tbuckley/cabot-search huggingface dataset:
A Randomized Clinical Trial of Attempted Suicide Short Intervention Program versus Crisis Counseling in Preventing Repeat Suicide Attempts: A Two-Year Follow-Up Study
Authors: Petri Arvilommi, Jukka Valkonen, Lars H. Lindholm, Selma Gaily-Luoma, Kirsi Suominen, Outi M. Ruishalme, Marena Kukkonen, Harri Sihvola, Erkki Isometsä
Journal: Psychotherapy and Psychosomatics (2022)

&lt;b&gt;&lt;i&gt;Introduction:&lt;/i&gt;&lt;/b&gt; The Attempted Suicide Short Intervention Program (ASSIP) is a brief psychotherapeutic intervention, and a pivotal study found it to be remarkably effective in reducing repeat suicide attempts. &lt;b&gt;&lt;i&gt;Objective:&lt;/i&gt;&lt;/b&gt; To compare the effectiveness of ASSIP to crisis counseling (CC) in a randomized clinical trial (ISRCTN13464512). &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; Adult patients receiving treatment for a suicide attempt in a Helsinki City general hospital emergency room in 2016–2017 were eligible to participate. We excluded psychotic or likely non-adherent substance-abusing or substance-dependent patients. Eligible patients (&lt;i&gt;n&lt;/i&gt; = 239) were randomly allocated to one of two interventions. (a) ASSIP comprised three visits, including a videotaped first visit, a case formulation, and an individualized safety plan, plus letters from the therapist every 3 months for 1 year, and then, every 6 months for the next year. (b) CC typically involved 2–5 (median 3) face-to-face individual sessions. In addition, all participants received their usual treatment. One and 2 years after baseline, information related to participants’ suicidal thoughts and attempts, and psychiatric treatment received was collected via telephone and from medical and psychiatric records. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; Among randomized patients, two-thirds initiated either ASSIP (&lt;i&gt;n&lt;/i&gt; = 89) or CC (&lt;i&gt;n&lt;/i&gt; = 72), with 73 (82%) completing ASSIP and 58 (81%) CC. The proportion of patients who attempted suicide during the 2-year follow-up did not differ significantly between ASSIP and CC (29.2% [26/89] vs. 35.2% [25/71], OR 0.755 [95% Cl 0.379–1.504]). &lt;b&gt;&lt;i&gt;Conclusions:&lt;/i&gt;&lt;/b&gt; We found no difference in the effectiveness of the two brief interventions to prevent repeat suicide attempts.
NOVEL-1st: Interim Analysis of a Non-Interventional, Multi-Center Observational Study to Assess the Safety and Efficacy of Nilotinib in Newly Diagnosed Patients with Philadelphia Chromosome Positive (Ph+) Chronic Myelogenous Leukemia in Chronic Phase (CML-CP) in Taiwan
Authors: Hwang Wen-Li, Shao-Min Han, Shyuann-Yuh Lin, Ming-Chih Chang, Li-Yuan Bai, Pei-Ching Hsiao, Ching-Yuan Kuo, Yeu-Chin Chen, Ta-Chih Liu, Po-Nan Wang, Jyh-Pyng Gau, Yee-Ming Lee, Fan-Chen Ku, Jih-Luh Tang
Journal: Blood (2018)
Cover Image, Volume 42, Issue 1
Authors: Laura Ling Ying Tan, Quynh‐Thu Le, Nancy Ying Ying Lee, Melvin Lee Kiang Chua
Journal: Cancer Communications (2022)

The cover image is based on the Discussion of Paper JUPITER-02 trial: advancing survival for recurrent metastatic nasopharyngeal carcinoma and next steps by Melvin Chua et al., https://doi.org/10.1002/cac2.12248.
Phil Sokolof fights the 'fatting' of America
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pan-American Medical Congress.
Authors: None G. B. G.
Journal: JAMA (1896)

<h3>To the Editor:</h3> —I expect to attend the Congress as delegate from theAmerican Medical Association. Is it necessary to send my name and fee to the secretary general, City of Mexico? <h3>Answer:</h3> —Send your registration fee, $5 (gold), to Prof. Dr. Van Francisco Bastillos, Calle de Tabuca, No. 7, City of Medico, Republic of Mexico.
ABSTRACTS FROM THE LITERATURE
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phylotranscriptomics Reveals Discordance in the Phylogeny of Hawaiian <i>Drosophila</i> and <i>Scaptomyza</i> (Diptera: Drosophilidae)
Authors: Samuel H Church, Cassandra G Extavour
Journal: Molecular Biology and Evolution (2022)

Island radiations present natural laboratories for studying the evolutionary process. The Hawaiian Drosophilidae are one such radiation, with nearly 600 described species and substantial morphological and ecological diversification. These species are largely divided into a few major clades, but the relationship between clades remains uncertain. Here, we present new assembled transcriptomes from 12 species across these clades, and use these transcriptomes to resolve the base of the evolutionary radiation. We recover a new hypothesis for the relationship between clades, and demonstrate its support over previously published hypotheses. We then use the evolutionary radiation to explore dynamics of concordance in phylogenetic support, by analyzing the gene and site concordance factors for every possible topological combination of major groups. We show that high bootstrap values mask low evolutionary concordance, and we demonstrate that the most likely topology is distinct from the topology with the highest support across gene trees and from the topology with highest support across sites. We then combine all previously published genetic data for the group to estimate a time-calibrated tree for over 300 species of drosophilids. Finally, we digitize dozens of published Hawaiian Drosophilidae descriptions, and use this to pinpoint probable evolutionary shifts in reproductive ecology as well as body, wing, and egg size. We show that by examining the entire landscape of tree and trait space, we can gain a more complete understanding of how evolutionary dynamics play out across an island radiation.
Abstract 125: Perturbation of Mitochondrial Calcium Uniporter Promotes Cardiac Oxidative Stress and Autophagy During Heart Failure
Authors: Sudarsan Rajan, Santhanam Shanmughapriya, Dhanendra Tomar, Zhiwei Dong, Joseph Y Cheung, Peter B Stathopulos, Madesh Muniswamy
Journal: Circulation Research (2017)

Mitochondrial calcium ([Ca 2+ ] m ) is essential for cardiomyocyte viability, and aberration of [Ca 2+ ] m is known to elicit multiple cardiac stress conditions associated with ATP depletion, reactive oxygen species, and mitochondrial permeability transition pore opening, all of which can lead to metabolic stress and the loss of dysfunctional mitochondria by aberrant autophagy. Elucidating the regulatory role of m itochondrial c alcium u niporter (MCU)-mediated [Ca 2+ ] m in modulating cardiac mitochondrial bioenergetics and autophagy has high significance and clinical impact for many pathophysiological processes. [Ca 2+ ] m is exquisitely controlled by the inner mitochondrial membrane uniporter, transporters, regulators and exchangers including MCU, MCUR1, EMRE, MICU1, MICU2 and LETM1. Our recently published findings revealed that Mitochondrial Ca 2+ Uniporter Regulator 1 (MCUR1) serves as a scaffold factor for uniporter complex assembly. We found that deletion of MCUR1 impaired [Ca 2+ ] m uptake, mitochondrial Ca 2+ current ( I MCU ) and mitochondrial bioenergetics and is associated with increased autophagy. Our new findings indicate that the impairment of [Ca 2+ ] m uptake exacerbated autophagy following ischemia-reperfusion (I/R) injury. In support of our mouse model, human failing hearts show that MCUR1 protein levels are markedly decreased and autophagy markers are increased, demonstrating a crucial link between [Ca 2+ ] m uptake and autophagy during heart failure. Additionally, our results reveal that either oxidation or disruption of human MCU Cys-97 (in mouse Cys-96; gain-of-function MCU C96A mutant) produces a conformational change within the N terminal β-grasp fold of MCU which promotes higher-order MCU complex assembly and increased I MCU activity and mitochondrial ROS levels. The results of our studies using a novel cardiac-specific MCUR1-KO model and a constitutively active global MCU C96A KI mouse model (CRISPR-Cas9 genome edited) elucidate the regulatory role of [Ca 2+ ] m in cardiac bioenergetics and autophagy during oxidative stress and myocardial infarction. Thus, targeting assembly and the activity of MCU complex will offer a new potential therapeutic target in the treatment of cardiomyopathy and heart failure.
Clearance Tests in Clinical Medicine.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Renal Nerve Ablation in Nephritis and Beyond
Authors: Kristina Rodionova, Tilmann Ditting, Roland Veelken
Journal: Journal of the American Society of Nephrology (2021)

Sympathetic nerves innervate the kidney and help regulate glomerular perfusion and filtration, and after renal denervation, altered regulation may affect the course of kidney disease. However, our understanding of denervation's effects on kidney function in humans is incomplete. The autonomous
Conference on Vaccine Research
Journal: JAMA (1999)

EACH YEAR, CDC'S ADVISORY COMMITtee on Immunization Practices (ACIP) reviews the recommended childhood immunization schedule to ensure it remains current with changes in manufacturers' vaccine formulations, revised recommendations for the use of licensed vaccines, and recommendations for newly licensed vaccines.This report presents the recommended childhood immunization schedule for 1999 (Figure 1) and explains the changes that have occurred since January 1998.Since the publication of the recommended childhood immunization schedule in January 1998, 1 the ACIP, the American Academy of Family Physicians (AAFP), and the American Academy of Pediatrics (AAP) have narrowed the recommended options for the use of poliovirus vaccine and have endorsed the use of the newly licensed oral, tetravalent rotavirus vaccine.In addition, recommendations were revised or clarified for the use of hepatitis B vaccine in infants born to hepatitis B surface antigen (HBsAg)-negative mothers, the use of diphtheria and tetanus toxoids and acellular pertussis vaccine (DTaP), and the use of Haemophilus influenzae type b (Hib) conjugate and DTaP combination vaccines for infants aged 2, 4, and 6 months.Detailed recommendations for the use of vaccines are available from the manufacturers' package inserts, ACIP statements on specific vaccines, and the 1997 Red Book. 2 ACIP statements for each recommended childhood vaccine may be viewed, downloaded, and printed at CDC's National Immunization Program World-Wide Web site, http:// www.cdc.gov/nip.
EXACT ENGLISH AND PURE WATER.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P136: Cardiometabolic Burden in Adolescents is Associated with DNA Methylation in Genes Related to Cardiovascular Disease Risk
Authors: Fan He, Arthur Berg, Edward O Bixler, Julio Fernandez-Mendoza, Yuka Imamura Kawasawa, Anna C Salzberg, Eric A Whitsel, Duanping Liao
Journal: Circulation (2017)

Background: Metabolic syndrome is related to increased cardiovascular disease (CVD) risk. Although continuous metabolic syndrome score (cMets) is a marker of cardiometabolic burden in adolescence, the relationship between cardiometabolic burden and DNA methylation has been rarely assessed at this stage of the life course. Hypothesis: Cardiometabolic burden is related to methylation levels in genes related to CVD risk in adolescents. Methods: A sample of 263 independent adolescents from the population-based Penn State Child Cohort follow-up exam (N=421) was used in this analysis. cMets was calculated as the sum of standardized residuals of five established cardiometabolic risk factors, namely waist circumference, mean arterial pressure, homeostatic model assessment of insulin resistance, triglycerides, and high density lipoprotein cholesterol (HDL) concentration. cMets was log-transformed to improve the distribution. Peripheral leukocyte DNA was extracted and subjected to enhanced, reduced representation bisulfite sequencing. The assay provided single nucleotide resolution of DNA methylation in cytosine-phosphate-guanine (CpG) sites and surrounding regions. Bases with &lt; 10x coverage were excluded, resulting a total of 1,609,424 methylation sites. Linear regression was used to model the association between site-specific methylation level and cMets. All models were adjusted for age, race, and sex. A p &lt; 10x10 -8 was used to determine statistical significance. The significant sites were mapped to the hg19 assembly and subjected to Ingenuity Pathway Analysis (IPA) wherein mapped gene sets were examined for enrichment of downstream function and diseases. Permutations were further performed to confirm the robustness of our findings. Results: On average, the sample was 55% male, 79% white, and aged 16.7 (standard deviation = 2.2) years. cMetS was significantly associated with 52 sites within 43 genes. Among the genes, three were related to glucose tolerance, two to endothelial function, and two more to oxidative stress. IPA indicated that genes associated with these functions were significantly enriched for glucose tolerance (p=0.029), endothelial function (p=0.009), and oxidative stress (p=0.028). Indeed, high cMetS was associated with hypermethylation of PRKCD , which is related to diabetes risk, and PRDX5 , which encodes anti-oxidant peroxiredoxin-5. Higher cMetS also was associated with hypomethylation of ID3 . Conclusion: Despite validation is pending, these preliminary findings suggest that cardiometabolic burden in adolescents is related to DNA methylation in genes related to CVD risk factors in adulthood, including glucose tolerance, endothelial function, and oxidative stress.
<i>Psychiatry</i>. A Text-Book for Students and Physicians. By Stewart Paton, M. D., Associate in Psychiatry, Johns Hopkins University; Director of the Labotatory, Sheppard and Enoch Pratt Hospital. Philadelphia &amp; London, J. B. Lippincott Company, 1905
Authors: A. M.
Journal: American Journal of Psychiatry (1905)
The cold edge effect: Mechanisms of edge narrowing following stenting without radiation Hiroyuki Okura, Yoshihiro Morino, Katsuhiro Kitamura, Jorge Luna, Ali H. M. Hassan, Peter J. Fitzgerald, Paul G. Yock, Yasuhiro Honda. Belland General Hospital, Sakai, Japan, Stanford University Medical Center, Stanford, CA
Journal: Journal of the American College of Cardiology (2001)
Oxygen-evolving photosynthetic cyanobacteria for 2D bismuthene radiosensitizer-enhanced cancer radiotherapy
Authors: Rong Chai, Luodan Yu, Caihong Dong, Yipengchen Yin, Sheng Wang, Yu Chen, Qin Zhang
Journal: Bioactive Materials (2022)

The local hypoxic tumor environment substantially hampers the therapeutic efficiency of radiotherapy, which typically requires the large X-ray doses for tumor treatment but induces the serious side effects. Herein, a biomimetic radiosensitized platform based on a natural in-situ oxygen-evolving photosynthetic cyanobacteria combined with two-dimensional (2D) bismuthene with high atomic-number (Z) components, is designed and engineered to effectively modulate the radiotherapy-resistant hypoxic tumor environment and achieve sufficient radiation energy deposition into tumor. Upon the exogenous sequential irradiation of 660 nm laser and X-ray beam, continuous photosynthetic oxygen evolution by the cyanobacteria and considerable generation of reactive oxygen species by the 2D bismuthene radiosensitizer substantially augmented the therapeutic efficacy of radiotherapy and suppressed the in vivo tumor growth, as demonstrated on both LLC-lung tumor xenograft-bearing C57/B6 mice model and 4T1-breast tumor xenograft-bearing Balb/c mice model, further demonstrating the photosynthetic hypoxia-alleviation capability and radiosensitization performance of the engineered biomimetic radiosensitized platform. This work exemplifies a distinct paradigm on the construction of microorganism-enabled tumor-microenvironment modulation and nanoradiosensitizer-augmented radiotherapy for efficient tumor treatment.
Clinical trial design during and beyond the pandemic: the I-SPY COVID trial
Authors: Carolyn S. Calfee, Kathleen D. Liu, Adam L. Asare, Jeremy R. Beitler, Paul A. Berger, Melissa H. Coleman, Alessio Crippa, Andrea Discacciati, Martin Eklund, Daniel C. Files, Sheetal Gandotra, Kevin W. Gibbs, Paul Henderson, Joseph E. Levitt, Ruixiao Lu, Michael A. Matthay, Nuala J. Meyer, Derek W. Russell, Karl W. Thomas, Laura J. Esserman, Aaron M. Mittel, Amy L. Dzierba, Purnema Madahar, Alexis L. Serra, Amanda Rosen, Ivan Garcia, Justin Muir, John Schicchi, Anita Darmanian, Romina Wahab, Katarzyna Gosek, Sara C. Auld, Max W. Adelman, Katherine L. Nugent, Gavin H. Harris, Christina Creel-Bulos, Philip Yang, Joshua F. Detelich, Christine Spainhour, Nathan K. Cobb, Rajiv Sonti, Lindsey A. Orr, Philip A. Robinson, Farjad Sarafian, Esmeralda Martinez, Patrice Jones, Julie Nguyen, Timothy F. Obermiller, Bethany Weiler-Lisowski, Lucia Kufa, Paul L. Saba, Jaime Wyatt, Fady A. Youssef, Maged Tanios, Daniel Blevins, Laura R. Macias, Alexis E. Suarez, Maria B. Reyes, Michelle Jung, Marylee Melendrez, Lissette Rosario-Remigio, Henry Su, Eliot B. Friedman, Christina M. Angelucci, Fredy Chaparro-Rojas, Mitchell P. Sternlieb, Jacqueline B. Sutter, Spencer Whealon, Rahul Nair, Brenda Lopez, Omowunmi Amosu, Hiwet Tzehaie, Richard G. Wunderink, Chirag Patel, Austin Simonson, Jamal Dodin, Tony Oliver, Roxana A. Lupu, Michelle Meyers, Timothy E. Albertson, Angela Haczku, Erin Hardy, Brian M. Morrissey, Maya M. Juarez, Skyler J. Pearson, Richard Anthony Lee, Alpesh N. Amin, Alejandra Jauregui, Scott Fields, Diana Ng, Brian M. Daniel, Kimberly Yee, Chayse Jones, Ellen L. Burnham, Jeffrey D. McKeehan, Caroline A. G. Ittner, John P. Reilly, Nilam S. Mangalmurti, Laura G. Rodrigues, Ariel R. Weisman, Kashif T. Khan, Se Fum Wong, Albert F. Yen, Gregory Peterfreund, Santhi I. Kumar, Peter S. Marshall, Luis E. Huerta, Brett Lindgren, Jerry S. Lee, Anna D. Barker, Julie E. Lang, Mary LaRose, Leigha Landreth, Lisa Parks, Harsh V. Barot, Jonathan L. Koff, John Kazianis, Lindsie L. Boerger
Journal: Nature Medicine (2022)
News Beyond Our Pages
Authors: Marc E. Rothenberg, Jean Bousquet
Journal: Journal of Allergy and Clinical Immunology (2020)

In response to the novel COVID-19 global pandemic, there has been a mass mobilization of the scientific community to find a cure. Gao et al (Science, https://doi.org/10.1126/science.abc1932) have recently developed an inactivated SARS-CoV-2 virus candidate vaccine that induced production of neutralizing antibodies against multiple strains in rodents and non-human primates and protected macaque monkeys against infection without evidence of antibody-dependent immune enhancement. Parallel efforts are ongoing to repurpose existing drugs and develop novel therapeutic agents effective against COVID-19.