Treatment of Low Bone Density or Osteoporosis to Prevent Fractures
Authors: Amir Qaseem, Timothy J. Wilt
Journal: Annals of Internal Medicine (2021)

LettersAugust 2021Treatment of Low Bone Density or Osteoporosis to Prevent FracturesFREEAmir Qaseem, MD, PhD, MHA, Timothy J. Wilt, MD, MPHAmir Qaseem, MD, PhD, MHAAmerican College of Physicians, Philadelphia, PennsylvaniaSearch for more papers by this author, Timothy J. Wilt, MD, MPHMinneapolis VA Health Care System and University of Minnesota School of Medicine, Minneapolis, MinnesotaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L21-0434 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR: We are writing to notify readers that several studies included in the American College of Physicians' 2008 and 2017 guidelines on the treatment of low bone density and osteoporosis (1, 2) have been retracted. Seven studies contributed to the 2008 guideline “Pharmacologic Treatment of Low Bone Density or Osteoporosis to Prevent Fractures: A Clinical Practice Guideline From the American College of Physicians” (1), which expired in 2013, and 6 studies were included in the 2017 guideline “Treatment of Low Bone Density or Osteoporosis to Prevent Fractures in Men and Women: A Clinical Practice Guideline Update From the American College of Physicians” (2). More information is available on the publishing journals' websites and the Retraction Watch database (https://retractionwatch.com/retraction-watch-database-user-guide). We are uncertain of the effect of the retracted articles on our recommendations at this point. However, an update of the 2017 American College of Physicians guideline is currently under way and will exclude the retracted studies.The retracted studies cited in the 2008 guideline and their original reference numbers are as follows:54. Sato Y, Honda Y, Iwamoto J. Etidronate for fracture prevention in amyotrophic lateral sclerosis: a randomized controlled trial. Bone. 2006;39:1080-6. [PMID: 16777503] doi:10.1016/j.bone.2006.04.02555. Sato Y, Iwamoto J, Kanoko T, et al. Risedronate therapy for prevention of hip fracture after stroke in elderly women. Neurology. 2005;64:811-6. [PMID: 15753414]56. Sato Y, Iwamoto J, Kanoko T, et al. Risedronate sodium therapy for prevention of hip fracture in men 65 years or older after stroke. Arch Intern Med. 2005 Aug 8-22;165:1743-8. [PMID: 16087822]57. Sato Y, Iwamoto J, Kanoko T, et al. Alendronate and vitamin D2 for prevention of hip fracture in Parkinson's disease: a randomized controlled trial. Mov Disord. 2006;21:924-9. [PMID: 16538619]58. Sato Y, Kanoko T, Satoh K, et al. The prevention of hip fracture with risedronate and ergocalciferol plus calcium supplementation in elderly women with Alzheimer disease: a randomized controlled trial. Arch Intern Med. 2005 Aug 8-22;165:1737-42. [PMID: 16087821]59. Sato Y, Kanoko T, Yasuda H, et al. Beneficial effect of etidronate therapy in immobilized hip fracture patients. Am J Phys Med Rehabil. 2004;83:298-303. [PMID: 15024332]134. Sato Y, Asoh T, Kaji M, et al. Beneficial effect of intermittent cyclical etidronate therapy in hemiplegic patients following an acute stroke. J Bone Miner Res. 2000;15:2487-94. [PMID: 11127214]The retracted studies cited in the 2017 guideline and their original reference numbers are as follows:50. Sato Y, Honda Y, Iwamoto J. Risedronate and ergocalciferol prevent hip fracture in elderly men with Parkinson disease. Neurology. 2007;68:911-5. [PMID: 17372126]54. Sato Y, Kanoko T, Satoh K, et al. The prevention of hip fracture with risedronate and ergocalciferol plus calcium supplementation in elderly women with Alzheimer disease: a randomized controlled trial. Arch Intern Med. 2005 Aug 8-22;165:1737-42. [PMID: 16087821]198. Sato Y, Kuno H, Kaji M, et al. Effect of ipriflavone on bone in elderly hemiplegic stroke patients with hypovitaminosis D. Am J Phys Med Rehabil. 1999 Sep-Oct;78:457-63. [PMID: 10493456]199. Sato Y, Manabe S, Kuno H, et al. Amelioration of osteopenia and hypovitaminosis D by 1alpha-hydroxyvitamin D3 in elderly patients with Parkinson's disease. J Neurol Neurosurg Psychiatry. 1999;66:64-8. [PMID: 9886454]207. Sato Y, Iwamoto J, Kanoko T, et al. Low-dose vitamin D prevents muscular atrophy and reduces falls and hip fractures in women after stroke: a randomized controlled trial. Cerebrovasc Dis. 2005;20:187-92. [PMID: 16088114]215. Sato Y, Metoki N, Iwamoto J, et al. Amelioration of osteoporosis and hypovitaminosis D by sunlight exposure in stroke patients. Neurology. 2003;61:338-42. [PMID: 12913194]References1. Qaseem A, Snow V, Shekelle P, et al; Clinical Efficacy Assessment Subcommittee of the American College of Physicians. Pharmacologic treatment of low bone density or osteoporosis to prevent fractures: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2008;149:404-15. [PMID: 18794560] LinkGoogle Scholar2. Qaseem A, Forciea MA, McLean RM, et al; Clinical Guidelines Committee of the American College of Physicians. Treatment of low bone density or osteoporosis to prevent fractures in men and women: a clinical practice guideline update from the American College of Physicians. Ann Intern Med. 2017;166:818-39. [PMID: 28492856]. doi:10.7326/M15-1361 LinkGoogle Scholar Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: American College of Physicians, Philadelphia, PennsylvaniaMinneapolis VA Health Care System and University of Minnesota School of Medicine, Minneapolis, MinnesotaDisclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L21-0434.This article was published at Annals.org on 6 July 2021. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoTreatment of Low Bone Density or Osteoporosis to Prevent Fractures in Men and Women: A Clinical Practice Guideline Update From the American College of Physicians Amir Qaseem , Mary Ann Forciea , Robert M. McLean , Thomas D. Denberg , and Metrics Cited byIs abaloparatide more efficacious on increasing bone mineral density than teriparatide for women with postmenopausal osteoporosis? An updated meta-analysisA randomized trial alerting authors, with or without coauthors or editors, that research they cited in systematic reviews and guidelines has been retracted August 2021Volume 174, Issue 8Page: 1191-1192 ePublished: 6 July 2021 Issue Published: August 2021 Copyright & PermissionsCopyright © 2021 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...