitro perfusion preparation, in which calcium uptake was decreased 35 +/- 5%, 37 +/- 8%, 58 +/- 7%, and 64 +/- 4% after 10, 15, 30, and 60 minutes of ischemia, but no signifi...
Selective radiofrequency ablation of the slow pathway for the treatment of atrioventricular nodal reentrant tachycardia. Evidence for involvement of perinodal myocardium within the reentrant circuit.
Authors: G NKay, A EEpstein, S MDailey, V JPlumb
Journal: Circulation (1992)

BACKGROUNDThe circuit of atrioventricular (AV) nodal reentrant tachycardia may include perinodal atrial myocardium. Furthermore, in patients with dual AV nodal pathways, the atrial insertion of the slow pathway is likely to be located near the ostium of the coronary sinus, caudal to the expected location of the AV node. The present study was designed to evaluate the safety and efficacy of selective catheter ablation of the slow pathway using radiofrequency energy applied along the tricuspid annulus near the coronary sinus ostium as definitive therapy for AV nodal reentrant tachycardia.METHODS AND RESULTSAmong 34 consecutive patients who were prospectively enrolled in the study, the slow pathway was selectively ablated in 30, and the fast pathway was ablated in four. Antegrade conduction over the fast pathway remained intact in all 30 patients after successful selective slow pathway ablation. There was no statistically significant change in the atrio-His interval (68.5 +/- 21.8 msec before and 69.6 +/- 23....
Transcapillary water and protein flux in the canine intestine with acute and chronic extrahepatic portal hypertension.
Authors: C LWitte, J FMyers, M HWitte, M AKatz
Journal: Circulation Research (1983)

Intestinal transcapillary water and total protein flux were determined in dogs with chronic extrahepatic portal hypertension after construction of an aortic-portal shunt combined with hilar portal vein constriction and compared to acute portal vein constriction. Measurements were made of thoracic duct lymph flow, portal venous pressure, and total protein concentration in plasma, thoracic duct lymph, intestinal and liver lymph. From these data and calculations based on the dual visceral origin of thoracic duct lymph from liver and intestine, intestinal transcapillary water flux in chronic extrahepatic portal hypertension (portal venous pressure = 21.4 +/- 2 mm Hg; mean +/- SEM), increased 5-fold (93 +/- 12 from 17 +/- 4 microliters/min/kg, P less than 0.001), while intestinal total protein flux expressed as protein clearance (intestinal transcapillary water flux X intestinal lymph/plasma total protein concentration) was unchanged (13 +/- 3 from 10 +/- 2 microliters/min per kg; P greater than 0.4), a findin...
Influence of hypoxia on adrenergic modulation of triggered activity in isolated adult canine myocytes.
Authors: S GPriori, K AYamada, P BCorr
Journal: Circulation (1991)

Although findings from several reports suggest that nonreentrant or focal mechanisms contribute to the genesis of arrhythmias during early ischemia, the contribution of triggered activity arising from early or delayed afterdepolarizations has not been resolved. We have previously demonstrated that beta- but not alpha-adrenergic stimulation induces afterdepolarizations and triggered activity in isolated normoxic myocytes. In the present study, the influence of the extent of cellular derangements as well as increases in [K+]o on alpha- and beta-adrenergic-mediated afterdepolarizations and triggered activity was evaluated. Adult canine myocytes were exposed to one of the following experimental conditions with simultaneous intracellular transmembrane action potential recordings: 1) low PO2 (less than 10 mm Hg, obtained using a specially designed hypoxic chamber) and low (6.8) pH; 2) low PO2, low pH, and high extracellular potassium ([K+]o) (10 mM); or 3) severe metabolic inhibition with cyanide (10(-6) M). Ce...
Local drug delivery systems as therapeutic strategies against periodontitis: A systematic review
Authors: Ying Wei, Yaxin Deng, Shuting Ma, Meixin Ran, Yannan Jia, Jia Meng, Fei Han, Jingxin Gou, Tian Yin, Haibing He, Yanjiao Wang, Yu Zhang, Xing Tang
Journal: Journal of Controlled Release (2021)
Platelet aggregation in partially obstructed vessels and its elimination with aspirin.
Authors: J DFolts, E BCrowell, G GRowe
Journal: Circulation (1976)

