tbuckley/cabot-search huggingface dataset:
Government Services
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SWEDEN
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Analysis of the gastric microbiome in gastric cancer patients and in non-tumorous patients.
Authors: Eun Joo Bang, Hyuk Soon Choi, Jae Min Lee, Eun Sun Kim, Bora Keum, Yoon Tae Jeen, Hoon Jai Chun
Journal: Journal of Clinical Oncology (2022)

349 Background: Gastric cancer is the fifth most common cancer worldwide and it is the most commonly diagnosed cancer in Korea. The most clearly known microbiologic risk factor is Helicobacter pylori infection. Chronic inflammation of gastric mucosa accelerates a cascade of chronic active gastritis, multifocal atrophy intestinal metaplasia, gastric dysplasia and gastric adenocarcinoma. Studies proved H. pylori reduces microbial diversity, but it is reversible with H. pylori eradication. Thus, we could assume gastric carcinogenesis may not solely depend on H. pylori. In this study, we analyzed and compared gastric microbiome in gastric cancer patients and non-cancer patients to find changes between the two groups. Additionally, we analyzed microbial diversity of cancerous lesions and para-cancerous lesions in the cancer group in an effort to reveal the role of microbiome in carcinogenesis. Methods: Gastric mucosa collected by biopsy during esophagogastroduodenoscopy (EGD) from 10 patients with gastric cancer and 18 non-cancer patients. Gastric biopsies were obtained from the margin of cancer and para-cancerous lesions in cancer patients. In control group, samples were obtained from antrum with normal mucosal morphology. DNA was extracted from the gastric mucosal tissues and 16s rRNA genes were amplified. Then they were analyzed by microbiome analysis program. Results: Higher number of species was detected in the control group (average of 97.75 species) compared to the cancer group (average of 73.4 species). The gastric cancer microbiome was showed reduced microbial diversity compared to that of control group. Fusobacteria was more dominant in cancer group and Rhodobacterales was found more prominent in control group. We compared microbial diversity of the cancer lesion and the para-cancerous lesion within the cancer group and higher number of species was detected in non-tumorous lesion. Conclusions: Gastric microbiome of non-tumorous patients was more diverse and the composition of species was different between the two groups. These results suggest that microbial dysbiosis may be involved in gastric carcinogenesis. Further studies should include more detailed analysis of spatial and temporal composition and the comparison between different pathologic types and tumor location are necessary. Better understanding of microbial differences and changes in healthy and gastric cancer patients could verify the carcinogenesis of gastric cancer.
Comparable anti-CMV responses of transplant donor and third-party CMV-specific T cells for treatment of CMV infection after allogeneic stem cell transplantation
Authors: Xu-Ying Pei, Xue-Fei Liu, Xiang-Yu Zhao, Meng Lv, Xiao-Dong Mo, Ying-Jun Chang, Qian-Nan Shang, Yu-Qian Sun, Yu-Hong Chen, Lan-Ping Xu, Yu Wang, Xiao-Hui Zhang, Kai-Yan Liu, Xiao-Jun Huang
Journal: Cellular and Molecular Immunology (2022)
Hartmann’s procedure versus sigmoidectomy with primary anastomosis for perforated diverticulitis with purulent or fecal peritonitis: Three-year follow-up of a randomised controlled trial
Authors: Pim P. Edomskis, Vincent T. Hoek, Pieter W. Stark, Daniël P.V. Lambrichts, Werner A. Draaisma, Esther C.J. Consten, Willem A. Bemelman, Johan F. Lange
Journal: International Journal of Surgery (2022)

Background The aim of the present study is to present the three years follow-up a randomised controlled trial that compared Hartmann’s Procedure (HP) with sigmoidectomy with primary anastomosis (with or without defunctioning ileostomy) (PA) in a randomised design to determine the optimal treatment strategy for perforated diverticulitis with purulent or fecal peritonitis. Methods Data were prospectively gathered for the first 12 months after randomization and retrospectively collected up to 36 months. The primary long-term endpoint was stoma free rate 36 months after the index procedure. Secondary outcomes were patients with a stoma at 36 months, percentage of stoma reversals, related reinterventions, parastomal/incisional hernia rates, total in hospital days including all readmissions regardless their relation to the intervention, overall morbidity and mortality. Results Three years follow-up was completed in 119 of the originally 130 included patients, with 57 (48%) in the PA-group and 62 (52%) patients in the HP-group. 36 months stoma free rate was significantly better for patients undergoing PA compared with HP (PA 92% vs HP 81%, hazard ratio 2.326 [95% CI 1.538–3.517]; log-rank p < 0·0001). Stoma reversal rates did not significantly differ (PA 31/40(78%) versus HP 45/61(74%), p = 0.814). Overall cumulative morbidity (PA 21/57(36%) versus HP 30/62(48%), p = 0.266) and mortality (PA 6/57(11%) versus HP 7/62 (11%), p = 1.000) did not differ between groups. However, more parastomal hernias occurred in the HP-group (HP 10/62(16%) vs PA 1/57(2%), p = 0.009) and the mean total in hospital days after three years follow-up was significantly lower in the PA-group compared to the HP-group (PA 14 days (IQR 9.5–22.5) versus HP 17 days (IQR 12.5–27.5)), p = 0.025). Conclusion Long-term results showed that in haemodynamically stable, immunocompetent patients primary anastomosis is superior to Hartmann’s procedure as treatment for perforated diverticulitis with respect to long-term stoma free rate, overall hospitalization and parastomal hernias. Highlights Regarding long term outcome Primary anastomosis is the preferred choice for patient with purulent and/or fecal peritonitis. Hartmann’s procedure has a worse stoma free rate, overall hospitalization and more parastomal hernias. Hartmann’s procedure should be avoided in haemodynamically stable and immunocompetent patients.
Method for Cataract Extraction in Parkinsonism
Authors: John G. Bellows
Journal: JAMA (1965)

<h3>To the Editor:—</h3> Dr. Hagmeier is quite correct in stating that you have a quiet patient during surgery with general anesthesia. This is probably why—in a patient with paralysis agitans—it has been the standard procedure up to now, and the one that is most commonly taught. However, his report of 36 out of 157 patients in whom nausea, vomiting, and restlessness were observed is in marked contrast to the rare incidence of such symptoms occurring in patients operated under local anesthesia. It is quite obvious that with general anesthesia the incidence of ocular complications resulting from these symptoms would greatly exceed our "acceptable" norms (Stallard, H.B.:<i>Eye Surgery</i>, ed 3, Baltimore: Williams &amp; Wilkins Company, p 83). This is probably why the vast majority of ophthalmologists throughout the world perform routine cataract extractions employing tranquilizers and antimetics. In reporting this case, I was merely suggesting one alternative to the present
In vitro testing for allergy. Report II of the Allergy Panel. Council on Scientific Affairs
Journal: JAMA (1987)

This report is the third of a series of reports prepared by a multidisciplinary panel appointed by the Council on Scientific Affairs of the American Medical Association. This report reviews the current status of in vitro tests available in the evaluation of immunologic and/or allergic diseases. A discussion of the large number of tests available to measure IgE is followed by an overview of the status of complement assays and tests being developed for evaluation of immune complexes. Cellular assays involving polymorphonuclear cells (basophils, eosinophils) and lymphocytes have increased in use; their appropriate indication and current worth are evaluated, as well as the therapeutic monitoring of theophylline serum concentrations. In the view of the panel, the rapidly proliferating number of in vitro diagnostic tests has great potential for the enhancement of the practice of allergy, but also a potential for misuse. Appropriate use of these tests is the focus of this report.
Which antihypertensive treatment is better for mild to moderate hypertension in pregnancy?
Authors: Danielle Ashworth, Cheryl Battersby, Marcus Green, Pollyanna Hardy, Richard J McManus, Catherine Cluver, Lucy C Chappell
Journal: BMJ (2022)

<h3>Rationale</h3> Individual assessment of airway obstruction in preschool-age children requires sensitive and specific lung function methods with low demand of cooperation. Although the forced oscillation technique (FOT) is feasible in young children, conventional measurements of respiratory impedance (Zrs) have limited diagnostic power in individuals. <h3>Objective</h3> To find descriptors of within-breath Zrs that are sensitive indicators of airway obstruction during tidal breathing in children. <h3>Methods</h3> Zrs was measured with (i) a standard multifrequency FOT (4–26 Hz) to assess the mean values of resistance and reactance for whole breaths and (ii) a 10 Hz signal to track the within-breath changes. Various Zrs measures obtained in healthy children (n=75) and those with acute wheeze (n=31) were investigated with receiver operator characteristic (ROC) analysis. The cut-off values obtained for airway obstruction were then tested in children with recurrent wheeze (n=20) before and after administration of salbutamol. <h3>Results</h3> The largest area under the ROC curve (0.95) was observed for the tidal changes of resistance between the zero-flow values (ΔR). The ΔR cut-off value of 1.42 hPa s/L detected airway obstruction with sensitivity of 92% and specificity of 89% in children with acute wheeze and distinguished children with recurrent wheeze (16/20 above the cut-off value) from healthy children (22/23 below the cut-off value). Furthermore, ΔR significantly decreased after salbutamol in wheezy children but remained unchanged in healthy children. <h3>Conclusions</h3> New lung function measure ΔR is able to detect airway obstruction with high sensitivity and specificity and is suitable for use in lung function testing in young children.
Transfer of unstable patients: dumping or duty?
Authors: O. Jonasson
Journal: JAMA (1987)

The public tax-supported hospitals of this country were established primarily to ensure access to a decent minimum of health care for the poor. Unless and until a system is substituted whereby medical care to the poor in private hospitals is compensated by tax dollars, it is inevitable that indigent patients will be transferred from private to public institutions for financial reasons. The increasingly competitive financial climate of private health care and the inability of private hospitals any longer to shift the costs of uncompensated care to paying patients have resulted in dramatic increases in the numbers of patients transferred to public hospitals in recent years. To make the best of this situation, transfer policies designed to safeguard the patient's welfare have been implemented<sup>1</sup>; compliance is variable but, in general, most parties involved follow the rules. But should this practice be permitted when the patient is in an unstable condition and
Early mortality and morbidity of bilateral versus single internal thoracic artery revascularization: Propensity and risk modeling Demosthenes Katritsis, John Ionnidis, Othon Galanos, Cliff P. Connery, George Drossos, Daniel G. Swistel, Constantine Anagnostopoulos. ATHENS EUROCLINIC ATHENS, Greece
Journal: Journal of the American College of Cardiology (2001)
A Randomized Phase II Study of Azacitidine Combined with Lenalidomide or with Vorinostat Vs. Azacitidine Monotherapy in Higher-Risk Myelodysplastic Syndromes (MDS) and Chronic Myelomonocytic Leukemia (CMML): North American Intergroup Study SWOG S1117
Authors: Mikkael A. Sekeres, Megan Othus, Alan F. List, Olatoyosi Odenike, Richard M. Stone, Steven D. Gore, Mark R. Litzow, Rena Buckstein, Mario r Velasco, Rakesh Gaur, Ehab Atallah, Eyal Attar, Frederick R. Appelbaum, Harry P. Erba
Journal: Blood (2014)
Hypofractionated Radiotherapy for Locally Advanced Non–Small Cell Lung Cancer—Does Size Matter?—Reply
Authors: Elizabeth Zhang-Velten, Puneeth Iyengar, Robert D. Timmerman
Journal: JAMA Oncology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Now and then: lessons from the rollout of ART
Authors: None The Lancet Global Health
Journal: The Lancet Global Health (2021)

June 5 marks 40 years since the US Centers for Disease Control and Prevention first reported cases of the disease that would later become known as AIDS. The early years of the epidemic were defined by fear, illness, and certain death for those infected, with the first antiretroviral treatment (ART), azidothymidine (AZT), being approved by the US Food and Drug Administration in 1987. Yet the road to 26 million people receiving ART around the world in 2020 has been a long one. At the 13th International AIDS Conference in Durban, South Africa, in July 2000, Ugandan HIV/AIDS researcher and physician Peter Mugyenyi asked "Where are the drugs? The drugs are where the disease is not.
Koplik Spots
Authors: Puravoor Jayasree, Karalikkattil T. Ashique, Feroze Kaliyadan
Journal: JAMA Dermatology (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Editorial Board
Authors: Andrew Schachat, Henry Jampel, Ike Ahmed, Douglas Miami, F Tin, Aung Singapore, James Brandt Sacramento, Wiley Chambers, I Washington, Susan Day, San Francisco, William Freeman, La Jolla, David Friedman Baltimore, Glenn Durham, Yoshiaki Kitazawa, Ronald Madison, Richard Alan, Lewis Houston, Maureen Maguire, Steven Philadelphia, New Mccormick, Joel York, Arthur Mueller, David Musch, Ann Arbor, Steven Charlottesville, Joan O'brien Philadelphia, Denis O', Day Nashville, Peter Rubin, West Beach, Refractive Matters, Roger Steinert, Richard Stone Philadelphia, Alan Sugar, M Rohit Varma, Thomas Weingeist Iowa, Richard London, Veronica Managing, Lynn Logan, Patricia Previll, Richard Zorab Vp, Ophthalmic Knowledge, Hal Straus, Franco Recchia Nashville, Debra Shetlar
Journal: Ophthalmology (2010)
Abstract 162: MicroRNAs Mediate the Hemodynamic Regulation of Endothelium-to-Smooth Muscle Signaling
Authors: Jing Zhou, Juanjuan Zhu, Yuefeng Liu, Shu Chien
Journal: Circulation Research (2017)

Vascular endothelial cells (ECs) at arterial branches and curvatures experience disturbed blood flow and induce a quiescent-to-activated phenotypic transition of the adjacent smooth muscle cells (SMCs) and a subsequent smooth muscle hyperplasia. However, the mechanism underlying the flow pattern-specific initiation of EC-to-SMC signaling remains elusive. Our previous study has demonstrated that endothelial microRNA-126-3p (miR-126-3p) acts as a key intercellular molecule to increase turnover of the recipient SMCs, and that its release is reduced by atheroprotective laminar shear (LS) to ECs. In the current study we found that atherogenic oscillatory shear (OS), but not atheroprotective pulsatile shear (PS), promotes the regulated exocytosis, particularly the secretion of non-membrane-bound miR-126-3p and other microRNAs (miRNAs) via the activation of soluble N-ethyl-maleimide-sensitive fusion protein attachment protein receptors (SNAREs), VAMP3 and SNAP23. Quantitative PCR arrays identify 15 EC-secreted miRNAs whose levels in the vesicle-poor supernatant of flow perfusate are differentially regulated (P&lt;0.05) by OS versus PS. The fold changes of 11 miRNAs are either greater than 2.0 or less than 0.5. Knockdown of VAMP3 and SNAP23 reduces the secretion of miR-126-3p and miR-200a-3p, as well as the proliferation, migration, and suppression of contractile markers in SMCs caused by EC-coculture. Pharmacological intervention of mTORC1 in ECs blocks endothelial secretion and EC-to-SMC transfer of miR-126-3p through transcriptional inhibition of VAMP3 and SNAP23. Systemic inhibition of VAMP3 and SNAP23 by rapamycin or periadventitial application of the endocytosis inhibitor dynasore ameliorates the disturbed flow-induced neointimal formation, whereas intraluminal overexpression of SNAP23 aggravates it. Our findings demonstrate the flow-pattern-specificity of SNAREs activation and its contribution to the miRNA-mediated EC-SMC communication, uncovering potential targets for future diagnosis and therapeutic interventions for proliferative vascular diseases.
Response to: ‘Correspondence on ‘Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort’ by Pouletty<i>et al’</i>by Pino<i>et al</i>
Authors: Naim Ouldali, Marie Pouletty, Johanna Lokmer, Cherine Benzouid, Constance Beyler, Anna Deho, Ulrich Meinzer, Albert Faye, Isabelle Melki, Charlotte Borocco, Marion Caseris, Romain Basmaci, Noémie Lachaume, Philippe Bensaid, Samia Pichard, Hanane Kouider, Guillaume Morelle, Irina Craiu, Corinne Pondarre, Arielle Maroni, Mehdi Oualha, Zahir Amoura, Julien Haroche, Juliette Chommeloux, Fanny Bajolle, Stéphane Bonacorsi, Guislaine Carcelain, Isabelle Kone-Paut, Brigitte Bader-Meunier, Caroline Galeotti
Journal: Annals of the Rheumatic Diseases (2020)
Phase 1 Study of the Novel Kinesin Spindle Protein Inhibitor Filanesib + Carfilzomib in Patients with Relapsed and/or Refractory Multiple Myeloma (RRMM)
Authors: Jatin J. Shah, Lei Feng, Sheeba K. Thomas, Donna Weber, Michael Wang, Elisabet E. Manasanch, Kathleen Mendoza, Robert Z. Orlowski
Journal: Blood (2015)
Machine Perfusion in Liver Transplant—Promise and Potential but Need for Guidance as Well
Authors: Ralph C. Quillin, Shimul A. Shah
Journal: JAMA Surgery (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal