tbuckley/cabot-search huggingface dataset:
Balloon dilatation of porcine bioprosthetic valves in the pulmonary position.
Authors: J DWaldman, F JSchoen, S EKirkpatrick, J WMathewson, LGeorge, J JLamberti
Journal: Circulation (1987)

Balloon dilatation (BD) of bioprosthetic valves was investigated in vivo and in vitro. Four children with stenotic bioprosthetic porcine valves in the pulmonary position underwent BD of the valve 10 to 24 months after its insertion. Average valve gradient was reduced from 47.5 to 27 mm Hg. Obstruction at the conduit-branch pulmonary artery connection became apparent after dilatation of the valve. These distal stenoses were also dilated. BD technique was tested in vitro with the use of nonstenotic valves in fresh conduits. No damage to the valve or to the conduit was found when oversized balloons were used in a standard fashion or intentionally inflated until rupture. It is concluded that conduit replacement may be deferred by balloon dilatation of obstructed biological valves and/or a stenotic conduit-pulmonary artery anastomosis.
Prevention of transcoronary macromolecular leakage after ischemia-reperfusion by the calcium entry blocker nisoldipine. Direct observations in isolated rat hearts.
Authors: P FMcDonagh, D JRoberts
Journal: Circulation Research (1986)

Coronary microvascular damage appears to play a role in reperfusion injury after myocardial ischemia. This study was designed to afford direct viewing of the effects of myocardial ischemia-reperfusion on the coronary microcirculation and to determine whether pretreatment with the calcium blocker nisoldipine would attenuate any microvascular damage during reperfusion. Four groups of isolated rat hearts were perfused with a solution that contained red cells and fluorescent albumin, but was essentially free of platelets and leukocytes. Group I served as a nonischemic control. Group II hearts were subjected to 30 minutes of no-flow ischemia followed by reperfusion. Group III hearts were pretreated with nisoldipine (1 microgram/min) for 5 minutes before ischemia, and group IV hearts were treated with nitroglycerin (93 micrograms/min) before and after ischemia to mimic the vasodilation caused by nisoldipine. Perfused coronary capillarity and transcoronary extravasation of plasma albumin were measured by direct ...
Covid-19: One in three has neurological or psychiatric condition diagnosed after covid infection, study finds
Authors: Elisabeth Mahase
Journal: BMJ (2021)

Covid-19: One in three has neurological or psychiatric condition diagnosed after covid infection, study finds Elisabeth MahaseOne in three people who have had covid-19 then have a neurological or psychiatric condition diagnosed within six months of infection-the first such diagnosis in 13% of patients-a study of US patient records has found.
Contrast-Enhanced Endoscopic Ultrasound in the Diagnosis of Pancreatic Metastasis
Authors: C Teodorescu, C Pojoga, I Rusu, SD Bolboacă, A Seicean
Journal: Endoscopy (2021)

Aims Less than 5 % of the pancreatic tumors represent a metastasis. It is still difficult to distinguish pancreatic metastasis from a primary pancreatic tumor only by echoendoscopic (EUS) appearance. The vascularity pattern assessed during the contrast-enhanced endoscopic ultrasound (CEUS) has been rarely described.
Changes in diastolic time with various pharmacologic agents: implication for myocardial perfusion.
Authors: HBoudoulas, S ERittgers, R PLewis, C VLeier, A MWeissler
Journal: Circulation (1979)

Diastolic time (DT) is calculated as the cycle length (RR) minus electromechanical systole (QS2). The ratio of DT (RR-QS2) to RR interval times 100, or the percent diastole (%D), varies nonlinearly with heart rate (HR), increasing rapidly with decreasing HR. The effect of commonly used cardioactive agents on %D was studied in five groups of normal subjects. In group 1 (n = 12), propranolol (160 mg daily) increased %D from 55.9 +/- 1.7 to 64.7 +/- 1.3 (p less than 0.001) by slowing HR. In group 2 (n = 12), dobutamine (2.5 micrograms/kg/min) increased %D from 56.4 +/- 1.4 to 61.8 +/- 1.3 (p less than 0.005) by shortening the QS2. In group 3 (n = 10), Cedilanid-D (1.6 mg i.v.) increased %D from 55.5 +/- 1 to 63.2 +/- 0.7 (p less than 0.001), both by slowing the HR and shortening the QS2. In group 4 (n = 12), isoproterenol (2 micrograms/min) increased HR and shortened the QS2 significantly. The net result was a significant reduction of %D from 56.1 +/- 1.4 to 53.5 +/- 1.1, (p less than 0.05). In group 5 (n = ...
The escalating tuberculosis crisis in central and South American prisons
Authors: Katharine S Walter, Leonardo Martinez, Denise Arakaki-Sanchez, Victor G Sequera, G Estigarribia Sanabria, Ted Cohen, Albert I Ko, Alberto L García-Basteiro, Zulma Vanessa Rueda, Rafael A López-Olarte, Marcos A Espinal, Julio Croda, Jason R Andrews
Journal: The Lancet (2021)
Curative Endoscopic Submucosal Dissection of a (T1A) Gastric Cancer Using Pocket Technique Followed by Suturing Closure of the Mucosal Defect
Authors: M Lajin
Journal: Endoscopy (2021)

A 78-year-old female presented with abdominal pain. An EGD revealed a 1.8 cm depressed lesion in the gastric antrum. Biopsies identified high-grade dysplasia.
Long-Term Cardiovascular Outcomes in Systemic Lupus Erythematosus
Authors: Adelina Yafasova, Emil L. Fosbøl, Morten Schou, Bo Baslund, Mikkel Faurschou, Kieran F. Docherty, Pardeep S. Jhund, John J.V. McMurray, Guoli Sun, Søren L. Kristensen, Christian Torp-Pedersen, Lars Køber, Jawad H. Butt
Journal: Journal of the American College of Cardiology (2021)
Evolution of a hereditary cardiac conduction and muscle disorder: a study involving a family with six generations affected.
Authors: H LGraber, D VUnverferth, P BBaker, J MRyan, NBaba, C FWooley
Journal: Circulation (1986)

This study describes six generations of a family with autosomal dominant cardiac conduction system and myocardial disease with recognizable clinical stages. A 20 year follow-up of nine family members, a medical questionnaire of 196, electrocardiographic screening of 91, noninvasive testing of 20, and catheterization with endomyocardial biopsy of six are the basis of this report. The clinical stages are as follows: Stage I occurs in the second and third decades of life and is characterized by an absence of symptoms, normal heart size, sinus bradycardia, and premature atrial contractions. Stage II is marked by first-degree atrioventricular block in the third and fourth decades. Stage III occurs in the fourth and fifth decades and is accompanied by chest pain, fatigue, lightheadedness, and advanced atrioventricular block followed by the development of atrial fibrillation or flutter. Stage IV, in the fifth and sixth decades of life, is characterized by congestive heart failure and recurrent ventricular arrhyt...
Ischemia of the dog heart induces the appearance of a cardiac mRNA coding for a protein with migration characteristics similar to heat-shock/stress protein 71.
Authors: W HDillmann, H BMehta, ABarrieux, B DGuth, W ENeeley, JRoss
Journal: Circulation Research (1986)

Recent evidence indicates that different forms of stress, including hypoxia, can induce specific proteins called heat-shock or stress proteins in various types of mammalian cells. These studies examined whether myocardial ischemia can result in increased levels of proteins with molecular weight and isoelectric point characteristics similar to those described for heat-shock or stress proteins. The left anterior descending coronary artery of the dog heart was completely occluded; normal and ischemic myocardial samples were obtained 6 hours after occlusion; and total cardiac proteins and RNA were prepared. Ribonucleic acid was translated in vitro in a modified rabbit reticulocyte lysate system, and [35S]-methionine-labelled translational products as well as unlabelled cardiac proteins were separated by two-dimensional gel electrophoresis. Total proteins were visualized by silver staining and in vitro translation products quantified by fluorometry. A translatable mRNA coding for a 71,000 dalton peptide with a...
Relationships between myocardial perfusion, myocardial necrosis, and technetium--99m pyrophosphate uptake in dogs subjected to sudden coronary occlusion.
Authors: M LMarcus, R JTomanek, J CEhrhardt, R EKerber, D DBrown, F MAbboud
Journal: Circulation (1976)

The quantitative relationship between abnormalities seen on technetium-99m pyrophosphate (99mTc-PYP) infarct scintigrams and the size of the myocardial infarction is unclear. We evaluated two possible determinants of 99mTc-PYP accumulation: myocardial perfusion measured with 7-10 mu microspheres and the extent of necrosis determined histologically. Hemodynamics and myocardial perfusion to small segments of the left ventricle were measured prior to, 5-10 min, and 44-48 hours following sudden occlusion of the left anterior descending coronary artery in ten awake dogs. 99mTc-PYP was injected i.v. following the third injection of microspheres and the animals were killed 2 hours later. The important findings were as follows: 1) there is a close relationship between the extent of myocardial necrosis observed and the perfusion of segments 5-10 min following coronary occlusion; and 2) that segmental myocardial perfusion is an important determinant of 99mTc-PYP accumulation by myocardial segments which contain are...
Aging of Hematopoietic Stem Cells Is Driven By Regional Specialization of Marrow Macrophages
Authors: Corey M Hoffman, Sarah E Latchney, Mark LaMere, Jason R Myers, John M Ashton, Allison J. Li, Frank Akwaa, Rakhil Rubinova, Amanda McCabe, Julianne N. Smith, Jane L. Liesveld, Benjamin J. Frisch, Michael Rusty Elliott, Katherine C MacNamara, Michael W. Becker, James Palis, Archibald S. Perkins, Laura M. Calvi
Journal: Blood (2017)
Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy.
Authors: GOlivetti, MMelissari, J MCapasso, PAnversa
Journal: Circulation Research (1991)

To determine the effects of aging on the human myocardium, 67 hearts were obtained from individuals who died from causes other than cardiovascular disease. The age interval examined was 17-90 years. Regression analysis demonstrated that the aging process was characterized by a loss of 38 million and 14 million myocyte nuclei/yr in the left and right ventricular myocardium, respectively. This loss in muscle mass was accompanied by a progressive increase in myocyte cell volume per nucleus in both ventricles. Left ventricular myocytes enlarged by 110 microns3/yr, whereas right ventricular myocytes increased by 118 microns3/yr, resulting in a preservation of ventricular wall thickness. However, the cellular hypertrophic response was unable to maintain normal cardiac mass. Left and right ventricular weights decreased by 0.70 and 0.21 g/yr, respectively. In conclusion, loss of cells and enlargement of the remaining myocytes may represent the structural basis for the reduced compensatory capacity of the aged hea...
Insensitivity of the cold pressor stimulation test for the diagnosis of coronary artery disease.
Authors: A GWasserman, LReiss, R JKatz, RLeiboff, PCleary, V MVarma, R CReba, A MRoss
Journal: Circulation (1983)

Cold pressor stimulation (CPS) was compared with supine bicycle exercise during radionuclide ventriculography as a procedure for diagnosing coronary artery disease (CAD). Thirty patients were studied. In the 18 patients with angiographically proved CAD, left ventricular ejection fraction (LVEF) decreased a mean of 5.0 +/- 1.0 ejection fraction units (+/- SEM) in response to CPS. Only two patients developed a new wall motion abnormality. In response to maximal supine exercise, the CAD group showed a mean decrease in LVEF from rest of 1.9 +/- 1.1%. Nine patients developed an exercise-induced wall motion abnormality. In the 12 patients with angiographically proved normal coronary arteries, LVEF decreased a mean of 5.8 +/- 1.3 units in response to CPS and increased a mean of 9.2 +/- 1.2% in response to exercise. Thus, the LVEF response to CPS was not significantly different in the CAD and normal groups (5.0 +/- 1.0 vs 5.8 +/- 1.3, NS). These same patients demonstrated the expected difference in LVEF response ...
Myocardial lactate and adenosine metabolite production as indicators of exercise-induced myocardial ischemia in the dog.
Authors: T RVrobel, C RJorgensen, R JBache
Journal: Circulation (1982)

To determine the value of lactate and the adenosine metabolites inosine and hypoxanthine as indicators of myocardial ischemia, we measured the levels of these metabolites in arterial and coronary sinus blood of nine chronically instrumented dogs subjected to exercise stress before and during reversible circumflex coronary artery occlusion. The degree of circumflex bed hypoperfusion was measured by 15-mu microspheres and the reduction in circumflex coronary flow was measured with a proximal flow probe. Adenosine metabolites, although below the level of accurate detection in our laboratory in arterial blood (i.e., 0.5 microM/l), were detected in coronary sinus blood (range 2.7--18.7 microM/l) in 26 of 33 studies with partial circumflex occlusion when circumflex flow was reduced to less than 80% of that seen during exercise without occlusion and when only subendocardial perfusion was reduced. Global left ventricular flow and transmural flow in nonischemic beds did not correlate with positive studies. Myocard...
Endoluminal Vacuum Therapy Using a New “Fistula Sponge” In Small Defects of the Upper Gastrointestinal Tract – A Comparative, Single Center Study
Authors: M Ellrichmann, J Hoffmann, V Kataev, F Richter, JH Egberts, S Schreiber, T Becker, W von Schoenfels, B Reichert
Journal: Endoscopy (2021)

Aims Anastomotic insufficiencies(AI) and perforations of the upper gastrointestinal tract(uGIT) result in high morbidity and mortality. Besides surgical revision and endoscopic stent placement the endoluminal vacuum therapy(EVT) has been established as an additional strategy. So far, the Eso-Sponge is the only licensed EVT system with limitations in very small defects. Therefore, a fistula sponge(FS) was established in our center for the treatment of small defects of the uGIT as a new therapeutic approach. To evaluate success rates, indications and complications of both EVT options in a retrospective, single-center trial.
Assessment of anatomic and physiological severity of single-vessel coronary artery lesions by dipyridamole echocardiography. Comparison with positron emission tomography and quantitative arteriography.
Authors: EPicano, OParodi, FLattanzi, GSambuceti, M JAndrade, PMarzullo, AGiorgetti, PSalvadori, MMarzilli, ADistante
Journal: Circulation (1994)

BACKGROUNDThe aim of this study was to compare the results of dipyridamole-echocardiography test (DET: two-dimensional echo monitoring during dipyridamole infusion up to 0.84 mg/kg over a period of 10 minutes) with both anatomic and physiological parameters of coronary artery disease severity, assessed by computer-assisted quantitative coronary arteriography, and regional coronary flow reserve, measured by [13N]ammonia (13NH3) and dynamic positron emission tomography (PET), respectively.METHODS AND RESULTSWe studied 31 patients with a history of chest pain and neither previous myocardial infarction nor resting wall motion abnormalities. Eighteen patients had single-vessel disease (> 50% stenosis of one major coronary vessel), and 13 had normal coronary arteries. The criterion for DET positivity was the appearance of a new transient regional wall motion abnormality. In patients with a positive DET, two parameters were evaluated: the dipyridamole time (ie, the time from the beginning of drug infusion to the...
Blood flow pattern of the interatrial communication in patients with complete transposition of the great arteries: a pulsed Doppler echocardiographic study.
Authors: GSatomi, MNakazawa, ATakao, KMori, KTouyama, TKonishi, HTomimatsu, KNakamura
Journal: Circulation (1986)

We analyzed blood flow pattern in the interatrial communication in 24 patients with complete transposition of the great arteries (TGA). Eight had TGA with atrial shunt (group 1), nine had TGA with patent ductus arteriosus or ventricular septal defect (group 2), and seven had pulmonary arterial banding and Blalock-Taussig shunt (group 3). The flow pattern was determined at the site of atrial septal defect by Doppler echo beam directed as perpendicular to the septum as possible. The flow pattern was composed of a left-to-right (L-R) flow and right-to-left (R-L) flow. The turning point (T1) from the R-L to L-R flow occurred immediately after the initiation of the QRS on the electrocardiogram and was common in all groups. The other turning point (T2) from L-R to R-L occurred after the second heart sound (S2). The S2-T2 interval decreased on inspiration, indicating prolongation of the period of R-L flow. The minimum S2-T2 interval ranged from 20 to 70 (mean +/- SD 50 +/- 18) msec in group 1, from 70 to 130 (11...
Glucocorticoid induction of Kv1.5 K+ channel gene expression in ventricle of rat heart.
Authors: KTakimoto, E SLevitan
Journal: Circulation Research (1994)

Multiple voltage-gated K+ channels contribute to the repolarization phases of the cardiac action potential and are targets of several antiarrhythmic drugs. The Kv1.5 K+ channel gene is expressed in the heart, and heterologous expression of this gene generates a slowly inactivating K+ current. Previously, we found that glucocorticoids specifically upregulate pituitary Kv1.5 gene expression. To test whether these steroids might also induce Kv1.5 gene expression in the heart, cardiac channel mRNA and protein were measured by RNase protection assay and by immunoblotting with antibody specific for the extracellular domain of Kv1.5 polypeptide. Kv1.5 mRNA and immunoreactive protein appeared to be more abundant in rat ventricle than atrium. Reduction of endogenous glucocorticoids by adrenalectomy decreased ventricular Kv1.5 mRNA approximately 8-fold, which was estimated by using cyclophilin mRNA as an internal control. Kv1.5 immunoreactive protein also decreased approximately 6-fold. Injection of dexamethasone i...
Arrested rotation of the outflow tract may explain double-outlet right ventricle.
Authors: M PBostrom, G MHutchins
Journal: Circulation (1988)

In a previous study the possibility that tetralogy of Fallot and transposition of the great arteries may result of embryonic arrests in the normal rotation of the junction of the outflow tract and the great arteries was investigated. The results suggested that the development of other transposition complexes such as double-outlet right ventricle might also be related to arrests in this process of rotation. To further study this question 20 normal hearts and 15 hearts with double-outlet right ventricle obtained at autopsy were studied. The angle of the aortic-to-pulmonary valve axis relative to the inferior surface of the heart, as viewed from apex to base, was measured from postmortem radiographs. For normal hearts the mean angle was 81 +/- 7(SE) degrees. For 13 of the 15 hearts with double-outlet right ventricle the mean angle was 4 +/- 7(SE) degrees. Two hearts with double-outlet right ventricle showed markedly divergent aortic-to-pulmonary valve angles, with a mean of 228 +/- 11(SE) degrees, and were t...
Detection, localization, and quantitation of bioprosthetic mitral valve regurgitation. An in vitro two-dimensional color-Doppler flow-mapping study.
Authors: B FVandenberg, K CDellsperger, K BChandran, R EKerber
Journal: Circulation (1988)

The usefulness of two-dimensional color-Doppler flow-imaging (2D Doppler) in the detection, localization, and quantitation of bioprosthetic mitral valve regurgitation is uncertain. Mitral bioprostheses, before and after the creation of transvalvular (n = 33), paravalvular (n = 17), or combined (n = 23) defects, were mounted in a pulsed duplication system (flow rates, 2.5-6.5 l/min; pulse rate, 70 beats/min). An Aloka 880 2D Doppler system (Japan) was used to image the regurgitant jets in the simulated left atrial chamber, analogous to images obtained with transesophageal echocardiography. Jet area was corrected to an estimate of stroke volume: 2D Doppler measurements were divided by [(valve effective orifice area) X (continuous-wave Doppler-determined mean diastolic filling velocity)]/pulse rate. Regurgitant fraction and regurgitant volume were measured by an electromagnetic flow probe. 2D Doppler correctly identified the presence and location of paravalvular regurgitation. In transvalvular and combined t...
Questions About Genetic Variation in 9p21 as a Predictor of Cardiovascular Risk
Authors: John R. Schwarzenbach
Journal: Annals of Internal Medicine (2009)

Letters19 May 2009Questions About Genetic Variation in 9p21 as a Predictor of Cardiovascular RiskJohn R. Schwarzenbach, MDJohn R. Schwarzenbach, MDFrom Veterans Affairs Black Hills Health Care System, Hot Springs, SD 57747.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-10-200905190-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I have a question about the article by Paynter and colleagues (1). Can the 9p21 gene, or even KIF6, be useful in determining who is more likely to respond to statin therapy? There are probably a lot of people who receive statins who don't need them, judging by number-needed-to-treat statistics from several previous trials. Can we, by using these genetic tests, be more specific about whom we do and do not treat?John R. Schwarzenbach, MDVeterans Affairs Black Hills Health Care SystemHot Springs, SD 57747Reference1. Paynter NP, Chasman DI, Buring JE, Shiffman D, Cook NR, Ridker PM. Cardiovascular disease risk prediction with and without knowledge of genetic variation at chromosome 9p21.3. Ann Intern Med. 2009;150:65-72. [PMID: 19153409] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Veterans Affairs Black Hills Health Care System, Hot Springs, SD 57747.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCardiovascular Disease Risk Prediction With and Without Knowledge of Genetic Variation at Chromosome 9p21.3 Nina P. Paynter , Daniel I. Chasman , Julie E. Buring , Dov Shiffman , Nancy R. Cook , and Paul M. Ridker Questions About Genetic Variation in 9p21 as a Predictor of Cardiovascular Risk Nina P. Paynter , Nancy R. Cook , and Paul M Ridker Questions About Genetic Variation in 9p21 as a Predictor of Cardiovascular Risk Jeff Gulcher and Kari Stefansson Questions About Genetic Variation in 9p21 as a Predictor of Cardiovascular Risk Lukasz Kiljanek Metrics 19 May 2009Volume 150, Issue 10Page: 736KeywordsConflicts of interestGeneticsStatins ePublished: 19 May 2009 Issue Published: 19 May 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Analysis of the properties of binding of calcium-channel activators and inhibitors to dihydropyridine receptors in chick heart membranes.
Authors: A CMaan, M MHosey
Journal: Circulation Research (1987)

The interaction of 1,4-dihydropyridine derivatives with their receptors on voltage-dependent calcium channels in cardiac membranes was studied to determine if there are basic differences in the binding properties of ligands that cause inhibition or activation of calcium channels. The binding characteristics of 6 pure stereoisomers, (-) and (+)202-791, (-) and (+)Bay k 8644, (-) and (+)PN 200-110, as well as racemic Bay k 8644 and nitrendipine, were compared. Competition studies using the cold ligands and 3 different radiolabelled dihydropyridines, (+)[3H]PN 200-110, (+/-)[3H]nitrendipine, and (+/-)[3H]Bay k 8644, showed that, for each combination tested, the labelled dihydropyridine could be displaced by the cold dihydropyridine. The binding reactions were markedly affected by temperature. The Kd values for most compounds were significantly higher (5-19 times) at 0 degrees than at 37 degrees C. In contrast, the affinity of (+)PN 200-110 was similar at 0 degrees and 37 degrees C, but slightly higher at 25 ...