tbuckley/cabot-search huggingface dataset:
THE TREATMENT OF HEMOPHILIA.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vitamin D status in different subgroups of British Asians.
Authors: S P Hunt, J L O'Riordan, J Windo, A S Truswell
Journal: BMJ (1976)

To assess the effect of religious dietary practices and social customs on the vitamin D status of Asian immigrants, we kept records of the dietary intake and time spent out of doors of 81 Ugandan Asian men, women, and girls (9-19 years old). Sera were analysed for 25-hydroxycholecalciferol (25-OHD3), and 28% of the subjects were found to have levels below the lower limit of normal. The (vegetarian) Hindus had the lowest dietary intakes, least time out of doors, and lowest serum 25-OHD3. The Goan (Roman Catholic) Asians, despite more pigmentation, had 25-OHD3 levels similar to those found among indigenous British people and had the most satisfactory vitamin D intakes. Among Asians, whose exposure to sunlight may be limited, dietary vitamin D becomes the major determinant of serum 25-OHD3.
Nitroprusside-induced intracranial hypertension
Authors: W. R. Griswold
Journal: JAMA (1981)

<h3>In Reply.—</h3> Dr Portnoi's letter raises many interesting issues and presents viewpoints on many diverse subjects. We agree with some of the stances offered (the need for an organized system of health care for the elderly) and question others (that the solution to the ills of British geriatrics is to be found in shifting its emphasis to the community). We make this last point despite our interest in out-of-institution care; Boston University has a home medical service that dates to the 19th century and that is an integral part of geriatric medicine. Furthermore, we applaud many of Dr Portnoi's well-known efforts in geriatrics at George Washington University. Nonetheless, the contents of his letter seem to bear little relevance to our description of a university hospital consultative service that was "designed to provide a comprehensive consultation for the geriatric patient at a short-term care university hospital" where 45% of the general
<i>Psychiatric-Neurologic Examination Methods. With Special Reference to the Significance of Signs and Symptoms</i>. By Dr. August Wimmer, Director St. Hans Hospital, Roskilde near Copenhagen. Authorized Translations by Andrew W. Hoisholt, M. D., Medical Superintendent Napa State Hospital, Napa, California, etc. (<i>St. Louis: C. V. Mosby Company, 1919.</i>)
Journal: American Journal of Psychiatry (1920)
吸烟者中的化脓性汗腺炎的发生率:一项在美国开展的基于人群的回顾性分析
Authors: A. Garg, V. Papagermanos, M. Midura, A. Strunk
Journal: British Journal of Dermatology (2018)

化脓性汗腺炎(HS)是一种痛苦的复发性慢性疾病,其炎症出现于大汗腺部位。这些腺体主要位于腋窝和腹股沟。在HS中,毛囊可能会被堵塞。这会导致烫伤样的肿块、部位化脓并留下疤痕。尽管普遍观念认为,吸烟会增加感染该疾病的风险,然而相关证据仍存在争议。本项研究的重要之处在于,它包含了相当大规模的人群样本,以比较HS在吸烟者和非吸烟者中的发病率。研究人员利用美国的医疗保健数据识别出3924310名吸烟者和8027790名非吸烟者,并且发现吸烟者和非吸烟者的HS总体发病率分别为0.20%和0.11%。吸烟者中以下人群的HS发病率最高:30~39岁的人(0.35%)、女性(0.28%)、非裔美国人(0.46%)和BMI≥30的人。结论是,吸烟者中的HS发病率比非吸烟者几乎翻了一番。这些发现可能可以支持基于证据的建议,以帮助具有HS患病风险的人戒烟。
The White Spots of Epilepsy and Other Phases of the Disease.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Psychiatry
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Eradication of Hepatitis C Virus after Interferon-α Therapy
Authors: Raffaella Romeo
Journal: Annals of Internal Medicine (1995)

Letters15 March 1995Eradication of Hepatitis C Virus after Interferon-α TherapyRaffaella Romeo, Stanislas Pol, and Christian BrechotRaffaella RomeoSearch for more papers by this author, Stanislas PolSearch for more papers by this author, and Christian BrechotSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-6-199503150-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree with Dr. Agnello that a few copies of HCV RNA may exist after interferon treatment even if PCR results are negative. Nevertheless, the inability to detect HCV RNA in the serum, liver, and peripheral blood mononuclear cells is a strong argument for eradication, given the long-term follow-up of these patients who continue to have normal liver function and normal liver histologic results. A longer follow-up of these patients should confirm our hypothesis of the absence of substantial HCV infection.In regard to the letter by Dr. Akpolat and colleagues, we never stated that hemodialysis was a ...References1. Pol S, Thiers V, Carnot F, et al. Efficiency of α-2b interferon in the treatment of HCV infection in hemodyalized patients (Abstract). Hepatology. 1994; 20:253. Google Scholar2. Lindsay KL, El-Shahawy M, Milstein S, et al. HCV RNA levels are lowered during hemodialysis in patients with chronic hepatitis C (Abstract). Hepatology. 1994; 20:570. Google Scholar3. Nousbaum JB, Pol S, Nalpas B, Landais P, Berthelot P, Brechot C, et al. Hepatitis C virus type II (1b) in Europe. Decreasing prevalence over the last decade; its association with cirrhosis, hepatocellular carcinoma and low response to interferon α. Ann Intern Med. 1995; 122:161-8. Google Scholar4. Pol S, Debure A, Degott C, et al. Chronic hepatitis in kidney allograft recipients. Lancet. 1990; 335:878-80. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 March 1995Volume 122, Issue 6Page: 474-475KeywordsBlood cellsCellsDrugsHepatitis C virusInterferonsLiverRNARenal diseasesRenal transplantationViremia ePublished: 15 August 2000 Issue Published: 15 March 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Recredentialing
Authors: Donald G. Langsley
Journal: JAMA (1991)

