tbuckley/cabot-search huggingface dataset:
ENTEROSCOPY-ASSISTED ERCP FOR TREATMENT OF PANCREATIC PSEUDOCYST AND STRICTURE: A CASE REPORT
Authors: E. Cho, C.H. Park, S.Y. Cho
Journal: Endoscopy (2022)

Aims Endoscopic treatment of pancreatic pseudocyst in patients with altered anatomy is challenging. The aim of this study is to prove the efficacy and safety of enteroscopy-assisted ERCP for the treatment of pancreatic pseudocyst and stricture in a patient with extrahepatic cholangiocarcinoma after pylorus-preserving pancreaticoduodenectomy.
COMPUTER AIDED DIAGNOSIS FOR THE CHARACTERISATION OF DYSPLASIA IN BARRETT’S ESOPHAGUS WITH MAGNIFICATION ENDOSCOPY ON I-SCAN IMAGING
Authors: M. Hussein, D. Lines, J. González-Bueno Puyal, N. Bowman, V. Sehgal, D. Toth, M. Everson, O. Ahmad, R. Kader, J.M. Esteban, R. Bischopps, M. Banks, M. Haefner, P. Mountney, D. Stoyanov, L. Lovat, R. Haidry
Journal: Endoscopy (2022)

Aims We aimed to develop a computer aided detection system that can support the diagnosis of Barrett's oesophagus (BE) dysplasia on magnification endoscopy.
FELLOW EXPERIENCES WITH ENDOSCOPY SIMULATION BEFORE AND DURING THE COVID-19 PANDEMIC: AN INTERNATIONAL SURVEY
Authors: B. Lee, E. Lin, N. Karnik, R. Williams, V. Popov, I. Boskovski, M. Maida, P. Gkolfakis, M. Arvanitakis, A. Ong Ming Liang, M.A. De Lusong, S. Vignesh
Journal: Endoscopy (2022)

Aims We aimed to evaluate the current state of endoscopy training internationally in the wake of the pandemic as perceived by trainees.
ENDOSCOPIC ULTRASOUND-GUIDED DRAINAGE OF PERIRECTAL ABSCESS IN PYODERMA GANGRENOSUM
Authors: M. Gesualdo, M. Sacco, F. Castellano, A. Mauriello, F. Fimiano, F. Cravero, C.G. De Angelis
Journal: Endoscopy (2022)

The video presents a case of 47-year-old woman with a perirectal abscess (64 mm at MRI) in pyoderma gangrenosum, with symptomatic onset of fever and sacral pain. Blood test detected high serum level of WBC (18.000/mmc) and mild level of C-reactive protein (9 mg/dl). Endoscopic ultrasound-guided drainage of collection was planned.
EUS-GUIDED PORTAL PRESSURE GRADIENT MEASUREMENT (EUS-PPG). PRELIMINARY RESULTS COMPARED WITH HEPATIC VENOUS PRESSURE GRADIENT (HVPG)
Authors: B. Martínez-Moreno, L. Guilabert, J. Martínez, A. Hurtado, S. Pascual, M. Rodríguez, C. Miralles, I. Herrera, P. Bellot, J. Martínez-Sempere, L. Compañy, F. Ruiz, C. Mangas, J.R. Aparicio
Journal: Endoscopy (2022)

Aims Evaluate technical success and related complications associated to EUS-GPP in cirrhotic patients. Secondary endpoint: explore the correlation between EUS-PPG and HVPG in cirrhotic patients.
UPPER DIGESTIVE HEMORRHAGE: CLINICAL, ENDOSCOPIC AND EVOLUTIONARY PARTICULARITIES BETWEEN PATIENTS WITH COMMUNITY AND INTRA-HOSPITAL HEMORRHAGE, PROSPECTIVE STUDY
Authors: A. Touibi, A. Benhamdane, T. Addajou, S. Rokhsi, A. Sair, S. Mrabti, R. Berraida, I. El Koti, F. Rouibaa, A. Benkirane, H. Seddik
Journal: Endoscopy (2022)

Aims The aim of this study is to compare the clinical, endoscopic and evolutionary particularities between patients with community and intra-hospital hemorrhage.
LONG-TERM OUTCOMES AFTER EUS-GUIDED PANCREATIC DUCT DRAINAGE
Authors: M. Van Haren, T. Aouattah, T. Moreels, R. Yeung, P.H. Deprez
Journal: Endoscopy (2022)

Methods For this retrospective single tertiary-referral center study, data from patients with EUS-PD were collected in patient’s charts and the endoscopy database, retrieving information on indication, technique of drainage, technical and clinical successes (total in case of no pain after treatment, and partial if more than 50% reduction in pain), adverse events, as well as reasons for failure defined as no improvement of (pain) symptoms, or need for surgery.
ENDOSCOPIC ULTRASOUND (EUS) GUIDED COLORECTAL ANASTOMOSIS FOR SUCCESSFUL RELIEF OF MALIGNANT ADHESIVE LEFT SIDED COLONIC OBSTRUCTION IN A CASE OF FAILED COLONIC STENTING
Authors: A. Gandhi, J. Ansari, H. Raina, S. Bhagwat, H. Bapaye, R. Pujari, T. Nikumbh, A. Bapaye
Journal: Endoscopy (2022)

53-y-female,Primary Peritoneal Carcinomatosis–sigmoid colectomy(2017),right hemi-colectomy(2020) for tumour de-bulking and relief of recurrent obstruction,multiple chemotherapy cycles. Complaints–distal large bowel obstruction at rectosigmoid-peritoneal adhesions, CECT–dilated large colon,adhesive obstruction at rectosigmoid–failed colonic stenting due to sharp angulation & failed guidewire cannulation. Linear EUS and fluoroscopy–apposed dilated colonic segment. Contrast injected into obstructed bowel-19G needle. Colorectal anastomosis using hot lumen apposing metal stent(LAMS;20mmX10mm). 7Fr catheter through LAMS for saline irrigation,lactulose enema. Immediate decompression with symptomatic relief. X-ray–significant decompression. Oral diet resumed after 2 days.Sigmoidoscopy after 72hours–LAMS in situ,draining faeces, irrigation catheter removed.Discharged 3 days later.No complications.Asymptomatic-3-weeks f/u.
93MO Optimal 18F-FDG PET/CT (FDG-PET) cut-off for pathological complete response (pCR) prediction in HER2-positive [HER2+] early breast cancer (EBC) patients (pts) treated with neoadjuvant trastuzumab (T) and pertuzumab (P) in PHERGain trial
Authors: G. Gebhart, M. Keyaerts, T. Guiot, P. Flamen, M. Ruiz Borrego, A. Stradella, B. Bermejo De Las Heras, S. Escriva de Romani, L. Calvo-Martinez, N. Ribelles Entrena, N. Martinez, C.R. Albacar Miro, M.A. Colleoni, M. Atienza de Frutos, M. Sampayo-Cordero, J. Cortés, J.M. Perez Garcia, A. Llombart Cussac
Journal: Annals of Oncology (2022)
Heterostructured Metal–Organic Frameworks/Polydopamine Coating Endows Polyetheretherketone Implants with Multimodal Osteogenicity and Photoswitchable Disinfection
Authors: Yi Deng, Jiacheng Shi, Yau Kei Chan, Ding Bai, Rui Shu, Xiuyuan Shi, Yunfei Li, Limei Li, Xiao Yang, Weizhong Yang
Journal: Advanced Healthcare Materials (2022)

Abstract Clinically, bacteria‐induced contagion and insufficient osseointegrative property inevitably elicit the failure of orthopedic implants. Herein, a heterostructured coating consisting of simvastatin (SIM)‐laden metal–organic frameworks and polydopamine nanolayers is created on a porous bioinert polyetheretherketone implant. The heterostructured coating significantly promotes cytocompatibility and osteogenic differentiation through multimodal osteogenicity mechanisms of zinc ion (Zn 2+ ) therapy, SIM drug therapy, and surface micro‐/nano‐topological stimulation. Under the illumination of near‐infrared (NIR) light, singlet oxygen ( 1 O 2 ) and local hyperthermia are produced; besides, NIR light dramatically accelerates the release of Zn 2+ ions from heterostructured coatings. Gram‐positive and ‐negative bacteria are effectively eradicated by the synergy of photothermal/photodynamic effects and photo‐induced accelerated delivery of Zn 2+ ions. The superior osteogenicity and osseointegration, as well as photoswitchable disinfection controlled by NIR light are corroborated via in vivo results. This work highlights the great potential of photoresponsive heterostructured orthopedic implants in treatment of the noninvasive bone reconstruction of bacteria‐associated infectious tissues through multimodal phototherapy and photoswitchable ion‐therapy.
Deepm5C: A deep-learning-based hybrid framework for identifying human RNA N5-methylcytosine sites using a stacking strategy
Authors: Md Mehedi Hasan, Sho Tsukiyama, Jae Youl Cho, Hiroyuki Kurata, Md Ashad Alam, Xiaowen Liu, Balachandran Manavalan, Hong-Wen Deng
Journal: Molecular Therapy (2022)

