tbuckley/cabot-search huggingface dataset:
AB0194 Uses of magnetic resonance imaging (mri) and myelography in iraqi patients with prolapsed intervertebral disc (pid) and the correlation of joint mibility to pid
Authors: ZS Al-Rawi, SH Al-Amiedy, A Kammona
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> <h3>Objectives</h3> To compare between the uses and side effects of MRI and myelography for the diagnosis of PID, and to assess the relation between PID and joint mobility. <h3>Methods</h3> One hundred thirty patients with PID proved by MRI (65) on myelography (65) were compared with that in an age and sex matched healthy 130 individuals without PID joint mobility was scored on a scale of 0–8 using the method described by Reighton <i>et al</i>. <h3>Results</h3> PID was commonly reported at L4/5 or L5/S1 levels, whilst other levels were less frequently involved. Both imaging modalities were highly sensitive to prove the diagnosis of PID and its level, unfortunately myelography showed significantly more side effects compared to MRI. The number of patients with hypermobile joints and the total mobility scores were comparable in patients and control groups. <h3>Conclusion</h3> This study showed that both imaging modalities are sensitive for diagnosis of PID, and MRI is a safer technique compared to myelography. There is no relation between PID and joint mobility.
A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density
Authors: Nasa Sinnott-Armstrong, Isabel S. Sousa, Samantha Laber, Elizabeth Rendina-Ruedy, Simon E. Nitter Dankel, Teresa Ferreira, Gunnar Mellgren, David Karasik, Manuel Rivas, Jonathan Pritchard, Anyonya R. Guntur, Roger D. Cox, Cecilia M. Lindgren, Hans Hauner, Richard Sallari, Clifford J. Rosen, Yi-Hsiang Hsu, Eric S. Lander, Douglas P. Kiel, Melina Claussnitzer
Journal: Cell Metabolism (2021)

Skeletal and glycemic traits have shared etiology, but the underlying genetic factors remain largely unknown. To identify genetic loci that may have pleiotropic effects, we studied Genome-wide association studies (GWASs) for bone mineral density and glycemic traits and identified a bivariate risk locus at 3q21. Using sequence and epigenetic modeling, we prioritized an adenylate cyclase 5 (ADCY5) intronic causal variant, rs56371916. This SNP changes the binding affinity of SREBP1 and leads to differential ADCY5 gene expression, altering the chromatin landscape from poised to repressed. These alterations result in bone- and type 2 diabetes-relevant cell-autonomous changes in lipid metabolism in osteoblasts and adipocytes. We validated our findings by directly manipulating the regulator SREBP1, the target gene ADCY5, and the variant rs56371916, which together imply a novel link between fatty acid oxidation and osteoblast differentiation. Our work, by systematic functional dissection of pleiotropic GWAS loci, represents a framework to uncover biological mechanisms affecting pleiotropic traits.
Abstract 18484: An App-based Discrete Choice Survey Tool for Assessing Patient Treatment Preferences in Critical Limb Ischemia
Authors: Matthew A Corriere, Ryan T Barnard, Santiago Saldana, Derrick S Boone, Douglas Easterlin g, Adam Hyde, Gregory L Burke, Raul J Guzman, Yazan Duwayri, Edward ip
Journal: Circulation (2015)

Introduction: Patient centered care has potential to improve PAD treatment but providers need structured approaches to understand patients' values and apply them to individualized treatment. We used focus groups to identify factors patients with critical limb ischemia (CLI) consider important for treatment choices and developed an app to assess their treatment preferences during clinical encounters. Methods: Focus groups were used to identify factors patients with CLI consider important and relevant for treatment decisions. Treatment attributes and levels derived from qualitative data were then used to design an app for assessing treatment preferences through a discrete choice survey. Treatment options were presented pair-wise in patients' own terms using an orthogonal array design, and choice set order was individually randomized. The app also collected demographic and educational information, vascular specific health related quality of life, and user satisfaction. Aggregate responses were evaluated using conjoint analysis, and relative attribute importance was defined based on a ratio-based share of overall utility. Results: 26 patients with CLI participated in focus groups used to identify important attributes, levels, and terminology. A patient friendly app was developed and subsequently pilot tested in 20 additional patients. Mean participant age was 63.4 ± 11.2 years; 25% were women, 30% were African American, and 40% had a college education. Mean app completion time was 20.4 ± 6.6 minutes. Aggregate attribute importances in decreasing utility order were: type of treatment (45.9), chance of successful treatment outcome (22.9), treatment risk (15.8), symptomatic response (13.5), and treatment durability (1.9). 90% of participants indicated that they believed the app will help patients contribute to better treatment choices, and 90% believed it would help providers understand what patients consider most important. Conclusion: CLI treatment preference assessment is feasible during clinical encounters and may facilitate patient contributions to choices. Structured decision tools have potential to increase patient engagement and improve both satisfaction and outcomes.
SAT0209 Mri evaluation of chondral lesions in knee osteoarthritis: arthroscopic correlation
Authors: C Acebes, A Robledo, J Granizo, G Herrero-Beaumont
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> Arthroscopic exam evaluation (chondroscopy) of the articular cartilage is considered a relevant instrument of OA outcome for research purposes. Nevertheless availablity of other accurate but non-invasive methods for chondral evaluation in OA, such us MRI, should be desireble. <h3>Objectives</h3> To evaluate the capacity of MRI to score chondropathy in knee OA compared with chondroscopy. <h3>Methods</h3> 24 consecutive patients diagnosed of knee OA were referred for knee hyaline cartilage MR imaging of medial chondile and tibial plateau with a fat-suppressed spoiled gradient-echo sequences (SPGR) before chondroscopy. MRI and chondroscopic cartilage lesions evaluated by two methods were registered in an scale diagram and total score chondropathy was calculated using a software programme (Autocad). Correlation was determined by Sperman´s test for both evaluation (p &lt; 0,05). <h3>Results</h3> High and significant intraobserver correlation was observed for evaluation of medial chondile and tibial plateau by chondroscopy r = 0,806 and r = 0,721 and by MRI r = 0,805 and r = 0,680 respectively. Correlation coefficient between chondroscopic and MRI score for chondile and tibia was r = 0,781 and r = 0,531 respectively. <h3>Conclusion</h3> Fat-suppressed SPGR imaging seems to be a relevant tool for evaluation of cartilage lesions in OA of the knee showing a high correlation between both procedures. Both chondroscopy and MRI have a lower correlation for the detection of chondral lesions in tibial plateau than in femoral chondile. Supp. by a grant of Health Research Funding (98/626).
Postinfectious Epigenetic Immune Modifications — A Double-Edged Sword
Authors: Andrew R. DiNardo, Mihai G. Netea, Daniel M. Musher
Journal: New England Journal of Medicine (2021)

Antigen-nonspecific host defenses are altered by infections, with epigenetic changes in the effector cells of natural immunity. Some of these changes enhance immune responses, and some interfere with them. The success of certain vaccination approaches may depend on finding a way to reverse the detrimental epigenetic effects of previous infection.
Extracellular vesicles deposit <i>PCNA</i> to rejuvenate aged bone marrow–derived mesenchymal stem cells and slow age-related degeneration
Authors: Qian Lei, Fei Gao, Teng Liu, Wenxiang Ren, Li Chen, Yulin Cao, Wenlan Chen, Shaojun Guo, Qiong Zhang, Weiqun Chen, Hongxiang Wang, Zhichao Chen, Qiubai Li, Yu Hu, An-Yuan Guo
Journal: Science Translational Medicine (2021)

Umbilical cord MSC–derived extracellular vesicles rejuvenate aged bone marrow MSCs and slow age-related degeneration in mice.
Bioinspired Materials: A Bioinspired, Sustained‐Release Material in Response to Internal Signals for Biphasic Chemical Sensing in Wound Therapy (Adv. Healthcare Mater. 2/2021)
Authors: Wing‐Fu Lai, Ryan Deng, Tingchao He, Wing‐Tak Wong
Journal: Advanced Healthcare Materials (2021)

In article number 2001267, Wing-Fu Lai and co-workers develop a bioinspired and luminescent material which can respond to internal signals to enable biphasic monitoring of the drug delivery process. Together with its ease of fabrication, high biocompatibility, high drug loading efficiency, and high release sustainability, this material shows high potential to be developed into an intelligent solid-state device for wound treatment in the future.
Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome
Authors: Malte Christoph Rühlemann, Britt Marie Hermes, Corinna Bang, Shauni Doms, Lucas Moitinho-Silva, Louise Bruun Thingholm, Fabian Frost, Frauke Degenhardt, Michael Wittig, Jan Kässens, Frank Ulrich Weiss, Annette Peters, Klaus Neuhaus, Uwe Völker, Henry Völzke, Georg Homuth, Stefan Weiss, Harald Grallert, Matthias Laudes, Wolfgang Lieb, Dirk Haller, Markus M. Lerch, John F. Baines, Andre Franke
Journal: Nature Genetics (2021)
THU0490 DEEP FRICTION MASSAGE VERSUS LOCAL STEROID INJECTION FOR TREATMENT OF PLANTAR FASCIITIS: A RANDOMIZED CONTROLLED TRIAL
Authors: A. Moshrif, M. Elwan, U. Daifallah
Journal: Annals of the Rheumatic Diseases (2020)

Background: Deep friction massage (DFM) has long been proven to be effective in the treatment of some tendinopathies. Objectives: to evaluate the efficacy of DFM in the treatment of plantar fasciitis (PF) in comparison with local steroid injection. Methods: In this randomized controlled trial, 60 patients with PF were selected from those attending the rheumatology and rehabilitation outpatient clinic and then randomized to receive either 40 mg triamcinolone local injection (group I: 30 patients; 41 heals) using the medial approach or to receive seven sessions of deep transverse friction massage (10 min each) every other day (group II: 30 patients; 36 heels). The outcome measures were the pain and function assessment by visual analog scale and foot function index, respectively, at 2 and 6 weeks of follow-up. Results: Demographic data showed a statistically insignificant difference in age, female to male ratio, and BMI in both groups. The mean age was 39.42 years in group I and 41.32 years in group II (P=0.86). The female to male ratio was 3: 1 in group I and 2.75: 1 in group II, and the mean BMI was 32.41 in group I and 33.31 in group II (P=0.51). At 2 and 6 weeks of follow-up, DFM led to less improvement in pain and function compared with local steroid injection (P=0.001 and 0.002, respectively, at both time points of follow-up). Conclusion: This study revealed that DFM is not effective as a single modality in treatment of PF. Further large-scale studies are needed to support this observation. Disclosure of Interests: : None declared
THU0015 Na+, k+, atpase, intercellular adhesion molecule-1 and rheumatoid arthritis: a study on the erythrocyte membrane
Authors: A Kiziltunc, S Cogalgil, M Ugur
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> <h3>Objectives</h3> We measured serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and erythrocyte membrane Na+, K+, ATPase activity and the correlation of these parameters in patients with rheumatoid arthritis (RA), and investigated whether the levels of sICAM-1 were correlated with the disease activity. <h3>Methods</h3> Serum sICAM-1 levels were determined with sandwich enzyme-linked immunosorbent assay (ELISA) and erythrocyte membrane Na+, K+, ATPase activity with spectrophotometric method in sera from 42 patients with RA and in 30 healthy controls. Eryhtrocyte sedimentation rate (ESR) was determined according to the Westergren method and C-reactive protein (CRP) by nephelometric method. Disease activity was assessed by disease activity criterias. <h3>Results</h3> Although decreased erythrocyte membrane Na+, K+, ATPase activity, serum levels of sICAM-1 were significantly higher in patients with RA than in healthy controls. Significant negative correlations between sICAM-1 levels and erythrocyte membrane Na+, K+, ATPase activity (r = -0.678, p &lt; 0.001) were observed. There was a weak but statistically significant positive correlation between sICAM-1 levels with Ritchie articular index (RAI) score and CRP (r = 0.32, p &lt; 0.05; r = 0.44, p &lt; 0.01, respectively), whereas no significant correlation was observed between sICAM-1 levels with ESR, age and disease duration. There was no correlation between values of CRP, RAI and ESR with erythrocyte membrane Na+, K+, ATPase activity. <h3>Conclusion</h3> From these data, it is concluded that the decreases in erythrocyte membrane Na+, K+, ATPase activity and increases in sICAM-1, ESR and CRP levels are present in RA, and that the decrease in erythrocyte membrane Na+, K+, ATPase activity in RA might be due to increased sICAM-1, and increased levels of sICAM-1 and correlations with other parameters may be a significant and novel marker for evaluating the disease status and the activity of RA.
Revised UNAIDS/WHO Ethical Guidance for HIV Prevention Trials
Authors: Rieke van der Graaf, Andreas Reis, Peter Godfrey-Faussett
Journal: JAMA (2021)

Michael S. Saag, MD; Rajesh T. Gandhi, MD; Jennifer F. Hoy, MBBS; Raphael J. Landovitz, MD; Melanie A. Thompson, MD; Paul E. Sax, MD; Davey M. Smith, MD; Constance A. Benson, MD; Susan P. Buchbinder, MD; Carlos del Rio, MD; Joseph J. Eron Jr, MD; Gerd Fätkenheuer, MD; Huldrych F. Günthard, MD; Jean-Michel Molina, MD; Donna M. Jacobsen, BS; Paul A. Volberding, MD
LRPAP1 autoantibodies in mantle cell lymphoma are associated with superior outcome
Authors: Lorenz Thurner, Natalie Fadle, Jörg Thomas Bittenbring, Evi Regitz, Rita Schuck, Onur Cetin, Ariane Stuhr, Torben Rixecker, Niels Murawski, Viola Poeschel, Dominic Kaddu-Mulindwa, Klaus-Dieter Preuss, Stephan Stilgenbauer, Olivier Hermine, Hanneke C. Kluin-Nelemans, Sylvia Hartmann, Martin Dreyling, Christiane Pott, Moritz Bewarder, Eva Hoster
Journal: Blood (2021)
SAT0136 Chest expansion and spirometric measures in patients with primary fibromyalgia
Authors: S Ozgocmen, O Bolgen Cimen, O Ardicoglu
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> Despite normal spirometric values patients with fibromyalgia had lower values of maximum inspiratory (MIP) and expiratory pressures (MEP) than matched healthy controls. Values of MIP and MEP reflect respiratory muscle strength, therefore low values have been explained by respiratory muscle weakness or dysfunction. <h3>Objectives</h3> This study proposed to assess the relationship of chest expansion with maximal inspiratory (MIP) and expiratory pressures (MEP) in primary fibromyalgia (FM) syndrome. <h3>Methods</h3> Thirty female patients, aged 22–52, who met the 1990 ACR [1] criteria for the classification of FM were examined and compared with 29 healthy, age and BMI matched female subjects (aged 24–50). Pulmonary function tests were assessed by a computerised spirometer. The maximum respiratory pressures were carried out by using a digital mouth-pressuremeter. Chest expansion measurements, spirometric values, MIP and MEP values of patients with primary FM have been compared with controls. <h3>Results</h3> Patients with FM had lower chest expansion, MEP and MIP values with respect to the controls. Chest expansion correlated significantly with MIP and MEP values. There was no significant difference among groups in spirometric values. <h3>Conclusion</h3> Our results indicate that patients with FM have impaired respiratory muscle strength and measurement of chest expansion may be an appropriate and practical method for evaluating respiratory muscle strength in patients with FM.
Modern Trends in Radiotherapy 1.
Journal: Annals of Internal Medicine (1968)

Radiotherapy is a dynamically developing field of cancer treatment. Advances in radiotherapy are significantly related to new knowledge in radiobiology, the introduction of new systems in radiodiagnostics and radiation therapy planning. The technical development of irradiation systems over the last 10 years has greatly improved the quality of radiation therapy. The constant aim of modern radiation therapy is to minimize the toxicity of radiotherapy while maintaining the therapeutic effect. With the development of radiotherapy, however, the issue of so-called financial toxicity of various radiation techniques and disproportionate increase in treatment spending, regardless of cost-effectiveness.
Parenteral iron therapy and phosphorus homeostasis: A review
Authors: Kamyar Kalantar‐Zadeh, Tomas Ganz, Henry Trumbo, Melvin H. Seid, Lawrence T. Goodnough, Michael A. Levine
Journal: American Journal of Hematology (2021)

Phosphorus has an essential role in cellular and extracellular metabolism; maintenance of normal phosphorus homeostasis is critical. Phosphorus homeostasis can be affected by diet and certain medications; some intravenous iron formulations can induce renal phosphate excretion and hypophosphatemia, likely through increasing serum concentrations of intact fibroblast growth factor 23. Case studies provide insights into two types of hypophosphatemia: acute symptomatic and chronic hypophosphatemia, while considering the role of pre-existing conditions and comorbidities, medications, and intravenous iron. This review examines phosphorus homeostasis and hypophosphatemia, with emphasis on effects of iron deficiency and iron replacement using intravenous iron formulations.
Renal AAV2-Mediated Overexpression of Long Non-Coding RNA H19 Attenuates Ischemic Acute Kidney Injury Through Sponging of microRNA-30a-5p
Authors: George Haddad, Malte Kölling, Urs A. Wegmann, Angela Dettling, Harald Seeger, Roland Schmitt, Inga Soerensen-Zender, Hermann Haller, Andreas D. Kistler, Anne Dueck, Stefan Engelhardt, Thomas Thum, Thomas F. Mueller, Rudolf P. Wüthrich, Johan M. Lorenzen
Journal: Journal of the American Society of Nephrology (2021)

Renal ischemia-reperfusion (I/R) injury is a major cause of AKI. Noncoding RNAs are intricately involved in the pathophysiology of this form of AKI. Transcription of hypoxia-induced, long noncoding RNA H19, which shows high embryonic expression and is silenced in adults, is upregulated in renal I/R injury.Lentivirus-mediated overexpression, as well as antisense oligonucleotide-based silencing, modulated H19 in vitro. In vivo analyses used constitutive H19 knockout mice. In addition, renal vein injection of adeno-associated virus 2 (AAV2) carrying H19 caused overexpression in the kidney. Expression of H19 in kidney transplant patients with I/R injury was investigated.H19 is upregulated in kidney biopsies of patients with AKI, in murine ischemic kidney tissue, and in cultured and ex vivo sorted hypoxic endothelial cells (ECs) and tubular epithelial cells (TECs). Transcription factors hypoxia-inducible factor 1-α, LHX8, and SPI1 activate H19 in ECs and TECs. H19 overexpression promotes angiogenesis in vitro and in vivo. In vivo, transient AAV2-mediated H19 overexpression significantly improved kidney function, reduced apoptosis, and reduced inflammation, as well as preserving capillary density and tubular epithelial integrity. Sponging of miR-30a-5p mediated the effects, which, in turn, led to target regulation of Dll4, ATG5, and Snai1.H19 overexpression confers protection against renal injury by stimulating proangiogenic signaling. H19 overexpression may be a promising future therapeutic option in the treatment of patients with ischemic AKI.
Hemangioblastoma
Authors: Nicolas Gohimont, Patrice Jissendi Tchofo, Marie-Lucie Racu, Kim Entezari, Isabelle Salmon, Marianne Tondeur, Diana Ene
Journal: Clinical Nuclear Medicine (2021)

Abstract Hemangioblastoma (HB) is the most common primary intra-axial posterior fossa tumor in adults and is a benign vascular neoplasm. We report the case of a 73-year-old man suffering from biochemical recurrence of prostate cancer where intense overexpression of prostate-specific membrane antigen (PSMA) was observed in HB in a PSMA PET/CT. Overexpression of PSMA in tumor-associated vascular structures has been proposed as an explanation of PSMA ligand uptake in several nonprostatic tumors. Given the pathological nature of HB, this mechanism may explain the intense overexpression of PSMA observed in present case.
Meal Size, Not Body Size, Explains Errors in Estimating the Calorie Content of Meals
Authors: Brian Wansink, Pierre Chandon
Journal: Annals of Internal Medicine (2006)

This article has been retracted. See Notice of Retraction. Background: Although most people underestimate the calories they consume during a meal or during the day, calorie underestimation is especially extreme among overweight persons. The reason for this systematic bias is unknown. Objective: To investigate whether the association between calorie underestimation and body mass reflects a tendency for all persons to underestimate calories as the size of a meal increases. Design: Overweight and normal-weight adults estimated the number of calories of a fast-food meal they had ordered and eaten (study 1) or of 15 fast-food meals that were chosen by the experimenter (study 2) in a randomized, controlled trial. Their estimations were compared with the actual number of calories of the meals. Setting: Study 1 was a field study conducted in fast-food restaurants in 3 medium-sized midwestern U.S. cities. Study 2 was conducted in a laboratory at a major U.S. research university. Participants: Study 1 involved 105 lunchtime diners (average body mass index [BMI], 24.2 kg/m2 [range, 17.2 to 33.5 kg/m2]). Study 2 involved 40 undergraduate students (average BMI, 23.2 kg/m2 [range, 16.1 to 32.3 kg/m2]). Measurements: Participants were asked to estimate the number of calories in a fast-food meal they had ordered and eaten (study 1) or in 15 sizes of the same fast-food meal (study 2). The actual number of calories in the meals in the field study was obtained by unobtrusively recording the food that was ordered (identified from the wrappings and containers). Weight and height were self-reported. Results: Although participants strongly underestimated the number of calories in larger meals (by −38.0% in study 1 and by −22.6% in study 2), they almost perfectly estimated the number of calories in smaller meals (by −2.9% in study 1 and by 3.0% in study 2). After the authors controlled for body weight–related differences in meal size, the calorie estimations of normal-weight and overweight participants were identical in both studies. Limitations: These studies examined fast-food meals. Weight and height were self-reported. There were too few observations to distinguish between obese (BMI ≥30 kg/m2) and overweight (BMI >25 kg/m2 but <30 kg/m2) participants. Conclusions: Greater underestimation of calories by overweight persons is a consequence of their tendency to consume larger meals. Calorie underestimation is related to meal size, not body size.
Abstract 11655: Effect of Empagliflozin on Erythropoietin Levels and Red Blood Cell Morphology in Patients With Type 2 Diabetes and Coronary Artery Disease
Authors: David Mazer, Gregory M Hare, Philip W Connelly, Fei Zuo, Richard E Gilbert, Nadine Shehata, Adrian Quan, Hwee Teoh, Lawrence A Leiter, Bernard Zinman, Peter Juni, Kevin E Thorpe, Andrew T Yan, Kim A Connelly, Subodh Verma
Journal: Circulation (2019)

Introduction: Sodium-glucose cotransporter 2 (SGLT2) inhibitors have been shown to improve cardiovascular outcomes including hospitalization for heart failure, renal function and mortality. Previou...