tbuckley/cabot-search huggingface dataset:
Multiple Myeloma
Authors: D. P. Degenhardt, D. Sheehan
Journal: BMJ (1949)

PROSTATIC OBSTRUCTIONat two-monthly intervals.If residual urine was consider- able or renal impairment evident the cases were observed weekly, and if rapid improvement did not occur a per- urethral resection was carried out.Cases suffering from acute retention were as a rule submitted to perurethral resection after preliminary catheter drainage if necessary, and oestrogen given by the mouth subsequently.If micro- scopical examination revealed an undifferentiated car- cinoma, deep x-ray therapy was often given in addition to synthetic oestrogen by the mouth, as my experience had suggested that this form of cancer was less likely to be kept in check by oestrogen therapy alone.Resalts in a Series of 176 Malignant Cases Admitted to Hospital 145 (82%) submitted to operation: 101 (70%) .. Perurethral resection .. Deaths 3 (2-8%) 30 (20,) 'O Suprapubic prostatectormyDeaths 2 (6-6y.)14 (10%) .. Suprapubic cystostomy 31 (18%') not submitted to operation: 25 (14%. of total) .Dienoestrol alone 7 .. ...Died in hospital Summary A clinical method of diagnosis to prevent cases of prostatic obstruction being missed is described.The treatment of the acute cases and the indications for the various types of operations are discussed.The paper is based upon a series of 2,192 consecutive cases of bladder-neck obstruction due to non-malignant disease of the prostate, of which 1,960 cases were submitted to prostat- ectomy, with a mortality from all causes of 3.01%.The perurethral method was used in 68.73% of cases (74.3% in private cases).The perurethral method is considered the method of choice in the majority of cases.The treatment of cancer of the prostate is discussed.Prostatic obstruction should be relieved as early as possible before secondary changes occur in the renal and cardiovascular systems: too many cases still come for treatment late in the progress of the disease.I wish to thank Sisters Deacon, Meek, and Walker, without whose care, organization, and enthusiasm these results could not have been obtained.My grateful thanks are also due to Mr. Hadda, past registrar, and to Messrs. Breckenridge and Harrison, present registrars, for operating upon many of the cases, and also to Mr.Harrison for compiling the results.Last, but not least, I thank the many house-surgeons who have helped me.
Histopathological Characterization of High-Intensity Signals in Coronary Plaques on Noncontrast T1-Weighted Magnetic Resonance Imaging
Authors: Kenzo Uzu, Rika Kawakami, Takahiro Sawada, Tomofumi Takaya, Yasuyo Taniguchi, Seiichi Hirota, Kenichi Fujii, Yoshinori Yasaka, Hiroya Kawai
Journal: JACC. Cardiovascular imaging (2020)
12893 M89, a combination of 89% Vichy mineralizing water and hyaluronic acid reinforces the skin barrier and shows efficacy and high tolerability in various facial inflammatory dermatoses and esthetic procedures as adjunct
Authors: Jerry Tan, Julieta Spada, Cecilia Orlandi, Martina Kerscher, Maryna Anfilova, Sonya Abdulla, Klaudia Preisz, Delphine Kerob, Elena Araviiskaia
Journal: Journal of the American Academy of Dermatology (2020)
Combination of metabolic intervention and T cell therapy enhances solid tumor immunotherapy
Authors: Meixi Hao, Siyuan Hou, Weishuo Li, Kaiming Li, Lingjing Xue, Qifan Hu, Lulu Zhu, Yue Chen, Hongbin Sun, Caoyun Ju, Can Zhang
Journal: Science Translational Medicine (2020)

A combination of metabolic reprogramming and T cell therapy via surface anchor-engineering results in improved efficacy of immunotherapy in solid tumors.
A Tumor Suppressor Enhancer of<i>PTEN</i>in T-cell Development and Leukemia
Authors: Luca Tottone, Olga Lancho, Jui-Wan Loh, Amartya Singh, Shunsuke Kimura, Juliette Roels, Anna Kuchmiy, Steven Strubbe, Matthew A. Lawlor, Victoria da Silva-Diz, Shirley Luo, Stéphanie Gachet, Carlos A. García-Prieto, Rico Hagelaar, Manel Esteller, Jules P.P. Meijerink, Jean Soulier, Tom Taghon, Pieter Van Vlierberghe, Charles G. Mullighan, Hossein Khiabanian, Pedro P. Rocha, Daniel Herranz
Journal: Blood Cancer Discovery (2020)

Long-range oncogenic enhancers play an important role in cancer. Yet, whether similar regulation of tumor suppressor genes is relevant remains unclear. Loss of expression of PTEN is associated with the pathogenesis of various cancers, including T-cell leukemia (T-ALL). Here, we identify a highly conserved distal enhancer (PE) that interacts with the PTEN promoter in multiple hematopoietic populations, including T-cells, and acts as a hub of relevant transcription factors in T-ALL. Consistently, loss of PE leads to reduced PTEN levels in T-ALL cells. Moreover, PE-null mice show reduced Pten levels in thymocytes and accelerated development of NOTCH1-induced T-ALL. Furthermore, secondary loss of PE in established leukemias leads to accelerated progression and a gene expression signature driven by Pten loss. Finally, we uncovered recurrent deletions encompassing PE in T-ALL, which are associated with decreased PTEN levels. Altogether, our results identify PE as the first long-range tumor suppressor enhancer directly implicated in cancer.
A prospective study of 12-week respiratory outcomes in COVID-19-related hospitalisations
Authors: Aditi S Shah, Alyson W Wong, Cameron J Hague, Darra T Murphy, James C Johnston, Christopher J Ryerson, Christopher Carlsten
Journal: Thorax (2020)

The long-term respiratory morbidity of COVID-19 remains unclear. We describe the clinical, radiological and pulmonary function abnormalities that persist in previously hospitalised patients assessed 12 weeks after COVID-19 symptom onset, and identify clinical predictors of respiratory outcomes. At least one pulmonary function variable was abnormal in 58% of patients and 88% had abnormal imaging on chest CT. There was strong association between days on oxygen supplementation during the acute phase of COVID-19 and both DLCO-% (diffusion capacity of the lung for carbon monoxide) predicted and total CT score. These findings highlight the need to develop treatment strategies and the importance of long-term respiratory follow-up after hospitalisation for COVID-19.
Association of 1,5-anhydroglucitol and 2-h postprandial blood glucose in type 2 diabetic patients: response to Stettler et al. (Diabetes Care (2008) 31 (e89))
Authors: R. K. Schindhelm, M. Diamant, H. J. Bilo, R. J. Slingerland, D. M. Nathan, J. Kuenen, R. Borg, H. Zheng, D. Schoenfeld, R. J. Heine
Journal: Diabetes Care (2009)
Possible Consequences of the Approval of a Disease-Modifying Therapy for Alzheimer Disease
Authors: Erik S. Musiek, John C. Morris
Journal: JAMA Neurology (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Circulating Tumor Cell Subtypes and T-cell Populations as Prognostic Biomarkers to Combination Immunotherapy in Patients with Metastatic Genitourinary Cancer
Authors: Heather J. Chalfin, Tiziano Pramparo, Amir Mortazavi, Scot A. Niglio, Joseph D. Schonhoft, Adam Jendrisak, Yen-Lin Chu, Robin Richardson, Rachel Krupa, Amanda K.L. Anderson, Yipeng Wang, Ryan Dittamore, Sumanta K. Pal, Primo N. Lara, Mark N. Stein, David I. Quinn, Seth M. Steinberg, Lisa M. Cordes, Lisa Ley, Marissa Mallek, Olena Sierra Ortiz, Rene Costello, Jacqueline Cadena, Carlos Diaz, James L. Gulley, William L. Dahut, Howard Streicher, John J. Wright, Jane B. Trepel, Donald P. Bottaro, Andrea B. Apolo
Journal: Clinical Cancer Research (2020)

