tbuckley/cabot-search huggingface dataset:
Abstract 17319: Management of Advanced Heart Failure Patients With the Combined Use of CardioMEMS™ and Telehealth: A Single Center Experience in a Veteran’s Affairs Population
Authors: Nishi Patel, Amit Alam, Subash Banerjee, Nicole Minniefield, Shelley Hall, Susan Joseph, Detlef Wencker, Daniel Cheeran, Timothy Gong
Journal: Circulation (2020)

Background: Due to the Coronavirus Disease of 2019 pandemic many clinics began to utilize virtual visits in lieu of traditional office visits. It is unclear what effect this will have on outcomes and admission rates for heart failure (HF). We describe our approach and outcomes in managing HF in a Veteran’s Affairs population with previously implanted CardioMEMS™ during this time. Methods: Starting February 15 th 2020, virtual visits were utilized in patients with CardioMEMS™ during which their symptoms were discussed and medications adjusted. Patients also received weekly phone calls to ensure that they had medications and to adjust diuretics based on pulmonary artery (PA) pressure readings. They received text message reminders if a reading was missed. A nurse was also tasked to follow up on lab results. Data was collected by reviewing the charts of CardioMEMS™ patients followed in our clinic by cardiology fellows and divided into pre pandemic period of July 1 st 2018 to February 14 th 2020 and a post pandemic period of February 15 th 2020 to May 15 th 2020. Data collected included baseline demographics, number of in-office and virtual visits, hospital admissions for HF, PA pressures, and compliance with CardioMEMS™ readings. Phone calls to adjust diuretics or review labs were not counted as virtual visits. Results: In the pre-pandemic period we identified 49 patients with prior CardioMEMS™; baseline demographics are shown in Table 1A. Table 1B shows our results comparing the pre pandemic and post pandemic periods when our telemedicine program was started. Although in the post pandemic period our encounter rate was lower, our virtual program was able to maintain stable PA pressures and a lower overall hospital admission rate. Compliance with CardioMEMS™ also increased though this was not statistically significant. Conclusion: Both CardioMEMS™ and virtual visits may be used effectively to maintain low PA pressures and reduce hospital admissions for in patients with chronic HF.
Abstract 15531: Limited Relationship Between Echocardiographic Measures and Electrocardiographic Markers of Left Ventricular Dimensions in Healthy Children
Authors: Mark E Alexander, Russell Gongwer, Felicia Trachtenberg, Luann Minich, John K Triedman, Jonathan Kaltman, Richard J Czosek, Martin Tristani, Martin J LaPage, Sabrina Tsao, Andrew E Radbill, Michael Dilorenzo, Joshua R Kovach, Elizabeth A Stephenson, Christopher Janson, Chad Y Mao, Jack C Salerno, Joseph Mahgerefteh, Thomas A Pilcher, Tiffanie R Johnson, Santiago O Valdes, Lanier Jackson, Elizabeth V Saarel
Journal: Circulation (2020)

Background: Prior ECG standards in children have largely been defined without echo confirmation of normal anatomy. The Pediatric Heart Network Normal Echocardiogram Z-score Project provides a racially diverse age/sex classified group of healthy children with normal echos that included 2170 matched contemporaneous digitally acquired ECGs. We hypothesized that ECG measures and z-scores of left ventricular (LV) dimensions are correlated in healthy children. Methods: This was a secondary analysis of the previously described cohort. Six ECG measures historically associated with LV size (R V5, R V6, S V1, Q III, axis, R V6+S V1), and 13 paired echo measures were identified a-priori with LV Mass (LVMass-z) and left ventricular end diastolic volume (LVEDV-z) z-scores serving as primary echo measurement predictors. Pearson or Spearman correlations were calculated for each of the 78 ECG- echo pairs. Regression analyses were performed to assess how much variance in ECG measures was explained by variation in LV dimensions and by demographic variables (age, sex, race). Results: ECG and echo measurement correlations were significant and concordant in 41/78 (53%), though many were significant and discordant in 13, (17%) or not correlated in 24 (31%). Of the 6 ECG measures of LV size, 5 correlated in the clinically predicted direction for LV Mass-z and LVEDV-z. While many of the correlations were statistically significant, the correlations were weak (0.05-0.25). R 2 was higher for demographic variables than for echo measures in all pairs, but even with demographic variables included, the overall R 2 was &lt; 0.17. Conclusions: In a large, diverse cohort of healthy children, there was a positive association between echo measures of LV dimension and mass and the most commonly used ECG measures of LVH. However, these correlations were weak and most of the variability in ECG measures was explained by factors other than echo derived mass or volume or measured patient demographic variables. These data question the utility of traditional ECG measurements of LV size as standalone indications for further cardiac evaluation in healthy children.
111P Real-world outcomes of patients with breast cancer liver metastases treated with transarterial radioembolization: Results from CIRT, a large European prospective multi-centre observational study
Authors: D. Arnold, T. Balli, R. Cianni, B. Peynircioglu, T. Pfammatter, N. de Jong, T.K. Helmberger
Journal: Annals of Oncology (2021)
Abstract 15717: Impact of Mechanical Circulatory Support on Outcomes and In-hospital Mortality of Peripartum Cardiomyopathy Patients With Cardiogenic Shock: An Analysis of the Nis Database
Authors: Jennifer Maning, Bertrand Ebner, Louis Vincent, Jelani Grant, Sunita Mahabir, neal olarte, Odunayo P Olorunfemi, Rosario A Colombo, Sandra V Chaparro
Journal: Circulation (2020)

Background: Peripartum cardiomyopathy (PPCM) is an uncommon form of cardiomyopathy that affects young women at the end of pregnancy or in the first few months following delivery, and is associated with increased morbidity and mortality. In selected patients with cardiogenic shock (CS), mechanical circulatory support (MCS) devices improve outcomes. However, data comparing outcomes of patients with PPCM who develop CS and receive mechanical circulatory support (MCS) vs. those treated medically remains limited. Methods: Using the National Inpatient Database (NIS) we identified patients with PPCM who were treated for CS from 2012 to 2017. Primary outcome was in-hospital mortality. Multivariate analysis models were adjusted for statistically significant differences in baseline characteristics between the groups. Results: A total of 4686 patients were admitted with a diagnosis of PPCM, of these 199 patients developed cardiogenic shock. Only 50 (25.1%) patients received MCS. Patients who received MCS were less likely to have a prior ICD in place (6% vs. 23%, p = 0.008), and were more likely to suffer from end-stage renal disease (6% vs. 0.67%, p = 0.020). There were no other major differences in baseline characteristics among the two groups. The incidence of ICD implant prior to discharge (4% vs. 7.4%, p = 0.243, OR 0.39) and cardiac arrest (16% vs. 7.4%, p = 0.173, OR 2.01) was not significantly different between the groups. There was no significant difference in in-hospital mortality between those who received MCS devices and those treated medically (22% vs 10.1%, p = 0.256, OR 1.73). LOS was longer for the MCS group (23.2% vs. 13.4 mean days, p = 0.001). Conclusions: The use of MCS in PPCM patients who developed cardiogenic shock appears to offer similar survival benefit compared to those treated medically, despite being associated with longer length of stay This finding may be related to the complexity and acuity level of patients receiving MCS compared to those treated medically.
Multiparametric MRI of early tumor response to immune checkpoint blockade in metastatic melanoma
Authors: Doreen Lau, Mary A McLean, Andrew N Priest, Andrew B Gill, Francis Scott, Ilse Patterson, Bruno Carmo, Frank Riemer, Joshua D Kaggie, Amy Frary, Doreen Milne, Catherine Booth, Arthur Lewis, Michal Sulikowski, Lee Brown, Jean-Martin Lapointe, Luigi Aloj, Martin J Graves, Kevin M Brindle, Pippa G Corrie, Ferdia A Gallagher
Journal: Journal for ImmunoTherapy of Cancer (2021)

Background Immune checkpoint inhibitors are now standard of care treatment for many cancers. Treatment failure in metastatic melanoma is often due to tumor heterogeneity, which is not easily captured by conventional CT or tumor biopsy. The aim of this prospective study was to investigate early microstructural and functional changes within melanoma metastases following immune checkpoint blockade using multiparametric MRI. Methods Fifteen treatment-naïve metastatic melanoma patients (total 27 measurable target lesions) were imaged at baseline and following 3 and 12 weeks of treatment on immune checkpoint inhibitors using: T 2 -weighted imaging, diffusion kurtosis imaging, and dynamic contrast-enhanced MRI. Treatment timepoint changes in tumor cellularity, vascularity, and heterogeneity within individual metastases were evaluated and correlated to the clinical outcome in each patient based on Response Evaluation Criteria in Solid Tumors V.1.1 at 1 year. Results Differential tumor growth kinetics in response to immune checkpoint blockade were measured in individual metastases within the same patient, demonstrating significant intertumoral heterogeneity in some patients. Early detection of tumor cell death or cell loss measured by a significant increase in the apparent diffusivity (D app ) (p&lt;0.05) was observed in both responding and pseudoprogressive lesions after 3 weeks of treatment. Tumor heterogeneity, as measured by apparent diffusional kurtosis (K app ), was consistently higher in the pseudoprogressive and true progressive lesions, compared with the responding lesions throughout the first 12 weeks of treatment. These preceded tumor regression and significant tumor vascularity changes (K trans , v e , and v p ) detected after 12 weeks of immunotherapy (p&lt;0.05). Conclusions Multiparametric MRI demonstrated potential for early detection of successful response to immune checkpoint inhibitors in metastatic melanoma.
Nutritional support during the hospital stay reduces mortality in patients with different types of cancers: secondary analysis of a prospective randomized trial
Authors: L. Bargetzi, C. Brack, J. Herrmann, A. Bargetzi, L. Hersberger, M. Bargetzi, N. Kaegi-Braun, P. Tribolet, F. Gomes, C. Hoess, V. Pavlicek, S. Bilz, S. Sigrist, M. Brändle, C. Henzen, R. Thomann, J. Rutishauser, D. Aujesky, N. Rodondi, J. Donzé, A. Laviano, Z. Stanga, B. Mueller, P. Schuetz
Journal: Annals of Oncology (2021)
Phylogenomic Subsampling and the Search for Phylogenetically Reliable Loci
Authors: Nicolás Mongiardino Koch
Journal: Molecular Biology and Evolution (2021)

Abstract Phylogenomic subsampling is a procedure by which small sets of loci are selected from large genome-scale data sets and used for phylogenetic inference. This step is often motivated by either computational limitations associated with the use of complex inference methods or as a means of testing the robustness of phylogenetic results by discarding loci that are deemed potentially misleading. Although many alternative methods of phylogenomic subsampling have been proposed, little effort has gone into comparing their behavior across different data sets. Here, I calculate multiple gene properties for a range of phylogenomic data sets spanning animal, fungal, and plant clades, uncovering a remarkable predictability in their patterns of covariance. I also show how these patterns provide a means for ordering loci by both their rate of evolution and their relative phylogenetic usefulness. This method of retrieving phylogenetically useful loci is found to be among the top performing when compared with alternative subsampling protocols. Relatively common approaches such as minimizing potential sources of systematic bias or increasing the clock-likeness of the data are found to fare worse than selecting loci at random. Likewise, the general utility of rate-based subsampling is found to be limited: loci evolving at both low and high rates are among the least effective, and even those evolving at optimal rates can still widely differ in usefulness. This study shows that many common subsampling approaches introduce unintended effects in off-target gene properties and proposes an alternative multivariate method that simultaneously optimizes phylogenetic signal while controlling for known sources of bias.
Abstract 3228: Feasibility and Limitations of “Automatic” Mapping and Pre-Designed Computer Assisted Ablation of Atrial Fibrillation Using the Stereotaxis Navigation System
Authors: Mark W Kolasa, Yong-Mei Cha, Paul A Friedman, Win-Kuang Shen, Laura A Peterson, Douglas L Packer
Journal: Circulation (2007)

Introduction: Combination of magnetic catheter guidance and electroanatomic (EA) mapping may provide additional capability for the automated ablation of advanced arrhythmias. Nevertheless, automati...
56P The impact of tumour detection method on genomic and clinical risk and chemotherapy recommendation in early hormone receptor positive breast cancer
Authors: Y. Bar, K. Bar, I. Itzhak, C. Shitrit Niselbaum, N. Dershowitz, E. Shachar, A. Weiss-Meilik, O. Golan, I. Wolf, T. Menes, A. Sonnenblick
Journal: Annals of Oncology (2021)
Abstract 063: Racial/Ethnic Differences In Blood Pressure Around The Time Of The 2016 United States General Election
Authors: Andrew Y Hwang, Michelle I Cardel, Steven M Smith
Journal: Circulation (2021)

Introduction: Politics are a major source of stress and anxiety among U.S. adults, and the 2016 U.S. general election may have led to increased psychosocial stress among different racial/ethnic populations. Psychosocial stress can manifest physiologically in elevated blood pressure (BP). Yet, little is known regarding whether this response differs among racial/ethnic groups. We sought to characterize population-level changes in BP among non-Hispanic (NH) Whites, NH Blacks, and Mexican Americans before and after the 2016 U.S. general election. Methods: Using cross-sectional 2015-2018 National Health and Nutrition Examination Survey (NHANES) data, we included participants aged ≥20 years with ≥1 systolic BP (SBP) and diastolic BP (DBP) measurement during the examination periods just prior to and after the election. The pre-election period was from May 2016 to October 2016 and the post-election period was from November 2017 to April 2018. Survey-weighted data were analyzed to compare mean SBP and DBP pre- and post-election, stratified by race/ethnicity. Stratified analyses were also performed on hypertension status, defined as self-report, mean BP ≥140/90, or use of ≥1 antihypertensive drug. Results: We included 1,060 NH Whites, 720 NH Blacks, and 223 Mexican Americans during the pre-election period and 676 NH Whites, 564 NH Blacks, and 468 Mexican Americans during the post-election period. We observed a significant increase in SBP among Mexican Americans (mean±SEM, 118±0.5 mmHg [pre-election] vs. 121.7±0.7 mmHg [post-election], p=0.005), but not among NH Blacks (126.7±0.9 mmHg vs. 128.9±0.7 mmHg, p=0.083) nor NH Whites (123±0.6 mmHg vs. 124.8±1.4 mmHg, p=0.256). DBP increased among both Mexican Americans (69.5±0.5 mmHg vs. 72.6±1.1 mmHg, p=0.022) and NH Blacks (72.2±0.8 mmHg vs. 74.9±0.6 mmHg, p=0.012), but not among NH Whites (70.4±0.4 mmHg vs. 72.9±1.3 mmHg, p=0.075). These effects were largely attributable to BP changes among those with hypertension (pre-election: 414 NH Whites, 350 NH Blacks, 60 Mexican Americans; post-election: 330 NH Whites, 298 NH Blacks, 156 Mexican Americans), in whom there was an increase in SBP among NH Blacks (138.8±1.3 mmHg vs. 143.7±1.7 mmHg, p=0.032) and Mexican Americans (133.9±1.1 mmHg vs. 141.9±1.5 mmHg, p=0.0002); and an increase in DBP among NH Blacks (76.2±1.2 mmHg vs. 80.8±0.9 mmHg, p=0.005). No significant changes were observed in any racial/ethnic group without hypertension. Conclusions: At the population-level, NH Blacks and Mexican Americans had increases in BP following the 2016 U.S. general election, largely driven by BP elevations among those with hypertension. Patient-level data, especially linked with political affiliation, may provide additional insights into the psychosocial stress effect of major political events.
Suppression of ACADM-Mediated Fatty Acid Oxidation Promotes Hepatocellular Carcinoma via Aberrant CAV1/SREBP1 Signaling
Authors: Angel P.Y. Ma, Cherlie L.S. Yeung, Sze Keong Tey, Xiaowen Mao, Samuel W.K. Wong, Tung Him Ng, Frankie C.F. Ko, Ernest M.L. Kwong, Alexander H.N. Tang, Irene Oi-Lin Ng, Shao Hang Cai, Jing Ping Yun, Judy W.P. Yam
Journal: Cancer Research (2021)

Abstract Lipid accumulation exacerbates tumor development, as it fuels the proliferative growth of cancer cells. The role of medium-chain acyl-CoA dehydrogenase (ACADM), an enzyme that catalyzes the first step of mitochondrial fatty acid oxidation, in tumor biology remains elusive. Therefore, investigating its mode of dysregulation can shed light on metabolic dependencies in cancer development. In hepatocellular carcinoma (HCC), ACADM was significantly underexpressed, correlating with several aggressive clinicopathologic features observed in patients. Functionally, suppression of ACADM promoted HCC cell motility with elevated triglyceride, phospholipid, and cellular lipid droplet levels, indicating the tumor suppressive ability of ACADM in HCC. Sterol regulatory element-binding protein-1 (SREBP1) was identified as a negative transcriptional regulator of ACADM. Subsequently, high levels of caveolin-1 (CAV1) were observed to inhibit fatty acid oxidation, which revealed its role in regulating lipid metabolism. CAV1 expression negatively correlated with ACADM and its upregulation enhanced nuclear accumulation of SREBP1, resulting in suppressed ACADM activity and contributing to increased HCC cell aggressiveness. Administration of an SREBP1 inhibitor in combination with sorafenib elicited a synergistic antitumor effect and significantly reduced HCC tumor growth in vivo. These findings indicate that deregulation of fatty acid oxidation mediated by the CAV1/SREBP1/ACADM axis results in HCC progression, which implicates targeting fatty acid metabolism to improve HCC treatment. Significance: This study identifies tumor suppressive effects of ACADM in hepatocellular carcinoma and suggests promotion of β-oxidation to diminish fatty acid availability to cancer cells could be used as a therapeutic strategy.
Criminalization of Gender-Affirming Care — Interfering with Essential Treatment for Transgender Children and Adolescents
Authors: Simona Martin, Elizabeth S. Sandberg, Daniel E. Shumer
Journal: New England Journal of Medicine (2021)

Arkansas recently passed a law making it illegal for clinicians to provide gender-affirming treatment to children and adolescents with gender dysphoria. This legislation and similar bills could threaten the health, well-being, and survival of transgender young people.
One-for-all phototheranostics: Single component AIE dots as multi-modality theranostic agent for fluorescence-photoacoustic imaging-guided synergistic cancer therapy
Authors: Haifei Wen, Zhijun Zhang, Miaomiao Kang, Haoxuan Li, Wenhan Xu, Heng Guo, Youmei Li, Yonghong Tan, Ziyao Wen, Qian Wu, Jiachang Huang, Lei Xi, Kai Li, Lei Wang, Dong Wang, Ben Zhong Tang
Journal: Biomaterials (2021)
Abstract 14445: The Prevalence of Coronary Risk Factors Among Patients Undergoing Their First Percutaneous Coronary Intervention: Insights From the Blue Cross Blue Shield of Michigan Cardiovascular Consortium
Authors: Zoya Gurm, Milan Seth, Edouard Daher, Elizabeth Pielsticker, M. Imran Qureshi, Mark Zainea, Michael Tucciarone, George Hanzel, Devraj Sukul
Journal: Circulation (2020)

Background: Coronary artery disease (CAD) is the leading cause of death globally and risk factors for CAD are well established. Although there has been a decline in the incidence of CAD in recent years, understanding the risk factor profile of patients presenting with cardiac disease in contemporary practice may help define current unmet challenges in preventing CAD. Objectives: To evaluate the prevalence of CAD risk factors among patients undergoing percutaneous coronary intervention (PCI) and assess how they have changed over time. Methods: We assessed the prevalence of risk factors among patients without a history of prior myocardial infarction, PCI, or coronary artery bypass graft surgery who underwent PCI at 47 non-federal hospitals in the state of Michigan between 1/1/2010 and 3/31/2018 using the BMC2 PCI registry. Results: Our study cohort included 69,970 men and 39,106 women. Traditional risk factors were highly prevalent in this population: 34.4% of men and 31.0% of women were current or recent smokers, hypertension was present in 71.8% of men and 80.6% of women, hyperlipidemia was present in 65.0% of men and 68.9% of women, diabetes was present in 27.8% of men and 35.5% of women, and 44.8% of men and 48.0% of women were obese. Over the study period, the prevalence of diabetes (29% to 32%) and obesity (45% to 48%) increased while a decline in smoking prevalence was noted (34% to 31%). Most patients had 2 or more risk factors with 51.2% having three or more risk factors. Compared with nonsmokers, smokers presented over a decade earlier (age 56.8 versus 66.9 years, p &lt; 0.0001) and obese patients presented 4.0 years earlier (age 61.4 versus 65.4 years, p &lt; 0.0001) (Figure). Conclusions: Modifiable risk factors are widely prevalent among patients undergoing their first PCI. Population-level interventions aimed at controlling obesity and preventing smoking could significantly delay the onset of CAD and the need for PCI.
Abstract 15309: Prevalence, Predictors, and Outcomes of Patients With Tachycardia-Related Cardiomyopathy Due to Atrial Fibrillation
Authors: Athittaya Techawantochandej, Hon-Chi Lee, Bernard J Gersh, Waldemar E Wysokinski, Sri Harsha Patlolla, Eddie L Greene, Jae K Oh, Rowlens M Melduni
Journal: Circulation (2018)

Introduction: Tachycardia-induced cardiomyopathy (TICM) is a potentially reversible condition characterized by left ventricular (LV) dilatation and systolic dysfunction mediated by tachyarrhythmias...
Cyclosporin A in patients receiving renal allografts from cadaver donors. 1978.
Authors: R Y Calne, S Thiru, P McMaster, G N Craddock, D J White, D J Evans, D C Dunn, B D Pentlow, K Rolles
Journal: Journal of the American Society of Nephrology (1998)

Calne, R Y; Thiru, S; McMaster, P; Craddock, G N; White, D J; Evans, D J; Dunn, D C; Pentlow, B D; Rolles, K