tbuckley/cabot-search huggingface dataset:
Meine myelogenetische Hirnlehre, mit biographischer Einleitung.
Journal: JAMA (1928)

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Auto-Antibodies in Pulmonary Diseases
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pivotal role of Cu,Zn-superoxide dismutase in endothelium-dependent hyperpolarization
Authors: Keiko Morikawa, Hiroaki Shimokawa, Tetsuya Matoba, Hiroshi Kubota, Takaaki Akaike, M.A. Hassan Talukder, Makoto Hatanaka, Takako Fujiki, Hiroshi Maeda, Shosuke Takahashi, Akira Takeshita
Journal: Journal of Clinical Investigation (2003)

The endothelium plays an important role in maintaining vascular homeostasis by synthesizing and releasing several vasodilating factors, including prostacyclin, NO, and endothelium-derived hyperpolarizing factor (EDHF). We have recently identified that endothelium-derived H2O2 is an EDHF in mesenteric arteries of mice and humans and in porcine coronary microvessels. However, the mechanism for the endothelial production of H2O2 as an EDHF remains to be elucidated. In this study, we tested our hypothesis that Cu,Zn-superoxide dismutase (Cu,Zn-SOD) plays a pivotal role in endothelium-dependent hyperpolarization, using control and Cu,Zn-SOD–/– mice. In mesenteric arteries, EDHF-mediated relaxations and hyperpolarizations were significantly reduced in Cu,Zn-SOD–/– mice with no inhibitory effect of catalase, while endothelium-independent relaxations and hyperpolarizations were preserved. Endothelial H2O2 production also was significantly reduced in Cu,Zn-SOD–/– mice. In Langendorff isolated heart, bradykinin-induced increase in coronary flow was significantly reduced in Cu,Zn-SOD–/– mice, again with no inhibitory effect of catalase. The exogenous SOD mimetic tempol significantly improved EDHF-mediated relaxations and hyperpolarizations and coronary flow response in Cu,Zn-SOD–/– mice. These results prove the novel concept that endothelial Cu,Zn-SOD plays an important role as an “EDHF synthase” in mice, in addition to its classical role to scavenge superoxide anions.
Table of Contents
Authors: Deidra Crews, Aminu Bello, Gamal Saadi, A Kitching, Stephen Holdsworth, Mario Nuvolone, Giampaolo Merlini, Keith Hruska, Moe Mahjoub, Dominic Summers, Gavin Pettigrew, Brad Rovin, Salem Almaani, Ana Malvar, Jürgen Floege, Sean Barbour, Daniel Cattran, Jonathan Hogan, Patrick Nachman, Sydney Tang, Jack Wetzels, Michael Cheung, David Wheeler, Wolfgang Winkelmayer, Dawn Caster, Keisha Gibson, Marcus Moeller, Dario Roccatello, Bernard Canaud, Jeroen Kooman, Nicholas Selby, Maarten Taal, Susan Francis, Pascal Kopperschmidt, Andreas Maierhofer, Peter Kotanko, Jens Open, Vivek Kasinath, Osman Yilmam, Mayuko Uehara, Liwei Jiang, Farideh Ordikhani, Xiaofei Li, David Salant, Reza Abdi, Liming Wang, Jae-Hyung Chang, Anne Buckley, Robert Spurney, Martin Späth, Malte Bartram, Nicolàs Palacio-Escat, Johanna Hoyer, Cedric Debes, Fatih Demir, Christina Schroeter, Amrei Mandel, Franziska Grundmann, Giuliano Ciarimboli, Andreas Beyer, Jayachandran Kizhakkedathu, Susanne Brodesser, Heike Göbel, Jan Becker, Thomas Benzing, Bernhard Schermer, Martin Höhne, Volker Burst, Julio Saez-Rodriguez, Pitter Huesgen, Roman-Ulrich Müller, Markus Rinschen, Takafumi Yagisawa, Toshiaki Tanaka, Satoshi Miyairi, Kazunari Tanabe, Nina Dvorina, Wayne Yokoyama, Anna Valujskikh, William Baldwin, Robert Fairchild, Michaela Finsterbusch, M Norman, Pam Hall, Michael Hickey, Faik Imeri, Karen Nolan, Andreas Bapst, Sara Santambrogio, Irene Abreu-Rodríguez, Patrick Spielmann, Svende Pfundstein, Silvana Libertini, Lisa Crowther, Ilaria Orlando, Sophie Dahl, Anna Keodara, Willy Kuo, Vartan Kurtcuoglu, Carsten Scholz, Weihong Qi, Edith Hummler, David Hoogewijs, Roland Wenger
Journal: Kidney International (2019)
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Authors: Nariman Sepehrvand, Wendimagegn Alemayehu, Justin Ezekowitz
Journal: JAMA Cardiology (2020)

