tbuckley/cabot-search huggingface dataset:
Retraction and republication—Worldwide burden of cancer attributable to diabetes and high body-mass index: a comparative risk assessment
Authors: None The Editors of The Lancet Diabetes & Endocrinology
Journal: The Lancet Diabetes & Endocrinology (2018)

On Nov 28, 2017, The Lancet Diabetes & Endocrinology published online a comparative risk assessment that estimated the worldwide burden of cancer attributable to diabetes and high body-mass index, and the Article was published in print in the February, 2018, issue of the journal.1Pearson-Stuttard J Zhou B Kontis V Bentham J Gunter MJ Ezzati M Worldwide burden of cancer attributable to diabetes and high body-mass index: a comparative risk assessment.Lancet Diabetes Endocrinol. 2018; 6: 95-104Summary Full Text Full Text PDF PubMed Scopus (32) Google Scholar On Jan 22, 2018, the authors notified us that the relative risk for mortality for colorectal cancer from one of the study's sources2Tsilidis KK Kasimis JC Lopez DS Ntzani EE Ioannidis JPA Type 2 diabetes and cancer: umbrella review of meta-analyses of observational studies.BMJ. 2015; 350: g7607Crossref PubMed Scopus (481) Google Scholar had been inadvertently used instead of the relative risk for incidence. The Editors of The Lancet Diabetes & Endocrinology discussed the corrections that were needed in the paper and appendix as a result of this mistake. Our decision, in accordance with the Committee on Publication Ethics' guidelines, that because of the extent of the changes necessary, the previous version of the Article should be retracted and a corrected version republished after re-analysis and re-review. Today we retract the previous version and republish online the corrected version of the Article and appendix,3Pearson-Stuttard J Zhou B Kontis V Bentham J Gunter MJ Ezzati M Worldwide burden of cancer attributable to diabetes and high body-mass index: a comparative risk assessment.Lancet Diabetes Endocrinol. 2018; 6: e6-e15Summary Full Text Full Text PDF PubMed Scopus (178) Google Scholar in which the findings have changed slightly—eg, some absolute numbers of cancers attributable to diabetes and high body-mass index have been altered. The overall message remains the same. The previous version of the Article has been added to the appendix in the new version and is marked retracted. Worldwide burden of cancer attributable to diabetes and high body-mass index: a comparative risk assessmentA substantial number of cancer cases are attributable to diabetes and high BMI. As the prevalence of these cancer risk factors increases, clinical and public health efforts should focus on identifying optimal preventive and screening measures for whole populations and individual patients. Full-Text PDF Open AccessRetracted: Worldwide burden of cancer attributable to diabetes and high body-mass index: a comparative risk assessmentA substantial number of cancer cases are attributable to diabetes and high BMI. As the prevalence of these cancer risk factors increases, clinical and public health efforts should focus on identifying optimal preventive and screening measures for whole populations and individual patients. Full-Text PDF Open Access
THE LOUSE PROBLEM AT THE WESTERN FRONT
Authors: A. D. Peacock
Journal: BMJ (1916)

THE insect dealt with in thjis paper is the clotlhes or body louse-Pedicul,as humnanus, Linnaeus; order Anoplcra or BS'iplt clCtlatat.ENTOMOLOGICAL. MORPHOLOGY.Techniqnie.-Microscopical preparations wero made as follows :-the insects were chloroformed, fixed in formalin (10 per cenit.)for a day, brouglht through the alcohols (50 per cent., 70 per cent., 90 per cent., absolute), cleared in xylol for a day or two, and mnounted in Canada balsam.The drawings lhave been carefully prepared, and are as detailed and accturate as opportunity hlas perinitted, but further work will, no doubt, reveal otlher features wlhich may necessitate sliglht additions anid imiodifications.Thle musculatule and moutl parts, for instance, are not fully worked out.The nomenclature of the parts may possibly.need
Translating the Science of Cancer Dormancy to the Clinic
Authors: Julio A. Aguirre-Ghiso
Journal: Cancer Research (2021)

