tbuckley/cabot-search huggingface dataset:
Author Correction: Development and clinical deployment of a smartphone-based visual field deep learning system for glaucoma detection
Authors: Fei Li, Diping Song, Han Chen, Jian Xiong, Xingyi Li, Hua Zhong, Guangxian Tang, Sujie Fan, Dennis S. C. Lam, Weihua Pan, Yajuan Zheng, Ying Li, Guoxiang Qu, Junjun He, Zhe Wang, Ling Jin, Rouxi Zhou, Yunhe Song, Yi Sun, Weijing Cheng, Chunman Yang, Yazhi Fan, Yingjie Li, Hengli Zhang, Ye Yuan, Yang Xu, Yunfan Xiong, Lingfei Jin, Aiguo Lv, Lingzhi Niu, Yuhong Liu, Shaoli Li, Jiani Zhang, Linda M. Zangwill, Alejandro F. Frangi, Tin Aung, Ching-yu Cheng, Yu Qiao, Xiulan Zhang, Daniel S. W. Ting
Journal: npj Digital Medicine (2022)
Abstract P1-06-08: Metabolic diversity determines metastatic fitness of breast cancer brain-tropic cells
Authors: Srinivas Malladi
Journal: Cancer Research (2022)

Abstract HER2+ breast cancer patients presenting with either synchronous (S-BM), latent residual (Lat) or metachronous (M-BM) brain metastases have poor survival outcomes. However, the basis for disparate metastatic fitness among disseminated tumor cells of similar oncotype within a distal organ remains unknown. Employing isogenic HER2+ breast cancer brain metastasis models, we show metabolic diversity and plasticity within brain-tropic cells determines metastatic fitness. Lactate secreted by aggressive metastatic cells (S-BM and M-BM) or lactate supplementation to mice bearing latent residual disease limits innate immune surveillance and triggers overt metastasis. Attenuating lactate metabolism in S-BM impedes metastasis, while M-BM adapt and survive as latent residual disease. In contrast to S-BM, Lat and M-BM survive in equilibrium with innate immune surveillance, oxidize glutamine and maintain cellular redox homeostasis through the anionic amino acid transporter xCT. Moreover, xCT expression is significantly higher in matched metachronous brain metastatic samples compared to primary tumors from HER2+ breast cancer patients. Genetic or pharmacological blockade of xCT eradicates residual disease and brain metastatic relapse in these preclinical models. Citation Format: Srinivas Malladi. Metabolic diversity determines metastatic fitness of breast cancer brain-tropic cells [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P1-06-08.
RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1
Authors: Lin Yuan, Shichen Bu, Meng Du, Yilong Wang, Chenhui Ju, Dandan Huang, Wenjing Xu, Xin Tan, Minglu Liang, Shan Deng, Liu Yang, Kai Huang
Journal: Cardiovascular Research (2022)

Abstract Aims The heart undergoes pathological remodelling, featured by the hypertrophic growth of cardiomyocytes and increased cardiac fibrosis, under biomechanical stress such as haemodynamic overload. Ring Finger Protein 207 (RNF207) is an E3 ubiquitin ligase that is predominantly expressed in the heart, but its function remains elusive. In this study, we aimed to explore the role of RNF207 in the development of pathological cardiac hypertrophy and dysfunction. Methods and results Transverse aortic constriction (TAC) surgery was performed on mice to induce cardiac hypertrophy. Cardiac function and remodelling were evaluated by echocardiography, histological assessment, and molecular analyses. Our data indicated that RNF207 overexpression (OE) exacerbated cardiac hypertrophy, fibrosis, and systolic dysfunction. In contrast, TAC-induced cardiac remodelling was profoundly blunted in RNF207 knockdown (KD) hearts. In line with the in vivo findings, RNF207 OE augmented, whereas RNF207 KD alleviated, phenylephrine-induced cardiomyocyte hypertrophy in vitro. Mechanistically, we demonstrated that RNF207 elicited detrimental effects by promoting K63-linked ubiquitination of TAK1-binding protein 1 (TAB1), which triggered the autophosphorylation of transforming growth factor-β activated kinase 1 (TAK1) and the activation of downstream p38 and c-Jun N-terminal kinase (JNK)1/2 signalling pathways. In the TAB1-KD cardiomyocytes, RNF207-OE-induced cell hypertrophy was significantly attenuated, indicating that RNF207-induced hypertrophy is, at least in part, TAB1-dependent. Conclusions This study demonstrates that RNF207 exacerbates pressure overload-induced cardiac hypertrophy and dysfunction via post-translational modification of TAB1.
Testing availability, positioning, promotions, and signage of healthier food options and purchasing behaviour within major UK supermarkets: Evaluation of 6 nonrandomised controlled intervention studies
Authors: Carmen Piernas, Georgina Harmer, Susan A. Jebb
Journal: PLoS Medicine (2022)

Background Governments are increasingly looking for policies to change supermarket environments to support healthier food purchasing. We evaluated 6 interventions within major United Kingdom grocery stores, including availability, positioning, promotions, and signage strategies to encourage selection of healthier products. Methods and findings Nonrandomised controlled study designs were used, except for one intervention that was rolled out nationwide using a pre/post within-store design. Store-level weekly sales (units, weight (g), and value (£)) of products targeted in the interventions were used in primary analyses using multivariable hierarchical models and interrupted time series (ITS) analyses. Stocking low fat chips next to regular chips was associated with decreases in sales of regular chips (units) in intervention versus control stores (−23% versus −4%; P = 0.001) with a significant level change in ITS models ( P = 0.001). Increasing availability of lower energy packs of biscuits was associated with increased sales but reduced sales of regular biscuits in intervention versus control stores (lower energy biscuits +18% versus −2%; P = 0.245; regular biscuits −4% versus +7%; P = 0.386), although not significantly, though there was a significant level change in ITS models ( P = 0.004 for regular biscuits). There was no evidence that a positioning intervention, placing higher fibre breakfast cereals at eye level was associated with increased sales of healthier cereal or reduced sales of regular cereal. A price promotion on seasonal fruits and vegetables showed no evidence of any greater increases in sales of items on promotion in intervention versus control stores (+10% versus +8%; P = 0.101) but a significant level change in ITS models ( P &lt; 0.001). A nationwide promotion using Disney characters was associated with increased sales of nonsugar baked beans (+54%) and selected fruits (+305%), with a significant level change in ITS models ( P &lt; 0.001 for both). Shelf labels to highlight lower sugar beverages showed no evidence of changes in purchasing of lower or higher sugar drinks. These were all retailer-led interventions that present limitations regarding the lack of randomisation, residual confounding from unmeasured variables, absolute differences in trends and sales between intervention versus control stores, and no independent measures of intervention fidelity. Conclusions Increasing availability and promotions of healthier alternatives in grocery stores may be promising interventions to encourage purchasing of healthier products instead of less healthy ones. There was no evidence that altering positioning within an aisle or adding shelf edge labelling is associated with changes in purchasing behaviours. Trial registration https://osf.io/br96f/ .
Clinical effectiveness of music interventions for dementia and depression in elderly care (MIDDEL): Australian cohort of an international pragmatic cluster-randomised controlled trial
Authors: Felicity A Baker, Young-Eun C Lee, Tanara Vieira Sousa, Phoebe A Stretton-Smith, Jeanette Tamplin, Vigdis Sveinsdottir, Monika Geretsegger, Jo Dugstad Wake, Jörg Assmus, Christian Gold
Journal: The Lancet Healthy Longevity (2022)
NON-HISPANIC BLACK AND AFRICAN AMERICAN (NHB/AA) PATIENTS: UNDERREPORTED AND UNDERREPRESENTED IN RANDOMIZED CONTROLLED TRIALS OF LIPID LOWERING THERAPY
Authors: Jelani Kayode Grant, Michael Dangl, Margaret Koester, Mickias Tegegn, Leonardo Mees Knijnik, Harjit Singh, Carl E. Orringer
Journal: Journal of the American College of Cardiology (2022)
Allergic and hypersensitivity conditions in non‐specialist care: Flow diagrams to support clinical practice
Authors: Dermot Ryan, Bertine M. J. Flokstra – de Blok, Evangéline Clark, Clara Gaudin, Myriam Mamodaly, Janwillem Kocks, Jantina Lucia van der Velde, Liz Angier, Kerstin Romberg, Radek Gawlik, Pascal Demoly, Luciana Kase Tanno
Journal: Allergy (2022)

Abstract Most patients presenting with allergies are first seen by primary care health professionals. The perceived knowledge gaps and educational needs were recently assessed in response to which the LOGOGRAM Task Force was established with the remit of constructing pragmatic flow diagrams for common allergic conditions in line with an earlier EAACI proposal to develop simplified pathways for the diagnosis and management of allergic diseases in primary care. To address the lack of accessible and pragmatic guidance, we designed flow diagrams for five major clinical allergy conditions: asthma, anaphylaxis, food allergy, drug allergy, and urticaria. Existing established allergy guidelines were collected and iteratively distilled to produce five pragmatic and accessible tools to aid diagnosis and management of these common allergic problems. Ultimately, they should now be validated prospectively in primary care settings.
30 DAYS ACUTE ISCHEMIC STROKE (AIS) READMISSION AFTER TAVR (TRANS-AORTIC VALVE REPLACEMENT)
Authors: Juan Del Cid Fratti, Udit Joshi, Ezequiel Munoz, Keattiyoat Wattanakit, Sudhir Mungee
Journal: Journal of the American College of Cardiology (2022)
BRIDGING THE GENDER DIVIDE IN CARDIOVASCULAR REHABILITATION: A WORK IN PROGRESS
Authors: Rachid A. Elkoustaf, Maureen Nwaokoro, Debora A. Lahti, Janis F. Yao, Nancy Gin, Timothy M. Cotter, Tadashi T. Funahashi, Columbus D. Batiste
Journal: Journal of the American College of Cardiology (2022)
REMNANT CHOLESTEROL IN PATIENTS WITH ESTABLISHED CARDIOVASCULAR DISEASE PREDICTS CARDIOVASCULAR EVENTS BOTH AMONG PATIENTS WITH TYPE 2 DIABETES AND AMONG NON-DIABETIC SUBJECTS
Authors: Arthur Mader, Lukas Sprenger, Alexander Vonbank, Barbara Larcher, Maximilian Maechler, Valentin Grabher, Andreas Leiherer, Axel Muendlein, Heinz Drexel, Christoph H. Saely
Journal: Journal of the American College of Cardiology (2022)
AJM300 (carotegrast methyl), an oral antagonist of α4-integrin, as induction therapy for patients with moderately active ulcerative colitis: a multicentre, randomised, double-blind, placebo-controlled, phase 3 study
Authors: Katsuyoshi Matsuoka, Mamoru Watanabe, Toshihide Ohmori, Koichi Nakajima, Tetsuya Ishida, Yoh Ishiguro, Kazunari Kanke, Kiyonori Kobayashi, Fumihito Hirai, Kenji Watanabe, Hidehiro Mizusawa, Shuji Kishida, Yoshiharu Miura, Akira Ohta, Toshifumi Kajioka, Toshifumi Hibi, Satoshi Motoya, Atsuo Maemoto, Mikihiro Fujiya, Toshifumi Ashida, Mitsuru Goto, Takayuki Matsumoto, Yasuo Suzuki, Yukihiro Hamahata, Tomoo Nakagawa, Naoya Kato, Jun Kato, Yutaka Endo, Ryoichi Suzuki, Koichiro Matsuda, Naoki Ohmiya, Shinji Katsushima, Shuhei Hosomi, Ken-ichi Tarumi, Chiyuki Watanabe, Mitsuru Saito, Yuichiro Yokoyama, Tomoki Inaba, Yasuhisa Sakata, Hitoshi Hongo, Tomoyoshi Shibuya, Kazuhiko Kawakami, Yoichi Kakuta, Atsushi Irisawa, Naoki Yoshimura, Katsuyuki Fukuda, Takayuki Shirai, Hitoshi Ichikawa, Junko Nagata, Takayoshi Suzuki, Kaoru Yokoyama, Takashi Tomidokoro, Yuichiro Kojima, Masahiro Yamada, Hideko Yamamoto, Takayuki Yamamoto, Noriyuki Horiki, Hirozumi Obata, Satoko Inoue, Shinji Tanaka, Tatsuya Toyokawa, Masaki Kunihiro, Takashi Hisabe, Shinichi Ogata, Fuminao Takeshima, Kayoko Matsushima, Nobuyuki Matsuhashi, Hirotake Sakuraba, Masahiro Iwabuchi, Akihiko Tsuchiya, Kan Uchiyama, Takanori Kanai, Masanao Nakamura, Tadashi Yokoyama, Nobuyuki Hida, Keiichi Mitsuyama, Taro Osada, Sakiko Hiraoka, Tomoyuki Tsuzuki, Takashige Masuo, Ryota Hokari, Taku Kobayashi, Masayuki Saruta, Masao Araki, Hiroshi Araki, Masahito Shimizu, Masakazu Kikuchi, Takahiro Nishikawa, Hidetoshi Takedatsu, Kunihiko Aoyagi, Toshiaki Ochiai, Nobuo Toda, Yuji Mizokami, Masakazu Nagahori, Kazuhiro Matsueda, Hitoshi Kino, Akira Kanamori, Tsunehiro Suzuki, Toshiharu Sakurai, Masatoshi Kudo, Atsuo Kitano, Tadakazu Hisamatsu, Shinji Kumagai, Tomoyuki Ninomiya, Kenichiro Mori, Shun-ichi Yoshida, Mitsuhide Goto
Journal: The Lancet. Gastroenterology & hepatology (2022)
LONG-TERM HEALTHCARE UTILIZATION IN PATIENTS UNDERGOING CONGENITAL HEART SURGERY: A 10-YEAR STATEWIDE ANALYSIS
Authors: Sarah Crook, Kacie Dragan, Joyce L. Woo, Matthew Neidell, Stephen Cook, Edward L. Hannan, Jane W. Newburger, Marshall L. Jacobs, Emile Bacha, Christopher J. Petit, Robert Vincent, Kathleen E. Walsh-Spoonhower, Ralph Mosca, T.K. Susheel Kumar, Neil Devejian, Steven A. Kamenir, George Alfieris, Michael F. Swartz, David Meyer, Erin A. Paul, John Billings, Brett R. Anderson
Journal: Journal of the American College of Cardiology (2022)
KMT2C methyltransferase domain regulated INK4A expression suppresses prostate cancer metastasis
Authors: Tanja Limberger, Michaela Schlederer, Karolina Trachtová, Ines Garces de los Fayos Alonso, Jiaye Yang, Sandra Högler, Christina Sternberg, Vojtech Bystry, Jan Oppelt, Boris Tichý, Margit Schmeidl, Petra Kodajova, Anton Jäger, Heidi A. Neubauer, Monika Oberhuber, Belinda S. Schmalzbauer, Sarka Pospisilova, Helmut Dolznig, Wolfgang Wadsak, Zoran Culig, Suzanne D. Turner, Gerda Egger, Sabine Lagger, Lukas Kenner
Journal: Molecular Cancer (2022)

Frequent truncation mutations of the histone lysine N-methyltransferase KMT2C have been detected by whole exome sequencing studies in various cancers, including malignancies of the prostate. However, the biological consequences of these alterations in prostate cancer have not yet been elucidated.To investigate the functional effects of these mutations, we deleted the C-terminal catalytic core motif of Kmt2c specifically in mouse prostate epithelium. We analysed the effect of Kmt2c SET domain deletion in a Pten-deficient PCa mouse model in vivo and of truncation mutations of KMT2C in a large number of prostate cancer patients.We show here for the first time that impaired KMT2C methyltransferase activity drives proliferation and PIN formation and, when combined with loss of the tumour suppressor PTEN, triggers loss of senescence, metastatic dissemination and dramatically reduces life expectancy. In Kmt2c-mutated tumours we show enrichment of proliferative MYC gene signatures and loss of expression of the cell cycle repressor p16INK4A. In addition, we observe a striking reduction in disease-free survival of patients with KMT2C-mutated prostate cancer.We identified truncating events of KMT2C as drivers of proliferation and PIN formation. Loss of PTEN and KMT2C in prostate cancer results in loss of senescence, metastatic dissemination and reduced life expectancy. Our data demonstrate the prognostic significance of KMT2C mutation status in prostate cancer patients. Inhibition of the MYC signalling axis may be a viable treatment option for patients with KMT2C truncations and therefore poor prognosis.
Mild SARS-CoV-2 infection in rhesus macaques is associated with viral control prior to antigen-specific T cell responses in tissues
Authors: Christine E. Nelson, Sivaranjani Namasivayam, Taylor W. Foreman, Keith D. Kauffman, Shunsuke Sakai, Danielle E. Dorosky, Nickiana E. Lora, Kelsie Brooks, E. Lake Potter, Nicole L. Garza, Bernard A. P. Lafont, Reed F. Johnson, Mario Roederer, Alan Sher, Daniela Weiskopf, Alessandro Sette, Emmie de Wit, Heather D. Hickman, Jason M. Brenchley, Laura E. Via, Daniel L. Barber, Ayan Abdi, Emmuanual K. Dayao, Joel D. Fleegle, Felipe Gomez, Michaela K. Piazza, Katelyn M. Repoli, Becky Y. Sloan, Ashley L. Butler, April M. Walker, Danielle M. Weiner, Michael J. Woodcock, Alexandra Vatthauer
Journal: Science Immunology (2022)

SARS-CoV-2 primarily replicates in mucosal sites, and more information is needed about immune responses in infected tissues. Here, we used rhesus macaques to model protective primary immune responses in tissues during mild COVID-19. Viral RNA levels were highest on days 1-2 post-infection and fell precipitously thereafter.
