tbuckley/cabot-search huggingface dataset:
ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction
Authors: Jeffrey L. Anderson, Cynthia D. Adams, Elliott M. Antman, Charles R. Bridges, Robert M. Califf, Donald E. Casey, William E. Chavey, Francis M. Fesmire, Judith S. Hochman, Thomas N. Levin, A. Michael Lincoff, Eric D. Peterson, Pierre Theroux, Nanette Kass Wenger, R. Scott Wright, Sidney C. Smith, Alice K. Jacobs, Cynthia D. Adams, Jeffrey L. Anderson, Elliott M. Antman, Jonathan L. Halperin, Sharon A. Hunt, Harlan M. Krumholz, Frederick G. Kushner, Bruce W. Lytle, Rick Nishimura, Joseph P. Ornato, Richard L. Page, Barbara Riegel
Journal: Journal of the American College of Cardiology (2007)
Catheter ablation of atrial tachycardia: do we need to ablate anything that fires? Andrea Natale, Walid I. Saliba, Mina K. Chung, Patrick Tchou, Lon Castle, Mark Niebauer, Logan Kanagaratnam, Cathy Lam, Robert Schweikert, Alejandro Perez-Lugones, Stephen Pavia, Gery Tomassoni. Cleveland Clinic Foundation, Cleveland, OH
Journal: Journal of the American College of Cardiology (2001)
The biologic effects of low-level radiation
Authors: E. Festag
Journal: JAMA (1988)

<h3>To the Editor.</h3> —I wish to comment on the article entitled "Physicians' Obligations in Radiation Issues."<sup>1</sup> Dr Loken errs in stating that "no data from humans exist that show that low-level radiation exposures produce measurable biologic effects." Consider the 1958 study by Stewart et al,<sup>2</sup>the Tristate Leukemia Study,<sup>3</sup>Bertell's<sup>4</sup>work on aging in adults, Mancuso's<sup>5</sup>Hanford findings, and Gofman's<sup>6</sup>analysis of results from the Hiroshima-Nagasaki study, all of which involved low-level radiation and showed measurable effects. Dr Loken's implication that cancer deaths should increase in direct proportion to background levels if there is no threshold is fallacious. In a recent article, Gofman<sup>7</sup>refutes three studies—by Frigerio and Stowe,<sup>8</sup>by Hickey et al,<sup>9</sup>and a Chinese study<sup>10</sup>—based on that concept. The spiderwort work by Nagata et al<sup>11</sup>in Japan strongly suggests that radiation levels around nuclear power plants
Psychiatry
Authors: R. M. Glass
Journal: JAMA (1989)

About 15% of adults in US communities meet diagnostic criteria for psychiatric disorders.<sup>1</sup>These are even more common in both adult<sup>2</sup>and pediatric<sup>3</sup>primary care practices, with respective prevalence rates of 27% and 22%. The impact on medical practice is striking, since nonpsychiatrists account for 83% of physician visits in which psychotropic drugs are prescribed.<sup>4</sup>Hence, we survey some of the recent developments in psychiatric drug treatment. Extensive research documents the efficacy of psychopharmacologic treatments for patients with major depression (who often consult primary care physicians for sleep and appetite disturbance and other somatic complaints) or bipolar disorder, with its episodic mania or submanic moods and depression. Major depression, a potentially lethal disorder that is probably increasing among younger birth cohorts,<sup>5</sup>is often unrecognized or inadequately treated. Accordingly, the National Institute of Mental Health in 1988 launched its Depression/Awareness, Recognition, and Treatment Program, the first
Large-vessel vasculitis
Authors: Dan Pugh, Maira Karabayas, Neil Basu, Maria C. Cid, Ruchika Goel, Carl S. Goodyear, Peter C. Grayson, Stephen P. McAdoo, Justin C. Mason, Catherine Owen, Cornelia M. Weyand, Taryn Youngstein, Neeraj Dhaun
Journal: Nature Reviews Disease Primers (2022)
Searching high and low: call for a joint ESPID-EUCAST survey on dosage of antibacterial agents in children–part one
Authors: David Aguilera-Alonso, Rafael Cantón, Christian G. Giske, Gunnar Kahlmeter, Malte Kohns Vasconcelos, Cihan Papan, John Turnidge
Journal: Clinical Microbiology and Infection (2022)
Abstract P233: Handgrip Strength Modifies the Association Between Body Mass Index and Blood Pressure in Children and Adolescents of the United States: Experience in NHANES 2011-2014
Authors: Rui Zhang, Liqiang Zheng, Wei Chen, Shengxu Li
Journal: Circulation (2017)

Background: Body mass index (BMI), a measure of obesity, is strongly associated with blood pressure (BP) in children and adolescents. Handgrip strength is a measure of muscular strength and body fitness. We hypothesized that handgrip strength modifies the relationship between BMI and BP. Methods: The sample included 3,947 children and adolescents (50.4% boys and 49.6% girls) aged 8-19 years who participated in the National Health and Nutrition Examination Surveys (NHANES) 2011-2014. The sum of the maximum handgrip strength from both hands, standardized to age- and sex-specific z-scores, was used. General linear models were used for data analyses. Results: As expected, BMI was positively correlated with systolic BP (partial correlation coefficient r=0.17, P&lt;0.0001). After adjustment for age, race, sex, and handgrip strength, each BMI unit increase was associated with 0.47 (0.03, standard error) mm Hg increase in systolic BP (P&lt;0.0001). Further, handgrip strength significantly (P=0.0002) attenuated the association between BMI and systolic BP. In those with handgrip strength below the median, each BMI unit increase was associated with 0.59 (0.04) mm Hg increase in systolic BP; such increase was only 0.38 (0.03) mm Hg in those with handgrip strength above the median, representing a 36% reduction in the effect size of BMI on systolic BP. Conclusion: These results suggest that high fitness, measured by handgrip strength, attenuates the adverse effect of obesity on blood pressure levels in children and adolescents, which indicates that increasing muscular strength and body fitness will have beneficial effects on obesity-associated elevated BP in children and adolescents.
Correction: Blood Flow to the Heart during the Menstrual Cycle
Journal: Annals of Internal Medicine (2002)

Letters5 February 2002Correction: Blood Flow to the Heart during the Menstrual CycleSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-3-200202050-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In a recent summary for patients (1) that accompanied the paper by Kawano and colleagues (2), the last sentence in the section ‘What did the researchers find?” should read ‘Ischemia was least frequent in the middle of the menstrual cycle (around the time of ovulation), when estrogen levels were lowest and the blood vessels were most likely to dilate.”References1. Blood flow to the heart varies during the menstrual cycle in premenopausal women with heart disease. Summary for Patients. Ann Intern Med. 2001; 135:I-40. Google Scholar2. Kawano H, Moroyama T, Ohgushi M, Kugiyama K, Ogawa H, Yasue H. Menstrual cyclic variation of myocardial ischemia in premenopausal women with variant angina. Ann Intern Med. 2001;135:977-81. [PMID: 11730398] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMenstrual Cyclic Variation of Myocardial Ischemia in Premenopausal Women with Variant Angina Hiroaki Kawano , Takeshi Motoyama , Masamichi Ohgushi , Kiyotaka Kugiyama , Hisao Ogawa , and Hirofumi Yasue Blood Flow to the Heart Varies during the Menstrual Cycle in Premenopausal Women with Heart Disease Metrics 5 February 2002Volume 136, Issue 3Page: 253KeywordsBlood flowBlood vesselsEstrogensHeartIschemiaMenstrual cycleOvulation ePublished: 5 February 2002 Issue Published: 5 February 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Sir James Mackenzie (1853-1925) beloved clinician
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The British Society of Gastroenterology
Journal: Gut (1966)

Using a method of saline perfusion the rate of accumu- lation of DNA in the stomach was measured in patients with normal gastric mucosa, with pernicious anaemia, and with simple atrophic gastritis.Patients with normal mucosa, or pernicious anaemia, had low DNA rates.A majority of patients with simple atrophic gastritis had much higher values.In gastric biopsy specimens significantly higher epithelial mitosis counts were found in treated pernicious anaemia and simple atrophic gastritis than in normal mucosa.The data appear to indicate a higher turnover of surface epithelial cells in atrophic than in normal gastric mucosa.
index to advertisers
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transcriptomic profiling to identify subsets of immune hot locally advanced rectal adenocarcinomas with favorable outcomes after neoadjuvant treatment.
Authors: Francisco Sanchez Vega, Walid Khaled Chatila, Jin Ki Kim, Henry S. Walch, Michael Marco, Ching-Tung Chen, Fan Wu, Danny Khalil, Karuna Ganesh, Xuan Qu, Anisha Luthra, Seo-Hyun Choi, Yu-jui Ho, Dana Omer, Jinru Shia, Paul Bernard Romesser, Nikolaus Schultz, Rona Yaeger, Jesse Joshua Smith, Julio Garcia-Aguilar
Journal: Journal of Clinical Oncology (2022)

155 Background: Understanding the role of the tumor microenvironment in the response to chemotherapy and radiation in patients with locally advanced rectal cancer (LARC, stage II-III) can lead to the identification of novel immunologic biomarkers to preselect patients who can avoid surgery and benefit from watch-and-wait strategies. Methods: We performed DNA and RNA sequencing of pre-treatment biopsies from 89 LARC patients who received neoadjuvant therapy, including 5 microsatellite unstable (MSI) and 84 microsatellite stable (MSS) patients. We computed single-sample gene set enrichment analysis (ssGSEA) scores for immune infiltrates and signaling pathways implicated in tumor progression. Immunofluorescence and hematoxylin-eosin staining of tumor slides was performed to confirm significant correlations with RNA-Seq estimates of immune markers. Other genomic variables were also included in the analysis, such as tumor mutational burden (TMB), fraction of genome altered by copy number changes, whole genome duplication events and somatic mutations in rectal cancer driver genes and pathways. Results were largely replicated using an independent cohort of 42 LARC samples with publicly available data from The Cancer Genome Atlas (TCGA). Results: Since MSI tumors are known to have a distinct immunologic profile, we separated them into their own group and performed unsupervised hierarchical clustering on the MSS tumors. We identified a set of immune hot MSS tumors (n = 7) with extensive immune infiltration. These tumors had low TMB and were predominantly classified as CMS4 (5/7). None of the 12 patients in the combined MSI and immune hot MSS groups recurred during the length of our study and they had response rates &gt; 50% (vs. &lt; 25% in the rest of MSS patients). MSI and immune hot MSS tumors had lower frequency of TP53 and APC mutations, and they exhibited increased levels of T cell infiltration. In particular, we observed overexpression of markers for Th1 cells, which produce inflammatory cytokines (e.g., IFN-gamma) and are associated with antitumor immunity. Genes encoding protein targets of immune checkpoint blockade, such as PDCD1 (PD-1), CD274 (PD-L1), CTLA4, HAVCR2 (TIM3) and LAG3, were also overexpressed in the immune hot MSS and - to a lesser extent – the MSI tumors, suggesting that these patients might benefit from the use of immune checkpoint inhibitors. Conclusions: Our results uncover a unique LARC tumor immune profile evident in the pre-treatment setting that could be used to better prognosticate rectal cancer patients and develop novel therapeutic strategies.
Food policies: in times of COVID-19 and beyond
Authors: None The Lancet Diabetes & Endocrinology
Journal: The Lancet Diabetes & Endocrinology (2021)

3 billion people were not able to afford a healthy diet before the COVID-19 pandemic and this number is estimated to rise by 267·6 million between 2020 and 2022 according to the 2021 Global Food Policy Report released by the International Food Policy Research Institute. The report details the severe health and economic effects that the COVID-19 pandemic has had on food systems and supply chains and provides key recommendations to help achieve healthy diets for all. With the rise in low quality, nutrition-deficient diets comes the inevitable increase in nutrition-related non-communicable diseases (NCDs), which were already at an unprecedented high before the pandemic.
Erratum
Journal: JNCI Journal of the National Cancer Institute (1997)

“Re: Stage IIIA Category of Non-Small-Cell Lung Cancer: a New Proposal,” by Grunenwald and Le Chevalier [J Natl Cancer Inst 1997;89:88–9 (Issue 1)]. The first of three numbered items in paragraph 2, column 3, page 88 should begin, “1) the subdivision of N2 disease into two subcategories—mN2 ( minimal N2)….”
Association of Daily Sitting Time and Leisure-Time Physical Activity With Survival Among US Cancer Survivors
Authors: Chao Cao, Christine M. Friedenreich, Lin Yang
Journal: JAMA Oncology (2022)

Sedentary behaviors, particularly prolonged sitting and lack of physical activity, may influence survival after cancer.To examine the independent and joint associations of daily sitting time and leisure-time physical activity with mortality outcomes among cancer survivors.A prospective cohort of a nationally representative sample of cancer survivors, age 40 years or older (n = 1535; weighted population, 14 002 666), from the US National Health and Nutrition Examination Survey from 2007 to 2014. Participants were linked to mortality data from their interview and physical examination date through December 31, 2015. Daily sitting time and leisure-time physical activity (LTPA) were self-reported using the Global Physical Activity Questionnaire. Data analyses were performed from January 1 to May 1, 2021.All-cause, cancer-specific, and noncancer mortality.Among 1535 cancer survivors (mean [SE] age, 65.1 [0.4] years; 828 [60.1%] females; 945 [83.1%] non-Hispanic White individuals), 950 (56.8%) reported LTPA of 0 minutes per week (min/wk) during the previous week (inactive); 226 (15.6%) reported LTPA of less than 150 min/wk (insufficiently active); 359 (27.6%) reported LTPA of 150 min/wk or more (active); 553 (35.4%) reported sitting for 6 to 8 hours per day (h/d); and 328 (24.9%) reported sitting for more than 8 h/d. Of note, 574 (35.8%) cancer survivors reported no LTPA with concurrent sitting of more than 6 h/d. During the follow-up period of up to 9 years (median, 4.5 years; 6980 person-years), there were 293 deaths (cancer, 114; heart diseases, 41; other causes, 138). Multivariable models showed that being physically active was associated with lower risks of all-cause (hazard ratio [HR], 0.34; 95% CI, 0.20-0.60) and cancer-specific (HR, 0.32; 95% CI, 0.15-0.70) mortality compared with inactivity. Sitting more than 8 h/d was associated with higher risks of all-cause (HR, 1.81; 95% CI, 1.05-3.14) and cancer-specific (HR, 2.27; 95% CI, 1.08-4.79) mortality compared with those sitting less than 4 h/d. In the joint analyses, prolonged sitting was associated with an increased risk of death among cancer survivors who were not sufficiently active. Specifically, inactive and insufficiently active survivors reported sitting more than 8 h/d had the highest overall (HR, 5.38; 95% CI, 2.99-9.67) and cancer-specific (HR, 4.71; 95% CI, 1.60-13.9) mortality risks.In this cohort study of a nationally representative sample of US cancer survivors, the combination of prolonged sitting with lack of physical activity was highly prevalent and was associated with the highest risks of death from all causes and cancer.
The Surgical and Medical History of the Naval War Between Japan and China, During 1894-1895. Translated from the Original Japanese Report, Under the Direction of Baron Saneyoshi, F.R.C.S. Eng., Director-General of Medical Department of Imperial Japanese Navy, by S. Suzuki, M.R.C.S. Eng., L.r.C.P. Lond., Deputy Inspector-General of Hospitals and Fleets, Imperial Japanese Army.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A comparison of the impact of practice patterns on the outcomes of patients with acute coronary syndromes in the USA and Canada: Post Hoc analysis of ESSENCE and TIMI 11B Wayne B. Batchelor, David Radley, Marc Cohen, Alexander G.G. Turpie, Anatoly Langer, Shaun Goodman. Terrence Donnelly Heart Center, Ontario, Canada
Journal: Journal of the American College of Cardiology (2001)
Carlo Urbani
Authors: Ivan Oransky
Journal: The Lancet (2003)

First to recognise severe acute respiratory syndrome; infectious disease expert for WHO and for Médecins Sans Frontières; treated parasitic diseases in Cambodia, Vietnam, and elsewhere around the world. Born Oct 19, 1956, in Castelplanio, Italy; died of severe acute respiratory syndrome in Bangkok, Thailand, on March 29, 2003, aged 46 years.
From the Editor's Desk...
Authors: Patrizia Burra, Frank Tacke, Vlad Ratziu, Stefan Zeuzem, Bruno Sangro, Paolo Angeli
Journal: Journal of Hepatology (2020)

In the PREDICT study, a European, prospective, observational study, Trebicka et al. aim to characterize the clinical course of acute decompensation (AD) of cirrhosis in 1,071 patients. Three groups of patients were identified: patients with pre-acute-on-chronic liver failure (ACLF), who developed ACLF and had 3-month and 1-year mortality rates of 53.7% and 67.4%, respectively; patients with unstable decompensated cirrhosis who did not develop ACLF but required ≥1 hospital readmission, and had mortality rates of 21.0% and 35.6%, respectively; patients with stable decompensated cirrhosis who neither developed ACLF nor were readmitted, and had a 1-year mortality rate of only 9.5%.
Clinical Summaries
Journal: Circulation (2008)

Deficient Zebrafish Ether-à-Go-Go-Related Gene Channel Gating Causes Short-QT Syndrome in Zebrafish Reggae MutantsVarious genetic defects, primarily in cardiac ion channels, are known to cause human cardiac repolarization disorders such as long-and short-QT syndrome; however, suitable genetic animal models to study disease mechanisms and evaluate new treatment strategies are largely lacking.In search of suitable arrhythmia models, we isolated the zebrafish mutation reggae (reg), which displays clinical features of the malignant human short-QT syndrome such as accelerated cardiac repolarization accompanied by cardiac fibrillation.By positional cloning, we identified the reg mutation that resides within the voltage sensor of the zebrafish ether-à-go-go-related gene (zERG) potassium channel.The mutation causes premature zERG channel activation and defective inactivation, which results in shortened action potential duration and accelerated cardiac repolarization.Consequently, QT intervals in ECGs from heterozygous and homozygous reg mutant adult zebrafish are considerably shorter than in wild-type zebrafish.Hence, with its molecular and pathophysiological concordance to the human arrhythmia syndrome, zebrafish reg represents the first animal model for human short-QT syndrome and may help to further dissect disease mechanisms and to identify new pharmacological treatment options in high-throughput screens.See p 866.
Multifunctional regulatory protein connective tissue growth factor (CTGF): A potential therapeutic target for diverse diseases
Authors: Minyang Fu, Dandan Peng, Tianxia Lan, Yuquan Wei, Xiawei Wei
Journal: Acta Pharmaceutica Sinica B (2022)

Connective tissue growth factor (CTGF), a multifunctional protein of the CCN family, regulates cell proliferation, differentiation, adhesion, and a variety of other biological processes. It is involved in the disease-related pathways such as the Hippo pathway, p53 and nuclear factor kappa-B (NF-κB) pathways and thus contributes to the developments of inflammation, fibrosis, cancer and other diseases as a downstream effector. Therefore, CTGF might be a potential therapeutic target for treating various diseases. In recent years, the research on the potential of CTGF in the treatment of diseases has also been paid more attention. Several drugs targeting CTGF (monoclonal antibodies FG3149 and FG3019) are being assessed by clinical or preclinical trials and have shown promising outcomes. In this review, the cellular events regulated by CTGF, and the relationships between CTGF and pathogenesis of diseases are systematically summarized. In addition, we highlight the current researches, focusing on the preclinical and clinical trials concerned with CTGF as the therapeutic target.