tbuckley/cabot-search huggingface dataset:
Significance of a negative exercise thallium test in the presence of a critical residual stenosis after thrombolysis for acute myocardial infarction.
Authors: J MSutton, E JTopol
Journal: Circulation (1991)

BACKGROUNDAfter thrombolytic therapy for acute myocardial infarction, increasing emphasis is placed on early submaximal exercise testing, with further intervention advocated only for demonstrable ischemia. Although significant residual coronary artery lesions after successful thrombolysis are common, many patients paradoxically have no corresponding provokable ischemia.METHODS AND RESULTSThe relation between significant postthrombolytic residual coronary artery disease and a negative early, submaximal exercise thallium-201 tomogram was studied among 101 consecutive patients with uncomplicated myocardial infarction and at least 70% residual stenosis of the infarct artery. A negative test occurred in 49 (48.5%) patients with a mean 88% residual infarct artery stenosis. Further characteristics of the group were as follows: mean time to treatment was 3.1 hours; mean age was 54 +/- 10 years; 80% were male; 47% had anterior infarction; 39% had multivessel disease; mean left ventricular ejection fraction was 53 ...
Impact of Previously Unrecognized HLA Mismatches Using Ultrahigh Resolution Typing in Unrelated Donor Hematopoietic Cell Transplantation
Authors: Neema P. Mayor, Tao Wang, Stephanie J. Lee, Michelle Kuxhausen, Cynthia Vierra-Green, Dominic J. Barker, Jeffrey Auletta, Vijaya R. Bhatt, Shahinaz M. Gadalla, Loren Gragert, Yoshihiro Inamoto, Gerald P. Morris, Sophie Paczesny, Ran Reshef, Olle Ringdén, Bronwen E. Shaw, Peter Shaw, Stephen R. Spellman, Steven G. E. Marsh
Journal: Journal of Clinical Oncology (2021)

Ultrahigh resolution (UHR) HLA matching is reported to result in better outcomes following unrelated donor hematopoietic cell transplantation, improving survival and reducing post-transplant complications. However, most studies included relatively small numbers of patients. Here we report the findings from a large, multicenter validation study.
Wall shear stress temporal gradient and anastomotic intimal hyperplasia.
Authors: MOjha
Journal: Circulation Research (1994)

Unusual wall shear stress patterns on the bed of end-to-side arterial anastomoses appear to be the primary factor in the development of intimal hyperplasia that often leads to arterial bypass graft failure. In this in vitro study using the photochromic tracer technique, the shear stress variation on the bed of a 30 degrees anastomosis was examined before and after the development of hyperplasia. With the disease-free model, a rapid downstream shift in the stagnation point was seen on the bed during the systolic phase of the flow cycle, which led to sharp temporal changes in the shear stress from positive to negative values, ie, rapid changes in the direction of the shearing force. The resulting negative temporal gradients were roughly eight times larger than those seen in a straight tube, and it is suggested that this may lead to endothelial deformation or injury and eventually to intimal thickening. With the diseased model, the simulated tissue overgrowth on the bed appeared to act as a flow divider that...
Use of Procalcitonin Assays to Predict Serious Bacterial Infection in Young Febrile Infants
Authors: James W. Antoon, Michael J. Steiner
Journal: JAMA Pediatrics (2016)

To the Editor We commend Milcent et al1 on their prospective study on the use of procalcitonin in the diagnosis of serious bacterial infections in infants. We believe there are 3 issues that limit applicability of the study as presented.
Adult Serum in Measles
Authors: K. le Fleming
Journal: BMJ (1937)

During movement planning, brain activity within parietofrontal networks encodes information about upcoming actions that can be driven either externally (e.g., by a sensory cue) or internally (i.e., by a choice/decision). Here we used multivariate pattern analysis (MVPA) of fMRI data to distinguish between areas that represent (1) abstract movement plans that generalize across the way in which these were driven, (2) internally driven movement plans, or (3) externally driven movement plans. In a delayed-movement paradigm, human volunteers were asked to plan and execute three types of nonvisually guided right-handed reaching movements toward a central target object: using a precision grip, a power grip, or touching the object without hand preshaping. On separate blocks of trials, movements were either instructed via color cues (Instructed condition), or chosen by the participant (Free-Choice condition). Using ROI-based and whole-brain searchlight-based MVPA, we found abstract representations of planned movements that generalize across the way these movements are selected (internally vs externally driven) in parietal cortex, dorsal premotor cortex, and primary motor cortex contralateral to the acting hand. In addition, we revealed representations specific for internally driven movement plans in contralateral ventral premotor cortex, dorsolateral prefrontal cortex, supramarginal gyrus, and in ipsilateral posterior parietotemporal regions, suggesting that these regions are recruited during movement selection. Finally, we observed representations of externally driven movement plans in bilateral supplementary motor cortex and a similar trend in presupplementary motor cortex, suggesting a role in stimulus–response mapping. <b>SIGNIFICANCE STATEMENT</b> The way the human brain prepares the body for action constitutes an essential part of our ability to interact with our environment. Previous studies demonstrated that patterns of neuronal activity encode upcoming movements. Here we used multivariate pattern analysis of human fMRI data to distinguish between brain regions containing movement plans for instructed (externally driven) movements, areas involved in movement selection (internally driven), and areas containing abstract movement plans that are invariant to the way these were generated (i.e., that generalize across externally and internally driven movement plans). Our findings extend our understanding of the neural basis of movement planning and have the potential to contribute to the development of brain-controlled neural prosthetic devices.
The anatomical substrates of wolff-parkinson-white syndrome. A clinicopathologic correlation in seven patients.
Authors: A EBecker, R HAnderson, DDurrer, H JWellens
Journal: Circulation (1978)

Clinicopathological correlations were made on the hearts from seven patients known to have exhibited electrocardiographic evidence of the Wolff-Parkinson-White syndrome. In each case, clinical and pathological investigations were conducted independently, neither group of investigators having knowledge of the other's results. In all seven hearts, the entire atrioventricular junctions were serially sectioned. Accessory atrioventricular connections were predicted in all seven cases following electrocardiographic investigation. Connections were identified histopathologically in four hearts in the predicted site. In another case two connections were identified, one being considered responsible for the pre-excitation. In the sixth case a right lateral connection was anticipated, but only accessory nodo-ventricular fibers were identified following histopathologic studies. In the final case, a posterior septal connection was predicted but the entire septum had fibrosed following previous operation. These findings...
Role of alpha 2-adrenoceptors in normal and atherosclerotic human coronary circulation.
Authors: CIndolfi, FPiscione, BVillari, ERussolillo, VRendina, PGolino, MCondorelli, MChiariello
Journal: Circulation (1992)

BACKGROUNDExperimental studies on the effects of alpha 2-adrenoceptors on regional coronary blood flow in normal and ischemic myocardium are highly controversial. A beneficial effect on regional ischemic myocardium has been demonstrated in different animal preparations with either alpha 2-adrenoceptor blockade or stimulation. Animal studies also demonstrated that postsynaptic alpha 2-adrenoceptors mediate vasoconstriction in coronary and femoral vascular beds. The aims of the study were 1) to investigate the effects of regional alpha 2-adrenoceptor stimulation on regional coronary blood flow in subjects with angiographically normal coronary arteries, 2) to assess the effect of alpha 2-adrenoceptor blockade on coronary circulation in control subjects, and 3) to examine the influence of atherosclerosis on coronary blood flow response to alpha 2-adrenoceptor blockade.METHODS AND RESULTSThe effect of regional administration of BHT 933 (a selective alpha 2-adrenoceptor agonist) was studied in eight subjects wi...
Provisional Mortality Data — United States, 2020
Authors: Farida B. Ahmad, Jodi A. Cisewski, Arialdi Miniño, Robert N. Anderson
Journal: MMWR Morbidity and Mortality Weekly Report (2021)

CDC's National Vital Statistics System (NVSS) collects and reports annual mortality statistics using data from U.S. death certificates. Because of the time needed to investigate certain causes of death and to process and review data, final annual mortality data for a given year are typically released 11 months after the end of the calendar year. Daily totals reported by CDC COVID-19 case surveillance are timely but can underestimate numbers of deaths because of incomplete or delayed reporting. As a result of improvements in timeliness and the pressing need for updated, quality data during the global COVID-19 pandemic, NVSS expanded provisional data releases to produce near real-time U.S. mortality data.* This report presents an overview of provisional U.S. mortality data for 2020, including the first ranking of leading causes of death. In 2020, approximately 3,358,814 deaths† occurred in the United States. From 2019 to 2020, the estimated age-adjusted death rate increased by 15.9%, from 715.2 to 828.7 deaths per 100,000 population. COVID-19 was reported as the underlying cause of death or a contributing cause of death for an estimated 377,883 (11.3%) of those deaths (91.5 deaths per 100,000). The highest age-adjusted death rates by age, race/ethnicity, and sex occurred among adults aged ≥85 years, non-Hispanic Black or African American (Black) and non-Hispanic American Indian or Alaska Native (AI/AN) persons, and males. COVID-19 death rates were highest among adults aged ≥85 years, AI/AN and Hispanic persons, and males. COVID-19 was the third leading cause of death in 2020, after heart disease and cancer. Provisional death estimates provide an early indication of shifts in mortality trends and can guide public health policies and interventions aimed at reducing numbers of deaths that are directly or indirectly associated with the COVID-19 pandemic.
Ventricular mechanoreflex and chemoreflex alterations in chronic heart failure.
Authors: MBrändle, WWang, I HZucker
Journal: Circulation Research (1994)

Cardiac and arterial baroreflex control of the circulation is abnormal in both human and experimental heart failure. Ventricular vagal afferents mediate mechanical and chemical reflexes, which result in bradycardia and hypotension. The aim of the present study was to evaluate the changes that occur in ventricular mechanoreflexes and chemoreflexes in a conscious canine model of chronic heart failure. Dogs were instrumented for the measurement of left ventricular pressure, left atrial pressure, arterial pressure, and heart rate. Vascular occluders were placed on the ascending thoracic aorta, on the descending thoracic aorta, and on the thoracic inferior vena cava. A chronic left circumflex coronary artery catheter was also implanted. Finally, a pacing lead was secured to the left ventricular free wall. After recovery from surgery (10 to 14 days), the dogs were subjected to complete arterial baroreceptor denervation. The responses to vascular occlusions and intracoronary administration of prostacyclin (PGI2)...
A Preliminary Study of Long-Term Treatment with Interferon Gamma-1b and Low-Dose Prednisolone in Patients with Idiopathic Pulmonary Fibrosis
Authors: Raymond Roos
Journal: New England Journal of Medicine (2000)

The New Eng land Jour nal of Medicine ical presentations, describes other diseases that masquerade as amyotrophic lateral sclerosis, provides illustrative case reports, gives detailed examples of neurophysiologic and neuropathological findings, and provides mortality data.Also helpful is the information on treatment, which is accompanied by specific dosages and descriptions of personal experiences with the use of particular drugs.The authors manage to deal with issues in a fair and balanced way and provide their perspective on controversial issues, when appropriate.This is a book for neurologists and medical students, especially those with a special interest in amyotrophic lateral sclerosis.Nonclinical neuroscientists who want to learn more about the disease will also find it educational.Although the book includes a discussion of basic-research topics relevant to amyotrophic lateral sclerosis, it emphasizes clinical research, particularly neuroimaging, neurophysiology, and trials of therapy rather than more fundamental neuroscientific issues.For example, there is no description of the neurobiology of the motor neuron and only a relatively brief description of SOD-1 (with no description of the biochemical, molecular biologic, or structural features of the enzyme), whereas more than 40 pages -the longest chapter in the book -cover clinical neurophysiology.The book is relatively up to date, although more recent developments in this rapidly changing field are unavoidably omitted; for example, breakthroughs in the understanding of spinal muscular atrophy are not discussed.In addition, one could take issue with the inadequacy of the citations for a few topics; for instance, no references are cited in the discussion of the "wasted mouse" model.However, these are minor criticisms that do not detract from the success of this treatise on a disease that has never ceased to fascinate, inspire, and challenge.
EUS Guided Drainage of Intra Abdominal Diverticular Abscess. A Case Series
Authors: F Cereatti, A Spota, G Donatelli
Journal: Endoscopy (2021)

Aims Diverticular disease is widespread worldwide. Mainstay approach is non operative treatment with bowel rest and broad-spectrum intravenous antibiotics. However, extra-colic abscess larger than 4 cm may require percutaneous trans-abdominal drainage. We report a single center case series of patients underwent to trans-luminal endoscopic ultrasound (EUS) guided drainage of pelvic abscess in diverticular disease with temporary placement of lumen apposing metal stent (LAMS).
Preferential sensitivity of the left canine purkinje system to cardiac glycosides.
Authors: JReiser, G JAnderson
Journal: Circulation Research (1981)

Previous studies have shown that the toxic effects of cardiac glycosides are not manifested uniformly throughout the myocardium. The purpose of our study was to determine whether cardiac glycosides exert different effects on the right vs. left peripheral Purkinje systems and to ascertain mechanisms involved. Control in vitro measurements of paired right and left canine Purkinje fibers showed higher spontaneous rates in left (24.2 +/- 1.75 beats/min) than in right (11.6 +/- 1.55 beats/min, P less than 0.01, n = 81) Purkinje fiber bundles. Following overdrive stimulation, left Purkinje fiber bundles also showed earlier escape beats. After ouabain exposure (2 X 10-7 M), left Purkinje fiber bundles showed earlier signs of toxicity in 20 of 28 experiments, as determined by changes in the maximum diastolic potential, the degree of diastolic depolarization, spontaneous escape intervals, and the magnitude of delayed after-depolarizations. The enhanced sensitivity of left Purkinje fiber bundles was independent of ...
Transmural right ventricular blood flow during acute pulmonary artery hypertension in the sedated dog. Evidence for subendocardial ischemia despite residual vasodilator reserve.
Authors: F LGold, R JBache
Journal: Circulation Research (1982)

Right ventricular failure during acute pressure overload has been attributed to ischemia which occurs when maximal coronary vasodilation is achieved so that further increases in myocardial blood flow cannot occur. To test the hypothesis that coronary vasodilator reserve is exhausted during acute right ventricular pressure overload, right and left ventricular myocardial blood flow was measured in 14 awake dogs during progressive pulmonary artery occlusion; coronary vasodilator reserve was tested by infusion of adenosine (4 microM/kg per min) before and during pulmonary artery occlusion. Right ventricular myocardial blood flow rose from 0.77 +/- 0.09 ml/min per g (mean +/- SEM) during control conditions to 1.69 +/- 0.27 ml/min per g during moderate pulmonary artery occlusion (P less than 0.01). With further pulmonary artery occlusion to cause increased right ventricular end-diastolic pressure and decreased aortic pressure, a selective decrease in myocardial blood flow to the right ventricular subendocardium...
"A Pretty Ghastly, Awful Picture"
Journal: BMJ (1961)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following “A Pretty Ghastly, Awful Picture” Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
The relationship of patient selection to prognosis following aortocoronary bypass.
Authors: M JConley, A SWechsler, R WAnderson, H NOldham, D CSabiston, R ARosati
Journal: Circulation (1977)

Operative mortality for the first 787 patients who underwent aortocoronary bypass at Duke University Medical Center was 9.7%. Within 699 patients who underwent elective bypass only, operative mortality was 8.8% before January 1, 1972, and 5.4% subsequently. This apparent variation in operative mortality over time was largely a consequence of changing patterns of patient selection, i.e., a two- to three-fold decrease in the prevalence of ventricular dysfunction. Since January 1, 1972, operative mortality for 444 patients with mild or no heart failure who underwent elective bypass only was 5.0%. The 55 patients with left main disease had 12.7% operative mortality. In the 192 patients without left main disease who had one- or two-vessel disease, operative mortality was 1.0%, whereas, 197 patients with three-vessel disease had a 6.6% operative mortality. The 103 patients with three-vessel disease less than 50 years of age underwent operation with a 2.9% mortality. Although these results demonstrate that selec...
Neuronal sodium homoeostatis and axoplasmic amine concentration determine calcium-independent noradrenaline release in normoxic and ischemic rat heart.
Authors: ASchömig, TKurz, GRichardt, ESchömig
Journal: Circulation Research (1988)

Calcium-independent noradrenaline release was studied in the isolated perfused rat heart under conditions of normoxia, cyanide intoxication, and ischemia. The release of endogenous noradrenaline and dihydroxyphenylglycol were determined by high-performance liquid chromatography. The release of dihydroxyphenylglycol, the main neuronal noradrenaline metabolite, was used as an indicator of the free axoplasmic amine concentration. When storage function of neuronal vesicles was disturbed by Ro 4-1284 or trimethyltin, high dihydroxyphenylglycol release was observed without concomitant overflow of noradrenaline. If, however, these agents were combined with inhibition of Na+K+-ATPase or with veratridine-induced entry of sodium into the neuron, both dihydroxyphenylglycol and noradrenaline were released. Noradrenaline release was independent of extracellular calcium and was suppressed by blockade of neuronal catecholamine uptake (uptake1), indicating nonexocytotic noradrenaline liberation from the sympathetic nerve...
Mechanical interactions between four heart chambers with and without the pericardium in canine hearts.
Authors: YMaruyama, KAshikawa, SIsoyama, HKanatsuka, EIno-Oka, TTakishima
Journal: Circulation Research (1982)

By using excised postmortem hearts obtained from 15 mongrel dogs with the pericardium intact, we investigated mechanical interactions between the four heart chambers from the standpoint of ventricular pressure-volume relationships. The interactions investigated were those between (1) the atrium and the ventricle, (2) the right ventricle and left ventricles, (3) the atrium and one ventricle vs. the other ventricle, and finally (4) the left and right atrium and the right ventricle vs. the left ventricle. For these purposes, we inserted compliant balloons into the four heart chambers without injuring the pericardium, i.e., we incised the base of the atria which was not covered with the pericardium. We obtained the right and/or left ventricular pressure-volume relationships under a constant pressure in three other heart chambers by changing the height of the reservoir connected to each balloon. As a result, both ventricular pressure-volume relationships were hardly affected by an increase in the atrial pressu...
Trends in Out-of-Pocket Healthcare Expenses Before and After Passage of the Patient Protection and Affordable Care Act
Authors: Krishna Vangipuram Suresh, Kevin Wang, Adam Margalit, Amit Jain
Journal: JAMA Network Open (2021)

This cross-sectional study analyzes trends in out-of-pocket (OOP) health expenses in the United States during the last 2 decades and compares the distribution of services that contribute most to OOP spending.
Analysis of cranial neural crest distribution in the developing heart using quail-chick chimeras.
Authors: M TPhillips, M LKirby, GForbes
Journal: Circulation Research (1987)

Previous studies have shown that ablation of cranial neural crest results in heart malformations in chick embryos. Cranial neural crest cells populate all of the pharyngeal arches and provide the mesenchymal walls of the aortic arch arteries. Neural crest cells migrate from the pharyngeal apparatus into the outflow region of the heart. However, it is not known which of the pharyngeal arches contribute ectomesenchyme to the developing heart nor has a pattern of distribution in the outflow region been established. In the present study, premigratory presumptive arch neural crest from quail embryos was grafted homotopically onto early chick embryos. On Day 6 of incubation, the chimeric embryos were fixed and processed for histological evaluation. The neural crest providing mesenchyme to pharyngeal arches 1 and 2 was not associated with the developing heart. Neural crest presumptive for arches 3, 4, and 6 was found distributed to the outflow region of the heart. Neural crest from arch 4 contributed the largest...
A Control Telephone Call 14 Days after Endoscopy May not be Necessary: Anecdotical Detection of Sars-Cov-2 Infection Following an Endoscopic Procedure
Authors: M Bustamante-Balén, L Gorriz, M Botella, VL Zuñiga Garcia, N Alonso, L Argüello, C Sanchez, M García Campos, V Pons-Beltrán
Journal: Endoscopy (2021)

Aims Some guidelines suggest to contact patients 14 days after the endoscopic procedure to evaluate their clinical situation, aiming to identify nosocomial SARS-CoV-2 infection. Our aim was to assess the clinical usefulness of this recommendation in an endoscopy unit during the first wave and the recovery phase of the COVID-19 pandemic.