tbuckley/cabot-search huggingface dataset:
SIRT1 in the cardiomyocyte counteracts doxorubicin-induced cardiotoxicity via regulating histone H2AX
Authors: Atsushi Kuno, Ryusuke Hosoda, Miki Tsukamoto, Tatsuya Sato, Hiromi Sakuragi, Nami Ajima, Yukika Saga, Kouhei Tada, Yoshiki Taniguchi, Naotoshi Iwahara, Yoshiyuki Horio
Journal: Cardiovascular Research (2022)

Cardiotoxicity by doxorubicin predicts worse prognosis of patients. Accumulation of damaged DNA has been implicated in doxorubicin-induced cardiotoxicity. SIRT1, an NAD+-dependent histone/protein deacetylase, protects cells by deacetylating target proteins. We investigated whether SIRT1 counteracts doxorubicin-induced cardiotoxicity by mediating Ser139 phosphorylation of histone H2AX, a critical signal of the DNA damage response.Doxorubicin (5 mg/kg per week, x4) was administered to mice with intact SIRT1 (Sirt1f/f) and mice that lack SIRT1 activity in cardiomyocytes (Sirt1f/f;MHCcre/+). Reductions in left ventricular fractional shortening and ejection fraction by doxorubicin treatment were more severe in Sirt1f/f;MHCcre/+ than in Sirt1f/f. Myocardial expression level of type-B natriuretic peptide was 2.5-fold higher in Sirt1f/f;MHCcre/+ than in Sirt1f/f after doxorubicin treatment. Sirt1f/f;MHCcre/+ showed larger fibrotic areas and higher nitrotyrosine levels in the heart after doxorubicin treatment. Although doxorubicin-induced DNA damage evaluated by TUNEL staining was enhanced in Sirt1f/f;MHCcre/+, the myocardium from Sirt1f/f;MHCcre/+ showed blunted Ser139 phosphorylation of H2AX by doxorubicin treatment. In H9c2 cardiomyocytes, SIRT1 knockdown attenuated Ser139 phosphorylation of H2AX, increased DNA damage, and enhanced caspase-3 activation under doxorubicin treatment. Immunostaining revealed that acetylation level of H2AX at Lys5 was higher in hearts from Sirt1f/f;MHCcre/+. In H9c2 cells, acetyl-Lys5-H2AX level was increased by SIRT1 knockdown and reduced by SIRT1 overexpression. Ser139 phosphorylation in response to doxorubicin treatment was blunted in a mutant H2AX with substitution of Lys5 to Gln (K5Q) that mimics acetylated lysine compared with that in wild-type H2AX. Expression of K5Q-H2AX as well as S139A-H2AX, which cannot be phosphorylated at Ser139, augmented doxorubicin-induced caspase-3 activation. Treatment of mice with resveratrol, a SIRT1 activator, attenuated doxorubicin-induced cardiac dysfunction, which was associated with a reduction in acetyl-Lys5-H2AX level and a preserved phospho-Ser139-H2AX level.These findings suggest that SIRT1 counteracts doxorubicin-induced cardiotoxicity by mediating H2AX phosphorylation through its deacetylation in cardiomyocytes.
Single‐cell profiling of human CD127+ innate lymphoid cells reveals diverse immune phenotypes in hepatocellular carcinoma
Authors: Yuanlin He, Jiajing Luo, Guannan Zhang, Yu Jin, Nanxi Wang, Jinying Lu, Changxian Li, Xiaohuan Guo, Na Qin, Juncheng Dai, Yun Chen
Journal: Hepatology (2022)

Innate lymphoid cells (ILCs) are tissue-resident lymphocytes that play critical roles in cytokine-mediated regulation of homeostasis and inflammation. However, relationships between their immune phenotypic characteristics and HCC remain largely unexplored.We performed single-cell RNA sequencing analysis on sorted hepatic ILC cells from human patients with HCC and validated using flow cytometry, multiplex immunofluorescence staining, and functional experiments. Moreover, we applied selection strategies to enrich ILC populations in HCC samples to investigate the effects of B cells on the immune reaction of inducible T cell costimulator (ICOS)+ ILC2 cells. Dysregulation of ILCs was manifested by the changes in cell numbers or subset proportions in HCC. Seven subsets of 3433 ILCs were identified with unique properties, of which ICOS+ ILC2a were preferentially enriched in HCC and correlated with poor prognosis. Mechanistically, we report that B cells, particularly resting naïve B cells, have a previously unrecognized function that is involved in inflammatory differentiation of ILC2 cells. B cell-derived ICOSL signaling was responsible for exacerbating inflammation through the increased production of IL-13 in ICOS+ ILC2a cells. Heat shock protein 70 (HSP70) genes Heat Shock Protein Family A Member 1A (HSPA1A) and Heat Shock Protein Family A Member 1B (HSPA1B) were highly expressed in ILC2s in late-stage HCC, and targeting to ICOS and its downstream effector HSP70 in ILC2s suppressed tumor growth and remodeled the immunosuppressive tumor microenvironment.This in-depth understanding sheds light on B cell-driven innate type 2 inflammation and provides a potential strategy for HCC immunotherapy.
Finerenone in patients with chronic kidney disease and type 2 diabetes with and without heart failure: a prespecified subgroup analysis of the <scp>FIDELIO‐DKD</scp> trial
Authors: Gerasimos Filippatos, Bertram Pitt, Rajiv Agarwal, Dimitrios Farmakis, Luis M. Ruilope, Peter Rossing, Johann Bauersachs, Robert J. Mentz, Peter Kolkhof, Charlie Scott, Amer Joseph, George L. Bakris, Stefan D. Anker
Journal: European Journal of Heart Failure (2022)
et al, THE NEW FRATERNITY
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Disseminated Herpes Infection Following Talimogene Laherparepvec Administration
Authors: Brooks David Kimmis, Yen Luu, Hongyan Dai
Journal: JAMA Dermatology (2022)

This case report describes a 69-year-old woman who received treatment with ipilimumab and talimogene laherparepvec therapy following metastasis of melanoma to the left inguinal lymph nodes, skin of left lower extremity, and vulva.
Bringing to Light the Risk of Burns From Retained Metal Jewelry Piercings During Electrosurgery—Torching the Myth
Authors: Nicole Blumenstein, Johanna Wickemeyer, Ari Rubenfeld
Journal: JAMA Surgery (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Systematic comparison between BNT162b2 and CoronaVac in the seroprotection against SARS-CoV-2 Alpha, Beta, Gamma, and Delta variants
Authors: Wing Ying Au, Chengjin Ye, Sydney Leigh Briner, Gianmarco Domenico Suarez, Jeewon Han, Xinzhou Xu, Jun-Gyu Park, Melinda Ann Brindley, Luis Martinez-Sobrido, Peter Pak-Hang Cheung
Journal: Journal of Infection (2022)
CDK4/6 Inhibitors Induce Antitumor Immunity
Journal: Cancer Discovery (2017)

Abstract CDK4/6 inhibitors not only induce cell-cycle arrest but also promote antitumor immunity by stimulating the production of type III interferons, which enhance tumor antigen presentation, and suppress regulatory T cells. The immune effects of these drugs provide a rationale for combining CDK4/6 inhibitors with checkpoint blockade agents.
The first year of life. Jaundice in the newborn.
Authors: H B Valman
Journal: BMJ (1980)

Jaundice is a yellow colour of the skin caused by high concentrations of bilirubin.Very severe jaundice may damage the cells of the basal ganglia and brain stem.This damage is produced by the fat-soluble unconjugated 'c biA' blirubin& bilirubin.If jaundice is severe high bilirubin levels may result in deafness, * Liver ted w~ir ' cerebral palsy, or death.Common causes of jaundice in the newborn ..... ..
Author correction to “Development of small-molecule tropomyosin receptor kinase (TRK) inhibitors for NTRK fusion cancers” [Acta Pharmaceutica Sinica B 11 (2021) 355–372]
Authors: Tingting Jiang, Guan Wang, Yao Liu, Lu Feng, Meng Wang, Jie Liu, Yi Chen, Liang Ouyang
Journal: Acta Pharmaceutica Sinica B (2022)

[This corrects the article DOI: 10.1016/j.apsb.2020.05.004.].
Prevalence of antibody to HTLV-III in haemophiliacs in the United Kingdom.
Authors: S Zaman, M Tredger, J Johnson, Roger Williams
Journal: BMJ (1986)

Prevalence of antibody to HTLV-III inl haemophiliacs in the United Kingdom Haemophiliacs receiving treatment with blood coagulation factor are at risk of infection with human T cell lymphotropic virus type III (HTLV-III) (or lymphadenopathy associated virus),' the agent thought to cause the acquired immune deficiency syndrome (AIDS).2 3 Studies carried out in different parts ofthe United Kingdom have shown that many haemophiliacs now have on 12 August 2023 by guest.
Routine lung volume recruitment in boys with Duchenne muscular dystrophy: a randomised clinical trial
Authors: Sherri L Katz, Jean K Mah, Hugh J McMillan, Craig Campbell, Vid Bijelić, Nick Barrowman, Franco Momoli, Henrietta Blinder, Shawn D Aaron, Laura C McAdam, The Thanh Diem Nguyen, Mark Tarnopolsky, David F Wensley, David Zielinski, Louise Rose, Nicole Sheers, David J Berlowitz, Lisa Wolfe, Doug McKim
Journal: Thorax (2022)

Impaired cough results in airway secretion retention, atelectasis and pneumonia in individuals with Duchenne muscular dystrophy (DMD). Lung volume recruitment (LVR) stacks breaths to inflate the lungs to greater volumes than spontaneous effort. LVR is recommended in DMD clinical care guidelines but is not well studied. We aimed to determine whether twice-daily LVR, compared with standard of care alone, attenuates the decline in FVC at 2 years in boys with DMD.
CDC Statement on Study Results of Product Containing Nonoxynol-9
Journal: JAMA (2000)

SICKLE CELL DISEASE (SCD) IS A COMmon single-gene disorder that affects three of every 1000 black newborns and approximately 50,000 persons in the United States. 1 Children affected with SCD are at increased risk for severe morbidity (e.g., severe hemolytic anemia, splenic dysfunction, pain crises, and bacterial infections) and mortality, especially during the first 3 years of life. 1,2In 1993, California, Illinois, and New York collectively accounted for approximately 20% of all births to blacks.All three states offer universal newborn screening for hemoglobinopathies.To assess the effectiveness of newborn screening programs for SCD and for receipt of and compliance with early medical interventions (e.g., penicillin prophylaxis and pneumococcal vaccination and other vaccination patterns), a 3-year collaborative follow-up study was conducted from 1995 through 1998 in California, Illinois, and New York. 3This report summarizes the results of this study, which demonstrate the difficulty in retrospectively finding children who were screened at birth so that data for evaluating program effectiveness can be assessed.The study comprised children born in 1992 and 1993 and in whom SCD was diagnosed during 1992-1993.Follow-up information about these children was ascertained through complementary surveys administered to parents and physicians of affected children.State health departments administered physician surveys, which were mailed to the child's last known provider.Parental sur-veys were administered by Battelle/ Survey Research Associates, Inc., which conducted telephone interviews and, along with the respective health departments, made repeated attempts to locate the children.During 1992-1993, SCD was diagnosed in 1042 children in California (265 cases), Illinois (254), and New York (523).Fourteen children (six in California, three in Illinois, and five in New York) died before the study began.Completed physician surveys were returned for 752 (72%) of the children (144 in California, 254 in Illinois, and 354 in New York).Parental surveys were completed for 252 (24%) children (87 in California, 52 in Illinois, and 113 in New York).When data from both surveys were merged, physician and parental surveys were completed for 184 (18%) children.Among physician respondents, 575 (76%) reported providing antibiotic (penicillin) prophylaxis to their SCD patients; 253 (44%) patients complied with the prophylaxis antibiotic regimen.One hundred eighty-nine (25%) patients received pneumococcal vaccine, and 179 (24%) received at least the first dose of Haemophilus influenzae type b vaccine (Hib).
Expanding oesophageal cancer research and care in eastern Africa
Authors: Christian C. Abnet, Geoffrey C. Buckle, Yingxi Chen, Sanford M. Dawsey, Violet Kayamba, Michael M. Mwachiro, Charles Dzamalala, David E. Fleischer, Bongani Kaimila, Paul Kelly, Christopher Mathew, Valerie McCormack, Stephen J. Meltzer, Diana Menya, Daniel Middleton, Blandina T. Mmbaga, Elia Mmbaga, Gift Mulima, Beatrice Mushi, M. Iqbal Parker, Msiba Selekwa, Mark D. Topazian, Yona Ringo, Joachim Schüz, Katherine Van Loon, Russell E. White
Journal: Nature reviews. Cancer (2022)
Royal Berkshire Hospital: Practice of Mr. F. A. Bulley
Journal: BMJ (1842)

preseniting naliurally; it was most frequenitly found that one child presented naturally by the vertex, whilst the other presented by the breech or the foot.The longest period which he recollected to have in- tervened between the birth of each child was fourteen hoturs.In that case the presentation of the seconId child was a natural one, but there was a total absenlce of uterine pain.Mr. SNOW stated that his experience, respectinig the varied presentations in twiin cases, coiiicided with that of Mr. Dunn.He remembered atteniding, one case of twins in which one child presented by the slhoulder, anid thc other by the knee.Mr. STREETER said that, in the practice of Dr.Collins and Dr. Ramsbotlham, the majority of tllc childrein presented naturally; there were, howevem, occasional and frequent variations to this rule.Januztary 29.LITIOTRirsy.
Regulating CAR T Cells: A Remote Control Approach
Journal: Cancer Discovery (2016)

Researchers have synthesized small organic molecules called adaptors that have a tumor-specific ligand on one end and FITC on the other. Instead of engineering a different chimeric antigen receptor (CAR) on T cells for each unique tumor antigen, these antigen-specific adaptors can be used to bridge FITC-binding CAR T and tumor cells.
JOHN HOWARD (1726[27]-1790)— PRISON REFORMER AND PHILANTHROPIST
Journal: JAMA (1965)

Johnrd, prison reformer of England, gave a fortune to accumulate data in support of his private mission to eradicate the wretched conditions in prisons, hospitals, and lazarettos and to prevent the plague in such institutions. He was born near London at Enfield or Hackney; there is uncertainty regarding his birth year as well as birthplace.<sup>1</sup>His father, a Protestant dissenter who engaged in the upholstery and carpet business, died when his son was just beginning an upper class education. He had only partially fulfilled the wish of his father— that he serve an apprenticeship to a wholesale grocer—when he obtained a release from his indenture and toured the Continent. In 1756, on a visit to Portugal as a passenger on the Lisbon packet, Howard was captured by a French privateer, was imprisoned in France, and suffered great privations. He was first held captive without food or water for almost
Natural killer T cell immunotherapy combined with IL-15-expressing oncolytic virotherapy and PD-1 blockade mediates pancreatic tumor regression
Authors: Adam Nelson, Simon Gebremeskel, Brian D Lichty, Brent Johnston
Journal: Journal for ImmunoTherapy of Cancer (2022)

Background Pancreatic cancer is one of the leading causes of cancer death, with a 5-year -year survival rate of less than 10%. This results from late detection, high rates of metastasis, and resistance to standard chemotherapies. Furthermore, chemotherapy and radiation are associated with significant morbidity, underscoring the need for novel therapies. Recent clinical studies have shown that immunotherapies can provide durable outcomes in cancer patients, but successes in pancreatic cancer have been limited. It is likely that novel and combined therapies will be needed to achieve clinical benefits. Methods Using experimental mouse models of pancreatic ductal adenocarcinoma, we examined natural killer T (NKT) cell activation therapy in combination with a recombinant oncolytic vesicular stomatitis virus (VSVΔM51) engineered to express the cytokine IL-15 (VSV-IL-15). Panc02 pancreatic ductal carcinoma cells were implanted subcutaneously or orthotopically into syngeneic C57BL/6 mice. Mice were then treated with VSV expressing green fluorescent protein (VSV-GFP) or VSV-IL-15 and/or NKT cell activation therapy via delivery of α-GalCer-loaded DCs. We further assessed whether the addition of PD-1 blockade could increase the therapeutic benefit of our combination treatment. Three days after NKT cell activation, some groups of mice were treated with anti-PD-1 antibodies weekly for 3 weeks. Results VSV-GFP and VSV-IL-15 mediated equal killing of human and mouse pancreatic cancer lines in vitro. In vivo, VSV-IL-15 combined with NKT cell activation therapy to enhance tumor regression and increase survival time over individual treatments, and was also superior to NKT cell therapy combined with VSV-GFP. Enhanced tumor control was associated with increased immune cell infiltration and anti-tumor effector functions (cytotoxicity and cytokine production). While ineffective as a monotherapy, the addition of blocking PD-1 antibodies to the combined protocol sustained immune cell activation and effector functions, resulting in prolonged tumor regression and complete tumor clearance in 20% of mice. Mice who cleared the initial tumor challenge exhibited reduced tumor growth uponon rechallenge, consistent with the formation of immune memory. Conclusion TThese results demonstrate that NKT cell immunotherapy combined with oncolytic VSV-IL-15 virotherapy and PD-1 blockade enhances tumor control and presents a promising treatment strategy for targeting pancreatic cancer.
Long term monthly follow-up of patients with chronic anti-HBe positive hepatitis B treated with different interferon types and schedules . Dept.of Gastroenterology Molinete Hosp., Torino; *Inf. Dis. Clinic, University of Bari; &amp;Niguarda Hosp., Milano; $Bolognini Hosp. Bergamo; Prodotti Roche, Milano, Italy
Journal: Hepatology (1995)
Re: Luke Harper, T. Blanc, M. Peycelon, et al. Circumcision and Risk of Febrile Urinary Tract Infection in Boys with Posterior Urethral Valves: Result of the CIRCUP Randomized Trial. Eur Urol. 2022;81:64–72
Authors: Abhay Singh Gaur, Prasant Nayak
Journal: European Urology (2021)
COVID-19 vaccine testing in pregnant females is necessary
Authors: Sabra L. Klein, Patrick S. Creisher, Irina Burd
Journal: Journal of Clinical Investigation (2021)

Pregnancy and COVID-19According to the US Centers for Disease Control and Prevention (CDC), onequarter of reproductive-aged women (i.e., 15-49 years of age) hospitalized with coronavirus disease 2019 (COVID-19) from March 1-August 22, 2020, were pregnant, and pregnant women were more likely to require mechanical ventilation than nonpregnant women (1).The CDC also reports that cisgender women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during pregnancy are at higher risk for preterm birth (2).Gestation-associated physical, immunological, and endocrinological changes typically place pregnant women and their fetuses at greater risk for severe complications caused by infectious diseases, which is not unique to SARS-CoV-2 (3).Currently, all studies and references are for cisgender women, because there is a paucity of information on SARS-CoV-2 infection and vaccination during transgender pregnancies.
Cell membrane coated-nanoparticles for cancer immunotherapy
Authors: Yingping Zeng, Sufen Li, Shufen Zhang, Li Wang, Hong Yuan, Fuqiang Hu
Journal: Acta Pharmaceutica Sinica B (2022)

Cancer immunotherapy can effectively inhibit cancer progression by activating the autoimmune system, with low toxicity and high effectiveness. Some of cancer immunotherapy had positive effects on clinical cancer treatment. However, cancer immunotherapy is still restricted by cancer heterogeneity, immune cell disability, tumor immunosuppressive microenvironment and systemic immune toxicity. Cell membrane-coated nanoparticles (CMCNs) inherit abundant source cell-relevant functions, including "self" markers, cross-talking with the immune system, biological targeting, and homing to specific regions. These enable them to possess preferred characteristics, including better biological compatibility, weak immunogenicity, immune escaping, a prolonged circulation, and tumor targeting. Therefore, they are applied to precisely deliver drugs and promote the effect of cancer immunotherapy. In the review, we summarize the latest researches of biomimetic CMCNs for cancer immunotherapy, outline the existing specific cancer immune therapies, explore the unique functions and molecular mechanisms of various cell membrane-coated nanoparticles, and analyze the challenges which CMCNs face in clinical translation.
The role of small airway dysfunction in asthma control and exacerbations: a longitudinal, observational analysis using data from the ATLANTIS study
Authors: Monica Kraft, Matthew Richardson, Brian Hallmark, Dean Billheimer, Maarten Van den Berge, Leonardo M Fabbri, Thys Van der Molen, Gabriele Nicolini, Alberto Papi, Klaus F Rabe, Dave Singh, Chris Brightling, Salman Siddiqui
Journal: The Lancet Respiratory Medicine (2022)
Hydroa
Authors: H. R. Crocker
Journal: BMJ (1886)

fW^0!2, I an out of eight, nearly opposite the Qurter Guard, and war not to ticed and removed until he had been there for one or two hours I r.ret the mneagr, nature of this report as regards details of clinical or pathological interest, but hope that the circumstances will be considered sufficient excuse.All that was posible, under such .