tbuckley/cabot-search huggingface dataset:
Abstract 1776: Peripheral Arterial Disease Determined by Screening Ankle Brachial Index Testing Predicts High Risk Findings On Stress Myocardial Perfusion SPECT Imaging
Authors: R Parker Ward, Linda A Taillon, Justin Weiner, Kim A Williams
Journal: Circulation (2007)

Background: Peripheral arterial disease (PAD) as determined by ankle brachial index (ABI) testing is a potent marker of adverse cardiovascular prognosis. Stress myocardial perfusion SPECT (MPS) testing allows diagnosis of coronary artery disease (CAD) and stratification of cardiovascular risk. The stress MPS findings in patients (pts) with occult PAD are unknown. Accordingly, our goal was to determine the prevalence high risk (HR) MPS findings in pts with occult PAD diagnosed by screening ABI who are referred for MPS testing. Methods: As part of a prospective data collection, 679 male pts referred for MPS were screened for PAD with ABI evaluation. Pts with non-diagnostic ABIs (&gt;1.3) or prior known PAD were excluded. PAD was defined as an ABI ≤ 0.9. PAD severity (mild [ABI 0.8 – 0.9], moderate [ABI 0.4 – 0.8], severe [&lt;0.4]) and symptoms of PAD were also noted. CAD was defined as mild (summed stress score (SSS) ≥ 4) or severe (SSS&gt;8), and the composite of any HR finding (SSS&gt;8, left ventricular ejection fraction [LVEF] &lt; 40%, or TID) was recorded. Results: PAD was present in 28%. Of pts found to have PAD, 65% reported no lower extremity symptoms. Compared to no PAD, pts with PAD were found to have significantly more mild or greater CAD (51% vs. 36%, p&lt;0.01), severe CAD (35% vs. 19%, p&lt;0.01), LV dysfunction [LVEF &lt; 40%] (14% vs 7%, p &lt; 0.01), and composite HR MPS findings (40% vs. 22%, p&lt;0.01). On multivariate logistic regression analysis considering age, HTN, diabetes, tobacco use, hypercholesterolemia, and prior coronary artery disease, PAD was found to be an independent predictor of mild or greater CAD (OR 1.6, 95% CI 1.1–2.4, p&lt;0.01), severe CAD (OR 1.9 95% CI 1.3–3.0, p&lt;0.01), and any HR MPS finding (OR 2.0 95% CI 1.3–3.0, p&lt;0.01). Conclusions: Among men referred for stress testing, occult PAD is common, and is an independent predictor of significant CAD and HR findings on MPS testing. Further study is needed to determine if PAD in pts without an indication for stress testing may benefit from screening MPS.
Artificial intelligence versus expert endoscopists for diagnosis of gastric cancer in patients who have undergone upper gastrointestinal endoscopy
Authors: Ryota Niikura, Tomonori Aoki, Satoki Shichijo, Atsuo Yamada, Takuya Kawahara, Yusuke Kato, Yoshihiro Hirata, Yoku Hayakawa, Nobumi Suzuki, Masanori Ochi, Toshiaki Hirasawa, Tomohiro Tada, Takashi Kawai, Kazuhiko Koike
Journal: Endoscopy (2021)

Abstract Aims To compare endoscopy gastric cancer images diagnosis rate between artificial intelligence (AI) and expert endoscopists. Patients and methods We used the retrospective data of 500 patients, including 100 with gastric cancer, matched 1:1 to diagnosis by AI or expert endoscopists. We retrospectively evaluated the noninferiority (prespecified margin 5 %) of the per-patient rate of gastric cancer diagnosis by AI and compared the per-image rate of gastric cancer diagnosis. Results Gastric cancer was diagnosed in 49 of 49 patients (100 %) in the AI group and 48 of 51 patients (94.12 %) in the expert endoscopist group (difference 5.88, 95 % confidence interval: −0.58 to 12.3). The per-image rate of gastric cancer diagnosis was higher in the AI group (99.87 %, 747 /748 images) than in the expert endoscopist group (88.17 %, 693 /786 images) (difference 11.7 %). Conclusions Noninferiority of the rate of gastric cancer diagnosis by AI was demonstrated but superiority was not demonstrated.
478P TA-ness classification discriminates RAS wild-type (wt) metastatic colorectal cancer (mCRC) patients (pts) who may benefit from antiEGFR treatment
Authors: C. Santos, P. Lawrence, A. Lopez-Doriga, C. Ragulan, E. Fontana, K. Desai, H. Ps, M.E. Elez Fernandez, E. Aranda Aguilar, F. Losa, D. Paez, L. Layos Romero, X. Sanjuan, M.A. Cañas, D. Azuara, B. Queralt, P. Fernandez-Calotti, R. Salazar, A. Sadanandam
Journal: Annals of Oncology (2021)
Frailty assessment in the care of older people with haematological malignancies
Authors: Valentin Goede, Nina Rosa Neuendorff, Ralf-Joachim Schulz, Ana-Isabel Hormigo, Francisco Javier Martinez-Peromingo, Raul Cordoba
Journal: The Lancet Healthy Longevity (2021)

Frailty, defined as an age-related state of increased vulnerability to acute stressors, is a major challenge in the care of older people with haematological malignancies. Growing evidence from multiple studies suggests that a systematic evaluation of frailty in these patients by use of appropriate assessment tools might help clinicians to make appropriate treatment decisions and initiate frailty interventions. Here, we summarise current knowledge on the origin, decision relevance, assessment methods, and possible treatments of frailty in older people with haematological malignancies. Practical advice is provided on how to care for those with frailty and blood cancer.
Cost of Drugs
Authors: M. G. Webb
Journal: JAMA (1976)

To the Editor.—  The excellent article by Dr Hollister (234:942, 1975) contains confusing statistics. It is stated that more than 1.4 billion prescriptions... are filled each year [at] costs... estimated between $500 million and $1 billion each year.... It is not stated whether these statistics are for the United States or worldwide, or whether the costs are to the pharmacist or to the patient. The assumption is that the statistics are for the United States, and that the costs are the retail costs. A rapid calculation on those assumptions indicates that an average of six to seven prescriptions are filled each year for every citizen, newborn through centenarian, at an average retail cost between 35 and 70 cents each. These results indicate a need to reexamine and clarify the data, and to correct the public record.  The problem presented by such data is that they tend to
1619P Transition to a virtual cancer multidisciplinary team meeting during the COVID-19 pandemic: Experience from a regional Irish Cancer Centre
Authors: C.M. Goggin, N. Myo Oo, M. Hennessy, M. Hamid, P. Lynch, M. O'Connor, A. Horgan, P.M. Calvert, E. Jordan, J. Greene
Journal: Annals of Oncology (2021)
The cardiovascular effects of air pollution: Prevention and reversal by pharmacological agents
Authors: Mark R. Miller
Journal: Pharmacology & Therapeutics (2021)

Air pollution is associated with staggering levels of cardiovascular morbidity and mortality. Airborne particulate matter (PM), in particular, has been associated with a wide range of detrimental cardiovascular effects, including impaired vascular function, raised blood pressure, alterations in cardiac rhythm, blood clotting disorders, coronary artery disease, and stroke. Considerable headway has been made in elucidating the biological processes underlying these associations, revealing a labyrinth of multiple interacting mechanistic pathways. Several studies have used pharmacological agents to prevent or reverse the cardiovascular effects of PM; an approach that not only has the advantages of elucidating mechanisms, but also potentially revealing therapeutic agents that could benefit individuals that are especially susceptible to the effects of air pollution. This review gathers investigations with pharmacological agents, offering insight into the biology of how PM, and other air pollutants, may cause cardiovascular morbidity.
575TiP Cabozantinib plus atezolizumab in advanced and progressive neoplasms of the endocrine system: A multicohort phase II trial (CABATEN trial / GETNE-T1914)
Authors: E. Grande, R. Garcia-Carbonero, A. Teule, M. Benavent Viñuales, P. Jimenez-Fonseca, J. Molina-Cerrillo, C. López, A. Custodio, C. Hierro, J. Gallego, V. Alonso, A. Carmona-Bayonas, M. Llanos, I. Sevilla, J. Hernando, F. Lista, B. Antón Pascual, J.C. Ruffinelli, I. Gallego Jiménez, J. Capdevila
Journal: Annals of Oncology (2021)
832MO Immune microenvironment in classical Hodgkin lymphoma: Composition and dynamics in patients with relapsed/refractory disease
Authors: L. Fedorova, A. Gusak, K. Lepik, N. Volkov, M. Popova, I. Moiseev, N. Mikhailova, V. Baykov, A. Kulagin
Journal: Annals of Oncology (2021)
AGPAT2の不在は,褐色脂肪生成を障害し,IFN刺激遺伝子発現を増加し,ミトコンドリア形態を変える【JST・京大機械翻訳】
Authors: J Tapia Pablo, Figueroa Ana-Maria, Eisner Veronica, Gonzalez-Hodar Lila, Robledo Fermin, K Agarwal Anil, Garg Abhimanyu, Cortes Victor
Journal: Metabolism (2020)
<scp>COVID</scp>‐19 vaccination in patients with heart failure: a position paper of the Heart Failure Association of the European Society of Cardiology
Authors: Giuseppe Rosano, Ewa A. Jankowska, Robin Ray, Marco Metra, Magdy Abdelhamid, Stamatis Adamopoulos, Stefan D. Anker, Antoni Bayes‐Genis, Yury Belenkov, Tuvia Ben Gal, Michael Böhm, Ovidiu Chioncel, Alain Cohen‐Solal, Dimitrios Farmakis, Gerasimos Filippatos, Arantxa González, Finn Gustafsson, Loreena Hill, Tiny Jaarsma, Fadi Jouhra, Mitja Lainscak, Ekaterini Lambrinou, Yury Lopatin, Lars H. Lund, Davor Milicic, Brenda Moura, Wilfried Mullens, Massimo F. Piepoli, Piotr Ponikowski, Amina Rakisheva, Arsen Ristic, Gianluigi Savarese, Petar Seferovic, Michele Senni, Thomas Thum, Carlo G. Tocchetti, Sophie Van Linthout, Maurizio Volterrani, Andrew J.S. Coats
Journal: European Journal of Heart Failure (2021)
Medical student engagement with surgery and research during the COVID-19 pandemic: Supporting the future workforce for post-pandemic surgical recovery
Authors: Shiraz Q. Shafi, Samuel Brown, Rachel A. Khaw, Johnathan Hirniak, Joshua R. Burke, Lola Giwa, Lorna Marson, Arnold Hill, Dileep Lobo, James C. Glasbey, Kenneth A. McLean, T. Patel, G. Liu, A. Singal, R. Nam, A. Kathiravelupillai, W. L. Chia, S. Z.Y. Ooi, M. Matthews, Subbiah H. Ponniah, J. Komor, A. Heyes, S. Tushingham, D. S. Hettiarachchi, T K, S. Gaier, C. Jordan, A. Joyce, E. Johnston, K. Valentine, K. Nagassima, Rodrigues dos Reis, M. O’Sullivan, A. Tittawella, E. Geary, C. Thorpe, A. H.B. Jalal, M. Georgi, A. Mergo, E. Ramsay, J. Sheikh, A. Ashok, K. S. Lee, R. Risquet, S. Kathiravelupillai, D. Chia, S. Al Majid, Aafreen E. Matloob Ahmad, A. Hounat, S. Shafi, J. Wang, W. A. Cambridge, L. Kawar, T. Maseland, K. Sharma, J. Moses, M. A. Patsalides, S. Brown, A. Jaffer, K. Feeney, G. Richardson, Josiah P. Joseph, L. Argus, X. Sara, A. Antypas, M. de Andres Crespo, E. Daly, S. Abraha
Journal: International Journal of Surgery (2021)
It’s Time to Rethink (and Retrial) Our Framework for Stroke Prevention in Atrial Fibrillation
Authors: Mintu P. Turakhia
Journal: JAMA Cardiology (2021)

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1101MO Development of CAR T-cells for future treatment of NETs
Authors: B. Mandriani, E. Pelle', F. Mannavola, G. Ingravallo, G. Cazzato, M.C. Ramello, C.G. Porta, J.R. Strosberg, D. Abate-Daga, M. Cives
Journal: Annals of Oncology (2021)
1327P Impact of bone targeted agents (BTA) in advanced non-small cell lung cancer (aNSCLC) patients (pts) with high bone tumor burden (HBTB) treated with PD(L)1 inhibitors (ICIs)
Authors: S. Manglaviti, M. Bini, G. Apollonio, E. Zecca, A. Labianca, G. Galli, M. Brambilla, M. Occhipinti, C. Proto, A. Prelaj, D. Signorelli, A. De Toma, G. Viscardi, T. Beninato, E. Zattarin, E. Galli, M.C.C. Garassino, F.G.M. de Braud, G. Lo Russo, R. Ferrara
Journal: Annals of Oncology (2021)
9P Click Activated Protodrugs Against Cancer (CAPAC) platform enhances the safety, pharmacokinetics, and antitumor efficacy of cancer therapies in vivo
Authors: S. Srinivasan, N.A. Yee, A. Mahmoodi, M. Zakharian, M.W. Saville, J.M. Mejía Oneto
Journal: Annals of Oncology (2021)
CN18 Nutritional status in locally advanced or metastatic solid cancer patients in Spain: The NutriOncoSearch (NOS) study
Authors: J.C. de la Torre-Montero, J. Serra López, R. Alvárez García, M. Magdalena Batle Vidal, N. Gil Gómez, P. Beorlegui Murillo, A. Salieto Tecles, A. Sánchez Belchiz, I. Amoscotegui, E. Medina Cruz, Y. Iragorri Barberena, D. Pérez Cárdenas, C. Garrido Caricol, C. Rubio Uría, I. Tuñón Cabeza, M. González Suárez, M.C. Del Río Pisabarro, S.M. Amoró Cerdá, I. González Álvarez, C. Pujol Besora
Journal: Annals of Oncology (2021)
LBA8 Vaccination against SARS-CoV-2 in patients receiving chemotherapy, immunotherapy, or chemo-immunotherapy for solid tumors
Authors: S. Oosting, A.A.M. Van der Veldt, C.H. GeurtsvanKessel, R.S.N. Fehrmann, R.S. van Binnendijk, A-M.C. Dingemans, E.F.F. Smit, T.J.N. Hiltermann, G. den Hartog, M. Jalving, T. Westphal, A. Battacharya, M. van der Heiden, C.U. Blank, M.P. Koopmans, C.A. van Els, N.Y. Rots, D. van Baarle, J.B.A.G. Haanen, E.G. de Vries
Journal: Annals of Oncology (2021)
Association of Demographic Factors and Medical School Experiences With Students’ Intention to Pursue a Surgical Specialty and Practice in Underserved Areas
Authors: Mytien Nguyen, Michele Cerasani, Liban A. Dinka, Jeslyn A. Rodriguez, Moje Omoruan, Ernesto Acosta, Kareme D. Alder, Nicholas N. Brutus, Paula M. Termuhlen, Alan Dardik, Hyacinth R. C. Mason, Steven C. Stain
Journal: JAMA Surgery (2021)

The surgical workforce shortage is a threat to promoting health equity in medically underserved areas. Although the Health Resources and Services Administration and the American College of Surgeons have called to increase the surgical pipeline for trainees to mitigate this shortage, the demographic factors associated with students' intention to practice in underserved areas is unknown.To evaluate the association between students' demographics and medical school experiences with intention to pursue surgery and practice in underserved areas.This cross-sectional study surveyed graduating US allopathic medical students who matriculated between 2007-2008 and 2011-2012. Analysis began June 2020 and ended December 2020.Intention to pursue surgery and practice in underserved areas were retrieved from the Association of American Medical Colleges graduation questionnaire. Logistic regression models were constructed to evaluate (1) the association between demographic factors and medical students' intention to pursue surgical specialties vs medical specialties and (2) the association between demographic factors and medical school electives with intention to practice in underserved areas.Among 57 307 students who completed the graduation questionnaire, 48 096 (83.9%) had complete demographic data and were included in the study cohort. The mean (SD) age at matriculation was 23.4 (2.5) years. Compared with students who reported intent to pursue nonsurgical careers, a lower proportion of students who reported intent to pursue a surgical specialty identified as female (3264 [32.4%] vs 19 731 [51.9%]; χ2﻿ P < .001). Multiracial Black and White students (adjusted odds ratio [aOR], 1.72; 95% CI, 1.11-2.65) were more likely to report an intent for surgery compared with White students. Among students who reported an intention to pursue surgery, Black/African American students (aOR, 3.24; 95% CI, 2.49-4.22), Hispanic students (aOR, 2.00; 95% CI, 1.61-2.47), multiracial Black and White students (aOR, 2.27; 95% CI, 1.03-5.01), and Indian/Pakistani students (aOR, 1.31; 95% CI, 1.02-1.69) were more likely than White students to report an intent to practice in underserved areas. Students who reported participating in community health (aOR, 1.61; 95% CI, 1.42-1.83) or global health (aOR, 1.83; 95% CI, 1.61-2.07) experiences were more likely to report an intention to practice in underserved areas.This study suggests that diversifying the surgical training pipeline and incorporating health disparity and community health in undergraduate or graduate medical education may promote students' motivation to practice in underserved areas.
407P Neoadjuvant chemo-radiotherapy response in patients affected by mismatch repair deficient (dMMR) locally advanced rectal cancer
Authors: A. Pretta, C. Donisi, M. Persano, G. Pinna, E. Cimbro, A. Parrino, V. Aimola, D. Spanu, G. Cerrone, S. Deidda, M.A. Deidda, V. Pusceddu, M. Puzzoni, P. Ziranu, R. Barbara, A. Restivo, L. Zorcolo, G. Faa, M. Scartozzi
Journal: Annals of Oncology (2021)
Abstract P191: Orthostatic Hypotension and Blood Pressure Symptoms in the AASK Cohort Study
Authors: Stephen P Juraschek, Edgar R Miller, Lawrence J Appel
Journal: Circulation (2017)

Background: Orthostatic hypotension (OH) is defined using a consensus-based definition, namely, a drop in systolic blood pressure (SBP) ≥20 mmHg or diastolic BP (DBP) ≥10 mmHg or an increase in heart rate (HR) ≥20 bpm. Whether or not these definitions correspond with patient symptoms is unknown. Hypothesis: Traditional metrics for defining OH are arbitrary and warrant revision. Methods: SBP, DBP, and HR were assessed after 5 min in the rested, seated position and after 1 min of standing in black participants at each visit of the AASK cohort study (2002-2007; n=677). Postural change was determined by subtracting the seated SBP, DBP, or HR from the standing SBP, DBP, or HR. During each visit, participants were asked whether they experienced 26 distinct BP-related symptoms since last visit (yes or no). Relationships between SBP, DBP, and HR and symptoms were modeled via generalized estimating equations. Results: Participants were 40% women; mean age was 60 yrs (SD, 10) and mean number of follow-up visits was 19 (10). Mean (SD) resting SBP, DBP, and HR at baseline were 136 mmHg (22), 81 mmHg (13), and 69 bpm (12). After adjustment for age and sex, dizziness was the only symptom associated with all components of OH: SBP per -10 mmHg (OR 1.13; 95% CI 1.03, 1.23), DBP per -10 mmHg (1.12; 1.00, 1.26), and HR per 10 bpm (1.14; 1.03, 1.26). Light-headedness was associated with SBP (1.12; 1.03, 1.21) and HR (1.14; 1.05, 1.24), but non-significantly with DBP (1.11; 0.99, 1.23). When plotted continuously, there was no clear demarcation of risk between symptoms and conventional cut points. Rather, reduction in standing SBP and DBP were each associated with a higher proportion of symptoms at about -5 mm Hg, while increase in standing HR was associated with a higher proportion of symptoms as low as 5 bpm ( Figure ). Conclusions: Dizziness and light-headedness are symptoms most strongly associated with OH. The proportion with symptoms is greater at cut points less extreme than the consensus definition, demonstrating that the consensus definition of OH lacks sensitivity.
964MO Entinostat, nivolumab and ipilimumab in advanced HER2-negative breast cancer (ETCTN-9844)
Authors: E.T. Roussos Torres, J. Leatherman, C. Rafie, A. Brufsky, P. Lorusso, J.P. Eder, V. Chung, Y. Yuan, M. Downs, A. O’Connor, R. Piekarz, H. Streicher, M.A. Rudek, Q. Zhu, E. Fertig, R.A. Anders, A. Cimino-Mathews, E.M. Jaffee, V. Stearns, R.M. Connolly
Journal: Annals of Oncology (2021)
Nivolumab-associated DRESS in a genetic susceptible individual
Authors: Luoyan Ai, Jie Gao, Shihai Zhao, Qian Li, Yue-Hong Cui, Qing Liu, Duojiao Wu, Yimei Wang, Xiaoshi Jin, Yuan Ji, Jingjie Li, Yiyi Yu, Tianshu Liu
Journal: Journal for ImmunoTherapy of Cancer (2021)

The use of immune checkpoint inhibitors (ICIs) is rising exponentially in numerous cancers, but immune-related adverse events can occur. We report a rare case of high-grade drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome developed stepwise in a patient with gastric cancer after nivolumab treatment. Subclinical myocarditis was sensitively detected by cardiovascular magnetic resonance 3 weeks after initiating nivolumab. Eruption, eosinophilia, and interstitial pneumonitis occurred 1 week later. Corticosteroids were started and his condition improved. Four months later, when he was still on steroids tapering off, acute kidney injury and sequential herpes zoster virus activation developed. Severe acute tubulointerstitial nephritis (ATN) with an intense infiltration of lymphocytes was observed on renal biopsy. In blood, a substantial shift to Th2 response, an increase of Th17 cells, and strikingly enriched granzyme B + and perforin + CD8 + T cells were detected at ATN onset. Serum interleukin (IL)-5, IL-17, interferon gamma, and IL-6 levels were consistently elevated. Further molecular profiling identified a DRESS risk allele human leukocyte antigen (HLA)-A*31:01 in this patient. His ATN responded favorably to a high dose of corticosteroids. In parallel, complete antitumor response was observed during the clinical course of DRESS. This is the first ever case report of nivolumab-associated DRESS syndrome with exploration of the mechanisms from the histopathological, cellular and molecular aspects. Nivolumab-induced DRESS may result from type IV hypersensitivity-related ‘off-target effect’ and PD-1 block-mediated ‘on-target effect’. HLA risk alleles may constitute the genetic susceptible basis. HLA typing assay has the potential to screen susceptible individuals to avoid ICI-induced DRESS.
c-MAF–dependent perivascular macrophages regulate diet-induced metabolic syndrome
Authors: Hernandez Moura Silva, Jamil Zola Kitoko, Camila Pereira Queiroz, Lina Kroehling, Fanny Matheis, Katharine Lu Yang, Bernardo S. Reis, Christine Ren-Fielding, Dan R. Littman, Marcelo Torres Bozza, Daniel Mucida, Juan J. Lafaille
Journal: Science Immunology (2021)

Macrophages are an essential part of tissue development and physiology. Perivascular macrophages have been described in tissues and appear to play a role in development and disease processes, although it remains unclear what the key features of these cells are. Here, we identify a subpopulation of perivascular macrophages in several organs, characterized by their dependence on the transcription factor c-MAF and displaying nonconventional macrophage markers including LYVE1, folate receptor 2, and CD38. Conditional deletion of c-MAF in macrophage lineages caused ablation of perivascular macrophages in the brain and altered muscularis macrophages program in the intestine. In the white adipose tissue (WAT), c-MAF–deficient perivascular macrophages displayed an altered gene expression profile, which was linked to an increased vascular branching. Upon feeding high-fat diet (HFD), mice with c-MAF–deficient macrophages showed improved metabolic parameters compared with wild-type mice, including less weight gain, greater glucose tolerance, and reduced inflammatory cell profile in WAT. These results define c-MAF as a central regulator of the perivascular macrophage transcriptional program in vivo and reveal an important role for this tissue-resident macrophage population in the regulation of metabolic syndrome.
1005P A new platform of personalized neoantigen cancer vaccines directed by checkpoint inhibitor antibodies to improve cancer immunity
Authors: Y. Mishima, F. Isoda, N. Matsumoto, K. Hiranuka, T. Yamada, N. Fujinami, M. Shimomura, T. Suzuki, T. Nakatsura, N. Nakamura
Journal: Annals of Oncology (2021)