MILD OR ASYMPTOMATIC COVID-19 INFECTION IS ASSOCIATED WITH A HIGH LIKELIHOOD OF SPECT MYOCARDIAL PERFUSION ABNORMALITIES EVEN IN THE ABSENCE OF OBSTRUCTIVE CORONARY ARTERY DISEASE
Authors: Beom Soo Kim, Ariel Yu, Stephanie Busch, James Lassen, John N. Makaryus
Journal: Journal of the American College of Cardiology (2022)
COVID-19 ASSOCIATED ACUTE THROMBOTIC ST-ELEVATION MYOCARDIAL INFARCTION IN AN ADOLESCENT: MANAGEMENT WITH INTRACORONARY AND SYSTEMIC THROMBOLYSIS
Authors: Kimberly Wilson, Marc Katz, Simon Koo, Matthew Krinock, Vivek Amit Modi, Haley Kavelak, Elizabeth Adams, Laura Czulada, Jamshid Shirani, Luis A. Tejada
Journal: Journal of the American College of Cardiology (2022)
Mycobacterium tuberculosis transmission in Birmingham, UK, 2009–19: An observational study
Authors: Timothy M. Walker, Marc Choisy, Martin Dedicoat, Philip G. Drennan, David Wyllie, Fan Yang-Turner, Derrick W. Crook, Esther R. Robinson, A. Sarah Walker, E. Grace Smith, Timothy E.A. Peto
Journal: The Lancet Regional Health - Europe (2022)

Over 10-years of whole-genome sequencing (WGS) of Mycobacterium tuberculosis in Birmingham presents an opportunity to explore epidemiological trends and risk factors for transmission in new detail. Between 1st January 2009 and 15th June 2019, we obtained the first WGS isolate from every patient resident in a postcode district covered by Birmingham's centralised tuberculosis service. Data on patients' sex, country of birth, social risk-factors, anatomical locus of disease, and strain lineage were collected. Poisson harmonic regression was used to assess seasonal variation in case load and a mixed-effects multivariable Cox proportionate hazards model was used to assess risk factors for a future case arising in clusters defined by a 5 single nucleotide polymorphism (SNP) threshold, and by 12 SNPs in a sensitivity analysis. 511/1653 (31%) patients were genomically clustered with another. A seasonal variation in diagnoses was observed, peaking in spring, but only among clustered cases. Risk-factors for a future clustered case included UK-birth (aHR=2·03 (95%CI 1·35–3·04), p < 0·001), infectious (pulmonary/laryngeal/miliary) tuberculosis (aHR=3·08 (95%CI 1·98-4·78), p < 0·001), and M. tuberculosis lineage 3 (aHR=1·91 (95%CI 1·03–3·56), p = 0·041) and 4 (aHR=2·27 (95%CI 1·21–4·26), p = 0·011), vs. lineage 1. Similar results pertained to 12 SNP clusters, for which social risk-factors were also significant (aHR 1·72 (95%CI 1·02–2·93), p = 0·044). There was marked heterogeneity in transmission patterns between postcode districts. There is seasonal variation in the diagnosis of genomically clustered, but not non-clustered, cases. Risk factors for clustering include UK-birth, infectious forms of tuberculosis, and infection with lineage 3 or 4. Wellcome Trust, MRC, UKHSA
DISPARITIES IN OUTCOMES OF PREECLAMPSIA HOSPITALIZATIONS STRATIFIED BY RACE AND MEDIAN HOUSEHOLD INCOME: INSIGHTS FROM THE U.S. NATIONAL INPATIENT SAMPLE (2004-2018)
Authors: Salman Zahid, Mian Tanveer Ud Din, Anum Minhas, Devesh Rai, Muhammad Zia Khan, Waqas Ullah, Harriette Gillian Christine Van Spall, Allison G. Hays, Erin D. Michos
Journal: Journal of the American College of Cardiology (2022)
LYMPHOPENIA AS A BIOMARKER PRE AND POST LEFT VENTRICULAR DEVICE IMPLANT
Authors: Brittany Tsou, Fatimah Alkhunaizi, Paul Scheel, Nisha Aggarwal Gilotra, Ahmet Kilic, Kavita Sharma, Steven Hsu, Kristin M. Stawiarski
Journal: Journal of the American College of Cardiology (2022)
Insight into the ecology of vaginal bacteria through integrative analyses of metagenomic and metatranscriptomic data
Authors: Michael T. France, Li Fu, Lindsay Rutt, Hongqiu Yang, Michael S. Humphrys, Shilpa Narina, Pawel M. Gajer, Bing Ma, Larry J. Forney, Jacques Ravel
Journal: Genome biology (2022)

Vaginal bacterial communities dominated by Lactobacillus species are associated with a reduced risk of various adverse health outcomes. However, somewhat unexpectedly, many healthy women have microbiota that are not dominated by lactobacilli. To determine the factors that drive vaginal community composition we characterized the genetic composition and transcriptional activities of vaginal microbiota in healthy women.
Genes That Escape X Chromosome Inactivation Modulate Sex Differences in Valve Myofibroblasts
Authors: Brian A. Aguado, Cierra J. Walker, Joseph C. Grim, Megan E. Schroeder, Dilara Batan, Brandon J. Vogt, Andrea Gonzalez Rodriguez, Jessica A. Schwisow, Karen S. Moulton, Robert M. Weiss, Donald D. Heistad, Leslie A. Leinwand, Kristi S. Anseth
Journal: Circulation (2022)

Background: Aortic valve stenosis is a sexually dimorphic disease, with women often presenting with sustained fibrosis and men with more extensive calcification. However, the intracellular molecular mechanisms that drive these clinically important sex differences remain underexplored. Methods: Hydrogel biomaterials were designed to recapitulate key aspects of the valve tissue microenvironment and to serve as a culture platform for sex-specific valvular interstitial cells (VICs; precursors to profibrotic myofibroblasts). The hydrogel culture system was used to interrogate intracellular pathways involved in sex-dependent VIC-to-myofibroblast activation and deactivation. RNA sequencing was used to define pathways involved in driving sex-dependent activation. Interventions with small molecule inhibitors and siRNA transfections were performed to provide mechanistic insight into sex-specific cellular responses to microenvironmental cues, including matrix stiffness and exogenously delivered biochemical factors. Results: In both healthy porcine and human aortic valves, female leaflets had higher baseline activation of the myofibroblast marker α-smooth muscle actin compared with male leaflets. When isolated and cultured, female porcine and human VICs had higher levels of basal α-smooth muscle actin stress fibers that further increased in response to the hydrogel matrix stiffness, both of which were higher than in male VICs. A transcriptomic analysis of male and female porcine VICs revealed Rho-associated protein kinase signaling as a potential driver of this sex-dependent myofibroblast activation. Furthermore, we found that genes that escape X-chromosome inactivation such as BMX and STS (encoding for Bmx nonreceptor tyrosine kinase and steroid sulfatase, respectively) partially regulate the elevated female myofibroblast activation through Rho-associated protein kinase signaling. This finding was confirmed by treating male and female VICs with endothelin-1 and plasminogen activator inhibitor-1, factors that are secreted by endothelial cells and known to drive myofibroblast activation through Rho-associated protein kinase signaling. Conclusions: Together, in vivo and in vitro results confirm sex dependencies in myofibroblast activation pathways and implicate genes that escape X-chromosome inactivation in regulating sex differences in myofibroblast activation and subsequent aortic valve stenosis progression. Our results underscore the importance of considering sex as a biological variable to understand the molecular mechanisms of aortic valve stenosis and to help guide sex-based precision therapies.
OUTCOMES OF INTRAVASCULAR IMAGING IN ORBITAL ATHERECTOMY; A NATIONAL INPATIENT SAMPLE DATABASE
Authors: Waqas Ullah, Mohamed Zghouzi, Omar J. Baqal, Hafez MA Abdullah, Nicholas J. Ruggiero, Abdul Mannan Khan Minhas, Sean J. Dikdan, David L. Fischman
Journal: Journal of the American College of Cardiology (2022)