tbuckley/cabot-search huggingface dataset:
Abstract PO-089: The impact of Covid-19 on public generosity toward cancer-related crowdfunding efforts
Authors: Katrina A. Fischer, Robert E. Miller, Sidharth Anand, John Glaspy
Journal: Clinical Cancer Research (2020)

Abstract Background: Many patients with cancer rely on public crowdfunding platforms to generate financial support toward costs associated with their medical care. It is unclear how financial uncertainties resulting from the Covid-19 pandemic may impact patient need and public support toward routine cancer-focused campaigns. Methods: Using custom code for web scraping, we identified all campaigns that were generated on the crowdfunding platform GoFundMe.com in the “Medical, Illness and Healing” category between 8/17/2019 and 5/8/2020. This date represents six months of fundraising prior to the first official shelter-in-place order on 3/17/2020. We then abstracted campaigns that included the word “cancer,” originated in the United States, and had raised at least one dollar. Of these cancer-related campaigns, we collected the dollar amount raised in the first 30 days of campaign generation and the total raised to date. Campaigns generated between 2/17/2020 and 3/16/2020 were not included in pre/post-Covid calculations because these campaigns would potentially include contributions made after 3/17/2020 within their first 30-day values. Results: 19,669 cancer campaigns were identified during the study period (16,823 between 8/17/19 and 2/17/20 and 2,846 between 3/17/20 and 5/8/20), raising on average 83% of total funds within the first 30 days of campaign generation. In the six months prior to the first shelter-in-place order (8/17/19-2/17/20), there were on average 91 new cancer campaigns generated daily. Within the first 30 days, these campaigns averaged $4,472 (median $1,815). After 3/17/20, an average of 54 campaigns were generated daily, representing a 40% decline in daily campaign generation. Within the first 30 days, these campaigns averaged $6,130 (median $2,950), representing a 36% and 60% increase from baseline respectively. Conclusion: Public generosity has increased toward cancer fundraising campaigns since the Covid-19 pandemic, but fewer patients are creating new campaigns. Patients can be reassured that they will likely continue to benefit from public support and should not feel limited in asking for help during this period of economic uncertainty. As philanthropy sometimes increases during disaster periods, it is unclear if continued support will persist as longer-term economic changes take effect. Citation Format: Katrina A. Fischer, Robert E. Miller, Sidharth Anand, John Glaspy. The impact of Covid-19 on public generosity toward cancer-related crowdfunding efforts [abstract]. In: Proceedings of the AACR Virtual Meeting: COVID-19 and Cancer; 2020 Jul 20-22. Philadelphia (PA): AACR; Clin Cancer Res 2020;26(18_Suppl):Abstract nr PO-089.
In this issue—2020 draws to a close
Authors: Brad H. Rovin
Journal: Kidney International (2020)

