tbuckley/cabot-search huggingface dataset:
P116: THE IMPACT OF COVID19 PANDEMIC ON SICKLE CELL MANAGEMENT: EXPERIENCE OF A SINGLE PEDIATRIC CENTER
Authors: M Maria Vousvouki, A Aikaterini Teli, A Alkistis Adramerina, S Stamatia Theodoridou, M Marina Economou
Journal: HemaSphere (2022)

Background: COVID19 pandemic has put an incomparable pressure on all health services – including those offered to hemoglobinopathy patients. Sickle cell disease management, although not routinely requiring inpatient facilities, is dependent upon hospital based services on a great extent. Aims: Aim of the present study was to evaluate the impact of COVID19 pandemic on medical management of sickle cell disease patients followed at a single pediatric center in Northern Greece. Methods: Patient records were reviewed in order to assess changes reflecting limited access to specialized care, i.e. number of disease related complications, number of hospital routine visits and number of disease related hospitalizations, during the 18month pandemic in Greece. Results: The study included 23 patients, 17 female (74%) and 6 male (26%). Age range was 2 to 19 years. Eighteen (18) patients (78.3%) were double heterozygotes for sickle cell and beta thalassemia, 4 (17.4%) were sickle cell homozygotes and 1 patient (4.3%) was double heterozygote for sickle cell disease and hemoglobinopathy D. Out of 23 patients, 4 were on regular blood transfusions due disease related issues (primary prophylaxis for cerebrovascular disease or hypersplenism in 2 cases, severe anemia or repeated pain crises in 2 other cases). No significant difference was recorded in number of hospital visits during the 18month period before and during the pandemic (5.45 visits/year and 6 visits/year, respectively – p = 0.49), reflecting a stable course for patients not receiving regular transfusions and an unaffected by blood shortage or limited hospital access course for regularly transfused patients. To that end, no significant changes were recorded in non-COVID related hospitalizations between the two groups (0.57/year before the pandemic and 0.39/year during the pandemic, p = 0.32). In addition, no difference was found between the reported number of pain crises (0.63 episodes per year vs 0.63 episodes per year, p = 1.0). An otherwise unremarkable overall clinical and laboratory course was reported for all patients during the two time periods compared. No changes in regular monitoring was noted and no changes in drug prescription or drug availability for patients on hydroxyurea was recorded. Summary-Conclusions: Although sickle cell patients require close monitoring, mostly dependent upon hospital based services, the COVID19 pandemic does not seem to have limited access to recommended care in this patient group. References 1. Orphanet J Rare Dis 2021 Mar 1;16(1):114
Thermography finds multitude of applications
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THYROIDITIS
Authors: G CRILE
Journal: Annals of Internal Medicine (1952)

Article1 September 1952THYROIDITISGEORGE CRILE JR., M.D.GEORGE CRILE JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-37-3-519 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe main reason for the progressive increase in the incidence of thyroiditis is better recognition. Nevertheless, the diagnosis of thyroiditis is still missed frequently or made late.Since surgical intervention is rarely necessary in the treatment of thyroiditis, and since effective medical and radiologic treatment is available, it is extremely important that the diagnosis be made accurately and promptly so that needless operations can be avoided. This can best be done by bearing the possibility of thyroiditis in mind in connection with any enlargement of the thyroid and by confirming the diagnosis in questionable cases by biopsy of the thyroid...Bibliography1. KingRosellini BTLJ: Treatment of acute thyroiditis with thiouracil, J. A. M. A. 129: 267-268 (Sept. 22) 1945. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cleveland, Ohio*Presented at the thirty-third Annual Session of the American College of Physicians, Cleveland, Ohio, April 25, 1952. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPsychiatric manifestations of Hashimoto's thyroiditisDe Quervain's subacute thyroiditisZusammentreffen von Immunthyreoiditis und SchilddrüsenneoplasmenSubacute thyroiditisDie Strahlentherapie gutartiger Erkrankungen innersekretorischer DrüsenDie Strahlentherapie gutartiger Erkrankungen innersekretorischer DrüsenREFERENCESAuto-Immune Thyroiditis in Children and Adolescents: I. Clinical StudiesDie ImmunthyreoiditisSubacute Diffuse ThyroiditisSUBACUTE GRANULOMATOUS THYROIDITIS: A REVIEW*FRANZ U. STEINBERG, M.D., F.A.C.P.Subacute Thyroiditis Treated with SalicylateDie SchilddrüseTHE PLURIGLANDULAR SYNDROME, WITH THE REPORT OF A CASECORTISONE VERSUS X-RAY IN THE TREATMENT OF SUBACUTE THYROIDITIS: A REPORT OF FOUR CASES*LAWRENCE TAYLOR, M.D.SUBACUTE NON-SUPPURATIVE THYROIDITISMetastatische nekrotisierende Thyreoiditis durch Pseudomonas pyocyaneaMYXEDEMA IN TWO BROTHERS, ONE WITH PSYCHOSIS*†WILLIAM N. CHAMBERS, M.D., F.A.C.P., JOHN MILNE, M.D., F.A.C.P.Krankheiten der SchilddrüseThyroiditis 1 September 1952Volume 37, Issue 3Page: 519-524KeywordsBiopsyThyroid ePublished: 1 December 2008 Issue Published: 1 September 1952 PDF downloadLoading ...
Information, computers, and clinical practice
Authors: D. Levinson
Journal: JAMA (1983)

INFORMATION management is integral to clinical practice. Clinicians and patients interact within a complex information matrix. The physician is an information manager who acquires, processes, stores, retrieves, and applies information related to (1) individual patient history and clinical course, (2) diagnostic and therapeutic protocols, (3) disease patterns in patient populations, (4) functioning of the health care system, and (5) the vast store of published knowledge. Little occurs in the clinical encounter that is not in some way related to obtaining, processing, or applying information. Optimal performance of clinical informational tasks has for years exceeded the cognitive capability of the human mind; the physician-patient interaction is an individual, handcrafted activity of uneven quality. The facts of the clinical history depend on the patient's often inadequate recall, the physician's intuitive problem-solving strategies, the time and emotional constraints of the interview, and an archaic record system. Diagnosis is an uncertain science, reflecting the
A lack of climate finance is harming population health
Authors: Paul Watkiss, Kristie L Ebi
Journal: BMJ (2022)

Recent climate change already has negative effects on human health and projected climate change is expected to contribute to substantial increases in morbidity and mortality associated with a range of health outcomes. 1 The two main policy responses are mitigation to reduce global emissions of greenhouse gases to decrease the magnitude of health risks later this century, and adaptation to prepare for and minimize the negative health impacts of climate change.National planning on climate change is advancing.
Child Survival and Early Lifetime Exposures to Ambient Fine Particulate Matter in India: A Retrospective Cohort Study
Authors: Jiawen Liao, Yang Liu, Kyle Steenland, Ajay Pillarisetti, Lisa M. Thompson, Sagnik Dey, Kalpana Balakrishnan, Thomas Clasen
Journal: Environmental Health Perspectives (2022)

Background: Ambient fine particulate matter [PM ≤2.5μm in aerodynamic diameter (PM2.5)] is a major health risk for children, particularly in South Asia, which currently experiences the highest PM2.5 levels globally. Nevertheless, there is comparatively little epidemiological evidence from this region to quantify the effects of PM2.5 on child survival. Objectives: We estimated the association between PM2.5 exposure and child survival in India. Methods: We constructed a large, retrospective, and nationally representative cohort of children <5 years of age, born between 2009–2016, from the publicly available, cross-sectional 2015–2016 Demographic Health Surveys in India. In utero and post-delivery lifetime average ambient PM2.5 exposures were estimated with data from satellite remote sensing, meteorology, and land use information (model R2= 0.82). We used Cox proportional hazards regression to estimate the association between both average in utero and post-delivery lifetime PM2.5 and all-cause child mortality, controlling for individual- and household-level covariates, seasonality, location, and meteorology. Results: Over 7,447,724 child-months of follow-up, there were 11,559 deaths at <5 years of age reported by the children’s mothers. The mean concentrations of 9-month in utero and post-delivery lifetime average ambient PM2.5 exposure were 71.1 μg/m3 (range: 20.9–153.5 μg/m3) and 73.7 μg/m3 (range: 14.0–247.3 μg/m3), respectively. Estimated child mortality adjusted hazard ratios were 1.023 [95% confidence interval (CI): 1.008, 1.038] and 1.013 (95% CI: 1.001, 1.026) per 10-μg/m3 increase of in utero and post-delivery lifetime PM2.5, with both exposures in the model. Discussion: This study adds to the growing body of evidence about the adverse health effects of PM2.5 by demonstrating the association between exposure, both in utero and post-delivery, on child survival at the national level in India. Strategies to reduce ambient air pollution levels, including steps to minimize in utero and early life exposures, are urgently needed in India and other countries where exposures are above recommended guideline values. https://doi.org/10.1289/EHP8910
A guideline for the clinical management of patients with basal cell naevus syndrome (Gorlin syndrome)
Journal: British Journal of Dermatology (2022)

Journal Article A guideline for the clinical management of patients with basal cell naevus syndrome (Gorlin syndrome) Get access British Journal of Dermatology, Volume 186, Issue 2, 1 February 2022, Page e86, https://doi.org/10.1111/bjd.20914 Published: 01 February 2022
Trajectories of precarious employment and the risk of myocardial infarction and stroke among middle-aged workers in Sweden: A register-based cohort study
Authors: Nuria Matilla-Santander, Carles Muntaner, Bertina Kreshpaj, Virginia Gunn, Johanna Jonsson, Lauri Kokkinen, Jenny Selander, Sherry L Baron, Cecilia Orellana, Per-Olof Östergren, Tomas Hemmingsson, David H. Wegman, Theo Bodin
Journal: The Lancet Regional Health - Europe (2022)

The aim is to identify trajectories of precarious employment (PE) over time in Sweden to examine associations of these with the subsequent risk of myocardial infarction (MI) and stroke.This is a nation-wide register-based cohort study of 1,583,957 individuals aged 40 to 61 years old residing in Sweden between 2003-2007. Trajectories of PE as a multidimensional construct and single PE components (contractual employment relationship, temporariness, income levels, multiple job holding, probability of coverage by collective agreements) were identified for 2003-2007 by means of group-based model trajectories. Risk Ratios (RR) for MI and stroke according to PE trajectories were calculated by means of generalized linear models with binomial family.Adjusted estimates showed that constant PE and borderline PE trajectories increased the risk of MI (RR: 1·08, CI95%:1·05-1·11 and RR:1·13, CI95%: 1·07-1·20 respectively) and stroke (RR:1·14, CI95%: 1·10-1·18 and HR:1·24, CI95%: 1·16-1·33 respectively) among men. A higher risk of stroke in men was found for the following unidimensional trajectories: former agency employees (RR:1·32, CI95%:1·04-1·68); moving from high to a low probability of having collective agreements (RR: 1·10, CI95%:1·01-1·20). Having constant low or very low income was associated to an increased risk of MI and Stroke for both men and women.The study findings provide evidence that PE increases the risk of stroke and possibly MI. It highlights the importance of being covered by collective bargaining agreements, being directly employed and having sufficient income levels over time.The Swedish Research Council for Health, Working Life and Welfare, no. 2019-01226.
Health-related quality of life outcomes in a Phase 2b Randomized Trial evaluating the effectiveness and safety of Probiotic Peanut Oral Immunotherapy
Authors: Melanie Lloyd, Paxton Loke, Sarah Ashley, Adriana Lozinsky, Francesca Orsini, Michael Gold, Michael O'Sullivan, Susan Prescott, Katrina Allen, Sigrid Pitkin, Christine Axelrad, Dean Tey, Marnie Robinson, Ee Lyn Su, Jessica Metcalfe, Audrey Dunn Galvin, Mimi Tang
Journal: Journal of Allergy and Clinical Immunology (2022)
Jejunal Diverticula
Authors: P VUORINEN
Journal: BMJ (1963)

BRITISH MEDICAL TOLJRNALas well as other local authorities.The Home Secretary suggests3 liaison with housing authorities, voluntary organizations, local churches, and social-welfare charities.Charities may be able to help with their funds.The Home Secretary also suggests the provision of family advice centres where help can be sought and information and assistance given.Besides giving advice and guidance the councils will be empowered to give assistance in kind or in exceptional circumstances in cash.Assistance in kind may take such forms as bedding, kitchen equipment, or fuel, and cash assistance may be either by outright grant or by way of a loan.The councils will be unfettered in their decisions on the manner in which they will provide the required advice, guidance, and assistance, and all will have great
Current Medical Literature
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adenovirus-based vaccines—a platform for pandemic preparedness against emerging viral pathogens
Authors: Lynda Coughlan, Eric J. Kremer, Dmitry M. Shayakhmetov
Journal: Molecular Therapy (2022)

Zoonotic viruses continually pose a pandemic threat. Infection of humans with viruses for which we typically have little or no prior immunity can result in epidemics with high morbidity and mortality. These epidemics can have public health and economic impact and can exacerbate civil unrest or political instability. Changes in human behavior in the past few decades-increased global travel, farming intensification, the exotic animal trade, and the impact of global warming on animal migratory patterns, habitats, and ecosystems-contribute to the increased frequency of cross-species transmission events. Investing in the pre-clinical advancement of vaccine candidates against diverse emerging viral threats is crucial for pandemic preparedness. Replication-defective adenoviral (Ad) vectors have demonstrated their utility as an outbreak-responsive vaccine platform during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Ad vectors are easy to engineer; are amenable to rapid, inexpensive manufacturing; are relatively safe and immunogenic in humans; and, importantly, do not require specialized cold-chain storage, making them an ideal platform for equitable global distribution or stockpiling. In this review, we discuss the progress in applying Ad-based vaccines against emerging viruses and summarize their global safety profile, as reflected by their widespread geographic use during the SARS-CoV-2 pandemic.
TCT CONNECT-81 Late Outcomes After Transcatheter Aortic Valve Replacement With a Mechanically Expanded Versus Self-Expandable Valve: 4-Year Results From the REPRISE III Randomized Trial
Authors: David Rizik, Christopher Meduri, Raj Makkar, Tanvir Bajwa, Mauricio Cohen, Louis Cannon, Nicolas Van Mieghem, Robert Jobe, Howard Herrmann, Barry Cohen, Trip Zorn, John Lasala, Todd Dewey, Paul Underwood, Dominic Allocco, Michael Reardon
Journal: Journal of the American College of Cardiology (2020)
Phase I Trial of Cetuximab, Radiotherapy, and Ipilimumab in Locally Advanced Head and Neck Cancer
Authors: Robert L. Ferris, Jessica Moskovitz, Sheryl Kunning, Ayana T. Ruffin, Carly Reeder, James Ohr, William E. Gooding, Seungwon Kim, Brian J. Karlovits, Dario A.A. Vignali, Umamaheswar Duvvuri, Jonas T. Johnson, Daniel Petro, Dwight E. Heron, David A. Clump, Tullia C. Bruno, Julie E. Bauman
Journal: Clinical Cancer Research (2022)

Abstract Purpose: Concurrent radiotherapy with cetuximab, an anti-EGFR mAb, is a standard treatment for locally advanced head and neck squamous carcinoma (HNSCC). Cytotoxic T lymphocyte antigen-4–positive (CTLA-4+) regulatory T cells (Treg) dampen cellular immunity and correlate negatively with clinical outcomes. This phase I study added ipilimumab, an anti–CTLA-4 mAb, to cetuximab-radiotherapy. Patients and Methods: A (3 + 3) design was used to establish the recommended phase II dose (RP2D) of ipilimumab, added at week 5 for four, every-3-week doses to fixed, standard cetuximab-radiotherapy. Eligible subjects had stage III to IVb, high-risk [human papillomavirus–negative (HPV−)] or intermediate-risk HPV-positive (HPV+)] HNSCC. Dose-limiting toxicity (DLT) was defined as any grade 4 adverse event (AE) except in-field radiation dermatitis or immune-related (ir) AE requiring ≥2 weeks of systemic steroids. Baseline tumor and serial blood specimens were collected for immune correlatives. Results: From July 2013 to May 2016, 18 patients enrolled. Two of 6 in cohort 1 (ipilimumab 3 mg/kg) experienced grade 3 dermatologic DLTs, triggering deescalation of ipilimumab to 1 mg/kg. Dose level -1 was expanded to N = 12 without DLT. irAE included: grade 1, 2, and 3 dermatitis (2, 1, and 3 cases), grade 4 colitis (1), and grade 1 hyperthyroidism (1). Three-year disease-free survival (DFS) and overall survival were 72% [90% confidence interval (CI), 57–92] and 72% (90% CI, 56–92). High expression of coinhibitory receptors PD1/LAG3/CD39 on baseline tumor-infiltrating Treg was associated with worse DFS (HR = 5.6; 95% CI, 0.83–37.8; P = 0.08). Conclusions: The RP2D for ipilimumab plus standard cetuximab–radiotherapy is 1 mg/kg in weeks 5, 8, 11, and 14. The regimen is tolerable and yields acceptable survival without cytotoxic chemotherapy.
Comparative assessment of genes driving cancer and somatic evolution in non-cancer tissues: an update of the Network of Cancer Genes (NCG) resource
Authors: Lisa Dressler, Michele Bortolomeazzi, Mohamed Reda Keddar, Hrvoje Misetic, Giulia Sartini, Amelia Acha-Sagredo, Lucia Montorsi, Neshika Wijewardhane, Dimitra Repana, Joel Nulsen, Jacki Goldman, Marc Pollitt, Patrick Davis, Amy Strange, Karen Ambrose, Francesca D. Ciccarelli
Journal: Genome biology (2022)

Abstract Background Genetic alterations of somatic cells can drive non-malignant clone formation and promote cancer initiation. However, the link between these processes remains unclear and hampers our understanding of tissue homeostasis and cancer development. Results Here, we collect a literature-based repertoire of 3355 well-known or predicted drivers of cancer and non-cancer somatic evolution in 122 cancer types and 12 non-cancer tissues. Mapping the alterations of these genes in 7953 pan-cancer samples reveals that, despite the large size, the known compendium of drivers is still incomplete and biased towards frequently occurring coding mutations. High overlap exists between drivers of cancer and non-cancer somatic evolution, although significant differences emerge in their recurrence. We confirm and expand the unique properties of drivers and identify a core of evolutionarily conserved and essential genes whose germline variation is strongly counter-selected. Somatic alteration in even one of these genes is sufficient to drive clonal expansion but not malignant transformation. Conclusions Our study offers a comprehensive overview of our current understanding of the genetic events initiating clone expansion and cancer revealing significant gaps and biases that still need to be addressed. The compendium of cancer and non-cancer somatic drivers, their literature support, and properties are accessible in the Network of Cancer Genes and Healthy Drivers resource at http://www.network-cancer-genes.org/ .
Noncanonical HIPPO/MST Signaling via BUB3 and FOXO Drives Pulmonary Vascular Cell Growth and Survival
Authors: Tatiana V. Kudryashova, Swati Dabral, Sreenath Nayakanti, Arnab Ray, Dmitry A. Goncharov, Theodore Avolio, Yuanjun Shen, Analise Rode, Andressa Pena, Lifeng Jiang, Derek Lin, Jeffrey Baust, Timothy N. Bachman, Johannes Graumann, Clemens Ruppert, Andreas Guenther, Mario Schmoranzer, Yann Grobs, Sarah Eve Lemay, Eve Tremblay, Sandra Breuils-Bonnet, Olivier Boucherat, Ana L. Mora, Horace DeLisser, Jing Zhao, Yutong Zhao, Sébastien Bonnet, Werner Seeger, Soni S. Pullamsetti, Elena A. Goncharova
Journal: Circulation Research (2022)

The MSTs (mammalian Ste20-like kinases) 1/2 are members of the HIPPO pathway that act as growth suppressors in adult proliferative diseases. Pulmonary arterial hypertension (PAH) manifests by increased proliferation and survival of pulmonary vascular cells in small PAs, pulmonary vascular remodeling, and the rise of pulmonary arterial pressure. The role of MST1/2 in PAH is currently unknown.
Bioterrorism Alleging Use of Anthrax and Interim Guidelines for Management—United States, 1998Surveillance of Morbidity During Wildfires—Central Florida, 1998Update: Recommendations to Prevent Hepatitis B Virus Transmission—United StatesBioterrorism Alleging Use of Anthrax and Interim Guidelines for Management—United States, 1998Surveillance of Morbidity During Wildfires—Central Florida, 1998Update: Recommendations to Prevent Hepatitis B Virus Transmission—United States
Journal: JAMA (1999)