tbuckley/cabot-search huggingface dataset:
The Mitral Valve: A Pluridisciplinary Approach.
Authors: Jean Haddad, Daniel Kalmanson
Journal: Annals of Internal Medicine (1977)

REVIEWSThe second part of the book relates to clinical applications.The various types of gastrointestinal endoscopy are well covered, including newer procedures such as endoscopic polypectomy, choledochoscopy and retro- grade cholangiopancreatography.Pediatric endoscopy as well as laparoscopy also are well covered.Sections on both gynecologic endoscopy and thoracic endoscopy are fairly extensive and procedures using both rigid and fiberoptic flexible instruments are discussed.Special topics including nephroscopy, arthroscopy, stereoencephaloscopy and retroperitoneoscopy are also covered.These subjects are discussed by specialists in their respective fields and there are 58 coauthors.
Back Cover Image, Volume 41, Issue 6
Authors: Aysun Çapcı, Lars Herrmann, Halmuthur M. Sampath Kumar, Tony Fröhlich, Svetlana B. Tsogoeva
Journal: Medicinal Research Reviews (2021)

The cover image is based on the Review Article Artemisinin-derived dimers from a chemical perspective by Aysun Çapcı et al., https://doi.org/10.1002/med.21814.
Incorrect Study Name
Authors: Ricardo Cohen, Tiago Pereira, Carel Wynnad Le Roux
Journal: JAMA Surgery (2020)

evidence indicates that ITT-based analyses provide the least biased estimate than other approaches such as modified ITT and per protocol analyses 4 Ganesananthan et al were concerned about external validity, because the surgery was undertaken by a single, highly experienced surgeon in a single center.This is a valid point, but we are reassured that RYGB performed across the world is standardized, with subtle technical changes that do not interfere with safety or efficacy.Thus, it is very likely that any experienced bariatric surgeon would be able to reproduce these results.The concerns regarding long-term adverse effects in both groups will be addressed during the 5-year follow-up, but we hope that as CKD will decrease in both groups, harmful effects will not be amplified by CKD.The longer-term follow-up will also address concerns regarding meaningful kidney outcomes and the financial implications of treating patients similar to the cohort studied.
Magnetic resonance imaging of the abdomen and pelvis. Council on Scientific Affairs
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Errors in Byline and Author Contributions
Journal: JAMA Pediatrics (2021)

Emily Feinberg, ScD, CPNP; Marilyn Augustyn, MD; Sarabeth Broder-Fingert, MD, MPH; Amanda Bennett, MD, MPH; Carol Weitzman, MD; Jocelyn Kuhn, PhD; Emily Hickey, PhD; Andrea Chu, MPH; Julia Levinson, MSc; Jenna Sandler Eilenberg, MA, MPH; Michael Silverstein, MD, MPH; Howard J. Cabral, PhD; Gregory Patts, MPH; Yaminette Diaz-Linhart, MSW, MPH; Ivys Fernandez-Pastrana, JD; Jessica Rosenberg, MPH; Judith S. Miller, PhD; James P. Guevara, MD, MPH; Ada M. Fenick, MD; Nathan J. Blum, MD
A Manual of Surgical Treatment.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The use of supercytokines, immunocytokines, engager cytokines, and other synthetic cytokines in immunotherapy
Authors: Xiaohu Zheng, Yaqi Wu, Jiacheng Bi, Yingying Huang, Ying Cheng, Yangyang Li, Yuwei Wu, Guoshuai Cao, Zhigang Tian
Journal: Cellular and Molecular Immunology (2022)
Oral rehydration therapy for viral gastroenteritis
Authors: F. A. Rhoads
Journal: JAMA (1993)

<h3>In Reply.</h3> —Dr Silver raises two points in his response to my article: one is the definition of medical ethics; the other is the question of physician self-interest. With respect to a definition of medical ethics, there is reason for confusion. The term is variously used by medical ethicists. Since I used the term in the title of my paper, I should at least clarify what I meant. Ethics is defined as the science of human conduct. Specifically, today, it is a branch of philosophy consisting in a formal, systematic, critical examination of human conduct from the point of view of its rightness or wrongness, good or harm. Ethics seeks to discern whether there are universalizable principles by which human conduct may be judged. It seeks to clarify the meaning of ethical terms and the logic of ethical discourse and to lay bare the prelogical presuppositions on which ethical opinion
The Beak of the Finch
Authors: Jonathan Weiner
Journal: Annals of Internal Medicine (1997)

Updates1 December 1997The Beak of the FinchJonathan WeinerJonathan WeinerNew York: Vintage; 1994Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-11-199712010-00010 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In most places on this Planet, the sight of a dead bird is so rare that it shocks us, even scares us. We recoil as if something has gone wrong in the cosmos, as if a shutter has creaked open that should have been kept closed, exposing a shadow world beyond our world, a place we were not meant to see.But on the desert island of Daphne Major, dead birds are commonplace. They are everywhere. The lava is always littered with wishbones and beaked skulls. Whole seabirds lie outstretched here and there as if still in flight, odorless and ... Author, Article, and Disclosure InformationAffiliations: New York: Vintage; 1994 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1997Volume 127, Issue 11Page: 1005KeywordsFallsShockSkull ePublished: 15 August 2000 Issue Published: 1 December 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
ETIOLOGY OF INSANITY
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Toxicological Properties of Lead
Authors: Terri Damstra
Journal: Environmental Health Perspectives (1977)

The pathological effects of lead on the renal, nervous, reproductive, endocrine, and immune systems have been reviewed. Emphasis is placed on reported subclinical effects due to chronic, low-level lead exposure. The crucial issue of whether subtle behavioral, intellectual, and developmental impairment occurs in young children, as a result of lead-induced CNS damage is discussed in detail. This issue remains unresolved. Further studies are needed in order to determine the long-term health effects of continuous, low-level lead exposure.
Optimal discriminative value of troponin-I for 6 month cardiac event rate in the evaluation for suspected acute coronary syndromes Vincent Roolvink, Hans E. Luijten, Marc A. Brouwer, G�rard J. H. Uijen, Ries de Keijzer, Tjeerd van der Werf, Freek W. A. Verheugt. Heartcenter, University Medical Center, Nijmegen, The Netherlands
Journal: Journal of the American College of Cardiology (2001)
Tom Nolan's research reviews—7 January 2022
Authors: Tom Nolan
Journal: BMJ (2022)

A grumbling appendixWhat do you get if you cross acute appendicitis with an antibiotic?The Comparison of Outcomes of Antibiotic Drugs and Appendectomy (CODA) trial in 2020 found that antibiotic therapy was non-inferior to surgery in a measure of general health at 30 days for adults with acute appendicitis.It also found no difference in severe adverse events, and only 29% of patients went on to have an appendicectomy by 90 days.Now longer term data from the study-sadly published as a research letter rather than an appendix-finds that, after one year, appendicectomy rates climb to 40%-and 46% at two years. 1 A useful video to aid shared decision making accompanies the letter.If patients increasingly choose conservative management, we might start to see an upsurge in the use of the term "grumbling appendix"; if nothing else, it's a decent punchline for a geeky medic joke.What do you call a microbiologist on a surgical ward round?1
JAMA Oncology
Journal: JAMA Oncology (2020)

JAMA Oncology is committed to publishing infl uential original research, opinions, and reviews that advance the science of oncology and improve the clinical care of patients with cancer.Mission Statement JAMA Oncology is the defi nitive journal for scientists, clinicians, and trainees in the fi eld of oncology worldwide.Our original, innovative, and timely scientifi c and educational content provides a deeper understanding of cancer pathogenesis and recent treatment advances for our readers.JAMA Oncology aims to eff ectively convey the fi ndings of important clinical research, major scientifi c breakthroughs, actionable discoveries, and state-of-the-art treatment pathways to the oncology community.Our goal is that successful communication of new knowledge will ultimately translate to clinical benefi t for people living with and surviving cancer.
Correction to Lancet Infect Dis 2021; published online Feb 8. https://doi.org/10.1016/S1473-3099(21)00078-5
Journal: The Lancet Infectious Diseases (2021)

this Correspondence, the second sentence of the third paragraph should be "As of the end of January, 2021, the spread of N501Y, B.1.1.7 variants has been detected in SARS-CoV-2 isolate genomes from nearly 60 additional countries using CovMT (appendix)."This correction has been made to the online version as of March 1, 2021, and will be made to the printed version.
Pertussis Outbreak Among Adults at an Oil Refinery—Illinois, August-October 2002
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diabetes Distress in Young Adults With Youth-Onset Type 2 Diabetes: TODAY2 Study Results
Authors: Paula M. Trief, Diane Uschner, Melinda Tung, Marsha D. Marcus, Maria Rayas, Sarah MacLeish, Ryan Farrell, Joyce Keady, Lily Chao, Ruth S. Weinstock
Journal: Diabetes Care (2022)

OBJECTIVE To assess the prevalence of high diabetes distress and associated factors in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY2) study cohort of young adults with youth-onset type 2 diabetes. RESEARCH DESIGN AND METHODS Participants completed the Diabetes Distress Scale (DDS) at end-of-study visits. Factors examined for association with high distress were demographic (sex, race/ethnicity, age, education, income), medical (HbA1c, BMI, complications), psychological (depressive and anxiety symptoms), and social (number in household, offspring, health care coverage, established with diabetes care provider). Univariate logistic regression identified factors associated with high distress that were controlled for in multivariate logistic regressions. RESULTS Of 438 participants, 66% were female (mean age 26.8 years, 18% non-Hispanic White, 37% non-Hispanic Black, 38% Hispanic). High distress (DDS ≥2) was reported by 105 (24%) participants. Subscales identified 40% with high regimen distress and 29.7% with high emotional burden. A greater percentage of those with high distress were female (P = 0.002), diagnosed with hypertension (P = 0.037) and retinopathy (P = 0.005), treated with insulin, had higher HbA1c, and had moderate to severe depressive and anxiety symptoms (all P &amp;lt; 0.001). In multivariate analyses, female sex (P &amp;lt; 0.001), HbA1c (P &amp;lt; 0.001), anxiety symptoms (P = 0.036), and lack of health care coverage (P = 0.019) were associated with high distress, after controlling for potential confounders. Moderate to severe depressive symptoms were associated with high regimen distress (P = 0.018) and emotional burden (P &amp;lt; 0.001); insulin treatment was associated with high emotional burden (P = 0.027). CONCLUSIONS Future research should identify modifiable factors associated with high diabetes distress in young adults with youth-onset type 2 diabetes that may inform distress interventions with this medically vulnerable group.
Establishment and characterization of stable, diverse, fecal-derived in vitro microbial communities that model the intestinal microbiota
Authors: Andrés Aranda-Díaz, Katharine Michelle Ng, Tani Thomsen, Imperio Real-Ramírez, Dylan Dahan, Susannah Dittmar, Carlos Gutierrez Gonzalez, Taylor Chavez, Kimberly S Vasquez, Taylor H Nguyen, Feiqiao Brian Yu, Steven K Higginbottom, Norma F Neff, Joshua E Elias, Justin L Sonnenburg, Kerwyn Casey Huang
Journal: Cell Host & Microbe (2022)
The use of enoxaparin and IIb/IIIa antagonists in acute coronary syndromes, including PCI: Final results of the NICE 3 study James J. Ferguson, Elliott M. Antman, Eric R. Bates, Marc Cohen, Nathan R. Every, Robert A. Harrington, Carl J. Pepine, Pierre Theroux, The NICE 3 Investigators. Texas Heart Institute, Houston, TX
Journal: Journal of the American College of Cardiology (2001)
Plasma-informed minimal residual disease (MRD) assay: A multicenter prospective study in Japanese patients with stage II colorectal cancer.
Authors: Eiji Oki, Koji Ando, Yuichi Hisamatsu, Ryota Nakanishi, Yu Nakaji, Kensuke Kudou, Tetsuya Kusumoto, Yoshinori Kagawa, Weng Chit Ung, Hayato Niiro, Sachiyo Tada, Takashi Hirose
Journal: Journal of Clinical Oncology (2022)

161 Background: ̃80% of stage II colorectal cancer (CRC) can be cured by surgery alone. However, adjuvant chemotherapy is recommended for patients with high risk features such as bowel obstruction, &lt; 12 lymph nodes examined and T4 tumors. Traditional pathological grading and biomarkers such as carcinoembryonic antigen has limited sensitivity. Several reports indicated circulating tumor DNA (ctDNA) may represent a promising prognostic factor to assess MRD as a factor for prediction of recurrence after surgery. Here, we present a proof-of-concept study for the development of a novel plasma-based highly sensitive Next Generation Sequencing (NGS) panel using SafeSEQ technology in operable CRC Japanese patients. Methods: This multicenter prospective study recruited patients diagnosed as operable clinical stage II CRC (n = 46) with pre- and post- (4̃6 weeks) operative plasma samples collected between Nov, 2019 and Jan, 2021. ctDNA were extracted and a 14-gene NGS panel was used to analyze single nucleotide variants (SNVs) and Indels covered by gene-specific amplicons. MRD variant was defined as same variant detected in both pre- and post- operative plasma samples. Tissue NGS by a 500-gene panel was also performed in a small number of tissue samples (n = 5) to compare the concordance of plasma and tissue variants. Results: Pre- and post-operative ctDNA status of 46 patients were analyzed. ctDNA positive was observed in 69.6% (32/46, 95%CI 55.2, 81.0) pre- and 34.8% (16/46, 95%CI 22.7, 49.3) post- samples. AKT1, CTNNB1, NRAS, POLE and PPP2R1A mutation were not detected in this study. TP53 mutation was most frequently detected in both pre- (22/46) and post- (11/46) samples, whereas APC mutation was ranked 2 nd in pre- (15/46) but none in post- samples. A combined 96 variants were detected in all samples, in which 76 of them were &lt; 0.5% mutant allele frequency (MAF). MRD variants were detected in 17.4% (8/46, 95%CI 8.82, 30.99) post- samples. Evaluation of positive percentage agreement between tissue and pre- plasma samples in three patients show that a total 7 variants detected in plasma, and 3 of them were detected in tissue samples. Conclusions: This study assesses the feasibility of a plasma-informed NGS panel by evaluating pre- and post- operative plasma samples. The presence of variants with &lt; 0.5% MAF detected in this study indicate a highly sensitive method is required for accurate MRD detection. Further observation is required to explore the relationship between MRD variant and clinical outcome such as 2-year progression-free survival.
Abstract P056: Sex Differences in the Association of Diabetes With Cardiovascular Disease Outcomes Among African Americans in the Atherosclerosis Risk in Communities (ARIC) Prospective Cohort: 1987-2013
Authors: Kristen M George, Elizabeth Selvin, James S Pankow, B. Gwen Windham, Aaron R Folsom
Journal: Circulation (2017)

Epidemiologic studies have consistently shown in whites that the relative risk of diabetes for coronary heart disease (CHD) is greater for women than for men. However, little is known whether this differential sex association is mirrored among African Americans. We hypothesized that, similar to whites, there would be a multiplicative sex by diabetes interaction for cardiovascular disease (CVD) incidence among African Americans in the ARIC cohort. We conducted a prospective cohort analysis of 14,058, 27% African American and 73% white, participants from the ARIC study initially recruited in 1987-1989 and followed for incident cardiovascular events through 2013. CVD was defined as CHD, total stroke, peripheral artery disease (PAD), or heart failure. Race-specific Poisson regression was used to calculate incidence rates of CVD stratified by diabetes status and sex. Race-specific Cox proportional hazards models were run in three stages; stage 1 examined baseline diabetes status, stage 2 examined baseline diabetes status with the competing risk of non-CVD death, and stage 3 incorporated a time-varying model that updated diabetes status during follow-up and included a competing risk of non-CVD death. At each stage, three sequential models were run adjusting for potential confounders including age, body mass index (BMI), smoking status, physical activity, alcohol consumption, education, hypertension, LDL cholesterol, HDL cholesterol, and kidney function. There were 1,073 incident CVD events among African Americans and 2,475 among whites. In stage 1 analysis among African Americans with baseline diabetes, the CVD incidence rate was nearly identical in women and men, 26.8 and 28.1 per 1000 person years, respectively. Women with diabetes were at 2.3-fold increased hazard (95% CI: 2.0 to 2.7) of CVD compared to women without diabetes after adjustment for age, whereas the corresponding hazard ratio for men was 1.8 (95% CI: 1.5 to 2.1) (p for sex by diabetes interaction=0.014). After full adjustment for potential confounders, the diabetes hazard ratio was attenuated to 2.0 (95% CI: 1.8 to 2.3) in women and remained at 1.8 (95% CI: 1.5 to 2.1) for men (interaction p-value =0.058). This finding of synergy between being a woman and having diabetes on CVD risk was consistent across stages 2 and 3 with marginally significant p-values for interaction. The interaction of diabetes by sex was somewhat weaker among whites. Efforts to prevent diabetes and control CVD risk factors are important to both African American men and women, but are particularly relevant in women. While diabetes and CVD risk factor management have improved over the last several decades, there is a higher relative risk of CVD among African American women with diabetes compared with diabetic men, mirroring the sex differences seen in whites.
Validation of myocardial perfusion grades using digital subtraction angiography (DSA) C. Michael Gibson, Lily L. Luu, Sarah R. Kermgard, Colin A. Hynes, Matthew H.C. Otten, Jessica S. Lim, Mark Appleby, Andrew Michaels, Susan J. Marble, Sabina A. Murphy, Hal V. Barron. University of California San Francisco, San Francisco, CA
Journal: Journal of the American College of Cardiology (2001)