As one of the most prevalent post-transcriptional epigenetic modifications, N5-methylcytosine (m5C) plays an essential role in various cellular processes and disease pathogenesis. Therefore, it is important accurately identify m5C modifications in order to gain a deeper understanding of cellular processes and other possible functional mechanisms. Although a few computational methods have been proposed, their respective models have been developed using small training datasets. Hence, their practical application is quite limited in genome-wide detection. To overcome the existing limitations, we propose Deepm5C, a bioinformatics method for identifying RNA m5C sites throughout the human genome. To develop Deepm5C, we constructed a novel benchmarking dataset and investigated a mixture of three conventional feature-encoding algorithms and a feature derived from word-embedding approaches. Afterward, four variants of deep-learning classifiers and four commonly used conventional classifiers were employed and trained with the four encodings, ultimately obtaining 32 baseline models. A stacking strategy is effectively utilized by integrating the predicted output of the optimal baseline models and trained with a one-dimensional (1D) convolutional neural network. As a result, the Deepm5C predictor achieved excellent performance during cross-validation with a Matthews correlation coefficient and an accuracy of 0.697 and 0.855, respectively. The corresponding metrics during the independent test were 0.691 and 0.852, respectively. Overall, Deepm5C achieved a more accurate and stable performance than the baseline models and significantly outperformed the existing predictors, demonstrating the effectiveness of our proposed hybrid framework. Furthermore, Deepm5C is expected to assist community-wide efforts in identifying putative m5Cs and to formulate the novel testable biological hypothesis.
PARTICULAR FEATURES OF COLORECTAL POLYPS IN THE ELDERLY: HOW DO THEY DIFFER FROM THE YOUNG?
Authors: S. Rokhsi, S. Mrabti, T. Addajou, A. Benhamdane, A. Touibi, A. Sair, R. Berrida, I. El koti, F. Rouibaa, A. Benkirane, H. Seddik
Journal: Endoscopy (2022)

Aims The aim is to evaluate the differences between older and younger patients regarding the incidence of colorectal polyps, their endoscopic characteristics and the overall complication rate after resection.
THE CONTRIBUTION OF ENDOSCOPIC ULTRA SONOGRAPHY IN AMPULLARY PATHOLOGY
Authors: M. El Mountassir, M. Borahma, I. Benelbarhdadi, F. Chabib, N. Lagdali, C. Berhili, F. Ajana
Journal: Endoscopy (2022)

Methods This was a study spanning a 2-year period during which 09 patients were identified.We evaluated tumor size, tumor wall staging, pancreatic and biliary impact, tumor echogenicity, vascular relationships and the presence of lymphadenopathy.
MOTORIZED SPIRALED ENTEROSCOPY: EFFICACY AND SAFETY A. SPORTES, GHARBI, J-F REY INSTITUT ARNAULT TZANCK -SAINT LAURENT DU VAR -FRANCE
Authors: A. Sportes
Journal: Endoscopy (2022)

Aims AIM: Motorized spired Enteroscopy (MSE) is a new equipment developed by Olympus (Power spiral) in order to improve small bowel exploration. It’s a modify version with a motor from the initial manual spiraled enteroscope the goal of our study was to assess its efficacy and safety on clinical practice
FEASIBILITY AND SAFETY OF A NOVEL OVER-THE-SCOPE DEVICE TO FACILITATE ENDOSCOPIC ARGON PLASMA COAGULATION – AN EX-VIVO STUDY
Authors: J. Mueller, G. Kayser, A. Kuellmer, D. Bettinger, M. Schiemer, F. Offensperger, T. Robert, A. Schmidt
Journal: Endoscopy (2022)

Aims Argon plasma coagulation (APC) is an electrosurgical procedure used for various indications in the gastrointestinal tract, such as ablation of dysplastic Barrett’s mucosa. Homogeneous and safe application can be compromised by varying distances and suboptimal angle of the probe to the tissue. The Argon Precision Cap is a novel endoscopic device developed to optimize endoluminal APC treatment. Objectives of this study were to assess feasibility and safety and to determine suitable APC settings for tissue ablation in the esophagus.
CNS non-germinomatous germ cell tumor (NGGCT): Lessons from the recent past
Authors: Kee Kiat Yeo, Shannon M MacDonald
Journal: Neuro-Oncology (2022)

Central nervous system (CNS) germ cell tumors (GCT) are a rare heterogenous group of malignant tumors that commonly arise in children, adolescents, and young adults. These tumors account for approximately 3%-5% of all primary pediatric CNS tumors in North America, with a higher incidence reported in certain parts of Asia.1,2 CNS GCTs are classified based on their histological appearance and immunohistochemical profile and are divided into germinoma and non-germinomatous germ cell tumors (NGGCTs), with the latter rarer and more challenging to treat. Through numerous prospective clinical trials across the globe, the treatment of CNS GCT has steadily advanced with improvement in outcomes.3,4 However, a universally accepted standard-of-care treatment for these tumors remains elusive, with varied diagnostic criteria and treatment regimens employed between oncologist in the United States/Canada (Children’s Oncology Group [COG]), Europe (International Society of Pediatric Oncology [SIOP]), and in Asia. Unfortunately, a significant proportion of patients with CNS NGGCT either do not respond to treatment or suffer disease recurrence during/following completion of therapy.5 With the noted variance in treatment approaches, coupled with the relative rarity of this disease, there is a paucity of data in the literature describing the pattern of disease recurrence and treatment failure.
Immune-awakening Saccharomyces-inspired nanocarrier for oral target delivery to lymph and tumors
Authors: Yuling Mao, Xiudan Wang, Caishun Chen, Qinfu Zhao, Yanfeng Liu, Jinghai Zhang, Siling Wang
Journal: Acta Pharmaceutica Sinica B (2022)

Utilization of the intestinal lymphatic pathway will allow extraordinary gains in lymph and tumors cascade-targeted delivery of oral drugs and awakening the innate/adaptive immunity of the body and the lesion microenvironment, in addition to improving oral bioavailability relative to other means of delivery of oral drugs. Here, inspired by the specific invasion route of intestinal microorganisms, we pioneered an immune-awakening
188P Pooled analysis of two phase II randomised studies (NorBreast-231 &amp; TEMPO Breast) evaluating weekly oral vinorelbine (VNR) as first-line chemotherapy in patients with hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC)
Authors: G. Freyer, L. Collet, R. Raymond, C. Ta Thanh Minh, M.S. Aapro
Journal: Annals of Oncology (2022)
126P Usefullness of perforator flaps in breast cancer: A single-centre clinical audit from India
Authors: C.B. Koppiker, S. Joshi, R. Mishra, D. Kelkar, A. Joshi, J. John, S. Kadu, N. Gupta, N. Gangurde, G.K. Sharan, U. Dhar, H. Allampati, L. Busheri, S. Nare, A. Dewle, D. Thakkar, C. Guduru
Journal: Annals of Oncology (2022)
Molecular Mechanisms of Iron and Heme Metabolism
Authors: Sohini Dutt, Iqbal Hamza, Thomas Benedict Bartnikas
Journal: Annual Review of Nutrition (2022)

An abundant metal in the human body, iron is essential for key biological pathways including oxygen transport, DNA metabolism, and mitochondrial function. Most iron is bound to heme but it can also be incorporated into iron-sulfur clusters or bind directly to proteins. Iron's capacity to cycle between Fe2+ and Fe3+ contributes to its biological utility but also renders it toxic in excess. Heme is an iron-containing tetrapyrrole essential for diverse biological functions including gas transport and sensing, oxidative metabolism, and xenobiotic detoxification. Like iron, heme is essential yet toxic in excess. As such, both iron and heme homeostasis are tightly regulated. Here we discuss molecular and physiologic aspects of iron and heme metabolism. We focus on dietary absorption; cellular import; utilization; and export, recycling, and elimination, emphasizing studies published in recent years. We end with a discussion on current challenges and needs in the field of iron and heme biology.
HYBRID SUBMUCOSAL ENDOSCOPIC EXCAVATION FOR A GASTRIC GIST IN A PATIENT WITH A VOLUMINOUS ABDOMINAL WALL HERNIA – KILLING TWO FLIES WITH ONE BLOW
Authors: F. Pereira Correia, B. Pinto, M. Cardoso, J.C. Branco, L. Carvalho Lourenço, A. Martins
Journal: Endoscopy (2022)

A 60-years-old male followed by General Surgery for irreducible voluminous incisional hernia. He had a history of gastric polypoid lesion not fully characterized, so an upper GI endoscopy were requested prior to hernia surgical repair. Upper GI endoscopy and endoscopic ultrasound led to diagnostic GIST. The endoscopic resection (Endoscopic Submucosal Excavation) was performed in the same surgical procedure for abdominal hernia repair. The surgery team contributed to strengthening the closure of the post-resection defect, although there was no free perforation. Endoscopic submucosal excavation (ESE) has been shown to be a safe and effective option in the endoscopic resection of GISTs.
GASTROINTESTINAL MANIFESTATIONS IN COVID-19: A PROSPECTIVE STUDY
Authors: T. Addajou, S. Rokhsi, S. Mrabti, A. Benhamdane, M.O. Guelleh, A. Touibi, A. Sair, R. Berrida, I. Elkoti, F. Rouibaa, A. Benkirane, H. Seddik
Journal: Endoscopy (2022)

Aims Gastrointestinal manifestations are common during coronavirus disease (COVID-19) infection. They can occur before respiratory symptoms, resulting in a diagnostic delay and an increased risk of disease transmission. The current study reports major gastrointestinal manifestations as initial symptoms of COVID-19.
EFFICACY OF A COMPUTER AIDED DETECTION (CADE) SYSTEM IN A FIT-BASED ORGANIZED COLORECTAL CANCER SCREENING PROGRAM: A RANDOMIZED CONTROLLED TRIAL
Authors: D. Di Paolo, E. Rondonotti, S. Paggi, E. Rosa Rizzotto, C. Alvisi, E. Buscarini, M. Spadaccini, G. Tamanini, A. Amato, G. Scardino, G. Mandelli, N. Lenoci, N. Terreni, S. Romeo, S. Alicante, F. Ancona, E. Guido, V. Marzo, F. Chicco, S. Agazzi, A. Repici, L. Ambrosini, E. Filippi, R. Sassatelli, G. Sereni, K. Khalaf, C. Hassan, F. Radaelli
Journal: Endoscopy (2022)

Aims Computer Aided Detection (CADe) increases adenoma detection in primary screening colonoscopy. The potential benefit of CADe in FIT-based screening programs, where the prevalence of neoplasia is high, has never been evaluated.
CONTRIBUTION OF MACRODILATATION OF THE ODDI SPHINCTER IN THE TREATMENT OF LARGE CHOLEDCOCIAL STONES
Authors: S. Mrabti, T. Addajou, A. Benhamdane, A. Sair, M.O. Guelleh, A. Touibi, I. Radouane, S. Rokhsi, H. Iloghmane, R. Laaroussi, S. Sentissi, R. Berrida, I. El Koti, F. Rouibaa, A. Benkirane, H. Seddik
Journal: Endoscopy (2022)

Aims The objective is to evaluate the effectiveness of sphincteroplasty and to analyze the factors associated with the success of this technique in patients with large bile duct stones.
COVID-19 vaccine effectiveness against severe disease from SARS-CoV-2 Omicron BA.1 and BA.2 subvariants – surveillance results from southern Sweden, December 2021 to March 2022
Authors: Jonas Björk, Carl Bonander, Mahnaz Moghaddassi, Magnus Rasmussen, Ulf Malmqvist, Malin Inghammar, Fredrik Kahn
Journal: Eurosurveillance (2022)

We compared vaccine effectiveness against severe COVID-19 between December 2021 and March 2022 when Omicron BA.1 and BA.2 were the dominating SARS-CoV-2 variants in Scania county, Sweden. Effectiveness remained above 80% after the transition from BA.1 to BA.2 among people with at least three vaccine doses but the point estimate decreased markedly to 54% among those with only two doses. Protection from prior infection was also lower after the transition to BA.2. Booster vaccination seems necessary to maintain sufficient protection.
LncRNA-PACERR induces pro-tumour macrophages via interacting with miR-671-3p and m6A-reader IGF2BP2 in pancreatic ductal adenocarcinoma
Authors: Yihao Liu, Minmin Shi, Xingfeng He, Yizhi Cao, Pengyi Liu, Fanlu Li, Siyi Zou, Chenlei Wen, Qian Zhan, Zhiwei Xu, Jiancheng Wang, Baofa Sun, Baiyong Shen
Journal: Journal of Hematology & Oncology (2022)

LncRNA-PACERR plays critical role in the polarization of tissue-associated macrophages (TAMs). In this study, we found the function and molecular mechanism of PACERR in TAMs to regulate pancreatic ductal adenocarcinoma (PDAC) progression.We used qPCR to analyse the expression of PACERR in TAMs and M1-tissue-resident macrophages (M1-NTRMs) which were isolated from 46 PDAC tissues. The function of PACERR on macrophages polarization and PDAC proliferation, migration and invasion were confirmed through in vivo and in vitro assays. The molecular mechanism of PACERR was discussed via fluorescence in situ hybridization (FISH), RNA pull-down, ChIP-qPCR, RIP-qPCR and luciferase assays.LncRNA-PACERR was high expression in TAMs and associated with poor prognosis in PDAC patients. Our finding validated that LncRNA-PACERR increased the number of M2-polarized cells and facilized cell proliferation, invasion and migration in vitro and in vivo. Mechanistically, LncRNA-PACERR activate KLF12/p-AKT/c-myc pathway by binding to miR-671-3p. And LncRNA-PACERR which bound to IGF2BP2 acts as an m6A-dependent manner to enhance the stability of KLF12 and c-myc in cytoplasm. In addition, the promoter of LncRNA-PACERR was a target of KLF12 and LncRNA-PACERR recruited EP300 to increase the acetylation of histone by interacting with KLF12 in nucleus.This study found that LncRNA-PACERR functions as key regulator of TAMs in PDAC microenvironment and revealed the novel mechanisms in cytoplasm and in nucleus.
Acute psychiatric care: approaches to increasing the range of services and improving access and quality of care
Authors: Sonia Johnson, Christian Dalton‐Locke, John Baker, Charlotte Hanlon, Tatiana Taylor Salisbury, Matt Fossey, Karen Newbigging, Sarah E. Carr, Jennifer Hensel, Giuseppe Carrà, Urs Hepp, Constanza Caneo, Justin J. Needle, Brynmor Lloyd‐Evans
Journal: World Psychiatry (2022)

Acute services for mental health crises are very important to service users and their supporters, and consume a substantial share of mental health resources in many countries. However, acute care is often unpopular and sometimes coercive, and the evidence on which models are best for patient experience and outcomes remains surprisingly limited, in part reflecting challenges in conducting studies with people in crisis. Evidence on best ap-proaches to initial assessment and immediate management is particularly lacking, but some innovative models involving extended assessment, brief interventions, and diversifying settings and strategies for providing support are potentially helpful. Acute wards continue to be central in the intensive treatment phase following a crisis, but new approaches need to be developed, evaluated and implemented to reducing coercion, addressing trauma, diversifying treatments and the inpatient workforce, and making decision-making and care collaborative. Intensive home treatment services, acute day units, and community crisis services have supporting evidence in diverting some service users from hospital admission: a greater understanding of how best to implement them in a wide range of contexts and what works best for which service users would be valuable. Approaches to crisis management in the voluntary sector are more flexible and informal: such services have potential to complement and provide valuable learning for statutory sector services, especially for groups who tend to be underserved or disengaged. Such approaches often involve staff with personal experience of mental health crises, who have important potential roles in improving quality of acute care across sectors. Large gaps exist in many low- and middle-income countries, fuelled by poor access to quality mental health care. Responses need to build on a foundation of existing community responses and contextually relevant evidence. The necessity of moving outside formal systems in low-resource settings may lead to wider learning from locally embedded strategies.
ENDOCYTOSCOPY-BASED IN VIVO GRADING OF INFLAMMATORY ACTIVITY IN ULCERATIVE CORRELATES WITH HISTOLOGY AND CAN PREDICT LONG-TERM DISEASE BEHAVIOUR
Authors: F. Vitali, N. Morgenstern, R. Atreya, M. Waldner, A. Hartmann, M.F. Neurath, T. Rath
Journal: Endoscopy (2022)

Aims Increasing evidence suggests that not only mucosal healing, but also histologic healing could be an essential prognostic parameter in patients with inflammatory bowel diseases (IBD). Within this study, we aimed to evaluate whether endocytoscopy as a new technique enabling in vivo histology can accurately assess histologic inflammation in IBD patients and predict long-term disease outcome.