tbuckley/cabot-search huggingface dataset:
Commentary
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Suction Blisters
Authors: Kimberly M. Vella, Irene Lara-Corrales, Brij Kishore Rai, Vinay Kukreti
Journal: JAMA Dermatology (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy
Authors: Yoshihiro Otani, Ji Young Yoo, Cole T. Lewis, Samantha Chao, Jessica Swanner, Toshihiko Shimizu, Jin Muk Kang, Sara A. Murphy, Kimberly Rivera-Caraballo, Bangxing Hong, Joseph C. Glorioso, Hiroshi Nakashima, Sean E. Lawler, Yeshavanth Banasavadi-Siddegowda, John D. Heiss, Yuanqing Yan, Guangsheng Pei, Michael A. Caligiuri, Zhongming Zhao, E. Antonio Chiocca, Jianhua Yu, Balveen Kaur
Journal: Clinical Cancer Research (2022)

Abstract Purpose: Oncolytic herpes simplex virus-1 (oHSV) infection of brain tumors activates NOTCH, however the consequences of NOTCH on oHSV-induced immunotherapy is largely unknown. Here we evaluated the impact of NOTCH blockade on virus-induced immunotherapy. Experimental Design: RNA sequencing (RNA-seq), TCGA data analysis, flow cytometry, Luminex- and ELISA-based assays, brain tumor animal models, and serum analysis of patients with recurrent glioblastoma (GBM) treated with oHSV was used to evaluate the effect of NOTCH signaling on virus-induced immunotherapy. Results: TCGA data analysis of patients with grade IV glioma and oHSV treatment of experimental brain tumors in mice showed that NOTCH signaling significantly correlated with a higher myeloid cell infiltration. Immunofluorescence staining and RNA-seq uncovered a significant induction of Jag1 (NOTCH ligand) expression in infiltrating myeloid cells upon oHSV infection. Jag1-expressing macrophages further spread NOTCH activation in the tumor microenvironment (TME). NOTCH-activated macrophages increased the secretion of CCL2, which further amplified myeloid-derived suppressor cells. CCL2 and IL10 induction was also observed in serum of patients with recurrent GBM treated with oHSV (rQnestin34.5; NCT03152318). Pharmacologic blockade of NOTCH signaling rescued the oHSV-induced immunosuppressive TME and activated a CD8-dependent antitumor memory response, resulting in a therapeutic benefit. Conclusions: NOTCH-induced immunosuppressive myeloid cell recruitment limited antitumor immunity. Translationally, these findings support the use of NOTCH inhibition in conjunction with oHSV therapy.
The Last Goodbye
Authors: Dzvinia Orlowsky
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 17163: <i>Nox4</i> Deletion Attenuates Age-Associated Vascular Inflammation and Atherosclerosis Burden in Hyperlipidemic Mice by Modulating Macrophage Phenotype
Authors: Aleksandr E Vendrov, Andrey Lozhkin, Nageswara R Madamanchi, Marschall S Runge
Journal: Circulation (2018)

Introduction: Increased vascular reactive oxygen species (ROS) levels and chronic inflammation are hallmarks of vascular aging. We previously reported that expression of NOX4 NADPH oxidase increases with age in mouse and human arteries and correlates with inflammatory cytokine secretion and atherosclerotic lesion progression. Hypothesis: To determine whether NOX4 promotes atherosclerosis in aging, we assessed vascular inflammation and atherosclerosis burden in Nox4 -/- / Apoe -/- and Apoe -/- mice. Results: Aortic atherosclerotic lesion area was not different between 5-month old (young) Nox4 -/- / Apoe -/- and Apoe -/- mice fed a Western diet for 3 months. Lesion area increased significantly in 16-month old (aged) compared with young mice but was 51% lower in Nox 4 -/- / Apoe -/- versus Apoe -/- mice (n=12, P &lt;0.0001). Immunofluorescence analysis of aorta transverse sections showed 30% lower ROS levels and significantly reduced expression of inflammatory cytokines - CCL2 and IL6 - in atherosclerotic lesions of aged Nox4 -/- / Apoe -/- versus Apoe -/- mice. Flow cytometry analysis of atherosclerotic aortas showed significantly higher number of CD11b + macrophages in the lesions of aged Apoe -/- versus Nox4 -/- /Apoe -/- mice. However, the number of M1 pro-inflammatory macrophages (CD38 + ) was not different, whereas percentage of M2 macrophages (Egr2 + ) was significantly higher in aged Nox4 -/- Apoe -/- versus Apoe -/- mice (46% vs. 33%, respectively). In addition, Nox4 deletion increased the ratio of M2/M1 macrophages in the atherosclerotic aortas from aged Apoe -/- mice (0.56 and 0.43 in Nox 4 -/- / Apoe -/- and Apoe -/- , respectively). Macrophages isolated from Nox4 -/- mice showed lower number of M1 cells after IFNγ+LPS treatment and higher number of M2 cells after IL4 treatment versus macrophages from the wild-type. Furthermore, wild-type macrophages showed significantly higher secreted IL1β levels after IFNγ+LPS treatment versus macrophages from Nox4 -/- mice. Conclusions: These data suggest that increased vascular NOX4 levels in aged Apoe -/- mice promote a proinflammatory environment, enhancing plaque macrophage accumulation and skewing polarization to M1 phenotype resulting in inflammasome activation and atherosclerotic lesion expansion.
TCT-282 Long Term Outcomes of TAVR on Paradoxical Low Flow Low Gradient Severe Aortic Stenosis
Authors: Mohamad Kabach, Abdulah Alrifai, Jesus Pino Moreno, Pradeep Dayanand, Edwin Grajeda, Lawrence Lovitz, Mark Rothenberg, Roberto J. Cubeddu, Cristiano Faber, Marcos Nores, Zaher Fanari
Journal: Journal of the American College of Cardiology (2017)
Unraveling the genomic basis of congenital heart disease
Authors: Dawood Darbar
Journal: Journal of Clinical Investigation (2021)

The genetic, epigenetic, and environmental etiologic basis of congenital heart disease (CHD) for most heart anomalies remains unexplained. In this issue of the JCI, Lahm et al. performed the largest genome-wide association study (GWAS) to date of European individuals with CHD and clinical subtypes. The comprehensive meta-analysis included over 4000 patients and 8000 controls and uncovered common genetic variants that associated with cardiac anomalies. Lahm and colleagues performed single-cell analysis of induced pluripotent stem cells and heart cells, revealing a role for MACROD2, GOSR2, WNT3, and MSX1 in the developing heart. This study advances our understanding of the genetic basis of common forms of CHD.
Vascular deposition of monosodium urate crystals in gout: analysis of cadaveric tissue by dual‐energy computed tomography and compensated polarizing light microscopy
Authors: Nicola Dalbeth, Mariam Alhilali, Peter Riordan, Ravi Narang, Ashika Chhana, Sue McGlashan, Anthony Doyle, Mariano Andres
Journal: Arthritis & Rheumatology (2022)

Disclosure Form Appendix: Supporting Information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Trial of Three Rounds of Mass Azithromycin Administration for Yaws Eradication
Authors: Lucy N. John, Camila G. Beiras, Wendy Houinei, Monica Medappa, Maria Sabok, Reman Kolmau, Eunice Jonathan, Edward Maika, James K. Wangi, Petra Pospíšilová, David Šmajs, Dan Ouchi, Iván Galván-Femenía, Mathew A. Beale, Lorenzo Giacani, Bonaventura Clotet, Eric Q. Mooring, Michael Marks, Martí Vall-Mayans, Oriol Mitjà
Journal: New England Journal of Medicine (2022)

subspecies
Reconstruction of the left anterior descending coronary arery. Proximal ein bypass graft and distal gas endarterectomy
Authors: H. C. Urschel
Journal: JAMA (1971)

A combination of proximal vein bypass graft and distal (CO2) gas endarterectomy for revascularizing a diffusely and totally obstructed left anterior descending coronary artery was successfully performed in five patients. This technical improvement provides immediate blood flow in an artery not previously considered amenable to surgical reconstruction.
US and non US outcomes are similar for patients with cardiogenic shock: A report from the SHOCK trial Venu Menon, Jacques Col, Lynn A. Sleeper, Mark Menegus, Christopher E. Buller, John French, Mark Porway, Harvey D. White, John G. Webb, Jean Boland, Philip Aylward, Judith S. Hochman. St. Luke's-Roosevelt Hospital Center, New York, NY
Journal: Journal of the American College of Cardiology (2001)
TCT-671 Clinical impact of periprocedural myocardial infarction according to various definitions in patients underwent percutaneous coronary intervention with drug eluting stent
Authors: Yong-Hoon Yoon, Sang Yong Om, Hanbit Park, Minsoo Kim, Sang-Cheol Cho, Osung Kwon, Ungjeong Do, Kyusup Lee, Do-yoon Kang, Cheol Hyun Lee, Pil Hyung Lee, Jung-Min Ahn, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park
Journal: Journal of the American College of Cardiology (2017)
Leads from the MMWR
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NERVOUS DYSPEPSIA.
Authors: HENRY M. LYMAN
Journal: JAMA (1897)

<h3>Gentlemen:</h3> —You have recently had opportunities for witnessing the effects of inflammation of the mucous coat of the stomach in several patients who have exhibited, with varying degrees of severity, the symptoms of acute and chronic gastritis. This morning I wish to call your attention to a case that illustrates another form of gastric disturbance—nervomuscular dyspepsia. It has been taught by the dominant school of pathologists that such disturbances of digestion are always due to catarrhal gastroenteritis. But the opinion has long been held, and is gaining ground, that in certain cases the disorder of digestion is dependent upon alterations in the nervous system, and that inflammation takes little or no part in its causation. This is apparently true of the gastric crises of tabes dorsalis; though, in default of an autopsy, it is always possible to imagine the existence of a latent inflammation that is only prominent during a
Sacroiliac Gout
Authors: Stephen E. Malawista
Journal: JAMA (1965)

One patient had acute, recurrent, sacroiliac gouty arthritis, and two others had clinically inactive, tophaceous involvement of the sacroiliac joint. In a retrospective roentgenographic study, changes characteristic of gout were found in the sacroiliac joints of seven of 95 gouty patients. Equivocal changes were found in an additional five gouty patients. Involvement was found only in patients in whom other manifestations of gout had been present for many years. Gout of the axial skeleton appears to be more frequent than is commonly thought.
Transatlantic trip of marrow donor failed to help infant
Authors: E. R. Gonzalez
Journal: JAMA (1981)

Bone marrow transplantation still offers a fighting chance to children with the autosomal recessive form of osteopetrosis (marble bone disease). Sadly, the first child to receive a transplant from an unrelated donor died recently at Rainbow Babies' and Children's Hospital in Cleveland. But his death occurred before engraftment had had a chance to take place and was not donor related, says Peter F. Coccia, MD, acting director of pediatric hematology-oncology at the hospital. Coccia, who is also associate professor of pediatrics at Case Western Reserve University School of Medicine, Cleveland, told<i>JAMA</i>MEDICAL NEWS that a high fever developed in the 10-month-old boy five days after he received an infusion of processed bone marrow from an adult female donor who made a highly publicized trip to Cleveland from London for the transplant. The child was given antibiotics, which did not help his condition. Presumably, the cause of death was an
Improved cGMP generation correlates to hemodynamic improvement in heart failure patients after 21 days treatment with the ET-A receptor antagonist LU135252 Jan Monti, Sebastian Philipp, Michaela Scheuermann-Freestone, Thomas Langenickel, Thomas Notter, Rainer Dietz, Thomas Luescher, Roland Willenbrock. Franz-Volhard-Clinic, Charite, Humboldt-University, Berlin, Berlin, Germany, Knoll-BASF Pharma, Germany
Journal: Journal of the American College of Cardiology (2001)
Phase II Study of ONC201 in Neuroendocrine Tumors including Pheochromocytoma-Paraganglioma and Desmoplastic Small Round Cell Tumor
Authors: Peter M. Anderson, Matteo M. Trucco, Rohinton S. Tarapore, Stacey Zahler, Stefanie Thomas, Janette Gortz, Omar Mian, Martin Stoignew, Varun Prabhu, Sara Morrow, Joshua E. Allen
Journal: Clinical Cancer Research (2022)

Abstract Purpose: Tumor dopamine-like DRD2 receptor expression is higher in pheochromocytoma-paraganglioma (PC-PG) compared with other cancers. ONC201 is a bitopic DRD2 antagonist with preclinical ONC201 activity in desmoplastic small round cell tumor (DSRCT). Patients and Methods: Patients (N = 30) with neuroendocrine tumors were treated on this investigator-initiated trial (NCT03034200). ONC201 dose and schedule were 625 mg orally weekly in cohorts A (PC-PG) + B (other neuroendocrine tumors) and 625 mg orally on 2 consecutive days each week in cohort C, which included 5 responding patients. The primary endpoint was radiographic response measured using RECIST. Secondary endpoints included progression-free survival, overall survival, and safety. Results: In arm A (n = 10; all PC-PG), 50% (5/10) exhibited a partial response (PR) and 2 additional patients had stable disease (SD) &amp;gt;3 months. Median duration of therapy for arm A patients was 9 months (range: 1.5–33 months) with 5 patients treated &amp;gt;1 year. In arm B (n = 12), there were 1 PR (DSRCT) and 2 SD (DSRCT; neuroblastoma) &amp;gt;3 months. Median duration of therapy in arm A was 18 months (range: 1–33 months) and arm B was 3 months (range: 1.5–33 months). Arm C PC-PG (N = 8) showed 1 PR and 7 SD at 3 months, with median duration of therapy &amp;gt;10 months. There was no decline in Karnofsky performance status at week 12 for 28 of 30 patients and no dose modification due to treatment-related adverse events. Conclusions: Oral ONC201 was well tolerated in patients with metastatic neuroendocrine tumors and associated with clinical benefit, including tumor responses, particularly in some patients with DSRCT and the majority of patients with PC-PG. See related commentary by Owen and Trikalinos, p. 1748
Epicardial adipose tissue: does it mediate the cardio‐protective effects of sodium–glucose co‐transporter 2 inhibitors in patients with heart failure? Letter regarding the article ‘Impact of epicardial adipose tissue on cardiovascular haemodynamics, metabolic profile, and prognosis in heart failure’
Authors: Michael Doumas, Dimitrios Patoulias, Christodoulos Papadopoulos
Journal: European Journal of Heart Failure (2022)
Error in Figure Caption and Heading
Authors: Alan Remaley, Maureen Sampson
Journal: JAMA Cardiology (2020)

glyceride level samples due to underrecovery of triglyceriderich lipoproteins. 5,6 We agree that our equation needs to be further evaluated in patients with very low LDL-C levels from PSCK9 inhibitor therapy, as patients with low LDL-C levels in our database mostly had hypertriglyceridemia, and the mathematical relationship between the lipid and lipoprotein variables may vary depending on therapy or metabolic state.In our view, given the potential limitations of the various equations for calculating LDL-C levels, including ours, one should also consider non-highdensity lipoprotein cholesterol and/or apolipoprotein B, particularly in high triglyceride levels samples, in making decisions on how to manage patients for cardiovascular disease risk.
Pulmonary Nocardiosis
Authors: Michael C. Bach
Journal: JAMA (1973)

Sulfonamides were ineffective in the treatment of pulmonary nocardiosis in one recipient of a renal homotransplant and produced severe sensitivity reactions precluding their further use in another. Favorable antinocardial and clinical effects were achieved by treatment with erythromycin plus ampicillin in the latter and with minocycline in the former. Selection of appropriate therapy was based on tests for susceptibility of the causative organism to antimicrobial agents, for which suitable inoculum, medium, and incubation period were used.
Multiple Craniofacial Nodules and Plaques Distributed Bilaterally Along Blaschko Lines
Authors: Linlin Bao, Zhaojun Sun, Fang Yang
Journal: JAMA Dermatology (2022)

A male in his late teens presented with asymptomatic congenital papules, plaques, and nodules in a linear bilateral distribution following Blaschko lines on the scalp and face region. What is your diagnosis?
KLONDIKE NOSOLOGY.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Beneficial effects of carvedilol on angiotensin-converting enzyme and renin activities escapes in patients with chronic heart failure Alain Cohen-Solal, Guillaume Jondeau, Philippe Duc, Serge Witchitz, Alain Berdeaux, on behalf of the SYMPOXYDEX study group. Bicetre Hospital, Kremlin Bicetre, France, Beaujon Hospital, Clichy, France
Journal: Journal of the American College of Cardiology (2001)
Poetry and Medicine
Authors: Jon Mukand
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal