tbuckley/cabot-search huggingface dataset:
Prescription change: methyldopa for levodopa
Authors: H. B. Weinberg
Journal: JAMA (1972)

<h3>To the Editor.—</h3> In regard to the first point, the intended reference is to our previous work. We concede that reference to their work was a technical error. In regard to the second point, we concede reference to the paper of Albert and Winters was used inappropriately; the intended reference is to Rodriguez-Soriano.<sup>1</sup>Recent studies in our laboratory<sup>2</sup>employing independent means to measure the rate of endogenous acid production in infants has not led us to alter the figure employed in our article. In regard to the third point, the observation that the titratable acidity of Fre-Amine is higher in our laboratory as compared to that of Dr. Heird et al is most likely due to the differences in the concentration used. The values Dr. Heird quoted are from our laboratory. The excessive gain of acid is amply shown in our studies; take for example, case 1, with
Leads from the MMWR. Recommendations of the Immunization Practices Advisory Committee. Monovalent influenza A(H1N1) vaccine, 1986-1987
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Goulstonian Lectures on the Natural History of Pulmonary Consumption
Authors: A. B. Shepherd
Journal: BMJ (1876)

THE BRITISh MEDICAL 7OURNAL.501 connection with any other renal condition, or with any other morbid state with which we are acquainted.This is evinced by the hardness of the pulse, as evident to the touch, the absence of diastolic col- lapse giving to the vessel a cord-like persistence ; by the force with which the sphygmograph must be brought to bear upon it before a graphic tracing can be obtained; by the abnormal pressure required to obstruct the vessel, as measured by the sphygmnometer of Dr. Hand- -field Jones; and by the alteration in the sounds of the heart, espe- cially by the accentuation and frequent reduplication of the second .sound:evidences, as they have been interpreted, the first of the ab- normal force of the diastolic recoil, owing to the repletion of the .aorticsystem; the second, of the slowness with which, from the same *cause, the left ventricle empties itself, so that the sound which suc-.ceeds upon the completion of the left systole is produced not syn- *chronously with that which follows upon the right, but appreciably later.It is not my purpose, however, to dwell upon this portion of the subject, since it has been brought before the College recently, and with an ability and completeness to which I could not hope to attain.
Antiviral Therapy for Chronic Hepatitis B
Journal: Annals of Internal Medicine (2007)

Treatment of chronic hepatitis B remains a clinical challenge.Long-term viral suppression is a major goal of antiviral therapy to improve the clinical outcome of the patients.Antiviral treatment of chronic hepatitis B relies currently on immune modulators such as interferon alpha and its pegylated form, and viral polymerase inhibitors.Because of the slow kinetics of viral clearance and the spontaneous viral genome variability, viral mutants resistant to nucleoside analogs may be selected.However, the development of new antiviral agents is rapidly improving the offing of therapy of chronic hepatitis B. These new therapeutic advances are reviewed in this manuscript.
Accurate and objective infarct sizing by contrast enhanced magnetic resonance imaging defined in a canine myocardial infarction model
Authors: Luciano Amado, Bernhard Gerber, Dara L. Kraitchman, Khurram Nasir, Ernesto Castillo, Boaz Rosen, Joao A.C. Lima
Journal: Journal of the American College of Cardiology (2003)
Marriages
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P025: Urinary Level of Trimethylamine-N-Oxide Predicts an Increased Risk of Coronary Heart Disease Among Urban Chinese Adults
Authors: Danxia Yu, Xiao-Ou Shu, Emilio Rivera, Xianglan Zhang, Qiuyin Cai, Marion Calcutt, Yong-Bing Xiang, Honglan Li, Yu-Tang Gao, Thomas Wang, Wei Zheng
Journal: Circulation (2019)

Introduction: Trimethylamine-N-oxide (TMAO), a diet-derived, gut microbial-host co-metabolite, has been associated with adverse cardiovascular outcomes in patient populations. However, the evidence is lacking from prospective studies conducted in general populations and in non-Western populations. Hypothesis: TMAO level is associated with risk of coronary heart disease (CHD) in general populations. Methods: We examined associations of urinary TMAO and its precursors (i.e., choline, betaine, and carnitine) with risk of CHD in a case-control study nested within two prospective cohorts of Chinese adults, including 275 incident CHD cases and 275 individually matched controls. Results: Urinary TMAO, but not its precursors, was associated with risk of CHD. Odds ratio (OR, 95% CI) for the highest vs. lowest quartiles of TMAO was 1.91 (1.08-3.35; p-trend=0.008) after adjusting for CHD risk factors including obesity, diet, lifestyles, and metabolic diseases and 1.75 (0.96-3.18; p-trend=0.03) after further adjusting for potential confounders/mediators including central obesity, dyslipidemia, low-grade inflammation, and intakes of seafood and deep-fried meat/fish, which were associated with TMAO level in our study. OR was 1.30 (1.03-1.63) per standard deviation increase in log-TMAO in the fully-adjusted model. History of diabetes modified the TMAO-CHD association. A high TMAO level (≥ vs. &lt;median) showed ORs of 6.21 (1.64-23.6) and 1.56 (1.00-2.43) among diabetic and non-diabetic participants, respectively (p-interaction=0.02). History of diabetes also modified the associations of choline, betaine, and carnitine with risk of CHD with significant positive associations being found among diabetics but null associations among total and non-diabetic participants. Conclusions: Our study suggests that TMAO may play a role in the development of CHD, highlighting the importance of diet-gut microbiota-host interplay in cardiometabolic health.
A psychiatrist in space?
Journal: BMJ (1971)

They should be reassured that if a severe adverse reaction occurs it will quickly disappear if the drug is stopped.At first, close supervision is necessary, and patients often require encouragement to persevere with treatment during the several months that may elapse before real benefit accrues.After the maximum tolerated dose has been reached it may be redistributed in the 24 hours to obtain optimal benefit throughout the day, and minor adjustments may be required from time to time.Even patients who shcw a sustained improvement on levodopa may notice a fluctuation in their functional ability from day to day.8 Once a patient has become familiar with his treatment he need be seen only infrequently, and it is reasonable to prescribe at least one month's supply of drugs at each attendance.
Critique and Cavil... Coffin—II
Authors: George X. Trimble
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Familiar Forms of Nervous Disease.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Synopsis of Physiology.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Invited Commentary on the article “Feasibility and safety of bisegmentectomy 7–8 while preserving hepatic venous outflow of the right liver - A retrospective cohort study” (available online 6 June 2020, https://doi.org/10.1016/j.ijsu.2020.05.075)
Authors: Faramarz Karimian
Journal: International Journal of Surgery (2020)
Prevalence Rates of Amyloid Positivity—Updates and Relevance
Authors: Christina B. Young, Elizabeth C. Mormino
Journal: JAMA Neurology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2022 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
From the Editor's Desk
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ascites and resistance to immune checkpoint inhibition in dMMR/MSI-H metastatic colorectal and gastric cancers
Authors: Giovanni Fucà, Romain Cohen, Sara Lonardi, Kohei Shitara, Maria Elena Elez, Marwan Fakih, Joseph Chao, Samuel J Klempner, Matthew Emmett, Priya Jayachandran, Francesca Bergamo, Marc Díez García, Giacomo Mazzoli, Leonardo Provenzano, Raphael Colle, Magali Svrcek, Margherita Ambrosini, Giovanni Randon, Aakash Tushar Shah, Massimiliano Salati, Elisabetta Fenocchio, Lisa Salvatore, Keigo Chida, Akihito Kawazoe, Veronica Conca, Giuseppe Curigliano, Francesca Corti, Chiara Cremolini, Michael Overman, Thierry Andre, Filippo Pietrantonio
Journal: Journal for ImmunoTherapy of Cancer (2022)

Despite unprecedented benefit from immune checkpoint inhibitors (ICIs) in patients with mismatch repair deficient (dMMR)/microsatellite instability high (MSI-H) advanced gastrointestinal cancers, a relevant proportion of patients shows primary resistance or short-term disease control. Since malignant effusions represent an immune-suppressed niche, we investigated whether peritoneal involvement with or without ascites is a poor prognostic factor in patients with dMMR/MSI-H metastatic colorectal cancer (mCRC) and gastric cancer (mGC) receiving ICIs.
The progressive relationship between increasing Breslow thickness and decreasing survival is lost in patients with ultrathick melanomas (≥15 mm in thickness)
Authors: Mary-Ann El Sharouni, Robert V. Rawson, Vigfús Sigurdsson, Arjen J. Witkamp, Carla H. van Gils, Richard A. Scolyer, John F. Thompson, Paul J. van Diest, Serigne N. Lo
Journal: Journal of the American Academy of Dermatology (2022)
The First Clinical Study of Ara h 6 Relevance in a Pediatric Peanut Allergy Population in the United States
Authors: Jessica Palmieri, Carla Davis, Sara Anvari, Ivan Chinn, Natalia Fernandez Davila, Meera Gupta, Joud Hajjar, Larraine Lyter-Reed, Lenora Noroski, Ashley Reiland, Lisa Forbes Satter, FILIZ SEEBORG, Bob Getts, Paul Kearney, Heather Butler
Journal: Journal of Allergy and Clinical Immunology (2022)
Does Parental Food Allergy History Matter? —Assessing Awareness of NIAID-Sponsored Peanut Allergy Prevention Guidelines and Infant Feeding Practices in a Representative Sample of US Parents
Authors: Sai Nimmagadda, Christopher Warren, Waheeda Samady, Carina Venter, Lucy Bilaver, Joanne Lee, Isabel Galic, Haley Hultquist, Justin Zaslavsky, Ruchi Gupta
Journal: Journal of Allergy and Clinical Immunology (2022)
The Carbon Footprint of Bioinformatics
Authors: Jason Grealey, Loïc Lannelongue, Woei-Yuh Saw, Jonathan Marten, Guillaume Méric, Sergio Ruiz-Carmona, Michael Inouye
Journal: Molecular Biology and Evolution (2022)

Bioinformatic research relies on large-scale computational infrastructures which have a nonzero carbon footprint but so far, no study has quantified the environmental costs of bioinformatic tools and commonly run analyses. In this work, we estimate the carbon footprint of bioinformatics (in kilograms of CO2 equivalent units, kgCO2e) using the freely available Green Algorithms calculator (www.green-algorithms.org, last accessed 2022). We assessed 1) bioinformatic approaches in genome-wide association studies (GWAS), RNA sequencing, genome assembly, metagenomics, phylogenetics, and molecular simulations, as well as 2) computation strategies, such as parallelization, CPU (central processing unit) versus GPU (graphics processing unit), cloud versus local computing infrastructure, and geography. In particular, we found that biobank-scale GWAS emitted substantial kgCO2e and simple software upgrades could make it greener, for example, upgrading from BOLT-LMM v1 to v2.3 reduced carbon footprint by 73%. Moreover, switching from the average data center to a more efficient one can reduce carbon footprint by approximately 34%. Memory over-allocation can also be a substantial contributor to an algorithm's greenhouse gas emissions. The use of faster processors or greater parallelization reduces running time but can lead to greater carbon footprint. Finally, we provide guidance on how researchers can reduce power consumption and minimize kgCO2e. Overall, this work elucidates the carbon footprint of common analyses in bioinformatics and provides solutions which empower a move toward greener research.
2D Covalent Organic Framework Direct Osteogenic Differentiation of Stem Cells
Authors: Sukanya Bhunia, Manish K. Jaiswal, Kanwar Abhay Singh, Kaivalya A. Deo, Akhilesh K. Gaharwar
Journal: Advanced Healthcare Materials (2022)

2D covalent organic frameworks (COFs) are an emerging class of crystalline porous organic polymers with a wide-range of potential applications. However, poor processability, aqueous instability, and low water dispersibility greatly limit their practical biomedical implementation. Herein, a new class of hydrolytically stable 2D COFs for sustained delivery of drugs to direct stem cell fate is reported. Specifically, a boronate-based COF (COF-5) is stabilized using amphiphilic polymer Pluronic F127 (PLU) to produce COF-PLU nanoparticles with thickness of ≈25 nm and diameter ≈200 nm. These nanoparticles are internalized via clathrin-mediated endocytosis and have high cytocompatibility (half-inhibitory concentration ≈1 mg mL-1 ). Interestingly, the 2D COFs induce osteogenic differentiation in human mesenchymal stem cells, which is unique. In addition, an osteogenic agent-dexamethasone-is able to be loaded within the porous structure of COFs for sustained delivery which further enhances the osteoinductive ability. These results demonstrate for the first time the fabrication of hydrolytically stable 2D COFs for sustained delivery of dexamethasone and demonstrate its osteoinductive characteristics.
Associations between Early Life Environmental Exposures and Rhinitis Trajectories in an Urban Birth Cohort
Authors: Sima Ramratnam, Molly Johnson, Agustin Calatroni, Leonard Bacharier, Carin Lamm, Frederic Little, Megan Sandel, Katherine Rivera-Spoljaric, Robert Wood, Ajinkya Limkar, Cynthia Visness, Alkis Togias, Peter Gergen, James Gern
Journal: Journal of Allergy and Clinical Immunology (2022)
Smoking and blood basophils
Authors: S Walter, A Walter
Journal: Thorax (1986)

Chemotherapy in non-small cell bronchial carcinoma SIR,-In the first paragraph of your editorial on the chemotherapy of non-small cell bronchial carcinoma (September 1985;40:641-5) it is stated that very few patients with squamous or large cell carcinoma or adenocarcinoma of the lung are cured by surgery.This is indeed true in relation to the total number of cases of lung cancer each year, but on the other hand it should be emphasised that in the relatively small group of patients who are suitable for surgical treat- ment the five year survival rate (operative mortality ex- cluded) is as high as 25% (to be precise 25.5-26.8% in the review by Belcher of 8781 patients with bronchial carcinoma operated on by seven surgeons in England during the years
Sophistication
Authors: George Ehni
Journal: JAMA (1964)

<h3>To the Editor:—</h3> Medicine, with its history of laureation of pioneers and innovators, is at this moment remiss in not seeking out for notice the man (or woman?) who, not many years back, gave to the word<i>sophistication</i>the new meaning with which it is clothed today. A decade ago, this word meant artificiality, flossiness, adulteration, and other departures from strictness, accuracy, and genuineness and was a term of disapproval except when employed with a tone of mild approval of certain superficialities and artifices of womankind. The charm of this word and its new meaning must be powerful, for one can scarcely read an article now-days without finding concepts, techniques, instrumentations, programmings, and endeavors of all sorts described as possessing<i>sophistication</i>, often of a high degree, signifying, one hopes, something advanced in concept, intricate or complicated in design, or superior to a degree unimaginable only a short time ago. While