tbuckley/cabot-search huggingface dataset:
Noninvasive Dual-Modality Photoacoustic-Ultrasonic Imaging to Detect Mammalian Embryo Abnormalities after Prenatal Exposure to Methylmercury Chloride (MMC): A Mouse Study
Authors: Qi Qiu, Yali Huang, Bei Zhang, Doudou Huang, Xin Chen, Zhongxiong Fan, Jinpei Lin, Wensheng Yang, Kai Wang, Ning Qu, Juan Li, Zhihong Li, Jingyu Huang, Shenrui Li, Jiaxing Zhang, Gang Liu, Gang Rui, Xiaoyuan Chen, Qingliang Zhao
Journal: Environmental Health Perspectives (2022)

Severe environmental pollution and contaminants left in the environment due to the abuse of chemicals, such as methylmercury, are associated with an increasing number of embryonic disorders. Ultrasound imaging has been widely used to investigate embryonic development malformation and dysorganoplasia in both research and clinics. However, this technique is limited by its low contrast and lacking functional parameters such as the ability to measure blood oxygen saturation (SaO2) and hemoglobin content (HbT) in tissues, measures that could be early vital indicators for embryonic development abnormality. Herein, we proposed combining two highly complementary techniques into a photoacoustic-ultrasound (PA-US) dual-modality imaging approach to noninvasively detect early mouse embryo abnormalities caused by methylmercury chloride (MMC) in real time.This study aimed to assess the use of PA-US dual-modality imaging for noninvasive detection of embryonic toxicity at different stages of growth following prenatal MMC exposure. Additionally, we compared the PA-US imagining results to traditional histological methods to determine whether this noninvasive method could detect early developmental defects in utero.Different dosages of MMC were administrated to pregnant mice by gavage to establish models of different levels of embryonic malformation. Ultrasound, photoacoustic signal intensity (PSI), blood oxygen saturation (SaO2), and hemoglobin content (HbT) were quantified in all experimental groups. Furthermore, the embryos were sectioned and examined for pathological changes.Using PA-US imaging, we detected differences in PSI, SaO2, HbT, and heart volume at embryonic day (E)14.5 and E11.5 for low and high dosages of MMC, respectively. More important, our results showed that differences between control and treated embryos identified by in utero PA-US imaging were consistent with those identified in ex vivo embryos using histological methods.Our results suggest that noninvasive dual-modality PA-US is a promising strategy for detecting developmental toxicology in the uterus. Overall, this study presents a new approach for detecting embryonic toxicities, which could be crucial in clinics when diagnosing aberrant embryonic development. https://doi.org/10.1289/EHP8907.
Journal Amer Geriatrics Society, Baltimore
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Internalizing behavior problems in early life are associated with the risk of childhood asthma: The COCOA study
Authors: Jisun Yoon, Ji Seon Kim, Dong In Suh, So-Yeon Lee, Youn Ho Shin, Kyung Won Kim, Kangmo Ahn, Yee-Jin Shin, Kyung-Sook Lee, Min Jee Park, Kun Baek Song, Eom Ji Choi, Hyun-Ju Cho, Sungsu Jung, Soo-Jong Hong
Journal: Journal of Allergy and Clinical Immunology (2022)
European Society of Cardiology quality indicators for the care and outcomes of adults with heart failure. Developed by the Working Group for Heart Failure Quality Indicators in collaboration with the Heart Failure Association of the European Society of Cardiology
Authors: Suleman Aktaa, Marija Polovina, Giuseppe Rosano, Amr Abdin, Manuel Anguita, Mitja Lainscak, Lars H. Lund, Theresa McDonagh, Marco Metra, Richard Mindham, Massimo Piepoli, Stefan Störk, Mariya P. Tokmakova, Petar Seferović, Chris P. Gale, Andrew J.S. Coats
Journal: European Journal of Heart Failure (2022)
Criteria for Iron Deficiency in Patients With Heart Failure
Authors: Gabriele Masini, Fraser J. Graham, Pierpaolo Pellicori, John G.F. Cleland, Joseph J. Cuthbert, Syed Kazmi, Riccardo M. Inciardi, Andrew L. Clark
Journal: Journal of the American College of Cardiology (2022)

Guidelines on heart failure (HF) define iron deficiency (ID) as a serum ferritin <100 ng/mL or, when 100-299 ng/mL, a transferrin saturation (TSAT) <20%. Inflammation (common in HF) may hinder interpretation of serum ferritin. This study sought to investigate how different definitions of ID affect its prevalence and relationship to prognosis in ambulatory patients with chronic HF. Prevalence, relationship with patients’ characteristics, and outcomes of various ID definitions were evaluated among patients with HF referred to a regional clinic (Hull LifeLab) from 2001 to 2019. Of 4,422 patients with HF (median age 75 years [range: 68-82 years], 60% men, 32% with reduced left ventricular ejection fraction), 46% had TSAT <20%, 48% had serum iron ≤13 μmol/L, 57% had serum ferritin <100 ng/mL, and 68% fulfilled current guideline criteria for ID, of whom 35% had a TSAT >20%. Irrespective of definition, ID was more common in women and those with more severe symptoms, anemia, or preserved ejection fraction. TSAT <20% and serum iron ≤13 μmol/L, but not guideline criteria, were associated with higher 5-year mortality (HR: 1.27; 95% CI: 1.14-1.43; P < 0.001; and HR: 1.37; 95% CI: 1.22-1.54; P < 0.001, respectively). Serum ferritin <100 ng/mL tended to be associated with lower mortality (HR: 0.91; 95% CI: 0.81-1.01; P = 0.09). Different definitions of ID provide discordant results for prevalence and prognosis. Definitions lacking specificity may attenuate the benefits of intravenous iron observed in trials while definitions lacking sensitivity may exclude patients who should receive intravenous iron. Prespecified subgroup analyses of ongoing randomized trials should address this issue.
Inhibition of protein synthesis in liver stellate cells (LSC) by an antisense oligonucleotide derived from an RNA-binding protein of activated LSC 1First Dept. of Internal Medicine, Faculty of Med. University of Tokyo, Tokyo, Japan; 2Third Dept. of Internal Medicine, Saitama Med. School, Saitama, Japan; 3Brookdale Ctr. for Mol. Biol., Mt Sinai School of Med., New York, N.Y. and 4Marion Bessin Liver Res. Ctr. and Depts of Medicine and Pathology, Albert Einstein Coll of Med. Bronx, N.Y.
Journal: Hepatology (1995)
Efficacy of Tezepelumab in Patients with Moderate-to-Severe, Uncontrolled Asthma: A Pooled Analysis of the Phase 2b PATHWAY and Phase 3 NAVIGATOR Studies
Authors: Chris Ambrose, Andrew Menzies-Gow, Bill Cook, Åsa Hellqvist, Stephanie Roseti, Nestor Molfino, Jean-Pierre Llanos-Ackert, Gene Colice, Jonathan Corren
Journal: Journal of Allergy and Clinical Immunology (2022)
Rare “Burned-Out” Testicular Mixed Germ Cell Tumor on 18F-FDG PET/CT
Authors: Yu-Chin Wu, Chia-Hung Kao, Shung-Shung Sun, Te-Chun Hsieh
Journal: Clinical Nuclear Medicine (2022)

Abstract Spontaneous regression of testicular mixed germ cell tumor is rare and is also called burned-out testicular tumor. We herein present the case of a 20-year-old man who was initially diagnosed with metastatic embryonal carcinoma. 18 F-FDG PET/CT demonstrated apparent metastases in the lymph node regions and both lungs. A covert right testicular lesion was noted according to the features on the CT component of PET/CT, which was subsequently confirmed as burned-out testicular mixed germ cell tumor.
National Preparedness Month — September 2019
Journal: MMWR Morbidity and Mortality Weekly Report (2019)

Every September, CDC, along with partners in government, private and public health, and academia observes National Preparedness Month, a public service reminder of the importance of personal and community preparedness for all events (1). This year, CDC's Center for Preparedness and Response has published a CDC Digital Media Toolkit (https://www.cdc.gov/cpr/npm/npm2019.htm) regarding personal health preparedness, including how to build an emergency supplies kit. In addition to food and water, an emergency supplies kit should include 1) personal needs (supplies necessary to protect physical, mental, and emotional health); 2) an emergency supply of prescription medications and medical supplies; 3) important paperwork including documentation of medical coverage, property ownership, and identity; and 4) backup and alternative power sources for mobile phones and medical devices.
Destruction of vitamin B12 by ascorbic acid
Authors: V. Herbert
Journal: JAMA (1974)

High doses of vitamin C, popularly used as a home remedy against the common cold, destroy substantial amounts of vitamin B when ingested with food. Because this undesirable effect is unequivocal when measured in vitro, while the value of ascorbic acid in preventing the common cold is highly equivocal, daily ingestion of 0.5 gm or more of ascorbic acid without regular evaluation of vitamin B<sub>12</sub>status is probably unwise. (<i>JAMA</i>230:241-242, 1974)
Other Books
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vaccination Coverage with Selected Vaccines and Exemption Rates Among Children in Kindergarten — United States, 2019–20 School Year
Authors: Ranee Seither, Michael T. McGill, Jennifer L. Kriss, Jenelle L. Mellerson, Caitlin Loretan, Kendra Driver, Cynthia L. Knighton, Carla L. Black
Journal: MMWR Morbidity and Mortality Weekly Report (2021)

State and local school vaccination requirements serve to protect students against vaccine-preventable diseases (1). This report summarizes data collected by state and local immunization programs* on vaccination coverage among children in kindergarten (kindergartners) in 48 states, exemptions for kindergartners in 49 states, and provisional enrollment and grace period status for kindergartners in 28 states for the 2019-20 school year, which was more than halfway completed when most schools moved to virtual learning in the spring because of the coronavirus 2019 (COVID-19) pandemic. Nationally, vaccination coverage† was 94.9% for the state-required number of doses of diphtheria and tetanus toxoids, and acellular pertussis vaccine (DTaP); 95.2% for 2 doses of measles, mumps, and rubella vaccine (MMR); and 94.8% for the state-required number of varicella vaccine doses. Although 2.5% of kindergartners had an exemption from at least one vaccine,§ another 2.3% were not up to date for MMR and did not have a vaccine exemption. Schools and immunization programs can work together to ensure that undervaccinated students are caught up on vaccinations in preparation for returning to in-person learning. This follow-up is especially important in the current school year, in which undervaccination is likely higher because of disruptions in vaccination during the ongoing COVID-19 pandemic (2-4).
Chemotherapy for lung cancer by intra-aortic infusion
Authors: H. A. Freckman
Journal: JAMA (1966)

Over a period of four years, 91 patients with inoperable or nonresectable lung cancer (55 bronchogenic and 36 metastatic) were treated by the continuous regional intra-aortic infusion of fluorouracil and cyclophosphamide, or both, for the purpose of increasing and prolonging the concentration of these agents in tumor-bearing areas supplied by the bronchial arteries. Twelve of the patients with bronchogenic cancer showed an objective response rate of 12.4 months' duration with an average survival time of 13.4 months. In the metastatic group, the cancers of 12 patients had an average objective regression of 12.5 months' duration with an average survival time of 14.5 months. A comparable retrospective study of the intravenous method of administration demonstrated no objective response (by our criteria) in 49 cases of bronchogenic and seven cases of metastatic lung cancer. Average survival time was 4.2 and 4.4 months, respectively.
Suspected Brucellosis Case Prompts Investigation of Possible Bioterrorism-Related Activity--New Hampshire and Massachusetts, 1999
Journal: JAMA (2000)

Brucella species, particularly B. melitensis and B. suis, are potential agents of biological terrorism (1,2). This report describes the public health and law enforcement assessment of a suspected case of brucellosis in a woman, in which the atypical clinical presentation and suspicious circumstances surrounding the case raised the possibility of biological terrorism. Although the investigation did not identify evidence of biological terrorism, the safe resolution of the case illustrates the value of integrated clinical, public health, and law enforcement biological terrorism preparedness and response.
Anti-RNP antibodies are associated with the interferon gene signature but not decreased complement levels in SLE
Authors: Erika L Hubbard, David S Pisetsky, Peter E Lipsky
Journal: Annals of the Rheumatic Diseases (2022)

The goals of these studies were to elucidate the inter-relationships of specific anti-nuclear antibody (ANA), complement, and the interferon gene signature (IGS) in the pathogenesis of systemic lupus erythematosus (SLE).Data from the Illuminate trials were analysed for antibodies to dsDNA as well as RNA-binding proteins (RBP), levels of C3, C4 and various IGS. Statistical hypothesis testing, linear regression analyses and classification and regression trees analysis were employed to assess relationships between the laboratory features of SLE.Inter-relationships of ANAs, complement and the IGS differed between patients of African Ancestry (AA) and European Ancestry (EA); anti-RNP and multiple autoantibodies were more common in AA patients and, although both related to the presence of the IGS, relationships between autoantibodies and complement differed. Whereas, anti-dsDNA had an inverse relationship to C3 and C4, levels of anti-RNP were not related to these markers. The IGS was only correlated with anti-dsDNA in EA SLE and complement was more correlated to the IGS in AA SLE. Finally, autoantibodies occurred in the presence and absence of the IGS, whereas the IGS was infrequent in anti-dsDNA/anti-RBP-negative SLE patients.There is a complex relationship between autoantibodies and the IGS, with anti-RNP associated in AA and both anti-dsDNA and RNP associated in EA. Moreover, there was a difference in the relationship between anti-dsDNA, but not anti-RBP, with complement levels. The lack of a relationship of anti-RNP with C3 and C4 suggests that anti-RNP immune complexes (ICs) may drive the IGS without complement fixation, whereas anti-dsDNA ICs involve complement consumption.
THE BEHAVIOR OF THE PYLORUS
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
How can we improve our operation?
Authors: Yonghao Chen, Lang Qu, Linjie Guo
Journal: Endoscopy (2022)

See also: Reply to Chen et al.Endoscopy 2022; 54(02): 223-223DOI: 10.1055/a-1722-2963 See also: Diagnostic accuracy of a novel artificial intelligence system for adenoma detection in daily practice: a prospective nonrandomized comparative studyEndoscopy 2022; 54(05): 465-472DOI: 10.1055/a-1556-5984
The Future of Clinical Trial Design in Oncology
Authors: Anna Spreafico, Aaron R. Hansen, Albiruni R. Abdul Razak, Philippe L. Bedard, Lillian L. Siu
Journal: Cancer Discovery (2021)

Clinical trials represent a fulcrum for oncology drug discovery and development to bring safe and effective medicines to patients in a timely manner. Clinical trials have shifted from traditional studies evaluating cytotoxic chemotherapy in largely histology-based populations to become adaptively designed and biomarker-driven evaluations of molecularly targeted agents and immune therapies in selected patient subsets. This review will discuss the scientific, methodological, practical, and patient-focused considerations to transform clinical trials. A call to action is proposed to establish the framework for next-generation clinical trials that strikes an optimal balance of operational efficiency, scientific impact, and value to patients. SIGNIFICANCE: The future of cancer clinical trials requires a framework that can efficiently transform scientific discoveries to clinical utility through applications of innovative technologies and dynamic design methodologies. Next-generation clinical trials will offer individualized strategies which ultimately contribute to globalized knowledge and collective learning, through the joint efforts of all key stakeholders including investigators and patients.
Hair Are the Rankings—5-α Reductase Inhibitors and Minoxidil in Male Androgenetic Alopecia
Authors: Kathie P. Huang, Maryanne M. Senna
Journal: JAMA Dermatology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
1999 Frank Netter Arts Contest for Medical Students
Journal: JAMA (1999)

A snake-entwined staff.The oath of Hippocrates.The clinical acumen of Osler and the compassionate service of Schweitzer.These are the symbols and personifications of our chosen profession.One symbol of medicine since antiquity has been the Aesculapian staff. 1 A glance through this journal will uncover the staff in the American Medical Association's emblem, depicting a snake coiled around the rough, knotty staff of the Greek physician Aesculapius.In this issue of MSJAMA, Nathan W. Williams explores the connection between snakes and the art of healing across cultures; Judith Anne Stanton introduces us to Aesculapius.Williams reveals that the serpent can represent the forces of both healing and destruction.Stanton demonstrates that society's alternating praise and distrust of the medical profession have been present throughout time and suggests that such ambivalence will continue.Valerie A. Jones turns her attention to another Greek healer, Hippocrates, who bestowed on modern medicine a legacy of ethical thought embodied in his famous oath.This pledge has become part of a new ceremony that Jones describes in her discussion of a second inherited symbol of the profession-the physician's white coat.Timothy Lahey, MD, argues that we must preserve the purity of the meaning behind such symbols as the white coat by always acting in the best interest of our patients.By exploring the symbols that form and influence the culture of medicine, we hope to come closer to the heart of what it means to be a physician.