Abstract The paradigm of metastasis has been significantly remodeled by the incorporation of cancer dormancy as a mechanism to explain long-term remission intervals followed by relapse. There is overall consensus on the potential impact of better understanding dormancy. Key cancer-cell autonomous and microenvironmental mechanisms might explain this biology and, in turn, the timing of metastasis. However, the approach and feasibility to apply this biology to clinical trials has been controversial. The discussion here provides insight into how these controversies are being resolved by the development of active clinical trials, thus bringing to reality opportunities to target cancer dormancy.
Measuring Quality
Authors: Todd Gruber, Ben Rudnitsky
Journal: Annals of Internal Medicine (2002)

Letters5 March 2002Measuring QualityTodd Gruber, MD, MPH and Ben Rudnitsky, MDTodd Gruber, MD, MPHMonmouth Medical CenterLong Branch, NJ 07740Search for more papers by this author and Ben Rudnitsky, MDMonmouth Medical CenterLong Branch, NJ 07740Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-5-200203050-w1 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In his recent editorial, Eisenberg (1) cites barriers to performance reports, including those for individual physicians. Because he was commenting on a study in which the data were directly extracted from patient charts (2), another important problem with quality reports was not addressed, namely, the issue of using data extracted from billing databases. Last year, the New Jersey Peer Review Organization (PRO) reported the percentage of diabetic patients cared for by the first author of this letter who had at least one hemoglobin A1c test from 1 April 1998 through 31 March 1999. The PRO database indicated ...Reference1. Eisenberg JM. Measuring quality: are we ready to compare the quality of care among physician groups? Ann Intern Med. 2002;136:153-4. [PMID: 11790069] LinkGoogle Scholar2. Greenfield S, Kaplan SH, Kahn R, Ninomiya J, Griffith JL. Profiling care provided by different groups of physicians: effects of patient case-mix (bias) and physician-level clustering on quality assessment results. Ann Intern Med. 2002;136:111-21. [PMID: 11790062] LinkGoogle Scholar3. Jencks SF, Cuerdon T, Burwen DR, Fleming B, Houck PM, Kussmaul AE, etal; . Quality of medical care delivered to Medicare beneficiaries: a profile at state and national levels. JAMA. 2000;284:1670-6. [PMID: 11015797] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Monmouth Medical CenterLong Branch, NJ 07740 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoProfiling Care Provided by Different Groups of Physicians: Effects of Patient Case-Mix (Bias) and Physician-Level Clustering on Quality Assessment Results Sheldon Greenfield , Sherrie H. Kaplan , Richard Kahn , John Ninomiya , and John L. Griffith Measuring Quality: Are We Ready To Compare the Quality of Care among Physician Groups? John M. Eisenberg Metrics 5 March 2002Volume 136, Issue 5Page: W1KeywordsChartsDatabasesHemoglobinLipid profilesPatientsPeer review ePublished: 5 March 2002 Issue Published: 5 March 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.Loading ...
Facing forwards along the Health Silk Road
Authors: None The Lancet Global Health
Journal: The Lancet Global Health (2017)

Last month, China made a significant move towards the consolidation of its role as a major player in global health policy. At the Belt and Road High-level Meeting for Health Cooperation in Beijing, delegates from between 20 and 30 countries plus WHO, UNAIDS, the GAVI Alliance, and the Global Fund signed a communiqué aimed at increasing collaboration on research, health security, and education among the countries of China's proposed Belt and Road Initiative.
Advisory Board and Contents
Authors: Jerry Madukwe, Jessica Miles, Fred Kop, Patrick Scheffmann, Michelle Arkin, Matthew Banks, Andrew Bate, Mary Bebawy, Jeffrey Benovic, Jacqueline Crawley, Debbie Hay, Stephanie Laszlo, Hunyady Magnus, Ingelman-Sundberg Michael, Kassiou Kum, Kum Khanna, Brian Kobilka, Jenny Lam, Michel Lazdunski, Fiona Marshall, Ruth Nussinov, Avner Schlessinger, Martina Schmidt, Harald Sitte, Rachel Tyndale, Ming-Wei Wang, Stephen Watson, Stephen Waxman, Matthew Webber
Journal: Trends in Pharmacological Sciences (2022)
Acute Myeloid Leukemia Induced Remodelling of the Human Bone Marrow Niche Predicts Clinical Outcome
Authors: Yiyang Chen, Yasmin Zaun, Lucas Arnold, Kerstin Weissenfels, Kurt Werner Schmid, Ludger Klein-Hitpass, Anthony Squire, Stefanie Bertram, Ulrich Duehrsen, Maher Hanoun
Journal: Blood (2018)
Medical Society of the State of Washington.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The association of lung function and pulmonary vasculature volume with cardiorespiratory fitness in the community
Authors: Jenna McNeill, Ariel Chernofsky, Matthew Nayor, Farbod N. Rahaghi, Raul San Jose Estepar, George Washko, Andrew Synn, Ramachandran S. Vasan, George O'Connor, Martin G. Larson, Jennifer E. Ho, Gregory D. Lewis
Journal: European Respiratory Journal (2022)

Background Cardiorespiratory fitness is not limited by pulmonary mechanical reasons in the majority of adults. However, the degree to which lung function contributes to exercise response patterns among ostensibly healthy individuals remains unclear. Methods We examined 2314 Framingham Heart Study participants who underwent cardiopulmonary exercise testing (CPET) and pulmonary function testing. We investigated the association of forced expiratory volume in 1 s (FEV 1 ), forced vital capacity (FVC), FEV 1 /FVC and diffusing capacity of the lung for carbon monoxide ( D LCO ) with the primary outcome of peak oxygen uptake ( V ′ O 2 ) along with other CPET parameters using multivariable linear regression. Finally, we investigated the association of total and peripheral pulmonary blood vessel volume with peak V ′ O 2 . Results We found lower FEV 1 , FVC and D LCO were associated with lower peak V ′ O 2 . For example, a 1 L lower FEV 1 and FVC was associated with a 7.1% (95% CI 5.1–9.1%) and 6.0% (95% CI 4.3–7.7%) lower peak V ′ O 2 , respectively. By contrast, FEV 1 /FVC was not associated with peak V ′ O 2 . Lower lung function was associated with lower oxygen uptake efficiency slope, oxygen pulse slope, V ′ O 2 at anaerobic threshold (AT), minute ventilation ( V ′ E ) at AT and breathing reserve. In addition, lower total and peripheral pulmonary blood vessel volume were associated with lower peak V ′ O 2 . Conclusions In a large, community-based cohort of adults, we found lower FEV 1 , FVC and D LCO were associated with lower exercise capacity, as well as oxygen uptake efficiency slope and ventilatory efficiency. In addition, lower total and peripheral pulmonary blood vessel volume were associated with lower peak V ′ O 2 . These findings underscore the importance of lung function and blood vessel volume as contributors to overall exercise capacity.
Contact tracing: digital health on the frontline
Authors: None The Lancet Digital Health
Journal: The Lancet Digital Health (2020)

South Korea, China, and Singapore have successfully used digital contact tracing to control the spread of COVID-19, often putting public interest above individuals' right to privacy. Despite initial enthusiasm for this approach in the USA, Israel, and Europe, privacy concerns and technical issues inhibited uptake of digital contact tracing, and recent attempts to stem the first wave of SARS-COV-2 infections failed.
Bioinspired Andrias davidianus-Derived wound dressings for localized drug-elution
Authors: Xiang Liu, Xiang Mao, Guo Ye, Menghong Wang, Ke Xue, Yan Zhang, Hongmei Zhang, Xiaoqiao Ning, Man Zhao, Jinlin Song, Yu Shrike Zhang, Ximu Zhang
Journal: Bioactive Materials (2022)

Local drug delivery has received increasing attention in recent years. However, the therapeutic efficacy of local delivery of drugs is still limited under certain scenarios, such as in the oral cavity or in wound beds after resection of tumors. In this study, we introduce a bioinspired adhesive hydrogel derived from the skin secretions of Andrias davidianus (SSAD) as a wound dressing for localized drug elution. The hydrogel was loaded with aminoguanidine or doxorubicin, and its controlled drug release and healing-promoting properties were verified in a diabetic rat palatal mucosal defect model and a C57BL/6 mouse melanoma-bearing model, respectively. The results showed that SSAD hydrogels with different pore sizes could release drugs in a controllable manner and accelerate wound healing. Transcriptome analyses of the palatal mucosa suggested that SSAD could significantly upregulate pathways linked to cell adhesion and extracellular matrix deposition and had the ability to recruit keratinocyte stem cells to defect sites. Taken together, these findings indicate that property-controllable SSAD hydrogels could be a promising biofunctional wound dressing for local drug delivery and promotion of wound healing.
Pathogenic germline mutations prevalence in Saudi patients with pancreatic ductal adenocarcinoma.
Authors: Mohammed Ahmed Algarni, Kanan Alshammari, Ashwaq Al Olayan, Fouad Sabatin, Nadine Mabsout, Horya Zaher, Husam Shehata, Saeed Al Turki
Journal: Journal of Clinical Oncology (2022)

538 Background: While the majority of pancreatic ductal adenocarcinoma(PDAC) cases are sporadic, about 10% related to familial and hereditary component. Multiple studies have shown that germline genetic testing regardless of family history for patients with PDCA is feasible and more likely to identify the carrier of pathogenic mutations. There is no data about the prevalence of pathogenic germline mutations in Saudi population. We aimed to study the prevalence of these mutations in Saudi patient patients with PDAC regardless of the family history of cancer. Methods: By using our cancer genetics database, we analyzed all the confirmed cases of PDAC who were referred to the cancer genetic clinic at King Abdulaziz medical city in Riyadh, Kingdom of Saudi Arabia. Since November 2018, a comprehensive hereditary cancer gene panel (including 70 genes) is offered to all referred PDAC cases regardless of their family history of cancer after obtaining a genetic counselling assessment and an informed consent. Results: Between November 2018 and August 2021, a total of 88 patients with PDAC cases have been tested. The median age was 60 and the majority of patients were males (n=56, 64%). Most of the patients had stage IV disease (n=75, 85.23%). The genetic result was available for 86 patients. Pathogenic variant(PVs) was reported in 8.1% (n=7), variant of uncertain significance (VUSs) was reported in 15% (n=13) while no mutation reported in the rest of the patients. The PVs reported were BRCA2 (n=4), BRIP1 (n=1), PMS1(n=1) and MRE11 (n=1). All the carriers of the PVs had no documented family history of breast, ovarian or pancreatic cancers at the time of genetic counselling. Conclusions: This study confirms the importance of genetic testing in all patients with PDAC regardless of the family history. This is in line with previous studies from other populations. This is the first study from Saudi patients with PDAC and to the best of our knowledge, the first study in Arab population.
Evaluation of Interventions to Reduce Opioid Prescribing for Patients Discharged From the Emergency Department
Authors: Raoul Daoust, Jean Paquet, Martin Marquis, Jean-Marc Chauny, David Williamson, Vérilibe Huard, Caroline Arbour, Marcel Émond, Alexis Cournoyer
Journal: JAMA Network Open (2022)

Limiting opioid overprescribing in the emergency department (ED) may be associated with decreases in diversion and misuse.
Predictive factors for renal function deterioration during palliative first-line chemotherapy for metastatic colorectal cancer.
Authors: AhReum Lim, Jwa Hoon Kim, Myung Han Hyun, Yeul Hong Kim, Soohyeon Lee
Journal: Journal of Clinical Oncology (2022)

85 Background: Effective first-line therapy is a key determinant of treatment outcomes and should be selected after considering both clinical factors and biological markers in metastatic colorectal cancer (mCRC). Considering the increased number of cancer patients with old age and their chronic diseases, it is essential to select a therapeutic agent by evaluating the toxicity that may occur due to long-term chemotherapy. This study assessed changes in renal function for 1 year in patients diagnosed with mCRC during chemotherapy and analyzed the factors and effect of each chemotherapy regimen on renal function. Methods: We retrospectively investigated patients with mCRC treated with palliative 1st line chemotherapy at our institution from 2015 to 2020. According to the common 1st line treatment regimen, we divided into 4 groups; FOLFOX/FOLFIRI with bevacizumab/cetuximab. We checked the baseline renal function and 3, 6, 9 and 12 months after the start of chemotherapy. The change in estimated glomerular filtration rate (△eGFR) was calculated as [(eGFR at each time point) - (eGFR at baseline)/(eGFR at baseline) X 100]. The clinical factors such as age, gender, chronic disease, BMI (body mass index), disease status, baseline proteinuria, and 1st line chemotherapy regimen were evaluated. Proteinuria was detected on urine dipstick protein ≥ 1+. Additionally, predictors for ΔeGFR ≤ −30% at each time points after therapy initiation were evaluated using multivariate logistic regression analysis. Results: Among 466 mCRC patients, the median eGFR values at baseline was 95.4 ml/min/1.73m 2 . The median eGFR at 6 months after chemotherapy initiation were significantly lower than baseline (88.3 ml/min/1.73m 2 , p &lt; 0.001). As 1 year, patients with more than 30% worsening of renal function was observed in 27.6 % in FOLFIRI + bevacizumab, 26.3 % in FOLFOX + bevacizumab, 6.6 % in FOLFIRI + cetuximab, and 4.7 % in FOLFOX + cetuximab group. The FOLFIRI + bevacizumab was an independent predictor for ΔeGFR ≤ −30% at 6 months (odds ratio (OR) 1.94, 95% confidence interval (CI) 1.05-3.47, p = 0.034) along with old age (≥ 65 years, OR 2.18, 95% CI 1.29-3.68, p = 0.004) and BMI (p = 0.012). Additionally, FOLFIRI + bevacizumab regimen causes more proteinuria (46.4%) than other chemotherapy regimens. Conclusions: Deterioration of renal function was more common with FOLFIRI + bevacizumab than other combination regimen. Old age, BMI were also associated decreasing eGFR. These results will be helpful to be suggested as important consideration when selecting the 1st line chemotherapy regimen for mCRC.
Tropical Ophthalmology.
Authors: D P CHOYCE
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genome-wide analysis and functional annotation of chromatin-enriched noncoding RNAs in rice during somatic cell regeneration
Authors: Yu-Chan Zhang, Yan-Fei Zhou, Yu Cheng, Jia-Hui Huang, Jian-Ping Lian, Lu Yang, Rui-Rui He, Meng-Qi Lei, Yu-Wei Liu, Chao Yuan, Wen-Long Zhao, Shi Xiao, Yue-Qin Chen
Journal: Genome biology (2022)

Abstract Background Plants have the remarkable ability to generate callus, a pluripotent cell mass that acquires competence for subsequent tissue regeneration. Global chromatin remodeling is required for this cell fate transition, but how the process is regulated is not fully understood. Chromatin-enriched noncoding RNAs (cheRNAs) are thought to play important roles in maintaining chromatin state. However, whether cheRNAs participate in somatic cell regeneration in plants has not yet been clarified. Results To uncover the characteristics and functions of cheRNAs during somatic cell reprogramming in plants, we systematically investigate cheRNAs during callus induction, proliferation and regeneration in rice. We identify 2284 cheRNAs, most of which are novel long non-coding RNAs or small nucleolar RNAs. These cheRNAs, which are highly conserved across plant species, shuttle between chromatin and the nucleoplasm during somatic cell regeneration. They positively regulate the expression of neighboring genes via specific RNA motifs, which may interact with DNA motifs around cheRNA loci. Large-scale mutant analysis shows that cheRNAs are associated with plant size and seed morphology. Further detailed functional investigation of two che-lncRNAs demonstrates that their loss of function impairs cell dedifferentiation and plant regeneration, highlighting the functions of cheRNAs in regulating the expression of neighboring genes via specific motifs. These findings support cis - regulatory roles of cheRNAs in influencing a variety of rice traits. Conclusions cheRNAs are a distinct subclass of regulatory non-coding RNAs that are required for somatic cell regeneration and regulate rice traits. Targeting cheRNAs has great potential for crop trait improvement and breeding in future.