tbuckley/cabot-search huggingface dataset:
Association Between COVID-19 and Myocarditis Using Hospital-Based Administrative Data — United States, March 2020–January 2021
Authors: Tegan K. Boehmer, Lyudmyla Kompaniyets, Amy M. Lavery, Joy Hsu, Jean Y. Ko, Hussain Yusuf, Sebastian D. Romano, Adi V. Gundlapalli, Matthew E. Oster, Aaron M. Harris
Journal: MMWR Morbidity and Mortality Weekly Report (2021)

Viral infections are a common cause of myocarditis, an inflammation of the heart muscle (myocardium) that can result in hospitalization, heart failure, and sudden death (1).Emerging data suggest an association between COVID-19 and myocarditis (2-5).CDC assessed this association using a large, U.S. hospital-based administrative database of health care encounters from >900 hospitals.Myocarditis inpatient encounters were 42.3% higher in 2020 than in 2019.During March 2020-January 2021, the period that coincided with the COVID-19 pandemic, the risk for myocarditis was 0.146% among patients diagnosed with COVID-19 during an inpatient or hospital-based outpatient encounter and 0.009% among patients who were not diagnosed with COVID-19.After adjusting for patient and hospital characteristics, patients with COVID-19 during March 2020-January 2021 had, on average, 15.7 times the risk for myocarditis compared with those without COVID-19 (95% confidence interval [CI] = 14.1-17.2);by age, risk ratios ranged from approximately 7.0 for patients aged 16-39 years to >30.0 for patients aged <16 years or ≥75 years.Overall, myocarditis was uncommon among persons with and without COVID-19; however, COVID-19 was significantly associated with an increased risk for myocarditis, with risk varying by age group.These findings underscore the importance of implementing evidence-based COVID-19 prevention strategies, including vaccination, to reduce the public health impact of COVID-19 and its associated complications.Data for this study were obtained from the Premier Healthcare Database Special COVID-19 Release (PHD-SR), a large hospital-based administrative database.† The monthly * These authors contributed equally to this report.
Emerging Neuroimaging Biomarkers Across Disease Stage in Parkinson Disease
Authors: Trina Mitchell, Stéphane Lehéricy, Shannon Y. Chiu, Antonio P. Strafella, A. Jon Stoessl, David E. Vaillancourt
Journal: JAMA Neurology (2021)

Imaging biomarkers in Parkinson disease (PD) are increasingly important for monitoring progression in clinical trials and also have the potential to improve clinical care and management. This Review addresses a critical need to make clear the temporal relevance for diagnostic and progression imaging biomarkers to be used by clinicians and researchers over the clinical course of PD. Magnetic resonance imaging (diffusion imaging, neuromelanin-sensitive imaging, iron-sensitive imaging, T1-weighted imaging), positron emission tomography/single-photon emission computed tomography dopaminergic, serotonergic, and cholinergic imaging as well as metabolic and cerebral blood flow network neuroimaging biomarkers in the preclinical, prodromal, early, and moderate to late stages are characterized.
Double-scope rendezvous technique: a safe way to perform an endoscopic ultrasound-guided ileorectal anastomosis after complete stenosis
Authors: Marion Schaefer, Julie Leclerc, Jérémie Albouys, Thomas Lambin, Jérémie Jacques, Thibaut Fouquet, Jean-Baptiste Chevaux
Journal: Endoscopy (2021)

A 56-year-old man underwent subtotal colectomy for sigmoid volvulus with colonic necrosis. Despite a surgical reintervention to redo the ileorectal anastomosis with protective ileostomy, he presented again a complete stenosis without any persistent lumen on computed tomography (CT) and endoscopic evaluation. Therefore, no guidewire could be placed through the stenosis to perform dilation or stenting. With concern about a significant risk of complication of a third surgical intervention and after a multidisciplinary discussion, an endoscopic ultrasound (EUS) recanalization was planned. To assure the procedure, a rendezvous technique was preferred ([Video 1]).
Evaluating the health impacts of a national smokefree prisons policy using trends in medication dispensing: an interrupted time series analysis as part of the Tobacco In Prisons study (TIPs)
Authors: Emily J Tweed, Daniel F Mackay, Kathleen A Boyd, Ashley Brown, Thomas Byrne, Philip Conaglen, Peter Craig, Evangelia Demou, Lesley Graham, Alastair H Leyland, Nicola McMeekin, Jill P Pell, Helen Sweeting, Kate Hunt
Journal: The Lancet Public Health (2021)
A systems approach to elucidate personalized mechanistic complexities of antibody-Fc receptor activation post-vaccination
Authors: Melissa M. Lemke, Milla R. McLean, Christina Y. Lee, Ester Lopez, Emily R. Bozich, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Sven Kratochvil, Bruce D. Wines, P. Mark Hogarth, Stephen J. Kent, Amy W. Chung, Kelly B. Arnold
Journal: Cell Reports Medicine (2021)

Immunoglobulin G (IgG) antibodies that activate Fc-mediated immune functions have been correlated with vaccine efficacy, but it is difficult to unravel the relative roles of multiple IgG and Fc receptor (FcR) features that have the capacity to influence IgG-FcR complex formation but vary on a personalized basis. Here, we develop an ordinary differential-equation model to determine how personalized variability in IgG subclass concentrations and binding affinities influence IgG-FcγRIIIa complex formation and validate it with samples from the HIV RV144 vaccine trial. The model identifies individuals who are sensitive, insensitive, or negatively affected by increases in HIV-specific IgG1, which is validated with the addition of HIV-specific IgG1 monoclonal antibodies to vaccine samples. IgG1 affinity to FcγRIIIa is also prioritized as the most influential parameter for dictating activation broadly across a population. Overall, this work presents a quantitative tool for evaluating personalized differences underlying FcR activation, which is relevant to ongoing efforts to improve vaccine efficacy.
Neurological manifestations of rhino-oculo-cerebral mucormycosis in the COVID-19 era
Authors: Gagandeep Singh, Venugopalan Y. Vishnu
Journal: Nature Reviews Neurology (2021)

In India, the peak of SARS-CoV-2 infections in May 2021 was paralleled by an outbreak of rhino-oculo-cerebral mucormycosis (ROCM) — a fungal infection affecting the nose, eyes and brain. This outbreak provided a unique opportunity to study the neurological manifestations of ROCM and to investigate new treatments for the condition.
JUN promotes hypertrophic skin scarring via CD36 in preclinical in vitro and in vivo models
Authors: Michelle F. Griffin, Mimi R. Borrelli, Julia T. Garcia, Michael Januszyk, Megan King, Tristan Lerbs, Lu Cui, Alessandra L. Moore, Abra H. Shen, Shamik Mascharak, Nestor M. Diaz Deleon, Sandeep Adem, Walter L. Taylor, Heather E. desJardins-Park, Marc Gastou, Ronak A. Patel, Bryan A. Duoto, Jan Sokol, Yuning Wei, Deshka Foster, Kellen Chen, Derrick C. Wan, Geoffrey C. Gurtner, Hermann P. Lorenz, Howard Y. Chang, Gerlinde Wernig, Michael T. Longaker
Journal: Science Translational Medicine (2021)

JUN drives scarring by modifying the roles of fibroblast subpopulations, and JUN antagonism via CD36 may represent an antiscarring therapy.
Photosensitizer with High Efficiency Generated in Cells via Light‐Induced Self‐Oligomerization of 4,6‐Dibromothieno[3,4‐<i>b</i>]thiophene Compound Entailing a Triphenyl Phosphonium Group
Authors: Lingna Wang, Yanyan Huang, Yingjie Yu, Huifei Zhong, Haihua Xiao, Guanxin Zhang, Deqing Zhang
Journal: Advanced Healthcare Materials (2021)

Abstract Photodynamic therapy (PDT) has emerged as an attractive alternative in cancer therapy, but therapeutic effects suffer from low photosensitizing efficiency and poor retention of photosensitizes in cancer cells. This paper reports the photosensitizers which show absorption and emission in the long‐wavelength region and high photosensitizing efficiency can be formed in situ in cells from 4,6‐dibromothieno[3,4‐ b ]thiophene derivative (TT‐5‐P) after white light irradiation. The self‐oligomerization of TT‐5‐P is uptaken in cells upon light irradiation‐induced cell apoptosis simultaneously and efficiently. In addition, the formation of oligomers (TT‐5‐Ps) enhances the retention time in cells remarkably, which is advantageous for boosting the photodynamic therapy efficiency. Moreover, the selectivity toward tumor cells of TT‐5‐P can be improved obviously via the formation of complex of TT‐5‐P with albumin. This in situ photoinduced self‐oligomerization strategy can be utilized to design effective biomaterials for long‐term imaging and improved therapy.
Rapid measurement of SARS-CoV-2 spike T cells in whole blood from vaccinated and naturally infected individuals
Authors: Anthony T. Tan, Joey M.E. Lim, Nina Le Bert, Kamini Kunasegaran, Adeline Chia, Martin D.C. Qui, Nicole Tan, Wan Ni Chia, Ruklanthi de Alwis, Ding Ying, Jean X.Y. Sim, Eng Eong Ooi, Lin-Fa Wang, Mark I-Cheng Chen, Barnaby E. Young, None Li Yang Hsu, Jenny G.H. Low, David C. Lye, Antonio Bertoletti
Journal: Journal of Clinical Investigation (2021)

Defining the correlates of protection necessary to manage the COVID-19 pandemic requires the analysis of both antibody and T cell parameters, but the complexity of traditional tests limits virus-specific T cell measurements. We tested the sensitivity and performance of a simple and rapid SARS-CoV-2 spike protein–specific T cell test based on the stimulation of whole blood with peptides covering the SARS-CoV-2 spike protein, followed by cytokine (IFN-γ, IL-2) measurement in different cohorts including BNT162b2-vaccinated individuals (n = 112), convalescent asymptomatic and symptomatic COVID-19 patients (n = 130), and SARS-CoV-1–convalescent individuals (n = 12). The sensitivity of this rapid test is comparable to that of traditional methods of T cell analysis (ELISPOT, activation-induced marker). Using this test, we observed a similar mean magnitude of T cell responses between the vaccinees and SARS-CoV-2 convalescents 3 months after vaccination or virus priming. However, a wide heterogeneity of the magnitude of spike-specific T cell responses characterized the individual responses, irrespective of the time of analysis. The magnitude of these spike-specific T cell responses cannot be predicted from the neutralizing antibody levels. Hence, both humoral and cellular spike–specific immunity should be tested after vaccination to define the correlates of protection necessary to evaluate current vaccine strategies.
畳込みニューラルネットワークを用いた前立腺MRIの自動セグメンテーション:体積測定とMRI-超音波レジストレーションの精度に対するネットワークアーキテクチャの影響の調査【JST・京大機械翻訳】
Authors: Ghavami Nooshin, Hu Yipeng, Gibson Eli, Bonmati Ester, Emberton Mark, M Moore Caroline, C Barratt Dean
Journal: Medical Image Analysis (2019)
Risk of Rupture After Intracranial Aneurysm Growth
Authors: Laura T. van der Kamp, Gabriel J. E. Rinkel, Dagmar Verbaan, René van den Berg, W. Peter Vandertop, Yuichi Murayama, Toshihiro Ishibashi, Antti Lindgren, Timo Koivisto, Mario Teo, Jerome St George, Ronit Agid, Ivan Radovanovic, Junta Moroi, Keiji Igase, Ido R. van den Wijngaard, Melissa Rahi, Jaakko Rinne, Johanna Kuhmonen, Hieronymus D. Boogaarts, George K. C. Wong, Jill M. Abrigo, Akio Morita, Yoshiaki Shiokawa, Katharina A. M. Hackenberg, Nima Etminan, Irene C. van der Schaaf, Nicolaas P. A. Zuithoff, Mervyn D. I. Vergouwen
Journal: JAMA Neurology (2021)

Unruptured intracranial aneurysms not undergoing preventive endovascular or neurosurgical treatment are often monitored radiologically to detect aneurysm growth, which is associated with an increase in risk of rupture. However, the absolute risk of aneurysm rupture after detection of growth remains unclear. To determine the absolute risk of rupture of an aneurysm after detection of growth during follow-up and to develop a prediction model for rupture. Individual patient data were obtained from 15 international cohorts. Patients 18 years and older who had follow-up imaging for at least 1 untreated unruptured intracranial aneurysm with growth detected at follow-up imaging and with 1 day or longer of follow-up after growth were included. Fusiform or arteriovenous malformation-related aneurysms were excluded. Of the 5166 eligible patients who had follow-up imaging for intracranial aneurysms, 4827 were excluded because no aneurysm growth was detected, and 27 were excluded because they had less than 1 day follow-up after detection of growth. All included aneurysms had growth, defined as 1 mm or greater increase in 1 direction at follow-up imaging. The primary outcome was aneurysm rupture. The absolute risk of rupture was measured with the Kaplan-Meier estimate at 3 time points (6 months, 1 year, and 2 years) after initial growth. Cox proportional hazards regression was used to identify predictors of rupture after growth detection. A total of 312 patients were included (223 [71%] were women; mean [SD] age, 61 [12] years) with 329 aneurysms with growth. During 864 aneurysm-years of follow-up, 25 (7.6%) of these aneurysms ruptured. The absolute risk of rupture after growth was 2.9% (95% CI, 0.9-4.9) at 6 months, 4.3% (95% CI, 1.9-6.7) at 1 year, and 6.0% (95% CI, 2.9-9.1) at 2 years. In multivariable analyses, predictors of rupture were size (7 mm or larger hazard ratio, 3.1; 95% CI, 1.4-7.2), shape (irregular hazard ratio, 2.9; 95% CI, 1.3-6.5), and site (middle cerebral artery hazard ratio, 3.6; 95% CI, 0.8-16.3; anterior cerebral artery, posterior communicating artery, or posterior circulation hazard ratio, 2.8; 95% CI, 0.6-13.0). In the triple-S (size, site, shape) prediction model, the 1-year risk of rupture ranged from 2.1% to 10.6%. Within 1 year after growth detection, rupture occurred in approximately 1 of 25 aneurysms. The triple-S risk prediction model can be used to estimate absolute risk of rupture for the initial period after detection of growth.
Abstract 16227: Myocardial Transcriptomics Reveal Distinct Gene Expression in Human Heart Failure With Preserved Ejection Fraction
Authors: Virginia S Hahn, Hildur Knutsdottir, Joel S Bader, Kenneth C Bedi, Kenneth Margulies, Saptarsi Haldar, Marina Stolina, Jun Yin, Aarif Khakoo, Kavita Sharma, David A Kass
Journal: Circulation (2019)

Introduction: Myocardial biology data of human Heart Failure with Preserved Ejection Fraction (HFpEF) remains limited. We performed RNA-seq in 41 patients with HFpEF, 33 with HFrEF, and 25 controls...
Treatment of Relapsing HPV Diseases by Restored Function of Natural Killer Cells
Authors: Andrea Lisco, Amy P. Hsu, Dimana Dimitrova, Diana M. Proctor, Emily M. Mace, Peiying Ye, Megan V. Anderson, Stephanie N. Hicks, Christopher Grivas, Dima A. Hammoud, Maura Manion, Gabriel J. Starrett, Alvin Farrel, Kerry Dobbs, Isaac Brownell, Christopher Buck, Luigi D. Notarangelo, Jordan S. Orange, Warren J. Leonard, Michael I. Orestes, Anju T. Peters, Jennifer A. Kanakry, Julia A. Segre, Heidi H. Kong, Irini Sereti
Journal: New England Journal of Medicine (2021)

Summ a
Automated facial analysis of infant pain expressions: progress and future directions
Authors: Harriet Oster
Journal: The Lancet Digital Health (2021)

PainChek Infant, a mobile application (app) based on automated facial evaluation and analysis for assessing procedural pain in infants, is a welcome addition to recently developed automated tools for coding infant facial expressions. In The Lancet Digital Health, Kreshnik Hoti and colleagues document the strong psychometric properties and performance of PainChek Infant compared with the widely used manual Neonatal Facial Coding System Revised (NFCS-R).1,2 Both assessments are based on identifying a small number of facial muscle actions (six in PainChek Infant, five in NFCS-R) present in each of four 10 s video segments of infants undergoing an inoculation procedure (baseline, preparation, during, and recovery).
Toward Pediatric T Lymphoblastic Lymphoma Stratification Based on Minimal Disseminated Disease and NOTCH1/FBXW7 Status
Authors: Amélie Trinquand, Adriana Plesa, Chrystelle Abdo, Fabien Subtil, Nathalie Aladjidi, Charlotte Rigaud, Aurore Touzart, Ludovic Lhermitte, Arnaud Petit, Katell Michaux, Charlotte Jung, Catherine Chassagne-Clement, Vahid Asnafi, Yves Bertrand, Nathalie Garnier, Elizabeth Macintyre
Journal: HemaSphere (2021)

While outcome for pediatric T lymphoblastic lymphoma (T-LL) has improved with acute leukemia-type therapy, survival after relapse remains rare. Few prognostic markers have been identified: NOTCH1 and/or FBXW7 ( N/F ) mutations identify good prognosis T-LL and high-level minimal disseminated disease (MDD) is reported to be of poor prognosis. We evaluated MDD and/or MRD status by 8-color flow cytometry and/or digital droplet PCR in 82 pediatric T-LL treated according to the EURO-LB02 prednisone reference arm. Both techniques gave identical results for values ≥0.1%, allowing compilation. Unlike historical studies, an MDD threshold of 1% had no prognostic significance. The 54% (42/78) of patients with MDD ≥0.1% had a relatively favorable outcome (5-y overall survival [OS] 97.6% versus 80.6%, P = 0.015, 5-y event-free-survival [EFS] 95.2% versus 80.6%, P = 0.049). MDD lower than 0.1% had no impact in N/F mutated T-LL, but identified the N/F germline patient with a high risk of relapse. Combining oncogenetic and MDD status identified 86% of patients (n = 49) with an excellent outcome and 14% of N/F germline/MDD &lt;0.1% patients (n = 8) with poor prognosis (5y-OS 95.9% versus 37.5%, P &lt; 0.001; 5y-EFS 93.9% versus 37.5%, P &lt; 0.001). If confirmed by prospective studies, MDD and N/F mutational status would allow identification of a subset of patients who merit consideration for alternative front-line treatment.
The Effect of Tailored Home Hazard Removal on Falls Among Community-Dwelling Older Adults
Authors: Sarah L. Szanton, Melissa D. Hladek
Journal: JAMA Network Open (2021)

Susan Stark, PhD; Marian Keglovits, OTD; Emily Somerville, OTD; Yi-Ling Hu, PhD; Abigail Barker, PhD; Dave Sykora, BS; Yan Yan, MD, PhD
ヒト白血病細胞に対する新しいグアニン四重鎖双方向テロメラーゼ阻害剤(SOT-095)の活性:ATM依存DNA損傷反応経路の関係
Authors: Tauchi T, Shin-Ya K, Sashida G, Sumi M, Nakajima A, Ohyashiki Jh, Ohyashiki K
Journal: Blood (2003)
Caspase-cleavable peptide-doxorubicin conjugate in combination with CD47-antagonizing nanocage therapeutics for immune-mediated elimination of colorectal cancer
Authors: Na Kyeong Lee, Jeong Uk Choi, Ha Rin Kim, Seung Woo Chung, Yoon Gun Ko, Young Seok Cho, Seong Jin Park, Eun Jung Lee, Sang Yoon Kim, In-San Kim, Youngro Byun
Journal: Biomaterials (2021)

Here we report a novel combination of a caspase-cleavable peptide-doxorubicin conjugate (MPD-1) with CD47-antagonizing nanocage therapeutics for the treatment of microsatellite-stable (MSS) colorectal cancer (CRC). MPD-1 (i) upregulated markers of immunogenic cell death (ICD) in tumor, and increased co-stimulatory markers on dendritic cells (DCs), (ii) enhanced CD8+ T cell infiltration and antigen presenting cell (APC) activation, and (iii) showed negligible off-target immune-related toxicity compared to free dox. Then, the CD47 antagonist FS nanocage, a SIRPα-expressing ferritin nanocage, was co-administered with MPD-1 that resulted in 95.2% (p < 0.001) tumor growth inhibition in an established CRC model. T cell-mediated elimination of tumors was also confirmed by the tumor-specific activation of T cells detected by IFNγ and tumor-free mice were observed (95%) that bared a memory response when re-challenged. The strategically developed MPD-1 is an ideal adjuvant to immunotherapy and the combination with FS nanocage triggers potent immunity against MSS CRC. In summary, we present an approach to initiate and stimulate immune-mediated eradication of cancer cells using synergistic immunogenic agents targeting the MSS CRC.
Multiple-Organ Involvement in Familial Hemophagocytic Lymphohistiocytosis Type 2 Shown on FDG PET/CT
Authors: Wei Wang, Xu Yang, Jigang Yang
Journal: Clinical Nuclear Medicine (2021)

Abstract FDG PET/CT in an 18-year-old man with known familial hemophagocytic lymphohistiocytosis (HLH) type 2 demonstrated abnormally in the brain, liver, and lymph nodes. Pathology showed no sign of lymphoproliferative disease. The patient underwent the chemotherapy of HLH. Six months after chemotherapy, a follow-up FDG PET/CT did not show any abnormal 18 F-FDG activity, suggesting a complete response. The present case shows FDG PET/CT might not only be useful in staging the familial HLH but also able to evaluate the therapy response.
Cervical cancer prevention and control in women living with human immunodeficiency virus
Authors: Philip E. Castle, Mark H. Einstein, Vikrant V. Sahasrabuddhe
Journal: CA A Cancer Journal for Clinicians (2021)

Abstract Despite being highly preventable, cervical cancer is the fourth most common cancer and cause of cancer death in women globally. In low‐income countries, cervical cancer is often the leading cause of cancer‐related morbidity and mortality. Women living with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome are at a particularly high risk of cervical cancer because of an impaired immune response to human papillomavirus, the obligate cause of virtually all cervical cancers. Globally, approximately 1 in 20 cervical cancers is attributable to HIV; in sub‐Saharan Africa, approximately 1 in 5 cervical cancers is due to HIV. Here, the authors provide a critical appraisal of the evidence to date on the impact of HIV disease on cervical cancer risk, describe key methodologic issues, and frame the key outstanding research questions, especially as they apply to ongoing global efforts for prevention and control of cervical cancer. Expanded efforts to integrate HIV care with cervical cancer prevention and control, and vice versa, could assist the global effort to eliminate cervical cancer as a public health problem.
再発性または難治性の原発性CNSリンパ腫(PCNSL)のための血液脳関門破壊およびICEレジメンの組合せにおけるリツキシマブによる免疫化学療法
Authors: Nishikawa R, Matsutani M, Yamane F, Ishihara S, Wakiya K, Adachi J, Uemiya N, Suzuki T, Mishima K
Journal: Neuro-Oncology (2009)
In acute atrial flutter, adding pharmacologic before electrical cardioversion did not increase conversion to normal sinus rhythm
Authors: Christopher Sampson
Journal: Annals of Internal Medicine (2021)

Source Citation Stiell IG, Sivilotti MLA, Taljaard M, et al. A randomized, controlled comparison of electrical versus pharmacological cardioversion for emergency department patients with acute atrial flutter. CJEM. 2021;23:314-24. 33959925