tbuckley/cabot-search huggingface dataset:
Artificial M2 macrophages for disease-modifying osteoarthritis therapeutics
Authors: Yandong Ma, Haiyuan Yang, Xiaoqing Zong, Jinpei Wu, Xin Ji, Wen Liu, Pengfei Yuan, Xinjie Chen, Caiqi Yang, Xiaodi Li, Yuanfeng Chen, Wei Xue, Jian Dai
Journal: Biomaterials (2021)
A RARE ENTITY THAT SHOULD NOT BE FORGOTTEN! NONBACTERIAL THROMBOTIC ENDOCARDITIS (NBTE)
Authors: Ruben Montanez, Rakhee R Makhija, Rohan Desai, Kazue Okajima, Ahmed Ibrahim, Harsha Nagarajarao, Chandra Ojha, Haider Alkhateeb
Journal: Journal of the American College of Cardiology (2021)
HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron
Authors: Rashi Singhal, Sreedhar R. Mitta, Nupur K. Das, Samuel A. Kerk, Peter Sajjakulnukit, Sumeet Solanki, Anthony Andren, Roshan Kumar, Kenneth P. Olive, Ruma Banerjee, Costas A. Lyssiotis, Yatrik M. Shah
Journal: Journal of Clinical Investigation (2021)

Hypoxia is a hallmark of solid tumors that promotes cell growth, survival, and metastasis and confers resistance to chemo and radiotherapies. Hypoxic responses are largely mediated by the transcription factors hypoxia-inducible factor 1α (HIF-1α) and HIF-2α. Our work demonstrates that HIF-2α is essential for colorectal cancer (CRC) progression. However, targeting hypoxic cells is difficult, and tumors rapidly acquire resistance to inhibitors of HIF-2α. To overcome this limitation, we performed a small molecule screen to identify HIF-2α-dependent vulnerabilities. Several known ferroptosis activators and dimethyl fumarate (DMF), a cell-permeable mitochondrial metabolite derivative, led to selective synthetic lethality in HIF-2α-expressing tumor enteroids. Our work demonstrated that HIF-2α integrated 2 independent forms of cell death via regulation of cellular iron and oxidation. First, activation of HIF-2α upregulated lipid and iron regulatory genes in CRC cells and colon tumors in mice and led to a ferroptosis-susceptible cell state. Second, via an iron-dependent, lipid peroxidation-independent pathway, HIF-2α activation potentiated ROS via irreversible cysteine oxidation and enhanced cell death. Inhibition or knockdown of HIF-2α decreased ROS and resistance to oxidative cell death in vitro and in vivo. Our results demonstrated a mechanistic vulnerability in cancer cells that were dependent on HIF-2α that can be leveraged for CRC treatment.
CLINICAL OUTCOMES IN ACUTE RIGHT VENTRICULAR FAILURE WITH PERCUTANEOUS RIGHT VENTRICULAR ASSIST DEVICES: IMPELLA RP AND PROTEK DUO
Authors: Nikhil Agrawal, Fariha Hameed, Lucas Battel, Ayush Arora, Sachin Kumar, Bindu Akkanti, Anju Bhardwaj, Rahat Hussain, Marwan Jumean, Sriram Nathan, Igor Gregoric, Biswajit Kar
Journal: Journal of the American College of Cardiology (2021)
A RARE CASE OF LARGE DIFFUSE BILATERAL RIGHT AND LEFT CORONARY ARTERY FISTULAS TERMINATING IN THE LEFT VENTRICLE
Authors: Iyad Farouji, Omar Alradaideh, Hossam Abed, Zaid Amin, Dilesha Kumanayaka, Joaquim Correia, Addi Suleiman
Journal: Journal of the American College of Cardiology (2021)
CAN ASSESSMENT OF MYOCARDIAL PERFUSION RESERVE DIFFERENTIATE BETWEEN ISCHEMIC AND NON ISCHEMIC CARDIOMYOPATHY WITH REDUCED EJECTION FRACTION
Authors: Shuo Wang, Hena Patel, Tamari Miller, Keith Ameyaw, Akhil Narang, Keigo Kawaji, Victor Mor-Avi, Amit R Patel
Journal: Journal of the American College of Cardiology (2021)
IN-HOSPITAL OUTCOMES OF ENDOVASCULAR INTERVENTION VS SURGICAL BYPASS IN PERIPHERAL VASCULAR DISEASE WITH CHRONIC TOTAL OCCLUSION
Authors: Mohamed Zghouzi, Homam Moussa Pacha, Waqas Ullah, Yasar Sattar, Bachar Ahmad, Abdul-Rahman Suleiman, Yasser Al-Khadra, Noora Alhajri, Tanveer Mir, Fahed Darmoch, Omar Ali, Delair Gardi, Zaher Hakim, M. Chadi Alraies
Journal: Journal of the American College of Cardiology (2021)
Methods for handling missing segments in Crohn’s disease clinical trials: analysis from the EXTEND trial
Authors: Christopher Ma, Reena Khanna, Leonardo Guizzetti, Guangyong Zou, Brian G Feagan, Vipul Jairath
Journal: Gut (2021)

