tbuckley/cabot-search huggingface dataset:
Annals Graphic Medicine - Dr. Mom: My COVID Coping Mechanisms
Authors: Grace E. Farris
Journal: Annals of Internal Medicine (2020)

Web ExclusivesJanuary 2021Annals Graphic Medicine - Dr. Mom: My COVID Coping MechanismsFREEGrace E. Farris, MDGrace E. Farris, MDUniversity of Texas, Austin, Texas (G.E.F.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/G20-0117 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Panel 1 Download figure Download PowerPoint Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: University of Texas, Austin, Texas (G.E.F.)Disclosures: The author has disclosed no conflicts of interest. The form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=G18-0042.Author/Illustrator Information: Grace E. Farris, MD, is an assistant professor of medicine at Dell Medical School at the University of Texas in Austin, Texas. You can view her work at her website: www.farrisgrace.comAbout Dr. Mom: In Dr. Mom, physician and cartoonist Grace Farris examines work–life balance while mothering and doctoring. Dr. Mom appears monthly in Annals Graphic Medicine at Annals.org.This article was published at Annals.org on 22 December 2020. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics January 2021Volume 174, Issue 1Page: W1-W2 ePublished: 22 December 2020 Issue Published: January 2021 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Evaluation of Progress Toward Gender Equity Among Departmental Chairs in Academic Medicine
Authors: Bismarck C. Odei, Phylicia Gawu, Sonu Bae, Denise Fabian, James Odei, Clara Lee, Darrion Mitchell
Journal: JAMA Internal Medicine (2020)

Although the gender gap in medical school matriculation has closed, 1 the representation of women in leadership roles in academic medicine has been reported to be low, particularly among departmental chairs. 2 This study evaluates the extent of progress in female representation among program directors (PDs), chairs, and deans to provide a valuable benchmark by which to evaluate future progress.Methods | We obtained data on the gender of chairs, deans, and academic faculty from the Association of American Medical Colleges database 3 from January 1, 2010, through December 31, 2019, for a cross-sectional study.We also obtained data from 2019 on the gender of academic faculty 3 and chairs 3 in 14 of the largest medical specialties.Data on residents and PDs were obtained from the Accreditation Council for Graduate Medical Education; however, the gender of PDs was assigned by name and corresponding online photographs.Our study met Ohio State University Institutional Review Board policy for exemption.
Ultrafiltration in End-Stage Heart Failure: Too Little, Too Late?⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Authors: Larry A. Weinrauch, Akshay S. Desai, Eldrin F. Lewis, John A. D’Elia
Journal: Journal of the American College of Cardiology (2012)
A question of colour: systemic racism in sports and exercise medicine
Authors: Phathokuhle Cele Zondi, Ashley V Austin
Journal: British Journal of Sports Medicine (2020)

People often think of racism as aggressive and overt. However, more commonly it is subtle—intricately embedded into societal beliefs, expectations and practices. Systemic racism leads to the disproportionate distribution of resources, power and opportunities.1 2 It is ubiquitous, and exists in sports and exercise medicine (SEM) as it does in other industries. As two black SEM professionals, from different countries on different continents, it is our daily lived experience. We have had to sidestep racial slurs from patients; spar with employers over intentionally low-balled salary offers that devalue our talents; and hurdle perceptual barriers in the workplace just to be acknowledged as equals, despite occupying leadership positions. The ultimate challenge of playing in a sports medicine game that ignites us, within a system that often devalues us, is to use our efforts and voices to level the playing field for future generations.

The purpose of this editorial is to highlight distinct ways in which institutional racism manifests within SEM, and provide …
Genotype-Specific Differences in Circulating Tumor DNA Levels in Advanced NSCLC
Authors: Vincent K. Lam, Jianjun Zhang, Carol C. Wu, Hai T. Tran, Lerong Li, Lixia Diao, Jing Wang, Waree Rinsurongkawong, Victoria M. Raymond, Richard B. Lanman, Jeff Lewis, Emily B. Roarty, Jack Roth, Stephen Swisher, J. Jack Lee, Don L. Gibbons, Vassiliki A. Papadimitrakopoulou, John V. Heymach
Journal: Journal of Thoracic Oncology (2020)
Influence of inhalation device, active substance, and drug formulation on the compliance of patients with obstructive pulmonary diseases. A physicians... perspective
Authors: S.G. Theodorakis, G. Kolios, V. Tzilas, D. Bouros
Journal: Pulmonology (2020)

