tbuckley/cabot-search huggingface dataset:
IMPACT OF ACTIVE HEMATOLOGIC MALIGNANCIES ON CLINICAL OUTCOMES IN PATIENTS HOSPITALIZED WITH ATRIAL TACHYARRHYTHMIAS
Authors: Satyam Krishan, Ramtej Atluri, Muhammad Khan, Sreeram Yalamanchili, Omar Khdeir, Bilal Munir, Abhishek Deshmukh, Zain Ul Abideen Asad
Journal: Journal of the American College of Cardiology (2022)
A deep learning-based system for real-time image reporting during esophagogastroduodenoscopy: a multicenter study
Authors: Zehua Dong, Lianlian Wu, Ganggang Mu, Wei Zhou, Yanxia Li, Zhaohong Shi, Xia Tian, Song Liu, Qingxi Zhu, Renduo Shang, Mengjiao Zhang, Lihui Zhang, Ming Xu, Yijie Zhu, Xiao Tao, Tingting Chen, Xun Li, Chenxia Zhang, Xinqi He, Jing Wang, Renquan Luo, Hongliu Du, Yutong Bai, Liping Ye, Honggang Yu
Journal: Endoscopy (2022)

Endoscopic reports are essential for the diagnosis and follow-up of gastrointestinal diseases. This study aimed to construct an intelligent system for automatic photo documentation during esophagogastroduodenoscopy (EGD) and test its utility in clinical practice.Seven convolutional neural networks trained and tested using 210,198 images were integrated to construct the endoscopic automatic image reporting system (EAIRS). We tested its performance through man-machine comparison at three levels: internal, external, and prospective test. Between May 2021 and June 2021, patients undergoing EGD at Renmin Hospital of Wuhan University were recruited. The primary outcomes were accuracy for capturing anatomical landmarks, completeness for capturing anatomical landmarks, and detected lesions.The EAIRS outperformed endoscopists in retrospective internal and external test. A total of 161 consecutive patients were enrolled in the prospective test. The EAIRS achieved an accuracy of 95.2% in capturing anatomical landmarks in the prospective test. It also achieved higher completeness on capturing anatomical landmarks compared with endoscopists: (93.1% vs. 88.8%), and was comparable to endoscopists on capturing detected lesions: (99.0% vs. 98.0%).The EAIRS can generate qualified image reports and could be a powerful tool for generating endoscopic reports in clinical practice.
Corrigendum to: ‘A genetic risk score and diabetes predict development of alcohol-related cirrhosis in drinkers’ [J Hepatol 2022 (76) 275–282]
Authors: John B. Whitfield, Tae-Hwi Schwantes-An, Rebecca Darlay, Guruprasad P. Aithal, Stephen R. Atkinson, Ramon Bataller, Greg Botwin, Naga P. Chalasani, Heather J. Cordell, Ann K. Daly, Christopher P. Day, Florian Eyer, Tatiana Foroud, Dermot Gleeson, David Goldman, Paul S. Haber, Jean-Marc Jacquet, Tiebing Liang, Suthat Liangpunsakul, Steven Masson, Philippe Mathurin, Romain Moirand, Andrew McQuillin, Christophe Moreno, Marsha Y. Morgan, Sebastian Mueller, Beat Müllhaupt, Laura E. Nagy, Pierre Nahon, Bertrand Nalpas, Sylvie Naveau, Pascal Perney, Munir Pirmohamed, Helmut K. Seitz, Michael Soyka, Felix Stickel, Andrew Thompson, Mark R. Thursz, Eric Trépo, Timothy R. Morgan, Devanshi Seth
Journal: Journal of Hepatology (2022)
RARE CASE OF MYOCARDIAL INFARCTION CAUSED BY PSEUDOANEURYSM OF THE LEFT VENTRICULAR OUTFLOW TRACT COMPRESSING THE LEFT ANTERIOR DESCENDING ARTERY
Authors: Rupinder Buttar, Devesh Rai, Ritambhara Pandey, Shaweta Khosa, Salman Zahid, Samarthkumar Thakkar, Khosa Gurveer, Mohan Rao, Bipul Baibhav, Scott Feitell
Journal: Journal of the American College of Cardiology (2022)
The 13th International Oncolytic Virus Conference: Powerful payloads gain clinical momentum
Authors: Shruthi Naik, Luke Russell
Journal: Molecular Therapy (2022)

