tbuckley/cabot-search huggingface dataset:
Abstract P164: Most Non-invasive Diabetes Risk Scores Identify Type 2 Diabetes Due To Insulin Resistance But Not β-cell Failure: The Africans In America Study
Authors: Annemarie Wentzel, Arielle C Patterson, M. Grace Duhuze Karera, Zoe Waldman, Blayne R Schenk, Christopher W DuBose, Anne E Sumner, Margrethe Horlyck-Romanovsky
Journal: Circulation (2022)

Background: Five of the most important Type 2 Diabetes (T2D) prediction scores are: Cambridge, Finnish Diabetes Risk Score (FINDRISC), Rotterdam, Kuwaiti and Omani. These scores are based on the premise that Insulin Resistance (IR) is the primary cause of T2D. Yet, data in Africans suggest β-cell-failure without obesity is the most common cause of T2D. It is unknown whether these scores can identify undiagnosed T2D when the cause is β-cell-failure. Aims: Our aim was to compare in 514 African-born Blacks (age 38±10 (mean±SD); 68% male; BMI 28±5 kg/m 2 ) the ability of Cambridge, FINDRISC, Rotterdam, Kuwait and Omani scores to identify previously undiagnosed T2D due to either IR or β-cell-failure. Methods: Diabetes was diagnosed by OGTT. Insulin resistance was defined by the lowest quartile of the Matsuda index (≤2.97). Beta-cell failure was defined as T2D diagnosis in the absence of IR. Body mass index (BMI), waist circumference (WC) and visceral adipose tissue (VAT) was measured. Area under the Receiver Operator Characteristic curve (AROC) estimated sensitivity, specificity, and criteria for AROC were: 0.70-0.79=acceptable; 0.80-0.89=excellent; &gt;0.90=outstanding. Logistic regression determined odds of T2D at the optimal cut-point for each score. Results: The prevalence of T2D was 7% (38/514). Of the T2D cases, IR occurred in 61% (23/38) and β-cell failure in 39% (15/38). Age did not differ by group, but the IR group had higher BMI (31±5 vs 27±4 kg/m 2 P &lt;0.001) and WC (101±10 vs 91±10 cm P &lt;0.001). This is supported by the higher VAT in the IR group (161±73 vs 106±62 cm 2 P &lt;0.001), an important physiological correlate of insulin resistance. All scores showed acceptable to outstanding predictability for T2D due to IR, ranging from Cambridge at AROC=0.75, to the FINDRISC with AROC=0.92. Only weak to moderate predictability for all scores were shown in β-cell-failure (Cambridge at AROC=0.48 to FINDRISC with AROC=0.63). All models predicted significant odds of T2D due to IR, with FINDRISC≥10 OR=6.8 (95%CI, 2.6, 17.8) P&lt;0 .001; Rotterdam≥7 OR=8.5 (95%CI, 3.1, 23.2) P&lt;0 .001; Cambridge≥23 OR=11.4 (95%CI, 2.6, 50.0) P =0.001) proving most effective. Only the Cambridge score significantly predicted odds of T2D in β-cell-failure (OR=5.7 (95%CI 1.58, 20.54) P =0.001). Conclusions: All 5 diabetes risk scores effectively predicted undiagnosed T2D in Africans when the etiology was IR, but only the Cambridge score predicted T2D when the cause was β-cell failure. The Cambridge risk score rates overweight status, not just obesity status, which might explain why it was successful in predicting T2D in β-cell failure and the others were not. Existing scores which predict T2D might be modified, to effectively assess T2D risk when β-cell failure is the primary cause.
Prostate-Specific Membrane Antigen Radioguided Surgery for Salvage Pelvic Lymph Node Dissection in a Man With Prostate Cancer
Authors: Soheila Erfani, Ramin Sadeghi, Atena Aghaee, HamidReza Ghorbani, Vahid Roshanravan
Journal: Clinical Nuclear Medicine (2021)

Abstract A 75-year-old man with evidence of recurrent prostate cancer on 68 Ga–prostate-specific membrane antigen (PSMA) PET/CT after radical prostatectomy was referred to our department for 99m Tc-PSMA radioguided surgery. Intraoperatively, lymph nodes with high count rates were localized using a handheld gamma probe. High-count specimens were resected from the exact locations as reported by 68 Ga-PSMA PET/CT. The total prostate-specific antigen value decreased 6 weeks after surgery. Our case shows the feasibility of radioguided surgery with 99m Tc-PSMA for salvage lymphadenectomy in prostate cancer.
Abstract 10176: Absolute Perfusion Increase in Remote Myocardium Following Chronic Total Coronary Occlusion Percutaneous Coronary Intervention
Authors: Ruben W de Winter, Stefan P Schumacher, Pepijn A van Diemen, Ruurt A Jukema, Yvemarie B Somsen, Wijnand J Stuijfzand, Roel S Driessen, Michiel J Bom, Henk Everaars, Albert C. C Van Rossum, Peter M van de Ven, Niels J Verouden, Ibrahim Danad, Pieter G Raijmakers, Nap Alexander, Paul Knaapen
Journal: Circulation (2021)

Introduction: Successful revascularization of a chronic total coronary occlusion (CTO) impacts coronary physiology of the remote myocardial territory. This study evaluated the impact of CTO percutaneous coronary intervention (PCI) on absolute perfusion in remote myocardium. Methods: A total of 164 patients underwent serial [ 15 O]H 2 O positron emission tomography (PET) perfusion imaging at baseline and 3 months after successful CTO PCI to evaluate changes in hyperemic myocardial blood flow (hMBF) and coronary flow reserve (CFR) in remote myocardium subtended by non-target collateral donor coronary arteries. Results: Absolute perfusion indices in the CTO and remote myocardium showed a positive linear correlation before (hMBF: r=0.75, p&lt;0.01; CFR: r=0.77, p&lt;0.01) and after (hMBF: r=0.87, p&lt;0.01; CFR: r=0.81, p&lt;0.01) CTO PCI. An increase in absolute myocardial perfusion (hMBF: 2.29±0.67 to 2.48±0.75 mL·min -1 ·g -1 , p&lt;0.01; CFR: 2.48±0.76 to 2.74±0.85, p&lt;0.01) was observed in the remote myocardial territory between baseline and follow-up. Improvements in remote myocardial perfusion were largest in patients with higher increases in hMBF (β 0.55, 95% CI: 0.46-0.64, p&lt;0.01) and CFR (β 0.52, 95% CI: 0.43-0.61, p&lt;0.01) in the CTO territory, independent of clinical, angiographic and procedural characteristics. Furthermore, lower baseline (hMBF: p&lt;0.01; CFR: p&lt;0.01) and higher post-PCI perfusion (hMBF: p&lt;0.01; CFR: p&lt;0.01) in both the remote and CTO territory were associated with larger perfusion increases in remote myocardium. Conclusions: Baseline and post-PCI perfusion indices in remote and CTO myocardium were positively correlated. An overall increase in remote myocardial perfusion was observed following CTO PCI and the absolute perfusion increase in the CTO territory was an independent predictor of remote myocardial perfusion improvement. Successful CTO PCI impacts coronary hemodynamics in the closely interlinked CTO and remote myocardium.
CORONARY FLOW RESERVE AND CARDIOVASCULAR OUTCOMES: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Mihir Kelshiker, Henry Seligman, James P. Howard, Haseeb Rahman, Michael Foley, Alexandra N. Nowbar, Christopher A. Rajkumar, Matthew Shun-Shin, Yousif Ahmad, Sayan Sen, Rasha Al-Lamee, Stephen P. Hoole, Fausto Rigo, Jamil Mayet, Darrel P. Francis, Graham Cole, Paul D. Morris, Ricardo Petraco
Journal: Journal of the American College of Cardiology (2022)
Solitary Chest Wall Tuberculosis Mimicking a Malignancy Demonstrated on FDG PET/CT
Authors: Liu Xiao, Yuhao Li, Lin Li
Journal: Clinical Nuclear Medicine (2022)

Solitary chest wall tuberculosis is rare. Herein, we reported a case of image findings of chest wall tuberculosis in a 44-year-old woman. On FDG PET/CT, it presented as a solitary soft tissue mass with invasion of adjacent rib, diaphragm, and avid FDG uptake with an SUV max of 10.19, mimicking a malignancy. The postoperative pathology supported a diagnosis of tuberculosis infection.
Obstructive Apneas in a Mouse Model of Congenital Central Hypoventilation Syndrome
Authors: Amélia Madani, Gabriel Pitollat, Eléonore Sizun, Laura Cardoit, Maud Ringot, Thomas Bourgeois, Nelina Ramanantsoa, Christophe Delclaux, Stéphane Dauger, Marie-Pia d’Ortho, Muriel Thoby-Brisson, Jorge Gallego, Boris Matrot
Journal: American Journal of Respiratory and Critical Care Medicine (2021)

Rationale: Congenital central hypoventilation syndrome (CCHS) is characterized by life-threatening sleep hypoventilation and is caused by PHOX2B gene mutations, most frequently the PHOX2B27Ala/+ mutation, with patients requiring lifelong ventilatory support. It is unclear whether obstructive apneas are part of the syndrome. Objectives: To determine if Phox2b27Ala/+ mice, which present the main symptoms of CCHS and die within hours after birth, also express obstructive apneas, and to investigate potential underlying mechanisms. Methods: Apneas were classified as central, obstructive, or mixed by using a novel system combining pneumotachography and laser detection of abdominal movement immediately after birth. Several respiratory nuclei involved in airway patency were examined by immunohistochemistry and electrophysiology in brainstem-spinal cord preparations. Measurements and Main Results: The median (interquartile range) of obstructive apnea frequency was 2.3 (1.5-3.3)/min in Phox2b27Ala/+ pups versus 0.6 (0.4-1.0)/min in wild types (P < 0.0001). Obstructive apnea duration was 2.7 seconds (2.3-3.9) in Phox2b27Ala/+ pups versus 1.7 seconds (1.1-1.9) in wild types (P < 0.0001). Central and mixed apneas presented similar significant differences. In Phox2b27Ala/+ preparations, the hypoglossal nucleus had fewer (P < 0.05) and smaller (P < 0.01) neurons, compared with wild-type preparations. Importantly, coordination of phrenic and hypoglossal motor activities was disrupted, as evidenced by the longer and variable delay of hypoglossal activity with respect to phrenic activity onset (P < 0.001). Conclusions: The Phox2b27Ala/+ mutation predisposed pups not only to hypoventilation and central apneas, but also to obstructive and mixed apneas, likely because of hypoglossal dysgenesis. These results thus demand attention toward obstructive events in infants with CCHS.
68Ga-FAPI PET/CT Distinguishes the Reactive Lymph Nodes From Tumor Metastatic Lymph Nodes in a Patient With Nasopharyngeal Carcinoma
Authors: Qihang Shang, Long Zhao, Yizhen Pang, Yifeng Yu, Haojun Chen
Journal: Clinical Nuclear Medicine (2021)

Accurate clinical staging is crucial for managing nasopharyngeal carcinoma (NPC). However, false-positive finding of cervical lymph nodes in 18F-FDG PET/CT and MRI may lead to unnecessary chemotherapy for NPC. In this case, we report a patient with NPC who was incorrectly diagnosed with bilateral cervical lymph node metastases by both 18F-FDG PET/CT and MRI. Subsequent pathology results showed proliferating lymphoid cells with no signs of tumor metastasis. Interestingly, no abnormal 68Ga-FAPI uptake was observed in the nonmetastatic reactive lymph nodes. Therefore, 68Ga-FAPI PET/CT may be useful for assessment of pretreatment lymph node status in NPC.
The global prevalence of and factors associated with Helicobacter pylori infection in children: a systematic review and meta-analysis
Authors: Changzheng Yuan, Davies Adeloye, Tzu Tsun Luk, Liyan Huang, Yusa He, Yunhan Xu, Xinxin Ye, Qian Yi, Peige Song, Igor Rudan
Journal: The Lancet Child & Adolescent Health (2022)
Trends in Late Mortality and Life Expectancy After Autologous Blood or Marrow Transplantation Over Three Decades: A BMTSS Report
Authors: Smita Bhatia, Chen Dai, Wendy Landier, Lindsey Hageman, Jessica Wu, Elizabeth Schlichting, Arianna Siler, Erin Funk, Jessica Hicks, Shawn Lim, Nora Balas, Alysia Bosworth, Hok Sreng Te, Liton Francisco, Ravi Bhatia, Donna Salzman, Frederick D. Goldman, Stephen J. Forman, Daniel J. Weisdorf, F. Lennie Wong, Saro H. Armenian, Mukta Arora
Journal: Journal of Clinical Oncology (2022)

We determined trends in life expectancy and cause-specific late mortality after autologous blood or marrow transplantation (BMT) performed over a 30-year period, using the BMT Survivor Study.We constructed a cohort of 4,702 individuals with hematologic neoplasms who lived ≥ 2 years after autologous BMT performed between 1981 and 2014 at three transplant centers. The end of follow-up was April 19, 2021. The primary exposure variable was autologous BMT performed in four eras: 1981-1999; 2000-2005; 2006-2010; and 2011-2014. Vital status and cause of death were obtained from National Death Index Plus program and Accurinct databases.The median age at BMT was 53 years (range, 0-78 years), 58.7% were male, 67.8% were non-Hispanic White, and 28.3% had undergone transplantation between 2011 and 2014. Autologous BMT recipients experienced a 7-year reduction in life expectancy. The adjusted hazard of 5-year all-cause mortality declined over the four eras (reference: 1981-1999; hazard ratio [HR]2000-2005 = 0.77; 95% CI, 0.62 to 0.94; HR2006-2010 = 0.64; 95% CI, 0.51 to 0.79; HR2011-2014 = 0.56; 95% CI, 0.45 to 0.71; Ptrend < .001), as did years of life lost (5.0 years to 1.6 years). The reduction in all-cause mortality was most pronounced among those transplanted for Hodgkin lymphoma or plasma cell dyscrasias, but was not observed among those transplanted for non-Hodgkin lymphoma or those conditioned with total-body irradiation. We also observed a decline in late deaths because of infection (Ptrend < .0001; primarily for BMTs before 2006) and subsequent neoplasms (Ptrend = .03; confined to decline in therapy-related myeloid neoplasm-related mortality) but not because of cardiovascular or renal disease.Late mortality among autologous BMT recipients has declined over a 30-year period. However, ongoing efforts are needed to mitigate development of infections, subsequent neoplasms, and cardiovascular and renal disease to further reduce late mortality.
The Crohn's disease exclusion diet for induction and maintenance of remission in adults with mild-to-moderate Crohn's disease (CDED-AD): an open-label, pilot, randomised trial
Authors: Henit Yanai, Arie Levine, Ayal Hirsch, Rotem Sigall Boneh, Uri Kopylov, Hagar Banai Eran, Nathaniel A Cohen, Yulia Ron, Idan Goren, Haim Leibovitzh, Joram Wardi, Eran Zittan, Tomer Ziv-Baran, Lee Abramas, Naomi Fliss-Isakov, Barbara Raykhel, Tamar Pfeffer Gik, Iris Dotan, Nitsan Maharshak
Journal: The Lancet. Gastroenterology & hepatology (2021)
Abstract P212: Circulating And Tissue Omega-3 Fatty Acid Biomarkers And Incident Atrial Fibrillation: An Individual Participant-level Pooled Analysis Of Prospective Studies
Authors: Frank Qian, Nathan Tintle, Rozenn Lemaitre, Fumiaki Imamura, Sarah Nomura, Weihua Guan, Eunjung Kim, Jyrki K Virtanen, Christian Bork, Yoichiro Hirakawa, Michelle O'Donoghue, Aleix Sala-Vila, Andres V Ardisson Korat, Qi Sun, Eric B Rimm, Nita G Forouhi, Michael Y Tsai, Julie Pester, Christine M Albert, Toshiharu Ninomiya, Antoni Bayés-Genís, Jason H Wu, Dariush Mozaffarian, William S Harris, David S Siscovick
Journal: Circulation (2022)

Background: Evidence for the role of omega-3 fatty acids in the prevention of atrial fibrillation (AF) remain inconsistent, with some recent RCTs even suggesting possible harm. Whether long-term dietary intake of these fatty acids, as assessed using objective biomarkers, is related to AF is not known. Aims: To prospectively evaluate circulating and tissue levels of eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), docosahexaenoic acid (DHA), and the sum of EPA and DHA (also known as the omega-3 index), with respect to incident AF. Methods: We used data from a global consortium of 13 prospective cohort studies with measurements of EPA, DPA, or DHA in adults (age≥18) identified through March 2021. Participating studies conducted de novo participant-level analyses using a prespecified analytical plan with harmonized definitions for exposures, outcomes, covariates, and subgroups. Associations were pooled using inverse-variance weighted meta-analysis. Results: Among 45,910 participants, a total of 6,229 incident cases of AF were ascertained, with median follow-up ranging from 0.9 to 29.1 years. In the multivariable analysis, per interquintile range (difference between the 90 th and 10 th percentiles for each fatty acid), DPA, DHA, and EPA+DHA ( Figure 1 ) were associated with 11%, 13%, and 9% lower incidence of AF, respectively ( P &lt;0.01 for each). EPA levels were not associated with incident AF. Heterogeneity as measured using I 2 ranged from 0% for DPA to 56.7% for EPA+DHA. Associations were broadly consistent irrespective of baseline cardiovascular risk, global region, age, sex, or lipid fraction. Conclusion: Biomarkers of omega-3 fatty acids including DPA, DHA, and EPA+DHA demonstrated an inverse association with incident AF. In the absence of RCTs examining long-term dietary omega-3 intake and AF risk, our results do not suggest that higher levels of these fatty acids are associated with harm.
Appendiceal Neuroendocrine Tumor Detected by 18F-FDG PET/CT
Authors: Yu Zhang, Huipan Liu, Wei Zhang, Yue Chen
Journal: Clinical Nuclear Medicine (2021)

Abstract Appendiceal neuroendocrine tumor is very rare, and it is difficult to make a definite diagnosis before operation due to absence of specific clinical features. We report the 18 F-FDG PET/CT findings in a patient with an appendiceal neuroendocrine tumor.
Efficacy and safety of weekly paclitaxel with or without ramucirumab as second-line therapy for the treatment of advanced gastric or gastroesophageal junction adenocarcinoma (RAINBOW-Asia): a randomised, multicentre, double-blind, phase 3 trial
Authors: Rui-Hua Xu, Yanqiao Zhang, Hongming Pan, Jifeng Feng, Tao Zhang, Tianshu Liu, Yanru Qin, Shukui Qin, Xianli Yin, Baorui Liu, Yi Ba, Nong Yang, Pei Jye Voon, Suebpong Tanasanvimon, Chan Zhou, Wan Li Zhang, Lin Shen
Journal: The Lancet. Gastroenterology & hepatology (2021)
Can We Predict Rejection Early After Heart Transplantation?
Authors: William F. Fearon, Hannah A. Valantine
Journal: Circulation (2021)

eart transplant recipients are prone to complications, including rejection and cardiac allograft vasculopathy, both of which can occur with minimal or no symptoms.For this reason, transplant recipients often undergo screening invasive evaluation with endomyocardial biopsy and coronary angiography, sometimes including intravascular ultrasound (IVUS).The anatomic demonstration of lymphocyte proliferation and myocyte damage, along with microvascular damage on endomyocardial biopsy, or coronary artery intimal thickening on IVUS diagnose these complications and portend a worse long-term prognosis.
Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8+ T cell responses following COVID-19
Authors: Anna H. E. Roukens, Cilia R. Pothast, Marion König, Wesley Huisman, Tim Dalebout, Tamar Tak, Shohreh Azimi, Yvonne Kruize, Renate S. Hagedoorn, Mihaela Zlei, Frank J. T. Staal, Fenna J. de Bie, Jacques J. M. van Dongen, Sesmu M. Arbous, Jaimie L. H. Zhang, Maaike Verheij, Corine Prins, Anne M. van der Does, Pieter S. Hiemstra, Jutte J. C. de Vries, Jacqueline J. Janse, Meta Roestenberg, Sebenzile K. Myeni, Marjolein Kikkert, Maria Yazdanbakhsh, Mirjam H. M. Heemskerk, Hermelijn H. Smits, Simon P. Jochems, M. S. Arbous, B. M. van den Berg, S. de Bruin-Versteeg, S. Cannegieter, K. Canté, C. M. Cobbaert, A. M. van der Does, J. J. M. van Dongen, J. Eikenboom, M. C. W. Feltkamp, A. Geluk, J. J. Goeman, M. Giera, R. J. Groenland, T. Hankemeier, M. H. M. Heemskerk, P. S. Hiemstra, C. H. Hokke, R. van der Holst, J. J. Janse, S. P. Jochems, S. A. Joosten, M. Kikkert, S. Klaver Flores, L. Lamont, J. Manniën, B. de Mooij, T. H. M. Ottenhoff, K. Pike-Overzet, T. Pongracz, M. R. del Prado, N. Queralt Rosinach, M. Roestenberg, M. Roos, A. H. E. Roukens, Alita J. van der Sluijs-Gelling, H. H. Smits, E. J. Snijder, F. J. T. Staal, L. A. Trouw, R. Tsonaka, A. Verhoeven, L. G. Visser, J. J. C. de Vries, D. J. van Westerloo, J. Wigbers, H. J. van der Wijk, R. C. van Wissen, M. Wuhrer, M. Yazdanbakhsh, M. Zlei, Josine A. Oud, Meryem Baysan, Jeanette Wigbers, Lieke J. van Heurn, Susan B. ter Haar, Alexandra G. L. Toppenberg, Laura Heerdink, Annekee A. van IJlzinga Veenstra, Anna M. Eikenboom, Julia M. Wubbolts, Jonathan Uzorka, Willem Lijfering, Romy Meier, Ingeborg de Jonge, Mark G. J. de Boer, Anske G. van der Bom, Olaf M. Dekkers, Frits Rosendaal
Journal: Nature Immunology (2021)
Malignant Anterior ST-Segment Elevation
Authors: Luca Bergamaschi, Alberto Foà, Carmine Pizzi
Journal: JAMA Internal Medicine (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Imaging Characteristics of Coexisting Metastatic Papillary Thyroid Cancer and Prostate Cancer on 18F-Fluciclovine and 68Ga-PSMA-11 PET/CT
Authors: Yang Lu
Journal: Clinical Nuclear Medicine (2022)

Abstract A 76-year-old man with biopsy-proven metastatic papillary thyroid cancer in a mediastinal nodule status post total thyroidectomy is on surveillance. The patient also had prostate cancer and received prostatectomy and androgen deprivation treatment. An 18 F-fluciclovine PET revealed avid lesions in the mediastinal nodule and a sclerotic focus at L5 with concurrent prostate-specific antigen level of 0.4 ng/mL. The L5 lesion was later biopsied and confirmed as metastasis from prostate cancer. A 68 Ga-PSMA-11 PET 2 months later showed avid radiotracer uptake within L5 metastasis but not the mediastinal nodule. The patient received radiation therapy to the L5 lesion and responded well.
Amyloid Nodules Masquerading as Multifocal Lung Cancer
Authors: Silva Kristo, Tianle Zou, Elizabeth U. Dexter, Saraswati Pokharel
Journal: American Journal of Respiratory and Critical Care Medicine (2021)

"Amyloid Nodules Masquerading as Multifocal Lung Cancer." American Journal of Respiratory and Critical Care Medicine, 205(1), pp. e1–e3
Magnetically Driven Soft Continuum Microrobot for Intravascular Operations in Microscale
Authors: Dan Liu, Xiaoming Liu, Zhuo Chen, Zhaofeng Zuo, Xiaoqing Tang, Qiang Huang, Tatsuo Arai
Journal: Cyborg and Bionic Systems (2022)

Remotely controlled soft continuum robots with active steering capability have broad prospects in medical applications. However, conventional continuum robots have the miniaturization challenge. This paper presents a microscale soft continuum microrobot with steering and locomotion capabilities based on magnetic field actuation. The magnetically driven soft continuum microrobot is made of NdFeB particles and polydimethylsiloxane (PDMS), and it can be as small as 200 μm in diameter. Moreover, a hydrogel layer is covered on the surface of the microrobot, which not only overcomes the adhesion force between the microobjects and the soft tip but also reduces the friction between the microrobot and substrate. The performance test indicates the soft continuum microrobot featured excellent control and steering capabilities. The experimental results demonstrate that the soft continuum microrobot can travel through the microfluidic channel by its own vibration and flexibly steer in a bifurcation environment. Moreover, the micromanipulation of microbeads in the microfluidic channels proves that the proposed microscale soft continuum microrobot has a great potential for intravascular manipulation.