tbuckley/cabot-search huggingface dataset:
Diabetes and hypertension
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pharmacokinetics of tissue-type plasminogen activator during acute myocardial infarction in men. Effect of a prostacyclin analogue.
Authors: D MKerins, LRoy, SKunitada, AAdedoyin, G AFitzGerald, D JFitzgerald
Journal: Circulation (1992)

BACKGROUNDCoronary reocclusion complicates the thrombolytic therapy of acute myocardial infarction despite the routine use of aspirin. This is consistent with experimental studies demonstrating that multiple agonists, in addition to thromboxane A2, mediate the platelet activation underlying reocclusion. Consequently, a more potent antiplatelet therapy with a broader spectrum of activity than aspirin may be required in this setting. Prostacyclin and its more stable analogue, iloprost, inhibit platelet aggregation to all known agonists and exert an additional effect over aspirin alone. Experiments in animal models have demonstrated, however, that iloprost increases the clearance of tissue-type plasminogen activator (t-PA) and impairs thrombolysis in vivo. This study examines whether a similar interaction occurs in humans.METHODS AND RESULTSTwelve patients with acute myocardial infarction received t-PA intravenously, 60 mg in the first hour and a maintenance infusion of 13.3 mg/hr for 3 hours. Patients were ...
Prostacyclin-induced acute pulmonary vasodilation in primary pulmonary hypertension.
Authors: L JRubin, B MGroves, J TReeves, MFrosolono, FHandel, A ECato
Journal: Circulation (1982)

To evaluate the effects of prostacyclin (prostaglandin I2) on pulmonary vascular tone in primary pulmonary hypertension (PPH), we performed right-heart catheterization on seven patients with PPH and made hemodynamic measurements before and after infusing incremental doses of prostacyclin. In maximal doses of 2-12 mg/kg/min (mean 5.7 +/0 3.1 ng/kg/min), prostacyclin reduced mean pulmonary arterial pressure from 62 +/- 15 to 55 +/- 16 mm Hg (p less than 0.05) and total pulmonary resistance from 17.1 +/- 8.7 to 9.7 +/- 5.9 units (p less than 0.005), and increased cardiac output from 4.22 +/- 1.64 to 6.57 +/- 2.04 l/min (p less than 0.01). Heart rate increased from 83 +/- 13 to 94 +/- 11 beats/min (p = 0.1) and mean systemic arterial pressure decreased from 90 +/- 12 to 77 +/- 4 mm Hg (p = 0.055). Three patients who received a continuous infusion of prostacyclin for 24-48 hours had sustained reductions in total pulmonary resistance during the infusion period. These data demonstrate that prostacyclin can incre...
Parachute accessory anterior mitral valve leaflet causing left ventricular outflow tract obstruction. Report of a case with emphasis on the echocardiographic findings.
Authors: PCooperberg, SHazell, P GAshmore
Journal: Circulation (1976)

A case of left ventricular outflow tract obstruction caused by a parachute accessory anterior mitral valve leaflet is presented. The abnormality was detected in an asymptomatic patient by systolic murmur and thrill and was demonstrated by echocardiography, as well as by cardiac catheterization and surgery. These findings are presented. Several previously reported cases of a similar nature are reviewed. An identical case was not found in the English literature.
Adaptive immunity at the crossroads of autophagy and metabolism
Authors: Shree Padma Metur, Daniel J. Klionsky
Journal: Cellular and Molecular Immunology (2021)

Abstract The function of lymphocytes is dependent on their plasticity, particularly their adaptation to energy availability and environmental stress, and their protein synthesis machinery. Lymphocytes are constantly under metabolic stress, and macroautophagy/autophagy is the primary metabolic pathway that helps cells overcome stressors. The intrinsic role of autophagy in regulating the metabolism of adaptive immune cells has recently gained increasing attention. In this review, we summarize and discuss the versatile roles of autophagy in regulating cellular metabolism and the implications of autophagy for immune cell function and fate, especially for T and B lymphocytes.
Regulation of the endothelial cell urokinase-type plasminogen activator receptor. Evidence for cyclic AMP-dependent and protein kinase C-dependent pathways.
Authors: D JLanger, AKuo, KKariko, MAhuja, B DKlugherz, K MIvanics, J AHoxie, W VWilliams, B TLiang, D BCines
Journal: Circulation Research (1993)

Binding of urokinase-type plasminogen activator (u-PA) to specific receptors (u-PAR) on the surface of endothelial cells contributes to the regulation of plasmin-dependent processes such as fibrinolysis and angiogenesis. We studied the effect of raising intracellular levels of cyclic AMP (cAMP) and/or activating protein kinase C on the expression of u-PAR in cultured human umbilical vein endothelial cells (HUVEC). Incubation of HUVEC with forskolin stimulated a time- and concentration-dependent increase in the expression of u-PAR, measured both by an increase in the specific binding of radiolabeled single-chain u-PA (scu-PA) and by increased binding of anti-u-PAR antibodies. Maximal increase in u-PAR expression (81 +/- 11% above control, n = 11) was not associated with a change in receptor affinity for scu-PA when HUVEC were incubated for 20 hours at 37 degrees C with 50 microM forskolin. Receptor induction by forskolin was inhibited when HUVEC were preincubated with deoxyadenosine monophosphate (DAM), an...
Insulin Resistance and Hyperinsulinemia Are Related to Plasma Aldosterone Levels in Hypertensive Patients
Authors: GianLuca Colussi, Cristiana Catena, Roberta Lapenna, Elisa Nadalini, Alessandra Chiuch, Leonardo A. Sechi
Journal: Diabetes Care (2007)

Perciaccante et al. (1) commented on our article (2) and underlined the relevance that an activated autonomic nervous system might have as a potential link between insulin resistance and hypertension. The possibility that sympathetic hyperactivity contributes to the prohypertensive action of insulin resistance and hyperinsulinemia …
Diagnostic efficiency of troponin T measurements in acute myocardial infarction.
Authors: H AKatus, ARemppis, F JNeumann, TScheffold, K WDiederich, GVinar, ANoe, GMatern, WKuebler
Journal: Circulation (1991)

BACKGROUNDThe present study was designed to evaluate the efficiency of a newly developed troponin T enzyme immunoassay for the detection of acute myocardial infarction.METHODS AND RESULTSThe study comprised 388 patients admitted with chest pain and suspected myocardial infarction and 101 patients with skeletal muscle damage and additional suspected myocardial cell damage. Troponin T was elevated to more than twice the analytical sensitivity of the assay (0.5 microgram/l) in all patients with non-Q wave (range, 1.2-5 micrograms/l) and Q wave infarction (range, 3-220 micrograms/l). Troponin T appeared in serum as early as 3 hours after onset of pain in 50% of the patients and remained elevated in all patients for more than 130 hours, revealing release kinetics of both free cytosolic and structurally bound molecules. The diagnostic efficiency of troponin T was superior to that of creatine kinase-MB (98% versus 97%) and remained at 98% until 5.5 days after admission, if patients with unstable angina were excl...
Evaluation of bioprosthetic valve-associated thrombus in ventricular assist device patients.
Authors: W RWagner, P CJohnson, R LKormos, B PGriffith
Journal: Circulation (1993)

BACKGROUNDThromboembolic events may be related to thrombotic deposition on prosthetic valves. In a left ventricular assist device (LVAD) that contains two porcine pericardial bioprosthetic valves in addition to significant associated biomaterial placement, this may be particularly true. Thrombotic deposits on valves removed from LVADs at autopsy or heart transplantation were scored to determine (1) the nature and location of valvular deposition, (2) whether deposition was related to thromboembolic events, (3) correlations between deposition and patient hemodynamic and coagulation parameters, and (4) implant time dependency.METHODS AND RESULTSNovacor LVADs were implanted in 23 patients as a bridge to transplantation for 1 to 303 days. Photographs of the concave (downstream) and convex (upstream) side of the inflow and outflow valve were made at explant and later scored for (1) total thrombus area (10 = equivalent of cusp area), (2) percent of cusp area occupied by solid thrombus, (3) thrombus color (10 = d...
Coronary vasoconstriction after percutaneous transluminal coronary angioplasty is attenuated by antiadrenergic agents.
Authors: LGregorini, JFajadet, GRobert, BCassagneau, MBernis, JMarco
Journal: Circulation (1994)

BACKGROUNDVasoconstriction occurs after percutaneous transluminal coronary angioplasty (PTCA) along the dilated vessel. The vasomotor changes, initiated by the mechanical stretch of the stenotic region, are thought to be due to various mechanisms but whether the sympathetic nervous system plays a role in this phenomenon remains unknown.METHODS AND RESULTSQuantitative angiography (ARTREK) was performed in 45 patients undergoing an epicardial vessel PTCA for a stenosis of 76 +/- 1% (1) in basal conditions, (2) after PTCA, and (3) 30 minutes after PTCA (vasoconstriction). In 14 control patients, the same measurements were obtained up to 60 minutes after PTCA. Coronary diameters were measured along the PTCA vessel at the narrowest stenosis level and at a level peripheral to stenosis. In 36 patients two diameters were also measured at a proximal segment and at a distal segment along a nonmanipulated vessel. Thirty minutes after PTCA the dilated segment underwent a -31 +/- 2% (mean +/- SEM, ANOVA, P < .05) redu...
Hypertension reduces the number of beta-adrenergic receptors in rat brain microvessels.
Authors: M SMagnoni, HKobayashi, ACazzaniga, FIzumi, P FSpano, MTrabucchi
Journal: Circulation (1983)

Beta-adrenergic receptor function was measured in cerebral microvessels of spontaneously and DOCA-salt hypertensive rats using 125I-iodohydroxybenzylpindolol (IHYP). Both in genetic and in experimental hypertension, a significant decrease in the number of beta-receptor sites was observed, without receptor affinity changes. These results suggest that alterations of central adrenergic regulation of small vessels may participate in the pathogenetic mechanisms leading to the development of the central hypertensive disease.
Association of Acupuncture and Acupressure With Improved Cancer Pain—Reply
Authors: Yihan He, Brian H. May, Haibo Zhang
Journal: JAMA Oncology (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Effects of isoproterenol on bradycardia-dependent intra-His and left bundle branch blocks.
Authors: L DSuárez, AKretz, J AAlvarez, J MMartinez, A MPerosio
Journal: Circulation (1981)

The electrophysiologic study of a patient with a history of fainting showed first- and second-degree Mobitz type I intraatrial and intra-His (IH) bundle blocks. Tachycardia and bradycardia-dependent IH block and bradycardia-dependent left bundle branch block were also present. Bradycardia-dependent block was probably caused by slight hypopolarization plus a slow rising slope of phase 4 depolarization and a shift of the threshold potential toward zero. Two months later a second electrophysiologic study was performed before, during and after administration of i.v. isoproterenol (IP). Shortening of atrium-His (AH1) and IH (H1H2) conduction time during faster heart rates caused by IP infusion may be related to its hyperpolarizing effect. Simultaneously, a shifting to the left of both bradycardia-dependent IH and left bundle branch block ranges was recorded during vagally induced cardiac slowing. These findings suggest that IP produces an increase in the slope of phase 4 depolarization of the His bundle and le...
Response to Comment on Li et al. Visual Inspection of Chromatograms Assists Interpretation of HbA1c: A Case Report. Diabetes Care 2018;41:1829–1830
Authors: Qianrui Li, Yuling Xiao, Anoop Dinesh Shah, Sheyu Li
Journal: Diabetes Care (2018)

We thank Li et al. (1) for their interest in our case report (2), which emphasized the value of visual inspection of chromatograms in clinical practice to assist interpretation of HbA1c.

For consistency and comparability with the first and only available report, by Wajcman et al. in 1992 (3), we presented the identified mutation as c.242T>A, p.Leu81His (rs33936967), without including the translational initiation codon in variant sequence numbering. According to the latest nomenclature recommendations of the Human Genome Variation Society in 2007 (4), starting with number 1 at the A of the ATG for nucleotides and at the methionine encoded by the …
The effect of nitroglycerin on forearm arterial distensibility.
Authors: HSmulyan, SMookherjee, R AWarner
Journal: Circulation (1986)

Nitroglycerin acts, in part, to reduce arterial impedance, and thus left ventricular work. The reduction in arterial impedance is largely attributable to a fall in systemic vascular resistance, but may also be due to an increased distensibility of the arterial tree. In this study, volume distensibility of forearm arteries was calculated from measurements of pulse-wave velocity before and during intravenous nitroglycerin infusion. Since a fall in blood pressure itself increases arterial distensibility, the induced blood pressure change was controlled as a variable by repeating the measurements with the subject's forearm in a plastic cylinder and repeating the measurements at a variety of altered cylinder pressures. At every studied pressure, nitroglycerin infusion increased forearm arterial distensibility, demonstrating another way in which nitroglycerin reduces left ventricular afterload. Since the pulsatile portion of cardiac work is approximately 10% of total work, the magnitude of this nitroglycerin ef...
Baroreceptor reflex control of arterial hemodynamics in the dog.
Authors: R HCox, R JBagshaw
Journal: Circulation Research (1975)

The regional differentiation of carotid sinus control of arterial pressure-flow relationships was studied in chloralose-anesthetized dogs. Simulatneous pressure-flow measurements were made in the ascending aorta, the celiac artery, the cranial mesenteric artery, the renal artery, and the femoral artery. The carotid sinuses were bilaterally isolated and perfused with pulsatile pressure. The open-loop reflex gain was not symmetrical about and was maximum at pressures below the closed loop operating point pressure. Changes in both peripheral resistance and cardiac output contributed significantly to the open-loop gain with the former predominating. Aortic impedance for frequencies above 3 Hz was at a minimum at the closed-loop operating point and increased for both higher and lower values of carotid sinus pressure. For the frequency range from 3 to 9 Hz, regional impedance in all of the beds varied inversely with carotid sinus pressure. The sensitivity of the various beds to changes in carotid sinus pressure...
Leukotriene B4 mediates shear rate-dependent leukocyte adhesion in mesenteric venules.
Authors: KBienvenu, JRussell, D NGranger
Journal: Circulation Research (1992)

Previous studies have demonstrated that low shear rates promote leukocyte adherence to microvascular endothelium in postcapillary venules. The objective of this study was to determine whether an accumulation of inflammatory mediators such as platelet activating factor and leukotriene B4 is responsible for shear rate-dependent leukocyte-endothelial cell adhesion. Postcapillary venules (25-39 microns in diameter) in cat mesentery were studied by intravital microscopy. Venular wall shear rate was varied over a wide range by graded occlusion of the mesenteric artery. Red blood cell velocity, vessel diameter, leukocyte rolling velocity, and the numbers of rolling and adherent leukocytes were measured at each shear rate. In one series of experiments, shear rate-dependent leukocyte adherence was monitored at different superfusion rates (1.0 and 2.5 ml/min). At the lower superfusion rate, the number of adherent leukocytes was significantly higher at any given shear rate when compared with results obtained at the ...
Imaging experimental myocardial infarction with indium-111-labeled autologous leukocytes: effects of infarct age and residual regional myocardial blood flow.
Authors: M LThakur, AGottschalk, B LZaret
Journal: Circulation (1979)

The external imaging patterns and the kinetics of infiltration of indium-111 labeled polymorphonuclear leukocytes (PMNs) occurring in the course of the inflammatory response associated with myocardial infarction were studied in dogs subjected to closed-chest anterior wall infarction. The effects of infarct age and regional residual myocardial blood flow upon PMN infiltration were investigated and quantified, and the capacity of indium-111 PMNs to image the experimental infarction was evaluated qualitatively. The epicardial accumulation of indium-111 PMNs occurred primarily in infarct zones with residual blood flow of 0.6 times normal and was maximal (14.8 +/- 3.8 times normal) in the lowest blood flow zone (less than 0.1 times normal). PMN accumulation in the endocardial infarct zones occurred in the regions with blood flow less than 0.6 times normal and was maximal (26.8 +/- 4.9 times normal) in the lowest blood flow zone. However, contrary to the maximal epicardial infiltration period, which occurred wi...
Endoscopic Removal of a Migrated Gastric Band
Authors: F de Sousa Damião, C Noronha Ferreira, F Nogueira, C Chiado, A Chiado, L Carrilho Ribeiro, J Coutinho, R Tato Marinho
Journal: Endoscopy (2021)

A 57-year-old female patient with grade III obesity (BMI 41.7kg/m2) underwent gastric band implantation in 2009. She achieved a minimum weight of 89 kg (BMI 32.3kg/m2). In 2017, she developed weight regain and recurrent port-site infections. Gastroduodenal endoscopy revealed sub-total intragastric band migration and a terminal esophageal fistula. A metallic wire was introduced through the opening between the cardia and the migrated band within the gastric cavity and recovered through the opposite opening with forceps. The band was cut using the metallic wire and a specific lithotripter-type device, following which, the sectioned gastric band was removed using a polypectomy snare.
Endoscopic Submucosal Dissection for Barrett’S Related Neoplasia in the Netherlands: Results of a Nationwide Cohort of 130 Cases
Authors: EPD Verheij, SN van Munster, EA Nieuwenhuis, L van Tilburg, J Offerhaus, SL Meijer, LAA Brosens, BLAM Weusten, A Alkhalaf, BE Schenk, EJ Schoon, WL Curvers, SEM v/d Ven, WB Nagengast, MHMG Houben, JJGHM Bergman, AD Koch, RE Pouw
Journal: Endoscopy (2021)

Aims The use of endoscopic submucosal dissection (ESD) is gradually expanding for treatment of neoplasia in Barrett’s esophagus (BE). We aimed to report the outcomes of all ESDs for BE neoplasia performed in expert centers in the Netherlands.
Dissociation between epicardial and transmural function during acute myocardial ischemia.
Authors: K PGallagher, M CStirling, MChoy, C ASzpunar, R AGerren, M JBotham, J HLemmer
Journal: Circulation (1985)

The relationship between epicardial and transmural function (measured with sonomicrometers) was examined in 13 anesthetized open-chest dogs. Systolic wall thickening was used as a standard of integrated transmural function to compare with epicardial function measured as segment shortening parallel to surface fibers. Three levels of coronary inflow restriction were produced by using decrements in systolic wall thickening as an index of changes in the transmural distribution of myocardial blood flow (microspheres) in myocardium perfused by the left anterior descending artery (anterior-apical group, n = 7) or circumflex artery (posterior-basal group, n = 6). Levels 1 and 2 were characterized by reductions in systolic wall thickening of 35% and 80%, respectively, and marked decreases in deep myocardial blood flow. In the subepicardium, myocardial blood flow was minimally affected at levels 1 and 2 and there was no change in posterior-basal epicardial segment shortening, but anterior segment shortening decreas...
96O Camrelizumab or placebo plus carboplatin and paclitaxel as first-line treatment for advanced squamous NSCLC (CameL-sq): A randomized, double-blind, multicenter, phase III trial
Authors: C. Zhou, S. Ren, J. Chen, X. Xu, Y. Cheng, G. Chen, Y. Pan, Y. Fang, Q. Wang, Y. Huang, W. Yao, R. Wang, X. Li, W. Zhang, Y. Zhang, S. Hu, R. Guo, Z. Yang, L. Wang
Journal: Journal of Thoracic Oncology (2021)
Suppression of protein degradation in progressive cardiac hypertrophy of chronic aortic regurgitation.
Authors: N MMagid, J SBorer, M SYoung, D CWallerson, CDeMonteiro
Journal: Circulation (1993)

BACKGROUNDThe heart adapts to the volume overload of aortic regurgitation with dilation and hypertrophy. The development of left ventricular hypertrophy at the protein level is a dynamic process resulting from an imbalance between cardiac protein synthesis and degradation. The objective of the present study was to determine in vivo the relative contributions of cardiac protein synthesis and degradation to the progressive hypertrophy that occurs in response to chronic aortic regurgitation and to compare these with responses earlier in the course of this stress.METHODS AND RESULTSContinuous intravenous infusions of [3H]-leucine were administered 3 days and 1 month after surgical induction of aortic regurgitation and sham operation in rabbits. Total cardiac protein and myosin heavy chain fractional synthesis rates were obtained by analysis of plasma and protein hydrolysate data using [14C]-dansyl chloride assays. Left ventricular growth rates were determined from serial echocardiographic and postmortem left ...