tbuckley/cabot-search huggingface dataset:
Psychiatry
Authors: Frederick K. Goodwin
Journal: JAMA (1994)

Last year's congressionally mandated reunion of the National Institute of Mental Health with the National Institutes of Health signaled recognition of the maturity of basic and clinical psychiatric research. This maturity is evident in the body of epidemiologic, economic, and treatment data, presented to the President's Task Force on National Health Care Reform, that convincingly dispels three key myths about mental illness: Mental illness is not definable. In fact, the diagnostic reliability for diagnoses of major mental illnesses equals that achieved for diagnoses in other areas of medicine. Multiple clinicians independently agree on the diagnosis of a major mental disorder approximately 80% of the time.<sup>1</sup> Mental illnesses are not treatable, or "everything sort of works for everything." In fact, outcome research documents that specific treatments for major mental disorders yield success rates in the 60% to 80% range. When assessed by the same criteria applied to determine "successful outcome" of
Film Reviews
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sensitization to Malassezia Sympodialis is Associated with Low Efficacy of Local Anti-inflammatory Therapy in Patients with Contact Dermatitis
Authors: Olexandr Litus, Yuriy Bisyuk, Lyudmyla Konovalenko, Viktor Litus, Bohdan Lytvynenko, Lawrence DuBuske
Journal: Journal of Allergy and Clinical Immunology (2022)
Intestinal Barrier Dysfunction Accompanies Peanut Allergy In A Genetically-Susceptible Mouse Model And Identifies Angiopoietin-like 4 As A Biomarker
Authors: Erin Steinbach, Johanna Smeekens, Satyaki Roy, Takahiko Toyonaga, Caleb Cornaby, Layna Perini, Ana Berglind, Michael Kulis, Edwin Kim, Martin Ferris, Terrence Furey, A. Wesley Burks, Shehzad Sheikh
Journal: Journal of Allergy and Clinical Immunology (2022)
Bacteriology and Surgery of Chronic Arthritis and Rheumatism with End-Results of Treatment.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transesophageal echocardiography improves risk assessment of thrombolysis of prosthetic value thrombosis: Results of the international PRO-TEE registry
Authors: Ann T. Tong, Raymond Roudaut, Mehmet Ozkan, Alex Sagie, Maie S. Shahid, Sergio C. Pontes, Francesc Carreras, Steven E. Girard, Samir Arnaout, Raymond F. Stainback, Ravi Thadhani, William A. Zoghbi
Journal: Journal of the American College of Cardiology (2003)
Six million patients wait as politicians argue over the elective recovery plan
Authors: Chris Ham
Journal: BMJ (2022)

Six million patients wait as politicians argue over the elective recovery plan Chris HamPlans to tackle the backlog of routine care in the NHS in England, due to be published today, have been delayed because of disagreement within the government over the weekend.Reports indicate that disagreement centred on the Treasury's concerns about the targets for reducing the backlog and more significantly on the reluctance of the Chancellor of the Exchequer to provide the prime minister with ammunition to bolster his credibility after Sue Gray's report into the partygate affair. 1 Patients have been left in limbo until these differences can be resolved.
Natalizumab treatment for multiple sclerosis: recommendations for patient selection and monitoring
Authors: Ludwig Kappos, David Bates, Hans-Peter Hartung, Eva Havrdova, David Miller, Chris H Polman, Mads Ravnborg, Stephen L Hauser, Richard A Rudick, Howard L Weiner, Paul W O'Connor, John King, Ernst Wilhelm Radue, Tarek Yousry, Eugene O Major, David B Clifford
Journal: The Lancet Neurology (2007)
On Tumors of the Bladder, their Nature, Symptoms and Surgical Treatment, Preceded by a Consideration of the best Methods of Diagnosing all forms of Vesical Disease, including Digital Exploration and its Results
Authors: None E. W. A.
Journal: JAMA (1884)

We believe this monograph is the first important contribution to the new and important question of digital exploration of the bladder. Although the work is entitled "Tumors of the Bladder," yet the vital part of it is contained in the discussion of cystotomy as a justifiable resource in obscure cases of bladder disease, as a step toward diagnosis by digital exploration of the interior of that organ. This is true first, because no case of tumor can be diagnosed or treated without cystotomy as a preliminary step, and, secondly, because the operation, which is not a serious one, gives marked relief in a large number of cases, even where no tumor is found which can be removed. The relief thus seen to follow, is due to the perfect<i>rest</i>from distension, tenesmus and catheterization which the perineal opening allows to the inflamed organ. Primarily, therefore, this little book sets out
A2B-COVID: A Tool for Rapidly Evaluating Potential SARS-CoV-2 Transmission Events
Authors: Christopher J R Illingworth, William L Hamilton, Christopher Jackson, Ben Warne, Ashley Popay, Luke Meredith, Myra Hosmillo, Aminu Jahun, Tom Fieldman, Matthew Routledge, Charlotte J Houldcroft, Laura Caller, Sarah Caddy, Anna Yakovleva, Grant Hall, Fahad A Khokhar, Theresa Feltwell, Malte L Pinckert, Iliana Georgana, Yasmin Chaudhry, Martin Curran, Surendra Parmar, Dominic Sparkes, Lucy Rivett, Nick K Jones, Sushmita Sridhar, Sally Forrest, Tom Dymond, Kayleigh Grainger, Chris Workman, Effrossyni Gkrania-Klotsas, Nicholas M Brown, Michael P Weekes, Stephen Baker, Sharon J Peacock, Theodore Gouliouris, Ian Goodfellow, Daniela De Angelis, M Estée Török
Journal: Molecular Biology and Evolution (2022)

Abstract Identifying linked cases of infection is a critical component of the public health response to viral infectious diseases. In a clinical context, there is a need to make rapid assessments of whether cases of infection have arrived independently onto a ward, or are potentially linked via direct transmission. Viral genome sequence data are of great value in making these assessments, but are often not the only form of data available. Here, we describe A2B-COVID, a method for the rapid identification of potentially linked cases of COVID-19 infection designed for clinical settings. Our method combines knowledge about infection dynamics, data describing the movements of individuals, and evolutionary analysis of genome sequences to assess whether data collected from cases of infection are consistent or inconsistent with linkage via direct transmission. A retrospective analysis of data from two wards at Cambridge University Hospitals NHS Foundation Trust during the first wave of the pandemic showed qualitatively different patterns of linkage between cases on designated COVID-19 and non-COVID-19 wards. The subsequent real-time application of our method to data from the second epidemic wave highlights its value for monitoring cases of infection in a clinical context.
“Excess deaths” is the best metric for tracking the pandemic
Authors: Nazrul Islam
Journal: BMJ (2022)

Excess deaths" is the best metric for tracking the pandemic It's more informative and accurate than covid-19 deaths or cases Nazrul Islam epidemiologistSince the emergence of the covid-19 pandemic in early 2020, governments and international agencies have reported regular data on covid-19 cases and deaths.These metrics have consistently been used to track the pandemic's effects on human lives.But the pandemic is not just about illnesses and deaths caused by SARS-CoV-2.It has far reaching effects-direct and indirect-with short and long term consequences for both individuals and populations. 1 2Deaths from covid-19 account for only a fraction of the short term direct effects of SARS-CoV-2.Other critical outcomes include hospital admission, mechanical ventilation, and need for intensive care.Medium to long term direct effects include loss of smell and taste, chronic fatigue, breathlessness, chest pain, and arrhythmias.
<i>Announcement:</i>World Birth Defects Day — March 3, 2017
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

Every year, approximately 3%-6% of infants worldwide are born with a serious birth defect (1-5). Birth defects can affect an infant regardless of birthplace, race, or ethnicity. In many countries, birth defects are among the leading causes of death for infants and young children (6). Those who survive and live with these conditions are at an increased risk for lifelong disabilities.
A New Oral Diuretic
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Long-term efficacy and safety of addition of carboplatin with or without veliparib to standard neoadjuvant chemotherapy in triple-negative breast cancer: 4-year follow-up data from BrighTNess, a randomized phase III trial
Authors: C.E. Geyer, W.M. Sikov, J. Huober, H.S. Rugo, N. Wolmark, J. O’Shaughnessy, D. Maag, M. Untch, M. Golshan, J. Ponce Lorenzo, O. Metzger, M. Dunbar, W.F. Symmans, P. Rastogi, J.H. Sohn, R. Young, G.S. Wright, C. Harkness, K. McIntyre, D. Yardley, S. Loibl
Journal: Annals of Oncology (2022)

Primary analyses of the phase III BrighTNess trial showed addition of carboplatin with/without veliparib to neoadjuvant chemotherapy significantly improved pathological complete response (pCR) rates with manageable acute toxicity in patients with triple-negative breast cancer (TNBC). Here, we report 4.5-year follow-up data from the trial.Women with untreated stage II-III TNBC were randomized (2 : 1 : 1) to paclitaxel (weekly for 12 doses) plus: (i) carboplatin (every 3 weeks for four cycles) plus veliparib (twice daily); (ii) carboplatin plus veliparib placebo; or (iii) carboplatin placebo plus veliparib placebo. All patients then received doxorubicin and cyclophosphamide every 2-3 weeks for four cycles. The primary endpoint was pCR. Secondary endpoints included event-free survival (EFS), overall survival (OS), and safety. Since the co-primary endpoint of increased pCR with carboplatin plus veliparib with paclitaxel versus carboplatin with paclitaxel was not met, secondary analyses are descriptive.Of 634 patients, 316 were randomized to carboplatin plus veliparib with paclitaxel, 160 to carboplatin with paclitaxel, and 158 to paclitaxel. With median follow-up of 4.5 years, the hazard ratio for EFS for carboplatin plus veliparib with paclitaxel versus paclitaxel was 0.63 [95% confidence interval (CI) 0.43-0.92, P = 0.02], but 1.12 (95% CI 0.72-1.72, P = 0.62) for carboplatin plus veliparib with paclitaxel versus carboplatin with paclitaxel. In post hoc analysis, the hazard ratio for EFS was 0.57 (95% CI 0.36-0.91, P = 0.02) for carboplatin with paclitaxel versus paclitaxel. OS did not differ significantly between treatment arms, nor did rates of myelodysplastic syndromes, acute myeloid leukemia, or other secondary malignancies.Improvement in pCR with the addition of carboplatin was associated with long-term EFS benefit with a manageable safety profile, and without increasing the risk of second malignancies, whereas adding veliparib did not impact EFS. These findings support the addition of carboplatin to weekly paclitaxel followed by doxorubicin and cyclophosphamide neoadjuvant chemotherapy for early-stage TNBC.
A distinct hypothalamus-to-β cell circuit modulates insulin secretion
Authors: Ioannis Papazoglou, Ji-Hyeon Lee, Zhenzhong Cui, Chia Li, Gianluca Fulgenzi, Young Jae Bahn, Halina M. Staniszewska-Goraczniak, Ramón A. Piñol, Ian B. Hogue, Lynn W. Enquist, Michael J. Krashes, Sushil G. Rane
Journal: Cell Metabolism (2022)
Transcriptional Profiling of Mouse Eosinophils Identifies Unique Activation Signature Following Polarization
Authors: Avishay Dolitzky, Guy Shapira, Sharon Grisaru, Inbal Hazut, Shmulik Avlas, Micahl Itan, Noam Shomron, Ariel Munitz
Journal: Journal of Allergy and Clinical Immunology (2022)
NEW FORM OF IODINE TREATMENT FOR TUBERCULOSIS.
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New Therapeutic Strategies Have Changed the Natural History of Pediatric Crohn’s Disease: A Two-Decade Population-Based Study
Authors: Delphine Ley, Ariane Leroyer, Claire Dupont, Hélène Sarter, Valérie Bertrand, Claire Spyckerelle, Nathalie Guillon, Pauline Wils, Guillaume Savoye, Dominique Turck, Corinne Gower-Rousseau, Mathurin Fumery
Journal: Clinical Gastroenterology and Hepatology (2022)
Meet the First Authors
Authors: Saad Samargandy
Journal: Circulation Research (2022)

where he focused his training on the epidemiology of CVD in midlife women.He published research that showed arterial stiffness and abdominal visceral adipose tissue increasing around menopause.In this issue of Circulation Research, he and his colleagues were able to show that the menopause transition is also a predictor of accelerated increases in blood pressure in midlife women.He enjoys reading books in social psychology and practices woodworking as a hobby.He can be found on Twitter @dr_saadss.
Bronchodilator response assessed by oscillometry identifies uncontrolled asthma with more sensitivity than spirometry
Authors: Hiromasa Nakayasu, Toshihiro Shirai, Taisuke Akamatsu, Shuichi Sugiyama, Kotaro Shiratori, Kohei Okawa, Toshihiro Masuda, Shingo Takahashi, Yoshihiro Kitahara, Yutaro Kishimoto, Shogo Sakurai, Mika Saigusa, Akito Yamamoto, Satoru Morita, Kazuhiro Asada
Journal: Journal of Allergy and Clinical Immunology (2022)
Forskolin-induced organoid swelling is associated with long-term cystic fibrosis disease progression
Authors: Danya Muilwijk, Eyleen de Poel, Peter van Mourik, Sylvia W.F. Suen, Annelotte M. Vonk, Jesse E. Brunsveld, Evelien Kruisselbrink, Hugo Oppelaar, Marne C. Hagemeijer, Gitte Berkers, Karin M. de Winter-de Groot, Sabine Heida-Michel, Stephan R. Jans, Hannah van Panhuis, Menno M. van der Eerden, Renske van der Meer, Jolt Roukema, Edward Dompeling, Els J.M. Weersink, Gerard H. Koppelman, Robert Vries, Domenique D. Zomer-van Ommen, Marinus J.C. Eijkemans, Cornelis K. van der Ent, Jeffrey M. Beekman
Journal: European Respiratory Journal (2022)

Rationale Cystic fibrosis (CF) is a monogenic life-shortening disease associated with highly variable individual disease progression which is difficult to predict. Here we assessed the association of forskolin-induced swelling (FIS) of patient-derived organoids with long-term CF disease progression in multiple organs and compared FIS with the golden standard biomarker sweat chloride concentration (SCC). Methods We retrieved 9-year longitudinal clinical data from the Dutch CF Registry of 173 people with mutations in the cystic fibrosis transmembrane conductance regulator ( CFTR ) gene. Individual CFTR function was defined by FIS, measured as the relative size increase of intestinal organoids after stimulation with 0.8 µM forskolin, quantified as area under the curve (AUC). We used linear mixed-effect models and multivariable logistic regression to estimate the association of FIS with long-term forced expiratory volume in 1 s % predicted (FEV 1 pp) decline and development of pancreatic insufficiency, CF-related liver disease and diabetes. Within these models, FIS was compared with SCC. Results FIS was strongly associated with longitudinal changes of lung function, with an estimated difference in annual FEV 1 pp decline of 0.32% (95% CI 0.11–0.54%; p=0.004) per 1000-point change in AUC. Moreover, increasing FIS levels were associated with lower odds of developing pancreatic insufficiency (adjusted OR 0.18, 95% CI 0.07–0.46; p&lt;0.001), CF-related liver disease (adjusted OR 0.18, 95% CI 0.06–0.54; p=0.002) and diabetes (adjusted OR 0.34, 95% CI 0.12–0.97; p=0.044). These associations were absent for SCC. Conclusion This study exemplifies the prognostic value of a patient-derived organoid-based biomarker within a clinical setting, which is especially important for people carrying rare CFTR mutations with unclear clinical consequences.
Books Received
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dual-responsive nanodroplets combined with ultrasound-targeted microbubble destruction suppress tumor growth and metastasis via autophagy blockade
Authors: Xiaoxuan Wang, Mengmeng Shang, Xiao Sun, Lu Guo, Shan Xiao, Dandan Shi, Dong Meng, Yading Zhao, Lizhi Yang, Chao Jiang, Jie Li
Journal: Journal of Controlled Release (2022)

The inhibition of autophagy is a feasible clinical strategy in tumor therapy. Traditional autophagy inhibitors are limited in clinical tumor therapy due to nonspecific biodistribution, systemic toxicity and limited antitumor effect. Herein, the autophagy inhibitor hydroxychloroquine (HCQ)-loaded nanodroplets (NDs) are synthesized to overcome these drawbacks. HCQ-NDs are endowed with endogenous pH- and exogenous ultrasound-responsive drug release and contrast enhanced ultrasound imaging performance. The combined application of ultrasound-targeted microbubble destruction (UTMD) and HCQ-NDs can severely break the homeostasis of tumor cells, simultaneously releasing HCQ rapidly to block autophagic flux and thus abolish the cytoprotective function. This strategy presents strong synergistic antitumor efficacy with the tumor growth inhibition value of 80.02% and synchronously inhibits tumor lung metastasis by inhibition of MMP2 and MMP9 production, eventually leading to tumor suppression. In addition, HCQ-NDs show excellent tumor-targeting, biocompatibility, biosafety and contrast-enhanced ultrasound imaging properties. Based on the above findings, this combined strategy rationally regulates the autophagic process of tumor cells and could be instructive for the design of clinical treatment modalities.