In 35 open chest anesthetized dogs coronary and aortic blood flow were measured with electromagnetic flowmeters while aortic and distal coronary blood pressure and an epicardial ECG were recorded. A fixed amount of stenosis (60-80%) was produced in the coronary artery by an externally applied plastic cylinder. In 24 of the 35 dogs the coronary blood flow showed cyclical reductions to near zero, with a sudden spontaneous return to near control levels. During reduced flow the epicardial ECG showed ST-segment depression suggestive of ischemia, and ventricular premature beats were often noted. Six animals died acutely during episodes of reduced flow. After 35 mg/kg of aspirin were given intravenously the cyclical reductions in coronary blood flow were abolished and the in vitro platelet aggregations were reduced from a control of 62.1 +/- 15 units (Born technique) to an average of 23.7 +/- 12 units. Histologic sections of the narrowed coronary artery obtained when coronary flow was reduced show an amorphous m...
Vasopressin increases cytosolic free [Ca2+] in the neonatal rat cardiomyocyte. Evidence for V1 subtype receptors.
Authors: Y JXu, VGopalakrishnan
Journal: Circulation Research (1991)

Radioligand binding studies of the cardiac arginine vasopressin (AVP) receptor, together with studies on the AVP-evoked alterations in the [Ca2+]i levels, were undertaken using primary cultures of neonatal rat cardiomyocytes. Rapid, reversible, specific, high-affinity and low-capacity binding sites were detected for the agonist, [3H]AVP, and the V1 selective antagonist, d(CH2)5 Tyr (Me)-[3H]AVP (V1 antagonist), radioligands. The V2 selective antagonist radioligand, d(CH2)5 D-Ile des-Gly NH2-[3H]AVP, showed very little binding even at very high concentrations. [3H]AVP and [3H]V1 antagonist specific binding attained equilibrium in 10 minutes at 37 degrees C. The Kd and Bmax values (mean +/- SEM) were [3H]AVP: Kd 1.44 +/- 0.18 nM; Bmax 5,253 +/- 590 sites/cell; [3H]V1 antagonist: Kd 0.96 +/- 0.10 nM; Bmax 6,869 +/- 485 sites/cell. Ki values for a series of AVP-related peptide analogues and antagonists determined by competitive inhibition of [3H]AVP binding were consistent with the saturation data. The result...
Rovalpituzumab Tesirine as a Maintenance Therapy After First-Line Platinum-Based Chemotherapy in Patients With Extensive-Stage–SCLC: Results From the Phase 3 MERU Study
Authors: Melissa L. Johnson, Zanete Zvirbule, Konstantin Laktionov, Aslaug Helland, Byoung Chul Cho, Vanesa Gutierrez, Benoît Colinet, Herve Lena, Martin Wolf, Maya Gottfried, Isamu Okamoto, Cor van der Leest, Patricia Rich, Jen-Yu Hung, Christina Appenzeller, Zhaowen Sun, David Maag, Yan Luo, Caroline Nickner, Alena Vajikova, Philip Komarnitsky, Jair Bar
Journal: Journal of Thoracic Oncology (2021)
Hairy Cell Leukemia
Authors: R C Braylan, J S Burke
Journal: Annual Review of Medicine (1979)

Hairy cell leukemia, or leukemic reticuloendotheliosis, is a chronic leu­ kemia that has received increased attention in recent years. Much of the current vogue in the recognition of this disease may be due to the employ­ ment of the term   first used by Schrek & Donnelly (1) to describe the villous cytoplasmic projections of the leukemic cells as viewed under phase microscopy. Because of the curious nature of the hairy cell, there has been considerable interest in attempting to define the cytogenesis, natural history, and factors necessary for accurate diagnosis and effective therapy of this disease.
Medical Use of Marijuana
Authors: Schwartz Richard H.
Journal: Annals of Internal Medicine (1992)

