tbuckley/cabot-search huggingface dataset:
Abstract 2935: Clinical-Instrumental Characteristics and Prognosis in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy: 30 Years of Experience in a Referral Center
Authors: Andrea Di Lenarda, Bruno Pinamonti, Marco Merlo, Alberto Pivetta, Stylianos Pyxaras, Andreea Dragos, Carmine Mazzone, Francesca Brun, Furio Silvestri, Gianfranco Sinagra
Journal: Circulation (2008)

There are few studies regarding the clinical and instrumental presentation of Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC); all available data derive from few specialized centers. We sought to describe clinical characteristics, instrumental findings and prognosis in a large cohort of patients (pts) with an ARVC diagnosis. From 1976 to 2006 all pts matching ARVC diagnostic criteria were enrolled in the Heart Muscle Disease Registry of Trieste and underwent a structured diagnostic protocol and follow-up. 104 pts were studied, 66% males, mean age 33±13 years; 84% were symptomatic at enrolment (mean duration 44±67 months); 75% had symptomatic arrhythmias (43% with previous sustained ventricular tachycardia or ventricular fibrillation (SVT/VF)), 36% syncope, 20% heart failure (12% in NYHA class III-IV). Familial ARVC were present in 46% of pts. ECG was abnormal in 72% (right bundle branch block 25%; epsilon potentials 15%; anterior negative T waves 51%; QRS dispersion &gt;40ms 11%). At signal averaged ECG late potentials were present in 58% of pts. At 2D echo, mean right ventricle (RV) end-diastolic area was 30± 8 cm2 and RV fractional area contraction (FAC) 30±13%; RV aneurysms were present in 67%. RV systolic dysfunction (defined as FAC&lt;40%) was present in 78%, characterized severe (FAC &lt;30%) in 48%. Left ventricular systolic dysfunction was present in 27% of pts. Stress test was interrupted in 11% of cases for ventricular arrhythmias (55% SVT/VF). RV fibrofatty tissue was present in 52% of Nuclear Magnetic Resonance and in 59% of RV endomyocardial biopsy (performed respectively in 24 and 27% of pts). During a mean follow-up of 132±89 months, 3 pts were lost; 20 out of the remaining 101 pts (20%) experienced death/heart transplantation, 6 (3%) died for refractory HF; 4 pts (2%) underwent heart transplantation (HT); 6 pts (3%) died suddenly; one (0.5%) for extracardiac disease and 3 (1.6%) for unknown reason. Ten-year cumulative survival free from HT was 57%. In our population ARVC presentation was characterized by symptomatic, frequently sustained ventricular arrhythmias. Notably, LV involvement was present in approximately one third of pts at enrolment. In the long term, the overall prognosis was severe.
Abstract PO-038: Hide and Seq: Radiation-induced immunogenicity of patient tumors revealed by single cell analysis
Authors: Jacky L. Chow, Nicholas Hoffend, Madeline Gaudieri, Scott Abrams, Thomas Schwaab, Anurag Singh, Jason Muhitch
Journal: Clinical Cancer Research (2021)

Abstract Robust preclinical investigations into radiation-induced immunogenicity has led to increased enthusiasm for combining radiation with immunotherapy. Promising results in a limited number of patients treated with radiotherapy and immune-activating strategies has supported the initiation of over 150 ongoing clinical trials. Yet, due to reduced availability of patient samples following treatment, tumor tissue in particular, there has been sparse investigation of the impact of radiation on immunogenicity in human malignancies. While murine models have revealed important insights into understanding radiation-induced immunogenic mechanisms, inherent differences in radiation sensitivity between mice and humans limit translation to patients. To determine the impact of radiation on patient tumor cells we analyzed samples from renal cell carcinoma (RCC) patients treated with stereotactic body radiation therapy (SBRT) in a pilot study (NCT01892930). Previous data showed radiation induced surface presentation of tumor-associated antigens in resected irradiated tumors. Bulk transcriptomic data of in situ-irradiated tumors showed evidence of immune activation, including increased interferon-gamma (IFNG) signaling, as well as increased T cell clonality and higher abundance of T cells clones with similar binding affinities predicted by dominant motif analysis. We hypothesized that the tumor response to in situ irradiation included increased transcript abundance for tumor antigen genes and antigen-presentation machinery, as well as a response to IFNG signaling. Tumor cell comparisons following single-cell RNA sequencing uncovered RCC cell-specific responses to in situ irradiation. Irradiated RCC tumor cells expressed higher levels of genes encoding MUC-1 and carbonic anhydrase 9, as well as higher expression of calreticulin and genes encoding MHC class 1 molecules: HLA-A, HLA-B, and HLA-C; furthermore, gene set enrichment identified enhancement of antigen processing and presentation pathways. Additionally, irradiated tumor cells expressed higher levels of the IFNG receptor, its downstream targets, and the enrichment of several interferon response gene sets. Collectively, these results indicate radiation may improve tumor recognition through both increased antigen expression and surface presentation as well as sensitize tumor cells to immunogenic cytokines and T cell-mediated cytolysis in human malignancies, such as RCC. Citation Format: Jacky L. Chow, Nicholas Hoffend, Madeline Gaudieri, Scott Abrams, Thomas Schwaab, Anurag Singh, Jason Muhitch. Hide and Seq: Radiation-induced immunogenicity of patient tumors revealed by single cell analysis [abstract]. In: Proceedings of the AACR Virtual Special Conference on Radiation Science and Medicine; 2021 Mar 2-3. Philadelphia (PA): AACR; Clin Cancer Res 2021;27(8_Suppl):Abstract nr PO-038.
Secreted Extracellular Cyclophilin A Is a Novel Mediator of Ventilator-induced Lung Injury
Authors: Marissa W. Koh, Rhianna F. Baldi, Sanooj Soni, Rhodri Handslip, Ying Ying Tan, Kieran P. O’Dea, Miroslav Malesevic, Daniel F. McAuley, Cecilia M. O’Kane, Brijesh V. Patel, Masao Takata, Michael R. Wilson
Journal: American Journal of Respiratory and Critical Care Medicine (2021)

Mechanical ventilation is a mainstay of intensive care but contributes to the mortality of patients through ventilator-induced lung injury. eCypA (extracellular CypA [cyclophilin A]) is an emerging inflammatory mediator and metalloproteinase inducer, and the gene responsible for its expression has recently been linked to coronavirus disease (COVID-19).
Electronic Cigarette Use and Cigarette-Smoking Cessation Attempts Among Stroke Survivors in the US
Authors: Neal S. Parikh, Babak B. Navi, Alexander E. Merkler, Hooman Kamel
Journal: JAMA Neurology (2021)

This cross-sectional study estimates the prevalence of electronic cigarette use among actively smoking stroke survivors in the US and evaluates its association with at least 1 cigarette-smoking cessation attempt in the past year.
Fibrous Dysplasia Mimicking Skeletal Metastasis on 68Ga-FAPI PET Imaging
Authors: Yangmeihui Song, Chunxia Qin, Fang Liu, Xiaoli Lan
Journal: Clinical Nuclear Medicine (2021)

68Ga-labeled fibroblast activation protein inhibitor (68Ga-FAPI) PET imaging has been introduced for detecting many primary and metastatic tumors. However, false-positive uptakes have been reported in some benign lesions. Here, we presented a 68Ga-FAPI-avid lesion in the left temporal bone in a 41-year-old man with a history of signet ring cell gastric adenocarcinoma. The osseous lesion was finally distinguished as fibrous dysplasia according to the clinical and imaging findings. This case suggests that 68Ga-FAPI may have false-positive uptakes in bone benign lesions, which should be paid attention to in the diagnosis of bone lesions in patients with malignant tumors.
Legislation restricting access to public restrooms and changing facilities for transgender individuals in Texas (US): A qualitative analysis of testimony
Authors: Aren E. Kurth, Jae. A. Puckett, Kaston D. Anderson-Carpenter
Journal: International Journal of Transgender Health (2021)

An alarming amount of legislation in the United States has sought to restrict the rights of transgender people, often targeting access to public spaces or restrooms. One example of this legislation is the Texas Privacy Act (Senate Bill 6; 2017), which detailed "regulations and policies for entering or using a bathroom or changing facility" (Texas Legislature Online).Aims: The hearing for SB 6 included over 18 hours of public testimony, which we analyzed to better understand arguments for and against this bill.Methods: We conducted a thematic analysis of this public testimony.Results: Supporters of SB 6 frequently framed their arguments in terms of safety and security, economic impact, and privacy and dignity. Those opposing SB 6 focused on discrimination, safety and security, and the effects of transgender people being forced into the wrong facilities.Discussion: These findings can aid in understanding education that may help to combat viewpoints that lead to passing such legislation and contributes to understanding how legal policies shape views of gender.
Biomarker-Based Risk Prediction With the ABC-AF Scores in Patients With Atrial Fibrillation Not Receiving Oral Anticoagulation
Authors: Alexander P. Benz, Ziad Hijazi, Johan Lindbäck, Stuart J. Connolly, John W. Eikelboom, Jonas Oldgren, Agneta Siegbahn, Lars Wallentin
Journal: Circulation (2021)

Background: The novel ABC (Age, Biomarkers, Clinical History) scores outperform traditional risk scores for stroke, major bleeding, and death in patients with atrial fibrillation (AF) receiving oral anticoagulation. To refine their utility, the ABC-AF scores needed to be validated in patients not receiving oral anticoagulation. Methods: We measured plasma levels of the ABC biomarkers (N-terminal pro-B-type natriuretic peptide, cardiac troponin-T, and growth-differentiation factor 15) to apply the previously developed ABC-AF scores in patients with AF receiving aspirin (n=3195) or aspirin and clopidogrel (n=1110) in 2 large clinical trials. Calibration was assessed by comparing estimated with observed 1-year risks. Cox regression models were used for recalibration. Discrimination was evaluated separately for the aspirin-only and the overall cohort (n=4305). Results: The ABC-AF-stroke score yielded a c-index of 0.70 (95% CI, 0.67–0.73) in both cohorts. The ABC-AF-bleeding score had a c-index of 0.76 (95% CI, 0.71–0.81) in the aspirin-only cohort and 0.73 (95% CI, 0.69–0.77) overall. Both scores were superior to risk scores recommended by current guidelines. The ABC-AF-death score yielded a c-index of 0.78 (95% CI, 0.76–0.80) overall. Calibrated in patients receiving oral anticoagulation, the ABC-AF-stroke score underestimated and the ABC-AF-bleeding score overestimated the risk of events in both cohorts. These scores were recalibrated for prediction of absolute event rates in the absence of oral anticoagulation. Conclusions: The biomarker-based ABC-AF scores showed better discrimination than traditional risk scores and were recalibrated for precise risk estimation in patients not receiving oral anticoagulation. They can now provide improved decision support on treatment of an individual patient with AF.
A Collision Intrathyroidal Tumor Causing Primary Hyperparathyroidism
Authors: Luca Foppiani, Simona Sola, Francesca Pitto, Gianluca Ansaldo, Arnoldo Piccardo
Journal: Clinical Nuclear Medicine (2021)