Recently in Gut , Gottlieb et al summarised considerations for endoscopy central reading in IBD clinical trials.1 Achieving endoscopic remission is an important measure of therapeutic efficacy, and most Crohn’s disease (CD) trials now require video-recorded ileocolonoscopy at screening and for evaluation of the primary outcome. While the Crohn’s Disease Endoscopic Index of Severity (CDEIS)2 and the Simplified Endoscopic Score for Crohn’s Disease (SES-CD)3 are commonly used instruments, Gottlieb et al correctly highlight that these scores are sensitive to missing data if one or more of the five ileocolonic segments are not examined. Bowel segments may not be visualised if there is an impassable stricture, when the bowel preparation is poor or if there are technical challenges precluding procedure completion. In these situations, appropriately handling missing data is essential because the total endoscopic score may not be reflective of the actual disease burden. We empirically evaluated the effect of different methods for handling missing data from non-visualised segments on the SES-CD and CDEIS.

Ileocolonoscopy videos from baseline and week 12 in the Extend the Safety and Efficacy of Adalimumab through Endoscopic Healing (EXTEND) trial were used.4 EXTEND was a randomised, placebo-controlled trial evaluating adalimumab in patients with moderate-to-severe CD. Six methods of handling missing segments were applied:

1.  No imputation: non-visualised segments ignored.

2.  Worst …
Lifespan Perspective on Congenital Heart Disease Research
Authors: Gerhard-Paul Diller, Alexandra Arvanitaki, Alexander R. Opotowsky, Kathy Jenkins, Philip Moons, Alexander Kempny, Animesh Tandon, Andrew Redington, Paul Khairy, Seema Mital, Michael Α. Gatzoulis, Yue Li, Ariane Marelli
Journal: Journal of the American College of Cardiology (2021)
Elephant Genomes Reveal Accelerated Evolution in Mechanisms Underlying Disease Defenses
Authors: Marc Tollis, Elliott Ferris, Michael S Campbell, Valerie K Harris, Shawn M Rupp, Tara M Harrison, Wendy K Kiso, Dennis L Schmitt, Michael M Garner, Christina Athena Aktipis, Carlo C Maley, Amy M Boddy, Mark Yandell, Christopher Gregg, Joshua D Schiffman, Lisa M Abegglen
Journal: Molecular Biology and Evolution (2021)

Disease susceptibility and resistance are important factors for the conservation of endangered species, including elephants. We analyzed pathology data from 26 zoos and report that Asian elephants have increased neoplasia and malignancy prevalence compared with African bush elephants. This is consistent with observed higher susceptibility to tuberculosis and elephant endotheliotropic herpesvirus (EEHV) in Asian elephants. To investigate genetic mechanisms underlying disease resistance, including differential responses between species, among other elephant traits, we sequenced multiple elephant genomes. We report a draft assembly for an Asian elephant, and defined 862 and 1,017 conserved potential regulatory elements in Asian and African bush elephants, respectively. In the genomes of both elephant species, conserved elements were significantly enriched with genes differentially expressed between the species. In Asian elephants, these putative regulatory regions were involved in immunity pathways including tumor-necrosis factor, which plays an important role in EEHV response. Genomic sequences of African bush, forest, and Asian elephant genomes revealed extensive sequence conservation at TP53 retrogene loci across three species, which may be related to TP53 functionality in elephant cancer resistance. Positive selection scans revealed outlier genes related to additional elephant traits. Our study suggests that gene regulation plays an important role in the differential inflammatory response of Asian and African elephants, leading to increased infectious disease and cancer susceptibility in Asian elephants. These genomic discoveries can inform future functional and translational studies aimed at identifying effective treatment approaches for ill elephants, which may improve conservation.
A systematic review and meta-analysis on the association between ICSI and chromosome abnormalities
Authors: Sine Berntsen, Hannele Laivuori, Nina la Cour Freiesleben, Anne Loft, Viveca Söderström-Anttila, Nan B Oldereid, Liv Bente Romundstad, Åsa Magnusson, Max Petzold, Christina Bergh, Anja Pinborg
Journal: Human Reproduction Update (2021)

In the decade following the introduction of ICSI, a higher prevalence of de novo chromosome abnormalities, in particular sex chromosome and autosomal structural abnormalities, as well as inherited abnormalities was described in children conceived by ICSI compared to both naturally conceived (NC) children and children conceived by standard IVF. The explanation for the observed increase in prevalence is not clear and has been suggested to reflect parental factors (e.g. age or sperm quality) or to be a result of the ICSI procedure itself. Over the years, the procedure, as well as the patient group, and indications for ICSI treatment have changed.The objective of this systematic review and meta-analysis was to assess the prevalence of chromosome abnormalities in ICSI pregnancies and children and to examine any potentially increased risk compared to standard IVF and NC.Pubmed, Embase, Cochrane Libraries and Web of Science up to October 2020 were searched. Primary outcome measures were overall chromosome abnormalities and de novo abnormalities (including sex chromosome abnormalities and autosomal abnormalities). The secondary outcome was inherited abnormalities. We followed the PRISMA guidelines and relevant meta-analyses were performed.The search included 4648 articles, out of which 27 met the inclusion criteria, and 19 were included in quantitative synthesis (meta-analyses). The prevalence of chromosome abnormalities varied considerably between studies, possibly explained by large differences in sample size and patient demographics. Only five studies were eligible for pooled analyses on adjusted data. All studies had a critical risk of bias. Results from pooled adjusted data showed no evidence of an increased risk of overall chromosome abnormalities when comparing ICSI to either standard IVF (aOR 0.75 (95% CI 0.41-1.38)) or NC (aOR 1.29 (95% CI 0.69-2.43)). In contrast, meta-analyses on unadjusted data showed an increased risk of overall chromosome abnormalities in ICSI compared to both standard IVF (OR 1.42 (95% CI 1.09-1.85)) and NC (OR 2.46 (95% CI 1.52-3.99)) and an increased risk of de novo abnormalities in ICSI compared to NC (OR 2.62 (95% CI 2.07-3.31)). Yet, based on a very low certainty of evidence, the conclusion remains, that no indication of an increased risk of chromosome abnormalities in ICSI offspring could be found. If an increased risk of chromosome abnormalities in selected ICSI offspring should exist, the absolute risk continues to be small.This review provides an extensive overview of the existing evidence on the relationship between ICSI and chromosome abnormalities in the offspring. We highlight the need for well-designed large, prospective, controlled studies with systematic cytogenetic testing. Existing data are limited and, in many cases, marred by critical levels of bias.
Bortezomib Induces Anti–Multiple Myeloma Immune Response Mediated by cGAS/STING Pathway Activation
Authors: Annamaria Gulla, Eugenio Morelli, Mehmet K. Samur, Cirino Botta, Teru Hideshima, Giada Bianchi, Mariateresa Fulciniti, Stefano Malvestiti, Rao H. Prabhala, Srikanth Talluri, Kenneth Wen, Yu-Tzu Tai, Paul G. Richardson, Dharminder Chauhan, Tomasz Sewastianik, Ruben D. Carrasco, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Blood Cancer Discovery (2021)

Abstract The proteasome inhibitor bortezomib induces apoptosis in multiple myeloma cells and has transformed patient outcome. Using in vitro as well as in vivo immunodeficient and immunocompetent murine multiple myeloma models, we here show that bortezomib also triggers immunogenic cell death (ICD), characterized by exposure of calreticulin on dying multiple myeloma cells, phagocytosis of tumor cells by dendritic cells, and induction of multiple myeloma–specific immunity. We identify a bortezomib-triggered specific ICD gene signature associated with better outcome in two independent cohorts of patients with multiple myeloma. Importantly, bortezomib stimulates multiple myeloma cell immunogenicity via activation of the cGAS/STING pathway and production of type I IFNs, and STING agonists significantly potentiate bortezomib-induced ICD. Our study therefore delineates mechanisms whereby bortezomib exerts immunotherapeutic activity and provides the framework for clinical trials of STING agonists with bortezomib to induce potent tumor-specific immunity and improve patient outcome in multiple myeloma. Significance: Our study demonstrates that cGAS/STING-dependent immunostimulatory activity mediates bortezomib anti-myeloma activity in experimental models and associates with clinical response to bortezomib in patients with multiple myeloma. These findings provide the rationale for clinical evaluation of STING agonists to further potentiate anti–multiple myeloma immune response. See related commentary by Zitvogel and Kroemer, p. 405. This article is highlighted in the In This Issue feature, p. 403
The Kidney-Related Effects of Polystyrene Microplastics on Human Kidney Proximal Tubular Epithelial Cells HK-2 and Male C57BL/6 Mice
Authors: Yung-Li Wang, Yu-Hsuan Lee, Yung-Ho Hsu, I-Jen Chiu, Cathy Chia-Yu Huang, Chih-Chia Huang, Zi-Chun Chia, Chung-Pei Lee, Yuh-Feng Lin, Hui-Wen Chiu
Journal: Environmental Health Perspectives (2021)

Background: Understanding the epidemic of chronic kidney disease of uncertain etiology may be critical for health policies and public health responses. Recent studies have shown that microplastics (MPs) contaminate our food chain and accumulate in the gut, liver, kidney, muscle, and so on. Humans manufacture many plastics-related products. Previous studies have indicated that particles of these products have several effects on the gut and liver. Polystyrene (PS)-MPs (PS-MPs) induce several responses, such as oxidative stress, and affect living organisms. Objectives: The aim of this study was to investigate the effects of PS-MPs in kidney cells in vitro and in vivo. Methods: PS-MPs were evaluated in human kidney proximal tubular epithelial cells (HK-2 cells) and male C57BL/6 mice. Mitochondrial reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, inflammation, and autophagy were analyzed in kidney cells. In vivo, we evaluated biomarkers of kidney function, kidney ultrastructure, muscle mass, and grip strength, and urine protein levels, as well as the accumulation of PS-MPs in the kidney tissue. Results: Uptake of PS-MPs at different concentrations by HK-2 cells resulted in higher levels of mitochondrial ROS and the mitochondrial protein Bad. Cells exposed to PS-MPs had higher ER stress and markers of inflammation. MitoTEMPO, which is a mitochondrial ROS antioxidant, mitigated the higher levels of mitochondrial ROS, Bad, ER stress, and specific autophagy-related proteins seen with PS-MP exposure. Furthermore, cells exposed to PS-MPs had higher protein levels of LC3 and Beclin 1. PS-MPs also had changes in phosphorylation of mitogen-activated protein kinase (MAPK) and protein kinase B (AKT)/mitogen-activated protein kinase (mTOR) signaling pathways. In an in vivo study, PS-MPs accumulated and the treated mice had more histopathological lesions in the kidneys and higher levels of ER stress, inflammatory markers, and autophagy-related proteins in the kidneys after PS-MPs treatment by oral gavage. Conclusions: The results suggest that PS-MPs caused mitochondrial dysfunction, ER stress, inflammation, and autophagy in kidney cells and accumulated in HK-2 cells and in the kidneys of mice. These results suggest that long-term PS-MPs exposure may be a risk factor for kidney health. https://doi.org/10.1289/EHP7612
Long noncoding RNA MIR4435-2HG enhances metabolic function of myeloid dendritic cells from HIV-1 elite controllers
Authors: Ciputra Adijaya Hartana, Yelizaveta Rassadkina, Ce Gao, Enrique Martin-Gayo, Bruce D. Walker, Mathias Lichterfeld, Xu G. Yu
Journal: Journal of Clinical Investigation (2021)

Restriction of HIV-1 replication in elite controllers (ECs) is frequently attributed to T cell-mediated immune responses, while the specific contribution of innate immune cells is less clear. Here, we demonstrate an upregulation of the host long noncoding RNA (lncRNA) MIR4435-2HG in primary myeloid dendritic cells (mDCs) from ECs. Elevated expression of this lncRNA in mDCs was associated with a distinct immunometabolic profile, characterized by increased oxidative phosphorylation and glycolysis activities in response to TLR3 stimulation. Using functional assays, we show that MIR4435-2HG directly influenced the metabolic state of mDCs, likely through epigenetic mechanisms involving H3K27ac enrichment at an intronic enhancer in the RPTOR gene locus, the main component of the mammalian target of rapamycin complex 1 (mTORC1). Together, these results suggest a role of MIR4435-2HG for enhancing immunometabolic activities of mDCs in ECs through targeted epigenetic modifications of a member of the mTOR signaling pathway.
Abstract 12751: Relation of Red Blood Cell Distribution Width to Risk of Major Adverse Cardiovascular Events, Death, and Effect of Alirocumab After Acute Coronary Syndrome
Authors: Patrick M Moriarty, Philippe G Steg, Lauryn K Gorby, Andreas M Zeiher, Harvey D White, Timothee Sourdille, Matthew T Roe, Michael J Louie, J Wouter Jukema, Robert A Harrington, Shaun G Goodman, Rafael Diaz, Vera A Bittner, Deepak L Bhatt, Michael Szarek, Helen Li, Gregory G Schwartz
Journal: Circulation (2019)

Introduction: Red blood cell distribution width (RDW) reflects the dispersion of red blood cell (rbc) size and is a marker of inflammation, and when elevated is associated with risk for major adver...
Prevalence and Resolution of Resistant Left Atrial Appendage Thrombus in Non-Valvular Atrial Fibrillation Patients Submitted to Percutaneous Interventions
Authors: Fabricio Vassallo
Journal: Clinical Cardiology and Cardiovascular Interventions (2021)

Introduction: Left atrial appendage (LAA) thrombus in atrial tachyarrhythmias is one of the principal causes of stroke. Prevalence and strategies to thrombus resolution has recently been described in the era of the direct oral anticoagulants (DOAC). The aim of the study was to determine the prevalence and strategies to resolve previous LAA thrombus during regular oral antithrombotic therapy in preparation to perform atrial fibrillation (AF) ablation and/or LAA closure. Methods: Between January 2011 and December 2020 we prospectively followed 23 patients (5.39%) that showed LAA thrombus formation. Persistent AF occurred in 13 (56.52%), median age 72.39 years, 15 (65.22%) females, median CHA2DS2VASC of 4.13, HASBLED of 2.28, 17 (73.91%) with hypertension, (52.17%) with coronary disease, 9 (39.13%) had priors’ thromboembolic events, 7 (30.43%) with heart failure and Diabetes. Diagnosis was by transesophageal echocardiogram (TEE) in 20 (86.96%) and the rest by computed angiotomography. Rivaroxaban was used in 11 (47.83%), Dabigatran in 6 (26.09%), 5 (21.74%) with therapeutic range Warfarin and 1 (4.34%) with Apixaban. Main strategy of treatment was to change mechanism of action of antithrombotic medication in association to an antiplatelet drug, Clopidogrel 75mg a day, and perform a TEE at 90 days after. Results: Complete resolution of the LAA thrombus was achieved in 18 (78.26%) patients in first medical therapeutic change. Of the remaining a second approach with medical therapy adjustment with off-label dose prescription associated with Clopidogrel showed complete resolution in 3 (13.04%) totalizing a success rate of 91.30% for all patients (p value of 0.001 for treatment success). The failure of the antithrombotic plus antiplatelet therapy occurred in 2 (8.7%) patients, one with LAA sludge and other with a huge thrombus in all LAA and part of left atrium. Conclusion: Modification of the mechanism of action of direct oral anticoagulants in association with Clopidogrel demonstrates to be successful in a large number of patients with previous resistant left atrial thrombus with and secure since the low adverse event rates.
Reply to Alexa R. Meyer, Steven P. Rowe, and Nirmish Singla’s Letter to the Editor re: Patrick D. McGillivray, Daiki Ueno, Aydin Pooli, et al. Distinguishing Benign Renal Tumors with an Oncocytic Gene Expression (ONEX) Classifier. Eur Urol 2021;79:107–11. Integrating 99mTc-sestamibi and ONEX to Optimize Risk Stratification for Renal Masses
Authors: Brian Shuch, Steven Raman, Jeremie Calais
Journal: European Urology (2021)
Polylysine-decorated macroporous microcarriers laden with adipose-derived stem cells promote nerve regeneration in vivo
Authors: Yi Sun, Xiaoqi Chi, Haoye Meng, Mengjiao Ma, Jing Wang, Zhaoxuan Feng, Qi Quan, Guodong Liu, Yansen Wang, Yajie Xie, Yudong Zheng, Jiang Peng
Journal: Bioactive Materials (2021)

Cell transplantation is an effective strategy to improve the repair effect of nerve guide conduits (NGCs). However, problems such as low loading efficiency and cell anoikis undermine the outcomes. Microcarriers are efficient 3D cell culture scaffolds, which can also prevent cell anoikis by providing substrate for adhesion during transplantation. Here, we demonstrate for the first time microcarrier-based cell transplantation in peripheral nerve repair. We first prepared macroporous chitosan microcarriers (CSMCs) by the emulsion-phase separation method, and then decorated the CSMCs with polylysine (pl-CSMCs) to improve cell affinity. We then loaded the pl-CSMCs with adipose-derived stem cells (ADSCs) and injected them into electrospun polycaprolactone/chitosan NGCs to repair rat sciatic nerve defects. The ADSCs-laden pl-CSMCs effectively improved nerve regeneration as demonstrated by evaluation of histology, motor function recovery, electrophysiology, and gastrocnemius recovery. With efficient cell transplantation, convenient operation, and the multiple merits of ADSCs, the ADSCs-laden pl-CSMCs hold good potential in peripheral nerve repair.
LONG-TERM OUTCOMES AFTER SINGLE VERSUS DOUBLE STENTING FOR UNPROTECTED LEFT MAIN CORONARY ARTERY BIFURCATION LESIONS: AN UPDATED META-ANALYSIS
Authors: Raahat Bansal, Abhishek Thandra, Rosa Cruz Torres, Toufik Haddad, Venkata Alla
Journal: Journal of the American College of Cardiology (2021)
LEFT VENTRICULAR GLOBAL LONGITUDINAL STRAIN IN PATIENTS WITH PREVIOUS NON-HOSPITALIZED MILD TO MODERATE COVID-19, AND PRESERVED LEFT VENTRICULAR EJECTION FRACTION
Authors: Ercole Tagliamonte, Caterina Montuori, Lucia Riegler, Alberto Forni, Raffaella Scarafile, Alessandro Di Vilio, Simona Sperlongano, Juri Radmilovic, Roberta Astarita, Franco Iodice, Antonello D’Andrea
Journal: Journal of the American College of Cardiology (2021)
High-risk Human Papillomavirus Testing for Cervical Cancer Screening—Reply
Authors: Le Dang, Youlin Qiao, Jinghe Lang
Journal: JAMA Oncology (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal