tbuckley/cabot-search huggingface dataset:
GABAkines – Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors
Authors: Rok Cerne, Arnold Lippa, Michael M. Poe, Jodi L. Smith, Xiaoming Jin, Xingjie Ping, Lalit K. Golani, James M. Cook, Jeffrey M. Witkin
Journal: Pharmacology & Therapeutics (2021)
Outcome of Therapy-Related Myeloid Neoplasms with Venetoclax-Based Therapy
Authors: Mithun V. Shah, Rakchha Chhetri, Ruchita Dholakia, Hassan B. Alkhateeb, Aref Al-Kali, Mrinal M. Patnaik, Naseema Gangat, Andrew H. Wei, Ing Soo Tiong, Kebede H. Begna, Devendra Hiwase
Journal: Blood (2021)
Association of Thrombospondin-1 Gene Polymorphism with Elevated Tricuspid Regurgitant Velocity in Sickle Cell Anemia
Authors: Parul Rai, Sara Rashkin, Victoria I Okhomina, Vijaya Joshi, Kenneth I. Ataga, Jane S Hankins, Guolian Kang, Jeremie H. Estepp
Journal: Blood (2021)
SATB1 Regulates Chromatin Organization and HSP70 Expression in Early Erythropoiesis and Is Downregulated in Models of Diamond Blackfan Anemia
Authors: Mark C Wilkes, Aya Shibuya, Vanessa M Scanlon, Hee-Don Chae, Anupama Narla, Kathleen M. Sakamoto
Journal: Blood (2021)
Impact of Temporary Percutaneous Mechanical Circulatory Support Before Transplantation in the 2018 Heart Allocation System
Authors: Kevin J. Clerkin, Oluwafeyijimi Salako, Justin A. Fried, Jan M. Griffin, Jayant Raikhelkar, Rashmi Jain, Susan Restaino, Paolo C. Colombo, Koji Takeda, Maryjane A. Farr, Gabriel Sayer, Nir Uriel, Veli K. Topkara
Journal: JACC Heart Failure (2021)
Dynamics of Cytokines Concentration in the Blood Plasma of Patients after Multipotent Mesenchymal Stromal Cells Administration for Graft Versus Host Disease Prevention
Authors: Nataliya A. Petinati, Julia O Davydova, Kseniya A. Nikiforova, Alexey Bigildeev, Georgiy Arapidi, Nina J. Drize, Larisa A. Kuzmina, Elena N. Parovichnikova, Valeriy G. Savchenko
Journal: Blood (2021)
Translational Activation of ATF4 through Mitochondrial Anaplerotic Metabolic Pathways Is Required for DLBCL Growth and Survival
Authors: Meng Li, Matthew R. Teater, Jun Young Hong, Noel R. Park, Cihangir Duy, Hao Shen, Ling Wang, Zhengming Chen, Leandro Cerchietti, Shawn M. Davidson, Hening Lin, Ari M. Melnick
Journal: Blood Cancer Discovery (2021)

Diffuse large B-cell lymphomas (DLBCL) are broadly dependent on anaplerotic metabolism regulated by mitochondrial SIRT3. Herein we find that translational upregulation of ATF4 is coupled with anaplerotic metabolism in DLBCLs due to nutrient deprivation caused by SIRT3 driving rapid flux of glutamine into the tricarboxylic acid (TCA) cycle. SIRT3 depletion led to ATF4 downregulation and cell death, which was rescued by ectopic ATF4 expression. Mechanistically, ATF4 translation is inhibited in SIRT3-deficient cells due to the increased pools of amino acids derived from compensatory autophagy and decreased glutamine consumption by the TCA cycle. Absence of ATF4 further aggravates this state through downregulation of its target genes, including genes for amino acid biosynthesis and import. Collectively, we identify a SIRT3-ATF4 axis required to maintain survival of DLBCL cells by enabling them to optimize amino acid uptake and utilization. Targeting ATF4 translation can potentiate the cytotoxic effect of SIRT3 inhibitor to DLBCL cells. SIGNIFICANCE: We discovered the link between SIRT3 and ATF4 in DLBCL cells, which connected lymphoma amino acid metabolism with ATF4 translation via metabolic stress signals. SIRT3-ATF4 axis is required in DLBCL cells regardless of subtype, which indicates a common metabolic vulnerability in DLBCLs and can serve as a therapeutic target.This article is highlighted in the In This Issue feature, p. 1.
Treatment-Free Remission (TFR) after Two Different Durations of Nilotinib Consolidation in Patients with Chronic Myeloid Leukemia (CML) Previously Treated with Imatinib: Enestpath Study Results
Authors: Delphine Rea, Slawomira Kyrcz-Krzemien, Paolo Sportoletti, Jiří Mayer, Arpad Illes, Anna Angona, Alexander Kiani, Aude Charbonnier, Theodoros Marinakis, Leif Stenke, Ansgar Weltermann, Seema Shah, Sharon Supekar, Luigi Di Caprio, Michele Baccarani
Journal: Blood (2021)
Revisiting Spleen Function and Pneumococcal Risk in Children with Hemoglobin SC Disease
Authors: Charlotte Pourdieu, Sara El Hoss, Enora Le Roux, Justine Pages, Berengere Koehl, Florence Missud, Laurent Holvoet, Ghislaine Ithier, Malika Benkerrou, Zine-Eddine Haouari, Lydie M. Da Costa, Wassim El Nemer, Yves Colin Aronovicz, Caroline Le Van Kim, Elodie Lainey, Valentine Brousse
Journal: Blood (2021)
Germline and Somatic Variants Co-Ocurrence Profile in Early Onset Adult Myelodysplastic Syndromes without a Preexisting Disorder
Authors: Tzu Hua Chen-Liang, Salvador Carrillo-Tornel, Marta Santiago, Bernardo López Andrade, Francisca Maria Hernandez, Paloma García-Martín, Félix López Cadenas, Mar Tormo, María Lourdes Hermosín, Teresa Bernal del Castillo, Esperanza Tuset, Ángeles Medina Perez, Helena Pomares, Teresa Arquero, María Julia Montoro, Blanca Xicoy, Francesc Solé, Guillermo Sanz, David Valcarcel, Maria Diez-Campelo, Andres Jerez
Journal: Blood (2021)
The Clinical Course and Life Expectancy of Patients with Multiple Myeloma Who Discontinue Their First Daratumumab-Containing Line of Therapy
Authors: Agoston Gyula Szabo, Jonathan Thorsen, Katrine Fladeland Iversen, Mette Bøegh Levring, Birgitte Preiss, Carsten Helleberg, Marie Fredslund Breinholt, Emil Hermansen, Lise Mette Rahbek Gjerdrum, Søren Bønløkke, Katrine Nielsen, Eigil Kjeldsen, Manuela Teodorescu, Marveh Dokhi, Eva Kurt, Casper Noergaard Strandholdt, Mette Klarskov Andersen, Annette J. Vangsted
Journal: Blood (2021)
International federation of genomic medicine databases using GA4GH standards
Authors: Adrian Thorogood, Heidi L. Rehm, Peter Goodhand, Angela J.H. Page, Yann Joly, Michael Baudis, Jordi Rambla, Arcadi Navarro, Tommi H. Nyronen, Mikael Linden, Edward S. Dove, Marc Fiume, Michael Brudno, Melissa S. Cline, Ewan Birney
Journal: Cell Genomics (2021)

We promote a shared vision and guide for how and when to federate genomic and health-related data sharing, enabling connections and insights across independent, secure databases. The GA4GH encourages a federated approach wherein data providers have the mandate and resources to share, but where data cannot move for legal or technical reasons. We recommend a federated approach to connect national genomics initiatives into a global network and precision medicine resource.
Phase I Study of FT516, an Off-the-Shelf iPSC-Derived NK Cell Therapy, in Combination with Rituximab in Patients with Relapsed/Refractory B-Cell Lymphoma
Authors: Krish Patel, Veronika Bachanova, Aaron M Goodman, John M. Pagel, Kelly Griffis, Marlisa Anderson, Siminder Atwal, Cara Bickers, Peter Szabo, Lilly Wong, Yu-Waye Chu, Rebecca Elstrom, Paolo Strati
Journal: Blood (2021)
Letter to the editor: “Autoimmune hepatitis after COVID‐19 vaccination”
Authors: Rujittika Mungmunpuntipantip, Viroj Wiwanitkit
Journal: Hepatology (2021)

To the editor, We would like to correspond on the issue of autoimmune hepatitis (AIH) following COVID‐19 vaccination.[1] Palla et al. discuss the possible association between AIH and COVID‐19 vaccination.[1] Adverse effects of the vaccine are possible, and liver problems following vaccination present an interesting clinical problem. Some researchers propose that an abnormal immune response is the definitive cause of AIH.[2] However, it is usually hard to definitively state that AIH is induced by a vaccine. Almost all reported cases lack prevaccination laboratory data, and it is not possible to exclude the existence of prevaccination autoimmunity. Also, there is usually no complete investigation for other causes of hepatitis. Additionally, the AIH might be a coincidence. Coincidence of a medical problem after COVID‐19 vaccination and differential diagnosis is hard. For example, dengue can co‐occur in a vaccine recipient and cause platelet and liver problems.[3] After vaccination, there is also the possibility of excessive blood viscosity,[4] which might also be a trigger factor for liver problems.[5] CONFLICT OF INTEREST Nothing to report.
The Fifth-Generation Cardiac Troponin T and Cardiovascular Disease in the Community
Authors: Yasuyuki Honda, Yejin Mok, Junichi Ishigami, Kellan E. Ashley, Ron C. Hoogeveen, Christie M. Ballantyne, Amy B. Karger, David Couper, Elizabeth Selvin, Kunihiro Matsushita
Journal: Journal of the American College of Cardiology (2021)
Abemaciclib in Combination with Copanlisib to Overcome Therapeutic Resistance in Mantle Cell Lymphoma
Authors: Yuxuan Che, Yang Liu, Yijing Li, Joseph McIntosh, Alexa A Jordan, Zhihong Chen, Fangfang Yan, Wei Wang, Jingling Jin, Changying Jiang, Yixin Yao, Michael Wang
Journal: Blood (2021)
Multiple <i>TET2</i> Mutations As a New Biological Clue for Differentiating Oligomonocytic Chronic Myelomonocytic Leukemia from Myelodysplastic Syndromes
Authors: Nieves Garcia-Gisbert, Leonor Arenillas, David Roman-Bravo, Juan José Rodríguez-Sevilla, Brayan Merchan, Sara Garcia-Avila, Concepción Fernández-Rodríguez, Joan Gibert, Antonio Salar, Beatriz Bellosillo, Ana Ferrer, Xavier Calvo
Journal: Blood (2021)
Carfilzomib Is Safe in Elderly Patients with Multiple Myeloma but Thrombotic Microangiopathy Is Underestimated in Clinical Practice
Authors: Toshiki Terao, Takafumi Tsushima, Daisuke Miura, Daisuke Ikeda, Ami Fukumoto, Ayumi Kuzume, Rikako Tabata, Kentaro Narita, Masami Takeuchi, Kosei Matsue
Journal: Blood (2021)
Automated Analysis of Doppler Echocardiographic Videos as a Screening Tool for Valvular Heart Diseases
Authors: Feifei Yang, Xiaotian Chen, Xixiang Lin, Xu Chen, Wenjun Wang, Bohan Liu, Yao Li, Haitao Pu, Liwei Zhang, Dangsheng Huang, Meiqing Zhang, Xin Li, Hui Wang, Yueheng Wang, Huayuan Guo, Yujiao Deng, Lu Zhang, Qin Zhong, Zongren Li, Liheng Yu, Yongjie Duan, Peifang Zhang, Zhenzhou Wu, Daniel Burkhoff, Qiushuang Wang, Kunlun He
Journal: JACC. Cardiovascular imaging (2021)
Safety, Tolerability, and Clinical Pharmacology of ANX009, an Inhibitory Antibody Fab Fragment Against C1q, Administered Subcutaneously to Healthy Volunteers
Authors: Anita Grover, Jeffrey Teigler, Emily Radomile, Shawn Rose, Ted Yednock, Sanjay Keswani, Henk-Andre Kroon
Journal: Blood (2021)
Comparison of Myeloablative Versus Reduced-Intensity Fludarabine/Busulfan Regimen in Patients with Myelodysplastic Syndrome Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
Authors: Shuhei Kurosawa, Yoshimitsu Shimomura, Hidehiro Itonaga, Yuho Najima, Takeshi Kobayashi, Yukiyasu Ozawa, Yoshinobu Kanda, Shinichi Kako, Toshiro Kawakita, Ken-Ichi Matsuoka, Yumiko Maruyama, Shuichi Ota, Hideyuki Nakazawa, Kazunori Imada, Takafumi Kimura, Junya Kanda, Takahiro Fukuda, Yoshiko Atsuta, Ken Ishiyama
Journal: Blood (2021)
Abstract 12429: What is the Clinical Impact of Echocardiography Among Hospitalized Patients With Prior Testing?
Authors: Abdullah Pervaiz, Anis John Kadado, Kyle Gobeil, Ritika Walia, Petal Elder, Ayman Battisha, Saima Shikari, Tara Lagu, William L Hiser, Quinn Pack
Journal: Circulation (2021)

Introduction: The versatility and safety of transthoracic echocardiography (TTE) has made it one of the most frequently ordered cardiac imaging tests. However, for inpatients with prior TTE results, the clinical impact of repeat TTE remains uncertain. Methods: We evaluated the charts of sequential hospitalized patients with prior TTE results who underwent an inpatient TTE. We noted prior and current TTE results, if imaging findings were abnormal [(using definitions from Hua (Echocardiography, 2017)], and if these findings were significantly different between the studies. We then evaluated all records for changes in clinical management, including medication changes, additional diagnostic testing, new specialty consultation, or invasive procedures. We used a multivariable model to determine predictors of changes in clinical management. Results: Of 229 sequential patients who underwent an inpatient TTE [median age 71, 55% male, 90% white, 67% abnormal prior TTE], most met Appropriate Use Criteria (92%), most were abnormal (80%), and most changed in at least one aspect from the prior study (66%). However, despite the majority of repeat TTEs with new changes, clinical management was impacted in only a minority of cases 61 (27%). Of these, 27 (12%) resulted in medication changes; 15 (6%) had further diagnostic testing; 14 (6%) had a new specialty consultation; and 11 (4%) had invasive procedures ordered (cardiac catheterization, pericardial drain placement, and cardiac surgery). After adjusting for ordering provider, race of patient, and study indication, new findings on the TTE predicted changes in clinical management OR 4.2, p&lt;0.001). Conclusion: Despite the large majority of repeat TTE’s meeting AUC guidelines, being abnormal, and having imaging changes, repeat TTE infrequently impacted clinical management. Although new TTE abnormalities are associated with clinical management changes in some cases, the clinical value of repeat TTE in the setting of prior imaging results may be lower than most clinicians assume. Efforts to identify the population for whom TTE studies are most likely to impact clinical care would increase the clinical yield of repeat TTE.
Novel Agents May be Preferable to Chemotherapy for Large B-Cell Lymphoma Progressing after CD19-CAR-T: A Multicenter Observational Study
Authors: Ana Alarcon Tomas, Joshua A Fein, Shalev Fried, Warren Fingrut, Theodora Anagnostou, Anna Alperovich, Nishi Shah, Ellen Fraint, Richard J Lin, Michael Scordo, Aishat Olaide Afuye, Connie Lee Batlevi, Michal Besser, Parastoo B Dahi, Ivetta Danylesko, Sergio Giralt, Brandon S. Imber, Elad Jacobi, Arnon Nagler, M. Lia Palomba, Gilles Salles, Craig S. Sauter, Gunjan L Shah, Noga Shem-Tov, Avichai Shimoni, Joachim Yahalom, Ronit Yerushalmi, Abraham Avigdor, Miguel-Angel Perales, Roni Shouval
Journal: Blood (2021)
Combination Venetoclax and Selinexor Effective in Relapsed/Refractory Multiple Myeloma with Translocation t(11;14)
Authors: Nina Nguyen, Sana Chaudhry, Tulasigeri M Totiger, Skye Montoya, Jumana Afaghani, Terrence Bradley, Francesco Maura, Dickran Kazandjian, Jennifer R Chapman, Ola Landgren, James E. Hoffman, Justin Taylor
Journal: Blood (2021)
Abstract 9201: Association Between Remnant Cholesterol, High-Sensitivity C-reactive Protein, and Risk of Atherosclerotic Cardiovascular Disease Events in the Multi-ethnic Study of Atherosclerosis (MESA)
Authors: Parag A Chevli, Tareq Islam, Yashashwi Pokharel, Fatima Rodriguez, Salim S Virani, Michael J Blaha, Alain G Bertoni, Matthew Budoff, James D Otvos, Michael D Shapiro
Journal: Circulation (2021)

Background: Elevated remnant-like particle (RLP)-cholesterol (RLP-C) and high-sensitivity C-reactive protein (hsCRP) are each associated with atherosclerotic cardiovascular disease (ASCVD) individually. Whether a serum marker of systemic inflammation modifies RLP-C associated ASCVD risk is unknown. The purpose of this study was to evaluate the interplay of nuclear magnetic resonance (NMR)-derived RLP-C and hsCRP and their association with ASCVD risk in the Multi-Ethnic Study of Atherosclerosis (MESA). Methods: Lipoprotein particles were measured using NMR spectroscopic analysis among MESA participants. RLP-C includes very-low-density lipoprotein (VLDL)-cholesterol and intermediate-density lipoprotein (IDL)-cholesterol. Four groups were created as follows: Group 1: RLP-C ≤ median (≤29.14 mg/dL) and hsCRP &lt; 2 mg/dL; Group 2: RLP-C ≤ median (≤29.14 mg/dL) and hsCRP≥ 2 mg/dL; Group 3: RLP-C &gt; median (&gt;29.14 mg/dL) and hsCRP level &lt; 2 mg/dL; and Group 4: RLP-C &gt; median (&gt;29.14 mg/dL) and hsCRP level ≥ 2 mg/dL. Kaplan-Meier survival curves and multivariable adjusted Cox proportional hazard models were used to examine the relationship between RLP-C and hsCRP with incident ASCVD. Results: A total of 6,720 MESA participants (mean age 62.2 y, SD 10.2, 53% female) who had baseline NMR-derived RLP-C and hsCRP measurements were included. At a median follow-up of 15.6 years, a total of 1,032 ASCVD events were observed. In the fully adjusted model, compared to those in the reference group (Group 1), participants in Group 2, Group 3, and Group 4 demonstrated a 24% (95%CI, 1.02 - 1.50), 22% (1.01 - 1.46), and 47% (1.22 - 1.77) increased risk of incident ASCVD events, respectively (p &lt;0.001). Conclusion: We found an independent association of NMR-derived RLP-C and hsCRP with incident ASCVD in an ethnically and geographically diverse population. Notably, the combination of increased RLP-C and hsCRP was associated with a markedly increased risk of future ASCVD events.
Sars-Cov-2 Infection Associated with Aplastic Anemia and Pure Red Cell Aplasia
Authors: Nicholas C.J. Lee, Bhavisha A. Patel, Taha Bat, Ibrahim F. Ibrahim, Madhuri Vusirikala, Mingyi Chen, Flavia G Rosado, Jesse Jaso, Neal S. Young, Weina Chen
Journal: Blood (2021)
Bivalent Histone Modifications By Reiibp Leads to Transcriptional Reprogramming and TLR7-BTK Driven IL-6 Pro-Inflammatory Response in t(4;14) Myelomagenesis
Authors: Phyllis SY Chong, Julia Lim, Jing Yuan Chooi, Wee-Joo Chng
Journal: Blood (2021)
Abstract 9008: Echocardiographic Markers in Early Postnatal Life to Predict Intervention in Coarctation of Aorta
Authors: Punnanee Wutthigate, Jessica Simoneau, Claudia Renaud, Gabriel Altit
Journal: Circulation (2021)

Background: Coarctation of the aorta (CoA) is challenging to diagnose in the early neonatal life due to the patent ductus arteriosus (PDA). We aimed to describe the resource utilization, early post-natal cardiac profile and predictors for need of cardiac surgery. Methods: Retrospective study of infants with an antenatal suspicion of CoA, without major associated cardiac anomalies, born at ≥37 weeks during 2014 to 2020. The analyzed echocardiography (ECHO) was performed within 48 hours after birth. Those not requiring post-natal intervention (normal group) were compared to those that required post-natal cardiac surgery (CoA). Strain was measured using speckle-tracking ECHO (STE). Results: A total of 51 newborns were included, of which 40 (78%) were normal and 11 (22%) underwent intervention. In the normal group, median hospitalization was 4 [2-6] days, 6 (15%) were exposed to prostaglandin E (PGE) infusion, 38 (95%) were on intravenous fluids, 9 (23%) required gavage and age at full feeds was 3 days (IQR: 2-5). Ductus was patent in all newborns and aortic arch measurements were significantly smaller in the CoA (ascending [p=0.01], proximal, distal, isthmus [ p &lt;0.001]). Right ventricular (RV) predominance was higher in the CoA group, as demonstrated by the left ventricular (LV) end-systolic eccentricity index (EI) (1.60 [0.28] vs 2.16 [0.45]; p &lt;0.001) and by a larger end-diastolic area (EDA) of the RV in apical 4 chamber (A4C) relative to the LV-EDA - with a ratio of 1.02 [0.2] vs 1.56 [0.23]; p &lt;0.001. Isthmus and EI were predictive for intervention (OR 26, 95%CI (-42 to -9); p =0.002, OR 4.5, 95%CI (1.5-7.5); p =0.003). A RV to LV EDA ratio in A4C greater than 1.3 demonstrated a high probability for intervention (AUC = 0.97). CoA newborns had a lower RV deformation by STE (peak systolic strain rate (SR); -0.98 [0.17] vs -0.83 [0.2]; p =0.02, early diastolic SR; 1.05 [0.2] vs 0.85 [0.26]; p =0.01). Conclusions: Most infants with antenatal suspicion of CoA did not require intervention but were high consumers of resources. Despite PDA patency, isthmus and RV predominance on first post-natal ECHO were predictors for surgery. The novel markers of strain by STE and ventricular EDA ratio in A4C may help predicting those with true CoA requiring intervention.
Thunderstorm asthma in seasonal allergic rhinitis: The TAISAR study
Authors: Jo A. Douglass, Caroline Lodge, Samantha Chan, Alice Doherty, Ju Ann Tan, Celina Jin, Alastair Stewart, Anne M. Southcott, Andrew Gillman, Joy Lee, Danny Csutoros, Liam Hannan, Laurence Ruane, Sara Barnes, Lou Irving, Nur-Shirin Harun, Phillipe Lachapelle, Kymble Spriggs, Michael Sutherland, Katharine See, Christine F. McDonald, Matthew Conron, Naghmeh Radhakrishna, Christopher Worsnop, Fay H. Johnston, Janet M. Davies, Vanessa Bryant, Linda Iles, David Ranson, Paresa Spanos, Don Vicendese, Adrian Lowe, Edward J. Newbigin, Philip Bardin, Shyamali Dharmage
Journal: Journal of Allergy and Clinical Immunology (2021)
Health inequities and the inappropriate use of race in nephrology
Authors: Nwamaka D. Eneanya, L. Ebony Boulware, Jennifer Tsai, Marino A. Bruce, Chandra L. Ford, Christina Harris, Leo S. Morales, Michael J. Ryan, Peter P. Reese, Roland J. Thorpe, Michelle Morse, Valencia Walker, Fatiu A. Arogundade, Antonio A. Lopes, Keith C. Norris
Journal: Nature Reviews Nephrology (2021)
Long-Term Survival after Intensive Chemotherapy or Hypomethylating Agents in AML Patients Aged 70 Years and Older: A Large Patient Data Set Study from Dataml, SAL and Pethema European Registries
Authors: Christian Recher, Christoph Rollig, Emilie Berard, Sarah Bertoli, Pierre-Yves Dumas, Suzanne Tavitian, Hubert Serve, Martin Bornhäuser, Uwe Platzbecker, Carsten Müller-Tidow, Claudia D. Baldus, David Martínez-Cuadrón, Josefina Serrano, Pilar Martínez, Eduardo Rodríguez-Arbolí, Cristina Gil, Juan-Miguel Bergua, Teresa Bernal, Adolfo de la Fuente, Eric Delabesse, Audrey Bidet, Arnaud Pigneux, Pau Montesinos, Michael Kramer
Journal: Blood (2021)
A Novel Bispecific T Cell Engager (UMG2-BTCE) Targeting CD1a-CD3ε Is Effective Against Cortical-Derived Acute Lymphoblastic Leukemia
Authors: Caterina Riillo, Daniele Caracciolo, Katia Grillone, Nicoletta Polerà, Giada Juli, Francesca Scionti, Serena Ascrizzi, Franca Maria Tuccillo, Patrizia Bonelli, Mariamena Arbitrio, Maria Teresa Di Martino, Pierosandro Tagliaferri, Pierfrancesco Tassone
Journal: Blood (2021)
Changes in CMR Parameters and Prediction of Cardiac Complications in Thalassemia Major: Fibrosis Tells Us More Than Iron
Authors: Alessia Pepe, Laura Pistoia, Pietro Giuliano, Nicola Giunta, Rosamaria Rosso, Alessandra Quota, Silvia Macchi, Aurelio Maggio, Giacomo Agliata, Stefania Renne, Vincenzo Positano, Antonella Meloni
Journal: Blood (2021)
Half: A Prospective Multi-Centre Phase II Clinical Trial Evaluating the Efficacy and Safety of Tyrosine Kinase Inhibitors' Discontinuation after Two-Step Dose Reduction in Patients with Chronic Myeloid Leukemia in Deep Molecular Remission
Authors: Daniela Žácková, Edgar Faber, Lukáš Stejskal, Michal Karas, Petra Bělohlávková, Hana Klamová, Olga Černá, Eduard Cmunt, Petra Čičátková, Lukáš Semerád, Tomáš Horňák, Anežka Kvetková, Jiřina Procházková, Jitka Rychlíčková, Radka Štěpánová, Adam Svobodník, Kateřina Machová Poláková, Ivana Ježíšková, Tomáš Jurček, Marek Borský, Ondřej Wiewiorka, Regina Demlová, Jiří Mayer
Journal: Blood (2021)
PRMT5 Inhibition Promotes FOXO1 Tumor Suppressor Activity to Drive a Pro-Apoptotic Program That Creates Vulnerability to Combination Treatment with Venetoclax in Mantle Cell Lymphoma
Authors: Fiona Brown, Inah Hwang, Shelby Sloan, Claire Hinterschied, JoBeth Helmig-Mason, Mackenzie Long, Youssef Youssef, Wing Keung Chan, Alexander Prouty, Ji Hyun Chung, Yang Zhang, Kris Vaddi, Selina Chen-Kiang, Maurizio Di Liberto, Olivier Elemento, Lalit Sehgal, Lapo Alinari, Peggy Scherle, Rosa Lapalombella, Jihye Paik, Robert Baiocchi
Journal: Blood (2021)