tbuckley/cabot-search huggingface dataset:
DNA methylation profiles differ in responders versus non-responders to anti-PD-1 immune checkpoint inhibitors in patients with advanced and metastatic head and neck squamous cell carcinoma
Authors: Angelika Martina Starzer, Gerwin Heller, Erwin Tomasich, Thomas Melchardt, Katharina Feldmann, Teresa Hatziioannou, Stefan Traint, Christoph Minichsdorfer, Ursula Schwarz-Nemec, Maja Nackenhorst, Leonhard Müllauer, Matthias Preusser, Anna Sophie Berghoff, Thorsten Fuereder
Journal: Journal for ImmunoTherapy of Cancer (2022)

Background Biomarkers for response prediction to anti-programmed cell death 1 (PD-1) immune checkpoint inhibitors (ICI) in patients with head and neck squamous cell carcinoma (HNSCC) are urgently needed for a personalized therapy approach. We investigated the predictive potential of inflammatory parameters and DNA methylation profiling in patients with HNSCC treated with anti-PD-1 ICI. Methods We identified patients with HNSCC that were treated with anti-PD-1 ICI therapy in the recurrent or metastatic setting after progression to platinum-based chemotherapy in two independent centers. We analyzed DNA methylation profiles of &gt;850.000 CpG sites in tumor specimens of these patients by Infinium MethylationEPIC microarrays, immune cell density in the tumor microenvironment (CD8, CD3, CD45RO, forkhead box P3 (FOXP3), CD68), PD-1 and programmed cell death ligand 1 (PD-L1) expression by immunohistochemistry, and blood inflammation markers (platelet-to-lymphocyte ratio, leucocyte-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio). DNA methylation profiles and immunological markers were bioinformatically and statistically correlated with radiological response to anti-PD-1 ICI. Results 37 patients with HNSCC (median age of 62 years; range 49–83; 8 (21.6%) women, 29 (78.4%) men) were included (Center 1 N=26, 70.3%; Center 2 N=11, 29.7%). Median number of prior systemic therapies was 1 (range 1–4). Five out of 37 (13.5%) patients achieved an objective response to ICI. Median progression-free survival and median overall survival times were 3.7 months (range 0–22.9) and 9.0 months (range 0–38.8), respectively. Microarray analyses revealed a methylation signature including both hypomethylation and hypermethylation which was predictive for response to ICI and included several genes involved in cancer-related molecular pathways. Over-represented differentially methylated genes between responders and non-responders were associated with ‘Axon guidance’, ‘Hippo signaling’, ‘Pathways in cancer’ and ‘MAPK signaling’. A statistically significant correlation of PD-L1 expression and response was present (p=0.0498). Conclusions Our findings suggest that tumor DNA methylation profiling may be useful to predict response to ICI in patients with HNSCC.
HSR22-166: Patient Demographic and Socioeconomic Differences in Non-Small Cell and Small Cell Lung Cancers: Impact on Outcomes. A National Cancer Database Analysis.
Authors: Logan Roof, Wei Wei, James P Stevenson
Journal: Journal of the National Comprehensive Cancer Network (2022)

"HSR22-166: Patient Demographic and Socioeconomic Differences in Non-Small Cell and Small Cell Lung Cancers: Impact on Outcomes. A National Cancer Database Analysis." published on 31 Mar 2022 by National Comprehensive Cancer Network.
