tbuckley/cabot-search huggingface dataset:
FNA of palpable supraclavicular lymph nodes in lung cancer: Comparison between palpation and ultrasound
Authors: Dionisios Spyratos, Diamantis Chloros, Ariadni Mandrali, George Spyropoulos, Chrisoula Gioka, Lazaros Sichletidis
Journal: European Respiratory Journal (2011)

Introduction:  Clinical evaluation of the supraclavicular region is important for patients with suspected lung cancer as it is estimated that 26-42% of them had metastases to supraclavicular lymph nodes at diagnosis. Fine needle aspiration (FNA) cytology provides an easy method of obtaining both a diagnosis and staging.   Aim:  To compare the accuracy of FNA of palpable supraclavicular lymph nodes using palpation and ultrasound (US) among patients with suspected lung cancer.   Methods:  Over a 30 month period (6/2008 – 12/2010) we examined 71 consecutive patients (54 males, 64.3±11.5 years) suspected for lung cancer with palpable supraclavicular lymph nodes. All patients underwent US and palpation guided FNA at the same time. Samples were studied by immunohistochemical tests.   Results:  Sixty-four out of 71 patients had positive cytology by US (sensitivity: 93%) while the sensitivity of palpation was 90% (62/69). Seven patients underwent surgical sampling of lymph nodes and the diagnoses were: 3 patients with adenocarcinoma, 2 with small cell lung cancer (SCLC) and 2 M. tuberculosis. Cytological diagnoses by FNA were: SCLC (23 patients), adenocarcinoma (22), squamous (7), undifferentiated non-small cell lung cancer [NSCLC] (6), unknown origin (2), lymphoma (2), sarcoma (1), and large cell lung cancer (1). Among patients with NSCLC TNM classification was: stage IIIb (24) and IV (12). Patients with SCLC demonstrated: limited (16) and extensive disease (7). No adverse event was observed with both methods.   Conclusion:  FNA of palpable supraclavicular lymph nodes using clinical examination among patients with suspected lung cancer is a safe, cost-effective and as accurate as US guided method.
Abstract 10687: A Focused Heart Failure Self-Care Intervention Reduces Cardiac Deaths in Rural Patients
Authors: Kathleen Dracup, Debra Moser, Michele Pelter, Thomas Nesbitt, Jeffrey Southard, Steven M Paul, Martha J Biddle, Susan Robinson, Denise Loranger, Lawton S Cooper
Journal: Circulation (2012)

Background: Patients with heart failure (HF) who live in rural areas have less access to interdisciplinary HF programs than patients in urban areas and therefore require high levels of self-care. O...
The Low Back Pain Handbook: A Practical Guide for the Primary Care Clinician
Authors: Andrew J. Cole, Stanley A. Herring
Journal: Annals of Internal Medicine (1997)

Low back problems affect virtually everyone at some time. This book is an indispensable guide by experts in the field on the evaluation and practical management of low back pain. The information is present in accessible outline format, with key concepts in boldface type and clinical pearls featured at the beginning of each chapter for the busy family practitioner, internist, osteopath, physical therapist, resident, or fellow. Intended to be practical and useful, this text gives practitioners clear advice on diagnostics, clinical presentation, and therapeutic interventions of all kinds. Workers compensation, chronic pain programs, disability evaluations, impairment ratings, and legal issues are also thoroughly addressed.
Effects of ECT on brain structure: a pilot prospective magnetic resonance imaging study
Authors: C E Coffey, G S Figiel, W T Djang, D C Sullivan, R J Herfkens, R D Weiner
Journal: American Journal of Psychiatry (1988)

The authors describe a pilot prospective investigation of the effects of ECT on brain structure using magnetic resonance imaging (MRI). In nine patients with major depression, a course of ECT produced no acute changes in brain structure according to blind raters' assessments of cortical atrophy and global comparison of pre- and post-ECT studies. There were also no significant changes in the ventricle-brain ratios. Pre-ECT brain abnormalities were common in these patients yet were also unaffected by ECT. Future MRI studies of ECT should include more subjects and should address long-term changes and subtle brain abnormalities.
Abstract 5023: Gender Difference in In-hospital Mortality Following Coronary Angioplasty: Is it True Only in an Emergency Context ?
Authors: Jérôme Roncalli, Nicolas Boudou, Nicolas Dumonteil, Thibault Lhermusier, Olivier Lairez, Cécile Baixas, Meyer Elbaz, Jean-Bernard Ruidavets, Michel Galinier, Didier Carrié
Journal: Circulation (2008)

The aim of this study is to assess whether the excess risk of in-hospital mortality in women is noticed only when percutaneous coronary intervention (PCI) is performed in emergency after St+ acute coronary syndrome (ACS) or whether the excess risk is also observed after non-St+ ACS or unstable angina. During 3 years (2005–2007), 7847 consecutive PCI were performed in the University Department of Cardiology. The number of PCI performed in emergency for St+ ACS was 1529. The main end-point was in-hospital death and secondary outcomes included during the first 48 hours: stroke, emergency CABG surgery, recurrent myocardial infarction, new PCI and renal or vascular adverse events. The association between gender and in-hospital outcomes was assessed using multivariate logistic regression analysis. The proportion of women was 22.2% (n=340:1529) when angioplasty (in emergency) was performed in St+ ACS. History of renal failure was more prevalent in women (17.6% vs. 9.7%, p=0.001) whereas history of ischemic heart disease (previous myocardial infarction, coronary angioplasty or CABG surgery) was not significantly higher in men (24.1% vs. 20.9%). The percentage of deaths was 5.3% in women and 1.7% in men (p=0.001). The risk (OR [95% CI]) of in-hospital mortality for women vs. men (crude analysis) was 3.26 ([1.70 – 6.23], p=0.001) and 2.31 ([1.14 – 4.69], p=0.02) after multivariate adjustment for age, ischemic heart disease, year of procedure, renal failure, number of vessel disease, number of treated coronary arteries and thrombolytic therapy. The proportions of deaths were identical (0.64% and 0.60% in women and men respectively) when PCI was performed in a non-emergency setting in non-St+ ACS or unstable angina. The risk was similar before and after multivariate adjustment; 1.06 ([0.50 –2.26], p=0.87) and 0.91 ([0.42–1.98], p=0.81) respectively. The higher risk of in-hospital mortality for women is noticed only when PCI is performed in an emergency setting after St+ ACS. In non-urgent procedures the risk of death is similar to the one observed in men.
The Edwin Smith Surgical Papyrus: Published in Facsimile and Hieroglyphic Transliteration with Translation and Commentary in Two Volumes.
Authors: James Henry Breasted
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Selective Expansion of Regulatory T-Cells during Lenalidomid Treatment of MDS with Isolated Deletion 5q
Authors: Martin Wermke, Claudia Schuster, Claudia Schönefeldt, Sebastian Tuve, Gerhard Ehninger, Detlef Haase, Ulrich Germing, Martin Bornhäuser, Uta Oelschlaegel, Malte von Bonin, Uwe Platzbecker
Journal: Blood (2014)
Abstract 14611: Defibrillation Threshold Varies Over the Duration of Ventricular Fibrillation in Canine Hearts
Authors: Qi Jin, Ning Zhang, Yang Pang, Changjian Lin, Jian Zhou, Gang Gu, Weifeng Shen, Liqun Wu
Journal: Circulation (2011)

Introduction:  Recent studies have shown that short duration ventricular fibrillation (SDVF) and long duration ventricular fibrillation (LDVF) are maintained by different mechanisms. But little research has been performed to evaluate how the defibrillation threshold (DFT) alters over the duration of fibrillation.   Methods:  Two 64 electrodes basket catheters used to global endocardium electrical mapping were deployed into the LV and RV respectively. Internal defibrillation with biphasic shock was performed in 10 canines which were randomly divided into 2 groups (Group A, n=5, and Group B,n=5). DFTs of SDVF were measured with the shock given 20 s after VF induction in both groups. DFTs of LDVF were determined 1-3 min (Group A) and 5-7 min (Group B) respectively after VF induction.   Results:  Between 3 and 7 min of LDVF in Group B, endocardial activations became more highly organized than that within 1 to 3 min of LDVF in Group A. LDVF-DFT in Group A was significantly higher than LDVF-DFT in Group B. (670±60 vs 304±66 V, p   Conclusions:  After 3 min, VF can exhibit highly organized activation patterns, which might contribute to the decreased LDVF-DFT. The results of this study indicate that DFT may be affected differently as VF progresses.
Abstract 1238: Myofilament Calcium Sensitization Creates Arrhythmia Susceptibility in Familial Hypertrophic Cardiomyopathy
Authors: Franz Baudenbacher, Veniamin Y Sidorov, Tilmann Schober, Nagesh Chopra, Raghav Venkataraman, R J Solaro, James D Potter, Bjorn C Knollmann
Journal: Circulation (2007)

Although sudden cardiac death is a common feature in hypertrophic cardiomyopathy (HCM), the underlying mechanisms are unclear. We recently reported that some but not all mice expressing troponin mutations associated with HCM display increased myofilament calcium sensitivity. Here, we used these mice as well as acute challenge with the Ca 2+ sensitizing agent EMD57033 (EMD) in isolated mouse and rabbit hearts to test the hypothesis that myofilament sensitization leads directly to arrhythmia susceptibility. HCM mice with Ca 2+ sensitizing troponin mutations displayed significantly higher rate of ventricular ectopy (TnT-I79N 10±3, TnT-F110I 11±5, ssTnI 15±4 PVC/h) than mice expressing non-sensitizing troponins (TnT-R278C 1±1, TnT-WT 1±1, non-Tg 2±1 PVC/h, n=5–14 per group, p&lt;0.01). Myofilament sensitization by troponin mutations or EMD shortened the effective refractory period and the ventricular action potential of isolated perfused mouse and rabbit hearts, and caused early afterdepolarizations and triggered beats after fast pacing trains. The action potential shortening was attributable to increased cytosolic Ca 2+ buffering by the Ca 2+ sensitized myofilaments, which resulted in decreased systolic and increased end-diastolic Ca 2+ during fast pacing. Optical mapping demonstrated that Ca 2+ sensitization slowed the ventricular conduction velocity and increased the size of the vulnerable window for ventricular tachycardia both in mouse and rabbit hearts, resulting in a significantly higher incidence of sustained ventricular tachycardia in Ca 2+ sensitized compared with control hearts (5/6 vs 0/6, p&lt;0.05). Conclusion: Myofilament Ca 2+ sensitization alters Ca 2+ buffering to render hearts susceptible to ventricular arrhythmias by creating both an arrhythmogenic substrate and trigger. These results identify a novel mechanism linking sarcomeric mutations to susceptibility to ventricular arrhythmias and raise the prospect of a molecular approach to stratifying arrhythmia risk in HCM.
Margarine as a Butter Substitute.
Authors: Katharine Snodgrass
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CD8αα memory effector T cells descend directly from clonally expanded CD8α+βhigh TCRαβ T cells in vivo
Authors: Akihiro Konno, Kanae Okada, Kazunori Mizuno, Mika Nishida, Shuya Nagaoki, Tomoko Toma, Takahiro Uehara, Kazuhide Ohta, Yoshihito Kasahara, Hidetoshi Seki, Akihiro Yachie, Shoichi Koizumi
Journal: Blood (2002)
HYPOTHYROIDISM: A COMMON SYMPTOM
Authors: Roger I. Lee
Journal: Annals of Internal Medicine (1935)

Article1 December 1935HYPOTHYROIDISM: A COMMON SYMPTOMROGER I. LEE, M.D., F.A.C.P.ROGER I. LEE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-6-712 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe task to which I have set myself may be stated as follows: concentrating on a very small part of the endocrine system, I have tried with the aid of clinical tests and clinical experience to formulate some conclusions which are not at variance, I hope, with the best and soundest of theory and experimental data, and which have the virtue, I trust, of a firm basis on clinical facts. If anyone finds in this paper something exciting, fantastic or in the slightest degree revolutionary, I have signally failed in my purpose.Some of us can remember the eager search... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Read at the Philadelphia meeting of the American College of Physicians, April 30, 1935. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEmotions and the thyroid gland: A critical appraisalINDIVIDUAL VARIATIONS IN EXPENDITURE OF ENERGYKrankheiten der SchilddrüseBasal metabolism in rheumatic children 1 December 1935Volume 9, Issue 6Page: 712-716KeywordsEndocrine systemHypothyroidism ePublished: 1 December 2008 Issue Published: 1 December 1935 PDF downloadLoading ...
The Treatment of Acute Infectious Diseases.
Authors: Frank Sherman Meara
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3544: One year follow-up after acute Coronary Artery Disease (CAD) - Immediate hospital discharge vs. cardiac rehabilitation
Authors: Bernhard Schwaab, Annika Waldmann, Alexander Katalinic, Britta Poppe, Abdolhamid Sheikhzadeh, Heiner Raspe
Journal: Circulation (2007)

Background: The evidence of cardiac Rehab is not fully settled as meta-analysis mostly included studies without acute revascularisation and modern preventive medication. Method: In a multicentre randomised controlled trial, 1.474 patients (pts.) with acute CAD were included to investigate the impact of telemedicine on chronic CAD: 679 pts. were included immediately at discharge from the hospital (Hosp), 795 pts. after three week in-patient Rehab. All pts. had acute coronary angiography and were followed for one year. As Hosp pts. were included 11,3 ± 3 days (median 11) earlier than Rehab pts., events in the Hosp group were counted from day 12. Results: Rehab pts. were older (64 ±10 vs. 62 ±10 years; p&lt;.001), had more congestive heart failure (64 vs. 40%, p&lt;.001), renal insufficiency (10 vs. 7%, p=.036), hypercholesterolemia (79 vs. 74%, p=.023), and carotid stenosis (8 vs. 4%, p=.004). Telemedicine device prescription, gender, atrial fibrillation, peripheral artery disease, diabetes, hypertension, education and social status were similar in groups. After one year, Rehab pts. had more β-blockers (88 vs. 75%, p&lt;.001), ACE-inhibitors (81 vs. 70%, p&lt;.001), lower LDL-C (102 ±35 vs. 121 ±47 mg/dl, p&lt;.001) and a higher proportion of non-smokers (62 vs. 56%, p=.024). There was no difference in platelet inhibition, anticoagulation and statin therapy (81 vs. 79%). The primary combined endpoint of all-cause mortality, acute myocardial infarction (AMI), coronary revascularisation and hospitalisation occurred in 32.6% of Rehab pts. and in 38.7% of Hosp pts. (p=.014; absolute risk reduction (ARR) 0.0615, relative risk reduction (RRR) 16%, number needed to treat (NNT) 17). AMI (1.8 vs. 3.8%, p=.015; ARR 0.0207, RRR 54%, NNT 49) was reduced. Revascularisation (4.2 vs. 5.4%), hospitalisation (33.6 vs. 38.0%) and all-cause mortality (2.1 vs. 2.4%) were similar between groups. After multivariate analysis, the primary endpoint was still significant: OR 0.716 (95% CI 0.575–0.892; p=0.003) giving a RRR of 28% in favour of Rehab therapy. Conclusion: Although Rehab pts. were sicker at entry, cardiac Rehab substantially reduced relevant clinical endpoints within one year. With a very low NNT, Rehab is highly effective and should be advised to all suitable patients with acute CAD.
Psychoses associated with bupropion treatment
Authors: R N Golden, S P James, M A Sherer, M V Rudorfer, D A Sack, W Z Potter
Journal: American Journal of Psychiatry (1985)

The authors describe the development of acute psychoses in four patients treated with bupropion, a unicyclic aminoketone antidepressant. In two of the cases the psychoses seemed to be affected by dose. The mechanism responsible for the psychotic reactions is unclear, although it may involve perturbation of dopaminergic systems. On the basis of their experience, the authors offer recommendations regarding the clinical use of bupropion.
Abstract 4896: White-coat Hypertension and Left Ventricular Hypertrophy: Findings From the HARVEST Study
Authors: Lucio Mos, Pieralberto Visentin, Daniele D’este, Francesca Dorigatti, Stefano Martina, Olga Vriz, Massimo Santonastaso, Paolo Palatini
Journal: Circulation (2009)

White-coat hypertension (WCH) is considered a benign clinical condition, but recent studies indicate that patients with WCH may be at increased risk of events. Aim of this study was to evaluate the risk of left ventricular hypertophy (LVH) in this hypertension category in the population of HARVEST study: 470 never-treated young adults (330 men) with a mean age of 33.8 ± 8.5 years (range, 18 to 45 years), who were screened for stage 1 hypertension on at least two occasions, were enrolled. Patients were seen every six months for clinic blood pressure ( BP) and global risk assessment to determine which subjects developed hypertension needing drug therapy (HT). Echocardiographic left ventricular mass (LVM) and 24h ambulatory blood pressure (ABP) were measured at entry, every 5 years, and/or at the time of HT development before starting treatment. Subjects were divided according to whether they had WCH (n = 184) or sustained hypertension (SH, n = 286) at baseline. ABP and LVM measured at baseline and at the end of follow-up were used for analysis. LVH was defined as a LVM ≥50 g/m2.7 in men and ≥47 g/m2.7 in women. Results. During a 8.5 year follow-up, similar percents of subjects developed LVH (WCH, 8.2% vs SH, 6.3%, p = n.s.). LVM increased by 1.8 ± 6.4 g/m2.7 in WCH and by 0.7 ± 6.9 g/m2.7 in SH (p adjusted for age, sex, BMI, baseline LVM, and time = n.s.). ABP from baseline to study-end rose by 7.9 ± 10.8/5.6 ± 7.2 mmHg in WCH and by 1.2 ± 10.9/1.9 ± 7.9 mmHg in SH (adjusted p for WCH vs SH &lt; 0.000). WCH had a greater increase in ABP than SH also from the 3-month to the study-end measurement (+ 6.2 ± 9.7/4.3 ± 8.2 vs 2.4 ± 12.3/2.8 ± 8.6 mmHg, p = 0.009 for systolic BP, and p = 0.02 for diastolic BP). When data were adjusted also for baseline ABP, no significant difference emerged between WCH and SH for all comparisons. Conclusions. A greater increase in ABP and body weight and a similar susceptibility to develop LVH was observed in WCH compared to SH, suggesting that WCH should not be regarded as a benign condition. This implies an increased risk of cardiovascular events and prompts for a more tight clinical control along with target organ surveillance in WCH subjects.
Experiments on the Disposition of Acutely Inhaled C&lt;sup&gt;14&lt;/sup&gt;O&lt;sub&gt;2&lt;/sub&gt;
Authors: Austin M. Brues, Agnes N. Stroud
Journal: JNCI Journal of the National Cancer Institute (1955)

Experiments on the Disposition of Acutely Inhaled C14O2 Get access Austin M. Brues, Austin M. Brues Division of Biological and Medical Research, Argonne National Laboratory, Lemont, Ill. Search for other works by this author on: Oxford Academic PubMed Google Scholar Agnes N. Stroud Agnes N. Stroud Division of Biological and Medical Research, Argonne National Laboratory, Lemont, Ill. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 4, February 1955, Pages 1071–1076, https://doi.org/10.1093/jnci/15.4.1071 Published: 01 February 1955 Article history Received: 05 November 1954 Published: 01 February 1955
Abstract 14191: Obesity Index and the Risk of Atrial Fibrillation in an Urban Japanese Cohort: The Suita Study
Authors: Yoshihiro Kokubo, Wataru Shimizu, Shiro Kamakura, Makoto Watanabe, Akiko Kada, Katsuyuki Kawanishi, Yoshihiro Miyamoto
Journal: Circulation (2011)

Background and purpose: Atrial fibrillation (AF) is the most common chronic kind of arrhythmia and is associated with an increased risk of mortality and stroke. However, few prospective studies hav...