tbuckley/cabot-search huggingface dataset:
Abstract P358: Sleepiness and Subclinical Measures of Atherosclerosis in a Bi-racial Cohort: The Bogalusa Heart Study
Authors: Patrick Stuchlik, Benjamin Pollock, Wei Chen, Emily Harville, Suzanne Bertisch, Susan Redline, Lydia Bazzano
Journal: Circulation (2017)

Introduction: That adverse health outcomes, including atherosclerosis, are associated with sleep disturbance is well-documented; however, evidence from diverse populations on the magnitude of this association, or investigating sleepiness as an outcome, is scarce. Methods: We examined data from theBogalusa Heart Study, a long-term community-based observational study of a biracial cohort, with first measurements in childhood in 1973. Men and women (n=546) who underwent a measure of carotid intima-media thickness (IMT), calculated as the composite IMT (cIMT), mean of six segments (common and internal carotid, and carotid bifurcation, each left and right), and completed the Epworth Sleepiness Scale (ESS), were included. Multivariable logistic regression was employed to model the association between ordinal self-rated sleepiness and cIMT per standard deviation, adjusted for age, sex, smoking status (at time of IMT measurement), hours of sleep, symptoms of sleep disturbance, and previous heart attack. Based on previous race-specific findings, data were analyzed separately by race. Results: Of whites (n=356), 59.6% were female and 22.5% were current smokers. Mean (SD) age was 43.1 (4.4) years, and cIMT was 0.6 (0.1) mm. Of African-Americans (n=190), 66.8% were female, 34.7% were current smokers. Mean (SD) age was 42.8 (4.6) years, and cIMT was 0.7 (0.2) mm. Multivariate modeling found a significant race-cIMT interaction term (p=0.04). In stratified analyses, the adjusted odds of abnormal sleepiness (vs. normal sleepiness) were 1.40 times greater (95% CI: 1.04-1.90) per 1-SD increase in cIMT in whites, while among black participants, the odds ratio (95% CI) was 1.01 (0.68-1.50). Conclusions: There was a significant association between unfavorable subclinical measures of atherosclerosis and excessive daytime sleepiness among white participants.
Importance of the locus coeruleus-norepinephrine system in sleep-wake regulation: Implications for aging and Alzheimer's disease
Authors: Maxime Van Egroo, Ekaterina Koshmanova, Gilles Vandewalle, Heidi I.L. Jacobs
Journal: Sleep Medicine Reviews (2022)

Five decades ago, seminal studies positioned the brainstem locus coeruleus (LC) norepinephrine (NE) system as a key substrate for the regulation of wakefulness and sleep, and this picture has recently been elaborated thanks to methodological advances in the precise investigation and experimental modulation of LC structure and functions. This review presents and discusses findings that support the major role of the LC-NE system at different levels of sleep-wake organization, ranging from its involvement in the overall architecture of the sleep-wake cycle to its associations with sleep microstructure, while accounting for the intricate neuroanatomy surrounding the LC. Given the particular position held by the LC-NE system by being at the intersection of sleep-wake dysregulation and initial pathophysiological processes of Alzheimer's disease (AD), we conclude by examining emerging opportunities to investigate LC-NE mediated relationships between sleep-wake alteration and AD in human aging. We further propose several research perspectives that could support the LC-NE system as a promising target for the identification of at-risk individuals in the preclinical stages of AD, and for the development of novel preventive interventions.
<i>QuickStats:</i> Management of Patient Health Information Functions* Among Office-Based Physicians With and Without a Certified Electronic Health Record (EHR) System† — National Electronic Health Records Survey, United States, 2018
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

With 95% confidence intervals indicated with error bars.† In 2018, 78.7% of office-based physicians had a certified electronic health record (EHR) system, defined by physicians answering "yes" to having a current system that "meets meaningful use criteria defined by the U.S. Department of Health and Human Services." https://www.cms.gov/Regulations-and-Guidance/Legislation/EHRIncentivePrograms/Certification.In 2018, 78.7% of office-based physicians had a certified electronic health record (EHR) system.A higher percentage of officebased physicians with a certified EHR system compared with those without a system electronically sent (95.5% versus 72.8%), received (95.3% versus 69.0%), integrated (92.8% versus 67.4%), or searched for (90.5% versus 73.3%) patient health information.
Colorectal cancer caregivers demonstrate need for a one-stop comprehensive resource.
Authors: Kim Newcomer, Negeen Fathi, Manju George, Abdullah Shoeb, Andrea Goodman
Journal: Journal of Clinical Oncology (2022)

