tbuckley/cabot-search huggingface dataset:
Gas-Alternating-Water Infusion Method: A Novel Technique Of Endoscopic Submucosal Dissection For Colorectal Tumors Regardless Of Gravity
Authors: S Chen, H Shi, H He, F Dong, Y Jiang, J Huang, J Lin
Journal: Endoscopy (2021)

Aim To evaluate the feasibility and safety of ESD using gas-alternating-water infusion method (GAW-ESD) for colorectal laterally spreading tumors.
De subitaneis mortibus. XXVIII. Apoplexy of the heart.
Authors: T NJames
Journal: Circulation (1978)

Apoplexy of the heart can be responsible for sudden and for recurring instability of cardiac rhythm and conduction, and for the clinical counterparts of syncope and sudden death. Every pathophysiological mechanism which produces cerebral apoplexy has its counterpart in apoplexy of the heart. Among the mechanisms documented are thrombosis, embolism and rupture of those special vessels supplying the sinus node, atrioventicular (A-V) node and His bundle. Apoplexy of the heart can occur either with or without significant or recognizable ventricular myocardial infarction. Acute vascular accidents within the critical centers of cardiac impulse formation and conduction deserve more frequent consideration in the explanation of unusual cases of epilepsy, of seizure disorders of the elderly, of neurologic manifestations (which may be secondary as well as primary) of systemic diseases such as lupus erythematosus or thrombotic thrombocytopenic purpura, and indeed of every case of otherwise unexplanined syncope or s...
Effects of diastolic transseptal pressure gradient on ventricular septal position and motion.
Authors: IKingma, J VTyberg, E RSmith
Journal: Circulation (1983)

Despite the clinical prevalence of paradoxic interventricular septal (IVS) motion, its pathogenesis remains unclear. To assess the influence of the end-diastolic transseptal pressure gradient, we studied eight open-chest dogs during right ventricular (RV) volume loading (induced by opening a Dacron shunt between the pulmonary artery [PA] and right atrium), RV pressure loading (constriction of PA), and left bundle branch block (RV pacing). Ultrasonic crystals in the IVS and on the RV and left ventricular (LV) free walls (FW) allowed measurement of RV septal-to-free wall (S-FW) and LVS-FW diameters. Another set measured the anteroposterior (AP) diameter of the LV (LVAP). Two-dimensional and M mode echocardiograms confirmed IVS shape and motion pattern, respectively. RV volume load caused a reduction in mean transseptal end-diastolic pressure gradient from 2.1 to -2.6 mm Hg (p less than .001), with a concomitant increase in mean end-diastolic RVS-FW diameter of 2.5 mm (p less than .001) and a decrease in LVS...
Prolonged treatment with oral retinoids in adults: no influence on the frequency and severity of spinal abnormalities
Authors: R. J. DOOREN-GREEBE, J. A. M. LEMMENS, T. BOO, N. M. A. HANGX, A. L. A. KULJPERS, P. C. M. KERKHOF
Journal: British Journal of Dermatology (1996)

It is generally accepted that the spine is the site of predilection for retinoid-induced i abnormalities.However, the reported prevalence of skeletal problems varies widely.To investigate the frequency and severity of retinoid-induced spinal abnormalities, all records of patients who underwent spinal radiographs at the request of the department of dermatology between 198 3 and 199 3 were reviewed.This group of 1 35 patients comprised the total population of retinoid-treated patients and those patients who were investigated for possible future retinoid treatment.The mean treatment period in the total group was 30 months and the mean cumulative dose of retinoid was 31 g.In 50 patients the treatment period was ^ 24 months with 30 patients being treated for more than 48 months.Baseline radiographs were available from 26 patients and these were comp, with the most recent X-rays during treatment.The mean treatment period in this 'prospective group' was 2 5 months and the mean cumulative dose of retinoid was 25 g. The prevalence of diffuse idiopathic skeletal hyperostosis (DISH), degenerative changes and osteoporosis in the total group was respectively 16%, 53% and29%.There was no statistically significant relation between the duration of treatment or the cumulative dose and the prevalence or of DISH, degenerative changes and osteoporosis.Only the age of the t \ 1 1 significantly related to the frequency and severity of skeletal abnormalities.In the 'prospective group', again, no important changes were observed between the radiographs at baseline and during In this study no relation whatsoever between spinal abnormalities and prolonged oral retinoid established.The performance of annual routine spinal radiographs during retinoid treatment is not necessary in our opinion.Additional controlled and prospective studies on spinal and extraspinal skeletal abnormalities are required to develop definitive screening guidelines for patients submitted to long-term retinoid treatment.' C IS .
活性心サルコイドーシス患者の肉芽腫でのマクロファージと多核巨大細胞における骨髄関連蛋白質複合体(MRP8/14)の発現増加
Authors: Terasaki Fumio, Fujita Masatoshi, Shimomura Hiroaki, Tsukada Bin, Otsuka Koji, Otsuka Kaoru, Katashima Takashi, Ikemoto Masaki, Kitaura Yasushi
Journal: Circulation (2007)
Adult Blood Lead Epidemiology and Surveillance—United States, 2003-2004
Journal: JAMA (2006)

Reported by: JW Dilley, San Francisco AIDS Health Project; JD Klausner, MD, W McFarland, PhD, TA Kellogg, MA, R Kohn, MPH, WWong, MD, BT Louie, San Francisco Dept of Public Health; M Taylor, MD, PR Kerndt, MD, J Carlos, MPH, CR Chavers, MSPH, Los Angeles County Dept of Public Health, Los Angeles; GBolan, MD, California Dept of Health Svcs. SD Holmberg, MD, AE Greenberg, MD, RH Byers, PhD, Div of HIV/AIDS Prevention, National Center for HIV, STD, and TB Prevention; KA Buchacz, PhD, P Patel, MD, JB King, MD, EIS officers, CDC.
Uric acid: a risk factor for coronary heart disease?
Authors: V WPersky, A RDyer, EIdris-Soven, JStamler, R BShekelle, J ASchoenberger, D MBerkson, H ALindberg
Journal: Circulation (1979)

The association between serum uric acid and the prevalence of ECG abnormalities was analyzed for 24.997 employed men and women, white and black, age 18--64 years, from the Chicago Heart Association (CHA) Detection Project in Industry. In addition, the relationships between uric acid and 5-year mortality from all causes, from cardiovascular diseases (CVD), and from coronary heart disease (CHD) were analyzed for 7804 white men and women age 45--64 years from this study and 967 white men age 44--63 years from the Chicago People's Gas Company Study. For men, the association between uric acid and the prevalence of ECG abnormalities and with mortality appear to be secondary to associations between uric acid and other risk factors. For women, however, the associations could not be explained by other risk factors.
Protein kinase C isoform expression and regulation in the developing rat heart.
Authors: V ORybin, S FSteinberg
Journal: Circulation Research (1994)

To determine whether age-dependent differences in cardiac responses to autonomic agonists could result from developmental changes in protein kinase C (PKC) isoform expression, we probed extracts from the fetal, neonatal, and adult heart as well as cultured neonatal and isolated adult ventricular myocytes with specific antisera to calcium-dependent (alpha and beta) and calcium-independent (delta, epsilon and zeta) isoforms of the enzyme. Although PKC-beta immunoreactivity could not be detected in cultured neonatal or isolated adult ventricular myocytes, adult and neonatal myocytes expressed multiple other isoforms of PKC. Our studies revealed an age-dependent decline in the immunoreactivity for three PKC isoforms. PKC-alpha was detected in extracts from the fetal and 2-day-old neonatal heart as well as cultured neonatal rat ventricular myocytes. Only faint PKC-alpha immunoreactivity was detected in extracts from the adult heart, and PKC-alpha was not detected in extracts from isolated adult ventricular myo...
Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis
Authors: Francesco Violi, Roberto Cangemi
Journal: New England Journal of Medicine (2010)

ConclusionsVitamin E was superior to placebo for the treatment of nonalcoholic steatohepatitis in adults without diabetes.There was no benefit of pioglitazone over placebo for the primary outcome; however, significant benefits of pioglitazone were observed for some of the secondary outcomes.(ClinicalTrials.govnumber, NCT00063622.)
Developmental changes in guanine nucleotide regulatory proteins in the rat myocardial alpha 1-adrenergic receptor complex.
Authors: H MHan, R BRobinson, J PBilezikian, S FSteinberg
Journal: Circulation Research (1989)

During development, the cardiac alpha 1-adrenergic chronotropic response changes from positive in the neonate to negative in the adult. The negative chronotropic effect of alpha 1-adrenergic stimulation in the adult depends on maturation of sympathetic innervation and the presence of a pertussis toxin (PT)-sensitive guanine nucleotide-binding (G) protein. To examine the possibility of a developmental change in coupling of a PT-sensitive G protein to the alpha 1-adrenergic receptor, radioligand binding experiments with the iodinated alpha 1-selective radioligand [125I]-I-2-[beta-(4-hydroxyphenyl)ethylaminomethyl]tetralone ([ 125I]-IBE 2254) were performed on membranes prepared from control and PT-treated neonatal and adult rat hearts. Scatchard analysis showed fewer alpha 1-adrenergic receptors in the adult than in the neonate (168 +/- 10 fmol/mg protein in the neonate vs. 124 +/- 13 fmol/mg protein in the adult), but similar affinities (equilibrium dissociation constant 124 +/- 29 pM in the neonate vs. 14...
Altered calcium handling in left ventricular pressure-overload hypertrophy as detected with aequorin in the isolated, perfused ferret heart.
Authors: L ABentivegna, L WAblin, YKihara, J PMorgan
Journal: Circulation Research (1991)

The purpose of this study was to test the hypothesis that systolic and diastolic dysfunction in left ventricular pressure-overload hypertrophy is caused by abnormal intracellular calcium handling. Experiments were performed with intact, buffer-perfused, isovolumic ferret hearts (n = 9 hypertrophied, n = 9 control) that were loaded with the bioluminescent indicator aequorin to monitor changes in cytoplasmic calcium. In each experiment, left ventricular pressure and intracellular calcium transients were simultaneously recorded. Compared with their age-matched controls, significant hypertrophy of the left ventricle developed 4 weeks after postvalvular aortic banding; at the time the animals were killed, the left ventricular weight/body weight ratio was increased in the banded animals (5.3 x 10(-3) versus 3.6 x 10(-3), p less than 0.001). As indicated by the diastolic pressure-volume relation, left ventricular distensibility was significantly diminished in the hypertrophied hearts. In comparison to the contro...
Factors contributing to increased vascular fibrinolytic activity in mongrel dogs.
Authors: I MLang, J JMarsh, R GKonopka, M AOlman, B RBinder, K MMoser, R RSchleef
Journal: Circulation (1993)

BACKGROUNDNumerous investigators have observed that pulmonary emboli are rapidly lysed in a canine model system. This study was undertaken to delineate the unique mechanism that accounts for the rapid dissolution of pulmonary emboli in mongrel dogs.METHODS AND RESULTSCanine plasminogen activator (PA) activity (2.6 +/- 1.1 IU/mL acidified platelet-poor plasma [PPP], < 0.3 IU/mL acidified whole blood serum [WBS], mean +/- SD; n = 6) and PA inhibitor activity (6.1 +/- 2.6 U/mL PPP, 35.4 +/- 7.8 U/mL WBS; n = 6) were determined in standard plasminogen-based chromogenic assays. Analysis of canine PPP, WBS, platelet lysates, and primary canine endothelial cell (EC) cultures by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and fibrin autography revealed a plasminogen-dependent lytic zone at 45-kd relative molecular mass that was shown to be related to urokinase-type PA (u-PA) by its selective inhibition through amiloride. Analysis of canine platelets on standard 125I fibrin plate assays revealed a ne...
Differences in transient outward currents of feline endocardial and epicardial myocytes.
Authors: TFurukawa, R JMyerburg, NFurukawa, A LBassett, SKimura
Journal: Circulation Research (1990)

Whole-cell voltage-clamp experiments were performed on enzymatically dissociated single ventricular myocytes harvested from feline endocardial and epicardial surfaces. The studies were designed to test the hypothesis that the differences in the amplitude of transient outward current (Ito) contribute to the difference in action potential configuration between endocardial and epicardial myocytes. In the control state, action potentials recorded from epicardial cells demonstrated a prominent notch between phases 1 and 2, and membrane current recordings displayed a prominent Ito, whereas in endocardial cells the notch in action potentials and Ito were small. External application of 4-aminopyridine (2 mM) reduced the amplitudes of notch and Ito in epicardial cells but not in endocardial cells. After application of 4-aminopyridine (2 mM) and caffeine (5 mM), the notch and Ito were abolished completely in both endocardial and epicardial cells. The first component of Ito (Ito1) was present in all epicardial cells...
Left ventricular adaptation to sustained pressure overload in the conscious dog.
Authors: BCrozatier, DCaillet, OBical
Journal: Circulation Research (1984)

The early adaptation to aortic stenosis was studied in eight conscious dogs previously instrumented with a left ventricular micromanometer and ultrasonic crystals measuring left ventricular minor equator, left ventricular major axis, and ventricular wall thickness. Data were compared during control, acute inflation of a supravalvular aortic cuff occluder and 24 hours after aortic stenosis with and without beta-blockade. Acute aortic stenosis increased peak systolic pressure and end-systolic pressure with a decrease of percent systolic shortening of minor diameter (% delta L). Twenty-four hours after aortic constriction for heart rates, end-diastolic dimensions, and systolic pressures similar to those measured during acute aortic stenosis, % delta L was significantly increased, compared with acute aortic constriction, and was close to control values. End-systolic diameter was not significantly different from control during sustained pressure overload, although end-systolic stress was increased by 26.7 +/- ...
Inadequacy of Ferritin Trends for Predicting Changes in LIC Risk Category in Transfusion Depedent and Well Chelated Patients with Haemoglobinopathies
Authors: Angela Vitrano, Massimiliano Sacco, Rosamaria Rosso, Alessandra Quota, Daniela Fiorino, Esther Natalie Oliva, Calogera Gerardi, Gaetano Roccamo, Vincenzo Spadola, Aldo Filosa, Lorenzo Tesé, Giuseppina Calvaruso, Lorella Pitrolo, Laura Mistretta, Filippo Cassarà, Rosario Di Maggio, Aurelio Maggio
Journal: Blood (2017)
Role of preclinical cardiovascular disease in the evolution from risk factor exposure to development of morbid events.
Authors: R BDevereux, M HAlderman
Journal: Circulation (1993)

Conventional risk factors (especially high arterial pressure, elevated cholesterol and glucose levels, and cigarette smoking) are useful predictors of morbid atherosclerotic and hypertensive events, and their control variably reduces the incidence of events. However, both the ability to predict risk and the ability to reduce it by modification of established risk factors are limited. These limitations occur in part because the progression from risk factor exposure to morbid events depends on the variable likelihood that individuals exposed to the same risk factors will progress through two stages: the development of asymptomatic or  anatomic and functional cardiovascular disease in response to standard risk factors and other variables, and the precipitation of morbid events by progression of preclinical disease or by the action of additional triggering mechanisms in the presence of preclinical disease. Advances in diagnostic methodology now make possible accurate noninvasive detection in ma...
Heterogeneous distribution of a diffusional tracer in the aortic wall of normal and atherosclerotic rabbits.
Authors: HTsutsui, HTomoike, MNakamura
Journal: Circulation Research (1990)

Tracer distribution as an index of nutritional support across the thoracic and abdominal aortas in rabbits in the presence or absence of atherosclerotic lesions was evaluated using [14C]antipyrine, a metabolically inert, diffusible indicator. Intimal plaques were produced by endothelial balloon denudation of the thoracic aorta and a 1% cholesterol diet. After a steady intravenous infusion of 200 microCi of [14C]antipyrine for 60 seconds, thoracic and abdominal aortas and the heart were excised, and autoradiograms of 20-microns-thick sections were quantified, using microcomputer-aided densitometry. Regional radioactivity and regional diffusional support, as an index of nutritional flow estimated from the timed collections of arterial blood, was 367 and 421 nCi.g-1 (82 and 106 ml.min-1.100 g-1) in thoracic aortic media of the normal and atherosclerotic rabbits, respectively. Radioactivity at the thickened intima was 179 nCi.g-1 (p less than 0.01 versus media). The gruel was noted at a deeper site within the...
The metabolism-modulating activity of IL-17 signaling in health and disease
Authors: Rami Bechara, Mandy J. McGeachy, Sarah L. Gaffen
Journal: The Journal of Experimental Medicine (2021)

IL-17 was discovered nearly 30 yr ago, but it has only been recently appreciated that a key function of this cytokine is to orchestrate cellular and organismal metabolism. Indeed, metabolic regulation is integrated into both the physiological and the pathogenic aspects of IL-17 responses. Thus, understanding the interplay between IL-17 and downstream metabolic processes could ultimately inform therapeutic opportunities for diseases involving IL-17, including some not traditionally linked to this cytokine pathway. Here, we discuss the emerging pathophysiological roles of IL-17 related to cellular and organismal metabolism, including metabolic regulation of IL-17 signal transduction.
Augmentation of regional coronary blood flow by intra-aortic balloon counterpulsation in patients with unstable angina.
Authors: R MFuchs, K PBrin, J ABrinker, P AGuzman, R RHeuser, F CYin
Journal: Circulation (1983)

Intra-aortic balloon counterpulsation is capable of reducing afterload in patients with unstable angina. Whether it is also capable of augmenting coronary blood flow to poststenotic myocardium is controversial. We studied seven patients receiving maximal drug therapy and requiring balloon pumping for unstable angina as balloon volume and assist ratio were altered. All patients had greater than 90% stenosis of the proximal left anterior descending coronary artery. With maximal augmentation (40 cc balloon volume, 1:1 assist ratio) great cardiac vein flow, representing the efflux from the left anterior descending coronary artery bed, rose from a baseline of 52 +/- 20 to 67 +/- 25 ml/min (mean +/- SD, p = .004) and mean aortic diastolic pressure increased from 77 +/- 13 to 99 +/- 33 mm Hg (p = .004). Increased great cardiac vein flow correlated with increased mean aortic diastolic pressure across changes in balloon volumes (off, 20 cc, 30 cc, and 40 cc) and changes in assist ratio (off, 1:4, 1:2, and 1:1) (p ...
Pulmonic regurgitation due to valvular tophi.
Authors: E ICurtiss, T RMiller, L SShapiro
Journal: Circulation (1983)

Documented cardiac tophi are rare and have not previously been reported to cause clinically manifest valvular disease. A 31-year-old male with complex cyanotic congenital heart disease (Taussig-Bing anomaly) and secondary tophaceous gouty arthritis is described. Terminally, he presented with clinical evidence of a brain abscess and a new semilunar regurgitant murmur. Two-dimensional echocardiography suggested vegetative lesions as the cause of the murmur. The patient was treated for infective endocarditis. At autopsy, the cause of the semilunar regurgitant murmur was shown to be sterile tophi located along the line of pulmonary valvular coaptation. Tophaceous deposits were also present in the mitral valve.
Reply to K. Ando et al
Authors: Joseph A. Sparano, Michael R. Crager, Gong Tang, Robert J. Gray, Salomon M. Stemmer, Steven Shak
Journal: Journal of Clinical Oncology (2021)

We appreciate the interest expressed by Ando et al 1 in our publication describing the development and validation of the RSClin educational tool 2 and the opportunity to address their comments.The first concern is related to the estimation of absolute chemotherapy benefit provided by RSClin, a new feature not included in the RSPC model using older trial data. 3Ando et al 1 stated, "The majority of patients enrolled in the two studies [B-20 and TAILORx] received cyclophosphamide, methotrexate, and fluorouracil [CMF], or methotrexate and fluorouracil [MF].," which could result in underestimation of chemotherapy benefit.Of the 4,921 patients randomly assigned to chemotherapy in TAILORx or B-20 and included in the meta-analysis, only 565 (11%) received CMF/MF.The remaining patients who received chemotherapy had regimens that included anthracyclines, taxanes, or both.In the TAILORx arm including those with a recurrence score (RS) of 26 or higher treated with adjuvant chemotherapy, distant recurrence rates were similar irrespective of whether the patients received regimens including anthracyclines, taxanes, or both. 4Although CMF may be less effective in preventing distant recurrence than such regimens, 5 it may be perfectly appropriate choice for older women or those with comorbidities.
Improving selection of patients with metastatic colorectal cancer to benefit from cetuximab based on KIR genotypes
Authors: Barbara Manzanares-Martin, Arancha Cebrián Aranda, Laura del Puerto-Nevado, Rafael González, Sonia Solanes, Maria Auxiliadora Gómez-España, Jesús García-Foncillas, Enrique Aranda
Journal: Journal for ImmunoTherapy of Cancer (2021)

Aim Cetuximab is a standard-of-care treatment for KRAS wild-type metastatic colorectal cancer (mCRC), but it may also be effective in a subgroup of KRAS mutant patients by its immunomodulatory activity. Here, we explore if KIR (killer cell immunoglobulin-like receptor) genotyping can provide a significant added value in the clinical outcome of patients with KRAS mutant mCRC based on cetuximab treatment. Methods We included 69 patients with histologically confirmed mCRC and KRAS mutation, positive EGFR expression, and Eastern Cooperative Oncology Group performance status ≤2. Based on KIR gene content, haplotype (A or B) was defined and genotypes (AA or Bx) were grouped for each patient. Results We demonstrated with new evidence the immunomodulatory activity of cetuximab in patients with KRAS mutant mCRC. Patients with homozygous genotypes (AA or BB) showed shorter 12-month progression-free survival (PFS12) and poorer overall survival (OS) than those with heterozygotes (AB). Moreover, multivariate analysis confirmed stratification of patients based on genotype was an independent marker of PFS12 (HR 2.16) and the centromeric and telomeric distribution of KIRs was an independent predictor of both PFS12 (HR 2.26) and OS (HR 1.93) in patients with mCRC with KRAS mutation treated with cetuximab. Conclusions Selection of patients with mCRC based on their KIR genotypes opens a therapeutic opportunity for patients with KRAS mutation, and it should be tested in clinical trials in comparison with other alternatives with scarce benefit. Trial registration number NCT01450319 , EudraCT 2010-023580-18.