tbuckley/cabot-search huggingface dataset:
ZMYND8 Expression in Breast Cancer Cells Blocks T-Lymphocyte Surveillance to Promote Tumor Growth
Authors: Yong Wang, Maowu Luo, Yan Chen, Yijie Wang, Bo Zhang, Zhenhua Ren, Lei Bao, Yanan Wang, Jennifer E. Wang, Yang-Xin Fu, Weibo Luo, Yingfei Wang
Journal: Cancer Research (2020)

Emerging studies indicate that DNA damage in cancer cells triggers antitumor immunity, but its intrinsic regulatory mechanism in breast cancer cells remains poorly understood. Here, we show that ZMYND8 is upregulated and inhibits micronucleus formation and DNA damage in breast cancer cells. Loss of ZMYND8 triggered activation of the DNA sensor cyclic guanosine monophosphate-adenosine monophosphate synthase in micronuclei, leading to further activation of the downstream signaling effectors stimulator of IFN genes and NF-κB, but not TANK-binding kinase 1 and IFN regulatory factor 3, thereby inducing the expression of IFNβ and IFN-stimulated genes (ISG) in breast cancer cells in vitro and tumors in vivo. ZMYND8 knockout (KO) in breast cancer cells promoted infiltration of CD4+ and CD8+ T cells, leading to tumor inhibition in syngeneic mouse models, which was significantly attenuated by treatment of anti-CD4/CD8-depleting antibodies or anti-IFNAR1 antibody and in immunodeficient Rag1 KO mice. In human breast tumors, ZMYND8 was negatively correlated with ISGs, CD4, CD8A, CD8B, and the tumor-lymphocyte infiltration phenotype. Collectively, these findings demonstrate that maintenance of genome stability by ZMYND8 causes breast cancer cells to evade cytotoxic T-lymphocyte surveillance, which leads to tumor growth. SIGNIFICANCE: These findings show that ZMYND8 is a new negative and intrinsic regulator of the innate immune response in breast tumor cells, and ZMYND8 may be a possible target for antitumor immunotherapy.
Edaravone enhances the anti-tumor effects of CPT-11 in murine colon cancer by inhibition of NF-kB
Authors: Satoshi Kokura, Naoyuki Sakamoto, Takeshi Ishikawa, Hiroshi Higashihara, Nami Nakabe, Yuji Naito, Norimasa Yoshida, Toshikazu Yoshikawa
Journal: Cancer Research (2005)

4938  Background and Aim: CPT-11 induces apoptosis in cancer cells by inhibiting the activity of topoisomerase I. However, CPT-11 is also known to activate the transcription factor NF-kB in cancer cells. Activation of NF-kB in cancer cells has been shown to attenuate apoptosis induced by chemotherapy or radiotherapy.On the other hand, some antioxidants have been reported to serve as potent NF-kB inhibitors. In this study, we investigated the ability of edaravone, a free radical scavenger, to enhance apoptosis induced by chemotherapeutic compound, CPT-11 by inhibition of NF-kB. Methods: Monolayers of colon26 mouse colon cancer cells were either pretreated or not with edaravone. Cells were subsequently treated with SN38, the active metabolite of CPT-11. Moreover, colon26 cells were inoculated either subcutaneously or via the tail vein of male BALB/c mice to establish subcutaneous tumor or lung metastasis. The mice were treated with CPT-11 and edaravone every 5 days. Results: In vitro, SN38 induced the activation of NF-kB, the production of intracellular reactive oxygen species, the activation of caspase-3, and apoptosis in colon26 cells. Pretreatment with edaravone scavenged the SN38-produced reactive oxygen species, and inhibited the SN38-induced activation of NF-kB. Moreover, edaravone enhanced the activation of caspase-3, and the level of apoptosis induced by SN38. In vivo, the combination of edaravone with CPT-11 reduced subcutaneous tumor growth and number of pulmonary metastases more effectively than CPT-11 alone. Conclusion: Radical scavenger, edaravone, blocks CPT-11-induced NF-kB activation, leading to a dramatic augmentation of chemosensitivity and enhanced apoptosis. These results demonstrate that the combination of edaravone with CPT-11 may constitute a new strategy for treating colon cancer and its metastasis.
Efficacy of Venetoclax Based Regimens in Relapsed Refractory Multiple Myeloma: A Systematic Review and Meta-Analysis
Authors: Laila Hashim, Muhammad Salman Faisal, Zahoor Ahmed, Insija Ilyas Selene, Moazzam Shahzad, Syed Maaz Abdullah, Yazan Samhouri, Muhammad Yasir, Ahsan Wahab, Hamid Ehsan, Karun Neupane, Faiz Anwer, Salman Fazal
Journal: Blood (2020)
Myeloma Derived Mitochondrial Damage Associated Molecular Patterns Promote Pro-Tumoral Expansion By Inducing a Pro-Inflammatory Signature in the Bone Marrow Microenvironment
Authors: Aisha Jibril, Jayna J Mistry, Jamie A Moore, Charlotte Hellmich, Victoria Willimott, Kristian M Bowles, Stuart A Rushworth
Journal: Blood (2020)
Hydroxychloroquine in patients with rheumatic diseases during the COVID-19 pandemic: a letter to clinicians
Authors: Karen Schreiber, Savino Sciascia, Ian N Bruce, Ian Giles, Maria J Cuadrado, Hannah Cohen, Caroline Gordon, David Isenberg, Søren Jacobsen, Saskia Middeldorp, Marta Mosca, Sue Pavord, Massimo Radin, Dario Roccatello, Jane Salmon, Evélyne Vinet, Anne Voss, Linda Watkins, Beverley J Hunt
Journal: The Lancet Rheumatology (2020)
The ACE2 Receptor for COVID-19 Entry Is Expressed on the Surface of Hematopoietic Stem/Progenitor Cells and Endothelial Progenitors As Well As Their Precursor Cells and Becomes Activated in Nlrp3 Inflammasome-Dependent Manner By Virus Spike Protein - a Potential Pathway Leading to a "Cytokine Storm"
Authors: Magdalena Kucia, Kamila Bujko, Andrzej Ciechanowicz, Monika Cymer, Katarzyna Sielatycka, Janina Ratajczak, Mariusz Z Ratajczak
Journal: Blood (2020)
Real-World Effectiveness of First-Line (1L) Dasatinib Versus 1L Imatinib in Newly Diagnosed Patients with Chronic Phase Chronic Myeloid Leukemia (CP-CML)
Authors: Andrew J Klink, Scott Justin Keating, John Brokars, Arianna Kee, Ronda Copher, Brian Stwalley, Bruce Feinberg, Elias Jabbour
Journal: Blood (2020)
Molecular Drivers of Onco<i>type</i> DX, Prosigna, EndoPredict, and the Breast Cancer Index: A TransATAC Study
Authors: Richard Buus, Ivana Sestak, Ralf Kronenwett, Sean Ferree, Catherine A. Schnabel, Frederick L. Baehner, Elizabeth A. Mallon, Jack Cuzick, Mitch Dowsett
Journal: Journal of Clinical Oncology (2020)

The Onco
Bioprinting a Multifunctional Bioink to Engineer Clickable 3D Cellular Niches with Tunable Matrix Microenvironmental Cues
Authors: Rúben F. Pereira, Bianca N. Lourenço, Paulo J. Bártolo, Pedro L. Granja
Journal: Advanced Healthcare Materials (2020)

Abstract The properties of the surrounding cell environment are major determinants of cell response in 3D. However, the ability to unravel how these cues dictate the biological function in bioprinted constructs is limited by the lack of extracellular matrix (ECM)‐mimetic bioinks with fully controllable properties. In this study, a multifunctional bioink that uniquely combines the independent control over the biochemical and biophysical cues that regulate cell fate with the bioorthogonal nature of thiol–norbornene photoclick chemistry is designed for the extrusion bioprinting of bioinspired 3D cellular niches with tunable properties. The bioink rheology is controlled by ionic gelation, being dependent on both the type and content of divalent ions (calcium and barium), while the mechanical and biochemical properties of hydrogels are tailored via a post printing thiol–ene reaction. Bioprinted cell‐adhesive and protease‐degradable hydrogels modulate cell proliferation and ECM deposition in a matrix‐stiffness dependent manner over 14 days of culture regardless of cell spreading, demonstrating the ability to probe the effect of matrix cues on cell response. This bioink can be used as a versatile platform where building blocks can be rationally combined for the bioprinting of functional cell‐ and tissue‐specific constructs with controlled cellular behavior.
Abstract 15522: Mathematical Modeling of Right Ventricular Energetics and Efficiency to Enable Discrimination Between NYHA II and III/IV Pulmonary Arterial Hypertension Patients
Authors: Jacqueline V Scott, Tanuf Tembulkar, Bradley Faliks, Kelly Koch, Meng-Lin Lee, Keith Cook
Journal: Circulation (2019)

Introduction: The risk and onset of right ventricular (RV) failure in patients with pulmonary arterial hypertension (PAH) is poorly understood. Hemodynamic variables characterizing RV afterload hav...
Impact of Cardiovascular Disease on Clinical Outcomes in Patients with Acute Myeloid Leukemia and Myelodysplastic Syndrome
Authors: Gabriela Sanchez-Petitto, Olga Goloubeva, James Childress, Tahreem Iqbal, Jack Masur, Max An, Safwan Muhammad, Justin Lawson, Jasmin Sahbaz, Brian Barr, Vu H. Duong, Jennie Y. Law, Ashkan Emadi, Maria R. Baer, Sandrine Niyongere
Journal: Blood (2020)
Misannotated Multi-Nucleotide Variants in Public Cancer Genomics Datasets Lead to Inaccurate Mutation Calls with Significant Implications
Authors: Sujaya Srinivasan, Natallia Kalinava, Rafael Aldana, Zhipan Li, Sjoerd van Hagen, Sander Y.A. Rodenburg, Megan Wind-Rotolo, Xiaozhong Qian, Ariella S. Sasson, Hao Tang, Stefan Kirov
Journal: Cancer Research (2020)

Although next-generation sequencing is widely used in cancer to profile tumors and detect variants, most somatic variant callers used in these pipelines identify variants at the lowest possible granularity, single-nucleotide variants (SNV). As a result, multiple adjacent SNVs are called individually instead of as a multi-nucleotide variants (MNV). With this approach, the amino acid change from the individual SNV within a codon could be different from the amino acid change based on the MNV that results from combining SNV, leading to incorrect conclusions about the downstream effects of the variants. Here, we analyzed 10,383 variant call files (VCF) from the Cancer Genome Atlas (TCGA) and found 12,141 incorrectly annotated MNVs. Analysis of seven commonly mutated genes from 178 studies in cBioPortal revealed that MNVs were consistently missed in 20 of these studies, whereas they were correctly annotated in 15 more recent studies. At the BRAF V600 locus, the most common example of MNV, several public datasets reported separate BRAF V600E and BRAF V600M variants instead of a single merged V600K variant. VCFs from the TCGA Mutect2 caller were used to develop a solution to merge SNV to MNV. Our custom script used the phasing information from the SNV VCF and determined whether SNVs were at the same codon and needed to be merged into MNV before variant annotation. This study shows that institutions performing NGS sequencing for cancer genomics should incorporate the step of merging MNV as a best practice in their pipelines. SIGNIFICANCE: Identification of incorrect mutation calls in TCGA, including clinically relevant BRAF V600 and KRAS G12, will influence research and potentially clinical decisions.
A Phase 2 Study of Odronextamab (REGN1979), a CD20 x CD3 Bispecific Antibody, in Patients with Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma
Authors: Tae Min Kim, Arancha Alonso, Miles Prince, Michal Taszner, Seok-Goo Cho, Don A. Stevens, Michelle Poon, Francesca Lim, Steven Le Gouill, Cecilia Carpio, Mary-Margaret Keating, Lieve Adriaens, Melanie Ufkin, Ayesha Sabir, Jingjin Li, Vladimir Jankovic, Min Zhu, Jurriaan Brouwer-Visser, Siyang Leng, L. Andres Sirulnik, Aafia Chaudhry, Srikanth R. Ambati, Kim Won Seog
Journal: Blood (2020)
The Combination of Tafasitamab and Rituximab Increases Cytotoxicity Against Lymphoma Cells <i>I</i> <i>n Vitro</i>
Authors: Maria Patra, Christian Augsberger, Carmen Ginzel, Andrea Polzer, Karin Landgraf, Dominik Bartel, Daniel Ness, Stefan Steidl, Christina Heitmüller, Juergen Schanzer, Jan Endell
Journal: Blood (2020)
Supervised pulmonary rehabilitation using minimal or specialist exercise equipment in COPD: a propensity-matched analysis
Authors: Suhani Patel, Melanie D Palmer, Claire Marie Nolan, Ruth Emily Barker, Jessica Anne Walsh, Stephanie C Wynne, Sarah Elizabeth Jones, Harriet Shannon, Nicholas S Hopkinson, Samantha Swee Chin Kon, Wei Gao, Matthew Maddocks, William D-C Man
Journal: Thorax (2020)

Background Many trials supporting the benefits of pulmonary rehabilitation (PR) have used specialist exercise equipment, such as treadmills and cycle ergometers. However, access to specialist equipment may not be feasible in some settings. There is growing interest in delivering PR programmes with minimal, low-cost equipment, but uncertainty remains regarding their efficacy compared with programmes using specialist equipment. Methods Using propensity score matching, 318 consecutive patients with COPD undergoing supervised PR using minimal equipment (PR-min) were compared 1:1 with a control group of 318 patients with COPD who underwent supervised PR using specialist equipment (PR-gym). A non-inferiority analysis was performed for the primary outcome (incremental shuttle walk (ISW)) and secondary outcomes (Chronic Respiratory Disease Questionnaire (CRQ)—domain and total scores). Results Similar improvements in ISW and CRQ-domains were observed in PR-min and PR-gym groups (mean difference ISW: 3 m (95% CI −16 to 9); CRQ-total: 0.9 (95% CI −2.7 to 4.5)). The 95% CI between group differences for ISW and CRQ-total did not cross the predefined non-inferiority margins. However, completion rates were lower in PR-min compared with PR-gym (64% vs 73%; p=0.014). Conclusions In patients with COPD, PR delivered using minimal equipment produces clinically significant benefits in exercise capacity and health-related quality of life that are non-inferior to rehabilitation delivered using specialist equipment. This study provides support for the provision of PR using minimal exercise equipment, particularly in areas where access to specialist exercise equipment is limited.
COVID-19–Associated Hospitalizations Among Health Care Personnel — COVID-NET, 13 States, March 1–May 31, 2020
Authors: Anita K. Kambhampati, Alissa C. O’Halloran, Michael Whitaker, Shelley S. Magill, Nora Chea, Shua J. Chai, Pam Daily Kirley, Rachel K. Herlihy, Breanna Kawasaki, James Meek, Kimberly Yousey-Hindes, Evan J. Anderson, Kyle P. Openo, Maya L. Monroe, Patricia A. Ryan, Sue Kim, Libby Reeg, Kathryn Como-Sabetti, Richard Danila, Sarah Shrum Davis, Salina Torres, Grant Barney, Nancy L. Spina, Nancy M. Bennett, Christina B. Felsen, Laurie M. Billing, Jessica Shiltz, Melissa Sutton, Nicole West, William Schaffner, H. Keipp Talbot, Ryan Chatelain, Mary Hill, Lynnette Brammer, Alicia M. Fry, Aron J. Hall, Jonathan M. Wortham, Shikha Garg, Lindsay Kim, Nisha B. Alden, Kathy M. Angeles, Mirasol Apostol, David Blythe, Alicia Brooks, Susan Brooks, Sophrena Bushey, Erica Bye, Melissa Christian, Ashley Coates, Elizabeth Dufort, Nancy Eisenberg, Linda Frank, Maria Gaitan, Andrea George, Caroline Habrun, Emily B. Hancock, Brooke Heidenga, Kareena Hundal, Sarah A. Khanlian, RaeAnne Kurtz, Ruth Lynfield, Tiffanie Markus, Laine McCullough, Seth Meador, Alison Muse, Joelle Nadle, Meaghan Novi, Jake Ortega, Ama Owusu-Dommey, Rachel D. Park, Alexandra M. Piasecki, Andrea Price, Sherry Quach, Jeremy Roland, Maria Rosales, Yadira Salazar-Sanchez, Melanie Spencer, Ashley Swain, Michelle W. Wilson
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

Health care personnel (HCP) can be exposed to SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), both within and outside the workplace, increasing their risk for infection. Among 6,760 adults hospitalized during March 1-May 31, 2020, for whom HCP status was determined by the COVID-19-Associated Hospitalization Surveillance Network (COVID-NET), 5.9% were HCP. Nursing-related occupations (36.3%) represented the largest proportion of HCP hospitalized with COVID-19. Median age of hospitalized HCP was 49 years, and 89.8% had at least one underlying medical condition, of which obesity was most commonly reported (72.5%). A substantial proportion of HCP with COVID-19 had indicators of severe disease: 27.5% were admitted to an intensive care unit (ICU), 15.8% required invasive mechanical ventilation, and 4.2% died during hospitalization. HCP can have severe COVID-19-associated illness, highlighting the need for continued infection prevention and control in health care settings as well as community mitigation efforts to reduce transmission.
Predicting Early Hepatic Graft Failure—The Quest Continues
Authors: Ronald W. Busuttil
Journal: JAMA Surgery (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Carfilzomib 56mg/m2 Twice-Weekly in Combination with Dexamethasone and Daratumumab (KdD) Versus Daratumumab in Combination with 8 Cycles of Bortezomib and Dexamethasone (DVd); A Matching-Adjusted Indirect Treatment Comparison
Authors: Katja Weisel, Ajay Nooka, Evangelos Terpos, Andrew Spencer, Hartmut Goldschmidt, Istvan Majer, Lucy DeCosta, Rohan Medhekar, Akeem Yusuf, Shaji K. Kumar
Journal: Blood (2020)
The Role of PET-MRI in Multiple Myeloma Patients
Authors: Laurent Garderet, Driss Kharroubi-Lakouas, Damien roos Weil, Nathalie Jacque, Maya Ouzegdouh Ouarab, Suella Martino, Veronique Morel, Adrien Grenier, Choquet Sylvain, Veronique Leblond, Aurelie Kas, Olivier Lucidarme
Journal: Blood (2020)
Towards Identifying the Target of Autoimmunity in Aplastic Anemia
Authors: Benjamin F Frost, Jamie Duke, Hongbo Xie, Deborah Ferriola, Joseph H Oved, Peter Nicholas, Jian-Meng Fan, Ryan Hausler, Alison A. Bertuch, Elissa M. Furutani, Akiko Shimamura, Stephanie J. Lee, Stephen R. Spellman, Dimitri S. Monos, Timothy S. Olson, Daria V. Babushok
Journal: Blood (2020)
Quantification of Chimerism and Graft Immune Cell Composition with Alloseq HCT, a Highly Sensitive and Precise Next-Generation Sequencing Assay, in Patients Post-Hematopoietic Stem Cell Transplantation
Authors: Zuleika Calderin-Sollet, Paul Kyle, Silvia Casas, Marica Grskovic, Thierry Viard, Jean Villard
Journal: Blood (2020)
Decision Making Factors That Influence Treatment Options for an Autologous Stem Cell Transplant for Older Adults (aged 65-75) with Newly Diagnosed Multiple Myeloma: A Mixed Methods Study
Authors: Owais Mian, Martine Puts, Arleigh McCurdy, Tanya M. Wildes, Mark A Fiala, Matthew Kang, Mary Salib, Shabbir Alibhai, Hira S Mian
Journal: Blood (2020)
35 Learning to take control
Authors: E Wallace, L Croxon, K Lennon, E Smith
Journal: Gut (2017)

Background  Bowel care is a complex process, often a taboo subject. It is difficult to source a visual explanation tool for the teaching of the practical aspects of neurogenic bowel dysfunction for spinal cord individuals.  Aim  To develop in a scientific manner an animation training video showing the following procedures: Insertion of a rectal suppository, Digital Rectal Stimulation and Digital Removal of Faeces.  This animation is a visual step by step approach, structuralising the education required for individuals with a neurogenic bowel dysfunction. It also supports their carers, families and health care professionals. Visual media will help to organise, process and retain information for the learner.  Method  Kick off and research included compiling an interdisciplinary steering group. Relevant information was collected for the animation video including reviewing guidelines/articles/relevant bowel videos, etc. The driver diagram was used to plan the project along with the PDSA cycle (plan, do, study, act). Funding was obtained and animators were briefed on the project.  Results  This animation DVD will augment the learning experience, by integrating technology and modernising our training for an enriched learning experience.  Overall results showed that 90% found the animation video excellent and suitable for both individuals with a spinal cord injury and health care professionals.  Conclusions  The animation training video is not a standalone teaching tool, but will assist in providing relevant information. It will support training effectiveness for both skills and knowledge, using evidence based practice.
Pre-Clinical Combination of AO-176, a Highly Differentiated Clinical Stage CD47 Antibody, with Either Azacitidine or Venetoclax Significantly Enhances DAMP Induction and Phagocytosis of Acute Myeloid Leukemia
Authors: Mike J Donio, W. Casey Wilson, Isra Darwech, Gabriela Andrejeva, Benjamin J Capoccia, Robyn J Puro, Arun K Kashyap, Daniel S Pereira
Journal: Blood (2020)
Feasibility of the deep learning method for estimating the ventilatory threshold with electrocardiography data
Authors: Kotaro Miura, Shinichi Goto, Yoshinori Katsumata, Hidehiko Ikura, Yasuyuki Shiraishi, Kazuki Sato, Keiichi Fukuda
Journal: npj Digital Medicine (2020)

Regular aerobic physical activity is of utmost importance in maintaining a good health status and preventing cardiovascular diseases (CVDs). Although cardiopulmonary exercise testing (CPX) is an essential examination for noninvasive estimation of ventilatory threshold (VT), defined as the clinically equivalent to aerobic exercise, its evaluation requires an expensive respiratory gas analyzer and expertize. To address these inconveniences, this study investigated the feasibility of a deep learning (DL) algorithm with single-lead electrocardiography (ECG) for estimating the aerobic exercise threshold. Two hundred sixty consecutive patients with CVDs who underwent CPX were analyzed. Single-lead ECG data were stored as time-series voltage data with a sampling rate of 1000 Hz. The data of preprocessed ECG and time point at VT calculated by respiratory gas analyzer were used to train a neural network. The trained model was applied on an independent test cohort, and the DL threshold (DLT; a time of VT estimated through the DL algorithm) was calculated. We compared the correlation between oxygen uptake of the VT (VT-VO2) and the DLT (DLT-VO2). Our DL model showed that the DLT-VO2 was confirmed to be significantly correlated with the VT-VO2 (r = 0.875; P < 0.001), and the mean difference was nonsignificant (-0.05 ml/kg/min, P > 0.05), which displayed strong agreements between the VT and the DLT. The DL algorithm using single-lead ECG data enabled accurate estimation of VT in patients with CVDs. The DL algorithm may be a novel way for estimating aerobic exercise threshold.