tbuckley/cabot-search huggingface dataset:
Additional Analyses of a Randomized Phase II Study of Azacitidine Combined with Lenalidomide or with Vorinostat Vs. Azacitidine Monotherapy in Higher-Risk Myelodysplastic Syndromes (MDS) and Chronic Myelomonocytic Leukemia (CMML): North American Intergroup Study SWOG S1117
Authors: Mikkael A. Sekeres, Megan Othus, Alan F. List, Olatoyosi Odenike, Richard M. Stone, Steven D. Gore, Mark R Litzow, Rena Buckstein, Min Fang, Diane Roulston, Clara D. Bloomfield, Yanming Zhang, Mario R. Velasco, Rakesh Gaur, Ehab Atallah, Eyal C. Attar, Frederick R Appelbaum, Harry P. Erba
Journal: Blood (2015)
Use of Domain-Deletion Mutants to Locate Lutheran Blood Group Antigens to Each of the Five Immunoglobulin Superfamily Domains of the Lutheran Glycoprotein: Elucidation of the Molecular Basis of the Lua/Lub and the Aua/Aub Polymorphisms
Authors: S.F. Parsons, G. Mallinson, G.L. Daniels, C.A. Green, J.S. Smythe, D.J. Anstee
Journal: Blood (1997)
Genetic Modification of Human B-Cell Development: B-Cell Development Is Inhibited by the Dominant Negative Helix Loop Helix Factor Id3
Authors: Ana C. Jaleco, Alexander P.A. Stegmann, Mirjam H.M. Heemskerk, Franka Couwenberg, Arjen Q. Bakker, Kees Weijer, Hergen Spits
Journal: Blood (1999)
Abstract 220: The Cardioprotective Kinase, Akt, Modulates Mitochondrial Dynamics
Authors: Derek J Hausenloy, Sara Cipolat, Derek M Yellon, Luca Scorrano
Journal: Circulation (2007)

Mitochondria exist in a dynamic state of fragmentation (fission) and elongation (fusion), termed mitochondrial dynamics. Studies suggest that mitochondrial fragmentation precedes apoptosis and that...
Abstract P287: Complement Proteins C3 and C4 are Associated with Higher Levels of Hemostatic Markers in Women at Midlife: The Study of Women's Health Across the Nation
Authors: Samar R El Khoudary, Kelly J Shields, Hsiang-Yu Chen, Karen A Matthews, Kim Sutton-Tyrrell
Journal: Circulation (2013)

Objective: Complement proteins have been associated with atherosclerosis and cardiovascular risk factors. Recent data suggest a potential role of complement protein C3 in clot stability with hypofi...
Physiologic force-frequency response in engineered heart muscle by electromechanical stimulation
Authors: Amandine F.G. Godier-Furnémont, Malte Tiburcy, Eva Wagner, Matthias Dewenter, Simon Lämmle, Ali El-Armouche, Stephan E. Lehnart, Gordana Vunjak-Novakovic, Wolfram-Hubertus Zimmermann
Journal: Biomaterials (2015)
Abstract 311: Poly(ADP-ribose) Polymerase-1 Inhibition Prevents High Fat Diet-induced Cardiac Hypertrophy by Modulating Matrix-destabilizing Proteases and Oxidative Stress
Authors: Chetan P Hans, Yumei Feng, Amarjit Naura, Mourad Zerfaoui, Dana Troxclair, Khalid Matrougui, Eric Lazartigues, Hamid Boulares
Journal: Circulation (2008)

Background: We recently showed that PARP-1 is activated within atherosclerotic plaques and that inhibition of this enzyme, exerts protective effects against high fat diet-induced atherogenesis. Given the tight association between atherosclerosis and cardiac pathologies, we examined, whether PARP-1 is an active participant in high fat diet-induced cardiac hypertrophy and whether PARP-1 gene knockout prevents such pathological abnormalities. Methods: Apolipoprotein (ApoE)−/− mice fed a high-fat diet were used as a model of atherosclerosis. C57BL/6 ApoE−/− mice that are deficient in PARP-1 (ApoE-PARP-1d−/−) were generated in our laboratory. Hemodynamic parameters were obtained by a small animal-adapted ultrasound imaging system. Results: Hemodynamic parameters revealed that ApoE−/− mice on regular diet exhibited markers of cardiac hypertrophy. PARP-1 gene knockout markedly protected against dyslipidemia-induced cardiac hypertrophy. An increase in dyslipidemia burden further exacerbated the latter parameters in ApoE−/− mice. Inhibition of PARP-1 by gene deletion provided a significant protection against the parameters of cardiac hypertrophy. Histology showed enlarged hypertrophied cardiac myocytes in ApoE−/− mice with typical “boxcar-shaped” nuclei and high-fat diet caused separation of the myocardial fibers suggestive of dilated cardiomyopathy in these mice. PARP-1 gene deletion maintained the structural integrity of cardiac myocytes. MMP activity, measured by zymography, was dramatically increased in heart and aorta of ApoE−/− mice on high-fat diet compared to ApoE-PARP-1d−/− mice on similar diet regimen, which was accompanied by increased collagen degradation and mast cell degranulation. PARP-1 gene knockout was associated with increased TIMP-2 expression in various cells of vascular origin which seemed to neutralize the degenerative effects of MMP activity. Discussion: Our results demonstrate that PARP-1 gene deletion protects against dyslipidemia-induced cardiac hypertrophy and dilatations. We also provide evidence that PARP-1 inhibition protects against these pathologies by increasing expression of TIMP-2 and subsequent inhibition of tissue-degrading proteases in a mouse model of atherosclerosis.
Life of the Red Cell
Authors: L J WITTS
Journal: BMJ (1950)

ASTHMA MEDICAL JOURNAL conditions not apparently related to the asthma may also be higher than for the normal individual.These hazards must be recognized and their risk reduced by careful and thorough treatment at an early stage, and at all times the serious nature of the disease must be appreciated.SAll doses mentioned in this paper apply to adults: appropriate reauction should be made for children.)REFERENCES
Management of Anomalous Coronary Artery From the Contralateral Coronary Sinus⁎⁎Editorials published in the Journal of American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Authors: Welton M. Gersony
Journal: Journal of the American College of Cardiology (2007)
Abstract 16009: Frequent, Episodic Alcohol Consumption Alters Macro-and Micro-Vascular Reactivity in Young Adults
Authors: Melissa M Goslawski, Jing-Tan Bian, Mary Szczurek, Mariann R Piano, Shane A Phillips
Journal: Circulation (2011)

Introduction: Previous studies have shown that individuals who engage in binge drinking (≥5 alcohol drinks/ 2 hours: men; ≥4 alcohol drinks/2 hours: women) at least once every two weeks have simila...
Abstract 11551: Posterior Cerebral Autoregulation is More Vulnerable to Hypotension as Compared to Anterior Cerebral Autoregulation in Older Adults
Authors: Jie Liu, Candace Hill, Kyle Armstrong, Takashi Tarumi, Timea Hodics, Rong Zhang
Journal: Circulation (2013)

Differences in regional cerebral autoregulation (CA) may be responsible for localized vulnerability of cerebral ischaemia. This study was aimed to assess the anterior and posterior CA seperately an...
An Ode to DRG Creep
Authors: Jane M. Orient
Journal: Annals of Internal Medicine (1985)

