tbuckley/cabot-search huggingface dataset:
15078 Neurodevelopment in patients with atopic dermatitis of a third-level hospital in Mexico
Authors: Karen Adilene Camargo-Sánchez, Toledo-Bahena Mirna, Antonio Rizzoli-Cordoba, Adriana María Valencia-Herrera, Juan Jose Luis Sienra-Monge, Mario Duarte-Abdala, Carlos Alfredo Mena Cedillos
Journal: Journal of the American Academy of Dermatology (2020)
Pollens derived magnetic porous particles for adsorption of low-density lipoprotein from plasma
Authors: Yuetong Wang, Lingyu Sun, Jiahui Guo, Keqing Shi, Luoran Shang, Jian Xiao, Yuanjin Zhao
Journal: Bioactive Materials (2020)

Adsorption of low-density lipoprotein from plasma is vital for the treatment of dyslipidemia. Appropriate adsorbent material for efficient and selective adsorption of low-density lipoprotein is highly desired. In this work, we developed pollens-derived magnetic porous particles as adsorbents for this purpose. The natural pollen grains were modified to obtain high surface porosity, a large inner cavity, magnet responsiveness, and specific wettability. The resultant particles exhibited satisfying performance in the adsorption of a series of oils and organic solvents out of water. Besides, the particles were directly utilized to the adsorption of low-density lipoprotein in plasma, which showed high selectivity, and achieved an outstanding adsorption capacity as high as 34.9% within 2 h. Moreover, their salient biocompatibility was demonstrated through simulative hemoperfusion experiments. These features, together with its abundant source and facile fabrication, makes the pollens-derived magnetic porous particles excellent candidate for low-density lipoprotein -apheresis and water treatment applications.
15188 Clinical responses by self-reported PsA status at baseline among patients with moderate to severe psoriasis treated with guselkumab versus secukinumab: Week 48 results from the ECLIPSE study
Authors: Kristian Reich, Alice B. Gottlieb, Lyn Guenther, Ron Vender, Peter Foley, Susan K. Flavin, Ming-Chun Hsu, Yin You, Bruce Randazzo, Andrew Blauvelt
Journal: Journal of the American Academy of Dermatology (2020)
Author Correction: Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin
Authors: Mari Saif, Wilhelmus J. Kwanten, Jessica A. Carr, Ivy X. Chen, Jessica M. Posada, Amitabh Srivastava, Juanye Zhang, Yi Zheng, Matthias Pinter, Sampurna Chatterjee, Samir Softic, C. Ronald Kahn, Klaus van Leyen, Oliver T. Bruns, Rakesh K. Jain, Moungi G. Bawendi
Journal: Nature Biomedical Engineering (2020)
Succinyl-CoA Ligase Deficiency in Pro-inflammatory and Tissue-Invasive T Cells
Authors: Bowen Wu, Jingtao Qiu, Tuantuan V. Zhao, Yanan Wang, Toshihisa Maeda, Isabel N. Goronzy, Mitsuhiro Akiyama, Shozo Ohtsuki, Ke Jin, Lu Tian, Jörg J. Goronzy, Cornelia M. Weyand
Journal: Cell Metabolism (2020)
Vaping May Be Hazardous to Your Eye
Authors: Cindy Ocran, Edward Chaum, Rachel K. Sobel
Journal: Ophthalmology (2020)

A 71-year-old man presented with left eye pain and vision loss 6 days after tripping and hitting his face on a table. In hindsight, he realized that the mouthpiece of his vape pen had broken off but could not find it. Computed tomography scan revealed orbital floor fracture and orbital foreign body juxtaposed to the globe (Fig A). Examinations was notable for proptosis, ophthalmoplegia, afferent pupillary defect, and light perception vision. B-scan ultrasonography revealed a large suprachoroidal hemorrhage. Using malleable retractors and Adson forceps, the tip was removed from the entry wound in the inferomedial conjunctival fornix (Fig B, C). (Magnified version of Fig A-C is available online at www.aaojournal.org).
COVID-19 alters thinking and management in metabolic diseases
Authors: Carel W. le Roux
Journal: Nature Reviews Endocrinology (2020)

Metabolic diseases emerged as important risk factors for severe COVID-19, but the mechanisms responsible remained unclear for some time. The severity of metabolic diseases was also associated with worse outcomes in patients with COVID-19, forcing clinicians to adjust their thinking on which patients with metabolic disease, but without COVID-19, to prioritize for treatment during and immediately after the pandemic.
Treating Advanced Head and Neck Cancer When Cisplatin Is Not an Option
Authors: Sachin R. Jhawar, Marcelo Bonomi, Paul M. Harari
Journal: Journal of Clinical Oncology (2020)

