tbuckley/cabot-search huggingface dataset:
Abstract P104: Genetic Factors Influence Glycated Hemoglobin, Fasting Glucose, and Fasting Insulin Levels in the Population Architecture Using Genomics and Epidemiology Consortium
Authors: Heather M Highland, Stephanie Bien, Yesha Patel, Abhishek Vishnu, Claudia Schurman, Bridget M Lin, Ran Tao, Danyu Lin, Simin Liu, Lawrence Phillips, Qibin Qi, Jerome I Rotter, Cathy C Laurie, Lucia Hindorf, Stephen Buyske, Tara Matise, Kari E North, Charles Kooperberg, James S Pankow, Ruth J Loos, Christopher Haiman
Journal: Circulation (2017)

Elevated levels of fasting glucose and fasting insulin precede the development type 2 diabetes (T2D). While T2D and cardiovascular disease share common risk factors, dysregulation of glucose metabolism is of particular concern because it can result in end-organ damage including the heart, nerves, kidneys, and eyes. The prevalence of diabetes is higher in American minority populations. Through genome-wide association studies, approximately 60 loci have been identified for fasting glucose, fasting insulin, and glycated hemoglobin. To better understand the genetic basis of glucose dysregulation, the Population Architecture using Genomics and Epidemiology (PAGE) Consortium genotyped 12,801 Hispanic/Latinos, 5,696 African Americans, 1,405 Native Hawaiians, 398 Native Americans, and 1,727 Asians without diabetes using the approximately 1.3 million variants on the Multi-Ethnic Global Array (MEGA), which is enriched for coding variation and ancestral diverse content. Through ancestry-combined single variant association testing with fasting glucose, fasting insulin, and glycated hemoglobin (HbA1c), we identified a novel potential association between decreased HbA1c and the minor A allele of rs11887523 ( p = 4.51x10 -9 , MFSD2B p.A60T, minor allele frequency (MAF) 7% in African Americans, MAF 2% in Hispanics). Other associations with HbA1c included hemoglobin genes, further highlighting the importance of considering variation in hemoglobin and red-blood cell lifespan when using HbA1c as a measure of glucose control. We also replicated several known associations including between fasting glucose and variants near G6PC2, GCKR, MTNR1B, and FOXA2 ; and between fasting insulin and the GRB14/COBLL1 locus. Further analyses including imputing the data out to 1000 Genomes phase3 and gene-based tests of rare variants are underway. These will increase power to detect associations with ancestry-specific rare variants.
The Transcriptomic Landscape of NUP98-Rearranged Pediatric Acute Myeloid Leukemia
Authors: Jenny L. Smith, Eline J.M. Bertrums, Rhonda E. Ries, Fabiana Ostronoff, Amanda R. Leonti, Scott N. Furlan, Bianca F. Goemans, Soheil Meshinchi
Journal: Blood (2020)
Base Excision Repair and Homologous Recombination Pathway Intermediates Drive Genomic Instability and Evolution in Myeloma
Authors: Chengcheng Liao, Srikanth Talluri, Subodh Kumar, Leutz Buon, Jiangning Zhao, Lakshmi B. Potluri, Rao Prabhala, Masood A. Shammas, Nikhil C. Munshi
Journal: Blood (2020)
Tumor Associated Macrophages Express High-Levels of FLT3 Ligand, Which Induces Activation of FLT3 Signaling That Promotes Survival of Neoplastic Cells in B-Cell Acute Lymphoblastic Leukemia
Authors: Yao Guo, Junbin Huang, Dengyang Zhang, Liqin Zhang, Yuming Zhao, Liuting Yu, Zhiguang Chang, Han Zhong Pei, Chun Chen, Hongman Xue, Xiaojun Xu, Zhizhuang Joe Zhao, Yun Chen
Journal: Blood (2020)
Outcomes of Acalabrutinib Failures in Relapsed Mantle Cell Lymphoma
Authors: Preetesh Jain, Shaojun Zhang, Rashmi Kanagal-Shamanna, Lucy Navsaria, Chi Young Ok, Guilin Tang, C. Cameron Yin, Maria Badillo, Wendy Chen, Onyeka Oriabure, Hun Ju Lee, Jason Westin, Loretta J. Nastoupil, Omar Moghrabi, Yuxuan Che, Felipe Samaniego, Sairah Ahmed, Ranjit Nair, Shaoying Li, Francisco Vega, Christopher Flowers, Linghua Wang, Michael Wang
Journal: Blood (2020)
Targeting MYD88-Mutant DLBCL with IRAKIMiDs: A Comparison to IRAK4 Kinase Inhibition and Evaluation of Synergy with Rational Combinations
Authors: Jennifer Kimberly Lue, John S Manavalan, Christine Klaus, Rahul Kanik, Andre M. Grilo, Alice McDonald, Jared Gollob, Duncan Walker, Owen A. O'Connor, Nello Mainolfi
Journal: Blood (2020)
SP0128 Pain – general aspects, review on pain control methods
Authors: J Szechinski
Journal: Annals of the Rheumatic Diseases (2001)

<h3></h3> Pain is pervasive complaint of patients with musculoskeletal disease. There is a tremendous variability in the perception of pain that is modulated by cognitive, emotional and environmental factors. This symptom may result from both and peripheral factors and, in the individual patient, may have individual causes. Because of the interplay of this factors, treatment can entail a variety of pharmacological agents, with drugs modulating central pain as a common component even in patients with structural and inflammatory disease. In older patients and in patients with chronic inflammatory disease, frequent reevaluation may be needed to stage disease and detect intercurrent problems leading to pain. Psychosocial Assesmento of Pain in Patients Having Rheumatic Diseases as well as the Role of Physical Therapy and Physical Modalities In Pain Management is discussed.
High-Grade B-Cell Lymphoma,NOS : Does Prognosis End with the Diagnosis? - a Retrospective Analysis
Authors: Parathan Karunakaran, Gangothri Selvarajan, Jayachandran PK, Nikita Mehra, Shirley Sundersingh, Manikandan Dhanushkodi, Arun Kumar Rajan, Sivasree Kesana, Tenali Gnana Sagar, Krishnarathinam Kannan, Venkatraman Radhakrishnan
Journal: Blood (2020)
Updated Analysis of an Open-Label, Phase 2 Study of Blinatumomab As Second Salvage Therapy in Adults with Relapsed/Refractory Aggressive B-Cell Non-Hodgkin Lymphoma
Authors: Luke Coyle, Nicholas J. Morley, Alessandro Rambaldi, Kylie D. Mason, Gregor Verhoef, Caroline Furness, Rajendra Desai, Noemi Mergen
Journal: Blood (2020)
The Combined Treatment with the FLT3-Inhibitor AC220 and the Complex I Inhibitor Iacs-010759 Synergistically Depletes Wt- and FLT3-Mutated Acute Myeloid Leukemia Cells
Authors: Xiyuan Lu, Alessia Lodi, Lina Han, Joseph R Marszalek, Marina Konopleva, Stefano Tiziani
Journal: Blood (2020)
Predictive Markers of High-Grade or Serious Treatment-Emergent Infections with Daratumumab-Based Regimens in Newly Diagnosed Multiple Myeloma (NDMM)
Authors: Niels W. C. J. van de Donk, Sonja Zweegman, Jesus F. San-Miguel, Meletios A Dimopoulos, Michele Cavo, Kenshi Suzuki, Cyrille Touzeau, Saad Z. Usmani, Aurore Perrot, Huiling Pei, Anupa Kudva, Rian Van Rampelbergh, Jon Ukropec, Kevin Leary, Robin Carson, Ming Qi, Ajai Chari
Journal: Blood (2020)
Abstract PO-111: Identifying epigenetic mechanisms for proliferation and self-renewal of tumor-propagating cells (TPC) in lung cancer
Authors: Eunice Lopez Fuentes, Alejandro Sweet-Cordero
Journal: Cancer Research (2020)

Abstract Lung cancer is a leading cause of death worldwide and lung adenocarcinoma (LUAD) is the most common subtype. LUAD tumors have a functional heterogeneity in regard to tumor-propagating capacity. Cells with an increased capacity to sustain tumor growth are called tumor-propagating cells (TPC or cancer stem cells) and they have been associated with chemoresistance and tumor relapse. A TPC population identified in a mouse model of LUAD (Kras G12D/wt/p53 fl/fl)(KP) sustain growth in serial orthotopic transplantations and are distinguished by expression of Notch receptors. Furthermore, TPCs gene expression signature is associated with a worse prognosis in human cancer. My hypothesis is the TPCs gene expression may be regulated by global chromatin alterations driven by epigenetic regulators. In LUAD, secondary tumors derived from TPC or non-TPC sorted populations regenerated both TPC and non-TPC populations, recapitulating the heterogeneity of the original tumor, suggesting TPC plasticity and supporting an epigenetic regulation. The main goal of my work is to identify and understand epigenetic mechanisms of TPC maintenance in LUAD and determine their relevance for other cancers. TPC and non-TPC populations show dramatic differential protein expression of H3K4me3 and H4K16ac histone modifications associated with transcription activation. To better understand how these histone marks alter the genome of TPCs, I performed ATAC-seq (Assay for Transposase-Accessible Chromatin followed by sequencing) and CARM (CRISPR/Cas9-assisted removal of mitochondrial DNA) to remove mitochondrial DNA prior to sequencing in both TPC and non-TPC populations from primary cells of KP mouse models. I have identified unique open chromatin regions in TPCs which were associated to the closest gene. For TPCs, the main enriched cluster of pathways included Notch signaling pathway and pathways associated with remodeling of the tumor microenvironment. In parallel, I am customizing an epigenetic short hairpin RNA (shRNA) library to screen epigenetic regulators implicated in plasticity and self-renewal ability of TPCs and I will evaluate them whether function through Notch signaling. Citation Format: Eunice Lopez Fuentes, Alejandro Sweet-Cordero. Identifying epigenetic mechanisms for proliferation and self-renewal of tumor-propagating cells (TPC) in lung cancer [abstract]. In: Proceedings of the AACR Virtual Special Conference on Tumor Heterogeneity: From Single Cells to Clinical Impact; 2020 Sep 17-18. Philadelphia (PA): AACR; Cancer Res 2020;80(21 Suppl):Abstract nr PO-111.
The ADAMTS13 Family: In-Patient Trends and Outcomes of Thrombotic Thrombocytopenic Purpura
Authors: Siddharth Bhesania, Deepali Sharath, Stuti Pandya, Dennis Kum, Astha Upadhyaya, Neha Bapat, Pritika Manaktala, Michaela Murphy, Janki Bhesania, Achint Patel, Nivetha Vishnuvardhan, Parag Mehta, Eshan Patel
Journal: Blood (2020)
Longitudinal Assessment of Thrombin Generation in Patients with Hemophilia Receiving Fitusiran Prophylaxis: Phase II Study Results
Authors: Claude Négrier, Margaret V. Ragni, John Pasi, Steven W. Pipe, Gili Kenet, Savita Rangarajan, Salim Kichou, Baisong Mei, Shauna R. Andersson
Journal: Blood (2020)
Oncogenic SETBP1 Mutations Combine with Activating Mutations in CSF3R to Produce a Highly Proliferative, Lethal Leukemia through Aberrant Myc Signaling
Authors: Sarah A Carratt, Theodore P. Braun, Zachary Schonrock, Brittany M. Smith, Daniel J Coleman, Garth Kong, Joseph Estabrook, Adrian Baris, Lauren Maloney, Julia E. Maxson
Journal: Blood (2020)
Perspectives of VA Primary Care Clinicians Toward Electronic Consultation-Related Workload Burden
Authors: Marcie Lee, Chelsea Leonard, Preston Greene, Rachael Kenney, Melanie D. Whittington, Susan Kirsh, P. Michael Ho, George Sayre, Joseph Simonetti
Journal: JAMA Network Open (2020)

Electronic consultation (e-consultation) is increasingly being adopted to expand access to specialty care and reduce health care costs. Little is known about clinicians' perceptions of using e-consultations, which may be associated with program adoption.To identify perceptions of primary care clinicians in the US Veterans Health Administration (VHA) system about e-consultation and workload.A qualitative study using semistructured interviews was conducted from September 2017 through March 2018 in a national sample of VHA primary care clinics in the US. Participants were primary care clinicians who had at least 300 total patient encounters from July 2016 to June 2017, including at least 1 e-consultation request. A convenience sample of participants was recruited using email invitations. Deductive and inductive content analysis were used to identify themes. Data were analyzed from October 2017 to April 2018.Use of e-consultation.Primary care clinician perspectives regarding e-consultation and their workload.A total of 34 primary care clinicians enrolled working across 27 VHA clinical sites were included; 9 (26%) were between ages 40-49 years; 23 (68%) were female. Three themes were identified. First, the process of entering, tracking, and following up on e-consultations added a time burden to primary care clinicians. Second, e-consultation was perceived to shift diagnostic and follow-up responsibilities from specialists to primary care clinicians. Third, e-consultations were thought to improve the timeliness and quality of care provided despite a perceived increase in workload.In this study, participants perceived e-consultation as valuable for patient care but also as an increase in their workload. Further work is warranted to quantify the workload increase on clinician burnout, job satisfaction, and turnover.
Interim Results of the Phase I/II Study of the Ponatinib, Venetoclax and Dexamethasone for Patients with Relapsed or Refractory Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia
Authors: Nicholas J. Short, Marina Konopleva, Elias Jabbour, Tapan M. Kadia, Naval Daver, Robin Cook, Nitin Jain, Farhad Ravandi
Journal: Blood (2020)
THU0042 <i>in vivo</i>pro-inflammatory and anti-inflammatory cytokines levels in patients with rheumatoid arthritis
Authors: KY Fong, KH Yoon, DR Koh, PS Sivalingam, SC Ng
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> Pro-inflammatory and anti-inflammatory cytokines play important roles in the rheumatoid activity process. <h3>Objectives</h3> This study aims to demonstrate the cytokine profiles in rheumatoid arthritis (RA) patients with active and inactive disease process. <h3>Methods</h3> Fifty-three Chinese rheumatoid arthritis patients (8M:45F) and 38 healthy individuals (19M:19F) were enrolled into the study. RA patients were classified as having active disease or in remission according to clinical and serological criteria (morning stiffness, joint pain, joint tenderness, joint swelling, ESR, CRP). At venepuncture, the patients and healthy controls did not have any active infective process. All except 3 patients (in remission) were on SAARDs. Sera obtained in the morning were assayed for the following cytokines: TNFa, IFNg, TGFb, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12 and for rheumatoid factor (RF) by the ELISA method. HLA-DRB1*04 typing was performed using PCR-RFLP. <h3>Results</h3> Forty-two patients had active disease and 11 patients were in remission. Rheumatoid factor was detected in 28 patients and HLA-DR*0405 allele was significantly elevated in RA patients (p &lt; 0.001). TNFa, IL-6 and IL-8 were significantly elevated in RA patients when compared to controls (p &lt; 0.01, p &lt; 0.001, p &lt; 0.018, respectively). Patients with RF positivity were noted to have much higher levels of these 3 pro-inflammatory cytokines. There was however no association with HLA-DR*0405. The anti-inflammatory TGFb was noted to be significantly lower in active patients when compared to inactive patients or controls (p &lt; 0.05). <h3>Conclusion</h3> In conclusion, the serum pro-inflammatory cytokines were significantly elevated in RA patients irrespective of their clinical disease activity while serum TGFb was significantly depressed in active RA patients and normalises when in remission. The exact role that TGFb plays in RA is yet to be fully elucidated.
Leprosy post-exposure prophylaxis with single-dose rifampicin (LPEP): an international feasibility programme
Authors: Jan Hendrik Richardus, Anuj Tiwari, Tanja Barth-Jaeggi, Mohammad A Arif, Nand Lal Banstola, Rabindra Baskota, David Blaney, David J Blok, Marc Bonenberger, Teky Budiawan, Arielle Cavaliero, Zaahira Gani, Helena Greter, Eliane Ignotti, Deusdedit V Kamara, Christa Kasang, Pratap R Manglani, Liesbeth Mieras, Blasdus F Njako, Tiara Pakasi, Basu Dev Pandey, Paul Saunderson, Rajbir Singh, W Cairns S Smith, René Stäheli, Nayani D Suriyarachchi, Aye Tin Maung, Tin Shwe, Jan van Berkel, Wim H van Brakel, Bart Vander Plaetse, Marcos Virmond, Millawage S D Wijesinghe, Ann Aerts, Peter Steinmann
Journal: The Lancet Global Health (2020)

Innovative approaches are required for leprosy control to reduce cases and curb transmission of Mycobacterium leprae. Early case detection, contact screening, and chemoprophylaxis are the most promising tools. We aimed to generate evidence on the feasibility of integrating contact tracing and administration of single-dose rifampicin (SDR) into routine leprosy control activities.The leprosy post-exposure prophylaxis (LPEP) programme was an international, multicentre feasibility study implemented within the leprosy control programmes of Brazil, India, Indonesia, Myanmar, Nepal, Sri Lanka, and Tanzania. LPEP explored the feasibility of combining three key interventions: systematically tracing contacts of individuals newly diagnosed with leprosy; screening the traced contacts for leprosy; and administering SDR to eligible contacts. Outcomes were assessed in terms of number of contacts traced, screened, and SDR administration rates.Between Jan 1, 2015, and Aug 1, 2019, LPEP enrolled 9170 index patients and listed 179 769 contacts, of whom 174 782 (97·2%) were successfully traced and screened. Of those screened, 22 854 (13·1%) were excluded from SDR mainly because of health reasons and age. Among those excluded, 810 were confirmed as new patients (46 per 10 000 contacts screened). Among the eligible screened contacts, 1182 (0·7%) refused prophylactic treatment with SDR. Overall, SDR was administered to 151 928 (86·9%) screened contacts. No serious adverse events were reported.Post-exposure prophylaxis with SDR is safe; can be integrated into different leprosy control programmes with minimal additional efforts once contact tracing has been established; and is generally well accepted by index patients, their contacts, and health-care workers. The programme has also invigorated local leprosy control through the availability of a prophylactic intervention; therefore, we recommend rolling out SDR in all settings where contact tracing and screening have been established.Novartis Foundation.
Daratumumab (DARA) Plus Lenalidomide, Bortezomib, and Dexamethasone (RVd) in Patients with Transplant-Eligible Newly Diagnosed Multiple Myeloma (NDMM): Updated Efficacy and Safety Analysis of the Safety Run-in Population of Griffin
Authors: Peter M. Voorhees, Cesar Rodriguez, Brandi Reeves, Nitya Nathwani, Luciano J. Costa, Yana Lutska, Padma Bobba, Daniela Hoehn, Huiling Pei, Jon Ukropec, Ming Qi, Thomas S. Lin, Paul G. Richardson
Journal: Blood (2020)
UM171-Expanded Cord Blood Transplants Support Robust T-Cell Reconstitution with Low Rates of Severe Infections
Authors: Maude Dumont-Lagacé, Qi Li, Mégane Tanguay, Jalila Chagraoui, Tibila Kientega, Guillaume Cardin, Ann Brasey, Assya Trofimov, Cédric Carli, Imran Ahmad, Nadia M. Bambace, Léa Bernard, Thomas L. Kiss, Jean Roy, Denis-Claude Roy, Sébastien Lemieux, Claude Perreault, Francis Rodier, Simon Frédéric Dufresne, Lambert Busque, Silvy Lachance, Guy Sauvageau, Sandra Cohen, Jean-Sébastien Delisle
Journal: Blood (2020)
Short term results of vaccination with adjuvanted recombinant varicella zoster glycoprotein E during initial BTK inhibitor therapy for CLL or lymphoplasmacytic lymphoma
Authors: Clive S. Zent, Michael T. Brady, Carolyne Delage, Myla Strawderman, Nathan Laniewski, Phuong N. Contant, Preshetha Kanagaiah, Mark Y. Sangster, Paul M. Barr, Charles C. Chu, David J. Topham, Jonathan W. Friedberg
Journal: Leukemia (2020)
Subcutaneous Epcoritamab Induces Complete Responses with an Encouraging Safety Profile across Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma Subtypes, Including Patients with Prior CAR-T Therapy: Updated Dose Escalation Data
Authors: Martin Hutchings, Rogier Mous, Michael Roost Clausen, Peter Johnson, Kim M Linton, Martine E.D. Chamuleau, David John Lewis, Anna Sureda Balari, David Cunningham, Roberto S Oliveri, Dena DeMarco, Brian Elliott, Kuo-mei Chen, Pieternella J. Lugtenburg
Journal: Blood (2020)
Real-World Adherence to National Comprehensive Cancer Network (NCCN) Guidelines Regarding the Usage of PET/CT and Reported Deauville Scores in Advanced Stage Classical Hodgkin Lymphoma: A Community Oncology Practice Perspective
Authors: Christopher A. Yasenchak, Jamyia Clark, Nicholas Liu, April Beeks, Michelle A. Fanale, Nicholas Robert, Kristina Yu-Isenberg
Journal: Blood (2020)
Heart regeneration: beyond new muscle and vessels
Authors: Judy R Sayers, Paul R Riley
Journal: Cardiovascular Research (2020)

The most striking consequence of a heart attack is the loss of billions of heart muscle cells, alongside damage to the associated vasculature. The lost cardiovascular tissue is replaced by scar formation, which is non-functional and results in pathological remodelling of the heart and ultimately heart failure. It is, therefore, unsurprising that the heart regeneration field has centred efforts to generate new muscle and blood vessels through targeting cardiomyocyte proliferation and angiogenesis following injury. However, combined insights from embryological studies and regenerative models, alongside the adoption of -omics technology, highlight the extensive heterogeneity of cell types within the forming or re-forming heart and the significant crosstalk arising from non-muscle and non-vessel cells. In this review, we focus on the roles of fibroblasts, immune, conduction system, and nervous system cell populations during heart development and we consider the latest evidence supporting a function for these diverse lineages in contributing to regeneration following heart injury. We suggest that the emerging picture of neurologically, immunologically, and electrically coupled cell function calls for a wider-ranging combinatorial approach to heart regeneration.
CD20-Modified Exosomes Delivered E260 Inhibits Progression of Diffuse Large B-Cell Lymphoma By Restoring Hippo Activity
Authors: Jiarui Liu, Xiangxiang Zhou, Ya Zhang, Shunfeng Hu, Yang Han, Juan Yang, Yi Zhao, Shuai Ren, Yiqing Cai, Xin Wang
Journal: Blood (2020)
SWOG S1826: A Phase III, Randomized Study of Nivolumab Plus AVD or Brentuximab Vedotin Plus AVD in Patients with Newly Diagnosed Advanced Stage Classical Hodgkin Lymphoma
Authors: Alex F. Herrera, Hongli Li, Sharon M. Castellino, Sarah C. Rutherford, Kelly Davison, Andrew G Evans, Angela Punnett, Louis S. Constine, David C. Hodgson, Susan K Parsons, Anca Prica, Lale Kostakoglu, Margaret A. Shipp, Cara Laubach, Michael L. Leblanc, Michael Crump, Brad S. Kahl, John P. Leonard, Kara M. Kelly, Sonali M. Smith, Jonathan W. Friedberg
Journal: Blood (2020)
Phase 3 Study of Danicopan, an Oral Complement Factor D Inhibitor, As Add-on Therapy to a C5 Inhibitor in Patients with Paroxysmal Nocturnal Hemoglobinuria with Clinically Evident Extravascular Hemolysis
Authors: Austin Kulasekararaj, Antonio Risitano, Jong Wook Lee, Mingjun Huang, Jun-Ichi Nishimura, Alejandra Ramirez-Santiago, Robert Brodsky
Journal: Blood (2020)
The Current Practice of Management of Asymptomatic Central Venous Catheters Associated Venous Thromboembolism in Children: A Result of Saudi Arabian Pediatric Hematology/Oncology Society Survey
Authors: Bader Allahyani, Abdullah Ali, Joshua Feder, Mohammad Alshahrani, Abdulrahman Alsultan, Azzah Alzahrani
Journal: Blood (2020)