tbuckley/cabot-search huggingface dataset:
Glucose regulated protein GRP78 as a marker of recurrence in Adriamycin-treated breast cancer patients, a pilot study
Authors: Eunjung Lee, Darcy Spicer, Kambridge Hribar, Peter Nichols, Amy S. Lee, Mimi C. Yu
Journal: Cancer Research (2005)

4208  BACKGROUND: Resistance to chemotherapy is a major obstacle in treating breast cancer patients. One possible mechanism for drug resistance in breast cancer is the induction of the stress response. Strong in vitro data suggest that a specific class of glucose regulated proteins (GRPs), GRP78, is highly inducible in the hypoxic areas of the tumors and confers resistance to topoisomerase-targeting drugs. We investigated the association between GRP78 expression and chemoresistance in human breast cancer patients. METHODS: We obtained archived primary breast cancer specimens from 34 stage II and stage III breast cancer patients treated with Adriamycin, a topoisomerase II inhibitor, between 1992 and 1998. GRP78 expression level was measured by immunohistochemistry using commercially available antibodies against GRP78. GRP78 expression was determined based on percentage of positive staining cells and average intensity of staining. Logrank test and Kaplan-Meier method were used to analyze the association between GRP78 expression and time to tumor recurrence. RESULTS: Among the 34 stained specimens, 70.6% were positive for GRP78 expression. The estimated recurrence-free survival rates at the 5-year time point were 60% and 80% for GRP78 positive and negative groups, respectively. CONCLUSIONS: These pilot results suggest that the expression of stress protein GRP78 in human breast cancer is indicative of resistance to Adriamycin-based chemotherapy.
Electrohydrodynamic atomisation driven design and engineering of opportunistic particulate systems for applications in drug delivery, therapeutics and pharmaceutics
Authors: Amna Ali, Aliyah Zaman, Elshaimaa Sayed, David Evans, Stuart Morgan, Chris Samwell, John Hall, Muhammad Sohail Arshad, Neenu Singh, Omar Qutachi, Ming-Wei Chang, Zeeshan Ahmad
Journal: Advanced Drug Delivery Reviews (2021)
Progression of Aortic Stenosis and Long-term Follow-Up in Women
Authors: Ezra Amsterdam
Journal: Clinical Cardiology and Cardiovascular Interventions (2021)

Data on the rate of progression of aortic stenosis (AS) in women are limited. We retrospectively studied 95 female patients (age 75 ± 13 yrs) with aortic valve area (AVA) &lt;2.0 cm2 (mild AS 1.5-1.9 cm2, moderate AS 1.0-1.4 cm2, severe AS &lt;1.0 cm2). All patients underwent serial transthoracic echocardiography. We determined annual AVA decrease (rate of AS progression) by 3 approaches, each of which was applied to the entire cohort: 1) as a single group; 2) in the 3 subgroups of mild, moderate and severe AS; and 3) in the rapid and slower progressors. Study endpoints were aortic valve replacement (AVR) and all-cause mortality. The mean duration of follow-up was 4.5 ± 2.9 years. Mean rate of reduction in AVA for the total study group was 0.14 ± 0.16 cm2/yr and was directly related to presence of hypertension and baseline AVA, and inversely related to follow-up duration (all p&lt;0.05). The annualized decrease in AVA for each of the subgroups of mild, moderate and severe AS at baseline was 0.21±0.31 cm2, 0.13±0.11 cm2, 0.11±0.09 cm2, respectively (p&lt;0.0001). Rapid progression of AS (decrease in AVA ≥0.20 cm2/yr) occurred in 21% of patients (n=20) and was associated with baseline hypertension (p=0.03) and inversely related to follow-up duration (p=0.0007). Rapid progressors had shorter follow-up than slower progressors (20 vs. 42 mos, p=0.002). Event-free survival with end-points of death (n=65) or surgical/transcatheter AVR (n=24) at 1, 3, and 5 years, respectively, was 93%, 66% and 40% for mild AS; 96%, 72% and 48% for moderate AS; and 93%, 38% and 24% for severe AS. Thus, event-free survival at 5 years in patients with baseline severe AS was approximately half that of patients with AS of mild or moderate severity. In addition, event-free survival at 1 year in slower progressors was 92% and in rapid progressors was 70%.
