tbuckley/cabot-search huggingface dataset:
Findings Linking Mismatch Repair Mutation With Age at Endometrial and Ovarian Cancer Onset in Lynch Syndrome
Authors: Giorgio Bogani, Umberto Leone Roberti Maggiore, Domenica Lorusso, Francesco Raspagliesi
Journal: JAMA Oncology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Accuracy and Inter-Observer Agreement of the Nice and the Kudo Classifications of Superficial Colonic Lesions: A Comparative Study
Authors: F Cocomazzi, M Gentile, F Perri, F Bossa, A Merla, A Ippolito, R Cubisino, S Carparelli, A Marra, A Mileti, R Paolillo, M Piazzolla, M Copetti, P Parente, P Graziano, A Di Leo, A Andriulli
Journal: Endoscopy (2021)

Aims For superficial colonic lesions, the NICE and the Kudo classifications are used in the in vivo prediction of histology and as a guide to therapy. The NICE system derives information from unmagnified NBI endoscopic images. The Kudo one necessitates a magnification but, as this tool is not commonly available, it is applied also to characterize unmagnified pictures. To compare the diagnostic performances of the two classifications.
Intracoronary adenosine administered after reperfusion limits vascular injury after prolonged ischemia in the canine model.
Authors: D GBabbitt, RVirmani, M BForman
Journal: Circulation (1989)

Myocardial salvage after reperfusion may be limited by deleterious vascular changes in the previously ischemic microcirculatory bed. This could result in a progressive decrease in blood flow in the capillary bed to potentially viable myocytes (no-reflow phenomenon). The effect of intracoronary adenosine on these changes was assessed in 15 closed-chest dogs subjected to 2 hours of proximal left anterior descending artery (LAD) occlusion followed by 3 hours of reperfusion. Animals randomly received adenosine (n = 8) 3.75 mg/min into the proximal LAD or an equivalent volume of saline (control) (n = 7) for 1 hour after reperfusion. Endothelial-dependent and independent coronary vasodilator reserve was determined using a chronically implanted volume-flowmeter on the mid-LAD at baseline and 1 and 3 hours after reperfusion with acetylcholine and papaverine infusions, respectively, into the proximal vessel. Regional myocardial blood flow was measured serially with radioactive microspheres and regional contractile...
EUS-Guided Biliary Drainage (EUS-BD) With Lumen Apposing Metal Stent (LAMS) For Unresectable Malignant Biliary Obstruction (MBO) After Ercp Failure: Single-Center Real-Life Retrospective-Study With Maldeployment Management
Authors: R Di Mitri, M Amata, F Mocciaro, A Bonaccorso, E Conte, M Lo Mastro, D Scimeca
Journal: Endoscopy (2021)

Aims EUS-BD with LAMS is a mini-invasive modality treatment for jaundice palliation in distal MBO not amenable to ERCP, with good efficacy and not insignificant reported Adverse Events (AEs) rate.
Conjugation to antifibrin Fab' enhances fibrinolytic potency of single-chain urokinase plasminogen activator.
Authors: CBode, M SRunge, SSchönermark, TEberle, J BNewell, WKübler, EHaber
Journal: Circulation (1990)

Single-chain urokinase plasminogen activator (scu-PA) that had been modified with N-succinimidyl-3-(2-pyridyldithio)propionate was covalently linked by disulfide bonds to the Fab' of a monoclonal antibody specific for the beta-chain of fibrin (antibody 59D8). scu-PA-59D8 Fab' conjugate was separated from free scu-PA and two-chain urokinase coupled to 59D8 Fab' by two-step affinity chromatography. First, the reaction mixture was chromatographed on a column containing Sepharose linked to the peptide that had been used as immunogen for antibody 59D8; scu-PA-59D8 Fab' conjugate and unconjugated 59D8 Fab' were retained but not unconjugated scu-PA. Then, the eluate from the peptide-Sepharose column was chromatographed on a column containing Sepharose linked to benzamidine, which acts as a ligand for two-chain urokinase. The molecular weight of the scu-PA-59D8 Fab' conjugate was approximately 100 kDa when electrophoresed on a nonreducing sodium dodecylsulfate-polyacrylamide gel. Enzymatic assay after purificatio...
The problem of valve prosthesis-patient mismatch.
Authors: S HRahimtoola
Journal: Circulation (1978)

