tbuckley/cabot-search huggingface dataset:
Does stress cause cancer?
Authors: R. McGee
Journal: BMJ (1999)

Papers p 1027 

In 1893 Snow presented what might be the first statistical summary of the psychological characteristics of patients with breast or uterine cancer.1 Some 250 women with these cancers were described as having a “general liability to the buffets of ill-fortune.” Over 100 years later we still find researchers preoccupied with showing whether stressful life events are related to cancer—as in this week's study by Protheroe et al (p 1027)2. Many clearly believe that life is more stressful than ever before and that one consequence of this ubiquitous stress is disease, including cancer. Sontag describes this as a metaphorical view of disease as the “outward expression of character.”3 In more practical terms, patients with cancer may believe that their disease results from too much stress and relatives may feel guilty for contributing to the emotional ill health of the patient. Such beliefs may also have a bearing on what people do about seeking and sticking to treatment. It is important therefore to have a clear idea of what the evidence does show.

Two recent literature reviews have concluded that there is no good evidence for any relation between stressful life events and breast cancer,4 5 and both point out that the typical …
Compliance with boil water advice following a water contamination incident in the Netherlands in 2007
Authors: I Karagiannis, B Schimmer, A  M de Roda Husman
Journal: Eurosurveillance (2009)

In May 2007, Escherichia coli was detected in tap water supplied by a company in North Holland. The company issued advice through mass media to boil tap water before consumption; this advice was lifted six days later. A cross-sectional study was implemented to investigate compliance among residents in this area. Based on postcode, a total of 300 households, chosen randomly from a database of a private company performing internet-based surveys for different marketing purposes, were sent a self-administered questionnaire for this study. The questionnaire contained questions on demographic information, source of information regarding the advice, response to it and personal opinions on the company's reaction and the advice. Ninety-nine (66%) households of the affected area and 90 (60%) households from non-affected areas served by the same company replied to the survey. All respondents knew about the advice. 81.8% of the respondents in the affected area and 5.6% of the non-affected areas reported complying with the advisory. Most respondents from the affected area still used unboiled water to brush teeth, wash salads and wash fruit. There was no difference in compliance between men and women. Using the mass media was proved to be efficient to inform the public and could be used in the future in similar settings. However, more detailed wording of boiling advice should be considered in the future.
Management Choices for Hypertension with Coexistent Hypercholesterolaemia
Authors: M D Feher, A F Lant
Journal: Journal of the Royal Society of Medicine (1991)

Guidelines for the management of either hypertension or hyperlipidaemia have been widely published. However, recent data have shown the high frequency of an abnormal lipid profile in hypertensive subjects. We have therefore surveyed 195 general practitioners throughout Britain to determine current community-based attitudes and management approaches to hypertension with coexistent hypercholesterolaemia. Routine screening for lipids in hypertensive subjects was recommended by 40% of respondents. First-line antihypertensive drug choices were influenced by the knowledge of a hypercholesterolaemia, with preference for drugs known to have no adverse effects on the lipid profile. When first-choice drug failed to effectively lower blood pressure, the additional drug or the substitute choices were not influenced by the metabolic profiles of the alternative selected. The current wide choice of antihypertensive drugs and the complexity of metabolic complications of treatment plus the relationship of risk factor clustering has made the formulation of management strategies very difficult. This was supported by the finding that 88% of respondents in our survey felt that there was a clear need for consensus management guidelines for the treatment of hypertension with coexistent hypercholesterolaemia.
Abstract 15941: A Strategy of Optimized Medical Management and Selective “Downstream” Procedures Following Cardiac CT Results in Extremely Low Cardiac Event Rate and All-Cause Mortality
Authors: Seth Uretsky, Alan Rozanski, Edward A Fisher, Ron Sklash, Azhar Supariwala, Sonal Kamalia, Kiran Reddy, Narasa Challa, Niriksha Sathyanarayana, Gargi Thotakura, M R Peters, Steven D Wolff
Journal: Circulation (2010)

