tbuckley/cabot-search huggingface dataset:
HEMODYNAMIC AND STRUCTURAL CHANGES WITH LATE REPAIR OF ATRIAL SEPTAL DEFECTS WITH PULMONARY HYPERTENSION: CASE SERIES ON THE “TREAT-TO-CLOSE” STRATEGY
Authors: Arjun Mahendran, Hassan Alnuaimat, Ali Ataya, Mark Bleiweis, Jana Reid, Diego Moguillansky
Journal: Journal of the American College of Cardiology (2021)
A STANDARDIZED OUTPATIENT INTRAVENOUS DIURETIC CLINIC FOR HEART FAILURE PATIENTS GUIDED BY ADVANCED PRACTICE PROVIDERS IS SAFE AND FEASIBLE
Authors: Carolyn Marie Rosner, Karl Young, Aneel Maini, Aaron Bagnola, Shashank Desai, Carolyn Hahndorf, Mary Looby, Christopher O’Connor, Lauren Cooper
Journal: Journal of the American College of Cardiology (2021)
Controlling Hematopoietic Stem Cell Quiescence By Ablating the TGFβ-Responsive, Hematopoietic-Hpecific Enhancer of CDKN1C (p57)
Authors: Mia Yabut, Fabienne Brenet, Nassima Messali, Nicole Molle, Pouneh Kermani, Silvana Di Giandomenico, Matthew Brown, Joseph Scandura
Journal: Blood (2017)
It Is Time to End the Debate Over School Reopening
Authors: Danielle G. Dooley, Dimitri Christakis
Journal: JAMA Network Open (2021)

Tali Raviv, PhD; Christopher M. Warren, PhD; Jason J. Washburn, PhD; Madeleine K. Kanaley, BA; Liga Eihentale, BA; Hayley Jane Goldenthal, MA, MS; Jaclyn Russo, PhD; Caroline P. Martin, BA; Lisa S. Lombard, PhD; Jamie Tully, MS, MPH; Kenneth Fox, MD; Ruchi Gupta, MD, MPH
Soluble and Microparticle‐Based Delivery of TLR4 and TLR9 Agonists Differentially Modulate 3D Chemotaxis of Bone Marrow‐Derived Dendritic Cells
Authors: Alexandra Atalis, J. Brandon Dixon, Krishnendu Roy
Journal: Advanced Healthcare Materials (2021)

Abstract Vaccines are commonly administered subcutaneously or intramuscularly, and local immune cells, notably dendritic cells (DCs), play a significant role in transporting vaccine antigens and adjuvants to draining lymph nodes. Here, it is compared how soluble and biomaterial‐mediated delivery of Toll‐like receptor (TLR)‐targeted adjuvants, monophosphoryl lipid A (MPLA, TLR4 ligand) and 5'‐C‐phosphate‐G‐3' DNA (CpG DNA, TLR9 ligand), modulate 3D chemotaxis of bone marrow‐derived dendritic cells (BMDCs) toward lymphatic chemokine gradients. Within microfluidic devices containing 3D collagen‐based matrices to mimic tissue conditions, soluble MPLA increases BMDC chemotaxis toward gradients of CCL19 and CCL21, while soluble CpG has no effect. Delivering CpG on poly(lactic‐ co ‐glycolic) acid microparticles (MPs) enhances BMDC chemotaxis compared to MPLA‐encapsulated MPs, and when co‐delivered, MPLA and CpG do not synergistically enhance BMDC migration. It is concluded that supplementing granulocyte‐macrophage colony stimulating factor‐derived BMDC culture with interleukin‐4 is necessary to induce CCR7 expression and chemotaxis of BMDCs. Different cell subsets in BMDC culture upregulate CCR7 in response to soluble versus biomaterial‐loaded MPLA and CpG, and CCR7 expression does not consistently correlate with functional migration. The results show both adjuvant type and delivery method influence chemotaxis of DCs, and these findings uncover new directions for the rational design of vaccine formulations.
USPSTF Recommendation Statement on Hypertension Screening in Adults—Where Do We Go From Here?
Authors: D. Edmund Anstey, Corey Bradley, Daichi Shimbo
Journal: JAMA Network Open (2021)

