tbuckley/cabot-search huggingface dataset:
Endoscopy International Open – recently published
Journal: Endoscopy (2020)

Comment on:Electrochemotherapy for colorectal cancer using endoscopic electroporation: a phase 1 clinical studyEndosc Int Open 2020; 08(02): E124-E132DOI: 10.1055/a-1027-6735Comment on:Anti-reflux mucosal ablation (ARMA) as a new treatment for gastroesophageal reflux refractory to proton pump inhibitors: a pilot studyEndosc Int Open 2020; 08(02): E133-E138DOI: 10.1055/a-1031-9436Comment on:Antireflux mucosectomy band in treatment of refractory gastroesophageal reflux disease: a pilot study for safety, feasibility and symptom controlEndosc Int Open 2020; 08(02): E147-E154DOI: 10.1055/a-1038-4012
Abstract P150: Linkage Program to Identify Siblings from a CARDIAC Risk Factor Registry
Authors: Lee A Pyles, Charles J Mullett, Christa Lilly, William A Neal
Journal: Circulation (2017)

Introduction: The Coronary Artery Risk Detection in Appalachian Communities (CARDIAC) Project gathers anthropometric, BP and lipid data from fifth graders in West Virginia in the past 18 y. 60,403 children had LDL cholesterol and we found 5259 sets of siblings by direct match on mothers first and last name. The suggestion that more sibships could be identified prompted evaluation of Link Plus software from Centers for Disease Control (CDC) to improve matching. Methods: LinkPlus generates potential matches via a probabilistic algorithm that allows relative weighting of multiple factors such as first and last name. For our purposes the deduplication rather than matching algorithm was run using mother’s first and last name using the NYSIIS (New York State Identification and Intelligence System) phonetic schema to avoid creating multiple many-to-many relationships that were difficult to analyze. Additional variables considered included county, street address, telephone, fathers first and last name, school. Subject last name was used as a blocking variable. Results: 7602 matched siblings were generated by the program that determined a probability score ranging from 61.3 to cut off at 15; few matches were observed below this level. The figure demonstrates exponential decay beginning at a probability score of 26 with 95% accuracy at 25.5. 6827 pairs were included at that level including 6824 matched pairs and only 3 false positive pairs. Partial matches (n = 61) likely are half sibs including exact match of telephone and/or street but only one parent matching. Child surname was not used in the algorithm. Typographical errors were accounted by Link Plus. Lipid correlations were similar to those found with excel but more robust. Conclusion: The Link Plus record matching program from CDC is able to successfully determine sibships with increased sensitivity compared with a direct match from a sorted excel file. The program was able to identify likely sibs and half-sibs plus avoid non-match due to minor typo errors in the analyzed fields.
Extending the scope of nursing practice. A report of the Secretary's Committee to study extended roles for nurses
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Errors in a Supplement
Journal: JAMA Network Open (2022)

Martin R. Weiser, MD; Joanne F. Chou, MPH; Ajaratu Keshinro, MD; William C. Chapman Jr, MD; Philip S. Bauer, MD; Matthew G. Mutch, MD; Parag J. Parikh, MD; Andrea Cercek, MD; Leonard B. Saltz, MD; Marc J. Gollub, MD; Paul B. Romesser, MD; Christopher H. Crane, MD; Jinru Shia, MD; Arnold J. Markowitz, MD; Julio Garcia-Aguilar, MD, PhD; Mithat Gönen, PhD; Colorectal Cancer Disease Management Team of Memorial Sloan Kettering Cancer Center; Fiyinfolu Balogun; David Bates; Delia Calo; Louise Connell; John Cuaron; Avni Desai; Imane El Dika; Maria El Homsi; David Faleck; J. Louis Fuqua III; Karuna Ganesh; Hans Gerdes; Zoe Goldberg; Jennifer Golia Pernicka; Carla Hajj; Jaclyn Hechtman; Natally Horvat; Dennis Hsu; Sidra Javed-Tayyab; Nancy Kemeny; Jia Li; Emmy Ludwig; Robin Mendelsohn; Parisa Momtaz; Garrett Nash; Makoto Nishimura; Maliha Nusrat; Emmanouil Pappou; Viktoriya Paroder; Philip Paty; Iva Petkovska; Nitya Raj; Diane Reidy; Marsha Reyngold; Michael Roehrl; Mark Schattner; Juan Schvartzman; Neil Segal; Armin Shahrokni; Marina Shcherba; Moshe Shike; J. Joshua Smith; Zsofia Stadler; Ryan Sugarman; Efsevia Vakiani; Iris Wei; Maria Widmar; Elizabeth Won; Abraham Wu; Rona Yaeger; Alice Zervoudakis; Melissa Zinovoy
Books Received
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Radioimmunotherapy Targeting Delta-like Ligand 3 in Small Cell Lung Cancer Exhibits Antitumor Efficacy with Low Toxicity
Authors: Kathryn M. Tully, Salomon Tendler, Lukas M. Carter, Sai Kiran Sharma, Zachary V. Samuels, Komal Mandleywala, Joshua A. Korsen, Avelyn Mae Delos Reyes, Alessandra Piersigilli, William D. Travis, Triparna Sen, Nagavarakishore Pillarsetty, John T. Poirier, Charles M. Rudin, Jason S. Lewis
Journal: Clinical Cancer Research (2022)

Abstract Purpose: Small cell lung cancer (SCLC) is an exceptionally lethal form of lung cancer with limited treatment options. Delta-like ligand 3 (DLL3) is an attractive therapeutic target as surface expression is almost exclusive to tumor cells. Experimental Design: We radiolabeled the anti-DLL3 mAb SC16 with the therapeutic radioisotope, Lutetium-177. [177Lu]Lu-DTPA-CHX-A”-SC16 binds to DLL3 on SCLC cells and delivers targeted radiotherapy while minimizing radiation to healthy tissue. Results: [177Lu]Lu-DTPA-CHX-A”-SC16 demonstrated high tumor uptake with DLL3-target specificity in tumor xenografts. Dosimetry analyses of biodistribution studies suggested that the blood and liver were most at risk for toxicity from treatment with high doses of [177Lu]Lu-DTPA-CHX-A”-SC16. In the radioresistant NCI-H82 model, survival studies showed that 500 μCi and 750 μCi doses of [177Lu]Lu-DTPA-CHX-A”-SC16 led to prolonged survival over controls, and 3 of the 8 mice that received high doses of [177Lu]Lu-DTPA-CHX-A”-SC16 had pathologically confirmed complete responses (CR). In the patient-derived xenograft model Lu149, all doses of [177Lu]Lu-DTPA-CHX-A”-SC16 markedly prolonged survival. At the 250 μCi and 500 μCi doses, 5 of 10 and 7 of 9 mice demonstrated pathologically confirmed CRs, respectively. Four of 10 mice that received 750 μCi of [177Lu]Lu-DTPA-CHX-A”-SC16 demonstrated petechiae severe enough to warrant euthanasia, but the remaining 6 mice demonstrated pathologically confirmed CRs. IHC on residual tissues from partial responses confirmed retained DLL3 expression. Hematologic toxicity was dose-dependent and transient, with full recovery within 4 weeks. Hepatotoxicity was not observed. Conclusions: Together, the compelling antitumor efficacy, pathologic CRs, and mild and transient toxicity profile demonstrate strong potential for clinical translation of [177Lu]Lu-DTPA-CHX-A”-SC16.
Response to Comment on Lee et al. Sodium–Glucose Cotransporter 2 Inhibitors and Risk of Retinal Vein Occlusion Among Patients With Type 2 Diabetes: A Propensity Score–Matched Cohort Study. Diabetes Care 2021; 44:2419–2426
Authors: Min-Kyung Lee, Kyungdo Han, Hyuk-Sang Kwon
Journal: Diabetes Care (2022)
Development of hot-melt extruded drug/polymer matrices for sustained delivery of meloxicam
Authors: Yun-Chu Chen, Dana E. Moseson, Coralie A. Richard, Monica R. Swinney, Sarena D. Horava, Kaoutar Abbou Oucherif, Amy L. Cox, Eric D. Hawkins, Yongzhe Li, Daniel F. DeNeve, Joshua Lomeo, Aiden Zhu, L. Tiffany Lyle, Eric J. Munson, Lynne S. Taylor, Kinam Park, Yoon Yeo
Journal: Journal of Controlled Release (2022)
The COVID-19 infodemic
Authors: None The Lancet Infectious Diseases
Journal: The Lancet Infectious Diseases (2020)

"We're not just fighting a pandemic; we're fighting an infodemic," said Tedros Adhanom Ghebreyesus, WHO's director-general, at the 2020 Munich Security Conference. Fake news, misinformation, and conspiracy theories have become prevalent in the age of social media and have skyrocketed since the beginning of the COVID-19 pandemic. This situation is extremely concerning because it undermines trust in health institutions and programmes. On June 29, WHO formally began the conversation on the global effects and management of infodemics with its 1st Infodemiology Conference that convened international experts from diverse scientific and political backgrounds.
Increased 68Ga-FAPI Uptake in Facet Joint Osteoarthritis in a Patient With Esophageal Cancer
Authors: Xiao Yang, Zhouxiang You, Weidong Gong, Yue Chen, Huipan Liu
Journal: Clinical Nuclear Medicine (2022)

Abstract A 69-year-old man presented with newly diagnosed esophageal cancer was enrolled in our clinical trial of 68 Ga-FAPI PET/CT study in tumors. Increased tracer uptake was noted in esophageal cancer. In addition, the facet joint osteoarthritis of T7/8 vertebrae also revealed elevated 68 Ga-FAPI uptake.
NOD‐like receptor protein 3 activation causes spontaneous inflammation and fibrosis that mimics human NASH
Authors: David M. Calcagno, Angela Chu, Susanne Gaul, Nika Taghdiri, Avinash Toomu, Aleksandra Leszczynska, Benedikt Kaufmann, Bettina Papouchado, Alexander Wree, Lukas Geisler, Hal M. Hoffman, Ariel E. Feldstein, Kevin R. King
Journal: Hepatology (2022)

Abstract Background and Aims The NOD‐like receptor protein 3 (NLRP3) inflammasome is a central contributor to human acute and chronic liver disease, yet the molecular and cellular mechanisms by which its activation precipitates injury remain incompletely understood. Here, we present single cell transcriptomic profiling of livers from a global transgenic tamoxifen‐inducible constitutively activated Nlrp3 A350V mutant mouse, and we investigate the changes in parenchymal and nonparenchymal liver cell gene expression that accompany inflammation and fibrosis. Approach and Results Our results demonstrate that NLRP3 activation causes chronic extramedullary myelopoiesis marked by myeloid progenitors that differentiate into proinflammatory neutrophils, monocytes, and monocyte‐derived macrophages. We observed prominent neutrophil infiltrates with increased Ly6g HI and Ly6g INT cells exhibiting transcriptomic signatures of granulopoiesis typically found in the bone marrow. This was accompanied by a marked increase in Ly6c HI monocytes differentiating into monocyte‐derived macrophages that express transcriptional programs similar to macrophages of NASH models. NLRP3 activation also down‐regulated metabolic pathways in hepatocytes and shifted hepatic stellate cells toward an activated profibrotic state based on expression of collagen and extracellular matrix regulatory genes. Conclusions These results define the single cell transcriptomes underlying hepatic inflammation and fibrosis precipitated by NLRP3 activation. Clinically, our data support the notion that NLRP3‐induced mechanisms should be explored as therapeutic target in NASH‐like inflammation.
MEASUREMENTS OF CHICAGO SCHOOL CHILDREN.
Authors: W. S. CHRISTOPHER
Journal: JAMA (1900)

<h3>RELATION OF INTELLECTUAL AND PHYSICAL CONDITIONS.</h3> As a result of his examination of 33,500 school children in St. Louis, in 1892, Dr. W. Townsend Porter concluded that there is a physical basis of precocity; that dull children are lighter, and precocious children heavier than the average child; that mediocrity of mind is associated with mediocrity of physique. At the outset of my observations I determined to reinvestigate Porter's proposition, and have to say that such facts as we have been able to collect go to confirm it. There were met, in the course of these examinations, 503 children, aged 12, who were distributed throughout the grades from the second to the eighth, inclusive. A few were also found in the high schools. The physical peculiarities of these children, in each of the points examined is set forth graphically in the following charts. In these figures the averages of each particular
South Staffordshire General Hospital Wolverhampton
Authors: V. Jackson
Journal: BMJ (1861)

jBRIXISH;a MEDIOAL JOURNAL.intestinal fever is compounded of two distinct ele- ments, it is equally certain that what is gained on the one hand, in the way of predisposition, is more thani lost on the other by the extinction or dispersion of the poison through the operation of natural causes.So that the total effect, far from being in excess ,of the full power of the specific poison which the sewer receives, falls, in reality, immeasurably below 'it.As this, however, is a point of speculative in- terest onily, it is one on which I need not dwell fur- ther here.,jIlustratirons
Abstract P280: Neighborhood Social Cohesion Does Not Moderate the Association of Neighborhood Walkability With Aerobic Physical Activity in Latino Adults: The National Health Interview Survey (NHIS) 2015
Authors: Rosenda Murillo, Layton M Reesor, Daphne C Hernandez, Ezemenari M Obasi
Journal: Circulation (2018)

Introduction: Neighborhood walkability and neighborhood social cohesion have been shown to contribute to physical activity. However, limited research has examined neighborhood social cohesion as a moderator in the association between neighborhood walkability and aerobic physical activity among Latino adults. We examined associations of neighborhood walkability using measures assessing built environment and safety, with meeting the aerobic activity guideline among a large nationally representative diverse sample of Latino adults. Methods: We used cross-sectional data from 4,765 NHIS 2015 Latino participants 18 years of age and older. Neighborhood walkability was assessed based on self-reported measures of built environment (e.g., presence of sidewalks, presence of paths/trails) and neighborhood safety (e.g., presence of traffic, crime). A neighborhood walkability score was created by combining the built environment and neighborhood safety items, with a higher score indicating higher walkability. Aerobic activity was categorized as meeting versus not meeting the aerobic activity guideline, based on 2008 Physical Activity Guidelines for Americans . Neighborhood social cohesion was measured based on self-reported items assessing perceived neighborhood social cohesion. Survey logistic regression was used to compute odds ratios [OR] and 95% confidence intervals [CI], with covariates adjusting for age, sex, education, acculturation, and neighborhood social cohesion. Effect modification by neighborhood social cohesion was tested by inclusion of a neighborhood walkability and neighborhood social cohesion interaction term. Results: On average the sample was 44 years old, 44% were male, 36% had less than a high school education, and 58% were foreign-born. After adjusting for age, sex, education, and acculturation, a one-unit higher neighborhood walkability score was associated with significantly higher odds of meeting the aerobic physical activity guideline (OR: 1.08; 95% CI: 1.05, 1.11), relative to not meeting the aerobic activity guideline. After adding neighborhood social cohesion to the adjusted model, the association between neighborhood walkability and meeting the aerobic activity guideline was slightly attenuated, but remained significant (OR: 1.07; 95% CI: 1.03, 1.11). Results from the effect modification test indicated that the neighborhood walkability and neighborhood social cohesion interaction term was not significant. Conclusions: These findings suggest that neighborhood walkability contributes to meeting the aerobic physical activity guideline among Latino adults. However, neighborhood social cohesion does not moderate the association between neighborhood walkability and meeting the aerobic activity guideline.
Hb Johnstown [β109 (G11) Val→Leu]: Second case described and associated for the first time with β0‐thalassemia in two Spanish families
Authors: P. Ropero, A. Villegas, A.F. González, E. Anguita, J. Sánchez, D.L. Carreño, B. Arrizabalaga, L. Atuxta
Journal: American Journal of Hematology (2000)

Hb Johnstown, a high oxygen affinity hemoglobin, was identified in four members from two unrelated Spanish families with erythrocytosis and left-shifted hemoglobin–oxygen dissociation curve. This hemoglobin variant, electrophoretically silent, was analyzed by reverse-phase high-performance liquid chromatography, and the mutation was characterized at the DNA level by β gene sequencing. In one of these families, two members are affected with Hb Johnstown in association with β0-thalassemia. In these cases the erythrocytosis and low values for P50 due to Hb Johnstown remain in spite of the β-thalassemia. Am. J. Hematol. 65:298–301, 2000. © 2000 Wiley-Liss, Inc.
Hospitalists and the Costs and Outcomes of Hospital Care
Journal: Annals of Internal Medicine (2002)

Summaries for Patients3 December 2002Hospitalists and the Costs and Outcomes of Hospital CareSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-11-200212030-00002 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?American doctors have traditionally spent part of their day seeing patients in their offices and part of their day seeing patients in the hospital. However, many hospitals have begun to use doctors called hospitalists. Hospitalists spend a large portion of their time taking care of hospitalized patients. The concept of hospitalists was developed to improve quality and reduce costs. Because of increases in the hospital patients' level of illness and the specialized nature of hospital care, it is difficult for doctors to split their time between the outpatient ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Effects of Physician Experience on Costs and Outcomes on an Academic General Medicine Service: Results of a Trial of Hospitalists.” It is in the 3 December 2002 issue of Annals of Internal Medicine (volume 137, pages 866-874). The authors are D Meltzer, WG Manning, J Morrison, MN Shah, L Jin, T Guth, and W Levinson.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffects of Physician Experience on Costs and Outcomes on an Academic General Medicine Service: Results of a Trial of Hospitalists David Meltzer , Willard G. Manning , Jeanette Morrison , Manish N. Shah , Lei Jin , Todd Guth , and Wendy Levinson Metrics 3 December 2002Volume 137, Issue 11Page: I-25KeywordsAcademic medicineHospital medicineHospitalistsLearning curvesOutpatient clinicsPatients ePublished: 3 December 2002 Issue Published: 3 December 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Lancet, London
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal