tbuckley/cabot-search huggingface dataset:
Cardiac Computed Tomography versus 3D-Transesophageal Echocardiography in Preprocedural Planning of Left Atrial Appendage Closure
Authors: Jaroslaw Heinrich, Baravan Al-Kassou, Heyder Omran
Journal: Clinical Cardiology and Cardiovascular Interventions (2021)

Aim: Preprocedural imaging of the left atrial appendage (LAA) plays a crucial role in the process of LAA closure (LAAC). This study aimed to compare the influence of preprocedural planning of the LAAC with 3D-transesophageal echocardiography (TEE) and cardiac computed tomography (CCT) versus 3D-TEE alone in patients who underwent LAAC with an Amplatzer Cardiac Plug or Amulet. Materials and Methods: In a retrospective study, 176 patients received a preprocedural 3D-TEE and CCT and 167 patients a 3D-TEE only. Both groups had similar patient characteristics and indications for LAAC. Results: There was no difference in terms of procedural success, procedure time, amount of contrast medium, fluoroscopy time, or radiation dose. Patients with CCT/3D-TEE had a longer hospital stay on average. Besides, there was a different incidence of renal diseases (49% for 3D-TEE versus 27% for CCT/3D-TEE; p &lt; 0.001). The number of periprocedural adverse events was comparable. A device-related thrombus occurred three times in each group, and the peri-device leaks reported were similar. Conclusion: A preprocedural CCT does not decrease major adverse events or improve outcome in patients undergoing LAAC.
SVEP1 is a human coronary artery disease locus that promotes atherosclerosis
Authors: In-Hyuk Jung, Jared S. Elenbaas, Arturo Alisio, Katherine Santana, Erica P. Young, Chul Joo Kang, Puja Kachroo, Kory J. Lavine, Babak Razani, Robert P. Mecham, Nathan O. Stitziel
Journal: Science Translational Medicine (2021)

Reducing SVEP1 confers protection from atherosclerosis and may be a therapeutic target for the treatment and prevention of coronary artery disease.
Addressing the role of 11β-hydroxysteroid dehydrogenase type 1 in the development of polycystic ovary syndrome and the putative therapeutic effects of its selective inhibition in a preclinical model
Authors: Xinyu Li, Shuanggang Hu, Qinling Zhu, Guangxin Yao, Jufang Yao, Jiaxing Li, Yuan Wang, Ying Ding, Jia Qi, Rui Xu, Hanting Zhao, Zhenyi Zhu, Yanzhi Du, Kang Sun, Yun Sun
Journal: Metabolism (2021)
Venetoclax combination therapy induces deep AML remission with eradication of leukemic stem cells and remodeling of clonal haematopoiesis
Authors: Romain Vazquez, Claire Breal, Loria Zalmai, Chloe Friedrich, Carole Almire, Adrien Contejean, Sylvain Barreau, Eric Grignano, Lise Willems, Benedicte Deau-Fischer, Patricia Franchi, Marguerite Vignon, Justine Decroocq, Rudy Birsen, Lauriane Goldwirt, Sophie Kaltenbach, Lucile Couronne, Michaela Fontenay, Olivier Kosmider, Didier Bouscary, Nicolas Chapuis
Journal: Blood Cancer Journal (2021)
Evidence from a humanized mouse model of androgenetic alopecia that platelet‐rich plasma stimulates hair regrowth, hair shaft diameter and vellus‐to‐terminal hair reconversion <i>in vivo</i>
Authors: R. Laufer Britva, A. Keren, A. Ginzburg, Y. Ullmann, R. Paus, A. Gilhar
Journal: British Journal of Dermatology (2021)
Long-term Variability of Oscillatory Impedance in Stable Obstructive Airways Disease
Authors: Sandra Rutting, Tanya Badal, Ryan Wallis, Robin E. Schoeffel, Nicole Roche, Alice M. Cottee, David G. Chapman, Matthew Greenwood, Claude S. Farah, Gregory G. King, Cindy Thamrin
Journal: European Respiratory Journal (2021)

<b>FOT parameters have good long-term repeatability in patients with stable obstructive airways disease, facilitating its ability to detect sensitive changes in airways disease. Novel cut-off values presented may help determine clinically significant change.</b>https://bit.ly/3emL7FI
P36.07 Pleckstrin Homology-Like (PHLDA) Domain Family Members Immunoexpression as Prognostic Marker in Lung Cancer and Mesothelioma
Authors: C. Machado Baldavira, T. Prieto, M. Balancin, E. Eher, S. Fernezlian, P. Souza, M. Nagai, V. Capelozzi
Journal: Journal of Thoracic Oncology (2021)
Carfilzomib in Relapsed or Refractory Multiple Myeloma Patients with Early or Late Relapse Following Prior Therapy: A Subgroup Analysis of the Randomized Phase 3 Aspire and Endeavor Trials
Authors: Maria-Victoria Mateos, Hartmut Goldschmidt, Jesus F San Miguel, Joseph Mikhael, Lucy DeCosta, Lifen Zhou, Mihaela Obreja, Julie Blaedel, Zsolt Szabo, Xavier Leleu
Journal: Blood (2017)
Temperature variability and asthma hospitalisation in Brazil, 2000–2015: a nationwide case-crossover study
Authors: Yao Wu, Rongbin Xu, Bo Wen, Micheline de Sousa Zanotti Staglior Coelho, Paulo H Saldiva, Shanshan Li, Yuming Guo
Journal: Thorax (2021)

Background Both cold and hot temperature have been associated with the onset of asthma, but it remains largely unknown about the risk of asthma hospitalisation associated with short-term temperature fluctuation or temperature variability (TV). Objective To explore the association between short-term exposure to TV and asthma hospitalisation in Brazil. Methods Data for asthma hospitalisation and weather conditions were collected from 1816 Brazilian cities between 2000 and 2015. TV was calculated as the SD of all daily minimum and maximum temperatures within 0–7 days prior to current day. A time-stratified case-crossover design was performed to quantify the association between TV and hospitalisation for asthma. Results A total of 2 818 911 hospitalisations for asthma were identified during the study period. Each 1°C increase in 0–7 days’ TV exposure was related to a 1.0% (95% CI 0.7% to 1.4%) increase in asthma hospitalisations. The elderly were more vulnerable to TV than other age groups, while region and season appeared to significantly modify the associations. There were 159 305 (95% CI 55 293 to 2 58 054) hospitalisations, US$48.41 million (95% CI US$16.92 to US$78.30 million) inpatient costs at 2015 price and 450.44 thousand inpatient days (95% CI 156.08 to 729.91 thousand days) associated with TV during the study period. The fraction of asthma hospitalisations attributable to TV increased from 5.32% in 2000 to 5.88% in 2015. Conclusion TV was significantly associated with asthma hospitalisation and the corresponding substantial health costs in Brazil. Our findings suggest that preventive measures of asthma should take TV into account.
Abstract 2670: Time to Granulocyte-Colony Stimulating Factor Treatment after Acute Myocardial Infarction Does Not Affect Left Ventricular Recovery: Results from the STEMMI Trial
Authors: Rasmus S Ripa, Wang Yongzhong, Erik Jørgensen, Jens Kastrup
Journal: Circulation (2007)

Introduction: Granulocyte-colony stimulating factor (G-CSF) therapy after a STEMI does not affect left ventricular systolic function when compared to placebo. However, recent human and animal studies suggest that the timing of G-CSF therapy is crucial. Hypothesis: G-CSF improves recovery of left ventricular ejection fraction if administered very early after a STEMI. Methods: The STEMMI trial MRI-subpopulation was analyzed. The trial included 58 patients (47 men; 56 [SD 9] years) with STEMI treated with primary PCI &lt;12 hours after symptom onset. Patients were randomized to double blind treatment with G-CSF (10 μg/kg/day) or placebo for 6 days. Treatment with G-CSF (time to G-CSF) was initiated 30 hours (range 17 – 65) after PCI. Left ventricular function was evaluated with cardiac MRI and analyzed by an independent blinded core laboratory. Results: Circulating CD34+ cells increased during G-CSF therapy. However, there was no correlation between time to G-CSF and maximum plasma concentration of CD34+ cells (r=-0.3, p=0.2). Baseline ejection fraction was independent of time to G-CSF. The recovery of ejection fraction from baseline to 6 months was not associated with time to G-CSF (regression coefficient 0.2/hour, 95% CI -0.2 to 0.5), an identical improvement was found in the placebo group (p=0.8). There was no association between plasma concentrations of CD34+ cells and improvement in left ventricular function. Conclusions: We found no indication that early initiation of treatment with G-CSF improves recovery of left ventricular ejection fraction as compared to both late G-CSF and placebo. It remains to be determined if treatment initiation &lt;17 hours after PCI improves recovery.
Prognostic significance of cutaneous immune-related adverse events in patients with melanoma and other cancers on immune checkpoint inhibitors
Authors: Leah L. Thompson, Michael S. Chang, Nicole J. Polyakov, Amy E. Blum, Nathaniel Josephs, Nira A. Krasnow, Jaewon Yoon, Edward B. Li, Gabriel E. Molina, Jordan T. Said, Kevin Huang, Juhi R. Kuchroo, Andrea N. Hinton, Steven T. Chen
Journal: Journal of the American Academy of Dermatology (2021)
Investigation of a pertussis outbreak and comparison of two acellular booster pertussis vaccines in a junior school in South East England, 2019
Authors: Elise Tessier, Helen Campbell, Sonia Ribeiro, Nick Andrews, Julia Stowe, Margot Nicholls, Jaime Morgan, David Litt, Norman K Fry, Gayatri Amirthalingam
Journal: Eurosurveillance (2021)

In March 2019, a pertussis outbreak occurred in children in a junior school (7–11 years) in England who had been offered pertussis-containing booster vaccine at 40 months of age. In a case–control investigation, we assessed the extent of transmission and any difference in protection afforded to those who had previously received a booster 3- or 5-component acellular pertussis vaccine (aP). We took oral fluid specimens from the students to determine IgG antibodies against pertussis toxin (anti-PT). Parents of students attending the school were sent a questionnaire on pertussis symptoms and vaccination status was retrieved from general practitioner records for all students. Of 381 students, 134 (35.2%) were classified as pertussis cases, 133 by demonstration of significant anti-PT IgG titres and one clinically. There was no significant difference in the risk of pertussis between students receiving 3-component (33.7%) or 5-component (32.3%) aP boosters. However, pertussis infection differed significantly in school year 4, with 22.9%, 50.0%, 23.7% and 38.1% pertussis cases in years 3, 4, 5 and 6, respectively. The proportion of students with incomplete vaccinations recorded was higher than the proportion of those not covered according to the national reported coverage, possibly contributing to sustained transmission within the school.
Abstract 14604: Radiofrequency Delivery and Ablation Lesion Size Are Reduced by Ambient Circulation Surrounding an Ablation Catheter Tip
Authors: Matthew M Zipse, Ryan Borne, Lijun Zheng, Wendy S Tzou, William Sauer, Duy Nguyen
Journal: Circulation (2019)

Introduction: The ambient circulating environment (CE) surrounding an ablation catheter electrode may affect radiofrequency (RF) current. A higher flow CE around a catheter tip may impact RF of tar...
P21.14 The Promising role of Chemo-Immunotherapy in Non-Small Cell Lung Cancer Neoadjuvant Setting
Authors: H. Bote, A. Modrego, E. Jimenez-Aguilar, J.M. Mazarico, J.A. Núñez-Sobrino, L.C. Iglesias, J. Baena, J. Zugazagoitia, S. Ponce-Aix, L. Paz-Ares
Journal: Journal of Thoracic Oncology (2021)
P79.09 Neoadjuvant Combination Sintilimab plus Chemotherapy in Patients with Resectable Stage IIIA Non-Small Cell Lung Cancer.
Authors: K. Ma, C. Sun, X. Jia, X. Wang, Y. Xu, Y. Guo, S. Qiu, G. Shao, P. Zhang, Y. Liu, X. Ma
Journal: Journal of Thoracic Oncology (2021)
Endoscopic submucosal dissection and potential cancer dissemination
Authors: Kenneth K Wang
Journal: Gut (2021)

The recent report from the highly regarded interventional endoscopy group in Hamburg suggests that endoscopic submucosal dissection (ESD) can lead to dissemination of oesophageal adenocarcinoma (Ehlken H et al , Gut 2021, PMID: 33441377). This study reported the rapid recurrence of two cases of submucosal Barrett’s oesophagus (BO)-related adenocarcinoma treated with near-circumferential and circumferential ESD. The cancers had extensive recurrence at the base of the resection penetrating into the muscularis propria and even more alarming lymph node metastasis. The authors sequenced the tumours to demonstrate that the recurrences were similar to the primary tumour. They then performed additional studies to demonstrate that the endoscope might be the cause of seeding. The authors found that there was opportunity for seeding to occur through contaminated endoscopic biopsy channels by demonstrating malignant cytology could be found in the biopsy channels of 5/5 patients biopsied with advanced cancers by forceps.

It should be noted that trying to culture biopsy samples from BO biopsies is quite difficult, and tumour implantation is not a trivial biological event to achieve. Downstream tumour implantation (ie, in the stomach or duodenum) from an ESD for oesophageal cancer has not been reported to our knowledge. Furthermore, steroids that had been used after ESD procedures to prevent strictures were identified as one mechanism to potentially aid recurrence as the addition of steroids to oesophageal adenocarcinoma line cultures induced proliferation.

Despite this evidence, the clinical literature does not support dissemination of cancer …
FP04.03 Dynamic Liquid Biopsy for Selecting Advanced NSCLC Patients for Primary Tumor Resection After Targeted Therapy
Authors: W. Zhuang, L. Peng, Y. Ding, H. Xiao, Y. Tang, E. Xu, Z. He, Z. Ou, Q. Zhu, H. Wu, Z. Gao, S. Huang, G. Qiao
Journal: Journal of Thoracic Oncology (2021)
Delivering clinical research is “everyone’s business across the NHS,” says blueprint
Authors: Gareth Iacobucci
Journal: BMJ (2021)

All NHS staff should be empowered and supported to participate in clinical research as part of their job, a new UK government blueprint has said.

A document setting out1 a vision for the future of UK clinical research, published on 23 March, acknowledges that NHS staff are not always able to deliver research, and that participation in trials can be seen as the preserve of clinical academics and specialist research teams. “This has to change,” it says. “Whether helping to deliver a clinical trial, supporting patients to access the latest research opportunities, or adapting current practices in line with new findings—delivering research is everyone’s …
Serine biosynthesis defect due to haploinsufficiency of PHGDH causes retinal disease
Authors: Kevin Eade, Marin L. Gantner, Joseph A. Hostyk, Takayuki Nagasaki, Sarah Giles, Regis Fallon, Sarah Harkins-Perry, Michelle Baldini, Esther W. Lim, Lea Scheppke, Michael I. Dorrell, Carolyn Cai, Evan H. Baugh, Charles J. Wolock, Martina Wallace, Rebecca B. Berlow, David B. Goldstein, Christian M. Metallo, Martin Friedlander, Rando Allikmets
Journal: Nature Metabolism (2021)
Abstract 13075: A Novel Senolytic Drug, Seno-7284 Ameliorates Aging and Age-related Cardiometabolic Disorders
Authors: Goro Katsuumi, Masayoshi Suda, Ippei Shimizu, Yohko Yoshida, Yuka Hayashi, Masaaki Nakao, Ryo Furuuchi, Yang-Ting Hsiao, Tohru Minamino
Journal: Circulation (2020)

Introduction: Recent studies have shown elimination of senescent cells, so-called "senolysis" has the potential to become a novel therapy for aging and age-related disorders. However, there is no senolytic drug available in clinical settings currently. Purpose: The present study was aimed to identify a novel senolytic reagent effective for cardiometabolic disease among compounds already available in clinical settings. Here we identified a compound called "seno-7284" which exhibits senolytic effect in murine models of aging and age-related cardiometabolic disorders. Methods: We generated diet-induced obese(DIO) mice model by imposing high-fat diet, atherosclerotic mice model by imposing western diet to ApoE knockout mice. We administered seno-7284 mixed in the diet (0.03% w/w) to each mouse model for 1, 2 or 4 weeks. We harvested tissue samples for molecular biological analysis after measuring glucose/insulin tolerance. We also administered seno-7284 to Zmpste24 homozygous knockout mice as a progeroid mice model from 12-week-old to measure lifespan and to wild-type mice from 1-year-old for 20 weeks to measure physical function. Results: Seno-7284 reduced accumulation of senescent cells in visceral adipose tissue of DIO mice as senescence-associated beta-galactosidase (SA-beta-gal) staining exhibits (figure(fig) a), resulting in improvement of glucose metabolism (fig b). We also found seno-7284 reduced accumulation of senescent cells in the aorta of atherosclerotic mice model (fig c) and inhibited advancing atherosclerosis (fig d). Furthermore, Seno-7284 improved lifespan of progeroid mice (fig e) and physical function of aged mice (fig f). Further analysis including RNA-seq speculated seno-7284 stimulates endogenous senolytic function of immune cells. Conclusion: Our results indicate that seno-7284 would become a promising senolytic drug that exhibits novel therapeutic machinery for aging and age-related cardiometabolic diseases.
P18.03 Randomized Trial With BIALOE to Prevent Esophagitis in Lung Cancer Patients Treated With Concurrent Radical Chemoradiotherapy
Authors: F. Casas, J. Jové, N. Toscas, D. Muñoz Guglielmetti, T. Barreto, F. Pagan, M. Mollà
Journal: Journal of Thoracic Oncology (2021)
Direct conversion of adult human fibroblasts into functional endothelial cells using defined factors
Authors: Jung-Kyu Han, Youngchul Shin, Min-Hwan Sohn, Saet-Byeol Choi, Dasom Shin, Youngrang You, Jong-Yeon Shin, Jeong-Sun Seo, Hyo-Soo Kim
Journal: Biomaterials (2021)
A Phase 3 Open-Label Study of Elexacaftor/Tezacaftor/Ivacaftor in Children 6 through 11 Years of Age with Cystic Fibrosis and at Least One <i>F508del</i> Allele
Authors: Edith T. Zemanick, Jennifer L. Taylor-Cousar, Jane Davies, Ronald L. Gibson, Marcus A. Mall, Edward F. McKone, Paul McNally, Bonnie W. Ramsey, Jonathan H. Rayment, Steven M. Rowe, Elizabeth Tullis, Neil Ahluwalia, Chenghao Chu, Thang Ho, Samuel M. Moskowitz, Sabrina Noel, Simon Tian, David Waltz, Tanya G. Weinstock, Fengjuan Xuan, Claire E. Wainwright, Susanna A. McColley
Journal: American Journal of Respiratory and Critical Care Medicine (2021)

Rationale: Elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) was shown to be efficacious and safe in patients ≥12 years of age with cystic fibrosis and at least one F508del-CFTR (cystic fibrosis transmembrane conductance regulator) allele, but it has not been evaluated in children <12 years of age. Objectives: To assess the safety, pharmacokinetics, and efficacy of ELX/TEZ/IVA in children 6 through 11 years of age with F508del-minimal function or F508del-F508del genotypes. Methods: In this 24-week open-label phase 3 study, children (N = 66) weighing <30 kg received 50% of the ELX/TEZ/IVA adult daily dose (ELX 100 mg once daily, TEZ 50 mg once daily, and IVA 75 mg every 12 h) whereas children weighing ⩾30 kg received the full adult daily dose (ELX 200 mg once daily, TEZ 100 mg once daily, and IVA 150 mg every 12 h). Measurements and Main Results: The primary endpoint was safety and tolerability. The safety and pharmacokinetic profiles of ELX/TEZ/IVA were generally consistent with those observed in older patients. The most commonly reported adverse events included cough, headache, and pyrexia; in most of the children who had adverse events, these were mild or moderate in severity. Through Week 24, ELX/TEZ/IVA treatment improved the percentage of predicted FEV1 (10.2 percentage points; 95% confidence interval [CI], 7.9 to 12.6), Cystic Fibrosis Questionnaire-Revised respiratory domain score (7.0 points; 95% CI, 4.7 to 9.2), lung clearance index2.5 (-1.71 units; 95% CI, -2.11 to -1.30), and sweat chloride (-60.9 mmol/L; 95% CI, -63.7 to -58.2); body mass index-for-age z-score increased over the 24-week treatment period when compared with the pretreatment baseline. Conclusions: Our results show ELX/TEZ/IVA is safe and efficacious in children 6 through 11 years of age with at least one F508del-CFTR allele, supporting its use in this patient population. Clinical trial registered with www.clinicaltrials.gov (NCT03691779).
QIM21-086: Implementation of Depression Screening With the Patient Health Questionnaire-9 (PHQ-9) at a Radiation Oncology Department
Authors: Henry Eromosele Inegbenosun, Mary Tlasek-Wolfson
Journal: Journal of the National Comprehensive Cancer Network (2021)

"QIM21-086: Implementation of Depression Screening With the Patient Health Questionnaire-9 (PHQ-9) at a Radiation Oncology Department" published on 17 Mar 2021 by National Comprehensive Cancer Network.
P25.09 Effectiveness of Tumor Treating Fields plus Cisplatin/Pemetrexed Combination in Mesothelioma, in Vitro and in Vivo
Authors: H. Mumblat, A. Martinez, M. Munster, E. Dor-On, R. Schneiderman, Y. Porat, T. Voloshin, S. Davidi, R. Blatt, A. Shteingauz, C. Tempel-Brami, E. Zeevi, C. Lajterer, Y. Shmueli, S. Danilov, A. Haber, M. Giladi, U. Weinberg, Y. Palti
Journal: Journal of Thoracic Oncology (2021)
Abstract 12087: Trends, Outcomes and Predictors of Utilization of Electrical Cardioversion in Patients Hospitalized for Atrial Fibrillation: Nis Database 2005-2014
Authors: Harshil Shah, Shantanu Solanki, Achint Patel, Hee Kong Fong, Edo N Kaluski
Journal: Circulation (2019)

Introduction: Electrical cardioversion (EC) is a mainstay of therapy for subjects with atrial fibrillation(AF). Since data regarding the utilization of EC in AF is scarce this study was planned to ...
Authors’ Reply
Authors: Meagan L. Adamsick, Roby P. Bhattacharyya, Meghan E. Sise
Journal: Journal of the American Society of Nephrology (2021)

In their letter, Gevers and colleagues[1][1] highlight concerns that remdesivir and its metabolite, GS-441524, may carry a risk of toxicity to the renal tubular epithelium, and that risks may be more considerable for patients with predialysis CKD. We agree that the potential risks of remdesivir and
Ethical and Professionalism Implications of Physician Employment and Health Care Business Practices: A Policy Paper From the American College of Physicians
Authors: Matthew DeCamp, Lois Snyder Sulmasy
Journal: Annals of Internal Medicine (2021)

The environment in which physicians practice and patients receive care continues to change. Increasing employment of physicians, changing practice models, new regulatory requirements, and market dynamics all affect medical practice; some changes may also place greater emphasis on the business of medicine. Fundamental ethical principles and professional values about the patient–physician relationship, the primacy of patient welfare over self-interest, and the role of medicine as a moral community and learned profession need to be applied to the changing environment, and physicians must consider the effect the practice environment has on their ethical and professional responsibilities. Recognizing that all health care delivery arrangements come with advantages, disadvantages, and salient questions for ethics and professionalism, this American College of Physicians policy paper examines the ethical implications of issues that are particularly relevant today, including incentives in the shift to value-based care, physician contract clauses that affect care, private equity ownership, clinical priority setting, and physician leadership. Physicians should take the lead in helping to ensure that relationships and practices are structured to explicitly recognize and support the commitments of the physician and the profession of medicine to patients and patient care.
Top authors in dermatology: Comparisons of standardized database citation indicators
Authors: Mindy D. Szeto, Torunn E. Sivesind, Colby L. Presley, Taylor Harp, Abigail L. Meckley, Antara Afrin, Steven M. Lada, Melissa R. Laughter, Mayra B.C. Maymone, Robert P. Dellavalle
Journal: Journal of the American Academy of Dermatology (2021)