tbuckley/cabot-search huggingface dataset:
From the authors:
Authors: Y. Jegal, D. S. Kim
Journal: European Respiratory Journal (2009)

We thank to H. Chen and co-workers for the interest in our recent paper in the European Respiratory Journal 1, and for raising an important point with good suggestions.

We agree with their opinion, missing data is one of the biggest problems in retrospective studies and we should have discussed this in more detail. However, we still think that the missing data of our study did not markedly influence our results and conclusion 1.

Although there were many missing data in the pulmonary function tests (PFT), the clinical course of most patients were well documented. As stated in our study, 81% of patients had improved or were stable after the initial treatment 1. Although follow-up PFT was variable, as the treatment duration was different for each case, …
Epicardial and endocardial mapping of ventricular tachycardia in patients with myocardial infarction. Is the origin of the tachycardia always subendocardially localized
Authors: WKaltenbrunner, RCardinal, MDubuc, MShenasa, RNadeau, GTremblay, MVermeulen, PSavard, P LPagé
Journal: Circulation (1991)

BACKGROUNDLeft ventricular endocardial reentry is the conventional concept underlying surgery for ventricular tachycardia (VT). We assessed the incidences of patterns showing complete reentry circuits at either the subendocardial or subepicardial level and of patterns in which left ventricular endocardial mapping could only in part account for a reentrant mechanism.METHODS AND RESULTSWe retrospectively analyzed epicardial and left ventricular endocardial isochronal maps of 47 VTs induced in 28 patients with chronic myocardial infarction (inferior, 14 patients; anteroseptal, 14 patients). Electrograms were recorded intraoperatively from 128 sites with epicardial sock and transatrial left ventricular endocardial balloon electrode arrays. Given the methodology used in this study, the mapping characteristics of the tachycardias suggested five types of activation patterns: 1) complete (90% or more of VT cycle length) subendocardial reentry circuits in seven VTs (15%) and seven patients (25%), 2) complete subep...
Changes in vascular capacity in awake dogs in response to carotid sinus occlusion and administration of catecholamines.
Authors: T DBennett, C RWyss, A MScher
Journal: Circulation Research (1984)

Changes in cardiac filling pressure (central venous pressure) were measured following carotid occlusion and infusions of catecholamines in awake dogs while cardiac output was held constant. After carotid occlusion in dogs with vagi blocked, central venous pressure increased about 0.8 mm Hg (an estimated decrease in vascular capacity of 2.4 ml/kg). Carotid occlusion before vagal block or following vagal block and beta-adrenergic block with propranolol caused no significant changes in central venous pressure. Phenylephrine (0.1-2.0 micrograms/min per kg) caused dose-dependent increases in arterial pressure, but changed central venous pressure (ca. 2.5 mm Hg) only at the highest doses. Epinephrine in doses (0.03-0.51 micrograms/min per kg) that caused little change in arterial pressure increased central venous pressure up to 5.3 mm Hg (an estimated decrease in vascular capacity of 12.0 ml/kg); this response was attenuated about 50% by propranolol. Isoproterenol (0.01-0.40 micrograms/min per kg) decreased art...
Development of the Team-Ents (Teamwork in Endoscopy Assessment Module for Endoscopic Non-Technical Skills) Framework
Authors: S Ravindran, R Cavilla, C Healey, M Coleman, H Ashrafian, A Haycock, S Archer, A Darzi, S Thomas-Gibson
Journal: Endoscopy (2021)

Aims Teamworking is crucial to team performance and has been demonstrated to improve the quality and safety of care. Non-technical Skills (NTS) are integral to teamworking and NTS frameworks have been used to support training and assessment in healthcare. The aim of this study was to develop a novel team-based NTS framework in endoscopy – TEAM-ENTS (Teamwork in Endoscopy Assessment Module for Endoscopic Non-Technical Skills).
Accuracy and reproducibility of new M-mode echocardiographic recommendations for measuring left ventricular dimensions.
Authors: M HCrawford, DGrant, R AO'Rourke, M RStarling, B MGroves
Journal: Circulation (1980)