The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors’ suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice.
129P Exploration of the best candidates for splenic hilar lymph node dissection (No.10 LND) based on long-term survival: Stage IIIA proximal gastric cancer may benefit from No.10 LND
Authors: Z-K. Wang, Y-H. Tang, Q. Zhong, J-X. Lin, Y-Q. Huang, J-W. Xie, J-B. Wang, J. Lu, Q-Y. Chen, L-L. Cao, M. Lin, R-H. Tu, Z-N. Huang, J-L. Lin, H-L. Zheng, C-H. Zheng, C. Huang, P. Li
Journal: Annals of Oncology (2020)
Abstract 17343: E-cigarette Aerosol Exposure Acutely Alters Cardiac Conduction and Autonomic Balance and Induces Arrhythmia in Mice
Authors: Alex P Carll, Meredith D Miles, Emily ONeill, Nima Talebi, Jeff Zurita, Aruni Bhatnagar, Daniel J Conklin
Journal: Circulation (2020)

Background: E-cigarette (e-cig) use has rapidly increased, especially among youth. Vaping has been linked to adverse cardiopulmonary effects, but the full extent of effects remains unknown. Several constituents in e-cigs may increase cardiac risk partly by disturbing cardiac electrophysiology and the autonomic nervous system. Hypothesis: E-cig aerosols will differentially induce pro-arrhythmic changes in cardiac conduction and autonomic balance in mice depending on the presence of nicotine and flavors. Methods: Electrocardiograms (ECGs) were collected by telemetry in 5 healthy male mice (C57BL/6) exposed for 6 hours to clean air or e-cig aerosols (9-minute puff sessions every 18 minutes) from JUUL e-liquids (Va. Tobacco, Mango, or Menthol at ≈5% nicotine benzoate), or a nicotine-free mixture of propylene glycol and vegetable glycerin solvents (PG:VG, 30:70 ratio). ECG morphology, heart rate variability (HRV), and arrhythmias were analyzed by mixed models with P &lt; 0.05 (vs. Air) for all effects. Results: PG:VG increased high grade supraventricular block arrhythmias (121±45 events/hour) relative to Air (0±0 events/hour) and decreased heart rate (HR, -25±8 beats/min), whereas aerosols from all nicotine-containing e-liquids increased HR and decreased HRV, suggesting sympatho-excitation. However, these effects were significantly attenuated for Mango relative to Menthol and Va. Tobacco. As well, only PG:VG and Mango increased ventricular premature beats (VPBs, 9.6±3.7 and 5.5±1.2 events/hour, ±SEM) relative to Air (1.1±0.24 events/hour). VPBs correlated with changes in standard deviation of RR and mean HR from pre-exposure (Spearman’s r : 0.51 and -0.27, P &lt; 0.0001). Prolonged repolarization (QTc) correlated with VPBs during exposures to PG:VG ( r = 0.38, P = 0.046), but not nicotine-containing e-liquids ( r = 0.15, P = 0.38). Conclusions: E-cigs may increase risk for cardiac arrhythmia through e-liquid solvents, which when thermally aerosolized generate toxic aldehydes and particulates. Nicotine and flavor chemicals may modify the cardiac and autonomic impacts of e-cigs. Further studies are needed to determine how e-cig aerosols induce cardiac arrhythmia and whether these effects translate to cardiac morbidity and mortality in humans.
266O Combination ipilimumab and nivolumab in recurrent/metastatic nasopharyngeal carcinoma (R/M NPC): Updated efficacy and safety analysis of NCT03097939
Authors: H-F. Kao, M-K. Ang, Q.S. Ng, D.S.W. Tan, W. Tan, T. Rajasekaran, A. Jain, B-C. Liao, S.H. Tan, E-H. Tan, N.G. Iyer, M.L.K. Chua, R-L. Hong, D.W-T. Lim
Journal: Annals of Oncology (2020)
Association between asthma and clinical mortality/morbidity in COVID‐19 patients using clinical epidemiologic data from Korean Disease Control and Prevention
Authors: Hyo‐Geun Choi, Jee Hye Wee, So Young Kim, Joo‐Hee Kim, Hwan Il Kim, Ji‐Young Park, Sunghoon Park, Yong Il Hwang, Seung Hun Jang, Ki‐Suck Jung
Journal: Allergy (2020)

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Pathogenesis of Cholangiocarcinoma
Authors: Pedro M. Rodrigues, Paula Olaizola, Nuno A. Paiva, Irene Olaizola, Alona Agirre-Lizaso, Ana Landa, Luis Bujanda, Maria J. Perugorria, Jesus M. Banales
Journal: Annual Review of Pathology Mechanisms of Disease (2020)

Cholangiocarcinoma (CCA) encompasses a group of malignancies that can arise at any point in the biliary tree. Although considered a rare cancer, the incidence of CCA is increasing globally. The silent and asymptomatic nature of these tumors, particularly in their early stages, in combination with their high aggressiveness, intra- and intertumor heterogeneity, and chemoresistance, significantly compromises the efficacy of current therapeutic options, contributing to a dismal prognosis. During the last few years, increasing efforts have been made to unveil the etiologies and pathogenesis of these tumors and to develop more effective therapies. In this review, we summarize current findings in the field of CCA, mainly focusing on the mechanisms of pathogenesis, cells of origin, genomic and epigenetic abnormalities, molecular alterations, chemoresistance, and therapies.
Artificial Intelligence Based Blood Pressure Estimation From Auscultatory and Oscillometric Waveforms: A Methodological Review
Authors: Ahmadreza Argha, Branko G. Celler, Nigel H. Lovell
Journal: IEEE Reviews in Biomedical Engineering (2020)

Cardiovascular disease is known as the number one cause of death globally, with elevated blood pressure (BP) being the single largest risk factor. Hence, BP is an important physiological parameter used as an indicator of cardiovascular health. The use of automated non-invasive blood pressure (NIBP) measurement devices is growing, as they can be used without expertise and BP measurement can be performed by patients at home. Non-invasive cuff-based monitoring is the dominant method for BP measurement. While the oscillometric technique is most common, some automated NIBP measurement methods have been developed based on the auscultatory technique. By utilizing (relatively) large BP data annotated by experts, models can be trained using machine learning and statistical concepts to develop novel NIBP estimation algorithms. Amongst artificial intelligence (AI) techniques, deep learning has received increasing attention in different fields due to its strength in data classification and feature extraction problems. This paper reviews AI-based BP estimation methods with a focus on recent advances in deep learning-based approaches within the field. Various architectures and methodologies proposed todate are discussed to clarify their strengths and weaknesses. Based on the literature reviewed, deep learning brings plausible benefits to the field of BP estimation. We also discuss some limitations which can hinder the widespread adoption of deep learning in the field and suggest frameworks to overcome these challenges.
Vascular Calcification, Diabetes, and Cardiovascular Disease: Connecting the Dots⁎⁎Editorials published in JACC: Cardiovascular Imaging reflect the views of the authors and do not necessarily represent the views of JACC: Cardiovascular Imaging or the American College of Cardiology.
Authors: Jason C. Kovacic, Valentin Fuster
Journal: JACC. Cardiovascular imaging (2012)
Functional Magnetic Resonance Imaging–Guided Personalization of Transcranial Magnetic Stimulation Treatment for Depression
Authors: Robin F. H. Cash, Luca Cocchi, Jinglei Lv, Paul B. Fitzgerald, Andrew Zalesky
Journal: JAMA Psychiatry (2020)

This study assesses whether treatment response for depression could be improved via a single one-site-fits-all dorsolateral prefrontal cortex target, representing the group average optimal site of subgenual cingulate cortex functional connectivity, or whether target site personalization is necessary.
Targeting Bfl-1 via acute CDK9 inhibition overcomes intrinsic BH3-mimetic resistance in lymphomas
Authors: Scott Boiko, Theresa Proia, Maryann San Martin, Gareth P. Gregory, Michelle Min Wu, Neeraj Aryal, Maureen Hattersley, Wenlin Shao, Jamal C. Saeh, Stephen E. Fawell, Ricky W. Johnstone, Lisa Drew, Justin Cidado
Journal: Blood (2020)
糖尿病男性でアルコール摂取は制限すべきか:NIPPON DATA80
Authors: Nakamura Yasuyuki, Ueshima Hirotsugu, Kadota Aya, Hozawa Atsushi, Okamura Tomonori, Kadowaki Sayaka, Kadowaki Takashi, Hayakawa Takehito, Kita Yoshikuni, Abbott Robert, Okayama Akira
Journal: Circulation (2008)
Quantification of pulmonary perfusion in idiopathic pulmonary fibrosis with first pass dynamic contrast-enhanced perfusion MRI
Authors: Nicholas D Weatherley, James A Eaden, Paul J C Hughes, Matthew Austin, Laurie Smith, Jody Bray, Helen Marshall, Stephen Renshaw, Stephen M Bianchi, Jim M Wild
Journal: Thorax (2020)

Introduction Idiopathic pulmonary fibrosis (IPF) is a fatal disease of lung scarring. Many patients later develop raised pulmonary vascular pressures, sometimes disproportionate to the interstitial disease. Previous therapeutic approaches that have targeted pulmonary vascular changes have not demonstrated clinical efficacy, and quantitative assessment of regional pulmonary vascular involvement using perfusion imaging may provide a biomarker for further therapeutic insights. Methods We studied 23 participants with IPF, using dynamic contrast-enhanced MRI (DCE-MRI) and pulmonary function tests, including forced vital capacity (FVC), transfer factor (TL CO ) and coefficient (K CO ) of the lungs for carbon monoxide. DCE-MRI parametric maps were generated including the full width at half maximum (FWHM) of the bolus transit time through the lungs. Key metrics used were mean (FWHM mean ) and heterogeneity (FWHM IQR ). Nineteen participants returned at 6 months for repeat assessment. Results Spearman correlation coefficients were identified between TL CO and FWHM IQR (r=−0.46; p=0.026), K CO and FWHM mean (r=−0.42; p=0.047) and K CO and FWHM IQR (r=−0.51; p=0.013) at baseline. No statistically significant correlations were seen between FVC and DCE-MRI metrics. Follow-up at 6 months demonstrated statistically significant decline in FVC (p=0.040) and K CO (p=0.014), with an increase in FWHM mean (p=0.040), but no significant changes in TL CO (p=0.090) nor FWHM IQR (p=0.821). Conclusions DCE-MRI first pass perfusion demonstrates correlations with existing physiological gas exchange metrics, suggesting that capillary perfusion deficit (as well as impaired interstitial diffusion) may contribute to gas exchange limitation in IPF. FWHM mean showed a significant increase over a 6-month period and has potential as a quantitative biomarker of pulmonary vascular disease progression in IPF.
16292 Dupilumab treatment for up to 3 years demonstrates sustained efficacy in adult patients with moderate to severe atopic dermatitis: Results from LIBERTY AD Adult OLE
Authors: Andrew Blauvelt, Iftikhar Hussain, Bethany A. Beazley, Naimish Patel, Sanofi Genzyme, Marcella Ruddy, Heribert Staudinger, Neil M.H. Graham, None BradShumel
Journal: Journal of the American Academy of Dermatology (2020)
15058 The effect of baricitinib on daily and workplace activity from phase 3 trials BREEZE-AD1 and BREEZE-AD2 in adult patients with moderate to severe atopic dermatitis
Authors: Lawrence F. Eichenfield, Jonathan I. Silverberg, José-Manuel Carrascosa, Diana Rubel, Steven Watts, Marta Casillas, Amy M. DeLozier, Evangeline Pierce
Journal: Journal of the American Academy of Dermatology (2020)
The Evolutionary Dynamics of Genetic Incompatibilities Introduced by Duplicated Genes in <i>Arabidopsis thaliana</i>
Authors: Wen-Biao Jiao, Vipul Patel, Jonas Klasen, Fang Liu, Petra Pecinkova, Marina Ferrand, Isabelle Gy, Christine Camilleri, Sigi Effgen, Maarten Koornneef, Ales Pecinka, Olivier Loudet, Korbinian Schneeberger
Journal: Molecular Biology and Evolution (2020)

Although gene duplications provide genetic backup and allow genomic changes under relaxed selection, they may potentially limit gene flow. When different copies of a duplicated gene are pseudofunctionalized in different genotypes, genetic incompatibilities can arise in their hybrid offspring. Although such cases have been reported after manual crosses, it remains unclear whether they occur in nature and how they affect natural populations. Here, we identified four duplicated-gene based incompatibilities including one previously not reported within an artificial Arabidopsis intercross population. Unexpectedly, however, for each of the genetic incompatibilities we also identified the incompatible alleles in natural populations based on the genomes of 1,135 Arabidopsis accessions published by the 1001 Genomes Project. Using the presence of incompatible allele combinations as phenotypes for GWAS, we mapped genomic regions that included additional gene copies which likely rescue the genetic incompatibility. Reconstructing the geographic origins and evolutionary trajectories of the individual alleles suggested that incompatible alleles frequently coexist, even in geographically closed regions, and that their effects can be overcome by additional gene copies collectively shaping the evolutionary dynamics of duplicated genes during population history.
Abstract 15418: Deferral of Care Due to Healthcare Costs in the Uninsured With Atherosclerotic Cardiovascular Disease in the United States, 2006-2015
Authors: Rohan Khera, Javier Valero-Elizondo, Anshul Saxena, Javed Butler, Zainab Samad, Salim S Virani, Sandeep Das, James de Lemos, Harlan M Krumholz, Khurram Nasir
Journal: Circulation (2018)

Background: Healthcare costs pose a major challenge for patients with atherosclerotic cardiovascular disease (ASCVD), particularly those without insurance. It is critical to evaluate whether the un...
Effects and mechanism of platelet-rich plasma on military drill injury: a review
Authors: Peng-Cheng Xu, Min Xuan, Biao Cheng
Journal: Military Medical Research (2020)

Military drill injury is a significant part of military medical research. The increase of training intensity and changes in training methods lead to differences in injury types. The ideal therapeutic modality should allow rapid healing at a reasonable cost and minimize impact on patients' life. Platelet -rich plasma (PRP), a platelet concentrate, is rich in a variety of growth factors and widely used clinically as a minimally invasive treatment. It plays an important role in injury repair and rehabilitation. In this article, we review the therapeutic role of PRP in military drill injury and its possible underlying mechanisms, with a focus on plantar fasciitis, stress fractures and other common injuries, in order to provide basic support for military reserve.
Sex Differences in HIV Testing — 20 PEPFAR-Supported Sub-Saharan African Countries, 2019
Authors: Bakary Drammeh, Amy Medley, Helen Dale, Anindya K. De, Shane Diekman, Randy Yee, Tiffiany Aholou, Arielle Lasry, Andrew Auld, Brittney Baack, Wayne Duffus, Ebrahim Shahul, Vincent Wong, Michael Grillo, Teeb Al-Samarrai, Shabeen Ally, Mtemwa Nyangulu, Rose Nyirenda, Jacobus Olivier, Thato Chidarikire, Nompumelelo Khanyile, Alick A. Kayange, Oscar Ernest Rwabiyago, Upendo Kategile, Jema Bisimba, Rachel A. Weber, Gertrude Ncube, Onesimo Maguwu, Ismelda Pietersen, Denis Mali, Edington Dzinotyiweyi, Lisa Nelson, Matovu John Bosco, Kwarisiima Dalsone, Madina Apolot, Samson Anangwe, Leonard K. Soo, Mary Mugambi, Andre Mbayiha, Placidie Mugwaneza, Samuel S. Malamba, Arlene Phiri, Tina Chisenga, Mary Boyd, Chanie Temesgan, Mesfin Shimelis, Teklu Weldegebreal, Mirtie Getachew, Shirish Balachandra, Ehui Eboi, Willibord Shasha, Nicole Doumatey, Didier Adjoua, Chidozie Meribe, Jerry Gwamna, Pamela Gado, Ima John-Dada, Elie Mukinda, Luc F. Kamanga Lukusa, Lucien Kalenga, Sudhir Bunga, Victoria Achyut, John Mondi, Peter Loeto, Goabaone Mogomotsi, Jenny Ledikwe, Puleng Ramphalla, Mphotleng Tlhomola, Justine K. Mirembe, Tse Nkwoh, Laura Eno, Leonard Bonono, Nely Honwana, Noela Chicuecue, Ana Simbine, Inacio Malimane, Lenhle Dube, Munamato Mirira, Phumzile Mndzebele, Alean Frawley, Yolanda Marina Rebello Cardo, Stephanie Behel
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

Despite progress toward controlling the human immunodeficiency virus (HIV) epidemic, testing gaps remain, particularly among men and young persons in sub-Saharan Africa (1).This observational study used routinely collected programmatic data from 20 African countries reported to the U.S. President's Emergency Plan for AIDS Relief (PEPFAR) from October 2018 to September 2019 to assess HIV testing coverage and case finding among adults (defined as persons aged ≥15 years).Indicators included number of HIV tests conducted, number of HIV-positive test results, and percentage positivity rate.Overall, the majority of countries reported higher HIV case finding among women than among men.However, a slightly higher percentage positivity was recorded among men (4.7%) than among women (4.1%).Provider-initiated counseling and testing (PITC) in health facilities identified approximately two thirds of all new cases, but index testing had the highest percentage positivity in all countries among both sexes.Yields from voluntary counseling and testing (VCT) and mobile testing varied by sex and by country.These findings highlight the need to identify and implement the most efficient strategies for HIV case finding in these countries to close coverage Continuing Education examination available at https://www.cdc.gov/mmwr/mmwr_continuingEducation.html