tbuckley/cabot-search huggingface dataset:
Rescue from Pseudomonas aeruginosa Airway Infection via Stem Cell Transplantation
Authors: Kerstin Brinkert, Silke Hedtfeld, Annina Burhop, Rena Gastmeier, Pauline Gad, Dirk Wedekind, Christina Kloth, Justin Rothschuh, Nico Lachmann, Miriam Hetzel, Adan Chari Jirmo, Elena Lopez-Rodriguez, Christina Brandenberger, Gesine Hansen, Axel Schambach, Mania Ackermann, Burkhard Tümmler, Antje Munder
Journal: Molecular Therapy (2020)

Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which lead to impaired ion transport in epithelial cells. Although lung failure due to chronic infection is the major comorbidity in individuals with cystic fibrosis, the role of CFTR in non-epithelial cells has not been definitively resolved. Given the important role of host defense cells, we evaluated the Cftr deficiency in pulmonary immune cells by hematopoietic stem cell transplantation in cystic fibrosis mice. We transplanted healthy bone marrow stem cells and could reveal a stable chimerism of wild-type cells in peripheral blood. The outcome of stem cell transplantation and the impact of healthy immune cells were evaluated in acute Pseudomonas aeruginosa airway infection. In this study, mice transplanted with wild-type cells displayed better survival, lower lung bacterial numbers, and a milder disease course. This improved physiology of infected mice correlated with successful intrapulmonary engraftment of graft-derived alveolar macrophages, as seen by immunofluorescence microscopy and flow cytometry of graft-specific leucocyte surface marker CD45 and macrophage marker CD68. Given the beneficial effect of hematopoietic stem cell transplantation and stable engraftment of monocyte-derived CD68-positive macrophages, we conclude that replacement of mutant Cftr macrophages attenuates airway infection in cystic fibrosis mice.
Response to Letter to the Editor: Efficacy and Safety of Sintilimab Plus Pemetrexed and Platinum as First-Line Treatment for Locally Advanced or Metastatic Nonsquamous NSCLC: A Randomized, Double-Blind, Phase 3 Study (ORIENT-11)
Authors: Yunpeng Yang, Hui Zhou, Li Zhang
Journal: Journal of Thoracic Oncology (2020)
Boiled or Bottled: Regional and Seasonal Exposures to Drinking Water Contamination and Household Air Pollution in Rural China
Authors: Alasdair Cohen, Ajay Pillarisetti, Qing Luo, Qi Zhang, Hongxing Li, Gemei Zhong, Gang Zhu, John M. Colford, Kirk R. Smith, Isha Ray, Yong Tao
Journal: Environmental Health Perspectives (2020)

Background: Inadequate access to safe drinking water remains a global health problem, particularly in rural areas. Boiling is the most commonly used form of point-of-use household water treatment (HWT) globally, although the use of bottled water in low- and middle-income countries (LMICs) is increasing rapidly. Objectives: We assessed the regional and seasonal prevalence of HWT practices (including bottled water use) in low-income rural areas in two Chinese provinces, evaluated the microbiological safety of drinking water and associated health outcomes, and estimated the air pollution burden associated with the use of solid fuels for boiling. Methods: We conducted cross-sectional surveys and collected drinking water samples from 1,033 rural households in Guangxi and Henan provinces. Temperature sensors affixed to pots and electric kettles were used to corroborate self-reported boiling frequencies and durations, which were used to model household air pollution (HAP) in terms of estimated particulate matter ≤2.5μm in aerodynamic diameter (PM2.5) concentrations. Results: Based on summer data collection in both provinces, after controlling for covariates, boiling with electric kettles was associated with the largest log reduction in thermotolerant coliforms (TTCs) (−0.66 log10 TTC most probable number/100mL), followed by boiling with pots (−0.58), and bottled water use (−0.39); all were statistically significant (p<0.001). Boiling with electric kettles was associated with a reduced risk of TTC contamination [risk ratio (RR)=0.25, p<0.001] and reported diarrhea (RR=0.80, p=0.672). TTCs were detected in 51% (n=136) of bottled water samples. For households boiling with biomass, modeled PM2.5 concentrations averaged 79 μg/m3 (standard deviation=21). Discussion: Our findings suggest that where boiling is already common and electricity access is widespread, the promotion of electricity-based boiling may represent a pragmatic stop-gap means of expanding safe water access until centralized, or decentralized, treated drinking water is available; displacing biomass use for water boiling could also reduce HAP concentrations and exposures. Our results also highlight the risks of increasing bottled water use in rural areas, and its potential to displace other sources of safe drinking water, which could in turn hamper efforts in China and other LMICs toward universal and affordable safe water access. https://doi.org/10.1289/EHP7124
Multidrug-loaded electrospun micro/nanofibrous membranes: Fabrication strategies, release behaviors and applications in regenerative medicine
Authors: Xingzi Lan, Han Wang, Jianfu Bai, Xiaomin Miao, Quan Lin, Jianpei Zheng, Shukai Ding, Xiaoran Li, Yadong Tang
Journal: Journal of Controlled Release (2020)
Universal Suicide Prevention for Health Care Professionals
Authors: Michael Schoenbaum, Rajeev Ramchand
Journal: JAMA Surgery (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Abstract 15384: Hematologic Changes, Particularly Rising Red Cell Distribution Width, Precede Pulmonary Arterial Hypertension (PAH) Diagnosis
Authors: Timothy E Thayer, Eric Farber-Eger, Evan Brittain
Journal: Circulation (2019)

Introduction: Red cell distribution width (RDW) and iron deficiency are strongly associated with PAH diagnosis and prognosis, but the longitudinal relationship of clinical hematologic variables and...
16466 Predictors of maintenance of response in patients with moderate to severe atopic dermatitis after oral Janus kinase 1 selective inhibitor abrocitinib interruption
Authors: Melinda J. Gooderham, Giampiero Girolomoni, Julian O’Neil Moore, Jonathan I. Silverberg, Madelyn Curto, Weidong Zhang, Marco DiBonaventura, Hernan Valdez, Hernan Valdez
Journal: Journal of the American Academy of Dermatology (2020)
Will Targeting Interleukin-6 in the Anemia of CKD Change Our Treatment Paradigm?
Authors: Daniel W. Coyne, Robert Fleming
Journal: Journal of the American Society of Nephrology (2020)

Anemia of CKD is multifactorial, with major contributors including erythropoietin deficiency, absolute and functional iron deficiency, and inflammation. Clinical management has largely neglected inflammation, administering erythropoiesis-stimulating agents (ESA) and iron instead. Most patients on
17090 Characterization of the ocular rosacea in a dermatologic center in Bogota, Colombia
Authors: David Alfredo Castillo Molina, Clara A. Quiroga L, Luis Daniel Holguin, Z. Diego M. Martinez, Yensi Lorena Romero Diaz, Jennipher Andrea Blanco Gomez, Maria José Centeno, Paula Dubeibe, David E. Castillo
Journal: Journal of the American Academy of Dermatology (2020)
Risk Factors for Mortality after COVID-19 in Patients with Preexisting Interstitial Lung Disease
Authors: Laure Gallay, Yurdagül Uzunhan, Raphael Borie, Romain Lazor, Pierre Rigaud, Sylvain Marchand-Adam, Sandrine Hirschi, Dominique Israel-Biet, Victor Valentin, Vincent Cottin
Journal: American Journal of Respiratory and Critical Care Medicine (2020)

Interestingly, we successfully isolated infectious virus from five of five samples from patients with Tx (obtained 4-28 d after admission to the ICU), but, in line with data from Wölfel and colleagues (9), we were unable to detect infectious virus after Day 7 in immunocompetent control patients (zero of four patients).Limitations.First, the sample size of our study is limited, but the significant findings with potential major impact on patient management are of great importance.Second, three patients remained under intensive care treatment on the day of data censoring, resulting in an unknown outcome.Third, some cases had incomplete documentation of clinical data, missing laboratory-testing results, or both.Conclusions.To our knowledge, this is the first comprehensive report on COVID-19 in patients with a history of HSCT that focuses on virological parameters.In these patients, as compared with immunocompetent patients, prolonged shedding of infectious virus, viremia, and high viral loads in respiratory samples highlight the need of the immune system for viral control but also indicate virus-induced mortality and a higher risk for transmission to other patients and medical staff.
Effects of Geographic Redistribution Policy on Access to Organ Transplant
Authors: Kevin O’Connor, Alexandra K. Glazier, Howard Nathan
Journal: JAMA Surgery (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
18856 The association between atopic dermatitis and hypertension: A systematic review and meta-analysis
Authors: Muhammad Yousaf, Marissa Ayasse, Adnan Ahmed, Eran C. Gwillim, Sherief R. Janmohamed, Kevin R. Patel, Jacob P. Thyssen, Jonathan I. Silverberg
Journal: Journal of the American Academy of Dermatology (2020)
Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Emerging Risk Factors Collaboration, Sarwar N, Gao P, Seshasai SR, Gobin R, Kaptoge S, Di Angelantonio E, Ingelsson E, Lawlor DA, Selvin E, Stampfer M, Stehouwer CD, Lewington S, Pennells L, Thompson A, Sattar N, White IR, Ray KK, Danesh J.
Authors: Reijo Tilvis
Journal: The Lancet (2010)
日本人における心血管死亡率に対する時計方向回転と反時計方向回転の予後的価値(NIPPON DATA80の24年間追跡調査)
Authors: Nakamura Yasuyuki, Okamura Tomonori, Higashiyama Aya, Watanabe Makoto, Kadota Aya, Ohkubo Takayoshi, Miura Katsuyuki, Kasagi Fumiyoshi, Kodama Kazunori, Okayama Akira, Ueshima Hirotsugu
Journal: Circulation (2012)
Perioperative Cannabis as a Potential Solution for Reducing Opioid and Benzodiazepine Dependence
Authors: Camille Stewart, Yuman Fong
Journal: JAMA Surgery (2020)

Cannabis is increasingly being used for medicinal purposes but remains outside Western medical practice. Data on perioperative use and outcomes are scarce. Few surgeons receive training regarding legal endorsement, reported medicinal benefits, and potential risks, making it difficult to advise patients. Guidelines and additional research are needed.It is legal to recommend cannabis, which can be obtained in states with medical cannabis programs. There are many methods of consumption, oral being the safest. Activity is primarily through Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) via cannabinoid receptors, which may be potentiated when taken together in the plant or plant extract. The known effects of cannabis on inflammation and malignancy are largely limited to laboratory experiments. However, there are higher-quality data to support adjunctive use of cannabis for relief of pain, nausea, and insomnia, which may be useful postoperatively and could potentially decrease reliance on opiates and benzodiazepines. There are prospective trials in surgical patients, but no reported data regarding surgical complications or other surgical outcomes. Currently, cannabis is regulated differently than other controlled substances, and there are issues with purity/homogeneity, making it difficult for surgeons to accept or significantly explore its medical benefits.Recommendations are made for surgeons advising patients who use cannabis based on the limited existing data. While cannabis likely has some therapeutic benefits, it must be treated as other medical controlled substances to truly elucidate its role in surgical patient care.
Tumor-Infiltrating Natural Killer Cells
Authors: Beatriz Cózar, Marco Greppi, Sabrina Carpentier, Emilie Narni-Mancinelli, Laura Chiossone, Eric Vivier
Journal: Cancer Discovery (2020)

Abstract Because of their potent antitumor activity and their proinflammatory role, natural killer (NK) cells are at the forefront of efforts to develop immuno-oncologic treatments. NK cells participate in immune responses to tumors by killing target cells and producing cytokines. However, in the immunosuppressive tumor microenvironment, NK cells become dysfunctional through exposure to inhibitory molecules produced by cancer cells, leading to tumor escape. We provide an overview of what is known about NK tumor infiltration and surveillance and about the mechanisms by which NK cells become dysfunctional. Significance: The functions of tumor-infiltrating NK cells may be impaired. This review aims to describe the various mechanisms by which tumors alter NK-cell functions.
CMR Mapping Techniques for Myocardium at Risk: Next Step Into a Bright Future?⁎⁎Editorials published in JACC: Cardiovascular Imaging reflect the views of the authors and do not necessarily represent the views of JACC: Cardiovascular Imaging or the American College of Cardiology.
Authors: Ingo Eitel, Holger Thiele
Journal: JACC. Cardiovascular imaging (2012)
Particulate‐Based Single‐Dose Local Immunosuppressive Regimen for Inducing Tolerogenic Dendritic Cells in Xenogeneic Islet Transplantation
Authors: Shiva Pathak, Suman Acharya, Shobha Regmi, Prakash Shrestha, Zhiwei You, Young Kyung Bae, Min Hui Park, Simmyung Yook, Jae‐Ryong Kim, So Young Park, Daewon Jeong, Chul Soon Yong, Jong Oh Kim, Jae Hoon Chang, Jee‐Heon Jeong
Journal: Advanced Healthcare Materials (2020)

Abstract Recent studies emphasize on developing immune tolerance by an interim administration of various immunosuppressive drugs. In this study, a robust protocol is reported for local immunomodulation using a single‐dose of FK506 microspheres and clodronate liposomes (mFK+CLO) in a xenogeneic model of islet transplantation. Surprisingly, the single‐dose treatment with mFK+CLO induce tolerance to the islet xenograft. The recipient mice display tolerogenic dendritic cells (tDCs) with decreased antigen presenting ability and T cell activation capacity. Furthermore, a reduced percentage of CD4 + and CD8 + T cells and an impaired differentiation of naïve CD4 + T cells into interferon‐ γ producing Th1 and interleukin‐17 producing Th17 cells are observed. In addition, the immunosuppressive protocol leads to the generation of Foxp3 + regulatory T cells (Tregs) which are required for the long‐term graft survival. The enhanced generation of tDCs and Tregs by the single treatment of mFK+CLO cause xenograft tolerance, suggesting a possible clinical strategy which may pave the way towards improving therapeutic outcomes of clinical islet transplantation.
Psychological Distress and COVID-19–Related Stressors Reported in a Longitudinal Cohort of US Adults in April and July 2020
Authors: Emma E. McGinty, Rachel Presskreischer, Kelly E. Anderson, Hahrie Han, Colleen L. Barry
Journal: JAMA (2020)

Serious psychological distress was reported by 13.6% of US adults in April 2020 vs 3.9% in 2018. 1 How psychological distress has changed over the course of the coronavirus disease 2019 (COVID-19) pandemic is unknown.Methods | We fielded wave 2 of the Johns Hopkins COVID-19 Civic Life and Public Health Survey from July 7 to July 22, 2020, among US adults aged 18 years and older who responded to wave 1, fielded April 7 to April 13, 2020.The sample was drawn from NORC's AmeriSpeak panel of approximately 35 000 members sourced from NORC's area probability sample and from a US Postal Service addressbased sample covering 97% of US households. 2 AmeriSpeak's panel recruitment rate is 34%.The survey was administered online.The Johns Hopkins Bloomberg School of Public Health institutional review board deemed this study exempt and waived informed consent.We measured psychological distress in the past 30 days using the Kessler 6 scale.A score of 13 or more on the 0-to 24point scale indicated the validated measure of serious distress. 3 We then asked, "During the past 30 days, have any of the following negatively impacted your mental health?"Respondents selected from a list of potential stressors affecting them or their family members, including concern about contracting COVID-19 or experiencing adverse effects related to COVID-19 on employment, finances, education, health insurance, and ability to obtain health care or childcare.We compared prevalence of serious psychological distress overall and among demographic subgroups in July vs April, using the McNemar test to test for significant differences, defined as a 2-sided P < .05.We calculated the proportion of adults who reported serious distress in both April and July.χ 2 Tests were used to compare the prevalence of each stressor among those with vs without serious distress.Analyses were conducted in Stata version 15 (StataCorp) and incorporated survey sampling weights to generate nationally representative estimates.
15112 Epidemiology of atopic dermatitis in children aged 6-11 years: A cross-sectional Study in the United States, Canada, Europe, and Japan
Authors: Jonathan I. Silverberg, Abhijit Gadkari, Eric L. Simpson, Stephan Weidinger, Paola Mina-Osorio, Lysel Brignoli Kantar, Grèce Saba, Miriam C. Fenton, Laurent Eckert
Journal: Journal of the American Academy of Dermatology (2020)
14190 Treatment with secukinumab of severe plaque psoriasis in pediatric patients: Study design and baseline characteristics of a double-blind study
Authors: Andrzej Kaszuba, Philemon Papanastasiou, Deborah Keefe, Manmath Patekar, Lixin Zhang, Linda Ann Wraith, Dr. A Tsianakas
Journal: Journal of the American Academy of Dermatology (2020)
Recent advances in nanomedicines for the treatment of ischemic stroke
Authors: Chao Li, Tao Sun, Chen Jiang
Journal: Acta Pharmaceutica Sinica B (2020)

Ischemic stroke is a cerebrovascular disease normally caused by interrupted blood supply to the brain. Ischemia would initiate the cascade reaction consisted of multiple biochemical events in the damaged areas of the brain, where the ischemic cascade eventually leads to cell death and brain infarction. Extensive researches focusing on different stages of the cascade reaction have been conducted with the aim of curing ischemic stroke. However, traditional treatment methods based on antithrombotic therapy and neuroprotective therapy are greatly limited for their poor safety and treatment efficacy. Nanomedicine provides new possibilities for treating stroke as they could improve the pharmacokinetic behavior of drugs in vivo, achieve effective drug accumulation at the target site, enhance the therapeutic effect and meanwhile reduce the side effect. In this review, we comprehensively describe the pathophysiology of stroke, traditional treatment strategies and emerging nanomedicines, summarize the barriers and methods for transporting nanomedicine to the lesions, and illustrate the latest progress of nanomedicine in treating ischemic stroke, with a view to providing a new feasible path for the treatment of cerebral ischemia.
14234 Skin cancer and dermoscopy training for primary care physicians in Colombia: Effect on skin cancer diagnosis
Authors: Natalie M. Williams, Ana M. Muñoz, Ana M. Londoño, Manuela Munera, Nataly Naranjo, LinaM. Rodriguez, AlejandraM. Toro, Tulay Koru-Sengul, Natalia Jaimes, None MD
Journal: Journal of the American Academy of Dermatology (2020)
カンジダ血症を伴う患者の臨床転帰に及ぼす後と逆説的効果の影響の可能性の評価【Powered by NICT】
Authors: C Rueda, M Puig-Asensio, J Guinea, B Almirante, M Cuenca-Estrella, O Zaragoza
Journal: Clinical Microbiology and Infection (2017)
Bio-inspired intestinal scavenger from microfluidic electrospray for detoxifying lipopolysaccharide
Authors: Cheng Zhao, Guopu Chen, Huan Wang, Yuanjin Zhao, Renjie Chai
Journal: Bioactive Materials (2020)

Lipopolysaccharide (LPS) plays an important role in metabolic syndrome (MetS) and other gut-derived diseases, and detoxifying LPS is considered to be a fundamental approach to prevent and treat these diseases. Here, inspired by the feeding behaviour of scavenger, novel microfluidic microcapsules with alkaline phosphatase (ALP) encapsulation and the scavenger-like molecular sieve shell are presented for cleaning intestinal LPS. Benefiting from the precisely controlled of the pore size and microfluidic electrospray, the generated microcapsules were imparted with porous molecular-sieve shells and ALP encapsulated active cores. These microcapsules could continuously work as an intestinal scavenger after colonized in intestine. It has been demonstrated that the microcapsules could englobe LPS while inhibit the permeation of digestive enzyme, and this ability contributes to promising ALP's activity, protecting cells at the presence of LPS and reducing inflammation. In addition, this scavenger inspired microcapsule could effectively decrease the LPS in organs, reduce inflammation and regulating fat metabolism
マウスおよびヒトはい中心におけるCCR6は記憶B細胞前駆体,光帯を明らかにする位置と主要な低抗原親和性【Powered by NICT】
Authors: Suan Dan, J Kraeutler Nike, L V Maag Jesper, Butt Danyal, Bourne Katherine, R Hermes Jana, T Avery Danielle, Young Clara, Statham Aaron, Elliott Michael, E Dinger Marcel, Basten Antony, G Tangye Stuart, Brink Robert
Journal: Immunity (2017)
13771 Comparison of ixekizumab and adalimumab in the treatment of nail psoriasis in psoriatic arthritis patients with moderate to severe psoriasis: 24-week results from a multicenter, randomized, open-label, rater-blinded study (SPIRIT-H2H)
Authors: Saxon D. Smith, Lars Erik Kristensen, Christopher Schusters, Christophe Sapin, Soyi Liu Leage, Elisabeth Riedl, Kristian Reich, Phoebe Rich
Journal: Journal of the American Academy of Dermatology (2020)