tbuckley/cabot-search huggingface dataset:
Therapeutic strategies for severe COVID-19: a position paper from the Italian Society of Infectious and Tropical Diseases (SIMIT)
Authors: Cristina Mussini, Marco Falcone, Silvia Nozza, Caterina Sagnelli, Roberto Parrella, Marianna Meschiari, Nicola Petrosillo, Claudio Mastroianni, Antonio Cascio, Chiara Iaria, Massimo Galli, Antonio Chirianni, Evangelista Sagnelli, Carmelo Iacobello, Giovanni Di Perri, Francesco Mazzotta, Giampiero Carosi, Marco Tinelli, Paolo Grossi, Orlando Armignacco, Vincenzo Portelli, Massimo Andreoni, Marcello Tavio
Journal: Clinical Microbiology and Infection (2021)
Response to Open Peer Commentaries for “There’s No Harm in Talking: Reestablishing the Relationship Between Theological and Secular Bioethics”
Authors: Michael McCarthy, Mary Homan, Michael Rozier
Journal: The American Journal of Bioethics (2020)

This article refers to:There’s No Harm in Talking: Re-Establishing the Relationship Between Theological and Secular BioethicsPurely Faith-Based vs. Rationally-Informed Theological BioethicsPluralism in the Jewish Ethical TraditionThe Devil in the DetailsVulnerable Life: Reflections on the Relationship Between Theological and Philosophical Ethics“‘There’s No Harm in Talking’…True…But It Depends on How We Talk and What We Then Do”Community, Complicity, and Critique: Christian Concepts in Secular BioethicsMethodological Clarity in Religious Perspectives of Bioethical Issues: Lessons from Islamic StudiesWhat’s Missing in Secular Bioethics? The False Dichotomy between “the Secular” and “the Theological”Talking Can Be Harmful Depending on What You SayTalking at Cross Purposes: Why We Shouldn’t Re-Establish the Relationship Between Theological and Secular BioethicsTheorizing Religion in Its Meanings for BioethicsCorrelating Bioethics and TheologyA Pandemic Refocuses Bioethics on “The Big Questions”
<i>HLA–B*08</i> Identified as the Most Prominently Associated Major Histocompatibility Complex Locus for Anti–Carbamylated Protein Antibody–Positive/Anti–Cyclic Citrullinated Peptide–Negative Rheumatoid Arthritis
Authors: Cristina Regueiro, Desire Casares‐Marfil, Karin Lundberg, Rachel Knevel, Marialbert Acosta‐Herrera, Luis Rodriguez‐Rodriguez, Raquel Lopez‐Mejias, Eva Perez‐Pampin, Ana Triguero‐Martinez, Laura Nuño, Ivan Ferraz‐Amaro, Javier Rodriguez‐Carrio, Rosario Lopez‐Pedrera, Montse Robustillo‐Villarino, Santos Castañeda, Sara Remuzgo‐Martinez, Mercedes Alperi, Juan J. Alegre‐Sancho, Alejandro Balsa, Isidoro Gonzalez‐Alvaro, Antonio Mera, Benjamin Fernandez‐Gutierrez, Miguel A. Gonzalez‐Gay, Leendert A. Trouw, Caroline Grönwall, Leonid Padyukov, Javier Martin, Antonio Gonzalez
Journal: Arthritis & Rheumatology (2020)

Previously, only the HLA-DRB1 alleles have been assessed in rheumatoid arthritis (RA). The aim of the present study was to identify the key major histocompatibility complex (MHC) susceptibility factors showing a significant association with anti-carbamylated protein antibody-positive (anti-CarP+) RA.Analyses were restricted to RA patients who were anti-cyclic citrullinated peptide antibody negative (anti-CCP-), because the anti-CCP status dominated the results otherwise. Therefore, we studied samples from 1,821 anti-CCP- RA patients and 6,821 population controls from Spain, Sweden, and the Netherlands. The genotypes for ~8,000 MHC biallelic variants were assessed by dense genotyping and imputation. Their association with the anti-CarP status in RA patients was tested with logistic regression and combined with inverse-variance meta-analysis. Significance of the associations was assessed according to a study-specific threshold of P < 2.0 × 10-5 .The HLA-B*08 allele and its correlated amino acid variant Asp-9 showed a significant association with anti-CarP+/anti-CCP- RA (P < 3.78 × 10-7 ; I2 = 0). This association was specific when assessed relative to 3 comparator groups: population controls, anti-CarP-/anti-CCP- RA patients, and anti-CCP- RA patients who were positive for other anti-citrullinated protein antibodies. Based on these findings, anti-CarP+/anti-CCP- RA patients could be separated from other antibody-defined subsets of RA patients in whom an association with the HLA-B*08 allele has been previously demonstrated. No other MHC variant remained associated with anti-CarP+/anti-CCP- RA after accounting for the presence of the HLA-B*08 allele. Specifically, the reported association of HLA-DRB1*03 was observed at a level comparable to that reported previously, but it was attributable to linkage disequilibrium.These results identify HLA-B*08 carrying Asp-9 as the MHC locus showing the strongest association with anti-CarP+/anti-CCP- RA. This knowledge may help clarify the role of the HLA in susceptibility to specific subsets of RA, by shaping the spectrum of RA autoantibodies.
Cross-Training in Neurology and Psychiatry—Reply
Authors: Matcheri S. Keshavan, Bruce H. Price, Joseph B. Martin
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Spine system changes in soldiers after load carriage training in a plateau environment: a prediction model research
Authors: Hao Qu, Ling-Jia Yu, Ju-Tai Wu, Gang Liu, Sheng-Hui Liu, Peng Teng, Li Ding, Yu Zhao
Journal: Military Medical Research (2020)

Low back pain is the most common spinal disorder among soldiers, and load carriage training (LCT) is considered the main cause. We aimed to investigate changes in the spine system of soldiers after LCT at high altitudes and the change trend of the lumbar spine and surrounding soft tissues under different load conditions. Magnetic resonance imaging scans of the lumbar spines of nine soldiers from plateau troops were collected and processed. We used ImageJ and Surgimap software to analyze changes in the lumbar paraspinal muscles, intervertebral discs (IVDs), intervertebral foramina, and curvature. Furthermore, the multiple linear regression equation for spine injury owing to LCT at high altitudes was established as the mathematical prediction model using SPSS Statistics version 23.0 software. In the paraspinal muscles, the cross-sectional area (CSA) increased significantly from 9126.4 ± 691.6 mm2 to 9862.7 ± 456.4 mm2, and the functional CSA (FCSA) increased significantly from 8089.6 ± 707.7 mm2 to 8747.9 ± 426.2 mm2 after LCT (P < 0.05); however, the FCSA/CSA was not significantly different. Regarding IVD, the total lumbar spine showed a decreasing trend after LCT with a significant difference (P < 0.05). Regarding the lumbar intervertebral foramen, the percentage of the effective intervertebral foraminal area of L3/4 significantly decreased from 91.6 ± 2.0 to 88.1% ± 2.9% (P < 0.05). For curvature, the lumbosacral angle after LCT (32.4° ± 6.8°) was significantly higher (P < 0.05) than that before LCT (26.6° ± 5.3°), while the lumbar lordosis angle increased significantly from 24.0° ± 7.1° to 30.6° ± 7.4° (P < 0.05). The linear regression equation of the change rate, △FCSA% = - 0.718 + 23.085 × load weight, was successfully established as a prediction model of spinal injury after LCT at high altitudes. The spinal system encountered increased muscle volume, muscle congestion, tissue edema, IVD compression, decreased effective intervertebral foramen area, and increased lumbar curvature after LCT, which revealed important pathophysiological mechanisms of lumbar spinal disorders in soldiers following short-term and high-load weight training. The injury prediction model of the spinal system confirmed that a load weight < 60% of soldiers' weight cannot cause acute pathological injury after short-term LCT, providing a reference supporting the formulation of the load weight standard for LCT.
Clopidogrel: Linking Evaluation of Platelet Response Variability to Mechanism of Action⁎⁎Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Authors: Andrew L. Frelinger, Alan D. Michelson
Journal: Journal of the American College of Cardiology (2005)
Danish mask study: comparing apples and oranges
Authors: Jan Karasek
Journal: BMJ (2020)

<h3>Background</h3> IgG-based tests for the diagnosis of active tuberculosis disease (TB) often show a lack of specificity in TB endemic regions, which is mainly due to a high background prevalence of latent TB infection (LTBI). Here, we investigate the combined performance of the responses of different Ig classes to selected mycobacterial antigens in primary healthcare clinic attendees with signs and symptoms suggestive of TB. <h3>Methods</h3> We evaluated the sensitivity and specificity of serologic IgA, IgG and/or IgM to LAM, 7 mycobacterial protein antigens (ESAT-6, Tpx, PstS1, AlaDH, MPT64, 16 kDa and 19 kDa) and 2 antigen combinations (TUB, TB-LTBI) in the plasma of 42 individuals with other respiratory diseases (separated into 21 LTBI controls and 21 uninfected healthy controls), and 21 active TB patients at baseline, of whom 19 were followed up at month 6 at the end of TB treatment. <h3>Results</h3> The leading single serodiagnostic markers were anti-16 kDa IgA, anti-MPT64 IgA, anti-LAM IgG and anti-TB-LTBI IgG. IgA responses to MPT64 and 16 kDa had the highest sensitivity/specificity of 95%/95% and 95%/90% in differentiating active TB from other respiratory diseases and active TB from LTBI controls, respectively. The combined use of 3 or 4 antibodies further improved this performance to accuracies above 95%. After successful completion of anti-TB treatment at month 6, only particularly anti-TUB IgG showed distinctively decreased levels. <h3>Conclusions</h3> These results show the potential of combining IgG and IgA responses against selected protein and non-protein antigens in differentiating active TB from other respiratory diseases in TB endemic settings, and may provide a benchmark for vaccines.
Helen Salisbury: Bumps in the road to covid vaccine rollout
Authors: Helen Salisbury
Journal: BMJ (2020)

General practices are mostly small businesses with a single (very complicated) NHS contract, and there’s much variation in how business-like they are. When doctors choose where to work, they need to know where a practice sits on the business-service spectrum if they’re going to feel comfortable with their colleagues.

A practice that’s entirely service oriented, responding to demand for appointments by increasing capacity with no limits, will soon find itself unable to pay the bills or with staff burning out from overwork—or both. If a practice focuses purely on the bottom line, attention may be paid to the most financially rewarding …
Abstract 16802: Intermittent Pneumatic Compression for Peripheral Artery Disease and End Stage Renal Disease to Improve Quality of Life and Functional Limitations
Authors: Luis H Paz Rios, Christian Torres, Juan Del Cid Fratti, Muhammad T Ayub, Harry E Fuentes, Ahmed Al-Ogaili, Jose Sleiman, Peter Hart, Alfonso J Tafur
Journal: Circulation (2018)

Background: Peripheral artery disease (PAD) is a prevalent condition affecting one in four patients with end stage renal disease (ESRD). Intermittent pneumatic compression (IPC) has proven benefits in PAD. We are conducting a trial testing the utility of IPC in the ESRD population by assessing the improvement in quality of life (QOL), functional limitation and walking performance from PAD-related symptoms. We aim to present our pilot results. Methods: Prospective single cohort study undergoing recruitment of outpatients at the hemodialysis (HD) unit of John H. Stroger Hospital. The calculated sample size is 78. PAD is confirmed by ankle-brachial index (ABI) and demographics obtained from interview and chart review. At baseline and post intervention, a Six-minute Walk Test (6MWT), Peripheral Artery Questionnaire (PAQ) and Walking Impairment Questionnaire (WIQ) are administered. The IPC device (Bio Arterial Plus) is used for intervention during HD. We present continuous variables as median (IQR) and categorical variables as percentage. Wilcoxon signed rank test was performed for comparison of results. Results: So far, 9 patients have completed intervention for the pilot study, 44% are men, the majority hispanic (66%), with age 48 (41-63) years. At baseline 66% of ABI were abnormal, all due to non-compressible PAD 1.46 (1.20-1.62). All patients have HTN, 44% diabetes, 33% hyperlipidemia and 33% heart failure. The median time of intervention is 70 (60-83) days. There was a significant difference in QOL measured by the WIQ (Fig.1), PAQ physical limitation (p=0.011), and PAQ social limitation (p=0.018). Although there was a trend towards benefit, no statistical difference was found on rest of objective and subjective measured parameters (p&gt;0.05) Conclusions: Preliminary, IPC shows to improve many subsets of QOL in patients with ESRD and PAD. Given the small sample, improvement of walking distance remains elusive but with trends towards benefit.
A Rainy Day
Authors: Vishal I. Patel
Journal: Circulation (2020)

ECG CHALLENGEA 38-year-old male was brought into the emergency department after being found down with minimal clothing near a bike path on a rainy morning.The patient received intravenous dextrose en route for a blood glucose of 21 mg/dL, as well as intravenous naloxone for suspected opiate overdose.On arrival, the patient's initial examination was notable for a Glasgow Coma Scale of 8 (E1, V2, M5), mild combativeness, symmetrical constricted pupils, labored breathing on room air, and the absence of other signs of trauma or injury.The patient was intubated and resuscitated with intravenous fluids.Laboratory studies revealed a mild leukocytosis of 11.4 K/uL, anion gap of 20 mmol/L, and arterial pH of 7.05 with Pco 2 of 71 mm Hg.Lactic acid, troponin, brain natriuretic peptide, and blood glucose were all within normal limits.Diagnostic studies included a computed tomographic scan of the head and cervical spine, as well as a portable chest x-ray, all of which were negative for acute processes.The patient's initial 12-lead ECG is shown in Figure 1.What abnormalities are present, and in what clinical settings are they found?What vitals signs would be expected?Please turn the page to read the diagnosis.
Preventing Disease, Not Sex—Harm Reduction, HIV Preexposure Prophylaxis, and Sexually Transmitted Infections
Authors: Jenell Stewart, Jared M. Baeten
Journal: JAMA Network Open (2020)

Hamish McManus, PhD; Andrew E. Grulich, MBBS, PhD; Janaki Amin, PhD; Christine Selvey, MD; Tobias Vickers, MD; Benjamin Bavinton, PhD; Iryna Zablotska, MD, PhD; Stephanie Vaccher, PhD; Fengyi Jin, PhD; Joanne Holden, MBA; Karen Price, MPH; Barbara Yeung, MPH; Gesalit Cabrera Quichua, BMSc; Erin Ogilvie, MPH; Anna McNulty, MD; David Smith, MD; Rebecca Guy, PhD
Emerging Role of Ubiquitination in the Regulation of PD-1/PD-L1 in Cancer Immunotherapy
Authors: Xiaoli Hu, Jing Wang, Man Chu, Yi Liu, Zhi-wei Wang, Xueqiong Zhu
Journal: Molecular Therapy (2021)

A growing amount of evidence suggests that ubiquitination and deubiquitination of programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) play crucial roles in the regulation of PD-1 and PD-L1 protein stabilization and dynamics. PD-1/PD-L1 is a major coinhibitory checkpoint pathway that modulates immune escape in cancer patients, and its engagement and inhibition has significantly reshaped the landscape of tumor clearance. The abnormal ubiquitination and deubiquitination of PD-1/PD-L1 influence PD-1/PD-L1-mediated immunosuppression. In this review, we describe the ubiquitination- and deubiquitination-mediated modulation of PD-1/PD-L1 signaling through a variety of E3 ligases and deubiquitinating enzymes (DUBs). Moreover, we briefly expound on the anticancer potential of some agents that target related E3 ligases, which further modulate the ubiquitination of PD-1/PD-L1 in cancers. Therefore, this review reveals the development of a highly promising therapeutic approach for cancer immunotherapy by targeting PD-1/PD-L1 ubiquitination.
Establishing the Prognostic Value of Rb-82 PET Myocardial Perfusion Imaging: A Step in the Right Direction⁎⁎Editorials published in JACC: Cardiovascular Imaging reflect the views of the authors and do not necessarily represent the views of JACC: Cardiovascular Imaging or the American College of Cardiology.
Authors: Raymond J. Gibbons, Panithaya Chareonthaitawee
Journal: JACC. Cardiovascular imaging (2009)
Abstract 4562: Comprehensive analysis of the <i>TMPRSS2-ERG</i> translocation during prostate cancer progression
Authors: Christian Ruiz, Martin Braun, Veit J. Scheble, Tobias Zellweger, Cyrill A. Rentsch, Alexander Bachmann, Albert Dodi, Sven Perner, Isabell A. Sesterhenn, Shiv Srivastava, Lukas Bubendorf
Journal: Cancer Research (2012)

Abstract Introduction. Approximately half of the diagnosed prostate carcinomas (PC) are characterized by a chromosomal rearrangement fusing the androgen regulated gene TMPRSS2 to the oncogenic ETS transcription factor ERG. Aim of this study was to comprehensively analyze the impact of this translocation on the expression of the ERG gene in hormone-naïve (untreated) and castration-resistant prostate cancers and to define the influence of AR protein expression and genomic amplification in this context. Methods. We constructed a tissue microarray (TMA) containing 915 tissue cores from 107 hormone-naïve PC and from 101 castration-resistant (CR) PC. In addition, we included 56 specimens from distant metastases. We analyzed the TMPRSS2-ERG translocation status by fluorescence in-situ hybridization and the expression profiles of ERG, AR and the proliferation marker Ki67 by immunohistochemistry. Results. Nearly half of the analyzed PC tissue specimens (untreated: 38%, castration-resistant: 46%) harbored a TMPRSS2-ERG gene fusion. Untreated PC with positive translocation status showed increased tumor cell proliferation (p&amp;lt;0.05). As expected, TMPRSS2-ERG gene fusion was strongly associated with increased ERG protein expression in untreated, as well as in castration-resistant PC (both p&amp;lt;0.0001). However, we detected a subgroup of CR PCs with the gene fusion, but without detectable ERG protein expression. This subgroup showed significantly lower levels of AR protein expression and of the androgen regulated serum PSA (both p&amp;lt;0.05). Conclusions. This comprehensive study comparing the TMPRSS2-ERG gene and ERG protein expression status in a large cohort of hormone-naïve and CR PC, identifies a subgroup of translocated CR PCs without ERG protein expression. Our results suggest that this subgroup may represent CR PCs with a dispensed AR pathway. Further analyses may help to explain if these tumors represent a distinct subgroup of AR independent CR PCs. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4562. doi:1538-7445.AM2012-4562
Obesity and Eating Disorder Disparities Among Sexual and Gender Minority Youth
Authors: Natasha A. Schvey, Arielle T. Pearlman, David A. Klein, Mikela A. Murphy, Joshua C. Gray
Journal: JAMA Pediatrics (2020)

Kilograms Overweight = [BMI -BMI ow ] × Height (in Meters) 2 Pounds Overweight = [BMI -BMI ow ] × Height (in Meters) 2 × 2.205 Kilograms Obese = [BMI -BMI ob ] × Height (in Meters) 2 Pounds Obese = [BMI -BMI ob ] × Height (in Meters) 2 × 2.205where BMI ow indicates the 85th percentile BMI for age and sex and BMI ob indicates the 95th percentile BMI for age and sex.For ease of manual calculations, multiplying by height 2 is equivalent to multiplying by height twice (ie, height × height).To judge measurement validity and clinical validity for use in clinical care, research and surveillance, we first calculated Pearson correlation coefficients between kilograms (or pounds) overweight and kilograms (or pounds) obese and other accepted measures of obesity and weight-associated physiological risk factors at 2 different times, at study entry and approximately 3 years later (Table 1).We then conducted a similar analysis comparing changes in each measure over approximately 1 and 3 years (Table 2).The threshold of statistical significance was set at a 2-tailed P < .05. Analysis was conducted with SAS version 9.4 (SAS Institute) between February 2019 and November 2019.Results | Of the 268 children participating, 147 (54.9%) were girls and 263 (98.1%) were Latino.A total of 202 (75.4%) had BMIs at or above the 95th percentile, 149 (55.6%) at or above the 97th percentile, and 87 (32.4%) at or above 120% of the 95th percentile.Kilograms (or pounds) overweight and kilograms (or pounds) obese were highly correlated with other measures of obesity (baseline r range, 0.92 to 0.98; year 3 r range, 0.97 to 0.99) and comparably with those measures with physiological risk factors (Table 1).All correlations generally increased as children aged 7 to 11 to 10 to 14 years.One-year and 3-year changes in kilograms (or pounds) overweight and kilograms (or pounds) obese correlated highly with concurrent changes in other obesity measures (1-year changes: r range, 0.92 to 0.97; 3-year changes: r range, 0.86 to 0.95) and comparably with those measures with concurrent changes in physiological risk factors (Table 2).Discussion | Kilograms (or pounds) overweight and kilograms (or pounds) obese are simple and valid metrics to express excess weight and weight changes among children with overweight and obesity.This could mean, for example, describing a person as having a weight that is 4.55 kg (or 10 lb) overweight or 4.55 kg (or 10 lb) obese, rather than (or in addition to) having a weight that is 3 BMI units greater than the cutoff for overweight or obesity, being at 180% of the median BMI for age and sex, or being 20% above the 95th percentile BMI for age and sex.This approach may be more meaningful for patients, families, and clinicians who are used to thinking about weight, weight gain, and weight loss in terms of kilograms (or pounds).
Long-term self-renewing stem cells in the adult mouse hippocampus identified by intravital imaging
Authors: Sara Bottes, Baptiste N. Jaeger, Gregor-Alexander Pilz, David J. Jörg, John Darby Cole, Merit Kruse, Lachlan Harris, Vladislav I. Korobeynyk, Izaskun Mallona, Fritjof Helmchen, François Guillemot, Benjamin D. Simons, Sebastian Jessberger
Journal: Nature Neuroscience (2020)
Tumor size-dependent abscopal effect of polydopamine-coated all-in-one nanoparticles for immunochemo-photothermal therapy of early- and late-stage metastatic cancer
Authors: Jingjing Sun, Zhuoya Wan, Jieni Xu, Zhangyi Luo, Pengfei Ren, Bei Zhang, Dingwei Diao, Yixian Huang, Song Li
Journal: Biomaterials (2020)