tbuckley/cabot-search huggingface dataset:
Increased 68Ga-FAPI Uptake in the Pulmonary Cryptococcus and the Postradiotherapy Inflammation
Authors: Liang Zhao, Yizhen Pang, Long Sun, Qin Lin, Haojun Chen
Journal: Clinical Nuclear Medicine (2021)

Abstract A 51-year-old man, previously treated for nasopharyngeal carcinoma, presented a newly detected pulmonary nodule. This patient underwent 18 F-FDG and 68 Ga-FAPI PET/CT to detect tumor recurrence under the prospective study NCT04416165. Both 18 F-FDG and 68 Ga-FAPI PET/CT showed intense uptake in a pulmonary nodule in the right lower lobe. In addition, 68 Ga-FAPI PET/CT demonstrated increased uptake in the nasopharynx that previously treated with radiotherapy. The pulmonary nodule was found to be cryptococcus by the CT-guided biopsy, and the increased 68 Ga-FAPI uptake in the nasopharynx was interpreted as false-positive finding due to a stable Epstein-Barr virus level and no progression on follow-up imaging.
A Correction to the Research Article Titled: “Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer” by J. Weiss, M. L. Sos, D. Seidel, M. Peifer, T. Zander, J. M. Heuckmann, R. T. Ullrich, R. Menon, S. Maier, A. Soltermann, H. Moch, P. Wagener, F. Fischer, S. Heynck, M. Koker, J. Schöttle, F. Leenders, F. Gabler, I. Dabow, S. Querings, L. C. Heukamp, H. Balke-Want, S. Ansén, D. Rauh, I. Baessmann, J. Altmüller, Z. Wainer…
Journal: Science Translational Medicine (2012)
Obinutuzumab-atezolizumab-lenalidomide for the treatment of patients with relapsed/refractory follicular lymphoma: final analysis of a Phase Ib/II trial
Authors: Franck Morschhauser, Nilanjan Ghosh, Izidore S. Lossos, M. Lia Palomba, Amitkumar Mehta, Olivier Casasnovas, Don Stevens, Sudhakar Katakam, Andrea Knapp, Tina Nielsen, Ron McCord, Gilles Salles
Journal: Blood Cancer Journal (2021)

We evaluated the triplet regimen obinutuzumab-atezolizumab-lenalidomide (G-atezo-len) for patients with relapsed/refractory (R/R) follicular lymphoma (FL) in an open-label, multicenter phase Ib/II study (BO29562; NCT02631577). An initial 3 + 3 dose-escalation phase to define the recommended phase II dose of lenalidomide was followed by an expansion phase with G-atezo-len induction and maintenance. At final analysis, 38 patients (lenalidomide 15 mg, n = 4; 20 mg, n = 34) had completed the trial. Complete response rate for the efficacy population (lenalidomide 20 mg, n = 32) at end-of-induction was 71.9% (66.7% in double-refractory patients [refractory to rituximab and alkylator] [n = 12]; 50.0% in patients with progressive disease within 24 months of first-line therapy [n = 12]). The 36-month progression-free survival rate was 68.4%. All treated patients had ≥1 adverse event (AE; grade 3-5 AE, 32 patients [84%]; serious AE, 18 patients [47%]; AEs leading to discontinuation of any study drug, 11 patients [29%]). There were 2 fatal AEs (1 merkel carcinoma, 1 sarcomatoid carcinoma; both unrelated to any study drug). The G-atezo-len regimen is effective and tolerable in patients with R/R FL. AEs were consistent with the known safety profile of the individual drugs.
Specificity of Multispiral Computed Tomography in the Diagnosis of Avascular Necrosis of the Femoral Head
Authors: D. P. Rempel, A. V. Bryukhanov, D. A. Dzhukhaev, S. D. Romanyuk
Journal: Radiology - Practice (2021)

In the span of 6 years 350 patients that were clinically and radiologically diagnosed with avascular necrosis of the femoral head, at different stages, were examined. Patients were examined using comprehensive radiation examination including radiography and multispiral computed tomography (MSCT) of the hip joints, with the aim to diagnosis avascular necrosis of the femoral head at an earlier stage. According to the results of the examination, 121 patients were diagnosed with an earlier stage of avascular necrosis of the femoral head, on 99 patients was performed core decompression via drilling, 22 patients underwent a joint preservation procedure with the removal of the necrosis tissue following with a bone-graft using bonesubstituting bioresorbable material.
Fried Foods, Gut Microbiota, and Glucose Metabolism
Authors: Lu Qi
Journal: Diabetes Care (2021)

Hot oil–based frying is a popular cooking method that makes food more appealing in texture and aromatic, thus improving palatability. Fried foods are considered unhealthy because frying may increase the energy density of foods and therefore energy intakes as well as deteriorate oils through the process of oxidation and hydrogenation, leading to a loss of unsaturated fatty acids such as linoleic and linolenic acids but increase in trans fatty acids, oil degradation, and advanced glycation end products (1,2). In epidemiological studies, high intakes of fried foods have been associated with a variety of adverse health outcomes including type 2 diabetes (T2D), although the results are not entirely consistent (3–6). The conflicting findings are partly due to the diverse types of oil used in frying foods. For instance, null associations between fried foods and T2D risk were reported in populations with fried foods prepared using mainly olive oil, which is more resistant to oxidation than other common oils used for frying such as corn oil (4). In addition, the varying compositions of the foods being fried and frying conditions (temperature, duration) may also trigger the heterogeneous results. An extra layer of complexity in the inconsistent observations is introduced by various confounding factors such as weight gain, high blood pressure, and lipidemia, which are correlated with both fried food consumption and T2D risk (1,7). The causality of fried foods in glucose dysregulation and the development of T2D could only be detected in investigations in which the cofounding was rigorously controlled, such as randomized clinical trials.

In addition, the potential mechanisms underlying the observed adverse associations between fried foods …
Combination of lentiviral and genome editing technologies for the treatment of sickle cell disease
Authors: Sophie Ramadier, Anne Chalumeau, Tristan Felix, Nadia Othman, Sherazade Aknoun, Antonio Casini, Giulia Maule, Cecile Masson, Anne De Cian, Giacomo Frati, Megane Brusson, Jean-Paul Concordet, Marina Cavazzana, Anna Cereseto, Wassim El Nemer, Mario Amendola, Benoit Wattellier, Vasco Meneghini, Annarita Miccio
Journal: Molecular Therapy (2021)

Sickle cell disease (SCD) is caused by a mutation in the β-globin gene leading to polymerization of the sickle hemoglobin (HbS) and deformation of red blood cells. Autologous transplantation of hematopoietic stem/progenitor cells (HSPCs) genetically modified using lentiviral vectors (LVs) to express an anti-sickling β-globin leads to some clinical benefit in SCD patients, but it requires high-level transgene expression (i.e., high vector copy number [VCN]) to counteract HbS polymerization. Here, we developed therapeutic approaches combining LV-based gene addition and CRISPR-Cas9 strategies aimed to either knock down the sickle β-globin and increase the incorporation of an anti-sickling globin (AS3) in hemoglobin tetramers, or to induce the expression of anti-sickling fetal γ-globins. HSPCs from SCD patients were transduced with LVs expressing AS3 and a guide RNA either targeting the endogenous β-globin gene or regions involved in fetal hemoglobin silencing. Transfection of transduced cells with Cas9 protein resulted in high editing efficiency, elevated levels of anti-sickling hemoglobins, and rescue of the SCD phenotype at a significantly lower VCN compared to the conventional LV-based approach. This versatile platform can improve the efficacy of current gene addition approaches by combining different therapeutic strategies, thus reducing the vector amount required to achieve a therapeutic VCN and the associated genotoxicity risk.
Dual Allergy to Penicillin and Cefazolin—Does Anaphylaxis Matter?
Authors: Boris Mraovic, Noah J. Timko, Tatjana Simurina
Journal: JAMA Surgery (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Fibrin polymer on the surface of biomaterial implants drives the foreign body reaction
Authors: Arnat Balabiyev, Nataly P. Podolnikova, Jacquelyn A. Kilbourne, D. Page Baluch, David Lowry, Azadeh Zare, Robert Ros, Matthew J. Flick, Tatiana P. Ugarova
Journal: Biomaterials (2021)
Biomaterial Wettability Affects Fibrin Clot Structure and Fibrinolysis
Authors: Alexander M. Ruhoff, Jun Ki Hong, Lingzi Gao, Jasneil Singh, Clara Tran, Grace Mackie, Anna Waterhouse
Journal: Advanced Healthcare Materials (2021)

