tbuckley/cabot-search huggingface dataset:
Functional Characterization of Compound <i>DDX41</i> Germline and Somatic R525H Mutations in the Development of Myeloid Malignancies
Authors: Ayana Kon, Masahiro Marshall Nakagawa, Ryosaku Inagaki, Keisuke Kataoka, Hideki Makishima, Yotaro Ochi, Manabu Nakayama, Haruhiko Koseki, Yasuhito Nannya, Seishi Ogawa
Journal: Blood (2020)
Selection of Treatment and Survival in Patients with Gray Zone Lymphoma; A Comprehensive Population-Based Analysis
Authors: Yazan Samhouri, Thejus Jayakrishnan, Lynna Alnimer, Deanna Huffman, Veli Bakalov, Rodney E Wegner, Salman Fazal, Cyrus Kahn, John Lister
Journal: Blood (2020)
Use of Ppmx-T003 As a Potent Inhibitor of Erythrocytosis in Polycythemia Vera
Authors: Nami Masubuchi, Marito Araki, Kaho Shioiri, Sota Kitazawa, Yoshihiko Kihara, Yuta Ohira, Fumiko Nomura, Tadashi Matsuura, Norio Komatsu
Journal: Blood (2020)
SAT0061 The appearance time of periprosthetic bone formations around a cementless titanium stem in total hip arthroplasty is dependent on intramedullary canal fill and shape of proximal femur
Authors: J Saito, H Ohnishi, H Tsurukami, S Akahoshi, S Okabe, N Okimoto, T Nakamura
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> After insertion of cementless stem, new bone formation arise around stem. This bone formation is classified as follows, proximal endosteal bone bridging (spot welds: SW), increased cortical thickness (cortical hypertrophy: CH) and distal intramedullary new bone formation (pedestal: PD) in radiographically. These osteogenesis patterns depend on implant design, material, and mode of porous coating. However, there are no reports concerning about the influence of stem intramedullary canal fill, canal shape, and bone structure of proximal femur on periprosthetic bone remodelling. <h3>Objectives</h3> The purpose of this study was to clarify whether there are relationships between sequential changes of periprosthetic bone remodelling and radiographic variables such as intramedullary canal fill, femoral canal shape, and bone structure. <h3>Methods</h3> Between 1993 and 1998, 57 primary cementless total hip arthroplasties (THAs) were performed with Mallory-Head titanium femoral component in 50 patients of osteoarthritis. The average age at the time of operation was 58 years old. The mean duration of follow-up was 5.2 years. Anteroposterior radiographs of the hip were made at 6 weeks, 3 months, 6 months, 1 year and every year after the operation. We evaluated the frequency and time of new bone remodelling around the stem. Canal shape was converted to numerical value by using calcar to canal isthmus ratio (CC ratio) of Dorr. The large CC ratio indicates a cylindrical shape and the small value reveals funnel shape of proximal femur. Also intamedullary canal fill was measured. Radiographic signs of stem instability were defined as progressive subsidence and radiolucent or radiodense line around the porous coating surface. <h3>Results</h3> SW appeared in all case within a year. At the time of 3 months, proximal canal fill in 40 cases with spot welds was 77% and it was significantly larger than 72% in 17 cases without SW. CH began to appear after 6 months and it was found in 30 cases (53%) after 1 year. PD appeared in 52 cases (91%) after 1 year. The presence rate of SW, CH, and PD at final follow up period did not depend on proximal and distal canal fill. After 6 months, CC ratio of 16 cases with CH was 54% and it was significantly larger than 46% of 41 cases without CH. The appearance of SW and PD did not depend on CC ratio. Radiographic signs of stem instability were not found during follow up period in all cases. <h3>Conclusion</h3> The time of spot welds appearance is earlier in cases with large proximal canal fill. Cortical hypertrophy appeared earlier in cases with cylindrical canal shape rather than funnel shape. However, the appearance rates of new bone formations around cementless stem are not dependent on intramedullary canal fill, shape of proximal femur, and bone structure.
