tbuckley/cabot-search huggingface dataset:
Comparison of quality of life (QoL) in survivors of testicular nonseminomatous germ cell tumor (NSGCT) with age-matched controls using EORTC QLQ-C30 questionnaire.
Authors: ANKUR NANDAN VARSHNEY, Abhishek Raj, Prabhjot Singh, Brusabhanu Nayak, Haresh KP, Ranjit Kumar Sahoo, Atul Batra
Journal: Journal of Clinical Oncology (2022)

413 Background: Testicular NSGCT is typically diagnosed in young males, and is a highly curable cancer. Data pertaining to the quality of life of testicular NSGCT survivors are limited. Methods: Patients aged 18 or more years with a diagnosis of testicular NSGCT treated in a large tertiary care centre in New Delhi, India between January 2015 and July 2019 were eligible to participate. Patients had to be disease free for at least two years for QoL assessment using EORTC QLQ-C30 questionnaire. Raw scores were transformed as per the EORTC scoring manual. Controls were healthy age-matched adults recruited from the patient accompanying population. Results: We identified 55 survivors and 100 controls. Median age was 32 (range, 18-65) years and 58.2% of patients stage III disease, while the rest were equally divided in stage I and II. Chemotherapy was administered in 94% patients, while 25% had retroperitoneal lymph node resection for residual disease and relapse occurred in 11%, who were treated with salvage chemotherapy and resection of the residual disease. Emotional, social and global scores were significantly lower in survivors as compared to controls. Among symptom scales, fatigue, pain, dyspnoea, insomnia, appetite loss, and financial difficulty were significantly increased in patients as compare to survivors (Table). On a multivariate analysis, neither stage of disease nor treatment were found to be associated significantly with QOL scores. Conclusions: Survivors of testicular NSGCT have lower emotional, social and global functioning and a higher symptom burden. Since NSGCT affects young males, aggressive measures may be needed to improve the QoL in such patients.[Table: see text]
Blood Diversion to the Upper Lobes not due to a Rise in Pulmonary Venous Pressure
Journal: Thorax (1969)

Proceedings of the Thoracic Society occluded pulmonary artery, the saturation fell only in those instances when a pressor response was obtained.On bilateral air injection the degree of unsaturation was quantitatively related to the rise in PA pressure.The saturation fell 6-21 % (average 14-3 %).In six experiments, arterial CO2 pressure changed less than ± 2 mm. Hg.During oxygen breathing, embolization lowered the arterial Po2 from 490 to 399 mm.Hg, corresponding to a shunt of 18 % of the cardiac output.This explains only part of the desaturation during air breathing.
On 'Hospitalism.'
Authors: H. Coote
Journal: BMJ (1869)

THE BRITISH MEDICAL 70URNAL.to bed; if, however, there be anly complication, such as bubo, condy- lomata, etc., the patient is kept in bed so long as necessary.Dr-ess.-The clothes supplied by the hospital consist of a blue serge jacket and skirt, under clotlhing, shoes, and stockings.Hospital flours.-The patients rise at 7 A. WI., breakfast at 8, dine at I o'clock, have tea at 5, and retire to bed at 8 in winter and 9 in summer.Diet.-Break fast consists of bread, six ounces; tea, half a pint.Dinner, of meat (coolked), three ounices; potatoes, half a pound; bread, four ounces; porter, half a pint.Tea consists of bread, six ounces; tea, half a pint.Extras, as wine, beef-tea, eggs, etc., are given at my discretion.Cleanluiess is rigidly enforced.All the women are expected to be properly washed and dressed at IO A. at.Each has a warm bath once a week, unless there be some special reason to the contrary.Occupatio)n.-Theconvalescent patients, in addition to the household work of their vards, do all the needlework required for use throughout the hospital.They wash their own linen weekly; those who are thus employed receiving extra rations.At one time shirt-making was tried, but the work was not performeed satisfactorily.Recreation.-Exercise is allotted to convalescents in the open air for two hours aftcr dinner.For this purpose, an enclosed space adjoining the Lock w-ing has been set apart.Allotment 0I/ tedls.-Whennew-patients are admitted, care is taken
Drug Addiction
Authors: P. Jacobs
Journal: BMJ (1948)

JOURNAinfection in a number of children selected for operation.As Mr. Walker suggests in his final comments, this resolves in the vast majority of cases after removal of the diseased tonsils and adenoids.He considers that the unsatisfactory results following tonsillectomy and adenoidectomy are due to sinusitis: we con- sider that they are more likely to be due to an incorrect selection of children for operation.-Weare, etc., M. R. SHERIDAN.Truro, Cornwall.T. M. BANHAM.Residual Prostatitis SIR,-We have read with great interest Dr. F. C. Bourgault DLI Coudray's excellent article on residual prostatitis (Oct.25, 1947, p. 651).Such a condition has been observed by us in a large number of cases, and assuredly also by many others, after sulphonamide or penicillin treatment of the urethral-process gonorrhoea.Some cases were treated for months and even years with massage, diathermy, and high supplementary doses of antibiotics notwithstanding the fact that repeated cultures of prostatic fluid and of semen were sterile or showed some diph- theroids or Gram-positive cocci or bacilli.Streptomycin was used without success in 2 cases.The persistence of pus cells in the prostatic fluid indicated the existence of an infection whose true nature we have cleared
Medicolegal
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEWS
Authors: P. J. O'DWYER
Journal: JNCI Journal of the National Cancer Institute (1992)

BOOK REVIEWS Get access Handbook of Cancer Chemotherapy, 3rd Edition . Roland T. Skeel , ed. Boston : Little, Brown , 1991 . 549 pp., illus. $29.50 PETER J. O'DWYER, M.D. PETER J. O'DWYER, M.D. Developmental Chemotherapy Fox Chase Cancer Center7701 Burlholme Ave. Philadelphia, PA 19111 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 17, 2 September 1992, Page 1358, https://doi.org/10.1093/jnci/84.17.1358 Published: 02 September 1992
Revisiting the Evolutionary History of Pigs via <i>De Novo</i> Mutation Rate Estimation in a Three-Generation Pedigree
Authors: Mingpeng Zhang, Qiang Yang, Huashui Ai, Lusheng Huang
Journal: Genomics Proteomics & Bioinformatics (2022)

The mutation rate used in the previous analyses of pig evolution and demographics was cursory and hence invited potential bias in inferring evolutionary history. Herein, we estimated the de novo mutation rate of pigs as 3.6 × 10-9 per base per generation using high-quality whole-genome sequencing data from nine individuals in a three-generation pedigree through stringent filtering and validation. Using this mutation rate, we re-investigated the evolutionary history of pigs. The estimated divergence time of ∼ 10 kiloyears ago (KYA) between European wild and domesticated pigs was consistent with the domestication time of European pigs based on archaeological evidence. However, other divergence events inferred here were not as ancient as previously described. Our estimates suggest that Sus speciation occurred ∼ 1.36 million years ago (MYA); European wild pigs split from Asian wild pigs only ∼ 219 KYA; and south and north Chinese wild pigs split ∼ 25 KYA. Meanwhile, our results showed that the most recent divergence event between Chinese wild and domesticated pigs occurred in the Hetao Plain, northern China, approximately 20 KYA, supporting the possibly independent domestication in northern China along the middle Yellow River. We also found that the maximum effective population size of pigs was ∼ 6 times larger than estimated before. An archaic migration from other Sus species originating ∼ 2 MYA to European pigs was detected during western colonization of pigs, which may affect the accuracy of previous demographic inference. Our de novo mutation rate estimation and its consequences for demographic history inference reasonably provide a new vision regarding the evolutionary history of pigs.
Tobacco and Health
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Council on drugs. List No. 90. New names
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Short Notes on the Opinions and Practice of the Late John Pearson, Esq., F.R.S., on Syphilitic Disease
Authors: W. S. Oke
Journal: BMJ (1848)

The urine examined was passed after breakfast, and two hours elapsed before the examination.June 25tb.I insisted upon her leaving her place for a time, ordered her a light mixed diet, slight cathartic, and treated her in the usual way.July lOth.Was discharged well.The oxalate had disappeared, and the quantity of urates and the specific gravity had gradually fallen off.Her catamenia are still absent.These three cases are of the kind most generally met with, yielding readily to treatment and affording another proof of the progress of scientific medicine.In these and all other casesof oxaluriaI have found great mental prostration a constant symptom; it did, not however occur early in the progress of the disease, but succeeded upon a continuance of bodily lassitude and lumbar pain.The appetite was always variable,- sometimes good, at other timues wanting, and more frequently ravenous and unsatisfactory.The lassitude and lumbar pain were constant and invariable symp- toms, and should, Tespecially wheni combined with any hypochondriacal symptoms, raise our suspicions of the presence of the oxalate of lime in the urine.The only satisfactory method of detecting the pre- sence of combinations of oxalic acid in the urine is by the use of the microscope; and as everybody has not a good defining achromatic instrument, it is as *ell to observe that a moderately-powerful chromatic microscope, such as were in fashion twenty years ago, will suffice to detect the peculiar octohedra.I have, when away from home, frequently been obliged to em- ploy one of these usually inefficient instrunients, but have found them answering my purpose.The urine destined for examination may be placed upon a Alip of glass, or in a watch glass, and then heated, to dissolve any crystals of urate of ammionia; or the urine may be filtered through fine blotting paper, which retains the crystals of the oxalate.Distilled water is used to wash these off previously to their being submitted to examination.These are the methods reconmended by Dr. Bird, and, I believe, by Dr. Venables.
Publication of Draft Guidelines for Preventing the Transmission of Tuberculosis in Health-Care Facilities, Second Edition
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Deacetylation of Caveolin-1 by Sirt6 induces autophagy and retards high glucose-stimulated LDL transcytosis and atherosclerosis formation
Authors: Ying Zhao, Xiong Jia, Xiaoyan Yang, Xiangli Bai, Yajing Lu, Lin Zhu, Wenzhuo Cheng, Meng Shu, Yan Zhu, Xiaolong Du, Li Wang, Yan Shu, Yi Song, Si Jin
Journal: Metabolism (2022)

BackgroundAtherosclerosis (AS) is the basis of diabetic macrovascular complications. The plasma low-density lipoprotein (LDL) particles transcytosis across endothelial cells (ECs) and deposition under the endothelium is the initiation step of AS. We previously reported that high glucose inhibits the autophagic degradation of Caveolin-1 and promote LDL transcytosis across ECs, which in turn accelerates atherosclerotic progression. Since Sirt6 is a chromatin-associated protein with deacetylation activity, whether it can regulate Caveolin-1 acetylation and regulating the autophagic degradation of Caveolin-1 remains elusive.MethodsAutophagy and histone acetylation were assessed in the umbilical cords of patients with gestational diabetes mellitus (GDM) by immunohistochemistry. An in vitro model of LDL transcytosis was established, and the role of Sirt6 in LDL transcytosis across endothelial cells was clarified. The effect of Sirt6 on the autophagic degradation of Caveolin-1 under hyperglycemic conditions was explored in a streptozotocin (STZ)-induced diabetic AS model established using the ApoE−/− mice.ResultsCaveolin-1 and acetylated histone H3 levels were significantly increased, while LC3B and Sirt6 were downregulated in the monolayer of the vascular wall from GDM and type 2 diabetes mellitus (T2DM) patients. Immunoprecipitation assays showed that Sirt6 interacts with Caveolin-1 and specifically mediated its acetylation levels. Immuno-electron microscopy (EM) further indicated that Sirt6 overexpression triggered the autophagic lysosomal degradation of Caveolin-1. ECs-specific overexpression of Sirt6 by adeno-associated viral vector serotype 9 (AAV9) induced autophagy, reduced Caveolin-1 expression, and ameliorated atherosclerotic plaque formation in STZ-induced diabetic ApoE−/− mice.ConclusionSirt6-mediated acetylation of Caveolin-1 activates its autophagic degradation and inhibits high glucose-stimulated LDL transcytosis. Thus, the Sirt6/Caveolin-1 autophagic pathway plays a crucial role in diabetic AS, and the overexpression or activation of Sirt6 is a novel therapeutic strategy.
Nerve sparing retroperitoneal lymph node dissection in clinical stage IIA/B seminoma: The COTRIMS trial.
Authors: Axel Heidenreich, Pia Paffenholz, Tim Nestler, David A. Pfister
Journal: Journal of Clinical Oncology (2022)

418 Background: Retroperitoneal radiation therapy or systemic chemotherapy with 3 cycles PEB represent the guideline recommended treatment options in marker negative clinical stage IIA/B seminoma. Despite a high cure rate of 90% to 94% and 82% to 90% in CS IIA and IIB, respectively, both therapeutic options are associated with significant long-term toxicities. It was the aim of our trial to evaluate the feasibility, oncological efficacy and treatment associated morbidity of primary nsRPLND in stage IIA/B seminoma. Methods: 16 patients with marker negative clinical stage IIA and IIB classical seminoma of the testis were recruited in the prospective trial. Patients with primary metastatic stages IIA/B or patients who developed metastatic during active surveillance for clinical stage I seminoma could be recruited. Metastatic disease following carboplatin therapy for clinical stage I seminoma represented an exclusion criteria. Informed consent was obtained after educational talk about the standard treatment options. Surgery associated complications were classified according to Clavien-Dindo. Progression-free survival and overall survival were calculated by Kaplan-Meier curves. Results: Mean age was 37.2 (21-54) years. Mean follow-up is 21.2 (1-36) months. All patients were treatment-naïve and 9 (56.2%) and 7 (43.8%) patients were diagnosed with stage IIA/B at time of primary diagnosis or during active surveillance for clinical stage I disease, respectively. 13 (81.2%) and 3 (18.8%) patients were diagnosed with stage IIA and IIB disease, respectively. 14 (87.5%) and 2 (12.5%) patients underwent open and robot assisted ns RPLND, respectively. Mean OR time was 131 (105-195) min, mean blood loss was &lt; 150ml and the mean hospitalization time was 4.5 (3-9) days. We did not observe surgery associated complications &gt; Clavien Dindo grade 3a. 14/16 (87.5%) patients preserved antegrade ejaculation. Histology of the resected lymph nodes revealed metastatic seminoma in 12 (75%) patients; 1 and 3 patients demonstrated embryonal carcinoma and inflammatory disease, respectively. 2/16 (12.5%) patients developed an outfield relapse 4 and 6 months postoperatively. Both patients were salvaged by systemic chemotherapy with 4 cycles PEB. Conclusions: NsRPLND results in a high cure rate at midterm follow-up and it is associated with a low frequency of treatment associated morbidities making this approach a feasible alternative to standard radiation therapy or systemic chemotherapy. Clinical trial information: DRKS00025384.
A Smart Near‐Infrared Carbon Dot‐Metal Organic Framework Assemblies for Tumor Microenvironment‐Activated Cancer Imaging and Chemodynamic‐Photothermal Combined Therapy
Authors: Yulong Bai, Jingjin Zhao, Liangliang Zhang, Shulong Wang, Jing Hua, Shulin Zhao, Hong Liang
Journal: Advanced Healthcare Materials (2022)

Tumor microenvironment (TME)-activated cancer imaging and therapy is a key to achieving accurate diagnosis and treatment of cancer and reducing the side effects. Herein, smart near-infrared carbon dot-metal organic framework MIL-100 (Fe) assemblies are constructed to achieve TME-activated cancer imaging and chemodynamic-photothermal combined therapy. First, a near-infrared emission carbon dot (RCDs) is developed using glutathione (GSH) as the precursor. Then, the RCDs@MIL-100 self-assemblies are obtained using RCDs, FeCl3 , and trimesic acid solutions as raw materials. After the RCDs@MIL-100 enters the TME, a high concentration of GSH reduces Fe3+ to Fe2+ and drains the GSH, triggering the collapse of RCDs@MIL-100 skeleton and the release of RCDs and Fe2+ , at which time the RCDs fluorescence is restored and in an "on" state to illuminate the tumor cells, which achieved cancer imaging. The released Fe2+ reacts with H2 O2 in the TME to form highly reactive hydroxyl radicals (•OH) by Fenton reaction, which achieves the chemodynamic therapy of tumors. Thus, efficient synergistic chemodynamic-photothermal dual mode therapy is achieved under fluorescence imaging guidance with TME response.
Sex Differences in Myocardial and Vascular Aging
Authors: Hongwei Ji, Alan C. Kwan, Melanie T. Chen, David Ouyang, Joseph E. Ebinger, Susan P. Bell, Teemu J. Niiranen, Natalie A. Bello, Susan Cheng
Journal: Circulation Research (2022)

It is well known that cardiovascular disease manifests differently in women and men. The underlying causes of these differences during the aging lifespan are less well understood. Sex differences in cardiac and vascular phenotypes are seen in childhood and tend to track along distinct trajectories related to dimorphism in genetic factors as well as response to risk exposures and hormonal changes during the life course. These differences underlie sex-specific variation in cardiovascular events later in life, including myocardial infarction, heart failure, ischemic stroke, and peripheral vascular disease. With respect to cardiac phenotypes, females have intrinsically smaller body size-adjusted cardiac volumes and they tend to experience greater age-related wall thickening and myocardial stiffening with aging. With respect to vascular phenotypes, sexual dimorphism in both physiology and pathophysiology are also seen, including overt differences in blood pressure trajectories. The majority of sex differences in myocardial and vascular alterations that manifest with aging seem to follow relatively consistent trajectories from the very early to the very later stages of life. This review aims to synthesize recent cardiovascular aging-related research to highlight clinically relevant studies in diverse female and male populations that can inform approaches to improving the diagnosis, management, and prognosis of cardiovascular disease risks in the aging population at large.