tbuckley/cabot-search huggingface dataset:
Changes in diastolic function during development and correction of chronic LV volume overload produced by mitral regurgitation.
Authors: M RZile, MTomita, KIshihara, KNakano, JLindroth, FSpinale, MSwindle, B ACarabello
Journal: Circulation (1993)

BACKGROUNDMitral regurgitation (MR) causes an augmentation in left ventricular (LV) diastolic function, increasing early diastolic filling rate and decreasing LV stiffness. Whether these changes in diastolic function persist, return to normal, or become abnormal after mitral valve replacement (MVR) is unknown.METHODS AND RESULTSSimultaneous LV echocardiography and catheterization studies were performed in six dogs in the baseline state (baseline), 3 months after creation of MR (chronic MR), and 3 months after MVR. Chronic MR caused LV dilation (end-diastolic dimension increased from 4.5 +/- 0.1 cm in baseline to 5.8 +/- 0.1 cm in chronic MR, p < 0.05) and eccentric LV hypertrophy (LV-to-body weight ratio increased from 3.6 +/- 0.2 g/kg in baseline to 4.9 +/- 0.4 g/kg in chronic MR, p < 0.05). Chronic MR caused an increase in LV early diastolic filling rate (peak rate of increase in minor-axis dimension increased from 11 +/- 1 cm/sec in baseline to 18 +/- 1 cm/sec in chronic MR, p < 0.05), did not change t...
Real-World Data on Clinical Outcomes of Patients with Liver Cancer: A Prospective Validation of the National Cancer Centre Singapore Consensus Guidelines for the Management of Hepatocellular Carcinoma
Authors: Xin Hui Chew, Rehena Sultana, Eshani N. Mathew, David Chee Eng Ng, Richard H.G. Lo, Han Chong Toh, David Tai, Su Pin Choo, Brian Kim Poh Goh, Sean Xuexian Yan, Kelvin Siu Hoong Loke, Sue Ping Thang, Apoorva Gogna, Nanda Karaddi Venkatanarasimha, Aaron K.T. Tong, Fiona N.N. Moe, Jacelyn S.S. Chua, Reiko W.T. Ang, Aldwin D. Ong, Ashley W.Y. Ng, Marjorie T.Q. Hoang, Chow Wei Too, Choon Hua Thng, Wan Ying Chan, Wanyi Kee, Jaclyn H. M. Chan, Farah Irani, Sum Leong, Kiat Hon Lim, Michael L.C. Wang, Pierce K.H. Chow
Journal: Liver Cancer (2021)

Real-world management of patients with hepatocellular carcinoma (HCC) is crucially challenging in the current rapidly evolving clinical environment which includes the need for respecting patient preferences and autonomy. In this context, regional/national treatment guidelines nuanced to local demographics have increasing importance in guiding disease management. We report here real-world data on clinical outcomes in HCC from a validation of the Consensus Guidelines for HCC at the National Cancer Centre Singapore (NCCS).We evaluated the NCCS guidelines using prospectively collected real-world data, comparing the efficacy of treatment received using overall survival (OS) and progression-free survival (PFS). Treatment outcomes were also independently evaluated against 2 external sets of guidelines, the Barcelona Clinic Liver Cancer (BCLC) and Hong Kong Liver Cancer (HKLC).Overall treatment compliance to the NCCS guidelines was 79.2%. Superior median OS was observed in patients receiving treatment compliant with NCCS guidelines for early (nonestimable vs. 23.5 months p < 0.0001), locally advanced (28.1 vs. 22.2 months p = 0.0216) and locally advanced with macrovascular invasion (10.3 vs. 3.3 months p = 0.0013) but not for metastatic HCC (8.1 vs. 6.8 months p = 0.6300), but PFS was similar. Better clinical outcomes were seen in BCLC C patients who received treatment compliant with NCCS guidelines than in patients with treatment only allowed by BCLC guidelines (median OS 14.2 vs. 7.4 months p = 0.0002; median PFS 6.1 vs. 4.0 months p = 0.0286). Clinical outcomes were, however, similar for patients across all HKLC stages receiving NCCS-recommended treatment regardless of whether their treatment was allowed by HKLC.The high overall compliance rate and satisfactory clinical outcomes of patients managed according to the NCCS guidelines confirm its validity. This validation using real-world data considers patient and treating clinician preferences, thus providing a realistic analysis of the usefulness of the NCCS guidelines when applied in the clinics.
Abstract 16613: The Effect Of The California Wildfires On Daily Step Counts
Authors: David G Rosenthal, Geoffrey H Tison, Robert Avram, Eric Vittinghoff, Mark J Pletcher, Jeffrey E Olgin, Donald J Grandis, Gregory M Marcus
Journal: Circulation (2019)

Introduction: Recent California wildfire seasons have been the largest and most destructive in state history, resulting in prolonged public exposure to poor air quality. Engaging in physical activi...
Outcome in one-vessel coronary artery disease.
Authors: R MCaliff, YTomabechi, K LLee, HPhillips, D BPryor, F EHarrell, P JHarris, R HPeter, V SBehar, YKong, R ARosati
Journal: Circulation (1983)

We analyzed the clinical outcomes in 688 patients with isolated stenosis of one major coronary artery. The survival rate among patients with disease of the right coronary artery (RCA) was higher than that among patients with left anterior descending (LAD) or left circumflex coronary artery (LCA) disease. The survival rate among patients in all three anatomic subgroups exceeded 90% at 5 years. The presence of a lesion proximal to the first septal perforator of the LAD was associated with decreased survival compared with the presence of a more distal lesion. For the entire group of one-vessel disease patients, total ischemic events (death and nonfatal infarction) occurred at similar rates regardless of the anatomic location of the lesion. Left ventricular ejection fraction was the baseline descriptor most strongly associated with survival, and the characteristics of the angina had the strongest relationship with nonfatal myocardial infarction. No differences in survival or total cardiac event rates were fou...
Exercise training confers anticipatory protection from sudden death during acute myocardial ischemia.
Authors: S SHull, EVanoli, P BAdamson, R LVerrier, R DForeman, P JSchwartz
Journal: Circulation (1994)

Seven conscious dogs documented to be at high risk by the occurrence of ventricular fibrillation (VF) during acute myocardial ischemia were randomly assigned to 6 weeks of either daily exercise training or cage rest followed by exercise training. After 6 weeks of daily treadmill training, heart rate variability, a marker of vagal tone, increased by 74% (P < .001); baroreflex sensitivity, a marker of the capability to reflexly augment vagal activity, increased by 69% (P < .01); the repetitive extrasystole threshold, a marker of ventricular electrical stability, increased by 44% (P < .05). After exercise training, the incidence of ventricular fibrillation during acute myocardial ischemia decreased by 100%, as all animals survived. Neither passage of time nor heart rate level during ischemia contributed to the outcome. The most likely mechanism to explain the striking change in risk status is the shift in autonomic balance characterized by increased cardiac vagal activity, which was previously shown to have ...
Indium 111-monoclonal antimyosin antibody imaging in the diagnosis of acute myocarditis.
Authors: TYasuda, I FPalacios, G WDec, J TFallon, H KGold, R CLeinbach, H WStrauss, B AKhaw, EHaber
Journal: Circulation (1987)

A definitive diagnosis of myocarditis requires right ventricular biopsy. Despite its specificity, however, right ventricular biopsy may lack sensitivity due to the focal nature of the disease. Because indium 111-monoclonal antimyosin antibody imaging can be used to detect myocardial necrosis, this procedure was performed on 28 patients clinically suspected of having myocarditis, 25 of whom had left ventricular ejection fractions of less than 45%, and the results were compared with those of right ventricular biopsy performed within 48 hr of the scan. Antimyosin scans were positive in nine patients who had evidence of myocarditis on right ventricular biopsy, and negative in 11 who had no evidence of myocarditis by biopsy. The remaining eight had positive antimyosin scans but showed no evidence of myocarditis on right ventricular biopsy. On the basis of a right ventricular biopsy standard, the sensitivity of this method was 100%, the specificity 58%. We conclude that antimyosin antibody imaging is a reliable...
TCTAP A-044 Deep Learning Segmentation of Lumen and Vessel on IVUS Images
Authors: Jung-Eun Park, Jihoon Kweon, Do-Yoon Kang, Pil Hyung Lee, Jung-Min Ahn, Soo-Jin Kang, Duk-Woo Park, Seung-Whan Lee, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park, Young-Hak Kim
Journal: Journal of the American College of Cardiology (2021)
Angiotensin converting enzyme inhibition in patients with congestive heart failure.
Authors: HGavras, D PFaxon, JBerkoben, H RBrunner, T JRyan
Journal: Circulation (1978)

The etiology of afterload elevation in congestive cardiac failure is unclear, but experimental evidence suggests a role for the renin-angiotensin system in maintaining elevated peripheral vascular resistance. The angiotensin converting enzyme inhibitor SQ20,881 was administered to eight patients with congestive cardiac failure (four hypertensives, four normotensives) during or one day after diagnostic cardiac catheterization. Various hemodynamic measurements performed before and during blockade indicate that this agent caused improvement in cardiac function in all patients by decreasing afterload. This improvement correlated with the decrease in total vascular resistance but was independent of the baseline blood pressure and plasma renin activity. These results suggest that inhibition of angiotensin converting enzyme is a worthwhile approach to the treatment of congestive heart failure, although its exact mechanism of action remains unclear.
Are the kinetics of technetium-99m methoxyisobutyl isonitrile affected by cell metabolism and viability?
Authors: R SBeanlands, FDawood, W HWen, P RMcLaughlin, JButany, GD'Amati, P PLiu
Journal: Circulation (1990)

To investigate the role of cell viability and metabolism on the myocardial kinetics of a new tracer, technetium-99m-methoxyisobutyl isonitrile (Tc-99m-MIBI), 250 microCi/l Tc-99m-MIBI was infused in isolated rat hearts under constant flow conditions. The hearts were studied after inducing irreversible damage by cytochrome c oxidase inhibitor sodium cyanide (n = 8) or sarcolemmal membrane detergent Triton X-100 (n = 8). The control hearts (n = 6) received no toxins. Mean Tc-99m-MIBI peak accumulation activity was significantly reduced after cyanide (51.1 +/- 44.2% of control, p less than 0.01) and Triton (13.8 +/- 2.7% of control, p less than 0.001) administration. Kinetic studies also showed marked reduction in accumulation rates and marked increase in clearance rates for cyanide (p less than 0.01) and Triton (p less than 0.01) groups compared with controls. Potential changes in regional flow distribution were assessed using microspheres. When peak accumulation activity was corrected for these changes, th...
Sleep-stage regulation of ventricular arrhythmias in the unanesthetized pig.
Authors: J ESkinner, D NMohr, PKellaway
Journal: Circulation Research (1975)

In two groups of purebred juvenile Hampshire pigs, left anterior descending coronary occluders were implanted. The pigs were then adapted to the recording chamber until they would manifest a criterion pattern of sleep while in it. In group A, permanent coronary artery occlusions were produced, and the effects of various sleep stages on the resultant cardiac arrhythmias were observed. Sleep intervals during which transitional and slow wave (SW) sleep alternated were correlated with increased arrhythmias relative to the awake state (P less than 0.04). The increase was maximum during sustained periods of SW sleep. Intervals during which rapid eye movement (REM) sleep predominated were correlated with a reduction in arrhythmias. In group B, temporary occlusions were made during both an awake condition and after criterion patterns of either SW or REM sleep. Occlusions after SW sleep reduced the ventricular fibrillation latency compared with that during the awake control state (P less than 0.05), whereas occlus...
Left ventricular performance and regional blood flows before and after ductus arteriosus occlusion in premature lambs treated with surfactant.
Authors: B GBaylen, HOgata, MIkegami, H CJacobs, A HJobe, G CEmmanouilides
Journal: Circulation (1983)

The hemodynamic consequences of patent ductus arteriosus (PDA) were studied during the first few hours of life (1.9 +/- 0.7 hours) in 13 mechanically ventilated, surfactant-treated, preterm lambs (gestational age of 120-124 days). Cardiovascular pressures, left ventricular (LV) performance and regional blood flows were measured using cine left ventriculography and radionuclide-labeled microspheres before and after occlusion of the PDA with a catheter balloon. Before occlusion, the left-to-right shunt was 44 +/- 13%; after occlusion the shunt was negligible (2%). Heart rate (164 +/- 17 beats/min), LV end-diastolic pressure (5 +/- 3 mm Hg), ejection fraction (74 +/- 8%) and cardiac output (241 +/- 13 ml . min-1 . kg-1) were normal and did not change after ductus occlusion. However, effective systemic blood flow increased significantly after occlusion (130 +/- 53 vs 228 +/- 93 ml . min-1 . kg-1, p less than 0.001), as did blood flow to organs such as the brain, myocardium and gastrointestinal tract. The re...
Noninvasive Markers Predicting Variceal Size: The Role Of Lok Score
Authors: M Ayari, Y Zaimi, A Mensi, E Bel Hadj Mabrouk, S Ayadi, Y Said, L Mouelhi, R Dabbeche
Journal: Endoscopy (2021)

Aims Upper gastrointestinal endoscopy is the gold standard method to detect esophageal varices. However, in some cases endoscopy could not be performed or be postponed because of technical difficulties or patient-related factors, and thus diagnosis and treatment may be delayed. The aim of our study was to investigate the correlation between noninvasive scores and variceal size.
Response by Boyd et al to Letter Regarding Article, “Association Between Fetal Congenital Heart Defects and Maternal Risk of Hypertensive Disorders of Pregnancy in the Same Pregnancy and Across Pregnancies”
Authors: Heather A. Boyd, Saima Basit, Jan Wohlfahrt, Nina Øyen
Journal: Circulation (2017)

method also allowed us to investigate the sensitivity of our results to varying heart defect prevalences among stillborn babies.
Reperfusion arrhythmias in isolated perfused pig hearts. Inhomogeneities in extracellular potassium, ST and TQ potentials, and transmembrane action potentials.
Authors: RCoronel, F JWilms-Schopman, TOpthof, JCinca, J WFiolet, M JJanse
Journal: Circulation Research (1992)

We recorded direct current electrograms and local [K+]o at multiple sites and transmembrane potentials at selected sites during reperfusion after 5 minutes and 10 minutes of regional ischemia in isolated perfused pig hearts. After 10 minutes of ischemia, the incidence of ventricular fibrillation (VF) was 38%. At 80-90 seconds after reperfusion, [K+]o was 0.8 mM less than in normal tissue in half of the reperfused tissue, especially in the border zone. This was associated with TQ elevation of +4.5 mV and large peaked T waves. The latter was caused by an abrupt decrease of action potential duration in reperfused tissue, leading to a difference of up to 165 msec with normal tissue. Reperfusion VF started with a closely coupled ventricular premature beat. Activation block between reperfused and normal tissue permitted reentrant activation, leading to VF. Pretreatment with ryanodine (10(-6) M) and reperfusion with elevated [K+] (both of which prevent delayed afterdepolarizations) did not prevent closely couple...
Origin of the third heart sound. II. Studies in human subjects.
Authors: YOzawa, DSmith, ECraige
Journal: Circulation (1983)

We report noninvasive and invasive studies designed to clarify the mechanism of the third heart sound (S3) in humans. The noninvasive observations were made using a miniature accelerometer attached to the skin surface at the cardiac apex. In subjects with no S3, the tracings were either flat or showed very low undulations throughout diastole. Those with an S3, however, demonstrated a distinct reduction of acceleration, or negative jerk, of the rapid filling movement at the apex at the time of the sound. The invasive studies in the cardiac catheterization laboratory consisted of frame-by-frame measurements of left ventricular dimensions in the transverse and long axes during early diastole in patients with diastolic overload abnormalities to investigate the temporal sequence of filling in these two principal axes. The maximal long-axis filling rate occurred after the short axis, a finding that helps to resolve a discrepancy noted in the time of maximal short-axis filling and S3 production. These studies su...
Endothelium-dependent relaxation of hypertensive resistance arteries is not impaired under all conditions.
Authors: JLi, R DBukoski
Journal: Circulation Research (1993)

Endothelium-dependent relaxation of mesenteric resistance arteries of spontaneously hypertensive rats (SHRs) and normotensive Wistar-Kyoto (WKY) rats was studied. Acetylcholine-induced relaxation of SHR vessels precontracted with 10 microM norepinephrine was endothelium dependent and attenuated compared with WKY vessels. The impaired response of SHR vessels was normalized by inhibition of cyclooxygenase with indomethacin. Blockade of nitric oxide synthetase with NG-nitro L-arginine methyl ester (L-NAME) or inhibition of guanylate cyclase with methylene blue attenuated acetylcholine-induced relaxation of norepinephrine-contracted SHR vessels but had no effect on WKY vessels. When vessels were precontracted with 30 nM arginine vasopressin, acetylcholine induced similar degrees of relaxation in both strains. A similar response was detected when lysine vasopressin was used to induce tone. Indomethacin had no effect on relaxation responses of SHR and WKY vessels precontracted with either form of vasopressin. L...
Functional significance of collaterals during ameroid-induced coronary stenosis in conscious dogs. Interrelationships among regional shortening, regional flow and grade of coronary stenosis.
Authors: HTomoike, TInou, KWatanabe, MMizukami, YKikuchi, MNakamura
Journal: Circulation (1983)

We studied the relationships among collateral flow, regional myocardial shortening and the grade of coronary stenosis during ameroid-induced chronic coronary constriction in 22 conscious dogs. A radiolucent ameroid, a Doppler flow probe and a cuff occluder were placed on the left circumflex coronary artery (LCx). Regional myocardial shortening and regional myocardial blood flow were assessed simultaneously using ultrasonic dimension gauges and the tracer microsphere technique, respectively, during temporary occlusion of the LCx. Regional hypokinesia and ischemia were attenuated as a function of time during progressive coronary stenosis. Fifty percent recovery and full recovery of regional shortening during occlusion were observed 19 +/- 3 and 25 +/- 4 days after instrumentation, respectively, when the endocardial blood flow recovered from 0.42 +/- 0.07 ml/min/g at 7 days to 0.56 +/- 0.07 and 0.80 +/- 0.05 ml/min/g, respectively. Greater than 75% coronary stenosis coincided with collateral development, as ...
Phasic vascular sodium pump changes in deoxycorticosterone-hypertensive rats.
Authors: ESongu-Mize, S LBealer, R WCaldwell
Journal: Circulation Research (1984)

We determined the sodium pump activity, measured as ouabain-sensitive 86Rb+ uptake, in the tail arteries of rats treated with deoxycorticosterone and sodium chloride for 6, 9, 14, 28, and 50 days. Systolic blood pressures, plasma sodium, potassium, and creatinine concentrations were measured, and the body weights were recorded. Vascular sodium pump activity was suppressed (by 27%) at the 6th day of deoxycorticosterone and sodium chloride treatment, a prehypertensive state. By the 9th day, blood pressure of deoxycorticosterone-treated and sodium chloride rats had increased, but sodium pump activity was not different from that of control animals. However, increases in sodium pump activity were noted after 14 and 28 days of deoxycorticosterone and sodium chloride treatment (18 and 21%, respectively). By 28 days, a fully developed hypertension was noted. At 50 days, rats displayed lower vascular sodium pump activity (by 23%) than the controls. These rats, although hypertensive, had significantly lower systoli...
Suppression of plasma renin activity by indomethacin in man.
Authors: J CFrölich, J WHollifield, J CDormois, B LFrölich, HSeyberth, A MMichelakis, J AOates
Journal: Circulation Research (1976)

The effect of indomethacin or placebo on aldosterone, plasma renin activity (PRA), sodium excretion, and urinary prostaglandin (PG) levels was investigated in five hypertensive subjects in 100 mEq sodium balance who had experienced malignant hypertension with a disturbance of their renin-aldosterone relationship in the past. Indomethacin significantly lowered aldosterone levels by 43%, PRA by 58%, 24-hour sodium excretion by 49%, and urinary PG excretion, an indicator of renal PG synthesis, by 67%. Angiotensin infusion increased aldosterone to the same level before and after treatment with indomethacin. Similarly, in normal subjects in 150 mEq sodium balance, indomethacin lowered PRA by 47%; sodium excretion fell by 33%, and urinary prostaglandin E (PGE) excretion, by 55%. The acute elevation in PRA 10 minutes after intravenous furosemide was completely abolished by indomethacin. Five subjects with essential hypertension were classified as normal renin hypertensives according to their response to orally a...
154P Intracranial efficacy of alectinib in ALK-positive NSCLC patients with CNS metastases: A multicenter retrospective study
Authors: Z. Zou, P. Xing, X. Hao, Y. Wang, L. Shan, C. Zhang, X. Song, K. Ma, Z. Liu, G. Dong, J. Li
Journal: Journal of Thoracic Oncology (2021)
Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.
Authors: C EMurry, R BJennings, K AReimer
Journal: Circulation (1986)

We have previously shown that a brief episode of ischemia slows the rate of ATP depletion during subsequent ischemic episodes. Additionally, intermittent reperfusion may be beneficial to the myocardium by washing out catabolites that have accumulated during ischemia. Thus, we proposed that multiple brief ischemic episodes might actually protect the heart from a subsequent sustained ischemic insult. To test this hypothesis, two sets of experiments were performed. In the first set, one group of dogs (n = 7) was preconditioned with four 5 min circumflex occlusions, each separated by 5 min of reperfusion, followed by a sustained 40 min occlusion. The control group (n = 5) received a single 40 min occlusion. In the second study, an identical preconditioning protocol was followed, and animals (n = 9) then received a sustained 3 hr occlusion. Control animals (n = 7) received a single 3 hr occlusion. Animals were allowed 4 days of reperfusion thereafter. Histologic infarct size then was measured and was related t...
Profiles in Trauma.
Journal: Annals of Internal Medicine (1969)

wellorganized manner. This chapter should be required reading for all allergists. The remaining chapters are Be¬ haviour of Mouse Mast Cells During Anaphylaxis in Vitro by Vaz and Prouvost-Danon, Immunochemical Reactions of Lipids by Rapport and Graf, and Autoimmunity to Heart and its Relation to Heart Disease: A Review by Kaplan. These topics are presented in a concise fashion, and all have practical as well as funda¬ mental application. An extensive bibliography follows each chapter. This book should serve as an excellent reference source for these subiects under discussion. LTC Robert E. Reisman, MC, USA Fort Sam Houston, Tex