In order to assess the accuracy and reproducibility of the proposed American Society of Echocardiography (ASE) method for measuring left ventricular dimensions on M-mode echocardiograms, we measured the end-diastolic (Dd) and end-systolic (Ds) dimensions by the ASE method and our current technique in 50 normal subjects and 24 patients without coronary artery disease who had symmetrically contracting ventricles on cineangiography. Dd and Ds were significantly greater by the proposed ASE method than by our current technique (p less than 0.001), but the correlation between the two was good (r = 0.93 and 0.83, respectively). In 10 of the normal subjects, the interobserver variability of both methods was excellent. In the 24 patients, the proposed method consistently overestimated the angiographic left ventricular volumes compared with our current technique and occasionally the discrepancies were quite large. Therefore, the proposed ASE method for measuring left ventricular dimensions is not clearly superior t...
Intravenous recombinant tissue-type plasminogen activator in patients with unstable angina pectoris. Results of a placebo-controlled, randomized trial.
Authors: D OWilliams, E JTopol, R MCaliff, RRoberts, G BMancini, J MJoelson, S GEllis, N SKleiman
Journal: Circulation (1990)

Because thrombus formation may contribute to coronary obstruction in patients with unstable angina pectoris, we performed a pilot investigation to determine whether thrombolytic therapy can relieve coronary narrowing in this acute ischemic syndrome. Sixty-seven patients with rest angina and angiographic evidence of coronary stenosis were randomly assigned to receive either low-dose intravenous recombinant tissue-type plasminogen activator (rt-PA) (0.75 mg/kg over 1 hour), high-dose intravenous rt-PA (0.75 mg/kg over 1 hour; total dose, 100 mg over 6 hours), or intravenous placebo followed by repeat coronary angiography at 24-48 hours to assess change in the severity of coronary narrowing. Each patient also received oral aspirin and intravenous heparin. Mean values of coronary stenosis severity (percent of diameter reduction) declined to a similar extent in each group: placebo, 75 +/- 14% to 72 +/- 14% (p = 0.07); low-dose rt-PA, 75 +/- 16% to 71 +/- 18% (p = 0.03), and high-dose rt-PA, 82 +/- 11% to 77 +/...
Endoscopic Ultrasound-Guided Gastroenteric Anastomosis: A French Center Experience
Authors: S Ouazzani, A Becar, M Gasmi, M Barthet, J-M Gonzalez
Journal: Endoscopy (2021)

Aims Endoscopic ultrasound-guided gastroenteric anastomosis (EUS-GEA) is a minimally invasive alternative to surgery in the treatment gastric outlet obstruction. We aim to present a single center cohort highlighting the rate of benign indications and management of stent dislodgement.
Rock Inhibitor Fasudil Reduces Leukocyte-Endothelium Interactions in the Microvasculature of a Sickle Cell Mouse Model of Allergic Inflammation
Authors: Athos Rodrigues Moraes, Hanan Chweih, Nicola Conran, Kleber Yotsumoto Fertrin, Fernando Ferreira Costa, Carla Fernanda Franco-Penteado
Journal: Blood (2017)
Optimal detection of the progression of coronary artery disease: comparison of methods suitable for risk factor intervention trials.
Authors: SEllis, WSanders, CGoulet, RMiller, K CCain, JLesperance, M GBourassa, E LAlderman
Journal: Circulation (1986)

To assess the best method of quantitating progression of coronary disease, we studied four measurements in 114 coronary segments from 35 medically treated patients from whom angiograms were obtained 5 years apart. Only stenoses of less than 70% that were visualized in nearly identical projections on both angiograms were evaluated. Vessel edges were measured by use of catheter calibration and an automated computer algorithm yielding two absolute dimensions (mean and minimum diameters) and two measurements (percent stenosis and atheroma area) that required a normal reference diameter. The coefficient of variation for repeated segment measurements was less for mean and minimum diameter than for percent stenosis and area of atheroma. The best measure of progression of coronary disease as determined by t test comparison of different methods was the change in mean diameter over time (6.7 +/- 14.1% decrease), whether calculated on a per coronary segment or per patient basis (p less than .001). Based on this ...
Age-Adjusted D-Dimer Cutoff Levels and Pulmonary Embolism
Authors: Giorgio Colombo, Ludovico Furlan, Giulia Colombo
Journal: JAMA (2014)

To the Editor The study by Dr Righini and colleagues1 validated the use of an age-adjusted D-dimer cutoff level to rule out pulmonary embolism. The 6 different D-dimer assays used in the study were demonstrated to be equivalent in a previous meta-analysis.2
Vascular bound recombinant extracellular superoxide dismutase type C protects against the detrimental effects of superoxide radicals on endothelium-dependent arterial relaxation.
Authors: TAbrahamsson, UBrandt, S LMarklund, P OSjöqvist
Journal: Circulation Research (1992)

Extracellular superoxide dismutase type C (EC-SOD C) is a secretory SOD isoenzyme that, in vivo, is bound to heparan sulfate proteoglycans in the glycocalyx of various cell types (e.g., endothelial cells) and in the connective tissue matrix. The aim of this study was to investigate the efficacy of vascular bound EC-SOD C in protecting arterial relaxation mediated by endothelium-derived relaxing factor (EDRF) against the inhibitory effects of superoxide radicals. For comparison, the effect of CuZn SOD was also studied. This SOD isoenzyme lacks affinity toward heparan sulfate and does not bind to cell surfaces. Rings from rabbit aorta were mounted in an organ bath and acetylcholine-induced endothelium-dependent relaxation was then studied in preparations precontracted with phenylephrine. Pyrogallol (10(-4) M), used to generate superoxide radicals, reduced the maximal relaxant effect of acetylcholine from about 65% to 25%. When present in the buffer throughout the experiment, CuZn SOD and EC-SOD C caused a c...
Return of normal conduction after paroxysmal heart block. Report of a case with major discordance of electrophysiological and pathological findings.
Authors: K MRosen, DWu, CKanakis, PDenes, SBharati, MLev
Journal: Circulation (1975)

This report describes a 52-year-old male with paroxysmal heart block as well as left and right bundle branch block, resulting in Stokes-Adams attacks. The patient experienced a return to 1:1 atrioventricular (A-V) conduction with narrow QRS within 48 hours of the attacks and heart block never recurred. Electrophysiological studies three weeks later revealed a narrow QRS, a normal H-V interval (36 msec), 1:1 A-V conduction up to an atrial paced rate of 210 beats/min, and normal refractory periods with atrial extrastimulus techniques (His-Purkinje system refractory periods less than 370 msec). The patient died from a cerebral embolus incurred during diagnostic left heart catheterization two days after electrophysiological studies. Postmortem examination revealed calcific aortic stenosis with calcific impingement upon the pars membranacea resulting in compression of the distal His bundle and marked disruption of the proximal portions of both bundle branches. This report documents a major limitation of electr...
Reply to Thoufeeq
Authors: Tae Kim, Jeong-Seon Ji, Hwang Choi
Journal: Endoscopy (2014)

Unfortunately, we did not carry out cost analysis in our study. Luigiano et al. [1] reported that endoclip-assisted polypectomy is much more expensive than the endoloop-assisted procedure. In their paper, the cost of the technique with loops was € 86.2 per patient, whereas that of the technique with clips was € 297.3. However, the clip technique resulted in several patients avoiding colon resection and the associated increase in surgical risks and costs.
Surface recording of His-Purkinje activity on an every-beat basis without digital averaging.
Authors: N CFlowers, VShvartsman, B MKennelly, G SSohi, L GHoran
Journal: Circulation (1981)

Efforts to record evidence of electrical activity from the body surface originating in the His bundle or bundle branches have been reported since 1973. Almost exclusively, these techniques have required digital averaging of 50-100 sequential cardiac cycles. For immediate diagnostic, therapeutic and prognostic application, recording on an every-beat basis is highly desirable. This is especially important in instances of changing atrioventricular conduction, arrhythmias or less-than-constant RR intervals. Our object has been to develop a system for more nearly optimal noise reduction, to avoid the disadvantages of serial signal averaging, and to be able to record His-Purkinje activity in man on an every-beat basis. Using multiple parallel inputs wih linear amplification, additional logarithmic amplification, some bandpass filtering, and a logic circuit that ultimately examines and accepts or rejects a deflection as true signal, we can record, in most instances, on a beat-by-beat basis, this very valuable ...
Coronary arterial thrombolysis with combined infusion of recombinant tissue-type plasminogen activator and urokinase in patients with acute myocardial infarction.
Authors: E JTopol, R MCaliff, B SGeorge, D JKereiakes, DRothbaum, R JCandela, C WAbbotsmith, C APinkerton, D CStump, DCollen
Journal: Circulation (1988)

To determine whether tissue-type plasminogen activator (t-PA) and urokinase (UK) act synergistically to achieve coronary thrombolysis, incremental doses of both drugs were infused intravenously over 60 min. In 146 consecutive patients treated 3.0 +/- 1.0 hr from symptom onset, coronary angiography was performed 90 min after the start of the infusion and at 7 days. The groups of patients treated by different dose regimen were as follows: group I, 14 patients treated with t-PA 25 mg and UK 0.5 million U; group II, 20 patients given t-PA 25 mg and UK 1.0 million U; group III, 24 patients given t-PA 1.0 mg/kg and UK 0.5 million U; group IV, 33 patients treated with t-PA 1.0 mg/kg and UK 1.0 million U; and group V, 55 patients given t-PA 1.0 mg/kg and UK 2.0 million U. In groups I and II, patency of the infarct-related vessel at 90 min was only 36% and 42%, respectively. With 1 mg/kg t-PA and increasing doses of UK (groups III to V), patency ranged from 72% to 75% (overall 73%). Repeat catheterization at 7 day...
52P Genetic and clinical profiling of a cohort of extended small cell lung carcinoma
Authors: E.M. Vida Navas, J. Chamorro Pérez, E. Corral de la Fuente, Y. Lage, A. Gómez Rueda, J. Torres Jiménez, L. Sanz Gómez, J.J. Soto Castillo, P. Álvarez Ballesteros, J. Esteban Villarrubia, V. Albarrán Fernández, D.I. Rosero Rodríguez, M. San Román Gil, J. Pozas Pérez, M. Lario, A. Caminoa Lizarralde, P. Garrido Lopez, M.E. Olmedo García
Journal: Journal of Thoracic Oncology (2021)
Absolute determination of cardiac output in intra-aortic balloon pumped patients using the radial arterial pressure trace.
Authors: G AHerzlinger
Journal: Circulation (1976)

We describe a new method for the absolute determination of cardiac output in intra-aortic balloon pumped (IABP) patients. The method uses the known pumping volume of the IABP balloon and the radial arterial pressure trace, which is commonly used to monitor IABP patients, to determine the cardiac output. Two pressure excursions denoted by P1-P0 and P2-P0, characterizing IABP balloon deflation, and ventricular ejection, respectively, are extracted from the radial trace. The cardiac output (CO) is then determined by the simple relation: CO = (BV) x (P2-P0)/(P1-P0) x HR where HR is the heart rate, and the value for pumped balloon volume (BV) is corrected for the effect of the pressure in the patient's aorta. Comparison with dye dilution and thermal dilution procedures as carried out on a routine basis in a clinical setting produced a good correlation (r = .928). When fit to a straight line through zero output, the data yielded a constant of proportionality of 0.973 between the above formula and the clinical p...
Abstract 17077: Functional Class, Biomarker Stability, and Clinical Outcomes of Patients With Transthyretin Cardiac Amyloidosis Treated With Tafamidis
Authors: Pranav Chandrashekar, Zack Dale, Lana Rashdan, Miriam Elman, Babak Nazer, Stephen B Heitner, Ahmad Masri
Journal: Circulation (2020)

Introduction: Tafamidis has been shown to improve survival and decrease heart failure (CHF) hospitalizations in transthyretin cardiac amyloidosis (ATTR-CM). In the ATTR-ACT trial, survival benefit emerged after approximately 18 months of treatment, with less clear benefit in those with NYHA class III symptoms. We sought to evaluate the short-term changes in NYHA class, biomarkers, and clinical outcomes in a real-world cohort of patients treated with tafamidis. Methods: A single center retrospective observational study of patients with ATTR-CM who were prescribed tafamidis since its FDA approval in May 2019. We collected data on prospectively assessed NYHA class, NTproBNP, Troponin I, and outcomes of CHF hospitalizations and death. Results: Fifty-one patients with ATTR-CM (mean age 73.3±7 years, 100.0% male) were prescribed tafamidis. Forty-five patients had wild-type and 6 had hereditary ATTR-CM. At the visit when tafamidis was initiated 6 (11.8%) patients were NYHA Class I, 24 (47.1%) Class II, 20 (39.2%) Class III, and 1 (2%) Class IV. Over a median follow up of 8 (IQR 6.0-11) months after starting tafamidis, there were no significant differences before and after tafamidis treatment in time-averaged median NYHA functional class (paired Wilcoxon test, p=0.1610; Figure 1A), time-averaged median NTproBNP (paired exact Wilcoxon test, p &gt; 0.9999; Figure 1B), and time-averaged median troponin I (paired exact Wilcoxon test, p=0.9400; Figure 1C). Following initiation of tafamidis, 13 patients (25.5%) were admitted for CHF hospitalization. A total of 8 patients (15.7%) died a median of 9.5 (IQR 2.5-12.5) months after initiation of tafamidis. Conclusions: ATTR-CM patients taking tafamidis were observed to have stable functional status and biomarkers, including those with NYHA class III symptoms. Despite a higher proportion of worse NYHA functional class, the rate of death at 10 months appears comparable to the ATTR-ACT trial in this real-world population.
Aortic infarction following dissecting aortic aneurysm.
Authors: S HBarsky, SRosen
Journal: Circulation (1978)

Aortic infarction was observed in 21 of 34 cases of dissecting aortic aneurysm. This lesion occurred as a central zone of necrosis with preserved elastic laminae, sparing media adjacent to the true and false lumens. In cases where the false lumen was occluded, the central infarction extended to this lumen. The infarction followed rather than preceded dissection, took approximately 48 hours to develop, and did not organize with time. The lesion occurred exclusively in the thoracic aorta, and bore no relationship to medial cystic necrosis. Present surgical therapy does not extirpate these areas, and the implication of these lesions in terms of management remains to be determined.
The spontaneous occurrence of paroxysmal supraventricular tachycardia.
Authors: E LPritchett, M SSmith, E AMcCarthy, K LLee
Journal: Circulation (1984)

The seemingly unpredictable occurrence of paroxysmal supraventricular tachycardia has impeded understanding of its clinical course. We documented recurring tachycardia by telephone transmission of the electrocardiogram in 14 patients and measured the   between the start of therapy and the first recurrence of tachycardia and between successive recurrences. We showed that attacks of tachycardia were clinically independent by calculating the autocorrelation function for 12 to 14 consecutive tachycardia-free periods. We also found that the periods between attacks closely fit an exponential probability distribution, indicating that the occurrence of tachycardia in time was a type of random event called a Poisson process. Furthermore, occurrence of tachycardia was uniformly distributed throughout a dosing interval; there was no predilection for tachycardia to occur late in a dosing interval when plasma drug levels were presumed to be lowest. Measuring the tachycardia-free period is a si...
Nm23-H1 mediates metastasis suppression through the receptors Edg2 and c-Met in MDA-MB-435 cells
Authors: Christine E. Horak, Jong Heun Lee, Abdel Elkahoun, Diane Palmieri, Douglas O. Halverson, Paul Meltzer, Patricia S. Steeg
Journal: Cancer Research (2006)

4307  Diminished expression of the metastasis suppressor Nm23-H1 significantly correlates with tumor aggressiveness in breast cancer. exogenous overexpression of Nm23-H1 in the metastatic breast carcinoma cell line MDA-MB-435 reduces the metastatic capacity of these cells as determined by in vivo mouse injection experiments and in vitro assays of cell motility and soft agar colonization. Mutational analysis of Nm23-H1 has revealed that substitution mutants P96S and S120G are unable to inhibit cell motility and colonization. To elucidate the molecular mechanism by which Nm23-H1 mediates metastasis suppression, we performed microarray expression analysis using a comprehensive oligonucleotide array and mRNA extracted from MDA-MB-435 cells stably overexpressing wild-type Nm23-H1 and the P96S and S120G mutants as compared to a control-transfected cell line. The data revealed that 84 genes are down-regulated upon overexpression of wild-type Nm23-H1 and 103 genes are up-regulated (p  0.23). Approximately 70 genes are specifically regulated by wild-type Nm23-H1, but not by the mutants. Presumably, these genes are critical to metastatic suppression and they include the down-regulated genes c-MET, PTN, L1CAM, FZD1 and EDG2 and the up-regulated genes SPP1 and GA17. Using quantitative RT-PCR and immunoblot analysis, we have confirmed the observed patterns of microarray expression in approximately 90% of the genes tested. We have determined the relevance of the relationship between Nm23-H1 and its regulated genes in clinical breast cancer specimens through analysis of published microarray data of two tumor cohorts. Within these datasets, a significant correlation has been established between expression of the Nm23-H1 gene and expression of twenty genes that it regulates, including c-MET, PTN, FZD1 and EDG2 (p
Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart.
Authors: MUngerer, GParruti, MBöhm, MPuzicha, ADeBlasi, EErdmann, M JLohse
Journal: Circulation Research (1994)

The beta-adrenergic receptor system of the failing human heart is markedly desensitized. We have recently postulated that this desensitization may in part be caused by an increase in beta-adrenergic receptor kinase (beta ARK) expression. beta ARK is thought to effect desensitization by acting in concert with an inhibitor protein, called beta-arrestin. Two isoforms have been identified both for beta ARK and for beta-arrestin. In the present study, we have investigated the expression of the individual isoforms of beta-arrestin and of beta ARK in left ventricles from failing and control human hearts. mRNAs for all four proteins, beta-arrestin-1, beta-arrestin-2, beta ARK-1, and beta ARK-2, were identified in human heart. Quantitation by reverse-transcription polymerase chain reactions showed that in heart failure there were no changes of the mRNA levels for beta-arrestin-1 and beta-arrestin-2, a slight (< 50%) increase of the mRNA for beta ARK-2, and a threefold increase for beta ARK-1 mRNA. At the protein l...