tbuckley/cabot-search huggingface dataset:
Abstract IA12: Dynamic metabolic regulation of epigenetic remodeling in macrophages
Authors: Jing Fan
Journal: Cancer Research (2020)

Abstract Over the course of an immune response, macrophages undergo a sequence of functional transitions. These transitions are coupled to dynamic rewiring of cellular metabolism. The impact of metabolic state on chromatin modifications allows the dynamic metabolic reprogramming to orchestrate immunity during immune responses. Specifically, we found that in response to the classic stimuli lipopolysaccharide and interferon-γ, pyruvate dehydrogenase complex is profoundly inhibited over time, mediating the metabolic transition from the early pro-inflammatory stage to the later more immunosuppressive stage. The regulation of PDHC activity dynamically controls cellular acetyl-coA availability. We will discuss how this affects histone acetylation in macrophages over a course of prolonged stimulation and upon repeated stimulation. Furthermore, our study revealed that several metabolites directly involved in the addition or removal of histone methylation, such as S-adenosyl-methionine and succinate, show highly dynamic changes during the immune response. We will discuss which specific epigenetic modifications are sensitive to fluctuations in metabolite levels. This work reveals important mechanisms connecting metabolism, epigenetic and changes in macrophage functions during immune response. Citation Format: Jing Fan. Dynamic metabolic regulation of epigenetic remodeling in macrophages [abstract]. In: Abstracts: AACR Special Virtual Conference on Epigenetics and Metabolism; October 15-16, 2020; 2020 Oct 15-16. Philadelphia (PA): AACR; Cancer Res 2020;80(23 Suppl):Abstract nr IA12.
Computed Tomography to Analyze Mitral Valve: An Answer in Search of a Question⁎⁎Editorials published in JACC: Cardiovascular Imaging reflect the views of the authors and do not necessarily represent the views of JACC: Cardiovascular Imaging or the American College of Cardiology.
Authors: Frank A. Flachskampf, Dieter Ropers
Journal: JACC. Cardiovascular imaging (2009)
Phase 2 study of the safety and efficacy of umbralisib in patients with CLL who are intolerant to BTK or PI3Kδ inhibitor therapy
Authors: Anthony R. Mato, Nilanjan Ghosh, Stephen J. Schuster, Nicole Lamanna, John M. Pagel, Ian W. Flinn, Jacqueline C. Barrientos, Kanti R. Rai, James A. Reeves, Bruce D. Cheson, Paul M. Barr, Suman Kambhampati, Frederick Lansigan, Jeffrey J. Pu, Alan P. Skarbnik, Lindsey Roeker, Gustavo A. Fonseca, Andrea Sitlinger, Issam S. Hamadeh, Colleen Dorsey, Nicole LaRatta, Hanna Weissbrot, Eline T. Luning Prak, Patricia Tsao, Dana Paskalis, Peter Sportelli, Hari P. Miskin, Michael S. Weiss, Jakub Svoboda, Danielle M. Brander
Journal: Blood (2020)
From FAANG to fork: application of highly annotated genomes to improve farmed animal production
Authors: Emily L. Clark, Alan L. Archibald, Hans D. Daetwyler, Martien A. M. Groenen, Peter W. Harrison, Ross D. Houston, Christa Kühn, Sigbjørn Lien, Daniel J. Macqueen, James M. Reecy, Diego Robledo, Mick Watson, Christopher K. Tuggle, Elisabetta Giuffra
Journal: Genome biology (2020)
16846 Clinical evaluation, cutaneous homeostasis, and epidermal barrier analysis of a human tissue engineered skin substitute for severe burn patients
Authors: Salvador Arias-Santiago, Ana Fernández-González, Gloria Carmona PharmG, Purificación Gacto, Antonio M. Lizana-Moreno, Antonio Ruiz-Garcia, Natividad Cuende, Miguel Alaminos, Antonio Campos, Rosario Mata, Natividad Cuende
Journal: Journal of the American Academy of Dermatology (2020)
Electrical stimulation at nanoscale topography boosts neural stem cell neurogenesis through the enhancement of autophagy signaling
Authors: Liumin He, Zhongqing Sun, Jianshuang Li, Rong Zhu, Ben Niu, Ka Long Tam, Qiao Xiao, Jun Li, Wenjun Wang, Chi Ying Tsui, Vincent Wing Hong Lee, Kwok-Fai So, Ying Xu, Seeram Ramakrishna, Qinghua Zhou, Kin Chiu
Journal: Biomaterials (2020)
Abstract 254: Ultrasound Improves the Outcomes After Cardiopulmonary Resuscitation by Stimulating the Cholinergic Anti-Inflammatory Pathway
Authors: Peng Sun, Yuhan Zhang, Tingting Shu, Licai Liang, Weijing Shao, Lang Guo, Li Xu
Journal: Circulation (2018)

Introduction: Recently it was shown that the ultrasound (US) treatment prevented renal ischemia- reperfusion injury (IRI) in mice. In the present study, we investigated the effects of the US treatment against IRI after CPR . Hypothesis: US would improve the outcomes after resuscitation in a rat model of CPR, and the protective effect of US would be dependent on the cholinergic anti-inflammatory pathway (CAP) via α7nAChR. Methods: The animals were randomized into 5 groups (n=8 each): (1) CPR group: the rats underwent 6 mins of untreated ventricular fibrillation (VF) followed by CPR and defibrillation; (2) US group: the treatment was identical to the CPR group except that rats were exposed to US treatment 24h before CPR; (3) MLA group: the treatment was identical to the US group except thatα7nAChR antagonist MLA (4mg/kg) was administered 30 mins prior to US treatment and VF respectively; (4) GTS group: the treatment was identical to the CPR group except that α7nAChR agonist GTS-21(4mg/kg) was injected 30 mins before VF. (5) SHAM group: the rats were exposed to surgical preparation without CPR and US application. One day before CPR, the US treatment was delivered to the left kidney by US pulses (contrast general mode with 9 MHz) with a bursting mechanical index of 0.72. US pulses were 1 second in duration and were applied once every 6 seconds for 2 mins. After the treatment of the left kidney, the right kidney was exposed to US treatment for another 2 mins. Results: Significantly longer duration of survival was observed in US-treated animals. And US treatment also suppressed the TNF-α and IL-6 following resuscitation, and improved neurological function. The expression of α7nAChR were promoted in hippocampal neurons in US group. Moreover, the protective effect of US treatment could be abolished by MLA and imitated by GTS-21. Conclusions: US treatment before IRI improves the outcomes after CPR, and CAP via α7nAChR plays an important role during CPR.
426P A multicenter, randomized, double-blind, phase II study of lenvatinib (LEN) in patients (pts) with radioiodine-refractory differentiated thyroid cancer (RR-DTC) to evaluate the safety and efficacy of a daily oral starting dose of 18 mg vs 24 mg
Authors: M.S. Brose, Y. Panaseykin, B. Konda, C. de la Fouchardiere, B.G.M. Hughes, A.G. Gianoukakis, Y.J. Park, I. Romanov, M.K. Krzyzanowska, T. Binder, C. Dutcus, R. Xie, M.H. Taylor
Journal: Annals of Oncology (2020)
Abstract 11623: Reduced ERK1/2 and AP-1 Activity Contribute to Aortic Dilatation in Patients With Bicuspid Aortic Valve Disease
Authors: Stephanie W Tobin, Jie Wu, Shu-Hong Li, Jian Guo, Azadeh Yeganeh, Katherine Tsang, Laura Tumiati, Rodolfo Rocha, Jagdish Butany, Terrence M Yau, Maral Ouzounian, Tirone E David, Richard D Weisel, Ren-Ke Li
Journal: Circulation (2017)

Background: Bicuspid aortic valve (BAV) disease is a congenital abnormality that often leads to ascending aortic aneurysms. Previous studies suggest that aneurysm progression may be caused by a com...
Understanding the tumor microenvironment for effective immunotherapy
Authors: Habib Sadeghi Rad, James Monkman, Majid E. Warkiani, Rahul Ladwa, Ken O'Byrne, Nima Rezaei, Arutha Kulasinghe
Journal: Medicinal Research Reviews (2020)

Abstract Advances in immunotherapy have led to durable and long‐term benefits in a subset of patients across a number of solid tumor types. Understanding of the subsets of patients that respond to immune checkpoint inhibitors at the cellular level, and in the context of their tumor microenvironment (TME) is becoming increasingly important. The TME is composed of a heterogeneous milieu of tumor and immune cells. The immune landscape of the TME can inhibit or promote tumor initiation and progression; thus, a deeper understanding of tumor immunity is necessary to develop immunotherapeutic strategies. Recent developments have focused on characterizing the TME immune contexture (type, density, and function) to discover mechanisms and biomarkers that may predict treatment outcomes. This has, in part, been powered by advancements in spatial characterization technologies. In this review article, we address the role of specific immune cells within the TME at various stages of tumor progression and how the immune contexture determinants affecting tumor growth are used therapeutically.
14020 Durability of responses with bimekizumab, a selective dual inhibitor of interleukin-17A and -17F, in moderate to severe chronic plaque psoriasis in a 60-week randomized, double-blinded, phase 2b study (BE ABLE 2)
Authors: Andrew Blauvelt, Joseph F. Merola, Kim Alexander Papp, Melinda Gooderham, Alice B. Gottlieb, Christopher Cioffi, Luke Peterson, Nancy Cross, Christopher Griffiths, Diamant Thaci
Journal: Journal of the American Academy of Dermatology (2020)
Advocating for Black Lives—A Call to Dermatologists to Dismantle Institutionalized Racism and Address Racial Health Inequities
Authors: Robert J. Smith, Brittany U. Oliver
Journal: JAMA Dermatology (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Local blood coagulation drives cancer cell arrest and brain metastasis in a mouse model
Authors: Manuel J. Feinauer, Stefan W. Schneider, Anna S. Berghoff, Jose Ramon Robador, Cedric Tehranian, Matthia A. Karreman, Varun Venkataramani, Gergely Solecki, Julia Katharina Grosch, Katharina Gunkel, Bogdana Kovalchuk, Frank Thomas Mayer, Manuel Fischer, Michael O. Breckwoldt, Maik Brune, Yannick Schwab, Wolfgang Wick, Alexander T. Bauer, Frank Winkler
Journal: Blood (2020)
ATG5-Dependent Autophagy Uncouples T-cell Proliferative and Effector Functions and Separates Graft-versus-Host Disease from Graft-versus-Leukemia
Authors: Katherine Oravecz-Wilson, Corinne Rossi, Cynthia Zajac, Yaping Sun, Lu Li, Thomas Decoville, Hideaki Fujiwara, Stephanie Kim, Daniel Peltier, Pavan Reddy
Journal: Cancer Research (2020)

Abstract Autophagy is a vital cellular process whose role in T immune cells is poorly understood, specifically, in its regulation of allo-immunity. Stimulation of wild-type T cells in vitro and in vivo with allo-antigens enhances autophagy. To assess the relevance of autophagy to T-cell allo-immunity, we generated T-cell–specific Atg5 knock-out mice. Deficiency of ATG5-dependent autophagy reduced T-cell proliferation and increased apoptosis following in vitro and in vivo allo-stimulation. The absence of ATG5 in allo-stimulated T cells enhanced their ability to release effector cytokines and cytotoxic functions, uncoupling their proliferation and effector functions. Absence of autophagy reduced intracellular degradation of cytotoxic enzymes such as granzyme B, thus enhancing the cytotoxicity of T cells. In several in vivo models of allo-HSCT, ATG5-dependent dissociation of T-cell functions contributed to significant reduction in graft-versus-host disease (GVHD) but retained sufficient graft versus tumor (GVT) response. Our findings demonstrate that ATG5-dependent autophagy uncouples T-cell proliferation from its effector functions and offers a potential new strategy to enhance outcomes after allo-HSCT. Significance: These findings demonstrate that induction of autophagy in donor T-cell promotes GVHD, while inhibition of T-cell autophagy mitigates GVHD without substantial loss of GVL responses.
Coding Errors in Study of Meta-analyses With Falsified Data in the Results
Authors: Craig A. Garmendia
Journal: JAMA Internal Medicine (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Local IFNα enhances the anti-tumoral efficacy of systemic anti-PD1 to prevent tumor relapse
Authors: Marion v Guerin, Fabienne Regnier, Maxime Thoreau, Lene Vimeux, Matthieu Benard, Estelle Dransart, Hweixian L Penny, Ludger Johannes, Alain Trautmann, Nadege Bercovici
Journal: Journal for ImmunoTherapy of Cancer (2020)

Tumor relapse constitutes a major challenge for anti-tumoral treatments, including immunotherapies. Indeed, most cancer-related deaths occur during the tumor relapse phase. We designed a mouse model of tumor relapse in which mice transplanted with E7+ TC1 tumor cells received a single therapeutic vaccination of STxB-E7+IFNα. Unlike the complete regression observed after two vaccinations, such a treatment induced a transient shrinkage of the tumor mass, followed by a rapid tumor outgrowth. To prevent this relapse, we tested the efficacy of a local administration of IFNα together with a systemic therapy with anti-PD1 Ab. The immune response was analyzed during both the tumor regression and relapse phases. We show that, during the regression phase, tumors of mice treated with a single vaccination of STxB-E7 + IFNα harbor fewer activated CD8 T cells and monocytes than tumors doomed to fully regress after two vaccinations. In contrast, the systemic injection of an anti-PD1 Ab combined with the peri-tumoral injection of IFNα in this time frame promotes infiltration of activated CD8 T cells and myeloid cells, which, together, exert a high cytotoxicity in vitro against TC1 cells. Moreover, the IFNα and anti-PD1 Ab combination was found to be more efficient than IFNα or anti-PD1 used alone in preventing tumor relapse and was better able to prolong mice survival. Together, these results indicate that the local increase of IFNα in combination with an anti-PD1 therapy is an effective way to promote efficient and durable innate and adaptive immune responses preventing tumor relapse.
Single-cell RNA-seq reveals developmental plasticity with coexisting oncogenic states and immune evasion programs in ETP-ALL
Authors: Praveen Anand, Amy Guillaumet-Adkins, Valeriya Dimitrova, Huiyoung Yun, Yotam Drier, Noori Sotudeh, Anna Rogers, Madhu M. Ouseph, Monica Nair, Sayalee Potdar, Randi Isenhart, Jake A. Kloeber, Tushara Vijaykumar, Leili Niu, Tiffaney Vincent, Guangwu Guo, Julia Frede, Marian H. Harris, Andrew E. Place, Lewis B. Silverman, David T. Teachey, Andrew A. Lane, Daniel J. DeAngelo, Jon C. Aster, Bradley E. Bernstein, Jens G. Lohr, Birgit Knoechel
Journal: Blood (2020)
Population genomics and antimicrobial resistance in Corynebacterium diphtheriae
Authors: Melanie Hennart, Leonardo G. Panunzi, Carla Rodrigues, Quentin Gaday, Sarah L. Baines, Marina Barros-Pinkelnig, Annick Carmi-Leroy, Melody Dazas, Anne Marie Wehenkel, Xavier Didelot, Julie Toubiana, Edgar Badell, Sylvain Brisse
Journal: Genome Medicine (2020)

Abstract Background Corynebacterium diphtheriae , the agent of diphtheria, is a genetically diverse bacterial species. Although antimicrobial resistance has emerged against several drugs including first-line penicillin, the genomic determinants and population dynamics of resistance are largely unknown for this neglected human pathogen. Methods Here, we analyzed the associations of antimicrobial susceptibility phenotypes, diphtheria toxin production, and genomic features in C. diphtheriae . We used 247 strains collected over several decades in multiple world regions, including the 163 clinical isolates collected prospectively from 2008 to 2017 in France mainland and overseas territories. Results Phylogenetic analysis revealed multiple deep-branching sublineages, grouped into a Mitis lineage strongly associated with diphtheria toxin production and a largely toxin gene-negative Gravis lineage with few toxin-producing isolates including the 1990s ex-Soviet Union outbreak strain. The distribution of susceptibility phenotypes allowed proposing ecological cutoffs for most of the 19 agents tested, thereby defining acquired antimicrobial resistance. Penicillin resistance was found in 17.2% of prospective isolates. Seventeen (10.4%) prospective isolates were multidrug-resistant (≥ 3 antimicrobial categories), including four isolates resistant to penicillin and macrolides. Homologous recombination was frequent (r/m = 5), and horizontal gene transfer contributed to the emergence of antimicrobial resistance in multiple sublineages. Genome-wide association mapping uncovered genetic factors of resistance, including an accessory penicillin-binding protein (PBP2m) located in diverse genomic contexts. Gene pbp2m is widespread in other Corynebacterium species, and its expression in C. glutamicum demonstrated its effect against several beta-lactams. A novel 73-kb C. diphtheriae multiresistance plasmid was discovered. Conclusions This work uncovers the dynamics of antimicrobial resistance in C. diphtheriae in the context of phylogenetic structure, biovar, and diphtheria toxin production and provides a blueprint to analyze re-emerging diphtheria.
Advances in Diabetes Treatment — Once-Weekly Insulin
Authors: Peter A. Gottlieb, Aaron W. Michels
Journal: New England Journal of Medicine (2020)

The increasing incidence of type 2 diabetes and of health consequences related to complications from inadequate glycemic control is of major concern, even in the midst of a worldwide pandemic. Despite the introduction of new adjunctive medicines, recombinant insulins, and the ability to monitor blood glucose in real time, treatment for diabetes remains less than ideal.1 Data from the National Health and Nutrition Examination Survey (NHANES) indicate that the mean glycated hemoglobin level for adults with diabetes in the United States dropped to 7.2% in 2016; however, the percentage of patients in whom a target level of less than 7.0% . . .
Loss of alpha‐globin genes in human subjects is associated with improved nitric oxide‐mediated vascular perfusion
Authors: Christopher C. Denton, Payal Shah, Silvie Suriany, Honglei Liu, Wanwara Thuptimdang, John Sunwoo, Patjanaporn Chalacheva, Saranya Veluswamy, Roberta Kato, John C. Wood, Jon A. Detterich, Michael C. K. Khoo, Thomas D. Coates
Journal: American Journal of Hematology (2020)

Alpha thalassemia is a hemoglobinopathy due to decreased production of the α-globin protein from loss of up to four α-globin genes, with one or two missing in the trait phenotype. Individuals with sickle cell disease who co-inherit the loss of one or two α-globin genes have been known to have reduced risk of morbid outcomes, but the underlying mechanism is unknown. While α-globin gene deletions affect sickle red cell deformability, the α-globin genes and protein are also present in the endothelial wall of human arterioles and participate in nitric oxide scavenging during vasoconstriction. Decreased production of α-globin due to α-thalassemia trait may thereby limit nitric oxide scavenging and promote vasodilation. To evaluate this potential mechanism, we performed flow-mediated dilation and microvascular post-occlusive reactive hyperemia in 27 human subjects (15 missing one or two α-globin genes and 12 healthy controls). Flow-mediated dilation was significantly higher in subjects with α-trait after controlling for age (P = .0357), but microvascular perfusion was not different between groups. As none of the subjects had anemia or hemolysis, the improvement in vascular function could be attributed to the difference in α-globin gene status. This may explain the beneficial effect of α-globin gene loss in sickle cell disease and suggests that α-globin gene status may play a role in other vascular diseases.
74P Comprehensive transcriptome analysis of endoplasmic reticulum stress in osteosarcomas
Authors: Y. Suehara, T. Kurihara, T. Hayashi, K. Sano, K. Sasa, D. Kubota, K. Akaike, T. Okubo, Y. Kim, T. Saito
Journal: Annals of Oncology (2020)
Thromboembolic and Vascular Complications in Patients with Secondary Erythrocytosis Caused By High Oxygen Affinity Variant Hb Coimbra
Authors: Bruna Cunha Santos, Susan Elisabeth Jorge, Dulcinéia Martins de Albuquerque, Simone Cristina Olenscki Gilli, Maria de Fátima Sonati, Kleber Yotsumoto Fertrin, Fernando Ferreira Costa
Journal: Blood (2017)
Misfolded Transthyretin as a Novel Risk Factor for Heart Failure
Authors: Sanjiv J. Shah
Journal: JAMA Cardiology (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
389P Updated analysis from the KEYNOTE-042 China study: 1L pembrolizumab (pembro) vs chemotherapy (chemo) in Chinese patients (pts) with advanced NSCLC with PD-L1 TPS ≥1%
Authors: Y-L. Wu, L. Zhang, Y. Fan, J. Zhou, L. Zhang, Q. Zhou, W. Li, C. Hu, G. Chen, X. Zhang, C. Zhou, F. Souza, J. Lin, J. Wang, B. Li, T. Mok
Journal: Annals of Oncology (2020)
15285 Dupilumab with concomitant topical corticosteroids promotes rapid and sustained improvement in clinical signs in patients with moderate to severe atopic dermatitis: LIBERTY AD CHRONOS trial
Authors: Andrew Blauvelt, Thomas Bieber, Jamie Weisman, Zhen Chen, Brad Shumel, Ana Beatris Rossi
Journal: Journal of the American Academy of Dermatology (2020)