tbuckley/cabot-search huggingface dataset:
Arterial events, venous thromboembolism, thrombocytopenia, and bleeding after vaccination with Oxford-AstraZeneca ChAdOx1-S in Denmark and Norway: population based cohort study
Authors: Anton Pottegård, Lars Christian Lund, Øystein Karlstad, Jesper Dahl, Morten Andersen, Jesper Hallas, Øjvind Lidegaard, German Tapia, Hanne Løvdal Gulseth, Paz Lopez-Doriga Ruiz, Sara Viksmoen Watle, Anders Pretzmann Mikkelsen, Lars Pedersen, Henrik Toft Sørensen, Reimar Wernich Thomsen, Anders Hviid
Journal: BMJ (2021)

Abstract Objective To assess rates of cardiovascular and haemostatic events in the first 28 days after vaccination with the Oxford-AstraZeneca vaccine ChAdOx1-S in Denmark and Norway and to compare them with rates observed in the general populations. Design Population based cohort study. Setting Nationwide healthcare registers in Denmark and Norway. Participants All people aged 18-65 years who received a first vaccination with ChAdOx1-S from 9 February 2021 to 11 March 2021. The general populations of Denmark (2016-18) and Norway (2018-19) served as comparator cohorts. Main outcome measures Observed 28 day rates of hospital contacts for incident arterial events, venous thromboembolism, thrombocytopenia/coagulation disorders, and bleeding among vaccinated people compared with expected rates, based on national age and sex specific background rates from the general populations of the two countries. Results The vaccinated cohorts comprised 148 792 people in Denmark (median age 45 years, 80% women) and 132 472 in Norway (median age 44 years, 78% women), who received their first dose of ChAdOx1-S. Among 281 264 people who received ChAdOx1-S, the standardised morbidity ratio for arterial events was 0.97 (95% confidence interval 0.77 to 1.20). 59 venous thromboembolic events were observed in the vaccinated cohort compared with 30 expected based on the incidence rates in the general population, corresponding to a standardised morbidity ratio of 1.97 (1.50 to 2.54) and 11 (5.6 to 17.0) excess events per 100 000 vaccinations. A higher than expected rate of cerebral venous thrombosis was observed: standardised morbidity ratio 20.25 (8.14 to 41.73); an excess of 2.5 (0.9 to 5.2) events per 100 000 vaccinations. The standardised morbidity ratio for any thrombocytopenia/coagulation disorders was 1.52 (0.97 to 2.25) and for any bleeding was 1.23 (0.97 to 1.55). 15 deaths were observed in the vaccine cohort compared with 44 expected. Conclusions Among recipients of ChAdOx1-S, increased rates of venous thromboembolic events, including cerebral venous thrombosis, were observed. For the remaining safety outcomes, results were largely reassuring, with slightly higher rates of thrombocytopenia/coagulation disorders and bleeding, which could be influenced by increased surveillance of vaccine recipients. The absolute risks of venous thromboembolic events were, however, small, and the findings should be interpreted in the light of the proven beneficial effects of the vaccine, the context of the given country, and the limitations to the generalisability of the study findings.
Woven Electroanalytical Biosensor for Nucleic Acid Amplification Tests
Authors: Shirin Khaliliazar, Ingrid Öberg Månsson, Andrew Piper, Liangqi Ouyang, Pedro Réu, Mahiar Max Hamedi
Journal: Advanced Healthcare Materials (2021)

Abstract Fiber‐based biosensors enable a new approach in analytical diagnostic devices. The majority of textile‐based biosensors, however, rely on colorimetric detection. Here a woven biosensor that integrates microfluidics structures in combination with an electroanalytical readout based on a thiol‐self‐assembled monolayer (SAM) for Nucleic Acid Amplification Testing, NAATs is shown. Two types of fiber‐based electrodes are systematically characterized: pure gold microwires (bond wire) and off‐the‐shelf plasma gold‐coated polyester multifilament threads to evaluate their potential to form SAMs on their surface and their electrochemical performance in woven textile. A woven electrochemical DNA (E‐DNA) sensor using a SAM‐based stem‐loop probe‐modified gold microwire is fabricated. These sensors can specifically detect unpurified, isothermally amplified genomic DNA of Staphylococcus epidermidis (10 copies/µL) by recombinase polymerase amplification (RPA). This work demonstrates that textile‐based biosensors have the potential for integrating and being employed as automated, sample‐to‐answer analytical devices for point‐of‐care (POC) diagnostics.
Noninvasive biomarkers identify eosinophilic esophagitis: A prospective longitudinal study in children
Authors: Joshua B. Wechsler, Steven J. Ackerman, Mirna Chehade, Katie Amsden, Mary E. Riffle, Ming‐Yu Wang, Jian Du, Matt L. Kleinjan, Preeth Alumkal, Elizabeth Gray, Kwang‐Youn A. Kim, Barry K. Wershil, Amir F. Kagalwalla
Journal: Allergy (2021)

Esophageal histology is critical for diagnosis and surveillance of disease activity in eosinophilic esophagitis (EoE). A validated noninvasive biomarker has not been identified. We aimed to determine the utility of blood and urine eosinophil-associated proteins to diagnose EoE and predict esophageal eosinophilia.Blood and urine were collected from children undergoing endoscopy with biopsy. Absolute eosinophil count (AEC), plasma eosinophil-derived neurotoxin (EDN), eosinophil cationic protein (ECP), major basic protein-1 (MBP-1), galectin-10 (CLC/GAL-10), Eotaxin-2 and Eotaxin-3, and urine osteopontin (OPN) and matrix metalloproteinase-9 (MMP-9) were determined. Differences were assessed between EoE and control, and with treatment response. The capacity to predict EoE diagnosis and esophageal eosinophil counts was assessed.Of 183 specimens were collected from 56 EoE patients and 15 non-EoE controls with symptoms of esophageal dysfunction; 33 EoE patients had paired pre- and post-treatment specimens. Plasma (CLC/GAL-10, ECP, EDN, Eotaxin-3, MBP-1) and urine (OPN) biomarkers were increased in EoE compared to control. A panel comprising CLC/GAL-10, Eotaxin-3, ECP, EDN, MBP-1, and AEC was superior to AEC alone in distinguishing EoE from control. AEC, CLC/GAL-10, ECP, and MBP-1 were significantly decreased in patients with esophageal eosinophil counts <15/hpf in response to treatment. AEC, CLC/GAL-10, ECP, EDN, OPN, and MBP-1 each predicted esophageal eosinophil counts utilizing mixed models controlled for age, gender, treatment, and atopy; AEC combined with MBP-1 best predicted the counts.We identified novel panels of eosinophil-associated proteins that along with AEC are superior to AEC alone in distinguishing EoE from controls and predicting esophageal eosinophil counts.
A Targeted Proteomic Approach Identifies Novel Biomarkers of Arterial Thromboembolic Risk in ENGAGE AF-TIMI 48
Authors: David D. Berg, Robert P. Giugliano, Christian T. Ruff, Minao Tang, KyungAh Im, Petr Jarolim, Howard Rutman, Elliott M. Antman, Eugene Braunwald, David A. Morrow
Journal: Journal of the American College of Cardiology (2021)
Efficacy of secukinumab and adalimumab in patients with psoriatic arthritis and concomitant moderate‐to‐severe plaque psoriasis: results from EXCEED, a randomized, double‐blind head‐to‐head monotherapy study
Authors: A.B. Gottlieb, J.F. Merola, K. Reich, F. Behrens, P. Nash, C.E.M. Griffiths, W. Bao, P. Pellet, L. Pricop, I.B. McInnes
Journal: British Journal of Dermatology (2021)

Background Secukinumab [an interleukin (IL)-17A inhibitor] has demonstrated significantly higher efficacy vs. etanercept (a tumour necrosis factor inhibitor) and ustekinumab (an IL-12/23 inhibitor) in patients with moderate-to-severe plaque psoriasis. Objectives To report 52-week results from a prespecified analysis of patients with active psoriatic arthritis (PsA) having concomitant moderate-to-severe plaque psoriasis from the head-to-head EXCEED monotherapy study comparing secukinumab with adalimumab. Methods Patients were randomized to receive secukinumab 300 mg via subcutaneous injection at baseline, week 1–4, and then every 4 weeks until week 48 or adalimumab 40 mg via subcutaneous injection every 2 weeks from baseline until week 50. Assessments in patients with concomitant moderate-to-severe psoriasis, defined as having affected body surface area > 10% or Psoriasis Area and Severity Index (PASI) ≥ 10 at baseline, included musculoskeletal, skin and quality-of-life outcomes. Missing data were handled using multiple imputation. Results Of the 853 patients [secukinumab (N = 426), adalimumab (N = 427)], 211 (24·7%) had concomitant moderate-to-severe psoriasis [secukinumab (N = 110, 25·8%), adalimumab (N = 101, 23·7%)]. Up to week 50, 5·5% of patients discontinued secukinumab vs.17·8% in the adalimumab group. The proportion of patients who achieved American College of Rheumatology (ACR) 20 response was 76·4% with secukinumab vs. 68·3% with adalimumab (P = 0·175), PASI 100 response was 39·1% vs. 23·8% (P = 0·013), and simultaneous improvement in ACR 50 and PASI 100 response at week 52 was 28·2% vs. 17·7%, respectively (P = 0·06). Secukinumab demonstrated consistently higher responses vs. adalimumab across skin endpoints. Conclusions This prespecified analysis in PsA patients with concomitant moderate-to-severe plaque psoriasis in the EXCEED study provides further evidence that IL-17 inhibitors offer a comprehensive biological treatment to manage the concomitant features of psoriasis and PsA.
B cells join T cell clusters in the host response to recurrent herpes simplex virus 2 infection
Authors: Jeff R. Gehlhausen, Akiko Iwasaki
Journal: Journal of Clinical Investigation (2021)

Recurrent genital herpes lesions are infiltrated by various leukocytes, yet the role of B cell subsets in this process is unknown. In this issue of the JCI, Ford et al. describe the presence and antibody-secreting role of local B cell populations in herpes simplex virus 2 (HSV-2) recurrent lesions. The authors analyzed a comprehensive array of sequential skin biopsy specimens from HSV-2-infected patients over time and at various stages of infection. Using immunofluorescence and in situ hybridization, the authors show the presence of rare IgD+ naive B cells and IgG-expressing antibody-secreting cells (ASCs) in recurrent HSV-2 lesions embedded in CD4+ T cell-rich dermal immune infiltrates, levels of which transiently increase during lesion reactivation and healing. Notably, local increases in HSV-2-specific antibodies in recurrent lesions were detected, whereas serum HSV-2 antibody levels remained stable. Future research is needed to understand the precise role of these tissue-visiting B cells in disease resolution.
AN ORIGINAL RISK SCORE TO PREDICT IN-HOSPITAL MAJOR BLEEDING IN ACUTE PULMONARY EMBOLISM: THE SYNCOPE, ANEMIA, RENAL DYSFUNCTION (PE-SARD) BLEEDING SCORE
Authors: Romain Chopard, Fiona Ecarnot, Matthieu Besutti, Nicolas Falvo, Francois Schiele, Nicolas Meneveau
Journal: Journal of the American College of Cardiology (2021)
IMPACT OF VENTRICULAR TACHYCARDIA ELECTRICAL STORM ON CONTRACTILE PERFORMANCE OF HUMAN MYOCARDIUM
Authors: Mohammed Mashali, Georges Daoud, Aditya More, Carlos Arias Bermudez, Rami Kahwash, Nancy Saad, Kyra Peczkowski, Amanda Huang, Farbod Fazlollahi, Austin Hare, Courtney Campbell, Paul Janssen
Journal: Journal of the American College of Cardiology (2021)
Hepatocytes Induce Change in Their Neighbors by YAP‐ing at Them
Authors: Eeeln Buckarma, Rory Smoot
Journal: Hepatology (2021)

Buckarma, Eeeln M.D.; Smoot, Rory M.D.Editor(s): Corey, Kathleen E.2; Malhi, Harmeet3 Author Information
CARDIOVASCULAR DISEASE RISK FACTORS IN CHILDREN AND ADULTS WITH CONGENITAL HEART DISEASE ARE ASSOCIATED WITH HEART FAILURE: A POPULATION-BASED MULTI-SITE CROSS SECTIONAL ANALYSIS
Authors: Andrew P. Landstrom, Tracy Spears, Alfred D’Ottavio, Karen Chiswell, Kristin Sommerhalter, Aida Soim, Sherry Farr, Tessa Crume, Wendy Book, Kevin Whitehead, Lorenzo Botto, Jennifer Li, Daphne Hsu
Journal: Journal of the American College of Cardiology (2021)
ASSOCIATION BETWEEN LEFT VENTRICULAR EJECTION FRACTION IMPROVEMENT AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT AND 5-YEAR SURVIVAL: AN ANALYSIS OF THE PARTNER TRIALS AND REGISTRIES
Authors: Dhaval Kolte, Bhaskar Bhardwaj, Yanjun Chen, Maria Alu, Jonathan Passeri, Ignacio Inglessis, Gus Vlahakes, Santiago Garcia, David Cohen, Brian Lindman, Susheel Kodali, Vinod Thourani, Pamela Douglas, Wael Jaber, Philippe Pibarot, Igor Palacios, Martin Leon, Craig Smith, Michael Mack, Sammy Elmariah
Journal: Journal of the American College of Cardiology (2021)
COMPARISON OF IN-HOSPITAL OUTCOMES OF TRANSCATHETER AORTIC VALVE REPLACEMENT IN PATIENTS WITH PREEXISTING COMPARED TO POSTOPERATIVE PERMANENT PACEMAKER IMPLANTATION
Authors: Bertrand F. Ebner, Jelani Grant, Louis Vincent, Jennifer Maning, Neal Olarte, Odunayo Olorunfemi, Rosario Colombo, Eduardo De Marchena
Journal: Journal of the American College of Cardiology (2021)
Magnetic systems for cancer immunotherapy
Authors: Nicole B. Day, William C. Wixson, C. Wyatt Shields
Journal: Acta Pharmaceutica Sinica B (2021)

Immunotherapy is a rapidly developing area of cancer treatment due to its higher specificity and potential for greater efficacy than traditional therapies. Immune cell modulation through the administration of drugs, proteins, and cells can enhance antitumoral responses through pathways that may be otherwise inhibited in the presence of immunosuppressive tumors. Magnetic systems offer several advantages for improving the performance of immunotherapies, including increased spatiotemporal control over transport, release, and dosing of immunomodulatory drugs within the body, resulting in reduced off-target effects and improved efficacy. Compared to alternative methods for stimulating drug release such as light and pH, magnetic systems enable several distinct methods for programming immune responses. First, we discuss how magnetic hyperthermia can stimulate immune cells and trigger thermoresponsive drug release. Second, we summarize how magnetically targeted delivery of drug carriers can increase the accumulation of drugs in target sites. Third, we review how biomaterials can undergo magnetically driven structural changes to enable remote release of encapsulated drugs. Fourth, we describe the use of magnetic particles for targeted interactions with cellular receptors for promoting antitumor activity. Finally, we discuss translational considerations of these systems, such as toxicity, clinical compatibility, and future opportunities for improving cancer treatment.
LEFT ATRIAL PRESSURE CORRELATION WITH PERSISTENT IATROGENIC ATRIAL SEPTAL DEFECT AFTER MITRACLIP IMPLANTATION
Authors: Prince Sethi, Nikhil Parimi, Prakash Acharya, Amandeep Goyal, Emmanuel Daon, George Zorn, Peter Tadros, Mark Wiley
Journal: Journal of the American College of Cardiology (2021)
Spire Healthcare pleads guilty to failing to tell four patients about poor treatment
Authors: Clare Dyer
Journal: BMJ (2021)

The private hospital group Spire Healthcare has pleaded guilty to breaching the duty of candour in failing to give four patients prompt explanations about their inadequate treatment by a consultant orthopaedic surgeon.

The guilty plea came in the first case to be brought by the Care Quality Commission against a private healthcare provider for breaching the duty of candour. Spire was fined £5000 and ordered to pay a £120 victim surcharge and £14 984.36 costs at Leeds magistrates court.

The procedures were performed by Mike Walsh, a consultant orthopaedic surgeon who worked at Spire Leeds Hospital until his practising privileges were …
Reconstructing the Human Genetic History of Mainland Southeast Asia: Insights from Genome-Wide Data from Thailand and Laos
Authors: Wibhu Kutanan, Dang Liu, Jatupol Kampuansai, Metawee Srikummool, Suparat Srithawong, Rasmi Shoocongdej, Sukrit Sangkhano, Sukhum Ruangchai, Pittayawat Pittayaporn, Leonardo Arias, Mark Stoneking
Journal: Molecular Biology and Evolution (2021)

Thailand and Laos, located in the center of Mainland Southeast Asia (MSEA), harbor diverse ethnolinguistic groups encompassing all five language families of MSEA: Tai-Kadai (TK), Austroasiatic (AA), Sino-Tibetan (ST), Hmong-Mien (HM), and Austronesian (AN). Previous genetic studies of Thai/Lao populations have focused almost exclusively on uniparental markers and there is a paucity of genome-wide studies. We therefore generated genome-wide SNP data for 33 ethnolinguistic groups, belonging to the five MSEA language families from Thailand and Laos, and analyzed these together with data from modern Asian populations and SEA ancient samples. Overall, we find genetic structure according to language family, albeit with heterogeneity in the AA-, HM-, and ST-speaking groups, and in the hill tribes, that reflects both population interactions and genetic drift. For the TK speaking groups, we find localized genetic structure that is driven by different levels of interaction with other groups in the same geographic region. Several Thai groups exhibit admixture from South Asia, which we date to ∼600-1000 years ago, corresponding to a time of intensive international trade networks that had a major cultural impact on Thailand. An AN group from Southern Thailand shows both South Asian admixture as well as overall affinities with AA-speaking groups in the region, suggesting an impact of cultural diffusion. Overall, we provide the first detailed insights into the genetic profiles of Thai/Lao ethnolinguistic groups, which should be helpful for reconstructing human genetic history in MSEA and selecting populations for participation in ongoing whole genome sequence and biomedical studies.
Abstract 14640: Inpatient Management and Outcomes for HIV-Infected Patients Hospitalized for Acute Coronary Syndromes
Authors: Monica Parks, Eric A Secemsky, Robert W Yeh, Changyu Shen, Eunhee Choi, Dhruv S Kazi, Priscilla Hsue
Journal: Circulation (2019)

Introduction: HIV-infected adults have excess morbidity and mortality from cardiovascular disease. Differences in the presentation and management of acute coronary syndromes (ACS) in this populatio...
Abstract 18079: Among CHD Patients in the IDEAL Study, Those with Elevated Levels of Alanine Aminotransferase at Baseline Had a Lower Rate of Major Coronary Events
Authors: Matti J Tikkanen, Rana Fayyad, Rachel Laskey, Ingar Holme, Ole Faergeman, Anders G Olsson, Christina Lindahl, John J Kastelein, Mogens Lytken Larsen, Terje R Pedersen
Journal: Circulation (2011)

Background: Previous evidence suggests that statin therapy can reduce cardiovascular (CV) morbidity in patients with mild-to-moderately abnormal liver tests. In this post hoc analysis of the IDEAL study, we investigated the relationship of elevated baseline levels of the liver enzyme alanine aminotransferase (ALT) on CV events, and compared the effects of atorvastatin (ATV) 80 mg versus simvastatin (SIM) 20-40 mg in patients with normal and elevated baseline ALT levels. Methods: IDEAL was a large randomized trial comparing ATV 80 mg with SIM 20-40 mg in 8888 patients with CHD over 4.8 years of follow-up. Cox regression analysis was performed to investigate the relationship of normal levels of ALT (defined as baseline ALT &lt;ULN [upper limit of normal]; 87.8% of subjects) vs elevated ALT (baseline ALT ≥ULN; 11.5% of subjects had ALT ≥ULN-&lt;2 ULN and 0.74% had ALT ≥2 ULN-&lt;3 ULN) on the risk of major coronary events (MCE: CHD death, non-fatal MI or resuscitated cardiac arrest). In addition, treatment effect (ATV 80mg vs SIM 20-40 mg) was examined for subjects with normal and elevated ALT at baseline. Results: Over the course of the study, mean ALT levels increased among patients with normal baseline ALT (n=7782) and decreased for those with ALT ≥ULN at baseline (n=1081). Overall, those patients with normal ALT levels at baseline experienced significantly more MCE than patients with higher baseline ALT levels (≥ULN) (HR=0.76; 95% CI 0.61, 0.96; p=0.02). This finding was consistent in patients treated with ATV (HR=0.60; 95% CI 0.42, 0.87; p=0.007) but not those receiving SIM (p=0.464). In patients with elevated ALT baseline levels, ATV significantly reduced the risk of MCE compared with SIM (HR=0.62; 95% CI 0.40, 0.96; p=0.03), but in patients with normal baseline ALT the difference between treatment groups did not reach statistical significance. Conclusions: In the overall population of CHD patients treated with ATV or SIM, those with normal baseline ALT levels experienced significantly more MCE than those with baseline ALT ≥ULN. The clinical benefits of intensive lipid lowering with ATV compared with a more moderate regimen with SIM were generally greater in patients with abnormal liver tests than in patients with normal liver tests.
SURVIVAL AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT WITH OR WITHOUT PACEMAKER IMPLANTATION
Authors: Grzegorz Jarosinski, Marek Jasinski, Marek Deja, Andrzej Ochala, Danuta Loboda, Damian Hudziak, Wojciech Wojakowski, Krzysztof Golba
Journal: Journal of the American College of Cardiology (2021)
SIGNIFICANCE OF THE PRESENCE AND DISTRIBUTION OF J WAVES IN PULMONARY HYPERTENSIVE PATIENTS RELATIONSHIP WITH THE PRESENCE OF RIGHT VENTRICULAR HYPERTROPHY OR FIBROSIS AND CRITICAL VENTRICULAR ARRHYTHMIA
Authors: Nobusada Funabashi, Koya Ozawa, Koki Nakamura, Nobuhiro Tanabe, Shigeto Naito, Koichiro Tatsumi, Yoshio Kobayashi
Journal: Journal of the American College of Cardiology (2021)
GLYPHOSATE POISONING: COMMON WEED KILLER, BUT RARE HEART KILLER
Authors: Jonathan Cordero-Jimé nez, Karelys Burgos Irizarry, Hector Oliveras Cordero, Jorge Juan Ballester Maldonado, Carla Colon Núñ ez, Karina Cancel Artua, Alfredo Lamela, Pedro Vargas Otero
Journal: Journal of the American College of Cardiology (2021)
HEMODYNAMICS AND CLINICAL IMPLICATIONS OF OCCULT LEFT VENTRICULAR DYSFUNCTION IN ADULTS UNDERGOING EBSTEIN ANOMALY REPAIR
Authors: Alexander C. Egbe, Momina Iftikhar, Renuka Reddy Katta, Likhita Shaik, Janaki Devara, Heidi Connolly
Journal: Journal of the American College of Cardiology (2021)
A cross-sectional study of no-show rates and factors contributing to nonattendance at 3 academic pediatric dermatology centers in the United States
Authors: Danielle N. Brown, Bridget E. Shields, Samarth Shrivastava, Katie Welsh, Adnan Mir, Joy Wan, Linda S. Hynan, Lisa Arkin, Carrie Kovarik, Benjamin F. Chong
Journal: Journal of the American Academy of Dermatology (2021)