tbuckley/cabot-search huggingface dataset:
Abstract 232: Delayed Administration of Epinephrine is Associated with Worse Neurological Outcomes in Patients with Out-of-hospital Cardiac Arrest and Initial Pulseless Electrical Activity
Authors: Nobuyuki Enzan, Ken-ichi Hiasa, Kenzo Ichimura, Masaaki Nishihara, Takeshi Iyonaga, Yuji Shono, Takanari Kitazono, Hiroyuki Tsutsui
Journal: Circulation (2020)

Background: Delayed administration of epinephrine has been proven to worsen the neurological outcomes of patients with out-of-hospital cardiac arrest (OHCA) and initial shockable rhythm. We aimed to investigate whether delayed administration of epinephrine might also worsen the neurological outcomes of patients with witnessed OHCA and initial pulseless electrical activity (PEA). Methods: The Japanese Association for Acute Medicine - out-of-hospital cardiac arrest (JAAM-OHCA) Registry is a multicenter, prospective, observational registry including 34,754 OHCA patients between 2014 and 2017. The present study assessed the impact of the time to epinephrine administration on neurological outcomes in patients with witnessed non-traumatic OHCA with initial rhythm of PEA. The primary outcome was defined as Cerebral Performance Categories (CPC) Scale 1-2 at 30 days after OHCA. The association between the odds ratio for the primary outcome and the time from witnessed OHCA to epinephrine administration was assessed with a restricted cubic spline analysis. Results: Out of 34,754 patients with OHCA, 3,050 patients with OHCA and initial PEA who received epinephrine were included in the present study. Mean age was 73.7 years and 1836 (60.2%) was male. After adjusting for potential confounders, the time from witnessed OHCA to epinephrine administration was associated with lower likelihood of favorable neurological outcomes (odds ratio [OR] 0.92; 95% confidence interval [CI] 0.89-0.96; P&amp;lt;0.001). The restricted cubic spline analysis demonstrated that delayed epinephrine administration could decrease the likelihood of a favorable neurological outcome; this was significant within the first 10 minutes. Conclusions: Delayed administration of epinephrine was associated with worse neurological outcomes in patients with witnessed OHCA patients with initial PEA.
Identifying and appraising patient‐reported outcome measures on treatment satisfaction in acne: a systematic review*
Authors: E.J. van Zuuren, B.W.M. Arents, M. Miklas, J.W. Schoones, J. Tan
Journal: British Journal of Dermatology (2020)

After dermatitis, acne is the next skin disease to contribute most to the burden of skin diseases worldwide. Recently, seven core outcome domains have been identified, which together form an Acne Core Outcome Set (ACORN). One of these was satisfaction with acne treatment.To identify studies that described the development of patient-reported outcome measures (PROMS), evaluated one or more measurement properties of a PROM, or evaluated the interpretability of a PROM in patients with acne regarding treatment satisfaction.The COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) search strategy for identifying PROMS on acne treatment satisfaction was used. We searched PubMed, MEDLINE, Embase, LILACS, Web of Science, Cochrane Library, Emcare, PsycINFO and Academic Search premier (June 2020). Study selection, data extraction and assessment of methodological quality according to COSMIN guidance were carried out independently by two authors.Only one study could be included, describing the development of a treatment satisfaction measure in patients with acne. The development was assessed as inadequate and data on measurement properties were lacking. Additionally, we found 188 studies reporting treatment satisfaction solely as an outcome, using a wide variety of methods, none of them standardized or validated.We could not find a PROM on treatment satisfaction to recommend for a core outcome set in acne. There is an unmet need for a PROM on treatment satisfaction in acne that is robustly developed, designed and validated.
Abstract 14916: Clonal Analysis of the Neonatal Mouse Heart Using Nearest Neighbor Modeling
Authors: Melanie Bakovic, Devang Thakkar, Paige DeBenedittis, Diana Chong, Michael Thomas, Edwin Iversen, Ravi - Karra
Journal: Circulation (2020)

Introduction: Heart regeneration has been proposed as a treatment for heart failure. However, the challenge of detecting bona fide heart regeneration has complicated the validation of potential regenerative factors. We sought to develop a method for quantifying cardiomyogenesis in the mouse heart using multicolor lineage tracing. Hypothesis: We hypothesized that multicolor lineage tracing in combination with modeling of nearest neighbor distances could be used to quantify clonal expansion of cardiomyocytes (CMs) during growth and regeneration. Methods: Myh6- MerCreMer ; R26R-Rainbow bitransgenic mice underwent cryoinjury (CI) or sham injury on postnatal day 1 (P1). Tamoxifen was then administered such that limited numbers of CMs were randomly labeled with mCerulean, mOrange, or mCherry fluorophores. Hearts were collected at 21 days post CI. We analyzed a total of 81 sections, across 6 hearts (3 with sham injury and 3 with cryoinury). Images of entire cardiac sections were manually segmented to generate positional information for each labeled CM. Results: We used the nearest neighbor distributions of CMs carrying the same fluorophore and CMs carrying different fluorophores to develop a Bayesian model for estimating the probability that two CMs are clonally related. We found that, across a range of recombination efficiency, CMs carrying the same fluorophore within 30 μm are likely to be clonally related. By classifying CMs based on this distance threshold, we were able to confirm that clonally related CMs are smaller than non-clonally related CMs (165.20 ± 13.79 μm 2 vs 252.37 ± 20.51 μm 2 , p = 0.007, Welch t-test). We also confirmed that rates of cardiomyogenesis in cryoinjured and sham injured hearts are approximately the same (8.57 ± 2.69 % in cryoinjured hearts vs 9.45 ± 1.23 % in sham hearts, p=0.788). Conclusions: We have developed a robust and objective approach for quantifying cardiomyogenesis in the mouse heart. This method can be applied to studies of heart regeneration and can also be adapted to other tissues.
Abstract 13917: <i>O</i> -GlcNAc Levels Are Regulated in a Time and Tissue Specific Manner Independently of Dietary Intake
Authors: Thomas DUPAS, Manon DENIS, Justine Dontaine, Antoine Persello, Laurent Bultot, Angelique Erraud, Didier Vertommen, Bertrand Bouchard, Arnaud tessier, Jacques Lebreton, Jérôme Montnach, Michel De Waard, Chantal Gauthier, Yan Burelle, Aaron K Olson, Bertrand R Rozec, Christine Des Rosiers, Luc Bertrand, Tarik Issad, Benjamin Lauzier
Journal: Circulation (2020)

Background: O -GlcNAcylation ( O -GlcNAc) is a post-translational modification involved in the stress response. A single pair of enzymes, O -GlcNAc transferase (OGT) and O -GlcNAcase (OGA) controls the O -GlcNAcylation. Due to the contribution of energy-linked metabolites (e.g. glucose, glutamine, etc.) to produce UDP-GlcNAc, the substrate used by OGT, O -GlcNAc is considered as a nutrient sensor. Metabolic sources vary from carbohydrates in utero , to fatty acids after birth then a mix once adult. Yet the link between diet composition and O -GlcNAc has never been explored. Purpose: Evaluate changes in O -GlcNAc levels and regulatory mechanisms throughout development. Methods: Organs were harvested from Wistar rats (n=6-8 for each group) before and after birth (D-1 and D0), in suckling animals (D12), after weaning with a standard (D28) or a carbohydrate free diet (D28F), and adult (D84). O -GlcNAc levels and regulatory enzymes were evaluated by Western blots. Mass spectrometry (MS) was performed to quantify known regulators of O -GlcNAc (n=6-8) and identify cardiac O -GlcNAcylated proteins at D0 and D28 (n=2). Results: O -GlcNAc levels fell after birth in the heart, brain and liver (2.5, 1.5 and 1.3-fold, respectively). Interestingly, while O -GlcNAc levels decrease progressively from D0 to D84 (5.75-fold p&lt;0.05) in the heart, the O -GlcNAc changes are opposite and of much smaller magnitude in liver and brain. Regulatory mechanisms appear to be in accordance in heart with a decrease in OGT (4.5-fold; p&lt;0.05), an increase in OGA (125-fold; p&lt;0.05) expression and decrease in UDP-GlcNAc (3-fold; p&lt;0.05) over time. Yet changes in expression of OGT, OGA and UDP-GlcNAc do not follow O -GlcNAc levels in brain and liver. O -GlcNAc levels are unaffected by weaning diet in any tissues. MS analyses identified changes in cardiac levels of specific O -GlcNAcylated proteins, namely those involved in the energy metabolism, such as ACAT1, which is only O -GlcNAcylated at D0. Conclusion: We demonstrate that O -GlcNAc levels are not linked to dietary intake and are regulated in a time and tissue-specific manner during postnatal development. We have identified by MS proteins with a particular O -GlcNAc signature across the development process suggesting specific role for those proteins.
Abstract 14666: Association Between Right Ventricular Systolic Pressure and Health Status Following Transcatheter Aortic Valve Replacement
Authors: Rahul Myadam, Ali O Malik, Matthew Pflederer, Kensey Gosch, Suzanne V Arnold, Adnan Chhatriwalla
Journal: Circulation (2020)

Introduction: Pulmonary hypertension (PH) was shown in multiple studies to be associated with an increased risk of mortality after transcatheter aortic valve replacement (TAVR). However, it is unclear if echocardiogram derived right ventricular systolic pressure (RVSP) is associated with health status outcomes in surviving patients after TAVR. We explored for an association between baseline RVSP and quality of life in patients before and after undergoing TAVR. Methods: We estimated RVSP by echocardiography using the modified Bernoulli equation in a single-center cohort of patients undergoing TAVR from 2012-2017 . Disease-specific health status was assessed at baseline and 1-month and 12-months after TAVR with the Kansas City Cardiomyopathy Questionnaire-Overall Summary Score (KCCQ-OS). We then explored the association between baseline RVSP and KCCQ-OS before and after TAVR using a linear mixed model with an interaction for time and baseline RVSP and adjusted for baseline mitral valve regurgitation and systolic blood pressure. Results: Among 485 patients who underwent TAVR (mean age 81.7±7.9 years, 54.8% men), baseline RVSP was 42±15 mmHg, and 73% had RVSP &gt;34 mmHg. After TAVR, mean RVSP decreased to 37±13 mmHg at 1 month and 36±14 mmHg at 12 months. Baseline KCCQ-OS was 46±25 and improved to 66.9±23.6 at 1 month and 69.5± 22.6 at 12 months. In the linear mixed model, there was a significant cross-sectional association between baseline RVSP and baseline KCCQ-OS, with higher RVSP associated with worse health status. However, baseline RVSP was not significantly associated with KCCQ-OS at 1 month or 12 months (Figure). Conclusions: RVSP is not associated with worse health status after TAVR. This suggests that while patients with high RVSP are at an increased risk for mortality after TAVR, surviving patients appear to have similar health status as those with normal RVSP.
Abstract 17197: Donor Circumstance and Mechanism of Death: Evolving Effects on Heart Transplant Recipient Survival
Authors: Benjamin Smood, J. Trent Magruder, Amit Iyengar, William L. Patrick, Jason J. Han, Mark Helmers, John J. Kelly, Nimesh Desai, Marisa Cevasco
Journal: Circulation (2020)

Introduction: Since 2000, suicide rates have dramatically increased, while deaths from motor vehicle accidents (MVAs) have declined. Poisoning has surpassed MVAs as the leading cause of preventable death, largely due to the opioid epidemic. Analyses regarding the forensic pathology of donor death and heart transplant recipient outcomes are lacking. We sought to determine how donor mechanisms (e.g. drug intoxication, asphyxiation) and circumstances (e.g. suicide, MVA) of death have affected heart transplant outcomes over the last 20 years. Methods: The UNOS database was queried for all first-time isolated heart transplants occurring between January 2000 through March 2019. First-time recipients were included. Donor, recipient, and procurement variables were screened by univariable logistic analysis to identify potential independent predictors of survival with freedom from transplantation at 1 year after heart transplant. A final parsimonious multivariable regression model was created, including all causes, mechanisms and circumstances of donor death. The primary endpoint of analysis was survival with freedom from retransplantation at last follow-up. Analyses were conducted for 2000-19, and stratified by decade (2000-09 and 2010-19). Results: 34,373 patients met inclusion criteria. Median follow-up was 4.3 (IQR1.3-8.9) years. From 2000-19, death by suicide has had worse overall survival (HR 1.27; CI 1.1-1.5). A similar association is seen prior to 2010 (HR1.36; CI1.06-1.74). Since 2010, death by asphyxiation has been associated with improved survival (HR0.7; CI0.5-0.9). Death by MVA has become associated with early (i.e. 30-day) mortality (HR1.7; CI1.1-2.7), and worse survival among patients surviving 1-year after transplant. Donor death from drug intoxication has had no significant effect on recipient outcomes in the past 20 years. Conclusions: Since 2010, donors who died by MVA have worse early survival in heart transplant. Death by asphyxiation now appears to have a protective effect on overall survival. Suicide is no longer associated with poorer outcomes. Further study into how public health initiatives, policy, and epidemics effect transplant outcomes may improve donor selection and organ allocation in heart transplantation.
Abstract 15007: Association Of Dual Eligibility For Medicare And Medicaid With Heart Failure Quality And Outcomes Among Gwtg-hf Hospitals
Authors: Ehete M Bahiru, Boback Ziaeian, Corrina Moucheraud, Anubha Agarwal, Xu Haolin, Roland A Matsouak, Adam D Devore, Paul A Heidenreich, Larry A Allen, Clyde W Yancy, Gregg C Fonarow
Journal: Circulation (2020)

Introduction: The Centers for Medicare &amp; Medicaid Services (CMS) is using a new peer group-based payment system to compare hospital performance which classifies hospitals into quintiles based on their share of dual eligible beneficiaries for Medicare and Medicaid. This study evaluated the association of percent dual eligibility for Medicare Medicaid with HF quality of care and outcomes. Methods: This is a retrospective analysis of patients hospitalized for HF using the Get With The Guidelines-HF (GWTG-HF) registry between July, 1 2010 - December 31, 2017. Study endpoints included HF process of care measures, in-hospital mortality, 30-day all-cause or HF readmissions, 30-day all-cause mortality. We included patients aged ≥65 years old with available data on dual eligibility status. Hospitals were divided into quintiles based on their share dual eligible patients. Quality and outcomes were analyzed using unadjusted and adjusted multivariable logistic regression models. Results: A total of 258,995 HF hospitalizations from 455 sites were included in the primary analysis of the study. Hospitals in the highest dual eligibility quintile (Q5) tended to care for patients who were younger, more likely female, belong to racial minority groups, or located in rural areas compared with Q1 sites. After multivariable adjustment, hospitals with the highest quintile of dual eligibility (Q5 sites) were associated with lower rates of key process measures including evidence-based beta blocker prescription (aOR: 0.70, 95% CI [0.52,0.94]), measure of left ventricular function (aOR: 0.39, 95% CI [0.21,0.72]), anticoagulation for atrial fibrillation or atrial flutter (aOR: 0.68, 95% CI [0.51,0.91]). Differences in clinical outcomes were seen with higher 30-day all-cause (aOR: 1.24, 95% CI [1.14,1.35]) and HF (aOR: 1.14, 95% CI [1.03,1.27]) readmissions in higher dual eligible Q5 sites compared to Q1 sites. Risk-adjusted in-hospital and 30-day mortality did not significantly differ in Q1 vs Q5 hospitals. Conclusions: Higher dual eligibility quintile sites were associated with lower rates of key HF quality of care process measures and higher 30-day all-cause or HF readmissions compared to lower dual eligibility quintile sites.
Efficacy of a Russian-backbone live attenuated influenza vaccine among young children in Bangladesh: a randomised, double-blind, placebo-controlled trial
Authors: W Abdullah Brooks, K Zaman, Kristen D C Lewis, Justin R Ortiz, Doli Goswami, Jodi Feser, Amina Tahia Sharmeen, Kamrun Nahar, Mustafizur Rahman, Mohammed Ziaur Rahman, Burc Barin, Muhammad Yunus, Alicia M Fry, Joseph Bresee, Tasnim Azim, Kathleen M Neuzil
Journal: The Lancet Global Health (2016)

The rates of influenza illness and associated complications are high among children in Bangladesh. We assessed the clinical efficacy and safety of a Russian-backbone live attenuated influenza vaccine (LAIV) at two field sites in Bangladesh.Between Feb 27 and April 9, 2013, children aged 2-4 years in urban Kamalapur and rural Matlab, Bangladesh, were randomly assigned in a 2:1 ratio, according to a computer-generated schedule, to receive one intranasal dose of LAIV or placebo. After vaccination, we monitored children in weekly home visits until Dec 31, 2013, with study clinic surveillance for influenza illness. The primary outcome was symptomatic, laboratory-confirmed influenza illness due to vaccine-matched strains. Analysis was per protocol. The trial is registered with ClinicalTrials.gov, number NCT01797029.Of 1761 children enrolled, 1174 received LAIV and 587 received placebo. Laboratory-confirmed influenza illness due to vaccine-matched strains was seen in 93 (15·8%) children in the placebo group and 79 (6·7%) in the LAIV group. Vaccine efficacy of LAIV for vaccine-matched strains was 57·5% (95% CI 43·6-68·0). The vaccine was well tolerated, and adverse events were balanced between the groups. The most frequent adverse events were tachypnoea (n=86 in the LAIV group and n=54 in the placebo group), cough (n=73 and n=43), and runny nose (n=68 and n=39), most of which were mild.This single-dose Russian-backbone LAIV was safe and efficacious at preventing symptomatic laboratory-confirmed influenza illness due to vaccine-matched strains. LAIV programmes might reduce the burden of influenza illness in Bangladesh.The Bill & Melinda Gates Foundation.
THU0151 High frequency of reduced bone mass in men with rheumatoid arthritis
Authors: B Tengstrand, K Carlström, I Hafström
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> <h3>Objectives</h3> Osteoporosis is a well known complication of rheumatoid arthritis (RA). Both osteoporosis and RA are diseases predominantly affecting women. The aim of this study was to investigate the bone mineral density (BMD) in Scandinavian males with RA and to analyse the impact of different disease dependent and disease independent variables on bone health. <h3>Methods</h3> Bone mineral measurements were done in 103 male RA patients attending a referral clinic of rheumatology. The BMD values were correlated with rheumatoid factor (RF), duration of disease, presence of erosions, degree of inflammation (DAS28), functional capacity (HAQ), treatment, levels of biologically active testosterone, body mass index (BMI) and smoking. <h3>Results</h3> The patients were 20–70 years old with a median disease duration of 4 years (range 0–43). They had small but significant reductions in their BMD compared with an age and gender matched reference population (z scores). The mean BMD was lowered 6%(p &lt; 0,01) in femoral neck, 6%(p &lt; 0,01) in the trochanteric region, 7%(p &lt; 0,01) in the region of Ward, and 4%(p &lt; 0.05) in the spine. However, a substantial proportion of the patients had reduced bone mass defined as BMD lower than -1SD(z score). Thus 45/98 had reduced bone mass in femoral neck and 47/102 in the spine which is far more than the expected 16%. Z-scores at Wards triangle correlated with disease duration and presence of erosions. At trochanter z-scores correlated with duration of disease, erosions, HAQ, as well as BMI. The best multiple regression analysis with HAQ, erosions and BMI explained 22% of the variance. At femoral neck z-scores did not correlate to any of the tested variables. At spine (L2-L4) only erosions were significant correlated with z-scores. Sulphasalazine had a statistically significant positive correlation to the bone in Ward´s triangle and trochanter while methotrexate had a negative correlation to the bone in the trochanter region. Neither in correlation analysis nor in multiple regression analysis there were any correlations between z-scores at hip or spine and RF, current degree of inflammation, treatment with glucocorticoids, parenteral gold or ciclosporin, levels of biologically active testosteron or smoking in any of the skeletal sites measured. <h3>Conclusion</h3> A substantial proportion of males with RA had reduced bone mass. Variables that reflect structural damage had large impact on bone mineral density.
Abstract 15694: Atrial Tachycardia Masquerading as Sinus Tachycardia - Electrophysiological Characteristics and Ablation Outcomes
Authors: Rakesh Gopinathannair, Krishna Akella, Ghulam Murtaza, Luigi Di Biase, Andrea Natale, Dhanunjaya Lakkireddy, Pugazhendhi Vijayaraman
Journal: Circulation (2020)

Background: Focal atrial tachycardia (AT) is typically distinguished by P wave morphology and autonomic response. AT arising close to the sinus node can be easily misdiagnosed as Inappropriate sinus tachycardia (IST). Objective: This multicenter study sought to describe the electrophysiological (EP) features and ablation outcomes of perisinus node atrial tachycardia (PNAT). Methods: Baseline as well as procedural characteristics and outcome data of 7 patients with PNAT are described. Results: Mean age of the cohort was 38±17 years (100% female). Time from symptom onset to diagnosis was12.2± 9 months with an average of 1.7 prior hospitalizations. Mean baseline HR was127.8 bpm and all patients carried a diagnosis of IST. Baseline ECG in all patients was identical to sinus tachycardia, with exception of taller P waves in lead II in 5 patients and deeper negative component of P wave in V1. At EP study, mean AT cycle length was 420 msec and significant acceleration was seen with isoproterenol, mimicking IST. Activation mapping was done using Ensite TM Balloon Array (5), Precision TM (1) and Carto TM (1). Site of origin was slightly anterolateral to sinus node in 3 and anterior, inferior and medial to sinus node in 4 (Figure). AT was successfully ablated in all patients without any phrenic injury or sinus node dysfunction. Over 2.9 years of follow-up, only 1 patient had recurrence that was successfully re-ablated. Conclusion: PNAT has similar ECG and EP characteristics and is often misdiagnosed as IST. A high index of suspicion is needed for diagnosis. Evaluation of P wave morphology during tachycardia and careful activation mapping can enable successful ablation with excellent long-term outcomes.
Upregulation of enteric alpha-synuclein as a possible link between inflammatory bowel disease and Parkinson’s disease
Authors: Pascal Derkinderen, Wendy Noble, Michel Neunlist, Malvyne Rolli-Derkinderen
Journal: Gut (2020)

come from teaching and research institutions in France or abroad, or from public or private research centers.L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Upregulation of enteric alpha-synuclein as a possible link between inflammatory bowel disease and Parkinson's diseasePascal Derkinderen, Wendy Noble, Michel Neunlist, Malvyne