tbuckley/cabot-search huggingface dataset:
Abstract 198: Multipotent Placenta-derived Cdx2 Cells Possess in vitro and in vivo Cardiomyogenic Potential
Authors: Sangeetha Vadakke Madathil, Amaresh Ranjan, Jesse Yoon, Joseph Tripodi, Koen Raedschelders, Sarah Parker, Vesna Najfeld, Jennifer Van Eyk, Hina Chaudhry
Journal: Circulation Research (2017)

Stem cell-based therapies for cardiac regeneration are of crucial importance and an ideal cell-type is yet to be established. We previously reported that fetal cells from placenta “home” to injured maternal heart and approximately 40% (40/100) of the migrating cells expressed homeodomain protein Cdx2. This interesting observation led us to hypothesize that placental Cdx2 could be a novel cell target for cardiac differentiation. To understand this phenomenon, we employed a cre-lox strategy that labeled Cdx2 cells in placenta with e-GFP and induced myocardial infarction (MI) in pregnant mice at mid-gestation. The maternal heart was analyzed 4 weeks post-MI for the presence of Cdx2-eGFP-derived cardiomyocytes. Additionally, Cdx2 cells were isolated from late-gestation placenta and assayed for cardiac differentiation in vitro followed by live cell imaging. Phenotypic and whole-cell proteomic analysis, clonal and vascular lineage differentiation and immune profiling were carried out subsequently. We observed that Cdx2 cells migrated to injured maternal hearts and differentiated into cardiomyocytes highlighting the functional significance of fetal-maternal stem cell transfer. Additionally, isolated Cdx2 cells from the late placenta differentiated into spontaneously beating cardiomyocytes and expressed structural proteins cardiac troponin T(cTnT), α-sarcomeric actinin and gap junction protein Cx43. These cells underwent clonal expansion and differentiated into endothelial and smooth muscle lineages in culture indicative of their multipotent nature. Low expression of MHC molecules and other components of the immune-response, infer that these cells possess the ability to evade host immune surveillance. Proteomic analysis demonstrated that 145 proteins were uniquely identified in the Cdx2 cells compared to embryonic stem cells. These protein networks reflected an increased activation of functions involving migration, fertility, homing, and chemotaxis. Our study is the first to demonstrate that Cdx2 may play a role in cardiac differentiation and delineate multipotent cells in placenta with an inherent “homing” ability. These findings point to a potential role for Cdx2 cells in cardiac regenerative therapies using allogeneic cells.
Nivolumab (NIVO) + 5-fluorouracil/leucovorin/oxaliplatin (mFOLFOX6)/bevacizumab (BEV) versus mFOLFOX6/BEV for first-line (1L) treatment of metastatic colorectal cancer (mCRC): Phase 2 results from CheckMate 9X8.
Authors: Heinz-Josef Lenz, Aparna Raj Parikh, David R. Spigel, Allen Lee Cohn, Takayuki Yoshino, Mark D. Kochenderfer, Elena Elez, Spencer H. Shao, Dustin A. Deming, Regan C. Holdridge, Timothy Larson, Eric Chen, Amit Mahipal, Antonio Ucar, Dana Cullen, Edwina S Baskin-Bey, Jean-Marie Ledeine, Amy Hammell, Josep Tabernero
Journal: Journal of Clinical Oncology (2022)

8 Background: Standard 1L therapies for mCRC include a fluoropyrimidine with oxaliplatin and/or irinotecan, and a biologic agent. NIVO may enhance antitumor activity in combination with 1L standard therapies within a subset of patients (pts) with mCRC. CheckMate 9X8 evaluated NIVO + mFOLFOX6/BEV vs mFOLFOX6/BEV in 1L mCRC (NCT03414983). Methods: Adults with previously untreated, unresectable, mCRC were randomized 2:1 to NIVO 240 mg + mFOLFOX6/BEV Q2W (NIVO + standard-of-care [SOC]) or mFOLFOX6/BEV Q2W (SOC). Primary endpoint was progression-free survival (PFS) assessed by blinded independent central review (BICR) per RECIST v1.1. Key secondary endpoints included objective response rate (ORR), disease control rate (DCR), time to response (TTR), duration of response (DOR), overall survival (OS), and safety. Results: 195 pts were randomized to NIVO + SOC (n = 127) or SOC (n = 68). Median (range) follow-up was 23.7 (0–33.2) months (mo; NIVO + SOC) vs 23.2 (0–32.3) mo (SOC). Median (range) duration of therapy was 9.9 (0.1–31.8+) mo (NIVO + SOC) and 7.7 (0.1–26.7+) mo (SOC). The HR (95% CI) for PFS was 0.81 (0.53–1.23; P = 0.30), which did not meet the prespecified threshold for statistical significance (median PFS, 11.9 mo in both arms; Table). PFS rates after 12 mo were higher with NIVO + SOC vs SOC (Table). ORR was 60% (NIVO + SOC) and 46% (SOC; odds ratio 1.72 [95% CI 0.96–3.10]) and median (95% CI) DOR was 12.9 (9.0–13.1) mo (NIVO + SOC) and 9.3 (7.5–11.3) mo (SOC; Table). Rates of grade 3−4 treatment-related adverse events (TRAEs) were higher with NIVO + SOC; however, no new safety signals were identified (Table). Biomarker analyses, including tumor mutational burden and baseline CD8 levels, will be presented. Conclusions: The primary endpoint of PFS was not met; however, NIVO + SOC showed higher PFS rates after 12 mo, a higher response rate, and more durable responses compared with SOC, along with acceptable safety, in 1L mCRC. Clinical trial information: NCT03414983. [Table: see text]
Military traumatic brain injury: a challenge straddling neurology and psychiatry
Authors: Ling-Zhuo Kong, Rui-Li Zhang, Shao-Hua Hu, Jian-Bo Lai
Journal: Military Medical Research (2022)

Military psychiatry, a new subcategory of psychiatry, has become an invaluable, intangible effect of the war. In this review, we begin by examining related military research, summarizing the related epidemiological data, neuropathology, and the research achievements of diagnosis and treatment technology, and discussing its comorbidity and sequelae. To date, advances in neuroimaging and molecular biology have greatly boosted the studies on military traumatic brain injury (TBI). In particular, in terms of pathophysiological mechanisms, several preclinical studies have identified abnormal protein accumulation, blood-brain barrier damage, and brain metabolism abnormalities involved in the development of TBI. As an important concept in the field of psychiatry, TBI is based on organic injury, which is largely different from many other mental disorders. Therefore, military TBI is both neuropathic and psychopathic, and is an emerging challenge at the intersection of neurology and psychiatry.
MMP3 (stromelysin-1) genetic polymorphism distribution in patients with aneurysmal coronary artery disease Nicolas Lamblin, Christophe Bauters, Nicole Helbecque, Xavier Hermant, Michel Bertrand, Philippe Amouyel. INSERM U508, LILLE, France, H�pital Cardiologique, LILLE, France
Journal: Journal of the American College of Cardiology (2001)
TCT-487 Renal Sympathetic Denervation for Resistant Hypertension in the Real World Clinical Practice: Results of the Symplicity Venezuelan Registry
Authors: Humberto S. Casal, Carlos A. Collet, Nusen Beer, Bruno Burger, Victor Bellera, Carlos Caldera, Humberto Casal Heredia, Jose Condado, Roberto C. Correa, Enrique Fermin, Carlos Galan, Mauro Herrera, Pedro Hidalgo, Carlos E. Leon, Juan Simon Muñoz, Cesar Ochoa, Aguiar Pedro, Victor Rodriguez, Jose Miguel Torres, Gabriel Varnagy, Jose Robinson Vasquez
Journal: Journal of the American College of Cardiology (2013)
Geographical miss: Impact on the restenosis rate in relation to the type of injury. Insights from the beta radiation in Europe (BRIE) study Georgios Sianos, Marco Costa, Ken Kozuma, Patrick I. Kay, Stephane G. Carlier, Marie-Angele Morel, Patrick W. Serruys. University Hospital Dijkzigt, Interventional Cardiology, Thoraxcenter, Rotterdam, The Netherlands, Cardialysis BV, Rotterdam, The Netherlands
Journal: Journal of the American College of Cardiology (2001)
ILLITERACY AND MORTALITY
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hydatidiform mole and hyperthyroidism.
Journal: BMJ (1971)

no statistically significant differences between cancer and control households in the proportion of households with these pets, the average number of pets owned during the previous 10 years, the average number of years that pets had been owned, the degree of handling of pets, or the spectrum of illnesses in pets.Less than 30%/O of the patients with cancer belonged to families that owned cats.Hanes and his colleagues refer to an unpublished case- control survey by R. Schneider in northern California.In this study the households in which cats had died from histologically confirmed cancer were compared with control households with healthy cats.Schneider found no excess of human cancer in the former.None of these findings completely exclude the possibility that isolated cases of cancer in man result from infection with oncogenic viruses transmitted from cats or other pets, but they strongly suggest that sudh transmission plays little part in the causation of human cancers in general.
William Harvey's diploma from Padua
Journal: JAMA (1966)

To all and singular who shall see, read, or hear read the present special grant of a Doctorate, Sigismund de Capilisti, of Padua, Count of the Sacred Palace of the Lateran, and of the Court of the Caesars, and of the Imperial Consistory, etc., gives salutation in Him who is the Salvation of all men. A praiseworthy custom was in vogue in old time among our ancestors, and has lasted to this day, that they who devoted themselves to the study of the various parts of divine learning, and became highly proficient therein, should be enrolled with due honour in the company of right learned men. A custom, indeed, of great sanctity, and instituted with excellent reason, for it is agreeable to law and justice that those who when proved in a fair contest are pronounced fit and worthy, should be crowned with the laurel of a Doctorate. We therefore
Surveillance and characteristics of food-borne outbreaks in the Netherlands, 2006 to 2019
Authors: Ingrid HM Friesema, Ife A Slegers-Fitz-James, Ben Wit, Eelco Franz
Journal: Eurosurveillance (2022)

BackgroundA wide variety of pathogens can cause disease in humans via consumption of contaminated food. Although food-borne outbreaks only account for a small part of the food-borne disease burden, outbreak surveillance can provide insights about the pathogens, food products implied as vehicle, points of contamination, and the settings in which transmission occurs.AimTo describe the characteristics of food-borne outbreaks registered between 2006 and 2019 in the Netherlands.MethodsAll reported outbreaks in which the first case occurred during 2006-19 were analysed. We examined the number of outbreaks, cases and setting by year, aetiology, type of evidence and food commodities.ResultsIn total, 5,657 food-borne outbreaks with 27,711 cases were identified. The contaminated food product could be confirmed in 152 outbreaks (2.7%); in 514 outbreaks (9.1%), a pathogen was detected in cases and/or environmental swabs. Norovirus caused most outbreaks (205/666) and most related cases (4,436/9,532), followed by Salmonella spp. (188 outbreaks; 3,323 cases) and Campylobacter spp. (150 outbreaks; 601 cases). Bacillus cereus was most often found in outbreaks with a confirmed food vehicle (38/152). Additionally, a connection was seen between some pathogens and food commodities. Public eating places were most often mentioned as a setting where the food implicated in the outbreak was prepared.ConclusionLong-term analysis of food-borne outbreaks confirms a persistent occurrence. Control and elimination of food-borne illness is complicated since multiple pathogens can cause illness via a vast array of food products and, in the majority of the outbreaks, the pathogen remains unknown.
Contents
Authors: Roger Steinert, Ursula Hahn, Bernhard Ko ¨lbl, Thomas Neuhann, Kaweh Schayan-Araghi, Stefanie Schmickler, Kurt Von Wolff, Josef Weindler, Thomas Will, Irmingard Neuhann, Jessica Chang, Euna Koo, Elvira Agro, Joelle Hallak, Traci Clemons, Dimitri Azar, Bonnie Henderson, Johnny Gayton, Simon Chandler, James Gow, Sharon Klier, Timothy Mcnamara, Niranjan Pehere, Sreedhar Bojja, Geeta Vemuganti, Pravin Vaddavalli, Monica Samant, Subhadra Do, Manjushree Jalali, Carol Shields, Aparna Ramasubramanian, Phoebe Mellen, Jerry Shields, Victor Hu, Helen Weiss, Patrick Massae, Paul Dceh, William Drph, David Makupa, Robin Mabey, Matthew Bailey, Anthony King, Samreen Uppal, Alan Rotchford, Arun Lakshumanan, Asiya Frcophth, Emer Abedin, Cong Ye, Elaine To, Robert Weinreb, Marco Yu, Shu Liu, Dennis Lam, Christopher Leung
Journal: Ophthalmology (2011)
Lentiviral globin gene therapy with reduced-intensity conditioning in adults with β-thalassemia: a phase 1 trial
Authors: Farid Boulad, Aurelio Maggio, Xiuyan Wang, Paolo Moi, Santina Acuto, Friederike Kogel, Chayamon Takpradit, Susan Prockop, Jorge Mansilla-Soto, Annalisa Cabriolu, Ashlesha Odak, Jinrong Qu, Keyur Thummar, Fang Du, Lingbo Shen, Simona Raso, Rita Barone, Rosario Di Maggio, Lorella Pitrolo, Antonino Giambona, Maura Mingoia, John K. Everett, Pascha Hokama, Aoife M. Roche, Vito Adrian Cantu, Hriju Adhikari, Shantan Reddy, Eric Bouhassira, Narla Mohandas, Frederic D. Bushman, Isabelle Rivière, Michel Sadelain
Journal: Nature Medicine (2022)
Prospective randomized comparison of pulsed and continuous energy delivery in catheter ablation of common atrial flutter Ali Erdogan, Joerg Carlsson, Alexander Berkowitsch, Britta Schulte, Joerg Neuzner, Heinz F. Pitschner. Kerckhoff Heart Center, Dept. of Cardiology, Bad Nauheim, Germany
Journal: Journal of the American College of Cardiology (2001)
Correction to: Terminal weaning or immediate extubation for withdrawing mechanical ventilation in critically ill patients (the ARREVE observational study)
Authors: René Robert, Amélie Le Gouge, Nancy Kentish-Barnes, Alice Cottereau, Bruno Giraudeau, Mélanie Adda, Djillali Annane, Juliette Audibert, François Barbier, Patrick Bardou, Simon Bourcier, Jeremy Bourenne, Alexandre Boyer, François Brenas, Vincent Das, Arnaud Desachy, Jérôme Devaquet, Marc Feissel, Frédérique Ganster, Maïté Garrouste-Orgeas, Guillaume Grillet, Olivier Guisset, Rebecca Hamidfar-Roy, Anne-Claire Hyacinthe, Sebastien Jochmans, Mercé Jourdain, Alexandre Lautrette, Nicolas Lerolle, Olivier Lesieur, Fabien Lion, Philippe Mateu, Bruno Megarbane, Sybille Merceron, Emmanuelle Mercier, Jonathan Messika, Paul Morin-Longuet, Bénédicte Philippon-Jouve, Jean-Pierre Quenot, Anne Renault, Xavier Repesse, Jean-Philippe Rigaud, Ségolène Robin, Antoine Roquilly, Amélie Seguin, Didier Thevenin, Patrice Tirot, Isabelle Vinatier, Elie Azoulay, Jean Reignier
Journal: Intensive Care Medicine (2017)
Deaths and Obituaries.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Familial Dysautonomia
Authors: Johannes Bartels
Journal: JAMA (1970)

Familial dysautonomia is a rare disorder seen almost exclusively in Jewish children. On the basis of past experience, there has been great reluctance to subject these patients to general anesthesia. The principal autonomic disorder that makes anesthesia dangerous appears to be a lack of endogenous catecholamine when the stress of anesthesia or surgery or both calls for this substance. In the case described here, carefully titrated exogenous epinephrine was a decisive factor in the successful management of anesthesia for major thoracic surgery.
No evidence for increased cell entry or antibody evasion by Delta sublineage AY.4.2
Authors: Prerna Arora, Amy Kempf, Inga Nehlmeier, Luise Graichen, Martin S. Winkler, Martin Lier, Sebastian Schulz, Hans-Martin Jäck, Stefan Pöhlmann, Markus Hoffmann
Journal: Cellular and Molecular Immunology (2022)

Since the beginning of the COVID-19 pandemic, multiple SARS-CoV-2 variants have emerged. While some variants spread only locally, others, referred to as variants of concern, disseminated globally and became drivers of the pandemic. All SARS-CoV-2 variants harbor mutations relative to the virus circulating early in the pandemic, and mutations in the viral spike (S) protein are considered of particular relevance since the S protein mediates host cell entry and constitutes the key target of the neutralizing antibody response. As a consequence, mutations in the S protein may increase SARS-CoV-2 infectivity and enable its evasion of neutralizing antibodies. Furthermore, mutations in the S protein can modulate viral transmissibility and pathogenicity.
Cerebral Localization
Journal: Annals of Internal Medicine (1930)

Article1 July 1930Cerebral LocalizationLEWIS J. POLLOCK, M.D.LEWIS J. POLLOCK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-4-1-21 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe importance of the grey matter of the cerebrum was first emphasized by Gall and Spurzheim. The cerebral hemispheres were thought to be divided into as many pairs of particular organs as the functions they subserve.In 1825 G. R. Boullaud described the symptoms of aphasia in a series of cases and was able to show that the frontal lobe was diseased in all cases. A little later (1836) M. Dax demonstrated that cases showing disorders of spoken language suffered from lesions of the left cerebral hemisphere. In 1861 Paul Broca confirmed the conjecture that there was a given center... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*From the Department of Nervous and Mental Diseases, Northwestern University Medical School.**Read at the Meeting of the American College of Physicians, Minneapolis, Minn., February 10, 1930. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1930Volume 4, Issue 1Page: 21-28KeywordsFrontal lobeLesions ePublished: 1 December 2008 Issue Published: 1 July 1930 PDF downloadLoading ...
JAMA Neurology
Authors: Hooman Kamel, New York, Bernard Chang, Dena Dubal, San Francisco, Ari Green, Michael Okun, Florida Gil, D Rabinovici, Kate Denevan, Nancy Hills, Cynthia Armand, Samuel Pleasure, Elan Guterman, Megan Richie, Maulik Shah, Carl Bazil, Alberto Espay, Eva Cincinnati, Ann Feldman, Nathalie Arbor, New Jetté, Ruchira York, Pooja Pittsburgh, Susan Ohio, Berkeley Landau, California Babak, B Navi, Daniel Ontaneda, Stanley Prusiner, Sonja Scholz, Maryland Kenneth, L Tyler, Paul Van Ness, Denise Steinhauser, Joe Wixted, Ahmed Avendano, Kim Boler, Rhonda Brown, Fin Carter, Michael Deegan, Daniel Degroot, Euwanaha Joiner-Smith, Joshua Lane, Cindy Rendlen, Ellen Yoshihara, Annissa Zak, Circulation Services, Julie Burton, Ronna Hewitt, Mary Sieck, Geneine Someren, Jamaal Vargas, Content Systems, Mike Bujewski, Nathan Mitre, Digital Production, Regina Brownlee, Amanda Camino, Brenda Chandler-Grayer, Emily Dunn, Amy Evers, Maleeka Holden, Teri Hutchison, Dan Knowles, Joshua Lampinen, Natalie Marsh, Patricia Panek, Marla Seidell, La Son, Diggs Sledge, Julian Graphics, Joe Amft, James Collver, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski, Proofreading Carol, Joy Farrell, Maria Giannini, Sasha Grossman, Judith Literskis, Teresa Omiotek, Michael Ryder, James Madara, Howard Bauchner, S Josephson
Journal: JAMA Neurology (2021)

The mission of JAMA Neurology is to publish scientifi c information primarily important for those physicians caring for people with neurologic disorders but also for those interested in the structure and function of the normal and diseased nervous system.These specifi c aims are (1) to make timely publication of original research of the nervous system, (2) to record observations of single patients or groups of patients that will provide new information and insights,(3) to report more basic research that is pertinent to the understanding of disease, (4) to introduce topics of practice, ethics, teaching, and history that are useful, and (5) to provide a forum for discussion on topics that may be controversial in this fi eld.This information will be published only after extensive peer review so that originality, clarity, and precision are ensured.
TCT-16 Prospective, Multi-Center Evaluation of the DESolve Novolimus-Eluting Bioresorbable Coronary Scaffold: Imaging Outcomes and 5-Year Clinical and Imaging Results
Authors: Stefan Verheye, Joachim Schofer, Michael Maeng, Carsten Skurk, Roberto Botelho, J. Ribamar Costa, Daniel Chamie, Juliana Castro, Andrea Abizaid, John Yan, Lynn Morrison, Vinayak Bhat, Sara Toyloy, Alexandre Abizaid
Journal: Journal of the American College of Cardiology (2017)
Long-term outcome and cost-effective of stenting versus balloon angioplasty in selected patients with acute myocardial infarction Jan Paul Ottervanger, Harry Suryapranata, Edwin Nibbering, Arnoud W.J. van't Hof, Jan C. A. Hoorntje, Menko jan de Boer, Maywen Al, Felix Zijlstra. Isala Klinieken, hospital De Weezenlanden, Zwolle, The Netherlands
Journal: Journal of the American College of Cardiology (2001)
Age-related changes in A-V conduction in connexin-40 deficient mice Wei Zhu, Samir Saba, Caterina Sellitto, David L. Paul, Brian VanderBrink, Mark S. Link, Munther K. Homoud, N. A. Mark Estes, III, Paul J. Wang. New England Medical Center, Boston, MA, Harvard Medical School, Boston, MA
Journal: Journal of the American College of Cardiology (2001)