tbuckley/cabot-search huggingface dataset:
“MUSHROOM-LIKE” GASTRITIS. AN UNUSUAL CASE OF LIFE-THREATENING UPPER GASTROINTESTINAL BLEEDING!
Authors: A Martins Pinto da Costa, E. Abad Izquierdo, L Relea Pérez, M Calvo Moya, E Santos Pérez, A. Dotor de Lama, M Vera Mendoza
Journal: Endoscopy (2022)

Eosinophilic gastritis is an infrequent inflammatory disorder characterized by eosinophilic infiltration of the stomach.
PROXIMAL SERRATED POLYP DETECTION RATE AND INTERVAL POST-COLONOSCOPY COLORECTAL CANCER RISK
Authors: D. van Toledo, J. Ijspeert, P. Bossuyt, M. Van Leerdam, M. Van Der Vlugt, I. Lansdorp-Vogelaar, M. Spaander, E. Dekker
Journal: Endoscopy (2022)

Aims The adenoma detection rate (ADR) is a well-established colonoscopy quality indicator and inversely associated with interval post-colonoscopy colorectal cancer (PCCRC) incidence. However, interval PCCRCs frequently develop from serrated polyps. The proximal serrated polyp detection rate (PSPDR) was advocated as quality indicator, but its association with interval PCCRCs has not yet been studied.
Anti-CCR9 chimeric antigen receptor T cells for T-cell acute lymphoblastic leukemia
Authors: Paul M. Maciocia, Patrycja A. Wawrzyniecka, Nicola C. Maciocia, Amy Burley, Thaneswari Karpanasamy, Sam Devereaux, Malika Hoekx, David O’Connor, Theresa Leon, Tanya Rapoz-D’Silva, Rachael Pocock, Sunniyat Rahman, Giuseppe Gritti, Diana C. Yánez, Susan Ross, Tessa Crompton, Owen Williams, Lydia Lee, Martin A. Pule, Marc R. Mansour
Journal: Blood (2022)
CONTRIBUTION OF GASTROSCOPY IN NON-VARICOSE UPPER GASTROINTESTINAL BLEEDING AND PREDICTIVE FACTORS FOR THE NEED FOR ENDOSCOPIC TREATMENT : A PROSPECTIVE STUDY
Authors: T. Addajou, S. Rokhsi, S. Mrabti, A. Benhamdane, A. Touibi, A. Sair, R. Berrida, I. Elkoti, F. Rouibaa, A. Benkirane, H. Seddik
Journal: Endoscopy (2022)

Aims The aim of our study is to evaluate the contribution of gastroscopy in non-varicose HDH and to assess the factors that predict the need for endoscopic haemostasis.
TRANSRECTAL ENDOSCOPIC DRAINAGE IN PATIENTS WITH ANASTOMOTIC LEAKS FOLLOWING RECTAL CANCER RESECTION
Authors: M. Jagielski, J. Piątkowski, G. Jarczyk, M. Jackowski
Journal: Endoscopy (2022)

Aims We assessed the efficacy and safety of transrectal endoscopic drainage by vacuum therapy in patients with intestinal anastomotic leakage after surgical treatment of middle and distal rectal tumors.
Effect of Mailing an At-home Disposal Kit on Unused Opioid Disposal After Surgery
Authors: Anish K. Agarwal, Daniel Lee, Zarina Ali, Yaxin Wu, Mary Coniglio, Tanya Uritsky, M. Kit Delgado
Journal: JAMA Network Open (2022)

This randomized clinical trial tests the effect of a mailed, at-home disposal kit on disposal rates of unused opioids after surgery.
Prognostic Potential of Postoperative 18F-Fluorocholine PET/CT in Patients With High-Grade Glioma. Clinical Validation of FuMeGA Postoperative PET Criteria
Authors: Ana María García Vicente, Francisco José Pena Pardo, Mariano Amo-Salas, Maikal Villena Martín, Carlos López Menéndez, Ángel María Soriano Castrejón, Julián Pérez-Beteta
Journal: Clinical Nuclear Medicine (2022)

Objective The aim of this study was to assess the prognostic performance of postoperative 18 F-fluorocholine PET/CT in patients with high-grade glioma (HGG). Methods Patients with HGG who underwent preoperative and postoperative 18 F-fluorocholine PET/CT were prospectively enrolled in the study. Postoperative MRI was classified as complete versus incomplete resection. Postoperative 18 F-fluorocholine PET/CT was classified as negative (complete) or positive for metabolic residual tumor (incomplete resection) using a 5-point score system. The correlation of positive locations on PET/CT with the sites of subsequent tumor recurrence was evaluated. The concordance of postoperative imaging techniques (Cohen κ ) and their relation with progression-free survival and overall survival were assessed using Kaplan-Meier method and Cox regression analysis. Results Fifty-one studies, belonging to 47 patients, were assessed. Four patients underwent 2 postoperative 18 F-fluorocholine PET/CT scans as they needed a second tumor resection for recurrence. In the follow-up, 42 patients progressed, and 37 died. Concordance between postoperative PET/CT and MRI assessment was poor. Resection grade on MRI did not show any significant association with prognosis. In multivariate analysis, only age and postoperative PET/CT showed significant association with progression-free survival (hazard ratio [HR], 1.03 [1.01–1.06, P = 0.006] and 1.88 [0.96–3.71, P = 0.067], respectively) and overall survival (HR, 1.04 [1.01–1.07, P = 0.004] and 2.63 [1.22–5.68, P = 0.014], respectively). Postoperative positive 18 F-fluorocholine PET/CT locations correlated with the sites of subsequent tumor recurrence in 81.82% of cases. Conclusion Postoperative 18 F-fluorocholine PET/CT seems superior to postoperative MRI in the outcome prediction of patients with HGG, outperforming it in the identification of the most probable location of tumor recurrence.
OUTCOMES AND LIMITATIONS OF EARLY ENDOSCOPIC DRAINAGE OF PANCREATIC AND PERIPANCREATIC NECROTIC COLLECTIONS
Authors: M. Jagielski, M. Zieliński, J. Piątkowski, M. Jackowski
Journal: Endoscopy (2022)

Aims Transmural endoscopic drainage is commonly used in the treatment of walled-off pancreatic necrosis in the late phase of acute necrotizing pancreatitis. This study aimed to prospectively evaluate and compare early endoscopic treatment in acute necrotic collections and that in walled-off pancreatic necrosis.
102P Long-term prediction of clinical outcomes by the 21-gene test in HR+ HER2- breast cancer patients with residual disease after neoadjuvant chemotherapy
Authors: V. Peg, N. de los Ángeles, B. Vieites, M. Bellet, C. Castilla, P. Gomez Pardo, A. Pérez-Luque, M.A. Lopez, F.J. Salvador Bofill, L. Alfaro, J.M. Perez Garcia, M. Espinosa-Bravo
Journal: Annals of Oncology (2022)
179P Time trends in overall survival and systemic therapy in patients with HR+/HER2- advanced breast cancer: A study of the SONABRE registry
Authors: M. Meegdes, S.M.E. Geurts, F.L.G. Erdkamp, W. Dercksen, B.E.P.J. Vriens, K.N.A. Aaldering, M.J.A.E. Pepels, L.V.D. Winkel, J. Tol, J.B. Heijns, A.J. van de Wouw, N. Peters, A.J.O. Fallois, M.A.C.E. van Kats, V.C.G. Tjan-Heijnen
Journal: Annals of Oncology (2022)
ENDOSCOPIC ULTRASOUND (EUS) GUIDED RADIOFREQUENCY ABLATION (RFA) FOR LIVER METASTASES: PRELIMINARY EXPERIENCE IN 14 CONSECUTIVE PATIENTS
Authors: A. Dancour, D.M Livovsky, G. Sheykman, M. Ben Haim, E. Goldin, T. Golan
Journal: Endoscopy (2022)

Aims Loco-regional treatments for liver metastasis from colorectal and pancreatic neuroendocrine (NET) tumors are based on surgical resection and/or transcutaneous RFA. Local eradication of metastasis from pancreatic duct adenocarcinoma (PADC) is more controversial. We aimed to investigate the feasibility and safety of EUS guided RFA in a highly selected group of patients with less than 4 liver metastases (LM).
PERFORMANCE OF P2/MS NON-INVASIVE INDEX IN THE PREDICTION OF HIGH-RISK ESOPHAGEAL VARICES
Authors: N. Trad, G. Mohamed, S. Bizid, I. Gamgami, B. Ben Slimane, K. Boughoula, H. Ben Abdallah, R. Bouali, M.N. Abdelli
Journal: Endoscopy (2022)

