tbuckley/cabot-search huggingface dataset:
Milrinone as Compared with Dobutamine in the Treatment of Cardiogenic Shock
Authors: Rebecca Mathew, Pietro Di Santo, Richard G. Jung, Jeffrey A. Marbach, Jordan Hutson, Trevor Simard, F. Daniel Ramirez, David T. Harnett, Anas Merdad, Aws Almufleh, Willy Weng, Omar Abdel-Razek, Shannon M. Fernando, Kwadwo Kyeremanteng, Jordan Bernick, George A. Wells, Vincent Chan, Michael Froeschl, Marino Labinaz, Michel R. Le May, Juan J. Russo, Benjamin Hibbert
Journal: New England Journal of Medicine (2021)

Cardiogenic shock is associated with substantial morbidity and mortality. Although inotropic support is a mainstay of medical therapy for cardiogenic shock, little evidence exists to guide the selection of inotropic agents in clinical practice.
3D Printing of Microgel Scaffolds with Tunable Void Fraction to Promote Cell Infiltration
Authors: Alexis J. Seymour, Sungchul Shin, Sarah C. Heilshorn
Journal: Advanced Healthcare Materials (2021)

Granular, microgel-based materials have garnered interest as promising tissue engineering scaffolds due to their inherent porosity, which can promote cell infiltration. Adapting these materials for 3D bioprinting, while maintaining sufficient void space to enable cell migration, can be challenging, since the rheological properties that determine printability are strongly influenced by microgel packing and void fraction. In this work, a strategy is proposed to decouple printability and void fraction by blending UV-crosslinkable gelatin methacryloyl (GelMA) microgels with sacrificial gelatin microgels to form composite inks. It is observed that inks with an apparent viscosity greater than ≈100 Pa s (corresponding to microgel concentrations ≥5 wt%) have rheological properties that enable extrusion-based printing of multilayered structures in air. By altering the ratio of GelMA to sacrificial gelatin microgels, while holding total concentration constant at 6 wt%, a family of GelMA:gelatin microgel inks is created that allows for tuning of void fraction from 0.20 to 0.57. Furthermore, human umbilical vein endothelial cells (HUVEC) seeded onto printed constructs are observed to migrate into granular inks in a void fraction-dependent manner. Thus, the family of microgel inks holds promise for use in 3D printing and tissue engineering applications that rely upon cell infiltration.
肝細胞核因子-6とノッチシグナル伝達の遺伝的相互作用は,マウスのIn Vivo肝内胆管発達を調節する
Authors: Vanderpool Charles, E Sparks Erin, A Huppert Kari, Gannon Maureen, L Means Anna, S Huppert Stacey
Journal: Hepatology (2012)
Neuroendocrine and Adrenal Tumors, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology
Authors: Manisha H. Shah, Whitney S. Goldner, Al B. Benson, Emily Bergsland, Lawrence S. Blaszkowsky, Pamela Brock, Jennifer Chan, Satya Das, Paxton V. Dickson, Paul Fanta, Thomas Giordano, Thorvardur R. Halfdanarson, Daniel Halperin, Jin He, Anthony Heaney, Martin J. Heslin, Fouad Kandeel, Arash Kardan, Sajid A. Khan, Boris W. Kuvshinoff, Christopher Lieu, Kimberly Miller, Venu G. Pillarisetty, Diane Reidy, Sarimar Agosto Salgado, Shagufta Shaheen, Heloisa P. Soares, Michael C. Soulen, Jonathan R. Strosberg, Craig R. Sussman, Nikolaos A. Trikalinos, Nataliya A. Uboha, Namrata Vijayvergia, Terence Wong, Beth Lynn, Cindy Hochstetler
Journal: Journal of the National Comprehensive Cancer Network (2021)

The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Neuroendocrine and Adrenal Gland Tumors focus on the diagnosis, treatment, and management of patients with neuroendocrine tumors (NETs), adrenal tumors, pheochromocytomas, paragangliomas, and multiple endocrine neoplasia. NETs are generally subclassified by site of origin, stage, and histologic characteristics. Appropriate diagnosis and treatment of NETs often involves collaboration between specialists in multiple disciplines, using specific biochemical, radiologic, and surgical methods. Specialists include pathologists, endocrinologists, radiologists (including nuclear medicine specialists), and medical, radiation, and surgical oncologists. These guidelines discuss the diagnosis and management of both sporadic and hereditary neuroendocrine and adrenal tumors and are intended to assist with clinical decision-making. This article is focused on the 2021 NCCN Guidelines principles of genetic risk assessment and counseling and recommendations for well-differentiated grade 3 NETs, poorly differentiated neuroendocrine carcinomas, adrenal tumors, pheochromocytomas, and paragangliomas.
Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study
Authors: David Hillus, Tatjana Schwarz, Pinkus Tober-Lau, Kanika Vanshylla, Hana Hastor, Charlotte Thibeault, Stefanie Jentzsch, Elisa T Helbig, Lena J Lippert, Patricia Tscheak, Marie Luisa Schmidt, Johanna Riege, André Solarek, Christof von Kalle, Chantip Dang-Heine, Henning Gruell, Piotr Kopankiewicz, Norbert Suttorp, Christian Drosten, Harald Bias, Joachim Seybold, Ben Al-Rim, Lara Bardtke, Jörn Ilmo Beheim-Schwarzbach, Kerstin Behn, Leon Bergfeld, Norma Bethke, Tobias Bleicker, Dana Briesemeister, Sophia Brumhard, Claudia Conrad, Sebastian Dieckmann, Doris Frey, Julie-Anne Gabelich, Philipp Georg, Ute Gläser, Lisbeth Hasler, Andreas Hetey, Anna Luisa Hiller, Alexandra Horn, Claudia Hülso, Luisa Kegel, Willi Koch, Alexander Krannich, Paolo Kroneberg, Michelle Lisy, Petra Mackeldanz, Birgit Maeß, Friederike Münn, Nadine Olk, Christian Peiser, Kai Pohl, Annelie Hermel, Maria Rönnefarth, Carolin Rubisch, Angela Sanchez Rezza, Isabelle Schellenberger, Viktoria Schenkel, Jenny Schlesinger, Sein Schmidt, Georg Schwanitz, Anne-Sophie Sinnigen, Paula Stubbemann, Julia Tesch, Denise Treue, Daniel Wendisch, Saskia Zvorc, Florian Klein, Florian Kurth, Victor Max Corman, Leif Erik Sander
Journal: The Lancet Respiratory Medicine (2021)
Change to Helping Patients With Symptomatic Cholelithiasis—Does Everybody Win With an Operation?
Authors: Courtney Collins, Benjamin K. Poulose
Journal: JAMA Surgery (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Association of Chlamydia and Mycoplasma infections with susceptibility to ovarian cancer: A systematic review and meta-analysis
Authors: Seyed-Abolfazl Hosseininasab-Nodoushan, Kiarash Ghazvini, Tannaz Jamialahmadi, Masoud Keikha, Amirhossein Sahebkar
Journal: Seminars in Cancer Biology (2021)
Durable Treatment of Refractory Vesicourethral Anastomotic Stenosis via Robotic-assisted Reconstruction: A Trauma and Urologic Reconstructive Network of Surgeons Study
Authors: Nabeel A. Shakir, Nejd F. Alsikafi, Julia F. Buesser, Gregory Amend, Benjamin N. Breyer, Jill C. Buckley, Bradley A. Erickson, Joshua A. Broghammer, William P. Parker, Lee C. Zhao
Journal: European Urology (2021)
lncRNA ITGB8-AS1 functions as a ceRNA to promote colorectal cancer growth and migration through integrin-mediated focal adhesion signaling
Authors: Xiaoting Lin, Shiwen Zhuang, Xue Chen, Jun Du, Longhua Zhong, Jiancheng Ding, Lei Wang, Jia Yi, Guosheng Hu, Guohui Tang, Xi Luo, Wen Liu, Feng Ye
Journal: Molecular Therapy (2021)

Long non-coding RNAs (lncRNAs) play critical roles in tumorigenesis and progression of colorectal cancer (CRC). However, functions of most lncRNAs in CRC and their molecular mechanisms remain uncharacterized. Here we found that lncRNA ITGB8-AS1 was highly expressed in CRC. Knockdown of ITGB8-AS1 suppressed cell proliferation, colony formation, and tumor growth in CRC, suggesting oncogenic roles of ITGB8-AS1. Transcriptomic analysis followed by KEGG analysis revealed that focal adhesion signaling was the most significantly enriched pathway for genes positively regulated by ITGB8-AS1. Consistently, knockdown of ITGB8-AS1 attenuated the phosphorylation of SRC, ERK, and p38 MAPK. Mechanistically, ITGB8-AS1 could sponge miR-33b-5p and let-7c-5p/let-7d-5p to regulate the expression of integrin family genes ITGA3 and ITGB3, respectively, in the cytosol of cells. Targeting ITGB8-AS1 using antisense oligonucleotide (ASO) markedly reduced cell proliferation and tumor growth in CRC, indicating the therapeutic potential of ITGB8-AS1 in CRC. Furthermore, ITGB8-AS1 was easily detected in plasma of CRC patients, which was positively correlated with differentiation and TNM stage, as well as plasma levels of ITGA3 and ITGB3. In conclusion, ITGB8-AS1 functions as a competing endogenous RNA (ceRNA) to regulate cell proliferation and tumor growth of CRC via regulating focal adhesion signaling. Targeting ITGB8-AS1 is effective in suppressing CRC cell growth and tumor growth. Elevated plasma levels of ITGB8-AS1 were detected in advanced-stage CRC. Thus, ITGB8-AS1 could serve as a potential therapeutic target and circulating biomarker in CRC.
Enhancing Recruitment and Retention of Minority Populations for Clinical Research in Pulmonary, Critical Care, and Sleep Medicine: An Official American Thoracic Society Research Statement
Authors: Neeta Thakur, Stephanie Lovinsky-Desir, Donna Appell, Christian Bime, Lauren Castro, Juan C. Celedón, Juliana Ferreira, Maureen George, Yolanda Mageto, Arch G. Mainous, Smita Pakhale, Kristin A. Riekert, Jesse Roman, Elizabeth Ruvalcaba, Sunil Sharma, Priya Shete, Juan P. Wisnivesky, Fernando Holguin
Journal: American Journal of Respiratory and Critical Care Medicine (2021)

Background: Well-designed clinical research needs to obtain information that is applicable to the general population. However, most current studies fail to include substantial cohorts of racial/ethnic minority populations. Such underrepresentation may lead to delayed diagnosis or misdiagnosis of disease, wide application of approved interventions without appropriate knowledge of their usefulness in certain populations, and development of recommendations that are not broadly applicable.Goals: To develop best practices for recruitment and retention of racial/ethnic minorities for clinical research in pulmonary, critical care, and sleep medicine.Methods: The American Thoracic Society convened a workshop in May of 2019. This included an international interprofessional group from academia, industry, the NIH, and the U.S. Food and Drug Administration, with expertise ranging from clinical and biomedical research to community-based participatory research methods and patient advocacy. Workshop participants addressed historical and current mistrust of scientific research, systemic bias, and social and structural barriers to minority participation in clinical research. A literature search of PubMed and Google Scholar was performed to support conclusions. The search was not a systematic review of the literature.Results: Barriers at the individual, interpersonal, institutional, and federal/policy levels were identified as limiting to minority participation in clinical research. Through the use of a multilevel framework, workshop participants proposed evidence-based solutions to the identified barriers.Conclusions: To date, minority participation in clinical research is not representative of the U.S. and global populations. This American Thoracic Society research statement identifies potential evidence-based solutions by applying a multilevel framework that is anchored in community engagement methods and patient advocacy.
Neuromechanobiology: An Expanding Field Driven by the Force of Greater Focus
Authors: Cara T. Motz, Victoria Kabat, Tarun Saxena, Ravi V. Bellamkonda, Cheng Zhu
Journal: Advanced Healthcare Materials (2021)

