tbuckley/cabot-search huggingface dataset:
Response to: ‘Correspondence on ‘Novel ultrasonographic Halo Score for giant cell arteritis: assessment of diagnostic accuracy and association with ocular ischaemia’’ by Evangelatos<i>et al</i>
Authors: Kornelis SM van der Geest, Bhaskar Dasgupta
Journal: Annals of the Rheumatic Diseases (2020)

We thank Evangelatos et al 1 for their interest in our study on the ultrasonographic Halo Score for giant cell arteritis (GCA).2 The evaluation of patients with suspected GCA can be challenging.3 Ultrasonography is an important diagnostic tool for GCA and allows to evaluate key arteries affected by the disease.4 Currently, it is recommended to perform ultrasonography of the temporal and axillary arteries in patients with suspected GCA.5 6 For this reason, the ultrasonographic Halo Score is based on measurements of these two arteries. Whether or not additional arteries should be evaluated remains a topic of debate.7 8

We welcome the effort of Evangelatos et al to evaluate the …
Regarding methodologic concerns in clinical studies on frontal fibrosing alopecia
Authors: Paulo Müller Ramos, Alessandra Anzai, Bruna Duque-Estrada, Debora Cadore Farias, Daniel Fernandes Melo, Fabiane Mulinari-Brenner, Giselle Martins Pinto, Leonardo Spagnol Abraham, Leopoldo Duailibe Nogueira Santos, Rodrigo Pirmez, Hélio Amante Miot
Journal: Journal of the American Academy of Dermatology (2020)
Synovial Fluid Neutrophils From Patients With Juvenile Idiopathic Arthritis Display a Hyperactivated Phenotype
Authors: Mieke Metzemaekers, Bert Malengier‐Devlies, Karen Yu, Sofie Vandendriessche, Jonas Yserbyt, Patrick Matthys, Lien De Somer, Carine Wouters, Paul Proost
Journal: Arthritis & Rheumatology (2020)

Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in childhood. The predominant subtypes, oligoarticular and polyarticular JIA, are traditionally considered to be autoimmune diseases with a central role for T cells and autoantibodies. Mounting evidence suggests an important role for neutrophils in JIA pathogenesis. We undertook this study to investigate the phenotypic features of neutrophils present in the blood and inflamed joints of patients.JIA synovial fluid (SF) and parallel blood samples from JIA patients and healthy children were collected. SF-treated neutrophils from healthy donors and pleural neutrophils from patients with pleural effusion were investigated as controls for SF exposure and extravasation. Multicolor flow cytometry panels allowed for in-depth phenotypic analysis of neutrophils, focusing on the expression of adhesion molecules, activation, and maturation markers and chemoattractant receptors. Multiplex technology was used to quantify cytokines in plasma and SF.SF neutrophils displayed an activated, hypersegmented phenotype with decreased CD62L expression, up-regulation of adhesion molecules CD66b, CD11b, and CD15, and down-regulation of CXCR1/2. An elevated percentage of CXCR4-positive neutrophils was detected in SF from patients. Pleural neutrophils showed less pronounced maturation differences. Strikingly, significant percentages of SF neutrophils showed a profound up-regulation of atypical neutrophil markers, including CXCR3, intercellular adhesion molecule 1, and HLA-DR.Our data show that neutrophils in inflamed joints of JIA patients have an activated phenotype. This detailed molecular analysis supports the notion that a complex intertwining between these innate immune cells and adaptive immune events drives JIA.
Abstract PO-046: Assessment of COVID-19 vaccine candidates: Prediction and validation of 174 SARS-CoV-2 epitopes
Authors: Marek Prachar, Sune Justesen, Daniel Bisgaard Steen-Jensen, Stephan Thorgrimsen, Erik Jurgons, Ole Winther, Frederik Otzen Bagger
Journal: Clinical Cancer Research (2020)