Valve prostheses have played an important part in the past two decades in the management of patients with valvular heart disease. However, many of the devices used in valve replacement have introduced new clinical problems. This paper deals with some of the problems associated with valve replacement, including one not previously emphasized--valve prosthesis-patient mismatch, which may cause obstruction to ventricular outflow and/or inflow.
Early outcomes after lung transplantation for severe COVID-19: a series of the first consecutive cases from four countries
Authors: Ankit Bharat, Tiago N Machuca, Melissa Querrey, Chitaru Kurihara, Rafael Garza-Castillon, Samuel Kim, Adwaiy Manerikar, Andres Pelaez, Mauricio Pipkin, Abbas Shahmohammadi, Mindaugas Rackauskas, Suresh Rao KG, K R Balakrishnan, Apar Jindal, Lara Schaheen, Samad Hashimi, Bhuvin Buddhdev, Ashwini Arjuna, Lorenzo Rosso, Alessandro Palleschi, Christian Lang, Peter Jaksch, G R Scott Budinger, Mario Nosotti, Konrad Hoetzenecker
Journal: The Lancet Respiratory Medicine (2021)
Stimulation of slow action potentials in guinea pig papillary muscle cells by intracellular injection of cAMP, Gpp(NH)p, and cholera toxin.
Authors: TLi, NSperelakis
Journal: Circulation Research (1983)

To test the hypothesis that intracellular cAMP has a regulatory role in cardiac slow channel function, intracellular pressure injections of cAMP and adenylate cyclase activators, Gpp(NH)p and cholera toxin, were carried out. Guinea pig papillary muscles were depolarized to about -45 mV by superfusion with 22 mM K+-Tyrode's solution to inactivate the fast Na+ channels. Induction of slow action potentials or enhancement of ongoing slow action potentials was observed in about 70% of all cells in which a successful intracellular injection of the testing compounds was obtained. The slow AP is highly dependent on slow inward current and is known to be enhanced by catecholamines. The effect of the injected cyclic nucleotides and related compounds occurred within 3 minutes after starting the injection, whereas superfusion with these compounds (dibutyryl cAMP was used in place of cAMP) required 10-30 minutes to show an effect. This difference is attributed to the intracellular injection of the compound. The effect...
Effect of aspirin on coronary collateral blood flow.
Authors: J DAltman, DDulas, TPavek, R JBache
Journal: Circulation (1993)

BACKGROUNDAlthough aspirin exerts beneficial antiplatelet activity in patients with coronary artery disease, cyclooxygenase blockade produced by aspirin causes a potentially deleterious effect by interrupting endothelial production of prostacyclin. Collateral vessels that develop in response to coronary occlusion display prominent endothelial cell proliferation and undergo vasoconstriction in response to indomethacin. This study was performed to test the hypothesis that cyclooxygenase blockade with aspirin would cause constriction of coronary collateral vessels and that such vasoconstriction would be reversed with nitroglycerin.METHODS AND RESULTSCollateral vessel growth was induced by embolic occlusion of the left anterior descending coronary artery in dogs. Four to 6 months later, coronary collateral flow was measured as retrograde flow from the cannulated collateral-dependent artery. Aspirin (1 mg/kg i.v.) caused 70 +/- 8% blockade of the increase in coronary blood flow produced by intra-arterial arach...
Serum digitoxin concentrations in infants and children.
Authors: A CGiardina, K HEhlers, J BMorrison, M AEngle
Journal: Circulation (1975)

Serum digitoxin levels were measured in 18 infants (under two years) and in 23 children (aged 2-13 years) receiving maintenance therapy. Digitalization was carried out because of heart failure in 17 infants and 13 children and for control of dysrhythmia in one infant and 10 children. Mean maintenance dosage for infants was 0.0042 plus or minus 0.0008 (sd) mg/kg/day and for children was 0.0031 plus or minus 0.0012 mg/kg/day. The mean serum digitoxin level was not significantly different in infants (30 plus or minus 10 ng/ml, range 14-58) from that found for children (34 plus or minus 11 ng/ml, range 19-61). Both values were significantly different (P smaller than 0.001) from those determined in this laboratory for adults (mean 24 plus or minus 7 ng/ml, range 5-39). In four infants with electrocardiographic or other evidence of toxicity, the mean serum level was 71 plus or minus 2 ng/ml (range 68-72), and in four children with electrocardiographic or other evidence of toxicity, the mean serum level for digi...
Combined Forward and Retroflexion Withdrawal During Colonoscopy Using A Second-Generation Short-Turn Radius Colonoscope
Authors: C Robles-Medranda, R Oleas, J Alcivar-Vasquez, M Puga-Tejada, C Cifuentes, R Del Valle, H Alvarado, D Armas, AC Lopez, H Pitanga-Lukashok
Journal: Endoscopy (2021)

Aims We aimed to evaluate the impact of combined forward and retroflexion withdrawal using a second-generation short-turn radius colonoscope during colonoscopy.
Perfusion pressure and volume status determine the microvascular response of the rat kidney to NG-monomethyl-L-arginine.
Authors: J CLockhart, T SLarson, F GKnox
Journal: Circulation Research (1994)

This study investigated the role of volume status and perfusion pressure on the hemodynamic response of cortical and medullary renal capillaries to systemic inhibition of nitric oxide. NG-Monomethyl-L-arginine (L-NMMA) was infused intravenously (15-mg/kg bolus and 500-micrograms.min-1.kg-1 infusion), and blood flow in cortical capillaries (QCC) and in descending (QDVR) and ascending vasa recta (QAVR) was measured by fluorescence videomicroscopy in euvolemic and volume-expanded anesthetized Munich-Wistar rats. L-NMMA in euvolemic rats decreased vasa recta blood flow (delta QDVR, 3.97 +/- 0.80 nL/min [P < .01]; delta QAVR, 1.90 +/- 0.39 nL/min [P < .01]; n = 6) and QCC (delta QCC, 0.57 +/- 0.15 nL/min [P < .01]; n = 7) despite increases in renal perfusion pressure (RPP). Fractional excretion of sodium (FENa) remained unchanged. In volume-expanded rats, L-NMMA decreased vasa recta blood flow when RPP increased (delta QDVR, 1.42 +/- 0.79 nL/min [P = .05]; delta QAVR, 1.95 +/- 0.34 nL/min [P < .001]; n = 9) or...
Priming by platelet-activating factor of endotoxin-induced lung injury and cardiovascular shock.
Authors: RRabinovici, K MEsser, P GLysko, T LYue, D EGriswold, L MHillegass, P JBugelski, J MHallenbeck, GFeuerstein
Journal: Circulation Research (1991)

Platelet-activating factor (PAF) is a glycerophospholipid known for its unusual potent vasoactive and proinflammatory activities. The present study examined whether PAF might serve as a priming factor in endotoxin-induced tumor necrosis factor-alpha (TNF alpha) synthesis, cardiovascular shock, and lung injury in anesthetized rats. Intravenous infusion of PAF (1 pmol/kg/min for 60 minutes, n = 5) alone or endotoxin (0.1 micrograms/kg i.v. bolus, n = 5) failed to alter blood pressure, serum TNF alpha and thromboxane B2, platelet and leukocyte count, and hematocrit, nor was lung histology, myeloperoxidase activity, and water content changed. In contrast, the combined administration of PAF and endotoxin markedly elevated serum TNF alpha (1,359 +/- 362 pg/ml, n = 5, p less than 0.01) and thromboxane B2 (43 +/- 5 pg/100 microliters, n = 8, p less than 0.01) along with hypotension, hemoconcentration, leukopenia, and thrombocytopenia. Most notably, the combined regimen caused neutrophil aggregation, adhesion, and...
Injectable silk sericin scaffolds with programmable shape-memory property and neuro-differentiation-promoting activity for individualized brain repair of severe ischemic stroke
Authors: Jian Wang, Xiaolin Li, Yu Song, Qiangfei Su, Xiakeerzhati Xiaohalati, Wen Yang, Luming Xu, Bo Cai, Guobin Wang, Zheng Wang, Lin Wang
Journal: Bioactive Materials (2020)

Severe ischemic stroke damages neuronal tissue, forming irregular-shaped stroke cavities devoid of supporting structure. Implanting biomaterials to provide structural and functional support is thought to favor ingrowth of regenerated neuronal networks. Injectable hydrogels capable of in situ gelation are often utilized for stroke repair, but challenged by incomplete gelation and imprecise control over end-macrostructure. Injectable shape-memory scaffolds might overcome these limitations, but are not explored for stroke repair. Here, we report an injectable, photoluminescent, carbon-nanotubes-doped sericin scaffold (CNTs-SS) with programmable shape-memory property. By adjusting CNTs' concentrations, CNTs-SS' recovery dynamics can be mathematically calculated at the scale of seconds, and its shapes can be pre-designed to precisely match any irregular-shaped cavities. Using a preclinical stroke model, we show that CNTs-SS with the customized shape is successfully injected into the cavity and recovers its pre-designed shape to well fit the cavity. Notably, CNTs-SS' near-infrared photoluminescence enables non-invasive, real-time tracking after in vivo implantation. Moreover, as a cell carrier, CNTs-SS not only deliver bone marrow mesenchymal stem cells (BMSCs) into brain tissues, but also functionally promote their neuronal differentiation. Together, we for the first time demonstrate the feasibility of applying injectable shape-memory scaffolds for stroke repair, paving the way for personalized stroke repair.
Plasma thromboxane B2 concentration in pulmonary hypertension associated with congenital heart disease.
Authors: SFuse, TKamiya
Journal: Circulation (1994)

BACKGROUNDWe investigated the plasma concentration of thromboxane B2 (TXB2), a stable metabolite of thromboxane A2 (TXA2), to assess platelet activation in 78 patients who had pulmonary hypertension associated with congenital heart disease (PH group) and 16 patients with almost normal hemodynamics (control group).METHODS AND RESULTSThe PH group was divided into two subgroups: pulmonary vascular resistance (Rp)   10 U/m2 (Rp > 10 group). In addition, the Rp   10) were significantly different (P < .005); the TXB2 levels in the Rp < or = 10 group were significantly higher than the others. Among the Rp < or = 10 patients, the plasma TXB2 levels were significantly higher in the dyspnea(+) group than in the...
Risk factors for postoperative morbidity after thyroid surgery in a PROSPECTIVE cohort of 1500 patients
Authors: Sam Van Slycke, Klaas Van Den Heede, Niels Bruggeman, Hubert Vermeersch, Nele Brusselaers
Journal: International Journal of Surgery (2021)

Postoperative hypocalcaemia, recurrent laryngeal nerve palsy and postoperative bleeding are the most frequent postoperative complications after thyroid surgery, and therefore often used as quality indicators of thyroid surgery. We aimed to assess postoperative morbidity in a high-volume endocrine surgery unit, and to detect which factors are associated with higher risks. Prospective surgical cohort in a high-volume tertiary referral centre for endocrine surgery in xxx. The first 1500 patients operated with hemi or total thyroidectomy during 2010–2019 were included. Postoperative hypocalcaemia, recurrent laryngeal nerve palsy and postoperative bleeding were assessed in relation to pre- and peri-operative characteristics using multivariable logistic regression analyses, expressed as odds ratios and 95% confidence intervals. Overall, 1043 patients (69.5%) received a total thyroidectomy and 457 (30.5%) a hemithyroidectomy. Permanent hypocalcaemia occurred in 3.1%, permanent recurrent laryngeal nerve palsy in 1.8% and surgical reintervention for bleeding in 2.6%. Younger age, female sex and cancer were risk factors for permanent hypocalcaemia. No clear risk factors could be identified for permanent nerve palsy. Female sex, high body mass index and heavier thyroids were protective against postoperative bleeding after total thyroidectomy. Surgical experience in endocrine surgery seems beneficial for clinical outcomes and contributes to organizational efficiency. A low complication risk can be obtained by trained high-volume endocrine surgeons, yet the risk is not negligible.
Hematopoietic stem progenitor cells lacking HLA differ from those lacking GPI-anchored proteins in the hierarchical stage and sensitivity to immune attack in patients with acquired aplastic anemia
Authors: Takeshi Yoroidaka, Kohei Hosokawa, Tatsuya Imi, Hiroki Mizumaki, Takamasa Katagiri, Ken Ishiyama, Hirohito Yamazaki, Fumihiro Azuma, Yasuhito Nanya, Seishi Ogawa, Shinji Nakao
Journal: Leukemia (2021)
Arrhythmogenic effects of graded coronary blood flow reductions superimposed on prior myocardial infarction in dogs.
Authors: TFurukawa, KMoroe, H NMayrovitz, RSampsell, NFurukawa, R JMyerburg
Journal: Circulation (1991)

BACKGROUNDWe studied arrhythmogenesis and its underlying pathophysiology during graded reductions of coronary blood flow, superimposed on prior myocardial infarction to test the hypothesis that spontaneous ventricular fibrillation and induced ventricular tachycardia are dependent on different patterns of coronary flow reduction in hearts with prior myocardial infarction.METHODS AND RESULTSIn 10 sham-operated dogs (control group) and 24 dogs with 3-week-old experimental apical myocardial infarction, the left circumflex coronary artery was constricted to produce four grades of flow reduction: 25%, 50%, 75%, and 100%. Among the sham-operated control animals, only one of 10 (10%) developed spontaneous ventricular fibrillation and only two of nine (22%) were inducible into sustained ventricular tachycardia during 100% circumflex coronary artery flow reduction. No spontaneous ventricular fibrillation or inducible ventricular tachycardia occurred with lesser grades (25%, 50%, or 75%) of flow reduction among the ...
Anatomic effects of cryoablation of the atrioventricular conduction system.
Authors: SOhkawa, D BHackel, E MMikat, J JGallagher, J LCox, W CSealy
Journal: Circulation (1982)

Because of the value of cryoablation of the atrioventricular (AV) conduction system in treatment of refractory cardiac rhythm disorders, the anatomic effects of cryoablation on the cardiac conduction system must be defined. In this report we summarize studies done on four patients who had intractable recurrent supraventricular tachyarrhythmias or or refractory atrial flutter-fibrillation. They were treated by cryoablation of the AV conduction system and died 8-360 days postoperatively. Serial sections of the AV conduction system were studied. Cryoablation produced lesions that completely destroyed most of the AV node in three cases, the penetrating portion of the His bundle in all four cases, and the branching portion of the His bundle in two cases. The right bundle branch was not involved markedly in any case. The lesions were discrete and sharply delimited; the patient who died 8 days postoperatively had hemorrhage, necrosis and slight inflammatory infiltrate; patients who survived for 49-360 days showe...
Changes in the National Cancer Institute’s R01 workforce: growth, aging, retention, and policy implications
Authors: Melissa D. Antman, Roman Gorelik, Amy Kennedy, Grace F. Liou, Eddie N. Billingslea, James G. Corrigan, L. Michelle Bennett
Journal: Journal of Clinical Investigation (2021)

Scientific progress and discovery of preventions and cures for life-threatening diseases depend on the vitality of the biomedical research workforce. We analyzed the workforce of cancer researchers applying for and receiving R01 awards from the National Cancer Institute (NCI) from fiscal years 1990 to 2016, the last year prior to implementation of the Next Generation Researchers Initiative. Here we report that the NCI R01 Principal Investigator (PI) workforce expanded 1.4-fold and aged over this time frame. We tracked 9 age groups and found that the number of PIs in the 3 oldest groups increased dramatically, in contrast with the younger groups. Sustained increases in the number of funded older PIs stemmed from increases in the number of older PIs submitting applications, rather than higher funding rates for older PIs. The decline in the number of funded younger PIs was driven in part by (a) a marked increase in time from PhD degree to first R01 application and award, as well as (b) a decrease in retention of PIs in the funded R01 workforce beyond their first R01 award. The NCI is using these and other analyses to inform strategies and policies for attracting, supporting, and retaining meritorious early-career researchers.
Clinical and pathologic features of obstructive disease in the predominant right and left coronary circulations in man.
Authors: R JBoucek, RRomanelli, W HWillis, W AMitchell
Journal: Circulation (1980)

The clinical features and the location and severity of obstructive coronary artery disease are contrasted in 98 patients with predominant left and 99 patients with predominant right coronary circulations. A significantly higher incidence of ventricular conduction disturbances and a greater incidence and severity of obstructive coronary artery disease (greater than or equal to 70% cross-sectional narrowing in the proximal left anterior descending, circumflex and right coronary arteries and their major branches) distinguish the predominant left from the predominant right coronary circulation. The results suggest an anatomically disadvantaged status for the predominant left compared with the predominant right coronary circulations with respect to ventricular conduction disturbances and to coronary atherogenesis in man.
SARS-CoV-2 infections in people with primary ciliary dyskinesia: neither frequent, nor particularly severe
Authors: Eva S.L. Pedersen, Myrofora Goutaki, Amanda L. Harris, Lucy Dixon, Michele Manion, Bernhard Rindlisbacher, COVID-PCD patient advisory group, Jane S. Lucas, Claudia E. Kuehni
Journal: European Respiratory Journal (2021)

<b>In this longitudinal study of people with PCD followed weekly <i>via</i> online questionnaires, the incidence rate of COVID-19 and the proportion of participants infected were low, and the observed severity mostly mild</b>https://bit.ly/3frKICr