tbuckley/cabot-search huggingface dataset:
Possession
Authors: Cecil G. Helman
Journal: Annals of Internal Medicine (2004)

On Being a Doctor3 February 2004PossessionCecil G. Helman, MBChBCecil G. Helman, MBChBFrom London N19 5LW, United Kingdom.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-3-200402030-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail They sit across the desk from me, the young couple, both tense and distracted. I am very new to family practice, and John is almost exactly the same age as I am. We are the same height and shape, and we have the same style of moustache. We are even dressed in a similar way. But there's a pinched, sallow look about his face, as if the mirror I am peering into is blurred and slightly dusty.John and Bridget live with their 2 young children in an outer suburb of London. It's an area of small, identical, semidetached houses, ... Author, Article, and Disclosure InformationAffiliations: From London N19 5LW, United Kingdom.Corresponding Author: Cecil G. Helman, MBChB, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, 2nd Floor, Holborn Union Buildings, Highgate Hill, London N19 5LW, United Kingdom. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 3 February 2004Volume 140, Issue 3Page: 229-230KeywordsBloodEmotionsLiverNursesOxygenSkeletonSmellSurgeonsSurgeryUlcerative colitis ePublished: 3 February 2004 Issue Published: 3 February 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Persistent early systolic reverse coronary flow predicts poor functional recovery in acute myocardial infarction after primary coronary angioplasty: Serial assessment with transthoracic coronary doppler echocardiography Yuichi Nohtomi, Kazushige Nagasawa, Tohru Yamawaki, Kenji Miyata, Ken-ichi Arimura, Isamu Matsuo, Kouichi Kuwata, Shoichi Kondo, Atsushi Sobashima, Akira Yamada, Shuichi Okamatsu. Iizuka Hospital, Iizuka, Fukuoka, Japan
Journal: Journal of the American College of Cardiology (2001)
Orbital Vascular Malformations: Determining Outflow with Valsalva Maneuver-Augmented Computed Tomography Angiography
Authors: Kelsey A. Roelofs, Gary Duckwiler, Bradley Gundlach, Bryan Yoo, Stefania B. Diniz, Liza M. Cohen, Robert A. Goldberg, Daniel B. Rootman
Journal: Ophthalmology (2022)
Developing Drugs for Life-threatening Genetic Diseases
Authors: Rita Rubin
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Engineering an enthesis-like graft for rotator cuff repair: An approach to fabricate highly biomimetic scaffold capable of zone-specifically releasing stem cell differentiation inducers
Authors: Can Chen, Qiang Shi, Muzhi Li, Yang Chen, Tao Zhang, Yan Xu, Yunjie Liao, Shulin Ding, Zhanwen Wang, Xing Li, Chunfeng Zhao, Lunquan Sun, Jianzhong Hu, Hongbin Lu
Journal: Bioactive Materials (2022)

Rotator cuff (RC) attaches to humerus across a triphasic yet continuous tissue zones (bone-fibrocartilage-tendon), termed "enthesis". Regrettably, rapid and functional enthesis regeneration is challenging after RC tear. The existing grafts bioengineered for RC repair are insufficient, as they were engineered by a scaffold that did not mimic normal enthesis in morphology, composition, and tensile property, meanwhile cannot simultaneously stimulate the formation of bone-fibrocartilage-tendon tissues. Herein, an optimized decellularization approach based on a vacuum aspiration device (VAD) was developed to fabricate a book-shaped decellularized enthesis matrix (O-BDEM). Then, three recombinant growth factors (CBP-GFs) capable of binding collagen were synthesized by fusing a collagen-binding peptide (CBP) into the N-terminal of BMP-2, TGF-β3, or GDF-7, and zone-specifically tethered to the collagen of O-BDEM to fabricate a novel scaffold (CBP-GFs/O-BDEM) satisfying the above-mentioned requirements. After ensuring the low immunogenicity of CBP-GFs/O-BDEM by a novel single-cell mass cytometry in a mouse model, we interleaved urine-derived stem cell-sheets into this CBP-GFs/O-BDEM to bioengineer an enthesis-like graft. Its high-performance on regenerating enthesis was determined in a canine model. These findings indicate this CBP-GFs/O-BDEM may be an excellent scaffold for constructing enthesis-like graft to patch large/massive RC tears, and provide breakthroughs in fabricating graded interfacial tissue.
HERG K897T polymorphism and QT interval in a random middle-aged population Eeva Pietil�, Heidi Fodstad, Elmo Niskasaari, P�ivi Laitinen, Heikki Swan, Markku Savolainen, Antero Kes�niemi, Kimmo Kontula, Heikki Huikuri. University of Oulu, Oulu, Finland, University of Helsinki, Helsinki, Finland
Journal: Journal of the American College of Cardiology (2001)
Petites cliniques. (Première série).
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Table of Contents
Authors: Olivier Devuyst, Brad Rovin, Pierre Ronco, Saraladevi Naicker, Chih-Wei Yang, Shang-Jyh Hwang, Bi-Cheng Liu, Jiang-Hua Chen, Vivekanand Jha, Yichun Cheng, Ran Luo, Kun Wang, Meng Zhang, Zhixiang Wang, Christian Krebs, Andreas Schlitzer, Christian Kurts, Midori Sakashita, Tetsuhiro Tanaka, Masaomi Nangaku, Kevin Mccarthy
Journal: Kidney International (2020)
The Regulation of Cytochrome P-450 Gene Expression
Authors: J. Whitlock
Journal: The Annual Review of Pharmacology and Toxicology (1986)

Over the past two decades, deadly coronaviruses, with the most recent being the severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) 2019 pandemic, have majorly challenged public health. The path for virus invasion into humans and other ...Read More
Third Universal Definition of Myocardial Infarction
Authors: Kristian Thygesen, Joseph S Alpert, Allan S Jaffe, Maarten L Simoons, Bernard R Chaitman, Harvey D White, Kristian Thygesen, Joseph S Alpert, Harvey D White, Allan S Jaffe, Hugo A Katus, Fred S Apple, Bertil Lindahl, David A Morrow, Bernard R Chaitman, Peter M Clemmensen, Per Johanson, Hanoch Hod, Richard Underwood, Jeroen J Bax, Jeroen J Bonow, Fausto Pinto, Raymond J Gibbons, Keith A Fox, Dan Atar, L Kristin Newby, Marcello Galvani, Christian W Hamm, Barry F Uretsky, Ph Gabriel Steg, William Wijns, Jean-Pierre Bassand, Phillippe Menasche, Jan Ravkilde, E Magnus Ohman, Elliott M Antman, Lars C Wallentin, Paul W Armstrong, Maarten L Simoons, James L Januzzi, Markku S Nieminen, Mihai Gheorghiade, Gerasimos Filippatos, Russell V Luepker, Stephen P Fortmann, Wayne D Rosamond, Dan Levy, David Wood, Sidney C Smith, Dayi Hu, Jose-Luis Lopez-Sendon, Rose Marie Robertson, Douglas Weaver, Michal Tendera, Alfred A Bove, Alexander N Parkhomenko, Elena J Vasilieva, Shanti Mendis, Jeroen J Bax, Helmut Baumgartner, Claudio Ceconi, Veronica Dean, Christi Deaton, Robert Fagard, Christian Funck-Brentano, David Hasdai, Arno Hoes, Paulus Kirchhof, Juhani Knuuti, Philippe Kolh, Theresa McDonagh, Cyril Moulin, Bogdan A Popescu, Zeljko Reiner, Udo Sechtem, Per Anton Sirnes, Michal Tendera, Adam Torbicki, Alec Vahanian, Stephan Windecker, Joao Morais, Carlos Aguiar, Wael Almahmeed, David O Arnar, Fabio Barili, Kenneth D Bloch, Ann F Bolger, Hans Erik Botker, Biykem Bozkurt, Raffaele Bugiardini, Christopher Cannon, James de Lemos, Franz R Eberli, Edgardo Escobar, Mark Hlatky, Stefan James, Karl B Kern, David J Moliterno, Christian Mueller, Aleksandar N Neskovic, Burkert Mathias Pieske, Steven P Schulman, Robert F Storey, Kathryn A Taubert, Pascal Vranckx, Daniel R Wagner
Journal: Journal of the American College of Cardiology (2012)
The Next Meeting of the American Medical Association.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Report published on factors contributing to the spread of Campylobacter in the European Union
Authors: None Eurosurveillance editorial team
Journal: Eurosurveillance (2010)

Preview this article: Report published on factors contributing to the spread of Campylobacter in the European Union, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/15/33/art19641-en-1.gif
Update in Chronic Obstructive Pulmonary Disease 2020
Authors: Andy I. Ritchie, Jonathon R. Baker, Trisha M. Parekh, James P. Allinson, Surya P. Bhatt, Louise E. Donnelly, Gavin C. Donaldson
Journal: American Journal of Respiratory and Critical Care Medicine (2021)

"Update in Chronic Obstructive Pulmonary Disease 2020." American Journal of Respiratory and Critical Care Medicine, 204(1), pp. 14–22
Book Review Modern Methods of Treatment . By Logan Clendening, M.D. Associate Professor of Medicine, Lecturer on Therapeutics, Medical Department of the University of Kansas; Attending Physician, Kansas City General Hospital; Physician to St. Luke's Hospital, Kansas City, Missouri. C. V. Mosby Co. St. Louis. 1928. 2nd edition. pp. 791. Price $10.00.
Journal: New England Journal of Medicine (1929)
index to advertisers
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PRAGUE
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A single-center comparative surveillance strategies of ctDNA (Signatera), imaging, and CEA in the surveillance of resected colorectal cancer.
Authors: Jaideep Singh Sandhu, Chongkai Wang, Yi-Jen Chen, Dawnyel Chevalier, Sabrina Walia, Jae Y. Kim, Kurt Melstrom, Andreas M Kaiser, Marwan Fakih
Journal: Journal of Clinical Oncology (2022)

200 Background: Signatera (S) assay is a CLIA certified minimal residual disease ctDNA assay that has become widely used for monitoring of disease relapse in patients (pts) with resected colorectal cancer. In a longitudinal study, S+ recurrence (SR) occurred at median &gt; 10 months (mo) prior to radiographic disease recurrence (RDR) in a prospective clinical trial. However, the radiographic surveillance frequency in that study was inadequate by US standard practices. Methods: We retrospectively evaluated, in a single center, the sensitivity (ss), specificity (sp), positive predictive value (ppv) and negative predictive value (npv) of S, CT/MRI imaging (Im), and CEA in curatively resected stage II, III, IV pts against True Disease Recurrence (TDR). We considered TDR as any SR, RDR confirmed by pathology, RDR associated with CEA elevation, or RDR with sequential growth on imaging or regression with chemo. S and CEA were performed Q3 mo x 2 yrs and then Q6 mo x 3 yrs. Im was performed Q3 mo x 2 yrs and then Q6 mo x 3 yrs in resected stage IV, Q6 mo x 2 yrs and then Q yr x 3 in stage III/high-risk stage II, and Q yr x 5 yrs in low-risk stage II. Results: 48 pts underwent curative resection (31 stage II-III, 17 stage IV). 15 patients recurred during surveillance (6 stage II-III, 9 stage IV). The ss, sp, ppv, and npv of S, Im, CEA, and (Im and/or CEA) are tabulated below. S, Im, CEA, and Im or CEA were positive for recurrence at the diagnosis of TDR in 8, 9, 4, and 12, respectively. S sensitivity was poor for lung recurrence with 5/6 pts with lung-only mets (3 confirmed by path) being negative by S at the time of Im relapse. S was negative at the time of CNS recurrence and liver recurrence in 2 pts. 2 Pts with negative imaging at SR developed subsequent liver metastases. 2 Pts, counted as TDR, were SR and remain NED without any therapy, by CEA and Im &gt; 1.5 years from S positivity. Conclusions: S does not appear to provide definitive advantages as a surveillance strategy over standard Im frequency- when performed as per NCCN guidelines. Sensitivity of S is particularly poor for low volume lung-only disease recurrence.[Table: see text]
Update analysis: Clinical outcomes following regionalization of gastric cancer care in a U.S. integrated health care system.
Authors: Swee H. Teh, Robert Li, Teresa Lin, Sharon Shiraga, Yan Li, I-Yeh Gong, Tilak Kumar Sundaresan, Lisa J. Herrinton
Journal: Journal of Clinical Oncology (2022)

265 Background: The role of laparoscopic gastrectomy and D2 lymphadenectomy is not yet fully defined in patients treated with modern perioperative chemotherapy. In 2016, Kaiser Permanente Northern California regionalized gastric cancer care, introducing a regional comprehensive multidisciplinary care team, standardizing staging and chemotherapy, and implementing laparoscopic gastrectomy and D2 lymphadenectomy for eligible patients with curative-intent surgery. We previously reported a retrospective cohort study comparing treatments and outcomes before and after regionalization, including 2-year overall survival. Here we present updated 3-year overall survival. Methods: As we described previously ( https://ascopubs.org/doi/full/10.1200/JCO.21.00480 ), the study included all 1429 patients with gastric cancer diagnosed during January 2010 to May 2018, of whom 942 were pre-regionalization, and 487 were post. Of the 1429, 650 had Stage I-III disease, and 394 patients underwent curative intent gastrectomy. 34.9% received neoadjuvant chemotherapy, and 18.4 % of patients received laparoscopic gastrectomy in the pre-regionalization period. In contrast, 66.2% received neoadjuvant chemotherapy, and 91.8% received laparoscopic gastrectomy with D 2 lymphadenectomy in the post regionalization period (p &lt; 0.0001). Lymph node metastasis was noted in 50.7% and 45.1% pre- and post-regionalization periods, respectively (p = 0.29). Survival was analyzed using Kaplan-Meier analysis with entry on the diagnosis date, the outcome on the death date, and censoring on disenrollment or the end of the study. In this updated analysis, the end of the study was increased by one year to December 31, 2019. Results: The statistical analysis showed no difference in patients’ selection for surgery between the pre-and post-regionalization period and no change in the rate of surgical complications. At three years, overall survival among Stage I-III patients who received surgery was 66.0% in the pre-regionalization cohort and 83.0% in the post-regionalization cohort (p &lt; 0.002), a more significant difference than was observed at two years. Conclusions: The utilization of laparoscopic surgery and radical D2 lymphadenectomy in the era of perioperative chemotherapy continues to demonstrate improved postoperative overall disease survival.[Table: see text]
Radiumtherapy.
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Echocardiographic predictors of mortality in nonischemic cardiomyopathy: Report from the PRAISE-2 echocardiographic substudy Christopher H. Cabell, Eric J. Velazquez, Jean G. Dumesnil, Douglas A. Criger, Robert N. Belkin, Allen B. Miller, Anne B. Cropp, James G. Jollis, Thomas Ryan. Duke Clinical Research Institute, Durham, NC, Pfizer Central Research, Groton, CT
Journal: Journal of the American College of Cardiology (2001)
Single‐cell biology uncovers apoptotic cell death and its spatial organization as a potential modifier of tumor diversity in HCC
Authors: Subreen A. Khatib, Lichun Ma, Hien Dang, Marshonna Forgues, Joon‐Yong Chung, Kris Ylaya, Stephen M. Hewitt, Jittporn Chaisaingmongkol, Mathuros Rucchirawat, Xin Wei Wang
Journal: Hepatology (2022)

Abstract Background and Aims HCC is a highly aggressive and heterogeneous cancer type with limited treatment options. Identifying drivers of tumor heterogeneity may lead to better therapeutic options and favorable patient outcomes. We investigated whether apoptotic cell death and its spatial architecture is linked to tumor molecular heterogeneity using single‐cell in situ hybridization analysis. Approach and Results We analyzed 254 tumor samples from two HCC cohorts using tissue microarrays. We developed a mathematical model to quantify cellular diversity among HCC samples using two tumor markers, cyclin‐dependent kinase inhibitor 3 and protein regulator of cytokinesis 1 as surrogates for heterogeneity and caspase 3 ( CASP3 ) as an apoptotic cell death marker. We further explored the impact of potential dying‐cell hubs on tumor cell diversity and patient outcome by density contour mapping and spatial proximity analysis. We also developed a selectively controlled in vitro model of cell death using CRISPR/CRISPR‐associated 9 to determine therapy response and growth under hypoxic conditions. We found that increasing levels of CASP3 + tumor cells are associated with higher tumor diversity. Interestingly, we discovered regions of densely populated CASP3 + , which we refer to as CASP3 + cell islands, in which the nearby cellular heterogeneity was found to be the greatest compared to cells farther away from these islands and that this phenomenon was associated with survival. Additionally, cell culture experiments revealed that higher levels of cell death, accompanied by increased CASP3 expression, led to greater therapy resistance and growth under hypoxia. Conclusions These results are consistent with the hypothesis that increased apoptotic cell death may lead to greater tumor heterogeneity and thus worse patient outcomes.