tbuckley/cabot-search huggingface dataset:
Age‐ and sex‐adjusted prevalence estimates among paediatric patients with psoriasis in the United States
Authors: Rachel Tannenbaum, Andrew Strunk, Amit Garg
Journal: British Journal of Dermatology (2022)

Dear Editor, The Centers for Disease Control Public Health Agenda for Psoriasis and Psoriatic Arthritis identified gaps in our understanding of disease burden among children and adolescents. Accurate estimates for overall and subgroup prevalences of psoriasis in paediatric populations are critical for supporting therapeutic development, risk assessment for comorbidities and resource allocation. To estimate prevalence of paediatric psoriasis in the USA, we performed a cross‐sectional analysis in Explorys, a health records database comprising more than 60 million patients from over 40 healthcare networks across all census regions. Using a case definition of at least two diagnosis codes (positive predictive value 76–79%), we identified prevalent cases among active nondeceased patients aged 0–17 years between August 2019 and August 2020. Those missing age or sex information were excluded. Estimates were standardized according to the direct method using the 2010 US Census population as the reference. Standardized prevalences were age‐adjusted for sex comparisons, sex‐adjusted for age‐group comparisons, and sex‐ and age‐adjusted for race‐group comparisons. Confidence intervals (CIs) for crude and standardized prevalences were calculated based on the Wilson score method and gamma distributions, respectively.
THE PATHOGENESIS OF PARALYSIS AGITANS.
Journal: JAMA (1901)

Although the symptomatology of paralysis agitans has been very thoroughly described, the pathogenesis of the disease is still involved in considerable obscurity. The affection occurs especially in advanced life, and such lesions as have been discovered after death correspond essentially with those of senility. It is true, cases are sometimes observed in comparatively young individuals, and in these the disorder is attributed to the premature development of the senile changes. The cardinal symptoms are rhythmic tremor, and muscular weakness and rigidity. The etiology of the disorder is not definitely known, although the symptoms have at times been observed to appear in a part of the body that has been subject to traumatism or to strain. They have also been seen to follow exposure to cold, or in the train of acute infectious diseases. Of late it has been suggested by some observers that paralysis agitans is dependent upon disease of
Medical News
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Studies of the Carcinogenic Action in the Rat of 2-Nitro-, 2-Amino-, 2-Acetylamino-, and 2-Diacetylaminofluorene after Ingestion and after Painting&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1950)

Studies of the Carcinogenic Action in the Rat of 2-Nitro-, 2-Amino-, 2-Acetylamino-, and 2-Diacetylaminofluorene after Ingestion and after Painting Get access Harold P. Morris, Harold P. Morris Search for other works by this author on: Oxford Academic PubMed Google Scholar Celia S. Dubnik, Celia S. Dubnik Search for other works by this author on: Oxford Academic PubMed Google Scholar James M. Johnson James M. Johnson National Cancer Institute, National Institutes of Health, Public Health Service, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 6, June 1950, Pages 1201–1213, https://doi.org/10.1093/jnci/10.6.1201 Published: 01 June 1950 Article history Received: 30 January 1950 Published: 01 June 1950
Amoebiasis
Authors: F. T. Page
Journal: BMJ (1946)

BREDICAL JOUNAL 1005immediate adhesions from forming between the anterior and posterior wounds.(4) When removed it carries away.with it any blood or clots that may be lying in the vagina.(5) It pre- vents urine from running into the vagina.There is special liability for this to happen when a patient is lying on her back.From the very beginning of the first week in bed the patient is encouraged to move the lower limbs, especially the ankle joints, freely in order to obviate the risk of venous stasis with the possibility of clotting and embolism.Patients are kept lying in bed after operation, without once raising themselves or being raised, for two weeks.During the third week they are free to sit up in bed.At the end of three weeks they get up.A few days later they are allowed home, but are given special instructions as to carefulness about refraining from any undue strains for the next two months.Before leaving hospital they are examined, a finger being inserted into the vagina so that any small plastic adhesion between anterior and posterior wounds may be broken down.Two months after leaving hospital the patient reports for a final examination so that the result may be assessed.I have found that this routine has given excellent results and it is quite simple to carry out as far as the nursing is concerned.-Iam, etc., Dundee.
More attention paid to prostate cancer research
Authors: P. Gunby
Journal: JAMA (1997)

IF YOU think you've been hearing a lot about adenocarcinoma of the prostate lately, just wait until 1998. In addition to a growing amount of research into the causes, detection, prevention, and treatment of prostate cancer, increasing public attention is focusing on the disease. Representatives of the American Cancer Society (ACS), Centers for Disease Control and Prevention, and National Prostate Cancer Coalition (NPCC) in recent days have been discussing "consumer involvement" in prostate cancer awareness and its research funding. The NPCC, entering its second year as a gathering of groups throughout the United States that are interested in this disease, now has offices in Washington, DC. Its first executive officer, Jay Hedlund, formerly with the Children's Defense Fund and Common Cause, was introduced to many in the prostate cancer research community this fall at the Fourth Annual Scientific Retreat at Lake Tahoe, Nev, of the Association for the Cure of
The Academic Medical Center and the Health of the Public
Authors: Geoffrey Wittig
Journal: JAMA (1992)

<h3>To the Editor.</h3> —I read with interest your recent Health of the Public<sup>1</sup>Special Communication in the May 13 issue regarding the future of the academic medical center. The challenge posed by the current model's failure to deal with the most intractable social/medical problems is indeed formidable. I applaud at least the recognition that there is a problem! All the same, I am struck by the ponderous and "institutional" solutions offered by the Health of the Public Program. There is clearly a simpler and better solution. Virtually all of the problems with the current model so well elucidated in the opening paragraphs (inattention to vexing chronic care problems, astronomical costs, lack of access to care, poor specialty and geographic distribution of physicians) have the same root cause. The academic medical center "culture" has for decades controlled the direction of medical education. The result has been an accelerating imbalance between
Expression of p53 protein isoforms predicts survival in patients with multiple myeloma
Authors: Elizabeta A. Rojas, Luis A. Corchete, Cristina De Ramón, Patryk Krzeminski, Dalia Quwaider, Ramón García‐Sanz, Joaquín Martínez‐López, Albert Oriol, Laura Rosiñol, Joan Bladé, Juan José Lahuerta, Jesús F. San Miguel, Marcos González, María Victoria Mateos, Jean‐Christophe Bourdon, Irena Misiewicz‐Krzeminska, Norma C. Gutiérrez
Journal: American Journal of Hematology (2022)

Loss and/or mutation of the TP53 gene are associated with short survival in multiple myeloma, but the p53 landscape goes far beyond. At least 12 p53 protein isoforms have been identified as a result of a combination of alternative splicing, alternative promoters and/or alternative transcription site starts, which are grouped as α, β, γ, from transactivation domain (TA), long, and short isoforms. Nowadays, there are no studies evaluating the expression of p53 isoforms and its clinical relevance in multiple myeloma (MM). We used capillary nanoimmunoassay to quantify the expression of p53 protein isoforms in CD138-purified samples from 156 patients with newly diagnosed MM who were treated as part of the PETHEMA/GEM2012 clinical trial and investigated their prognostic impact. Quantitative real-time polymerase chain reaction was used to corroborate the results at RNA levels. Low and high levels of expression of short and TAp53β/γ isoforms, respectively, were associated with adverse prognosis in MM patients. Multivariate Cox models identified high levels of TAp53β/γ (hazard ratio [HR], 4.49; p < .001) and high-risk cytogenetics (HR, 2.69; p < .001) as independent prognostic factors associated with shorter time to progression. The current cytogenetic-risk classification was notably improved when expression levels of p53 protein isoforms were incorporated, whereby high-risk MM expressing high levels of short isoforms had significantly longer survival than high-risk patients with low levels of these isoforms. This is the first study that demonstrates the prognostic value of p53 isoforms in MM patients, providing new insights on the role of p53 protein dysregulation in MM biology.
Dexamethasome Myopathy
Authors: D. N. Golding, T. B. Begg
Journal: BMJ (1960)

Evidence is presented that desensitization to cholinergic agonists in chick and leech muscle is a process involving receptor inactivation. Various possible mechanisms that could account for slow inactivation of receptors by agonists were analyzed mathematically, and expressions were obtained for the rate and extent of desensitization expected under various conditions. With the majority of agonists tested there appeared to be the same relationship between the response and the amount of desensitization produced. Certain agonists, however, were relatively more effective in causing desensitization. The kinetics of development of and recovery from desensitization were studied in chick and frog muscle. Reactivation of desensitized receptors occurred exponentially. In chick muscle the rate constant for recovery was the same (0.3 min<sup>-1</sup>) regardless of what agonist had been used to produce the desensitization. In chick muscle, tubocurarine decreased <i>pari passu</i> the response and the desensitization produced by carbachol or suxamethonium. Tubocurarine increased the desensitization produced by the partial agonist <i>n</i>-decyltrimethylammonium. These results are compatible with the cyclic model for desensitization suggested by Katz and Thesleff [<i>J. Physiol.</i> (<i>London</i>) 138, 63 (1957)], with the additional factor that certain drugs may have a preferential affinity for desensitized, compared with normal, receptors. The process of receptor activation may be very closely related to the transition from normal to desensitized receptors brought about by agonist drugs.
Levamisole in rheumatoid arthritis. Final report on a randomised double-blind study comparing a single weekly dose of levamisole with placebo. Multicentre Study Group.
Authors: R Adam, E Bernardiner, A Bieller, E Veys, H Germany, G Great Britain, E Huskisson, Miss Scott, D Felix-Davies, B Ireland, P Donnelly, D Switzerland, M Rosenthal, T Vischer, H Ott, J Gerster, R Usa, S Brobyn, J Symoens, Janssen Pharmaceutica
Journal: Annals of the Rheumatic Diseases (1982)

The therapeutic effect of a single weekly dose of levamisole in patients with rheumatoid arthritis was compared with placebo for 6 months in a 13-centre double-blind controlled study. 281 patients with classic or definite rheumatoid arthritis and active disease were evaluated. A single weekly dose of 150 mg levamisole was superior to placebo in controlling disease activity. A single weekly dose of 50 mg levamisole had an intermediate effect. Adverse reactions occurred in approximately 40% of the patients with 150 mg levamisole and in approximately 20% of the patients with 50 mg levamisole or placebo. In comparison with the classical dosage schedule of levamisole (150 mg on 3 consecutive days each week) a single weekly dose of 150 mg levamisole was found to be slightly less effective but much better tolerated.
AMAGRAMS
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ankylosing spondylitis.
Authors: K. W. Mills
Journal: BMJ (1968)

I personally deplore the practice of breast augmentation by injection of foreign material with its attendant risk of masking the appearance of a carcinoma; this, however, is not a valid reason for condemning the silicones, which, if properly used in pure form and carefully handled to avoid contamination, are extraordinarily inert and may prove to be the most useful and safest of the implant materials we have at our disposal.-Iam, etc.,
JOURNALISTIC NOTES.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Advanced Gynecologic Endoscopic Surgery—Laser and Nonlaser Techniques
Journal: JNCI Journal of the National Cancer Institute (1987)

Advanced Gynecologic Endoscopic Surgery—Laser and Nonlaser Techniques Get access JNCI: Journal of the National Cancer Institute, Volume 78, Issue 6, June 1987, Page 1253, https://doi.org/10.1093/jnci/78.6.1253-b Published: 01 June 1987
Comprehensive care.
Authors: J. A. Anderson, P. Draper
Journal: BMJ (1968)

approach, his curve was 90'.Thus, three spines out of a group of 60 with a similar condition were distorted by a hiatus hernia box, and all three are among the small pro- portion (7 out of 60) who failed to resolve without demonstrable cause within 18 months.It is possible that prolonged " sitting " in the box acted against resolution of the curve.Whilst treating hiatus hernia in an infant one has no attractive alternative to using the box, but its use in normal children, which is becoming increasingly popular, should be watched.-Iam, etc.,
Food In Health and Disease.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE DANGER OF GENERALIZED MEDICAL TERMS
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Enteric Pneumatosis
Authors: F. J. C. Matthews
Journal: BMJ (1954)

iRt'riSH, 851 equilibrium between growth, activity, and appetite is set at a low level, owing to some factor affecting the last of these.Whether " undernutrition " of this nature could affect growth without effect on the surface fat, or with such small changes only as we have reported, is unknown; it is not the sole, and may not even be the prime, function of the surface fat exactly to make good deficits of intake.There are, as already noted, long-term growth studies in progress, some of them on the general public.The prac- tical value of these will depend in part upon the success with which the factors affecting growth are recognized at the time and their intensity is gauged.This is impossible in the case of non-dietary factors without working hypotheses regarding their modus operandi.Hence these considerable speculations.We would suggest, among such hypotheses, that such things as a varied and tempting diet, adequate sleep, and regular bowel habits, and similar attention to the fitness of the child, may affect appetite and therefore growth rate.
MOTOR NOTES FOR MEDICAL MEN
Authors: H. M. Buist
Journal: BMJ (1922)

WHEREAS the majority of the passenger cars shown at the recent exhibition in Paris were the identical vehicles that appeared in the same building twelve months ago, in the case of the sixteenth International Passenger-Car Show that opened on Friday, November 3rd, under the patronage of the King, at Olympia, Kensington, and the White City, Shepherd's Bush, London, there is practically not one vehicle, or chassis, staged which appeared last year.Though split into two buildings, as in Paris, the display in London differs from the French inasmuch as the latter contained pedal bicycles, motor bicycles, commercial motors, and marine motors, as well as motor cars and all manner of accessories, whereas the British one is confined solely to passenger cars and accessories for them.The exhibition in London, which will be open until Saturday, Novemnber 11th, is, too, of a more international character than the French exhibition, and much more so than any of the American shows, or than the German and other displays on the continent of Europe.All cars of note introduced to the public in Paris are shown in London, and the American industry is represented by nearly all its notable products none of the few abstainers have new models of note embody- ing fresh ideas in regard to construction.By way of indicating at once the sheer variety of fresh material for consideration, I may, mention that quite new models are introduced by the following firms among others:
SOCIETY NEWS AND ANNOUNCEMENTS
Authors: Oliver Bögler, Pam Sutton
Journal: Neuro-Oncology (2004)

This course will bring international experts together to discuss cutting-edge concepts and techniques in neurooncology.Didactic lectures, case presentations, and panel discussions will provide a fast-paced and interactive forum in a state-of-the-art presentation theater.Neurosurgeons, neurologists, medical oncologists, radiation oncologists, neuropathologists, neuroradiologists, and oncology basic science researchers will benefit from useful information that will impact daily practice.A concurrent program covering neuro-oncology topics for clinical nurses will also be included.Nurses from both the hospital and office practice setting will benefit from presentations geared toward daily practice.