tbuckley/cabot-search huggingface dataset:
<scp>Layer‐specific</scp> global longitudinal strain and the risk of heart failure and cardiovascular mortality in the general population: the Copenhagen City Heart Study
Authors: Kristoffer Grundtvig Skaarup, Mats C.H. Lassen, Niklas D. Johansen, Morten Sengeløv, Jacob L. Marott, Peter G. Jørgensen, Gorm Jensen, Peter Schnohr, Eva Prescott, Peter Søgaard, Gunnar Gislason, Rasmus Møgelvang, Tor Biering‐Sørensen
Journal: European Journal of Heart Failure (2021)
Bcr-Abl1 Kinase-Independent Upregulation of FcγRIIb Mediates Malignant Signaling That Is Critical for Leukemogenesis
Authors: Oliver Herrmann, Samantha Langer, Caroline Wessling, Michael Huber, Shaoguang Li, Tim Henrik Bruemmendorf, Steffen Koschmieder, Mirle Schemionek
Journal: Blood (2017)
Ascaris lumbricoides and ticks associated with sensitization to galactose α1,3-galactose and elicitation of the alpha-gal syndrome
Authors: Tatenda Murangi, Prema Prakash, Bernardo Pereira Moreira, Wisdom Basera, Maresa Botha, Stephen Cunningham, Heidi Facey-Thomas, Ali Halajian, Lokesh Joshi, Jordache Ramjith, Franco H. Falcone, William Horsnell, Michael E. Levin
Journal: Journal of Allergy and Clinical Immunology (2021)
Awake prone positioning and oxygen therapy in patients with COVID-19: the APRONOX study
Authors: Orlando R. Perez-Nieto, Diego Escarraman-Martinez, Manuel A. Guerrero-Gutierrez, Eder I. Zamarron-Lopez, Javier Mancilla-Galindo, Ashuin Kammar-García, Miguel A. Martinez-Camacho, Ernesto Deloya-Tomás, Jesús S. Sanchez-Díaz, Luis A. Macías-García, Raúl Soriano-Orozco, Gabriel Cruz-Sánchez, José D. Salmeron-Gonzalez, Marco A. Toledo-Rivera, Ivette Mata-Maqueda, Luis A. Morgado-Villaseñor, Jenner J. Martinez-Mazariegos, Raymundo Flores Ramirez, Josue L. Medina-Estrada, Silvio A. Ñamendys-Silva
Journal: European Respiratory Journal (2021)

The awake prone positioning strategy for patients with acute respiratory distress syndrome is a safe, simple and cost-effective technique used to improve hypoxaemia. We aimed to evaluate intubation and mortality risk in patients with coronavirus disease 2019 (COVID-19) who underwent awake prone positioning during hospitalisation.In this retrospective, multicentre observational study conducted between 1 May 2020 and 12 June 2020 in 27 hospitals in Mexico and Ecuador, nonintubated patients with COVID-19 managed with awake prone or awake supine positioning were included to evaluate intubation and mortality risk through logistic regression models; multivariable and centre adjustment, propensity score analyses, and E-values were calculated to limit confounding.827 nonintubated patients with COVID-19 in the awake prone (n=505) and awake supine (n=322) groups were included for analysis. Fewer patients in the awake prone group required endotracheal intubation (23.6% versus 40.4%) or died (19.8% versus 37.3%). Awake prone positioning was a protective factor for intubation even after multivariable adjustment (OR 0.35, 95% CI 0.24-0.52; p<0.0001, E=2.12), which prevailed after propensity score analysis (OR 0.41, 95% CI 0.27-0.62; p<0.0001, E=1.86) and mortality (adjusted OR 0.38, 95% CI 0.26-0.55; p<0.0001, E=2.03). The main variables associated with intubation among awake prone patients were increasing age, lower baseline peripheral arterial oxygen saturation/inspiratory oxygen fraction ratio (PaO2 /FIO2 ) and management with a nonrebreather mask.Awake prone positioning in hospitalised nonintubated patients with COVID-19 is associated with a lower risk of intubation and mortality.
Statins act as transient type I interferon inhibitors to enable the antitumor activity of modified vaccinia Ankara viral vectors
Authors: Shirley Tenesaca, Marcos Vasquez, Maite Alvarez, Itziar Otano, Myriam Fernandez-Sendin, Claudia Augusta Di Trani, Nuria Ardaiz, Celia Gomar, Angela Bella, Fernando Aranda, José Medina-Echeverz, Ignacio Melero, Pedro Berraondo
Journal: Journal for ImmunoTherapy of Cancer (2021)

Background Modified vaccinia virus Ankara (MVA) are genetically engineered non-replicating viral vectors. Intratumoral administration of MVA induces a cyclic GMP-AMP synthase-mediated type I interferon (IFN) response and the production of high levels of the transgenes engineered into the viral genome such as tumor antigens to construct cancer vaccines. Although type I IFNs are essential for establishing CD8-mediated antitumor responses, this cytokine family may also give rise to immunosuppressive mechanisms. Methods In vitro assays were performed to evaluate the activity of simvastatin and atorvastatin on type I IFN signaling and on antigen presentation. Surface levels of IFN α/β receptor 1, endocytosis of bovine serum albumin-fluorescein 5 (6)-isothiocyanate, signal transducer and activator of transcription (STAT) phosphorylation, and real-time PCR of IFN-stimulated genes were assessed in the murine fibroblast cell line L929. In vivo experiments were performed to characterize the effect of simvastatin on the MVA-induced innate immune response and on the antitumor effect of MVA-based antitumor vaccines in B16 melanoma expressing ovalbumin (OVA) and Lewis lung carcinoma (LLC)-OVA tumor models. RNAseq analysis, depleting monoclonal antibodies, and flow cytometry were used to evaluate the MVA-mediated immune response. Results In this work, we identified commonly prescribed statins as potent IFNα pharmacological inhibitors due to their ability to reduce surface expression levels of IFN-α/β receptor 1 and to reduce clathrin-mediated endocytosis. Simvastatin and atorvastatin efficiently abrogated for 8 hours the transcriptomic response to IFNα and enhanced the number of dendritic cells presenting an OVA-derived peptide bound to major histocompatibility complex (MHC) class I. In vivo, intraperitoneal or intramuscular administration of simvastatin reduced the inflammatory response mediated by peritumoral administration of MVA and enhanced the antitumor activity of MVA encoding tumor-associated antigens. The synergistic antitumor effects critically depend on CD8 + cells, whereas they were markedly improved by depletion of CD4 + lymphocytes, T regulatory cells, or NK cells. Either MVA-OVA alone or combined with simvastatin augmented B cells, CD4 + lymphocytes, CD8 + lymphocytes, and tumor-specific CD8 + in the tumor-draining lymph nodes. However, only the treatment combination increased the numbers of these lymphocyte populations in the tumor microenvironment and in the spleen. Conclusion In conclusion, blockade of IFNα functions by simvastatin markedly enhances lymphocyte infiltration and the antitumor activity of MVA, prompting a feasible drug repurposing.
Personalized Postprandial Glucose Response–Targeting Diet Versus Mediterranean Diet for Glycemic Control in Prediabetes
Authors: Orly Ben-Yacov, Anastasia Godneva, Michal Rein, Smadar Shilo, Dmitry Kolobkov, Netta Koren, Noa Cohen Dolev, Tamara Travinsky Shmul, Bat Chen Wolf, Noa Kosower, Keren Sagiv, Maya Lotan-Pompan, Niv Zmora, Adina Weinberger, Eran Elinav, Eran Segal
Journal: Diabetes Care (2021)

OBJECTIVE To compare the clinical effects of a personalized postprandial-targeting (PPT) diet versus a Mediterranean (MED) diet on glycemic control and metabolic health in prediabetes. RESEARCH DESIGN AND METHODS We randomly assigned adults with prediabetes (n = 225) to follow a MED diet or a PPT diet for a 6-month dietary intervention and additional 6-month follow-up. The PPT diet relies on a machine learning algorithm that integrates clinical and microbiome features to predict personal postprandial glucose responses. During the intervention, all participants were connected to continuous glucose monitoring (CGM) and self-reported dietary intake using a smartphone application. RESULTS Among 225 participants randomized (58.7% women, mean ± SD age 50 ± 7 years, BMI 31.3 ± 5.8 kg/m2, HbA1c, 5.9 ± 0.2% [41 ± 2.4 mmol/mol], fasting plasma glucose 114 ± 12 mg/dL [6.33 ± 0.67 mmol/L]), 200 (89%) completed the 6-month intervention. A total of 177 participants also contributed 12-month follow-up data. Both interventions reduced the daily time with glucose levels &amp;gt;140 mg/dL (7.8 mmol/L) and HbA1c levels, but reductions were significantly greater in PPT compared with MED. The mean 6-month change in “time above 140” was −0.3 ± 0.8 h/day and −1.3 ± 1.5 h/day for MED and PPT, respectively (95% CI between-group difference −1.29 to −0.66, P &amp;lt; 0.001). The mean 6-month change in HbA1c was −0.08 ± 0.19% (−0.9 ± 2.1 mmol/mol) and −0.16 ± 0.24% (−1.7 ± 2.6 mmol/mol) for MED and PPT, respectively (95% CI between-group difference −0.14 to −0.02, P = 0.007). The significant between-group differences were maintained at 12-month follow-up. No significant differences were noted between the groups in a CGM-measured oral glucose tolerance test. CONCLUSIONS In this clinical trial in prediabetes, a PPT diet improved glycemic control significantly more than a MED diet as measured by daily time of glucose levels &amp;gt;140 mg/dL (7.8 mmol/L) and HbA1c. These findings may have implications for dietary advice in clinical practice.
Involvement of Macrophages in Induction of Apoptosis of Human Erythroid Progenitor Cells
Authors: Y. Suehiro, K. Muta, M. Nakashima, Y. Abe, M. Shiratsuchi, S. Shiokawa, S. Ikuyama, Y. Yoshikawa, T. Watanabe, J. Nishimura
Journal: Blood (2002)
Development of patient-centred standards of care for rheumatoid arthritis in Europe: the eumusc.net project
Authors: Michaela A Stoffer, Josef S Smolen, Anthony Woolf, Ales Ambrozic, Ailsa Bosworth, Loreto Carmona, Veronika Fialka-Moser, Estibaliz Loza, Pawel Olejnik, Ingemar F Petersson, Till Uhlig, Tanja A Stamm
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objective</h3> The eumusc.net project is a European Union (EU) commission and European League Against Rheumatism (EULAR)funded project that aims to facilitate equal standards for musculoskeletal health in all EU countries. One work-package was to develop evidence-based and patient-centred standards of care (SOC), for rheumatoid arthritis (RA) understandable for patients and professionals across Europe. <h3>Method</h3> A review of documents covering clinical practice 'guidelines' and SOC for RA was conducted. The obtained documents were evaluated using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) criteria, and all recommended methods to treat RA were extracted. Based on this information, a three-round Delphi exercise was performed including a consensus group meeting of 21 researchers and patient representatives. <h3>Results</h3> 16 patient-centred SOC were formulated including a lay version in the format of a checklist. An example is SOC 3: 'People with RA should receive a treatment plan developed individually between them and their clinician at each visit.' The corresponding checklist question reads: 'Have I received a treatment plan which includes an explanation of my management, expected goals and outcomes and important contact details?' <h3>Conclusions</h3> The SOC for RA will be available in all 23 official European languages and contribute to more unified treatment approaches in Europe.
Silicified collagen scaffold induces semaphorin 3A secretion by sensory nerves to improve in-situ bone regeneration
Authors: Yu-Xuan Ma, Kai Jiao, Qian-Qian Wan, Jing Li, Ming-Yi Liu, Zi-Bin Zhang, Wen Qin, Kai-Yan Wang, Ya-zhou Wang, Franklin R. Tay, Li-Na Niu
Journal: Bioactive Materials (2021)

Sensory nerves promote osteogenesis through the release of neuropeptides. However, the potential application and mechanism in which sensory nerves promote healing of bone defects in the presence of biomaterials remain elusive. The present study identified that new bone formation was more abundantly produced after implantation of silicified collagen scaffolds into defects created in the distal femur of rats. The wound sites were accompanied by extensive nerve innervation and angiogenesis. Sensory nerve dysfunction by capsaicin injection resulted in significant inhibition of silicon-induced osteogenesis in the aforementioned rodent model. Application of extracellular silicon in vitro induced axon outgrowth and increased expression of semaphorin 3 A (Sema3A) and semaphorin 4D (Sema4D) in the dorsal root ganglion (DRG), as detected by the upregulation of signaling molecules. Culture medium derived from silicon-stimulated DRG cells promoted proliferation and differentiation of bone marrow mesenchymal stem cells and endothelial progenitor cells. These effects were inhibited by the use of Sema3A neutralizing antibodies but not by Sema4D neutralizing antibodies. Knockdown of Sema3A in DRG blocked silicon-induced osteogenesis and angiogenesis almost completely in a femoral defect rat model, whereas overexpression of Sema3A promoted the silicon-induced phenomena. Activation of "mechanistic target of rapamycin" (mTOR) pathway and increase of Sema3A production were identified in the DRG of rats that were implanted with silicified collagen scaffolds. These findings support the role of silicon in inducing Sema3A production by sensory nerves, which, in turn, stimulates osteogenesis and angiogenesis. Taken together, silicon has therapeutic potential in orthopedic rehabilitation.
Exosome-derived noncoding RNAs in gastric cancer: functions and clinical applications
Authors: Xiao-Huan Tang, Ting Guo, Xiang-Yu Gao, Xiao-Long Wu, Xiao-Fang Xing, Jia-Fu Ji, Zi-Yu Li
Journal: Molecular Cancer (2021)

Exosomes are a subpopulation of the tumour microenvironment (TME) that transmit various biological molecules to promote intercellular communication. Exosomes are derived from nearly all types of cells and exist in all body fluids. Noncoding RNAs (ncRNAs) are among the most abundant contents in exosomes, and some ncRNAs with biological functions are specifically packaged into exosomes. Recent studies have revealed that exosome-derived ncRNAs play crucial roles in the tumorigenesis, progression and drug resistance of gastric cancer (GC). In addition, regulating the expression levels of exosomal ncRNAs can promote or suppress GC progression. Moreover, the membrane structures of exosomes protect ncRNAs from degradation by enzymes and other chemical substances, significantly increasing the stability of exosomal ncRNAs. Specific hallmarks within exosomes that can be used for exosome identification, and specific contents can be used to determine their origin. Therefore, exosomal ncRNAs are suitable for use as diagnostic and prognostic biomarkers or therapeutic targets. Regulating the biogenesis of exosomes and the expression levels of exosomal ncRNAs may represent a new way to block or eradicate GC. In this review, we summarized the origins and characteristics of exosomes and analysed the association between exosomal ncRNAs and GC development.
O17-1 Subcutaneous (SC) epcoritamab induces complete responses across R/R B-cell NHL subtypes: Updated dose-escalation data
Authors: Martin Hutchings, Rogier Mous, Michael Roost Clausen, Peter Johnson, Kim M. Linton, Martine E.D. Chamuleau, David J. Lewis, Anna Sureda Balari, David Cunningham, Roberto S. Oliveri, Dena DeMarco, Brian Elliott, Kuo-mei Chen, Pieternella J. Lugtenburg
Journal: Annals of Oncology (2021)
Adoptive Immunotherapy with Rapidly-Generated Multivirus-Specific T Cells Against AdV, EBV, CMV, HHV6 and BK after Allogeneic Hematopoietic Stem Cell Transplant
Authors: Ifigeneia Tzannou, Anastasia Papadopoulou, Ayumi Watanabe, Manik Kuvalekar, Adrian P. Gee, Swati Naik, Caridad A. Martinez, Kathryn Leung, Ghadir Sasa, Premal Lulla, Robert A. Krance, George Carrum, Carlos A. Ramos, Juan F. Vera, Bambi J. Grilley, Malcolm K. Brenner, Cliona M. Rooney, Helen E. Heslop, Ann M. Leen, Bilal Omer
Journal: Blood (2017)
P50-4 Neurogenic shock caused by CNS relapse of DLBCL
Authors: Masaki Maruta, Kazuto Takeuchi, Kensuke Senzaki, Siro Miura, Jun-ichi Kato, Shogo Nabe, Yuichi Ikeda, Toshiki Ochi, Takashi Haro, Kazushi Tanimoto, Jun Yamanouchi, Yoshihiro Yakushijin, Katsuto Takenaka
Journal: Annals of Oncology (2021)
O10-3 Selpercatinib (LOXO-292) in patients (pts) with RET-altered thyroid cancer
Authors: Lori J. Wirth, Eric J. Sherman, Bruce Robinson, Benjamin Solomon, Hyunseok Kang, Jochen H. Lorch, Francis Worden, Marcia S. Brose, Sophie Leboulleux, Yann Godbert, Marie Meurer, John Morris, Taofeek K. Owonikoko, Daniel Shao-Weng Tan, Oliver Gautschi, Jyoti Patel, Luxi Yang, Jennifer Kherani, Maria E. Cabanillas, Manisha H. Shah
Journal: Annals of Oncology (2021)
An ACE inhibitor reduces bactericidal activity of human neutrophils in vitro and impairs mouse neutrophil activity in vivo
Authors: Duo-Yao Cao, Jorge F. Giani, Luciana C. Veiras, Ellen A. Bernstein, Derick Okwan-Duodu, Faizan Ahmed, Catherine Bresee, Warren G. Tourtellotte, S. Ananth Karumanchi, Kenneth E. Bernstein, Zakir Khan
Journal: Science Translational Medicine (2021)

Angiotensin-converting enzyme inhibitors (ACEIs) are used by millions of patients to treat hypertension, diabetic kidney disease, and heart failure. However, these patients are often at increased risk of infection. To evaluate the impact of ACEIs on immune responses to infection, we compared the effect of an ACEI versus an angiotensin receptor blocker (ARB) on neutrophil antibacterial activity. ACEI exposure reduced the ability of murine neutrophils to kill methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, and Klebsiella pneumoniae in vitro. In vivo, ACEI-treated mice infected with MRSA had increased bacteremia and tissue bacteria counts compared to mice treated with an ARB or with no drug. Similarly, ACEIs, but not ARBs, increased the incidence of MRSA-induced infective endocarditis in mice with aortic valve injury. Neutrophils from ACE knockout (KO) mice or mice treated with an ACEI produced less leukotriene B4 (LTB4) upon stimulation with MRSA or lipopolysaccharide, whereas neutrophils overexpressing ACE produced more LTB4 compared to wild-type neutrophils. As a result of reduced LTB4 production, ACE KO neutrophils showed decreased survival signaling and increased apoptosis. In contrast, neutrophils overexpressing ACE had an enhanced survival phenotype. Last, in a cohort of human volunteers receiving the ACEI ramipril for 1 week, ACEI administration reduced neutrophil superoxide and reactive oxygen species production and neutrophils isolated from volunteers during ramipril treatment had reduced bactericidal activity. Together, these data demonstrate that ACEI treatment, but not ARB treatment, can reduce the bacterial killing ability of neutrophils.
Diagnostic Accuracy of Stress Perfusion CMR for Risk Stratification in Patients With MR-Conditional Pacemakers
Authors: Théo Pezel, Jérôme Lacotte, Solenn Toupin, Fiorella Salerno, Mina Ait Said, Vladimir Manenti, Laurent Fiorina, Philippe Garot, Thomas Hovasse, Thierry Unterseeh, Francesca Sanguineti, Jérôme Horvilleur, Jérôme Garot
Journal: JACC. Cardiovascular imaging (2021)
Effectiveness of typhoid conjugate vaccine against culture-confirmed Salmonella enterica serotype Typhi in an extensively drug-resistant outbreak setting of Hyderabad, Pakistan: a cohort study
Authors: Mohammad Tahir Yousafzai, Sultan Karim, Sonia Qureshi, Momin Kazi, Hina Memon, Amber Junejo, Zohra Khawaja, Najeeb Ur Rehman, Muhammad Sajid Ansari, Rafey Ali, Ikram Uddin Ujjan, Heera Mani Lohana, Naveed M Memon, Mudassar Hussain, Roohi Nigar, Naor Bar-Zeev, Farah Naz Qamar
Journal: The Lancet Global Health (2021)

Salmonella enterica serotype Typhi (S Typhi) is a major public health problem in low-income and middle-income countries. We aimed to investigate the effectiveness and impact of the typhoid conjugate vaccine Typbar-TCV against S Typhi among children in an outbreak setting of extensively drug-resistant (XDR) S Typhi in Pakistan.This cohort study was done from Feb 21, 2018, to Dec 31, 2019. A census survey of all households located in the Qasimabad and Latifabad subdistricts of Hyderabad, Pakistan, was done at baseline, and 174 005 households were registered in the census. The Typbar-TCV immunisation campaign was initiated at temporary vaccination centres and 207 000 children aged 6 months to 10 years were vaccinated from Feb 21, 2018, to Dec 31, 2018. Social mobilisers informed parents about the vaccination process. Vaccination records were maintained electronically and linked with the household census surveys. Active surveillance for suspected and blood-culture-confirmed S Typhi was established in hospitals, clinics, and laboratories to assess the following outcomes: cases of suspected typhoid fever, culture-confirmed S Typhi, and antimicrobial resistance. An age-stratified cohort of 1100 vaccinated children was randomly selected from the vaccination registry, tested for Vi-IgG antibodies (data not reported), and followed up fortnightly (via telephone calls or household visits) until Dec 31, 2019, for ascertainment of outcomes during the study period. 20 847 vaccinated and unvaccinated children were randomly selected from the census registry as a quality control cohort and followed up from Oct 1 to Dec 31, 2019, for ascertainment of outcomes. Vaccine effectiveness against suspected, culture-confirmed, and XDR S Typhi was calculated.23 407 children from the census registry and surveillance system were included in the vaccine effectiveness analysis. 13 436 (57·4%) children were vaccinated, 12 214 (52·2%) were male, and 10 168 (43·4%) were aged 6-59 months. 5378 (23·0%) of 23 407 children had suspected S Typhi, among whom 775 (14·4%) had culture-confirmed S Typhi and 361 (68·6%) of 526 had XDR S Typhi. Vaccine effectiveness was 55% (95% CI 52-57) against suspected S Typhi (regardless of culture confirmation), 95% (93-96) against culture-confirmed S Typhi, and 97% (95-98) against XDR S Typhi.Typbar-TCV is effective in protecting children against S Typhi infection in an outbreak setting, and was able, with moderate deployment, to curtail a major XDR S Typhi outbreak in a densely populated setting. The vaccine shows efficacy against S Typhi irrespective of antimicrobial resistance.Bill & Melinda Gates Foundation.
Expression Profiling of Micro RNAs (MiRNAs) and Long Non-Coding RNAs (lncRNAs) in Chronic Myeloid Leukemia (CML) Patients in the State of Qatar
Authors: Nader I. Al-Dewik, Salsabel Elshami, Nada Nasser, Mohammed Alsharshani, Mohammed Araby, Mohamed A. Yassin, Pejman H. Moghaddam
Journal: Blood (2017)
The Action‐Networks of Nanosilver: Bridging the Gap between Material and Biology
Authors: Huiliang Cao, Hui Qin, Yongsheng Li, Klaus D. Jandt
Journal: Advanced Healthcare Materials (2021)

The emergence of nanosilver (silver in nanoscale shapes and their assemblies) benefits the landscape of modern healthcare; however, this brings about concerns over its safety issues associated with an ultrasmall size and high mobility. By reviewing previous reporting details about the synthesis and characterization of nanosilver and its biological responses, a gap between materials synthesis and their biomedical uses is characterized by the insufficient understanding of the interacting and interplaying nanoscale actions of silver. To improve reporting quality and advance clinical translations, it is suggested that researchers have a comprehensive recognition of the "Indications for use" before designing innovative nanosilver-based materials and an "Action-network" concept addressing the acting range and strength of those nanoscale actions is implemented. Although this discussion is specific to nanosilver, the idea of "Indications for use" centered design and synthesis is generally applicable to other biomedical nanomaterials.
A recombinant spike protein subunit vaccine confers protective immunity against SARS-CoV-2 infection and transmission in hamsters
Authors: Yangtao Wu, Xiaofen Huang, Lunzhi Yuan, Shaojuan Wang, Yali Zhang, Hualong Xiong, Rirong Chen, Jian Ma, Ruoyao Qi, Meifeng Nie, Jingjing Xu, Zhigang Zhang, Liqiang Chen, Min Wei, Ming Zhou, Minping Cai, Yang Shi, Liang Zhang, Huan Yu, Junping Hong, Zikang Wang, Yunda Hong, Mingxi Yue, Zonglin Li, Dabing Chen, Qingbing Zheng, Shaowei Li, Yixin Chen, Tong Cheng, Jun Zhang, Tianying Zhang, Huachen Zhu, Qinjian Zhao, Quan Yuan, Yi Guan, Ningshao Xia
Journal: Science Translational Medicine (2021)

A SARS-CoV-2 spike protein subunit vaccine induced humoral and cellular immune responses that protected hamsters against infection and prevented transmission.