tbuckley/cabot-search huggingface dataset:
Abstract 14694: Klotho Attenuates Hyperglycemia-Induced Cardiac Hypertrophy and Dysfunction by Concomitantly Activating Nrf2 and Brg1
Authors: Yue Guo, Jing Zou, Lingling Wu, Xiaodong Zhuang, Xinxue Liao
Journal: Circulation (2019)

Introduction: Cardiac oxidative stress play a key role in the pathogenesis of diabetic cardiomyopathy (DCM), that is associated with reduced anti-aging protein Klotho and heme oxygenase-1 (HO-1). B...
MO01.23 Canakinumab or Pembrolizumab as Monotherapy or in Combination as Neoadjuvant Therapy in Patients with Surgically Resected Non-Small Cell Lung Cancer (NSCLC): CANOPY-N Trial
Authors: J. Lee, P. Garrido, E. Kim, C. Arslan, J.L. Pujol, M. Tsuboi, T. Dong, C. Blin, V. Rodrik-Outmezguine, B. Mookerjee, V. Passos, T. Mok
Journal: Journal of Thoracic Oncology (2021)
The Risk of Anal Carcinoma After Anogenital Warts in Adults Living With HIV
Authors: Justin D. Arnold, Morgan E. Byrne, Anne K. Monroe, Stephen E. Abbott
Journal: JAMA Dermatology (2021)

<h3>Importance</h3> In the US, incidence of and mortality due to anal carcinoma are rising faster than for most other cancers. Identifying populations who have a higher risk of developing anal cancers is critical to target preventive interventions. <h3>Objective</h3> To assess the risk of developing anal carcinoma in adults living with HIV who have a history of anogenital warts. <h3>Design, Setting, and Participants</h3> This longitudinal cohort study included adults living with HIV from 14 clinics in Washington, DC, and at least 18 months of follow-up. Data were collected from January 1, 2011, to March 31, 2017, and analyzed from June 1, 2019, to October 31, 2020. <h3>Exposures</h3> Development of warts in the anal or genital region identified by diagnosis codes. <h3>Main Outcomes and Measures</h3> Individuals with anal carcinoma were identified by diagnosis codes or anal biopsy results. <h3>Results</h3> A total of 6515 participants were enrolled (4720 male [72.4%] at birth; mean [SD] age, 49.9 [12.7] years), and 383 (5.9%) developed anogenital warts during the study period. Patients who were diagnosed with anogenital warts were more likely to subsequently develop anal carcinoma (17 of 383 [4.4%]) compared with participants without a history of anogenital warts (17 of 6132 [0.3%]) (<i>P</i> &lt; .001). After adjusting for covariates, the odds of developing anal carcinoma were 12.79 (95% CI, 6.19-26.45;<i>P</i> &lt; .001) times higher in individuals with a history of anogenital warts compared with individuals without a history of anogenital warts. <h3>Conclusions and Relevance</h3> These findings suggest that adults living with HIV who have a history of anogenital warts have a substantially increased risk of developing anal carcinoma. Clinicians should counsel individuals living with HIV who have anogenital warts on this risk.
Hypertrophic Cardiomyopathy: Refining the Lens of Cardiac Magnetic Resonance to Evaluate Late Gadolinium Enhancement⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Authors: David A. Bluemke, Eunice Yang
Journal: Journal of the American College of Cardiology (2012)
Temporal trends in mortality and readmission after acute heart failure: a systematic review and meta‐regression in the past four decades
Authors: Antoine Kimmoun, Koji Takagi, Emmanuel Gall, Shiro Ishihara, Pierre Hammoum, Nathan El Bèze, Alexandre Bourgeois, Guillaume Chassard, Hugo Pegorer‐Sfes, Etienne Gayat, Alain C. Solal, Alexa Hollinger, Thomas Merkling, Alexandre Mebazaa
Journal: European Journal of Heart Failure (2021)
Alterations of DNA damage response pathway: Biomarker and therapeutic strategy for cancer immunotherapy
Authors: Minlin Jiang, Keyi Jia, Lei Wang, Wei Li, Bin Chen, Yu Liu, Hao Wang, Sha Zhao, Yayi He, Caicun Zhou
Journal: Acta Pharmaceutica Sinica B (2021)

Genomic instability remains an enabling feature of cancer and promotes malignant transformation. Alterations of DNA damage response (DDR) pathways allow genomic instability, generate neoantigens, upregulate the expression of programmed death ligand 1 (PD-L1) and interact with signaling such as cyclic GMP–AMP synthase-stimulator of interferon genes (cGAS–STING) signaling. Here, we review the basic knowledge of DDR pathways, mechanisms of genomic instability induced by DDR alterations, impacts of DDR alterations on immune system, and the potential applications of DDR alterations as biomarkers and therapeutic targets in cancer immunotherapy.
STaRT-RWE: structured template for planning and reporting on the implementation of real world evidence studies
Authors: Shirley V Wang, Simone Pinheiro, Wei Hua, Peter Arlett, Yoshiaki Uyama, Jesse A Berlin, Dorothee B Bartels, Kristijan H Kahler, Lily G Bessette, Sebastian Schneeweiss
Journal: BMJ (2021)

Previous research has provided evidence that in the last decade, investing according to screening based on environmental, social, and governance (ESG) criteria would have allowed investors to considerably improve the ESG quality of their portfolio without deterioration of its financial performance. However, a drawback of such a screening process is that it may generate undesirable regional, sectoral, and risk factor exposures. In this article, the authors propose an investment strategy that maximizes the ESG quality of the portfolio while maintaining regional, sectoral, and risk factor exposures within stated limits. They provide evidence that such a portfolio would have produced risk-adjusted performance at least as high as the standard MSCI benchmark for a wide range of ESG criteria and regions over the 2007–2018 investment period. <b>TOPICS:</b>ESG investing, analysis of individual factors/risk premia, risk management, performance measurement <b>Key Findings</b> ▪ The authors show that improving the environmental, social, and governance (ESG) score of a portfolio through screening can generate undesirable regional, sectoral, and risk factor exposures. ▪ They describe an investment strategy that maximizes the ESG quality of the portfolio while maintaining regional, sectoral, and risk factor exposures within stated limits. ▪ Such a strategy would have produced a risk-adjusted performance at least as high as the standard benchmark for a wide range of ESG criteria and regions over the 2007–2018 investment period.
Encapsulated Mesenchymal Stromal Cell Microbeads Promote Endogenous Regeneration of Osteoarthritic Cartilage Ex Vivo
Authors: Neety Sahu, Pranay Agarwal, Fiorella Grandi, Michela Bruschi, Stuart Goodman, Derek Amanatullah, Nidhi Bhutani
Journal: Advanced Healthcare Materials (2021)

The anti-inflammatory secretome of mesenchymal stromal cells (MSCs) is lucrative for the treatment of osteoarthritis (OA), a disease characterized by low-grade inflammation. However, the precise effects of the MSC secretome on patient-derived OA tissue is lacking. To investigate these effects, alginate encapsulated MSCs are co-cultured with patient-derived OA cartilage explants for 8 days. Proteoglycan distribution in OA cartilage explants examined by Safranin O staining is markedly improved when cultured with MSC microbeads as compared to control OA explants cultured alone. Total sulfated glycosaminoglycan (sGAG) content in OA explants is significantly increased upon co-culture with MSC microbeads on day 8. The sGAG released into the culture media is unchanged by the presence of MSC microbeads, suggesting de novo sGAG synthesis in OA explants. Co-culture with MSC microbeads increased the DNA content and Ki67+ cells in OA explants, indicating proliferation. An increase in secreted cytokines IL-10, HGF, and sFAS assessed by multiplex cytokine assay, increased TIMP1 levels, and reduction in percent apoptotic cells in OA explants is noted. Together, data demonstrates that paracrine factors secreted by alginate encapsulated MSCs microbeads in response to OA cartilage, create an anabolic, proliferative, and anti-apoptotic microenvironment inducing endogenous regeneration in clinically relevant, patient-derived OA cartilage.
Soluble CX3CL1/Fractalkine Is a New Player in the Pro-Inflammatory Microenvironment of Multiple Myeloma Patients Related to Bone Marrow Plasma Cell Infiltration and Neo-Vascularization
Authors: Anna Corcione, Valentina Marchica, Elisa Ferretti, Denise Toscani, Marina Bolzoni, Federica Costa, Cristina Mancini, Eugenia Martella, Fabrizio Accardi, Laura Notarfranchi, Domenico Ribatti, Angelo Vacca, Franco Aversa, Vito Pistoia, Nicola Giuliani
Journal: Blood (2017)
Abstract 14752: Hepatic Steatosis in Patients With the Fontan Circulation
Authors: David Katz, Daniel Peck, Adam Lubert, Mathias Possner, Faizeen Zafar, Andrew Trout, Joseph Palermo, Nadeem Anwar, Jonathan Dillman, Adam Powell, Starva Xanthakos, Alexander Opotowsky, Gruschen Veldtman, Tarek Alsaied
Journal: Circulation (2020)

Introduction: Hepatic steatosis is a leading cause of chronic liver disease, and it is most commonly attributed to nonalcoholic fatty liver disease (NAFLD). The interplay between hepatic steatosis and the development of liver disease following the Fontan procedure is not well understood. This study examined the prevalence and associations of hepatic steatosis in patients with a Fontan circulation. Methods and Results: This was a single-center retrospective study of 95 patients with a Fontan circulation who had a liver magnetic resonance imaging (MRI) performed between 2012 and 2019. Average age at MRI was 21.5 ± 8.5 years. Percent liver fat signal was determined using magnetic resonance chemical shift-encoded proton density fat fraction imaging. Hepatic steatosis was defined as liver fat greater than or equal to 5%; this was present in 10.5% of the population. The presence of hepatic steatosis was associated with higher body mass index (BMI) (29 ± 4 vs. 24 ± 6 kg/m 2 , p = 0.01), a higher frequency of obesity (50 vs. 12%, p = 0.02), lower high density lipoprotein (HDL) cholesterol (35 ± 9 vs. 43 ± 14 mg/dL, p = 0.05), and greater subcutaneous fat (2.6 ± 0.7 vs. 1.8 ± 1.0 cm, p = 0.04). Percent liver fat was positively associated with AST, triglyceride, and alkaline phosphatase levels. There was no association between hepatic steatosis and cardiovascular imaging or hemodynamic variables. Hepatic steatosis was not associated with the development of the composite outcome of: death, heart transplant, or escalation of diuretics (10 vs. 25%, p = 0.44). Conclusions: Risk factors for hepatic steatosis in patients with Fontan circulation are similar to the general population: obesity and dyslipidemia.
MO01.32 CodeBreaK 200: A Phase 3 Multicenter Study of Sotorasib, a KRAS(G12C) Inhibitor, versus Docetaxel in Patients with Previously Treated Advanced Non-Small Cell Lung Cancer (NSCLC) Harboring KRAS p.G12C Mutation
Authors: M. Reck, A. Spira, B. Besse, J. Wolf, F. Skoulidis, H. Borghaei, K. Goto, K. Park, F. Griesinger, E.F. Font, M. Boyer, C.H. Barrios, G. Goss, H. Yang, C. Obiozor, S. Ramalingam
Journal: Journal of Thoracic Oncology (2021)
Hereditary Diffuse Gastric Cancer Syndrome and the Role of <i>CDH1</i>
Authors: Lauren A. Gamble, Theo Heller, Jeremy L. Davis
Journal: JAMA Surgery (2021)

<h3>Importance</h3> Inherited variants in the tumor suppressor gene<i>CDH1</i>are associated with an increased risk of gastric and breast cancers. This review aims to address the most current topics in management of the hereditary diffuse gastric cancer syndrome attributed to<i>CDH1</i>. <h3>Observations</h3> Consensus management guidelines have broadened genetic testing criteria for<i>CDH1</i>. Prophylactic total gastrectomy is recommended for any pathogenic or likely pathogenic<i>CDH1</i>variant carrier starting at the age of 20 years. Annual surveillance endoscopy is recommended to those who defer prophylactic total gastrectomy. Women with a<i>CDH1</i>variant should initiate magnetic resonance imaging breast surveillance starting at age 30 years. Further research is needed to understand the pathogenesis of early-stage gastric cancers (T1a), which are pathognomonic of hereditary diffuse gastric cancer syndrome, that lead to advanced gastric cancer to develop both treatment and prevention strategies for this patient population. <h3>Conclusions and Relevance</h3> The heritable<i>CDH1</i>gene mutation is of importance to today’s surgeons because it is associated with a substantial increased risk of developing both gastric and breast cancers. Management of this cancer syndrome currently uses prophylactic surgery and enhanced cancer surveillance strategies.
Highly specific and label-free histological identification of microcrystals in fresh human gout tissues with stimulated Raman scattering
Authors: Bohan Zhang, Hanlin Xu, Jun Chen, Xiaoxia Zhu, Yu Xue, Yifan Yang, Jianpeng Ao, Yinghui Hua, Minbiao Ji
Journal: Theranostics (2021)

Gout is a common metabolic disease with growing burden, caused by monosodium urate (MSU) microcrystal deposition. In situ and chemical-specific histological identification of MSU is crucial in the diagnosis and management of gout, yet it remains inaccessible for current histological methods. Methods: Stimulated Raman scattering (SRS) microscopy was utilized to image MSU based on its fingerprint Raman spectra. We first tested SRS for the diagnosis capability of gout and the differentiation power from pseudogout with rat models of acute gout arthritis, calcium pyrophosphate deposition disease (CPDD) and comorbidity. Then, human synovial fluid and surgical specimens (n=120) were were imaged with SRS to obtain the histopathology of MSU and collagen fibers. Finally, quantitative SRS analysis was performed in gout tissue of different physiological phases (n=120) to correlate with traditional histopathology including H&E and immunohistochemistry staining. Results: We demonstrated that SRS is capable of early diagnosis of gout, rapid detection of MSU in synovial fluid and fresh unprocessed surgical tissues, and accurate differentiation of gout from pseudogout in various pathophysiological conditions. Furthermore, quantitative SRS analysis revealed the optical characteristics of MSU deposition at different pathophysiological stages, which were found to matched well with corresponding immunofluorescence histochemistry features. Conclusion: Our work demonstrated the potential of SRS microscopy for rapid intraoperative diagnosis of gout and may facilitate future fundamental researches of MSU-based diseases.
<i>QuickStats:</i> Prevalence of Complete Tooth Loss* Among Adults Aged ≥65 Years,† by Federal Poverty Level§ — National Health and Nutrition Examination Survey, United States, 1999–2018
Authors: Eleanor Fleming, Joseph Afful, Deanna Kruszon
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

Defined as the loss of all natural, permanent teeth.† Estimates for the category of persons aged ≥65 years were age-adjusted by the direct method to the year 2000 U.S. Census population using the age groups 65-69, 70-74, and ≥75 years.§ Poverty index category was calculated by dividing family income by a poverty threshold specific for family size using the U.S. Department of Health and Human Services poverty guidelines.https://aspe.hhs.gov/poverty-guidelines.The age-adjusted prevalence of complete tooth loss among adults aged ≥65 years decreased from 29.3% during 1999-2000 to 12.6% during 2017-2018.For the same period, the prevalence decreased from 42.1% to 23.5% for adults living at <200% of the federal poverty level and from 17.7% to 8.5% for adults living at ≥200% of the federal poverty level.Throughout the period, the prevalence of complete tooth loss was higher among those living at <200% of the federal poverty level.
Long-term Complications of Bariatric Surgery
Authors: Daniel Weiss
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Temporal Trends in Incident Hospitalization for Diabetes-Related Foot Ulcer in Type 2 Diabetes: The Fremantle Diabetes Study
Authors: Emma J. Hamilton, Wendy A. Davis, Ranita Siru, Mendel Baba, Paul E. Norman, Timothy M.E. Davis
Journal: Diabetes Care (2021)

OBJECTIVE To determine whether, reflecting trends in other chronic complications, incident hospitalization for diabetes-related foot ulcer (DFU) has declined over recent decades in type 2 diabetes. RESEARCH DESIGN AND METHODS Participants with type 2 diabetes from the community-based Fremantle Diabetes Study phases I (FDS1; 1,296 participants, mean age 64.0 years, 48.6% males, recruited 1993–1996) and II (FDS2; 1,509 participants, mean age 65.4 years, 51.8% males, recruited 2008–2011) were followed from entry to first hospitalization for/with DFU, death, or 5 years (whichever came first). Incident rate ratios (IRRs) and incident rate differences (IRDs) were calculated for FDS2 versus FDS1 overall and in 10-year age-groups. Cox proportional hazards modeling determined independent predictors of first DFU hospitalization in the combined cohort. RESULTS Incident DFU hospitalization (95% CI) was 1.9 (0.9–3.3)/1,000 person-years in FDS1 during 5,879 person-years of follow-up and 4.5 (3.0–6.4)/1,000 person-years in FDS2 during 6,915 person-years of follow-up. The crude IRR (95% CI) was 2.40 (1.17–5.28) (P = 0.013) and IRD 2.6 (0.7–4.5)/1,000 person-years (P = 0.010). The highest IR for any age-group was 23.6/1,000 person-years in FDS2 participants aged 31–40 years. Age at diabetes diagnosis (inverse), HbA1c, insulin use, height, ln(urinary albumin/creatinine), absence of any foot pulse, previous peripheral revascularization, and peripheral sensory neuropathy (PSN) were independent predictors of incident hospitalization for/with DFU. CONCLUSIONS Incident DFU hospitalizations complicating type 2 diabetes increased between FDS phases, especially in younger participants, and were more likely in those with PSN, peripheral arterial disease, and suboptimal glycemic control at baseline.
Mucocutaneous Adverse Events Associated With Oral Sirolimus for the Treatment of Vascular Anomalies
Authors: Pierre-Olivier Grenier, Lindsay McCormack, Shomoukh A. Alshamekh, Denise M. Adams, Cameron C. Trenor, Meghan J. O’Hare, Marilyn G. Liang
Journal: JAMA Dermatology (2021)

Sirolimus is a mammalian target of rapamycin (mTOR) inhibitor that blocks signals from the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway, which coordinates cell proliferation and survival central to the development of vascular anomalies. 1,2 Oral sirolimus is widely used to treat varied vascular anomalies and is associated with diverse adverse events (AEs), including leukopenia, gastrointestinal symptoms, infectious complications, and dyslipidemia. 1,2 Limited data exist regarding dermatologic AEs in populations with vascular anomalies.
Realising early recognition of arthritis in times of increased telemedicine: the value of patient-reported swollen joints
Authors: Cleo Rogier, Bastiaan T van Dijk, Elisabeth Brouwer, Pascal H P de Jong, Annette H M van der Helm-van Mil
Journal: Annals of the Rheumatic Diseases (2021)

Early diagnosis and management of patients with inflammatory arthritis (IA) are critical to improve long-term patient outcomes. Assessment of joint swelling at joint examination is the reference of IA identification; early access clinics are constructed to promote this early recognition. Due to the COVID-19 pandemic, the face-to-face capacity of such services is severely reduced.1 This raises the concern of a major step backward after the important progress that has been made in the past 15 years.1 Telemedicine has recently become rapidly implemented. Although probably a valuable alternative in the management of established rheumatoid arthritis (RA), there is also the fear that this might cause delay in the speed of diagnosis.2 A symptom that evidently raises suspicion for IA during remote evaluation is the presence of patient-reported swelling. This symptom is also included in triage tools.3 4 

The accuracy of patient-reported swelling in comparison with joint examination has been extensively evaluated in established RA. Heterogeneous results are reported; correlation coefficients were higher when patient scored their swelling on mannequins (ρ: 0.31–0.67) than when determined with questions.5 Hypothetically, the accuracy of patient-reported joint swelling for first recognition of IA is different than for flare detection in patients with established RA. To promote evidence-based care in the era of telemedicine, we determined the accuracy of patient-reported joint swelling for actual presence of IA in persons suspected of …
Novel scheme for non-invasive gut bioinformation acquisition with a magnetically controlled sampling capsule endoscope
Authors: Zhen Ding, Weijun Wang, Kun Zhang, Fanhua Ming, Tianyi Yangdai, Tao Xu, Huiying Shi, Yuhui Bao, Hailing Yao, Hangyu Peng, Chaoqun Han, Weiwei Jiang, Jun Liu, Xiaohua Hou, Rong Lin
Journal: Gut (2021)

Objective Intestinal flora and metabolites are associated with multiple systemic diseases. Current approaches for acquiring information regarding microbiota/metabolites have limitations. We aimed to develop a precise magnetically controlled sampling capsule endoscope (MSCE) for the convenient, non-invasive and accurate acquisition of digestive bioinformation for disease diagnosis and evaluation. Design The MSCE and surgery were both used for sampling both jejunal and ileal GI content in the control and antibiotic-induced diarrhoea groups. The GI content was then used for microbiome profiling and metabolomics profiling. Results Compared with surgery, our data showed that the MSCE precisely acquired data regarding the intestinal flora and metabolites, which was effectively differentiated in different intestinal regions and disease models. Using MSCE, we detected a dramatic decrease in the abundance of Bacteroidetes, Patescibacteria and Actinobacteria and hippuric acid levels, as well as an increase in the abundance of Escherichia–Shigella and the 2-pyrrolidinone levels were detected in the antibiotic-induced diarrhoea model by MSCE. MSCE-mediated sampling revealed specific gut microbiota/metabolites including Enterococcus , Lachnospiraceae , acetyl-L-carnitine and succinic acid, which are related to metabolic diseases, cancers and nervous system disorders. Additionally, the MSCE exhibited good sealing characteristics with no contamination after sampling. Conclusions We present a newly developed MSCE that can non-invasively and accurately acquire intestinal bioinformation via direct visualization under magnetic control, which may further aid in disease prevention, diagnosis, prognosis and treatment.