tbuckley/cabot-search huggingface dataset:
Assessment of Diagnostic Strategy for Mucous Membrane Pemphigoid
Authors: Hanan Rashid, Joost M. Meijer, Gilles F. H. Diercks, Nini E. Sieben, Maria C. Bolling, Hendri H. Pas, Barbara Horvath
Journal: JAMA Dermatology (2021)

An accurate diagnosis of mucous membrane pemphigoid (MMP) is essential to reduce diagnostic and therapeutic delay.To assess the diagnostic accuracy of direct immunofluorescence microscopy on mucosal biopsy specimens and immunoserology in a large cohort of patients with suspected MMP.This retrospective cohort study was carried out in a single tertiary care center for blistering diseases between January 2002 and March 2019. Eligible participants were patients with suspected MMP and paired data on at least a mucosal biopsy specimen for direct immunofluorescence microscopy (DIF) and indirect immunofluorescence microscopy (IIF) on a human salt-split skin substrate (SSS). In addition, an optional DIF test on a skin biopsy specimen and one or more performed routine immunoserologic tests were analyzed. Data analysis was conducted from April 2019, to June 2020.Diagnostic accuracy of DIF, IIF SSS, and immunoblot for BP180 and BP230.Of the 787 participants, 121 (15.4%) received the diagnosis of MMP (50 men [41.3%], 71 women [58.7%]; mean [SD] age at diagnosis, 60.1 [17.7] years). Sixty-seven of the patients with MMP (55.4%) had monosite involvement, of which oral site was the most frequently affected (51 [42.1%]). No significant difference was found between the sensitivity of DIF on a perilesional buccal biopsy and a normal buccal biopsy (89.3% vs 76.7%). Three patients with solitary ocular involvement showed a positive DIF of only the oral mucosa. In 6 patients with a negative mucosal DIF, a skin biopsy confirmed diagnosis of MMP. Overall, IIF SSS was less sensitive (44.6%), but highly specific (98.9%). The sensitivity of immunoblot (66.1%) was higher compared to SSS, but with lower specificity (91.3%).This comparative diagnostic accuracy study of a cohort of 787 patients found a high sensitivity of a mucosal DIF biopsy for diagnosis of MMP, and lower sensitivity of serologic analysis. A biopsy can be taken from either perilesional or normal buccal mucosa. An additional DIF biopsy of another mucosal site or of affected or unaffected skin may increase the diagnostic yield and is recommended in patients with negative DIF results and high clinical suspicion.
SERUM CHOLESTEROL EARLIER VERSUS LATER IN LIFE AS A PREDICTOR OF CAD AND CARDIOVASCULAR MORTALITY
Authors: Andreas Leiherer, Hanno Ulmer, Axel Muendlein, Christoph H. Saely, Alexander Vonbank, Barbara Larcher, Arthur Mader, Maximilian Maechler, Lukas Sprenger, Beatrix Mutschlechner, Peter Fraunberger, Bernhard Foeger, Wolfgang Brozek, Gabriele Nagel, Emanuel Zitt, Heinz Drexel, Hans Concin
Journal: Journal of the American College of Cardiology (2021)
Abstract 15529: Multimorbidity Clusters in Patients Presenting to the Emergency Department With Potential Acute Coronary Syndrome
Authors: Katherine Breen, Lorna Finnegan, Karen M Vuckovic, Anne M Fink, Wayne D Rosamond, Holli A Devon
Journal: Circulation (2020)

Introduction: The increasing prevalence of multimorbidity (&gt; 2 chronic conditions) is a challenge for healthcare providers and systems. Multimorbidity complicates treatment and increases the risk of adverse outcomes. Objectives: To identify multimorbidity classes (clusters of &gt; 2 specific chronic conditions) in a secondary analysis of a multi-site study about symptoms in patients presenting to the emergency department (ED) for potential acute coronary syndrome (ACS). Hypothesis: Specific multimorbidity classes can predict an ACS diagnosis. Methods: Chronic conditions were measured (Charlson Comorbidity Index and ACS Patient Information Questionnaire) in patients who underwent a cardiac evaluation in the ED. Latent class analysis was used to identify multimorbidity classes, and logistic regression determined whether multimorbidity classes were predictive of being ruled-in versus ruled-out for ACS. Results: The sample ( n = 935) was 38% female, with a mean age of 59 years. Four multimorbidity classes were identified and labeled: High multimorbidity (Class 1, hyperlipidemia, hypertension [HTN], obesity, diabetes, and respiratory disorders); Low multimorbidity (Class 2, obesity); Cardiovascular multimorbidity (Class 3, HTN, hyperlipidemia, and coronary heart disease); and Cardio-oncology multimorbidity (Class 4, HTN, hyperlipidemia, and cancer). Patients in Classes 3 and 4 had a 2.8-fold and 1.7-fold increased risk of ruling-in for ACS compared to those in Class 2 who were half as likely to rule-in for ACS (OR 0.45 95% CI 0.33 to 0.61 p=0.001). Class membership differed by sex, age, and family history. Females were more likely to be in Class 1 (44.2%), younger patients in Class 2 (mean age 43.4 ± 9.8 years), older patients in class 4 (mean age 80.0 ± 6.3 years), and those with a family history of sudden cardiac death (&lt; age 55) in Class 3 (58.3%). Conclusion: Multimorbidity classes differed according to demographic and clinical variables. Membership in Classes 3 and 4 were predictive of an ACS diagnosis. Clustering patients by multimorbidity class may inform risk-stratification during evaluation for ACS.
THE NEW MYOKINE MYONECTIN IS SIGNIFICANTLY ASSOCIATED WITH TYPE 2 DIABETES IN PATIENTS WITH PERIPHERAL ARTERY DISEASE
Authors: Axel Muendlein, Kathrin Geiger, Andreas Leiherer, Christina Zach, Barbara Larcher, Arthur Mader, Maximilian Maechler, Lukas Sprenger, Beatrix Mutschlechner, Alexander Vonbank, Christoph H. Saely, Christine Heinzle, Peter Fraunberger, Heinz Drexel
Journal: Journal of the American College of Cardiology (2021)
THE CLINICAL ASSOCIATION BETWEEN CARBON MONOXIDE POISONING AND MYOCARDIAL INJURY
Authors: Demian Jideofor Omeh, Gary Tackling, Rohun Gupta, Tiffany Sahadeo, Viliane Vilcant, Tashina Dussie, Ofek Hai, Roman Zeltser, Amgad Makaryus
Journal: Journal of the American College of Cardiology (2021)
Covid-19非洲的死亡：未来系统的后期监测研究
Authors: 劳伦斯蒙旺达达, 克里斯托弗J. Gill., 威廉麦利德, 杰弗里 Kwenda, rachel pimiak., Zachariah. Mupila., Rotem Lapidot., Francis Mupeta, Leah Form., Luunga Ziko., Lauren Etter., 唐纳德蒂
Journal: BMJ (2021)

Abstract  Objective  直接衡量2019年冠状病毒疾病（Covid-19）在城市人口中的致命影响。  Design  潜在系统后期监测研究。  Setting  赞比亚最大的大专院护理转诊医院。  Participants  在赞比亚卢萨卡的大学教学医院Morgue的已故人士在死亡48小时内注册。  Main outcome measure  通过逆转录酶定量聚合酶链反应（PCR）对重度急性呼吸综合征冠状病毒2（SARS-COV-2）进行测试后鼻咽拭子。 Covis-19状态，地点，年龄，性别和潜在风险因素分层死亡。  Results  372名参与者在6月和9月20日期间注册; PCR结果可用于364（97.8％）。根据建议的循环阈值，在58/364（15.9％）中检测到SARS-COV-2  Conclusions  与期望相反，与Covid-19的死亡在卢萨卡常见。大多数人发生在社区，其中缺乏测试能力。然而，尽管呈现了Covid-19的典型症状，但仍有很少的人死于设施。因此，未报告Covid-19的病例，因为测试很少没有，因为Covid-19很少。如果这些数据是宽大的，则Covid-19在非洲的影响已经大大低估了。
MYOCARDIAL PROTECTION STRATEGIES DURING TRANSCATHETER PDA CLOSURE IN ELBW INFANTS TO PREVENT POST-LIGATION SYNDROME
Authors: Ranjit Philip, Jonathan Spagnoli, Genevieve DuPuis, Evan Harvey, Nathan Stecchi, Neil Tailor, Benjamin Waller, Shyam Sathanandam
Journal: Journal of the American College of Cardiology (2021)
MONITORING NT-PRO-BNP LEVELS AND STROKE VOLUME CHANGES OVER TIME AS COMBINATORY PARAMETERS TO PREDICT WORSENING HEART FAILURE
Authors: Monica Barki, Maurizio Losito, Michela Maria Caracciolo, Francesco Bandera, Marina Rovida, Eleonora Alfonzetti, Margherita Carrozzo, Marco Guazzi
Journal: Journal of the American College of Cardiology (2021)
HIGH SENSITIVITY TROPONIN T AND NT-PROBNP IN PATIENTS RECEIVING CHIMERIC ANTIGEN RECEPTOR (CAR) T-CELL THERAPY
Authors: Jiun-Ruey Hu, Ameet Patel, Yan-Ru Su, Kimberly B. Dahlman, Kelsey Tomasek, Shi Huang, Yueli Zhang, Richard T. O’Neil, Jamye F. O’Neal, Douglas B. Johnson, Joe-Elie Salem, Olalekan Oluwole, Javid Moslehi
Journal: Journal of the American College of Cardiology (2021)
ONE YEAR SURVIVAL POST TAVR IN PATIENTS WITH NORMAL-FLOW-LOW-GRADIENT VS. PARADOXICAL LOW-FLOW-LOW GRADIENT AORTIC VALVE STENOSIS
Authors: Mohamad Hemu, Caleb Chiang, Jaafar Alward, Konstantinos Voudris, Hussam Suradi
Journal: Journal of the American College of Cardiology (2021)
NONINVASIVE 12-LEAD ECG COMPUTATIONAL SIMULATION MAPPING TO GUIDE STEREOTACTIC ABLATION FOR A CASE OF POLYMORPHIC VENTRICULAR TACHYCARDIA
Authors: Kevin Sung, Gordon Ho, Christopher Villongco, Andrea Sandry, Sandhya Sihra, Jamie Marsal, Todd Atwood, AJ Mundt, David Krummen
Journal: Journal of the American College of Cardiology (2021)
Emergency Department Visits and Hospitalizations for Selected Nonfatal Injuries Among Adults Aged ≥65 Years — United States, 2018
Authors: Briana Moreland, Robin Lee
Journal: MMWR Morbidity and Mortality Weekly Report (2021)

Approximately 60,000 older adults (aged ≥65 years) die from unintentional injuries each year; in 2019 these included 34,000 fall deaths, 8,000 traffic-related motor vehicle crash deaths, and 3,000 drug poisoning deaths (1). In addition, >9,000 suicide deaths occur among older adults each year (1). Deaths among older adults account for 33% of these unintentional injury deaths and 19% of suicide deaths among all age groups (1). Nonfatal injuries from these causes are more common in this age group and can lead to long-term health consequences, such as brain injury and loss of independence. This study included 2018 data from the Agency for Healthcare Research and Quality's Healthcare Cost and Utilization Project (HCUP) to determine the prevalence of selected nonfatal injuries among older adults treated in emergency departments (EDs) and hospitals. Injury mechanisms among the leading causes of injury death in older adults were studied, including unintentional falls, unintentional traffic-related motor vehicle crashes, unintentional opioid overdoses, and self-harm (suicidal and nonsuicidal by any mechanism). In 2018, an estimated 2.4 million ED visits and >700,000 hospitalizations from these injuries occurred among adults aged ≥65 years. Unintentional falls accounted for >90% of the selected ED visits and hospitalizations. Injuries among older adults can be prevented (2). Educational campaigns, such as CDC's Still Going Strong* awareness campaign, that use positive messages can encourage older adults to take steps to prevent injuries. Health care providers can help prevent injuries by recommending that older patients participate in effective interventions, including referrals to physical therapy and deprescribing certain medications.†.
Circular RNA circSDHC serves as a sponge for miR-127-3p to promote the proliferation and metastasis of renal cell carcinoma via the CDKN3/E2F1 axis
Authors: Junjie Cen, Yanping Liang, Yong Huang, Yihui Pan, Guannan Shu, Zhousan Zheng, Xiaozhong Liao, Mi Zhou, Danlei Chen, Yong Fang, Wei Chen, Junhang Luo, Jiaxing Zhang
Journal: Molecular Cancer (2021)

There is increasing evidence that circular RNAs (circRNAs) have significant regulatory roles in cancer development and progression; however, the expression patterns and biological functions of circRNAs in renal cell carcinoma (RCC) remain largely elusive. Bioinformatics methods were applied to screen for circRNAs differentially expressed in RCC. Analysis of online circRNAs microarray datasets and our own patient cohort indicated that circSDHC (hsa_circ_0015004) had a potential oncogenic role in RCC. Subsequently, circSDHC expression was measured in RCC tissues and cell lines by qPCR assay, and the prognostic value of circSDHC evaluated. Further, a series of functional in vitro and in vivo experiments were conducted to assess the effects of circSDHC on RCC proliferation and metastasis. RNA pull-down assay, luciferase reporter and fluorescent in situ hybridization assays were used to confirm the interactions between circSDHC, miR-127-3p and its target genes. Clinically, high circSDHC expression was correlated with advanced TNM stage and poor survival in patients with RCC. Further, circSDHC promoted tumor cell proliferation and invasion, both in vivo and in vitro. Analysis of the mechanism underlying the effects of circSDHC in RCC demonstrated that it binds competitively to miR-127-3p and prevents its suppression of a downstream gene, CDKN3, and the E2F1 pathway, thereby leading to RCC malignant progression. Furthermore, knockdown of circSDHC caused decreased CDKN3 expression and E2F1 pathway inhibition, which could be rescued by treatment with an miR-127-3p inhibitor. Our data indicates, for the first time, an essential role for the circSDHC/miR-127-3p/CDKN3/E2F1 axis in RCC progression. Thus, circSDHC has potential to be a new therapeutic target in patients with RCC.
INHIBITION OF APOPTOSIS AND FERROPTOSIS EXERTS HIGHER EFFICACY IN REDUCING CARDIAC ISCHEMIA/REPERFUSION INJURY THAN NECROPTOSIS INHIBITOR IN RATS
Authors: Ying Luo, Suchan Liao, Jun Wu, Busarin Arunsak, Thidarat Jaiwongkam, Juthipong Benjanuwattra, Nattayaporn Apaijai, Siriporn Chattipakorn, Nipon Chattipakorn
Journal: Journal of the American College of Cardiology (2021)
EFFECT OF PEEP ON HEMODYNAMICS IN COVID PATIENTS WITH SHOCK
Authors: Steven M. Hollenberg, Matthew Fata, Joseph Parrillo, Noha Gayed, Taya Glotzer, Ronaldo Go, Elli Gourna-Paleoudis, David Landers, Sameer Jamal, Brent Klinkhammer, Lucy Safi, Neel Shah, Roshan Shah, Jana Tancredi, Zoltan Turi
Journal: Journal of the American College of Cardiology (2021)
Interleukin-6 receptor blockade in patients with COVID-19: placing clinical trials into context
Authors: Federico Angriman, Bruno L Ferreyro, Lisa Burry, Eddy Fan, Niall D Ferguson, Shahid Husain, Shaf H Keshavjee, Enrico Lupia, Laveena Munshi, Samuele Renzi, Onion Gerald V Ubaldo, Bram Rochwerg, Lorenzo Del Sorbo
Journal: The Lancet Respiratory Medicine (2021)
Mechanisms of Cardiovascular Toxicities Associated With Immunotherapies
Authors: Alan H. Baik, Olalekan O. Oluwole, Douglas B. Johnson, Nina Shah, Joe-Elie Salem, Katy K. Tsai, Javid J. Moslehi
Journal: Circulation Research (2021)

Immune-based therapies have revolutionized cancer treatments. Cardiovascular sequelae from these treatments, however, have emerged as critical complications, representing new challenges in cardio-oncology. Immune therapies include a broad range of novel drugs, from antibodies and other biologics, including immune checkpoint inhibitors and bispecific T-cell engagers, to cell-based therapies, such as chimeric-antigen receptor T-cell therapies. The recognition of immunotherapy-associated cardiovascular side effects has also catapulted new research questions revolving around the interactions between the immune and cardiovascular systems, and the signaling cascades affected by T cell activation, cytokine release, and immune system dysregulation. Here, we review the specific mechanisms of immune activation from immunotherapies and the resulting cardiovascular toxicities associated with immune activation and excess cytokine production.
Myeloid-derived suppressor cell subtypes differentially influence T-cell function, T-helper subset differentiation, and clinical course in CLL
Authors: Gerardo Ferrer, Byeongho Jung, Pui Yan Chiu, Rukhsana Aslam, Florencia Palacios, Andrea Nicola Mazzarello, Stefano Vergani, Davide Bagnara, Shih-Shih Chen, Sophia Yancopoulos, Aliki Xochelli, Xiao-Jie Yan, Jan A. Burger, Jacqueline C. Barrientos, Jonathan E. Kolitz, Steven L. Allen, Kostas Stamatopoulos, Kanti R. Rai, Barbara Sherry, Nicholas Chiorazzi
Journal: Leukemia (2021)

Abstract Cancer pathogenesis involves the interplay of tumor- and microenvironment-derived stimuli. Here we focused on the influence of an immunomodulatory cell type, myeloid-derived suppressor cells (MDSCs), and their lineage-related subtypes on autologous T lymphocytes. Although MDSCs as a group correlated with an immunosuppressive Th repertoire and worse clinical course, MDSC subtypes (polymorphonuclear, PMN-MDSC, and monocytic, M-MDSCs) were often functionally discordant. In vivo, PMN-MDSCs existed in higher numbers, correlated with different Th-subsets, and more strongly associated with poor clinical course than M-MDSCs. In vitro, PMN-MDSCs were more efficient at blocking T-cell growth and promoted Th17 differentiation. Conversely, in vitro M-MDSCs varied in their ability to suppress T-cell proliferation, due to the action of TNFα, and promoted a more immunostimulatory Th compartment. Ibrutinib therapy impacted MDSCs differentially as well, since after initiating therapy, PMN-MDSC numbers progressively declined, whereas M-MDSC numbers were unaffected, leading to a set of less immunosuppressive Th cells. Consistent with this, clinical improvement based on decreasing CLL-cell numbers correlated with the decrease in PMN-MDSCs. Collectively, the data support a balance between PMN-MDSC and M-MDSC numbers and function influencing CLL disease course.
Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci
Authors: Charles E. Breeze, Anna Batorsky, Mi Kyeong Lee, Mindy D. Szeto, Xiaoguang Xu, Daniel L. McCartney, Rong Jiang, Amit Patki, Holly J. Kramer, James M. Eales, Laura Raffield, Leslie Lange, Ethan Lange, Peter Durda, Yongmei Liu, Russ P. Tracy, David Van Den Berg, Kathryn L. Evans, William E. Kraus, Svati Shah, Hermant K. Tiwari, Lifang Hou, Eric A. Whitsel, Xiao Jiang, Fadi J. Charchar, Andrea A. Baccarelli, Stephen S. Rich, Andrew P. Morris, Marguerite R. Irvin, Donna K. Arnett, Elizabeth R. Hauser, Jerome I. Rotter, Adolfo Correa, Caroline Hayward, Steve Horvath, Riccardo E. Marioni, Maciej Tomaszewski, Stephan Beck, Sonja I. Berndt, Stephanie J. London, Josyf C. Mychaleckyj, Nora Franceschini
Journal: Genome Medicine (2021)

Abstract Background DNA methylation (DNAm) is associated with gene regulation and estimated glomerular filtration rate (eGFR), a measure of kidney function. Decreased eGFR is more common among US Hispanics and African Americans. The causes for this are poorly understood. We aimed to identify trans-ethnic and ethnic-specific differentially methylated positions (DMPs) associated with eGFR using an agnostic, genome-wide approach. Methods The study included up to 5428 participants from multi-ethnic studies for discovery and 8109 participants for replication. We tested the associations between whole blood DNAm and eGFR using beta values from Illumina 450K or EPIC arrays. Ethnicity-stratified analyses were performed using linear mixed models adjusting for age, sex, smoking, and study-specific and technical variables. Summary results were meta-analyzed within and across ethnicities. Findings were assessed using integrative epigenomics methods and pathway analyses. Results We identified 93 DMPs associated with eGFR at an FDR of 0.05 and replicated 13 and 1 DMPs across independent samples in trans-ethnic and African American meta-analyses, respectively. The study also validated 6 previously published DMPs. Identified DMPs showed significant overlap enrichment with DNase I hypersensitive sites in kidney tissue, sites associated with the expression of proximal genes, and transcription factor motifs and pathways associated with kidney tissue and kidney development. Conclusions We uncovered trans-ethnic and ethnic-specific DMPs associated with eGFR, including DMPs enriched in regulatory elements in kidney tissue and pathways related to kidney development. These findings shed light on epigenetic mechanisms associated with kidney function, bridging the gap between population-specific eGFR-associated DNAm and tissue-specific regulatory context.
日本人対象における冠状動脈アテロームに与えるロスバスタチンの効果を評価するため血管内超音波を用いた研究の論拠およびデザイン COSMOS試験(日本人対象における血管内超音波を用いたロスバスタチンの効果を測定するための冠状動脈効果試験)
Authors: Takayama Tadateru, Hiro Takafumi, Yamagishi Masakazu, Daida Hiroyuki, Saito Satoshi, Yamaguchi Tetsu, Matsuzaki Masunori
Journal: Circulation (2007)
Reducing Skin Toxicities from EGFR Inhibitors with Topical BRAF Inhibitor Therapy
Authors: Mario E. Lacouture, Zev A. Wainberg, Anisha B. Patel, Milan J. Anadkat, Salomon M. Stemmer, Einat Shacham-Shmueli, Egmidio Medina, Galit Zelinger, Noa Shelach, Antoni Ribas
Journal: Cancer Discovery (2021)

Abstract Treatment of cancer with EGFR inhibitors is limited by on-target skin toxicities induced by inhibition of the MAPK pathway. BRAF inhibitors are known to paradoxically activate the MAPK downstream of EGFR, which we confirmed using human skin keratinocytes. We then conducted a phase I clinical trial testing the hypothesis that topical therapy with the BRAF inhibitor LUT014 could improve skin toxicities induced by EGFR inhibitors. Ten patients with metastatic colorectal cancer who had developed acneiform rash while being treated with cetuximab or panitumumab were enrolled in three cohorts. LUT014 was well tolerated, and there were no dose-limiting toxicities. The acneiform rash improved in the 6 patients who started with grade 2 rash in the low and intermediate cohorts. We conclude that topical LUT014 is safe and efficacious in improving rash from EGFR inhibitors, consistent with the mechanism of action inducting paradoxical MAPK activation. Significance: BRAF inhibitor topical therapy could avoid dose reductions of EGFR inhibitors, locally treating the main dose-limiting skin toxicity of this class of agents. This article is highlighted in the In This Issue feature, p. 2113
Associations of Diet Quality and All-Cause Mortality Across Levels of Cardiometabolic Health and Disease: A 7.6-Year Prospective Analysis From the Dutch Lifelines Cohort
Authors: Petra C. Vinke, Gerjan Navis, Daan Kromhout, Eva Corpeleijn
Journal: Diabetes Care (2020)

OBJECTIVE To simultaneously investigate the association of diet quality and all-cause mortality in groups with varying cardiometabolic diseases (CMDs) at baseline. RESEARCH DESIGN AND METHODS From the population-based Lifelines cohort, 40,892 non-underweight participants aged ≥50 years with data on diet quality and confounding factors were included (enrollment 2006–2013). From food-frequency questionnaire data, tertiles of the Lifelines Diet Score were calculated (T1 = poorest, T3 = best diet quality). Four CMD categories were defined: 1) CMD free, 2) type 2 diabetes, 3) one cardiovascular disease (CVD), 4) two or more CMDs. Months when deaths occurred were obtained from municipal registries up until November 2019. Multivariable Cox proportional hazards models were applied for the total population and stratified by CMD categories. RESULTS After a median follow-up of 7.6 years, 1,438 participants died. Diet quality and CMD categories were independently associated with all-cause mortality in crude and adjusted models (P &amp;lt; 0.001). A dose-response relationship of diet quality with all-cause mortality was observed in the total population (Ptrend &amp;lt; 0.001, T2 vs. T3 = 1.22 [1.07–1.41], T1 vs. T3 = 1.57 [1.37–1.80]). In stratified analyses, the association was significant for CMD-free individuals (T1 vs. T3 = 1.63 [1.38–1.93]) and for patients with type 2 diabetes (1.87 [1.17–3.00]) but not for patients with one CVD (1.39 [0.93–2.08]) or multiple CMDs (1.19 [0.80–1.76]). CONCLUSIONS A high-quality diet can potentially lower all-cause mortality risk in the majority of the aging population. Its effect may be greatest for CMD-free individuals and patients with type 2 diabetes. Tailored dietary guidelines may be required for patients with extensive histories of CMDs.
EPINEPHRINE INDUCED MYOCARDIAL INFARCTION: WHEN ANAPHYLACTIC SHOCK PROGRESSES TO STEMI
Authors: Karelys Burgos Irizarry, Jorge Barletta Farias, Javier García Marín, Jonathan Cordero Jiménez, Jorge Ballester Maldonado, Pedro Vargas Otero
Journal: Journal of the American College of Cardiology (2021)
META-ANALYSIS OF CATHETER ABLATION COMPARED WITH DRUG THERAPY AS A FIRST LINE TREATMENT STRATEGY OF PAROXYSMAL ATRIAL FIBRILLATION
Authors: Ahmad Al-Abdouh, Ashish Kumar, Harshvardhan Zala, Mahmoud Barbarawi, Waiel Abusnina, Ahmad Jabri, Monil Majmundar, Saima Karim, Awani Deshmukh, Siva Mulpuru, Abhishek Deshmukh
Journal: Journal of the American College of Cardiology (2021)