tbuckley/cabot-search huggingface dataset:
New next-generation microwave thermosphere ablation for small hepatocellular carcinoma
Authors: Hideyuki Tamai, Jumpei Okamura
Journal: Clinical and Molecular Hepatology (2021)

In July 2017, the Emprint™ next-generation microwave ablation system using thermosphere technology (Covidien, Boulder, CO, USA) was approved for use in Japan. This system can produce a predictable spherical ablation zone at higher temperatures than radiofrequency ablation (RFA). The aim of the present study was to elucidate whether this new microwave thermosphere ablation (MTA) could safely improve outcome compared to RFA, which is the standard of care for small hepatocellular carcinoma (HCC). This retrospective study analyzed 513 patients with 630 HCCs (≤3 cm) who were performed by percutaneous RFA (174 patients, 214 HCCs) or MTA (339 patients, 416 HCCs) between January 2016 and March 2020. Median ablation time was significantly shorter for MTA (240 seconds) than for RFA (721 seconds; P<0.001). A significant difference in 3-year local tumor progression rate was evident between the RFA group (22%) and MTA group (8%; P<0.001). Multivariable analysis revealed ablation procedure and tumor diameter as independent factors contributing to local tumor progression (MTA; P<0.001; hazard ratio, 0.565; 95% confidence interval, 0.437-0.731). In patients with primary HCC, a significant difference in overall survival was evident (RFA vs. MTA, 3-year, 77% vs. 95%, P=0.029). Ablation procedure and Child-Pugh score were independent factors contributing to survival. The total complication rate was significantly lower for MTA (8%) than for RFA (14%, P<0.05), particularly for bile duct injury (3% vs. 9%, respectively; P<0.05). Next-generation MTA for small HCC could provide safer, more curative treatment in a shorter ablation time than RFA.
25777 Trends in telemedicine utilization and access for dermatologic concerns during the COVID-19 pandemic
Authors: Michelle S. Lee, Lisa N. Guo, Vinod E. Nambudiri
Journal: Journal of the American Academy of Dermatology (2021)

Background: Telemedicine has become a dominant method of providing dermatologic care during the COVID-19 pandemic, including asynchronous store-and-forward encounters and phone visits. We sought to determine how the COVID-19 pandemic affected utilization and access to telemedicine care for dermatologic concerns three months before (December 2019-February 2020) and during the pandemic (March-May 2020). Methods: Data was analyzed from a national claims database with over 280 million patients within the publicly available COVID-19 Research Database. CPT codes for asynchronous and phone visits and ICD-10 codes for 4 broad dermatologic diagnostic categories (dermatitis, acne, papulosquamous diseases, and alopecia) were used to identify monthly visits by diagnosis, age, and patient race/ethnicity. Results: From March to May 2020 compared with prepandemic, total visits for dermatologic concerns decreased by 27.2%, asynchronous visits increased 990.52%, and phone visits increased 2024.72%. Visits for dermatitis comprised 65.14% of prepandemic visits vs 70.12% of asynchronous visits during the pandemic. African Americans and Hispanics had the highest proportion of phone visits during the pandemic, and African Americans had the highest proportional increase (3785.28%). The median age was 33 years for asynchronous visits and 50 years for phone visits. Conclusions: Asynchronous and phone visits for dermatologic concerns were rapidly scaled up during the COVID-19 pandemic. During the pandemic, a larger proportion of asynchronous visits were for dermatitis-related diagnoses, suggesting efficacy in asynchronous management for this category. Overall, African American, Hispanic, and elderly patients had the greatest proportion of phone visits, which may represent lesser quality compared with other types of visits.
Reply
Authors: Liana Fraenkel, Joan M. Bathon, Bryant R. England, E. William St.Clair, Elie A. Akl
Journal: Arthritis & Rheumatology (2021)

We thank Dr. Evangelatos for his interest in the guideline and his efforts to provide further clarity to this clinical scenario. During the guideline process, the voting panel thoroughly discussed many of these aspects of hypogammaglobulinemia during rituximab treatment that Dr. Evangelatos has adeptly described.
Designing Relevant Preclinical Rodent Models for Studying Links Between Nutrition, Obesity, Metabolism, and Cancer
Authors: Elaine M. Glenny, Michael F. Coleman, Erin D. Giles, Elizabeth A. Wellberg, Stephen D. Hursting
Journal: Annual Review of Nutrition (2021)

Diet and nutrition are intricately related to cancer prevention, growth, and treatment response. Preclinical rodent models are a cornerstone to biomedical research and remain instrumental in our understanding of the relationship between cancer and diet and in the development of effective therapeutics. However, the success rate of translating promising findings from the bench to the bedside is suboptimal. Well-designed rodent models will be crucial to improving the impact basic science has on clinical treatment options. This review discusses essential experimental factors to consider when designing a preclinical cancer model with an emphasis on incorporatingthese models into studies interrogating diet, nutrition, and metabolism. The aims of this review are to (
Integrated longitudinal immunophenotypic, transcriptional, and repertoire analyses delineate immune responses in patients with COVID-19
Authors: Samuele Notarbartolo, Valeria Ranzani, Alessandra Bandera, Paola Gruarin, Valeria Bevilacqua, Anna Rita Putignano, Andrea Gobbini, Eugenia Galeota, Cristina Manara, Mauro Bombaci, Elisa Pesce, Elena Zagato, Andrea Favalli, Maria Lucia Sarnicola, Serena Curti, Mariacristina Crosti, Martina Martinovic, Tanya Fabbris, Federico Marini, Lorena Donnici, Mariangela Lorenzo, Marilena Mancino, Riccardo Ungaro, Andrea Lombardi, Davide Mangioni, Antonio Muscatello, Stefano Aliberti, Francesco Blasi, Tullia De Feo, Daniele Prati, Lara Manganaro, Francesca Granucci, Antonio Lanzavecchia, Raffaele De Francesco, Andrea Gori, Renata Grifantini, Sergio Abrignani
Journal: Science Immunology (2021)

Characterization of the immune responses to SARS-CoV-2 reveals a CD8 + T cell subset that likely establishes the memory to the virus.
Primary Care Medicine: Office Evaluation and Management of the Adult Patient
Authors: Deborah I. Allen
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice
Authors: Andrea C. Bohrer, Ehydel Castro, Zhidong Hu, Artur T.L. Queiroz, Claire E. Tocheny, Maike Assmann, Shunsuke Sakai, Christine Nelson, Paul J. Baker, Hui Ma, Lin Wang, Wen Zilu, Elsa du Bruyn, Catherine Riou, Keith D. Kauffman, Ian N. Moore, Franca Del Nonno, Linda Petrone, Delia Goletti, Adrian R. Martineau, David M. Lowe, Mark R. Cronan, Robert J. Wilkinson, Clifton E. Barry, Laura E. Via, Daniel L. Barber, Amy D. Klion, Bruno B. Andrade, Yanzheng Song, Ka-Wing Wong, Katrin D. Mayer-Barber
Journal: The Journal of Experimental Medicine (2021)

Host resistance to Mycobacterium tuberculosis (Mtb) infection requires the activities of multiple leukocyte subsets, yet the roles of the different innate effector cells during tuberculosis are incompletely understood. Here we uncover an unexpected association between eosinophils and Mtb infection. In humans, eosinophils are decreased in the blood but enriched in resected human tuberculosis lung lesions and autopsy granulomas. An influx of eosinophils is also evident in infected zebrafish, mice, and nonhuman primate granulomas, where they are functionally activated and degranulate. Importantly, using complementary genetic models of eosinophil deficiency, we demonstrate that in mice, eosinophils are required for optimal pulmonary bacterial control and host survival after Mtb infection. Collectively, our findings uncover an unexpected recruitment of eosinophils to the infected lung tissue and a protective role for these cells in the control of Mtb infection in mice.
Hierarchical Nanostructured Electrospun Membrane with Periosteum‐Mimic Microenvironment for Enhanced Bone Regeneration
Authors: Laijun Liu, Yuna Shang, Chaojing Li, Yongjie Jiao, Yanchen Qiu, Chengyi Wang, Yuge Wu, Qiuyun Zhang, Fujun Wang, Zhimou Yang, Lu Wang
Journal: Advanced Healthcare Materials (2021)

An ideal periosteum substitute should be able to mimic the periosteum microenvironment that continuously provides growth factors, recruits osteoblasts, and subsequent extracellular matrix (ECM) mineralization to accelerate bone regeneration. Here, a calcium-binding peptide-loaded poly(ε-caprolactone) (PCL) electrospun membrane modified by the shish-kebab structure that can mimic the periosteum microenvironment was developed as a bionic periosteum. The calcium-binding peptide formed by the negatively charged heptaglutamate domain (E7) in the E7-BMP-2 with calcium ion in the tricalcium phosphate sol (TCP sol) through electrostatic chelation not only extended the release cycle of E7-BMP-2 but also promoted the biomineralization of the bionic periosteum. Cell experiments showed that the bionic periosteum could significantly improve the osteogenic differentiation of the rat-bone marrow-derived mesenchymal stem cells (rBMSCs) through both chemical composition and physical structure. The in vivo evaluation of the bionic periosteum confirmed the inherent osteogenesis of this periosteum microenvironment, which could promote the regeneration of vascularized bone tissue. Therefore, the hierarchical nanostructured electrospun membrane with periosteum-mimic microenvironment is a promising periosteum substitute for the treatment of bone defects.
Abstract 17159: Two Birds One Stone: Salvianolic Acid B Inhibits Coagulation And Platelet Aggregation
Authors: Miguel Neves, Yiming Wang, Tiffany Ni, Xi Lei, Tyler W Stratton, Si-yang Yu, Reid C Gallant, Dan Zhang, Xiaohong Xu, Guangheng Zhu, Yiping Wang, Lijiang Xuan, Jian Ding, Philip E Johnson, Heyu Ni
Journal: Circulation (2019)

Introduction: Danshen (Salvia miltiorrhiza root extracts) have been reported for centuries to control cardiovascular diseases in Chinese medicine. Danshen depside salts are currently approved in Ch...
Abstract 16462: Optical Molecular Imaging of Atheroma Inflammation With a Novel, Mannose Receptor Targeting Near-Infrared Fluorescence Probe in Genetically Engineered Mice and Atheromatous Rabbits
Authors: Kyeongsoon Park, Hyunjin Chung, Ji Bak Kim, Jun Woo Song, Sunki Lee, Dong Joo Oh, Hongki Yoo, Jin Won Kim
Journal: Circulation (2013)

Background: Macrophage-rich atheroma is associated with the evolution and destabilization of plaques. In this study, we newly developed a near-infrared fluorescence (NIRF) optical molecular imaging...
Abstract 12104: High Prevalence of Modified Task Force Criteria for Arrhythmogenic Right Ventricular Cardiomyopathy in Healthy Male Elite Athletes
Authors: Abbas Zaidi, Nabeel Sheikh, Saqib Ghani, Sabiha Gati, Rebecca Howes, Rajan Sharma, Sanjay Sharma
Journal: Circulation (2011)

Purpose: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is the cause of sudden death in a significant proportion of young athletes. Modified Task Force Criteria (TFC) for diagnosis of ARVC ...
Adequate Initial Dosage and Tapering Methods of Steroids to Reduce the Total Corticosteroid Dose in Myasthenia Gravis—Reply
Authors: Simone Birnbaum, Raphaël Porcher, Tarek Sharshar
Journal: JAMA Neurology (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Acid-responsive HPMA copolymer-bradykinin conjugate enhances tumor-targeted delivery of nanomedicine
Authors: Enoch Appiah, Hideaki Nakamura, Robert Pola, Eliška Grossmanová, Ondřej Lidický, Akihiko Kuniyasu, Tomáš Etrych, Mamoru Haratake
Journal: Journal of Controlled Release (2021)
Validation of a Novel Multitarget Blood Test Shows High Sensitivity to Detect Early Stage Hepatocellular Carcinoma
Authors: Naga P. Chalasani, Kyle Porter, Abhik Bhattacharya, Adam J. Book, Brenda M. Neis, Kong M. Xiong, Tiruvidaimarudur S. Ramasubramanian, David K. Edwards, Irene Chen, Scott Johnson, Lewis R. Roberts, John B. Kisiel, K. Rajender Reddy, Amit G. Singal, Marilyn C. Olson, Janelle J. Bruinsma
Journal: Clinical Gastroenterology and Hepatology (2021)
A newly characterized malaria antigen on erythrocyte and merozoite surfaces induces parasite inhibitory antibodies
Authors: Ian C. Michelow, Sangshin Park, Shu-Whei Tsai, Bonnie Rayta, Charisse Flerida A. Pasaje, Sara Nelson, Angela M. Early, Anne P. Frosch, George Ayodo, Dipak K. Raj, Christina E. Nixon, Christian P. Nixon, Sunthorn Pond-Tor, Jennifer F. Friedman, Michal Fried, Patrick E. Duffy, Karine G. Le Roch, Jacquin C. Niles, Jonathan D. Kurtis
Journal: The Journal of Experimental Medicine (2021)

We previously identified a Plasmodium falciparum (Pf) protein of unknown function encoded by a single-copy gene, PF3D7_1134300, as a target of antibodies in plasma of Tanzanian children in a whole-proteome differential screen. Here we characterize this protein as a blood-stage antigen that localizes to the surface membranes of both parasitized erythrocytes and merozoites, hence its designation as Pf erythrocyte membrane and merozoite antigen 1 (PfEMMA1). Mouse anti-PfEMMA1 antisera and affinity-purified human anti-PfEMMA1 antibodies inhibited growth of P. falciparum strains by up to 68% in growth inhibition assays. Following challenge with uniformly fatal Plasmodium berghei (Pb) ANKA, up to 40% of mice immunized with recombinant PbEMMA1 self-cured, and median survival of lethally infected mice was up to 2.6-fold longer than controls (21 vs. 8 d, P = 0.005). Furthermore, high levels of naturally acquired human anti-PfEMMA1 antibodies were associated with a 46% decrease in parasitemia over 2.5 yr of follow-up of Tanzanian children. Together, these findings suggest that antibodies to PfEMMA1 mediate protection against malaria.
Aligning Payments, Services, and Quality in Primary Care
Authors: John H. Wasson, Harold C. Sox, Harold D. Miller
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Outcomes Following Regionalization of Gastric Cancer Care in a US Integrated Health Care System
Authors: Swee H. Teh, Stephen Uong, Teresa Y. Lin, Sharon Shiraga, Yan Li, I-Yeh Gong, Lisa J. Herrinton, Robert A. Li
Journal: Journal of Clinical Oncology (2021)

In 2016, Kaiser Permanente Northern California regionalized gastric cancer care, introducing a regional comprehensive multidisciplinary care team, standardizing staging and chemotherapy, and implementing laparoscopic gastrectomy and D2 lymphadenectomy for patients eligible for curative-intent surgery. This study evaluated the effect of regionalization on outcomes.The retrospective cohort study included gastric cancer cases diagnosed from January 2010 to May 2018. Information was obtained from the electronic medical record, cancer registry, state vital statistics, and chart review. Overall survival was compared in patients with all stages of disease, stage I-III disease, and curative-intent gastrectomy patients using annual inception cohorts. For the latter, the surgical approach and surgical outcomes were also compared.Among 1,429 eligible patients with gastric cancer with all stages of disease, one third were treated after regionalization, 650 had stage I-III disease, and 394 underwent curative-intent surgery. Among surgical patients, neoadjuvant chemotherapy utilization increased from 35% to 66% (P < .0001), laparoscopic gastrectomy increased from 18% to 92% (P < .0001), and D2 lymphadenectomy increased from 2% to 80% (P < .0001). Dissection of ≥ 15 lymph nodes increased from 61% to 95% (P < .0001). Surgical complication rates did not appear to increase after regionalization. Length of hospitalization decreased from 7 to 3 days (P < .001). Overall survival at 2 years was as follows: all stages, 32.8% pre and 37.3% post (P = .20); stage I-III cases with or without surgery, 55.6% and 61.1%, respectively (P = .25); and among surgery patients, 72.7% and 85.5%, respectively (P < .03).Regionalization of gastric cancer care within an integrated system allowed comprehensive multidisciplinary care, conversion to laparoscopic gastrectomy and D2 lymphadenectomy, increased overall survival among surgery patients, and no increase in surgical complications.
Drug Delivery: Biodegradability of Micro/Nanomotors: Challenges and Opportunities (Adv. Healthcare Mater. 13/2021)
Authors: Shuanghu Wang, Jia Xu, Quan Zhou, Peiwu Geng, Bo Wang, Yunfang Zhou, Kun Liu, Fei Peng, Yingfeng Tu
Journal: Advanced Healthcare Materials (2021)
An open science pathway for drug marketing authorization—Registered drug approval
Authors: Florian Naudet, Maximilian Siebert, Rémy Boussageon, Ioana A. Cristea, Erick H. Turner
Journal: PLoS Medicine (2021)

ackgroundBefore drug approval, health authorities like the European Medicines Agency (EMA) and the United States Food and Drug Administration (FDA) evaluate findings from the relevant clinical trials to assess the balance between clinical benefit and safety.When requesting marketing authorization for their drug products, pharmaceutical companies are allowed to choose the indication, design the trials, and choose assessments.In the US, pharmaceutical companies and drug manufacturers must submit full trial protocols to the FDA before those trials can begin.In Europe, companies can, at their discretion, obtain prior scientific advice from the EMA.This consultative process between sponsor and regulator is not fit for purpose, as there is, in practice, no clear a priori consensus on the exact criteria that will be applied to adjudicate success.Although the FDA lays out a set of a priori rules, all too often, it later bends those rules post hoc.For instance, for esketamine, for treatment of resistant depression, the FDA decided post hoc that a maintenance trial could substitute for a second positive short-term trial [1].OAU : Pleaseche ther examples include nalmefene for alcohol use disorder (approved by the EMA), which was based on a post hoc subgroup analysis of the pivotal trials [2], or eteplirsen for muscular dystrophy (approved by the FDA) despite a lack of clinical evidence [3].Even the initial standards agreed upon between the sponsor and regulator can be too lax.Too often, trials ask the wrong question: Trials may explore superiority over an inappropriately weak comparator such as placebo when superiority versus an already approved active comparator would be more clinically relevant [4].Trials can also be underpowered [4], focus on surrogate markers, or omit clinically relevant outcomes [5].Moreover, the regulator is laissez-faire with respect to trial publication in journal articles, allowing the sponsor to freely choose which findings to include and how to frame them, often diverging starkly from the
Acute effect of continuous positive airway pressure on nocturnal variation of atrial natriuretic pepticle levels in heart failure patients with obstructive sleep apnea
Authors: Tagawa Y, Yumino D, Kajimoto K, Takeuchi K, Ushikubo E, Imai T, Mizuno M, Takagi A, Matsuda N, Tsurumi Y, Hagiwara N, Kasanuki H
Journal: Journal of the American College of Cardiology (2006)
Beyond performance metrics: modeling outcomes and cost for clinical machine learning
Authors: James A. Diao, Leia Wedlund, Joseph Kvedar
Journal: npj Digital Medicine (2021)

Advances in medical machine learning are expected to help personalize care, improve outcomes, and reduce wasteful spending. In quantifying potential benefits, it is important to account for constraints arising from clinical workflows. Practice variation is known to influence the accuracy and generalizability of predictive models, but its effects on cost-effectiveness and utilization are less well-described. A simulation-based approach by Mišić and colleagues goes beyond simple performance metrics to evaluate how process variables may influence the impact and financial feasibility of clinical prediction algorithms.