tbuckley/cabot-search huggingface dataset:
Characteristics and outcome of patients in whom reperfusion with intravenous tissue-type plasminogen activator fails: results of the Thrombolysis and Angioplasty in Myocardial Infarction (TAMI) I trial.
Authors: R MCaliff, E JTopol, B SGeorge, J MBoswick, K LLee, DStump, JDillon, CAbbottsmith, R JCandela, D JKereiakes
Journal: Circulation (1988)

To examine the outcome of patients with persistent coronary artery occlusion despite treatment with intravenous tissue-type plasminogen activator (t-PA), the clinical course of 96 patients with persistent occlusion after 90 min of therapy was evaluated. All patients underwent cardiac catheterization 90 min after initiation of intravenous t-PA. Immediate coronary angioplasty (PTCA) was attempted when the infarct-related artery failed to reperfuse unless the vessel was technically unsuitable or the infarct was thought to be small. No baseline differences could be found between these 96 patients and 288 patients who achieved perfusion with the same protocol. Although patients with and without successful perfusion after t-PA had similar clinical courses before cardiac catheterization, those without perfusion had more complications (ventricular fibrillation, severe bradycardia, hypotension) during catheterization. PTCA achieved reperfusion with less than 50% residual stenosis in 73% of the 86 patients in whom ...
Characteristics and risk factors for SARS-CoV-2 in children tested in the early phase of the pandemic: a cross-sectional study, Italy, 23 February to 24 May 2020
Authors: Marzia Lazzerini, Idanna Sforzi, Sandra Trapani, Paolo Biban, Davide Silvagni, Giovanna Villa, Jessica Tibaldi, Luca Bertacca, Enrico Felici, Giuseppina Perricone, Roberta Parrino, Claudia Gioè, Sara Lega, Mariasole Conte, Federico Marchetti, Annamaria Magista, Paola Berlese, Stefano Martelossi, Francesca Vaienti, Enrico Valletta, Margherita Mauro, Roberto Dall’Amico, Silvia Fasoli, Antonio Gatto, Antonio Chiaretti, Danica Dragovic, Paola Pascolo, Chiara Pilotto, Ilaria Liguoro, Elisabetta Miorin, Francesca Saretta, Gian Luca Trobia, Antonella Di Stefano, Azzurra Orlandi, Fabio Cardinale, Riccardo Lubrano, Alessia Testa, Marco Binotti, Valentina Moressa, Egidio Barbi, Benedetta Armocida, Ilaria Mariani
Journal: Eurosurveillance (2021)

BackgroundVery few studies describe factors associated with COVID-19 diagnosis in children.AimWe here describe characteristics and risk factors for COVID-19 diagnosis in children tested in 20 paediatric centres across Italy.MethodsWe included cases aged 0-18 years tested between 23 February and 24 May 2020. Our primary analysis focused on children tested because of symptoms/signs suggestive of COVID-19.ResultsAmong 2,494 children tested, 2,148 (86.1%) had symptoms suggestive of COVID-19. Clinical presentation of confirmed COVID-19 cases included besides fever (82.4%) and respiratory signs or symptoms (60.4%) also gastrointestinal (18.2%), neurological (18.9%), cutaneous (3.8%) and other unspecific influenza-like presentations (17.8%). In multivariate analysis, factors significantly associated with SARS-CoV-2 positivity were: exposure history (adjusted odds ratio (AOR): 39.83; 95% confidence interval (CI): 17.52-90.55; p < 0.0001), cardiac disease (AOR: 3.10; 95% CI: 1.19-5.02; p < 0.0001), fever (AOR: 3.05%; 95% CI: 1.67-5.58; p = 0.0003) and anosmia/ageusia (AOR: 4.08; 95% CI: 1.69-9.84; p = 0.002). Among 190 (7.6%) children positive for SARS-CoV-2, only four (2.1%) required respiratory support and two (1.1%) were admitted to intensive care; all recovered.ConclusionRecommendations for SARS-CoV-2 testing in children should consider the evidence of broader clinical features. Exposure history, fever and anosmia/ageusia are strong risk factors in children for positive SARS-CoV-2 testing, while other symptoms did not help discriminate positive from negative individuals. This study confirms that COVID-19 was a mild disease in the general paediatric population in Italy. Further studies are needed to understand risk, clinical spectrum and outcomes of COVID-19 in children with pre-existing conditions.
Wegener's Granulomatosis
Authors: I ERLING
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Difficult Biliary Stones in the Elderly: Endoscopic Retrograde Cholangiography. A Single Surgical Tertiary Center Experience With Follow Up
Authors: P Antypas, F Cereatti, F Fiocca, A Cappello, C Eberspacher, G Fanello, D Mascagni, G Donatelli
Journal: Endoscopy (2021)

