tbuckley/cabot-search huggingface dataset:
Hematology
Authors: T. H. Spaet
Journal: JAMA (1979)

<b>I was fortunate, indeed, to persuade Theodore Spaet, MD, to prepare the hematologic article for</b>CONTEMPO<b>'79. In his opening paragraphs he describes the reasons why Old Guard hematologists can no longer be all things to all people. For specialized considerations we must, from time to time, call on uninhibitedly energetic skilled men like Spaet</b>. Time was when the borders of hematology were well defined, and its citizens could cover its area reasonably well. Barely 25 years ago, a competent hematologist could give the complete course to medical students singlehandedly. Today this unity has become a group of separate territories inhabited by "clotters," blood bankers, leukemologists, hemoglobinologists, and immunologists (to mention only a few separatists). They have their own exclusive conventions at different times and in different locations; they even have their own journals and subspecialty boards as well. Much as the Old Guard may protest, however, a wondrous thing appears to be happening. As fragmentation within proceeds, there is a simultaneous weakening of the previously well-defined borders of hematology. Each subspecialty reaches out to the resources of others and to more distant, once forgotten neighbors. As a result the gap between theoretical knowledge and direct patient benefit is narrowing. Some examples of this appear to have farreaching consequences.—W.R.C.
Reducing Health Disparities Through Achieving Pharmacoequity—Reply
Authors: Utibe R. Essien, Stacie B. Dusetzina, Walid F. Gellad
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Self-assembly of nanomicelles with rationally designed multifunctional building blocks for synergistic chemo-photodynamic therapy
Authors: Guidong Gong, Jiezhou Pan, Yunxiang He, Jiaojiao Shang, Xiaoling Wang, Yaoyao Zhang, Guolin Zhang, Fei Wang, Gang Zhao, Junling Guo
Journal: Theranostics (2022)

Rationale:The combination of photosensitizers, oxygen supply agents, and adjuvant therapy drugs in a single nano-drug delivery system for photodynamic therapy (PDT) has been showing great promises to overcome the inherent challenges of PDT for tumor treatment.However, the complicated preparation of integrating multiple components hampers their further developments.Here, we describe a self-assembly nanomicelle with rationally designed building blocks, which shows a high efficiency of synergistic chemo-photodynamic therapy in the animal modal.Methods: The nanomicelle was prepared by a coordination-driven self-assembly based on a rationally designed ferrocene cyclopalladated compound coupled with photosensitizers and hyaluronic acid (referred to as FCP-Tph/HA).The morphology, targeting drug delivery, pharmacokinetics, hemolysis, and multimodal synergistic therapy of FCP-Tph/HA were investigated.Results: The formation of nanomicelles presents a low hemolysis rate and a prolonged blood circulation time.FCP-Tph/HA possesses an enhanced antitumor effect in vitro through the specific binding of HA to CD44 and combining chemotherapy with oxygen self-supplying PDT.Simultaneously, the nanomicelle facilitates a significantly improved antitumor efficacy (>90% tumor regression) on a breast cancer model in vivo.Conclusion: Our results present a modular self-assembled nanomicellar platform with synergistic chemo-photodynamic therapy for challenging PDT-based tumor treatment.
AIDS commission experiences more changes
Authors: C. Marwick
Journal: JAMA (1987)

THE PRESIDENTIAL Commission on the Human Immunodeficiency Virus (HIV) Epidemic keeps running into trouble. On the heels of the forced resignation of its executive director, Linda Sheaffer (<i>JAMA</i>1987;258:2023-2024), two leading members—W. Eugene Mayberry, MD, chair, and Woodrow A. Myers, MD, co-chair—now also have resigned. Taking over as chair is ADM (Ret) James D. Watkins, a former chief of US Naval Operations. Shortly after his appointment, Watkins announced that Polly L. Gault, former staff director of the Senate Subcommittee on Education, Arts, and the Humanities, would become the commission's executive director. Gault, he said, "has a background in education and health, is thoroughly familiar with the legislative process, and has proven managerial talent—precisely the person needed at this critical juncture." Watkins said he would have additional staff appointments to announce in the near future. Also, he said, the White House has informed him that two new commission members soon will
Awards, Appointments, Announcements
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Awards, Appointments, Announcements Get access JNCI: Journal of the National Cancer Institute, Volume 84, Issue 22, 18 November 1992, Pages 1696–1698, https://doi.org/10.1093/jnci/84.22.1696-a Published: 18 November 1992
FORGOTTEN CALORIES
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Long COVID symptoms in SARS-CoV-2-positive adolescents and matched controls (LongCOVIDKidsDK): a national, cross-sectional study
Authors: Selina Kikkenborg Berg, Susanne Dam Nielsen, Ulrikka Nygaard, Henning Bundgaard, Pernille Palm, Camilla Rotvig, Anne Vinggaard Christensen
Journal: The Lancet Child & Adolescent Health (2022)
LOW RATES FOR THE PORTLAND SESSION.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Blood Ethanol
Authors: Keith B. Hammond
Journal: JAMA (1973)

A young woman with an unusually high blood ethanol level (780 mg/100 ml) was admitted to the emergency room at the University of Colorado Medical Center following an automobile accident. This case is presented because of the exceptional degree of central nervous system tolerance exhibited by the patient and because her ethanol elimination rate appeared to follow first-order kinetics instead of the zero-order kinetics usually seen in the metabolism of ethanol in normal individuals.
When and How Would You Screen This Patient for Cervical Cancer?
Authors: Eileen E. Reynolds, Amy Weinstein, Huma Farid, Howard Libman
Journal: Annals of Internal Medicine (2022)

Successful screening programs based on cervical cytology have dramatically reduced the incidence of cervical cancer in the United States. Human papillomavirus immunization is poised to reduce it further as an increasing percentage of vaccinated women reach adulthood. A recent guideline from the American Cancer Society advises that cervical cancer screening begin at age 25 and that high-risk human papillomavirus testing is the preferred screening test. The U.S. Preventive Services Task Force recommends screening begin at age 21 and that cytology remain incorporated into screening. Here, 2 experts debate how to apply these guidelines to Ms. L, a 22-year-old woman who has never undergone cervical cancer screening.
Queries and Minor Notes
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Practical Treatise on the Function and Diseases of the Unimpregnated Womb
Journal: BMJ (1840)

Chlorosis, amenorrhcea, vicarious menstruation, dysmenorrlhac menorrhagia, leucorrboha, and the disorders at- tending the decline of menstruation.We cannot, on the present occasion, lay before our readers an analysis of any of the chapters in which these sul)jects are successively examined; butwre undertake to do so in a future number, and in the mean time content ourselves with certifying, in general terms, to the practical excellency of Dr. Aslhwell's treatise.
Landmark article Dec 23, 1922. Medicolegal application of human blood grouping. Third communication. By R. Ottenberg
Authors: R. Ottenberg
Journal: JAMA (1983)

Since 1907, when I did the first transfusion recorded in which tests for blood compatibility were made,<sup>1</sup>I have performed many thousand blood group tests. Occasionally I have had to correct my own errors as well as those of others. Experience with successive generations of hospital interns has taught me that, in spite of the simplicity of the test, most beginners will make mistakes in grouping unless specifically taught about certain sources of error. The subject is particularly important at present because: (1) Blood transfusion is being increasingly used; (2) the group test will probably be employed in the near future in medicolegal work, and (3) Buchanan's recent articles<sup>2</sup>denying the correctness of all the preceding work on the heredity of the blood groups make it necessary for some other person to do an extensive piece of investigation. <h3>WHAT IS THE BEST TECHNIC?</h3> A number of different methods
A national vaccination service for the NHS in England: a proposal to be considered with caution
Authors: Simon Hodes, Sian Stanley, Azeem Majeed
Journal: BMJ (2022)

The health secretary, Sajid Javid, announced on 26 January that a "national vaccination service" is required to provide mass covid-19 vaccination to the population of England. 1 Speaking at a House of Commons Health and Social Care Committee meeting, Javid suggested the proposed service could cover other vaccines as well as vaccines for covid-19.The rationale is that NHS general practice is under great strain, and by removing some services that can be provided elsewhere, it will free up time for primary care teams to concentrate on their core work.
The Nature and Treatment of Amentia: Psychoanalysis and Mental Arrest in Relation to the Science of Intelligence
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immunological Memory
Authors: David Gray
Journal: Annual Review of Immunology (1993)

The past five or six years has seen a resurgence of interest in immunological memory. Areas in which important advances have been made of late or in which problems in understanding persist are covered here: (i) Selection of virgin B cells for entry into the peripheral pool. (ii) Expression of immunoglobulin isotypes and other markers on memory B cells. (iii) Development of memory B cells as a separate lineage from primary response B cells. (iv) Sites of production of memory B cells. (v) Signals that rescue mutating B cells in germinal centers, forming the basis of affinity selection, and programming further differentiation. (vi) The myriad markers of memory T cells, in particular CD45R isoforms. (vii) Selective migration pathways of memory T cells and its possible molecular basis. (viii) The lifespan of memory cells and factors that influence their long-term survival. The data accumulated during this period which have vastly increased our understanding of memory have at the same time highlighted unresolved problems that could block further progress in the field. The thorny question that we cannot at present answer is: How does a memory cell differ from an activated cell and, in the case of T cells, from an effector cell? The problem bears on the interpretation of any study that sets out to correlate memory phenotype with memory function. Immunologists may have donned an intellectual straitjacket in their search for the memory cell.
Malaria
Authors: Kristin Walter, Chandy C. John
Journal: JAMA (2022)

MalariaMalaria is a disease caused by parasites that infect human red blood cells.Malaria is typically transmitted to humans by the bite of a female Anophelesmosquito,thecarrierofPlasmodiumparasites.Ofthe5parasite species that infect humans, Plasmodium falciparum is associated with the highest death rates.
SCHENK'S THEORY OF SEX DETERMINATION.
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Criteria for the Diagnosis of Alcoholism
Journal: American Journal of Psychiatry (1972)

These criteria were compiled by a committee of medical authorities from the National Council on Alcoholism to establish guidelines for the proper diagnosis and evaluation of this disease. Criteria are weighted for diagnostic significance and assembled according to types: Physiological and Clinical (including major alcohol-associated illnesses) and Behavioral, Psychological, and Attitudinal. Because early diagnosis is helpful in treatment and recovery, manifestations are separated into their earlier and later phases. There are brief discussions of recurrent and arrested alcoholism, cross-dependence, and the types of persons at high risk of alcoholism.
Syphilis therapy regimens
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ferroptosis in cancer and cancer immunotherapy
Authors: Lei Zhao, Xiaoxue Zhou, Feng Xie, Lei Zhang, Haiyan Yan, Jun Huang, Chong Zhang, Fangfang Zhou, Jun Chen, Long Zhang
Journal: Cancer Communications (2022)

Abstract The hallmark of tumorigenesis is the successful circumvention of cell death regulation for achieving unlimited replication and immortality. Ferroptosis is a newly identified type of cell death dependent on lipid peroxidation which differs from classical programmed cell death in terms of morphology, physiology and biochemistry. The broad spectrum of injury and tumor tolerance are the main reasons for radiotherapy and chemotherapy failure. The effective rate of tumor immunotherapy as a new treatment method is less than 30%. Ferroptosis can be seen in radiotherapy, chemotherapy, and tumor immunotherapy; therefore, ferroptosis activation may be a potential strategy to overcome the drug resistance mechanism of traditional cancer treatments. In this review, the characteristics and causes of cell death by lipid peroxidation in ferroptosis are briefly described. In addition, the three metabolic regulations of ferroptosis and its crosstalk with classical signaling pathways are summarized. Collectively, these findings suggest the vital role of ferroptosis in immunotherapy based on the interaction of ferroptosis with tumor immunotherapy, chemotherapy and radiotherapy, thus, indicating the remarkable potential of ferroptosis in cancer treatment.
Neurotoxicity following CD19/CD28ζ CAR T-cells in children and young adults with B-cell malignancies
Authors: Haneen Shalabi, Staci Martin, Bonnie Yates, Pamela L Wolters, Claire Kaplan, Hannah Smith, Christopher R Sesi, Jennifer Jess, Mary Anne Toledo-Tamula, Kari Struemph, Cindy P Delbrook, Omar I Khan, Crystal L Mackall, Daniel W Lee, Nirali N Shah
Journal: Neuro-Oncology (2022)

Neurotoxicity is an established toxicity of CD19 CAR T-cell therapy; however, there is little information on neurotoxicity in children, adolescents, and young adults (CAYA) receiving CD19/CD28ζ CAR T-cells for B-cell malignancies.We analyzed neurotoxicity of CD19/CD28ζ CAR T-cells in CAYA treated on a phase I study (NCT01593696). Assessments included daily inpatient monitoring, caregiver-based neuro-symptom checklist (NSC), exploratory neurocognitive assessments, clinically-indicated imaging, CSF analysis, and systematic cytokine profiling, outcomes of which were associated with cytokine release syndrome (CRS) and treatment response postinfusion. Patients with active CNS leukemia were included.Amongst 52 patients treated, 13 patients had active CNS leukemia at infusion. Neurotoxicity was seen in 11/52 (21.2%) patients, with an incidence of 29.7% (11/37) in patients with CRS. Neurotoxicity was associated with the presence and severity of CRS. Those with neurotoxicity had higher levels of peak serum IL-6, IFNγ, and IL-15. Additionally, CNS leukemia was effectively eradicated in most patients with CRS. Pilot neurocognitive testing demonstrated stable-to-improved neurocognitive test scores in most patients, albeit limited by small patient numbers. The NSC enabled caregiver input into the patient experience.This is the first systematic analysis of neurotoxicity utilizing a CD19/CD28ζ CAR construct in CAYA, including in those with active CNS involvement. The experience demonstrates that the neurotoxicity profile was acceptable and reversible, with evidence of anti-leukemia response and CNS trafficking of CAR T-cells. Additionally, neurocognitive testing, while exploratory, provides an opportunity for future studies to employ systematic evaluations into neurotoxicity assessments and validation is needed in future studies.