tbuckley/cabot-search huggingface dataset:
Kidney biopsy.
Authors: D H Rose, R P Burden, P E Davies, M S Knapp
Journal: BMJ (1980)

conceded, a multifactorial disease then -high salt intake may play a significant permissive role without necessarily requiring that hypertensives consume more than normotensives.This high salt intake may allow the clinical expression of a number of other genetic and environmental factors.A parallel situation is seen in the epidemio- logy of diabetes.Australian Aborigines have a high prevalence of diabetes yet there is no difference in the calorie intake between diabetics (1500 of the population) and non- diabetics'.Similar findings have been derived from various other ethnic groups.Yet no one would deny that calorie intake is the single most important environmental factor involved in the expression of insulin-dependent diabetes: increasing calorie intake results in the emergence of diabetes in populations, while a reduced calorie intake represents the single best treatment modality for established diabetes.Parenthetically, hypertension is also seen in more rather than less urbanised Aboriginals with a greater age-related incre- ment in the former.2Aboriginals are known to use large amounts of salt but regrettably no sodium consumption or excretion data was obtained during our studies.For the present, and particularly in the light of other studies, the data of Beevers and colleagues do not exclude salt as being a significant (even major) cause of hypertension in the community.
Table of Contents
Authors: M Lumish, N Tarazona, Y Janjigian, M Eriksson, H Joensuu, I Tannock, E Baudin, M Caplin, R Garcia-Carbonero, N Fazio, P Ferolla, P Filosso, A Frilling, W De Herder, D Hörsch, U Knigge, C Korse, E Lim, C Lombard-Bohas, M Pavel, J Scoazec, A Sundin, P Bossi, A Chan, L Licitra, A Trama, E Orlandi, E Hui, J Halámková, S Mattheis, B Baujat, J Hardillo, L Smeele, C Van Herpen, A Castro, J.-P Machiels, W Yu, J Hurley, D Roberts, S Chakrabortty, D Enderle, M Noerholm, X Breakefield, J Skog, G Carioli, M Malvezzi, P Bertuccio, P Boffetta, F Levi, C Vecchia, E Negri, M Martin, C Zielinski, M Ruiz-Borrego, E Carrasco, N Turner, E Ciruelos, M Muñoz, B Bermejo, M Margeli, A Anton, Z Kahan, T Csöszi, M Casas, L Murillo, S Morales, E Alba, E Gal-Yam, A Guerrero-Zotano, L Calvo, J De La Haba-Rodriguez, M Ramos, I Alvarez, A Garcia-Palomo, C Huang Bartlett, M Koehler, R Caballero, M Corsaro, X Huang, J Garcia-Sáenz, J Chacón, C Swift, C Thallinger, M Gil-Gil, C Denkert, M Untch, S Benz, A Schneeweiss, K Weber, S Schmatloch, C Jackisch, H Sinn, J Golovato, T Karn, F Marmé, T Link, J Budczies, V Nekljudova, W Schmitt, E Stickeler, V Müller, P Jank, R Parulkar, E Heinmöller, J Sanborn, C Schem, B Sinn, P Soon-Shiong, M Van Mackelenbergh, P Fasching, S Rabizadeh, S Loibl, X Wu, J Zhu, R Yin, J Yang, J Liu, J Wang, L Wu, Z Liu, Y Gao, D Wang, G Lou, H Yang, Q Zhou, B Kong, Y Huang, L Chen, G Li, R An, K Wang, Y Zhang, X Yan, X Lu, W Lu, M Hao, L Wang, H Cui, Q Chen, G Abulizi, X Tian, H Wen, C Zhang, J Hou, M Mirza
Journal: Annals of Oncology (2021)
Bornholm Disease
Authors: A. McE. Turnbull
Journal: BMJ (1947)

