tbuckley/cabot-search huggingface dataset:
Royal malady.
Authors: I. Macalpine, R. Hunter, C. Rimington
Journal: BMJ (1968)

MEDBIJO 705 if the subject has an intercurrent infection or has taken alcohol or other drugs.Prolonged unconsciousness also results from taking mixtures of tranquillizers and hypnotic drugs when alcohol or dexamphetamine or barbiturates are ingredients.I agree with Dr. H. J. S. Matthew (10 February, p. 380) that the evidence is extremely confusing.It would be interesting to know if people who have given L.S.D.-25 therapeutically have ever encountered prolonged coma.The first case of chronic psychosis following therapeutic L.S.D.-25 which I ever saw was a man who later died of leukaemia.This has given me much food for thought in the light of the present research on chromosomal aberrations after L.S.D.-25, and might be worth pursuing.I am, etc., London W.2.
Jackson Lab Receives New KOMP2 Grant
Journal: Cancer Discovery (2016)

The Jackson Laboratory has been awarded $28.3 million from the NIH to expand the Knockout Mouse Production and Phenotyping Project, which was launched in 2011. Since then, researchers there have made and extensively phenotyped 833 knockout mouse strains from embryonic stem cells. Now, they'll capitalize on CRISPR/Cas9 technology to generate another 1,000 strains in the next 5 years.
Diet and Personality: Fitting Food to Type and Environment
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Darolutamide and Survival in Metastatic, Hormone-Sensitive Prostate Cancer
Authors: Matthew R. Smith, Maha Hussain, Fred Saad, Karim Fizazi, Cora N. Sternberg, E. David Crawford, Evgeny Kopyltsov, Chandler H. Park, Boris Alekseev, Álvaro Montesa-Pino, Dingwei Ye, Francis Parnis, Felipe Cruz, Teuvo L.J. Tammela, Hiroyoshi Suzuki, Tapio Utriainen, Cheng Fu, Motohide Uemura, María J. Méndez-Vidal, Benjamin L. Maughan, Heikki Joensuu, Silke Thiele, Rui Li, Iris Kuss, Bertrand Tombal
Journal: New England Journal of Medicine (2022)

Darolutamide is a potent androgen-receptor inhibitor that has been associated with increased overall survival among patients with nonmetastatic, castration-resistant prostate cancer. Whether a combination of darolutamide, androgen-deprivation therapy, and docetaxel would increase survival among patients with metastatic, hormone-sensitive prostate cancer is unknown.
Questions and Answers
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chloroform Deaths
Authors: W. F. Morgan
Journal: BMJ (1872)

58Icele.In spite, however, of the success in this instance, I am not in- clined to tlinlk that the plan wvould prove generally efficacious in the treatment of even recent hacmatocele, and I do not now at all desire to advocate it in such cases.In regard, however, to hydrocele, it appears to me that we have in this plan of tapping and strapping one which satisfactorily fulfils the idea of curing safely, quickly, and pleasantly, and which, though per- haps not about to prove infallible, is one which should be certainly tried in all cases (especially, I would add, those treated away from the patient's home), before the injection of iodine or other stimulant is re- sorted to.If cases occur in which neither the mode I here advocate nor the iodine treatment is successful, I am of opinion that a combination of the two would be likely to prove so.
Transplantation
Authors: Mark A. Hardy
Journal: JAMA (1993)

Many advances in clinical and experimental transplantation have occurred in recent years. Significant progress has been made to solve the universal problems of donor organ shortages and the dependency of recipients on chronic immunosuppression. Pioneering efforts in small-bowel and islet cell transplantation are of particular interest because of their potential impact on patient care and the field of transplantation. Donor shortages lengthen waiting lists for all organs worldwide. The waiting time for a cadaveric renal transplant may be over 500 days.<sup>1</sup>The mortality rate for children with end-stage chronic liver disease who are awaiting transplantation is nearly 25%.<sup>2</sup>There are several means currently used to shorten waiting lists, with others currently under experimental consideration. First of all, living unrelated donors may be used for kidney transplantation. It is accepted that living unrelated renal transplantation (LURTx) is ethically permissible if no suitable kidney transplant is available from a cadaveric
Measles Meningoencephalomyelitis
Authors: W. F. T. McMath
Journal: BMJ (1954)

Accounts of nervous disorders associated with measles, some of which were presumably meningoencephalitis, can be traced as far back as the beginning of the eighteenth century, according to the historians Comby (1935) and Rolleston (1937).In this series 10 cases were encountered over a short period-three in the second quarter of 1951, from the Borough of Wembley, and seven between September, 1951, and June, 1953, widely distributed in the boroughs surrounding Neasden Hospital, a further two being from Wembley.The well-known protean character of the disease, and its tendency to occur in little groups, were well illustrated by these cases, but no light was thrown on the pathogenesis of the condition or on prevention and treatment, apart from the failure of A.C.T.H. to influence its course.Notes of 10 Cases In Present Series Case 1.-Female, 3+ years; severe measles.Severe encephalitis 5 days after rash; delirium, choreiform move- ments progressing over 10 days, coma 20 days.Retention of urine and incontinence of faeces.Flaccid quadriplegia.Plantar reflexes extensor and squint.Meningeal signs nega- tive.C.S.F.normal.Complete recovery from
VITAMINES
Authors: W. D. Halliburton
Journal: BMJ (1919)

IB 4 583or only a refiexion of improved skill in diagnosis.The latter hypothesis was supported by the analysis of Frank- fort data made in 1893 by King and-Newsholme, and has since been discussed by numerous statisticians, including Hoffman and Willcox in America, Parkes, Greenwood, and Wood in England, Prinzing in Germany.Willcox has brought the Frankfort statistics used by Newsholme and King down to 1913, and the more recent data support the inference of the last-named authors as to the share of the increase borne by cancer of inaccessible sites for which improvement of diagnosis might be responsible.But the analysis provided by.Dr. Stevenson of the -much more num-ierous English data points to a very different conclusion.Taking the longer interval of nineteen years, 1897-98 to 1916X47, the growth df mortality from accessible calicere has been 56 per cent.amongstrmtles, as against an intwease of only 41 per-cent.from inaccessible.This remarkable and quite unex- pected result makes it verry difficult to attribute so important a share in the recorded increase in the cancer of males to improved diagnosis as has hitherto seemed probable.It appears to us that Dr. Stevenson's analysis almost amounts to a demonstration that a real increase of cancer hits taken place, and such we should judge to be his, own opinion, although objections and possible sources of fallacy are displayed with the 'scientiflc candour which we have long learned to expect in the publications of the R1egistrar- General's department.'The deaths attributable to alcoholism have decreased.Upon this Dr.Stevenson writes:It is-impossible to avoid associating this sudden drop in mor- tality -with the restrictions in the output of alcoholic liquors and of public-house hours brought about by the war, but it is advisable to bear in mind that many other changes have opcurred since 1914, some of which might have a bearing upon tll matter.The deaths allocated to cerebro-spinal fever numbered 1,531 in 1917, as against 1,214 in 1916 and 1,974 in 1915.The highest numbers previously recorded were 194 in 1914 and 163 in 1913.Altogether 39,832 persons died of some form of pneu- monia.Outside of London, mortality decreased generally from North to South and the mortality also decreased with decreasing urbanization (being 1,400 per million for London, 1,358 for countyrboroughs, 1,017 for other urban districts, and 843 for vural districts).Both featurEs are so regular from year to' year that they may be 'accepted as defining the habitual" type of distribution in this country.
Violations of code of marketing breast milk substitutes are common
Journal: BMJ (1998)

Violations of code of marketing breast milk substitutes are commonThe international code of marketing of substitutes for breast milk was adopted by the World Health Assembly in 1981 to encourage mothers to breast feed and to ensure that women make informed choices when deciding how to feed their babies.On p 1117 Taylor reports the results of a study investigating violations of the code in four countries.Despite their stated support for the code, manufacturers of breast milk substitutes continue to provide free samples of substitutes, bottles, and teats to health professionals.Health facilities play an important part in distributing these samples to pregnant women and mothers of infants.There is an urgent need for implementation and monitoring of the code nationally; the study protocol used to investigate these issues could be applied easily to other countries.
Detection and characterization of low-level mosaicism among clinically unaffected parents of ‘sporadic’ epidermolysis bullosa simplex cases
Authors: Fuying Chen, Dan Deng, Chaolan Pan, Zhirong Yao, Yan Gu, Ming Li
Journal: British Journal of Dermatology (2022)

In this study, two (18.2%) clinically unaffected parents from 11 trios were identified with mosaic KRT14 variants.To our knowledge, this is the first report to study the proportion of low-level mosaicism in the clinically unaffected parents whose children were previously regarded as sporadic EBS cases.
Inhibition of LDHA to induce eEF2 release enhances thrombocytopoiesis
Authors: Qidi Chen, Min Xin, Lingjun Wang, Lin Li, Yingzhi Shen, Yan Geng, Haojie Jiang, Yang Wang, Lin Zhang, Yanyan Xu, Yu Hou, Junling Liu, Xuemei Fan
Journal: Blood (2022)
Overall survival (OS) after progression on first novel hormonal therapy (NHT) in patients (pts) with metastatic castration-sensitive versus castration-resistant prostate cancer (mCSPC versus mCRPC).
Authors: Nicolas Sayegh, Nishita Tripathi, Taylor Ryan McFarland, Adam Kessel, Roberto Nussenzveig, Beverly Chigarira, Haoran Li, Clara Tandar, Divyam Goel, Blake Nordblad, Jackson Cheney, Kamal Kant Sahu, Benjamin L. Maughan, Umang Swami, Neeraj Agarwal
Journal: Journal of Clinical Oncology (2022)

121 Background: Novel hormonal therapy (NHT) i.e. novel androgen receptor or androgen synthesis inhibitors have been approved for treatment of pts with mCSPC and mCRPC based on improved OS. However, OS of patients after progression on first-line NHT for mCSPC is not well characterized. It is currently unknown whether the OS in pts “after” progression on first-line NHT in mCSPC versus mCRPC is significantly different. Herein, our objective was to assess OS after disease progression on NHT given as the first-line therapy in the mCSPC vs first-line therapy in mCRPC setting. Methods: In this IRB-approved study, patient-level data were collected retrospectively, only those treated with NHT as first-line therapy for mCSPC or mCRPC were included. For patients receiving NHT in the mCRPC setting, no prior NHT was allowed in the mCSPC setting. Median overall survival and hazard ratios were determined by Kaplan-Meier analysis. Results: A total of 173 pts (45 mCSPC and 128 mCRPC) were eligible and included in the analysis. Median OS in the mCSPC versus mCRPC were similar: 23 vs. 17 months, hazard ratio: 0.9855, (95% CI: 0.6225 – 1.560, P=0.951). See the table. Conclusions: These results suggest median OS is similar after progression on one NHT whether given in the first-line mCSPC or first-line mCRPC setting. These data have implications on patient counseling and prognostication as well as the design of clinical trials in patients experiencing disease progression on an NHT. These hypothesis generating data need external validation.[Table: see text]
THE ACID EXCRETING FUNCTION OF THE KIDNEY
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ueber die Agraphie und ihre lokaldiagnostischen Beziehungen.
Journal: JAMA (1926)

As the basis for this work the authors outline a case in which the earliest and most prominent symptom was agraphia associated later with alexia, left hemianopia, disturbances in showing and naming the fingers of the left hand, left hemiparesis, and disturbances in tactile localization on the left side. The focal diagnosis, confirmed exactly at operation and later at necropsy, placed the lesion at the junction of the angular gyrus with the second occipital convolution. The tumor, though malignant in character, was shelled out without difficulty, and the patient improved greatly for a time. The evolution and disappearance of the symptoms lead to the view that agraphia is an individual disturbance of great localizing value and the relations with apraxia, word-blindness and other forms of aphasic disorder are discussed. The book contains an admirable review of the recorded cases and includes the report of a second case observed by the
The potential of fecal microbiota and amino acids to detect and monitor patients with adenoma
Authors: Sofie Bosch, Animesh Acharjee, Mohammed N Quraishi, Patricia Rojas, Abdellatif Bakkali, Erwin EW Jansen, Marina Brizzio Brentar, Johan Kuijvenhoven, Pieter Stokkers, Eduard Struys, Andrew D Beggs, Georgios V Gkoutos, Tim GJ de Meij, Nanne KH de Boer
Journal: Gut Microbes (2022)

The risk of recurrent dysplastic colonic lesions is increased following polypectomy. Yield of endoscopic surveillance after adenoma removal is low, while interval colorectal cancers occur. To longitudinally assess the dynamics of fecal microbiota and amino acids in the presence of adenomatous lesions and after their endoscopic removal. In this longitudinal case–control study, patients collected fecal samples prior to bowel preparation before scheduled colonoscopy and 3 months after this intervention. Based on colonoscopy outcomes, patients with advanced adenomas and nonadvanced adenomas (0.5–1.0 cm) who underwent polypectomy during endoscopy (n = 19) were strictly matched on age, body-mass index, and smoking habits to controls without endoscopic abnormalities (n = 19). Microbial taxa were measured by 16S RNA sequencing, and amino acids (AA) were measured by high-performance liquid chromatography (HPLC). Adenoma patients were discriminated from controls based on AA and microbial composition. Levels of proline (p = .001), ornithine (p = .02) and serine (p = .02) were increased in adenoma patients compared to controls but decreased to resemble those of controls after adenoma removal. These AAs were combined as a potential adenoma-specific panel (AUC 0.79(0.64–0.94)). For bacterial taxa, differences between patients with adenomas and controls were found (Bifidobacterium spp.↓, Anaerostipes spp.↓, Butyricimonas spp.↑, Faecalitalea spp.↑ and Catenibacterium spp.↑), but no alterations in relative abundance were observed after polypectomy. Furthermore, Faecalitalea spp. and Butyricimonas spp. were significantly correlated with adenoma-specific amino acids. We selected an amino acid panel specifically increased in the presence of adenomas and a microbial signature present in adenoma patients, irrespective of polypectomy. Upon validation, these panels may improve the effectiveness of the surveillance program by detection of high-risk individuals and determination of surveillance endoscopy timing, leading to less unnecessary endoscopies and less interval cancer.
Prevention of mother-to-child transmission of hepatitis B: birth-dose vaccination is not enough
Authors: Jean Jacques Noubiap, Shalom Tchokfe Ndoula
Journal: The Lancet Global Health (2022)

Hepatitis B virus (HBV) infection is an important contributor to the global burden of disease. Globally, 296 million people are living with chronic HBV infection, including 6 million children younger than 5 years, and about 1·5 million people newly infected with HBV annually.1 Furthermore, cirrhosis and hepatocellular carcinoma resulting from chronic HBV infection cause about 820 000 deaths per year.1 In 2016, WHO adopted the Global Health Sector Strategy on viral hepatitis, which called for a reduction of HBV incidence by 90% and mortality by 65% by 2030.
Short Notes on the Opinions and Practice of the Late John Pearson, Esq., F.R.S., on Syphilitic Disease
Authors: W. S. Oke
Journal: BMJ (1848)

theie' sereted, that it does not enter into any organic onzction with.the elements of the kidney, but merely ercolits in s0olution through it; hence the disease of She kidfiey must be secondary.The sugar doubtless rches the kidney in solution in the blood, and there acts upon that orgaui as a ditretic, passing possibly dissolved in thiewater that filters through the Malpighian bodies, and not being attracted from the blood through the wall 'of the tubes."5. The comparative conditions of the epithelium of the liver and kidneys are very singular, and I am not ,aware that a similar observation has been previously made; it would tend to shew with what avidity all carbonaceous matters, fat as well as sugar, are directed to the kidney, in this disease.Most probably, to some extent, the fat of the liver goes, in common with fat from other parts of the body, to the formation of sugar; but this does not account for the deposition of fat in the epitheium of the kidneys.L"tly, these cases justify the conclusion that this disease is essentially one of the primary organs of digestion, whereby all substances readily convertible into sugar are quickly so converted; and that sugar is not 4igested, but passes into the blood unchanged, whence it is rapidly eliminated by the kidneys.We must not forget that this was, in fact, the view taken of this disease by Dr. Rollo, an English physician, who was the first to suggest the plan of treatment, which all experience proves to be the most beneficial.
Leg ulcers
Authors: H. Dudley
Journal: BMJ (1988)

Careful inspection of the mean values published in the paper show that it is feasible to take a series of garments from within a range and find that they perform in a satisfactory manner-that is, they provide linear graduation and are effective in terms of the particular aspect of venous function which we studied.Our critics, however, have failed to grasp the importance of the work if they do not appreciate that it is important that these criteria should extend throughout the range of garments and be applicable to any of the size ranges supplied by the manufacturer.Further study ofthe materials they quote2 shows that it was necessary for a range of stockings to be manufactured specifically for this study so that graduated compression could be achieved across the patient group.We agree that further work is required, and want to make clear that our study was carried out independently of any manufacturer support; it was undertaken in the interest of applied physiology and the desire to improve the quality of care available to this often neglected group of patients based on objective data that are applicable to the individual subject.