Effects of Low-Carbohydrate and Low-Fat Diets
Authors: Gaetano Santulli
Journal: Annals of Internal Medicine (2015)

Letters3 March 2015Effects of Low-Carbohydrate and Low-Fat DietsGaetano Santulli, MD, PhDGaetano Santulli, MD, PhDFrom Columbia University Medical Center College of Physicians and Surgeons, New York, New York.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-5057-3 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their randomized trial, Bazzano and colleagues (1) report that a low-carbohydrate diet is more effective for weight loss than a low-fat diet. Of note, such a difference was significant (P < 0.001) at 3- and 6-month follow-up but was no longer obvious (P > 0.001) after 1 year. A recent meta-analysis revealed a similar pattern (2); of interest, when comparing the 2 diets at 12-month follow-up, such variables as the 10-year Framingham Risk Score and high-density lipoprotein cholesterol levels differed significantly but remarkably did not differ at 3-month follow-up (P > 0.001) (1). The original Framingham Study revealed that ...References1. Bazzano LA, Hu T, Reynolds K, Yao L, Bunol C, Liu Y, et al. Effects of low-carbohydrate and low-fat diets: a randomized trial. Ann Intern Med. 2014;161:309-18. [PMID: 25178568]. doi:10.7326/M14-0180 LinkGoogle Scholar2. Nordmann AJ, Nordmann A, Briel M, Keller U, Yancy WS, Brehm BJ, et al. Effects of low-carbohydrate vs low-fat diets on weight loss and cardiovascular risk factors: a meta-analysis of randomized controlled trials. Arch Intern Med. 2006;166:285-93. [PMID: 16476868] CrossrefMedlineGoogle Scholar3. Castelli WP, Garrison RJ, Wilson PW, Abbott RD, Kalousdian S, Kannel WB. Incidence of coronary heart disease and lipoprotein cholesterol levels The Framingham Study. JAMA. 1986;256:2835-8. [PMID: 3773200] CrossrefMedlineGoogle Scholar4. Bønaa KH, Thelle DS. Association between blood pressure and serum lipids in a population The Tromsø Study. Circulation. 1991;83:1305-14. [PMID: 2013148] CrossrefMedlineGoogle Scholar5. Yuhanna IS, Zhu Y, Cox BE, Hahner LD, Osborne-Lawrence S, Lu P, et al. High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase. Nat Med. 2001;7:853-7. [PMID: 11433352] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Columbia University Medical Center College of Physicians and Surgeons, New York, New York.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOf InterestForms.do?msNum=L14-0507. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffects of Low-Carbohydrate and Low-Fat Diets Lydia A. Bazzano , Tian Hu , Kristi Reynolds , Lu Yao , Calynn Bunol , Yanxi Liu , Chung-Shiuan Chen , Michael J. Klag , Paul K. Whelton , and Jiang He Effects of Low-Carbohydrate and Low-Fat Diets Lydia A. Bazzano , Tian Hu , Kristi Reynolds , Lu Yao , Calynn Bunol , Yanxi Liu , Chung-Shiuan Chen , Michael J. Klag , Paul K. Whelton , and Jiang He Effects of Low-Carbohydrate and Low-Fat Diets Stephen F. Burns and Masashi Miyashita Effects of Low-Carbohydrate and Low-Fat Diets Alberto Donzelli and Alessandra Lafranconi Effects of Low-Carbohydrate and Low-Fat Diets Murray Skeaff , Jim Mann , Lisa Te Morenga , and Rachael McLean Effects of Low-Carbohydrate and Low-Fat Diets Lydia A. Bazzano and Tian Hu Effects of Low-Carbohydrate and Low-Fat Diets Alberto Donzelli and Alessandra Lafranconi Effects of Low-Carbohydrate and Low-Fat Diets Stephen F. Burns and Masashi Miyashita Effects of Low-Carbohydrate and Low-Fat Diets Lydia A. Bazzano and Tian Hu Effects of Low-Carbohydrate and Low-Fat Diets Murray Skeaff , Jim Mann , Lisa Te Morenga , and Rachael McLean Metrics Cited ByRegulation of Sphingolipid Metabolism by MicroRNAs: A Potential Approach to Alleviate AtherosclerosisLong Noncoding RNAsAdrenergic ReceptorsSympathetic Nervous System Signaling in Heart Failure and Cardiac AgingmicroRNAs Distinctively Regulate Vascular Smooth Muscle and Endothelial Cells: Functional Implications in Angiogenesis, Atherosclerosis, and In-Stent RestenosisMechanistic Role of MicroRNAs in Coupling Lipid Metabolism and Atherosclerosis 3 March 2015Volume 162, Issue 5Page: 392KeywordsConflicts of interestDietDisclosureHypertensionObesityStable coronary artery diseaseWeight loss ePublished: 3 March 2015 Issue Published: 3 March 2015 CopyrightCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...