tbuckley/cabot-search huggingface dataset:
Emerging roles of microRNA‐208a in cardiology and reverse cardio‐oncology
Authors: Xiang Wang, Xinxin Chen, Hui Xu, Shanshan Zhou, Yang Zheng, Bradley B. Keller, Lu Cai
Journal: Medicinal Research Reviews (2021)

Abstract Cardiovascular diseases (CVDs) and cancer, which are the leading causes of mortality globally, have been viewed as two distinct diseases. However, the fact that cancer and CVDs may coincide has been noted by cardiologists when taking care of patients with CVDs caused by cancer chemotherapy; this entity is designated cardio‐oncology. More recently, patients with CVDs have also been found to have increased risk of cancers, termed reverse cardio‐oncology. Although reverse cardio‐oncology has been highlighted as an important disease state in recent studies, how the diseased heart affects cancer and the potential mediators of the crosstalk between CVDs and cancer are largely unknown. Here, we focus on the roles of cardiac‐specific microRNA‐208a ( miR‐208a ) in cardiac and cancer biology and explore its essential roles in reverse cardio‐oncology. Accumulating evidence has shown that within the heart, increased miR‐208a promotes myocardial injury, arrhythmia, cardiac remodeling, and dysfunction and that secreted miR‐208a in the circulation may have novel roles in promoting tumor proliferation and invasion. This review, therefore, provides insights into the novel roles of miR‐208a in reverse cardio‐oncology and strategies to prevent secondary carcinogenesis in patients with early‐ or late‐stage heart failure.
rePROBE: Workflow for Revised Probe Assignment and Updated Probe-set Annotation in Microarrays
Authors: Frieder Hadlich, Henry Reyer, Michael Oster, Nares Trakooljul, Eduard Muráni, Siriluck Ponsuksili, Klaus Wimmers
Journal: Genomics Proteomics & Bioinformatics (2021)

Abstract Commercial and customized microarrays are valuable tools for the analysis of holistic expression patterns, but require the integration of the latest genomic information. This study provides a comprehensive workflow implemented in an R package (rePROBE) to assign the entire probes and to annotate the probe sets based on up-to-date genomic and transcriptomic information. The rePROBE package can be applied to available gene expression microarray platforms and addresses both public and custom databases. The revised probe assignment and updated probe-set annotation are applied to commercial microarrays available for different livestock species, i.e., chicken (Gallus gallus; ChiGene-1_0-st: 443,579 probes and 18,530 probe sets), pig (Sus scrofa; PorGene-1_1-st: 592,005 probes and 25,779 probe sets), and cattle (Bos Taurus; BovGene-1_0-st: 530,717 probes and 24,759 probe sets), as well as available for human (Homo sapiens; HuGene-1_0-st) and mouse (Mus musculus; HT_MG-430_PM). Using current species-specific transcriptomic information (RefSeq, Ensembl, and partially non-redundant nucleotide sequences) and genomic information, the applied workflow reveals 297,574 probes (15,689 probe sets) for chicken, 384,715 probes (21,673 probe sets) for pig, 363,077 probes (21,238 probe sets) for cattle, 481,168 probes (23,495 probe sets) for human, and 324,942 probes (32,494 probe sets) for mouse. These are representative of 12,641, 15,758, 18,046, 20,167, and 16,335 unique genes that are both annotated and positioned for chicken, pig, cattle, human, and mouse, respectively. Additionally, the workflow collects information on the number of single nucleotide polymorphisms (SNPs) within respective targeted genomic regions and thus provides a detailed basis for comprehensive analyses such as expression quantitative trait locus (eQTL) studies to identify quantitative and functional traits. The rePROBE R package is freely available at https://github.com/friederhadlich/rePROBE.
Seroprevalence of anti-SARS-CoV-2 antibodies after the second pandemic peak
Authors: Silvia Stringhini, María-Eugenia Zaballa, Javier Perez-Saez, Nick Pullen, Carlos de Mestral, Attilio Picazio, Francesco Pennacchio, Ania Wisniak, Aude Richard, Helene Baysson, Andrea Loizeau, Jean-François Balavoine, Didier Trono, Didier Pittet, Klara Posfay-Barbe, Antoine Flahault, François Chappuis, Omar Kherad, Nicolas Vuilleumier, Laurent Kaiser, Andrew S Azman, Idris Guessous
Journal: The Lancet Infectious Diseases (2021)
McKinsey agrees to pay $574m to US states to settle opioid claims
Authors: Owen Dyer
Journal: BMJ (2021)

The consultancy firm McKinsey and Co will pay $574m (£420m; €480m) to resolve claims that it was a driving force behind many of the aggressive sales tactics used by US opioid manufacturers such as Purdue Pharma, the maker of OxyContin.1

The money will go to 47 states, five US territories, and the District of Columbia. Separate settlements will see McKinsey pay another $23m to Washington state and West Virginia. Only Nevada, where an investigation into opioid marketing continues, was not included in the package.

Purdue Pharma itself has agreed to pay $8.3bn in damages but has filed for bankruptcy, and states expect a long wait before they see any money. McKinsey, …
A prospective <scp>STudy</scp> using <scp>invAsive</scp> haemodynamic measurements <scp>foLLowing</scp> catheter ablation for <scp>AF</scp> and early <scp>HFpEF</scp>: <scp>STALL AF‐HFpEF</scp>
Authors: Hariharan Sugumar, Shane Nanayakkara, Donna Vizi, Leah Wright, David Chieng, Angeline Leet, Justin A. Mariani, Aleksandr Voskoboinik, Sandeep Prabhu, Andrew J. Taylor, Jonathan M. Kalman, Peter M. Kistler, David M. Kaye, Liang‐Han Ling
Journal: European Journal of Heart Failure (2021)
Extracorporeal membrane oxygenation in patients with severe respiratory failure from COVID-19
Authors: Shahzad Shaefi, Samantha K. Brenner, Shruti Gupta, Brian P. O’Gara, Megan L. Krajewski, David M. Charytan, Sobaata Chaudhry, Sara H. Mirza, Vasil Peev, Mark Anderson, Anip Bansal, Salim S. Hayek, Anand Srivastava, Kusum S. Mathews, Tanya S. Johns, Amanda Leonberg-Yoo, Adam Green, Justin Arunthamakun, Keith M. Wille, Tanveer Shaukat, Harkarandeep Singh, Andrew J. Admon, Matthew W. Semler, Miguel A. Hernán, Ariel L. Mueller, Wei Wang, David E. Leaf
Journal: Intensive Care Medicine (2021)
Hepatitis B virus integrations promote local and distant oncogenic driver alterations in hepatocellular carcinoma
Authors: Camille Péneau, Sandrine Imbeaud, Tiziana La Bella, Theo Z Hirsch, Stefano Caruso, Julien Calderaro, Valerie Paradis, Jean-Frederic Blanc, Eric Letouzé, Jean-Charles Nault, Giuliana Amaddeo, Jessica Zucman-Rossi
Journal: Gut (2021)

Objective Infection by HBV is the main risk factor for hepatocellular carcinoma (HCC) worldwide. HBV directly drives carcinogenesis through integrations in the human genome. This study aimed to precisely characterise HBV integrations, in relation with viral and host genomics and clinical features. Design A novel pipeline was set up to perform viral capture on tumours and non-tumour liver tissues from a French cohort of 177 patients mainly of European and African origins. Clonality of each integration event was determined with the localisation, orientation and content of the integrated sequence. In three selected tumours, complex integrations were reconstructed using long-read sequencing or Bionano whole genome mapping. Results Replicating HBV DNA was more frequently detected in non-tumour tissues and associated with a higher number of non-clonal integrations. In HCC, clonal selection of HBV integrations was related to two different mechanisms involved in carcinogenesis. First, integration of viral enhancer nearby a cancer-driver gene may lead to a strong overexpression of oncogenes. Second, we identified frequent chromosome rearrangements at HBV integration sites leading to cancer-driver genes ( TERT, TP53, MYC ) alterations at distance. Moreover, HBV integrations have direct clinical implications as HCC with a high number of insertions develop in young patients and have a poor prognosis. Conclusion Deep characterisation of HBV integrations in liver tissues highlights new HBV-associated driver mechanisms involved in hepatocarcinogenesis. HBV integrations have multiple direct oncogenic consequences that remain an important challenge for the follow-up of HBV-infected patients.
A Common Space Approach to Comparative Neuroscience
Authors: Rogier B. Mars, Saad Jbabdi, Matthew F.S. Rushworth
Journal: Annual Review of Neuroscience (2021)

Comparative neuroscience is entering the era of big data. New high-throughput methods and data-sharing initiatives have resulted in the availability of large, digital data sets containing many types of data from ever more species. Here, we present a framework for exploiting the new possibilities offered. The multimodality of the data allows vertical translations, which are comparisons of different aspects of brain organization within a single species and across scales. Horizontal translations compare particular aspects of brain organization across species, often by building abstract feature spaces. Combining vertical and horizontal translations allows for more sophisticated comparisons, including relating principles of brain organization across species by contrasting horizontal translations, and for making formal predictions of unobtainable data based on observed results in a model species.
Community-Based Screening for Prostate Cancer
Authors: Susanna I. Lee, Aileen O’Shea
Journal: JAMA Oncology (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
What We Have Learned from Two Decades of Epidemics and Pandemics: A Systematic Review and Meta-Analysis of the Psychological Burden of Frontline Healthcare Workers
Authors: Isolde M. Busch, Francesca Moretti, Mariangela Mazzi, Albert W. Wu, Michela Rimondini
Journal: Psychotherapy and Psychosomatics (2021)

In light of the current coronavirus disease 2019 (COVID-19) pandemic and potential future infectious disease outbreaks, a comprehensive understanding of the negative effects of epidemics and pandemics on healthcare workers’ mental health could inform appropriate support interventions. Thus, we aimed to synthesize and quantify the psychological and psychosomatic symptoms among frontline medical staff. We searched four databases up to March 19, 2020 and additional literature, with daily search alerts set up until October 26, 2020. Studies reporting psychological and/or psychosomatic symptoms of healthcare workers caring for patients with severe acute respiratory syndrome, H1N1, Ebola, Middle East respiratory syndrome, or COVID-19 were eligible for inclusion. Two reviewers independently conducted the search, study selection, quality appraisal, data extraction, and synthesis and involved a third reviewer in case of disagreement. We used random effects modeling to estimate the overall prevalence rates of psychological/psychosomatic symptoms and the I2 statistic. We included 86 studies, reporting data from 75,991 participants. Frontline staff showed a wide range of symptoms, including concern about transmitting the virus to the family (60.39%, 95% CI 42.53–76.96), perceived stress (56.77%, 95% CI 34.21–77.95), concerns about own health (45.97%, 95% CI 31.08–61.23), sleeping difficulties (39.88%, 95% CI 27.70–52.72), burnout (31.81%, 95% CI 13.32–53.89), symptoms of depression (25.72%, 95% CI 18.34–33.86), symptoms of anxiety (25.36%, 95% CI 17.90–33.64), symptoms of posttraumatic stress disorder (24.51%, 95% CI 18.16–31.46), mental health issues (23.11%, 95% CI 15.98–31.10), and symptoms of somatization (14.68%, 95% CI 10.67–19.18). We found consistent evidence for the pervasive and profound impact of large-scale outbreaks on the mental health of frontline healthcare workers. As the CO­VID-19 crisis continues to unfold, guaranteeing easy access to support structures for the entire healthcare workforce is vitally important.
An Institutional Survey of Patient Satisfaction with Telemedicine Services in Pediatric Allergy During the COVID-19 Pandemic
Authors: Kasey Lanier, Merin Kuruvilla, Jennifer Shih
Journal: Journal of Allergy and Clinical Immunology (2021)

This study investigates parent satisfaction with telemedicine services offered at a pediatric allergy clinic during the SARS-CoV2 pandemic. Our study measured parent satisfaction using a cloud-based platform at an academic institution-based pediatric allergy clinic during the SARS-CoV2 pandemic. All consenting parents of pediatric patients seen in the first two months of the pilot telemedicine program were surveyed using a questionnaire-based satisfaction survey. 135 parents of 191 encounters (70.6%) completed the questionnaire. The most common primary diagnoses were food allergy (31%), asthma (24%), rhinitis (24%), immune deficiency (12%), dermatitis (7%) and urticaria/angioedema (3%). 89% of parents rated their comfort seeing a doctor via telemedicine as 10, and 93% felt their doctor explained their condition in an easily understandable manner. 67% strongly agreed that connecting their appointments was easy. 56% were likely to choose telemedicine over in-person care while 73% would strongly recommend telemedicine services to others. However, only 36% percent strongly agreed that seeing a doctor using telemedicine was just as good as in-person visits, and this was especially endorsed by parents of parents with government insurance (odds ratio 2.9). Interestingly, parents of established patients were significantly less likely to feel comfortable seeing the doctor using telemedicine. Also, parents of patients with government insurance were 2.45 more likely to elect telemedicine. This study underscored parent perceptions and perceived deficiencies in telemedicine services offered by pediatric allergists possibly influenced by demographic factors. Future studies should investigate mechanisms to enhance the telemedicine experience in pediatric allergy so it more closely resembles in-person experiences.
The potential effectiveness of the WHO International Health Regulations capacity requirements on control of the COVID-19 pandemic: a cross-sectional study of 114 countries
Authors: Martin CS Wong, Junjie Huang, Sunny H Wong, Jeremy Yuen-Chun Teoh
Journal: Journal of the Royal Society of Medicine (2021)

Objectives We examined if the WHO International Health Regulations (IHR) capacities were associated with better COVID-19 pandemic control. Design Observational study. Setting Population-based study of 114 countries. Participants General population. Main outcome measures For each country, we extracted: (1) the maximum rate of COVID-19 incidence increase per 100,000 population over any 5-day moving average period since the first 100 confirmed cases; (2) the maximum 14-day cumulative incidence rate since the first case; (3) the incidence and mortality within 30 days since the first case and first COVID-19-related death, respectively. We retrieved the 13 country-specific International Health Regulations capacities and constructed linear regression models to examine whether these capacities were associated with COVID-19 incidence and mortality, controlling for the Human Development Index, Gross Domestic Product, the population density, the Global Health Security index, prior exposure to SARS/MERS and Stringency Index. Results Countries with higher International Health Regulations score were significantly more likely to have lower incidence (β coefficient −24, 95% CI −35 to −13) and mortality (β coefficient −1.7, 95% CI −2.5 to −1.0) per 100,000 population within 30 days since the first COVID-19 diagnosis. A similar association was found for the other incidence outcomes. Analysis using different regression models controlling for various confounders showed a similarly significant association. Conclusions The International Health Regulations score was significantly associated with reduction in rate of incidence and mortality of COVID-19. These findings inform design of pandemic control strategies, and validated the International Health Regulations capacities as important metrics for countries that warrant evaluation and improvement of their health security capabilities.
Abstract 16753: Efficacy & Efficiency of Genome Editing With CRISPR/Cas9 in a Humanized Knock-In Mouse Model of PLNR14del
Authors: Francesca Stillitano, Nour Raad, Lu Zhang, Anthony Fargnoli, Dongtak Jeong, Delaine Ceholski, Erik Kohlbrenner, Jaydev Dave, Chenleng Cai, Fadi Akar, Roger J Hajjar
Journal: Circulation (2018)

Introduction: A mutation in the Phospholamban (PLN) gene, a calcium regulating protein, the Arg14 deletion (R14del), has been identified in patients with atypical Arrhythmogenic Cardiomyopathy (ACM...
Physiological and Pharmacological Roles of PTH and PTHrP in Bone Using Their Shared Receptor, PTH1R
Authors: T John Martin, Natalie A Sims, Ego Seeman
Journal: Endocrine Reviews (2021)

Parathyroid hormone (PTH) and the paracrine factor, PTH-related protein (PTHrP), have preserved in evolution sufficient identities in their amino-terminal domains to share equivalent actions upon a common G protein-coupled receptor, PTH1R, that predominantly uses the cyclic adenosine monophosphate-protein kinase A signaling pathway. Such a relationship between a hormone and local factor poses questions about how their common receptor mediates pharmacological and physiological actions of the two. Mouse genetic studies show that PTHrP is essential for endochondral bone lengthening in the fetus and is essential for bone remodeling. In contrast, the main postnatal function of PTH is hormonal control of calcium homeostasis, with no evidence that PTHrP contributes. Pharmacologically, amino-terminal PTH and PTHrP peptides (teriparatide and abaloparatide) promote bone formation when administered by intermittent (daily) injection. This anabolic effect is remodeling-based with a lesser contribution from modeling. The apparent lesser potency of PTHrP than PTH peptides as skeletal anabolic agents could be explained by lesser bioavailability to PTH1R. By contrast, prolongation of PTH1R stimulation by excessive dosing or infusion, converts the response to a predominantly resorptive one by stimulating osteoclast formation. Physiologically, locally generated PTHrP is better equipped than the circulating hormone to regulate bone remodeling, which occurs asynchronously at widely distributed sites throughout the skeleton where it is needed to replace old or damaged bone. While it remains possible that PTH, circulating within a narrow concentration range, could contribute in some way to remodeling and modeling, its main physiological role is in regulating calcium homeostasis.
New Physical, Mental, and Cognitive Problems 1 Year after ICU Admission: A Prospective Multicenter Study
Authors: Wytske W. Geense, Marieke Zegers, Marco A. A. Peters, Esther Ewalds, Koen S. Simons, Hester Vermeulen, Johannes G. van der Hoeven, Mark van den Boogaard
Journal: American Journal of Respiratory and Critical Care Medicine (2021)

Rationale: Comprehensive studies addressing the incidence of physical, mental, and cognitive problems after ICU admission are lacking. With an increasing number of ICU survivors, an improved understanding of post-ICU problems is necessary. Objectives: To determine the occurrence and cooccurrence of new physical, mental, and cognitive problems among ICU survivors 1 year after ICU admission, their impact on daily functioning, and risk factors associated with 1-year outcomes. Methods: Prospective multicenter cohort study, including ICU patients ⩾16 years of age, admitted for ⩾12 hours between July 2016 and June 2019. Patients, or proxies, rated their health status before and 1 year after ICU admission using questionnaires. Measurements and Main Results: Validated questionnaires were used to measure frailty, fatigue, new physical symptoms, anxiety and depression, post-traumatic stress disorder, cognitive impairment, and quality of life. Of the 4,793 patients included, 2,345 completed the questionnaires both before and 1 year after ICU admission. New physical, mental, and/or cognitive problems 1 year after ICU admission were experienced by 58% of the medical patients, 64% of the urgent surgical patients, and 43% of the elective surgical patients. Urgent surgical patients experienced a significant deterioration in their physical and mental functioning, whereas elective surgical patients experienced a significant improvement. Medical patients experienced an increase in symptoms of depression. A significant decline in cognitive functioning was experienced by all types of patients. Pre-ICU health status was strongly associated with post-ICU health problems. Conclusions: Overall, 50% of ICU survivors suffer from new physical, mental, and/or cognitive problems. An improved insight into the specific health problems of ICU survivors would enable more personalized post-ICU care.
Local Pressure Drives Low-Density Lipoprotein Accumulation and Coronary Atherosclerosis in Hypertensive Minipigs
Authors: Rozh H. Al-Mashhadi, Ahmed L. Al-Mashhadi, Zahra P. Nasr, Martin Bødtker Mortensen, Esmeralda A. Lewis, Emilio Camafeita, Kristian Ravlo, Zheer Al-Mashhadi, Daniel W. Kjær, Johan Palmfeldt, Peter Bie, Jesper M. Jensen, Bjarne L. Nørgaard, Erling Falk, Jesús Vázquez, Jacob F. Bentzon
Journal: Journal of the American College of Cardiology (2021)
Dedicated Device Permits Less Invasive Pancreatic Surgery
Authors: Rebecca Voelker
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Emergence of a Novel SARS-CoV-2 Variant in Southern California
Authors: Wenjuan Zhang, Brian D. Davis, Stephanie S. Chen, Jorge M. Sincuir Martinez, Jasmine T. Plummer, Eric Vail
Journal: JAMA (2021)

This research describes findings of sequencing and phylogenetic analyses of SARS-CoV-2 isolates from symptomatic patients cared for at Cedar-Sinai Medical Center in November-December 2020 during a regional surge in cases and hospitalizations.