Abstract Thrombosis on blood‐contacting medical devices can cause patient fatalities through device failure and unstable thrombi causing embolism. The effect of material wettability on fibrin network formation, structure, and stability is poorly understood. Under static conditions, fibrin fiber network volume and density increase in clots formed on hydrophilic compared to hydrophobic polystyrene surfaces. This correlates with reduced plasma clotting time and increased factor XIIa (FXIIa) activity. These structural differences are consistent up to 50 µm away from the material surface and are FXIIa dependent. Fibrin forms fibers immediately at the material interface on hydrophilic surfaces but are incompletely formed in the first 5 µm above hydrophobic surfaces. Additionally, fibrin clots on hydrophobic surfaces have increased susceptibility to fibrinolysis compared to clots formed on hydrophilic surfaces. Under low‐flow conditions, clots are still denser on hydrophilic surfaces, but only 5 µm above the surface, showing the combined effect of the surface wettability and coagulation factor dilution with low flow. Overall, wettability affects fibrin fiber formation at material interfaces, which leads to differences in bulk fibrin clot density and susceptibility to fibrinolysis. These findings have implications for thrombus formed in stagnant or low‐flow regions of medical devices and the design of nonthrombogenic materials.
ATRIAL ARRHYTHMIAS ASSOCIATED WITH INCREASED MORBIDITY AND MORTALITY IN PATIENTS HOSPITALIZED WITH COVID-19
Authors: Som Aftabi Bailey, Senthil Thambidorai, Rodney Horton, Andrea Natale, Anand Subramanian, Akhil Gade, Giridhar Mundluru, Sanjeev Nair, Aman Patel, Karan Gupta, Daniel Jipescu
Journal: Journal of the American College of Cardiology (2021)
A novel clip closure method using precutting and a reopenable clip after colorectal endoscopic submucosal dissection
Authors: Masayasu Ohmori, Yasushi Yamasaki, Shumpei Yamamoto, Hideaki Kinugasa, Keita Harada, Sakiko Hiraoka, Hiroyuki Okada
Journal: Endoscopy (2021)

Clip closure of mucosal defects after endoscopic resection has been shown to reduce delayed adverse events [1] [2]; however, closing large defects using a conventional clip can be difficult [1]. Thus, alternative clip closure techniques have been developed, but they still need improvement in terms of simplicity and solderability [3] [4]. We therefore modified an existing precutting technique [4] using a reopenable clip to close large mucosal defects.
Should I take an “F3” year?
Authors: Abi Rimmer
Journal: BMJ (2021)

Should I take an "F3" year?Taking a break between foundation and specialty training offers opportunities to gain experience and work in different areas, Abi Rimmer hears Abi Rimmer It's a chance to stop and reflectHelen Chidera Ota, surgical teaching fellow, says, "For a lot of doctors, an F3 year is the first real 'break' they may have had since entering education.It's very easy to rush through school, university, and foundation training with a focus on jumping through hoops and passing assessments as we go.But time to stop, reflect on what you've experienced, and make thoroughly thought out plans for the future is rare.And that's where an F3 may be useful.
28200 Effects of ruxolitinib cream on work productivity and activity impairment in patients with atopic dermatitis: Pooled results from two phase 3 studies
Authors: Lawrence F. Eichenfield, Jonathan I. Silverberg, Michael E. Kuligowski, May E. Venturanza, Kang Sun, Matthias Augustin
Journal: Journal of the American Academy of Dermatology (2021)
The Genome Sequence Archive Family: Toward Explosive Data Growth and Diverse Data Types
Authors: Tingting Chen, Xu Chen, Sisi Zhang, Junwei Zhu, Bixia Tang, Anke Wang, Lili Dong, Zhewen Zhang, Caixia Yu, Yanling Sun, Lianjiang Chi, Huanxin Chen, Shuang Zhai, Yubin Sun, Li Lan, Xin Zhang, Jingfa Xiao, Yiming Bao, Yanqing Wang, Zhang Zhang, Wenming Zhao
Journal: Genomics Proteomics & Bioinformatics (2021)

The Genome Sequence Archive (GSA) is a data repository for archiving raw sequence data, which provides data storage and sharing services for worldwide scientific communities. Considering explosive data growth with diverse data types, here we present the GSA family by expanding into a set of resources for raw data archive with different purposes, namely, GSA (https://ngdc.cncb.ac.cn/gsa/), GSA for Human (GSA-Human, https://ngdc.cncb.ac.cn/gsa-human/), and Open Archive for Miscellaneous Data (OMIX, https://ngdc.cncb.ac.cn/omix/). Compared with the 2017 version, GSA has been significantly updated in data model, online functionalities, and web interfaces. GSA-Human, as a new partner of GSA, is a data repository specialized in human genetics-related data with controlled access and security. OMIX, as a critical complement to the two resources mentioned above, is an open archive for miscellaneous data. Together, all these resources form a family of resources dedicated to archiving explosive data with diverse types, accepting data submissions from all over the world, and providing free open access to all publicly available data in support of worldwide research activities.
Chlorinated Paraffin Levels in Relation to Other Persistent Organic Pollutants Found in Pooled Human Milk Samples from Primiparous Mothers in 53 Countries
Authors: Kerstin Krätschmer, Rainer Malisch, Walter Vetter
Journal: Environmental Health Perspectives (2021)

The current production and use of chlorinated paraffins (CPs) at >1 million tons/y likely exceeds the lifetime production of polychlorinated biphenyls (PCBs). These persistent organic pollutants (POPs) are a concern to human health.The United Nations Environment Programme conducts global surveys of human milk samples from individual countries as a noninvasive method of investigating levels and trends in human exposures to POPs such as CPs. We measured CP concentrations and assessed their relation to other POPs in pooled samples collected during 2012-2019.We analyzed 57 official nationwide pooled milk samples from 53 countries on five continents (Africa, Central/South America, Asia, Europe, and Australia/Oceania). CP concentrations were further characterized by subgroups and compared with concentrations of 19 other POPs, including PCBs and a variety of pesticides.CPs were detected in pooled samples from all 53 countries, with concentrations of 23-700 ng/g lipid. CPs accounted for 18-46% of the total summed POPs in human milk, second only to dichlorodiphenyltrichloroethane (DDT). CP concentrations exceeded PCB concentrations in pooled samples from most countries.The presence of CPs in all samples, including samples from isolated locations (e.g., Pacific Island countries), emphasizes the ubiquitous presence of these compounds, whereas differences in subgroup ratios indicate a delay in the shift toward nonregulated medium-chain CPs (MCCPs) for these regions. The predominance of MCCPs in samples from many countries suggests a need for regulation and research on health effects. https://doi.org/10.1289/EHP7696.
Neurologic Manifestations and Complications of COVID-19
Authors: Matthew K. Hensley, Desiree Markantone, Hallie C. Prescott
Journal: Annual Review of Medicine (2021)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created a global pandemic. Beyond the well-described respiratory manifestations, SARS-CoV-2 may cause a variety of neurologic complications, including headaches, alteration in taste and smell, encephalopathy, cerebrovascular disease, myopathy, psychiatric diseases, and ocular disorders. Herein we describe SARS-CoV-2's mechanism of neuroinvasion and the epidemiology, outcomes, and treatments for neurologic manifestations of COVID-19.
John Barry Pittard
Authors: Terry McCormack, Henry Purcell
Journal: BMJ (2021)

John Barry Pittard (“JB”) qualified from Magdalen College, Oxford, in 1972, having started his medical education at the University of Newcastle, where he had achieved a first class honours degree in anatomy with a thesis on the duck salt gland. He went on to train in general practice and community medicine, gaining an MSc at the London School of Medicine with a thesis on the epidemiology of cardiac pacing. For most of his career he was a GP in Staines and made headline news in 2014 …
Drug-Resistant Pandemic Influenza Found at Texas Detention Facility
Authors: Bridget M. Kuehn
Journal: JAMA (2021)

Four cases of oseltamivir-resistant 2009 influenza A(H1N1) detected in January 2020 at a US Border Detention Facility in Texas raised concern about the spread of antiviral-resistant strains, according to a study published in Emerging Infectious Diseases.
Angiokines Associated with Targeted Therapy Outcomes in Patients with Non–Clear Cell Renal Cell Carcinoma
Authors: Andrew J. Armstrong, Andrew B. Nixon, Andrea Carmack, Qian Yang, Tim Eisen, Walter M. Stadler, Robert J. Jones, Jorge A. Garcia, Ulka N. Vaishampayan, Joel Picus, Robert E. Hawkins, John D. Hainsworth, Christian K. Kollmannsberger, Theodore F. Logan, Igor Puzanov, Lisa M. Pickering, Christopher W. Ryan, Andrew Protheroe, Daniel J. George, Susan Halabi
Journal: Clinical Cancer Research (2021)

Biomarkers are needed in patients with non-clear cell renal cell carcinomas (NC-RCC) to inform treatment selection but also to identify novel therapeutic targets. We thus sought to profile circulating angiokines in the context of a randomized treatment trial of everolimus versus sunitinib.ASPEN (NCT01108445) was an international, randomized, open-label phase II trial of patients with metastatic papillary, chromophobe, or unclassified NC-RCC with no prior systemic therapy. Patients were randomized to everolimus or sunitinib and treated until disease progression or unacceptable toxicity. The primary endpoint was radiographic progression-free survival (PFS) defined by RECIST 1.1. Plasma angiokines were collected at baseline, cycle 3, and progression and associated with PFS and overall survival (OS).We enrolled 108 patients, 51 received sunitinib and 57 everolimus; of these, 99 patients had evaluable plasma for 23 angiokines. At the final data cutoff, 94 PFS and 64 mortality events had occurred. Angiokines that were independently adversely prognostic for OS were osteopontin (OPN), TIMP-1, thrombospondin-2 (TSP-2), hepatocyte growth factor (HGF), and VCAM-1, and these were also associated with poor-risk disease. Stromal derived factor 1 (SDF-1) was associated with improved survival. OPN was also significantly associated with worse PFS. No statistically significant angiokine-treatment outcome interactions were observed for sunitinib or everolimus. Angiopoeitin-2 (Ang-2), CD-73, HER-3, HGF, IL6, OPN, PIGF, PDGF-AA, PDGF-BB, SDF-1, TGF-b1-b2, TGFb-R3, TIMP-1, TSP-2, VCAM-1, VEGF, and VEGF-R1 levels increased with progression on everolimus, while CD-73, ICAM-1, IL6, OPN, PlGF, SDF-1, TGF-b2, TGFb-R3, TIMP-1, TSP-2, VEGF, VEGF-D, and VCAM-1 increased with progression on sunitinib.In patients with metastatic NC-RCC, we identified several poor prognosis angiokines and immunomodulatory chemokines during treatment with sunitinib or everolimus, particularly OPN.
Dietary Intake of Linoleic Acid, Its Concentrations, and the Risk of Type 2 Diabetes: A Systematic Review and Dose-Response Meta-analysis of Prospective Cohort Studies
Authors: Seyed Mohammad Mousavi, Yahya Jalilpiran, Elmira Karimi, Dagfinn Aune, Bagher Larijani, Dariush Mozaffarian, Walter C. Willett, Ahmad Esmaillzadeh
Journal: Diabetes Care (2021)

Earlier evidence on the association between dietary polyunsaturated fatty acids and risk of diabetes has been conflicting.To quantitatively summarize previous studies on the association between dietary LA intake, its biomarkers, and the risk of type 2 diabetes mellitus (T2DM) in the general population.Our data sources included PubMed/MEDLINE, Scopus, and ISI Web of Science until 24 October 2020; reference lists of all related articles; and key journals.We included prospective cohort studies that examined the associations of linoleic acid (LA) with the risk of T2DM in adults.The inverse variance method was applied to calculate summary relative risk (RR) of LA intake and its biomarkers, and dose-response associations were modeled using restricted cubic splines. Twenty-three publications, covering a total of 31 prospective cohorts, were included; these studies included 297,685 participants (22,639 incident diabetes cases) with dietary intake assessment and 84,171 participants (18,458 incident diabetes cases) with biomarker measurements. High intake of LA was associated with a 6% lower risk of T2DM (summary relative risk [RR] 0.94, 95% CI 0.90, 0.99; I2 = 48.5%). In the dose-response analysis, each 5% increment in energy from LA intake was associated with a 10% lower risk of T2DM. There was also evidence of a linear association between LA intake and diabetes, with the lowest risk at highest intakes. The summary RR for diabetes per SD increment in LA concentrations in adipose tissue/blood compartments was 0.85 (95% CI 0.80, 0.90; I2 = 66.2%). The certainty of the evidence was assessed as moderate.A limitation of our work was the observational design of studies included in the analyses.We found that a high intake of dietary LA and elevated concentrations of LA in the body were both significantly associated with a lower risk of T2DM. These findings support dietary recommendations to consume dietary LA.
Heparin Resistance — Clinical Perspectives and Management Strategies
Authors: Jerrold H. Levy, Jean M. Connors
Journal: New England Journal of Medicine (2021)

Heparin resistance is suspected when more heparin than usual is needed to achieve a therapeutic range of activated partial-thromboplastin time. Management may include increasing the heparin dose, supplementing antithrombin III levels, and using direct thrombin inhibitors.