As 2020 draws to a close, our last issue of Kidney International for this year is focused on the consequences of the pandemic for patients receiving renal replacement therapy. We offer our readership 7 original manuscripts, 4 letters to the editor, 1 editorial, 1 review, and 2 commentaries for their consideration. These curated articles were chosen because they report on large populations that the editors felt provided more accurate estimates of incidence, prevalence and consequences of the disease. Early in the pandemic the rush to get information into the public consciousness led many to question the veracity of the data. Without question, coronavirus disease 2019 (COVID-19) has affected every person in every country of the world, either directly, or through its wake of economic, political, and social upheaval. It is fair to say that patients living on dialysis or with a kidney allograft have been particularly devastated by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Mortality of patients on dialysis from Europe and the United States is about 20% to 30%, but for those 75 years of age and older, mortality is higher. Kidney transplant recipients were also hit hard, with mortality in the 20% to 40% range and allograft loss occurring in about 6% of patients. In New York, the mortality of patients who received transplants was about 28% higher than that of matched patients on dialysis. These articles and discussions, though sobering, outline what we as nephrologists should be thinking about and doing for our patients to lessen the impact of SARS-CoV-2, knowing that the pandemic will be around for the foreseeable future. Even as this issue goes to press, we are seeing surges occurring in the United States and Europe. Especially helpful in this regard is the review article on the ethics of kidney care during the pandemic, providing a roadmap for the nephrologist confronting the need for sometimes uncomfortable decision making amid a background of media noise. To be clear, however, the data also show some pleasantly surprising findings, not the least of which is that patients who are on immunosuppression for a kidney allograft can develop antibodies to the virus, an encouraging prospect as vaccine development proceeds at an unprecedented pace. The Editorial Board hopes these articles foster discussion and further development of best practices in the nephrology community. We also realize that while our contributors were faced with immense challenges, contributions to KI were never interrupted and the journal was able to continue to provide cutting edge information on all aspects of nephrology, not just COVID-19. Thank you all for this, and we look forward to 2021 with optimism.
AB0114 Raynaud's phenomenon: correlation between clinical manifestations and nailfold capillary microscopy
Authors: B Rodríguez-Lozano, A Alvarez, J Bethencourt, A Arteaga, M Gantes, E Trujillo, T González
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> <h3>Objectives</h3> To determine the correlations between clinical characteristics and nailfold capillary patterns in patients with Raynaud9s phenomenon (RP). <h3>Methods</h3> Analysis of clinical and immunological features (RP: phases; time duration in years, symmetry, localization; skin and organ involvement, ANA tests) and nailfold capillary patterns were assessed in 150 patients referred for evaluation of RP during the period 1999–2000. Chi-Square and Fisher´s tests were used for statistical analysis. <h3>Results</h3> 142/8 female/male; mean age:42+ 15,6 years; RP duration:5,7 years. 47% of RP were referred without diagnosis, 5,5% as primary RP (pRP) and 49% as secondary RP (sRP): connective tissue diseases (CTD) in 73% of cases. Microangiopathic patterns detected were:38% normal, 25% functional (capillary pallor/hyperemia); 20% CTD pattern without specific capillary abnormalities of scleroderma (SSc), and 17% with SSc-pattern (?slow pattern? 7,6%; ?active pattern? 9,7%). Patients with slow pattern SSc were older than the patients with other patterns: mean average:53,8 years (p &lt; 0,05). RP with uniphasic colour changes were observed principally in patients with normal o functional pattern and RP with biphasic colour changes in patients with SSc-pattern (p &lt; 0,02). Significant association between ?slow? pattern SSc and anticentromere antibodies was detected (p &lt; 0,004) and between ?active? pattern SSc and positive ANA test with nucleolar pattern. Anticentromere antibodies were detected in 9% of patients showing functional pattern with capillary pallor and ?active? pattern SSc was observed in 42% of positive Scl-70 antibodies patients. Sclerodermatous skin changes was associated with SSc-pattern and functional capillary pallor pattern (p &lt; 0,001) and a higher proportion of soft tissue swelling in hands and organ involvement was detected in patients with ?slow? pattern-SSc. <h3>Conclusion</h3> Functional pattern with capillary pallor showed a significant association with uniphasic RP, sclerodermatous skin changes and negative ANA test. Only 42% of patients with positive Scl-70 antibodies exhibited ?active? pattern.
319O The systemic pro-inflammatory response identifies cancer patients with adverse outcomes from SARS-CoV-2 infection
Authors: G. Dettorre, N. Diamantis, A. Loizidou, M. Piccart, J. Chester, A. Jackson, V. Tovazzi, V. Fotia, A. Sita-Lumsden, M. Bower, G. Gaidano, E. Felip, D. Ottaviani, C. Sng, L. Rimassa, A. Santoro, J. Aguilar-Company, E. Seguí, S. Dolly, D. Pinato
Journal: Annals of Oncology (2020)
LBA3 Early detection and localization of multiple cancers using a blood-based methylation assay (ELSA-seq)
Authors: Q. Gao, B. Li, S. Cai, J. Xu, C. Wang, S. Fang, F. Qiu, J. Su, F. Xu, X. Wen, Y. Zhang, G. Wang, H. Liu, Z. Zhang
Journal: Annals of Oncology (2020)
Enzyme-instructed hybrid nanogel/nanofiber oligopeptide hydrogel for localized protein delivery
Authors: Tianyue Jiang, Yudi Ma, Xiao Xu, Qingchun Ji, Mingxing Feng, Cheng Cheng, Yang Feng, Bingfang He, Ran Mo
Journal: Acta Pharmaceutica Sinica B (2020)

Enzyme-catalysis self-assembled oligopeptide hydrogel holds great interest in drug delivery, which has merits of biocompatibility, biodegradability and mild gelation conditions. However, its application for protein delivery is greatly limited by inevitable degradation of enzyme on the encapsulated proteins leading to loss of protein activity. Moreover, for the intracellularly acted proteins, cell membrane as a primary barrier hinders the transmembrane delivery of proteins. The internalized proteins also suffer from acidic and enzymatic degradation in endosomes and lysosomes. We herein develop a protease-manipulated hybrid nanogel/nanofiber hydrogel for localized delivery of intracellularly acted proteins. The embedded polymeric nanogels (CytoC/aNGs) preserve activity of cytochrome c (CytoC) that is an intracellular activator for cell apoptosis as a model protein against proteolysis, and do not affect the gelation properties of the protease-catalysis assembled hydrogels. The injectable hydrogel (CytoC/aNGs/Gel) serves as a reservoir to enhance intratumoral retention and realize sustainable release of CytoC/aNGs. The released CytoC/aNGs increase cellular uptake of CytoC and enhance its intracellular delivery to its target site, cytoplasm, resulting in favorable apoptosis-inducing and cytotoxic effects. We show that a single local administration of CytoC/aNGs/Gel efficiently inhibit the tumor growth in the breast tumor mouse model.
<i>NAIL</i>: an evolutionarily conserved lncRNA essential for licensing coordinated activation of p38 and NFκB in colitis
Authors: Semih Can Akıncılar, Lele Wu, Qin Feng NG, Joelle Yi Heng Chua, Bilal Unal, Taichi Noda, Wei Hong Jeff Chor, Masahito Ikawa, Vinay Tergaonkar
Journal: Gut (2020)

NFκB is the key modulator in inflammatory disorders. However, the key regulators that activate, fine-tune or shut off NFκB activity in inflammatory conditions are poorly understood. In this study, we aim to investigate the roles that NFκB-specific long non-coding RNAs (lncRNAs) play in regulating inflammatory networks.Using the first genetic-screen to identify NFκB-specific lncRNAs, we performed RNA-seq from the p65-/- and Ikkβ-/- mouse embryonic fibroblasts and report the identification of an evolutionary conserved lncRNA designated mNAIL (mice) or hNAIL (human). hNAIL is upregulated in human inflammatory disorders, including UC. We generated mNAILΔNFκB mice, wherein deletion of two NFκB sites in the proximal promoter of mNAIL abolishes its induction, to study its function in colitis.NAIL regulates inflammation via sequestering and inactivating Wip1, a known negative regulator of proinflammatory p38 kinase and NFκB subunit p65. Wip1 inactivation leads to coordinated activation of p38 and covalent modifications of NFκB, essential for its genome-wide occupancy on specific targets. NAIL enables an orchestrated response for p38 and NFκB coactivation that leads to differentiation of precursor cells into immature myeloid cells in bone marrow, recruitment of macrophages to inflamed area and expression of inflammatory genes in colitis.NAIL directly regulates initiation and progression of colitis and its expression is highly correlated with NFκB activity which makes it a perfect candidate to serve as a biomarker and a therapeutic target for IBD and other inflammation-associated diseases.
Long-Term Prognosis of Patients With Coronary Microvascular Disease Using Stress Perfusion Cardiac Magnetic Resonance
Authors: Wenli Zhou, Jonan Chun Yin Lee, Siu Ting Leung, Alta Lai, Tang-Fei Lee, Jeanie Betsy Chiang, Yuet Wong Cheng, Hiu-Lam Chan, Kai-Hang Yiu, Victor King-Man Goh, Dudley John Pennell, Ming-Yen Ng
Journal: JACC. Cardiovascular imaging (2020)

This study investigated the prognosis of coronary microvascular disease (CMD) as determined by stress perfusion cardiac magnetic resonance (CMR) in patients with ischemic symptoms but without significant coronary artery disease (CAD).Patients with CMD have poorer prognosis with various cardiac diseases. The myocardial perfusion reserve index (MPRI) derived from noninvasive stress perfusion CMR has been established to diagnose microvascular angina with a threshold MPRI <1.4. The prognosis of CMD as determined by MPRI is unknown.Chest pain patients without epicardial CAD or myocardial disease from January 2009 to December 2017 were retrospectively included from 3 imaging centers in Hong Kong (HK). Stress perfusion CMR examinations were performed using either adenosine or adenosine triphosphate. Adequate stress was assessed by achieving splenic switch-off sign. Measurement of MPRI was performed in all stress perfusion CMR scans. Patients were followed for major adverse cardiovascular events defined as all-cause death, acute coronary syndrome (ACS), epicardial CAD development, heart failure hospitalization and non-fatal stroke.A total of 218 patients were studied (mean age 59 ± 12 years; 49.5% male) and the average MPRI of that cohort was 1.56 ± 0.33. Females and a history of hyperlipidemia were predictors of lower MPRI. Major adverse cardiovascular events (MACE) occurred in 15.6% of patients during a median follow-up of 5.5 years (interquartile range: 4.6 to 6.8 years). The optimal cutoff value of MPRI in predicting MACE was found with a threshold MPRI ≤1.47. Patients with MPRI ≤1.47 had three-fold increased risk of MACE compared with those with MPRI >1.47 (hazard ratio [HR]: 3.14; 95% confidence interval [CI]: 1.58 to 6.25; p = 0.001). Multivariate Cox regression after adjusting for age and hypertension demonstrated that MPRI was an independent predictor of MACE (HR: 0.10; 95% CI: 0.03 to 0.34; p < 0.001).Stress perfusion CMR-derived MPRI is an independent imaging marker that predicts MACE in patients with ischemic symptom and no overt CAD over the medium term.
The complex relationship between MITF and the immune system: a Melanoma ImmunoTherapy (response) Factor?
Authors: Robert Ballotti, Yann Cheli, Corine Bertolotto
Journal: Molecular Cancer (2020)

The clinical benefit of immune checkpoint inhibitory therapy (ICT) in advanced melanomas is limited by primary and acquired resistance. The molecular determinants of the resistance have been extensively studied, but these discoveries have not yet been translated into therapeutic benefits. As such, a paradigm shift in melanoma treatment, to surmount the therapeutic impasses linked to the resistance, is an important ongoing challenge.This review outlines the multifaceted interplay between microphthalmia-associated transcription factor (MITF), a major determinant of the biology of melanoma cells, and the immune system. In melanomas, MITF functions downstream oncogenic pathways and microenvironment stimuli that restrain the immune responses. We highlight how MITF, by controlling differentiation and genome integrity, may regulate melanoma-specific antigen expression by interfering with the endolysosomal pathway, KARS1, and antigen processing and presentation. MITF also modulates the expression of coinhibitory receptors, i.e., PD-L1 and HVEM, and the production of an inflammatory secretome, which directly affects the infiltration and/or activation of the immune cells.Furthermore, MITF is also a key determinant of melanoma cell plasticity and tumor heterogeneity, which are undoubtedly one of the major hurdles for an effective immunotherapy. Finally, we briefly discuss the role of MITF in kidney cancer, where it also plays a key role, and in immune cells, establishing MITF as a central mediator in the regulation of immune responses in melanoma and other cancers.We propose that a better understanding of MITF and immune system intersections could help in the tailoring of current ICT in melanomas and pave the way for clinical benefits and long-lasting responses.
VLDL Cholesterol Accounts for One-Half of the Risk of Myocardial Infarction Associated With apoB-Containing Lipoproteins
Authors: Mie Balling, Shoaib Afzal, Anette Varbo, Anne Langsted, George Davey Smith, Børge G. Nordestgaard
Journal: Journal of the American College of Cardiology (2020)
15476 Systematic literature review examining satisfaction with abobotulinumtoxinA for esthetic indications
Authors: Joely Kaufman-Janette, Alessio Redaelli, Marina Landau, Elena Gubanova, Riekie Smit, Greg J. Goodman, Yates Chao, Beatriz Molina, Inna Prygova, Alessandra Nogueira
Journal: Journal of the American Academy of Dermatology (2020)
68Ga-DOTANOC PET/CT With Lung Involvement in the Era of COVID-19 Pandemic
Authors: Sarai Morón, Eliana González, Julián Rojas
Journal: Clinical Nuclear Medicine (2020)

Abstract Patient was a 55-year-old man with history of pancreas neuroendocrine tumor grade 2, Ki-67 index 10%. He was treated with surgical resection. 68 Ga-DOTANOC PET/CT was performed as part of follow-up of known disease. The images showed opacities in both lungs’ parenchyma with moderate uptake of radiotracer and mediastinal lymph nodes with high uptake suggestive of infection. Two weeks before a high-resolution CT was performed, these findings in the lungs were not present. The patient was asymptomatic and was referred to the emergency department for reverse transcriptase–polymerase chain reaction COVID-19 test, and the result was positive.
A Proteomic Atlas of Cardiac Amyloid Plaques
Authors: Taxiarchis V. Kourelis, Surendra S. Dasari, Angela Dispenzieri, Joseph J. Maleszewski, Margaret M. Redfield, Ahmed U. Fayyaz, Martha Grogan, Marina Ramirez-Alvarado, Omar F. Abou Ezzeddine, Ellen D. McPhail
Journal: JACC CardioOncology (2020)

In vivo mechanisms of amyloid clearance and cardiac tissue damage in cardiac amyloidosis are not well understood. We aimed to define and quantify the amyloid plaque proteome in cardiac transthyretin amyloidosis (ATTR) and light chain amyloidosis (AL) and identify associations with patient characteristics and outcomes. A proteomics approach was used to identify all proteins in cardiac amyloid plaques, and to compare both normal and diseased controls. All proteins identified within amyloid plaques were defined as the expanded proteome; only proteins that were enriched in comparison to normal and disease controls were defined as the amyloid-specific proteome. Proteomic data from 292 patients with ATTR and 139 patients with AL cardiac amyloidosis were included; 160 and 161 unique proteins were identified in the expanded proteomes, respectively. In the amyloid-specific proteomes, we identified 28 proteins in ATTR, 19 in AL amyloidosis, with 13 proteins overlapping between ATTR and AL. ATTR was characterized by a higher abundance of complement and contractile proteins and AL by a higher abundance of keratins. We found that the proteome of kappa AL had higher levels of clusterin, a protective chaperone, and lower levels of light chains than lambda despite higher levels of circulating light chains. Hierarchical clustering identified a group of patients with worse survival in ATTR, characterized by high levels of PIK3C3, a protein with a central role in autophagy. Cardiac AL and ATTR have both common and distinct pathogenetic mechanisms of tissue damage. Our findings suggest that autophagy represents a pathway that may be impaired in ATTR and should be further studied.
Application of 3D Echocardiography to Everyday Practice: Development of Normal Ranges Is Step 1⁎⁎Editorials published in JACC: Cardiovascular Imaging reflect the views of the authors and do not necessarily represent the views of JACC: Cardiovascular Imaging or the American College of Cardiology.
Authors: Thomas H. Marwick
Journal: JACC. Cardiovascular imaging (2012)
Potential impact of midwives in preventing and reducing maternal and neonatal mortality and stillbirths: a Lives Saved Tool modelling study
Authors: Andrea Nove, Ingrid K Friberg, Luc de Bernis, Fran McConville, Allisyn C Moran, Maria Najjemba, Petra ten Hoope-Bender, Sally Tracy, Caroline S E Homer
Journal: The Lancet Global Health (2020)

Strengthening the capacity of midwives to deliver high-quality maternal and newborn health services has been highlighted as a priority by global health organisations. To support low-income and middle-income countries (LMICs) in their decisions about investments in health, we aimed to estimate the potential impact of midwives on reducing maternal and neonatal deaths and stillbirths under several intervention coverage scenarios.
Outcome of paediatric portopulmonary hypertension in the modern management era: A case report of 6 patients
Authors: Raphael Joye, Frédéric Lador, Yacine Aggoun, Nesrine Farhat, Julie Wacker, Barbara Elisabeth Wildhaber, Jean-Paul Vallée, Anne-Lise Hachulla, Valérie Anne McLin, Maurice Beghetti
Journal: Journal of Hepatology (2020)

Portopulmonary hypertension is a rare but serious complication of portal hypertension or portosystemic shunting. Portopulmonary hypertension is an indication for liver transplantation or shunt closure. However, liver transplantation is contraindicated in patients with severe pulmonary arterial hypertension. Reported mortality rates are high in children with portopulmonary hypertension and there are scarce recommendations on its management. Our aim was to report on our real-world experience of managing portopulmonary hypertension in a specialised centre. We describe a series of 6 children with portopulmonary hypertension. Their median age at diagnosis was 13 years (range 10–15). The underlying liver conditions were cirrhosis of unknown origin (1), congenital portocaval shunts (3), biliary atresia (1), and portal vein cavernoma with surgical mesenterico-caval shunt (1). Median mean pulmonary arterial pressure was 47 mmHg (range 32–70), and median pulmonary vascular resistance was 6.6 Wood units (range 4.3–15.4). All patients except one were treated with a combination of pulmonary arterial hypertension-specific therapy (phosphodiesterase type 5 inhibitors and/or endothelin receptor antagonists and/or prostacyclin analogues). Three patients then benefited from shunt closure and the others underwent liver transplantation. Five patients showed improvement or stabilisation of pulmonary arterial hypertension with no deaths after a mean follow-up of 39 months. Based on our limited experience, early and aggressive treatment with a combination of pulmonary arterial hypertension-specific therapy significantly improves patients' haemodynamic profile and enables the performance of liver transplantation and shunt closure with satisfactory outcomes.
15348 Cutaneous squamous cell carcinoma in nonwhite individuals: A single-institution case-control study
Authors: Sophia A. Ederaine, Collin M. Costello, Connor Maly, Kevin Severson, Shari A. Ochoa, Mark R. Pittelkow, Aleksandar Sekulic, Aaron R. Mangold
Journal: Journal of the American Academy of Dermatology (2020)
32P Clinicopathologic features and prognostic factors in male breast cancer: A single centre experience
Authors: I. Dogan, E. Aydın, N. Ak, K. İbiş, Ö. Şükrüoğlu, S.K. Erciyas, H. Yazıcı, A. Aydıner, P. Saip
Journal: Annals of Oncology (2020)