AB0633 HEALTH RELATED QUALITY OF LIFE IN GOUT, PSORIATIC ARTHRITIS, RHEUMATOID ARTHRITIS AND ANKYLOSING SPONDYLITIS: RESULTS FROM A QUESTIONNAIRE STUDY
Authors: A. Landgren, M. Dehlin, L. T. H. Jacobsson, U. Bergsten, E. Klingberg
Journal: Annals of the Rheumatic Diseases (2021)

Background: Gout, psoriatic arthritis (PsA), rheumatoid arthritis (RA), ankylosing spondylitis (AS), are common inflammatory joint diseases (IJD) that substantially affect HRQoL (Health Related Quality of Life). To our knowledge, this is the first study comparing HRQoL in gout, PsA, RA and AS in the same setting. Objectives: To compare HRQoL assessed with the Short Form health survey (SF-36) between gout, PsA, RA and AS. Methods: We performed a cross-sectional questionnaire study in Sweden. Individuals ≥18 years and with at least one ICD-10 diagnosis for gout, PsA, RA, or AS, recorded at a health care visit to a physician at a rheumatology clinic (for all diagnoses) or at a primary care center (for gout patients) from 2015 through 2017 were identified. Patients with gout (n=1589), PsA (n=1200), RA (n=1246) and AS (n=1095) were sent a questionnaire including questions regarding Visual Analogue Scales (VAS) for General Health, Pain, Fatigue, Health Asssessment Questionnaire (HAQ), as well as the SF-36. The eight domains (a higher score indicating a better health status) as well as the overall physical (PCS) and mental (MCS) component scores (a value of 50 corresponds to unaffected HRQoL) of the SF-36 are presented. Respondents were matched on age, sex. ANOVA was used for between group comparisons of mean values. For non-normally distributed data, Kruskal Wallis test was used. For comparing distributions, the Chi-Square test was used. Results: In total, 2896 (56.5%) individuals responded. After matching for age, sex, 249 individuals per diagnosis group remained. Gout patients reported significantly higher scores on SF-36 subscales as well as PCS (consistent with results seen before matching for age and sex). Lower values of HRQoL were noted in physical domains as compared to mental domains in all IJDs. Disability measured by HAQ was significantly lower in gout and VAS scores were more favourable compared to other IJDs. Conclusion: Patients with gout report higher HRQOL compared to PsA, RA, AS. Table 1. Age-matched comparisons across diagnoses Gout PsA RA AS p-value p-value Gout vs PsA p-value Gout vs RA p-value Gout vs AS p-value PsA vs RA p-value PsA vs AS p-value RA v AS Total (n) 249 249 249 249 N/A Age, mean (SD) 62.5 (11.2) 64.2 (10.2) 63.1 (11.6) 62.8 (10.5) NS Education ≤12 years, n (%) 132 (53.0) 148 (59.4) 160 (64.3) 139 (55.8) NS HAQ, mean (SD) 0.19 (0.40) 0.48 (0.55) 0.60 (0.63) 0.58 (0.58) *** *** *** *** NS NS NS VAS General Health, mean (SD) 2.6 (2.3) 3.7 (2.4) 3.8 (2.6) 4.0 (2.3) *** *** *** *** NS NS NS VAS Pain, mean (SD) 2.6 (2.4) 4.0 (2.6) 3.8 (2.6) 4.2 (2.4) *** *** *** *** NS NS NS VAS Fatigue, mean (SD) 3.6 (2.6) 4.5 (2.7) 4.3 (2.6) 4.9 (2.5) *** *** * *** NS NS * SF-36 domains, median (IQR ) Physical function 90.0 (75.0-95.0) 70.0 (51.3-95.0) 70.0 (45.0-90.0) 75.0 (50.0-90.0) *** *** *** *** NS NS NS Role physical 100.0 (33.3-100.0) 50.0 (0.0-100.0) 50.0 (0.0-100.0) 50.0 (0.0-100.0) *** *** *** *** NS NS NS Bodily pain 72.0 (42.0-100.0) 52.0 (41.0-74.0) 52.0 (41.0-74.0) 52.0 (41.0-64.0) *** *** *** *** NS NS NS General Health 67.0 (47.8-80.8) 56.0 (35.0-72.0) 55.0 (37.0-72.0) 50.0 (35.0-71.0) *** *** *** *** NS NS NS Vitality 65.0 (50.0-77.5) 57.5 (37.5-75.0) 57.5 (42.5-72.5) 50.0 (32.5-70.0) *** * * *** NS NS NS Social function 100.0 (68.8-100.0) 81.3 (57.8-100.0) 81.3 (67.2-100.0) 81.3 (50.0-100.0) *** ** ** *** NS NS NS Role emotional 100.0 (66.7-100.0) 100.0 (33.3-100.0) 100.0 (33.3-100.0) 100.0 (33.3-100.0) ** NS ** ** NS NS NS Mental health 82.0 (66.0-92.0) 78.0 (60.0-92.0) 78.0 (60.0-92.0) 73.0 (60.0-88.0) ** NS * ** NS NS NS SF-36 summary scores, median (IQR ) Physical component score 48.4 (38.8-54.7) 40.2 (28.5-50.2) 40.2 (28.2-49.0) 38.7 (30.1-48.2) *** *** *** *** NS NS NS Mental component score 51.7 (43.7-56.5) 51.0 (39.2-56.4) 50.7 (39.6-56.3) 47.7 (37.1-55.3) * NS NS * NS NS NS HAQ=Health Assessment questionnaire IRQ=Interquartile range SD=Standard deviation VAS=Visual Analogue Scale NS=non-significant *=significant at p&lt;0.05 **=significant at p&lt;0.01 ***=significant at p&lt;0.001 Disclosure of Interests: None declared.