tbuckley/cabot-search huggingface dataset:
Results of triple valve replacement in 91 patients: perioperative mortality and long-term follow-up.
Authors: B JGersh, H VSchaff, P JVatterott, G KDanielson, T AOrszulak, J MPiehler, F JPuga, J RPluth, D CMcGoon
Journal: Circulation (1985)

Between 1961 and 1984, 91 patients underwent simultaneous triple valve replacement at the Mayo Clinic. Of the 273 prosthetic valves used, 77% were Starr-Edwards. Perioperative (30 day) mortality was 24% to 27% between 1962 and 1974 and 7% between 1975 and 1983 (p = .17). In patients with NYHA class IV symptoms, perioperative mortality was 44%, and in those with milder symptoms, it was 8% (p less than .0001). The median follow-up was 7.5 years (range, 6 weeks to 20 years). Cumulative survival, which was calculated taking into consideration perioperative mortality, was 64% at 1 year, 55% at 5 years, 40% at 10 years, and 25% at 15 years. Multivariate analysis identified preoperative functional class and age as predictors of late survival. Among causes of late mortality were sudden death in 32.5%, congestive heart failure in 15%, thromboembolism in 12.5%, prosthetic valve dysfunction in 7.5%, and infective endocarditis in 5%. Late complications included systemic emboli in 42% (embolic rate, 12.3 events per 10...
Endoscopic Dilation of Post-Sleeve Gastrectomy Stenosis: Long-Term Efficacy and Safety Results
Authors: D Lorenzo, P Gkolfakis, A Lemmers, H Louis, V Huberty, D Blero, J Devière
Journal: Endoscopy (2021)

Aims Post-sleeve gastrectomy (SG) stenoses occur in about 5 % of cases. Hydrostatic dilation (HD) and pneumatic dilation (PD) have been proposed as treatments, but efficacy data remain scarce. The objectives of this study were to evaluate the safety and the initial and long-term efficacy of endoscopic balloon dilation for post-SG stenosis according to different mechanisms of post-SG stenosis.
Increased messenger RNA level of the inhibitory G protein alpha subunit Gi alpha-2 in human end-stage heart failure.
Authors: TEschenhagen, UMende, MNose, WSchmitz, HScholz, AHaverich, SHirt, VDöring, PKalmár, WHöppner
Journal: Circulation Research (1992)

In human heart failure the positive inotropic and cAMP-elevating effects of both beta-adrenoceptor agonists and phosphodiesterase inhibitors are diminished. This has been explained at least in part by an increase in the inhibitory signal-transducing G protein (Gi) and unchanged stimulatory G protein (Gs). In the present study we determined the mRNA expression pattern of the alpha subunits of Gi-1, Gi-2, Gi-3, and Gs in myocardial tissue samples of patients undergoing heart transplantation. Northern blot analysis of total RNA extracted from left ventricles with 32P-labeled cDNAs demonstrated expression of Gi alpha-2, Gi alpha-3, and Gs alpha mRNA. In contrast, Gi alpha-1 mRNA was not detectable. To investigate whether the increased ratio of Gi/Gs might be due to altered gene expression, we compared mRNA levels of Gi alpha-2, Gi alpha-3, and Gs alpha in left ventricular myocardium from failing hearts with idiopathic dilated cardiomyopathy (n = 8) and ischemic cardiomyopathy (n = 6) and from nonfailing heart...
Association between QT interval and coronary heart disease in middle-aged and elderly men. The Zutphen Study.
Authors: J MDekker, E GSchouten, PKlootwijk, JPool, DKromhout
Journal: Circulation (1994)

BACKGROUNDHeart-rate-adjusted QT-interval (QTc) is prognostic of sudden death in myocardial infarction patients. So far, population studies have yielded conflicting results on the predictive value of QTc for coronary heart disease morbidity and mortality. Therefore, we investigated this in a longitudinal study of middle-aged and elderly men.METHODS AND RESULTSFrom 1960 to 1985, 877 middle-aged men were followed and repeatedly examined in the Zutphen Study. In 1985 the remaining cohort was extended to 835 elderly men from the same birth cohort and followed until 1990. Men with prolonged QTc (420 ms1/2 or more) had a higher risk of myocardial infarction and coronary heart disease death relative to men with QTc less than 385 ms1/2. Age-adjusted coronary heart disease mortality rate ratios were 4.3 (95% confidence interval, 1.3 to 13.8) in middle-aged men and 3.3 (95% confidence interval, 1.0 to 11.6) in elderly men. These associations could not be attributed to prevalent heart disease and were independent of...
Effect of angiotensin-converting enzyme inhibitor (SQ 20881) on the plasma concentration of angiotensin I, angiotensin II, and arginine vasopressin in the dog during hemorrhagic shock.
Authors: J JMorton, P FSemple, I MLedingham, BStuart, M ATehrani, A RGarcia, GMcGarrity
Journal: Circulation Research (1977)

The effect of an angiotensin-converting enzyme inhibitor on the circulating levels of angiotensin I, angiotensin II, and arginine vasopressin was studied in dogs subjected to hypotensive hemorrhagic shock. In dogs subjected to hemorrhage but not given the inhibitor, angiotensin II rose 20-fold (from 69 to 1,343 pg/ml of plasma), whereas in dogs subjected to hemorrhage but pretreated with the inhibitor, angiotensin II rose only 2-fold (from 92 to 171 pg/ml of plasma). In the pretreated dogs angiotensin I rose 30-fold (from 108 to 3,232 pg/ml of plasma). There was no statistically significant difference between the vasopressin levels found in the untreated dogs and the levels found in dogs given the inhibitor (1,016 and 1,095 pg/ml of plasma). Of the 15 dogs in the untreated group, five died before retransfusion was completed (four of cardiac failure and one of cardiac arrhythmia); none of the 10 dogs in the inhibitor-treated group died. These observations suggest that the very high levels of angiotensin II...
To the Editor
Authors: Paweł Stróżecki, Gwidon Polak, Małgorzata Ukleja-Adamowicz, Bożena Pczkowska, Grażyna Zarzycka-Lindner, Wirginia Tomczak-Watras, Andrzej Adamowicz, Jacek Manitius
Journal: Kidney International (1999)
Prostaglandins and the control of blood flow in the canine myocardium.
Authors: T HHintze, GKaley
Journal: Circulation Research (1977)

A comprehensive study was undertaken to evaluate the effects of inhibition of prostaglandin (PG) synthesis on a variety of reactions in the coronary vascular bed of anesthetized, open-chest dogs. In 23 dogs an electromagnetic flow probe (EMFP) and hydraulic occluder were placed around either the left anterior descending or circumflex branches of the coronary artery and a needle was inserted distral to the EMFP. Injections into the coronary artery of arachidonic acid (AA), bradykinin, adenosine, angiotensin, and PGE2 were given before and after inhibition of PG synthesis by indomethacin (IND) or meclofenamate (MF). The effects of the inhibitors on reactive hyperemia resulting from 5-, 10-, 15-, and 20-second occlusions and the dilation resulting from 90-second exposure to 8% O2 were also examined. In each experiment, inhibition of PG synthesis was ascertained by the elimination of vasodilation to AA. After administration of IND or MF, while baseline coronary blood flow was slightly reduced, the total incre...
Vaccination with prefusion-stabilized respiratory syncytial virus fusion protein induces genetically and antigenically diverse antibody responses
Authors: Maryam Mukhamedova, Daniel Wrapp, Chen-Hsiang Shen, Morgan S.A. Gilman, Tracy J. Ruckwardt, Chaim A. Schramm, Larissa Ault, Lauren Chang, Alexandrine Derrien-Colemyn, Sarah A.M. Lucas, Amy Ransier, Samuel Darko, Emily Phung, Lingshu Wang, Yi Zhang, Scott A. Rush, Bharat Madan, Guillaume B.E. Stewart-Jones, Pamela J. Costner, LaSonji A. Holman, Somia P. Hickman, Nina M. Berkowitz, Nicole A. Doria-Rose, Kaitlyn M. Morabito, Brandon J. DeKosky, Martin R. Gaudinski, Grace L. Chen, Michelle C. Crank, John Misasi, Nancy J. Sullivan, Daniel C. Douek, Peter D. Kwong, Barney S. Graham, Jason S. McLellan, John R. Mascola
Journal: Immunity (2021)
Direct myocardial and coronary effects of enalaprilat in patients with dilated cardiomyopathy: assessment by a bilateral intracoronary infusion technique.
Authors: J MFoult, OTavolaro, IAntony, ANitenberg
Journal: Circulation (1988)

Angiotensin II elicits contractile responses in the coronary arteries and myocardial tissue, which suggests that blockade of the renin-angiotensin system by specific agents should lead to both coronary vasodilation and an alteration of left ventricular inotropism. The present work was designed to delineate--independently from its systemic effects--the intrinsic actions of an angiotensin converting-enzyme inhibitor on the coronary circulation and left ventricular function. To minimize peripheral effects, a bilateral intracoronary infusion of enalaprilat (0.05 mg.min-1, 1 ml.min-1 in each coronary artery) was performed in 16 patients with dilated cardiomyopathy. All patients had normal coronary arteriograms. In 12 patients (group I) the intracoronary infusion of enalaprilat resulted in minimal peripheral changes, with a 5% reduction in the mean aortic pressure (p less than .05) and no significant alteration in indexes of preload, i.e., left ventricular end-diastolic pressure and volume, or of afterload, i.e...
Evaluation Of A New Lifting Gel For Endoscopic Submucosal Dissection In An Ex-Vivo Bovine Colon Model: A French Prospective Randomized Study
Authors: T Lambin, J Rivory, T Ponchon, I Bardin, M Fabritius, P Bonniaud, M Pioche
Journal: Endoscopy (2021)

Aims During endoscopic submucosal dissection (ESD), a lifting solution is injected between the muscularis mucosae and the submucosal layer to create a cushion protecting from the risk of perforation and bleeding. Hydroxyethyl starch (HES) is widely used because it provides a long duration of submucosal lifting with a safe profile. Q-gel is a new lifting solution designed by 3-D matrix (Japan) composed of extracellular matrix peptide. The aim of our study was to evaluate the efficacy of the Q-Gel in colonic ESD compared to HES.
Thymectomy for Myasthenia Gravis
Authors: Y SHIBOTA, R MOTOKI, R ONODERA, M TSUKAMOTO, T MATSUSHIRO, H SAKAI, T OIKAWA
Journal: New England Journal of Medicine (1965)

Enlargement of the thymus frequently occurs in myasthenie patients, and thymectomy has been followed by clinical improvement, particularly for certain classes of patients. However, there is no demonstrated causal relationship between thymic enlargement and production of faulty neuromuscular transmission. Results of immunological research conducted over the past few years indicate that very early in life the thymus is responsible for the establishment of certain immunological defenses of the body. If, as proposed in 1960,<sup>1</sup>myasthenia gravis is an autoimmune disease, perhaps there is at least some basis for connecting the thymic enlargement seen in myasthenia with certain immunological disturbances which occur in this disease. It is possible that thymectomy might break a chain of influences which leads to the production of autoimmune responses manifest in myasthenia gravis. An investigation observing the influence of thymectomy on certain immunological derangements which occur in myasthenia gravis is published in the<i>July Archives</i>
Intracranial Relationship Between Arterioles and Venules Size
Authors: Pasquale De Bonis, Paolo Zamboni
Journal: JAMA Neurology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Intrarenal site of action of calcium on renin secretion in dogs.
Authors: B EWatkins, J ODavis, T ELohmeier, R HFreeman
Journal: Circulation Research (1976)

We studied the effects of intrarenal calcium infusion on renin secretion in sodium-depleted dogs in an attempt to elucidate the major site of calcium-induced inhibition of renin release. Both calcium chloride and calcium gluconate reduced renal blood flow and renin secretion while renal perfusion pressure was unchanged. These data indicate that calcium inhibition of renin secretion did not occur primarily at the renal vascular receptor; decreased renal blood flow is usually associated with increased renin secretion. Calcium chloride infusion increased urinary chloride excretion without affecting sodium excretion, and calcium gluconate failed to increase either sodium or chloride excretion. Also, the filtered loads of sodium and chloride were unchanged during the calcium infusions. These results give no indication that calcium inhibited renin secretion by increasing the sodium or chloride load at the macula densa. The effects of intrarenal calcium infusion on renin release were also assessed in dogs with a...
Neurostimulation for Parkinson's Disease with Early Motor Complications
Authors: Francisco Carmona-Torre, Diego Martinez-Urbistondo, Jose L Del Pozo
Journal: New England Journal of Medicine (2013)

Subthalamic stimulation reduces motor disability and improves quality of life in patients with advanced Parkinson's disease who have severe levodopa-induced motor complications.We hypothesized that neurostimulation would be beneficial at an earlier stage of Parkinson's disease. CONCLUSIONSSubthalamic stimulation was superior to medical therapy in patients with Parkinson's disease and early motor complications.(Funded by the German Ministry of Research and others; EARLYSTIM ClinicalTrials.govnumber, NCT00354133.)
Responses of normal children and young adults to controlled bicycle exercise.
Authors: F WJames, SKaplan, C JGlueck, J YTsay, M JKnight, C JSarwar
Journal: Circulation (1980)

Exercise responses were obtained from 149 children and young adults (average age 14.5 years) and divided by sex and body surface area (BSA): children with BSA less than 1 m2; children with BSA 1--1.19 m2; males with BSA greater than or equal to 1.2 m2; and females with BSA greater than or equal to 1.2 m2. Total work, mean and maximal power outputs were more affected by body size (height) than age in children with BSA less than 1 m2 and in males and females with BSA greater than or equal to 1.2 m2. Mean systolic pressure increased up to 64% above the preexercise supine value at peak effort, with the level of mean maximal systolic pressure having a positive relationship with body size (height), power output and preexercise sitting systolic pressure in all subgroups except children with BSA 1--1.19 m2. Mean diastolic pressure increased up to 24% above the preexercise supine value at peak effort. ST-segment depression of 1--2 mm was recorded in 12.1% (18 of 149) of the population at peak exercise. These chang...
Cartilage Substitutes: Graphene Oxide‐Doped Gellan Gum–PEGDA Bilayered Hydrogel Mimicking the Mechanical and Lubrication Properties of Articular Cartilage (Adv. Healthcare Mater. 7/2021)
Authors: Diego Trucco, Lorenzo Vannozzi, Eti Teblum, Madina Telkhozhayeva, Gilbert Daniel Nessim, Saverio Affatato, Hind Al‐Haddad, Gina Lisignoli, Leonardo Ricotti
Journal: Advanced Healthcare Materials (2021)
Silibinin enhances UVB-induced apoptosis in human epidermoid carcinoma A431 cells via proapoptotic mitochondrial proteins and caspases activation
Authors: Sivanandhan Dhanalakshmi, Sarumathi Mohan, Rana P. Singh, G. U. Mallikarjuna, Rajesh Agarwal
Journal: Cancer Research (2004)

1373  Several recent studies by us have shown that silymarin (a mixture of different flavanolignans with silibinin being a major active principle) as well as pure agent silibinin exert strong chemopreventive efficacy against both ultraviolet B (UVB) radiation and chemical carcinogen-induced tumorigenesis in mouse skin models. The molecular mechanisms underlying silibinin protective efficacy, however, are not completely known. In the present study, we examined the effect of silibinin pre-treatment on UVB-caused apoptosis in human epidermoid carcinoma A431 cells. Treatment of cells with silibinin resulted in a further increase in UVB-induced apoptosis as observed by flow cytometry analysis of annexin V-propidium iodide-stained apoptotic cells. Irradiation of A431 cells with 15 and 30 mJ/cm2 UVB doses resulted in 42.4±3.4 and 52.8±5.06% apoptosis, whereas pre-treatment with silibinin (100 μM) for 12 h significantly increased apoptotic cell population to 69.6±2.8 and 77.5±6.25% (P
A human homolog of Notum, overexpressed in hepatocellular carcinoma, is transcriptionally regulated by beta-catenin/TCF
Authors: Akira Watanabe, Yuichi Torisu, Aya Nonaka, Yutaka Midorikawa, Takahiro Shimamura, Hiroko Iwanari, Atsushi Niida, Tetsu Akiyama, Tatsuhiko Kodama, Masatoshi Makuuchi, Mikio Zeniya, Hiroyuki Aburatani
Journal: Cancer Research (2007)

LB-54  The Drosophila Notum gene, which is regulated by the Wingless pathway, encodes a secreted hydrolase that modifies heparan sulfate proteoglycans. Our comparative analysis of gene expression in primary human hepatocellular carcinomas (HCCs) and normal organs, including liver, showed that the human ortholog of the Drosophila Notum was markedly overexpressed in a subset of HCCs. We investigated the regulation of NOTUM expression in HCC, focusing on the status of the Wnt pathway because Drosophila Notum is regulated by Armadillo, an ortholog of human beta-catenin. Intracellular beta-catenin was observed in 10 of 40 HCCs by immunohistochemistry (cytoplasmic staining in 1 cases, nuclear staining in 9 case), while membrane-bound beta-catenin was observed in the remaining 30 HCCs. Sequence analysis of CTNNB1 exon 3 revealed 11 HCC cases with somatic missense mutations. Ten of the 11 mutant cases exhibited intracellular beta-catenin staining (nuclear or cytoplasmic), while one mutant case exhibited membrane staining. Overexpression of NOTUM was associated with intracellular beta-catenin localization (10 of 10 cases), but was observed in only 2 of 30 HCCs with membrane staining (6.7%; P
A controlled clinical trial to assess the effect of a calcium channel blocker on the progression of coronary atherosclerosis.
Authors: DWaters, JLespérance, MFrancetich, DCausey, PThéroux, Y KChiang, GHudon, LLemarbre, MReitman, MJoyal
Journal: Circulation (1990)

To determine whether calcium channel blockers influence the progression of coronary atherosclerosis, 383 patients age 65 years or less with 5-75% stenoses in at least four coronary artery segments were selected at random within 1 month of coronary arteriography to participate in double-blind therapy with a placebo or nicardipine 30 mg three times daily. Coronary events (5 deaths, 22 myocardial infarctions, and 28 unstable anginas) occurred in 28 of 192 nicardipine patients and 23 of 191 placebo patients (p = NS). At 24 months coronary arteriography was repeated in 335 patients. Progression, defined as a 10% or more worsening in diameter stenosis, measured quantitatively, was found in 147 of 1,153 lesions (12.7%) in 168 nicardipine patients and in 170 of 1,170 lesions (14.5%) in 167 placebo patients (p = NS). Ninety-two nicardipine patients (55%) and 95 placebo patients (57%) had progression at one or more sites (p = NS). Regression, that is, an improvement by 10% or more in diameter stenosis, was seen in ...
Influence of dietary fat on the pharmacodynamics of propafenone in isolated, perfused rabbit hearts.
Authors: A MGillis, RKeashly, P AWatson, H JMathison, H GParsons
Journal: Circulation (1992)

BACKGROUNDThe fatty acid composition of the phospholipids in sarcolemma may significantly influence cell membrane functions. We evaluated the effects of dietary fat on the pharmacodynamics of the antiarrhythmic drug propafenone in isolated, perfused rabbit hearts.METHODS AND RESULTSThree groups of weanling rabbits (n = 9 each group) were fed diets of 10% wt/wt lard, fish oil, or safflower oil for 40 days. Differences in electrophysiological variables were assessed at baseline and during propafenone perfusion. Myocardial concentration-effect relations were determined by plotting electrophysiological effects versus coronary sinus propafenone concentrations. The linoleic acid content of isolated sarcolemma was higher in the safflower group (33.4 +/- 11.4%) than in the lard (13.4 +/- 2.3%, p less than 0.01) and fish oil (8.5 +/- 1.4%, p less than 0.01) groups, whereas the omega-3 fatty acid content was higher in the fish oil group (p less than 0.01). During propafenone perfusion, greater changes in ventricula...
Chronic lability of the arterial blood pressure produced by electrolytic lesions of the nucleus tractus solitarii in the rat.
Authors: R ABuchholz, M ANathan
Journal: Circulation Research (1984)

The purpose of this study was to assess the chronic effects of lesions of the nucleus tractus solitarii on the cardiovascular activity of rats. Arterial pressure and heart rate were recorded in conscious, unrestrained rats 7-216 days following placement of electrolytic lesions in the nucleus tractus solitarii. To assess the impact of environmental stimuli on the mean level and lability of the mean arterial pressure, cardiovascular activity was recorded under conditions of controlled and uncontrolled environmental stimulation. Nucleus tractus solitarii lesions abolished the reflex bradycardia to a phenylephrine-induced elevation in arterial pressure. A marked increase in the lability of the mean arterial pressure was produced with nucleus tractus solitarii lesions. The standard deviation of the mean arterial pressure, an index of lability, was 380% greater in rats with lesions than in control rats. The average mean arterial pressure, heart rate and heart rate variability were not significantly different be...
Letter by Niccoli et al Regarding Article, “Presence of Older Thrombus Is an Independent Predictor of Long-Term Mortality in Patients With ST-Elevation Myocardial Infarction Treated With Thrombus Aspiration During Primary Percutaneous Coronary Intervention”
Authors: Giampaolo Niccoli, Nicola Cosentino, Filippo Crea
Journal: Circulation (2009)
Effects of resting vagal tone on accessory atrioventricular connections.
Authors: FMorady, A HKadish, SSchmaltz, SRosenheck, JSummitt
Journal: Circulation (1990)

The purpose of this study was to determine the effects of resting vagal tone on accessory atrioventricular (AV) connections. Atropine (0.04 mg/kg) was administered to 13 patients with the Wolff-Parkinson-White syndrome and was found to have the following effects on the accessory AV connection: the anterograde block cycle length shortened from 305 +/- 51 to 279 +/- 54 msec (mean +/- SD; p less than 0.001); the retrograde block cycle length shortened from 288 +/- 57 to 251 +/- 50 msec (p less than 0.001); and the effective refractory period measured at a basic drive cycle length of 400 msec shortened from 295 +/- 45 to 265 +/- 47 msec in the anterograde direction (p less than 0.001) and from 283 +/- 18 to 261 +/- 12 msec in the retrograde direction (p less than 0.01). During atrial fibrillation, the mean ventricular cycle length decreased from 434 +/- 88 to 352 +/- 56 msec (p less than 0.001), and the shortest preexcited RR interval decreased from 302 +/- 56 to 256 +/- 43 msec (p less than 0.01). In another...