FRI0108 Retinal changes and activity in systemic lupus erythematosus
Authors: Z Hrncir, E Rencova, T Soukup, P Bradna, Z Dvorak
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> The incidence of retinopathy in systemic lupus erythematosus (SLE) and its relation to other clinical and laboratory manifestations of SLE are under debate.<sup>1</sup> Great importance is placed on retinopathy in activity criteria according to the scoring system of SLEDAI.<sup>2</sup> <h3>Objectives</h3> The goal of the monocenter cross sectional study from the East Bohemian region is to clarify the problem according to the incidence of retinal changes of SLE, and evaluation of the disease activity in SLE according to the descriptors of the SLEDAI<sup>2</sup> in patients with and without retinopathy. <h3>Methods</h3> The group under study consists of 60 SLE patients according to ACR classification (1982, updated 1997). One expert ophthalmologist examined the ocular fundi for the presence of retinal changes fulfilling the definition of the SLEDAI descriptor for visual disturbance, but without any information about other SLEDAI descriptors. Data obtained in SLE patients with and without retinopathy were statistically processed using Wilcoxon´s test and Fisher9s exact test. <h3>Results</h3> Retinopathy according to the SLEDAI definition was present in 9 (15%), and absent in 51 (85%) SLE patients. The values of the SLEDAI score in patients with retinopathy were significantly higher than in patients without retinopathy (p &lt; 0.001). In SLE with retinopathy two other SLEDAI descriptors frequency was significantly more than in patients without retinopathy: arthritis (p &lt; 0.035) and increased DNA binding (p &lt; 0.038). <h3>Conclusion</h3> The incidence of retinopathy according to the SLEDAI definition in 15% (9/60) of SLE under study, and significantly higher values of the SLEDAI score in SLE subgroup with retinopathy were found. Data obtained also demonstrated that retinal changes of SLE may be significantly more frequent in SLE with arthritis and with increased DNA binding. <h3>References</h3> Ushiyama O, <i>et al</i>. Ann Rheum Dis. 2000:705–8 Bombardier C, <i>et al</i>. Arthritis Rheum. 1992;35:630–40
Clinical and Biological Impact of <i>TP53</i> Alterations in Del(11q) Chronic Lymphocytic Leukemia
Authors: Claudia Pérez Carretero, Miguel Quijada Álamo, Maria Hernandez-Sanchez, Ana E. Rodriguez, Ana B Herrero, Jesus M Hernández-Sánchez, Marta Martín Izquierdo, Teresa González, Sandra Santos-Mínguez, Cristina Miguel-García, Araceli Rubio-Martínez, Alfonso García de Coca, Julio Dávila, Jose-Angel Hernandez, Rocio Benito, José Luis Ordóñez, Jesus Maria Hernández-Rivas
Journal: Blood (2020)
Progression-Free Survival (PFS) Benefit Demonstrated and Quality of Life (QoL) Maintained across Age and Frailty Subgroups with the Oral Proteasome Inhibitor (PI) Ixazomib Vs Placebo As Post-Induction Maintenance Therapy in Non-Transplant Newly Diagnosed Multiple Myeloma (NDMM) Patients (Pts): Analysis of the TOURMALINE-MM4 Phase 3 Trial
Authors: Sara Bringhen, Luděk Pour, Reuben Benjamin, Sebastian Grosicki, Chang-Ki Min, Danielle Leao Cordeiro De Farias, Alexander Vorog, Richard J Labotka, Bingxia Wang, Dasha Cherepanov, Lauren E. Cain, Sudhakar Manne, S. Vincent Rajkumar, Meletios A. Dimopoulos
Journal: Blood (2020)
Phase 2 Study of Tagraxofusp Therapy for BPDCN Patients Post-Autologous or Post-Allogeneic Hematopoietic Cell Transplantation
Authors: Qaiser Bashir, Katayoun Rezvani, Neeraj Saini, Elizabeth J. Shpall, Samer A. Srour, Uday R. Popat, Denái R. Milton, Naveen Pemmaraju, Richard E. Champlin, Muzaffar H. Qazilbash
Journal: Blood (2020)
<i>TINF2</i> Mutations Are Associated with Poor Outcome Post Hematopoietic Stem Cell Transplantation for Dyskeratosis Congenita
Authors: Yeon Jung Lim, Omri Avraham Arbiv, Melanie Evelyn Kalbfleisch, Mohammed Nuaimi, MacGregor Steele, Geoff D.E. Cuvelier, Tal Schechter-Finkelstein, Bozana Zlateska, Michaela Cada, Yigal Dror
Journal: Blood (2020)
Multi-Disciplinary Obstetrics and Sickle Cell Disease Clinic in Low Resource Setting Lowers Maternal and Perinatal Death Rates to the Same Levels As Those without Sickle Cell Disease
Authors: Samuel A Oppong, Edeghonghon Olayemi, Yvonne Adomakoh, Eugenia Vicky Asare, Enoch Mensah, Alim Swarray-Deen, Yvonne Osei-Bonsu, Selina Crabbe, Latif Musah, Theodore Boafor, Brittany Covert, Adetola A. Kassim, Andra H. James, Mark Rodeghier, Michael R. DeBaun
Journal: Blood (2017)
A Personalized Clinical-Decision Tool to Improve the Diagnostic Accuracy of Myelodysplastic Syndromes
Authors: Nathan Radakovich, Manja Meggendorfer, Luca Malcovati, Mikkael A. Sekeres, Jacob Shreve, Cameron Beau Hilton, Yazan Rouphail, Wencke Walter, Stephan Hutter, Sudipto Mukherjee, Cassandra M. Kerr, Babal K. Jha, Anna Gallì, Sarah Pozzi, Aaron T. Gerds, Cassandra M Kerr, Claudia Haferlach, Jaroslaw P. Maciejewski, Torsten Haferlach, Aziz Nazha
Journal: Blood (2020)
A Shared SF3B1 Neoantigen Is Presented on Primary Malignant Cells and Induced Pluripotent Stem Cell-Derived Hematopoietic Lines
Authors: Melinda Ann Biernacki, Kimberly A Foster, Courtnee Clough, Stephanie Busch, Carrie Cummings, Vivian G. Oehler, Derek Stirewalt, Sergei Doulatov, Marie Bleakley
Journal: Blood (2020)
Abstract 321: Exercise Preconditioning Diminishes Solute Carrier Protein Expression and Cardiac Doxorubicin Accumulation
Authors: Ashley J Smuder, Andres Mor Huertas, Aaron B Morton
Journal: Circulation Research (2020)

Doxorubicin (DOX) is an anthracycline antibiotic used in cancer treatment. Unfortunately, the clinical use of this highly efficacious anticancer drug is limited due to the development of irreversible and dose-dependent cardiomyopathy. While the mechanisms responsible for DOX-induced cardiotoxicity remain unclear, previous work demonstrates that the incidence of cardiac dysfunction greatly correlates to the concentration of DOX transported into the cardiomyocytes. In this regard, we recently demonstrated that endurance exercise performed prior to DOX administration is sufficient to reduce the accumulation of DOX within the heart and prevent left ventricular dysfunction. While the mechanisms for the exercise-induced reduction in cardiac DOX levels are unknown, we hypothesize that endurance exercise alters the expression of solute carrier proteins (SLCs) required for the influx of DOX into the heart. To determine if exercise training can alter SLC protein expression in the heart, animals underwent two weeks of treadmill running (5 days/week; 60 min/day; 30m/min). Twenty-four hours following completion of the exercise training period, animals received either saline or DOX (20mg/kg i.p.) treatment. DOX is a slightly basic cationic compound that is thought to be transported into cells by organic cation transporters. Analysis of the expression of the high affinity organic cation transporters SLC22A4 and SLC22A5 revealed a significant increase in their expression in DOX treated animals, which was mitigated by exercise preconditioning. In addition, the low affinity organic cation transporter SLC22A1 was also increased in DOX treated animals compared to exercise trained animals, while SLC22A3 expression did not differ between groups. Finally, exercise training also reduced the DOX-induced increase in the expression of the mitochondria-localized SLC transporter SLC25A1. These data demonstrate that DOX enhances the expression of several SLCs in the heart, and that exercise may ameliorate cardiac DOX accumulation by preventing the upregulation of proteins with the potential to promote DOX cellular influx.
Post-COVID-19 Epidemic: Allostatic Load among Medical and Nonmedical Workers in China
Authors: Mao Peng, Li Wang, Qing Xue, Lu Yin, Bo-heng Zhu, Kun Wang, Fang-fang Shangguan, Pei-ran Zhang, Yan-yan Niu, Wen-rui Zhang, Wen-feng Zhao, Huang Wang, Jing Lv, Hai-qing Song, Bao-quan Min, Hai-xia Leng, Yu Jia, Hong Chang, Zhi-peng Yu, Qing Tian, Yuan Yang, Zhou Zhu, Wei Li, Xiao-ling Gao, Xiao-lei Liu, Mei Yang, Ping Wang, Peng-hu Wei, Chun-xue Wang, Jin-na Li, Long-bin Jia, Xiao-min Huang, Dong-ning Li, Dong-juan Xu, Yun-long Deng, Tian-mei Si, Hui-qing Dong, Yu-ping Wang, Fiammetta Cosci, Hong-xing Wang
Journal: Psychotherapy and Psychosomatics (2020)

Background: As the fight against the COVID-19 epidemic continues, medical workers may have allostatic load. Objective: During the reopening of society, medical and nonmedical workers were compared in terms of allostatic load. Methods: An online study was performed; 3,590 Chinese subjects were analyzed. Socio-demographic variables, allostatic load, stress, abnormal illness behavior, global well-being, mental status, and social support were assessed. Results: There was no difference in allostatic load in medical workers compared to nonmedical workers (15.8 vs. 17.8%; p = 0.22). Multivariate conditional logistic regression revealed that anxiety (OR = 1.24; 95% CI 1.18–1.31; p &lt; 0.01), depression (OR = 1.23; 95% CI 1.17–1.29; p &lt; 0.01), somatization (OR = 1.20; 95% CI 1.14–1.25; p &lt; 0.01), hostility (OR = 1.24; 95% CI 1.18–1.30; p &lt; 0.01), and abnormal illness behavior (OR = 1.49; 95% CI 1.34–1.66; p &lt; 0.01) were positively associated with allostatic load, while objective support (OR = 0.84; 95% CI 0.78–0.89; p &lt; 0.01), subjective support (OR = 0.84; 95% CI 0.80–0.88; p &lt; 0.01), utilization of support (OR = 0.80; 95% CI 0.72–0.88; p &lt; 0.01), social support (OR = 0.90; 95% CI 0.87–0.93; p &lt; 0.01), and global well-being (OR = 0.30; 95% CI 0.22–0.41; p &lt; 0.01) were negatively associated. Conclusions: In the post-COVID-19 epidemic time, medical and nonmedical workers had similar allostatic load. Psychological distress and abnormal illness behavior were risk factors for it, while social support could relieve it.
<i>IKZF3</i> Overexpression Phenocopies Gain-of-Function Mutation in Chronic Lymphocytic Leukemia
Authors: Shanye Yin, Gregory Lazarian, Elisa Ten Hacken, Tomasz Sewastianik, Satyen Gohil, Shuqiang Li, Laura Z. Rassenti, Leah Billington, Elizabeth Witten, Teddy Huang, Kenneth J. Livak, Donna S. Neuberg, Fanny Baran-Marszak, Thomas J. Kipps, Florence Cymbalista, Ruben D. Carrasco, Catherine J. Wu
Journal: Blood (2020)
Incidence, Management and Outcomes of Arterial and Venous Thromboembolism after Chimeric Antigen Receptor Modified T Cells for B-Cell Lymphoma and Multiple Myeloma
Authors: Anna L. Parks, Swetha Kambhampati, Bita Fakhri, Charalambos Andreadis, Lissa Gray, Sandy W. Wong, Nina Shah, Margaret C. Fang
Journal: Blood (2020)
Nonhuman primates exposed to Zika virus in utero are not protected against reinfection at 1 year postpartum
Authors: Kevin M. Vannella, Sydney Stein, Mark Connelly, Joanna Swerczek, Emerito Amaro-Carambot, Elizabeth M. Coyle, Ashley Babyak, Clayton W. Winkler, Greg Saturday, Neville D. Gai, Dima A. Hammoud, Kimberly A. Dowd, Luis Perez Valencia, Marcos J. Ramos-Benitez, Jason Kindrachuk, Theodore C. Pierson, Karin E. Peterson, Jason M. Brenchley, Steve S. Whitehead, Surender Khurana, Richard Herbert, Daniel S. Chertow
Journal: Science Translational Medicine (2020)

Macaques exposed to Zika virus in utero mount a Zika virus–specific immune response that is not protective against reinfection 1 year after birth.
Impact of particle size and pH on protein corona formation of solid lipid nanoparticles: A proof-of-concept study
Authors: Wenhao Wang, Zhengwei Huang, Yanbei Li, Wenhua Wang, Jiayu Shi, Fangqin Fu, Ying Huang, Xin Pan, Chuanbin Wu
Journal: Acta Pharmaceutica Sinica B (2020)

When nanoparticles were introduced into the biological media, the protein corona would be formed, which endowed the nanoparticles with new bio-identities. Thus, controlling protein corona formation is critical to in vivo therapeutic effect. Controlling the particle size is the most feasible method during design, and the influence of media pH which varies with disease condition is quite important. The impact of particle size and pH on bovine serum albumin (BSA) corona formation of solid lipid nanoparticles (SLNs) was studied here. The BSA corona formation of SLNs with increasing particle size (120–480 nm) in pH 6.0 and 7.4 was investigated. Multiple techniques were employed for visualization study, conformational structure study and mechanism study, etc. "BSA corona-caused aggregation" of SLN2‒3 was revealed in pH 6.0 while the dispersed state of SLNs was maintained in pH 7.4, which significantly affected the secondary structure of BSA and cell uptake of SLNs. The main interaction was driven by van der Waals force plus hydrogen bonding in pH 7.4, while by electrostatic attraction in pH 6.0, and size-dependent adsorption was confirmed. This study provides a systematic insight to the understanding of protein corona formation of SLNs.
Inter and intra-tumor somatostatin receptor 2 heterogeneity influences peptide receptor radionuclide therapy response
Authors: Danny Feijtel, Gabriela N. Doeswijk, Nicole S. Verkaik, Joost C. Haeck, Daniela Chicco, Carmelina Angotti, Mark W. Konijnenberg, Marion de Jong, Julie Nonnekens
Journal: Theranostics (2020)

Patients with neuroendocrine tumors (NETs) can be treated with peptide receptor radionuclide therapy (PRRT). Here, the somatostatin analogue octreotate radiolabeled with lutetium-177 is targeted to NET cells by binding to the somatostatin receptor subtype 2 (SST2). During radioactive decay, DNA damage is induced, leading to NET cell death. Although the therapy proves to be effective, mortality rates remain high. To appropriately select more optimal treatment strategies, it is essential to first better understand the radiobiological responses of tumor cells to PRRT. Methods: We analyzed PRRT induced radiobiological responses in SST2 expressing cells and xenografted mice using SPECT/MRI scanning and histological and molecular analyses. We measured [177Lu]Lu-DOTA-TATE uptake and performed analyses to visualize induction of DNA damage, cell death and other cellular characteristics. Results: The highest accumulation of radioactivity was measured in the tumor and kidneys. PRRT induced DNA damage signaling and repair in a time-dependent manner. We observed intra-tumor heterogeneity of DNA damage and apoptosis, which was not attributed to proliferation or bioavailability. We found a strong correlation between high DNA damage levels and high SST2 expression. PRRT elicited a different therapeutic response between models with different SST2 expression levels. Heterogeneous SST2 expression levels were also confirmed in patient NETs. Conclusion: Heterogeneous SST2 expression levels within NETs cause differentially induced DNA damage levels, influence recurrent tumor phenotypes and impact the therapeutic response in different models and potentially in patients. Our results contribute to a better understanding of PRRT effects, which might impact future therapeutic outcome of NET patients.
Daratumumab (DARA) Plus Lenalidomide, Bortezomib, and Dexamethasone (RVd) in Patients with Transplant-Eligible Newly Diagnosed Multiple Myeloma (NDMM): Updated Analysis of Griffin after 12 Months of Maintenance Therapy
Authors: Jonathan L. Kaufman, Jacob P. Laubach, Douglas Sborov, Brandi Reeves, Cesar Rodriguez, Ajai Chari, Rebecca W. Silbermann, Luciano J. Costa, Larry D. Anderson, Nitya Nathwani, Nina Shah, Yvonne A. Efebera, Sara A. Holstein, Caitlin Costello, Andrzej Jakubowiak, Tanya M. Wildes, Robert Z. Orlowski, Kenneth H. Shain, Andrew J. Cowan, Yana Lutska, Padma Bobba, Huiling Pei, Jon Ukropec, Jessica Vermeulen, Thomas S. Lin, Paul G. Richardson, Peter M. Voorhees
Journal: Blood (2020)
A Systematic Review of Transfusion Transmissible Infections Among Blood Donors and Associated Safety Challenges in Pakistan
Authors: Hamid Ehsan, Ahsan Wahab, Muhammad Ammar Shafqat, Muhammad Khawar Sana, Farhan Khalid, Muhammad Tayyeb, Ahmad Muneeb, Ali Younas Khan, Sajid Ehsan, Amrat Ehsan, Raheel Iftikhar, Faiz Anwer
Journal: Blood (2020)
Maintenance Therapy with Ipilimumab Plus Lenalidomide after Autologous Stem Cell Transplantation for Patients with Lymphoma
Authors: Issa F. Khouri, Denái R. Milton, Celina Ledesma, Elias Jabbour, Qaiser Bashir, Jin S. Im, Luis Fayad, Hun Ju Lee, Ranjit Nair, Loretta J. Nastoupil, Felipe Samaniego, Swami P. Iyer, Christopher Flowers, Richard E. Champlin, Padmanee Sharma, Alison Gulbis
Journal: Blood (2020)
The Quick Antigen Identification By Tissue Flow Cytometry for CAR-T Therapy in Relapsed/Refractory B-Cell Malignancies without Bone Marrow Involvement or Serous Cavity Effusions
Authors: Xinjian Yu, Pan Li, Heyuan Feng, Jian Kang, Xichang Zheng, Yunmei Zhang, Wenhong Yang, Tong Wu, Shuangyou Liu
Journal: Blood (2020)
Preliminary Results of Balli-01: A Phase I Study of UCART22 (allogeneic engineered T-cells expressing anti-CD22 Chimeric Antigen Receptor) in Adult Patients with Relapsed or Refractory (R/R) CD22+ B-Cell Acute Lymphoblastic Leukemia (B-ALL)
Authors: Nitin Jain, Gail J. Roboz, Marina Konopleva, Hongtao Liu, Elias Jabbour, Camille Poirot, Cécile Schiffer-Manniou, Agnès Gouble, Asifa Haider, Oleg Zernovak, Richard A. Larson
Journal: Blood (2020)
Radiation dose and risk of second malignant neoplasms after cancer in childhood: A nested case-control study
Authors: Sylvie Guerin, Catherine Guibout, Akhtar Shamsaldin, Mike Hawkins, Odile Oberlin, Dimitri Lefkopoulos, Florent De Vathaire
Journal: Cancer Research (2005)

1230  Introduction Radiotherapy and chemotherapy are associated with an increasing risk of second malignant neoplasm (SMN). The present case-control study was performed to specify the shape of dose-effect relation, between the local dose of radiation absorbed at the site of the second primary cancer for the case and at the same site for his matched controls and the risk of SMN, all types together. Materials and methods Cases were defined as patients who developed a SMN among 4,581 patients, treated for a solid cancer during childhood, in 8 French and British centres, between 1942 and 1986. In a nested case-control study, each of the 164 cases was matched with 3 controls according to sex, age at the first cancer (± 3 years), calendar year of occurrence of the first cancer (± 4 years), type of first cancer and follow-up. Conditional logistic regression was used to analyse the risk of SMN as a function of radiation and chemotherapy. Results The best dose-effect model was obtained with a linear relation leading to an excess of relative risk per Gray (ERR/Gy) equal to 0.13 (95% CI: 0.06-0.26). ORs associated to local radiation doses varying from 10 Gy to 20 Gy and local radiation doses superior to 20 Gy were respectively equal to 3,1 (95% CI: 1,5-6,6) and 5.1 (95% CI: 2.6-6.1). In the univariate analysis, exposure to chemotherapy coded as yes/no, increased significantly the risk of SMN: OR=2.4 (95% CI: 1.4-4.0). This association remained significant even after adjustment for local dose of radiation OR=2.3 (95% CI: 1.3-4.0). However, no specific association was found between each of the main anti-cancer drug categories and the risk of SMN. No significant interaction was observed between local dose of radiation and chemotherapy or age at diagnosis of FMN or sequence of the combined chemo-radiotherapy approaches. Males exposed to radiotherapy was found to have a higher excess relative risk per gray of developing a second cancer than female, although this result was borderline. Conclusion We conclude that radiation was the most important treatment-related risk factor for the occurrence of a SMN. The lack of effect of a specific drug category such as alkylating agents or spindle inhibitors might result from overmatching criteria, particularly the type of first cancer strongly correlated to the type of treatment.
The Impact of Longitudinal Strain on Haematological and Cardiac Response and Survival in Patients with Systemic AL Amyloidosis
Authors: Oliver C Cohen, Andreia Ismael, Richa Manwani, Sriram Ravichandran, Steven Law, Darren Foard, Ana Martinez-Naharro, Shameem Mahmood, Sajitha Sachchithananthan, Philip N Hawkins, Helen J Lachmann, Julian D Gillmore, Marianna Fontana, Rodney H Falk, Carol Whelan, Ashutosh D. Wechalekar
Journal: Blood (2020)