tbuckley/cabot-search huggingface dataset:
Clinical Impact of Bridging Therapy Prior to Commercial Chimeric Antigen Receptor (CAR) T-Cell Therapies for Relapsed/Refractory Lymphomas
Authors: Brandon S. Imber, Miguel-Angel Perales, Jessica Flynn, Josel D Ruiz, Sean Devlin, Ana Alarcon Tomas, Carla Hajj, Connie Lee Batlevi, Parastoo B. Dahi, Richard J Lin, Jae H. Park, Michael Scordo, Gunjan L. Shah, Sergio A. Giralt, Craig S. Sauter, M. Lia Palomba, Joachim Yahalom
Journal: Blood (2020)
A Prospective Pilot Study to Evaluate Molecular Changes in the Hematopoietic System after Receipt of Chemotherapy or Radiotherapy and Its Clinical Implications Among Racially Diverse Breast Cancer Survivors: Breast Survivorchip Study
Authors: Monica Peravali, Chidera Nosiri, Christopher S. Hourigan, Christopher Gallagher, Aarthi Shenoy
Journal: Blood (2020)
Inverse association of FCER1A allergy variant in monocytes and plasmacytoid dendritic cells
Authors: Anand Kumar Andiappan, Kia Joo Puan, Bernett Lee, Poh Tuang Yeow, Nurhashikin Yusof, Simon Kebede Merid, Dilip Kumar, Josephine Lum, Shihui Foo, Geraldine Koh, Michael Poidinger, Francesca Zolezzi, De Yun Wang, Erik Melén, Olaf Rotzschke
Journal: Journal of Allergy and Clinical Immunology (2020)
The Value of Follow-up Following Complete Remission with Frontline Chemotherapy for DLBCL
Authors: Sarah Thompson, Tasneem Elnafie, Tatiana Elwes, Wilam Alfred, Alinane Munyenyembe, Kabir Mohammed, Bhupinder Sharma, Ian Chau, David Cunningham, Sunil Iyengar, Dima El-Sharkawi
Journal: Blood (2020)
Implications of Omitting Sentinel Lymph Node Biopsy in Patients Older Than 70 Years
Authors: Ko Un Park, Jose G. Bazan
Journal: JAMA Surgery (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Importance of Flow Cytometry in the Immunophenotyping Characterization of Mantle Cell Lymphoma in State of Rio Grande Do Norte, Brazil
Authors: Aldair Sousa Paiva, Alessandra Suelen Jardim Silva, Lenilton Silva DA Silva Júnior, Gustavo Henrique de Medeiros Oliveira, Hugo Henrique de Freitas Ferreira, Maria das Graças Pereira Araujo, Victor lima Soares, Frank Bahia, Rodrigo Villar Freitas, Taissa Moura Oliveira, Dany GKC Silva, Valéria SF Sales, Hugo Diogenes De Oliveira Paiva, Rodolfo DA Soares, Geraldo Barroso Cavalcanti
Journal: Blood (2020)
AB0045 Periprosthetic bone remodelling and radiographic fixation of a cementless total hip arthroplasty with titanium stem in rheumatoid arthritis and osteoarthritis patients
Authors: T Taketa, H Ohnishi, H Turukami, N Okimoto, M Takeda, S Okabe, T Nakamura
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> New bone formation around cementless stem after total hip arthroplasty is dependent on implant design, material, and mode of porous coating. These osteogenesis patterns are classified as follows, proximal endosteal bone bridging spot welds, increased cortical thickness (cortical hypertrophy) and thin radiodense lines surrounding the tip of the implant (halo pedestal). However, no reports showed the comparison of bone remodelling patterns surrounding stem among diseases: such as osteoarthritis (OA), rheumatoid arthritis (RA), avascular necrosis and neck fracture. <h3>Objectives</h3> The purpose of this study is to clarify whether there are differences of the postoperative bone remodelling pattern around the femoral stem between RA and OA patients. <h3>Methods</h3> Total hip arthroplasty with the Mallory-Head cement less titanium prosthesis has been performed since 1992 in our institute. This tapered stem has plasma spray coating in proximal one third of it. RA group included 18 hips (mean age at operation was fifty-five years old and mean duration of follow-up was 4.6 years). OA group included 70 hips (mean age at operation was fifty-eight years old and mean duration of follow-up was 5.2 years). Anteroposterior radiographs of the hip were made at 6 weeks, 3 months, 6 months, one year and every year after the operation. We evaluated the frequency and time of new bone remodelling appearance around the stem such as spot welds, cortical hypertrophy, and pedestal. We defined that the radiographic signs of instability were progressive subsidence or the presence of radiolucent lines around the porous coating (1). To evaluate the differences in both groups, the Mann-Whitney’s U test and chi-square test were used. P values of less than 0.01 were considered significant. <h3>Results</h3> In both groups, there was no case, which has radiographic sign of instability. Age and intramedurally canal fill of the stem at the operation and follow-up period were not significantly different between RA and OA groups. In endosteal spot welds, the time of its appearance in RA group (2.7 months after operation) was significantly shorter than that in OA group (5.2 months) and the frequency of it did not differ between both groups. However, in halo pedestal, the frequency in RA group (50%) was significantly lower than that in OA group (87%) and the time of its appearance did not differ between both groups. On the other hand, concerning about cortical hypertrophy, time and frequency showed no significant differences between two groups. <h3>Conclusion</h3> We revealed that in RA patients, endosteal spot welds appeared significantly earlier than that in OA patients, and the frequency of halo pedestal was significantly lower than that in OA patients.
Minimal Residual Disease-Driven Treatment Intensification By Sequential Addition of Ibrutinib to Venetoclax in Relapsed/Refractory Chronic Lymphocytic Leukemia: Results of the Monotherapy and Combination Phases of the Improve Study
Authors: Lydia Scarfo, Silvia Heltai, Elisa Albi, Eloise Scarano, Luana Schiattone, Lucia Farina, Gianluca Gaidano, Marina Deodato, Andrea Ferrario, Marina Motta, Gianluigi Reda, Rosaria Sancetta, Marta Coscia, Marco Ladetto, Luca Laurenti, Marzia Varettoni, Eleonora Perotta, Antonella Capasso, Pamela Ranghetti, Maria Colia, Paolo Ghia
Journal: Blood (2020)
HLA class II antigens and tumor necrosis factor (TNF) gene polymorphism in patients with autoimmune cholestatic liver diseases
Authors: Paulo L. Bittencourt, Selma A. Palacios, Eduardo Lr Cancado, Gilda Porta, Alberto Q. Farias, Flair José Carrilho, Maria Lc Marin, Antônio Atílio Laudanna, Jorge Elias Kalil Filho, Anna C. Goldberg
Journal: Hepatology (1999)
<i>PTPN11</i> mutations and Outcomes in Adult Patients with Acute Myeloid Leukemia
Authors: Klaus H. Metzeler, Maja Rothenberg-Thurley, Dennis Görlich, Maria Cristina Sauerland, Annika Maria Dufour, Stephanie Schneider, Marion Subklewe, Jan Braess, Bernhard J. Wörmann, Wolfgang E. Berdel, Utz Krug, Wolfgang Hiddemann, Karsten Spiekermann, Tobias Herold
Journal: Blood (2020)
Comparison of Outcomes of Haploidentical Peripheral Blood Stem Cell Transplantation with Post-Transplant Cyclophosphamide in Older Versus Younger Patients
Authors: Giacomo Adoncecchi, Ambuj Kumar, Rawan Faramand, Hien D. Liu, Farhad Khimani, Asmita Mishra, Michael Nieder, Taiga Nishihori, Lia Perez, Joseph Pidala, Claudio Anasetti, Nelli Bejanyan, Hany Elmariah
Journal: Blood (2020)
Serial Screening for COVID-19 in Asymptomatic Patients Receiving Anticancer Therapy in the United Arab Emirates
Authors: Humaid O. Al-Shamsi, Eric A. Coomes, Khuloud Aldhaheri, Sadir Alrawi
Journal: JAMA Oncology (2020)

This cohort study examines the implementation of a microbiologic screening pilot program in Al Zahra Hospital in the United Arab Emirates for identifying presymptomatic COVID-19 in patients with cancer.
A Study Highlighting the Limited Use of Autologous Hematopoietic Stem Cell Transplant for Fit Elderly Patients with Multiple Myeloma in India
Authors: Swaroop Revannasiddaiah, Prathap Raja Varma, Apoorva Jagadish, Rasmi Palassery, Vinayak V Maka, Nalini Kilara, Deepa Dhanabalan, Kalpana Kumari, Damiano Rondelli, Santhosh Kumar Devadas
Journal: Blood (2020)
Cpi-818, an Oral Interleukin-2-Inducible T-Cell Kinase Inhibitor, Is Well-Tolerated and Active in Patients with T-Cell Lymphoma
Authors: Michael S. Khodadoust, Tatyana A. Feldman, Dok Hyun Yoon, Costas K. Yannakou, Dejan Radeski, Youn H. Kim, Neha Mehta-Shah, Amit Khot, Ryan A. Wilcox, Won Seog Kim, Steven M. Horwitz, Joseph J. Buggy, Andrew Hotson, Craig M. Hill, Brian Munneke, Suresh Mahabhashyam, Richard A. Miller, James W. Janc, Mehrdad Mobasher
Journal: Blood (2020)
Intellectual changes after radiation for children with brain tumors: which brain structures are most important?
Authors: Derek S Tsang, Laurence Kim, Zhihui Amy Liu, Laura Janzen, Mohammad Khandwala, Eric Bouffet, Normand Laperriere, Hitesh Dama, Dana Keilty, Tim Craig, Vijay Ramaswamy, David C Hodgson, Donald Mabbott
Journal: Neuro-Oncology (2020)

Abstract Background The objective of this study was to evaluate the contribution of radiation dose to different intracranial structures on changes in intellectual function for children with brain tumors. Methods We evaluated children with brain tumors treated in 2005–2017 who had longitudinal neuropsychological assessments and available photon dosimetric data (if radiation therapy [RT] given). Full Scale Intelligence Quotient (FSIQ) and index scores were evaluated (perceptual reasoning index [PRI], processing speed index [PSI], verbal comprehension index [VCI], and working memory index [WMI]). Multivariable linear mixed effects models were used to model endpoints, with age at RT and dose to different brain regions as fixed effects and patient-specific random intercepts. P-values (P*) were adjusted for multiple comparisons. Results Sixty-nine patients were included, 56 of whom received RT. Median neuropsychological follow-up was 3.2 years. Right temporal lobe mean dose was strongly associated with decline in FSIQ (P* = 0.005); with each gray increase in mean dose, there was a decrease of 0.052 FSIQ points per year. Dose to 50% (D50) of the supratentorial brain was associated with decline in PSI (P* = 0.006) and WMI (P* = 0.001). Right and left hippocampus D50 were individually strongly associated with declines in VCI (P* = 0.009 for each). Presence of a ventriculoperitoneal shunt decreased FSIQ by 10 points. Conclusions We reported associations between dosimetry to specific brain regions and intellectual outcomes, with suggested avoidance structures during RT planning. These models can help clinicians anticipate changes in neurocognition post-RT and guide selection of an optimal RT plan.
High Incidence of <i>TP53</i> and Epigenetic Modifying Oncogenes Mutations in a Large Cohort of Patients Enrolled in Phase 1 Clinical Trials for Relapsed or Refractory Diffuse Large B-Cell Lymphoma
Authors: Cyril Quivoron, Jean-Marie Michot, Valérie Camara-clayette, Alina Danu, Julien Lazarovici, Clementine Sarkozy, David Ghez, Julien Rossignol, Capucine Baldini, Patricia Martin-Romano, Helene Lecourt, Veronique Vergé, Andrea Varga, Sophie Cotteret, Peggy Dartigues-Cuillères, Christophe Massard, Vincent Ribrag
Journal: Blood (2020)
Comparative Connectomics Reveals How Partner Identity, Location, and Activity Specify Synaptic Connectivity in Drosophila
Authors: Javier Valdes-Aleman, Richard D Fetter, Emily C Sales, Emily L Heckman, Lalanti Venkatasubramanian, Chris Q Doe, Matthias Landgraf, Albert Cardona, Marta Zlatic
Journal: Neuron (2020)

The mechanisms by which synaptic partners recognize each other and establish appropriate numbers of connections during embryonic development to form functional neural circuits are poorly understood. We combined electron microscopy reconstruction, functional imaging of neural activity, and behavioral experiments to elucidate the roles of (1) partner identity, (2) location, and (3) activity in circuit assembly in the embryonic nerve cord of Drosophila. We found that postsynaptic partners are able to find and connect to their presynaptic partners even when these have been shifted to ectopic locations or silenced. However, orderly positioning of axon terminals by positional cues and synaptic activity is required for appropriate numbers of connections between specific partners, for appropriate balance between excitatory and inhibitory connections, and for appropriate functional connectivity and behavior. Our study reveals with unprecedented resolution the fine connectivity effects of multiple factors that work together to control the assembly of neural circuits.
Prevalence Trend and Predictors of Clostridium Difficile Infection in Sickle Cell Disease Patients
Authors: Siddharth Bhesania, Ivan Cancarevic, Kishan Patel, Madiha Zeeshan, Renu Bhandari, Pritika Manaktala, Alena Varantsova, Janki Bhesania, Nima Ghalehsari, Shobha Mandal, Achint Patel, Sonal Paul, Parag Mehta, Eshan Patel
Journal: Blood (2020)
Trial in Progress: A Prospective Phase I/II Trial to Jointly Optimize the Administration Schedule(s) and Dose(s) of Melphalan for Injection (Evomela) As a Preparative Regimen for Autologous Hematopoietic Stem Cell Transplantation in Newly Diagnosed Multiple Myeloma
Authors: Qaiser Bashir, Peter F Thall, Dawen Sui, Cristina Knape, Jitesh Kawedia, Muzaffar H. Qazilbash
Journal: Blood (2020)
AB1064 IMMUNOGLOBULIN G4-RELATED DISEASE (IgG4-RD): CLINICAL AND LABORATORY CHARACTERISTICS, TREATMENT RESPONSES AND PROGNOSIS IN ONE HUNDRED FIVE PATIENTS.
Authors: S. Tsuzuki, K. Setoguchi
Journal: Annals of the Rheumatic Diseases (2020)

Background: IgG4-RD is a systemic fibro-inflammatory condition with incompletely understood that is capable of affecting multiple organs. Objectives: We aimed to investigate clinical and laboratory findings in Japanese patients with IgG4-RD. Methods: Dates on clinical characteristics, laboratory features, and treatment response from patients with IgG4-RD in our hospital were reviewed retrospectively from January 2004 to September 2019. Results: Among 105 patients were diagnosed and treated in our hospital, 48% were female and 88% were biopsy-proven. The median age of the patients was 66 years, and female were younger at their diagnosed age (p=0.04). Their medina duration of follow-up was 45 months. 48% of the patients had allergic history (including sinusitis, asthma, hay fever), younger patients tended to have allergy history. Mean serum IgE was 303 IU/dL (2-4965 IU/dL). Salivary and lacrimal grand involvement (63%) and dacryoadenitis and ocular and orbital inflammatory disease (56%), autoimmune pancratitis type 1 pancreatitis (18%), retroperitoneal fibrosis (16%), aortitis (15%) predominantly occurred. 84% of the patients had serum IgG4 higher than 135mg/dL, and high IgG and IgG4 concentration was associated with lower complements (CH50, C4) levels. Mean serum IgG was 1860 mg/dL (861-8432 mg/dL), and IgG4 was 449mg/dL (28-3210mg/dL). Male patients show higher serum IgG and IgG4 concentrations at baseline (p&lt;0.01). Younger patients and low serum C4 level were associated with necessity of treatment, 60 of them used steroid, and the mean dose of prednisone they used was 30mg. Most of them responded well and tapering steroid. Steroid sparing agents were used in 23% of them. Although 23% of patients relapse as tapering steroid, 15% of them could stop treat with steroid. Retreatment with glucocorticoids is not associated with any factors. There were 14 malignancies in 13 patients during the follow-up period. Conclusion: Our study revealed that IgG4-RD occurred in middle age with allergic disease in Japanese patients. The pattern of head and neck was predominance. For the most part of the patient serum IgG and IgG4 concentrations was high. Serum low complement level could be associated with its diagnosis and necessity of treatment with steroid. Younger patients tend to treat with steroid and they responded well. References: [1]Clin Exp Allergy. 2009;39(4):469. [2]Allergy. 2014 Feb;69(3):399-402. Epub 2013 Dec 31 [3]Rheumatology (Oxford). 2019 May 1;58(5):820-830. [4]Am J Surg Pathol 2010 Dec;34(12):1812-9 [5]Ann Rheum Dis. 2020 Jan;79(1):77-87. [6]Arthritis Res Ther 2018 Apr 10;20(1):65. [7]Intern Med. 2014;53(3):171-6. Disclosure of Interests: None declared
Infused Autograft-Absolute Lymphocyte Count Predicts Superior Survival in Diffuse Large B-Cell Lymphoma Patients Post-Autologous Peripheral Blood Hematopoietic Stem Cell Transplantation: A Matched-Control Study
Authors: Edwin Burgstaler, Luis F. Porrata, Jeffrey L. Winters, Eapen K. Jacob, David J. Inwards, Stephen M. Ansell, Ivana Micallef, Patrick B. Johnston, Jose C Villasboas, Jonas Paludo, Svetomir N. Markovic
Journal: Blood (2020)
Hedgehog signaling promotes medulloblastoma survival via Bcl2
Authors: Eli E. Bar, Aneeka Chaudhry, Charles G. Eberhart
Journal: Cancer Research (2006)

4080  Deregulation of the Hedgehog pathway has been implicated in the development of medulloblastoma (MB), the most frequent malignant brain tumor in children. Transcriptional induction of antiapoptotic factors such as Bcl2 is a major mechanism for apoptosis avoidance in cancer cells. We investigated whether Hedgehog might regulate survival in MB via upregulation of Bcl2. We found that the Hedgehog pathway effectors Gli1 and Gli2 colocalize with Bcl2 in regions of decreased apoptosis in a subset of nodular MB. In addition, Gli1 expression in primary MB significantly correlated with Bcl2 expression (Pearson r=0.75, P=0.01). Transient overexpression of Gli1 and Gli2 induced a Bcl2 transcriptional reporter and increased Bcl2 protein levels, while stable overexpression of Gli1 was associated with increased Bcl2 mRNA. The Hedgehog antagonist cyclopamine blocked expression of the Hh pathway targets PTCH1 and Gli1 and increased apoptosis in DAOY and UW228 MB cells. Apoptotic induction caused by cyclopamine could be rescued in part by enforced expression of Gli1 or Bcl2. Hh pathway blockade also sensitized medulloblastoma to the effects of the pro-apoptotic agent lovastatin. These data demonstrate that Bcl2 is an important mediator of Hh activity in medulloblastoma, and suggest new strategies for combined chemotherapeutic regimens.
Mixed Chimerism after Allogeneic Hematopoietic Stem Cell Transplantation in Patients with β Thalassemia: Impact on Outcome and Risk Factors
Authors: Wanxia Tan, Yuelin He, Xiaoqin Feng, Xuedong Wu, Chunfu Li, Jianyun Liao, Huaying Liu, Xuan Liu, Fuyu Pei, Qiujun Liu, Xiaoting Liu, Yuqiong Ren
Journal: Blood (2020)
Red blood cell transfusion does not increase risk of venous or arterial thrombosis during hospitalization
Authors: Lisa Baumann Kreuziger, Gustaf Edgren, Ronald George Hauser, Daniel Zaccaro, Joseph Kiss, Matt Westlake, Donald Brambilla, Alan E. Mast
Journal: American Journal of Hematology (2020)

Previous observational studies suggest associations between red blood cell (RBC) transfusion and risk for arterial or venous thrombosis. We determined the association between thrombosis and RBC transfusion in hospitalized patients using the Recipient Database from the National Heart Lung and Blood Institute (NHLBI) Recipient Epidemiology and Donor Evaluation Study-III. A thrombotic event was a hospitalization with an arterial or venous thrombosis ICD-9 code and administration of a therapeutic anticoagulant or antiplatelet agent. Patients with history of thrombosis or a thrombosis within 24 hours of admission were excluded. A proportional hazards regression model with time-dependent covariates was calculated. Estimates were adjusted for age, sex, hospital, smoking, medical comorbidities, and surgical procedures. Of 657 412 inpatient admissions, 67 176 (10.2%) received at least one RBC transfusion. Two percent (12927) of patients experienced a thrombosis. Of these, 2587 developed thrombosis after RBC transfusion. In unadjusted analyses, RBC transfusion was associated with an increased thrombosis risk [HR = 1.3 (95% CI 1.23-1.36)]. After adjustment for surgical procedures, age, sex, hospital, and comorbidities, no association between RBC transfusion on risk of venous and arterial thrombosis was found [HR 1.0 (95% CI: 0.96-1.05)]. Thus, RBC transfusion does not appear to be an important risk factor for thrombosis in most hospitalized patients.
CRISPR-Cas9 Knock out of CD5 Enhances the Anti-Tumor Activity of Chimeric Antigen Receptor T Cells
Authors: Inkook Chun, Ki Hyun Kim, Yi-Hao Chiang, Wei Xie, Yong Gu Gu Lee, Raymone Pajarillo, Antonia Rotolo, Olga Shestova, Seok Jae Hong, Mohamed Abdel-Mohsen, Maria Wysocka, Hatcher J. Ballard, David M. Barrett, Avery D. Posey, Daniel Powell, Saar I. Gill, Stephen J. Schuster, Stefan K. Barta, Alain H Rook, Carl H June, Marco Ruella
Journal: Blood (2020)
Distinct Gene Expression Signatures in Patients with Richter's Syndrome and Chronic Lymphocytic Leukemia with Prior Exposure to Ibrutinib
Authors: Hanyin Wang, Shulan Tian, Qing Zhao, Wendy Blumenschein, Jennifer H. Yearley, Charla R. Secreto, Sutapa Sinha, Timothy G. Call, Yucai Wang, Sameer A. Parikh, Saad S. Kenderian, Rong He, Jose F. Leis, Min Shi, Neil E. Kay, Susan L. Slager, Esteban Braggio, Huihuang Yan, Wei Ding
Journal: Blood (2020)
Trends in Industry Payments to Physicians in the United States From 2014 to 2018
Authors: Deborah C. Marshall, Elizabeth S. Tarras, Kenneth Rosenzweig, Deborah Korenstein, Susan Chimonas
Journal: JAMA (2020)

This study uses Medicare Open Payments data to characterize trends in the prevalence and value of physicians’ interactions with industry overall and by specialty between January 2014 and December 2018 after implementation of the federal Open Payments transparency program in 2013.
Abstract 257: Calreticulin Regulates Acetylation in Cardiac Cells During Endoplasmic Reticulum Stress
Authors: Janet R Manning
Journal: Circulation Research (2020)

Background: Myocardial infarction (MI) is exacerbated by endoplasmic reticulum (ER) stress, which contributes to apoptosis signaling and tissue death in cardiomyocytes. Although the calcium-handing protein calreticulin is upregulated during MI, the role of calreticulin in the progression of ER stress remains controversial. We hypothesized that calreticulin expression accelerates ER stress via regulation of the acetylation status of ER proteins, and knockdown reduces pro-apoptotic ER stress. Methods: We examined the expression of calreticulin in human cardiac cells in response to ischemia or thapsigargin-mediated ER stress. To test the effect of calreticulin modulation on cell mortality, we generated a stable partial calreticulin knockdown line in proliferating human cardiomyocyte-derived cells. We further examined the induction and acetylation of ER stress signaling proteins, including proteins in each of the three major pathways that account for ER-stress mediated cell death. Results and Conclusions: Calreticulin is upregulated in human ischemic heart failure cardiac tissue, as well as simulated hypoxia and reoxygenation and thapsigargin-mediated ER stress. It was found that partial knockdown protects against the expression of caspase 12, CHOP, and reduces thapsigargin-driven TUNEL staining. In addition, significant changes in the acetylation of ER stress proteins and the expression of the deacetylase SIRT1 were observed. These data shed light on the role that calreticulin plays in apoptosis signaling during ER stress in cardiac cells.