Aims Acute variceal bleeding is a life-threatening complication of portal hypertension. Our objective was to evaluate the performance of the P2/MS non-invasive index using complete blood counts in the prediction of high-risk esophageal varices (HRV).
Use of a Modified Preexposure Prophylaxis Vaccination Schedule to Prevent Human Rabies: Recommendations of the Advisory Committee on Immunization Practices — United States, 2022
Authors: Agam K. Rao, Deborah Briggs, Susan M. Moore, Florence Whitehill, Doug Campos-Outcalt, Rebecca L. Morgan, Ryan M. Wallace, José R. Romero, Lynn Bahta, Sharon E. Frey, Jesse D. Blanton
Journal: MMWR Morbidity and Mortality Weekly Report (2022)

Human rabies is an acute, progressive encephalomyelitis that is nearly always fatal once symptoms begin. Several measures have been implemented to prevent human rabies in the United States, including vaccination of targeted domesticated and wild animals, avoidance of behaviors that might precipitate an exposure (e.g., provoking high-risk animals), awareness of the types of animal contact that require postexposure prophylaxis (PEP), and use of proper personal protective equipment when handling animals or laboratory specimens. PEP is widely available in the United States and highly effective if administered after an exposure occurs. A small subset of persons has a higher level of risk for being exposed to rabies virus than does the general U.S. population; these persons are recommended to receive preexposure prophylaxis (PrEP), a series of human rabies vaccine doses administered before an exposure occurs, in addition to PEP after an exposure. PrEP does not eliminate the need for PEP; however, it does simplify the rabies PEP schedule (i.e., eliminates the need for rabies immunoglobulin and decreases the number of vaccine doses required for PEP). As rabies epidemiology has evolved and vaccine safety and efficacy have improved, Advisory Committee on Immunization Practices (ACIP) recommendations to prevent human rabies have changed. During September 2019-November 2021, the ACIP Rabies Work Group considered updates to the 2008 ACIP recommendations by evaluating newly published data, reviewing frequently asked questions, and identifying barriers to adherence to previous ACIP rabies vaccination recommendations. Topics were presented and discussed during six ACIP meetings. The following modifications to PrEP are summarized in this report: 1) redefined risk categories; 2) fewer vaccine doses in the primary vaccination schedule; 3) flexible options for ensuring long-term protection, or immunogenicity; 4) less frequent or no antibody titer checks for some risk groups; 5) a new minimum rabies antibody titer (0.5 international units [IUs]) per mL); and 6) clinical guidance, including for ensuring effective vaccination of certain special populations.
PERCUTANEOUS TRANSCYSTIC CHOLANGIOSCOPY-GUIDED ELECTROHYDRAULIC LITHOTRIPSY IN A PATIENT WITH ALTERED SURGICAL ANATOMY
Authors: J. Ferreira-Silva, E. Rodrigues-Pinto, P. Pereira, G. Macedo
Journal: Endoscopy (2022)

A 68-year-old man with history of distal gastrectomy underwent urgent cholecystectomy due to acute cholecystitis. Intraoperative choledochoscopy showed an unremovable common bile duct (CBD) stone; a transcystic nelaton tube was placed, with subsequent accidental displacement. As percutaneous biliary drainage persisted, percutaneous transcystic cholangioscopy-guided electrohydraulic lithotripsy was performed. Contrast instilled on percutaneous access confirmed persistence of the tract; guidewire passage into the CBD was achieved with contrast and single-operator cholangioscope assistance; cholangioscope passage was possible after dilatation of the proximal tract, with stone visualization in the distal CBD. Electrohydraulic lithotripsy was performed with stone pulverization. Patient remains well one month later.
EFFICACY OF ENDOSCOPIC PAPILLARY BALLOON DILATION AFTER SPHINCTEROTOMY FOR DIFFICULT BILE DUCT STONE CLEARANCE: A CASE-CONTROLLED STUDY
Authors: K. Amalou, F. Belghanem, M.T. Medkour, R. Rekab, N. Benboudiaf, M. Benachour, S. Kordjani, D. Kezoula
Journal: Endoscopy (2022)

Aims To evaluate the efficacy and safety of endoscopic sphincterotomy (EST)+endoscopic papillary large balloon dilation (EPLBD-s) vs isolated EST (iEST) for difficult bile duct stone clearance.
A CLINICALLY APPLICABLE, GENOMIC ASSAY DETECTS PATHOGENIC ALTERATIONS IN BARRETT’S ESOPHAGUS PATIENTS WITH NON-DYSPLASTIC TISSUE
Authors: N.F. Frei, A.M. Khoshiwal, G. Akarca, M. Rara, L.C. Duits, M. Hof, A. Zwinderman, C.-Z. Zhang, A.J. Bass, J.J. Bergman, M.D. Stachler
Journal: Endoscopy (2022)

Aims Current risk prediction for malignant progression in Barrett’s Esophagus (BE) is based on the histological diagnosis of dysplasia, which is limited by several factors. Genomic abnormalities precede dysplasia and may allow for objective and early risk stratification. We aimed to identify genomic factors to develop a clinically applicable targeted sequencing panel predicting progression in BE.
The dual role of autophagy in acute myeloid leukemia
Authors: Wonhyoung Seo, Prashanta Silwal, Ik-Chan Song, Eun-Kyeong Jo
Journal: Journal of Hematology & Oncology (2022)

Acute myeloid leukemia (AML) is a severe hematologic malignancy prevalent in older patients, and the identification of potential therapeutic targets for AML is problematic. Autophagy is a lysosome-dependent catabolic pathway involved in the tumorigenesis and/or treatment of various cancers. Mounting evidence has suggested that autophagy plays a critical role in the initiation and progression of AML and anticancer responses. In this review, we describe recent updates on the multifaceted functions of autophagy linking to genetic alterations of AML. We also summarize the latest evidence for autophagy-related genes as potential prognostic predictors and drivers of AML tumorigenesis. We then discuss the crosstalk between autophagy and tumor cell metabolism into the impact on both AML progression and anti-leukemic treatment. Moreover, a series of autophagy regulators, i.e., the inhibitors and activators, are described as potential therapeutics for AML. Finally, we describe the translation of autophagy-modulating therapeutics into clinical practice. Autophagy in AML is a double-edged sword, necessitating a deeper understanding of how autophagy influences dual functions in AML tumorigenesis and anti-leukemic responses.
THE ROLE OF THE ENDOSCOPIC DOPPLER PROBE IN NON VARICEAL UPPER GASTROINTESTINAL BLEEDING: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: N. Chapelle, M. Martel, M. Bardou, M. Almadi, A. Barkun
Journal: Endoscopy (2022)

Aims The effectiveness of the Doppler Endoscopic Probe (DEP) inserted through the operating channel in non-variceal upper gastrointestinal bleeding (NVUGIB). We aimed to perform a systematic review characterizing the effectiveness of DEP in patients with NVUGIB.
RNA-SEQUENCING OF PANCREATIC CANCER FROM EUS-ACQUIRED TISSUE IS USEFUL TO DEFINE MOLECULAR SUBTYPES AND PROGNOSIS
Authors: L. Archibugi, V. Ruta, V. Panzeri, P. Zaccari, M. Tacelli, M.C. Petrone, M. Falconi, M. Reni, C. Sette, P.G. Arcidiacono, G. Capurso
Journal: Endoscopy (2022)

Aims Pancreatic ductal adenocarcinoma (PDAC) is the 2nd leading cause of cancer-related mortality, with transcriptome subtypes related to different prognosis and chemotherapy response.
GASTRIC NEUROENDOCRINE TUMORS AND BIERMER'S ANEMIA: WHAT MANAGEMENT?
Authors: L. Nkurunziza, H. El Bacha, B. Bouibaouen, T. Gharbi, N. Benzzoubeir, I. Errabih
Journal: Endoscopy (2022)

Aims Gastric neuroendocrine tumors (GNT) are largely dominated by tumors derived from histamine-secreting enterochromaffin-like (ECL) cells located in the fundic mucosa. The majority of ECL cell tumours occur in the context of Biermer's disease.
PREDICTIVE FACTORS OF COMPLICATIONS IN COLORECTAL SUBMUCOSAL DISSECTION, A FRENCH TERTIARY CENTER EXPERIENCE
Authors: M. Vinson, J.-B. Chevaux, M. Schaefer, E. Albuisson, A. Belle, G. Gauchotte, A. Germain
Journal: Endoscopy (2022)

Aims Colorectal endoscopic submucosal dissection (ESD) is an innovative technique from Japan to resect superficial tumors without any size limit and avoid a complete monobloc resection. Colorectal ESD main complications are perforation, delayed bleeding and post electrocoagulation syndrome (PECS), appearing approximately in 10% of cases. This study aim was to define the incidence of colorectal ESD related complications and identify predictive factors of complications in a French tertiary center.
36P Young breast cancer biology explored by NanoString BC360 panel in a formalin-fixed paraffin-embedded cohort
Authors: L.M. Ingebriktsen, A.A. Svanøe, A.K.M. Sæle, K. Toska, M.B. Kalvenes, B. Davidsen, A. Heie, G. Knutsvik, I.M. Stefansson, L.A. Akslen, E. Wik
Journal: Annals of Oncology (2022)
Baricitinib in Alopecia Areata
Authors: Andrew Messenger, Matthew Harries
Journal: New England Journal of Medicine (2022)

For many people, alopecia areata is a transient problem, in which small patches of hair loss recover spontaneously within a few months. But for others, the reality is rather different. An Italian study showed that one third of patients with scalp hair loss of 25 to 50% still had active patchy disease at long-term follow-up, with a further third having progression to alopecia totalis or alopecia universalis, terms that vividly capture the extreme extent of disease and from which recovery is rare.1 For many patients with severe disease, medical treatments do not work, and they face difficulty in coping with . . .
INTRAGASTRIC BAND MIGRATION: AN UNCOMMON COMPLICATION
Authors: R. Muñoz González, A. Ezquerra Durán, E. Resina Sierra, C. Gómez Labrador, J.F. Prieto Aparicio, E. Fernández Velado, J. Mendoza Jiménez-Ridruejo, M.J. Casanova González, C. Santander, E. Rojo Aldama
Journal: Endoscopy (2022)

Laparoscopic adjustable gastric banding (LAGB) is a method of bariatric surgery with potential severe complications. A 41-year-old woman who underwent LAGB in 2009 presented with oral intolerance. An esophagogastroduodenoscopy showed a fibrotic stricture in the upper gastric body that was only overcome with a pediatric scope and the gastric band free in the antrum. In order to remove it, a partially covered metal stent was placed to dilate the stricture and two weeks later, an attempt was made to cut the band with SB knife, endoscopic scissors and polypectomy loop, without success. Finally, the patient required surgery for band removal.
PERCUTANEOUS CHOLANGIOSCOPY-GUIDED LITHOTRIPSY IN A PATIENT WITH OBSTRUCTIVE COMMON BILE DUCT STONES AFTER HEPATICOJEJUNOSTOMY
Authors: D. Costa, A. Tringali, G. Piccoli
Journal: Endoscopy (2022)

An 84-year-old female with hepaticojejunostomy presented with cholangitis due to obstructive common bile duct stones. Radiologic attempts to overcome the obstruction resulted unsuccessful. A 12 French introducer was then placed percutaneously through the left duct, leading the insertion of a dedicated single-operator cholangioscope. Electro-hydraulic lithotripsy was performed under direct visualisation until reaching the biliodigestive anastomosis. Stones fragments were pushed to the duodenum with a balloon. A guidewire was finally inserted through the cholangioscope in the duodenum, allowing the placement of an internal-external drainage.
ARGON PLASMA COAGULATION: IS IT SAFE WHEN MANAGED AS A HIGH BLEEDING RISK PROCEDURE?
Authors: M. João, A. Silva, S. Alves, S. Lopes, M. Areia, D. Brito, L. Elvas, S. Saraiva, P. Narra Figueiredo, A.T. Cadime
Journal: Endoscopy (2022)

Aims Argon plasma coagulation (APC) is an ablative therapy used for a wide variety of indications throughout the gastrointestinal tract. There are no data on continued use of antithrombotics with respect to the risk of bleeding after APC. Therefore, current ESGE guideline does not provide any guidance in this regard. This study aimed to assess post-procedure bleeding risk and to identify its risk factors.
Replication of Overall Survival, Progression-Free Survival, and Overall Response in Chemotherapy Arms of Non–Small Cell Lung Cancer Trials Using Real-World Data
Authors: Thanh G.N. Ton, Navdeep Pal, Huong Trinh, Sami Mahrus, Michael T. Bretscher, Robson J.M. Machado, Natalia Sadetsky, Nayan Chaudhary, Michael W. Lu, Gregory J. Riely
Journal: Clinical Cancer Research (2022)

Abstract Purpose: The utility of real-world data (RWD) for use as external controls in drug development is informed by studies that replicate trial control arms for different endpoints. The purpose of this study was to replicate control arms from four non–small cell lung cancer (NSCLC) randomized controlled trials (RCT) to analyze overall survival (OS), progression-free survival (PFS), and overall response rate (ORR) using RWD. Patients and Methods: This study used RWD from a nationwide de-identified database and a clinico-genomic database to replicate OS, PFS, and ORR endpoints in the chemotherapy control arms of four first-line NSCLC RCTs evaluating atezolizumab [IMpower150–wild-type (WT), IMpower130-WT, IMpower131, and IMpower132]. Additional objectives were to develop a definition of real-world PFS (rwPFS) and to evaluate the real-world response rate (rwRR) endpoint. Results: Baseline demographic and clinical characteristics were balanced after application of propensity score weighting methods. For rwPFS and OS, RWD external controls were generally similar to their RCT control counterparts. Across all four trials, the hazard ratio (HR) point estimates comparing trial controls with external controls were closer to 1.0 for the PFS endpoint than for the OS endpoint. An exploratory assessment of rwRR in RWD revealed a slight but nonsignificant overestimation of RCT ORR, which was unconfounded by baseline characteristics. Conclusions: RWD can be used to reasonably replicate the OS and PFS of chemotherapy control arms of first-line NSCLC RCTs. Additional studies can provide greater insight into the utility of RWD in drug development.
Effect of mycophenolate mofetil dose on antibody response following initial SARS-CoV-2 vaccination in patients with systemic sclerosis
Authors: Rachel Wallwork, Caoilfhionn M Connolly, Matthew Shneyderman, Zsuzsanna McMahan, Christopher A Mecoli, Fredrick Wigley, Laura K Hummers, Ami A Shah, Julie J Paik
Journal: The Lancet Rheumatology (2022)
ENDOSCOPIC ULTRASOUND- GUIDED FINE- NEEDLE BIOPSY USING A NEWLY DESIGNED NEEDLE WITH MULTI-BLADE THREE-PRONG TIP- INITIAL EXPERIENCE
Authors: P. Karagyozov, I. Zhecheva
Journal: Endoscopy (2022)

Aims To assess the performance of EUS-FNB using a new needle with multi-blade three-prong tip for the histologic diagnosis of lesions, accessible for endoscopic ultrasound- guided biopsy.
IGG4 ASSOCIATED MULTIFOCAL ULCERATING STENOSING ENTERITIS
Authors: L.E. Zamora Nava, C.L. Martinez-Garcia, F. Chable-Montero
Journal: Endoscopy (2022)

28 yo female with history of iron deficiency anemia with no gynecological causes and recurrent episodes of abdominal pain and bloating. Upper GI endoscopy and colonoscopy were performed without any significant findings. A videocapsule was performed showing congestive mucosa with ulcers, scares and zones of subestenosis at terminal ileum. A retrograde doble balloon enteroscopy was performed finding multiple areas of concentric irregular ulcers with secondary stenosis and scars were observed. Then a hydropneumatic dilation was performed without complications. The pathology report was consistent with IgG4 Associated Multifocal Ulcerating Stenosing Enteritis.
EARLY CHOLANGITIS AFTER BILIARY PLASTIC STENTING- ROOM TO IMPROVE. PRELIMINARY RESULTS FROM THE TEMPEST STUDY
Authors: B. Dinescu, G. Bajdechi, A. Bengus, T. Voiosu, C. Danielescu, B. Mateescu, R. Voiosu, A. Voiosu
Journal: Endoscopy (2022)

Aims Temporary plastic biliary stenting is widely used to ensure biliary drainage in various benign or malignant settings. Indwelling stents are however prone to complications generally arising from occlusion and bacterial colonization. We aim to identify procedure and patient-specific factors associated with early cholangitis.
OUTCOMES AND PREDICTIVE FACTORS OF SUBMUCOSAL FIBROSIS IN COLORECTAL ENDOSCOPIC SUBMUCOSAL DISSECTION: A PROSPECTIVE INTERNATIONAL STUDY
Authors: S. Sferrazza, F. Crispino, K. Motohiko, K. Yoshiyuki, J. Santos-Antunes, E. Tasini, A. Michielan, G. de Pretis, L. Frazzoni, L. Fuccio
Journal: Endoscopy (2022)

Aims Endoscopic submucosal dissection (ESD) enables en-bloc resection of large colorectal lesions. Submucosal fibrosis is a major feature for technical difficulty and poor outcomes. The aims of our study were: (1) to assess ESD outcomes according to the degree of fibrosis, and (2) to identify the predictive factors of fibrosis in colorectal lesions undergoing ESD.