estimations are not sufficient A tendency to take lightly possible toxic effects may end in disaster.(3) Failure, disappointment, or completely unreliable con- clusions are likely to be drawn if used on cases other than the straightforward lepromatous type.It is to be remembered that the minority of the cases of leprosy in most countries are lepromatous.& (4) Even though the dliaminodiphenyl sulphone derivatives proved to be effective in: lepromatous leprosy, which is everyone's sincere hope, the leprosy problem would not, be-solved.It is essential to a better understanding of the disease that pathological studies, especially in connexion with cellular re- actions in the skin, and epidemiological surveys should be continued.A proper appreciation of preventive measures, both with regard to infection as well as to the correction and prevention of deformities, is equally important.To reduce the problem of leprosy merely to one of therapeutics is to invite disaster and disillusionment.-Iam, etc., London, N.1.
Percutaneous cholecystolithotomy
Authors: M J Kellett, J E A Wickham, R C G Russell
Journal: BMJ (1988)

A percutaneous method was used to remove stones from otherwise normal gall bladders, as assessed by cholecystography and ultrasonography. The procedure was performed in a single stage under general anaesthesia, adopting the method and instruments used for one stage percutaneous nephrolithotomy. A Foley catheter was left in the gall bladder and the system checked with contrast at 10 days to ensure free drainage and exclude residual calculi. Seven out of eight patients had a successful percutaneous cholecystolithotomy. An adequate track could not be secured in one man; he had an uneventful cholecystectomy under the same anaesthetic. Follow up at three months of the seven patients showed no calculi and no complications. Percutaneous cholecystolithotomy may prove complementary to extracorporeal shockwave lithotripsy in patients in whom there is difficulty focusing the shock waves on the gall bladder or who have had incomplete disintegration of stones.
Maternal deaths.
Authors: A H Morley
Journal: BMJ (1970)

MD 601venereal disease, demand for abortions, or of battered babies?Of course there is need for agencies where birth control facilities can be obtained.The disadvantage of the "slot machine" provision of contraceptives or the old "buy me and stop one" principle is that they may prevent from seeking advice the very people who need it most.The real tragedies are due to ignorance, insecurity and the results of permissiveness, whether fashionable or not.The great need is for more opportunities for mature counsel- ling, and for responsible parenthood.We need far more experiments in how to provide services and support for those who are most in need; more health visitors and auxiliaries to identify families at risk before the baby is battered; and more experiments in how to train doctors and nurses who can provide these services.-Iam, etc.,
MEDICAL NEWS
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Behavioral Interventions to Reduce Cardiovascular Risk Among People with Severe Mental Disorder
Authors: Amanda L. Baker, Erin Forbes, Sonja Pohlman, Kristen McCarter
Journal: Annual Review of Clinical Psychology (2022)

Cardiovascular disease (CVD) is the leading cause of death among people with severe mental disorder (SMD). CVD risk factors occur at the individual, health system, and socio-environmental levels and contribute not only to high rates of CVD but also to worsening mental health. While acknowledging this wider context, this review focuses on behavioral interventions for seven CVD risk behaviors-smoking, physical inactivity, excessive alcohol consumption, low fruit and vegetable intake, inadequate sleep, poor social participation, and poor medication adherence-that are common among people with SMD. We survey recent meta-reviews of the literature and then review additional key studies to provide clinical recommendations for behavioral interventions to reduce CVD risk among people with SMD. A transdiagnostic psychological approach from the start of mental health treatment, drawing upon multidisciplinary expertise to address multiple risk behaviors, is recommended.
Facilitating Influenza and Pneumococcal Vaccination Through Standing Orders Programs
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GENEVA
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prognostic value of the perfused hepatic mass . Liver Disease Program, Dept. of Medicine, Division of Gastroenterology, Dept. of Radiology, Division of Nuclear Medicine, University of California, Irvine and Dept. of Pathology, Division of Liver Unit Laboratories, Univ. of Southern California and Los Rancho Amigos Hospital, Downey, California
Journal: Hepatology (1995)
Forecasting motherhood
Authors: W. R. Barclay
Journal: JAMA (1982)

Forecasting trends in births and deaths is as difficult as predicting next week's weather. The data on which the forecast is made may be reliable but unforeseen circumstances can lead to unforeseen results. Adams et al, in this issue ofThe JOURNAL(p 493), predicted decline of births in the 1980s to teenagers and an increase in births to women older than 35 years. This could be a "good news/bad news" story. The good news is that fewer children will be born to young mothers ill-prepared to care for them. The bad news is that we can expect babies born to older women to show a higher incidence of birth defects. However, a number of social trends and medical forces that were not discussed by Adams and colleagues could upset their projections. Federal and state legislatures are currently erecting obstacles to teenagers' access to abortion, and pro-life groups are busy
Manuscripts Approved for JNCI, November 1 to December 1, 1970
Journal: JNCI Journal of the National Cancer Institute (1971)

Manuscripts Approved for JNCI, November 1 to December 1, 1970 Get access JNCI: Journal of the National Cancer Institute, Volume 46, Issue 1, January 1971, Pages 214–215, https://doi.org/10.1093/jnci/46.1.214-a Published: 01 January 1971
Genetics and Genomics of Pulmonary Arterial Hypertension
Authors: Rajiv D. Machado, Oliver Eickelberg, C. Gregory Elliott, Mark W. Geraci, Masayuki Hanaoka, James E. Loyd, John H. Newman, John A. Phillips, Florent Soubrier, Richard C. Trembath, Wendy K. Chung
Journal: Journal of the American College of Cardiology (2009)
The interactions of CAP and LYN with the insulin signaling transducer CBL play an important role in polycystic ovary syndrome
Authors: Haoran Shen, Xiao Xu, Zhongpeng Fu, Chengjie Xu, Yao Wang
Journal: Metabolism (2022)

Background Polycystic ovary syndrome (PCOS) is a hormonal disorder characterized by hyperandrogenism, ovulatory dysfunction, and insulin resistance. Evidence suggests that aberrations in insulin signaling-associated pathways may underlie PCOS pathogenesis. Our aim was to investigate the molecular mechanisms underlying PCOS and associated insulin resistance using in silico analyses, in vitro cell models, and in vivo murine models. Methods R-based bioinformatics analysis was performed on granulosa cell microarray data from three human cohorts: healthy control, PCOS patients without insulin resistance, and PCOS patients with insulin resistance. Transgenic human granulosa cell models were utilized for in vitro studies. Transgenic murine models of dehydroepiandrosterone (DHEA)-induced PCOS were utilized for in vivo studies. Results Sorbin and SH3 Domain Containing 1 (SORBS1), the parent gene of the insulin receptor-associated Casitas B-lineage lymphoma protein (CBL)-associated protein (CAP), is a key downregulated gene in PCOS patients with insulin resistance. CAP binding to CBL reduced CBLY731 phosphorylation, CBL-phosphoinositide 3-kinase (PI3K) p85α interactivity, protein kinase B (Akt)S473 phosphorylation, and NFκB-induced inflammatory marker expression but enhanced CRKII-mediated membrane GLUT4 translocation in granulosa cells. In contrast, the tyrosine kinase Lck/Yes-Related Novel Protein (LYN) is upregulated in PCOS patients with insulin resistance. LYN binding to CBL enhanced CBLY731 phosphorylation, CBL-PI3K p85α interactivity, AktS473 phosphorylation, and NFκB-induced inflammatory marker expression but did not impact membrane GLUT4 translocation. In PCOS mice, Cap overexpression, Cap transactivation by metformin, or enhancing Cbl-CrkII binding improved insulin sensitivity and ovarian dysfunction (i.e., estrous cycle disruption, cyst-like follicle formation, and sex hormone dysregulation). In contrast, Lyn knockdown, Lyn inhibition by PP2, or CBL-PI3K p85α blockade improved only ovarian dysfunction. Cbl3YF phosphomutant overexpression (which enhances Cbl-CrkII binding but blocks Cbl-PI3K p85α binding) ameliorated both ovarian dysfunction and insulin resistance. Conclusions The interactions of CAP and LYN with CBL, and the resulting effects on CBL phosphorylation and activity, may play an important role in PCOS pathogenesis. Targeting these players may be a viable therapeutic strategy for PCOS.
Hypersensitivity Reactions to Selpercatinib Treatment With or Without Prior Immune Checkpoint Inhibitor Therapy in Patients With NSCLC in LIBRETTO-001
Authors: Caroline E. McCoach, Christian Rolfo, Alexander Drilon, Mario Lacouture, Benjamin Besse, Koichi Goto, Viola W. Zhu, Daniel S.W. Tan, Stephanie Farajian, Laura A. Potter, Jennifer F. Kherani, Victoria Soldatenkova, Elizabeth A. Olek, Catherine E. Muehlenbein, Keunchil Park
Journal: Journal of Thoracic Oncology (2022)

Immune checkpoint inhibitor (ICI) therapy has been found to increase the risk/severity of immune-mediated adverse events with subsequent kinase inhibitor treatment in oncogenically driven cancers. We explored the risk for hypersensitivity with selpercatinib, a first-in-class highly selective and potent, central nervous system-active RET inhibitor, in prior ICI-treated patients with RET fusion-positive NSCLC compared with their ICI-naive counterparts.
Short Notes on the Opinions and Practice of the Late John Pearson, Esq., F.R.S., on Syphilitic Disease
Authors: W. S. Oke
Journal: BMJ (1848)

513-cdolir.'-His wmaster, seeing bow ill he was, ordered him to bed, and sent for a surgeon, *ho, as soon as be A* the tumour, gave the most udfavourable prognosis.He gave no hope of life being saved.He applied refriger-Att lotions,and 'a bandsge to the tumour, and ordered the patient to be prorided with brandy atid water.
Ectopic pregnancy.
Authors: R. J. Norman
Journal: BMJ (1988)

exertional rhinorrhoea inhalation of cold dry air elicited a mean threefold increase in symptom scores and a mean sixfold increase in histamine concentrations in lavage fluid, accompanied by significant increases of prostaglandin D2, leukotrienes, tosyl-L-arginine methyl esterases, and kinins.'2No change in mediator concentra- tions were detected after a control inhalation of warm and moist air.'The release of inflammatory mediators from the nasal mucosa was associated with an increase in the osmolarity of the nasal secretions.3The findings that nasal lavage with hyperosmolar solutions induces symptomatic rhinorrhoea, which was concomitant with in- creased concentrations of inflammatory mediators in nasal lavage fluid, support the view that cold dry air elicits release of mediators through a local hyperosmolar stimulus to the nasal membrane.4In vitro studies of basophils and mast cells of the lung have shown that an increase in the osmolarity of the surrounding medium is a potent stimulus for secretion of mediators.57Thus mast cell de- granulation due to changes in airway osmolarity may be important in the aetiology of exercise induced rhinorrhoea.
Road blindness.
Authors: E Grattan
Journal: BMJ (1983)

Glutamate, the major excitatory neurotransmitter in the CNS, is implicated in both normal neurotransmission and excitotoxicity. Numerous <i>in vitro</i> findings indicate that the ionotropic glutamate receptor, AMPAR, can rapidly traffic from intracellular stores to the plasma membrane, altering neuronal excitability. These receptor trafficking events are thought to be involved in CNS plasticity as well as learning and memory. AMPAR trafficking has recently been shown to be regulated by glial release of the proinflammatory cytokine tumor necrosis factor α (TNFα) <i>in vitro</i>. This has potential relevance to several CNS disorders, because many pathological states have a neuroinflammatory component involving TNFα. However, TNFα-induced trafficking of AMPARs has only been explored in primary or slice cultures and has not been demonstrated in preclinical models of CNS damage. Here, we use confocal and image analysis techniques to demonstrate that spinal cord injury (SCI) induces trafficking of AMPARs to the neuronal membrane. We then show that this effect is mimicked by nanoinjections of TNFα, which produces specific trafficking of GluR2-lacking receptors which enhance excitotoxicity. To determine if TNFα-induced trafficking affects neuronal cell death, we sequestered TNFα after SCI using a soluble TNFα receptor, and significantly reduced both AMPAR trafficking and neuronal excitotoxicity in the injury penumbra. The data provide the first evidence linking rapid TNFα-induced AMPAR trafficking to early excitotoxic secondary injury after CNS trauma <i>in vivo</i>, and demonstrate a novel way in which pathological states hijack mechanisms involved in normal synaptic plasticity to produce cell death.
Human CD34+ very small embryonic-like stem cells can give rise to endothelial colony-forming cells with a multistep differentiation strategy using UM171 and nicotinamide acid
Authors: Alison Domingues, Elisa Rossi, Kamila Bujko, Grégoire Detriche, Ulysse Richez, Adeline Blandinieres, Magdalena Kucia, Janina Ratajczak, David M. Smadja, Mariusz Z. Ratajczak
Journal: Leukemia (2022)
Medical Paris of To - Day
Authors: E. Hart
Journal: BMJ (1889)

war.It is the natural tendency of all medical officers to clear out their hospitals by sending lhome the sick with too little discrimi- nation; unless this is checked, the fightino strength of an army will soon fall off."How will this be I medical practitioners -unused to the habits of soldiers are called upon to act instead of army surgeons?In most European armies the medical officers seem to be treated with the respect and distinction due to their profession and mili- tary status.In Russia a title of high nobility was recently con- ferred on the chief of the Army MIedical Department, and only the other day the Grand Cross of the Legion of Honour, the highest distinction in France, was given to a medicaI officer on his retire- ment from active service (M\edecin Inspecteur-G6n6ral Didiot), amid the congratulations of officers of all branches of the service.Had he been a field-marshal, the French Government could not have given him a higher decoration.Such honourable distinctions give a prestige to the whole medical service, and are calculated to animate every medical officer to increased zeal in discharge of his military and medical duties.It would be of immense advantage if the good feeling and im- partiality whiclh prompt from time to time such tributes to the worth of the medical profession in other countries were extended in a like degree to the members of the profession in Great Britain.
Failure with the new triphasic oral contraceptive Logynon.
Journal: BMJ (1982)

17 30 minutes atrial fibrillation recurred, and ouabain 0-5 mg intravenously failed to reduce the rate.Amiodarone (300 mg intravenously over 10 minutes) reduced the apex rate to 90/min, after which an intravenous infusion was cstablished (600 mg per 24 hours for 48 hours); over the same period he was given digitalis.The next day he reverted to sinus rhythm and remained well.
Pink disease.
Authors: C. C. Forsyth, D. C. Savage
Journal: BMJ (1968)

asthmaticus is often very low (well below 40 mm.Hg), which makes them highly vulner- able to sudden death.The single most important early measure in preventing death in these patients is probably giving them oxygen.Their Pco2 is usually satisfactory, and 100% oxygen can be given with safety.General practitioners should perhaps keep a portable supply of oxygen to be given to the patient while waiting for the ambulance, where the oxygen should be continued.Simple bronchodilators like aminophylline do not appear to influence the arterial Po, but by producing some bronchodilatation they may produce subjective relief and reduce the work of breathing.There is a prevalent fear among general practitioners of giving patients with chronic asthma corticosteroids.Depriving some chronic asthmatics, especially young ones, of long-term corticoids can have tragic reper- cussions.Apart from the social and educa- tional consequences that uncontrolled chronic asthma can produce, it can result in irrevers- ible pulmonary damage at an early age.The assessment of chronic asthmatics should be carried out only in hospital, where true responders can be selected for long-term corticoid therapy.'The important function of the general practitioner is to recognize the chronic asthmatic for hospital corticoid assessment.-Iam, etc.,