tbuckley/cabot-search huggingface dataset:
Dominant role of in situ native cartilage niche for determining the cartilage type regenerated by BMSCs
Authors: Mengjie Hou, Baoxing Tian, Baoshuai Bai, Zheng Ci, Yu Liu, Yixin Zhang, Guangdong Zhou, Yilin Cao
Journal: Bioactive Materials (2021)

Tissue-engineered cartilage regeneration by bone marrow stromal cells (BMSCs) is considered an ideal method. However, how to regulate BMSCs to regenerate specific types of cartilage remains unclear, which significantly limits its clinical translation and leads to suboptimal clinical effects. Herein, we systematically explored the role of native ear and articular cartilage niches on the differentiation fate of BMSCs and the type of regenerated cartilage. First, we prepared two types of acellular cartilage sheets (ACSs) and two types of chondrocytes. Then green fluorescent protein-labeled BMSCs were seeded on two types of ACSs with or without corresponding types of chondrocytes using a sandwich model and directed or cross-implanted them into native cartilage niches. After one year of in vivo culture, cell tracking and the results of histological results showed that the native cartilage niches were capable of regulating BMSCs regeneration into specific types of cartilage that were consistent with the cartilage types of the implanted sites. Furthermore, even when the type of niche formed by ACSs or the biomimetic cartilage niche constructed by specific types of ACSs and specific types of chondrocytes did not match with the native cartilage niche, the native cartilage niche continued to determine the type of cartilage regenerated by implanted BMSCs and chondrocytes. All our results provide sufficient evidence for specific types of cartilage regeneration using chondrogenic potential cells, such as mesenchymal stem cells and chondrocytes.
Safety and Efficacy of Third Generation CD20 Targeted CAR-T (MB-106) for Treatment of Relapsed/Refractory B-NHL and CLL
Authors: Mazyar Shadman, Cecilia Yeung, Mary Redman, Sang Yun Lee, Dong Hoon Lee, Susan Ra, Chaitra S. Ujjani, Bruce J. Dezube, Christina Poh, Edus H. Warren, Aude G. Chapuis, Damian J. Green, Andrew J. Cowan, Ryan D. Cassaday, Hans-Peter Kiem, Jordan Gauthier, Cameron J. Turtle, Ryan C. Lynch, Stephen D. Smith, Ajay K Gopal, David G. Maloney, Brian G. Till
Journal: Blood (2021)
The Histone Demethylase KDM6B Is a Genetic Dependency of NOTCH1-Driven T-ALL
Authors: Nancy Issa, Hamza Celik, Hassan Bjeije, Wangisa M.B. Dunuwille, Won Kyun Koh, Tyler Parsons, Christine R Zhang, Wentao Han, Grant A. Challen
Journal: Blood (2021)
Hypoxic Storage of Red Blood Cells: Assessment of Adhesion Properties Using a Standardized Endothelium-on-a-Chip Microfluidic Platform
Authors: Erdem Kucukal, Aaron Wolfe, Ryan Kocevar, Lalitha V Nayak, Samuel Sowemimo-Coker, John Zak, Laurel Omert, Umut A. Gurkan
Journal: Blood (2021)
Development of Proteolytic Targeting Chimeras to Target Lck in T-Cell Acute Lymphoblastic Leukemia
Authors: Jianzhong Hu, Jamie Jarusiewicz, Jaeki Min, Lei Yang, Divyabharathi Chepyala, Marisa Actis, Lauren Rowland, Guoqing Du, Brandon Smart, Dylan Maxwell, Boer Xie, Satoshi Yoshimura, Junmin Peng, David Teachey, Zoran Rankovic, Jun J. Yang
Journal: Blood (2021)
Lateral Flow Glyco‐Assays for the Rapid and Low‐Cost Detection of Lectins–Polymeric Linkers and Particle Engineering Are Essential for Selectivity and Performance
Authors: Alexander N. Baker, Asier R. Muguruza, Sarah‐Jane Richards, Panagiotis G. Georgiou, Stephen Goetz, Marc Walker, Simone Dedola, Robert A. Field, Matthew I. Gibson
Journal: Advanced Healthcare Materials (2021)

Lateral flow immuno-assays, such as the home pregnancy test, are rapid point-of-care diagnostics that use antibody-coated nanoparticles to bind antigens/analytes (e.g., viruses, toxins or hormones). Ease of use, no need for centralized infrastructure and low-cost, makes these devices appealing for rapid disease identification, especially in low-resource environments. Here glycosylated polymer-coated nanoparticles are demonstrated for the sensitive, label-free detection of lectins in lateral flow and flow-through. The systems introduced here use glycans, not antibodies, to provide recognition: a "lateral flow glyco-assay," providing unique biosensing opportunities. Glycans are installed onto polymer termini and immobilized onto gold nanoparticles, providing colloidal stability but crucially also introducing assay tunability and selectivity. Using soybean agglutinin and Ricinus communis agglutinin I (RCA
Maximal Tolerated Dose Determined for Venetoclax in Combination with Liposomal Vincristine in Patients with Relapsed or Refractory Ph-Negative T-Cell or B-Cell Acute Lymphoblastic Leukemia: Results of Phase 1 Portion of ECOG-ACRIN EA9152
Authors: Neil Palmisiano, Ju-Whei Lee, David F. Claxton, Elisabeth Paietta, Hassan B. Alkhateeb, Jae H Park, Nikolai Podoltsev, Ehab L. Atallah, Dale G Schaar, Shira Dinner, Jonathan Webster, Selina M. Luger, Mark R. Litzow
Journal: Blood (2021)
Abstract 16323: Short Lasting Exhaustive High-Intensity Intermittent Exercise Reduces Arterial Stiffness Through Enhancement of Aortic No Bioavailability
Authors: Natsuki Hasegawa, Shumpei Fujie, Naoki Horii, Eri Miyamoto-Mikami, Katsunori Tsuji, Masataka Uchida, Takafumi Hamaoka, Izumi Tabata, Motoyuki Iemitsu
Journal: Circulation (2017)

Introduction: Moderate-intensity continuous training (MICT) reduces arterial stiffness. Recent studies have showed the reducing effect of high-intensity intermittent exercise training (HIIT) on art...
An integrative understanding of the large metabolic shifts induced by antibiotics in critical illness
Authors: Andrea Marfil-Sánchez, Lu Zhang, Pol Alonso-Pernas, Mohammad Mirhakkak, Melinda Mueller, Bastian Seelbinder, Yueqiong Ni, Rakesh Santhanam, Anne Busch, Christine Beemelmanns, Maria Ermolaeva, Michael Bauer, Gianni Panagiotou
Journal: Gut Microbes (2021)

Antibiotics are commonly used in the Intensive Care Unit (ICU); however, several studies showed that the impact of antibiotics to prevent infection, multi-organ failure, and death in the ICU is less clear than their benefit on course of infection in the absence of organ dysfunction. We characterized here the compositional and metabolic changes of the gut microbiome induced by critical illness and antibiotics in a cohort of 75 individuals in conjunction with 2,180 gut microbiome samples representing 16 different diseases. We revealed an "infection-vulnerable" gut microbiome environment present only in critically ill treated with antibiotics (ICU+). Feeding of Caenorhabditis elegans with Bifidobacterium animalis and Lactobacillus crispatus, species that expanded in ICU+ patients, revealed a significant negative impact of these microbes on host viability and developmental homeostasis. These results suggest that antibiotic administration can dramatically impact essential functional activities in the gut related to immune responses more than critical illness itself, which might explain in part untoward effects of antibiotics in the critically ill.
Characterization and Management of Oral and Dermatological Toxicities in Patients Receiving the CD3 X GPRC5D Bispecific Antibody Talquetamab (JNJ-64407564) for the Treatment of Relapsed and/or Refractory Multiple Myeloma
Authors: Stefania Stefania Mancia, Annamaria Farrell, Karen Louw, Erika Florendo, Elizabeth Aronson, Kiah Purcell, Donna D Catamero, Juliet Escalon, Joanne Thomas, Annel Aponte, Angela Lamb, Diana Kirke, Aimee Lucas, Sundar Jagannath, Hearn Jay Cho, Samir Parekh, Joshua Richter, Larysa Sanchez, Ajai Chari
Journal: Blood (2021)
Abstract 9053: ASIC3 Knockout Alleviates Exaggerated Blood Pressure Response Induced by P2X3 Activation in Hindlimb Muscle Afferent Nerves of Rats With Experimental Peripheral Artery Disease
Authors: Lu Qin, Qin Li, Jianhua Li
Journal: Circulation (2021)

Background: In peripheral artery disease (PAD), the metaboreceptor and mechanoreceptor in muscle afferent nerves contribute to accentuated sympathetic outflow via a neural reflex. Particularly, lactic acid and ATP produced in exercising muscles respectively stimulate acid sensing ion channel subtype 3 (ASIC3) and purinergic subunit P2X3 receptors in muscle afferent nerves, inducing the reflex sympathetic and arterial blood pressure responses during exercise. Methods: We examined that the P2X3 protein expression in the dorsal root ganglion (DRG) and P2X currents in DRG neurons using western blotting and patch-clamp methods, and the pressor response to P2X3 stimulation using the whole animal preparations. Four groups were included: 1. Wild type (WT) rats; 2. ASIC3 knockout (KO) rats; 3. WT-PAD rats with three days of femoral artery occlusion; 4. KO-PAD rats with three days of femoral artery occlusion. Results: First, P2X3 expression was significantly increased in KO rats compared with that in WT rats (optical density: 6.51±2.20/n=5; P &lt;0.05 vs. WT). However, the levels of P2X3 expression were not significantly increased in KO-PAD rats compared with the KO rats (optical density: 7.99±1.99/n=6; P &gt;0.05 vs. KO) . Second, in WT rats, as 10, 30 and 50 μM of αβ-me ATP (P2X3 agonist) were applied, peak amplitude of both transient and sustained P2X currents was increased by femoral artery occlusion (all P &lt;0.05 WT-PAD vs. WT). Insignificant differences in both transient and sustained P2X currents were found between KO rats and KO-PAD rats (all P &gt;0.05 vs. KO) when αβ-me ATP was applied except of the transient P2X current amplitude at 50 μM of αβ-me ATP. Third, there were insignificant differences in the mean arterial pressure response to 0.0625, 0.125 and 0.25 mM of αβ-me ATP injected into the hindlimb circulation between KO rats and KO-PAD rats (all P &gt;0.05 vs. KO). Conclusions: Compared with WT rats, augmented P2X3-mediated pressor response is blunted by ASIC3 KO in PAD rats and this is accompanied with downregulated P2X3 expression and suppressed activities in P2X3 signaling pathways in muscle afferent neurons.
Abstract 9169: A Non-Invasive Virtual Heart Approach Predicts Reentrant Ventricular Arrythmia (VA) Circuits in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC): A Proof-of-Concept Study
Authors: Yingnan Zhang, Adityo Prakosa, Pallavi Pandey, Stefan L Zimmerman, Harikrishna Tandri, Cynthia A James, Crystal Tichnell, Brittney Murray, Hugh Calkins, Natalia Trayanova
Journal: Circulation (2021)

Introduction: ARVC is a leading inherited cause of VA in young adults. Progressive and extensive structural and electrical remodeling in the right ventricle (RV) serves as a complex substrate for reentrant VA circuits in ARVC. Non-invasive prediction of ARVC reentrant VA circuits could provide a thorough pre-ablation evaluation of the arrhythmogenic substrate and identify specific region(s) to target during the ablation procedure. Here we developed a non-invasive personalized virtual heart approach that accurately predicts reentrant VA circuits in ARVC patients. Methods: As a proof-of-concept retrospective study, we constructed 3D computational models of ARVC patients’ hearts from LGE-CMR scans with observed RV hyperenhancements representing arrhythmogenic substrates (Fig A). 3 patients were included in this study: patient 1 (P1) had clinical VA and inducibility in electrophysiologic study (EPS); patient 2 (P2) had negative EPS despite previous evidence of VA; patient 3 had no VA. We generated a computational model for each heart incorporating personalized diffuse and dense (scar) fibrosis distribution. ARVC-specific ionic and conduction properties were represented in different regions. The VA inducibility of each model was assessed by rapid pacing from 9 RV sites. Results: For all cases, model outcomes correlated with clinical observations. In P1 model, VA was induced from the inferior basal region, as observed in EPS. Reentrant wavefronts occurred endocardially near the patient’s scar region, matching the EPS (Fig C1). Clinical ablation at this location terminated VA. In P2, VA was induced by pacing from the inferior lateral wall, a pacing location not part of the EPS protocol; reentry occurred on the basal lateral wall (Fig C2), a common location for VA circuits in ARVC. No VA was induced in P3. Conclusions: The novel ARVC virtual heart approach accurately predicts reentrant VA circuits and can potentially become a tool in assisting ablation in ARVC patients.
Immunotherapy Targeting ST2/IL-33 Signaling in Myeloid Leukemia Stem Cells
Authors: Denggang Fu, Hua Jiang, Alan Long, Hong fen Guo, Maegan L. Capitano, Baskar Ramdas, Reuben Kapur, Nai-Kong V. Cheung, Sophie Paczesny
Journal: Blood (2021)
Single-Cell and Spatial Analyses Characterize Distinct Subsets of Malignant T Cells in Angioimmunoblastic T Cell Lymphoma
Authors: Francois Lemonnier, Chuang Dong, Bruno Tesson, Laurine Gil, Noudjoud Attaf, Diana-Laure Mboumba, Philippe Gaulard, Pierre Milpied
Journal: Blood (2021)
作動薬抗CD137 mAbは腫瘍内皮細胞に作用し,活性Tリンパ球の局所化を強める
Authors: Palazon Asis, Teijeira Alvaro, Martinez-Forero Ivan, Hervas-Stubbs Sandra, Roncal Carmen, Penuelas Ivan, Dubrot Juan, Morales-Kastresana Aizea, Perez-Gracia Jose Luis, Ochoa M. Carmen, Ochoa-Callejero Laura, Martinez Alfredo, Luque Alfonso, Dinchuk Joseph, Rouzaut Ana, Jure-Kunkel Maria, Melero Ignacio
Journal: Cancer Research (2011)
Myeloablative Fractionated Busulfan Conditioning Regimen with Venetoclax in Patients with AML/MDS: Prospective Phase II Clinical Trial
Authors: Uday R. Popat, Rohtesh S. Mehta, Roland Bassett, Amin M. Alousi, Gheath Alatrash, Qaiser Bashir, Chitra Hosing, Jin S. Im, Partow Kebriaei, Alison Gulbis, David Marin, Yago Nieto, Amanda L. Olson, Betul Oran, Jeremy L. Ramdial, Neeraj Saini, Samer A. Srour, Benigno C. Valdez, Katayoun Rezvani, Muzaffar H. Qazilbash, Tapan M. Kadia, Marina Konopleva, Elizabeth J. Shpall, Borje S. Andersson, Richard E. Champlin
Journal: Blood (2021)
Large β Globin Gene Cluster Deletions and Implications on Transcription Factor Regulation in Hemoglobin Switching - Α Novel ε Gγ Αγ Deletion with Intact LCR
Authors: Christineil Thompson, Mira A Kohorst, Aruna Rangan, Jessica M Bortnova, Tavanna R Porter, Phuong L Nguyen, Eric D Wieben, Linda Hasadsri, James D Hoyer, Jennifer L Oliveira
Journal: Blood (2021)
Abstract PO-090: TGF-β induced EMT gene expression is associated with promoter demethylation in pancreatic cancer
Authors: Manjul Rana, Abul Elahi, Abidemi O. Ajidahun, Rita G. Kansal, Anders E. Berglund, David Shibata, Evan S. Glazer
Journal: Cancer Research (2021)

Abstract INTRODUCTION: Transforming growth factor-β (TGF-β), a ubiquitous molecule in pancreatic ductal adenocarcinoma (PDA) tumors, acts as a potent inducer of tumor invasion by regulating proteins involved in metastasis and driving epithelial-mesenchymal transition (EMT). We hypothesized that TGF-β signaling-induced EMT is regulated by DNA methylation. To evaluate this, we investigated the association between EMT gene promoter methylation status and gene expression in the TCGA PDA dataset. We also investigated vimentin gene (a mesenchymal marker)-specific changes in DNA methylation due to TGF-β treatment in PDA cells. METHODS: The methylation status of EMT-related genes (ZEB2, CDH2, Vimentin) was interrogated in the TCGA PDA data set. β-values (proportion of methylated gene probes in a location) were compared to gene expression levels. Next, a PDA cell line (Panc-1) was treated with TGF-β (10ng/ml), vehicle control, DNA methyltransferase inhibitor (5-azacytidine, AZA, 10mM), or TGF-β plus AZA to evaluate the effects on the DNA methylation status of the vimentin gene with methylation-specific PCR (MSP) against the promoter region of vimentin. Unmethylation and methylation levels at the vimentin promoter region were then compared. RESULTS: We found that β values of promotor regions of ZEB2, CDH2, and Vimentin were moderately negatively correlated with gene expression (Pearson r varies from 0.45 to 0.63) in the PDA TCGA data set. In Panc-1 cells, vimentin gene expression was increased following treatment with AZA compared to controls suggesting that DNA demethylation increases vimentin gene expression. MSP demonstrated that TGF-β treatment increased unmethylated vimentin gene levels compared to vehicle control treatment. TGF-β treatment increased unmethylated vimentin gene levels more so than methylated gene levels. CONCLUSIONS: These results demonstrate that gene expression of EMT-related genes may be at least partially regulated by DNA methylation. We demonstrate that TGF-β treatment leads to increased Vimentin promotor demethylation (lower β value) and increased gene expression in Panc-1 cells. This observation is consistent with our findings in the TCGA data set that lower β-values are associated with increased expression of mesenchymal genes, indicative of EMT. Further studies are underway to investigate the relationship between DNA methylation and TGF-β-induced EMT in general. Citation Format: Manjul Rana, Abul Elahi, Abidemi O. Ajidahun, Rita G. Kansal, Anders E. Berglund, David Shibata, Evan S. Glazer. TGF-β induced EMT gene expression is associated with promoter demethylation in pancreatic cancer [abstract]. In: Proceedings of the AACR Virtual Special Conference on Pancreatic Cancer; 2021 Sep 29-30. Philadelphia (PA): AACR; Cancer Res 2021;81(22 Suppl):Abstract nr PO-090.
Glucose-Insulin-Potassium Infusion and Mortality in the CREATE-ECLA Trial
Authors: Jayant Dey, Lawrence Blonde, Alan Burshell, Peggy Bolton, Anita Richard
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Utilizing Clinical Features of Progression to Predict Richter's Syndrome in Patients with CLL Progressing after Ibrutinib
Authors: Adam S Kittai, Ying Huang, Ashleigh Keiter, Kyle A Beckwith, Daniel Goldstein, Seema A Bhat, David A. Bond, John C. Byrd, Michael R Grever, Kerry A Rogers, Jennifer A. Woyach
Journal: Blood (2021)
SAT0374 Radiofrequency kyphoplasty versus conservative care: Results of treating vertebral body fractures
Authors: R. Pflugmacher, R. Bornemann, T. Karius, L.A. Otten, D.C. Wirtz
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> There is controversy about how to treat vertebral fractures. Conservative care is the default approach, despite lack of evidence. Radiofrequency kyphoplasty uses ultrahigh viscosity cement to restore spinal posture and stabilize the fracture. <h3>Objectives</h3> The aims of this study were to compare radiofrequency kyphoplasty to conservative care and assess the usual algorithm of starting all patients on conservative care for 6 weeks before offering surgery. <h3>Methods</h3> Elderly patients with painful osteoporotic vertebral compression fractures were all treated with 6 weeks of conservative care (analgesics, bracing, and physiotherapy). They were then offered the choice of continuing conservative care or crossing over to radiofrequency kyphoplasty, at 6 and 12 weeks. Clinical success was defined as: 1) VAS pain improvement ≥2, 2) final VAS pain ≤5, 3) no functional worsening on ODI. <h3>Results</h3> After the initial 6 weeks of conservative care, only 1 of 65 patients met the criteria for clinical success, and median VAS improvement was 0. After 12 weeks of conservative care, only 5 of 38 patients met the criteria for clinical success, and median VAS improvement was 1. At the 6 week follow-up after radiofrequency kyphoplasty, 31 of 33 surgery patients met the criteria for clinical success, and median VAS improvement was 5. <h3>Conclusions</h3> For the vast majority of patients, conservative care did not provide meaningful clinical improvement. By contrast, nearly all patients who underwent radiofrequency kyphoplasty had rapid substantial improvement. Surgery was clearly much more effective than conservative care and should be offered to patients much sooner. <h3>Disclosure of Interest</h3> None Declared
Pparα Ablation Suppresses T Cell Responses and Anti-Tumor Immunity By Compromising the Antigen-Presenting Properties of Tumor-Associated Macrophages
Authors: Anthos Christofides, Carol Cao, Qi Wang, Natalia M Tijaro-Ovalle, Eirini Konstantinidou, Rushil Shah, Chinmay Jani, Rinku Pal, Halil-Ibrahim Aksoylar, Nikolaos Patsoukis, Vassiliki A Boussiotis
Journal: Blood (2021)
A Global Phase 2 Study of Valemetostat Tosylate (Valemetostat) in Patients with Relapsed or Refractory (R/R) Peripheral T-Cell Lymphoma (PTCL), Including R/R Adult T-Cell Leukemia/Lymphoma (ATL) - Valentine-PTCL01
Authors: Francine M. Foss, Pierluigi Porcu, Steven M. Horwitz, Koji Izutsu, Kenji Ishitsuka, Kazunobu Kato, Jin Jin, Yining Du, Ai Inoue
Journal: Blood (2021)
Clinical and Biological Characterization of Low Risk MDS Patients According to Ring Sideroblasts (RS). Comparison between the 3 Subgroups in WHO2017 Classification. Study from the Spanish MDS Registry
Authors: Félix López Cadenas, Teresa Bernal del Castillo, Guillermo Sanz, Montserrat Arnan Sangerman, Fernando Ramos, Carme Pedro, Mar Tormo, Maria T Ardanaz, Ana Vicente, Gema Azaceta Reinares, Carlos Fernández, Asunción Mora Casado, Alba Redondo Guijo, Maria Vahi, Carlos Aguilar, Ángeles Medina Perez, Yapci Ramos de León, Laura Vicente, David Valcárcel, Maria Diez-Campelo
Journal: Blood (2021)
BMA condemns failure to stop sending mental health patients long way for treatment
Authors: Gareth Iacobucci
Journal: BMJ (2021)

The government has failed to meet its promise to stop the harmful practice of sending mentally unwell patients far from their own home for their care, the BMA has warned.

Latest figures published by NHS England on 11 November show that 1260 new patients had been inappropriately sent for inpatient care many miles from their homes in the three months to August 2021.1

This was despite a pledge to end the practice by April 2021.2

The BMA, which warned back in 2017 that the practice was “endemic,”3 noted that NHS England was not on track to meet the target even before the covid pandemic, with the number of …
16p Deletion Involving BCMA Locus Is Frequent and Predominantly Observed with del17p
Authors: Mehmet K. Samur, Anil Aktas-Samur, Romain Lannes, Jill Corre, Anjan Thakurta, Kenneth C. Anderson, Herve Avet-Loiseau, Nikhil C. Munshi
Journal: Blood (2021)
An Interim Report on a Phase 1/2 Study of HPN217, a Half-Life Extended Tri-Specific T Cell Activating Construct (TriTAC ®) Targeting B Cell Maturation Antigen for the Treatment of Relapsed/Refractory Multiple Myeloma
Authors: Sumit Madan, Al-Ola Abdallah, Andrew J. Cowan, William I. Bensinger, Jens Hillengass, Xavier Leleu, Eva Medvedova, Caitlin Costello, Brea Lipe, Henning Schade, Rajneesh Nath, Liping Laura Sun
Journal: Blood (2021)
High-Dose Bendamustine, Etoposide, Cytarabine and Melphalan (BeEAM) Conditioning Prior to Autologous Transplantation for Patients with Multiple Myeloma: Results of a Prospective Phase II Trial
Authors: Scott R. Solomon, Melhem Solh, Stacey Brown, Nancy Shegda, Katelin C Jackson, Xu Zhang, Lawrence E Morris, Asad Bashey, H. Kent Holland
Journal: Blood (2021)