The brain processes information by transmitting signals through highly connected and dynamic networks of neurons. Neurons use specific cellular structures, including axons, dendrites and synapses, and specific molecules, including cell adhesion molecules, ion channels and chemical receptors to form, maintain and communicate among cells in the networks. These cellular and molecular processes take place in environments rich of mechanical cues, thus offering ample opportunities for mechanical regulation of neural development and function. Recent studies have suggested the importance of mechanical cues and their potential regulatory roles in the development and maintenance of these neuronal structures. Also suggested are the importance of mechanical cues and their potential regulatory roles in the interaction and function of molecules mediating the interneuronal communications. In this review, the current understanding is integrated and promising future directions of neuromechanobiology are suggested at the cellular and molecular levels. Several neuronal processes where mechanics likely plays a role are examined and how forces affect ligand binding, conformational change, and signal induction of molecules key to these neuronal processes are indicated, especially at the synapse. The disease relevance of neuromechanobiology as well as therapies and engineering solutions to neurological disorders stemmed from this emergent field of study are also discussed.
Assuring long-term safety of highly effective gene-modulating therapeutics for rare diseases
Authors: Thomas O. Crawford, Charlotte J. Sumner
Journal: Journal of Clinical Investigation (2021)

A recent demonstration by Van Alstyne and colleagues (1) of long-term toxicity following short-term successful treatment of an animal model of spinal muscular atrophy (SMA) by gene transfer-mediated overexpression of survival motor neuron (SMN) protein raises immediate questions for SMA patients, their families, and advising clinicians.This finding, however, also highlights the limits of safety data associated with any new therapy validated in small clinical trials of a rare disease as well as the potential inadequacy of current procedures for assuring long-term safety in gene-therapy programs under development.Optimal assessment of the safety of rare disease therapies may require improvements at multiple levels of the drug development, regulatory review, and postapproval monitoring processes.
Effects of Exercise and Weight Loss on Proximal Aortic Stiffness in Older Adults With Obesity
Authors: Tina E. Brinkley, Iris Leng, Margie J. Bailey, Denise K. Houston, Christina E. Hugenschmidt, Barbara J. Nicklas, W. Gregory Hundley
Journal: Circulation (2021)

Background: Obesity may accelerate age-related increases in aortic stiffness. Although aerobic exercise training generally has favorable effects on aortic structure and function, exercise alone may not be sufficient to improve aortic stiffness in older adults with obesity. We determined the effects of aerobic exercise training with and without moderate- to high-caloric restriction (CR) on the structure and function of the proximal aorta in 160 older (65–79 years) men and women with obesity (body mass index=30–45 kg/m 2 ). Methods: Participants were randomly assigned to 1 of 3 groups: aerobic exercise training only (treadmill 4 days/week for 30 minutes at 65% to 70% of heart rate reserve; n=56), aerobic exercise training plus moderate CR (n=55), or aerobic exercise training plus more intensive CR (n=49) for 20 weeks. Aortic pulse wave velocity, aortic distensibility, and other measures of aortic structure and function were assessed by cardiovascular magnetic resonance imaging. Pearson correlation coefficients were examined to assess associations between changes in proximal aortic stiffness and changes in fitness, fatness, and other potential confounders. Results: Weight loss in the aerobic exercise training plus moderate CR (−8.0 kg [95% CI, −9.17 to −6.87]) and aerobic exercise training plus more intensive CR (−8.98 kg [95% CI, −10.23 to −7.73) groups was significantly greater compared with the aerobic exercise training–only group (−1.66 kg [95% CI, −2.94 to −0.38]; P &lt;0.017 for both). There were significant treatment effects for descending aorta distensibility ( P =0.008) and strain ( P =0.004) and aortic arch pulse wave velocity ( P =0.01) with the aerobic exercise training plus moderate CR group having a 21% increase in distensibility ( P =0.016) and an 8% decrease in pulse wave velocity ( P =0.058). None of the aortic stiffness measures changed significantly in the aerobic exercise training–only or aerobic exercise training plus more intensive CR groups, and there were no significant changes in any other measure of aortic structure or function in these groups. Overall, increases in aortic distensibility were correlated with improvements in body weight and body fat distribution, but these associations were not statistically significant after adjustment for multiple comparisons. Conclusions: In older adults with obesity, combining aerobic exercise with moderate CR leads to greater improvements in proximal aortic stiffness than exercise alone. Registration: URL: https://clinicaltrials.gov ; Unique identifier: NCT01048736.
COVID-19 case-clusters and transmission chains in the communities in Japan
Authors: Yuki Furuse, Naho Tsuchiya, Reiko Miyahara, Ikkoh Yasuda, Eiichiro Sando, Yura K Ko, Takeaki Imamura, Konosuke Morimoto, Tadatsugu Imamura, Yugo Shobugawa, Shohei Nagata, Atsuna Tokumoto, Kazuaki Jindai, Motoi Suzuki, Hitoshi Oshitani
Journal: Journal of Infection (2021)
Association between sepsis survivorship and long-term cardiovascular outcomes in adults: a systematic review and meta-analysis
Authors: Leah B. Kosyakovsky, Federico Angriman, Emma Katz, Neill K. Adhikari, Lucas C. Godoy, John C. Marshall, Bruno L. Ferreyro, Douglas S. Lee, Robert S. Rosenson, Naveed Sattar, Subodh Verma, Augustin Toma, Marina Englesakis, Barry Burstein, Michael E. Farkouh, Margaret Herridge, Dennis T. Ko, Damon C. Scales, Michael E. Detsky, Lior Bibas, Patrick R. Lawler
Journal: Intensive Care Medicine (2021)
Abusive Head Trauma and Infant Crying—A Flawed Analysis
Authors: John M. Leventhal, George A. Edwards, Ronald G. Barr
Journal: JAMA Pediatrics (2021)

To the Editor The Viewpoint by Lynøe and Eriksson1 about abusive head trauma (AHT) is seriously flawed. The argument that crying does not trigger AHT is based on twisted logic, unsupported assertions, and misrepresented data.
FDA Approval Summary: Capmatinib and Tepotinib for the Treatment of Metastatic NSCLC Harboring MET Exon 14 Skipping Mutations or Alterations
Authors: Luckson N. Mathieu, Erin Larkins, Oladimeji Akinboro, Pourab Roy, Anup K. Amatya, Mallorie H. Fiero, Pallavi S. Mishra-Kalyani, Whitney S. Helms, Claire E. Myers, Amy M. Skinner, Stephanie Aungst, Runyan Jin, Hong Zhao, Huiming Xia, Jeanne Fourie Zirkelbach, Youwei Bi, Yangbing Li, Jiang Liu, Manuela Grimstein, Xinyuan Zhang, Stacie Woods, Kelie Reece, Abdelrahmman M. Abukhdeir, Soma Ghosh, Reena Philip, Shenghui Tang, Kirsten B. Goldberg, Richard Pazdur, Julia A. Beaver, Harpreet Singh
Journal: Clinical Cancer Research (2021)

The FDA approved capmatinib and tepotinib on May 6, 2020, and February 3, 2021, respectively. Capmatinib is indicated for patients with metastatic non-small cell lung cancer (mNSCLC) whose tumors have a mutation leading to mesenchymal-epithelial transition (MET) exon 14 skipping as detected by an FDA-approved test. Tepotinib is indicated for mNSCLC harboring MET exon 14 skipping alterations. The approvals were based on trials GEOMETRY mono-1 (capmatinib) and VISION (tepotinib). In GEOMETRY mono-1, overall response rate (ORR) per Blinded Independent Review Committee (BIRC) was 68% [95% confidence interval (CI), 48-84] with median duration of response (DoR) 12.6 months (95% CI, 5.5-25.3) in 28 treatment-naïve patients and 41% (95% CI: 29, 53) with median DoR 9.7 months (95% CI, 5.5-13) in 69 previously treated patients with NSCLC with mutations leading to MET exon 14 skipping. In VISION, ORR per BIRC was 43% (95% CI: 32, 56) with median DoR 10.8 months (95% CI, 6.9-not estimable) in 69 treatment-naïve patients and 43% (95% CI, 33-55) with median DoR 11.1 months (95% CI, 9.5-18.5) in 83 previously-treated patients with NSCLC harboring MET exon 14 alterations. These are the first two therapies to be FDA approved specifically for patients with metastatic NSCLC with MET exon 14 skipping.
P-125 Caring for more than survival: A survey of patient preferences in advanced hepatocellular carcinoma
Authors: R. Sharma, S. Lo, D. Aggio, F. Colaone, I. Agirrezabal, V. Straccia, V. Brennan, S. Shergill, A. Lloyd, C. Costentin
Journal: Annals of Oncology (2021)
YAP‐TEAD mediates PPAR α–induced hepatomegaly and liver regeneration in mice
Authors: Shicheng Fan, Yue Gao, Aijuan Qu, Yiming Jiang, Hua Li, Guomin Xie, Xinpeng Yao, Xiao Yang, Shuguang Zhu, Tomoki Yagai, Jianing Tian, Ruimin Wang, Frank J. Gonzalez, Min Huang, Huichang Bi
Journal: Hepatology (2021)

Peroxisome proliferator-activated receptor α (PPARα, NR1C1) is a ligand-activated nuclear receptor involved in the regulation of lipid catabolism and energy homeostasis. PPARα activation induces hepatomegaly and plays an important role in liver regeneration, but the underlying mechanisms remain unclear.In this study, the effect of PPARα activation on liver enlargement and regeneration was investigated in several strains of genetically modified mice. PPARα activation by the specific agonist WY-14643 significantly induced hepatomegaly and accelerated liver regeneration after 70% partial hepatectomy (PHx) in wild-type mice and Pparafl/fl mice, while these effects were abolished in hepatocyte-specific Ppara-deficient (PparaΔHep ) mice. Moreover, PPARα activation promoted hepatocyte hypertrophy around the central vein area and hepatocyte proliferation around the portal vein area. Mechanistically, PPARα activation regulated expression of yes-associated protein (YAP) and its downstream targets (connective tissue growth factor, cysteine-rich angiogenic inducer 61, and ankyrin repeat domain 1) as well as proliferation-related proteins (cyclins A1, D1, and E1). Binding of YAP with the PPARα E domain was critical for the interaction between YAP and PPARα. PPARα activation further induced nuclear translocation of YAP. Disruption of the YAP-transcriptional enhancer factor domain family member (TEAD) association significantly suppressed PPARα-induced hepatomegaly and hepatocyte enlargement and proliferation. In addition, PPARα failed to induce hepatomegaly in adeno-associated virus-Yap short hairpin RNA-treated mice and liver-specific Yap-deficient mice. Blockade of YAP signaling abolished PPARα-induced hepatocyte hypertrophy around the central vein area and hepatocyte proliferation around the portal vein area.This study revealed a function of PPARα in regulating liver size and liver regeneration through activation of the YAP-TEAD signaling pathway. These findings have implications for understanding the physiological functions of PPARα and suggest its potential for manipulation of liver size and liver regeneration.
1999~2006年の結腸直腸癌,乳癌,および肺癌患者における病院診療の利用の社会的差異:病院エピソード統計量のレトロスペクティブ分析
Authors: Raine Rosalind, Wong Wun, Scholes Shaun, Ashton Charlotte, Obichere Austin, Ambler Gareth
Journal: BMJ (2010)