Letters1 August 1992Medical Use of MarijuanaSchwartz Richard H., MDSchwartz Richard H., MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-3-268_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:In a letter reporting the preliminary results of an anonymous survey of members of the American Society of Clinical Oncology (ASCO), Doblin and Kleiman (1) acknowledge the "possibility of response bias" and that their results "only roughly estimate the views of oncologists." In fact, 57% of those surveyed did not return their questionnaires, and the number of questionnaires returned unanswered is not stated. Further, the authors chose not to include respondents who filled out the survey but who indicated no opinion on the question (30% of the respondents); instead they stated that "of the respondents who expressed...References1. DoblinKleiman RM. Medical use of marijuana. Ann Intern Med. 1991;114:809-10. LinkGoogle Scholar2. Doblin R. Marijuana: a question of currently accepted medical use. In: RC Randall; ed. Cancer Treatment and Marijuana Therapy. Washington, D.C: Galen Press; 1990:341-52. Google Scholar3. . Program proceedings of the American Journal of Clinical Oncology [Abstract no. 1214]. Am J Clin Oncol. 1991; 10:342. Google Scholar4. DoblinKleiman RM. Marijuana as antiemetic medicine: a survey of oncologists' experiences and attitudes. Am J Clin Oncol. 1991 ;9: 1314-9. CrossrefGoogle Scholar1. DoblinKleiman RM. Medical use of marijuana. Ann Intern Med. 1991;114:809-10. LinkGoogle Scholar1. U.S. Department of Justice, Drug Enforcement Administration. Marijuana scheduling petition: final order. Federal Register. 1992 Mar 26;57:10499-508. Google Scholar2. Public Health Service denying new requests for medicinal marijuana. Internal Medicine News & Cardiology News. 1992 May 1;25:31. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1992Volume 117, Issue 3Page: 268-269KeywordsMarijuanaQuestionnaires ePublished: 1 December 2008 Issue Published: 1 August 1992 PDF downloadLoading ...
Exposure to environmental tobacco smoke increases myocardial infarct size in rats.
Authors: B QZhu, Y PSun, R ESievers, S AGlantz, W WParmley, C LWolfe
Journal: Circulation (1994)

BACKGROUNDExposure to environmental tobacco smoke (ETS) has been epidemiologically linked to death from ischemic heart disease in nonsmokers. In this study, we evaluated the influence of 3 days, 3 weeks, and 6 weeks of ETS exposure on myocardial infarct size in a rat ischemia/reperfusion model.METHODS AND RESULTSSprague-Dawley rats exposed to ETS (four Marlboro cigarettes per 15 minutes, 6 hours per day, 5 days per week) for 3 days (n = 24), 3 weeks (n = 21), or 6 weeks (n = 12) and control rats (n = 24, n = 21, and n = 12, respectively) were subjected to 35 minutes of left coronary artery occlusion and 2 hours of reperfusion. Infarct size and risk area were determined by triphenyltetrazolium chloride and phthalocyanine blue staining, respectively. Air nicotine, carbon monoxide, and total particulates were measured during ETS exposure. Serum lipids, plasma carbon monoxide hemoglobin (COHb), nicotine, and cotinine concentrations were measured in additional groups (6 to 13 rats each) exposed to 3 days, 3 we...
Spiral waves of excitation underlie reentrant activity in isolated cardiac muscle.
Authors: A MPertsov, J MDavidenko, RSalomonsz, W TBaxter, JJalife
Journal: Circulation Research (1993)

The mechanism of reentrant ventricular tachycardia was studied in computer simulations and in thin (approximately 20 x 20 x 0.5-mm) slices of dog and sheep ventricular epicardial muscle. A two-dimensional matrix consisting of 96 x 96 electrically coupled cells modeled by the FitzHugh-Nagumo equations was used to analyze the dynamics of self-sustaining reentrant activity in the form of elliptical spiral waves induced by premature stimulation. In homogeneous anisotropic media, spirals are stationary and may last indefinitely. However, the presence of small parameter gradients may lead to drifting and eventual termination of the spiral at the boundary of the medium. On the other hand, spirals may anchor and rotate around small discontinuities within the matrix. Similar results were obtained experimentally in 10 preparations whose electrical activity was monitored by means of a potentiometric dye and high-resolution optical mapping techniques; premature stimulation triggered reproducible episodes of sustained...
Evidence against significant resting sympathetic coronary vasoconstrictor tone in the conscious dog.
Authors: W MChilian, R BBoatwright, TShoji, D MGriggs
Journal: Circulation Research (1981)

The primary objective of this study was to ascertain whether resting coronary blood flow is under tonic restraint due to sympathetically mediated alpha-adrenergic coronary vasoconstriction. To accomplish this, we first developed and verified a technique for selectively sympathectomizing the posterior region of the canine left ventricle. This technique entailed the topical application of phenol in a thin line to specific sites on the myocardium and epicardial vessels. As part of the verification, we demonstrated that left stellate nerve stimulation caused increases in the myocardial extraction ratios for oxygen and lactate in the normally innervated region (I) of the ventricle, but not in the sympathectomized region (Sx). We then measured regional myocardial blood flow with microspheres in phenol-treated animals under conscious, resting conditions. The animals were acclimated to the laboratory environment, and their arterial plasma norepinephrine levels averaged 135 +/- 37 pg/ml. heart rate (81 +/- 3 bpm) ...
The effect of prostaglandin A1 on renin and aldosterone in man.
Authors: M SGolub, P FSpeckart, P KZia, RHorton
Journal: Circulation Research (1976)

Blood pressure, pulse rate, plasma aldosterone (PA), renin, and cortisol were monitored during graded intravenous infusions of prostaglandin At (PGA)1), 0.075-0.6 mug/kg min-1, alone and superimposed on angiotensin II (A II) administration in five normal men. The infusions of PGA1 did not affect blood pressure, but did progressively increase the pulse rate up to 15.2 +/- 2.0 (SEM- beats/min at the highest prostaglandin dose (0.6 mug/kg min-1). Both PA and plasma renin activity (PRA) increased in a dose-related fashion in response to the prostaglandin infusions. Aldosterone increased from a control of 4.8 +/- 0.4 to 20.7 +/- 1.2 ng and PRA increased from 0.9 +/- 0.1 to 5.4 +/- 0.4 ng/ml hr-1 at the dose of 0.6 mug/kg min-1. The correlation between the aldosterone and renin values was r = 0.85 P less than 0.001. In separate experiments, acute volume expansion with 2 liters of saline did not affect the increase in renin activity induced by exogenous prostaglandin. A II (5 ng/kg min-1) increased aldosterone a...
TCTAP A-021 Safety and Efficacy of Two–stent Strategy Versus One–stent Strategy for Bifurcation Lesion: Meta-analysis with Time Frame Follow Up
Authors: Hendy Bhaskara Perdana Putra, Ragil Nur Rosyadi, Benny Jovie, Richardus Rukma Juslim, Tjatur Bagus Gunarto, Tony Elia Parengkuan
Journal: Journal of the American College of Cardiology (2021)
<i>JAMA</i> editor is placed on leave after controversial podcast on structural racism
Authors: Janice Hopkins Tanne
Journal: BMJ (2021)

Howard Bauchner, the editor in chief of the Journal of the American Medical Association ( JAMA ), was placed on administrative leave last week (25 March) after controversy over a podcast on racism in medicine hosted by deputy editor Ed Livingston.1

The podcast has been withdrawn, Livingston has resigned, and Bauchner posted an apology online.2 He said, “Comments made in the podcast were inaccurate, offensive, hurtful, and inconsistent with the standards of JAMA .” James Madara, head of the American Medical Association, which publishes JAMA , also apologised for the podcast.

Phil Fontanarosa, JAMA ’s executive editor, will serve as interim editor, …
Late postoperative hemodynamic results and cineangiocardiographic findings after Mustard atrial baffle repair for transposition of the great arteries.
Authors: P MClarkson, J MNeutze, B GBarratt-Boyles, P WBrandt
Journal: Circulation (1976)

Forty-nine patients with transposition of the great arteries who underwent a Mustard atrial baffle repair between 1964 and 1971 were assessed late postoperatively. There have been five late deaths: two related to baffle obstruction, two from noncardiac causes, and one sudden and unexpected. Hemodynamic data were available in 42 patients and autopsy in four. Obstruction of the lower venous channel was not encountered. Three patients had severe obstruction of the upper venous channel and in four there was mild restriction. Two patients had severe pulmonary venous obstruction resulting in late death; mild asymptomatic obstruction could not be excluded with certainty in six patients. Tricuspid incompetence was infrequently encountered in patients with an essentially intact ventricular septum. Left ventricular outflow tract obstruction was found in eight patients. In three it was present after satisfactory but incomplete surgical relief and in five it had not been recognized prior to operation. In only one of ...