Abstract The recent outbreak of SARS-CoV-2 (2019-nCoV) virus has highlighted the need for fast and efficacious vaccine development. Stimulation of a proper immune response that leads to protection is highly dependent on presentation of epitopes to circulating T-cells via the HLA complex. SARS-CoV-2 is a large RNA virus and testing of all of its overlapping peptides in vitro to deconvolute an immune response is not feasible. Therefore, HLA-binding prediction tools are often used to narrow down the number of peptides to test. We tested 19 epitope-HLA-binding prediction tools, and using an in vitro peptide-MHC stability assay, we assessed 777 peptides that were predicted to be good binders across 11 MHC alleles. In this investigation of potential SARS-CoV-2 epitopes, we found that current prediction tools vary in performance when assessing binding stability, and they are highly dependent on the MHC allele in question. Designing a COVID-19 vaccine where only a few epitope targets are included is therefore a very challenging task. Here, we present 174 SARS-CoV-2 epitopes with high prediction binding scores, validated to bind stably to 11 HLA alleles. Our findings may contribute to the design of an efficacious vaccine against COVID-19. Citation Format: Marek Prachar, Sune Justesen, Daniel Bisgaard Steen-Jensen, Stephan Thorgrimsen, Erik Jurgons, Ole Winther, Frederik Otzen Bagger. Assessment of COVID-19 vaccine candidates: Prediction and validation of 174 SARS-CoV-2 epitopes [abstract]. In: Proceedings of the AACR Virtual Meeting: COVID-19 and Cancer; 2020 Jul 20-22. Philadelphia (PA): AACR; Clin Cancer Res 2020;26(18_Suppl):Abstract nr PO-046.
Percutaneous-endoscopic rendezvous via cap-assisted adult colonoscope to deal with biliary and multiple intestine strictures after total gastrectomy
Authors: Zhenghong Li, Weiming Dai, Lijuan Yang, Rong Wan, Xiaobo Cai
Journal: Endoscopy (2020)

A 68-year-old man was admitted with vomiting and jaundice. He had undergone total gastrectomy and Roux-en-Y jejunojejunostomy for cardiac cancer a year earlier. Magnetic resonance imaging indicated abdominal tumor metastasis and dilatation of the intrahepatic bile ducts.
The Anatomical Basis of Pulmonary Vein Reconnection After Ablation for Atrial Fibrillation: Wounds That Never Felt a Scar?⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Authors: Thomas J. McGarry, Sanjiv M. Narayan
Journal: Journal of the American College of Cardiology (2012)
Abstract 13202: Significance of Systolic Blood Pressure on the Progression of Coronary Atherosclerosis in Subjects With Low Cardiovascular Risk
Authors: Ki-Bum Won, Ran Heo, Byoung Kwon Lee, Sang-Eun Lee, Asim Rizvi, Fay Y Lin, Martin Hadamitzky, Yong-Jin Kim, Matthew J Budoff, Ilan Gottlieb, Eun Ju Chun, Filippo Cademartiri, Jonathon Leipsic, Sanghoon Shin, Jung Hyun Choi, Renu Virmani, Habib Samady, Kavitha M Chinnaiyan, Gilbert Raff, Peter H Stone, Daniel Berman, Jagat Narula, Leslee J Shaw, Jeroen J Bax, James K Min, Hyuk-Jae Chang
Journal: Circulation (2019)

Introduction: Despite recently reinforced guidelines for hypertension, little is known regarding the association between blood pressure and coronary plaque volume change (PVC) in individuals with l...
Blastic Plasmacytoid Dendritic-Cell Neoplasm
Authors: Yung Gonzaga, Mayne Fontes
Journal: New England Journal of Medicine (2020)

A 29-year-old man presented with progressive skin lesions on the face, back, trunk, and limbs. Biopsy was performed, and a diagnosis of blastic plasmacytoid dendritic-cell neoplasm was made.
270MO A single-arm, open-label, multicenter phase II study of camrelizumab in patients with recurrent or metastatic (R/M) nasopharyngeal carcinoma (NPC) who had progressed on ≥2 lines of chemotherapy: CAPTAIN study
Authors: L. Zhang, Y. Yang, X. Chen, J. Li, J. Pan, X. He, L. Lin, Y. Shi, W. Feng, J. Xiong, K. Yang, Q. Yu, D. Hu, Y. Sun, Q. Zhang, G. Hu, P. Li, L. Shen, Q. Yang, B. Zhang
Journal: Annals of Oncology (2020)
143P Lymph nodes metastasis is the most important factor associated with pattern of recurrence following curative resection of gastric adenocarcinoma
Authors: F-H. Wang, Z-K. Wang, Z. Xue, J-X. Lin, C-H. Zheng, P. Li, J-W. Xie, J-B. Wang, J. Lu, Q-Y. Chen, L-L. Cao, M. Lin, R-H. Tu, Z-N. Huang, J-L. Lin, H-L. Zheng, C. Huang
Journal: Annals of Oncology (2020)
Serial Cardiovascular Magnetic Resonance Strain Measurements to Identify Cardiotoxicity in Breast Cancer
Authors: Christian P. Houbois, Mark Nolan, Emily Somerset, Tamar Shalmon, Maryam Esmaeilzadeh, Mariana M. Lamacie, Eitan Amir, Christine Brezden-Masley, C. Anne Koch, Yobiga Thevakumaran, Andrew T. Yan, Thomas H. Marwick, Bernd J. Wintersperger, Paaladinesh Thavendiranathan
Journal: JACC. Cardiovascular imaging (2020)
Periodic screening of donor faeces with a quarantine period to prevent transmission of multidrug-resistant organisms during faecal microbiota transplantation: a retrospective cohort study
Authors: Karuna E W Vendrik, Elisabeth M Terveer, Ed J Kuijper, Sam Nooij, Eline Boeije-Koppenol, Ingrid M J G Sanders, Emilie van Lingen, Hein W Verspaget, Eric K L Berssenbrugge, Josbert J Keller, Joffrey van Prehn, Eduard J. Kuijper, Josbert J. Keller, Elisabeth M. Terveer, Joffrey van Prehn, Emilie van Lingen, Eline Boeije-Koppenol, Karuna E.W. Vendrik, Eric K.L. Berssenbrugge, Hein W. Verspaget, Martijn P. Bauer, Abraham Goorhuis, Els van Nood, Chris J.J. Mulder, Rogier Ooijevaar, Yvette van Beurden, Christina M.J.E. Vandenbroucke-Grauls
Journal: The Lancet Infectious Diseases (2020)
Abstract 10617: Evaluation of Treatment With Angiotensin Converting Enzyme Inhibitors (ACEIs) and the Risk of Lung Cancer (ERACER)
Authors: Jeffrey L Anderson, Kirk U Knowlton, Joseph B Muhlestein, Tami L Bair, Donald L Lappe, Viet T Le, Santanu Biswas, Benjamin D Horne
Journal: Circulation (2019)

Introduction: ACEIs are widely prescribed cardiovascular medications. A large British study* recently reported a 14% greater risk of lung cancer with ACEI than angiotensin receptor blocker (ARB) pr...
Abstract 12279: Direct Comparison of Resting Full-cycle Ratio With Fractional Flow Reserve in Physiological Assessment of Intermediate Coronary Artery Stenosis
Authors: Tomohiro Honda, Seiji Koga, Ryohei Akashi, Yuki Yamagata, Tsuyoshi Yonekura, Satoshi Ikeda, Hiroaki Kawano, Koji Maemura
Journal: Circulation (2019)

Introduction: Resting full-cycle ratio (RFR) is a novel hyperemia-free resting index of physiologic significance of coronary artery disease (CAD). Previous studies have reported that RFR is highly ...
Covid-19: Safety of lateral flow tests questioned after they are found to miss half of cases
Authors: Jacqui Wise
Journal: BMJ (2020)

Covid-19: Safety of lateral flow tests questioned after they are found to miss half of cases Jacqui WiseThe lateral flow devices used in the community testing pilot in Liverpool only picked up half the covid-19 cases detected by polymerase chain reaction (PCR) tests and missed three out of 10 cases with higher viral loads, according to the government's own policy paper. 1 Given the low sensitivity of the Innova lateral flow devices when used in the field, experts are questioning how they can be used to allow care home residents to have contact with relatives over Christmas safely or for students to know for certain that they are not infected before returning home.
Drug repurposing approach to combating coronavirus: Potential drugs and drug targets
Authors: Jimin Xu, Yu Xue, Richard Zhou, Pei‐Yong Shi, Hongmin Li, Jia Zhou
Journal: Medicinal Research Reviews (2020)

Abstract In the past two decades, three highly pathogenic human coronaviruses severe acute respiratory syndrome coronavirus (SARS‐CoV), Middle East respiratory syndrome coronavirus, and, recently, SARS‐CoV‐2, have caused pandemics of severe acute respiratory diseases with alarming morbidity and mortality. Due to the lack of specific anti‐CoV therapies, the ongoing pandemic of coronavirus disease 2019 (COVID‐19) poses a great challenge to clinical management and highlights an urgent need for effective interventions. Drug repurposing is a rapid and feasible strategy to identify effective drugs for combating this deadly infection. In this review, we summarize the therapeutic CoV targets, focus on the existing small molecule drugs that have the potential to be repurposed for existing and emerging CoV infections of the future, and discuss the clinical progress of developing small molecule drugs for COVID‐19.
Abstract 15147: Targeted Activation of Peroxisome Proliferator-Activated Receptor Gamma (PPARG) Rapidly Suppresses Inflammation Through Inhibition of Toll-Like Receptor 4/Nuclear Factor-kappa B (TLR4/NF-kappa B) Pathway and Further Shifts Advanced Atheroma Into a Stable Phenotype
Authors: Joon Woo Song, Hyeong Soo Nam, Hyun-Sang Park, Sunwon Kim, Hyun Jung Kim, Yeon Hoon Kim, Jae Won Ahn, Jah Yeon Choi, Dong Oh Kang, Seung-Yul Lee, Wang-Yuhl Oh, Hongki Yoo, Kyeongsoon Park, Jin Won Kim
Journal: Circulation (2019)

Introduction: Macrophages are major contributors of atherosclerotic plaque progression and destabilization. In our previous study, macrophage mannose receptor (MMR)-targeted delivery of PPARγ agoni...
Negative Conversion Rate of SARS-CoV-2 Infection
Authors: Ruiyuan Zhang, Huiying Liang, Jinling Tang
Journal: JAMA Internal Medicine (2020)

Seungjae Lee, MD; Tark Kim, MD; Eunjung Lee, MD; Cheolgu Lee, MD; Hojung Kim, MD; Heejeong Rhee, MD; Se Yoon Park, MD; Hyo-Ju Son, MD; Shinae Yu, MD; Jung Wan Park, MD; Eun Ju Choo, MD; Suyeon Park, MS; Mark Loeb, MD; Tae Hyong Kim, MD
Abstract 16400: Neuregulin-1 Promotes Cardiomyocyte Survival and Proliferation Under in vitro Conditions of Hypoxic Hyperglycemic Stress
Authors: Frederick Grady, Lyndsay M Stapleton, Amanda N Steele, Hanjay Wang, Anahita Eskandari, Camille E Hironaka, Akshara D Thakore, Kevin J Jaatinen, Kiah M Williams, Rachel Blair, Y. Joseph Woo
Journal: Circulation (2019)

Introduction: Neuregulin-1 (NRG) has potent mitotic and proliferative effects on cardiomyocytes (CM) but has not been studied in a more clinically-relevant hypoxic hyperglycemic environment modelin...
Quantitative <i>in Vitro</i> to <i>in Vivo</i> Extrapolation (QIVIVE) for Predicting Reduced Anogenital Distance Produced by Anti-Androgenic Pesticides in a Rodent Model for Male Reproductive Disorders
Authors: Martin Scholze, Camilla Taxvig, Andreas Kortenkamp, Julie Boberg, Sofie Christiansen, Terje Svingen, Karin Lauschke, Henrik Frandsen, Sibylle Ermler, Susan Strange Hermann, Mikael Pedersen, Anne Kruse Lykkeberg, Marta Axelstad, Anne Marie Vinggaard
Journal: Environmental Health Perspectives (2020)

Background: Many pesticides can antagonize the androgen receptor (AR) or inhibit androgen synthesis in vitro but their potential to cause reproductive toxicity related to disruption of androgen action during fetal life is difficult to predict. Currently no approaches for using in vitro data to anticipate such in vivo effects exist. Prioritization schemes that limit unnecessary in vivo testing are urgently needed. Objectives: The aim was to develop a quantitative in vitro to in vivo extrapolation (QIVIVE) approach for predicting in vivo anti-androgenicity arising from gestational exposures and manifesting as a shortened anogenital distance (AGD) in male rats. Methods: We built a physiologically based pharmacokinetic (PBK) model to simulate concentrations of chemicals in the fetus resulting from maternal dosing. The predicted fetal levels were compared with analytically determined concentrations, and these were judged against in vitro active concentrations for AR antagonism and androgen synthesis suppression. Results: We first evaluated our model by using in vitro and in vivo anti-androgenic data for procymidone, vinclozolin, and linuron. Our PBK model described the measured fetal concentrations of parent compounds and metabolites quite accurately (within a factor of five). We applied the model to nine current-use pesticides, all with in vitro evidence for anti-androgenicity but missing in vivo data. Seven pesticides (fludioxonil, cyprodinil, dimethomorph, imazalil, quinoxyfen, fenhexamid, o-phenylphenol) were predicted to produce a shortened AGD in male pups, whereas two (λ-cyhalothrin, pyrimethanil) were anticipated to be inactive. We tested these expectations for fludioxonil, cyprodinil, and dimethomorph and observed shortened AGD in male pups after gestational exposure. The measured fetal concentrations agreed well with PBK-modeled predictions. Discussion: Our QIVIVE model newly identified fludioxonil, cyprodinil, and dimethomorph as in vivo anti-androgens. With the examples investigated, our approach shows great promise for predicting in vivo anti-androgenicity (i.e., AGD shortening) for chemicals with in vitro activity and for minimizing unnecessary in vivo testing. https://doi.org/10.1289/EHP6774
16311 Protective effects of an active complex against unbalanced biomarkers induced by infrared-A radiation, blue light, and heavy metals: An integral approach of skin aging
Authors: Liliana Torloni, Lara Facó, Erida Magaton, Samara Eberlin, Ana Lúcia Alves Tabarini Pinheiro
Journal: Journal of the American Academy of Dermatology (2020)
Low Dose Donor Lymphocyte Infusion (DLI) Is Effective As Prophylactic Therapy for Mixed Chimerism in the Setting of In-Vivo T Cell Depleted Allogeneic Hematopoietic Cell Transplantation
Authors: Dinesh Atwal, Krishna Joshi, Anusha Jillela, Pooja Motwani, Appalanaidu Sasapu, Muthu Veeraputhiran
Journal: Blood (2017)
CD40-mediated immune cell activation enhances response to anti-PD-1 in murine intrahepatic cholangiocarcinoma
Authors: Laurence P. Diggs, Benjamin Ruf, Chi Ma, Bernd Heinrich, Linda Cui, Qianfei Zhang, John C. McVey, Simon Wabitsch, Sophia Heinrich, Umberto Rosato, Walter Lai, Varun Subramanyam, Thomas Longerich, Sven H. Loosen, Tom Luedde, Ulf Peter Neumann, Sabina Desar, David Kleiner, Gregory Gores, Xin Wei Wang, Tim F. Greten
Journal: Journal of Hepatology (2020)
16636 Use of direct immunofluorescence in the diagnosis of autoimmune and immunobullous diseases of the esophagus
Authors: Amber Jimenez, Benjamin Jones, Christopher Hull, Meganne Ferrel, Jamie Rhoads, Marjorie Allen, Kathryn Peterson, John Fang, Kristin Leiferman, John Zone
Journal: Journal of the American Academy of Dermatology (2020)
267O Distinct phenotypes of locoregionally advanced (LA-NPC) harbor disparate survival outcomes and are associated with germline variants
Authors: E. Ong, A.Y.L. Sim, L. Huang, K.P. Low, W. Wai Yee, D. Susanti, H. Wang, T.W.K. Tan, K.W. Fong, Y.L. Soong, G.S. Tan, T.K.H. Lim, J.T.S. Wee, D.W.T. Lim, N.G. Iyer, J.S.G. Hwang, M. Abazeed, J.X. Bei, M.L.K. Chua
Journal: Annals of Oncology (2020)
Top 10 research priorities for people living with pulmonary fibrosis, their caregivers, healthcare professionals and researchers
Authors: Gabriella Tikellis, Allison Tong, Joanna Y T Lee, Tamera J. Corte, Alison J Hey-Cunningham, Michael Bartlett, Tonia Crawford, Ian Glaspole, John Price, Jamie Maloney, Anne E Holland
Journal: Thorax (2020)

People with pulmonary fibrosis (PF) experience a high symptom burden, reduced quality of life and a shortened lifespan. Treatment options are limited and little is known about what patients, caregivers and healthcare professionals (HCPs)/researchers consider as the most important research priorities. This study aimed to identify the top 10 research priorities for PF across all stakeholders.Participants included people with PF, caregivers and HCPs/researchers involved with PF. The research priority setting exercise involved three stages: (1) identifying priorities using an open-ended questionnaire and thematic analysis, (2) development of specific research questions at a face-to-face workshop, and (3) online ranking of research questions to identify the top 10 research priorities using nominal group ranking method.196 participants completed stage 1 generating 560 questions and 14 research themes were identified. Stage 2 involved 32 participants and generated 53 indicative questions from which 39 were used for the final ranking. Stage 3 was completed by 270 participants. The top ranked priorities focussed on medications to reverse scarring in the lungs (ranked 1st), improving lung function (ranked 2nd, 6th and 8th), interventions aimed at alleviating symptoms (ranked 5th and 7th), prevention of PF (ranked 3rd and 4th) and the best exercise programme for PF (ranked 10th). There was good consensus among patients/carers and HCPs/researchers on the top 10 priorities, however, causes of acute exacerbations and early diagnosis for improving survival, was ranked higher by HCPs/researchers.Interventions for preserving lung health and alleviation of symptom burden were top research priorities for PF stakeholders.
Parameterizing neural power spectra into periodic and aperiodic components
Authors: Thomas Donoghue, Matar Haller, Erik J. Peterson, Paroma Varma, Priyadarshini Sebastian, Richard Gao, Torben Noto, Antonio H. Lara, Joni D. Wallis, Robert T. Knight, Avgusta Shestyuk, Bradley Voytek
Journal: Nature Neuroscience (2020)
Corrigendum to ‘quantitative determination of 64Cu-liposome accumulation at inflammatory and infectious sites: Potential for future theranostic system’: [journal of controlled release 327 (2020) 737–746]
Authors: Anne Skovsbo Clausen, Daniella Elisabet Østergaard, Petter Holmberg, Jonas Rosager Henriksen, Johan Tham, Peter Panduro Damborg, Andreas I. Jensen, Andreas Kjaer, Anders Elias Hansen, Thomas Lars Andresen
Journal: Journal of Controlled Release (2020)
7P Machine learning intratumoral and axillary lymph node magnetic resonance imaging radiomics for predicting axillary lymph node metastasis in patients with early-stage invasive breast cancer (RBC-01 Study)
Authors: Y. Tan, Y. Yu, J. Liu, Z. He, Y. Chen, W. Ren, A. Li, J. Ma, N. Lu, C. Li, X. Li, Q. Ou, Q. Hu, K. Chen, J. Ouyang, F. Su, C. Xie, E. Song, H. Yao
Journal: Annals of Oncology (2020)
8P Knowledge, practice and attitudes of physicians in low- and middle-income countries (LMIC) on fertility and pregnancy-related issues in young breast cancer patients
Authors: S. Zeb Khan, C. Villarreal Garza, B. Sirohi, N.F. Ponde, B.S. Habeeb, M. Brandão, H.A. Azim, A.R. Chowdhury, I.B. Spasojevic, I. Kovalenko, A. Odhiambo, F.U. Seid, A. Mutombo, F. Petracci, R. Vidra, S.C. Altuna Mujica, B. Gyawali, D. Trapani, M. Tagliamento, M. Lambertini
Journal: Annals of Oncology (2020)