tbuckley/cabot-search huggingface dataset:
Magnetostrictive alloys: Promising materials for biomedical applications
Authors: Chengde Gao, Zihao Zeng, Shuping Peng, Cijun Shuai
Journal: Bioactive Materials (2021)

Magnetostrictive alloys have attracted increasing attention in biomedical applications because of the ability to generate reversible deformation in the presence of external magnetic fields. This review focuses on the advances in magnetostrictive alloys and their biomedical applications. The theories of magnetostriction are systematically summarized. The different types of magnetostrictive alloys and their preparation methods are also reviewed in detail. The magnetostrictive strains and phase compositions of typical magnetostrictive alloys, including iron based, rare-earth based and ferrite materials, are presented. Besides, a variety of approaches to preparing rods, blocks and films of magnetostriction materials, as well as the corresponding methods and setups for magnetostriction measurement, are summarized and discussed. Moreover, the interactions between magnetostrictive alloys and cells are analyzed and emphasis is placed on the transduction and transformation process of mechanochemical signals induced by magnetostriction. The latest applications of magnetostrictive alloys in remote microactuators, magnetic field sensors, wireless implantable devices and biodegradable implants are also reviewed. Furthermore, future research directions of magnetostrictive alloys are prospected with focus on their potential applications in remote cell actuation and bone repair.
長期免疫細胞追跡のための二重モードPET/近赤外蛍光ナノタグ【JST・京大機械翻訳】
Authors: Harmsen Stefan, Medine Emin Ilker, Moroz Maxim, Nurili Fuad, Lobo Jose, Dong Yiyu, Turkekul Mezruh, Pillarsetty Naga Vara Kishore, Ting Richard, Ponomarev Vladimir, Akin Oguz, Aras Omer
Journal: Biomaterials (2021)
Maximally selective single-cell target for circuit control in epilepsy models
Authors: Darian Hadjiabadi, Matthew Lovett-Barron, Ivan Georgiev Raikov, Fraser T. Sparks, Zhenrui Liao, Scott C. Baraban, Jure Leskovec, Attila Losonczy, Karl Deisseroth, Ivan Soltesz
Journal: Neuron (2021)
Rapid Screening of Targetable Kinase Gene Fusions in Acute Lymphoblastic Leukemia
Authors: Esperanza Such, Gayane Avetisyan, Iván Martín, Inés Gómez-Seguí, Francisca García, Eva Villamón, Alessandro Liquori, Francisco Mares, Marta Llop, Paula Amat, Mariam Ibañez, Eva Barragán, Mar Tormo, Guillermo Sanz, Carlos Solano, José Cervera, Blanca Navarro, Miguel A. Sanz
Journal: Blood (2017)
Unusual Variant of Breast Cancer Presenting With Pituitary Symptoms Detected on 68Ga-DOTATATE PET/CT
Authors: Indraja D. Dev, Ameya D. Puranik, Venkatesh Rangarajan, Nilendu C. Purandare, Archi Agrawal, Sneha Shah, Ayushi Sahay
Journal: Clinical Nuclear Medicine (2021)

Abstract Carcinoma of breast with neuroendocrine differentiation is an extremely rare entity, especially in male population. Although the “garden variety” of male breast cancers is often metastatic at presentation, with an aggressive course, there is hardly any literature about neuroendocrine variants. We report a case of a 57-year-old man who had pituitary symptoms, which on 68 Ga-DOTANOC PET/CT imaging turned out to be a metastatic lesion, with somatostatin expressing primary in breast and other sites, with histopathological confirmation of neuroendocrine differentiation in breast cancer.
Response to: ‘Correspondence on ‘Safety and efficacy of faecal microbiota transplantation for active peripheral psoriatic arthritis: an exploratory randomised placebo-controlled trial’’ by McGonagle<i>et al</i>
Authors: Maja Skov Kragsnaes, Jens Kjeldsen, Hans Christian Horn, Heidi Lausten Munk, Jens Kristian Pedersen, Søren Andreas Just, Palle Ahlquist, Jesper Rømhild Davidsen, Anna Christine Nilsson, Richard Röttger, Mogens Kruhøffer, Julian R Marchesi, Karsten Kristiansen, Robin Christensen, Torkell Ellingsen
Journal: Annals of the Rheumatic Diseases (2021)

We thank McGonagle et al 1 for their insightful comments on our manuscript on faecal microbiota transplantation (FMT) in active peripheral psoriatic arthritis (PsA), known as the FLORA trial.2 We agree that the clinical findings of this first double-blind, randomised, trial of FMT in immune-mediated arthritis warrant further investigation into the underlying biological mechanisms coupling gut composition, the intestinal barrier–microbiotal interaction, and systemic inflammation in PsA and related chronic inflammatory diseases. Indeed, evidence linking the composition of the gut microbiota and initiation/progression of immune-mediated disease is limited and is primarily derived from animal models.3 Suggested mechanisms encompass failure to induce immunological tolerance,4 which may direct the T cell repertoire towards a pro-inflammatory phenotype including Th17 differentiation and activation seen in PsA, loss of epithelial integrity5 and systemic translocation due to local inflammation and/or tissue damage that may enable trafficking of both activated immune cells and antigenic material to distant sites thereby creating perpetual systemic inflammatory stimuli6 by epitope spreading,7 bystander activation8 and/or molecular mimicry.9 …
A Geriatric Screening Tool (G8) Provides an Independent Prognostic Index for Azacitidine Treated Elderly MDS Patients
Authors: Angela Molga, Michelle Wall, Deepak Singhal, Rakchha Chhetri, Amilia Wee, Lucy Cussans, Nimit Singhal, Gillian Caughey, Luen Bik To, Peter Bardy, Sepehr Shakib, Ian D Lewis, Timothy To, Devendra K Hiwase
Journal: Blood (2017)
ISAR-REACT 5 Revisited Through the Lens of a Postrandomization Subgroup
Authors: Ajay J. Kirtane
Journal: JAMA Cardiology (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Separate criteria should be drawn up for questionnaire based epidemiological studies
Authors: B. Kaur, J. Taylor
Journal: BMJ (1996)

Editor,—Epidemiological surveys based on questionnaires are safe. They are non-invasive, do not involve a hazardous procedure or a controlled trial, and do not breach any medical confidentiality. They may also not involve NHS patients. Nevertheless, it is thought to be good practice to apply to research ethics committees before carrying out such a survey, though non-medical questionnaires are not subject to any scrutiny. We support the view that all questionnaire based studies should be reviewed but do not think that this should be under the current system. …
Sharing Technology and Vaccine Doses to Address Global Vaccine Inequity and End the COVID-19 Pandemic
Authors: Matthew M. Kavanagh, Lawrence O. Gostin, Madhavi Sunder
Journal: JAMA (2021)

This Viewpoint offers 3 strategies to address inequity in pandemic vaccine response: surge funding, increased funding, and an agreement to share technology and allow countries to waive intellectual property rights in global public health emergencies.
Bilateral Salpingo-Oophorectomy to Reduce Breast Cancer Risk in Women With Germline <i>BRCA1</i> or <i>BRCA2</i> Pathogenic Variants—Caution Needed
Authors: Ciara Conduit, Roger L. Milne, Kelly-Anne Phillips
Journal: JAMA Oncology (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Abstract 247: Rtf1 Controls Sarcomere Integrity and Cardiac Function
Authors: Fei Lu, Adam Langenbacher, Chen Gao, Vincent Ren, Yibin Wang, Jau-Nian Chen
Journal: Circulation Research (2016)

Sarcomere integrity must be continuously maintained in cardiomyocytes to ensure contractile function; however, the genetic programs controlling this process are not completely understood. We have previously shown that the RNA polymerase II associated protein Rtf1 directs cardiac progenitor cell formation during early cardiogenesis. Here we report that in mature cardiomyocytes, Rtf1 controls gene programs essential for the maintenance of sarcomere structure and cardiac function. Cardiomyocyte-specific ablation of Rtf1 in mice results in dilated cardiomyopathy characterized by thinning of the myocardial walls, dilation of the ventricular cavity and impaired left ventricle contractile function. Rtf1 knockdown in neonatal rat ventricular myocytes model results in the breakdown of sarcomeres and downregulation of myofibrillar gene programs accompanied by reduced abundance of monoubiquitinated H2BK120 and epigenetic marks associated with actively transcribed genes. In zebrafish embryos, mutation in Rtf1’s histone modification domain arrests cardiomyocyte differentiation and heart tube formation. Together these findings demonstrate that Rtf1 controls cardiomyocyte maturation, myofibril integrity and cardiac function by modulating cardiac epigenetic landscapes.
Next-Generation Sequencing Based Monitoring of Circulating-Tumor DNA in Untreated Peripheral T-Cell Lymphoma
Authors: Christopher Melani, Stefania Pittaluga, Lydia Yee, Andrea Lucas, Margaret Shovlin, Allison Jacob, Kenneth Chan, Marissa Vignali, Elaine S. Jaffe, Wyndham H. Wilson, Mark Roschewski
Journal: Blood (2017)
Deciphering Intratumoral Molecular Heterogeneity in Clear Cell Renal Cell Carcinoma with a Radiogenomics Platform
Authors: Durga Udayakumar, Ze Zhang, Yin Xi, Durgesh K. Dwivedi, Michael Fulkerson, Sydney Haldeman, Tiffani McKenzie, Qurratulain Yousuf, Allison Joyce, Asghar Hajibeigi, Hollis Notgrass, Alberto Diaz de Leon, Qing Yuan, Matthew A. Lewis, Ananth J. Madhuranthakam, Robert C. Sibley, Roy Elias, Junyu Guo, Alana Christie, Renée M. McKay, Jeffrey A. Cadeddu, Aditya Bagrodia, Vitaly Margulis, James Brugarolas, Tao Wang, Payal Kapur, Ivan Pedrosa
Journal: Clinical Cancer Research (2021)

Abstract Purpose: Intratumoral heterogeneity (ITH) challenges the molecular characterization of clear cell renal cell carcinoma (ccRCC) and is a confounding factor for therapy selection. Most approaches to evaluate ITH are limited by two-dimensional ex vivo tissue analyses. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can noninvasively assess the spatial landscape of entire tumors in their natural milieu. To assess the potential of DCE-MRI, we developed a vertically integrated radiogenomics colocalization approach for multi-region tissue acquisition and analyses. We investigated the potential of spatial imaging features to predict molecular subtypes using histopathologic and transcriptome correlatives. Experimental Design: We report the results of a prospective study of 49 patients with ccRCC who underwent DCE-MRI prior to nephrectomy. Surgical specimens were sectioned to match the MRI acquisition plane. RNA sequencing data from multi-region tumor sampling (80 samples) were correlated with percent enhancement on DCE-MRI in spatially colocalized regions of the tumor. Independently, we evaluated clinical applicability of our findings in 19 patients with metastatic RCC (39 metastases) treated with first-line antiangiogenic drugs or checkpoint inhibitors. Results: DCE-MRI identified tumor features associated with angiogenesis and inflammation, which differed within and across tumors, and likely contribute to the efficacy of antiangiogenic drugs and immunotherapies. Our vertically integrated analyses show that angiogenesis and inflammation frequently coexist and spatially anti-correlate in the same tumor. Furthermore, MRI contrast enhancement identifies phenotypes with better response to antiangiogenic therapy among patients with metastatic RCC. Conclusions: These findings have important implications for decision models based on biopsy samples and highlight the potential of more comprehensive imaging-based approaches.
Circulating MicroRNAs, the Next-Generation Serum Biomarkers in Testicular Germ Cell Tumours: A Systematic Review
Authors: Ricardo Leão, Maarten Albersen, Leendert H.J. Looijenga, Torgrim Tandstad, Christian Kollmannsberger, Matthew J. Murray, Stephane Culine, Nicholas Coleman, Gazanfer Belge, Robert J. Hamilton, Klaus-Peter Dieckmann
Journal: European Urology (2021)

Clinical management of testicular germ cell tumours (GCTs) is hampered by low sensitivity and specificity of the biomarkers currently in use. Circulating microRNAs (miRs) might offer the potential to address areas of unmet clinical need.To systematically evaluate the evidence for clinical applications of serum levels of miR302/367 and miR371-3 in adult testicular GCTs in terms of primary diagnosis, various clinical scenarios, and the costs of clinical implementation.We performed a critical review of PubMed/Medline, Embase and the Cochrane Library in January 2021 in accordance with Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement.Thirty-one manuscripts addressed miR performance and potential clinical use in testicular GCT. Of these, 23 evaluated the utility in primary diagnosis, seven in early-stage disease, and 13 in metastatic disease, and two addressed the costs of clinical implementation. Of the various miRs studied, miR-371a-3p appears the most useful and potentially the only one that needs to be assayed, with an area under the receiver operating characteristic curve >0.90, sensitivity of 89-96%, and specificity of >90% for both seminoma and nonseminoma, surpassing the classic serum tumour markers. The miRs studied to date are not elevated in cases with teratoma only. Levels of miR-371a-3p correlate with primary tumour mass, clinical stage, and International Germ Cell Cancer Collaborative Group risk groups. Serial measurements mirror treatment efficacy in all clinical stages.Circulating miRNA levels, particularly of miR-371a-3p, have potential for incorporation in clinical practice and may aid in clinical decision-making in various clinical scenarios in GCT.We analysed the current evidence on the usefulness of blood levels of molecules called microRNAs in the management of testicular tumours. The microRNA-371a-3p molecule has better sensitivity and specificity than the markers currently being measured. This new biomarker may soon have a place in clinical practice.
Abstract 312: Evaluating Novel Methods of Post Cardiac Arrest Outcome Assessment
Authors: Noah Krampe, Jon C Rittenberger, Clifton W Callaway, Jonathan Elmer
Journal: Circulation (2019)

Introduction: Recovery of cardiac arrest patients is dynamic over the first year. Loss to follow up is common and validated tools to assess long-term survival and function useful for observational research are lacking. We tested novel methods of long-term follow-up after resuscitation from cardiac arrest. Hypothesis: We hypothesized that post-acute encounters in our electronic health record (EHR) and internet-based searches would each allow determination of long-term vital status and function. Methods: We performed a retrospective study including consecutive patients treated after cardiac arrest at a single academic medical center from 2010 to 2018 who survived to hospital discharge. We used a structured data collection tool and three methods to assess post-discharge vital status and function (modified Rankin Scale score (mRS)): 1) a search of our health system’s EHR for post-discharge encounters; 2) an web-based search of local newspapers, ancestry sites, and other sources; and 3) a search of public social media postings attributed to the patient on Facebook, Twitter, and Instagram. Results: Overall, 900 patients met inclusion criteria. Of these, 544 (60%) were male and 643 (71%) arrested out-of-hospital. A minority, 257 patients, (29%) had good function (mRS 0-2) at hospital discharge. Overall, 862 patients (96%) had EHR data after their index hospitalization. Of these, 307 (36%) had a date of death confirmed in the EHR a median of 196 days [interquartile range (IQR) 59-703] days post-arrest. The remaining 555 patients were alive at their last known follow-up after a median of 830 [IQR 246 - 1661] days. Of these, 357 (64%) had documentation of function consistent with an mRS of 0-2. By contrast, we found 602 (67%) patients using web-based sources: 333 (37%) in local newspapers, 239 (27%) in ancestry sites, 319 (35%) on Facebook, 65 (7%) on Twitter, and 55 (6%) on Instagram. Web-based sources confirmed 25 additional deaths not identified in the EHR. Conclusions: This work supports use of novel methods of outcome assessment of patients’ vital and functional status after cardiac arrest. Further work will test these methods against reference standards.
Spatiotemporally dynamic therapy with shape-adaptive drug-gel for the improvement of tissue regeneration with ordered structure
Authors: Ya-nan Fu, Yongsan Li, Bo Deng, Yingjie Yu, Fang Liu, Lei Wang, Guang Chen, Lei Tao, Yen Wei, Xing Wang
Journal: Bioactive Materials (2021)

A spatiotemporally dynamic therapy (SDT) is proposed as a powerful therapeutic modality that provides spatially dynamic responses of drug-carriers for adapting to the wound microenvironment. Herein, dynamic chitosan-poly (ethylene glycol) (CP) Schiff-base linkages are employed to perform SDT by directly converting a liquid drug
Baseline characteristics of patients in the <scp>PARALLAX</scp> trial: insights into quality of life and exercise capacity in heart failure with preserved ejection fraction
Authors: Sanjiv J. Shah, Martin R. Cowie, Rolf Wachter, Peter Szecsödy, Victor Shi, Ghionul Ibram, Mo Hu, Ziqiang Zhao, Jianjian Gong, Burkert Pieske
Journal: European Journal of Heart Failure (2021)
Abstract 207: Electrically-induced Calcium Handling in Human Cardiac Progenitor Cells
Authors: Joshua T Maxwell, Mary B Wagner, Michael E Davis
Journal: Circulation Research (2016)

The discovery of a resident population of cardiac stem cells known as cardiac progenitor cells (CPCs) has raised the question of the mechanisms involved in regenerative properties of this niche of cells. The physiology of human CPCs is not well understood, and a thorough understanding of the Ca 2+ handling ability of these cells is crucial in order to fully realize their regenerative potential. Therefore, to characterize the mechanism of electrically-induced Ca 2+ handling in human CPCs, we have used cells loaded with fluo-4 calcium dye and imaged using confocal microscopy to determine the spatial and temporal profile of cytosolic Ca 2+ upon electrical stimulation. Upon activation of electrical stimulation, a large increase in cytosolic Ca 2+ was observed followed by oscillations of the cytosolic Ca 2+ . The electrically-induced Ca 2+ oscillations were found to be dependent on the activity of L-type Ca 2+ channels (LTCC) and the presence of extracellular Ca 2+ . Furthermore, these oscillations could be abolished by pre-treatment of the cells with the inositol 1,4,5-trisphosphate receptor (IP 3 R) antagonist 2-APB. High-speed confocal imaging of the electrically-induced Ca 2+ oscillations in hCPCs revealed that these cells oscillate in a Ca 2+ wave-like fashion with activity originating in isolated regions of the cell and propagating throughout the cytosol and nucleus. In conclusion, we propose that Ca 2+ -dependent regulatory mechanisms can be exploited to influence their differentiation potential leading to improved function in cardiac regenerative medicine.
Pulmonary Edema in Patients with Connective Tissue Disease-Associated Pulmonary Arterial Hypertension Receiving Pulmonary Vasodilator Therapies
Authors: Kinoshita Hideyuki, Kuwahara Koichiro, Yanagisawa Hiromu, Yoshifuji Hajime, Yamada Chinatsu, Kuwabara Yoshihiro, Nakagawa Yasuaki, Makiyama Takeru, Shizuta Satoshi, Ono Koh, Kimura Takeshi
Journal: Circulation (2016)
Sleep Patterns and Associated Clinical Correlates Amongst Ghanaian Individuals with Sickle Cell Disease
Authors: Samuel Wilson, Tulana Kpadenou, Fatimah Farooq, Eugenia Vicky Asare, Fitz Tavernier, Austin Novarra, Lewis Graham, Sophia Akatue, Bianca Oteng, Marianna Yamamoto, Sheri VanOmen, Ashya Smith, Duna Buttner, Gifty Dankwah, Haikel Haile, Rose Bamfo, Esther Kim, Ahmed Owda, Rebekah Urbonya, Onike Rodrigues, Catherine Idara Segbefia, Sudha Rao, Daniel Antwi, Edeghonghon Olayemi, Ivy Adwowa Efiefi Ekem, Fredericka Sey, Charles Antwi-Boasiako, Andrew D. Campbell
Journal: Blood (2017)
A review of existing strategies for designing long-acting parenteral formulations: Focus on underlying mechanisms, and future perspectives
Authors: Yujie Shi, An Lu, Xiangyu Wang, Zakia Belhadj, Jiancheng Wang, Qiang Zhang
Journal: Acta Pharmaceutica Sinica B (2021)

The need for long-term treatments of chronic diseases has motivated the widespread development of long-acting parenteral formulations (LAPFs) with the aim of improving drug pharmacokinetics and therapeutic efficacy. LAPFs have been proven to extend the half-life of therapeutics, as well as to improve patient adherence; consequently, this enhances the outcome of therapy positively. Over past decades, considerable progress has been made in designing effective LAPFs in both preclinical and clinical settings. Here we review the latest advances of LAPFs in preclinical and clinical stages, focusing on the strategies and underlying mechanisms for achieving long acting. Existing strategies are classified into manipulation of in vivo clearance and manipulation of drug release from delivery systems, respectively. And the current challenges and prospects of each strategy are discussed. In addition, we also briefly discuss the design principles of LAPFs and provide future perspectives of the rational design of more effective LAPFs for their further clinical translation.