tbuckley/cabot-search huggingface dataset:
Results of percutaneous transluminal coronary angioplasty in women. 1985-1986 National Heart, Lung, and Blood Institute's Coronary Angioplasty Registry.
Authors: S FKelsey, MJames, A LHolubkov, RHolubkov, M JCowley, K MDetre
Journal: Circulation (1993)

BACKGROUNDThe National Heart, Lung, and Blood Institute (NHLBI) Percutaneous Transluminal Coronary Angioplasty (PTCA) 1978-1981 Registry cohort indicated that PTCA risk was higher and efficacy was lower in women. Data from the 1985-1986 PTCA Registry are used to address the question of whether compared with men, women still have a worse outcome after PTCA.METHODS AND RESULTSThe 1985-1986 NHLBI PTCA Registry collected data on consecutive, first-PTCA cases at 16 centers. Initial results are reported for 2,136 patients, 546 of whom were women. Four-year follow-up status was available on 95% of the cohort. Although women were an average of 4.5 years older than the male patients and had more cardiovascular risk factors and more severe angina, their coronary artery disease as assessed by angiography was not more extensive. Rates of angiographic success on a per-lesion basis were similar for women and men (89% versus 88%), and the clinical success rates (79%) were the same. Women had more initial complications (...
Preconditioning does not attenuate myocardial stunning.
Authors: MOvize, KPrzyklenk, S LHale, R AKloner
Journal: Circulation (1992)

BACKGROUNDDespite numerous reports that one or more episodes of brief coronary artery occlusion preconditions the myocardium and dramatically reduces myocardial infarct size produced by a subsequent prolonged ischemia, we recently demonstrated that preconditioning does not attenuate contractile dysfunction in the peri-infarct tissue. However, the specific effects of preconditioning on myocardium in which wall motion has not been compromised by the preconditioning regimen per se and is further submitted to a short ischemic insult (that is, not confounded by necrosis) remain unknown.METHODS AND RESULTSWe addressed these issues in the canine model of myocardial stunning. Eighteen anesthetized dogs underwent 15 minutes of coronary occlusion followed by 3 hours of reperfusion. Before the 15-minute coronary occlusion, each dog received one of three treatments: no intervention (control group, n = 6), one episode of 5-minute coronary occlusion/5-minute reperfusion (PC5 group, n = 6), or one episode of 2.5-minute ...
Abstract 11145: Traditional and Novel Risk Factors Can Estimate Five Year Risk of Developing Heart Failure: Results From the Multi-ethnic Study of Atherosclerosis
Authors: Harjit Chahal, David A Bluemke, Robyn McClelland, Kiang Liu, Pelbreton C Balfour, David Herrington, Steven J Shea, Gregory Burke, Wendy Post, PeiBei Shi, Jean Olson, Karol E Watson, Aaron R Folsom, João A Lima
Journal: Circulation (2012)

Introduction: Heart failure (HF) is a leading cause of mortality especially in elderly. Early detection of at risk individuals is important for preventive strategies. Prior risk scores are derived ...
Increased risk of coronary heart disease death in men with low total and low-density lipoprotein cholesterol in the Russian Lipid Research Clinics Prevalence Follow-up Study.
Authors: D BShestov, A DDeev, A NKlimov, C EDavis, H ATyroler
Journal: Circulation (1993)

BACKGROUNDA continuously increasing risk of coronary heart disease with increasing levels of cholesterol has been reported by many observational and experimental studies. However, this type of association has not been observed in studies in the Russian Lipid Research Clinics.METHODS AND RESULTSTwelve-year coronary heart disease mortality among 40- to 59-year-old men was analyzed in the Moscow and St Petersburg examines in the Russian Lipid Research Clinics Program. The baseline survey examined 6431 men fasting and free of prevalent coronary heart disease. Lipids and lipoproteins, blood pressure, body mass, education level, alcohol intake, and smoking history were obtained. Mortality follow-up was based on contacts with participants or their relatives or neighbors. Coronary heart disease mortality was analyzed based on risk factor levels and was further divided into rapid and nonrapid deaths. A J-shaped cholesterol-coronary heart disease risk function was present for both total and low-density lipoprotein ...
The effects of coronary angioplasty and reperfusion on distribution of myocardial flow.
Authors: D WWahr, T APorts, E HBotvinick, MDae, NSchechtmann, JHuberty, R SHattner, J WO'Connell, KTurley
Journal: Circulation (1985)

