tbuckley/cabot-search huggingface dataset:
Emergency Department Visits for Tick Bites — United States, January 2017–December 2019
Authors: Grace E. Marx, Melanie Spillane, Alyssa Beck, Zachary Stein, Aaron Kite Powell, Alison F. Hinckley
Journal: MMWR Morbidity and Mortality Weekly Report (2021)

The incidence of tickborne diseases in the United States is increasing; reported cases more than doubled from >22,000 in 2004 to >48,000 in 2016 (1). Ticks are responsible for approximately 95% of all locally acquired vectorborne diseases reported by states and the District of Columbia, with Lyme disease accounting for >80% of those cases (2). After a tick bite, persons might seek care at an emergency department (ED) for tick removal and to receive postexposure prophylaxis, which has been shown to effectively prevent Lyme disease when taken within 72 hours of a high-risk bite (3). Using data from CDC's National Syndromic Surveillance Program (NSSP), investigators examined ED tick bite visits during January 2017-December 2019 by sex, age group, U.S. region, and seasonality. During this 36-month period, 149,364 ED tick bite visits were identified. Mean cumulative incidence was 49 ED tick bite visits per 100,000 ED visits overall; incidence was highest in the Northeast (110 per 100,000 ED visits). The seasonal distribution of ED tick bite visits was bimodal: the larger peak occurred during the spring and early summer, and the smaller peak occurred in the fall. This pattern aligns with the seasonality of a known and abundant human-biter, the blacklegged tick, Ixodes scapularis (4). Compared with other age groups, pediatric patients aged 0-9 years accounted for the highest number and incidence of ED tick bite visits; incidence was higher among male patients than among females. Tick bites are not monitored by current surveillance systems because a tick bite is an event that in and of itself is not a reportable condition to health departments. Syndromic surveillance of ED tick bite visits can provide timely information that might predict temporal and geographic risk for exposure to tickborne diseases and guide actionable public health messaging such as avoiding tick habitats, wearing repellent consistently when outdoors, and performing regular tick checks during times of increased tick bite risk.
BETTER LATE THAN NEVER: RARE CARDIOVASCULAR COMPLICATIONS OF UNDIAGNOSED BEHCET'S SYNDROME
Authors: Neiberg De Alcantara Lima, Henrique Carvalho Lima Farias, Ane Karoline Medina Neri, Danielli Lino, Isabela Thomáz Takakura Guedes, Prashant P Patel
Journal: Journal of the American College of Cardiology (2021)
VOLUME, TRENDS AND GEOGRAPHIC VARIATIONS IN TRANSCATHETER AORTIC VALVE REPLACEMENT PROCEDURES BY OPERATOR AMONGST MEDICARE BENEFICIARIES IN THE UNITED STATES
Authors: Timothy Simpson, Babikir Kheiri, Scott Chadderdon, Howard Song, Gurion Lantz, Joaquin Cigarroa, Firas Zahr, Harsh Golwala
Journal: Journal of the American College of Cardiology (2021)
Combination efficacy of ruxolitinib with standard-of-care drugs in CRLF2-rearranged Ph-like acute lymphoblastic leukemia
Authors: Julia W. Bӧhm, Keith C. S. Sia, Connor Jones, Kathryn Evans, Anna Mariana, Ignatius Pang, Tim Failes, Ling Zhong, Chelsea Mayoh, Robert Landman, Robert Collins, Stephen W. Erickson, Greg Arndt, Mark J. Raftery, Marc R. Wilkins, Murray D. Norris, Michelle Haber, Glenn M. Marshall, Richard B. Lock
Journal: Leukemia (2021)
IMPACT OF HIGH-SENSITIVITY C-REACTIVE PROTEIN ON LIPOPROTEIN(A)-ASSOCIATED CARDIOVASCULAR RISK IN CHINESE PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION UNDERWENT PERCUTANEOUS CORONARY INTERVENTION
Authors: Ying Wang, Xiaoxiao Zhao, Peng Zhou, Chen Liu, Zhaoxue Sheng, Jiannan Li, Jinying Zhou, Runzhen Chen, Li Song, Hanjun Zhao, Hongbing Yan
Journal: Journal of the American College of Cardiology (2021)
Abstract 12712: Prognostic Value of Automated Measurement of Mitral Annular Displacement by Speckle-tracking Echocardiography in Asymptomatic Aortic Stenosis Patients With Preserved Left Ventricular Ejection Fraction
Authors: Takeshi Hozumi, Ikuko Teraguchi, Kazushi Takemoto, Suwako Fujita, Teruaki Wada, Manabu Kashiwagi, Kunihiro Shimamura, Yasutsugu Shiono, Akio Kuroi, Yoshiki Matsuo, Yasushi Ino, Takashi Kubo, Atsushi Tanaka, Takashi Akasaka
Journal: Circulation (2019)

