tbuckley/cabot-search huggingface dataset:
Racial and Ethnic Disparities in Home Dialysis Use in the United States: Barriers and Solutions
Authors: Katherine Rizzolo, Lilia Cervantes, Jenny I. Shen
Journal: Journal of the American Society of Nephrology (2022)

In 2019, the Advancing American Kidney Health (AAKH) Executive Order set a goal: by 2025, 80% of patients with incident kidney failure should be started on home dialysis therapies, or receive a kidney transplant. Racial and ethnic minority populations have a disproportionately high risk of kidney
Motorized spiral enteroscopy: results of an international multicenter prospective observational clinical study in patients with normal and altered gastrointestinal anatomy
Authors: Torsten Beyna, Tom Moreels, Marianna Arvanitakis, Mathieu Pioche, Jean-Christophe Saurin, Andrea May, Mate Knabe, Jørgen Steen Agnholt, Niels Christian Bjerregaard, Lauri Puustinen, Christoph Schlag, Lars Aabakken, Vemund Paulsen, Markus Schneider, Markus F. Neurath, Timo Rath, Jacques Devière, Horst Neuhaus
Journal: Endoscopy (2022)

Abstract Background Motorized spiral enteroscopy (MSE) has been shown to be safe and effective for deep enteroscopy in studies performed at expert centers with limited numbers of patients without previous abdominal surgery. This study aimed to investigate the safety, efficacy, and learning curve associated with MSE in a real-life scenario, with the inclusion of patients after abdominal surgery and with altered anatomy. Methods Patients with indications for deep enteroscopy were enrolled in a prospective observational multicenter study. The primary objective was the serious adverse event (SAE) rate; secondary objectives were the diagnostic and therapeutic yield, procedural success, time, and insertion depth. Data analysis was subdivided into training and core (post-training) study phases at centers with different levels of MSE experience. Results 298 patients (120 women; median age 68, range 19–92) were enrolled. In the post-training phase, 21.5 % (n = 54) had previous abdominal surgery, 10.0 % (n = 25) had surgically altered anatomy. Overall, SAEs occurred in 2.3 % (7/298; 95 %CI 0.9 %–4.8 %). The SAE rate was 2.0 % (5/251) in the core group and 4.3 % (2/47) in the training group, and was not increased after abdominal surgery (1.9 %). Total enteroscopy was achieved in half of the patients (n = 42) undergoing planned total enteroscopy. In 295/337 procedures (87.5 %), the anatomical region of interest could be reached. Conclusions This prospective multicenter study showed that MSE was feasible and safe in a large cohort of patients in a real-life setting, after a short learning curve. MSE was shown to be feasible in postsurgical patients, including those with altered anatomy, without an increase in the SAE rate.
Policies and Practices to Address Cancer’s Long-Term Adverse Consequences
Authors: Cathy J Bradley, Sara Kitchen, Smita Bhatia, Julie Bynum, Gwen Darien, J Leonard Lichtenfeld, Randall Oyer, Lawrence N Shulman, Lisa Kennedy Sheldon
Journal: JNCI Journal of the National Cancer Institute (2022)

As cancer detection and treatment improve, the number of long-term survivors will continue to grow, as will the need to improve their survivorship experience and health outcomes. We need to better understand cancer and its treatment's short- and long-term adverse consequences and to prevent, detect, and treat these consequences effectively. Delivering care through a collaborative care model; standardizing information offered to and collected from patients; standardizing approaches to documenting, treating, and reducing adverse effects; and creating a data infrastructure to make population-based information widely available are all actions that can improve survivors' outcomes. National policies that address gaps in insurance coverage, the cost and value of treatment and survivorship care, and worker benefits such as paid sick leave can also concurrently reduce cancer burden. The National Cancer Policy Forum and the Forum on Aging, Disability, and Independence at the National Academies of Sciences, Engineering, and Medicine sponsored a virtual workshop on "Addressing the Adverse Consequences of Cancer Treatment," November 9-10, 2020, to examine long-term adverse consequences of cancer treatment and to identify practices and policies to reduce treatment's negative impact on survivors. This commentary discusses high-priority issues raised during the workshop and offers a path forward.
General anesthesia globally synchronizes activity selectively in layer 5 cortical pyramidal neurons
Authors: Arjun Bharioke, Martin Munz, Alexandra Brignall, Georg Kosche, Max Ferdinand Eizinger, Nicole Ledergerber, Daniel Hillier, Brigitte Gross-Scherf, Karl-Klaus Conzelmann, Emilie Macé, Botond Roska
Journal: Neuron (2022)

General anesthetics induce loss of consciousness, a global change in behavior. However, a corresponding global change in activity in the context of defined cortical cell types has not been identified. Here, we show that spontaneous activity of mouse layer 5 pyramidal neurons, but of no other cortical cell type, becomes consistently synchronized in vivo by different general anesthetics. This heightened neuronal synchrony is aperiodic, present across large distances, and absent in cortical neurons presynaptic to layer 5 pyramidal neurons. During the transition to and from anesthesia, changes in synchrony in layer 5 coincide with the loss and recovery of consciousness. Activity within both apical and basal dendrites is synchronous, but only basal dendrites' activity is temporally locked to somatic activity. Given that layer 5 is a major cortical output, our results suggest that brain-wide synchrony in layer 5 pyramidal neurons may contribute to the loss of consciousness during general anesthesia.
In situ synthesis and unidirectional insertion of membrane proteins in liposome-immobilized silica stationary phase for rapid preparation of microaffinity chromatography
Authors: Yanqiu Gu, Rong Wang, Panpan Chen, Shengnan Li, Xinyi Chai, Chun Chen, Yue Liu, Yan Cao, Diya Lv, Zhanying Hong, Zhenyu Zhu, Yifeng Chai, Yongfang Yuan, Xiaofei Chen
Journal: Acta Pharmaceutica Sinica B (2022)

Cell membrane affinity chromatography has been widely applied in membrane protein (MP)-targeted drug screening and interaction analysis. However, in current methods, the MP sources are derived from cell lines or recombinant protein expression, which are time-consuming for cell culture or purification, and also difficult to ensure the purity and consistent orientation of MPs in the chromatographic stationary phase. In this study, a novel in situ synthesis membrane protein affinity chromatography (iSMAC) method was developed utilizing cell-free protein expression (CFE) and covalent immobilized affinity chromatography, which achieved efficient in situ synthesis and unidirectional insertion of MPs into liposomes in the stationary phase. The advantages of iSMAC are: 1) There is no need to culture cells or prepare recombinant proteins; 2) Specific and purified MPs with stable and controllable content can be obtained within 2 h; 3) MPs maintain the transmembrane structure and a consistent orientation in the chromatographic stationary phase; 4) The flexible and personalized construction of cDNAs makes it possible to analyze drug binding sites. iSMAC was successfully applied to screen PDGFRβ inhibitors from Salvia miltiorrhiza and Schisandra chinensis. Micro columns prepared by in-situ synthesis maintain satisfactory analysis activity within 72 h. Two new PDGFRβ inhibitors, salvianolic acid B and gomisin D, were screened out with KD values of 13.44 and 7.39 μmol/L, respectively. In vitro experiments confirmed that the two compounds decreased α-SMA and collagen Ӏ mRNA levels raised by TGF-β in HSC-T6 cells through regulating the phosphorylation of p38, AKT and ERK. In vivo, Sal B could also attenuate CCl4-induced liver fibrosis by downregulating PDGFRβ downstream related protein levels. The iSMAC method can be applied to other general MPs, and provides a practical approach for the rapid preparation of MP-immobilized or other biological solid-phase materials.
Risk of hospitalisation associated with infection with SARS-CoV-2 omicron variant versus delta variant in Denmark: an observational cohort study
Authors: Peter Bager, Jan Wohlfahrt, Samir Bhatt, Marc Stegger, Rebecca Legarth, Camilla Holten Møller, Robert Leo Skov, Palle Valentiner-Branth, Marianne Voldstedlund, Thea K Fischer, Lone Simonsen, Nikolai Søren Kirkby, Marianne Kragh Thomsen, Katja Spiess, Ellinor Marving, Nicolai Balle Larsen, Troels Lillebaek, Henrik Ullum, Kåre Mølbak, Tyra Grove Krause, Sofie Marie Edslev, Raphael Niklaus Sieber, Anna Cäcilia Ingham, Maria Overvad, Mie Agermose Gram, Frederikke Kristensen Lomholt, Louise Hallundbæk, Caroline Hjorth Espensen, Sophie Gubbels, Marianne Karakis, Karina Lauenborg Møller, Stefan Schytte Olsen, Zitta Barrella Harboe, Caroline Klint Johannesen, Maarten van Wijhe, Jon Gitz Holler, Ram Benny Christian Dessau, Martin Barfred Friis, David Fuglsang-Damgaard, Mette Pinholt, Thomas Vognbjerg Sydenham, John Eugenio Coia, Ea Sofie Marmolin, Anders Fomsgaard, Jannik Fonager, Morten Rasmussen, Arieh Cohen
Journal: The Lancet Infectious Diseases (2022)
Re: Post-COVID-19 syndrome and humoral response association after one year in vaccinated and unvaccinated patients by Peghin et al.
Authors: Pathum Sookaromdee, Viroj Wiwanitkit
Journal: Clinical Microbiology and Infection (2022)

We would like to share ideas on the publication "Post-COVID-19 syndrome and humoral response association after one year in vaccinated and unvaccinated patients [1]." Peghin et al. stated that their findings support the routine administration of three mRNA vaccine doses to adolescents and young adults [1]. Over a year after acute infection, the SARS-CoV-2 immunization is not linked to the appearance of post–COVID-19 symptoms [1]. The persistence of strong serological titres responses caused by spontaneous infection but not by vaccination, according to Peghin et al., may play a role in long COVID-19 [1].
Predicting peritoneal recurrence and disease-free survival from CT images in gastric cancer with multitask deep learning: a retrospective study
Authors: Yuming Jiang, Zhicheng Zhang, Qingyu Yuan, Wei Wang, Hongyu Wang, Tuanjie Li, Weicai Huang, Jingjing Xie, Chuanli Chen, Zepang Sun, Jiang Yu, Yikai Xu, George A Poultsides, Lei Xing, Zhiwei Zhou, Guoxin Li, Ruijiang Li
Journal: The Lancet Digital Health (2022)
Psychopharmacologic Considerations for Transgender and Gender Diverse People
Authors: Jack L. Turban, Marija Kamceva, Alex S. Keuroghlian
Journal: JAMA Psychiatry (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Recent patents in allergy and immunology: Method for treating asthma or allergic disease via anti‐Notch4 mAb
Authors: Hani Harb, Talal A. Chatila
Journal: Allergy (2022)

H.H. and T.A.C. are scientific co-founders and stockholders in Alcea Therapeutics. H.H. serves as an interim Chief Scientific Officer of Alcea Therapeutics.
Flagellate Mushroom Dermatitis
Authors: Jade N. Young, May Elgash
Journal: JAMA Dermatology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Comprehensive cross-sectional and longitudinal analyses of plasma neurofilament light across FTD spectrum disorders
Authors: Tania F. Gendron, Michael G. Heckman, Launia J. White, Austin M. Veire, Otto Pedraza, Alexander R. Burch, Andrea C. Bozoki, Bradford C. Dickerson, Kimiko Domoto-Reilly, Tatiana Foroud, Leah K. Forsberg, Douglas R. Galasko, Nupur Ghoshal, Neill R. Graff-Radford, Murray Grossman, Hilary W. Heuer, Edward D. Huey, Ging-Yuek R. Hsiung, David J. Irwin, Daniel I. Kaufer, Gabriel C. Leger, Irene Litvan, Joseph C. Masdeu, Mario F. Mendez, Chiadi U. Onyike, Belen Pascual, Aaron Ritter, Erik D. Roberson, Julio C. Rojas, Maria Carmela Tartaglia, Zbigniew K. Wszolek, Howard Rosen, Bradley F. Boeve, Adam L. Boxer, Leonard Petrucelli, Brian S. Appleby, Sami Barmada, Yvette Bordelon, Hugo Botha, Danielle Brushaber, David Clark, Giovanni Coppola, Ryan Darby, Katrina Devick, Dennis Dickson, Kelley Faber, Anne Fagan, Julie A. Fields, Ralitza Gavrilova, Daniel Geschwind, Jill Goldman, Jonathon Graff-Radford, Ian Grant, David T. Jones, Kejal Kantarci, Diana Kerwin, David S. Knopman, John Kornak, Walter Kremers, Maria Lapid, Argentina Lario Lago, Peter Ljubenkov, Diane Lucente, Ian R. Mackenzie, Scott McGinnis, Carly Mester, Bruce L. Miller, Peter Pressman, Rosa Rademakers, Vijay K. Ramanan, E. Marisa Ramos, Katherine P. Rankin, Meghana Rao, Katya Rascovsky, Rodolfo Savica, William Seeley, Adam M. Staffaroni, Jeremy Syrjanen, Jack Taylor, Lawren VandeVrede, Sandra Weintraub, Bonnie Wong
Journal: Cell Reports Medicine (2022)

Frontotemporal dementia (FTD) therapy development is hamstrung by a lack of susceptibility, diagnostic, and prognostic biomarkers. Blood neurofilament light (NfL) shows promise as a biomarker, but studies have largely focused only on core FTD syndromes, often grouping patients with different diagnoses. To expedite the clinical translation of NfL, we avail ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) study resources and conduct a comprehensive investigation of plasma NfL across FTD syndromes and in presymptomatic FTD mutation carriers. We find plasma NfL is elevated in all studied syndromes, including mild cases; increases in presymptomatic mutation carriers prior to phenoconversion; and associates with indicators of disease severity. By facilitating the identification of individuals at risk of phenoconversion, and the early diagnosis of FTD, plasma NfL can aid in participant selection for prevention or early treatment trials. Moreover, its prognostic utility would improve patient care, clinical trial efficiency, and treatment outcome estimations.
Reticulon-1A mediates diabetic kidney disease progression through endoplasmic reticulum-mitochondrial contacts in tubular epithelial cells
Authors: Yifan Xie, Jing E, Hong Cai, Fang Zhong, Wenzhen Xiao, Ronald E. Gordon, Lois Wang, Ya-Li Zheng, Aihua Zhang, Kyung Lee, John Cijiang He
Journal: Kidney International (2022)
Physiology Is Vital to Precision Medicine in Acute Respiratory Distress Syndrome and Sepsis
Authors: Ewan C. Goligher, Irene Telias, Sarina K. Sahetya, Elias Baedorf-Kassis, Bhakti K. Patel, Nadir Yehya, Jonathan A Silversides, Niall D. Ferguson, Laurent J. Brochard, Patrick R. Lawler, Ryan Zarychanski, Arthur S. Slutsky
Journal: American Journal of Respiratory and Critical Care Medicine (2022)
De novo and relapsed immune thrombocytopenia after COVID-19 vaccines: results of French safety monitoring
Authors: Guillaume Moulis, Etienne Crickx, Laure Thomas, Nathalie Massy, Matthieu Mahévas, Marie-Blanche Valnet-Rabier, Marina Atzenhoffer, Marc Michel, Bertrand Godeau, Haleh Bagheri, Francesco Salvo
Journal: Blood (2022)
Dual-Phase 18F-FP-CIT PET in 2 Different Clinical Phenotypes of Sporadic Creutzfeldt-Jakob Disease
Authors: Keun Lee, Dong Gueu Park, Min Seung Kim, Young Sil An, Jung Han Yoon
Journal: Clinical Nuclear Medicine (2022)

Abstract Early diagnosis of Creutzfeldt-Jakob disease (CJD) patients is often challenging due to the low sensitivity of the current clinical diagnostic criteria. We describe MRI and dual-phase 18 F-FP-CIT PET findings in 2 cases of sporadic CJD presenting different clinical phenotypes (Heidenhain variant and corticobasal syndrome). Our case series suggest that dual-phase FP-CIT-PET findings may improve the diagnosis of CJD by combining the perfusion patterns in early phase with the dopamine transporter density in delayed phase. Familiarity with these dual-phase FP-CIT PET findings is helpful for early correct diagnosis of CJD.
Rates of Mutations and Transcript Errors in the Foodborne Pathogen<i>Salmonella enterica</i>subsp.<i>enterica</i>
Authors: Jiao Pan, Weiyi Li, Jiahao Ni, Kun Wu, Iain Konigsberg, Caitlyn E. Rivera, Clayton Tincher, Colin Gregory, Xia Zhou, Thomas G. Doak, Heewook Lee, Yan Wang, Xiang Gao, Michael Lynch, Hongan Long
Journal: Molecular Biology and Evolution (2022)

Abstract Because errors at the DNA level power pathogen evolution, a systematic understanding of the rate and molecular spectra of mutations could guide the avoidance and treatment of infectious diseases. We thus accumulated tens of thousands of spontaneous mutations in 768 repeatedly bottlenecked lineages of 18 strains from various geographical sites, temporal spread, and genetic backgrounds. Entailing over ∼1.36 million generations, the resultant data yield an average mutation rate of ∼0.0005 per genome per generation, with a significant within-species variation. This is one of the lowest bacterial mutation rates reported, giving direct support for a high genome stability in this pathogen resulting from high DNA-mismatch-repair efficiency and replication-machinery fidelity. Pathogenicity genes do not exhibit an accelerated mutation rate, and thus, elevated mutation rates may not be the major determinant for the diversification of toxin and secretion systems. Intriguingly, a low error rate at the transcript level is not observed, suggesting distinct fidelity of the replication and transcription machinery. This study urges more attention on the most basic evolutionary processes of even the best-known human pathogens and deepens the understanding of their genome evolution.
Ocular Gonorrhea
Authors: Yasuhiro Suyama, Reina Akiyama
Journal: New England Journal of Medicine (2022)

A 24-year-old woman presented with pain, yellow discharge, and blurry vision in the left eye. On examination, she could not open the eye. Computed tomography of the orbits showed postseptal extension of inflammation behind the left eye. A culture of the discharge revealed the diagnosis.
Integrated MRI-guided radiotherapy — opportunities and challenges
Authors: Paul J. Keall, Caterina Brighi, Carri Glide-Hurst, Gary Liney, Paul Z. Y. Liu, Suzanne Lydiard, Chiara Paganelli, Trang Pham, Shanshan Shan, Alison C. Tree, Uulke A. van der Heide, David E. J. Waddington, Brendan Whelan
Journal: Nature Reviews Clinical Oncology (2022)
Impact of previous exposure to SARS-CoV-2 and of S-Trimer (SCB-2019) COVID-19 vaccination on the risk of reinfection: a randomised, double-blinded, placebo-controlled, phase 2 and 3 trial
Authors: Igor Smolenov, Htay Htay Han, Ping Li, Carmen Baccarini, Carole Verhoeven, Frank Rockhold, Sue Ann Costa Clemens, Donna Ambrosino, Peter Richmond, George Siber, Joshua Liang, Ralf Clemens
Journal: The Lancet Infectious Diseases (2022)
The impact of SARS-CoV-2 on respiratory syndromic and sentinel surveillance in Israel, 2020: a new perspective on established systems
Authors: Aharona Glatman-Freedman, Lea Gur-Arie, Hanna Sefty, Zalman Kaufman, Michal Bromberg, Rita Dichtiar, Alina Rosenberg, Rakefet Pando, Ital Nemet, Limor Kliker2,, Ella Mendelson, Lital Keinan-Boker, Neta S Zuckerman, Michal Mandelboim
Journal: Eurosurveillance (2022)

BackgroundThe COVID-19 pandemic presented new challenges for the existing respiratory surveillance systems, and adaptations were implemented. Systematic assessment of the syndromic and sentinel surveillance platforms during the pandemic is essential for understanding the value of each platform in the context of an emerging pathogen with rapid global spread.AimWe aimed to evaluate systematically the performance of various respiratory syndromic surveillance platforms and the sentinel surveillance system in Israel from 1 January to 31 December 2020.MethodsWe compared the 2020 syndromic surveillance trends to those of the previous 3 years, using Poisson regression adjusted for overdispersion. To assess the performance of the sentinel clinic system as compared with the national SARS-CoV-2 repository, a cubic spline with 7 knots and 95% confidence intervals were applied to the sentinel network's weekly percentage of positive SARS-CoV-2 cases.ResultsSyndromic surveillance trends changed substantially during 2020, with a statistically significant reduction in the rates of visits to physicians and emergency departments to below previous years' levels. Morbidity patterns of the syndromic surveillance platforms were inconsistent with the progress of the pandemic, while the sentinel surveillance platform was found to reflect the national circulation of SARS-CoV-2 in the population.ConclusionOur findings reveal the robustness of the sentinel clinics platform for the surveillance of the main respiratory viruses during the pandemic and possibly beyond. The robustness of the sentinel clinics platform during 2020 supports its use in locations with insufficient resources for widespread testing of respiratory viruses.
Fighting Cardiac Fibrosis with CAR T Cells
Authors: Scott L. Friedman
Journal: New England Journal of Medicine (2022)

Autologous chimeric antigen receptor T cells, which are engineered to bind and kill cells that express a specific antigen, are effective in the treatment of certain cancers. A recent study involving a mouse model shows that CAR T cells can be generated in vivo and may reduce fibrosis after myocardial injury.
A phenotypic signature that identifies neoantigen-reactive T cells in fresh human lung cancers
Authors: Ken-ichi Hanada, Chihao Zhao, Raul Gil-Hoyos, Jared J. Gartner, Christopher Chow-Parmer, Frank J. Lowery, Sri Krishna, Todd D. Prickett, Scott Kivitz, Maria R. Parkhurst, Nathan Wong, Zachary Rae, Michael C. Kelly, Stephanie L. Goff, Paul F. Robbins, Steven A. Rosenberg, James C. Yang
Journal: Cancer Cell (2022)
PICC vs. midline catheter use for short-term indications was linked to major complications at ≤30 d
Authors: Moises Auron
Journal: Annals of Internal Medicine (2022)

Source Citation Swaminathan L, Flanders S, Horowitz J, et al. Safety and outcomes of midline catheters vs peripherally inserted central catheters for patients with short-term indications: a multicenter study. JAMA Intern Med. 2022;182:50-8. 34842905