tbuckley/cabot-search huggingface dataset:
Kidney Transplant Rejection Clusters and Graft Outcomes: Revisiting Banff in the Era of “Big Data”
Authors: George Vasquez-Rios, Madhav C. Menon
Journal: Journal of the American Society of Nephrology (2021)

The Banff Classification of Allograft Pathology systematically categorizes histologic injury on the basis of acute and chronic renal compartment lesions. The Banff schema was developed by an iterative process involving expert consensus, mainly incorporating data from studies that mapped
Radiofrequency catheter ablation of idiopathic left ventricular tachycardia guided by a Purkinje potential.
Authors: HNakagawa, K JBeckman, J HMcClelland, XWang, MArruda, ISantoro, H AHazlitt, IAbdalla, ASingh, HGossinger
Journal: Circulation (1993)

BACKGROUNDVerapamil-sensitive, idiopathic left ventricular tachycardia (ILVT) with right bundle branch block configuration and left-axis deviation has been suggested to originate from the left posterior fascicle. The purpose of this study was to determine how frequently potentials generated by the Purkinje fiber network (P potential) can be recorded preceding ventricular activation, and the role of the P potential in guiding radiofrequency catheter ablation.METHODS AND RESULTSEight patients (mean age, 26 +/- 10 years) with ILVT (cycle length, 346 +/- 59 milliseconds) were studied. Right and left ventricular endocardial mapping during tachycardia identified earliest ventricular activation at the posteroapical left ventricular septum. In all patients, earliest ventricular activation during tachycardia was preceded by a distinct potential. This potential also preceded ventricular activation during sinus rhythm, consistent with activation of a segment of the left posterior fascicle (P potential). The earliest...
Enteral Stent Placement Versus Eus-Guided Gastroenterostomy for Palliation Of Malignant Gastric Outlet Obstruction: a Comparative Systematic Review and Meta-Analysis
Authors: MB Boghossian, MP Funari, DTH de Moura, TR McCarty, VMT Sagae, YI Chen, PJO Mendieta, FLP Neto, IB Ribeiro, S Cheng, WM Bernardo, EGH de Moura
Journal: Endoscopy (2021)

Aims Malignant gastric outlet obstruction (GOO) is associated with significant morbidity and decreased quality of life. Therefore, effective palliative treatment is critically important. This the first systematic review and meta-analysis to compare enteral stenting (ES) versus endoscopic ultrasound-guided gastroenterostomy (EUS-GE) for palliation of malignant GOO in terms of efficacy and safety.
Plasma renin activity during exercise in the dog.
Authors: M DLifschitz, L DHorwitz
Journal: Circulation Research (1976)

Previous workers have suggested that a rise in plasma renin activity (PRA) may mediate some of the hemodynamic changes associated with exercise. To test this hypothesis in nine dogs chronically instrumented for measurement of aortic pressure (catheter) or cardiac output (ascending aorta electromagnetic flow probe) PRA was measured by radioimmunoassay in blood samples drawn before and during running on a level treadmill at 4-8 miles per hour. Exercise caused increases in heart rate from 96 +/- 5 (SE) to 186 +/- 7 beats/min, cardiac output from 2.8 +/- 0.3 to 6.2 +/- 0.6 liters/min, and mean aortic pressure from 115 +/- 5 to 132 +/- 5 mm Hg (P less than 0.01). Mean PRA was 6.6 +/- 0.7 (SE) ng of angiotensin 1/ml per 3 hours before and 7.6 +/- 1.2 ng Ang I during exercise, values that are not different statistically. Propranolol reduced PRA at rest from 8.6 +/- 1.1 to 5.9 +/- 1.1 ng Ang 1 (P less than 0.05), but there was no significant difference between resting and exercise levels, although the increments ...
Study of the infradiaphragmatic total anomalous pulmonary venous connection with cross-sectional and pulsed Doppler echocardiography.
Authors: M JCooper, D FTeitel, N HSilverman, M AEnderlein
Journal: Circulation (1984)

We studied neonates with the infradiaphragmatic form of total anomalous pulmonary venous drainage by a combination of cross-sectional echocardiography and pulsed Doppler ultrasound. The diagnosis by ultrasound was made prospectively in all six patients. Three large vascular channels could be observed passing through the diaphragm from the subcostal parasagittal plane. The vessels were identified as the descending aorta (to the left), the inferior vena cava (to the right), and the anomalous pulmonary venous channel (in the center). The vessels were insonated in turn, with pulsed Doppler ultrasound, and the characteristic normal flow signals in the aorta and inferior vena cava were obtained. The signal from the anomalous pulmonary vein was a continuous venous signal, the direction of flow being away from the heart. Pulsed Doppler ultrasound allows accurate recognition of the anomalous pulmonary venous channel without the use of contrast echocardiography.
Analysis of Patterns of Co-Occurrence and Mutual Exclusivity of Gene Mutations in Philadelphia-Negative Myeloproliferative (Ph-negative MPNs) and Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPNs)
Authors: Fabio P S Santos, Raquel Ma Paiva, Renato D Puga, Giulliana Ar Goncalves, Tarcila Santos Datoguia, Welbert Oliveira, Bianca Lisboa, Ricardo Helman, Iracema Esteves, Breno Gusmao, Nelson Hamerschlak, Paulo Vidal Campregher
Journal: Blood (2017)
Swimming causes myosin adaptations in the rat cardiac isograft.
Authors: S VAdvani, DGeenen, AMalhotra, S MFactor, JScheuer
Journal: Circulation Research (1990)

To investigate the contributions of humoral and hemodynamic factors to cardiac adaptations associated with chronic exercise, female Fischer 344 rats were subjected to chronic swimming, infrarenal cardiac transplantation, or both. Swimming resulted in hypertrophy (11-12%) of the in situ hearts in both the unoperated and operated animals compared with the matched sedentary controls. The cardiac isograft exhibited atrophy (32-35%), which was not attenuated by swimming. The cardiac isograft was also associated with a decrease in the percent of V1 myosin isoenzyme, which was attenuated by swimming (45 +/- 5% versus 66 +/- 6%). Swimming also increased the percent of this isomyosin in the in situ hearts of operated rats. These data suggest that hemodynamic load and/or neural innervation are necessary for hypertrophy associated with chronic conditioning by swimming, whereas myosin isoenzyme control is significantly mediated by humoral factors.
Development and determinants of dynamic obstruction to left ventricular outflow in young patients with hypertrophic cardiomyopathy.
Authors: J APanza, T JMaris, B JMaron
Journal: Circulation (1992)

BACKGROUNDTo study the development of dynamic subaortic obstruction in young patients with hypertrophic cardiomyopathy (HCM), serial echocardiograms were retrospectively analyzed in a group of 26 consecutive children with this disease who showed no evidence of dynamic outflow obstruction at their initial evaluation (age, 11 +/- 3 years).METHODS AND RESULTSAfter a follow-up of 3-12 years (mean, 7 +/- 3 years), seven of the 26 patients (27%) developed echocardiographic evidence of subaortic obstruction, i.e., marked systolic anterior motion (SAM) of the mitral valve with mitral-septal apposition and increased left ventricular outflow tract systolic velocities (3.8 +/- 0.3 m/sec; range, 3.1-4.5). Patients who developed SAM had smaller transverse dimension of the left ventricular outflow tract and more anteriorly displaced mitral valve when initially evaluated than did patients without development of SAM (outflow tract dimension, 19.1 +/- 4 versus 24.6 +/- 4 mm; mitral valve position index, 1.07 +/- 0.2 versu...
Weekend And Evening Planned Colonoscopy Activity - A Safe And Effective Way To Meet Demands
Authors: A Afify, O Abo-Elazm, M Thoufeeq
Journal: Endoscopy (2021)

Aims Our aim was to investigate the quality of colonoscopies carried out during evening and Saturday lists in our unit and compare against JAG standards of quality for colonoscopies. Other factors that may affect the KPIs such as the endoscopists experience and bowel preparation were also analysed.
Long-term serial angiographic studies after coronary artery bypass surgery.
Authors: D FGuthaner, E WRobert, E LAlderman, LWexler
Journal: Circulation (1979)

Twenty-six patients underwent repeat coronary angiography 5--8 years after saphenous vein coronary artery bypass surgery (SVCABG). These patients were selected from the first cohort of 117 patient who had SVCABG because they had obtained essentially complete relief of angina, and because all grafts were patent at initial angiography 11.2 months (mean) after surgery. Of the 39 grafts (1.5 grafts per patient) patent at 1 year, 34 (87.2%) were patent at reexamination 76 months (mean) (range 65--103 months) after SVCABG. Graft occlusion could not be predicted by the early angiographic appearance of the graft itself or its proximal or distal anastomosis. In some cases, narrowing or irregularity consistent with intimal hyperplasia appeared to progress, while in others it developed at late follow-up. Progressive narrowing occurred in 96% (22 of 23 grafted vessels) of the native coronary arteries proximal to the graft anastomosis. Progresssion to a stenosis greater than 75% or total occlusion was seen distal to t...
Improved selection of patients for programmed ventricular stimulation by frequency analysis of signal-averaged electrocardiograms.
Authors: B DLindsay, H DAmbos, K BSchechtman, M ECain
Journal: Circulation (1986)

Improved selection of patients with suspected sustained ventricular tachycardia (VT) for programmed ventricular stimulation is needed. To determine if frequency analysis detects patients in whom sustained VT might be induced, we first obtained fast-Fourier transforms (FFT) of signal-averaged electrocardiograms (ECGs) from 20 patients with spontaneous sustained VT (group 1) and compared them with the results of programmed ventricular stimulation with single and double extrastimuli during two cycle lengths and burst pacing from two right ventricular sites. The FFT data were expressed as an area ratio that quantified the relative contributions of 20 to 50 Hz frequencies in the terminal QRS and ST segment. A logistic regression with inducibility as the dependent variable was used to help define area ratio values greater than 20 as abnormal. Sustained monomorphic VT was induced in 18 patients, each with an area ratio value greater than 20. Sustained VT was not induced in two patients, each with an area ratio v...
Resistance to blood flow in microvessels in vivo.
Authors: A RPries, T WSecomb, TGessner, M BSperandio, J FGross, PGaehtgens
Journal: Circulation Research (1994)

Resistance to blood flow through peripheral vascular beds strongly influences cardiovascular function and transport to tissue. For a given vascular architecture, flow resistance is determined by the rheological behavior of blood flowing through microvessels. A new approach for calculating the contribution of blood rheology to microvascular flow resistance is presented. Morphology (diameter and length), flow velocity, hematocrit, and topological position were determined for all vessel segments (up to 913) of terminal microcirculatory networks in the rat mesentery by intravital microscopy. Flow velocity and hematocrit were also predicted from mathematical flow simulations, in which the assumed dependence of flow resistance on diameter, hematocrit, and shear rate was optimized to minimize the deviation between measured and predicted values. For microvessels with diameters below approximately 40 microns, the resulting flow resistances are markedly higher and show a stronger dependence on hematocrit than previ...
Endoscopic Expert Revision of Previous Histological Confirmed Flat Low-Grade Dysplasia In Barrett’s Esophagus
Authors: EA Nieuwenhuis, SN van Munster, BLAM Weusten, L Alvarez Herrero, A Bogte, A Alkhalaf, BE Schenk, E Schoon, WL Curvers, AD Koch, MCW Spaander, T Tang, WB Nagengast, J Westerhof, MHMG Houben, JJGHM Bergman, RE Pouw
Journal: Endoscopy (2021)

Aims The strongest histologic predictor for progression to high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC) in Barrett’s esophagus (BE) is expert confirmed diagnosis of low-grade dysplasia (LGD). Therefore, Dutch guidelines advise to refer patients with confirmed LGD to a Barrett’s Expert Center (BEC). Aim was to assess if a community finding of confirmed LGD in BE without visible lesions (VL), is an indicator for higher grades of dysplasia.
Alterations of heart rate and of heart rate variability after radiofrequency catheter ablation of supraventricular tachycardia. Delineation of parasympathetic pathways in the human heart.
Authors: D ZKocovic, THarada, J BShea, DSoroff, P LFriedman
Journal: Circulation (1993)

BACKGROUNDPersistent inappropriate sinus tachycardia has been reported as a complication after radiofrequency (RF) ablation of the fast atrioventricular (AV) nodal pathway. The purpose of this study was to evaluate the prevalence of this complication and its mechanism using heart rate variability analysis.METHODS AND RESULTSTime and frequency domain analysis of heart rate was performed in the electrophysiology laboratory immediately before and immediately after RF ablation in 64 patients with supraventricular tachycardia. Ablation targets in these 64 patients included the fast AV nodal pathway (n = 3), the slow AV nodal pathway (n = 14), a posteroseptal accessory pathway (n = 23), and a left lateral accessory pathway (n = 24). A control group of 21 patients undergoing diagnostic study but not ablation underwent identical analysis immediately before and at the conclusion of their procedure. Patients undergoing ablation also had time and frequency domain analysis performed on ambulatory 24-hour Holter tapes...
Instantaneous hyperemic flow-versus-pressure slope index. Microsphere validation of an alternative to measures of coronary reserve.
Authors: G BMancini, R MCleary, S FDeBoe, N BMoore, K PGallagher
Journal: Circulation (1991)

BACKGROUNDThe instantaneous hyperemic flow-versus-pressure (i-HFVP) slope index is a new method of assessing maximal coronary conductance and can be used as an alternative to conventional measures of coronary reserve. The i-HFVP slope index is determined by measuring the slope of the linear diastolic segment of the relation between instantaneous aortic pressure and hyperemic coronary flow.METHODS AND RESULTSTo validate the i-HFVP slope index as a measure of maximal coronary conductance, we compared this method with a microsphere-derived measurement of maximal coronary conductance (m-HFVP slope index) by determining the slope of the least-squares regression line of the data points for coronary flow during maximal hyperemia and four or five steady-state alterations of aortic pressure in 43 dogs (open-chest, anesthetized preparations) with or without coronary stenoses. The i-HFVP slope index demonstrated no dependence on heart rate, left ventricular end-diastolic pressure, or mean aortic pressure and was hig...
Protamine inhibits capillary formation in growing rat hearts.
Authors: KRakusan, ZTurek
Journal: Circulation Research (1985)

Various indices of capillary supply to the rat heart were studied in neonatal rats injected for 2 or 4 weeks with protamine sulfate in saline (subcutaneously, 60 mg/kg body weight, 2 times/day). Cardiac capillarization was evaluated not only by traditional indices for the capillary supply, such as mean capillary density and myocyte-to-capillary ratio, but also by a more advanced morphometric method of capillary domains. This method allows the estimation of both the average radius of the Krogh tissue cylinder and its variability, which reflects the heterogeneity of capillary spacing found to be an independent morphological determinant of oxygen diffusion in the tissue. The results were evaluated with respect to regional differences (subendocardial vs. middle section), age differences, and the effect of protamine. No regional differences in capillary supply were found in this experimental situation. Hearts from older rats had significantly decreased capillary supply, expressed as lower capillary density, la...
Prophylactic digitalization for coronary artery bypass surgery.
Authors: L WJohnson, R ADickstein, C TFruehan, PKane, J LPotts, HSmulyan, W RWebb, R HEich
Journal: Circulation (1976)

One hundred and twenty patients undergoing aortocoronary bypass procedures were randomly placed into control and digitalized groups. All were initially in normal sinus rhythm and without evidence of congestive heart failure. Supraventricular arrhythmias occurred in 17 of 66 controls and in only three of 54 digitalized patients (P less than 0.01). There was no evidence of digitals toxicity. Based on this evidence we recommend prophylactic digitalization for patients having aortocoronary bypass operations.
Numbers needed to treat to prevent tuberculosis
Authors: Alberto Matteelli, Knut Lönnroth, Haileyesus Getahun, Dennis Falzon, Giovanni Battista Migliori, Mario Raviglione
Journal: European Respiratory Journal (2015)

We thank Martina Sester and colleagues for their careful reading of our paper [1] and for their support to the prospect of tuberculosis (TB) elimination in low-incidence countries in a foreseeable future. While we respect the views of the authors that the targets may appear too ambitious, we believe that, if the scientific community stay focussed on innovative approaches that can translate into scalable and effective interventions, we could reap the benefits of such interventions within the space of the next two decades [2]. Figure 1 shows the trend in TB incidence into the future, should current efforts to control TB – including the treatment of latent Mycobacterium tuberculosis infection (LTBI) – be intensified and boosted by new techniques and approaches. Continued research is crucial to reach elimination targets, which will be unattainable unless new tools are developed <http://ow.ly/TFYNi> This article is one of a selection of articles published as ERJ Open papers, as part of an initiative agreed between the European Respiratory Society and the World Health Organization.
Increased plasma catecholamine concentrations and vas deferens norepinephrine biosynthesis in men with elevated blood pressure.
Authors: VDeQuattro, YMiura, ALurvey, MCosgrove, RMendez
Journal: Circulation Research (1975)

Systemic biochemical indexes of sympathetic nerve functionplasma catecholamine concentrations and serum dopamine-beta-hydroxylase activitywere correlated with regional indexesnorepinephrine concentration activities of norepinephrine biosynthetic enzymes in the vas deferensānd with blood pressures and pulse rates of 57 men at the time of vasectomy. Mean plasma catecholamine content was increased 66% and 60% in men with elevated systolic and elevated systolic and diastolic blood pressures, respectively. The norepinephrine concentration, tyrosine hydroxylase activity, and dopa decarboxylase activity in the vas deferens were increased in 12%, 26%, and 17% of the men with elevated blood pressure, respectively. Tyrosine hydroxylase and dopa decarboxylase in the men with elevated systolic blood pressure were increased 41% and 68%, respectively, compared with values in the men with normal blood pressure (P less than 0.05 and P less than 0.02). Individual plasma catecholamine content was related directly to both s...
The “War on Drugs” Affects Children Too: Racial Inequities in Pediatric Populations
Authors: Emily W. Kemper, Emily Davis, Anthony L. Bui, Austin DeChalus, Melissa Martos, Jessica E. McDade, Tracy L. Seimears, Aleksandra E. Olszewski
Journal: The American Journal of Bioethics (2021)

Earp, Lewis, and Hart (2021) write about the racism entrenched in policies criminalizing drug use and possession and describe the disparate impact that these policies have on certain racialized com...
Abstract 10471: Mitochondrial Ca2+ Flux Contributes to Arrhythmia During Acute Ischemia
Authors: An Xie, Hong Liu, Feng Feng, Gyeoung-Jin Kang, Bum-Rak Choi, Tae Yun Kim, Samuel C Dudley
Journal: Circulation (2019)

Introduction: During acute myocardial infarction (AMI), spontaneous and induced lethal ventricular arrhythmias such as ventricular tachycardia and fibrillation are common. Acute ischemia affects mi...
Acidic and basic fibroblast growth factors in adult rat heart myocytes. Localization, regulation in culture, and effects on DNA synthesis.
Authors: ESpeir, VTanner, A MGonzalez, JFarris, ABaird, WCasscells
Journal: Circulation Research (1992)

Basic fibroblast growth factor (bFGF) and acidic fibroblast growth factor (aFGF) are involved in the induction of embryonic mesoderm, angiogenesis, neuronal differentiation, and proliferation and survival of many cell types. In cardiac myocytes their roles are not well understood. Effects of fibroblast growth factors on reexpression of fetal actin genes have been reported. In freshly isolated adult rat cardiac myocytes, bFGF mRNA was not detectable by in situ hybridization, although the cells contained significant amounts of bFGF and aFGF as quantified by radioimmunoassays, mitogen assays with immunoneutralization, and Western blotting. After culturing, bFGF mRNA was detected (aFGF mRNA was not studied), and the cells contained 2.5-fold more bFGF and 60% more aFGF than freshly isolated cells. The FGFs were not found in conditioned medium. They were localized, especially in cultured cells, to the nucleus. Cultured myocytes bound fourfold more 125I-FGF than freshly isolated cells and expressed the fibroblas...
Outcomes and Prognostic Factors in Angioimmunoblastic T cell Lymphoma: Final Report from the International TCell Project
Authors: Ranjana Advani, Tetiana Skrypets, Monica Civallero, Michael A Spinner, Martina Manni, Wonseog Kim, Andrei Shustov, Steven M. Horwitz, Felicitas Hitz, Maria Elena Cabrera, Ivan Dlouhy, Jose Vassallo, Stefano A Pileri, Giorgio GA Inghirami, Silvia Montoto, Umberto Vitolo, John Radford, Julie Vose, Massimo Federico
Journal: Blood (2021)
Differences in Thallium-201 uptake in reperfused and nonreperfused myocardial infarction.
Authors: J AMelin, L CBecker, B HBulkley
Journal: Circulation Research (1983)

The respective importance of flow and cellular viability in determining initial myocardial thallium uptake was studied in reperfused and nonreperfused experimental myocardial infarction. Open-chest dogs were subjected to permanent coronary artery occlusion of 70-minute (n = 3) or 5-hour duration (n = 5), or to a 3-hour temporary occlusion followed by reflow (n = 14). Thallium uptake 10 minutes after intravenous injection was compared directly with radioactive microspheres in myocardial samples from excised hearts. Triphenyl tetrazolium chloride staining was used to differentiate necrotic and viable samples with confirmation by electron microscopy. In nonreperfused infarcts, thallium uptake occurred despite necrosis, and a close correlation was found between thallium uptake and regional myocardial blood flow. In reperfused infarcts, thallium uptake again occurred, but was reduced relative to flow in necrotic myocardium and, to a lesser extent, in reperfused viable areas. However, because of the high levels...