tbuckley/cabot-search huggingface dataset:
Mendelian randomization of genetically independent aging phenotypes identifies LPA and VCAM1 as biological targets for human aging
Authors: Paul R. H. J. Timmers, Evgeny S. Tiys, Saori Sakaue, Masato Akiyama, Tuomo T. J. Kiiskinen, Wei Zhou, Shih-Jen Hwang, Chen Yao, Yoichiro Kamatani, Wei Zhou, Joris Deelen, Daniel Levy, Andrea Ganna, Yoichiro Kamatani, Yukinori Okada, Peter K. Joshi, James F. Wilson, Yakov A. Tsepilov
Journal: Nature Aging (2022)

Length and quality of life are important to us all, yet identification of promising drug targets for human aging using genetics has had limited success. In the present study, we combine six European-ancestry genome-wide association studies of human aging traits—healthspan, father and mother lifespan, exceptional longevity, frailty index and self-rated health—in a principal component framework that maximizes their shared genetic architecture. The first principal component (aging-GIP1) captures both length of life and indices of mental and physical wellbeing. We identify 27 genomic regions associated with aging-GIP1, and provide additional, independent evidence for an effect on human aging for loci near HTT and MAML3 using a study of Finnish and Japanese survival. Using proteome-wide, two-sample, Mendelian randomization and colocalization, we provide robust evidence for a detrimental effect of blood levels of apolipoprotein(a) and vascular cell adhesion molecule 1 on aging-GIP1. Together, our results demonstrate that combining multiple aging traits using genetic principal components enhances the power to detect biological targets for human aging. Many aging-related phenotypes share a common genetic component, but to disentangle disease-specific variants from aging-specific ones has been challenging. Here Timmers et al. combined several genetics studies of aging-related traits to identify common underlying genetic factors that contribute to aging.
Sydenham's Chorea
Authors: Susan E. Swedo
Journal: JAMA (1994)

<h3>SELECTED CASE</h3> Faith (not her real name), a 9-year-old girl, presented to the local hospital's emergency department with a chief complaint of "St Vitus' dance." Her grandfather had noticed her clumsy gait and frequent jerky movements and had concluded that "she must have St Vitus' dance, just like her Aunt Cecilia did when she was 7." In retrospect, Faith had at least a 2-week history of increasing fidgetiness, clumsiness, and subtle choreiform movements. During the week prior to presentation, she had noticed a deterioration in her handwriting skills and had been having increasing difficulties with speaking, walking, and such daily activities as brushing her teeth, manipulating a fork, and drinking from a glass. About a month prior to presentation, Faith had experienced the abrupt onset of nightmares and of anxiety about being separated from her mother. At about the same time, she began to wash her hands excessively (up to
A Student's Manual of Surgical Diagnosis.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Епідеміологічні й терапевтичні аспекти хронічних дифузних захворювань печінки у військовослужбовців
Authors: G.V. Osyodlo
Journal: GASTROENTEROLOGY (2013)

У статті проаналізовано результати статистичної звітності щодо захворюваності, структури та підходів до лікування хронічних дифузних захворювань печінки (ХДЗП) у військовослужбовців. Показано, що ХДЗП займають друге рангове місце у структурі хвороб органів травлення серед офіцерів та військовослужбовців контрактної служби, третє місце — серед військовослужбовців строкової служби, і впродовж 10-річного статистичного ряду рівень захворюваності на ХДЗП збільшився в 1,2 раза. У структурі ХДЗП серед офіцерів і військовослужбовців контрактної служби переважає хронічний гепатит невірусної етіології, а серед військовослужбовців строкової служби — хронічний вірусний гепатит. Для лікування ХДЗП як вірусної (у 76,9 % хворих), так і невірусної етіології (у 67,3 % хворих) використовували есенціальні фосфоліпіди, урсодезоксихолеву кислоту та їх поєднання.
Distinguished visitor from Isreal
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Säuglings-Ernährungs-Tafel.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Patient-Reported Outcome-Based Symptom Management Versus Usual Care After Lung Cancer Surgery: A Multicenter Randomized Controlled Trial
Authors: Wei Dai, Wenhong Feng, Yuanqiang Zhang, Xin Shelley Wang, Yangjun Liu, Cecilia Pompili, Wei Xu, Shaohua Xie, Yaqin Wang, Jia Liao, Xing Wei, Run Xiang, Bin Hu, Bo Tian, Xiaozun Yang, Xiang Wang, Ping Xiao, Qi Lai, Xin Wang, Bangrong Cao, Qifeng Wang, Fang Liu, Xiaoqin Liu, Tianpeng Xie, Xiaojun Yang, Xiang Zhuang, Zhong Wu, Guowei Che, Qiang Li, Qiuling Shi
Journal: Journal of Clinical Oncology (2022)

We aimed to evaluate the efficacy and feasibility of patient-reported outcome (PRO)-based symptom management in the early period after lung cancer surgery.Before surgery, patients with clinically diagnosed lung cancer were randomly assigned 1:1 to receive postoperative PRO-based symptom management or usual care. All patients reported symptoms on MD Anderson Symptom Inventory-Lung Cancer presurgery, daily postsurgery, and twice a week after discharge for up to 4 weeks via an electronic PRO system. In the intervention group, treating surgeons responded to overthreshold electronic alerts driven by any of the five target symptom scores (score ≥ 4 on a 0-10 scale for pain, fatigue, disturbed sleep, shortness of breath, and coughing). The control group patients received usual care and no alerts were generated. The primary outcome was the number of symptom threshold events (any target symptom with a score of ≥ 4) at discharge. Per-protocol analyses were conducted.Of the 166 participants, 83 were randomly allocated to each group. At discharge, the intervention group reported fewer symptom threshold events than the control group (median [interquartile range], 0 [0-2] v 2 [0-3]; P = .007). At 4 weeks postdischarge, this difference was maintained between the intervention and control groups (median [interquartile range], 0 [0-0] v 0 [0-1]; P = .018). The intervention group had a lower complication rate than the control group (21.5% v 40.6%; P = .019). Surgeons spent a median of 3 minutes managing an alert.PRO-based symptom management after lung cancer surgery showed lower symptom burden and fewer complications than usual care for up to 4 weeks postdischarge.
Hypercholesterolemia is undertreated in patients with coronary artery disease. Results of a survey in 1997 and a survey in 2000 Frank Vermeer, Patrick Limpt, Janneke Harting, Jurn van der Wild, Anton Gorgels, Aimee Lousberg, Margaret Tychon, Eric Ruland, Jan van Ree. University Hospital Maastricht, Maastricht, The Netherlands, University Maastricht, Maastricht, The Netherlands
Journal: Journal of the American College of Cardiology (2001)
Psychiatry: A World Perspective, vol. 1: Classification and Psychopathology; Child Psychiatry; Substance Use. Proceedings of the VIII World Congress of Psychiatry, Athens, 12-19 October 1989; Psychiatry: A World Perspective, vol. 2: Neuroscience in Psychiatry; Biological Correlates of Mental Disorders. Proceedings of the VIII World Congress of Psychiatry, Athens, 12-19 October 1989; Psychiatry: A World Perspective, vol. 3: Pharmacotherapies; Psychotherapies; Other Therapies. Proceedings of the …
Authors: MARK-ANDRÉ ROY
Journal: American Journal of Psychiatry (1993)
FromJAMA’s Daily News Site
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Exploratory analysis of baseline tumor burden in the TRUSTY study: A randomized phase 2/3 study of trifluridine/tipiracil plus bevacizumab versus irinotecan and fluoropyrimidine plus bevacizumab as second-line treatment in patients with metastatic colorectal cancer.
Authors: Toshiki Masuishi, Yasutoshi Kuboki, Tetsuji Terazawa, Masato Nakamura, Jun Watanabe, Hitoshi Ojima, Akitaka Makiyama, Masahito Kotaka, Hiroki Hara, Takashi Ohta, Eiji Oki, Yu Sunakawa, Soichiro Ishihara, Hiroya Taniguchi, Takako Eguchi Nakajima, Satoshi Morita, Kuniaki Shirao, Takayuki Yoshino
Journal: Journal of Clinical Oncology (2022)

87 Background: In primary analysis from the TRUSTY study, trifluridine/tipiracil (FTD/TPI) plus bevacizumab (BEV) failed to show non-inferiority to irinotecan and fluoropyrimidine plus BEV in overall survival (OS) as second-line treatment in patients (pts) with metastatic colorectal cancer (mCRC) (median OS, 14.8 vs. 18.1 months: HR, 1.38: 95% CI; 0.99-1.93: p = 0.59 for non-inferiority; Kuboki Y, et al. ASCO 2021). Here we report a post hoc efficacy analysis by baseline tumor burden. Methods: Pts with histologically confirmed mCRC who failed first-line chemotherapy with fluoropyrimidine and oxaliplatin plus either BEV or an anti-EGFR antibody were eligible. Pts were randomized to receive either FTD/TPI plus BEV (FTD/TPI plus BEV group, FTD/TPI 35 mg/m 2 twice daily on days 1–5 and 8–12 every 28-day cycle, and BEV 5 mg/kg on days 1 and 15) or either FOLFIRI or S-1 and irinotecan combined with BEV (control group). Efficacy measured by OS, progression-free survival (PFS), and disease control rate (DCR) were compared between pts grouped by baseline sum of diameter of target lesions (STL). Survival curves were drawn by direct survival estimation adjusted for stratification factors. Results: In the ITT population (N = 396), 60 mm was selected as the optimal cutoff for STL because it produced the most significant difference in OS; 151 pts had high tumor burden with STL ≥ 60 mm (FTD/TPI plus BEV, n = 76: control, n = 75), 216 had low tumor burden with STL &lt; 60 mm (n = 107, n = 109), and 29 were excluded due to no measurable lesions. Baseline characteristics in pts with both high and low tumor burden were balanced between treatment groups. In pts with STL ≥ 60 mm, FTD/TPI plus BEV was less effective than the control: adjusted median OS was 10.9 versus 16.2 months (HR: 2.32; 95% CI: 1.42-3.79), median PFS was 3.5 versus 6.1 months (HR: 2.32; 95% CI: 1.52-3.53): and DCR was 53.9% versus 72.0% (p = 0.03). In pts with STL &lt; 60 mm, FTD/TPI plus BEV was comparably effective to the control: median OS was 21.4 versus 20.7 months (HR: 0.92; 95% CI: 0.55-1.55), median PFS was 5.6 versus 6.0 months (HR: 1.23; 95% CI: 0.87-1.72), and DCR was 66.4% versus 71.6% (p = 0.46). Conclusions: FTD/TPI + BEV might be a second-line treatment option for mCRC pts with low tumor burden (STL &lt; 60 mm). Clinical trial information: jRCTs031180122.
Association Between Assistance With Medicaid Enrollment and Use of Health Care After Incarceration Among Adults With a History of Substance Use
Authors: Marguerite E. Burns, Steven Cook, Lars M. Brown, Laura Dague, Steve Tyska, Karla Hernandez Romero, Cici McNamara, Ryan P. Westergaard
Journal: JAMA Network Open (2022)

The transition from prison to community is characterized by elevated morbidity and mortality, particularly owing to drug overdose. However, most formerly incarcerated adults with substance use disorders do not use any health care, including treatment for substance use disorders, during the initial months after incarceration.To evaluate whether a prerelease Medicaid enrollment assistance program is associated with increased health care use within 30 days after release from prison.This retrospective cohort study included 16 307 adults aged 19 to 64 years with a history of substance use who were released from state prison between April 1, 2014, and December 31, 2016. The Wisconsin Department of Corrections implemented prerelease Medicaid enrollment assistance in January 2015. Statistical analysis was performed from January 1 to August 31, 2021.A statewide Medicaid prerelease enrollment assistance program.The main outcome was Medicaid-reimbursed health care, associated with substance use disorders and for any cause, within 30 days of prison release, including outpatient, emergency department, and inpatient care. Mean outcomes were compared for those released before and after implementation of prerelease Medicaid enrollment assistance using an intention-to-treat analysis and person-level data from the Wisconsin Department of Corrections and Medicaid.The sample included 16 307 individuals with 18 265 eligible releases (men accounted for 16 320 of 18 265 total releases, and 6213 of 18 265 releases were among Black individuals; mean [SD] age at release, 35.5 [10.7] years). The likelihood of outpatient care use within 30 days of release increased after implementation of enrollment assistance relative to baseline by 7.7 percentage points for any visit (95% CI, 6.4-8.9 percentage points; P < .001), by 0.7 percentage points for an opioid use disorder visit (95% CI, 0.4-1.0 percentage points; P < .001), by 1.0 percentage point for any substance use disorder visit (95% CI, 0.5-1.6 percentage points; P < .001), and by 0.4 percentage points for receipt of medication for opioid use disorder (95% CI, 0.2-0.6 percentage points; P < .001). There was no significant change in use of the emergency department (0.7 percentage points [95% CI, -0.15 to 1.4 percentage points]). The probability of an inpatient stay increased by 0.4 percentage points (95% CI, 0.03-0.7 percentage points; P = .03).The results of this cohort study suggest that prerelease Medicaid enrollment assistance was associated with increased use of outpatient health care after incarceration and highlights the value of making this assistance universally available within correctional settings. More tailored interventions may be needed to increase the receipt of treatment for substance use disorders.
The British Society of Gastroenterology. Annual meeting 28 to 30 September 1983, York. Abstracts.
Authors: C Swain, S Brown
Journal: Gut (1983)

1983 at the University of York under the presidency of Professor J E Lennard-Jones.One hundred and twelve communications (including 43 posters) were selected for presentation in the scientific programme; the abstracts are printed belpw.Further details of the meeting appear on p. 966.ENDOSCOPY TI-5 TI Pancreatic orifice sphincterotomy; experience from 15 centres P B COITON (Department of Gastro- enterology, The Middlesex
Book Listings
Journal: Annals of Internal Medicine (2001)

Book Listings6 November 2001Book ListingsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-9-200111060-00001 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail CardiologyCardioFaxDA Tighe, JR Cook, MJ Schweiger, and EK Chung. 239 pages. Cambridge, MA: Blackwell Science; 2001. $30.00. ISBN 0865425639. Order phone 800-759-6102.Coronary Artery Stenting: A Case-Oriented ApproachN Curzen and MT Rothman, eds. 194 pages. Philadelphia: Taylor & Francis; 2001. $120.00. ISBN 1853177180. Order phone 800-821-8312.Evidence-Based Manual of Coronary Care ManagementM Connaughton. 195 pages. Philadelphia: WB Saunders; 2001. $35.00. ISBN 0443064156. Order phone 215-238-7800.Fundamental Approaches to the Management of Cardiac ArrhythmiasRJ Sung and MR Lauer. 804 pages. Boston: Kluwer; 2000. $350.00. ISBN 0792365593. Order phone 781-871-1660.Heart Disease: Review and Assessment4th edition. LS Lilly. 268 pages. Philadelphia: ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 6 November 2001Volume 135, Issue 9Page: B1KeywordsBehaviorCellsPrevention, policy, and public health ePublished: 6 November 2001 Issue Published: 6 November 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Antiapoptotic effects of carvedilol are not mediated by its beta-adrenergic receptor blocking properties Ernst R. Schwarz, Philipp H. Kersting, Dennis Meven, Thorsten Reffelmann, Erik C. Skobel, Peter Hanrath. Med. Clinic I, RWTH University Hospital, Aachen, Germany, Dept. of Cardiology, Dr. S. Fakeeh Hospital (Harvard Medical International), Jeddah, Saudi Arabia
Journal: Journal of the American College of Cardiology (2001)
LONDON LETTER.
Authors: None G. O. M.
Journal: JAMA (1884)

London, October, 1884. The results of the conference of the Red Cross Associations held at Geneva have, according to Surgeon-General Longmore, given satisfaction to the members who attended it. Amongst the matters discussed was the employment of the electric light for searching for the dead and wounded on the battle field. Baron Mundy, basing his remarks upon the experiments made at Wichen in October, 1883, and at Aldershot in July last, as well as those undertaken near Geneva during the conference—which have confirmed the practicability of clearing the field of the wounded during the night following a great battle, and burying the dead after establishing their identity, expressed the hope that in future wars the electric light would be employed in all cases in which military commanders permitted its use. The questions "Shall the Associations acquire during peace the articles and apparatus required in war," and " Is it necessary that
HORIZON (OP-106): Melflufen Plus Dexamethasone (dex) in 55 Patients (pts) with Relapsed/Refractory Multiple Myeloma (RRMM) with Extramedullary Disease (EMD)-Subgroup Analysis
Authors: Paul G. Richardson, María-Victoria Mateos, Albert Oriol, Alessandra Larocca, Michele Cavo, Paula Rodríguez-Otero, Xavier Leleu, Maxim Norkin, Omar Nadeem, John W. Hiemenz, Hani Hassoun, Cyrille Touzeau, Adrián Alegre Amor, Agne Paner, Christopher Maisel, Amitabha Mazumder, Anastasios Raptis, Noemí Puig, Elena Zamagni, Marcus Thuresson, Johan Harmenberg, Olof Harlin, Joan Blade Creixenti
Journal: Blood (2020)
New England Journal of Medicine, Boston
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incremental prognostic value of clinical, exercise treadmill, and scintigraphic data in the elderly Richard M. Steingart, Patty Hodnett, Joseph Musso, Florence M. Prigent, Martin Feuerman. Winthrop-University Hospital, Mineola, NY, Health Sciences Center, SUNY at StonyBrook, StonyBrook, NY
Journal: Journal of the American College of Cardiology (2001)