Introduction: Management of patients with asymptomatic severe aortic stenosis (AS) patients with preserved left ventricular (LV) ejection fraction (EF) remains controversial. Recent studies have sh...
AN UNUSUAL CAUSE OF ABNORMAL ECHODENSITY IN THE RIGHT ATRIUM
Authors: Kashyap Kela, Chaitanya Rojulpote, Ajinkya Buradkar, Sreekant Avula, Vijay Pratap Singh, Sujithraj Dommaraju, Purveshkumar Patel, Mousa Thalji, Tapan Buch, Pranjal Boruah
Journal: Journal of the American College of Cardiology (2021)
Willpower is a form of, but not synonymous with, self-control
Authors: Ariella Kristal, Julian Zlatev
Journal: Behavioral and Brain Sciences (2021)

Abstract We build on Ainslie's discussion of willpower by highlighting another common misconception in the literature: the conflation of self-control and willpower. In our commentary, we identify this issue and discuss the importance of recognizing willpower not as synonymous with self-control, but rather as a subset of self-control. We describe a set of upstream strategies as more effective alternatives to willpower.
THE ASIAN PERSPECTIVE OF DIMENSIONLESS INDEX IN PATIENTS WITH LOW-GRADIENT SEVERE AORTIC STENOSIS WITH PRESERVED EJECTION FRACTION
Authors: Nicholas Chew, Gwyneth Kong, Nicholas Ngiam, Clare Cheong, Ching Hui Sia, Ivandito Kuntjoro, Ruan Wen, William Kong, Edgar Tay, Tiong Cheng Yeo, Kian Keong Poh
Journal: Journal of the American College of Cardiology (2021)
Capillary Ketone Concentrations at the Time of Colonoscopy: A Cross-Sectional Study With Implications for SGLT2 Inhibitor–Treated Type 2 Diabetes
Authors: Peter S. Hamblin, Rosemary Wong, Elif I. Ekinci, Shoshana Sztal-Mazer, Shananthan Balachandran, Aviva Frydman, Timothy P. Hanrahan, Raymond Hu, Shara N. Ket, Alan Moss, Mark Ng, Sashikala Ragunathan, Leon A. Bach
Journal: Diabetes Care (2021)

A recent case series of diabetic ketoacidosis (DKA) associated with colonoscopy in sodium–glucose cotransporter 2 inhibitor (SGLT2i)-treated diabetes (1) prompted a clinical alert update to include colonoscopy (2). That update advised colonoscopy cancellation when capillary ketone concentrations are >1.0 mmol/L (if blood gas analysis is unavailable) when SGLT2i have not been withheld for 72 h. However, those guidelines were formulated in the absence of data regarding the normal range for capillary ketone concentrations at the time of colonoscopy. Unnecessary colonoscopy cancellation carries risks, including delays in possible cancer detection, and psychological consequences, whereas a ketone cutoff that is too high increases the risk of DKA.

To define a ketone concentration that may serve as an empirical determinant of the need for further investigation, we now report a nondiabetic reference interval for capillary ketone concentrations at the time of colonoscopy from a multicenter observational study conducted between June and December 2020 at four tertiary health services (Alfred, Austin, Eastern, and Western Health) in Melbourne, Australia. Multisite approval was granted by the Alfred Human Research Ethics Committee.

Inclusion criteria for the reference population were community-dwelling, normoglycemic adults undergoing colonoscopy. Exclusion criteria were a history of diabetes, pancreatitis, pancreatic cancer, pancreatic surgery, hemochromatosis, cystic fibrosis, starvation ketosis (defined as fasting >72 h), pregnancy, or the discovery during recruitment of a fasting capillary glucose >5.5 mmol/L (100 mg/dL).

Participants with type 2 diabetes were also recruited to compare capillary ketone concentrations with the reference interval population. Except for physician-adjudicated …
A NOVEL ALGORITHM FOR THE COMPUTATION OF THE DIASTOLIC PRESSURE RATIO IN THE INVASIVE ASSESSMENT OF THE FUNCTIONAL SIGNIFICANCE OF CORONARY ARTERY DISEASE
Authors: Giuseppe Biondi-Zoccai, Micaela Conte, Marcel van‘t Veer, Sebastien Lalancette, Keith Oldroyd, Simone Calcagno, Francesco Versaci
Journal: Journal of the American College of Cardiology (2021)
LONG-TERM PROGNOSTIC FACTORS OF IN-HOSPITAL SURVIVORS WITH ACUTE MYOCARDIAL INFARCTION WITH NON-OBSTRUCTIVE CORONARY ARTERIES
Authors: Seung-Jae Joo, Yeekyoung Ko, Jong Wook Beom, Ki Yung Boo, Jae-Geun Lee, Joon-Hyouk Choi, Song-Yi Kim, Myung Ho Jeong
Journal: Journal of the American College of Cardiology (2021)
AN ENDOSCOPICALLY GUIDED TRANSESOPHAGEAL ECHOCARDIOGRAM-A NOVEL APPROACH TO TRANSCATHETER MITRAL VALVE REPAIR IN THE SETTING OF A ZENKER'S DIVERTICULUM
Authors: Richard Tangel, Vratika Agarwal, John Forrest, Michael Cleman, Ryan Kaple, Prabhjot Singh, Hetal Mehta, Michelle Hughes, Nicholas Tarangelo, Thiruvengadam Muniraj, Paul DaSilva, Samantha Balan
Journal: Journal of the American College of Cardiology (2021)
TRANSCATHETER AORTIC VALVE REPLACEMENT FOR TREATMENT OF MODERATE TO SEVERE AORTIC VALVE REGURGITATION IN THE SETTING OF QUADRICUSPID AORTIC VALVE-A FOUR LEAF CLOVER DILEMMA
Authors: Haytham Allaham, Hani Alkhatib, Adam Zviman, Manu Mysore, Diljon Chahal
Journal: Journal of the American College of Cardiology (2021)
ANGIOTENSIN CONVERTING ENZYME INHIBITORS/ANGIOTENSIN II RECEPTOR BLOCKERS VERSUS ANGIOTENSIN RECEPTOR-NEPRILYSIN INHIBITORS: A RETROSPECTIVE ANALYSIS ON HOSPITAL READMISSIONS FOR HEART FAILURE
Authors: Jennifer L. Nickol, Linnea Lebaron, Walter B. Rentrop, Jared Mullins, Dantwan Smith, Cody Stroupe
Journal: Journal of the American College of Cardiology (2021)
MoS2-based nanocomposites for cancer diagnosis and therapy
Authors: Jianling Wang, Lihua Sui, Jia Huang, Lu Miao, Yubing Nie, Kuansong Wang, Zhichun Yang, Qiong Huang, Xue Gong, Yayun Nan, Kelong Ai
Journal: Bioactive Materials (2021)

Molybdenum is a trace dietary element necessary for the survival of humans. Some molybdenum-bearing enzymes are involved in key metabolic activities in the human body (such as xanthine oxidase, aldehyde oxidase and sulfite oxidase). Many molybdenum-based compounds have been widely used in biomedical research. Especially, MoS2-nanomaterials have attracted more attention in cancer diagnosis and treatment recently because of their unique physical and chemical properties. MoS2 can adsorb various biomolecules and drug molecules via covalent or non-covalent interactions because it is easy to modify and possess a high specific surface area, improving its tumor targeting and colloidal stability, as well as accuracy and sensitivity for detecting specific biomarkers. At the same time, in the near-infrared (NIR) window, MoS2 has excellent optical absorption and prominent photothermal conversion efficiency, which can achieve NIR-based phototherapy and NIR-responsive controlled drug-release. Significantly, the modified MoS2-nanocomposite can specifically respond to the tumor microenvironment, leading to drug accumulation in the tumor site increased, reducing its side effects on non-cancerous tissues, and improved therapeutic effect. In this review, we introduced the latest developments of MoS2-nanocomposites in cancer diagnosis and therapy, mainly focusing on biosensors, bioimaging, chemotherapy, phototherapy, microwave hyperthermia, and combination therapy. Furthermore, we also discuss the current challenges and prospects of MoS2-nanocomposites in cancer treatment.
BASELINE CARDIAC TROPONIN T, CLINICAL OUTCOMES AND VERICIGUAT TREATMENT EFFECT IN HEART FAILURE WITH REDUCED EJECTION FRACTION STUDY: INSIGHTS FROM THE VICTORIA TRIAL
Authors: Christopher R. DeFilippi, Wendimagegn Alemayehu, Adriaan Voors, David Kaye, Kevin Anstrom, Javed Butler, Justin Ezekowitz, Adrian Hernandez, Joerg Koglin, Carolyn Lam, Burkert Pieske, Piotr Ponikowski, Lothar Roessig, Stephen Seliger, Cynthia Westerhout, Paul Armstrong, Christopher O’Connor
Journal: Journal of the American College of Cardiology (2021)
COMPARISON OF OUTCOMES IN HOSPITALIZATIONS FOR HEART TRANSPLANT WITH AND WITHOUT OBESITY: ANALYSIS OF NATIONAL INPATIENT SAMPLE 2004-2014
Authors: Abdul Mannan Khan Minhas, Huzefa Bhopalwala, Nakeya Dewaswala, Anum Akhlaq, Shakeel Jamal, Muhammad Khan, Asim Kichloo, Muhammad Osama Muslim
Journal: Journal of the American College of Cardiology (2021)
Should all pregnant women be offered testing for group B streptococcus?
Authors: Kate F Walker, Jane Plumb, Jim Gray, Jim G Thornton, Anthony J Avery, Jane P Daniels
Journal: BMJ (2021)

### What you need to know

Introducing routine testing for group B streptococcus (GBS) for all women in late pregnancy would likely reduce cases of early onset infection in their newborns, but might also increase the number of women given antibiotics during labour.

One in five pregnant women carries GBS in the gut or genital tract, and more than half of them will pass it to their child during pregnancy, labour (most commonly), or after birth.1 Most babies exposed to maternal GBS remain well, but one in 1750 newborns in the UK and Republic of Ireland develops early onset GBS infection, mostly pneumonia and sepsis. Each year in the UK about 40 babies die from GBS infection, and one in 14 of the survivors has a long term disability.1 Babies born preterm are at higher risk of serious infection and death.2

Low quality evidence shows …
cAMP Imaging at Ryanodine Receptors Reveals β <sub>2</sub> -Adrenoceptor Driven Arrhythmias
Authors: Filip Berisha, Konrad R. Götz, Jörg W. Wegener, Sören Brandenburg, Hariharan Subramanian, Cristina E. Molina, André Rüffer, Johannes Petersen, Alexander Bernhardt, Evaldas Girdauskas, Christiane Jungen, Ulrike Pape, Axel E. Kraft, Svenja Warnke, Diana Lindner, Dirk Westermann, Stefan Blankenberg, Christian Meyer, Gerd Hasenfuß, Stephan E. Lehnart, Viacheslav O. Nikolaev
Journal: Circulation Research (2021)

[Figure: see text].
Rapid Parallel Adaptation to Anthropogenic Heavy Metal Pollution
Authors: Alexander S T Papadopulos, Andrew J Helmstetter, Owen G Osborne, Aaron A Comeault, Daniel P Wood, Edward A Straw, Laurence Mason, Michael F Fay, Joe Parker, Luke T Dunning, Andrew D Foote, Rhian J Smith, Jackie Lighten
Journal: Molecular Biology and Evolution (2021)

Abstract The impact of human-mediated environmental change on the evolutionary trajectories of wild organisms is poorly understood. In particular, capacity of species to adapt rapidly (in hundreds of generations or less), reproducibly and predictably to extreme environmental change is unclear. Silene uniflora is predominantly a coastal species, but it has also colonized isolated, disused mines with phytotoxic, zinc-contaminated soils. To test whether rapid, parallel adaptation to anthropogenic pollution has taken place, we used reduced representation sequencing (ddRAD) to reconstruct the evolutionary history of geographically proximate mine and coastal population pairs and found largely independent colonization of mines from different coastal sites. Furthermore, our results show that parallel evolution of zinc tolerance has occurred without gene flow spreading adaptive alleles between mine populations. In genomic regions where signatures of selection were detected across multiple mine-coast pairs, we identified genes with functions linked to physiological differences between the putative ecotypes, although genetic differentiation at specific loci is only partially shared between mine populations. Our results are consistent with a complex, polygenic genetic architecture underpinning rapid adaptation. This shows that even under a scenario of strong selection and rapid adaptation, evolutionary responses to human activities (and other environmental challenges) may be idiosyncratic at the genetic level and, therefore, difficult to predict from genomic data.
Abstract 13498: Reperfusion Therapy With Rapamycin Prevents Myocardial Ischemic Injury, Through Activation of AKT and ERK
Authors: Scott M Filippone, Sean K Roh, Fadi N Salloum, Rakesh C Kukreja, Anindita Das
Journal: Circulation (2015)

Background: The selective inhibitor of mammalian target of rapamycin (mTOR), rapamycin (RAPA), has been shown to exert preconditioning-like cardioprotective effects against ischemia/reperfusion (I/R) injury. Two distinct mTOR complexes (mTORC1 and mTORC2) differentially regulate cardiomyocyte apoptosis and tissue damage following myocardial infarction. We hypothesized that reperfusion therapy with RAPA would reduce myocardial infarct size through differential modulation of mTOR complexes and MAP kinases. Methods and Results: Adult C57BL mice were subjected to 30 min of ischemia via left anterior descending coronary artery ligation followed by reperfusion for 24 hr. RAPA (0.25 mg/kg) or 10% DMSO (volume-matched control) was administered via intra-cardiac injection at the onset of reperfusion. Post I/R survival (90%) and cardiac function (fractional shortening, FS: 26.9±2.6%) were improved in RAPA-treated mice compared to control (survival: 60%, FS:16.7±3.2%). Additionally, RAPA caused significant reduction in myocardial infarct size (Fig. 1A), measured by tetrazolium chloride staining, and apoptosis (Fig. 1B) in peri-infarct regions, assessed by TUNEL staining. Western blot analysis revealed that RAPA restored Akt473 phosphorylation (target of mTORC2), but reduced ribosomal protein S6 phosphorylation (target of mTORC1) following I/R injury (Fig. 1C). The protective effect of RAPA was associated with increased phosphorylation of ERK1/2 and decreased phosphorylation of P38 (Fig. 1D). RAPA also attenuated pro-apoptotic protein Bax, in concert with increased pro-survival Bcl2 to Bax ratio (Fig. 1E). Conclusion: Reperfusion therapy with RAPA protects hearts against I/R injury by selective activation of mTORC2 and ERK with concurrent inhibition of mTOC1 and P38. We propose that RAPA could be a novel treatment strategy to modulate mTOR complexes and MAP kinase signaling for attenuation of reperfusion injury in the heart.
An Evolutionary Portrait of the Progenitor SARS-CoV-2 and Its Dominant Offshoots in COVID-19 Pandemic
Authors: Sudhir Kumar, Qiqing Tao, Steven Weaver, Maxwell Sanderford, Marcos A Caraballo-Ortiz, Sudip Sharma, Sergei L K Pond, Sayaka Miura
Journal: Molecular Biology and Evolution (2021)

Global sequencing of genomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has continued to reveal new genetic variants that are the key to unraveling its early evolutionary history and tracking its global spread over time. Here we present the heretofore cryptic mutational history and spatiotemporal dynamics of SARS-CoV-2 from an analysis of thousands of high-quality genomes. We report the likely most recent common ancestor of SARS-CoV-2, reconstructed through a novel application and advancement of computational methods initially developed to infer the mutational history of tumor cells in a patient. This progenitor genome differs from genomes of the first coronaviruses sampled in China by three variants, implying that none of the earliest patients represent the index case or gave rise to all the human infections. However, multiple coronavirus infections in China and the United States harbored the progenitor genetic fingerprint in January 2020 and later, suggesting that the progenitor was spreading worldwide months before and after the first reported cases of COVID-19 in China. Mutations of the progenitor and its offshoots have produced many dominant coronavirus strains that have spread episodically over time. Fingerprinting based on common mutations reveals that the same coronavirus lineage has dominated North America for most of the pandemic in 2020. There have been multiple replacements of predominant coronavirus strains in Europe and Asia as well as continued presence of multiple high-frequency strains in Asia and North America. We have developed a continually updating dashboard of global evolution and spatiotemporal trends of SARS-CoV-2 spread (http://sars2evo.datamonkey.org/).
VALVE-IN-VALVE TRANSCATHETER AORTIC-VALVE REPLACEMENT WITH BASILICA IN A PATIENT WITH HISTORY OF EVANS SYNDROME, HEPARIN INDUCED THROMBOCYTOPENIA AND HEMODIALYSIS. IS IT EVEN POSSIBLE?
Authors: Mahmoud Samy Ahmed, Toka Amin, Akhtar Amin, Mouhamed Nashawi, Justin Haloot, Hendre FIchardt, Anand Prasad, Ahmed Almomani
Journal: Journal of the American College of Cardiology (2021)
ASSOCIATION OF PROSTHESIS OVERSIZING OR UNDER SIZINGIN BALLOON-EXPANDABLE TRANSCATHETER AORTIC VALVE REPLACEMENT AND CLINICAL OUTCOMES
Authors: Alexis K. Okoh, Kush Patel, Amy Suhotliv, Chamaka Kalutota, Justin Johannesen, Leonard Lee, Mark Russo, Chunguang Chen
Journal: Journal of the American College of Cardiology (2021)
HIGH-RISK ANATOMICAL FEATURES IN A PATIENT WITH ANOMALOUS ORIGIN OF THE RIGHT CORONARY ARTERY MANAGED WITH PERCUTANEOUS CORONARY INTERVENTION
Authors: Fabio Solis-Jimenez, Montserrat Villalobos Pedroza, Jose Antonio Cornejo Guerra, Alejandro Ezquerra, Jorge Sanchez, Jorge Reyes-Tovilla, Carlos Villegas, Guering Eid-Lidt
Journal: Journal of the American College of Cardiology (2021)
Risk of COVID‐19 in Rheumatoid Arthritis: A National Veterans Affairs Matched Cohort Study in At‐Risk Individuals
Authors: Bryant R. England, Punyasha Roul, Yangyuna Yang, Andre C. Kalil, Kaleb Michaud, Geoffrey M. Thiele, Brian C. Sauer, Joshua F. Baker, Ted R. Mikuls
Journal: Arthritis & Rheumatology (2021)

Objective Rheumatoid arthritis (RA) and its treatments are associated with an increased risk of infection, but it remains unclear whether these factors have an impact on the risk or severity of COVID‐19. The present study was undertaken to assess the risk and severity of COVID‐19 in a US Department of Veterans Affairs (VA) cohort of patients with RA and those without RA. Methods A matched cohort study using national VA data was conducted. Patients diagnosed as having RA were identified among nondeceased individuals who were active in the VA health care system as of January 1, 2020 and who had received care in a VA medical center in 2019; patients for whom no RA diagnostic code was indicated were matched to the RA patients (1:1) by age, sex, and VA site (non‐RA controls). Patients diagnosed as having COVID‐19 and those with severe COVID‐19 (defined as requiring hospitalization or leading to death) were ascertained from a national VA COVID‐19 surveillance database through December 10, 2020. Multivariable Cox models were used to compare the risk of COVID‐19 and COVID‐19 hospitalization or death between RA patients and non‐RA controls, after adjusting for demographic characteristics, comorbidities, health care utilization and access, and county‐level COVID‐19 incidence rates. Results This VA cohort of RA patients and non‐RA controls (n = 33,886 subjects per group) predominantly comprised male patients (84.5%), and the mean age was 67.8 years. During follow‐up, 1,503 patients in the cohort were diagnosed as having COVID‐19; among them, 388 patients had severe COVID‐19 (hospitalization or death), while in 228 patients, the deaths were not related to COVID‐19. In the multivariable model, RA was associated with a higher risk of COVID‐19 (adjusted hazard ratio [HR] 1.25 [95% confidence interval (95% CI) 1.13–1.39]) and a higher risk of COVID‐19 hospitalization or death (adjusted HR 1.35 [95% CI 1.10–1.66]) as compared to non‐RA controls. Use of disease‐modifying antirheumatic drugs and prednisone, as well as self‐reported Black race, self‐reported Hispanic ethnicity, and presence of several chronic conditions, but not seropositivity for RA autoantibodies, were each associated with risk of COVID‐19 and severe COVID‐19 (hospitalization or death). Conclusion Patients with RA are at higher risk of developing COVID‐19 and severe COVID‐19 (leading to hospitalization or death) compared to those without RA. With a risk of COVID‐19 that approaches that of other recognized chronic conditions, these findings suggest that RA patients should be prioritized for COVID‐19 prevention and management strategies.