tbuckley/cabot-search huggingface dataset:
Newer tests for the diagnosis of renovascular disease
Authors: R. A. Davidson
Journal: JAMA (1992)

<h3>Objective.</h3> —To evaluate published reports of diagnostic methods for renovascular hypertension, including Doppler ultrasonography, magnetic resonance imaging, the captopril test, and captopril scanning. <h3>Data Sources.</h3> —MEDLINE and selected references from appropriate published articles. <h3>Study Selection.</h3> —Studies included those that calculated sensitivities and specificities; studies that derived diagnostic criteria without application to another population of patients were excluded. Consensus of both authors was necessary for inclusion. <h3>Data Extraction.</h3> —Articles were critically assessed independently by the authors and a consensus critique was developed. <h3>Data Synthesis.</h3> —Major sources of variability exist in the investigations of recently developed tests for renovascular hypertension. These include variability in patient populations, performance of tests, and determination of outcome measures. <h3>Conclusions.</h3> —Among the newer diagnostic tests, both magnetic resonance imaging and Doppler ultrasonography hold promise for the anatomic detection of renal artery stenosis, but clear diagnostic criteria have not been universally accepted. There is more information concerning the captopril test, which has a sufficiently high sensitivity to be useful in the screening of high-risk patients for renovascular hypertension. Scans after captopril administration, which appear to be more specific, may enable the prediction of a blood pressure response to angioplasty or surgery. (<i>JAMA</i>. 1992;268:3353-3358)
Anatomy of the Duodenal Papilla and Genesis of Pancreatic Reflux
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Milk and Its Products.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Handbook of Operative Surgery: Surgery of the Chest.
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Metabolism and effect of 7-oxo-lithocholic acid 3-sulfate on bile flow and biliary lipid secretion in rats
Authors: H Yamashita
Journal: Hepatology (1994)

Significant amounts of oxo and sulfated bile acids are excreted in the urine of patients with cholestatic liver diseases, but these bile acid species are found only in traces in bile. Several possible explanations for this finding include poor canalicular secretion, rapid biotransformation by oxidoreduction and extrahepatic sulfation of oxo bile acids. To assess the physiological actions and hepatic metabolism of oxo and sulfated bile acids, we synthesized 7-oxo-lithocholic acid 3-sulfate, examined the effect of intravenous infusion of this bile acid (5.0 μmol/min/kg body wt) on bile flow and biliary lipid secretion in Sprague-Dawley rats with a bile fistula and compared this effect with that of the unconjugated analog, 7-oxo-lithocholic acid, and the primary bile acid conjugate, chenodeoxycholic acid 3-sulfate. Bile flow and bile acid secretion increased immediately after infusion of all three bile acids. The highly polar 7-oxo-lithocholic acid 3-sulfate significantly reduced the biliary secretion of phospholipids (p < 0.05) and cholesterol (p < 0.05), but by contrast the more hydrophobic analog, 7-oxo-lithocholic acid, caused a significant increase in the biliary phospholipids (p < 0.01) and cholesterol (p < 0.01) secretion. Infusion of chenodeoxycholic acid 3-sulfate also resulted in an increase in secretion of biliary cholesterol and phospholipids, but the magnitude of the change was less than that induced by 7-oxo-lithocholic acid infusion. Biliary lipid secretion was inversely related to the polarity of the infused bile acid. Negative ion fast atom bombardment—mass spectrometry and gas chromatography—mass spectrometry analyses indicated that the major bile acids excreted in the bile after infusion of 7-oxo-lithocholic acid were taurine and glycine conjugates of the parent compound and the corresponding conjugates of its metabolite, ursodeoxycholate, whereas chenodeoxycholate and its conjugates were minor metabolites. By contrast, 7-oxo-lithocholic acid 3-sulfate and chenodeoxycholic acid 3-sulfate were only partially amidated with taurine and glycine and did not undergo further metabolic transformation of the steroid nucleus. These data demonstrate that sulfation of 7-oxo-lithocholic acid significantly alters its physiological properties and hinders biotransformation, including oxidoreduction, hydroxylation and amidation. The findings that the sulfate conjugates of 7-oxo-lithocholic acid and chenodeoxycholic acid are efficiently and preferentially secreted into bile, and not into urine, would strongly indicate that the bile acid sulfates, found in relatively high proportions in the urine of patients with cholestasis, are of extrahepatic and most probably of renal origin.
VIENNA
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neuroleptic malignant syndrome. Successful treatment with pancuronium
Authors: R. Sangal
Journal: JAMA (1985)

NEUROLEPTICS are useful medicines widely used to control psychosis and agitation. They have numerous side effects, including little-understood ones such as tardive dyskinesia and neuroleptic malignant syndrome (NMS). The latter is a rare side effect of most neuroleptics, including haloperidol, fluphenazine decanoate, and chlorpromazine. The occurrence of NMS does not seem to be related to dose or drug interactions. It is more likely to occur in young men, patients with brain disorders, and persons treated with depot-injection preparations, while heat stress, physical exhaustion, or dehydration may predispose to the syndrome.<sup>1-3</sup>Findings include hyperpyrexia, rigidity, dysphagia, dyskinesia, akinesia, delirium, sialorrhea, tachypnea-dyspnea, tachycardia, labile hypertension, cardiac arrhythmias, elevation in creatine kinase and liver function values, and respiratory acidosis.<sup>3</sup>Death rates range from 20% to 38%, and death may occur because of complications such as cardiac arrhythmias, myocardial infarction, thromboembolism, aspiration pneumonia, respiratory failure, and rhabdomyolysis with myoglobinuria and acute renal
Are "America's Best Hospitals" America's Best?
Authors: Peter G. Goldschmidt
Journal: JAMA (1997)

<h3>To the Editor.</h3> —In their timely and creative article, Dr Green and colleagues once again draw our attention to the serious paucity of meaningful assessments of the quality of hospital care—specifically, the dearth of systems to assess care processes—and the lack of effort devoted to them.<sup>1</sup>Almost 150 years ago, Florence Nightingale understood the principles necessary to measure the quality of hospital care.<sup>2</sup>Almost 100 years ago, Codman pointed out that the lack of incentives to assess quality results in the lack of quality assessments.<sup>3</sup>They lacked the technology to validly assess the quality of care. Today, the necessary computer-based technology exists, and its application at little cost will become routine when electronic medical records become the norm. Practical quality assessment and quality improvement depend on comparing care processes that should have been applied to improve a particular patient's health status (a global measure of the health quality of life)
Marriages
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
International Comments
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Half Century of Public Health. Jubilee Historical Volume of the American Public Health Association in Commemoration of the Fiftieth Anniversary Celebration of Its Foundation.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The growth inhibitory effects of vitamins K and their actions on gene expression*1
Authors: Z WANG
Journal: Hepatology (1995)

A characteristic defect occurs in rat and human hepatocellular carcinoma (HCC) resulting in a loss of function of the vitamin K-dependent enzyme gamma-glutamyl-carboxylase in the tumor but not in the underlying liver. This causes the secretion of elevated levels of the immature or des-gamma-carboxylated form of prothrombin, which is used as a marker of HCC. We investigated whether, using the defined conditions of growing HCC cell lines in tissue culture, addition of the naturally occurring vitamins K1 or K2 or the synthetic vitamin K3 could influence the secretion of immature prothrombin. We found that vitamins K1, K2, and K3 all suppressed the secretion of immature prothrombin into the tissue culture medium. Vitamins K2 and K3 were also found to inhibit growth of the HCC cell line, in an apparently nontoxic and reversible manner. The influence of the vitamins K on the expression of some genes related to vitamin K action was examined and compared with that of another growth inhibitor, TGFβ1 protein. The vitamins K were found to increase the expression of prothrombin and carboxylase messenger RNA and c-myc messenger RNA, but had no effects on the expression of TGFβ1 messenger RNA. By contrast, TGFβ1 increased TGF/β1 messenger RNA levels, but had no effects on the other genes, suggesting a different pathway. The previously studied vitamin K3-mediated inhibition of growth was antagonized by the addition of catalase to the culture medium, but the inhibitory effects of vitamin K2 were not antagonized. These experiments show that the vitamins K are a class of growth inhibitors that have a novel mechanism, possibly involving carboxylation.
Prognostic role of plasma chromogranin A levels in prostate cancer patients with hormone refractory disease
Authors: A. Mosca, A. Berruti, M. Tucci, F. Vana, R. Bitossi, C. Cracco, M. Torta, M. Poggio, R. M. Scarpa, L. Dogliotti
Journal: Journal of Clinical Oncology (2004)

9563 Background: neuroendocrine (NE) differentiation in prostate cancer (PC) is more frequently expressed in hormone refractory patients than in those with hormone naive disease. Chromogranin A (CgA) is the most employed marker to detect NE features. Methods: plasma CgA (ELISA kit, DAKO, Glostrup-Denmark, reference range in PC patients 2–20 U/L) was evaluated at baseline conditions in 108 consecutive patients with hormone refractory PC. Results: patients characteristics were as follows: median age 74 yrs (range 58–86), median ECOG performance status 1 (range 0–3). 105 patients (97.2%) had metastatic bone disease, 91 patients (84,2%) had elevated PSA values (median 97.0 ng/ml, range 0.1–3393.0). Median CgA values was 17.3 U/L (range 3.0–394.0), supranormal CgA values were recorded in 45 patients (43.3%). Baseline elevated plasma CgA correlated with a shorter survival perspect: 11.13 months (range: 3.5–18.7) vs 22.37 months (range: 13.7–31.0) (p=0.02). In a multivariate analysis, plasma CgA provided independent prognostic information [Hazard Risk 1.28 (95% Confidence interval 1.08–1.53), p<0.005] with respect to serum PSA [Hazard Risk 1.10 (95% Confidence Interval 1.02–1.19), p=0.01]. Plasma CgA was prospectively evaluated after 3, 6, and 9 months in 50 patients submitted to chemotherapy. Median CgA plasma levels (range) were: 13.3 U/l (3.0–141.0) at baseline and 19.1 (3.0–486.0), 20.8 (3.0–702.0) and 39.4 (3.0–414.0) after 3, 6 and 9 months, respectively (p<0.01); the corresponding supranormal rates were 17/50 (34%), 23/50 (46%), 26/50 (52%) and 34/50 (68%) (p<0.005). Conclusions: elevated plasma CgA is frequently observed in PC patients with hormone refractory disease and correlates with poor prognosis. The prognostic role of plasma CgA is independent to that of serum PSA. Plasma CgA values show a progressive increase during chemotherapy, suggesting that NE phenotype expression in hormone refractory PC patients is a time-dependent phenomenon and is not influenced by the cytotoxic treatment. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration DAKO Glostrup Denmark
POSSIBLE INVASION OF THE ENDOMETRIUM BY SPIROCHETES
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEWS
Authors: L. MILAS
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article BOOK REVIEWS Get access Eicosanoids and Radiation Peter Polgar, ed. Dordrecht, The Netherlands: Martinus Nijhoff Publishers, 1988; 208pp. $62.50. LUKA MILAS LUKA MILAS Department of Experimental Radiotherapy, The University of Texas, M. D. Anderson Cancer Center1515 Holcombe Blvd. Houston, TX 77030 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 1, January 1989, Page 69, https://doi.org/10.1093/jnci/81.1.69 Published: 01 January 1989
Outcomes of Treatment vs Observation of Localized Prostate Cancer in Elderly Men
Authors: Grace L. Lu-Yao, Michael J. Barry, Peter C. Albertsen, Siu-Long Yao
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal