tbuckley/cabot-search huggingface dataset:
Trends and characteristics of hospitalisations from the harmful use of opioids in England between 2008 and 2018: Population-based retrospective cohort study
Authors: Rocco Friebel, Laia Maynou
Journal: Journal of the Royal Society of Medicine (2022)

Summary Objective To examine the trends and characteristics of opioid-related hospital admissions in England over 10 years, and its burden for the National Health Service and public finances. Design Patient-level data from the Hospital Episode Statistics database to examine all opioid-related hospitalisations from 2008 to 2018, stratified by type of opioid admission and patient demographics. Setting All National Health Service hospitals in England. Participants Patients hospitalised from the harmful use of opioids. Main outcome measures The number of opioid-related hospitalisations, length of stay, in-hospital mortality, 30-day readmission rate and treatment costs. Results Opioid-related hospitalisations increased by 48.9%, from 10,805 admissions in 2008 to 16,091 admissions in 2018, with total treatment costs of £137 million. The growth in opioid-related hospitalisations was 21% above the corresponding rate for all other emergency admissions in England. Relative changes showed that hospitalisations increased most for individuals older than 55 years (160%), those living in the most affluent areas of England (93.8%), and suffering from four co-morbidities (627.6%) or more. Hospitals reduced mean patient length of stay from 2.8 days to 1.1 days over 10 years. Mean in-hospital mortality was 0.4% and mean 30-day readmission risk was 16.6%. Conclusion Opioid use is an increasing public health concern in England, though hospitalisation and mortality rates are less pronounced than in other countries. There are concerns about significant rises in hospitalisations from older, less deprived and sicker population groups. Our findings should prompt policymakers to go beyond monitoring mortality statistics when assessing the impacts of harmful use of opioids.
JAMA 75 YEARS AGO
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Resistome and virulome accretion in an NDM-1-producing ST147 sublineage of Klebsiella pneumoniae associated with an outbreak in Tuscany, Italy: a genotypic and phenotypic characterisation
Authors: Vincenzo Di Pilato, Lucia Henrici De Angelis, Noemi Aiezza, Ilaria Baccani, Claudia Niccolai, Eva Maria Parisio, Cesira Giordano, Giulio Camarlinghi, Simona Barnini, Silvia Forni, Lorenzo Righi, Maria Teresa Mechi, Tommaso Giani, Alberto Antonelli, Gian Maria Rossolini
Journal: The Lancet Microbe (2022)
Early colorectal lesion (depressed type) detected using artificial intelligence
Authors: Naoya Toyoshima, Yutaka Saito, Masayoshi Yamada, Hiroyuki Takamaru, Shigeki Sekine, Kengo Kasuga, Shin-ei Kudo
Journal: Endoscopy (2022)

De novo colorectal cancer is a rare nonpolypoid cancer in which the tumor invades the submucosal layer [1]. Unlike with the elevated type, early-stage detection is difficult, and, even if it is detected, the cancer is already advanced due to the rapid speed of invasion.
Surface Expression of Major Allergens on Plant-Made eBioparticle Combines Hypo-Allergenicity with Potent Immune Activation
Authors: Stefanie Busold, Lorenz Aglas, Charlotte Menage, Lydia Auger, Réjean Desgagnés, Loïc Faye, Anne-Catherine Fitchette, Esther de Jong, Caroline Martel, Maria Stigler, Virginie Stordeur, Guy Tropper, Serge Versteeg, Louis Vézina, Véronique Gomord, Teunis Geijtenbeek, Ronald van Ree
Journal: Journal of Allergy and Clinical Immunology (2022)
Correction
Journal: BMJ (1968)

In a circular to hospital authorities (H.M. (68)63) and another to executive councils (E.C.L. 89/68) the Ministry of Health has briefly described the provisions of the Act which concern these authorities.Among those which became effective on 9 September was that in section 5 of the Act giving the Minister of Health power to designate certain hospitals in England and Wales as uni- versity hospitals if he is satisfied that they can provide university facilities for under- graduate or postgraduate clinical teaching.Section 10(3) of the Act empowers a local health authority to arrange with a hospital authority in certain circumstances to make the services of midwives employed by the local health authority available in a hospital.In section 11 provision is made for a local health authority to arrange in certain cir- cumstances for the visiting of patients by health visitors or nurses in places other than their own home.A local health authority may also arrange for the services of its health visitors or nurses to be used by another local health authority.
Metastatic Parotid Gland Carcinoma With ERBB2 Amplification With Complete Response to Fam‐Trastuzumab Deruxtecan
Authors: Navika D. Shukla, Ryan S. Chiang, Alexander D. Colevas
Journal: Journal of the National Comprehensive Cancer Network (2022)

HER2 mutations have been shown to be targetable in select cases of salivary gland cancers with overexpression or amplification of the HER2 oncogene. Fam-trastuzumab deruxtecan, a novel antibody–drug conjugate that combines trastuzumab with a topoisomerase I inhibitor, has recently demonstrated efficacy as a third-line agent in HER2-overexpressing breast cancer after trastuzumab failure. These promising results in breast cancer suggest a potential paradigm for use in other tumors with known HER2 alterations, including salivary gland cancer. This report describes a 67-year-old man with HER2-positive metastatic parotid gland carcinoma who experienced disease progression after parotidectomy with adjuvant cisplatin-based chemoradiation, neratinib, and ado-trastuzumab emtansine. After disease progression on the latter HER2-directed therapy, his malignancy demonstrated complete response to fam-trastuzumab deruxtecan, which has been sustained for the past 7 months. Fam-trastuzumab deruxtecan appears to be a well-tolerated therapeutic option in patients with HER2-positive salivary gland carcinoma, with activity demonstrated after progression on ado-trastuzumab emtansine and HER2-directed kinase inhibition. Further studies should be conducted to explore the use of this agent in HER2-positive salivary gland cancers.
Phase I clinical trial evaluating the safety and efficacy of ADP-A2M10 SPEAR T cells in patients with MAGE-A10<sup>+</sup> advanced non-small cell lung cancer
Authors: George R Blumenschein, Siddhartha Devarakonda, Melissa Johnson, Victor Moreno, Justin Gainor, Martin J Edelman, John V Heymach, Ramaswamy Govindan, Carlos Bachier, Bernard Doger de Spéville, Matthew J Frigault, Anthony J Olszanski, Vincent K Lam, Natalie Hyland, Jean-Marc Navenot, Svetlana Fayngerts, Zohar Wolchinsky, Robyn Broad, Dzmitry Batrakou, Melissa M Pentony, Joseph P Sanderson, Andrew Gerry, Diane Marks, Jane Bai, Tom Holdich, Elliot Norry, Paula M Fracasso
Journal: Journal for ImmunoTherapy of Cancer (2022)

ADP-A2M10 specific peptide enhanced affinity receptor (SPEAR) T cells (ADP-A2M10) are genetically engineered autologous T cells that express a high-affinity melanoma-associated antigen A10 (MAGE-A10)-specific T-cell receptor (TCR) targeting MAGE-A10+ tumors in the context of human leukocyte antigen (HLA)-A*02. ADP-0022-003 was a phase I dose-escalation trial that aimed to evaluate the safety and antitumor activity of ADP-A2M10 in non-small cell lung cancer (NSCLC) (NCT02592577).Eligible patients were HLA-A*02 positive with advanced NSCLC expressing MAGE-A10. Patients underwent apheresis; T cells were isolated, transduced with a lentiviral vector containing the TCR targeting MAGE-A10, and expanded. Patients underwent lymphodepletion with varying doses/schedules of fludarabine and cyclophosphamide prior to receiving ADP-A2M10. ADP-A2M10 were administered at 0.08-0.12×109 (dose group 1), 0.5-1.2×109 (dose group 2), and 1.2-15×109 (dose group 3/expansion) transduced cells.Eleven patients (male, n=6; female, n=5) with NSCLC (adenocarcinoma, n=8; squamous cell carcinoma, n=3) were treated. Five, three, and three patients received cells in dose group 1, dose group 2, and dose group 3/expansion, respectively. The most frequently reported grade ≥3 adverse events were lymphopenia (n=11), leukopenia (n=10), neutropenia (n=8), anemia (n=6), thrombocytopenia (n=5), and hyponatremia (n=5). Three patients presented with cytokine release syndrome (grades 1, 2, and 4, respectively). One patient received the highest dose of lymphodepletion (fludarabine 30 mg/m2 on days -5 to -2 and cyclophosphamide 1800 mg/m2 on days -5 to -4) prior to a second infusion of ADP-A2M10 and had a partial response, subsequently complicated by aplastic anemia and death. Responses included: partial response (after second infusion; one patient), stable disease (four patients), clinical or radiographic progressive disease (five patients), and not evaluable (one patient). ADP-A2M10 were detectable in peripheral blood and in tumor tissue. Peak persistence was higher in patients who received higher doses of ADP-A2M10.ADP-A2M10 demonstrated an acceptable safety profile and no evidence of toxicity related to off-target binding or alloreactivity. There was persistence of ADP-A2M10 in peripheral blood as well as ADP-A2M10 trafficking into the tumor. Given the discovery that MAGE-A10 and MAGE-A4 expression frequently overlap, this clinical program closed as trials with SPEAR T cells targeting MAGE-A4 are ongoing.
Answering the Call
Authors: Phil Gunby
Journal: JAMA (1991)

The medical community—indeed, the entire nation—can be proud of the physicians, nurses, and other members of US military medicine's team who are serving in Operation Desert Storm. From the aid stations close to the front lines to the various ships offshore, US military physicians and their coworkers have been living and working within range of Iraq's arsenal of weapons for up to 6 months. Armed with professional skills, realism engendered by military medical training and caring for the troops in a hostile environment,<sup>1</sup>equipment and supplies transported halfway around the world, and—for some— experience in treating casualties of past armed conflicts, they continue to demonstrate their dedication in the face of many hardships, dangers, uncertainties, and therapeutic challenges. One physician may already be a prisoner of war. Like the thousands of other US military men and women who have been pouring into the Persian Gulf region since Iraq invaded
Iatrogenic Jaundice
Authors: John F. Oliven
Journal: JAMA (1961)

<h3>To the Editor:—</h3> The article "Iatrogenic Jaundice," published inThe Journal, Nov. 26, 1960, page 1690, has scientific merit, but I object to its title, which is needlessly castigating. Dr. Schaffner is discussing drug reactions, not disorders caused by the physician. With the large increase recently in the use of medications which are believed to be potentially hepatotoxic, an article thus entitled helps open the door for a new type of malpractice suit against the innocent physician.
Tenth Annual Symposium for Referring Physicians
Journal: JNCI Journal of the National Cancer Institute (1975)

Tenth Annual Symposium for Referring Physicians JNCI: Journal of the National Cancer Institute, Volume 55, Issue 5, November 1975, Page 1259, https://doi.org/10.1093/jnci/55.5.1259-a Published: 01 November 1975
Exercise capacity, lung and respiratory muscle function in substance use disorders
Authors: R. Mustafaoglu, A. Gorek Dilektaslı, R. Demir, E. Zirek, T. Birinci, E. Kaya Mutlu, C. Evren, A. Razak Ozdincler
Journal: Pulmonology (2022)

Substance use disorder (SUD) causes conditions such as cognitive and behavioral disorders, anxiety, depression, and social isolation it also causes acute airway inflammation by affecting airway bronchial dynamics. The current study aimed to investigate the lung function, respiratory muscle strength, and exercise capacity in patients with SUD. One hundred-eighty three patients with SUD, a total of 119 healthy controls, 54 of whom were cigarette smokers and 65 of whom were non-smokers were included in the study. Spirometric tests, respiratory muscle strength (MIP and MEP), and the 6-Minute Walk Test (6-MWT) were assessed. The III National Health and Nutrition Examination Survey were used to evaluate respiratory symptoms in patients with SUD and cigarette smokers. 86.3% of the SUD patients included in the study were using heroin, 9.2% were cannabis, and 5.5% were spice. The most common symptom in both SUD patients and cigarette smokers was shortness of breath, wheezing, and sputum production. After post-hoc tests, the FVC (p = 0.002), FVC (%predicted) (p < 0.0001), FEV1 (p = 0.002), FEV1 (%predicted) (p < 0.0001), FEV1/FVC (%) (p < 0.0001), PEF (p < 0.0001) and FEF%25-75 (p < 0.0001) lung function parameters were significantly lower in SUD patients than non-smokers. In addition, it was found that MIP (p < 0.0001), MIP (%predicted) (p < 0.0001), MEP (p < 0.0001), and MEP (%predicted) (p < 0.0001) values of SUD patients were significantly lower than non-smokers. The study findings indicate that substance use has an effect on lung functions and the most commonly reported symptoms are shortness of breath, wheezing, and sputum production. In addition, respiratory muscle strength and exercise capacity were decreased in SUD patients compared to non-smokers.
All that glitters is not beta carotene
Authors: S. Hankinson
Journal: JAMA (1994)

After a long series of increasingly optimistic reports about the potential health benefits of dietary antioxidants, two reports of randomized trials considerably dampened the enthusiasm for these nutrients. The Finnish trial of beta carotene and vitamin E failed to show a reduction in lung cancer or cardiovascular disease among heavy smokers,<sup>1</sup>and the Dartmouth trial showed no benefit of antioxidants for prevention of colon polyp recurrence.<sup>2</sup>Now, in this issue ofTHE JOURNAL, two reports appear that link high antioxidant intake with reduced risk of coronary disease and age-related macular degeneration (AMD).<sup>3,4</sup>What are we to make of these findings? See also pp 1413 and 1439. Morris et al<sup>3</sup>observed a strong inverse association between total plasma carotenoids and subsequent risk of coronary heart disease (CHD) (relative risk, 0.64 between highest and lowest quartiles). Individual carotenoids were not assayed; thus, the authors appropriately caution against attributing
Overpopulation underemphasised, says new director
Journal: BMJ (1986)

March issue of the Britsh Jouwnal of Indusrial Medicine.In contrast, increased death rates from mesothelioma, asbestosis, and lung cancer were found among men who had worked with asbestos before the 1%9 letion, says the report, but the group will have to be followed up for a much longer period before any firm conclusions can be drawn. People in the newsThe Princess ofWales is to become the patron of the National Hospitals for Nervous Disease in London, which constitute a special health authority ialising in neurology and neurosurgery.
Correction: Why Are Some Population Interventions for Diet and Obesity More Equitable and Effective Than Others? The Role of Individual Agency
Authors: Jean Adams, Oliver Mytton, Martin White, Pablo Monsivais
Journal: PLoS Medicine (2016)

There is an error in the title of Fig 1.The correct title is: Fig 1. Illustration of the intervention pathway in high-(top) and low-agency (bottom) population interventions.
Massachusetts Medical Society
Authors: Jean Alonzo Curran
Journal: New England Journal of Medicine (1977)

Jean Curran once told a son that he considered himself to be "an average guy who was lucky." The son, however, has summed up and emphasized three qualities that better explain his father's success: "a great capacity for loving and caring, the retention of youthful enthusiasm and humor, and the capacity to work hard and with infinite pains in the many areas of his productive career."Even a cursory inspection of the numerous analytical surveys that he was called upon to undertake at once reveals not only the hard work and infinite pains he took to produce them, but also . . .
Hemolysis in the Spleen Drives Erythrocyte Turnover
Authors: Thomas Klei, Robin Van Bruggen, Jill Dalimot, Martijn Veldthuis, Erik Mul, Timo Rademakers, Mark Hoogenboezem, Sietse Quirijn Nagelkerke, Wilfred Van Ijcken, Soren K. Moestrup, Floris van Alphen, Sander Meijer, Taco Kuijpers, Rob van Zwieten, Pia Svendsen
Journal: Blood (2019)
Long-term adherence and risk of allergic reactions in children who attained milk oral immunotherapy maintenance
Authors: Pasquale Mulé, Bruce Mazer, Danbing Ke, Lydia Zhang, Duncan Lejtenyi, Chiara Lucchesi, Liane Beaudette, Julia Upton, Eyal Grunebaum, Ciriaco Piccirillo, Edmond Chan, Ann Clarke, Xun Zhang, Sofianne Gabrielli, Christine McCusker, Moshe Ben-Shoshan
Journal: Journal of Allergy and Clinical Immunology (2022)
Neighborhood Socioeconomic Environment and Risk of Type 2 Diabetes: Associations and Mediation Through Food Environment Pathways in Three Independent Study Samples
Authors: Lorna E. Thorpe, Samrachana Adhikari, Priscilla Lopez, Rania Kanchi, Leslie A. McClure, Annemarie G. Hirsch, Carrie R. Howell, Aowen Zhu, Farrokh Alemi, Pasquale Rummo, Elizabeth L. Ogburn, Yasemin Algur, Cara M. Nordberg, Melissa N. Poulsen, Leann Long, April P. Carson, Shanika A. DeSilva, Melissa Meeker, Brian S. Schwartz, David C. Lee, Karen R. Siegel, Giuseppina Imperatore, Brian Elbel
Journal: Diabetes Care (2022)

OBJECTIVE We examined whether relative availability of fast-food restaurants and supermarkets mediates the association between worse neighborhood socioeconomic conditions and risk of developing type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS As part of the Diabetes Location, Environmental Attributes, and Disparities Network, three academic institutions used harmonized environmental data sources and analytic methods in three distinct study samples: 1) the Veterans Administration Diabetes Risk (VADR) cohort, a national administrative cohort of 4.1 million diabetes-free veterans developed using electronic health records (EHRs); 2) Reasons for Geographic and Racial Differences in Stroke (REGARDS), a longitudinal, epidemiologic cohort with Stroke Belt region oversampling (N = 11,208); and 3) Geisinger/Johns Hopkins University (G/JHU), an EHR-based, nested case-control study of 15,888 patients with new-onset T2D and of matched control participants in Pennsylvania. A census tract–level measure of neighborhood socioeconomic environment (NSEE) was developed as a community type-specific z-score sum. Baseline food-environment mediators included percentages of 1) fast-food restaurants and 2) food retail establishments that are supermarkets. Natural direct and indirect mediating effects were modeled; results were stratified across four community types: higher-density urban, lower-density urban, suburban/small town, and rural. RESULTS Across studies, worse NSEE was associated with higher T2D risk. In VADR, relative availability of fast-food restaurants and supermarkets was positively and negatively associated with T2D, respectively, whereas associations in REGARDS and G/JHU geographies were mixed. Mediation results suggested that little to none of the NSEE–diabetes associations were mediated through food-environment pathways. CONCLUSIONS Worse neighborhood socioeconomic conditions were associated with higher T2D risk, yet associations are likely not mediated through food-environment pathways.
Correction
Journal: BMJ (1928)

9~~~~~~~~EGADADWLSEIA OEiZ related to the controlling factors of cellular differentiation which appear to be inherently connected with the relationship between onie type of somatic cell and another adjacent type.So it niay be that metabolic isolation of a cell can be construed illto a condition whereby there is a withdrawal or loss of the control of differentiation, or, indeed, it may be that the altered chemical state of the damaged cell may break some chlemical relatioiiship with, aind control by, adjacenit cells.
Pooled Safety Data from Phase 3 Studies of Epicutaneous Immunotherapy for Peanut Allergy in Children Aged 4-11 Years
Authors: Jacqueline Pongracic, Andrew Bird, Amy Scurlock, Dianne Campbell, Jonas Meney, Aurélie Peillon, Hugh Sampson, David Fleischer, Rachel Robison, Katharine Bee
Journal: Journal of Allergy and Clinical Immunology (2022)
APPLICATION OF MALLORY'S CONNECTIVE TISSUE STAIN TO FORMALDEHYD-PRESERVED TISSUES
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal