POS1351 CAUSES OF HOSPITALIZATION IN BEHÇET SYNDROME
Authors: Y. Ozguler, G. Hatemi, A. S. Pala, S. N. Esatoglu, S. Ugurlu, E. Seyahi, M. Melikoglu, I. Fresko, H. Ozdogan, S. Yurdakul, H. Yazici, V. Hamuryudan
Journal: Annals of the Rheumatic Diseases (2021)

Background: The causes of hospitalization may provide important information on the course of diseases and treatment-related adverse effects. Objectives: We aimed to determine the causes and outcome of hospitalizations among patients with Behçet Syndrome (BS) in a dedicated center. Methods: We surveyed hospitalization records in our clinic between January 2002 and December 2019 and identified those with a diagnosis of BS. The records of these patients were reviewed for demographic and clinical features, causes of hospitalization and outcome. We divided hospitalization causes into 2 as being BS related (organ involvement or deterioration) and non-BS related (treatment complication or others). Results: Three-hundred and thirty BS patients (75% men, mean age 37.7 ±11.4 SD years) were hospitalized for a total of 456 times during 18 years. The mean disease duration was 10.8± 8.8 SD years. Two-hundred and ninety-one (64%) patients were using immunosuppressives (IS) with or without corticosteroids (CSs) and 72 (16%) of them were under biologic treatment at the time of hospitalization. The mean duration of hospitalization was 12.7±10.7 SD days. The reasons for hospitalization were directly related to BS in 259 patients (57%) and non-related to BS in 191 (42%). Six patients were hospitalized for both BS and non-BS related reasons at the same time. The most common reasons were vascular involvement (n=169, 64%) for BS related reasons and infections (n=64, 32%) for non-BS related reasons (Table 1). Patients hospitalized for BS related causes were younger (35.2±10.6 vs 41.1±11.7, p&lt;0.001), had short mean disease duration (8.5±7.5 vs. 13.6±9.4 years, p&lt;0.001), stayed shorter in the hospital (11.6±8.6 vs 14.0±12.9 days p=0.03) and had less frequent IS±CSs use (59% vs 70%, p=0.02) compared to those with non-BS related hospitalizations. There were no differences between the groups regarding gender distribution (203 M/62 F vs. 143 M/54 F) and use of biologic agents (15% vs 17%). Three patients died during hospitalization. The reasons were malignancy, infection and right heart failure due to pulmonary artery thrombosis and pulmonary hypertension, respectively. Conclusion: Vascular involvement is the leading cause of hospitalization among BS patients, followed by infections. The predominance of men among hospitalized patients underlines the relatively severe course of BS in men. The retrospective design and inclusion of patients who were hospitalized only in the rheumatology unit are limitations of this study. Table 1. Distributions of BS related and non-BS related reasons of hospitalizations BS patients hospitalized with BS related reasons (n of pts=195, n of hospitalizations=265)* BS patients hospitalized with non-BS related reasons (n of pts=170, n of hospitalizations=197)* Causes of hospitalizations (per hospitalization) Vascular inv. (n=169, 64 %) Pulmonary artery inv. (n=64, 24 % ) Deep vein thrombosis (n=39, 15 % ) Budd-Chiari synd. (n=24, 9% ) Vena cava inf. thrombosis (n=19, 7 % ) Peripheral artery inv. (n=15, 6 % ) Vena cava sup. thrombosis (n=14, 5 % ) Aorta inv. (n=14, 5% ) Coronary artery inv. (n=4, 2 % ) Infection (n=64, 32%) Pneumonia (n=17, 8% ) Tuberculosis (n=8, 4% ) Urinary tract inf (n=7, 4% ) Gastroenteritis (n=4, 2% ) Osteomyelitis (n=3, 2% ) Septic arthritis (n=3, 2% ) Aspergillosis (n=2, 1% ) Nocardia (n=1, 1% ) Salmonella (n=1, 1% ) Others (n=18, 9% ) Neurologic inv. (n=50, 19 %) Parenchymal inv. (n=37, 14% ) Dural sinus thrombosis (n=13, 5% ) Drug side effects other than infections (n=29, 15 %) Interferon (n=10, 5% ) Azathioprine (n=7, 4% ) Cyclosporine (n=5, 3% ) Steroid (n=3, 2% ) TNF antagonists (n=3, 2% ) IVIG (n=1, 1% ) GI inv. (n=18, 7%) Additional rheumatologic diseases (n=17, 9%) Joint inv. (n=12, 5%) Renal disease (n=16, 8 %) Mucocutaneous inv. (n=10, 4%) Cardiovascular dis. (n=12, 6%) Eye inv. (n=8, 3%) Avascular necrosis (n=4, 2%) Others (n=8, 3%) Malignancy (n=11, 6%) Others (n=40, 20%) *Some patients were hospitalized more than one times and for both BS related and non-BS related reasons at different time and had more than one type of BS related and/or non-BS related reasons. Disclosure of Interests: None declared