In Reply We thank Fernandes et al for their interest in our study 1 and agree that this field requires further exploration.Explanatory trials are primed to maximize the likelihood of finding efficacy of an intervention by testing it in an ideal setting, whereas pragmatic trials aim to test effectiveness of an intervention in a more generalizable setting.Hence, they are expected to generate more generalizable results, with the risk understood that there may be more variation in less tightly controlled environments, which may result in differing results.In our study, 1 380 of 616 randomized clinical trials (61.7%) were positive for the primary end point, 56 (9.1%) were neutral for the primary end point but positive for at least one secondary end point, and 180 (29.2%) were neutral for both the primary and secondary end points.The proportion of trials with positive results was fairly stable over time, with 113 of 172 (65.7%), 104 of 168 (61.9%), 76 of 137 (55.5%), and 87 of 139 (62.6%) in 2000, 2005, 2010, and 2015, respectively.Compared with trials with neutral findings, randomized clinical trials that were positive for the primary end point had lower mean [SD] Pragmatic Explanatory Continuum Index Summary (PRECIS)-2 scores (3.17 [0.70] vs 3.42 [0.66]; P < .001);however, the Cohen d effect size of 0.36 denotes a small difference in the level of pragmatism between trials with positive and neutral findings. 1However, we would caution against the interpretation that the level of pragmatism is the root cause for the neutral results in these trials.Many other factors can play a role in the neutral findings, including the lack of an actual effect, the type of question being addressed, operational considerations, and patient or health system factors, among others.This is analogous to the considerations to trials using surrogate end points (eg, biomarkers), as trials with surrogate markers often yield positive results compared with trials that are focused on clinical end points. 2Pragmatic trials complement explanatory trials, as the intent is different, and we need to be comfortable that not all interventions work as hypothesized.
Troubles de la fonction gastrique et syndromes associés chez les tuberculeux pulmonaires.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE SECTION ON STOMATOLOGY.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Late follow-up of Persistent Truncus Arteriosus, after one-stage Repair, with Right Ventricular Remodeling.
Authors: Miguel Maluf
Journal: Clinical Cardiology and Cardiovascular Interventions (2021)

We report long-term outcome after one-stage, surgical repair, in a two months-old girl with persistent truncus arteriosus type I, II. The operation was carried out with the remodeling of the right ventricle, using a swine bicuspid pulmonary prosthesis. Twenty-six years later, the patient is in excellent clinical condition, CF I (NYHA), with normal peripheral oxygen saturation. Recent invasive and not invasive imaging show: absence of intracardiac shunt and growing of the right ventricle outlet tract and discrete double lesion of the pulmonary valve. The pulmonary flow directed uniformly for both lungs. In selected cases, the long-term prognosis of patients with persistent truncus arteriosus, undergoing early surgical repair, avoiding the use of valved conduit, makes for an excellent evolution, without new interventions. Endovascular procedures, now well standardized, for the implantation of a pulmonary valve stent, through a catheter, will allow an effective approach, in the presence of late obstructions, in patients who have undergone right ventricular remodeling, without the use of valved conduits.
THE EQUIPMENT OF THE MODERN PHYSICIAN.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prenatal identification of paternity. HLA typing helpful after rape
Authors: M. S. Pollack
Journal: JAMA (1980)

The HLA antigen system is extremely polymorphic, and HLA typing is now widely used for both the exclusion and the positive assignment of paternity. We have also used HLA typing for identification of paternity of fetal cells in a pregnancy detected a few weeks after the rape of a woman. The HLA typing indicated that the father of the fetus was the woman's husband, with a probability of 25:1 (96%), before the time the rapist could also be tested. Subsequently, the accused rapist was excluded as a potential father because he lacked all of the paternal antigens detected in the fetus. This prediction was confirmed after delivery. (<i>JAMA</i>244:1954-1956, 1980)
Marriages
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Water disinfection: microbes versus molecules—an introduction of issues
Authors: John R. Fowle, Frederick C. Kopfler
Journal: Environmental Health Perspectives (1986)

“Water is, apart from the air one breathes, the only nutrient which is, as a matter of necessity, consumed by every human being from the first day to the last day of his existence, and it is consumed in considerably larger quantities than any other nutritional substance.”(1)
Reference Committees 1985 Interim Meeting
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CEREBRAL DECOMPRESSION.PALLIATIVE OPERATIONS IN THE TREATMENT OF TUMORS OF THE BRAIN, BASED ON THE OBSERVATION OF FOURTEEN CASES.
Authors: WILLIAM G. SPILLER
Journal: JAMA (1906)

Palliative operations in cases of brain tumor are not new, and the temporary benefits to be derived in this way have been fully recognized by many physicians during many years. It has seemed time well spent to examine some of the reports of cases treated by trephining, or other method of opening the skull, for the relief of pressure when a tumor could not be localized, or if localized could not be removed. Unquestionably many cases have been omitted, and yet I have collected sufficient to demonstrate that palliative treatment has an important place in cerebral surgery. <h3>REVIEW OF LITERATURE.</h3> Annandale<sup>1</sup>said, in 1894, that more than twenty years previously he had opened the skull of a patient whose symptoms were those of general brain pressure and, although no special condition was found, temporary relief was marked. Another case of this kind, he says, was operated on by Sir
Leads from the MMWR. Creutzfeldt-Jakob disease in a second patient who received a cadaveric dura mater graft
Journal: JAMA (1989)

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<i>ERJ</i> September Podcast: The hidden burden of severe asthma
Journal: European Respiratory Journal (2017)

As part of the September issue, the European Respiratory Journal presents the latest in its series of podcasts. Chief editor Marc Humbert discusses the publication of the results of a survey of patients with severe asthma with Prof. Helen K. Reddel from the University of Sydney, Sydney, and the NHMRC Centre for Research Excellence in Severe Asthma, Newcastle, Australia.
The Hospitals of London.--No. VI
Authors: None Cormack, None Semple
Journal: BMJ (1851)

The following is introduced in this place, from the similarity of the general results to those of the London hospitals, as formerly alluded to in this department of the LONDON JOURNAL OF MEDICINE; and as illustrated by Dr. Webster in the present number.GENERAL HOsPITAL AT VIENNA.The subjoined Statistical Reports of the General Hospital at Vienna for 1848 and 1849, are contained in the Zeitchrift der K. K. Gesellchaft der Aerzte m Wien for November and December 1849, and Sept. and Oct. 1850.If we could obtain room, we should like to reproduce them entire, as excellent models for the compilation of similar returns from the London hospitals.In the mean time, we have combined some of the statistics regarding the mortality in the institution at Vienna.Table exhibiting the Rate of Mortality in the Wards of the Generl Hosial in Vienna, during the years 1848 and 1849.
DNR Orders and Medical Futility
Authors: Ronald Epstein
Journal: JAMA (1995)

<h3>To the Editor.</h3> —It is not surprising that residents should have poor skills in areas where they have received no training. Studies on the delivery of bad news, obtaining informed consent, taking a sexual history, discussing end-of-life issues, and now of determining futility indicate that many of these tasks are performed poorly.<sup>1</sup>All require high-order communication skills, emotional maturity, capacity for accurate empathy, and time. These skills are difficult to cultivate and require practice, experience, and active critique. If these complex skills are important, employed often, and involve major life-and-death decisions, why is there so little time in medical education devoted to the cultivation of advanced communication skills? In addition to developing ethical arguments for criteria for medical futility, we must train students and residents in these communication skills. Otherwise, abstract reasoning will take the place of care that respects the values of the person who is receiving it.
The role of the addictive process as a key step in causation of all tobacco-related diseases
Authors: W. Pollin
Journal: JAMA (1984)

Two circumstances—the fact that cigarette smoking is the single largest preventable cause of disease and death in the country<sup>1</sup>and the rapid development of a new body of knowledge concerning the addictive process—combine to provide an unparalleled opportunity for American medicine to fulfill its primary responsibility—"the reduction of suffering and death."<sup>2</sup> The magnificent neuroadaptability of our species at times becomes dangerous and expensive. We can, unfortunately, come to accept familiar and well-known situations as givens, a part of the landscape. As a result of this adaptability, we frequently overlook important factors that have become so familiar they have lost their saliency. Applied to cigarette smoking, we need to see relative burdens of mortality and morbidity more clearly again, as for the first time. The 350,000 excess deaths per year attributable to cigarette smoking constitute more than all other drug and alcohol abuse deaths combined, seven times more than