tbuckley/cabot-search huggingface dataset:
Evidence-Based Guidelines to Eliminate Repetitive Laboratory Testing?
Authors: Renuka S. Bindraban, Maarten J. ten Berg, Christiana A. Naaktgeboren
Journal: JAMA Internal Medicine (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Redundancy reduction for improved display and analysis of body surface potential maps. II. Temporal compression.
Authors: A K Evans, R L Lux, M J Burgess, R F Wyatt, J A Abildskov
Journal: Circulation Research (1981)

This paper describes use of the Karhunen-Loeve expansion to identify and reduce temporal redundancy in electrocardiographic body surface potential maps (192 body surface leads recorded simultaneously at 1 kHz/channel for approximately 600 msec). Temporal data compression of about 20 to 1 was obtained with accurate representation of the original data. Use of separate sets of orthonormal basis functions for QRS and ST-T provided a more accurate representation than the basis derived from QRST. Combined with the spatial compression described in the preceding paper, overall map data compression of about 320 to 1 was obtained without significant loss of accuracy of representation or map appearance. With both spatial and temporal compression the 100,000 numbers which typically comprise a single cardiac complex were accurately represented by 216 coefficients. Using basis functions derived from a single cardiac complex were accurately represented by 216 coefficients. Using basis functions derived from a training set of 221 maps, the estimated average rms error of representation was 60 microV during the ST-T. For 34 test maps which were not part of the training set, measured average errors were 64 microV during the QRS and 23 microV during the ST-T. This technique provides a basis for quantification of the diagnostic content of maps and automated classification of maps.
Small-Molecule Natural Product Physachenolide C Potentiates Immunotherapy Efficacy by Targeting BET Proteins
Authors: Poonam Tewary, Alan D. Brooks, Ya-Ming Xu, E.M. Kithsiri Wijeratne, Ashley L. Babyak, Timothy C. Back, Raj Chari, Christine N. Evans, Curtis J. Henrich, Thomas J. Meyer, Elijah F. Edmondson, Maria T. Prudente de Aquino, Thanigaivelan Kanagasabai, Anil Shanker, A.A. Leslie Gunatilaka, Thomas J. Sayers
Journal: Cancer Research (2021)

Abstract Screening for sensitizers of cancer cells to TRAIL-mediated apoptosis identified a natural product of the 17β-hydroxywithanolide (17-BHW) class, physachenolide C (PCC), as a promising hit. In this study, we show that PCC was also able to sensitize melanoma and renal carcinoma cells to apoptosis in response not only to TRAIL, but also to the synthetic polynucleotide poly I:C, a viral mimetic and immune activator, by reducing levels of antiapoptotic proteins cFLIP and Livin. Both death receptor and TLR3 signaling elicited subsequent increased assembly of a proapoptotic ripoptosome signaling complex. Administration of a combination of PCC and poly I:C in human M14 melanoma xenograft and a syngeneic B16 melanoma model provided significant therapeutic benefit as compared with individual agents. In addition, PCC enhanced melanoma cell death in response to activated human T cells in vitro and in vivo in a death ligand–dependent manner. Biochemical mechanism-of-action studies established bromo and extraterminal domain (BET) proteins as major cellular targets of PCC. Thus, by targeting of BET proteins to reduce antiapoptotic proteins and enhance caspase-8–dependent apoptosis of cancer cells, PCC represents a unique agent that can potentially be used in combination with various immunotherapeutic approaches to promote tumor regression and improve outcome. Significance: These findings demonstrate that PCC selectively sensitizes cancer cells to immune-mediated cell death, potentially improving the efficacy of cancer immunotherapies.
Synergistic hypotensive effect of vasoactive intestinal polypeptide and alpha-blockade with phentolamine. Evidence for vasoactive intestinal peptide alpha-adrenoceptor coupling in the cardiovascular system of newborn dogs.
Authors: M SMas, D JAdams, HGelband
Journal: Circulation Research (1990)

Vasoactive intestinal polypeptide (VIP) is a neuropeptide with potent circulatory effects in the adult animal and human. Little is known about its effects or mechanism of action in the immature animal. These series of experiments evaluated the effects and possible mechanism of action of VIP on the developing canine cardiovascular system. In all three series, measurements of mean heart rate and blood pressure were taken in the control state, after parasympathetic denervation with bilateral cervical vagotomies, and after autonomic blockade with propranolol (1 mg/kg) and phentolamine (0.5 mg i.v.). In series 1, we characterized the role of alpha-adrenergic receptors in early newborn puppies by investigating the hemodynamic effects of phentolamine alone in five early newborn puppies. In series 2, the hemodynamic effects of intravenous VIP infusion (0.2 microgram/kg/min) were recorded and compared in six early newborn puppies and in 10 late newborn puppies. In series 3, the hemodynamic effects of phentolamine ...
Doing Better and Feeling Worse. Health in the United States.
Journal: Annals of Internal Medicine (1977)

This is a book that will generate debate, discussion, controversy, conflict, and perhaps some legislative reform when the impact of its arguments begins to be felt. Twenty doctors, economists, and political and social scientists were asked by the Rockefeller Foundation to write on health and medical care in the United States. A clue to their opinions about the state of the nation's health is the title of their volume. Doing Better and Feeling Worse.
Endoscopic Submucosal Dissection (ESD): How do Western Endoscopists Value Animal Models?
Authors: R Küttner-Magalhães, P Pimentel-Nunes, M Araújo-Martins, D Libânio, M Borges-Canha, R Marcos-Pinto, A Koch, M Dinis-Ribeiro
Journal: Endoscopy (2021)

Aims Endoscopic Submucosal Dissection (ESD) was introduced in the West later than in East, which might have influenced the type of training on this technique. Only recently, suggestions for standardized training were described. Our aim was to assess how Western endoscopists performing ESD have been trained and how they value animal models for training.
Acute middle ear infection (acute otitis media) in children
Authors: Roderick P Venekamp, Anne G M Schilder, Maaike van den Heuvel, Alastair D Hay
Journal: BMJ (2020)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Acute middle ear infection (acute otitis media) in children Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Digital-Single-Operator Pancreatoscopy Guided Lithotripsy for Pancreatic Duct Stones In Symptomatic, Treatment Refractory Chronic Pancreatitis. Long-Term Follow-Up on Clinical, Technical Success and Quality of Life
Authors: C Gerges, T Dertmann, M Schneider, Siersema PD, E-JM van Geenen, H Neuhaus, T Beyna
Journal: Endoscopy (2021)

Aims Pancreatic duct(PD) stones in patients with chronic calcifying pancreatitis(CCP) often contribute to pain and have a negative impact on quality of life(QOL). Therefore pancreatic duct clearance and drainage is the main goal in surgical and interventional therapy strategies. Digital-single-operator-video-pancreatoscopy (d-SOVP) guided lithotripsy was shown to achieve very high technical and clinical success rates(95 %) in a short-term follow-up. However, there is only little evidence of long-term success or impact on quality of life.
Efficacy And Safety of Endoscope-Guided Pneumatic Dilation for Treatment of Esophageal AchalasiA
Authors: A Hammami, R Harbi, W Ben Ameur, W Dahmani, N Elleuch, A Braham, S Ajmi, A Ben Slama, M Ksiaa, H Jaziri, A Jmaa
Journal: Endoscopy (2021)

Aims Pneumatic dilation (PD) is considered the first line therapy for achalasia. The aim of our work is to evaluate the efficiency of this procedure and to establish the predictive factors of its failure.
Covid-19，失业和健康：更深层次解决方案的时间？
Authors: 马丁赫瑟尔
Journal: BMJ (2020)

随着Covid-19在世界各地的失业率下降到几代人，一旦激进的经济政策建议正在迅速获得听证会。Martin Hensher审查工作保障或普遍基本收入计划如何支持更好的健康和更好的经济学
Hemodynamics and coronary blood flow during exercise after coronary artery bypass grafting with internal mammary arteries in children with Kawasaki disease.
Authors: KKawachi, SKitamura, TSeki, RMorita, TKawata, JHasegawa, YKameda
Journal: Circulation (1991)

BACKGROUNDSaphenous vein grafts (SVG) and internal mammary artery (IMA) grafts have been used for coronary artery bypass grafting. In adult patients with bypass grafting for atherosclerotic coronary artery disease, IMA grafts have been reported to have long-term patency; however, results are conflicting on whether the graft is sufficient to meet increased myocardial oxygen demand during exercise. There have been no studies on hemodynamics and blood flow during exercise after bypass grafting with IMA in pediatric patients with Kawasaki disease.METHODS AND RESULTSWe studied 17 pediatric patients with Kawasaki disease (average age, 7.5 +/- 3.1 years), who underwent coronary artery bypass grafting with the IMA. The average number of coronary artery bypass grafts was 2.1 +/- 0.7/patient. For all patients, the left IMA was anastomosed to the left anterior descending coronary artery; for eight patients, the right IMA was also anastomosed to the right coronary artery. In addition, 11 SVGs were used. The postopera...
Temperature monitoring during radiofrequency catheter ablation of accessory pathways.
Authors: J JLangberg, HCalkins, Rel-Atassi, MBorganelli, ALeon, S JKalbfleisch, FMorady
Journal: Circulation (1992)

BACKGROUNDAnimal studies have suggested that the temperature of the electrode-tissue interface during radiofrequency catheter ablation accurately predicts lesion size. The purpose of the current study was to evaluate the utility of continuous temperature monitoring during radiofrequency catheter ablation in patients with Wolff-Parkinson-White syndrome.METHODS AND RESULTSTwenty patients with manifest preexcitation were included in the study. The ablation catheter was positioned on the ventricular side of the mitral annulus for left-sided accessory pathways and on the atrial side of the tricuspid annulus for right-sided and septal accessory pathways. A thermistor imbedded in the distal electrode of the ablation catheter allowed continuous temperature monitoring during each energy application. To define the relation between power and temperature, radiofrequency current was applied several times at each site using outputs of 20, 30, 40, and 50 W. The accessory pathways were successfully ablated in each of the...
Clinical and Endoscopic Picture of Periampullary Tumours at a Tertiary Care Hospital
Authors: GR Rithesh, K Vijay, H Nandeesh, S Deepak, H Aradya
Journal: Endoscopy (2021)

Aims Periampullary tumour is a clinical condition often encountered by gastroenterologist. There is limited data regarding clinical profile and endoscopic management of patients with periampullary tumour.
Blockade of cardiac inflammation in Mg2+ deficiency by substance P receptor inhibition.
Authors: W BWeglicki, I TMak, T MPhillips
Journal: Circulation Research (1994)

In previous work we reported the elevation of circulating inflammatory cytokines in rodents maintained on a Mg(2+)-deficient diet. Within the first week of Mg2+ deficiency, significant elevation of the neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) occurs. The present study was designed to assess the effects of SP receptor blockade by CP-96,945 and its inactive enantiomer CP-96,344 on tissue cytokine levels and in vivo oxidative indexes. CP-96,345 had no significant effect on circulating levels of SP or CGRP; however, at the tissue level, a significant decrease (P < .01) in myocardial accumulation of SP occurred; the inactive enantiomer was only slightly effective. In addition, CP-96,345 significantly reduced (by 53%) the accumulation of tumor necrosis factor-alpha (TNF-alpha) (but not interleukin-1 and interleukin-6) within the lesions; the effect of the enantiomer was insignificant. We conclude that treatment with CP-96,345 inhibits SP and TNF-alpha tissue levels in cardiac le...
Effects of high and low sodium intake on arterial pressure and forearm vasular resistance in borderline hypertension. A preliminary report.
Authors: A LMark, W JLawton, F MAbboud, A EFitz, W EConnor, D DHeistad
Journal: Circulation Research (1975)

The purpose of this study was to evaluate effects of high and low sodium intake on arterial pressure and forearm vascular resistance in subjects with borderline hypertension and to compare responses to sodium excess in these subjects with responses in a recent study in normotensive subjects. Six subjects with borderline hypertension were studied after ten days of high (410 mEq/24hr) and low (10mEq/24hr) sodium intake. Potassium intake was constant. In five of six subjects, high sodium intake decreased forearm blood flow and increased forearm vascular resistance and arterial pressure. During low and high sodium intake forearm blood flow averaged 7.8 plus or minus 1.2 (SE) and 5.9 plus or minus 0.8 ml/min x 100 ml, respectively; forearm vascular resistance averaged 13.5 plus or minus 2.2 and 19.1 plus or minus 3.0 units, respectively; and mean arterial pressure averaged 89 plus or minus 3 and 98 plus or minus 2 mm Hg, respectively. High sodium intake augmented forearm vasoconstrictor responses to lower body...
Regulation of E-cadherin and vitamin D receptor by SNAIL and ZEB1 in colon cancer
Authors: Cristina Peña, Jose Miguel García, Vanesa García, Javier Silva, Gemma Domínguez, Raquel Díaz, Yolanda Lorenzo, Dolores Chaparro, Rufo Rodríguez, Felix Bonilla
Journal: Cancer Research (2006)

120  E-cadherin, encoded by CDH1 gene, contributes to the maintenance of the adhesive and polarized phenotype of epithelial cells and its expression is strictly regulated. When E-cadherin is down-regulated, the epithelial cells acquire a fibroblastoid morphotype, accompanied by acquisition of invasive and migratory properties, a critical event during invasion and metastasis of carcinoma cells. SNAIL and ZEB1 are zinc finger transcription factors involve in CDH1 repression. In contrast, the active metabolite of vitamin D, 1α,25-dihydroxyvitamin D3, induces the expression of E-cadherin gene in cells expressing the nuclear vitamin D receptor (VDR) which is a ligand-modulated transcription factor. We study the expression and functional correlation of these four genes and examine their possible involvement in colon cancer. The expression of SNAIL, CDH1, VDR and ZEB1 genes was measured by RT-PCR in 114 patients with colorectal cancer, and tumor characteristics were analyzed in each patient. Using epithelial enriched cell populations of tumor samples, we determined that changes expression of SNAIL and ZEB1 were due to deregulation of these genes in epithelial cells and not in mesenchymal cells. No significant intra-tumor differences were found in E-cadherin staining by immunostaining and all of the E-cadherin protein negative tumors showed low mRNA expression levels. SNAIL mRNA expression was detected in 72 of 114 patients (63.2%) and was associated with downregulation of CDH1 (p
Improvement of treadmill capacity and collateral circulation as a result of exercise with heparin pretreatment in patients with effort angina.
Authors: MFujita, SSasayama, HAsanoi, HNakajima, OSakai, AOhno
Journal: Circulation (1988)

It has been demonstrated in animal experiments that heparin accelerates the coronary collateral development induced by repeated coronary occlusion. We used this effect of heparin for the treatment of patients with stable effort angina. In 10 patients, treadmill exercise was performed according to standard Bruce protocol twice a day for 10 days. A single intravenous dose of heparin (5000 IU) was given 10 to 20 min before each exercise period. Exercise with heparin pretreatment increased the total exercise duration from 6.3 +/- 1.9 (SD) to 9.1 +/- 2.2 min (p less than .001) and the maximal double product (DP) from 18,900 +/- 5100 to 25,500 +/- 6800 mm Hg.beats/min (p less than .001). The DP at the onset of angina was also increased by 35% (p less than .01) and the DP at which ST depression (0.1 mV) first appeared was 19% (p less than .05) greater after treatment. Repeat coronary cineangiography revealed an increase in the extent of opacification of collaterals to the jeopardized myocardium. In an additional...
Role of cardiac ATP-regulated potassium channels in differential responses of endocardial and epicardial cells to ischemia.
Authors: TFurukawa, SKimura, NFurukawa, A LBassett, R JMyerburg
Journal: Circulation Research (1991)

Epicardial cells are more susceptible to the electrophysiological effects of ischemia than are endocardial cells. To explore the ionic basis for the differential electrophysiological responses to ischemia at the two sites, we used patch-clamp techniques to study the effects of ATP depletion on action potential duration and the ability of ATP-regulated K+ channels in single cells isolated from feline left ventricular endocardial and epicardial surfaces. During ATP depletion by treatment with 1 mM cyanide (CN-), shortening of action potential durations was significantly greater in epicardial cells than in endocardial cells. Thirty minutes after initiating exposure to 1 mM CN-, action potential duration at 90% repolarization was reduced to 0.70 +/- 0.12 of the control value for endocardial cells versus 0.39 +/- 0.18 for epicardial cells (p less than 0.01), and action potential duration at 20% repolarization was reduced to 0.72 +/- 0.13 for endocardial cells versus 0.12 +/- 0.09 for epicardial cells (p less t...
Hypertensive rats produced by in vivo introduction of the human renin gene.
Authors: NTomita, JHigaki, YKaneda, HYu, RMorishita, HMikami, TOgihara
Journal: Circulation Research (1993)

We established an efficient and nontoxic in vivo gene transfer method mediated by the Sendai virus (hemagglutinating virus of Japan [HVJ]), liposomes, and nuclear protein. In this study, to produce a hypertensive model rat that is dependent on human renin, the human renin gene was introduced into adult rat liver by our efficient in vivo gene transfer method using HVJ and liposomes (HVJ-liposomes). The rats treated with HVJ-liposomes containing the human renin gene showed a significant elevation of blood pressure for 6 days compared with control rats, which received injections of HVJ-liposomes without the human renin gene. On day 5 after the transfer, human active renin as well as angiotensin II were found in the plasma of rats in which the human renin gene was introduced. Moreover, the blood pressure of these rats was significantly correlated with the plasma levels of human active renin and angiotensin II. To confirm that the elevated blood pressure was due to the expression of the human renin gene, we ad...
Cardiac growth after pediatric heart transplantation.
Authors: DBernstein, SKolla, MMiner, PPitlick, MGriffin, VStarnes, RRowan, MBillingham, DBaum
Journal: Circulation (1992)

BACKGROUNDTo assess whether normal cardiac growth occurs after heart transplantation in the pediatric age group, we performed a study of 13 infants and children who underwent orthotopic heart transplantation at Stanford.METHODS AND RESULTSThe echocardiographic data from a population of 93 normal children were analyzed to determine estimates of the fifth, 25th, 50th, 75th, and 95th percentiles of the normal pediatric population. Growth curves for each of the cardiac dimensions were stratified into six classes representing each of the percentile bands, and dimensions for the 13 patients were tracked between early postoperative (early) and point of maximal follow-up (late). Results were compared by Student's paired t test to determine whether normal growth was occurring. The mean age at transplant was 5.0 +/- 1.3 years (mean +/- SEM) (range, 0.4-12.8 years), duration of follow-up was 3.1 +/- 0.4 years (1.3-5.8 years), and change in body surface area was 0.24 +/- 0.03 m2 (0.12-0.50 m2). Both right ventricular...