Two interdependent themes that dominate current thinking about health care are periodic physician recredentialing and standard setting. The goals are said to be assurance of quality of care, competence of the practitioner, and cost containment. The New York State proposal described by Gellhorn<sup>1</sup>is an example of the use of the power of licensure for periodic review of the individual physician's competence. Though patently unpopular—who wants to be retested?—it deserves critical appraisal. The 23 states that require continuing medical education as a condition of reregistration of the medical license hoped that this would assure competence. Unhappily, there has been little evidence that continuing medical education alters practice and no guarantee that physicians choose the courses that are most needed in their practice.<sup>2</sup> From its beginnings, the American Board of Medical Specialties espoused the necessity for time-limited rather than lifetime certification. A 1973 resolution that called for voluntary recertification
COUNCIL ON MEDICAL SERVICE
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Poly(I:C) promotes the production of <scp>IL</scp>‐17A by murine <scp>CD</scp>1d‐driven invariant <scp>NKT</scp> cells in airway inflammation
Authors: A. Vultaggio, F. Nencini, S. Pratesi, G. Petroni, S. Romagnani, E. Maggi
Journal: Allergy (2012)

Abstract Background IL ‐17 A is associated with different asthma phenotypes as virus‐associated or steroid‐resistant asthma. Invariant natural killer T ( iNKT ) cells play an important role in the pathogenesis of asthma. The aim of the study was to evaluate the activity of polyinosinic–polycytidylic acid [poly( I : C )] on IL ‐17 A production by CD 1d‐activated iNKT cells. Methods We analysed the in vitro effect of poly( I : C ) on the release of IL ‐17 A by spleen and lung CD 1d‐activated iNKT cells with α‐galactosylceramide (α‐ G al C er). Its activity was also investigated in an α‐ G al C er‐induced murine models, including lung inflammation. The inhibition of IL ‐17 A by Toll‐like receptor ( TLR ) 7 agonists in the same in vitro and in vivo models has been analysed. Results Poly( I : C ) upregulated the in vitro IL ‐17 A production by CD 1d‐activated NK 1.1− CD 4− iNKT subset, without modifying type 1 and type 2 cytokines. The two stimuli selectively upregulated IL ‐17A serum levels in vivo . Their intratracheal administration resulted in increased airway hyper‐reactivity ( AHR ), neutrophilia in bronchoalveolar lavage and airway inflammation, which were inhibited by anti‐ IL ‐17 A antibody. Poly( I : C ) effects were attributable to IL 1β and IL ‐23 release from dendritic cells, as showed by inhibition with neutralizing antibodies. TLR 7 agonists inhibited the IL ‐17A production by poly( I : C ) plus α‐ G al C er in the same models. Such effect was associated with the increased production by DC of IL ‐17 A ‐inhibiting cytokines and the dampening of IL ‐1β and IL ‐23. Conclusions Synthetic ds RNA selectively expand a CD 1d‐driven IL ‐17 A ‐producing iNKT cell subset, thus explaining the worsening of airway inflammation by some viral infections. TLR 3‐ and TLR 7‐triggering viral sequences can exert variable and opposite effects on adaptive immune response.
Venous Aneurysms
Authors: Irwin J. Schatz, Gerald Fine
Journal: New England Journal of Medicine (1962)

SUBCUTANEOUS masses may present a problem in differential diagnosis. Aneurysmal dilatation of a localized segment of a vein occurring in the absence of associated varicose veins is a rare phenomenon but, when present, may be mistaken for other tumors in the subcutaneous tissues. The purpose of this report is to emphasize the clinical patterns in 5 cases of venous aneurysm in an attempt to aid in accurate preoperative diagnosis. In addition, the histologic features in 4 of these cases are discussed.Case ReportsCase 1. A 49-year-old white assembly-line worker (H.F.H.755656) was seen on June 12, 1961, because of . . .
ANTIDIPHTHERIC SERUM AND POSTDIPHTHERIC PARALYSIS.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Purified influenza virus vaccine. A study of viral reactivity and antigenicity
Authors: F. B. Peck
Journal: JAMA (1968)

The development of procedures for the use of the K-II continuous flow zonal ultracentrifuge has resulted, for the first time, in the availability of large quantities of highly purified influenza virus vaccine essentially free of nonviral egg-derived material. With these vaccines, it was determined that the inherent toxicity of purified virus strains and combinations thereof is uniformly low, and that the variable side effects frequently seen with conventionally produced vaccines are not virus related. Purified vaccines are equal in antigenicity to equivalent doses of conventional vaccines, demonstrating that nonviral components of conventional vaccine have no beneficial effects on vaccine antigenicity. Purified vaccine of twice normal potency is no more reactogenic than the same vaccine in standard doses, indicating that future vaccines of even higher potency and low reactivity are well within the realm of possibility.
Liver-targeted antiviral nucleosides: Enhanced antiviral activity of phosphatidyl-dideoxyguanosine versus dideoxyguanosine in woodchuck hepatitis virus infection in vivo
Authors: B Korba
Journal: Hepatology (1996)

It would be desirable to develop antiviral agents that can be targeted to liver to enhance their antiviral effects and reduce nonhepatic toxicity. 2',3'-Dideoxyguanosine (ddG) has been found to be a potent and selective antihepatitis B agent both in vitro and in vivo. To evaluate ddG and its liver-targeted analog, we synthesized a series of phosphatidyl-ddGs and incubated them with 2.2.15 cells, which chronically produce hepatitis B virus. 1,2-Dipalmitoylphosphatidyl- dideoxyguanosine (DPP-ddG) inhibited the production of hepatitis B virus (HBV) DNA in the culture medium by 90% at 4.5 mumol/L versus 9.1 mumol/L for ddG, while the liposome vehicle itself had no effect. To compare the efficacy of free ddG with its lipid prodrug in vivo, we treated woodchucks that were experimentally infected with woodchuck hepatitis virus (WHV) for 4 weeks by intraperitoneal injection of 2.6 mumol/kg/d of free ddG or liposomes containing 2.6 mumol/kg/d of DPP- ddG. Liposomal DPP-ddG reduced serum WHV DNA by 23- to 46-fold at the end of the fourth week, while free ddG reduced serum WHV DNA by 2.2- to 10.4-fold. Treatment with small unilamellar liposomes containing DPP- ddG is substantially more effective than free ddG in reducing WHV-DNA levels in serum in WHV-infected woodchucks. The data suggest that the use of lipid prodrugs to target the liver may be useful in enhancing antiviral therapy of hepatitis. (Hepatology 1996 May;23(5):958-63)
Hemolysis as a Possible Indicator of Neurotoxicity Induced by Organic Solvents
Authors: Rebecca J. Anderson, Carol E. Glasgow, Christopher B. Dunham
Journal: Environmental Health Perspectives (1984)

The expense, length of time and number of animals required for routine toxicity testing have provided the incentive for finding alternative techniques which are faster, less expensive and equally valid. The purpose of this work was to examine the value of a simple in vitro test (hemolysis) as a correlate of the neurotoxicity produced by commonly used industrial organic solvents. Incubation of rat erythrocytes with organic alcohols produced hemolysis which correlates with the potency of the same alcohols to suppress membrane excitability, measured as reduction in the evoked action potential of the rat sciatic nerve. The hemolytic activity also reflects changes in water solubility among the compounds and thus can be used as an index of in vivo neurotoxicity, the extent of which partly depends on absorption of the agent and delivery to nerve tissue. Hemolysis therefore may be of value as a preliminary test for assessing the neurotoxicity of organic solvents.
Use of Tracheal Organ Cultures in Toxicity Testing
Authors: Bernard P. Lane, Sandra L. Miller, Edward J. Drummond
Journal: Environmental Health Perspectives (1976)

Fragments of tracheal epithelium alone or in continuity with connective tissues, can be maintained in culture medium and used for short term or long term studies of toxicity of a variety of chemicals. Large numbers of uniform cultures are prepared with the aid of a slicing device or by application of simple method for dissecting sheets of epithelium free from underlying cartilage. The cultures may be placed in an exposure chamber-incubator mounted on a microscope stage and monitored continually for ciliostasis and exfoliation of cells. Morphology is further studied by fixation of selected specimens and preparation for light microscopy and electron microscopy. Synthetic functions are evaluated by autoradiographic measurement of incorporation of radioactive precursors into macromolecules and other dynamic features are indirectly assessed by histochemical and histoenzymatic methods. Short-term studies using these several techniques have shown that ciliostasis does not correlate with cell injury in all instances, and a long-term study has demonstrated dose dependence of a cytotoxic agent when duration of culture viability is measured. The method lends itself to a broad range of investigations in which dose, period of exposure, and role of cofactors must be independently and quantitatively assessed.
WATER
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Books Received
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal