tbuckley/cabot-search huggingface dataset:
Human neutrophils release serine proteases capable of activating prorenin.
Authors: V JDzau, DGonzalez, CKaempfer, DDubin, B UWintroub
Journal: Circulation Research (1987)

Proteases from human neutrophils can generate angiotensin II directly from angiotensin I or angiotensinogen. We examined whether neutrophil protease also influences angiotensin formation by activating human prorenin (also called inactive renin). When incubated with partially purified plasma and amniotic prorenin, sonicates from 10(6) neutrophils resulted in 120 +/- 30% and 1,240 +/- 290% increase in renin activity, respectively. The pH optimum of neutrophil prorenin-activating enzyme(s) is 6.5-7.0, and the activity of the enzyme(s) is inhibited by a mixture of serine protease inhibitors but not by inhibitors of other proteases, suggesting that prorenin-activating enzyme(s) is a neutral serine protease(s). Stimulation of neutrophils by f-met-leu-phe in the presence of cytochalasin B resulted in release of prorenin-activating enzyme(s) in a dose-dependent fashion. We attempted to isolate prorenin-activating enzyme(s) from neutrophil granules using aprotinin-affinity and carboxymethyl cellulose chromatograph...
“Second Chance” Mechanisms as a First Step to Ending the War on Drugs
Authors: Colleen M. Berryessa
Journal: The American Journal of Bioethics (2021)

In their article “Racial Justice Requires Ending the War on Drugs,” Earp, Lewis, and Hart (2021) argue for the end of our War on Drugs in order to alleviate our reliance on mass incarceration, harm...
Cutaneous mastocytosis in adults with a serum tryptase level &lt; 20 ng mL <sup>–1</sup> : why we should investigate further
Authors: F. Jendoubi, J. Shourick, M. Negretto, C. Laurent, P.A. Apoil, S. Evrard, V. Mansat‐De Mas, M. Severino‐Freire, C. Mailhol, Y. Degboé, P. Dubreuil, O. Hermine, C. Paul, C. Bulai Livideanu
Journal: British Journal of Dermatology (2021)
Participation of adrenergic and noradrenergic neurones in central connections of arterial baroreceptor reflexes in the rat.
Authors: J PChalmers, M APetty, J LReid
Journal: Circulation Research (1979)

We examined activities of tyrosine hydroxylase (TH) and phenylethanolamine-N-methyl transferase (PNMT) and concentrations of norepinephrine (NE) in seven brain regions and the spinal cord of Wistar rats with elevated blood pressures 1 week and 4 weeks after denervation of carotid and aortic baroreceptors, and compared them to values in sham-operated control rats. TH activity was increased in the solitary tract nucleus (to 188% of control), parahypoglossal nucleus (to 254%), locus ceruleus (to 191%), and posterior hypothalamus (to 225%) at 1 week but not at 4 weeks after denervation. Similarly, NE concentrations were significantly altered in a number of brain regions at 1 week but not at 4 weeks after denervation. The only change in NE concentration at 4 weeks was in spinal cord where the level was reduced to 80% of control in the denervated rats. In contrast, the only change in PNMT activity 1 week after denervation was in posterior hypothalamus (to 59% of control), whereas at 4 weeks there was in increas...
Functional dissociation of cellular activation as a mechanism of Mobitz type II atrioventricular block.
Authors: M DGonzalez, B JScherlag, PMabo, RLazzara
Journal: Circulation (1993)

BACKGROUNDSeveral mechanisms have been advanced to explain Mobitz type II atrioventricular block in the ischemically damaged His-Purkinje system. Only recently, however, has an animal model been developed to study this form of conduction defect in vivo and in vitro.METHODS AND RESULTSConduction defects were induced in anesthetized dogs by ischemic damage to the proximal His-Purkinje system after anterior septal artery ligation. Stable 2:1 atrioventricular block, localized within the His bundle or in the proximal bundle branches, was obtained in each dog by atrial pacing at an average rate of 239 +/- 20 beats per minute (n = 12). In vitro studies were then performed from the same hearts. Action potentials and electrograms were simultaneously recorded from the His bundle and the proximal right bundle branch at the site of damage. At slow rates of pacing (40-60 beats per minute), the action potential amplitude was 85 +/- 4 mV, and some cells (10 +/- 3%) showed dissociation from the electrical activity in the...
Guidelines for peripheral percutaneous transluminal angioplasty of the abdominal aorta and lower extremity vessels. A statement for health professionals from a special writing group of the Councils on Cardiovascular Radiology, Arteriosclerosis, Cardio-Thoracic and Vascular Surgery, Clinical Cardiology, and Epidemiology and Prevention, the American Heart Association.
Authors: M JPentecost, M HCriqui, GDorros, JGoldstone, K WJohnston, E CMartin, E JRing, J BSpies
Journal: Circulation (1994)
Effects of alcohol and smoking on blood lead in middle-aged British men
Authors: T Moreau, J Lellouch, G Orssaud, J R Claude, B Juguet, B Festy
Journal: BMJ (1982)

these methods depend at present on electric power to drive centrifuges.The MAEC method has been adapted, not only for rural hospitals but also for field-survey use by the production of complete "kits" of the equipment and materials needed, and has been widely used for field surveys in the Ivory Coast and Uganda, using a small petrol-driven
Early noninvasive detection of successful reperfusion in patients with acute myocardial infarction.
Authors: A KEllis, TLittle, A RMasud, H ALiberman, D CMorris, F JKlocke
Journal: Circulation (1988)

Myoglobin (Mb) is a protein that enters rapidly and is rapidly cleared from plasma after coronary reperfusion. We sought to determine the accuracy with which a rapid rise in plasma [Mb] could predict successful coronary artery reopening in patients undergoing coronary arteriography in conjunction with attempted reperfusion in acute myocardial infarction. In 42 patients, plasma Mb levels were measured before and for at least 4 hours after attempted reperfusion. Thirty-five patients were successfully reperfused. In each, the plasma Mb level rose rapidly with peak [Mb] occurring at 111 +/- 8.1 (+/- SEM) minutes after application of therapy. In contrast, Mb levels rose more slowly in the seven patients who were not reperfused, with peak [Mb] occurring 360 +/- 61.4 minutes after attempted reperfusion. T25-100 (the time required for [Mb] to rise from 25% to 100% of peak value) was shorter in patients successfully reperfused (71 +/- 7.9 minutes) and longer (341 +/- 35.3 minutes) in patients in whom therapy was u...
Inhibition of nitric oxide production. Mechanisms of vascular albumin leakage.
Authors: IKurose, PKubes, RWolf, D CAnderson, JPaulson, MMiyasaka, D NGranger
Journal: Circulation Research (1993)

The mechanisms by which nitric oxide modulates microvascular albumin exchange were investigated by monitoring leukocyte-endothelial cell adhesion and fluorescein isothiocyanate-albumin leakage in rat mesenteric venules exposed to NG-nitro-L-arginine methyl ester (L-NAME). L-NAME elicited an initial rapid increase followed by a slower rate of albumin accumulation in the interstitial space. The initial phase of albumin leakage preceded the L-NAME-induced leukocyte adherence and emigration, whereas the magnitude of the albumin leakage observed in the later phase of L-NAME exposure was highly correlated with the number of adherent and emigrated leukocytes in the same segment of venule. Monoclonal antibodies (MAbs) directed against adhesion molecules CD11/CD18, ICAM-1, or P-selectin, but not a nonbinding MAb, attenuated the albumin leakage induced by L-NAME. WEB2086, a platelet activating factor antagonist, and 8-bromoguanosine 3',5'-cyclic monophosphate (8-br-cGMP) reduced the leukocyte adherence and emigrati...
Soft Tissue Rheumatic Pain. Recognition, Management, Prevention.
Journal: Annals of Internal Medicine (1987)

Introduction - an overview of diagnosis and management pathology the head and neck the upper limb thoraric and chest wall pain disorders lower back pain lower limb disorders fibromyalgia and other generalized soft tissue rheumatic pain disorders physical and occupational therapy nursing care for soft tissue rheumatic pain disorders. Appendices: rheumatology history and physical examination joint protection guide for soft tissue rheumatic pain disorders intralesional soft tissue injection technique coding for your services sources for illustrated equipment.
L-carnitine treatment improves cardiac performance and restores high-energy phosphate pools in cardiomyopathic Syrian hamster.
Authors: J TWhitmer
Journal: Circulation Research (1987)

Hamsters with either the dilated (BIO 53.58) or hypertrophic (BIO 14.6) form of cardiomyopathy and an inbred control strain of hamster (F1B) were treated for 6 months with high-dose L-carnitine (1 g/kg/day i.p.). After treatment, the animals were killed and their hearts perfused by the isolated working technique. Mechanical performance (as indicated by the double product of heart rate and left ventricular [LV] peak systolic pressure) of both carnitine-treated cardiomyopathic groups was increased significantly above their respective sham-treated groups. Associated with these increases in mechanical performance were significant increases in both peak-positive LV dP/dt (index of contractility) and peak negative dP/dt (index of relaxation) in both carnitine-treated myopathic groups. Serum carnitine levels were increased 10-15 times within 2 hours after injection of L-carnitine in all 3 groups. Myocardial free-carnitine levels were increased twofold in both control and dilated myopathic hearts above their resp...
Asynchronous left ventricular diastolic filling in patients with isolated disease of the left anterior descending coronary artery: assessment with radionuclide ventriculography.
Authors: TYamagishi, MOzaki, TKumada, TIkezono, TShimizu, YFurutani, HYamaoka, HOgawa, MMatsuzaki, YMatsuda
Journal: Circulation (1984)

To study the relationship between global and regional filling of the left ventricle, we conducted resting gated radionuclide ventriculographic studies in 15 control subjects (group 1) and 22 patients with isolated disease of the left anterior descending coronary artery (group 2). None had had a previous myocardial infarction. A computer program subdivided the image of the left ventricle into four regions. The time-activity and first-derivative curves of the global and regional left ventricles were computed. In the global left ventricle, the normalized peak filling rate (PFR) was decreased (p less than .01) and the ratio of the time to PFR (time interval from global end-systole to PFR) to the diastolic time, TPFR/DT, was greater (p less than .02) in group 2 than in group 1. In the regional left ventricle, in the side perfused by the stenosed vessel (septal and apical), PFR was slightly decreased in the apical (p less than .05), but not the septal region (p = NS); TPFR/DT was greater in the apical (p less t...
Association of early-onset coronary heart disease in South Asian men with glucose intolerance and hyperinsulinemia.
Authors: P MMcKeigue, J EFerrie, TPierpoint, M GMarmot
Journal: Circulation (1993)

BACKGROUNDRates of coronary heart disease are higher in South Asians (Indians, Pakistanis, and Bangladeshis) settled overseas than in other ethnic groups. We tested the hypothesis that this excess risk results from metabolic disturbances associated with insulin resistance.METHODS AND RESULTSThere were 1,421 South Asian men and 1,515 European men aged 40-69 years in London examined in the Southall Study. Prevalence of ischemic ECG abnormalities was higher in South Asians than in Europeans (17% versus 12%, p < 0.001), with an excess of major Q waves (Minnesota codes 1-1 or 1-2) in younger South Asian men (p = 0.01 for the age-ethnicity interaction). Major Q waves were strongly associated with glucose intolerance and hyperinsulinemia in younger South Asians; these factors accounted statistically for 73% of major Q waves in those aged 40-54 years. Age-standardized prevalence of a positive history of coronary heart disease was similar in South Asians and Europeans (8.5% versus 8.2%, NS), and positive history w...
Allele-specific expression of <i>GATA2</i> due to epigenetic dysregulation in <i>CEBPA</i> double-mutant AML
Authors: Roger Mulet-Lazaro, Stanley van Herk, Claudia Erpelinck, Eric Bindels, Mathijs A. Sanders, Carlo Vermeulen, Ivo Renkens, Peter Valk, Ari M. Melnick, Jeroen de Ridder, Michael Rehli, Claudia Gebhard, Ruud Delwel, Bas J. Wouters
Journal: Blood (2021)
Cardiac trauma from angiographic injections. A quantitative study.
Authors: J AAbbott, M JLipton, JKosek, THayashi, F CLee
Journal: Circulation (1978)

To relate angiographic injections to potential cardiac trauma, we verified a mathematic theory that allows quantitative definition of the kinetic energy content of contrast jets emanating from the exit holes of angiographic catheters. Cineangiographic recordings of a range of jets of known energy content were obtained in 18 cardiac canine experiments and energy content and dissipation were quantified precisely from center line to jet edge. All contrast jets produced in clinical angiographic practice were turbulent, even those from hand injections into the coronary arteries. Energy content was related to an estimated cardiac wall damage threshold. At energy levels and damage thresholds predicted by the theory and computations, a traumatic spectrum was found by cineradiology and microscopic examination. A unique curve independent of jet Reynolds number was discovered relating the penetration of the contrast jet into the intravascular blood to the potential for cardiac trauma. This curve allowed ready calcul...
Reversal of dominance of the coronary arterial system in isolated aortic stenosis and bicuspid aortic valve.
Authors: C BHiggins, LWexler
Journal: Circulation (1975)

The dominance of the coronary arterial system was determined angiographically in 75 adult patients with isolated aortic stenosis with or without insufficiency, 25 adult patients with pure aortic insufficiency, 51 adult patients with combined aortic stenosis and mitral valve disease, and 44 children with bicuspid aortic valves. There was an unusually high incidence of left dominance in adults with isolated aortic stenosis (36%) and in children with bicuspid aortic valves (56.8%). These findings suggest the existence of a variant developmental complex consisting of a bicuspid aortic valve and reversal of dominance of the coronary arterial system. Furthermore, it adds support to the concept that progressive stenosis of a bicuspid aortic valve is frequently the etiology of isolated aortic stenosis in adults.
Early and late results of surgical repair of truncus arteriosus.
Authors: CMarcelletti, D CMcGoon, G KDanielson, R BWallace, D DMair
Journal: Circulation (1977)

Ninety-two patients had corrective operation for truncus arteriosus between 1967 and 1975. During the first 30 days after surgery, 23 patients died. No significant differences appear between early mortality and sex, type of truncus, variations in pulmonary arterial anatomy, truncal valve regurgitation, associated anomalies, previous operation, or duration of extracorporeal circulation. Greater risk is probably encountered with the higher but still operable levels of pulmonary resistance. Reoperation has been required in three patients. Fifty-nine percent of survivors are symptom-free, with all but two of the remainder (38%) being in NYHA functional class II. The late result is suggestively less satisfactory in patients with significant preoperative truncal valve regurgitation. Some late complications related to deterioration of the earlier aortic homograft conduit may be avoided by use of a porcine valve Dacron conduit. The current operative mortality of 9%, and the well-being of 97% of surviving patients...
OCEANS: プラチナ感受性再発上皮性卵巣癌,原発性腹膜癌またはファロピウス管癌患者におけるベバシズマブの有無に関わらない化学療法の無作為化,二重盲検,プラセボ対照第III相試験
Authors: Aghajanian Carol, V Blank Stephanie, A Goff Barbara, L Judson Patricia, G Teneriello Michael, Husain Amreen, A Sovak Mika, Yi Jing, R Nycum Lawrence
Journal: Journal of Clinical Oncology (2012)
Treatment Of Duodenal Ulcer Bleeding - Efficacy Of Traumatic and Atraumatic Over-The-Scope-Clips (OTSC) – A Multicenter Retrospective Analysis
Authors: M Hollenbach, A Schmidt, A Decker, O Möschler, C Jung, N Mechie, T Barhoom, A Hegelein, R Knoop, T Blasberg, E Wedi
Journal: Endoscopy (2021)

Aims The over-the-scope-clip (OTSC) substantially improved the endoscopic armamentarium for the treatment of severe gastrointestinal bleeding and can potentially overcome limitations of standard clips. Recent data indicated superiority of OTSC in hemostasis as first and second line therapy. However, the impact of the OTSC design (traumatic (-t) or atraumatic (-a) type) in particular in duodenal ulcer bleeding has not been analyzed thus far.
The additive antianginal action of oral nifedipine in patients receiving propranolol: magnitude and duration of effect.
Authors: MBassan, DWeiler-Ravell, OShalev
Journal: Circulation (1982)

Ten men with stable angina not completely relieved by full doses of propranolol (mean 218 mg/day) were administered an oral dose of 10 mg of nifedipine or placebo on alternate mornings in a double-blind fashion. Patients had been trained in a protocol that precipitated angina after 3-6 minutes of bicycle exercise. On test days, with propranolol continued, bicycle exercise to angina or fatigue was performed before nifedipine or placebo administration, and hourly thereafter for 8 hours. Mean exercise duration was greater 1 hour after nifedipine than after placebo by 123 seconds (372 +/- 21 vs 249 +/- 16 seconds, p less than 0.001). By the fifth hour, the increase in exercise time was reduced to 93 seconds (p less than 0.001), and a significant, though further diminished, difference of 57 seconds was still present at 8 hours (p less than 0.01). Nifedipine lowered resting systolic blood pressure by 20 mm Hg (p less than 0.001) without appreciably changing heart rate. We conclude that nifedipine is a very effe...
Cytomegalovirus in Patients in the Intensive Care Unit
Authors: Gerardo Aguilar, David Navarro
Journal: JAMA Internal Medicine (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Diagnosis And Endoscopic Removal of Gossypiboma From Suprahepatic Space: A Case Report
Authors: A Stupnytskyy, H Hula, N Stupnytska, P Shevyak
Journal: Endoscopy (2021)

Aims The aim is to present the case of gossypiboma of the suprahepatic space and own experience of its endoscopic removal. In the analysis of the medical literature, we did not find reports of endoscopic treatment of such retained foreign bodies (RFBs).
Microvascular effects of atrial natriuretic factor: interaction with alpha 1- and alpha 2-adrenoceptors.
Authors: J EFaber, D RGettes, D PGianturco
Journal: Circulation Research (1988)

The cremaster skeletal muscle of anesthetized rats was denervated and extended with intact circulation into a tissue bath. Intravital microscopy was used to measure microvessel diameter at three different anatomical levels within the microcirculation: large distributing arterioles (x control diameter = 100 +/- 7 micron), large capacitance venules (147 +/- 8 micron), and small terminal arterioles (17 +/- 1 micron). Norepinephrine (NE) was added to the cremaster bath to produce intermediate reductions in diameter of large arterioles and venules (55% and 38% of maximum constriction, respectively). In the presence of NE tone, bath-added atrial natriuretic factor (ANF) produced concentration-dependent dilation of both arterioles and venules. Arteriolar IC25 = 18 pmol and IC50 = 1.2 X 10(-10) M; venules exhibited similar sensitivity. However, the highest ANF concentration examined (10(-7) M) only reversed NE-induced tone by 70%. In a second large vessel group ANF completely reversed constriction induced by the ...
Hydration status, body composition, and anxiety status in aeronautical military personnel from Spain: a cross-sectional study
Authors: Alejandra Carretero-Krug, Natalia Úbeda, Carlos Velasco, Juan Medina-Font, Trinidad Trujillo Laguna, Gregorio Varela-Moreiras, Ana Montero
Journal: Military Medical Research (2021)

An adequate hydration status is critical to ensure efficiency during mental and physical activities. Our goal was to assess the hydration status of a Spanish group of aeronautical military men and to determine the association of hydration status with body composition and anxiety.
Diagnosis of hookworm disease
Authors: H. De la Riva
Journal: JAMA (1982)

To the Editor.—  This is in reply to the letter by Drs McIntyre and Keystone(1982;247:1565) regarding our previously published article (1981; 246:68).  The egg count per gram of feces is a well-known method for estimating the intensity of worm infection, because it reflects the number of worms parasiting the host. In the reported case we did not have fecal egg counts because it is not a routine procedure at our hospital, but possibly it is not necessary because the jejunal mucous membrane was completely covered by hookworms (probably many thousands). The prothrombin, thrombin, and partial thromboplastin times, as well as the platelet count and fibrinogen level, were normal. There was no previous alcohol or other drug (including aspirin) intake in our patient. We agree that the patient might have had a mononucleosis-like illness, although the Paul Bunnel test result was negative, the liver biopsy specimen did not show cytomegalovirus inclusions,
Cell calcium in the pathophysiology of ventricular fibrillation and in the pathogenesis of postarrhythmic contractile dysfunction.
Authors: YKoretsune, EMarban
Journal: Circulation (1989)

The mechanism of ventricular fibrillation is poorly understood at the cellular level. We explored the role of intracellular free calcium in the pathophysiology and pathogenesis of ventricular fibrillation in perfused ferret hearts loaded with the Ca2+ indicator 5F-BAPTA. Nuclear magnetic resonance spectroscopy was used to measure [Ca2+]i, pH, and high-energy phosphates. During ventricular fibrillation induced by burst pacing, [Ca2+]i rose rapidly and dramatically, exceeding by four times the control within 5 minutes. [Ca2+]i remained markedly elevated throughout 20 minutes of fibrillation, but it returned to control values shortly after defibrillation. In a group of hearts kept isovolumic by a balloon in the left ventricle, acidosis and high-energy phosphate depletion developed despite the maintenance of normal coronary pressure. To distinguish the effects of superimposed ischemia from those of the arrhythmia itself, we lowered left ventricular volume during fibrillation in a second group of hearts. This ...