tbuckley/cabot-search huggingface dataset:
The Cover
Authors: Thomas B. Cole
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mechanical Activation of Immune T Cells via a Water Driven Nanomotor
Authors: Dazhi Xie, Dongmei Fu, Shaoming Fu, Bin Chen, Weidong He, Daniela A. Wilson, Fei Peng
Journal: Advanced Healthcare Materials (2022)

As a key step during immune response, antigen recognition requires direct mechanical interaction between T cells and antigen presenting cells. Upon subjection to mechanical forces, mechanotransduction is triggered. In this study, the mechanical forces generated by water driven synthetic Au-Zn nanomotors are used to activate mechanosensitive Jurkat T cells. The triggering and activation of the cellular Ca2+ channel is observed. It is revealed that the mechanosensitive cells experience different degrees of activation upon receiving different mechanical input signals and demonstrate that external mechanical forces can optimize T cell activation. Compared with T cell activation with cytokines which can lead to the risky widespread activation of T cells and systemic immune storm, nanomotors can present mechanical force and achieve localized immune cell stimulation. It is expected that mechano nanomotors will contribute to the emerging T cell immunology field and facilitate more comprehensive understanding of the T cell mechanical response and function.
Bioinspired Multifunctional Black Phosphorus Hydrogel with Antibacterial and Antioxidant Properties: A Stepwise Countermeasure for Diabetic Skin Wound Healing
Authors: Qiuyue Ding, Tingfang Sun, Weijie Su, Xirui Jing, Bing Ye, Yanlin Su, Lian Zeng, Yanzhen Qu, Xu Yang, Yuzhou Wu, Zhiqiang Luo, Xiaodong Guo
Journal: Advanced Healthcare Materials (2022)

Abstract Cutaneous wound healing, especially diabetic wound healing, is a common clinical challenge. Reactive oxygen species (ROS) and bacterial infection are two major detrimental states that induce oxidative stress and inflammatory responses and impede angiogenesis and wound healing. A derivative of the metabolite itaconate, 4‐octyl itaconate (4OI) has attracted increasing research interest in recent years due to its antioxidant and anti‐inflammatory properties. In this study, 4OI‐modified black phosphorus (BP) nanosheets are incorporated into a photosensitive, multifunctional gelatin methacrylamide hydrogel to produce a new photothermal therapy (PTT) and photodynamic therapy (PDT) system with antibacterial and antioxidant properties for diabetic wound regeneration. Under laser irradiation, the 4OI–BP‐entrapped hydrogel enables rapid gelation, forming a membrane on wounds, and offers high PTT and PDT efficacy to eliminate bacterial infection. Without laser irradiation, BP acts as a carrier and controls the release of 4OI, with which it synergistically enhances antioxidant activity, thus alleviating excessive ROS damage to endothelial cells, promoting neovascularization, and facilitating faster diabetic wound closure. These findings indicate that 4OI–BP‐entrapped multifunctional hydrogel provides a stepwise countermeasure with antibacterial and antioxidant properties for enhanced diabetic wound healing and may lead to novel therapeutic interventions for diabetic ulcers.
MOTOR NOTES FOR MEDICAL MEN
Authors: H. M. Buist
Journal: BMJ (1919)

French Parliament, who h1as taken a great interest in the subjeot, was stationsd at Bu-Denib.M. Tuffier watched otie journey it made while lie was there.Tlle aeroplante started at 7 a.m., flew sixty-five kilomletres, over country occupied by dissidents, to au advanced post, slhipped two wounded men (one with a fracture of tlhe femur, and thje other with a serious fracture of the arm), and was back
Hypertonic Dehydration
Authors: I. W. MacPhee
Journal: BMJ (1955)

SARCOIDOSIS WITH CEREBRAL INVOLVEMENTB pleuritic pain in 1931 and over 20 years after the first proved evidence of sarcoidosis.One case is known to have survived over 40 years, but very few over 20 (Cowdell, 1954). SummaryThe case of a man with generalized sarcoidosis, personally observed for 20 years, is describei.First seen in 1934 on account of uveoparotid symptoms, which afterwards subsided gradually, he presented himself again in 1941, now with signs of cerebral tumour.Diagnosis of a slow-growing glioma was made by Pro- fessor Geoffrey Jefferson, who excised the left temporal lobe.After histological examination, the tumour was profiounced to be an intracerebral tuberculoma, but re- examination of the histological sections nine years later by Dr. J. S. Faulds led to recognition that the microscopical appearances were, in fact, typically sarcoid in character.The necropsy revealed that the sarcoid changes were limited to the brain, the thoracic lymph nodes, and the liver.The eyes could not be reported on.Proved cerebral sarcoidosis is a very rare condition, and a brief review of the literature is given.
MOTOR NOTES FOR MEDICAL MEN
Authors: H. M. Buist
Journal: BMJ (1922)

WrA13Ol 485 7"' -t ences are, of course, partly (due to differences in environ- mnent, but they must be partly innate, for they are observable in quite young children.It is difflcult to account for these phenomena unless we assume that impulses can in some way becorme surcharged with energy from the self- preservative and race-preservative centres, and that this energy will then expend itself on any object, however uupromising, if it cannot find au outlet through an cst4blished sentiment."Professor WEYGANDT's book on psychiatric diagnosis'0 is characterized by the variety and excellence of the photo- graphic pictures aud coloured plates of luLnatics of all sorts which it contains.The pictures are helped out by a clearly 'written and comprehensive text; full details of the methods of examination employed are given throughout: The volume may be recommended to the attention of alienists.The Mledical Register" for 1922 shows that the gradual inerease in the number of registered practitioners, which has been noted in previous years, is still maintained.The total niumnber on the Register at the end of 1921 was 45.408, as com- pared with 44,761 in 1920, and 44,510 in 1919.Of the total 49.52 per cent.were registered in England, 31.41 per cent. in Scotland, and 14.51 in Ireland; 4.34 per cent. of the names appear in the colonial list, and 0.22 per cent. in the foreign list.The Register contains for the first time the provisions of the new Dentists Act, 1921.The Dentists Register"12 for
Postpartum Hemorrhage
Authors: Jessica L. Bienstock, Ahizechukwu C. Eke, Nancy A. Hueppchen
Journal: New England Journal of Medicine (2021)

The major causes of postpartum hemorrhage are uterine atony, lacerations, retained placenta or clots, and clotting factor deficiency. Uterine massage, oxytocin, and methylergonovine are the main treatments, along with blood transfusion and cardiovascular support.
Curare
Authors: W. M. Maidlow
Journal: BMJ (1947)

in pressure was 2.3 cm. of water, while the rise in 26 normals was 6.7 cm. of water.The section dealing with the anatomical dissections is interest- ing and informative but, in a way, unsatisfactory.A consider- able amount of work has not been utilized to its full extent.Nerves are described as being " tightly stretched "-tension can be measured; " the clavicle moves from the rib "-distance and angles can be determined.Kelvin, throughout his life, stated a great though limited truth: " Science is measurement."There is no doubt that the rational assessment of anatomical problems is profoundly aided by the discerning analysis of even neces- sarily imperfect measurements.That this problem is not easy is appreciated, since we have been interested in its complexities and difficulties for some time.Telford and Mottershead have undoubtedly done a first-class piece of work, and this is properly acknowledged in your leading article, but their answers to some of the questions we pose would also be of great interest.-Weare, etc.,
Complications in Use of Temporary Intracranial Arterial Clip
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Тезисы научно-практической конференции с международным участием «VІІI научная сессия института гастроэнтерологии НАМН Украины. Новейшие технологии в теоретической и клинической гастроэнтерологии» (26-27 ноября 2020 года)
Authors: No Authors
Journal: GASTROENTEROLOGY (2020)

No abstract
ANAL FISSURE
Authors: W. B. Gabriel
Journal: BMJ (1939)

The successful management of a case of anal fissure depends so much on accurate diagnosis and on the ability to make a satisfactory examination that a few words must first be said on these important preliminaries.A fissure of the anus should be suspected whenever a patient complains of severe anal pain of a burning or cutting nature which is felt at or shortly after defaeca- tion and lasts for a variable time.The only other con- ditions which cause severe pain in this region are: (1) an acute tense anal haematoma, (2) an acute abscess, (3) the impaction of a piece of bone or other sharp foreign body in the anal canal within the grasp of the anal sphincters, (4) a carcinoma involving the anal canal and anal margin.According to the length of the history, some idea will be gained whether the condition is acute or chronic, but it is remarkable how often patients report a recent exacerba- tion of anal pain as if it were a new thing, whereas in reality they have suffered this at intervals for many months or years.Diagnosis The diagnosis of anal fissure is made in the first instance by inspection.Separation of the buttocks and anal margin permits the lower end of a fissure, or sometimes even its whole extent, to be seen.Situated posteriorly as a rule, and only rarely laterally and anteriorly, a fissure is often indicated by a slightly raised lip of skin at its lower border ; in chronic cases this becomes enlarged until it forms the "sentinel tag," a prominent bright-pink external tag of skin which is often flattened from side to side in a very characteristic way.The depth of a fissure can often be fairly well esti- mated by inspection: the shallow bright-red surface of a recent fissure is in marked contrast with a deep chronic fissure, the base of which often has an indolent greyish
Personal View
Authors: A. Prior
Journal: BMJ (1987)

A 34-year-old British woman who was told perfunctorily by her surgeon that she had to have a mastectomy describes her dismayed reaction, her search for other advice, and her subsequent choice of radiotherapy for treatment of her breast malignancy. Prior maintains that, unless there is a clear medical consensus that one form of treatment is superior to another in terms of survival, the patient must be given information on the alternatives and "must be able to participate in any decision on what is to be done with her body."
Halothane hepatitis.
Authors: S Sherlock
Journal: Gut (1971)

Progress report Halothane hepatitisSince its introduction in 1956, this anaesthetic has achieved wide popularity.It was therefore disappointing that in 1958 the first cases of hepatitis asso- ciated with it were observed, and by 1964 over 100 such instances had been published1.At first it was very difficult to decide whether the halothane was responsible or whether the patient was suffering from a coincidental virus hepatitis.Early retrospective trials gave conflicting results concerning the relationship between the hepatitis and the anaesthetic.Keeri-Szanto and Lafleur' from Montreal analysed 50,000 patient-anaesthetics, 35,000 of which were with halothane.They noted that from 1959 to 1962 there was an increase in postanaesthetic hepatic complications.They estimated that there was one death from liver necrosis for about every 8,000 'uneventful' anaes- thetics.Two comparatively large retrospective surveys, one conducted in Boston3 and the other in Cardiff4 failed to show any increased incidence of hepatic necrosis after the administration of halothane when compared with that following other anaesthetic agents.Prospective controlled trials have proved almost impossible and, in view of the difference of opinion among large groups of anaesthetists, a large retrospective controlled trial was conducted by the Committee on Anesthesia of the National Academy of Sciences National Research Council of the United States5.This nation-wide study involved 34 centres.Clinical experience of the anaesthetic during the four-year period 1959-1962 was noted.Deaths believed to be associated with massive hepatic necrosis and occurring within six weeks of operation were studied.Liver tissue sections were reviewed by a panel of pathologists with extensive experience in liver disease.The study covered about 850,000 anaesthetics, in about 30% of which halothane was used.The overall mortality was 1.87 % for halothane and 1.93 % for all other anaesthetics.on August 20,
RNA-mediated immunotherapy regulating tumor immune microenvironment: next wave of cancer therapeutics
Authors: Poonam R. Pandey, Ken H. Young, Dhiraj Kumar, Neeraj Jain
Journal: Molecular Cancer (2022)

Abstract Accumulating research suggests that the tumor immune microenvironment (TIME) plays an essential role in regulation of tumor growth and metastasis. The cellular and molecular nature of the TIME influences cancer progression and metastasis by altering the ratio of immune- suppressive versus cytotoxic responses in the vicinity of the tumor. Targeting or activating the TIME components show a promising therapeutic avenue to combat cancer. The success of immunotherapy is both astounding and unsatisfactory in the clinic. Advancements in RNA-based technology have improved understanding of the complexity and diversity of the TIME and its effects on therapy. TIME-related RNA or RNA regulators could be promising targets for anticancer immunotherapy. In this review, we discuss the available RNA-based cancer immunotherapies targeting the TIME. More importantly, we summarize the potential of various RNA-based therapeutics clinically available for cancer treatment. RNA-dependent targeting of the TIME, as monotherapy or combined with other evolving therapeutics, might be beneficial for cancer patients’ treatment in the near future.
Diagnosis and Treatment of Acute Coronary Syndromes
Authors: Deepak L. Bhatt, Renato D. Lopes, Robert A. Harrington
Journal: JAMA (2022)

<h3>Importance</h3> Acute coronary syndromes (ACS) are characterized by a sudden reduction in blood supply to the heart and include ST-segment elevation myocardial infarction (STEMI), non-STEMI (NSTEMI), and unstable angina. Each year, an estimated more than 7 million people in the world are diagnosed with ACS, including more than 1 million patients hospitalized in the US. <h3>Observations</h3> Chest discomfort at rest is the most common presenting symptom of ACS and affects approximately 79% of men and 74% of women presenting with ACS, although approximately 40% of men and 48% of women present with nonspecific symptoms, such as dyspnea, either in isolation or, more commonly, in combination with chest pain. For patients presenting with possible ACS, electrocardiography should be performed immediately (within 10 minutes of presentation) and can distinguish between STEMI and non–ST-segment elevation ACS (NSTE-ACS). STEMI is caused by complete coronary artery occlusion and accounts for approximately 30% of ACS. ACS without significant ST-segment elevation on electrocardiography, termed<i>NSTE-ACS</i>, account for approximately 70% of ACS, are caused by partial or intermittent occlusion of the artery and are associated with ST-segment depressions (approximately 31%), T-wave inversions (approximately 12%), ST-segment depressions combined with T-wave inversions (16%), or neither (approximately 41%). When electrocardiography suggests STEMI, rapid reperfusion with primary percutaneous coronary intervention (PCI) within 120 minutes reduces mortality from 9% to 7%. If PCI within 120 minutes is not possible, fibrinolytic therapy with alteplase, reteplase, or tenecteplase at full dose should be administered for patients younger than 75 years without contraindications and at half dose for patients 75 years or older (or streptokinase at full dose if cost is a consideration), followed by transfer to a facility with the goal of PCI within the next 24 hours. High-sensitivity troponin measurements are the preferred test to evaluate for NSTEMI. In high-risk patients with NSTE-ACS and no contraindications, prompt invasive coronary angiography and percutaneous or surgical revascularization within 24 to 48 hours are associated with a reduction in death from 6.5% to 4.9%. <h3>Conclusions and Relevance</h3> Each year, an estimated more than 7 million people are diagnosed with ACS worldwide. For patients with STEMI, coronary catheterization and PCI within 2 hours of presentation reduces mortality, with fibrinolytic therapy reserved for patients without access to immediate PCI. For high-risk patients with NSTE-ACS without contraindications, prompt invasive coronary angiography followed by percutaneous or surgical revascularization is associated with lower rates of death.
Editorial board
Authors: James Field, Samuel Soskin, Beverly Hills, Garfield Duncan, Salman Azhar, Palo Alto, Hisham Barakat, George Bray, Jorge Calles-Escandon, Jose ´caro, M Charles, George Chrousos, Bernard Bethesda, St Davis, Leslie Louis, Frederick Degroot, Mario Derubertis, Atlanta Digirolamo, William Ga, Louis Duckworth, John Elsas, Kenneth Fain, San Feingold, Andrew Francisco, New Frantz, Saul York, Henry Cleveland, New Ginsberg, Charles York, Jane Glueck, Abbas Cleveland, Fredric Kitabchi, Stanford Kraemer, Nelly Mauras, James May, Donald Mcnamara, Glenn Mortimore, Maria New, New York, Michael Pagliassotti, Ft Collins, William Pandak, Alan Richmond, Los Robinson, Stanton Angeles, Peter Segal, Richard Stacpoole, Marc Durham, John Tucson
Journal: Metabolism (2004)
12. Older Adults:<i>Standards of Medical Care in Diabetes—2021</i>
Journal: Diabetes Care (2020)

The American Diabetes Association (ADA) “Standards of Medical Care in Diabetes” includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, a multidisciplinary expert committee (https://doi.org/10.2337/dc21-SPPC), are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA's clinical practice recommendations, please refer to the Standards of Care Introduction (https://doi.org/10.2337/dc21-SINT). Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
Haematemesis and Melaena
Authors: F. A. Jones
Journal: BMJ (1939)

68 8 17 13 0.20 0.08 0.34 * 10 millimetres= 1 mvNothing abnormal was found in the urine, and as most of it was passed into the bed it was impossible to obtain sufficient to test for porphyrinuria. TREATMENTIn addition to symptomatic treatment with scopolamine, without much benefit, and subcutaneous administration of fluids, we also gave vitamin B,.The patient received a total of 0.55 gramme of thiamin, partly intramuscularly, partly intravenouisly, over a period of two days.There was no improvement; on the contrary, his excitement and confusion were rather increased.One night he was given 0.5 gramme of nicotinic acid by mouth, having already had 0.1 gramme the previous day.Within twelve hours the change that took place was most striking.Whereas the patient had not slept for six days, he now fell into a sound sleep for three hours.When he awoke he was absolutely clear, remained quietly in bed, talked, smoked, ate, and drank without vomiting.During the following three days the stomatitis disappeared, leaving only slight traces, and temperature as well as pulse rate returned to normal.He showed astonishing appetite and thirst: he took three similar meals in quick succession and drank several bottles of sweet grape-juice.In the course of two days his body weight increased from 54.3 kg. to 58 kg., and after two more days to 60 kg.; this was probably partly due to compensation of the previous dehydration.The patient did not remember the events before and after his admission to hospital.
Increased CKMB release is a trade-off for optimal stent implantation: an intravascular ultrasound study
Authors: Ioannis Iakovou, R. Merhan, G. Mintz, G. Dangas, Y. Koboyashi, A. Abizaid, D. Ashby, T. Limpijankit, R. Narasimaiah, I. Hjazi, N. Kipshidze, A.L. Lansky, G.W. Stone, J.W. Moses, M.B. Leon
Journal: Journal of the American College of Cardiology (2002)
NECROLOGY.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal