tbuckley/cabot-search huggingface dataset:
AB0184 SCREENING FOR DEPRESSION IN A GROUP OF TUNISIAN PATIENTS WITH RHEUMATOID ARTHRITIS
Authors: M. Sellami, S. Kammoun, S. Miladi, A. Fazaa, L. Souabni, K. Ouenniche, S. Kassab, S. Chekili, K. Ben Abdelghani, A. Laatar
Journal: Annals of the Rheumatic Diseases (2021)

Background: Depression is thought to be common comorbidity in patients with rheumatoid arthritis (RA), which is one of the most frequent chronic inflammatory diseases. Objectives: This study aimed to screen for depression in RA patients, and study its relation to social and clinical parameters, as well as disease activity. Methods: Single-center cross-sectional study, involving patients with RA, according to ACR/EULAR criteria 2010, using the original Beck Depression Inventory (BDI) as a screening tool for depression: measures of 0–9 indicated that a patient was not depressed, 10–18 indicated mild to moderate depression, 19–29 indicated moderate to severe depression and 30–63 indicated severe depression. Results: Sixty-five patients were included (57 F / 8 M). The average age was 55 years [23-73]. The mean duration of the disease was 11.75 years [1-25]. Half of the patients had precarious socioeconomic conditions and no social security. Forty-two patients were unemployed. Seventeen percent of them experienced grief by losing a close family member. Both rheumatoid factor and anti-citrullinated peptides antibodies were positive in 83.1 % of cases. RA was erosive in 78.5% of cases, and deformed in 21.5 % of cases. Almost half of the patients (52.3 %) were followed for at least another chronic disease. Forty-eight percent of patients were on Methotrexate with an average weekly dose of 15.3 mg/week [10-22.5], 10% on Leflunomide, 10% on Sulfasalazine, and 45% on biotherapy. The analysis of BDI scores showed that 64.6 % of patients suffered from depression: mild to moderate in 35.4 % of cases, moderate to severe in 21.5% of cases and severe in 7.7% of cases. Depression was significantly associated with precarious socioeconomic conditions (p=0.018). A correlation between the BDI score and the Disease Activity Score (DAS28) as well as the Health Assessment Questionnaire was noted (p = 0.045 and p = 0.02, respectively). There were no statistically significant associations with the other studied data. Conclusion: Depression was frequent among RA patients. Our study suggests that better control of the disease may reduce the incidence of depression within this group of patients. References: [1]Beck, A.T., Ward, C., &amp; Mendelson, M. (1961). “Beck Depression Inventory (BDI)”. Archives of General Psychiatry, 4, 561-571. Disclosure of Interests: None declared
POS0519 BONE MINERAL DENSITY, LEAN AND FAT MASS IN POSTMENOPAUSAL WOMEN WITH RHEUMATOID ARTHRITIS
Authors: N. Toroptsova, O. Dobrovolskaya, A. Feklistov, O. Nikitinskaya, A. Efremova, N. Demin
Journal: Annals of the Rheumatic Diseases (2021)

Background: The relationship between lean mass (LM), fat mass (FM) and bone mineral density (BMD) remains controversial. Some population studies have emphasized the positive association between them, while others have found an inverse relationship. RA patients are characterized by a decrease in muscle mass and an increase in fat mass. Such changes in body composition may be associated with low BMD. Objectives: To study the relationship between BMD, LM and FM in postmenopausal women with RA. Methods: 68 postmenopausal women with RA (median age 59 [54; 63] years) were included in the study. BMD and body composition were evaluated using two-energy X-ray absorptiometry. Correlation analysis between body composition parameters and BMD was performed with the Spearman method, correlation coefficients R for p&lt;0.05 are presented. Results: The average L1-L4 BMD was 0,92±0,16 g/cm 2 , total hip BMD - 0,84±0,15 g/cm 2 and femoral neck - 0,73±0,13 g/cm 2 . 33 (48.5%) women had osteopenia, and 17 (25.0%) - osteoporosis (OP). Low appendicular LM was found in 5 (7.4%) and low appendicular muscle index (appendicular LM/height 2 , AMI) – in 10 (14.7%) patients. Overfat was revealed in 47 (69.1%) women, but only 20 (29.4%) women had BMI corresponding to obesity. The positive correlations between BMD in L1-L4, total hip and femoral neck regions and body weight (R=0.46, R=0.56 and R=0.50, respectively), trunk fat (R=0.4, R=0.51 and R=0.37, respectively), total FM (R=0.27, R=0.43 and R=0.34, respectively), trunk LM (R=0.55, R=0.54 and R=0.51, respectively), total LM (R=0.51, R=0.50 and R=0.52, respectively), appendicular LM (R=0.31, R=0.29 and R=0.37, respectively) and AMI (R=0.26, R=0.33 and R=0.51, respectively) were found out. In the multivariate linear regression analysis total LM was associated with BMD of lumbar spine (β=0.638, p=0.001) and total hip (β=0.473, p=0.008), and AMI - with femoral neck BMD (β=0.360; p=0.014). We found that FM hadn’t a significant effect on BMD in any region. Conclusion: 73.5% of patients with RA had a reduced BMD, and 14.7% women – low AMI. LM was positively associated with BMDs in different regions of interest, but FM had no effect on BMD. Further researches are needed to identify associations between body composition, inflammatory activity and bone health in patients with RA. Disclosure of Interests: None declared
Depleting plasmacytoid dendritic cells reduces local type I interferon responses and disease activity in patients with cutaneous lupus
Authors: Jodi L. Karnell, Yanping Wu, Nanette Mittereder, Michael A. Smith, Michele Gunsior, Li Yan, Kerry A. Casey, Jill Henault, Jeffrey M. Riggs, Simone M. Nicholson, Miguel A. Sanjuan, Katherine A. Vousden, Victoria P. Werth, Jörn Drappa, Gabor G. Illei, William A. Rees, John N. Ratchford, W. Winn Chatham, Vishala Chindalore, Ramesh Gupta, Slawomir Jeka, Alan Kivitz, Theresa Lawrence Ford, Anne Marano, Jose Luis Marenco de la Fuente, Steven Mathews, Adam Reich, Alla Rudinskaya, Lidia Rudnicka, Antonio Terrelonge
Journal: Science Translational Medicine (2021)

VIB7734 depletes plasmacytoid dendritic cells and demonstrates clinical benefit in patients with cutaneous lupus.
OP0074 A FRAMEWORK OF POTENTIAL INTERVENTIONS TO ACCELERATE GENDER-EQUITABLE CAREER ADVANCEMENT IN ACADEMIC RHEUMATOLOGY
Authors: P. V. Ovseiko, L. Gossec, L. Andreoli, U. Kiltz, L. Van Mens, N. Hassan, M. Van der Leeden, H. J. Siddle, A. Alunno, I. Mcinnes, N. Damjanov, F. Apparailly, C. Ospelt, I. Van der Horst-Bruinsma, E. Nikiphorou, K. Druce, Z. Szekanecz, A. Sepriano, T. Avcin, G. Bertsias, G. Schett, A. M. Keenan, L. C. Coates
Journal: Annals of the Rheumatic Diseases (2021)

Background: A growing number of professional societies in clinical and medically related disciplines investigate evidence, make recommendations, and take action to advance gender equity. Evidence on women’s advancement and leadership in the context of the European Alliance of Associations for Rheumatology, EULAR, is limited [1]. Objectives: The objective of the EULAR Task Force on Gender Equity in Academic Rheumatology was to establish the extent of the unmet need for support of female rheumatologists, health professionals and non-clinical scientists in academic rheumatology and develop a framework to address this through EULAR and Emerging EULAR Network (EMEUNET). Methods: Potential interventions to accelerate gender-equitable career advancement in academic rheumatology were gathered from a narrative review of the relevant literature, expert opinion of a multi-disciplinary Task Force (comprised of 23 members from 11 countries), data from the surveys of EULAR scientific member society leaders, EULAR and EMEUNET members, and EULAR Executive Committee members. These interventions were rated by Task Force members, who ranked each according to perceived priority on a five-point numeric scale from 1 = very low to 5 = very high. Results: A framework of 29 potential interventions was formulated, which covers six thematic areas, namely, EULAR policies, advocacy and communication, EULAR Congress and associated symposia, training courses, mentoring/peer support, and EULAR funding (Figure 1). Figure 1. A framework of potential interventions with the levels of priority, mean and standard deviation (SD) Conclusion: The framework provides structured interventions for accelerating gender-equitable career advancement in academic rheumatology. References: [1]Andreoli L, Ovseiko PV, Hassan N, et al. Gender equity in clinical practice, research and training: Where do we stand in rheumatology? Joint Bone Spine 2019;86(6):669-72. Acknowledgements: The task force is grateful to EULAR for funding this activity under project number EPI 024. Disclosure of Interests: None declared
AB0770 A RARE CASE OF SYNOVIAL METASTASIS REVEALED BY KNEE PAIN
Authors: M. Yasmine, S. Miladi, A. Fazaa, S. Mariem, K. Ouenniche, L. Souebni, S. Kassab, S. Chekili, K. Ben Abdelghani, A. Laatar
Journal: Annals of the Rheumatic Diseases (2021)

Background: Intra-articular masses are not frequently encountered in clinical practice. However, the differential diagnosis can be broad. Synovial metastasis is a rare presentation that carries a poor prognosis with a poor survival rate. Objectives: Here by a case of synovial metastasis of the knee joint in a patient diagnosed with an adenocarcinoma of the lung. Methods: A 60-year-old man with no remarkable past medical history presented to our department of rheumatology with right knee pain. He described a dull ache and swelling in his right knee with a dragging sensation, waking him up at night on a regular basis. The symptoms lasted from 6 months and were partially improved by analgesics and anti-inflammatory drugs. On examination, temperature was normal. The knee was edematous, erythematous, and warm with a range of motion of &lt;90°. Laboratory investigations showed high acute phase reactants, the erythrocyte sedimentation rate was 75 mm. A plain radiograph of the left knee demonstrated a lytic lesion of the upper tibia. A magnetic resonance imaging of the right knee showed diffuse enlargement of the joint space due to a tissue infiltration within the synovium. These structures demonstrated heterogeneously increased T2 signal and intermediate T1 intensity characteristics. Most of the joint space was replaced by hyper enhancing synovium. At that time, differential considerations included severe inflammatory arthritis and synovial chondromatosis rather than unusual metastasis. Results: Biopsy concluded to synovial metastasis from primary adenocarcinoma. Further investigations were necessary. Chest tomography showed a tumor process of left lower lobe associated with mediastinal lymphadenopathy. The patient was treated with palliative external radiotherapy to the right knee. The evolution was marked by the appearance of multiple tracheobronchial fistulas . The patient died 3 months later due to the progression of the disease. Conclusion: We report a rare case of synovial metastasis concomitant to a lung adenocarcinoma. It is important to make a rapid diagnosis as early recognition of malignant infiltration into joints ensure appropriate multidisciplinary management decisions. Disclosure of Interests: None declared
POS0016 THE EVALUATION OF FUNCTIONAL ABILITIES OF PATIENTS WITH OSTEOPOROTIC VERTEBRAL FRACTURES AS A BASIS FOR REHABILITATION PROGRAMS DEVELOPING
Authors: L. Marchenkova, V. Vasileva, M. Eryomushkin
Journal: Annals of the Rheumatic Diseases (2021)

Background: Due to the demand for special rehabilitation programs for patients with osteoporotic vertebral fractures (VFs), it is of interest to study the functional abilities of those patients. The scientific hypothesis suggests that osteoporotic VFs would cause muscle weakness, muscle dysfunction and conditional disturbances. Objectives: to estimate muscle strength, motor function and coordination disorders in patients with VFs in the setting of systemic osteoporosis as a basis for rehabilitation programs developing. Methods: 120 patients aged 43−80 with primary osteoporosis were enrolled. Study group comprised of 60 subjects (56 women, 4 men) with at least 1 VF confirmed by X-rays. Control group included 60 subjects (56 women, 4 men) with osteoporosis but without any osteoporotic fracture. The examination program included back muscles tenzodynamometry, balance tests and stabilometry. Results: Muscle strength deficiency was estimated in study group in trunk flexors (TF) — 40.9% and in trunk extensors (TE) — 18.1% with an adequate function of the left lateral flexors (LLF) and in right lateral flexors (RLF). Patients with VFs had the lower muscle strength vs controls of TE (15.64±9.8 vs 27.73±9.9 kg, p=0.00002), TF (14.61±8.98 vs 21.28±8.38 kg, p=0.0006), LLF (13.10±7.2 vs 24.06±8.9 kg, p=0.005) and RLF 13.44±7.43 vs 24.26±7.65 kg, p=0.0003). Patients with VFs lose their balance faster during one-leg-standing test with open eyes (5.0 [1.0; 10.0] vs 7.5 [5.0; 10.5] sec in control group, p=0.03) and with closed eyes (2.0 [0; 3.0] vs 3.5 [3.0; 5.0] sec, p=0.04). Fukuda-Unterberger test showed greater side dislocation in study group — 40° [25; 45] vs controls 30° [10; 45], (p=0.02). According to stabilometry study group was characterized vs control group by lower balance coefficient with open eyes (77.2±7.6 vs 85.7±9.4%, p=0.002) and with closed eyes (67.1±9.8 vs 73.4±9.9%, p=0.03), greater sagittal displacement (6.8 [2.1; 37.7] vs 4.8 [1.8; 10.7] mm, p=0.025) and deviation in the saggital plane (1.2 [-1.07; 1.5] vs -1.2 [-1.5; 1.2] mm, p=0.01), and also less pressure center velocity (9.51±4.4 vs 7.1±2.7 mm/sec, р=0.009). Conclusion: Osteoporotic VFs are associated with reduction of trunk muscles strength and negatively affect static and dynamic balance function that should be taken into account when developing rehabilitation programs for these patients. Disclosure of Interests: None declared.
POS0791 DOSE-DEPENDENT RELATIONSHIP BETWEEN HISTORY OF DENTAL CARIES AND INCREASED RISK OF NEWLY-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS: A NATIONWIDE POPULATION-BASED COHORT STUDY
Authors: K. S. K. Ma
Journal: Annals of the Rheumatic Diseases (2021)

Background: The relationship between oral bacterial invasion caused by periodontal pathogens and risk of systemic lupus erythematosus (SLE) has been identified. However, there is a lack of knowledge on the relationship between carious lesions and risk of SLE, as well as longitudinal studies on the effect of restorative materials on SLE. Objectives: This study investigated whether patients with history of dental caries are associated with an increased risk of newly-onset systemic lupus erythematosus (SLE). Methods: A total of 541,461 carious patients and 258,918 controls without carious teeth were enrolled between 1997 and 2013 from the National Health Insurance Research Database. Subgroup analyses were conducted based on restorative materials included amalgam, resins or both. Cumulative incidences and hazard ratios (HRs) of developing SLE were derived after adjusting for age, gender, comorbidities and co-medications in a multivariable model. Results: The risk of SLE was significantly higher in carious patients (HR = 1.984, 95% = 1.652-2.382) compared to controls. Dose-dependent relationship between caries and risk of SLE was identified. The risks of SLE were higher among those who had over 11 dental visits (HR = 2.525, 95% C.I = 1.859-3.429), followed by those with 3-10 dental visits (HR = 1.863, 95% C.I= 1.356-2.543), then those with 1-2 visits, and were higher among those who had over 5 carious teeth extractions (HR = 1.877, 95% C.I= 1.186-2.970), followed by those with 1-4 carious teeth extractions (HR = 1.363, 95% CI = 1.167-1.593), then those without extraction. The risk of SLE among different restorative materials, including amalgam or resins, for caries management, were not significantly different. Conclusion: Patients with caries were associated with higher SLE risks. The relationship between caries and risk of SLE was dose-dependent, regardless of used restorative materials. Disclosure of Interests: None declared
Covid-19: Official figures “underestimate” deaths caused by discharging patients into care homes
Authors: Adrian O’Dowd
Journal: BMJ (2021)

Covid-19: Official figures "underestimate" deaths caused by discharging patients into care homes Adrian O'DowdThe UK government has admitted that its policy during the early stages of the covid-19 pandemic to have patients moved from hospitals to care homes may have directly led to subsequent deaths.
NIR‐Responsive Ti<sub>3</sub>C<sub>2</sub> MXene Colloidal Solution for Curing Purulent Subcutaneous Infection through the “Nanothermal Blade” Effect
Authors: Xiaolan Wang, Mengyu Yao, Limin Ma, Peng Yu, Teliang Lu, Luhui Zhang, Xinyuan Yuan, Yu Zhang, Jiandong Ye
Journal: Advanced Healthcare Materials (2021)

Abstract Pathogenic microorganisms’ infections have always been a difficult clinical challenge and lead to serious health problems. Thus, a new strategy is urgently needed. In this study, a simple preparation method for Ti 3 C 2 MXene colloidal solution is proposed. In vitro, Staphylococcus aureus is treated with 250 µg mL −1 of Ti 3 C 2 colloidal solution under 5 min of 808 nm near‐infrared (NIR) laser irradiation twice. Staphylococcus aureus is eliminated by the “nanothermal blade” effect from Ti 3 C 2 combined with NIR; the antibacterial rate is 99%, which is higher than the antibacterial rate of pure Ti 3 C 2 alone 78%. The antibacterial mechanism underlying this treatment may be that the thermal Ti 3 C 2 nanosheets first transfer heat to the cell membrane, disrupting the membrane structure, disturbing the metabolism and causing leakage of bacterial protein and deoxyribonucleic acid, consequently leading to bacterial death. In vivo results indicate that Ti 3 C 2 colloidal solution under NIR can effectively kill Staphylococcus aureus and prevent inflammation. Moreover, 250 µg mL −1 Ti 3 C 2 colloidal solution is nontoxic to mouse organs during the therapeutic process. Therefore, Ti 3 C 2 colloidal solution can be an ideal candidate for subcutaneous infection application. The antibacterial mechanism proposed in this study aids the investigation of other MXenes as antibacterial agents.
AB0211 SWITCHING FROM ETANERCEPT ORIGINAL TO ETANERCEPT BIOSIMILAR: LONG TERM FOLLOW UP
Authors: G. Sada, M. C. Laíño Piñeiro, V. Aldasoro, J. Mendizabal, M. Lopez, S. Garcia Perez, L. Garrido Courel, N. Del-Val, L. Horcada, R. Gutiérrez Polo, I. Paniagua Zudaire, C. Fito-Manteca
Journal: Annals of the Rheumatic Diseases (2021)

Background: Biosimilar drugs has supposed a huge savings in our health systems and there are data that conclude that they work as original molecules when we making these switchings. There are limited studies that analize these patients across the time (1-3). Objectives: Long term follow up of patients after switching from original etanercept to biosimilar drug. Methods: We reviewed 187 patients who started Etanercept original in Rheumatology department at Navarra Hospital Complex and their switch to Etanercept biosimilar with a follow-up of 18 months. Results: The switch was performed in 176 patients with rheumatoid arthritis (RA), spondyloarthritis (SpA) and psoriatic arthritis (PsA). At 18 months of follow-up 26,1% discontinued treatment; 13% at 6 months, 9,1% at 12 months and 4% patients at 18 months. The median time in etanercept original drug before switching was 52 months. There were 46 withdrawal patients with etanercept biosimilar: 34 inefficacy, 3 skin reaction, 2 malignancies (lymphoma and GIST), 1 injection site reaction, 1 headache, 1 diarrhea, 1 recurrent urinary infection, 1 heart failure and 2 deaths. 25 patients returned to Etanercept original but 3 did not achieve good response; all of them in RA group. Conclusion: In our series 50 % of withdrawal happened at 6 months of follow-up. 73,9% had a good response with etanercept biosimilar at 18 months. The main reason to stop biosimilar drug was inefficacy. Longer-term follow-up and greater number of patients are necessary to ratify these data. References: [1]Selmi C, et al. BENEFIT: real-world effectiveness of SB4 after transition from reference etanercept in rheumatoid arthritis and axial spondyloarthritis. Clin Exp Rheumatol. 2020 Jun 30. Epub ahead of print. [2]Glintborg B, et al. To switch or not to switch: results of a nationwide guideline of mandatory switching from originator to biosimilar etanercept. One-year treatment outcomes in 2061 patients with inflammatory arthritis from the DANBIO registry. Ann Rheum Dis. 2019 Feb;78(2):192-200. [3]Tweehuysen L, et al. Open-Label, Non-Mandatory Transitioning From Originator Etanercept to Biosimilar SB4: Six-Month Results From a Controlled Cohort Study. Arthritis Rheumatol. 2018 Sep;70(9):1408-1418. Table 1. WITHDRAWAL (months) BACK TO ENBREL (n) CONTINUEENBREL (n) TIME TO SWITCH (months) REASON FOR WITHDRAWAL Inefficacy A.event* Cancer Death RA 22 11 8 53 14 5 2 1 PsA 16 6 6 53,5 15 0 0 1 SpA 8 8 8 45 5 3 0 0 TOTAL 46 25 22 52 34 8 2 2 *Infections (1), Heart failure (1), skin reaction (3), injection point reaction (1) RA: rheumatoid arthritis; PsA: psoriatic artrhritis; SpA: spondyloarthritis Disclosure of Interests: None declared
Joint tenderness and ultrasound inflammation in DMARD-naïve patients with early rheumatoid arthritis
Authors: Nina Paulshus Sundlisater, Anna-Birgitte Aga, Inge Christoffer Olsen, Hilde Berner Hammer, Till Uhlig, Désirée van der Heijde, Tore K Kvien, Espen A Haavardsholm, Siri Lillegraven
Journal: Annals of the Rheumatic Diseases (2021)

Tender joint count is part of most composite disease activity scores and treatment targets in rheumatoid arthritis (RA).1 Joint tenderness could represent not only synovial inflammation in the absence of clinical swelling but also factors such as erosive damage and pain sensitisation.2 Ultrasound examination can add information to the clinical evaluation of inflammation.

Joint tenderness did not reflect inflammatory activity when assessed by ultrasound in patients with established RA3 but might be more related to inflammation in early arthritis.4 5 We aimed to explore joint tenderness in DMARD-naive patients with early RA and assess whether this finding was associated with ultrasound inflammation in the absence of swelling.

The analyses were performed using baseline data from the ARCTIC trial,6 which included assessment of joint tenderness by Ritchie Articular Index and a 44-swollen joint count. The Ritchie Articular Index grades joint tenderness 0–3, with certain joints being treated as a single unit, for example, the metacarpal-phalangeal (MCP) joints. In the ultrasound examination, 32 joints were all dorsally scored semiquantitatively 0–3 for power Doppler (PD), with an ultrasound atlas for reference.6 The wrists were predefined as the joint area of interest since they are commonly involved in RA and were assessed both clinically and by ultrasound. Additionally, in these joints, scoring of tenderness by Ritchie Articular Index could correspond to the more commonly used tender joint count. The presence of ultrasound inflammation was defined as …