tbuckley/cabot-search huggingface dataset:
Abstract 2803: Multiple Biomarkers For The Prediction Of Cardiac Events In Chronic Heart Failure Patients
Authors: Takeshi Niizeki, Yasuchika Takeishi, Yo Koyama, Tatsuro Kitahara, Satoshi Suzuki, Isao Kubota
Journal: Circulation (2007)

Backgrounds: Chronic heart failure (CHF) still represents the major cause of death and hospitalization. Although there is substantial interest in the use of newer biomarkers to identify CHF patients (risk assessment and prevention for cardiac events) recently, few investigations have evaluated the incremental usefulness of combination of multiple biomarkers. Measurement of several biomarkers simultaneously could enhance risk stratification. We therefore evaluated the usefulness of 7 known biomarkers for predicting cardiac events. Methods and Results: We analyzed 7 biomarkers (BNP, uric acid, Na, hemoglobin, creatinine, creatinine clearance, high sensitive CRP) which are known as established prognostic markers for CHF in consecutive 399 CHF patients. When there was an abnormal value, we scored it for one point to calculate multimarker score. Patients were categorized tertiles according to multimarker score. Patients with the high tertile were older and had more severe NYHA class and lower ejection fraction than those with low and intermediate tertiles. There were 135 cardiac events including cardiac deaths and readmissions for worsening CHF during follow-up period. A Cox proportional hazard model showed that patients with high tertile were associated with the highest risk of cardiac events compared with other two tertiles (Figure A ). Kaplan-Meier analysis revealed that tertile analysis effectively risk stratified CHF patients for cardiac events (Figure B ). Conclusions: These findings suggest that the combination of the multi-biomarkers could potentially improve the risk stratification of CHF patiens for the prediction of cardiac events.
A substantia innominata-midbrain circuit controls a general aggressive response
Authors: Zhenggang Zhu, Qingqing Ma, Lu Miao, Hongbin Yang, Lina Pan, Kaiyuan Li, Ling-Hui Zeng, Xiaoxing Zhang, Jintao Wu, Sijia Hao, Shen Lin, Xiulin Ma, Weihao Mai, Xiang Feng, Yizhe Hao, Li Sun, Shumin Duan, Yan-qin Yu
Journal: Neuron (2021)

Although aggressive behaviors are universal and essential for survival, "uncontrollable" and abnormal aggressive behaviors in animals or humans may have severe adverse consequences or social costs. Neural circuits regulating specific forms of aggression under defined conditions have been described, but how brain circuits govern a general aggressive response remains unknown. Here, we found that posterior substantia innominata (pSI) neurons responded to several aggression-provoking cues with the graded activity of differential dynamics, predicting the aggressive state and the topography of aggression in mice. Activation of pSI neurons projecting to the periaqueductal gray (PAG) increased aggressive arousal and robustly initiated/promoted all the types of aggressive behavior examined in an activity-level-dependent manner. Inactivation of the pSI circuit largely blocked diverse aggressive behaviors but not mating. By encoding a general aggressive response, the pSI-PAG circuit universally drives multiple aggressive behaviors and may provide a potential target for alleviating human pathological aggression.
Inferring the Genetic Basis of Sex Determination from the Genome of a Dioecious Nightshade
Authors: Meng Wu, David C Haak, Gregory J Anderson, Matthew W Hahn, Leonie C Moyle, Rafael F Guerrero
Journal: Molecular Biology and Evolution (2021)

Abstract Dissecting the genetic mechanisms underlying dioecy (i.e., separate female and male individuals) is critical for understanding the evolution of this pervasive reproductive strategy. Nonetheless, the genetic basis of sex determination remains unclear in many cases, especially in systems where dioecy has arisen recently. Within the economically important plant genus Solanum (∼2,000 species), dioecy is thought to have evolved independently at least 4 times across roughly 20 species. Here, we generate the first genome sequence of a dioecious Solanum and use it to ascertain the genetic basis of sex determination in this species. We de novo assembled and annotated the genome of Solanum appendiculatum (assembly size: ∼750 Mb scaffold N50: 0.92 Mb; ∼35,000 genes), identified sex-specific sequences and their locations in the genome, and inferred that males in this species are the heterogametic sex. We also analyzed gene expression patterns in floral tissues of males and females, finding approximately 100 genes that are differentially expressed between the sexes. These analyses, together with observed patterns of gene-family evolution specific to S. appendiculatum, consistently implicate a suite of genes from the regulatory network controlling pectin degradation and modification in the expression of sex. Furthermore, the genome of a species with a relatively young sex-determination system provides the foundational resources for future studies on the independent evolution of dioecy in this clade.
A Systematic Review of Monogenic Inflammatory Bowel Disease
Authors: Ryusuke Nambu, Neil Warner, Daniel J. Mulder, Daniel Kotlarz, Dermot P.B. McGovern, Judy Cho, Christoph Klein, Scott B. Snapper, Anne M. Griffiths, Itaru Iwama, Aleixo M. Muise
Journal: Clinical Gastroenterology and Hepatology (2021)

Advances in genomic technologies have led to increasing reports of monogenic inflammatory bowel disease (IBD). Here, we systematically review the literature to determine the clinical features, genetic profile, and previously used treatment strategies in monogenic IBD.A systematic review of MEDLINE articles published between January 2000 and December 2020 was conducted. A total of 750 individual monogenic IBD cases were identified from 303 eligible articles.The most frequently reported monogenic IBD genes were IL10RA/B, XIAP, CYBB, LRBA, and TTC7A. In total, 63.4% of patients developed IBD before 6 years of age, 17.4% developed IBD between ages 10 and 17.9 years, and 10.9% developed IBD after age 18. There was a substantial difference between these age groups and the underlying monogenic disorders. Only 31.7% had any history of extraintestinal comorbidity (EIC) before IBD onset, but 76.0% developed at least 1 EIC during their clinical course. The most common EICs were atypical infection (44.7%), dermatologic abnormality (38.4%), and autoimmunity (21.9%). Bowel surgery, biologic therapy, and hematopoietic stem cell transplantation were performed in 27.1%, 32.9%, and 23.1% of patients, respectively.Monogenic IBD cases, although rare, have varied extraintestinal comorbidities and limited treatment options including surgery and transplant. Early identification and improved understanding of the characteristics of the genes and underlying disease processes in monogenic IBD is important for effective management.
P09.15 Severity of Lung Cancer Disease in Hospitalized Patients During COVID-19
Authors: L. Fernández-Mañas, T. Gorría, E. Auclin, R. Reyes, C. Teixidó, J. Marco-Hernández, J. Padrosa, M. García De Herreros, D. Pesántez, D. Martínez, M. Mollà, I. Vollmer, R. Marrades, A. Guirao, A. Prat, N. Viñolas, L. Mezquita, N. Reguart
Journal: Journal of Thoracic Oncology (2021)
HSR21-060: Real-World Treatment Patterns After Trastuzumab-Based Regimen in Patients With HER2-Positive Metastatic Gastric Cancer in the United States
Authors: Feng Lin, Jinlin Song, Melissa Pavilack, Jipan Xie, Catherine Fernan, Ahmed Noman, Winghan Jacqueline Kwong
Journal: Journal of the National Comprehensive Cancer Network (2021)

"HSR21-060: Real-World Treatment Patterns After Trastuzumab-Based Regimen in Patients With HER2-Positive Metastatic Gastric Cancer in the United States" published on 17 Mar 2021 by National Comprehensive Cancer Network.
FP09.05 Driver Oncogenic Alterations and Indoor Radon in NSCLC Patients From the IFCT Biomarker Cohort: Bioradon France Study
Authors: L. Mezquita, F. Barlesi, G. Ielsch, J. Merlio, D. Debieuvre, J. Mosser, C. Ricordel, L. Ouafik, I. Rouquette, I. Monnet, F. Escande, A. Langlais, F. Morin, C. Vignaud, E. Auclin, J.C. Benitez, D. Planchard, K. Leuraud, D. Laurier, B. Besse, V. Westeel
Journal: Journal of Thoracic Oncology (2021)
P75.12 Prognostic Value of Neutrophil to Lymphocyte Ratio in NSCLC Patients Receiving First Line Immune Checkpoint Inhibitor Therapy
Authors: N. Surya, M. Li, S. Zhao, L. Wei, S. Patel, G. Lopez, A. Johns, M. Grogan, E. Bertino, K. He, P. Shields, D. Carbone, G. Otterson, C. Presley, D. Owen
Journal: Journal of Thoracic Oncology (2021)
P76.19 Clinical Outcomes of Lung Cancer Patients Who Acquired EGFR T790M/in trans-C797S Mutations After Resistance to Osimertinib
Authors: C. Lu, Z. Zhou, D. Zheng, Y. He, Y. Li, Z. Wang, W. Zhong, X. Zhang, Y. Wu, Q. Zhou
Journal: Journal of Thoracic Oncology (2021)
<i>JAMA Pediatrics</i>—The Year in Review, 2020
Authors: Dimitri A. Christakis
Journal: JAMA Pediatrics (2021)

For the last 3 years, I have begun this review by stating it has been an extraordinary year for JAMA Pediatrics.I mean it this time!The calendar year coincides almost perfectly with the start of the coronavirus disease 2019 (COVID-19) pandemic, and for all of the misery it brought, it also generated an enormous amount of research.We received more than 1000 COVID-19-related manuscripts from all over the world.In part because of these, our overall submissions were up 53%, and our acceptance rate for the year was 5% (down from 8% last year).In 2020, the top-viewed articles were all related to COVID-19, 1-3 as were 2 of the top 3 ar-ticles by Altmetric score (a measure of news and social media attention) 1,3,4 and the top 3 most cited articles. 2,3,5 There remain unanswered questions related to COVID-19, and we are seeking manuscripts that address those.And in the pandemic's anticipated wake, we expect many articles that continue to demonstrate what the long-term effects will be on children as they slowly return to some sense of normalcy.JAMA Pediatrics continues to be the preeminent pediatric journal in the world as evidenced by the impact factor, which is now 13.97.In addition, articles published in JAMA Pediatrics received more than 8.1 million views and 32 000 mentions in the news media (Table ).These metrics are Table.
P30.09 Exposure to Antibiotics May Affect Progression-Free Survival Negatively in NSCLC Patients Receiving First-Line Chemotherapy
Authors: X. Tian, Y. Gong, T. Mei, X. Yang, Y. Xu, M. Yu, Y. Li, J. Zhu, M. Huang, Y. Zhang, F. Peng, L. Zhou, X. Zhou, J. Xue, Y. Liu, B. Zou, Y. Wang, Y. Lu
Journal: Journal of Thoracic Oncology (2021)
Abstract 15888: Outcomes of Surgical Intervention for Acute Type A Aortic Dissection in Octogenarians - Insights From the International Registry of Acute Aortic Dissection (IRAD)
Authors: Stevan S Pupovac, Jonathan Hemli, Thomas G Gleason, Thoralf M Sundt, Nimesh D Desai, Davide Pacini, Maral Ouzounian, Jehangir J Appoo, Daniel G Montgomery, Kim Eagle, Takeyoshi Ota, Marco Di Eusanio, Anthony L Estrera, Joseph S Coselli, Himanshu J Patel, Santi Trimarchi, Derek R Brinster
Journal: Circulation (2019)

Introduction: The aging population, coupled with improvements in life expectancy, is associated with an increasing incidence of type A acute aortic dissection (TAAAD) in the elderly. Hypothesis: Su...
Effective Intratumoral Retention of [<sup>103</sup>Pd]AuPd Alloy Nanoparticles Embedded in Gel‐Forming Liquids Paves the Way for New Nanobrachytherapy
Authors: Matthias Fach, Frederikke P. Fliedner, Paul J. Kempen, Fredrik Melander, Anders E. Hansen, Linda M. Bruun, Ulli Köster, Emanuel Sporer, Andreas Kjær, Thomas L. Andresen, Andreas I. Jensen, Jonas R. Henriksen
Journal: Advanced Healthcare Materials (2021)

Abstract Local application of radioactive sources as brachytherapy is well established in oncology. This treatment is highly invasive however, due to the insertion of millimeter sized metal seeds. The authors report the development of a new concept for brachytherapy, based on gold‐palladium (AuPd) alloy nanoparticles, intrinsically radiolabeled with 103 Pd. These are formulated in a carbohydrate‐ester based liquid, capable of forming biodegradable gel‐like implants upon injection. This allows for less invasive administration through small‐gauge needles. [ 103 Pd]AuPd nanoparticles with sizes around 20 nm are prepared with radiolabeling efficiencies ranging from 79% to &gt;99%. Coating with the hydrophobic polymer poly(N‐isopropylacrylamide) leads to nanoparticle diameters below 40 nm. Dispersing the nanoparticles in ethanol with water insoluble carbohydrate esters gives “nanogels”, a low viscosity liquid capable of solidifying upon injection into aqueous environments. Both nanoparticles and radioactivity are stably retained in the nanogel over 25 days (&gt;99%) after formation in aqueous buffers. Animals bearing CT26 murine tumors are injected intratumorally with 25 MBq of the 103 Pd‐nanogel, and display tumor growth delay and significantly increase median survival times compared with control groups. Excellent retention in the tumor of both the 103 Pd and the nanoparticle matrix itself is observed, demonstrating a potential for replacing currently used brachytherapy seeds.
N-Myristoyltransferase 2 (NMT2) Protein Levels Predict Survival in Acute Myeloid Leukemia (AML): A Novel Prognostic Biomarker
Authors: Ryan J Stubbins, Zoulika Zak, Aishwarya Iyer, Megan Yap, Krista Vincent, Lynne M Postovit, John R Mackey, Artur J Szkotak, Lalit Saini, Luc G Berthiaume, Joseph M. Brandwein
Journal: Blood (2017)
FP05.02 An Early Detection and Prognostic Blood Biomarkers Signature for Malignant Pleural Mesothelioma Based on Targeted Proteomics
Authors: F. Cerciello, M. Choi, S. Sinicropi-Yao, K. Lomeo, J. Amann, E. Felley-Bosco, R. Stahel, U. Wa, J. Creaney, H. Pass, O. Vitek, D. Carbone
Journal: Journal of Thoracic Oncology (2021)
The AMP Trials — A Glass Half Full
Authors: Bruce D. Walker
Journal: New England Journal of Medicine (2021)

Induction of broadly neutralizing antibodies (bnAbs) is considered the holy grail for a preventive human immunodeficiency virus (HIV) vaccine, but four decades into the HIV pandemic, this goal has still not been achieved. Success will probably require multiple sequential immunogens to guide the affinity maturation needed for the induction of antibodies that can target well-concealed neutralization epitopes on the heavily glycosylated, highly variable HIV envelope protein1 — a formidable task. In contrast, in some persons with HIV infection, nature has achieved what vaccines have not: the gradual generation of potent bnAbs that have been cloned and have shown antiviral efficacy . . .
Longevity medicine: upskilling the physicians of tomorrow
Authors: Evelyne Bischof, Morten Scheibye-Knudsen, Richard Siow, Alexey Moskalev
Journal: The Lancet Healthy Longevity (2021)

Longevity medicine is advanced personalised preventive medicine powered by deep biomarkers of aging and longevity, and is a fast-emerging field. The field encompasses the likewise rapidly evolving areas of biogerontology, geroscience, and precision, preventive, and functional medicine.
MA08.04 LIPI and outcomes of durvalumab as consolidation therapy after ChRT in patients with locally-advanced NSCLC
Authors: M. Riudavets, L. Mezquita, E. Auclin, J.C. Benitez, C. Le Pechoux, M. Majem, N. Dempsey, R. Lobefaro, E. Nadal, A. Amores, J. Menis, M. Tagliamento, R. López-Castro, S. Ponce, J. Bosch-Barrera, F. Aboubakar, J. Mosquera, S. Pilotto, R. Reyes, X. Mielgo, B. Duchemann, M. Mosteiro, E. Mussat, A. De Giglio, M. Scheffler, M. Campayo, A. Botticella, C. Naltet, P. Lavaud, G. Lopes, D. Signorelli, R. Garcia-Campelo, B. Besse, D. Planchard
Journal: Journal of Thoracic Oncology (2021)
P62.04 Metabolic Profile of Urine of Early Stage Non Small Cell Lung Cancer Patients Before and After Surgical Resection Using Mass Spectrometry
Authors: N. Ahmed, B. Kidane, L. Wang, N. Moldovan, Z. Nugent, G. Qing, L. Tan, G. Buduhan, S. Srinathan, M. Aliani
Journal: Journal of Thoracic Oncology (2021)
MicroRNA-10 negatively regulates inflammation in diabetic kidney via targeting activation of the NLRP3 inflammasome
Authors: Hanying Ding, Jinxiang Li, Yang Li, Minliang Yang, Sheng Nie, Miaomiao Zhou, Zhanmei Zhou, Xiaobing Yang, Youhua Liu, Fan Fan Hou
Journal: Molecular Therapy (2021)

NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome activation has emerged as a central mediator of kidney inflammation in diabetic kidney disease (DKD). However, the mechanism underlying this activation in DKD remains poorly defined. In this study, we found that kidney-enriched microRNA-10a and -10b (miR-10a/b), predominantly expressed in podocytes and tubular epithelial cells, were downregulated in kidney from diabetic mice and patients with DKD. High glucose decreased miR-10a/b expression in vitro in an osmolarity-independent manner. miR-10a/b functioned as negative regulators of the NLRP3 inflammasome through targeting the 3′untranslated region of NLRP3 mRNA, inhibiting assembly of the NLRP3 inflammasome and decreasing caspase-1-dependent release of pro-inflammatory cytokines. Delivery of miR-10a/b into kidney prevented NLRP3 inflammasome activation and renal inflammation, and it reduced albuminuria in streptozotocin (STZ)-treated mice, whereas knocking down miR-10a/b increased NLRP3 inflammasome activation. Restoration of miR-10a/b expression in established DKD ameliorated kidney inflammation and mitigated albuminuria in both db/db and STZ-treated mice. These results suggest a novel intervention strategy for inhibiting kidney inflammation in DKD by targeting the NLRP3 inflammasome. NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome activation has emerged as a central mediator of kidney inflammation in diabetic kidney disease (DKD). However, the mechanism underlying this activation in DKD remains poorly defined. In this study, we found that kidney-enriched microRNA-10a and -10b (miR-10a/b), predominantly expressed in podocytes and tubular epithelial cells, were downregulated in kidney from diabetic mice and patients with DKD. High glucose decreased miR-10a/b expression in vitro in an osmolarity-independent manner. miR-10a/b functioned as negative regulators of the NLRP3 inflammasome through targeting the 3′untranslated region of NLRP3 mRNA, inhibiting assembly of the NLRP3 inflammasome and decreasing caspase-1-dependent release of pro-inflammatory cytokines. Delivery of miR-10a/b into kidney prevented NLRP3 inflammasome activation and renal inflammation, and it reduced albuminuria in streptozotocin (STZ)-treated mice, whereas knocking down miR-10a/b increased NLRP3 inflammasome activation. Restoration of miR-10a/b expression in established DKD ameliorated kidney inflammation and mitigated albuminuria in both db/db and STZ-treated mice. These results suggest a novel intervention strategy for inhibiting kidney inflammation in DKD by targeting the NLRP3 inflammasome.
Tumor Necrosis Factor α–Induced Protein 8–Like 2 Alleviates Nonalcoholic Fatty Liver Disease Through Suppressing Transforming Growth Factor Beta–Activated Kinase 1 Activation
Authors: Yupeng Liu, Jingjing Song, Juan Yang, Jilin Zheng, Ling Yang, Jun Gao, Song Tian, Zhen Liu, Xiangbin Meng, Jian‐Cheng Wang, Zhifei Dai, Yi‐Da Tang
Journal: Hepatology (2021)

Background and Aims NAFLD prevalence has increased rapidly and become a major global health problem. Tumor necrosis factor α–induced protein 8–like 2 (TIPE2) plays a protective role in a cluster of liver diseases, such as autoimmune hepatitis, hepatitis B, and hepatocellular carcinoma. However, the function of TIPE2 in NAFLD remains unknown. Here, we investigated the role of TIPE2 in the development of NAFLD. Approach and Results Our study found that in vitro overexpression or knockout of TIPE2 significantly ameliorated or aggravated lipid accumulation and inflammation in hepatocytes exposed to metabolic stimulation, respectively. Consistently, in vivo hepatic steatosis, insulin resistance, inflammation, and fibrosis were alleviated in hepatic Tipe2 ‐transgenic mice but exaggerated in hepatic Tipe2 ‐knockout mice treated by metabolic challenges. RNA sequencing revealed that TIPE2 was significantly associated with the mitogen‐activated protein kinase pathway. Mechanistic experiments demonstrated that TIPE2 bound with transforming growth factor beta–activated kinase 1 (TAK1), prevented tumor necrosis factor receptor–associated factor 6–mediated TAK1 ubiquitination and subsequently inhibited the TAK1 phosphorylation and activation of TAK1–c‐Jun N‐terminal kinase (JNK)/p38 signaling. Further investigation showed that blocking the activity of TAK1 reversed the worsening of hepatic metabolic disorders and inflammation in hepatic‐specific Tipe2 ‐knockout hepatocytes and mice treated with metabolic stimulation. Conclusions TIPE2 suppresses NAFLD advancement by blocking TAK1‐JNK/p38 pathway and is a promising target molecule for NAFLD therapy.
<i>JAMA Surgery</i>—The Year in Review, 2020
Authors: Melina R. Kibbe
Journal: JAMA Surgery (2021)

was a year associated with tremendous accomplishments for JAMA Surgery as well as notable challenges.First, as evidence of the high-quality scientific publications in JAMA Surgery, the impact factor rose from 10.7 to 13.6.This remarkable achievement reflects the hard work of our authors, peer reviewers, 1 and editorial team.The impact factor along with other important metrics positions JAMA Surgery as the number 1 ranked surgery journal in the world.In 2020, the acceptance rate for all article types was 12.6%; for Original Investigations, 4.3%; and for Research Letters, 9.7%.][4][5][6][7][8] The web and social media presence for JAMA Surgery continues to be very strong under the leadership of Amalia L. Cochran, MD, the Web and Social Media Editor.More than 5.1 million articles were viewed and downloaded from the journal website in 2020.The journal's electronic table of contents is delivered each week to more than 93 000 individuals.We currently have 37 157 Twitter followers, which represents a 20.2% increase in 2020, and 26 926 Facebook followers, which represents a 4.8% increase in 2020 (Table).Thus, between the electronic table of contents, visits to the journal website, social media reach, and print distribution, JAMA Surgery reaches more than 100 000 individuals weekly.JAMA Surgery continues to promote the work of the authors through additional outlets.JAMA Surgery publishes author interview podcasts each month.These podcasts continue to be stimulating under the direction of Dr Cochran, who brings a wonderful level of insight into the interview process with the authors.Articles published in JAMA Surgery had extensive press coverage, with 4552 media mentions in 2020 in outlets such as The New York Times, Wall Street Journal, USA Today, CNN, NPR, and Forbes.In recognition of the press coverage, web, and social media support, articles in JAMA Surgery have done well with Altmetric scores.JAMA Surgery published 9 of the top 10 articles by Altmetric score among surgery journals and 27 of the top 50 articles.In 2020, the journal also appreciated other changes, many of which were related to the coronavirus disease 2019 (COVID-19) pandemic.Manuscript submissions to JAMA Surgery sharply increased after the start of the pandemic.In total, JAMA Surgery received 3497 submissions in 2020, representing a 54% increase compared with 2019.A comparison of monthly submissions reveals that
Precut esophageal endoscopic mucosal resection for cervical esophageal cancer to minimize mucosal defect
Authors: Reona Kawamura, Seiichiro Abe, Mai Ego, Haruhisa Suzuki, Shigetaka Yoshinaga, Ichiro Oda, Yutaka Saito
Journal: Endoscopy (2021)

A 72-year-old man underwent esophagogastroduodenoscopy (EGD) for heartburn. Two adjacent, iodine-unstained, shallow depressed lesions, 25 mm and 8 mm in size, were found in the cervical esophagus ([Fig. 1]). Biopsies revealed squamous cell carcinoma (SCC). The patient opted for endoscopic resection.