tbuckley/cabot-search huggingface dataset:
Cold urticaria – What we know and what we do not know
Authors: Natalya Maltseva, Elena Borzova, Daria Fomina, Mojca Bizjak, Dorothea Terhorst‐Molawi, Mitja Košnik, Kanokvalai Kulthanan, Raisa Meshkova, Simon Francis Thomsen, Marcus Maurer
Journal: Allergy (2020)

Cold urticaria (ColdU) is a common form of chronic inducible urticaria characterized by the development of wheals, angioedema or both in response to cold exposure. Recent research and guideline updates have advanced our understanding and management of ColdU. Today, its pathophysiology is thought to involve the cold-induced formation of autoallergens and IgE to these autoallergens, which provoke a release of proinflammatory mediators from skin mast cells. The classification of ColdU includes typical and atypical subtypes. We know that cold-induced wheals usually develop on rewarming and resolve within an hour and that anaphylaxis can occur. The diagnosis relies on the patient's history and cold stimulation testing. Additional diagnostic work-up, including a search for underlying infections, should only be done if indicated by the patient's history. The management of ColdU includes cold avoidance, the regular use of nonsedating antihistamines and the off-label use of omalizumab. However, many questions regarding ColdU remain unanswered. Here, we review what is known about ColdU, and we present important unanswered questions on the epidemiology, underlying pathomechanisms, clinical heterogeneity and treatment outcomes. Our aim is to guide future efforts that will close these knowledge gaps and advance the management of ColdU.
13772 Safety and efficacy of VP-102 in molluscum contagiosum (MC) by lesion count quartile: Pooled results of two phase 3 multicenter, randomized, vehicle-controlled trials for the topical treatment of MC
Authors: Lawrence F. Eichenfield, Pearl Kwong, Mercedes E. Gonzalez, Anthony J. Mancini, Melissa Olivadoti, Patrick Burnett
Journal: Journal of the American Academy of Dermatology (2020)
Identification of a Patients-Derived CD34+ Myeloma Cell Population with Tumor-Propagating Capacity and Resistance to Anticancer Drugs
Authors: Kentaro Serizawa, Hirokazu Tanaka, Ayano Fukui, Ryosuke Fujiwara, Keigo Sano, Hiroaki Inoue, Takahiro Kumode, Yasuhiro Taniguchi, Yasuyoshi Morita, Luis Espinoza, Itaru Matsumura
Journal: Blood (2017)
Cannabis and Impaired Driving
Authors: Thomas B. Cole, Richard Saitz
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Persistent symptoms 1.5–6 months after COVID-19 in non-hospitalised subjects: a population-based cohort study
Authors: Knut Stavem, Waleed Ghanima, Magnus Kringstad Olsen, Hanne Margrethe Gilboe, Gunnar Einvik
Journal: Thorax (2020)

This study assessed symptoms and their determinants 1.5–6 months after symptom onset in non-hospitalised subjects with confirmed COVID-19 until 1 June 2020, in a geographically defined area. We invited 938 subjects; 451 (48%) responded. They reported less symptoms after 1.5–6 months than during COVID-19; median (IQR) 0 (0–2) versus 8 (6–11), respectively (p&lt;0.001); 53% of women and 67% of men were symptom free, while 16% reported dyspnoea, 12% loss/disturbance of smell, and 10% loss/disturbance of taste. In multivariable analysis, having persistent symptoms was associated with the number of comorbidities and number of symptoms during the acute COVID-19 phase.
Noninvasive Assessment of Coronary Artery Bypass Graft Disease: The Potential Role of Contrast-Enhanced Cardiac Magnetic Resonance⁎⁎Editorials published in JACC: Cardiovascular Imaging reflect the views of the authors and do not necessarily represent the views of JACC: Cardiovascular Imaging or the American College of Cardiology.
Authors: Sven Plein
Journal: JACC. Cardiovascular imaging (2009)
Computational modelling suggests that Barrett’s oesophagus may be the precursor of all oesophageal adenocarcinomas
Authors: Kit Curtius, Joel H Rubenstein, Amitabh Chak, John M Inadomi
Journal: Gut (2020)

Objective Barrett’s oesophagus (BE) is a known precursor to oesophageal adenocarcinoma (OAC) but current clinical data have not been consolidated to address whether BE is the origin of all incident OAC, which would reinforce evidence for BE screening efforts. We aimed to answer whether all expected prevalent BE, diagnosed and undiagnosed, could account for all incident OACs in the US cancer registry data. Design We used a multiscale computational model of OAC that includes the evolutionary process from normal oesophagus through BE in individuals from the US population. The model was previously calibrated to fit Surveillance, Epidemiology and End Results cancer incidence curves. Here, we also utilised age-specific and sex-specific US census data for numbers at-risk. The primary outcome for model validation was the expected number of OAC cases for a given calendar year. Secondary outcomes included the comparisons of resulting model-predicted prevalence of BE and BE-to-OAC progression to the observed prevalence and progression rates. Results The model estimated the total number of OAC cases from BE in 2010 was 9970 (95% CI: 9140 to 11 980), which recapitulates nearly all OAC cases from population data. The model simultaneously predicted 8%–9% BE prevalence in high-risk males age 45–55, and 0.1%–0.2% non-dysplastic BE-to-OAC annual progression in males, consistent with clinical studies. Conclusion There are likely few additional OAC cases arising in the US population outside those expected from individuals with BE. Effective screening of high-risk patients could capture the majority of population destined for OAC progression and potentially decrease mortality through early detection and curative removal of small (pre)cancers during surveillance.
Stimuli‐Responsive Iron Oxide Nanotheranostics: A Versatile and Powerful Approach for Cancer Therapy
Authors: Morgan E. Lorkowski, Prabhani U. Atukorale, Ketan B. Ghaghada, Efstathios Karathanasis
Journal: Advanced Healthcare Materials (2020)

Abstract Recent advancements in unravelling elements of cancer biology involved in disease progression and treatment resistance have highlighted the need for a holistic approach to effectively tackle cancer. Stimuli‐responsive nanotheranostics based on iron oxide nanoparticles are an emerging class of versatile nanomedicines with powerful capabilities to “seek, sense, and attack” multiple components of solid tumors. In this work, the rationale for using iron oxide nanoparticles and the basic physical principles that impact their function in biomedical applications are reviewed. Subsequently, recent advances in the integration of iron oxide nanoparticles with various stimulus mechanisms to facilitate the development of stimuli‐responsive nanotheranostics for application in cancer therapy are summarized. The integration of an iron oxide core with various surface coating mechanisms results in the generation of hybrid nanoconstructs with capabilities to codeliver a wide variety of highly potent anticancer therapeutics and immune modulators. Finally, emerging future directions and considerations for their clinical translation are touched upon.
Abstract 15768: Does Vitamin D/Calcium Supplement Intake Worsen Aortic Stenosis Progression?
Authors: Antonette Karrthik, Keerat Rai Ahuja, Mohamed M Gad, Najdat Bazarbashi, Manpreet Kaur, Patrick Collier, Milind Desai, Brian P Griffin, Samir Kapadia
Journal: Circulation (2019)

Introduction: Vitamin D and calcium supplement intake are on the rise among the elderly population. Limited knowledge exists on their influence on valvular stenosis progression. We aimed to identif...
KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy
Authors: Ioannis D. Kyriazis, Matthew Hoffman, Lea Gaignebet, Anna Maria Lucchese, Eftychia Markopoulou, Dimitra Palioura, Chao Wang, Thomas D. Bannister, Melpo Christofidou-Solomidou, Shin-ichi Oka, Junichi Sadoshima, Walter J. Koch, Ira J. Goldberg, Vincent W. Yang, Agnieszka B. Bialkowska, Georgios Kararigas, Konstantinos Drosatos
Journal: Circulation Research (2020)

Diabetic cardiomyopathy (DbCM) is a major complication in type-1 diabetes, accompanied by altered cardiac energetics, impaired mitochondrial function, and oxidative stress. Previous studies indicate that type-1 diabetes is associated with increased cardiac expression of KLF5 (Krüppel-like factor-5) and PPARα (peroxisome proliferator-activated receptor) that regulate cardiac lipid metabolism.
Nutritional Control of Intestinal Stem Cells in Homeostasis and Tumorigenesis
Authors: Gizem Calibasi-Kocal, Omid Mashinchian, Yasemin Basbinar, Ender Ellidokuz, Chia-Wei Cheng, Ömer H. Yilmaz
Journal: Trends in Endocrinology and Metabolism (2020)
18P A prospective randomized study comparing cosmetic outcome of sequential electron boost versus simultaneous integrated boost with IMRT to lumpectomy cavity during adjuvant radiotherapy to breast following BCS in carcinoma breast in Indian patients
Authors: S. Bommera, V.P.B. Koyyala, S.K. Sharma, K.S. Chufal, S.R. Barik, A. Pahuja, S. Dutta, G. Srivasthav, P. Medisetty, A. Jajodia, S. Pasricha
Journal: Annals of Oncology (2020)
Organ Acceptance and Outcomes—A Surgeon’s Perspective
Authors: Kathryn E. Engelhardt, Sameer Hirji, Muhammad F. Masood
Journal: JAMA Cardiology (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
An Integrated Epigenomic and Transcriptomic Map of Mouse and Human αβ T Cell Development
Authors: Laura B. Chopp, Vishaka Gopalan, Thomas Ciucci, Allison Ruchinskas, Zachary Rae, Manon Lagarde, Yayi Gao, Caiyi Li, Marita Bosticardo, Francesca Pala, Ferenc Livak, Michael C. Kelly, Sridhar Hannenhalli, Rémy Bosselut
Journal: Immunity (2020)
Injectable muscle-adhesive antioxidant conductive photothermal bioactive nanomatrix for efficiently promoting full-thickness skeletal muscle regeneration
Authors: Li Zhou, Juan Ge, Min Wang, Mi Chen, Wei Cheng, Wenchen Ji, Bo Lei
Journal: Bioactive Materials (2020)

The completed skeletal muscle regeneration resulted from severe injury and muscle-related disease is still a challenge. Here, we developed an injectable muscle-adhesive antioxidant conductive bioactive photothermo-responsive nanomatrix for regulating the myogenic differentiation and promoting the skeletal muscle regeneration in vivo. The multifunctional nanomatrix was composed of polypyrrole@polydopamine (PPy@PDA, 342 ± 5.6 nm) nanoparticles-crosslinked Pluronic F-127 (F127)-polycitrate matrix (FPCP). The FPCP nanomatrix demonstrated inherent multifunctional properties including excellent photothermo-responsive and shear-thinning behavior, muscle-adhesive feature, injectable ability, electronic conductivity (0.48 ± 0.03 S/m) and antioxidant activity and photothermal function. The FPCP nanomatrix displayed better photothermal performance with near-infrared irradiation, which could provide the photo-controlled release of protein (91% ± 2.6% of BSA was released after irradiated 3 times). Additionally, FPCP nanomatrix could significantly enhance the cell proliferation and myogenic differentiation of mouse myoblast cells (C2C12) by promoting the expressions of myogenic genes (MyoD and MyoG) and myosin heavy chain (MHC) protein with negligible cytotoxicity. Based on the multifunctional properties, FPCP nanomatrix efficiently promoted the full-thickness skeletal muscle repair and regeneration in vivo, through stimulating the angiogenesis and myotube formation. This study firstly indicated the vital role of multifunctional PPy@PDA nanoparticles in regulating myogenic differentiation and skeletal muscle regeneration. This work also suggests that rational design of bioactive matrix with multifunctional feature would greatly enhance the development of regenerative medicine.
Increased Arterial Wave Reflection Magnitude: A Novel Form of Stage B Heart Failure?⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Authors: Sanjiv J. Shah, J. Andrew Wasserstrom
Journal: Journal of the American College of Cardiology (2012)
Tirant Stealthily Invaded Natural<i>Drosophila melanogaster</i>Populations during the Last Century
Authors: Florian Schwarz, Filip Wierzbicki, Kirsten-André Senti, Robert Kofler
Journal: Molecular Biology and Evolution (2020)

It was long thought that solely three different transposable elements (TEs)-the I-element, the P-element, and hobo-invaded natural Drosophila melanogaster populations within the last century. By sequencing the "living fossils" of Drosophila research, that is, D. melanogaster strains sampled from natural populations at different time points, we show that a fourth TE, Tirant, invaded D. melanogaster populations during the past century. Tirant likely spread in D. melanogaster populations around 1938, followed by the I-element, hobo, and, lastly, the P-element. In addition to the recent insertions of the canonical Tirant, D. melanogaster strains harbor degraded Tirant sequences in the heterochromatin which are likely due to an ancient invasion, likely predating the split of D. melanogaster and D. simulans. These degraded insertions produce distinct piRNAs that were unable to prevent the novel Tirant invasion. In contrast to the I-element, P-element, and hobo, we did not find that Tirant induces any hybrid dysgenesis symptoms. This absence of apparent phenotypic effects may explain the late discovery of the Tirant invasion. Recent Tirant insertions were found in all investigated natural populations. Populations from Tasmania carry distinct Tirant sequences, likely due to a founder effect. By investigating the TE composition of natural populations and strains sampled at different time points, insertion site polymorphisms, piRNAs, and phenotypic effects, we provide a comprehensive study of a natural TE invasion.
Abstract 13279: The Association Between Insulin Resistance And Incident Heart Failure In The Aric Study
Authors: Orly Vardeny, Deepak Gupta, Brian Claggett, Stuart L Burke, Amil Shah, Laura R Loehr, Laura Rasmussen-Torvik, Elizabeth Selvin, Patricia P Chang, David Aguilar, Scott D Solomon
Journal: Circulation (2012)

Background: Diabetes mellitus (DM) increases the risk for heart failure (HF), but the association of insulin resistance (IR) and HF in population without DM is unclear. We assessed whether IR was a...
Photoreceptor Diversification Accompanies the Evolution of Anthozoa
Authors: Sebastian G Gornik, Bruno Gideon Bergheim, Benoit Morel, Alexandros Stamatakis, Nicholas S Foulkes, Annika Guse
Journal: Molecular Biology and Evolution (2020)

Abstract Anthozoan corals are an ecologically important group of cnidarians, which power the productivity of reef ecosystems. They are sessile, inhabit shallow, tropical oceans and are highly dependent on sun- and moonlight to regulate sexual reproduction, phototaxis, and photosymbiosis. However, their exposure to high levels of sunlight also imposes an increased risk of UV-induced DNA damage. How have these challenging photic environments influenced photoreceptor evolution and function in these animals? To address this question, we initially screened the cnidarian photoreceptor repertoire for Anthozoa-specific signatures by a broad-scale evolutionary analysis. We compared transcriptomic data of more than 36 cnidarian species and revealed a more diverse photoreceptor repertoire in the anthozoan subphylum than in the subphylum Medusozoa. We classified the three principle opsin classes into distinct subtypes and showed that Anthozoa retained all three classes, which diversified into at least six subtypes. In contrast, in Medusozoa, only one class with a single subtype persists. Similarly, in Anthozoa, we documented three photolyase classes and two cryptochrome (CRY) classes, whereas CRYs are entirely absent in Medusozoa. Interestingly, we also identified one anthozoan CRY class, which exhibited unique tandem duplications of the core functional domains. We next explored the functionality of anthozoan photoreceptors in the model species Exaiptasia diaphana (Aiptasia), which recapitulates key photo-behaviors of corals. We show that the diverse opsin genes are differentially expressed in important life stages common to reef-building corals and Aiptasia and that CRY expression is light regulated. We thereby provide important clues linking coral evolution with photoreceptor diversification.
MT1-MMP-LOX-1軸による内皮細胞の酸化型低濃度リポ蛋白質に誘導されたGiを通じたRhoA及びRac1の活性化調節
Authors: Sugimoto K, Ishibashi T, Kamioka M, Uekita H, Ohkawara H, Sakamoto N, Sawamura T, Takuwa Y, Teramoto T, Manuyama Y
Journal: Circulation (2006)
Abstract 14164: Reduction in ApoB Levels After a Single Dose of MEDI6012 in Subjects Receiving High-Intensity Statin Therapy Suggests Enhancement of Low-Density Lipoprotein Receptor-Mediated Reverse Cholesterol Transport
Authors: Liron Abuhsira, Sotirios Karathanasis, Dewei She, Boaz Hirshberg, Richard T George
Journal: Circulation (2017)

Introduction: MEDI6012 is recombinant human lecithin-cholesterol acyltransferase (rhLCAT). LCAT is the rate-limiting enzyme in reverse cholesterol transport (RCT) that facilitates the esterificatio...
166P Differences and similarities in presentation and management patterns in patients with hepatocellular carcinoma (HCC) across Hong Kong, Singapore and Thailand
Authors: P.K.H. Chow, J-F. Baladi, Y. Chia, B. Ramaswamy, V. Grillo, A. Acorda, K. Xu, S. Singh, Y. Chen, Y. Gilliam, R. Gowindah
Journal: Annals of Oncology (2020)
Partha Kar: Delivering covid vaccine—a team effort
Authors: Partha Kar
Journal: BMJ (2020)

Ripples of hope have emerged in recent weeks, with the possibility of a working covid-19 vaccine. There are still many hurdles—demonstrating safety and efficacy, overcoming production challenges, and convincing the public amid a torrent of fake news and anti-vaxxer rhetoric. But an overarching optimism has arisen, after the tough months the world has lived through this year.

The next phase will be hugely important for the NHS—delivery. Expect heated discussions around who will get a vaccine “first”: if it’s healthcare professionals, why not teachers or shielded groups? As ever, the debate will be played out in public, shot through with politics, bias, and vested interests. We must also consider the practicalities of delivering the vaccine during a …
16443 Prevalence and impact of psychosocial comorbidities on health status among patients with moderate to severe atopic dermatitis in the United States: Analysis of the 2017 US National Health and Wellness Survey
Authors: Shawn G. Kwatra, Amy H. Huang, Mamta Jhaveri, David Gruben, Selwyn Fung, Marco DiBonaventura
Journal: Journal of the American Academy of Dermatology (2020)
375O Final efficacy results from IMpower132: First-line atezolizumab + chemotherapy in patients with stage IV non-squamous NSCLC
Authors: M. Nishio, F. Barlesi, S. Ball, R. Bordoni, M. Cobo, P. Dubray-Longeras, J. Goldschmidt, S. Novello, F.J. Orlandi, R. Sanborn, Z. Szalai, G. Ursol, D. Mendus, L. Wang, X. Wen, M. McCleland, T. Hoang, S. Phan, M. Socinski
Journal: Annals of Oncology (2020)
Sampling interstitial fluid from human skin using a microneedle patch
Authors: Pradnya P. Samant, Megan M. Niedzwiecki, Nicholas Raviele, Vilinh Tran, Juan Mena-Lapaix, Douglas I. Walker, Eric I. Felner, Dean P. Jones, Gary W. Miller, Mark R. Prausnitz
Journal: Science Translational Medicine (2020)

Tissue interstitial fluid (ISF) surrounds cells and is an underutilized source of biomarkers that complements conventional sources such as blood and urine. However, ISF has received limited attention due largely to lack of simple collection methods. Here, we developed a minimally invasive, microneedle-based method to sample ISF from human skin that was well tolerated by participants. Using a microneedle patch to create an array of micropores in skin coupled with mild suction, we sampled ISF from 21 human participants and identified clinically relevant and sometimes distinct biomarkers in ISF when compared to companion plasma samples based on mass spectrometry analysis. Many biomarkers used in research and current clinical practice were common to ISF and plasma. Because ISF does not clot, these biomarkers could be continuously monitored in ISF similar to current continuous glucose monitors but without requiring an indwelling subcutaneous sensor. Biomarkers distinct to ISF included molecules associated with systemic and dermatological physiology, as well as exogenous compounds from environmental exposures. We also determined that pharmacokinetics of caffeine in healthy adults and pharmacodynamics of glucose in children and young adults with diabetes were similar in ISF and plasma. Overall, these studies provide a minimally invasive method to sample dermal ISF using microneedles and demonstrate human ISF as a source of biomarkers that may enable research and translation for future clinical applications.
Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer’s Disease
Authors: Minghui Wang, Aiqun Li, Michiko Sekiya, Noam D. Beckmann, Xiuming Quan, Nadine Schrode, Michael B. Fernando, Alex Yu, Li Zhu, Jiqing Cao, Liwei Lyu, Emrin Horgusluoglu, Qian Wang, Lei Guo, Yuan-shuo Wang, Ryan Neff, Won-min Song, Erming Wang, Qi Shen, Xianxiao Zhou, Chen Ming, Seok-Man Ho, Sezen Vatansever, H. Ümit Kaniskan, Jian Jin, Ming-Ming Zhou, Kanae Ando, Lap Ho, Paul A. Slesinger, Zhenyu Yue, Jun Zhu, Pavel Katsel, Sam Gandy, Michelle E. Ehrlich, Valentina Fossati, Scott Noggle, Dongming Cai, Vahram Haroutunian, Koichi M. Iijima, Eric Schadt, Kristen J. Brennand, Bin Zhang
Journal: Neuron (2020)