Increased Serum Lipoprotein(a) Levels in Patients with Early Renal Failure
Authors: Moses S. Elisaf
Journal: Annals of Internal Medicine (1999)

Letters15 June 1999Increased Serum Lipoprotein(a) Levels in Patients with Early Renal FailureMoses S. Elisaf, MD, Haralampos J. Millionis, MD, and Kostas C. Siamopoulos, MSc, MDMoses S. Elisaf, MDUniversity of Ioannina; Ioannina, Greece (Elisaf)University of Ioannina; Ioannina, Greece (Millionis)University of Ioannina; Ioannina, Greece (Siamopoulos)Search for more papers by this author, Haralampos J. Millionis, MDUniversity of Ioannina; Ioannina, Greece (Elisaf)University of Ioannina; Ioannina, Greece (Millionis)University of Ioannina; Ioannina, Greece (Siamopoulos)Search for more papers by this author, and Kostas C. Siamopoulos, MSc, MDUniversity of Ioannina; Ioannina, Greece (Elisaf)University of Ioannina; Ioannina, Greece (Millionis)University of Ioannina; Ioannina, Greece (Siamopoulos)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-12-199906150-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read with great interest Sechi and colleagues' report (1) on increased serum lipoprotein(a) [Lp(a)] concentration in patients with early renal disease. We have also recently shown that patients with mild to moderate renal failure (n = 106) and creatinine clearance of 10 to 60 mL/min and no factors that influence lipoprotein metabolism (such as proteinuria [>0.5 g/24 h], hypoalbuminemia, glucose intolerance, and severe hyperparathyroidism) exhibit increased serum Lp(a) levels, along with the other more common lipid abnormalities seen in this population (2). In fact, the median serum Lp(a) level was significantly increased in patients compared with levels in ...References1. Sechi LA, Zingaro L, De Carli S, Sechi G, Catena C, Falleti E, et al . Increased serum lipoprotein(a) levels in patients with early renal failure. Ann Intern Med. 1998;129:457-61. LinkGoogle Scholar2. Bairaktari E, Elisaf M, Tsolas O, Siamopoulos KC. Serum Lp(a) levels in patients with moderate renal failure. Nephron. 1998;79:367-8. CrossrefMedlineGoogle Scholar3. Dieplinger H, Lackner C, Kronenberg F, Sandholzer C, Lhotta K, Hoppichler F, et al . Elevated plasma concentrations of lipoprotein(a) in patients with end-stage renal disease are not related to the size polymorphism of apolipoprotein(a). J Clin Invest. 1993;91:397-401. CrossrefMedlineGoogle Scholar4. Kronenberg F, Konig P, Neyer U, Auinger M, Pribasnig A, Lang U, et al . Multicenter study of lipoprotein(a) and apolipoprotein(a) phenotypes in patients with end-stage renal disease treated by hemodialysis or continuous ambulatory peritoneal dialysis. J Am Soc Nephrol. 1995;6:110-20. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Ioannina; Ioannina, Greece (Elisaf)University of Ioannina; Ioannina, Greece (Millionis)University of Ioannina; Ioannina, Greece (Siamopoulos) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoIncreased Serum Lipoprotein(a) Levels in Patients with Early Renal Failure Leonardo A. Sechi , Laura Zingaro , Stefano De Carli , Giovanni Sechi , Cristiana Catena , Edmondo Falleti , Elisabetta Dell'Anna , and Ettore Bartoli Increased Serum Lipoprotein(a) Levels in Patients with Early Renal Failure José J.G. De Lima Increased Serum Lipoprotein(a) Levels in Patients with Early Renal Failure Leonardo A. Sechi , Laura Zingaro , and Ettore Bartoli Metrics 15 June 1999Volume 130, Issue 12Page: 1028KeywordsAttentionCreatinineGlucose intoleranceHyperparathyroidismLipidsLipoprotein metabolismPhenotypesProteinuriaRenal diseasesRenal failure ePublished: 15 August 2000 Issue Published: 15 June 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...