tbuckley/cabot-search huggingface dataset:
QUANTITATIVE ASSESSMENT OF CONTRAST ENHANCED ENDOSCOPIC ULTRASONOGRAPHY (CE-EUS) WASHOUT RATE IN PREDICTING MALIGNANCY IN PANCREATIC SOLID MASSES: A PILOT STUDY
Authors: V. Rednic, C. Cioltean, R. Orzan, A. Spulber, C. Pojoga, O. Mosteanu, C. Hagiu, I. Rusu, A. Seicean
Journal: Endoscopy (2022)

Aims Contrast enhanced endoscopic ultrasound (CE-EUS) is a sensitive method to evaluate pancreatic solid masses. The arterial phase was mostly studied, however, the importance of venous wash-out has been less studied.
THE RELATIONSHIP BETWEEN PORTAL HYPERTENSIVE GASTROPATHY AND GASTROESOPHAGEAL VARICES
Authors: R. Tababi, S. Mrabet, A. Hassine, R. Harbi, I. Akkari, A. Hassine, E. Ben Jazia
Journal: Endoscopy (2022)

Aims So far, the connection linking portal hypertensive gastropathy (PHG) and other endoscopic portal hypertension signs is still unclear. Our study aimed to determine the correlation between PHG and oesophageal varices (OV) as well as gastric varices (GV).
CXCL14 Promotes a Robust Brain Tumor-Associated Immune Response in Glioma
Authors: Anupam Kumar, Esraa Mohamed, Schuyler Tong, Katharine Chen, Joydeep Mukherjee, Yunita Lim, Cynthia M. Wong, Zoe Boosalis, Anny Shai, Russell O. Pieper, Nalin Gupta, Arie Perry, Andrew W. Bollen, Annette M. Molinaro, David A. Solomon, Joseph T.C. Shieh, Joanna J. Phillips
Journal: Clinical Cancer Research (2022)

Abstract Purpose: The immunosuppressive tumor microenvironment present in the majority of diffuse glioma limits therapeutic response to immunotherapy. As the determinants of the glioma-associated immune response are relatively poorly understood, the study of glioma with more robust tumor-associated immune responses may be particularly useful to identify novel immunomodulatory factors that can promote T-cell effector function in glioma. Experimental Design: We used multiplex immune-profiling, proteomic profiling, and gene expression analysis to define the tumor-associated immune response in two molecular subtypes of glioma and identify factors that may modulate this response. We then used patient-derived glioma cultures and an immunocompetent murine model for malignant glioma to analyze the ability of tumor-intrinsic factors to promote a CD8+ T-cell response. Results: As compared with isocitrate dehydrogenase (IDH)-mutant astrocytoma, MAPK-activated pleomorphic xanthoastrocytoma (PXA) harbored increased numbers of activated cytotoxic CD8+ T cells and Iba1+ microglia/macrophages, increased MHC class I expression, enrichment of genes associated with antigen presentation and processing, and increased tumor cell secretion of the chemokine CXCL14. CXCL14 promoted activated CD8+ T-cell chemotaxis in vitro, recruited tumor-infiltrating CD8+ T cells in vivo, and prolonged overall survival in a cytotoxic T-cell–dependent manner. The immunomodulatory molecule B7-H3 was also highly expressed in PXA. Conclusions: We identify the MAPK-activated lower grade astrocytoma PXA as having an immune-rich tumor microenvironment and suggest this tumor may be particularly vulnerable to immunotherapeutic modulation. We also identify CXCL14 as an important determinant of the glioma-associated immune microenvironment, sufficient to promote an antitumor CD8+ T-cell response.
ATYPICAL INTESTINAL ANASTOMOSES (AIA) USING LUMEN APPOSING STENTS IN UNUSUAL CLINICAL SITUATIONS: A MINIMALLY INVASIVE EXTENSION OF EUS-GUIDED GASTRO-JEJUNAL ANASTOMOSES (GJA)
Authors: J.-M. Gonzalez, M. Gasmi, M. Barthet
Journal: Endoscopy (2022)

We report 4 cases of atypical EUS-guided intestinal anastomoses (AIA) using LAMS. The indications were: gastro-jejunal anastomosis with biliary limb after pancreatoduodenectomy for ERCP access for hilar obstruction; Jejuno-jejunal anastomosis for Candy-cane syndrome after gastrectomy; Ileo-colic anastomoses (2) for small bowel occlusion due to peritoneal carcinomatosis.
Evolution, Expression Patterns, and Distribution of Novel Ribbon Worm Predatory and Defensive Toxins
Authors: Aida Verdes, Sergi Taboada, Brett R. Hamilton, Eivind A.B. Undheim, Gabriel G. Sonoda, Sonia C.S. Andrade, Esperanza Morato, Ana Isabel Marina, César A. Cárdenas, Ana Riesgo
Journal: Molecular Biology and Evolution (2022)

Abstract Ribbon worms are active predators that use an eversible proboscis to inject venom into their prey and defend themselves with toxic epidermal secretions. Previous work on nemertean venom has largely focused on just a few species and has not investigated the different predatory and defensive secretions in detail. Consequently, our understanding of the composition and evolution of ribbon worm venoms is still very limited. Here, we present a comparative study of nemertean venom combining RNA-seq differential gene expression analyses of venom-producing tissues, tandem mass spectrometry-based proteomics of toxic secretions, and mass spectrometry imaging of proboscis sections, to shed light onto the composition and evolution of predatory and defensive toxic secretions in Antarctonemertes valida. Our analyses reveal a wide diversity of putative defensive and predatory toxins with tissue-specific gene expression patterns and restricted distributions to the mucus and proboscis proteomes respectively, suggesting that ribbon worms produce distinct toxin cocktails for predation and defense. Our results also highlight the presence of numerous lineage-specific toxins, indicating that venom evolution is highly divergent across nemerteans, producing toxin cocktails that might be finely tuned to subdue different prey. Our data also suggest that the hoplonemertean proboscis is a highly specialized predatory organ that seems to be involved in a variety of biological functions besides predation, including secretion and sensory perception. Overall, our results advance our knowledge into the diversity and evolution of nemertean venoms and highlight the importance of combining different types of data to characterize toxin composition in understudied venomous organisms.
LONG-TERM OUTCOMES OF ENDOSCOPIC PAPILLARY BALLOON DILATION FOR 8-12MM BILE DUCT STONES: A PROSPECTIVE STUDY
Authors: D. Arna, M. Velegraki, P. Nicolaou, A. Psistakis, A. Mpitouli, M. Fragaki, V. Papastergiou, E. Vardas, G. Paspatis
Journal: Endoscopy (2022)

Aims Stone recurrence is a significant long-term complication after endoscopic papillary balloon dilation (EPBD) with endoscopic sphincterotomy (EST) for large or difficult common bile duct (CBD) stones. However, data on long-term outcomes after EPBD+EST for CBD stones up to 8-12mm remain limited. We prospectively evaluated long-term outcomes of ELBPD+EST for CBD stones up to 8-12mm.
ENDOSCOPIC MANAGEMENT OF LATERALLY SPREADING LESIONS OF THE RECTUM INCLUDING THE ANO-RECTAL JUNCTION: A SINGLE CENTRE EXPERIENCE
Authors: E.M. McCarthy, J. Leyden, S. King, C. Lahiff
Journal: Endoscopy (2022)

Aims Endoscopic mucosal resection (EMR) is an established therapy for removing laterally spreading lesions of the rectum. The optimal therapy for removing anorectal junction LSLS (ARJ-LSLs) is unknown but use of EMR is supported by prospective observational data. Our aim was to complete a single centre review of clinical outcomes for rectal and ARJ-LSLs managed endoscopically over a four-year period
Effectiveness of Ad26.COV2.S and BNT162b2 Vaccines against Omicron Variant in South Africa
Authors: Glenda Gray, Shirley Collie, Ameena Goga, Nigel Garrett, Jared Champion, Ishen Seocharan, Lesley Bamford, Harry Moultrie, Linda-Gail Bekker
Journal: New England Journal of Medicine (2022)
Arginine‐Rich Polymers with Pore‐Forming Capability Enable Efficient Intracellular Delivery via Direct Translocation Across Cell Membrane
Authors: Ziyao Kang, Qi Liu, Zhanzhan Zhang, Yadan Zheng, Chun Wang, Zheng Pan, Qiushi Li, Yang Liu, Linqi Shi
Journal: Advanced Healthcare Materials (2022)

Abstract Efficient delivery of biomacromolecules or drugs across the cell membrane via endocytosis usually encounters inevitable entrapment in endosomes and subsequent degradation in lyso‐endosomes. To address this issue, a series of arginine‐rich cell penetrating polymers is designed and synthesized, which internalize into cells by inducing the formation of pores on the cell membrane, thereby crossing the cell membrane via direct translocation that fundamentally avoids endo/lysosomal entrapment. The structure−activity relationship studies show that PTn‐R2‐C6, which is a type of polymer that has two arginine residues and a flexible hexanoic acid linker in each side chain, exhibits excellent pore‐formation ability on the cell membrane. Further investigations indicate that PTn‐R2‐C6 rapidly transports plasmid DNAs into cytosol through a similar endocytosis‐independent pathway, thereby achieving significantly higher transfection efficiency and lower cytotoxicity than the gold‐standard transfection reagent PEI 25K. These results suggest the great potential of PTn‐R2‐C6 as a safe and efficient gene transfection reagent for wide applications including disease treatments, vaccine development, and biomedical research purposes.
185P Long-term efficacy of trastuzumab biosimilar CT-P6 in patients with HER2-positive early breast cancer: 6-year survival analysis of phase III study results
Authors: J. Stebbing, Y. Baranau, V. Baryash, V. Moiseyenko, D. Boliukh, N.Z. Antone, A. Manikhas, A. Chornobai, S.H. Kim, K. Ahn, T. Park, E.H. Baek, S. Park, S.J. Lee, I.S. Chang, S.H. Kim, J.Y. Lee, J.I. Choi
Journal: Annals of Oncology (2022)
ANALYSIS OF THE EUS-GUIDED RENDEZVOUS TECHNIQUE IN BILIOPANCREATIC DRAINAGE: HISTORICAL COHORT
Authors: A. Garcia-Sumalla, S. Quintana, D. Luna-Rodriguez, J. Busquets, M. Marin, B. Laquente, J. Fabregat, J.B. Gornals
Journal: Endoscopy (2022)

Aims The rendezvous technique (RV) has been described as a rescue method in cases of difficult biliopancreatic access by the usual method (transpapillary-ERCP). Current literature remains unclear regarding its efficacy and safety.
NOVEL TECHNIQUE TO INSERT LARGE CALIBER SELF-EXPANDING METAL STENTS DURING BALLOON-OVERTUBE ENTEROSCOPY (BAE)-ASSISTED ERCP
Authors: K. Mönkemüller, T. Kröner, A. Martínez-Alcalá
Journal: Endoscopy (2022)

When performing device-assisted-ERCP the ability to place large caliber plastic stents or fully-covered self-expanding-metal stents (SEMS) is limited because the working channel of the scope is too narrow and will not allow passage of these devices and utensils. Our technique consists of utilizing the overtube as a “giant working channel”, inserting a wire into the bile ducts, removing the scope, and then inserting the self-expanding-metal-stent over-the-wire, through the overtube under fluoroscopic control. In addition, the overtube may be left in situ to allow for insertion of standard or ultraslim scopes to perform direct cholangioscopy, laser lithotripsy and stone removal.
CHARLSON COMORBIDITY INDEX PREDICTS COLONIC DIVERTICULAR REBLEEDING
Authors: H.-S. You, D.H. Kim, S.-Y. Park
Journal: Endoscopy (2022)

Aims Colonic diverticular bleeding (CDB) is a common cause of acute lower gastrointestinal bleeding. Patients with CDB are at increased risk for recurrence. Here, we aimed to evaluate the clinical course of patients with CDB and identify risk factors including Charlson comorbid index (CCI) for recurrent CDB (rCDB).
SAFETY AND EFFECTIVENESS OF ENDOSCOPIC SAVARY-GILLIARD DILATOR IN PATERSON-BROWN-KELLY SYNDROME PATIENTS
Authors: L. Chtourou, H. Smaoui, O. Khrouf, R. Kallel, H. Gdoura, M. Boudabbous, L. Mnif, A. Amouri, N. Tahri
Journal: Endoscopy (2022)

Aims Paterson-Brown-Kelly syndrome (PBKS) is a rare entity characterized by iron-deficiency anemia, dysphagia, and upper esophageal webs. Treatment consists of mechanical dilation and iron supplementation. The aim of the study was to evaluate safety and effectiveness of Savary-Gilliard bougies dilation for the treatment of PBKS.
An Atypical Form of Diabetes Among Individuals With Low BMI
Authors: Eric Lontchi-Yimagou, Riddhi Dasgupta, Shajith Anoop, Sylvia Kehlenbrink, Sudha Koppaka, Akankasha Goyal, Padmanaban Venkatesan, Roshan Livingstone, Kenny Ye, Aaron Chapla, Michelle Carey, Arun Jose, Grace Rebekah, Anneka Wickramanayake, Mini Joseph, Priyanka Mathias, Anjali Manavalan, Mathews Edatharayil Kurian, Mercy Inbakumari, Flory Christina, Daniel Stein, Nihal Thomas, Meredith Hawkins
Journal: Diabetes Care (2022)

OBJECTIVE Diabetes among individuals with low BMI (&amp;lt;19 kg/m2) has been recognized for &amp;gt;60 years as a prevalent entity in low- and middle-income countries (LMICs) and was formally classified as “malnutrition-related diabetes mellitus” by the World Health Organization (WHO) in 1985. Since the WHO withdrew this category in 1999, our objective was to define the metabolic characteristics of these individuals to establish that this is a distinct form of diabetes. RESEARCH DESIGN AND METHODS State-of-the-art metabolic studies were used to characterize Indian individuals with “low BMI diabetes” (LD) in whom all known forms of diabetes were excluded by immunogenetic analysis. They were compared with demographically matched groups: a group with type 1 diabetes (T1D), a group with type 2 diabetes (T2D), and a group without diabetes. Insulin secretion was assessed by C-peptide deconvolution. Hepatic and peripheral insulin sensitivity were analyzed with stepped hyperinsulinemic-euglycemic pancreatic clamp studies. Hepatic and myocellular lipid contents were assessed with 1H-nuclear magnetic resonance spectroscopy. RESULTS The total insulin secretory response was lower in the LD group in comparison with the lean group without diabetes and the T2D group. Endogenous glucose production was significantly lower in the LD group than the T2D group (mean ± SEM 0.50 ± 0.1 vs. 0.84 ± 0.1 mg/kg · min, respectively; P &amp;lt; 0.05). Glucose uptake was significantly higher in the LD group in comparison with the T2D group (10.1 ± 0.7 vs. 4.2 ± 0.5 mg/kg · min; P &amp;lt; 0.001). Visceral adipose tissue and hepatocellular lipids were significantly lower in LD than in T2D. CONCLUSIONS These studies are the first to demonstrate that LD individuals in LMICs have a unique metabolic profile, suggesting that this is a distinct entity that warrants further investigation.
ENDOSCOPIC VACUUM THERAPY FOR PATIENTS WITH ESOPHAGEAL PERFORATION: A MULTI-CENTER RETROSPECTIVE COHORT STUDY
Authors: J. Luttikhold, L.M.D. Pattynama, S. Seewald, S. Groth, B. Morell, W.J. Eshuis, R.E. Pouw
Journal: Endoscopy (2022)

Aims Esophageal perforations, due to vomiting (Boerhaave syndrome) or iatrogenic cause, are associated with high morbidity and mortality. Recently, endoscopic vacuum therapy (EVT) was introduced as new treatment option for esophageal perforations. The aim of this study was to describe outcomes of initial experiences with EVT for treatment of these perforations.
AN INTRACOLONOSCOPY BOWEL CLEANSING SYSTEM FOR HARD-TO-PREPARE PATIENTS – A PROSPECTIVE MULTICENTER STUDY
Authors: M. van Riswijk, K. van Keulen, H. Neumann, P. Siersema
Journal: Endoscopy (2022)

Aims Adequate bowel preparation (BP) is essential for the efficacy and safety of colonoscopy. However, inadequate BP is reported in approximately 20% of colonoscopies, despite intensified regimes. Therefore, we hypothesized that an intraprocedural bowel cleansing system (Pure-Vu System, MotusGI) could fill this gap in BP strategies for hard-to-prepare patients. This study aims to assess the feasibility of the Pure-Vu in patients with a history of poor BP for colonoscopy.
IMPACT OF THE PANDEMIC COVID-19 ON DIGESTIVE ENDOSCOPIC ACTIVITY
Authors: A. Sair, S. Mrabti, A. Benhamdane, T. Addajou, M. Osman, R. Berraida, S. Sentissi, I. Elkoti, F. Rouibaa, A. Benkirane, H. Seddik
Journal: Endoscopy (2022)

Aims in order to prepare health facilities for the upcoming influx of COVID-19 patients, it was necessary to minimize non-COVID-19 related activities, which led to a significant reduction of non-urgent procedures.
RESCUE ENTERO-ENTEROSTOMY WITH A SELF-EXPANDABLE METAL STENT (SEMS) AFTER A FAILED DEPLOYMENT OF A LUMEN-APPOSING METAL STENT (LAMS): IDENTIFY THE DIRECTION OF BOWEL TRANSIT IS KEY!
Authors: V. Busto, S. Bravo, M. Ganuza, P. Salmón, A. Arrubla, I. Rodríguez, I. Aresté, L. Uribarri, F. Estremera, J.J. Vila
Journal: Endoscopy (2022)

A 40 year-old woman with acute pancreatitis requiring several abdominal surgeries presented with an ileo-cutaneous fistula.
TO RESEARCH THE RELATIONSHIP BETWEEN THE PERCENTAGE OF OVERSPEED OF COLONOSCOPY WITHDRAWAL AND THE ADENOMA DETECTION RATE
Authors: R. Gong, L. Yao, S. Hu, H. Yu
Journal: Endoscopy (2022)

Aims Colonoscopy can reduce the incidence of colorectal cancer by detecting and resecting precancerous lesions such as adenomas. The existing evidence shows that the quality of colonoscopy varies from different endoscopists and the adenoma detection rate varies from 7.2% to 52.3% . Therefore, the purpose of this study was to research the relationship between the percentage of overspeed of colonoscopy withdrawal and the adenoma detection rate through prospectively collected colonoscopy videos, so as to guide the practice of endoscopists and improve the adenoma detection rate.
ENDOSCOPIC ULTRASOUND-GUIDED CHOLECYSTOSTOMY VERSUS PERCUTANEOUS CHOLECYSTOSTOMY IN THE TREATMENT OF ACUTE CHOLECYSTITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: M. Candido Hemerly, P. Henrique Boraschi Vieira Ribas, V. Lira de Oliveira, E. Yuki Yvamoto, I. Mendonça Proença, E. Silvino do Monte Junior, W. Marques Bernardo, D. Turiani Hourneaux de Moura, E. Guimarães Hourneaux de Moura
Journal: Endoscopy (2022)

Aims Surgical cholecystectomy is the gold standard strategy for treatment of Acute cholecystitis (AC). However, some patients are considered unfit for surgery due to their clinical conditions. As such, we sought to compare endoscopic ultrasound-guided galbladder drainage (EUSGBD) versus percutaneous galbladder drainage (PTGBD) for patients with AC unfit for surgical approach.
A NOVEL ONE-DAY VIRTUAL-LIVE HYBRID TRAINING COURSE IS FEASIBLE AND HAS A POSITIVE IMPACT ON COLONOSCOPY KEY PERFORMANCE INDICATORS OF EXPERIENCED ENDOSCOPY TRAINEES
Authors: L. Krott, L. Debels, C. Schoonjans, J. Anderson, R. Valori, L. Desomer, D. Tate
Journal: Endoscopy (2022)

Aims Colonoscopy is a complex practical skill and highly operator dependent. The consistent attainment of key performance indicators (KPIs) depends primarily upon training. Training can be unstructured and contingent upon the observed practice of a small number of trainers. We sought to demonstrate the feasibility and impact of a one-day virtual-live colonoscopy-training course with remote, experienced trainers.
SYSTEMATIC TRACEABILITY MONITORING IN DIGESTIVE ENDOSCOPY : A QUALITY STANDARD ?
Authors: S. Belkhir, M. Gerard, W. Ambrocio, P. Eisendrath
Journal: Endoscopy (2022)

Aims Traceability of reprocessing process in digestive endoscopy is essential to ensure retrospective investigation in case of contamination accident. Regular evaluation of facilities, including disinfection procedures, is recommended by ESGE in their Quality improvement initiative program. Therefore, traceability adequacy should be considered as a quality indicator. We report here the development of an automated traceability monitoring system, based on an electronic documentation system.
RISK OF POST-ERCP PANCREATITIS AFTER DOUBLE-GUIDEWIRE TECHNIQUE FOR DIFFICULT BILIARY CANNULATION
Authors: Y. Myung, J. Han, S. Lee, K.j. Han
Journal: Endoscopy (2022)

Aims Although double-guidewire technique (DGT) is useful for difficult biliary cannulation, this technique has the potential risk of post-ERCP pancreatitis(PEP). The objective of this study was to clarify the incidence and risk factors of PEP after DGT for difficult biliary cannulation.
106P Subsets of circulating tumor cells in breast cancer patients treated by neoadjuvant chemotherapy
Authors: E. Grigoryeva, O.E. Savelieva, L. Tashireva, V.V. Alifanov, M.V. Zavyalova, N.A. Tarabanovskaya, N. Cherdyntseva, V.M. Perelmuter
Journal: Annals of Oncology (2022)
LONG TERM EFFICIENCY OF EUS GUIDED BILIARY DRAINAGE USING ELECTROCAUTERY ENHANCED LAMS IN CASE OF FAILED ERCP, A LARGE PROSPECTIVE STUDY OF 118 CASES
Authors: J. Albouys, B. Redelsperger, R. Legros, H. Lepetit, M. Dahan, R. Rodrigues, C. Brule, S. Geyl, J. Jacques
Journal: Endoscopy (2022)

Aims EC-LAMS allows EUS guided choledocoduodenostomy in a single step, without prior bile duct puncture or the need for a guidewire when ERCP fails or is unfeasible.
Association of AZD1222 and BNT162b2 COVID-19 Vaccination With Thromboembolic and Thrombocytopenic Events in Frontline Personnel
Authors: Anders Hviid, Jørgen Vinsløv Hansen, Emilia Myrup Thiesson, Jan Wohlfahrt
Journal: Annals of Internal Medicine (2022)

In March 2021, several European countries suspended the use of the AZD1222 (Oxford-AstraZeneca) COVID-19 vaccine because of thromboembolic safety concerns. Reports from Norway and Germany subsequently described patients with venous thrombosis and thrombocytopenia within 5 to 16 days of vaccination.To evaluate the risk for outcomes related to thrombosis and thrombocytopenia after AZD1222 or BNT162b2 (Pfizer-BioNTech) COVID-19 vaccination.Nationwide exploratory retrospective cohort study.Danish linkable registers on vaccinations, hospitalizations, occupation, and other covariates.355 209 Danish frontline personnel designated for priority COVID-19 vaccination followed from 27 December 2020 (the day of the first COVID-19 vaccination in Denmark) to 13 April 2021.Study outcomes were cerebral venous sinus thrombosis, splanchnic vein thrombosis, pulmonary embolism, deep venous thrombosis, arterial thrombosis, thrombocytopenia, and death. Cumulative incidences of study outcomes within 28 days of vaccination and unvaccinated risk time were compared using adjusted survival curves resulting in risk differences (RDs) at day 28 after vaccination. Adjustment for birth cohort, sex, calendar period, occupation, comorbid conditions, and prescription drug use was included.Vaccination with AZD1222 versus no vaccination was associated with a significant RD at day 28 for deep venous thrombosis (RD, 8.35 [95% CI, 0.21 to 16.49] per 100 000 vaccinations). The RDs for cerebral venous sinus thrombosis (RD, 1.68 [CI, -0.64 to 4.00] per 100 000 vaccinations) and thrombocytopenia (RD, 2.39 [CI, -1.09 to 5.87] per 100 000 vaccinations) were not significant. No adverse associations were seen for BNT162b2 vaccination.No medical record review; surveillance bias.In this exploratory retrospective cohort study among frontline personnel in Denmark, receipt of the AZD1222 vaccine was associated with a small excess risk for deep venous thrombosis. Although the corresponding risks for the more rare and severe thrombotic outcomes (such as cerebral venous sinus thrombosis) were not statistically significantly increased, statistical precision was low, and clinically relevant risks could not be excluded with certainty. There was no statistically significant association of BNT162b2 vaccination with thrombotic or thrombocytopenic events.Lundbeck Foundation.