tbuckley/cabot-search huggingface dataset:
Expectations and quality of life of cancer patients undergoing radiotherapy
Authors: Michael Koller, Wilfried Lorenz, Katja Wagner, Astrid Keil, Diana Trott, Rita Engenhart-Cabillic, Christoph Nies
Journal: Journal of the Royal Society of Medicine (2000)

Expectations, real or false, affect the way patients respond to their illnesses. We assessed therapy-related expectations in relation to global quality of life in 55 cancer patients before and after radiotherapy. Factor analysis indicated that therapy-related expectations come into three broad categories--pain/emotional control, healing and tumour/symptom control. 35 patients expected 'healing' even though curative treatment was intended in only 19 and all patients had been fully informed. The expectation of healing was associated with high quality of life, and the same was true of perception of healing after radiotherapy. In the group as a whole, quality of life was little altered by radiotherapy, but it became substantially worse in those patients who had expected healing but perceived that this had failed, even though physician-assessed Karnofsky status did not change. These findings indicate that the expectation of healing, in cancer patients, is a component of a good global quality of life, whereas more limited expectations (pain control, tumour control) relate to lower quality of life. Patients' expectations deserve further study as a novel approach to improving care.
Abstract 3422: Asymmetric Division of Human Cardiac Progenitor Cells Involves Immortal DNA Strand Cosegregation
Authors: Silvana Bardelli, Claudia Bearzi, Cynthia Carrillo-Infante, Adriana Bastos Carvalho, Domenico D’Amario, Arantxa Gonzalez, Roberto Bolli, David A. D’Alessandro, Robert E. Michler, Federico Quaini, Toru Hosoda, Tiziano Moccetti, Piero Anversa, Jan Kajstura
Journal: Circulation (2008)

The objective of this study was to determine whether asymmetric division of human cardiac progenitor cells (hCPCs) occurs by: random DNA template segregation; selective retention of the old template DNA strand; or a combination of both processes. Myocardial samples were enzymatically dissociated and hCPCs were sorted for the stem cell antigen c-kit. During in vitro expansion, hCPCs were exposed to BrdU for 36 hours to reach a 90% degree of labeling. BrdU-tagged hCPCs were plated at limiting dilution to obtain single cell-derived clones. Sixty clones comprising 10 –125 c-kit-positive hCPCs developed in 7–10 days. In four cases, one single BrdU-bright hCPC was identified while the remaining clonogenic cells were negative for the halogenated nucleotide. In these clones, the number of BrdU-negative hCPCs was 25, 85, 95, and 111. Conversely, in 56 clones hCPCs were uniformly labeled and showed very low levels of BrdU. In a second group of experiments, hCPCs in late-anaphase initial-telophase were identified and the distribution of BrdU in the two clusters of chromosomes was analyzed. In 5% of mitotic cells, three-dimensional reconstruction by confocal microscopy documented that BrdU-labeling was restricted at one pole only of the dividing hCPCs. PCNA which is highly expressed in newly synthesized DNA was restricted to the BrdU-negative chromosomes. In a third set of studies, hCPCs were loaded with quantum dots, cultured for 36 hours in the presence of BrdU and examined 96 hours later. Quantum dots are progressively diluted by cell division independently from the modality of DNA template segregation. Thus, hCPCs with minimal levels of quantum dots and bright BrdU localization were interpreted as replicating cells which retained the old DNA strand. By this approach, 5% hCPCs displayed these two critical properties. The uneven distribution of the cell fate determinants Numb and α-adaptin confirmed that hCPCs underwent asymmetric division. In conclusion, these data support the hypothesis that immortal DNA strand cosegregation participates in asymmetric kinetics of hCPCs although random-segregation of DNA template is the prevailing mechanism of hCPC growth.
Abstract 16389: Molecular Imaging of Vulnerable Plaque With Thrombus-Specific NanoQ Copper Nanocolloids
Authors: Dipanjan Pan, Shelton D Caruthers, Angana Senpan, Mike J Scott, Patrick J Gaffney, Samuel A Wickline, Gregory M Lanza
Journal: Circulation (2011)

Introduction: Sensitive detection of ruptured plaque, the sine qua non of stroke and myocardial infarction, remains an unmet challenge. Previous gadolinium-peptide conjugates lacked clinical effica...
Abstract 176: A Randomized, Double-Blind Multicenter Trial Comparing Vasopressin and Adrenaline in Patients with Cardiac Arrest at the Emergency Department (Preadmission Intravenous Vasopressin, Adrenaline Outcome Trial [PIVOT])
Authors: Marcus E Ong, Ling Tiah, Benjamin S Leong, Elaine C Tan, Victor Y Ong, Elizabeth A Tan, Bee Yen Poh, Pin Pin Pek, Yuming Chen
Journal: Circulation (2011)

Aims Recently, vasopressin has been used in cardiac arrest patients. In human studies on vasopressin, clinical trials have produced conflicting results. We aimed to compare vasopressin and adrenaline in the treatment of cardiac arrest at the Emergency Department (ED). Methods This was a randomised, double-blind, multi-centre, parallel-design clinical trial involving four hospitals. All cardiac arrest patients (confirmed by the absence of pulse, unresponsiveness and apnea) aged above 16 were eligible (age 21 and above for one hospital). The exclusion criteria were traumatic cardiac arrest or contraindicated cardio-pulmonary resuscitation (CPR). Eligible patients were randomly assigned to receive adrenaline (1 mg) or vasopressin (40 IU) in the ED. The primary outcome was survival to hospital discharge (defined as patient discharged alive or survival to 30 days post arrest). Results We recruited 727 eligible patients (adrenaline= 353; vasopressin= 374) whose baseline characteristics in both groups were comparable. After adjustment for race, medical history, bystander CPR and prior adrenaline given, more patients survived to hospital admission with vasopressin (22•2%) than adrenaline (16•7%) (p=0•047, RR=1•43, 95% CI=1•02- 2•04). No significant differences were noted for return of spontaneous circulation. Eight patients (2•3%) from the adrenaline and 11 (2•9%) from the vasopressin group survived to hospital discharge. After adjusting for race, medical history, bystander CPR and previous adrenaline given, there was no significant difference (p=0•274, RR= 1•72, 95% CI=0•65 -4•51). Post hoc analysis suggested improved outcomes for vasopressin in patients with prolonged arrest times. Conclusion Vasopressin seems to improve survival to admission in patients with prolonged cardiac arrest but not long term survival. Further studies on the effect of vasopressin on patients with prolonged arrest are needed. (ClinicalTrials.gov number, NCT00358579 )
Abstract 238: A Pilot Observational Study of Coagulation Function Following Resuscitation From Cardiac Arrest With Rapid Induction of Therapeutic Hypothermia
Authors: Nathan White, Erika Martin, Michael Kurz, Christopher Hogan, Mary Ann Peberdy, Joseph Ornato, Donald Brophy, Kevin Ward
Journal: Circulation (2010)

Introduction: The acute coagulation response to resuscitation from cardiac arrest and how it may be modulated by therapeutic hypothermia (TH) has been identified by the International Liaison Commit...
New Appliances
Authors: K MOGHISSI
Journal: BMJ (1961)

TELEVISION IN THE MEDICAL SCHOOL MBRrn (3) The image orthicon 4.5-in.(11.4-cm.)camera weighed 90 lb.(41 kg.), and needed no extra lighting.It could be used for radiological fluoroscopy without an image intensifier and in the undarkened room.Cost, £3,000-£5,000.(4) Display projector screen for larger audiences: 12 by 9 ft.(3.6 by 2.7 m.) black-and-white screen; cost, £1,000- £5,000; the same-sized colour screen cost £5,000-£12,000.(5) Tele-cine, black-and-white, for recording; cost, £2,000.(6) Tele-recording; (a) video tape; cost, £L5,000£20,000; (b) film; cost, £1,000 upwards.(7) Video tape recorder; cost, £8,000.(8) Colour television; cost, £15,000-£30,000.
Introduction to the Analysis of Drugs and Medicines. An Elementary Handbook for the Beginner.
Authors: Burt Everette Nelson
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Origin of the Human Skeleton: An Introduction to Human Osteology.
Authors: R. Broom
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 5762: Evaluation of Coronary Artery Plaque Tissue Characterization by Cardiac Magnetic Resonance Imaging
Authors: Yasuyo Taniguchi, Tsuyoshi Ishimoto, Sachiyo Iwata, Shinitchiro Yamada, Masahiro Kumada, Akira Shimane, Kazuo Mizutani, Yasue Tsukishiro, Kensuke Matsumoto, Gaku Kanda, Katsunori Okajima, Takatoshi Hayashi, Teishi Kajiya
Journal: Circulation (2008)

Background: In carotid artery, magnetic resonance imaging (MRI) is able to depict the plaque tissue characteristics and the surface status of plaque. In this study, we made a detailed assessment of...
Phase I multicenter study to assess the safety, tolerability, and pharmacokinetics of AZD4877 administered twice weekly in adult patients with advanced solid malignancies
Authors: J. J. Stephenson, N. Lewis, J. C. Martin, A. Ho, J. Li, K. Wu, L. Pace, J. P. Eder, G. K. Schwartz
Journal: Journal of Clinical Oncology (2008)

2516 Background: AZD4877 is a specific and potent inhibitor of the mitotic kinesin Eg5 with cytotoxicity to human tumor cell lines. Eg5 inhibition by AZD4877 is characterized by development of a monopolar (or monoastral) spindle, resulting from inability of cells to separate spindle poles. A weekly dosing schedule of AZD4877 is in clinical trials in solid tumors and leukemia. Twice weekly dosing of AZD4877 was investigated because of preclinical data indicating increased efficacy with greater drug exposure at equivalent doses. Methods: Patients (pts) with refractory solid tumors and preserved organ function were enrolled on this phase I dose-escalation trial. AZD4877 was administered intravenously on Days 1, 4, 8 and 11 of a 21-day cycle. The initial dose was 2mg based on pre-clinical toxicology. A modified Fibonacci dose escalation scheme was used until a maximum tolerated dose (MTD) was achieved. Results: Seventeen pts have been enrolled in 5 cohorts with 16 evaluable for safety and pharmacokinetics. Three pts remain on study. Evaluable pt population tumor types included esophagus, bladder, breast, colong, lung, pancreas and prostate. To date, 38 cycles of therapy have been administered. Three patients were treated in each of the first four cohorts dosed at 2mg, 4mg, 7mg and 11mg without evidence of dose-limiting toxicity (DLT). DLT was grade 4 neutropenia lasting > 4 days in 2/2 pts at the 15 mg dose. The estimated AZD4877 t½ ranged from 7–21 hours (h). Monoaster formation was seen in PMBCs at 6–8 and 24 h post dose at the 11 and 15 mg dose level. Four patients have had radiographically stable disease ranging from 2 to 7+ cycles, the longest in bladder cancer. All other pts had progressive disease. Conclusions: AZD4877 given on a day 1, 4, 8, and 11 schedule every 21 days has a presumptive MTD of 11mg/dose. Neutropenia is the DLT. The t½ is similar to a weekly dosing schedule. Monoaster formation, indicative of Eg5 inhibition in PBMCs, was observed at the 11 and 15 mg dose. AZD4877 should be considered for further exploration either as a single agent or in combination studies. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration AstraZeneca Oncology AstraZeneca LP AstraZeneca Oncology
Marked Hematopoiesis Masquerading Multiple Bone Metastasis in a Lung Cancer Patient With Myelodysplastic Syndrome
Authors: Osamu Imataki, Shumpei Uchida, Kohei Shiroshita, Jun-ichiro Kida, Makiko Uemura
Journal: Clinical Nuclear Medicine (2015)

We diagnosed a 62-year-old man with lung cancer, well-differentiated squamous cell carcinoma, on the right upper lobe and left lower lobe. He had a history of myelodysplastic syndrome and refractory anemia with ringed sideroblasts diagnosed 5 years earlier. The patient's ¹⁸F-FDG PET/CT for the clinical staging of lung cancer revealed accumulations of FDG in multiple bones including the rib bones, which strongly suggested multiple bone metastases. He underwent lobectomies and excision of the right fourth and fifth rib bones. The pathological findings of resected rib bones exhibited hypercellular bone marrow without excess of blasts.
Abstract 19347: Systematic Differences in Left Ventricular Volumes Measured by Cardiac MR and Biplane Echocardiography in Moderate-Severe Mitral Regurgitation.
Authors: Gillian Whalley, Ruvin Gabriel, Andrew Kerr, Yin Hongning, Ai Wei Lee, Brett Cowan, Alistair Young, Ralph Stewart
Journal: Circulation (2010)
Transition from Paediatric to Adult Care: Psychological Principles
Authors: Mandy Bryon, Susan Madge
Journal: Journal of the Royal Society of Medicine (2001)

.Itiswithoutquestion that there should be adult services for people withCF, and these are steadily being developed. At some point ayoung person with CF must move from a child-orientedservice toanadult-focused one.The process ofthistransitionis not, however, clearly deﬁned, and there are widevariations in practice
Infopoints: Improving the use of clinical databases
Authors: N. Black
Journal: BMJ (2002)

This study shows that concerns about compliance with paper diaries are justified. 5Although patients reported high compliance, actual compliance was low and hoarding was common.The excellent compliance achieved with the electronic diary indicates that low compliance was not due to this particular sample or to an overly burdensome protocol.Overall, these results call into question the validity of paper diary records.
Abstract 8264: Exercise Training Improves Cardiac Function and Restores Nuclear Localization of pAKT in Aged Mice
Authors: Hazim El-Haddad, Hunter C Champion, Thomas A Danner, Sandesh S Rao, Thomas J Mulhearn, Azeb Haile, Milena Gebska, Anna Hemnes, Matthew Hager, Matt Breton, Mobusher Mahmud
Journal: Circulation (2011)

Cardiovascular aging is frequently associated with atherosclerosis, hypertension, and vascular stiffening as well as significant functional and molecular changes that result in cardiac hypertrophy and the development of fibrosis. On a functional scale, aerobic exercise is known to induce physiologic hypertrophy and to improve cardiovascular performance. In this study we sought to determine the effectiveness of exercise in aged (24-26 month old) C57/BL6 mice as well as to explore potential mechanisms for any observed cardiovascular improvement. Old and young mice underwent exercise training by swimming for a period of six weeks. At the conclusion of the swim training, hemodynamic and molecular markers of cardiac function in old and young mice were assessed. We show that exercise training results in significant improvement in left ventricular (LV) function in older animals, a significant increase in ejection fraction (EF) and mean stroke work index (MSWI), and an improvement in the time constant of LV relaxation (Tau). Swim training also resulted in a reduction in aging-associated oxidative stress (42 +/-13% reduction in luminol activity when compared to old sedentary, P&lt;0.05). In addition, aging was associated with a significant shift of pAKT from the nucleus to the cytosol and exercise training reversed this process. These findings demonstrate that swimming not only has a beneficial effect on cardiac function in the aged, but can also serve to mediate and even reverse the biological processes associated with age-related cardiovascular changes in the elderly.
Standardization and quality control studies of “real-time” quantitative reverse transcriptase polymerase chain reaction (RQ-PCR) of fusion gene transcripts for residual disease detection in leukemia - A Europe Against Cancer Program Section 5. t(9;22) (q34;q11) with the BCR-ABL M-bcr fusion gene transcript
Authors: Gisela Barbany, C Chillón, M Silva, D de Micheli, E Gotardi, P Evans, F Watzinger
Journal: Leukemia (2003)
Abstract 19815: Staging Atherosclerotic Disease and Vessel Remodeling with [18F]-Sodium Fluoride, a Novel Biomarker of Active Calcification: Sub-study of the Canadian Atherosclerosis Imaging Network (CAIN-2)
Authors: Myra S Cocker, J. David Spence, George Wells, Robert Hammond, Brian McArdle, Rob deKemp, Cheemun Lum, Tigran Karavardanyan, Adebayo Adeeko, Andrew Hill, Sudhir Nagpal, Grant Stotts, Cathy Kelly, Joanne Brennan, Linda Garrard, Murad Alturkustani, Laurel Hammond, Jean DaSilva, Martin Yaffe, Jean-Claude Tardif, Rob Beanlands
Journal: Circulation (2014)

Background:  [18F]-sodium fluoride (NaF) positron emission tomography (PET) uptake may serve as a marker of active calcification. Osteopontin regulates active calcification within plaque. Positive vessel remodeling is a marker of vulnerable plaque.  We hypothesized that active calcification within carotid plaque, as determined by NaF PET/CT uptake, is associated with osteopontin expression and positive vessel remodeling.   Methods:  Eleven patients (69±5 years, 3 females) scheduled for carotid endarterectomy were prospectively recruited for NaF PET/CT imaging of the carotids. The bifurcation of the common carotid was used as the reference point; maximum NaF uptake normalized to blood (tissue to blood ratio - TBR) was measured at every PET slice extending 2 cm above and below the bifurcation.  Using NASCET criteria, cross-sectional vessel area was measured and related to proximal and distal segments, generating a vessel remodeling index (RI) for every PET slice. Regions with a RI ≤ 1.0 were classified as positive remodeling.  Excised plaque was immunostained for osteopontin and whole-slide digitized images were used to quantify osteopontin expression. Pathology was co-registered with PET.   Results:  Immunohistology was available for 8 plaques. As a result of intraplaque clustering, a meta-analysis was performed and demonstrated that NaF uptake was related to intraplaque osteopontin expression (r=0.37, p=0.03) (Figure 1). NaF uptake was greater in regions with positive vessel remodeling (TBR=2.6±0.9 with positive (n=185) vs. 1.6±0.6 (n=46) without positive remodeling, p   Conclusion:  Atherosclerosis is a progressive disease. Along this continuum, we have found that there is inter-plaque variability in calcific activity and NaF uptake correlated with osteopontin expression. NaF uptake is directly related to vessel remodeling. Thus, NaF is a novel biomarker of active calcification and may serve as a tool to stage atherosclerosis.
Herpes Zoster Mimicking Breast Cancer With Axillary Lymph Node Metastasis on PET/CT
Authors: Eun Kyoung Choi, Jin Kyoung Oh, Yong-An Chung
Journal: Clinical Nuclear Medicine (2015)

Herpes zoster is a reactivated varicella-zoster virus infection and demonstrates typical dermatomal distribution. We herein describe a case of a 41-year-old woman with a history of ovarian cancer. Intense hot uptake in the left breast and enlarged ipsilateral axillary lymph nodes were noted on ¹⁸F-FDG PET/CT for adjuvant chemotherapy response evaluation. Blinded to the patient's clinical information, these lesions were interpreted as incidental breast cancer with axillary nodal metastasis. However, clinically she presented with vesicles along the T4 dermatome and palpable enlarged nodes in the left axilla. On 3-month follow-up PET/CT after antiviral treatment, these intense hot uptake areas were no longer visualized.
Insulin sensitivity, measured with euglycaemic-hyperinsulinaemic clamp is independently associated with glomerular filtration rate in elderly men
Authors: Elisabet Nerpin, U Risérus, E Ingelsson, J Sundström, Magnus Jobs, A Larsson, S Basu, Johan Ärnlöv
Journal: Diabetes Care (2008)

OBJECTIVE—To investigate the association between insulin sensitivity and glomerular filtration rate (GFR) in the community, with prespecified subgroup analyses in normoglycemic individuals wi ...
Mutational analysis of EGFR and KIT in thymic epithelial tumor
Authors: K. Yoh, Y. Nishiwaki, G. Ishii, K. Goto, K. Kubota, H. Ohmatsu, S. Niho, K. Nagai, A. Ochiai, N. Saijo
Journal: Journal of Clinical Oncology (2007)

18049 Background: Thymic epithelial tumor has been reported to express the epidermal growth factor receptor (EGFR), and thymic carcinoma has recently been described to have overexpression of KIT. We investigated the prevalence of EGFR and KIT mutations in patients with thymoma and thymic carcinoma to explore the potential for a targeted therapy with tyrosine kinase inhibitors. Methods: Genomic DNA was isolated from 41 paraffin-embedded tumor samples including 24 thymoma and 17 thymic carcinoma. EGFR mutations in exons 18, 19 and 21, and KIT mutations in exons 9, 11, 13 and 17, were analyzed by PCR and direct sequencing. Protein expressions of EGFR and KIT were also evaluated by immunohistochemistry. Results: We detected the EGFR mutation in 2 of 20 thymoma, but none of thymic carcinoma had mutation. All of the detected EGFR mutations were missense mutations in exon 21 (L858R and G863D, respectively). Expression of EGFR was seen in 71% of thymoma and 53% of thymic carcinoma. On mutational analysis of KIT, only one thymic carcinoma displayed a missense mutation in exon 11 (L576P). Expression of KIT was observed in 88% of thymic carcinoma and 0% of thymoma. Conclusions: Our findings indicate that a small number of patients with thymic epithelial tumor exhibit somatic mutations of EGFR or KIT although expressions of EGFR or KIT are present frequently in thymic epithelial tumor. Further investigations are warranted to determine their susceptibility to tyrosine kinase inhibitors in the treatment of thymoma and thymic carcinoma with EGFR or KIT mutations. No significant financial relationships to disclose.