The 13th International Oncolytic virus conference (IOVC#13) was held November 5–7, 2021, during the “false spring” between the Delta and Omicron phases of the coronavirus disease 2019 (COVID-19) pandemic. IOVC#13 was organized as a hybrid meeting with approximately 90 attendees gathering in person surrounded by the red rocks of Sedona, Arizona and more than 240 attending virtually from around the world. We are grateful to the intrepid organizers, including the American Society of Gene and Cell Therapy (ASGCT) team led by David Barrett and Kah Whye Peng, with Stephen Russell as her first assistant (Mayo Clinic/Vyriad), who took on the challenge of putting together a seamless experience for in-person and virtual attendees.
Use of adherence monitoring in drug contracts tied to outcomes: put patients first
Authors: Theodore Bartholomew, Huseyin Naci, Emma Robertson, Harald Schmidt
Journal: BMJ (2022)

MESSAGES• Outcomes-based pharmaceutical contracts (OBPCs) seek to align payments for drugs with their real-world outcomes and are gaining traction worldwide, including in the UK• OBPCs raise novel issues for patients as medication adherence may affect the revenues of manufacturers and costs to the health system• Adherence however is a highly complex issue, and OBPCs can create tensions between patients and financial outcomes which may be exacerbated further by adherence monitoring technologies• Patient-centredness and transparency must be prioritised in the development of OBPCs and adherence monitoring technologies, and in their potential combination Contributors and sources TB is an NHS GP Specialty Registrar.
Association of COVID-19 Vaccination in Pregnancy With Adverse Peripartum Outcomes
Authors: Deshayne B. Fell, Tavleen Dhinsa, Gillian D. Alton, Eszter Török, Sheryll Dimanlig-Cruz, Annette K. Regan, Ann E. Sprague, Sarah A. Buchan, Jeffrey C. Kwong, Sarah E. Wilson, Siri E. Håberg, Christopher A. Gravel, Kumanan Wilson, Darine El-Chaâr, Mark C. Walker, Jon Barrett, Shannon E. MacDonald, Nannette Okun, Prakesh S. Shah, Shelley D. Dougan, Sandra Dunn, Lise Bisnaire
Journal: JAMA (2022)

There is limited comparative epidemiological evidence on outcomes associated with COVID-19 vaccination during pregnancy; monitoring pregnancy outcomes in large populations is required.To evaluate peripartum outcomes following COVID-19 vaccination during pregnancy.Population-based retrospective cohort study in Ontario, Canada, using a birth registry linked with the provincial COVID-19 immunization database. All births between December 14, 2020, and September 30, 2021, were included.COVID-19 vaccination during pregnancy, COVID-19 vaccination after pregnancy, and no vaccination.Postpartum hemorrhage, chorioamnionitis, cesarean delivery (overall and emergency cesarean delivery), admission to neonatal intensive care unit (NICU), and low newborn 5-minute Apgar score (<7). Linear and robust Poisson regression was used to generate adjusted risk differences (aRDs) and risk ratios (aRRs), respectively, comparing cumulative incidence of outcomes in those who received COVID-19 vaccination during pregnancy with those vaccinated after pregnancy and those with no record of COVID-19 vaccination at any point. Inverse probability of treatment weights were used to adjust for confounding.Among 97 590 individuals (mean [SD] age, 31.9 [4.9] years), 22 660 (23%) received at least 1 dose of COVID-19 vaccine during pregnancy (63.6% received dose 1 in the third trimester; 99.8% received an mRNA vaccine). Comparing those vaccinated during vs after pregnancy (n = 44 815), there were no significantly increased risks of postpartum hemorrhage (incidence: 3.0% vs 3.0%; aRD, -0.28 per 100 individuals [95% CI, -0.59 to 0.03]; aRR, 0.91 [95% CI, 0.82-1.02]), chorioamnionitis (0.5% vs 0.5%; aRD, -0.04 per 100 individuals [95% CI, -0.17 to 0.09]; aRR, 0.92 [95% CI, 0.70-1.21]), cesarean delivery (30.8% vs 32.2%; aRD, -2.73 per 100 individuals [95% CI, -3.59 to -1.88]; aRR, 0.92 [95% CI, 0.89-0.95]), NICU admission (11.0% vs 13.3%; aRD, -1.89 per 100 newborns [95% CI, -2.49 to -1.30]; aRR, 0.85 [95% CI, 0.80-0.90]), or low Apgar score (1.8% vs 2.0%; aRD, -0.31 per 100 newborns [95% CI, -0.56 to -0.06]; aRR, 0.84 [95% CI, 0.73-0.97]). Findings were qualitatively similar when compared with individuals who did not receive COVID-19 vaccination at any point (n = 30 115).In this population-based cohort study in Ontario, Canada, COVID-19 vaccination during pregnancy, compared with vaccination after pregnancy and with no vaccination, was not significantly associated with increased risk of adverse peripartum outcomes. Study interpretation should consider that the vaccinations received during pregnancy were primarily mRNA vaccines administered in the second and third trimester.
EFFECT OF PROPHYLACTIC NITROGLYCERIN ON RADIAL ARTERY SPASM DURING TRANSRADIAL CATHETERIZATION: AN ANALYSIS BASED ON OPERATOR EXPERIENCE
Authors: Roberto Leo da Silva, Pedro B. de Andrade, Alexandre Abizaid, Rodrigo De Moura Joaquim, Thais RW da Silva, Tammuz Fattah, Ramiro Grazziotin Vieira, Vanderlei C. Pereira, Amanda G.M.R. Sousa, Fausto Feres, Jose de Ribamar Costa
Journal: Journal of the American College of Cardiology (2022)
ELEVATED HIGH SENSITIVITY TROPONIN DUE TO NON-CARDIAC CAUSE AND THEIR OUTCOMES IN HOSPITALIZED PATIENTS
Authors: Miguel Antonio Rodriguez Guerra, Alaa Omar, Nisha Ali, Muhammad Saad, Jeirym Miranda, Alvaro Garcia, Pooja Balar, Syed Arsalan Zaidi, Preeti Jadhav, Eduard Sklyar, Jonathan N Bella, Timothy J. Vittorio
Journal: Journal of the American College of Cardiology (2022)
EXPLAINABLE MACHINE LEARNING MODEL FOR RISK STRATIFICATION OF VENTRICULAR ARRHYTHMIA: A CARDIAC MRI STUDY
Authors: Ahmed Fahmy, Julia Cirillo, Jennifer Rodriguez, Amanda Paskavitz, Trishna Sadhwani, Jonathan W. Waks, Warren J. Manning, Daniel Bruce Kramer, Reza Nezafat
Journal: Journal of the American College of Cardiology (2022)
Caspase-8 has dual roles in regulatory T cell homeostasis balancing immunity to infection and collateral inflammatory damage
Authors: Charis E. Teh, Simon P. Preston, Alissa K. Robbins, Michael D. Stutz, James Cooney, Michelle P. Clark, Antonia N. Policheni, Cody C. Allison, Liana Mackiewicz, Philip Arandjelovic, Gregor Ebert, Marcel Doerflinger, Tania Tan, Lucille C. Rankin, Peggy P. Teh, Gabrielle T. Belz, Axel Kallies, Andreas Strasser, Marc Pellegrini, Daniel H. D. Gray
Journal: Science Immunology (2022)

Targeting the potent immunosuppressive properties of FOXP3 + regulatory T cells (T regs ) has substantial therapeutic potential for treating autoimmune and inflammatory diseases. Yet, the molecular mechanisms controlling T reg homeostasis, particularly during inflammation, remain unclear. We report that caspase-8 is a central regulator of T reg homeostasis in a context-specific manner that is decisive during immune responses. In mouse genetic models, targeting caspase-8 in T regs led to accumulation of effector T regs resistant to apoptotic cell death. Conversely, inflammation induced the MLKL-dependent necroptosis of caspase-8–deficient lymphoid and tissue T regs , which enhanced immunity to a variety of chronic infections to promote clearance of viral or parasitic pathogens. However, improved immunity came at the risk of lethal inflammation in overwhelming infections. Caspase-8 inhibition using a clinical-stage compound revealed that human T regs have heightened sensitivity to necroptosis compared with conventional T cells. These findings reveal a fundamental mechanism in T regs that could be targeted to manipulate the balance between immune tolerance versus response for therapeutic benefit.
CLINICAL OUTCOMES OF THE BALLOON-EXPANDABLE VS SELF-EXPANDABLE VALVES IN PATIENTS UNDERGOING TRANSCATHETER AORTIC VALVE REPLACEMENT - A META-ANALYSIS
Authors: Eugene Gan, Yann Shan Keh, Gao Fei, See Hooi Ewe, Mohammed Rizwan Amanullah, Victor Chao, Soo Teik Lim, Kay Woon Ho, Jonathan Yap
Journal: Journal of the American College of Cardiology (2022)
VENTRICULAR RECRUITMENT AND BIVENTRICULAR CONVERSION AFTER SINGLE VENTRICLE PALLIATION IN HYPOPLASTIC LEFT HEART SYNDROME
Authors: Nicholas Oh, Ilias Doulamis, Mossab Saeed, Alvise Guariento, Breanna Piekarski, Pedro J. del Nido, Sitaram M. Emani
Journal: Journal of the American College of Cardiology (2022)
FDA Approval Summary: Nivolumab in Combination with Ipilimumab for the Treatment of Unresectable Malignant Pleural Mesothelioma
Authors: Erica C. Nakajima, Paz J. Vellanki, Erin Larkins, Somak Chatterjee, Pallavi S. Mishra-Kalyani, Youwei Bi, Hisham Qosa, Jiang Liu, Hong Zhao, Missiratch Biable, Lauren Tesh Hotaki, Yuan-Li Shen, Richard Pazdur, Julia A. Beaver, Harpreet Singh, Martha Donoghue
Journal: Clinical Cancer Research (2021)

On October 2, 2020, FDA approved nivolumab with ipilimumab as first-line treatment for adult patients with unresectable malignant pleural mesothelioma (MPM). The approval was based on results from Study CA209743 (CHECKMATE-743), an open-label trial of patients with MPM randomized to receive nivolumab and ipilimumab for up to 2 years (
METABOLIC DETERIORATION IN DIABETIC PATIENTS ASSOCIATES WITH RIGHT VENTRICULAR FREE WALL LONGITUDINAL STRAIN
Authors: Nilda Espinola-Zavaleta, Enrique C. Guerra, Neftali E. Antonio-Villa, Joaquin Berarducci, Javier I. Armenta-Moreno, Nadia Canseco-Leon, Erick Alexanderson-Rosas, Paloma Almeda-Valdes, Alejandro J. Martagon, Alejandro Campos-Muñoz, Carlos A. Aguilar-Salinas
Journal: Journal of the American College of Cardiology (2022)
CLO22-062: The Impact of COVID-19 Infection Among Genitourinary Cancer Patients in Los Angeles County: A Retrospective Analysis
Authors: Catherine Ly, Shiliang Zhang, Lauren Antrim, Nikhita Kathuria-Prakhash, Matthew Ebia, Varsha Tulpule, Anishka D'souza, Gino Kim In
Journal: Journal of the National Comprehensive Cancer Network (2022)
STRESS MYOCARDIAL BLOOD FLOW IS ABNORMAL DURING ACUTE TAKOTSUBO SYNDROME
Authors: Retu Saxena, Joao L. Cavalcante, Dawn R. Witt, Stephanie Zinken Ebnet, Gretchen Benson, Ross Garberich, Opema Lohese, Derek Vang, Peter Kellman, Scott W. Sharkey, Hue Xui
Journal: Journal of the American College of Cardiology (2022)
Defining a Global Map of Functional Group-Based 3D Ligand-Binding Motifs
Authors: Liu Yang, Wei He, Yuehui Yun, Yongxiang Gao, Zhongliang Zhu, Maikun Teng, Zhi Liang, Liwen Niu
Journal: Genomics Proteomics & Bioinformatics (2022)

Uncovering conserved 3D protein-ligand binding patterns on the basis of functional groups (FGs) shared by a variety of small molecules can greatly expand our knowledge of protein-ligand interactions. Despite that conserved binding patterns for a few commonly used FGs have been reported in the literature, large-scale identification and evaluation of FG-based 3D binding motifs are still lacking. Here, we propose a computational method, Automatic FG-based Three-dimensional Motif Extractor (AFTME), for automatic mapping of 3D motifs to different FGs of a specific ligand. Applying our method to 233 naturally-occurring ligands, we define 481 FG-binding motifs that are highly conserved across different ligand-binding pockets. Systematic analysis further reveals four main classes of binding motifs corresponding to distinct sets of FGs. Combinations of FG-binding motifs facilitate the binding of proteins to a wide spectrum of ligands with various binding affinities. Finally, we show that our FG-motif map can be used to nominate FGs that potentially bind to specific drug targets, thus providing useful insights and guidance for rational design of small-molecule drugs.
LEFT ATRIAL LONG AXIS SHORTENING ALLOWS EFFECTIVE QUANTIFICATION OF ATRIAL FUNCTION AND OPTIMIZED RISK PREDICTION FOLLOWING ACUTE MYOCARDIAL INFARCTION
Authors: Sören Jan Backhaus, Simon Rösel, Thomas Stiermaier, Jonas Schmidt-Rimpler, Ruben Evertz, Alexander Schulz, Torben Lange, Johannes Kowallick, Shelby Kutty, Boris Bigalke, Matthias Gutberlet, Gerd Hasenfuss, Holger Thiele, Ingo Eitel, Andreas Schuster
Journal: Journal of the American College of Cardiology (2022)
Covid-19: Coalition pledges $42m to develop broad protection vaccine against betacoronaviruses
Authors: Elisabeth Mahase
Journal: BMJ (2022)

The Coalition for Epidemic Preparedness Innovations (CEPI) has pledged up to $42m to support the development of a vaccine that could provide broad protection against SARS-CoV-2 as well as other betacoronaviruses including severe acute respiratory syndrome and Middle East respiratory syndrome.The vaccine development is being led by biotech company DIOSynVax-which came out of the University of Cambridge.Unlike most other covid-19 vaccines, DIOSynVax is not focusing on the SARS-CoV-2 spike protein as this is vulnerable to mutation.Instead, it is looking at the whole family of coronaviruses to target areas that cannot mutate without the viruses dying or impairing their own ability to replicate. 1 If successful, the team will produce an antigen structure made from multiple synthetic antigens-known as a vaccine antigen payload-that can then be delivered using different vaccine vectors, such as mRNA, adenovirus, and protein based platforms.The funding was announced at the Global Pandemic Preparedness Summit in London on 8 March, which was co-hosted by CEPI and the UK government.As part of the funding agreement, DIOSynVax has committed to achieving equitable access, in line with CEPI's equitable access policy. 2 Commenting on the announcement, research lead Jonathan Heeney, professor of comparative pathology at Cambridge University, said, "Our approach is to be ahead of the next pandemic-to deliver custom designed, immune selected vaccine antigens, which is ideal to prevent diseases caused by complex viruses such as the large and diverse family of coronaviruses.If successful, it will result in a safe, affordable vaccine for widespread use."CEPI chief executive officer Richard Hatchett said, "I am excited to further strengthen CEPI's strong ties to British science through this partnership with DIOSynVax to develop a vaccine with the potential to protect against variants of SARS-CoV-2 and other betacoronaviruses in the future."Coronaviruses have now proven their pandemic potential, so it's imperative for global health security that we invest in research and development now to futureproof the world against the threat of coronaviruses."
IMPACT OF THROMBOCYTOPENIA ON HOSPITAL OUTCOMES OF PATIENTS WITH ACUTE CORONARY SYNDROME AND HOSPITAL COMPLICATIONS: 2016-2019 NATIONAL INPATIENT SAMPLE (NIS) STUDY
Authors: Yaser Khalid, Neethi Dasu, Samir B. Pancholy, Fizan Khalid, Trinava Roy
Journal: Journal of the American College of Cardiology (2022)
ADMISSION HYPERGLYCEMIA IN ACUTE MYOCARDIAL INFARCTION IS ASSOCIATED WITH AN INCREASED RISK OF ARRHYTHMIAS: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Angkawipa Trongtorsak, Jakrin Kewcharoen, Sittinun Thangjui, Maria Yanez-Bello, Mina Sous, Paritosh Prasai, Leenhapong Navaravong
Journal: Journal of the American College of Cardiology (2022)
EFFECTIVE CARDIOVASCULAR SCREENING OF MILITARY RECRUITS REQUIRES AN ELECTROCARDIOGRAM
Authors: Caroline Murphy, Adam Saperstein, Seth Klusewitz, Kyle Bartol, Jonathan A. Aun, Dylan Wessman, Thomas Arnold, John Gideon Symons, Robert E. Goldstein, Matthew Needleman, Marc Alaric Franzos, Mark C. Haigney
Journal: Journal of the American College of Cardiology (2022)
Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes
Authors: Barthelemy Caron, Etienne Patin, Maxime Rotival, Bruno Charbit, Matthew L. Albert, Lluis Quintana-Murci, Darragh Duffy, Antonio Rausell, Laurent Abel, Andres Alcover, Hugues Aschard, Philippe Bousso, Nollaig Bourke, Petter Brodin, Pierre Bruhns, Nadine Cerf-Bensussan, Ana Cumano, Caroline Demangel, Christophe d’Enfert, Ludovic Deriano, Marie-Agnès Dillies, James Di Santo, Françoise Dromer, Gérard Eberl, Jost Enninga, Jacques Fellay, Ivo Gomperts-Boneca, Milena Hasan, Magnus Fontes, Gunilla Karlsson Hedestam, Serge Hercberg, Molly A. Ingersoll, Rose Anne Kenny, Olivier Lantz, Frédérique Michel, Hugo Mouquet, Cliona O’Farrelly, Etienne Patin, Sandra Pellegrini, Stanislas Pol, Antonio Rausell, Frédéric Rieux-Laucat, Lars Rogge, Anavaj Sakuntabhai, Olivier Schwartz, Benno Schwikowski, Spencer Shorte, Frédéric Tangy, Antoine Toubert, Mathilde Touvier, Marie-Noëlle Ungeheuer, Christophe Zimmer, Matthew L. Albert, Darragh Duffy, Lluis Quintana-Murci
Journal: Genome Medicine (2022)

Blood plasma proteins play an important role in immune defense against pathogens, including cytokine signaling, the complement system, and the acute-phase response. Recent large-scale studies have reported genetic (i.e., protein quantitative trait loci, pQTLs) and non-genetic factors, such as age and sex, as major determinants to inter-individual variability in immune response variation. However, the contribution of blood-cell composition to plasma protein heterogeneity has not been fully characterized and may act as a mediating factor in association studies.
CONTEMPORARY TRENDS IN UTILIZATION AND OUTCOMES OF CATHETER-DIRECTED THROMBOLYTIC THERAPY VERSUS SYSTEMIC THROMBOLYTIC THERAPY IN PATIENTS WITH ACUTE PULMONARY EMBOLISM
Authors: Muddasir Ashraf, Saba Irfan, Viviana Zlochiver, Suhail Q. Allaqaband, Tanvir K. Bajwa, M. Fuad Jan
Journal: Journal of the American College of Cardiology (2022)
Serum neutralization of SARS-CoV-2 Omicron sublineages BA.1 and BA.2 in patients receiving monoclonal antibodies
Authors: Timothée Bruel, Jérôme Hadjadj, Piet Maes, Delphine Planas, Aymeric Seve, Isabelle Staropoli, Florence Guivel-Benhassine, Françoise Porrot, William-Henry Bolland, Yann Nguyen, Marion Casadevall, Caroline Charre, Hélène Péré, David Veyer, Matthieu Prot, Artem Baidaliuk, Lize Cuypers, Cyril Planchais, Hugo Mouquet, Guy Baele, Luc Mouthon, Laurent Hocqueloux, Etienne Simon-Loriere, Emmanuel André, Benjamin Terrier, Thierry Prazuck, Olivier Schwartz
Journal: Nature Medicine (2022)
ULTRASOUND NEUROIMMUNE ACTIVATION TREATMENT FOR HEART FAILURE BY LOW-INTENSITY PULSED ULTRASOUND
Authors: Shenrong Zhong, Longhe Zhong, Qianyun Cai, Fengchu Liang, Zhe Deng, Shasha Li, Juefei Wu, Daogang Zha, Yuegang Wang
Journal: Journal of the American College of Cardiology (2022)
Metal‐Organic Framework‐Based Nanoheater with Photo‐Triggered Cascade Effects for On‐Demand Suppression of Cellular Thermoresistance and Synergistic Cancer Therapy
Authors: Yuanyuan Zhu, Yanyan Huang, Tian‐Hao Yan, Jialuo Li, Yongming Li, Hannah F. Drake, Huifei Zhong, Yulong Jin, Rui Zhao, Hong‐Cai Zhou
Journal: Advanced Healthcare Materials (2022)

Nanomedicine with stable light-heat conversion and spatiotemporally controllable drug activation is crucial for the success of photothermal therapy (PTT). Herein, a metal-organic framework (MOF)-based nanoheater with light-triggered multi-responsiveness is engineered to in-situ and on-demand sensitize cancer cells to local hyperthermia. Well-dispersed platinum nanoparticles synthesized inside nanospaces of the MOF are employed as the near-infrared (NIR)-harvesting unit with stable and high light-heat conversion performance. A conformation switchable polymer shell is constructed as a secondary light-responding unit to gate the targeted activation of a molecular inhibitor against thermoresistance. By cascade transformation of light stimuli to downstream signals, the nanoheater enables inhibitor release to go with local heating at the same time restricted in lesion sites to maximize efficacy and minimize systemic toxicity. The efficient photothermal conversion and the blockage of cellular heat-protective pathways provide a dual-mode of action which selectively sensitizes cancer cells to hyperthermia in a spatiotemporally controlled manner. With NIR as the remote switch, the MOF-based nanosystem demonstrates localized and boosted PTT efficacy against cancer both in vitro and in vivo. These results present nanosized MOFs as tailorable and versatile platforms for synergistic and precise cancer therapy.