tbuckley/cabot-search huggingface dataset:
Coronary anatomy and left ventricular function in the first 12 hours of acute myocardial infarction: the Western Washington Randomized Intracoronary Streptokinase Trial.
Authors: M LStadius, CMaynard, J KFritz, KDavis, J LRitchie, FSheehan, J WKennedy
Journal: Circulation (1985)

The relationships among clinical variables, coronary anatomy, and left ventricular function during the early hours of acute myocardial infarction (AMI) were evaluated from data acquired in the Western Washington Intracoronary Streptokinase Trial. All patients had symptoms and electrocardiographic changes typical of AMI. All data were obtained before treatment with streptokinase. Mean time to catheterization was 4.1 hr after onset of symptoms. Coronary angiograms (n = 245) were analyzed for location of infarct-related occlusion and collateral flow to the infarct bed. Left ventricular ejection fraction and regional left ventricular function were quantitated in 227. Sixty-two percent of occlusions were in the most proximal segment of the involved coronary artery. Collateral circulation was seen in 42% overall, in 31% with left anterior descending artery (LAD) occlusion, and in 52% with right coronary artery (RCA) occlusion (p less than .005). Left ventricular ejection fraction was lowest and regional functio...
Drainage of right superior vena cava into both atria. Review of the literature and description of a case presenting with polycythemia and paradoxical embolization.
Authors: E PShapiro, JAl-Sadir, N PCampbell, O GThilenius, C EAnagnostopoulos, PHays
Journal: Circulation (1981)

An unusual cause of polycythemia, cyanosis and paradoxical embolus is described in a 37-year-old man, consisting of a rare congenital anomaly of the superior vena cava (SVC). The right-sided SVC received pulmonary venous drainage from the right lung and drained, through two channels, into both atria with the left atrium receiving the larger of the two channels. The atrial septum was intact. Corrective surgery and postoperative cardiac catheterization are described and the literature concerning anomalies of the right superior vena cava is reviewed.
Structure, function and inhibition of critical protein–protein interactions involving mixed lineage leukemia 1 and its fusion oncoproteins
Authors: Xin Li, Yongcheng Song
Journal: Journal of Hematology & Oncology (2021)

Abstract Mixed lineage leukemia 1 (MLL1, also known as MLL or KMT2A) is an important transcription factor and histone-H3 lysine-4 (H3K4) methyltransferase. It is a master regulator for transcription of important genes (e.g., Hox genes) for embryonic development and hematopoiesis. However, it is largely dispensable in matured cells. Dysregulation of MLL1 leads to overexpression of certain Hox genes and eventually leukemia initiation. Chromosome translocations involving MLL1 cause ~ 75% of acute leukemia in infants and 5–10% in children and adults with a poor prognosis. Targeted therapeutics against oncogenic fusion MLL1 (onco-MLL1) are therefore needed. Onco-MLL1 consists of the N-terminal DNA-interacting domains of MLL1 fused with one of &gt; 70 fusion partners, among which transcription cofactors AF4, AF9 and its paralog ENL, and ELL are the most frequent. Wild-type (WT)- and onco-MLL1 involve numerous protein–protein interactions (PPI), which play critical roles in regulating gene expression in normal physiology and leukemia. Moreover, WT-MLL1 has been found to be essential for MLL1-rearranged (MLL1-r) leukemia. Rigorous studies of such PPIs have been performed and much progress has been achieved in understanding their structures, structure–function relationships and the mechanisms for activating gene transcription as well as leukemic transformation. Inhibition of several critical PPIs by peptides, peptidomimetic or small-molecule compounds has been explored as a therapeutic approach for MLL1-r leukemia. This review summarizes the biological functions, biochemistry, structure and inhibition of the critical PPIs involving MLL1 and its fusion partner proteins. In addition, challenges and perspectives of drug discovery targeting these PPIs for the treatment of MLL1-r leukemia are discussed.
Transferable lipids in oxidized low-density lipoprotein stimulate plasminogen activator inhibitor-1 and inhibit tissue-type plasminogen activator release from endothelial cells.
Authors: KKugiyama, TSakamoto, IMisumi, SSugiyama, MOhgushi, HOgawa, MHoriguchi, HYasue
Journal: Circulation Research (1993)

Decreased fibrinolytic activity has been reported in atherosclerotic cardiovascular diseases. To determine whether oxidized low-density lipoprotein (Ox-LDL), which accumulates in atherosclerotic arteries, modulates the endothelial fibrinolytic system, cultures of human umbilical vein endothelial cells were incubated with low-density lipoproteins or lipids, and levels of plasminogen activator inhibitor-1 (PAI-1) and tissue-type plasminogen activator (t-PA) antigens in the conditioned medium were measured by enzyme-linked immunosorbent assay. Ox-LDL (30 micrograms protein/mL) and its extracted lipid (50 micrograms cholesterol/mL) stimulated PAI-1 release by 42 +/- 3% and 29 +/- 3% of control cultures, respectively, whereas Ox-LDL and its lipid inhibited t-PA release by 42 +/- 4% and 53 +/- 3% of control cultures, respectively. Native LDL and its lipid were inactive on their release. Ox-LDL depleted of hydrophilic lipids, which was prepared by the incubation with defatted albumin (an acceptor for hydrophilic...
Lipid lowering and plaque regression. New insights into prevention of plaque disruption and clinical events in coronary disease.
Authors: B GBrown, X QZhao, D ESacco, J JAlbers
Journal: Circulation (1993)

The consensus of evidence from angiographic trials demonstrates both coronary artery and clinical benefits from lowering of lipids by a variety of regimens. The findings of reduced arterial disease progression and increased regression have been convincing but, at best, modest in their magnitude. For example, among those treated intensively in FATS, the mean improvement in proximal stenosis severity per patient was < 1% stenosis, and only 12% of all lesions showed convincing regression. In view of these modest arterial benefits, the associated reductions in cardiovascular events have been surprisingly great. For example, coronary events were reduced 75% in FATS; this was entirely a result of a 93% reduction in the likelihood that a mildly or moderately diseased arterial segment would experience substantial progression to a severe lesion at the time of a clinical event. We believe that the magnitude of the clinical benefit is best explained in terms of this observation, according to the following lines of r...
Evidence for distinct calcium channel agonist and antagonist binding sites in intact cultured embryonic chick ventricular cells.
Authors: R TLee, T WSmith, J DMarsh
Journal: Circulation Research (1987)

To determine whether calcium channel agonists and antagonists bind to distinct pharmacologically active sites, the binding of dihydropyridine calcium channel agonists and antagonists was related to calcium flux and contractile state in primary monolayer cultures of spontaneously contracting chick embryo ventricular cells. Equilibrium binding studies using the antagonist (+)-[3H]PN200-110 demonstrated equilibrium binding to intact, beating cells consistent with a single class of binding sites (KD, 1.1 nM; Bmax, 40 fmol/mg protein). Membrane depolarization of the intact cells by incubation in 30 mM potassium caused a 91% increase in the apparent number of (+)-PN200-110 binding sites (Bmax 76 fmol/mg protein), but no significant change in the KD (1.2 nM). The (+)-PN200-110 produced a concentration-dependent decrease in calcium uptake (IC50 2.2 nM) and contractile amplitude (IC50 5.6 nM). The calcium channel agonist, (+/-)-[3H]BAY k 8644, bound to two distinct binding sites with high affinity (KD 1.0 nM) and ...
Immunohistochemical localization of basic and acidic fibroblast growth factors in the developing rat heart.
Authors: PSpirito, Y MFu, Z XYu, S EEpstein, WCasscells
Journal: Circulation (1991)

BACKGROUNDWe used biochemical and immunohistochemical techniques to investigate the expression and distribution of immunoreactive basic and acidic fibroblast growth factors (bFGF and aFGF, respectively) in the hearts of rat embryos (11-20 days of gestation) and of postnatal rats (1-35 days after birth). Our purpose was to assess the relation between the cellular distribution of these growth factors and histogenetic and morphogenetic events in the developing heart.METHODS AND RESULTSWestern-blot analysis of heparin-bound material from neonatal heart extracts identified a single band with a molecular weight of approximately 18 kD for both bFGF and aFGF. Five antibodies for bFGF and three for aFGF showed superimposable distribution of immunoreactive bFGF and aFGF in the heart at each stage examined. At the cellular level, these peptides were localized in the cytoplasm and extracellular matrix. In the myocytes, immunostaining was positive throughout the embryonic and neonatal periods. In the majority of the m...
Improvement in symptoms and left ventricular performance after balloon aortic valvuloplasty in patients with aortic stenosis and depressed left ventricular ejection fraction.
Authors: R DSafian, S EWarren, A DBerman, D JDiver, L LMcKay, P CCome, WGrossman, R GMcKay
Journal: Circulation (1988)

The application of balloon aortic valvuloplasty to elderly patients with severe aortic stenosis and a low ventricular ejection fraction is undefined. Balloon aortic valvuloplasty was performed in a subset of 28 patients with low left ventricular ejection fraction (37 +/- 11%), severe aortic stenosis, and a mean age of 79 +/- 5 years. After valvuloplasty, significant increases were seen in aortic valve area (from 0.5 +/- 0.1 to 0.9 +/- 0.2 cm2), aortic systolic pressure (from 120 +/- 12 to 135 +/- 22 mm Hg), and cardiac output (from 4.2 +/- 1.1 to 4.8 +/- 1.6 l/min) (p less than 0.01), and significant decreases were seen in transaortic pressure gradient (from 69 +/- 25 to 35 +/- 15 mm Hg) and pulmonary capillary wedge pressure (from 24 +/- 9 to 20 +/- 7 mm Hg) (p less than 0.01). All patients had symptomatically improved at the time of discharge. Serial radionuclide ventriculography showed an increase in left ventricular ejection fraction from 37 +/- 11% before valvuloplasty to 44 +/- 14% within 48 hours a...
BK Viremia in Kidney Transplant Recipients
Authors: Gopal Basu, Margabandhu Saravanan, Anjali Mohapatra, Anna T Valson, Vinoi G David, Suceena Alexander, Shibu Jacob, Santosh Varughese, Chakko K Jacob, Veerasamy Tamilarasi
Journal: Journal of the American Society of Nephrology (2013)
Increased circulating bradykinin during hypothermia and cardiopulmonary bypass in children.
Authors: L MPang, S AStalcup, J SLipset, C JHayes, F OBowman, R BMellins
Journal: Circulation (1979)

To determine whether cold could activate the kallikrein-kinin system in vivo as it does in vitro, the circulating systemic concentrations of bradykinin were serially measured in 10 cyildren with congenital diseases of the heart undergoing corrective cardiac surgery. Bradykinin was measured by radioimmunoassay in blood samples obtained before, during and after profound hypothermia (to 18 degrees C) and cardiopulmonary bypass. The circulating concentrations of bradykinin increased significantly as body temperature decreased during surface cooling. The increase in circulating bradykinin was associated with a decrease in the circulating level of bradykininogen, the precursor of bradykinin. With the onset of cardiopulmonary bypass and hence, removal of the lung and pulmonary converting enzyme from the circulation, there was a further rise in the already elevated concentrations of bradykinin. This is the first in vivo demonstration that hypothermia leads to an increase in the circulating concentrations of brady...
Quantitative thallium-201 redistribution with a fixed coronary stenosis in dogs.
Authors: JLeppo, JRosenkrantz, RRosenthal, RBontemps, TYipintsoi
Journal: Circulation (1981)

The redistribution of thallium-201 (201Tl) after coronary vasodilation was studied in 14 dogs with a proximal stenosis of the left circumflex coronary artery that did not reduce basal flow but attenuated reactive hypermia. During an 8-10-minute i.v. infusion of adenosine, radioactive microspheres and 201Tl were injected into the left atrium. Sequential cardiac scintiscans and microsphere injections permitted subsequent determination of coronary blood flow during the redistribution of 201Tl. After 15-220 minutes of observation, the dogs were killed and the hearts removed for the measurement of the activity of 201Tl and the radioactive microspheres in the normal (left anterior descending coronary artery [LAD]) and flow-restricted (left circumflex coronary artery [LCX]) regions. The ratios of the activity in LAD/LCX for microspheres (TRmic) and for 201Tl (RT1) were compared with the activity ratio determined from the scintiscan (Rscan). Rmic for the microsphere simultaneously injected with 201Tl can be compa...
Intracellular divalent cations block smooth muscle K+ channels.
Authors: C HGelband, TIshikawa, J MPost, K DKeef, J RHume
Journal: Circulation Research (1993)

The patch-clamp technique was used to examine the sensitivity of delayed rectifier K+ channels to changes in intracellular divalent cations (Mg2+ and Ca2+). During voltage-step and ramp depolarizations, a delayed rectifier K+ current (IK(dr)) was identified in renal, pulmonary, coronary, and colonic smooth muscle cells as a low-noise outward current that activated near -40 mV, was sensitive to 4-aminopyridine (4-AP), and was insensitive to charybdotoxin. During whole-cell voltage-clamp experiments in each of the cell types, the 4-AP-sensitive IK(dr) was significantly less in cells dialyzed with 10 mM Mg2+ as compared with cells in which no Mg2+ was added to the internal dialysis solution (P   or = 4). In coronary artery cells, 100 microM 2-(2-aminoethyl)pyridine (an H1 receptor agonist) or 10 microM ryanodine, agents that cause an increase in [Ca2+]i, also caused a significant reduction of the 4-AP-sensitive IK(dr) similar to that produced by Mg2+. 4-AP (5 mM) significantly depolarized singl...
In vitro adrenergic and cholinergic innervation of the developing rat myocyte.
Authors: W JMarvin, D LAtkins, V LChittick, D DLund, KHermsmeyer
Journal: Circulation Research (1984)

We studied the development of selective adrenergic and cholinergic neuroeffector transmission in primary cultures of isolated ventricular muscle cells. Explants of either thoracolumbar sympathetic ganglia or sacrococcygeal spinal cord were added to newborn rat ventricular cultures harvested prior to the onset of in vivo autonomic innervation. Neuronal growth, migration, and the formation of neuromuscular junctions were observed with light and scanning electron microscopy. Glyoxylic acid histofluorescence, reflecting catecholamine synthesis, was found in only the sympathetic neuromuscular cultures. Choline acetyltransferase activity was detected in both spinal cord and sympathetic neuromuscular cultures, but was significantly higher in the spinal cord neuromuscular cultures. The isolated ventricular muscle cells remained at a constant spontaneous contraction frequency, regardless of the type of culture preparation. Guanethidine sulfate application produced a positive chronotropic response, blocked by propr...
Correlation between template bleeding times and spontaneous bleeding during treatment of acute myocardial infarction with recombinant tissue-type plasminogen activator.
Authors: L WGimple, H KGold, R CLeinbach, B SColler, WWerner, TYasuda, J AJohns, A AZiskind, DFinkelstein, DCollen
Journal: Circulation (1989)

The purpose of this study was to correlate bleeding complications during and after treatment with recombinant tissue-type plasminogen activator (rt-PA) with serial template bleeding time measurements, with ADP-induced platelet aggregation, with clinical characteristics, and with hemostatic parameters. Fifty-two of 55 consecutive patients with acute myocardial infarction and template bleeding times (Ivy method) of less than 9.5 minutes were treated with rt-PA in a total dose of 55-212 mg (mean, 109 mg) over 90 to 360 minutes (median, 240 minutes) combined with heparin. The mean bleeding time was significantly prolonged at 90 minutes (from 5.0 +/- 1.9 to 8.2 +/- 4.3 minutes, p less than 0.0001) but returned toward baseline after 4 hours (from a median of 8.0 to 7.0 minutes, p less than 0.05). Thirteen patients (25%) suffered relatively minor but spontaneous bleeding that did not correlate with age, hypertension, smoking, partial thromboplastin time, platelet count, ADP-induced platelet aggregation, steady-s...
Mitral Valve Remodeling and Strain in Secondary Mitral Regurgitation
Authors: K. Carlos El-Tallawi, Peng Zhang, Robert Azencott, Jiwen He, Jiaqiong Xu, Elizabeth L. Herrera, Jessen Jacob, Mohammed Chamsi-Pasha, Gerald M. Lawrie, William A. Zoghbi
Journal: JACC. Cardiovascular imaging (2021)
Special Experience or Service
Authors: G. Scott
Journal: BMJ (1966)

MBwcHJo from 4 to 12 years ; the great majority had failed to respond to other treatment.The practice has been to record at the initial examination the frequency, severity, and duration of attacks, as described by the parent.The child and the parent are instructed in diaphragmatic breathing and basal expansion.The case is reviewed at the end of the first or second month, according to severity ; in the interval child and parent receive instruction twice weekly at hospital and are exhorted to practise at least once a day at home.
Re : van Dijk et al.: Half-dose photodynamic therapy versus high-density subthreshold micropulse laser treatment in patients with chronic central serous chorioretinopathy: the PLACE trial (Ophthalmology. 2018;125:1547-1555) Reply
Authors: E.H.C. van Dijk, S. Fauser, M.B. Breukink, R. Blanco-Garavito, J.M.M. Groenewoud, J.E.E. Keunen, P.J.H. Peters, G. Dijkman, E.H. Souied, R.E. Maclaren, G. Querques, S.M. Downes, C.B. Hoyng, C.J.F. Boon
Journal: Ophthalmology (2019)
Recording of diastolic slope from the junctional area in dogs with junctional rhythm.
Authors: R JHariman, C MChen
Journal: Circulation (1983)

Stable junctional rhythm was induced in 14 of 25 anesthetized dogs by exclusion of the sinus node and surrounding atrial tissue. In 12 of the 14 dogs diastolic slope was recorded through a unipolar lead consisting of a terminal of a plunge or catheter electrode placed in the His bundle area coupled with an indifferent superior vena caval electrode. Reversed polarity, high-gain amplification (0.1 mV/cm), and low-pass filters (0.1 to 50 Hz) were used for the unipolar recording. The diastolic slope (0.15 +/- 0.07 mV/sec) was recorded from a localized area close to the His bundle and preceded the bipolar His bundle deflection. Overdrive atrial stimulation was followed by slowing of the junctional rate and decrease in the diastolic slope. A strong negative correlation (r values from -.78 to -.95) was found between the junctional cycle lengths and the diastolic slopes after atrial pacing. Isoproterenol infusion increased the junctional rate and the diastolic slope, whereas vagal stimulation and verapamil inject...
Angiographic-pathologic correlations after elective percutaneous transluminal coronary angioplasty.
Authors: TNaruko, MUeda, A EBecker, OTojo, MTeragaki, KTakeuchi, TTakeda
Journal: Circulation (1993)

BACKGROUNDThe local effect of coronary angioplasty is evaluated on the basis of postangioplasty angiograms. Smooth-walled dilation is considered to represent minimal or no injury, whereas intraluminal haziness corresponds with wall laceration. This study correlates the preangioplasty and postangioplasty angiograms with the histopathology of the target sites.METHODS AND RESULTSThe study includes 12 patients, each undergoing an elective procedure, and covers 19 angioplasty sites. Smooth-walled dilation and intraluminal haziness were not mutually exclusive. The angiograms were interpreted as smooth-walled dilation (n = 3), smooth-walled dilation with intraluminal haziness (n = 4), intraluminal and extraluminal haziness (n = 5), extraluminal dissection (n = 5), spiraltype dissection (n = 1), and aneurysm (n = 1). The histology of the arterial segments revealed wall laceration in all. Smooth-walled dilation without intraluminal haziness correlated with laceration limited to the intima in two, but with medial i...
The Impact Of Sars-Cov-2 On The Irish National Colorectal Cancer Screening Programme: A Report From Two High-Volume Endoscopy Centres
Authors: E Ring, C Conlon, H Kerr, J O’Grady, S Devlin, S Stewart, J Leyden, G Cullen, G Horgan, J Sheridan, H Mulcahy, M Buckley, P MacMathuna, G Doherty, C Lahiff
Journal: Endoscopy (2021)

Aims The Irish National BowelScreen programme paused activities in March 2020 to prioritise the emergency response to the SARS-CoV-2 pandemic. As a result, patients with positive fecal immunochemical test (FIT) results that had already been returned, experienced delays in time to colonoscopy. The standard lead time in BowelScreen is 20 working days. The aim of this study was to examine the impact of this delay on time to colonoscopy for index FIT positive cases in two tertiary endoscopy units.
Comment on Duran et al. Introduction of IADPSG Criteria for the Screening and Diagnosis of Gestational Diabetes Mellitus Results in Improved Pregnancy Outcomes at a Lower Cost in a Large Cohort of Pregnant Women: The St. Carlos Gestational Diabetes Study. Diabetes Care 2014;37:2442–2450
Authors: René Rodríguez-Gutiérrez, José Gerardo González-González
Journal: Diabetes Care (2015)

We read with interest the article by Duran et al. (1) in which the authors sought to evaluate the outcomes and the cost-effectiveness of the one-step International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria for screening and diagnosis of gestational diabetes mellitus (GDM) compared with the two-step Carpenter-Coustan (CC) criteria. Their …
Sex differences in the management and long-term outcome of acute myocardial infarction. A statewide study. MIDAS Study Group. Myocardial Infarction Data Acquisition System.
Authors: J BKostis, A CWilson, KO'Dowd, PGregory, SChelton, N MCosgrove, AChirala, TCui
Journal: Circulation (1994)

BACKGROUNDWe wished to evaluate whether differences in the rate of invasive cardiac procedures between men and women with acute myocardial infarction are associated with different short- and long-term mortality.METHODS AND RESULTSThe database (Myocardial Infarction Data Acquisition System, MIDAS) included all discharges for the years 1986 and 1987 with the diagnosis of acute myocardial infarction in New Jersey, based on the New Jersey hospital discharge data system (MIDS/UB-82). Accuracy of the data was evaluated by auditing 726 randomly selected charts. The variables examined included age, sex, race, comorbidity (anemia, chronic liver disease, cancer, chronic obstructive pulmonary disease, diabetes, hypertension, prior myocardial infarction), complications (left ventricular dysfunction, arrhythmias, conduction defects), insurance status, performance of cardiac catheterization, percutaneous transluminal coronary angioplasty, or coronary artery bypass graft surgery, and survival up to 3 years. Women were o...
Plasma tumor gene conversions after one cycle abiraterone acetate for metastatic castration-resistant prostate cancer: a biomarker analysis of a multicenter international trial
Authors: A. Jayaram, A. Wingate, D. Wetterskog, G. Wheeler, C.N. Sternberg, R. Jones, A. Berruti, F. Lefresne, M. Lahaye, S. Thomas, M. Gormley, F. Meacham, K. Garg, L.P. Lim, A.S. Merseburger, B. Tombal, D. Ricci, G. Attard
Journal: Annals of Oncology (2021)