US Preventive Services Task Force; Alex H. Krist, MD, MPH; Karina W. Davidson, PhD, MASc; Carol M. Mangione, MD, MSPH; Michael Cabana, MD, MA, MPH; Aaron B. Caughey, MD, PhD; Esa M. Davis, MD, MPH; Katrina E. Donahue, MD, MPH; Chyke A. Doubeni, MD, MPH; Martha Kubik, PhD, RN; Li Li, MD, PhD, MPH; Gbenga Ogedegbe, MD, MPH; Lori Pbert, PhD; Michael Silverstein, MD, MPH; James Stevermer, MD, MSPH; Chien-Wen Tseng, MD, MPH, MSEE; John B. Wong, MD
IgG Fe gama receptor IIa (Fe gamaRIIa) polymorphism is associatedwith lupus nephritis (LN) and proliferativeprimary glomerulonephritis (GN) in brazilian patients
Authors: Adriana Peixoto Gelmetti, Antonio Carlos Freitas, Viktória Woronik, Rui Toledo Barros, Renato Rocha Monteiro
Journal: Journal of the American Society of Nephrology (2004)
Erratum: A previously unidentified MECP2 open reading frame defines a new protein isoform relevant to Rett syndrome
Authors: G N Mnatzakanian, H Lohi, I Munteanu, S E Alfred, T Yamada, P J M MacLeod, J R Jones, S W Scherer, N C Schanen, M J Friez, J B Vincent, B A Minassian
Journal: Nature Genetics (2004)
Host-Dependent Phenotypic Resistance to EGFR Tyrosine Kinase Inhibitors
Authors: Yuya Haga, Ilaria Marrocco, Ashish Noronha, Mary Luz Uribe, Nishanth Belugali Nataraj, Arunachalam Sekar, Diana Drago-Garcia, Simone Borgoni, Moshit Lindzen, Suvendu Giri, Stefan Wiemann, Yasuo Tsutsumi, Yosef Yarden
Journal: Cancer Research (2021)

Lung cancers driven by mutant forms of EGFR invariably develop resistance to kinase inhibitors, often due to secondary mutations. Here we describe an unconventional mechanism of resistance to dacomitinib, a newly approved covalent EGFR kinase inhibitor, and uncover a previously unknown step of resistance acquisition. Dacomitinib-resistant (DR) derivatives of lung cancer cells were established by means of gradually increasing dacomitinib concentrations. These DR cells acquired no secondary mutations in the kinase or other domains of EGFR. Along with resistance to other EGFR inhibitors, DR cells acquired features characteristic to epithelial-mesenchymal transition, including an expanded population of aldehyde dehydrogenase-positive cells and upregulation of AXL, a receptor previously implicated in drug resistance. Unexpectedly, when implanted in animals, DR cells reverted to a dacomitinib-sensitive state. Nevertheless, cell lines derived from regressing tumors displayed renewed resistance when cultured in vitro. Three-dimensional and cocultures along with additional analyses indicated lack of involvement of hypoxia, fibroblasts, and immune cells in phenotype reversal, implying that other host-dependent mechanisms might nullify nonmutational modes of resistance. Thus, similar to the phenotypic resistance of bacteria treated with antibiotics, the reversible resisters described here likely evolve from drug-tolerant persisters and give rise to the irreversible, secondary mutation-driven nonreversible resister state. SIGNIFICANCE: This study reports that stepwise acquisition of kinase inhibitor resistance in lung cancers driven by mutant EGFR comprises a nonmutational, reversible resister state. GRAPHICAL ABSTRACT: http://cancerres.aacrjournals.org/content/canres/81/14/3862/F1.large.jpg.
Neuropilin-1 regulates tumor cell survival in lung cancer cell lines under serum depleted conditions
Authors: Graham P. Pidgeon, Martin P. Barr, Maryclare Cathcart, Kenneth O’Byrne
Journal: Cancer Research (2005)

785  Background : Neuropilin-1 (NRP-1) is an isoform-specific receptor for vascular endothelial growth factor (VEGF165) and semaphorin3A, initially discovered on migrating neurons. We previously reported that VEGF had an autocrine survival effect on breast carcinoma cell lines through an upregulation of BCL-2 expression. NRP-1 expression has also been reported on a number of tumour cell lines in the absence of the other VEGF receptors, where it mediates survival signals, possibly through VEGF signaling [1]. In this study we examined NRP-1 expression in a panel of lung cancer cell lines and in retrospective human lung tumours. Results: NRP-1 expression was examined in four lung cancer cell lines by western blot and immunocytochemistry. A549, SKMES-1 and H647 cell lines were all strongly positive for NRP-1 expression, while NRP-1 expression was absent in H460 cells. NRP-1 localisation in the leading edges of cell protrusions was particularly noted, implicating their role in cell migration. Cell survival in 0.5% serum conditions was examined following treatment with various concentration of neutralizing antibodies to NRP-1 by Bromo deoxyUridine (BrdU) assay. All three cell lines positive for NRP-1 displayed reduced survival following treatment with NRP-1 ab (1μg/ml) compared to controls (A549 36%, SKMES-1 51%, H647 43%), while no inhibition of survival was observed on H460 cell line (104%). These results confirmed the selectivity of the neutralizing antibody. The reduction in survival was accompanied by an increase in apoptosis as determined by TUNEL labeling and FACS analysis in each of the NRP-1 positive cell lines. Treatment with recombinant VEGF (100 ng/ml) had no effect on survival inhibition following NRP-1 neutralisation. This suggests that NRP-1 may regulate survival in the lung cancer cell lines through VEGF signaling. In human lung cancer specimens, NRP-1 expression was examined by immunohistochemistry. NRP-1 immunostaining was observed in many forms of lung cancers, with a particularly strong expression noted in NSCLC relative to normal tissue. Conclusions : These results implicate NRP-1 signaling as an important survival pathway in lung cancers. We are currently focusing on regulators of NRP-1 expression in lung cancers, with a view to developing new treatment strategies aimed at targeting this survival pathway.
Advances in photosensitizer-related design for photodynamic therapy
Authors: Zhaojie Zhou, Ling Zhang, Zhirong Zhang, Zhenmi Liu
Journal: Asian Journal of Pharmaceutical Sciences (2021)

Photodynamic therapy (PDT) is highly effective in treating tumors located near body surface, offering strong tumor suppression and low damage to normal tissue nearby. PDT is also effective for treating a number of other conditions. PDT not only provide a precise and selective method for the treatment of various diseases by itself, it can also be used in combination with other traditional therapies. Because PDT uses light as the unique targeting mechanism, it has simpler and more direct targeting capability than traditional therapies. The core material of a PDT system is the photosensitizer which converts light energy to therapeutic factors/substances. Different photosensitizers have their distinct characteristics, leading to different advantages and disadvantages. These could be enhanced or compensated by using proper PDT system. Therefore, the selected type of photosensitizer would heavily influence the overall design of a PDT system. In this article, we evaluated major types of inorganic and organic PDT photosensitizers, and discussed future research directions in the field.
MULTIDISCIPLINARY APPROACH AND BEST PRACTICES FOR USE OF PERCUTANEOUS VENTRICULAR ASSIST DEVICE FOR HIGH RISK VENTRICULAR TACHYCARDIA ABLATION
Authors: Amrit Kanwar, Hyungjin Kim, Tahmeed Contractor, Ravi Mandapati, Antoine Sakr, Dmitry Abramov, Anthony Hilliard, Melissa McCabe, Rahul Bhardwaj, Aditya Bharadwaj
Journal: Journal of the American College of Cardiology (2021)
Is resolve mainly about resisting hyperbolic discounting?
Authors: Don Ross
Journal: Behavioral and Brain Sciences (2021)

Abstract Ainslie insightfully refines the concept of willpower by emphasizing low-effort applications of resolve. However, he gives undue weight to intertemporal discounting as the problem that willpower is needed to overcome. Nonhumans typically don't encounter choices that differ only in the time of consumption. Humans learn to transform uncertainty into problems they can solve using culturally evolved mechanisms for quantifying risk.
IS IT SAFE TO DISCHARGE PATIENTS WITH TAKOTSUBO CARDIOMYOPATHY AND LONG QTC INTERVAL
Authors: Evangelia Vemmou, Ilias Nikolakopoulos, Meagan Nowariak, Christian Schmidt, Judit Karacsonyi, Iosif Xenogiannis, Emmanouil Brilakis, Scott W. Sharkey
Journal: Journal of the American College of Cardiology (2021)
TELE-PROCTORING: A NEW AVENUE TOWARDS PROCTORING CASES IN INTERVENTIONAL CARDIOLOGY
Authors: Imran Baig, Maulin Patel, Thomas Scott, Michael Friscia, Michael Bresticker, Heather Zimmerman, Mark Schneider, Spanner Van Zyl, Shikhar Agarwal
Journal: Journal of the American College of Cardiology (2021)
David Oliver: A vision for transparent post-covid government
Authors: David Oliver
Journal: BMJ (2021)

Among widespread calls for a public inquiry into England's response to the covid-19 pandemic, the King's Fund has proposed a potential framework for an inquiry under five key headings: "Intrinsic risk," "Public health response," "Healthcare system response," "Measures in wider society," and "Adult social care response." 1 All partly depend on the role of government and its agencies.I realise that a public inquiry can produce an evidenced narrative and recommendations, but the need and demand for one highlights a serious failure of open elected government and leadership at the highest levels.
IMPROVING PROCEDURAL EFFICIENCY DURING PERCUTANEOUS CORONARY INTERVENTIONS UTILIZING A STANDARDIZED OPTICAL COHERENCE TOMOGRAPHY (OCT) WORKFLOW: INSIGHTS FROM THE LIGHTLAB INITIATIVE
Authors: Eric Alexander Secemsky, Amir Darki, Matheen Khuddus, Bimal Padaliya, Nick West, Richard Rapoza, Jana Buccola, Hector Garcia Cabrera, Gregory Amis, Bassem Chehab
Journal: Journal of the American College of Cardiology (2021)
DEVELOPMENT OF A RISK SCORE TO PREDICT PROCEDURAL SUCCESS IN BIFURCATION PERCUTANEOUS CORONARY INTERVENTION
Authors: Ilias Nikolakopoulos, Evangelia Vemmou, Judit Karacsonyi, Bavana Rangan, Raviteja Guddeti, Santiago Garcia, Konstantinos Tsioufis, Gerasimos Siasos, Dimitris Tousoulis, Mario Gossl, Ivan Chavez, Michael Mooney, Jay Traverse, Yale Wang, Anil Poulose, Paul Sorajja, M. Nicholas Burke, Emmanouil Brilakis
Journal: Journal of the American College of Cardiology (2021)
Abstract 15483: Acute Normovolemic Hemodilution Enhances Platelet Function Recovery Following Cardiopulmonary Bypass
Authors: Eric Sarin, Kevin Bliden, Scott D Barnett, Patricia Saulino, Udaya Tantry, Ankit vyas, Alan M Speir, Paul A Gurbel
Journal: Circulation (2019)

Introduction: Acute Normovolemic Hemodilution (ANH) is an effective blood conservation method during cardiopulmonary bypass largely attributed to restoring circulating red blood cells. Hypothesis: ...
Old versus new gene therapy for globin disorders
Authors: Roland W. Herzog, Jörg Bungert
Journal: Molecular Therapy (2021)

Conventional treatments for inherited globin disorders such as β-thalassemia or sickle cell disease (SCD) are suboptimal. Blood transfusions are used to treat anemia, which is a typical complication of the severe forms of these diseases. Bone marrow transplant can result in a cure but comes with considerable risks. Thus, gene therapy to correct the defect in autologous hematopoietic stem cells (HSCs) would be an ideal treatment. Toward this goal, lentiviral (LV) gene transfer to CD34+ HSCs has been steadily improved over the years but is complicated by the difficulty to express adequate levels of β-globin. Now, the traditional gene addition approaches are competing with the new kid on the block, gene editing. Both approaches are being tested in multiple clinical trials, using a variety of technologies.
Postdiagnosis Aspirin Use Associated With Decreased Biliary Tract Cancer–Specific Mortality in a Large Nationwide Cohort
Authors: Shu‐Fen Liao, Jill Koshiol, Yi‐Hsiang Huang, Sarah S. Jackson, Yu‐Han Huang, Chi Chan, Claire Huang, Po‐Chun Liu, Yen‐Ju Chen, Rebecca J. Hsieh, Ching‐Po Huang, Sheng‐Nan Lu, Chien‐Jen Chen, Chen‐Yang Shen, Mei‐Hsuan Lee
Journal: Hepatology (2021)

Background and Aims Biliary tract cancer (BTC) is rare and has limited treatment options. We aimed to examine aspirin use on cancer‐specific survival in various BTC subtypes, including gallbladder cancer, ampulla of Vater cancer, and cholangiocarcinoma. Approach and Results Nationwide prospective cohort of newly diagnosed BTC between 2007 and 2015 were included and followed until December 31, 2017. Three nationwide databases, namely the Cancer Registration, National Health Insurance, and Death Certification System, were used for computerized data linkage. Aspirin use was defined as one or more prescriptions, and the maximum defined daily dose was used to evaluate the dose–response relationship. Cox’s proportional hazards models were applied for estimating HRs and 95% CIs. Analyses accounted for competing risk of cardiovascular deaths, and landmark analyses to avoid immortal time bias were performed. In total, 2,519 of patients with BTC were exposed to aspirin after their diagnosis (15.7%). After a mean follow‐up of 1.59 years, the 5‐year survival rate was 27.4%. The multivariate‐adjusted HR for postdiagnosis aspirin users, as compared with nonusers, was 0.55 (95% CI: 0.51 to 0.58) for BTC‐specific death. Adjusted HRs for BTC‐specific death were 0.53 (95% CI: 0.48 to 0.59) and 0.42 (95% CI: 0.31 to 0.58) for ≤ 1 and &gt; 1 maximum defined daily dose, respectively, and showed a dose–response trend ( P &lt; 0.001; nonusers as a reference). Cancer‐specific mortality was lower with postdiagnosis aspirin use in patients with all major BTC subtypes. Conclusions The nationwide study revealed that postdiagnosis aspirin use was associated with improved BTC‐specific mortality of various subtypes. The findings suggest that additional randomized trials are required to investigate aspirin’s efficacy in BTC.
CARDIAC BIOMARKERS AND LEFT VENTRICULAR FUNCTION IN RELATION TO VASCULAR BRAIN INJURY AND COGNITIVE FUNCTIONING
Authors: Raquel Amier, N. Marcks, A. Leeuwis, Robin Nijveldt, GJ Biessels, LJ Kappelle, R. van Oostenbrugge, RJ van der Geest, Michiel Bots, J. Greving, Wiro Niessen, J. de Bresser, S. Mooijaart, W. van der Flier, Hans-Peter Brunner-La Rocca, Albert van Rossum
Journal: Journal of the American College of Cardiology (2021)
ECHOCARDIOGRAPHIC SCREENING FOR EVALUATION OF FAMILY RISK OF RHEUMATIC HEART DISEASE - DATA FROM THE PROVAR+ STUDY
Authors: Bruno Ramos Nascimento, Juliane Franco, Andrea Beaton, Kaciane K.B. Oliveira, Marcia Barbosa, Antonio Ribeiro, Rodrigo T.L. Rocha, Breno C.M. Spolaor, Carolina F. Campos, Guilherme C.F. Oliveira, Maria Cecília L. Nassif, Talisson T. Barros, Leonardo A.M. Raso, Craig Sable, Maria Carmo Nunes
Journal: Journal of the American College of Cardiology (2021)
Progesterone promotes immunomodulation and tumor development in the murine mammary gland
Authors: Lauryn R Werner, Katelin A Gibson, Merit L Goodman, Dominika E Helm, Katherine R Walter, Sean M Holloran, Gloria M Trinca, Richard C Hastings, Howard H Yang, Ying Hu, Junping Wei, Gangjun Lei, Xiao-Yi Yang, Rashna Madan, Alfredo A Molinolo, Mary A Markiewicz, Prabhakar Chalise, Margaret L Axelrod, Justin M Balko, Kent W Hunter, Zachary C Hartman, Carol A Lange, Christy R Hagan
Journal: Journal for ImmunoTherapy of Cancer (2021)

Clinical studies have linked usage of progestins (synthetic progesterone [P4]) to breast cancer risk. However, little is understood regarding the role of native P4, signaling through the progesterone receptor (PR), in breast tumor formation. Recently, we reported a link between PR and immune signaling pathways, showing that P4/PR can repress type I interferon signaling pathways. Given these findings, we sought to investigate whether P4/PR drive immunomodulation in the mammary gland and promote tumor formation.
Single-cell dissection of cellular components and interactions shaping the tumor immune phenotypes in ovarian cancer
Authors: Milena Hornburg, Mélanie Desbois, Shan Lu, Yinghui Guan, Amy A. Lo, Susan Kaufman, Ashley Elrod, Alina Lotstein, Teresa M. DesRochers, Jose L. Munoz-Rodriguez, Xingwei Wang, Jennifer Giltnane, Oleg Mayba, Shannon J. Turley, Richard Bourgon, Anneleen Daemen, Yulei Wang
Journal: Cancer Cell (2021)
POLYPHARMACY IN A GLOBAL COHORT OF PATIENTS TAKING ANTICOAGULANTS FOR ATRIAL FIBRILLATION: THE GLORIA-AF REGISTRY
Authors: Dana Button, Valentina Bayer, Brian Olshansky, Peter Larsen, Christine Teutsch, Sagar Patel, Menno Huisman, Gregory Lip, Bory Kea
Journal: Journal of the American College of Cardiology (2021)
The Transcriptional Coactivator, ALL1‐Fused Gene From Chromosome 9, Simultaneously Sustains Hypoxia Tolerance and Metabolic Advantages in Liver Cancer
Authors: Hua Yu, Jun He, Wei Liu, Shuya Feng, Li Gao, Yingying Xu, Yawei Zhang, Xuyang Hou, Yan Zhou, Leping Yang, Xiongjun Wang
Journal: Hepatology (2021)

Background and Aims Proteins that recognize epigenetic modifications function as mediators to interpret epigenetic codes. Hypoxia response and metabolic rewiring are two major events during cancer progression. However, whether and how the epigenetic regulator integrates hypoxia response and metabolism together remain open for study. Approach and Results We data mined the clinical association of 33 histone lysine acetylation reader proteins with liver cancer and found that ALL1‐fused gene from chromosome 9 (AF9) is up‐regulated in cancer and correlates with tumor stage and poor prognosis. Conditional deletion of Af9 in mouse liver resulted in decreased tumor formation induced by c‐MET proto‐oncogene/β‐catenin. Loss of AF9 heavily impaired cell proliferation and completely blocked solid tumor formation. We further discovered that AF9 formed a positive feedback circuit with hypoxia‐inducible factor 1 alpha (HIF1α) and also stabilized MYC proto‐oncogene (cMyc). Mechanically, AF9 interacted with HIF1α and targeted HIF1A promoter whereas AF9 recognized cMyc acetylation at K148, protected cMyc phosphorylation at S62, and then stabilized cMyc, which, in turn, up‐regulates phosphofructokinase, platelet expression. Otherwise, knockout of Af9 in mouse hepatocytes increased the infiltration of CD8 + T cells, which is linked to the down‐regulation of lactate dehydrogenase A. Conclusions AF9 is up‐regulated to promote gene expression of hypoxia tolerance and glycolysis by simultaneously forming a complex with HIF1α and recognizing acetylated cMyc. Our results establish the oncogenic role of AF9 in human liver cancer, which could be a potential target for designing drugs against liver cancer.
Small extracellular vesicles in cancer
Authors: Komal Abhange, Amy Makler, Yi Wen, Natasha Ramnauth, Wenjun Mao, Waseem Asghar, Yuan Wan
Journal: Bioactive Materials (2021)

Extracellular vesicles (EV) are lipid-bilayer enclosed vesicles in submicron size that are released from cells. A variety of molecules, including proteins, DNA fragments, RNAs, lipids, and metabolites can be selectively encapsulated into EVs and delivered to nearby and distant recipient cells. In tumors, through such intercellular communication, EVs can regulate initiation, growth, metastasis and invasion of tumors. Recent studies have found that EVs exhibit specific expression patterns which mimic the parental cell, providing a fingerprint for early cancer diagnosis and prognosis as well as monitoring responses to treatment. Accordingly, various EV isolation and detection technologies have been developed for research and diagnostic purposes. Moreover, natural and engineered EVs have also been used as drug delivery nanocarriers, cancer vaccines, cell surface modulators, therapeutic agents and therapeutic targets. Overall, EVs are under intense investigation as they hold promise for pathophysiological and translational discoveries. This comprehensive review examines the latest EV research trends over the last five years, encompassing their roles in cancer pathophysiology, diagnostics and therapeutics. This review aims to examine the full spectrum of tumor-EV studies and provide a comprehensive foundation to enhance the field. The topics which are discussed and scrutinized in this review encompass isolation techniques and how these issues need to be overcome for EV-based diagnostics, EVs and their roles in cancer biology, biomarkers for diagnosis and monitoring, EVs as vaccines, therapeutic targets, and EVs as drug delivery systems. We will also examine the challenges involved in EV research and promote a framework for catalyzing scientific discovery and innovation for tumor-EV-focused research.
EFFICACY, SAFETY AND TOLERABILITY OF THE 5-LIPOXYGENASE-ACTIVATING PROTEIN INHIBITOR AZD5718 IN PATIENTS WITH RECENT MYOCARDIAL INFARCTION: A PHASE 2A STUDY (FLAVOUR)
Authors: Eva Prescott, Oskar Angerås, David Erlinge, Erik L. Grove, Marja Hedman, Lisette Jensen, John Pernow, Antti Saraste, Axel Åkerblom, Anna Rudvik, Eva-Lotte Lindstedt, Pavlo Garkaviy, Li-Ming Gan, Anders Gabrielsen
Journal: Journal of the American College of Cardiology (2021)