tbuckley/cabot-search huggingface dataset:
Effectiveness of physical activity monitors in adults: systematic review and meta-analysis
Authors: Rasmus Tolstrup Larsen, Vibeke Wagner, Christoffer Bruun Korfitsen, Camilla Keller, Carsten Bogh Juhl, Henning Langberg, Jan Christensen
Journal: BMJ (2022)

Abstract Objective To estimate the effectiveness of physical activity monitor (PAM) based interventions among adults and explore reasons for the heterogeneity. Design Systematic review and meta-analysis. Study selection The electronic databases MEDLINE, Embase, SPORTDiscus, CINAHL, and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched on 4 June 2021. Eligible randomised controlled trials compared interventions in which adults received feedback from PAMs with control interventions in which no feedback was provided. No restrictions on type of outcome measurement, publication date, or language were applied. Data extraction and synthesis Two reviewers independently extracted data and assessed risk of bias. Random effects meta-analyses were used to synthesise the results. The certainty of evidence was rated by the Grading of Recommendations Assessment and Evaluation (GRADE) approach. Main outcome measures The three primary outcomes of interest were physical activity, moderate to vigorous physical activity, and sedentary time. Results 121 randomised controlled trials with 141 study comparisons, including 16 743 participants, were included. The PAM based interventions showed a moderate effect (standardised mean difference 0.42, 95% confidence interval 0.28 to 0.55) on physical activity, equivalent to 1235 daily steps; a small effect (0.23, 0.16 to 0.30) on moderate to vigorous physical activity, equivalent to 48.5 weekly minutes; and a small insignificant effect (−0.12, −0.25 to 0.01) on sedentary time, equal to 9.9 daily minutes. All outcomes favoured the PAM interventions. Conclusions The certainty of evidence was low for the effect of PAM based interventions on physical activity and moderate for moderate to vigorous physical activity and sedentary time. PAM based interventions are safe and effectively increase physical activity and moderate to vigorous physical activity. The effect on physical activity and moderate to vigorous physical activity is well established but might be overestimated owing to publication bias. Study registration PROSPERO CRD42018102719.
Impact of expert center endoscopic assessment of confirmed low grade dysplasia in Barrett’s esophagus diagnosed in community hospitals
Authors: Esther A. Nieuwenhuis, Sanne N. van Munster, Wouter L. Curvers, Bas L. A. M. Weusten, Lorenza Alvarez Herrero, Auke Bogte, Alaa Alkhalaf, B. Ed Schenk, Arjun D. Koch, Manon C. W. Spaander, Thjon J. Tang, Wouter B. Nagengast, Jessie Westerhof, Martin H. M. G. Houben, Jacques J.G.H.M. Bergman, Erik J. Schoon, Roos E. Pouw
Journal: Endoscopy (2022)

Background The optimal management for patients with low grade dysplasia (LGD) in Barrett’s esophagus (BE) is unclear. According to the Dutch national guideline, all patients with LGD with histological confirmation of the diagnosis by an expert pathologist (i. e. “confirmed LGD”), are referred for a dedicated re-staging endoscopy at an expert center. We aimed to assess the diagnostic value of re-staging endoscopy by an expert endoscopist for patients with confirmed LGD. Methods This retrospective cohort study included all patients with flat BE diagnosed in a community hospital who had confirmed LGD and were referred to one of the nine Barrett Expert Centers (BECs) in the Netherlands. The primary outcome was the proportion of patients with prevalent high grade dysplasia (HGD) or cancer during re-staging in a BEC. Results Of the 248 patients with confirmed LGD, re-staging in the BEC revealed HGD or cancer in 23 % (57/248). In 79 % (45/57), HGD or cancer in a newly detected visible lesion was diagnosed. Of the remaining patients, re-staging in the BEC showed a second diagnosis of confirmed LGD in 68 % (168/248), while the remaining 9 % (23/248) had nondysplastic BE. Conclusion One quarter of patients with apparent flat BE with confirmed LGD diagnosed in a community hospital had prevalent HGD or cancer after re-staging at an expert center. This endorses the advice to refer patients with confirmed LGD, including in the absence of visible lesions, to an expert center for re-staging endoscopy.
Immunology and Technology of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccines
Authors: Simone Pecetta, Sven Kratochvil, Yu Kato, Kumaran Vadivelu, Rino Rappuoli
Journal: Pharmacological Reviews (2022)

We have experienced an enormous cohesive effort of the scientific community to understand how the immune system reacts to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and how to elicit protective immunity via vaccination. This effort resulted in the development of vaccines in record time with high levels of safety, efficacy, and real-life effectiveness. However, the rapid diffusion of viral variants that escape protective antibodies prompted new studies to understand SARS-CoV-2 vulnerabilities and strategies to guide follow-up actions to increase, and maintain, the protection offered by vaccines. In this review, we report the main findings on human immunity to SARS-CoV-2 after natural infection and vaccination; we dissect the immunogenicity and efficacy of the different vaccination strategies that resulted in products widely used in the population; and we describe the impact of viral variants on vaccine-elicited immunity, summarizing the main discoveries and challenges to stay ahead of SARS-CoV-2 evolution. SIGNIFICANCE STATEMENT: This study reviewed findings on human immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), analyzed the immunogenicity and efficacy of the various vaccines currently used in large vaccination campaigns or candidates in advanced clinical development, and discussed the challenging task to ensure high protective efficacy against the rapidly evolving SARS-CoV-2 virus. This manuscript was completed prior to the emergence of the Omicron variant and to global vaccine boosting efforts.
Reverse mechanical remodeling by biventricular pacing in congestive heart failure: one-year results from patients in atrial fibrillation in the MUSTIC (MUltisite STimulation in Cardiomyopathy) study
Authors: Cecilia Linde, Christophe Leclercq, Serge Cazeau, Lukas Kappenberger, Richard Sutton, Christophe Bailleul, Jean-Claude Daubert
Journal: Journal of the American College of Cardiology (2002)
Tissue Culture Models of AKI: From Tubule Cells to Human Kidney Organoids
Authors: Julie Bejoy, Eddie S. Qian, Lauren E. Woodard
Journal: Journal of the American Society of Nephrology (2022)

AKI affects approximately 13.3 million people around the world each year, causing CKD and/or mortality. The mammalian kidney cannot generate new nephrons after postnatal renal damage and regenerative therapies for AKI are not available. Human kidney tissue culture systems can complement animal models of AKI and/or address some of their limitations. Donor-derived somatic cells, such as renal tubule epithelial cells or cell lines (RPTEC/hTERT, ciPTEC, HK-2, Nki-2, and CIHP-1), have been used for decades to permit drug toxicity screening and studies into potential AKI mechanisms. However, tubule cell lines do not fully recapitulate tubular epithelial cell properties in situ when grown under classic tissue culture conditions. Improving tissue culture models of AKI would increase our understanding of the mechanisms, leading to new therapeutics. Human pluripotent stem cells (hPSCs) can be differentiated into kidney organoids and various renal cell types. Injury to human kidney organoids results in renal cell-type crosstalk and upregulation of kidney injury biomarkers that are difficult to induce in primary tubule cell cultures. However, current protocols produce kidney organoids that are not mature and contain off-target cell types. Promising bioengineering techniques, such as bioprinting and "kidney-on-a-chip" methods, as applied to kidney nephrotoxicity modeling advantages and limitations are discussed. This review explores the mechanisms and detection of AKI in tissue culture, with an emphasis on bioengineered approaches such as human kidney organoid models.
A Multicenter Assessment of Food Allergy Quality of Life in Adolescents and Caregivers in Relation to Anxiety and Depression during the COVID-19 Pandemic
Authors: Naiya Patel, Layla Samandi, Adam Price, Ashton Rogers, Emily Seminara, Brandi Whitaker, Amika Sood, Diana Munoz-Mendoza, Jing Jin, Paula Roberson, Christopher Parrish, Stacie Jones, Amy Scurlock, J. Andrew Bird
Journal: Journal of Allergy and Clinical Immunology (2022)
Comorbidities, Triggers, Management, and Rate of Resolution of Cholinergic Urticaria in 18 Pediatric Patients
Authors: Madison Le Gallee, Sofianne Gabrielli, Audrey Lovett, Barbara Miedzybrodzki, Connor Prosty, Michelle Le, Elena Netchiporouk, Xun Zhang, Luis Ensina, Moshe Ben-Shoshan
Journal: Journal of Allergy and Clinical Immunology (2022)
The Role of Epinephrine, Antihistamines, and Steroids in the Management of Anaphylaxis: Data from the Cross-Canada Anaphylaxis Registry (C-CARE)
Authors: Luca Delli Colli, Marina Delli Colli, Adnan Al Ali, Sofianne Gabrielli, Ann Clarke, Judy Morris, Jocelyn Gravel, Rod Lim, Edmond Chan, Ran Goldman, Andrew O, Jennifer Gerdts, Derek Chu, Julia Upton, Elana Hochstadter, Adam Bretholz, Christine McCusker, Xun Zhang, Shira Benor, Elinor Simons, Elissa Abrams, Jennifer Protudjer, Moshe Ben Shoshan
Journal: Journal of Allergy and Clinical Immunology (2022)
Effect of proton Pump Inhibitor on Kidney function in a pediatric population with Eosinophilic Esophagitis
Authors: Maria Katerina Alfaro, bridget godwin, Chris Liacouras, Laura Gober, Melanie Ruffner, Jonathan Spergel, Terri Brown-Whitehorn, Amanda Muir, Michele Shuker
Journal: Journal of Allergy and Clinical Immunology (2022)
Adagrasib Data Create Buzz at ESMO
Journal: Cancer Discovery (2021)

In phase I/II KRYSTAL-1 trial, the KRASG12C inhibitor adagrasib demonstrated encouraging clinical activity against metastatic colorectal cancer, both as a monotherapy and when combined with the EGFR inhibitor cetuximab. In patients who received adagrasib alone, the disease control rate was 87% and progression-free survival was 5.6 months. Among patients who received the drug combination, the disease control rate was 100%; data on progression-free survival were immature. The findings, along with data on the KRASG12C inhibitor sotorasib, were presented at the 2021 European Society for Medical Oncology Congress.
Surgical management of ventricular aneurysm
Authors: E. Rolett
Journal: JAMA (1969)

Dr. David Pfaff, Senior Assistant Resident in Medicine, Jewish Hospital of St. Louis, and Assistant in Medicine, Washington University School of Medicine: A 56-year-old white, male, warehouse clerk was hospitalized because of the sudden onset of severe dyspnea two hours before admission. One year ago the patient was hospitalized because of chest pain, after which classic evidence of a predominantly anteroseptal myocardial infarction developed. Warfarin sodium therapy was instituted and he responded well to chlorothiazide drugs. The roentgenogram of the chest immediately prior to discharge showed a probable ventricular aneurysm that was confirmed by fluoroscopic examination. Two months after discharge the patient was hospitalized because of severe precordial pain. Serial electrocardiograms and enzyme determinations showed no changes and the patient was discharged after five days with a diagnosis of coronary failure. ST-segment elevation persisted in leads V<sub>2</sub>and V<sub>3</sub>. Five weeks prior to the present admission the patient
Withdrawn
Authors: Jada Suber, Rishu Guo, A Burks, Michael Kulis, Scott Smith, Onyinye Iweala, Tin Bong, Timothy Lau, Yunji Kim, Maja Nowakowski, Seto Chice, Tech Support, Maria-Anna Vastardi, Helen Durkin
Journal: Journal of Allergy and Clinical Immunology (2022)
"Where Did I See That Paper?"
Authors: J. R. E.
Journal: Annals of Internal Medicine (1967)

Editorials1 August 1967"Where Did I See That Paper?"J. R. E.J. R. E.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-2-459 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMost of our readers will recognize that all-too-common sense of frustration that arises from knowing that somewhere one has seen a piece of now-desirable information but one doesn't quite know just where. The human brain and memory is a biological marvel of nature that out-computes the computer in the realm of the generation and association of ideas but not in the realm of the storage and retrieval of information. Unfortunately, the storage system is usually poorly organized, and the retrieval system is "chancy" at best and, more often than not, totally inadequate. The human memory needs a mechanical aid or...References1. ELKINTON JR: Too much to read (editorial). Ann. Intern. Med. 63: 721, 1965. LinkGoogle Scholar2. JEGHERS H: Medical care, education and research. Philosophy and technics of self-education of the medical student and physician. New Eng. J. Med. 271: 1297, 1964. CrossrefMedlineGoogle Scholar3. BARTLETT LC: Narration: Filed AND found. A personal information storage and retrieval system. JAMA 199: 244, 1967. CrossrefGoogle Scholar4. BUSH V: As we may think. Atlantic Monthly 176: 101, 1945. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPersonal Information Management: An OverviewEstimation of the time for pressure growth in a tank with a cryogenic liquid in zero gravityStudents evaluate medfile, a preprinted medical literature filing systemMicrocomputer-based filing system for emergency medicine literatureA Literature Filing System for the Clinical PharmacistFiling Medical Literature A Textbook-Integrated SystemRICHARD F. GAEKE, B.S., MARY ELLEN B. GAEKE, B.S.RIP OR BIND? A RIPPING RESPONSEH. M. Rawnsley, M.D.AN AUTOMATED LITERATURE RETRIEVAL SYSTEMA System for Filing Medical Literature Based on a Method Developed by Dr. Maxwell M. WintrobeELLIS A. FULLER, M.D., F.A.C.P. 1 August 1967Volume 67, Issue 2Page: 459-460KeywordsBrainComputersInformation storage and retrievalMemory ePublished: 1 December 2008 Issue Published: 1 August 1967 PDF downloadLoading ...
Correction
Journal: BMJ (1958)

BMRNA MEDICAL JOURNAL artery owing to atherosclerosis; here only the treatment of patients suffering from intermittent claudication due to this disease will be discussed.Atherosclerosis is a general disease, and it is important to realize that intermittent claudication is only a local manifes- tation of a general abnormality.Treatment may be medi- cal or surgical.Medical measures include correction of anaemia, reduction of weight, stopping tobacco-smoking, and the use of vasodilator drugs.Surgical measures include sympathectomy and arterial reconstruction operations.In many patients it is a mistake to treat intermittent claudication too actively.For example, a successful arterial reconstruction operation may cure this symptom, only for the patient to be stopped by the worse pain of angina pectoris after he has walked a little further than he did before the operation.However, for those patients with severe symptoms and particularly those who cannot work.active measures are desirable.A bypass type of arterial reconstruction operation is the best method of surgical treatment, and, if successful, results in complete relief.Hyperpyrexia and Survival Q.-What are the highest temperatures in children conmpatible with survival?A.-Children are apt to run higher temperatures than adults, but there is no good reason to believe that extreme hyperpyrexia is tolerated better or worse in children than in adults.In adults, Rogers' studied the mortality of heat stroke and found it, in two series of cases, to be 8.3 % when the body temperature was less than 1070 F. (41.70 C.), 29.2% when the temperature was between 107°and 1090 F. (41.7-42.80C.), and 69.2% when the body temperature exceeded 1090 F. (42.80 C.).Body temperatures of 1120 F. (44.40 C.) with survival have been quoted in the literature.2The same degree of fever is recorded in children.
Changes in oscillometry parameters in reversibility testing as predictors for cough variant asthma
Authors: Yoshihiro Kitahara, Toshihiro Shirai, Hirofumi Watanabe, Shuichi Sugiyama, Kohei Okawa, Kotaro Shiratori, Hiromasa Nakayasu, Toshihiro Masuda, Shingo Takahashi, Yutaro Kishimoto, Shogo Sakurai, Mika Saigusa, Taisuke Akamatsu, Akito Yamamoto, Satoru Morita, Kazuhiro Asada
Journal: Journal of Allergy and Clinical Immunology (2022)
Home care in the 1990s. Council on Scientific Affairs
Journal: JAMA (1990)

