tbuckley/cabot-search huggingface dataset:
Decoding the multicellular ecosystem of vena caval tumor thrombus in clear cell renal cell carcinoma by single-cell RNA sequencing
Authors: Yue Shi, Qi Zhang, Hai Bi, Min Lu, Yezhen Tan, Daojia Zou, Liyuan Ge, Zhigang Chen, Cheng Liu, Weimin Ci, Lulin Ma
Journal: Genome biology (2022)

Abstract Background Vascular invasion with tumor thrombus frequently occurs in advanced renal cell carcinoma (RCC). Thrombectomy is one of the most challenging surgeries with high rate of perioperative morbidity and mortality. However, the mechanisms driving tumor thrombus formation are poorly understood which is required for designing effective therapy for eliminating tumor thrombus. Results We perform single-cell RNA sequencing analysis of 19 surgical tissue specimens from 8 clear cell renal cell carcinoma (ccRCC) patients with tumor thrombus. We observe tumor thrombus has increased tissue resident CD8 + T cells with a progenitor exhausted phenotype compared with the matched primary tumors. Remarkably, macrophages, malignant cells, endothelial cells and myofibroblasts from TTs exhibit enhanced remodeling of the extracellular matrix. The macrophages and malignant cells from primary tumors represent proinflammatory states, but also increase the expression of immunosuppressive markers compared to tumor thrombus. Finally, differential gene expression and interaction analyses reveal that tumor-stroma interplay reshapes the extracellular matrix in tumor thrombus associated with poor survival. Conclusions Our comprehensive picture of the ecosystem of ccRCC with tumor thrombus provides deeper insights into the mechanisms of tumor thrombus formation, which may aid in the design of effective neoadjuvant therapy to promote downstaging of tumor thrombus and decrease the perioperative morbidity and mortality of thrombectomy.
Abstract P4-11-10: Association of sports activity during the first five years of survival with quality of life among Chinese breast cancer survivors
Authors: Winnie Yeo, Yuanyuan Lei, Kali Cheung, Roselle Lee, Carol Kwok, Ashely Cheng, Ashely Cheng, Frankie Mo, Suzanne Ho
Journal: Cancer Research (2022)

Abstract Background: The objective of this study was to investigate the association between participation of sports activity (SA) and quality of life (QoL) among Chinese women with early stage breast cancer (BC) during the first five years post BC diagnosis. Methods: BC survivors underwent assessment of QoL and level of SA at 3 time-points: 18-, 36- and 60-months after diagnosis. SA was measured using a validated modified Chinese Baecke questionnaire in the prior 12 months; QoL was measured using EORTC-QLQC30. Results: In total, 1289, 1125 and 1116 BC survivors were included at 18-, 36- and 60-month follow-up, respectively. At 18-month, the percentages of patients belonged to no [0 metabolic equivalent of task (MET)-hours per week], low-level (&amp;lt;10 MET-hours/week) and high-level (≥10 MET-hours/week) SA groups were 20.7%, 45.5% and 33.8%, respectively; the corresponding figures at 36-month were 29.4%, 38.9% and 31.6%, respectively; and tat of 60-month were 32.8%, 36.7% and 30.5%, respectively. Generalized Estimating Equations analyses showed that higher level of SA was associated with better QoL in several items, including global health status/QoL, physical functioning, role functioning and emotional functioning (P for trend &amp;lt; 0.05 for all), as well as less symptoms in fatigue, pain, loss of appetite and constipation (P for trend &amp;lt; 0.05 for all). Conclusions: Findings from the present study support the notion that SA has beneficial effect on QoL during the first 5 years of BC survivorship. Health promotion programs should encourage participation for SA after breast cancer diagnosis.Acknowledgements: This work was supported by World Cancer Research Fund International (Grant Number WCRF 2010/249 and WCRF 2014/1197) and Madam Diana Hon Fun Kong Donation for Cancer Research. Citation Format: Winnie Yeo, Yuanyuan Lei, Kali Cheung, Roselle Lee, Carol Kwok, Ashely Cheng, Ashely Cheng, Frankie Mo, Suzanne Ho. Association of sports activity during the first five years of survival with quality of life among Chinese breast cancer survivors [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P4-11-10.
Risk of breast cancer with HRT depends on therapy type and duration
Authors: Helen Saul, Deniz Gursul, Samantha Cassidy, Yana Vinogradova
Journal: BMJ (2022)

The studyVinogradova Y, Coupland C, Hippisley-Cox J. Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases. BMJ 2020;371:m3873. To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/risk-of-breast-cancer-with-hrt-depends-therapy-type-and-duration/.
Rapamycin limits CD4+ T cell proliferation in simian immunodeficiency virus–infected rhesus macaques on antiretroviral therapy
Authors: Benjamin D. Varco-Merth, William Brantley, Alejandra Marenco, Derick D. Duell, Devin N. Fachko, Brian Richardson, Kathleen Busman-Sahay, Danica Shao, Walter Flores, Kathleen Engelman, Yoshinori Fukazawa, Scott W. Wong, Rebecca L. Skalsky, Jeremy Smedley, Michael K. Axthelm, Jeffrey D. Lifson, Jacob D. Estes, Paul T. Edlefsen, Louis J. Picker, Cheryl M.A. Cameron, Timothy J. Henrich, Afam A. Okoye
Journal: Journal of Clinical Investigation (2022)

Proliferation of latently infected CD4+ T cells with replication-competent proviruses is an important mechanism contributing to HIV persistence during antiretroviral therapy (ART). One approach to targeting this latent cell expansion is to inhibit mTOR, a regulatory kinase involved with cell growth, metabolism, and proliferation. Here, we determined the effects of chronic mTOR inhibition with rapamycin with or without T cell activation in SIV-infected rhesus macaques (RMs) on ART. Rapamycin perturbed the expression of multiple genes and signaling pathways important for cellular proliferation and substantially decreased the frequency of proliferating CD4+ memory T cells (TM cells) in blood and tissues. However, levels of cell-associated SIV DNA and SIV RNA were not markedly different between rapamycin-treated RMs and controls during ART. T cell activation with an anti-CD3LALA antibody induced increases in SIV RNA in plasma of RMs on rapamycin, consistent with SIV production. However, upon ART cessation, both rapamycin and CD3LALA–treated and control-treated RMs rebounded in less than 12 days, with no difference in the time to viral rebound or post-ART viral load set points. These results indicate that, while rapamycin can decrease the proliferation of CD4+ TM cells, chronic mTOR inhibition alone or in combination with T cell activation was not sufficient to disrupt the stability of the SIV reservoir.
TUMESCENT LOCAL ANESTHESIA VERSUS GENERAL ANESTHESIA FOR SUBCUTANEOUS IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR IMPLANTATION: A COST-EFFECTIVE ANALYSIS
Authors: Sutopa Purkayastha, Jorge Enrique Romero, Juan Diaz, Juan Bello, Mohamed Gabr, Isabella Alviz, Aung Lin, Jose Matias, Joan Rodriguez-Taveras, Luigi Di Biase
Journal: Journal of the American College of Cardiology (2022)
STENTING OF RIGHT VENTRICULAR OUTFLOW TRACT AS A BRIDGE TO DEFINITE TREATMENT IN 40-YEAR OLD TETRALOGY OF FALLOT PATIENT: A CASE REPORT
Authors: Radityo Prakoso, Yovi Kurniawati, Sisca Natalia Siagian, Damba Dwisepto Aulia Sakti, Brian Mendel, Lilyasari Oktavia
Journal: Journal of the American College of Cardiology (2022)
Readmissions in the Year After Percutaneous Coronary Intervention
Authors: James Blankenship, Imran Baig, Amir Eslami, Andrea Berger, Cara Nordberg
Journal: Clinical Cardiology and Cardiovascular Interventions (2022)

Prior studies of readmission have evaluated correlates of 30-day readmission but have not evaluated correlates of readmission after 30 days. The study sought to evaluate factors associated with re-hospitalization within one year of undergoing percutaneous coronary intervention (PCI). We analyzed 6265 patients treated at Geisinger hospitals with PCI between January 2010 and December 2015. Correlates of readmission within 1 year were identified. Sub-groups were compared based on reason for readmission (related to versus not related to ischemic heart disease) and timing of readmission (1-30 days versus 31-365 days). Mean age was 64.3 years, 70% were male, and 98.8% were Caucasian. In the first year after PCI, 2,767 patients (44.2%) were re-admitted. Within 30 days 931 patients (14.9%) were readmitted; 1836 (29.3%) were readmitted between 31 and 365 days. Nine hundred fifty (15.2%). In summary, in an unselected patient cohort treated with PCI, approximately 44% of the patients were readmitted within one year. Two-thirds of these were admitted after the first month. Efforts to prevent the need for readmission should continue beyond the first month post-discharge and center on risk factor modification.
Heterotypic transcriptional condensates formed by prion-like paralogous proteins canalize flowering transition in tomato
Authors: Xiaozhen Huang, Nan Xiao, Yupan Zou, Yue Xie, Lingli Tang, Yueqin Zhang, Yuan Yu, Yiting Li, Cao Xu
Journal: Genome biology (2022)

Abstract Background Paralogs that arise from gene duplications during genome evolution enable genetic redundancy and phenotypic robustness. Variation in the coding or regulatory sequence of paralogous transcriptional regulators diversifies their functions and relationships, which provides developmental robustness against genetic or environmental perturbation. The fate transition of plant shoot stem cells for flowering and reproductive success requires a robust transcriptional control. However, how paralogs function and interact to achieve such robustness is unknown. Results Here, we explore the genetic relationship and protein behavior of ALOG family transcriptional factors with diverse transcriptional abundance in shoot meristems. A mutant spectrum covers single and higher-order mutant combinations of five ALOG paralogs and creates a continuum of flowering transition defects, showing gradually enhanced precocious flowering, along with inflorescence simplification from wild-type-like to progressively fewer flowers until solitary flower with sterile floral organs. Therefore, these paralogs play unequal roles and act together to achieve a robust genetic canalization. All five proteins contain prion-like intrinsically disordered regions (IDRs) and undergo phase separation. Accumulated mutations following gene duplications lead to IDR variations among ALOG paralogs, resulting in divergent phase separation and transcriptional regulation capabilities. Remarkably, they retain the ancestral abilities to assemble into a heterotypic condensate that prevents precocious activation of the floral identity gene ANANTHA . Conclusions Our study reveals a novel genetic canalization mechanism enabled by heterotypic transcriptional condensates formed by paralogous protein interactions and phase separation, uncovering the molecular link between gene duplication caused IDR variation and robust transcriptional control of stem cell fate transition.
ADAR1-mediated RNA editing links ganglioside catabolism to glioblastoma stem cell maintenance
Authors: Li Jiang, Yajing Hao, Changwei Shao, Qiulian Wu, Briana C. Prager, Ryan C. Gimple, Gabriele Sulli, Leo J.Y. Kim, Guoxin Zhang, Zhixin Qiu, Zhe Zhu, Xiang-Dong Fu, Jeremy N. Rich
Journal: Journal of Clinical Investigation (2022)

Glioblastoma (GBM) is the most common and lethal primary malignant brain tumor, containing GBM stem cells (GSCs) that contribute to therapeutic resistance and relapse. Exposing potential GSC vulnerabilities may provide therapeutic strategies against GBM. Here, we interrogated the role of adenosine-to-inosine (A-to-I) RNA editing mediated by adenosine deaminase acting on RNA 1 (ADAR1) in GSCs and found that both ADAR1 and global RNA editomes were elevated in GSCs compared with normal neural stem cells. ADAR1 inactivation or blocking of the upstream JAK/STAT pathway through TYK2 inhibition impaired GSC self-renewal and stemness. Downstream of ADAR1, RNA editing of the 3'-UTR of GM2A, a key ganglioside catabolism activator, proved to be critical, as interference with ganglioside catabolism and disruption of ADAR1 showed a similar functional impact on GSCs. These findings reveal that RNA editing links ganglioside catabolism to GSC self-renewal and stemness, exposing a potential vulnerability of GBM for therapeutic intervention.
COMPLEX AND HIGH-RISK PERCUTANEOUS INTERVENTION WITH TRANSCATHETER AORTIC VALVE REPLACEMENT: ARE WE PUSHING THE LIMIT IN THE TREATMENT OF CORONARY ARTERY DISEASE AND AORTIC STENOSIS?
Authors: Arber Kodra, Denny Wang, Hamfreth S. Rahming, Angela Li, Hosam Hmoud, Craig Basman, Ahmad Mustafa, Sahar Mahani, Luigi Pirelli, Priti Mehla, Sridhar Uttara, Effe Mihelis, Bruce Rutkin, Elana Koss, Sean R. Wilson, Gregory A. Maniatis, Mohammed Nasir Imam, Puneet Gandotra, Robert Kalimi, Azhar A. Supariwala, Perwaiz M. Meraj, Nirav Patel, S. Jacob Scheinerman, Chad Kliger
Journal: Journal of the American College of Cardiology (2022)
COMPARATIVE EFFECT OF ANGIOTENSIN RECEPTOR/NEPRILYSIN INHIBITION ON B-TYPE NATRIURETIC PEPTIDE LEVELS MEASURED BY THREE DIFFERENT ASSAYS: THE PROVE-HF STUDY
Authors: Peder Langeland Myhre, Margaret Prescott, Brian Claggett, Michael Felker, Javed Butler, Ileana L. Pina, Alan S. Maisel, Kristin Williamson, Jonathan Ward, Scott D. Solomon, James L. Januzzi
Journal: Journal of the American College of Cardiology (2022)
NOVEL USE OF AMAZON 1-CLICK BUTTON TO SIGNIFICANTLY REDUCE TIME TO DIAGNOSIS OF ACUTE MYOCARDIAL INFARCTION IN EMERGENCY DEPARTMENT PATIENTS
Authors: Milind R. Dhond, Justin M. Hovey, Brian Johnson, Saba Lahsaei, Mark Leslie Villalon, Nicholas Borowsky, Jeffrey R. Breneisen
Journal: Journal of the American College of Cardiology (2022)
USE OF VASCULAR PLUG FOR TREATMENT OF RECURRENT SEVERE MITRAL REGURGITATION AFTER TRANSCATHETER EDGE-TO-EDGE REPAIR
Authors: Emily Hiltner, Enrique J. Pantin, Ashok Chaudhary, Abdul Hakeem, Partho P. Sengupta, Mark Russo, Ankur Sethi
Journal: Journal of the American College of Cardiology (2022)
I Love You
Authors: Cara Anne Poland
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Longitudinal analysis of ANA in the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort
Authors: May Yee Choi, Ann Elaine Clarke, Murray Urowitz, John Hanly, Yvan St-Pierre, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Daniel J Wallace, David Isenberg, Anisur Rahman, Joan T Merrill, Paul R Fortin, Dafna D Gladman, Ian N Bruce, Michelle Petri, Ellen M Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Jönsen, Graciela S Alarcón, Ronald F van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, Sam Lim, Murat Inanc, Ken Kalunian, Søren Jacobsen, Christine Peschken, Diane L Kamen, Anca Askanase, Jill P Buyon, Karen H Costenbader, Marvin J Fritzler
Journal: Annals of the Rheumatic Diseases (2022)

A perception derived from cross-sectional studies of small systemic lupus erythematosus (SLE) cohorts is that there is a marked discrepancy between antinuclear antibody (ANA) assays, which impacts on clinicians' approach to diagnosis and follow-up. We compared three ANA assays in a longitudinal analysis of a large international incident SLE cohort retested regularly and followed for 5 years.
SUPERIORITY OF NEW DYNAMIC CORONARY ANGIOGRAPHY TECHNIQUE BY SHOWING ANTEGRADE OR RETROGRADE, TURBULENT OR LAMINAR FLOW, AND SIMULTANEOUS PROXIMAL AND DISTAL CORONARY FLOWS
Authors: Thach N. Nguyen, Nguyen T. Phan, Tai Thien Tan Tri Truyen, Loc Vu, Phat H. Nguyen, Thoa Le, Gianluca Rigatelli, Ernest Talarico, Hung N. Pham, Dung Thuong Ho, Thinh Cao
Journal: Journal of the American College of Cardiology (2022)
Acellular nerve xenografts based on supercritical extraction technology for repairing long-distance sciatic nerve defects in rats
Authors: Shuai Wei, Qian Hu, Jianxiong Ma, Xiu Dai, Yu Sun, Gonghai Han, Haoye Meng, Wenjing Xu, Lei Zhang, Xinlong Ma, Jiang Peng, Yu Wang
Journal: Bioactive Materials (2022)
Intra-articular Platelet-Rich Plasma vs Placebo Injection and Pain and Medial Tibial Cartilage Volume in Patients With Knee Osteoarthritis—Reply
Authors: Kim L. Bennell, Kade L. Paterson, David J. Hunter
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue
Prevalence and risk factors of chronic urticaria in China: A nationwide cross‐sectional study
Authors: Xiao Zhang, Xiaoting Song, Mei Zhang, Chun Li, Zhengjing Huang, Bo Liu, Miao Yu, Shuanglu Liao, Tingting Luan, Torsten Zuberbier, Marcus Maurer, Zuotao Zhao, Limin Wang
Journal: Allergy (2022)

Dr. Zhao is the speaker/advisor for and/or has received research funding from Novartis, Pfizer, Astellas, Galderma, Janssen, GSK, BAYER, LEO, MEDA Pharma, and ALK Pharma, outside the submitted work. Dr. Zuberbier reports personal fees from Bayer Health Care, FAES, Novartis, Henkel, Novartis, Henkel, AstraZeneca Fee for talk, AbbVie Fee for talk, ALK Fee for talk, Almirall Fee for talk, Astellas Fee for talk, Bayer Health Care Fee for talk, Bencard Fee for talk, Berlin Chemie Fee for talk, FAES Fee for talk, HAL Fee for talk, Leti Fee for talk, Meda Fee for talk, Menarini Fee for talk, Merck Fee for talk, MSD Fee for talk, Novartis Fee for talk, Pfizer Fee for talk, Sanofi Fee for talk, Stallergenes Fee for talk, Takeda Fee for talk, Teva Fee for talk, UCB Fee for talk, Henkel Fee for talk, Kryolan Fee for talk, L'Oréal Fee for talk, all outside the submitted work. Dr. Maurer is the speaker/advisor for and/or has received research funding from Allakos, Alnylam, Amgen, Aralez, ArgenX, AstraZeneca, BioCryst, Blueprint, Celldex, Centogene, CSL Behring, Dyax, FAES, Genentech, GIInnovation, Innate Pharma, Kalvista, Kyowa Kirin, Leo Pharma, Lilly, Menarini, Moxie, Novartis, Pharming, Pharvaris, Roche, Sanofi/Regeneron, Shire/Takeda, Third HarmonicBio, UCB, and Uriach, outside the submitted work. The rest of the authors declare that they have no relevant conflicts of interest. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
IMPACT OF MODERATE AND SEVERE TRICUSPID REGURGITATION ON QUALITY-OF-LIFE OUTCOMES IN PATIENTS UNDERGOING TRANSATHETER AORTIC VALVE REPLACEMENT
Authors: Nicole E. Hoover, Lauren Curtis, Jawad Haider, Sean Robert McMahon, Bhaskar Arora, William Lane Duvall, Raymond G. McKay, Robert Hagberg
Journal: Journal of the American College of Cardiology (2022)
INDEPENDENT AND ADDITIONAL VALUE OF CARDIOPULMONARY EXERCISE TEST TO THE NEW YORK HEART ASSOCIATION CLASSIFICATION IN HEART FAILURE
Authors: Isabela Pilar Moraes Alves De Souza, Luiz Eduardo Fonteles Ritt, Anderson Silveira, João Victor Santos Pereira Ramos, Rebeca Sadigursky Ribeiro, Alexandre Meira Pazelli, Queila Borges Oliveira, Eduardo S. Darze, Ricardo Stein
Journal: Journal of the American College of Cardiology (2022)
CANGRELOR USE PATTERNS AND TRANSITION TO ORAL P2Y12 INHIBITORS AMONG PATIENTS WITH MYOCARDIAL INFARCTION: INITIAL INSIGHTS FROM THE CAMEO (CANGRELOR IN ACUTE MYOCARDIAL INFARCTION: EFFECTIVENESS AND OUTCOMES) REGISTRY
Authors: Jennifer Rymer, Deepak L. Bhatt, Dominick J. Angiolillo, Miguel A. Diaz, Kirk N. Garratt, Ron Waksman, Laura Edwards, Gudaye Tasissa, Khalid Salahuddin, Hijrah El-Sabae, Carmen Dell’Anna, Linda Davidson-Ray, Jeffrey B. Washam, Erik Magnus Ohman, Tracy Wang
Journal: Journal of the American College of Cardiology (2022)
Abstract P1-24-04: Spatially resolved cell type heterogeneity uncovers the distinct biology of inflammatory breast cancer
Authors: Elise Courtois, William Flynn, Santhosh Sivajothi, Martine Seignon, Diane Luo, Bora Lim, Paul Robson
Journal: Cancer Research (2022)

Abstract Inflammatory breast cancer (IBC) is the most lethal form of breast cancer due to rapid progression, distinct morbidity due to pain, swelling, infection and eventual death. It accounts for 10% of all breast cancer caused deaths despite being only 2-4% of all breast cancer diagnosis. Histopathologically, scattered tumor emboli and dermal lymphatic invasion are typical histopathological findings of IBC, shown in about 75% of all IBC cases. However, the etiology of this disease remains largely unknown and its diagnostic difficult to establish.Using single cell transcriptomics, we profiled a total of 10 patient-derived needle biopsies from IBC-hormone receptor (IBC-HR), IBC-triple negative breast cancer (IBC-TNBC), TNBC and HR subtypes, and one normal breast sample. After data QC, we obtained a total of 36,000 cells representing immune, epithelial and stromal cell populations. We performed analysis of the spatial cell distribution through a transcriptomics-informed panel using highly multiplex imaging mass cytometry (IMC) on FFPE section obtained from the same patients.While we noted interpatient heterogeneity within cancer cells in our single cell dataset, immune and stromal cells did show similarity across IBC patients. We identified differences across the myeloid compartment between IBC and non-IBC cells, specifically affecting the dendritic cell subpopulations.The interferon gamma pathway was specifically elevated in several cell types across IBC patients, and particularly in immune cells such as T and myeloid cells. We used MX1 as a marker of interferon gamma response as part of the IMC panel and confirmed this signature in IBC samples. There was no alpha and beta interferon transcriptomic signature in the single cells. Through IMC, we were able to identify the cellular composition surrounding the tumor microemboli. Contrary to what has been postulated in the literature, these cells are not lymphatic cells, but appear to be of fibroblastic origin and express the fibroblast marker CD90. As well, we detected a non-overlapping distribution of Collagen 1 positive and CD90 positive fibroblasts throughout the IBC specimens, revealing heterogeneity within the fibroblast population and its organization. Spatial immune cell analysis also revealed the presence of tertiary lymphoid structures in IBC tumors. Citation Format: Elise Courtois, William Flynn, Santhosh Sivajothi, Martine Seignon, Diane Luo, Bora Lim, Paul Robson. Spatially resolved cell type heterogeneity uncovers the distinct biology of inflammatory breast cancer [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P1-24-04.