tbuckley/cabot-search huggingface dataset:
Biomimetic nanoparticles directly remodel immunosuppressive microenvironment for boosting glioblastoma immunotherapy
Authors: Tingting Wang, Hao Zhang, Weibao Qiu, Yaobao Han, Hanghang Liu, Zhen Li
Journal: Bioactive Materials (2022)

Glioblastoma (GBM), as a very aggressive cancer of central nervous system, is very challenging to completely cure by the conventional combination of surgical resection with radiotherapy and chemotherapy. The success of emerging immunotherapy in hot tumors has attracted considerable interest for the treatment of GBM, but the unique tumor immunosuppressive microenvironment (TIME) of GBM leads to the failure of immunotherapy. Here, we show the significant improvement of the immunotherapy efficacy of GBM by modulating the TIME through novel all-in-one biomimetic nanoparticles (i.e. CS-I/J@CM NPs). The nanoparticles consist of utrasmall Cu2-x Se nanoparticles (NPs) with outstanding intrinsic properties (e.g., photo-responsive Fenton-like catalytic property for inducing immunogenic cell death (ICD) and alleviating the hypoxia of tumor), indoximod (IND, an inhibitor of indoleamine-2,3-dioxygenease in tumor), JQ1 (an inhibitor for reducing the expression of PD-L1 by tumor cells), and tumor cell membrane for improving the targeting capability and accumulation of nanoparticles in tumor. We reveal that these smart CS-I/J@CM NPs could drastically activate the immune responses through remodeling TIME of GBM by multiple functions. They could (1) increase M1-phenotype macrophages at tumor site by promoting the polarization of tumor-associated macrophages through the reactive oxygen species (ROS) and oxygen generated from the Fenton-like reaction between nanoparticles and H2O2 within tumor under NIR II irradiation; (2) decrease the infiltration of Tregs cells at tumor site through the release of IND; (3) decrease the expression of PD-L1 on tumor cells through JQ1. The notable increments of anti-tumor CD8+T cells in the tumor and memory T cells (TEM) in the spleen show excellent therapy efficacy and effectively prevent the recurrence of GBM after modulation of the TIME. This work demonstrates the modulation of TIME could be a significant strategy to improve the immunotherapy of GBM and other cold tumors.
Ebola in DR Congo: getting the job done
Authors: None The Lancet
Journal: The Lancet (2020)

With the world's focus on the coronavirus disease 2019 (COVID-19) outbreak, a good news story receiving far less attention is that of Semida Masika, the last person in DR Congo confirmed to have Ebola virus infection and discharged from care after her recovery on March 4. This important milestone is a remarkable achievement given the insecurity in DR Congo, which led to serious attacks on health-care facilities, workers, and patients, and a continual disabling of the outbreak response.
Hot weather and heat extremes: health risks
Authors: Kristie L Ebi, Anthony Capon, Peter Berry, Carolyn Broderick, Richard de Dear, George Havenith, Yasushi Honda, R Sari Kovats, Wei Ma, Arunima Malik, Nathan B Morris, Lars Nybo, Sonia I Seneviratne, Jennifer Vanos, Ollie Jay
Journal: The Lancet (2021)
Long-term outcomes of rectal neuroendocrine tumors according to the risk after endoscopic resection: A multicenter study.
Authors: Hyun Jin Lee, Han Hee Lee, Ilsoo Kim, Yun Seo, Hana Jung, Chang Kyo Oh, Ji Min Lee, Hyun Ho Choi, Tae-Geun Gweon, Sung Hak Lee, Dae Young Cheung, Jin Il Kim, Soo-Heon Park
Journal: Journal of Clinical Oncology (2022)

505 Background: The detection of rectal neuroendocrine tumors has increased with advances in diagnostic endoscopy. Endoscopic resection (ER) is highly effective treatment option for small rectal neuroendocrine tumors (NETs) confined to submucosa. However, there was no risk classification for evaluating the clinical outcomes. In this study, we analyzed long-term outcomes of rectal neuroendocrine tumors after ER. Methods: In this multicenter retrospective study, we analyzed the medical records of patients who underwent ER of rectal NETs from 2009 to 2018 and were followed for ≥ 12 months at five university hospitals under the Catholic Central Medical Center in Korea. Data were collected through Catholic Medical Center Clinical Data Warehouse. We classified patients into three risk groups (low, intermediate, an high) according to clinicopathologic status of rectal NETs. The high-risk group was defined if the tumors have any of the followings: size ≥ 10mm, lymphovascular invasion, muscularis propria or deeper invasion, positive resection margins, or mitotic count ≥ 2/10. Results: A total of 346 patients were included in our study, with 144 (41.6%), 121 (35.0%), and 81 (23.4%) patients in the low-, intermediate-, and high-risk groups, respectively. Among the high-risk group, only seven patients (7/81, 8.6%) received salvage treatment at 2.1 ± 4.1 months after initial treatment. Of them, three patients underwent endoscopic submucosal dissection and the other four patients underwent surgery. There was no extracolonic metastasis in all 7 patients. During follow-up period of all included patients, although there was no local recurrence, four patients (4/346, 1.1%) had extracolonic metastasis (2 liver, 2 perirectal lymph node) at 70.5 ± 33.9 months after initial treatment. Three of them (75%) were high-risk patients without salvage treatment. The risk of extracolonic metastasis is significantly higher in the high-risk group compared with the others (P=0.041, Fisher exact test). Conclusions: Although the prognosis of the patients who underwent ER of rectal NETs showed favorable outcomes, physicians should be concerned with the possibility of metastasis during long-term follow-up of high-risk patients and consider salvage treatment.
An Address on the Law of Murder in its Medical Aspects
Authors: J. C. Bucknill
Journal: BMJ (1874)

When my fi-icnd Dr. Crichton Brownie did me the great hioniour to ask ie to read the Annual Address on this occasioni, he assure(l miie that I slhould have a highlly appreciative, that is to say, a highly critical, audienice ; and that it would be well to bear in mind that this auclience would niot be composed of specialists.As my own studies lhave run much in the groove of the absorbing and important spe- cialty, of wsvhich tlis noble institution is not only a great instrument, but, under the energetic direction of Dr. Browne has become beyond all such institutions a school of observation and a college of instruction, it was somewhat dlifficult to choose a subject wvhich should be appro- priate to this place and yet not be too special.My thoughts not un- niaturally reverted to a question on w7hich I lhad written twventy years ago, and the difficuLlties of shich have certainly not been removed by the great attentioin which it has since attracted, namely, the responsibility of the insanie for criminal actions.This questioni, however, if not entirely, does mainly, and in by far the greater numiber of instances, present itself with reference to onle criminal act-the greatest and most fearful, and yet, perhaps, the simplest by svhicli society can be wvounded-namely, the illegal taking of hluman life, und(ler whatever lname it may be expressed, murder, man- slaughter, infanticide, and homicide by negligence.In looking for the grounds of responsibility for this great crime, and the reasons w!hich ought to be valicl for excuLsing it, one cannot fail to be impressed by the vast interest and importance which the wlhole subject of homicide, its varieties, conditions, alnd consequences, possesses for all the members of our profession.The question of the irresponsibility of the insane is but a portion of this subject ; its most difficult and unsettled portion, it is true.But all the causes and coia(litions of violent death essentially appertain to our department of klnowledge, and the lawv can seldom be put in force in such matters, unless judcge and jury be instructed and guided by medical evidence.WVe are the ctistodiains of the golden bowvl of life, and, svhen it is broken by violent handIs, w e are invariably called upon to describe and explain the catastropphe.
A Man in His 60s With Severe Heart Failure and Incessant Ventricular Arrhythmias
Authors: Karim Benali, Vincent Galand, Raphaël Martins
Journal: JAMA Cardiology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Effecto de Helium e le Rar Gases super Crescimento Cellular
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ADVANTAGE OF SENDING QUESTIONNAIRES IN DUPLICATE
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A novel drug-delivery stent: Intravascular ultrasound observations from the first human experience with the QUANAM QuaDS-QP2 stent system Yasuhiro Honda, Eberhard Grube, Luis M. de la Fuente, Paul G. Yock, Peter J. Fitzgerald, Simon H. Stertzer. Stanford University, Stanford, CA
Journal: Journal of the American College of Cardiology (2001)
THURSDAY 10TH SEPTEMBER
Authors: J Dillon, R Grose, J Nolan, A Bouchier, C Hayes, Baron Misiewicz, Boyd Ejs
Journal: Gut (1992)

Stress induced Catecholamine rises are a vital survival response.We studied the effect of exercise and autonomic (ANS) dysfunction on Noradrenaline (NA) responses in cirrhosis.21 patients (mean age 54; M:F, 14:7; 11 alcoholic, 9 PBC, 1 hepatitis; 9 Childs A, 8 B and 3 C) were exercised on a bicycle ergometer.NA was measured at rest and at peak exercise.ANS function was assessed by standard CVS reflex tests.densitometric units.Results: After eradication of HP the median somatostatin mRNA level increased from 50 (25-160, range) to 95 (40-180), P < 0.02.Gastrin mRNA levels were not significantly changed from 32 (19-217) before to 42 (7-118) after treatment.Conclusion: HP infection in duodenal ulcer patients is associated with decreased antral somatostatin mRNA.This may explain the abnormalities of gastric physiology seen in these patients.
Colonic endoscopic submucosal dissection using a novel robotic system.
Authors: Sang Hyun Kim, Hyuk Soon Choi, Jae Min Lee, Eun Sun Kim, Bora Keum, Yoon Tae Jeen, Hong Sik Lee, Hoon Jai Chun, Junghyun Im, Daehie Hong, Byung Gon Kim
Journal: Journal of Clinical Oncology (2022)

111 Background: Appropriate tissue tension and clear visibility of the dissection area using traction are essential for effective and safe endoscopic submucosal dissection (ESD). We developed a robotic assistive traction device for colonoscopy.This is a preclinical animal study to evaluate the performance of colorectal ESD using novel robotic system. Methods: Experienced endoscopist performed ESD on ex vivo porcine colon ten times using a robot and ten times by the conventional method. The outcome measures were operating time (from starting incision to finishing dissection), completeness of resection, procedure-related adverse events, and limitations of arm manipulation in a narrow working space as assessed by counting the frequency of blind cutting.We also conducted an in vivo feasibility study on live pig. Results: Total of twenty colonic lesions were resected from ex vivo porcine colon. The submucosal dissection speed was significantly faster in robotic ESD than in conventional ESD (P = 0.002). Adverse events such as perforation were also significantly higher in the conventional group. In the in vivo feasibility study, robot was attached to the colonoscope and inserted into the proximal colon. ESD was performed successfully. Conclusions: When the robot was assisting in the ESD procedure, the dissection speed improved significantly. Our robotic device can thus provide simple, effective, and safe multidirectional traction during colonic ESD.
Endobronchial Clear-Cell Sugar Tumor
Authors: Chang-Hui Xiao, Xian-Zheng Tan, Gong-Xun Xie, Peng Liu, Jian-Bin Liu
Journal: American Journal of Respiratory and Critical Care Medicine (2021)

"Endobronchial Clear-Cell Sugar Tumor." American Journal of Respiratory and Critical Care Medicine, 204(12), pp. 1476–1477
Tissue factor expression in atrial myocarditis associated with nonrheumatic atrial fibrillation: A possible cause of cardiogenic thromboembolism Yoichi Nakamura, Kengo Kusano, Kazufumi Nakamura, Tetsuro Emori, Hiroshi Morita, Chikao Yutani, Tsutomu Hamuro, Hiromi Matsubara, Tohru Ohe. Okayama University Medical School, Okayama, Japan, National Cardiovascular Center, Osaka, Japan
Journal: Journal of the American College of Cardiology (2001)
Isolation and inclusion
Authors: None The Lancet Psychiatry
Journal: The Lancet Psychiatry (2020)

The COVID-19 crisis will touch the life of everyone in some way. While viral transmission, incubation times, and care of severely affected patients rightly dominate the news, it is heartening that mental health is given plenty of airtime. Symptoms of anxiety and depression are to be expected in times of stress. Concerns more specific to the COVID-19 outbreak that might have more lasting consequences are the features that prevent health-care staff, carers, and families from having personal contact with patients: working from behind a mask, limiting physical interaction, and not being able to visit ill relatives.
Stroke Prevention in Atrial Fibrillation
Authors: Aristeidis H Katsanos, Hooman Kamel, Jeff S. Healey, Robert G. Hart
Journal: Circulation (2020)

Ischemic strokes related to atrial fibrillation are highly prevalent, presenting with severe neurologic syndromes and associated with high risk of recurrence. Although advances have been made in both primary and secondary stroke prevention for patients with atrial fibrillation, the long-term risks for stroke recurrence and bleeding complications from antithrombotic treatment remain substantial. We summarize the major advances in stroke prevention for patients with atrial fibrillation during the past 30 years and focus on novel diagnostic and treatment approaches currently under investigation in ongoing clinical trials. Non–vitamin K antagonist oral anticoagulants have been proven to be safer and equally effective compared with warfarin in stroke prevention for patients with nonvalvular atrial fibrillation. Non–vitamin K antagonist oral anticoagulants are being investigated for the treatment of patients with atrial fibrillation and rheumatic heart disease, for the treatment of patients with recent embolic stroke of undetermined source and indirect evidence of cardiac embolism, and in the prevention of vascular-mediated cognitive decline in patients with atrial fibrillation. Multiple clinical trials are assessing the optimal timing of non–vitamin K antagonist oral anticoagulant initiation after a recent ischemic stroke and the benefit:harm ratio of non–vitamin K antagonist oral anticoagulant treatment in patients with atrial fibrillation and history of previous intracranial bleeding. Ongoing trials are addressing the usefulness of left atrial appendage occlusion in both primary and secondary stroke prevention for patients with atrial fibrillation, including those with high risk of bleeding. The additive value of prolonged cardiac monitoring for subclinical atrial fibrillation detection through smartphone applications or implantable cardiac devices, together with the optimal medical management of individuals with covert paroxysmal atrial fibrillation, is a topic of intensive research interest. Colchicine treatment and factor XIa inhibition constitute 2 novel pharmacologic approaches that might provide future treatment options in the secondary prevention of cardioembolic stroke attributable to atrial fibrillation.
Determinants of mortality from Co-morbid conditions in a population based follow-up of 39,710 newly diagnosed heart failure patients in Ontario, Canada Erika Vowinckel, Philip Jong, Peter Liu, Jack Tu. Heart &amp; Stroke/Richard Lewar Centre of Excellence, Toronto, ON, Canada, Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
Journal: Journal of the American College of Cardiology (2001)
Emil Kraepelin (1856-1926). Psychiatric nosographer
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Infection Fatality Ratios for COVID-19 Among Noninstitutionalized Persons 12 and Older
Journal: Annals of Internal Medicine (2020)

Corrections20 October 2020Correction: Infection Fatality Ratios for COVID-19 Among Noninstitutionalized Persons 12 and OlderFREEThis correction concerns the following article:LettersJan 2021Infection Fatality Ratios for COVID-19 Among Noninstitutionalized Persons 12 and Older: Results of a Random-Sample Prevalence StudyFREEJustin Blackburn, PhD, Constantin T. Yiannoutsos, PhD, Aaron E. Carroll, MD, MS, Paul K. Halverson, DrPH, and Nir Menachemi, PhD, MPHJustin Blackburn, PhDIndiana University Richard M. Fairbanks School of Public Health, Indianapolis, Indiana (J.B., C.T.Y., P.K.H., N.M.), Constantin T. Yiannoutsos, PhDIndiana University Richard M. Fairbanks School of Public Health, Indianapolis, Indiana (J.B., C.T.Y., P.K.H., N.M.), Aaron E. Carroll, MD, MSIndiana University School of Medicine, Indianapolis, Indiana (A.E.C.), Paul K. Halverson, DrPHIndiana University Richard M. Fairbanks School of Public Health, Indianapolis, Indiana (J.B., C.T.Y., P.K.H., N.M.), and Nir Menachemi, PhD, MPHIndiana University Richard M. Fairbanks School of Public Health, Indianapolis, Indiana (J.B., C.T.Y., P.K.H., N.M.)https://doi.org/10.7326/L20-1152 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In the article by Blackburn and colleagues (1), corrections were made to the calculations in the Table. These corrections were made to the online version on 3 September 2020.Reference1. Blackburn J, Yiannoutsos CT, Carroll AE, et al. Infection fatality ratios for COVID-19 among noninstitutionalized persons 12 and older: results of a random-sample prevalence study [Letter]. Ann Intern Med. 2020. [PMID: 32877214]. doi:10.7326/M20-5352 LinkGoogle Scholar Comments 0 Comments Sign In to Submit A Comment PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoInfection Fatality Ratios for COVID-19 Among Noninstitutionalized Persons 12 and Older: Results of a Random-Sample Prevalence Study Justin Blackburn , Constantin T. Yiannoutsos , Aaron E. Carroll , Paul K. Halverson , and Nir Menachemi Metrics 20 October 2020Volume 173, Issue 8 Page: 684 Keywords COVID-19 ePublished: 20 October 2020 Issue Published: 20 October 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...