tbuckley/cabot-search huggingface dataset:
Readmissions From Venous Thromboembolism After Complex Cancer Surgery
Authors: Saad Mallick, Taylor Aiken, Patrick Varley, Daniel Abbott, Ching-Wei Tzeng, Sharon Weber, Nabil Wasif, Syed Nabeel Zafar
Journal: JAMA Surgery (2022)

Venous thromboembolism (VTE) is a major cause of preventable morbidity and mortality after cancer surgery. Venous thromboembolism events that are significant enough to require hospital readmission are potentially life threatening, yet data regarding the frequency of these events beyond the 30-day postoperative period remain limited.To determine the rates, outcomes, and predictive factors of readmissions owing to VTE up to 180 days after complex cancer operations, using a national data set.A retrospective cohort study of the 2016 Nationwide Readmissions Database was performed to study adult patients readmitted with a primary VTE diagnosis. Data obtained from 197 510 visits for 126 104 patients were analyzed. This was a multicenter, population-based, nationally representative study of patients who underwent a complex cancer operation (defined as cystectomy, colectomy, esophagectomy, gastrectomy, liver/biliary resection, lung/bronchus resection, pancreatectomy, proctectomy, prostatectomy, or hysterectomy) from January 1 through September 30, 2016, for a corresponding cancer diagnosis.Readmission with a primary diagnosis of VTE.Proportion of 30-, 90-, and 180-day VTE readmissions after complex cancer surgery, factors associated with readmissions, and outcomes observed during readmission visit, including mortality, length of stay, hospital cost, and readmission to index vs nonindex hospital.For the 126 104 patients included in the study, 30-, 90-, and 180-day VTE-associated readmission rates were 0.6% (767 patients), 1.1% (1331 patients), and 1.7% (1449 of 83 337 patients), respectively. A majority of patients were men (58.7%), and the mean age was 65 years (SD, 11.5 years). For the 1331 patients readmitted for VTE within 90 days, 456 initial readmissions (34.3%) were to a different hospital than the index surgery hospital, median length of stay was 5 days (IQR, 3-7 days), median cost was $8102 (IQR, $5311-$10 982), and 122 patients died (9.2%). Independent factors associated with readmission included type of operation, scores for severity and risk of mortality, age of 75 to 84 years (odds ratio [OR], 1.30; 95% CI, 1.02-1.78), female sex (OR, 1.23; 95% CI, 1.11-1.37), nonelective index admission (OR, 1.31; 95% CI, 1.03-1.68), higher number of comorbidities (OR, 1.30; 95% CI, 1.06-1.60), and experiencing a major postoperative complication during the index admission (OR, 2.08; 95% CI, 1.85-2.33).In this cohort study, VTE-related readmissions after complex cancer surgery continued to increase well beyond 30 days after surgery. Quality improvement efforts to decrease the burden of VTE in postoperative patients should measure and account for these late VTE-related readmissions.
Surfactant protein C mutations and familial pulmonary fibrosis: stuck in a loop on the scenic route
Authors: Bibek Gooptu
Journal: European Respiratory Journal (2022)

<b>Dysfunction in protein folding and intracellular processing are important mediators of disease. Detailed characterisation of SP-C deficiency mutations illuminates a pathway to alveolar epithelial cell damage that triggers familial pulmonary fibrosis.</b>https://bit.ly/3KavSgu
Toward Improving Patients’ Experiences of Acute Toxicity From Breast Radiotherapy: Insights From the Analysis of Patient-Reported Outcomes in a Large Multicenter Cohort
Authors: Reshma Jagsi, Kent A. Griffith, Frank Vicini, Thomas Boike, Jacob Burmeister, Michael M. Dominello, Inga Grills, James A. Hayman, Jean M. Moran, Peter Paximadis, Jeffrey D. Radawski, Eleanor M. Walker, Lori J. Pierce
Journal: Journal of Clinical Oncology (2020)

Understanding acute toxicities after whole-breast radiotherapy is important to inform patients, guide treatment decisions, and target supportive care. We evaluated patient-reported outcomes prospectively collected from a cohort of patients with breast cancer.We describe the maximal toxicity reported by 8,711 patients treated between 2012 and 2019 at 27 practices. Multivariable models identified characteristics associated with (1) breast pain, (2) bother from itching, stinging/burning, swelling, or hurting of the treated breast, and (3) fatigue within 7 days of completing whole-breast radiotherapy.Moderate or severe breast pain was reported by 3,233 (37.1%): 1,282 (28.9%) of those receiving hypofractionation and 1,951 (45.7%) of those receiving conventional fractionation. Frequent bother from at least one breast symptom was reported by 4,424 (50.8%): 1,833 (41.3%) after hypofractionation and 2,591 (60.7%) after conventional fractionation. Severe fatigue was reported by 2,008 (23.1%): 843 (19.0%) after hypofractionation and 1,165 (27.3%) after conventional fractionation. Among patients receiving hypofractionated radiotherapy, younger age (P < .001), higher body mass index (BMI; P < .001), Black (P < .001) or other race (P = .002), smoking status (P < .001), larger breast volume (P = .002), lack of chemotherapy receipt (P = .004), receipt of boost treatment (P < .001), and treatment at a nonteaching center predicted breast pain. Among patients receiving conventionally fractionated radiotherapy, younger age (P < .001), higher BMI (P = .003), Black (P < .001) or other race (P = .002), diabetes (P = .001), smoking status (P < .001), and larger breast volume (P < .001) predicted breast pain.In this large observational data set, substantial differences existed according to radiotherapy dose fractionation. Race-related differences in pain existed despite controlling for multiple other factors; additional research is needed to understand what drives these differences to target potentially modifiable factors. Intensifying supportive care may be appropriate for subgroups identified as being vulnerable to greater toxicity.
Fatal Case of Unsuspected Pertussis Diagnosed From a Blood Culture—Minnesota, 2003
Journal: JAMA (2004)

Pertussis (i.e., whooping cough) is a prolonged cough illness caused by the bacteria Bordetella pertussis and associated typically with an inspiratory "whoop," paroxysmal cough, and posttussive vomiting. B. pertussis can cause severe illness or death, especially in infants who have not completed their pertussis vaccination series. Adolescents (i.e., persons aged 13-17 years), adults, and recently vaccinated persons often report atypical symptoms, resulting in delay of recognition and creation of infectious reservoirs for further transmission. In 2003, the Minnesota Department of Health (MDH) investigated a fatal case of unsuspected B. pertussis infection in an elderly adult. This report summarizes the case investigation, which documents the rare isolation of B. pertussis from blood and underscores the need for clinicians to consider pertussis infection in adolescents and adults who have a prolonged cough illness.
Neural network-based integration of polygenic and clinical information: development and validation of a prediction model for 10-year risk of major adverse cardiac events in the UK Biobank cohort
Authors: Jakob Steinfeldt, Thore Buergel, Lukas Loock, Paul Kittner, Greg Ruyoga, Julius Upmeier zu Belzen, Simon Sasse, Henrik Strangalies, Lara Christmann, Noah Hollmann, Benedict Wolf, Brian Ference, John Deanfield, Ulf Landmesser, Roland Eils
Journal: The Lancet Digital Health (2022)

BackgroundIn primary cardiovascular disease prevention, early identification of high-risk individuals is crucial. Genetic information allows for the stratification of genetic predispositions and lifetime risk of cardiovascular disease. However, towards clinical application, the added value over clinical predictors later in life is crucial. Currently, this genotype–phenotype relationship and implications for overall cardiovascular risk are unclear.MethodsIn this study, we developed and validated a neural network-based risk model (NeuralCVD) integrating polygenic and clinical predictors in 395 713 cardiovascular disease-free participants from the UK Biobank cohort. The primary outcome was the first record of a major adverse cardiac event (MACE) within 10 years. We compared the NeuralCVD model with both established clinical scores (SCORE, ASCVD, and QRISK3 recalibrated to the UK Biobank cohort) and a linear Cox-Model, assessing risk discrimination, net reclassification, and calibration over 22 spatially distinct recruitment centres.FindingsThe NeuralCVD score was well calibrated and improved on the best clinical baseline, QRISK3 (ΔConcordance index [C-index] 0·01, 95% CI 0·009–0·011; net reclassification improvement (NRI) 0·0488, 95% CI 0·0442–0·0534) and a Cox model (ΔC-index 0·003, 95% CI 0·002–0·004; NRI 0·0469, 95% CI 0·0429–0·0511) in risk discrimination and net reclassification. After adding polygenic scores we found further improvements on population level (ΔC-index 0·006, 95% CI 0·005–0·007; NRI 0·0116, 95% CI 0·0066–0·0159). Additionally, we identified an interaction of genetic information with the pre-existing clinical phenotype, not captured by conventional models. Additional high polygenic risk increased overall risk most in individuals with low to intermediate clinical risk, and age younger than 50 years.InterpretationOur results demonstrated that the NeuralCVD score can estimate cardiovascular risk trajectories for primary prevention. NeuralCVD learns the transition of predictive information from genotype to phenotype and identifies individuals with high genetic predisposition before developing a severe clinical phenotype. This finding could improve the reprioritisation of otherwise low-risk individuals with a high genetic cardiovascular predisposition for preventive interventions.FundingCharité–Universitätsmedizin Berlin, Einstein Foundation Berlin, and the Medical Informatics Initiative.
NAT10 promotes cell proliferation by acetylating CEP170 mRNA to enhance translation efficiency in multiple myeloma
Authors: Rongfang Wei, Xing Cui, Jie Min, Zigen Lin, Yanyan Zhou, Mengjie Guo, Xiaojuan An, Hao Liu, Siegfried Janz, Chunyan Gu, Hongbo Wang, Ye Yang
Journal: Acta Pharmaceutica Sinica B (2022)

Multiple myeloma (MM) is still an incurable hematologic malignancy, which is eagerly to the discovery of novel therapeutic targets and methods. N-acetyltransferase 10 (NAT10) is the first reported regulator of mRNA acetylation that is activated in many cancers. However, the function of NAT10 in MM remains unclear. We found significant upregulation of NAT10 in MM patients compared to normal plasma cells, which was also highly correlated with MM poor outcome. Further enforced NAT10 expression promoted MM growth in vitro and in vivo, while knockdown of NAT10 reversed those effects. The correlation analysis of acetylated RNA immunoprecipitation sequencing (acRIP-seq) and ribosome profiling sequencing (Ribo-seq) combined with RIP-PCR tests identified centrosomal protein 170 (CEP170) as an important downstream target of NAT10. Interfering CEP170 expression in NAT10-OE cells attenuated the acceleration of cellular growth caused by elevated NAT10. Moreover, CEP170 overexpression promoted cellular proliferation and chromosomal instability (CIN) in MM. Intriguingly, remodelin, a selective NAT10 inhibitor, suppressed MM cellular growth, induced cellular apoptosis in vitro and prolonged the survival of 5TMM3VT mice in vivo. Collectively, our data indicate that NAT10 acetylates CEP170 mRNA to enhance CEP170 translation efficiency, which suggests that NAT10 may serve as a promising therapeutic target in MM.
Working for healthier lungs. The 1989 winter meeting of the British Thoracic Society. 7 and 8 December, London. Abstracts.
Authors: R Miller, A Millar, P Shaw, Sjg Semple, T Leigh, J Wiggins, J Midgeley, N Francis, D Shanson, T Evans, J Collins, Mta Villar, P Carvalho, D Smith, Jv Westminster, P Barnes, C Armour, L Alouan, P Johnson, J Black, N Choudry, R Fuller, S Mary's Bsc
Journal: Thorax (1990)

The differentiation between Pneumocystis carinii pneumonia (PCP) and Kaposi's sarcoma can be difficult if an HIV positive patient presents with alveolar consolidation and/or interstitial shadowing on the chest radio- graph (CXR).We have compared the CXR and thoracic computed tomographic (CT) appearances of 31 HIV positive males during acute respiratory episodes in order to evaluate the role of CT in distinguishing PCP from Kaposi's sarcoma.In group 1 sixteen patients had PCP.Eleven patients in group 2 had Kaposi's sarcoma and in group 3 four patients had both PCP and Kaposi's sarcoma.Both CXR and CT were categorised as being normal (N) or showing one or more of the following abnormalities: interstitial shadow- ing (INT); alveolar consolidation (ALV); intrapulmonary nodules < 1 cm diameter (NOD); mediastinal and/or hilar lymphadenopathy (LN); pleural effusions (EFF); cystic air spaces (C); and on CT bronchial wall thickening (BT).Results were as follows: Interstitial shadowing, alveolar consolidation and intrapulmonary nodules do not help distinguish Kaposi's sarcoma from PCP.The presence of bronchial wall thickening and cystic air spaces suggest a diagnosis of PCP whereas pleural effusions and lymphadenopathy suggests Kaposi's sarcoma.These abnormalities, which are better demonstrated by CT, help distinguish PCP from intrapul- monary Kaposi's sarcoma.N INTALVNODLNEFF C BT Group I CXR 0 14 4 1 1 2 3 0 (n= 16) CT 0 14 10 7 5 2 6 9 Group2 CXR0 9 5 5 2 7 0 0 (n= 11) C 0 O 9 5 9
Leads from the MMWR. Mumps--United States, 1984-1985
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Books Received
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cost Effectiveness of Mailed Outreach Programs for Colorectal Cancer Screening: Analysis of a Pragmatic, Randomized Trial
Authors: Kandice A Kapinos, Ethan A Halm, Caitlin C Murphy, Noel O Santini, Adam C Loewen, Celette Sugg Skinner, Amit G Singal
Journal: Clinical Gastroenterology and Hepatology (2022)
Postpartum Contraceptive Use Among US Medicaid Recipients
Authors: Maria I. Rodriguez, Thomas Meath, Kelsey Watson, Ashley Daly, Kyle Tracy, K. John McConnell
Journal: JAMA Network Open (2022)

This cohort study was conducted from January 1 to August 31, 2021.We determined the rate of postpartum contraceptive use by state or territory to categorize our findings.We excluded 6 states and territories with data assessed as "unusable" or "high concern" by using standardized quality assessments from the Center for Medicaid Services. 4Our data set included all live births to Medicaid recipients aged 15 to 44 years in 2016.The institutional review board at Oregon Health & Science University, Portland, approved the study.
PNEUMONIA AMONG FILIPINOS TRAVELING IN THE STEERAGE
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Principles of Bacteriology and Immunity.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The horizon of bone organoid: A perspective on construction and application
Authors: Shuangshuang Chen, Xiao Chen, Zhen Geng, Jiacan Su
Journal: Bioactive Materials (2022)

Bone defects repair and regeneration by various causes such as tumor resection, trauma, degeneration, etc. have always been a key issue in the clinics. As one of the few organs that can regenerate after adulthood, bone itself has a strong regenerative ability. In recent decades, bone tissue engineering technology provides various types of functional scaffold materials and seed cells for bone regeneration and repair, which significantly accelerates the speed and quality of bone regeneration, and many clinical problems are gradually solved. However, the bone metabolism mechanism is complicated, the research duration is long and difficult, which significantly restricts the progress of bone regeneration and repair research. Organoids as a new concept, which is built in vitro with the help of tissue engineering technology based on biological theory, can simulate the complex biological functions of organs in vivo. Once proposed, it shows broad application prospects in the research of organ development, drug screening, mechanism study, and so on. As a complex and special organ, bone organoid construction itself is quite challenging. This review will introduce the characteristics of bone microenvironment, the concept of organoids, focus on the research progress of bone organoids, and propose the strategies for bone organoid construction, study direction, and application prospects.
Book Review Die Chirurgie . A comprehensive presentation of General and Special Surgery. Edited by Prof. Dr. M. Kirschner Türingen and Prof. Dr. O. Nordman, Berlin. Section 24. Vol. 2, Part 2, pages 1421-1582 with 43 illustrations in the text and 5 color plates. Contents: Surgery of the Heart and Pericardium, Prof. Dr. Ed. Rehn Dusseldorf. Surgery of the Arteries and Veins, Prof. Dr. R. Stich Göttingen, Prof. Dr. W. V. Gaza Rostock i.m. Published by Urban and Schwarzenberg, Berlin.
Journal: New England Journal of Medicine (1929)
Books Received
Journal: JNCI Journal of the National Cancer Institute (1968)

Books Received Get access Preclinical Carcinoma of the Cervix Uteri. By Coppleson Malcolm and Reid Bevan. 321 p., $15.00. Pergamon Press Ltd., Headington Hill Hall, Oxford, England, 1967. Team Nursing: A Programmed Learning Experience. By Swansburg Russell C.. 4 paperback volumes, 640 p., $9.00. G. P. Putnam's Sons, 200 Madison Avenue, New York, N.Y. 10016, 1968. Bladder Cancer: A Symposium. By Diechmann William B.. 296 p., $15.00. Aesculapius Publishing Company, 903 South 21st Street, Birmingham, Alabama 35205, 1967. Proceedings of the Fifth Berkeley Symposium on Mathematical Statistics and Probability. Vol. IV. Biology and Problems of Health. Edited by Le Cam Lucien and Neyman Jerzy. 934 p., $28.50. University of California Press, Berkeley, California 94720, 1967. Advances in Biology of Skin. Vol. VIII. The Pigmentary System. Edited by Montagna William and Hu Funan. 659 p., $27.00. Pergamon Press Ltd., Headington Hill Hall, Oxford, England, 1968. The Ultrastructure of the Animal Cell. By Threadgold L. T.. 313 p., $13.00. Pergamon Press Ltd., Headington Hill Hall, Oxford, England, 1968. Histocompatibility Testing 1967. Edited by Curtoni E. S., Mattiuz P. L., and Tosi R. M.. 458 p., $24.50. The Williams & Wilkins Company, 428 East Preston Street, Baltimore, Maryland 21202, 1967. Cancer Epidemiology: Methods of Study. By Lilienfeld Abraham M., Pedersen Einar, and Dowd J. E.. 165 p., $6.50. The Johns Hopkins Press, Baltimore, Maryland 21218, 1967. JNCI: Journal of the National Cancer Institute, Volume 41, Issue 2, August 1968, Page 615, https://doi.org/10.1093/jnci/41.2.615 Published: 01 August 1968
Dietary diversity during early infancy increases gut microbial diversity and prevents egg allergy in high-risk infants
Authors: Jihyun Kim, Bo Ra Lee, Hye-In Jung, Su Kyung Kim, Mijeoung Kwon, Hyun Mi Kim, Minyoung Jung, Yechan Kyung, Byung Kim, Suk-Joo Choi, Soo-Young Oh, Sun-Young Baek, Seonwoo Kim, Kangmo Ahn
Journal: Journal of Allergy and Clinical Immunology (2022)