tbuckley/cabot-search huggingface dataset:
Venous flow velocity, venous volume and arterial blood flow.
Authors: J DCoffman, J ALempert
Journal: Circulation (1975)

The relationship of arterial blood flow and venous volume to venous flow velocity was studied in normal subjects. The effects of current modes of treatment in venous thrombosis and of a vasodilator drug on venous flow velocity were also investigated. Total calf flow and venous volume were measured by venous occlusion plethysmography while venous flow axial velocity was determined by the transit time of 131-I albumin from calf to inguinal region. Local intravenous epinephrine administration induced venoconstriction and increased venous flow velocity. Intra-arterial isoproterenol and angiotensin increased and decreased arterial flow, respectively, with no change in venous flow velocity of volume, but local heat increased arterial flow and venous flow velocity with no change in venous volume. Local cold, despite venoconstriction, decreased venous flow velocity accompanied by a decreased arterial flow. Intravenous heparin did not affect venous flow velocity. Intravenous but not oral nylidrin increased venous ...
Regional entrainment of atrial fibrillation studied by high-resolution mapping in open-chest dogs.
Authors: CKirchhof, FChorro, G JScheffer, JBrugada, KKonings, ZZetelaki, MAllessie
Journal: Circulation (1993)

BACKGROUNDIt recently has been demonstrated that during atrial fibrillation, a short and variable excitable gap exists, allowing regional control of atrial fibrillation by local stimulation. In the present study, we visualized the process of excitation during regional entrainment of atrial fibrillation by rapid pacing.METHODS AND RESULTSIn six open-chest dogs, the excitation of the left atrial free wall was mapped using a spoon-shaped mapping electrode (248 points). Episodes of atrial fibrillation were induced by burst pacing (50 Hz, 2 seconds). During atrial fibrillation, the electrograms showed rapid irregular activity with a median cycle length of 98 +/- 16 ms (mean +/- SD, n = 6). Rapid pacing in the center of the mapping electrode at intervals slightly shorter or longer than the median atrial fibrillation interval resulted in regional capture of atrial fibrillation. The window of entrainment was 16 +/- 5 ms. Mapping of atrial fibrillation showed that the left atrium was activated by fibrillatory wave...
Cardiovascular manifestations of mixed connective tissue disease in adults.
Authors: M AAlpert, S HGoldberg, B HSingsen, J BDurham, G CSharp, MAhmad, N PMadigan, D PHurst, W DSullivan
Journal: Circulation (1983)

To assess the nature and distribution of cardiovascular abnormalities associated with mixed connective tissue disease, we studied 38 patients with overlapping clinical manifestations of systemic lupus erythematosus, progressive systemic sclerosis and polymyositis, and circulating antibodies to nuclear ribonucleoprotein. The protocol included taking a medical history and a physical echocardiogram, and pulmonary function tests. Cardiac catheterization was performed on 17 patients. Postmortem examination was performed on four of the five patients who died during follow-up. Acute pericarditis and/or pericardial effusion was detected in 11 patients (29%) and mitral valve prolapse was identified in 10 patients (26%). Marked intimal hyperplasia of coronary arteries was observed in all four hearts that were autopsied and perivascular and myocardial leukocytic aggregates were present in two hearts. Pulmonary vascular resistance was elevated in 11 of the 17 patients who underwent cardiac catheterization. In summary...
Abstract 11164: Atrioventricular Conduction Disease Associated With Ticagrelor Use in Acute Coronary Syndrome
Authors: Karim Abdur Rehman, Haris Riaz, Mina K Chung, Grant Reed
Journal: Circulation (2019)

Introduction: Ticagrelor inhibits cellular uptake of adenosine and increases its plasma concentration which may cause an atrioventricular (AV) blocking effect. Case: A 55 year old male with history...
Cardiotoxicity of human recombinant interleukin-2 in rats. A morphological study.
Authors: JZhang, Z XYu, S LHilbert, MYamaguchi, D PChadwick, E HHerman, V JFerrans
Journal: Circulation (1993)

BACKGROUNDOne of the side effects of interleukin 2 (IL-2) cancer immunotherapy in humans is the vascular leak syndrome, which is frequently associated with depression of myocardial function, myocarditis, and myocardial necrosis.METHODS AND RESULTSTo investigate this cardiotoxicity, IL-2 (three doses of 5 x 10(5) Cetus units/day i.p.) was given to rats for 2, 3, or 5 days. Heart, lung, liver, spleen, and kidney tissues were studied by light and electron microscopy and with immunoperoxidase techniques. Cardiac changes consisted of focal lymphocytic and eosinophilic infiltration, myocyte vacuolization, myofibrillar loss, and necrosis. Ultrastructural alterations included swelling of endothelial cells, with dissociation of intercellular junctions, migration of lymphocytes into the interstitium, and interstitial hemorrhage and edema. Close contact between infiltrating lymphocytes, particularly large granular lymphocytes, and cardiac myocytes was often observed in areas of tissue damage. All lesions were more s...
Abstract 12254: The Long-term Mortality and Severe Complication Rate Are Similar in Patients 85 Years Old or Over and Younger Patients
Authors: Yasuhiro Matsuda, Masaharu Masuda, Mitsutoshi Asai, Osamu Iida, Shin Okamoto, Takayuki Ishihara, Kiyonori Nanto, Takashi Kanda, Takuya Tsujimura, Shota Okuno, Hiroyuki Uematsu, Yuki Sato, Shodai Kawanami, Hiroki Sugae, Sho Nakao, Toshiaki Mano
Journal: Circulation (2019)

Introduction: Many elderly patients need pacemaker implantation. However, there are a lot of comorbidities and increased frailty in older patients, and physicians often hesitate to implant pacemake...
Measurement of cardioversion/defibrillation thresholds in man by a truncated exponential waveform and an apical patch-superior vena caval spring electrode configuration.
Authors: R AWinkle, E BStinson, S MBach, D SEcht, POyer, KArmstrong
Journal: Circulation (1984)

Defibrillation/cardioversion thresholds were measured in 33 patients undergoing defibrillator implants. Each patient had a 12 cm2 patch placed near the left ventricular apex via a thoracotomy and a 10 cm2 spring lead placed pervenously at the right atrial-superior vena caval junction. Ventricular tachycardia of stable morphology, polymorphic ventricular tachycardia, or ventricular fibrillation was induced four times in each patient and 1, 5, 10, and 25 J truncated exponential shocks with 60% tilt were given in a random sequence. The conversion rate was constant (77%, 86%, 87%, 85%) with increasing energy for ventricular tachycardia but progressively increased for polymorphic ventricular tachycardia and ventricular fibrillation (8%, 33%, 58%, 92%). The ventricular tachycardia acceleration rates for 1, 5, 10, and 25 J were 23%, 14%, 10%, and 15%. Patients not reliably converted with 25 J may require repositioning of leads or two patches. We conclude that for the spring-patch electrodes, increasing energy fr...
The influence of pressure overload left ventricular hypertrophy on diastolic properties during hypoxia in isovolumically contracting rat hearts.
Authors: B HLorell, L FWexler, SMomomura, EWeinberg, C SApstein
Journal: Circulation Research (1986)

We tested the hypothesis that there is an enhanced susceptibility in hypertrophied cardiac muscle to develop decreased diastolic distensibility of the left ventricle in response to hypoxia. The effects of brief hypoxia (3 minutes) were studied in rats with and without chronic left ventricular pressure overload hypertrophy using an isolated buffer-perfused and isovolumic (balloon-in-left ventricle) heart preparation with excised pericardium and vented right ventricle. We compared hypertrophied hearts from hearts from hypertensive uninephrectomized Wistar-Kyoto rats (n = 12) with normotensive uninephrectomized age-matched controls (n = 13). Coronary flow was held constant and adjusted so that an identical flow per gram left ventricular weight was achieved in both groups. The left ventricular balloon volume was adjusted to produce an initial left ventricular end-diastolic pressure of 10 mm Hg in both groups and was held constant thereafter so that changes in left ventricular end-diastolic pressure during hyp...
The asymmetrically hypertrophied septum. Further differentiation of its causes.
Authors: W ELarter, H DAllen, D JSahn, S JGoldberg
Journal: Circulation (1976)

Fifty-eight subjects with echocardiographic criteria for an abnormal septal to left ventricular posterior wall ratio were studied. Echocardiographic findings were related to clinical cardiac status. Abnormal ratios were found in normal children and in children with a variety of cardiac lesions, only one of which was obstructive or non-obstructive cardiomyopathy. In those without cardiomyopathy, the abnormal ratio usually resolved by one or two years of age. Persistence of abnormal ratio usually occurred in patients with increased right ventricular anterior wall thickness or idiopathic hypertrophic subaortic stenosis. The cause of abnormal ratio is multifactorial.
Role of adenosine in coronary blood flow regulation after reductions in perfusion pressure.
Authors: W PDole, NYamada, V SBishop, R AOlsson
Journal: Circulation Research (1985)

We employed intracoronary infusion of adenosine deaminase to test the hypothesis that endogenous adenosine contributes to regulation of coronary blood flow following acute reductions in coronary artery pressure. In 16 closed-chest anesthetized dogs, we perfused the left circumflex coronary artery from a pressurized arterial reservoir and measured coronary blood flow following changes in perfusion pressure before and 10 minutes after the start of intracoronary adenosine deaminase, 5 U/min per kg body weight. Parallel studies showed that this dose of enzyme resulted in cardiac lymph adenosine deaminase concentrations of 3.2 +/- 0.4 U/ml. Adenosine deaminase abolished the vasodilator response to intracoronary adenosine, 4 and 8 micrograms, but had no effect on the vasodilator response to intracoronary papaverine, 200 and 300 micrograms, demonstrating enzyme efficacy and specificity. Additional experiments demonstrated that adenosine deaminase reversibly attenuated myocardial reactive hyperemia following 5- a...
The elderly patient with severe arterial insufficiency of the lower extremity: limb salvage by femoro-popliteal reconstruction.
Authors: F AReichle, K PRankin, R RTyson, C RShuman, A JFinestone
Journal: Circulation (1979)

To determine the feasibility of limb salvage in elderly patients in whom severe ischemia of the lower extremity is present, the results of femoro-popliteal reconstruction done primarily for limb salvage were reviewed. Of 310 femoro-popliteal bypasses, 72 were performed on patients 70 years of age or older. In the over-70 group, ischemic necrosis was present in 70.8% rest pain in 22.2%, and claudication in 7.0%. Initial limb salvage patients 70 years of age or older was 71.4%. Cumulative limb salvage at 5 years was 51.1% and at 10 years was 44.8%. Operative mortality, including mortality of subsequent amputation, when required, was 8.3%. Appreciable limb salvage can be achieved by femoro-popliteal arterial reconstruction in lieu of primary amputation in elderly patients in whom severe arterial insufficiency of the lower extremity is present.
Endoscopic Treatment of Biliopancreatic Pathology In Patients With Previous Whipple’S Duodenopancreatectomy: Lessons Learned From Single-Balloon Enteroscopy-Assisted ERCP
Authors: R Garcés-Duran, L Monino, P Deprez, H Piessevaux, T Moreels
Journal: Endoscopy (2021)

Aims Endoscopic treatment of subsequent biliopancreatic pathology is challenging due to altered anatomy in Whipple’s duodenopancreatectomy. To evaluate feasibility and safety of single-balloon enteroscopy-assisted ERCP (SBE-ERCP) to treat biliary and/or pancreatic pathology after Whipple’s duodenopancreatectomy.
Well Differentiated Gastric Adenocarcinoma on the Base of Pyloric Gland Adenoma
Authors: R Kuvaev, E Kraynova, M Vieth, S Kashin, K Yao, T Yao
Journal: Endoscopy (2021)

A 64-year-old woman was referred to our hospital for further examination of a gastric lesion. Esophagogastroduodenoscopy revealed a 30-mm elevated lesion of gastric body with whitish irregular surface. Magnifying narrow-band imaging indicated slightly irregular polygonal microvessels located in enlarged intervening part between crypts and surrounded by widened marginal crypt epithelium. According to VS classification, the lesion had irregular MV pattern plus irregular MS pattern with a demarcation line. Helicobacter pylori was not detected. ESD was performed for en bloc resection of the lesion. Histological examination of the post-ESD specimen showed well differentiated adenocarcinoma on the base of pyloric gland adenoma.
Acanthosis Nigricans and Insulin Resistance
Authors: Marcio W Lauria, Mario J Saad
Journal: New England Journal of Medicine (2016)

A 27-year-old woman presented with a 2-year history of acanthosis nigricans, hirsutism, and amenorrhea. Laboratory tests revealed elevated levels of insulin and testosterone, the presence of thyroperoxidase antibodies, and an antinuclear antibody titer of 1:64 (normal titer, <1:32).
In vitro characterization of novel nanostructured collagen-hydroxyapatite composite scaffolds doped with magnesium with improved biodegradation rate for hard tissue regeneration
Authors: Iulian V. Antoniac, Aurora Antoniac, Eugeniu Vasile, Camelia Tecu, Marco Fosca, Viktoriya G. Yankova, Julietta V. Rau
Journal: Bioactive Materials (2021)

New materials are required for bone healing in regenerative medicine able to temporarily substitute damaged bone and to be subsequently resorbed and replaced by endogenous tissues. Taking inspiration from basic composition of the mammalian bones, composed of collagen, apatite and a number of substitution ions, among them magnesium (Mg2+), in this work, novel composite scaffolds composed of collagen(10%)-hydroxyapatite (HAp)(90%) and collagen(10%)-HAp(80%)-Mg(10%) were developed. The lyophilization was used for composites preparation. An insight into the nanostructural nature of the developed scaffolds was performed by Scanning Electron Microscopy coupled with Energy Dispersive X-Ray and Transmission Electron Microscopy coupled with Energy Dispersive X-Ray. The HAp nanocrystallite clusters and Mg nanoparticles were homogeneously distributed within the scaffolds and adherent to the collagen fibrils. The samples were tested for degradation in Simulated Body Fluid (SBF) solution by soaking for up to 28 days. The release of Mg from collagen(10%)-HAp(80%)-Mg(10%) composite during the period of up to 21 days was attested, this composite being characterized by a decreased degradation rate with respect to the composite without Mg. The developed composite materials are promising for applications as bone substitute materials favouring bone healing and regeneration.
Ventricular pressure-volume curve indices change with end-diastolic pressure.
Authors: S AGlantz
Journal: Circulation Research (1976)

Many indices have been proposed to describee the diastolic pressure-volume curve mathematically and permit quantification of the elastic properties of the myocardium itself in hopes that changes in the muscle caused by disease would b.e reflected in the diastolic pressure-volume curve. To date, none of the proposed indices has been shown convincingly to discriminate one group of patients from another. While this situation in part arises from the relatively large amount of noise introduced by the technical difficulties of measuring synchronous pressures and volumes during diastole in man, ther is a more fundamental difficulty. In practice, one can measure only a short segment of the entire pressure-volume curve, and the values of all diastolic pressure-volume curve parameters investigated change significantly when one uses different segments of the same pressure-volume curve to compute them. These results were derived from relatively noise-free pressure-volume curves obtained by filling nine excised dog le...
Hypertension
Authors: Meena S. Madhur, Fernando Elijovich, Matthew R. Alexander, Ashley Pitzer, Jeanne Ishimwe, Justin P. Van Beusecum, David M. Patrick, Charles D. Smart, Thomas R. Kleyman, Justin Kingery, Robert N. Peck, Cheryl L. Laffer, Annet Kirabo
Journal: Circulation Research (2021)

Elevated cardiovascular risk including stroke, heart failure, and heart attack is present even after normalization of blood pressure in patients with hypertension. Underlying immune cell activation is a likely culprit. Although immune cells are important for protection against invading pathogens, their chronic overactivation may lead to tissue damage and high blood pressure. Triggers that may initiate immune activation include viral infections, autoimmunity, and lifestyle factors such as excess dietary salt. These conditions activate the immune system either directly or through their impact on the gut microbiome, which ultimately produces chronic inflammation and hypertension. T cells are central to the immune responses contributing to hypertension. They are activated in part by binding specific antigens that are presented in major histocompatibility complex molecules on professional antigen-presenting cells, and they generate repertoires of rearranged T-cell receptors. Activated T cells infiltrate tissues and produce cytokines including interleukin 17A, which promote renal and vascular dysfunction and end-organ damage leading to hypertension. In this comprehensive review, we highlight environmental, genetic, and microbial associated mechanisms contributing to both innate and adaptive immune cell activation leading to hypertension. Targeting the underlying chronic immune cell activation in hypertension has the potential to mitigate the excess cardiovascular risk associated with this common and deadly disease.
<i>PPAR</i>γ Variant Influences Angiographic Outcome and 10-Year Cardiovascular Risk in Male Symptomatic Coronary Artery Disease Patients
Authors: Jakub J. Regieli, J. Wouter Jukema, Pieter A. Doevendans, Aeilko H. Zwinderman, Yolanda van der Graaf, John J. Kastelein, Diederick E. Grobbee
Journal: Diabetes Care (2009)

The effects of peroxisome proliferator–activated receptor (PPAR)γ are largely unknown, and studies of genetic variation are one approach to confirm and estimate its impact on disease in humans. Vasculoprotective effects have been observed preclinically with small-molecule stimulation of the PPARγ pathway. Therefore, it constitutes a potential target of secondary prevention to further reduce cardiovascular risk in patients with manifest vascular disease. Other than our current report, there is no evidence on the impact of genetic variation in PPARγ on cardiovascular prognosis in a secondary prevention setting. Hence, we fully share the opinion of Schneider et al. (1) that the current data are not generalizable and only pertain …
The effects of adriamycin on normal and ouabain-toxic canine Purkinje and ventricular muscle fibers.
Authors: OBinah, I SCohen, M RRosen
Journal: Circulation Research (1983)

In the Na+ lag hypothesis of cardiac glycoside action, [Ca++]i increases through sodium-calcium exchange following block of the sodium-calcium ATPase. This accumulation of [Ca++]i has been suggested to be responsible for digitalis-induced delayed after depolarizations and arrhythmias. We used standard microelectrode techniques to study the effects of adriamycin, 10-200 microM, on the canine Purkinje fiber transmembrane potential. Adriamycin, 10 and 50 microM, had no effect on the action potential other than inducing a 28% increase in duration at 50 microM (p less than 0.01). Adriamycin, 100 and 200 microM, further prolonged action potential duration and decreased amplitude and Vmax. We then studied the effects of adriamycin, 50 microM (a concentration that purportedly blocks sodium-calcium exchange), on ouabain-induced delayed afterdepolarizations and aftercontractions in Purkinje fiber and ventricular muscle. After initially increasing delayed afterdepolarization amplitude in five of nine Purkinje fibe...
Effect of calcification on in vivo mechanical response of rabbit arteries to balloon dilation.
Authors: L LDemer
Journal: Circulation (1991)

BACKGROUNDAtherosclerosis has been associated with loss of artery wall distensibility in human cadavers and in experimental animal models, giving it the lay term hardening of the arteries.METHODS AND RESULTSTo assess the effect of calcification on arterial distensibility, balloon pressure and volume were recorded during dilation of calcified aortas in Watanabe heritable hyperlipidemic (WHHL) rabbits in vivo. Calcification was induced by dietary supplements of cholesterol, vitamin D2, and calcium. Balloon pressure, volume, and time signals were acquired at high frequency with controls for temperature and balloon inflation rate. Resistance to balloon dilation was minimal in control rabbit aortas (delta Vmax = 5.0 +/- 3.5 microliters) and in excised nonatherosclerotic human coronary arteries, and it was small in aortas from cholesterol-fed rabbits (12.3 +/- 8 microliters), even when lipid levels were markedly elevated by a high cholesterol diet (611 +/- 347 mg/dl). With dietary cholesterol, vitamin D2, and...
Bone Disease in Alcohol Abuse
Authors: M. SOSA HENRIQUEZ
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 June 1986Bone Disease in Alcohol AbuseM. SOSA HENRIQUEZ, M.D., P. BETANCOR LEON, M.D., A. FONT THE MORA TURON, M.D., M.C. NAVARRO RODRIGUEZM. SOSA HENRIQUEZ, M.D.Search for more papers by this author, P. BETANCOR LEON, M.D.Search for more papers by this author, A. FONT THE MORA TURON, M.D.Search for more papers by this author, M.C. NAVARRO RODRIGUEZSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-6-893_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Bikle and associates (1) have recently emphasized the relation between bone disease and alcoholism. In their eight patients, they found a marked reduction in active bone resorption and bone formation. Nevertheless, serum levels of calcium, phosphorus, magnesium, calcifediol (25-hydroxyvitamin D3), calcitriol (1α, 25-dihydroxyvitamin D3), parathyroid hormone, and nephrogenous cyclic adenosine monophosphate; and urinary levels of calcium, phosphorus, and magnesium; and maximum tubular resorption of phosphate were normal. The authors therefore suggested that the bone disease in these patients was due to an inhibition of bone remodeling through a mechanism independent of the calciotropic hormones.Osteopenia in alcohol...References1. BIKLEGENANTCANNRECKERHALLORANSTREWLER DHCRBG. Bone disease in alcohol abuse. Ann Intern Med. 1985;103:42-8. LinkGoogle Scholar2. SAVILLE P. Changes in bone mass with age and alcoholism. J Bone Joint Surg. 1965;47A:492-9. CrossrefGoogle Scholar3. LONG R. Hepatic osteodystrophy. Br J Hosp Med. 1978;2:312-21. Google Scholar4. KALBFLEISCHLINDMANGINN JRE. Effect of ethanol administration on urinary excretion of magnesium and calcium in alcoholic and normal subjects. J Clin Invest. 1963;42:1471-5. CrossrefMedlineGoogle Scholar5. KNOCHEL J. Hypophosphatemia in alcoholism. West J Med. 1981;134:15-26. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Colegio Universitario de Las Palmas Las Palmas de Gran Canaria, Canary Islands, Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCirrosis alcohólica y osteodistrofia hepática: ¿cuáles son los principales factores implicados? 1 June 1986Volume 104, Issue 6Page: 893-893KeywordsAlcoholismBoneBone resorptionCalciumHormonesMagnesiumOsteopeniaParathyroid hormonePhosphatesPhosphorus ePublished: 1 December 2008 Issue Published: 1 June 1986 PDF downloadLoading ...