tbuckley/cabot-search huggingface dataset:
Metal-phenolic networks: facile assembled complexes for cancer theranostics
Authors: Wensheng Xie, Zhenhu Guo, Lingyun Zhao, Yen Wei
Journal: Theranostics (2021)

In recent years, metal-phenolic networks (MPNs) have attracted increasing attention for the engineering of multi-functional platforms because of their easy fabrication processes, excellent physicochemical properties, outstanding biocompatibility, and promising theranostic applications. In this review, we summarize recent progress in the design, synthesis, shape-control, biocompatibility evaluation, and potential theranostic applications of MPNs, especially for cancer theranostics. First, we provide an overview of various MPN systems, relevant self-assembly procedures, and shape-controllable preparation. The in vitro and in vivo biocompatibility evaluation of MPNs is also discussed, including co-incubation viability, adhesion, bio-distribution, and inflammation. Finally, we highlight the significant achievements of various MPNs for cancer theranostics, such as tumor imaging, drug delivery, photothermal therapy, radiotherapy, and chemo- and photo-dynamic therapy. This review provides a comprehensive background on the design and controllable synthesis, in vitro and in vivo biocompatibility evaluation, applications of MPNs as cancer theranostic agents, and presents an overview of the most up-to-date achievements in this field.
CAR T-cell therapy in multiple myeloma: more room for improvement
Authors: Phaik Ju Teoh, Wee Joo Chng
Journal: Blood Cancer Journal (2021)

Abstract The emergence of various novel therapies over the last decade has changed the therapeutic landscape for multiple myeloma. While the clinical outcomes have improved significantly, the disease remains incurable, typically in patients with relapsed and refractory disease. Chimeric antigen receptor (CAR) T-cell therapies have achieved remarkable clinical success in B-cell malignancies. This scope of research has more recently been extended to the field of myeloma. While B-cell maturation antigen (BCMA) is currently the most well-studied CAR T antigen target in this disease, many other antigens are also undergoing intensive investigations. Some studies have shown encouraging results, whereas some others have demonstrated unfavorable results due to reasons such as toxicity and lack of clinical efficacy. Herein, we provide an overview of CAR T-cell therapies in myeloma, highlighted what has been achieved over the past decade, including the latest updates from ASH 2020 and discussed some of the challenges faced. Considering the current hits and misses of CAR T therapies, we provide a comprehensive analysis on the current manufacturing technologies, and deliberate on the future of CAR T-cell domain in MM.
MYOCARDIAL INFARCTION RATES BY DEFINITION, TYPE, AND TREATMENT IN THE ISCHEMIA-CKD TRIAL
Authors: Bernard Chaitman, Dennis Kunichoff, Karen Alexander, Radoslaw Pracon, Kevin Bainey, Anoop Mathew, Anjali Acharya, Renato Lopes, Jerome Fleg, Mandeep Sidhu, Frank Rockhold, David Maron, Judith Hochman, Sripal Bangalore
Journal: Journal of the American College of Cardiology (2021)
Abstract 14856: Leadless Pacemaker Implantation in Patients With Paroxysmal Complete Atrioventricular Block
Authors: ivan mendoza, Jorge Penalver, Ninoska N Aranguibel, Chamorro Jose, Juan P zambrano, Ivan Mendoza
Journal: Circulation (2020)

Introduction: Transcatheter pacing systems have recently emerged as a safe and effective alternative in treating patients who require right ventricular pacing therapy. Traditionally, patients with atrial fibrillation with slow ventricular response had been benefit from this therapy. More recent, patients with symptomatic paroxysmal complete AV block had been receiving these devices. At this moment there is no data available about the feasibility , safety or outcomes of leadless pacemaker in this subgroup of patients Objective: The aim of this study was to assess the feasibility safety and 1 year follow up of the transcatheter leadless pacemaker device in patients with paroxysmal complete AV block . Methods: One hundred and ten (110 ) consecutive patients who underwent implantation of a Micra transcatheter leadless pacemaker (LPM)and have been follow up for at least a year were evaluated . Forty one (41) of these patients had the device implanted after experiencing symptomatic paroxysmal complete AV block. A t-test analysis was used to compare patient demographics, total procedure times, complication rates and recaptures necessary during the procedure. Results: All the patients with symptomatic paroxysmal complete AV block were implanted successfully with the leadless pacemaker system ( LPN ) . None of the patients suffered complications during the procedures. Fifty three percent ( 53%) were female , mean age of 77 , mean procedure time was 21.1 min. The mean number of recaptures required were 0.48 . None of the patient experienced pacemaker syndrome or progress to complete AV block after 1 year of follow up Conclusion: Leadless pacemaker implantation appears to be a safe and feasible alternative for subjects with symptomatic paroxysmal complete AV block . Further studies are required in these subgroup of patients
Abstract 18694: Connexin-43 Gene Variants are Associated with Risk of Ventricular Arrhythmias in Patients with a Depressed Ejection Fraction
Authors: Happy Thakkar, Jonathan P Piccini, Albert Y Sun, Carol Haynes, Elizabeth Grass, Kent Nilsson, Jason I Koontz, Patrick Hranitzky, Svati H Shah
Journal: Circulation (2012)

Background: Despite the life-saving benefits of implantable cardioverter defibrillator (ICD) therapy, only a minority of primary prevention patients ultimately receive ICD therapy for ventricular arrhythmias. Genetic risk factors may improve current risk stratification models. Connexin-43 is the predominant component of gap junctions in ventricular myocardium. Accordingly, we hypothesized that common genetic variants in connexin-43 are associated with risk of ventricular arrhythmias in patients with reduced ejection fraction. Methods: Caucasian individuals with an impaired ejection fraction (&lt; 35%) who had received a primary prevention ICD were identified from the Duke Electrophysiology Genetic Studies (EPGEN) database (N=252). Six connexin-43 single-nucleotide polymorphisms (SNPs) were genotyped using Taqman. Association with ventricular arrhythmia, defined as an appropriate ICD shock or anti-tachycardia pacing for ventricular tachycardia or fibrillation, was tested using univariate and multivariable logistic regression models adjusted for sex, age, hypertension, hyperlipidemia, smoking, diabetes and coronary artery disease status. Results: Over a mean follow-up of 2.3 years, there were 42 cases of ventricular arrhythmia. In univariate analyses, two SNPs in complete linkage disequilibrium, rs11961755 and rs10456940, were associated with risk of ventricular arrhythmia (19% of cases vs. 44% of controls carried at least one copy of the minor allele, p=0.003 in the dominant genetic model). In multivariable models, these SNPs were associated with an odds ratio for ventricular arrhythmia of 0.27 (95% confidence interval 0.11-0.62, p=0.002). These relationships were not observed in African-American subjects (N=124). No other connexin-43 SNPs were associated with events. Conclusions: Genetic variants in connexin-43 are independently associated with risk of ventricular arrhythmia in patients referred for primary prevention ICDs. Prospective studies should address whether these novel markers improve risk stratification.
Predictive Factors of Overall Survival and the Completion of Four Cycles of Azacitidine: An MDS-CAN Study
Authors: Danielle N. Blunt, Richard A. Wells, Lisa Chodirker, Ken Rockwood, Michelle Geddes, Nancy Zhu, Jill Fulcher, Mitchell Sabloff, Mary-Margaret Keating, Brian Leber, Heather A. Leitch, Karen W.L. Yee, Eve St-Hilaire, Nicholas G. Finn, John Storring, Thomas J. Nevill, April Shamy, Rajat Kumar, Mohamed Elemary, Robert Delage, Martha Lenis, Alexandre Mamedov, Liying Zhang, Rena Buckstein
Journal: Blood (2017)
T(A)KI-ARRHYTHMIA: THE UNIQUE CONSIDERATIONS IN RATE CONTROL MANAGEMENT OF IBRUTINIB-ASSOCIATED ATRIAL FIBRILLATION
Authors: Gabriel S. Ruiz, Zachary Wilson, Mohamed Abdelhabib, Shaunak Pandya, Danielle Akin, Varun Tandon
Journal: Journal of the American College of Cardiology (2021)
Abstract 12869: The Role of Electrogram Morphology-Based Algorithm (Wavelet) as Predictor of Ventricular Arrhythmia
Authors: Koji Sudo, Yukio Hosaka, Kazuyoshi Takahashi, Takumi Akiyama, Takahiro Hakamata, Kota Nishida, Komei Tanaka, Keiichi Tsuchida, Hirotaka Oda
Journal: Circulation (2018)

Introduction: The electrogram morphology-based algorithm (Wavelet) is useful for discrimination of supraventricular tachycardia (SVT) from ventricular arrhythmia. The inappropriate therapy delivery...
RACIAL DISPARITIES IN ACUTE CORONARY SYNDROME MANAGEMENT WITHIN THE CANADIAN UNIVERSAL HEALTHCARE SYSTEM: INSIGHTS FROM THE AMI-OPTIMA TRIAL
Authors: Marc-Andre D'Entremont, Christina C. Wee, Étienne L. Couture, Michel Nguyen, Samuel Lemaire-Paquette, Marc Afilalo, Jean-Pierre Déry, Mark Eisenberg, Simon Kouz, Philippe L'Allier, Claude Lauzon, Samer Mansour, Martine Montigny, Stéphane Rinfret, Erick Schampaert, Jean Claude Tardif, Thao Huynh
Journal: Journal of the American College of Cardiology (2021)
Frataxin deficiency promotes endothelial senescence in pulmonary hypertension
Authors: Miranda K. Culley, Jingsi Zhao, Yi Yin Tai, Ying Tang, Dror Perk, Vinny Negi, Qiujun Yu, Chen-Shan C. Woodcock, Adam Handen, Gil Speyer, Seungchan Kim, Yen-Chun Lai, Taijyu Satoh, Annie M.M. Watson, Yassmin Al Aaraj, John Sembrat, Mauricio Rojas, Dmitry Goncharov, Elena A. Goncharova, Omar F. Khan, Daniel G. Anderson, James E. Dahlman, Aditi U. Gurkar, Robert Lafyatis, Ahmed U. Fayyaz, Margaret M. Redfield, Mark T. Gladwin, Marlene Rabinovitch, Mingxia Gu, Thomas Bertero, Stephen Y. Chan
Journal: Journal of Clinical Investigation (2021)

The dynamic regulation of endothelial pathophenotypes in pulmonary hypertension (PH) remains undefined. Cellular senescence is linked to PH with intracardiac shunts; however, its regulation across PH subtypes is unknown. Since endothelial deficiency of iron-sulfur (Fe-S) clusters is pathogenic in PH, we hypothesized that a Fe-S biogenesis protein, frataxin (FXN), controls endothelial senescence. An endothelial subpopulation in rodent and patient lungs across PH subtypes exhibited reduced FXN and elevated senescence. In vitro, hypoxic and inflammatory FXN deficiency abrogated activity of endothelial Fe-S-containing polymerases, promoting replication stress, DNA damage response, and senescence. This was also observed in stem cell-derived endothelial cells from Friedreich's ataxia (FRDA), a genetic disease of FXN deficiency, ataxia, and cardiomyopathy, often with PH. In vivo, FXN deficiency-dependent senescence drove vessel inflammation, remodeling, and PH, whereas pharmacologic removal of senescent cells in Fxn-deficient rodents ameliorated PH. These data offer a model of endothelial biology in PH, where FXN deficiency generates a senescent endothelial subpopulation, promoting vascular inflammatory and proliferative signals in other cells to drive disease. These findings also establish an endothelial etiology for PH in FRDA and left heart disease and support therapeutic development of senolytic drugs, reversing effects of Fe-S deficiency across PH subtypes.
THE PROGNOSTIC ROLE OF MATRIX METALLOPROTEINASE 7 (MMP-7) AMONG OLDER ADULTS: ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY
Authors: Ali Agha, Aliza Hussain, Amil Shah, Ron Hoogeveen, Carol Sun, Salim Virani, Vijay Nambi, Bing Yu, Elizabeth Selvin, Kunihiro Matsushita, Leo Buckley, Chen-Sheng Lin, Pranav Dorbala, Christie Ballantyne
Journal: Journal of the American College of Cardiology (2021)
PREVALENCE OF CARDIAC INVOLVEMENT IN HOSPITALIZED PATIENTS WITH COVID-19: ECHOCARDIOGRAPHIC FINDINGS IN A REGISTRY OF 768 PATIENTS
Authors: Payam Pournazari, Alison Spangler, Fawzi Ameer, Kobina Hagan, Lakshmi Chebrolu, Mohammed Chamsi-Pasha, William Zoghbi, Khurram Nasir, Sherif Nagueh
Journal: Journal of the American College of Cardiology (2021)
MITRAL REGURGITATION, SYSTEMIC INFARCTS, AND HYPERCOAGULABILITY: CULTURE NEGATIVE INFECTIVE ENDOCARDITIS OR VALVULAR ANTI-PHOSPHOLIPID SYNDROME
Authors: Haytham Aboushi, Perry Wengrofsky, Jonathan Ramalho, Marie J. Murphy, Inna Bukharovich
Journal: Journal of the American College of Cardiology (2021)
TEN YEARS OF PEDIATRIC CONGENITAL HEART DISEASE SURGERY IN A CARIBBEAN NATION
Authors: Nicola Pradegan, Juan R. Leon, Ysailis Mariñez, Yanet Toribio, Rebeca Pérez, Elias Walid, Fradwikigns Vargas, Cesar Herrera
Journal: Journal of the American College of Cardiology (2021)
SUBCLINICAL CHANGES IN LEFT AND RIGHT VENTRICULAR STRAIN AS DETERMINED BY SPECKLE-TRACKING ECHOCARDIOGRAPHIC ANALYSIS AFTER TRANSCATHETER OR SURGICAL AORTIC-VALVE REPLACEMENT
Authors: Olga N. Kislitsina, Bonnie Kane, Adin-Cristian Andrei, James Thomas, Jane Kruse, Andrei Churyla, Ashvita Ramesh, Ranya Sweis, James Flaherty, Charles Davidson, Patrick McCarthy, S. Chris Malaisrie
Journal: Journal of the American College of Cardiology (2021)
Correspondence on ‘Onset of rheumatoid arthritis after COVID-19: coincidence or connected?’
Authors: Rashmi Roongta, Arghya Chattopadhyay, Alakendu Ghosh
Journal: Annals of the Rheumatic Diseases (2021)

Differences between the stock selection criteria of stock indexes can cause them to behave differently. This study compared the styles of four Islamic indexes from major index providers, whose Shariah screening criteria are at variance. To ensure fairness in comparison, the authors chose Islamic indexes that represent only the U.S. stock market because conditions vary across markets and financial markets have been found to be segmented by countries. Likewise, a fixed set of style benchmarks and T-bills were used as asset classes in determining the style of each Islamic index. A thorough comparison revealed important differences in the styles of the analyzed Islamic indexes, much of which can be attributed to differences in their screening criteria in light of the relevant literature. <b>TOPICS:</b>Security analysis and valuation, ESG investing, emerging
COVID-19 Among Workers in the Seafood Processing Industry: Implications for Prevention Measures — Alaska, March–October 2020
Authors: Kimberly A. Porter, Maya Ramaswamy, Thomas Koloski, Louisa Castrodale, Joseph McLaughlin
Journal: MMWR Morbidity and Mortality Weekly Report (2021)

Large COVID-19 outbreaks have occurred in high-density workplaces, such as food processing facilities (1).Alaska's seafood processing industry attracts approximately 18,000 out-of-state workers annually (2).Many of the state's seafood processing facilities are located in remote areas with limited health care capacity.On March 23, 2020, the governor of Alaska issued a COVID-19 health mandate (HM10) to address health concerns related to the impending influx of workers amid the COVID-19 pandemic (3).HM10 required employers bringing critical infrastructure (essential) workers into Alaska to submit a Community Workforce Protective Plan.*On May 15, 2020, Appendix 1 was added to the mandate, which outlined specific requirements for seafood processors, to reduce the risk for transmission of SARS-CoV-2, the virus that causes COVID-19, in these high-density workplaces (4).These requirements included measures to prevent introduction of SARS-CoV-2 into the workplace, including testing of incoming workers and a 14-day entry quarantine before workers could enter nonquarantine residences.After 13 COVID-19 outbreaks in Alaska seafood processing facilities and on processing vessels during summer and early fall 2020, State of Alaska personnel and CDC field assignees reviewed the state's seafood processing-associated cases.Requirements were amended in November 2020 to address gaps in COVID-19 prevention.These revised requirements included restricting quarantine groups to ≤10 persons, pretransfer testing, and serial testing (5).Vaccination of this essential workforce is important (6); until high vaccination coverage rates are achieved, other mitigation strategies are needed in this high-risk setting.Updating industry guidance will be important as more information becomes available.On May 15, 2020, the state issued HM10 Appendix 1, detailing three entry quarantine options for onshore seafood processors: 1) quarantine workers for 14 days before travel to Alaska (pretravel quarantine), 2) quarantine workers in an Alaskan community with a general acute care or critical access hospital (midtravel quarantine), or 3) quarantine workers at the destination community after arrival (posttravel quarantine) (Table 1).These options also included requirements for safe
MITRAL VALVE MASS WITH LVEF OF LESS THAN 20%: A DIAGNOSTIC AND MANAGEMENT DILEMMA
Authors: Gurjaspreet Bhattal, Jared Christensen, Ammar ELJack, Syed Sarmast, Timothy George, Aasim Afzal, David Rawitscher, Zuyue Wang
Journal: Journal of the American College of Cardiology (2021)
Erratum: Vinorelbine (Navelbine®) in the treatment of non-small-cell lung cancer: Studies with single-agent therapy and in combination with cisplatin (Annals of Oncology (1999) 10:5 (S41-S45))
Authors: R. Gralla, P. Harper, S. Johnson, F. M. Delgado
Journal: Annals of Oncology (1999)
Biofabrication of natural hydrogels for cardiac, neural, and bone Tissue engineering Applications
Authors: Kamil Elkhoury, Margaretha Morsink, Laura Sanchez-Gonzalez, Cyril Kahn, Ali Tamayol, Elmira Arab-Tehrany
Journal: Bioactive Materials (2021)

Natural hydrogels are one of the most promising biomaterials for tissue engineering applications, due to their biocompatibility, biodegradability, and extracellular matrix mimicking ability. To surpass the limitations of conventional fabrication techniques and to recapitulate the complex architecture of native tissue structure, natural hydrogels are being constructed using novel biofabrication strategies, such as textile techniques and three-dimensional bioprinting. These innovative techniques play an enormous role in the development of advanced scaffolds for various tissue engineering applications. The progress, advantages, and shortcomings of the emerging biofabrication techniques are highlighted in this review. Additionally, the novel applications of biofabricated natural hydrogels in cardiac, neural, and bone tissue engineering are discussed as well.
ACCELERATED STENOTIC FLOW BY ENHANCED TRANSTHORACIC DOPPLER ECHOCARDIOGRAPHY IS SUPERIOR TO THE ASCVD RISK SCORE IN PREDICTING OBSTRUCTIVE CORONARY ATHEROSCLEROSIS IN PATIENTS WITH ATYPICAL ANGINA
Authors: Carlo Caiati, Paola Siena, Mara Piccolo, Paolo Pollice, Fortunato Iacovelli, Stefano Favale, Mario Erminio Lepera
Journal: Journal of the American College of Cardiology (2021)
DAYS AT HOME AFTER TRANSCATHETER VERSUS SURGICAL AORTIC VALVE REPLACEMENT IN INTERMEDIATE-RISK PATIENTS
Authors: Mabel Chung, Kamil Faridi, Dhruv Kazi, Laura Burke, Rishi Wadhera, Neel Butala, Zaid Almarzooq, Dingning Liu, Yang Song, Suzanne Baron, Changyu Shen, Robert Yeh
Journal: Journal of the American College of Cardiology (2021)
Heart failure with preserved ejection fraction according to the <scp>HFA‐PEFF</scp> score in <scp>COVID</scp>‐19 patients: clinical correlates and echocardiographic findings
Authors: Sara Hadzibegovic, Alessia Lena, Timothy W. Churchill, Jennifer E. Ho, Sophia Potthoff, Corinna Denecke, Lukas Rösnick, Katrin Moira Heim, Malte Kleinschmidt, Leif Erik Sander, Martin Witzenrath, Norbert Suttorp, Alexander Krannich, Jan Porthun, Tim Friede, Javed Butler, Ursula Wilkenshoff, Burkert Pieske, Ulf Landmesser, Stefan D. Anker, Gregory D. Lewis, Carsten Tschöpe, Markus S. Anker
Journal: European Journal of Heart Failure (2021)

Viral-induced cardiac inflammation can induce heart failure with preserved ejection fraction (HFpEF)-like syndromes. COVID-19 can lead to myocardial damage and vascular injury. We hypothesised that COVID-19 patients frequently develop a HFpEF-like syndrome, and designed this study to explore this.Cardiac function was assessed in 64 consecutive, hospitalized, and clinically stable COVID-19 patients from April-November 2020 with left ventricular ejection fraction (LVEF) ≥50% (age 56 ± 19 years, females: 31%, severe COVID-19 disease: 69%). To investigate likelihood of HFpEF presence, we used the HFA-PEFF score. A low (0-1 points), intermediate (2-4 points), and high (5-6 points) HFA-PEFF score was observed in 42%, 33%, and 25% of patients, respectively. In comparison, 64 subjects of similar age, sex, and comorbidity status without COVID-19 showed these scores in 30%, 66%, and 4%, respectively (between groups: P = 0.0002). High HFA-PEFF scores were more frequent in COVID-19 patients than controls (25% vs. 4%, P = 0.001). In COVID-19 patients, the HFA-PEFF score significantly correlated with age, estimated glomerular filtration rate, high-sensitivity troponin T (hsTnT), haemoglobin, QTc interval, LVEF, mitral E/A ratio, and H2 FPEF score (all P < 0.05). In multivariate, ordinal regression analyses, higher age and hsTnT were significant predictors of increased HFA-PEFF scores. Patients with myocardial injury (hsTnT ≥14 ng/L: 31%) vs. patients without myocardial injury, showed higher HFA-PEFF scores [median 5 (interquartile range 3-6) vs. 1 (0-3), P < 0.001] and more often showed left ventricular diastolic dysfunction (75% vs. 27%, P < 0.001).Hospitalized COVID-19 patients frequently show high likelihood of presence of HFpEF that is associated with cardiac structural and functional alterations, and myocardial injury. Detailed cardiac assessments including echocardiographic determination of left ventricular diastolic function and biomarkers should become routine in the care of hospitalized COVID-19 patients.
IS TRANSESOPHAGEAL ECHOCARDIOGRAPHIC EVALUATION PRIOR TO ELECTROPHYSIOLOGY PROCEDURE NECESSARY IN ANTICOAGULATED PATIENTS WITH MINIMAL INTERRUPTION OF ANTICOAGULATION
Authors: Hassan Alfraidi, Noreen Kelly, Yasufumi Nagata, Joseph Locascio, Shreya Shrestha, Danita Sanborn, Michael Picard
Journal: Journal of the American College of Cardiology (2021)
A CASE OF SEVERE DVT WITH PHLEGMASIA CERULEA DOLENS (PCD) AND MAY-THURNER SYNDROME (MTS) TREATED WITH ENDOVASCULAR INTERVENTION
Authors: Sajjad Haider, Sameer Saleem, Aniruddha Singh, Muhammad Akbar, Avnish Tripathi
Journal: Journal of the American College of Cardiology (2021)