tbuckley/cabot-search huggingface dataset:
TCT-115 Complex Versus Noncomplex Percutaneous Coronary Intervention With Newer-Generation Drug-Eluting Stents: An Analysis From the Randomized BIOFLOW Trials
Authors: Rayyan Hemetsberger, Mohammad Abdelghani, Ralph Toelg, Hector Garcia-Garcia, Serdar Farhan, Karim Elbasha, Abdelhakim Allali, Stephan Windecker, Thierry Lefevre, Shigeru Saito, David Kandzari, Ron Waksman, Gert Richardt
Journal: Journal of the American College of Cardiology (2021)
Analysis of Sociodemographic, Clinical, and Genomic Factors Associated With Breast Cancer Mortality in the Linked Surveillance, Epidemiology, and End Results and Medicare Database
Authors: Timothy J. Robinson, Lauren E. Wilson, P. Kelly Marcom, Melissa Troester, Charles F. Lynch, Brenda Y. Hernandez, Edgardo Parrilla, Heather Ann Brauer, Michaela A. Dinan
Journal: JAMA Network Open (2021)

Understanding interactions among health service, sociodemographic, clinical, and genomic factors in breast cancer disparities research has been limited by a disconnect between health services and basic biological approaches.
Genome-Wide Reconstruction of Rediploidization Following Autopolyploidization across One Hundred Million Years of Salmonid Evolution
Authors: Manu Kumar Gundappa, Thu-Hien To, Lars Grønvold, Samuel A M Martin, Sigbjørn Lien, Juergen Geist, David Hazlerigg, Simen R Sandve, Daniel J Macqueen
Journal: Molecular Biology and Evolution (2021)

The long-term evolutionary impacts of whole-genome duplication (WGD) are strongly influenced by the ensuing rediploidization process. Following autopolyploidization, rediploidization involves a transition from tetraploid to diploid meiotic pairing, allowing duplicated genes (ohnologs) to diverge genetically and functionally. Our understanding of autopolyploid rediploidization has been informed by a WGD event ancestral to salmonid fishes, where large genomic regions are characterized by temporally delayed rediploidization, allowing lineage-specific ohnolog sequence divergence in the major salmonid clades. Here, we investigate the long-term outcomes of autopolyploid rediploidization at genome-wide resolution, exploiting a recent "explosion" of salmonid genome assemblies, including a new genome sequence for the huchen (Hucho hucho). We developed a genome alignment approach to capture duplicated regions across multiple species, allowing us to create 121,864 phylogenetic trees describing genome-wide ohnolog divergence across salmonid evolution. Using molecular clock analysis, we show that 61% of the ancestral salmonid genome experienced an initial "wave" of rediploidization in the late Cretaceous (85-106 Ma). This was followed by a period of relative genomic stasis lasting 17-39 My, where much of the genome remained tetraploid. A second rediploidization wave began in the early Eocene and proceeded alongside species diversification, generating predictable patterns of lineage-specific ohnolog divergence, scaling in complexity with the number of speciation events. Using gene set enrichment, gene expression, and codon-based selection analyses, we provide insights into potential functional outcomes of delayed rediploidization. This study enhances our understanding of delayed autopolyploid rediploidization and has broad implications for future studies of WGD events.
The Usefulness of Serum Hepcidin Measurement in Chronic Heart Failure
Authors: Akahori K, Sakoda T, Ohyanagi M, Tomosugi N, Masuyama T, Yoshida C, Goda A, Nakao S, Matsumoto M, Tsujino T, Lee-Kawabata M, Naito Y, Ezumi A
Journal: Circulation (2008)
ジョージア州アトランタ,米国における男性と性的関係を持つ男性におけるHIV有病率における人種的格差の源:モデル化研究【Powered by NICT】
Authors: Goodreau Steven M, Rosenberg Eli S, Jenness Samuel M, Luisi Nicole, Stansfield Sarah E, Millett Gregorio A, Sullivan Patrick S
Journal: The Lancet HIV (2017)
Dynamic SARS-CoV-2-specific B-cell and T-cell responses following immunization with an inactivated COVID-19 vaccine
Authors: Yuxin Chen, Shengxia Yin, Xin Tong, Yue Tao, Jun Ni, Jie Pan, Ming Li, Yawen Wan, Minxin Mao, Yali Xiong, Xiaomin Yan, Yue Yang, Rui Huang, Chao Wu, Han Shen
Journal: Clinical Microbiology and Infection (2021)
Development and validation of the PORTRET tool to predict recurrence, overall survival, and other-cause mortality in older patients with breast cancer in the Netherlands: a population-based study
Authors: Willeke G van der Plas-Krijgsman, Daniele Giardiello, Hein Putter, Ewout W Steyerberg, Esther Bastiaannet, Anne M Stiggelbout, Simon P Mooijaart, Judith R Kroep, Johanneke E A Portielje, Gerrit-Jan Liefers, Nienke A de Glas
Journal: The Lancet Healthy Longevity (2021)

<h2>Summary</h2><h3>Background</h3> Current prediction tools for breast cancer outcomes are not tailored to the older patient, in whom competing risk strongly influences treatment effects. We aimed to develop and validate a prediction tool for 5-year recurrence, overall mortality, and other-cause mortality for older patients (aged ≥65 years) with early invasive breast cancer and to estimate individualised expected benefits of adjuvant systemic treatment. <h3>Methods</h3> We selected surgically treated patients with early invasive breast cancer (stage I–III) aged 65 years or older from the population-based FOCUS cohort in the Netherlands. We developed prediction models for 5-year recurrence, overall mortality, and other-cause mortality using cause-specific Cox proportional hazard models. External validation was performed in a Dutch Cancer registry cohort. Performance was evaluated with discrimination accuracy and calibration plots. <h3>Findings</h3> We included 2744 female patients in the development cohort and 13631 female patients in the validation cohort. Median age was 74·8 years (range 65–98) in the development cohort and 76·0 years (70–101) in the validation cohort. 5-year follow-up was complete for more than 99% of all patients. We observed 343 and 1462 recurrences, and 831 and 3594 deaths, of which 586 and 2565 were without recurrence, in the development and validation cohort, respectively. The area under the receiver-operating-characteristic curve at 5 years in the external dataset was 0·76 (95% CI 0·75–0·76) for overall mortality, 0·76 (0·76–0·77) for recurrence, and 0·75 (0·74–0·75) for other-cause mortality. <h3>Interpretation</h3> The PORTRET tool can accurately predict 5-year recurrence, overall mortality, and other-cause mortality in older patients with breast cancer. The tool can support shared decision making, especially since it provides individualised estimated benefits of adjuvant treatment. <h3>Funding</h3> Dutch Cancer Foundation and ZonMw.
DNA Methylation Profiling: An Emerging Paradigm for Cancer Diagnosis
Authors: Antonios Papanicolau-Sengos, Kenneth Aldape
Journal: Annual Review of Pathology Mechanisms of Disease (2021)

Histomorphology has been a mainstay of cancer diagnosis in anatomic pathology for many years. DNA methylation profiling is an additional emerging tool that will serve as an adjunct to increase accuracy of pathological diagnosis. Genome-wide interrogation of DNA methylation signatures, in conjunction with machine learning methods, has allowed for the creation of clinical-grade classifiers, most prominently in central nervous system and soft tissue tumors. Tumor DNA methylation profiling has led to the identification of new entities and the consolidation of morphologically disparate cancers into biologically coherent entities, and it will progressively become mainstream in the future. In addition, DNA methylation patterns in circulating tumor DNA hold great promise for minimally invasive cancer detection and classification. Despite practical challenges that accompany any new technology, methylation profiling is here to stay and will become increasingly utilized as a cancer diagnostic tool across a range of tumor types.
TCT-385 Prognostic Impact of Nutritional Status After Transcatheter Edge-to-Edge Mitral Valve Repair: The MIVNUT Registry
Authors: Berenice Caneiro-Queija, Sergio Raposeiras Roubin, Marianna Adamo, Xavier Freixa, Dabit Arzamendi, Isaac Pascual, Luis Nombela Franco, Antonio Portolés Hernández, Cosmo Godino, Andres Iñiguez Romo, Rodrigo Estevez-Loureiro
Journal: Journal of the American College of Cardiology (2021)
TCT-433 US Trends in TAVR Procedures and Outcomes Among Patients With Histories of Atrial Fibrillation
Authors: Michael Fatuyi, Leanne Pereira, Vahid Namdarizandi, Awfa Zain Elabidin, Vivek Sharma, Emmanuel Akuna, Oluwasegun Akinti, Olukayode Busari, Kamal Shemisa
Journal: Journal of the American College of Cardiology (2021)
Isavuconazole is highly active in vitro against Candida species isolates but shows trailing effect
Authors: Laura Judith Marcos-Zambrano, Ana Gómez, Carlos Sánchez-Carrillo, Emilio Bouza, Patricia Muñoz, Pilar Escribano, Jesús Guinea
Journal: Clinical Microbiology and Infection (2020)

Isavuconazole is a triazole previously shown to have potent in vitro activity against Aspergillus spp., Mucorales, and Candida spp. Unlike for other azoles, it is unclear if isavuconazole may induce a trailing effect. We studied isavuconazole MICs for a large collection of Candida isolates from blood samples and determined the extent of the trailing effect when using the EUCAST Edef 7.3.1 method.761 molecularly identified Candida isolates from blood samples of 742 patients admitted to the hospital (January 2007 to September 2017) were evaluated and further tested for in vitro susceptibility to isavuconazole following the EUCAST E.Def 7.3.1 test method.C. albicans showed the highest susceptibility, followed by C. parapsilosis and C. tropicalis (geometric mean MIC 0.003 vs 0.005/0.006, respectively; P < 0.001). In contrast, C. glabrata, and C. krusei had significantly higher MIC values (geometric mean MIC 0.094 vs 0.093, respectively). Isavuconazole MIC distributions were not truncated at the lowest concentration tested, except for C. albicans. Overall, the mean percentage of trailing was 12.9% but differences among species were observed: C. glabrata, C. albicans, and C. tropicalis exhibited higher trailing in comparison to C. parapsilosis and non-Candida yeasts (P < 0.001). The percentage of non-wild-type C. albicans (considering the heavy trailer isolates as wild-type), C. parapsilosis and C. glabrata isolates were 0.56% (2/355), 1.5% (3/200), and 4.65% (4/86), respectively.Isavuconazole showed high in vitro activity against Candida spp., particularly against C. albicans. Trailing effect is commonly observed with isavuconazole, particularly with C. glabrata.
TCT-491 Nocturnal Blood Pressure Fall Can Predict and Evaluate the Effect of Renal Denervation on Diastolic Function in Patients With Resistant Hypertension and Type 2 Diabetes Mellitus
Authors: Musheg Manukyan, Alla Falkovskaya, Stanislav Pekarskiy, Irina Zyubanova, Ekaterina Tsoi, Valeria Lichikaki, Tamara Ryabova, Viktor Mordovin
Journal: Journal of the American College of Cardiology (2021)
Waiting for Cardiac Surgery
Authors: A. Andrew Ray, Karen J. Buth, John A. Sullivan, David E. Johnstone, Gregory M. Hirsch
Journal: Circulation (2001)

Background The Queen Elizabeth II Health Sciences Centre uses a weekly peer-review conference of cardiovascular experts to prioritize each surgical case to 1 of 4 queues with the use of standardized criteria of coronary anatomy, stress test result, and symptoms. We examined the hazard of waiting as well as the impact of waiting on surgical outcomes. Methods and Results Analysis was performed for 2102 consecutive patients queued for CABG, aortic valve replacement, or CABG+aortic valve replacement between January 1, 1998, and December 31, 1999. Among 1854 patients undergoing surgery, median waiting times on the respective queues were as follows: in-house urgent group, 8 days; semiurgent A group, 37 days; semiurgent B group, 64 days; and elective group, 113 days. There were 13 deaths (12 cardiac) that occurred during the waiting period (0.7% of the patients). Of the 8.7% patients upgraded to a more urgent queue, 86.1% required hospitalization before surgery. Although female sex was not associated with prolonged waiting time, it was predictive of urgent status ( P =0.001). The incidence of postoperative complications was 25.0%, and operative mortality was 2.86%. Both were more frequent among patients undergoing surgery early ( P =0.01); however, this difference was attributable to the in-house urgent queue. The median length of stay was 7 days for all patients and was not affected by waiting time. Conclusions Death and upgrades while the patients were waiting tended to occur early in the queuing process, and prolonged waiting was not associated with worse surgical outcomes. The cost of reducing waiting times could in part be offset by prevention of hospital admissions among upgraded patients.
Fabrication of physical and chemical crosslinked hydrogels for bone tissue engineering
Authors: Xu Xue, Yan Hu, Sicheng Wang, Xiao Chen, Yingying Jiang, Jiacan Su
Journal: Bioactive Materials (2021)

Bone tissue engineering has emerged as a significant research area that provides promising novel tools for the preparation of biomimetic hydrogels applied in bone-related diseases (e.g., bone defects, cartilage damage, osteoarthritis, etc.). Herein, thermal sensitive polymers (e.g., PNIPAAm, Soluplus, etc.) were introduced into main chains to fabricate biomimetic hydrogels with injectability and compatibility for those bone defect need minimally invasive surgery. Mineral ions (e.g., calcium, copper, zinc, and magnesium), as an indispensable role in maintaining the balance of the organism, were linked with polymer chains to form functional hydrogels for accelerating bone regeneration. In the chemically triggered hydrogel section, advanced hydrogels crosslinked by different molecular agents (e.g., genipin, dopamine, caffeic acid, and tannic acid) possess many advantages, including extensive selectivity, rapid gel-forming capacity and tunable mechanical property. Additionally, photo crosslinking hydrogel with rapid response and mild condition can be triggered by different photoinitiators (e.g., I2959, LAP, eosin Y, riboflavin, etc.) under specific wavelength of light. Moreover, enzyme triggered hydrogels were also utilized in the tissue regeneration due to its rapid gel-forming capacity and excellent biocompatibility. Particularly, some key factors that can determine the therapy effect for bone tissue engineering were also mentioned. Finally, brief summaries and remaining issues on how to properly design clinical-oriented hydrogels were provided in this review.
Progress Toward Global Eradication of Dracunculiasis, January 2020–June 2021
Authors: Donald R. Hopkins, Adam J. Weiss, Sharon L. Roy, Sarah Yerian, Vitaliano A. Cama
Journal: MMWR Morbidity and Mortality Weekly Report (2021)

Dracunculiasis (Guinea worm disease), caused by the parasite Dracunculus medinensis, is traditionally acquired by drinking water containing copepods (water fleas) infected with D. medinensis larvae, but in recent years also appears increasingly to be transmitted by eating fish or other aquatic animals. The worm typically emerges through the skin on a lower limb of the host 1 year after infection, causing pain and disability (1). There is no vaccine or medicine to prevent or medicine to treat dracunculiasis; eradication relies on case containment* to prevent water contamination and other interventions to prevent infection: health education, water filtration, treatment of unsafe water with temephos (an organophosphate larvicide), and provision of safe drinking water (1,2). The eradication campaign began in 1980 at CDC (1). In 1986, with an estimated 3.5 million cases
An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury
Authors: Brett J. Hilton, Andreas Husch, Barbara Schaffran, Tien-chen Lin, Emily R. Burnside, Sebastian Dupraz, Max Schelski, Jisoo Kim, Johannes Alexander Müller, Susanne Schoch, Cordelia Imig, Nils Brose, Frank Bradke
Journal: Neuron (2021)

Axons in the adult mammalian central nervous system fail to regenerate after spinal cord injury. Neurons lose their capacity to regenerate during development, but the intracellular processes underlying this loss are unclear. We found that critical components of the presynaptic active zone prevent axon regeneration in adult mice. Transcriptomic analysis combined with live-cell imaging revealed that adult primary sensory neurons downregulate molecular constituents of the synapse as they acquire the ability to rapidly grow their axons. Pharmacogenetic reduction of neuronal excitability stimulated axon regeneration after adult spinal cord injury. Genetic gain- and loss-of-function experiments uncovered that essential synaptic vesicle priming proteins of the presynaptic active zone, but not clostridial-toxin-sensitive VAMP-family SNARE proteins, inhibit axon regeneration. Systemic administration of Baclofen reduced voltage-dependent Ca
Autopsies trigger dispute over the existence of a novel neurological syndrome in Canada
Authors: Owen Dyer
Journal: BMJ (2021)

Claims that a new degenerative disease lies behind a regional cluster of unexplained neurological symptoms in Canada1 have been dealt a blow after the autopsy reports of eight patients from the cluster in New Brunswick province attributed their deaths to known diseases.

Gerard Jansen, a neuropathologist at the University of Ottawa, presented the abstract of his findings to the Canadian Association of Neuropathologists’ annual meeting in October, and parts of his presentation were passed to the media by unknown sources this week. “In these eight patients no evidence for a prion disease was found, nor novel pathology,” he said.

The deaths were attributed to Alzheimer’s disease, Lewy body dementia, metastatic cancer, frontal lobe dementia, and vascular disease. “We suggest that these eight patients represent a group of misclassified clinical diagnoses,” Jansen concluded, hoping that the findings “will bring some clarity” to a question that has “significantly disturbed the medical community.”

New Brunswick’s health minister Dorothy Shephard told a press conference on 27 …
Abstract 11642: Change in Coronary Artery Calcium (cac) Volume and Density With Direct Plaque Measurements: Findings From the Masala Study
Authors: Alka M Kanaya, Feng Lin, Isac C Thomas, Julie Denenberg, Namratha Kandula, Matthew J Budoff, Michael H Criqui
Journal: Circulation (2019)

Introduction: The Agatston CAC score is a sum of the product of the plaque area and a density score across four coronary arteries, but does not measure CAC volume or density per plaque in each arte...
Updated results from DESTINY-breast01, a phase 2 trial of trastuzumab deruxtecan (T-DXd) in HER2 positive metastatic breast cancer
Authors: Modi, S[Modi, Shanu], Saura, C[Saura, Cristina], Yamashita, T[Yamashita, Toshinari], Park, YH[Park, Yeon Hee], Kim, SB[Kim, Sung-Bae], Tamura, K[Tamura, Kenji], Andre, F[Andre, Fabrice], Iwata, H[Iwata, Hiroji], Ito, Y[Ito, Yoshinori], Tsurutani, J[Tsurutani, Junji], Sohn, J[Sohn, Joohyuk], Denduluri, N[Denduluri, Neelima], Perrin, C[Perrin, Christophe], Aogi, K[Aogi, Kenjiro], Tokunaga, E[Tokunaga, Eriko], Im, SA[Im, Seock-Ah], Lee, KS[Lee, Keun Seok], Hurvitz, SA[Hurvitz, Sara A.], Cortes, J[Cortes, Javier], Lee, C[Lee, Caleb], Liu, YL[Liu, Yali], Zhang, L[Zhang, Lin], Shahidi, J[Shahidi, Javad], Yver, A[Yver, Antoine], Baselga, J[Baselga, Jose], Krop, IE[Krop, Ian E.]
Journal: Cancer Research (2021)
Liposome-based multifunctional nanoplatform as effective therapeutics for the treatment of retinoblastoma
Authors: Ying Liu, Yu Han, Shizhu Chen, Jingjie Liu, Dajiang Wang, Yifei Huang
Journal: Acta Pharmaceutica Sinica B (2021)

Photothermal therapy has the characteristics of minimal invasiveness, controllability, high efficiency, and strong specificity, which can effectively make up for the toxic side effects and tumor resistance caused by traditional drug treatment. However, due to the limited tissue penetration of infrared light, it is difficult to promote and apply in clinical practice. The eye is the only transparent tissue in human, and infrared light can easily penetrate the eye tissue, so it is expected that photothermal therapy can be used to treat fundus diseases. Here in, a new nano-platform assembled by liposome and indocyanine green (ICG) was used to treat retinoblastoma. ICG was assembled in liposomes to overcome some problems of ICG itself. For example, ICG is easily quenched, self-aggregating and instability. Moreover, liposomes can prevent free ICG from being cleared through the systemic circulation. The construction of the nano-platform not only ensured the stability of ICG in vivo, but also realized imaging-guide photothermal therapy, which created a new strategy for the treatment of retinoblastoma.
Self-renewal or quiescence? Orchestrating the fate of mesenchymal stem cells by matrix viscoelasticity via PI3K/Akt-CDK1 pathway
Authors: Chuanchuan Lin, Ye He, Qian Feng, Kun Xu, Zhe Chen, Bailong Tao, Xuemin Li, Zengzilu Xia, Hong Jiang, Kaiyong Cai
Journal: Biomaterials (2021)
Successful Hand Transplantation — One-Year Follow-up
Authors: Jon W. Jones, Scott A. Gruber, John H. Barker, Warren C. Breidenbach
Journal: New England Journal of Medicine (2000)

On the basis of positive results in studies of the transplantation of pig extremities and the information exchanged at an international symposium on composite-tissue transplantation, we developed a protocol for human hand transplantation.
Delivery of STING agonists for adjuvanting subunit vaccines
Authors: Simon Van Herck, Bing Feng, Li Tang
Journal: Advanced Drug Delivery Reviews (2021)

Adjuvant is an essential component in subunit vaccines. Many agonists of pathogen recognition receptors have been developed as potent adjuvants to optimize the immunogenicity and efficacy of vaccines. Recently discovered cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway has attracted much attention as it is a key mediator for modulating immune responses. Vaccines adjuvanted with STING agonists are found to mediate a robust immune defense against infections and cancer. In this review, we first discuss the mechanisms of STING agonists in the context of vaccination. Next, we present recent progress in novel STING agonist discovery and the delivery strategies. We next highlight recent work in optimizing the efficacy while minimizing toxicity of STING agonist-assisted subunit vaccines for protection against infectious diseases or treatment of cancer. Finally, we share our perspectives of current issues and future directions in further developing STING agonists for adjuvanting subunit vaccines.
Computed Tomographic Semiotics of Apical Vertebrae in Patients with Idiopathic Scoliosis Aged from 14 to 18 years, Depending on the Magnitude of Spinal Deformity
Authors: Yu. L. Zejnalov, G. V. Diachkova, A. V. Burtsev, K. A. Diachkov, I. V. Sutyagin, T. A. Larionova
Journal: Radiology - Practice (2021)

Idiopathic scoliosis, as many authors think, being idiopathic in terms of not fully clear etiology of the disease, due to the most complicated long-term studies, has a certain theory of the pathogenesis of scoliosis, which includes the disharmony of the longitudinal growth of the spine and spinal cord and the formation of vertebral torsion. The application of various versions of modern vertebral instrumentation for 20 years made it possible to develop a differentiated approach to the choice of surgical intervention, taking into account the patient’s age and the peculiarities of the deformed spine. Nevertheless, the use of current diagnostic methods indicated that not all the details of the deformed vertebral structure have been studied, in particular the apical ones, that are usually more changed being at the apex of the deformity. The application of multislice computed tomography (MSCT) and current statistical methods made it possible to reveal the structural features of the apical vertebrae in the group of adolescent scoliosis (14–18 years old), that is important for increasing the effectiveness of preoperative planning and improving the results of idiopathic scoliosis treatment being one of the most difficult problems of the spine surgery.