74 Background: Patients with colorectal cancer often require a caregiver’s assistance with daily activities, medical care, social needs, and navigating treatment options. In providing this assistance, caregivers may be at an increased risk for psychological distress. Direct support to manage a caregiver’s stress and maintain their well-being is essential. More research is needed to fully understand the challenges caregivers face and to provide solutions. Previous studies have found that caregivers experience high levels of depression and anxiety, and many lack access to resources despite the evidenced need for support. Methods: A survey was disseminated via the Colorectal Cancer Alliance’s Blue Hope Nation community for two weeks and by email. Forty caregivers of colorectal cancer patients of varying stages and diverse demographic backgrounds completed the survey. Results: Half of the respondents have been providing care for 1-3 years, and 63% indicated they were a patient’s spouse or partner. Most caregivers were in the 35-40 age group, and 30% were full-time caregivers. A majority reported experiencing anxiety/stress (97.5%), fatigue (80%), poor sleep (77.5%), depression (75%), and feelings of isolation (72.5%). Primary caregiver activities included providing moral support, completing household chores, and researching treatment options. Only 32.5% of caregivers received help or advice from their patient’s doctors or medical team on the tasks listed. The survey results suggest the need for a comprehensive resource with information on medications, side effects and treatments; a guide for medical discussions; organization for medical forms and documents; and a tool to connect with peer caregivers. Conclusions: Survey themes indicate that caregivers often feel unprepared to provide care, have inadequate knowledge, and receive little guidance from health care providers, so there is continued need to place both the patient and caregiver at the center of care. A comprehensive centralized resource given at diagnosis with vital information and a method for document organization would help reduce caregivers’ stress and allow them to share information easily. Such patient and caregiver-directed resources would enable a better quality of care experience, and potentially better mental health outcomes, for patients and their caregivers.
Results of a randomized trial comparing a high fat low carbohydrate diet to the NCEP step 2 diet: Effect on LDL cholesterol subclasses Y. Wady Aude, Gervasio A. Lamas, Francisco Lopez-Jimenez, Marie Almon, Melinda Hansen, Eric H. Lieberman, Gerardo Rojas, Robert Superko, Arthur Agatston. Mount Sinai Medical Center, Miami Beach, FL
Journal: Journal of the American College of Cardiology (2001)
Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)
Authors: Warren Fiskus, Steffen Boettcher, Naval Daver, Christopher P. Mill, Koji Sasaki, Christine E. Birdwell, John A. Davis, Koichi Takahashi, Tapan M. Kadia, Courtney D. DiNardo, Qi Jin, Yuan Qi, Xiaoping Su, Gerard M. McGeehan, Joseph D. Khoury, Benjamin L. Ebert, Kapil N. Bhalla
Journal: Blood Cancer Journal (2022)

Abstract Treatment with Menin inhibitor (MI) disrupts the interaction between Menin and MLL1 or MLL1-fusion protein (FP), inhibits HOXA9/MEIS1, induces differentiation and loss of survival of AML harboring MLL1 re-arrangement (r) and FP, or expressing mutant (mt)-NPM1. Following MI treatment, although clinical responses are common, the majority of patients with AML with MLL1-r or mt-NPM1 succumb to their disease. Pre-clinical studies presented here demonstrate that genetic knockout or degradation of Menin or treatment with the MI SNDX-50469 reduces MLL1/MLL1-FP targets, associated with MI-induced differentiation and loss of viability. MI treatment also attenuates BCL2 and CDK6 levels. Co-treatment with SNDX-50469 and BCL2 inhibitor (venetoclax), or CDK6 inhibitor (abemaciclib) induces synergistic lethality in cell lines and patient-derived AML cells harboring MLL1-r or mtNPM1. Combined therapy with SNDX-5613 and venetoclax exerts superior in vivo efficacy in a cell line or PD AML cell xenografts harboring MLL1-r or mt-NPM1. Synergy with the MI-based combinations is preserved against MLL1-r AML cells expressing FLT3 mutation, also CRISPR-edited to introduce mtTP53. These findings highlight the promise of clinically testing these MI-based combinations against AML harboring MLL1-r or mtNPM1.
DNA Methylation-Based Subtype Prediction for Pediatric Acute Lymphoblastic Leukemia (ALL)
Authors: Jessica Nordlund, Christofer Bäcklin, Vasilios Zachariadis, Lucia Cavelier, Johan Dahlberg, Ingegerd Öfverholm, Gisela Barbany, Ann Nordgren, Elin Övernäs, Jonas Abrahamsson, Trond Flaegstad, Mats Heyman, Ólafur G Jónsson, Jukka A. Kanerva, Rolf Larsson, Josefine Palle, Kjeld Schmiegelow, Mats G Gustafsson, Gudmar Lönnerholm, Erik Forestier, Ann-Christine Syvänen
Journal: Blood (2014)
Eleventh Annual Meeting of the International Society for Oncodevelopmental Biology and Medicine
Journal: JNCI Journal of the National Cancer Institute (1982)

Eleventh Annual Meeting of the International Society for Oncodevelopmental Biology and Medicine JNCI: Journal of the National Cancer Institute, Volume 69, Issue 6, December 1982, Page 1421, https://doi.org/10.1093/jnci/69.6.1421-d Published: 01 December 1982
Clinical results of dynamic tumor-tracking stereotactic body radiotherapy with real-time monitoring for liver tumors using a gimbal-mounted linac: A multi-institutional phase II study.
Authors: Yusuke Iizuka, Masahiro Hiraoka, Masaki Kokubo, Takashi Sakamoto, Katsuyuki Karasawa, Keiko Murofushi, Mitsuhiro Nakamura, Yukinori Matsuo, Satoshi Morita, Haruo Inokuchi, Takashi Mizowaki
Journal: Journal of Clinical Oncology (2022)

441 Background: Dynamic tumor-tracking (DTT) stereotactic body radiotherapy (SBRT) with real-time monitoring for liver tumors using a gimbal-mounted linac can decrease the normal liver dose and planning target volume (PTV) without sacrificing the target dose. We hypothesized that this method would yield excellent tumor control comparable to that by the conventional SBRT. We conducted a multi-institutional prospective phase II study to evaluate the safety and efficacy of DTT-SBRT for liver tumors (UMIN-CTR, UMIN000017886). Methods: The main eligibility criteria were as follows: (1) &lt; 4 liver tumors; (2) technical difficulties with percutaneous ablation therapies, inoperable lesions, or patient refusal to undergo surgery; (3) Eastern Cooperative Oncology Group performance status of 0–2; (4) Child-Pugh score of ≤8; and (5) respiratory motion of ≥10 mm. The primary endpoint was the local control rate (LC) at 2 years (expected endpoint: &gt; 90%), and the secondary endpoints were overall survival rate (OS), progression-free survival rate (PFS), and treatment-related toxicity. We performed DTT-SBRT with 40 Gy in 5 fractions prescribed to the PTV D95, and a maximum dose of 55−58 Gy using 7–9 static non-coplanar ports of the 6-MV beam was applied. The Kaplan-Meier analysis was performed to estimate the OS and LC. Treatment-related toxicity was scored according to the Common Terminology Criteria for Adverse Events v.4.0. Results: Forty-eight patients (48 tumors) were registered from four institutes and successfully treated between September 2015 and March 2019. Their median age was 74 years (range, 52–97). Thirty-nine tumors were hepatocellular carcinomas, and nine were metastatic liver tumors. The median tumor size was 5.8 ml (range, 0.7–64.1). At the time of data cutoff on March 31, 2021, the median follow-up period was 36.5 months (range, 3.0–62.4). The 2-year LC was 98.0%. Two-year OS and PFS were 88.8% and 55.1%, respectively. Recurrences were observed in 33 patients (68.5%). One patient (0.2%) had local recurrence, 30 (62.5%) developed new hepatic lesions outside of the irradiation field, and 9 (18.8%) had distant metastases. Grade 3 adverse events were observed in seven patients, including elevation of liver or biliary enzyme levels and hematopoietic adverse events. No treatment-related toxicity of grade 4 or higher was observed. Conclusions: Employing DTT-SBRT to treat liver tumors resulted in excellent LC with acceptable incidence of adverse events. This method will be a promising alternative therapy for patients who cannot receive surgery or percutaneous ablation therapy. To the best of our knowledge, this is the first phase II trial evaluating DTT-SBRT for liver tumors. Clinical trial information: UMIN000017886.
In This Issue
Journal: American Journal of Psychiatry (2004)

Making Math ExcitingHint: money doesn't hurt.The stimulant methylphenidate increased brain levels of dopamine, a neurotransmitter involved in motivation, in healthy people performing a mathematical task rewarded by money.Volkow et al. (p.1173) found, however, that dopamine did not increase when the participants viewed scenic pictures or when they worked the math problems without methylphenidate, even though dopamine is sensitive to environmental stimulation.This interaction of methylphenidate and the math task suggests that methylphenidate amplifies the intrinsic cognitive salience of the activity.The subjects were more likely to describe the task as "interesting" or "exciting" after methylphenidate administration than after placebo, and these ratings correlated with the dopamine changes.Methylphenidate may increase attention by enhancing the saliency of the task and thus increasing the interest it elicits.Nonpharmacological ways of increasing salience-for instance, making schoolwork more interesting-might be worth a try.
Delayed age of menarche of athletes
Authors: R. M. Malina
Journal: JAMA (1982)

<h3>To the Editor.—</h3> It is my fear that the conclusion of Frisch and colleagues (1981;246:1559), based on data that are derived from a small and seemingly unusual sample, may cause undue concern and worry by children, parents, and coaches. Indeed, the conclusion that training before menarche will delay menarche has been widely disseminated. There are thousands of premenarcheal girls engaged in sports training, and this questionable conclusion can have a negative impact on sports for girls. The conclusion is based on a small sample, 12 swimmers and six runners, who began training before menarche. Correlation analysis indicated a relationship between training before menarche and the age at menarche. It indicates only a relationship between the two variables, but does not indicate a cause-effect relationship. It could well have been that the young women took up training because of their delayed maturation rather than the training causing late maturation. If one
Serial, non-invasive, high resolution magnetic resonance microscopy measures progression of atherosclerosis in apolipoprotein E deficient mice Robin P. Choudhury, Gilberto Aguinaldo, James X. Rong, John T. Fallon, Valentin Fuster, Edward A. Fisher, Zahl A. Fayad. Mount Sinai School of Medicine, New York, NY
Journal: Journal of the American College of Cardiology (2001)
The PROCESS 2020 Guideline: Updating Consensus Preferred Reporting Of CasE Series in Surgery (PROCESS) Guidelines
Authors: Riaz A. Agha, Catrin Sohrabi, Ginimol Mathew, Thomas Franchi, Ahmed Kerwan, Niamh O’Neill, Achilles Thoma, Andrew J. Beamish, Ashraf Noureldin, Ashwini Rao, Baskaran Vasudevan, Ben Challacombe, Benjamin Perakath, Boris Kirshtein, Burcin Ekser, C.S. Pramesh, Daniel M. Laskin, David Machado-Aranda, Duilio Pagano, Gaurav Roy, Huseyin Kadioglu, Iain J. Nixon, Indraneil Mukhejree, James A. McCaul, James Chi-Yong Ngu, Joerg Albrecht, Juan Gomez Rivas, Kandiah Raveendran, Laura Derbyshire, M Hammad Ather, Mangesh A. Thorat, Michele Valmasoni, Mohammad Bashashati, Mushtaq Chalkoo, Nan Zun Teo, Nicholas Raison, Oliver J. Muensterer, Patrick James Bradley, Prabudh Goel, Prathamesh S. Pai, Raafat Yahia Afifi, Richard David Rosin, Roberto Coppola, Roberto Klappenbach, Rolf Wynn, Salim Surani, Salvatore Giordano, Samuele Massarut, Shahzad G. Raja, Somprakas Basu, Syed Ather Enam, Todd Galvin Manning, Trent Cross, Veena KL. Karanth, Zubing Mei
Journal: International Journal of Surgery (2020)
GW29-e1133 Influence of Load Physical Trainings on Tolerance Indicators to The Exercise Stress and The Clinical Condition of Patients With Chronic Heart Failure
Authors: Umida Kamilova, Dilnoza Tagaeva, Zulfya Rasulova, Rano Khakimova, Bekzod Toshev
Journal: Journal of the American College of Cardiology (2018)
Table of Contents
Authors: Gerhard Giebisch, Peter Aronson, Camillo Carrara, Laura Cappelletti, Valentina Portalupi, Alan Kliger, Mario Cozzolino, Vivekanand Jha, Glenda Harbert, T Alp Ikizler, Federico Alberici, Elisa Delbarba, Chiara Manenti, Laura Econimo, Francesca Valerio, Alessandra Pola, Camilla Maffei, Stefano Possenti, Bernardo Lucca, Roberta Cortinovis, Vincenzo Terlizzi, Mattia Zappa, Chiara Saccà, Elena Pezzini, Eleonora Calcaterra, Paola Piarulli, Alice Guerini, Francesca Boni, Agnese Gallico, Alberto Mucchetti, Stefania Affatato, Sergio Bove, Martina Bracchi, Ester Maria Costantino, Roberto Zubani, Corrado Camerini, Paola Gaggia, Ezio Movilli, Nicola Bossini, Mario Gaggiotti, Francesco Scolari, Marian Goicoechea, Luis Alberto, Sánchez Cámara, Nicolás Macías, Alejandra Muñoz De Morales, Ángela Rojas, Arturo Bascuñana, David Arroyo, Almudena Vega, Soraya Abad, Eduardo Verde, Ana María, García Prieto, Úrsula Verdalles, Diego Barbieri, Felipe Andrés, Javier Delgado, Antonia Carbayo, Adriana Mijaylova, Rosa Acosta, Alberto Melero, Patrocinio Tejedor, Ana Rodriguez Benitez, María Pérez De José, Rodriguez Luisa, Fernando Ferrero, Manuel Anaya, Daniel Rengel, José Barraca, Inés Luño
Journal: Kidney International (2020)
Council on Drugs
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Angioscintigraphic assessment of cardiac resynchronization by biventricular pacing in heart failure patients Christophe Leclercq, Sr., Gilles Rouault, Sr., Christine Alonso, Sr., Anne Devillers, Claude Daubert, Sr., Department de Cardiologie et Maladies Vasculaires CHU, Rennes, France
Journal: Journal of the American College of Cardiology (2001)
Abstract P098: An Epigenome-wide Study of Obesity in African American Youth and Young Adults: Novel Findings, Replication in Neutrophils and Relationship With Gene Expression
Authors: Xiaoling Wang, Yue Pan, Haidong Zhu, Guang Hao, Xin Wang, Yisong Huang, Gregory Harshfield, Vernon Barnes, Huidong Shi, Shaoyong Su
Journal: Circulation (2017)

Background: Several large-scale epigenome wide association studies on obesity-related DNA methylation changes have been published and in total identified 46 CpG sites. These studies were conducted in middle-aged and older adults of Caucasians and African Americans (AAs) using leukocytes. To what extend these signals are independent of cell compositions as well as to what extend they may influence gene expression have not been systematically investigated. Furthermore, the high prevalence of obesity comorbidities in middle-aged or older population may hide or bias obesity itself related DNA methylation changes. Methods: In this study of healthy AA youth and young adults, genome wide DNA methylation data from leukocytes were obtained from three independent studies: EpiGO study (96 obese cases vs. 92 lean controls, aged 14-21, 50% females, test of interest is obesity status), LACHY study (284 participants from general population, aged 14-18, 50% females, test of interest is BMI), and Georgia Stress and Heart study (298 participants from general population, aged 18-38, 52% females, test of interest is BMI) using the Infinium HumanMethylation450 BeadChip. Genome wide DNA methylation data from purified neutrophils as well as genome wide gene expression data from leukocytes using Illumina HT12 V4 array were also obtained for the EpiGO samples. Results: The meta-analysis on the 3 cohorts identified 76 obesity related CpG sites in leukocytes with p&lt;1х10 -7 . Out of the 46 previously identified CpG sites, 36 can be replicated in this AA youth and young adult sample with same direction and p&lt;0.05. Out of the 107 CpG sites including the 36 replicated ones and the 71 newly identified ones, 71 CpG sites (66%) had their relationship with obesity replicated in purified neutrophils (p&lt;0.05). The analysis on the cis regulation of the 107 CpG sites on gene expression showed that 59 CpG sites had at least one gene within 250kb having expression difference between obese cases and lean controls. Furthermore, out of the 59 CpG sites, 6 showed significantly negative correlations and 1 showed significantly positive correlation with the differentially expressed genes. These CpG sites located in SOCS3, CISH, ABCG1, PIM3 and PTGDS genes. Conclusion: In this study of AA youth and young adults, we identified novel CpG sites associated with obesity and replicated majority of the CpG sites previously identified in middle-aged and older adults. For the first time, we showed that majority of the obesity related CpG sites identified from leukocytes are not driven by cell compositions and provided the direct link between DNA methylation-gene expression-obesity status for 7 CpG sites in 5 genes.
Numerosities are not ersatz numbers
Authors: Catarina Dutilh Novaes, César Frederico Dos Santos
Journal: Behavioral and Brain Sciences (2021)

Abstract In describing numerosity as “a kind of ersatz number,” Clarke and Beck fail to consider a familiar and compelling definition of numerosity, which conceptualizes numerosity as the cognitive counterpart of the mathematical concept of cardinality; numerosity is the magnitude, whereas number is a scale through which numerosity/cardinality is measured. We argue that these distinctions should be considered.