tbuckley/cabot-search huggingface dataset:
Long-term nitroglycerin treatment: effect on direct and endothelium-mediated large coronary artery dilation in conscious dogs.
Authors: D JStewart, JHoltz, EBassenge
Journal: Circulation (1987)

We examined the effect of nitroglycerin (GTN) tolerance on an important determinant of nitrate-antianginal action, large coronary artery dilation, in 11 chronically instrumented conscious dogs. In addition, endothelium-mediated coronary artery dilation was studied because this shares a common dilator pathway with the nitrates, i.e., activation of soluble guanylate cyclase. With long-term GTN (1.5 micrograms/kg/min iv for 5 days) the diameters of the left circumflex and anterior descending coronary arteries showed an initial increase of 8.2 +/- 0.3% and 10.8 +/- 0.9%, respectively, returning to control levels by the second to third day of treatment. On days 4 and 5, the dose-response relations for GTN-induced epicardial artery dilation were shifted (p less than .01) to 17- to 20-fold higher doses. However, there was no attenuation of epicardial artery dilation induced by SIN-1 (n = 7), another activator of guanylate cyclase, or of endothelium-mediated dilation assessed both as flow-dependent dilation (n = ...
Abnormal automatic rhythms in ischemic Purkinje fibers are modulated by a specific alpha 1-adrenergic receptor subtype.
Authors: E PAnyukhovsky, M RRosen
Journal: Circulation (1991)

BACKGROUNDRecent advances in adrenergic pharmacology have made possible the identification of alpha 1-adrenergic receptor subtypes using the specific blockers chloroethylclonidine and WB 4101.METHODS AND RESULTSIn the present study, we used these two blockers to determine the mechanisms responsible for automatic rhythms occurring during simulated ischemia and reperfusion of isolated canine Purkinje fibers. Experiments were done in the presence of propranolol to minimize beta-adrenergic contributions to the rhythms studied. In the control situation, all fibers showed membrane potentials greater than -90 mV and normal automatic rhythms. During simulated ischemia, membrane potential depolarized to the -60 mV range. Abnormal automaticity was seen in 20% of fibers not treated with phenylephrine and in 50% of those superfused with 1 x 10(-7) M phenylephrine. The incidence of abnormal automaticity was reduced to 0% by WB 4101 (which blocks phosphoinositide metabolic effects of alpha 1-adrenergic stimulation in t...
Circadian variation of acute myocardial infarction and the effect of low-dose aspirin in a randomized trial of physicians.
Authors: P MRidker, J EManson, J EBuring, J EMuller, C HHennekens
Journal: Circulation (1990)

Increased platelet aggregation in the morning and upon assuming an upright posture may account at least in part for the observed circadian variation in onset of acute myocardial infarction. The Physicians' Health Study, a randomized, double-blind, placebo-controlled trial of alternate-day aspirin intake (325 mg) among 22,071 US male physicians, afforded the opportunity to assess this circadian pattern and examine whether it is altered by aspirin therapy. During a 5-year period of follow-up, 342 cases of nonfatal myocardial infarction were confirmed, of which the time of onset was available in 211 (62%). The placebo group showed a bimodal circadian variation in onset of myocardial infarction with a primary peak between 4:00 AM and 10:00 AM (p less than 0.001). In the aspirin group, however, this circadian variation was minimal (p = 0.16), due primarily to a marked reduction in the morning peak of infarction. Specifically, aspirin was associated with a 59.3% reduction in the incidence of infarction during t...
Mechanical properties of rat cardiac skinned fibers are altered by chronic growth hormone hypersecretion.
Authors: EMayoux, RVentura-Clapier, JTimsit, FBéhar-Cohen, CHoffmann, J JMercadier
Journal: Circulation Research (1993)

Chronic growth hormone (GH) hypersecretion in rats leads to increased isometric force without affecting the unloaded shortening velocity of isolated cardiac papillary muscles, despite a marked isomyosin shift toward V3. To determine if alterations occurred at the level of the contractile proteins in rats bearing a GH-secreting tumor (GH rats), we examined the mechanical properties of skinned fibers to eliminate the early steps of the excitation-contraction coupling mechanism. We found that maximal active tension and stiffness at saturating calcium concentrations (pCa 4.5) were markedly higher in GH rats than in control rats (tension, 52.9 +/- 5.2 versus 38.1 +/- 4.6 mN.mm-2, p < 0.05; stiffness, 1,105 +/- 120 versus 685 +/- 88 mN.mm-2.microns-1, p < 0.01), whereas values at low calcium concentrations (pCa 9) were unchanged. In addition, the calcium sensitivity of the contractile proteins was slightly but significantly higher in GH rats than in control rats (delta pCa 0.04, p < 0.001). The crossbridge cycl...
The potentiation of warfarin anticoagulation by amiodarone.
Authors: AHamer, TPeter, W JMandel, M MScheinman, DWeiss
Journal: Circulation (1982)

The potentiation of the anticoagulant effect of sodium warfarin by amiodarone is reported in 10 patients. Amiodarone appears to augment the depression of vitamin K-dependent coagulation factors caused by warfarin by an uncertain mechanism, and may lead to serious bleeding. The maintenance dose of warfarin should be halved when amiodarone and warfarin are prescribed together.
Mechanical determinants of maximum isotonic lengthening rate in rat left ventricular myocardium.
Authors: M RZile, W HGaasch, A WWiegner, K GRobinson, O HBing
Journal: Circulation Research (1987)

The effects of changing loading conditions and inotropic state on maximum isotonic lengthening rate (+dL/dt, muscle lengths/sec) were examined in isolated rat myocardium. Physiologically sequenced contractions were studied in 18 left ventricular papillary muscle preparations (stimulation rate, 12/min). To study the effects of changing loading conditions, only one loading variable (preload, total load, or late load) was changed during each contraction, while the others were held constant. To study the effects of isoproterenol (10(-6) M) and temperature (28 vs. 33 degrees C) on maximum isotonic lengthening rate, preload and late load were held constant and +dL/dt was examined at a common total load. When preload was increased from 0.7 +/- 0.1 to 1.4 +/- 0.1 g/mm2, muscle length increased from 0.98 +/- 0.003 to 1.01 +/- 0.002 muscle lengths, the extent of shortening increased from 0.05 +/- 0.003 to 0.08 +/- 0.003 muscle lengths, but minimum length (0.93 +/- 0.01 muscle lengths) and +dL/dt (1.1 +/- 0.1 muscle...
Abstract 12889: 1291-3 C>A Polymorphism is Linked to H558R Polymorphism: Genetic Modulators of Brugada Syndrome
Authors: Yukiko Nakano, Masaaki Toshisige, Hidenori Ochi, Noboru Oda, Yuko Uchimura-Makita, Kenta Kajihara, Takehito Tokuyama, Akinori Sairaku, Chikaaki Motoda, Mai Fujiwara, Yoshikazu Watanabe, Kazuyoshi Suenari, Kazuaki Chayama, Yasuki Kihara
Journal: Circulation (2012)

BACKGROUND: Clinical relevance of SCN5A gene polymorphisms in Brugada syndrome has not yet been completely elucidated. In this study, we investigated the clinical implication of 1291-3 C>A in intro...
Antireflux Mucosectomy (Arms) and Antireflux Mucosal Ablation (Arma) for the Treatment of Gastroesophageal Reflux Disease: a Systematic Review and Meta-Analysis
Authors: E Rodriguez de Santiago, C Teruel Sanchez-Vegazo, N Marcos Carrasco, Y Shimamura, M Tanabe, B Peñas, MJ De Higes, S Parejo, N Alvárez Díaz, S Kazuya, E Vazquez-Sequeiros, H Inoue, A Albillos
Journal: Endoscopy (2021)

Aims 1. To systematically assess the clinical success, safety and 24-h pH-metry outcomes of ARMS and ARMA in patients with GERD. 2. To compare ARMS and ARMA.
Association Between Maternal Fluoride Exposure and Child IQ
Authors: Jesse Bledsoe, David Breiger, James McKeever
Journal: JAMA Pediatrics (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Athlete's Foot
Authors: C. B. Sroka
Journal: BMJ (1956)

We designed variant human TCRs composed of the full-length TCRα/β or extracellular and transmembrane domains of the associated CD3 subunits fused to polypeptides derived from proteins thought to either enhance or inhibit normal T cell function. First, we showed that the C termini of both the TCR α- and β-chains can accommodate specific additional sequences, without abrogating complex formation or acute sensitivity of the receptor. Replacement of ITAMs with ITIM-containing intracellular domains inverted the TCR signal (i.e., created a ligand-dependent inhibitory receptor). The normal signaling function of the CD3 complex was transferable to the TCR by eliminating all CD3 ITAMs and grafting three to six ITAMs onto the C termini of the α/β-chains, with no effect on acute sensitivity. The observation that TCR variants of such diverse C-terminal composition can fold and function as signaling receptors demonstrates substantial structural and functional malleability of TCRs. These results add to knowledge about TCR structure–function with regard to acute signaling and may provide a route to use TCRs in different ways for T cell therapy.
Determinants of survival and left ventricular performance after mitral valve replacement. Department of Veterans Affairs Cooperative Study on Valvular Heart Disease.
Authors: M HCrawford, JSouchek, C AOprian, D CMiller, SRahimtoola, J CGiacomini, GSethi, K EHammermeister
Journal: Circulation (1990)

To determine how survival and clinical status were related to left ventricular (LV) size and systolic function after mitral valve replacement, 104 patients (48 mitral regurgitation [MR], 33 mitral stenosis [MS], and 23 MS/MR) with isolated mitral valve replacement were evaluated before and after surgery. Preoperative hemodynamic abnormalities by cardiac catheterization were improved 6 months after surgery in all three patient groups. The patients with MR exhibited reductions in LV end-diastolic volume index (EDVI) (117 +/- 51 to 89 +/- 27 ml/m2, p less than 0.001) and ejection fraction (EF) (0.56 +/- 0.15 to 0.45 +/- 0.13, p less than 0.001); however, the ratio of forward stroke volume to end-diastolic volume increased (0.32 +/- 0.21 to 0.45 +/- 0.17, p less than 0.001) because of the elimination of regurgitant volume. Survival analysis revealed that mortality was significantly higher in MS or MS/MR patients with postoperative EDVI more than 101 ml/m2 (p less than 0.001 and p less than 0.042, respectively...
Cimetidine and Eosinophilic Fasciitis
Authors: OSVALDO GARCÍA-MORTEO
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 February 1984Cimetidine and Eosinophilic FasciitisOSVALDO GARCÍA-MORTEO, M.D., JOSÉ A. MALDONADO-COCCO, M.D., JUAN C. BARREIRA, M.D., HÉCTOR A. BARCELÓ, M.D.OSVALDO GARCÍA-MORTEO, M.D.Search for more papers by this author, JOSÉ A. MALDONADO-COCCO, M.D.Search for more papers by this author, JUAN C. BARREIRA, M.D.Search for more papers by this author, HÉCTOR A. BARCELÓ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-2-318_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Solomon and associates (1) recently reported the case of a patient with eosinophilic fasciitis who showed a prompt and complete response to treatment with cimetidine, and they suggested that cimetidine may be an alternative therapy. We report two more cases of eosinophilic fasciitis with apparent cimetidine-induced remission.A 58-year-old woman with biopsy-proven eosinophilic fasciitis was referred to us because of relapses of disease after attempts to discontinue steroid treatments. The patient had a 12-month history of swelling and induration of the hands, forearms, and legs, and diffuse arthralgias and myalgias. Laboratory data showed a leukocyte count of...References1. SOLOMONBARLANDRIFKIN GPH. Eosinophilic fasciitis responsive to cimetidine. Ann Intern Med. 1982;97:547-9. LinkGoogle Scholar2. BARNESRODNANMEDSGERSHORT LGTD. Eosinophilic fasciitis: a pathologic study of twenty cases. Am J Pathol. 1979;96:493-518. MedlineGoogle Scholar3. MICHETDOYLEGINSBURG CJW. Eosinophilic fasciitis: report of 15 cases. Mayo Clin Proc. 1981;56:27-34. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: OSVALDO GARCÍA-MORTEO, M.D.; JOSÉ A. MALDONADO-COCCO, M.D.; JUAN C. BARREIRA, M.D.; HÉCTOR A. BARCELÓ, M.D.Affiliations: Instituto Nacional de Rehabilitación Echeverría 955; 1428 Buenos Aires Argentina PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEosinophilic Fasciitis in a Pediatric PatientThe Fasciitis-Panniculitis Syndromes Clinical and Pathologic FeaturesA Case of Eosinophilic Fasciitis.Pathogenesis of Lipodermatosclerosis of Venous Disease: The Lesson Learned from Eosinophilic FasciitisKetotifen - a therapeutic agent of eosinophilic fasciitis?The fasciitis-panniculitis syndrome: Clinical spectrum and response to cimetidineInflammatory Pseudotumor of the NeckThe Mast Cell in FibrosisTreatment with cimetidine of atypical fasciitis panniculitis syndrome.Cimetidine in Eosinophilie FasciitisHerson Serge, MD, Sabine Brechignac, MD, Godeau Pierre, MDDermatologic therapy: December 1983 through November 1984 1 February 1984Volume 100, Issue 2Page: 318-319KeywordsArthralgiaInflammationMyalgiaPatientsResearch laboratories ePublished: 1 December 2008 Issue Published: 1 February 1984 PDF downloadLoading ...
The displacement cardiograph. A noninvasive technique for recording myocardial wall motion.
Authors: T CGay, RVas, D EPittman, C RJoyner
Journal: Circulation (1976)

The displacement cardiograph (DCG) is a noninvasive device employing an electromagnetic field to record tissue motion within the body. The sensing coil need not be in contact with the patient since the field penetrates air and stationary tissue without significant distortion. Disturbances in the field with result from ventricular wall motion are electronically converted to an analog output and a pattern inscribed on the paper of a physiological recorder. In an attempt to determine the reliability of the DCG in detecting regional areas of abnormal left ventricular wall motion, displacement cardiograms were obtained from 70 patients who underwent cardiac catheterization and left ventriculography. The DCG interpretations were in agreement with the ventriculographic picture of left ventricular wall motion in 67 of the 70 patients. There were two false positive and one false negative DCG diagnoses. The results indicate that the DCG can be employed as a reliable noninvasive method for repetitive assessment of t...
Abstract 13172: Personalized Antiplatelet Therapy Guided by a Novel Detection of Platelet Aggregation Function in Stable Coronary Artery Disease Patients Undergoing Pci: A Randomized Controlled Clinical Trial
Authors: Ying-Ying Zheng, Ting-Ting Wu, Yi Yang, Xian-Geng Hou, Ying Gao, You Chen, Yi-Ning Yang, Xiao-Mei Li, Xiang Ma, Yi-Tong Ma, Xiang Xie
Journal: Circulation (2019)

Background: A number of studies have attempted to demonstrate the benefits associated with personalized antiplatelet therapy guided by platelet function testing (PFT), which has led to disappointin...
Noninvasive identification of myocardium at risk in patients with acute myocardial infarction and nondiagnostic electrocardiograms with technetium-99m-Sestamibi.
Authors: T FChristian, I PClements, R JGibbons
Journal: Circulation (1991)

BACKGROUNDPatients who have chest pain without electrocardiographic ST elevation are not candidates for thrombolytic therapy in most clinical trials. This study examined the value of technetium-99m-Sestamibi tomographic imaging to assess myocardial perfusion in patients during chest pain without ST elevation.METHODS AND RESULTSTc-99m-Sestamibi was injected in 14 patients who had chest pain without ST elevation, who subsequently developed enzymatic evidence of myocardial infarction within 24 hours. Tomographic imaging was performed 1-6 hours after injection. Thirteen of 14 patients showed significant perfusion defects indicative of acute myocardial infarction consistent with absent perfusion (20 +/- 15% of the left ventricle; range, 2-53%); one patient had normal images. Because of the absence of definitive electrocardiographic changes, only five patients received reperfusion therapy within 6 hours of the onset of chest pain. Regional wall motion abnormalities were present in nine of nine patients undergoi...
Successful Endoscopic Closure of a Residual Fistula after Esophageal Atresia Repair in A 5-Year Child Using ESD of the Surrounding Mucosa
Authors: M Pioche, S Heissat, G Lavaud
Journal: Endoscopy (2021)

We present the case of a patient of 5 years old, with history of type III atresia neonatal surgery, with chronic respiratory congestion and poor weight gain due to a large tracheooesophageal defect.
Comparative effects of nicardipine, a new calcium antagonist, on size of myocardial infarction after coronary artery occlusion in dogs.
Authors: TEndo, JNejima, SFujita, KKiuchi, NIida, KKikuchi, HHayakawa, HOkumura
Journal: Circulation (1986)

To examine whether nicardipine, a dihydropyridine derivative, limits size of myocardial infarction, and to compare the protective effects of nicardipine administered before and early and late after coronary artery occlusion, 99mTc-labeled albumin microspheres were injected into the left atrium during 5 min temporary coronary artery occlusion to determine the extent of the hypoperfused zone (the area at risk). The coronary arteries were then reperfused for 45 min before 6 hr permanent coronary artery occlusion. Fifteen minutes before permanent occlusion, dogs were randomly assigned to a control group (n = 11), a pretreatment group (n = 9), which received at this point 10 micrograms/kg of nicardipine as a loading dose followed by a continuous infusion of 8 micrograms/kg/hr for 6 hr, an early treatment group (n = 9), in which nicardipine treatment was initiated 15 min after occlusion, or a late treatment group (n = 8), in which nicardipine administration was delayed for 3 hr. Six hours after coronary artery ...
Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice
Authors: Naofumi Ito, M. Asrafuzzaman Riyadh, Shah Adil Ishtiyaq Ahmad, Satoko Hattori, Yonehiro Kanemura, Hiroshi Kiyonari, Takaya Abe, Yasuhide Furuta, Yohei Shinmyo, Naoko Kaneko, Yuki Hirota, Giuseppe Lupo, Jun Hatakeyama, Felemban Athary Abdulhaleem M, Mohammad Badrul Anam, Masahiro Yamaguchi, Toru Takeo, Hirohide Takebayashi, Minoru Takebayashi, Yuichi Oike, Naomi Nakagata, Kenji Shimamura, Michael J. Holtzman, Yoshiko Takahashi, Francois Guillemot, Tsuyoshi Miyakawa, Kazunobu Sawamoto, Kunimasa Ohta
Journal: Science Translational Medicine (2021)

The lateral ventricle (LV) is flanked by the subventricular zone (SVZ), a neural stem cell (NSC) niche rich in extrinsic growth factors regulating NSC maintenance, proliferation, and neuronal differentiation. Dysregulation of the SVZ niche causes LV expansion, a condition known as hydrocephalus; however, the underlying pathological mechanisms are unclear. We show that deficiency of the proteoglycan Tsukushi (TSK) in ependymal cells at the LV surface and in the cerebrospinal fluid results in hydrocephalus with neurodevelopmental disorder-like symptoms in mice. These symptoms are accompanied by altered differentiation and survival of the NSC lineage, disrupted ependymal structure, and dysregulated Wnt signaling. Multiple TSK variants found in patients with hydrocephalus exhibit reduced physiological activity in mice in vivo and in vitro. Administration of wild-type TSK protein or Wnt antagonists, but not of hydrocephalus-related TSK variants, in the LV of TSK knockout mice prevented hydrocephalus and preserved SVZ neurogenesis. These observations suggest that TSK plays a crucial role as a niche molecule modulating the fate of SVZ NSCs and point to TSK as a candidate for the diagnosis and therapy of hydrocephalus.
The new consultant contract
Authors: D H. Smith, T J Deeble, J A. Amos, D Bryden, F M Elderkin, W D Paterson, T G Girdwood, R McNeill, A Inglis, E Carr-Saunders, J. Wright, J Chaterjee, R J C Southern, R L McMillan, J T Taylor, S C Banerjee, E J MacDougall, T M Singh, J N Haworth, F B Buckley, C F Rolland, J. Wood, C. Salter
Journal: BMJ (1979)
A Mini-Symposium on Acupuncture
Authors: Phillip Shapiro
Journal: JAMA (1974)

To  Editor.—  Thoracic surgery, which less than ten years ago was thought to require  placement of as many as 40 needles, is now being accomplished with only one needle with no less satisfactory results ( Chinese Med J 2:17, 1973).  In  same issue, a report from  Shanghai First People's Hospital on acupuncture anesthesia in thyroidectomy reviews  results of using 12 different sets of acupuncture points in 700 cases. All were satisfactory, but  authors concluded that the results with  futu set in  region of  dermatome over  thyroid gland were distinctly better than  other sets.  These and other reports indicate that  analgesia secured by acupuncture is more than a matter of suggestibility, albeit  importance of  psychological preparation of  patient is readily accepted.  In  People's Republic of China in  summer of 1972,I witnessed various applications of acupuncture
Correlates of left ventricular mass in a population sample aged 36 to 37 years. Focus on lifestyle and salt intake.
Authors: MKupari, PKoskinen, JVirolainen
Journal: Circulation (1994)

BACKGROUNDEchocardiographically determined left ventricular (LV) mass predicts adverse cardiovascular events in the general population. We have assessed the correlates of LV mass in a population-based study focusing on lifestyle and salt intake.METHODS AND RESULTSA random sample of 120 persons born in 1954 was invited; 93 (42 men) entered the study. The subjects' physical activity and alcohol, tobacco, and coffee consumption were quantified by 2-month dairy follow-up, and sodium intake was quantified by 7-day food records. Blood pressure was averaged for casual cuff measurements made 2 months apart. LV mass was determined by M-mode echocardiography, and stroke volume was determined by Doppler. Hematocrit and serum insulin were measured. In multiple linear regression analysis, LV mass was related positively and independently (P < .05) to body weight, systolic blood pressure, stroke volume, sodium intake, hematocrit, and energy expenditure in leisure-time physical activity. Additional analyses showed that t...