Clonal hematopoiesis in primary immune thrombocytopenia
Authors: Yanming Wang, Tianshu Yu, Qiaofeng Dong, Shuang Liu, Yafei Yu, Hong Yu Zhao, Ji Ma, Lin Dong, Liang Wang, Daoxin Ma, Yajing Zhao, Yu Hou, Xinguang Liu, Jun Peng, Ming Hou
Journal: Blood Cancer Journal (2022)
SEPSIS-ASSOCIATED TYPE 2 VERSUS TYPE 1 MYOCARDIAL INFARCTION WITH DIFFERENCES IN COMORBIDITIES AND OUTCOMES: A PROPENSITY-MATCHED NATIONWIDE ANALYSIS (2018)
Authors: Akhil Jain, Priya Shenwai, Ankita Lakshmanan, Frailyn Nunez Guzman, Neelima Gaddam, Ozo Akah, Shristee Karki, Samir Ghimire, None Neha, Aamer Mohammad, Rupak Desai, Bhavyasri Merugu
Journal: Journal of the American College of Cardiology (2022)
Serotonergic neurons translate taste detection into internal nutrient regulation
Authors: Zepeng Yao, Kristin Scott
Journal: Neuron (2022)

The nervous and endocrine systems coordinately monitor and regulate nutrient availability to maintain energy homeostasis. Sensory detection of food regulates internal nutrient availability in a manner that anticipates food intake, but sensory pathways that promote anticipatory physiological changes remain unclear. Here, we identify serotonergic (5-HT) neurons as critical mediators that transform gustatory detection by sensory neurons into the activation of insulin-producing cells and enteric neurons in Drosophila. One class of 5-HT neurons responds to gustatory detection of sugars, excites insulin-producing cells, and limits consumption, suggesting that they anticipate increased nutrient levels and prevent overconsumption. A second class of 5-HT neurons responds to gustatory detection of bitter compounds and activates enteric neurons to promote gastric motility, likely to stimulate digestion and increase circulating nutrients upon food rejection. These studies demonstrate that 5-HT neurons relay acute gustatory detection to divergent pathways for longer-term stabilization of circulating nutrients.
LONG-TERM SAFETY AND TOLERABILITY OF ACORAMIDIS (AG10) IN SYMPTOMATIC TRANSTHYRETIN AMYLOID CARDIOMYOPATHY: UPDATED ANALYSIS FROM AN ONGOING PHASE 2 OPEN-LABEL EXTENSION STUDY
Authors: Ahmad Masri, Mandar Aras, Rodney H. Falk, Martha Grogan, Daniel Jacoby, Daniel P. Judge, Sanjiv Jayendra Shah, Ronald Witteles, Alan X. Ji, Paul W. Wong, Xiaofan Cao, Rebecca Vanlandingham, Leonid Katz, Uma Sinha, Jonathan C. Fox, Mathew S. Maurer
Journal: Journal of the American College of Cardiology (2022)
IMPACT OF CHRONIC KIDNEY DISEASE ON SHORT- AND INTERMEDIATE -TERM OUTCOMES IN PATIENTS WITH TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Byomesh Tripathi, Sopan Lahewala, Siamac Yazdchi, Shilpkumar Arora, Samuel Unzek, I-Hui Chiang, Marvin H. Eng, Prakash Balan
Journal: Journal of the American College of Cardiology (2022)
Soft Wireless Bioelectronics Designed for Real‐Time, Continuous Health Monitoring of Farmworkers
Authors: Yun‐Soung Kim, Jihoon Kim, Roxana Chicas, Nezahualcoyotl Xiuhtecutli, Jared Matthews, Nathan Zavanelli, Shinjae Kwon, Sung Hoon Lee, Vicki S. Hertzberg, Woon‐Hong Yeo
Journal: Advanced Healthcare Materials (2022)

Hotter summers caused by global warming and increased workload and duration are endangering the health of farmworkers, a high-risk population for heat-related illness (HRI), and deaths. Although prior studies using wearable sensors show the feasibility of employing field-collected data for HRI monitoring, existing devices still have limitations, such as data loss from motion artifacts, device discomfort from rigid electronics, difficulties with administering ingestible sensors, and low temporal resolution. Here, this paper introduces a wireless, wearable bioelectronic system with functionalities for continuous monitoring of skin temperature, electrocardiograms (ECG), heart rates (HR), and activities, configured in a single integrated package. Advanced nanomanufacturing based on laser machining allows rapid device fabrication and direct incorporation of sensors with a highly breathable substrate, allowing for managing excessive sweating and multimodal stresses. To validate the device's performance in agricultural settings, the device is applied to multiple farmworkers at various operations, including fernery, nursery, and crop. The accurate data recording, including high-fidelity ECG (signal-to-noise ratio: >20 dB), accurate HR (r = 0.89, r2 = 0.65 in linear correlation), and reliable temperature/activity, confirms the device's capability for multiparameter health monitoring of farmworkers.
