tbuckley/cabot-search huggingface dataset:
SAT0206 Dynamic magnetic resonance imaging of the wrist: a comparison of patients with active rheumatoid arthritis, rheumatoid arthritis in remission, and psoriatic arthritis
Authors: MA Cimmino, A Iozzelli, F Magnaguagno, M Parodi, C Gandolfo, T Maio, E Silvestri, M Palazzolo, S Innocenti, G Garlaschi
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> Objective quantification of synovial membrane inflammation is an important goal of rheumatology research. Recently, magnetic resonance imaging (MRI) has been used to evaluate synovitis in rheumatoid arthritis (RA).<sup>1,2</sup> <h3>Objectives</h3> Our work is concerned with an evaluation of synovitis in patients with active RA, RA in remission, and psoriatic arthritis (PsA) in comparison with normal controls (CO). <h3>Methods</h3> 16 patients with RA according to the 1987 ACR criteria, of whom 5 were in complete clinical remission, 6 patients with PsA, and 2 CO were studied. MRI was performed with a 0.2T dedicated device (Artoscan, Esaote, Genova, Italy). The sequence used was a Spin Echo (TR/TE = 100/16 ms, matrix = 160 × 128, FOV = 50 × 150, slice thickness = 5 mm). A bolus of 0.2 ml/kg of gadopentetate dimeglumine was injected intravenously and fast images of three slices of the wrist were repeated every 20? thereafter. The enhancement ratio was calculated both as rate of early enhancement (REE) and as relative enhancement (RE). The signals from a small circular ROI in the region of maximal enhancement and from a larger segmented region including most of the enhanced synovial membrane were evaluated. The signal was normalised to the bone to reduced noise. <h3>Results</h3> Both REE and RE were significantly higher in active RA vs. inactive RA (p = 0.003), PsA (p = 0.002), and CO (p = 0.0002). In addition, RE and REE were higher in inactive RA than in CO (p = 0.008). Results from the analyses using the small ROI and the segmented ROI showed a good correlation (mean R = 0.75). REE resulted slightly more sensitive than RE. <h3>Conclusion</h3> Dynamic MRI is a useful method to evaluate synovitis by allowing quantitative estimation of the synovial enhancement. This promising technique is able to differentiate active from inactive RA, as well as RA from PsA and CO. The evaluation of a small area of the synovial membrane seems to be equally effective than the more time-consuming segmentation. <h3>References</h3> Cimmino MA, <i>et al</i>. Semin Arthritis Rheum. 2000;30:180–95 Klarlund M, <i>et al</i>. Scand J Rheumatol. 2000;29:108–15
CRISPR Mediated <i>ELANE</i> Single-Allele Knock-out Restores Proliferation and Myeloid Differentiation of Neutropenia Patient Derived BM HSCs
Authors: Peter Sabo, Vahagn Makaryan, Tanoya Poulsen, Lital Povodovski, Yosef Dicken, Asael Herman, Rafi Emmanuel, David C. Dale
Journal: Blood (2020)
Reduced Insulin Sensitivity in Patients with Myeloid Malignancies and Clonal Hematopoiesis Mutations
Authors: Uttam K. Rao, Heidi Chen, Katie S. Gatwood, Michael T. Byrne, Salyka M. Sengsayadeth, Stacey A. Goodman, Bhagirathbhai Dholaria, Adetola A. Kassim, Bipin N. Savani, Wichai Chinratanalab, Kathryn A. Culos, Michael R. Savona, Brian G. Engelhardt
Journal: Blood (2020)
The matrix metalloproteinase inhibitor IPR-179 has antiseizure and antiepileptogenic effects
Authors: Diede W.M. Broekaart, Alexandra Bertran, Shaobo Jia, Anatoly Korotkov, Oleg Senkov, Anika Bongaarts, James D. Mills, Jasper J. Anink, Jesús Seco, Johannes C. Baayen, Sander Idema, Elodie Chabrol, Albert J. Becker, Wytse J. Wadman, Teresa Tarragó, Jan A. Gorter, Eleonora Aronica, Roger Prades, Alexander Dityatev, Erwin A. van Vliet
Journal: Journal of Clinical Investigation (2020)

Matrix metalloproteinases (MMPs) are synthesized by neurons and glia and released into the extracellular space, where they act as modulators of neuroplasticity and neuroinflammatory agents. Development of epilepsy (epileptogenesis) is associated with increased expression of MMPs, and therefore, they may represent potential therapeutic drug targets. Using quantitative PCR (qPCR) and immunohistochemistry, we studied the expression of MMPs and their endogenous inhibitors tissue inhibitors of metalloproteinases (TIMPs) in patients with status epilepticus (SE) or temporal lobe epilepsy (TLE) and in a rat TLE model. Furthermore, we tested the MMP2/9 inhibitor IPR-179 in the rapid-kindling rat model and in the intrahippocampal kainic acid mouse model. In both human and experimental epilepsy, MMP and TIMP expression were persistently dysregulated in the hippocampus compared with in controls. IPR-179 treatment reduced seizure severity in the rapid-kindling model and reduced the number of spontaneous seizures in the kainic acid model (during and up to 7 weeks after delivery) without side effects while improving cognitive behavior. Moreover, our data suggest that IPR-179 prevented an MMP2/9-dependent switch-off normally restraining network excitability during the activity period. Since increased MMP expression is a prominent hallmark of the human epileptogenic brain and the MMP inhibitor IPR-179 exhibits antiseizure and antiepileptogenic effects in rodent epilepsy models and attenuates seizure-induced cognitive decline, it deserves further investigation in clinical trials.
ECOG Performance Status Shows a Stronger Association with Treatment Tolerability Than Some Multidimensional Scales in Elderly Patients Diagnosed with Hematological Malignancies
Authors: Fernando Ramos, Marta Castellanos, Natalia De las Heras, Fernando Escalante, Silvia Fernandez-Ferrero, Maria Jesus Vidal, Maria Lavinia Villalobos
Journal: Blood (2020)
Safety and Efficacy of CTX001 in Patients with Transfusion-Dependent β-Thalassemia and Sickle Cell Disease: Early Results from the Climb THAL-111 and Climb SCD-121 Studies of Autologous CRISPR-CAS9-Modified CD34+ Hematopoietic Stem and Progenitor Cells
Authors: Haydar Frangoul, Yael Bobruff, Maria Domenica Cappellini, Selim Corbacioglu, Christine Marie Fernandez, Josu de la Fuente, Stephan A Grupp, Rupert Handgretinger, Tony W. Ho, Suzan Imren, Antonis Kattamis, Julie Lekstrom-Himes, Franco Locatelli, Yimeng Lu, Markus Y Mapara, Mariane de Montalembert, Sarah D. Mulcahey, Damiano Rondelli, Niraj Shanbhag, Sujit Sheth, Sandeep Soni, Martin H. Steinberg, Michael J. Weinstein, John K. Wu, Donna Wall
Journal: Blood (2020)
Malignant Progression of Monoclonal Gammopathy of Undetermined Significance: A Systematic Review and Meta-Analysis
Authors: Soon Khai Low, Tarek Soliman Khattab, Ali Hussein Dawood, Rawan Al khudari, Esraa Mahmoud Mostafa, Amr Elhamamsy, Amr Ebied, Shin Yin Lee, Nguyen Tien Huy
Journal: Blood (2020)
Pharmacokinetic and Pharmacodynamic Correlates from the Phase 1 Study of Camidanlumab Tesirine (Cami) in Patients with Relapsed or Refractory Hodgkin Lymphoma and Non-Hodgkin Lymphoma
Authors: Joseph Boni, Karin Havenith, Mehdi Hamadani, Paolo F Caimi, Katie Anderson, Tim Kopotsha, Hans G Cruz, Jens Wuerthner
Journal: Blood (2020)
Use of Post-Transplant Cyclophosphamide in One-Antigen Mismatched Unrelated Donor Transplantation Results in Similar Transplant Outcomes Than Haploidentical Hransplantation: A Retrospective Study on Behalf of the Acute Leukemia Working Party of the EBMT
Authors: Giorgia Battipaglia, Jacques-Emmanuel Galimard, Myriam Labopin, Emanuele Angelucci, Didier Blaise, Annalisa Ruggeri, Zafer Gulbas, José Luis Díez-Martín, Yener Koc, Luca Castagna, Antonin Vitek, Simona Sica, Benedetto Bruno, Ivan S. Moiseev, Montserrat Rovira, Massimo Martino, Mercedes Colorado Araujo, Mutlu Arat, Giovanni Grillo, Hans Martin, Lucía López Corral, Fabrizio Pane, Fabio Ciceri, Arnon Nagler, Mohamad Mohty
Journal: Blood (2020)
Retrospective Real-World Analysis of the Primary Safety Outcomes in Venous Thromboembolism of High-Risk Major Bleeding Cancer Patients Receiving Therapeutic Anticoagulation
Authors: Eric Brucks Brucks, Sumana Veeravelli, Ritika Halder, Francisco Javier Martinez, Jorge Andres Leiva, Kathylynn Saboda, Denise Roe, Hani M. Babiker, Ali McBride, Alejandro Recio-Boiles
Journal: Blood (2020)
Transcutaneous auricular vagus nerve stimulation reduces pain and fatigue in patients with systemic lupus erythematosus: a randomised, double-blind, sham-controlled pilot trial
Authors: Cynthia Aranow, Yemil Atish-Fregoso, Martin Lesser, Meggan Mackay, Erik Anderson, Sangeeta Chavan, Theodoros P Zanos, Timir Datta-Chaudhuri, Chad Bouton, Kevin J Tracey, Betty Diamond
Journal: Annals of the Rheumatic Diseases (2020)

Objectives Musculoskeletal pain and fatigue are common features in systemic lupus erythematosus (SLE). The cholinergic anti-inflammatory pathway is a physiological mechanism diminishing inflammation, engaged by stimulating the vagus nerve. We evaluated the effects of non-invasive vagus nerve stimulation in patients with SLE and with musculoskeletal pain. Methods 18 patients with SLE and with musculoskeletal pain ≥4 on a 10 cm Visual Analogue Scale were randomised (2:1) in this double-blind study to receive transcutaneous auricular vagus nerve stimulation (taVNS) or sham stimulation (SS) for 4 consecutive days. Evaluations at baseline, day 5 and day 12 included patient assessments of pain, disease activity (PtGA) and fatigue. Tender and swollen joint counts and the Physician Global Assessment (PGA) were completed by a physician blinded to the patient’s therapy. Potential biomarkers were evaluated. Results taVNS and SS were well tolerated. Subjects receiving taVNS had a significant decrease in pain and fatigue compared with SS and were more likely (OR=25, p=0.02) to experience a clinically significant reduction in pain. PtGA, joint counts and PGA also improved. Pain reduction and improvement of fatigue correlated with the cumulative current received. In general, responses were maintained through day 12. Plasma levels of substance P were significantly reduced at day 5 compared with baseline following taVNS but other neuropeptides, serum and whole blood-stimulated inflammatory mediators, and kynurenine metabolites showed no significant change at days 5 or 12 compared with baseline. Conclusion taVNS resulted in significantly reduced pain, fatigue and joint scores in SLE. Additional studies evaluating this intervention and its mechanisms are warranted.
RARγ activation sensitizes human myeloma cells to carfilzomib treatment through the OAS-RNase L innate immune pathway
Authors: Qiang Wang, Zhijuan Lin, Zhuo Wang, Lingqun Ye, Miao Xian, Liuling Xiao, Pan Su, Enguang Bi, Yung-hsing Huang, Jianfei Qian, Lintao Liu, Xingzhe Ma, Maojie Yang, Wei Xiong, Youli Zu, Sai Ravi Pingali, Bing Xu, Qing Yi
Journal: Blood (2021)
Assessment of familial risk in patients with hidradenitis suppurativa
Authors: R. L. Bruinsma, K. Fajgenbaum, Y. Yang, M. Mar Melendez‐Gonzalez, K. L. Mohlke, Y. Li, C. Sayed
Journal: British Journal of Dermatology (2020)

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder resulting in recurrent, painful nodules, abscesses, and sinuses with predilection for intertriginous sites.1 In previous cohorts relying primarily on chart review, 30-40% of patients reported family history of disease,2 but familial risk has not been formally assessed with more meticulous and focused data collection. 676 HS patients at the University of North Carolina Chapel Hill were enrolled in our clinical registry from August 2018-December 2019, which collected detailed family history data using questionnaires and skilled interviewers. 57.5% of patients reported HS in either first- or second-degree relatives, including 49.5% with an affected first-degree relative. This suggests a possible genetic contribution to HS. This study's aim was to quantify familial risk in patients with HS.
Covid-19: Study findings strongly support use of pooled testing, say researchers
Authors: Gareth Iacobucci
Journal: BMJ (2020)

Study findings strongly support use of pooled testing, say researchers Gareth IacobucciPooled testing could be an efficient and effective way of processing large numbers of covid-19 tests, a preprint study 1 has reported.Pooling has been proposed as a strategy to reduce costs and increase throughput of tests.The process-which involves mixing several samples together, testing the pooled sample, and testing people in the group individually if the result comes back positive-has already been deployed at some UK universities to help stop outbreaks and keep campuses open. 2
Offline: Managing the COVID-19 vaccine infodemic
Authors: Richard Horton
Journal: The Lancet (2020)

If you read News Punch (aka "Where mainstream fears to tread"), you will be familiar with a series of articles about the prospects for a COVID-19 vaccine. With headlines such as "Big Pharma Exec: We Are Exempt From COVID-19 Vaccine Liability Claims", the website has published report after report casting doubt on the integrity of vaccine science and even the likelihood of a vaccine becoming available. You will find similar pieces on other websites, such as Infowars and AlterNet. The arguments these articles peddle seem deliberately designed to sow uncertainty.
Depth of Response and Response Kinetics of Isatuximab Plus Carfilzomib and Dexamethasone in Relapsed Multiple Myeloma: Ikema Interim Analysis
Authors: Thomas Martin, Joseph Mikhael, Roman Hajek, Kihyun Kim, Kenshi Suzuki, Cyrille Hulin, Mamta Garg, Hang Quach, Hanlon Sia, Anup George, Tatiana Konstantinova, Marie-Laure Risse, Gaelle Asset, Sandrine Macé, Helgi van de Velde, Philippe Moreau
Journal: Blood (2020)
Bariatric Surgery Versus Standard Obesity Treatment and the Risk of Severe Liver Disease: Data From the Swedish Obese Subjects Study
Authors: Hannes Hagström, Mattias Ekstedt, Torsten Olbers, Markku Peltonen, Lena Carlsson
Journal: Clinical Gastroenterology and Hepatology (2020)

Obesity is closely associated with nonalcoholic fatty liver disease. A minority of patients with nonalcoholic fatty liver disease progress to liver cirrhosis and end-stage liver disease.1 Weight loss results in improvement of liver histology in persons with nonalcoholic fatty liver disease.2 Because weight loss can be challenging to achieve and sustain in persons with obesity, bariatric surgery is considered a feasible therapeutic option for persons with severe obesity.3 Bariatric surgery leads to improved glucose tolerance, weight loss, and improved overall mortality.4 It is less well known if bariatric surgery also reduces the incidence of liver-related outcomes. Here, we analyzed liver-related outcomes in the Swedish Obese Subjects (SOS) cohort.5.
Effectiveness and Safety of Apixaban Vs Warfarin Among Venous Thromboembolism Patients Using Five US Databases: A Subgroup Analysis of Obesity
Authors: Alexander T Cohen, Janvi Sah, Theodore Lee, Gail Wygant, Lisa Rosenblatt, Patrick Hlavacek, Birol Emir, Allison Keshishian, Rachel Delinger, Xuemei Luo
Journal: Blood (2020)
Inhibition of G Protein–Coupled Receptor Kinase 2 Promotes Unbiased Downregulation of IGF1 Receptor and Restrains Malignant Cell Growth
Authors: Caitrin Crudden, Takashi Shibano, Dawei Song, Mihnea P. Dragomir, Sonia Cismas, Julianna Serly, Daniela Nedelcu, Enrique Fuentes-Mattei, Andrei Tica, George A. Calin, Ada Girnita, Leonard Girnita
Journal: Cancer Research (2020)

Abstract The ability of a receptor to preferentially activate only a subset of available downstream signal cascades is termed biased signaling. Although comprehensively recognized for the G protein–coupled receptors (GPCR), this process is scarcely explored downstream of receptor tyrosine kinases (RTK), including the cancer-relevant insulin-like growth factor-1 receptor (IGF1R). Successful IGF1R targeting requires receptor downregulation, yet therapy-mediated removal from the cell surface activates cancer-protective β-arrestin–biased signaling (β-arr-BS). As these overlapping processes are initiated by the β-arr/IGF1R interaction and controlled by GPCR-kinases (GRK), we explored GRKs as potential anticancer therapeutic targets to disconnect IGF1R downregulation and β-arr-BS. Transgenic modulation demonstrated that GRK2 inhibition or GRK6 overexpression enhanced degradation of IGF1R, but both scenarios sustained IGF1–induced β-arr-BS. Pharmacologic inhibition of GRK2 by the clinically approved antidepressant, serotonin reuptake inhibitor paroxetine (PX), recapitulated the effects of GRK2 silencing with dose- and time-dependent IGF1R downregulation without associated β-arr-BS. In vivo, PX treatment caused substantial downregulation of IGF1R, suppressing the growth of Ewing's sarcoma xenografts. Functional studies reveal that PX exploits the antagonism between β-arrestin isoforms; in low ligand conditions, PX favored β-arrestin1/Mdm2-mediated ubiquitination/degradation of IGF1R, a scenario usually exclusive to ligand abundancy, making PX more effective than antibody-mediated IGF1R downregulation. This study provides the rationale, molecular mechanism, and validation of a clinically feasible concept for “system bias” targeting of the IGF1R to uncouple downregulation from signaling. Demonstrating system bias as an effective anticancer approach, our study reveals a novel strategy for the rational design or repurposing of therapeutics to selectively cross-target the IGF1R or other RTK. Significance: This work provides insight into the molecular and biological roles of biased signaling downstream RTK and provides a novel “system bias” strategy to increase the efficacy of anti–IGF1R-targeted therapy in cancer.
Overexpression of <i>hTLX3</i> in Association with Mutant <i>IL7Rα</i> Is Sufficient to Generate T-ALL <i>In Vivo</i> and to Transform Thymocytes <i>in</i> <i>Vitro</i>
Authors: Gisele Olinto Libanio Rodrigues, Julie Hixon, Hila Winer, Erica Matich, Caroline Andrews, Sarah Cramer, Wenqing Li, Scott Durum
Journal: Blood (2020)
Allogeneic Transplant Conditioning Regimens for Patients With Non-Hodgkin Lymphoma—Reply
Authors: Mehdi Hamadani, Carlos Litovich, Kwang Woo Ahn
Journal: JAMA Oncology (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Association between Native Myocardial T1 Mapping and Cardiac Function and Macroscopic Fibrosis in Thalassemia Major