Abstract A 67-year-old man was diagnosed with primary hyperparathyroidism and normofunctioning left nodular goiter. Fine-needle aspiration cytology showed thyroid (Thy) 4 (suspicious of malignancy). After first-line imaging proved negative, integrated 18 F-choline PET/4D contrast-enhanced CT revealed uptake by the thyroid nodule and by 3 nodules of the left central compartment. Thyroidectomy and lymphadenectomy were performed. Histopathology revealed a collision tumor (ie, 2 histologically distinct tumors occurring at the same anatomic site) composed of both PTC (papillary thyroid carcinoma) and parathyroid carcinoma within the left thyroid nodule. Lymph nodes showed PTC metastases. Primary hyperparathyroidism and calcium levels normalized, and the patient underwent radioiodine therapy.
Implant Surface Texture and Breast Cancer Recurrence
Authors: Wiesje Maarse, Teun Teunis
Journal: JAMA Surgery (2021)

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Epigenetic association studies at birth and the origin of lung function development
Authors: Marta Cosín-Tomás, Mariona Bustamante, Jordi Sunyer
Journal: European Respiratory Journal (2021)

<b>Mukherjee and co-workers explore for the first time the association between blood DNA methylation patterns at birth and lung function trajectories from childhood to adulthood. The beneficial implications of this kind of research are promising.</b>https://bit.ly/3qlytda
Workers’ Compensation Claim Rates and Costs for Musculoskeletal Disorders Related to Overexertion Among Construction Workers — Ohio, 2007–2017
Authors: Harpriya Kaur, Steven J. Wurzelbacher, P. Tim Bushnell, James W. Grosch, Chih-Yu Tseng, Juliann C. Scholl, Alysha R. Meyers, Michael Lampl
Journal: MMWR Morbidity and Mortality Weekly Report (2021)

Overexertion is a leading cause of work-related musculoskeletal disorders (WMSDs) among construction workers. Nearly 90% of construction jobs require manual handling of materials for approximately one half of the worker's time (1). In 2015, overexertion from lifting and lowering materials caused 30% of WMSDs among construction workers; overexertion involving pushing, pulling, holding, carrying, and catching materials caused an additional 37% of WMSDs (1). This study examined the rate and cost of WMSD claims from overexertion among Ohio construction workers during 2007-2017. Workers' compensation claims related to overexertion that were submitted to the Ohio Bureau of Worker's Compensation (OHBWC) by workers in the construction industry for injuries and illnesses occurring during 2007-2017 were analyzed. Rates and costs of allowed claims were measured by age group. Workers aged 35-44 years experienced the highest claim rate: 63 per 10,000 full-time employees (FTEs) for WMSDs from overexertion. However, claims by workers aged 45-54 years and 55-64 years were more costly on average and resulted in more days away from work. Ergonomic design improvements and interventions are needed to ensure that the majority of construction workers can safely perform jobs throughout their careers. Age-specific WMSD prevention and risk communication efforts also might be helpful.
Why USPSTF Still Finds Insufficient Evidence to Support Screening for Vitamin D Deficiency
Authors: Erin D. Michos, Rita R. Kalyani, Jodi B. Segal
Journal: JAMA Network Open (2021)

US Preventive Services Task Force; Alex H. Krist, MD, MPH; Karina W. Davidson, PhD, MASc; Carol M. Mangione, MD, MSPH; Michael Cabana, MD, MA, MPH; Aaron B. Caughey, MD, PhD; Esa M. Davis, MD, MPH; Katrina E. Donahue, MD, MPH; Chyke A. Doubeni, MD, MPH; John W. Epling Jr, MD, MSEd; Martha Kubik, PhD, RN; Li Li, MD, PhD, MPH; Gbenga Ogedegbe, MD, MPH; Douglas K. Owens, MD, MS; Lori Pbert, PhD; Michael Silverstein, MD, MPH; James Stevermer, MD, MSPH; Chien-Wen Tseng, MD, MPH, MSEE; John B. Wong, MD
Development and content validation of the Safe Surgery Organizational Readiness Tool: A quality improvement study
Authors: Tuna C. Hayirli, John G. Meara, David Barash, Bwire Chirangi, Augustino Hellar, Benard Kenemo, Innocent Kissima, Sarah Maongezi, Cheri Reynolds, Hendry Samky, Mpoki Ulisubisya, John E. Varallo, Chloe B. Warinner, Shehnaz Alidina, Ntuli A. Kapologwe
Journal: International Journal of Surgery (2021)

Recent efforts to increase access to safe and high-quality surgical care in low- and middle-income countries have proven successful. However, multiple facilities implementing the same safety and quality improvement interventions may not all achieve successful outcomes. This heterogeneity could be explained, in part, by pre-intervention organizational characteristics and lack of readiness of surgical facilities. In this study, we describe the process of developing and content validating the Safe Surgery Organizational Readiness Tool.The new tool was developed in two stages. First, qualitative results from a Safe Surgery 2020 intervention were combined with findings from a literature review of organizational readiness and change. Second, through iterative discussions and expert review, the Safe Surgery Organizational Readiness Tool was content validated.The Safe Surgery Organizational Readiness Tool includes 14 domains and 56 items measuring the readiness of surgical facilities in low- and middle-income countries to implement surgical safety and quality improvement interventions. This multi-dimensional and multi-level tool offers insights into facility members' beliefs and attitudes at the individual, team, and facility levels. A panel review affirmed the content validity of the Safe Surgery Organizational Readiness Tool.The Safe Surgery Organizational Readiness Tool is a theory- and evidence-based tool that can be used by change agents and facility leaders in low- and middle-income countries to assess the baseline readiness of surgical facilities to implement surgical safety and quality improvement interventions. Next steps include assessing the reliability and validity of the Safe Surgery Organizational Readiness Tool, likely resulting in refinements.
Protein Mannosylation as a Diagnostic and Prognostic Biomarker of Lupus Nephritis: An Unusual Glycan Neoepitope in Systemic Lupus Erythematosus
Authors: Inês Alves, Beatriz Santos‐Pereira, Hans Dalebout, Sofia Santos, Manuel M. Vicente, Ana Campar, Michel Thepaut, Franck Fieschi, Sabine Strahl, Fanny Boyaval, Ramon Vizcaíno, Roberto Silva, Stephanie Holst‐Bernal, Carlos Vasconcelos, Lélita Santos, Manfred Wuhrer, António Marinho, Bram Heijs, Salomé S. Pinho
Journal: Arthritis & Rheumatology (2021)

Changes in protein glycosylation are a hallmark of immune-mediated diseases. Glycans are master regulators of the inflammatory response and are important molecules in self-nonself discrimination. This study was undertaken to investigate whether lupus nephritis (LN) exhibits altered cellular glycosylation to identify a unique glycosignature that characterizes LN pathogenesis.A comprehensive tissue glycomics characterization was performed in kidney specimens from patients with systemic lupus erythematosus and biopsy-proven LN. A combination of advanced tissue mass spectrometry, in situ glyco-characterization, and ex vivo glycophenotyping was performed to structurally map the repertoire of N-glycans in LN tissue samples.LN exhibited a unique glycan signature characterized by increased abundance and spatial distribution of unusual mannose-enriched glycans that are typically found in lower microorganisms. This glycosignature was specific for LN, as it was not observed in other kidney diseases. Exposure of mannosylated glycans in LN was shown to occur at the cell surface of kidney cells, promoting increased recognition by specific glycan-recognizing receptors expressed by immune cells. This abnormal glycosignature of LN was shown to be due to a deficient complex N-glycosylation pathway and a proficient O-mannosylation pathway. Moreover, mannosylation levels detected in kidney biopsy samples from patients with LN at the time of diagnosis were demonstrated to predict the development of chronic kidney disease (CKD) with 93% specificity.Cellular mannosylation is a marker of LN, predicting the development of CKD, and thus representing a potential glycobiomarker to be included in the diagnostic and prognostic algorithm of LN.
Real‐world experience of off‐label use of imiquimod 5% as an adjuvant therapy after surgery or as a monotherapy for lentigo maligna
Authors: A. Lallas, E. Moscarella, H. Kittler, C. Longo, L. Thomas, I. Zalaudek, A. Kyrgidis, S.M. Manoli, N. Meo, C. Papageorgiou, Z. Apalla, G. Argenziano
Journal: British Journal of Dermatology (2021)

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Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054): distant metastasis-free survival results from a double-blind, randomised, controlled, phase 3 trial
Authors: Alexander M M Eggermont, Christian U Blank, Mario Mandalà, Georgina V Long, Victoria G Atkinson, Stéphane Dalle, Andrew M Haydon, Andrey Meshcheryakov, Adnan Khattak, Matteo S Carlino, Shahneen Sandhu, James Larkin, Susana Puig, Paolo A Ascierto, Piotr Rutkowski, Dirk Schadendorf, Rutger Koornstra, Leonel Hernandez-Aya, Anna Maria Di Giacomo, Alfonsus J M van den Eertwegh, Jean-Jacques Grob, Ralf Gutzmer, Rahima Jamal, Paul C Lorigan, Alexander C J van Akkooi, Clemens Krepler, Nageatte Ibrahim, Sandrine Marreaud, Michal Kicinski, Stefan Suciu, Caroline Robert, Alex Menzies, Thierry Lesimple, Michele Maio, Gerald Linette, Michael Brown, Peter Hersey, Inge Marie Svane, Laurent Mortier, Jacob Schachter, Catherine Barrow, Ragini Kudchadkar, Xinni Song, Caroline Dutriaux, Pietro Quaglino, Friedegund Meier, Paola Queirolo, Daniil Stroyakovskiy, Lars Bastholt, Bernard Guillot, Claus Garbe, Pablo Luis Ortiz Romero, Florent Grange, Peter Mohr, Alain Algazi, Oliver Bechter, Micaela Hernberg, Jean-Philippe Arnault, Philippe Saiag, Carmen Loquai, Frank Meiss, Jan-Christoph Simon, Gil Bar-Sela, Vanna Chiarion Sileni, Bernard Fitzharris, Mike McCrystal, Phillip Parente, Jean-Francois Baurain, Patrick Combemale, Célèste Lebbe, Axel Hauschild, Naoya Yamazaki, Reinhard Dummer, Mohammed Milhem, Marcin Dzienis, John Walker, Lionel Geoffrois, Marie-Thérèse Leccia, Lutz Kretschmer, Daniel Hendler, Michal Lotem, Andrzej Mackiewicz, Lidija Sekulovic, Elaine Dunwoodie, Christoph Hoeller, Laurent Machet, Jessica Hassel, Geke A.P. Hospers, Maria-Jose Passos, Max Levin, Martin Fehr, Philippa Corrie, Ashita Waterston, Sigrun Hallmeyer, Henrik Schmidt, Vincent Descamps, Jean-Philippe Lacour, Carola Berking, Felix Kiecker, Pier Francesco Ferrucci, Kenji Yokota, Maureen Aarts, Michael Jameson, Anna Katharina Winge-Main, Paula Ferreira, Kevin Kim, Catriona McNeil, Reiner Hofmann-Wellenhof, Joseph Kerger, François Aubin, Jochen Utikal, Virginia Ferraresi, Takashi Inozume, Yoshio Kiyohara, Gerard Groenewegen, Helena Kapiteijn, Suzana Matkovic, Wolf-Henning Boehncke, Richard Casasola, Timothy Crook, Ernest Marshall, Tanja Skytta, Marie-Francoise Avril, Thomas Jouary, Rüdiger Hein, Patrick Terheyden, Jun Aoi, Tatsuya Takenouchi, Oddbjorn Straume, César Martins, Guzel Mukhametshina, Paul Nathan
Journal: The Lancet Oncology (2021)