tbuckley/cabot-search huggingface dataset:
Oxygen consumption and hemodynamic response of exercises used in training of patients with recent myocardial infarction.
Authors: G FFletcher, J DCantwell, E WWatt
Journal: Circulation (1979)

We investigated oxygen consumption (ml/kg/min) and hemodynamic response (peak heart rate-systolic blood pressure product) to individual exercise activities before and after exercise training in 22 male postmyocardial infarction patients (PMIP). Activities included swimming, walk/jogging, volleyball, calisthenics and exercise dance routines. Oxygen consumption was determined immediately after exercise by the Douglas bag gas collection procedure and, in selected patients, by a Max Planck respirometer during exercise. Hemodynamic data were obtained by pulse count and cuff sphygmomanometer. The increase in oxygen consumption and the decrease in rate-pressure product after each activity were significant (p less than or equal to 0.01). There were no differences in oxygen consumption between the Max Planck respirometer technique and collection (Douglas bag method) immediately after exercise. The oxygen consumption obtained for PMIP compared with available cumulative data on normal subjects is significantly varia...
Leptin Is Associated with the Degree of Anemia and the Erythropoietin Levels in β Thalassemia Patients
Authors: Lila Mahagna, Osama Tanous, Tal Dujovny, Harel Eitam, Refaat Masalha, Raul Colodner, Ariel Koren, Carina Levin
Journal: Blood (2017)
Comparison of the cardiocirculatory effects of exercise and isoproterenol in children with pulmonary or aortic valve stenosis.
Authors: N JTruccone, C NSteeg, RDell, W MGersony
Journal: Circulation (1977)

Isoproterenol infusion during cardiac catheterization as a simulator of exercise was evaluated with hemodynamic studies in children with pulmonary (15) or aortic (8) valve stenosis. Cardiac function was monitored during rest, mild exercise and isoproterenol infusion. Similar heart rates were maintained in both procedures. Peak pulmonary and aortic valve gradients as well as right and left ventricular dp/dt/p were significantly higher and cardiac index significantly lower with isoproterenol as compared to exercise. Isoproterenol induced a significantly greater decrease in systemic vascular resistance, and systemic blood pressure than did exercise. Left ventricular systolic pressure rose to similar levels and this resulted in substantially higher peak aortic gradients with isoproterenol. A consistent correlation was observed for peak valvular gradients measured during exercise and isoproterenol in both groups of patients. Accordingly, regression equations were obtained allowing reasonably accurate predictio...
Right heart function during left heart assist and the effects of volume loading in a canine preparation.
Authors: D JFarrar, P GCompton, HDajee, J DFonger, J DHill
Journal: Circulation (1984)

A significant fraction of patients in whom mechanical left ventricular assist devices are implanted for refractory cardiac failure after open heart surgery have had the complication of right heart failure. To evaluate the effects of left ventricular assistance and pressure unloading on right ventricular function, we performed experiments in the normal hearts of open-chest, anesthetized, large mongrel dogs. We compared right ventricular function before and after left ventricular-to-aortic bypass with a roller pump at right atrial pressure levels of 1, 3, 5, and 7 mm Hg produced by volume loading. No significant changes were found in cardiac output or stroke volume over this range of right atrial pressures when comparing that before to that during left ventricular bypass, which at a right atrial pressure of 1 mm Hg reduced peak left ventricular pressure from 96 +/- 6 to 15 +/- 9 mm Hg and at a right atrial pressure of 5 mm Hg reduced it from 113 +/- 3 to 29 +/- 12 mm Hg, while maintaining aortic pressure. T...
Renal afferents signaling diuretic activity in the cat.
Authors: SGenovesi, FPieruzzi, PWijnmaalen, LCentonza, RGolin, AZanchetti, AStella
Journal: Circulation Research (1993)

Mechanoreceptors and chemoreceptors have been identified inside the kidney, but their functional role is still largely unclear. The aim of this study was to investigate whether changes in urine output could modify the discharge rate of renal afferent fibers. Experiments were performed in anesthetized cats in which afferent renal nerve activity (ARNA) was recorded by standard electrophysiological techniques from a centrally cut renal nerve. Arterial pressure, renal blood flow velocity, urine flow rate, and renal pelvic pressure were also measured. Three diuretic maneuvers were tested in the same cat: intravenous administration of physiological saline (8 to 13 mL/min for 2 minutes), furosemide (1 mg/kg), and atrial natriuretic peptide (ANP, 1 microgram/kg). The three maneuvers increased urine flow rate and pelvic pressure, respectively, 137.0 +/- 20.6% and 136.8 +/- 21.1% (saline), 148.6 +/- 31.7% and 139.6 +/- 43.5% (furosemide), and 75.9 +/- 7.9% and 62.1 +/- 21.2% (ANP) at the time of the maximum respons...
Quantitative two-dimensional echocardiographic analysis of motion and thickening of the interventricular septum after cardiac surgery.
Authors: TForce, PBloomfield, J EO'Boyle, D APietro, R WDunlap, S FKhuri, A FParisi
Journal: Circulation (1983)

Septal and lateral wall motion and septal thickening were evaluated with quantitative two-dimensional echocardiography in 20 patients who underwent cardiac surgery without complications. Postoperative mean ejection fraction (48 +/- 10%) measured by radionuclide ventriculography was unchanged from the preoperative value (45 +/- 8%). Mean postoperative systolic thickening of the septum (33 +/- 15%) was also unchanged from the preoperative value (26 +/- 10%). However, septal endocardial motion as measured by an external frame-of-reference (fixed-axis) system fell from a 22 +/- 10% mean percent shortening (MPS) of septal radii to a postoperative value of -8 +/- 15% (p less than .001). Fixed-axis analysis also led to an increase in MPS of lateral radii: preoperative 16 +/- 5%; postoperative 28 +/- 9% (p less than .001). With an internal frame-of-reference (floating-axis) system, which compensates for the effects of translation and rotation on wall motion, postoperative MPS of septal radii (22 +/- 10%) was unch...
Bleeding After Endoscopic Submucosal Dissection: The Role of Antithrombotic Drugs
Authors: J Revés, C Frias Gomes, C Nascimento, B Morão, C Gouveia, C Palmela, J Torres, M Cravo, L Glória, A Ferreira
Journal: Endoscopy (2021)

Aims Bleeding is one of the most frequent complications of endoscopic submucosal dissection (ESD). Our aim is to evaluate the predictors of bleeding after ESD, namely the role of antithrombotic drugs, including anticoagulants and anti-platelet drugs.
Atriopeptin III induces early relaxation of isolated mammalian papillary muscle.
Authors: A LMeulemans, K RSipido, S USys, D LBrutsaert
Journal: Circulation Research (1988)

Atrial natriuretic peptide, released by mammalian atria in response to volume overload, induces vasodilation and natriuresis. In this study, a direct effect on cardiac mechanical performance was demonstrated. Atriopeptin III (10(-9)-10(-7) M) induced early relaxation and decreased peak twitch of isometric and isotonic twitches of isolated papillary muscles of cat and rat, without affecting maximal unloaded velocity of shortening. This effect resembled the effects of dibutyryl cyclic GMP and of sodium nitroprusside on cardiac muscle. The action of atriopeptin III, but not of dibutyryl cyclic GMP or sodium nitroprusside, was abolished by mechanically or chemically damaging the endocardial endothelial surface. Thus, the early relaxation of cardiac muscle induced by atrial natriuretic peptide may be mediated through receptors on the endocardial endothelium.
The effect of acute coronary artery occlusion on subepicardial transmembrane potentials in the intact porcine heart.
Authors: EDownar, M JJanse, DDurrer
Journal: Circulation (1977)

Subepicardial transmembrane potentials were recorded from intact pig hearts to observe the changes induced by acute ischemia. Ischemia shortened action potential duration, and decreased its amplitude, upstroke velocity, and resting potential. The cells were unresponsive after 12 to 15 minutes of coronary artery occlusion, yet near normal action potentials could be restored by flushing the occluded artery with saline as late as 40 minutes after occlusion. The unipolar extracellular electrogram reflected unresponsiveness by a monophasic potential. Local refractory periods initially shortened by up to 100 msec. Later, postrepolarization refractoriness occurred and refractory periods lengthened often in excess of basic cycle length, thus resulting in 2:1 responses. The onset of early ventricular arrhythmias often coincided with a period of alternation and 2:1 responses, especially when these got out of phase in different regions. Reperfusion frequently led to ventricular fibrillation, and was associated with ...
Abstract 11834: Early Reduction in Elevated Pulmonary Artery Pressures After Initiation of Sacubitril/valsartan: Insights From Ambulatory Hemodynamic Monitoring
Authors: Akshay S Desai, J. Thomas Heywood, Lisa Rathman, William T Abraham, Philip Adamson, Marie-Elena Brett, Maria R Costanzo, Nirav Raval, David Shavelle, Poornima Sood, Lynne W Stevenson
Journal: Circulation (2019)

Introduction: Compared to angiotensin converting enzyme (ACE) inhibition alone, angiotensin receptor neprilysin inhibition (ARNI) reduces cardiovascular mortality and heart failure (HF) hospitaliza...
Granulomatous Gastritis: Endoscopic and Etiological Features
Authors: S Bradai, A Khsiba, M Medhioub, A Ben Mohamed, M Mahmoudi, L Hamzaoui, MM Azzouz
Journal: Endoscopy (2021)

Aims Granulomatous gastritis (GG) is defined by the presence in the chorion of epithelioid and sometimes gigantocellular granulomas. The aim of our study is to describe the clinical and endoscopic characteristics and to determine the etiologies of GG.
Squash ball to eye ball
Authors: F M Owers
Journal: BMJ (1981)

Pharmacokinetic parameters—including tissue distribution, biliary excretion, and urinary excretion of <i>M1–M4</i>— were compared after an intravenous administration of DA-125 (a new anthracycline derivative; 20 mg/kg body weight) to male spontaneously hypersensitive rats (SHRs) at 16 weeks (an animal model for human primary hypertension) and at 6 weeks (corresponding to the early phase of the development of hypertension, at which time blood pressure remains within the normotensive range) of age and their age-matched control Kyoto-Wistar rats, and male deoxycorticosterone acetate-salt–induced Sprague-Dawley rats (DOCA-salt rats, an animal model for human secondary hypertension) at 16 weeks of age and their age-matched control Sprague-Dawley rats. Mean plasma concentrations of both<i>M2</i> and <i>M4</i>, and the resultant area under the plasma concentration-time curve from time 0 to last measured time [AUCT; <i>M2</i> (68.9 <i>vs</i>. 29.3 μg-min/ml) and<i>M4</i> (53.4 <i>vs</i>. 33.4 μg-min/ml)], increased significantly in SHRs at 16 weeks of age, compared with their control rats. Similar results were also obtained from DOCA-salt rats at 16 weeks of age, compared with their control rats. However, values were not significantly different between SHRs at 6 weeks of age and their control rats. Previous data indicated that the significant increase in plasma concentrations and the resultant AUCT values of both<i>M2</i> and <i>M4</i> in SHRs at 16 weeks of age were due to the hypertension state itself, and not to any hereditary characteristics of the SHRs. The significantly increased plasma concentrations and the resultant AUCT values of <i>M2</i> in both SHRs and DOCA-salt rats at 16 weeks of age were due to the significantly decreased biliary excretion of <i>M2</i> and possibly to the increased amount of aldo-keto reductase in the liver. However, the increase in the two aforementioned pharmacokinetic parameters in the case of <i>M4</i> were possibly due solely to the increased amount of aldo-keto reductase in the liver.
Multicenter trial of oral enoximone in patients with moderate to moderately severe congestive heart failure. Lack of benefit compared with placebo. Enoximone Multicenter Trial Group.
Authors: B FUretsky, MJessup, M AKonstam, G WDec, C VLeier, JBenotti, SMurali, H CHerrmann, J ASandberg
Journal: Circulation (1990)

A multicenter double-blind, randomized, placebo-controlled trial of oral enoximone, a phosphodiesterase inhibitor, was conducted in 102 outpatients (50 receiving enoximone and 52 receiving placebo) with moderate to moderately severe congestive heart failure. All were on a long-term regimen of digoxin and diuretics without vasodilators and converting enzyme inhibitors. Symptom score was obtained, and exercise testing was performed monthly for 4 months. There were no differences between groups in symptoms or exercise duration at the end of 4 months. A subgroup undergoing analysis of oxygen consumption with measurement of anaerobic threshold during exercise showed an increase (p less than 0.05) in anaerobic threshold at 1 month with enoximone. (2.7 +/- 0.8 ml O2/kg/min) compared with placebo (-0.8 +/- 1.2 ml O2/kg/min). This improvement was not sustained at 4 months (0.5 +/- 1.7 ml O2/kg/min with enoximone and 0.2 +/- 1.5 ml O2/kg/min with placebo). The dropout rate was significantly higher (p less than 0.02...
Coronary perfusion during acute myocardial infarction with a combined therapy of coronary angioplasty and high-dose intravenous streptokinase.
Authors: R SStack, C MO'Connor, D BMark, THinohara, H RPhillips, M MLee, N MRamirez, W GO'Callaghan, C ASimonton, E BCarlson
Journal: Circulation (1988)

Two hundred and sixteen patients with acute myocardial infarction were treated with immediate infusion of high-dose (1.5 million units) intravenous streptokinase followed by emergency coronary angioplasty. The infarct lesion was crossed and dilated in 99% and persistent coronary perfusion after the procedure was achieved in 90% (including 3% with significant residual stenosis). Total in-hospital mortality was 12%. Multivariable analysis showed a higher hospital mortality with cardiogenic shock (41% vs 5% without shock), older age, lower left ventricular ejection fraction, and female sex. Final patency of the infarct-related vessel was determined by follow-up in-hospital cardiac catheterization. Coronary reocclusion occurred in 11% (symptomatic in 7%, treated with emergency angioplasty or bypass surgery; silent in 4%, treated medically). Of the surviving patients with successful initial establishment of infarct vessel patency, 94% were discharged from the hospital with an open infarct artery or a bypass gr...
Interaction of Microbiome, Diet, and Hospitalizations Between Brazilian and American Patients With Cirrhosis
Authors: Mario R. Álvares-da-Silva, Claudia P. Oliveira, Andrew Fagan, Larisse Longo, Rutiane U. Thoen, Patricia M. Yoshimura Zitelli, Renee M. Tanaka Ferreira, Sara Mcgeorge, Amirhossein Shamsaddini, Alberto Q. Farias, Masoumeh Sikaroodi, Patrick M. Gillevet, Jasmohan S. Bajaj
Journal: Clinical Gastroenterology and Hepatology (2021)
Best of most possible worlds: Hybrid gene therapy vectors based on parvoviruses and heterologous viruses
Authors: Julia Fakhiri, Dirk Grimm
Journal: Molecular Therapy (2021)

Parvoviruses and especially the adeno-associated virus (AAV) species provide an exciting and versatile platform for the rational design or molecular evolution of human gene-therapy vectors, documented by literature from over half a century, hundreds of clinical trials, and the recent commercialization of multiple AAV gene therapeutics. For the last three decades, the power of these vectors has been further potentiated through various types of hybrid vectors created by intra- or inter-genus juxtaposition of viral DNA and protein cis elements or by synergistic complementation of parvoviral features with those of heterologous, prokaryotic, or eukaryotic viruses. Here, we provide an overview of the history and promise of this rapidly expanding field of hybrid parvoviral gene-therapy vectors, starting with early generations of chimeric particles composed of a recombinant AAV genome encapsidated in shells of synthetic AAVs or of adeno-, herpes-, baculo-, or protoparvoviruses. We then dedicate our attention to two newer, highly promising types of hybrid vectors created via (1) pseudotyping of AAV genomes with bocaviral serotypes and capsid mutants or (2) packaging of AAV DNA into, or tethering of entire vector particles to, bacteriophages. Finally, we conclude with an outlook summarizing critical requirements and improvements toward clinical translation of these original concepts.
Incidence and consequences of periprocedural occlusion. The 1985-1986 National Heart, Lung, and Blood Institute Percutaneous Transluminal Coronary Angioplasty Registry.
Authors: K MDetre, D RHolmes, RHolubkov, M JCowley, M GBourassa, D PFaxon, G RDorros, L GBentivoglio, K MKent, R KMyler
Journal: Circulation (1990)

Of 1,801 patients in the 1985-1986 Percutaneous Transluminal Coronary Angioplasty (PTCA) Registry, 122 (6.8%) had periprocedural occlusion (4.9% in the catheterization laboratory, 1.9% outside the laboratory). Baseline patient factors independently associated with increased occlusion rates included triple-vessel disease, high risk status for surgery, and acute coronary insufficiency. Lesion characteristics showing significant positive association included severe stenosis before PTCA, diffuse or multiple discrete morphology, thrombus, and collateral flow from the lesion. Intimal tear and dissection were also very strongly associated with occlusion. Sixty patients (49%) had a transient occlusion that was reopened with PTCA, 43 (35%) were not redilated and managed with bypass surgery, and 19 (16%) were not redilated and managed medically. In-hospital mortality was 5% in each of these treatment groups, compared with 1% in occlusion-free patients. In-hospital infarction rates ranged from 27% in patients with t...
Comment on Sharif et al. HDL Cholesterol as a Residual Risk Factor for Vascular Events and All-Cause Mortality in Patients With Type 2 Diabetes. Diabetes Care 2016;39:1424–1430
Authors: Zahra Aryan, Sina Noshad, Mohsen Afarideh, Alireza Esteghamati
Journal: Diabetes Care (2016)

We read with great interest the study by Sharif et al. (1) of 1,829 patients with type 2 diabetes (T2D) from the Second Manifestations of ARTerial disease (SMART) cohort. Here, we would like to suggest a different interpretation of their findings in light of the results from our ongoing cohort of Iranian patients with T2D (2). We believe that the chameleon behavior of HDL cholesterol (HDL-c) might be ascribed to the chronic systematic inflammatory status. Hence, we investigated the association of serum C-reactive protein (CRP), a marker of chronic low-grade inflammation, with HDL-c, LDL cholesterol (LDL-c), and cardiovascular events.

In our cohort of 2,607 patients with T2D who were followed for an …
Risk of HCC With Hepatitis B Viremia Among HIV/HBV‐Coinfected Persons in North America
Authors: H. Nina Kim, Craig W. Newcomb, Dena M. Carbonari, Jason A. Roy, Jessie Torgersen, Keri N. Althoff, Mari M. Kitahata, K. Rajender Reddy, Joseph K. Lim, Michael J. Silverberg, Angel M. Mayor, Michael A. Horberg, Edward R. Cachay, Gregory D. Kirk, Jing Sun, Mark Hull, M. John Gill, Timothy R. Sterling, Jay R. Kostman, Marion G. Peters, Richard D. Moore, Marina B. Klein, Vincent Lo Re
Journal: Hepatology (2021)

Background and Aims Chronic HBV is the predominant cause of HCC worldwide. Although HBV coinfection is common in HIV, the determinants of HCC in HIV/HBV coinfection are poorly characterized. We examined the predictors of HCC in a multicohort study of individuals coinfected with HIV/HBV. Approach and Results We included persons coinfected with HIV/HBV within 22 cohorts of the North American AIDS Cohort Collaboration on Research and Design (1995‐2016). First occurrence of HCC was verified by medical record review and/or cancer registry. We used multivariable Cox regression to determine adjusted HRs (aHRs [95% CIs]) of factors assessed at cohort entry (age, sex, race, body mass index), ever during observation (heavy alcohol use, HCV), or time‐updated (HIV RNA, CD4+ percentage, diabetes mellitus, HBV DNA). Among 8,354 individuals coinfected with HIV/HBV (median age, 43 years; 93% male; 52.4% non‐White), 115 HCC cases were diagnosed over 65,392 person‐years (incidence rate, 1.8 [95% CI, 1.5‐2.1] events/1,000 person‐years). Risk factors for HCC included age 40‐49 years (aHR, 1.97 [1.22‐3.17]), age ≥50 years (aHR, 2.55 [1.49‐4.35]), HCV coinfection (aHR, 1.61 [1.07‐2.40]), and heavy alcohol use (aHR, 1.52 [1.04‐2.23]), while time‐updated HIV RNA &gt;500 copies/mL (aHR, 0.90 [0.56‐1.43]) and time‐updated CD4+ percentage &lt;14% (aHR, 1.03 [0.56‐1.90]) were not. The risk of HCC was increased with time‐updated HBV DNA &gt;200 IU/mL (aHR, 2.22 [1.42‐3.47]) and was higher with each 1.0 log 10 IU/mL increase in time‐updated HBV DNA (aHR, 1.18 [1.05‐1.34]). HBV suppression with HBV‐active antiretroviral therapy (ART) for ≥1 year significantly reduced HCC risk (aHR, 0.42 [0.24‐0.73]). Conclusion Individuals coinfected with HIV/HBV on ART with detectable HBV viremia remain at risk for HCC. To gain maximal benefit from ART for HCC prevention, sustained HBV suppression is necessary.
48MO Phase I study of AMG 757, a delta-like ligand 3 (DLL3) targeting, half-life extended bispecific T-cell engager immuno-oncology therapy, in small cell lung cancer (SCLC)
Authors: L. Paz-Ares, T.K. Owonikoko, M. Johnson, R. Govindan, H. Izumi, V. Lai, H. Borghaei, M. Boyer, R.J. Boosman, H-D. Hummel, F. Blackhall, A. Dowlati, Y. Zhang, S. Mukherjee, B. Sable, A. Pati, A. Shetty, N. Hashemi Sadraei, S. Champiat
Journal: Journal of Thoracic Oncology (2021)
Splinting vs Surgery for Carpal Tunnel Syndrome—Reply
Authors: E. F. Shaw Wilgis
Journal: JAMA (2003)

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