Pediatric asthma incidence rates in the United States from 1980 to 2017
Authors: Christine C. Johnson, Suzanne L. Havstad, Dennis R. Ownby, Christine L.M. Joseph, Alexandra R. Sitarik, Jocelyn Biagini Myers, Tebeb Gebretsadik, Tina V. Hartert, Gurjit K. Khurana Hershey, Daniel J. Jackson, Robert F. Lemanske, Lisa J. Martin, Edward M. Zoratti, Cynthia M. Visness, Patrick H. Ryan, Diane R. Gold, Fernando D. Martinez, Rachel L. Miller, Christine M. Seroogy, Anne L. Wright, James E. Gern
Journal: Journal of Allergy and Clinical Immunology (2021)
TREATMENT PATTERNS AND OUTCOMES OF BIFURCATION LESIONS: FIRST RESULTS FROM THE PROSPECTIVE GLOBAL REGISTRY FOR THE STUDY OF BIFURCATION LESION INTERVENTIONS (PROGRESS-BIFURCATION)
Authors: Ilias Nikolakopoulos, Judit Karacsonyi, Evangelia Vemmou, Bavana Rangan, Raviteja Guddeti, Santiago Garcia, Konstantinos Tsioufis, Gerasimos Siasos, Dimitris Tousoulis, Mario Gossl, Ivan Chavez, Michael Mooney, Jay Traverse, Yale Wang, Anil Poulose, Paul Sorajja, M. Nicholas Burke, Emmanouil Brilakis
Journal: Journal of the American College of Cardiology (2021)
TB-QUICK: CRISPR-Cas12b-assisted rapid and sensitive detection of Mycobacterium tuberculosis
Authors: I Kuan Sam, Ying-ying Chen, Jun Ma, Shi-yuan Li, Ruo-yan Ying, Lin-xian Li, Ping Ji, Shu-jun Wang, Jie Xu, Yu-jie Bao, Guo-ping Zhao, Hua-jun Zheng, Jin Wang, Wei Sha, Ying Wang
Journal: Journal of Infection (2021)
A COMPREHENSIVE PROGRAM OF POST AMI CARE IMPROVES MEDICATION PRESCRIPTION UPON DISCHARGE
Authors: Michel Skaf, Wojciech Rzechorzek, Kirtipal Bhatia, Subrat Das, Claire Huang Lucas, Jan Lopes, Basera Sabharwal, Lingling Wu, Syed Ahsan, Jacqueline Tamis-Holland
Journal: Journal of the American College of Cardiology (2021)
CLINICAL CHARACTERISTICS AND OUTCOMES IN YOUNG ADULTS &lt; 45 YEARS OLD PRESENTING WITH ACUTE MYOCARDIAL INFARCTION STRATIFIED BY CORONARY ARTERY DISEASE BURDEN
Authors: Malini Nadadur, Sarah Chiu, Derek Phan, Karo Gyurjian, Bryant Hammershaimb, Yuh-Jer Shen, Ming-Sum Lee, Bryan Lin, Kaiser Permanente
Journal: Journal of the American College of Cardiology (2021)
AMR in low-resource settings: Médecins Sans Frontières bridges surveillance gaps by developing a turnkey solution, the Mini-Lab
Authors: Jean-Baptiste Ronat, Alessandra Natale, Thomas Kesteman, Antoine Andremont, Wael Elamin, Liselotte Hardy, Rupa Kanapathipillai, Justine Michel, Céline Langendorf, Olivier Vandenberg, Thierry Naas, Felix Kouassi
Journal: Clinical Microbiology and Infection (2021)

In low- and middle-income countries (LMICs), data related to antimicrobial resistance (AMR) are often inconsistently collected. Humanitarian, private and non-governmental medical organizations (NGOs), working with or in parallel to public medical systems, are sometimes present in these contexts. Yet, what is the role of NGOs in the fight against AMR, and how can they contribute to AMR data collection in contexts where reporting is scarce? How can context-adapted, high-quality clinical bacteriology be implemented in remote, challenging and underserved areas of the world?The aim was to provide an overview of AMR data collection challenges in LMICs and describe one initiative, the Mini-Lab project developed by Médecins Sans Frontières (MSF), that attempts to partially address them.We conducted a literature review using PubMed and Google scholar databases to identify peer-reviewed research and grey literature from publicly available reports and websites.We address the necessity of and difficulties related to obtaining AMR data in LMICs, as well as the role that actors outside of public medical systems can play in the collection of this information. We then describe how the Mini-Lab can provide simplified bacteriological diagnosis and AMR surveillance in challenging settings.NGOs are responsible for a large amount of healthcare provision in some very low-resourced contexts. As a result, they also have a role in AMR control, including bacteriological diagnosis and the collection of AMR-related data. Actors outside the public medical system can actively contribute to implementing and adapting clinical bacteriology in LMICs and can help improve AMR surveillance and data collection.
Continuing versus withdrawing ixekizumab treatment in patients with axial spondyloarthritis who achieved remission: efficacy and safety results from a placebo-controlled, randomised withdrawal study (COAST-Y)
Authors: Robert BM Landewé, Lianne S Gensler, Denis Poddubnyy, Proton Rahman, Maja Hojnik, Xiaoqi Li, Soyi Liu Leage, David Adams, Hilde Carlier, Filip Van den Bosch
Journal: Annals of the Rheumatic Diseases (2021)

Objectives The objective of COAST-Y was to evaluate the effect of continuing versus withdrawing ixekizumab (IXE) in patients with axial spondyloarthritis (axSpA) who had achieved remission. Methods COAST-Y is an ongoing, phase III, long-term extension study that included a double-blind, placebo (PBO)-controlled, randomised withdrawal-retreatment period (RWRP). Patients who completed the originating 52-week COAST-V, COAST-W or COAST-X studies entered a 24-week lead-in period and continued either 80 mg IXE every 2 (Q2W) or 4 weeks (Q4W). Patients who achieved remission (an Ankylosing Spondylitis Disease Activity Score (ASDAS)&lt;1.3 at least once at week 16 or week 20, and &lt;2.1 at both visits) were randomly assigned equally at week 24 to continue IXE Q4W, IXE Q2W or withdraw to PBO in a blinded fashion. The primary endpoint was the proportion of flare-free patients (flare: ASDAS≥2.1 at two consecutive visits or ASDAS&gt;3.5 at any visit) after the 40-week RWRP, with time-to-flare as a major secondary endpoint. Results Of 773 enrolled patients, 741 completed the 24-week lead-in period and 155 entered the RWRP. Forty weeks after randomised withdrawal, 83.3% of patients in the combined IXE (85/102, p&lt;0.001), IXE Q4W (40/48, p=0.003) and IXE Q2W (45/54, p=0.001) groups remained flare-free versus 54.7% in the PBO group (29/53). Continuing IXE significantly delayed time-to-flare versus PBO, with most patients remaining flare-free for up to 20 weeks after IXE withdrawal. Conclusions Patients with axSpA who continued treatment with IXE were significantly less likely to flare and had significantly delayed time-to-flare compared with patients who withdrew to PBO.
OUTCOME OF SPONTANEOUS CORONARY ARTERY DISSECTION IN CONGESTIVE HEART FAILURE PATIENTS
Authors: Adebayo Atanda, Olajide Buhari, Omowunmi Adedeji, Emily Newman, Shaitalya Vellanki, Tran Nguyen, Adeniyi Ajenifuja, Pedro Covas, Nardos Temesgen, Joseph Krepp, Gurusher Panjrath
Journal: Journal of the American College of Cardiology (2021)
Can Extensive Encircling Ipsilateral Pulmonary Vein Isolation Reduce the Onset of Stroke?: Long-term Follow-up Using CHADS2 Score Risk Stratification
Authors: Ohe Masatsugu, Gohya Masahiko, Hiroshima Kenichi, Hayashi Kentaro, Sonoda Koichiro, Iwabuchi Masashi, Yokoi Hiroyoshi, Nobuyoshi Masakiyo
Journal: Circulation (2010)
TEMPORAL TRENDS AND PREDICTORS OF SURGICAL ABLATION FOR ATRIAL FIBRILLATION IN A LARGE WESTERN US HEALTHCARE SYSTEM
Authors: Alison Leiataua, Scott C. Brancato, Mansen Wang, Kateri Spinelli, James Brevig, Zach DeBoard, Torin Fitton, Maheer Gandhavadi, Jonathan Piccini, Neil Worrall, Tyler Gluckman
Journal: Journal of the American College of Cardiology (2021)
Abstract 10747: Reflections on Health Behaviors and Suggestions for Future Health Promotion Programs From African American Women
Authors: Se Hee Min, Robin Whittemore, Holly Kennedy, Soohyun Nam
Journal: Circulation (2019)

Background: The purposes of this study were to explore: 1) middle-aged African-American (AA) women’s perception of their health behaviors from childhood to adulthood, 2) barriers to healthy lifesty...
Validation of the Who-Defined 20% Circulating Blasts Threshold for Diagnosis of Acute Leukemia in Myelofibrosis: A Single Center Study of 144 Patients with Blast or Chronic Phase Disease with Excess Blasts
Authors: Mythri Mudireddy, Curtis A. Hanson, Rhett P. Ketterling, Naseema Gangat, Animesh Pardanani, Ayalew Tefferi
Journal: Blood (2017)
SAFETY AND FEASIBILITY OF ROBOTIC ASSISTED PERCUTANEOUS CORONARY INTERVENTION COMPARED TO STANDARD PERCUTANEOUS CORONARY INTERVENTION- A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Purnima Sharma, Byomesh Tripathi, Sangeeta Bhat, Rohi Mishra, Smit Patel, Jason Klein, Saurav Kapadia, Divya Ratan Verma, Abhishek Deshmukh
Journal: Journal of the American College of Cardiology (2021)
Cancer-associated fibroblast-derived gene signatures determine prognosis in colon cancer patients
Authors: Mercedes Herrera, Alberto Berral-González, Igor López-Cade, Cristina Galindo-Pumariño, Santiago Bueno-Fortes, Manuel Martín-Merino, Alfredo Carrato, Alberto Ocaña, Carolina De La Pinta, Ana López-Alfonso, Cristina Peña, Vanesa García-Barberán, Javier De Las Rivas
Journal: Molecular Cancer (2021)
Lipid homeostasis and mevalonate pathway in COVID-19: Basic concepts and potential therapeutic targets
Authors: Maria Chiara Proto, Donatella Fiore, Chiara Piscopo, Cristina Pagano, Mario Galgani, Sara Bruzzaniti, Chiara Laezza, Patrizia Gazzerro, Maurizio Bifulco
Journal: Progress in Lipid Research (2021)
A NOVEL MOBILE APPLICATION TO DIAGNOSE AND TRANSFER PATIENTS WITH STEMI IN A LARGE HEALTHCARE SYSTEM: STEMICATHAID
Authors: Parasuram Melarcode Krishnamoorthy, Valentin Fuster, Andriy Vengrenyuk, Brian Wasielewski, Nitin Barman, Jeffrey Bander, Joseph Sweeny, Usman Baber, George Dangas, Umesh Gidwani, Georgios Syros, Manjit Singh, Yuliya Vengrenyuk, Ugo Ezenkwele, Jacqueline Tamis-Holland, Sudipto Srivastava, Kenny Chu, Abraham Warshaw, Atul Kukar, Matthew Bai, Bruce Darrow, Beth Oliver, Samin Sharma, Annapoorna Kini
Journal: Journal of the American College of Cardiology (2021)
INTRACORONARY AUTOLOGOUS CD34+ CELL THERAPY FOR TREATMENT OF CORONARY ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH ANGINA AND NON-OBSTRUCTIVE CORONARY ARTERIES: IMPROVE-CED TRIAL
Authors: Michel Corban, Takumi Toya, Diana Albers, Faten Sebaali, John Bois, Rajiv Gulati, Abhiram Prasad, Patricia Best, Malcolm Bell, Charanjit Rihal, Megha Prasad, Lilach Lerman, Mary L. Solseth, Jeffrey L. Winters, Allan B. Dietz, Amir Lerman
Journal: Journal of the American College of Cardiology (2021)
New Players in the Regulation of DNA-PK Activity: Survivin Joins the Crowd
Authors: George E. Iliakis
Journal: Cancer Research (2021)

Abstract The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a large protein kinase and a member of the PI3K-related family of protein kinases that also includes ATM and ATR. DNA-PKcs is a unique evolutionary endowment of higher eukaryotes, as it is absent in lower eukaryotes. It is central to the processing of DNA double-strand breaks by classical nonhomologous end-joining, where through interaction with the Ku70/Ku80 heterodimer it generates the DNA-PK holoenzyme. DNA-PK coordinates and regulates the joining of DNA ends through essential structural contributions and by direct phosphorylation of key repair factors, including itself. Recent structural studies advance our understanding of the functions of this giant enzyme and reveal functional complexity and sophistication compatible with a broad spectrum of activities. Along these lines, the observations reported in the article by Güllülü and colleagues in this issue of Cancer Research reveal intriguing new facets in the regulation of DNA-PKcs and open horizons for further exciting research. Güllülü and colleagues found that in addition to known modes of regulation, DNA-PKcs is also regulated by a direct interaction with survivin. The observations expand the functional and regulatory spectrum of this intriguing kinase and suggest contributions to DNA damage response that remain to be characterized. They formed the foundations for the development of drugs disrupting this interaction, thereby potentially sensitizing tumor cells to radiation. See related article by Güllülü et al., p. 2304
TRANSCATHETER AORTIC VALVE REPLACEMENT IN PATIENTS WITH UN-REVASCULARIZED LEFT MAIN DISEASE
Authors: Peter Evans, Robin Wang, Matthew Seigerman, David Jones, Jay Giri, Howard Herrmann, Taisei Kobayashi, Pavan Atluri, Wilson Szeto, Nimesh Desai, Robert Li, Paul Fiorilli
Journal: Journal of the American College of Cardiology (2021)
CaMKII Serine 280 O-GlcNAcylation Links Diabetic Hyperglycemia to Proarrhythmia
Authors: Bence Hegyi, Anna Fasoli, Christopher Y. Ko, Benjamin W. Van, Chidera C. Alim, Erin Y. Shen, Marisa M. Ciccozzi, Srinivas Tapa, Crystal M. Ripplinger, Jeffrey R. Erickson, Julie Bossuyt, Donald M. Bers
Journal: Circulation Research (2021)

Rationale: Diabetic hyperglycemia is associated with cardiac dysfunction and increased arrhythmia risk, and CaMKII (calcium/calmodulin-dependent protein kinase II) function has been implicated. CaMKII activity is promoted by both oxidation and O -linked β-N-acetylglucosamine ( O -GlcNAc) of known CaMKII sites. Objective: To investigate which posttranslational modifications occur in human diabetic hearts and how they alter electrophysiological and Ca 2+ handling properties in hyperglycemia. Methods and Results: We assessed echocardiography, electrophysiology, Ca 2+ -handling, and protein expression in site-specific CaMKII mutant mice ( O -GlcNAc-resistant S280A and oxidation-resistant MM281/2VV knock-ins, and global and cardiac-specific knockouts), in myocytes subjected to acute hyperglycemia and Ang II (angiotensin II) and mice after streptozotocin injections (to induce diabetes). Human patients with diabetes exhibit elevated CaMKII O -GlcNAcylation but not oxidation. In mice, acute hyperglycemia increased spontaneous diastolic Ca 2+ sparks and waves and arrhythmogenic action potential changes (prolongation, alternans, and delayed afterdepolarizations), all of which required CaMKII-S280 O -GlcNAcylation. Ang II effects were dependent on NOX2 (NADPH oxidase 2)-mediated CaMKII MM281/2 oxidation. Diabetes led to much greater Ca 2+ leak, RyR2 S2814 phosphorylation, electrophysiological remodeling, and increased susceptibility to in vivo arrhythmias, requiring CaMKII activation, predominantly via S280 O -GlcNAcylation and less via MM281/2 oxidation. These effects were present in myocytes at normal glucose but were exacerbated with the in vivo high circulating glucose. PLB (phospholamban) O -GlcNAcylation was increased and coincided with reduced PLB S16 phosphorylation in diabetes. Dantrolene, which reverses CaMKII-dependent proarrhythmic RyR-mediated Ca 2+ leak, also prevented hyperglycemia-induced APD prolongation and delayed afterdepolarizations. Conclusions: We found that CaMKII-S280 O -GlcNAcylation is required for increased arrhythmia susceptibility in diabetic hyperglycemia, which can be worsened by an additional Ang II-NOX2-CaMKII MM281/2 oxidation pathway. CaMKII-dependent RyR2 S2814 phosphorylation markedly increases proarrhythmic Ca 2+ leak and PLB O -GlcNAcylation may limit sarcoplasmic reticulum Ca 2+ reuptake, leading to impaired excitation-contraction coupling and arrhythmogenesis in diabetic hyperglycemia.
LEFT VENTRICULAR PSEUDOANEURYSM: A DECEPTIVE COMPLICATION POST TRANSAPICAL TRANSCATHETER AORTIC VALVE REPLACEMENT (TAVR)
Authors: Shilla Zachariah, Gabriel Areoye, Keerat Rai Ahuja, Charnjeet Sandhu, Oreoluwa Oladiran, Rishin Handa, Murtaza Sundhu, Muhammad Ameen, Anthony Licata
Journal: Journal of the American College of Cardiology (2021)
Management of Salivary Gland Malignancy: ASCO Guideline
Authors: Jessica L. Geiger, Nofisat Ismaila, Beth Beadle, Jimmy J. Caudell, Nicole Chau, Daniel Deschler, Christine Glastonbury, Marnie Kaufman, Eric Lamarre, Harold Y. Lau, Lisa Licitra, Michael G. Moore, Cristina Rodriguez, Anna Roshal, Raja Seethala, Paul Swiecicki, Patrick Ha
Journal: Journal of Clinical Oncology (2021)

PURPOSE To provide evidence-based recommendations for practicing physicians and other healthcare providers on the management of salivary gland malignancy. METHODS ASCO convened an Expert Panel of medical oncology, surgical oncology, radiation oncology, neuroradiology, pathology, and patient advocacy experts to conduct a literature search, which included systematic reviews, meta-analyses, randomized controlled trials, and prospective and retrospective comparative observational studies published from 2000 through 2020. Outcomes of interest included survival, diagnostic accuracy, disease recurrence, and quality of life. Expert Panel members used available evidence and informal consensus to develop evidence-based guideline recommendations. RESULTS The literature search identified 293 relevant studies to inform the evidence base for this guideline. Six main clinical questions were addressed, which included subquestions on preoperative evaluations, surgical diagnostic and therapeutic procedures, appropriate radiotherapy techniques, the role of systemic therapy, and follow-up evaluations. RECOMMENDATIONS When possible, evidence-based recommendations were developed to address the diagnosis and appropriate preoperative evaluations for patients with a salivary gland malignancy, therapeutic procedures, and appropriate treatment options in various salivary gland histologies. Additional information is available at www.asco.org/head-neck-cancer-guidelines .
INCIDENCE AND OUTCOMES OF PERICARDIAL EFFUSION/TAMPONADE FOLLOWING PERCUTANEOUS LEFT ATRIAL APPENDAGE CLOSURE
Authors: Toshiaki Isogai, Anas Saad, Shashank Shekhar, Abdelrahman Abushouk, Mohamed Gad, Samir Kapadia
Journal: Journal of the American College of Cardiology (2021)
Certain Aspects of Allergy in Children
Authors: Lewis Webb Hill
Journal: New England Journal of Medicine (1961)

THIS by no means purports to be a complete review of the recent literature concerning allergy in childhood. I have concentrated on a few broad subjects only, some of them highly controversial, that I consider of particular importance to pediatricians and general practitioners in their everyday work.Skin TestingAlthough skin tests are important in the specific diagnosis of allergic disease, according to Horesh,1 all competent allergists are agreed that the history is more important. The skin tests must corroborate the history to be of any value: without a detailed history they are worthless. Their value is dependent upon the . . .