tbuckley/cabot-search huggingface dataset:
Efficacy of a single-lead unipolar transvenous defibrillator compared with a system employing an additional coronary sinus electrode. A prospective, randomized study.
Authors: P JKudenchuk, G HBardy, G LDolack, J EPoole, RMehra, GJohnson
Journal: Circulation (1994)

BACKGROUNDRecent development of a prototype single-lead unipolar transvenous defibrillator offers the possibility of device implantation with the ease of a permanent pacemaker. Lowering defibrillation energy requirements would allow for a further reduction in defibrillator generator size and enhance the feasibility of pacemaker-like placement. However, if achieving a lower defibrillation energy requires placing additional intracardiac leads, the potential advantage of a smaller generator may be offset by the disadvantages of a more complex lead system. The purpose of this study was to compare defibrillation energy requirements of a single-lead unipolar defibrillator with a three-electrode system employing an additional lead in the coronary sinus.METHODS AND RESULTSTesting of a single-lead unipolar biphasic pulse defibrillation system versus a three-electrode system with an additional coronary sinus lead was performed in prospective, randomized fashion in 15 patients with a history of ventricular tachycard...
Ambulatory arrhythmias in resuscitated victims of cardiac arrest.
Authors: W DWeaver, L ACobb, A PHallstrom
Journal: Circulation (1982)

One hundred forty-four patients with coronary heart disease previously resuscitated from out-of-hospital ventricular fibrillation underwent 24-hour ambulatory ECG monitoring 5 months (median) after cardiac arrest. Patients were then followed for an average of 31.7 months. Fifty-one patients died, 32 from subsequent unexpected cardiac arrest. One hundred twenty-nine patients (90%) had uniform ventricular ectopy. Two-thirds had complex ventricular ectopy (Bigeminy/trigeminy, repetitive forms or frequent multiforms). Complex ectopy, present in 20% or more of the 30-minute recording intervals, occurred in 18 of the patients (56%) who developed subsequent cardiac arrest, compared with 26 of 92 (28%) who survived (P less than 0.005, specificity 72%, relative risk 2.3). Other forms of ventricular ectopy, e.g., uniform, multiform and repetitive beats, were more sensitive but less specific predictors of death or recurrent ventricular fibrillation. Complex ventricular ectopy was associated with certain clinical his...
Laparoscopic Lavage vs Primary Resection for Perforated Diverticulitis—Reply
Authors: Johannes Kurt Schultz, Sheraz Yaqub, Tom Øresland
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intramuscular administration of human tissue-type plasminogen activator in rabbits and dogs and its implications for coronary thrombolysis.
Authors: B ESobel, J ESaffitz, L EFields, D WMyears, S JSarnoff, A KRobison, D AOwensby, K AFox
Journal: Circulation (1987)

To determine whether sustained plasma concentration of human tissue-type plasminogen activator (t-PA) can be induced promptly after intramuscular injection with enhancers of absorption devoid of deleterious local and systemic effects, we studied 250 rabbits and 13 dogs. In rabbits with t-PA injected directly into exposed muscle followed by local electrical stimulation at the site, early absorption was increased markedly by addition of 0.63M methylamine plus 0.079M hydroxylamine to the excipient. Elevations peaked within 5 min and increased with dose of t-PA, concentration of methylamine, and volume of injection medium. The enhancers were effective with percutaneous injections in the absence of local electrical stimulation as well. They did not elicit any obviously deleterious local or systemic effects. In separate experiments in rats, intramuscular injections of 0.63M methylamine plus 0.079M hydroxylamine induced local egress of intravascular radiolabeled albumin within the injection site and endothelial ...
Pertussis toxin-sensitive G protein mediates coronary microvascular control during autoregulation and ischemia in canine heart.
Authors: TKomaru, YWang, KAkai, KSato, NSekiguchi, ASugimura, TKumagai, HKanatsuka, KShirato
Journal: Circulation Research (1994)

GTP-binding regulatory proteins (G proteins) regulate various biological functions, but their participation in controlling coronary microvascular tone has not been established yet. The goal of the present study was to elucidate the role of pertussis toxin (PTX)-sensitive G protein in regulating coronary microvascular tone during autoregulation and ischemia. In 42 open-chest dogs, coronary arterial microvessels on the surface of the left ventricle were directly observed by epi-illuminated fluorescence microangiography using a floating objective system. PTX (300 ng/mL) was superfused onto the surface of the left ventricle for 2 hours to block Gi and G(o) protein in epimyocardial coronary microvessels in vivo. PTX superfusion caused no change in the resting diameters of microvessels and significantly blocked the vasoconstriction induced by BHT 920 (a selective alpha 2-agonist). After pretreatment with PTX or its vehicle, the left anterior descending coronary artery (LAD) was occluded by a hydraulic occluder ...
Shall The Journal be Removed to Washington?
Authors: B. F. Rolfe
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Gift in Precision Medicine: Unwrapping the Significance of Reciprocity and Generosity
Authors: Randi Zlotnik Shaul, Dylan Shaul, James Anderson, Melissa McCradden
Journal: The American Journal of Bioethics (2021)

This article is referred to by:Response to Open Peer Commentaries: Distinguishing the “Gift” from “Donation” as a Path toward Reciprocity and Relational Ethics
Delayed immune-related adverse events with anti-PD-1-based immunotherapy in melanoma
Authors: C.N. Owen, X. Bai, T. Quah, S.N. Lo, C. Allayous, S. Callaghan, C. Martínez-Vila, R. Wallace, P. Bhave, I.L.M. Reijers, N. Thompson, V. Vanella, C.L. Gerard, S. Aspeslagh, A. Labianca, A. Khattak, M. Mandala, W. Xu, B. Neyns, O. Michielin, C.U. Blank, S.J. Welsh, A. Haydon, S. Sandhu, J. Mangana, J.L. McQuade, P.A. Ascierto, L. Zimmer, D.B. Johnson, A. Arance, P. Lorigan, C. Lebbé, M.S. Carlino, R.J. Sullivan, G.V. Long, A.M. Menzies
Journal: Annals of Oncology (2021)
High molecular weight proteins purified from cardiac junctional sarcoplasmic reticulum vesicles are ryanodine-sensitive calcium channels.
Authors: D PRardon, D CCefali, R DMitchell, S MSeiler, L RJones
Journal: Circulation Research (1989)

The cardiac high molecular weight proteins/ryanodine receptors were purified to homogeneity from junctional sarcoplasmic reticulum membranes and shown to exhibit large conductance calcium channel activity. High molecular weight proteins were solubilized from junctional sarcoplasmic reticulum in zwitterionic detergent and purified by size-exclusion chromatography followed by sucrose density gradient centrifugation. The purified proteins exhibited an apparent Mr = 400,000-350,000, and bound [3H]ryanodine with a Kd of 4.6 nM and a Bmax of 140-280 pmol/mg protein. High molecular weight proteins demonstrated divalent cation channel activity after incorporation into planar lipid bilayers. Two channel types were identified. Large conductance channels had a slope conductance of 96 +/- 13 pS and a Erev of 42 +/- 9 mV (n = 5); small conductance channels had a slope conductance of 5.5 +/- 1 pS [1.0 microM cis CaCl2; 50 mM trans Ba(OH)2]. Reducing cis calcium from 1 microM to 1 nM reduced the large conductance channe...
Nonuniform recovery of excitability in the left ventricle.
Authors: J AVassallo, D MCassidy, K EKindwall, F EMarchlinski, M EJosephson
Journal: Circulation (1988)

The purpose of this study was to determine left ventricular activation, dispersion of refractoriness, and total recovery time in patients with coronary artery disease and ventricular tachycardia and in patients with the long QT syndrome and to compare these patients with a group of normal patients. Left ventricular endocardial catheter mapping and left ventricular refractory period determination were performed in 18 patients. Group 1 consisted of seven patients with no heart disease and no arrhythmia; group 2 consisted of six patients with previous infarction and sustained ventricular tachycardia; and group 3 consisted of five patients with prolonged QT interval and previous cardiac arrest. Total left ventricular endocardial activation was significantly longer in group 2 (75 +/- 23 msec, mean +/- SD) compared with group 1 (34 +/- 9 msec, p less than 0.01) and group 3 (42 +/- 5 msec, p less than 0.05). Dispersion of refractoriness was significantly greater in group 3 (87 +/- 27 msec) than in group 1 (40 +/...
Unexpected 99mTcO4 − Uptake by Lung Adenocarcinoma
Authors: Luisa Knappe, Barbara Muoio, Paola Migliora, Gaetano Paone, Luca Giovanella
Journal: Clinical Nuclear Medicine (2021)

A 76-year-old woman underwent 99mTcO4- thyroid scintigraphy to clarify thyrotoxicosis. In addition to suppressed thyroid uptake, an atypical tracer accumulation appeared on already know pulmonary adenocarcinoma in the left lung upper lobe. Surgical pathology was reviewed confirming the diagnosis of lung adenocarcinoma with focal mucins production and excluding a misdiagnosed differentiated thyroid carcinoma metastasis.
Guidance for Setting Alternative Competence Criteria for Optical Diagnosis of Diminutive Colorectal Polyps: A Simulation Approach
Authors: BBSL Houwen, MJE Greuter, JLA Vleugels, Y Hazewinkel, E Dekker, VMH Coupé
Journal: Endoscopy (2021)

Aims Current competence criteria [PIVI] for optical diagnosis of diminutive colorectal polyps are clinically relevant but difficult to measure and implement in daily practice. These criteria are defined as follows; (PIVI-1) ≥90 % surveillance agreement and (PIVI-2) ≥90 % negative predictive value (NPV) for neoplastic histology in the rectosigmoid with histology as reference. To provide guidance for setting alternative easy-to-implement competence criteria, we determined the proportion of diminutive polyps that should have a correct optical diagnosis to meet the currently used PIVI.
Potential fields on the ventricular surface of the exposed dog heart during normal excitation.
Authors: GArisi, EMacchi, SBaruffi, SSpaggiari, BTaccardi
Journal: Circulation Research (1983)

We studied the normal spread of excitation on the anterior and posterior ventricular surface of open-chest dogs by recording unipolar electrograms from an array of 1124 electrodes spaced 2 mm apart. The array had the shape of the ventricular surface of the heart. The electrograms were processed by a computer and displayed as epicardial equipotential maps at 1-msec intervals. Isochrone maps also were drawn. Several new features of epicardial potential fields were identified: (1) a high number of breakthrough points; (2) the topography, apparent widths, velocities of the wavefronts and the related potential drop; (3) the topography of positive potential peaks in relation to the wavefronts. Fifteen to 24 breakthrough points were located on the anterior, and 10 to 13 on the posterior ventricular surface. Some were in previously described locations and many others in new locations. Specifically, 3 to 5 breakthrough points appeared close to the atrioventricular groove on the anterior right ventricle and 2 to 4 ...
Mitral valve prolapse in patients with prior rheumatic fever.
Authors: N JLembo, L JDell'Italia, M HCrawford, J FMiller, K LRichards, R AO'Rourke
Journal: Circulation (1988)

It is known that rheumatic heart disease frequently results in isolated mitral regurgitation without concomitant mitral stenosis, especially in countries with a high prevalence of rheumatic fever. However, more recent surgical pathologic data also have demonstrated a high incidence of mitral valve prolapse in cases of rheumatic heart disease, which suggests that rheumatic fever may be a cause of mitral valve prolapse. To determine whether this association of mitral valve prolapse and rheumatic heart disease is present in a stable clinic population, we studied 30 patients who had an apical systolic murmur and a well-documented history of rheumatic fever with dynamic auscultation, two-dimensional echocardiography, and pulsed Doppler examinations. Twenty of the 30 patients (67%) had findings on physical examination consistent with isolated mitral regurgitation and 25 patients (84%) had mitral regurgitation by Doppler examination. Echocardiography demonstrated mitral valve prolapse in 24 patients (80%), where...
Catheter-mediated electrical ablation: the relation between current and pulse width on voltage breakdown and shock-wave generation.
Authors: G HBardy, FColtorti, R BStewart, H LGreene, T DIvey
Journal: Circulation Research (1988)

Voltage waveform breakdown is characteristic of barotraumatic shock-wave generation during electrical catheter ablation of cardiac arrhythmias. The purpose of this investigation was to avoid barotrauma by defining, in vitro, the limits of pulse amplitude and pulse width for rectangular constant-current pulses that do not result in voltage breakdown and subsequently to determine what pulsing frequency is safe for use when high-energy trains of pulses are used. Electric pulses were delivered with a variable waveform modulator with a wide dynamic range and bandwidth capable of delivering pulses of 30-10,000-mu sec duration with amplitudes of up to 25 A. Cathodal pulses were delivered to a 6F catheter immersed in fresh anticoagulated bovine blood warmed to 37 degrees C to stimulate the milieu of a catheter in the chambers of the human heart. The maximum pulse amplitude that could be delivered without incurring voltage waveform breakdown varied inversely with pulse duration. Pulses of 30 mu sec broke down at c...
Preventing Firearm Violence
Authors: T. Steven Roosevelt
Journal: Annals of Internal Medicine (1995)

Letters15 November 1995Preventing Firearm ViolenceT. Steven Roosevelt, MD, PhDT. Steven Roosevelt, MD, PhDIdaho Diabetes and Endocrine Associates; Boise, ID 83702Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-10-199511150-00033 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I believe that the College's recent recommendation on gun ownership [1] is fundamentally flawed. The recommendation is contrary to long-standing criminologic experience, violates the fundamental rights enjoyed by a free people, and, if enacted as law, might increase firearm-related deaths.Cesare Beccaria [2], the founder of scientific criminology, understood the folly of gun control laws in practical terms: False is the idea of utility that sacrifices a thousand real advantages for one imaginary or trifling inconvenience.… The laws that forbid the carrying of arms are of such a nature. They disarm those only who are neither inclined ...References1. American College of Physicians. Preventing firearm violence: a public health imperative. Ann Intern Med. 1995; 122:311-3. Google Scholar2. Beccaria C. On Crimes and Punishment. Indianapolis, IN: Bobbs-Merrill; 1963:87-8. Google Scholar3. Reiss AJ, Roth JA, eds. Understanding and Preventing Violence. Washington, DC: National Academy Pr; 1993:266. Google Scholar4. Kleck G. Handgun-only gun control: a policy disaster in the making. In: Kates DB. ed. Firearms and Violence: Issues in Public Policy. Cambridge, MA: Ballinger Pr; 1984:167-99. Google Scholar5. Warner K, ed. Gun Digest: 1995. Northbrook, IL: DBI; 1995:219-24. Google Scholar Author, Article, and Disclosure InformationAuthors: T. Steven Roosevelt, MD, PhDAffiliations: Idaho Diabetes and Endocrine Associates; Boise, ID 83702 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 November 1995Volume 123, Issue 10Page: 813-814KeywordsCrimeDeath ratesFirearm injuriesHomicide ePublished: 15 August 2000 Issue Published: 15 November 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A communitywide perspective of sex differences and temporal trends in the incidence and survival rates after acute myocardial infarction and out-of-hospital deaths caused by coronary heart disease.
Authors: R JGoldberg, E JGorak, JYarzebski, D WHosmer, PDalen, J MGore, J SAlpert, J EDalen
Journal: Circulation (1993)

BACKGROUNDThe purpose of the study was to examine overall differences and temporal trends therein between men and women regarding the incidence rates, in-hospital and long-term survival after initial acute myocardial infarction (AMI), and out-of-hospital deaths caused by coronary disease.METHODS AND RESULTSThis nonconcurrent prospective study was carried out in 16 teaching and community hospitals in Worcester, Mass., in six time periods between 1975 and 1988. A total of 3,148 patients hospitalized with validated initial AMI comprised the study sample. The age-adjusted incidence rates of initial AMI increased between 1975 and 1981 in the two sexes, with a marked decrease thereafter; these rates declined by 26% in men and by 22% in women between 1975 and 1988. The overall unadjusted in-hospital case-fatality rates after initial AMI were significantly higher in women (21.7%) than in men (12.7%). Age- and multivariable-adjusted in-hospital case-fatality rates, however, were not significantly different for men...
Myocardial fiber diameter and regional distribution in the ventricular wall of normal adult hearts, hypertensive hearts and hearts with hypertrophic cardiomyopathy.
Authors: THoshino, HFujiwara, CKawai, YHamashima
Journal: Circulation (1983)

Myocardial fiber diameters were measured to determine their distribution throughout the ventricular wall in normal adult hearts, hypertensive hearts and hearts with hypertrophic cardiomyopathy (HCM). In normal adult hearts and hypertensive hearts, the diameter decreased from the inner to the outer third of the left ventricular free wall and from the left ventricular side to the right ventricular side of the septum. In HCM, these regional differences were preserved in the left ventricular free wall, but not in the septum. The diameter was greatest in the middle third of the septum, where myocardial fiber disarray was widely distributed. The diameters of the fibers in the right ventricular side of the septum were significantly larger than those of the fibers in the left ventricular side of the septum in HCM. This finding, in contrast to that in normal adult hearts or hypertensive hearts, was considered to be related to the inward convex curvature of the left ventricular chamber. Although there was no signif...
Effect of vagal stimulation on the overflow of norepinephrine into the coronary sinus during cardiac sympathetic nerve stimulation in the dog.
Authors: M NLevy, BBlattberg
Journal: Circulation Research (1976)

In anesthetized dogs with the chest open, supramaximal stimulation of the left cardiac sympathetic nerves at 2 and 4 Hz produced an increase of 40-50% in ventricular contractile force (CF) and of 40-65% in coronary sinus blood flow. At these frequencies of stimulation, norepinephrine (NE) overflow into the coronary sinus was 29.8 +/- 5.1 (SE) and 54.9 +/- 13.2 ng/min, respectively. Concurrent, supramaximal vagal stimulation, at a frequency of 15 Hz, had no significant effect on coronary sinus blood flow, but caused a 25% reduction in CF and a 30% decrease in NE overflow. The changes in CF and NE overflow evoked by vagal stimulation were prevented by atropine. These results are consistent with the hypothesis that there are muscarinic receptors on the postganglionic sympathetic terminals in the walls of the ventricles. Acetylcholine released during vagal stimulation combines with these receptors, causes a reduction in the liberation of NE, and thereby attenuates the positive inotropic response.
Preservation of endothelial cell structure and function by intracoronary perfluorochemical in a canine preparation of reperfusion.
Authors: M BForman, D WPuett, S EBingham, RVirmani, M VTantengco, R TLight, ABajaj, RPrice, GFriesinger
Journal: Circulation (1987)

To determine the effect of intracoronary perfluorochemical on endothelial cell structure and function, 16 dogs were randomized to receive either low-dose (15 ml/kg) intracoronary perfluorochemical (Fluosol-DA) or saline after 90 min of proximal occlusion of the left anterior descending coronary artery (LAD). The animals underwent reperfusion for 60 min with the introduction of perfluorochemical or saline 5 to 10 min after the onset of reperfusion. Endothelium-dependent coronary vasodilatory reserve was determined in vivo both at baseline and 1 hr after reperfusion by infusion of acetylcholine and then serotonin into the distal LAD bed in 12 animals (six in each group). Both agonists significantly increased regional flow measured by 133Xe washout in the two groups before occlusion, but at 1 hr after reperfusion only animals given perfluorochemical demonstrated a significant increase in flow. Vasodilatory reserve was assessed in vitro with cumulative dose-response curves to acetylcholine on LAD rings proxim...