AB0753 ASSESSMENT OF SLEEP PROBLEMS IN PATIENTS WITH KAWASAKI DISEASE: A SURVEY-BASED STUDY
Authors: S. Tharwat
Journal: Annals of the Rheumatic Diseases (2021)

Background: Kawasaki disease (KD) is a type of vasculitis that affects mainly medium and small arteries,especially the coronary arteries (1).It mainly affects children under the age of five (2).Sleep disturbances are more prevalent among medically ill children and adults and may have a negative impact on their health related quality of life (3, 4).To the best of our knowledge,sleep problems have not previously studied in KD patients. Objectives: This study aimed to investigate sleep problems, sleep disturbances and the relation between sleep problems and clinical manifestations among patients with KD. Methods: A cross-sectional study was performed using a written survey. Participants were invited through social media groups including patients and parents of children with KD. The survey included questions about demographic data, KD manifestations, disease duration and treatment received for management of the disease. Children’s Sleep Habits Questionnaire (33-item version) was also included in the survey (5). Results: There was a total of 262 survey participants (130 KD and 132 age- and sex matched healthy controls). There was no significant difference in the frequency of clinically significant sleep disturbance between patients with KD and healthy controls. However, the total sleep score was significantly higher in KD patients than health controls (p&lt;.001).Total sleep duration was significantly higher in patients with KD (4.94±1.88 vs 3.74 ±1.14 hr, p&lt;.001).Additionally KD patients had significantly higher scores regarding sleep onset delay (p=.001),night wakings (p&lt;.001),parasomnias (p&lt;.001) and sleep disordered breathing (p&lt;.001) when compared to healthy controls.KD Patients who manifested with chronic heart disease or lethargy had significantly higher sleep score than patients without (p=.015,.039 respectively). Conclusion: This study showed that patients with KD had more sleep disturbance than their healthy peers. The presence of either chronic heart disease or lethargy is associated with poor sleep quality.This study highlights the need for assessment of sleep disorders in KD patients. References: [1]Hedrich CM, Schnabel A, Hospach T. Kawasaki Disease. Front Pediatr. 2018;6:198-. [2]Singh S, Gupta MK, Bansal A, Kumar RM, Mittal BR. A comparison of the clinical profile of Kawasaki disease in children from Northern India above and below 5 years of age. Clinical and experimental rheumatology. 2007;25(4):654-7. [3]van Golde EG, Gutter T, de Weerd AW. Sleep disturbances in people with epilepsy; prevalence, impact and treatment. Sleep medicine reviews. 2011;15(6):357-68. [4]Roehrs T, Diederichs C, Gillis M, Burger AJ, Stout RA, Lumley MA, et al. Nocturnal sleep, daytime sleepiness and fatigue in fibromyalgia patients compared to rheumatoid arthritis patients and healthy controls: a preliminary study. Sleep medicine. 2013;14(1):109-15. [5]Silva FG, Silva CR, Braga LB, Serrão Neto A. Portuguese Children’s Sleep Habits Questionnaire-validation and cross-cultural comparison. Jornal de pediatria. 2014;90(1):78-84. Disclosure of Interests: None declared