Aortic Stenosis as an Additional Finding in Low-Dose Computed Tomography Lung Cancer Screening: A Cross-Sectional Study
Authors: Kaja Klein-Awerjanow, Witold Rzyman, Marcin Ostrowski, Jadwiga Fijalkowska, Edyta Szurowska, Marcin Fijalkowski
Journal: Annals of Internal Medicine (2021)

LettersOctober 2021Aortic Stenosis as an Additional Finding in Low-Dose Computed Tomography Lung Cancer Screening: A Cross-Sectional StudyKaja Klein-Awerjanow, MD, Witold Rzyman, MD, PhD, Marcin Ostrowski, MD, PhD, Jadwiga Fijalkowska, MD, Edyta Szurowska, MD, PhD, and Marcin Fijalkowski, MD, PhDKaja Klein-Awerjanow, MDMedical University of Gdansk, Gdansk, Poland, Witold Rzyman, MD, PhDMedical University of Gdansk, Gdansk, Poland, Marcin Ostrowski, MD, PhDMedical University of Gdansk, Gdansk, Poland, Jadwiga Fijalkowska, MDMedical University of Gdansk, Gdansk, Poland, Edyta Szurowska, MD, PhDMedical University of Gdansk, Gdansk, Poland, and Marcin Fijalkowski, MD, PhDMedical University of Gdansk, Gdansk, PolandAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M20-5507 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: The main purpose of low-dose computed tomography (LDCT) is to detect pulmonary nodules at significantly reduced radiation levels compared with routine CT. In addition to detecting pulmonary nodules, as an imaging biomarker of lung cancer, LDCT has been described as useful for identifying the early stages of chronic obstructive pulmonary disease and coronary artery disease (the Big-3) (1). These reports inspired us to evaluate aortic valve calcification (AVC) in LDCT.Objective: To assess the usefulness of LDCT performed for a lung cancer screening program in determining the degree of AVC as an additional finding, which could correspond with clinically ...References1. Heuvelmans MA, Vonder M, Rook M, et al. Screening for early lung cancer, chronic obstructive pulmonary disease, and cardiovascular disease (the big-3) using low-dose chest computed tomography: current evidence and technical considerations. J Thorac Imaging. 2019;34:160-169. [PMID: 30550403] doi:10.1097/RTI.0000000000000379 CrossrefMedlineGoogle Scholar2. Ostrowski M, Marjanski T, Dziedzic R, et al. Ten years of experience in lung cancer screening in Gdansk, Poland: a comparative study of the evaluation and surgical treatment of 14 200 participants of 2 lung cancer screening programmes. Interact Cardiovasc Thorac Surg. 2019. [PMID: 30887048] doi:10.1093/icvts/ivz079 CrossrefMedlineGoogle Scholar3. Baumgartner H, Falk V, Bax JJ, et al; ESC Scientific Document Group. 2017 ESC/EACTS Guidelines for the management of valvular heart disease. Eur Heart J. 2017;38:2739-2791. [PMID: 28886619] doi:10.1093/eurheartj/ehx391 CrossrefMedlineGoogle Scholar4. Clavel MA, Pibarot P, Messika-Zeitoun D, et al. Impact of aortic valve calcification, as measured by MDCT, on survival in patients with aortic stenosis: results of an international registry study. J Am Coll Cardiol. 2014;64:1202-13. [PMID: 25236511] doi:10.1016/j.jacc.2014.05.066 CrossrefMedlineGoogle Scholar5. Lee HY, Kim SM, Lee KS, et al. Quantification of aortic valve calcifications detected during lung cancer-screening CT helps stratify subjects necessitating echocardiography for aortic stenosis diagnosis. Medicine (Baltimore). 2016;95:e3710. [PMID: 27175713] doi:10.1097/MD.0000000000003710 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Medical University of Gdansk, Gdansk, PolandNote: Dr. Klein-Awerjanow confirms that the Institutional Review Board approved the study before data collection.Grant Support: This study was a collateral study to the MOLTEST BIS program funded by the National Center for Research and Development (Narodowe Centrum Badan i Rozwoju) grant PBS3/A7/29/2015/ID-247184. No direct financial funding supported this study.Disclosures: Authors have reported no disclosures of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M20-5507.Reproducible Research Statement: Study protocol, statistical code, and data set: Not available.Corresponding Author: Marcin Fijalkowski, MD, PhD, First Department of Cardiology, Medical University of Gdansk, M. Sklowskiej-Curie 3a, Gdansk 80-210, Poland; e-mail, [email protected]edu.pl.This article was published at Annals.org on 8 June 2021. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAssessment of Calcium Score Cutoff Point for Clinically Significant Aortic Stenosis on Lung Cancer Screening Program Low-Dose Computed Tomography—A Cross-Sectional Analysis October 2021Volume 174, Issue 10Page: 1482-1483KeywordsAortic valveCalciumCardiovascular therapyComputed axial tomographyEchocardiographyLung and intrathoracic tumorsLung cancer screeningPatientsPulmonary imagingStenosis ePublished: 8 June 2021 Issue Published: October 2021 Copyright & PermissionsCopyright © 2021 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...