tbuckley/cabot-search huggingface dataset:
Detection of Breast Cancer
Authors: Martin B. Flamm
Journal: JAMA (1987)

<h3>To the Editor.—</h3> In your Sept 12, 1986, issue, Dr Vorherr<sup>1</sup>makes several statements concerning detection of breast cancer that I believe are erroneous. In his letter, he states that "physicians already order mammograms liberally or excessively because of fears of overlooking carcinoma and facing possible litigation." In fact, the opposite is true. A recurrent theme in medical negligence cases concerning failure to diagnose breast cancer is that of failure to order mammography at appropriate or suggested intervals.<sup>2</sup> Dr Vorherr also claims that breast aspiration is "capable of reliably diagnosing cancer" and encourages performing this procedure. In fact, there is considerable debate as to the accuracy of this procedure. A Massachusetts court recently ruled in favor of a woman who successfully sued her primary care physician even though the physician had relied on a negative needle biopsy of a breast lump, later discovered to be malignant.<sup>3</sup>If
Intensive Care Unit Admission and Mortality Among Medicare Beneficiaries With Pneumonia
Authors: Andrea Rossi Zadra, Nicoletta Barzaghi, Cinzia Di Novi
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Influence of dobutamine on regional myocardial blood flow and ventricular performance during acute and chronic myocardial ischemia in dogs.
Authors: J TWillerson, IHutton, J TWatson, M RPlatt, G HTempleton
Journal: Circulation (1976)

The data from this study document that dobutamine is a powerful inotropic agent in anesthetized dogs with acute myocardial ischemia and in awake, unsedated ones with chronic myocardial infarction. Dobutamine significantly increases heart rate at relatively small doses in anesthetized dogs with acute myocardial ischemia but considerably larger amounts of dobutamine are required to significantly increase heart rate in awake, unsedated dogs with myocardial infarction. Dobutamine also significantly increases regional myocardial blood flow to all areas of the heart at 20mug/kg/min in both anesthetized dogs with acute myocardial ischemia and awake, unsedated ones with myocardial infarction. However, in anesthetized dogs 20mug/kg/min of dobutamine significantly increases epicardial ST-segment elevation during acute myocardial ischemia. Propranolol prevents the inotropic and chronotropic effects of dobutamine in both anesthetized and awake, unsedated dogs. This study suggests that during experimental acute myocar...
Shall The Journal be Removed to Washington?
Authors: B. S. Woodworth
Journal: JAMA (1891)

<h3>To the Editor:</h3> —The question of the removal ofThe Journalfrom Chicago to Washington, which is now being discussed by many physicians in every part of the United States, is, to my mind, clearly opposed by a large majority of the members of the Association—and I, for one, say, Let it remain where it is, a place which is approved of by the great majority, as I firmly believe. Fort Wayne, Ind., March 28, 1891.
Women in general practice
Authors: S. Shaw
Journal: BMJ (1992)

future.The development of a coherent strategy across all sectors following a health lead has been shown to be possible in Wales.4NHS regions in the United Kingdom may have the option of looking towards Brussels rather than Whitehall for health policy in the longer term.The mere suggestion of this may be enough to get Whitehall departments collaborating more effectively to fill "the hole at the centre."
Changes in the radius of curvature of the ventricular septum at end diastole during pulmonary arterial and aortic constrictions in the dog.
Authors: S JDong, E RSmith, J VTyberg
Journal: Circulation (1992)

BACKGROUNDAt end diastole, the position and shape of the ventricular septum depend on the transseptal pressure gradient. It is not clear, however, how the septal radius of curvature changes in response to the gradual change in transseptal pressure gradient during progressive pulmonary arterial constriction (PAC) and aortic constriction (AC).METHODS AND RESULTSIn 11 anesthetized open-chest dogs, the septal radius of curvature was measured from the short-axis two-dimensional echocardiogram, and the transseptal pressure gradient (left ventricular [LV] pressure minus right ventricular [RV] pressure) was calculated from ventricular pressures measured with micromanometers. Seven dogs were studied with both PAC and AC (group 1) and four dogs only with PAC, which was initiated before and after volume loading (group 2). The transseptal pressure gradient decreased during PAC. As the transseptal pressure gradient decreased, the septum shifted continuously leftward with decreases in the LV septum-free wall diameter a...
Aspirin and Cancer Risk
Authors: Theodore M. Brasky, Emily White, Jean Wactawski-Wende
Journal: JAMA Oncology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Endoscopic Submucosal Fistula Diversion (SFED) After Sleeve Gastrectomy: About one Case
Authors: JM Gonzalez, M Barthet
Journal: Endoscopy (2021)