To investigate the perspective of physicians treating chronic airway diseases on the importance of device and substance characteristics influencing the compliance of patients with chronic obstructive airways diseases.We surveyed physicians... perspective on the impact of device and substance characteristics on patients... compliance.This study was carried out by running a structured questionnaire, to a total of 144 physicians, conducting personal interviews and evaluating answers on a scale from 1 for most to 6 for least important influencing parameter.Overall, the most important parameters influencing patients... compliance according to physicians... perspective were rapid onset of action, type of inhalation device and duration of action. Adverse events were considered as the least important parameter. When COPD and asthma were examined separately, the most important parameters influencing compliance were rapid onset of action, ease of use and duration of action. Rapid onset of action was significantly more important in asthma than COPD.Onset and duration of action and ease of use were classified higher as important parameters to increase patients... compliance, according to physicians...
Slow Low-Efficiency Dialysis (SLED) Implementation During the COVID-19 Pandemic Surge
Authors: Richard L. Barnett, Kenar D. Jhaveri, Bessy Suyin Flores Chang, Azzour D. Hazzan, Shamir Hasan, Steven Fishbane, Mark A. Finger
Journal: Journal of the American Society of Nephrology (2020)

Barnett, Richard L.; Jhaveri, Kenar D.; Chang, Bessy Suyin Flores; Hazzan, Azzour D.; Hasan, Shamir; Fishbane, Steven; Finger, Mark A. Author Information
Reply to the letter regarding the article ‘Efficacy and safety of tafamidis doses in the Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (<scp>ATTR‐ACT</scp>) and long‐term extension study’
Authors: Thibaud Damy, Marla B. Sultan, Ronald Witteles
Journal: European Journal of Heart Failure (2020)
Identifying Barriers to Implementing an Assisted Home Hemodialysis Program in Canada
Authors: Drew Hager, April Bertrand, Nickie L. Cool, Thomas W. Ferguson, Claudio Rigatto, Navdeep Tangri, Clara Bohm, Michelle S. DiNella, Paul Komenda
Journal: Journal of the American Society of Nephrology (2020)

Background: Policy changes such as the Advancing American Kidney Health Initiative and the impact of the COVID-19 pandemic will accelerate the trend for more home dialysis  Expanding the pool of patients eligible for HHD will require health care practitioner assisted models to be developed and deployed  We hypothesize that many barriers to delivering assisted HHD (aHHD) exist and implementation of a successful program would require meaningful input from frontline home dialysis nurses  Our primary objective of this study is to survey these key stakeholders to identify these barriers  Methods: We conducted a semi-structured focus group of leaders within our large Canadian home dialysis program to anticipate key aspects of implementing aHHD, including gauging local demand, identifying eligible patients, and recognizing essential operational components  From this, we constructed questionnaires for frontline nursing staff within HHD, peritoneal dialysis (PD) and assisted PD (aPD) programs  We performed a qualitative analysis to identify common themes and implementation barriers  Results: Twenty-six responses from three sites were received  20/21 PD nurses reported existing aPD programs expanded the eligible pool of PD patients  5/5 HHD nurses felt an aHHD program would keep more patients on the modality and prevent technique failure  Only 2/5 felt aHHD should be offered as a transition to HHD  While 18/21 PD nurses reported they could easily identify patients for aPD, only 2/5 HHD nurses agreed  Patients with sensory deficits, functional impairments, and limited support networks were felt to benefit most from aHHD  Lack of confidence and phobias were not agreed upon  Behavioral and safety issues, clinical instability, and inability to manage emergencies may be barriers to aHHD  Machine set-up, take-down, and establishing access were thought to be essential services  PD nurses felt clinical assessments should be routine  Few nurses felt complete assistance was necessary  Conclusions: Our findings suggest there is a strong local demand for aHHD provided there is a clear criterion for enrollment and operational plans are well established  Frontline nurses have identified several important barriers to implementation which we will acknowledge and address when deploying our assisted home program over the upcoming year
Portuguese adaptation of the S3-non-invasive ventilation (S3-NIV) questionnaire for home mechanically ventilated patients
Authors: C. Ribeiro, S. Conde, P. Oliveira, C. Nogueira, D. Ferreira, D. Adler, W. Windisch, R. Nunes
Journal: Pulmonology (2020)

Short, valid and easy to use tools are needed to monitor non-invasive ventilation in clinical practice and for organization of home mechanical ventilation services. The aim of this study was to develop a professional translation and cultural adaptation of the Portuguese S3 non-invasive ventilation questionnaire. 234 stable patients (128 male patients, 53.8%) with a mean age of 69.3 years under long-term home non-invasive ventilation were recruited from a single-center outpatient clinic. The most frequent diagnostic groups were obesity hypoventilation syndrome, chronic obstructive pulmonary disease and restrictive chest wall disorders. The Portuguese version of the questionnaire was obtained using translation back-translation process with two professional translators. Internal consistency for the total score was good (Cronbach's α coefficient of 0.76) as well as for the "respiratory symptoms" and the "sleep and side effects" domains (Cronbach's α coefficient=0.68 and Cronbach's α coefficient=0.72, respectively). An exploratory factor analysis was performed leading to an explained variance of 54.6%, and resulted in 3 components. The Portuguese version of the S3-NIV questionnaire is a simple and valid tool for the routine clinical assessment of patients receiving home NIV.
Abstract 17400: Lipoprotein(a) is a Determinant of Residual Cardiovascular Risk in the Setting of Optimal LDL-C in Statin-Treated Patients With Atherosclerotic Cardiovascular Disease
Authors: Giacomo Ruotolo, Michael A Lincoff, Venu Menon, Ellen McErlean, Kathy Wolski, Joseph V Haas, Govinda Weerakkody, Jeffrey S Riesmeyer, Steven E Nissen, Stephen J Nicholls
Journal: Circulation (2017)

Background: Elevated lipoprotein(a) [Lp(a)] levels have been shown to be an independent risk factor for atherosclerotic cardiovascular disease (ASCVD), but it is unclear if they are a determinant o...
Ensuring the Equitable Advancement of American Kidney Health—the Need to Account for Socioeconomic Disparities in the ESRD Treatment Choices Model
Authors: Yuvaram N.V. Reddy, Sri Lekha Tummalapalli, Mallika L. Mendu
Journal: Journal of the American Society of Nephrology (2020)

The finalized ESRD Treatment Choices (ETC) payment model was announced by the Centers for Medicare & Medicaid Services (CMS) on September 18, 2020.[1][1] Recognizing the underutilization of home dialysis and kidney transplantation, CMS introduced the ETC model as part of the Advancing American
Corrigendum to “Enhancement and orchestration of osteogenesis and angiogenesis by a dual-modular design of growth factors delivery scaffolds and 26SCS decoration” [Biomaterials 232 (2020) 119645]
Authors: Wei Tang, Yuanman Yu, Jing Wang, Hui Liu, Haobo Pan, Guocheng Wang, Changsheng Liu
Journal: Biomaterials (2020)
Effect of Autologous Hematopoietic Stem Cell Transplant (aHSCT) on the Development of Second Primary Malignancies (SPM) in Multiple Myeloma Patients
Authors: Aaron Seth Rosenberg, Ann M Brunson, Joseph M Tuscano, Brian A Jonas, Mehrdad Abedi, Ted Wun, Theresa H.M. Keegan
Journal: Blood (2017)
Health and economic impact of air pollution in the states of India: the Global Burden of Disease Study 2019
Authors: Anamika Pandey, Michael Brauer, Maureen L Cropper, Kalpana Balakrishnan, Prashant Mathur, Sagnik Dey, Burak Turkgulu, G Anil Kumar, Mukesh Khare, Gufran Beig, Tarun Gupta, Rinu P Krishnankutty, Kate Causey, Aaron J Cohen, Stuti Bhargava, Ashutosh N Aggarwal, Anurag Agrawal, Shally Awasthi, Fiona Bennitt, Sadhana Bhagwat, P Bhanumati, Katrin Burkart, Joy K Chakma, Thomas C Chiles, Sourangsu Chowdhury, D J Christopher, Subhojit Dey, Samantha Fisher, Barbara Fraumeni, Richard Fuller, Aloke G Ghoshal, Mahaveer J Golechha, Prakash C Gupta, Rachita Gupta, Rajeev Gupta, Shreekant Gupta, Sarath Guttikunda, David Hanrahan, Sivadasanpillai Harikrishnan, Panniyammakal Jeemon, Tushar K Joshi, Rajni Kant, Surya Kant, Tanvir Kaur, Parvaiz A Koul, Praveen Kumar, Rakesh Kumar, Samantha L Larson, Rakesh Lodha, Kishore K Madhipatla, P A Mahesh, Ridhima Malhotra, Shunsuke Managi, Keith Martin, Matthews Mathai, Joseph L Mathew, Ravi Mehrotra, B V Murali Mohan, Viswananthan Mohan, Satinath Mukhopadhyay, Parul Mutreja, Nitish Naik, Sanjeev Nair, Jeyaraj D Pandian, Pallavi Pant, Arokiasamy Perianayagam, Dorairaj Prabhakaran, Poornima Prabhakaran, Goura K Rath, Shamika Ravi, Ambuj Roy, Yogesh D Sabde, Sundeep Salvi, Sankar Sambandam, Bhavay Sharma, Meenakshi Sharma, Shweta Sharma, R S Sharma, Aakash Shrivastava, Sujeet Singh, Virendra Singh, Rodney Smith, Jeffrey D Stanaway, Gabrielle Taghian, Nikhil Tandon, J S Thakur, Nihal J Thomas, G S Toteja, Chris M Varghese, Chandra Venkataraman, Krishnan N Venugopal, Katherine D Walker, Alexandrea Y Watson, Sarah Wozniak, Denis Xavier, Gautam N Yadama, Geetika Yadav, D K Shukla, Hendrik J Bekedam, K Srinath Reddy, Randeep Guleria, Theo Vos, Stephen S Lim, Rakhi Dandona, Sunil Kumar, Pushpam Kumar, Philip J Landrigan, Lalit Dandona
Journal: The Lancet Planetary Health (2020)

The association of air pollution with multiple adverse health outcomes is becoming well established, but its negative economic impact is less well appreciated. It is important to elucidate this impact for the states of India.
Antidiabetic Effects of Gegen Qinlian Decoction via the Gut Microbiota are Attributable to Its Key Ingredient Berberine
Authors: Xizhan Xu, Zezheng Gao, Fuquan Yang, Yingying Yang, Liang Chen, Lin Han, Na Zhao, Jiayue Xu, Xinmiao Wang, Yue Ma, Lian Shu, Xiaoxi Hu, Na Lyu, Yuanlong Pan, Baoli Zhu, Linhua Zhao, Xiaolin Tong, Jun Wang
Journal: Genomics Proteomics & Bioinformatics (2020)

Abstract Gegen Qinlian Decoction (GQD), a traditional Chinese medicine (TCM) formula, has long been used for the treatment of common metabolic diseases, including type 2 diabetes mellitus. However, the main limitation of its wider application is ingredient complexity of this formula. Thus, it is critically important to identify the major active ingredients of GQD and to illustrate mechanisms underlying its action. Here, we compared the effects of GQD and berberine, a hypothetical key active pharmaceutical ingredient of GQD, on a diabetic rat model by comprehensive analyses of gut microbiota, short-chain fatty acids, proinflammatory cytokines, and ileum transcriptomics. Our results show that berberine and GQD had similar effects on lowering blood glucose levels, modulating gut microbiota, inducing ileal gene expression, as well as relieving systemic and local inflammation. As expected, both berberine and GQD treatment significantly altered the overall gut microbiota structure and enriched many butyrate-producing bacteria, including Faecalibacterium and Roseburia, thereby attenuating intestinal inflammation and lowering glucose. Levels of short-chain fatty acids in rat feces were also significantly elevated after treatment with berberine or GQD. Moreover, concentration of serum proinflammatory cytokines and expression of immune-related genes, including Nfkb1, Stat1, and Ifnrg1, in pancreatic islets were significantly reduced after treatment. Our study demonstrates that the main effects of GQD can be attributed to berberine via modulating gut microbiota. The strategy employed would facilitate further standardization and widespread application of TCM in many diseases.
Changes in Use of Radiotherapy Among Dermatologists From 2013 to 2017
Authors: Khang D. Nguyen, Henry W. Chen, Adewole S. Adamson
Journal: JAMA Dermatology (2020)

Concerns have been raised about the use of radiotherapy (RT) by dermatologists. Little is known about temporal trends in payment for RT among dermatologists.To characterize changes in RT use and payment among dermatologists treating patients enrolled in Medicare.A cross-sectional, population-based retrospective analysis of dermatologists submitting Medicare claims was conducted. Dermatologists identified in the 2013-2017 Medicare Physician and Other Supplier Public Use File, which includes information on fee-for-service payments and service use among physicians caring for Medicare beneficiaries, were included in the analysis. The study was conducted from March 18 to October 22, 2020.Numbers and types of RT, current terminology codes billed by dermatologists, number of dermatologists providing RT services, total payments and median payments per dermatologist for RT services, total services and median services per dermatologist, and number of dermatologists billing for both RT and Mohs micrographic surgery services.From 2013 to 2017, dermatologists billed RT codes, which included RT planning, preparation, delivery, and management services with varying levels of complexity. The number of dermatologists using RT increased from 115 to 198 between 2013 to 2017. Total payments and total services for RT have fluctuated over time. Median payments per dermatologist and median services provided per dermatologist for RT reached their highest level in 2017 ($80 810 and 629 services). In 2013, RT delivery was the highest reimbursed RT service type (total paid, $9 121 505). By 2017, clinical treatment planning and simulation was the highest reimbursed service type (total paid, $20 288 796).The findings of this cross-sectional study indicate that dermatologist use of RT continues to increase. A wide variety of RT services are billed by dermatologists. Further research is needed to ensure expanded use is safe, efficacious, and cost-effective.
Correspondence on ‘Machine learning algorithms reveal unique gene expression profiles in muscle biopsies from patients with different types of myositis’
Authors: Satoshi Takanashi
Journal: Annals of the Rheumatic Diseases (2020)

I read the paper by Pinal-Fernandez et al in your journal with great interest.1 They reported that machine algorithms can be trained on transcriptomic data to classify muscle biopsies from patients with various idiopathic inflammatory myopathies (IIM). I think this classification model can be applied to personalised medicine by targeting the specific molecules. Here, I would ask the questions and comments to clarify the further usefulness of this study and development of IIM management in the future.

First, how many patients with IIM had interstitial lung disease (ILD) and was there any discrepancy …
Risk stratification for proton pump inhibitor-associated type 2 diabetes: a population-based cohort study
Authors: Qiangsheng He, Man Yang, Xiwen Qin, Die Fan, Jinqiu Yuan, Yihang Pan
Journal: Gut (2020)

We have recently reported in GUT that regular proton pump inhibitor (PPI) use was associated with a 24% increased risk of type 2 diabetes mellitus (T2DM).1 This was the first study demonstrating an association between PPIs and diabetes. However, all included participants were healthcare professionals and the findings have not been verified in general populations. Additionally, investigation of subgroups at high absolute risk of diabetes among PPI users is still lacking. Because the absolute effects of interventions tend to increase with baseline risk, individualised treatment based on the patients’ underlying risk may confer benefits and reduce harms. Such risk stratification strategy had been applied to select patients for antihypertensive and statin therapy.2 3 In the present study, we conducted a prospective analysis of the UK-Biobank to (1)confirm the association between PPI use and T2DM in general population and (2) to investigate which population groups may have high net risk.

We included participants free of diabetes from the UK Biobank.4 Regular use of PPIs was defined as taking PPIs in most days of week for the last 4 weeks. T2DM cases were identified from different data sources (primary care, hospital admissions, self-report and death register). We evaluated hazard ratios (HRs) adjusting for potential confounders. We calculated …
The Devastating Legacy of Breast Cancer Death in Sub-Saharan Africa—Maternal Orphans and a Cycle of Disadvantage
Authors: Mediget Teshome, Mariana Chavez-MacGregor
Journal: JAMA Oncology (2020)

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