POS1422 CORRELATES OF TESTING POSITIVE FOR SARS-COV-2 IN PATIENTS WITH RHEUMATIC AD MUSCULOSKELETAL DISEASES
Authors: N. Singh, I. Huang, M. Singleton, A. Bays, J. Sabo, S. Chung, G. Gardner, J. Schaeffer, K. Wysham, J. Andrews, R. Patel, J. Simard, J. Liew
Journal: Annals of the Rheumatic Diseases (2021)

Background: Many studies on COVID-19 outcomes in patients with RMD have either restricted to COVID positive RMD patients or compared them to the general clinic population as a comparator. Given heterogeneity in behaviors and risks, clinical characteristics associated with a positive diagnosis among patients with RMD seeking testing for Sars-CoV-2 remain less well studied. Objectives: Among patients with RMD receiving a Sars-CoV-2 PCR test, we aimed to identify RMD-related factors associated with a positive test result. Methods: Among patients seen at least once in the University of Washington (UW) rheumatology clinics between March 2018 to March 2020, we reviewed electronic medical records to identify patients undergoing Sars-CoV-2 PCR testing from March 1 through October 31, 2020. Patients with RMD were categorized into two groups: those who tested positive for Sars-CoV-2 and those who tested negative. We randomly selected patients from the negative group in a 2:1 ratio for further data abstraction. Student’s t -test and Chi-squared tests were used to compare continuous and categorical variables, respectively, between the groups. To determine the correlates of testing positive for Sars-CoV-2, specifically RMD medication use and disease activity, we constructed different multivariable logistic regression models adjusted for age, sex, race/ethnicity, presence of comorbidities, body mass index, and smoking. Results: A total of 2768 RMD patients underwent SARS-CoV-2 PCR testing within the UW system, of whom 43 (1.5%) were positive at least once. Three patients with incomplete information were excluded. Patients who tested positive had higher prevalence of end stage renal disease (ESRD)/chronic kidney disease (CKD) (24% versus 11%), had higher rates of active disease (24% versus 20%), were older (&gt;55 years) (mean age 57.3 versus 54.8 years), male (63% versus 55%), non-white race/ethnicity (32% versus 26%), and higher prevalence of multiple comorbidities (42% versus 31%) (Table 1). In the multivariable models, neither RMD medication use (versus no use, Table 1) nor high disease activity (vs low disease activity/remission) were statistically significantly associated with COVID-19 positivity. Among the 41 COVID-19 positive patients, a majority recovered without specific treatments, although approximately one third of the positive patients were hospitalized and three deaths were observed. Conclusion: In this study, patients who tested positive did not differ in many ways from those who tested negative. Table 1. Baseline characteristics of the patients prior to COVID testing Variables All (N=126 ) COVID Positive (N=41 ) COVID Negative (N=85 ) P value Age in years – mean (SD) 55.6 (15.3) 57.3 (16.3) 54.8 (14.9) 0.40 Sex 0.39 Male 73 (57.9) 26 (63.4) 47 (55.3) Female 53 (42.1) 15 (36.6) 38 (44.7) Race 0.39 White 89 (71.2) 26 (63.4) 63 (74.1) Other race 35 (28.2) 13 (31.7) 22 (25.9) Missing 2 (1.6) 2 (4.9) 0 (0.0) Rheumatic disease 0.64 OA/Crystal/Fibromyalgia 37 (29.4) 11 (26.8) 26 (30.6) RA/SpA 32 (25.4) 9 (22.0) 23 (27.1) All others 57 (45.2) 21 (51.2) 36 (42.3) Rheumatic disease activity 0.57 Active 27 (21.4) 10 (24.4) 17 (20.0) Not active 99 (78.6) 31 (75.6) 68 (80.0) Co-morbidities Diabetes mellitus (%) 25 (19.8) 9 (22.0) 16 (18.8) 0.68 Hypertension 48 (38.1) 20 (48.8) 28 (32.9) 0.09 Cardiovascular disease 23 (18.3) 9 (22.0) 14 (16.5) 0.46 Lung disease 25 (19.8) 10 (24.4) 15 (17.7) 0.37 Cancer 10 (7.9) 3 (7.3) 7 (8.2) 0.86 ESRD/CKD 19 (15.1) 10 (24.4) 9 (10.6) 0.04* BMI: Body mass index; SD: Standard deviation; OA: Osteoarthritis; Crystal: Crystalline diseases; RA: Rheumatoid arthritis; SpA: Spondyloarthritis Acknowledgements: The work in this study was supported by grant UL1 TR002319 to Dr Singh from the Institute of Translational Health Sciences of the University of Washington. Disclosure of Interests: None declared