tbuckley/cabot-search huggingface dataset:
Percutaneous coronary excimer laser angioplasty in patients with stable and unstable angina pectoris. Acute results and incidence of restenosis during 6-month follow-up.
Authors: K RKarsch, K KHaase, WVoelker, ABaumbach, MMauser, LSeipel
Journal: Circulation (1990)

A clinical study was conducted to evaluate the efficacy and safety of percutaneous coronary excimer laser angioplasty in 60 patients with coronary artery disease. Forty-nine patients had stable exertional angina, and 11 patients had unstable angina despite medical therapy. A novel 1.4-mm diameter catheter with 20 quartz fibers of 100-microns diameter each arranged concentrically around a central lumen suitable for a 0.014-in. flexible guide wire was coupled to an excimer laser. A commercial excimer laser emitting energy at a wavelength of 308 nm with a pulse duration of 60 nsec was used. The laser was operated at 20 Hz. Mean energy transmission was 30 +/- 5 mJ/mm2. In five of the 60 patients, laser angioplasty was not attempted. In 23 patients with laser ablation alone, percent stenosis decreased from 76 +/- 14% before to 27 +/- 17% after ablation and was 34 +/- 15% at the early follow-up angiogram. In 32 patients, additional balloon angioplasty was performed because of vessel closure after laser ablation...
Effect of salt depletion and propranolol on blood pressure and plasma renin activity in various forms of hypertension.
Authors: G GGeyskes, PBoer, JVos, F HLeenen, E JMees
Journal: Circulation Research (1975)

The effect of propranolol therapy on the mean arterial pressure (MAP) and plasma renin activity (PRA) was studied in three groups of hypertensive patients who were also treated with saliuretics. Group A: In 14 patients with essential hypertension on chlorthalidone treatment, an additional daily dose of 640 mg propranolol for two months led to a significant reduction of the MAP (from 124 to 105 mm Hg) and PRA (from 5.3 to 2.0 ng AI/ml/hr standing). There was no correlation between MAP reduction and either the original levels or change in PRA. Group B: In 14 patients with essential hypertension and 5 with renal artery stenosis studied on a fixed salt intake, the plasma and extracellular volumes, PRA, and blood pressures were recorded before and after three days of diuretic induced salt depletion and, with maintenance of the depleted state, after three days of propranolol. Salt depletion resulted in a decrease in MAP from 132 to 128 mm Hg (NS), and PRA increased from 3.4 to 22.3 ng AI/ml/hr (P less than 0.01...
Echocardiography of the intra-atrial baffle in dextro-transposition of the great vessels.
Authors: N DNanda, SStewart, RGramiak, J AManning
Journal: Circulation (1975)

Twelve patients with dextro-transposition of the great vessels (age eight months to four years) were studied by echocardiography following Mustard's procedure. Nine of them had also been studied preoperatively. Postoperatively all patients demonstrated structural echoes in the atrial cavity behind the pulmonary root. In ten, the motion pattern generally resembled that of a stenotic atrioventricular valve iwth a sharp anterior movement followed by flattening in diastole and rapid posterior excursion in systole. The maximum amplitude of motion ranged from 4 to 9 mm (average 6.6 mm). In the remaining two cases, the anterior diastolic movement was attenuated. Similar moving, linear echoes with larger amplitudes of motion (10-14 mm) were observed behind the tricuspid valve in four patients while poorly moving, multiple or thick conglomerate echoes (2-11 mm wide) were detected in seven cases. Echocardiographic contrast studies performed by injecting indocyanine green via catheters placed on either side of the i...
Tetralogy of Fallot with pulmonary atresia. Rehabilitation of diminutive pulmonary arteries.
Authors: J JRome, J EMayer, A RCastaneda, J ELock
Journal: Circulation (1993)

BACKGROUNDPatients with tetralogy of Fallot, pulmonary atresia, and diminutive pulmonary arteries are a high-risk group for whom there is no consensus on the correct approach to medical management. The purpose of this report is to review a 14-year experience in the treatment of these patients comparing management schemes.METHODS AND RESULTSBetween January 1978 and August 1988, 91 patients with tetralogy of Fallot and pulmonary atresia had an adequate evaluation of their pulmonary artery anatomy before any surgical management. Forty-eight of these patients had diminutive pulmonary arteries (38 to 104 mm2/m2) supplied by aortopulmonary collaterals and were managed in four different fashions. Of the 9 patients repaired primarily, 7 died early and the two survivors had poor hemodynamic outcome. Of the 9 patients conservatively managed with no intervention before 5 years of age, 4 died and only 1 had a satisfactory hemodynamic result after repair. Of 10 shunted patients, 3 died and 3 had satisfactory repairs. ...
Mechanical properties of human pericardium. Differences in viscoelastic response when compared with canine pericardium.
Authors: J MLee, D RBoughner
Journal: Circulation Research (1985)

Whereas most experiments on the mechanical function of the pericardium have been performed on dogs, very little is known about the applicability of those data to humans. To examine the tensile viscoelastic properties of fresh human pericardium, we have used the methods from our previous study of canine pericardium. Although the mechanical responses of canine and human pericardium were qualitatively similar, human pericardium displayed a significantly greater viscous character. Human pericardium was 7.3 times thicker than canine pericardium, but was more extensible in stress-strain tests, with lower stiffness at a given strain. The static (elastic) stiffness of human pericardium seems identical to that of canine pericardium; lower stiffness per unit thickness of the human tissue at predicted physiological stresses was almost exactly compensated by the greater wall thickness. This effect was also seen in data on fracture strength and stiffness. However, human pericardium displayed greater viscous responses ...
Cross-sectional echocardiography. I. Analysis of mathematic models for quantifying mass of the left ventricle in dogs.
Authors: H LWyatt, M KHeng, SMeerbaum, J DHestenes, J MCobo, R MDavidson, ECorday
Journal: Circulation (1979)

Cross-sectional echocardiography was used to quantify left ventricular mass noninvasively in 21 dogs. Short- and long-axis cross-sectional images of the left ventricle were reproducibly traced at endocardial and epicardial borders during stop-motion video-tape replay. We used area, length and diameter measurements to calculate left ventricular mass by seven mathematic models, including the standard formulas used with M-mode echocardiography and cineangiography. Calculated mass was compared with excised weight of the left ventricle by regression and percent error analyses. Formulas using short-axis areas and long-axis length resulted in higher correlation coefficients (0.94--0.95) and lower mean errors (6--7%) than for standard formulas. Since short-axis areas account for regional left ventricular irregularities, noninvasive quantification of left ventricular mass by cross-sectional echocardiography in dogs is most accurate with formulas using short-axis areas.
Noninvasive assessment of atrioventricular pressure half-time by Doppler ultrasound.
Authors: LHatle, BAngelsen, ATromsdal
Journal: Circulation (1979)

The mean pressure drop across the mitral valve and atrioventricular pressure half-time were measured noninvasively by Doppler ultrasound in 40 normal subjects, in 17 patients with mitral regurgitation, 32 patients with mitral stenosis and 12 with combined stenosis and regurgitation. In normal subjects pressure half-times were 20--60 msec, in patients with isolated mitral regurgitation 35--80 msec and in patients with mitral stenosis 90--383 msec. There was no significant change in pressure half-time with exercise or on repeat examinations, indicating relative independence of mitral flow. In 25 patients with mitral stenosis and seven with combined stenosis and regurgitation, pressure half-time was related to mitral valve area calculated from catheterization data. Increasing pressure half-times occurred with decreasing mitral valve area, and this relationship was not influenced by additional mitral regurgitation. Noninvasive measurement of pressure half-time together with mean pressure drop was useful for e...
Early onset of pulmonary vascular obstruction in patients with aortopulmonary transposition and intact ventricular septum.
Authors: J BLakier, PStanger, M AHeymann, J IHoffmaN, A MRudolph
Journal: Circulation (1975)

Of 29 patients with aortopulmonary transposition with intact ventricular septum who underwent cardiac catheterization as neonates, five subsequently developed increased pulmonary vascular resistance at an early age (7 months to 2 1 2 years). The resistance was high in two patients (11.0 and 12.9 units (U)/m-2), moderate in one (5.5 U/m-2) and mild in two (3.6 and 4.6 U/m-2). The two patients with the highest resistances died as a result of the pulmonary vascular obstruction and it was probably a contributing factor in the death of a third patient. The finding of pulmonary vascular obstruction at an early age in five of 29 patients with transposition of the great arteries with intact septa is noteworthy. It assumes even greater significance as the measurement methods tend to underestimate pulmonary vascular resistance. The possible errors in assessing pulmnary vascular resistance and factors possibly contributing to early development of pulmonary vascular obstruction are discussed.
60TiP ORIENTAL: An open label, multicenter, phase IIIb study of first-line durvalumab plus platinum-based chemotherapy in Chinese patients with extensive stage small cell lung cancer (ES-SCLC)
Authors: Y. Cheng, J. Wang, S. Cang, L. Cao, E. Chen, X. Dong, Y. Fan, B. Gao, Q. Guo, D. Huang, S. Li, A. Liu, D. Lv, Y. Pan, K. Tang, W. Yao, F. Ye, Y. Yu, A. Zang, M. Gao
Journal: Journal of Thoracic Oncology (2021)
Metabolic recovery of acidotic rabbit cardiac muscle: effects of low pH and oxygen shortage.
Authors: FMast, GElzinga
Journal: Circulation Research (1989)

Heat production during and after contraction of isolated rabbit papillary muscles was measured at 20 degrees C with metal-film thermopiles. Under control conditions (0.2 Hz, pH 7.4) total heat and steady-state force production due to 120 twitches were 1.0 +/- 0.4 J/g and 29.5 +/- 5.1 mN/mm2 (mean +/- SD; n = 5), respectively. Increasing the CO2 of the bicarbonate-buffered superfusate from 5% (pH 7.4) to 24% (pH 6.6) led to a decrease of force and heat production, 54% and 72%, respectively, of the control value. The recovery heat-time constant, reflecting the time course of oxidative phosphorylation, increased from 23.0 +/- 5.1 seconds at pH 7.4 to 69.5 +/- 34.7 seconds at pH 6.6. The ratio of recovery and initial heat equaled 1.06 under both conditions. Enhancing the metabolic rate by increasing the stimulation frequency to 1.0 Hz led, after an initial maximum, to a decline of force and heat presumably as the consequence of shortage of oxygen in the muscle core. The recovery phase in this case was charact...
Influence of electrical axis of stimulation on excitation of cardiac muscle cells.
Authors: LTung, NSliz, M RMulligan
Journal: Circulation Research (1991)

Orthogonal sequential shock can defibrillate the heart with greater efficacy compared with single shock defibrillation. In this study we tested the hypothesis that cardiac cells have a preferred orientation in their response to excitatory extracellular electric fields, so that orthogonal shocks may stimulate distinct populations of cells. A micropaddle electrode system was used to deliver rectangular pulses for extracellular field stimulation of individual heart cells. We found that single frog and guinea pig ventricular myocytes are excitable with rectangular pulse field stimulation over a wide range of pulse durations, ranging from 10 msec to as little as 20 microseconds. The excitation field strength varies inversely with pulse duration as described by the Weiss-Lapicque equation, although the frog myocytes show a significant notch at pulse durations of approximately 1-2 msec, and the guinea pig myocytes are more excitable than predicted for pulse durations of less than 0.2 msec. Every myocyte tested...
Endoscopic Band Ligation Versus Argon Plasma Coagulation in the Treatment of Gastric Antral Vascular Ectasia: a Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: BS Hirsch, IB Ribeiro, MP Funari, DTH de Moura, SE Matuguma, S Sanchez-Luna, GdO Luz, FC Mancini, GHP de Oliveira, WM Bernardo, EGH de Moura
Journal: Endoscopy (2021)

Aims Gastric antral vascular ectasia (GAVE) is a condition that frequently carries high morbidity and financial impact. Patients with GAVE typically present occult or overt gastrointestinal bleeding and often become dependent on blood transfusions. Argon plasma coagulation (APC) is the most commonly used endoscopic treatment for this condition, despite considerable recurrence rates. Endoscopic band ligation (EBL) has emerged as an alternative therapy. Our goal was to evaluate the feasibility, efficacy, and safety of APC and EBL for the treatment of GAVE. This is the first systematic review and meta-analysis including only randomized controlled trials (RCT) of this topic.
Principles of Surgery
Authors: David C. Sabiston
Journal: JAMA (1970)

This new surgical text, a collective effort by multiple authors, represents a remarkable achievement. As the book is reviewed, it is apparent that the extensive investigative and clinical experience of the editor-and-chief, Dr. Seymour I. Schwartz, is a strong and consistent influence throughout. Moreover, an unusually able editorial board has been selected with acknowledged depth in all areas of surgery. One of the strongest features of this new book is the penetrating presentation of the basic biochemical, physiological, and pathological aspects of the surgical disorders discussed. This is the primary reason that the work can be highly praised. The chapters on the endocrine and metabolic response to injury, fluid and electrolyte therapy, hemostasis, and circulatory shock each form a strong foundation for the subsequent contributions. The bibliography at the end of each chapter has been carefully selected and the most significant references are cited. The chapter on "Transplantation" by Hume
Re: Adjuvant Chemotherapy With Sequential or Concurrent Anthracycline and Docetaxel: Breast International Group 02-98 Randomized Trial
Authors: E. Sari, N. Bulut, K. Altundag
Journal: JNCI Journal of the National Cancer Institute (2008)

We read with great interest the article by Francis et al. ( 1 ) in which they showed that incorporating docetaxel into anthracyclinebased therapy resulted in an improvement in disease-free survival (DFS) in adjuvant treatment of patients with lymph node – positive breast cancer. They also noted that sequential but not concurrent administration of docetaxel appeared to produce better DFS than anthracycline-based chemotherapy. However, patients in the concurrent docetaxel arm received more cyles (nine cyles vs seven cyles) and more athracyclines (cumulative doses of 225 vs 200 mg/m 2 ) than patients in the sequential docetaxel arm. In this study, information about the HER2 status of tumors was also not described. However, a meta-analysis of eight published clinical trials ( 2 ) showed that, among women with HER2-positive breast cancer in the adjuvant setting, anthracycline-based regimens were superior to non – anthracyclinebased regimens in DFS and overall survival. Thus, the HER2 status as well as the administration schedule may contribute to higher DFS observed in the sequential docetaxel arm than in the concurrent docetaxel arm in the Breast International Group 02-98 trial.
線維筋性異形成腎血管性高血圧の治療経験-flow wire,IVUSの有用性
Authors: 杉山博文, 上原明彦, 竹内和彦, 吉原修, 中野友康, 尾関真理子, 早乙女雅夫, 若原伸行, 林秀晴
Journal: Circulation (2003)
Correspondence on ‘Lupus or not? SLE Risk Probability Index (SLERPI): a simple, clinician-friendly machine-learning-based model to assist the diagnosis of systemic lupus erythematosus’
Authors: Ezgi Deniz Batu, Ummusen Kaya Akca, Ozge Basaran, Yelda Bilginer, Seza Ozen
Journal: Annals of the Rheumatic Diseases (2021)

We read the article by Adamichou et al , ‘Lupus or not? SLE Risk Probability Index (SLERPI): a simple, clinician-friendly machine-learning-based model to assist the diagnosis of systemic lupus erythematosus’ with great interest.1 They proposed a machine-learning-based index (Systemic Lupus Erythematosus Risk Probability Index (SLERPI)) with 14 weighted items to predict the diagnosis of SLE. The original model gives SLE risk probabilities as definite SLE (87%–100%), likely SLE (44%–86%), possible/cannot rule out SLE (15%–43%) and unlikely SLE (0%–14%). The authors have also converted their model into a simple scoring system to facilitate its use in daily practice. Using their model on binary (SLE if score >7 and not SLE if ≤7), they reported a sensitivity of 94.2% and a specificity of 94.4% in their cohort. Since the original cohort was based on adult patients, we have tested the performance of the binary …
Input impedance of the pulmonary arterial system in normal man. Effects of respiration and comparison to systemic impedance.
Authors: J PMurgo, NWesterhof
Journal: Circulation Research (1984)

Input impedance of the pulmonary arterial system was determined in 10 subjects undergoing elective cardiac catheterization. No cardiovascular or pulmonary disease was found in these patients. In five of the subjects, systemic arterial impedance was also obtained, so that both systems could be compared. Pulmonary and systemic peripheral resistances were 79 +/- 9 dynes sec/cm5 (mean +/- SEM) and 1016 +/- 50 dynes sec/cm5, respectively. Characteristic impedance of the pulmonary circulation was lower than the characteristic impedance of the systemic circulation: 20 +/- 1 dynes sec/cm5 vs. 47 +/- 9 dynes sec/cm5, respectively. Pulmonary pressure and flow spectra for both systems are also presented. The amplitudes of the harmonics of pressure and flow are smaller for the pulmonary circulation, which is consistent with the lower pressures and more rounded waveforms of the normal pulmonary circulation. In all 10 subjects, input impedance of the pulmonary system was examined during both the inspiratory and expirat...
Pressure-dependent membrane depolarization in cat middle cerebral artery.
Authors: D RHarder
Journal: Circulation Research (1984)

This study was undertaken to examine the effect of increasing transmural pressure on membrane electrical properties of cat middle cerebral arterial muscle. Middle cerebral arteries were removed from the cat brain, cannulated, and prepared so that transmural pressure within a segment could be manipulated. Intracellular membrane potential was recorded with glass microelectrodes at various transmural pressures. There was a positive slope relating changes in intracellular membrane potential as a function of transmural pressure with a correlation coefficient of 0.79. Blockade of nerve excitation with tetrodotoxin and inhibition of alpha-adrenergic receptors with phentolamine not only did not block the pressure-induced depolarization, but increased the slope of the intracellular membrane potential vs. pressure relationship. This slope was increased upon elevation of extracellular calcium concentration from 2.5 to 4.0 mM and was significantly reduced upon reduction of extracellular calcium concentration to 0.5 m...
Blood levels after sublingual nitroglycerin.
Authors: P WArmstrong, J AArmstrong, G SMarks
Journal: Circulation (1979)

Pharmacokinetic analysis of nitroglycerin (GTN) has been hampered by the lack of a sensitive and specific method for measuring GTN in blood. Therefore, we examined the appearance of GTN in blood after administering 0.6 mg sublingually in 10 studies of normal volunteers. We used a gas-liquid chromatographic method with electron-capture detection and isosorbide dinitrate as the internal standard. GTN appeared in blood at 0.5 minutes, reached a peak of 2.3 +/- 0.36 ng/ml at 2 minutes, fell to 50% of peak value at 7.5 minutes and was barely detectable at 20 minutes. These blood levels paralleled the changes in heart rate and systolic blood pressure. These data show rapid appearance and disappearance of GTN from blood after sublingual administration, a large volume of distribution, and a rapid rate of total body clearance that precludes the liver from being the sole elimination site. This method for analysis of GTN and isosorbide dinitrate should be helpful in defining the role of chronic nitrate therapy.
Left ventricular thrombus in anterior acute myocardial infarction after thrombolysis. A GISSI-2 connected study.
Authors: CVecchio, FChiarella, GLupi, PBellotti, SDomenicucci
Journal: Circulation (1991)

BACKGROUNDStreptokinase reduces the incidence of left ventricular thrombosis after acute myocardial infarction. However, it is unknown whether a similar effect can be obtained with different thrombolytic agents and whether subcutaneous calcium heparin can have an additional efficacy.METHODS AND RESULTSTo compare the effects of two different thrombolytic agents combined or not with heparin on the incidence and features of left ventricular thrombi and their related embolic events, we performed a GISSI-2 ancillary echocardiographic study (the first echocardiogram obtained within 48 hours of symptoms onset and the second before hospital discharge) that enrolled 180 consecutive patients (mean age, 63 +/- 11 years, 142 men) with a first anterior acute myocardial infarction. Patients were randomized into four groups of treatment: recombinant tissue-type plasminogen activator (rt-PA) (n = 47), rt-PA plus heparin (n = 45), streptokinase (n = 39), and streptokinase plus heparin (n = 49). Left ventricular thrombosis...
Patterns of endothelial microfilament distribution in the rabbit aorta in situ.
Authors: D WKim, B LLangille, M KWong, A IGotlieb
Journal: Circulation Research (1989)

The available data on F-actin microfilament distribution in vascular endothelial cells in vivo is limited. In this study, the appearance and distribution of endothelial cell microfilaments in the rabbit thoracic aorta, the abdominal aorta and its major arterial branch points, and the aortic bifurcation were examined. Perfusion fixed rabbit aortas were stained in situ for F-actin by infusing rhodamine phalloidin via a peristaltic pump into the aortas at a slow flow rate. This new technique resulted in excellent visualization of branch points and allowed for a precise description of the actin microfilament bundles in endothelial cells along flow dividers. In the thoracic and abdominal aorta, away from branch ostia, actin microfilaments were localized in two regions of the endothelial cells, as a prominent band that completely outlined the cell periphery, and also as short central stress fibers. The central stress fibers were more frequent and prominent in cells of the abdominal aorta. At branch sites and at...
Shall The Journal be Removed to Washington?
Authors: H. C. Fairbank
Journal: JAMA (1891)

<h3>To the Editor:</h3> —As a member of the American Medical Association I wish to record my name "with the crowd" and say: Let the place of publication remain where it is. I think, with Dr. John M. Batten, that it should remain in its<i>native habitat</i>. Flint, Mich., Feb. 20, 1891.