tbuckley/cabot-search huggingface dataset:
Questions concerning tyrosine kinase-inhibitor therapy and transplants in chronic phase chronic myeloid leukaemia
Authors: Michele Baccarani, Francesca Bonifazi, Simona Soverini, Fausto Castagnetti, Gabriele Gugliotta, Wael Saber, Noel Estrada-Merly, Gianantonio Rosti, Robert Peter Gale
Journal: Leukemia (2022)

Abstract In this provocative commentary, we consider several questions posed by the late chronic myeloid leukaemia (CML) expert Prof. Michele Baccarani, which he challenged us to address after his death. He noted only a small proportion of people with chronic phase CML receiving tyrosine kinase-inhibitor (TKI)-therapy are likely to achieve sustained therapy-free remission (TFR) and even fewer are likely to be cured. Persons most likely to fail TKItherapy can be identified at diagnosis or soon after starting TKI-therapy. These persons are likely to need lifetime TKI-therapy with attendant risks of adverse events, cost and psychological consequences. Allogeneic transplants achieve much higher rates of leukaemia-free survival compared with TKI-therapy but are associated with transplant-related adverse events including an almost 20 percent risk of transplant-related deaths within 1 year post-transplant and a compromised quality-of-life because of complications such as chronic graft-versus-host disease. Subject-, disease- and transplant-related co-variates associated with transplant outcomes are known with reasonable accuracy. Not everyone likely to fail TKI-therapy is a transplant candidate. However, in those who candidates are physicians and patients need to weigh benefits and risks of TKI-therapy versus a transplant. We suggest transplants should be more often considered in the metric when counseling people with chronic phase CML unlikely to achieve TFR with TKI-therapy. We question whether we are discounting a possible important therapy intervention; we think so.
Community-based rehabilitation intervention for people with schizophrenia in Ethiopia (RISE): results of a 12-month cluster-randomised controlled trial
Authors: Laura Asher, Rahel Birhane, Helen A Weiss, Girmay Medhin, Medhin Selamu, Vikram Patel, Mary De Silva, Charlotte Hanlon, Abebaw Fekadu
Journal: The Lancet Global Health (2022)

Community-based rehabilitation (CBR) is recommended to address the social and clinical needs of people with schizophrenia in resource-poor settings. We evaluated the effectiveness of CBR at reducing disability at 12 months in people with schizophrenia who had disabling illness after having had the opportunity to access facility-based care for 6 months METHODS: This cluster-randomised controlled trial was conducted in a rural district of Ethiopia. Eligible clusters were subdistricts in Sodo district that had not participated in the pilot study. Available subdistricts were randomised (in a 1:1 ratio) to either the intervention group (CBR plus facility-based care) or to the control group (facility-based care alone). An optimisation procedure (accounting for the subdistrict mean WHO Disability Assessment Schedule (WHODAS) score and the potential number of participants per subdistrict) was applied for each of the eight health facilities in the district. An independent statistician, masked to the intervention or control label, used a computer programme to randomly choose the allocation sequence from the set of optimal ones. We recruited adults with disabling illness as a result of schizophrenia. The subdistricts were eligible for inclusion if they included participants that met the eligibility criteria. Researchers recruiting and assessing participants were masked to allocation status. Facility-based care was a task-shared model of mental health care integrated within primary care. CBR was delivered by lay workers over a 12-month period, comprising of home visits (psychoeducation, adherence support, family intervention, and crisis management) and community mobilisation. The primary outcome was disability, measured with the proxy-rated 36-item WHODAS score at 12 months. The subdistricts that had primary outcome data available were included in the primary analysis. This study is registered with ClinicalTrials.gov, NCT02160249.
EUS-GUIDED GASTROENTEROSTOMY TECHNIQUES FOR PALLIATION OF MALIGNANT GASTRIC OUTLET OBSTRUCTION: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: P.H. Boraschi Vieira Ribas, I. Mendonça Proença, E. Silvino Do Monte Junior, V. Lira De Oliveira, M. Candido Hemerly, E.Y. Yvamoto, S.A. SÁNCHEZ-LUNA, W. Marques Bernardo, D. Turiani Hourneaux de Moura, E. Guimaraes Hourneaux De Moura
Journal: Endoscopy (2022)

Aims Malignant gastric outlet obstruction(GOO) is usually associated with poor prognosis and an important decrease in the quality of life. Ultrasound-guided endoscopic gastroenterostomy(EUS-GE) has emerged as a safe and effective palliation procedure for GOO. We aimed to compare the currently available techniques in this systematic review with meta-analysis.
Anterior pouch flexible endoscopic septal division: an alternative therapy for patients with a neopharyngeal pseudodiverticulum
Authors: Victoria S. L. Kok, Spiro Raftopoulos
Journal: Endoscopy (2022)

Oropharyngeal dysphagia secondary to a neopharyngeal pseudodiverticulum can occur in up to 60 % of patients who undergo total laryngectomy [1]. At least nine studies have reported on these symptomatic patients [2]. We describe the first case of anterior pouch flexible endoscopic septal division (FESD) in a patient with a neopharyngeal pseudodiverticulum.
CCL22 mutations drive natural killer cell lymphoproliferative disease by deregulating microenvironmental crosstalk
Authors: Constance Baer, Shunsuke Kimura, Mitra S. Rana, Andrew B. Kleist, Tim Flerlage, David J. Feith, Peter Chockley, Wencke Walter, Manja Meggendorfer, Thomas L. Olson, HeeJin Cheon, Kristine C. Olson, Aakrosh Ratan, Martha-Lena Mueller, James M. Foran, Laura J. Janke, Chunxu Qu, Shaina N. Porter, Shondra M. Pruett-Miller, Ravi C. Kalathur, Claudia Haferlach, Wolfgang Kern, Elisabeth Paietta, Paul G. Thomas, M. Madan Babu, Thomas P. Loughran, Ilaria Iacobucci, Torsten Haferlach, Charles G. Mullighan
Journal: Nature Genetics (2022)
NEW STEP APPROACH FOR TREATMENT OF LARGE SIZE INFECTED PANCREATIC NECROSIS: PERCUTANEOUS ENDOSCOPIC NECROSECTOMY FOLLOWED BY TRANSLUMINAL DRAINAGE/NECROSECTOMY
Authors: S. Mangiafico, H. Bertani, F. Pigò, M. Lupo, G. Grande, S. Russo, S. Cocca, R. Conigliaro
Journal: Endoscopy (2022)

Aims We report a case series of a new endoscopic approach to treat infected pancreatic necrosis (IPN).
ENDOSCOPIC TREATMENT OF LIVER HYDATID CYSTS WITH INTRA BILIARY RUPTURE
Authors: S. Rami, O. Elmqaddem, F. Adamou, F. Amri, M. Nasiri, A. Zazour, W. Khannoussi, G. Kharrasse, Z. Ismaili
Journal: Endoscopy (2022)

Aims Study the contribution of ERCP in the management of liver hydatid cysts with intrabiliary rupture.
ROS Turn Nanoparticle Fluorescence on for Imaging <i>Staphylococcus aureus</i> Infection In Vivo
Authors: Lingling Xu, Wenjun Zhan, Yu Deng, Xiaoyang Liu, Ge Gao, Xianbao Sun, Gaolin Liang
Journal: Advanced Healthcare Materials (2022)

Abstract Direct, noninvasive, and real‐time imaging of Staphylococcus aureus ( S. aureus ) infection is of great value for quick diagnosis of related disease in clinic, but remains challenging. Herein, employing a rationally designed near‐infrared fluorescence probe Cys(StB u)‐EDA‐Thioketal‐Lys(Cy5.5)‐CBT (TK‐CBT) and a CBT‐Cys click reaction, the fluorescence‐quenched nanoparticles TK‐CBT‐NPs are facilely prepared. Upon oxidation by the abundant reactive oxygen species in S. aureus ‐infected macrophages, TK‐CBT‐NPs are fractured, turning the fluorescence “on” for imaging infections in vitro and in vivo. Specifically, TK‐CBT‐NPs show a 6.1‐fold fluorescence imaging signal enhancement of the macrophages that are infected by S. aureus for 20 h in vitro. At 4 h postinjection, TK‐CBT‐NPs show a 2.8‐fold fluorescence imaging signal enhancement of the sites in mice that are infected by S. aureus for 24 h. It is anticipated that TK‐CBT‐NPs could be applied for diagnosis of S. aureus infections in clinic in the near future.
Multiple and Diffuse Gliomas by 18F-Fluorocholine PET/CT
Authors: Ana María García Vicente, Julian Pérez-Beteta, Jesús J. Bosque, Ángel María Soriano Castrejón, Víctor Manuel Pérez-García
Journal: Clinical Nuclear Medicine (2022)

Gliomas are characterized by an inherent diffuse and irregular morphology that prevents defining a boundary between tumor and healthy tissue, both in imaging assessment and surgical field. The effective identification of the extent of the disease in diffuse and multiple gliomas is crucial for their management but doing so by radiological means can be challenging. We present a broad spectrum of diffuse and multiple gliomas using 18F-fluorocholine PET/CT, demonstrating the potential of metabolic imaging in the evaluation of these gliomas, with implications in patient clinical management and outcome.
STAGING OF BARRETT’S NEOPLASIA USING ARTIFICIAL NEURAL NETWORKS, PROOF OF CONCEPT STUDY
Authors: M. Abdelrahim, M. Saiko, N. Maeda, H. Htet, K. Siggens, S. Aslam, S. Subramaniam, G. Longcroft-Wheaton
Journal: Endoscopy (2022)

Aims Endoscopic differentiation between intra-mucosal and submucosal Barrett’s neoplasia has several important implications but remains challenging even for expert endoscopists. Recent studies demonstrated promising results on AI-assisted detection of Barrett’s neoplasia, but data on AI-assisted staging is limited. We aimed to develop and validate an AI system for classification of Barrett’s neoplasia into intra-mucosal or submucosal, and compare its performance to expert endoscopists.
ESOPHAGEAL STENTS IN THE PALLIATIVE TREATMENT OF MALIGNANT STENOSIS
Authors: M. Oustani, A. Zazour, W. Khannoussi, G. Kharrasse, Z. Ismaili
Journal: Endoscopy (2022)

Aims To evaluate the efficiency of the placement of an esophageal stent in the palliative treatment of malignant stenosis.
IMPACT OF THE COVID-19 PANDEMIC ON THE DIAGNOSIS OF COLORECTAL CANCERS
Authors: S. Mrabti, A. Benhamdane, T. Addajou, A. Sair, M.O. Guelleh, A. Touibi, S. Rokhsi, I. Radouane, H. Iloghmane, R. Laaroussi, R. Berrida, S. Sentissi, I. El Koti, F. Rouibaa, A. Benkirane, H. Seddik
Journal: Endoscopy (2022)

Aims The objective of this study was to assess the impact of the COVID-19 pandemic on the diagnosis of colorectal cancers.
ADENOMA MISS RATE IN BACK-TO-BACK ENDOCUFF-ASSISTED COLONOSCOPY. A SINGLE-CENTER PROSPECTIVE STUDY. PRELIMINARY RESULTS
Authors: M. Fragaki, P. Nikolaou, D. Arna, A. Psistakis, M. Velegraki, E. Voudoukis, A. Theodoropoulou, E. Vardas, G. Paspatis
Journal: Endoscopy (2022)

Aims To conduct a back-to-back endoscopy study and to evaluate the contribution of endocuff assisted colonoscopy to the detection of missed adenomas in a mixed population of colorectal cancer (CRC) screening/surveillance and symptomatic patients. To the best of our knowledge, this is the first study on this issue.
A NOVEL COMPUTER-AIDED DETECTION (CADE) MODEL FOR NEOPLASIA DETECTION IN INFLAMMATORY BOWEL DISEASE. THE BEGINNING OF THE END OF CHROMOENDOSCOPY?
Authors: M. Abdelrahim, Y. Iwadate, N. Maeda, H. Htet, K. Siggens, S. Aslam, P. Bhandari
Journal: Endoscopy (2022)

Aims IBD neoplasia is often subtle and easily missed, hence chromoendoscopy is recommended. CADe showed promising results in neoplasia detection in non-IBD patients. However, data on its use for neoplasia detection in IBD is lacking. We aimed to develop and validate a dedicated CADe system for neoplasia detection in IBD and compare it with an existing generic CADe system used on IBD colons.
Blockade or Deletion of IFNγ Reduces Macrophage Activation without Compromising CAR T-cell Function in Hematologic Malignancies
Authors: Stefanie R. Bailey, Sonika Vatsa, Rebecca C. Larson, Amanda A. Bouffard, Irene Scarfò, Michael C. Kann, Trisha R. Berger, Mark B. Leick, Marc Wehrli, Andrea Schmidts, Harrison Silva, Kevin A. Lindell, Ashley Demato, Kathleen M.E. Gallagher, Matthew J. Frigault, Marcela V. Maus
Journal: Blood Cancer Discovery (2021)

Abstract Chimeric antigen receptor (CAR) T cells induce impressive responses in patients with hematologic malignancies but can also trigger cytokine release syndrome (CRS), a systemic toxicity caused by activated CAR T cells and innate immune cells. Although IFNγ production serves as a potency assay for CAR T cells, its biologic role in conferring responses in hematologic malignancies is not established. Here we show that pharmacologic blockade or genetic knockout of IFNγ reduced immune checkpoint protein expression with no detrimental effect on antitumor efficacy against hematologic malignancies in vitro or in vivo. Furthermore, IFNγ blockade reduced macrophage activation to a greater extent than currently used cytokine antagonists in immune cells from healthy donors and serum from patients with CAR T-cell–treated lymphoma who developed CRS. Collectively, these data show that IFNγ is not required for CAR T-cell efficacy against hematologic malignancies, and blocking IFNγ could simultaneously mitigate cytokine-related toxicities while preserving persistence and antitumor efficacy. Significance: Blocking IFNγ in CAR T cells does not impair their cytotoxicity against hematologic tumor cells and paradoxically enhances their proliferation and reduces macrophage-mediated cytokines and chemokines associated with CRS. These findings suggest that IFNγ blockade may improve CAR T-cell function while reducing treatment-related toxicity in hematologic malignancies. See interview with Stefanie R. Bailey, PhD, recipient of the 2023 Blood Cancer Discovery Award for Outstanding Journal Article: https://vimeo.com/847433865 See related content by McNerney et al., p. 90 (17). This article is highlighted in the In This Issue feature, p. 85
Analysis of Association of Radiation Therapy With Risk of Adverse Events in Patients Receiving Immunotherapy Using Pooled Trial Data Matched by Propensity Score—Reply
Authors: Chana Weinstock, Anup Amatya, Julia A. Beaver
Journal: JAMA Oncology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
177P Low HER2 expression does not influence prognosis in metastatic triple-negative breast cancer: Results from an international, multicenter analysis coordinated by the Austrian Group Medical Tumor Therapy (AGMT)
Authors: S.P. Gampenrieder, V. Dezentjé, M. Lambertini, A. de Nonneville, M. Marhold, F. Le Du, C. Saavedra Serrano, D. Alpuim Costa, E. Blondeaux, L. Del Mastro, F. Bertucci, A. Gonçalves, R. Bartsch, A. Deleuze, A. Cortés Salgado, M. Vitorino, C. Tinchon, L. Pecen, G. Rinnerthaler, R. Greil
Journal: Annals of Oncology (2022)
TO STUDY THE ACIDIFICATION PATTERN IN GASTROESOPHAGEAL REFLUX DISEASE PATIENTS WITH INEFFECTIVE ESOPHAGEAL MOTILITY ON AMBULATORY TWENTY FOUR HOUR PH IMPEDANCE STUDY
Authors: N. Singla, A.P. Singh, P. Inavolu, R. Kalapala
Journal: Endoscopy (2022)

Aims Five different acidification patterns have been reported in Achalasia cardia patients, who have reflux symptoms post endoscopic or surgical myotomy. These patient have ineffective motility (IEM) with acid fermentation as predominant acidification pattern on twenty hour pH impedance study. We describe the predominant acidification pattern in GERD patients with IEM as compared to those with normal esophageal motility (NEM).
IMPROVING USABILITY OF AI SYSTEMS FOR POLYP DETECTION BY RECOGNIZING DIFFERENT INTERVENTIONS DURING COLONOSCOPY
Authors: T. Lux, J. Troya, M. Brand, A. Meining, A. Hann
Journal: Endoscopy (2022)

Aims Artificial intelligence for polyp detection systems (CADe) highlight regions such as colorectal polyps and are useful in fully insufflated colon lumen. However, CADe generate a significant number of false positive (FP) activations when performing interventions such as polypectomies due to the introduction of snare or biopsy forceps. These bounding boxes have the potential to disturb the examiner’s work.
THE EFFECT OF ORAL SIMETHICONE IN A BOWEL PREPARATION IN A COLORECTAL CANCER SCREENING COLONOSCOPY SETTING: AN ENDOSCOPIST-BLINDED RANDOMIZED CONTROLLED TRIAL INTERIM ANALYSIS
Authors: M. João, S. Alves, M. Areia, L. Elvas, D. Brito, S. Saraiva, A.T. Cadime
Journal: Endoscopy (2022)

Aims Current ESGE guideline suggests adding oral simethicone to bowel preparation for colonoscopy. However, its effect on key quality indicators for screening colonoscopy remains unclear. The primary aim was to assess the rate of adequate bowel preparation regarding bubbles, in split-dose high-volume polyethylene glycol (PEG), with or without simethicone. Secondary aims included adenoma detection rate (ADR), caecal intubation rate (CIR), intraprocedural use of simethicone and patient’s compliance.
ENDOSCOPIC RESECTION OF COMPLEX SUPERFICIAL COLORECTAL LESIONS IN A LOW VOLUME CENTER: TECHNIQUES, SAFETY AND EFFECTIVENESS
Authors: R. Muñoz González, E. Resina, J. Escobar Ortiz, A. Ezquerra Duran, C. Santander Vaquero, P. Miranda García
Journal: Endoscopy (2022)

Aims The aim of our study was to evaluate the endoscopic management of complex colorectal lesions in a low volume center. We assessed the safety and effectiveness of each treatment modality.
POSSIBLY THE OLDEST KNOWN PATIENT TO HAVE EUS-GUIDED GASTROJEJUNOSTOMY TO ALLEVIATE DUODENAL OBSTRUCTION
Authors: M. Lajin
Journal: Endoscopy (2022)

A 98-year-old female presented with vomiting, and weight loss. CT showed duodenal obstruction, duodenal diverticula, a ureteral mass, and bilateral hydronephrosis.
VANEK’S TUMOR AS A RARE CAUSE OF DYSPEPTIC SYMPTOMS IN A WOMAN WITH PRIMARY BILIARY CHOLANGITIS: A CASE REPORT
Authors: R. Pellegrino, I. Panarese, N. De Gennaro, P. Ciamarra, K. Priadko, L. Granata, G. Palladino, G. Scidà, A. Facchiano, R. Franco, M. Romano, A.G. Gravina
Journal: Endoscopy (2022)

Aims Vanek's Tumor is a rare mesenchymal gastrointestinal tumor. Different locations have been described and it is generally considered a benign lesion and characterized as a solitary/submucosal polypoid/nodular lesion. It's characterized by a hypocellular population, generally consisting of spindle-like cells, with soft ovoid nuclei, with little eosinophilic cytoplasm. We present a case of Vanek's Tumor.
ESOPHAGEAL STRICTURE SECONDARY TO A LARGE CIRCUMFERENTIAL SQUAMOUS LESION REMOVED BY MULTI-TUNNEL ENDOSCOPIC SUBMUCOSAL DISSECTION
Authors: E. Rodríguez de Santiago, B. Peñas García, S. Parejo Carbonell, A. García García de Paredes, E. Vazquez-Sequeiros, A. Albillos Martínez
Journal: Endoscopy (2022)

A 56-year-old female presented with food impaction. From 16 to 29 cm from the incisors, we visualized a circumferential IIb lesion that prevented the passage of the conventional gastroscope. We made a first submucosal tunnel up to 29 cm from the incisors. Submucosal dissection of the stenotic area (fibrotic and highly vascularised) allowed subsequent access to the distal margin so that we could carry out the distal circumferential incision. We then performed two additional parallel submucosal tunnels. We used traction (clip+thread) to facilitate dissection of the intertunnel submucosa. Size: 130x30mm. Histology:pT1a squamous cell carcinoma with lymphovascular invasion.
PROPOFOL TARGET-CONTROLLED INFUSION (TCI) BY GASTROENTEROLOGISTS FOR ENDOSCOPIC PROCEDURES: AN ANALYSIS OF PATIENT SAFETY AND SATISFACTION
Authors: F.V. Mandarino, L. Fanti, A. Barchi, P. Biamonte, F. Azzolini, D. Esposito, E. Viale, L. Massimino, S. Danese
Journal: Endoscopy (2022)

Aims The aim of the study is to assess the complication rate and patient satisfaction after gastrointestinal endoscopic procedures (excluding surgical endoscopy), with sedation regimen of propofol target-controlled infusion (TCI) administered by gastroenterologist.
SAFETY AND EFFICACY OF ENDOSCOPIC ULTRASOUND GUIDED LIVER BIOPSY (EUS–LB): AN INITIAL EXPERIENCE FROM TERTIARY CARE CENTER IN INDIA
Authors: H. Gadhikar, A. Gandhi, S. Palnitkar, S. Bhagwat, S. Biradar, J. Ansari, H. Raina, R. Pujari, H. Bapaye, A. Bapaye
Journal: Endoscopy (2022)

Aims Liver biopsy(LB) – gold standard for evaluation of liver disorders. Traditional techniques–percutaneous(PCLB)/trans-jugular(TJLB)–inherent limitations/risks. TJLB-preferred in coagulopathy, expensive with limited availability. Endoscopic ultrasound guided liver biopsy(EUS-LB)–recently described, promising results. Study evaluates safety and efficacy of EUS-LB in undiagnosed liver disorders.
232TiP Early acupuncture treatment of vasomotor symptoms and sleep disorders in breast cancer LHRHa induced menopause: AcuFLASH Study
Authors: C. Maggiore, A. Di Micco, M.M. Rossi, A. Filippone, C. Rossi, L. Forcina, D. Giannarelli, R. Masetti, A. Fabi, S. Magno
Journal: Annals of Oncology (2022)
A PROPENSITY MATCHED RETROSPECTIVE STUDY ON PREOPERATIVE BILIARY DRAINAGE IN PATIENTS WITH RESECTABLE PERIHILAR CHOLANGIOCARCINOMA: METAL BEATS PLASTIC STENTS?
Authors: D.M. de Jong, L.E. Nooijen, T.M. Gilbert, E. Braunwarth, M. Ninkovic, F. Primavesi, H.Z. Malik, N. Stern, R. Sturgess, J.I. Erdmann, R.P. Voermans, M.J. Bruno, B. Groot Koerkamp, L.M. van Driel
Journal: Endoscopy (2022)

Aims Adequate preoperative biliary drainage (PBD) is important in patients with resectable perihilar cholangiocarcinoma (pCCA). Currently, Uncovered self-expanding metal stents (SEMS) are not recommended due to potential difficult surgical removal. However, SEMS have proven their advantage in the palliative setting showing a much longer patency and even survival. The aim of this study is to compare the efficacy of PBD with SEMS versus plastic stents (PS) in relation to surgical outcome in resectable pCCA patients.
SINGLE-USE DUODENOSCOPES IN COMPLEX PROCEDURES
Authors: G. Valerii, S. Longo, R. Nunziata, C. Cellini, C. Barbera
Journal: Endoscopy (2022)

Aims The duodenoscope is a complex instrument with unique mechanical features incorporated at the distal tip that creates hard-to-reach areas that make optimal mechanical cleaning and disinfection difficult.
RISK FACTORS FOR EARLY FAILURE OF PERORAL ENDOSCOPIC MYOTOMY (POEM) IN ACHALASIA: A RETROSPECTIVE MULTICENTER STUDY
Authors: B. Vauquelin, A. Berger, M. Pioche, M. Barret, T. Wallenhorst, E. Coron, S. Roman, S. Chaussade, L. Queneherve, T. Ponchon, R. Olivier, F. Zerbib
Journal: Endoscopy (2022)

Aims The aims of our study were to determine the early failure rate of POEM and to identify predictive risk factors.
SEX SPECIFIC DIFFERENCES IN COLORECTAL CANCER MORTALITY AFTER SCREENING COLONOSCOPY
Authors: E. Waldmann, L. Jiricka, J. Zessner-Spitzenberg, B. Majcher, L.-M. Rockenbauer, D. Penz, M. Trauner, M. Ferlitsch
Journal: Endoscopy (2022)

Aims The prevalence and number needed to screen of colorectal adenomas are comparable between men aged 45 to 49 years and women aged 55 to 59 years. The aim of this study was to determine sex specific differences in colorectal cancer mortality and estimate the association with adenomas and high-risk polyps at screening colonoscopy.