tbuckley/cabot-search huggingface dataset:
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1962)

COMMITTEE ON MATERNAL WELFARE*Cesarean Section, Followed by Generalized Peritonitis and SepsisPelvic examination shortly before her fifteenth birthday disclosed pregnancy of three months' duration in a girl whose subsequent weight gain, blood pressure and urinalyses, checked weekly, were normal. Only external measurements were recorded, and these were called "adequate." Twenty-four hours after admission at term for spontaneous rupture of the membranes, cephalopelvic disproportion was suspected because of an unengaged presenting part, with contractions that remained irregular. X-ray study now revealed advanced hydrocephaly.About thirty-six hours after rupture of the membranes, contractions were recurring with poor quality at fifteen-minute intervals, . . .
FRIDAY 26TH MARCH
Authors: C Mg, Ma Newland, Ramp Gi, A Smith, Rph Logan, Gordon-Smith Jj, Owen Cave, Cata Sm, Hinds Cj, Hussaini Stone, Pereira Sh, Kennedy Sp, G Murphy, Dowling Gastro, R Patankar, I Bailey, A Sanderson, Ha Ml, Petrmnl Gl, Lauffer Rp, Jazrawi Ma, Lauri Horton, Non-Steroidal Js
Journal: Gut (1993)

Activated platelet play a role in the vascular damage associated with ischaemic heart disease and diabetes.Systemic thrnboses nay complicate active IBD and recent evidence suggests thae is sificant intestinal vascularendothelial injury in Crohn's disease.W tested the hypothesis that platelet activation contributes to the pathoguesis of IBD.METHODS: We used i) flow cytometry to quantfy the platlet surface antigens P-selectin (a specific adhesion receptor for neutrophils released from alpha-granules) and GP53 (a lysosome-derived protein), both of which are expressed on activation, and ii) ELISA to mnsure beta-thmboglobulin (B1G), a platelet-specific protein dischagd from alpha-granules on activation.Diseas activity was deined according to the modified Harvey-Bradshaw index.RESULTS: There was increased expression of surface markers in all IBD groups, and of BTG in active CD and inactive UC. % cells positive for specific fluorescent antibody marker, and serum ST in IUKml, are shown as medians nmtequardle range): n P-selectin GP53 n sTG controls 32 1.8 (1.1-3.3) 1.5 (1.0-2.6) 18 17(14-28) active CD 19 4.2 (2.0-13.8)t 2.6 (1.8-3.3)* 15 26 (19-64)* inadve CD 11 4.0 (1.6-10.7) 4.8 (1.9-5.2)* 8 15 (15-25) active UC 13 7.1 (4.1-13.6)t 4.0 (3.5-7.7)t 10 35(15-55) inactive UC 9 3.5 (2.3-5.5)* 4.5 (1.5-10.4)* 8 47 (17-282)* *p<0.05,tp<0.01 vs healthy controls using Mann-Whitney U. CONCLUSION: Platelets cirulate in an activated state in 3BD.This abnormality could contribute to the pathogenesis of BD by pming neutrophil adhesion, and by predisposing to tirombosis and infartion m the vasculatre of the bowel wall and elsewhere.
Error in the Biomarker Subsection
Authors: Gretchen Bandoli, Rebecca Baer, Dawn Gano, Laura Pawlowski, Christina Chambers, Gano Baer
Journal: JAMA Neurology (2020)

Alette M. Wessels, PhD; Pierre N. Tariot, MD; Jennifer A. Zimmer, MD; Katherine J. Selzler, PhD; Sonja M. Bragg, MPH; Scott W. Andersen, MS; John Landry, MMath; James H. Krull, PharmD; AnnCatherine M. Downing, PharmD; Brian A. Willis, PhD; Sergey Shcherbinin, PhD; Jamie Mullen, MD; Peter Barker, PhD; Jennifer Schumi, PhD; Craig Shering, DPhil; Brandy R. Matthews, MD; Robert A. Stern, PhD; Bruno Vellas, MD; Sharon Cohen, MD; Emer MacSweeney, FRCR; Mercè Boada, MD; John R. Sims, MD
Government’s plan for “living with covid-19” neglects the most vulnerable
Authors: Chaand Nagpaul
Journal: BMJ (2022)

Government's plan for "living with covid-19" neglects the most vulnerable Chaand Nagpaul BMA council chairTo doctors and much of the public, who have spent the last two years doing the right thing to protect one another, last week's "Living with covid-19" strategy appeared less about living with the virus, and more about ignoring its continued impact on people, society, and the health service.
Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma
Authors: Karla A. Lee, Andrew Maltez Thomas, Laura A. Bolte, Johannes R. Björk, Laura Kist de Ruijter, Federica Armanini, Francesco Asnicar, Aitor Blanco-Miguez, Ruth Board, Neus Calbet-Llopart, Lisa Derosa, Nathalie Dhomen, Kelly Brooks, Mark Harland, Mark Harries, Emily R. Leeming, Paul Lorigan, Paolo Manghi, Richard Marais, Julia Newton-Bishop, Luigi Nezi, Federica Pinto, Miriam Potrony, Susana Puig, Patricio Serra-Bellver, Heather M. Shaw, Sabrina Tamburini, Sara Valpione, Amrita Vijay, Levi Waldron, Laurence Zitvogel, Moreno Zolfo, Elisabeth G. E. de Vries, Paul Nathan, Rudolf S. N. Fehrmann, Véronique Bataille, Geke A. P. Hospers, Tim D. Spector, Rinse K. Weersma, Nicola Segata
Journal: Nature Medicine (2022)

Abstract The composition of the gut microbiome has been associated with clinical responses to immune checkpoint inhibitor (ICI) treatment, but there is limited consensus on the specific microbiome characteristics linked to the clinical benefits of ICIs. We performed shotgun metagenomic sequencing of stool samples collected before ICI initiation from five observational cohorts recruiting ICI-naive patients with advanced cutaneous melanoma ( n = 165). Integrating the dataset with 147 metagenomic samples from previously published studies, we found that the gut microbiome has a relevant, but cohort-dependent, association with the response to ICIs. A machine learning analysis confirmed the link between the microbiome and overall response rates (ORRs) and progression-free survival (PFS) with ICIs but also revealed limited reproducibility of microbiome-based signatures across cohorts. Accordingly, a panel of species, including Bifidobacterium pseudocatenulatum , Roseburia spp. and Akkermansia muciniphila , associated with responders was identified, but no single species could be regarded as a fully consistent biomarker across studies. Overall, the role of the human gut microbiome in ICI response appears more complex than previously thought, extending beyond differing microbial species simply present or absent in responders and nonresponders. Future studies should adopt larger sample sizes and take into account the complex interplay of clinical factors with the gut microbiome over the treatment course.
Enhanced photodynamic therapy/photothermo therapy for nasopharyngeal carcinoma via a tumour microenvironment-responsive self-oxygenated drug delivery system
Authors: Nan Wu, Yaqin Tu, Guorun Fan, Jiahui Ding, Jun Luo, Wei Wang, Chong Zhang, Caiyan Yuan, Handan Zhang, Pei Chen, Songwei Tan, Hongjun Xiao
Journal: Asian Journal of Pharmaceutical Sciences (2022)

The hypoxic nature of tumours limits the efficiency of oxygen-dependent photodynamic therapy (PDT). Hence, in this study, indocyanine green (ICG)-loaded lipid-coated zinc peroxide (ZnO2) nanoparticles (ZnO2@Lip-ICG) was constructed to realize tumour microenvironment (TME)-responsive self-oxygen supply. Near infrared light irradiation (808 nm), the lipid outer layer of ICG acquires sufficient energy to produce heat, thereby elevating the localised temperature, which results in accelerated ZnO2 release and apoptosis of tumour cells. The ZnO2 rapidly generates O2 in the TME (pH 6.5), which alleviates tumour hypoxia and then enhances the PDT effect of ICG. These results demonstrate that ZnO2@Lip-ICG NPs display good oxygen self-supported properties and outstanding PDT/PTT characteristics, and thus, achieve good tumour proliferation suppression.
OCCASIONAL DIAGNOSTIC DIFFICULTIES IN SURGERY.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Orthopaedics
Authors: Reginald R. Cooper
Journal: JAMA (1980)

These two large volumes arranged by consulting editor George Bentley encompass far more than mere operative technique. Almost every section contains a concise introductory paragraph or two, setting the given operation in its historical perspective and delineating operative indications. The author describes operative technique in a step-by-step fashion, from positioning the patient to wound closure and postoperative care. The volumes contain literally hundreds of line drawings and illustrations that undoubtedly add to the cost but represent a necessity when clarity of technique is the goal. Most illustrations convey their message well; however, several exhibit lack of contrast and a sparsity in shades of gray, which renders their quality less than superb. Color would be desirable in certain critical diagrams, but then cost would be prohibitive. The list of contributors could represent a<i>Who's Who</i>of British Orthopaedics, with the distinct advantage of having an expert to describe each procedure. Conversely,
Forthcoming Meetings
Journal: Neuro-Oncology (2021)

Additional criteria apply.Please refer to protocol 14379-201 for full inclusion and exclusion criteria.† Patients can participate if they had some skin cancers, superficial bladder cancer (cancer that was only on the surface of the lining of the bladder), or carcinoma in situ (cancer that had not spread) of the cervix or breast that had been cured.HIV, human immunodeficiency virus; HBV, hepatitis B virus; HCV, hepatitis C virus; IGF-1R, insulin-like growth factor 1 receptor; KPS, Karnofsky Performance Scale; RT, radiotherapy; SOC, standard of care; TMZ, temozolomide.
Ephrin-A3/EphA2 axis regulates cellular metabolic plasticity to enhance cancer stemness in hypoxic hepatocellular carcinoma
Authors: Abdullah Husain, Yung-Tuen Chiu, Karen Man-Fong Sze, Daniel Wai-Hung Ho, Yu-Man Tsui, Eliana Mary Senires Suarez, Vanilla Xin Zhang, Lo-Kong Chan, Eva Lee, Joyce Man-Fong Lee, Tan-To Cheung, Carmen Chak-Lui Wong, Clive Yik-Sham Chung, Irene Oi-Lin Ng
Journal: Journal of Hepatology (2022)
Hyperthermia based individual in situ recombinant vaccine enhances lymph nodes drainage for de novo antitumor immunity
Authors: Cuixia Zheng, Xinxin Liu, Yueyue Kong, Lei Zhang, Qingling Song, Hongjuan Zhao, Lu Han, Jiannan Jiao, Qianhua Feng, Lei Wang
Journal: Acta Pharmaceutica Sinica B (2022)

The continuing challenges that limit effectiveness of tumor therapeutic vaccines were high heterogeneity of tumor immunogenicity, low bioactivity of antigens, as well as insufficient lymph nodes (LNs) drainage of antigens and adjuvants. Transportation of in situ neoantigens and adjuvants to LNs may be an effective approach to solve the abovementioned problems. Therefore, an FA-TSL/AuNCs/SV nanoplatform was constructed by integrating simvastatin (SV) adjuvant loaded Au nanocages (AuNCs) as cores (AuNCs/SV) and folic acid modified thermal-sensitive liposomes (FA-TSL) as shells to enhance de novo antitumor immunity. After accumulation in tumor guided by FA, AuNCs mediated photothermal therapy (PTT) induced the release of tumor-derived protein antigens (TDPAs) and the shedding of FA-TSL. Exposed AuNCs/SV soon captured TDPAs to form in situ recombinant vaccine (AuNCs/SV/TDPAs). Subsequently, AuNCs/SV/TDPAs could efficiently transport to draining LNs owing to the hyperthermia induced vasodilation effect and small particle size, achieving co-delivery of antigens and adjuvant for initiation of specific T cell response. In melanoma bearing mice, FA-TSL/AuNCs/SV and laser irradiation effectively ablated primary tumor, against metastatic tumors and induced immunological memory. This approach served a hyperthermia enhanced platform drainage to enable robust personalized cancer vaccination.
Primary Carcinoma of the Duodenum
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evidence on acupuncture therapies is underused in clinical practice and health policy
Authors: Liming Lu, Yuqing Zhang, Xiaorong Tang, Shuqi Ge, Hao Wen, Jingchun Zeng, Lai Wang, Zhao Zeng, Gabriel Rada, Camila Ávila, Camilo Vergara, Yuyuan Tang, Peiming Zhang, Rouhao Chen, Yu Dong, Xiaojing Wei, Wen Luo, Lin Wang, Gordon Guyatt, Chunzhi Tang, Nenggui Xu
Journal: BMJ (2022)
A Treatise on the Diseases of Infancy and Childhood.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Current Comment
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Author Correction: Reply to: Postbiotics — when simplification fails to clarify
Authors: Seppo Salminen, Maria Carmen Collado, Akihito Endo, Colin Hill, Sarah Lebeer, Eamonn M. M. Quigley, Mary Ellen Sanders, Raanan Shamir, Jonathan R. Swann, Hania Szajewska, Gabriel Vinderola
Journal: Nature Reviews Gastroenterology & Hepatology (2022)
Differences/Disorders of Sex Development: Medical Conditions at the Intersection of Sex and Gender
Authors: David E. Sandberg, Melissa Gardner
Journal: Annual Review of Clinical Psychology (2022)

Defined as congenital conditions in which development of chromosomal, gonadal, or anatomic sex is atypical, differences or disorders of sex development (DSDs) comprise many discrete diagnoses ranging from those associated with few phenotypic differences between affected and unaffected individuals to those where questions arise regarding gender of rearing, gonadal tumor risk, genital surgery, and fertility. Controversies exist in numerous areas including how DSDs are conceptualized, how to refer to the set of conditions and those affected by them, and aspects of clinical management that extend from social media to legislative bodies, courts of law, medicine, clinical practice, and scholarly research in psychology and sociology. In addition to these aspects, this review covers biological and social influences on psychosocial development and adjustment, the psychosocial and psychosexual adaptation of people born with DSDs, and roles for clinical psychologists in the clinical management of DSDs.
Disseminated Cryptococcosis
Authors: Lisa Akintilo, Alisa Femia
Journal: New England Journal of Medicine (2021)

A 49-year-old woman with a history of kidney transplantation presented with headache and umbilicated skin papules. Levels of cryptococcal antigen in the serum and cerebrospinal fluid were high. A skin biopsy was performed, and a diagnosis of disseminated cryptococcosis was confirmed.
The Runaway Evolution of SARS-CoV-2 Leading to the Highly Evolved Delta Strain
Authors: Yongsen Ruan, Mei Hou, Xiaolu Tang, Xionglei He, Xuemei Lu, Jian Lu, Chung-I Wu, Haijun Wen
Journal: Molecular Biology and Evolution (2022)

In new epidemics after the host shift, the pathogens may experience accelerated evolution driven by novel selective pressures. When the accelerated evolution enters a positive feedback loop with the expanding epidemics, the pathogen's runaway evolution may be triggered. To test this possibility in coronavirus disease 2019 (COVID-19), we analyze the extensive databases and identify five major waves of strains, one replacing the previous one in 2020-2021. The mutations differ entirely between waves and the number of mutations continues to increase, from 3-4 to 21-31. The latest wave in the fall of 2021 is the Delta strain which accrues 31 new mutations to become highly prevalent. Interestingly, these new mutations in Delta strain emerge in multiple stages with each stage driven by 6-12 coding mutations that form a fitness group. In short, the evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from the oldest to the youngest wave, and from the earlier to the later stages of the Delta wave, is a process of acceleration with more and more mutations. The global increase in the viral population size (M(t), at time t) and the mutation accumulation (R(t)) may have indeed triggered the runaway evolution in late 2020, leading to the highly evolved Alpha and then Delta strain. To suppress the pandemic, it is crucial to break the positive feedback loop between M(t) and R(t), neither of which has yet to be effectively dampened by late 2021. New waves after Delta, hence, should not be surprising.
Dual Checkpoint Blockade Takes Aim at Relapsed Mesothelioma
Journal: Cancer Discovery (2017)

In the largest clinical trial to date of immune checkpoint inhibitors for mesothelioma, patients treated with nivolumab-either alone or in combination with ipilimumab-posted impressive response rates and survival outcomes, according to data presented at the 2017 American Society of Clinical Oncology Annual Meeting. However, the combination, although more effective, was also more toxic.
The relationship between congenital heart disease and cancer in Swedish children: A population-based cohort study
Authors: Christina-Evmorfia Kampitsi, Hanna Mogensen, Maria Feychting, Giorgio Tettamanti
Journal: PLoS Medicine (2022)

Background Birth defects have been consistently associated with elevated childhood cancer risks; however, the relationship between congenital heart disease (CHD) and childhood cancer remains conflicting. Considering the increasing patient population with CHD after improvements in their life expectancies, insights into this relationship are particularly compelling. Thus, we aimed to determine the relationship between CHD and cancer in Swedish children. Methods and findings All individuals registered in the Swedish Medical Birth Register (MBR) between 1973 and 2014 were included in this population–based cohort study ( n = 4,178,722). Individuals with CHD ( n = 66,892) were identified from the MBR and National Patient Register, whereas cancer diagnoses were retrieved from the Swedish Cancer Register. The relationship between CHD and childhood cancer (&lt;20 years at diagnosis) was evaluated using Cox proportional hazards regression models. We observed increased risks of cancer overall, leukemia, lymphoma, and hepatoblastoma in children with CHD, but after adjustment for Down syndrome, only the increased lymphoma (hazard ratio (HR) = 1.64, 95% confidence interval (CI) 1.11 to 2.44) and hepatoblastoma (HR = 3.94, 95% CI 1.83 to 8.47) risk remained. However, when restricting to CHD diagnoses from the MBR only, i.e., those diagnosed around birth, the risk for childhood cancer overall (HR = 1.45, 95% CI 1.23 to 1.71) and leukemia (HR = 1.41, 95% CI 1.08 to 1.84) was more pronounced, even after controlling for Down syndrome. Finally, a substantially elevated lymphoma risk (HR = 8.13, 95% CI 4.06 to 16.30) was observed in children with complex CHD. Limitations of the study include the National Patient Register not being nationwide until 1987, in addition to the rareness of the conditions under study providing limited power for analyses on the rarer cancer subtypes. Conclusions We found associations between CHD and childhood lymphomas and hepatoblastomas not explained by a diagnosis of Down syndrome. Stronger associations were observed in complex CHD.