tbuckley/cabot-search huggingface dataset:
TCT-314 The Risk-Treatment Paradox in Acute Coronary Syndrome Patients: Insights From The FORCE-ACS Registry
Authors: Jaouad Azzahhafi, Niels van der Sangen, Dean Chan Pin Yin, Senna Rayhi, Jose Henriques, Wouter Kikkert, Jurrien Ten Berg
Journal: Journal of the American College of Cardiology (2021)
TCT-466 Procedural Success and Clinical Outcomes of Chronic Total Occlusion Percutaneous Coronary Intervention in Patients With Prior Coronary Artery Bypass Graft Surgery: Insights From the LATAM CTO Registry
Authors: Dagmar Hernandez-Suarez, Lorenzo Azzalini, Francesco Moroni, Alexandre Quadros, Pablo Lamelas, Carlos Campos, Marcelo Harada, Evandro Martins Filho, Felix Damas de los Santos, Joao Tinoco, Marco Alcantara, Lucio Padilla, Mauro Echavarria Pinto, Marcia Schmidt, Israel Almodovar-Rivera, Ricardo Santiago
Journal: Journal of the American College of Cardiology (2021)
A genome variation map provides insights into the genetics of walnut adaptation and agronomic traits
Authors: Feiyang Ji, Qingguo Ma, Wenting Zhang, Jie Liu, Yu Feng, Peng Zhao, Xiaobo Song, Jiaxin Chen, Junpei Zhang, Xin Wei, Ye Zhou, Yingying Chang, Pu Zhang, Xuehui Huang, Jie Qiu, Dong Pei
Journal: Genome biology (2021)

Abstract Background Common walnut ( Juglans regia L.) is one of the top four most consumed nuts in the world due to its health benefits and pleasant taste. Despite its economic importance, the evolutionary history and genetic control of its adaptation and agronomic traits remain largely unexplored. Results We report a comprehensive walnut genomic variation map based on whole-genome resequencing of 815 walnut accessions. Evolutionary analyses suggest that Chinese J. regia diverged from J. sigillata with extensive hybridizations after the split of the two species. In contrast to annual crops, the genetic diversity and heterozygous deleterious mutations of Chinese common walnut trees have continued to increase during the improvement process. Selective sweep analyses identify 902 genes uniquely selected in the improved common walnut compared to its progenitor population. Five major-effect loci are identified to be involved in walnut adaptations to temperature, precipitation, and altitude. Genome-wide association studies reveal 27 genomic loci responsible for 18 important agronomic traits, among which JrFAD2 and JrANR are the potentially major-effect causative genes controlling linoleic acid content and color of the endopleura of the nut, respectively. Conclusions The largest genomic resource for walnuts to date has been generated and explored in this study, unveiling their evolutionary history and cracking the genetic code for agronomic traits and environmental adaptation of this economically crucial crop tree.
TCT-223 The Coronary CT–Derived Plaque Burden and Low-Attenuation Plaque According to Fractional Flow Reserve Range in Diabetic Patients With Deferred Vessels and Its Prognostic Implication
Authors: Kyu-Sun Lee, Bon-Kwon Koo, Seokhun Yang, Doyeon Hwang, Gilwoo Choi, Joo Myung Lee, Jiesuck Park, Eun-Seok Shin, Joon-Hyung Doh, Hyuk-Jae Chang
Journal: Journal of the American College of Cardiology (2021)
Loss of Y and clonal hematopoiesis in blood—two sides of the same coin?
Authors: Viktor Ljungström, Jonas Mattisson, Jonatan Halvardson, Tatjana Pandzic, Hanna Davies, Edyta Rychlicka-Buniowska, Marcus Danielsson, Paul Lacaze, Lucia Cavelier, Jan P. Dumanski, Panagiotis Baliakas, Lars A. Forsberg
Journal: Leukemia (2021)
<i>Dnmt3a</i>-mutated clonal hematopoiesis promotes osteoporosis
Authors: Peter Geon Kim, Abhishek Niroula, Veronica Shkolnik, Marie McConkey, Amy E. Lin, Mikołaj Słabicki, John P. Kemp, Alexander Bick, Christopher J. Gibson, Gabriel Griffin, Aswin Sekar, Daniel J. Brooks, Waihay J. Wong, Drew N. Cohen, Md Mesbah Uddin, Wesley J. Shin, James Pirruccello, Jonathan M. Tsai, Mridul Agrawal, Douglas P. Kiel, Mary L. Bouxsein, J. Brent Richards, David M. Evans, Marc N. Wein, Julia F. Charles, Siddhartha Jaiswal, Pradeep Natarajan, Benjamin L. Ebert
Journal: The Journal of Experimental Medicine (2021)

Osteoporosis is caused by an imbalance of osteoclasts and osteoblasts, occurring in close proximity to hematopoietic cells in the bone marrow. Recurrent somatic mutations that lead to an expanded population of mutant blood cells is termed clonal hematopoiesis of indeterminate potential (CHIP). Analyzing exome sequencing data from the UK Biobank, we found CHIP to be associated with increased incident osteoporosis diagnoses and decreased bone mineral density. In murine models, hematopoietic-specific mutations in Dnmt3a, the most commonly mutated gene in CHIP, decreased bone mass via increased osteoclastogenesis. Dnmt3a−/− demethylation opened chromatin and altered activity of inflammatory transcription factors. Bone loss was driven by proinflammatory cytokines, including Irf3-NF-κB–mediated IL-20 expression from Dnmt3a mutant macrophages. Increased osteoclastogenesis due to the Dnmt3a mutations was ameliorated by alendronate or IL-20 neutralization. These results demonstrate a novel source of osteoporosis-inducing inflammation.
Building the future medical workforce: helping students choose psychiatry
Authors: Subodh Dave
Journal: BMJ (2021)

My career in psychiatry has been incredibly interesting and fulfilling. Despite the inevitable challenges, I look forward to going to work every day knowing how much of a difference my colleagues and I can make in the lives of people with mental illnesses. At the same time, I am daunted by the unprecedented demand we are seeing on our services and the challenge of the mental health backlog. The long term impact of covid-19 on the nation’s mental health has been greater than anyone could have anticipated. Even before the pandemic, the need to bolster mental health services was recognised as an urgent priority. It has become extremely clear that to effectively respond to patients’ needs will rely on our ability to recruit and retain qualified, inspired, and passionate psychiatrists.

The Royal College of Psychiatrists …
Immunogenicity Rates After SARS-CoV-2 Vaccination in People With End-stage Kidney Disease
Authors: Jia-Jin Chen, Tao Han Lee, Ya-Chung Tian, Cheng-Chia Lee, Pei-Chun Fan, Chih-Hsiang Chang
Journal: JAMA Network Open (2021)

Adults receiving dialysis treatment have a higher likelihood of death when infected with SARS-CoV-2 than adults not receiving dialysis treatment. To date, the immune response of people receiving dialysis after SARS-CoV-2 vaccination has not been systematically discussed.To assess immunogenicity rates in people with end-stage kidney disease (ESKD) receiving SARS-CoV-2 vaccines, explore postvaccination potential risk factors for nonresponse, and assess whether receiving dialysis is associated with different antibody response rates compared with the nondialysis population.This systematic review and meta-analysis used articles from PubMed, Medline, and Embase published before July 30, 2021, as well as articles in the medRxiv preprint server.Studies that evaluated the immunogenicity rate according to the postvaccine antibody response rate in patients with ESKD receiving dialysis were selected.The meta-analysis was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. A random-effects model was used. Two independent reviewers conducted the literature search and extracted the data.The primary outcome was the pooled antibody postvaccine response rates in individuals with ESKD. The secondary outcomes were pooled response rates in individuals receiving and not receiving dialysis. Subgroup analysis and meta-regression were conducted to identify the sources of heterogeneity.A total of 32 studies were included. The overall immunogenicity rate of the dialysis group was 86% (95% CI, 81%-89%). Meta-regression showed a significant difference was detected in the postvaccine response rate on the basis of prevalence of diabetes (regression coefficient, -0.06; 95% CI, -0.10 to -0.02; P = .004). Compared with nondialysis controls, patients in the dialysis group had a lower response rate after the first (relative risk [RR], 0.61; 95% CI, 0.47-0.79; I2 = 70.2%) and second (RR, 0.88; 95% CI, 0.82-0.93; I2 = 72.2%) doses, with statistically significantly increased RR between first and second doses (P = .007).These findings suggest that the immunogenicity rate among patients receiving dialysis was 41% after the first dose and 89% after the second dose. Diabetes might be a risk factor for nonresponse in the dialysis population. Patients receiving dialysis had a poorer antibody response rate than did individuals not receiving dialysis, particularly after the first dose.
Risk Factors for AKI and Mortality in COVID-19 in Western Mexico
Authors: Alejandro Garcia Rivera, Ríos C. Katia yuritzi, Arantxa K. Aguilar, Luz Yareli Villegas Gutierrez, Marcos A. Elias Lopez, Jesús A. Rico sánchez, Mónica L. Morales Guillén, Mauro G. Montemayor Villacobos, Roxana Villanueva Macedo, Hugo B. Espinoza, Ramon A. Soto Rodriguez, José J. Gutiérrez Hernandez, Omar H. Sanchez Vazquez, Jorge fernando Topete reyes, Renato Parra Michel, Rubén Lara Monterrubio, Mario Valdez Avendaño, Fabiola V. Rios Rios, Carolina R. Alvarez
Journal: Journal of the American Society of Nephrology (2021)

Rivera, Alejandro Garcia; Katia yuritzi, Ríos C.; Aguilar, Arantxa K.; Gutierrez, Luz Yareli Villegas; Elias Lopez, Marcos A.; Rico sánchez, Jesús A.; Morales Guillén, Mónica L.; Montemayor Villacobos, Mauro G.; Macedo, Roxana Villanueva; Espinoza, Hugo B.; Soto Rodriguez, Ramon A.; Gutiérrez Hernandez, José J.; Sanchez Vazquez, Omar H.; Topete reyes, Jorge fernando; Michel, Renato Parra; Monterrubio, Rubén Lara; Avendaño, Mario Valdez; Rios Rios, Fabiola V.; Alvarez, Carolina R. Author Information
National Surveillance for Acute Flaccid Myelitis — United States, 2018–2020
Authors: Sarah Kidd, Eileen Yee, Randall English, Shannon Rogers, Brian Emery, Halle Getachew, Janell A. Routh, Adriana S. Lopez
Journal: MMWR Morbidity and Mortality Weekly Report (2021)

Acute flaccid myelitis (AFM), a recognized complication of certain viral infections, is a serious neurologic condition that predominantly affects previously healthy children and can progress rapidly, leading to respiratory insufficiency and permanent paralysis. After national AFM surveillance began in 2014, peaks in AFM cases were observed in the United States in 2014, 2016, and 2018 (1). On the basis of this biennial pattern, an increase in AFM was anticipated in 2020. To describe the epidemiology of confirmed AFM cases since 2018, demographic, clinical, and laboratory information collected as part of national AFM surveillance was reviewed. In 2018, a total of 238 confirmed AFM cases were reported to CDC, compared with 47 cases in 2019 and 32 in 2020. Enterovirus D68 (EV-D68) was detected in specimens from 37 cases reported in 2018, one case in 2019 and none in 2020. Compared with 2018, cases reported during 2019-2020 occurred in older children and were less frequently associated with upper limb involvement, febrile or respiratory prodromal illness, or cerebrospinal fluid (CSF) pleocytosis. These findings suggest that the etiologies of AFM in 2019 and 2020 differed from those in 2018. The absence of an increase in cases in 2020 reflects a deviation from the previously observed biennial pattern, and it is unclear when the next increase in AFM should be expected. Clinicians should continue to maintain vigilance and suspect AFM in any child with acute flaccid limb weakness, particularly in the setting of recent febrile or respiratory illness.
Paneth cell dysfunction and the intestinal microbiome in XIAP deficiency
Authors: Aline Azabdaftari, Holm H. Uhlig
Journal: Science Immunology (2021)

New data suggest how epithelial dysfunction and intestinal dysbiosis contribute to inflammatory bowel disease in patients and in models of XIAP deficiency (see the related Research Articles by Strigli et al. and Wahida et al.).
Chrysin serves as a novel inhibitor of DGKα/FAK interaction to suppress the malignancy of esophageal squamous cell carcinoma (ESCC)
Authors: Jie Chen, Yan Wang, Di Zhao, Lingyuan Zhang, Weimin Zhang, Jiawen Fan, Jinting Li, Qimin Zhan
Journal: Acta Pharmaceutica Sinica B (2020)

Among current novel druggable targets, protein–protein interactions (PPIs) are of considerable and growing interest. Diacylglycerol kinase α (DGKα) interacts with focal adhesion kinase (FAK) band 4.1-ezrin-radixin-moesin (FERM) domain to induce the phosphorylation of FAK Tyr397 site and promotes the malignant progression of esophageal squamous cell carcinoma (ESCC) cells. Chrysin is a multi-functional bioactive flavonoid, and possesses potential anticancer activity, whereas little is known about the anticancer activity and exact molecular mechanisms of chrysin in ESCC treatment. In this study, we found that chrysin significantly disrupted the DGKα/FAK signalosome to inhibit FAK-controlled signaling pathways and the malignant progression of ESCC cells both in vitro and in vivo, whereas produced no toxicity to the normal cells. Molecular validation specifically demonstrated that Asp435 site in the catalytic domain of DGKα contributed to chrysin-mediated inhibition of the assembly of DGKα/FAK complex. This study has illustrated DGKα/FAK complex as a target of chrysin for the first time, and provided a direction for the development of natural products-derived PPIs inhibitors in tumor treatment.
TCT-183 A Simple Point-Based Clinical Prediction Score to Predict Stroke After Left Atrial Appendage Closure: An Analysis of the National Readmissions Database
Authors: Krishna Akella, Mayank Sardana, Sunil Pathak, Rohan Trivedi, Parker Lavigne, Rahul Doshi, Adam Sabbath, Andrew Grees, Elnaz Mahbub, Garry Lachhar, Ghulam Murtaza, David Riggio, Sahran Sharma, Jamie Howard, Zoya Ahmad, Corie Rogers, Pratik Dalal, Nikhil Iyengar, Dhanunjaya Lakkireddy, Rakesh Gopinathannair, Domenico Della Rocca, Jie Chung, Juan Siordia, Lydia Taranto, Erik Dvergsten, Kevin Gosselin, Dannah Farah
Journal: Journal of the American College of Cardiology (2021)
Citius, Fortius, Altius—Understanding Which Components Drive Exercise Benefits in Parkinson Disease
Authors: Nienke M. de Vries, Sirwan K. L. Darweesh, Bastiaan R. Bloem
Journal: JAMA Neurology (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Abstract 12634: Confounding and Mediation of the Association Between Psychological Attitudes and Type 2 Diabetes Risk Among Postmenopausal Women
Authors: Meredith S Duncan, Matthew S Freiberg, Simin Liu, Lewis H Kuller, Jie Li, Aladdin Shadyab, Jaimie Hunter, Milagros C Rosal, Juhua Luo, Hilary A Tindle
Journal: Circulation (2019)

Introduction: Higher levels of pessimism and cynical hostility and lower levels of optimism are all associated with increased diabetes risk. However, only pessimism was associated with higher insul...
Abstract 11501: Supplemental Oxygen is Associated With Larger Infarct Size but Not Excess Risk of Adverse Cardiac Events in Non-st Elevation Myocardial Infarction
Authors: Omar Abu-Jaradeh, Abdullah Ahmad, Stephanie O Frisch, Ziad Faramand, Parker Landis, Ahmad Mahmoud, Clifton W Callaway, Christian Martin-Gill, Salah S Al-Zaiti
Journal: Circulation (2019)

Introduction: Oxygen has been historically used for the initial management of acute myocardial infarction (MI). A recent meta-analysis of randomized clinical trials showed that oxygen use at high-f...
The American Board of Surgery Should Reconsider Its Parental Leave Policy
Authors: Paula Marincola Smith, Mina F. Nordness, Monica E. Polcz
Journal: JAMA Surgery (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
TCT-220 Impact of Left Ventricular End-Diastolic Pressure on the Outcomes of Patients Undergoing Percutaneous Coronary Intervention
Authors: Lorenzo Azzalini, Milan Seth, Devraj Sukul, Dilip Arora, Joseph Chattahi, Abdulfatah Osman, Vishal Gupta, Giuseppe Tarantini, Mamas Mamas, Hitinder Gurm
Journal: Journal of the American College of Cardiology (2021)
TCT-215 Snorkel Stenting Versus BASILICA for Coronary Obstruction: An Analysis of the International Multicenter COBRA-TAVR Registry
Authors: John Lisko, Errol Inci, Patrick Gleason, Isida Byku, Chandan Devireddy, Gaetano Paone, Kendra Grubb, Robert Guyton, Joe Xie, Chris Bruce, Jaffar Khan, Toby Rogers, Robert Lederman, Adam Greenbaum, Vasilis Babaliaros
Journal: Journal of the American College of Cardiology (2021)
The Role of Gray-Scale Ultrasound in the Diagnosis of Postnatal Testicular Torsion in Children
Authors: E. B. Olkhova, M. V. Topolnik, A. Yu. Rudin, V. I. Runenko, I. V. Melnik
Journal: Radiology - Practice (2021)

Testicular torsion is a severe variant of postnatal gonad pathology in children. The speed of development of irreversible ischemic disorders determines not only the medical, but also the social significance of the problem and determines the need for accurate and rapid diagnosis and prompt provision of adequate care to the patient. The only objective method for diagnosing testicular torsion in children is ultrasound. At the same time, the characteristics of the child’s body: the small size of the object of study, low rates of intratesticular blood flow and restless behavior during the study sharply reduce the diagnostic value of the Doppler study or make it technically impossible. Thus, seroshkal ultrasound is the first stage of diagnosis of this complex emergency pathology, based on the results of which it is possible to diagnose testicular torsion with great accuracy. The publication summarizes our own experience of 110 echographic observations of postnatal testicular torsion in children older than 2 months, all cases were verified intraoperatively. A quantitative method for estimating the deformity of a twisted testicle is proposed and its statistical reliability is proved. The options presented for gray-scale changes in the structure of damaged gonads and determined their prognostic significance. The publication contains a review of the literature and is extensively illustrated.
Commensal Cryptosporidium colonization elicits a cDC1-dependent Th1 response that promotes intestinal homeostasis and limits other infections
Authors: Emilie V Russler-Germain, Jisun Jung, Aidan T Miller, Shannon Young, Jaeu Yi, Alec Wehmeier, Lindsey E Fox, Kristen J Monte, Jiani N Chai, Devesha H Kulkarni, Lisa J Funkhouser-Jones, Georgia Wilke, Vivek Durai, Bernd H Zinselmeyer, Rafael S Czepielewski, Suellen Greco, Kenneth M Murphy, Rodney D Newberry, L David Sibley, Chyi-Song Hsieh
Journal: Immunity (2021)
TCT-383 Transradial Versus Transfemoral Access and the Risk for Contrast-Induced Acute Kidney Injury Following Primary Percutaneous Coronary Intervention in Patients With ST-Segment Elevation Myocardial Infarction: A Meta-Analysis of Randomized Controlled Trials and Propensity Score–Matched Studies
Authors: Gaspar Del Rio-Pertuz, Poemlarp Mekraksakit, Abel Triana, Kanak Parmar, Zeyad Elharabi, Mostafa Abohelwa, Mohammad Mehdi Ansari
Journal: Journal of the American College of Cardiology (2021)
Characteristics of the Residential Environment and Their Association With Depression in Hong Kong
Authors: Chinmoy Sarkar, Ka Yan Lai, Sarika Kumari, Gabriel M. Leung, Chris Webster, Michael Y. Ni
Journal: JAMA Network Open (2021)

With rapid urbanization, understanding the role of residential environments in the development of depression has gained importance. However, the potential associations of residential space and density with depression have been understudied.To investigate longitudinal associations of residential livable space and density with depression.This longitudinal cohort study used data from 2 waves of the FAMILY Cohort, a population-based cohort in the Hong Kong Special Administrative Region, China, recruited between February 28, 2009, and March 28, 2011, at baseline and followed up between August 3, 2011, and June 19, 2013, at wave 2. Data were analyzed from September 1, 2020, through August 10, 2021. A total of 16 968 participants aged 16 years or older underwent assessment using the Patient Health Questionnaire-9 (PHQ-9) and had complete data across all variables.Residential density was objectively assessed at 3 scales (within apartment, building block, and at neighborhood level) at baseline and follow-up.Depressive symptoms were defined in terms of a PHQ-9 threshold greater than or equal to 5 and probable major depression with a cutoff value greater than or equal to 10. A continuous PHQ-9 score was used as a secondary outcome. Multilevel logistic regression models were used to examine associations of the residential density with probable major depression and depressive symptoms adjusted for time-varying sociodemographic and lifestyle factors, comorbidities, and other environment variables.Of the 16 968 participants with complete data, the mean (SD) age was 45.5 (16.7) years, and 9328 participants (55.0%) were women at baseline. The mean follow-up was 2.2 years (range, 1.3-3.6 years). At the household level, after full adjustments, each IQR increment in residential livable area was associated with lower odds of probable major depression (adjusted odds ratio [aOR], 0.84; 95% CI, 0.71-0.98; P = .03) and depressive symptoms (aOR, 0.93; 95% CI, 0.86-1.00; P = .04). At the building-block level, each IQR increment in block density was associated with higher odds of depressive symptoms (aOR, 1.11; 95% CI, 1.01-1.22; P = .03), but only in single-housing environment models. The results remained consistent in models with continuous PHQ-9 evaluation.This study's findings suggest that residential livable space and block density may play a role in the development of depression. Integrated mental health and housing policies promoting mental capital in cities, such as health-optimized density at the household and building-block levels, might serve as a population approach to reduce the burden of depression.