Home care is a rapidly growing field that is beginning to attract greater physician interest and participation. Cost-containment pressures have led to reduced institutionalization in hospitals and nursing homes and to more patients, both acutely and chronically ill, being cared for in their own homes. Undergraduate and graduate medical education programs are developing home care curricula, and academic medicine is beginning to develop a research agenda, particularly in the area of clinical outcome measurements. Medical care in the home is highly diversified and innovative. The areas of preventive, diagnostic, therapeutic, rehabilitative, and long-term maintenance care are all well represented as physicians develop new practice patterns in home care.
HAE with normal C1-INH: Treatment and attack frequency based on data from the Canadian 2020 national survey
Authors: Jacquie Badiou, Michelle Cooper, Daphne Dumbrille, Robert Bick, Maggie Dao, Suzanne Kelly, Paul Keith, Gina Lacuesta, Amin Kanani, Chrystyna Kalicinsky, William Yang
Journal: Journal of Allergy and Clinical Immunology (2022)
SARS-CoV-2 Variant Tracking and Mitigation During In-Person Learning at a Midwestern University in the 2020-2021 School Year
Authors: Carolina Avendano, Aaron Lilienfeld, Liz Rulli, Melissa Stephens, Wendy Alvarez Barrios, Joseph Sarro, Michael E. Pfrender, Marie Lynn Miranda
Journal: JAMA Network Open (2022)

The COVID-19 pandemic led many higher education institutions to close campuses during the 2020-2021 academic year. As campuses prepared for a return to in-person education, many institutions were mandating vaccines for students and considering the same for faculty and staff.
International Comments
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An invasive Haemophilus influenzae serotype b infection in an Anglo-Saxon plague victim
Authors: Meriam Guellil, Marcel Keller, Jenna M. Dittmar, Sarah A. Inskip, Craig Cessford, Anu Solnik, Toomas Kivisild, Mait Metspalu, John E. Robb, Christiana L. Scheib
Journal: Genome biology (2022)

The human pathogen Haemophilus influenzae was the main cause of bacterial meningitis in children and a major cause of worldwide infant mortality before the introduction of a vaccine in the 1980s. Although the occurrence of serotype b (Hib), the most virulent type of H. influenzae, has since decreased, reports of infections with other serotypes and non-typeable strains are on the rise. While non-typeable strains have been studied in-depth, very little is known of the pathogen's evolutionary history, and no genomes dating prior to 1940 were available.
Society Proceedings
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Organoids at the PUB: The Porcine Urinary Bladder Serves as a Pancreatic Niche for Advanced Cancer Modeling
Authors: Michael Karl Melzer, Markus Breunig, Frank Arnold, Felix Wezel, Anca Azoitei, Elodie Roger, Jana Krüger, Jessica Merkle, Lena Schütte, Yazid Resheq, Mark Hänle, Viktor Zehe, Friedemann Zengerling, Ninel Azoitei, Lukas Klein, Frederike Penz, Shiv K. Singh, Thomas Seufferlein, Meike Hohwieler, Christian Bolenz, Cagatay Günes, Johann Gout, Alexander Kleger
Journal: Advanced Healthcare Materials (2022)

Despite intensive research and progress in personalized medicine, pancreatic ductal adenocarcinoma remains one of the deadliest cancer entities. Pancreatic duct-like organoids (PDLOs) derived from human pluripotent stem cells (PSCs) or pancreatic cancer patient-derived organoids (PDOs) provide unique tools to study early and late stage dysplasia and to foster personalized medicine. However, such advanced systems are neither rapidly nor easily accessible and require an in vivo niche to study tumor formation and interaction with the stroma. Here, the establishment of the porcine urinary bladder (PUB) is revealed as an advanced organ culture model for shaping an ex vivo pancreatic niche. This model allows pancreatic progenitor cells to enter the ductal and endocrine lineages, while PDLOs further mature into duct-like tissue. Accordingly, the PUB offers an ex vivo platform for earliest pancreatic dysplasia and cancer if PDLOs feature KRASG12D mutations. Finally, it is demonstrated that PDOs-on-PUB i) resemble primary pancreatic cancer, ii) preserve cancer subtypes, iii) enable the study of niche epithelial crosstalk by spiking in pancreatic stellate and immune cells into the grafts, and finally iv) allow drug testing. In summary, the PUB advances the existing pancreatic cancer models by adding feasibility, complexity, and customization at low cost and high flexibility.
Correction: <i>Neoadjuvant nivolumab for patients with resectable HPV-positive and HPV-negative squamous cell carcinomas of the head and neck in the CheckMate 358 trial</i>
Journal: Journal for ImmunoTherapy of Cancer (2021)

Correction: Neoadjuvant nivolumab for patients with resectable HPV-positive and HPV-negative squamous cell carcinomas