To assess the effects of angioplasty (PTCA) and intracoronary streptokinase (ICSK) on relative myocardial perfusion, we administered 99mTc-macroaggregated albumin (MAA) to the uninvolved coronary artery before successful PTCA in 33 patients and before successful infusion of ICSK in eight patients and of 111In-MAA into the same vessel after the intervention. In 10 patients who underwent PTCA, MAA was injected into the involved, instrumented coronary artery. Computer-processed images were acquired in registry and compared. Similar scintigraphic studies were performed in six control patients and in 11 in whom planned interventions were not performed or were unsuccessful. Distribution of MAA was also compared with angiographic results and with the distribution of 201Tl on images obtained in patients at rest or on redistribution images obtained before and soon after intervention in 22 patients. In control patients and those studied after aborted or unsuccessful intervention, scintigraphic results showed excell...
Increased 68Ga-FAPI-04 Uptake in Schmorl Node in a Patient With Gastric Cancer
Authors: Rong Lin, Zefang Lin, Jiaying Zhang, Shaobo Yao, Weibing Miao
Journal: Clinical Nuclear Medicine (2021)

Abstract A 78-year-old man with a newly diagnosed gastric adenocarcinoma underwent 18 F-FDG and 68 Ga-FAPI-04 PET/CT before treatment. Both 18 F-FDG and 68 Ga-FAPI-04 PET/CT demonstrated intense radioactivity in the gastric cancer. However, the benign Schmorl node in the inferior endplate of the T5 vertebrae showed increased uptake of 68 Ga-FAPI-04, which was not FDG avid. Two months after radical gastrectomy of the gastric cancer (pT1aN0M0, IA), a follow-up CT showed that the Schmorl node in T5 vertebrae remained unchanged.
Influence of right heart size on outcome in pulmonary atresia with intact ventricular septum.
Authors: T MGiglia, K JJenkins, AMatitiau, V SMandell, S PSanders, J EMayer, J ELock
Journal: Circulation (1993)

BACKGROUNDNeonates with pulmonary atresia and intact ventricular septum (PA-IVS) are frequently born with hypoplastic right heart structures that must grow after right ventricular decompression (RVD) procedures for a complete two-ventricle physiology to be achieved. Previous authors have asserted that neonatal right heart size or morphology will predict right heart growth potential. Since 1983, our bias has favored early RVD regardless of initial right heart size. In 1986, we recognized a subset of patients with coronary artery abnormalities associated with poor outcome after RVD and have defined these patients as having a right ventricular-dependent coronary circulation (RVDCC).METHODS AND RESULTSTo assess the influence of right heart size on outcome independent of the presence of RVDCC, we measured echocardiographic right ventricular (RV) dimensions in 37 neonates with adequate studies presenting between 1983 and 1990. Coronary artery anatomy was adequately assessed by angiography in 36. RV volume and t...
A Colour Atlas of Tropical Medicine and Parasitology
Authors: H A K Rowland
Journal: BMJ (1977)

Diseases due to parasites or which are especially prevalent in tropical areas of the world are dealt with in a systematic fashion in this book, an addition to the "Atlas" series.Thus arthropod-borne infections, helminthic infections mediated by the soil and by snails, infections acquired through the gastrointestinal tract, the respiratory tract, and through the skin and mucous membranes are dealt with separately.There are also sections on nutritional disorders and miscellaneous condi- tions including snake bite, Lassa fever, Marburg disease, and Burkitt's lymphoma.Photographs, x-rays, maps, diagrams, and charts take up more than half of the book, there being 763 in all-a most remarkable collection.The text is kept to a minimum, being just enough to explain the illustrations.The epidemiology, geographical distribution, clinical picture, and diagnostic procedures are all illustrated in a most lucid fashion.At the end of the book there are 15 tables giving information on the organisms, vectors, hosts, reservoirs for a number of infective disorders, the means of differentiating microfilariae, the importance of snails, a classification of the systemic mycoses, and other topics.
Absence of effects of cyclosporine on myocardial lymphocyte subsets in Coxsackievirus B3 myocarditis in the aviremic stage.
Authors: CKishimoto, W HAbelmann
Journal: Circulation Research (1989)

To test the therapeutic efficacy of immunosuppression with cyclosporine upon the aviremic stage of coxsackievirus B3 (CB3) myocarditis, 2-week-old BALB/c mice were inoculated with 3 x 10(2) plaque-forming units of CB3, and the effects of cyclosporine on peripheral, splenic, and myocardial lymphocyte subsets were investigated. Cyclosporine, 25 mg/kg/day, was administered subcutaneously daily on days 10-31 (experiment 1) and days 30-51 (experiment 2). Treated groups were compared with infected controls for each experiment. In experiment 1, the survival rate of the cyclosporine-treated group was low (17/25 vs. 24/25, p less than 0.05). The severity of myocardial lesions and the distribution of lymphocyte subsets in myocardium and spleen on days 15-18 did not differ between treated and control groups; on the other hand, the percentages of peripheral Thy 1.2+ (pan T) and L3T4+ (activated helper T) cells on days 15-18 were decreased in the treated group, and those of B, Lyt 1+ (helper/inducer T), and Lyt 2+ (su...
Drug-induced Hemolytic Anemias.
Authors: J. H. Jandl
Journal: Annals of Internal Medicine (1963)

s1 April 1963Drug-induced Hemolytic Anemias.J. H. Jandl, M.D.J. H. Jandl, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-730_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNumerous chemical compounds, usually drugs, have been observed to cause hemolytic anemias. Two principal mechanisms have been elucidated: (1) an immunological disorder in which the drug behaves as a hapten or the antigen-antibody complexes fortuitously situate on the red cells; (2) a biochemical disorder in which the drug directly alters cellular metabolism. The great majority of the latter processes are caused by aromatic "redox" compounds such as phenylhydrazine, aniline compounds, quinones, and antimalarials. The anemia is characterized by the appearance of methemoglobin and Heinz bodies. The fundamental biochemical injury consists of an oxidative breakdown of cellular components by oxygen, the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Mass. (BS) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1963Volume 58, Issue 4Page: 730-731KeywordsAnemiaAntigensAntimalarialsCellsDrug metabolismDrugsHemolytic anemiaMethemoglobinOxygen Issue Published: 1 April 1963 PDF DownloadLoading ...
The effects of cigarette smoke and nicotine on platelet thrombus formation in stenosed dog coronary arteries: inhibition with phentolamine.
Authors: J DFolts, F CBonebrake
Journal: Circulation (1982)

This study was undertaken to examine in vivo the effects of cigarette smoke on cyclic reductions in coronary flow due to platelet thrombus formation in the stenosed coronary arteries of anesthetized dogs. The circumflex coronary artery of 21 mongrel dogs was stenosed 60 - 80%, with blood flow measured with an electromagnetic flow probe. After the administration of cigarette smoke, plasma epinephrine was elevated nine times the control level (p less than 0.001) and peak mean blood pressure was elevated one and one-half times control (p less than 0.01). The hematocrit increased several percent (p less than 0.01) with cigarette smoke, although blood gases and pH remained unchanged. In all 21 dogs, spontaneous reductions in coronary blood flow were greatly exacerbated in the stenosed circumflex artery as evidenced by the number of flow reductions, the increased size of the reductions and the rate of flow reduction. Nicotine administered intravenously in doses comparable to those achieved through absorption of...
From the authors:
Authors: S. S. Hwang, J-J. Yim
Journal: European Respiratory Journal (2009)

We thank A.K. Khurana and P.R. Mohapatra for their interest in our recent work 1. They raised several important issues regarding the setting, results and analysis of our study.

First, they point out that the proportion of extensively drug-resistant tuberculosis (XDR-TB) patients among multidrug-resistant TB (MDR-TB) patients in our cohort was unexpectedly high (21.3%). As only 5.7% of the 1,407 patients with MDR-TB in another Korean cohort had XDR-TB 2, we understand their curiosity regarding our MDR-TB cohort. As described in our paper, our cohort consisted of MDR-TB patients diagnosed and treated at Seoul …
The independent effects of oxygen radical scavengers on canine infarct size. Reduction by superoxide dismutase but not catalase.
Authors: S WWerns, M JShea, E MDriscoll, CCohen, G DAbrams, BPitt, B RLucchesi
Journal: Circulation Research (1985)

Previous studies demonstrated a significant reduction of ultimate infarct size in the canine heart by the combined administration of superoxide dismutase plus catalase. This study was performed to assess the independent effects of each enzyme on ultimate infarct size due to ischemia/reperfusion. Dogs received 2-hour infusions of superoxide dismutase, catalase, or albumin (controls) via the left atrium beginning 15 minutes before and ending 15 minutes after a 90-minute occlusion of the left circumflex coronary artery. The dogs were killed 6 hours after reperfusion. After histochemical staining, infarct and risk area masses were calculated by gravimetric and planimetric analysis. Infarct size expressed as a percentage of the area at risk was: superoxide dismutase, 19 +/- 5; catalase, 30 +/- 5; and controls, 40 +/- 3. Infarct size in the superoxide dismutase group, but not the catalase group, was significantly less than in controls (P less than 0.05). No significant differences in hemodynamics or area at ris...
The mechanism of coronary collateral vasoconstriction in response to cyclooxygenase blockade.
Authors: J DAltman, R JBache
Journal: Circulation Research (1994)

The present study was performed to examine the mechanism by which cyclooxygenase blockade produces vasoconstriction in well-developed coronary collateral vessels. Eight dogs were studied 4 to 6 months after occlusion of the left anterior descending coronary artery (LAD) had been performed to stimulate collateral vessel growth. At the time of study, the LAD was cannulated at the site of occlusion for measurement of retrograde blood flow as an index of collateral blood flow. Levels of 6-ketoprostaglandin F1 alpha were 32 +/- 13% higher in blood diverted from the collateral-dependent LAD than in aortic blood (P < .05); the increase in this stable product of prostacyclin metabolism indicated production of prostacyclin across the coronary collateral system. Administration of arachidonic acid into the left main coronary artery to reach collateral vessels entering the LAD resulted in a 21 +/- 6% increase in retrograde flow (P < .01), demonstrating cyclooxygenase activity with production of vasodilator prostaglan...
Acetazolamide and Invasive Mechanical Ventilation for Patients With COPD
Authors: Damien Contou, Nicolas de Prost, Armand Mekontso Dessap
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of intravenously infused histamine on canine forelimb transvascular protein efflux following adrenergic receptor blockade.
Authors: G JGrega, D LMarciniak, B SJandhyala, R MRaymond
Journal: Circulation Research (1980)

The intravenous infusion of high doses of histamine (400 micrograms base/min) produced only small increases in weight (approximately equal to +30 g) and lymph total protein concentration (+ 0.9 g/100 ml) in canine forelimbs perfused at constant inflow. The weight gain was associated with profound decreases in aortic pressure (112 to 30 mm Hg) and in forelimb perfusion pressure (105 to 75 mm Hg) and marked increases in forelimb skin small-vein pressure (from 12 to 25 mm Hg). After treatment with phentolamine, the intravenous infusion of these doses of histamine under the same conditions produced marked decreases in forelimb perfusion pressure (120 to 60 mm Hg) and failed to increase forelimb skin small-vein pressure, yet still produced only minimal increases in weight (+ 12 g) and lymph total protein concentration (+ 0.8 g/100 ml). Following treatment with both phentolamine and propranolol, the intravenous infusion of histamine caused very marked increases in forelimb weight (approximately equal to +75 g) ...
Psychoneurotic profiles of smokers and non-smokers.
Authors: A P Haines, J D Imeson, T W Meade
Journal: BMJ (1980)

electrolyte concentrations returned to normal and her diabetes was easily controlled on biphasic insulin (Rapitard) 16 units daily.After recovery the diuretics were stopped but oxprenolol and perhexiline were continued.Her swallowing completely recovered and a barium swallow was normal.The second patient was a 70-year-old woman with maturity-onset diabetes of 14 years' duration treated with diet alone, but she also took bumetanide 1 mg daily for dependent ankle oedema.After a spell of hot weather she had polyuria for two weeks and had been unable to eat any solid food because of increasing dysphagia.She had lost 5 kg over seven days.On admission she was extremely dehydrated although normotensive.Her blood urea concentra- tion was 23 mmol/l (138 mg/100 ml) and her plasma electrolyte concentrations were sodium 139 mmol (mEq)/l, potassium 5-1 mmol (mEq)/l, chloride 90 mmol/l (mEq)jl, bicarbonate 27 mmol (mEq)/l.Her blood glucose con- centration was 56-5 mmol/l (1017 mg/100 ml).The urine contained over
Abstract 15006: Circulating Inactive Matrix Gla-Protein is Associated With High Aldosterone Levels and Arterial Stiffness in Hypertension
Authors: Julio A Chirinos, Izzah Vassim, Swapna Varakantam, Timothy S Phan, Amer Ahmed Syed, Melissa Beraun, Scott R Akers, Alexei Y Bagrov, Wen Wei, Edward G Lakatta, Olga Fedorova
Journal: Circulation (2016)

Background: large artery stiffness leads to systolic hypertension and increases pulsatile arterial load to the left ventricle. Large artery stiffening is partially dependent on vascular calcificati...
Altered ion transport in aortic smooth muscle during deoxycorticosterone acetate hypertension in the rat.
Authors: A WJones, R GHart
Journal: Circulation Research (1975)

Change in aortic water and electrolyte distribution and in ion turnover were studied during the development of deoxycorticosterone acetate (DOCA) hypertension in the rat. Treatment with DOCA plus saline during the prehypertensive phase was associated with increases in 42K turnover (0.0142 +/- 0.0005 vs. 0.0102 +/- 0.0003 min-1), cell water (0.89 +/- 0.03 vs 0.76 +/- 0.02 kg/kg dry weight), and the ratio of weight to length. These parameters were further increased during the development of hypertension. Significant increases were also observed in total K, Ca, and Mg contents and in Na and C1 contents corrected for the extracellular space. The turnover of 36Cl was increased (0.230 +/- 0.006 vs. 0.136 +/- 0.004 min-1) in DOCA hypertensive rats as was the content of slowly exchanging Cl. Removal of extracellular Ca greatly increased the steady-state turnover of 42K. For control rats, a Ca concentration of 0.1 mM reduced the rate of 42K turnover to less than 50% of the Ca-free value (0.063 +/- 0.004 min-1), wh...
Endoscopic Transmural Drainage Of Pancreatic Pseudocysts
Authors: S Bradai, M Mahmoudi, A Khsiba, M Medhioub, A Ben Mohamed, A Nakhli, L Hamzaoui, Mm Azzouz
Journal: Endoscopy (2021)

Aims Pancreatic pseudocysts (PPC) are collections of fluids containing pancreatic juice and can occur as a result of acute pancreatitis or in patients with chronic pancreatitis. They are most often asymptomatic and resolve spontaneously, but in some cases, endoscopic or surgical treatment is indicated. The aim of this work was to identify methods of endoscopic drainage of pancreatic pseudocysts and to evaluate their results.
The Use Of Bowel Preparation to Improve Diagnostic Yield in Small Bowel Capsule Endoscopy. A Prospective Randomised Nested Case Control Study Of Moviprep Versus Dietary Measures
Authors: F O’Hara, S Seminov, D McNamara
Journal: Endoscopy (2021)

Aims During small bowel capsule endoscopy (SBCE) several factors such as air bubbles, food residue and delayed small bowel transit time can influence optimal visualization. ESGE recommends a Polyethylene glycol-based purgative for better visualisation. However, evidence relating to completion rates and diagnostic yield is still inconclusive and the optimal timing for purgative use remains to be established.
Shall The Journal be Removed to Washington?
Authors: H. Isaac Jones
Journal: JAMA (1891)

<h3>To the Editor:</h3> —Allow me, as a member of the American Medical Association since 1877, to enter my protest against the removal ofThe Journalto Washington. I fail to see any good reason for its removal. 118 Grant Ave., San Francisco, Cal., March 7, 1891.