Postmenopausal Hormone Replacement Therapy
Authors: Francine Grodstein, JoAnn E. Manson, Meir J. Stampfer
Journal: Annals of Internal Medicine (2003)

Letters15 April 2003Postmenopausal Hormone Replacement TherapyFrancine Grodstein, ScD, JoAnn E. Manson, MD, and Meir J. Stampfer, MDFrancine Grodstein, ScDBrigham and Women's Hospital; Boston, MA 02215 (Grodstein, Manson)Harvard School of Public Health; Boston, MA 02215 (Stampfer)Search for more papers by this author, JoAnn E. Manson, MDBrigham and Women's Hospital; Boston, MA 02215 (Grodstein, Manson)Harvard School of Public Health; Boston, MA 02215 (Stampfer)Search for more papers by this author, and Meir J. Stampfer, MDBrigham and Women's Hospital; Boston, MA 02215 (Grodstein, Manson)Harvard School of Public Health; Boston, MA 02215 (Stampfer)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-8-200304150-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Humphrey and colleagues (1) claimed incorrectly that the Nurses' Health Study failed to control for socioeconomic status in analyzing postmenopausal hormones and risk for coronary heart disease (CHD). All of our participants are registered nurses, with nearly identical education. Thus, using stratification, we adjusted for profession and education (2) to an equivalent extent as studies that Humphrey and colleagues cited as having adequately adjusted for socioeconomic status. Other large cohorts, such as the Leisure World Study (3), similarly control for confounding by focusing on populations with uniform income and education. Moreover, Humphrey and colleagues incorrectly stated that ...References1. Humphrey LL, Chan BK, Sox HC. Postmenopausal hormone replacement therapy and the primary prevention of cardiovascular disease. Ann Intern Med. 2002;137:273-84. [PMID: 12186518] LinkGoogle Scholar2. Grodstein F, Manson JE, Colditz GA, Willett WC, Speizer FE, Stampfer MJ. A prospective, observational study of postmenopausal hormone therapy and primary prevention of cardiovascular disease. Ann Intern Med. 2000;133:933-41. [PMID: 11119394] LinkGoogle Scholar3. Henderson BE, Paganini-Hill A, Ross RK. Decreased mortality in users of estrogen replacement therapy. Arch Intern Med. 1991;151:75-8. [PMID: 1985611] CrossrefMedlineGoogle Scholar4. Sidney S, Petitti DB, Quesenberry CP. Myocardial infarction and the use of estrogen and estrogen-progestogen in postmenopausal women. Ann Intern Med. 1997;127:501-8. [PMID: 9313017] LinkGoogle Scholar5. Mikkola TS, Clarkson TB. Estrogen replacement therapy, atherosclerosis, and vascular function. Cardiovasc Res. 2002;53:605-19. [PMID: 11861031] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Francine Grodstein, ScD; JoAnn E. Manson, MD; Meir J. Stampfer, MDAffiliations: Brigham and Women's Hospital; Boston, MA 02215 (Grodstein, Manson)Harvard School of Public Health; Boston, MA 02215 (Stampfer) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoA Prospective, Observational Study of Postmenopausal Hormone Therapy and Primary Prevention of Cardiovascular Disease Francine Grodstein , JoAnn E. Manson , Graham A. Colditz , Walter C. Willett , Frank E. Speizer , and Meir J. Stampfer Postmenopausal Hormone Replacement Therapy and the Primary Prevention of Cardiovascular Disease Linda L. Humphrey , Benjamin K.S. Chan , and Harold C. Sox Metrics Cited bySystematic review: Hormone therapy and cardiovascular disease: a systematic review and meta-analysisPostmenopausal hormone therapy and breast cancer: a systematic review and meta-analysisPostmenopausal hormone therapy: Critical reappraisal and a unified hypothesis 15 April 2003Volume 138, Issue 8Page: 688KeywordsAlcoholsCongenital heart diseaseEstrogen replacement therapyExerciseHormonesObservational studiesObstetrics and gynecologyRelative riskRisk managementSocioeconomic status ePublished: 15 April 2003 Issue Published: 15 April 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...