tbuckley/cabot-search huggingface dataset:
Control of renin secretion in the dog. Effects of furosemide on the vascular and macula densa receptors.
Authors: W ACorsini, J BHook, M DBailie
Journal: Circulation Research (1975)

Experiments were undertaken to investigate further the effect of furosemide on renin secretion in the anesthetized dog. To separate the effects of the macula densa and the baroreceptor mechanisms, experiments were conducted in kidneys made nonfiltering by combining 2.5 hours of renal ischemia with ureteral ligation. Furosemide, in a dose of 5 mg/kg, increased renin secretion and decreased renal resistance in dogs with a nonfiltering kidney. Prior dilation of the nonfiltering kidney with either acetylcholine or papaverine prevented changes in both resistance and renin secretion. However, following dilation of the intact filtering kidney with acetylcholine, furosemide caused an increase in renin secretion. Infusion of d,l-propranolol decreased renin secretion in both the filtering and the nonfiltering kidneys. Following propranolol treatment, furosemide increased renin secretion in the filtering kidney but had no effect on renal resistance. These experiments indicate that furosemide stimulates renin secreti...
Technetium-99m stannous pyrophosphate imaging of experimental infective endocarditis.
Authors: A LRiba, JDowns, M LThakur, AGottschalk, V TAndriole, B LZaret
Journal: Circulation (1978)

Technetium-99m stannous pyrophosphate (99mTc-PYP) cardiac scintigraphy was performed in 15 rabbits with experimental Streptococcus sanguis aortic valve infective endocarditis. The animals were imaged five to seven days after the administration of bacteria, and in each case abnormal accumulation of the tracer was visualized in the region of the aortic valve. Three types of cardiac scintigraphic patterns were demonstrated: focal, multifocal and extensive, each correlating well with the anatomical extent of the lesion as defined by gross pathology. Tissue distribution studies demonstrated a 30 +/- 5.3 (mean +/- SEM) fold excess of radionuclide uptake in the infective endocarditis lesion compared with that of normal myocardium. Imaging of excised hearts from four animals showed an excellent correlation with in vivo imaging as well as gross pathology. Five animals with nonbacterial thrombotic aortic valve endocarditis demonstrated similar scintigraphic and tissue distribution results. In contrast, four normal ...
Imaging by nuclear magnetic resonance in patients with chronic ischemic heart disease.
Authors: C BHiggins, PLanzer, DStark, EBotvinick, N BSchiller, LCrooks, LKaufman, M JLipton
Journal: Circulation (1984)

Cardiac anatomy was defined by gated nuclear magnetic resonance (NMR) imaging at a magnetic field strength of 3.5 kGauss in eight normal subjects and 10 patients with chronic myocardial infarctions. Multisectional imaging was performed with the spin-echo technique and encompassed most of the left ventricle in an imaging time of 5 to 12 min. In all subjects internal cardiac structure was well delineated without the use of any type of contrast medium. The myocardial wall-blood interface was sharply defined, resulting in visualization of trabeculations, papillary muscle, and chordal structures in both ventricles. In patients with ischemic heart disease, the extent of postinfarctional wall thinning, aneurysms, and mural thrombi were depicted on NMR images. Images obtained with the second spin-echo (delay time = 56 msec) demonstrated high signal intensity in regions of the left ventricular chamber adjacent to the site of aneurysms or infarctions; this finding suggested stasis of blood in a region of akinesis o...
Relation between transcardiac and transthoracic current during defibrillation in humans.
Authors: B BLerman, O CDeale
Journal: Circulation Research (1990)

Conceptually, transthoracic defibrillation threshold current can be considered a function of at least two quantities. It is directly proportional to the transcardiac threshold current and inversely proportional to the transcardiac current fraction (FC) or the ratio of transcardiac and transthoracic current. Although experimental and theoretical estimates of FC have been as high as 45%, previous measurements in humans have not been made. This study was designed to quantify FC in humans. During intraoperative testing of the automatic implantable cardioverter defibrillator, transthoracic rescue shocks of 200-400 J were delivered when the device failed to defibrillate. Simultaneous transthoracic voltage (VT) and transcardiac voltage (VC) between two implanted epicardial patch electrodes were measured. The ratio, VC/VT, was 0.04 +/- 0.03 (mean +/- SD) in 10 patients. In 16 dogs, a comparison was made between direct measurement of FC and VC/VT. FC was determined with a specially designed electrode system, which...
Influence of two-stage anatomic correction on size and distensibility of the anatomic pulmonary/functional aortic root in patients with simple transposition of the great arteries.
Authors: H HSievers, P ELange, F WArensman, RRadley-Smith, M HYacoub, DHarms, P HHeintzen, ABernhard
Journal: Circulation (1984)

To evaluate the results of the two-stage anatomic correction of simple transposition of the great arteries the size, distensibility, and histologic characteristics of the anatomic pulmonary root, which arises from the anatomic left ventricle and which we termed the functional aortic root after anatomic correction, were determined in seven patients before and twice after anatomic correction (mean 43 and 671 days) and the results were compared with those in normal control subjects. The diameter of the systolic sinus of the anatomic pulmonary root increased after banding on the average to 140% of normal, whereas the diameter of the diastolic sinus of the functional aortic root increased after anatomic correction on the average to 150% of normal. Diameters of both the systolic and diastolic sinuses of the functional aortic root remained 30% to 55% larger than normal after anatomic correction. Growth potential of the functional aortic root after anatomic correction was normal, whereas its distensibility, as as...
Endoscopy Service – Back On Track Between Covid-19 Surges: A Global Evaluation
Authors: O Elshaarawy, N Le Ngoc Hoa, K Pawlak, N Shanker Behl, P Alavinejad, M Bronswijk, A Voiosu, M Hollenbach, T Cúrdia Gonçalves, G Antonelli, A Piscoya, Q Trung Tran, R Prijic, Z Wong, S Hyub, H Dao Viet, S Salman, K Trong Nguyen, M Cai, M Alboraie
Journal: Endoscopy (2021)

Aims An outbreak of coronavirus disease 19 (COVID-19) has altered the dynamic of endoscopic practices. Many guidelines, questionnaires have been published addressing service resumption during the pandemic. Curious about the situation in different endoscopic units across the globe, the study was designed to evaluate different aspects of practice resumption worldwide and their adherence to guidelines.
Effects of atrial natriuretic factor on the vasoconstrictor actions of the renin-angiotensin system in conscious rats.
Authors: R WLappe, J ATodt, R LWendt
Journal: Circulation Research (1987)

Previous studies have indicated that the hypotensive effects of atrial natriuretic factor were enhanced in renin-dependent hypertensive rats, suggesting that the atrial peptides may antagonize the vasoconstrictor effects of the renin-angiotensin system. The present study was designed to define further the interaction between atrial natriuretic factor and the renin-angiotensin system by examining the hemodynamic effects of Wy-47,663, a synthetic human atrial natriuretic factor, in conscious normotensive rats, in renin-dependent (aortic-ligated) hypertensive rats, and in rats made hypertensive by chronic infusion of angiotensin II. Changes in renal and mesenteric blood flow were continuously monitored in the rats using pulsed Doppler flow probes chronically implanted in the animals one week prior to testing. Infusion of increasing doses of Wy-47,663 caused dose-dependent reductions in mean arterial pressure in all three groups of rats, but the depressor responses were significantly greater in renal hyperten...
Mechanisms of depressed conduction from long-term amiodarone therapy in canine myocardium.
Authors: J HLevine, E NMoore, A HKadish, H FWeisman, C WBalke, R FHanich, J FSpear
Journal: Circulation (1988)

Amiodarone therapy leads to a significant impairment in myocardial conduction, yet it causes only a modest decrease in the maximum rate of depolarization of the action potential (dV/dT). To determine whether the decrease in dV/dT solely accounts for the impaired myocardial conduction or whether passive membrane properties may also be involved, we studied 21 ventricular epicardial tissues from 14 beagles; six dogs received long-term treatment (3-6 weeks) of amiodarone orally, and the remaining dogs served as controls. Amiodarone therapy was associated with a decrease in conduction velocity (0.41 +/- 0.15 vs. 0.56 +/- 0.05 m/sec; p less than 0.01). There was a trend toward a decrease in dV/dT and a significant decrease in the space constant (0.69 +/- 0.27 vs. 1.05 +/- 0.25 mm; p = 0.01), of which the latter correlated closely with the decrease in conduction velocity measured in the amiodarone-treated tissues (r = 0.85, p less than 0.05). These data indicate that the decrease in myocardial conduction velocit...
Multivessel coronary artery spasm.
Authors: R FDunn, D TKelly, NSadick, RUren
Journal: Circulation (1979)

A 60-year-old patient with variant angina was shown to have myocardial ischemia in two different regions supplied by separate major coronary arteries. Neither artery had significant coronary atherosclerotic obstruction. Ventricular fibrillation was noted during ST-segment elevation in anteroseptal leads. The attacks of pain and arrhythmias disappeared during nifedipine therapy.
The effects of human atrial 28-amino acid peptide on systemic and renal hemodynamics in anesthetized rats.
Authors: YHirata, MIshii, TSugimoto, HMatsuoka, KKangawa, HMatsuo
Journal: Circulation Research (1985)

The effects of synthetic human atrial 28-amino acid peptide (alpha-human atrial polypeptide) on systemic and renal hemodynamics were examined in two separate groups of Inactin-anesthetized rats. First, mean arterial pressure, heart rate, and cardiac output were measured before and during infusion of the peptide at rates of 0.04-0.67 microgram/kg per min. Cardiac output was determined by the dye-dilution method with a microcuvette inserted into a carotid-femoral arterial shunt. After 10 minutes of infusion, mean arterial pressure, cardiac output, and total peripheral resistance were reduced in a dose-dependent manner by 21% (P less than 0.001), 9% (P less than 0.05), and 11% (P less than 0.05), respectively, with 0.67 microgram/kg per min of alpha-human atrial natriuretic polypeptide. Despite the marked fall in blood pressure, the heart rate did not change. Second, urine volume, urinary sodium excretion, glomerular filtration rate ([3H]inulin clearance) and renal blood flow ([14C]p-aminohippuric acid sodiu...
Dipyridamole echocardiography test. A new tool for detecting jeopardized myocardium after thrombolytic therapy.
Authors: LBolognese, GSarasso, A SBongo, LRossi, DAralda, CPiccinino, PRossi
Journal: Circulation (1991)

BACKGROUNDWe wished to assess whether dipyridamole echocardiography test (DET) can detect jeopardized myocardium after thrombolytic therapy.METHODS AND RESULTSSeventy-six consecutive patients with a first acute myocardial infarction (AMI) were treated with 2 million IU urokinase i.v. within 4 hours of the onset of AMI and underwent high-dose (as much as 0.84 mg/kg over 10 minutes) DET 8-10 days after AMI. The results were correlated to the anatomy of the infarct-related vessel (IRV). In patients with positive DET, we evaluated the wall motion score index (WMSI; a semiquantitative integrated estimation of extent and severity of the stress-induced dyssynergy). WMSI was derived by summation of individual segment scores divided by the number of interpreted segments. In a 13-segment model, each segment was assigned a score ranging from 1 (normal) to 4 (dyskinetic). Fifty-three patients had positive results on DET. Of these, 42 had dipyridamole-induced new wall motion abnormalities (WMAs) confined to the infarc...
Mean platelet volume in myocardial infarction.
Authors: J van der Lelie, J A Brakenhoff
Journal: BMJ (1983)

decades since Halsted until it was more or less forced on surgeons (and others) who treated the necessity of radical operation as an article of faith.Finally, Professor Dudley's statement: "It was deemed necessary to use a randomised trial" for streptomycin in tuber- culosis is not quite what he terms "a good historical example."If he is referring to the early British trial of streptomycin for meningeal tuberculosis, it is widely understood that that trial was forced on the investigators by a shortage of streptomycin.With these important exceptions Professor Dudley's paper remains a powerful thinkpiece which is, in spirit, an important contribution to any debate about appropriate clinical trials.
Maternal weight change from prepregnancy to 18 months postpartum and subsequent risk of hypertension and cardiovascular disease in Danish women: A cohort study
Authors: Helene Kirkegaard, Mette Bliddal, Henrik Støvring, Kathleen M. Rasmussen, Erica P. Gunderson, Lars Køber, Thorkild I. A. Sørensen, Ellen A. Nøhr
Journal: PLoS Medicine (2021)

Background One-fourth of women experience substantially higher weight years after childbirth. We examined weight change from prepregnancy to 18 months postpartum according to subsequent maternal risk of hypertension and cardiovascular disease (CVD). Methods and findings We conducted a cohort study of 47,966 women with a live-born singleton within the Danish National Birth Cohort (DNBC; 1997–2002). Interviews during pregnancy and 6 and 18 months postpartum provided information on height, gestational weight gain (GWG), postpartum weights, and maternal characteristics. Information on pregnancy complications, incident hypertension, and CVD was obtained from the National Patient Register. Using Cox regression, we estimated adjusted hazard ratios (HRs; 95% confidence interval [CI]) for hypertension and CVD through 16 years of follow-up. During this period, 2,011 women were diagnosed at the hospital with hypertension and 1,321 with CVD. The women were on average 32.3 years old (range 18.0–49.2) at start of follow-up, 73% had a prepregnancy BMI &lt;25, and 27% a prepregnancy BMI ≥25. Compared with a stable weight (±1 BMI unit), weight gains from prepregnancy to 18 months postpartum of &gt;1–2 and &gt;2 BMI units were associated with 25% (10%–42%), P = 0.001 and 31% (14%–52%), P &lt; 0.001 higher risks of hypertension, respectively. These risks were similar whether weight gain presented postpartum weight retention or a new gain from 6 months to 18 months postpartum and whether GWG was below, within, or above the recommendations. For CVD, findings differed according to prepregnancy BMI. In women with normal-/underweight, weight gain &gt;2 BMI units and weight loss &gt;1 BMI unit were associated with 48% (17%–87%), P = 0.001 and 28% (6%–55%), P = 0.01 higher risks of CVD, respectively. Further, weight loss &gt;1 BMI unit combined with a GWG below recommended was associated with a 70% (24%–135%), P = 0.001 higher risk of CVD. No such increased risks were observed among women with overweight/obesity (interaction by prepregnancy BMI, P = 0.01, 0.03, and 0.03, respectively). The limitations of this observational study include potential confounding by prepregnancy metabolic health and self-reported maternal weights, which may lead to some misclassification. Conclusions Postpartum weight retention/new gain in all mothers and postpartum weight loss in mothers with normal-/underweight may be associated with later adverse cardiovascular health.
Rubber Band Ligation of Hemorrhoids: A Single-Center Study of Efficacy and Predictors of Recurrence
Authors: S Laabidi, B Bouchabou, M Ghribi, M Kefi, H Ben Nejma, W Bougassas, R Ennaifer
Journal: Endoscopy (2021)

Aims Rubber band ligation (RBL) is a common therapeutic alternative in the management of hemorrhoidal disease because of its safety, availability and effectiveness. Our study aimed at evaluating the results of RBL of hemorrhoids, and investigating the predictors of disease recurrence after the procedure.
Palliative Treatment of Last Resort and Assisted Suicide
Authors: L Snyder, AL Caplan
Journal: Annals of Internal Medicine (2000)

Letters3 October 2000Palliative Treatment of Last Resort and Assisted SuicideLois Snyder, JD and Arthur L. Caplan, PhDLois Snyder, JDUniversity of Pennsylvania Center for Bioethics; Philadelphia, PA 19104 (Snyder, Caplan)Search for more papers by this author and Arthur L. Caplan, PhDUniversity of Pennsylvania Center for Bioethics; Philadelphia, PA 19104 (Snyder, Caplan)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-7-200010030-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Gates provides an impassioned reaction to the papers on assisted suicide, which we edited for the Finding Common Ground Assisted Suicide Consensus Panel convened by the University of Pennsylvania Center for Bioethics. He calls the issue “an apology for physician-assisted suicide.”The University of Pennsylvania series, in fact, takes no position on the morality of assisted suicide or physician-assisted suicide. The goal of the project was not to argue for or against. Instead, believing that legalization was coming, as it did in Oregon and as it may in other states, we sought to examine how to guide ... Author, Article, and Disclosure InformationAffiliations: University of Pennsylvania Center for Bioethics; Philadelphia, PA 19104 (Snyder, Caplan) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAssisted Suicide: Finding Common Ground Lois Snyder and Arthur L. Caplan Assisted Suicide Compared with Refusal of Treatment: A Valid Distinction? Franklin G. Miller , Joseph J. Fins , Lois Snyder , and The Role of Guidelines in the Practice of Physician-Assisted Suicide Arthur L. Caplan , Lois Snyder , Kathy Faber-Langendoen , and Should Assisted Suicide Be Only Physician Assisted? Kathy Faber-Langendoen , Jason H.T. Karlawish , and Responding to Legal Requests for Physician-Assisted Suicide James A. Tulsky , Ralph Ciampa , Elliott J. Rosen , and Palliative Treatment of Last Resort and Assisted Suicide Lawrence K. Gates Jr. Metrics 3 October 2000Volume 133, Issue 7Page: 564KeywordsBioethicsFoodPalliative careSedationSuicide ePublished: 3 October 2000 Issue Published: 3 October 2000 CopyrightCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Excimer laser-facilitated coronary angioplasty. Relative risk analysis of acute and follow-up results in 200 patients.
Authors: J ABittl, T ASanborn
Journal: Circulation (1992)

BACKGROUNDExcimer laser coronary angioplasty has been reported to be a promising treatment for complex coronary artery disease. The purpose of this study was to define the predictors of acute success and restenosis after this experimental intervention.METHODS AND RESULTSA cohort of 200 consecutive patients had a minimum of 6 months of follow-up evaluation after treatment of 215 coronary stenoses that were carefully selected for excimer laser coronary angioplasty. At the time of the initial procedure, the laser catheter alone produced a residual stenosis of less than or equal to 50% at 119 of 215 lesions (55.4%). For complete dilatation, 87.9% of the lesions required adjunctive balloon angioplasty. Clinical success was achieved in 183 of the 200 patients (91.5%), as indicated by a reduction by at least 20% of the narrowing of the vessel diameter, less than or equal to 50% residual stenosis, and no in-hospital complication. Complications included abrupt closure (5.0%), myocardial infarction (3.5%), bypass s...
Polymeric drug delivery systems by additive manufacturing
Authors: Sedigheh Borandeh, Bas van Bochove, Arun Teotia, Jukka Seppälä
Journal: Advanced Drug Delivery Reviews (2021)

Additive manufacturing (AM) is gaining interests in drug delivery applications, offering innovative opportunities for the design and development of systems with complex geometry and programmed controlled release profile. In addition, polymer-based drug delivery systems can improve drug safety, efficacy, patient compliance, and are the key materials in AM. Therefore, combining AM and polymers can be beneficial to overcome the existing limitations in the development of controlled release drug delivery systems. Considering these advantages, here we are focusing on the recent developments in the field of polymeric drug delivery systems prepared by AM. This review provides a comprehensive overview on a holistic polymer–AM perspective for drug delivery systems with discussion on the materials, properties, design and fabrication techniques and the mechanisms used to achieve a controlled release system. The current challenges and future perspectives for personalized medicine and clinical use of these systems are also briefly discussed.
The potential impact of nuclear magnetic resonance imaging on cardiovascular diagnosis.
Authors: LKaufman, LCrooks, PSheldon, HHricak, RHerfkens, WBank
Journal: Circulation (1983)

Nuclear magnetic resonance (NMR) is used to generate cross-sectional images of the human body that show excellent anatomic and functional definition. The NMR imaging process involves interactions between electromagnetic fields and the hydrogen nuclei being imaged. These interactions occur on time scales of milliseconds to seconds. Consequently, the motion of these nuclei, for instance, when carried by blood, produces distinct signatures that are used to assess flow in major vessels. Myocardial dyskinesis also produces visible effects. Because of these effects, NMR imaging may be a safe and effective tool in the diagnosis and assessment of cardiovascular disease.
Racial (black-white) comparisons of the relationship of levels of endogenous sex hormones to serum lipoproteins during male adolescence: the Bogalusa Heart Study.
Authors: S RSrinivasan, D SFreedman, G SSundaram, L SWebber, G SBerenson
Journal: Circulation (1986)

The cross-sectional relationship of endogenous androgens (testosterone, androstenedione, and dehydroepiandrosterone sulfate [DHEA-S]), estrogen (estradiol) and progestin (progesterone) to serum levels of lipoprotein cholesterol (very low-density [VLDL], low-density [LDL], and high-density lipoprotein [HDL]) and apolipoproteins (apo A-I and apo B) were studied in white (n = 251) and black (n = 258) adolescent boys, ages 11 to 17 years, as part of the Bogalusa Heart Study. Black boys had significantly higher levels of estradiol, HDL cholesterol, and apo A-I, and lower levels of androstenedione and VLDL cholesterol than white boys, independent of age and adiposity. Age was correlated strongly with testosterone and androstenedione, and moderately with DHEA-S and estradiol levels in both races. However, only in white boys was age consistently related to VLDL cholesterol (positively), HDL cholesterol (negatively), and apo A-I (negatively). Overall, testosterone was associated inversely with HDL cholesterol and ...
Argonaute-CLIP delineates versatile, functional RNAi networks in Aedes aegypti, a major vector of human viruses
Authors: Kathryn Rozen-Gagnon, Meigang Gu, Joseph M. Luna, Ji-Dung Luo, Soon Yi, Sasha Novack, Eliana Jacobson, Wei Wang, Matthew R. Paul, Troels K.H. Scheel, Thomas Carroll, Charles M. Rice
Journal: Cell Host & Microbe (2021)