Effects of Low-Carbohydrate and Low-Fat Diets
Authors: Alberto Donzelli, Alessandra Lafranconi
Journal: Annals of Internal Medicine (2015)

Letters3 March 2015Effects of Low-Carbohydrate and Low-Fat DietsAlberto Donzelli, MD and Alessandra Lafranconi, MD, MScAlberto Donzelli, MDFrom Azienda Sanitaria Locale di Milano, Milan, Italy, and Università di Milano-Bicocca, Milan, Italy.Search for more papers by this author and Alessandra Lafranconi, MD, MScFrom Azienda Sanitaria Locale di Milano, Milan, Italy, and Università di Milano-Bicocca, Milan, Italy.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-5057-2 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In Bazzano and colleagues' trial of 148 obese patients carried out in a single medical center (1), a low-carbohydrate (<40 g/d) diet was associated with greater reductions in weight, fat mass, total–high-density lipoprotein cholesterol ratio, and triglyceride levels than a low-fat (<30% of daily energy intake from total fat) diet at 12-month follow-up. The authors concluded, “The low-carbohydrate diet was more effective for weight loss and cardiovascular risk factor reduction than the low-fat diet. Restricting carbohydrate may be an option for persons seeking to lose weight and reduce cardiovascular risk factors.” This conclusion concurs with the results ...References1. Bazzano LA, Hu T, Reynolds K, Yao L, Bunol C, Liu Y, et al. Effects of low-carbohydrate and low-fat diets: a randomized trial. Ann Intern Med. 2014;161:309-18. [PMID: 25178568]. doi:10.7326/M14-0180 LinkGoogle Scholar2. Johnston BC, Kanters S, Bandayrel K, Wu P, Naji F, Siemieniuk RA, et al. Comparison of weight loss among named diet programs in overweight and obese adults: a meta-analysis. JAMA. 2014;312:923-33. [PMID: 25182101] doi:10.1001/jama.2014.10397 CrossrefMedlineGoogle Scholar3. Schwarzfuchs D, Golan R, Shai I. Four-year follow-up after two-year dietary interventions [Letter]. N Engl J Med. 2012;367:1373-4. [PMID: 23034044] doi:10.1056/NEJMc1204792 CrossrefMedlineGoogle Scholar4. Vergnaud AC, Norat T, Mouw T, Romaguera D, May AM, Bueno-de-Mesquita HB, et al. Macronutrient composition of the diet and prospective weight change in participants of the EPIC-PANACEA study. PLoS One. 2013;8:e57300. [PMID: 23472080] CrossrefMedlineGoogle Scholar5. Fung TT, van Dam RM, Hankinson SE, Stampfer M, Willett WC, Hu FB. Low-carbohydrate diets and all-cause and cause-specific mortality: two cohort studies. Ann Intern Med. 2010;153:289-98. [PMID: 20820038]. doi:10.7326/0003-4819-153-5-201009070-00003 LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Azienda Sanitaria Locale di Milano, Milan, Italy, and Università di Milano-Bicocca, Milan, Italy.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOf InterestForms.do?msNum=L14-0509. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffects of Low-Carbohydrate and Low-Fat Diets Lydia A. Bazzano , Tian Hu , Kristi Reynolds , Lu Yao , Calynn Bunol , Yanxi Liu , Chung-Shiuan Chen , Michael J. Klag , Paul K. Whelton , and Jiang He Effects of Low-Carbohydrate and Low-Fat Diets Lydia A. Bazzano , Tian Hu , Kristi Reynolds , Lu Yao , Calynn Bunol , Yanxi Liu , Chung-Shiuan Chen , Michael J. Klag , Paul K. Whelton , and Jiang He Effects of Low-Carbohydrate and Low-Fat Diets Stephen F. Burns and Masashi Miyashita Effects of Low-Carbohydrate and Low-Fat Diets Gaetano Santulli Effects of Low-Carbohydrate and Low-Fat Diets Murray Skeaff , Jim Mann , Lisa Te Morenga , and Rachael McLean Effects of Low-Carbohydrate and Low-Fat Diets Lydia A. Bazzano and Tian Hu Effects of Low-Carbohydrate and Low-Fat Diets Stephen F. Burns and Masashi Miyashita Effects of Low-Carbohydrate and Low-Fat Diets Lydia A. Bazzano and Tian Hu Effects of Low-Carbohydrate and Low-Fat Diets Murray Skeaff , Jim Mann , Lisa Te Morenga , and Rachael McLean Effects of Low-Carbohydrate and Low-Fat Diets Gaetano Santulli Metrics 3 March 2015Volume 162, Issue 5Page: 391-392KeywordsCholesterolConflicts of interestDietDisclosureFatsLipoproteinsMedical risk factorsOverweightWeight loss ePublished: 3 March 2015 Issue Published: 3 March 2015 CopyrightCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...