Background: Prior studies have consistently demonstrated increased mortality in patients that have elevated coronary artery calcium (CAC) scores or those that have more severe stenoses on coronary ...
Small Molecule Inhibitors of USP1 Target ID1 Degradation in Leukemic Cells and Cause Cytotoxicity
Authors: Helena Mistry, Grace Hsieh, Sara Buhrlage, Min Huang, Eunmi Park, Gregory Cuny, Ilene Galinsky, Richard M. Stone, Nathanael S Gray, Kalindi Parmar, Alan D. D'Andrea
Journal: Blood (2013)
Abstract 4212: Does Intravascular Ultrasound Guidance for Patients Undergoing Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction Impact Outcome?
Authors: Gabriel Maluenda, Gilles Lemesle, Itsik Ben-Dor, Sara D Collins, Asmir Syed, Yanlin Li, Cedric Delhaye, Kohei Wakabayashi, Rebecca Torguson, Kimberly Kaneshige, Zehnyi Xue, Rajbabu Pakala, Mickey Scheinowitz, William O Suddath, Lowell F Satler, Kenneth M Kent, Joseph M Lindsay, Augusto D Pichard, Ron Waksman
Journal: Circulation (2009)
Syndecan-1 Is a Multifunctional Regulator of Myeloma Pathobiology: Control of Tumor Cell Survival, Growth, and Bone Cell Differentiation
Authors: Madhav V. Dhodapkar, Etsuko Abe, Allison Theus, Marie Lacy, J. Kevin Langford, Bart Barlogie, Ralph D. Sanderson
Journal: Blood (1998)
Autologous transplantation of ex vivo expanded bone marrow cells grown from small aliquots after high-dose chemotherapy for breast cancer
Authors: Patrick Stiff, Bohao Chen, Wilbur Franklin, David Oldenberg, Eric Hsi, Robert Bayer, Elizabeth Shpall, Judy Douville, Ramkumar Mandalam, Deepak Malhotra, Thomas Muller, R. Douglas Armstrong, Alan Smith
Journal: Blood (2000)
Abstract 11164: Dialysis-Related Symptoms are Associated with Deterioration of Cardiac Function During Dialysis
Authors: Ruth Dubin, Nelson B Schiller, John R Teerlink, Dean Alokozai, Kirsten Johansen
Journal: Circulation (2011)

Background: Individuals with end-stage renal disease on dialysis have an increased risk of cardiovascular death. The immediate effects of hemodialysis on cardiac function are poorly understood. We hypothesized that hemodialysis may have a detrimental effect on cardiac function and that symptoms during and after dialysis correlate with deterioration of cardiac function during dialysis. Methods: Forty patients underwent echocardiography directly before and during the last hour of dialysis. We measured change in diastolic function, ejection fraction and wall motion score. Intradialytic symptoms such as cramping and fatigue lasting more than 2 hours after dialysis were evaluated by questionnaire. Echocardiograms were read by a single blinded reader at a reading center. Results: During dialysis, diastolic function worsened in 32% and improved in 12% (two-sided p=0.03 for difference between proportions). Ejection fraction did not change (mean±SD: 0±4%). Wall motion score worsened in 23% and improved in 5% (p=0....
Tuberculosis in England and Wales
Authors: M. Catchpole
Journal: BMJ (1995)

Incidence of tuberculosis in London is rising against general recent trend

EDITOR,--The papers by N Bhatti and colleagues1 and Punam Mangtani and colleagues,2 are an important reminder of the relation between health and deprivation. Both papers highlight the increase in reported notifications of all forms of tuberculosis in England and Wales between 1986 and 1992. This increase continued into 1993, but the number of reported notifications of all forms of tuberculosis fell between 1993 and 1994.

I …
Abstract 14049: Improving the Cardiovascular Health of Underserved Populations With Life's Simple 7
Authors: Marcia Murphy, Lola A Coke, Beth A Staffileno, Janis D Robinson, Robin J Tillotson
Journal: Circulation (2013)

Background: Cardiovascular disease (CVD) is the leading cause of death and disability in the U.S with disproportionate burden on racial/ethnic and underserved populations. Purpose: To improve the c...
Genitourinary medicine should remain a separate specialty
Authors: J S Bingham
Journal: BMJ (1996)

Acute respiratory illness (ARill) is common and threatens the health of athletes. ARill in athletes forms a significant component of the work of Sport and Exercise Medicine (SEM) clinicians. The aim of this consensus is to provide the SEM clinician with an overview and practical clinical approach to non-infective ARill in athletes. The International Olympic Committee (IOC) Medical and Scientific Committee appointed an international consensus group to review ARill in athletes. Key areas of ARill in athletes were originally identified and six subgroups of the IOC Consensus group established to review the following aspects: (1) epidemiology/risk factors for ARill, (2) infective ARill, (3) non-infective ARill, (4) acute asthma/exercise-induced bronchoconstriction and related conditions, (5) effects of ARill on exercise/sports performance, medical complications/return-to-sport (RTS) and (6) acute nasal/laryngeal obstruction presenting as ARill. Following several reviews conducted by subgroups, the sections of the consensus documents were allocated to ‘core’ members for drafting and internal review. An advanced draft of the consensus document was discussed during a meeting of the main consensus core group, and final edits were completed prior to submission of the manuscript. This document (part 2) of this consensus focuses on respiratory conditions causing non-infective ARill in athletes. These include non-inflammatory obstructive nasal, laryngeal, tracheal or bronchial conditions or non-infective inflammatory conditions of the respiratory epithelium that affect the upper and/or lower airways, frequently as a continuum. The following aspects of more common as well as lesser-known non-infective ARill in athletes are reviewed: epidemiology, risk factors, pathology/pathophysiology, clinical presentation and diagnosis, management, prevention, medical considerations and risks of illness during exercise, effects of illness on exercise/sports performance and RTS guidelines.
ソラフェニブ抵抗性肝細胞癌患者(HCC)におけるHDAC阻害剤レスミノスタットの第I相/II相の臨床最新結果‐シェルター試験
Authors: Bitzer Michael, Horger Markus, Ganten Tom, P Ebert Matthias, T Siveke Jens, A Woerns Marcus, M Dollinger Matthias, Gerken Guido, E Scheulen Max, Mais Anna, Jankowsky Ruediger, Hauns Bernhard, Hentsch Bernd, M Lauer Ulrich
Journal: Annals of Oncology (2011)
Types of resistance to imatinib and other potential predictors of response to second-line dasatinib therapy.
Authors: G. Saglio, J. E. Cortes, C. A. Schiffer, P. le Coutre, E. Jabbour, E. Bahceci, A. Lambert, N. P. Shah
Journal: Journal of Clinical Oncology (2010)

6569 Background: Management of chronic myeloid leukemia (CML) has evolved from nonspecific conventional chemotherapy with hydroxyurea or busulfan, with poor efficacy, to therapy with interferon-α alone or with cytarabine in patients ineligible for transplantation. BCR- ABL-targeted tyrosine kinase inhibitors like imatinib have changed the landscape of CML treatment and produced improved rates of long-term response and survival. However, resistance to imatinib has emerged as a significant clinical issue. Treatment with second-line dasatinib can overcome multiple mechanisms of resistance to imatinib in patients with chronic-phase CML. This study compares the response and outcome in patients primarily refractory to imatinib with those who responded to imatinib but relapsed, as well as the effect of other prior treatments. Methods: Two-year follow-up data from all dose and schedule arms of the CA180-034 study were analyzed. Results: Based on univariate analyses, patients receiving dasatinib 100mg once daily who were pretreated with interferon-α had a lower likelihood of achieving complete cytogenetic response (CCyR; 39% vs. 61%). Similarly, the CCyR rate was lower among patients who had undergone prior transplantation (38% vs. 50%) in the 100 mg once daily arm. The 24-month rates of progression-free survival (73% vs. 71%) and overall survival (89% vs. 89%) were similar between patients with primary or secondary resistance to imatinib in those receiving any dose of dasatinib. Patients with prior CCyR or those < 18 months from diagnosis of CML exhibited more durable major cytogenetic response. Conclusions: These data suggest that patients who are minimally pretreated have a greater likelihood of achieving CCyR on dasatinib. The type of resistance to imatinib may impact the likelihood of response to second-line dasatinib; patients who had once benefited from imatinib appear to have improved response rates with dasatinib compared with patients with primary resistance. With relatively limited follow- up, both groups experienced similar survival outcomes. Further analysis evaluating the type and degree of imatinib resistance is ongoing to assess the impact on outcomes with second-line dasatinib. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Bristol-Myers Squibb Bristol-Myers Squibb, Chemgenix, Merck, Novartis, Wyeth Novartis Bristol-Myers Squibb, Merck, Novartis Bristol-Myers Squibb, Novartis
Successful in vivo purging of CD34-containing peripheral blood harvests in mantle cell and indolent lymphoma: evidence for a role of both chemotherapy and rituximab infusion
Authors: Michele Magni, Massimo Di Nicola, Liliana Devizzi, Paola Matteucci, Fabrizio Lombardi, Lorenza Gandola, Fernando Ravagnani, Roberto Giardini, Giuseppe Dastoli, Corrado Tarella, Alessandro Pileri, Gianni Bonadonna, Alessandro M. Gianni
Journal: Blood (2000)
Caring for and about acute general medicine
Authors: K G M M Alberti, J D Ward, K. Schiller, I. S Shaw, J. A Chambers, N. Cooper
Journal: BMJ (1999)

Editor—Forgacs’s review provides an excellent picture of the unpleasant reality of acute medicine, as practised at present.1 The Royal College of Physicians is well aware of the need to cost future improvements in increasing the number of hospital doctors and to provide evidence of the likely benefits. The latter will be a difficult task but must be tackled. Indeed, a working group of the three Royal Colleges of Physicians is currently reviewing all aspects of the problems regarding acute medicine.

As chairman of the group which produced the document “Consultant physicians working for patients” and main author,2 I (JDW) can assure readers that I have had experience, on many occasions, of handling more than 20 acutely ill patients during a 24 hour period of acute medicine as a general physician in Sheffield. Our working group realises that hundreds more consultants tomorrow and much smaller numbers of “take patients” is unrealistic. We do know from several sources that doctors are working 14-16 sessions per week and close to a 60 hour week. We know that consultation times in outpatient departments have been pared to the bone. We know that clinical governance in all its guises will place further demands on consultants. If we do not state our requirements now for an expansion in the number of consultants we will never achieve improvements.
Factors associated with suicide attempts by depressed older adults: a prospective study
Authors: R A Zweig, G A Hinrichsen
Journal: American Journal of Psychiatry (1993)

This study sought to ascertain demographic, clinical, and interpersonal factors prospectively associated with suicide attempts by older adults with major depressive disorder.Elderly inpatients diagnosed as having major depressive disorder according to the Research Diagnostic Criteria were administered a structured diagnostic interview and then followed up for 1 year. Factors bearing on the interpersonal context of depression, including the emotional adjustment of patients' spouses and adult children, interpersonal strains, and relatives' concerns related to the care of their depressed family members, were also ascertained at the time of the patients' hospital admission. The elderly patients who attempted suicide during the follow-up period were compared with the nonattempters across demographic, clinical, and interpersonal factors assessed during the initial interviews.A suicide attempt was made by 8.7% (N = 11) of the 126 elderly depressed patients within 1 year after hospital admission. Compared with the nonattempters, the attempters were of a higher socioeconomic status, evidenced more past suicide attempts and current suicidal behavior, and constituted a disproportionately large percentage of those patients who had never had a remission of their index depressive episodes. Notably, the spouses and adult children of patients who later attempted suicide evidenced more psychiatric symptoms, more strain in the relative-patient relationship, and more difficulties in caring for the patient than the relatives of nonattempters.The findings emphasize the need for careful attention to both clinical and interpersonal factors in the assessment of suicide risk in the elderly.
Abstract 2361: Bone Marrow Dysfunction In Chronic Heart Failure Patients Contributes To Impaired Erythropoiesis
Authors: B.D. Westenbrink, Adriaan A Voors, Annet Vos, Pim van der Harst, Edo Vellenga, Rudolf A. de Boer, Dirk J van Veldhuisen, Wiek H van Gilst
Journal: Circulation (2008)

Background: We hypothesised that anemia in chronic heart failure (CHF) patients is caused by bone marrow dysfunction. Methods: Bone marrow was harvested during cardiac surgery from 17 patients with CHF (LVEF 32 ± 1.8 %) and 17 age matched control patients with normal cardiac function (LVEF ≥ 55%). Early hematopoietic progenitor cells (CD34 + ) and committed erythroid cells (CD71 bright ), apoptosis (Annexin-V + /DAPI + ) and EPO-receptor (EPO-R) density were quantified by FACS. Erythroid and myeloid colony formation of isolated CD34 + cells was assessed in methylcellulose containing incrementing doses of erythropoietin (EPO) or myeloid cytokines. After 14 days Burst Forming Units Erythroid (BFU-E) or granulocyte and monocyte colonies were quantified. Results: Patients with CHF had lower hemoglobin levels and 35% of CHF patients had anemia. The numbers of CD34 + and CD71 bright cells were 2 fold lower in CHF patients (P &lt; 0.05). Throughout the EPO dose-response range, CD34+ cells of CHF patients produced a 3-fold lower number of BFU-E colonies than controls (figure 1 , P &lt; 0.02). Concomittantly, myeloid colony formation was 2 fold lower in CHF patients as well (P &lt; 0.05). This was associated with markedly increased apoptosis (P &lt; 0.01), but equivalent EPO-receptor expression. Lower BFU-E numbers were independently associated with higher NTproBNP levels (R = − 0.5, P = 0.03). However, BFU-E formation was comparable in anemic and non-anemic CHF patients (P = 0.8). Conclusions : General bone marrow dysfunction in CHF patients contributes to impaired erythropoiesis. Although this might render patients more susceptible to anemia, it does not exclusively explain its occurrence. Impaired erythropoiesis in heart failure patients
Right Intraventricular Dyssynchrony in Idiopathic, Heritable, and Anorexigen-Induced Pulmonary Arterial Hypertension
Authors: Roberto Badagliacca, Manuela Reali, Roberto Poscia, Beatrice Pezzuto, Silvia Papa, Mario Mezzapesa, Martina Nocioni, Gabriele Valli, Elisa Giannetta, Susanna Sciomer, Carlo Iacoboni, Francesco Fedele, Carmine Dario Vizza
Journal: JACC. Cardiovascular imaging (2015)

The aim of this study was to determine the prevalence of right intraventricular dyssynchrony, its determinants and prognostic impact in idiopathic, heritable, and anorexigen-induced pulmonary arterial hypertension.Right ventricular dyssynchrony has been described in pulmonary arterial hypertension, but no evidence is available on its prognostic impact and evolution after therapy.In 83 consecutive therapy-naïve patients, right ventricular dyssynchrony was evaluated by 2-dimensional speckle-tracking echocardiography calculating the standard deviation of the times to peak-systolic strain for the 4 mid-basal right ventricular segments (RV-SD4). After baseline (World Health Organization [WHO] class, pulmonary hemodynamics, 6-min walk test [6 MWT]), a second assessment was performed after 12 months or when clinical worsening occurred.Patients with right ventricular dyssynchrony (RV-SD4 >18 ms) had advanced WHO class, worse 6 MWT, right ventricular remodeling, and hemodynamic profile compared with patients ≤ 18 ms. Determinants of dyssynchrony included pulmonary vascular resistance, QRS duration, and right ventricular end-diastolic area (r(2) = 0.38; p < 0.000001). At 12 months, 32.5% of patients presented clinical worsening (actuarial rates: 19% at 6 months, 31% at 1 year). Multivariable models for clinical worsening prediction showed that the addition of RV-SD4 to clinical and hemodynamic variables (WHO IV, 6 MWT, and cardiac index) significantly increased the prognostic power of the model (0.74 vs. 0.81; p = 0.005, 95% confidence interval [CI]: 0.02 to 0.11). Receiver operating characteristic analysis identified RV-SD4 ≥ 23 ms as the best cutoff value for clinical worsening prediction (95% negative predictive value). At 12 months, normalization of dyssynchrony was achieved in patients with a large reduction of pulmonary vascular resistance (-42 ± 4%).Right ventricular dyssynchrony is frequent in pulmonary arterial hypertension, is an independent predictor of clinical worsening, and might regress during effective treatments.
Abstract 16631: Long Term in vivo Stem Cell Tracking Using Contrast Ultrasound
Authors: Huili Fu, Jianjun Wang, Xucai Chen, Xiaoping Leng, Stephen Thorne, Flordeliza Villanueva
Journal: Circulation (2011)

Background: Human mesenchymal stem cell (hMSC) therapy is promising for cardiac repair. Clinical translation requires a method to serially track cell distribution in vivo. We have previously shown that polylactide microbubbles (MB) are internalized by hMSC, persist in the cytoplasm, and allow ultrasound (US) imaging of intramuscularly injected stem cells in mice, but only up to 4 hr at 37°C. We sought to design a more durable MB for prolonged US cell tracking and validated our method against in vivo bioluminescence imaging (BLI). Methods: Nitrogen gas polymer MB with a polycaprolactone and albumin double layer shell were synthesized. MB acoustic activity was measured in a water tank (Contrast Pulse Sequencing, 7MHz) after synthesis (Day 0) and 7 day storage at 37°C. Cultured hMSC expressing luciferase gene were incubated with MB. MB uptake was studied by confocal microscopy. MB-hMSC complexes or control hMSC were lifted, washed, and re-suspended for in vitro US imaging or in vivoinjection (INJ) (0.5-1.0 x...
Detailed studies on expression and function of CD19 surface determinant by using B43 monoclonal antibody and the clinical potential of anti- CD19 immunotoxins
Authors: FM Uckun, W Jaszcz, JL Ambrus, AS Fauci, K Gajl-Peczalska, CW Song, MR Wick, DE Myers, K Waddick, JA Ledbetter
Journal: Blood (1988)
Increased Local Disorder of DNA Methylation Forms the Basis of High Intra-Leukemic Epigenetic Heterogeneity and Enhances CLL Evolution
Authors: Dan-Avi Landau, Kendell Clement, Patrick Boyle, Michael Ziller, Kristen E. Stevenson, Dylan Kotliar, Gordon Saksena, M. Eng, Carrie Sougnez, Wandi Zhang, Mahmoud Ghandi, Levi Garraway, Stacey Gabriel, Eric S. Lander, Jennifer R. Brown, Donna S. Neuberg, Nir Hacohen, Gad Getz, Alexander Meissner, Catherine J. Wu
Journal: Blood (2013)