tbuckley/cabot-search huggingface dataset:
Applicability of the Chronic Liver Failure-Consortium score in patients with cirrhosis and bacterial infections: a single-clinic experience
Authors: D.I. Haurylenka, N.N. Silivontchik
Journal: GASTROENTEROLOGY (2021)

Background. The frequency and characteristics of acute-on-chronic liver failure (ACLF) are reported in numerous articles from different countries. The aim of the study was to assess the cirrhosis decompensation in patients with bacterial infections based on the Chronic Liver Failure-Consortium (CLIF-C) score in one of the city clinics in Belarus. Materials and methods. The patients underwent laboratory and instrumental studies during the hospitalization. The assessment of the syndrome of acute-on-chronic liver failure was performed using the CLIF-C score. Bacterial infections were diagnosed on the basis of standard criteria. Results. The study included 151 cirrhotic patients, 87 males and 64 females. Median age was 55 years (Q1=43; Q3=61). Cirrhosis was predominantly due to alcohol addiction— 83 patients (55%). ACLF was diagnosed in 44 of 151 patients with cirrhosis (29.1%; 95% confidence interval (CI) 22.0–37.1). Bacterial infections were detected in 67 people (44.4%; 95% CI 36.3–52.7). Most often patients had liver failure that was detected by an increase in serum bilirubin level. Among individuals with upper gastrointestinal bleedings, number needed to harm for developing ACLF was 3.3 (95% CI 2.2–4.4). The risk of developing ACLF grade 2 and 3 in cirrhotic patients with infections was 8.2, with 95% CI 1.0–69.6 (number needed to harm was 12.9; 95% CI 10.7–15.0). Bacterial infections increase the risk of acute decompensation in patients with cirrhosis (odds ratio=2.0, p=0.048). Conclusions. The CLIF-C score is quite applicable in our cohort of patients with cirrhosis.
Description of Surgical Technique and Oncologic and Functional Outcomes of the Precision Prostatectomy Procedure (IDEAL Stage 1–2b Study)
Authors: Akshay Sood, Wooju Jeong, Isaac Palma-Zamora, Firas Abdollah, Mohit Butaney, Nicholas Corsi, Hallie Wurst, Sohrab Arora, Naveen Kachroo, Oudai Hassan, Nilesh Gupta, Michael A. Gorin, Mani Menon
Journal: European Urology (2021)
Association of Incarceration With Mortality by Race From a National Longitudinal Cohort Study
Authors: Benjamin J. Bovell-Ammon, Ziming Xuan, Michael K. Paasche-Orlow, Marc R. LaRochelle
Journal: JAMA Network Open (2021)

The association between incarceration and long-term mortality risk is unknown and may contribute to racial disparities in overall life expectancy.
空气污染会导致皮肤颜色变深
Journal: British Journal of Dermatology (2021)

一些动物种类, 包括鸽子、飞蛾和海蛇, 在暴露于城市或工业污染时, 皮肤颜色会变深。这可能是一种保护机制: 黑色素 (让人的皮肤、头发和眼睛呈现颜色的色素) 可以结合环境中毒素, 并通过正常的皮肤脱落进行将其排出。在这项研究中, 部分资金来自营销护肤品的公司, 德国的研究人员在人类皮肤中开展了研究。作者同时开展了“离体”和“体内”实验。在离体研究中, 组织取自活体生物 (在本研究中, 取自手术患者) , 然后在实验室中进行研究。与此相对, 在体内研究中, 实验在活体生物中进行, 在本研究中是健康志愿者。
Constituents of fine particulate matter and asthma in 6 low- and middle-income countries
Authors: Xiaojie Wang, Yanfei Guo, Miao Cai, Zhengmin (Min) Qian, Shiyu Zhang, Zilong Zhang, Yin Yang, Michael G. Vaughn, Hannah E. Aaron, Fan Wu, Yuqiang Zhang, Hualiang Lin
Journal: Journal of Allergy and Clinical Immunology (2021)
Successful mucosal closure of artificial gastric ulcer with twin grasping forceps and endoclips after endoscopic submucosal dissection
Authors: Michiko Nakaoka, Hideyuki Chiba, Keiji Yamada, Naoya Okada, Jun Arimoto, Hiroki Kuwabara, Toru Goto
Journal: Endoscopy (2021)

The risk of postoperative adverse events following endoscopic resection can be reduced through endoscopic closure of the artificial gastric ulcer [1], but it is not easy owing to the gastric wall thickness and hardness. There are several methods for closing ulcers induced by gastric endoscopic submucosal dissection (ESD) [2] [3] [4] [5]. Here, we describe the successful simple closure of a post-gastric ESD artificial ulcer using twin grasping forceps (Twin Grasper; Ovesco Endoscopy AG, Tubingen, Germany) and endoclips (EZ clip; Olympus, Tokyo, Japan).
miR-140-3p enhanced the osteo/odontogenic differentiation of DPSCs via inhibiting KMT5B under hypoxia condition
Authors: Han Zheng, Ning Wang, Le Li, Lihua Ge, Haichao Jia, Zhipeng Fan
Journal: International Journal of Oral Science (2021)

Human dental pulp stem cells (DPSCs) have emerged as an important source of stem cells in the tissue engineering, and hypoxia will change various innate characteristics of DPSCs and then affect dental tissue regeneration. Nevertheless, little is known about the complicated molecular mechanisms. In this study, we aimed to investigate the influence and mechanism of miR-140-3p on DPSCs under hypoxia condition. Hypoxia was induced in DPSCs by Cobalt chloride (CoCl2) treatment. The osteo/dentinogenic differentiation capacity of DPSCs was assessed by alkaline phosphatase (ALP) activity, Alizarin Red S staining and main osteo/dentinogenic markers. A luciferase reporter gene assay was performed to verify the downstream target gene of miR-140-3p. This research exhibited that miR-140-3p promoted osteo/dentinogenic differentiation of DPSCs under normoxia environment. Furthermore, miR-140-3p rescued the CoCl2-induced decreased osteo/odontogenic differentiation potentials in DPSCs. Besides, we investigated that miR-140-3p directly targeted lysine methyltransferase 5B (KMT5B). Surprisingly, we found inhibition of KMT5B obviously enhanced osteo/dentinogenic differentiation of DPSCs both under normoxia and hypoxia conditions. In conclusion, our study revealed the role and mechanism of miR-140-3p for regulating osteo/dentinogenic differentiation of DPSCs under hypoxia, and discovered that miR-140-3p and KMT5B might be important targets for DPSC-mediated tooth or bone tissue regeneration.
Overdiagnosis of hepatocellular carcinoma: Prevented by guidelines?
Authors: Nicole E. Rich, Amit G. Singal
Journal: Hepatology (2021)

Abstract Overdiagnosis refers to detection of disease that would not otherwise become clinically apparent during a patient’s lifetime. Overdiagnosis is common and has been reported for several cancer types, although there are few studies describing its prevalence in HCC surveillance programs. Overdiagnosis can have serious negative consequences including overtreatment and associated complications, financial toxicity, and psychological harms related to being labeled with a cancer diagnosis. Overdiagnosis can occur for several different reasons including inaccurate diagnostic criteria, detection of premalignant or very early malignant lesions, detection of indolent tumors, and competing risks of mortality. The risk of overdiagnosis is partly mitigated, albeit not eliminated, by several guideline recommendations, including definitions for the at‐risk population in whom surveillance should be performed, surveillance modalities, surveillance interval, recall procedures, and HCC diagnostic criteria. Continued research is needed to further characterize the burden and trends of overdiagnosis as well as identify strategies to reduce overdiagnosis in the future.
Bioresponsive nanotherapy for preventing dental caries by inhibiting multispecies cariogenic biofilms
Authors: Danfeng Liu, Xianbin Ma, Yaoting Ji, Rourong Chen, Shuhui Zhou, Hantao Yao, Zichen Zhang, Mengjie Ye, Zhigang Xu, Minquan Du
Journal: Bioactive Materials (2021)

Early childhood caries (ECC) is a public healthcare concern that greatly reduces the quality of life of young children. As a leading factor of ECC, cariogenic biofilms are composed of acidogenic/aciduric pathogens and extracellular polysaccharides (EPSs), creating an acidic and protected microenvironment. Antimicrobial photodynamic therapy (aPDT) is a noninvasive, painless, and efficient therapeutic approach that is suitable for treating ECC. However, due to the hyperfine structure of cariogenic biofilms, most photosensitizers (PSs) could not access and penetrate deeply in biofilms, which dramatically hamper their efficiency in the clinic. Herein, bioresponsive nanoparticle loaded with chlorin e6 (MPP-Ce6) is developed, which largely increases the penetration depth (by over 75%) and retention (by over 100%) of PS in the biofilm compared with free Ce6. Furthermore, MPP-Ce6-mediated aPDT not only kills the bacteria in preformed biofilms but also inhibits multispecies biofilm formation. A rampant caries model is established to mimic ECC in vivo, where the population of cariogenic bacteria is decreased to 10% after MPP-Ce6-mediated aPDT. Importantly, the number and severity of carious lesions are efficiently reduced via Keyes' scoring and micro-CT analysis. This simple but effective strategy can serve as a promising approach for daily oral hygiene in preventing ECC.
Abstract 11243: Novel Peptide for Cardiopulmonary Resuscitation
Authors: Jing Li, Xiangdong Zhu, Matt Oberdier, Chunpei Lee, Misha Granado, Sarah Fink, Shaoxia Lin, Kevin Qin, CODY JUSTICE, Hajwa Kim, Frederick Damen, Kejia Cai, Pratik B Doshi, Henry Wang, Henry R Halperin, Terry L Vanden Hoek
Journal: Circulation (2021)

Introduction: While effective for out-of-hospital cardiac arrest, therapeutic hypothermia can be difficult to timely implement clinically. No drugs exist for improving neurologically intact survival. We have developed a novel peptide (TAT-PHLPP) that inhibits PH domain and Leucine rich repeat Protein Phosphatases (PHLPP), leading to Akt activation and mimicking of the protective effects of therapeutic hypothermia without the need of physical cooling. Hypothesis: We hypothesize that when administered intravenously during CPR, TAT-PHLPP improves neurologically intact survival. Methods: We conducted parallel studies in mouse and swine models. In C57BL6 mice (n = 72), we induced a 8 or 12-min asystolic cardiac arrest with KCl, followed by initiation of CPR and blinded randomized administration of TAT-PHLPP (7.5 mg/kg) or saline placebo. The primary outcomes were 4-h and 5-day survival, mean arterial blood pressure (MAP) and cerebral blood flow (CBF). We assessed PHLPP-NHERF1 binding and glucose utilization (via pyruvate dehydrogenase (PDH) phosphorylation and ATP generation). In 16 swine, we induced 5 min of VF followed by ACLS with vest CPR and administered two doses of TAT-PHLPP or saline. Survival (24 h) and neurological function were assessed. Plasma biomarkers taurine and glutamate levels in mice were measured and validated in CA patients (n=68) with a shockable rhythm at the time of hospital arrival, 6, 24, 48, and 72 h post-hospital arrival. Results: In mice, compared to saline, TAT-PHLPP significantly improved 4-h and 5-day survival, increased post-ROSC MAP and CBF, inhibited PHLPP-NHERF1 binding, increased p-Akt, decreased p-PDH (increased activity) at 15 min post-ROSC, enhanced ATP generation in both heart and brain, and reduced plasma taurine and glutamate levels. In swine, TAT-PHLPP improved 24 h neurologically intact survival (1/9 in control vs. 6/7 with peptide, p &lt; 0.01). In patients, taurine levels were higher in non-survivors (n=44) than survivors (n=24) at 6 h of post-hospital arrival (65.9 ± 34.8 vs. 45.6 ±23.7, p&lt; 0.001). Conclusions: TAT-PHLPP has high translational potential as a first-of-class biologic treatment to reproduce critical outcomes of therapeutic hypothermia and improve cardiac arrest survival.
Abstract 12216: Association Between CPR Confidence With Anxiety in Out of Hospital Cardiac Arrest Survivors
Authors: Joseph Rojo, Clifton W CALLAWAY, Ankur A Doshi
Journal: Circulation (2021)

Introduction: There is a lack of data about specific interventions or resources that might reduce anxiety and depression in OHCA survivors. One possible factor contributing to anxiety or depression might be worry by the survivor or their family members about performing CPR or responding to a future cardiac arrest. Hypothesis: We hypothesize that there is an association of confidence about performing CPR with anxiety and depression during recovery after cardiac arrest. Methods: We enrolled subjects who were discharged home from the hospital after cardiac arrest and provided them with self-paced CPR training kits. Subjects reported Generalized Anxiety Disorder 7-item scale (GAD7), Hospital Anxiety and Depression Scale (HADS-A), and CPR knowledge and comfort scores before discharge and at 6 months. Subjects reported use of the training kit. We tested for associations between variables using chi-square and compared follow up scores using Wilcoxon signed-rank test. Results: We enrolled 95 subjects (65 male, majority in the age range of 56-65), all of whom completed the initial surveys. 19 patients met criteria for anxiety via GAD7 (=&gt;10), 23 via HADS-A (=&gt;8). Of subjects who were not comfortable performing CPR, 16/60 (27%) met GAD7 criteria compared to 3/32 (9%) who were comfortable (p=0.03).Of those not comfortable performing CPR 20/60 (33%) met HADS-A criteria compared to 3/35 (9%) who were comfortable (p=0.007).. At 6 months post discharge, 25 subjects completed follow up surveys (16 male, majority in the 56-65 age range). 12/25 (48%) used the CPR training kit; 6 met criteria for anxiety via GAD7, 9 via HADS-A. Of subjects who used the CPR kits, 1/12 (8%) met GAD7 criteria compared to those who did not use the CPR kits 5/13 (38%). Of those who used the CPR kits 3/12 (25%) met HADS-A criteria compared to those who did not use the kits 6/13 (46%), these findings however were not statistically significant (p=0.07,0.27) Additionally, those who used the CPR training kits relative to those who did not use kits had a decrease in GAD7 scores (-1.83 vs +1.84) at 6 months. Conclusion: Anxiety scores were associated with confidence about performing CPR before being discharged and using the CPR kits was associated with an improvement in anxiety scores.
Response to: Correspondence on "G-CSF as a suitable alternative to GM-CSF to boost dinutuximab-mediated neutrophil cytotoxicity in neuroblastoma treatment" by Mora<i>et al</i>
Authors: Paula Martinez Sanz, Dieke J van Rees, Hanke L Matlung, Godelieve A M Tytgat, Katka Franke
Journal: Journal for ImmunoTherapy of Cancer (2021)

Dear Editor, We appreciate the interest of Dr Mora and Dr Chantada[1][1] in our recently published work proposing granulocyte colony-stimulating factor (G-CSF) as a suitable alternative to improve antibody treatment of patients with high-risk neuroblastoma.[2][2] The authors strongly advocate
Vimentin and cytokeratin: Good alone, bad together
Authors: Nick A. Kuburich, Petra den Hollander, Jordan T. Pietz, Sendurai A. Mani
Journal: Seminars in Cancer Biology (2021)

The cytoskeleton plays an integral role in maintaining the integrity of epithelial cells. Epithelial cells primarily employ cytokeratin in their cytoskeleton, whereas mesenchymal cells use vimentin. During the epithelial-mesenchymal transition (EMT), cytokeratin-positive epithelial cells begin to express vimentin. EMT induces stem cell properties and drives metastasis, chemoresistance, and tumor relapse. Most studies of the functions of cytokeratin and vimentin have relied on the use of either epithelial or mesenchymal cell types. However, it is important to understand how these two cytoskeleton intermediate filaments function when co-expressed in cells undergoing EMT. Here, we discuss the individual and shared functions of cytokeratin and vimentin that coalesce during EMT and how alterations in intermediate filament expression influence carcinoma progression.
Impressions and aspirations from the FDA GREAT VI Workshop on Eosinophilic Gastrointestinal Disorders Beyond Eosinophilic Esophagitis and Perspectives for Progress in the Field
Authors: Marc E. Rothenberg, Shawna K.B. Hottinger, Nirmala Gonsalves, Glenn T. Furuta, Margaret H. Collins, Nicholas J. Talley, Kathryn Peterson, Calies Menard-Katcher, Macie Smith, Ikuo Hirano, Robert M. Genta, Mirna Chehade, Sandeep K. Gupta, Jonathan M. Spergel, Seema S. Aceves, Evan S. Dellon
Journal: Journal of Allergy and Clinical Immunology (2021)
The SEQC2 epigenomics quality control (EpiQC) study
Authors: Jonathan Foox, Jessica Nordlund, Claudia Lalancette, Ting Gong, Michelle Lacey, Samantha Lent, Bradley W. Langhorst, V. K. Chaithanya Ponnaluri, Louise Williams, Karthik Ramaswamy Padmanabhan, Raymond Cavalcante, Anders Lundmark, Daniel Butler, Christopher Mozsary, Justin Gurvitch, John M. Greally, Masako Suzuki, Mark Menor, Masaki Nasu, Alicia Alonso, Caroline Sheridan, Andreas Scherer, Stephen Bruinsma, Gosia Golda, Agata Muszynska, Paweł P. Łabaj, Matthew A. Campbell, Frank Wos, Amanda Raine, Ulrika Liljedahl, Tomas Axelsson, Charles Wang, Zhong Chen, Zhaowei Yang, Jing Li, Xiaopeng Yang, Hongwei Wang, Ari Melnick, Shang Guo, Alexander Blume, Vedran Franke, Inmaculada Ibanez de Caceres, Carlos Rodriguez-Antolin, Rocio Rosas, Justin Wade Davis, Jennifer Ishii, Dalila B. Megherbi, Wenming Xiao, Will Liao, Joshua Xu, Huixiao Hong, Baitang Ning, Weida Tong, Altuna Akalin, Yunliang Wang, Youping Deng, Christopher E. Mason
Journal: Genome biology (2021)

Cytosine modifications in DNA such as 5-methylcytosine (5mC) underlie a broad range of developmental processes, maintain cellular lineage specification, and can define or stratify types of cancer and other diseases. However, the wide variety of approaches available to interrogate these modifications has created a need for harmonized materials, methods, and rigorous benchmarking to improve genome-wide methylome sequencing applications in clinical and basic research. Here, we present a multi-platform assessment and cross-validated resource for epigenetics research from the FDA's Epigenomics Quality Control Group.
Fluorinated Ionic Liquid Based Multicolor <sup>19</sup>F MRI Nanoprobes for In Vivo Sensing of Multiple Biological Targets
Authors: Xianglong Zhu, Hehe Xiong, Sitian Wang, Yanyan Li, Jingxian Chi, Xuefei Wang, Tiantian Li, Qiuju Zhou, Jinhao Gao, Saige Shi
Journal: Advanced Healthcare Materials (2021)

Abstract Multicolor imaging, which maps the distribution of different targets, is important for in vivo molecular imaging and clinical diagnosis. Fluorine 19 magnetic resonance imaging ( 19 F MRI) is a promising technique because of unique insights without endogenous background or tissue penetration limit. Thus multicolor 19 F MRI probes, which can sense a wide variety of molecular species, are expected to help elucidate the biomolecular networks in complex biological systems. Here, a versatile model of activatable probes based on fluorinated ionic liquids (ILs) for multicolor 19 F MRI is reported. Three types of ILs at different chemical shifts are loaded in nanocarriers and sealed by three stimuli‐sensitive copolymers, leading to “off” 19 F signals. The coating polymers specifically respond to their environmental stimuli, then degrade to release the loaded ILs, causing 19 F signals recovery. The nanoprobes are utilized for non‐invasive detection of tumor hallmarks, which are distinguished by their individual colors in one living mouse, without interference between each other. This multicolor imaging strategy, which adopts modular construction of various ILs and stimuli‐responsive polymers, will allow more comprehensive sensing of multiple biological targets, thus, opening a new realm in mechanistic understanding of complex pathophysiologic processes in vivo.
Asbestos Wasn’t Found in Cosmetics Containing Talc
Authors: Rebecca Voelker
Journal: JAMA (2021)

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63P Shifting treatment landscape and overall survival (OS) by PD-L1 expression level among patients (pts) with advanced non-small cell lung cancer (aNSCLC)
Authors: H. Dietz, N. Wu, W. Ge, R.G. Quek, J-F. Pouliot, S.J. Antonia, J. Jalbert, J. Harnett
Journal: Annals of Oncology (2021)
Activation of YAP1 by N6-Methyladenosine–Modified circCPSF6 Drives Malignancy in Hepatocellular Carcinoma
Authors: Yunhao Chen, Zhenan Ling, Xianlei Cai, Yongfang Xu, Zhen Lv, Da Man, Jiangzhen Ge, Chengkuan Yu, Deguo Zhang, Yanpeng Zhang, Haiyang Xie, Lin Zhou, Jian Wu, Shusen Zheng
Journal: Cancer Research (2021)

Circular RNAs (circRNA) and N6-methyladenosine (m6A) modification are extensively involved in the progression of diverse tumors, including hepatocellular carcinoma (HCC). However, the cross-talk between circRNAs and m6A remains elusive in the pathogenesis of HCC. Here we investigated m6A-mediated regulation of circRNAs in HCC. m6A-related circRNAs were identified by integrating information from two published studies, revealing circular cleavage and polyadenylation specific factor 6 (circCPSF6) as a novel m6A-modified circRNA. circCPSF6 was dominated by ALKBH5-mediated demethylation, followed by the recognization and destabilization by YTHDF2. Meanwhile, circCPSF6 was upregulated in HCC specimens, and elevated circCPSF6 expression served as an independent prognostic factor for worse survival of patients with HCC. Loss-of-function assays demonstrated that circCPSF6 maintained cell proliferation and tumorigenicity and reinforced cell motility and tumor metastasis. circCPSF6 triggered expression of YAP1, further activating its downstream cascade. Mechanistically, circCPSF6 competitively bound PCBP2, blunting its binding to YAP1 mRNA, thereby sustaining the stability of YAP1. Functionally, removal of YAP1 reversed the effects of circCPSF6 in vitro and in vivo. Aberrant activation of the circCPSF6-YAP1 axis promoted HCC malignancy. These findings offer novel insights into the regulation of circRNAs by m6A modifications and the role of this epigenetic reprogramming in HCC.This study advances the understanding of the interplay between m6A methylation and circRNAs in hepatocellular carcinoma, highlighting the potential of circCPSF6 as a therapeutic target.