tbuckley/cabot-search huggingface dataset:
Dissecting Mycotic RCA Aneurysm Detected on 67Ga Scintigraphy
Authors: Rossana Campos, Grace Yung, Robert Russo, Robert Mansberg
Journal: Clinical Nuclear Medicine (2021)

Abstract A 61-year-old man presented with pneumonia and myocardial infarction on a background of diabetes and end-stage renal failure. Methicillin-resistant Staphylococcus aureus bacteremia was confirmed in the setting of ongoing pyrexia. The patient was referred for a 67 Ga study, which revealed Ga-avid active disease in the pericardial effusion. This was localized further on CT/MRI and coronary angiography to a dissecting right coronary artery aneurysm, which was treated with surgical repair and long-term antibiotic treatment.
PULMONARY ARTERY WEDGE PRESSURE CHANGE WITH PASSIVE LEG RAISE DISCRIMINATES PULMONARY HYPERTENSION-LEFT HEART DISEASE FROM PULMONARY ARTERIAL HYPERTENSION
Authors: Ran Tao, Naga Dharmavaram, Ravi Dhingra, James Runo, Amy M. Chybowski, Adam Gepner, Farhan Raza
Journal: Journal of the American College of Cardiology (2021)
Fertility Preservation in Childhood, Adolescent, and Young Adult Cancer 3 Communication and ethical considerations for fertility preservation for patients with childhood, adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group
Authors: Renee L. Mulder, Anna Font-Gonzalez, Eline van Dulmen-den Broeder, Gwendolyn P. Quinn, Jill P. Ginsberg, E.A.H. Loeffen, C.M. Verhaak, Leontien C.M. Kremer, Julia Inthorn
Journal: The Lancet Oncology (2021)
EFFECT OF IONIS-AGT-LRX IN SUBJECTS WITH UNCONTROLLED HYPERTENSION ON 2-3 MEDICATIONS: RESULTS OF A PHASE 2 STUDY
Authors: Erin Morgan, Yvonne Tami, Kevin Hu, Adam Mullick, Richard Geary, George Bakris, Sotirios Tsimikas
Journal: Journal of the American College of Cardiology (2021)
RISK FACTORS OF ALL-CAUSE MORTALITY AFTER SURGICALLY-TREATED INFECTIVE ENDOCARDITIS: A META-ANALYSIS OF HAZARD RATIOS
Authors: Andreas Tzoumas, Angelos Arfaras-Melainis, Ioannis Loufopoulos, Thomas Vasiloulis, Sanjana Nagraj, Wasla Liaqat, Damianos Kokkinidis, Leonidas Palaiodimos
Journal: Journal of the American College of Cardiology (2021)
Programming to S1PR1 <sup>+</sup> Endothelial Cells Promotes Restoration of Vascular Integrity
Authors: Md Zahid Akhter, Jagdish Chandra Joshi, Vijay Avin Balaji Ragunathrao, Mark Maienschein-Cline, Richard L. Proia, Asrar B. Malik, Dolly Mehta
Journal: Circulation Research (2021)

[Figure: see text].
Locus-Specific Characterization of Human Endogenous Retrovirus Expression in Prostate, Breast, and Colon Cancers
Authors: Margaret C. Steiner, Jez L. Marston, Luis P. Iñiguez, Matthew L. Bendall, Katherine B. Chiappinelli, Douglas F. Nixon, Keith A. Crandall
Journal: Cancer Research (2021)

Abstract Human endogenous retroviruses (HERV) have been implicated in a variety of diseases including cancers. Recent research implicates HERVs in epigenetic gene regulation. Here we utilize a recently developed bioinformatics tool for identifying HERV expression at the locus-specific level to identify differential expression of HERVs in matched tumor-normal RNA-sequencing (RNA-seq) data from The Cancer Genome Atlas. Data from 52 prostate cancer, 111 breast cancer, and 24 colon cancer cases were analyzed. Locus-specific analysis identified active HERV elements and differentially expressed HERVs in prostate cancer, breast cancer, and colon cancer. In addition, differentially expressed host genes were identified across prostate, breast, and colon cancer datasets, respectively, including several involved in demethylation and antiviral response pathways, supporting previous findings regarding the pathogenic mechanisms of HERVs. A majority of differentially expressed HERVs intersected protein coding genes or lncRNAs in each dataset, and a subset of differentially expressed HERVs intersected differentially expressed genes in prostate, breast, and colon cancers, providing evidence towards regulatory function. Finally, patterns in HERV expression were identified in multiple cancer types, with 155 HERVs differentially expressed in all three cancer types. This analysis extends previous results identifying HERV transcription in cancer RNA-seq datasets to a locus-specific level, and in doing so provides a foundation for future studies investigating the functional role of HERV in cancers and identifies a number of novel targets for cancer biomarkers and immunotherapy. Significance: Expressed human endogenous retroviruses are mapped at locus-specific resolution and linked to specific pathways to identify potential biomarkers and therapeutic targets in prostate, breast, and colon cancers.
LIPID-LOWERING IN PSORIASIS REDUCES VASCULAR ENDOTHELIAL INFLAMMATION
Authors: Michael Seth Garshick, Tessa Barrett, Khrystyna Myndzar, Jose Scher, Andrea Neimann, Stuart Katz, Sanja Jelic, Edward Fisher, James Kruegert, Jeffrey Berger
Journal: Journal of the American College of Cardiology (2021)
THE USE OF NATURAL LANGUAGE PROCESSING-BASED ALGORITHMS AND OUTPATIENT CLINICAL ENCOUNTERS FOR WORSENING HEART FAILURE: INSIGHTS FROM THE UTILIZE-WHF STUDY
Authors: Andrew P. Ambrosy, Rishi Parikh, Sue Hee Sung, Anand Narayanan, Rajeev Masson, Phuong-Quang Lam, Kevin Kheder, Alan Iwahashi, Alexander Hardwick, Jesse Fitzpatrick, Harshith Avula, Xian Shen, Navneet Sanghera, Joaquim Cristino, Alan Go
Journal: Journal of the American College of Cardiology (2021)
CARDIOVASCULAR OUTCOME OF LEFT ATRIAL STRAIN IN HEART FAILURE WITH PRESERVED EJECTION FRACTION
Authors: Norifumi Bekki, Hiromasa Hayama, Ran Nagai, Wataru Miyake, Jumpei Yamamoto, Shunsuke Torii, Shuji Kubota, Takashi Nakagawa, Toru Okazaki, Masaya Yamamoto, Osamu Okazaki, Hisao Hara, Yukio Hiroi
Journal: Journal of the American College of Cardiology (2021)
PREVALENCE OF OBSTRUCTIVE CORONARY ARTERY DISEASE ASSESSED BY CORONARY CT ANGIOGRAPHY IN DIFFERENT AGE POPULATION WITH CORONARY ARTERY CALCIUM SCORE OF ZERO
Authors: Suraj Dahal, Francesca Calicchio, April Kinninger, Suvasini Lakshmanan, Venkat Sanjay Manubolu, Ruby Havistin, Khadije Ahmad, Vahid Rezvanizadeh, Ahmed Ghanem, Sajad Hamal, Devin Behjatnia, Thomas Cassilly Crahan, Sion Roy, Matthew Budoff
Journal: Journal of the American College of Cardiology (2021)
Docetaxel and cyclophosphamide as neoadjuvant chemotherapy in HER2- primary breast cancer.
Authors: Katsuhiko Nakatsukasa, Tetsuya Taguchi, Hiroshi Koyama, Seiichi Imanishi, Kouichi Sakaguchi, Yoshihumi Hujita, Yoshimi Oouchi, Mahiro Oohashi, Akiko Okamoto, Asako Hamaoka, Riho Sugimoto, Hitomi Tomita, Ikuya Hujiwara, Kenichirou Hukuda, Midori Morita, Takayuki Matsuda, Tatsuya Kotani, Sadao Kawakami, Yayoi Kadotani
Journal: Journal of Clinical Oncology (2014)

141 Background: Recently, docetaxel plus cyclophosphamide (TC) has been established as a standard regimen for adjuvant chemotherapy in HER2- operable breast cancer. However, the efficacy and tolerability of TC as neoadjuvant chemotherapy (NAC) remains unclear. We performed a prospective study of TC NAC in HER2- primary breast cancer. Methods: Eligible patients had HER2- invasive breast cancer that measured more than 1cm, less than 7cm and N0~N1 clinically between July, 2011 and February, 2014. Four cycles of TC(75 and 600 mg/m 2 ) were administered intravenously every 3 weeks as NAC. We investigated the pathological complete response(pCR) of primary breast tumors. pCR was defined as no histological evidence of invasive carcinoma, or the appearance of only ductal carcinoma in situ. The cut-off value of Ki67 index between luminal A and luminal B was defined 20%. Results: We enrolled 52 patients. The completion rate for 4 cycles of TC was 94.2% ( 49 of 52). Relative dose intensity was 99.1% for TC therapy. Forty nine patients were classified according to breast cancer subtype before the estimation. Overall pCR rate was 16.3 %( 8 of 49 ) . pCR rate for patients with luminal A ( ER+, Ki67 low and HER2- ), luminal B ( ER+, Ki67 high and HER2- ) and triple negative ( ER- and HER2- ) were 0%( 0 of 12 ), 4.3 %( 1 of 23 ) and 50.0 %( 7 of 14 ), respectively pCR was achieved in almost triple negative patients. Conclusions: The pCR rate of TC was not so high, regardless of the high completion rate. In this study, TC was effective against triple negative subtype, showing a high pCR rates, compared with luminal subtype. In conclusion, the efficacy of TC NAC in HER2- primary breast cancer is limited, and triple negative subtype might be the good target. Clinical trial information: UMIN000013261.
OUTCOMES OF COVID-19 IN PATIENTS WITH CARDIOVASCULAR DISEASE
Authors: Chau N. Vu, Viviana Zlochiver, Ana Cristina Perez Moreno, Suhail Allaqaband, A. Jamil Tajik, Bijoy Khandheria, Tanvir Bajwa, M. Fuad Jan
Journal: Journal of the American College of Cardiology (2021)
ACETYLCHOLINE RECEPTOR AGONISTS ATTENUATE DOXORUBICIN-INDUCED CARDIAC DYSFUNCTION AND AUTONOMIC IMBALANCE VIA IMPROVING MITOCHONDRIAL FUNCTION IN RATS
Authors: Nanthip Prathumsap, Benjamin Ongnok, Khuanjing Thawatchai, Apiwan Arinno, Chayodom Maneechote, Nattayaporn Apaijai, Titikorn Chunchai, Krekwit Shinlapawittayatorn, Busarin Arunsak, Thidarat Jaiwongkam, Sasiwan Kerdphoo, Siriporn Chattipakorn, Nipon Chattipakorn
Journal: Journal of the American College of Cardiology (2021)
SARS-COV-2 VIRAL LOAD AND CARDIAC INJURY ARE INDEPENDENT AND INCREMENTAL PREDICTORS OF IN-HOSPITAL MORTALITY
Authors: Omar Chehab, Said El Zein, Adel Elmoghrabi, Joseph Sebastian, Tyler Mumm, Adnan Halboni, Samer Alkassis, Nivine El-Hor, Tushar Mishra, Alexandros Briasoulis, Pranatharthi Chandrasekar, Aiden Abidov
Journal: Journal of the American College of Cardiology (2021)
THE EVOLUTION OF RENAL FUNCTION IS NOT IMPACTED BY THE THERAPEUTIC MODALITY OF CORONARY ARTERY DISEASE IN DIABETIC PATIENTS. MASS REGISTRY 10-YEAR FOLLOW-UP
Authors: Daniel Valente Batista, Eduardo Lima, Whady Hueb, Jaime Linhares Filho, Eduardo Martins, Paulo Rezende, Jose Ramires, Cibele Garzillo, Roberto Kalil-Filho, Carlos Serrano
Journal: Journal of the American College of Cardiology (2021)
ASSESSING THE ROLE OF TRANSESOPHAGEAL ECHO IN PATIENTS WITH STAPHYLOCOCCUS AUREUS BACTEREMIA IN ADESIGNATED MEDICALLY UNDERSERVED AREA
Authors: Wagih Zayed, Daniel Fernandez, Gloriana Madrigal, Yomary Yimenez, Alice Lee, Judith Berger, Salim Baghdadi
Journal: Journal of the American College of Cardiology (2021)
Juvenile hormone drives the maturation of spontaneous mushroom body neural activity and learned behavior
Authors: Sarah G Leinwand, Kristin Scott
Journal: Neuron (2021)

Mature behaviors emerge from neural circuits sculpted by genetic programs and spontaneous and evoked neural activity. However, how neural activity is refined to drive maturation of learned behavior remains poorly understood. Here, we explore how transient hormonal signaling coordinates a neural activity state transition and maturation of associative learning. We identify spontaneous, asynchronous activity in a Drosophila learning and memory brain region, the mushroom body. This activity declines significantly over the first week of adulthood. Moreover, this activity is generated cell-autonomously via Cacophony voltage-gated calcium channels in a single cell type, α'/β' Kenyon cells. Juvenile hormone, a crucial developmental regulator, acts transiently in α'/β' Kenyon cells during a young adult sensitive period to downregulate spontaneous activity and enable subsequent enhanced learning. Hormone signaling in young animals therefore controls a neural activity state transition and is required for improved associative learning, providing insight into the maturation of circuits and behavior.
ALTERED NEUROLOGICAL STATUS, INTRACRANIAL HEMORRHAGE AND SEVERE INTRACRANIAL HYPERTENSION COMPLICATING POST-TRANSPLANT CARE: A DIAGNOSTIC DILEMMA
Authors: Xiaoxiao Qian, Leonard Genovese, Tushina Jain, Mehul Desai, Shashank Sinha, Lauren Cooper, Mitchell Psotka, Robert Cole, Ramesh Singh, Daniel Tang, Palak Shah
Journal: Journal of the American College of Cardiology (2021)
INTRAVASCULAR ULTRASOUND-DERIVED LEFT MAIN MINIMUM LUMEN AREA AND PLAQUE BURDEN PREDICT 12-YEAR CARDIAC MORTALITY
Authors: Masahiko Noguchi, Fotis Gkargkoulas, Mitsuaki Matsumura, Lak Kotinkaduwa, Xun Hu, Eisuke Usui, Tatsuhiro Fujimura, Fumiyasu Seike, Bjorn Redfors, Khady N. Fall, Ajay Kirtane, Susheel Kodali, Tamim M. Nazif, Ziad A. Ali, Dimitri Karmpaliotis, Sahil Parikh, Michael Collins, Lauren Privitera, LeRoy E. Rabbani, Gregg Stone, Martin Leon, Jeffrey Moses, Gary S. Mintz, Akiko Maehara
Journal: Journal of the American College of Cardiology (2021)
Common Link between Bone and Heart Health in Thalassemia Major
Authors: Antonella Meloni, Cristina Vassalle, Laura Pistoia, Silvia Maffei, Massimo Allò, Crocetta Argento, Alessandra Spiga, Luciana Rigoli, Maria Flavia Fiorenza, Aurelio Maggio, Angelica Barone, Vincenzo Positano, Alessia Pepe
Journal: Blood (2017)
IN-HOSPITAL OUTCOMES AMONG COVID-19 PATIENTS WITH CANCER AND CARDIOVASCULAR DISEASE
Authors: David Tehrani, Asim Rafique, Xiaoyan Wang, Pooja Desai, Alicia Morgans, Joerg Herrmann, Juan Lopez-Mattei, Tomas Neilan, Salim Hayek, Rushi Parikh, Eric Yang
Journal: Journal of the American College of Cardiology (2021)
IMPACT OF SYSTOLIC BLOOD PRESSURE ON HEART FAILURE SYMPTOMS IN PATIENT WITH MODERATE AORTIC STENOSIS
Authors: Mika Maeda, Shunsuke Kagawa, Taku Omori, Goki Uno, Shunsuke Shimada, Florian Rader, Robert J Siegel, Takahiro Shiota
Journal: Journal of the American College of Cardiology (2021)
ADHERENCE TO HEART TEAM RECOMMENDATIONS IN COMPLEX CORONARY ARTERY DISEASE - INSIGHTS FROM A RETROSPECTIVE COHORT
Authors: David McNamara, Ryan Madder, Nabin K. Manandhar Shrestha, DeeAnn Stickland, Denise Busman, John Mulder, Jose Antonio Rios Salcido, Malav Parikh, Stacie Vanoosterhout, Richard McNamara, David Wohns, Stefan Jovinge
Journal: Journal of the American College of Cardiology (2021)
Interplay between diet and gut microbiome, and circulating concentrations of trimethylamine N-oxide: findings from a longitudinal cohort of US men
Authors: Jun Li, Yanping Li, Kerry L Ivey, Dong D Wang, Jeremy E Wilkinson, Adrian Franke, Kyu Ha Lee, Andrew Chan, Curtis Huttenhower, Frank B Hu, Eric B Rimm, Qi Sun
Journal: Gut (2021)

Objectives Gut-produced trimethylamine N-oxide (TMAO) is postulated as a possible link between red meat intake and poor cardiometabolic health. We investigated whether gut microbiome could modify associations of dietary precursors with TMAO concentrations and cardiometabolic risk markers among free-living individuals. Design We collected up to two pairs of faecal samples (n=925) and two blood samples (n=473), 6 months apart, from 307 healthy men in the Men’s Lifestyle Validation Study. Diet was assessed repeatedly using food-frequency questionnaires and diet records. We profiled faecal metagenome and metatranscriptome using shotgun sequencing and identified microbial taxonomic and functional features. Results TMAO concentrations were associated with the overall microbial compositions (permutational analysis of variance (PERMANOVA) test p=0.001). Multivariable taxa-wide association analysis identified 10 bacterial species whose abundance was significantly associated with plasma TMAO concentrations (false discovery rate &lt;0.05). Higher habitual intake of red meat and choline was significantly associated with higher TMAO concentrations among participants who were microbial TMAO-producers (p&lt;0.05), as characterised based on four abundant TMAO-predicting species, but not among other participants (for red meat , P-interaction =0.003; for choline, P-interaction =0.03). Among abundant TMAO-predicting species, Alistipes shahii significantly strengthened the positive association between red meat intake and HbA1c levels ( P-interaction =0.01). Secondary analyses revealed that some functional features, including choline trimethylamine-lyase activating enzymes, were associated with TMAO concentrations. Conclusion We identified microbial taxa that were associated with TMAO concentrations and modified the associations of red meat intake with TMAO concentrations and cardiometabolic risk markers. Our data underscore the interplay between diet and gut microbiome in producing potentially bioactive metabolites that may modulate cardiometabolic health.
The Transcription Factor SLUG Uncouples Pancreatic Cancer Progression from the RAF–MEK1/2–ERK1/2 Pathway
Authors: Faiz Bilal, Enrique J. Arenas, Kim Pedersen, Alex Martínez-Sabadell, Behnam Nabet, Elizabeth Guruceaga, Silvestre Vicent, Josep Tabernero, Teresa Macarulla, Joaquín Arribas
Journal: Cancer Research (2021)

Abstract Activating mutations in some isoforms of RAS or RAF are drivers of a substantial proportion of cancers. The main Raf effector, MEK1/2, can be targeted with several highly specific inhibitors. The clinical activity of these inhibitors seems to be mixed, showing efficacy against mutant BRAF-driven tumors but not KRAS-driven tumors, such as pancreatic adenocarcinomas. To improve our understanding of this context-dependent efficacy, we generated pancreatic cancer cells resistant to MEK1/2 inhibition, which were also resistant to KRAS and ERK1/2 inhibitors. Compared with parental cells, inhibitor-resistant cells showed several phenotypic changes including increased metastatic ability in vivo. The transcription factor SLUG, which is known to induce epithelial-to-mesenchymal transition, was identified as the key factor responsible for both resistance to MEK1/2 inhibition and increased metastasis. Slug, but not similar transcription factors, predicted poor prognosis of pancreatic cancer patients and induced the transition to a cellular phenotype in which cell-cycle progression becomes independent of the KRAS–RAF–MEK1/2–ERK1/2 pathway. SLUG was targeted using two independent strategies: (i) inhibition of the MEK5–ERK5 pathway, which is responsible for upregulation of SLUG upon MEK1/2 inhibition, and (ii) direct PROTAC-mediated degradation. Both strategies were efficacious in preclinical pancreatic cancer models, paving the path for the development of more effective therapies against pancreatic cancer. Significance: This study demonstrates that SLUG confers resistance to MEK1/2 inhibitors in pancreatic cancer by uncoupling tumor progression from KRAS–RAF–MEK1/2–ERK1/2 signaling, providing new therapeutic opportunities.
Another epidemic: racial abuse from patients and the public
Authors: Hoda K Amar
Journal: BMJ (2021)

I was struck by the reports of physical and racial abuse in the emergency department.1 Abuse in healthcare, albeit worsened by the impact of coronavirus, is not a new phenomenon, nor is the epidemic of racial abuse. In 2020, the NHS Staff Survey found that 28.9% of ethnic minority staff had experienced at least one incident of bullying, …
RATIO OF MIXED VENOUS OXYGEN SATURATION-TO-PULMONARY CAPILLARY WEDGE PRESSURE: INSIGHTS FROM THE VETERANS AFFAIRS CLINICAL ASSESSMENT, REPORTING, AND TRACKING PROGRAM
Authors: Dustin Hillerson, Sun Moon Kim, Amrita Srinivasan, Richard Charnigo, Ahmed Abdel-Latif, Matthew Lane, Naoki Misumida, Andrew Kolodziej, John Gurley, David Booth
Journal: Journal of the American College of Cardiology (2021)
DILATED CARDIOMYOPATHY AS THE INITIAL PRESENTATION OF BECKER MUSCULAR DYSTROPHY: A SYSTEMATIC REVIEW OF PUBLISHED CASES
Authors: Gaspar Del Rio-Pertuz, Cristina Morataya, Kanak Parmar, Mostafa Abohelwa, Mohamed Elmassry, Sarah Dubay, Pablo Paz, Erwin Argueta
Journal: Journal of the American College of Cardiology (2021)
PHENOTYPING A NEW HEART FAILURE PATIENT GROUP: METHAMPHETAMINE INDUCED HEART FAILURE WITH REDUCED EJECTION FRACTION (METHREF); SINGLE ADVANCED HEART FAILURE CENTER EXPERIENCE
Authors: Eleni Tseliou, Elizabeth Dranow, Christos Kyriakopoulos, Joseph Taleb, Michael Yaoyao Yin, Line Kemeyou, Stavros Drakos, Josef Stehlik, Omar Wever-Pinzon
Journal: Journal of the American College of Cardiology (2021)
RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation
Authors: Li Jiang, Jiaming Wang, Kai Wang, Hao Wang, Qian Wu, Cong Yang, Yingying Yu, Pu Ni, Yueyang Zhong, Zijun Song, Enjun Xie, Ronggui Hu, Junxia Min, Fudi Wang
Journal: Blood (2021)
Abstract TMIM-083: A TWO-STEP TARGETING STRATEGY UTILIZING GLYCOENGINEERED MESENCHYMAL STEM CELLS FOR OVARIAN CANCER
Authors: Buddhadev Layek, Mihir Shetty, Tim Starr, Swayam Prabha
Journal: Clinical Cancer Research (2019)

Abstract Current tumor targeted drug delivery systems suffer from a lack of selectivity for tumor cells. We propose a two-step tumor targeting strategy to improve the delivery of therapeutic agents to metastatic ovarian cancer. The two-step targeting approach relies on the introduction of non-natural targets (azide functional groups) in the tumor tissue, followed by the delivery of drug-loaded polymeric nanoparticles that are surface modified (with dibenzyl cyclooctyne; DBCO) and have high affinity for these synthetic targets. The objective of the present study was to determine the in vivo efficacy of two-step targeting in a clinically-realistic, patient-derived xenograft (PDX) model of ovarian cancer. The DBCO functionalized, paclitaxel (PTX)-loaded nanoparticles (16.2% w/w PTX; diameter 320 ± 10 nm; and zeta potential -11.5 ± 1.3 mV) were formulated using the FDA approved, biodegradable and biocompatible polymer, poly (DL-lactide-co-glycolide) (PLGA), by emulsion-solvent evaporation method. Glycoengineered mesenchymal stem cells (MSC-Az) were generated by culturing MSCs in N-azidoacetylmannosamine-tetraacylated supplemented media without affecting their viability or tumor homing properties. Anticancer efficacy of MSC-Az mediated two-step targeting strategy was evaluated in female athymic nude mice bearing PDX tumors. Mice with generation 2 tumors were randomly divided into four groups receiving intravenous injection of saline, PTX solution, DBCO-PTX nanoparticles, and intravenous injection of MSC-Az followed by intravenous injection of DBCO-PTX nanoparticles (MSC-Az + DBCO-PTX). We observed significantly reduced tumor growth (p &amp;lt;0.05) and improved survival in the group receiving MSC-Az + DBCO-PTX compared to all other groups. Furthermore, immunohistochemical analysis of the tumor tissues demonstrated that the animals treated with MSC-Az + DBCO-PTX had extensive necrosis compared to other groups, suggesting the potential of MSCs for improved tumor targeting and inhibition. In summary, our results demonstrate the potential of two-step tumor targeting strategy to enhance tumor specific delivery of conventional chemotherapeutic drugs resulting in significantly improved anti–cancer efficacy. Citation Format: Buddhadev Layek, Mihir Shetty, Tim Starr, Swayam Prabha. A TWO-STEP TARGETING STRATEGY UTILIZING GLYCOENGINEERED MESENCHYMAL STEM CELLS FOR OVARIAN CANCER [abstract]. In: Proceedings of the 12th Biennial Ovarian Cancer Research Symposium; Sep 13-15, 2018; Seattle, WA. Philadelphia (PA): AACR; Clin Cancer Res 2019;25(22 Suppl):Abstract nr TMIM-083.