tbuckley/cabot-search huggingface dataset:
Randomized Controlled Phase II Evaluation of Two Dose Levels of Bupropion Versus Placebo for Sexual Desire in Female Cancer Survivors: NRG-CC004
Authors: Debra L. Barton, Stephanie L. Pugh, Patricia A. Ganz, Steven C. Plaxe, Bridget F. Koontz, Jeanne Carter, Natalya Greyz-Yusupov, Seth J. Page, Kendrith M. Rowland, Ernie P. Balcueva, Sobia Nabeel, Jack B. Basil, Matthew L. Hill, Carolyn Y. Muller, Maria C. Bell, Snehal Deshmukh, Lisa A. Kachnic
Journal: Journal of Clinical Oncology (2021)

Because of the negative impact of cancer treatment on female sexual function, effective treatments are warranted. The purpose of this multisite study was to evaluate the ability of two dose levels of extended-release bupropion, a dopaminergic agent, to improve sexual desire more than placebo at 9 weeks, measured by the desire subscale of the Female Sexual Function Index (FSFI), and to evaluate associated toxicities.Postmenopausal women diagnosed with breast or gynecologic cancer and low baseline FSFI desire scores (< 3.3), who had completed definitive cancer therapy, were eligible. Women were randomly assigned to receive 150 mg or 300 mg once daily of extended-release bupropion or a matching placebo. t-tests were performed on the FSFI desire subscale to evaluate whether there was a significantly greater change from baseline to 9 weeks between placebo and each bupropion arm as the primary end point. Sixty-two patients per arm provided 80% power using a one-sided t-test.Two hundred thirty women were randomly assigned from 72 institutions through the NRG Oncology NCORP network. At 9 weeks, there were no statistically significant differences in change of the desire subscale scores between groups; participants in all three arms reported improvement. The mean changes for each arm were placebo 0.62 (standard deviation [SD] = 1.18), 150-mg once daily bupropion 0.64 (SD = 0.95), and 300-mg once daily bupropion 0.60 (SD = 0.89). Total and subscale scores on the FSFI were low throughout the study, indicating dysfunction in all groups.Bupropion was not more effective than placebo in improving the desire subscale of the FSFI. Subscale and total scores of the FSFI demonstrated dysfunction throughout the 9 weeks of the study. More research is needed to support sexual function in female cancer survivors.
The Difficulties of Diagnosing Tumor of the Ewing’s Family of Sarcomas in an Emergency Hospital (Clinical Observation)
Authors: A. Yu. Vasil’ev, T. V. Pavlova, V. A. Nechaev, Z. N. Baratashvili, O. O. Manuylova
Journal: Radiology - Practice (2021)

The author presents his own clinical case demonstrating the long stage and difficulties in diagnosing a rare tumor of the Ewing’s Family of Sarcomas in a young patient, due to the peculiarity of the course of the disease, manifested by a non-pathognomonic clinical pattern.
Error in Abstract
Journal: JAMA Network Open (2021)

Guneet K. Jasuja, PhD, MPH; Mark Meterko, PhD; Ledjona D. Bradshaw, MPH; Richard Carbonaro, PhD; Marla L. Clayman, PhD, MPH; Lara LoBrutto, MPH; Danielle Miano, BA; Elizabeth M. Maguire, MSW; Amanda M. Midboe, PhD; Steven M. Asch, MD, MPH; Allen L. Gifford, MD; D. Keith McInnes, ScD, MS; A. Rani Elwy, PhD
Wireless Force‐Inducing Neuronal Stimulation Mediated by High Magnetic Moment Microdiscs
Authors: Claudia Collier, Nicolas Muzzio, Rohini Thevi Guntnur, Amanda Gomez, Carolina Redondo, Raquel Zurbano, Ivan K. Schuller, Carlos Monton, Rafael Morales, Gabriela Romero
Journal: Advanced Healthcare Materials (2021)

Noninvasive manipulation of cell signaling is critical in basic neuroscience research and in developing therapies for neurological disorders and psychiatric conditions. Here, the wireless force-induced stimulation of primary neuronal circuits through mechanotransduction mediated by magnetic microdiscs (MMDs) under applied low-intensity and low-frequency alternating magnetic fields (AMFs), is described. MMDs are fabricated by top-down lithography techniques that allow for cost-effective mass production of biocompatible MMDs with high saturation and zero magnetic magnetic moment at remanence. MMDs are utilized as transducers of AMFs into mechanical forces. When MMDs are exposed to primary rat neuronal circuits, their magneto-mechanical actuation triggers the response of specific mechanosensitive ion channels expressed on the cell membranes activating ≈50% of hippocampal and ≈90% of cortical neurons subjected to the treatment. Mechanotransduction is confirmed by the inhibition of mechanosensitive transmembrane channels with Gd
Obstructive Sleep Apnea Symptom Subtypes and Cardiovascular Risk: Conflicting Evidence to an Important Question
Authors: Brendan T. Keenan, Ulysses J. Magalang, Diego R. Mazzotti, Nigel McArdle, Thorarinn Gislason, Bhajan Singh, Greg Maislin, Allan I. Pack
Journal: American Journal of Respiratory and Critical Care Medicine (2021)

12:00 in our patients with COPD are also compatible with aggregated data from healthy subjects and those with asthma, which indicated a peak value around 4:00 and a trough value between 10:00 and 16:00 (7, 8).The high proportion (50%) of patients with COPD crossing GOLD thresholds during the day can be related to previous COPD studies of BEC stability over much longer time periods (4, 9), bearing in mind that crossing thresholds is a relatively crude measure.When examining the same three categories of less than 100, 100-299, and 300 or more eosinophils/μl (as we have done here), only 31% of the patients with COPD were found to cross into another category over 1 year (9).This could suggest that BEC data in Long and colleagues (9) had probably been gathered at the same time of day to avoid the within-day BEC variability we observed here.In any case, future long-term follow-up studies with BEC as a biomarker would surely benefit from same time of day measurement, owing to the diurnal BEC variations now demonstrated in patients with COPD.Such studies should also be standardized for potential technical sources of variability of BEC measurement as outlined by Chipps and colleagues (10).A study limitation is sample size, as is usually the case in studies requiring the patients to remain available for repeated blood sampling.However, observed patterns were very consistent even in this relatively small group, and despite being obtained in the real-life setting of the outpatient clinic.We demonstrated significant within-day differences in blood eosinophils in stable patients with COPD with a consistent underlying pattern.Ideally, BEC could be improved as a theragnostic biomarker by reaching a consensus on the time of day of blood sampling.This may not be workable in the reality of the clinic, in which case at least the same time of day should be considered for the follow-up of any given patient.
Gatekeepers, wizards, and a mutual appreciation of each other’s kingdoms
Authors: Pritti Aggarwal, Harnish P Patel
Journal: BMJ (2021)

Collaborative working is crucial to providing joined up, high quality care, yet medicine continues to be a divided profession of gatekeepers (GPs) and wizards (specialists). 1 2 The covid-19 pandemic has exacerbated this sense of estrangement, with ever increasing workloads not conducive to goodwill across healthcare teams.More than ever, we need to create a shared understanding of each other's roles and ignite opportunities for interprofessional education and communication.We both participated in a GP-consultant exchange scheme just before the pandemic 3 and share how it's shaped our perception of each other's work and our practice.
The influence of nanotopography on cell behaviour through interactions with the extracellular matrix – A review
Authors: Jiajun Luo, Matthew Walker, Yinbo Xiao, Hannah Donnelly, Matthew J. Dalby, Manuel Salmeron-Sanchez
Journal: Bioactive Materials (2021)

Nanotopography presents an effective physical approach for biomaterial cell manipulation mediated through material-extracellular matrix interactions. The extracellular matrix that exists in the cellular microenvironment is crucial for guiding cell behaviours, such as determination of integrin ligation and interaction with growth factors. These interactions with the extracellular matrix regulate downstream mechanotransductive pathways, such as rearrangements in the cytoskeleton and activation of signal cascades. Protein adsorption onto nanotopography strongly influences the conformation and distribution density of extracellular matrix and, therefore, subsequent cell responses. In this review, we first discuss the interactive mechanisms of protein physical adsorption on nanotopography. Secondly, we summarise advances in creating nanotopographical features to instruct desired cell behaviours. Lastly, we focus on the cellular mechanotransductive pathways initiated by nanotopography. This review provides an overview of the current state-of-the-art designs of nanotopography aiming to provide better biomedical materials for the future.
NCCN Guidelines® Insights: Squamous Cell Skin Cancer, Version 1.2022
Authors: Chrysalyne D. Schmults, Rachel Blitzblau, Sumaira Z. Aasi, Murad Alam, James S. Andersen, Brian C. Baumann, Jeremy Bordeaux, Pei-Ling Chen, Robert Chin, Carlo M. Contreras, Dominick DiMaio, Jessica M. Donigan, Jeffrey M. Farma, Karthik Ghosh, Roy C. Grekin, Kelly Harms, Alan L. Ho, Ashley Holder, John Nicholas Lukens, Theresa Medina, Kishwer S. Nehal, Paul Nghiem, Soo Park, Tejesh Patel, Igor Puzanov, Jeffrey Scott, Aleksandar Sekulic, Ashok R. Shaha, Divya Srivastava, William Stebbins, Valencia Thomas, Yaohui G. Xu, Beth McCullough, Mary A. Dwyer, Mai Q. Nguyen
Journal: Journal of the National Comprehensive Cancer Network (2021)

The NCCN Guidelines for Squamous Cell Skin Cancer provide recommendations for diagnostic workup, clinical stage, and treatment options for patients with cutaneous squamous cell carcinoma. The NCCN panel meets annually to discuss updates to the guidelines based on comments from panel members and the Institutional Review, as well as submissions from within NCCN and external organizations. These NCCN Guidelines Insights focus on the introduction of a new surgical recommendation terminology (peripheral and deep en face margin assessment), as well as recent updates on topical prophylaxis, immunotherapy for regional and metastatic disease, and radiation therapy.
Error in Figure 3
Journal: JAMA Network Open (2021)

The OSCIS investigators; Hirotaka Chikuda, MD, PhD; Yurie Koyama, RN, PhD; Yoshitaka Matsubayashi, MD; Toru Ogata, MD, PhD; Hiroshi Ohtsu, MS; Shurei Sugita, MD, PhD; Masahiko Sumitani, MD, PhD; Yuho Kadono, MD, PhD; Toshiki Miura, MD, PhD; Sakae Tanaka, MD, PhD; Toru Akiyama, MD, PhD; Kei Ando, MD, PhD; Masato Anno, MD, MPH; Seiichi Azuma, MD; Kenji Endo, MD, PhD; Toru Endo, MD; Takayuki Fujiyoshi, MD, PhD; Takeo Furuya, MD, PhD; Hiroyuki Hayashi, MD, PhD; Akiro Higashikawa, MD, PhD; Akihiko Hiyama, MD, PhD; Chiaki Horii, MD; Seiji Iimoto, MD, PhD; Yoichi Iizuka, MD, PhD; Hisanori Ikuma, MD, PhD; Shiro Imagama, MD, PhD; Koichi Inokuchi, MD, PhD; Hirokazu Inoue, MD, PhD; Tomoo Inoue, MD; Keisuke Ishii, MD; Masayoshi Ishii, MD; Takui Ito, MD, PhD; Akira Itoi, MD, MPH; Kohei Iwamoto, MD; Motoki Iwasaki, MD, PhD; Takashi Kaito, MD, PhD; Tsuyoshi Kato, MD, PhD; Hiroyuki Katoh, MD, PhD; Yoshiharu Kawaguchi, MD, PhD; Osamu Kawano, MD, PhD; Atsushi Kimura, MD, PhD; Kazuyoshi Kobayashi, MD, PhD; Masao Koda, MD, PhD; Miki Komatsu, MD, PhD; Gentaro Kumagai, MD, PhD; Takeshi Maeda, MD, PhD; Takahiro Makino, MD; Chikato Mannoji, MD, PhD; Kazuhiro Masuda, MD; Keisuke Masuda, MD, PhD; Koji Matsumoto, MD, PhD; Morio Matsumoto, MD, PhD; Shunji Matsunaga, MD, PhD; Yukihiro Matsuyama, MD, PhD; Tokue Mieda, MD, PhD; Kota Miyoshi, MD, PhD; Joji Mochida, MD, PhD; Hiroshi Moridaira, MD, PhD; Hiroyuki Motegi, MD, PhD; Yukihiro Nakagawa, MD, PhD; Yutaka Nohara, MD, PhD; Kazunori Oae, MD, PhD; Shinji Ogawa, MD; Rentaro Okazaki, MD, PhD; Akinori Okuda, MD, PhD; Eijiro Onishi, MD, PhD; Atsushi Ono, MD, PhD; Masashi Oshima, MD, PhD; Yusuke Oshita, MD, PhD; Kazuo Saita, MD, PhD; Yutaka Sasao, MD, PhD; Kimiaki Sato, MD, PhD; Kimihiko Sawakami, MD, PhD; Atsushi Seichi, MD, PhD; Shoji Seki, MD, PhD; Hideki Shigematsu, MD, PhD; Kota Suda, MD, PhD; Yasutaka Takagi, MD, PhD; Masahito Takahashi, MD, PhD; Ryosuke Takahashi, MD; Eiji Takasawa, MD, PhD; Shota Takenaka, MD; Katsushi Takeshita, MD, PhD; Yujiro Takeshita, MD; Takamitsu Tokioka, MD, PhD; Yasuaki Tokuhashi, MD, PhD; Juichi Tonosu, MD, PhD; Hiroshi Uei, MD, PhD; Kanichiro Wada, MD, PhD; Masahiko Watanabe, MD, PhD; Tadashi Yahata, MD; Kei Yamada, MD, PhD; Taketoshi Yasuda, MD, PhD; Keigo Yasui, MD; Toshitaka Yoshii, MD, PhD
Results of the prospective multicenter SoLKiD cohort study indicate bio-psycho-social outcome risks to kidney donors 12 months after donation
Authors: Barbara Suwelack, Klaus Berger, Heiner Wolters, Joachim W.O. Gerß, Eike Bormann, Viktorya Wörmann, Markus Burgmer, Martina Koch, Sylvia Kröncke, Rolf Weimer, Lucy Rainer, Claudia Sommerer, Martin Zeier, Klemens Budde, Fabian Halleck, Katrin Ivens, Anita Hansen, Petra Reinke, Andreas Pascher, Anja Mühlfeld, Jürgen Floege, Roger Wahba, Frank Vitinius, Andreas Kribben, Ute Eisenberger, Christian Hugo, Carmen Quick, Martin Nitschke, Inge Derad, Thomas Rath, Christian Mönch, Mario Schiffer, Faikal Güler, Bernd Krüger, Roderich Bönnighoff, Ingeborg Hauser, Steffen Platschek, Kai Lopau, Ulrich Pein, Karl Weigand, Thorsten Feldkamp, Ulrich Kunzendorf
Journal: Kidney International (2021)
Treatment Intensification and Missed Visits as Important Targets for Reducing Racial and Ethnic Disparities in Hypertension Control
Authors: Yvonne Commodore-Mensah, Cheryl Dennison Himmelfarb
Journal: JAMA Cardiology (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
A Pink Crease
Authors: Faye Ng Yu Ci
Journal: Annals of Internal Medicine (2021)

Ad LibitumNovember 2021A Pink CreaseFREEFaye Ng Yu CiFaye Ng Yu CiYong Loo Lin School of Medicine SingaporeSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M21-2263 Audio Reading - “A Pink Crease” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads “A Pink Crease” by Faye Ng Yu Ci Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail you lift the cup to your lips and setit down again. the water shrivelsup against plastic, curling backupon itself, like flowers unblooming.uncle, I sit down by his bed, whatbrought you here? what gave rise toyour skirmishes and keen eyes, the wayyou hold and rock yourself to sleepeach night? in the place where yougrew up, what time did they shutterthe shops at night? were the lightsalways this bright? which was theyear the streetlights changed tofluorescent ones? when I come aroundyou always pretend to have youreyelids drawn, your lips thinly parted.uncle, why are you so severe?the only time you spoke you showedme your scars: this one like the moon,you said, rolling up your gown,the pink line arching down your bellylike a crescent, another indentationabove your groin. I didn't grow oldto be here, you say, lifting the waterto your lips. likewise, some thingswe do not pray for. we grow ourtragedies like trees, tuck the trumpetflower buds back into themselves. Comments0 CommentsSign In to Submit A Comment GwenNone21 March 2022 Beautifully written Beautiful piece, Faye. Bravo. You make Singapore proud. R YeapSG19 March 2022 Note of appreciation Thank you. Author, Article, and Disclosure InformationAffiliations: Yong Loo Lin School of Medicine SingaporeCurrent Author Address: Faye Ng Yu Ci; e-mail, faye.[email protected]com. PreviousarticleNextarticle Advertisement Audio Reading - “A Pink Crease” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads “A Pink Crease” by Faye Ng Yu Ci Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics November 2021Volume 174, Issue 11Page: 1636 ePublished: 16 November 2021 Issue Published: November 2021 Copyright & PermissionsCopyright © 2021 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Clarification of Dosing
Authors: Zhen Wang, Juliana Vanderpluym, Mohammad Murad
Journal: JAMA (2021)

In Reply In response to our systematic review about acute treatments of migraine, 1 Dr Hagan draws attention to timolol, 0.5%, eye drops and Dr Moisset and colleagues highlight eletriptan as potential acute treatments of migraine.Both of these medications were evaluated in our systematic review; however, due to the space limitations, we presented the related studies in the accompanying Supplement.A more detailed discussion of these 2 treatments can be found in our report to the Agency for Healthcare Research and Quality. 2 In our review, 1 triptans were considered a drug class and individual triptans were not compared.Data in the triptan table were extracted from a set of published reviews that met eligibility criteria and provided data that allowed construction of the table.Regarding noninvasive vagus nerve stimulation, Moisset and colleagues argue that the strength of this evidence should be labeled as insufficient because it was derived from a single randomized trial 3 and was not statistically significant.We had downgraded the strength of evidence by 1 level due to imprecision about pain relief at 2 hours, and downgraded it by 2 levels due to severe imprecision about pain freedom at 2 hours.Lowering the strength of evidence further and calling it insufficient would make the data derived from this randomized trial similar to "no evidence" or to evidence derived from a case report.From an evidence user perspective, this randomized trial 3 presents the best available estimate for the effect of noninvasive vagus nerve stimulation as an acute therapy for migraine, although it has large statistical uncertainty, reflected by wide confidence intervals.
Histone acetylation of bile acid transporter genes plays a critical role in cirrhosis
Authors: Amanda Garrido, Eunjeong Kim, Ana Teijeiro, Paula Sánchez Sánchez, Rosa Gallo, Ajay Nair, María Matamala Montoya, Cristian Perna, Guillermo P. Vicent, Javier Muñoz, Ramón Campos-Olivas, Johannes C. Melms, Benjamin Izar, Robert F. Schwabe, Nabil Djouder
Journal: Journal of Hepatology (2021)
Trends in Prevalence and Awareness of Prediabetes Among Adults in the U.S., 2005–2020
Authors: Peng-Fei Xia, Yu-Xuan Tian, Ting-Ting Geng, Yue Li, Zhou-Zheng Tu, Yan-Bo Zhang, Kunquan Guo, Kun Yang, Gang Liu, An Pan
Journal: Diabetes Care (2021)
Covid restrictions tighten as omicron cases double every two to three days
Authors: Ingrid Torjesen
Journal: BMJ (2021)

<h3>Background</h3> Blood pressure (BP) self-screening, whereby members of the public have access to BP monitoring equipment outside of healthcare consultations, may increase the detection and treatment of hypertension. Currently in the UK such opportunities are largely confined to GP waiting rooms. <h3>Aim</h3> To investigate the reasons why people do or do not use BP self-screening facilities. <h3>Design and setting</h3> A cross-sectional, qualitative study in Oxfordshire, UK. <h3>Method</h3> Semi-structured interviews with members of the general public recruited using posters in GP surgeries and community locations were recorded, transcribed, and coded thematically. <h3>Results</h3> Of the 30 interviewees, 20% were hypertensive and almost half had self-screened. Those with no history of elevated readings had limited concern over their BP: self-screening filled the time waiting for their appointment or was done to help their doctor. Patients with hypertension self-screened to avoid the feelings they associated with 'white coat syndrome' and to introduce more control into the measurement process. Barriers to self-screening included a lack of awareness, uncertainty about technique, and worries over measuring BP in a public place. An unanticipated finding was that several interviewees preferred monitoring their BP in the waiting room than at home. <h3>Conclusion</h3> BP self-screening appeared acceptable to service users. Further promotion and education could increase awareness among non-users of the need for BP screening, the existence of self-screening facilities, and its ease of use. Waiting room monitors could provide an alternative for patients with hypertension who are unwilling or unable to monitor at home.
Correction: High Frequency of <i>PIK3R1</i> and <i>PIK3R2</i> Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability
Journal: Cancer Discovery (2021)

In the original version of this article (1), Fig. 3D was mistakenly replaced with Fig. 3C by the compositor during the production of the paper. Figure 3D has been corrected in the latest online HTML and PDF versions of the article. The publisher regrets the error.