Aims Pancreaticobiliary diseases and choledocholithiasis are common in elderly patients. Endoscopic treatment of biliary stones represents a well-established mini-invasive technique. However, limited data are available regarding the treatment of “difficult” biliary stones in elderly population. The aim of our study is to evaluate the efficacy and safety of therapeutic endoscopic retrograde cholangiopancreatography (ERCP) in patients ≥85 years of age with complex biliary stones.
Vascular remodeling and improvement of coronary reserve after hydralazine treatment in spontaneously hypertensive rats.
Authors: P GAnderson, S PBishop, S BDigerness
Journal: Circulation Research (1989)

The purpose of these studies was to evaluate cardiovascular structural and functional changes in a model of hypertension-induced myocardial hypertrophy in which vasodilator therapy decreased blood pressure to normal levels. Thus, we determined the separate contributions of hypertension and hypertrophy on myocardial and coronary vascular function and structure. Twelve-month-old spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY) with and without 12 weeks of vasodilator antihypertensive treatment (hydralazine) were studied using an isolated perfused rat heart model. Hydralazine treatment normalized blood pressure in SHR but did not cause regression of cardiac hypertrophy (heart weight to body weight ratio of SHR + hydralazine 4.33 +/- 0.098 vs. SHR 4.66 +/- 0.091; WKY 3.21 +/- 0.092 and WKY + hydralazine 3.38 +/- 0.152; mean +/- SEM). Coronary flow reserve, elicited by adenosine vasodilation in the perfused heart, was decreased in SHR (29%) compared with WKY (105%) and WKY + hydra...
Sulfonylureas, ATP-sensitive K+ channels, and cellular K+ loss during hypoxia, ischemia, and metabolic inhibition in mammalian ventricle.
Authors: NVenkatesh, S TLamp, J NWeiss
Journal: Circulation Research (1991)

Sulfonylurea derivatives glibenclamide and tolbutamide are selective blockers of ATP-sensitive K+ (KATP) channels. However, their ability to prevent cellular K+ loss and shortening of action potential duration during ischemia or hypoxia in the intact heart is modest compared with their efficacy at blocking KATP channels in excised membrane patches. In the isolated arterially perfused rabbit interventricular septum, the increase in unidirectional K+ efflux and shortening of action potential duration during substrate-free hypoxia were effectively blocked by glibenclamide, but only by very high concentrations (100 microM); during hypoxia with glucose present, glibenclamide was only partially effective at reducing K+ loss. During total global ischemia (10 minutes), up to 100 microM glibenclamide or 1 mM tolbutamide attenuated shortening of action potential duration but only reduced [K+]0 accumulation by a maximum of 32 +/- 6%. In isolated patch-clamped guinea pig ventricular myocytes in which the whole-cell A...
Expected gains in life expectancy from various coronary heart disease risk factor modifications.
Authors: JTsevat, M CWeinstein, L WWilliams, A NTosteson, LGoldman
Journal: Circulation (1991)

BACKGROUNDDespite much evidence that modifying risk factors for coronary heart disease can decrease morbidity and mortality, little is known about the impact of risk-factor modification on life expectancy.METHODS AND RESULTSWe used the Coronary Heart Disease Policy Model, a state-transition computer simulation of the US population, to forecast potential gains in life expectancy from risk-factor modification for the cohort of Americans turning age 35 in 1990. Among 35-year-old men, we projected that the population-wide increase in life expectancy would be about 1.1 years from strict blood pressure control, 0.8 years from smoking cessation, 0.7 years from reduction of serum cholesterol to 200 mg/dl, and about 0.6 years from weight loss to ideal body weight. For women, reducing cholesterol to 200 mg/dl would have the greatest estimated impact-a gain of 0.8 years-whereas smoking cessation, blood pressure control, or weight loss would yield population-wide gains of 0.7, 0.4, and 0.4 years, respectively. Gains ...
The effect of streptozotocin-induced diabetes in rats on cardiac contractile proteins.
Authors: AMalhotra, SPenpargkul, F SFein, E HSonnenblick, JScheuer
Journal: Circulation Research (1981)

In order to determine whether diabetic cardiomyopathy in rats is associated with altered contractile proteins, male and female rats were made diabetic with intravenous streptozotocin (STZ). Calcium ATPase activity of cardiac actomyosin was significantly decreased after 1 week of diabetes and was depressed by 60% by 2 weeks. Rats pretreated with 3-O-methyl glucose to prevent the hyperglycemia caused by STZ had normal Ca2+-actomyosin ATPase activities, and non-diabetic rats whose food was restricted to keep their body and heart weights similar to those found in diabetic animals had only a slight fall in actomyosin ATPase activity. Ca2+-ATPase and actin-activated ATPase activities of pure myosin were similarly depressed in preparations from hearts of diabetic animals. Sodium dodecylsulfate gel electrophoresis and isoelectric focusing failed to reveal differences in the patterns of contractile proteins or light subunits between diabetics and controls, but pyrophosphate gels showed a shift in the myosin patter...
Lymph and pulmonary response to isobaric reduction in plasma oncotic pressure in baboons.
Authors: C KZarins, C LRice, R MPeters, R WVirgilio
Journal: Circulation Research (1978)

Plasma colloid osmotic pressure was reduced by 76% (from 19.6 +/- 0.6 to 4.7 +/- 1.5 mm Hg) in five baboons while pulmonary capillary hydrostatic pressure was maintained at a normal level. This resulted in fluid retention, weight gain, peripheral edema and ascites, but no pulmonary edema. Thoracic duct lymph flow increased 6-fold and pulmonary lymph flow 7-fold. Thoracic duct lymph had a lower colloid osmotic pressure (2.0 +/- 0.7 mm Hg) than plasma (4.7 +/- 1.5 mm Hg), whereas the colloid osmotic pressure of pulmonary lymph (4.7 +/- 0.7 mm Hg) was the same as that of plasma. The lymph-plasma ratio for albumin fell in thoracic duct lymph but remained unchanged in pulmonary lymph. The difference between plasma colloid osmotic pressure and pulmonary artery wedge pressure decreased from 15.3 +/- 1.9 to -0.7 +/- 2.9 mm Hg. Despite this increase in filtration force, the lungs were protected from edema formation by a decrease of 11 mm Hg in pulmonary interstitial colloid osmotic pressure and a 7-fold increase i...
The University of Alabama at Birmingham (UAB) Raptor method for direct percutaneous endoscopic gastrostomy with jejunal extension tube placement
Authors: Alvaro Martínez-Alcalá, Klaus Mönkemüller
Journal: Endoscopy (2021)

Direct percutaneous endoscopic gastrostomy with a jejunal extension tube (PEG-J) is a useful method of providing nutrition to patients with a variety of gastrointestinal (GI) problems [1] [2]. However, placing a PEG-J is difficult, especially when delivering the jejunal extension tube into the jejunum [1] [2]. Often the J-tube bounces back into the stomach during or shortly after having positioned it endoscopically [1] [2] [3]. Indeed, some experts have developed techniques with balloon enteroscopes to block the pylorus and prevent the tube from bouncing back into the stomach [3]. The present report describes a novel and simple method of direct percutaneous endoscopic gastrostomy with PEG-J placement using an extra-long foreign body forceps.
Abstract 13378: SDPR/Cavin-2 in Endothelial Cells Contributes to Inflammatory Cell Adhesion in Abdominal Aortic Aneurysm
Authors: Akira Sakamoto, Takehiro Ogata, Naohiko Nakanishi, Yusuke Higuchi, Yumika Tsuji, Shinya Tomita, Satoaki Matoba
Journal: Circulation (2019)

Introduction: Abdominal aortic aneurysm (AAA) is a common and life-threatening vascular disease. Vascular inflammation is the initial phase of aneurysm progression. Adhesion molecules, such as vasc...
Preservation of glomerular filtration rate in human heart failure by activation of the renin-angiotensin system.
Authors: MPacker, W HLee, P DKessler
Journal: Circulation (1986)

When renal perfusion pressure is reduced in experimentally induced low-output states, glomerular filtration rate is preserved by angiotensin II-mediated efferent arteriolar vasoconstriction, but available evidence in man suggests that angiotensin II supports renal function only to the extent that it preserves systemic blood pressure. We performed simultaneous assessments of cardiac and renal function in 56 patients with severe chronic heart failure before and after 1 to 3 months of converting-enzyme inhibition. Among the 29 patients with a pretreatment renal perfusion pressure under 70 mm Hg, patients with preserved renal function (creatinine clearance greater than 50 ml/min/1.73 m2) had markedly elevated values for plasma renin activity (11.8 +/- 3.8 ng/ml/hr) and showed a significant decline in creatinine clearance after converting-enzyme inhibition (61.1 +/- 3.0 to 45.9 +/- 5.3 ml/min/1.73 m2; p less than .05). In contrast, although similar with respect to all pretreatment demographic, hemodynamic, and...
Characteristics of transient outward current in human ventricular myocytes from patients with terminal heart failure.
Authors: MNäbauer, D JBeuckelmann, EErdmann
Journal: Circulation Research (1993)

A variety of outward currents exists in ventricular myocardium of different species influencing action potential duration and electrical activity. Transient outward currents have been reported in ventricular tissue of some animals but are small or absent in others. This study was conducted to investigate whether a transient outward current exists in human ventricular myocardium and to characterize its basic electrophysiological properties. Currents were recorded from enzymatically isolated human ventricular myocytes obtained from explanted hearts of 22 patients with terminal heart failure. In almost all cells studied, a transient outward current could be recorded on depolarization to between -20 and +80 mV. The size of the transient outward current was usually large enough to mask the Ca2+ current. It could be recorded under conditions in which Ca2+ influx and intracellular Ca2+ transients were suppressed. Basic current characteristics were similar to transient outward currents observed in other species. ...
133P Drug-drug interactions (DDIs) in non-small cell lung cancer during chemotherapy-immunotherapy treatment
Authors: M. Occhipinti, M. Brambilla, G. Galli, S. Manglaviti, A. Prelaj, R. Ferrara, A. De Toma, T. Beninato, E. Zattarin, C. Proto, G. Lo Russo, A.J. Gelibter, M. Simmaco, M.C. Garassino, P. Marchetti
Journal: Journal of Thoracic Oncology (2021)
Renal responses of the cardiac-denervated nonhuman primate to blood volume expansion.
Authors: T VPeterson, C EJones
Journal: Circulation Research (1983)

Experiments were performed to determine whether total, specific cardiac denervation affects the renal responses of the nonhuman primate to acute intravascular volume expansion. Adult male Macaca fascicularis monkeys underwent chronic intrapericardial cardiac denervation or sham surgery. After a 14- to 30-day recovery period, each animal was anesthetized with sodium pentobarbital and estimated blood volume was volume-expanded 20% with 6% dextran in isotonic saline. Control renal excretory function did not differ between the two groups, and both groups had similar increases in urine flow, sodium and potassium excretion, osmolar clearance, free water clearance, and renal plasma flow after volume expansion. The times to peak diuresis and natriuresis also were similar in both groups. These results demonstrate that the cardiac-denervated monkey shows unattenuated renal excretory responses to volume expansion. This could indicate that either cardiac receptors do not play a major role in eliciting these responses...
An oscillatory current in sheep cardiac Purkinje fibers.
Authors: MVassalle, AMugelli
Journal: Circulation Research (1981)

The inward current (oscillatory current) which may be present after the end of a depolarizing clamp was studied in sheep cardiac Purkinje fibers by means of a voltage-clamp method. The following results were obtained. In order to appear, the oscillatory current (Ios) requires a previous depolarization to approximately or equal to -20 mV or beyond and a repolarization to approximately or equal to -40 mV or to more negative potentials. The Ios requires a minimum duration of the depolarizing clamp and becomes larger with longer clamps. With repolarization to more negative potentials (approximately or equal to 90 mV), Ios becomes smaller and may disappear. Also Ios can be triggered twice if the potential is clamped to two different levels in succession. By several procedures which modify the other known currents (fast Na+ current, slow inward current, early outward current, plateau current Ix1 and pacemaker current), it can be demonstrated that Ios is not due to their oscillatory behavior and can occur in t...
Randomized phase II study of three doses of the integrin inhibitor cilengitide versus docetaxel as second-line treatment for patients (pts) with stage IV non-small cell lung cancer (NSCLC)
Authors: C. Manegold, J. Vansteenkiste, F. Cardenal, W. Schütte, P. Woll, E. Ulsperger, B. Rüter, M. Picard, J. Eckmayr, J. von Pawel
Journal: Journal of Clinical Oncology (2009)

8014 Background: Cilengitide (EMD 121974) is the most advanced compound in clinical development of a new class of oncology drugs, the integrin inhibitors. Integrins (heterodimeric transmembrane receptors) play key roles in cell interactions. Cilengitide selectively inhibits the cell-surface integrins α V β 3 and α V β 5 on activated endothelial cells during angiogenesis and on tumor cells. Methods: Multicenter, open-label, randomized, phase II study in 140 pts with relapsed stage IV NSCLC. Pts received 1 of 3 cilengitide doses (240 [n=35], 400 [n=35], or 600 [n=36] mg/m 2 ) twice weekly or docetaxel 75 mg/m 2 (n=34) once every 3-week cycle for 6 months. Responding pts could continue cilengitide for up to 1 year. Primary endpoint: progression-free survival (PFS). Results: Median age (range) was 60 (33–80) years; 94 pts were male (67%); 83% of pts had KPS ≥80%. Median PFS (95% CI) was 54 (43–64), 63 (53–66), 63 (42–67), and 67 (61–123) days for cilengitide 240, 400, 600, and docetaxel 75 mg/m 2 , respectively. Median OS (95% CI) was 173 (81–197), 117 (92–209), 181 (90–326), and 194 (135–298) days, respectively. One-year survival rate (95% CI) was 13% (1–24%), 13% (0–26%), 29% (12–37%), and 27% (10–43%), respectively. Survival was similar with cilengitide 600 mg/m 2 and docetaxel 75 mg/m 2 : median OS 181 versus 194 days and 1-year survival rate (95% CI) 29% (12–37%) versus 27% (10–43%). Five docetaxel pts (15%) had a partial response. Most pts (98%) had ≥1 adverse event (AE). Most common AEs were dyspnea (33%), nausea (30%), tumor progression (29%), and cough (23%). Dyspnea and tumor progression were more common with cilengitide than with docetaxel. Grade 3/4 treatment-related AEs were more common with docetaxel (n=13, 41%) than cilengitide 240 (n=2, 6%), 400 (n=4, 11%), or 600 (n=4, 11%) mg/m 2 . For cilengitide, these were nausea, chest pain, dyspnea, and fatigue. Conclusions: PFS in the docetaxel group was greater than that of cilengitide at all doses. However, cilengitide monotherapy at a dose of 600 mg/m 2 showed similar OS to docetaxel and better tolerability. Combination studies with standard chemotherapy and cilengitide are warranted. [Table: see text]
Alterations in electrical activity and membrane currents induced by intracellular oxygen-derived free radical stress in guinea pig ventricular myocytes.
Authors: R IJabr, W CCole
Journal: Circulation Research (1993)

Oxygen-derived free radicals (O-Rs) are thought to induce alterations in cardiac electrical activity; however, the underlying membrane ionic currents affected by O-Rs and the mechanisms by which O-Rs induce their effects on ion channels in the heart are not well defined. In this study, we investigated the time-dependent changes in resting membrane potential and action potential configuration and changes in steady-state membrane currents in guinea pig ventricular myocytes after intracellular application of an O-R-generating system. O-Rs were generated from the combination of dihydroxyfumaric acid (3 mM) and FeCl3:ADP (0.05:0.5 mM) added to the pipette solution that was used to record membrane potential and currents via the whole-cell variant of the patch-clamp technique. Intracellular exposure of myocytes to the O-R-generating solution induced three stages of changes: 1) an early depolarization (5-10 mV) and an increase in action potential duration accompanied by a decrease in resting inward rectifying K+ ...