LncRNA Uc003xsl.1-Mediated Activation of the NFκB/IL8 Axis Promotes Progression of Triple-Negative Breast Cancer
Authors: Ying Xu, Wei Ren, Qingjian Li, Chaohui Duan, Xiaorong Lin, Zhuofei Bi, Kaiyun You, Qian Hu, Ning Xie, Yunfang Yu, Xiaoding Xu, Hai Hu, Herui Yao
Journal: Cancer Research (2021)

Aberrant activation of NFκB orchestrates a critical role in tumor carcinogenesis; however, the regulatory mechanisms underlying this activation are not fully understood. Here we report that a novel long noncoding RNA (lncRNA) Uc003xsl.1 is highly expressed in triple-negative breast cancer (TNBC) and correlates with poor outcomes in patients with TNBC. Uc003xsl.1 directly bound nuclear transcriptional factor NFκB-repressing factor (NKRF), subsequently preventing NKRF from binding to a specific negative regulatory element in the promoter of the NFκB-responsive gene IL8 and abolishing the negative regulation of NKRF on NFκB-mediated transcription of IL8. Activation of the NFκB/IL8 axis promoted the progression of TNBC. Trop2-based antibody-drug conjugates have been applied in clinical trials in TNBC. In this study, a Trop2-targeting, redox-responsive nanoparticle was developed to systematically deliver Uc003xsl.1 siRNA to TNBC cells in vivo, which reduced Uc003xsl.1 expression and suppressed TNBC tumor growth and metastasis. Therefore, targeting Uc003xsl.1 to suppress the NFκB/IL8 axis represents a promising therapeutic strategy for TNBC treatment.
IN-HOSPITAL OUTCOMES PERCUTANEOUS CORONARY INTERVENTION IN ADULTS WITH ACYANOTIC CONGENITAL HEART DISEASE
Authors: Manasvi Gupta, Neelkumar Patel, Dhrubajyoti Bandyopadhyay, Sandipan Chakraborty, Birendra Amgai, Zeel Patel, Adrija Hajra
Journal: Journal of the American College of Cardiology (2022)
Improving survival in neuro-oncology is a struggle; we cannot allow ourselves to also struggle with issues of diversity
Authors: Annick Desjardins
Journal: Neuro-Oncology (2022)

The events of the last few years have brought the importance of acknowledging errors made in the past to the forefront, while also committing to a more equitable, inclusive, and diverse society going forward. Health inequities across racial, ethnic, gender, geographic, and socioeconomic groups have prevented minorities from sharing in the benefits of scientific advances and have made it difficult to generalize study results to all populations.1 This is far from being a novel concern. The National Institutes of Health (NIH) Revitalization Act of 1993, signed into law on June 10, 1993, directed the NIH to establish guidelines for the inclusion of women and minorities in clinical research. In “A Population Study of Clinical Trial Accrual for Women and Minorities in Neuro-Oncology Following the NIH Revitalization Act,” Reihl et al2 conducted a review of literature evaluating the impact of the NIH Revitalization Act 29 years later in improving the representation of women and minorities in therapeutic clinical trials for neuro-epithelial CNS tumors. Their team observed that, despite a small improvement in recent years, minorities and women with brain tumor diagnoses remain significantly under-accrued for neuro-oncology clinical trials when compared with Caucasians and men based on proportional disease burden and demographic-specific mortality.
IMPACT OF REPEAT RIGHT HEART CATHETERIZATIONS ON CONGESTIVE HEART FAILURE OUTCOMES: A SINGLE CENTER STUDY
Authors: Harsh Doshi, Michael Foster, Jake Rosen, Frank Fortino, Olivia Delorenzo, Doug Corsi, Jesus Eduardo Rame, Rene J. Alvarez, Alec Vishnevsky, Michael P. Savage, David L. Fischman
Journal: Journal of the American College of Cardiology (2022)
Effectiveness of 2-Dose BNT162b2 (Pfizer BioNTech) mRNA Vaccine in Preventing SARS-CoV-2 Infection Among Children Aged 5–11 Years and Adolescents Aged 12–15 Years — PROTECT Cohort, July 2021–February 2022
Authors: Ashley L. Fowlkes, Sarang K. Yoon, Karen Lutrick, Lisa Gwynn, Joy Burns, Lauren Grant, Andrew L. Phillips, Katherine Ellingson, Maria V. Ferraris, Lindsay B. LeClair, Clare Mathenge, Young M. Yoo, Matthew S. Thiese, Lynn B. Gerald, Natasha Schaefer Solle, Zuha Jeddy, Leah Odame-Bamfo, Josephine Mak, Kurt T. Hegmann, Joe K. Gerald, Jezahel S. Ochoa, Mark Berry, Spencer Rose, Julie Mayo Lamberte, Purnima Madhivanan, Felipe A. Pubillones, Ramona P. Rai, Kayan Dunnigan, John T. Jones, Karl Krupp, Laura J. Edwards, Edward J. Bedrick, Brian E. Sokol, Ashley Lowe, Hilary McLeland-Wieser, Krystal S. Jovel, Deanna E. Fleary, Sana M. Khan, Brandon Poe, James Hollister, Joanna Lopez, Patrick Rivers, Shawn Beitel, Harmony L. Tyner, Allison L. Naleway, Lauren E.W. Olsho, Alberto J. Caban-Martinez, Jefferey L. Burgess, Mark G. Thompson, Manjusha Gaglani
Journal: MMWR Morbidity and Mortality Weekly Report (2022)

The BNT162b2 (Pfizer-BioNTech) mRNA COVID-19 vaccine was recommended by CDC's Advisory Committee on Immunization Practices for persons aged 12-15 years (referred to as adolescents in this report) on May 12, 2021, and for children aged 5-11 years on November 2, 2021 (1-4). Real-world data on vaccine effectiveness (VE) in these age groups are needed, especially because when the B.1.1.529 (Omicron) variant became predominant in the United States in December 2021, early investigations of VE demonstrated a decline in protection against symptomatic infection for adolescents aged 12-15 years and adults* (5). The PROTECT† prospective cohort of 1,364 children and adolescents aged 5-15 years was tested weekly for SARS-CoV-2, irrespective of symptoms, and upon COVID-19-associated illness during July 25, 2021-February 12, 2022. Among unvaccinated participants (i.e., those who had received no COVID-19 vaccine doses) with any laboratory-confirmed SARS-CoV-2 infection, those with B.1.617.2 (Delta) variant infections were more likely to report COVID-19 symptoms (66%) than were those with Omicron infections (49%). Among fully vaccinated children aged 5-11 years, VE against any symptomatic and asymptomatic Omicron infection 14-82 days (the longest interval after dose 2 in this age group) after receipt of dose 2 of the Pfizer-BioNTech vaccine was 31% (95% CI = 9%-48%), adjusted for sociodemographic characteristics, health information, frequency of social contact, mask use, location, and local virus circulation. Among adolescents aged 12-15 years, adjusted VE 14-149 days after dose 2 was 87% (95% CI = 49%-97%) against symptomatic and asymptomatic Delta infection and 59% (95% CI = 22%-79%) against Omicron infection. Fully vaccinated participants with Omicron infection spent an average of one half day less sick in bed than did unvaccinated participants with Omicron infection. All eligible children and adolescents should remain up to date with recommended COVID-19 vaccinations.
New US Preventive Services Task Force Recommendations on Screening for Eating Disorders
Authors: Jason M. Nagata, Neville H. Golden
Journal: JAMA Internal Medicine (2022)

Cynthia Feltner, MD, MPH; Christine Peat, PhD; Shivani Reddy, MD, MS; Sean Riley, MA, MSc; Nancy Berkman, PhD; Jennifer Cook Middleton, PhD; Casey Balio, PhD; Manny Coker-Schwimmer, MPH; Daniel E. Jonas, MD, MPH
INITIATIVE TO REDUCE CONTRAST-INDUCED NEPHROPATHY IN THE CARDIAC CATHETERIZATION LAB: THE DUKE RENAL IMPAIRMENT PROGRAM
Authors: Jennifer Rymer, Angela Lowenstern, Heather King, Oakes Megan, Schuyler Jones, Cindy Green, Hayden Bosworth, Sunil Rao
Journal: Journal of the American College of Cardiology (2022)
EFFICIENCY AND SAFETY OF USING THE MODIFIED PROTOCOL FOR THE ADMINISTRATION OF THE DRUG NIFERIDIL FOR THE RELIEF OF PAROXYSMAL ATRIAL FIBRILLATION
Authors: Khava Dzaurova, Nikolay Mironov, Gagloeva Diana, Yuricheva Julia, Vladislav Vlodzyanovsky, Sokolov Sergey, Sergey Golitsyn
Journal: Journal of the American College of Cardiology (2022)
IL-1R8 silencing improves the anti-tumor function of freshly isolated human NK cells
Authors: Nadine Landolina, Francesca Romana Mariotti, Tiziano Ingegnere, Claudia Alicata, Biancamaria Ricci, Andrea Pelosi, Irene Veneziani, Bruno Giuseppe Azzarone, Cecilia Garlanda, Alberto Mantovani, Lorenzo Moretta, Enrico Maggi
Journal: Journal for ImmunoTherapy of Cancer (2022)

The inhibitory receptor interleukin-1 receptor 8 (IL-1R8) has been recently recognized to be expressed also by human natural killer (NK) cells. This study was aimed to design and optimize IL-1R8 silencing conditions in human NK cells to precisely establish the activity of such receptor in these cells. Electroporation of freshly isolated or IL-2-cultured NK cells with small interfering RNA (siRNA), resulted in a marked, even though variable, IL-1R8-silencing. Although the expression profile revealed downregulation of most genes involved in several intracellular pathways, some genes related to proliferation, expression of some chemokine receptors, antibody-dependent cell cytotoxicity and cytotoxic activity were upregulated in IL-1R8-silenced NK cells. Furthermore, upon IL-15 activation, the majority of genes involved in NK cell function were upregulated in IL-1R8-siRNA-compared with control-siRNA-transfected NK cells. More importantly, in agreement with these findings, the reduction of IL-1R8 gene expression levels resulted in enhanced expression of NK cell activation markers, production of cytokines and chemokines, and cytotoxic activity against several NK cell targets with different susceptibility to NK-mediated lysis. Similar results were obtained following stimulation with IL-18. All together these data, deeply impacting on the main effector functions of human NK cells, can lead to a better understanding of IL-1R8-mediated regulation on these cells and to the design of new strategies for improving NK cell-mediated anti-tumor responses.
NOX2 CAUSES ATRIAL REMODELING VIA INCREASED OXIDATIVE STRESS AND REACTIVE OXYGEN SPECIES PRODUCTION IN OBESITY INDUCED AF
Authors: Arvind Sridhar, Mahmud Arif Pavel, Olivia Thao Ly, Hanna Chen, Liang Hong, Srikanth Perike, Mark McCauley, Jalees Rehman, Dawood Darbar
Journal: Journal of the American College of Cardiology (2022)
Effectiveness of COVID-19 vaccines in older adults in Colombia: a retrospective, population-based study of the ESPERANZA cohort
Authors: Leonardo Arregocés-Castillo, Julián Fernández-Niño, Maylen Rojas-Botero, Andrés Palacios-Clavijo, Maryory Galvis-Pedraza, Luz Rincón-Medrano, Mariana Pinto-Álvarez, Fernando Ruiz-Gómez, Belem Trejo-Valdivia
Journal: The Lancet Healthy Longevity (2022)

BackgroundAlthough clinical trials showed that vaccines have high efficacy and safety, differences in study designs and populations do not allow for comparison between vaccines and age groups. The objective of this study was to evaluate the effectiveness of vaccines against COVID-19 in real-world conditions in adults aged 60 years and older in Colombia.MethodsIn this retrospective, population-based, matched cohort study, we evaluated the effectiveness of vaccines against COVID-19-related hospitalisation and death in people aged 60 years and older. The full cohort consisted of every person who was eligible to receive a COVID-19 vaccine in Colombia (the ESPERANZA cohort). The exposed cohort consisted of older adults who were fully vaccinated with Ad26.COV2-S, BNT162b2, ChAdOx1 nCoV-19, or CoronaVac, and who did not have a history of confirmed SARS-CoV-2 infection. The unexposed cohort were people aged 60 years and older who had not received any dose of a COVID-19 vaccine during the study period. Participant follow-up was done between March 11, 2021, and Oct 26, 2021. Vaccine effectiveness was estimated as 1– hazard ratio from cause-specific proportional hazards models in the presence of competing risks. We estimated the overall effectiveness of being fully vaccinated, as well as effectiveness for each vaccine, adjusting by main potential confounders. The effectiveness of each vaccine was also assessed by age groups (ages 60–69 years, 70–79 years, and ≥80 years).Findings2 828 294 participants were assessed between March 11 and Oct 26, 2021. For all ages, the overall effectiveness across all assessed COVID-19 vaccines at preventing hospitalisation without subsequent death was 61·6% (95% CI 58·0–65·0, p<0·0001), 79·8% (78·5–81·1, p<0·0001) for preventing death after hospitalisation with COVID-19, and 72·8% (70·1–75·3, p<0·0001) for preventing death without previous COVID-19 hospitalisation. The effectiveness of all vaccines analysed at preventing death after hospitalisation for COVID-19 was 22·6% lower in adults who were aged 80 and older (68·4% [65·7–70·9], p<0·0001) compared with adults aged between 60 and 69 years (91·0% [89·0–92·6], p<0·0001).InterpretationAll vaccines analysed in this study were effective at preventing hospitalisation and death from COVID-19 in fully vaccinated older adults, which is a promising result for the national vaccination programme against COVID-19 in Colombia and in countries where these biologics have been applied. Efforts should be improved to increase coverage among older adults. In addition, given that we observed that the effectiveness of vaccines declined with increasing age, a booster dose is also justified, which should be prioritised for older adults.FundingColombian Ministry of Health and Social Protection.
CHARACTERISTICS OF PATIENTS WITH WILD-TYPE TRANSTHYRETIN CARDIAC AMYLOIDOSIS PRESCRIBED TAFAMIDIS - A REAL-WORLD DESCRIPTIVE ANALYSIS USING ELECTRONIC HEALTH RECORDS
Authors: Rahul Bhambri, Carmine Colavecchia, Marianna Bruno, Yong Chen, Jose Alvir, Anuja Roy, jason kemner, Aaron Crowley, Darrin Benjumea, Lauren Gray Gilstrap
Journal: Journal of the American College of Cardiology (2022)
MECHANICAL THROMBECTOMY FOR PULMONARY EMBOLISM WITHOUT BLOOD LOSS
Authors: Zurain Niaz, Manjari R. Regmi, Luke Schiller, Daniel Holtz, Mohsin Salih, Prashanth Singanallur, Venkata Missula, Muhammad Adil Sheikh, Kevin Schrader, Raj Patel, Robert Kropp, Mohamad Sukkari, Abdul Moiz Hafiz, Abhishek Kalidas Kulkarni
Journal: Journal of the American College of Cardiology (2022)
PAROXYSMAL ATRIAL FIBRILLATION IN A 27-YEAR OLD WITH BRUGADA SYNDROME AND AN IMPLANTABLE CARDIOVERTER DEFIBRILLATOR
Authors: Saima Shikari, Heather H. Hesselson, Kristin Ellison, Joseph J. Souza, Aaron B. Hesselson
Journal: Journal of the American College of Cardiology (2022)
TRENDS, PREDICTORS AND OUTCOMES OF THIRTY DAY READMISSION WITH HEART FAILURE AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT:INSIGHTS FROM THE UNITED STATES NATIONWIDE READMISSION DATABASE
Authors: Salman Zahid, Mian Tanveer Ud Din, Muhammad Zia Khan, Devesh Rai, Waqas Ullah, Tamer Salhab Altamimi, Ahmed Elkhapery, Muhammad Usman Khan, Sudarshan Balla
Journal: Journal of the American College of Cardiology (2022)
Using Machine Learning to Identify Metabolomic Signatures of Pediatric Chronic Kidney Disease Etiology
Authors: Arthur M. Lee, Jian Hu, Yunwen Xu, Alison G. Abraham, Rui Xiao, Josef Coresh, Casey Rebholz, Jingsha Chen, Eugene P. Rhee, Harold I. Feldman, Vasan S. Ramachandran, Paul L. Kimmel, Bradley A. Warady, Susan L. Furth, Michelle R. Denburg
Journal: Journal of the American Society of Nephrology (2022)

Untargeted plasma metabolomic profiling combined with machine learning (ML) may lead to discovery of metabolic profiles that inform our understanding of pediatric CKD causes. We sought to identify metabolomic signatures in pediatric CKD based on diagnosis: FSGS, obstructive uropathy (OU), aplasia/dysplasia/hypoplasia (A/D/H), and reflux nephropathy (RN).
PLATYPNEA-ORTHODEOXIA SYNDROME AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT AND CONCOMITANT AORTIC ROOT ELONGATION
Authors: Aushim Kokroo, Linle Hou, Thomas F. Cunningham, Saaron Laighold, Elana Koss, Rajiv Jauhar, Sean R. Wilson
Journal: Journal of the American College of Cardiology (2022)
EXTREMELY RARE CASE OF PRIMUM, SINUS VENOSUS, AND UNROOFED CORONARY SINUS ASD IN YOUNG OBESE PATIENT
Authors: Shengnan Zheng, Muhammad Zaman, Amit Rout, Sarabjeet Suri, Agastya D. Belur, Shahab Ghafghazi
Journal: Journal of the American College of Cardiology (2022)
TRADITIONAL RISK FACTORS INCREASE THE RISK OF POOR OUTCOMES IN PATIENTS WITH CARDIAC SARCOIDOSIS
Authors: Shilpa Jasti, Muhammad Afzal, Steven Jack Kalbfleisch, Kenneth A. Ellenbogen, Frank M. Bogun, Alexandru B. Chicos, Henri Roukoz, Peter J. Zimetbaum, Francis Murgatroyd, Mikhail Torosoff, Marc Judson, Pyotr G. Platonov, Adarsh K. Bhan, Lynda E. Rosenfeld, David B. De Lurgio, Ann C. Garlitski, Melody H. Hermel, Vasanth Vedantham, Kyoko Soejima, Timm-Michael L. Dickfeld, Xiaokui Gu, Eric Puroll, Thomas C. Crawford, Jordana Kron
Journal: Journal of the American College of Cardiology (2022)