We propose submucosal fistula endoscopic derivation (SFED) in the treatment of refractory fistula. She had two LSG in 2015 hand 2019, complicated by fistula treated by endoscopic drainage. A long fistulous gastro-cutaneious path was persisting, with a permanent purulent flow. The procedure was: creation of two 4 cm sub-mucosal tunnels in each part of the fistula’s orifice; guidewire placement within both tunnels; covered SEMS placement into tunnels.
On the Treatment of Detachment of the Retina
Authors: J. R. Wolfe
Journal: BMJ (1884)

l HAvE thie honiour to ,pre §eiYt to the Aeademy aitiethod dt treatient ~n cases of detachlneit of the retina, an afteetioii wich' has hitherto =n regarded by all oculists as incurable.Vari9us.means, of both nsodidal and surgical treatUnent, have been tried, but have been all' abandoned as unifitted to cope with that disease.As I have fequently Yccbdfd in cnriiug'patieits 6f &dtachmeht of the retiia; I sin d&sifous fJ'IV4iiimitting miiy mode of treatme4n.of: e consideration ofv the 4 nidmy.
Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study.
Authors: H BHubert, MFeinleib, P MMcNamara, W PCastelli
Journal: Circulation (1983)

The relationship between the degree of obesity and the incidence of cardiovascular disease (CVD) was reexamined in the 5209 men and women of the original Framingham cohort. Recent observations of disease occurrence over 26 years indicate that obesity, measured by Metropolitan Relative Weight, was a significant independent predictor of CVD, particularly among women. Multiple logistic regression analyses showed that Metropolitan Relative Weight, or percentage of desirable weight, on initial examination predicted 26-year incidence of coronary disease (both angina and coronary disease other than angina), coronary death and congestive heart failure in men independent of age, cholesterol, systolic blood pressure, cigarettes, left ventricular hypertrophy and glucose intolerance. Relative weight in women was also positively and independently associated with coronary disease, stroke, congestive failure, and coronary and CVD death. These data further show that weight gain after the young adult years conveyed an inc...
Oxytocin, Neural Plasticity, and Social Behavior
Authors: Robert C. Froemke, Larry J. Young
Journal: Annual Review of Neuroscience (2021)

Oxytocin regulates parturition, lactation, parental nurturing, and many other social behaviors in both sexes. The circuit mechanisms by which oxytocin modulates social behavior are receiving increasing attention. Here, we review recent studies on oxytocin modulation of neural circuit function and social behavior, largely enabled by new methods of monitoring and manipulating oxytocin or oxytocin receptor neurons in vivo. These studies indicate that oxytocin can enhance the salience of social stimuli and increase signal-to-noise ratios by modulating spiking and synaptic plasticity in the context of circuits and networks. We highlight oxytocin effects on social behavior in nontraditional organisms such as prairie voles and discuss opportunities to enhance the utility of these organisms for studying circuit-level modulation of social behaviors. We then discuss recent insights into oxytocin neuron activity during social interactions. We conclude by discussing some of the major questions and opportunities in the field ahead.
Adjuvant therapy for intracoronary stents. Investigations in atherosclerotic swine.
Authors: G PRodgers, S TMinor, KRobinson, DCromeens, S CWoolbert, L CStephens, J RGuyton, KWright, G SRoubin, A ERaizner
Journal: Circulation (1990)

Early thrombosis has complicated human stent implantation in several trials. To determine the best anticoagulation/antiplatelet therapy to maintain stent patency after percutaneous transluminal coronary angioplasty, we implanted the flexible balloon-expandable coil stent into the left anterior descending coronary artery of 28 atherosclerotic 8-month-old Hanford miniature swine. Animals were randomly assigned to one of three treatment groups: group A, aspirin (1 mg/kg/day) and dipyridamole (1 mg/kg three times a day); group B, aspirin and dipyridamole (same doses) plus Coumadin (dose required to prolong prothrombin time 1.3-1.5-fold that of normal); and group C, control. Adjuvant therapy was begun 3 days before stenting. Two pigs (one from group A and one from group B) died during implantation, both without thrombosis. Twenty-six animals survived until follow-up angiography and sacrifice at 1 month. No occlusive thrombosis of the stent occurred in survivors. Reduction of the stent lumen diameter was observ...
Surgery for Meniere's disease.
Authors: R F Rohan
Journal: BMJ (1977)

Respiratory side effects of beta-blockers SIR,-I would like to comment on one aspect of the hazards of beta-blockers (leading article, 26 February, p 529)-namely, their use in patients with airways obstruction.It is well known that blockade of beta2 receptors may lead to bronchoconstriction in asthmatics.'This risk is said to be less with the so-called selective beta-blockers, which block predominantely the beta, receptors.My
Effect of in vitro organic nitrate tolerance on relaxation, cyclic GMP accumulation, and guanylate cyclase activation by glyceryl trinitrate and the enantiomers of isoidide dinitrate.
Authors: B MBennett, HSchröder, L DHayward, S AWaldman, FMurad
Journal: Circulation Research (1988)

Previously, it was shown that the D enantiomer of isoidide dinitrate was 10-fold more potent than the L enantiomer and 10-fold less potent than glyceryl trinitrate for stimulating cyclic GMP accumulation and relaxation of isolated rat aorta. In the present study, these organic nitrates were tested for their ability to induce tolerance to organic nitrate-induced relaxation, cyclic GMP accumulation, and guanylate cyclase activation in rat aorta in vitro. To compensate for the differences in vasodilator potency, tolerance was induced by incubating isolated rat aorta with concentrations of organic nitrates 1,000-fold greater than the EC50 for relaxation. Under these conditions, the EC50 for relaxation was increased significantly for each organic nitrate and to a similar degree on subsequent reexposure. These data suggest that the potential for inducing in vitro tolerance to relaxation was the same for the three organic nitrates tested. When activation of soluble guanylate cyclase by these compounds was assess...
COVID-19 Pandemic Sets New Clues on the Transmission Pathways in Kawasaki Disease
Authors: Xavier Rodó, Alejandro Fontal
Journal: JAMA Network Open (2021)

Takuya Hara, MD; Kenji Furuno, MD, PhD; Kenichiro Yamamura, MD, PhD; Junji Kishimoto, PhD; Yumi Mizuno, MD, PhD; Kenji Murata, MD, PhD; Sagano Onoyama, MD, PhD; Ken Hatae, MD, PhD; Megumi Takemoto, MD, PhD; Yoshito Ishizaki, MD, PhD; Shunsuke Kanno, MD, PhD; Kazuo Sato, MD, PhD; Yoshitomo Motomura, MD, PhD; Yasunari Sakai, MD, PhD; Shouichi Ohga, MD, PhD; Mayumi Yashiro, BA; Yoshikazu Nakamura, MD, PhD; Toshiro Hara, MD, PhD
Pseudoejection sound in hypertrophic subaortic stenosis: an echocardiographic correlative study.
Authors: K CSze, P MShah
Journal: Circulation (1976)

Phonoechocardiographic studies were performed in 23 patients with hypertrophic subaortic stenosis. In ten patients a distinct systolic sound was recorded, usually along the lower left sternal border. In eight of these cases the sound was low or medium frequency. Unlike the ejection click of valvular aortic stenosis, the sound began 40-100 msec after the upstroke of the indirect carotid pulse and occurred close to the initial peak of the carotid pulse. This sound, termed pseudoejection sound, was associated with systolic anterior movement (SAM) of the anterior mitral leaflet on the echocardiogram. In all six patients studied with simultaneous phonoechocardiograms, the pseudoejection sound coincided with the sudden halting of SAM of the anterior mitral leaflet. Following provocative maneuvers the sound became louder, and its timing, as well as the sharp halting of SAM of the mitral leaflet, occurred earlier in systole. The pseudoejection sound probably results either from impact of the anterior mitral leafl...
PATHOGENESIS OF CROHN'S DISEASE
Authors: AnjanK Banerjee, TimothyJ Peters, PhilipB James, DavidJ.D Perrins, PhilipF Schofield, N.Y Haboubi, J.F Schved, J.C Gris, A Dubois, A Raffanel, P Aguilar-Martinez
Journal: The Lancet (1989)
Hemodynamic responses to atrial natriuretic factor in nephrectomized rabbits: attenuation of the circulatory consequences of acute volume expansion.
Authors: MVolpe, FVecchione, ACuocolo, GLembo, SPignalosa, MCondorelli, BTrimarco
Journal: Circulation Research (1988)

We investigated the hemodynamic responses to three doses of atrial natriuretic factor [human atrial natriuretic factor-(99-126)] (ANF) in nephrectomized rabbits anesthetized with ketamine and acepromazine. The influence of the different doses of the peptide on the hemodynamic consequences produced by acute volume expansion (0.9% NaCl, 1.4 ml/kg/min for 60 minutes) was also studied. All three dosages of ANF (0.001, 0.01, and 0.2 micrograms/kg/min for 20 minutes) significantly reduced blood pressure. With the lowest dose, the hypotensive effect was associated with reduction in systemic vascular resistance and no significant change in heart rate, stroke volume, central venous pressure, and hematocrit. In contrast, the intermediate and high doses, which resulted in markedly higher plasma levels, caused a significant decrease in heart rate, central venous pressure, and stroke volume; a slight rise in hematocrit; and no change in systemic vascular resistance. Volume expansion produced by saline infusion in an a...
Quantitative angiographic morphology of the coronary artery lesions at risk of thrombotic occlusion.
Authors: YTaeymans, PThéroux, JLespérance, DWaters
Journal: Circulation (1992)

BACKGROUNDCoronary angiography in acute myocardial infarction has revealed complicated atherosclerotic plaque and a high rate of thrombotic occlusion. However, the characteristics of lesions at high risk of subsequent occlusion are not well known.METHODS AND RESULTSIn the present study, the qualitative and quantitative angiographic features of 38 coronary artery lesions that occluded within 3 years to cause an acute myocardial infarction were compared with 64 control segments from the same patients that did not occlude. Compared with control lesions, the lesions that occluded were more likely to have a division branch originating within the stenosis (76% versus 52%, p less than 0.05). The percent lumen diameter reduction was more severe (47.5 +/- 17.8% versus 41 +/- 12.5%, p less than 0.05) and the inflow (21 +/- 10 degrees versus 16 +/- 7 degrees, p less than 0.05) and outflow (20 +/- 10 degrees versus 16 +/- 8 degrees, p less than 0.05) angles of the stenosis were steeper. Time to myocardial infarction ...
Impact Of Trainee Involvement On The Endoscopist Biopsy Rate And Detection Of Premalignant Conditions At Upper Gastrointestinal Endoscopy
Authors: M State, A Voiosu, A Bengus, T Voiosu, RB Mateescu
Journal: Endoscopy (2021)

Aims Validated quality indicators for upper-GI endoscopy are essential in order to provide optimal patient care. Recently, the endoscopist biopsy rate (EBR) has been shown to correlate with increased detection of upper GI premalignant conditions (UPC) [[1]]. We aimed to determine if the EBR rate of the senior endoscopists varied according to trainee involvement in the procedures.
Effects of RANKL inhibition on promoting healing of bone erosion in rheumatoid arthritis using HR-pQCT: a 2-year, randomised, double-blind, placebo-controlled trial
Authors: Ho So, Isaac T Cheng, Sze-Lok Lau, Evelyn Chow, Tommy Lam, Vivian W Hung, Edmund K Li, James F Griffith, Vivian W Lee, Lin Shi, Junbin Huang, Kitty Yan Kwok, Cheuk-Wan Yim, Tena K Li, Vincent Lo, Jolie Lee, Jack Jock-Wai Lee, Ling Qin, Lai-Shan Tam
Journal: Annals of the Rheumatic Diseases (2021)

Objective To evaluate the effects of denosumab on erosion healing at 2–4 metacarpophalangeal (MCP) head as determined by high-resolution peripheral quantitative CT (HR-pQCT) in patients with rheumatoid arthritis (RA) with stable disease. Methods This was a randomised, placebo-controlled, double-blind study. Patients with RA with disease activity score 28 joints (DAS28) ≤5.1 were randomised (1:1) to subcutaneous denosumab 60 mg or placebo once every 6 months for 24 months. The primary outcome was erosion healing at MCP 2–4 on HR-pQCT at 12 months. The effects of denosumab on erosion and joint space parameters on HR-pQCT and radiographs, disease activity and health assessment questionnaire-disability index (HAQ-DI) were also examined. Results At 24 months, HR-pQCT images were analysed in 98 patients. One-third of the patients achieved sustained low disease activity throughout the study. At 12 months, changes in erosion parameters on HR-pQCT were similar between the two groups. At 24 months, new erosions (19% vs 9%, p=0.009) and erosion progression (18% vs 8%, p=0.019) were more common in the placebo group than the denosumab group. Erosion healing was seen in a significantly higher proportion of patients in the denosumab group (20% vs 6%, p=0.045) at 24 months. No significant changes in joint space parameters on HR-pQCT, van der Heijde-Sharp erosion score, DAS28 and HAQ-DI were observed in the two groups at 12 and 24 months. Conclusion Although no differences in erosion parameters were observed at 12 months, denosumab was more efficacious than placebo in erosion repair on HR-pQCT after 24 months. Trial registration number NCT03239080 .
Effects of cellular uncoupling on conduction in anisotropic canine ventricular myocardium.
Authors: C WBalke, M DLesh, J FSpear, AKadish, J HLevine, E NMoore
Journal: Circulation Research (1988)

Experiments were performed on canine superfused ventricular epicardial tissue slices to determine the effects of 1.0-2.0 mM heptanol, an uncoupling agent, on conduction longitudinal and transverse to myocardial fiber orientation. Conduction velocities were measured between proximal and distal pairs of epicardial electrodes oriented transverse and longitudinal to the direction of a conducted wavefront evoked by pacing at a basic cycle length of 2,000 msec from one margin of the tissue before and after the addition of heptanol. In a separate group of tissues, the dual bipolar orthogonal electrode was used to sequentially map epicardial activation at 40 to 45 sites in a 1 cm x 2 cm area before and 30 minutes after the introduction of heptanol. In a third group of tissues, transmembrane potentials were recorded with standard microelectrode techniques to determine the effects of heptanol on action potential characteristics. Heptanol did not significantly effect action potential amplitude or maximum rate of dep...