HYPERSENSITIVITY AND RHEUMATIC FEVER. PART II. RELATION OF RHEUMATIC FEVER TO HYPERSENSITIVITY
Authors: Jerry K. Aikawa
Journal: Annals of Internal Medicine (1945)

Article1 December 1945HYPERSENSITIVITY AND RHEUMATIC FEVER. PART II. RELATION OF RHEUMATIC FEVER TO HYPERSENSITIVITYJERRY K. AIKAWA, M.D.JERRY K. AIKAWA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-23-6-983 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCLINICAL AND PATHOLOGICAL EVIDENCESAs early as 1886 Haig-Brown observed that an incubation period precedes the development of acute rheumatism following a pharyngeal infection. This period is comparable to that which precedes the development of serum sickness following the administration of serum.Derick, Hitchcock and Swift,27in 1928, reported that the administration of acetylsalicylic acid prevents the arthritis of serum sickness, but does not relieve the other symptoms and signs of the disease, as it does in rheumatic fever. The serum of patients treated prophylactically with this drug failed to precipitate horse serum. Untreated patients had a marked rise in...Bibliography1. RATNER B: The evolution of our present knowledge of hypersensitiveness, Bull. New York Acad. Med., 1942, xviii, 527-536. Google Scholar2. RICHET CR: Anaphylaxis, tr. by J. Murray Bligh, 1913, London, Constable. Google Scholar3. VON PIRQUET CE: Allergy, Arch. Int. Med., 1911, vii, 258-288, 383-436. CrossrefGoogle Scholar4. ZINSSER H: Resistance to infectious diseases, ed. 4, 1931, Macmillan, N. Y. CrossrefGoogle Scholar5. HEIDELBERGER M: Contributions of chemistry to the knowledge of immune processes, Medicine, 1933, xii, 279-295. CrossrefGoogle Scholar6. BREINLHAUROWITZ FF: Chemische Untersuchung des Präzipitates aus Hämoglobin und Anti-Hämoglobin-Serum und Bemerkungen über die Natur der Antikörper, Ztschr. f. physiol. Chem., 1930, cxcii, 45-57. CrossrefGoogle Scholar7. 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