tbuckley/cabot-search huggingface dataset:
Author's Response
Authors: Patricia M. Greenfield
Journal: Behavioral and Brain Sciences (2002)

Ronan Reilly's connectionist simulation both strengthens and advances the theoretical model presented in my 1991 target article, “Language, Tools, and Brain: The Ontogeny and Phylogeny of Hierarchically Organized Sequential Behavior.” Reilly has tested the whole ontogenetic model with a single simulation study explicitly planned for this purpose. His methodology has established that the various components of the theoretical model imply and are compatible with one another. It has also indicated how learning can actualize a pre-established ontogenetic sequence of combining lingusitic symbols and objects. His simulation suggests that the acquisition of linguistic speech may be facilitated by experience with object manipulation, but not vice versa. This hypothesis can and should be empirically tested through research on behavioral development in the two domains. Finally, Reilly has simulated brain architecture, as well as neural learning. His simulation therefore shows how the development of language and object manipulation can result from an interaction between preprogrammed neural architecture (analogous to network architecture) and experience (analogous to the network's training cycles).
Engineered platelets-based drug delivery platform for targeted thrombolysis
Authors: Songli Wang, Ruifeng Wang, Nana Meng, Linwei Lu, Jun Wang, Jianfen Zhou, Jiasheng Lu, Qianzhu Xu, Cao Xie, Changyou Zhan, Yao Li, Yang Yu, Weiyue Lu, Min Liu
Journal: Acta Pharmaceutica Sinica B (2022)

Thrombolytic agents have thus far yielded limited therapeutic benefits in the treatment of thrombotic disease due to their short half-life, low targeting ability, and association with serious adverse reactions, such as bleeding complications. Inspired by the natural roles of platelets during thrombus formation, we fabricated a platelet-based delivery system (NO@uPA/PLTs) comprising urokinase (uPA) and arginine (Arg) for targeted thrombolysis and inhibition of re-embolism. The anchoring of uPA to the platelet surface by lipid insertion increased the thrombotic targeting and in vivo circulation duration of uPA without disturbing platelet functions. Nitric oxide (NO) generated by the loaded Arg inhibited platelet aggregation and activation at the damaged blood vessel, thereby inhibiting re-embolism. NO@uPA/PLTs effectively accumulated at the thrombi in pulmonary embolism and carotid artery thrombosis model mice and exerted superior thrombolytic efficacy. In addition, the platelet delivery system showed excellent thrombus recurrence prevention ability in a mouse model of secondary carotid artery injury. The coagulation indicators in vivo showed that the platelet-based uPA and NO co-delivery system possessed a low hemorrhagic risk, providing a promising tool for rapid thrombolysis and efficient inhibition of posttreatment re-embolism.
The Propaganda for Reform
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Therapeutic angiogenesis by bone marrow-derived cell transplantation in pigs with coronary constrictor-induced chronic myocardial ischemia Takafumi Ueno, Patrick K. Coussement, Toyoaki Murohara, Jianhua Cui, Payam Fallahi, Mika Ueno, Stephen Frohwein, Samuel Baldwin, Maria Palasis, Tsutomu Imaizumi, Nicolas AF Chronos, Keith A. Robinson. Atlanta Cardiovascular Research Institute, Norcross, GA, Kurume University School of Medicine, Kurume, Japan
Journal: Journal of the American College of Cardiology (2001)
Current Medical Literature
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
circFARP1 enables cancer-associated fibroblasts to promote gemcitabine resistance in pancreatic cancer via the LIF/STAT3 axis
Authors: Chonghui Hu, Renpeng Xia, Xiang Zhang, Tingting Li, Yuancheng Ye, Guolin Li, Rihua He, Zhihua Li, Qing Lin, Shangyou Zheng, Rufu Chen
Journal: Molecular Cancer (2022)

Cancer-associated fibroblasts (CAFs) are critically involved in gemcitabine (GEM) resistance in pancreatic ductal adenocarcinoma (PDAC). However, the underlying mechanism by which CAFs promote chemotherapy resistance remains unexplored. Here, we explored the role of circRNAs in CAF-induced GEM resistance in PDAC. circRNA sequencing and quantitative real-time PCR (qRT-PCR) were utilized to screen CAF-specific circRNAs. The effects of CAF circFARP1 expression on GEM resistance in tumor cells were assessed in vitro and in vivo. RNA-seq, RNA pulldown, RNA immunoprecipitation, and luciferase reporter assays were used to screen the downstream target and underlying mechanism of circFARP1. circFARP1 (hsa_circ_0002557), a CAF-specific circRNA, was positively correlated with GEM chemoresistance and poor survival in an advanced PDAC cohort. Silencing or overexpressing circFARP1 in CAFs altered the ability of CAFs to induce tumor cell stemness and GEM resistance via leukemia inhibitory factor (LIF). Mechanistically, we found that circFARP1 directly binds with caveolin 1 (CAV1) and blocks the interaction of CAV1 and the E3 ubiquitin-protein ligase zinc and ring finger 1 (ZNRF1) to inhibit CAV1 degradation, which enhances LIF secretion. In addition, circFARP1 upregulated LIF expression by sponging miR-660-3p. Moreover, high circFARP1 levels were positively correlated with elevated serum LIF levels in PDAC and poor patient survival. Decreasing circFARP1 levels and neutralizing LIF significantly suppressed PDAC growth and GEM resistance in patient-derived xenograft models. The circFARP1/CAV1/miR-660-3p/LIF axis is critical for CAF-induced GEM resistance in PDAC. Hence, circFARP1 may be a potential therapeutic target for PDAC.
Influence of loading conditions on physical determinants of aortic regurgitant flow volume and severity: A chronic animal experiment Hiroyuki Tsujino, Michael Jones, Takahiro Shiota, YongJin Kim, Fabrice Bauer, Jian Xin Qin, Marta Sitges, Lisa A. Cardon, Arthur D. Zetts, James D. Thomas. The Cleveland Clinic Foundation, Cleveland, OH, The National Institutes of Health, Bethesda, MD
Journal: Journal of the American College of Cardiology (2001)
Lung function during and after acute respiratory infection in COVID-19 positive and negative outpatients
Authors: Pekka Tamminen, Dominik Kerimov, Hanna Viskari, Janne Aittoniemi, Jaana Syrjänen, Lauri Lehtimäki
Journal: European Respiratory Journal (2022)

<b>At acute phase, outpatients with mild COVID-19 had more symptoms, higher small airway resistance and poorer lung elasticity compared to outpatients with other respiratory infections, but there was no difference between the groups after 2 months</b>https://bit.ly/3nalPye
Alcohol Industry Isn’t Adhering to Limit on Youth Advertising
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 923: Flatline - A Novel Transcriptional Regulator Controls Myofibrillogenesis
Authors: Steffen Just, Nicole Trano, Benjamin Meder, Mark C Fishman, Wolfgang Rottbauer
Journal: Circulation (2006)

Coordinate renewal of sarcomeric units is essential to all muscle tissue. However, gene programs that regulate cardiac and skeletal muscle myofibrillogenesis are only poorly understood, but of grea...
Summaries of Key Journal Articles
Authors: Kim A. Eagle, Christopher P. Cannon, William F. Armstrong, David S. Bach, Ragavendra R. Baliga, Timothy B. Cotts, Jennifer Cowger, Daniel T. Eitzman, James B. Froehlich, Caren S. Goldberg, Hitinder S. Gurm, Jennifer C. Hirsch, Elizabeth Anne Jackson, Fred Morady, Debabrata Mukherjee, Himanshu J. Patel, Melvyn Rubenfire, Gilbert R. Upchurch
Journal: Journal of the American College of Cardiology (2010)
Corrigendum
Journal: British Journal of Dermatology (2019)

In the article by Yiu et al, on page 331 it states that 844 patients were not included; three emigrated, 785 withdrew consent and 56 did not complete their questionnaire.Similarly, on page 335 it states that a total of 844 registered patients were classified as dropping out owing to lack of follow-up.Of these patients, 92Á5% (785 patients) discontinued the study owing to withdrawal of consent.The correct reasons are 80.7% (681 patients) had not reached their first follow-up, 15.7% (133 patients) did not attend their follow-up clinics, and 3.6% (30 patients) moved to an unknown area or hospital or withdrew consent.The authors apologise for the error.
Author Correction: A global approach to improving penile cancer care
Authors: Marco Bandini, Mohamed Ahmed, Giuseppe Basile, Nicholas Watkin, Viraj Master, Yao Zhu, Gagan Prakash, Alejandro Rodriguez, Mbaaga K. Ssebakumba, Riccardo Leni, Giuseppe Ottone Cirulli, Ben Ayres, Rachel Compitello, Filippo Pederzoli, Pankaj M. Joshi, Sanjay B. Kulkarni, Francesco Montorsi, Guru Sonpavde, Andrea Necchi, Philippe E. Spiess
Journal: Nature Reviews Urology (2022)
Will the COVID-19 pandemic threaten the SDGs?
Authors: None The Lancet Public Health
Journal: The Lancet Public Health (2020)

The UN's Sustainable Development Goals (SDGs), adopted in 2015, provide an international framework to move by 2030 toward more equitable, peaceful, resilient, and prosperous societies—while living within sustainable planetary boundaries. As the UN celebrates its 75th anniversary and a third of the SDG timeline has passed, The Sustainable Development Goals Report 2020—prepared by the UN Department of Economic and Social Affairs in collaboration with experts and international agencies— tells a story of tentative but insufficient progress, and warns of the regressive impact of the coronavirus pandemic.
Sunken Nose
Authors: Reza Zonozi, John L. Niles
Journal: New England Journal of Medicine (2021)

A 34-year-old woman presented with rhinorrhea, bloody nasal crusting, and nasal deformity that had progressed over a period of 7 years. Physical examination revealed complete collapse of the nasal bridge and retraction of the tip of the nose, and a diagnosis of granulomatosis with polyangiitis was made.
Viral bronchiolitis
Authors: Todd A Florin, Amy C Plint, Joseph J Zorc
Journal: The Lancet (2016)

Viral bronchiolitis is a common clinical syndrome affecting infants and young children. Concern about its associated morbidity and cost has led to a large body of research that has been summarised in systematic reviews and integrated into clinical practice guidelines in several countries. The evidence and guideline recommendations consistently support a clinical diagnosis with the limited role for diagnostic testing for children presenting with the typical clinical syndrome of viral upper respiratory infection progressing to the lower respiratory tract. Management is largely supportive, focusing on maintaining oxygenation and hydration of the patient. Evidence suggests no benefit from bronchodilator or corticosteroid use in infants with a first episode of bronchiolitis. Evidence for other treatments such as hypertonic saline is evolving but not clearly defined yet. For infants with severe disease, the insufficient available data suggest a role for high-flow nasal cannula and continuous positive airway pressure use in a monitored setting to prevent respiratory failure.
Differences in his to atrial interval in atrioventricular nodal reentrant tachycardia: Distinction among tachycardia subtypes and relationship to heart block with catheter ablation Gregory T. Altemose, John V. Jayachandran, Douglas P. Zipes, John M. Miller. Indiana University School of Medicine, Krannert Institute of Cardiology, Indianapolis, IN
Journal: Journal of the American College of Cardiology (2001)
Travel-associated Legionnaires’ disease in Europe in 2008
Authors: K Ricketts, C A Joseph, R Yadav, Collective on behalf of the European Working G
Journal: Eurosurveillance (2010)

In 2008, the European Surveillance Scheme for Travel Associated Legionnaires’ Disease (EWGLINET) received reports of 866 cases of travel-associated Legionnaires’ disease, 42 of whom were reported to have died. 824 of the cases were classified as confirmed and 42 were presumptive. As in previous years, a very low proportion of clinical isolates were obtained (63 cases, 7.3%). Males outnumbered females by 2.8:1 in the 2008 dataset and had a median age of 60 years compared with women, whose median age was 63 years. Travel outside Europe was reported for 12% of the cases. The scheme identified 108 new clusters in 2008. Sixteen were located in countries outside EWGLINET and 38 (35.2%) involved only one case from each reporting country, and would not ordinarily have been detected by national surveillance schemes alone. The largest cluster (six cases) was associated with travel to Spain. The 108 clusters were associated with 144 environmental investigations, 35 of which were at re-offending sites, (sites which had previously been investigated and where additional cases had subsequently occurred). At 61 (42.1%) of the sites Legionella species were detected. The names of 12 sites were published on the EWGLINET website.
Introduction to Public Health Surveillance Course
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Impact of the COVID-19 pandemic on gastrointestinal endoscopy in the Netherlands: analysis of a prospective endoscopy database
Authors: Marten A. Lantinga, Felix Theunissen, Pieter C. J. ter Borg, Marco J. Bruno, Rob J. T. Ouwendijk, Peter D. Siersema
Journal: Endoscopy (2021)

Correction to: Impact of the COVID-19 pandemic on gastrointestinal endoscopy in the Netherlands: analysis of a prospective endoscopy databaseEndoscopy 2021; 53(02): 166-170DOI: 10.1055/a-1272-3788
Elevated C-reactive protein and increasing severity of coronary artery disease: Independent or interdependent predictors of risk? James S. Zebrack, Joseph B. Muhlestein, Benjamin D. Horne, Tami L. Bair, Dale G. Renlund, Jeffrey L. Anderson. University of Utah, Salt Lake City, UT, LDS Hospital, Salt Lake City, UT
Journal: Journal of the American College of Cardiology (2001)
MISCELLANY.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Survival after implantation of an implantabe cardioverter-defibrillator in elderly patients Emmanouil S. Brilakis, Arturo Valverde, David Luria, Yong-Mei Cha, Chris Scott, Robert Rea, Paul A. Friedman, Win K. Shen. Mayo Clinic, Rochester, MN
Journal: Journal of the American College of Cardiology (2001)
Use of different catheter ablation technologies for typical atrial flutter: Acute results and follow-up Robert Schweikert, Andrea Natale, Mina K. Chung, Patrick Tchou, Walid Saliba, Lon Castle, Logan Kanagaratnam, Mark Niebauer, Stephen Pavia, Cathy Lam, Alejandro Perez-Lugones. Cleveland Clinic Foundation, Cleveland
Journal: Journal of the American College of Cardiology (2001)
Health concerns in long-term survivors with ovarian cancer: Results of Expression VI–Carolin meets HANNA–Holistic Analysis of Long-term survival with Ovarian Cancer—The international NOGGO, ENGOT and GCIG survey.
Authors: Hannah Woopen, Maren Keller, Ioana Braicu, Dario Zocholl, Joanna Baum, Petra Krabisch, Tamara Boxler, Pauline Wimberger, Catarina Madroñal, Marta Gil-Martin, Vesna Bjelic-Radisic, Sinisha Trpchevski, Eleftherios Pierre Samartzis, Viola A. Heinzelmann-Schwarz, Patriciu Achimaș-Cadariu, Paul Kubelac, Mehmet Ali Vardar, Marcin Andrzej Jedryka, Ignace Vergote, Jalid Sehouli
Journal: Journal of Clinical Oncology (2021)

12023 Background: So-called long-term survivors (LTS) may be cured from cancer but still experience a wide range of long-term side effects. Aim was to analyze the main concerns in long-term survival to improve follow-up care. Methods: Within the study “Carolin meets HANNA” (www.carolinmeetshanna.com) long-term survivors with ovarian cancer (LTS) were recruited since 11/2016. Long-term survival was defined as an ovarian cancer diagnosis more than five years ago. Results: Until 02/2021 1,044 long-term survivors with ovarian cancer could be recruited. Median survival time at recruitment was 11 years (range 5-43 years). More than half had been diagnosed with advanced stage ovarian cancer (58.6% FIGO III/IV). Almost half have developed recurrent disease (43.4%). 26.0% were under cancer treatment at recruitment. Health status was rated very good or good by 52.0% while 20.3% report a bad or very bad health status. Almost half of the LTS have current concerns/long-term side effects (46.1%). Main concerns are fatigue (23.9%), pain (21.6%), polyneuropathy (16.9%), gastrointestinal symptoms (16.6%) and memory problems (15.5%). 42.8% still regard themselves as cancer patients. Health status and distress did not differ between LTS 5-10 years after diagnosis and &gt; 10 years after diagnosis (p = 0.59 and p = 0.0843 respectively). Patients with a history of recurrence and those under current treatment had a worse health status and more health concerns. LTS without recurrence reported fatigue in 18.4%, pain in 19.2%, polyneuropathy in 13.1%, gastrointestinal problems in 13.4% and memory problems in 14.4%. Fatigue, polyneuropathy, nausea and concentration problems improve with the time of survival. However, fatigue is still present in 21.1% after ten years survival time. There was no significant difference in pain between 5-10 (20.1%) and &gt; 10 years (22.0%) survival time. In this cohort 94.2% receive regular follow-up care including CA125 testing in 77.0%, clinical examination in 54.3%, transvaginal ultrasound in 55.1%, abdominal ultrasound in 43.9%, mammogram in 50.5% and further radiological examinations such as CT scans in 53.4%. Conclusions: Follow-up care in ovarian cancer is usually delivered within the first five years after diagnosis. However, our analyses show the high frequency of health concerns in LTS despite the high frequency of follow-up care in this cohort. Therefore, specialized survivorship care should be offered beyond the typical five years of follow-up care with a focus on long-term side effects.
Book Review What People Are: A study of normal young men. By Clark W. Heath, M.D. In collaboration with Lucien Brouha, Ph.D., Lewise W. Gregory, Carl C. Seltzer, Ph.D., Frederic L. Wells, Ph.D., and William L. Woods, Ph.D. A publication of the Department of Hygiene, Harvard University, under a grant from the Grant Foundation. 8°, cloth, 141 pp., with 7 tables. Cambridge: Harvard University Press, 1945. $2.00.
Journal: New England Journal of Medicine (1946)