tbuckley/cabot-search huggingface dataset:
Abstract 061: Social Determinants Of Health And Ambulatory Outcomes Among Covid-19 Positive Patients: Differences By Race/ethnicity
Authors: Luisa Alvarez, Ayana K April-Sanders, Un Jung Lee, Ladan Golestaneh, Eran Bellin, Carlos Rodriguez
Journal: Circulation (2022)

Background: COVID-19 has shined a bright light upon the existing socioeconomic and health disparities in the United States. The objective of this study was to assess whether there are racial/ethnic differences in the association between social determinants of health (SDOH) with hospitalization and mortality among COVID+ patients. Methods: We identified a cohort of 505,992 patients receiving ambulatory care at Bronx Montefiore Health System (BMHS) between 1/1/18 and 1/1/20 to evaluate SDOH factors associated with hospitalization (n=2,934) and death (n=748) in a COVID time-period (3/1/20-8/15/20). SDOH indicators were collected from US county-level data from the American Community Survey (ACS), and included percent poverty, education, without insurance, using public transportation, and average household size. Socioeconomic status (SES) index scores were calculated based on the Diez Roux method and reported as standard deviations from New York State mean, with lower scores indicating worse neighborhood-level SES. Ambulatory outcomes included hospitalization and in-hospital mortality (model responses: 1=yes, 0=no). Multivariable logistic regression models were adjusted for age, sex, and comorbidities. Results: Overall, the cohort was comprised of Hispanic (38%), Black (27%), White (6.4%), and Other (26%) racial/ethnic groups with a mean age of 38.5 years (SD=24.6), and 60% female. Of the 1,755 (3.5%) patients who were COVID+ and hospitalized, 24.5% died. The average SES index was -2.39, with best SES among White patients (-1.05) and worst among Hispanic patients (- 3.57). Average % use of public transportation was common among Black (59.5±11.2), Hispanic (62.4±11.6), and Other (60.1±12.8) patients, with lower use among Whites (48.2±15.7). Average household size ranged from 2.6±0.4 persons among Whites to 2.8±0.4 among other racial/ethnic groups. SDOH factors were associated with both hospitalization and mortality among COVID+ patients and varied by race/ethnicity. Among White COVID+ patients, greater use of public transportation was associated with higher odds of hospitalization (OR=1.02, 95% CI: 1.01, 1.04). Greater average household size was associated with lower odds of mortality among Hispanic (OR=0.49, 95% CI: 0.28-0.86) and Other (0.46, 95% CI: 0.23-0.99) COVID+ hospitalized patients but with increased odds of mortality among White COVID+ hospitalized patients (OR=4.30, 95% CI: 1.19-15.56). Conclusions: In-hospital mortality was extremely high during the peak of the COVID period in Bronx, NY. SDOH contributed to hospitalization and mortality among COVID+ patients. Larger average household size may be paradoxically protective against mortality among Hispanics and Others, which did not translate to Whites.
99mTc-MDP Bone Scintigraphy and SPECT/CT of Extensive Subcutaneous Calcification in the Setting of Cosmetic-Induced Lipogranulomatosis
Authors: Karoly Viragh, Mahdi Khoshchehreh, Thomas Zung, Chiayi Ni
Journal: Clinical Nuclear Medicine (2022)

A 56-year-old woman with history of cosmetic buttock augmentation via mineral oil injection 20+ years ago presented with extensive abdominopelvic skin induration and hypercalcemia. The 99mTc-MDP bone scintigraphy performed for hypercalcemia revealed marked heterogeneous radiotracer activity partially obscuring the skeleton. Subsequent SPECT/CT demonstrated that the radiotracer activity was associated with exclusively subcutaneous calcification, the extent of which far exceeded the originally augmented gluteal regions. After extensive workup including tissue biopsy, the final diagnosis was subcutaneous calcification and hypercalcemia secondary to cosmetic injection-related sclerosing lipogranulomatosis, which is a very rare complication of cosmetic augmentation.
Abstract EP09: Empiric Dietary Inflammatory Potential Is Associated With Elevated Left Ventricular Mass
Authors: Rahul V Annabathula, Scott Winsor, Alexandria Sutton, Travis Skipina, Elsayed Z Soliman
Journal: Circulation (2022)

Background: Recent studies have shown associations between proinflammatory diets and several cardiovascular diseases. Whether a proinflammatory diet, assessed using the empirical dietary inflammatory potential (EDIP), is also associated with elevated left ventricular mass index (LVMI) in the general population is unknown. Methods: This analysis included 5,869 participants (55.9 ± 10.5 years; 48.5% male, 71.8% whites) from the Third National Health and Nutrition Examination Survey. EDIP score was calculated from the Food Frequency Questionnaire. LVMI was estimated using a validated electrocardiographic (ECG) model utilizing digitally recorded ECG data, which were processed automatically at a central core laboratory. Elevated left ventricular mass was defined as LVMI values ≥95th percentile (≥149 g/m2). Multivariable logistic regression was used to examine the association between EDIP score (tertiles and per 1-standard deviation (1-SD) increase, separately) and LVMI. Results: In multivariable logistic regression models, each 1-SD increase in EDIP score (0.259) was associated with 25% increased odds of elevated LVMI. Higher odds of elevated LVMI were observed with higher levels (tertiles) of EDIP suggesting a dose-response relationship (Table). These results were consistent in subgroups of the participants stratified by demographics and comorbidities. Conclusions: Dietary patterns with high proinflammatory properties are associated with an elevated LVMI. Given the association between cardiovascular mortality and an elevated LVMI, there needs to be a greater emphasis on the reduction of proinflammatory diet patterns.
All our knowledge begins with the antisenses
Authors: Ethan M. Goldberg
Journal: Journal of Clinical Investigation (2021)

Epilepsy is the neurological disorder defined by spontaneous recurrent seizures, which are abnormal patterns of electrical discharge in the brain. A major advance in neurology over the last 20 years is the identification of genetic variation as an important cause of epilepsy, and in particular as a cause of the epileptic encephalopathies, defined by childhood-onset, treatment-resistant epilepsy accompanied by developmental delay leading to intellectual disability. Unfortunately, this progress in genetic diagnosis has yet to translate to effective precision or targeted therapeutics. However, in this issue of the JCI, Li and Jancovski et al. use antisense oligonucleotides (ASO) to treat or prevent epilepsy and epilepsy-associated cognitive and behavioral comorbidities in a mouse model of SCN2A encephalopathy, paralogous to the recurrent human variant SCN2A c.5645G>A (p.R1882Q) associated with epileptic encephalopathy. These findings may inform the development of targeted or personalized therapies for what is currently an incurable and largely untreatable disorder.
Phase 1-2 Clinical Trial of a Recombinant AAV5 Vector Containing the Human FIX Gene in Patients with Severe or Moderately Severe Haemophilia B
Authors: Wolfgang A. Miesbach, Christian Meyer, Bart Nijmeijer, Florence Salmon, Nadina Grosios, Harald Petry, Frank W.G. Leebeek
Journal: Blood (2014)
OUTCOMES AND RISK FACTORS ASSOCIATED WITH GASTROINTESTINAL BLEEDING AMONG PATIENTS WITH SEVERE COVID-19
Authors: G.H.P. de Oliveira, D.T.H. de Moura, T.R McCarty, I.M. Proença, R.S.d.P. Rocha, A.S.T. Kum, C.F Moll, G.d.O. Luz, S. Cheng, M.E.L. dos Santos, E.G.H. de Moura
Journal: Endoscopy (2022)

Aims The coronavirus disease 2019 (COVID-19) caused by the novel coronavirus (SARS-CoV-2), most commonly associated with being a respiratory illness may manifest with multi-organ involvement, including the gastrointestinal (GI) system. Given the ongoing pandemic, there is an urgent need to understand the impact of GIB among a population of patients with COVID-19. Therefore, we sought to evaluate patients with severe COVID-19 and assess outcomes and risk factors associated with GIB.
ENDOSCOPIC RESECTION OF SUPERFICIAL ESOPHAGEAL NEOPLASIA IN THE CONTEXT OF CIRRHOSIS OR PORTAL HYPERTENSION: A MULTICENTER OBSERVATIONAL STUDY
Authors: M. Simonnot, J.B. Chevaux, M. Schaefer, E. Albuisson, C. Leal, P. Deprez, M. Pioche, T. Wallenhorst, F. Caillol, S. Koch, E. Coron, I. Archambeaud, J. Jacques, P. Basile, L. Caillo, T. Degand, V. Lepilliez, P. Grandval, A. Culetto, G. Vanbiervliet, O. Gronier, M. Camus Duboc, M. Barret
Journal: Endoscopy (2022)

Aims Cirrhotic patients are considered to be at high risk for esophageal cancer. Nowadays, endoscopic resection is the standard treatment for superficial tumors. Data are lacking about the management of portal hypertension in patients diagnosed with endoscopically resectable tumors. This study aims to assess safety, effectiveness and methods to prevent potential complications, especially bleeding in portal hypertension context.
The Central Cavitation in Pulmonary Diffuse Large B-Cell Lymphoma Detected by 18F-FDG PET/CT
Authors: Nan Lin, Hangyu Xie, Wenjie Zhang, Xuelei Ma
Journal: Clinical Nuclear Medicine (2022)

Primary pulmonary diffuse large B-cell lymphoma is a rare type of extranodal lymphoma with PET/CT manifestations of consolidations, ground-glass opacities, and high 18F-FDG uptake. Because of its rarity and the lack of typical imaging features, it can hardly be diagnosed through PET/CT. The central cavitation was occasionally seen in pulmonary diffuse large B-cell lymphoma and may be a key imaging feature in differential diagnoses. In this report, we describe an 80-year-old man diagnosed as having pulmonary diffuse large B-cell lymphoma, which demonstrated the central cavitation detected by 18F-FDG PET/CT.
THE COURSE OF PAIN AND DYSPHAGIA AFTER RADIOFREQUENCY ABLATION FOR BARRETT’S ESOPHAGUS RELATED NEOPLASIA
Authors: A. Overwater, E. Schoon, R.E. Pouw, J.J. Bergman, S.G. Elias, B.L. Weusten
Journal: Endoscopy (2022)

Aims Radiofrequency ablation(RFA) is an effective treatment for eradication of Barrett’s esophagus(BE) related neoplasia, but little is known on the course of pain and dysphagia after RFA. The aim of this study was to describe the course of post-RFA symptoms and to identify possible risk factors thereof.
12P Prevalence of functional and genomic homologous recombination deficiency (HRD) in germline RAD51C/D patients
Authors: A. Llop-Guevara, S. Torres-Esquius, M. Romey, S. Gutierrez-Enriquez, P.G. Nuciforo, O. Diez, G. Llort Pursals, A. Teule, A. Vallmajó, I. Diaz De Corcuera, I. Chirivella Gonzalez, S. Gonzalez Santiago, P. Sanchez Henarejos, J. Sanz Buxo, C. Guillen Ponce, A.B. Sanchez, J.M. Brunet Vidal, C. Denkert, V. Serra Elizalde, J. Balmaña
Journal: Annals of Oncology (2022)
COLONOSCOPY IN THE VERY ELDERLY: SHOULD WE JUST UTILISE THE CT SCANNER?
Authors: S. Williams, C. Bergbaum, B. Norton, A. Hung, S. Baskind, K. Besherdas
Journal: Endoscopy (2022)

Aims Lower gastrointestinal symptoms are common in the very elderly; however, colonoscopy is not always appropriate due to choice, fitness and/or periprocedural risk. In a cohort where the vast majority already undergo cross-sectional imaging, computed tomographic colonography (CTC) could become the first-line test. We analysed a very elderly cohort undergoing colonoscopy to assess the diagnostic yield and eventual treatment.
ENDOSCOPIC ULTRASOUND (EUS) AND ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY (ERCP) PERFORMED IN THE SAME SESSION DON’T INCREASE THE RISK OF SEDATION-RELATED COMPLICATIONS
Authors: S. Bota, M. Razpotnik, C. Urak, G. Essler, J. Weber-Eibel, M. Peck-Radosavljevic
Journal: Endoscopy (2022)

Aims To compare the risk of sedation-related complications of EUS and ERCP performed in the same vs. separate sessions
FEASIBILITY OF UNRESTRICTED DIET VERSUS A 3-DAY LOW-RESIDUE DIET PRE-COLONOSCOPY AND IT IMPACT ONTHE QUALITY OF THE BOWEL PREPARATION
Authors: S. Machlab, E. Martínez-Bauer, P. López, V. Puig-Diví, A. Lira, F. Junquera, P. Ruiz, M.d.M. Pujals, L. Hernández, A. Selva, B. García, B. López, J. Vives, E. Frisancho, F. Fernández-Bañares, X. Calvet, R. Campo
Journal: Endoscopy (2022)

Aims To compare the effect of unrestricted diet vesus a 3-day low-residue diet pre-colonoscopy in the quality of the bowel preparation
Whole-Genome Duplication Shapes the Aneuploidy Landscape of Human Cancers
Authors: Kavya Prasad, Mathew Bloomfield, Hagai Levi, Kristina Keuper, Sara V. Bernhard, Nicolaas C. Baudoin, Gil Leor, Yonatan Eliezer, Maybelline Giam, Cheng Kit Wong, Giulia Rancati, Zuzana Storchová, Daniela Cimini, Uri Ben-David
Journal: Cancer Research (2022)

Abstract Aneuploidy is a hallmark of cancer with tissue-specific prevalence patterns that suggest it plays a driving role in cancer initiation and progression. However, the contribution of aneuploidy to tumorigenesis depends on both cellular and genomic contexts. Whole-genome duplication (WGD) is a common macroevolutionary event that occurs in more than 30% of human tumors early in tumorigenesis. Although tumors that have undergone WGD are reported to be more permissive to aneuploidy, it remains unknown whether WGD also affects aneuploidy prevalence patterns. Here we analyzed clinical tumor samples from 5,586 WGD− tumors and 3,435 WGD+ tumors across 22 tumor types and found distinct patterns of aneuploidy in WGD− and WGD+ tumors. WGD+ tumors were characterized by more promiscuous aneuploidy patterns, in line with increased aneuploidy tolerance. Moreover, the genetic interactions between chromosome arms differed between WGD− and WGD+ tumors, giving rise to distinct cooccurrence and mutual exclusivity aneuploidy patterns. The proportion of whole-chromosome aneuploidy compared with arm-level aneuploidy was significantly higher in WGD+ tumors, indicating distinct dominant mechanisms for aneuploidy formation. Human cancer cell lines successfully reproduced these WGD/aneuploidy interactions, confirming the relevance of studying this phenomenon in culture. Finally, induction of WGD and assessment of aneuploidy in isogenic WGD−/WGD+ human colon cancer cell lines under standard or selective conditions validated key findings from the clinical tumor analysis, supporting a causal link between WGD and altered aneuploidy landscapes. We conclude that WGD shapes the aneuploidy landscape of human tumors and propose that this interaction contributes to tumor evolution. Significance: These findings suggest that the interactions between whole-genome duplication and aneuploidy are important for tumor evolution, highlighting the need to consider genome status in the analysis and modeling of cancer aneuploidy.
INTEGRATING PATIENT-ANALOGUE BILIARY ANATOMY FOR EXISTING HUMAN-BASED ARTIFICIAL ERCP TRAINING MODEL – ADVANTAGES OF 3D PRINTING TECHNOLOGY
Authors: U. Schweizer, B. Duckworth-Mothes, K. Koch, A. Königsrainer, D. Wichmann
Journal: Endoscopy (2022)

Aims ERCP (endoscopic retrograde cholangiopancreatography) is a challenging endoscopic procedure which requires profound anatomical and technical knowledge combined with optimal diagnostic and therapeutic experience as well as a good manual dexterity. Because ERCP is usually performed with therapeutic intent, training in this area remains a major challenge. The learning curve is often played out on the patient. Beyond that, the variety of different bile duct anomalies could not even be roughly reproduced in training models so far.
REAL-TIME ARTIFICIAL INTELLIGENCE (AI) AUTOMATIC DIAGNOSTIC SYSTEM FOR COLORECTAL POLYPS USING RESIDUAL NETWORK (RESNET)
Authors: Y. Komeda, H. Handa, S. Hatori, M. Takenaka, H. Kashida, M. Kudo
Journal: Endoscopy (2022)

Aims Convolutional neural networks (CNNs) are widely used for artificial intelligence (AI)-based image classification. Residual network (ResNet) is a new technology that facilitates the accuracy of image classification by CNN-based AI.
DETAILED MATERIAL ANALYSIS OF COMMONLY USED ENDOSCOPY INSTRUMENTS
Authors: P. López-Muñóz, R. Martín-Cabezuelo, V. Pons-Beltrán, G. Vilariño, P.A. Betín, I. Tort, A. Vidaurre, V. Lorenzo-Zúñiga
Journal: Endoscopy (2022)

Aims Gastrointestinal endoscopy requires considerable amount of single-use consumable instruments and supplies. Details on the material composition of these single use instruments are not publicly available.There is a need for providing details about materials involved to estimate the environmental impact of endoscopes or instruments. We aimed to analyze detailed composition of materials of three commonly used instruments: biopsy forceps, polypectomy snares and hemostatic clips.
COLONOSCOPY IN ELDERLY AND YOUNG SUBJECTS:WHAT INDICATIONS ARE ASSOCIATED WITH HIGH-RISK LESIONS FOR COLORECTAL NEOPLASIA?
Authors: A. Sair, A. Benhamdane, T. Addajou, M. Osman, S. Mrabti, R. Berraida, S. Sentissi, I. Elkoti, F. Rouilla, A. Benkirane, H. Seddik
Journal: Endoscopy (2022)

Aims The indications for colonoscopy are clearly defined, with an essential role in etiological diagnosis, including colorectal cancer screening. Common indications for young adults under 50years include rectorrhagia and diarrhea, whereas for subjects over50 years the indications may be broader given the risk of colorectal cancer.
ENDOSCOPIC RESECTION OF GASTRODUODENAL SUBEPITELIAL TUMORS: INITIAL EXPIRIENCE
Authors: M. Puig González, J. Colan-Hernandez, I. Marin, N. Caballero, I. Iborra, A. Calm, M. Fortuny, E. Garsot, A. Clavell, M. Viciano, E. Domenech, V. Moreno, H. Uchima
Journal: Endoscopy (2022)

Aims Describe the initial experience of our center in endoscopic resection of gastric and duodenum subepithelial lesions
ENDOSCOPIC SLEEVE GASTROPLASTY (ESG): SHORT-TERM EFFICACY AND SAFETY PROFILE IN A SINGLE CENTER SERIES
Authors: A.J. del Pozo-García, T. Valdés-Lacasa, D. Fresneda Cuesta, Á. Hidalgo, R. Polanco, S. Nevado, D. Rafael de la Cruz, F. Sánchez Gómez
Journal: Endoscopy (2022)

Aims ESG has positioned as one of the most promising incisionless techniques to induce gastric volume restriction leading to weight loss in patients with obesity, showing good results within a safe profile.
75P Interim analysis (n=150) of the multi-national, prospective, non-interventional ELEANOR study observing real-life extended adjuvant treatment with neratinib in patients with HER2+ / HR+ early breast cancer (eBC)
Authors: N. Harbeck, D. Wrobel, M. Zaiss, D. Guth, A. Distelrath, J. Terhaag, A. Lorenz, R. Bartsch, U. Breitenstein, M. Schwitter, M. Balic, C. Jackisch, V. Müller, G. Rinnerthaler, M. Schmidt, K. Zaman, T. Schinköthe, D. Lüftner
Journal: Annals of Oncology (2022)
159P Q-TWiST analysis of pembrolizumab combined with chemotherapy as first-line treatment of metastatic TNBC that expresses PD-L1
Authors: P.A. Fasching, M. Huang, A. Haiderali, W. Pan, P. Hu, M. Chaudhuri, C. Le Bailly De Tilleghem, N. Cappoen, J. O'Shaughnessy
Journal: Annals of Oncology (2022)
205TiP ATRACTIB: A phase II trial of first-line (1L) atezolizumab (A) in combination with paclitaxel (P) and bevacizumab (B) in metastatic triple-negative breast cancer (mTNBC)
Authors: A. Cortés Salgado, J.M. Perez Garcia, S.P. Cortez Castedo, M. Gion Cortes, S. Morales Murillo, I. Blancas López-Barajas, S. Blanch, I. Calvo Plaza, N. Diaz Fernandez, F. Marmé, A. Martinez Bueno, M.T. Taberner Bonastre, M. De Laurentiis, M. Ruiz Borrego, P. Schmid, V. Guarneri, J. Gligorov, M. Sampayo-Cordero, A. Llombart Cussac, J. Cortés
Journal: Annals of Oncology (2022)
STENT-IN-STENT BI-LOBAR BILIARY STENTING IN MALIGNANT HILAR OBSTRUCTION: EXPERIENCE AND OUTCOMES
Authors: S. Kotha, B. Natarajan, B. Warner, T. Wong, P. Berry
Journal: Endoscopy (2022)

Aims Endoscopic management of hilar malignant strictures is challenging with a high risk of complications. Traditionally, a percutaneous approach has been preferred but endoscopic bilobar drainage either by stent-in-stent or stent-by-stent placement of metal stents can be more beneficial to patients in experienced centres. We aimed to determine the clinical outcomes of bilobar stent-in-stent placement using large cell D-type (LCD, Taewoong Niti-S) stents in patients with malignant hilar strictures.
TATTOOING IN THE COLON – IS THE DESIGN INFLUENCED BY OUTCOME?
Authors: C.H. Khoo, H. McRobbie, R. Patel
Journal: Endoscopy (2022)

Aims Tattoo, using sterile carbon particle suspension, should be used to demarcate any lesion that may require localisation at future endoscopic or surgical procedures. There remains heterogeneity in the approach despite specific guidelines on lesion marking standards. We hypothesised that approach to tattooing is influenced by lesion management (endoscopic versus surgical).
DISEASE AND NON-DISEASE-RELATED RISK FACTORS FOR INADEQUATE BOWEL PREPARATION IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE: SHOULD THE STRATEGY BE DIFFERENT?
Authors: T. Lima Capela, V. Macedo Silva, M. Freitas, R. Sousa Magalhães, T. Cúrdia Gonçalves, F. Dias de Castro, M. João Moreira, J. Cotter
Journal: Endoscopy (2022)

Aims Colonoscopy is of utmost importance in the management of inflammatory bowel disease(IBD). Most studies on inadequate bowel preparation(IBP) have not specifically evaluated the impact of IBD on the quality of bowel preparation. We aimed to identify disease and non-disease related factors for IBP in patients with IBD submitted to colonoscopy.
The role of 11C-methionine PET in patients with newly diagnosed WHO grade 2 or 3 gliomas
Authors: Norbert Galldiks, Philipp Lohmann, Karl-Josef Langen
Journal: Neuro-Oncology (2022)

Journal Article The role of 11C-methionine PET in patients with newly diagnosed WHO grade 2 or 3 gliomas Get access Norbert Galldiks, Norbert Galldiks Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, GermanyInstitute of Neuroscience and Medicine (INM-3, -4), Research Center Juelich, Juelich, GermanyCenter of Integrated Oncology (CIO), Universities Aachen, Bonn, Cologne and Duesseldorf, Germany Corresponding Author: Norbert Galldiks, MD, Institute of Neuroscience and Medicine (INM-3), Research Center Juelich, Leo-Brandt-St. 5, Juelich 52425, Germany (n.galldiks@fz-juelich.de); Department of Neurology, University Hospital Cologne, Kerpener St. 62, Cologne 50937, Germany (norbert.galldiks@uk-koeln.de). https://orcid.org/0000-0002-2485-1796 Search for other works by this author on: Oxford Academic PubMed Google Scholar Philipp Lohmann, Philipp Lohmann Department of Stereotaxy and Functional Neurosurgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany https://orcid.org/0000-0002-5360-046X Search for other works by this author on: Oxford Academic PubMed Google Scholar Karl-Josef Langen Karl-Josef Langen Institute of Neuroscience and Medicine (INM-3, -4), Research Center Juelich, Juelich, GermanyCenter of Integrated Oncology (CIO), Universities Aachen, Bonn, Cologne and Duesseldorf, GermanyDepartment of Nuclear Medicine, RWTH Aachen University Hospital, Aachen, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Neuro-Oncology, Volume 24, Issue 9, September 2022, Pages 1557–1558, https://doi.org/10.1093/neuonc/noac120 Published: 06 May 2022 Article history Published: 06 May 2022 Corrected and typeset: 27 May 2022
EUS-GUIDED MANAGEMENT OF POST-SURGICAL INJURY USING LAMS IN PATIENTS WITH BILIARY TRACT STRICTURES
Authors: C. Robles-Medranda, M. Arevalo-Mora, M. Puga-Tejada, J. Alcivar-Vasquez, R. Del Valle
Journal: Endoscopy (2022)

Lumen-apposing metal stents (LAMS) are a newly available therapeutic alternative for therapy in post-surgical biliary tract strictures. Two young adult females presented with post-surgical biliary tract stricture injury. Only the first case required intraoperative hepaticojejunostomy. Both developed a cholestatic pattern. We performed an EUS-guided antegrade drainage using LAMS with no reported periprocedural complications. The total and direct bilirubin levels had exponentially decreased. Currently, the patients remain stable. When feasible, EUS-guided management of post-surgical injury using LAMS may be a novel, safe, and effective alternative for patients with iatrogenic biliary tract strictures.