tbuckley/cabot-search huggingface dataset:
Medical Education and State Boards of Registration
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Kidney Outcomes in Long COVID
Authors: Benjamin Bowe, Yan Xie, Evan Xu, Ziyad Al-Aly
Journal: Journal of the American Society of Nephrology (2021)

COVID-19 is associated with increased risk of post-acute sequelae involving pulmonary and extrapulmonary organ systems-referred to as long COVID. However, a detailed assessment of kidney outcomes in long COVID is not yet available.We built a cohort of 1,726,683 US Veterans identified from March 1, 2020 to March 15, 2021, including 89,216 patients who were 30-day survivors of COVID-19 and 1,637,467 non-infected controls. We examined risks of AKI, eGFR decline, ESKD, and major adverse kidney events (MAKE). MAKE was defined as eGFR decline ≥50%, ESKD, or all-cause mortality. We used inverse probability-weighted survival regression, adjusting for predefined demographic and health characteristics, and algorithmically selected high-dimensional covariates, including diagnoses, medications, and laboratory tests. Linear mixed models characterized intra-individual eGFR trajectory.Beyond the acute illness, 30-day survivors of COVID-19 exhibited a higher risk of AKI (aHR, 1.94; 95% CI, 1.86 to 2.04), eGFR decline ≥30% (aHR, 1.25; 95% CI, 1.14 to 1.37), eGFR decline ≥40% (aHR, 1.44; 95% CI, 1.37 to 1.51), eGFR decline ≥50% (aHR, 1.62; 95% CI, 1.51 to 1.74), ESKD (aHR, 2.96; 95% CI, 2.49 to 3.51), and MAKE (aHR, 1.66; 95% CI, 1.58 to 1.74). Increase in risks of post-acute kidney outcomes was graded according to the severity of the acute infection (whether patients were non-hospitalized, hospitalized, or admitted to intensive care). Compared with non-infected controls, 30-day survivors of COVID-19 exhibited excess eGFR decline (95% CI) of -3.26 (-3.58 to -2.94), -5.20 (-6.24 to -4.16), and -7.69 (-8.27 to -7.12) ml/min per 1.73 m2 per year, respectively, in non-hospitalized, hospitalized, and those admitted to intensive care during the acute phase of COVID-19 infection.Patients who survived COVID-19 exhibited increased risk of kidney outcomes in the post-acute phase of the disease. Post-acute COVID-19 care should include attention to kidney disease.
Pulmonary embolism
Authors: Menno V. Huisman, Stefano Barco, Suzanne C. Cannegieter, Gregoire Le Gal, Stavros V. Konstantinides, Pieter H. Reitsma, Marc Rodger, Anton Vonk Noordegraaf, Frederikus A. Klok
Journal: Nature Reviews Disease Primers (2018)
Identifying Suicide Risk in Adolescents and Young Adults With Type 1 Diabetes: Are Depression Screeners Sufficient?
Authors: Ashley C. Moss, Alissa J. Roberts, Joyce P. Yi-Frazier, Kendra L. Read, Craig E. Taplin, Kathryn W. Weaver, Catherine Pihoker, Irl B. Hirsch, Faisal S. Malik
Journal: Diabetes Care (2022)

OBJECTIVE Examine the utility of suicide-risk items embedded within depression screeners for identifying the presence of suicide risk in adolescents and young adults (AYA) with type 1 diabetes. RESEARCH DESIGN AND METHODS Sensitivity, specificity, and predictive value of self-report of suicide risk on the Patient Health Questionniaire-9 (PHQ-9) were compared with the pediatric psychologist–administered Columbia-Suicide Severity Rating Scale (C-SSRS) as the reference standard for AYA with type 1 diabetes seen in a multidisciplinary AYA Diabetes Program clinic. RESULTS Of 133 participants, 9.8% and 11.3% reported suicide risk on the PHQ-9 and C-SSRS, respectively. Sensitivity of the PHQ-9 risk item was 53.3% (95% CI 27.4%–77.7%), specificity was 95.7% (95% CI 89.9%–98.4%), positive predictive value was 61.5% (95% CI 32.3%–84.9%), and negative predictive value was 94.2% (95% CI 87.9–97.4%). CONCLUSIONS Depression screeners appear to under-identify AYA with type 1 diabetes who may otherwise be at risk for suicide.
GestaltMatcher facilitates rare disease matching using facial phenotype descriptors
Authors: Tzung-Chien Hsieh, Aviram Bar-Haim, Shahida Moosa, Nadja Ehmke, Karen W. Gripp, Jean Tori Pantel, Magdalena Danyel, Martin Atta Mensah, Denise Horn, Stanislav Rosnev, Nicole Fleischer, Guilherme Bonini, Alexander Hustinx, Alexander Schmid, Alexej Knaus, Behnam Javanmardi, Hannah Klinkhammer, Hellen Lesmann, Sugirthan Sivalingam, Tom Kamphans, Wolfgang Meiswinkel, Frédéric Ebstein, Elke Krüger, Sébastien Küry, Stéphane Bézieau, Axel Schmidt, Sophia Peters, Hartmut Engels, Elisabeth Mangold, Martina Kreiß, Kirsten Cremer, Claudia Perne, Regina C. Betz, Tim Bender, Kathrin Grundmann-Hauser, Tobias B. Haack, Matias Wagner, Theresa Brunet, Heidi Beate Bentzen, Luisa Averdunk, Kimberly Christine Coetzer, Gholson J. Lyon, Malte Spielmann, Christian P. Schaaf, Stefan Mundlos, Markus M. Nöthen, Peter M. Krawitz
Journal: Nature Genetics (2022)
Achalasia
Authors: Guy E Boeckxstaens, Giovanni Zaninotto, Joel E Richter
Journal: The Lancet (2013)

Achalasia is a rare motility disorder of the oesophagus characterised by loss of enteric neurons leading to absence of peristalsis and impaired relaxation of the lower oesophageal sphincter. Although its cause remains largely unknown, ganglionitis resulting from an aberrant immune response triggered by a viral infection has been proposed to underlie the loss of oesophageal neurons, particularly in genetically susceptible individuals. The subsequent stasis of ingested food not only leads to symptoms of dysphagia, regurgitation, chest pain, and weight loss, but also results in an increased risk of oesophageal carcinoma. At present, pneumatic dilatation and Heller myotomy combined with an anti-reflux procedure are the treatments of choice and have comparable success rates. Per-oral endoscopic myotomy has recently been introduced as a new minimally invasive treatment for achalasia, but there have not yet been any randomised clinical trials comparing this option with pneumatic dilatation and Heller myotomy.
Recommended Childhood Immunization Schedule—United States, 2000
Journal: JAMA (2000)

EACH YEAR, CDC'S ADVISORY COMMITtee on Immunization Practices (ACIP) reviews the recommended childhood immunization schedule to ensure it remains current with changes in manufacturers' vaccine formulations, revisions in recommendations for the use of licensed vaccines, and recommendations for newly licensed vaccines.This report presents the recommended childhood immunization schedule for 2000 and explains the changes that have occurred since January 1999.Since the publication of the immunization schedule in January 1999, 1 ACIP, the American Academy of Family Physicians, and the American Academy of Pediatrics have recommended removal of rotavirus vaccine from the schedule, endorsed an all-inactivated poliovirus vaccine (IPV) schedule for polio vaccination, recommended exclusive use of acellular pertussis vaccines for all doses of the pertussis vaccine series, and added hepatitis A vaccine (Hep A) to the schedule to reflect its recommended use in selected geographic areas. 2 Detailed recommendations for using vaccines are available from the manufacturers' package inserts, ACIP statements on specific vaccines, and the 1997 Red Book. 3 ACIP statements for each recommended childhood vaccine can be viewed, downloaded, and printed at CDC's National Immunization Program World-Wide Web site, http://www.cdc.gov/nip/publications/acip-list.htm. Removal of Rotavirus Vaccine From the ScheduleOn October 22, 1999, ACIP recommended that Rotashield * (rhesus rotavirus vaccine-tetravalent [RRV-TV]) (Wyeth Laboratories, Inc., Marietta, Pennsylvania), the only U.S. licensed rotavirus vaccine, no longer be used in the United States. 4The decision was based on the results of an expedited review of scientific data presented to ACIP by CDC.Data from the review indicated a strong association between RRV-TV and intussusception among infants 1-2 weeks following vaccination.Vaccine use was suspended in July pending the ACIP data review.Parents should be reassured that children who received the rotavirus vaccine before July are not at increased risk for intussusception now.The manufacturer withdrew the vaccine from the market in October. Inactivated Poliovirus Vaccine for All Four Doses
The prevalence of loneliness across 113 countries: systematic review and meta-analysis
Authors: Daniel L Surkalim, Mengyun Luo, Robert Eres, Klaus Gebel, Joseph van Buskirk, Adrian Bauman, Ding Ding
Journal: BMJ (2022)

Abstract Objectives To identify data availability, gaps, and patterns for population level prevalence of loneliness globally, to summarise prevalence estimates within World Health Organization regions when feasible through meta-analysis, and to examine temporal trends of loneliness in countries where data exist. Design Systematic review and meta-analysis. Data sources Embase, Medline, PsycINFO, and Scopus for peer reviewed literature, and Google Scholar and Open Grey for grey literature, supplemented by backward reference searching (to 1 September 2021) Eligibility criteria for selecting studies Observational studies based on nationally representative samples (n≥292), validated instruments, and prevalence data for 2000-19. Two researchers independently extracted data and assessed the risk of bias using the Joanna Briggs Institute checklist. Random effects meta-analysis was conducted in the subset of studies with relatively homogeneous research methods by measurement instrument, age group, and WHO region. Results Prevalence data were available for 113 countries or territories, according to official WHO nomenclature for regions, from 57 studies. Data were available for adolescents (12-17 years) in 77 countries or territories, young adults (18-29 years) in 30 countries, middle aged adults (30-59 years) in 32 countries, and older adults (≥60 years) in 40 countries. Data for all age groups except adolescents were lacking outside of Europe. Overall, 212 estimates for 106 countries from 24 studies were included in meta-analyses. The pooled prevalence of loneliness for adolescents ranged from 9.2% (95% confidence interval 6.8% to 12.4%) in South-East Asia to 14.4% (12.2% to 17.1%) in the Eastern Mediterranean region. For adults, meta-analysis was conducted for the European region only, and a consistent geographical pattern was shown for all adult age groups. The lowest prevalence of loneliness was consistently observed in northern European countries (2.9%, 1.8% to 4.5% for young adults; 2.7%, 2.4% to 3.0% for middle aged adults; and 5.2%, 4.2% to 6.5% for older adults) and the highest in eastern European countries (7.5%, 5.9% to 9.4% for young adults; 9.6%, 7.7% to 12.0% for middle aged adults; and 21.3%, 18.7% to 24.2% for older adults). Conclusion Problematic levels of loneliness are experienced by a substantial proportion of the population in many countries. The substantial difference in data coverage between high income countries (particularly Europe) and low and middle income countries raised an important equity issue. Evidence on the temporal trends of loneliness is insufficient. The findings of this meta-analysis are limited by data scarcity and methodological heterogeneity. Loneliness should be incorporated into general health surveillance with broader geographical and age coverage, using standardised and validated measurement tools. Systematic review registration PROSPERO CRD42019131448.
571. Downregulation of CCR5 and Inhibition of HIV-1 with RNAi, Ribozyme and Single Chain Fv Antibody Delivered by SV40-Derived Vectors To Protect CCR5-Expressing Primary Cells: Monocyte-Derived Macrophages and Microglial Cells from R5-Tropic HIV-1
Journal: Molecular Therapy (2007)
Correction: Real-time identification of gastric lesions and anatomical landmarks by artificial intelligence during magnetically controlled capsule endoscopy
Authors: Jun Pan, Ji Xia, Bin Jiang, Hang Zhang, Hao Zhang, Zhao-Shen Li, Zhuan Liao
Journal: Endoscopy (2022)

Correction to: Real-time identification of gastric lesions and anatomical landmarks by artificial intelligence during magnetically controlled capsule endoscopyEndoscopy eFirstDOI: 10.1055/a-1724-6958
Genotoxic aldehydes in the hematopoietic system
Authors: Meng Wang, Felix A. Dingler, K. J. Patel
Journal: Blood (2022)

Reactive aldehydes are potent genotoxins that threaten the integrity of hematopoietic stem cells and blood production. To protect against aldehydes, mammals have evolved a family of enzymes to detoxify aldehydes, and the Fanconi anemia DNA repair pathway to process aldehyde-induced DNA damage. Loss of either protection mechanisms in humans results in defective hematopoiesis and predisposition to leukemia. This review will focus on the impact of genotoxic aldehydes on hematopoiesis, the sources of endogenous aldehydes, and potential novel protective pathways.
THU0505 Associations Between Measures of Obesity over 10 Years and Patella Cartilage in a Population-Based Cohort of Young to Middle Aged, Asymptomatic Women
Authors: A. Gunardi, S. Brennan, Y. Wang, F. Cicuttini, J. Pasco, M. Kotowicz, G. Nicholson, A. Wluka
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Osteoarthritis most commonly affects the patellofemoral compartment of the knee, being a major cause of pain and disability. The structural changes that evolve prior to the onset of symptoms can be visualised using magnetic resonance imaging (MRI). There is little known about the role of obesity on the early structural changes in the patella cartilage in younger, asymptomatic adult females. <h3>Objectives</h3> The objective of this study was to examine the relationship between patella cartilage and obesity and change in obesity over the previous 10 years. <h3>Methods</h3> 160 asymptomatic women (20-49years) participating in the Geelong Osteoporosis Study underwent knee MRI between 2006-8. Weight and body mass index (BMI) were measured 10 years prior (1994-7, baseline) and at the time of the MRI (current) with change over the period calculated (current-baseline). The relationships between the measures of obesity and patella cartilage volume and defects were examined. <h3>Results</h3> After adjustment for age and patella bone volume, there was a reduction of 13 (95% CI -25.7, -0.55) microliters (mL) in patella cartilage volume for every 1 unit increase in current BMI and reduction of 27mL (95% CI -52.6, -1.5) per BMI unit increase over 10 years (<i>p</i>=0.04 for both). There was no significant association between baseline BMI and patella cartilage volume (<i>p</i>=0.16). Increased baseline and current weight and BMI were associated with increased prevalence of patella cartilage defects (all <i>p</i>&lt;0.001). <h3>Conclusions</h3> Obesity and weight gain over midlife are both associated with detrimental structural change at the patella in young to middle aged healthy women without clinical osteoarthritis. Maintaining a healthy weight, avoiding obesity and weight gain in younger asymptomatic women may be important in the prevention of patellofemoral osteoarthritis. <h3>Disclosure of Interest</h3> None Declared
Erythropoietic protoporphyria
Authors: D.J. TODD
Journal: British Journal of Dermatology (1994)

Erythropoietic protoporphyria (EPP) is an inherited inborn error of porphyrin metabolism caused by decreased activity of the enzyme ferrochelatase, the terminal enzyme of the haem biosynthetic pathway, which catalyses the insertion of iron into protoporphyrin to form haem. EPP is characterized clinically by photosensitivity to visible light commencing in childhood, and biochemically by elevated red cell protoporphyrin levels. Although the majority of papers and reviews have classified EPP as an autosomal dominant disorder, the inheritance has now been shown to be more complex, and both autosomal dominant and recessive patterns of inheritance have been demonstrated using ferrochelatase activity. Further molecular studies should clarify the exact mode of inheritance. It seems likely that in the majority of families a defective allele from the apparently normal parent will be required for disease expression, but another possibility is autosomal dominant inheritance with low clinical penetrance. Exposure to bright sunlight, for as little as a few minutes in the worst affected patients, causes burning pain in exposed skin, which may be so severe and persistent that it prevents sleep for several nights. Patients usually attempt to relieve the pain by cold water or cold compresses. Apart from sun avoidance, the mainstay of prophylactic treatment has been beta-carotene. Although the published evidence for the effectiveness of beta-carotene is impressive, no controlled trials using adequate doses have been performed to unequivocally confirm its usefulness. The most serious complication of EPP is acute hepatic failure, which is due to accumulation of protoporphyrin in the liver. If jaundice develops, a rapidly fatal outcome often follows, unless liver transplantation is undertaken. Regular monitoring of liver function and red cell porphyrin levels is advisable, but this does not always identify patients before serious liver damage has occurred. Even when patients are identified at an early stage in the development of liver disease the therapeutic options available to prevent further damage are limited, and have not been fully evaluated. The gene for ferrochelatase has been cloned, sequenced and mapped to the long arm of chromosome 18. As mutations continue to be identified, phenotype/genotype correlations should become apparent, and it may eventually be possible to identify those patients at risk of developing hepatic failure. In addition, as the basic enzymatic defect in EPP is at the level of the bone marrow stem cells, which are the target cells of choice in the development of retroviral-mediated gene transfer, definitive treatment of EPP by gene therapy is a distinct hope for the future.(ABSTRACT TRUNCATED AT 400 WORDS)
Manuscripts Approved for JNCI, December 1, 1969, to January 1, 1970
Journal: JNCI Journal of the National Cancer Institute (1970)

Manuscripts Approved for JNCI, December 1, 1969, to January 1, 1970 JNCI: Journal of the National Cancer Institute, Volume 44, Issue 2, February 1970, Pages 485–487, https://doi.org/10.1093/jnci/44.2.485-b Published: 01 February 1970
Miscellanea Medica
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Calcified and Noncalcified Coronary Plaques and Atherosclerotic Cardiovascular Events in Patients With Severe Hypercholesterolemia—Moving Forward With Risk Stratification and Therapy
Authors: Raul D. Santos
Journal: JAMA Network Open (2022)

Martin Bødtker Mortensen, MD, PhD; Miguel Caínzos-Achirica, MD, MPH, PhD; Flemming Hald Steffensen, MD, PhD; Hans Erik Bøtker, MD, DMSc; Jesper Møller Jensen, MD, PhD; Niels Peter Rønnow Sand, MD, PhD; Michael Maeng, MD, PhD; Jens Meldgaard Bruun, MD, PhD; Michael J. Blaha, MD, MPH; Henrik Toft Sørensen, MD, DMSc; Manan Pareek, MD, PhD; Khurram Nasir, MD, MPH, MSc; Bjarne L. Nørgaard, MD, PhD
ACCF/AHA/ACP/HFSA/ISHLT 2010 Clinical Competence Statement on Management of Patients With Advanced Heart Failure and Cardiac Transplant
Authors: Gary S. Francis, Barry H. Greenberg, Daphne T. Hsu, Brian E. Jaski, Mariell Jessup, Martin M. LeWinter, Francis D. Pagani, Ileana L. Piña, Marc J. Semigran, Mary Norine Walsh, David H. Wiener, Clyde W. Yancy
Journal: Circulation (2010)
Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2007
Authors: D E Furst, F C Breedveld, J R Kalden, J S Smolen, G R Burmester, J Sieper, P Emery, E C Keystone, M H Schiff, P Mease, P L C M van Riel, R Fleischmann, M H Weisman, M E Weinblatt
Journal: Annals of the Rheumatic Diseases (2007)

Rheumatoid arthritis and juvenile idiopathic arthritisTNF blocking agents, when given up to the maximum approved dosing regimens for RA and juvenile idiopathic arthritis of the polyarthritic variety, are expected to lead to significant, documentable improvement in symptoms, signs and/or laboratory parameters within 12 weeks (Category A andB evidence 6- 10 12-20 22 24-29 31-37 56 80-93 ).There is no evidence that any one TNF Consensus statement on biological agents iii3
Gastroenterology
Authors: Howard M. Spiro
Journal: JAMA (1976)

This is a good book, for the most part completely rewritten by many experts under the direction of Dr Bockus and his five associate editors, Berk, Haubrich, Kalser, Roth, and Vildardell. Inevitably, there is some unevenness—eg, 16 pages are devoted to chronic duodenal stasis and none as such to ischemic bowel disease, which received mention only in the differential diagnosis of inflammatory bowel disease. On the whole, however, the conscientious reader can expect to find almost everything he needs to know—and sometimes more than he will need to know—about most disorders of the small intestine and colon. Although there is still a little more historical information than the busy physician needs, the elephantine bibliographies of previous editions have for the most part gone their way. The book is up to date in almost every area, with recent references and careful evaluation of the explosion in diagnostic technology. More important, experienced
Erratum to ‘High-quality endoscope reprocessing decreases endoscope contamination’ [Clinical Microbiology and Infection, Volume 24, Issue 10 (October 2018) Pages 1101.e1–1101.e6]
Authors: P. Decristoforo, J. Kaltseis, A. Fritz, M. Edlinger, W. Posch, D. Wilflingseder, C. Lass-Flörl, D. Orth-Höller
Journal: Clinical Microbiology and Infection (2019)