tbuckley/cabot-search huggingface dataset:
Medical defense.
Journal: BMJ (1977)

Medical Defence"That, as medical men may at any time become liable to false and groundless charges of a ruinous nature, it is most desirable that a Medical Defence Fund be formed and administered in connection with the British Medical Association, and that its members should be asked to contribute a small sum annually to this fund, those who do so becoming entitled, should occasion arise, to legal advice and assistance."'This resolution, adopted by the East Anglian Branch of the BMA in January 1886-three months after the foundation of the Medical Defence Union-was approved by 14 of the Association's 26 branches.2It was then considered by the Council but a year later rejected, as such work could not, apparently, be legally supported from BMA funds.Indeed, the MDU's foundation in the previous year had been held up while the BMA decided whether or not to take part in the new enterprise.Since then the Medical Protection Society has developed from its birth in 1892 as a splinter group of the MDU,2 and the Medical and Dental Defence Union of Scotland was founded in 1901, while on several other occasions the BMA has formally considered whether it should offer medical defence services to members.So the idea of the Association moving into defence had a long history by the time the ARM in London last year resolved: "That the Representative Body notes that in addition to the BMA subscription a member pays dues annually to the GMC and to one of three defence bodies.The Representative Body instructs the Council to
Relationship between clinical site and core lab assessments of perfusion and function on stress gated myocardial perfusion SPECT Sean W. Hayes, Leslee J. Shaw, Robert A. O'Rourke, William S. Weintraub, Koon K. Teo, Pamela Hartigan, William E. Boden, James Gerlach, Tara A. Gurtler, Kathryn Hanson, Guido Germano, Daniel S. Berman, COURAGE Investigators. Cedars-Sinai Medical Center, Los Angeles, CA
Journal: Journal of the American College of Cardiology (2001)
Thyroid Scintigraphy of a Rare Case of Left Thyroid Lobe Hemiagenesis With Subacute Thyroiditis
Authors: Nafisa Reya, David Posocco, Simin Dadparvar
Journal: Clinical Nuclear Medicine (2022)

Thyroid hemiagenesis is a rare developmental anomaly. Patients with thyroid hemiagenesis have higher incidence of coexisting thyroid disorders in the remaining lobe. We present a rare case of a 21-year-old woman with subclinical hyperthyroidism incidentally found to have thyroid hemiagenesis on thyroid 123I-Na scan, which is confirmed on thyroid ultrasound. On scintigraphy, only the right lobe showed activity. Thyroid ultrasound demonstrated that the right lobe was normal without any nodule. The left lobe was not visualized. This patient's thyroid uptake and scan also revealed low uptake in the remaining right thyroid lobe in keeping with subacute thyroiditis.
Abstract P114: Association of Subjective Social Status With Cardiovascular Health in Hispanics/Latinos
Authors: Lissette Piedra
Journal: Circulation (2018)

Introduction: Evidence suggests that subjective social status (SSS)—perceived status in the social hierarchy—may be more strongly associated with health than objective markers of social status (OSS), income and education. Compared to persons with high SSS, those with low SSS report poorer self-rated physical health and have higher rates of medical comorbidities. Little is known about the relationship between SSS and ideal cardiovascular health (CVH) profiles defined by the American Heart Association (AHA), particularly among diverse Hispanic/Latino adults. Hypothesis: Higher SSS will be associated with more favorable CVH profiles. Methods: We analyzed baseline HCHS/SOL data † on adults ages 18-74 in 2008-11 (N=15,440). SSS was assessed using the McArthur Scale, a 10-rung “social ladder” to specify social rank (scores range from 1-10; higher scores indicate higher SSS). CVH was defined based on levels of 7 metrics: diet, body mass index (BMI), physical activity, cholesterol, blood pressure, fasting glucose, and smoking status; levels of each metric were categorized as ideal, intermediate and poor using AHA criteria. A composite CVH score was calculated by summing across metrics (scores range from 0-14; higher scores indicate better CVH). Linear and logistic regressions were used to examine cross-sectional associations of SSS with CVH (overall and single metrics), after adjusting for OSS, demographics, Hispanic/Latino group, study center, marital status, insurance, prevalent coronary heart disease, and depressive symptoms (CESD). Results: In multivariate-adjusted models, each one unit increase in SSS* was associated with a higher overall CVH score (β = 0.03, 95% CI 0.004, 0.057, p &lt;0.05); higher SSS was also positively associated with ideal levels of BMI, physical activity, and fasting blood glucose levels (see Table 1). Conclusions: These findings suggest an association between SSS and CVH among diverse Hispanic/Latino adults. Future studies will explore the mechanisms through which SSS may influence CVH.
New frontiers in assessing outcomes for clinical trials: Implementation of computerized health status/utility assessment in the COURAGE trial John A. Spertus, Kate Hanson, Stanley E. Kaufman, Walton Sumner, Robert Nease, Sandra B. Dunbar, Pamela M. Hartigan, Robert A. O'Rourke, William S. Weintraub. Mid America Heart Institute, Kansas City, MO, Emory University, Atlanta, GA
Journal: Journal of the American College of Cardiology (2001)
Heberden Society: combined meeting, July 1979.
Authors: P Holt, R Clague, F Hay, L Nineham
Journal: Annals of the Rheumatic Diseases (1979)

The meeting consisted of (1) a symposium on the relevance of contemporary epidemiology to clinical rheumatology; (2) a scientific meeting consisting of 'free' papers selected by the societies; and (3) demonstrations which were intended to augment the scientific communications and to emphasise the shared aims and interests of health professionals and medically related industry.
The Authors Reply:
Authors: Kenichi Fujii, Hiroyuki Hao, Masahiko Shibuya, Takahiro Imanaka, Masashi Fukunaga, Kojiro Miki, Hiroto Tamaru, Hisashi Sawada, Yoshiro Naito, Mitsumasa Ohyanagi, Seiichi Hirota, Tohru Masuyama
Journal: JACC. Cardiovascular imaging (2016)
Prevalence and significance of exit block from multiple pulmonary veins in patients with paroxysmal atrial fibrillation Hakan Oral, Christian Sticherling, Robert L. Baker, Steven P. Chough, Kristina Wasmer, Hiroshi Tada, Frank Pelosi, Jr., Bradley P. Knight, S. Adam Strickberger, Fred Morady. University of Michigan, Ann Arbor, MI
Journal: Journal of the American College of Cardiology (2001)
Relationship of smoking with current and future social isolation and loneliness: 12-year follow-up of older adults in England
Authors: Keir EJ Philip, Feifei Bu, Michael I Polkey, Jamie Brown, Andrew Steptoe, Nicholas S Hopkinson, Daisy Fancourt
Journal: The Lancet Regional Health - Europe (2022)

Smoking is often colloquially considered "social". However, the actual relationship of smoking with current and future social isolation and loneliness is unclear. We therefore examined these relationships over a 12-year follow-up.
CHRONIC HYPOGLYCAEMIA
Authors: P. J. Cammidge
Journal: BMJ (1930)

DYSPEPSIA. acquired by trai giiig.Tli paiyo fiin el)sal y peiOilos o five to twvenity seconds are usutally found;(t.[il a siall :pi1o-pIOrtioll of the cases the re.spiratory symptoms so overshladow tlhe othier sniiiptolnis tliat cardliae (iisease is s11.c1(ted by patiellt aid.pliv-siciai .It is II-ell knlolw thlat tile dysp)eptie ofteni thlinks himivselif to he slufferin)g frIomii dlisease of time heart.H-owofteni do Wo f111( olli-selyes ,<Oviil(g: 'That is niot voir llheart, bint -oll.stomach `':.It is sollIetiimes liote(d thiat the patienit is still sceptical, especiallv if be is a plhysiciaii or has a. smattering, of mzedicineo (leri-ied fr01om the lay milanulals.He feels a paim wh-lere he kniowN-s hiis heart to be (duie to left triangularis or fifthl left interchondral), hie is s,lort of breath onl exertion, lhe oftei eNpleriences (lisordered actionI of tile hleart or palpitation, aild somlletimles las distinet slncolmll attacks.Is lhe to Imblme for silsleting his heart to h)e wrong?Oni-carefufl consideration tlhe lpatieilt is in the right.Time eardiologists hiave thrlow-ntlhe bIlame of hieart disease(fm e pry apt of the lheart anl vessels, bit have, so far, failed to remember tlat tihe leart anid vessels-thle circulila- toivr systemii of tile preseiit (lay-are lbnt a lhalf of the va,scular pumip.Tile heart alld vessels cani pumlip blood OnwV(ard(ls efficienitly if lhealtlhy a1(d if 0loo0( is sispplied to tielin, but tile heart, 1b itself, canniot get blood, to plump.TI'mle auixiliary pumpiij) is the respiratory lillllsculature, i-hiilil dlerivese;, or sucks, 10lood fromi tie oreat venous cisteriis to ilhe riglht auriclel.'llieii tile respliratorv pump is tilrowi-ll ou1t of alctioll tlie lieai-t wvill stop, uniless the body is in the horiziotal position, for' tlhein respiratolry suction is not iiecessary.The (climiber wh-lio falls oni tlle rope sooni sllccelillbs to syIlcope, as tlie rope tllrows time respiratory pllllllp outt of action; the labolratory r-abbit suspended in a vertic.alpositioi (lies of sylCoI)p in a fewi Illiiites, for tile i-eiglt of its abdomiinial viscerea and tIme poor tonie of its albdominal respiratory mu scles pIel-ent respiration.It was inoted above tbat tile low-er anlimllals lhave little or 110 thloracie respirationi.We have seeln that tlhe dys peptic frequently slhow-s esOiratory disability; he (locs ilot uise his abldominlal
T-independent antigen induces humoral memory through germinal centers
Authors: Xin Liu, Yongshan Zhao, Hai Qi
Journal: The Journal of Experimental Medicine (2022)

T-dependent humoral responses generate long-lived memory B cells and plasma cells (PCs) predominantly through germinal center (GC) reaction. In human and mouse, memory B cells and long-lived PCs are also generated during immune responses to T-independent antigen, including bacterial polysaccharides, although the underlying mechanism for such T-independent humoral memory is not clear. While T-independent antigen can induce GCs, they are transient and thought to be nonproductive. Unexpectedly, by genetic fate-mapping, we find that these GCs actually output memory B cells and PCs. Using a conditional BCL6 deletion approach, we show memory B cells and PCs fail to last when T-independent GCs are precluded, suggesting that the GC experience per se is important for programming longevity of T-independent memory B cells and PCs. Consistent with the fact that infants cannot mount long-lived humoral memory to T-independent antigen, B cells from young animals intrinsically fail to form T-independent GCs. Our results suggest that T-independent GCs support humoral memory, and GC induction may be key to effective vaccines with T-independent antigen.
Surgical Infections
Authors: John H. Wulsin
Journal: JAMA (1995)

In the past 25 years a full discussion of surgical infections has grown from sturdy sections of various surgical texts into a hefty volume of its own. The new information has derived largely from two sources: the explosion of knowledge about the structure and function of the infecting agents and about how they infect or can be prevented from doing damage; and the increasing prevalence of exotic infections, as surgical practice has extended into the realm of impaired immunity, as seen in cancer therapy, transplantation, shock, and HIV infection. Of course, traditional surgical infections remain, as always, the practitioner's chief adversary, and despite new understanding of invaders, more accurate diagnosis and more effective drugs, clinical skills in surgical intervention and in wound healing are still critical to gaining therapeutic success. "lifestyles of the infecting invaders" <i>Surgical Infections</i>, edited by Donald E. Fry, covers all corners of this sprawling field in
PSYCHO-ANALYSIS
Authors: S. J. Cole
Journal: BMJ (1917)

JA-N '-I I liseascs arc liolt due to bacilli.On the other hand, it hbas )enC loroved that many of the zymotic disease of men oild wiinials----for exiamplci, s-,wine fever, dongtu, typhuts, ~tud y; hlow fever--are caused by filtcr passers; thereforce Lic presum1lllption is that all zymuotic disease is due to fLiter ,)assers.Tfliese are mere hypotheses.which have to be estecd.In othier epidermnic diseases-niotably cholera.and
Injury, adventitial growth, and adventitial collagen density are not related with remodeling after balloon dilation in porcine arteries Freek J. van der Meer, Marion J. Sierevogel, Gerard Pasterkamp, Evelyn Velema, Arjan H. Schqneveld, Dominique P. V. de Kleijn, Cornelius Borst. Dept of Cardiology, University Medical Center Utrecht, G02-523, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
Journal: Journal of the American College of Cardiology (2001)
Phase 2, randomized multi oral immunotherapy with omalizumab ‘real life’ study
Authors: Sayantani B. Sindher, Divya Kumar, Shu Cao, Natasha Purington, Andrew Long, Vanitha Sampath, Stacey S. Zedeck, Margaret A. Woch, Maria Garcia‐Lloret, Rebecca Sharon Chinthrajah
Journal: Allergy (2022)

Abstract Background Oral immunotherapy (OIT) is frequently discontinued due to adverse events (AEs) and current data suggests that lowering OIT doses can minimize severity and frequency of AEs. However, the minimum daily dose that can enable desensitization and induce immune responses in multi‐food OIT (mOIT) is unknown. Methods Participants aged 2–25 years with multi‐food allergies were pretreated with fixed‐dose omalizumab (150 mg, 3 doses, every 4 weeks), and randomized 1:1 to receive mOIT to a total maintenance dose of either 300 or 1200 mg total protein, (total dose includes at least two and up to a max of five allergens) and then transitioned to real‐food protein equivalents after 18 weeks of treatment. The primary endpoint was the proportion of subjects with increases in IgG4/IgE ratio of at least 2 allergens by ≥25% from baseline after 18 weeks of therapy. The primary efficacy and safety analyses were done in the intention‐to‐treat population. Results Sixty participants were enrolled across two sites. Seventy percent of participants in both arms showed changes in sIgG4/sIgE ratio in at least 2 allergens with no difference between the treatment groups (OR [95% CI] = 1.00 [0.29, 3.49]). Overall, there were no differences in AEs between the 300 and 1200 mg groups (19% vs. 17%, p = .69), respectively. Conclusions Our data suggest that plasma marker changes are induced early, even at a total protein dose of 300 mg inclusive of multiple allergens when mOIT is combined with fixed‐dose omalizumab. Identification of optimal mOIT dosing with adjunct omalizumab is needed for the long‐term success of OIT. Trial Registration ClinicalTrials.gov (NCT03181009).
Abstract MP088: Relationship Between Daytime Sleepiness and Poor Physical Performance in Middle-aged Adults of the Bogalusa Heart Study
Authors: Benjamin D Pollock, Patrick Stuchlik, Jack Guralnik, Suzanne M Bertisch, Susan Redline, Wei Chen, Emily W Harville, Lydia A Bazzano
Journal: Circulation (2017)

Background: Studies conducted in elderly and frail adult populations, especially those with heart failure, have shown a consistent relationship between poor sleep and poor physical performance. Likewise, a similar association between poor sleep and lower performance has been found in extremely fit, elite athletes. However, this relationship has not been examined in healthy, middle-aged adult populations. Here, we test the cross-sectional association of daytime sleepiness with poor physical performance in our large, bi-racial cardiovascular cohort. Methods: From 2013-2016, 1,223 adults from the Bogalusa Heart Study attended follow-up visits to assess physical and cognitive performance and answer questionnaires pertaining to sleep habits. The Epworth Sleepiness Scale (ESS) was used to measure daytime sleepiness on an ordinal scale from 0-24. Short Physical Performance Battery (SPPB), which consists of chair stands, balance testing, and walk speed, was the outcome measure, with a score of &lt;10 out of 12 being considered poor physical performance. Multivariable logistic regression, adjusted for age, race, sex, sleep duration, employment status, BMI, and symptoms of sleep apnea was used to test the association between ESS [both continuously and dichotomized to abnormal (ESS&gt;10) vs. normal (ESS≤10)] and poor physical performance. Results: Our study population had a mean(SD) age of 48.1(5.2) and was 58.6% female and 34.7% black. Mean(SD) ESS was 6.3(4.7). 252 (20.6%) adults exhibited poor physical performance. After covariate adjustment, ESS was significantly associated with an increased risk of poor physical performance (Odds Ratio per 1 SD increase=1.17; 95% Confidence Interval=1.01-1.35; p =0.03). As a dichotomous exposure, an abnormal ESS resulted in a 53% increased risk of poor physical performance (OR=1.53; 95% CI=1.05-2.23; p =0.03). Conclusions: Even among relatively healthy middle-aged adults, daytime sleepiness appears to be associated with poor physical performance.
Travelogue
Authors: Daniel C. Bryant
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Questionable methods of cancer management: 'nutritional' therapies
Journal: CA A Cancer Journal for Clinicians (1993)

Although dietary measures may be helpful in preventing certain cancers, there is no scientific evidence that any nutritionally related regimen is appropriate as a primary treatment for cancer. This paper focuses on seven questionable modalities: vitamin C, pau d'arco tea, the Gerson diet, Hoxsey herbal therapy, the macrobiotic diet, Manner metabolic therapy, and Kelley metabolic therapy. Some of these approaches involve a diet that is nutritionally inadequate. Some involve potentially toxic doses of vitamins and/or other substances. Some are quite expensive. All pose the risk that patients who use them will abandon effective treatment. The American Cancer Society therefore recommends that "nutritional cancer cures" be avoided.
Absence of neointimal thickening following arterial injury in M-CSF-deficient mice and its reversal by local delivery of M-CSF highlights the critical role of M-CSF in neointima formation Ming Liu, Ning-Ning Chai, Arun Shukla, Sanjay Kaul, Prediman K. Shah, Bojan Cercek, Tripathi B. Rajavashisth. Cedars-Sinai Medical Center, Los Angeles, CA
Journal: Journal of the American College of Cardiology (2001)
A Comparison of Tacrolimus (FK 506) and Cyclosporine for Immunosuppression in Liver Transplantation
Authors: The U.S. Multicenter FK506 Liver Study Group
Journal: New England Journal of Medicine (1994)

Tacrolimus (FK 506), a macrolide compound isolated from a bacterium, is a potent immunosuppressant with activity in solid-organ transplants. Most immunosuppressive regimens for liver transplantation are based on cyclosporine.
Prospective Validation of the Prognostic Usefulness of B-Type Natriuretic Peptide in Asymptomatic Patients With Chronic Severe Aortic Regurgitation
Authors: Rodolfo Pizarro, Oscar O. Bazzino, Pablo F. Oberti, Mariano L. Falconi, Aníbal M. Arias, Juan G. Krauss, Arturo M. Cagide
Journal: Journal of the American College of Cardiology (2011)
Abstract P080: Glucose Homeostasis, Diabetes, and Orthostatic Hypotension in a Community-based Population: The ARIC Study
Authors: Stephen P Juraschek, Natalie Daya, A. Richey Sharrett, Elizabeth Selvin
Journal: Circulation (2018)

Background: Although orthostatic hypotension (OH) screening is recommended for adults with diabetes, the extent to which blood glucose (BG) levels are associated with OH has not been characterized. Hypothesis: Higher BG levels are associated with having OH, while low levels of BG are not associated with OH. Methods: We examined the cross-sectional association of OH with BG and diabetes status in middle-aged (range 44 to 66 yrs) ARIC participants (1987-1989). OH was defined as a drop in blood pressure (systolic ≥20 mm Hg or diastolic ≥10 mm Hg) within 2 min of standing, when transitioning from the supine to standing position. Using logistic regression, we examined the association of the following 5 categories of BG without diabetes or diabetes and OH: (1) low-normal BG (fasting BG &lt;80 or non-fasting BG &lt;100 mg/dL), (2) high-normal BG (fasting BG of 80-99 or non-fasting BG of 100-139 mg/dL), (3) pre-diabetes (fasting BG of 100-125 or non-fasting BG of 140-199 mg/dL), (4) undiagnosed diabetes (fasting BG ≥126 or non-fasting BG ≥200 mg/dL), or (5) diabetes (self-reported diagnosis or current medication use). We also modeled BG as a continuous variable by diabetes status, using restricted cubic splines to characterize the association between BG level and OH. Results: In 12,636 participants (mean age 54.6 ± 5.7 yrs, 55% women, 26% black), 4.3% had OH at baseline. The mean BG was 108 ± 38 mg/dL; 7% had diabetes (self-reported diagnosis or diabetes medications). After adjustment, adults with low BG (group 1) or diabetes (group 5) were both more likely to have OH compared to the normal BG group (group 2) with ORs of 2.15 (95% CI: 1.26, 3.65) and 2.20 (95% CI: 1.65, 2.92), respectively. Continuous characterization of the relationship between BG and OH was U-shaped for participants with or without diabetes ( Figure, panels A&amp;B ). Conclusions: Low BG in adults without diabetes, diabetes, and high BG in adults with diabetes were associated with OH. This suggests a more prominent role for BG homeostasis in blood pressure stabilization with standing.
Medical News.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal