tbuckley/cabot-search huggingface dataset:
IMPACT OF CANNABIS USE ON ADMISSIONS AND OUTCOMES OF PULMONARY CIRCULATION DISORDERS: A NATIONAL INPATIENT SAMPLE ANALYSIS
Authors: Zainab Gandhi, Akhil Jain, Sonali Sachdeva, Shubham Adroja, Ankit Vyas, Sandeep Singh, Rupak Desai
Journal: Journal of the American College of Cardiology (2021)
DRUGS, BUGS AND THE ECMO UNPLUGGED: A CASE OF A 61-YEAR-OLD WITH CARDIOGENIC SHOCK AND UTILITY OF PALLIATIVE BEDSIDE ECMO DE-ESCALATION
Authors: Kathleen Kopecky, Christo Mathew, Timothy Gong, Dan Enter, Mojahed Shalabi, Britton Blough, Amit Alam, Shelley Hall
Journal: Journal of the American College of Cardiology (2021)
通常検討パラメータの組み合わせは,トランスサイレチン心アミロイドーシス疑い高齢患者における陽性 99m Tc標識ピロリン酸シンチグラフィー所見の有用な予測因子である
Authors: Marume Kyohei, Takashio Seiji, Nishi Masato, Hirakawa Kyoko, Yamamoto Masahiro, Hanatani Shinsuke, Oda Seitaro, Utsunomiya Daisuke, Shiraishi Shinya, Ueda Mitsuharu, Yamashita Taro, Sakamoto Kenji, Yamamoto Eiichiro, Kaikita Koichi, Izumiya Yasuhiro, Yamashita Yasuyuki, Ando Yukio, Tsujita Kenichi
Journal: Circulation (2019)
Seroprevalence of SARS-CoV-2 antibodies in university students: Cross-sectional study, December 2020, England
Authors: Amoolya Vusirikala, Heather Whitaker, Samuel Jones, Elise Tessier, Ray Borrow, Ezra Linley, Katja Hoschler, Frances Baawuah, Shazaad Ahmad, Nick Andrews, Mary Ramsay, Shamez N Ladhani, Kevin E Brown, Gayatri Amirthalingam
Journal: Journal of Infection (2021)
Spiral stent placement for bile leakage after hepatobiliary surgery
Authors: Yunosuke Takishin, Masaki Kuwatani, Naoya Sakamoto
Journal: Endoscopy (2021)

Endoscopic drainage, especially endoscopic nasobiliary drainage (ENBD) followed by stent placement, is recommended for bile leakage after hepatobiliary surgery [1] [2] [3]. However, these stents can sometimes migrate, depending on the ability of the stent to conform to the bile duct postoperatively. To solve this problem, we used a unique plastic stent (Spiral-K, Gadelius Medical K.K., Tokyo, Japan) ([Fig. 1 a]) placed above the papilla. Originally, the spiral end was placed proximally and the pigtail end was placed distally. We shortened the pigtail end and placed the stent upside down such that the spiral end was positioned distally ([Fig. 1 b]).
IMPACT OF INCREASING LEFT VENTRICULAR SIZE ON ACCURACY OF ECHOCARDIOGRAPHIC MEASUREMENTS OF LV REMODELING IN PATIENTS WITH ISCHEMIC CARDIOMYOPATHY
Authors: Ramya Vajapey, Nancy Obuchowski, Zoran Popovic, Brian Griffin, Wilson Tang, Scott Flamm, Deborah Kwon
Journal: Journal of the American College of Cardiology (2021)
SEMAGLUTIDE REDUCES HIGH-SENSITIVITY CRP LEVELS ACROSS DIFFERENT TREATMENT FORMULATIONS: EXPLORATORY ANALYSES OF SUSTAIN 3 AND PIONEER 1, 2 AND 5 TRIALS
Authors: Julio Rosenstock, Matthew Capehorn, Alessandra De Remigis, Søren Rasmussen, Petra Weimers, Ofri Mosenzon
Journal: Journal of the American College of Cardiology (2021)
INFLUENCE OF CORONARY ARTERY DISEASE AND PERCUTANEOUS CORONARY INTERVENTION ON MID-TERM OUTCOMES IN PATIENTS WITH AORTIC VALVE STENOSIS TREATED WITH TRANSCATHETER AORTIC VALVE IMPLANTATION
Authors: Toshiki Kaihara, Takumi Higuma, Masaki Izumo, Nozomi Kotoku, Tomomi Suzuki, Haruka Kameshima, Yukio Sato, Shingo Kuwata, Masashi Koga, Takanobu Mitarai, Mika Watanabe, Kazuaki Okuyama, Ryo Kamijima, Yuki Ishibashi, Kihei Yoneyama, Yasuhiro Tanabe, Tomoo Harada, Yoshihiro Akashi
Journal: Journal of the American College of Cardiology (2021)
SEX DIFFERENCES IN DISTRIBUTION, MANAGEMENT AND OUTCOMES OF COMBINED ISCHEMIC-BLEEDING RISK FOLLOWING ACUTE CORONARY SYNDROME
Authors: Mohamed Mohamed, Muhammad Rashid, Adam Timmis, Sarah Clarke, Erin Michos, Chun Shing Kwok, Mark de Belder, Marco Valgimigli, Mamas Mamas
Journal: Journal of the American College of Cardiology (2021)
PRE-EXISTING ATRIAL FIBRILLATION OR FLUTTER IN PATIENTS WITH ELECTRICAL STORM HAS NO IMPACT ON IN-HOSPITAL OR ONE-YEAR MORTALITY
Authors: Cameron Incognito, Joshua Parker, Jeffrey Hedley, Alex Milinovich, Venu Menon, Oussama Wazni, John Rickard, Wai Hong Tang
Journal: Journal of the American College of Cardiology (2021)
CLINICAL SIGNIFICANCE OF THE HEMODYNAMIC GAIN INDEX IN PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION UNDERGOING CARDIOPULMONARY EXERCISE TESTING
Authors: Thanat Chaikijurajai, Yuping Wu, Timtothy Engelman, Vicente Morales Oyarvide, Jose Emanuel Finet, Justin Grodin, Wai Hong Tang
Journal: Journal of the American College of Cardiology (2021)
REMOTE ECG MONITORING TO REDUCE COMPLICATIONS FOLLOWING TRANSCATHETER AORTIC VALVE IMPLANTATIONS - THE REDIRECT TAVI STUDY
Authors: Madhu K. Natarajan, Tej Sheth, Harindra Wijeysundera, James Velianou, Toni Newman, Josep Rodes-Cabau, Amanda Smith, Jorge Wong, Jon-David Schwalm, Jeff Healey
Journal: Journal of the American College of Cardiology (2021)
TORN AORTIC VALVE - A RARE CASE OF AORTIC VALVE CUSP RUPTURE DURING PRE TAVR BALLOON VALVULOPLASTY WITH SUBSEQUENT LEFT MAIN CORONARY OBSTRUCTION, IN A PATIENT WITH MEDIASTINAL RADIATION EXPOSURE
Authors: Akarsh Parekh, Vivek Sengupta, Victor Hunyadi, Melissa Ianitelli, Mark Zainea
Journal: Journal of the American College of Cardiology (2021)
Author Correction: Identification of a new orthonairovirus associated with human febrile illness in China
Authors: Jun Ma, Xiao-Long Lv, Xu Zhang, Shu-Zheng Han, Ze-Dong Wang, Liang Li, He-Ting Sun, Li-Xin Ma, Zheng-Lei Cheng, Jian-Wei Shao, Chen Chen, Ying-Hua Zhao, Liyan Sui, Lin-Na Liu, Jun Qian, Wei Wang, Quan Liu
Journal: Nature Medicine (2021)
Culture Substrates for Improved Manufacture of Mesenchymal Stromal Cell Therapies
Authors: Gilad Doron, Johnna S. Temenoff
Journal: Advanced Healthcare Materials (2021)

Recent developments in mesenchymal stromal cell (MSC) therapies have increased the demand for tools to improve their manufacture, including the selection of optimal culture substrate materials. While many clinical manufacturers use planar tissue culture plastic (TCP) surfaces for MSC production, others have begun exploring the use of alternative culture substrates that present a variety of spatial, mechanical, and biochemical cues that influence cell expansion and resulting cell quality. In this review, the effects of culture and material properties distinct from traditional planar TCP surfaces on MSC proliferation, surface marker expression, and commonly used indications for therapeutic potency are examined. The different properties summarized include the use of alternative culture formats such as cellular aggregates or 3D scaffolds, as well as the effects of culture substrate stiffness and presentation of specific adhesive ligands and topographical cues. Specific substrate properties can be related to greater cell expansion and improvement in specific therapeutic functionalities, demonstrating the utility of culture materials in further improving the clinical-scale manufacture of highly secretory MSC products.
ASSESSMENT OF INTERVENTIONAL CARDIOLOGY FELLOWS’ ABILITIES IN INTRACORONARY PHYSIOLOGY AND IMAGING
Authors: Muhammed Rahim, Hussein Rahim, Shawn Gogia, Denizhan Ozdemir, Erin Flattery, Sahil Parikh, Ajay Kirtane, Tamim Nazif, Torsten Vahl, Dimitrios Karmpaliotis, Ori Ben-Yehuda, Allen Jeremias, Evan Shlofmitz, Richard Shlofmitz, Khady Fall, Mitsuaki Matsumura, Bjorn Redfors, Jeffrey Moses, Gregg Stone, Akiko Maehara, Martin Leon, Sunil Rao, Ehtisham Mahmud, Gary Mintz, Ziad Ali
Journal: Journal of the American College of Cardiology (2021)
Short Diagnosis-to-Treatment Interval Is Associated With Higher Circulating Tumor DNA Levels in Diffuse Large B-Cell Lymphoma
Authors: Stefan Alig, Charles W. Macaulay, David M. Kurtz, Ulrich Dührsen, Andreas Hüttmann, Christine Schmitz, Michael C. Jin, Brian J. Sworder, Andrea Garofalo, Mohammad Shahrokh Esfahani, Barzin Y. Nabet, Joanne Soo, Florian Scherer, Alexander F. M. Craig, Olivier Casasnovas, Jason R. Westin, Gianluca Gaidano, Davide Rossi, Mark Roschewski, Wyndham H. Wilson, Michel Meignan, Maximilian Diehn, Ash A. Alizadeh
Journal: Journal of Clinical Oncology (2021)

Patients with Diffuse Large B-cell Lymphoma (DLBCL) in need of immediate therapy are largely under-represented in clinical trials. The diagnosis-to-treatment interval (DTI) has recently been described as a metric to quantify such patient selection bias, with short DTI being associated with adverse risk factors and inferior outcomes. Here, we characterized the relationships between DTI, circulating tumor DNA (ctDNA), conventional risk factors, and clinical outcomes, with the goal of defining objective disease metrics contributing to selection bias.We evaluated pretreatment ctDNA levels in 267 patients with DLBCL treated across multiple centers in Europe and the United States using Cancer Personalized Profiling by Deep Sequencing. Pretreatment ctDNA levels were correlated with DTI, total metabolic tumor volumes (TMTVs), the International Prognostic Index (IPI), and outcome.Short DTI was associated with advanced-stage disease (P < .001) and higher IPI (P < .001). We also found an inverse correlation between DTI and TMTV (RS= -0.37; P < .001). Similarly, pretreatment ctDNA levels were significantly associated with stage, IPI, and TMTV (all P < .001), demonstrating that both DTI and ctDNA reflect disease burden. Notably, patients with shorter DTI had higher pretreatment ctDNA levels (P < .001). Pretreatment ctDNA levels predicted short DTI independent of the IPI (P < .001). Although each risk factor was significantly associated with event-free survival in univariable analysis, ctDNA level was prognostic of event-free survival independent of DTI and IPI in multivariable Cox regression (ctDNA: hazard ratio, 1.5; 95% CI [1.2 to 2.0]; IPI: 1.1 [0.9 to 1.3]; -DTI: 1.1 [1.0 to 1.2]).Short DTI largely reflects baseline tumor burden, which can be objectively measured using pretreatment ctDNA levels. Pretreatment ctDNA levels therefore have utility for quantifying and guarding against selection biases in prospective DLBCL clinical trials.
Ixazomib, Daratumumab, and Low-Dose Dexamethasone in Frail Patients With Newly Diagnosed Multiple Myeloma: The Hovon 143 Study
Authors: Claudia A. M. Stege, Kazem Nasserinejad, Ellen van der Spek, Yavuz M. Bilgin, Alain Kentos, Maaike Sohne, Roel J. W. van Kampen, Inge Ludwig, Noortje Thielen, Nazik Durdu-Rayman, Nicole C. H. P. de Graauw, Niels W. C. J. van de Donk, Esther G. M. de Waal, Marie-Christiane Vekemans, Gert Jan Timmers, Marjolein van der Klift, Savita Soechit, Paul A. F. Geerts, Matthijs H. Silbermann, Margriet Oosterveld, Inger S. Nijhof, Pieter Sonneveld, Saskia K. Klein, Mark-David Levin, Sonja Zweegman
Journal: Journal of Clinical Oncology (2021)

PURPOSE Frail patients with newly diagnosed multiple myeloma have an inferior outcome, mainly because of a high discontinuation rate due to toxicity. We designed a phase II trial specifically for frail patients, evaluating the efficacy and tolerability of ixazomib-daratumumab-low-dose-dexamethasone (Ixa-Dara-dex). METHODS Sixty-five patients, who were frail according to the International Myeloma Working Group frailty index, were treated with nine induction cycles Ixa-Dara-dex followed by maintenance with Ixa-Dara for a maximum of 2 years. RESULTS The overall response rate on induction therapy was 78%. After a median follow-up of 22.9 months, median progression-free survival (PFS) was 13.8 months and 12-month overall survival (OS) was 78%. Median PFS and 12-month OS were 21.6 months and 92% in patients who were frail based on age &gt; 80 years alone, versus 13.8 months and 78%, and 10.1 months and 70% in patients who were frail based on additional frailty parameters either ≤ 80 or &gt; 80 years of age, respectively. In 51% of patients, induction therapy had to be discontinued prematurely, of which 6% because of noncompliance to study treatment, 9% because of toxicity, and 9% because of death (8% within 2 months, of which 80% because of toxicity). Quality of life improved during induction treatment, being clinically meaningful already after three induction cycles. CONCLUSION Ixa-Dara-dex lead to a high response rate and improved quality of life. However, treatment discontinuation because of toxicity and early mortality, negatively influencing PFS and OS, remains a concern in frail patients. The outcome was heterogeneous across frail subpopulations. This should be taken into account in the design and interpretation of future studies in frail patients, to pave the way for more precise treatment guidance.
Advanced Strategies of Biomimetic Tissue‐Engineered Grafts for Bone Regeneration
Authors: Chang Xie, Jinchun Ye, Renjie Liang, Xudong Yao, Xinyu Wu, Yiwen Koh, Wei Wei, Xianzhu Zhang, Hongwei Ouyang
Journal: Advanced Healthcare Materials (2021)

Abstract The failure to repair critical‐sized bone defects often leads to incomplete regeneration or fracture non‐union. Tissue‐engineered grafts have been recognized as an alternative strategy for bone regeneration due to their potential to repair defects. To design a successful tissue‐engineered graft requires the understanding of physicochemical optimization to mimic the composition and structure of native bone, as well as the biological strategies of mimicking the key biological elements during bone regeneration process. This review provides an overview of engineered graft‐based strategies focusing on physicochemical properties of materials and graft structure optimization from macroscale to nanoscale to further boost bone regeneration, and it summarizes biological strategies which mainly focus on growth factors following bone regeneration pattern and stem cell‐based strategies for more efficient repair. Finally, it discusses the current limitations of existing strategies upon bone repair and highlights a promising strategy for rapid bone regeneration.
Effectiveness of the Comirnaty (BNT162b2, BioNTech/Pfizer) vaccine in preventing SARS-CoV-2 infection among healthcare workers, Treviso province, Veneto region, Italy, 27 December 2020 to 24 March 2021
Authors: Massimo Fabiani, Mauro Ramigni, Valentina Gobbetto, Alberto Mateo-Urdiales, Patrizio Pezzotti, Cinzia Piovesan
Journal: Eurosurveillance (2021)

Data on effectiveness of the BioNTech­/Pfizer COVID-19 vaccine in real-world settings are limited. In a study of 6,423 healthcare workers in Treviso Province, Italy, we estimated that, within the time intervals of 14–21 days from the first and at least 7 days from the second dose, vaccine effectiveness in preventing SARS-CoV-2 infection was 84% (95% confidence interval (CI): 40–96) and 95% (95% CI: 62–99), respectively. These results could support the ongoing vaccination campaigns by providing evidence for targeted communication.
SPLUNC1: a novel marker of cystic fibrosis exacerbations
Authors: Sara Khanal, Megan Webster, Naiqian Niu, Jana Zielonka, Myra Nunez, Geoffrey Chupp, Martin D. Slade, Lauren Cohn, Maor Sauler, Jose L. Gomez, Robert Tarran, Lokesh Sharma, Charles S. Dela Cruz, Marie Egan, Theresa Laguna, Clemente J. Britto
Journal: European Respiratory Journal (2021)

Acute pulmonary exacerbations (AE) are episodes of clinical worsening in cystic fibrosis (CF), often precipitated by infection. Timely detection is critical to minimise morbidity and lung function declines associated with acute inflammation during AE. Based on our previous observations that airway protein short palate lung nasal epithelium clone 1 (SPLUNC1) is regulated by inflammatory signals, we investigated the use of SPLUNC1 fluctuations to diagnose and predict AE in CF.We enrolled CF participants from two independent cohorts to measure AE markers of inflammation in sputum and recorded clinical outcomes for a 1-year follow-up period.SPLUNC1 levels were high in healthy controls (n=9, 10.7 μg·mL-1), and significantly decreased in CF participants without AE (n=30, 5.7 μg·mL-1; p=0.016). SPLUNC1 levels were 71.9% lower during AE (n=14, 1.6 μg·mL-1; p=0.0034) regardless of age, sex, CF-causing mutation or microbiology findings. Cytokines interleukin-1β and tumour necrosis factor-α were also increased in AE, whereas lung function did not decrease consistently. Stable CF participants with lower SPLUNC1 levels were much more likely to have an AE at 60 days (hazard ratio (HR)±se 11.49±0.83; p=0.0033). Low-SPLUNC1 stable participants remained at higher AE risk even 1 year after sputum collection (HR±se 3.21±0.47; p=0.0125). SPLUNC1 was downregulated by inflammatory cytokines and proteases increased in sputum during AE.In acute CF care, low SPLUNC1 levels could support a decision to increase airway clearance or to initiate pharmacological interventions. In asymptomatic, stable patients, low SPLUNC1 levels could inform changes in clinical management to improve long-term disease control and clinical outcomes in CF.
LIFE IS A RODEO - STROKE AFTER MECHANICAL BULL RIDING
Authors: Brian Henstenburg, Zeel Patel, Desire Guthier, Akhil Kher, Lekha Racharla, Rahul Gupta, Paul Secheresiu, Tarick Sheikh, Bilal Saqi, Umair Tariq, Sagar Vadhar, Benjamin Sanchez, Amy Ahnert
Journal: Journal of the American College of Cardiology (2021)
AN EXTERNALLY VALIDATED MODEL TO PREDICT MORTALITY AMONG PATIENTS TREATED BY THE PULMONARY EMBOLISM RESPONSE TEAM (PERT)
Authors: Jean-Pierre Iskandar, Essa Hariri, Nicholas Kassis, Christopher Kanaan, Hayaan Kamran, Aditya Sahai, Joseph Campbell, Ihab Haddadin, Gustavo Heresi, Marcelo Gomes, Colin Wright, John Bartholomew, Scott Cameron
Journal: Journal of the American College of Cardiology (2021)
COVID-19 and the “Lost Year” for Smokers Trying to Quit
Authors: Mary Chris Jaklevic
Journal: JAMA (2021)

Carrie D. Patnode, PhD, MPH; Jillian T. Henderson, PhD, MPH; Erin L. Coppola, MPH; Joy Melnikow, MD, MPH; Shauna Durbin, MPH; Rachel G. Thomas, MPH
IMMEDIATE IMPROVEMENT IN SYSTOLIC FUNCTION FOLLOWING SONOTHROMBOLYSIS APPLIED AFTER EMERGENT PERCUTANEOUS INTERVENTION IN ANTERIOR ST SEGMENT ELEVATION MYOCARDIAL INFARCTION
Authors: Thomas Richard Porter, Ping Zeng, Feng Xie, Joan Olson, Karla Costello, Yiannis Chatzizisis, Andrew Goldsweig, David Barton, Poonam Velagapudi, Arif Albulushi, John Higgins, Edward O’Leary
Journal: Journal of the American College of Cardiology (2021)
INDIVIDUALIZING DURATION OF DUAL ANTIPLATELET THERAPY BASED ON BLEEDING RISK, ISCHEMIC RISK, OR BOTH: AN ANALYSIS FROM THE DUAL ANTIPLATELET THERAPY (DAPT) STUDY
Authors: Nino Mihatov, Eric Secemsky, Dean Kereiakes, Philippe Gabriel Steg, Donald Cutlip, Ajay Kirtane, Roxana Mehran, Bokai Zhao, Yang Song, C. Michael Gibson, Robert Yeh
Journal: Journal of the American College of Cardiology (2021)
What can lifespan variation reveal that life expectancy hides? Comparison of five high-income countries
Authors: Lucinda Hiam, Jon Minton, Martin McKee
Journal: Journal of the Royal Society of Medicine (2021)

In most countries, life expectancy at birth (e0) has improved for many decades. Recently, however, progress has stalled in the UK and Canada, and reversed in the USA. Lifespan variation, a complementary measure of mortality, increased a few years before the reversal in the USA. To assess whether this measure offers additional meaningful insights, we examine what happened in four other high-income countries with differing life expectancy trends.We calculated life disparity (a specific measure of lifespan variation) in five countries -- USA, UK, France, Japan and Canada -- using sex- and age specific mortality rates from the Human Mortality Database from 1975 to 2017 for ages 0--100 years. We then examined trends in age-specific mortality to identify the age groups contributing to these changes.USA, UK, France, Japan and Canada.aggregate population data of the above nations.Life expectancy at birth, life disparity and age-specific mortality.The stalls and falls in life expectancy, for both males and females, seen in the UK, USA and Canada coincided with rising life disparity. These changes may be driven by worsening mortality in middle-age (such as at age 40). France and Japan, in contrast, continue on previous trajectories.Life disparity is an additional summary measure of population health providing information beyond that signalled by life expectancy at birth alone.
Diagnostic accuracy of loop-mediated isothermal amplification coupled to nanopore sequencing (LamPORE) for the detection of SARS-CoV-2 infection at scale in symptomatic and asymptomatic populations
Authors: Anetta Ptasinska, Celina Whalley, Andrew Bosworth, Charlotte Poxon, Claire Bryer, Nicholas Machin, Seden Grippon, Emma L. Wise, Bryony Armson, Emma L.A. Howson, Alice Goring, Gemma Snell, Jade Forster, Chris Mattocks, Sarah Frampton, Rebecca Anderson, David Cleary, Joe Parker, Konstantinos Boukas, Nichola Graham, Doriana Cellura, Emma Garratt, Rachel Skilton, Hana Sheldon, Alla Collins, Nusreen Ahmad, Simon Friar, Daniel Burns, Tim Williams, Keith M. Godfrey, Zandra Deans, Angela Douglas, Sue Hill, Michael Kidd, Deborah Porter, Stephen P. Kidd, Nicholas J. Cortes, Veronica Fowler, Tony Williams, Alex Richter, Andrew D. Beggs
Journal: Clinical Microbiology and Infection (2021)

Rapid, high throughput diagnostics are a valuable tool, allowing the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in populations so as to identify and isolate people with asymptomatic and symptomatic infections. Reagent shortages and restricted access to high throughput testing solutions have limited the effectiveness of conventional assays such as quantitative RT-PCR (RT-qPCR), particularly throughout the first months of the coronavirus disease 2019 pandemic. We investigated the use of LamPORE, where loop-mediated isothermal amplification (LAMP) is coupled to nanopore sequencing technology, for the detection of SARS-CoV-2 in symptomatic and asymptomatic populations.In an asymptomatic prospective cohort, for 3 weeks in September 2020, health-care workers across four sites (Birmingham, Southampton, Basingstoke and Manchester) self-swabbed with nasopharyngeal swabs weekly and supplied a saliva specimen daily. These samples were tested for SARS-CoV-2 RNA using the Oxford Nanopore LamPORE system and a reference RT-qPCR assay on extracted sample RNA. A second retrospective cohort of 848 patients with influenza-like illness from March 2020 to June 2020 were similarly tested from nasopharyngeal swabs.In the asymptomatic cohort a total of 1200 participants supplied 23 427 samples (3966 swab, 19 461 saliva) over a 3-week period. The incidence of SARS-CoV-2 detection using LamPORE was 0.95%. Diagnostic sensitivity and specificity of LamPORE was >99.5% (decreasing to approximately 98% when clustered estimation was used) in both swab and saliva asymptomatic samples when compared with the reference RT-qPCR test. In the retrospective symptomatic cohort, the incidence was 13.4% and the sensitivity and specificity were 100%.LamPORE is a highly accurate methodology for the detection of SARS-CoV-2 in both symptomatic and asymptomatic population settings and can be used as an alternative to RT-qPCR.
Reply to Kunlin Yang, Xuesong Li, and Liqun Zhou’s Letter to the Editor re: Eduard Roussel, Giovanni Tasso, Riccardo Campi, et al. Surgical Management and Outcomes of Renal Tumors Arising from Horseshoe Kidneys: Results from an International Multicenter Collaboration. Eur Urol 2021;79:133–40
Authors: Eduard Roussel, Giovanni Tasso, Maarten Albersen
Journal: European Urology (2021)