tbuckley/cabot-search huggingface dataset:
Abstract 296: Early Mitochondrial Gene Regulation in Pediatric Cardiac Arrest
Authors: Marco M Hefti, Kumaran Senthil, Michael Karlsson, Johannes Ehinger, Constantine D Mavroudis, Vina M Nadkarni, Robert A Berg, Robert M Sutton, Ryan W Morgan, Todd J Kilbaugh
Journal: Circulation (2018)

Introduction: Cerebral mitochondrial dysfunction is thought to play a role in the post-cardiac arrest syndrome, propagating secondary morbidity and mortality after return of spontaneous circulation (ROSC). Hypothesis: Based on our previous studies showing a persistent decrease in oxidative phosphorylation (particularly Complex I) and increased mitochondrial fission in a swine model of in-hospital cardiac arrest, we hypothesized that nuclear and mitochondrial genes related to respiratory function would be downregulated and genes promoting mitochondrial fission would be upregulated four hours post-ROSC. Methods: One-month old piglets were subjected to sham anesthesia (n=5) or asphyxial cardiac arrest (n=6; 7 minutes of asphyxia followed by induction of ventricular fibrillation) and treated with 10-20 minutes of AHA guideline-based CPR followed by four hours of standardized post-arrest management and humane euthanasia. RNA was extracted from flash-frozen sections of cerebral cortex using a QIAsymphony robot and sequenced on an Illumina HiSeq. Reads were aligned to the reference (SusScrofa11.1 and NC_012095) using STAR and quantified using subreads. Normalization and differential expression analysis were performed using DESeq2 with RNA quality, intra-arrest and post-ROSC physiologic variables as covariates. All p values were adjusted for multiple comparisons (Benjamini-Hochberg) with a significance cutoff of 0.05. Results: Compared to sham, cardiac arrest animals demonstrated reduced expression of multiple components of the respiratory chain, including NDUFA5 (2.4-fold, p&lt;0.001) and NDUFC1 (2.0-fold, p=0.02), key components of Complex I. Components of Complex III (UQCRB, UQCRH) and Complex IV (COX1, COX7C, COX7A2, COX7B) were also downregulated. Dynamin-2 (DNM2), which increases mitochondrial fission, was upregulated (2.3-fold, p=0.005). There was also differential expression of inner membrane solute channel expression (SLC44A1, SLC25A48 and SLC25A16). Conclusions: Multiple components of the mitochondrial respiratory chain are downregulated 4 hours post-ROSC in the brain, including key components of Complex I with concurrent upregulation of the mitochondrial fission protein dynamin-2.
Association of Medicaid expansion with racial disparities in timely neoadjuvant chemotherapy (NAC) in muscle-invasive bladder cancer (MIBC).
Authors: Changchuan Jiang, Stuthi Perimbeti, Lei Deng, Karan Jatwani, Arya Roy, Gurkamal S. Chatta, Saby George, Dharmesh Gopalakrishnan
Journal: Journal of Clinical Oncology (2022)

472 Background: Timely initiation of NAC is critical to improve outcomes in MIBC. Medicaid expansion through the Affordable Care Act improved racial disparities in healthcare access for patients with advanced cancers. This study aimed to assess the association of Medicaid expansion with racial disparities in time-to-NAC in MIBC. Methods: This case-control study queried the National Cancer Database for 18-64 years old Black and White adults who were diagnosed with stage II&amp;III bladder cancer and treated with NAC from Jan 1, 2008 to Dec 31, 2018. The primary endpoint was the timely receipt of NAC, defined as initiation within 45 days from the diagnosis of resectable MIBC. Racial disparity was defined as percentage-point (PP) difference for Black vs. White patients, adjusted for age, sex, income level, clinical stage, and year of diagnosis. Results: The study included 5053 patients (7.2% Black, n = 391). In states without Medicaid expansion, Black patients became less likely to receive timely NAC than their White counterparts (2008-2013: Black 59.6% vs White 63.8%, p = 0.53; 2014-2018: Black 47.9% vs White 61.2%, p &lt; 0.01). In contrast, the racial disparity was narrowed in states with Medicaid expansion (2008-2013: Black 35.7% vs White 62.9%, p &lt; 0.01; 2014-2018: Black 53.4% vs White 59.5%, adjusted PP difference -2.4; p = 0.20). The adjusted difference-in-differences estimate revealed a 26.0 PP reduction in racial disparity (95% CI, 8.1%-44.0%; p &lt; 0.01). Conclusions: Medicaid expansion was associated with significant reduction in racial disparity between Black and White patients in the timely receipt of NAC for MIBC.
Cosmetic surgery.
Authors: C E Horton, J E Adamson, R A Mladick, J H Carraway
Journal: BMJ (1974)

~~after the operation.Note the pable spleen.Case 3.was actually in hospital at the time of the acute torsion.The onset of symptoms was dramatic and similar to those of an acute perforation of a peptic-ulcer.The patients were all in obvious pain and looked iMl.Their pulse rates were raised and there was a mild fever.In all cases the abdominal signs were those of peritonitis with the guarding and rebound maximum over the large, hard, fixed tumour.None of the three tumours had the typical shape and consistency of a spleen.McClain and Lebherz suggest the position of the splenic notch.is of diagnostic significace, but in none of the cases described here was a splenic notch palpable.8Bohrer5 quotes a case of Mauro,9 in which a young man with known nalarial splenomegaly presented with an acute abdomen.Nevertheless, on clinical examination the splenic area wags empty, and hence the correct diagnosis of torsion of the spleen was made.Romiti`0 describes a young girl with an acute abdomen who was known to have a palpable spleen from malaria.On examination the spleen was not felt, and here again the correct diagnosis was made.Darle -et al. describe a case from Sweden, very similar to my third case in this paper.In the first case preoperative diagnosis was incorrect.Nevertheless, since then, in all cases with symptoms of an acute abdomen where a mass has 'been felt, the patient has been specifically asked abou-t the presence of an enlarged spleen or of a mass in the left upper quadrant of the abdomen.In the second case, on direct questioning, the patient admitted he had been conscious of an enlarged spleen which on clinical examination could not be palpated in the usual position.In the third case the patient volunteered the in- formation that the mass she had had in her left hypochon- drium had disappeared before being a*ed.Hence in a malarious area it would seem reasonable to suggest that in all acute abdomens where a tumour is palp- able the patient should be asked if he had been aware of an enlarged spleen or had noticed a mass in the left hypo- chondrium.If an enlarged spleen is absent from the left hypochondrium and a tender tumour is felt elsewhere, then the diagnosis is probably acute torsion of the spleen.
Fatal chlormethiazole poisoning in chronic alcoholics.
Authors: J M Horder
Journal: BMJ (1977)

A case of paraproteinaemia associated with leucocytoclastic vasculitis and pyoderma gangrenosum has also been described.;In that case the authors suggested that because of the histological findings the pyoderma gangrenosum could be regarded as a type of leucocytoclastic vasculitis.We may therefore reasonably assume in our case that the EED was associated from the beginning with paraproteinaemia.It is further consistent that the paraproteinaemia was of the IgA type.Most cases of pyoderma gangrenosum with paraproteinaemia are of the IgA type.EED associated with frank or possible myeloma was described some years ago,4 the myeloma being diagnosed four to six years after the EED.The evolution of "benign paraproteinaemia" to malignant gammopathy, if it occurs, could take some years.This was the sequence of events in our case since the myeloma was diagnosed nine years after the appearance of the erythema and five years after the discovery of the paraproteinaemia.
Abstract 181: An Analysis of Worldwide Public Access Defibrillator Usage Since October 2012. Does CPR Prior to Defibrillation Improve Survival Outcomes?
Authors: Hannah Torney, Adam Harvey, Olibhear McAlister, Amy Kernaghan, Laura Davis, David McEneaney, Jennifer Adgey
Journal: Circulation (2018)

Introduction: As outlined by the Chain of Survival, effective cardiopulmonary resuscitation (CPR) and rapid defibrillation are vital to improve survival from sudden cardiac arrest (SCA). Placement of public access defibrillators (PADs) is becoming more common in public spaces, and they are more frequently used by untrained lay-users. The objective of this analysis was to assess the effect of CPR prior to defibrillation, and the success of PAD usage in terms of first shock success and survival to hospital admission. Methods: This dataset was composed of voluntarily submitted demographic information and electronic PAD files collected from October 2012 - June 2018. Summary statistics were calculated, and proportions were determined with 95% confidence intervals (CI) where appropriate. The association between CPR prior to defibrillation and survival was investigated by fitting a logistical model with survival as the dependent variable and CPR as covariate. Results: A total of 2812 PAD events were analyzed. Mean (SD) patient age was 61 (19) years and males comprised 72.5% (1922 of 2650 events where gender was known) of the events reported. The most common locations of SCA were the home (1039, 36.9%), public (719, 25.6%) and medical facility (328, 11.7%). Median (IQR) time to PAD delivery was 5 (3, 11) minutes. Ventricular fibrillation or tachycardia was present in 1010 (35.9%) patients, and 979 received a shock, with 87.2% (95%CI [85.0%, 89.3%]) achieving first shock success. Of the 849 shockable patients for whom survival was known, 565 (66.5%, (95%CI [63.3%, 69.7%]) survived to hospital admission. Survival outcome was known for 2150 patients, and 681 (31.7%, 95%CI [29.7%, 33.69%]) survived to hospital admission. A total of 1649 (58.6%) SCAs were witnessed and 1293 (78.4%) patients received bystander CPR prior to defibrillation. Bystander CPR prior to defibrillation was significantly associated with survival to hospital admission (OR = 2.17, 95%CI [1.69, 2.81], p&lt;0.001). Conclusion: These results suggest that CPR application prior to application of a PAD significantly increases a patient’s chances of surviving to hospital admission. This study did not assess CPR quality, but it is intuitive that good quality CPR would align with higher survival outcomes.
A NURSES' STRIKE.
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Proteomics technologies for cancer liquid biopsies
Authors: Zhiyong Ding, Nan Wang, Ning Ji, Zhe-Sheng Chen
Journal: Molecular Cancer (2022)

Alterations in DNAs could not reveal what happened in proteins. The accumulated alterations of DNAs would change the manifestation of proteins. Therefore, as is the case in cancer liquid biopsies, deep proteome profiling will likely provide invaluable and clinically relevant information in real-time throughout all stages of cancer progression. However, due to the great complexity of proteomes in liquid biopsy samples and the limitations of proteomic technologies compared to high-plex sequencing technologies, proteomic discoveries have yet lagged behind their counterpart, genomic technologies. Therefore, novel protein technologies are in urgent demand to fulfill the goals set out for biomarker discovery in cancer liquid biopsies.Notably, conventional and innovative technologies are being rapidly developed for proteomic analysis in cancer liquid biopsies. These advances have greatly facilitated early detection, diagnosis, prognosis, and monitoring of cancer evolution, adapted or adopted in response to therapeutic interventions. In this paper, we review the high-plex proteomics technologies that are capable of measuring at least hundreds of proteins simultaneously from liquid biopsy samples, ranging from traditional technologies based on mass spectrometry (MS) and antibody/antigen arrays to innovative technologies based on aptamer, proximity extension assay (PEA), and reverse phase protein arrays (RPPA).
Oxygen‐Carrying and Antibacterial Fluorinated Nano‐Hydroxyapatite Incorporated Hydrogels for Enhanced Bone Regeneration
Authors: Baoxuan Huang, Mingjiao Chen, Jia Tian, Yuanhao Zhang, Zhaobo Dai, Jin Li, Weian Zhang
Journal: Advanced Healthcare Materials (2022)

Insufficient oxygen availability in tissue engineering is one of the major factors for the failure of clinical transplantation. One potential strategy to conquer this limitation is the fabrication of spontaneous and continuous oxygen supplying scaffolds for in situ tissue regeneration. In this work, a versatile fluorine-incorporating hydrogel is designed which can not only timely and continuously supply oxygen for mesenchymal stem cells (MSCs) to overcome deficient oxygen before vascularization in scaffolds, but can present a higher antibacterial capability to avoid bacterial infections. The HAp@PDA-F nanoparticles are first prepared and then incorporated with the quaternized and methacrylated chitosan forming CS/HAp@PDA-F by photo-crosslinking. In vitro results indicate that CS/HAp@PDA-F hydrogel has outstanding mechanical performance, moreover, it also has the oxygen-carrying ability to prolong survival ability, enhance proliferation activity, and preserve osteogenic differentiation potency and promote osteogenic-related genes expression of rat bone mesenchymal stem cells (rBMSCs) under hypoxic environment. Furthermore, the CS/HAp@PDA-F hydrogel can inhibit the growth of Staphylococcus aureus and Escherichia coli, providing a good antibacterial activity. Additionally, in vivo experiments demonstrate higher bone volume and bone mineral density, and more new bone tissue generation in CS/HAp@PDA-F group than in CS/HAp@PDA group. These results indicate that the rational design of fluorinated hydrogel possesses a good clinical application prospect for bone regeneration.
Frozen shoulder.
Authors: D Resnick
Journal: Annals of the Rheumatic Diseases (1985)

Pain and rheumatoid arthritis SIR, Gibson and Clark' have indicated that rheuma- tologists may underestimate their patients' desire for pain relief.In their survey 47% of a random sample of patients with rheumatoid arthritis ranked pain relief as the most desirable objective of treatment.We also have been impressed by the knowledge that pain is the major symptom of our patients.We surveyed 250 patients and asked them to rank the importance of treatment related to the relief of four symptoms: pain, stiffness, joint swelling.and disability.The order in which the symptoms were presented to the patients was varied.One hundred and twenty two patients were suffering from rheumatoid arthritis, 53 from degenerative joint disease, and the remainder from a variety of other rheumatic diseases.66% of the rheumatoid patients and 75% of the patients with degenerative joint disease ranked pain as the most important symptom to be treated.Only 22% of rheuma- toid patients and 15% of patients with degenerative joint disease ranked disability as the most important symptom.Stiffness was ranked third by both groups, with 12% and 6% respectively.The patients with rheumatoid arthritis who considered disability to be all important were, in general, patients with end stage disease who had rheuma- toid deformities without active synovitis.One wonders therefore whether the relatively small proportion of patients in Gibson and Clark's survey who ranked pain relief important may have included a large proportion with end stage disease.Although the patients with degenerative joint disease considered similar priorities of treatment, they tended to have greater difficulty in differentiating the symptoms and appeared less dogmatic.The message however remains clear: the success of treatment in the rheumatic diseases needs to be assessed by the relief of the patients' most important symptom -pain.
"OR WHAT'S A HEAVEN FOR?"
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MOTOR NOTES FOR MEDICAL MEN
Authors: H. M. Buist
Journal: BMJ (1914)

bflEDkAL JOUaNAD 105 lhospitals and convalescent lhomes in Austria.It also provides all tlhc first field dressings for the entire army.The following account of the resources of the Austrian Red Cross Society is taken from a speech by Surgeon- General Ritter vou Uriel, late Director-General Austrian
THE POISONING OF A PEOPLE.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
About the Cover...
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nephrology
Authors: Victor E. Pollak
Journal: JAMA (1968)

In France there are several excellent large renal units staffed by teams of physicians representing diverse disciplines relating to the kidney.<i>Nephrology</i>is written by the very able team at the Hôpital Necker in Paris, directed by Jean Hamburger; it appears in its English translation by Anthony Walsh within two years of its publication in France. The book is written by eight authors with nine collaborators. They are physicians whose major responsibilities lie in the areas of clinical nephrology, pathologic anatomy, electron microscopy, biochemistry, physiology, immunology, radioisotopes, and radiology; all are members of the Hôpital Necker renal team. There are additional contributions by Royer in pediatric nephrology. The team approach to renal disease at the Hôpital Necker is clearly manifest in this text, for it has a unity of approach which is most unusual in a book written by many authors. It is a comprehensive but not allinclusive work, and
Association between very to moderate preterm births, lung function deficits, and COPD at age 53 years: analysis of a prospective cohort study
Authors: Dinh S Bui, Jennifer L Perret, E Haydn Walters, Caroline J Lodge, Gayan Bowatte, Garun S Hamilton, Bruce R Thompson, Peter Frith, Bircan Erbas, Paul S Thomas, David P Johns, Richard Wood-Baker, John L Hopper, Peter G Davis, Michael J Abramson, Adrian J Lowe, Shyamali C Dharmage
Journal: The Lancet Respiratory Medicine (2022)
Tracheostomy
Authors: J. D. K. Dawes, J. C. Stoddart
Journal: BMJ (1969)

all the micro-organisms commonly respon- sible for such lesions.We find it surprising that no mention is made in his paper of the genus of anaerobic Gram-negative bacilli, the Bacteroides fusiformis, various species of which have been reported in cerebral abscesses, particularly those occurring in association with chronic infections of the middle ear, respiratory sinuses, and respiratory tract, and in cyanotic congenital heart disease.' 2 The particular importance of the Bacteroides organisms isolated from these abscesses is that they are usually resistant to penicillin.During the past five years in this hospital of approximately 50 patients with cerebral abscesses 11 patients yielded Bacteraides on culture, and of these 10 were Bacteroides fragilis-a species which is highly resistant to penicillin' 4 Treatment of infec- tions due to penicillin-resistant Bacteroides with penicillin in high dosage has usually been unsuccessful ' We therefore suggest that in cerebral abscesses arising from chronic foci or associated with congenital cyanotic heart disease it would be desirable to employ in addition to penicillin an antibiotic such as chloramphenicol, erythromycin, or lincomycin to deal with these penicillin-resistant bacteria.''-We are, etc.,