tbuckley/cabot-search huggingface dataset:
DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes
Authors: Anna Maria Sole Giordano, Marco Luciani, Francesca Gatto, Monah Abou Alezz, Chiara Beghè, Lucrezia Della Volpe, Alessandro Migliara, Sara Valsoni, Marco Genua, Monika Dzieciatkowska, Giacomo Frati, Julie Tahraoui-Bories, Silvia Clara Giliani, Simona Orcesi, Elisa Fazzi, Renato Ostuni, Angelo D’Alessandro, Raffaella Di Micco, Ivan Merelli, Angelo Lombardo, Martin A.M. Reijns, Natalia Gromak, Angela Gritti, Anna Kajaste-Rudnitski
Journal: The Journal of Experimental Medicine (2022)

Aberrant induction of type I IFN is a hallmark of the inherited encephalopathy Aicardi-Goutières syndrome (AGS), but the mechanisms triggering disease in the human central nervous system (CNS) remain elusive. Here, we generated human models of AGS using genetically modified and patient-derived pluripotent stem cells harboring TREX1 or RNASEH2B loss-of-function alleles. Genome-wide transcriptomic analysis reveals that spontaneous proinflammatory activation in AGS astrocytes initiates signaling cascades impacting multiple CNS cell subsets analyzed at the single-cell level. We identify accumulating DNA damage, with elevated R-loop and micronuclei formation, as a driver of STING- and NLRP3-related inflammatory responses leading to the secretion of neurotoxic mediators. Importantly, pharmacological inhibition of proapoptotic or inflammatory cascades in AGS astrocytes prevents neurotoxicity without apparent impact on their increased type I IFN responses. Together, our work identifies DNA damage as a major driver of neurotoxic inflammation in AGS astrocytes, suggests a role for AGS gene products in R-loop homeostasis, and identifies common denominators of disease that can be targeted to prevent astrocyte-mediated neurotoxicity in AGS.
EVALUATING THE SAFETY OF RADIAL ACCESS FOR CARDIAC CATHETERIZATION IN END-STAGE RENAL DISEASE (ESRD): EARLY RESULTS FROM THE TRANS-RADIAL ACCESS IN ESRD TRIAL (TRAIN-ESRD)
Authors: Ned Premyodhin, Armen Ghazarian, Kimberly Vu, Emin Zargarian, Michael Johl, Ly-An Dao, Ailin Barseghian El-Farra, Pranav M. Patel, Uttam Reddy, Ihab Bassam Alomari
Journal: Journal of the American College of Cardiology (2022)
Nanoenzyme engineered neutrophil-derived exosomes attenuate joint injury in advanced rheumatoid arthritis via regulating inflammatory environment
Authors: Lei Zhang, Ziguo Qin, Han Sun, Xiang Chen, Jian Dong, Siyu Shen, Liming Zheng, Ning Gu, Qing Jiang
Journal: Bioactive Materials (2022)

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovitis and destruction of cartilage, promoted by sustained inflammation. However, current treatments remain unsatisfactory due to lacking of selective and effective strategies for alleviating inflammatory environments in RA joint. Inspired by neutrophil chemotaxis for inflammatory region, we therefore developed neutrophil-derived exosomes functionalized with sub-5 nm ultrasmall Prussian blue nanoparticles (uPB-Exo) via click chemistry, inheriting neutrophil-targeted biological molecules and owning excellent anti-inflammatory properties. uPB-Exo can selectively accumulate in activated fibroblast-like synoviocytes, subsequently neutralizing pro-inflammatory factors, scavenging reactive oxygen species, and alleviating inflammatory stress. In addition, uPB-Exo effectively targeted to inflammatory synovitis, penetrated deeply into the cartilage and real-time visualized inflamed joint through MRI system, leading to precise diagnosis of RA in vivo with high sensitivity and specificity. Particularly, uPB-Exo induced a cascade of anti-inflammatory events via Th17/Treg cell balance regulation, thereby significantly ameliorating joint damage. Therefore, nanoenzyme functionalized exosomes hold the great potential for enhanced treatment of RA in clinic.
PRE-PROCEDURAL RISK SCORES TO HELP IDENTIFY PATIENTS AT RISK OF CONTRAST INDUCED NEPHROPATHY AFTER CHRONIC TOTAL OCCLUSION PERCUTANEOUS CORONARY INTERVENTION FOR PERI-PROCEDURAL NEPHROPROTECTIVE THERAPIES
Authors: Aram Jamal Mirza, Chuang Gao, Kashan Ali, Samira Bell, Emilie Lambourg, Ify Mordi, Abdulsalam Y. Taha, Shahow A. Ezzaddin, Farhad Huwez, Emily Jefferson, Chim C. Lang
Journal: Journal of the American College of Cardiology (2022)
Abstract PD5-10: Consequent job loss, return to work and multidimensional well-being after breast cancer treatment in working-age black and white women
Authors: Marc A Emerson, Bryce B Reeve, Melissa B. Gilkey, Shekinah N Elmore, Cathy J Bradley, Melissa A Troester
Journal: Cancer Research (2022)

Abstract Background: Few studies have assessed relationships between job loss due to breast cancer and well-being. These relationships may vary by race, work type, and functional difficulties.Methods: In the Carolina Breast Cancer Study, 1,646 women with primary breast cancer who worked prior to diagnosis were longitudinally evaluated for post-diagnosis job loss and well-being using the Functional Assessment of Cancer Therapy General (FACT-G) measure. Women were classified as having ‘sustained work’ (working at baseline and 25 months); ‘returned to work’ (not working at baseline, working at 25 months); ‘consequent job loss’ (working at baseline, not working at 25 months); or ‘persistent non-employment’ (not working at either timepoint). Analysis of covariance was used to evaluate associations between work status and well-being (physical, functional, social, emotional).Results: Women who had sustained work or returned to work had higher FACT-G scores than women with consequent job loss and persistent non-employment in all well-being domains (p&amp;lt;.05). Consequent job loss and persistent non-employment were associated with higher frequency of service/laborer job types, lower education and income, later stage at diagnosis, longer treatment duration, non-private insurance, and greater disability. Consequent job loss was more common among Black than White women (adjusted odds ratio [aOR]=3.44; 95% confidence interval [CI] 2.37-4.99). Black versus White women with job loss reported lower well-being in all domains (p&amp;lt;.05) and greater disability (mean score 42.8 vs. 29.3) and work-related difficulties (aORs=10.3, 95% CI 5.9-18.2 vs. 5.7, 95% CI 2.9-11.2).Conclusions: Work status is an indicator of multidimensional well-being after breast cancer. Citation Format: Marc A Emerson, Bryce B Reeve, Melissa B. Gilkey, Shekinah N Elmore, Cathy J Bradley, Melissa A Troester. Consequent job loss, return to work and multidimensional well-being after breast cancer treatment in working-age black and white women [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr PD5-10.
A Remedy for Professional Unrest
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Nonthermal resection device for ablation of Barrett’s esophagus: a feasibility and safety study
Authors: Annieke W. Gotink, Yonne Peters, Marco J. Bruno, Peter D. Siersema, Arjun D. Koch
Journal: Endoscopy (2022)

Correction to: Nonthermal resection device for ablation of Barrett’s esophagus: a feasibility and safety studyEndoscopy 2022; 54(06): 545-552DOI: 10.1055/a-1644-4326
CARDIOVASCULAR PATIENT OUTCOMES AND COMPLICATIONS AFTER SARS-COV-2 INFECTION
Authors: M. Khodaverdi, Aayush Visaria, Stephanie Hong, Priyal Makwana, Sijin Wen, Wesley Kimble, Scott Chapman, George G. Sokos, Brijesh D. Patel
Journal: Journal of the American College of Cardiology (2022)
EARLY ATRIAL FIBRILLATION RECURRENCE AFTER CATHETER ABLATION IS ASSOCIATED WITH LATE RECURRENCE AND SUBSEQUENT PROCEDURES
Authors: Mark Brahier, Shwetha Kochi, Fengwei Zou, Julia Huang, Athanasios Thomaides, Peter J. Bergquist, Monvadi B. Srichai, Jose D. Vargas
Journal: Journal of the American College of Cardiology (2022)
PATIENT-FACING MHEALTH APPLICATION IMPROVES SELF-CARE AND SYMPTOMS OF HEART FAILURE IN UGANDA
Authors: Jeremy Schwartz, Sahr Wali, Martha Nabadda, Cinderella Ngonzi Muhangi, Ann R. Akiteng, Kaicheng Wang, Rebecca Gillman, J. Lucian Davis, Enock Kibalizi, Nelson Sewankambo, Peter S. Lwabi, Christine Nalwadda, Heather Joan Ross, Joseph Cafazzo, Isaac Ssinabulya
Journal: Journal of the American College of Cardiology (2022)
A META REGRESSION ANALYSIS OF THE ASSOCIATION BETWEEN MEAN AGE AND NUMBER OF BLOOD PRESSURE LOWERING MEDICINES AT BASELINE ON EFFICACY OF RENAL DENERVATION IN SHAM CONTROLLED TRIALS
Authors: Mohammad Ahmed, Matthew Nudy, Rahul Bussa, Alexander Hajduczok, Chad J. Zack, Andrew J. Foy
Journal: Journal of the American College of Cardiology (2022)
HSR22-144: Survival Difference of EGFR Exon 19 Deletion and Exon 21 Mutation in Asian Patients With Advanced Non-small Cell Lung Cancer
Authors: Dawn Lynn P Guardiario, Gerardo H. Cornelio, Raiza S. Marave
Journal: Journal of the National Comprehensive Cancer Network (2022)

"HSR22-144: Survival Difference of EGFR Exon 19 Deletion and Exon 21 Mutation in Asian Patients With Advanced Non-small Cell Lung Cancer" published on 31 Mar 2022 by National Comprehensive Cancer Network.
Immunization with synthetic SARS-CoV-2 S glycoprotein virus-like particles protects macaques from infection
Authors: Guidenn Sulbaran, Pauline Maisonnasse, Axelle Amen, Gregory Effantin, Delphine Guilligay, Nathalie Dereuddre-Bosquet, Judith A. Burger, Meliawati Poniman, Marloes Grobben, Marlyse Buisson, Sebastian Dergan Dylon, Thibaut Naninck, Julien Lemaître, Wesley Gros, Anne-Sophie Gallouët, Romain Marlin, Camille Bouillier, Vanessa Contreras, Francis Relouzat, Daphna Fenel, Michel Thepaut, Isabelle Bally, Nicole Thielens, Franck Fieschi, Guy Schoehn, Sylvie van der Werf, Marit J. van Gils, Rogier W. Sanders, Pascal Poignard, Roger Le Grand, Winfried Weissenhorn
Journal: Cell Reports Medicine (2022)

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused an ongoing global health crisis. Here, we present as a vaccine candidate synthetic SARS-CoV-2 spike (S) glycoprotein-coated lipid vesicles that resemble virus-like particles. Soluble S glycoprotein trimer stabilization by formaldehyde cross-linking introduces two major inter-protomer cross-links that keep all receptor-binding domains in the "down" conformation. Immunization of cynomolgus macaques with S coated onto lipid vesicles (S-LVs) induces high antibody titers with potent neutralizing activity against the vaccine strain, Alpha, Beta, and Gamma variants as well as T helper (Th)1 CD4+-biased T cell responses. Although anti-receptor-binding domain (RBD)-specific antibody responses are initially predominant, the third immunization boosts significant non-RBD antibody titers. Challenging vaccinated animals with SARS-CoV-2 shows a complete protection through sterilizing immunity, which correlates with the presence of nasopharyngeal anti-S immunoglobulin G (IgG) and IgA titers. Thus, the S-LV approach is an efficient and safe vaccine candidate based on a proven classical approach for further development and clinical testing.
EARLY DISSEMINATED LYME CARDITIS COMPLICATED BY PAUSE-DEPENDENT POLYMORPHIC VENTRICULAR TACHYCARDIA LEADING TO CARDIAC ARREST
Authors: Negar Esfandiari, Tanesha Beebe-Peat, Anna Quinlan, Massoud Saleki, Jason Browne, Beth Wagner, Kaileen Cruden, Tyler Wark, Robert Lobel
Journal: Journal of the American College of Cardiology (2022)
If Oral Breathing Does Not Determine Mask Choice for Continuous Positive Airway Pressure Delivery, What Does?
Authors: Dany Jaffuel, Jean Christian Borel
Journal: American Journal of Respiratory and Critical Care Medicine (2022)

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not.The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. If Oral Breathing Does Not Determine Mask Choice for CPAP Delivery, What Does?Dany Jaffuel, Jean Christian Borel
Improving Lagos State emergency medical services by analysing road traffic accident data, response time, and efficient allocation of ambulances
Authors: Sayeed Salam, Avirut Mehta, Dohyeong Kim, Justina Seyi-Olajide, Nicholas Allo, Chenchita Malolan, Fiemu Nwariaku, Latifur Khan
Journal: The Lancet Global Health (2022)

Emergency medical services (EMS) play a critical role in the response to road traffic accidents (RTAs) by providing critical prehospital care to RTA victims, and thus helping to reduce the severity of injuries and casualties from RTAs. Analysing the efficiency of such systems and optimising the service (often with insufficient resources) would be highly beneficial to inform operating guidelines. In this study, we aimed to assess the ambulance utilisation rate for RTAs and provide insights about the system's efficiency and utilisation metrics in Lagos State, Nigeria.We received hospital capacity information (type of hospital [eg, tertiary] and number of beds, nurses, operating rooms, and so on) from hospital survey data in Lagos. Additionally, we received RTA-specific intervention forms from the Lagos State Ambulance Service. With the limited amount of historical data, we highlighted methods to estimate the system parameters (eg, arrival rate, service rate, and so on) of RTA victims at various hospitals in Lagos. We also developed a parametric model and applied approximate dynamic programming approach for ambulance dispatch and location optimisation with a fixed number of base stations. Furthermore, our routing approach was accompanied by directions from OpenRouteService and queue analysis to determine the most appropriate hospital near an RTA for the EMS systems in Lagos.Using patient-queue based wait-time analysis, we found that in over 80% of cases, one of the nearest three hospitals was the most appropriate recommendation for patient delivery. This exponentially decays with the next closest hospitals. Additionally, we found that optimising the ambulance relocation method, where the ambulance returns to a base selected by our model as opposed to its dedicated base or a random base, can reduce the average response time of the EMS system by 8%, or 3·5 min (from 41 min to 38 min).Appropriate placement of mobile resources (ie, ambulances, health-care booths, and so on) can help to lower the response time of EMS systems in addressing RTAs. Similarly, optimal routing of patients to the most well prepared and nearby hospitals would significantly increase the system's efficacy and improve health outcomes. Our findings can provide valuable insight into this and further inform resource allocation and guidelines for health systems, by identifying those hospitals that have the highest burden of RTA victims and those that provide the most efficient care in a resource-limited setting.National Institutes of Health (1R21TW010991-01A1).
EPICARDIAL ADIPOSE TISSIE-DERIVED LEPTIN INDUCE MMPS/TIMPS IMBALANCE AND PROMOTE CARDIAC FIBROSIS THROUGH JAK2/ROS/NA/K-ATPASE/ERK1/2 SIGNALING PATHWAY IN HIGH FAT DIET-INDUCED OBESE RATS
Authors: Gang Tian, Chaodi Luo, Lei Liu
Journal: Journal of the American College of Cardiology (2022)
Inhalation of MSC-EVs is a noninvasive strategy for ameliorating acute lung injury
Authors: Ruijing Zhao, Lina Wang, Tian Wang, Panpan Xian, Hongkang Wang, Qianfa Long
Journal: Journal of Controlled Release (2022)

Mesenchymal stem cell-derived small extracellular vesicles (MSC-EVs) are promising nanotherapeutic agent for pneumonia (bacterial origin, COVID-19), but the optimal administration route and potential mechanisms of action remain poorly understood. This study compared the administration of MSC-EVs via inhalation and tail vein injection for the treatment of acute lung injury (ALI) and determined the host-derived mechanisms that may contribute to the therapeutic effects of MSC-EVs in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells (macrophage cell line) and animal models. Luminex liquid chip and hematoxylin and eosin (HE) staining revealed that, compared with the vehicle control, inhaled MSC-EVs outperformed those injected via the tail vein, by reducing the expression of pro-inflammatory cytokines, increasing the expression of anti-inflammatory cytokine, and decreasing pathological scores in ALI. MSC-EV administration promoted the polarization of macrophages towards a M2 phenotype in vitro and in vivo (via inhalation). RNA sequencing revealed that immune and redox mediators, including TLR4, Arg1, and HO-1, were associated with the activity MSC-EVs against ALI mice. Western blotting and immunofluorescence revealed that correlative inflammatory and oxidative mediators were involved in the therapeutic effects of MSC-EVs in LPS-stimulated cells and mice. Moreover, variable expression of Nrf2 was observed following treatment with MSC-EVs in cell and animal models, and knockdown of Nrf2 attenuated the anti-inflammatory and antioxidant activities of MSC-EVs in LPS-stimulated macrophages. Together, these data suggest that inhalation of MSC-EVs as a noninvasive strategy for attenuation of ALI, and the adaptive regulation of Nrf2 may contribute to their anti-inflammatory and anti-oxidant activity in mice.
MZ Alpha-1 Antitrypsin Deficiency
Authors: Oliver J McElvaney, Gerald Finnerty, Tomás P Carroll, Mark L Brantly, Noel G McElvaney
Journal: American Journal of Respiratory and Critical Care Medicine (2022)

"MZ Alpha-1 Antitrypsin Deficiency." American Journal of Respiratory and Critical Care Medicine, 205(7), pp. P13–P14
PATTERNS OF PHYSICAL FRAILTY AND COGNITIVE IMPAIRMENT IN OLDER ADULTS AT RISK FOR CARDIOVASCULAR DISEASE IN THE NATIONAL HEALTH AND AGING TRENDS STUDY (NHATS)
Authors: Naila Ijaz, Shang-En Chung, Qian-Li Xue, David Roth, Mauro Moscucci, Daniel E. Forman, Karen Badeen-Roche, Wayne B. Batchelor, Jeremy Walston, Jon R. Resar, Gary Gerstenblith, Abdulla Damluji
Journal: Journal of the American College of Cardiology (2022)
Abstract P2-12-10: Improving pathological complete response in luminal breast cancer after neoadjuvant chemotherapy
Authors: Ariadna Gasol Cudós, Serafin Morales Murillo, Alvaro Rodriguez Galindo, Ona Pallisé Subirats, Jordi Melé Olivé, Carles Canosa Morales, Felip vilardell villellas, Douglas René Sanchez Guzman, Joel Veas Rodriguez
Journal: Cancer Research (2022)

Abstract Pathological complete response to neoadjuvant chemotherapy in luminal breast cancer is extremely low so its role is very controversial. We investigated whether the use Oncotype DX recurrence score ® could improve this response.We performed the Oncotype Dx in 103 patients with early breast cancer with high-risk clinical criteria to receive neoadjuvant chemotherapy. We reported the pathologic complete response (pCR) and its association with Oncotype DX.Median age was of 51 (24-87), median tumor size of 26 mm and 51 (57%) patients had initial node involvement. Median estrogen and progesterone receptor by histoscore was 280 and 40 and median Ki67 value was 30. 50 patients were less than 50 years old. Median Oncotype score was 30 (12-76) and 15 (14,6%) in the 11-18 score interval, 21 (20,4%) in the 18-25 and 67 (65%) with a score greater than 25. 24 (23,3%) patients obtained pCR, 22% in initial node involvement and 25% in not nodal involvement.The Oncotype DX its highly correlated with pCR (OD: 1,059, p: 0,004) in the multivariable analysis and in patients with Oncotype DX RS≥25 there was a strong correlation (OD: 18,295, P:0,005). pCR according with age (less or more than 50) and Oncotype Dx interval score is reported in the table. Conclusion: Oncotype DX recurrence score ® predicts with great accuracy the pathologic complete response. Patients with RS 11-25 had a very low pCR, whereas patients with RS&amp;gt;25 achieve a 34% of pCR. Based on initial considered High risk Score (&amp;gt;31) we achieve a total of 18 to 42 patients of pCR (42%). Oncotype DX recurrence score ® allows a very considerable increase in the complete pathological responses after neoadjuvant chemotherapy, so it should be considered when selecting the patients who should receive neoadjuvant chemotherapy. LESS THAN 50 YEARSMORE THAN 50 YEARSONCOTYPETOTALpCRTOTALpCRRS 11-18100 (0%)50 (0%)RS 18-25101 (10%)110 (0%)RS &amp;gt; 253011(36%)3712 (32%) Citation Format: Ariadna Gasol Cudós, Serafin Morales Murillo, Alvaro Rodriguez Galindo, Ona Pallisé Subirats, Jordi Melé Olivé, Carles Canosa Morales, Felip vilardell villellas, Douglas René Sanchez Guzman, Joel Veas Rodriguez. Improving pathological complete response in luminal breast cancer after neoadjuvant chemotherapy [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P2-12-10.
BIO22-030: E2F1: A Potential Prognostic Biomarker and Therapeutic Target by Affecting Tumor Development and Immune Microenvironment in LIHC
Authors: Zhibo Tan, Min Chen, Feng Peng, Pengfei Yang, Zhaoming Peng, Xin Li, Xiaopeng Zhu, Yujie Zhao, Yajie Liu
Journal: Journal of the National Comprehensive Cancer Network (2022)

"BIO22-030: E2F1: A Potential Prognostic Biomarker and Therapeutic Target by Affecting Tumor Development and Immune Microenvironment in LIHC" published on 31 Mar 2022 by National Comprehensive Cancer Network.