Ad Libitum1 April 1985An Ode to DRG CreepJANE M. ORIENT, M.D.JANE M. ORIENT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-4-565_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo make hospital care most exceedingly fairThere's a new scheme that's called DRG's.The payment for service made Medicare nervous,For lack of control of the fees.Now the pay's by the head, if alive or if dead,Diagnosis determines the money,Giving access to all, at a price that must fall,To assure we can't do it for money.In the state we can trustWith true confidence sure,For they represent us,And their motives are pure,And we know they don't do it for money.To select the right code for each episodeNeeds twelve clerks... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *To the tune of "Oh, a Private Buffoon" from The Yeoman of the Guard by Gilbert & Sullivan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1985Volume 102, Issue 4Page: 565-565KeywordsDiagnosis related groupsFallsMedicare Issue Published: 1 April 1985 PDF downloadLoading ...
後天性血友病Aにおける出血の管理: 欧州後天性血友病(EACH2)登録からの結果
Authors: Baudo Francesco, Collins Peter, Huth-Kuehne Angela, Levesque Herve, Marco Pascual, Nemes Laszlo, Pellegrini Fabio, Tengborn Lilian, Knoebl Paul
Journal: Blood (2012)
Same standards of staffing and equipment should apply in NHS and private sector
Authors: A. Savage
Journal: BMJ (1996)

EDITOR,—I endorse everything that David Currie writes in his personal view about private practice.1 Some 40 years ago I joined a long established practice in north London. “We try not to send patients in privately,” explained one of the partners; “we find too many come out feet first.” Nothing that happened over the subsequent years changed my view. In fact, so convinced am I that …
Abstract P071: The Effect of Menaquinone -7 Supplementation on Circulating Species of Matrix-Gla Protein
Authors: Gerdien W Dalmeijer, Yvonne T van der Schouw, Elke Magdeleyns, Cees Vermeer, Joline W Beulens
Journal: Circulation (2012)

Background: Menaquinones intake is associated with a reduced risk of coronary calcification and coronary heart disease. This association may be explained by increased carboxylation of matrix-Gla protein (MGP) by menaquinones. However, the effect of menaquinone supplementation on MGP carboxylation has not been investigated to date. Objective: To investigate if 180 µg/day and 360 µg/day menaquinone supplementation may increase carboxylation of MGP. Design: A randomized, double-blind, placebo-controlled trial was performed. Sixty subjects aged 40–65 years were randomly allocated to supplementation of 180 μg/d, 360 μg/d of menaquinone-7 (MK-7) or placebo during 12 weeks. At baseline, after 4 and 12 weeks, desphospho-uncarboxylated MGP (dp-ucMGP), desphospho-carboxylated MGP (dp-cMGP) and total uncarboxylated MGP (t-ucMGP) were measured by ELISA techniques. Furthermore, uncarboxylated osteocalcin (ucOC), carboxylated osteocalcin (cOC) and various cardiovascular risk factors were measured. The ratio of ucOC to cOC was used as proxy of vitamin K status. Results: Dp-ucMGP, decreased significantly and dose-dependently in the 180 μg and 360 mg MK-7 supplementation groups ( P time*treatment &lt;0.001) by 31% (400 pM to 276 pM) and 46% (391 pM to 210 pM) respectively after 12 weeks, while dp-ucMGP circulation levels remained unchanged after placebo treatment. The osteocalcin ratio also decreased significantly and dose-dependently in the 180 μg and 360 mg MK-7 treatment ( P time*treatment &lt;0.001) by 57% (0.44 to 0.19) and 74% (0.42 to 0.11) respectively after 12 weeks, while osteocalcin ratio remained unchanged after placebo treatment, showing improved vitamin K status and indicating good compliance to the study treatment. Changes over time of dp-cMGP (p=0.42) and t-ucMGP (p=0.23) levels did not differ between treatment arms. Also the prothrombin time did not differ between treatments arms ( P time*treatment=0.92). Furthermore, changes over time in other risk factors of cardiovascular disease like blood lipid profile or blood pressure did not differ between treatments. Conclusions: Supplementation with MK-7 decreased dp-ucMGP with 31% to 46%. Like the osteocalcin ratio, dp-ucMGP can be used as a sensitive marker of vitamin K status. MK-7 supplementation has no effect on dp-cMGP and t-ucMGP concentrations.
Bidirectional Effect of Interleukin-10 on Early Murine B-Cell Development: Stimulation of flt3-Ligand Plus Interleukin-7–Dependent Generation of CD19− ProB Cells From Uncommitted Bone Marrow Progenitor Cells and Growth Inhibition of CD19+ ProB Cells
Authors: Ole P. Veiby, Ole J. Borge, Annica Mårtensson, Eric X. Beck, Andrew E. Schade, Krzysztof Grzegorzewski, Stewart D. Lyman, Inga-Lill Mårtensson, Sten E.W. Jacobsen
Journal: Blood (1997)
Abstract 2905: Regulation of the Catabolic Ubiquitin-proteasome System in End-stage Chronic Heart Failure: Impact of Physical Exercise Training and Association to Skeletal Muscle Mass
Authors: Sandra Erbs, Robert Hollriegel, Axel Linke, Sven Mobius-Winkler, Stephan Gielen, Volker Adams, Ephraim B Beck, Rainer Hambrecht, Gerhard Schuler
Journal: Circulation (2007)

Exercise intolerance is the key symptom in patients (pts) with chronic heart failure (CHF). This is not only the result of central hemodynamic alterations, but also caused by skeletal muscle wastin...
The computer
Authors: David Isaacs, Stephen Isaacs, Dominic Fitzgerald
Journal: BMJ (2007)

The main purpose of a computer is domination. A computer ensures you do not waste your time seeing patients—or waste your time on other unimportant pursuits such as eating, drinking, sleeping, or making babies.

A subsidiary purpose of a computer is to provide a mini-mental test of your capacity to remember passwords. Passwords on a computer are different for every program, and change as frequently as you change your underwear. Passwords are the name of your deceased dog, or your partner’s name spelt backwards, followed by a number that increases exponentially. If you are able to remember all your passwords, you have Asperger’s syndrome and should see a doctor immediately. Normal human beings keep their passwords safely hidden on a piece of scrap paper, never to be found again.

Theoretically, computers save trees, except that everyone prints out their electronic documents to read offline, thereby avoiding terminal migraine.

A desktop computer is like a dominatrix. It has everything you want and more, but is determined to demonstrate your inadequacy and your total dependence. The computer knows your patients’ laboratory results, so you need never see your patients again. An endless torrent of emails will keep you hostage for hours. Your colleagues are under the delusion that their emails have direct access to your brain, and telephone grumpily if you do not reply within seconds. The emails you do open invariably impugn the size or function of a man’s private parts or offer breast enlargement. The computer is programmed to send an email every time you attempt to leave the office, the number of attachments directly proportional to the urgency of the appointment you are missing.

Modern life is about portability and practicality, as you negotiate the declining distinction between work and home life. Mobility is the order of the day—mobile phones, mobile homes, and mobile morals. The solution is a laptop computer. A laptop is like a lapdog but with a brain. It requires a licence and regular nourishment, but will then act as a CAD (conversation avoidance device). A laptop is part of the dress code for all government employees you’re likely to encounter and is an essential accessory for aeroplane travel. You will, however, need the coordination of an Olympic gymnast to work the mouse, and the patience of Job when the battery runs out halfway through your flight and loses all your work.
Chromatographic Studies on the Separation of the Virus from Chicken Tumor I. II. Zoning, Purification, and Recovery of the Agent from the Column<xref ref-type="fn" rid="fn1"><sup>2</sup></xref>
Authors: Vernon Riley
Journal: JNCI Journal of the National Cancer Institute (1950)

Chromatographic Studies on the Separation of the Virus from Chicken Tumor I. II. Zoning, Purification, and Recovery of the Agent from the Column Get access Vernon Riley Vernon Riley National Cancer Institute, National Institutes of Health, U. S. Public Health Service, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 11, Issue 1, August 1950, Pages 215–227, https://doi.org/10.1093/jnci/11.1.215 Published: 01 August 1950 Article history Received: 15 March 1950 Published: 01 August 1950
Implantation of fibroblasts transfected with human granulocyte colony- stimulating factor cDNA into mice as a model of cytokine-supplement gene therapy
Authors: K Tani, K Ozawa, H Ogura, T Takahashi, A Okano, K Watari, T Matsudaira, K Tajika, H Karasuyama, S Nagata
Journal: Blood (1989)
Explaining about possible adverse events may reduce problems
Authors: R. Behrens
Journal: BMJ (1996)

Table 1-Comparison of results of study by Barrett and colleagues and study by Phillips and Kass.2Figures are numbers (percentages) of subjects except where stated otherwise Barrett and Phillips colleagues and Kass Total taking mefloquine 1214 285 Women taking mefloquine 698 (57) 171 (60) Median duration of use (weeks) 7 6 Adverse effects (all grades) occurred 503 (41) 108 (38) Events interfered with daily activities 143 (12) 32 (11) Stopped taking drug owing to adverse effects 63 (5) 18 (6)were admitted to hospital; the third had a seizure.Our study also found that basic travel, as opposed to group travel itself, was a major posi- tive effect modifying variable for adverse events associated with mefloquine.If this useful drug is not to be abandoned pre- maturely, prescribers must be given guidance about the pharmacology of mefloquine in women and possible interactions with recrea- tional drugs.We fully inform potential meflo- quine users about these issues and, when possible, give people two or three doses as a trial before they leave Australia.Initial poor tolerance of mefloquine can be greatly improved by altering the regimen to half a tablet twice weekly, although this has yet to be verified scientifically.
N0436: A phase II trial of irinotecan plus cetuximab in patients with metastatic breast cancer and prior anthracycline and/or taxane-containing therapy
Authors: T. J. Hobday, P. J. Stella, T. R. Fitch, A. Jaslowski, B. LaPlant, M. M. Ames, M. P. Goetz, E. A. Perez
Journal: Journal of Clinical Oncology (2008)

1081 Background: Irinotecan has a 23% response rate (RR) in patients (pts) with previously treated metastatic breast cancer (MBC) (Perez, JCO 2004). Epidermal growth factor receptor (EGFR) is overexpressed in MBC, especially in those with ER-/PR- and HER2-negative tumors (triple-negative, [TNeg]). Cetuximab is a monoclonal antibody against EGFR with additive activity to irinotecan in colorectal cancer with acceptable toxicity. Methods: This one-stage phase II study enrolled pts with MBC, measurable disease, and prior anthracycline and/or taxane therapy. Pts received cetuximab 400 mg/m2 day 1 cycle 1 then 250 mg/m2 weekly and irinotecan 80 mg/m2 days 1, 8 of each 21-day cycle. Primary endpoint was confirmed RR by RECIST criteria. Planned sample size was 36. Genotyping for UGT1A1 polymorphisms was performed. Results: 19 eligible pts enrolled from 2/06 to 9/06 with a median age of 49 yrs (range: 28–76), 74% had visceral disease, 32% were ER and/or PR positive, 11% were HER2 positive, 58% were TNeg. 79% had prior chemotherapy for MBC. Pts received a median of 2 cycles (range: 1–11) of treatment. Confirmed RR was 11% (95% CI: 1–33%), with 1 PR and 1 CR. One pt had stable disease for 11 cycles. RR and clinical benefit rate (CBR: RR + stable > 6 months) for Tneg vs non- Tneg was 18% vs 0% (p=0.49) and 27% vs 0% (p=0.23). 12 pts progressed on therapy within 2 cycles. With low response rate and rapid progression, the study closed early. NCI CTC version 3 grade 3–4 adverse events occurred in 10 pts; only dermatologic toxicity (derm tox) had a > 5% incidence (26%). Patients with grade ≥ 2 derm tox had a CBR of 21% (3/14) vs 0% in patients with grade 0–1. 18 pts have progressed with a median time to progression of 1.4 mos (95% CI: 1.1–2.2 mos). 15 pts have died with a median overall survival of 9.4 mos (95% CI: 3.3–16.1 mos). UGT1A1 results will be presented. Conclusions: Irinotecan and cetuximab has minimal activity in this population. Tolerability is acceptable. There was a numerically higher CBR in Tneg pts and patients with grade ≥ 2 derm tox, but small pt numbers limit conclusions. Better predictive factors for response to EGFR inhibition are needed. NCI CA-25224, CA-63848, CA-37404, CA- 60276, Bristol-Myers Squibb, Imclone systems Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Bristol-Myers Squibb
Cases of community-acquired meticillin-resistant Staphylococcus aureus in an asylum seekers centre in Germany, November 2010
Authors: S Dudareva, A Barth, K Paeth, A Krenz-Weinreich, F Layer, Y Deleré, T Eckmanns
Journal: Eurosurveillance (2011)

In an asylum seeker centre in Schleswig-Holstein, a resident was diagnosed with furuncle caused by a Panton-Valentine leukocidine (PVL)-positive community-acquired meticillin-resistant Staphylococcus aureus (CA-MRSA). As a result of active case finding, 232 of 427 persons (54% of all residents) were screened for MRSA and two further PVL-positive CA-MRSA cases were identified.
Abstract 220: Development of a Supraglottic Airway Device with the Function of Pharyngeal Cooling
Authors: Yoshimasa Takeda, Hiroshi Hashimoto, Ryoichi Mizoue, Sachiko Sato, Hiroshi Morimatsu
Journal: Circulation (2013)

Introduction: Intra-ischemic brain hypothermia has shown better neuroprotective effects when it is initiated earlier after the onset of resuscitation. To initiate brain hypothermia simultaneously with airway management at the beginning of resuscitation, we developed a supraglottic airway device that enables initiation of pharyngeal cooling. The effects of the airway device on brain temperature were evaluated. Methods: A Japanese monkey (10 kg) was anesthetized with isoflurane. The airway was maintained with our newly developed supraglottic airway device. Artificial ventilation was performed with tidal volume = 100 ml, respiratory rate = 20±5 times /min and peak airway pressure &lt; 20 cmH2O. PaCO2 was maintained at 40±5 mmHg. Right epidural temperature (parietal cortex), right sub-cortical temperature (3 cm below the cortical surface) and rectal temperature were monitored. A pharyngeal cooling cuff attached under the supraglottic airway device was perfused with physiological saline (5 °C) at the rate of 500 ml/min for 60 min. Intracuff pressure was maintained &lt; 50 cmH2O. Result: Initiation of pharyngeal cooling did not affect respiratory conditions, including peak airway pressure and PaCO2. Epidural temperature had decreased by 3.1 °C and 4.7°C at 30 min and 60 min after the onset of cooling, respectively. Sub-cortical temperature had decreased by 2.7°C and 4.2 °C at 30 min and 60 min after the onset of cooling, respectively. Rectal temperature had decreased by 1.9 °C and 3.2 °C at 30 min and 60 min after the onset of cooling, respectively. Conclusion: The supraglottic airway device with the function of pharyngeal cooling can reduce the onset time for initiation of brain cooling.
Abstract 10131: Does the Type and Dose of Palliative Care Services Received by Patients With Advanced Heart Failure Impact Symptom Burden?
Authors: Lorraine S Evangelista, Jennifer Ballard-Hernandez, Dawn Lombardo, Shaista Malik, Marjan Motie, Solomon Liao
Journal: Circulation (2013)

Introduction: Outpatient palliative care (PC) for patients with symptomatic heart failure (HF) is a relatively new practice and few data exist that describe the nature of these clinical encounters. HYPOTHESIS: We hypothesized that the nature of outpatient PC services (i.e. type, duration, frequency) used by patients with advanced HF would impact symptom burden 3 months post-discharge. METHODS: This study was conducted at a single, tertiary care medical center. Patients were recruited from the inpatient setting during an episode of acute HF exacerbation and referred for an initial PC consultation and subsequent follow-up support with the PC team. Data on PC services accessed were monitored over 3 months. Telephone surveys were conducted immediately after and 3 months post-discharge to assess symptom burden. Results: Thirty six patients completed the initial PC consultation with a PC specialist (17%) or advanced practice nurse (83%); care focused on physical and psychosocial assessment (100%), advanced care...