Authors: Alessia Pepe, Nicola Martini, Antonio De Luca, Vincenzo Positano, Laura Pistoia, Giovan Battista Ruffo, Marilena Serra, Calogera Gerardi, Monica Benni, Crocetta Argento, Aurelio Maggio, Gianfranco Sinagra, Antonella Meloni
Journal: Blood (2020)
The Impact of Race and Ethnicity on Diffuse Large B-Cell Lymphoma (DLBCL) Outcomes within the Veterans Health Administration (VHA)
Authors: Madison H. Williams, Ryan A. Williams, Jean Pierre Blaize, Snegha Ananth, David Gregorio, Gerardo Manuel Rosas, Michael M. Song, Brian Warnecke, Abhishek Pandya, Lakene Raissa Djoufack Djoumessi, Vivian Dee, Phillip Nazarewicz, Kathleen Franklin, Juan J. Toro, Michael Mader, Zohra Nooruddin
Journal: Blood (2020)
High soluble transferrin receptor in patients with heart failure: a measure of iron deficiency and a strong predictor of mortality
Authors: Radoslaw Sierpinski, Krystian Josiak, Tomasz Suchocki, Katarzyna Wojtas‐Polc, Grzegorz Mazur, Aleksandra Butrym, Piotr Rozentryt, Peter van der Meer, Josep Comin‐Colet, Stephan von Haehling, Wojciech Kosmala, Monika Przewlocka‐Kosmala, Waldemar Banasiak, Jolanta Nowak, Adriaan A. Voors, Stefan D. Anker, John G.F. Cleland, Piotr Ponikowski, Ewa A. Jankowska
Journal: European Journal of Heart Failure (2020)
Cancer Care Disparities during the COVID-19 Pandemic: COVID-19 and Cancer Outcomes Study
Authors: Andrew L. Schmidt, Ziad Bakouny, Sheena Bhalla, John A. Steinharter, Douglas A. Tremblay, Mark M. Awad, Alaina J. Kessler, Robert I. Haddad, Michelle Evans, Fiona Busser, Michael Wotman, Catherine R. Curran, Brittney S. Zimmerman, Gabrielle Bouchard, Tomi Jun, Pier V. Nuzzo, Qian Qin, Laure Hirsch, Jonathan Feld, Kaitlin M. Kelleher, Danielle Seidman, Hsin-Hui Huang, Heather M. Anderson-Keightly, Sarah Abou Alaiwi, Talia D. Rosenbloom, Penina S. Stewart, Matthew D. Galsky, Toni K. Choueiri, Deborah B. Doroshow
Journal: Cancer Cell (2020)
<i>The Association between Asparaginase Enzyme Activity Levels and Toxicities in Childhood Acute Lymphoblastic Leukaemia in the NOPHO ALL2008 Protocol</i>
Authors: Line Stensig Lynggaard, Lisbeth Moeller, Cecilie Utke Rank, Sofie Gottschalk Højfeldt, Louise Tram Henriksen, Kirsten Brunsvig Jarvis, Susanna Ranta, Riitta Niinimäki, Arja Harila-Saari, Benjamin Ole Wolthers, Mats Heyman, Thomas Leth Frandsen, Kjeld Schmiegelow, Birgitte Klug Albertsen
Journal: Blood (2020)
Compared to Normal-Weight Pregnant Women, Overweight Pregnant Women Fail to Upregulate Iron Absorption in the Third Trimester Despite Iron Deficiency and Their Infants Are Born with Lower Body Iron Stores
Authors: Nicole Ursula Stoffel, Michael Bruce Zimmermann, Ana Carla Cepeda Lopez, Karla I Cervantes Gracia, Elida E Lee Bazaldua, Zeder Christophe, Katharina Quack-Loetscher, Sueppong Gowachirapant, Isabelle Herter-Aeberli
Journal: Blood (2020)
Pediatric Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia Harboring Heterogeneous Genomic Profiles Respond to Venetoclax in Combination with Chemotherapy
Authors: Andrew E. Place, Seth E. Karol, Christopher J. Forlenza, Marion Gambart, Todd M. Cooper, Christopher Fraser, Gunnar Cario, Maureen M O'Brien, Nicolas U. Gerber, Phillip Barnette, Dirk Reinhardt, Giridharan Ramsingh, Bo Tong, Kristina Unnebrink, Deeksha Vishwamitra, Fengjiao Dunbar, Betty A. Prine, Tammy L. Palenski, Mignon L. Loh
Journal: Blood (2020)
A decision algorithm to promote outpatient antimicrobial stewardship for uncomplicated urinary tract infection
Authors: Sanjat Kanjilal, Michael Oberst, Sooraj Boominathan, Helen Zhou, David C. Hooper, David Sontag
Journal: Science Translational Medicine (2020)

Machine learning models for predicting antibiotic resistance could reduce the use of broad-spectrum antibiotics in urinary tract infection.