Abstract Purpose: Circulating tumor cells (CTC) are under investigation as a minimally invasive liquid biopsy that may improve risk stratification and treatment selection. CTCs uniquely allow for digital pathology of individual malignant cell morphology and marker expression. We compared CTC features and T-cell counts with survival endpoints in a cohort of patients with metastatic genitourinary cancer treated with combination immunotherapy. Experimental Design: Markers evaluated included pan-CK/CD45/PD-L1/DAPI for CTCs and CD4/CD8/Ki-67/DAPI for T cells. ANOVA was used to compare CTC burden and T-cell populations across timepoints. Differences in survival and disease progression were evaluated using the maximum log-rank test. Results: From December 2016 to January 2019, 183 samples from 81 patients were tested. CTCs were found in 75% of patients at baseline. CTC burden was associated with shorter overall survival (OS) at baseline (P = 0.022), but not on-therapy. Five morphologic subtypes were detected, and the presence of two specific subtypes with unique cellular features at baseline and on-therapy was associated with worse OS (0.9–2.3 vs. 28.2 months; P &amp;lt; 0.0001–0.013). Increasing CTC heterogeneity on-therapy had a trend toward worse OS (P = 0.045). PD-L1+ CTCs on-therapy were associated with worse OS (P &amp;lt; 0.01, cycle 2). Low baseline and on-therapy CD4/CD8 counts were also associated with poor OS and response category. Conclusions: Shorter survival may be associated with high CTC counts at baseline, presence of specific CTC morphologic subtypes, PD-L1+ CTCs, and low %CD4/8 T cells in patients with metastatic genitourinary cancer. A future study is warranted to validate the prognostic utility of CTC heterogeneity and detection of specific CTC morphologies.
Judge criticises NHS trust for delaying legal request to carry out elective caesarean on woman with severe learning disabilities
Authors: Clare Dyer
Journal: BMJ (2020)

A High Court judge has criticised a London NHS trust for leaving it until the last minute to seek court approval for an elective caesarean section for a woman with an IQ between 35 and 49, even though it knew nearly three months earlier that she would be at risk if her pregnancy went to full term.1

The woman, referred to as KB, suffered a hypoxic brain injury at birth which left her with microcephaly, epilepsy, physical disabilities, and a moderate to severe learning disability.

Mr Justice Poole said, “It is indeed disturbing that KB, a very vulnerable woman who is unable to consent to sexual relations, and who was or ought to have been constantly supervised, has had intercourse. Not only that, but no one caring for her realised that she was pregnant …
Abstract 14638: Impella Combined With Extracorporeal Membrane Oxygenation Markedly Unloads the Left Ventricle and Improves Hemodynamics in a Dog Model of Cardiogenic Shock
Authors: Genya Sunagawa, Keita Saku, Takuya Nishikawa, Takuya Akashi, Takuya Kishi, Hiroyuki Tsutsui, Kenji Sunagawa
Journal: Circulation (2018)

Introduction: In the absence of high flow (> 5L/min) transvascular left ventricular (LV) assist device, the combined use of Impella and venoarterial extracorporeal membrane oxygenation (ECMO) for c...
Low Power Bio-Impedance Sensor Interfaces: Review and Electronics Design Methodology
Authors: Jiawei Xu, Zhiliang Hong
Journal: IEEE Reviews in Biomedical Engineering (2020)

Assessing blood flow, respiration patterns, and body composition with wearable and noninvasive bio-impedance (BioZ) sensors has distinctive advantages over the conventional clinical practice. The merits of BioZ sensors derive from having long-term monitoring capability and improved user friendliness. These open up the way to build medical grade wearable devices for chronic conditions. Low power, high precision BioZ sensor interface IC is the heart of such devices, it also determines the signal integrity of the overall system. Nevertheless, electrical design challenges from both circuit and system perspective still need to be addressed. This paper reviews the pioneering BioZ interface ICs and systems, and proposes major electrical specifications for wearable BioZ sensors. System design methodologies and circuit optimization techniques are summarized as guidelines to develop the next generation BioZ interface electronics.
Abstract 14681: Left Ventricular Outflow Tract Velocity Time Integral Predicts Outcomes in Heart Failure
Authors: Christina Tan, Ajay Srivastava, Rajeev Mohan, Joshua Cheng, Jamie Felzer, Michael Barkett, Douglas Macleod, Ashley Jaravata, James T Heywood
Journal: Circulation (2017)

Introduction: Left ventricular outflow tract velocity time integral (LVOT VTI) correlates with stroke volume, reflecting cardiac pump systolic function. In patients with heart failure, lower LVOT V...
Women Physicians and Promotion in Academic Medicine
Authors: Kimber P. Richter, Lauren Clark, Jo A. Wick, Erica Cruvinel, Dianne Durham, Pamela Shaw, Grace H. Shih, Christie A. Befort, Robert D. Simari
Journal: New England Journal of Medicine (2020)

In 2000, a landmark study showed that women who graduated from U.S. medical schools from 1979 through 1997 were less likely than their male counterparts to be promoted to upper faculty ranks in academic medical centers. It is unclear whether these differences persist.
412P Treatment patterns and selection criteria for advanced non-small cell lung cancer (NSCLC) patients unfit for platinum-based first-line therapy: Results of the MOON-OSS observational trial
Authors: A. Camerini, A. Del Conte, A. Pezzuto, V. Scotti, F. Facchinetti, L.P. Ciccone, M. Perna, G. Sartori, C. Puccetti, A. Ricci, A. Santo, M. Tiseo, D. Amoroso
Journal: Annals of Oncology (2020)
Variability in Prevalence Estimates of Disability Among Children in the National Survey of Children’s Health
Authors: Thomas K. Hagerman, Amy J. Houtrow
Journal: JAMA Pediatrics (2020)

administered for the same age groups was 16 146 (1648), 1330 (408), and 1529 (623), respectively.This equates to a drop in mean immunization rate between time periods of 31% for individuals aged 0 to 2 years, 78% for those aged 3 to 9 years, and 82% for those aged 10 to 17 years.All age groups had a significant drop in immunizations immediately following social distance guidance release (March 15, 2020).In individuals aged 0 to 2 years, the rate of immunizations dropped by 4581 (95% CI, 2965-6196) immunizations per week (P<.001).In individuals aged 3 to 9 years, it dropped by 2486 (95% CI, 568-4408) immunizations per week (P > .99),and in individuals aged 10 to 17 years, it dropped by 4060 (95% CI, 2156-5965) immunizations per week (P<.001)(Figure 1).While the pre-social distancing trend was declining by 405 (95% CI, 203-607) immunizations per week, the post-social distancing trends were not significant for all age categories.Trends were similar for Haemophilus influenzae type b; 13-valent pneumococcal conjugate; and measles, mumps and rubella vaccines (Figure 2).Discussion | Since the onset of the COVID-19 pandemic, vaccination uptake in children and adolescents has shown a significant decrease in Colorado.While the clinical implications of our observation are not yet known, public health advocates should consider addressing this drop to avoid the potential for vaccine-preventable diseases.Primary care professionals should consider implementing reminders and recalls to parents, 3 and local and state health departments should consider implementing immunization registry-based recall. 4Limitations of this report include its ecological nature, being limited to a single state, and the potential for missing data.
Tryptophan Metabolism as a Pharmacological Target
Authors: Morgane Modoux, Nathalie Rolhion, Sridhar Mani, Harry Sokol
Journal: Trends in Pharmacological Sciences (2020)

L-Tryptophan (L-Trp) is metabolized via three pathways: the indole pathway in bacteria and the kynurenine and serotonin pathways in mammalian cells.Disruptions in L-Trp metabolism are reported in several diseases making L-Trp metabolism a promising therapeutic target.Manipulating L-Trp metabolism is an attractive therapeutic strategy.Key enzymes of L-Trp metabolism are targets of inhibitors currently undergoing clinical trials in cancerology, dermatology, and gastroenterology.Serotonin and aryl hydrocarbon receptor (AhR) receptors are targeted in the treatment of gastrointestinal diseases, inflammation, and many cancers.Next-generation probiotics producing indoles are being developed for their ability to activate AhR in the gut. L-Tryptophan is an essential amino acid required for protein synthesis. It undergoes an extensive and complex metabolism along several pathways, resulting in many bioactive molecules acting in various organs through different action mechanisms. Enzymes involved in its metabolism, metabolites themselves, or their receptors, represent potential therapeutic targets, which are the subject of dynamic research. Disruptions in L-tryptophan metabolism are reported in several neurological, metabolic, psychiatric, and intestinal disorders, paving the way to develop drugs to target it. This review will briefly describe L-tryptophan metabolism and present and discuss the most recent pharmacological developments targeting it. L-Tryptophan is an essential amino acid required for protein synthesis. It undergoes an extensive and complex metabolism along several pathways, resulting in many bioactive molecules acting in various organs through different action mechanisms. Enzymes involved in its metabolism, metabolites themselves, or their receptors, represent potential therapeutic targets, which are the subject of dynamic research. Disruptions in L-tryptophan metabolism are reported in several neurological, metabolic, psychiatric, and intestinal disorders, paving the way to develop drugs to target it. This review will briefly describe L-tryptophan metabolism and present and discuss the most recent pharmacological developments targeting it.
Comparison of Prehospital Scales for Predicting Large Anterior Vessel Occlusion in the Ambulance Setting
Authors: T. Truc My Nguyen, Ido R. van den Wijngaard, Jan Bosch, Eduard van Belle, Erik W. van Zwet, Tamara Dofferhoff-Vermeulen, Dion Duijndam, Gaia T. Koster, Els L. L. M. de Schryver, Loet M. H. Kloos, Karlijn F. de Laat, Leo A. M. Aerden, Stas A. Zylicz, Marieke J. H. Wermer, Nyika D. Kruyt
Journal: JAMA Neurology (2020)

The efficacy of endovascular thrombectomy (EVT) for symptomatic large anterior vessel occlusion (sLAVO) sharply decreases with time. Because EVT is restricted to comprehensive stroke centers, prehospital triage of patients with acute stroke codes for sLAVO is crucial, and although several prediction scales are already in use, external validation, head-to-head comparison, and feasibility data are lacking.To conduct external validation and head-to-head comparisons of 7 sLAVO prediction scales in the emergency medical service (EMS) setting and to assess scale feasibility by EMS paramedics.This prospective cohort study was conducted between July 2018 and October 2019 in a large urban center in the Netherlands with a population of approximately 2 million people and included 2 EMSs, 3 comprehensive stroke centers, and 4 primary stroke centers. Participants were consecutive patients aged 18 years or older for whom an EMS-initiated acute stroke code was activated. Of 2812 acute stroke codes, 805 (28.6%) were excluded, because no application was used or no clinical data were available, leaving 2007 patients included in the analyses.Applications with clinical observations filled in by EMS paramedics for each acute stroke code enabling reconstruction of the following 7 prediction scales: Los Angeles Motor Scale (LAMS); Rapid Arterial Occlusion Evaluation (RACE); Cincinnati Stroke Triage Assessment Tool; Prehospital Acute Stroke Severity (PASS); gaze-face-arm-speech-time; Field Assessment Stroke Triage for Emergency Destination; and gaze, facial asymmetry, level of consciousness, extinction/inattention.Planned primary and secondary outcomes were sLAVO and feasibility rates (ie, the proportion of acute stroke codes for which the prehospital scale could be reconstructed). Predictive performance measures included accuracy, sensitivity, specificity, the Youden index, and predictive values.Of 2007 patients who received acute stroke codes (mean [SD] age, 71.1 [14.9] years; 1021 [50.9%] male), 158 (7.9%) had sLAVO. Accuracy of the scales ranged from 0.79 to 0.89, with LAMS and RACE scales yielding the highest scores. Sensitivity of the scales ranged from 38% to 62%, and specificity from 80% to 93%. Scale feasibility rates ranged from 78% to 88%, with the highest rate for the PASS scale.This study found that all 7 prediction scales had good accuracy, high specificity, and low sensitivity, with LAMS and RACE being the highest scoring scales. Feasibility rates ranged between 78% and 88% and should be taken into account before implementing a scale.
再発または難治性骨髄腫患者における自己幹細胞移植の高用量ゲムシタビン,ブスルファン,およびメルファラン:メルファランを用いた第2相試験とマッチドペア比較【Powered by NICT】
Authors: Nieto Yago, Valdez Benigno C, Pingali Sai R, Bassett Roland, Delgado Ruby, Nguyen John, Shah Nina, Popat Uday, Jones Roy B, Andersson Borje S, Gulbis Alison, Ahmed Sairah, Bashir Qaiser, Parmar Simrit, Patel Krina, Myers Alan, Rondon Gabriela, Orlowski Robert Z, Champlin Richard, Qazilbash Muzaffar
Journal: The Lancet Haematology (2017)
Total wall resection by full-thickness resection device post-hybrid endoscopic submucosal dissection of a laterally spreading tumor in the colon
Authors: Sergio Rubel Cohen, Fernando Bartolome Fluxa Garcia, Pablo Fabre, Damian Orellano Perassi, Daniel Castellon Garcia
Journal: Endoscopy (2020)

Non-lifting lesions can occur owing to fibrosis caused by multiple biopsies, submucosal tumor involvement, and lesions resulting from incomplete resections, among others. These lesions can be successfully resected using the full-thickness resection device (FTRD) [1] [2] [3] [4] [5]. Here we report the case of a patient who, after undergoing endoscopic submucosal dissection, presented with lesion recurrence. In light of this, the decision was taken to perform resection with the FTRD.
Addressing Spiritual and Religious Needs in Advanced Illness
Authors: Christian K. Alch, Kristin M. Collier, Raymond Y. Yeow
Journal: JAMA Internal Medicine (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal