tbuckley/cabot-search huggingface dataset:
Abstract P1-24-02: Genetic variants and tumor microenvironment in inflammatory breast cancer: Clues for targeted therapies
Authors: Maria F. Arisi, Yulan Gong, Rajeswari Nagarathinam, Lorenzo Gerratana, Jianming Pei, Kathy Q. Cai, Jennifer Winn, Zachary Hasse, Elias Obeid, Julio Noriega, Christopher Sebastiano, Eric Ross, R. Katherine Alpaugh, Massimo Cristofanilli, Sandra V Fernandez
Journal: Cancer Research (2022)

Abstract Background: Inflammatory breast cancer (IBC) is characterized by a young age at diagnosis, high metastatic potential, and poor overall survival. To better understand the etiology of this aggressive disease, we performed a retrospective study to evaluate genomic alterations and tumor microenvironment in IBC patients. Methods: Targeted next generation sequencing (NGS) was performed using blood cell-free DNA (cfDNA) (n=32), paired DNA from tumor tissues (n=29) and DNA from whole blood or normal tissue (n=20). We also characterized the tumor infiltrating lymphocytes (TILs) in tumor tissue biopsies by studying several markers (CD4, CD8, FoxP3, CD20, PD-1 and PD-L1) through immunohistochemistry (IHC) staining. Results: Our results shown a high incidence of germline variants in patients with IBC that could be associated with an increased risk of developing the disease. Germline variants were found more frequently in patients with TN (38.9%) than non-TN IBC (28.6%). IHC staining revealed that in 7 of 24 (29%) patients, tumor biopsies were positive for PD-L1 and PD-1 expression on TILs. Patients with PD-L1&amp;PD-1 positive biopsies had a lower OS (31 months) than patients with PD-L1&amp;PD-1 negative (38 months) tumors, though the difference was not statistically significant. PD-L1&amp;PD-1 positive tumors had significantly more CD8+ (cytotoxic T-cells), CD20+ (B-cells) and FoxP3+ (Tregs) cells than PD-L1&amp;PD-1 negative ones. Furthermore, most IBC patients showed to have deficiencies in the homologous recombination repair (HRR) pathway (BRCA1, BRCA2, PALB2, RAD51C, ATM, BARD1) making them sensitive to poly (ADP-ribose) polymerase (PARP) inhibitors. All tumor biopsies showed positive staining for p-FAK1(Tyr 397). Conclusion: A subset of IBC patients (29%) expressed both PD-L1 and PD-1 on tumor immune cells infiltrates, providing rationale for testing PD-1/PD-L1 blocking therapies. IBC patients could have benefits from PD-1/PD-L1 blocking therapies alone or in combination with PARP or FAK (Tyr397) kinase inhibitors, both having the capacity of altering the tumor microenvironment. Citation Format: Maria F. Arisi, Yulan Gong, Rajeswari Nagarathinam, Lorenzo Gerratana, Jianming Pei, Kathy Q. Cai, Jennifer Winn, Zachary Hasse, Elias Obeid, Julio Noriega, Christopher Sebastiano, Eric Ross, R. Katherine Alpaugh, Massimo Cristofanilli, Sandra V Fernandez. Genetic variants and tumor microenvironment in inflammatory breast cancer: Clues for targeted therapies [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P1-24-02.
Resmetirom (MGL-3196) in Patients With Heterozygous Familial Hypercholesterolemia
Authors: G. Kees Hovingh, Ib Christian Klausen, Eli Heggen, Kevin McCarty, Rong Zhou, Barton F. Isaac, Rebecca Taub, Gisle Langslet, John J.P. Kastelein
Journal: Journal of the American College of Cardiology (2022)
Family interventions for relapse prevention in schizophrenia: a systematic review and network meta-analysis
Authors: Alessandro Rodolico, Irene Bighelli, Chiara Avanzato, Carmen Concerto, Pierfelice Cutrufelli, Ludovico Mineo, Johannes Schneider-Thoma, Spyridon Siafis, Maria Salvina Signorelli, Hui Wu, Dongfang Wang, Toshi A Furukawa, Gabi Pitschel-Walz, Eugenio Aguglia, Stefan Leucht
Journal: The Lancet Psychiatry (2022)
Errors in Figures 1 and 2
Journal: JAMA Psychiatry (2022)

Markku Lähteenvuo, MD, PhD; Antti Tanskanen, PhLic; Heidi Taipale, PhD; Fabian Hoti, PhD; Pia Vattulainen, MSc; Eduard Vieta, MD, PhD; Jari Tiihonen, MD, PhD
CLO22-080: Correlation of Imaging and Biochemical Modalities in Identifying the Exact Anatomical Site of Origin of Tumour in Periampullary Carcinoma – A Prospective Observational Study
Authors: Satyaki Roy, Rajesh Gupta, Vikas Gupta, Harjeet Singh, Mandeep Kang, Surinder Rana, Ritambhara Nada, Yashwant Kumar
Journal: Journal of the National Comprehensive Cancer Network (2022)

"CLO22-080: Correlation of Imaging and Biochemical Modalities in Identifying the Exact Anatomical Site of Origin of Tumour in Periampullary Carcinoma – A Prospective Observational Study" published on 31 Mar 2022 by National Comprehensive Cancer Network.
INVESTIGATION INTO THE MANAGEMENT AND OUTCOMES OF TYPE B ACUTE AORTIC DISSECTION PATIENTS PRESENTING IN SHOCK
Authors: Cody C. Horton, Eduardo Bossone, Thoralf M. Sundt, Ibrahim Sultan, Harleen Sandhu, Santi Trimarchi, Roland Van Kimmenade, Qing-Guo Li, Bradley Taylor, Chih-Wen Pai, Andrew Shaffer, Melissa Levack, Dan Gilon, Derek Brinster, Alan C. Braverman, Christoph A. Nienaber, Kim A. Eagle
Journal: Journal of the American College of Cardiology (2022)
9P Preliminary population pharmacokinetic (popPK) co-variates and exposure response (ER) assessment of QT for RP-3500, a highly potent and specific inhibitor of ataxia telangiectasia and Rad3-related (ATR) protein kinase
Authors: E. Lee, T.A. Yap, E. Fontana, E. Rosen, D. Spigel, S. Lheureux, N.B. Mettu, L. Carter, R. Plummer, S. Patel, R. McDougall, R. Papp, S. May, P. Nejad, D. Ulanet, M. Wainszelbaum, P. Manley, M. Koehler, A.J. Fretland, M. Højgaard
Journal: Annals of Oncology (2022)
RELATIONSHIP BETWEEN CORONARY ARTERY CALCIUM AND STRESS-INDUCED PERFUSION ABNORMALITY IN PATIENTS UNDERGOING RB-82 PET MPI
Authors: Donghee Han, Pankaj Malhotra, Robert JH Miller, Yuka Otaki, Heidi Gransar, Sean W. Hayes, Louise Thomson, John D. Friedman, Alan Rozanski, Piotr Slomka, Daniel S. Berman
Journal: Journal of the American College of Cardiology (2022)
REAL-WORLD EFFICACY AND SAFETY OF DUAL ANTIPLATELET THERAPY WITH TICAGRELOR AS COMPARED TO CLOPIDOGREL IN ACUTE CORONARY SYNDROME PATIENTS TREATED WITH PERCUTANEOUS CORONARY INTERVENTION
Authors: Evan Wiens, Silvia J. Leon, Reid Whitlock, Navdeep Tangri, Ashish Shah
Journal: Journal of the American College of Cardiology (2022)
SARS-COV-2 INFECTION AFTER CTEPH DIAGNOSIS ASSOCIATED WITH VASCULAR TISSUE FRIABILITY DURING PULMONARY THROMBOENDARTERECTOMY
Authors: Anil Kumar Jonnalagadda, Paul Forfia, Suad Taraif, William Auger, Estefania Oliveros Soles, William Moser, Susan Thomas, Yoshiya Toyoda, Anjali Vaidya
Journal: Journal of the American College of Cardiology (2022)
Annals Graphic Medicine - Burn, COVID, Burn
Authors: Arun Thekkekarott Kuruvila, Nikita Hegde
Journal: Annals of Internal Medicine (2022)

Web ExclusivesMarch 2022Annals Graphic Medicine - Burn, COVID, BurnFREEArun Thekkekarott Kuruvila, MBBS, MD and Nikita Hegde, MBBS, MDArun Thekkekarott Kuruvila, MBBS, MDAsante Rogue Regional Medical Center, Medford, Oregon (A.T.K.)Search for more papers by this author and Nikita Hegde, MBBS, MDA.J. Institute of Medical Sciences, Mangalore, India (N.H.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/G21-0086 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Download figure Download PowerPoint Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: Asante Rogue Regional Medical Center, Medford, Oregon (A.T.K.)A.J. Institute of Medical Sciences, Mangalore, India (N.H.)Disclosures: Authors have reported no disclosures of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=G21-0086.Author/Illustrator Information: Arun Thekkekarott Kuruvila, MBBS, MD, is a hospitalist in Oregon and an acclaimed artist who has displayed his artwork at high-quality exhibitions in India and the United States (e-mail, [email protected]com). Nikita Hegde, MBBS, MD, is an anesthesiologist and art enthusiast (e-mail, [email protected]com).This article was published at Annals.org on 22 February 2022. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics March 2022Volume 175, Issue 3Page: W41-W42 ePublished: 22 February 2022 Issue Published: March 2022 Copyright & PermissionsCopyright © 2022 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Clinical Characteristics and Outcomes of Nonalcoholic Fatty Liver Disease–Associated Hepatocellular Carcinoma in the United States
Authors: Mohammad A. Karim, Amit G. Singal, Hye Chung Kum, Yi-Te Lee, Sulki Park, Nicole E. Rich, Mazen Noureddin, Ju Dong Yang
Journal: Clinical Gastroenterology and Hepatology (2022)
EFFECT OF COOLING METHODS AND TARGET TEMPERATURE SELECTION ON OUTCOMES IN COMATOSE PATIENTS RESUSCITATED FROM CARDIAC ARREST: SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS
Authors: Toshiki Kuno, Shingo Matsumoto, Takahisa Mikami, Hisato Takagi, Alexandros Briasoulis, Daniel Sims, Jason Neil Katz, Jacob Colin Jentzer, Sripal Bangalore, Carlos Alviar
Journal: Journal of the American College of Cardiology (2022)
ANALYSIS OF BOTH SEX AND DEVICE SPECIFIC FACTORS ON OUTCOMES IN PATIENTS WITH NONISCHEMIC CARDIOMYOPATHY (BIO-LIBRA): FIRST INTERIM RESULTS
Authors: Valentina Kutyifa, Luigi Di Biase, Karthik Prasad, Vilma Torres, Aaron B. Hesselson, Craig J. McCotter, Gregory Harris, Karlene Cox, Susan Schleede, Ilan Goldenberg, Scott McNitt, Mary W. Brown, Crystal Miller, Christopher Beck, Jeanne E. Poole
Journal: Journal of the American College of Cardiology (2022)
DIAGNOSTIC ACCURACY OF COMPUTED TOMOGRAPHY-BASED FRACTIONAL FLOW RESERVE WITH A NOVEL COARSE-TO-FINE SUBPIXEL ALGORITHM IN DETECTING HEMODYNAMICALLY SIGNIFICANT STENOSIS: A PROSPECTIVE MULTICENTER STUDY
Authors: Xiao Wang, Yaping Zeng, Zhe Tang, Tianchang Li, Xuejun Jiang, Fusui Ji, Yujie Zhou, Junbo Ge, Zhanquan Li, Yanyan Zhao, Changsheng Ma, Gary S. Mintz, Shaoping Nie
Journal: Journal of the American College of Cardiology (2022)
THE ASSOCIATION OF QUANTITATIVE AND SEMI-QUANTITATIVE PROTEINURIA WITH ADVERSE OUTCOMES IN ATRIAL FIBRILLATION
Authors: Alicia Serrano, Lu Han, Peter Austin, Paul Dorian, Cynthia Jackevicius, Douglas Lee, Ayodele Odutayo, Sheldon M.S. Singh, Karen Tu, Dennis T. Ko, Husam Mohamed Abdel-Qadir
Journal: Journal of the American College of Cardiology (2022)
Propagation of tau and α-synuclein in the brain: therapeutic potential of the glymphatic system
Authors: Douglas M. Lopes, Sophie K. Llewellyn, Ian F. Harrison
Journal: Translational Neurodegeneration (2022)

Many neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, are characterised by the accumulation of misfolded protein deposits in the brain, leading to a progressive destabilisation of the neuronal network and neuronal death. Among the proteins that can abnormally accumulate are tau and α-synuclein, which can propagate in a prion-like manner and which upon aggregation, represent the most common intracellular proteinaceous lesions associated with neurodegeneration. For years it was thought that these intracellular proteins and their accumulation had no immediate relationship with extracellular homeostasis pathways such as the glymphatic clearance system; however, mounting evidence has now suggested that this is not the case. The involvement of the glymphatic system in neurodegenerative disease is yet to be fully defined; however, it is becoming increasingly clear that this pathway contributes to parenchymal solute clearance. Importantly, recent data show that proteins prone to intracellular accumulation are subject to glymphatic clearance, suggesting that this system plays a key role in many neurological disorders. In this review, we provide a background on the biology of tau and α-synuclein and discuss the latest findings on the cell-to-cell propagation mechanisms of these proteins. Importantly, we discuss recent data demonstrating that manipulation of the glymphatic system may have the potential to alleviate and reduce pathogenic accumulation of propagation-prone intracellular cytotoxic proteins. Furthermore, we will allude to the latest potential therapeutic opportunities targeting the glymphatic system that might have an impact as disease modifiers in neurodegenerative diseases.
TRIGLYCERIDE GLUCOSE INDEX PREDICTS RISK OF CARDIO-METABOLIC AND MORTALITY OUTCOMES AMONG CHINESE ADULTS — A TERRITORY-WIDE LONGITUDINAL STUDY
Authors: Jeremy Hui, Jiandong Zhou, Oscar Chou, Sharen Lee, Jeffrey Chan, Yan Hiu A. Lee, Wing Tak Wong, Keith Leung, Abraham Wai, Tong Liu, Bernard Cheung, Gary Tse, Qingpeng Zhang
Journal: Journal of the American College of Cardiology (2022)
PREVALENCE AND OUTCOMES OF PATIENTS WITHOUT STANDARD MODIFIABLE RISK FACTORS FOLLOWING ACUTE CORONARY SYNDROME: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Bryan Chong, Rachel Goh, Gwyneth Kong, Cheng Han Ng, Roger Sik-Yin Foo, Adrian Low, Chi-Hang Lee, Mark Y.Y. Chan, Huay-Cheem Tan, Poay Huan Loh, Nicholas Chew
Journal: Journal of the American College of Cardiology (2022)
Recent progress in the imaging of c‐Met aberrant cancers with positron emission tomography
Authors: Giuseppe Floresta, Vincenzo Abbate
Journal: Medicinal Research Reviews (2022)

Abstract Tyrosine‐protein kinase Met—also known as c‐Met or HGFR—is a membrane receptor protein with associated tyrosine kinase activity physiologically stimulated by its natural ligand, the hepatocyte growth factor (HGF), and is involved in different ways in cancer progression and tumourigenesis. Targeting c‐Met with pharmaceuticals has been preclinically proved to have significant benefits for cancer treatment. Recently, evaluating the protein status during and before c‐Met targeted therapy has been shown of relevant importance by different studies, demonstrating that there is a correlation between the status (e.g., aberrant activation and overexpression) of the HGFR with therapy response and clinical prognosis. Currently, clinical imaging based on positron emission tomography (PET) appears as one of the most promising tools for the in vivo real‐time scanning of irregular alterations of the tyrosine‐protein kinase Met and for the diagnosis of c‐Met related cancers. In this study, we review the recent progress in the imaging of c‐Met aberrant cancers with PET. Particular attention is directed on the development of PET probes with a range of different sizes (HGF, antibodies, anticalines, peptides, and small molecules), and radiolabeled with different radionuclides. The goal of this review is to report all the preclinical imaging studies based on PET imaging reported until now for in vivo diagnosis of c‐Met in oncology to support the design of novel and more effective PET probes for in vivo evaluation of c‐Met.
MYOCARDIAL DEFORMATION BY SPECKLE TRACKING AS A PREDICTOR OF EARLY POSTOPERATIVE COMPLICATIONS IN PATIENTS WITH MULTI-VESSEL CORONARY ARTERY DISEASE AND NORMAL LEFT VENTRICULAR EJECTION FRACTION UNDERGOING CORONARY ARTERY BYPASS GRAFT SURGERY
Authors: Mariana M. Cano-Nieto, Jorge Moragues, Katy Ellenberger, Jennifer Yu, Greg Cranney, Gita Mathur, Jose E. Gutierrez-Aguilar, Jose A. Arias-Godinez, Edith L. Posada-Martinez
Journal: Journal of the American College of Cardiology (2022)
Sex Differences in Cardiac Rehabilitation Outcomes
Authors: Joshua R. Smith, Randal J. Thomas, Amanda R. Bonikowske, Shane M. Hammer, Thomas P. Olson
Journal: Circulation Research (2022)

Cardiovascular disease is a leading cause of morbidity and mortality in males and females in the United States and globally. Cardiac rehabilitation (CR) is recommended by the American Heart Association/American College of Cardiology for secondary prevention for patients with cardiovascular disease. CR participation is associated with improved cardiovascular disease risk factor management, quality of life, and exercise capacity as well as reductions in hospital admissions and mortality. Despite these advantageous clinical outcomes, significant sex disparities exist in outpatient phase II CR programming. This article reviews sex differences that are present in the spectrum of care provided by outpatient phase II CR programming (ie, from referral to clinical management). We first review CR participation by detailing the sex disparities in the rates of CR referral, enrollment, and completion. In doing so, we discuss patient, health care provider, and social/environmental level barriers to CR participation with a particular emphasis on those barriers that majorly impact females. We also evaluate sex differences in the core components incorporated into CR programming (eg, patient assessment, exercise training, hypertension management). Next, we review strategies to mitigate these sex differences in CR participation with a focus on automatic CR referral, female-only CR programming, and hybrid CR. Finally, we outline knowledge gaps and areas of future research to minimize and prevent sex differences in CR programming.
Altered propionate metabolism contributes to tumour progression and aggressiveness
Authors: Ana P. Gomes, Didem Ilter, Vivien Low, Stanislav Drapela, Tanya Schild, Edouard Mullarky, Julie Han, Ilaria Elia, Dorien Broekaert, Adam Rosenzweig, Michal Nagiec, Joana B. Nunes, Bethany E. Schaffer, Anders P. Mutvei, John M. Asara, Lewis C. Cantley, Sarah-Maria Fendt, John Blenis
Journal: Nature Metabolism (2022)
CLO22-075: Hereditary Retinoblastoma: Same Disease, Different Aetiologies
Authors: Ana Carolina Tamayo Palacio, Alejandra del Pilar Reyes de la Rosa, Perla Rocio Robledo Ramirez, Nidia Anaid Huerta Bolfeta, Linda Beatriz Muñoz Martinez, Ariadna Berenice Morales Jimenez, Rodrigo Moreno Salgado
Journal: Journal of the National Comprehensive Cancer Network (2022)
Intra-articular Platelet-Rich Plasma vs Placebo Injection and Pain and Medial Tibial Cartilage Volume in Patients With Knee Osteoarthritis
Authors: Yiting Lei, Danli Cui, Wei Huang
Journal: JAMA (2022)

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PREVALENCE AND PROGNOSTIC SIGNIFICANCE OF MALNUTRITION IN PATIENTS WITH CORONARY ARTERY DISEASE TREATED WITH PERCUTANEOUS CORONARY INTERVENTION: A RETROSPECTIVE COHORT STUDY
Authors: Se Hun Kang, Won-Jang Kim, Jong-Pil Park, Da Hye Kim, Seon Min Park, Jieun Song, Jisu Ko
Journal: Journal of the American College of Cardiology (2022)
Abstract P3-20-05: Trends of axillary treatment in sentinel node-positive breast cancer patients undergoing amputation
Authors: Eline EF Verreck, Julia van Steenhoven, Anne Kuijer, Marissa van Maaren, Sabine Siesling, Thijs van Dalen
Journal: Cancer Research (2022)

Abstract Objectives: To evaluate patterns of care in axillary treatment of Dutch patients - who were diagnosed with stage I-IV primary invasive breast cancer, underwent amputation and were found positive by sentinel lymph node biopsy (SLNB) - in the years following the publication of the American College for Surgeons Oncology Group (ACOSOG)-Z0011 and After Mapping of the Axilla: Radiotherapy Or Surgery (AMAROS) trials. Methods: Data from females diagnosed between January 1st 2009 and December 31st 2018 were obtained from the Netherlands Cancer Registry (NKR). Trends in completion axillary lymph node dissection (cALND), administration of adjunctive radiotherapy and, inversely, of omission of any kind of axillary treatment, were revealed by descriptive analyses on SNL positive patients. Results: Of 28,070 cT1-4 breast cancer patients undergoing amputation with SLNB from 2009 up until 2018, 10,706 were diagnosed as SLN positive. In the latter, the frequency of subsequent cALND went down significantly from 78% in 2009 to 10% in 2018 (P &amp;lt; 0.001), while adjunctive radiotherapy increased from 4% to 49% (P &amp;lt; 0.001). Omission of any additional local treatment increased from 18% to 41% (P &amp;lt; 0.001). In N1 patients cALND decreased from 57% to 13% (P &amp;lt; 0.001) and was mostly replaced by radiotherapy, increasing from 2% to 70% (P &amp;lt; 0.001). In N1mi and N0i+ patients, cALND decreased to less than 1% of cases in 2018, while radiotherapy increased from 4% to 40% and 8% to 13% (P &amp;lt; 0.001), respectively. Conclusion: In SLN positive breast cancer patients undergoing breast amputation, cALND had become rare 10 years following the AMAROS and Z0011 trial results. While radiotherapy mostly replaced cALND in the vast majority of N1 patients, less than half of N1mi and only a tenth of N0i+ patients received radiotherapy as the only adjunctive axillary treatment by the end of 2018. Citation Format: Eline EF Verreck, Julia van Steenhoven, Anne Kuijer, Marissa van Maaren, Sabine Siesling, Thijs van Dalen. Trends of axillary treatment in sentinel node-positive breast cancer patients undergoing amputation [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P3-20-05.
Amyloid Arthropathy and Pseudomyopathy Associated With Multiple Myeloma Detected by 18F-Florapronol Amyloid PET/CT
Authors: Minjung Seo, Yoo Jin Lee, Misung Kim, Byeong Seong Kang, Seol Hoon Park
Journal: Clinical Nuclear Medicine (2022)

Abstract We report a case of amyloid arthropathy and pseudomyopathy with multiple myeloma, detected by amyloid PET/CT using 18 F-florapronol. Bone scintigraphy and 18 F-FDG PET/CT in a multiple myeloma patient revealed uneven soft tissue uptakes, especially at periarticular areas. The joint capsule and intermuscular fascia showed enhancement on CT, whereas muscle enzymes were normal. These suggested amyloid arthropathy with pseudomyopathy. 18 F-Florapronol amyloid PET/CT showed extensive soft tissue uptakes. Amyloid arthropathy and pseudomyopathy were confirmed after biopsy. This is the first report of amyloid PET/CT aiding in the diagnosis of unusual presentation of systemic amyloidosis.